id	sid	tid	token	lemma	pos
admet-1476	1	1	food	food	NOUN
admet-1476	1	2	effect	effect	NOUN
admet-1476	1	3	risk	risk	NOUN
admet-1476	1	4	assessment	assessment	NOUN
admet-1476	1	5	in	in	ADP
admet-1476	1	6	preformulation	preformulation	NOUN
admet-1476	1	7	stage	stage	NOUN
admet-1476	1	8	using	use	VERB
admet-1476	1	9	material	material	NOUN
admet-1476	1	10	sparing	sparing	NOUN
admet-1476	1	11	µflux	µflux	NOUN
admet-1476	1	12	methodology	methodology	NOUN
admet-1476	1	13	doi	doi	NOUN
admet-1476	1	14	:	:	PUNCT
admet-1476	1	15	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	NOUN
admet-1476	1	16	299	299	NUM
admet-1476	1	17	admet	admet	X
admet-1476	1	18	&	&	CCONJ
admet-1476	1	19	dmpk	dmpk	PROPN
admet-1476	1	20	10(4	10(4	NUM
admet-1476	1	21	)	)	PUNCT
admet-1476	1	22	(	(	PUNCT
admet-1476	1	23	2022	2022	NUM
admet-1476	1	24	)	)	PUNCT
admet-1476	1	25	299	299	NUM
admet-1476	1	26	-	-	SYM
admet-1476	1	27	314	314	NUM
admet-1476	1	28	;	;	PUNCT
admet-1476	1	29	doi	doi	NOUN
admet-1476	1	30	:	:	PUNCT
admet-1476	1	31	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	ADJ
admet-1476	1	32	open	open	ADJ
admet-1476	1	33	access	access	NOUN
admet-1476	1	34	:	:	PUNCT
admet-1476	1	35	issn	issn	PROPN
admet-1476	1	36	:	:	PUNCT
admet-1476	1	37	1848	1848	NUM
admet-1476	1	38	-	-	SYM
admet-1476	1	39	7718	7718	NUM
admet-1476	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1476	1	41	original	original	ADJ
admet-1476	1	42	scientific	scientific	ADJ
admet-1476	1	43	paper	paper	NOUN
admet-1476	1	44	food	food	NOUN
admet-1476	1	45	effect	effect	NOUN
admet-1476	1	46	risk	risk	NOUN
admet-1476	1	47	assessment	assessment	NOUN
admet-1476	1	48	in	in	ADP
admet-1476	1	49	preformulation	preformulation	NOUN
admet-1476	1	50	stage	stage	NOUN
admet-1476	1	51	using	use	VERB
admet-1476	1	52	material	material	NOUN
admet-1476	1	53	sparing	sparing	NOUN
admet-1476	1	54	µflux	µflux	NOUN
admet-1476	1	55	methodology1	methodology1	PROPN
admet-1476	1	56	corinne	corinne	PROPN
admet-1476	1	57	jankovskya	jankovskya	PROPN
admet-1476	1	58	*	*	PROPN
admet-1476	1	59	,	,	PUNCT
admet-1476	1	60	oksana	oksana	PROPN
admet-1476	1	61	tsinmanb	tsinmanb	PROPN
admet-1476	1	62	,	,	PUNCT
admet-1476	1	63	naveen	naveen	PROPN
admet-1476	1	64	k.	k.	PROPN
admet-1476	1	65	thakrala	thakrala	PROPN
admet-1476	1	66	,	,	PUNCT
admet-1476	1	67	*	*	NOUN
admet-1476	1	68	,	,	PUNCT
admet-1476	1	69	#	#	NOUN
admet-1476	1	70	aboehringer	aboehringer	NOUN
admet-1476	1	71	ingelheim	ingelheim	PROPN
admet-1476	1	72	pharmaceuticals	pharmaceuticals	PROPN
admet-1476	1	73	,	,	PUNCT
admet-1476	1	74	inc	inc	PROPN
admet-1476	1	75	.	.	PROPN
admet-1476	1	76	,	,	PUNCT
admet-1476	1	77	900	900	NUM
admet-1476	1	78	ridgebury	ridgebury	NOUN
admet-1476	1	79	road	road	NOUN
admet-1476	1	80	,	,	PUNCT
admet-1476	1	81	ridgefield	ridgefield	PROPN
admet-1476	1	82	,	,	PUNCT
admet-1476	1	83	connecticut	connecticut	PROPN
admet-1476	1	84	06877	06877	NUM
admet-1476	1	85	,	,	PUNCT
admet-1476	1	86	united	united	PROPN
admet-1476	1	87	states	states	PROPN
admet-1476	1	88	bpion	bpion	PROPN
admet-1476	1	89	inc	inc	PROPN
admet-1476	1	90	.	.	PROPN
admet-1476	1	91	,	,	PUNCT
admet-1476	1	92	10	10	NUM
admet-1476	1	93	cook	cook	PROPN
admet-1476	1	94	st	st	PROPN
admet-1476	1	95	.	.	PROPN
admet-1476	1	96	billerica	billerica	PROPN
admet-1476	1	97	,	,	PUNCT
admet-1476	1	98	massachusetts	massachusetts	PROPN
admet-1476	1	99	01821	01821	NUM
admet-1476	1	100	,	,	PUNCT
admet-1476	1	101	united	united	PROPN
admet-1476	1	102	states	states	PROPN
admet-1476	1	103	#	#	SYM
admet-1476	1	104	presently	presently	ADV
admet-1476	1	105	at	at	ADP
admet-1476	1	106	:	:	PUNCT
admet-1476	1	107	schrodinger	schrodinger	PROPN
admet-1476	1	108	,	,	PUNCT
admet-1476	1	109	inc	inc	PROPN
admet-1476	1	110	.	.	PROPN
admet-1476	1	111	,	,	PUNCT
admet-1476	1	112	1540	1540	NUM
admet-1476	1	113	broadway	broadway	NOUN
admet-1476	1	114	,	,	PUNCT
admet-1476	1	115	new	new	PROPN
admet-1476	1	116	york	york	PROPN
admet-1476	1	117	,	,	PUNCT
admet-1476	1	118	new	new	PROPN
admet-1476	1	119	york	york	PROPN
admet-1476	1	120	10036	10036	NUM
admet-1476	1	121	,	,	PUNCT
admet-1476	1	122	united	united	PROPN
admet-1476	1	123	states	states	PROPN
admet-1476	1	124	*	*	PUNCT
admet-1476	1	125	corresponding	correspond	VERB
admet-1476	1	126	authors	author	NOUN
admet-1476	1	127	:	:	PUNCT
admet-1476	1	128	e	e	X
admet-1476	1	129	-	-	NOUN
admet-1476	1	130	mail	mail	NOUN
admet-1476	1	131	:	:	PUNCT
admet-1476	1	132	corinne.jankovsky@boehringer-ingelheim.com	corinne.jankovsky@boehringer-ingelheim.com	X
admet-1476	1	133	;	;	PUNCT
admet-1476	1	134	naveen.k.thakral@gmail.com	naveen.k.thakral@gmail.com	PROPN
admet-1476	1	135	.	.	PROPN
admet-1476	1	136	email	email	NOUN
admet-1476	1	137	(	(	PUNCT
admet-1476	1	138	o.	o.	PROPN
admet-1476	1	139	tsinman	tsinman	PROPN
admet-1476	1	140	):	):	PUNCT
admet-1476	1	141	otsinman@pion-inc.com	otsinman@pion-inc.com	PROPN
admet-1476	1	142	.	.	PUNCT
admet-1476	2	1	received	receive	VERB
admet-1476	2	2	:	:	PUNCT
admet-1476	2	3	august	august	PROPN
admet-1476	2	4	02	02	NUM
admet-1476	2	5	,	,	PUNCT
admet-1476	2	6	2022	2022	NUM
admet-1476	2	7	;	;	PUNCT
admet-1476	2	8	revised	revise	VERB
admet-1476	2	9	:	:	PUNCT
admet-1476	2	10	september	september	PROPN
admet-1476	2	11	26	26	NUM
admet-1476	2	12	,	,	PUNCT
admet-1476	2	13	2022	2022	NUM
admet-1476	2	14	;	;	PUNCT
admet-1476	2	15	published	publish	VERB
admet-1476	2	16	:	:	PUNCT
admet-1476	2	17	october	october	PROPN
admet-1476	2	18	07	07	NUM
admet-1476	2	19	,	,	PUNCT
admet-1476	2	20	2022	2022	NUM
admet-1476	2	21	abstract	abstract	NOUN
admet-1476	2	22	the	the	DET
admet-1476	2	23	intake	intake	NOUN
admet-1476	2	24	of	of	ADP
admet-1476	2	25	food	food	NOUN
admet-1476	2	26	and	and	CCONJ
admet-1476	2	27	meal	meal	NOUN
admet-1476	2	28	type	type	NOUN
admet-1476	2	29	can	can	AUX
admet-1476	2	30	strongly	strongly	ADV
admet-1476	2	31	impact	impact	VERB
admet-1476	2	32	the	the	DET
admet-1476	2	33	bioavailability	bioavailability	NOUN
admet-1476	2	34	of	of	ADP
admet-1476	2	35	orally	orally	ADV
admet-1476	2	36	administered	administer	VERB
admet-1476	2	37	drugs	drug	NOUN
admet-1476	2	38	and	and	CCONJ
admet-1476	2	39	can	can	AUX
admet-1476	2	40	consequently	consequently	ADV
admet-1476	2	41	impact	impact	VERB
admet-1476	2	42	drug	drug	NOUN
admet-1476	2	43	efficacy	efficacy	NOUN
admet-1476	2	44	and	and	CCONJ
admet-1476	2	45	safety	safety	NOUN
admet-1476	2	46	.	.	PUNCT
admet-1476	3	1	during	during	ADP
admet-1476	3	2	the	the	DET
admet-1476	3	3	early	early	ADJ
admet-1476	3	4	stages	stage	NOUN
admet-1476	3	5	of	of	ADP
admet-1476	3	6	drug	drug	NOUN
admet-1476	3	7	development	development	NOUN
admet-1476	3	8	,	,	PUNCT
admet-1476	3	9	only	only	ADV
admet-1476	3	10	a	a	DET
admet-1476	3	11	small	small	ADJ
admet-1476	3	12	amount	amount	NOUN
admet-1476	3	13	of	of	ADP
admet-1476	3	14	drug	drug	NOUN
admet-1476	3	15	substance	substance	NOUN
admet-1476	3	16	is	be	AUX
admet-1476	3	17	available	available	ADJ
admet-1476	3	18	,	,	PUNCT
admet-1476	3	19	and	and	CCONJ
admet-1476	3	20	the	the	DET
admet-1476	3	21	solubility	solubility	NOUN
admet-1476	3	22	difference	difference	NOUN
admet-1476	3	23	between	between	ADP
admet-1476	3	24	fasted	fast	VERB
admet-1476	3	25	state	state	NOUN
admet-1476	3	26	simulated	simulate	VERB
admet-1476	3	27	intestinal	intestinal	ADJ
admet-1476	3	28	fluid	fluid	NOUN
admet-1476	3	29	and	and	CCONJ
admet-1476	3	30	fed	feed	VERB
admet-1476	3	31	state	state	NOUN
admet-1476	3	32	simulated	simulate	VERB
admet-1476	3	33	intestinal	intestinal	ADJ
admet-1476	3	34	fluid	fluid	NOUN
admet-1476	3	35	may	may	AUX
admet-1476	3	36	provide	provide	VERB
admet-1476	3	37	an	an	DET
admet-1476	3	38	early	early	ADJ
admet-1476	3	39	indication	indication	NOUN
admet-1476	3	40	about	about	ADP
admet-1476	3	41	the	the	DET
admet-1476	3	42	probable	probable	ADJ
admet-1476	3	43	food	food	NOUN
admet-1476	3	44	effect	effect	NOUN
admet-1476	3	45	.	.	PUNCT
admet-1476	4	1	but	but	CCONJ
admet-1476	4	2	higher	high	ADJ
admet-1476	4	3	drug	drug	NOUN
admet-1476	4	4	solubility	solubility	NOUN
admet-1476	4	5	in	in	ADP
admet-1476	4	6	fed	fed	PROPN
admet-1476	4	7	state	state	NOUN
admet-1476	4	8	simulated	simulate	VERB
admet-1476	4	9	intestinal	intestinal	ADJ
admet-1476	4	10	fluid	fluid	NOUN
admet-1476	4	11	may	may	AUX
admet-1476	4	12	not	not	PART
admet-1476	4	13	always	always	ADV
admet-1476	4	14	results	result	VERB
admet-1476	4	15	in	in	ADP
admet-1476	4	16	an	an	DET
admet-1476	4	17	increased	increase	VERB
admet-1476	4	18	oral	oral	ADJ
admet-1476	4	19	absorption	absorption	NOUN
admet-1476	4	20	.	.	PUNCT
admet-1476	5	1	in	in	ADP
admet-1476	5	2	the	the	DET
admet-1476	5	3	present	present	ADJ
admet-1476	5	4	research	research	NOUN
admet-1476	5	5	,	,	PUNCT
admet-1476	5	6	we	we	PRON
admet-1476	5	7	demonstrated	demonstrate	VERB
admet-1476	5	8	using	use	VERB
admet-1476	5	9	11	11	NUM
admet-1476	5	10	model	model	NOUN
admet-1476	5	11	compounds	compound	VERB
admet-1476	5	12	that	that	SCONJ
admet-1476	5	13	in	in	ADP
admet-1476	5	14	addition	addition	NOUN
admet-1476	5	15	to	to	ADP
admet-1476	5	16	the	the	DET
admet-1476	5	17	drug	drug	NOUN
admet-1476	5	18	dissolution	dissolution	NOUN
admet-1476	5	19	in	in	ADP
admet-1476	5	20	biorelevant	biorelevant	ADJ
admet-1476	5	21	media	medium	NOUN
admet-1476	5	22	,	,	PUNCT
admet-1476	5	23	the	the	DET
admet-1476	5	24	evaluation	evaluation	NOUN
admet-1476	5	25	of	of	ADP
admet-1476	5	26	the	the	DET
admet-1476	5	27	diffusion	diffusion	NOUN
admet-1476	5	28	flux	flux	NOUN
admet-1476	5	29	of	of	ADP
admet-1476	5	30	a	a	DET
admet-1476	5	31	drug	drug	NOUN
admet-1476	5	32	in	in	ADP
admet-1476	5	33	solution	solution	NOUN
admet-1476	5	34	,	,	PUNCT
admet-1476	5	35	across	across	ADP
admet-1476	5	36	artificial	artificial	ADJ
admet-1476	5	37	lipid	lipid	NOUN
admet-1476	5	38	coated	coat	VERB
admet-1476	5	39	membrane	membrane	NOUN
admet-1476	5	40	,	,	PUNCT
admet-1476	5	41	where	where	SCONJ
admet-1476	5	42	only	only	ADV
admet-1476	5	43	the	the	DET
admet-1476	5	44	unbound	unbound	NOUN
admet-1476	5	45	drug	drug	NOUN
admet-1476	5	46	crosses	cross	VERB
admet-1476	5	47	the	the	DET
admet-1476	5	48	membrane	membrane	NOUN
admet-1476	5	49	,	,	PUNCT
admet-1476	5	50	is	be	AUX
admet-1476	5	51	a	a	DET
admet-1476	5	52	reliable	reliable	ADJ
admet-1476	5	53	way	way	NOUN
admet-1476	5	54	to	to	PART
admet-1476	5	55	predict	predict	VERB
admet-1476	5	56	the	the	DET
admet-1476	5	57	food	food	NOUN
admet-1476	5	58	effect	effect	NOUN
admet-1476	5	59	.	.	PUNCT
admet-1476	6	1	although	although	SCONJ
admet-1476	6	2	,	,	PUNCT
admet-1476	6	3	the	the	DET
admet-1476	6	4	combination	combination	NOUN
admet-1476	6	5	of	of	ADP
admet-1476	6	6	dissolution	dissolution	NOUN
admet-1476	6	7	and	and	CCONJ
admet-1476	6	8	diffusion	diffusion	NOUN
admet-1476	6	9	flux	flux	NOUN
admet-1476	6	10	may	may	AUX
admet-1476	6	11	not	not	PART
admet-1476	6	12	reliably	reliably	ADV
admet-1476	6	13	predict	predict	VERB
admet-1476	6	14	the	the	DET
admet-1476	6	15	food	food	NOUN
admet-1476	6	16	effect	effect	NOUN
admet-1476	6	17	in	in	ADP
admet-1476	6	18	case	case	NOUN
admet-1476	6	19	of	of	ADP
admet-1476	6	20	drugs	drug	NOUN
admet-1476	6	21	undergoing	undergo	VERB
admet-1476	6	22	intestinal	intestinal	ADJ
admet-1476	6	23	metabolism	metabolism	NOUN
admet-1476	6	24	or	or	CCONJ
admet-1476	6	25	when	when	SCONJ
admet-1476	6	26	transporters	transporter	NOUN
admet-1476	6	27	are	be	AUX
admet-1476	6	28	involved	involve	VERB
admet-1476	6	29	in	in	ADP
admet-1476	6	30	the	the	DET
admet-1476	6	31	drug	drug	NOUN
admet-1476	6	32	absorption	absorption	NOUN
admet-1476	6	33	,	,	PUNCT
admet-1476	6	34	the	the	DET
admet-1476	6	35	technique	technique	NOUN
admet-1476	6	36	generally	generally	ADV
admet-1476	6	37	provides	provide	VERB
admet-1476	6	38	good	good	ADJ
admet-1476	6	39	information	information	NOUN
admet-1476	6	40	about	about	ADP
admet-1476	6	41	the	the	DET
admet-1476	6	42	food	food	NOUN
admet-1476	6	43	effect	effect	NOUN
admet-1476	6	44	at	at	ADP
admet-1476	6	45	very	very	ADV
admet-1476	6	46	early	early	ADJ
admet-1476	6	47	stages	stage	NOUN
admet-1476	6	48	of	of	ADP
admet-1476	6	49	drug	drug	NOUN
admet-1476	6	50	development	development	NOUN
admet-1476	6	51	that	that	PRON
admet-1476	6	52	may	may	AUX
admet-1476	6	53	help	help	VERB
admet-1476	6	54	in	in	ADP
admet-1476	6	55	designing	design	VERB
admet-1476	6	56	a	a	DET
admet-1476	6	57	clinical	clinical	ADJ
admet-1476	6	58	plan	plan	NOUN
admet-1476	6	59	by	by	ADP
admet-1476	6	60	adjusting	adjust	VERB
admet-1476	6	61	the	the	DET
admet-1476	6	62	drug	drug	NOUN
admet-1476	6	63	dose	dose	VERB
admet-1476	6	64	in	in	ADP
admet-1476	6	65	the	the	DET
admet-1476	6	66	fed	fed	PROPN
admet-1476	6	67	state	state	NOUN
admet-1476	6	68	.	.	PUNCT
admet-1476	7	1	©	©	X
admet-1476	7	2	2022	2022	NUM
admet-1476	7	3	by	by	ADP
admet-1476	7	4	the	the	DET
admet-1476	7	5	authors	author	NOUN
admet-1476	7	6	.	.	PUNCT
admet-1476	8	1	this	this	DET
admet-1476	8	2	article	article	NOUN
admet-1476	8	3	is	be	AUX
admet-1476	8	4	an	an	DET
admet-1476	8	5	open	open	ADJ
admet-1476	8	6	-	-	PUNCT
admet-1476	8	7	access	access	NOUN
admet-1476	8	8	article	article	NOUN
admet-1476	8	9	distributed	distribute	VERB
admet-1476	8	10	under	under	ADP
admet-1476	8	11	the	the	DET
admet-1476	8	12	terms	term	NOUN
admet-1476	8	13	and	and	CCONJ
admet-1476	8	14	conditions	condition	NOUN
admet-1476	8	15	of	of	ADP
admet-1476	8	16	the	the	DET
admet-1476	8	17	creative	creative	ADJ
admet-1476	8	18	commons	common	NOUN
admet-1476	8	19	attribution	attribution	NOUN
admet-1476	8	20	license	license	NOUN
admet-1476	8	21	(	(	PUNCT
admet-1476	8	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1476	8	23	)	)	PUNCT
admet-1476	8	24	.	.	PUNCT
admet-1476	9	1	keywords	keyword	VERB
admet-1476	9	2	food	food	NOUN
admet-1476	9	3	effect	effect	NOUN
admet-1476	9	4	;	;	PUNCT
admet-1476	9	5	bioavailability	bioavailability	NOUN
admet-1476	9	6	;	;	PUNCT
admet-1476	9	7	solubility	solubility	NOUN
admet-1476	9	8	;	;	PUNCT
admet-1476	9	9	biorelevant	biorelevant	NOUN
admet-1476	9	10	medium	medium	NOUN
admet-1476	9	11	;	;	PUNCT
admet-1476	9	12	predictive	predictive	ADJ
admet-1476	9	13	dissolution	dissolution	NOUN
admet-1476	9	14	;	;	PUNCT
admet-1476	9	15	permeability	permeability	NOUN
admet-1476	9	16	;	;	PUNCT
admet-1476	9	17	flux	flux	NOUN
admet-1476	9	18	;	;	PUNCT
admet-1476	9	19	diffusion	diffusion	NOUN
admet-1476	9	20	;	;	PUNCT
admet-1476	9	21	clinical	clinical	ADJ
admet-1476	9	22	trial	trial	NOUN
admet-1476	9	23	introduction	introduction	NOUN
admet-1476	9	24	oral	oral	ADJ
admet-1476	9	25	route	route	NOUN
admet-1476	9	26	of	of	ADP
admet-1476	9	27	drug	drug	NOUN
admet-1476	9	28	administration	administration	NOUN
admet-1476	9	29	is	be	AUX
admet-1476	9	30	convenient	convenient	ADJ
admet-1476	9	31	and	and	CCONJ
admet-1476	9	32	preferred	prefer	VERB
admet-1476	9	33	for	for	ADP
admet-1476	9	34	patient	patient	ADJ
admet-1476	9	35	centric	centric	ADJ
admet-1476	9	36	drug	drug	NOUN
admet-1476	9	37	development	development	NOUN
admet-1476	10	1	[	[	X
admet-1476	10	2	1	1	NUM
admet-1476	10	3	]	]	PUNCT
admet-1476	10	4	.	.	PUNCT
admet-1476	11	1	but	but	CCONJ
admet-1476	11	2	there	there	PRON
admet-1476	11	3	is	be	VERB
admet-1476	11	4	high	high	ADJ
admet-1476	11	5	drug	drug	NOUN
admet-1476	11	6	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	11	7	(	(	PUNCT
admet-1476	11	8	pk	pk	NOUN
admet-1476	11	9	)	)	PUNCT
admet-1476	11	10	variability	variability	NOUN
admet-1476	11	11	associated	associate	VERB
admet-1476	11	12	with	with	ADP
admet-1476	11	13	the	the	DET
admet-1476	11	14	oral	oral	ADJ
admet-1476	11	15	route	route	NOUN
admet-1476	11	16	.	.	PUNCT
admet-1476	12	1	the	the	DET
admet-1476	12	2	oral	oral	ADJ
admet-1476	12	3	drug	drug	NOUN
admet-1476	12	4	absorption	absorption	NOUN
admet-1476	12	5	may	may	AUX
admet-1476	12	6	be	be	AUX
admet-1476	12	7	influenced	influence	VERB
admet-1476	12	8	by	by	ADP
admet-1476	12	9	many	many	ADJ
admet-1476	12	10	intrinsic	intrinsic	ADJ
admet-1476	12	11	and	and	CCONJ
admet-1476	12	12	extrinsic	extrinsic	ADJ
admet-1476	12	13	factors	factor	NOUN
admet-1476	12	14	,	,	PUNCT
admet-1476	12	15	thereby	thereby	ADV
admet-1476	12	16	inducing	induce	VERB
admet-1476	12	17	the	the	DET
admet-1476	12	18	variability	variability	NOUN
admet-1476	12	19	in	in	ADP
admet-1476	12	20	1	1	NUM
admet-1476	12	21	the	the	DET
admet-1476	12	22	authors	author	NOUN
admet-1476	12	23	dedicate	dedicate	VERB
admet-1476	12	24	this	this	DET
admet-1476	12	25	research	research	NOUN
admet-1476	12	26	to	to	ADP
admet-1476	12	27	the	the	DET
admet-1476	12	28	bright	bright	ADJ
admet-1476	12	29	memory	memory	NOUN
admet-1476	12	30	of	of	ADP
admet-1476	12	31	a	a	DET
admet-1476	12	32	very	very	ADV
admet-1476	12	33	kind	kind	ADJ
admet-1476	12	34	human	human	ADJ
admet-1476	12	35	being	being	NOUN
admet-1476	12	36	and	and	CCONJ
admet-1476	12	37	great	great	ADJ
admet-1476	12	38	scientist	scientist	NOUN
admet-1476	12	39	dr	dr	PROPN
admet-1476	12	40	.	.	PROPN
admet-1476	12	41	konstantin	konstantin	PROPN
admet-1476	12	42	tsinman	tsinman	PROPN
admet-1476	12	43	.	.	PUNCT
admet-1476	13	1	dr	dr	PROPN
admet-1476	13	2	.	.	PROPN
admet-1476	13	3	tsinman	tsinman	PROPN
admet-1476	13	4	's	's	PART
admet-1476	13	5	contributions	contribution	NOUN
admet-1476	13	6	to	to	ADP
admet-1476	13	7	the	the	DET
admet-1476	13	8	in	in	X
admet-1476	13	9	vitro	vitro	X
admet-1476	13	10	predictive	predictive	ADJ
admet-1476	13	11	technologies	technology	NOUN
admet-1476	13	12	will	will	AUX
admet-1476	13	13	always	always	ADV
admet-1476	13	14	help	help	VERB
admet-1476	13	15	the	the	DET
admet-1476	13	16	pharmaceutical	pharmaceutical	ADJ
admet-1476	13	17	development	development	NOUN
admet-1476	13	18	scientists	scientist	NOUN
admet-1476	13	19	to	to	PART
admet-1476	13	20	expedite	expedite	VERB
admet-1476	13	21	the	the	DET
admet-1476	13	22	drug	drug	NOUN
admet-1476	13	23	development	development	NOUN
admet-1476	13	24	.	.	PUNCT
admet-1476	14	1	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	DET
admet-1476	14	2	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	PROPN
admet-1476	14	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1476	14	4	mailto:corinne.jankovsky@boehringer-ingelheim.com	mailto:corinne.jankovsky@boehringer-ingelheim.com	X
admet-1476	14	5	mailto:naveen.k.thakral@gmail.com	mailto:naveen.k.thakral@gmail.com	PROPN
admet-1476	14	6	mailto:otsinman@pion-inc.com	mailto:otsinman@pion-inc.com	PROPN
admet-1476	14	7	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1476	14	8	c.	c.	PROPN
admet-1476	14	9	jankovsky	jankovsky	PROPN
admet-1476	14	10	et	et	PROPN
admet-1476	14	11	al	al	PROPN
admet-1476	14	12	.	.	PROPN
admet-1476	14	13	admet	admet	PROPN
admet-1476	14	14	&	&	CCONJ
admet-1476	14	15	dmpk	dmpk	PROPN
admet-1476	14	16	10(4	10(4	NUM
admet-1476	14	17	)	)	PUNCT
admet-1476	14	18	(	(	PUNCT
admet-1476	14	19	2022	2022	NUM
admet-1476	14	20	)	)	PUNCT
admet-1476	14	21	299	299	NUM
admet-1476	14	22	-	-	SYM
admet-1476	14	23	314	314	NUM
admet-1476	14	24	300	300	NUM
admet-1476	14	25	systemic	systemic	ADJ
admet-1476	14	26	drug	drug	NOUN
admet-1476	14	27	exposure	exposure	NOUN
admet-1476	14	28	.	.	PUNCT
admet-1476	15	1	food	food	NOUN
admet-1476	15	2	is	be	AUX
admet-1476	15	3	one	one	NUM
admet-1476	15	4	of	of	ADP
admet-1476	15	5	the	the	DET
admet-1476	15	6	prime	prime	ADJ
admet-1476	15	7	extrinsic	extrinsic	ADJ
admet-1476	15	8	factors	factor	NOUN
admet-1476	15	9	that	that	PRON
admet-1476	15	10	influence	influence	VERB
admet-1476	15	11	the	the	DET
admet-1476	15	12	oral	oral	ADJ
admet-1476	15	13	drug	drug	NOUN
admet-1476	15	14	absorption	absorption	NOUN
admet-1476	15	15	.	.	PUNCT
admet-1476	16	1	food	food	NOUN
admet-1476	16	2	intake	intake	NOUN
admet-1476	16	3	alters	alter	VERB
admet-1476	16	4	the	the	DET
admet-1476	16	5	gastrointestinal	gastrointestinal	ADJ
admet-1476	16	6	environment	environment	NOUN
admet-1476	16	7	,	,	PUNCT
admet-1476	16	8	for	for	ADP
admet-1476	16	9	instance	instance	NOUN
admet-1476	16	10	,	,	PUNCT
admet-1476	16	11	stomach	stomach	NOUN
admet-1476	16	12	ph	ph	VERB
admet-1476	16	13	,	,	PUNCT
admet-1476	16	14	chyme	chyme	NOUN
admet-1476	16	15	viscosity	viscosity	NOUN
admet-1476	16	16	,	,	PUNCT
admet-1476	16	17	bile	bile	NOUN
admet-1476	16	18	concentration	concentration	NOUN
admet-1476	16	19	and	and	CCONJ
admet-1476	16	20	luminal	luminal	ADJ
admet-1476	16	21	fluid	fluid	NOUN
admet-1476	16	22	volume	volume	NOUN
admet-1476	16	23	.	.	PUNCT
admet-1476	17	1	food	food	NOUN
admet-1476	17	2	intake	intake	NOUN
admet-1476	17	3	is	be	AUX
admet-1476	17	4	also	also	ADV
admet-1476	17	5	associated	associate	VERB
admet-1476	17	6	with	with	ADP
admet-1476	17	7	the	the	DET
admet-1476	17	8	physiological	physiological	ADJ
admet-1476	17	9	and	and	CCONJ
admet-1476	17	10	sensory	sensory	ADJ
admet-1476	17	11	responses	response	NOUN
admet-1476	17	12	such	such	ADJ
admet-1476	17	13	as	as	ADP
admet-1476	17	14	prolonged	prolong	VERB
admet-1476	17	15	gastric	gastric	ADJ
admet-1476	17	16	emptying	emptying	NOUN
admet-1476	17	17	time	time	NOUN
admet-1476	17	18	,	,	PUNCT
admet-1476	17	19	increased	increase	VERB
admet-1476	17	20	splanchnic	splanchnic	ADJ
admet-1476	17	21	blood	blood	NOUN
admet-1476	17	22	flow	flow	NOUN
admet-1476	17	23	,	,	PUNCT
admet-1476	17	24	and	and	CCONJ
admet-1476	17	25	change	change	NOUN
admet-1476	17	26	in	in	ADP
admet-1476	17	27	metabolizing	metabolize	VERB
admet-1476	17	28	enzyme	enzyme	NOUN
admet-1476	17	29	activity	activity	NOUN
admet-1476	17	30	,	,	PUNCT
admet-1476	17	31	in	in	ADP
admet-1476	17	32	addition	addition	NOUN
admet-1476	17	33	to	to	ADP
admet-1476	17	34	the	the	DET
admet-1476	17	35	altered	altered	ADJ
admet-1476	17	36	hydrodynamics	hydrodynamic	NOUN
admet-1476	17	37	.	.	PUNCT
admet-1476	18	1	food	food	NOUN
admet-1476	18	2	components	component	NOUN
admet-1476	18	3	may	may	AUX
admet-1476	18	4	interact	interact	VERB
admet-1476	18	5	with	with	ADP
admet-1476	18	6	drugs	drug	NOUN
admet-1476	18	7	to	to	PART
admet-1476	18	8	form	form	VERB
admet-1476	18	9	complex	complex	ADJ
admet-1476	18	10	and	and	CCONJ
admet-1476	18	11	can	can	AUX
admet-1476	18	12	also	also	ADV
admet-1476	18	13	influence	influence	VERB
admet-1476	18	14	their	their	PRON
admet-1476	18	15	physicochemical	physicochemical	ADJ
admet-1476	18	16	properties	property	NOUN
admet-1476	18	17	like	like	ADP
admet-1476	18	18	dissolution	dissolution	NOUN
admet-1476	18	19	rate	rate	NOUN
admet-1476	18	20	,	,	PUNCT
admet-1476	18	21	and	and	CCONJ
admet-1476	18	22	ionization	ionization	NOUN
admet-1476	18	23	state	state	NOUN
admet-1476	18	24	[	[	X
admet-1476	18	25	2,3	2,3	NUM
admet-1476	18	26	]	]	PUNCT
admet-1476	18	27	.	.	PUNCT
admet-1476	19	1	this	this	DET
admet-1476	19	2	complex	complex	ADJ
admet-1476	19	3	interplay	interplay	NOUN
admet-1476	19	4	of	of	ADP
admet-1476	19	5	altered	altered	ADJ
admet-1476	19	6	gastrointestinal	gastrointestinal	ADJ
admet-1476	19	7	milieu	milieu	NOUN
admet-1476	19	8	,	,	PUNCT
admet-1476	19	9	drug	drug	NOUN
admet-1476	19	10	properties	property	NOUN
admet-1476	19	11	and	and	CCONJ
admet-1476	19	12	physiological	physiological	ADJ
admet-1476	19	13	responses	response	NOUN
admet-1476	19	14	may	may	AUX
admet-1476	19	15	impact	impact	VERB
admet-1476	19	16	the	the	DET
admet-1476	19	17	drug	drug	NOUN
admet-1476	19	18	absorption	absorption	NOUN
admet-1476	19	19	in	in	ADP
admet-1476	19	20	the	the	DET
admet-1476	19	21	fed	fed	PROPN
admet-1476	19	22	state	state	NOUN
admet-1476	19	23	.	.	PUNCT
admet-1476	20	1	the	the	DET
admet-1476	20	2	food	food	NOUN
admet-1476	20	3	may	may	AUX
admet-1476	20	4	influence	influence	VERB
admet-1476	20	5	the	the	DET
admet-1476	20	6	drug	drug	NOUN
admet-1476	20	7	absorption	absorption	NOUN
admet-1476	20	8	in	in	ADP
admet-1476	20	9	three	three	NUM
admet-1476	20	10	ways	way	NOUN
admet-1476	20	11	–	–	PUNCT
admet-1476	20	12	reduced	reduce	VERB
admet-1476	20	13	and	and	CCONJ
admet-1476	20	14	delayed	delay	VERB
admet-1476	20	15	(	(	PUNCT
admet-1476	20	16	negative	negative	ADJ
admet-1476	20	17	food	food	NOUN
admet-1476	20	18	effect	effect	NOUN
admet-1476	20	19	)	)	PUNCT
admet-1476	21	1	[	[	X
admet-1476	21	2	4	4	NUM
admet-1476	21	3	]	]	PUNCT
admet-1476	21	4	,	,	PUNCT
admet-1476	21	5	increased	increase	VERB
admet-1476	21	6	and	and	CCONJ
admet-1476	21	7	accelerated	accelerate	VERB
admet-1476	21	8	(	(	PUNCT
admet-1476	21	9	positive	positive	ADJ
admet-1476	21	10	food	food	NOUN
admet-1476	21	11	effect	effect	NOUN
admet-1476	21	12	)	)	PUNCT
admet-1476	22	1	[	[	X
admet-1476	22	2	5	5	NUM
admet-1476	22	3	]	]	PUNCT
admet-1476	22	4	,	,	PUNCT
admet-1476	22	5	or	or	CCONJ
admet-1476	22	6	no	no	DET
admet-1476	22	7	food	food	NOUN
admet-1476	22	8	effect	effect	NOUN
admet-1476	22	9	[	[	X
admet-1476	22	10	6	6	NUM
admet-1476	22	11	]	]	PUNCT
admet-1476	22	12	.	.	PUNCT
admet-1476	23	1	following	follow	VERB
admet-1476	23	2	food	food	NOUN
admet-1476	23	3	intake	intake	NOUN
admet-1476	23	4	,	,	PUNCT
admet-1476	23	5	bile	bile	NOUN
admet-1476	23	6	salts	salt	NOUN
admet-1476	23	7	and	and	CCONJ
admet-1476	23	8	acid	acid	NOUN
admet-1476	23	9	are	be	AUX
admet-1476	23	10	released	release	VERB
admet-1476	23	11	into	into	ADP
admet-1476	23	12	the	the	DET
admet-1476	23	13	gut	gut	NOUN
admet-1476	23	14	and	and	CCONJ
admet-1476	23	15	emulsify	emulsify	VERB
admet-1476	23	16	dietary	dietary	ADJ
admet-1476	23	17	fat	fat	NOUN
admet-1476	23	18	for	for	ADP
admet-1476	23	19	digestion	digestion	NOUN
admet-1476	23	20	[	[	X
admet-1476	23	21	7	7	NUM
admet-1476	23	22	]	]	PUNCT
admet-1476	23	23	.	.	PUNCT
admet-1476	24	1	the	the	DET
admet-1476	24	2	average	average	ADJ
admet-1476	24	3	bile	bile	NOUN
admet-1476	24	4	salts	salt	NOUN
admet-1476	24	5	concentration	concentration	NOUN
admet-1476	24	6	in	in	ADP
admet-1476	24	7	20	20	NUM
admet-1476	24	8	human	human	ADJ
admet-1476	24	9	volunteers	volunteer	NOUN
admet-1476	24	10	was	be	AUX
admet-1476	24	11	found	find	VERB
admet-1476	24	12	to	to	PART
admet-1476	24	13	be	be	AUX
admet-1476	24	14	4.61	4.61	NUM
admet-1476	24	15	mm	mm	NOUN
admet-1476	24	16	(	(	PUNCT
admet-1476	24	17	fasting	fasting	NOUN
admet-1476	24	18	)	)	PUNCT
admet-1476	24	19	and	and	CCONJ
admet-1476	24	20	12.65	12.65	NUM
admet-1476	24	21	mm	mm	NOUN
admet-1476	24	22	(	(	PUNCT
admet-1476	24	23	fed	fed	PROPN
admet-1476	24	24	)	)	PUNCT
admet-1476	25	1	[	[	X
admet-1476	25	2	8	8	NUM
admet-1476	25	3	]	]	PUNCT
admet-1476	25	4	.	.	PUNCT
admet-1476	26	1	higher	high	ADJ
admet-1476	26	2	concentration	concentration	NOUN
admet-1476	26	3	of	of	ADP
admet-1476	26	4	bile	bile	NOUN
admet-1476	26	5	salts	salt	NOUN
admet-1476	26	6	and	and	CCONJ
admet-1476	26	7	acid	acid	VERB
admet-1476	26	8	in	in	ADP
admet-1476	26	9	fed	fed	PROPN
admet-1476	26	10	state	state	NOUN
admet-1476	26	11	helps	help	VERB
admet-1476	26	12	in	in	ADP
admet-1476	26	13	the	the	DET
admet-1476	26	14	solubilization	solubilization	NOUN
admet-1476	26	15	of	of	ADP
admet-1476	26	16	the	the	DET
admet-1476	26	17	poorly	poorly	ADV
admet-1476	26	18	water	water	NOUN
admet-1476	26	19	-	-	PUNCT
admet-1476	26	20	soluble	soluble	ADJ
admet-1476	26	21	drugs	drug	NOUN
admet-1476	26	22	through	through	ADP
admet-1476	26	23	micelle	micelle	NOUN
admet-1476	26	24	formation	formation	NOUN
admet-1476	27	1	[	[	X
admet-1476	27	2	3	3	NUM
admet-1476	27	3	]	]	PUNCT
admet-1476	27	4	.	.	PUNCT
admet-1476	28	1	but	but	CCONJ
admet-1476	28	2	solubilization	solubilization	NOUN
admet-1476	28	3	of	of	ADP
admet-1476	28	4	drugs	drug	NOUN
admet-1476	28	5	may	may	AUX
admet-1476	28	6	not	not	PART
admet-1476	28	7	always	always	ADV
admet-1476	28	8	increase	increase	VERB
admet-1476	28	9	their	their	PRON
admet-1476	28	10	oral	oral	ADJ
admet-1476	28	11	absorption	absorption	NOUN
admet-1476	28	12	.	.	PUNCT
admet-1476	29	1	the	the	DET
admet-1476	29	2	bile	bile	NOUN
admet-1476	29	3	micelles	micelle	NOUN
admet-1476	29	4	may	may	AUX
admet-1476	29	5	“	"	PUNCT
admet-1476	29	6	entrap	entrap	VERB
admet-1476	29	7	”	"	PUNCT
admet-1476	29	8	and	and	CCONJ
admet-1476	29	9	reduce	reduce	VERB
admet-1476	29	10	the	the	DET
admet-1476	29	11	free	free	ADJ
admet-1476	29	12	drug	drug	NOUN
admet-1476	29	13	concentration	concentration	NOUN
admet-1476	29	14	available	available	ADJ
admet-1476	29	15	at	at	ADP
admet-1476	29	16	the	the	DET
admet-1476	29	17	epithelial	epithelial	ADJ
admet-1476	29	18	membrane	membrane	NOUN
admet-1476	29	19	surface	surface	NOUN
admet-1476	29	20	.	.	PUNCT
admet-1476	30	1	micelle	micelle	NOUN
admet-1476	30	2	formation	formation	NOUN
admet-1476	30	3	may	may	AUX
admet-1476	30	4	also	also	ADV
admet-1476	30	5	reduce	reduce	VERB
admet-1476	30	6	the	the	DET
admet-1476	30	7	diffusion	diffusion	NOUN
admet-1476	30	8	coefficient	coefficient	NOUN
admet-1476	30	9	of	of	ADP
admet-1476	30	10	the	the	DET
admet-1476	30	11	drug	drug	NOUN
admet-1476	30	12	in	in	ADP
admet-1476	30	13	the	the	DET
admet-1476	30	14	unstirred	unstirred	ADJ
admet-1476	30	15	water	water	NOUN
admet-1476	30	16	layer	layer	NOUN
admet-1476	30	17	adjacent	adjacent	ADJ
admet-1476	30	18	to	to	ADP
admet-1476	30	19	the	the	DET
admet-1476	30	20	epithelial	epithelial	ADJ
admet-1476	30	21	membrane	membrane	NOUN
admet-1476	30	22	and	and	CCONJ
admet-1476	30	23	may	may	AUX
admet-1476	30	24	lead	lead	VERB
admet-1476	30	25	to	to	ADP
admet-1476	30	26	a	a	DET
admet-1476	30	27	decrease	decrease	NOUN
admet-1476	30	28	in	in	ADP
admet-1476	30	29	effective	effective	ADJ
admet-1476	30	30	permeability	permeability	NOUN
admet-1476	30	31	.	.	PUNCT
admet-1476	31	1	kiyohiko	kiyohiko	PROPN
admet-1476	31	2	sugano	sugano	PROPN
admet-1476	31	3	reviewed	review	VERB
admet-1476	31	4	the	the	DET
admet-1476	31	5	effect	effect	NOUN
admet-1476	31	6	of	of	ADP
admet-1476	31	7	bile	bile	NOUN
admet-1476	31	8	micelles	micelle	NOUN
admet-1476	31	9	on	on	ADP
admet-1476	31	10	solubility	solubility	NOUN
admet-1476	31	11	,	,	PUNCT
admet-1476	31	12	dissolution	dissolution	NOUN
admet-1476	31	13	rate	rate	NOUN
admet-1476	31	14	and	and	CCONJ
admet-1476	31	15	permeability	permeability	NOUN
admet-1476	31	16	,	,	PUNCT
admet-1476	31	17	and	and	CCONJ
admet-1476	31	18	thereby	thereby	ADV
admet-1476	31	19	overall	overall	ADJ
admet-1476	31	20	food	food	NOUN
admet-1476	31	21	effect	effect	NOUN
admet-1476	31	22	on	on	ADP
admet-1476	31	23	the	the	DET
admet-1476	31	24	oral	oral	ADJ
admet-1476	31	25	drug	drug	NOUN
admet-1476	31	26	absorption	absorption	NOUN
admet-1476	31	27	[	[	X
admet-1476	31	28	9,10	9,10	NUM
admet-1476	31	29	]	]	X
admet-1476	31	30	.	.	PUNCT
admet-1476	32	1	high	high	ADJ
admet-1476	32	2	fat	fat	ADJ
admet-1476	32	3	contents	content	NOUN
admet-1476	32	4	of	of	ADP
admet-1476	32	5	food	food	NOUN
admet-1476	32	6	may	may	AUX
admet-1476	32	7	also	also	ADV
admet-1476	32	8	result	result	VERB
admet-1476	32	9	in	in	ADP
admet-1476	32	10	an	an	DET
admet-1476	32	11	inhibitory	inhibitory	ADJ
admet-1476	32	12	effect	effect	NOUN
admet-1476	32	13	on	on	ADP
admet-1476	32	14	intestinal	intestinal	ADJ
admet-1476	32	15	efflux	efflux	NOUN
admet-1476	32	16	transporters	transporter	NOUN
admet-1476	32	17	and	and	CCONJ
admet-1476	32	18	hence	hence	ADV
admet-1476	32	19	increase	increase	VERB
admet-1476	32	20	in	in	ADP
admet-1476	32	21	the	the	DET
admet-1476	32	22	bioavailability	bioavailability	NOUN
admet-1476	32	23	of	of	ADP
admet-1476	32	24	drugs	drug	NOUN
admet-1476	32	25	that	that	PRON
admet-1476	32	26	are	be	AUX
admet-1476	32	27	substrate	substrate	NOUN
admet-1476	32	28	of	of	ADP
admet-1476	32	29	these	these	DET
admet-1476	32	30	efflux	efflux	ADJ
admet-1476	32	31	transporters	transporter	NOUN
admet-1476	32	32	.	.	PUNCT
admet-1476	33	1	on	on	ADP
admet-1476	33	2	similar	similar	ADJ
admet-1476	33	3	lines	line	NOUN
admet-1476	33	4	inhibition	inhibition	NOUN
admet-1476	33	5	of	of	ADP
admet-1476	33	6	uptake	uptake	ADJ
admet-1476	33	7	transporters	transporter	NOUN
admet-1476	33	8	by	by	ADP
admet-1476	33	9	fat	fat	ADJ
admet-1476	33	10	contents	content	NOUN
admet-1476	33	11	may	may	AUX
admet-1476	33	12	lead	lead	VERB
admet-1476	33	13	to	to	PART
admet-1476	33	14	decrease	decrease	VERB
admet-1476	33	15	in	in	ADP
admet-1476	33	16	bioavailability	bioavailability	NOUN
admet-1476	33	17	of	of	ADP
admet-1476	33	18	drugs	drug	NOUN
admet-1476	33	19	reliant	reliant	ADJ
admet-1476	33	20	of	of	ADP
admet-1476	33	21	these	these	DET
admet-1476	33	22	transporters	transporter	NOUN
admet-1476	33	23	for	for	ADP
admet-1476	33	24	the	the	DET
admet-1476	33	25	absorption	absorption	NOUN
admet-1476	33	26	[	[	X
admet-1476	33	27	11	11	NUM
admet-1476	33	28	]	]	PUNCT
admet-1476	33	29	.	.	PUNCT
admet-1476	34	1	in	in	ADP
admet-1476	34	2	several	several	ADJ
admet-1476	34	3	cases	case	NOUN
admet-1476	34	4	negative	negative	ADJ
admet-1476	34	5	food	food	NOUN
admet-1476	34	6	effect	effect	NOUN
admet-1476	34	7	has	have	AUX
admet-1476	34	8	been	be	AUX
admet-1476	34	9	observed	observe	VERB
admet-1476	34	10	for	for	ADP
admet-1476	34	11	the	the	DET
admet-1476	34	12	drugs	drug	NOUN
admet-1476	34	13	that	that	PRON
admet-1476	34	14	are	be	AUX
admet-1476	34	15	substrate	substrate	NOUN
admet-1476	34	16	to	to	ADP
admet-1476	34	17	the	the	DET
admet-1476	34	18	efflux	efflux	ADJ
admet-1476	34	19	transporters	transporter	NOUN
admet-1476	34	20	.	.	PUNCT
admet-1476	35	1	it	it	PRON
admet-1476	35	2	has	have	AUX
admet-1476	35	3	been	be	AUX
admet-1476	35	4	reported	report	VERB
admet-1476	35	5	that	that	SCONJ
admet-1476	35	6	the	the	DET
admet-1476	35	7	prolonged	prolonged	ADJ
admet-1476	35	8	gastric	gastric	ADJ
admet-1476	35	9	emptying	emptying	NOUN
admet-1476	35	10	time	time	NOUN
admet-1476	35	11	in	in	ADP
admet-1476	35	12	fed	fed	PROPN
admet-1476	35	13	state	state	NOUN
admet-1476	35	14	leads	lead	VERB
admet-1476	35	15	to	to	ADP
admet-1476	35	16	decreased	decrease	VERB
admet-1476	35	17	drug	drug	NOUN
admet-1476	35	18	concentration	concentration	NOUN
admet-1476	35	19	in	in	ADP
admet-1476	35	20	the	the	DET
admet-1476	35	21	intestinal	intestinal	ADJ
admet-1476	35	22	lumen	luman	NOUN
admet-1476	35	23	to	to	PART
admet-1476	35	24	saturate	saturate	VERB
admet-1476	35	25	the	the	DET
admet-1476	35	26	efflux	efflux	ADJ
admet-1476	35	27	transporters	transporter	NOUN
admet-1476	35	28	,	,	PUNCT
admet-1476	35	29	and	and	CCONJ
admet-1476	35	30	therefore	therefore	ADV
admet-1476	35	31	increase	increase	VERB
admet-1476	35	32	the	the	DET
admet-1476	35	33	drug	drug	NOUN
admet-1476	35	34	transport	transport	NOUN
admet-1476	35	35	efficiency	efficiency	NOUN
admet-1476	35	36	in	in	ADP
admet-1476	35	37	fed	fed	PROPN
admet-1476	35	38	state	state	NOUN
admet-1476	35	39	as	as	SCONJ
admet-1476	35	40	compared	compare	VERB
admet-1476	35	41	to	to	ADP
admet-1476	35	42	the	the	DET
admet-1476	35	43	fasted	fasted	ADJ
admet-1476	35	44	state	state	NOUN
admet-1476	35	45	[	[	X
admet-1476	35	46	3	3	NUM
admet-1476	35	47	]	]	PUNCT
admet-1476	35	48	.	.	PUNCT
admet-1476	36	1	the	the	DET
admet-1476	36	2	change	change	NOUN
admet-1476	36	3	in	in	ADP
admet-1476	36	4	pk	pk	NOUN
admet-1476	36	5	induced	induce	VERB
admet-1476	36	6	by	by	ADP
admet-1476	36	7	co	co	NOUN
admet-1476	36	8	-	-	NOUN
admet-1476	36	9	administration	administration	NOUN
admet-1476	36	10	of	of	ADP
admet-1476	36	11	food	food	NOUN
admet-1476	36	12	can	can	AUX
admet-1476	36	13	have	have	VERB
admet-1476	36	14	serious	serious	ADJ
admet-1476	36	15	repercussion	repercussion	NOUN
admet-1476	36	16	for	for	ADP
admet-1476	36	17	narrow	narrow	ADJ
admet-1476	36	18	therapeutic	therapeutic	ADJ
admet-1476	36	19	-	-	PUNCT
admet-1476	36	20	index	index	NOUN
admet-1476	36	21	drugs	drug	NOUN
admet-1476	36	22	.	.	PUNCT
admet-1476	37	1	a	a	DET
admet-1476	37	2	positive	positive	ADJ
admet-1476	37	3	food	food	NOUN
admet-1476	37	4	effect	effect	NOUN
admet-1476	37	5	may	may	AUX
admet-1476	37	6	compromise	compromise	VERB
admet-1476	37	7	safety	safety	NOUN
admet-1476	37	8	if	if	SCONJ
admet-1476	37	9	systemic	systemic	ADJ
admet-1476	37	10	exposure	exposure	NOUN
admet-1476	37	11	exceeds	exceed	VERB
admet-1476	37	12	maximum	maximum	ADJ
admet-1476	37	13	tolerable	tolerable	ADJ
admet-1476	37	14	dose	dose	NOUN
admet-1476	37	15	.	.	PUNCT
admet-1476	38	1	similarly	similarly	ADV
admet-1476	38	2	,	,	PUNCT
admet-1476	38	3	a	a	DET
admet-1476	38	4	negative	negative	ADJ
admet-1476	38	5	food	food	NOUN
admet-1476	38	6	effect	effect	NOUN
admet-1476	38	7	may	may	AUX
admet-1476	38	8	compromise	compromise	VERB
admet-1476	38	9	efficacy	efficacy	NOUN
admet-1476	38	10	of	of	ADP
admet-1476	38	11	the	the	DET
admet-1476	38	12	drugs	drug	NOUN
admet-1476	38	13	by	by	ADP
admet-1476	38	14	decreasing	decrease	VERB
admet-1476	38	15	the	the	DET
admet-1476	38	16	systemic	systemic	ADJ
admet-1476	38	17	absorption	absorption	NOUN
admet-1476	38	18	[	[	X
admet-1476	38	19	5	5	NUM
admet-1476	38	20	]	]	PUNCT
admet-1476	38	21	.	.	PUNCT
admet-1476	39	1	therefore	therefore	ADV
admet-1476	39	2	,	,	PUNCT
admet-1476	39	3	assessing	assess	VERB
admet-1476	39	4	the	the	DET
admet-1476	39	5	effect	effect	NOUN
admet-1476	39	6	of	of	ADP
admet-1476	39	7	food	food	NOUN
admet-1476	39	8	on	on	ADP
admet-1476	39	9	the	the	DET
admet-1476	39	10	absorption	absorption	NOUN
admet-1476	39	11	of	of	ADP
admet-1476	39	12	a	a	DET
admet-1476	39	13	drug	drug	NOUN
admet-1476	39	14	is	be	AUX
admet-1476	39	15	critical	critical	ADJ
admet-1476	39	16	to	to	PART
admet-1476	39	17	optimize	optimize	VERB
admet-1476	39	18	the	the	DET
admet-1476	39	19	safety	safety	NOUN
admet-1476	39	20	and	and	CCONJ
admet-1476	39	21	efficacy	efficacy	NOUN
admet-1476	39	22	of	of	ADP
admet-1476	39	23	the	the	DET
admet-1476	39	24	final	final	ADJ
admet-1476	39	25	drug	drug	NOUN
admet-1476	39	26	product	product	NOUN
admet-1476	39	27	.	.	PUNCT
admet-1476	40	1	the	the	DET
admet-1476	40	2	assessment	assessment	NOUN
admet-1476	40	3	is	be	AUX
admet-1476	40	4	also	also	ADV
admet-1476	40	5	important	important	ADJ
admet-1476	40	6	for	for	ADP
admet-1476	40	7	the	the	DET
admet-1476	40	8	accurate	accurate	ADJ
admet-1476	40	9	instructions	instruction	NOUN
admet-1476	40	10	to	to	PART
admet-1476	40	11	be	be	AUX
admet-1476	40	12	provided	provide	VERB
admet-1476	40	13	on	on	ADP
admet-1476	40	14	the	the	DET
admet-1476	40	15	product	product	NOUN
admet-1476	40	16	label	label	NOUN
admet-1476	40	17	for	for	ADP
admet-1476	40	18	drug	drug	NOUN
admet-1476	40	19	administration	administration	NOUN
admet-1476	40	20	in	in	ADP
admet-1476	40	21	relation	relation	NOUN
admet-1476	40	22	to	to	ADP
admet-1476	40	23	food	food	NOUN
admet-1476	40	24	.	.	PUNCT
admet-1476	41	1	the	the	DET
admet-1476	41	2	united	united	PROPN
admet-1476	41	3	states	states	PROPN
admet-1476	41	4	food	food	PROPN
admet-1476	41	5	and	and	CCONJ
admet-1476	41	6	drug	drug	PROPN
admet-1476	41	7	administration	administration	PROPN
admet-1476	41	8	(	(	PUNCT
admet-1476	41	9	fda	fda	PROPN
admet-1476	41	10	)	)	PUNCT
admet-1476	41	11	has	have	AUX
admet-1476	41	12	provided	provide	VERB
admet-1476	41	13	recommendations	recommendation	NOUN
admet-1476	41	14	in	in	ADP
admet-1476	41	15	the	the	DET
admet-1476	41	16	form	form	NOUN
admet-1476	41	17	of	of	ADP
admet-1476	41	18	guidance	guidance	NOUN
admet-1476	41	19	document	document	NOUN
admet-1476	41	20	to	to	PART
admet-1476	41	21	conduct	conduct	VERB
admet-1476	41	22	food	food	NOUN
admet-1476	41	23	-	-	PUNCT
admet-1476	41	24	effect	effect	NOUN
admet-1476	41	25	studies	study	NOUN
admet-1476	41	26	for	for	ADP
admet-1476	41	27	orally	orally	ADV
admet-1476	41	28	administered	administer	VERB
admet-1476	41	29	drug	drug	NOUN
admet-1476	41	30	products	product	NOUN
admet-1476	41	31	as	as	ADP
admet-1476	41	32	part	part	NOUN
admet-1476	41	33	of	of	ADP
admet-1476	41	34	investigational	investigational	ADJ
admet-1476	41	35	new	new	ADJ
admet-1476	41	36	drug	drug	NOUN
admet-1476	41	37	applications	application	NOUN
admet-1476	41	38	(	(	PUNCT
admet-1476	41	39	inds	ind	NOUN
admet-1476	41	40	)	)	PUNCT
admet-1476	41	41	,	,	PUNCT
admet-1476	41	42	new	new	ADJ
admet-1476	41	43	drug	drug	NOUN
admet-1476	41	44	applications	application	NOUN
admet-1476	41	45	(	(	PUNCT
admet-1476	41	46	ndas	ndas	PROPN
admet-1476	41	47	)	)	PUNCT
admet-1476	41	48	,	,	PUNCT
admet-1476	41	49	and	and	CCONJ
admet-1476	41	50	supplements	supplement	NOUN
admet-1476	41	51	to	to	ADP
admet-1476	41	52	these	these	DET
admet-1476	41	53	applications	application	NOUN
admet-1476	41	54	.	.	PUNCT
admet-1476	42	1	the	the	DET
admet-1476	42	2	document	document	NOUN
admet-1476	42	3	recommends	recommend	VERB
admet-1476	42	4	the	the	DET
admet-1476	42	5	assessments	assessment	NOUN
admet-1476	42	6	of	of	ADP
admet-1476	42	7	the	the	DET
admet-1476	42	8	food	food	NOUN
admet-1476	42	9	effect	effect	NOUN
admet-1476	42	10	(	(	PUNCT
admet-1476	42	11	with	with	ADP
admet-1476	42	12	a	a	DET
admet-1476	42	13	high	high	ADJ
admet-1476	42	14	fat	fat	ADJ
admet-1476	42	15	meal	meal	NOUN
admet-1476	42	16	)	)	PUNCT
admet-1476	42	17	on	on	ADP
admet-1476	42	18	a	a	DET
admet-1476	42	19	new	new	ADJ
admet-1476	42	20	drug	drug	NOUN
admet-1476	42	21	during	during	ADP
admet-1476	42	22	phase	phase	NOUN
admet-1476	42	23	1	1	NUM
admet-1476	42	24	clinical	clinical	ADJ
admet-1476	42	25	trials	trial	NOUN
admet-1476	42	26	(	(	PUNCT
admet-1476	42	27	as	as	ADP
admet-1476	42	28	part	part	NOUN
admet-1476	42	29	of	of	ADP
admet-1476	42	30	the	the	DET
admet-1476	42	31	first	first	ADJ
admet-1476	42	32	-	-	PUNCT
admet-1476	42	33	in	in	ADP
admet-1476	42	34	-	-	PUNCT
admet-1476	42	35	human	human	ADJ
admet-1476	42	36	trials	trial	NOUN
admet-1476	42	37	)	)	PUNCT
admet-1476	42	38	to	to	PART
admet-1476	42	39	decide	decide	VERB
admet-1476	42	40	if	if	SCONJ
admet-1476	42	41	a	a	DET
admet-1476	42	42	drug	drug	NOUN
admet-1476	42	43	should	should	AUX
admet-1476	42	44	be	be	AUX
admet-1476	42	45	administered	administer	VERB
admet-1476	42	46	with	with	ADP
admet-1476	42	47	food	food	NOUN
admet-1476	42	48	in	in	ADP
admet-1476	42	49	the	the	DET
admet-1476	42	50	trials	trial	NOUN
admet-1476	42	51	until	until	SCONJ
admet-1476	42	52	a	a	DET
admet-1476	42	53	final	final	ADJ
admet-1476	42	54	commercial	commercial	ADJ
admet-1476	42	55	formulation	formulation	NOUN
admet-1476	42	56	is	be	AUX
admet-1476	42	57	identified	identify	VERB
admet-1476	42	58	.	.	PUNCT
admet-1476	43	1	for	for	ADP
admet-1476	43	2	the	the	DET
admet-1476	43	3	data	datum	NOUN
admet-1476	43	4	analyses	analyse	VERB
admet-1476	43	5	the	the	DET
admet-1476	43	6	guidance	guidance	NOUN
admet-1476	43	7	document	document	NOUN
admet-1476	43	8	recommends	recommend	VERB
admet-1476	43	9	evaluating	evaluate	VERB
admet-1476	43	10	the	the	DET
admet-1476	43	11	effect	effect	NOUN
admet-1476	43	12	of	of	ADP
admet-1476	43	13	food	food	NOUN
admet-1476	43	14	on	on	ADP
admet-1476	43	15	pk	pk	NOUN
admet-1476	43	16	parameters	parameter	NOUN
admet-1476	43	17	,	,	PUNCT
admet-1476	43	18	including	include	VERB
admet-1476	43	19	total	total	ADJ
admet-1476	43	20	exposure	exposure	NOUN
admet-1476	43	21	of	of	ADP
admet-1476	43	22	the	the	DET
admet-1476	43	23	drug	drug	NOUN
admet-1476	43	24	(	(	PUNCT
admet-1476	43	25	area	area	NOUN
admet-1476	43	26	under	under	ADP
admet-1476	43	27	the	the	DET
admet-1476	43	28	curve	curve	NOUN
admet-1476	43	29	;	;	PUNCT
admet-1476	43	30	auc0-∞	auc0-∞	NUM
admet-1476	43	31	,	,	PUNCT
admet-1476	43	32	auc0	auc0	PROPN
admet-1476	43	33	-	-	PUNCT
admet-1476	43	34	t	t	PROPN
admet-1476	43	35	)	)	PUNCT
admet-1476	43	36	,	,	PUNCT
admet-1476	43	37	the	the	DET
admet-1476	43	38	peak	peak	NOUN
admet-1476	43	39	concentration	concentration	NOUN
admet-1476	43	40	of	of	ADP
admet-1476	43	41	the	the	DET
admet-1476	43	42	drug	drug	NOUN
admet-1476	43	43	and	and	CCONJ
admet-1476	43	44	time	time	NOUN
admet-1476	43	45	to	to	PART
admet-1476	43	46	peak	peak	VERB
admet-1476	43	47	(	(	PUNCT
admet-1476	43	48	cmax	cmax	NOUN
admet-1476	43	49	and	and	CCONJ
admet-1476	43	50	tmax	tmax	NUM
admet-1476	43	51	)	)	PUNCT
admet-1476	43	52	,	,	PUNCT
admet-1476	43	53	terminal	terminal	ADJ
admet-1476	43	54	elimination	elimination	NOUN
admet-1476	43	55	half	half	ADJ
admet-1476	43	56	-	-	PUNCT
admet-1476	43	57	life	life	NOUN
admet-1476	43	58	(	(	PUNCT
admet-1476	43	59	t1/2	t1/2	PROPN
admet-1476	43	60	)	)	PUNCT
admet-1476	43	61	,	,	PUNCT
admet-1476	43	62	the	the	DET
admet-1476	43	63	apparent	apparent	ADJ
admet-1476	43	64	clearance	clearance	NOUN
admet-1476	43	65	,	,	PUNCT
admet-1476	43	66	the	the	DET
admet-1476	43	67	apparent	apparent	ADJ
admet-1476	43	68	volume	volume	NOUN
admet-1476	43	69	of	of	ADP
admet-1476	43	70	distribution	distribution	NOUN
admet-1476	43	71	,	,	PUNCT
admet-1476	43	72	and	and	CCONJ
admet-1476	43	73	lag	lag	NOUN
admet-1476	43	74	-	-	PUNCT
admet-1476	43	75	time	time	NOUN
admet-1476	43	76	in	in	ADP
admet-1476	43	77	achieving	achieve	VERB
admet-1476	43	78	tmax	tmax	ADP
admet-1476	43	79	(	(	PUNCT
admet-1476	43	80	tlag	tlag	NOUN
admet-1476	43	81	)	)	PUNCT
admet-1476	43	82	.	.	PUNCT
admet-1476	44	1	based	base	VERB
admet-1476	44	2	on	on	ADP
admet-1476	44	3	log	log	NOUN
admet-1476	44	4	transformed	transform	VERB
admet-1476	44	5	data	datum	NOUN
admet-1476	44	6	,	,	PUNCT
admet-1476	44	7	when	when	SCONJ
admet-1476	44	8	the	the	DET
admet-1476	44	9	90	90	NUM
admet-1476	44	10	percent	percent	NOUN
admet-1476	44	11	confidence	confidence	NOUN
admet-1476	44	12	interval	interval	NOUN
admet-1476	44	13	for	for	ADP
admet-1476	44	14	the	the	DET
admet-1476	44	15	ratio	ratio	NOUN
admet-1476	44	16	of	of	ADP
admet-1476	44	17	the	the	DET
admet-1476	44	18	population	population	NOUN
admet-1476	44	19	geometric	geometric	ADJ
admet-1476	44	20	means	mean	NOUN
admet-1476	44	21	between	between	ADP
admet-1476	44	22	fed	fed	PROPN
admet-1476	44	23	and	and	CCONJ
admet-1476	44	24	fasted	fast	VERB
admet-1476	44	25	treatments	treatment	NOUN
admet-1476	44	26	fall	fall	VERB
admet-1476	44	27	outside	outside	ADV
admet-1476	44	28	of	of	ADP
admet-1476	44	29	80–125	80–125	NUM
admet-1476	44	30	%	%	NOUN
admet-1476	44	31	for	for	ADP
admet-1476	44	32	auc	auc	NOUN
admet-1476	44	33	(	(	PUNCT
admet-1476	44	34	auc0∞	auc0∞	PROPN
admet-1476	44	35	or	or	CCONJ
admet-1476	44	36	auc0	auc0	PROPN
admet-1476	44	37	-	-	PUNCT
admet-1476	44	38	t	t	PROPN
admet-1476	44	39	when	when	SCONJ
admet-1476	44	40	appropriate	appropriate	ADJ
admet-1476	44	41	)	)	PUNCT
admet-1476	44	42	and	and	CCONJ
admet-1476	44	43	cmax	cmax	NOUN
admet-1476	44	44	,	,	PUNCT
admet-1476	44	45	the	the	DET
admet-1476	44	46	fda	fda	PROPN
admet-1476	44	47	considers	consider	VERB
admet-1476	44	48	the	the	DET
admet-1476	44	49	presence	presence	NOUN
admet-1476	44	50	of	of	ADP
admet-1476	44	51	food	food	NOUN
admet-1476	44	52	effect	effect	NOUN
admet-1476	44	53	.	.	PUNCT
admet-1476	45	1	the	the	DET
admet-1476	45	2	clinical	clinical	ADJ
admet-1476	45	3	significance	significance	NOUN
admet-1476	45	4	admet	admet	PROPN
admet-1476	45	5	&	&	CCONJ
admet-1476	45	6	dmpk	dmpk	PROPN
admet-1476	45	7	x(y	x(y	PROPN
admet-1476	45	8	)	)	PUNCT
admet-1476	45	9	(	(	PUNCT
admet-1476	45	10	20xx	20xx	NOUN
admet-1476	45	11	)	)	PUNCT
admet-1476	45	12	000	000	NUM
admet-1476	45	13	-	-	PUNCT
admet-1476	45	14	000	000	NUM
admet-1476	45	15	material	material	NOUN
admet-1476	45	16	sparing	sparing	NOUN
admet-1476	45	17	µflux	µflux	NOUN
admet-1476	45	18	methodology	methodology	NOUN
admet-1476	45	19	doi	doi	NOUN
admet-1476	45	20	:	:	PUNCT
admet-1476	45	21	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	NOUN
admet-1476	45	22	301	301	NUM
admet-1476	45	23	of	of	ADP
admet-1476	45	24	any	any	DET
admet-1476	45	25	difference	difference	NOUN
admet-1476	45	26	in	in	ADP
admet-1476	45	27	tmax	tmax	NOUN
admet-1476	45	28	and	and	CCONJ
admet-1476	45	29	tlag	tlag	NOUN
admet-1476	45	30	,	,	PUNCT
admet-1476	45	31	if	if	SCONJ
admet-1476	45	32	any	any	PRON
admet-1476	45	33	,	,	PUNCT
admet-1476	45	34	should	should	AUX
admet-1476	45	35	also	also	ADV
admet-1476	45	36	be	be	AUX
admet-1476	45	37	considered	consider	VERB
admet-1476	45	38	[	[	X
admet-1476	45	39	12	12	NUM
admet-1476	45	40	]	]	PUNCT
admet-1476	45	41	.	.	PUNCT
admet-1476	46	1	due	due	ADP
admet-1476	46	2	to	to	ADP
admet-1476	46	3	the	the	DET
admet-1476	46	4	complex	complex	ADJ
admet-1476	46	5	nature	nature	NOUN
admet-1476	46	6	of	of	ADP
admet-1476	46	7	food	food	NOUN
admet-1476	46	8	effect	effect	NOUN
admet-1476	46	9	,	,	PUNCT
admet-1476	46	10	pharmaceutical	pharmaceutical	ADJ
admet-1476	46	11	industry	industry	NOUN
admet-1476	46	12	follows	follow	VERB
admet-1476	46	13	an	an	DET
admet-1476	46	14	integrated	integrated	ADJ
admet-1476	46	15	approach	approach	NOUN
admet-1476	46	16	for	for	ADP
admet-1476	46	17	the	the	DET
admet-1476	46	18	assessment	assessment	NOUN
admet-1476	46	19	during	during	ADP
admet-1476	46	20	early	early	ADJ
admet-1476	46	21	phase	phase	NOUN
admet-1476	46	22	of	of	ADP
admet-1476	46	23	discovery	discovery	NOUN
admet-1476	46	24	and	and	CCONJ
admet-1476	46	25	development	development	NOUN
admet-1476	46	26	.	.	PUNCT
admet-1476	47	1	a	a	DET
admet-1476	47	2	combination	combination	NOUN
admet-1476	47	3	of	of	ADP
admet-1476	47	4	studies	study	NOUN
admet-1476	47	5	in	in	ADP
admet-1476	47	6	preclinical	preclinical	ADJ
admet-1476	47	7	species	specie	NOUN
admet-1476	47	8	,	,	PUNCT
admet-1476	47	9	predictive	predictive	ADJ
admet-1476	47	10	in	in	ADP
admet-1476	47	11	vitro	vitro	X
admet-1476	47	12	models	model	NOUN
admet-1476	47	13	and	and	CCONJ
admet-1476	47	14	physiologically	physiologically	ADV
admet-1476	47	15	based	base	VERB
admet-1476	47	16	absorption	absorption	NOUN
admet-1476	47	17	modeling	modeling	NOUN
admet-1476	47	18	are	be	AUX
admet-1476	47	19	utilized	utilize	VERB
admet-1476	47	20	before	before	ADP
admet-1476	47	21	first	first	ADJ
admet-1476	47	22	-	-	PUNCT
admet-1476	47	23	in	in	ADP
admet-1476	47	24	-	-	PUNCT
admet-1476	47	25	human	human	ADJ
admet-1476	47	26	clinical	clinical	ADJ
admet-1476	47	27	trials	trial	NOUN
admet-1476	47	28	.	.	PUNCT
admet-1476	48	1	fda	fda	PROPN
admet-1476	48	2	has	have	AUX
admet-1476	48	3	provided	provide	VERB
admet-1476	48	4	recommendations	recommendation	NOUN
admet-1476	48	5	for	for	ADP
admet-1476	48	6	the	the	DET
admet-1476	48	7	development	development	NOUN
admet-1476	48	8	of	of	ADP
admet-1476	48	9	clinically	clinically	ADV
admet-1476	48	10	relevant	relevant	ADJ
admet-1476	48	11	dissolution	dissolution	NOUN
admet-1476	48	12	specifications	specification	NOUN
admet-1476	48	13	(	(	PUNCT
admet-1476	48	14	method	method	NOUN
admet-1476	48	15	and	and	CCONJ
admet-1476	48	16	acceptance	acceptance	NOUN
admet-1476	48	17	criteria	criterion	NOUN
admet-1476	48	18	)	)	PUNCT
admet-1476	48	19	,	,	PUNCT
admet-1476	48	20	and	and	CCONJ
admet-1476	48	21	for	for	ADP
admet-1476	48	22	the	the	DET
admet-1476	48	23	development	development	NOUN
admet-1476	48	24	,	,	PUNCT
admet-1476	48	25	evaluation	evaluation	NOUN
admet-1476	48	26	,	,	PUNCT
admet-1476	48	27	and	and	CCONJ
admet-1476	48	28	use	use	NOUN
admet-1476	48	29	of	of	ADP
admet-1476	48	30	physiologically	physiologically	ADV
admet-1476	48	31	based	base	VERB
admet-1476	48	32	pharmacokinetic	pharmacokinetic	ADJ
admet-1476	48	33	(	(	PUNCT
admet-1476	48	34	pbpk	pbpk	NOUN
admet-1476	48	35	)	)	PUNCT
admet-1476	48	36	analyses	analysis	NOUN
admet-1476	48	37	for	for	ADP
admet-1476	48	38	biopharmaceutics	biopharmaceutics	NOUN
admet-1476	48	39	applications	application	NOUN
admet-1476	48	40	in	in	ADP
admet-1476	48	41	support	support	NOUN
admet-1476	48	42	of	of	ADP
admet-1476	48	43	drug	drug	NOUN
admet-1476	48	44	product	product	NOUN
admet-1476	48	45	development	development	NOUN
admet-1476	48	46	[	[	X
admet-1476	48	47	13	13	NUM
admet-1476	48	48	]	]	PUNCT
admet-1476	48	49	.	.	PUNCT
admet-1476	49	1	various	various	ADJ
admet-1476	49	2	in	in	ADP
admet-1476	49	3	silico	silico	NOUN
admet-1476	49	4	,	,	PUNCT
admet-1476	49	5	in	in	ADP
admet-1476	49	6	vitro	vitro	NOUN
admet-1476	49	7	,	,	PUNCT
admet-1476	49	8	and	and	CCONJ
admet-1476	49	9	in	in	ADP
admet-1476	49	10	vivo	vivo	ADJ
admet-1476	49	11	tools	tool	NOUN
admet-1476	49	12	and	and	CCONJ
admet-1476	49	13	techniques	technique	NOUN
admet-1476	49	14	have	have	AUX
admet-1476	49	15	been	be	AUX
admet-1476	49	16	reviewed	review	VERB
admet-1476	49	17	for	for	ADP
admet-1476	49	18	the	the	DET
admet-1476	49	19	food	food	NOUN
admet-1476	49	20	effect	effect	NOUN
admet-1476	49	21	prediction	prediction	NOUN
admet-1476	49	22	during	during	ADP
admet-1476	49	23	drug	drug	NOUN
admet-1476	49	24	development	development	NOUN
admet-1476	49	25	[	[	X
admet-1476	49	26	2,14	2,14	NUM
admet-1476	49	27	]	]	PUNCT
admet-1476	49	28	.	.	PUNCT
admet-1476	50	1	characterization	characterization	NOUN
admet-1476	50	2	of	of	ADP
admet-1476	50	3	the	the	DET
admet-1476	50	4	luminal	luminal	ADJ
admet-1476	50	5	environment	environment	NOUN
admet-1476	50	6	after	after	ADP
admet-1476	50	7	food	food	NOUN
admet-1476	50	8	intake	intake	NOUN
admet-1476	50	9	,	,	PUNCT
admet-1476	50	10	selection	selection	NOUN
admet-1476	50	11	of	of	ADP
admet-1476	50	12	appropriate	appropriate	ADJ
admet-1476	50	13	biorelevant	biorelevant	ADJ
admet-1476	50	14	dissolution	dissolution	NOUN
admet-1476	50	15	media	medium	NOUN
admet-1476	50	16	for	for	ADP
admet-1476	50	17	fed	fed	PROPN
admet-1476	50	18	state	state	NOUN
admet-1476	50	19	and	and	CCONJ
admet-1476	50	20	various	various	ADJ
admet-1476	50	21	in	in	ADP
admet-1476	50	22	vitro	vitro	X
admet-1476	50	23	methodologies	methodology	NOUN
admet-1476	50	24	for	for	ADP
admet-1476	50	25	evaluating	evaluate	VERB
admet-1476	50	26	drug	drug	NOUN
admet-1476	50	27	product	product	NOUN
admet-1476	50	28	performance	performance	NOUN
admet-1476	50	29	in	in	ADP
admet-1476	50	30	the	the	DET
admet-1476	50	31	fed	fed	PROPN
admet-1476	50	32	state	state	NOUN
admet-1476	50	33	has	have	AUX
admet-1476	50	34	also	also	ADV
admet-1476	50	35	been	be	AUX
admet-1476	50	36	reviewed	review	VERB
admet-1476	50	37	[	[	PUNCT
admet-1476	50	38	15	15	NUM
admet-1476	50	39	]	]	X
admet-1476	50	40	.	.	PUNCT
admet-1476	51	1	practically	practically	ADV
admet-1476	51	2	,	,	PUNCT
admet-1476	51	3	during	during	ADP
admet-1476	51	4	the	the	DET
admet-1476	51	5	early	early	ADJ
admet-1476	51	6	stages	stage	NOUN
admet-1476	51	7	of	of	ADP
admet-1476	51	8	drug	drug	NOUN
admet-1476	51	9	development	development	NOUN
admet-1476	51	10	only	only	ADV
admet-1476	51	11	a	a	DET
admet-1476	51	12	few	few	ADJ
admet-1476	51	13	milligrams	milligram	NOUN
admet-1476	51	14	of	of	ADP
admet-1476	51	15	drug	drug	NOUN
admet-1476	51	16	substance	substance	NOUN
admet-1476	51	17	(	(	PUNCT
admet-1476	51	18	ds	ds	NOUN
admet-1476	51	19	)	)	PUNCT
admet-1476	51	20	is	be	AUX
admet-1476	51	21	available	available	ADJ
admet-1476	51	22	,	,	PUNCT
admet-1476	51	23	not	not	PART
admet-1476	51	24	sufficient	sufficient	ADJ
admet-1476	51	25	even	even	ADV
admet-1476	51	26	for	for	ADP
admet-1476	51	27	the	the	DET
admet-1476	51	28	pre	pre	ADJ
admet-1476	51	29	-	-	ADJ
admet-1476	51	30	clinical	clinical	ADJ
admet-1476	51	31	formulation	formulation	NOUN
admet-1476	51	32	development	development	NOUN
admet-1476	51	33	.	.	PUNCT
admet-1476	52	1	this	this	PRON
admet-1476	52	2	does	do	AUX
admet-1476	52	3	not	not	PART
admet-1476	52	4	leave	leave	VERB
admet-1476	52	5	a	a	DET
admet-1476	52	6	lot	lot	NOUN
admet-1476	52	7	of	of	ADP
admet-1476	52	8	room	room	NOUN
admet-1476	52	9	to	to	PART
admet-1476	52	10	improve	improve	VERB
admet-1476	52	11	wettability	wettability	NOUN
admet-1476	52	12	and	and	CCONJ
admet-1476	52	13	surface	surface	NOUN
admet-1476	52	14	area	area	NOUN
admet-1476	52	15	limitations	limitation	NOUN
admet-1476	52	16	of	of	ADP
admet-1476	52	17	"	"	PUNCT
admet-1476	52	18	grease	grease	NOUN
admet-1476	52	19	ball	ball	NOUN
admet-1476	52	20	molecules	molecule	NOUN
admet-1476	52	21	"	"	PUNCT
admet-1476	52	22	at	at	ADP
admet-1476	52	23	this	this	DET
admet-1476	52	24	stage	stage	NOUN
admet-1476	52	25	of	of	ADP
admet-1476	52	26	development	development	NOUN
admet-1476	52	27	.	.	PUNCT
admet-1476	53	1	the	the	DET
admet-1476	53	2	commonly	commonly	ADV
admet-1476	53	3	used	use	VERB
admet-1476	53	4	techniques	technique	NOUN
admet-1476	53	5	to	to	PART
admet-1476	53	6	predict	predict	VERB
admet-1476	53	7	the	the	DET
admet-1476	53	8	food	food	NOUN
admet-1476	53	9	effect	effect	NOUN
admet-1476	53	10	[	[	X
admet-1476	53	11	2,14	2,14	X
admet-1476	53	12	]	]	PUNCT
admet-1476	53	13	require	require	VERB
admet-1476	53	14	either	either	CCONJ
admet-1476	53	15	large	large	ADJ
admet-1476	53	16	quantities	quantity	NOUN
admet-1476	53	17	of	of	ADP
admet-1476	53	18	ds	ds	ADJ
admet-1476	53	19	or	or	CCONJ
admet-1476	53	20	drug	drug	NOUN
admet-1476	53	21	product	product	NOUN
admet-1476	53	22	(	(	PUNCT
admet-1476	53	23	dp	dp	NOUN
admet-1476	53	24	)	)	PUNCT
admet-1476	53	25	formulation	formulation	NOUN
admet-1476	53	26	for	for	ADP
admet-1476	53	27	the	the	DET
admet-1476	53	28	test	test	NOUN
admet-1476	53	29	.	.	PUNCT
admet-1476	54	1	this	this	DET
admet-1476	54	2	warrants	warrant	NOUN
admet-1476	54	3	for	for	ADP
admet-1476	54	4	a	a	DET
admet-1476	54	5	technique	technique	NOUN
admet-1476	54	6	to	to	PART
admet-1476	54	7	reliably	reliably	ADV
admet-1476	54	8	predict	predict	VERB
admet-1476	54	9	the	the	DET
admet-1476	54	10	food	food	NOUN
admet-1476	54	11	effect	effect	NOUN
admet-1476	54	12	using	use	VERB
admet-1476	54	13	a	a	DET
admet-1476	54	14	small	small	ADJ
admet-1476	54	15	quantity	quantity	NOUN
admet-1476	54	16	of	of	ADP
admet-1476	54	17	ds	ds	VERB
admet-1476	54	18	and	and	CCONJ
admet-1476	54	19	provides	provide	VERB
admet-1476	54	20	a	a	DET
admet-1476	54	21	middle	middle	ADJ
admet-1476	54	22	ground	ground	NOUN
admet-1476	54	23	between	between	ADP
admet-1476	54	24	physicochemical	physicochemical	ADJ
admet-1476	54	25	throughput	throughput	NOUN
admet-1476	54	26	screening	screening	NOUN
admet-1476	54	27	and	and	CCONJ
admet-1476	54	28	a	a	DET
admet-1476	54	29	final	final	ADJ
admet-1476	54	30	product	product	NOUN
admet-1476	54	31	testing	testing	NOUN
admet-1476	54	32	.	.	PUNCT
admet-1476	55	1	the	the	DET
admet-1476	55	2	solubility	solubility	NOUN
admet-1476	55	3	difference	difference	NOUN
admet-1476	55	4	between	between	ADP
admet-1476	55	5	fasted	fast	VERB
admet-1476	55	6	state	state	NOUN
admet-1476	55	7	simulated	simulate	VERB
admet-1476	55	8	intestinal	intestinal	ADJ
admet-1476	55	9	fluid	fluid	NOUN
admet-1476	55	10	(	(	PUNCT
admet-1476	55	11	fassif	fassif	NOUN
admet-1476	55	12	)	)	PUNCT
admet-1476	55	13	and	and	CCONJ
admet-1476	55	14	fed	feed	VERB
admet-1476	55	15	state	state	NOUN
admet-1476	55	16	simulated	simulate	VERB
admet-1476	55	17	intestinal	intestinal	ADJ
admet-1476	55	18	fluid	fluid	NOUN
admet-1476	55	19	(	(	PUNCT
admet-1476	55	20	fessif	fessif	NOUN
admet-1476	55	21	)	)	PUNCT
admet-1476	55	22	,	,	PUNCT
admet-1476	55	23	may	may	AUX
admet-1476	55	24	provide	provide	VERB
admet-1476	55	25	an	an	DET
admet-1476	55	26	initial	initial	ADJ
admet-1476	55	27	indication	indication	NOUN
admet-1476	55	28	about	about	ADP
admet-1476	55	29	the	the	DET
admet-1476	55	30	probable	probable	ADJ
admet-1476	55	31	food	food	NOUN
admet-1476	55	32	effect	effect	NOUN
admet-1476	55	33	,	,	PUNCT
admet-1476	55	34	but	but	CCONJ
admet-1476	55	35	as	as	SCONJ
admet-1476	55	36	mentioned	mention	VERB
admet-1476	55	37	above	above	ADV
admet-1476	55	38	,	,	PUNCT
admet-1476	55	39	an	an	DET
admet-1476	55	40	increase	increase	NOUN
admet-1476	55	41	in	in	ADP
admet-1476	55	42	drug	drug	NOUN
admet-1476	55	43	solubility	solubility	NOUN
admet-1476	55	44	in	in	ADP
admet-1476	55	45	fessif	fessif	NOUN
admet-1476	55	46	medium	medium	NOUN
admet-1476	55	47	may	may	AUX
admet-1476	55	48	not	not	PART
admet-1476	55	49	always	always	ADV
admet-1476	55	50	results	result	VERB
admet-1476	55	51	in	in	ADP
admet-1476	55	52	an	an	DET
admet-1476	55	53	increase	increase	NOUN
admet-1476	55	54	in	in	ADP
admet-1476	55	55	oral	oral	ADJ
admet-1476	55	56	absorption	absorption	NOUN
admet-1476	55	57	.	.	PUNCT
admet-1476	56	1	therefore	therefore	ADV
admet-1476	56	2	,	,	PUNCT
admet-1476	56	3	food	food	NOUN
admet-1476	56	4	effect	effect	NOUN
admet-1476	56	5	prediction	prediction	NOUN
admet-1476	56	6	based	base	VERB
admet-1476	56	7	on	on	ADP
admet-1476	56	8	solubility	solubility	NOUN
admet-1476	56	9	in	in	ADP
admet-1476	56	10	biorelevant	biorelevant	ADJ
admet-1476	56	11	media	medium	NOUN
admet-1476	56	12	may	may	AUX
admet-1476	56	13	be	be	AUX
admet-1476	56	14	misleading	misleading	ADJ
admet-1476	56	15	.	.	PUNCT
admet-1476	57	1	in	in	ADP
admet-1476	57	2	the	the	DET
admet-1476	57	3	fed	fed	PROPN
admet-1476	57	4	state	state	NOUN
admet-1476	57	5	,	,	PUNCT
admet-1476	57	6	the	the	DET
admet-1476	57	7	micelles	micelle	NOUN
admet-1476	57	8	and	and	CCONJ
admet-1476	57	9	colloidal	colloidal	NOUN
admet-1476	57	10	species	specie	NOUN
admet-1476	57	11	formed	form	VERB
admet-1476	57	12	by	by	ADP
admet-1476	57	13	bile	bile	NOUN
admet-1476	57	14	salts	salt	NOUN
admet-1476	57	15	and	and	CCONJ
admet-1476	57	16	lecithin	lecithin	NOUN
admet-1476	57	17	may	may	AUX
admet-1476	57	18	help	help	VERB
admet-1476	57	19	in	in	ADP
admet-1476	57	20	solubilization	solubilization	NOUN
admet-1476	57	21	of	of	ADP
admet-1476	57	22	insoluble	insoluble	ADJ
admet-1476	57	23	drugs	drug	NOUN
admet-1476	57	24	.	.	PUNCT
admet-1476	58	1	the	the	DET
admet-1476	58	2	drug	drug	NOUN
admet-1476	58	3	molecules	molecule	NOUN
admet-1476	58	4	may	may	AUX
admet-1476	58	5	form	form	VERB
admet-1476	58	6	a	a	DET
admet-1476	58	7	complex	complex	NOUN
admet-1476	58	8	with	with	ADP
admet-1476	58	9	bile	bile	NOUN
admet-1476	58	10	salts	salt	NOUN
admet-1476	58	11	or	or	CCONJ
admet-1476	58	12	might	might	AUX
admet-1476	58	13	get	get	VERB
admet-1476	58	14	“	"	PUNCT
admet-1476	58	15	entrapped	entrap	VERB
admet-1476	58	16	”	"	PUNCT
admet-1476	58	17	into	into	ADP
admet-1476	58	18	the	the	DET
admet-1476	58	19	micellar	micellar	ADJ
admet-1476	58	20	core	core	NOUN
admet-1476	58	21	.	.	PUNCT
admet-1476	59	1	as	as	SCONJ
admet-1476	59	2	only	only	ADV
admet-1476	59	3	the	the	DET
admet-1476	59	4	free	free	ADJ
admet-1476	59	5	drug	drug	NOUN
admet-1476	59	6	molecules	molecule	NOUN
admet-1476	59	7	in	in	ADP
admet-1476	59	8	solution	solution	NOUN
admet-1476	59	9	(	(	PUNCT
admet-1476	59	10	unbound	unbound	NOUN
admet-1476	59	11	form	form	NOUN
admet-1476	59	12	)	)	PUNCT
admet-1476	59	13	of	of	ADP
admet-1476	59	14	the	the	DET
admet-1476	59	15	drug	drug	NOUN
admet-1476	59	16	is	be	AUX
admet-1476	59	17	available	available	ADJ
admet-1476	59	18	for	for	ADP
admet-1476	59	19	the	the	DET
admet-1476	59	20	absorption	absorption	NOUN
admet-1476	59	21	through	through	ADP
admet-1476	59	22	the	the	DET
admet-1476	59	23	epithelial	epithelial	ADJ
admet-1476	59	24	membrane	membrane	NOUN
admet-1476	59	25	,	,	PUNCT
admet-1476	59	26	the	the	DET
admet-1476	59	27	equilibrium	equilibrium	NOUN
admet-1476	59	28	solubility	solubility	NOUN
admet-1476	59	29	data	datum	NOUN
admet-1476	59	30	and	and	CCONJ
admet-1476	59	31	the	the	DET
admet-1476	59	32	total	total	ADJ
admet-1476	59	33	drug	drug	NOUN
admet-1476	59	34	dissolved	dissolve	VERB
admet-1476	59	35	may	may	AUX
admet-1476	59	36	not	not	PART
admet-1476	59	37	reliably	reliably	ADV
admet-1476	59	38	predict	predict	VERB
admet-1476	59	39	the	the	DET
admet-1476	59	40	food	food	NOUN
admet-1476	59	41	effect	effect	NOUN
admet-1476	59	42	.	.	PUNCT
admet-1476	60	1	in	in	ADP
admet-1476	60	2	the	the	DET
admet-1476	60	3	present	present	ADJ
admet-1476	60	4	research	research	NOUN
admet-1476	60	5	,	,	PUNCT
admet-1476	60	6	we	we	PRON
admet-1476	60	7	hypothesized	hypothesize	VERB
admet-1476	60	8	that	that	SCONJ
admet-1476	60	9	in	in	ADP
admet-1476	60	10	addition	addition	NOUN
admet-1476	60	11	to	to	ADP
admet-1476	60	12	the	the	DET
admet-1476	60	13	drug	drug	NOUN
admet-1476	60	14	dissolution	dissolution	NOUN
admet-1476	60	15	in	in	ADP
admet-1476	60	16	biorelevant	biorelevant	ADJ
admet-1476	60	17	media	medium	NOUN
admet-1476	60	18	,	,	PUNCT
admet-1476	60	19	the	the	DET
admet-1476	60	20	evaluation	evaluation	NOUN
admet-1476	60	21	of	of	ADP
admet-1476	60	22	the	the	DET
admet-1476	60	23	diffusion	diffusion	NOUN
admet-1476	60	24	flux	flux	NOUN
admet-1476	60	25	(	(	PUNCT
admet-1476	60	26	membrane	membrane	NOUN
admet-1476	60	27	transport	transport	NOUN
admet-1476	60	28	rate	rate	NOUN
admet-1476	60	29	across	across	ADP
admet-1476	60	30	artificial	artificial	ADJ
admet-1476	60	31	,	,	PUNCT
admet-1476	60	32	lipid	lipid	NOUN
admet-1476	60	33	coated	coat	VERB
admet-1476	60	34	membrane	membrane	NOUN
admet-1476	60	35	,	,	PUNCT
admet-1476	60	36	using	use	VERB
admet-1476	60	37	side	side	NOUN
admet-1476	60	38	-	-	PUNCT
admet-1476	60	39	by	by	ADP
admet-1476	60	40	-	-	PUNCT
admet-1476	60	41	side	side	NOUN
admet-1476	60	42	diffusion	diffusion	NOUN
admet-1476	60	43	cells	cell	NOUN
admet-1476	60	44	)	)	PUNCT
admet-1476	60	45	of	of	ADP
admet-1476	60	46	a	a	DET
admet-1476	60	47	drug	drug	NOUN
admet-1476	60	48	in	in	ADP
admet-1476	60	49	solution	solution	NOUN
admet-1476	60	50	,	,	PUNCT
admet-1476	60	51	where	where	SCONJ
admet-1476	60	52	only	only	ADV
admet-1476	60	53	the	the	DET
admet-1476	60	54	unbound	unbound	NOUN
admet-1476	60	55	drug	drug	NOUN
admet-1476	60	56	crosses	cross	VERB
admet-1476	60	57	the	the	DET
admet-1476	60	58	membrane	membrane	NOUN
admet-1476	60	59	,	,	PUNCT
admet-1476	60	60	is	be	AUX
admet-1476	60	61	more	more	ADV
admet-1476	60	62	reliable	reliable	ADJ
admet-1476	60	63	way	way	NOUN
admet-1476	60	64	to	to	PART
admet-1476	60	65	predict	predict	VERB
admet-1476	60	66	the	the	DET
admet-1476	60	67	food	food	NOUN
admet-1476	60	68	effect	effect	NOUN
admet-1476	60	69	(	(	PUNCT
admet-1476	60	70	fe	fe	NOUN
admet-1476	60	71	)	)	PUNCT
admet-1476	60	72	.	.	PUNCT
admet-1476	61	1	to	to	PART
admet-1476	61	2	test	test	VERB
admet-1476	61	3	the	the	DET
admet-1476	61	4	hypothesis	hypothesis	NOUN
admet-1476	61	5	,	,	PUNCT
admet-1476	61	6	we	we	PRON
admet-1476	61	7	utilized	utilize	VERB
admet-1476	61	8	eleven	eleven	NUM
admet-1476	61	9	model	model	NOUN
admet-1476	61	10	compounds	compound	NOUN
admet-1476	61	11	belonging	belong	VERB
admet-1476	61	12	to	to	ADP
admet-1476	61	13	biopharmaceutics	biopharmaceutics	NOUN
admet-1476	61	14	classification	classification	NOUN
admet-1476	61	15	system	system	NOUN
admet-1476	61	16	(	(	PUNCT
admet-1476	61	17	bcs	bc	NOUN
admet-1476	61	18	)	)	PUNCT
admet-1476	61	19	i	i	NOUN
admet-1476	61	20	iv	iv	VERB
admet-1476	61	21	categories	category	NOUN
admet-1476	61	22	.	.	PUNCT
admet-1476	62	1	material	material	NOUN
admet-1476	62	2	and	and	CCONJ
admet-1476	62	3	methods	method	NOUN
admet-1476	62	4	materials	material	NOUN
admet-1476	62	5	amiodarone	amiodarone	NOUN
admet-1476	62	6	hydrochloride	hydrochloride	NOUN
admet-1476	62	7	,	,	PUNCT
admet-1476	62	8	celecoxib	celecoxib	NOUN
admet-1476	62	9	,	,	PUNCT
admet-1476	62	10	clopidogrel	clopidogrel	NOUN
admet-1476	62	11	bisulfate	bisulfate	NOUN
admet-1476	62	12	,	,	PUNCT
admet-1476	62	13	danazol	danazol	ADJ
admet-1476	62	14	,	,	PUNCT
admet-1476	62	15	fluoxetine	fluoxetine	ADJ
admet-1476	62	16	hydrochloride	hydrochloride	NOUN
admet-1476	62	17	,	,	PUNCT
admet-1476	62	18	furosemide	furosemide	ADV
admet-1476	62	19	,	,	PUNCT
admet-1476	62	20	nefazodone	nefazodone	NOUN
admet-1476	62	21	hydrochloride	hydrochloride	NOUN
admet-1476	62	22	,	,	PUNCT
admet-1476	62	23	nifedipine	nifedipine	NOUN
admet-1476	62	24	,	,	PUNCT
admet-1476	62	25	zidovudine	zidovudine	PROPN
admet-1476	62	26	and	and	CCONJ
admet-1476	62	27	isoniazid	isoniazid	NOUN
admet-1476	62	28	were	be	AUX
admet-1476	62	29	purchased	purchase	VERB
admet-1476	62	30	from	from	ADP
admet-1476	62	31	sigma	sigma	PROPN
admet-1476	62	32	aldrich	aldrich	PROPN
admet-1476	62	33	inc	inc	PROPN
admet-1476	62	34	.	.	PROPN
admet-1476	62	35	(	(	PUNCT
admet-1476	62	36	milwaukee	milwaukee	PROPN
admet-1476	62	37	,	,	PUNCT
admet-1476	62	38	wi	wi	PROPN
admet-1476	62	39	,	,	PUNCT
admet-1476	62	40	usa	usa	PROPN
admet-1476	62	41	)	)	PUNCT
admet-1476	62	42	.	.	PUNCT
admet-1476	63	1	griseofulvin	griseofulvin	NOUN
admet-1476	63	2	was	be	AUX
admet-1476	63	3	provided	provide	VERB
admet-1476	63	4	by	by	ADP
admet-1476	63	5	pion	pion	NOUN
admet-1476	63	6	.	.	PUNCT
admet-1476	64	1	the	the	DET
admet-1476	64	2	gastrointestinal	gastrointestinal	ADJ
admet-1476	64	3	tract	tract	NOUN
admet-1476	64	4	lipid	lipid	NOUN
admet-1476	64	5	(	(	PUNCT
admet-1476	64	6	git-0	git-0	NUM
admet-1476	64	7	pn	pn	PROPN
admet-1476	64	8	110669	110669	NUM
admet-1476	64	9	)	)	PUNCT
admet-1476	64	10	,	,	PUNCT
admet-1476	64	11	the	the	DET
admet-1476	64	12	acceptor	acceptor	NOUN
admet-1476	64	13	sink	sink	NOUN
admet-1476	64	14	-	-	PUNCT
admet-1476	64	15	buffer	buffer	NOUN
admet-1476	64	16	(	(	PUNCT
admet-1476	64	17	asb	asb	PROPN
admet-1476	64	18	pn	pn	PROPN
admet-1476	64	19	110139	110139	NUM
admet-1476	64	20	)	)	PUNCT
admet-1476	64	21	and	and	CCONJ
admet-1476	64	22	the	the	DET
admet-1476	64	23	pvdf	pvdf	PROPN
admet-1476	64	24	(	(	PUNCT
admet-1476	64	25	polyvinylidene	polyvinylidene	NOUN
admet-1476	64	26	difluoride	difluoride	NOUN
admet-1476	64	27	)	)	PUNCT
admet-1476	64	28	filter	filter	NOUN
admet-1476	64	29	support	support	NOUN
admet-1476	64	30	(	(	PUNCT
admet-1476	64	31	pn	pn	NOUN
admet-1476	64	32	120875	120875	NUM
admet-1476	64	33	)	)	PUNCT
admet-1476	64	34	were	be	AUX
admet-1476	64	35	purchased	purchase	VERB
admet-1476	64	36	from	from	ADP
admet-1476	64	37	pion	pion	PROPN
admet-1476	64	38	inc	inc	PROPN
admet-1476	64	39	.	.	PROPN
admet-1476	65	1	(	(	PUNCT
admet-1476	65	2	billerica	billerica	PROPN
admet-1476	65	3	,	,	PUNCT
admet-1476	65	4	ma	ma	PROPN
admet-1476	65	5	,	,	PUNCT
admet-1476	65	6	usa	usa	PROPN
admet-1476	65	7	)	)	PUNCT
admet-1476	65	8	.	.	PUNCT
admet-1476	66	1	fassif	fassif	NOUN
admet-1476	66	2	buffer	buffer	VERB
admet-1476	66	3	concentrate	concentrate	NOUN
admet-1476	66	4	,	,	PUNCT
admet-1476	66	5	fessif	fessif	NOUN
admet-1476	66	6	buffer	buffer	VERB
admet-1476	66	7	concentrate	concentrate	NOUN
admet-1476	66	8	and	and	CCONJ
admet-1476	66	9	the	the	DET
admet-1476	66	10	simulated	simulated	ADJ
admet-1476	66	11	intestinal	intestinal	ADJ
admet-1476	66	12	powder	powder	NOUN
admet-1476	66	13	version	version	NOUN
admet-1476	66	14	i	i	PRON
admet-1476	66	15	fassif	fassif	VERB
admet-1476	66	16	/	/	SYM
admet-1476	66	17	fessif	fessif	ADJ
admet-1476	66	18	/	/	SYM
admet-1476	66	19	fassgf	fassgf	NOUN
admet-1476	66	20	,	,	PUNCT
admet-1476	66	21	were	be	AUX
admet-1476	66	22	purchased	purchase	VERB
admet-1476	66	23	from	from	ADP
admet-1476	66	24	biorelevant.com	biorelevant.com	X
admet-1476	66	25	(	(	PUNCT
admet-1476	66	26	london	london	PROPN
admet-1476	66	27	u.k	u.k	PROPN
admet-1476	66	28	.	.	PROPN
admet-1476	66	29	)	)	PUNCT
admet-1476	66	30	.	.	PUNCT
admet-1476	67	1	dmso	dmso	NOUN
admet-1476	67	2	(	(	PUNCT
admet-1476	67	3	dimethyl	dimethyl	NOUN
admet-1476	67	4	sulfoxide	sulfoxide	NOUN
admet-1476	67	5	)	)	PUNCT
admet-1476	67	6	and	and	CCONJ
admet-1476	67	7	methanol	methanol	NOUN
admet-1476	67	8	(	(	PUNCT
admet-1476	67	9	hplc	hplc	NOUN
admet-1476	67	10	plus	plus	CCONJ
admet-1476	67	11	grade	grade	NOUN
admet-1476	67	12	)	)	PUNCT
admet-1476	67	13	used	use	VERB
admet-1476	67	14	to	to	PART
admet-1476	67	15	prepare	prepare	VERB
admet-1476	67	16	the	the	DET
admet-1476	67	17	stock	stock	NOUN
admet-1476	67	18	solution	solution	NOUN
admet-1476	67	19	for	for	ADP
admet-1476	67	20	standards	standard	NOUN
admet-1476	67	21	were	be	AUX
admet-1476	67	22	purchased	purchase	VERB
admet-1476	67	23	from	from	ADP
admet-1476	67	24	sigma	sigma	PROPN
admet-1476	67	25	aldrich	aldrich	PROPN
admet-1476	67	26	(	(	PUNCT
admet-1476	67	27	milwaukee	milwaukee	PROPN
admet-1476	67	28	,	,	PUNCT
admet-1476	67	29	wi	wi	PROPN
admet-1476	67	30	,	,	PUNCT
admet-1476	67	31	usa	usa	PROPN
admet-1476	67	32	)	)	PUNCT
admet-1476	67	33	.	.	PUNCT
admet-1476	68	1	media	medium	NOUN
admet-1476	68	2	preparation	preparation	NOUN
admet-1476	68	3	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	PROPN
admet-1476	68	4	c.	c.	PROPN
admet-1476	68	5	jankovsky	jankovsky	PROPN
admet-1476	68	6	et	et	PROPN
admet-1476	68	7	al	al	PROPN
admet-1476	68	8	.	.	PROPN
admet-1476	68	9	admet	admet	PROPN
admet-1476	68	10	&	&	CCONJ
admet-1476	68	11	dmpk	dmpk	PROPN
admet-1476	68	12	10(4	10(4	NUM
admet-1476	68	13	)	)	PUNCT
admet-1476	68	14	(	(	PUNCT
admet-1476	68	15	2022	2022	NUM
admet-1476	68	16	)	)	PUNCT
admet-1476	68	17	299	299	NUM
admet-1476	68	18	-	-	SYM
admet-1476	68	19	314	314	NUM
admet-1476	68	20	302	302	NUM
admet-1476	68	21	dissolution	dissolution	NOUN
admet-1476	68	22	/	/	SYM
admet-1476	68	23	flux	flux	NOUN
admet-1476	68	24	tests	test	NOUN
admet-1476	68	25	were	be	AUX
admet-1476	68	26	performed	perform	VERB
admet-1476	68	27	using	use	VERB
admet-1476	68	28	the	the	DET
admet-1476	68	29	fassif	fassif	NOUN
admet-1476	68	30	,	,	PUNCT
admet-1476	68	31	fessif	fessif	AUX
admet-1476	68	32	version	version	NOUN
admet-1476	68	33	1	1	NUM
admet-1476	68	34	to	to	PART
admet-1476	68	35	simulate	simulate	VERB
admet-1476	68	36	the	the	DET
admet-1476	68	37	fasted	fast	VERB
admet-1476	68	38	state	state	NOUN
admet-1476	68	39	and	and	CCONJ
admet-1476	68	40	fed	feed	VERB
admet-1476	68	41	state	state	NOUN
admet-1476	68	42	intestinal	intestinal	ADJ
admet-1476	68	43	fluids	fluid	NOUN
admet-1476	68	44	(	(	PUNCT
admet-1476	68	45	table-1	table-1	PROPN
admet-1476	68	46	for	for	ADP
admet-1476	68	47	media	media	NOUN
admet-1476	68	48	composition	composition	NOUN
admet-1476	68	49	)	)	PUNCT
admet-1476	68	50	.	.	PUNCT
admet-1476	69	1	fassif	fassif	NOUN
admet-1476	69	2	and	and	CCONJ
admet-1476	69	3	fessif	fessif	NOUN
admet-1476	69	4	were	be	AUX
admet-1476	69	5	prepared	prepare	VERB
admet-1476	69	6	using	use	VERB
admet-1476	69	7	the	the	DET
admet-1476	69	8	buffer	buffer	NOUN
admet-1476	69	9	concentrate	concentrate	NOUN
admet-1476	69	10	method	method	NOUN
admet-1476	69	11	with	with	ADP
admet-1476	69	12	fasgf	fasgf	NOUN
admet-1476	69	13	/	/	SYM
admet-1476	69	14	fassif	fassif	NOUN
admet-1476	69	15	/	/	SYM
admet-1476	69	16	fessif	fessif	NOUN
admet-1476	69	17	powder	powder	NOUN
admet-1476	69	18	as	as	SCONJ
admet-1476	69	19	described	describe	VERB
admet-1476	69	20	in	in	ADP
admet-1476	69	21	biorelevant	biorelevant	ADJ
admet-1476	69	22	media	medium	NOUN
admet-1476	69	23	preparation	preparation	NOUN
admet-1476	69	24	tool	tool	NOUN
admet-1476	69	25	on	on	ADP
admet-1476	69	26	their	their	PRON
admet-1476	69	27	website	website	NOUN
admet-1476	69	28	(	(	PUNCT
admet-1476	69	29	biorelevant.com	biorelevant.com	X
admet-1476	69	30	)	)	PUNCT
admet-1476	69	31	.	.	PUNCT
admet-1476	70	1	table-1	table-1	NUM
admet-1476	70	2	summarizes	summarize	VERB
admet-1476	70	3	the	the	DET
admet-1476	70	4	composition	composition	NOUN
admet-1476	70	5	of	of	ADP
admet-1476	70	6	the	the	DET
admet-1476	70	7	intestinal	intestinal	ADJ
admet-1476	70	8	media	medium	NOUN
admet-1476	70	9	used	use	VERB
admet-1476	70	10	in	in	ADP
admet-1476	70	11	this	this	DET
admet-1476	70	12	study	study	NOUN
admet-1476	70	13	.	.	PUNCT
admet-1476	71	1	table	table	NOUN
admet-1476	71	2	1	1	NUM
admet-1476	71	3	.	.	PUNCT
admet-1476	72	1	composition	composition	NOUN
admet-1476	72	2	of	of	ADP
admet-1476	72	3	the	the	DET
admet-1476	72	4	biorelevant	biorelevant	ADJ
admet-1476	72	5	media	medium	NOUN
admet-1476	72	6	level	level	NOUN
admet-1476	72	7	i	i	PRON
admet-1476	73	1	[	[	X
admet-1476	73	2	16	16	NUM
admet-1476	73	3	]	]	PUNCT
admet-1476	73	4	fassif	fassif	VERB
admet-1476	73	5	fessif	fessif	PROPN
admet-1476	73	6	sodium	sodium	PROPN
admet-1476	73	7	taurocholate	taurocholate	NOUN
admet-1476	73	8	(	(	PUNCT
admet-1476	73	9	mm	mm	NOUN
admet-1476	73	10	)	)	PUNCT
admet-1476	73	11	3	3	NUM
admet-1476	73	12	15	15	NUM
admet-1476	73	13	lecithin	lecithin	NOUN
admet-1476	73	14	(	(	PUNCT
admet-1476	73	15	mm	mm	NOUN
admet-1476	73	16	)	)	PUNCT
admet-1476	73	17	0.75	0.75	NUM
admet-1476	73	18	3.75	3.75	NUM
admet-1476	73	19	monobasic	monobasic	NOUN
admet-1476	73	20	sodium	sodium	NOUN
admet-1476	73	21	phosphate	phosphate	NOUN
admet-1476	73	22	(	(	PUNCT
admet-1476	73	23	mm	mm	NOUN
admet-1476	73	24	)	)	PUNCT
admet-1476	73	25	28.36	28.36	NUM
admet-1476	73	26	glacial	glacial	ADJ
admet-1476	73	27	acetic	acetic	ADJ
admet-1476	73	28	acid	acid	NOUN
admet-1476	73	29	(	(	PUNCT
admet-1476	73	30	mm	mm	NOUN
admet-1476	73	31	)	)	PUNCT
admet-1476	73	32	144.00	144.00	NUM
admet-1476	73	33	sodium	sodium	NOUN
admet-1476	73	34	hydroxide	hydroxide	NOUN
admet-1476	73	35	(	(	PUNCT
admet-1476	73	36	mm	mm	NOUN
admet-1476	73	37	)	)	PUNCT
admet-1476	73	38	~13.8	~13.8	NOUN
admet-1476	73	39	101	101	NUM
admet-1476	73	40	sodium	sodium	NOUN
admet-1476	73	41	chloride	chloride	NOUN
admet-1476	73	42	(	(	PUNCT
admet-1476	73	43	mm	mm	NOUN
admet-1476	73	44	)	)	PUNCT
admet-1476	73	45	106	106	NUM
admet-1476	73	46	173	173	NUM
admet-1476	73	47	characteristic	characteristic	ADJ
admet-1476	73	48	ph	ph	NOUN
admet-1476	73	49	6.5	6.5	NUM
admet-1476	73	50	5	5	NUM
admet-1476	73	51	osmolality	osmolality	NOUN
admet-1476	73	52	(	(	PUNCT
admet-1476	73	53	mosm	mosm	NOUN
admet-1476	73	54	kg-1	kg-1	NOUN
admet-1476	73	55	)	)	PUNCT
admet-1476	73	56	270	270	NUM
admet-1476	73	57	±	±	NUM
admet-1476	73	58	10	10	NUM
admet-1476	73	59	635	635	NUM
admet-1476	73	60	±	±	NUM
admet-1476	73	61	10	10	NUM
admet-1476	73	62	buffer	buffer	NOUN
admet-1476	73	63	capacity	capacity	NOUN
admet-1476	73	64	(	(	PUNCT
admet-1476	73	65	mmol	mmol	NOUN
admet-1476	73	66	l-1	l-1	PROPN
admet-1476	73	67	dph-1	dph-1	PROPN
admet-1476	73	68	)	)	PUNCT
admet-1476	73	69	12	12	NUM
admet-1476	73	70	76	76	NUM
admet-1476	73	71	±	±	NUM
admet-1476	73	72	2	2	NUM
admet-1476	73	73	methods	method	NOUN
admet-1476	73	74	dissolution	dissolution	NOUN
admet-1476	73	75	/	/	SYM
admet-1476	73	76	flux	flux	NOUN
admet-1476	73	77	tests	test	NOUN
admet-1476	73	78	were	be	AUX
admet-1476	73	79	performed	perform	VERB
admet-1476	73	80	using	use	VERB
admet-1476	73	81	a	a	DET
admet-1476	73	82	μflux	μflux	NOUN
admet-1476	73	83	apparatus	apparatus	NOUN
admet-1476	73	84	(	(	PUNCT
admet-1476	73	85	pion	pion	PROPN
admet-1476	73	86	inc	inc	PROPN
admet-1476	73	87	.	.	PROPN
admet-1476	73	88	,	,	PUNCT
admet-1476	73	89	billerica	billerica	PROPN
admet-1476	73	90	,	,	PUNCT
admet-1476	73	91	ma	ma	PROPN
admet-1476	73	92	,	,	PUNCT
admet-1476	73	93	usa	usa	PROPN
admet-1476	73	94	)	)	PUNCT
admet-1476	73	95	with	with	ADP
admet-1476	73	96	4	4	NUM
admet-1476	73	97	sideby	sideby	ADJ
admet-1476	73	98	-	-	PUNCT
admet-1476	73	99	side	side	NOUN
admet-1476	73	100	donor	donor	NOUN
admet-1476	73	101	-	-	PUNCT
admet-1476	73	102	receiver	receiver	NOUN
admet-1476	73	103	chambers	chamber	NOUN
admet-1476	73	104	separated	separate	VERB
admet-1476	73	105	by	by	ADP
admet-1476	73	106	a	a	DET
admet-1476	73	107	lipophilic	lipophilic	ADJ
admet-1476	73	108	barrier	barrier	NOUN
admet-1476	73	109	.	.	PUNCT
admet-1476	74	1	prior	prior	ADV
admet-1476	74	2	to	to	ADP
admet-1476	74	3	the	the	DET
admet-1476	74	4	assay	assay	NOUN
admet-1476	74	5	,	,	PUNCT
admet-1476	74	6	the	the	DET
admet-1476	74	7	artificial	artificial	ADJ
admet-1476	74	8	gitmimicking	gitmimicking	NOUN
admet-1476	74	9	membrane	membrane	NOUN
admet-1476	74	10	was	be	AUX
admet-1476	74	11	prepared	prepare	VERB
admet-1476	74	12	by	by	ADP
admet-1476	74	13	impregnating	impregnate	VERB
admet-1476	74	14	a	a	DET
admet-1476	74	15	pvdf	pvdf	PROPN
admet-1476	74	16	filter	filter	NOUN
admet-1476	74	17	support	support	NOUN
admet-1476	74	18	material	material	NOUN
admet-1476	74	19	(	(	PUNCT
admet-1476	74	20	polyvinylidenfluoride	polyvinylidenfluoride	ADJ
admet-1476	74	21	,	,	PUNCT
admet-1476	74	22	1.54	1.54	NUM
admet-1476	74	23	cm2	cm2	PROPN
admet-1476	74	24	open	open	ADJ
admet-1476	74	25	area	area	NOUN
admet-1476	74	26	,	,	PUNCT
admet-1476	74	27	0.45	0.45	NUM
admet-1476	74	28	μm	μm	NOUN
admet-1476	74	29	pore	pore	ADJ
admet-1476	74	30	size	size	NOUN
admet-1476	74	31	,	,	PUNCT
admet-1476	74	32	120	120	NUM
admet-1476	74	33	μm	μm	NUM
admet-1476	74	34	thickness	thickness	NOUN
admet-1476	74	35	,	,	PUNCT
admet-1476	74	36	70	70	NUM
admet-1476	74	37	%	%	NOUN
admet-1476	74	38	nominal	nominal	ADJ
admet-1476	74	39	porosity	porosity	NOUN
admet-1476	74	40	)	)	PUNCT
admet-1476	74	41	with	with	ADP
admet-1476	74	42	25	25	NUM
admet-1476	74	43	μl	μl	NOUN
admet-1476	74	44	of	of	ADP
admet-1476	74	45	20	20	NUM
admet-1476	74	46	%	%	NOUN
admet-1476	74	47	lecithin	lecithin	NOUN
admet-1476	74	48	in	in	ADP
admet-1476	74	49	dodecane	dodecane	NOUN
admet-1476	74	50	lipid	lipid	NOUN
admet-1476	74	51	solution	solution	NOUN
admet-1476	74	52	(	(	PUNCT
admet-1476	74	53	git	git	NOUN
admet-1476	74	54	lipid	lipid	NOUN
admet-1476	74	55	,	,	PUNCT
admet-1476	74	56	pion	pion	PROPN
admet-1476	74	57	inc	inc	PROPN
admet-1476	74	58	.	.	PROPN
admet-1476	74	59	,	,	PUNCT
admet-1476	74	60	billerica	billerica	PROPN
admet-1476	74	61	,	,	PUNCT
admet-1476	74	62	ma	ma	PROPN
admet-1476	74	63	,	,	PUNCT
admet-1476	74	64	usa	usa	PROPN
admet-1476	74	65	)	)	PUNCT
admet-1476	74	66	.	.	PUNCT
admet-1476	75	1	the	the	DET
admet-1476	75	2	donor	donor	NOUN
admet-1476	75	3	chambers	chamber	NOUN
admet-1476	75	4	were	be	AUX
admet-1476	75	5	then	then	ADV
admet-1476	75	6	filled	fill	VERB
admet-1476	75	7	with	with	ADP
admet-1476	75	8	20	20	NUM
admet-1476	75	9	ml	ml	NOUN
admet-1476	75	10	of	of	ADP
admet-1476	75	11	biorelevant	biorelevant	ADJ
admet-1476	75	12	media	medium	NOUN
admet-1476	75	13	(	(	PUNCT
admet-1476	75	14	fassif	fassif	NOUN
admet-1476	75	15	or	or	CCONJ
admet-1476	75	16	fessif	fessif	ADJ
admet-1476	75	17	)	)	PUNCT
admet-1476	75	18	while	while	SCONJ
admet-1476	75	19	the	the	DET
admet-1476	75	20	receiver	receiver	ADJ
admet-1476	75	21	compartments	compartment	NOUN
admet-1476	75	22	were	be	AUX
admet-1476	75	23	filled	fill	VERB
admet-1476	75	24	with	with	ADP
admet-1476	75	25	20	20	NUM
admet-1476	75	26	ml	ml	NOUN
admet-1476	75	27	of	of	ADP
admet-1476	75	28	acceptor	acceptor	NOUN
admet-1476	75	29	sink	sink	NOUN
admet-1476	75	30	buffer	buffer	NOUN
admet-1476	75	31	(	(	PUNCT
admet-1476	75	32	asb	asb	PROPN
admet-1476	75	33	,	,	PUNCT
admet-1476	75	34	pion	pion	PROPN
admet-1476	75	35	inc	inc	PROPN
admet-1476	75	36	.	.	PROPN
admet-1476	75	37	,	,	PUNCT
admet-1476	75	38	billerica	billerica	PROPN
admet-1476	75	39	,	,	PUNCT
admet-1476	75	40	ma	ma	PROPN
admet-1476	75	41	,	,	PUNCT
admet-1476	75	42	usa	usa	PROPN
admet-1476	75	43	)	)	PUNCT
admet-1476	75	44	.	.	PUNCT
admet-1476	76	1	the	the	DET
admet-1476	76	2	asb	asb	PROPN
admet-1476	76	3	is	be	AUX
admet-1476	76	4	a	a	DET
admet-1476	76	5	hepes	hepe	NOUN
admet-1476	76	6	(	(	PUNCT
admet-1476	76	7	4-(2	4-(2	PROPN
admet-1476	76	8	-	-	PUNCT
admet-1476	76	9	hydroxyethyl)-1piperazineethanesulfonic	hydroxyethyl)-1piperazineethanesulfonic	ADJ
admet-1476	76	10	acid	acid	NOUN
admet-1476	76	11	)	)	PUNCT
admet-1476	76	12	based	base	VERB
admet-1476	76	13	ph	ph	NOUN
admet-1476	76	14	7.4	7.4	NUM
admet-1476	76	15	buffer	buffer	NOUN
admet-1476	76	16	containing	contain	VERB
admet-1476	76	17	chemical	chemical	ADJ
admet-1476	76	18	scavengers	scavenger	NOUN
admet-1476	76	19	(	(	PUNCT
admet-1476	76	20	surfactants	surfactant	NOUN
admet-1476	76	21	micelles	micelle	NOUN
admet-1476	76	22	)	)	PUNCT
admet-1476	76	23	that	that	PRON
admet-1476	76	24	allow	allow	VERB
admet-1476	76	25	to	to	PART
admet-1476	76	26	maintain	maintain	VERB
admet-1476	76	27	sink	sink	NOUN
admet-1476	76	28	conditions	condition	NOUN
admet-1476	76	29	during	during	ADP
admet-1476	76	30	the	the	DET
admet-1476	76	31	experiments	experiment	NOUN
admet-1476	76	32	.	.	PUNCT
admet-1476	77	1	the	the	DET
admet-1476	77	2	composition	composition	NOUN
admet-1476	77	3	of	of	ADP
admet-1476	77	4	the	the	DET
admet-1476	77	5	membrane	membrane	NOUN
admet-1476	77	6	and	and	CCONJ
admet-1476	77	7	the	the	DET
admet-1476	77	8	receiver	receiver	ADJ
admet-1476	77	9	solution	solution	NOUN
admet-1476	77	10	are	be	AUX
admet-1476	77	11	identical	identical	ADJ
admet-1476	77	12	to	to	ADP
admet-1476	77	13	the	the	DET
admet-1476	77	14	double	double	ADJ
admet-1476	77	15	-	-	PUNCT
admet-1476	77	16	sink	sink	NOUN
admet-1476	77	17	pampa	pampa	NOUN
admet-1476	77	18	model	model	NOUN
admet-1476	77	19	[	[	X
admet-1476	77	20	17	17	NUM
admet-1476	77	21	]	]	X
admet-1476	77	22	,	,	PUNCT
admet-1476	77	23	a	a	DET
admet-1476	77	24	non	non	ADJ
admet-1476	77	25	-	-	ADJ
admet-1476	77	26	cell	cell	NOUN
admet-1476	77	27	-	-	PUNCT
admet-1476	77	28	based	base	VERB
admet-1476	77	29	method	method	NOUN
admet-1476	77	30	predicting	predict	VERB
admet-1476	77	31	of	of	ADP
admet-1476	77	32	passive	passive	ADJ
admet-1476	77	33	transcellular	transcellular	ADJ
admet-1476	77	34	intestinal	intestinal	ADJ
admet-1476	77	35	absorption	absorption	NOUN
admet-1476	77	36	.	.	PUNCT
admet-1476	78	1	the	the	DET
admet-1476	78	2	temperature	temperature	NOUN
admet-1476	78	3	in	in	ADP
admet-1476	78	4	both	both	DET
admet-1476	78	5	chambers	chamber	NOUN
admet-1476	78	6	was	be	AUX
admet-1476	78	7	maintained	maintain	VERB
admet-1476	78	8	at	at	ADP
admet-1476	78	9	37	37	NUM
admet-1476	78	10	°	°	ADP
admet-1476	78	11	c	c	NOUN
admet-1476	78	12	and	and	CCONJ
admet-1476	78	13	the	the	DET
admet-1476	78	14	media	medium	NOUN
admet-1476	78	15	were	be	AUX
admet-1476	78	16	stirred	stir	VERB
admet-1476	78	17	at	at	ADP
admet-1476	78	18	100	100	NUM
admet-1476	78	19	rpm	rpm	NOUN
admet-1476	78	20	.	.	PUNCT
admet-1476	79	1	model	model	NOUN
admet-1476	79	2	compounds	compound	NOUN
admet-1476	79	3	were	be	AUX
admet-1476	79	4	added	add	VERB
admet-1476	79	5	at	at	ADP
admet-1476	79	6	the	the	DET
admet-1476	79	7	start	start	NOUN
admet-1476	79	8	of	of	ADP
admet-1476	79	9	the	the	DET
admet-1476	79	10	experiment	experiment	NOUN
admet-1476	79	11	in	in	ADP
admet-1476	79	12	the	the	DET
admet-1476	79	13	donor	donor	NOUN
admet-1476	79	14	chambers	chamber	NOUN
admet-1476	79	15	as	as	ADP
admet-1476	79	16	unformulated	unformulate	VERB
admet-1476	79	17	powder	powder	NOUN
admet-1476	79	18	at	at	ADP
admet-1476	79	19	a	a	DET
admet-1476	79	20	solid	solid	ADJ
admet-1476	79	21	load	load	NOUN
admet-1476	79	22	equivalent	equivalent	ADJ
admet-1476	79	23	to	to	ADP
admet-1476	79	24	the	the	DET
admet-1476	79	25	lowest	low	ADJ
admet-1476	79	26	marketed	market	VERB
admet-1476	79	27	dose	dose	NOUN
admet-1476	79	28	normalized	normalize	VERB
admet-1476	79	29	to	to	ADP
admet-1476	79	30	250	250	NUM
admet-1476	79	31	ml	ml	ADP
admet-1476	79	32	stomach	stomach	NOUN
admet-1476	79	33	volume	volume	NOUN
admet-1476	79	34	.	.	PUNCT
admet-1476	80	1	in	in	ADP
admet-1476	80	2	some	some	DET
admet-1476	80	3	cases	case	NOUN
admet-1476	80	4	,	,	PUNCT
admet-1476	80	5	to	to	PART
admet-1476	80	6	counter	counter	VERB
admet-1476	80	7	for	for	ADP
admet-1476	80	8	experimental	experimental	ADJ
admet-1476	80	9	limitation	limitation	NOUN
admet-1476	80	10	due	due	ADP
admet-1476	80	11	to	to	ADP
admet-1476	80	12	low	low	ADJ
admet-1476	80	13	signal	signal	NOUN
admet-1476	80	14	detection	detection	NOUN
admet-1476	80	15	or	or	CCONJ
admet-1476	80	16	high	high	ADJ
admet-1476	80	17	turbidity	turbidity	NOUN
admet-1476	80	18	,	,	PUNCT
admet-1476	80	19	a	a	DET
admet-1476	80	20	higher	high	ADJ
admet-1476	80	21	or	or	CCONJ
admet-1476	80	22	lower	low	ADJ
admet-1476	80	23	dose	dose	NOUN
admet-1476	80	24	was	be	AUX
admet-1476	80	25	selected	select	VERB
admet-1476	80	26	.	.	PUNCT
admet-1476	81	1	the	the	DET
admet-1476	81	2	dose	dose	NOUN
admet-1476	81	3	used	use	VERB
admet-1476	81	4	for	for	ADP
admet-1476	81	5	each	each	DET
admet-1476	81	6	model	model	NOUN
admet-1476	81	7	compound	compound	NOUN
admet-1476	81	8	can	can	AUX
admet-1476	81	9	be	be	AUX
admet-1476	81	10	found	find	VERB
admet-1476	81	11	in	in	ADP
admet-1476	81	12	table	table	NOUN
admet-1476	81	13	3	3	NUM
admet-1476	81	14	.	.	PUNCT
admet-1476	82	1	the	the	DET
admet-1476	82	2	uv	uv	PROPN
admet-1476	82	3	spectra	spectra	NOUN
admet-1476	82	4	in	in	ADP
admet-1476	82	5	donor	donor	NOUN
admet-1476	82	6	and	and	CCONJ
admet-1476	82	7	receiver	receiver	ADJ
admet-1476	82	8	chambers	chamber	NOUN
admet-1476	82	9	were	be	AUX
admet-1476	82	10	monitored	monitor	VERB
admet-1476	82	11	simultaneously	simultaneously	ADV
admet-1476	82	12	using	use	VERB
admet-1476	82	13	uv	uv	NOUN
admet-1476	82	14	-	-	PUNCT
admet-1476	82	15	vis	vis	X
admet-1476	82	16	fiber	fiber	NOUN
admet-1476	82	17	optic	optic	NOUN
admet-1476	82	18	probes	probe	NOUN
admet-1476	82	19	(	(	PUNCT
admet-1476	82	20	tips	tip	NOUN
admet-1476	82	21	path	path	NOUN
admet-1476	82	22	length	length	NOUN
admet-1476	82	23	2	2	NUM
admet-1476	82	24	-	-	SYM
admet-1476	82	25	20	20	NUM
admet-1476	82	26	mm	mm	NOUN
admet-1476	82	27	)	)	PUNCT
admet-1476	82	28	connected	connect	VERB
admet-1476	82	29	to	to	ADP
admet-1476	82	30	the	the	DET
admet-1476	82	31	rainbow	rainbow	NOUN
admet-1476	82	32	®	®	NOUN
admet-1476	82	33	instrument	instrument	NOUN
admet-1476	82	34	(	(	PUNCT
admet-1476	82	35	pion	pion	PROPN
admet-1476	82	36	inc	inc	PROPN
admet-1476	82	37	.	.	PROPN
admet-1476	82	38	,	,	PUNCT
admet-1476	82	39	billerica	billerica	PROPN
admet-1476	82	40	,	,	PUNCT
admet-1476	82	41	ma	ma	PROPN
admet-1476	82	42	,	,	PUNCT
admet-1476	82	43	usa	usa	PROPN
admet-1476	82	44	)	)	PUNCT
admet-1476	82	45	and	and	CCONJ
admet-1476	82	46	were	be	AUX
admet-1476	82	47	analyzed	analyze	VERB
admet-1476	82	48	using	use	VERB
admet-1476	82	49	aupro	aupro	ADJ
admet-1476	82	50	software	software	NOUN
admet-1476	82	51	(	(	PUNCT
admet-1476	82	52	revision	revision	NOUN
admet-1476	82	53	6	6	NUM
admet-1476	82	54	or	or	CCONJ
admet-1476	82	55	higher	high	ADJ
admet-1476	82	56	)	)	PUNCT
admet-1476	82	57	to	to	PART
admet-1476	82	58	determine	determine	VERB
admet-1476	82	59	the	the	DET
admet-1476	82	60	apparent	apparent	ADJ
admet-1476	82	61	drug	drug	NOUN
admet-1476	82	62	concentration	concentration	NOUN
admet-1476	82	63	in	in	ADP
admet-1476	82	64	both	both	DET
admet-1476	82	65	chambers	chamber	NOUN
admet-1476	82	66	.	.	PUNCT
admet-1476	83	1	standards	standard	NOUN
admet-1476	83	2	for	for	ADP
admet-1476	83	3	each	each	DET
admet-1476	83	4	model	model	NOUN
admet-1476	83	5	compound	compound	NOUN
admet-1476	83	6	were	be	AUX
admet-1476	83	7	prepared	prepare	VERB
admet-1476	83	8	by	by	ADP
admet-1476	83	9	sequential	sequential	ADJ
admet-1476	83	10	addition	addition	NOUN
admet-1476	83	11	of	of	ADP
admet-1476	83	12	a	a	DET
admet-1476	83	13	stock	stock	NOUN
admet-1476	83	14	solution	solution	NOUN
admet-1476	83	15	of	of	ADP
admet-1476	83	16	pure	pure	ADJ
admet-1476	83	17	api	api	NOUN
admet-1476	83	18	pre	pre	VERB
admet-1476	83	19	-	-	VERB
admet-1476	83	20	dissolved	dissolved	ADJ
admet-1476	83	21	in	in	ADP
admet-1476	83	22	organic	organic	ADJ
admet-1476	83	23	solvents	solvent	NOUN
admet-1476	83	24	(	(	PUNCT
admet-1476	83	25	either	either	CCONJ
admet-1476	83	26	methanol	methanol	NOUN
admet-1476	83	27	or	or	CCONJ
admet-1476	83	28	dmso	dmso	NOUN
admet-1476	83	29	)	)	PUNCT
admet-1476	83	30	to	to	ADP
admet-1476	83	31	the	the	DET
admet-1476	83	32	corresponding	corresponding	ADJ
admet-1476	83	33	medium	medium	NOUN
admet-1476	83	34	.	.	PUNCT
admet-1476	84	1	the	the	DET
admet-1476	84	2	area	area	NOUN
admet-1476	84	3	under	under	ADP
admet-1476	84	4	the	the	DET
admet-1476	84	5	2nd	2nd	ADJ
admet-1476	84	6	derivative	derivative	ADJ
admet-1476	84	7	spectra	spectra	ADJ
admet-1476	84	8	curves	curve	NOUN
admet-1476	84	9	was	be	AUX
admet-1476	84	10	used	use	VERB
admet-1476	84	11	to	to	PART
admet-1476	84	12	calculate	calculate	VERB
admet-1476	84	13	the	the	DET
admet-1476	84	14	concentrations	concentration	NOUN
admet-1476	84	15	.	.	PUNCT
admet-1476	85	1	the	the	DET
admet-1476	85	2	wavelength	wavelength	NOUN
admet-1476	85	3	range	range	NOUN
admet-1476	85	4	was	be	AUX
admet-1476	85	5	selected	select	VERB
admet-1476	85	6	individually	individually	ADV
admet-1476	85	7	for	for	ADP
admet-1476	85	8	each	each	DET
admet-1476	85	9	compound	compound	NOUN
admet-1476	85	10	in	in	ADP
admet-1476	85	11	the	the	DET
admet-1476	85	12	way	way	NOUN
admet-1476	85	13	to	to	PART
admet-1476	85	14	avoid	avoid	VERB
admet-1476	85	15	sensitivity	sensitivity	NOUN
admet-1476	85	16	issues	issue	NOUN
admet-1476	85	17	.	.	PUNCT
admet-1476	86	1	linearity	linearity	NOUN
admet-1476	86	2	of	of	ADP
admet-1476	86	3	the	the	DET
admet-1476	86	4	standard	standard	ADJ
admet-1476	86	5	curves	curve	NOUN
admet-1476	86	6	in	in	ADP
admet-1476	86	7	the	the	DET
admet-1476	86	8	selected	select	VERB
admet-1476	86	9	wavelength	wavelength	NOUN
admet-1476	86	10	regions	region	NOUN
admet-1476	86	11	were	be	AUX
admet-1476	86	12	characterized	characterize	VERB
admet-1476	86	13	by	by	ADP
admet-1476	86	14	r2	r2	PROPN
admet-1476	86	15	≥	≥	NUM
admet-1476	86	16	0.998	0.998	NUM
admet-1476	86	17	.	.	PUNCT
admet-1476	87	1	the	the	DET
admet-1476	87	2	drug	drug	NOUN
admet-1476	87	3	concentration	concentration	NOUN
admet-1476	87	4	in	in	ADP
admet-1476	87	5	the	the	DET
admet-1476	87	6	donor	donor	NOUN
admet-1476	87	7	admet	admet	PROPN
admet-1476	87	8	&	&	CCONJ
admet-1476	87	9	dmpk	dmpk	PROPN
admet-1476	87	10	x(y	x(y	PROPN
admet-1476	87	11	)	)	PUNCT
admet-1476	87	12	(	(	PUNCT
admet-1476	87	13	20xx	20xx	NOUN
admet-1476	87	14	)	)	PUNCT
admet-1476	87	15	000	000	NUM
admet-1476	87	16	-	-	PUNCT
admet-1476	87	17	000	000	NUM
admet-1476	87	18	material	material	NOUN
admet-1476	87	19	sparing	sparing	NOUN
admet-1476	87	20	µflux	µflux	NOUN
admet-1476	87	21	methodology	methodology	NOUN
admet-1476	87	22	doi	doi	NOUN
admet-1476	87	23	:	:	PUNCT
admet-1476	87	24	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	NOUN
admet-1476	87	25	303	303	NUM
admet-1476	87	26	and	and	CCONJ
admet-1476	87	27	receiver	receiver	ADJ
admet-1476	87	28	chambers	chamber	NOUN
admet-1476	87	29	was	be	AUX
admet-1476	87	30	calculated	calculate	VERB
admet-1476	87	31	from	from	ADP
admet-1476	87	32	the	the	DET
admet-1476	87	33	uv	uv	NOUN
admet-1476	87	34	absorbance	absorbance	NOUN
admet-1476	87	35	of	of	ADP
admet-1476	87	36	the	the	DET
admet-1476	87	37	samples	sample	NOUN
admet-1476	87	38	using	use	VERB
admet-1476	87	39	the	the	DET
admet-1476	87	40	corresponding	corresponding	ADJ
admet-1476	87	41	standard	standard	ADJ
admet-1476	87	42	curve	curve	NOUN
admet-1476	87	43	.	.	PUNCT
admet-1476	88	1	for	for	ADP
admet-1476	88	2	samples	sample	NOUN
admet-1476	88	3	with	with	ADP
admet-1476	88	4	low	low	ADJ
admet-1476	88	5	permeability	permeability	NOUN
admet-1476	88	6	,	,	PUNCT
admet-1476	88	7	an	an	DET
admet-1476	88	8	additional	additional	ADJ
admet-1476	88	9	µflux	µflux	NOUN
admet-1476	88	10	donor	donor	NOUN
admet-1476	88	11	-	-	PUNCT
admet-1476	88	12	receiver	receiver	NOUN
admet-1476	88	13	pair	pair	NOUN
admet-1476	88	14	containing	contain	VERB
admet-1476	88	15	described	describe	VERB
admet-1476	88	16	reagents	reagent	NOUN
admet-1476	88	17	except	except	SCONJ
admet-1476	88	18	api	api	NOUN
admet-1476	88	19	was	be	AUX
admet-1476	88	20	included	include	VERB
admet-1476	88	21	in	in	ADP
admet-1476	88	22	parallels	parallel	NOUN
admet-1476	88	23	and	and	CCONJ
admet-1476	88	24	used	use	VERB
admet-1476	88	25	as	as	ADP
admet-1476	88	26	a	a	DET
admet-1476	88	27	corrective	corrective	ADJ
admet-1476	88	28	“	"	PUNCT
admet-1476	88	29	blank	blank	NOUN
admet-1476	88	30	”	"	PUNCT
admet-1476	88	31	at	at	ADP
admet-1476	88	32	the	the	DET
admet-1476	88	33	corresponding	corresponding	ADJ
admet-1476	88	34	time	time	NOUN
admet-1476	88	35	point	point	NOUN
admet-1476	88	36	to	to	PART
admet-1476	88	37	ensure	ensure	VERB
admet-1476	88	38	that	that	SCONJ
admet-1476	88	39	the	the	DET
admet-1476	88	40	uv	uv	NOUN
admet-1476	88	41	signal	signal	NOUN
admet-1476	88	42	of	of	ADP
admet-1476	88	43	api	api	NOUN
admet-1476	88	44	could	could	AUX
admet-1476	88	45	be	be	AUX
admet-1476	88	46	differentiated	differentiate	VERB
admet-1476	88	47	from	from	ADP
admet-1476	88	48	the	the	DET
admet-1476	88	49	spectral	spectral	ADJ
admet-1476	88	50	noise	noise	NOUN
admet-1476	88	51	of	of	ADP
admet-1476	88	52	the	the	DET
admet-1476	88	53	biorelevant	biorelevant	ADJ
admet-1476	88	54	media	medium	NOUN
admet-1476	88	55	.	.	PUNCT
admet-1476	89	1	concentration	concentration	NOUN
admet-1476	89	2	-	-	PUNCT
admet-1476	89	3	time	time	NOUN
admet-1476	89	4	profiles	profile	NOUN
admet-1476	89	5	were	be	AUX
admet-1476	89	6	monitored	monitor	VERB
admet-1476	89	7	over	over	ADP
admet-1476	89	8	at	at	ADV
admet-1476	89	9	least	least	ADV
admet-1476	89	10	180	180	NUM
admet-1476	89	11	min	min	NOUN
admet-1476	89	12	,	,	PUNCT
admet-1476	89	13	in	in	ADP
admet-1476	89	14	triplicate	triplicate	NOUN
admet-1476	89	15	for	for	ADP
admet-1476	89	16	each	each	DET
admet-1476	89	17	drug	drug	NOUN
admet-1476	89	18	unless	unless	SCONJ
admet-1476	89	19	otherwise	otherwise	ADV
admet-1476	89	20	mentioned	mention	VERB
admet-1476	89	21	.	.	PUNCT
admet-1476	90	1	the	the	DET
admet-1476	90	2	flux	flux	NOUN
admet-1476	90	3	(	(	PUNCT
admet-1476	90	4	j	j	NOUN
admet-1476	90	5	)	)	PUNCT
admet-1476	90	6	across	across	ADP
admet-1476	90	7	the	the	DET
admet-1476	90	8	membrane	membrane	NOUN
admet-1476	90	9	representing	represent	VERB
admet-1476	90	10	the	the	DET
admet-1476	90	11	amount	amount	NOUN
admet-1476	90	12	(	(	PUNCT
admet-1476	90	13	m	m	NOUN
admet-1476	90	14	)	)	PUNCT
admet-1476	90	15	of	of	ADP
admet-1476	90	16	material	material	NOUN
admet-1476	90	17	crossing	cross	VERB
admet-1476	90	18	one	one	NUM
admet-1476	90	19	unit	unit	NOUN
admet-1476	90	20	area	area	NOUN
admet-1476	90	21	(	(	PUNCT
admet-1476	90	22	a	a	NOUN
admet-1476	90	23	)	)	PUNCT
admet-1476	90	24	of	of	ADP
admet-1476	90	25	the	the	DET
admet-1476	90	26	membrane	membrane	NOUN
admet-1476	90	27	per	per	ADP
admet-1476	90	28	unit	unit	NOUN
admet-1476	90	29	time	time	NOUN
admet-1476	90	30	(	(	PUNCT
admet-1476	90	31	t	t	PROPN
admet-1476	90	32	)	)	PUNCT
admet-1476	90	33	,	,	PUNCT
admet-1476	90	34	was	be	AUX
admet-1476	90	35	calculated	calculate	VERB
admet-1476	90	36	from	from	ADP
admet-1476	90	37	the	the	DET
admet-1476	90	38	concentration	concentration	NOUN
admet-1476	90	39	-	-	PUNCT
admet-1476	90	40	time	time	NOUN
admet-1476	90	41	profiles	profile	NOUN
admet-1476	90	42	in	in	ADP
admet-1476	90	43	the	the	DET
admet-1476	90	44	receiver	receiver	ADJ
admet-1476	90	45	compartments	compartment	NOUN
admet-1476	90	46	:	:	PUNCT
admet-1476	90	47	𝐽(𝑡	𝐽(𝑡	X
admet-1476	90	48	)	)	PUNCT
admet-1476	90	49	=	=	SYM
admet-1476	90	50	d𝑚	d𝑚	NOUN
admet-1476	90	51	𝐴.d𝑡	𝐴.d𝑡	PROPN
admet-1476	90	52	=	=	SYM
admet-1476	90	53	𝑉	𝑉	PROPN
admet-1476	90	54	𝐴	𝐴	PROPN
admet-1476	90	55	.	.	PUNCT
admet-1476	91	1	d𝑐	d𝑐	PROPN
admet-1476	91	2	d𝑡	d𝑡	INTJ
admet-1476	91	3	(	(	PUNCT
admet-1476	91	4	1	1	NUM
admet-1476	91	5	)	)	PUNCT
admet-1476	91	6	a	a	PRON
admet-1476	91	7	is	be	AUX
admet-1476	91	8	the	the	DET
admet-1476	91	9	area	area	NOUN
admet-1476	91	10	of	of	ADP
admet-1476	91	11	the	the	DET
admet-1476	91	12	membrane	membrane	NOUN
admet-1476	91	13	(	(	PUNCT
admet-1476	91	14	1.54	1.54	NUM
admet-1476	91	15	cm2	cm2	NOUN
admet-1476	91	16	)	)	PUNCT
admet-1476	91	17	,	,	PUNCT
admet-1476	91	18	v	v	NOUN
admet-1476	91	19	is	be	AUX
admet-1476	91	20	the	the	DET
admet-1476	91	21	volume	volume	NOUN
admet-1476	91	22	of	of	ADP
admet-1476	91	23	the	the	DET
admet-1476	91	24	receiver	receiver	ADJ
admet-1476	91	25	compartment	compartment	NOUN
admet-1476	91	26	(	(	PUNCT
admet-1476	91	27	20	20	NUM
admet-1476	91	28	ml	ml	NOUN
admet-1476	91	29	)	)	PUNCT
admet-1476	91	30	and	and	CCONJ
admet-1476	91	31	dc	dc	PROPN
admet-1476	91	32	/	/	SYM
admet-1476	91	33	dt	dt	PROPN
admet-1476	91	34	(	(	PUNCT
admet-1476	91	35	µg	µg	ADV
admet-1476	91	36	ml-1	ml-1	PRON
admet-1476	91	37	min-1	min-1	NOUN
admet-1476	91	38	)	)	PUNCT
admet-1476	91	39	is	be	AUX
admet-1476	91	40	the	the	DET
admet-1476	91	41	slope	slope	NOUN
admet-1476	91	42	of	of	ADP
admet-1476	91	43	the	the	DET
admet-1476	91	44	concentration	concentration	NOUN
admet-1476	91	45	time	time	NOUN
admet-1476	91	46	profile	profile	NOUN
admet-1476	91	47	of	of	ADP
admet-1476	91	48	the	the	DET
admet-1476	91	49	drug	drug	NOUN
admet-1476	91	50	in	in	ADP
admet-1476	91	51	the	the	DET
admet-1476	91	52	receiver	receiver	ADJ
admet-1476	91	53	compartment	compartment	NOUN
admet-1476	91	54	.	.	PUNCT
admet-1476	92	1	the	the	DET
admet-1476	92	2	flux	flux	NOUN
admet-1476	92	3	values	value	NOUN
admet-1476	92	4	were	be	AUX
admet-1476	92	5	calculated	calculate	VERB
admet-1476	92	6	by	by	ADP
admet-1476	92	7	fitting	fit	VERB
admet-1476	92	8	the	the	DET
admet-1476	92	9	concentration	concentration	NOUN
admet-1476	92	10	-	-	PUNCT
admet-1476	92	11	time	time	NOUN
admet-1476	92	12	profile	profile	NOUN
admet-1476	92	13	in	in	ADP
admet-1476	92	14	the	the	DET
admet-1476	92	15	receivers	receiver	NOUN
admet-1476	92	16	to	to	ADP
admet-1476	92	17	a	a	DET
admet-1476	92	18	straight	straight	ADJ
admet-1476	92	19	line	line	NOUN
admet-1476	92	20	to	to	PART
admet-1476	92	21	determine	determine	VERB
admet-1476	92	22	the	the	DET
admet-1476	92	23	slope	slope	NOUN
admet-1476	92	24	and	and	CCONJ
admet-1476	92	25	then	then	ADV
admet-1476	92	26	normalizing	normalize	VERB
admet-1476	92	27	the	the	DET
admet-1476	92	28	slope	slope	NOUN
admet-1476	92	29	to	to	ADP
admet-1476	92	30	the	the	DET
admet-1476	92	31	volume	volume	NOUN
admet-1476	92	32	and	and	CCONJ
admet-1476	92	33	surface	surface	NOUN
admet-1476	92	34	area	area	NOUN
admet-1476	92	35	of	of	ADP
admet-1476	92	36	the	the	DET
admet-1476	92	37	membrane	membrane	NOUN
admet-1476	92	38	following	follow	VERB
admet-1476	92	39	equation	equation	NOUN
admet-1476	92	40	(	(	PUNCT
admet-1476	92	41	1	1	NUM
admet-1476	92	42	)	)	PUNCT
admet-1476	92	43	.	.	PUNCT
admet-1476	93	1	time	time	NOUN
admet-1476	93	2	intervals	interval	NOUN
admet-1476	93	3	to	to	PART
admet-1476	93	4	calculate	calculate	VERB
admet-1476	93	5	the	the	DET
admet-1476	93	6	flux	flux	NOUN
admet-1476	93	7	were	be	AUX
admet-1476	93	8	selected	select	VERB
admet-1476	93	9	based	base	VERB
admet-1476	93	10	on	on	ADP
admet-1476	93	11	the	the	DET
admet-1476	93	12	apparent	apparent	ADJ
admet-1476	93	13	linearity	linearity	NOUN
admet-1476	93	14	of	of	ADP
admet-1476	93	15	the	the	DET
admet-1476	93	16	concentration	concentration	NOUN
admet-1476	93	17	-	-	PUNCT
admet-1476	93	18	time	time	NOUN
admet-1476	93	19	profile	profile	NOUN
admet-1476	93	20	in	in	ADP
admet-1476	93	21	the	the	DET
admet-1476	93	22	receivers	receiver	NOUN
admet-1476	93	23	,	,	PUNCT
admet-1476	93	24	capturing	capture	VERB
admet-1476	93	25	the	the	DET
admet-1476	93	26	initial	initial	ADJ
admet-1476	93	27	flux	flux	NOUN
admet-1476	93	28	process	process	NOUN
admet-1476	93	29	and	and	CCONJ
admet-1476	93	30	excluding	exclude	VERB
admet-1476	93	31	the	the	DET
admet-1476	93	32	lag	lag	NOUN
admet-1476	93	33	time	time	NOUN
admet-1476	93	34	unless	unless	SCONJ
admet-1476	93	35	otherwise	otherwise	ADV
admet-1476	93	36	is	be	AUX
admet-1476	93	37	stated	state	VERB
admet-1476	93	38	.	.	PUNCT
admet-1476	94	1	the	the	DET
admet-1476	94	2	solubility	solubility	NOUN
admet-1476	94	3	in	in	ADP
admet-1476	94	4	biorelevant	biorelevant	ADJ
admet-1476	94	5	media	medium	NOUN
admet-1476	94	6	was	be	AUX
admet-1476	94	7	determined	determine	VERB
admet-1476	94	8	in	in	ADP
admet-1476	94	9	our	our	PRON
admet-1476	94	10	lab	lab	NOUN
admet-1476	94	11	for	for	ADP
admet-1476	94	12	such	such	ADJ
admet-1476	94	13	compounds	compound	NOUN
admet-1476	94	14	where	where	SCONJ
admet-1476	94	15	the	the	DET
admet-1476	94	16	solubility	solubility	NOUN
admet-1476	94	17	could	could	AUX
admet-1476	94	18	not	not	PART
admet-1476	94	19	be	be	AUX
admet-1476	94	20	found	find	VERB
admet-1476	94	21	in	in	ADP
admet-1476	94	22	the	the	DET
admet-1476	94	23	literature	literature	NOUN
admet-1476	94	24	.	.	PUNCT
admet-1476	95	1	solubility	solubility	NOUN
admet-1476	95	2	measurements	measurement	NOUN
admet-1476	95	3	were	be	AUX
admet-1476	95	4	performed	perform	VERB
admet-1476	95	5	by	by	ADP
admet-1476	95	6	adding	add	VERB
admet-1476	95	7	an	an	DET
admet-1476	95	8	excess	excess	ADJ
admet-1476	95	9	amount	amount	NOUN
admet-1476	95	10	of	of	ADP
admet-1476	95	11	drug	drug	NOUN
admet-1476	95	12	into	into	ADP
admet-1476	95	13	fassif	fassif	NOUN
admet-1476	95	14	or	or	CCONJ
admet-1476	95	15	fessif	fessif	VERB
admet-1476	95	16	media	medium	NOUN
admet-1476	95	17	in	in	ADP
admet-1476	95	18	a	a	DET
admet-1476	95	19	glass	glass	NOUN
admet-1476	95	20	vial	vial	NOUN
admet-1476	95	21	.	.	PUNCT
admet-1476	96	1	the	the	DET
admet-1476	96	2	vials	vial	NOUN
admet-1476	96	3	were	be	AUX
admet-1476	96	4	placed	place	VERB
admet-1476	96	5	on	on	ADP
admet-1476	96	6	an	an	DET
admet-1476	96	7	end	end	NOUN
admet-1476	96	8	over	over	ADP
admet-1476	96	9	end	end	NOUN
admet-1476	96	10	rotator	rotator	NOUN
admet-1476	96	11	into	into	ADP
admet-1476	96	12	a	a	DET
admet-1476	96	13	37	37	NUM
admet-1476	96	14	°	°	NOUN
admet-1476	96	15	c	c	NOUN
admet-1476	96	16	oven	oven	NOUN
admet-1476	96	17	for	for	ADP
admet-1476	96	18	24	24	NUM
admet-1476	96	19	hours	hour	NOUN
admet-1476	96	20	.	.	PUNCT
admet-1476	97	1	after	after	ADP
admet-1476	97	2	equilibration	equilibration	NOUN
admet-1476	97	3	,	,	PUNCT
admet-1476	97	4	samples	sample	NOUN
admet-1476	97	5	were	be	AUX
admet-1476	97	6	centrifuged	centrifuge	VERB
admet-1476	97	7	/	/	SYM
admet-1476	97	8	filtered	filter	VERB
admet-1476	97	9	using	use	VERB
admet-1476	97	10	nanosep	nanosep	PRON
admet-1476	97	11	with	with	ADP
admet-1476	97	12	0.2	0.2	NUM
admet-1476	97	13	µm	µm	ADP
admet-1476	97	14	bio	bio	ADJ
admet-1476	97	15	-	-	ADJ
admet-1476	97	16	inert	inert	ADJ
admet-1476	97	17	centrifugal	centrifugal	ADJ
admet-1476	97	18	devices	device	NOUN
admet-1476	97	19	(	(	PUNCT
admet-1476	97	20	pal	pal	ADJ
admet-1476	97	21	corporation	corporation	NOUN
admet-1476	97	22	)	)	PUNCT
admet-1476	97	23	.	.	PUNCT
admet-1476	98	1	the	the	DET
admet-1476	98	2	filtrate	filtrate	NOUN
admet-1476	98	3	was	be	AUX
admet-1476	98	4	immediately	immediately	ADV
admet-1476	98	5	diluted	dilute	VERB
admet-1476	98	6	accordingly	accordingly	ADV
admet-1476	98	7	into	into	ADP
admet-1476	98	8	acetonitrile	acetonitrile	NOUN
admet-1476	98	9	/	/	SYM
admet-1476	98	10	water	water	NOUN
admet-1476	98	11	50/50	50/50	NUM
admet-1476	98	12	and	and	CCONJ
admet-1476	98	13	analyzed	analyze	VERB
admet-1476	98	14	by	by	ADP
admet-1476	98	15	hplc	hplc	PROPN
admet-1476	98	16	.	.	PUNCT
admet-1476	99	1	results	result	NOUN
admet-1476	99	2	and	and	CCONJ
admet-1476	99	3	discussion	discussion	NOUN
admet-1476	99	4	model	model	NOUN
admet-1476	99	5	drugs	drug	NOUN
admet-1476	99	6	categorized	categorize	VERB
admet-1476	99	7	as	as	ADP
admet-1476	99	8	bcs	bcs	NOUN
admet-1476	99	9	i	i	PRON
admet-1476	99	10	iv	iv	VERB
admet-1476	99	11	classes	class	NOUN
admet-1476	99	12	were	be	AUX
admet-1476	99	13	selected	select	VERB
admet-1476	99	14	.	.	PUNCT
admet-1476	100	1	the	the	DET
admet-1476	100	2	drugs	drug	NOUN
admet-1476	100	3	included	include	VERB
admet-1476	100	4	monoand	monoand	NOUN
admet-1476	100	5	diprotic	diprotic	ADJ
admet-1476	100	6	acids	acid	NOUN
admet-1476	100	7	and	and	CCONJ
admet-1476	100	8	bases	basis	NOUN
admet-1476	100	9	as	as	ADV
admet-1476	100	10	well	well	ADV
admet-1476	100	11	as	as	ADP
admet-1476	100	12	non	non	ADJ
admet-1476	100	13	-	-	ADJ
admet-1476	100	14	ionizable	ionizable	ADJ
admet-1476	100	15	compounds	compound	NOUN
admet-1476	100	16	.	.	PUNCT
admet-1476	101	1	uv	uv	NOUN
admet-1476	101	2	properties	property	NOUN
admet-1476	101	3	of	of	ADP
admet-1476	101	4	the	the	DET
admet-1476	101	5	samples	sample	NOUN
admet-1476	101	6	were	be	AUX
admet-1476	101	7	also	also	ADV
admet-1476	101	8	taken	take	VERB
admet-1476	101	9	into	into	ADP
admet-1476	101	10	consideration	consideration	NOUN
admet-1476	101	11	,	,	PUNCT
admet-1476	101	12	selecting	select	VERB
admet-1476	101	13	compounds	compound	NOUN
admet-1476	101	14	with	with	ADP
admet-1476	101	15	sufficient	sufficient	ADJ
admet-1476	101	16	uv	uv	NOUN
admet-1476	101	17	chromophores	chromophore	NOUN
admet-1476	101	18	to	to	PART
admet-1476	101	19	reduce	reduce	VERB
admet-1476	101	20	spectral	spectral	ADJ
admet-1476	101	21	interaction	interaction	NOUN
admet-1476	101	22	between	between	ADP
admet-1476	101	23	ds	ds	ADV
admet-1476	101	24	and	and	CCONJ
admet-1476	101	25	strongly	strongly	ADV
admet-1476	101	26	absorbing	absorb	VERB
admet-1476	101	27	biorelevant	biorelevant	ADJ
admet-1476	101	28	media	medium	NOUN
admet-1476	101	29	during	during	ADP
admet-1476	101	30	in	in	ADP
admet-1476	101	31	situ	situ	ADJ
admet-1476	101	32	concentration	concentration	NOUN
admet-1476	101	33	monitoring	monitoring	NOUN
admet-1476	101	34	in	in	ADP
admet-1476	101	35	donor	donor	NOUN
admet-1476	101	36	compartments	compartment	NOUN
admet-1476	101	37	of	of	ADP
admet-1476	101	38	µflux	µflux	NOUN
admet-1476	101	39	pairs	pair	NOUN
admet-1476	101	40	.	.	PUNCT
admet-1476	102	1	the	the	DET
admet-1476	102	2	physicochemical	physicochemical	ADJ
admet-1476	102	3	properties	property	NOUN
admet-1476	102	4	of	of	ADP
admet-1476	102	5	the	the	DET
admet-1476	102	6	model	model	NOUN
admet-1476	102	7	compounds	compound	NOUN
admet-1476	102	8	,	,	PUNCT
admet-1476	102	9	pka	pka	PROPN
admet-1476	102	10	,	,	PUNCT
admet-1476	102	11	log	log	VERB
admet-1476	102	12	p	p	NOUN
admet-1476	102	13	[	[	X
admet-1476	102	14	18,19	18,19	X
admet-1476	102	15	]	]	PUNCT
admet-1476	102	16	and	and	CCONJ
admet-1476	102	17	solubility	solubility	NOUN
admet-1476	102	18	in	in	ADP
admet-1476	102	19	biorelevant	biorelevant	ADJ
admet-1476	102	20	media	medium	NOUN
admet-1476	102	21	[	[	X
admet-1476	102	22	20	20	NUM
admet-1476	102	23	-	-	SYM
admet-1476	102	24	26	26	NUM
admet-1476	102	25	]	]	PUNCT
admet-1476	102	26	were	be	AUX
admet-1476	102	27	collected	collect	VERB
admet-1476	102	28	from	from	ADP
admet-1476	102	29	the	the	DET
admet-1476	102	30	literature	literature	NOUN
admet-1476	102	31	and	and	CCONJ
admet-1476	102	32	are	be	AUX
admet-1476	102	33	depicted	depict	VERB
admet-1476	102	34	in	in	ADP
admet-1476	102	35	table	table	NOUN
admet-1476	102	36	2	2	NUM
admet-1476	102	37	.	.	PUNCT
admet-1476	103	1	the	the	DET
admet-1476	103	2	solubility	solubility	NOUN
admet-1476	103	3	was	be	AUX
admet-1476	103	4	also	also	ADV
admet-1476	103	5	determined	determined	ADJ
admet-1476	103	6	in	in	ADP
admet-1476	103	7	our	our	PRON
admet-1476	103	8	lab	lab	NOUN
admet-1476	103	9	for	for	ADP
admet-1476	103	10	such	such	ADJ
admet-1476	103	11	compounds	compound	NOUN
admet-1476	103	12	where	where	SCONJ
admet-1476	103	13	the	the	DET
admet-1476	103	14	solubility	solubility	NOUN
admet-1476	103	15	could	could	AUX
admet-1476	103	16	not	not	PART
admet-1476	103	17	be	be	AUX
admet-1476	103	18	found	find	VERB
admet-1476	103	19	in	in	ADP
admet-1476	103	20	the	the	DET
admet-1476	103	21	literature	literature	NOUN
admet-1476	103	22	.	.	PUNCT
admet-1476	104	1	table	table	NOUN
admet-1476	104	2	3	3	NUM
admet-1476	104	3	compares	compare	VERB
admet-1476	104	4	the	the	DET
admet-1476	104	5	physicochemical	physicochemical	ADJ
admet-1476	104	6	properties	property	NOUN
admet-1476	104	7	,	,	PUNCT
admet-1476	104	8	the	the	DET
admet-1476	104	9	food	food	NOUN
admet-1476	104	10	effect	effect	NOUN
admet-1476	104	11	from	from	ADP
admet-1476	104	12	clinical	clinical	ADJ
admet-1476	104	13	data	datum	NOUN
admet-1476	104	14	and	and	CCONJ
admet-1476	104	15	the	the	DET
admet-1476	104	16	measured	measured	ADJ
admet-1476	104	17	flux	flux	NOUN
admet-1476	104	18	of	of	ADP
admet-1476	104	19	the	the	DET
admet-1476	104	20	model	model	NOUN
admet-1476	104	21	compounds	compound	VERB
admet-1476	104	22	.	.	PUNCT
admet-1476	105	1	the	the	DET
admet-1476	105	2	solubility	solubility	NOUN
admet-1476	105	3	ratio	ratio	NOUN
admet-1476	105	4	(	(	PUNCT
admet-1476	105	5	fed	fed	PROPN
admet-1476	105	6	/	/	SYM
admet-1476	105	7	fasted	fast	VERB
admet-1476	105	8	)	)	PUNCT
admet-1476	105	9	was	be	AUX
admet-1476	105	10	calculated	calculate	VERB
admet-1476	105	11	from	from	ADP
admet-1476	105	12	the	the	DET
admet-1476	105	13	experimental	experimental	ADJ
admet-1476	105	14	solubility	solubility	NOUN
admet-1476	105	15	in	in	ADP
admet-1476	105	16	biorelevant	biorelevant	ADJ
admet-1476	105	17	media	medium	NOUN
admet-1476	105	18	obtained	obtain	VERB
admet-1476	105	19	from	from	ADP
admet-1476	105	20	the	the	DET
admet-1476	105	21	literature	literature	NOUN
admet-1476	105	22	(	(	PUNCT
admet-1476	105	23	table	table	NOUN
admet-1476	105	24	2	2	NUM
admet-1476	105	25	)	)	PUNCT
admet-1476	105	26	.	.	PUNCT
admet-1476	106	1	the	the	DET
admet-1476	106	2	pk	pk	PROPN
admet-1476	106	3	parameters	parameter	NOUN
admet-1476	106	4	,	,	PUNCT
admet-1476	106	5	the	the	DET
admet-1476	106	6	total	total	ADJ
admet-1476	106	7	drug	drug	NOUN
admet-1476	106	8	exposure	exposure	NOUN
admet-1476	106	9	auc	auc	NOUN
admet-1476	106	10	,	,	PUNCT
admet-1476	106	11	and	and	CCONJ
admet-1476	106	12	the	the	DET
admet-1476	106	13	maximum	maximum	ADJ
admet-1476	106	14	concentration	concentration	NOUN
admet-1476	106	15	cmax	cmax	NOUN
admet-1476	106	16	in	in	ADP
admet-1476	106	17	the	the	DET
admet-1476	106	18	fasted	fast	VERB
admet-1476	106	19	and	and	CCONJ
admet-1476	106	20	fed	fed	PROPN
admet-1476	106	21	state	state	NOUN
admet-1476	106	22	were	be	AUX
admet-1476	106	23	obtained	obtain	VERB
admet-1476	106	24	from	from	ADP
admet-1476	106	25	the	the	DET
admet-1476	106	26	clinical	clinical	ADJ
admet-1476	106	27	data	datum	NOUN
admet-1476	106	28	published	publish	VERB
admet-1476	106	29	in	in	ADP
admet-1476	106	30	the	the	DET
admet-1476	106	31	literature	literature	NOUN
admet-1476	106	32	and	and	CCONJ
admet-1476	106	33	the	the	DET
admet-1476	106	34	ratio	ratio	NOUN
admet-1476	106	35	of	of	ADP
admet-1476	106	36	geometric	geometric	ADJ
admet-1476	106	37	means	mean	NOUN
admet-1476	106	38	between	between	ADP
admet-1476	106	39	fed	fed	PROPN
admet-1476	106	40	and	and	CCONJ
admet-1476	106	41	fasted	fast	VERB
admet-1476	106	42	state	state	NOUN
admet-1476	106	43	was	be	AUX
admet-1476	106	44	calculated	calculate	VERB
admet-1476	106	45	.	.	PUNCT
admet-1476	107	1	the	the	DET
admet-1476	107	2	food	food	NOUN
admet-1476	107	3	effect	effect	NOUN
admet-1476	107	4	was	be	AUX
admet-1476	107	5	assigned	assign	VERB
admet-1476	107	6	based	base	VERB
admet-1476	107	7	on	on	ADP
admet-1476	107	8	the	the	DET
admet-1476	107	9	auc	auc	NOUN
admet-1476	107	10	and	and	CCONJ
admet-1476	107	11	cmax	cmax	NOUN
admet-1476	107	12	ratios	ratio	NOUN
admet-1476	107	13	.	.	PUNCT
admet-1476	108	1	the	the	DET
admet-1476	108	2	food	food	NOUN
admet-1476	108	3	effect	effect	NOUN
admet-1476	108	4	on	on	ADP
admet-1476	108	5	the	the	DET
admet-1476	108	6	extend	extend	NOUN
admet-1476	108	7	of	of	ADP
admet-1476	108	8	absorption	absorption	NOUN
admet-1476	108	9	reported	report	VERB
admet-1476	108	10	in	in	ADP
admet-1476	108	11	the	the	DET
admet-1476	108	12	clinical	clinical	ADJ
admet-1476	108	13	studies	study	NOUN
admet-1476	108	14	were	be	AUX
admet-1476	108	15	listed	list	VERB
admet-1476	108	16	into	into	ADP
admet-1476	108	17	three	three	NUM
admet-1476	108	18	categories	category	NOUN
admet-1476	109	1	[	[	X
admet-1476	109	2	12	12	NUM
admet-1476	109	3	]	]	X
admet-1476	109	4	:	:	PUNCT
admet-1476	109	5	positive	positive	ADJ
admet-1476	109	6	food	food	NOUN
admet-1476	109	7	effect	effect	NOUN
admet-1476	109	8	(	(	PUNCT
admet-1476	109	9	auc	auc	X
admet-1476	109	10	and/or	and/or	CCONJ
admet-1476	109	11	cmax	cmax	VERB
admet-1476	109	12	increase	increase	NOUN
admet-1476	109	13	with	with	ADP
admet-1476	109	14	food	food	NOUN
admet-1476	109	15	,	,	PUNCT
admet-1476	109	16	4	4	NUM
admet-1476	109	17	compounds	compound	NOUN
admet-1476	109	18	)	)	PUNCT
admet-1476	109	19	,	,	PUNCT
admet-1476	109	20	negative	negative	ADJ
admet-1476	109	21	food	food	NOUN
admet-1476	109	22	effect	effect	NOUN
admet-1476	109	23	(	(	PUNCT
admet-1476	109	24	decrease	decrease	NOUN
admet-1476	109	25	in	in	ADP
admet-1476	109	26	auc	auc	NOUN
admet-1476	109	27	and/or	and/or	CCONJ
admet-1476	109	28	cmax	cmax	VERB
admet-1476	109	29	with	with	ADP
admet-1476	109	30	food	food	NOUN
admet-1476	109	31	,	,	PUNCT
admet-1476	109	32	4	4	NUM
admet-1476	109	33	compounds	compound	NOUN
admet-1476	109	34	)	)	PUNCT
admet-1476	109	35	and	and	CCONJ
admet-1476	109	36	no	no	DET
admet-1476	109	37	food	food	NOUN
admet-1476	109	38	effect	effect	NOUN
admet-1476	109	39	(	(	PUNCT
admet-1476	109	40	no	no	DET
admet-1476	109	41	significant	significant	ADJ
admet-1476	109	42	difference	difference	NOUN
admet-1476	109	43	with	with	ADP
admet-1476	109	44	food	food	NOUN
admet-1476	109	45	,	,	PUNCT
admet-1476	109	46	3	3	NUM
admet-1476	109	47	compounds	compound	NOUN
admet-1476	109	48	)	)	PUNCT
admet-1476	109	49	.	.	PUNCT
admet-1476	110	1	the	the	DET
admet-1476	110	2	concentration	concentration	NOUN
admet-1476	110	3	time	time	NOUN
admet-1476	110	4	profiles	profile	NOUN
admet-1476	110	5	obtained	obtain	VERB
admet-1476	110	6	in	in	ADP
admet-1476	110	7	the	the	DET
admet-1476	110	8	receiver	receiver	ADJ
admet-1476	110	9	chambers	chamber	NOUN
admet-1476	110	10	of	of	ADP
admet-1476	110	11	µflux	µflux	NOUN
admet-1476	110	12	pairs	pair	NOUN
admet-1476	110	13	were	be	AUX
admet-1476	110	14	used	use	VERB
admet-1476	110	15	to	to	PART
admet-1476	110	16	calculate	calculate	VERB
admet-1476	110	17	flux	flux	NOUN
admet-1476	110	18	values	value	NOUN
admet-1476	110	19	corresponding	correspond	VERB
admet-1476	110	20	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	ADJ
admet-1476	110	21	c.	c.	PROPN
admet-1476	110	22	jankovsky	jankovsky	PROPN
admet-1476	110	23	et	et	PROPN
admet-1476	110	24	al	al	PROPN
admet-1476	110	25	.	.	PROPN
admet-1476	110	26	admet	admet	PROPN
admet-1476	110	27	&	&	CCONJ
admet-1476	110	28	dmpk	dmpk	PROPN
admet-1476	110	29	10(4	10(4	NUM
admet-1476	110	30	)	)	PUNCT
admet-1476	110	31	(	(	PUNCT
admet-1476	110	32	2022	2022	NUM
admet-1476	110	33	)	)	PUNCT
admet-1476	110	34	299	299	NUM
admet-1476	110	35	-	-	SYM
admet-1476	110	36	314	314	NUM
admet-1476	110	37	304	304	NUM
admet-1476	110	38	to	to	ADP
admet-1476	110	39	the	the	DET
admet-1476	110	40	dissolution	dissolution	NOUN
admet-1476	110	41	in	in	ADP
admet-1476	110	42	the	the	DET
admet-1476	110	43	donor	donor	NOUN
admet-1476	110	44	chambers	chamber	NOUN
admet-1476	110	45	using	use	VERB
admet-1476	110	46	fassif	fassif	NOUN
admet-1476	110	47	or	or	CCONJ
admet-1476	110	48	fessif	fessif	VERB
admet-1476	110	49	media	medium	NOUN
admet-1476	110	50	.	.	PUNCT
admet-1476	111	1	the	the	DET
admet-1476	111	2	flux	flux	PROPN
admet-1476	111	3	ratio	ratio	NOUN
admet-1476	111	4	was	be	AUX
admet-1476	111	5	calculated	calculate	VERB
admet-1476	111	6	as	as	ADP
admet-1476	111	7	the	the	DET
admet-1476	111	8	ratio	ratio	NOUN
admet-1476	111	9	of	of	ADP
admet-1476	111	10	flux	flux	NOUN
admet-1476	111	11	from	from	ADP
admet-1476	111	12	the	the	DET
admet-1476	111	13	fed	fed	PROPN
admet-1476	111	14	(	(	PUNCT
admet-1476	111	15	fessif	fessif	ADJ
admet-1476	111	16	)	)	PUNCT
admet-1476	111	17	and	and	CCONJ
admet-1476	111	18	fasted	fast	VERB
admet-1476	111	19	(	(	PUNCT
admet-1476	111	20	fassif	fassif	NOUN
admet-1476	111	21	)	)	PUNCT
admet-1476	111	22	state	state	NOUN
admet-1476	111	23	.	.	PUNCT
admet-1476	112	1	the	the	DET
admet-1476	112	2	dose	dose	NOUN
admet-1476	112	3	of	of	ADP
admet-1476	112	4	the	the	DET
admet-1476	112	5	marketed	market	VERB
admet-1476	112	6	product	product	NOUN
admet-1476	112	7	used	use	VERB
admet-1476	112	8	in	in	ADP
admet-1476	112	9	the	the	DET
admet-1476	112	10	clinical	clinical	ADJ
admet-1476	112	11	studies	study	NOUN
admet-1476	112	12	and	and	CCONJ
admet-1476	112	13	the	the	DET
admet-1476	112	14	dose	dose	NOUN
admet-1476	112	15	used	use	VERB
admet-1476	112	16	in	in	ADP
admet-1476	112	17	the	the	DET
admet-1476	112	18	flux	flux	NOUN
admet-1476	112	19	measurements	measurement	NOUN
admet-1476	112	20	are	be	AUX
admet-1476	112	21	also	also	ADV
admet-1476	112	22	listed	list	VERB
admet-1476	112	23	in	in	ADP
admet-1476	112	24	table	table	NOUN
admet-1476	112	25	3	3	NUM
admet-1476	112	26	.	.	PUNCT
admet-1476	112	27	table	table	NOUN
admet-1476	112	28	2	2	NUM
admet-1476	112	29	.	.	PUNCT
admet-1476	112	30	experimental	experimental	ADJ
admet-1476	112	31	and	and	CCONJ
admet-1476	112	32	predicted	predict	VERB
admet-1476	112	33	pka	pka	PROPN
admet-1476	112	34	,	,	PUNCT
admet-1476	112	35	log	log	VERB
admet-1476	112	36	p	p	NOUN
admet-1476	112	37	and	and	CCONJ
admet-1476	112	38	solubility	solubility	NOUN
admet-1476	112	39	of	of	ADP
admet-1476	112	40	the	the	DET
admet-1476	112	41	study	study	NOUN
admet-1476	112	42	compounds	compound	VERB
admet-1476	112	43	model	model	NOUN
admet-1476	112	44	drug	drug	NOUN
admet-1476	112	45	bcs	bcs	NOUN
admet-1476	112	46	class	class	NOUN
admet-1476	112	47	type	type	NOUN
admet-1476	112	48	pka	pka	PROPN
admet-1476	112	49	log	log	NOUN
admet-1476	112	50	p	p	NOUN
admet-1476	112	51	solubility	solubility	NOUN
admet-1476	113	1	[	[	X
admet-1476	113	2	20	20	NUM
admet-1476	113	3	-	-	SYM
admet-1476	113	4	26	26	NUM
admet-1476	113	5	]	]	PUNCT
admet-1476	113	6	fassif	fassif	NOUN
admet-1476	113	7	(	(	PUNCT
admet-1476	113	8	ph	ph	NOUN
admet-1476	113	9	6.5	6.5	NUM
admet-1476	113	10	)	)	PUNCT
admet-1476	113	11	(	(	PUNCT
admet-1476	113	12	µg	µg	NOUN
admet-1476	113	13	/	/	SYM
admet-1476	113	14	ml	ml	NOUN
admet-1476	113	15	)	)	PUNCT
admet-1476	113	16	fessif	fessif	NOUN
admet-1476	113	17	(	(	PUNCT
admet-1476	113	18	ph	ph	NOUN
admet-1476	113	19	5.0	5.0	NUM
admet-1476	113	20	)	)	PUNCT
admet-1476	113	21	(	(	PUNCT
admet-1476	113	22	µg	µg	NOUN
admet-1476	113	23	/	/	SYM
admet-1476	113	24	ml	ml	NOUN
admet-1476	113	25	)	)	PUNCT
admet-1476	114	1	amiodarone	amiodarone	PROPN
admet-1476	114	2	ii	ii	PROPN
admet-1476	114	3	b	b	PROPN
admet-1476	114	4	10.24	10.24	NUM
admet-1476	114	5	±	±	NUM
admet-1476	114	6	0.15a	0.15a	NUM
admet-1476	115	1	7.80a	7.80a	NUM
admet-1476	115	2	351	351	NUM
admet-1476	115	3	784	784	NUM
admet-1476	115	4	celecoxib	celecoxib	NOUN
admet-1476	115	5	ii	ii	PROPN
admet-1476	115	6	a	a	DET
admet-1476	115	7	9.38	9.38	NUM
admet-1476	115	8	±	±	NUM
admet-1476	115	9	0.08a	0.08a	NOUN
admet-1476	115	10	3.02b	3.02b	NOUN
admet-1476	115	11	46.2	46.2	NUM
admet-1476	115	12	103.3	103.3	NUM
admet-1476	115	13	clopidogrel	clopidogrel	NOUN
admet-1476	115	14	bisulfate	bisulfate	VERB
admet-1476	115	15	ii	ii	PROPN
admet-1476	115	16	/	/	SYM
admet-1476	115	17	iv	iv	PROPN
admet-1476	115	18	b	b	PROPN
admet-1476	115	19	4.6b	4.6b	NUM
admet-1476	115	20	4.2b	4.2b	NOUN
admet-1476	115	21	130	130	NUM
admet-1476	115	22	500	500	NUM
admet-1476	115	23	danazol	danazol	ADJ
admet-1476	115	24	ii	ii	PROPN
admet-1476	115	25	n	n	PROPN
admet-1476	115	26	--4.70	--4.70	PROPN
admet-1476	116	1	+	+	PROPN
admet-1476	116	2	/0.43b	/0.43b	PROPN
admet-1476	116	3	8.4	8.4	NUM
admet-1476	116	4	28.8	28.8	NUM
admet-1476	116	5	fluoxetine	fluoxetine	NOUN
admet-1476	116	6	hydrochloride	hydrochloride	NOUN
admet-1476	116	7	i	i	PROPN
admet-1476	116	8	b	b	PROPN
admet-1476	116	9	9.62a	9.62a	NUM
admet-1476	116	10	4.50a	4.50a	NUM
admet-1476	116	11	1380	1380	NUM
admet-1476	116	12	1620	1620	NUM
admet-1476	116	13	furosemide	furosemide	NOUN
admet-1476	116	14	iv	iv	NUM
admet-1476	116	15	aa	aa	PROPN
admet-1476	116	16	9.90	9.90	NUM
admet-1476	116	17	±	±	NUM
admet-1476	116	18	0.04a	0.04a	PROPN
admet-1476	116	19	3.53	3.53	NUM
admet-1476	116	20	±	±	NUM
admet-1476	116	21	0.06a	0.06a	NUM
admet-1476	116	22	2.56a	2.56a	PROPN
admet-1476	116	23	3201	3201	NUM
admet-1476	116	24	684	684	NUM
admet-1476	116	25	griseofulvin	griseofulvin	NOUN
admet-1476	116	26	ii	ii	PROPN
admet-1476	116	27	n	n	PROPN
admet-1476	116	28	--2.20a	--2.20a	PROPN
admet-1476	116	29	23.4	23.4	NUM
admet-1476	116	30	29.2	29.2	NUM
admet-1476	116	31	isoniazid	isoniazid	NOUN
admet-1476	117	1	i	i	PRON
admet-1476	117	2	b	b	PROPN
admet-1476	117	3	3.8b	3.8b	NUM
admet-1476	117	4	-0.52b	-0.52b	X
admet-1476	117	5	>	>	X
admet-1476	117	6	60,000	60,000	NUM
admet-1476	117	7	>	>	SYM
admet-1476	117	8	60,000	60,000	NUM
admet-1476	117	9	nefazodone	nefazodone	NOUN
admet-1476	117	10	hcl	hcl	PROPN
admet-1476	117	11	ii	ii	PROPN
admet-1476	118	1	bb	bb	NUM
admet-1476	118	2	6.7b	6.7b	NUM
admet-1476	118	3	2.1b	2.1b	NUM
admet-1476	118	4	3.5b	3.5b	NUM
admet-1476	118	5	252	252	NUM
admet-1476	118	6	383	383	NUM
admet-1476	118	7	nifedipine	nifedipine	NOUN
admet-1476	118	8	ii	ii	PROPN
admet-1476	118	9	n	n	PROPN
admet-1476	118	10	--3.17a	--3.17a	PROPN
admet-1476	118	11	14.4	14.4	NUM
admet-1476	118	12	46.1	46.1	NUM
admet-1476	118	13	zidovudine	zidovudine	PROPN
admet-1476	118	14	iii	iii	PROPN
admet-1476	118	15	a	a	DET
admet-1476	118	16	9.40	9.40	NUM
admet-1476	118	17	±	±	NUM
admet-1476	118	18	0.01a	0.01a	NOUN
admet-1476	118	19	0.13a	0.13a	PUNCT
admet-1476	118	20	>	>	PUNCT
admet-1476	118	21	10,000	10,000	NUM
admet-1476	118	22	>	>	SYM
admet-1476	118	23	10,000	10,000	NUM
admet-1476	118	24	type	type	NOUN
admet-1476	118	25	:	:	PUNCT
admet-1476	118	26	a	a	DET
admet-1476	118	27	acid	acid	NOUN
admet-1476	118	28	;	;	PUNCT
admet-1476	118	29	aa	aa	PROPN
admet-1476	118	30	diprotic	diprotic	ADJ
admet-1476	118	31	acid	acid	NOUN
admet-1476	118	32	;	;	PUNCT
admet-1476	118	33	b	b	X
admet-1476	118	34	base	base	NOUN
admet-1476	118	35	;	;	PUNCT
admet-1476	118	36	bb	bb	NUM
admet-1476	118	37	diprotic	diprotic	ADJ
admet-1476	118	38	base	base	NOUN
admet-1476	118	39	;	;	PUNCT
admet-1476	118	40	n	n	CCONJ
admet-1476	118	41	neutral	neutral	VERB
admet-1476	118	42	a	a	DET
admet-1476	118	43	ref	ref	NOUN
admet-1476	118	44	.	.	PUNCT
admet-1476	119	1	[	[	X
admet-1476	119	2	18	18	NUM
admet-1476	119	3	]	]	SYM
admet-1476	119	4	b	b	DET
admet-1476	119	5	ref	ref	NOUN
admet-1476	119	6	.	.	PUNCT
admet-1476	120	1	[	[	X
admet-1476	120	2	19	19	NUM
admet-1476	120	3	]	]	X
admet-1476	120	4	it	it	PRON
admet-1476	120	5	is	be	AUX
admet-1476	120	6	evident	evident	ADJ
admet-1476	120	7	from	from	ADP
admet-1476	120	8	table	table	NOUN
admet-1476	120	9	3	3	NUM
admet-1476	120	10	that	that	PRON
admet-1476	120	11	for	for	ADP
admet-1476	120	12	most	most	ADJ
admet-1476	120	13	of	of	ADP
admet-1476	120	14	the	the	DET
admet-1476	120	15	model	model	NOUN
admet-1476	120	16	compounds	compound	NOUN
admet-1476	120	17	,	,	PUNCT
admet-1476	120	18	in	in	ADP
admet-1476	120	19	vitro	vitro	X
admet-1476	120	20	experiment	experiment	NOUN
admet-1476	120	21	i.e.	i.e.	X
admet-1476	120	22	,	,	PUNCT
admet-1476	120	23	flux	flux	PROPN
admet-1476	120	24	ratio	ratio	NOUN
admet-1476	120	25	predicted	predict	VERB
admet-1476	120	26	the	the	DET
admet-1476	120	27	fe	fe	NOUN
admet-1476	120	28	observed	observe	VERB
admet-1476	120	29	in	in	ADP
admet-1476	120	30	the	the	DET
admet-1476	120	31	clinic	clinic	NOUN
admet-1476	120	32	.	.	PUNCT
admet-1476	121	1	the	the	DET
admet-1476	121	2	results	result	NOUN
admet-1476	121	3	for	for	ADP
admet-1476	121	4	each	each	DET
admet-1476	121	5	model	model	NOUN
admet-1476	121	6	compound	compound	NOUN
admet-1476	121	7	are	be	AUX
admet-1476	121	8	discussed	discuss	VERB
admet-1476	121	9	below	below	ADV
admet-1476	121	10	.	.	PUNCT
admet-1476	122	1	amiodarone	amiodarone	NOUN
admet-1476	122	2	,	,	PUNCT
admet-1476	122	3	anti	anti	ADJ
admet-1476	122	4	-	-	ADJ
admet-1476	122	5	arrythmic	arrythmic	ADJ
admet-1476	122	6	drug	drug	NOUN
admet-1476	122	7	,	,	PUNCT
admet-1476	122	8	is	be	AUX
admet-1476	122	9	a	a	DET
admet-1476	122	10	bcs	bcs	NOUN
admet-1476	122	11	class	class	NOUN
admet-1476	122	12	ii	ii	PROPN
admet-1476	122	13	drug	drug	NOUN
admet-1476	122	14	with	with	ADP
admet-1476	122	15	~2.2	~2.2	NOUN
admet-1476	122	16	-	-	ADJ
admet-1476	122	17	fold	fold	ADJ
admet-1476	122	18	higher	high	ADJ
admet-1476	122	19	solubility	solubility	NOUN
admet-1476	122	20	in	in	ADP
admet-1476	122	21	fessif	fessif	NOUN
admet-1476	122	22	than	than	ADP
admet-1476	122	23	in	in	ADP
admet-1476	122	24	fassif	fassif	NOUN
admet-1476	122	25	.	.	PUNCT
admet-1476	123	1	the	the	DET
admet-1476	123	2	flux	flux	PROPN
admet-1476	123	3	ratio	ratio	NOUN
admet-1476	123	4	(	(	PUNCT
admet-1476	123	5	fessif	fessif	PROPN
admet-1476	123	6	/	/	SYM
admet-1476	123	7	fassif	fassif	NOUN
admet-1476	123	8	)	)	PUNCT
admet-1476	123	9	was	be	AUX
admet-1476	123	10	determined	determine	VERB
admet-1476	123	11	to	to	PART
admet-1476	123	12	be	be	AUX
admet-1476	123	13	4.25	4.25	NUM
admet-1476	123	14	at	at	ADP
admet-1476	123	15	earlier	early	ADJ
admet-1476	123	16	time	time	NOUN
admet-1476	123	17	point	point	NOUN
admet-1476	123	18	interval	interval	NOUN
admet-1476	123	19	and	and	CCONJ
admet-1476	123	20	2.21	2.21	NUM
admet-1476	123	21	at	at	ADP
admet-1476	123	22	later	later	ADJ
admet-1476	123	23	time	time	NOUN
admet-1476	123	24	point	point	NOUN
admet-1476	123	25	interval	interval	NOUN
admet-1476	123	26	(	(	PUNCT
admet-1476	123	27	figure	figure	NOUN
admet-1476	123	28	s1	s1	NOUN
admet-1476	123	29	;	;	PUNCT
admet-1476	123	30	supporting	support	VERB
admet-1476	123	31	information	information	NOUN
admet-1476	123	32	)	)	PUNCT
admet-1476	123	33	.	.	PUNCT
admet-1476	124	1	both	both	PRON
admet-1476	124	2	,	,	PUNCT
admet-1476	124	3	the	the	DET
admet-1476	124	4	solubility	solubility	NOUN
admet-1476	124	5	ratio	ratio	NOUN
admet-1476	124	6	,	,	PUNCT
admet-1476	124	7	and	and	CCONJ
admet-1476	124	8	the	the	DET
admet-1476	124	9	flux	flux	NOUN
admet-1476	124	10	ratio	ratio	NOUN
admet-1476	124	11	indicated	indicate	VERB
admet-1476	124	12	a	a	DET
admet-1476	124	13	positive	positive	ADJ
admet-1476	124	14	food	food	NOUN
admet-1476	124	15	effect	effect	NOUN
admet-1476	124	16	.	.	PUNCT
admet-1476	125	1	the	the	DET
admet-1476	125	2	ratio	ratio	NOUN
admet-1476	125	3	of	of	ADP
admet-1476	125	4	means	mean	NOUN
admet-1476	125	5	of	of	ADP
admet-1476	125	6	auc	auc	NOUN
admet-1476	125	7	and	and	CCONJ
admet-1476	125	8	cmax	cmax	NOUN
admet-1476	125	9	between	between	ADP
admet-1476	125	10	the	the	DET
admet-1476	125	11	fed	fed	PROPN
admet-1476	125	12	and	and	CCONJ
admet-1476	125	13	fasted	fast	VERB
admet-1476	125	14	state	state	NOUN
admet-1476	125	15	was	be	AUX
admet-1476	125	16	calculated	calculate	VERB
admet-1476	125	17	to	to	PART
admet-1476	125	18	be	be	AUX
admet-1476	125	19	2.36	2.36	NUM
admet-1476	125	20	and	and	CCONJ
admet-1476	125	21	3.68	3.68	NUM
admet-1476	125	22	respectively	respectively	ADV
admet-1476	125	23	and	and	CCONJ
admet-1476	125	24	confirmed	confirm	VERB
admet-1476	125	25	the	the	DET
admet-1476	125	26	positive	positive	ADJ
admet-1476	125	27	food	food	NOUN
admet-1476	125	28	effect	effect	NOUN
admet-1476	125	29	[	[	X
admet-1476	125	30	27	27	NUM
admet-1476	125	31	]	]	PUNCT
admet-1476	125	32	.	.	PUNCT
admet-1476	126	1	the	the	DET
admet-1476	126	2	drug	drug	NOUN
admet-1476	126	3	was	be	AUX
admet-1476	126	4	reported	report	VERB
admet-1476	126	5	to	to	PART
admet-1476	126	6	be	be	AUX
admet-1476	126	7	released	release	VERB
admet-1476	126	8	completely	completely	ADV
admet-1476	126	9	and	and	CCONJ
admet-1476	126	10	rapidly	rapidly	ADV
admet-1476	126	11	from	from	ADP
admet-1476	126	12	the	the	DET
admet-1476	126	13	formulation	formulation	NOUN
admet-1476	126	14	in	in	ADP
admet-1476	126	15	the	the	DET
admet-1476	126	16	fed	fed	PROPN
admet-1476	126	17	state	state	NOUN
admet-1476	126	18	compared	compare	VERB
admet-1476	126	19	to	to	ADP
admet-1476	126	20	the	the	DET
admet-1476	126	21	fasted	fast	VERB
admet-1476	126	22	conditions	condition	NOUN
admet-1476	126	23	,	,	PUNCT
admet-1476	126	24	thereby	thereby	ADV
admet-1476	126	25	reducing	reduce	VERB
admet-1476	126	26	the	the	DET
admet-1476	126	27	tmax	tmax	ADJ
admet-1476	126	28	value	value	NOUN
admet-1476	126	29	from	from	ADP
admet-1476	126	30	7.1	7.1	NUM
admet-1476	126	31	to	to	ADP
admet-1476	126	32	4.5	4.5	NUM
admet-1476	126	33	hours	hour	NOUN
admet-1476	127	1	[	[	X
admet-1476	127	2	27	27	NUM
admet-1476	127	3	]	]	PUNCT
admet-1476	127	4	.	.	PUNCT
admet-1476	128	1	an	an	DET
admet-1476	128	2	increased	increase	VERB
admet-1476	128	3	bile	bile	NOUN
admet-1476	128	4	salt	salt	NOUN
admet-1476	128	5	and	and	CCONJ
admet-1476	128	6	lecithin	lecithin	NOUN
admet-1476	128	7	production	production	NOUN
admet-1476	128	8	in	in	ADP
admet-1476	128	9	the	the	DET
admet-1476	128	10	fed	fed	PROPN
admet-1476	128	11	state	state	NOUN
admet-1476	128	12	is	be	AUX
admet-1476	128	13	reported	report	VERB
admet-1476	128	14	to	to	PART
admet-1476	128	15	help	help	VERB
admet-1476	128	16	in	in	ADP
admet-1476	128	17	solubilization	solubilization	NOUN
admet-1476	128	18	of	of	ADP
admet-1476	128	19	poorly	poorly	ADV
admet-1476	128	20	soluble	soluble	ADJ
admet-1476	128	21	drugs	drug	NOUN
admet-1476	128	22	[	[	X
admet-1476	128	23	28	28	NUM
admet-1476	128	24	]	]	PUNCT
admet-1476	128	25	.	.	PUNCT
admet-1476	129	1	amiodarone	amiodarone	PROPN
admet-1476	129	2	has	have	VERB
admet-1476	129	3	high	high	ADJ
admet-1476	129	4	log	log	NOUN
admet-1476	129	5	p	p	NOUN
admet-1476	129	6	value	value	NOUN
admet-1476	129	7	of	of	ADP
admet-1476	129	8	7.80	7.80	NUM
admet-1476	129	9	and	and	CCONJ
admet-1476	129	10	is	be	AUX
admet-1476	129	11	believed	believe	VERB
admet-1476	129	12	to	to	PART
admet-1476	129	13	undergo	undergo	VERB
admet-1476	129	14	micellar	micellar	NOUN
admet-1476	129	15	solubilized	solubilize	VERB
admet-1476	129	16	in	in	ADP
admet-1476	129	17	the	the	DET
admet-1476	129	18	fed	fed	PROPN
admet-1476	129	19	state	state	NOUN
admet-1476	130	1	[	[	X
admet-1476	130	2	27	27	NUM
admet-1476	130	3	]	]	PUNCT
admet-1476	130	4	,	,	PUNCT
admet-1476	130	5	that	that	PRON
admet-1476	130	6	resulted	result	VERB
admet-1476	130	7	in	in	ADP
admet-1476	130	8	an	an	DET
admet-1476	130	9	increased	increase	VERB
admet-1476	130	10	exposure	exposure	NOUN
admet-1476	130	11	.	.	PUNCT
admet-1476	131	1	on	on	ADP
admet-1476	131	2	similar	similar	ADJ
admet-1476	131	3	lines	line	NOUN
admet-1476	131	4	three	three	NUM
admet-1476	131	5	other	other	ADJ
admet-1476	131	6	bcs	bc	NOUN
admet-1476	131	7	–	–	PUNCT
admet-1476	131	8	ii	ii	NOUN
admet-1476	131	9	drugs	drug	NOUN
admet-1476	131	10	,	,	PUNCT
admet-1476	131	11	celecoxib	celecoxib	VERB
admet-1476	131	12	[	[	X
admet-1476	131	13	29	29	NUM
admet-1476	131	14	]	]	PUNCT
admet-1476	131	15	,	,	PUNCT
admet-1476	131	16	danazol	danazol	VERB
admet-1476	132	1	[	[	X
admet-1476	132	2	30	30	NUM
admet-1476	132	3	]	]	PUNCT
admet-1476	132	4	,	,	PUNCT
admet-1476	132	5	and	and	CCONJ
admet-1476	132	6	griseofulvin	griseofulvin	NOUN
admet-1476	132	7	[	[	X
admet-1476	132	8	31	31	NUM
admet-1476	132	9	]	]	PUNCT
admet-1476	132	10	exhibited	exhibit	VERB
admet-1476	132	11	positive	positive	ADJ
admet-1476	132	12	food	food	NOUN
admet-1476	132	13	effect	effect	NOUN
admet-1476	132	14	in	in	ADP
admet-1476	132	15	the	the	DET
admet-1476	132	16	clinic	clinic	NOUN
admet-1476	132	17	and	and	CCONJ
admet-1476	132	18	same	same	ADJ
admet-1476	132	19	was	be	AUX
admet-1476	132	20	predicted	predict	VERB
admet-1476	132	21	by	by	ADP
admet-1476	132	22	the	the	DET
admet-1476	132	23	solubility	solubility	NOUN
admet-1476	132	24	and	and	CCONJ
admet-1476	132	25	the	the	DET
admet-1476	132	26	flux	flux	NOUN
admet-1476	132	27	ratio	ratio	NOUN
admet-1476	132	28	between	between	ADP
admet-1476	132	29	fessif	fessif	NOUN
admet-1476	132	30	and	and	CCONJ
admet-1476	132	31	fassif	fassif	NOUN
admet-1476	132	32	(	(	PUNCT
admet-1476	132	33	table	table	NOUN
admet-1476	132	34	3	3	NUM
admet-1476	132	35	;	;	PUNCT
admet-1476	132	36	figure	figure	NOUN
admet-1476	132	37	s2	s2	PROPN
admet-1476	132	38	,	,	PUNCT
admet-1476	132	39	s3	s3	PROPN
admet-1476	132	40	,	,	PUNCT
admet-1476	132	41	s4	s4	PROPN
admet-1476	132	42	;	;	PUNCT
admet-1476	132	43	supporting	support	VERB
admet-1476	132	44	information	information	NOUN
admet-1476	132	45	)	)	PUNCT
admet-1476	132	46	.	.	PUNCT
admet-1476	133	1	figure	figure	NOUN
admet-1476	133	2	1	1	NUM
admet-1476	133	3	.	.	PUNCT
admet-1476	133	4	furosemide	furosemide	PROPN
admet-1476	133	5	admet	admet	PROPN
admet-1476	133	6	&	&	CCONJ
admet-1476	133	7	dmpk	dmpk	PROPN
admet-1476	133	8	10(4	10(4	NUM
admet-1476	133	9	)	)	PUNCT
admet-1476	133	10	(	(	PUNCT
admet-1476	133	11	2022	2022	NUM
admet-1476	133	12	)	)	PUNCT
admet-1476	133	13	299	299	NUM
admet-1476	133	14	-	-	SYM
admet-1476	133	15	314	314	NUM
admet-1476	133	16	material	material	NOUN
admet-1476	133	17	sparing	sparing	NOUN
admet-1476	133	18	µflux	µflux	NOUN
admet-1476	133	19	methodology	methodology	NOUN
admet-1476	133	20	doi	doi	NOUN
admet-1476	133	21	:	:	PUNCT
admet-1476	133	22	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	NOUN
admet-1476	133	23	305	305	NUM
admet-1476	133	24	table	table	NOUN
admet-1476	133	25	3	3	NUM
admet-1476	133	26	.	.	PUNCT
admet-1476	133	27	physicochemical	physicochemical	ADJ
admet-1476	133	28	properties	property	NOUN
admet-1476	133	29	,	,	PUNCT
admet-1476	133	30	food	food	NOUN
admet-1476	133	31	effect	effect	NOUN
admet-1476	133	32	data	datum	NOUN
admet-1476	133	33	and	and	CCONJ
admet-1476	133	34	measured	measure	VERB
admet-1476	133	35	flux	flux	NOUN
admet-1476	133	36	of	of	ADP
admet-1476	133	37	the	the	DET
admet-1476	133	38	studied	study	VERB
admet-1476	133	39	compounds	compound	VERB
admet-1476	133	40	drugs	drug	NOUN
admet-1476	133	41	bcs	bcs	NOUN
admet-1476	133	42	class	class	NOUN
admet-1476	133	43	log	log	NOUN
admet-1476	133	44	p	p	NOUN
admet-1476	133	45	solubility	solubility	NOUN
admet-1476	133	46	ratio	ratio	NOUN
admet-1476	133	47	observed	observe	VERB
admet-1476	133	48	auc	auc	NOUN
admet-1476	133	49	ratio	ratio	NOUN
admet-1476	133	50	observed	observe	VERB
admet-1476	133	51	cmax	cmax	NOUN
admet-1476	133	52	ratio	ratio	PROPN
admet-1476	133	53	fe	fe	X
admet-1476	133	54	dose	dose	PROPN
admet-1476	133	55	used	use	VERB
admet-1476	133	56	in	in	ADP
admet-1476	133	57	clinical	clinical	ADJ
admet-1476	133	58	data	datum	NOUN
admet-1476	133	59	dose	dose	VERB
admet-1476	133	60	used	use	VERB
admet-1476	133	61	flux	flux	PROPN
admet-1476	133	62	study	study	PROPN
admet-1476	133	63	flux	flux	PROPN
admet-1476	133	64	fe	fe	PROPN
admet-1476	133	65	(	(	PUNCT
admet-1476	133	66	±sd	±sd	NOUN
admet-1476	133	67	;	;	PUNCT
admet-1476	133	68	n=3	n=3	NUM
admet-1476	133	69	)	)	PUNCT
admet-1476	133	70	flux	flux	NOUN
admet-1476	133	71	fa	fa	PROPN
admet-1476	133	72	(	(	PUNCT
admet-1476	133	73	±sd	±sd	NOUN
admet-1476	133	74	;	;	PUNCT
admet-1476	133	75	n=3	n=3	NUM
admet-1476	133	76	)	)	PUNCT
admet-1476	133	77	flux	flux	NOUN
admet-1476	133	78	ratios	ratio	NOUN
admet-1476	133	79	(	(	PUNCT
admet-1476	133	80	fed	feed	VERB
admet-1476	133	81	/	/	SYM
admet-1476	133	82	fasted	fast	VERB
admet-1476	133	83	)	)	PUNCT
admet-1476	133	84	(	(	PUNCT
admet-1476	133	85	fed	feed	VERB
admet-1476	133	86	/	/	SYM
admet-1476	133	87	fasted	fast	VERB
admet-1476	133	88	)	)	PUNCT
admet-1476	133	89	(	(	PUNCT
admet-1476	133	90	fed	feed	VERB
admet-1476	133	91	/	/	SYM
admet-1476	133	92	fasted	fast	VERB
admet-1476	133	93	)	)	PUNCT
admet-1476	133	94	(	(	PUNCT
admet-1476	133	95	mg	mg	X
admet-1476	133	96	)	)	PUNCT
admet-1476	133	97	(	(	PUNCT
admet-1476	133	98	mg	mg	X
admet-1476	133	99	)	)	PUNCT
admet-1476	133	100	(	(	PUNCT
admet-1476	133	101	fed	feed	VERB
admet-1476	133	102	/	/	SYM
admet-1476	133	103	fasted	fast	VERB
admet-1476	133	104	)	)	PUNCT
admet-1476	134	1	amiodarone	amiodarone	PROPN
admet-1476	135	1	[	[	X
admet-1476	135	2	27	27	NUM
admet-1476	135	3	]	]	PUNCT
admet-1476	135	4	(	(	PUNCT
admet-1476	135	5	early)1	early)1	PROPN
admet-1476	135	6	ii	ii	PROPN
admet-1476	135	7	7.8	7.8	NUM
admet-1476	135	8	2.23	2.23	NUM
admet-1476	135	9	2.36	2.36	NUM
admet-1476	135	10	3.68	3.68	NUM
admet-1476	135	11	positive	positive	ADJ
admet-1476	135	12	600	600	NUM
admet-1476	135	13	200	200	NUM
admet-1476	135	14	0.073	0.073	NUM
admet-1476	135	15	±	±	NUM
admet-1476	135	16	0.001	0.001	NUM
admet-1476	135	17	0.017±	0.017±	NUM
admet-1476	136	1	0.003	0.003	NUM
admet-1476	136	2	4.25	4.25	NUM
admet-1476	136	3	amiodarone	amiodarone	NOUN
admet-1476	136	4	(	(	PUNCT
admet-1476	136	5	late)2	late)2	PROPN
admet-1476	136	6	ii	ii	PROPN
admet-1476	136	7	7.8	7.8	NUM
admet-1476	136	8	2.23	2.23	NUM
admet-1476	136	9	2.36	2.36	NUM
admet-1476	136	10	3.68	3.68	NUM
admet-1476	136	11	positive	positive	ADJ
admet-1476	136	12	600	600	NUM
admet-1476	136	13	200	200	NUM
admet-1476	136	14	1.277±	1.277±	NUM
admet-1476	136	15	0.109	0.109	NUM
admet-1476	136	16	0.579	0.579	NUM
admet-1476	136	17	±	±	NUM
admet-1476	136	18	0.095	0.095	NUM
admet-1476	136	19	2.21	2.21	NUM
admet-1476	136	20	celecoxib	celecoxib	NOUN
admet-1476	137	1	[	[	X
admet-1476	137	2	29	29	NUM
admet-1476	137	3	]	]	SYM
admet-1476	137	4	ii	ii	NOUN
admet-1476	137	5	3.02	3.02	NUM
admet-1476	137	6	2.24	2.24	NUM
admet-1476	137	7	1.19	1.19	NUM
admet-1476	137	8	1.29	1.29	NUM
admet-1476	137	9	positive	positive	ADJ
admet-1476	137	10	200	200	NUM
admet-1476	137	11	50	50	NUM
admet-1476	137	12	0.632	0.632	NUM
admet-1476	137	13	±	±	NUM
admet-1476	137	14	0.077	0.077	NUM
admet-1476	137	15	0.186	0.186	NUM
admet-1476	137	16	±	±	NUM
admet-1476	137	17	0.021	0.021	NUM
admet-1476	137	18	3.4	3.4	NUM
admet-1476	137	19	clopidogrel	clopidogrel	NOUN
admet-1476	137	20	bisulfate	bisulfate	VERB
admet-1476	137	21	[	[	X
admet-1476	137	22	43	43	NUM
admet-1476	137	23	]	]	SYM
admet-1476	137	24	ii	ii	PROPN
admet-1476	137	25	/	/	SYM
admet-1476	137	26	iv	iv	NUM
admet-1476	137	27	4.2	4.2	NUM
admet-1476	137	28	3.85	3.85	NUM
admet-1476	137	29	1.02	1.02	NUM
admet-1476	137	30	0.79	0.79	NUM
admet-1476	137	31	none	none	NOUN
admet-1476	137	32	75	75	NUM
admet-1476	137	33	75	75	NUM
admet-1476	137	34	2.168	2.168	NUM
admet-1476	137	35	±	±	NUM
admet-1476	137	36	0.323	0.323	NUM
admet-1476	137	37	1.751	1.751	NUM
admet-1476	137	38	±	±	NUM
admet-1476	137	39	0.540	0.540	NUM
admet-1476	137	40	1.24	1.24	NUM
admet-1476	137	41	danazol	danazol	ADJ
admet-1476	137	42	[	[	X
admet-1476	137	43	30	30	NUM
admet-1476	137	44	]	]	PUNCT
admet-1476	137	45	ii	ii	NOUN
admet-1476	137	46	4.7	4.7	NUM
admet-1476	137	47	3.43	3.43	NUM
admet-1476	137	48	3.13	3.13	NUM
admet-1476	137	49	2.73	2.73	NUM
admet-1476	137	50	positive	positive	ADJ
admet-1476	137	51	100	100	NUM
admet-1476	137	52	100	100	NUM
admet-1476	137	53	0.352	0.352	NUM
admet-1476	137	54	±	±	NUM
admet-1476	137	55	0.063	0.063	NUM
admet-1476	137	56	0.081	0.081	NUM
admet-1476	137	57	±	±	NUM
admet-1476	137	58	0.016	0.016	NUM
admet-1476	137	59	4.35	4.35	NUM
admet-1476	137	60	fluoxetine	fluoxetine	NOUN
admet-1476	137	61	hcl	hcl	PROPN
admet-1476	138	1	[	[	X
admet-1476	138	2	41	41	NUM
admet-1476	138	3	]	]	X
admet-1476	138	4	i	i	PRON
admet-1476	138	5	4.5	4.5	NUM
admet-1476	138	6	1.17	1.17	NUM
admet-1476	138	7	0.96	0.96	NUM
admet-1476	138	8	0.85	0.85	NUM
admet-1476	139	1	none	none	NOUN
admet-1476	139	2	40	40	NUM
admet-1476	139	3	40	40	NUM
admet-1476	139	4	0.85	0.85	NUM
admet-1476	139	5	±	±	NUM
admet-1476	139	6	0.01	0.01	NUM
admet-1476	139	7	1.77	1.77	NUM
admet-1476	139	8	±	±	NUM
admet-1476	139	9	0.15	0.15	NUM
admet-1476	139	10	0.5	0.5	NUM
admet-1476	139	11	furosemide	furosemide	ADV
admet-1476	139	12	[	[	X
admet-1476	139	13	32	32	NUM
admet-1476	139	14	]	]	PUNCT
admet-1476	139	15	iv	iv	NUM
admet-1476	139	16	2.56	2.56	NUM
admet-1476	139	17	0.23	0.23	NUM
admet-1476	139	18	1.18	1.18	NUM
admet-1476	139	19	0.67	0.67	NUM
admet-1476	139	20	negative	negative	ADJ
admet-1476	139	21	40	40	NUM
admet-1476	139	22	80	80	NUM
admet-1476	139	23	0.208	0.208	NUM
admet-1476	139	24	±	±	NUM
admet-1476	139	25	0.036	0.036	NUM
admet-1476	139	26	0.018	0.018	NUM
admet-1476	139	27	±	±	NUM
admet-1476	139	28	0.003	0.003	NUM
admet-1476	139	29	11.48	11.48	NUM
admet-1476	139	30	griseofulvin	griseofulvin	NOUN
admet-1476	139	31	[	[	X
admet-1476	139	32	31	31	NUM
admet-1476	139	33	]	]	PUNCT
admet-1476	139	34	ii	ii	NOUN
admet-1476	139	35	2.2	2.2	NUM
admet-1476	139	36	1.24	1.24	NUM
admet-1476	139	37	1.7	1.7	NUM
admet-1476	139	38	2.2	2.2	NUM
admet-1476	139	39	(	(	PUNCT
admet-1476	139	40	4	4	NUM
admet-1476	139	41	h	h	NOUN
admet-1476	139	42	)	)	PUNCT
admet-1476	139	43	1.7	1.7	NUM
admet-1476	139	44	(	(	PUNCT
admet-1476	139	45	8	8	NUM
admet-1476	139	46	h	h	NOUN
admet-1476	139	47	)	)	PUNCT
admet-1476	139	48	positive	positive	ADJ
admet-1476	139	49	1000	1000	NUM
admet-1476	139	50	125	125	NUM
admet-1476	139	51	0.218	0.218	NUM
admet-1476	139	52	±	±	NUM
admet-1476	139	53	0.009	0.009	NUM
admet-1476	139	54	0.205	0.205	NUM
admet-1476	139	55	±	±	NUM
admet-1476	139	56	0.011	0.011	NUM
admet-1476	139	57	1.06	1.06	NUM
admet-1476	139	58	isoniazid	isoniazid	NOUN
admet-1476	139	59	[	[	X
admet-1476	139	60	37	37	NUM
admet-1476	139	61	]	]	X
admet-1476	139	62	i	i	PRON
admet-1476	139	63	-0.52	-0.52	PROPN
admet-1476	139	64	n	n	X
admet-1476	139	65	/	/	SYM
admet-1476	139	66	a	a	DET
admet-1476	139	67	0.88	0.88	NUM
admet-1476	139	68	0.49	0.49	NUM
admet-1476	139	69	negative	negative	ADJ
admet-1476	139	70	300	300	NUM
admet-1476	139	71	300	300	NUM
admet-1476	139	72	0.020	0.020	NUM
admet-1476	139	73	±	±	NUM
admet-1476	139	74	0	0	NUM
admet-1476	139	75	0.020	0.020	NUM
admet-1476	139	76	±	±	NUM
admet-1476	139	77	0	0	NUM
admet-1476	139	78	1.02/0.92	1.02/0.92	NUM
admet-1476	139	79	nefazodone	nefazodone	NOUN
admet-1476	139	80	hcl	hcl	PROPN
admet-1476	140	1	[	[	X
admet-1476	140	2	38	38	NUM
admet-1476	140	3	]	]	SYM
admet-1476	140	4	ii	ii	PROPN
admet-1476	140	5	3.5	3.5	NUM
admet-1476	140	6	1.52	1.52	NUM
admet-1476	140	7	0.78	0.78	NUM
admet-1476	140	8	0.93	0.93	NUM
admet-1476	140	9	negative	negative	ADJ
admet-1476	140	10	200	200	NUM
admet-1476	140	11	50	50	NUM
admet-1476	140	12	1.077	1.077	NUM
admet-1476	140	13	±	±	NUM
admet-1476	140	14	0.084	0.084	NUM
admet-1476	140	15	0.521	0.521	NUM
admet-1476	140	16	±	±	NUM
admet-1476	140	17	0.179	0.179	NUM
admet-1476	140	18	2.07	2.07	NUM
admet-1476	140	19	nefazodone	nefazodone	NOUN
admet-1476	140	20	hcl	hcl	PROPN
admet-1476	140	21	suspension	suspension	PROPN
admet-1476	140	22	ii	ii	PROPN
admet-1476	140	23	3.5	3.5	NUM
admet-1476	140	24	1.52	1.52	NUM
admet-1476	140	25	0.78	0.78	NUM
admet-1476	140	26	0.93	0.93	NUM
admet-1476	140	27	negative	negative	ADJ
admet-1476	140	28	200	200	NUM
admet-1476	140	29	100	100	NUM
admet-1476	140	30	1.923	1.923	NUM
admet-1476	140	31	±	±	NUM
admet-1476	140	32	0.547	0.547	NUM
admet-1476	140	33	2.610	2.610	NUM
admet-1476	140	34	±	±	NUM
admet-1476	140	35	0.618	0.618	NUM
admet-1476	140	36	0.74	0.74	NUM
admet-1476	140	37	nifedipine	nifedipine	NOUN
admet-1476	140	38	[	[	X
admet-1476	140	39	44	44	NUM
admet-1476	140	40	]	]	SYM
admet-1476	140	41	ii	ii	NOUN
admet-1476	140	42	3.17	3.17	NUM
admet-1476	140	43	3.2	3.2	NUM
admet-1476	140	44	1.02	1.02	NUM
admet-1476	140	45	0.74	0.74	NUM
admet-1476	140	46	none	none	NOUN
admet-1476	140	47	10	10	NUM
admet-1476	140	48	25	25	NUM
admet-1476	140	49	0.235	0.235	NUM
admet-1476	140	50	±	±	NUM
admet-1476	140	51	0.028	0.028	NUM
admet-1476	140	52	0.233	0.233	NUM
admet-1476	140	53	±	±	NOUN
admet-1476	140	54	0.073	0.073	NUM
admet-1476	140	55	1.01	1.01	NUM
admet-1476	140	56	zidovudine	zidovudine	NOUN
admet-1476	141	1	[	[	X
admet-1476	141	2	42	42	NUM
admet-1476	141	3	]	]	X
admet-1476	141	4	iii	iii	X
admet-1476	141	5	0.13	0.13	NUM
admet-1476	141	6	n	n	CCONJ
admet-1476	141	7	/	/	SYM
admet-1476	141	8	a	a	DET
admet-1476	141	9	0.9	0.9	NUM
admet-1476	141	10	0.3	0.3	NUM
admet-1476	141	11	negative	negative	ADJ
admet-1476	141	12	100	100	NUM
admet-1476	141	13	200	200	NUM
admet-1476	141	14	0.034	0.034	NUM
admet-1476	141	15	±	±	NUM
admet-1476	141	16	0.002	0.002	NUM
admet-1476	141	17	0.037	0.037	NUM
admet-1476	141	18	±	±	NUM
admet-1476	141	19	0.007	0.007	NUM
admet-1476	141	20	0.92	0.92	NUM
admet-1476	141	21	1	1	NUM
admet-1476	141	22	“	"	PUNCT
admet-1476	141	23	early	early	ADJ
admet-1476	141	24	”	"	PUNCT
admet-1476	141	25	flux	flux	NOUN
admet-1476	141	26	refers	refer	VERB
admet-1476	141	27	to	to	ADP
admet-1476	141	28	the	the	DET
admet-1476	141	29	initial	initial	ADJ
admet-1476	141	30	appearance	appearance	NOUN
admet-1476	141	31	rate	rate	NOUN
admet-1476	141	32	in	in	ADP
admet-1476	141	33	the	the	DET
admet-1476	141	34	acceptors	acceptor	NOUN
admet-1476	141	35	.	.	PUNCT
admet-1476	142	1	the	the	DET
admet-1476	142	2	early	early	ADJ
admet-1476	142	3	flux	flux	NOUN
admet-1476	142	4	was	be	AUX
admet-1476	142	5	calculated	calculate	VERB
admet-1476	142	6	using	use	VERB
admet-1476	142	7	the	the	DET
admet-1476	142	8	data	datum	NOUN
admet-1476	142	9	in	in	ADP
admet-1476	142	10	the	the	DET
admet-1476	142	11	first	first	ADJ
admet-1476	142	12	2	2	NUM
admet-1476	142	13	hours	hour	NOUN
admet-1476	142	14	of	of	ADP
admet-1476	142	15	the	the	DET
admet-1476	142	16	experiment	experiment	NOUN
admet-1476	142	17	,	,	PUNCT
admet-1476	142	18	selecting	select	VERB
admet-1476	142	19	time	time	NOUN
admet-1476	142	20	interval	interval	NOUN
admet-1476	142	21	for	for	ADP
admet-1476	142	22	each	each	DET
admet-1476	142	23	media	medium	NOUN
admet-1476	142	24	excluding	exclude	VERB
admet-1476	142	25	lag	lag	NOUN
admet-1476	142	26	time	time	NOUN
admet-1476	142	27	.	.	PUNCT
admet-1476	143	1	2	2	NUM
admet-1476	143	2	“	"	PUNCT
admet-1476	143	3	late	late	ADJ
admet-1476	143	4	”	"	PUNCT
admet-1476	143	5	flux	flux	NOUN
admet-1476	143	6	corresponds	correspond	VERB
admet-1476	143	7	to	to	ADP
admet-1476	143	8	the	the	DET
admet-1476	143	9	appearance	appearance	NOUN
admet-1476	143	10	rate	rate	NOUN
admet-1476	143	11	during	during	ADP
admet-1476	143	12	the	the	DET
admet-1476	143	13	later	later	ADJ
admet-1476	143	14	time	time	NOUN
admet-1476	143	15	points	point	VERB
admet-1476	143	16	in	in	ADP
admet-1476	143	17	the	the	DET
admet-1476	143	18	acceptor	acceptor	NOUN
admet-1476	143	19	.	.	PUNCT
admet-1476	144	1	the	the	DET
admet-1476	144	2	late	late	ADJ
admet-1476	144	3	flux	flux	NOUN
admet-1476	144	4	was	be	AUX
admet-1476	144	5	calculated	calculate	VERB
admet-1476	144	6	using	use	VERB
admet-1476	144	7	the	the	DET
admet-1476	144	8	data	datum	NOUN
admet-1476	144	9	in	in	ADP
admet-1476	144	10	the	the	DET
admet-1476	144	11	2.5	2.5	NUM
admet-1476	144	12	-	-	SYM
admet-1476	144	13	9	9	NUM
admet-1476	144	14	hours	hour	NOUN
admet-1476	144	15	’	'	PUNCT
admet-1476	144	16	time	time	NOUN
admet-1476	144	17	interval	interval	NOUN
admet-1476	144	18	,	,	PUNCT
admet-1476	144	19	selecting	select	VERB
admet-1476	144	20	the	the	DET
admet-1476	144	21	intervals	interval	NOUN
admet-1476	144	22	guided	guide	VERB
admet-1476	144	23	by	by	ADP
admet-1476	144	24	linearity	linearity	NOUN
admet-1476	144	25	of	of	ADP
admet-1476	144	26	the	the	DET
admet-1476	144	27	concentration	concentration	NOUN
admet-1476	144	28	-	-	PUNCT
admet-1476	144	29	time	time	NOUN
admet-1476	144	30	profiles	profile	NOUN
admet-1476	144	31	in	in	ADP
admet-1476	144	32	the	the	DET
admet-1476	144	33	receptor	receptor	NOUN
admet-1476	145	1	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	PRON
admet-1476	145	2	c.	c.	PROPN
admet-1476	145	3	jankovsky	jankovsky	PROPN
admet-1476	145	4	et	et	PROPN
admet-1476	145	5	al	al	PROPN
admet-1476	145	6	.	.	PROPN
admet-1476	145	7	admet	admet	PROPN
admet-1476	145	8	&	&	CCONJ
admet-1476	145	9	dmpk	dmpk	PROPN
admet-1476	145	10	10(4	10(4	NUM
admet-1476	145	11	)	)	PUNCT
admet-1476	145	12	(	(	PUNCT
admet-1476	145	13	2022	2022	NUM
admet-1476	145	14	)	)	PUNCT
admet-1476	145	15	299	299	NUM
admet-1476	145	16	-	-	SYM
admet-1476	145	17	314	314	NUM
admet-1476	145	18	306	306	NUM
admet-1476	145	19	furosemide	furosemide	NOUN
admet-1476	145	20	is	be	AUX
admet-1476	145	21	a	a	DET
admet-1476	145	22	bcs	bcs	NOUN
admet-1476	145	23	class	class	NOUN
admet-1476	145	24	iv	iv	NOUN
admet-1476	145	25	,	,	PUNCT
admet-1476	145	26	diprotic	diprotic	ADJ
admet-1476	145	27	weak	weak	ADJ
admet-1476	145	28	acid	acid	NOUN
admet-1476	145	29	with	with	ADP
admet-1476	145	30	pka	pka	PROPN
admet-1476	145	31	values	value	NOUN
admet-1476	145	32	at	at	ADP
admet-1476	145	33	3.53	3.53	NUM
admet-1476	145	34	(	(	PUNCT
admet-1476	145	35	-cooh	-cooh	PROPN
admet-1476	145	36	)	)	PUNCT
admet-1476	145	37	and	and	CCONJ
admet-1476	145	38	9.90	9.90	NUM
admet-1476	145	39	(	(	PUNCT
admet-1476	145	40	-so2nh2	-so2nh2	PROPN
admet-1476	145	41	)	)	PUNCT
admet-1476	145	42	(	(	PUNCT
admet-1476	145	43	figure	figure	NOUN
admet-1476	145	44	1	1	NUM
admet-1476	145	45	)	)	PUNCT
admet-1476	145	46	.	.	PUNCT
admet-1476	146	1	since	since	SCONJ
admet-1476	146	2	only	only	ADV
admet-1476	146	3	-cooh	-cooh	ADJ
admet-1476	146	4	group	group	NOUN
admet-1476	146	5	is	be	AUX
admet-1476	146	6	located	locate	VERB
admet-1476	146	7	within	within	ADP
admet-1476	146	8	the	the	DET
admet-1476	146	9	physiological	physiological	ADJ
admet-1476	146	10	ph	ph	NOUN
admet-1476	146	11	range	range	NOUN
admet-1476	146	12	,	,	PUNCT
admet-1476	146	13	the	the	DET
admet-1476	146	14	effect	effect	NOUN
admet-1476	146	15	of	of	ADP
admet-1476	146	16	the	the	DET
admet-1476	146	17	higher	high	ADJ
admet-1476	146	18	pka	pka	NOUN
admet-1476	146	19	(	(	PUNCT
admet-1476	146	20	9.90	9.90	NUM
admet-1476	146	21	)	)	PUNCT
admet-1476	146	22	on	on	ADP
admet-1476	146	23	ionization	ionization	NOUN
admet-1476	146	24	and	and	CCONJ
admet-1476	146	25	permeability	permeability	NOUN
admet-1476	146	26	-	-	PUNCT
admet-1476	146	27	solubility	solubility	NOUN
admet-1476	146	28	interplay	interplay	NOUN
admet-1476	146	29	of	of	ADP
admet-1476	146	30	furosemide	furosemide	NOUN
admet-1476	146	31	during	during	ADP
admet-1476	146	32	flux	flux	NOUN
admet-1476	146	33	experiments	experiment	NOUN
admet-1476	146	34	was	be	AUX
admet-1476	146	35	disregarded	disregard	VERB
admet-1476	146	36	for	for	ADP
admet-1476	146	37	the	the	DET
admet-1476	146	38	purposes	purpose	NOUN
admet-1476	146	39	of	of	ADP
admet-1476	146	40	this	this	DET
admet-1476	146	41	study	study	NOUN
admet-1476	146	42	.	.	PUNCT
admet-1476	147	1	the	the	DET
admet-1476	147	2	species	species	NOUN
admet-1476	147	3	distribution	distribution	NOUN
admet-1476	147	4	curve	curve	NOUN
admet-1476	147	5	[	[	X
admet-1476	147	6	25	25	NUM
admet-1476	147	7	]	]	PUNCT
admet-1476	147	8	indicates	indicate	VERB
admet-1476	147	9	that	that	SCONJ
admet-1476	147	10	the	the	DET
admet-1476	147	11	molecule	molecule	NOUN
admet-1476	147	12	is	be	AUX
admet-1476	147	13	fully	fully	ADV
admet-1476	147	14	protonated	protonate	VERB
admet-1476	147	15	at	at	ADP
admet-1476	147	16	ph	ph	PROPN
admet-1476	147	17	1.2	1.2	NUM
admet-1476	147	18	[	[	NOUN
admet-1476	147	19	ah2]0	ah2]0	X
admet-1476	147	20	and	and	CCONJ
admet-1476	147	21	reaches	reach	VERB
admet-1476	147	22	fully	fully	ADV
admet-1476	147	23	deprotonated	deprotonated	ADJ
admet-1476	147	24	state	state	NOUN
admet-1476	148	1	[	[	X
admet-1476	148	2	ah	ah	INTJ
admet-1476	148	3	]	]	PUNCT
admet-1476	148	4	at	at	ADP
admet-1476	148	5	ph	ph	PROPN
admet-1476	148	6	6.5	6.5	NUM
admet-1476	148	7	,	,	PUNCT
admet-1476	148	8	while	while	SCONJ
admet-1476	148	9	at	at	ADP
admet-1476	148	10	ph	ph	PROPN
admet-1476	148	11	5.0	5.0	NUM
admet-1476	148	12	only	only	ADV
admet-1476	148	13	~	~	PUNCT
admet-1476	148	14	97	97	NUM
admet-1476	148	15	%	%	NOUN
admet-1476	148	16	of	of	ADP
admet-1476	148	17	the	the	DET
admet-1476	148	18	drug	drug	NOUN
admet-1476	148	19	is	be	AUX
admet-1476	148	20	deprotonated	deprotonate	VERB
admet-1476	148	21	.	.	PUNCT
admet-1476	149	1	thus	thus	ADV
admet-1476	149	2	,	,	PUNCT
admet-1476	149	3	based	base	VERB
admet-1476	149	4	on	on	ADP
admet-1476	149	5	the	the	DET
admet-1476	149	6	henderson	henderson	PROPN
admet-1476	149	7	–	–	PUNCT
admet-1476	149	8	hasselbalch	hasselbalch	PROPN
admet-1476	149	9	equation	equation	NOUN
admet-1476	149	10	,	,	PUNCT
admet-1476	149	11	thermodynamic	thermodynamic	ADJ
admet-1476	149	12	solubility	solubility	NOUN
admet-1476	149	13	of	of	ADP
admet-1476	149	14	the	the	DET
admet-1476	149	15	drug	drug	NOUN
admet-1476	149	16	is	be	AUX
admet-1476	149	17	expected	expect	VERB
admet-1476	149	18	to	to	PART
admet-1476	149	19	be	be	AUX
admet-1476	149	20	lower	low	ADJ
admet-1476	149	21	at	at	ADP
admet-1476	149	22	ph	ph	ADJ
admet-1476	149	23	5.0	5.0	NUM
admet-1476	149	24	than	than	ADP
admet-1476	149	25	at	at	ADP
admet-1476	149	26	ph	ph	PROPN
admet-1476	149	27	6.5	6.5	NUM
admet-1476	149	28	.	.	PUNCT
admet-1476	150	1	the	the	DET
admet-1476	150	2	solubility	solubility	NOUN
admet-1476	150	3	ratio	ratio	NOUN
admet-1476	150	4	of	of	ADP
admet-1476	150	5	furosemide	furosemide	ADV
admet-1476	150	6	between	between	ADP
admet-1476	150	7	fessif	fessif	NOUN
admet-1476	150	8	(	(	PUNCT
admet-1476	150	9	684	684	NUM
admet-1476	150	10	µg	µg	NOUN
admet-1476	150	11	/	/	SYM
admet-1476	150	12	ml	ml	NOUN
admet-1476	150	13	)	)	PUNCT
admet-1476	150	14	and	and	CCONJ
admet-1476	150	15	fassif	fassif	NOUN
admet-1476	150	16	(	(	PUNCT
admet-1476	150	17	3201	3201	NUM
admet-1476	150	18	µg	µg	NOUN
admet-1476	150	19	/	/	SYM
admet-1476	150	20	ml	ml	NOUN
admet-1476	150	21	)	)	PUNCT
admet-1476	150	22	was	be	AUX
admet-1476	150	23	reported	report	VERB
admet-1476	150	24	to	to	PART
admet-1476	150	25	be	be	AUX
admet-1476	150	26	0.21	0.21	NUM
admet-1476	150	27	and	and	CCONJ
admet-1476	150	28	that	that	PRON
admet-1476	150	29	agrees	agree	VERB
admet-1476	150	30	with	with	ADP
admet-1476	150	31	the	the	DET
admet-1476	150	32	negative	negative	ADJ
admet-1476	150	33	food	food	NOUN
admet-1476	150	34	effect	effect	NOUN
admet-1476	150	35	reported	report	VERB
admet-1476	150	36	in	in	ADP
admet-1476	150	37	the	the	DET
admet-1476	150	38	clinic	clinic	NOUN
admet-1476	150	39	[	[	X
admet-1476	150	40	32	32	NUM
admet-1476	150	41	]	]	PUNCT
admet-1476	150	42	.	.	PUNCT
admet-1476	151	1	it	it	PRON
admet-1476	151	2	has	have	AUX
admet-1476	151	3	been	be	AUX
admet-1476	151	4	reported	report	VERB
admet-1476	151	5	that	that	SCONJ
admet-1476	151	6	the	the	DET
admet-1476	151	7	mucus	mucus	NOUN
admet-1476	151	8	layer	layer	NOUN
admet-1476	151	9	present	present	ADJ
admet-1476	151	10	at	at	ADP
admet-1476	151	11	the	the	DET
admet-1476	151	12	surface	surface	NOUN
admet-1476	151	13	of	of	ADP
admet-1476	151	14	the	the	DET
admet-1476	151	15	intestinal	intestinal	ADJ
admet-1476	151	16	lining	lining	NOUN
admet-1476	151	17	is	be	AUX
admet-1476	151	18	associated	associate	VERB
admet-1476	151	19	with	with	ADP
admet-1476	151	20	the	the	DET
admet-1476	151	21	lower	low	ADJ
admet-1476	151	22	microclimate	microclimate	NOUN
admet-1476	151	23	ph	ph	NOUN
admet-1476	151	24	than	than	ADP
admet-1476	151	25	that	that	PRON
admet-1476	151	26	of	of	ADP
admet-1476	151	27	bulk	bulk	ADJ
admet-1476	151	28	phase	phase	NOUN
admet-1476	151	29	in	in	ADP
admet-1476	151	30	the	the	DET
admet-1476	151	31	intestine	intestine	NOUN
admet-1476	151	32	.	.	PUNCT
admet-1476	152	1	the	the	DET
admet-1476	152	2	microclimate	microclimate	NOUN
admet-1476	152	3	ph	ph	NOUN
admet-1476	152	4	was	be	AUX
admet-1476	152	5	reported	report	VERB
admet-1476	152	6	to	to	PART
admet-1476	152	7	be	be	AUX
admet-1476	152	8	5.2	5.2	NUM
admet-1476	152	9	–	–	PUNCT
admet-1476	152	10	6.7	6.7	NUM
admet-1476	152	11	,	,	PUNCT
admet-1476	152	12	when	when	SCONJ
admet-1476	152	13	the	the	DET
admet-1476	152	14	bulk	bulk	ADJ
admet-1476	152	15	ph	ph	NOUN
admet-1476	152	16	was	be	AUX
admet-1476	152	17	7.2	7.2	NUM
admet-1476	152	18	[	[	X
admet-1476	152	19	33	33	NUM
admet-1476	152	20	]	]	PUNCT
admet-1476	152	21	.	.	PUNCT
admet-1476	153	1	as	as	ADP
admet-1476	153	2	per	per	ADP
admet-1476	153	3	the	the	DET
admet-1476	153	4	phpartition	phpartition	NOUN
admet-1476	153	5	hypothesis	hypothesis	NOUN
admet-1476	153	6	,	,	PUNCT
admet-1476	153	7	only	only	ADV
admet-1476	153	8	the	the	DET
admet-1476	153	9	uncharged	uncharged	ADJ
admet-1476	153	10	species	specie	NOUN
admet-1476	153	11	can	can	AUX
admet-1476	153	12	permeate	permeate	VERB
admet-1476	153	13	through	through	ADP
admet-1476	153	14	the	the	DET
admet-1476	153	15	lipophilic	lipophilic	ADJ
admet-1476	153	16	membranes	membrane	NOUN
admet-1476	153	17	,	,	PUNCT
admet-1476	153	18	thus	thus	ADV
admet-1476	153	19	it	it	PRON
admet-1476	153	20	is	be	AUX
admet-1476	153	21	expected	expect	VERB
admet-1476	153	22	,	,	PUNCT
admet-1476	153	23	that	that	DET
admet-1476	153	24	furosemide	furosemide	NOUN
admet-1476	153	25	has	have	VERB
admet-1476	153	26	higher	high	ADJ
admet-1476	153	27	membrane	membrane	NOUN
admet-1476	153	28	permeability	permeability	NOUN
admet-1476	153	29	at	at	ADP
admet-1476	153	30	ph	ph	PROPN
admet-1476	153	31	5.0	5.0	NUM
admet-1476	153	32	comparing	compare	VERB
admet-1476	153	33	to	to	ADP
admet-1476	153	34	ph	ph	PROPN
admet-1476	153	35	6.5	6.5	NUM
admet-1476	153	36	where	where	SCONJ
admet-1476	153	37	the	the	DET
admet-1476	153	38	drug	drug	NOUN
admet-1476	153	39	is	be	AUX
admet-1476	153	40	fully	fully	ADV
admet-1476	153	41	deprotonated	deprotonate	VERB
admet-1476	153	42	.	.	PUNCT
admet-1476	154	1	as	as	SCONJ
admet-1476	154	2	microclimate	microclimate	NOUN
admet-1476	154	3	ph	ph	NOUN
admet-1476	154	4	is	be	AUX
admet-1476	154	5	expected	expect	VERB
admet-1476	154	6	to	to	PART
admet-1476	154	7	be	be	AUX
admet-1476	154	8	constant	constant	ADJ
admet-1476	154	9	(	(	PUNCT
admet-1476	154	10	acidic	acidic	ADJ
admet-1476	154	11	than	than	ADP
admet-1476	154	12	the	the	DET
admet-1476	154	13	bulk	bulk	NOUN
admet-1476	154	14	ph	ph	NOUN
admet-1476	154	15	)	)	PUNCT
admet-1476	154	16	in	in	ADP
admet-1476	154	17	both	both	CCONJ
admet-1476	154	18	the	the	DET
admet-1476	154	19	fed	fed	PROPN
admet-1476	154	20	and	and	CCONJ
admet-1476	154	21	the	the	DET
admet-1476	154	22	fasting	fast	VERB
admet-1476	154	23	state	state	NOUN
admet-1476	155	1	[	[	X
admet-1476	155	2	33	33	NUM
admet-1476	155	3	]	]	PUNCT
admet-1476	155	4	,	,	PUNCT
admet-1476	155	5	the	the	DET
admet-1476	155	6	extent	extent	NOUN
admet-1476	155	7	of	of	ADP
admet-1476	155	8	furosemide	furosemide	ADJ
admet-1476	155	9	protonation	protonation	NOUN
admet-1476	155	10	and	and	CCONJ
admet-1476	155	11	hence	hence	ADV
admet-1476	155	12	the	the	DET
admet-1476	155	13	degree	degree	NOUN
admet-1476	155	14	of	of	ADP
admet-1476	155	15	the	the	DET
admet-1476	155	16	absorption	absorption	NOUN
admet-1476	155	17	flux	flux	NOUN
admet-1476	155	18	is	be	AUX
admet-1476	155	19	anticipated	anticipate	VERB
admet-1476	155	20	to	to	PART
admet-1476	155	21	be	be	AUX
admet-1476	155	22	same	same	ADJ
admet-1476	155	23	through	through	ADP
admet-1476	155	24	the	the	DET
admet-1476	155	25	lipophilic	lipophilic	ADJ
admet-1476	155	26	epithelial	epithelial	ADJ
admet-1476	155	27	membrane	membrane	NOUN
admet-1476	155	28	,	,	PUNCT
admet-1476	155	29	irrespective	irrespective	ADV
admet-1476	155	30	of	of	ADP
admet-1476	155	31	the	the	DET
admet-1476	155	32	prandial	prandial	ADJ
admet-1476	155	33	state	state	NOUN
admet-1476	155	34	.	.	PUNCT
admet-1476	156	1	this	this	PRON
admet-1476	156	2	is	be	AUX
admet-1476	156	3	evident	evident	ADJ
admet-1476	156	4	from	from	ADP
admet-1476	156	5	the	the	DET
admet-1476	156	6	clinical	clinical	ADJ
admet-1476	156	7	data	datum	NOUN
admet-1476	156	8	as	as	ADP
admet-1476	156	9	the	the	DET
admet-1476	156	10	auc	auc	NOUN
admet-1476	156	11	ratio	ratio	NOUN
admet-1476	156	12	(	(	PUNCT
admet-1476	156	13	fed	fed	PROPN
admet-1476	156	14	/	/	SYM
admet-1476	156	15	fasted	fast	VERB
admet-1476	156	16	)	)	PUNCT
admet-1476	156	17	was	be	AUX
admet-1476	156	18	reported	report	VERB
admet-1476	156	19	to	to	PART
admet-1476	156	20	be	be	AUX
admet-1476	156	21	1.18	1.18	NUM
admet-1476	156	22	(	(	PUNCT
admet-1476	156	23	table	table	NOUN
admet-1476	156	24	3	3	NUM
admet-1476	156	25	)	)	PUNCT
admet-1476	156	26	.	.	PUNCT
admet-1476	157	1	interestingly	interestingly	ADV
admet-1476	157	2	,	,	PUNCT
admet-1476	157	3	the	the	DET
admet-1476	157	4	negative	negative	ADJ
admet-1476	157	5	food	food	NOUN
admet-1476	157	6	effect	effect	NOUN
admet-1476	157	7	of	of	ADP
admet-1476	157	8	furosemide	furosemide	NOUN
admet-1476	157	9	was	be	AUX
admet-1476	157	10	based	base	VERB
admet-1476	157	11	on	on	ADP
admet-1476	157	12	the	the	DET
admet-1476	157	13	lower	low	ADJ
admet-1476	157	14	cmax	cmax	NOUN
admet-1476	157	15	value	value	NOUN
admet-1476	157	16	in	in	ADP
admet-1476	157	17	fed	fed	PROPN
admet-1476	157	18	state	state	NOUN
admet-1476	157	19	only	only	ADV
admet-1476	157	20	.	.	PUNCT
admet-1476	158	1	the	the	DET
admet-1476	158	2	lower	low	ADJ
admet-1476	158	3	cmax	cmax	NOUN
admet-1476	158	4	value	value	NOUN
admet-1476	158	5	in	in	ADP
admet-1476	158	6	fed	fed	PROPN
admet-1476	158	7	state	state	NOUN
admet-1476	158	8	might	might	AUX
admet-1476	158	9	be	be	AUX
admet-1476	158	10	due	due	ADJ
admet-1476	158	11	to	to	PART
admet-1476	158	12	delay	delay	VERB
admet-1476	158	13	in	in	ADP
admet-1476	158	14	the	the	DET
admet-1476	158	15	absorption	absorption	NOUN
admet-1476	158	16	,	,	PUNCT
admet-1476	158	17	possibly	possibly	ADV
admet-1476	158	18	due	due	ADP
admet-1476	158	19	to	to	ADP
admet-1476	158	20	an	an	DET
admet-1476	158	21	interaction	interaction	NOUN
admet-1476	158	22	/	/	SYM
admet-1476	158	23	complexation	complexation	NOUN
admet-1476	158	24	of	of	ADP
admet-1476	158	25	the	the	DET
admet-1476	158	26	drug	drug	NOUN
admet-1476	158	27	with	with	ADP
admet-1476	158	28	bile	bile	NOUN
admet-1476	158	29	salts	salt	NOUN
admet-1476	158	30	/	/	SYM
admet-1476	158	31	acids	acid	NOUN
admet-1476	158	32	.	.	PUNCT
admet-1476	159	1	interestingly	interestingly	ADV
admet-1476	159	2	,	,	PUNCT
admet-1476	159	3	the	the	DET
admet-1476	159	4	flux	flux	NOUN
admet-1476	159	5	ratio	ratio	NOUN
admet-1476	159	6	between	between	ADP
admet-1476	159	7	fessif	fessif	NOUN
admet-1476	159	8	and	and	CCONJ
admet-1476	159	9	fassif	fassif	NOUN
admet-1476	159	10	for	for	ADP
admet-1476	159	11	furosemide	furosemide	NOUN
admet-1476	159	12	was	be	AUX
admet-1476	159	13	determined	determine	VERB
admet-1476	159	14	to	to	PART
admet-1476	159	15	be	be	AUX
admet-1476	159	16	11.48	11.48	NUM
admet-1476	159	17	indicating	indicate	VERB
admet-1476	159	18	a	a	DET
admet-1476	159	19	positive	positive	ADJ
admet-1476	159	20	food	food	NOUN
admet-1476	159	21	effect	effect	NOUN
admet-1476	159	22	.	.	PUNCT
admet-1476	160	1	the	the	DET
admet-1476	160	2	food	food	NOUN
admet-1476	160	3	effect	effect	NOUN
admet-1476	160	4	prediction	prediction	NOUN
admet-1476	160	5	using	use	VERB
admet-1476	160	6	flux	flux	NOUN
admet-1476	160	7	ratio	ratio	NOUN
admet-1476	160	8	was	be	AUX
admet-1476	160	9	not	not	PART
admet-1476	160	10	in	in	ADP
admet-1476	160	11	agreement	agreement	NOUN
admet-1476	160	12	with	with	ADP
admet-1476	160	13	either	either	CCONJ
admet-1476	160	14	the	the	DET
admet-1476	160	15	solubility	solubility	NOUN
admet-1476	160	16	ratio	ratio	NOUN
admet-1476	160	17	or	or	CCONJ
admet-1476	160	18	with	with	ADP
admet-1476	160	19	the	the	DET
admet-1476	160	20	clinical	clinical	ADJ
admet-1476	160	21	results	result	NOUN
admet-1476	160	22	.	.	PUNCT
admet-1476	161	1	the	the	DET
admet-1476	161	2	solubility	solubility	NOUN
admet-1476	161	3	in	in	ADP
admet-1476	161	4	blank	blank	ADJ
admet-1476	161	5	fessif	fessif	NOUN
admet-1476	161	6	(	(	PUNCT
admet-1476	161	7	ph	ph	NOUN
admet-1476	161	8	5.0	5.0	NUM
admet-1476	161	9	)	)	PUNCT
admet-1476	161	10	,	,	PUNCT
admet-1476	161	11	and	and	CCONJ
admet-1476	161	12	blank	blank	ADJ
admet-1476	161	13	fassif	fassif	NOUN
admet-1476	161	14	(	(	PUNCT
admet-1476	161	15	ph	ph	NOUN
admet-1476	161	16	6.5	6.5	NUM
admet-1476	161	17	)	)	PUNCT
admet-1476	161	18	are	be	AUX
admet-1476	161	19	reported	report	VERB
admet-1476	161	20	to	to	PART
admet-1476	161	21	be	be	AUX
admet-1476	161	22	426	426	NUM
admet-1476	161	23	and	and	CCONJ
admet-1476	161	24	3017	3017	NUM
admet-1476	161	25	µg	µg	NOUN
admet-1476	161	26	/	/	SYM
admet-1476	161	27	ml	ml	X
admet-1476	161	28	respectively	respectively	ADV
admet-1476	161	29	[	[	X
admet-1476	161	30	25	25	NUM
admet-1476	161	31	]	]	PUNCT
admet-1476	161	32	.	.	PUNCT
admet-1476	162	1	the	the	DET
admet-1476	162	2	bile	bile	NOUN
admet-1476	162	3	salts	salt	NOUN
admet-1476	162	4	and	and	CCONJ
admet-1476	162	5	the	the	DET
admet-1476	162	6	lecithin	lecithin	NOUN
admet-1476	162	7	present	present	NOUN
admet-1476	162	8	in	in	ADP
admet-1476	162	9	the	the	DET
admet-1476	162	10	fessif	fessif	NOUN
admet-1476	162	11	and	and	CCONJ
admet-1476	162	12	fassif	fassif	NOUN
admet-1476	162	13	did	do	AUX
admet-1476	162	14	not	not	PART
admet-1476	162	15	improve	improve	VERB
admet-1476	162	16	the	the	DET
admet-1476	162	17	solubility	solubility	NOUN
admet-1476	162	18	of	of	ADP
admet-1476	162	19	the	the	DET
admet-1476	162	20	drug	drug	NOUN
admet-1476	162	21	,	,	PUNCT
admet-1476	162	22	possibly	possibly	ADV
admet-1476	162	23	due	due	ADP
admet-1476	162	24	to	to	ADP
admet-1476	162	25	the	the	DET
admet-1476	162	26	electrostatic	electrostatic	ADJ
admet-1476	162	27	repulsion	repulsion	NOUN
admet-1476	162	28	between	between	ADP
admet-1476	162	29	the	the	DET
admet-1476	162	30	furosemide	furosemide	ADJ
admet-1476	162	31	ion	ion	NOUN
admet-1476	162	32	and	and	CCONJ
admet-1476	162	33	the	the	DET
admet-1476	162	34	negative	negative	ADJ
admet-1476	162	35	charge	charge	NOUN
admet-1476	162	36	on	on	ADP
admet-1476	162	37	the	the	DET
admet-1476	162	38	taurocholate	taurocholate	NOUN
admet-1476	162	39	/	/	SYM
admet-1476	162	40	lecithin	lecithin	NOUN
admet-1476	162	41	micelles	micelle	NOUN
admet-1476	162	42	[	[	X
admet-1476	162	43	25	25	NUM
admet-1476	162	44	]	]	PUNCT
admet-1476	162	45	.	.	PUNCT
admet-1476	163	1	therefore	therefore	ADV
admet-1476	163	2	,	,	PUNCT
admet-1476	163	3	it	it	PRON
admet-1476	163	4	is	be	AUX
admet-1476	163	5	evident	evident	ADJ
admet-1476	163	6	that	that	SCONJ
admet-1476	163	7	the	the	DET
admet-1476	163	8	ionization	ionization	NOUN
admet-1476	163	9	is	be	AUX
admet-1476	163	10	playing	play	VERB
admet-1476	163	11	a	a	DET
admet-1476	163	12	major	major	ADJ
admet-1476	163	13	role	role	NOUN
admet-1476	163	14	in	in	ADP
admet-1476	163	15	the	the	DET
admet-1476	163	16	solubilization	solubilization	NOUN
admet-1476	163	17	of	of	ADP
admet-1476	163	18	furosemide	furosemide	NOUN
admet-1476	163	19	than	than	ADP
admet-1476	163	20	the	the	DET
admet-1476	163	21	bile	bile	NOUN
admet-1476	163	22	acid	acid	NOUN
admet-1476	163	23	and	and	CCONJ
admet-1476	163	24	salts	salt	NOUN
admet-1476	163	25	.	.	PUNCT
admet-1476	164	1	as	as	SCONJ
admet-1476	164	2	the	the	DET
admet-1476	164	3	experimental	experimental	ADJ
admet-1476	164	4	setup	setup	NOUN
admet-1476	164	5	could	could	AUX
admet-1476	164	6	not	not	PART
admet-1476	164	7	replicate	replicate	VERB
admet-1476	164	8	the	the	DET
admet-1476	164	9	in	in	ADP
admet-1476	164	10	vivo	vivo	NOUN
admet-1476	164	11	microclimate	microclimate	NOUN
admet-1476	164	12	ph	ph	NOUN
admet-1476	164	13	as	as	SCONJ
admet-1476	164	14	mentioned	mention	VERB
admet-1476	164	15	above	above	ADV
admet-1476	164	16	,	,	PUNCT
admet-1476	164	17	as	as	ADP
admet-1476	164	18	per	per	ADP
admet-1476	164	19	the	the	DET
admet-1476	164	20	phpartition	phpartition	NOUN
admet-1476	164	21	hypothesis	hypothesis	NOUN
admet-1476	164	22	the	the	DET
admet-1476	164	23	flux	flux	NOUN
admet-1476	164	24	data	datum	NOUN
admet-1476	164	25	obtained	obtain	VERB
admet-1476	164	26	during	during	ADP
admet-1476	164	27	µflux	µflux	NOUN
admet-1476	164	28	experiments	experiment	NOUN
admet-1476	164	29	showed	show	VERB
admet-1476	164	30	higher	high	ADJ
admet-1476	164	31	flux	flux	NOUN
admet-1476	164	32	in	in	ADP
admet-1476	164	33	fessif	fessif	PROPN
admet-1476	164	34	medium	medium	NOUN
admet-1476	164	35	(	(	PUNCT
admet-1476	164	36	figure	figure	NOUN
admet-1476	164	37	2	2	NUM
admet-1476	164	38	)	)	PUNCT
admet-1476	164	39	despite	despite	SCONJ
admet-1476	164	40	of	of	ADP
admet-1476	164	41	the	the	DET
admet-1476	164	42	higher	high	ADJ
admet-1476	164	43	solubility	solubility	NOUN
admet-1476	164	44	of	of	ADP
admet-1476	164	45	the	the	DET
admet-1476	164	46	drug	drug	NOUN
admet-1476	164	47	in	in	ADP
admet-1476	164	48	fassif	fassif	NOUN
admet-1476	164	49	,	,	PUNCT
admet-1476	164	50	and	and	CCONJ
admet-1476	164	51	identical	identical	ADJ
admet-1476	164	52	dissolution	dissolution	NOUN
admet-1476	164	53	in	in	ADP
admet-1476	164	54	both	both	DET
admet-1476	164	55	media	medium	NOUN
admet-1476	164	56	at	at	ADP
admet-1476	164	57	the	the	DET
admet-1476	164	58	level	level	NOUN
admet-1476	164	59	of	of	ADP
admet-1476	164	60	drug	drug	NOUN
admet-1476	164	61	dose	dose	NOUN
admet-1476	164	62	tested	test	VERB
admet-1476	164	63	(	(	PUNCT
admet-1476	164	64	figure	figure	NOUN
admet-1476	164	65	3	3	NUM
admet-1476	164	66	)	)	PUNCT
admet-1476	164	67	.	.	PUNCT
admet-1476	165	1	also	also	ADV
admet-1476	165	2	,	,	PUNCT
admet-1476	165	3	the	the	DET
admet-1476	165	4	sink	sink	NOUN
admet-1476	165	5	buffer	buffer	NOUN
admet-1476	165	6	ph	ph	NOUN
admet-1476	165	7	on	on	ADP
admet-1476	165	8	receiver	receiver	ADJ
admet-1476	165	9	side	side	NOUN
admet-1476	165	10	is	be	AUX
admet-1476	165	11	7.4	7.4	NUM
admet-1476	165	12	,	,	PUNCT
admet-1476	165	13	and	and	CCONJ
admet-1476	165	14	as	as	ADV
admet-1476	165	15	soon	soon	ADV
admet-1476	165	16	as	as	ADP
admet-1476	165	17	unionized	unionized	ADJ
admet-1476	165	18	furosemide	furosemide	NOUN
admet-1476	165	19	reaches	reach	VERB
admet-1476	165	20	the	the	DET
admet-1476	165	21	receiver	receiver	ADJ
admet-1476	165	22	compartment	compartment	NOUN
admet-1476	165	23	,	,	PUNCT
admet-1476	165	24	the	the	DET
admet-1476	165	25	molecule	molecule	NOUN
admet-1476	165	26	ionizes	ionize	NOUN
admet-1476	165	27	,	,	PUNCT
admet-1476	165	28	and	and	CCONJ
admet-1476	165	29	believed	believe	VERB
admet-1476	165	30	to	to	PART
admet-1476	165	31	create	create	VERB
admet-1476	165	32	an	an	DET
admet-1476	165	33	“	"	PUNCT
admet-1476	165	34	ion	ion	NOUN
admet-1476	165	35	-	-	PUNCT
admet-1476	165	36	trap	trap	NOUN
admet-1476	165	37	”	"	PUNCT
admet-1476	165	38	sink	sink	NOUN
admet-1476	165	39	[	[	X
admet-1476	165	40	34	34	NUM
admet-1476	165	41	]	]	PUNCT
admet-1476	165	42	.	.	PUNCT
admet-1476	166	1	therefore	therefore	ADV
admet-1476	166	2	,	,	PUNCT
admet-1476	166	3	despite	despite	SCONJ
admet-1476	166	4	of	of	ADP
admet-1476	166	5	the	the	DET
admet-1476	166	6	high	high	ADJ
admet-1476	166	7	solubility	solubility	NOUN
admet-1476	166	8	of	of	ADP
admet-1476	166	9	furosemide	furosemide	NOUN
admet-1476	166	10	in	in	ADP
admet-1476	166	11	fassif	fassif	NOUN
admet-1476	166	12	,	,	PUNCT
admet-1476	166	13	we	we	PRON
admet-1476	166	14	observed	observe	VERB
admet-1476	166	15	high	high	ADJ
admet-1476	166	16	diffusion	diffusion	NOUN
admet-1476	166	17	flux	flux	NOUN
admet-1476	166	18	in	in	ADP
admet-1476	166	19	fessif	fessif	NOUN
admet-1476	166	20	medium	medium	NOUN
admet-1476	166	21	during	during	ADP
admet-1476	166	22	in	in	ADP
admet-1476	166	23	vitro	vitro	X
admet-1476	166	24	experiment	experiment	NOUN
admet-1476	166	25	.	.	PUNCT
admet-1476	167	1	therefore	therefore	ADV
admet-1476	167	2	,	,	PUNCT
admet-1476	167	3	it	it	PRON
admet-1476	167	4	is	be	AUX
admet-1476	167	5	important	important	ADJ
admet-1476	167	6	to	to	PART
admet-1476	167	7	keep	keep	VERB
admet-1476	167	8	in	in	ADP
admet-1476	167	9	mind	mind	NOUN
admet-1476	167	10	the	the	DET
admet-1476	167	11	impact	impact	NOUN
admet-1476	167	12	of	of	ADP
admet-1476	167	13	the	the	DET
admet-1476	167	14	extent	extent	NOUN
admet-1476	167	15	of	of	ADP
admet-1476	167	16	ionization	ionization	NOUN
admet-1476	167	17	of	of	ADP
admet-1476	167	18	the	the	DET
admet-1476	167	19	drug	drug	NOUN
admet-1476	167	20	,	,	PUNCT
admet-1476	167	21	as	as	SCONJ
admet-1476	167	22	the	the	DET
admet-1476	167	23	ph	ph	ADJ
admet-1476	167	24	difference	difference	NOUN
admet-1476	167	25	between	between	ADP
admet-1476	167	26	fassif	fassif	NOUN
admet-1476	167	27	and	and	CCONJ
admet-1476	167	28	fessif	fessif	NOUN
admet-1476	167	29	may	may	AUX
admet-1476	167	30	lead	lead	VERB
admet-1476	167	31	to	to	ADP
admet-1476	167	32	misprediction	misprediction	NOUN
admet-1476	167	33	of	of	ADP
admet-1476	167	34	the	the	DET
admet-1476	167	35	fe	fe	PROPN
admet-1476	167	36	.	.	PROPN
admet-1476	167	37	isoniazid	isoniazid	PROPN
admet-1476	167	38	(	(	PUNCT
admet-1476	167	39	inh	inh	PROPN
admet-1476	167	40	)	)	PUNCT
admet-1476	167	41	is	be	AUX
admet-1476	167	42	an	an	DET
admet-1476	167	43	anti	anti	ADJ
admet-1476	167	44	-	-	ADJ
admet-1476	167	45	tubercular	tubercular	ADJ
admet-1476	167	46	bcs	bc	NOUN
admet-1476	167	47	-	-	PUNCT
admet-1476	167	48	i	i	PRON
admet-1476	167	49	hydrophilic	hydrophilic	ADJ
admet-1476	167	50	drug	drug	NOUN
admet-1476	167	51	with	with	ADP
admet-1476	167	52	very	very	ADV
admet-1476	167	53	high	high	ADJ
admet-1476	167	54	solubility	solubility	NOUN
admet-1476	167	55	(	(	PUNCT
admet-1476	167	56	>	>	NOUN
admet-1476	167	57	60	60	NUM
admet-1476	167	58	mg	mg	NUM
admet-1476	167	59	/	/	SYM
admet-1476	167	60	ml	ml	NOUN
admet-1476	167	61	)	)	PUNCT
admet-1476	167	62	in	in	ADP
admet-1476	167	63	both	both	DET
admet-1476	167	64	fassif	fassif	NOUN
admet-1476	167	65	and	and	CCONJ
admet-1476	167	66	fessif	fessif	VERB
admet-1476	167	67	media	medium	NOUN
admet-1476	167	68	.	.	PUNCT
admet-1476	168	1	isoniazid	isoniazid	PROPN
admet-1476	168	2	absorption	absorption	NOUN
admet-1476	168	3	is	be	AUX
admet-1476	168	4	reported	report	VERB
admet-1476	168	5	to	to	PART
admet-1476	168	6	be	be	AUX
admet-1476	168	7	reduced	reduce	VERB
admet-1476	168	8	following	follow	VERB
admet-1476	168	9	food	food	NOUN
admet-1476	168	10	intake	intake	NOUN
admet-1476	168	11	.	.	PUNCT
admet-1476	169	1	inh	inh	PROPN
admet-1476	169	2	is	be	AUX
admet-1476	169	3	reported	report	VERB
admet-1476	169	4	to	to	PART
admet-1476	169	5	be	be	AUX
admet-1476	169	6	converted	convert	VERB
admet-1476	169	7	to	to	ADP
admet-1476	169	8	a	a	DET
admet-1476	169	9	hydrazone	hydrazone	NOUN
admet-1476	169	10	species	specie	NOUN
admet-1476	169	11	in	in	ADP
admet-1476	169	12	fed	fed	PROPN
admet-1476	169	13	state	state	NOUN
admet-1476	169	14	,	,	PUNCT
admet-1476	169	15	making	make	VERB
admet-1476	169	16	it	it	PRON
admet-1476	169	17	less	less	ADV
admet-1476	169	18	available	available	ADJ
admet-1476	169	19	for	for	ADP
admet-1476	169	20	absorption	absorption	NOUN
admet-1476	169	21	.	.	PUNCT
admet-1476	170	1	though	though	SCONJ
admet-1476	170	2	all	all	DET
admet-1476	170	3	types	type	NOUN
admet-1476	170	4	of	of	ADP
admet-1476	170	5	meals	meal	NOUN
admet-1476	170	6	are	be	AUX
admet-1476	170	7	reported	report	VERB
admet-1476	170	8	to	to	PART
admet-1476	170	9	reduce	reduce	VERB
admet-1476	170	10	the	the	DET
admet-1476	170	11	isoniazid	isoniazid	NOUN
admet-1476	170	12	absorption	absorption	NOUN
admet-1476	170	13	,	,	PUNCT
admet-1476	170	14	the	the	DET
admet-1476	170	15	ingestion	ingestion	NOUN
admet-1476	170	16	of	of	ADP
admet-1476	170	17	a	a	DET
admet-1476	170	18	high	high	ADJ
admet-1476	170	19	carbohydrate	carbohydrate	NOUN
admet-1476	170	20	meal	meal	NOUN
admet-1476	170	21	reduced	reduce	VERB
admet-1476	170	22	the	the	DET
admet-1476	170	23	absorption	absorption	NOUN
admet-1476	170	24	to	to	ADP
admet-1476	170	25	maximum	maximum	ADJ
admet-1476	170	26	extent	extent	NOUN
admet-1476	170	27	[	[	X
admet-1476	170	28	35,36	35,36	NUM
admet-1476	170	29	]	]	PUNCT
admet-1476	170	30	.	.	PUNCT
admet-1476	171	1	the	the	DET
admet-1476	171	2	formation	formation	NOUN
admet-1476	171	3	of	of	ADP
admet-1476	171	4	the	the	DET
admet-1476	171	5	hydrazone	hydrazone	NOUN
admet-1476	171	6	species	specie	NOUN
admet-1476	171	7	in	in	ADP
admet-1476	171	8	fed	fed	PROPN
admet-1476	171	9	state	state	NOUN
admet-1476	171	10	and	and	CCONJ
admet-1476	171	11	hence	hence	ADV
admet-1476	171	12	reduced	reduce	VERB
admet-1476	171	13	absorption	absorption	NOUN
admet-1476	171	14	appears	appear	VERB
admet-1476	171	15	to	to	PART
admet-1476	171	16	be	be	AUX
admet-1476	171	17	the	the	DET
admet-1476	171	18	reason	reason	NOUN
admet-1476	171	19	for	for	ADP
admet-1476	171	20	the	the	DET
admet-1476	171	21	negative	negative	ADJ
admet-1476	171	22	food	food	NOUN
admet-1476	171	23	effect	effect	NOUN
admet-1476	171	24	observed	observe	VERB
admet-1476	171	25	in	in	ADP
admet-1476	171	26	clinical	clinical	ADJ
admet-1476	171	27	studies	study	NOUN
admet-1476	171	28	[	[	X
admet-1476	171	29	37	37	NUM
admet-1476	171	30	]	]	PUNCT
admet-1476	171	31	.	.	PUNCT
admet-1476	172	1	the	the	DET
admet-1476	172	2	observed	observe	VERB
admet-1476	172	3	clinical	clinical	ADJ
admet-1476	172	4	fed	fed	PROPN
admet-1476	172	5	/	/	SYM
admet-1476	172	6	fasting	fast	VERB
admet-1476	172	7	auc	auc	NOUN
admet-1476	172	8	and	and	CCONJ
admet-1476	172	9	cmax	cmax	NOUN
admet-1476	172	10	ratios	ratio	NOUN
admet-1476	172	11	were	be	AUX
admet-1476	172	12	0.88	0.88	NUM
admet-1476	172	13	and	and	CCONJ
admet-1476	172	14	0.49	0.49	NUM
admet-1476	172	15	respectively	respectively	ADV
admet-1476	172	16	.	.	PUNCT
admet-1476	173	1	inh	inh	PROPN
admet-1476	173	2	has	have	VERB
admet-1476	173	3	a	a	DET
admet-1476	173	4	basic	basic	ADJ
admet-1476	173	5	ionizable	ionizable	ADJ
admet-1476	173	6	group	group	NOUN
admet-1476	173	7	with	with	ADP
admet-1476	173	8	pka	pka	PROPN
admet-1476	173	9	3.8	3.8	NUM
admet-1476	173	10	,	,	PUNCT
admet-1476	173	11	thus	thus	ADV
admet-1476	173	12	in	in	ADP
admet-1476	173	13	fessif	fessif	NOUN
admet-1476	173	14	and	and	CCONJ
admet-1476	173	15	fassif	fassif	VERB
admet-1476	173	16	media	medium	NOUN
admet-1476	173	17	the	the	DET
admet-1476	173	18	drug	drug	NOUN
admet-1476	173	19	is	be	AUX
admet-1476	173	20	mainly	mainly	ADV
admet-1476	173	21	existing	exist	VERB
admet-1476	173	22	in	in	ADP
admet-1476	173	23	deprotonated	deprotonated	ADJ
admet-1476	173	24	,	,	PUNCT
admet-1476	173	25	admet	admet	PROPN
admet-1476	173	26	&	&	CCONJ
admet-1476	173	27	dmpk	dmpk	PROPN
admet-1476	173	28	10(4	10(4	NUM
admet-1476	173	29	)	)	PUNCT
admet-1476	173	30	(	(	PUNCT
admet-1476	173	31	2022	2022	NUM
admet-1476	173	32	)	)	PUNCT
admet-1476	173	33	299	299	NUM
admet-1476	173	34	-	-	SYM
admet-1476	173	35	314	314	NUM
admet-1476	173	36	material	material	NOUN
admet-1476	173	37	sparing	sparing	NOUN
admet-1476	173	38	µflux	µflux	NOUN
admet-1476	173	39	methodology	methodology	NOUN
admet-1476	173	40	doi	doi	NOUN
admet-1476	173	41	:	:	PUNCT
admet-1476	173	42	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	ADJ
admet-1476	173	43	307	307	NUM
admet-1476	173	44	neutral	neutral	ADJ
admet-1476	173	45	form	form	NOUN
admet-1476	173	46	.	.	PUNCT
admet-1476	174	1	in	in	ADP
admet-1476	174	2	agreement	agreement	NOUN
admet-1476	174	3	with	with	ADP
admet-1476	174	4	ph	ph	ADJ
admet-1476	174	5	-	-	PUNCT
admet-1476	174	6	partition	partition	NOUN
admet-1476	174	7	hypothesis	hypothesis	NOUN
admet-1476	174	8	,	,	PUNCT
admet-1476	174	9	the	the	DET
admet-1476	174	10	diffusion	diffusion	NOUN
admet-1476	174	11	flux	flux	NOUN
admet-1476	174	12	ratio	ratio	NOUN
admet-1476	174	13	between	between	ADP
admet-1476	174	14	fessif	fessif	NOUN
admet-1476	174	15	and	and	CCONJ
admet-1476	174	16	fassif	fassif	NOUN
admet-1476	174	17	did	do	AUX
admet-1476	174	18	not	not	PART
admet-1476	174	19	indicate	indicate	VERB
admet-1476	174	20	the	the	DET
admet-1476	174	21	extent	extent	NOUN
admet-1476	174	22	of	of	ADP
admet-1476	174	23	negative	negative	ADJ
admet-1476	174	24	food	food	NOUN
admet-1476	174	25	effect	effect	NOUN
admet-1476	174	26	that	that	PRON
admet-1476	174	27	was	be	AUX
admet-1476	174	28	observed	observe	VERB
admet-1476	174	29	in	in	ADP
admet-1476	174	30	the	the	DET
admet-1476	174	31	clinic	clinic	NOUN
admet-1476	174	32	(	(	PUNCT
admet-1476	174	33	figure	figure	NOUN
admet-1476	174	34	s5	s5	PROPN
admet-1476	174	35	;	;	PUNCT
admet-1476	174	36	supporting	support	VERB
admet-1476	174	37	information	information	NOUN
admet-1476	174	38	)	)	PUNCT
admet-1476	174	39	.	.	PUNCT
admet-1476	175	1	we	we	PRON
admet-1476	175	2	speculate	speculate	VERB
admet-1476	175	3	that	that	SCONJ
admet-1476	175	4	the	the	DET
admet-1476	175	5	absence	absence	NOUN
admet-1476	175	6	/	/	SYM
admet-1476	175	7	slow	slow	ADJ
admet-1476	175	8	hydrazone	hydrazone	NOUN
admet-1476	175	9	formation	formation	NOUN
admet-1476	175	10	in	in	ADP
admet-1476	175	11	the	the	DET
admet-1476	175	12	biorelevant	biorelevant	ADJ
admet-1476	175	13	medium	medium	ADJ
admet-1476	175	14	(	(	PUNCT
admet-1476	175	15	fessif	fessif	NOUN
admet-1476	175	16	)	)	PUNCT
admet-1476	175	17	,	,	PUNCT
admet-1476	175	18	might	might	AUX
admet-1476	175	19	be	be	AUX
admet-1476	175	20	the	the	DET
admet-1476	175	21	reason	reason	NOUN
admet-1476	175	22	for	for	ADP
admet-1476	175	23	not	not	PART
admet-1476	175	24	observing	observe	VERB
admet-1476	175	25	the	the	DET
admet-1476	175	26	negative	negative	ADJ
admet-1476	175	27	food	food	NOUN
admet-1476	175	28	effect	effect	NOUN
admet-1476	175	29	during	during	ADP
admet-1476	175	30	in	in	ADP
admet-1476	175	31	vitro	vitro	X
admet-1476	175	32	flux	flux	PROPN
admet-1476	175	33	measurement	measurement	PROPN
admet-1476	175	34	.	.	PUNCT
admet-1476	176	1	when	when	SCONJ
admet-1476	176	2	there	there	PRON
admet-1476	176	3	is	be	VERB
admet-1476	176	4	intestinal	intestinal	ADJ
admet-1476	176	5	metabolism	metabolism	NOUN
admet-1476	176	6	or	or	CCONJ
admet-1476	176	7	the	the	DET
admet-1476	176	8	influx	influx	NOUN
admet-1476	176	9	/	/	SYM
admet-1476	176	10	efflux	efflux	NOUN
admet-1476	176	11	transporters	transporter	NOUN
admet-1476	176	12	are	be	AUX
admet-1476	176	13	involved	involve	VERB
admet-1476	176	14	in	in	ADP
admet-1476	176	15	the	the	DET
admet-1476	176	16	drug	drug	NOUN
admet-1476	176	17	absorption	absorption	NOUN
admet-1476	176	18	,	,	PUNCT
admet-1476	176	19	the	the	DET
admet-1476	176	20	in	in	X
admet-1476	176	21	vitro	vitro	X
admet-1476	176	22	dissolution	dissolution	NOUN
admet-1476	176	23	/	/	SYM
admet-1476	176	24	flux	flux	NOUN
admet-1476	176	25	might	might	AUX
admet-1476	176	26	not	not	PART
admet-1476	176	27	be	be	AUX
admet-1476	176	28	able	able	ADJ
admet-1476	176	29	to	to	PART
admet-1476	176	30	predict	predict	VERB
admet-1476	176	31	the	the	DET
admet-1476	176	32	in	in	ADP
admet-1476	176	33	vivo	vivo	ADJ
admet-1476	176	34	food	food	NOUN
admet-1476	176	35	effect	effect	NOUN
admet-1476	176	36	since	since	SCONJ
admet-1476	176	37	the	the	DET
admet-1476	176	38	lipid	lipid	NOUN
admet-1476	176	39	-	-	PUNCT
admet-1476	176	40	coated	coat	VERB
admet-1476	176	41	artificial	artificial	ADJ
admet-1476	176	42	membrane	membrane	NOUN
admet-1476	176	43	is	be	AUX
admet-1476	176	44	not	not	PART
admet-1476	176	45	designed	design	VERB
admet-1476	176	46	to	to	PART
admet-1476	176	47	mimic	mimic	VERB
admet-1476	176	48	the	the	DET
admet-1476	176	49	paracellular	paracellular	ADJ
admet-1476	176	50	junction	junction	NOUN
admet-1476	176	51	or	or	CCONJ
admet-1476	176	52	active	active	ADJ
admet-1476	176	53	membrane	membrane	NOUN
admet-1476	176	54	transport	transport	NOUN
admet-1476	176	55	.	.	PUNCT
admet-1476	177	1	figure	figure	NOUN
admet-1476	177	2	2	2	NUM
admet-1476	177	3	.	.	NOUN
admet-1476	177	4	appearance	appearance	NOUN
admet-1476	177	5	kinetic	kinetic	NOUN
admet-1476	177	6	of	of	ADP
admet-1476	177	7	furosemide	furosemide	NOUN
admet-1476	177	8	in	in	ADP
admet-1476	177	9	the	the	DET
admet-1476	177	10	receiver	receiver	ADJ
admet-1476	177	11	chambers	chamber	NOUN
admet-1476	177	12	during	during	ADP
admet-1476	177	13	µflux	µflux	NOUN
admet-1476	177	14	experiment	experiment	NOUN
admet-1476	177	15	.	.	PUNCT
admet-1476	178	1	the	the	DET
admet-1476	178	2	corresponding	correspond	VERB
admet-1476	178	3	donor	donor	NOUN
admet-1476	178	4	chambers	chamber	NOUN
admet-1476	178	5	of	of	ADP
admet-1476	178	6	µflux	µflux	NOUN
admet-1476	178	7	pairs	pair	NOUN
admet-1476	178	8	were	be	AUX
admet-1476	178	9	filled	fill	VERB
admet-1476	178	10	with	with	ADP
admet-1476	178	11	fassif	fassif	NOUN
admet-1476	178	12	or	or	CCONJ
admet-1476	178	13	fessif	fessif	VERB
admet-1476	178	14	media	medium	NOUN
admet-1476	178	15	.	.	PUNCT
admet-1476	179	1	the	the	DET
admet-1476	179	2	flux	flux	NOUN
admet-1476	179	3	was	be	AUX
admet-1476	179	4	higher	high	ADJ
admet-1476	179	5	while	while	SCONJ
admet-1476	179	6	using	use	VERB
admet-1476	179	7	fessif	fessif	NOUN
admet-1476	179	8	medium	medium	PROPN
admet-1476	179	9	.	.	PUNCT
admet-1476	180	1	figure	figure	NOUN
admet-1476	180	2	3	3	NUM
admet-1476	180	3	.	.	PUNCT
admet-1476	181	1	dissolution	dissolution	PROPN
admet-1476	181	2	kinetic	kinetic	NOUN
admet-1476	181	3	of	of	ADP
admet-1476	181	4	furosemide	furosemide	NOUN
admet-1476	181	5	in	in	ADP
admet-1476	181	6	donor	donor	NOUN
admet-1476	181	7	compartments	compartment	NOUN
admet-1476	181	8	of	of	ADP
admet-1476	181	9	µflux	µflux	NOUN
admet-1476	181	10	pairs	pair	NOUN
admet-1476	181	11	.	.	PUNCT
admet-1476	182	1	0,0	0,0	NOUN
admet-1476	182	2	0,2	0,2	NUM
admet-1476	182	3	0,4	0,4	NUM
admet-1476	182	4	0,6	0,6	NUM
admet-1476	182	5	0,8	0,8	NUM
admet-1476	182	6	1,0	1,0	NUM
admet-1476	182	7	1,2	1,2	NUM
admet-1476	182	8	1,4	1,4	NUM
admet-1476	182	9	1,6	1,6	NUM
admet-1476	182	10	1,8	1,8	NUM
admet-1476	182	11	2,0	2,0	NUM
admet-1476	182	12	0	0	NUM
admet-1476	182	13	20	20	NUM
admet-1476	182	14	40	40	NUM
admet-1476	182	15	60	60	NUM
admet-1476	182	16	80	80	NUM
admet-1476	182	17	100	100	NUM
admet-1476	182	18	120	120	NUM
admet-1476	182	19	140	140	NUM
admet-1476	182	20	c	c	NOUN
admet-1476	182	21	o	o	NOUN
admet-1476	182	22	n	n	X
admet-1476	182	23	ce	ce	PROPN
admet-1476	182	24	n	n	CCONJ
admet-1476	182	25	tr	tr	VERB
admet-1476	182	26	a	a	DET
admet-1476	182	27	ti	ti	NOUN
admet-1476	182	28	o	o	NOUN
admet-1476	182	29	n	n	PROPN
admet-1476	182	30	(	(	PUNCT
admet-1476	182	31	µ	µ	X
admet-1476	182	32	g	g	NOUN
admet-1476	182	33	/m	/m	SYM
admet-1476	182	34	l	l	NOUN
admet-1476	182	35	)	)	PUNCT
admet-1476	182	36	time	time	NOUN
admet-1476	182	37	(	(	PUNCT
admet-1476	182	38	min	min	NOUN
admet-1476	182	39	)	)	PUNCT
admet-1476	182	40	fassif	fassif	VERB
admet-1476	182	41	fessif	fessif	NOUN
admet-1476	182	42	0	0	NUM
admet-1476	183	1	50	50	NUM
admet-1476	183	2	100	100	NUM
admet-1476	183	3	150	150	NUM
admet-1476	183	4	200	200	NUM
admet-1476	183	5	250	250	NUM
admet-1476	183	6	300	300	NUM
admet-1476	183	7	350	350	NUM
admet-1476	183	8	400	400	NUM
admet-1476	183	9	450	450	NUM
admet-1476	183	10	0	0	NUM
admet-1476	183	11	20	20	NUM
admet-1476	183	12	40	40	NUM
admet-1476	183	13	60	60	NUM
admet-1476	183	14	80	80	NUM
admet-1476	183	15	100	100	NUM
admet-1476	183	16	120	120	NUM
admet-1476	183	17	140	140	NUM
admet-1476	183	18	c	c	NOUN
admet-1476	183	19	o	o	NOUN
admet-1476	183	20	n	n	X
admet-1476	183	21	ce	ce	PROPN
admet-1476	183	22	n	n	CCONJ
admet-1476	183	23	tr	tr	VERB
admet-1476	183	24	a	a	DET
admet-1476	183	25	ti	ti	NOUN
admet-1476	183	26	o	o	NOUN
admet-1476	183	27	n	n	PROPN
admet-1476	183	28	(	(	PUNCT
admet-1476	183	29	µ	µ	X
admet-1476	183	30	g	g	NOUN
admet-1476	183	31	/m	/m	SYM
admet-1476	183	32	l	l	NOUN
admet-1476	183	33	)	)	PUNCT
admet-1476	183	34	time	time	NOUN
admet-1476	183	35	(	(	PUNCT
admet-1476	183	36	min	min	NOUN
admet-1476	183	37	)	)	PUNCT
admet-1476	183	38	fassif	fassif	VERB
admet-1476	183	39	fessif	fessif	VERB
admet-1476	183	40	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	PRON
admet-1476	183	41	c.	c.	PROPN
admet-1476	183	42	jankovsky	jankovsky	PROPN
admet-1476	183	43	et	et	PROPN
admet-1476	183	44	al	al	PROPN
admet-1476	183	45	.	.	PROPN
admet-1476	183	46	admet	admet	PROPN
admet-1476	183	47	&	&	CCONJ
admet-1476	183	48	dmpk	dmpk	PROPN
admet-1476	183	49	10(4	10(4	NUM
admet-1476	183	50	)	)	PUNCT
admet-1476	183	51	(	(	PUNCT
admet-1476	183	52	2022	2022	NUM
admet-1476	183	53	)	)	PUNCT
admet-1476	183	54	299	299	NUM
admet-1476	183	55	-	-	SYM
admet-1476	183	56	314	314	NUM
admet-1476	183	57	308	308	NUM
admet-1476	183	58	nefazodone	nefazodone	NOUN
admet-1476	183	59	hcl	hcl	PROPN
admet-1476	183	60	(	(	PUNCT
admet-1476	183	61	nzd	nzd	PROPN
admet-1476	183	62	)	)	PUNCT
admet-1476	183	63	,	,	PUNCT
admet-1476	183	64	an	an	DET
admet-1476	183	65	antidepressant	antidepressant	NOUN
admet-1476	183	66	,	,	PUNCT
admet-1476	183	67	is	be	AUX
admet-1476	183	68	reported	report	VERB
admet-1476	183	69	to	to	PART
admet-1476	183	70	exhibit	exhibit	VERB
admet-1476	183	71	negative	negative	ADJ
admet-1476	183	72	food	food	NOUN
admet-1476	183	73	effect	effect	NOUN
admet-1476	183	74	in	in	ADP
admet-1476	183	75	clinic	clinic	NOUN
admet-1476	184	1	[	[	X
admet-1476	184	2	38	38	NUM
admet-1476	184	3	]	]	PUNCT
admet-1476	184	4	.	.	PUNCT
admet-1476	185	1	it	it	PRON
admet-1476	185	2	is	be	AUX
admet-1476	185	3	a	a	DET
admet-1476	185	4	lipophilic	lipophilic	ADJ
admet-1476	185	5	diprotic	diprotic	ADJ
admet-1476	185	6	base	base	NOUN
admet-1476	185	7	which	which	PRON
admet-1476	185	8	has	have	VERB
admet-1476	185	9	two	two	NUM
admet-1476	185	10	ionizable	ionizable	ADJ
admet-1476	185	11	groups	group	NOUN
admet-1476	185	12	at	at	ADP
admet-1476	185	13	pka	pka	PROPN
admet-1476	185	14	at	at	ADP
admet-1476	185	15	2.1	2.1	NUM
admet-1476	185	16	and	and	CCONJ
admet-1476	185	17	6.7	6.7	NUM
admet-1476	185	18	.	.	PUNCT
admet-1476	186	1	since	since	SCONJ
admet-1476	186	2	at	at	ADP
admet-1476	186	3	ph	ph	PROPN
admet-1476	186	4	6.5	6.5	NUM
admet-1476	186	5	the	the	DET
admet-1476	186	6	drug	drug	NOUN
admet-1476	186	7	is	be	AUX
admet-1476	186	8	more	more	ADV
admet-1476	186	9	de	de	ADJ
admet-1476	186	10	-	-	VERB
admet-1476	186	11	protonated	protonated	ADJ
admet-1476	186	12	than	than	ADP
admet-1476	186	13	at	at	ADP
admet-1476	186	14	ph	ph	ADJ
admet-1476	186	15	5.0	5.0	NUM
admet-1476	186	16	,	,	PUNCT
admet-1476	186	17	it	it	PRON
admet-1476	186	18	is	be	AUX
admet-1476	186	19	expected	expect	VERB
admet-1476	186	20	to	to	PART
admet-1476	186	21	observe	observe	VERB
admet-1476	186	22	higher	high	ADJ
admet-1476	186	23	membrane	membrane	NOUN
admet-1476	186	24	permeability	permeability	NOUN
admet-1476	186	25	at	at	ADP
admet-1476	186	26	ph	ph	PROPN
admet-1476	186	27	6.5	6.5	NUM
admet-1476	186	28	comparing	compare	VERB
admet-1476	186	29	to	to	ADP
admet-1476	186	30	ph	ph	PROPN
admet-1476	186	31	5.0	5.0	NUM
admet-1476	186	32	in	in	ADP
admet-1476	186	33	aqueous	aqueous	ADJ
admet-1476	186	34	buffers	buffer	NOUN
admet-1476	186	35	.	.	PUNCT
admet-1476	187	1	nefazodone	nefazodone	NOUN
admet-1476	187	2	hcl	hcl	PROPN
admet-1476	187	3	is	be	AUX
admet-1476	187	4	a	a	DET
admet-1476	187	5	bcs	bcs	NOUN
admet-1476	187	6	-	-	PUNCT
admet-1476	187	7	ii	ii	NOUN
admet-1476	187	8	drug	drug	NOUN
admet-1476	187	9	,	,	PUNCT
admet-1476	187	10	showing	show	VERB
admet-1476	187	11	a	a	DET
admet-1476	187	12	low	low	ADJ
admet-1476	187	13	solubility	solubility	NOUN
admet-1476	187	14	and	and	CCONJ
admet-1476	187	15	high	high	ADJ
admet-1476	187	16	permeability	permeability	NOUN
admet-1476	187	17	.	.	PUNCT
admet-1476	188	1	the	the	DET
admet-1476	188	2	solubility	solubility	NOUN
admet-1476	188	3	ratio	ratio	NOUN
admet-1476	188	4	between	between	ADP
admet-1476	188	5	fessif	fessif	NOUN
admet-1476	188	6	and	and	CCONJ
admet-1476	188	7	fassif	fassif	NOUN
admet-1476	188	8	was	be	AUX
admet-1476	188	9	determined	determined	ADJ
admet-1476	188	10	to	to	PART
admet-1476	188	11	be	be	AUX
admet-1476	188	12	1.52	1.52	NUM
admet-1476	188	13	indicating	indicate	VERB
admet-1476	188	14	a	a	DET
admet-1476	188	15	positive	positive	ADJ
admet-1476	188	16	food	food	NOUN
admet-1476	188	17	effect	effect	NOUN
admet-1476	188	18	(	(	PUNCT
admet-1476	188	19	table	table	NOUN
admet-1476	188	20	3	3	NUM
admet-1476	188	21	)	)	PUNCT
admet-1476	188	22	unlike	unlike	ADP
admet-1476	188	23	the	the	DET
admet-1476	188	24	negative	negative	ADJ
admet-1476	188	25	food	food	NOUN
admet-1476	188	26	effect	effect	NOUN
admet-1476	188	27	reported	report	VERB
admet-1476	188	28	in	in	ADP
admet-1476	188	29	the	the	DET
admet-1476	188	30	clinic	clinic	NOUN
admet-1476	188	31	.	.	PUNCT
admet-1476	189	1	the	the	DET
admet-1476	189	2	bile	bile	NOUN
admet-1476	189	3	salts	salt	NOUN
admet-1476	189	4	,	,	PUNCT
admet-1476	189	5	phospholipids	phospholipid	NOUN
admet-1476	189	6	,	,	PUNCT
admet-1476	189	7	and	and	CCONJ
admet-1476	189	8	cholesterol	cholesterol	NOUN
admet-1476	189	9	concentration	concentration	NOUN
admet-1476	189	10	are	be	AUX
admet-1476	189	11	higher	high	ADJ
admet-1476	189	12	in	in	ADP
admet-1476	189	13	fed	fed	PROPN
admet-1476	189	14	state	state	NOUN
admet-1476	189	15	in	in	ADP
admet-1476	189	16	vivo	vivo	NOUN
admet-1476	189	17	and	and	CCONJ
admet-1476	189	18	in	in	ADP
admet-1476	189	19	simulated	simulated	ADJ
admet-1476	189	20	intestine	intestine	NOUN
admet-1476	189	21	fluid	fluid	NOUN
admet-1476	189	22	.	.	PUNCT
admet-1476	190	1	bile	bile	NOUN
admet-1476	190	2	salts	salt	NOUN
admet-1476	190	3	are	be	AUX
admet-1476	190	4	surface	surface	NOUN
admet-1476	190	5	active	active	ADJ
admet-1476	190	6	compounds	compound	NOUN
admet-1476	190	7	and	and	CCONJ
admet-1476	190	8	when	when	SCONJ
admet-1476	190	9	their	their	PRON
admet-1476	190	10	concentration	concentration	NOUN
admet-1476	190	11	is	be	AUX
admet-1476	190	12	above	above	ADP
admet-1476	190	13	the	the	DET
admet-1476	190	14	critical	critical	ADJ
admet-1476	190	15	micelle	micelle	NOUN
admet-1476	190	16	concentration	concentration	NOUN
admet-1476	190	17	,	,	PUNCT
admet-1476	190	18	bile	bile	NOUN
admet-1476	190	19	salts	salt	NOUN
admet-1476	190	20	aggregate	aggregate	VERB
admet-1476	190	21	and	and	CCONJ
admet-1476	190	22	form	form	NOUN
admet-1476	190	23	micelles	micelle	NOUN
admet-1476	190	24	.	.	PUNCT
admet-1476	191	1	these	these	DET
admet-1476	191	2	micelles	micelle	NOUN
admet-1476	191	3	help	help	VERB
admet-1476	191	4	in	in	ADP
admet-1476	191	5	solubilization	solubilization	NOUN
admet-1476	191	6	of	of	ADP
admet-1476	191	7	drugs	drug	NOUN
admet-1476	191	8	with	with	ADP
admet-1476	191	9	low	low	ADJ
admet-1476	191	10	aqueous	aqueous	ADJ
admet-1476	191	11	solubility	solubility	NOUN
admet-1476	191	12	[	[	X
admet-1476	191	13	39	39	NUM
admet-1476	191	14	]	]	PUNCT
admet-1476	191	15	.	.	PUNCT
admet-1476	192	1	but	but	CCONJ
admet-1476	192	2	solubilization	solubilization	NOUN
admet-1476	192	3	of	of	ADP
admet-1476	192	4	drugs	drug	NOUN
admet-1476	192	5	may	may	AUX
admet-1476	192	6	not	not	PART
admet-1476	192	7	always	always	ADV
admet-1476	192	8	increase	increase	VERB
admet-1476	192	9	their	their	PRON
admet-1476	192	10	absorption	absorption	NOUN
admet-1476	192	11	.	.	PUNCT
admet-1476	193	1	the	the	DET
admet-1476	193	2	bile	bile	NOUN
admet-1476	193	3	micelles	micelle	NOUN
admet-1476	193	4	may	may	AUX
admet-1476	193	5	“	"	PUNCT
admet-1476	193	6	entrap	entrap	VERB
admet-1476	193	7	”	"	PUNCT
admet-1476	193	8	a	a	DET
admet-1476	193	9	drug	drug	NOUN
admet-1476	193	10	molecule	molecule	NOUN
admet-1476	193	11	thereby	thereby	ADV
admet-1476	193	12	reducing	reduce	VERB
admet-1476	193	13	the	the	DET
admet-1476	193	14	concentration	concentration	NOUN
admet-1476	193	15	of	of	ADP
admet-1476	193	16	free	free	ADJ
admet-1476	193	17	drug	drug	NOUN
admet-1476	193	18	available	available	ADJ
admet-1476	193	19	at	at	ADP
admet-1476	193	20	the	the	DET
admet-1476	193	21	epithelial	epithelial	ADJ
admet-1476	193	22	membrane	membrane	NOUN
admet-1476	193	23	surface	surface	NOUN
admet-1476	193	24	.	.	PUNCT
admet-1476	194	1	micelle	micelle	NOUN
admet-1476	194	2	formation	formation	NOUN
admet-1476	194	3	may	may	AUX
admet-1476	194	4	also	also	ADV
admet-1476	194	5	reduce	reduce	VERB
admet-1476	194	6	the	the	DET
admet-1476	194	7	diffusion	diffusion	NOUN
admet-1476	194	8	coefficient	coefficient	NOUN
admet-1476	194	9	of	of	ADP
admet-1476	194	10	the	the	DET
admet-1476	194	11	drug	drug	NOUN
admet-1476	194	12	in	in	ADP
admet-1476	194	13	the	the	DET
admet-1476	194	14	unstirred	unstirred	ADJ
admet-1476	194	15	water	water	NOUN
admet-1476	194	16	layer	layer	NOUN
admet-1476	194	17	.	.	PUNCT
admet-1476	195	1	the	the	DET
admet-1476	195	2	flux	flux	NOUN
admet-1476	195	3	experiments	experiment	NOUN
admet-1476	195	4	were	be	AUX
admet-1476	195	5	conducted	conduct	VERB
admet-1476	195	6	for	for	ADP
admet-1476	195	7	nzd	nzd	NOUN
admet-1476	195	8	in	in	ADP
admet-1476	195	9	two	two	NUM
admet-1476	195	10	ways	way	NOUN
admet-1476	195	11	,	,	PUNCT
admet-1476	195	12	introducing	introduce	VERB
admet-1476	195	13	sample	sample	NOUN
admet-1476	195	14	in	in	ADP
admet-1476	195	15	the	the	DET
admet-1476	195	16	donor	donor	NOUN
admet-1476	195	17	compartments	compartment	NOUN
admet-1476	195	18	as	as	ADP
admet-1476	195	19	a	a	DET
admet-1476	195	20	dry	dry	ADJ
admet-1476	195	21	powder	powder	NOUN
admet-1476	195	22	of	of	ADP
admet-1476	195	23	unformulated	unformulated	ADJ
admet-1476	195	24	material	material	NOUN
admet-1476	195	25	and	and	CCONJ
admet-1476	195	26	as	as	ADP
admet-1476	195	27	a	a	DET
admet-1476	195	28	“	"	PUNCT
admet-1476	195	29	slurry	slurry	NOUN
admet-1476	195	30	”	"	PUNCT
admet-1476	195	31	of	of	ADP
admet-1476	195	32	ds	ds	NOUN
admet-1476	195	33	in	in	ADP
admet-1476	195	34	the	the	DET
admet-1476	195	35	corresponding	corresponding	ADJ
admet-1476	195	36	biorelevant	biorelevant	NOUN
admet-1476	195	37	media	medium	NOUN
admet-1476	195	38	at	at	ADP
admet-1476	195	39	concentration	concentration	NOUN
admet-1476	195	40	0.4	0.4	NUM
admet-1476	195	41	mg	mg	PROPN
admet-1476	195	42	/	/	SYM
admet-1476	195	43	ml	ml	NOUN
admet-1476	195	44	.	.	PUNCT
admet-1476	196	1	the	the	DET
admet-1476	196	2	sample	sample	NOUN
admet-1476	196	3	,	,	PUNCT
admet-1476	196	4	assayed	assayed	ADJ
admet-1476	196	5	as	as	ADP
admet-1476	196	6	a	a	DET
admet-1476	196	7	dry	dry	ADJ
admet-1476	196	8	powder	powder	NOUN
admet-1476	196	9	showed	show	VERB
admet-1476	196	10	poor	poor	ADJ
admet-1476	196	11	wettability	wettability	NOUN
admet-1476	196	12	in	in	ADP
admet-1476	196	13	fassif	fassif	NOUN
admet-1476	196	14	comparing	compare	VERB
admet-1476	196	15	to	to	ADP
admet-1476	196	16	fessif	fessif	NOUN
admet-1476	196	17	creating	create	VERB
admet-1476	196	18	“	"	PUNCT
admet-1476	196	19	grease	grease	NOUN
admet-1476	196	20	balls	ball	NOUN
admet-1476	196	21	”	"	PUNCT
admet-1476	196	22	,	,	PUNCT
admet-1476	196	23	that	that	PRON
admet-1476	196	24	significantly	significantly	ADV
admet-1476	196	25	reduced	reduce	VERB
admet-1476	196	26	the	the	DET
admet-1476	196	27	surface	surface	NOUN
admet-1476	196	28	area	area	NOUN
admet-1476	196	29	of	of	ADP
admet-1476	196	30	the	the	DET
admet-1476	196	31	drug	drug	NOUN
admet-1476	196	32	significantly	significantly	ADV
admet-1476	196	33	slowing	slow	VERB
admet-1476	196	34	down	down	ADP
admet-1476	196	35	the	the	DET
admet-1476	196	36	dissolution	dissolution	NOUN
admet-1476	196	37	process	process	NOUN
admet-1476	196	38	.	.	PUNCT
admet-1476	197	1	however	however	ADV
admet-1476	197	2	,	,	PUNCT
admet-1476	197	3	assayed	assayed	ADJ
admet-1476	197	4	in	in	ADP
admet-1476	197	5	form	form	NOUN
admet-1476	197	6	of	of	ADP
admet-1476	197	7	“	"	PUNCT
admet-1476	197	8	slurry	slurry	NOUN
admet-1476	197	9	”	"	PUNCT
admet-1476	197	10	,	,	PUNCT
admet-1476	197	11	the	the	DET
admet-1476	197	12	flux	flux	NOUN
admet-1476	197	13	ratio	ratio	NOUN
admet-1476	197	14	between	between	ADP
admet-1476	197	15	fessif	fessif	NOUN
admet-1476	197	16	and	and	CCONJ
admet-1476	197	17	fassif	fassif	NOUN
admet-1476	197	18	was	be	AUX
admet-1476	197	19	determined	determined	ADJ
admet-1476	197	20	to	to	PART
admet-1476	197	21	be	be	AUX
admet-1476	197	22	0.74	0.74	NUM
admet-1476	197	23	,	,	PUNCT
admet-1476	197	24	indicating	indicate	VERB
admet-1476	197	25	a	a	DET
admet-1476	197	26	negative	negative	ADJ
admet-1476	197	27	food	food	NOUN
admet-1476	197	28	effect	effect	NOUN
admet-1476	197	29	(	(	PUNCT
admet-1476	197	30	table	table	NOUN
admet-1476	197	31	3	3	NUM
admet-1476	197	32	;	;	PUNCT
admet-1476	197	33	figure	figure	NOUN
admet-1476	197	34	s6	s6	PROPN
admet-1476	197	35	;	;	PUNCT
admet-1476	197	36	supporting	support	VERB
admet-1476	197	37	information	information	NOUN
admet-1476	197	38	)	)	PUNCT
admet-1476	197	39	.	.	PUNCT
admet-1476	198	1	it	it	PRON
admet-1476	198	2	is	be	AUX
admet-1476	198	3	imperative	imperative	ADJ
admet-1476	198	4	to	to	PART
admet-1476	198	5	note	note	VERB
admet-1476	198	6	that	that	SCONJ
admet-1476	198	7	the	the	DET
admet-1476	198	8	wettability	wettability	NOUN
admet-1476	198	9	and	and	CCONJ
admet-1476	198	10	surface	surface	NOUN
admet-1476	198	11	area	area	NOUN
admet-1476	198	12	of	of	ADP
admet-1476	198	13	a	a	DET
admet-1476	198	14	drug	drug	NOUN
admet-1476	198	15	substance	substance	NOUN
admet-1476	198	16	may	may	AUX
admet-1476	198	17	influence	influence	VERB
admet-1476	198	18	the	the	DET
admet-1476	198	19	results	result	NOUN
admet-1476	198	20	in	in	ADP
admet-1476	198	21	flux	flux	NOUN
admet-1476	198	22	assays	assay	NOUN
admet-1476	198	23	conducted	conduct	VERB
admet-1476	198	24	for	for	ADP
admet-1476	198	25	unformulated	unformulated	ADJ
admet-1476	198	26	drug	drug	NOUN
admet-1476	198	27	substance	substance	NOUN
admet-1476	198	28	compared	compare	VERB
admet-1476	198	29	to	to	ADP
admet-1476	198	30	a	a	DET
admet-1476	198	31	drug	drug	NOUN
admet-1476	198	32	formulation	formulation	NOUN
admet-1476	198	33	.	.	PUNCT
admet-1476	199	1	the	the	DET
admet-1476	199	2	relationships	relationship	NOUN
admet-1476	199	3	between	between	ADP
admet-1476	199	4	the	the	DET
admet-1476	199	5	limiting	limit	VERB
admet-1476	199	6	steps	step	NOUN
admet-1476	199	7	of	of	ADP
admet-1476	199	8	oral	oral	ADJ
admet-1476	199	9	absorption	absorption	NOUN
admet-1476	199	10	(	(	PUNCT
admet-1476	199	11	permeability	permeability	NOUN
admet-1476	199	12	limited	limit	VERB
admet-1476	199	13	,	,	PUNCT
admet-1476	199	14	dissolution	dissolution	NOUN
admet-1476	199	15	rate	rate	NOUN
admet-1476	199	16	limited	limit	VERB
admet-1476	199	17	,	,	PUNCT
admet-1476	199	18	and	and	CCONJ
admet-1476	199	19	solubility	solubility	NOUN
admet-1476	199	20	limited	limit	VERB
admet-1476	199	21	)	)	PUNCT
admet-1476	199	22	,	,	PUNCT
admet-1476	199	23	and	and	CCONJ
admet-1476	199	24	the	the	DET
admet-1476	199	25	food	food	NOUN
admet-1476	199	26	effects	effect	NOUN
admet-1476	199	27	by	by	ADP
admet-1476	199	28	bile	bile	NOUN
admet-1476	199	29	micelles	micelle	NOUN
admet-1476	199	30	have	have	AUX
admet-1476	199	31	been	be	AUX
admet-1476	199	32	outlined	outline	VERB
admet-1476	199	33	and	and	CCONJ
admet-1476	199	34	discussed	discuss	VERB
admet-1476	199	35	[	[	X
admet-1476	199	36	40	40	NUM
admet-1476	199	37	]	]	PUNCT
admet-1476	199	38	.	.	PUNCT
admet-1476	200	1	fluoxetine	fluoxetine	PROPN
admet-1476	200	2	hcl	hcl	PROPN
admet-1476	200	3	(	(	PUNCT
admet-1476	200	4	fxt	fxt	PROPN
admet-1476	200	5	)	)	PUNCT
admet-1476	200	6	is	be	AUX
admet-1476	200	7	bcs	bc	NOUN
admet-1476	200	8	-	-	PUNCT
admet-1476	200	9	i	i	PRON
admet-1476	200	10	selective	selective	ADJ
admet-1476	200	11	serotonin	serotonin	NOUN
admet-1476	200	12	reuptake	reuptake	NOUN
admet-1476	200	13	inhibitor	inhibitor	NOUN
admet-1476	200	14	is	be	AUX
admet-1476	200	15	used	use	VERB
admet-1476	200	16	to	to	PART
admet-1476	200	17	treat	treat	VERB
admet-1476	200	18	depression	depression	NOUN
admet-1476	200	19	,	,	PUNCT
admet-1476	200	20	obsessive	obsessive	ADJ
admet-1476	200	21	compulsive	compulsive	ADJ
admet-1476	200	22	disorder	disorder	NOUN
admet-1476	200	23	as	as	ADV
admet-1476	200	24	well	well	ADV
admet-1476	200	25	as	as	ADP
admet-1476	200	26	some	some	DET
admet-1476	200	27	other	other	ADJ
admet-1476	200	28	forms	form	NOUN
admet-1476	200	29	of	of	ADP
admet-1476	200	30	eating	eat	VERB
admet-1476	200	31	disorders	disorder	NOUN
admet-1476	200	32	.	.	PUNCT
admet-1476	201	1	the	the	DET
admet-1476	201	2	clinical	clinical	ADJ
admet-1476	201	3	studies	study	NOUN
admet-1476	201	4	demonstrated	demonstrate	VERB
admet-1476	201	5	that	that	SCONJ
admet-1476	201	6	extend	extend	NOUN
admet-1476	201	7	of	of	ADP
admet-1476	201	8	absorption	absorption	NOUN
admet-1476	201	9	of	of	ADP
admet-1476	201	10	fxt	fxt	PROPN
admet-1476	201	11	is	be	AUX
admet-1476	201	12	not	not	PART
admet-1476	201	13	influenced	influence	VERB
admet-1476	201	14	by	by	ADP
admet-1476	201	15	presence	presence	NOUN
admet-1476	201	16	or	or	CCONJ
admet-1476	201	17	absence	absence	NOUN
admet-1476	201	18	of	of	ADP
admet-1476	201	19	food	food	NOUN
admet-1476	201	20	reporting	report	VERB
admet-1476	201	21	fed	fed	PROPN
admet-1476	201	22	/	/	SYM
admet-1476	201	23	fasting	fast	VERB
admet-1476	201	24	auc	auc	NOUN
admet-1476	201	25	and	and	CCONJ
admet-1476	201	26	cmax	cmax	VERB
admet-1476	201	27	ratios	ratio	NOUN
admet-1476	201	28	0.96	0.96	NUM
admet-1476	201	29	and	and	CCONJ
admet-1476	201	30	0.85	0.85	NUM
admet-1476	201	31	respectively	respectively	ADV
admet-1476	201	32	[	[	X
admet-1476	201	33	41	41	NUM
admet-1476	201	34	]	]	PUNCT
admet-1476	201	35	.	.	PUNCT
admet-1476	202	1	fxt	fxt	PROPN
admet-1476	202	2	is	be	AUX
admet-1476	202	3	a	a	DET
admet-1476	202	4	monoprotic	monoprotic	ADJ
admet-1476	202	5	highly	highly	ADV
admet-1476	202	6	lipophilic	lipophilic	ADJ
admet-1476	202	7	weak	weak	ADJ
admet-1476	202	8	base	base	NOUN
admet-1476	202	9	with	with	ADP
admet-1476	202	10	pka	pka	PROPN
admet-1476	202	11	9.62	9.62	NUM
admet-1476	202	12	.	.	PUNCT
admet-1476	203	1	in	in	ADP
admet-1476	203	2	physiological	physiological	ADJ
admet-1476	203	3	ph	ph	NOUN
admet-1476	203	4	range	range	NOUN
admet-1476	203	5	the	the	DET
admet-1476	203	6	compound	compound	NOUN
admet-1476	203	7	is	be	AUX
admet-1476	203	8	mostly	mostly	ADV
admet-1476	203	9	remains	remain	VERB
admet-1476	203	10	in	in	ADP
admet-1476	203	11	its	its	PRON
admet-1476	203	12	protonated	protonated	ADJ
admet-1476	203	13	state	state	NOUN
admet-1476	203	14	reaching	reach	VERB
admet-1476	203	15	fully	fully	ADV
admet-1476	203	16	deprotonated	deprotonated	ADJ
admet-1476	203	17	state	state	NOUN
admet-1476	203	18	above	above	ADP
admet-1476	203	19	ph	ph	PROPN
admet-1476	203	20	9.7	9.7	NUM
admet-1476	203	21	.	.	PUNCT
admet-1476	204	1	despite	despite	SCONJ
admet-1476	204	2	high	high	ADJ
admet-1476	204	3	lipophilicity	lipophilicity	NOUN
admet-1476	204	4	,	,	PUNCT
admet-1476	204	5	compound	compound	NOUN
admet-1476	204	6	reported	report	VERB
admet-1476	204	7	to	to	PART
admet-1476	204	8	be	be	AUX
admet-1476	204	9	soluble	soluble	ADJ
admet-1476	204	10	in	in	ADP
admet-1476	204	11	fassif	fassif	NOUN
admet-1476	204	12	(	(	PUNCT
admet-1476	204	13	1380	1380	NUM
admet-1476	204	14	µg	µg	NOUN
admet-1476	204	15	/	/	SYM
admet-1476	204	16	ml	ml	NOUN
admet-1476	204	17	)	)	PUNCT
admet-1476	204	18	and	and	CCONJ
admet-1476	204	19	fessif	fessif	INTJ
admet-1476	204	20	(	(	PUNCT
admet-1476	204	21	1620	1620	NUM
admet-1476	204	22	µg	µg	NOUN
admet-1476	204	23	/	/	SYM
admet-1476	204	24	ml	ml	NOUN
admet-1476	204	25	)	)	PUNCT
admet-1476	204	26	,	,	PUNCT
admet-1476	204	27	showing	show	VERB
admet-1476	204	28	no	no	DET
admet-1476	204	29	food	food	NOUN
admet-1476	204	30	effect	effect	NOUN
admet-1476	204	31	based	base	VERB
admet-1476	204	32	on	on	ADP
admet-1476	204	33	fed	fed	PROPN
admet-1476	204	34	/	/	SYM
admet-1476	204	35	fasted	fast	VERB
admet-1476	204	36	solubility	solubility	NOUN
admet-1476	204	37	ratio	ratio	NOUN
admet-1476	204	38	1.17	1.17	NUM
admet-1476	204	39	what	what	PRON
admet-1476	204	40	correlates	correlate	VERB
admet-1476	204	41	with	with	ADP
admet-1476	204	42	fed	fed	PROPN
admet-1476	204	43	/	/	SYM
admet-1476	204	44	fasted	fast	VERB
admet-1476	204	45	auc	auc	NOUN
admet-1476	204	46	ratios	ratio	NOUN
admet-1476	204	47	reported	report	VERB
admet-1476	204	48	in	in	ADP
admet-1476	204	49	clinic	clinic	NOUN
admet-1476	204	50	.	.	PUNCT
admet-1476	205	1	data	datum	NOUN
admet-1476	205	2	collected	collect	VERB
admet-1476	205	3	during	during	ADP
admet-1476	205	4	flux	flux	NOUN
admet-1476	205	5	experiments	experiment	NOUN
admet-1476	205	6	shows	show	VERB
admet-1476	205	7	that	that	SCONJ
admet-1476	205	8	in	in	ADP
admet-1476	205	9	the	the	DET
admet-1476	205	10	presence	presence	NOUN
admet-1476	205	11	of	of	ADP
admet-1476	205	12	the	the	DET
admet-1476	205	13	lipophilic	lipophilic	ADJ
admet-1476	205	14	barrier	barrier	NOUN
admet-1476	205	15	,	,	PUNCT
admet-1476	205	16	more	more	ADV
admet-1476	205	17	complex	complex	ADJ
admet-1476	205	18	processes	process	NOUN
admet-1476	205	19	may	may	AUX
admet-1476	205	20	occur	occur	VERB
admet-1476	205	21	in	in	ADP
admet-1476	205	22	donor	donor	NOUN
admet-1476	205	23	,	,	PUNCT
admet-1476	205	24	especially	especially	ADV
admet-1476	205	25	in	in	ADP
admet-1476	205	26	fassif	fassif	NOUN
admet-1476	205	27	medium	medium	NOUN
admet-1476	205	28	.	.	PUNCT
admet-1476	206	1	to	to	PART
admet-1476	206	2	better	well	ADV
admet-1476	206	3	understand	understand	VERB
admet-1476	206	4	an	an	DET
admet-1476	206	5	intricate	intricate	ADJ
admet-1476	206	6	solubility	solubility	NOUN
admet-1476	206	7	-	-	PUNCT
admet-1476	206	8	permeability	permeability	NOUN
admet-1476	206	9	interplay	interplay	NOUN
admet-1476	206	10	observed	observe	VERB
admet-1476	206	11	in	in	ADP
admet-1476	206	12	vitro	vitro	X
admet-1476	206	13	,	,	PUNCT
admet-1476	206	14	flux	flux	NOUN
admet-1476	206	15	experiments	experiment	NOUN
admet-1476	206	16	were	be	AUX
admet-1476	206	17	conducted	conduct	VERB
admet-1476	206	18	at	at	ADP
admet-1476	206	19	several	several	ADJ
admet-1476	206	20	doses	dose	NOUN
admet-1476	206	21	of	of	ADP
admet-1476	206	22	unformulated	unformulated	ADJ
admet-1476	206	23	drug	drug	NOUN
admet-1476	206	24	substance	substance	NOUN
admet-1476	206	25	(	(	PUNCT
admet-1476	206	26	equivalent	equivalent	ADJ
admet-1476	206	27	to	to	ADP
admet-1476	206	28	20	20	NUM
admet-1476	206	29	mg	mg	NOUN
admet-1476	206	30	,	,	PUNCT
admet-1476	206	31	40	40	NUM
admet-1476	206	32	mg	mg	NOUN
admet-1476	206	33	,	,	PUNCT
admet-1476	206	34	and	and	CCONJ
admet-1476	206	35	200	200	NUM
admet-1476	206	36	mg	mg	PROPN
admet-1476	206	37	dose	dose	PROPN
admet-1476	206	38	)	)	PUNCT
admet-1476	206	39	in	in	ADP
admet-1476	206	40	fassif	fassif	NOUN
admet-1476	206	41	,	,	PUNCT
admet-1476	206	42	fessif	fessif	NOUN
admet-1476	206	43	and	and	CCONJ
admet-1476	206	44	in	in	ADP
admet-1476	206	45	the	the	DET
admet-1476	206	46	corresponding	corresponding	ADJ
admet-1476	206	47	plain	plain	ADJ
admet-1476	206	48	buffers	buffer	NOUN
admet-1476	206	49	(	(	PUNCT
admet-1476	206	50	herein	herein	ADV
admet-1476	206	51	referred	refer	VERB
admet-1476	206	52	as	as	ADP
admet-1476	206	53	fassif	fassif	NOUN
admet-1476	206	54	blank	blank	VERB
admet-1476	206	55	and	and	CCONJ
admet-1476	206	56	fessif	fessif	NOUN
admet-1476	206	57	blank	blank	PROPN
admet-1476	206	58	)	)	PUNCT
admet-1476	206	59	.	.	PUNCT
admet-1476	207	1	a	a	DET
admet-1476	207	2	representative	representative	ADJ
admet-1476	207	3	dissolution	dissolution	NOUN
admet-1476	207	4	profile	profile	NOUN
admet-1476	207	5	for	for	ADP
admet-1476	207	6	40	40	NUM
admet-1476	207	7	mg	mg	PROPN
admet-1476	207	8	dose	dose	NOUN
admet-1476	207	9	has	have	AUX
admet-1476	207	10	been	be	AUX
admet-1476	207	11	depicted	depict	VERB
admet-1476	207	12	in	in	ADP
admet-1476	207	13	figure	figure	NOUN
admet-1476	207	14	s10	s10	NOUN
admet-1476	207	15	;	;	PUNCT
admet-1476	207	16	supporting	support	VERB
admet-1476	207	17	information	information	NOUN
admet-1476	207	18	.	.	PUNCT
admet-1476	208	1	flux	flux	NOUN
admet-1476	208	2	values	value	NOUN
admet-1476	208	3	in	in	ADP
admet-1476	208	4	the	the	DET
admet-1476	208	5	fessif	fessif	PROPN
admet-1476	208	6	blank	blank	PROPN
admet-1476	208	7	are	be	AUX
admet-1476	208	8	higher	high	ADJ
admet-1476	208	9	at	at	ADP
admet-1476	208	10	all	all	DET
admet-1476	208	11	doses	dose	NOUN
admet-1476	208	12	comparing	compare	VERB
admet-1476	208	13	to	to	PART
admet-1476	208	14	flux	flux	VERB
admet-1476	208	15	in	in	ADP
admet-1476	208	16	the	the	DET
admet-1476	208	17	corresponding	corresponding	ADJ
admet-1476	208	18	biorelevant	biorelevant	NOUN
admet-1476	208	19	medium	medium	NOUN
admet-1476	208	20	.	.	PUNCT
admet-1476	209	1	this	this	PRON
admet-1476	209	2	suggests	suggest	VERB
admet-1476	209	3	that	that	SCONJ
admet-1476	209	4	fxt	fxt	PROPN
admet-1476	209	5	is	be	AUX
admet-1476	209	6	likely	likely	ADJ
admet-1476	209	7	to	to	PART
admet-1476	209	8	form	form	VERB
admet-1476	209	9	micelles	micelle	NOUN
admet-1476	209	10	with	with	ADP
admet-1476	209	11	biorelevant	biorelevant	NOUN
admet-1476	209	12	`	`	PUNCT
admet-1476	209	13	components	component	NOUN
admet-1476	209	14	(	(	PUNCT
admet-1476	209	15	lecithin	lecithin	NOUN
admet-1476	209	16	and	and	CCONJ
admet-1476	209	17	bile	bile	NOUN
admet-1476	209	18	)	)	PUNCT
admet-1476	209	19	of	of	ADP
admet-1476	209	20	fessif	fessif	NOUN
admet-1476	209	21	.	.	PUNCT
admet-1476	210	1	since	since	SCONJ
admet-1476	210	2	only	only	ADV
admet-1476	210	3	unbound	unbound	NOUN
admet-1476	210	4	form	form	NOUN
admet-1476	210	5	of	of	ADP
admet-1476	210	6	compound	compound	NOUN
admet-1476	210	7	can	can	AUX
admet-1476	210	8	permeate	permeate	VERB
admet-1476	210	9	through	through	ADP
admet-1476	210	10	the	the	DET
admet-1476	210	11	lipophilic	lipophilic	ADJ
admet-1476	210	12	barrier	barrier	NOUN
admet-1476	210	13	,	,	PUNCT
admet-1476	210	14	the	the	DET
admet-1476	210	15	higher	high	ADJ
admet-1476	210	16	flux	flux	NOUN
admet-1476	210	17	is	be	AUX
admet-1476	210	18	observed	observe	VERB
admet-1476	210	19	in	in	ADP
admet-1476	210	20	fessif	fessif	NOUN
admet-1476	210	21	blank	blank	VERB
admet-1476	210	22	where	where	SCONJ
admet-1476	210	23	concentration	concentration	NOUN
admet-1476	210	24	of	of	ADP
admet-1476	210	25	unbound	unbound	NOUN
admet-1476	210	26	fraction	fraction	NOUN
admet-1476	210	27	is	be	AUX
admet-1476	210	28	higher	high	ADJ
admet-1476	210	29	in	in	ADP
admet-1476	210	30	the	the	DET
admet-1476	210	31	absence	absence	NOUN
admet-1476	210	32	of	of	ADP
admet-1476	210	33	lecithin	lecithin	NOUN
admet-1476	210	34	and	and	CCONJ
admet-1476	210	35	sodium	sodium	NOUN
admet-1476	210	36	taurocholate	taurocholate	NOUN
admet-1476	210	37	.	.	PUNCT
admet-1476	211	1	the	the	DET
admet-1476	211	2	dissolution	dissolution	NOUN
admet-1476	211	3	and	and	CCONJ
admet-1476	211	4	appearance	appearance	NOUN
admet-1476	211	5	kinetics	kinetic	NOUN
admet-1476	211	6	(	(	PUNCT
admet-1476	211	7	in	in	ADP
admet-1476	211	8	receiver	receiver	ADJ
admet-1476	211	9	compartment	compartment	NOUN
admet-1476	211	10	)	)	PUNCT
admet-1476	211	11	of	of	ADP
admet-1476	211	12	fxt	fxt	PROPN
admet-1476	211	13	in	in	ADP
admet-1476	211	14	flux	flux	NOUN
admet-1476	211	15	experiments	experiment	NOUN
admet-1476	211	16	conducted	conduct	VERB
admet-1476	211	17	at	at	ADP
admet-1476	211	18	the	the	DET
admet-1476	211	19	fasted	fasted	ADJ
admet-1476	211	20	state	state	NOUN
admet-1476	211	21	depends	depend	VERB
admet-1476	211	22	on	on	ADP
admet-1476	211	23	dose	dose	PROPN
admet-1476	211	24	.	.	PUNCT
admet-1476	212	1	while	while	SCONJ
admet-1476	212	2	at	at	ADP
admet-1476	212	3	the	the	DET
admet-1476	212	4	dose	dose	NOUN
admet-1476	212	5	equivalent	equivalent	NOUN
admet-1476	212	6	20	20	NUM
admet-1476	212	7	mg	mg	ADP
admet-1476	212	8	of	of	ADP
admet-1476	212	9	free	free	ADJ
admet-1476	212	10	base	base	NOUN
admet-1476	212	11	the	the	DET
admet-1476	212	12	appearance	appearance	NOUN
admet-1476	212	13	rate	rate	NOUN
admet-1476	212	14	is	be	AUX
admet-1476	212	15	linear	linear	ADJ
admet-1476	212	16	in	in	ADP
admet-1476	212	17	fassif	fassif	NOUN
admet-1476	212	18	and	and	CCONJ
admet-1476	212	19	fassif	fassif	NOUN
admet-1476	212	20	blank	blank	VERB
admet-1476	212	21	,	,	PUNCT
admet-1476	212	22	at	at	ADP
admet-1476	212	23	the	the	DET
admet-1476	212	24	dose	dose	NOUN
admet-1476	212	25	equivalent	equivalent	NOUN
admet-1476	212	26	200	200	NUM
admet-1476	212	27	mg	mg	NOUN
admet-1476	212	28	of	of	ADP
admet-1476	212	29	free	free	ADJ
admet-1476	212	30	base	base	NOUN
admet-1476	212	31	the	the	DET
admet-1476	212	32	flux	flux	NOUN
admet-1476	212	33	is	be	AUX
admet-1476	212	34	significantly	significantly	ADV
admet-1476	212	35	reduced	reduce	VERB
admet-1476	212	36	in	in	ADP
admet-1476	212	37	fassif	fassif	NOUN
admet-1476	212	38	after	after	ADP
admet-1476	212	39	~	~	PUNCT
admet-1476	212	40	5	5	NUM
admet-1476	212	41	hours	hour	NOUN
admet-1476	212	42	duration	duration	NOUN
admet-1476	212	43	of	of	ADP
admet-1476	212	44	the	the	DET
admet-1476	212	45	experiment	experiment	NOUN
admet-1476	212	46	comparing	compare	VERB
admet-1476	212	47	to	to	ADP
admet-1476	212	48	fassif	fassif	NOUN
admet-1476	212	49	blank	blank	PROPN
admet-1476	212	50	(	(	PUNCT
admet-1476	212	51	figure	figure	NOUN
admet-1476	212	52	4	4	NUM
admet-1476	212	53	)	)	PUNCT
admet-1476	212	54	.	.	PUNCT
admet-1476	213	1	the	the	DET
admet-1476	213	2	observed	observe	VERB
admet-1476	213	3	reduction	reduction	NOUN
admet-1476	213	4	of	of	ADP
admet-1476	213	5	flux	flux	NOUN
admet-1476	213	6	in	in	ADP
admet-1476	213	7	the	the	DET
admet-1476	213	8	receivers	receiver	NOUN
admet-1476	213	9	,	,	PUNCT
admet-1476	213	10	correlates	correlate	VERB
admet-1476	213	11	with	with	ADP
admet-1476	213	12	decrease	decrease	NOUN
admet-1476	213	13	of	of	ADP
admet-1476	213	14	turbidity	turbidity	NOUN
admet-1476	213	15	and	and	CCONJ
admet-1476	213	16	haziness	haziness	NOUN
admet-1476	213	17	of	of	ADP
admet-1476	213	18	fassif	fassif	NOUN
admet-1476	213	19	admet	admet	PROPN
admet-1476	213	20	&	&	CCONJ
admet-1476	213	21	dmpk	dmpk	PROPN
admet-1476	213	22	10(4	10(4	NUM
admet-1476	213	23	)	)	PUNCT
admet-1476	213	24	(	(	PUNCT
admet-1476	213	25	2022	2022	NUM
admet-1476	213	26	)	)	PUNCT
admet-1476	213	27	299	299	NUM
admet-1476	213	28	-	-	SYM
admet-1476	213	29	314	314	NUM
admet-1476	213	30	material	material	NOUN
admet-1476	213	31	sparing	sparing	NOUN
admet-1476	213	32	µflux	µflux	NOUN
admet-1476	213	33	methodology	methodology	NOUN
admet-1476	213	34	doi	doi	NOUN
admet-1476	213	35	:	:	PUNCT
admet-1476	213	36	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	NOUN
admet-1476	213	37	309	309	NUM
admet-1476	213	38	medium	medium	NOUN
admet-1476	213	39	in	in	ADP
admet-1476	213	40	the	the	DET
admet-1476	213	41	corresponding	corresponding	ADJ
admet-1476	213	42	donor	donor	NOUN
admet-1476	213	43	compartments	compartment	NOUN
admet-1476	213	44	of	of	ADP
admet-1476	213	45	the	the	DET
admet-1476	213	46	µflux	µflux	NOUN
admet-1476	213	47	pairs	pair	NOUN
admet-1476	213	48	observed	observe	VERB
admet-1476	213	49	after	after	ADP
admet-1476	213	50	several	several	ADJ
admet-1476	213	51	hours	hour	NOUN
admet-1476	213	52	’	'	PUNCT
admet-1476	213	53	duration	duration	NOUN
admet-1476	213	54	of	of	ADP
admet-1476	213	55	the	the	DET
admet-1476	213	56	assay	assay	NOUN
admet-1476	213	57	.	.	PUNCT
admet-1476	214	1	simultaneously	simultaneously	ADV
admet-1476	214	2	,	,	PUNCT
admet-1476	214	3	spectra	spectra	NOUN
admet-1476	214	4	of	of	ADP
admet-1476	214	5	fxt	fxt	PROPN
admet-1476	214	6	in	in	ADP
admet-1476	214	7	fassif	fassif	NOUN
admet-1476	214	8	where	where	SCONJ
admet-1476	214	9	slowly	slowly	ADV
admet-1476	214	10	changing	change	VERB
admet-1476	214	11	from	from	ADP
admet-1476	214	12	its	its	PRON
admet-1476	214	13	original	original	ADJ
admet-1476	214	14	shape	shape	NOUN
admet-1476	214	15	making	make	VERB
admet-1476	214	16	quantification	quantification	NOUN
admet-1476	214	17	of	of	ADP
admet-1476	214	18	the	the	DET
admet-1476	214	19	sample	sample	NOUN
admet-1476	214	20	in	in	ADP
admet-1476	214	21	donors	donor	NOUN
admet-1476	214	22	inaccurate	inaccurate	ADJ
admet-1476	214	23	.	.	PUNCT
admet-1476	215	1	it	it	PRON
admet-1476	215	2	is	be	AUX
admet-1476	215	3	possible	possible	ADJ
admet-1476	215	4	to	to	PART
admet-1476	215	5	speculate	speculate	VERB
admet-1476	215	6	that	that	SCONJ
admet-1476	215	7	fxt	fxt	PROPN
admet-1476	215	8	forms	form	VERB
admet-1476	215	9	stronger	strong	ADJ
admet-1476	215	10	binding	bind	VERB
admet-1476	215	11	with	with	ADP
admet-1476	215	12	the	the	DET
admet-1476	215	13	biorelevant	biorelevant	ADJ
admet-1476	215	14	components	component	NOUN
admet-1476	215	15	of	of	ADP
admet-1476	215	16	the	the	DET
admet-1476	215	17	medium	medium	NOUN
admet-1476	215	18	at	at	ADP
admet-1476	215	19	the	the	DET
admet-1476	215	20	later	later	ADJ
admet-1476	215	21	stages	stage	NOUN
admet-1476	215	22	on	on	ADP
admet-1476	215	23	experiment	experiment	NOUN
admet-1476	215	24	comparing	compare	VERB
admet-1476	215	25	to	to	ADP
admet-1476	215	26	the	the	DET
admet-1476	215	27	initial	initial	ADJ
admet-1476	215	28	phase	phase	NOUN
admet-1476	215	29	.	.	PUNCT
admet-1476	216	1	figure	figure	NOUN
admet-1476	216	2	4	4	NUM
admet-1476	216	3	.	.	NOUN
admet-1476	216	4	appearance	appearance	NOUN
admet-1476	216	5	kinetic	kinetic	NOUN
admet-1476	216	6	of	of	ADP
admet-1476	216	7	fluoxetine	fluoxetine	NOUN
admet-1476	216	8	in	in	ADP
admet-1476	216	9	the	the	DET
admet-1476	216	10	receiver	receiver	ADJ
admet-1476	216	11	chambers	chamber	NOUN
admet-1476	216	12	during	during	ADP
admet-1476	216	13	µflux	µflux	NOUN
admet-1476	216	14	experiment	experiment	NOUN
admet-1476	216	15	at	at	ADP
admet-1476	216	16	dose	dose	NOUN
admet-1476	216	17	equivalent	equivalent	ADJ
admet-1476	216	18	to	to	ADP
admet-1476	216	19	200	200	NUM
admet-1476	216	20	mg	mg	NOUN
admet-1476	216	21	of	of	ADP
admet-1476	216	22	free	free	ADJ
admet-1476	216	23	base	base	NOUN
admet-1476	216	24	.	.	PUNCT
admet-1476	217	1	the	the	DET
admet-1476	217	2	corresponding	correspond	VERB
admet-1476	217	3	donor	donor	NOUN
admet-1476	217	4	chambers	chamber	NOUN
admet-1476	217	5	of	of	ADP
admet-1476	217	6	µflux	µflux	NOUN
admet-1476	217	7	pairs	pair	NOUN
admet-1476	217	8	were	be	AUX
admet-1476	217	9	filled	fill	VERB
admet-1476	217	10	with	with	ADP
admet-1476	217	11	fassif	fassif	NOUN
admet-1476	217	12	and	and	CCONJ
admet-1476	217	13	fassif	fassif	VERB
admet-1476	217	14	blank	blank	ADJ
admet-1476	217	15	media	medium	NOUN
admet-1476	217	16	.	.	PUNCT
admet-1476	218	1	fed	fed	PROPN
admet-1476	218	2	/	/	SYM
admet-1476	218	3	fasted	fast	VERB
admet-1476	218	4	ratio	ratio	NOUN
admet-1476	218	5	0.5	0.5	NUM
admet-1476	218	6	calculated	calculate	VERB
admet-1476	218	7	based	base	VERB
admet-1476	218	8	on	on	ADP
admet-1476	218	9	the	the	DET
admet-1476	218	10	flux	flux	NOUN
admet-1476	218	11	data	datum	NOUN
admet-1476	218	12	in	in	ADP
admet-1476	218	13	biorelevant	biorelevant	ADJ
admet-1476	218	14	media	medium	NOUN
admet-1476	218	15	indicates	indicate	VERB
admet-1476	218	16	negative	negative	ADJ
admet-1476	218	17	food	food	NOUN
admet-1476	218	18	effect	effect	NOUN
admet-1476	218	19	at	at	ADP
admet-1476	218	20	all	all	DET
admet-1476	218	21	doses	dose	NOUN
admet-1476	218	22	except	except	SCONJ
admet-1476	218	23	dose	dose	NOUN
admet-1476	218	24	equivalent	equivalent	ADJ
admet-1476	218	25	200	200	NUM
admet-1476	218	26	mg	mg	NOUN
admet-1476	218	27	at	at	ADP
admet-1476	218	28	the	the	DET
admet-1476	218	29	late	late	ADJ
admet-1476	218	30	stage	stage	NOUN
admet-1476	218	31	of	of	ADP
admet-1476	218	32	experiments	experiment	NOUN
admet-1476	218	33	.	.	PUNCT
admet-1476	219	1	at	at	ADP
admet-1476	219	2	200	200	NUM
admet-1476	219	3	mg	mg	PROPN
admet-1476	219	4	dose	dose	PROPN
admet-1476	219	5	,	,	PUNCT
admet-1476	219	6	the	the	DET
admet-1476	219	7	fed	fed	PROPN
admet-1476	219	8	/	/	SYM
admet-1476	219	9	fasted	fast	VERB
admet-1476	219	10	ratio	ratio	NOUN
admet-1476	219	11	increases	increase	VERB
admet-1476	219	12	up	up	ADV
admet-1476	219	13	to	to	PART
admet-1476	219	14	7	7	NUM
admet-1476	219	15	due	due	ADP
admet-1476	219	16	to	to	ADP
admet-1476	219	17	suppression	suppression	NOUN
admet-1476	219	18	of	of	ADP
admet-1476	219	19	flux	flux	NOUN
admet-1476	219	20	in	in	ADP
admet-1476	219	21	fassif	fassif	NOUN
admet-1476	219	22	.	.	PUNCT
admet-1476	220	1	fed	fed	PROPN
admet-1476	220	2	/	/	SYM
admet-1476	220	3	fasted	fast	VERB
admet-1476	220	4	ratio	ratio	NOUN
admet-1476	220	5	obtained	obtain	VERB
admet-1476	220	6	in	in	ADP
admet-1476	220	7	the	the	DET
admet-1476	220	8	corresponding	corresponding	ADJ
admet-1476	220	9	blank	blank	ADJ
admet-1476	220	10	media	medium	NOUN
admet-1476	220	11	in	in	ADP
admet-1476	220	12	the	the	DET
admet-1476	220	13	absence	absence	NOUN
admet-1476	220	14	of	of	ADP
admet-1476	220	15	lecithin	lecithin	NOUN
admet-1476	220	16	and	and	CCONJ
admet-1476	220	17	bile	bile	NOUN
admet-1476	220	18	shows	show	VERB
admet-1476	220	19	ratios	ratio	NOUN
admet-1476	220	20	1.0	1.0	NUM
admet-1476	220	21	(	(	PUNCT
admet-1476	220	22	no	no	DET
admet-1476	220	23	food	food	NOUN
admet-1476	220	24	effect	effect	NOUN
admet-1476	220	25	)	)	PUNCT
admet-1476	220	26	and	and	CCONJ
admet-1476	220	27	0.5	0.5	NUM
admet-1476	220	28	(	(	PUNCT
admet-1476	220	29	negative	negative	ADJ
admet-1476	220	30	food	food	NOUN
admet-1476	220	31	effect	effect	NOUN
admet-1476	220	32	)	)	PUNCT
admet-1476	220	33	at	at	ADP
admet-1476	220	34	20	20	NUM
admet-1476	220	35	mg	mg	NOUN
admet-1476	220	36	and	and	CCONJ
admet-1476	220	37	200	200	NUM
admet-1476	220	38	mg	mg	NOUN
admet-1476	220	39	dose	dose	NOUN
admet-1476	220	40	equivalent	equivalent	NOUN
admet-1476	220	41	correspondingly	correspondingly	ADV
admet-1476	220	42	.	.	PUNCT
admet-1476	221	1	generally	generally	ADV
admet-1476	221	2	,	,	PUNCT
admet-1476	221	3	for	for	ADP
admet-1476	221	4	bcs	bc	NOUN
admet-1476	221	5	i	i	PRON
admet-1476	221	6	drugs	drug	NOUN
admet-1476	221	7	,	,	PUNCT
admet-1476	221	8	irrespective	irrespective	ADV
admet-1476	221	9	of	of	ADP
admet-1476	221	10	the	the	DET
admet-1476	221	11	prandial	prandial	ADJ
admet-1476	221	12	state	state	NOUN
admet-1476	221	13	,	,	PUNCT
admet-1476	221	14	the	the	DET
admet-1476	221	15	drugs	drug	NOUN
admet-1476	221	16	are	be	AUX
admet-1476	221	17	completely	completely	ADV
admet-1476	221	18	absorbed	absorb	VERB
admet-1476	221	19	and	and	CCONJ
admet-1476	221	20	hence	hence	ADV
admet-1476	221	21	exhibit	exhibit	VERB
admet-1476	221	22	no	no	DET
admet-1476	221	23	fe	fe	NOUN
admet-1476	221	24	.	.	PUNCT
admet-1476	222	1	therefore	therefore	ADV
admet-1476	222	2	,	,	PUNCT
admet-1476	222	3	the	the	DET
admet-1476	222	4	fe	fe	NOUN
admet-1476	222	5	prediction	prediction	NOUN
admet-1476	222	6	based	base	VERB
admet-1476	222	7	on	on	ADP
admet-1476	222	8	the	the	DET
admet-1476	222	9	µflux	µflux	NOUN
admet-1476	222	10	method	method	NOUN
admet-1476	222	11	may	may	AUX
admet-1476	222	12	not	not	PART
admet-1476	222	13	be	be	AUX
admet-1476	222	14	reliable	reliable	ADJ
admet-1476	222	15	for	for	ADP
admet-1476	222	16	bcs	bc	NOUN
admet-1476	222	17	i	i	PRON
admet-1476	222	18	compounds	compound	VERB
admet-1476	222	19	.	.	PUNCT
admet-1476	223	1	zidovudine	zidovudine	PROPN
admet-1476	223	2	,	,	PUNCT
admet-1476	223	3	an	an	DET
admet-1476	223	4	anti	anti	ADJ
admet-1476	223	5	-	-	ADJ
admet-1476	223	6	hiv	hiv	ADJ
admet-1476	223	7	drug	drug	NOUN
admet-1476	223	8	,	,	PUNCT
admet-1476	223	9	falls	fall	VERB
admet-1476	223	10	in	in	ADP
admet-1476	223	11	bcs	bc	NOUN
admet-1476	223	12	-	-	PUNCT
admet-1476	223	13	iii	iii	NUM
admet-1476	223	14	category	category	NOUN
admet-1476	223	15	.	.	PUNCT
admet-1476	224	1	the	the	DET
admet-1476	224	2	compound	compound	NOUN
admet-1476	224	3	is	be	AUX
admet-1476	224	4	reported	report	VERB
admet-1476	224	5	to	to	PART
admet-1476	224	6	have	have	VERB
admet-1476	224	7	a	a	DET
admet-1476	224	8	negative	negative	ADJ
admet-1476	224	9	food	food	NOUN
admet-1476	224	10	effect	effect	NOUN
admet-1476	224	11	[	[	X
admet-1476	224	12	42	42	NUM
admet-1476	224	13	]	]	PUNCT
admet-1476	224	14	.	.	PUNCT
admet-1476	225	1	but	but	CCONJ
admet-1476	225	2	looking	look	VERB
admet-1476	225	3	at	at	ADP
admet-1476	225	4	the	the	DET
admet-1476	225	5	pk	pk	NOUN
admet-1476	225	6	data	datum	NOUN
admet-1476	225	7	,	,	PUNCT
admet-1476	225	8	the	the	DET
admet-1476	225	9	fed	fed	PROPN
admet-1476	225	10	/	/	SYM
admet-1476	225	11	fasting	fast	VERB
admet-1476	225	12	auc	auc	ADJ
admet-1476	225	13	ratio	ratio	NOUN
admet-1476	225	14	is	be	AUX
admet-1476	225	15	0.9	0.9	NUM
admet-1476	225	16	,	,	PUNCT
admet-1476	225	17	and	and	CCONJ
admet-1476	225	18	that	that	PRON
admet-1476	225	19	is	be	AUX
admet-1476	225	20	well	well	ADV
admet-1476	225	21	within	within	ADP
admet-1476	225	22	the	the	DET
admet-1476	225	23	range	range	NOUN
admet-1476	225	24	of	of	ADP
admet-1476	225	25	bioequivalence	bioequivalence	NOUN
admet-1476	225	26	,	,	PUNCT
admet-1476	225	27	as	as	SCONJ
admet-1476	225	28	defined	define	VERB
admet-1476	225	29	by	by	ADP
admet-1476	225	30	fda	fda	PROPN
admet-1476	225	31	.	.	PUNCT
admet-1476	226	1	on	on	ADP
admet-1476	226	2	the	the	DET
admet-1476	226	3	other	other	ADJ
admet-1476	226	4	hand	hand	NOUN
admet-1476	226	5	,	,	PUNCT
admet-1476	226	6	the	the	DET
admet-1476	226	7	ratio	ratio	NOUN
admet-1476	226	8	of	of	ADP
admet-1476	226	9	cmax	cmax	NOUN
admet-1476	226	10	between	between	ADP
admet-1476	226	11	fed	fed	PROPN
admet-1476	226	12	and	and	CCONJ
admet-1476	226	13	fasting	fasting	NOUN
admet-1476	226	14	was	be	AUX
admet-1476	226	15	0.3	0.3	NUM
admet-1476	226	16	.	.	PUNCT
admet-1476	227	1	the	the	DET
admet-1476	227	2	flux	flux	NOUN
admet-1476	227	3	ratio	ratio	NOUN
admet-1476	227	4	between	between	ADP
admet-1476	227	5	fed	fed	PROPN
admet-1476	227	6	and	and	CCONJ
admet-1476	227	7	fasting	fast	VERB
admet-1476	227	8	state	state	NOUN
admet-1476	227	9	was	be	AUX
admet-1476	227	10	determined	determine	VERB
admet-1476	227	11	to	to	PART
admet-1476	227	12	be	be	AUX
admet-1476	227	13	0.92	0.92	NUM
admet-1476	227	14	indicating	indicate	VERB
admet-1476	227	15	no	no	DET
admet-1476	227	16	food	food	NOUN
admet-1476	227	17	effect	effect	NOUN
admet-1476	227	18	(	(	PUNCT
admet-1476	227	19	figure	figure	NOUN
admet-1476	227	20	s7	s7	NOUN
admet-1476	227	21	;	;	PUNCT
admet-1476	227	22	supporting	support	VERB
admet-1476	227	23	information	information	NOUN
admet-1476	227	24	)	)	PUNCT
admet-1476	227	25	.	.	PUNCT
admet-1476	228	1	the	the	DET
admet-1476	228	2	reason	reason	NOUN
admet-1476	228	3	for	for	ADP
admet-1476	228	4	this	this	DET
admet-1476	228	5	discrepancy	discrepancy	NOUN
admet-1476	228	6	might	might	AUX
admet-1476	228	7	be	be	AUX
admet-1476	228	8	due	due	ADJ
admet-1476	228	9	to	to	AUX
admet-1476	228	10	reported	report	VERB
admet-1476	228	11	delayed	delay	VERB
admet-1476	228	12	gastric	gastric	ADJ
admet-1476	228	13	emptying	empty	VERB
admet-1476	228	14	in	in	ADP
admet-1476	228	15	fed	fed	PROPN
admet-1476	228	16	state	state	NOUN
admet-1476	228	17	[	[	X
admet-1476	228	18	42	42	NUM
admet-1476	228	19	]	]	PUNCT
admet-1476	228	20	.	.	PUNCT
admet-1476	229	1	the	the	DET
admet-1476	229	2	delayed	delay	VERB
admet-1476	229	3	gastric	gastric	ADJ
admet-1476	229	4	emptying	empty	VERB
admet-1476	229	5	might	might	AUX
admet-1476	229	6	be	be	AUX
admet-1476	229	7	responsible	responsible	ADJ
admet-1476	229	8	for	for	ADP
admet-1476	229	9	the	the	DET
admet-1476	229	10	lower	low	ADJ
admet-1476	229	11	cmax	cmax	NOUN
admet-1476	229	12	in	in	ADP
admet-1476	229	13	the	the	DET
admet-1476	229	14	fed	fed	PROPN
admet-1476	229	15	state	state	NOUN
admet-1476	229	16	,	,	PUNCT
admet-1476	229	17	but	but	CCONJ
admet-1476	229	18	almost	almost	ADV
admet-1476	229	19	no	no	PRON
admet-1476	229	20	change	change	NOUN
admet-1476	229	21	in	in	ADP
admet-1476	229	22	auc	auc	NOUN
admet-1476	229	23	.	.	PUNCT
admet-1476	230	1	unfortunately	unfortunately	ADV
admet-1476	230	2	,	,	PUNCT
admet-1476	230	3	in	in	ADP
admet-1476	230	4	vitro	vitro	X
admet-1476	230	5	flux	flux	PROPN
admet-1476	230	6	measurement	measurement	NOUN
admet-1476	230	7	can	can	AUX
admet-1476	230	8	not	not	PART
admet-1476	230	9	predict	predict	VERB
admet-1476	230	10	the	the	DET
admet-1476	230	11	change	change	NOUN
admet-1476	230	12	in	in	ADP
admet-1476	230	13	the	the	DET
admet-1476	230	14	physiology	physiology	NOUN
admet-1476	230	15	due	due	ADP
admet-1476	230	16	to	to	ADP
admet-1476	230	17	the	the	DET
admet-1476	230	18	presence	presence	NOUN
admet-1476	230	19	of	of	ADP
admet-1476	230	20	food	food	NOUN
admet-1476	230	21	.	.	PUNCT
admet-1476	231	1	for	for	ADP
admet-1476	231	2	clopidogrel	clopidogrel	NOUN
admet-1476	231	3	bisulfate	bisulfate	NOUN
admet-1476	231	4	[	[	X
admet-1476	231	5	43	43	NUM
admet-1476	231	6	]	]	PUNCT
admet-1476	231	7	and	and	CCONJ
admet-1476	231	8	nifedipine	nifedipine	NOUN
admet-1476	232	1	[	[	X
admet-1476	232	2	44	44	NUM
admet-1476	232	3	]	]	PUNCT
admet-1476	232	4	,	,	PUNCT
admet-1476	232	5	the	the	DET
admet-1476	232	6	solubility	solubility	NOUN
admet-1476	232	7	ratio	ratio	NOUN
admet-1476	232	8	(	(	PUNCT
admet-1476	232	9	fed	fed	PROPN
admet-1476	232	10	/	/	SYM
admet-1476	232	11	fasted	fast	VERB
admet-1476	232	12	)	)	PUNCT
admet-1476	232	13	was	be	AUX
admet-1476	232	14	found	find	VERB
admet-1476	232	15	to	to	PART
admet-1476	232	16	be	be	AUX
admet-1476	232	17	3.85	3.85	NUM
admet-1476	232	18	and	and	CCONJ
admet-1476	232	19	3.2	3.2	NUM
admet-1476	232	20	,	,	PUNCT
admet-1476	232	21	respectively	respectively	ADV
admet-1476	232	22	.	.	PUNCT
admet-1476	233	1	if	if	SCONJ
admet-1476	233	2	one	one	PRON
admet-1476	233	3	goes	go	VERB
admet-1476	233	4	by	by	ADP
admet-1476	233	5	the	the	DET
admet-1476	233	6	solubility	solubility	NOUN
admet-1476	233	7	data	datum	NOUN
admet-1476	233	8	alone	alone	ADV
admet-1476	233	9	,	,	PUNCT
admet-1476	233	10	both	both	CCONJ
admet-1476	233	11	the	the	DET
admet-1476	233	12	compounds	compound	NOUN
admet-1476	233	13	were	be	AUX
admet-1476	233	14	expected	expect	VERB
admet-1476	233	15	to	to	PART
admet-1476	233	16	show	show	VERB
admet-1476	233	17	a	a	DET
admet-1476	233	18	positive	positive	ADJ
admet-1476	233	19	food	food	NOUN
admet-1476	233	20	effect	effect	NOUN
admet-1476	233	21	.	.	PUNCT
admet-1476	234	1	but	but	CCONJ
admet-1476	234	2	the	the	DET
admet-1476	234	3	clinical	clinical	ADJ
admet-1476	234	4	data	datum	NOUN
admet-1476	234	5	reported	report	VERB
admet-1476	234	6	no	no	DET
admet-1476	234	7	food	food	NOUN
admet-1476	234	8	effect	effect	NOUN
admet-1476	234	9	in	in	ADP
admet-1476	234	10	both	both	CCONJ
admet-1476	234	11	the	the	DET
admet-1476	234	12	cases	case	NOUN
admet-1476	234	13	.	.	PUNCT
admet-1476	235	1	for	for	ADP
admet-1476	235	2	clopidogrel	clopidogrel	NOUN
admet-1476	235	3	bisulfate	bisulfate	NOUN
admet-1476	235	4	and	and	CCONJ
admet-1476	235	5	nifedipine	nifedipine	NOUN
admet-1476	235	6	,	,	PUNCT
admet-1476	235	7	the	the	DET
admet-1476	235	8	flux	flux	NOUN
admet-1476	235	9	ratio	ratio	NOUN
admet-1476	235	10	(	(	PUNCT
admet-1476	235	11	fed	fed	PROPN
admet-1476	235	12	/	/	SYM
admet-1476	235	13	fasted	fast	VERB
admet-1476	235	14	)	)	PUNCT
admet-1476	235	15	was	be	AUX
admet-1476	235	16	determined	determine	VERB
admet-1476	235	17	to	to	PART
admet-1476	235	18	be	be	AUX
admet-1476	235	19	1.24	1.24	NUM
admet-1476	235	20	and	and	CCONJ
admet-1476	235	21	1.01	1.01	NUM
admet-1476	235	22	,	,	PUNCT
admet-1476	235	23	respectively	respectively	ADV
admet-1476	235	24	(	(	PUNCT
admet-1476	235	25	table	table	NOUN
admet-1476	235	26	3	3	NUM
admet-1476	235	27	)	)	PUNCT
admet-1476	235	28	.	.	PUNCT
admet-1476	236	1	in	in	ADP
admet-1476	236	2	both	both	CCONJ
admet-1476	236	3	the	the	DET
admet-1476	236	4	cases	case	NOUN
admet-1476	236	5	,	,	PUNCT
admet-1476	236	6	flux	flux	PROPN
admet-1476	236	7	ratio	ratio	NOUN
admet-1476	236	8	predicted	predict	VERB
admet-1476	236	9	no	no	DET
admet-1476	236	10	food	food	NOUN
admet-1476	236	11	effect	effect	NOUN
admet-1476	236	12	and	and	CCONJ
admet-1476	236	13	agreed	agree	VERB
admet-1476	236	14	with	with	ADP
admet-1476	236	15	the	the	DET
admet-1476	236	16	clinical	clinical	ADJ
admet-1476	236	17	results	result	NOUN
admet-1476	236	18	(	(	PUNCT
admet-1476	236	19	figure	figure	NOUN
admet-1476	236	20	s8	s8	NOUN
admet-1476	236	21	and	and	CCONJ
admet-1476	236	22	s9	s9	NOUN
admet-1476	236	23	;	;	PUNCT
admet-1476	236	24	supporting	support	VERB
admet-1476	236	25	information	information	NOUN
admet-1476	236	26	)	)	PUNCT
admet-1476	236	27	.	.	PUNCT
admet-1476	237	1	in	in	ADP
admet-1476	237	2	fed	fed	PROPN
admet-1476	237	3	state	state	PROPN
admet-1476	237	4	,	,	PUNCT
admet-1476	237	5	the	the	DET
admet-1476	237	6	micelles	micelle	NOUN
admet-1476	237	7	and	and	CCONJ
admet-1476	237	8	colloidal	colloidal	NOUN
admet-1476	237	9	species	specie	NOUN
admet-1476	237	10	formed	form	VERB
admet-1476	237	11	by	by	ADP
admet-1476	237	12	bile	bile	NOUN
admet-1476	237	13	salts	salt	NOUN
admet-1476	237	14	and	and	CCONJ
admet-1476	237	15	lecithin	lecithin	NOUN
admet-1476	237	16	might	might	AUX
admet-1476	237	17	have	have	AUX
admet-1476	237	18	helped	help	VERB
admet-1476	237	19	in	in	ADP
admet-1476	237	20	solubilization	solubilization	NOUN
admet-1476	237	21	of	of	ADP
admet-1476	237	22	these	these	DET
admet-1476	237	23	two	two	NUM
admet-1476	237	24	insoluble	insoluble	ADJ
admet-1476	237	25	drugs	drug	NOUN
admet-1476	237	26	.	.	PUNCT
admet-1476	238	1	the	the	DET
admet-1476	238	2	drug	drug	NOUN
admet-1476	238	3	molecules	molecule	NOUN
admet-1476	238	4	may	may	AUX
admet-1476	238	5	form	form	VERB
admet-1476	238	6	a	a	DET
admet-1476	238	7	complex	complex	NOUN
admet-1476	238	8	with	with	ADP
admet-1476	238	9	bile	bile	NOUN
admet-1476	238	10	salts	salt	NOUN
admet-1476	238	11	0	0	NUM
admet-1476	239	1	50	50	NUM
admet-1476	239	2	100	100	NUM
admet-1476	239	3	150	150	NUM
admet-1476	239	4	200	200	NUM
admet-1476	239	5	250	250	NUM
admet-1476	239	6	0	0	NUM
admet-1476	239	7	100	100	NUM
admet-1476	239	8	200	200	NUM
admet-1476	239	9	300	300	NUM
admet-1476	239	10	400	400	NUM
admet-1476	239	11	500	500	NUM
admet-1476	239	12	c	c	NOUN
admet-1476	239	13	o	o	PROPN
admet-1476	239	14	n	n	X
admet-1476	239	15	ce	ce	PROPN
admet-1476	239	16	n	n	CCONJ
admet-1476	239	17	tr	tr	VERB
admet-1476	239	18	a	a	DET
admet-1476	239	19	ti	ti	NOUN
admet-1476	239	20	o	o	NOUN
admet-1476	239	21	n	n	PROPN
admet-1476	239	22	(	(	PUNCT
admet-1476	239	23	µ	µ	X
admet-1476	239	24	g	g	NOUN
admet-1476	239	25	/m	/m	SYM
admet-1476	239	26	l	l	NOUN
admet-1476	239	27	)	)	PUNCT
admet-1476	239	28	time	time	NOUN
admet-1476	239	29	(	(	PUNCT
admet-1476	239	30	min	min	NOUN
admet-1476	239	31	)	)	PUNCT
admet-1476	239	32	fassif	fassif	VERB
admet-1476	239	33	fassif	fassif	NOUN
admet-1476	239	34	-	-	PUNCT
admet-1476	239	35	blank	blank	VERB
admet-1476	239	36	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	PROPN
admet-1476	239	37	c.	c.	PROPN
admet-1476	239	38	jankovsky	jankovsky	PROPN
admet-1476	239	39	et	et	PROPN
admet-1476	239	40	al	al	PROPN
admet-1476	239	41	.	.	PROPN
admet-1476	239	42	admet	admet	PROPN
admet-1476	239	43	&	&	CCONJ
admet-1476	239	44	dmpk	dmpk	PROPN
admet-1476	239	45	10(4	10(4	NUM
admet-1476	239	46	)	)	PUNCT
admet-1476	239	47	(	(	PUNCT
admet-1476	239	48	2022	2022	NUM
admet-1476	239	49	)	)	PUNCT
admet-1476	239	50	299	299	NUM
admet-1476	239	51	-	-	SYM
admet-1476	239	52	314	314	NUM
admet-1476	239	53	310	310	NUM
admet-1476	239	54	or	or	CCONJ
admet-1476	239	55	might	might	AUX
admet-1476	239	56	get	get	AUX
admet-1476	239	57	“	"	PUNCT
admet-1476	239	58	entrapped	entrap	VERB
admet-1476	239	59	”	"	PUNCT
admet-1476	239	60	into	into	ADP
admet-1476	239	61	the	the	DET
admet-1476	239	62	micellar	micellar	ADJ
admet-1476	239	63	core	core	NOUN
admet-1476	239	64	.	.	PUNCT
admet-1476	240	1	as	as	SCONJ
admet-1476	240	2	only	only	ADV
admet-1476	240	3	the	the	DET
admet-1476	240	4	free	free	ADJ
admet-1476	240	5	drug	drug	NOUN
admet-1476	240	6	molecules	molecule	NOUN
admet-1476	240	7	in	in	ADP
admet-1476	240	8	solution	solution	NOUN
admet-1476	240	9	(	(	PUNCT
admet-1476	240	10	unbound	unbound	NOUN
admet-1476	240	11	form	form	NOUN
admet-1476	240	12	)	)	PUNCT
admet-1476	240	13	of	of	ADP
admet-1476	240	14	the	the	DET
admet-1476	240	15	drug	drug	NOUN
admet-1476	240	16	is	be	AUX
admet-1476	240	17	available	available	ADJ
admet-1476	240	18	for	for	ADP
admet-1476	240	19	the	the	DET
admet-1476	240	20	absorption	absorption	NOUN
admet-1476	240	21	through	through	ADP
admet-1476	240	22	the	the	DET
admet-1476	240	23	epithelial	epithelial	ADJ
admet-1476	240	24	membrane	membrane	NOUN
admet-1476	240	25	,	,	PUNCT
admet-1476	240	26	the	the	DET
admet-1476	240	27	total	total	ADJ
admet-1476	240	28	drug	drug	NOUN
admet-1476	240	29	solubility	solubility	NOUN
admet-1476	240	30	may	may	AUX
admet-1476	240	31	not	not	PART
admet-1476	240	32	be	be	AUX
admet-1476	240	33	a	a	DET
admet-1476	240	34	reliable	reliable	ADJ
admet-1476	240	35	way	way	NOUN
admet-1476	240	36	to	to	PART
admet-1476	240	37	predict	predict	VERB
admet-1476	240	38	the	the	DET
admet-1476	240	39	food	food	NOUN
admet-1476	240	40	effect	effect	NOUN
admet-1476	240	41	.	.	PUNCT
admet-1476	241	1	this	this	PRON
admet-1476	241	2	clearly	clearly	ADV
admet-1476	241	3	exhibits	exhibit	VERB
admet-1476	241	4	that	that	SCONJ
admet-1476	241	5	in	in	ADP
admet-1476	241	6	addition	addition	NOUN
admet-1476	241	7	to	to	ADP
admet-1476	241	8	the	the	DET
admet-1476	241	9	drug	drug	NOUN
admet-1476	241	10	dissolution	dissolution	NOUN
admet-1476	241	11	in	in	ADP
admet-1476	241	12	biorelevant	biorelevant	ADJ
admet-1476	241	13	media	medium	NOUN
admet-1476	241	14	,	,	PUNCT
admet-1476	241	15	the	the	DET
admet-1476	241	16	evaluation	evaluation	NOUN
admet-1476	241	17	of	of	ADP
admet-1476	241	18	the	the	DET
admet-1476	241	19	diffusion	diffusion	NOUN
admet-1476	241	20	flux	flux	NOUN
admet-1476	241	21	where	where	SCONJ
admet-1476	241	22	only	only	ADV
admet-1476	241	23	the	the	DET
admet-1476	241	24	unbound	unbound	NOUN
admet-1476	241	25	drug	drug	NOUN
admet-1476	241	26	crosses	cross	VERB
admet-1476	241	27	the	the	DET
admet-1476	241	28	membrane	membrane	NOUN
admet-1476	241	29	,	,	PUNCT
admet-1476	241	30	is	be	AUX
admet-1476	241	31	more	more	ADV
admet-1476	241	32	reliable	reliable	ADJ
admet-1476	241	33	way	way	NOUN
admet-1476	241	34	to	to	PART
admet-1476	241	35	predict	predict	VERB
admet-1476	241	36	the	the	DET
admet-1476	241	37	food	food	NOUN
admet-1476	241	38	effect	effect	NOUN
admet-1476	241	39	.	.	PUNCT
admet-1476	242	1	for	for	ADP
admet-1476	242	2	a	a	DET
admet-1476	242	3	side	side	NOUN
admet-1476	242	4	-	-	PUNCT
admet-1476	242	5	by	by	ADP
admet-1476	242	6	-	-	PUNCT
admet-1476	242	7	side	side	NOUN
admet-1476	242	8	comparison	comparison	NOUN
admet-1476	242	9	of	of	ADP
admet-1476	242	10	the	the	DET
admet-1476	242	11	solubility	solubility	NOUN
admet-1476	242	12	ratio	ratio	NOUN
admet-1476	242	13	and	and	CCONJ
admet-1476	242	14	the	the	DET
admet-1476	242	15	flux	flux	NOUN
admet-1476	242	16	ratio	ratio	NOUN
admet-1476	242	17	to	to	ADP
admet-1476	242	18	the	the	DET
admet-1476	242	19	auc	auc	NOUN
admet-1476	242	20	ratio	ratio	NOUN
admet-1476	242	21	and	and	CCONJ
admet-1476	242	22	the	the	DET
admet-1476	242	23	cmax	cmax	NOUN
admet-1476	242	24	ratio	ratio	NOUN
admet-1476	242	25	for	for	ADP
admet-1476	242	26	the	the	DET
admet-1476	242	27	studied	study	VERB
admet-1476	242	28	compounds	compound	NOUN
admet-1476	242	29	,	,	PUNCT
admet-1476	242	30	a	a	DET
admet-1476	242	31	bar	bar	NOUN
admet-1476	242	32	graph	graph	NOUN
admet-1476	242	33	was	be	AUX
admet-1476	242	34	drawn	draw	VERB
admet-1476	242	35	(	(	PUNCT
admet-1476	242	36	figure	figure	NOUN
admet-1476	242	37	5	5	NUM
admet-1476	242	38	)	)	PUNCT
admet-1476	242	39	.	.	PUNCT
admet-1476	243	1	this	this	DET
admet-1476	243	2	graph	graph	NOUN
admet-1476	243	3	clearly	clearly	ADV
admet-1476	243	4	shows	show	VERB
admet-1476	243	5	that	that	SCONJ
admet-1476	243	6	the	the	DET
admet-1476	243	7	flux	flux	NOUN
admet-1476	243	8	ratio	ratio	NOUN
admet-1476	243	9	is	be	AUX
admet-1476	243	10	more	more	ADV
admet-1476	243	11	predictive	predictive	NOUN
admet-1476	243	12	of	of	ADP
admet-1476	243	13	fe	fe	NOUN
admet-1476	243	14	than	than	ADP
admet-1476	243	15	solubility	solubility	NOUN
admet-1476	243	16	ratio	ratio	NOUN
admet-1476	243	17	.	.	PUNCT
admet-1476	244	1	all	all	DET
admet-1476	244	2	compounds	compound	NOUN
admet-1476	244	3	that	that	PRON
admet-1476	244	4	exhibited	exhibit	VERB
admet-1476	244	5	a	a	DET
admet-1476	244	6	positive	positive	ADJ
admet-1476	244	7	fe	fe	NOUN
admet-1476	244	8	(	(	PUNCT
admet-1476	244	9	auc	auc	NOUN
admet-1476	244	10	ratio	ratio	NOUN
admet-1476	244	11	>	>	X
admet-1476	244	12	1	1	NUM
admet-1476	244	13	)	)	PUNCT
admet-1476	244	14	in	in	ADP
admet-1476	244	15	the	the	DET
admet-1476	244	16	clinic	clinic	NOUN
admet-1476	244	17	,	,	PUNCT
admet-1476	244	18	also	also	ADV
admet-1476	244	19	showed	show	VERB
admet-1476	244	20	a	a	DET
admet-1476	244	21	flux	flux	NOUN
admet-1476	244	22	ratio	ratio	NOUN
admet-1476	244	23	>	>	X
admet-1476	245	1	1	1	X
admet-1476	245	2	.	.	PUNCT
admet-1476	245	3	in	in	ADP
admet-1476	245	4	the	the	DET
admet-1476	245	5	case	case	NOUN
admet-1476	245	6	of	of	ADP
admet-1476	245	7	amiodarone	amiodarone	NOUN
admet-1476	245	8	,	,	PUNCT
admet-1476	245	9	the	the	DET
admet-1476	245	10	early	early	ADJ
admet-1476	245	11	time	time	NOUN
admet-1476	245	12	interval	interval	NOUN
admet-1476	245	13	flux	flux	NOUN
admet-1476	245	14	ratio	ratio	NOUN
admet-1476	245	15	(	(	PUNCT
admet-1476	245	16	4.25	4.25	NUM
admet-1476	245	17	)	)	PUNCT
admet-1476	245	18	was	be	AUX
admet-1476	245	19	predictive	predictive	ADJ
admet-1476	245	20	of	of	ADP
admet-1476	245	21	the	the	DET
admet-1476	245	22	initial	initial	ADJ
admet-1476	245	23	rate	rate	NOUN
admet-1476	245	24	of	of	ADP
admet-1476	245	25	absorption	absorption	NOUN
admet-1476	245	26	(	(	PUNCT
admet-1476	245	27	cmax	cmax	NOUN
admet-1476	245	28	3.68	3.68	NUM
admet-1476	245	29	)	)	PUNCT
admet-1476	245	30	while	while	SCONJ
admet-1476	245	31	the	the	DET
admet-1476	245	32	later	later	ADJ
admet-1476	245	33	time	time	NOUN
admet-1476	245	34	interval	interval	NOUN
admet-1476	245	35	flux	flux	NOUN
admet-1476	245	36	(	(	PUNCT
admet-1476	245	37	2.21	2.21	NUM
admet-1476	245	38	)	)	PUNCT
admet-1476	245	39	was	be	AUX
admet-1476	245	40	predictive	predictive	ADJ
admet-1476	245	41	of	of	ADP
admet-1476	245	42	the	the	DET
admet-1476	245	43	auc	auc	NOUN
admet-1476	245	44	ratio	ratio	NOUN
admet-1476	245	45	(	(	PUNCT
admet-1476	245	46	2.36	2.36	NUM
admet-1476	245	47	)	)	PUNCT
admet-1476	245	48	.	.	PUNCT
admet-1476	246	1	for	for	ADP
admet-1476	246	2	most	most	ADJ
admet-1476	246	3	of	of	ADP
admet-1476	246	4	the	the	DET
admet-1476	246	5	compounds	compound	NOUN
admet-1476	246	6	that	that	PRON
admet-1476	246	7	showed	show	VERB
admet-1476	246	8	auc	auc	NOUN
admet-1476	246	9	ratio	ratio	NOUN
admet-1476	246	10	≤	≤	NUM
admet-1476	246	11	1	1	NUM
admet-1476	246	12	,	,	PUNCT
admet-1476	246	13	the	the	DET
admet-1476	246	14	flux	flux	NOUN
admet-1476	246	15	ratio	ratio	NOUN
admet-1476	246	16	was	be	AUX
admet-1476	246	17	also	also	ADV
admet-1476	246	18	≤	≤	ADJ
admet-1476	246	19	1	1	NUM
admet-1476	246	20	.	.	PUNCT
admet-1476	246	21	figure	figure	NOUN
admet-1476	246	22	5	5	NUM
admet-1476	246	23	.	.	PUNCT
admet-1476	246	24	solubility	solubility	NOUN
admet-1476	246	25	ratio	ratio	NOUN
admet-1476	246	26	,	,	PUNCT
admet-1476	246	27	flux	flux	NOUN
admet-1476	246	28	ratio	ratio	NOUN
admet-1476	246	29	,	,	PUNCT
admet-1476	246	30	auc	auc	NOUN
admet-1476	246	31	ratio	ratio	NOUN
admet-1476	246	32	and	and	CCONJ
admet-1476	246	33	cmax	cmax	VERB
admet-1476	246	34	ratio	ratio	NOUN
admet-1476	246	35	for	for	ADP
admet-1476	246	36	the	the	DET
admet-1476	246	37	studied	study	VERB
admet-1476	246	38	compounds	compound	NOUN
admet-1476	246	39	during	during	ADP
admet-1476	246	40	the	the	DET
admet-1476	246	41	early	early	ADJ
admet-1476	246	42	stages	stage	NOUN
admet-1476	246	43	of	of	ADP
admet-1476	246	44	drug	drug	NOUN
admet-1476	246	45	development	development	NOUN
admet-1476	246	46	,	,	PUNCT
admet-1476	246	47	when	when	SCONJ
admet-1476	246	48	only	only	ADV
admet-1476	246	49	a	a	DET
admet-1476	246	50	small	small	ADJ
admet-1476	246	51	amount	amount	NOUN
admet-1476	246	52	of	of	ADP
admet-1476	246	53	drug	drug	NOUN
admet-1476	246	54	substance	substance	NOUN
admet-1476	246	55	(	(	PUNCT
admet-1476	246	56	ds	ds	NOUN
admet-1476	246	57	)	)	PUNCT
admet-1476	246	58	is	be	AUX
admet-1476	246	59	available	available	ADJ
admet-1476	246	60	,	,	PUNCT
admet-1476	246	61	scientists	scientist	NOUN
admet-1476	246	62	might	might	AUX
admet-1476	246	63	not	not	PART
admet-1476	246	64	be	be	AUX
admet-1476	246	65	aware	aware	ADJ
admet-1476	246	66	of	of	ADP
admet-1476	246	67	the	the	DET
admet-1476	246	68	mechanism	mechanism	NOUN
admet-1476	246	69	of	of	ADP
admet-1476	246	70	fe	fe	NOUN
admet-1476	246	71	and	and	CCONJ
admet-1476	246	72	the	the	DET
admet-1476	246	73	limiting	limit	VERB
admet-1476	246	74	steps	step	NOUN
admet-1476	246	75	in	in	ADP
admet-1476	246	76	the	the	DET
admet-1476	246	77	oral	oral	ADJ
admet-1476	246	78	absorption	absorption	NOUN
admet-1476	246	79	of	of	ADP
admet-1476	246	80	a	a	DET
admet-1476	246	81	new	new	ADJ
admet-1476	246	82	drug	drug	NOUN
admet-1476	246	83	candidate	candidate	NOUN
admet-1476	246	84	.	.	PUNCT
admet-1476	247	1	also	also	ADV
admet-1476	247	2	,	,	PUNCT
admet-1476	247	3	an	an	DET
admet-1476	247	4	increase	increase	NOUN
admet-1476	247	5	in	in	ADP
admet-1476	247	6	drug	drug	NOUN
admet-1476	247	7	solubility	solubility	NOUN
admet-1476	247	8	in	in	ADP
admet-1476	247	9	fessif	fessif	NOUN
admet-1476	247	10	medium	medium	NOUN
admet-1476	247	11	may	may	AUX
admet-1476	247	12	not	not	PART
admet-1476	247	13	always	always	ADV
admet-1476	247	14	results	result	VERB
admet-1476	247	15	in	in	ADP
admet-1476	247	16	an	an	DET
admet-1476	247	17	increase	increase	NOUN
admet-1476	247	18	in	in	ADP
admet-1476	247	19	oral	oral	ADJ
admet-1476	247	20	absorption	absorption	NOUN
admet-1476	247	21	.	.	PUNCT
admet-1476	248	1	using	use	VERB
admet-1476	248	2	40	40	NUM
admet-1476	248	3	compounds	compound	NOUN
admet-1476	248	4	,	,	PUNCT
admet-1476	248	5	kawai	kawai	PROPN
admet-1476	248	6	et	et	PROPN
admet-1476	248	7	al	al	PROPN
admet-1476	248	8	.	.	PUNCT
admet-1476	249	1	[	[	X
admet-1476	249	2	24	24	NUM
admet-1476	249	3	]	]	PUNCT
admet-1476	249	4	,	,	PUNCT
admet-1476	249	5	demonstrated	demonstrate	VERB
admet-1476	249	6	that	that	SCONJ
admet-1476	249	7	the	the	DET
admet-1476	249	8	risk	risk	NOUN
admet-1476	249	9	of	of	ADP
admet-1476	249	10	food	food	NOUN
admet-1476	249	11	effect	effect	NOUN
admet-1476	249	12	(	(	PUNCT
admet-1476	249	13	positive	positive	ADJ
admet-1476	249	14	,	,	PUNCT
admet-1476	249	15	negative	negative	ADJ
admet-1476	249	16	/	/	SYM
admet-1476	249	17	none	none	NOUN
admet-1476	249	18	)	)	PUNCT
admet-1476	249	19	can	can	AUX
admet-1476	249	20	be	be	AUX
admet-1476	249	21	assessed	assess	VERB
admet-1476	249	22	by	by	ADP
admet-1476	249	23	using	use	VERB
admet-1476	249	24	in	in	ADP
admet-1476	249	25	vitro	vitro	X
admet-1476	249	26	solubility	solubility	NOUN
admet-1476	249	27	data	datum	NOUN
admet-1476	249	28	and	and	CCONJ
admet-1476	249	29	in	in	ADP
admet-1476	249	30	vitro	vitro	X
admet-1476	249	31	membrane	membrane	NOUN
admet-1476	249	32	permeability	permeability	NOUN
admet-1476	249	33	data	datum	NOUN
admet-1476	249	34	.	.	PUNCT
admet-1476	250	1	the	the	DET
admet-1476	250	2	authors	author	NOUN
admet-1476	250	3	used	use	VERB
admet-1476	250	4	monolayer	monolayer	NOUN
admet-1476	250	5	of	of	ADP
admet-1476	250	6	madin	madin	PROPN
admet-1476	250	7	–	–	PUNCT
admet-1476	250	8	darby	darby	PROPN
admet-1476	250	9	canine	canine	PROPN
admet-1476	250	10	kidney	kidney	PROPN
admet-1476	250	11	(	(	PUNCT
admet-1476	250	12	mdck	mdck	PROPN
admet-1476	250	13	)	)	PUNCT
admet-1476	250	14	ii	ii	PROPN
admet-1476	250	15	cells	cell	NOUN
admet-1476	250	16	for	for	ADP
admet-1476	250	17	the	the	DET
admet-1476	250	18	membrane	membrane	NOUN
admet-1476	250	19	permeability	permeability	NOUN
admet-1476	250	20	study	study	NOUN
admet-1476	250	21	.	.	PUNCT
admet-1476	251	1	the	the	DET
admet-1476	251	2	authors	author	NOUN
admet-1476	251	3	successfully	successfully	ADV
admet-1476	251	4	conducted	conduct	VERB
admet-1476	251	5	the	the	DET
admet-1476	251	6	risk	risk	NOUN
admet-1476	251	7	assessment	assessment	NOUN
admet-1476	251	8	of	of	ADP
admet-1476	251	9	food	food	NOUN
admet-1476	251	10	effect	effect	NOUN
admet-1476	251	11	based	base	VERB
admet-1476	251	12	on	on	ADP
admet-1476	251	13	the	the	DET
admet-1476	251	14	physicochemical	physicochemical	ADJ
admet-1476	251	15	properties	property	NOUN
admet-1476	251	16	of	of	ADP
admet-1476	251	17	the	the	DET
admet-1476	251	18	compounds	compound	NOUN
admet-1476	251	19	.	.	PUNCT
admet-1476	252	1	in	in	ADP
admet-1476	252	2	the	the	DET
admet-1476	252	3	present	present	ADJ
admet-1476	252	4	research	research	NOUN
admet-1476	252	5	,	,	PUNCT
admet-1476	252	6	we	we	PRON
admet-1476	252	7	evaluated	evaluate	VERB
admet-1476	252	8	the	the	DET
admet-1476	252	9	diffusion	diffusion	NOUN
admet-1476	252	10	flux	flux	NOUN
admet-1476	252	11	(	(	PUNCT
admet-1476	252	12	membrane	membrane	NOUN
admet-1476	252	13	transport	transport	NOUN
admet-1476	252	14	rate	rate	NOUN
admet-1476	252	15	)	)	PUNCT
admet-1476	252	16	across	across	ADP
admet-1476	252	17	artificial	artificial	ADJ
admet-1476	252	18	,	,	PUNCT
admet-1476	252	19	lipid	lipid	NOUN
admet-1476	252	20	coated	coat	VERB
admet-1476	252	21	membrane	membrane	NOUN
admet-1476	252	22	,	,	PUNCT
admet-1476	252	23	using	use	VERB
admet-1476	252	24	side	side	NOUN
admet-1476	252	25	-	-	PUNCT
admet-1476	252	26	by	by	ADP
admet-1476	252	27	-	-	PUNCT
admet-1476	252	28	side	side	NOUN
admet-1476	252	29	donor	donor	NOUN
admet-1476	252	30	and	and	CCONJ
admet-1476	252	31	receiver	receiver	ADJ
admet-1476	252	32	chambers	chamber	NOUN
admet-1476	252	33	.	.	PUNCT
admet-1476	253	1	the	the	DET
admet-1476	253	2	mdck	mdck	PROPN
admet-1476	253	3	ii	ii	PROPN
admet-1476	253	4	monolayer	monolayer	NOUN
admet-1476	253	5	is	be	AUX
admet-1476	253	6	expensive	expensive	ADJ
admet-1476	253	7	,	,	PUNCT
admet-1476	253	8	and	and	CCONJ
admet-1476	253	9	it	it	PRON
admet-1476	253	10	is	be	AUX
admet-1476	253	11	time	time	NOUN
admet-1476	253	12	consuming	consume	VERB
admet-1476	253	13	to	to	PART
admet-1476	253	14	grow	grow	VERB
admet-1476	253	15	the	the	DET
admet-1476	253	16	layer	layer	NOUN
admet-1476	253	17	as	as	SCONJ
admet-1476	253	18	compared	compare	VERB
admet-1476	253	19	to	to	ADP
admet-1476	253	20	the	the	DET
admet-1476	253	21	artificial	artificial	ADJ
admet-1476	253	22	lipid	lipid	NOUN
admet-1476	253	23	coated	coat	VERB
admet-1476	253	24	membrane	membrane	NOUN
admet-1476	253	25	,	,	PUNCT
admet-1476	253	26	for	for	ADP
admet-1476	253	27	the	the	DET
admet-1476	253	28	permeability	permeability	NOUN
admet-1476	253	29	study	study	NOUN
admet-1476	253	30	.	.	PUNCT
admet-1476	254	1	secondly	secondly	ADV
admet-1476	254	2	,	,	PUNCT
admet-1476	254	3	one	one	PRON
admet-1476	254	4	can	can	AUX
admet-1476	254	5	determine	determine	VERB
admet-1476	254	6	the	the	DET
admet-1476	254	7	kinetic	kinetic	ADJ
admet-1476	254	8	solubility	solubility	NOUN
admet-1476	254	9	(	(	PUNCT
admet-1476	254	10	dissolution	dissolution	NOUN
admet-1476	254	11	)	)	PUNCT
admet-1476	254	12	and	and	CCONJ
admet-1476	254	13	diffusion	diffusion	NOUN
admet-1476	254	14	flux	flux	NOUN
admet-1476	254	15	in	in	ADP
admet-1476	254	16	single	single	ADJ
admet-1476	254	17	setup	setup	NOUN
admet-1476	254	18	using	use	VERB
admet-1476	254	19	side	side	NOUN
admet-1476	254	20	-	-	PUNCT
admet-1476	254	21	by	by	ADP
admet-1476	254	22	-	-	PUNCT
admet-1476	254	23	side	side	NOUN
admet-1476	254	24	donor	donor	NOUN
admet-1476	254	25	and	and	CCONJ
admet-1476	254	26	receiver	receiver	ADJ
admet-1476	254	27	chambers	chamber	NOUN
admet-1476	254	28	.	.	PUNCT
admet-1476	255	1	overall	overall	ADV
admet-1476	255	2	,	,	PUNCT
admet-1476	255	3	the	the	DET
admet-1476	255	4	dissolution	dissolution	NOUN
admet-1476	255	5	/	/	SYM
admet-1476	255	6	flux	flux	NOUN
admet-1476	255	7	set	set	NOUN
admet-1476	255	8	-	-	PUNCT
admet-1476	255	9	up	up	NOUN
admet-1476	255	10	appears	appear	VERB
admet-1476	255	11	to	to	PART
admet-1476	255	12	be	be	AUX
admet-1476	255	13	a	a	DET
admet-1476	255	14	admet	admet	NOUN
admet-1476	255	15	&	&	CCONJ
admet-1476	255	16	dmpk	dmpk	PROPN
admet-1476	255	17	10(4	10(4	NUM
admet-1476	255	18	)	)	PUNCT
admet-1476	255	19	(	(	PUNCT
admet-1476	255	20	2022	2022	NUM
admet-1476	255	21	)	)	PUNCT
admet-1476	256	1	299	299	NUM
admet-1476	256	2	-	-	SYM
admet-1476	256	3	314	314	NUM
admet-1476	256	4	material	material	NOUN
admet-1476	256	5	sparing	sparing	NOUN
admet-1476	256	6	µflux	µflux	NOUN
admet-1476	256	7	methodology	methodology	NOUN
admet-1476	256	8	doi	doi	NOUN
admet-1476	256	9	:	:	PUNCT
admet-1476	256	10	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	NOUN
admet-1476	256	11	311	311	NUM
admet-1476	256	12	useful	useful	ADJ
admet-1476	256	13	and	and	CCONJ
admet-1476	256	14	better	well	ADJ
admet-1476	256	15	tool	tool	NOUN
admet-1476	256	16	to	to	PART
admet-1476	256	17	predict	predict	VERB
admet-1476	256	18	the	the	DET
admet-1476	256	19	food	food	NOUN
admet-1476	256	20	effect	effect	NOUN
admet-1476	256	21	than	than	ADP
admet-1476	256	22	the	the	DET
admet-1476	256	23	solubility	solubility	NOUN
admet-1476	256	24	ratio	ratio	NOUN
admet-1476	256	25	.	.	PUNCT
admet-1476	257	1	as	as	ADP
admet-1476	257	2	no	no	DET
admet-1476	257	3	in	in	ADP
admet-1476	257	4	vitro	vitro	X
admet-1476	257	5	technique	technique	NOUN
admet-1476	257	6	can	can	AUX
admet-1476	257	7	predict	predict	VERB
admet-1476	257	8	the	the	DET
admet-1476	257	9	intestinal	intestinal	ADJ
admet-1476	257	10	drug	drug	NOUN
admet-1476	257	11	metabolism	metabolism	NOUN
admet-1476	257	12	(	(	PUNCT
admet-1476	257	13	if	if	SCONJ
admet-1476	257	14	any	any	PRON
admet-1476	257	15	)	)	PUNCT
admet-1476	257	16	,	,	PUNCT
admet-1476	257	17	or	or	CCONJ
admet-1476	257	18	the	the	DET
admet-1476	257	19	impact	impact	NOUN
admet-1476	257	20	of	of	ADP
admet-1476	257	21	the	the	DET
admet-1476	257	22	transporters	transporter	NOUN
admet-1476	257	23	involved	involve	VERB
admet-1476	257	24	in	in	ADP
admet-1476	257	25	the	the	DET
admet-1476	257	26	drug	drug	NOUN
admet-1476	257	27	absorption	absorption	NOUN
admet-1476	257	28	,	,	PUNCT
admet-1476	257	29	the	the	DET
admet-1476	257	30	dissolution	dissolution	NOUN
admet-1476	257	31	/	/	SYM
admet-1476	257	32	flux	flux	NOUN
admet-1476	257	33	set	set	NOUN
admet-1476	257	34	-	-	PUNCT
admet-1476	257	35	up	up	NOUN
admet-1476	257	36	could	could	AUX
admet-1476	257	37	not	not	PART
admet-1476	257	38	predict	predict	VERB
admet-1476	257	39	the	the	DET
admet-1476	257	40	negative	negative	ADJ
admet-1476	257	41	food	food	NOUN
admet-1476	257	42	effect	effect	NOUN
admet-1476	257	43	successfully	successfully	ADV
admet-1476	257	44	.	.	PUNCT
admet-1476	258	1	also	also	ADV
admet-1476	258	2	,	,	PUNCT
admet-1476	258	3	it	it	PRON
admet-1476	258	4	is	be	AUX
admet-1476	258	5	imperative	imperative	ADJ
admet-1476	258	6	to	to	PART
admet-1476	258	7	note	note	VERB
admet-1476	258	8	that	that	SCONJ
admet-1476	258	9	we	we	PRON
admet-1476	258	10	compared	compare	VERB
admet-1476	258	11	the	the	DET
admet-1476	258	12	published	publish	VERB
admet-1476	258	13	clinical	clinical	ADJ
admet-1476	258	14	data	datum	NOUN
admet-1476	258	15	that	that	PRON
admet-1476	258	16	was	be	AUX
admet-1476	258	17	generated	generate	VERB
admet-1476	258	18	using	use	VERB
admet-1476	258	19	the	the	DET
admet-1476	258	20	formulated	formulate	VERB
admet-1476	258	21	drug	drug	NOUN
admet-1476	258	22	product	product	NOUN
admet-1476	258	23	with	with	ADP
admet-1476	258	24	that	that	PRON
admet-1476	258	25	of	of	ADP
admet-1476	258	26	in	in	ADP
admet-1476	258	27	vitro	vitro	X
admet-1476	258	28	data	datum	NOUN
admet-1476	258	29	generated	generate	VERB
admet-1476	258	30	using	use	VERB
admet-1476	258	31	unformulated	unformulate	VERB
admet-1476	258	32	dug	dig	VERB
admet-1476	258	33	substance	substance	NOUN
admet-1476	258	34	.	.	PUNCT
admet-1476	259	1	this	this	PRON
admet-1476	259	2	might	might	AUX
admet-1476	259	3	be	be	AUX
admet-1476	259	4	the	the	DET
admet-1476	259	5	reason	reason	NOUN
admet-1476	259	6	for	for	ADP
admet-1476	259	7	the	the	DET
admet-1476	259	8	quantitative	quantitative	ADJ
admet-1476	259	9	differences	difference	NOUN
admet-1476	259	10	observed	observe	VERB
admet-1476	259	11	between	between	ADP
admet-1476	259	12	the	the	DET
admet-1476	259	13	in	in	X
admet-1476	259	14	vitro	vitro	X
admet-1476	259	15	data	datum	NOUN
admet-1476	259	16	and	and	CCONJ
admet-1476	259	17	the	the	DET
admet-1476	259	18	published	publish	VERB
admet-1476	259	19	clinical	clinical	ADJ
admet-1476	259	20	data	datum	NOUN
admet-1476	259	21	.	.	PUNCT
admet-1476	260	1	but	but	CCONJ
admet-1476	260	2	the	the	DET
admet-1476	260	3	combination	combination	NOUN
admet-1476	260	4	of	of	ADP
admet-1476	260	5	dissolution	dissolution	NOUN
admet-1476	260	6	/	/	SYM
admet-1476	260	7	flux	flux	NOUN
admet-1476	260	8	(	(	PUNCT
admet-1476	260	9	diffusion	diffusion	NOUN
admet-1476	260	10	flux	flux	PROPN
admet-1476	260	11	measurement	measurement	PROPN
admet-1476	260	12	across	across	ADP
admet-1476	260	13	artificial	artificial	ADJ
admet-1476	260	14	lipid	lipid	NOUN
admet-1476	260	15	barrier	barrier	NOUN
admet-1476	260	16	)	)	PUNCT
admet-1476	260	17	may	may	AUX
admet-1476	260	18	provide	provide	VERB
admet-1476	260	19	very	very	ADV
admet-1476	260	20	good	good	ADJ
admet-1476	260	21	qualitative	qualitative	ADJ
admet-1476	260	22	insight	insight	NOUN
admet-1476	260	23	about	about	ADP
admet-1476	260	24	the	the	DET
admet-1476	260	25	food	food	NOUN
admet-1476	260	26	effect	effect	NOUN
admet-1476	260	27	of	of	ADP
admet-1476	260	28	permeability	permeability	NOUN
admet-1476	260	29	limited	limit	VERB
admet-1476	260	30	,	,	PUNCT
admet-1476	260	31	dissolution	dissolution	NOUN
admet-1476	260	32	rate	rate	NOUN
admet-1476	260	33	limited	limit	VERB
admet-1476	260	34	and	and	CCONJ
admet-1476	260	35	solubility	solubility	NOUN
admet-1476	260	36	limited	limit	VERB
admet-1476	260	37	compounds	compound	NOUN
admet-1476	260	38	.	.	PUNCT
admet-1476	261	1	conclusion	conclusion	NOUN
admet-1476	261	2	in	in	ADP
admet-1476	261	3	the	the	DET
admet-1476	261	4	present	present	ADJ
admet-1476	261	5	research	research	NOUN
admet-1476	261	6	,	,	PUNCT
admet-1476	261	7	using	use	VERB
admet-1476	261	8	11	11	NUM
admet-1476	261	9	model	model	NOUN
admet-1476	261	10	compounds	compound	NOUN
admet-1476	261	11	with	with	ADP
admet-1476	261	12	diverse	diverse	ADJ
admet-1476	261	13	physicochemical	physicochemical	ADJ
admet-1476	261	14	and	and	CCONJ
admet-1476	261	15	pharmacokinetic	pharmacokinetic	ADJ
admet-1476	261	16	properties	property	NOUN
admet-1476	261	17	,	,	PUNCT
admet-1476	261	18	we	we	PRON
admet-1476	261	19	demonstrate	demonstrate	VERB
admet-1476	261	20	that	that	SCONJ
admet-1476	261	21	a	a	DET
admet-1476	261	22	combination	combination	NOUN
admet-1476	261	23	of	of	ADP
admet-1476	261	24	dissolution	dissolution	NOUN
admet-1476	261	25	and	and	CCONJ
admet-1476	261	26	permeation	permeation	NOUN
admet-1476	261	27	(	(	PUNCT
admet-1476	261	28	diffusion	diffusion	NOUN
admet-1476	261	29	flux	flux	PROPN
admet-1476	261	30	measurement	measurement	PROPN
admet-1476	261	31	)	)	PUNCT
admet-1476	261	32	has	have	VERB
admet-1476	261	33	better	well	ADJ
admet-1476	261	34	food	food	NOUN
admet-1476	261	35	effect	effect	NOUN
admet-1476	261	36	predictive	predictive	ADJ
admet-1476	261	37	capability	capability	NOUN
admet-1476	261	38	than	than	ADP
admet-1476	261	39	the	the	DET
admet-1476	261	40	solubility	solubility	NOUN
admet-1476	261	41	/	/	SYM
admet-1476	261	42	dissolution	dissolution	NOUN
admet-1476	261	43	alone	alone	ADV
admet-1476	261	44	.	.	PUNCT
admet-1476	262	1	the	the	DET
admet-1476	262	2	flux	flux	NOUN
admet-1476	262	3	-	-	PUNCT
admet-1476	262	4	based	base	VERB
admet-1476	262	5	method	method	NOUN
admet-1476	262	6	with	with	ADP
admet-1476	262	7	lipid	lipid	NOUN
admet-1476	262	8	-	-	PUNCT
admet-1476	262	9	coated	coat	VERB
admet-1476	262	10	artificial	artificial	ADJ
admet-1476	262	11	membrane	membrane	NOUN
admet-1476	262	12	was	be	AUX
admet-1476	262	13	found	find	VERB
admet-1476	262	14	to	to	PART
admet-1476	262	15	be	be	AUX
admet-1476	262	16	more	more	ADV
admet-1476	262	17	reliable	reliable	ADJ
admet-1476	262	18	than	than	ADP
admet-1476	262	19	the	the	DET
admet-1476	262	20	solubility	solubility	NOUN
admet-1476	262	21	/	/	SYM
admet-1476	262	22	dissolution	dissolution	NOUN
admet-1476	262	23	alone	alone	ADV
admet-1476	262	24	in	in	ADP
admet-1476	262	25	predicting	predict	VERB
admet-1476	262	26	the	the	DET
admet-1476	262	27	food	food	NOUN
admet-1476	262	28	effect	effect	NOUN
admet-1476	262	29	in	in	ADP
admet-1476	262	30	the	the	DET
admet-1476	262	31	cases	case	NOUN
admet-1476	262	32	where	where	SCONJ
admet-1476	262	33	the	the	DET
admet-1476	262	34	drug	drug	NOUN
admet-1476	262	35	absorption	absorption	NOUN
admet-1476	262	36	was	be	AUX
admet-1476	262	37	driven	drive	VERB
admet-1476	262	38	by	by	ADP
admet-1476	262	39	passive	passive	ADJ
admet-1476	262	40	transcellular	transcellular	NOUN
admet-1476	262	41	diffusion	diffusion	NOUN
admet-1476	262	42	.	.	PUNCT
admet-1476	263	1	the	the	DET
admet-1476	263	2	combination	combination	NOUN
admet-1476	263	3	of	of	ADP
admet-1476	263	4	dissolution	dissolution	NOUN
admet-1476	263	5	and	and	CCONJ
admet-1476	263	6	diffusion	diffusion	NOUN
admet-1476	263	7	flux	flux	NOUN
admet-1476	263	8	may	may	AUX
admet-1476	263	9	not	not	PART
admet-1476	263	10	reliably	reliably	ADV
admet-1476	263	11	predict	predict	VERB
admet-1476	263	12	the	the	DET
admet-1476	263	13	food	food	NOUN
admet-1476	263	14	effect	effect	NOUN
admet-1476	263	15	in	in	ADP
admet-1476	263	16	case	case	NOUN
admet-1476	263	17	of	of	ADP
admet-1476	263	18	drugs	drug	NOUN
admet-1476	263	19	undergoing	undergo	VERB
admet-1476	263	20	intestinal	intestinal	ADJ
admet-1476	263	21	metabolism	metabolism	NOUN
admet-1476	263	22	or	or	CCONJ
admet-1476	263	23	where	where	SCONJ
admet-1476	263	24	transporters	transporter	NOUN
admet-1476	263	25	are	be	AUX
admet-1476	263	26	involved	involve	VERB
admet-1476	263	27	in	in	ADP
admet-1476	263	28	the	the	DET
admet-1476	263	29	drug	drug	NOUN
admet-1476	263	30	absorption	absorption	NOUN
admet-1476	263	31	.	.	PUNCT
admet-1476	264	1	but	but	CCONJ
admet-1476	264	2	the	the	DET
admet-1476	264	3	technique	technique	NOUN
admet-1476	264	4	provides	provide	VERB
admet-1476	264	5	good	good	ADJ
admet-1476	264	6	qualitative	qualitative	ADJ
admet-1476	264	7	information	information	NOUN
admet-1476	264	8	about	about	ADP
admet-1476	264	9	the	the	DET
admet-1476	264	10	food	food	NOUN
admet-1476	264	11	effect	effect	NOUN
admet-1476	264	12	at	at	ADP
admet-1476	264	13	very	very	ADV
admet-1476	264	14	early	early	ADJ
admet-1476	264	15	stages	stage	NOUN
admet-1476	264	16	of	of	ADP
admet-1476	264	17	drug	drug	NOUN
admet-1476	264	18	development	development	NOUN
admet-1476	264	19	that	that	PRON
admet-1476	264	20	may	may	AUX
admet-1476	264	21	help	help	VERB
admet-1476	264	22	in	in	ADP
admet-1476	264	23	designing	design	VERB
admet-1476	264	24	a	a	DET
admet-1476	264	25	clinical	clinical	ADJ
admet-1476	264	26	plan	plan	NOUN
admet-1476	264	27	by	by	ADP
admet-1476	264	28	adjusting	adjust	VERB
admet-1476	264	29	the	the	DET
admet-1476	264	30	drug	drug	NOUN
admet-1476	264	31	dose	dose	VERB
admet-1476	264	32	in	in	ADP
admet-1476	264	33	fed	fed	PROPN
admet-1476	264	34	state	state	NOUN
admet-1476	264	35	.	.	PUNCT
admet-1476	265	1	conflict	conflict	NOUN
admet-1476	265	2	of	of	ADP
admet-1476	265	3	interest	interest	NOUN
admet-1476	265	4	:	:	PUNCT
admet-1476	265	5	all	all	DET
admet-1476	265	6	authors	author	NOUN
admet-1476	265	7	declare	declare	VERB
admet-1476	265	8	that	that	SCONJ
admet-1476	265	9	they	they	PRON
admet-1476	265	10	have	have	VERB
admet-1476	265	11	no	no	DET
admet-1476	265	12	conflicts	conflict	NOUN
admet-1476	265	13	of	of	ADP
admet-1476	265	14	interest	interest	NOUN
admet-1476	265	15	.	.	PUNCT
admet-1476	266	1	oksana	oksana	PROPN
admet-1476	266	2	tsinman	tsinman	PROPN
admet-1476	266	3	is	be	AUX
admet-1476	266	4	an	an	DET
admet-1476	266	5	employee	employee	NOUN
admet-1476	266	6	of	of	ADP
admet-1476	266	7	pion	pion	PROPN
admet-1476	266	8	inc	inc	PROPN
admet-1476	266	9	.	.	PROPN
admet-1476	266	10	,	,	PUNCT
admet-1476	266	11	maker	maker	NOUN
admet-1476	266	12	of	of	ADP
admet-1476	266	13	the	the	DET
admet-1476	266	14	instrument	instrument	NOUN
admet-1476	266	15	used	use	VERB
admet-1476	266	16	for	for	ADP
admet-1476	266	17	the	the	DET
admet-1476	266	18	current	current	ADJ
admet-1476	266	19	research	research	NOUN
admet-1476	266	20	.	.	PUNCT
admet-1476	267	1	authors	author	NOUN
admet-1476	267	2	or	or	CCONJ
admet-1476	267	3	their	their	PRON
admet-1476	267	4	institutions	institution	NOUN
admet-1476	267	5	have	have	AUX
admet-1476	267	6	never	never	ADV
admet-1476	267	7	received	receive	VERB
admet-1476	267	8	payment	payment	NOUN
admet-1476	267	9	or	or	CCONJ
admet-1476	267	10	services	service	NOUN
admet-1476	267	11	from	from	ADP
admet-1476	267	12	a	a	DET
admet-1476	267	13	third	third	ADJ
admet-1476	267	14	party	party	NOUN
admet-1476	267	15	for	for	ADP
admet-1476	267	16	any	any	DET
admet-1476	267	17	aspect	aspect	NOUN
admet-1476	267	18	of	of	ADP
admet-1476	267	19	the	the	DET
admet-1476	267	20	submitted	submit	VERB
admet-1476	267	21	work	work	NOUN
admet-1476	267	22	.	.	PUNCT
admet-1476	268	1	references	reference	NOUN
admet-1476	268	2	[	[	X
admet-1476	268	3	1	1	X
admet-1476	268	4	]	]	PUNCT
admet-1476	268	5	d.	d.	PROPN
admet-1476	268	6	sahoo	sahoo	PROPN
admet-1476	268	7	,	,	PUNCT
admet-1476	268	8	r.	r.	PROPN
admet-1476	268	9	bandaru	bandaru	PROPN
admet-1476	268	10	,	,	PUNCT
admet-1476	268	11	s.	s.	PROPN
admet-1476	268	12	k.	k.	PROPN
admet-1476	268	13	samal	samal	PROPN
admet-1476	268	14	,	,	PUNCT
admet-1476	268	15	r.	r.	PROPN
admet-1476	268	16	naik	naik	PROPN
admet-1476	268	17	,	,	PUNCT
admet-1476	268	18	p.	p.	PROPN
admet-1476	268	19	kumar	kumar	PROPN
admet-1476	268	20	,	,	PUNCT
admet-1476	268	21	p.	p.	PROPN
admet-1476	268	22	kesharwani	kesharwani	PROPN
admet-1476	268	23	,	,	PUNCT
admet-1476	268	24	r.	r.	PROPN
admet-1476	268	25	dandela	dandela	PROPN
admet-1476	268	26	,	,	PUNCT
admet-1476	268	27	theory	theory	NOUN
admet-1476	268	28	and	and	CCONJ
admet-1476	268	29	applications	application	NOUN
admet-1476	268	30	of	of	ADP
admet-1476	268	31	nonparenteral	nonparenteral	ADJ
admet-1476	268	32	nanomedicines	nanomedicine	NOUN
admet-1476	268	33	,	,	PUNCT
admet-1476	268	34	academic	academic	ADJ
admet-1476	268	35	press	press	NOUN
admet-1476	268	36	,	,	PUNCT
admet-1476	268	37	london	london	PROPN
admet-1476	268	38	,	,	PUNCT
admet-1476	268	39	united	united	ADJ
admet-1476	268	40	kingdom	kingdom	PROPN
admet-1476	268	41	,	,	PUNCT
admet-1476	268	42	2021	2021	NUM
admet-1476	268	43	,	,	PUNCT
admet-1476	268	44	181	181	NUM
admet-1476	268	45	-	-	SYM
admet-1476	268	46	207	207	NUM
admet-1476	268	47	.	.	PUNCT
admet-1476	269	1	https://doi.org/10.1016/b978-0-12-820466-5.00009-0	https://doi.org/10.1016/b978-0-12-820466-5.00009-0	NOUN
admet-1476	269	2	.	.	PUNCT
admet-1476	270	1	[	[	X
admet-1476	270	2	2	2	NUM
admet-1476	270	3	]	]	PUNCT
admet-1476	270	4	n.	n.	PROPN
admet-1476	270	5	k.	k.	PROPN
admet-1476	270	6	thakral	thakral	PROPN
admet-1476	270	7	,	,	PUNCT
admet-1476	270	8	e.	e.	PROPN
admet-1476	270	9	meister	meister	PROPN
admet-1476	270	10	,	,	PUNCT
admet-1476	270	11	c.	c.	PROPN
admet-1476	270	12	jankovsky	jankovsky	PROPN
admet-1476	270	13	,	,	PUNCT
admet-1476	270	14	l.	l.	PROPN
admet-1476	270	15	li	li	PROPN
admet-1476	270	16	,	,	PUNCT
admet-1476	270	17	r.	r.	PROPN
admet-1476	270	18	schwabe	schwabe	PROPN
admet-1476	270	19	,	,	PUNCT
admet-1476	270	20	l.	l.	PROPN
admet-1476	270	21	luo	luo	PROPN
admet-1476	270	22	,	,	PUNCT
admet-1476	270	23	s.	s.	PROPN
admet-1476	270	24	chen	chen	PROPN
admet-1476	270	25	.	.	PUNCT
admet-1476	271	1	prediction	prediction	NOUN
admet-1476	271	2	of	of	ADP
admet-1476	271	3	in	in	ADP
admet-1476	271	4	vivo	vivo	ADJ
admet-1476	271	5	supersaturation	supersaturation	NOUN
admet-1476	271	6	and	and	CCONJ
admet-1476	271	7	precipitation	precipitation	NOUN
admet-1476	271	8	of	of	ADP
admet-1476	271	9	poorly	poorly	ADV
admet-1476	271	10	water	water	NOUN
admet-1476	271	11	-	-	PUNCT
admet-1476	271	12	soluble	soluble	ADJ
admet-1476	271	13	drugs	drug	NOUN
admet-1476	271	14	:	:	PUNCT
admet-1476	271	15	achievements	achievement	NOUN
admet-1476	271	16	and	and	CCONJ
admet-1476	271	17	aspirations	aspiration	NOUN
admet-1476	271	18	.	.	PUNCT
admet-1476	272	1	international	international	ADJ
admet-1476	272	2	journal	journal	PROPN
admet-1476	272	3	of	of	ADP
admet-1476	272	4	pharmaceutics	pharmaceutic	NOUN
admet-1476	272	5	600	600	NUM
admet-1476	272	6	(	(	PUNCT
admet-1476	272	7	2021	2021	NUM
admet-1476	272	8	)	)	PUNCT
admet-1476	272	9	.	.	PUNCT
admet-1476	273	1	https://doi.org/10.1016/j.ijpharm.2021.120505	https://doi.org/10.1016/j.ijpharm.2021.120505	NOUN
admet-1476	273	2	.	.	PUNCT
admet-1476	274	1	[	[	X
admet-1476	274	2	3	3	X
admet-1476	274	3	]	]	PUNCT
admet-1476	274	4	s.	s.	PROPN
admet-1476	274	5	sharma	sharma	PROPN
admet-1476	274	6	,	,	PUNCT
admet-1476	274	7	b.	b.	PROPN
admet-1476	274	8	prasad	prasad	PROPN
admet-1476	274	9	.	.	PUNCT
admet-1476	275	1	meta	meta	VERB
admet-1476	275	2	-	-	PUNCT
admet-1476	275	3	analysis	analysis	NOUN
admet-1476	275	4	of	of	ADP
admet-1476	275	5	food	food	NOUN
admet-1476	275	6	effect	effect	NOUN
admet-1476	275	7	on	on	ADP
admet-1476	275	8	oral	oral	ADJ
admet-1476	275	9	absorption	absorption	NOUN
admet-1476	275	10	of	of	ADP
admet-1476	275	11	efflux	efflux	NOUN
admet-1476	275	12	transporter	transporter	NOUN
admet-1476	275	13	substrate	substrate	NOUN
admet-1476	275	14	drugs	drug	NOUN
admet-1476	275	15	:	:	PUNCT
admet-1476	275	16	does	do	AUX
admet-1476	275	17	delayed	delay	VERB
admet-1476	275	18	gastric	gastric	ADJ
admet-1476	275	19	emptying	empty	VERB
admet-1476	275	20	influence	influence	NOUN
admet-1476	275	21	drug	drug	NOUN
admet-1476	275	22	transport	transport	NOUN
admet-1476	275	23	kinetics	kinetic	NOUN
admet-1476	275	24	?	?	PUNCT
admet-1476	275	25	.	.	PUNCT
admet-1476	276	1	pharmaceutics	pharmaceutic	NOUN
admet-1476	276	2	13	13	NUM
admet-1476	276	3	(	(	PUNCT
admet-1476	276	4	2021	2021	NUM
admet-1476	276	5	)	)	PUNCT
admet-1476	276	6	1	1	NUM
admet-1476	276	7	-	-	SYM
admet-1476	276	8	2	2	NUM
admet-1476	276	9	.	.	PUNCT
admet-1476	276	10	https://doi.org/10.3390/pharmaceutics13071035	https://doi.org/10.3390/pharmaceutics13071035	NOUN
admet-1476	276	11	.	.	PUNCT
admet-1476	277	1	[	[	X
admet-1476	277	2	4	4	NUM
admet-1476	277	3	]	]	X
admet-1476	277	4	c.	c.	PROPN
admet-1476	277	5	m.	m.	PROPN
admet-1476	277	6	madsen	madsen	PROPN
admet-1476	277	7	,	,	PUNCT
admet-1476	277	8	b.	b.	PROPN
admet-1476	277	9	boyd	boyd	PROPN
admet-1476	277	10	,	,	PUNCT
admet-1476	277	11	t.	t.	PROPN
admet-1476	277	12	rades	rades	PROPN
admet-1476	277	13	,	,	PUNCT
admet-1476	277	14	a.	a.	NOUN
admet-1476	277	15	müllertz	müllertz	NOUN
admet-1476	277	16	.	.	PUNCT
admet-1476	278	1	supersaturation	supersaturation	NOUN
admet-1476	278	2	of	of	ADP
admet-1476	278	3	zafirlukast	zafirlukast	NOUN
admet-1476	278	4	in	in	ADP
admet-1476	278	5	fasted	fast	VERB
admet-1476	278	6	and	and	CCONJ
admet-1476	278	7	fed	feed	VERB
admet-1476	278	8	state	state	NOUN
admet-1476	278	9	intestinal	intestinal	ADJ
admet-1476	278	10	media	medium	NOUN
admet-1476	278	11	with	with	ADP
admet-1476	278	12	and	and	CCONJ
admet-1476	278	13	without	without	ADP
admet-1476	278	14	precipitation	precipitation	NOUN
admet-1476	278	15	inhibitors	inhibitor	NOUN
admet-1476	278	16	.	.	PUNCT
admet-1476	279	1	european	european	ADJ
admet-1476	279	2	journal	journal	PROPN
admet-1476	279	3	of	of	ADP
admet-1476	279	4	pharmaceutical	pharmaceutical	PROPN
admet-1476	279	5	sciences	science	NOUN
admet-1476	279	6	91	91	NUM
admet-1476	279	7	(	(	PUNCT
admet-1476	279	8	2016	2016	NUM
admet-1476	279	9	)	)	PUNCT
admet-1476	279	10	31	31	NUM
admet-1476	279	11	-	-	SYM
admet-1476	279	12	39	39	NUM
admet-1476	279	13	.	.	PUNCT
admet-1476	280	1	https://doi.org/10.1016/j.ejps.2016.05.026	https://doi.org/10.1016/j.ejps.2016.05.026	X
admet-1476	280	2	.	.	PUNCT
admet-1476	281	1	[	[	X
admet-1476	281	2	5	5	NUM
admet-1476	281	3	]	]	X
admet-1476	281	4	n.	n.	NOUN
admet-1476	281	5	mathias	mathias	PROPN
admet-1476	281	6	,	,	PUNCT
admet-1476	281	7	y.	y.	PROPN
admet-1476	281	8	xu	xu	PROPN
admet-1476	281	9	,	,	PUNCT
admet-1476	281	10	b.	b.	PROPN
admet-1476	281	11	vig	vig	PROPN
admet-1476	281	12	,	,	PUNCT
admet-1476	281	13	u.	u.	PROPN
admet-1476	281	14	kestur	kestur	PROPN
admet-1476	281	15	,	,	PUNCT
admet-1476	281	16	a.	a.	PROPN
admet-1476	281	17	saari	saari	PROPN
admet-1476	281	18	,	,	PUNCT
admet-1476	281	19	j.	j.	PROPN
admet-1476	281	20	criston	criston	PROPN
admet-1476	281	21	,	,	PUNCT
admet-1476	281	22	d.	d.	PROPN
admet-1476	281	23	desai	desai	PROPN
admet-1476	281	24	,	,	PUNCT
admet-1476	281	25	a.	a.	PROPN
admet-1476	281	26	vanarase	vanarase	PROPN
admet-1476	281	27	,	,	PUNCT
admet-1476	281	28	m.	m.	NOUN
admet-1476	281	29	hussain	hussain	PROPN
admet-1476	281	30	.	.	PUNCT
admet-1476	282	1	food	food	NOUN
admet-1476	282	2	effect	effect	NOUN
admet-1476	282	3	in	in	ADP
admet-1476	282	4	humans	human	NOUN
admet-1476	282	5	:	:	PUNCT
admet-1476	282	6	predicting	predict	VERB
admet-1476	282	7	the	the	DET
admet-1476	282	8	risk	risk	NOUN
admet-1476	282	9	through	through	ADP
admet-1476	282	10	in	in	ADP
admet-1476	282	11	vitro	vitro	X
admet-1476	282	12	dissolution	dissolution	NOUN
admet-1476	282	13	and	and	CCONJ
admet-1476	282	14	in	in	ADP
admet-1476	282	15	vivo	vivo	ADJ
admet-1476	282	16	pharmacokinetic	pharmacokinetic	ADJ
admet-1476	282	17	models	model	NOUN
admet-1476	282	18	.	.	PUNCT
admet-1476	283	1	the	the	DET
admet-1476	283	2	aaps	aaps	PROPN
admet-1476	283	3	journal	journal	PROPN
admet-1476	283	4	17	17	NUM
admet-1476	283	5	(	(	PUNCT
admet-1476	283	6	2015	2015	NUM
admet-1476	283	7	)	)	PUNCT
admet-1476	283	8	988	988	NUM
admet-1476	283	9	-	-	SYM
admet-1476	283	10	998	998	NUM
admet-1476	283	11	.	.	PUNCT
admet-1476	284	1	https://doi.org/10.1208/s12248-015-9759-z	https://doi.org/10.1208/s12248-015-9759-z	NOUN
admet-1476	284	2	.	.	PUNCT
admet-1476	285	1	[	[	X
admet-1476	285	2	6	6	NUM
admet-1476	285	3	]	]	X
admet-1476	285	4	gammaitoni	gammaitoni	NOUN
admet-1476	285	5	,	,	PUNCT
admet-1476	285	6	s.	s.	PROPN
admet-1476	285	7	smith	smith	PROPN
admet-1476	285	8	,	,	PUNCT
admet-1476	285	9	b.	b.	PROPN
admet-1476	285	10	boyd	boyd	PROPN
admet-1476	285	11	.	.	PUNCT
admet-1476	286	1	the	the	DET
admet-1476	286	2	lack	lack	NOUN
admet-1476	286	3	of	of	ADP
admet-1476	286	4	effect	effect	NOUN
admet-1476	286	5	of	of	ADP
admet-1476	286	6	food	food	NOUN
admet-1476	286	7	on	on	ADP
admet-1476	286	8	the	the	DET
admet-1476	286	9	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	286	10	of	of	ADP
admet-1476	286	11	zx008	zx008	NOUN
admet-1476	286	12	(	(	PUNCT
admet-1476	286	13	fenfluramine	fenfluramine	ADJ
admet-1476	286	14	oral	oral	ADJ
admet-1476	286	15	solution	solution	NOUN
admet-1476	286	16	):	):	PUNCT
admet-1476	286	17	results	result	NOUN
admet-1476	286	18	of	of	ADP
admet-1476	286	19	a	a	DET
admet-1476	286	20	single	single	ADJ
admet-1476	286	21	-	-	PUNCT
admet-1476	286	22	dose	dose	NOUN
admet-1476	286	23	,	,	PUNCT
admet-1476	286	24	two	two	NUM
admet-1476	286	25	-	-	PUNCT
admet-1476	286	26	period	period	NOUN
admet-1476	286	27	crossover	crossover	NOUN
admet-1476	286	28	study	study	NOUN
admet-1476	286	29	.	.	PUNCT
admet-1476	287	1	clinical	clinical	ADJ
admet-1476	287	2	therapeutics	therapeutic	NOUN
admet-1476	287	3	40	40	NUM
admet-1476	287	4	(	(	PUNCT
admet-1476	287	5	2018	2018	NUM
admet-1476	287	6	)	)	PUNCT
admet-1476	287	7	1338	1338	NUM
admet-1476	287	8	-	-	SYM
admet-1476	287	9	1346	1346	NUM
admet-1476	287	10	.	.	PUNCT
admet-1476	288	1	https://doi:10.1016	https://doi:10.1016	PROPN
admet-1476	288	2	/	/	SYM
admet-1476	288	3	j.clinthera.2018.05.013	j.clinthera.2018.05.013	PROPN
admet-1476	288	4	.	.	PROPN
admet-1476	289	1	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	PROPN
admet-1476	289	2	https://doi.org/10.1016/b978-0-12-820466-5.00009-0	https://doi.org/10.1016/b978-0-12-820466-5.00009-0	PROPN
admet-1476	289	3	https://doi.org/10.1016/j.ijpharm.2021.120505	https://doi.org/10.1016/j.ijpharm.2021.120505	PROPN
admet-1476	289	4	https://doi.org/10.1016/j.ijpharm.2021.120505	https://doi.org/10.1016/j.ijpharm.2021.120505	NOUN
admet-1476	289	5	https://doi.org/10.3390/pharmaceutics13071035	https://doi.org/10.3390/pharmaceutics13071035	NOUN
admet-1476	289	6	https://doi.org/10.1016/j.ejps.2016.05.026	https://doi.org/10.1016/j.ejps.2016.05.026	VERB
admet-1476	289	7	https://doi.org/10.1208/s12248-015-9759-z	https://doi.org/10.1208/s12248-015-9759-z	NOUN
admet-1476	289	8	about	about	ADP
admet-1476	289	9	:	:	PUNCT
admet-1476	290	1	blank	blank	ADJ
admet-1476	290	2	c.	c.	PROPN
admet-1476	290	3	jankovsky	jankovsky	PROPN
admet-1476	290	4	et	et	PROPN
admet-1476	290	5	al	al	PROPN
admet-1476	290	6	.	.	PROPN
admet-1476	290	7	admet	admet	PROPN
admet-1476	290	8	&	&	CCONJ
admet-1476	290	9	dmpk	dmpk	PROPN
admet-1476	290	10	10(4	10(4	NUM
admet-1476	290	11	)	)	PUNCT
admet-1476	290	12	(	(	PUNCT
admet-1476	290	13	2022	2022	NUM
admet-1476	290	14	)	)	PUNCT
admet-1476	290	15	299	299	NUM
admet-1476	290	16	-	-	SYM
admet-1476	290	17	314	314	NUM
admet-1476	290	18	312	312	NUM
admet-1476	290	19	[	[	X
admet-1476	290	20	7	7	NUM
admet-1476	290	21	]	]	X
admet-1476	290	22	xie	xie	PROPN
admet-1476	290	23	,	,	PUNCT
admet-1476	290	24	w.	w.	PROPN
admet-1476	290	25	huang	huang	PROPN
admet-1476	290	26	,	,	PUNCT
admet-1476	290	27	r.l.young	r.l.young	PROPN
admet-1476	290	28	,	,	PUNCT
admet-1476	290	29	k.l	k.l	PROPN
admet-1476	290	30	.	.	PROPN
admet-1476	290	31	jones	jones	PROPN
admet-1476	290	32	,	,	PUNCT
admet-1476	290	33	m.	m.	PROPN
admet-1476	290	34	horowitz	horowitz	PROPN
admet-1476	290	35	,	,	PUNCT
admet-1476	290	36	c.k	c.k	PROPN
admet-1476	290	37	.	.	PROPN
admet-1476	290	38	rayner	rayner	PROPN
admet-1476	290	39	,	,	PUNCT
admet-1476	290	40	t.	t.	PROPN
admet-1476	290	41	wu	wu	PROPN
admet-1476	290	42	.	.	PUNCT
admet-1476	291	1	role	role	NOUN
admet-1476	291	2	of	of	ADP
admet-1476	291	3	bile	bile	NOUN
admet-1476	291	4	acids	acid	NOUN
admet-1476	291	5	in	in	ADP
admet-1476	291	6	the	the	DET
admet-1476	291	7	regulation	regulation	NOUN
admet-1476	291	8	of	of	ADP
admet-1476	291	9	food	food	NOUN
admet-1476	291	10	intake	intake	NOUN
admet-1476	291	11	,	,	PUNCT
admet-1476	291	12	and	and	CCONJ
admet-1476	291	13	their	their	PRON
admet-1476	291	14	dysregulation	dysregulation	NOUN
admet-1476	291	15	in	in	ADP
admet-1476	291	16	metabolic	metabolic	NOUN
admet-1476	291	17	disease	disease	NOUN
admet-1476	291	18	.	.	PUNCT
admet-1476	292	1	nutrients	nutrient	NOUN
admet-1476	292	2	13	13	NUM
admet-1476	292	3	(	(	PUNCT
admet-1476	292	4	2021	2021	NUM
admet-1476	292	5	)	)	PUNCT
admet-1476	292	6	1	1	NUM
admet-1476	292	7	-	-	SYM
admet-1476	292	8	16	16	NUM
admet-1476	292	9	.	.	PUNCT
admet-1476	293	1	https://doi.org/10.3390/nu13041104	https://doi.org/10.3390/nu13041104	X
admet-1476	294	1	[	[	X
admet-1476	294	2	8	8	NUM
admet-1476	294	3	]	]	SYM
admet-1476	294	4	riethorst	riethorst	PROPN
admet-1476	294	5	,	,	PUNCT
admet-1476	294	6	r.	r.	PROPN
admet-1476	294	7	mols	mols	PROPN
admet-1476	294	8	,	,	PUNCT
admet-1476	294	9	g.	g.	PROPN
admet-1476	294	10	duchateau	duchateau	PROPN
admet-1476	294	11	,	,	PUNCT
admet-1476	294	12	j.	j.	PROPN
admet-1476	294	13	tack	tack	PROPN
admet-1476	294	14	,	,	PUNCT
admet-1476	294	15	j.	j.	PROPN
admet-1476	294	16	brouwers	brouwers	PROPN
admet-1476	294	17	,	,	PUNCT
admet-1476	294	18	p.	p.	NOUN
admet-1476	294	19	augustijns	augustijns	NOUN
admet-1476	294	20	.	.	PUNCT
admet-1476	295	1	characterization	characterization	NOUN
admet-1476	295	2	of	of	ADP
admet-1476	295	3	human	human	ADJ
admet-1476	295	4	duodenal	duodenal	ADJ
admet-1476	295	5	fluids	fluid	NOUN
admet-1476	295	6	in	in	ADP
admet-1476	295	7	fasted	fast	VERB
admet-1476	295	8	and	and	CCONJ
admet-1476	295	9	fed	feed	VERB
admet-1476	295	10	state	state	NOUN
admet-1476	295	11	conditions	condition	NOUN
admet-1476	295	12	.	.	PUNCT
admet-1476	296	1	journal	journal	NOUN
admet-1476	296	2	of	of	ADP
admet-1476	296	3	pharmaceutical	pharmaceutical	PROPN
admet-1476	296	4	sciences	science	NOUN
admet-1476	296	5	105	105	NUM
admet-1476	296	6	(	(	PUNCT
admet-1476	296	7	2016	2016	NUM
admet-1476	296	8	)	)	PUNCT
admet-1476	296	9	673–678	673–678	NUM
admet-1476	296	10	.	.	PUNCT
admet-1476	297	1	https://doi.org/10.1002/jps.24603	https://doi.org/10.1002/jps.24603	NOUN
admet-1476	297	2	.	.	PUNCT
admet-1476	298	1	[	[	X
admet-1476	298	2	9	9	NUM
admet-1476	298	3	]	]	PUNCT
admet-1476	298	4	k.	k.	PROPN
admet-1476	298	5	sugano	sugano	PROPN
admet-1476	298	6	.	.	PUNCT
admet-1476	299	1	computational	computational	ADJ
admet-1476	299	2	oral	oral	ADJ
admet-1476	299	3	absorption	absorption	NOUN
admet-1476	299	4	simulation	simulation	NOUN
admet-1476	299	5	for	for	ADP
admet-1476	299	6	low	low	ADJ
admet-1476	299	7	-	-	PUNCT
admet-1476	299	8	solubility	solubility	NOUN
admet-1476	299	9	compounds	compound	NOUN
admet-1476	299	10	.	.	PUNCT
admet-1476	300	1	chemistry	chemistry	NOUN
admet-1476	300	2	&	&	CCONJ
admet-1476	300	3	biodiversity	biodiversity	PROPN
admet-1476	300	4	6	6	NUM
admet-1476	300	5	(	(	PUNCT
admet-1476	300	6	2009	2009	NUM
admet-1476	300	7	)	)	PUNCT
admet-1476	300	8	2014	2014	NUM
admet-1476	300	9	-	-	SYM
admet-1476	300	10	2019	2019	NUM
admet-1476	300	11	.	.	PUNCT
admet-1476	301	1	https://doi.org/10.1002/cbdv.v6:1110.1002/cbdv.200900101	https://doi.org/10.1002/cbdv.v6:1110.1002/cbdv.200900101	PROPN
admet-1476	301	2	.	.	PUNCT
admet-1476	302	1	[	[	X
admet-1476	302	2	10	10	NUM
admet-1476	302	3	]	]	PUNCT
admet-1476	302	4	k.	k.	PROPN
admet-1476	302	5	sugano	sugano	PROPN
admet-1476	302	6	,	,	PUNCT
admet-1476	302	7	k.	k.	PROPN
admet-1476	302	8	terada	terada	PROPN
admet-1476	302	9	.	.	PUNCT
admet-1476	303	1	rate	rate	NOUN
admet-1476	303	2	-	-	PUNCT
admet-1476	303	3	and	and	CCONJ
admet-1476	303	4	extent	extent	NOUN
admet-1476	303	5	-	-	PUNCT
admet-1476	303	6	limiting	limit	VERB
admet-1476	303	7	factors	factor	NOUN
admet-1476	303	8	of	of	ADP
admet-1476	303	9	oral	oral	ADJ
admet-1476	303	10	drug	drug	NOUN
admet-1476	303	11	absorption	absorption	NOUN
admet-1476	303	12	:	:	PUNCT
admet-1476	303	13	theory	theory	NOUN
admet-1476	303	14	and	and	CCONJ
admet-1476	303	15	applications	application	NOUN
admet-1476	303	16	.	.	PUNCT
admet-1476	304	1	journal	journal	NOUN
admet-1476	304	2	of	of	ADP
admet-1476	304	3	pharmaceutical	pharmaceutical	PROPN
admet-1476	304	4	sciences	science	NOUN
admet-1476	304	5	104	104	NUM
admet-1476	304	6	(	(	PUNCT
admet-1476	304	7	2015	2015	NUM
admet-1476	304	8	)	)	PUNCT
admet-1476	304	9	2777	2777	NUM
admet-1476	304	10	-	-	SYM
admet-1476	304	11	2788	2788	NUM
admet-1476	304	12	.	.	PUNCT
admet-1476	305	1	https://doi.org/10.1002/jps.24391	https://doi.org/10.1002/jps.24391	NOUN
admet-1476	305	2	.	.	PUNCT
admet-1476	306	1	[	[	X
admet-1476	306	2	11	11	NUM
admet-1476	306	3	]	]	X
admet-1476	306	4	j.m	j.m	PROPN
admet-1476	306	5	.	.	PROPN
admet-1476	306	6	custodio	custodio	PROPN
admet-1476	306	7	,	,	PUNCT
admet-1476	306	8	c.y	c.y	PROPN
admet-1476	306	9	.	.	PROPN
admet-1476	306	10	wu	wu	PROPN
admet-1476	306	11	,	,	PUNCT
admet-1476	306	12	l.z	l.z	PROPN
admet-1476	306	13	.	.	PROPN
admet-1476	306	14	benet	benet	PROPN
admet-1476	306	15	.	.	PUNCT
admet-1476	306	16	predicting	predict	VERB
admet-1476	306	17	drug	drug	NOUN
admet-1476	306	18	disposition	disposition	NOUN
admet-1476	306	19	,	,	PUNCT
admet-1476	306	20	absorption	absorption	NOUN
admet-1476	306	21	/	/	SYM
admet-1476	306	22	elimination	elimination	NOUN
admet-1476	306	23	/	/	SYM
admet-1476	306	24	transporter	transporter	NOUN
admet-1476	306	25	interplay	interplay	NOUN
admet-1476	306	26	and	and	CCONJ
admet-1476	306	27	the	the	DET
admet-1476	306	28	role	role	NOUN
admet-1476	306	29	of	of	ADP
admet-1476	306	30	food	food	NOUN
admet-1476	306	31	on	on	ADP
admet-1476	306	32	drug	drug	NOUN
admet-1476	306	33	absorption	absorption	NOUN
admet-1476	306	34	.	.	PUNCT
admet-1476	307	1	advance	advance	NOUN
admet-1476	307	2	drug	drug	NOUN
admet-1476	307	3	delivery	delivery	NOUN
admet-1476	307	4	reviews	review	NOUN
admet-1476	307	5	60	60	NUM
admet-1476	307	6	(	(	PUNCT
admet-1476	307	7	2008	2008	NUM
admet-1476	307	8	)	)	PUNCT
admet-1476	307	9	717733	717733	NUM
admet-1476	307	10	.	.	PUNCT
admet-1476	308	1	https://doi:10.1016	https://doi:10.1016	PROPN
admet-1476	308	2	/	/	SYM
admet-1476	308	3	j.addr.2007.08.043	j.addr.2007.08.043	PROPN
admet-1476	308	4	.	.	PUNCT
admet-1476	309	1	[	[	X
admet-1476	309	2	12	12	NUM
admet-1476	309	3	]	]	X
admet-1476	309	4	guidance	guidance	NOUN
admet-1476	309	5	for	for	ADP
admet-1476	309	6	industry	industry	NOUN
admet-1476	309	7	:	:	PUNCT
admet-1476	309	8	assessing	assess	VERB
admet-1476	309	9	the	the	DET
admet-1476	309	10	effects	effect	NOUN
admet-1476	309	11	of	of	ADP
admet-1476	309	12	food	food	NOUN
admet-1476	309	13	on	on	ADP
admet-1476	309	14	drugs	drug	NOUN
admet-1476	309	15	in	in	ADP
admet-1476	309	16	inds	ind	NOUN
admet-1476	309	17	and	and	CCONJ
admet-1476	309	18	ndaclinical	ndaclinical	ADJ
admet-1476	309	19	pharmacology	pharmacology	NOUN
admet-1476	309	20	considerations	consideration	NOUN
admet-1476	309	21	,	,	PUNCT
admet-1476	309	22	https://www.fda.gov/regulatory-information/search-fda-guidancedocuments/assessing-effects-food-drugs-inds-and-ndas-clinical-pharmacology-considerations	https://www.fda.gov/regulatory-information/search-fda-guidancedocuments/assessing-effects-food-drugs-inds-and-ndas-clinical-pharmacology-consideration	NOUN
admet-1476	309	23	(	(	PUNCT
admet-1476	309	24	accessed	access	VERB
admet-1476	309	25	21	21	NUM
admet-1476	309	26	june	june	PROPN
admet-1476	309	27	,	,	PUNCT
admet-1476	309	28	2022	2022	NUM
admet-1476	309	29	)	)	PUNCT
admet-1476	309	30	.	.	PUNCT
admet-1476	310	1	[	[	X
admet-1476	310	2	13	13	NUM
admet-1476	310	3	]	]	SYM
admet-1476	310	4	guidance	guidance	NOUN
admet-1476	310	5	for	for	ADP
admet-1476	310	6	industry	industry	NOUN
admet-1476	310	7	:	:	PUNCT
admet-1476	310	8	the	the	DET
admet-1476	310	9	use	use	NOUN
admet-1476	310	10	of	of	ADP
admet-1476	310	11	physiologically	physiologically	ADV
admet-1476	310	12	based	base	VERB
admet-1476	310	13	pharmacokinetic	pharmacokinetic	ADJ
admet-1476	310	14	analyses	analysis	NOUN
admet-1476	310	15	biopharmaceutics	biopharmaceutics	NOUN
admet-1476	310	16	applications	application	NOUN
admet-1476	310	17	for	for	ADP
admet-1476	310	18	oral	oral	ADJ
admet-1476	310	19	drug	drug	NOUN
admet-1476	310	20	product	product	NOUN
admet-1476	310	21	development	development	NOUN
admet-1476	310	22	,	,	PUNCT
admet-1476	310	23	manufacturing	manufacturing	NOUN
admet-1476	310	24	changes	change	NOUN
admet-1476	310	25	,	,	PUNCT
admet-1476	310	26	and	and	CCONJ
admet-1476	310	27	controls	control	NOUN
admet-1476	310	28	,	,	PUNCT
admet-1476	310	29	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/usephysiologically-based-pharmacokinetic-analyses-biopharmaceutics-applications-oral-drug-product	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/usephysiologically-based-pharmacokinetic-analyses-biopharmaceutics-applications-oral-drug-product	NOUN
admet-1476	310	30	(	(	PUNCT
admet-1476	310	31	accessed	access	VERB
admet-1476	310	32	21	21	NUM
admet-1476	310	33	june	june	PROPN
admet-1476	310	34	,	,	PUNCT
admet-1476	310	35	2022	2022	NUM
admet-1476	310	36	)	)	PUNCT
admet-1476	310	37	.	.	PUNCT
admet-1476	311	1	[	[	X
admet-1476	311	2	14	14	NUM
admet-1476	311	3	]	]	PUNCT
admet-1476	311	4	t.	t.	PROPN
admet-1476	311	5	zhang	zhang	PROPN
admet-1476	311	6	,	,	PUNCT
admet-1476	311	7	e.	e.	PROPN
admet-1476	311	8	wells	wells	PROPN
admet-1476	311	9	.	.	PUNCT
admet-1476	312	1	a	a	DET
admet-1476	312	2	review	review	NOUN
admet-1476	312	3	of	of	ADP
admet-1476	312	4	current	current	ADJ
admet-1476	312	5	methods	method	NOUN
admet-1476	312	6	for	for	ADP
admet-1476	312	7	food	food	NOUN
admet-1476	312	8	effect	effect	NOUN
admet-1476	312	9	prediction	prediction	NOUN
admet-1476	312	10	during	during	ADP
admet-1476	312	11	drug	drug	NOUN
admet-1476	312	12	development	development	NOUN
admet-1476	312	13	,	,	PUNCT
admet-1476	312	14	current	current	ADJ
admet-1476	312	15	pharmacology	pharmacology	NOUN
admet-1476	312	16	reports	report	NOUN
admet-1476	312	17	.	.	PUNCT
admet-1476	313	1	6	6	NUM
admet-1476	313	2	(	(	PUNCT
admet-1476	313	3	2020	2020	NUM
admet-1476	313	4	)	)	PUNCT
admet-1476	313	5	267–279	267–279	NUM
admet-1476	313	6	.	.	PUNCT
admet-1476	314	1	https://doi.org/10.1007/s40495-020-00230-9	https://doi.org/10.1007/s40495-020-00230-9	NUM
admet-1476	314	2	.	.	PUNCT
admet-1476	315	1	[	[	X
admet-1476	315	2	15	15	NUM
admet-1476	315	3	]	]	X
admet-1476	315	4	c.	c.	PROPN
admet-1476	315	5	pentafragka	pentafragka	PROPN
admet-1476	315	6	,	,	PUNCT
admet-1476	315	7	m.	m.	NOUN
admet-1476	315	8	symillides	symillide	NOUN
admet-1476	315	9	,	,	PUNCT
admet-1476	315	10	m.	m.	NOUN
admet-1476	315	11	mcallister	mcallister	PROPN
admet-1476	315	12	,	,	PUNCT
admet-1476	315	13	j.	j.	PROPN
admet-1476	315	14	dressman	dressman	PROPN
admet-1476	315	15	,	,	PUNCT
admet-1476	315	16	m.	m.	PROPN
admet-1476	315	17	vertzoni	vertzoni	PROPN
admet-1476	315	18	,	,	PUNCT
admet-1476	315	19	c.	c.	PROPN
admet-1476	315	20	reppas	reppas	PROPN
admet-1476	315	21	.	.	PUNCT
admet-1476	316	1	the	the	DET
admet-1476	316	2	impact	impact	NOUN
admet-1476	316	3	of	of	ADP
admet-1476	316	4	food	food	NOUN
admet-1476	316	5	intake	intake	NOUN
admet-1476	316	6	on	on	ADP
admet-1476	316	7	the	the	DET
admet-1476	316	8	luminal	luminal	ADJ
admet-1476	316	9	environment	environment	NOUN
admet-1476	316	10	and	and	CCONJ
admet-1476	316	11	performance	performance	NOUN
admet-1476	316	12	of	of	ADP
admet-1476	316	13	oral	oral	ADJ
admet-1476	316	14	drug	drug	NOUN
admet-1476	316	15	products	product	NOUN
admet-1476	316	16	with	with	ADP
admet-1476	316	17	a	a	DET
admet-1476	316	18	view	view	NOUN
admet-1476	316	19	to	to	ADP
admet-1476	316	20	in	in	ADP
admet-1476	316	21	vitro	vitro	X
admet-1476	316	22	and	and	CCONJ
admet-1476	316	23	in	in	ADP
admet-1476	316	24	silico	silico	NOUN
admet-1476	316	25	simulations	simulation	NOUN
admet-1476	316	26	:	:	PUNCT
admet-1476	316	27	a	a	DET
admet-1476	316	28	pearrl	pearrl	PROPN
admet-1476	316	29	review	review	NOUN
admet-1476	316	30	.	.	PUNCT
admet-1476	317	1	journal	journal	PROPN
admet-1476	317	2	of	of	ADP
admet-1476	317	3	pharmacy	pharmacy	NOUN
admet-1476	317	4	and	and	CCONJ
admet-1476	317	5	pharmacology	pharmacology	NOUN
admet-1476	317	6	71	71	NUM
admet-1476	317	7	(	(	PUNCT
admet-1476	317	8	2019	2019	NUM
admet-1476	317	9	)	)	PUNCT
admet-1476	318	1	557–580	557–580	NUM
admet-1476	318	2	.	.	PUNCT
admet-1476	318	3	https://doi.org/10.1111/jphp.12999	https://doi.org/10.1111/jphp.12999	NOUN
admet-1476	318	4	.	.	PUNCT
admet-1476	319	1	[	[	X
admet-1476	319	2	16	16	NUM
admet-1476	319	3	]	]	X
admet-1476	319	4	m.	m.	NOUN
admet-1476	319	5	vertzoni	vertzoni	PROPN
admet-1476	319	6	,	,	PUNCT
admet-1476	319	7	n.	n.	PROPN
admet-1476	319	8	fotaki	fotaki	PROPN
admet-1476	319	9	,	,	PUNCT
admet-1476	319	10	e.	e.	PROPN
admet-1476	319	11	nicolaides	nicolaides	PROPN
admet-1476	319	12	,	,	PUNCT
admet-1476	319	13	c.	c.	PROPN
admet-1476	319	14	reppas	reppas	PROPN
admet-1476	319	15	,	,	PUNCT
admet-1476	319	16	e.	e.	PROPN
admet-1476	319	17	kostewicz	kostewicz	PROPN
admet-1476	319	18	,	,	PUNCT
admet-1476	319	19	e.	e.	PROPN
admet-1476	319	20	stippler	stippler	PROPN
admet-1476	319	21	,	,	PUNCT
admet-1476	319	22	c.	c.	PROPN
admet-1476	319	23	leuner	leuner	PROPN
admet-1476	319	24	,	,	PUNCT
admet-1476	319	25	j.	j.	PROPN
admet-1476	319	26	dressman	dressman	PROPN
admet-1476	319	27	.	.	PUNCT
admet-1476	320	1	dissolution	dissolution	PROPN
admet-1476	320	2	media	medium	NOUN
admet-1476	320	3	simulating	simulate	VERB
admet-1476	320	4	the	the	DET
admet-1476	320	5	intralumenal	intralumenal	ADJ
admet-1476	320	6	composition	composition	NOUN
admet-1476	320	7	of	of	ADP
admet-1476	320	8	the	the	DET
admet-1476	320	9	small	small	ADJ
admet-1476	320	10	intestine	intestine	NOUN
admet-1476	320	11	:	:	PUNCT
admet-1476	320	12	physiological	physiological	ADJ
admet-1476	320	13	issues	issue	NOUN
admet-1476	320	14	and	and	CCONJ
admet-1476	320	15	practical	practical	ADJ
admet-1476	320	16	aspects	aspect	NOUN
admet-1476	320	17	.	.	PUNCT
admet-1476	321	1	journal	journal	NOUN
admet-1476	321	2	of	of	ADP
admet-1476	321	3	pharmacy	pharmacy	NOUN
admet-1476	321	4	and	and	CCONJ
admet-1476	321	5	pharmacology	pharmacology	NOUN
admet-1476	321	6	56	56	NUM
admet-1476	321	7	(	(	PUNCT
admet-1476	321	8	2004	2004	NUM
admet-1476	321	9	)	)	PUNCT
admet-1476	321	10	453	453	NUM
admet-1476	321	11	-	-	SYM
admet-1476	321	12	462	462	NUM
admet-1476	321	13	.	.	PUNCT
admet-1476	321	14	https://doi.org/10.1211/0022357022935	https://doi.org/10.1211/0022357022935	PROPN
admet-1476	321	15	.	.	PUNCT
admet-1476	322	1	[	[	X
admet-1476	322	2	17	17	NUM
admet-1476	322	3	]	]	PUNCT
admet-1476	322	4	avdeef	avdeef	NOUN
admet-1476	322	5	,	,	PUNCT
admet-1476	322	6	absorption	absorption	NOUN
admet-1476	322	7	and	and	CCONJ
admet-1476	322	8	drug	drug	NOUN
admet-1476	322	9	development	development	NOUN
admet-1476	322	10	,	,	PUNCT
admet-1476	322	11	john	john	PROPN
admet-1476	322	12	wiley	wiley	PROPN
admet-1476	322	13	&	&	CCONJ
admet-1476	322	14	sons	sons	PROPN
admet-1476	322	15	,	,	PUNCT
admet-1476	322	16	inc	inc	PROPN
admet-1476	322	17	.	.	PROPN
admet-1476	322	18	,	,	PUNCT
admet-1476	322	19	hoboken	hoboken	PROPN
admet-1476	322	20	,	,	PUNCT
admet-1476	322	21	new	new	PROPN
admet-1476	322	22	jersey	jersey	PROPN
admet-1476	322	23	,	,	PUNCT
admet-1476	322	24	usa	usa	PROPN
admet-1476	322	25	,	,	PUNCT
admet-1476	322	26	2012	2012	NUM
admet-1476	322	27	,	,	PUNCT
admet-1476	322	28	p.	p.	NOUN
admet-1476	322	29	342	342	NUM
admet-1476	322	30	.	.	PUNCT
admet-1476	323	1	isbn	isbn	ADJ
admet-1476	323	2	978	978	NUM
admet-1476	323	3	-	-	SYM
admet-1476	323	4	1	1	NUM
admet-1476	323	5	-	-	PUNCT
admet-1476	323	6	118	118	NUM
admet-1476	323	7	-	-	PUNCT
admet-1476	323	8	05745	05745	NUM
admet-1476	323	9	-	-	SYM
admet-1476	323	10	2	2	NUM
admet-1476	323	11	.	.	PUNCT
admet-1476	324	1	[	[	X
admet-1476	324	2	18	18	NUM
admet-1476	324	3	]	]	PUNCT
admet-1476	324	4	avdeef	avdeef	NOUN
admet-1476	324	5	,	,	PUNCT
admet-1476	324	6	absorption	absorption	NOUN
admet-1476	324	7	and	and	CCONJ
admet-1476	324	8	drug	drug	NOUN
admet-1476	324	9	development	development	NOUN
admet-1476	324	10	,	,	PUNCT
admet-1476	324	11	john	john	PROPN
admet-1476	324	12	wiley	wiley	PROPN
admet-1476	324	13	&	&	CCONJ
admet-1476	324	14	sons	sons	PROPN
admet-1476	324	15	,	,	PUNCT
admet-1476	324	16	inc	inc	PROPN
admet-1476	324	17	.	.	PROPN
admet-1476	324	18	,	,	PUNCT
admet-1476	324	19	hoboken	hoboken	PROPN
admet-1476	324	20	,	,	PUNCT
admet-1476	324	21	new	new	PROPN
admet-1476	324	22	jersey	jersey	PROPN
admet-1476	324	23	,	,	PUNCT
admet-1476	324	24	usa	usa	PROPN
admet-1476	324	25	,	,	PUNCT
admet-1476	324	26	2012	2012	NUM
admet-1476	324	27	,	,	PUNCT
admet-1476	324	28	p.	p.	NOUN
admet-1476	324	29	108	108	NUM
admet-1476	324	30	-	-	SYM
admet-1476	324	31	126	126	NUM
admet-1476	324	32	;	;	PUNCT
admet-1476	324	33	242	242	NUM
admet-1476	324	34	-	-	SYM
admet-1476	324	35	244	244	NUM
admet-1476	324	36	.	.	PUNCT
admet-1476	325	1	isbn	isbn	ADJ
admet-1476	325	2	978	978	NUM
admet-1476	325	3	-	-	SYM
admet-1476	325	4	1	1	NUM
admet-1476	325	5	-	-	PUNCT
admet-1476	325	6	118	118	NUM
admet-1476	325	7	-	-	PUNCT
admet-1476	325	8	05745	05745	NUM
admet-1476	325	9	-	-	SYM
admet-1476	325	10	2	2	NUM
admet-1476	325	11	.	.	PUNCT
admet-1476	326	1	[	[	X
admet-1476	326	2	19	19	NUM
admet-1476	326	3	]	]	PUNCT
admet-1476	326	4	acd/	acd/	PROPN
admet-1476	326	5	labs	lab	NOUN
admet-1476	326	6	.	.	PUNCT
admet-1476	327	1	percepta	percepta	NOUN
admet-1476	327	2	®	®	VERB
admet-1476	327	3	the	the	DET
admet-1476	327	4	platform	platform	NOUN
admet-1476	327	5	for	for	ADP
admet-1476	327	6	in	in	ADP
admet-1476	327	7	silico	silico	NOUN
admet-1476	327	8	molecular	molecular	ADJ
admet-1476	327	9	property	property	NOUN
admet-1476	327	10	calculations	calculation	NOUN
admet-1476	327	11	software	software	NOUN
admet-1476	327	12	,	,	PUNCT
admet-1476	327	13	2016	2016	NUM
admet-1476	327	14	.	.	PUNCT
admet-1476	328	1	[	[	X
admet-1476	328	2	20	20	NUM
admet-1476	328	3	]	]	X
admet-1476	328	4	j.h	j.h	PROPN
admet-1476	328	5	.	.	PROPN
admet-1476	328	6	fagerberg	fagerberg	PROPN
admet-1476	328	7	,	,	PUNCT
admet-1476	328	8	c.a.s	c.a.	VERB
admet-1476	328	9	bergström	bergström	NOUN
admet-1476	328	10	.	.	PUNCT
admet-1476	329	1	intestinal	intestinal	ADJ
admet-1476	329	2	solubility	solubility	NOUN
admet-1476	329	3	and	and	CCONJ
admet-1476	329	4	absorption	absorption	NOUN
admet-1476	329	5	of	of	ADP
admet-1476	329	6	poorly	poorly	ADV
admet-1476	329	7	water	water	NOUN
admet-1476	329	8	soluble	soluble	ADJ
admet-1476	329	9	compounds	compound	NOUN
admet-1476	329	10	:	:	PUNCT
admet-1476	329	11	predictions	prediction	NOUN
admet-1476	329	12	,	,	PUNCT
admet-1476	329	13	challenges	challenge	NOUN
admet-1476	329	14	and	and	CCONJ
admet-1476	329	15	solutions	solution	NOUN
admet-1476	329	16	.	.	PUNCT
admet-1476	330	1	therapeutic	therapeutic	ADJ
admet-1476	330	2	delivery	delivery	NOUN
admet-1476	330	3	6	6	NUM
admet-1476	330	4	(	(	PUNCT
admet-1476	330	5	2015	2015	NUM
admet-1476	330	6	)	)	PUNCT
admet-1476	330	7	935	935	NUM
admet-1476	330	8	-	-	SYM
admet-1476	330	9	959	959	NUM
admet-1476	330	10	.	.	PUNCT
admet-1476	331	1	issn	issn	PROPN
admet-1476	331	2	2041	2041	NUM
admet-1476	331	3	-	-	SYM
admet-1476	331	4	5990	5990	NUM
admet-1476	331	5	.	.	PUNCT
admet-1476	332	1	[	[	X
admet-1476	332	2	21	21	NUM
admet-1476	332	3	]	]	X
admet-1476	332	4	e.	e.	PROPN
admet-1476	332	5	söderlind	söderlind	PROPN
admet-1476	332	6	,	,	PUNCT
admet-1476	332	7	e.	e.	PROPN
admet-1476	332	8	karlsson	karlsson	PROPN
admet-1476	332	9	,	,	PUNCT
admet-1476	332	10	a.	a.	PROPN
admet-1476	332	11	carlsson	carlsson	PROPN
admet-1476	332	12	,	,	PUNCT
admet-1476	332	13	r.	r.	PROPN
admet-1476	332	14	kong	kong	PROPN
admet-1476	332	15	,	,	PUNCT
admet-1476	332	16	a.	a.	PROPN
admet-1476	332	17	lenz	lenz	PROPN
admet-1476	332	18	,	,	PUNCT
admet-1476	332	19	s.	s.	PROPN
admet-1476	332	20	lindborg	lindborg	PROPN
admet-1476	332	21	,	,	PUNCT
admet-1476	332	22	j.	j.	PROPN
admet-1476	332	23	j.	j.	PROPN
admet-1476	332	24	sheng	sheng	PROPN
admet-1476	332	25	.	.	PUNCT
admet-1476	333	1	simulating	simulate	VERB
admet-1476	333	2	fasted	fast	VERB
admet-1476	333	3	human	human	ADJ
admet-1476	333	4	intestinal	intestinal	ADJ
admet-1476	333	5	fluids	fluid	NOUN
admet-1476	333	6	:	:	PUNCT
admet-1476	333	7	understanding	understand	VERB
admet-1476	333	8	the	the	DET
admet-1476	333	9	roles	role	NOUN
admet-1476	333	10	of	of	ADP
admet-1476	333	11	lecithin	lecithin	NOUN
admet-1476	333	12	and	and	CCONJ
admet-1476	333	13	bile	bile	NOUN
admet-1476	333	14	acids	acid	NOUN
admet-1476	333	15	.	.	PUNCT
admet-1476	334	1	molecular	molecular	ADJ
admet-1476	334	2	pharmaceutics	pharmaceutic	NOUN
admet-1476	334	3	7	7	NUM
admet-1476	334	4	(	(	PUNCT
admet-1476	334	5	2010	2010	NUM
admet-1476	334	6	)	)	PUNCT
admet-1476	334	7	1498	1498	NUM
admet-1476	334	8	-	-	SYM
admet-1476	334	9	1507	1507	NUM
admet-1476	334	10	.	.	PUNCT
admet-1476	335	1	https://doi.org/10.1021/mp100144v	https://doi.org/10.1021/mp100144v	VERB
admet-1476	335	2	.	.	PUNCT
admet-1476	336	1	[	[	X
admet-1476	336	2	22	22	NUM
admet-1476	336	3	]	]	X
admet-1476	336	4	y.	y.	PROPN
admet-1476	336	5	shono	shono	PROPN
admet-1476	336	6	,	,	PUNCT
admet-1476	336	7	e.	e.	PROPN
admet-1476	336	8	jantratid	jantratid	PROPN
admet-1476	336	9	,	,	PUNCT
admet-1476	336	10	n.	n.	PROPN
admet-1476	336	11	janssen	janssen	PROPN
admet-1476	336	12	,	,	PUNCT
admet-1476	336	13	f.	f.	PROPN
admet-1476	336	14	kesisoglou	kesisoglou	PROPN
admet-1476	336	15	,	,	PUNCT
admet-1476	336	16	y.	y.	PROPN
admet-1476	336	17	mao	mao	PROPN
admet-1476	336	18	,	,	PUNCT
admet-1476	336	19	m.	m.	PROPN
admet-1476	336	20	vertzoni	vertzoni	PROPN
admet-1476	336	21	,	,	PUNCT
admet-1476	336	22	c.	c.	PROPN
admet-1476	336	23	reppas	reppas	PROPN
admet-1476	336	24	,	,	PUNCT
admet-1476	336	25	j.b	j.b	PROPN
admet-1476	336	26	.	.	PROPN
admet-1476	336	27	dressman	dressman	PROPN
admet-1476	336	28	.	.	PUNCT
admet-1476	337	1	prediction	prediction	NOUN
admet-1476	337	2	of	of	ADP
admet-1476	337	3	food	food	NOUN
admet-1476	337	4	effects	effect	NOUN
admet-1476	337	5	on	on	ADP
admet-1476	337	6	the	the	DET
admet-1476	337	7	absorption	absorption	NOUN
admet-1476	337	8	of	of	ADP
admet-1476	337	9	celecoxib	celecoxib	PROPN
admet-1476	337	10	based	base	VERB
admet-1476	337	11	on	on	ADP
admet-1476	337	12	biorelevant	biorelevant	ADJ
admet-1476	337	13	dissolution	dissolution	NOUN
admet-1476	337	14	testing	testing	NOUN
admet-1476	337	15	coupled	couple	VERB
admet-1476	337	16	with	with	ADP
admet-1476	337	17	physiologically	physiologically	ADV
admet-1476	337	18	based	base	VERB
admet-1476	337	19	pharmacokinetic	pharmacokinetic	ADJ
admet-1476	337	20	modeling	modeling	NOUN
admet-1476	337	21	.	.	PUNCT
admet-1476	338	1	european	european	PROPN
admet-1476	338	2	journal	journal	PROPN
admet-1476	338	3	of	of	ADP
admet-1476	338	4	pharmaceutics	pharmaceutic	NOUN
admet-1476	338	5	and	and	CCONJ
admet-1476	338	6	biopharmaceutics	biopharmaceutic	NOUN
admet-1476	338	7	73	73	NUM
admet-1476	338	8	(	(	PUNCT
admet-1476	338	9	2009	2009	NUM
admet-1476	338	10	)	)	PUNCT
admet-1476	338	11	107	107	NUM
admet-1476	338	12	-	-	SYM
admet-1476	338	13	114	114	NUM
admet-1476	338	14	.	.	PUNCT
admet-1476	339	1	https://doi.org/10.1016/j.ejpb.2009.05.009	https://doi.org/10.1016/j.ejpb.2009.05.009	NUM
admet-1476	339	2	.	.	PUNCT
admet-1476	340	1	https://doi.org/10.3390/nu13041104	https://doi.org/10.3390/nu13041104	DET
admet-1476	340	2	https://doi.org/10.1002/jps.24603	https://doi.org/10.1002/jps.24603	NOUN
admet-1476	340	3	https://doi.org/10.1002/cbdv.v6:1110.1002/cbdv.200900101	https://doi.org/10.1002/cbdv.v6:1110.1002/cbdv.200900101	AUX
admet-1476	340	4	https://doi.org/10.1002/jps.24391	https://doi.org/10.1002/jps.24391	NOUN
admet-1476	340	5	https://doi.org/10.1002/jps.24391	https://doi.org/10.1002/jps.24391	NOUN
admet-1476	340	6	about	about	ADP
admet-1476	340	7	:	:	PUNCT
admet-1476	340	8	blank	blank	ADJ
admet-1476	340	9	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/assessing-effects-food-drugs-inds-and-ndas-clinical-pharmacology-considerations	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/assessing-effects-food-drugs-inds-and-ndas-clinical-pharmacology-consideration	NOUN
admet-1476	340	10	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/assessing-effects-food-drugs-inds-and-ndas-clinical-pharmacology-considerations	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/assessing-effects-food-drugs-inds-and-ndas-clinical-pharmacology-consideration	NOUN
admet-1476	340	11	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/use-physiologically-based-pharmacokinetic-analyses-biopharmaceutics-applications-oral-drug-product	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/use-physiologically-based-pharmacokinetic-analyses-biopharmaceutics-applications-oral-drug-product	NOUN
admet-1476	340	12	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/use-physiologically-based-pharmacokinetic-analyses-biopharmaceutics-applications-oral-drug-product	https://www.fda.gov/regulatory-information/search-fda-guidance-documents/use-physiologically-based-pharmacokinetic-analyses-biopharmaceutics-applications-oral-drug-product	VERB
admet-1476	340	13	https://doi.org/10.1007/s40495-020-00230-9	https://doi.org/10.1007/s40495-020-00230-9	NUM
admet-1476	340	14	https://doi.org/10.1111/jphp.12999	https://doi.org/10.1111/jphp.12999	NOUN
admet-1476	340	15	https://doi.org/10.1021/mp100144v	https://doi.org/10.1021/mp100144v	VERB
admet-1476	340	16	https://doi.org/10.1016/j.ejpb.2009.05.009	https://doi.org/10.1016/j.ejpb.2009.05.009	ADJ
admet-1476	340	17	admet	admet	NOUN
admet-1476	340	18	&	&	CCONJ
admet-1476	340	19	dmpk	dmpk	PROPN
admet-1476	340	20	10(4	10(4	NUM
admet-1476	340	21	)	)	PUNCT
admet-1476	340	22	(	(	PUNCT
admet-1476	340	23	2022	2022	NUM
admet-1476	340	24	)	)	PUNCT
admet-1476	340	25	299	299	NUM
admet-1476	340	26	-	-	SYM
admet-1476	340	27	314	314	NUM
admet-1476	340	28	material	material	NOUN
admet-1476	340	29	sparing	sparing	NOUN
admet-1476	340	30	µflux	µflux	NOUN
admet-1476	340	31	methodology	methodology	NOUN
admet-1476	340	32	doi	doi	NOUN
admet-1476	340	33	:	:	PUNCT
admet-1476	340	34	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	NOUN
admet-1476	340	35	313	313	NUM
admet-1476	340	36	[	[	X
admet-1476	340	37	23	23	NUM
admet-1476	340	38	]	]	X
admet-1476	340	39	j.h	j.h	PROPN
admet-1476	340	40	.	.	PROPN
admet-1476	340	41	fagerberg	fagerberg	PROPN
admet-1476	340	42	,	,	PUNCT
admet-1476	340	43	o.	o.	PROPN
admet-1476	340	44	tsinman	tsinman	NOUN
admet-1476	340	45	,	,	PUNCT
admet-1476	340	46	n.	n.	PROPN
admet-1476	340	47	sun	sun	PROPN
admet-1476	340	48	,	,	PUNCT
admet-1476	340	49	k.	k.	PROPN
admet-1476	340	50	tsinman	tsinman	PROPN
admet-1476	340	51	,	,	PUNCT
admet-1476	340	52	a.	a.	PROPN
admet-1476	340	53	avdeef	avdeef	PROPN
admet-1476	340	54	,	,	PUNCT
admet-1476	340	55	c.a.s	c.a.	VERB
admet-1476	340	56	.	.	PROPN
admet-1476	341	1	bergström	bergström	PROPN
admet-1476	341	2	.	.	PUNCT
admet-1476	342	1	dissolution	dissolution	NOUN
admet-1476	342	2	rate	rate	NOUN
admet-1476	342	3	and	and	CCONJ
admet-1476	342	4	apparent	apparent	ADJ
admet-1476	342	5	solubility	solubility	NOUN
admet-1476	342	6	of	of	ADP
admet-1476	342	7	poorly	poorly	ADV
admet-1476	342	8	soluble	soluble	ADJ
admet-1476	342	9	drugs	drug	NOUN
admet-1476	342	10	in	in	ADP
admet-1476	342	11	biorelevant	biorelevant	ADJ
admet-1476	342	12	dissolution	dissolution	NOUN
admet-1476	342	13	media	medium	NOUN
admet-1476	342	14	.	.	PUNCT
admet-1476	343	1	molecular	molecular	ADJ
admet-1476	343	2	pharmaceutics	pharmaceutic	NOUN
admet-1476	343	3	7	7	NUM
admet-1476	343	4	(	(	PUNCT
admet-1476	343	5	2010	2010	NUM
admet-1476	343	6	):	):	PUNCT
admet-1476	343	7	1419	1419	NUM
admet-1476	343	8	-	-	SYM
admet-1476	343	9	1430	1430	NUM
admet-1476	343	10	.	.	PUNCT
admet-1476	344	1	https://doi.org/10.1021/mp100049	https://doi.org/10.1021/mp100049	DET
admet-1476	344	2	m.	m.	NOUN
admet-1476	344	3	[	[	X
admet-1476	344	4	24	24	NUM
admet-1476	344	5	]	]	X
admet-1476	344	6	y.	y.	PROPN
admet-1476	344	7	kawai	kawai	PROPN
admet-1476	344	8	,	,	PUNCT
admet-1476	344	9	y.	y.	PROPN
admet-1476	344	10	fujii	fujii	PROPN
admet-1476	344	11	,	,	PUNCT
admet-1476	344	12	f.	f.	PROPN
admet-1476	344	13	tabata	tabata	PROPN
admet-1476	344	14	,	,	PUNCT
admet-1476	344	15	j.	j.	PROPN
admet-1476	344	16	ito	ito	PROPN
admet-1476	344	17	,	,	PUNCT
admet-1476	344	18	y.	y.	PROPN
admet-1476	344	19	metsugi	metsugi	PROPN
admet-1476	344	20	,	,	PUNCT
admet-1476	344	21	a.	a.	NOUN
admet-1476	344	22	kameda	kameda	PROPN
admet-1476	344	23	,	,	PUNCT
admet-1476	344	24	k.	k.	PROPN
admet-1476	344	25	akimoto	akimoto	PROPN
admet-1476	344	26	,	,	PUNCT
admet-1476	344	27	m.	m.	PROPN
admet-1476	344	28	takahashi	takahashi	PROPN
admet-1476	344	29	.	.	PUNCT
admet-1476	345	1	profiling	profiling	NOUN
admet-1476	345	2	and	and	CCONJ
admet-1476	345	3	trend	trend	NOUN
admet-1476	345	4	analysis	analysis	NOUN
admet-1476	345	5	of	of	ADP
admet-1476	345	6	food	food	NOUN
admet-1476	345	7	effects	effect	NOUN
admet-1476	345	8	on	on	ADP
admet-1476	345	9	oral	oral	ADJ
admet-1476	345	10	drug	drug	NOUN
admet-1476	345	11	absorption	absorption	NOUN
admet-1476	345	12	considering	consider	VERB
admet-1476	345	13	micelle	micelle	NOUN
admet-1476	345	14	interaction	interaction	NOUN
admet-1476	345	15	and	and	CCONJ
admet-1476	345	16	solubilization	solubilization	NOUN
admet-1476	345	17	by	by	ADP
admet-1476	345	18	bile	bile	NOUN
admet-1476	345	19	micelle	micelle	NOUN
admet-1476	345	20	.	.	PUNCT
admet-1476	346	1	drug	drug	NOUN
admet-1476	346	2	metabolism	metabolism	NOUN
admet-1476	346	3	and	and	CCONJ
admet-1476	346	4	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	346	5	26	26	NUM
admet-1476	346	6	(	(	PUNCT
admet-1476	346	7	2011	2011	NUM
admet-1476	346	8	)	)	PUNCT
admet-1476	346	9	180	180	NUM
admet-1476	346	10	-	-	SYM
admet-1476	346	11	191	191	NUM
admet-1476	346	12	.	.	PUNCT
admet-1476	347	1	https://doi.org/10.2133/dmpk.dmpk-10-rg-098	https://doi.org/10.2133/dmpk.dmpk-10-rg-098	NOUN
admet-1476	347	2	.	.	PUNCT
admet-1476	348	1	[	[	X
admet-1476	348	2	25	25	NUM
admet-1476	348	3	]	]	PUNCT
admet-1476	348	4	k.	k.	PROPN
admet-1476	348	5	takács	takács	PROPN
admet-1476	348	6	-	-	PUNCT
admet-1476	348	7	novák	novák	PROPN
admet-1476	348	8	,	,	PUNCT
admet-1476	348	9	v.	v.	CCONJ
admet-1476	348	10	szőke	szőke	PROPN
admet-1476	348	11	,	,	PUNCT
admet-1476	348	12	g.	g.	PROPN
admet-1476	348	13	völgyi	völgyi	PROPN
admet-1476	348	14	,	,	PUNCT
admet-1476	348	15	p.	p.	NOUN
admet-1476	348	16	horváth	horváth	PROPN
admet-1476	348	17	,	,	PUNCT
admet-1476	348	18	r.	r.	PROPN
admet-1476	348	19	ambrus	ambrus	PROPN
admet-1476	348	20	,	,	PUNCT
admet-1476	348	21	p.	p.	PROPN
admet-1476	348	22	szabó	szabó	PROPN
admet-1476	348	23	-	-	PUNCT
admet-1476	348	24	révész	révész	VERB
admet-1476	348	25	.	.	PUNCT
admet-1476	349	1	biorelevant	biorelevant	PROPN
admet-1476	349	2	solubility	solubility	NOUN
admet-1476	349	3	of	of	ADP
admet-1476	349	4	poorly	poorly	ADV
admet-1476	349	5	soluble	soluble	ADJ
admet-1476	349	6	drugs	drug	NOUN
admet-1476	349	7	:	:	PUNCT
admet-1476	349	8	rivaroxaban	rivaroxaban	NOUN
admet-1476	349	9	,	,	PUNCT
admet-1476	349	10	furosemide	furosemide	ADJ
admet-1476	349	11	,	,	PUNCT
admet-1476	349	12	papaverine	papaverine	NOUN
admet-1476	349	13	and	and	CCONJ
admet-1476	349	14	niflumic	niflumic	ADJ
admet-1476	349	15	acid	acid	NOUN
admet-1476	349	16	.	.	PUNCT
admet-1476	350	1	journal	journal	PROPN
admet-1476	350	2	of	of	ADP
admet-1476	350	3	pharmaceutical	pharmaceutical	NOUN
admet-1476	350	4	and	and	CCONJ
admet-1476	350	5	biomedical	biomedical	ADJ
admet-1476	350	6	analysis	analysis	NOUN
admet-1476	350	7	83	83	NUM
admet-1476	350	8	(	(	PUNCT
admet-1476	350	9	2013	2013	NUM
admet-1476	350	10	)	)	PUNCT
admet-1476	350	11	279	279	NUM
admet-1476	350	12	-	-	SYM
admet-1476	350	13	285	285	NUM
admet-1476	350	14	.	.	PUNCT
admet-1476	351	1	https://doi.org/10.1016/j.jpba.2013.05.011	https://doi.org/10.1016/j.jpba.2013.05.011	NOUN
admet-1476	351	2	.	.	PUNCT
admet-1476	352	1	[	[	X
admet-1476	352	2	26	26	NUM
admet-1476	352	3	]	]	X
admet-1476	352	4	s.	s.	PROPN
admet-1476	352	5	clarysse	clarysse	PROPN
admet-1476	352	6	,	,	PUNCT
admet-1476	352	7	j.	j.	PROPN
admet-1476	352	8	brouwers	brouwers	PROPN
admet-1476	352	9	,	,	PUNCT
admet-1476	352	10	j.	j.	PROPN
admet-1476	352	11	tack	tack	PROPN
admet-1476	352	12	,	,	PUNCT
admet-1476	352	13	p.	p.	NOUN
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admet-1476	353	1	p.	p.	NOUN
admet-1476	353	2	augustijns	augustijns	NOUN
admet-1476	353	3	.	.	PUNCT
admet-1476	354	1	intestinal	intestinal	ADJ
admet-1476	354	2	drug	drug	NOUN
admet-1476	354	3	solubility	solubility	NOUN
admet-1476	354	4	estimation	estimation	NOUN
admet-1476	354	5	based	base	VERB
admet-1476	354	6	on	on	ADP
admet-1476	354	7	simulated	simulated	ADJ
admet-1476	354	8	intestinal	intestinal	ADJ
admet-1476	354	9	fluids	fluid	NOUN
admet-1476	354	10	:	:	PUNCT
admet-1476	354	11	comparison	comparison	NOUN
admet-1476	354	12	with	with	ADP
admet-1476	354	13	solubility	solubility	NOUN
admet-1476	354	14	in	in	ADP
admet-1476	354	15	human	human	ADJ
admet-1476	354	16	intestinal	intestinal	ADJ
admet-1476	354	17	fluids	fluid	NOUN
admet-1476	354	18	.	.	PUNCT
admet-1476	355	1	european	european	ADJ
admet-1476	355	2	journal	journal	PROPN
admet-1476	355	3	of	of	ADP
admet-1476	355	4	pharmaceutical	pharmaceutical	PROPN
admet-1476	355	5	sciences	science	NOUN
admet-1476	355	6	43	43	NUM
admet-1476	355	7	(	(	PUNCT
admet-1476	355	8	2011	2011	NUM
admet-1476	355	9	)	)	PUNCT
admet-1476	355	10	260	260	NUM
admet-1476	355	11	-	-	SYM
admet-1476	355	12	269	269	NUM
admet-1476	355	13	.	.	PUNCT
admet-1476	356	1	https://doi.org/10.1016/j.ejps.2011.04.016	https://doi.org/10.1016/j.ejps.2011.04.016	PROPN
admet-1476	356	2	.	.	PUNCT
admet-1476	357	1	[	[	X
admet-1476	357	2	27	27	NUM
admet-1476	357	3	]	]	PUNCT
admet-1476	357	4	x.	x.	NOUN
admet-1476	357	5	meng	meng	PROPN
admet-1476	357	6	,	,	PUNCT
admet-1476	357	7	p.	p.	PROPN
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admet-1476	357	9	,	,	PUNCT
admet-1476	357	10	m.	m.	NOUN
admet-1476	357	11	doedée	doedée	PROPN
admet-1476	357	12	,	,	PUNCT
admet-1476	357	13	e.	e.	PROPN
admet-1476	357	14	lin	lin	PROPN
admet-1476	357	15	,	,	PUNCT
admet-1476	357	16	i.	i.	PROPN
admet-1476	357	17	weinryb	weinryb	PROPN
admet-1476	357	18	,	,	PUNCT
admet-1476	357	19	s.t	s.t	PROPN
admet-1476	357	20	.	.	PROPN
admet-1476	357	21	chiang	chiang	PROPN
admet-1476	357	22	,	,	PUNCT
admet-1476	357	23	p.r	p.r	PROPN
admet-1476	357	24	.	.	PROPN
admet-1476	357	25	kowey	kowey	PROPN
admet-1476	357	26	.	.	PUNCT
admet-1476	358	1	bioavailability	bioavailability	NOUN
admet-1476	358	2	of	of	ADP
admet-1476	358	3	amiodarone	amiodarone	NOUN
admet-1476	358	4	tablets	tablet	NOUN
admet-1476	358	5	administered	administer	VERB
admet-1476	358	6	with	with	ADP
admet-1476	358	7	and	and	CCONJ
admet-1476	358	8	without	without	ADP
admet-1476	358	9	food	food	NOUN
admet-1476	358	10	in	in	ADP
admet-1476	358	11	healthy	healthy	ADJ
admet-1476	358	12	subjects	subject	NOUN
admet-1476	358	13	.	.	PUNCT
admet-1476	359	1	the	the	DET
admet-1476	359	2	american	american	PROPN
admet-1476	359	3	journal	journal	PROPN
admet-1476	359	4	of	of	ADP
admet-1476	359	5	cardiology	cardiology	NOUN
admet-1476	359	6	87	87	NUM
admet-1476	359	7	(	(	PUNCT
admet-1476	359	8	2001	2001	NUM
admet-1476	359	9	)	)	PUNCT
admet-1476	359	10	432	432	NUM
admet-1476	359	11	-	-	SYM
admet-1476	359	12	435	435	NUM
admet-1476	359	13	.	.	PUNCT
admet-1476	360	1	https://doi.org/10.1016/s0002-9149(00)01396-5	https://doi.org/10.1016/s0002-9149(00)01396-5	PROPN
admet-1476	360	2	.	.	PUNCT
admet-1476	361	1	[	[	X
admet-1476	361	2	28	28	NUM
admet-1476	361	3	]	]	X
admet-1476	361	4	v.	v.	CCONJ
admet-1476	361	5	bakatselou	bakatselou	PROPN
admet-1476	361	6	,	,	PUNCT
admet-1476	361	7	r.c	r.c	PROPN
admet-1476	361	8	.	.	PROPN
admet-1476	361	9	oppenheim	oppenheim	PROPN
admet-1476	361	10	,	,	PUNCT
admet-1476	361	11	j.b	j.b	PROPN
admet-1476	361	12	.	.	PROPN
admet-1476	361	13	dressman	dressman	PROPN
admet-1476	361	14	.	.	PUNCT
admet-1476	362	1	solubilization	solubilization	NOUN
admet-1476	362	2	and	and	CCONJ
admet-1476	362	3	wetting	wet	VERB
admet-1476	362	4	effects	effect	NOUN
admet-1476	362	5	of	of	ADP
admet-1476	362	6	bile	bile	NOUN
admet-1476	362	7	salts	salt	NOUN
admet-1476	362	8	on	on	ADP
admet-1476	362	9	the	the	DET
admet-1476	362	10	dissolution	dissolution	NOUN
admet-1476	362	11	of	of	ADP
admet-1476	362	12	steroids	steroid	NOUN
admet-1476	362	13	.	.	PUNCT
admet-1476	363	1	pharmaceutical	pharmaceutical	ADJ
admet-1476	363	2	research	research	NOUN
admet-1476	363	3	,	,	PUNCT
admet-1476	363	4	8	8	NUM
admet-1476	363	5	(	(	PUNCT
admet-1476	363	6	1991	1991	NUM
admet-1476	363	7	)	)	PUNCT
admet-1476	363	8	1461–1469	1461–1469	NUM
admet-1476	363	9	.	.	PUNCT
admet-1476	364	1	https://doi.org/10.1023/a:1015877929381	https://doi.org/10.1023/a:1015877929381	INTJ
admet-1476	364	2	.	.	PUNCT
admet-1476	365	1	[	[	X
admet-1476	365	2	29	29	NUM
admet-1476	365	3	]	]	X
admet-1476	365	4	s.k	s.k	PROPN
admet-1476	365	5	.	.	PROPN
admet-1476	365	6	paulson	paulson	PROPN
admet-1476	365	7	,	,	PUNCT
admet-1476	365	8	b.v	b.v	PROPN
admet-1476	365	9	.	.	PROPN
admet-1476	365	10	margaret	margaret	PROPN
admet-1476	365	11	,	,	PUNCT
admet-1476	365	12	m.j	m.j	PROPN
admet-1476	365	13	.	.	PROPN
admet-1476	365	14	susan	susan	PROPN
admet-1476	365	15	,	,	PUNCT
admet-1476	365	16	y.	y.	PROPN
admet-1476	365	17	lawal	lawal	PROPN
admet-1476	365	18	,	,	PUNCT
admet-1476	365	19	c.j	c.j	PROPN
admet-1476	365	20	.	.	PROPN
admet-1476	365	21	gresk	gresk	PROPN
admet-1476	365	22	,	,	PUNCT
admet-1476	365	23	b.	b.	PROPN
admet-1476	365	24	yan	yan	PROPN
admet-1476	365	25	,	,	PUNCT
admet-1476	365	26	t.j	t.j	PROPN
admet-1476	365	27	.	.	PROPN
admet-1476	365	28	maziasz	maziasz	PROPN
admet-1476	365	29	,	,	PUNCT
admet-1476	365	30	c.s	c.s	PROPN
admet-1476	365	31	.	.	PROPN
admet-1476	365	32	cook	cook	PROPN
admet-1476	365	33	,	,	PUNCT
admet-1476	365	34	a.	a.	PROPN
admet-1476	365	35	karim	karim	PROPN
admet-1476	365	36	.	.	PUNCT
admet-1476	366	1	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	366	2	of	of	ADP
admet-1476	366	3	celecoxib	celecoxib	NOUN
admet-1476	366	4	after	after	ADP
admet-1476	366	5	oral	oral	ADJ
admet-1476	366	6	administration	administration	NOUN
admet-1476	366	7	in	in	ADP
admet-1476	366	8	dogs	dog	NOUN
admet-1476	366	9	and	and	CCONJ
admet-1476	366	10	humans	human	NOUN
admet-1476	366	11	:	:	PUNCT
admet-1476	366	12	effect	effect	NOUN
admet-1476	366	13	of	of	ADP
admet-1476	366	14	food	food	NOUN
admet-1476	366	15	and	and	CCONJ
admet-1476	366	16	site	site	NOUN
admet-1476	366	17	of	of	ADP
admet-1476	366	18	absorption	absorption	NOUN
admet-1476	366	19	.	.	PUNCT
admet-1476	367	1	journal	journal	PROPN
admet-1476	367	2	of	of	ADP
admet-1476	367	3	pharmacology	pharmacology	NOUN
admet-1476	367	4	and	and	CCONJ
admet-1476	367	5	experimental	experimental	ADJ
admet-1476	367	6	therapeutics	therapeutic	NOUN
admet-1476	367	7	297	297	NUM
admet-1476	367	8	(	(	PUNCT
admet-1476	367	9	2001	2001	NUM
admet-1476	367	10	)	)	PUNCT
admet-1476	367	11	638	638	NUM
admet-1476	367	12	-	-	SYM
admet-1476	367	13	645	645	NUM
admet-1476	367	14	.	.	PUNCT
admet-1476	368	1	https://jpet.aspetjournals.org/content/297/2/638/tab-article-info	https://jpet.aspetjournals.org/content/297/2/638/tab-article-info	NOUN
admet-1476	368	2	.	.	PUNCT
admet-1476	369	1	[	[	X
admet-1476	369	2	30	30	NUM
admet-1476	369	3	]	]	X
admet-1476	369	4	w.n	w.n	PROPN
admet-1476	369	5	.	.	PROPN
admet-1476	369	6	charman	charman	PROPN
admet-1476	369	7	,	,	PUNCT
admet-1476	369	8	m.c	m.c	PROPN
admet-1476	369	9	.	.	PROPN
admet-1476	369	10	rogge	rogge	PROPN
admet-1476	369	11	,	,	PUNCT
admet-1476	369	12	a.w	a.w	PROPN
admet-1476	369	13	.	.	PROPN
admet-1476	369	14	boddy	boddy	PROPN
admet-1476	369	15	,	,	PUNCT
admet-1476	369	16	b.m	b.m	PROPN
admet-1476	369	17	.	.	PROPN
admet-1476	369	18	berger	berger	PROPN
admet-1476	369	19	.	.	PUNCT
admet-1476	370	1	effect	effect	NOUN
admet-1476	370	2	of	of	ADP
admet-1476	370	3	food	food	NOUN
admet-1476	370	4	and	and	CCONJ
admet-1476	370	5	a	a	DET
admet-1476	370	6	monoglyceride	monoglyceride	NOUN
admet-1476	370	7	emulsion	emulsion	NOUN
admet-1476	370	8	formulation	formulation	NOUN
admet-1476	370	9	on	on	ADP
admet-1476	370	10	danazol	danazol	ADJ
admet-1476	370	11	bioavailability	bioavailability	NOUN
admet-1476	370	12	.	.	PUNCT
admet-1476	371	1	the	the	DET
admet-1476	371	2	journal	journal	NOUN
admet-1476	371	3	of	of	ADP
admet-1476	371	4	clinical	clinical	ADJ
admet-1476	371	5	pharmacology	pharmacology	NOUN
admet-1476	371	6	33	33	NUM
admet-1476	371	7	(	(	PUNCT
admet-1476	371	8	1993	1993	NUM
admet-1476	371	9	)	)	PUNCT
admet-1476	371	10	381	381	NUM
admet-1476	371	11	-	-	SYM
admet-1476	371	12	386	386	NUM
admet-1476	371	13	.	.	PUNCT
admet-1476	372	1	https://doi.org/10.1002/j.1552-4604.1993.tb04673.x	https://doi.org/10.1002/j.1552-4604.1993.tb04673.x	X
admet-1476	372	2	.	.	PUNCT
admet-1476	373	1	[	[	X
admet-1476	373	2	31	31	NUM
admet-1476	373	3	]	]	X
admet-1476	373	4	r.g	r.g	PROPN
admet-1476	373	5	.	.	PROPN
admet-1476	373	6	crounse	crounse	NOUN
admet-1476	373	7	.	.	PUNCT
admet-1476	374	1	human	human	ADJ
admet-1476	374	2	pharmacology	pharmacology	NOUN
admet-1476	374	3	of	of	ADP
admet-1476	374	4	griseofulvin	griseofulvin	NOUN
admet-1476	374	5	:	:	PUNCT
admet-1476	374	6	the	the	DET
admet-1476	374	7	effect	effect	NOUN
admet-1476	374	8	of	of	ADP
admet-1476	374	9	fat	fat	ADJ
admet-1476	374	10	intake	intake	NOUN
admet-1476	374	11	on	on	ADP
admet-1476	374	12	gastrointestinal	gastrointestinal	ADJ
admet-1476	374	13	absorption	absorption	NOUN
admet-1476	374	14	.	.	PUNCT
admet-1476	375	1	journal	journal	NOUN
admet-1476	375	2	of	of	ADP
admet-1476	375	3	investigative	investigative	ADJ
admet-1476	375	4	dermatology	dermatology	NOUN
admet-1476	375	5	37	37	NUM
admet-1476	375	6	(	(	PUNCT
admet-1476	375	7	1961	1961	NUM
admet-1476	375	8	)	)	PUNCT
admet-1476	375	9	529	529	NUM
admet-1476	375	10	-	-	SYM
admet-1476	375	11	533	533	NUM
admet-1476	375	12	.	.	PUNCT
admet-1476	375	13	https://doi.org/10.1038/jid.1961.154	https://doi.org/10.1038/jid.1961.154	VERB
admet-1476	375	14	.	.	PUNCT
admet-1476	376	1	[	[	X
admet-1476	376	2	32	32	NUM
admet-1476	376	3	]	]	PUNCT
admet-1476	376	4	t.	t.	PROPN
admet-1476	376	5	shibuta	shibuta	PROPN
admet-1476	376	6	,	,	PUNCT
admet-1476	376	7	n.	n.	PROPN
admet-1476	376	8	inotsume	inotsume	PROPN
admet-1476	376	9	,	,	PUNCT
admet-1476	376	10	z.r	z.r	PROPN
admet-1476	376	11	.	.	PROPN
admet-1476	376	12	iwaoku	iwaoku	PROPN
admet-1476	376	13	,	,	PUNCT
admet-1476	376	14	m.	m.	PROPN
admet-1476	376	15	nakano	nakano	PROPN
admet-1476	376	16	.	.	PUNCT
admet-1476	377	1	influence	influence	NOUN
admet-1476	377	2	of	of	ADP
admet-1476	377	3	food	food	NOUN
admet-1476	377	4	on	on	ADP
admet-1476	377	5	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	377	6	and	and	CCONJ
admet-1476	377	7	pharmacodynamics	pharmacodynamic	NOUN
admet-1476	377	8	of	of	ADP
admet-1476	377	9	furosemide	furosemide	ADJ
admet-1476	377	10	.	.	PUNCT
admet-1476	378	1	hospital	hospital	NOUN
admet-1476	378	2	pharmacy	pharmacy	NOUN
admet-1476	378	3	14	14	NUM
admet-1476	378	4	(	(	PUNCT
admet-1476	378	5	1988	1988	NUM
admet-1476	378	6	)	)	PUNCT
admet-1476	378	7	12	12	NUM
admet-1476	378	8	-	-	SYM
admet-1476	378	9	16	16	NUM
admet-1476	378	10	.	.	PUNCT
admet-1476	379	1	https://doi.org/10.5649/jjphcs1975.14.12	https://doi.org/10.5649/jjphcs1975.14.12	NOUN
admet-1476	379	2	.	.	PUNCT
admet-1476	380	1	[	[	X
admet-1476	380	2	33	33	NUM
admet-1476	380	3	]	]	X
admet-1476	380	4	y.f	y.f	PROPN
admet-1476	380	5	.	.	PROPN
admet-1476	380	6	shiau	shiau	PROPN
admet-1476	380	7	,	,	PUNCT
admet-1476	380	8	p.	p.	PROPN
admet-1476	380	9	fernandez	fernandez	PROPN
admet-1476	380	10	,	,	PUNCT
admet-1476	380	11	m.j	m.j	PROPN
admet-1476	380	12	.	.	PROPN
admet-1476	380	13	jackson	jackson	PROPN
admet-1476	380	14	,	,	PUNCT
admet-1476	380	15	s.	s.	PROPN
admet-1476	380	16	mcmonagle	mcmonagle	PROPN
admet-1476	380	17	.	.	PUNCT
admet-1476	381	1	mechanisms	mechanism	NOUN
admet-1476	381	2	maintaining	maintain	VERB
admet-1476	381	3	a	a	DET
admet-1476	381	4	low	low	ADJ
admet-1476	381	5	-	-	PUNCT
admet-1476	381	6	ph	ph	NOUN
admet-1476	381	7	microclimate	microclimate	NOUN
admet-1476	381	8	in	in	ADP
admet-1476	381	9	the	the	DET
admet-1476	381	10	intestine	intestine	NOUN
admet-1476	381	11	.	.	PUNCT
admet-1476	382	1	american	american	ADJ
admet-1476	382	2	journal	journal	PROPN
admet-1476	382	3	of	of	ADP
admet-1476	382	4	physiology	physiology	NOUN
admet-1476	382	5	-	-	PUNCT
admet-1476	382	6	gastrointestinal	gastrointestinal	ADJ
admet-1476	382	7	and	and	CCONJ
admet-1476	382	8	liver	liver	NOUN
admet-1476	382	9	physiology	physiology	NOUN
admet-1476	382	10	248	248	NUM
admet-1476	382	11	(	(	PUNCT
admet-1476	382	12	1985	1985	NUM
admet-1476	382	13	)	)	PUNCT
admet-1476	382	14	g608	g608	PROPN
admet-1476	382	15	-	-	PUNCT
admet-1476	382	16	g617	g617	PROPN
admet-1476	382	17	.	.	PUNCT
admet-1476	383	1	https://doi.org/10.1152/ajpgi.1985.248.6.g608	https://doi.org/10.1152/ajpgi.1985.248.6.g608	X
admet-1476	383	2	.	.	PUNCT
admet-1476	384	1	[	[	X
admet-1476	384	2	34	34	NUM
admet-1476	384	3	]	]	PUNCT
admet-1476	384	4	avdeef	avdeef	NOUN
admet-1476	384	5	,	,	PUNCT
admet-1476	384	6	absorption	absorption	NOUN
admet-1476	384	7	and	and	CCONJ
admet-1476	384	8	drug	drug	NOUN
admet-1476	384	9	development	development	NOUN
admet-1476	384	10	,	,	PUNCT
admet-1476	384	11	john	john	PROPN
admet-1476	384	12	wiley	wiley	PROPN
admet-1476	384	13	&	&	CCONJ
admet-1476	384	14	sons	sons	PROPN
admet-1476	384	15	,	,	PUNCT
admet-1476	384	16	inc	inc	PROPN
admet-1476	384	17	.	.	PROPN
admet-1476	384	18	,	,	PUNCT
admet-1476	384	19	hoboken	hoboken	PROPN
admet-1476	384	20	,	,	PUNCT
admet-1476	384	21	new	new	PROPN
admet-1476	384	22	jersey	jersey	PROPN
admet-1476	384	23	,	,	PUNCT
admet-1476	384	24	usa	usa	PROPN
admet-1476	384	25	,	,	PUNCT
admet-1476	384	26	2012	2012	NUM
admet-1476	384	27	,	,	PUNCT
admet-1476	384	28	p.	p.	NOUN
admet-1476	384	29	466	466	NUM
admet-1476	384	30	.	.	PUNCT
admet-1476	385	1	isbn	isbn	ADJ
admet-1476	385	2	978	978	NUM
admet-1476	385	3	-	-	SYM
admet-1476	385	4	1	1	NUM
admet-1476	385	5	-	-	PUNCT
admet-1476	385	6	118	118	NUM
admet-1476	385	7	-	-	PUNCT
admet-1476	385	8	05745	05745	NUM
admet-1476	385	9	-	-	SYM
admet-1476	385	10	2	2	NUM
admet-1476	385	11	.	.	PUNCT
admet-1476	386	1	[	[	X
admet-1476	386	2	35	35	NUM
admet-1476	386	3	]	]	X
admet-1476	386	4	d.j	d.j	PROPN
admet-1476	386	5	.	.	PROPN
admet-1476	386	6	klein	klein	PROPN
admet-1476	386	7	,	,	PUNCT
admet-1476	386	8	s.	s.	PROPN
admet-1476	386	9	boukouvala	boukouvala	PROPN
admet-1476	386	10	,	,	PUNCT
admet-1476	386	11	e.m	e.m	PROPN
admet-1476	386	12	.	.	PROPN
admet-1476	386	13	mcdonagh	mcdonagh	PROPN
admet-1476	386	14	,	,	PUNCT
admet-1476	386	15	s.r	s.r	PROPN
admet-1476	386	16	.	.	PROPN
admet-1476	386	17	shuldiner	shuldiner	PROPN
admet-1476	386	18	,	,	PUNCT
admet-1476	386	19	n.	n.	PROPN
admet-1476	386	20	laurieri	laurieri	PROPN
admet-1476	386	21	,	,	PUNCT
admet-1476	386	22	c.f	c.f	PROPN
admet-1476	386	23	.	.	PROPN
admet-1476	386	24	thorn	thorn	PROPN
admet-1476	386	25	,	,	PUNCT
admet-1476	386	26	r.b	r.b	PROPN
admet-1476	386	27	.	.	PROPN
admet-1476	386	28	altman	altman	PROPN
admet-1476	386	29	,	,	PUNCT
admet-1476	386	30	t.e	t.e	PROPN
admet-1476	386	31	.	.	PROPN
admet-1476	386	32	klein	klein	PROPN
admet-1476	386	33	.	.	PUNCT
admet-1476	387	1	pharmgkb	pharmgkb	PROPN
admet-1476	387	2	summary	summary	NOUN
admet-1476	387	3	:	:	PUNCT
admet-1476	387	4	isoniazid	isoniazid	PROPN
admet-1476	387	5	pathway	pathway	NOUN
admet-1476	387	6	,	,	PUNCT
admet-1476	387	7	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	387	8	(	(	PUNCT
admet-1476	387	9	pk	pk	NOUN
admet-1476	387	10	)	)	PUNCT
admet-1476	387	11	.	.	PUNCT
admet-1476	388	1	pharmacogenetics	pharmacogenetic	NOUN
admet-1476	388	2	and	and	CCONJ
admet-1476	388	3	genomics	genomic	NOUN
admet-1476	388	4	26	26	NUM
admet-1476	388	5	(	(	PUNCT
admet-1476	388	6	2016	2016	NUM
admet-1476	388	7	)	)	PUNCT
admet-1476	388	8	,	,	PUNCT
admet-1476	388	9	436	436	NUM
admet-1476	388	10	-	-	SYM
admet-1476	388	11	444	444	NUM
admet-1476	388	12	.	.	PUNCT
admet-1476	389	1	https://doi.org/10.1097%2ffpc.0000000000000232	https://doi.org/10.1097%2ffpc.0000000000000232	NOUN
admet-1476	389	2	.	.	PUNCT
admet-1476	390	1	[	[	X
admet-1476	390	2	36	36	NUM
admet-1476	390	3	]	]	X
admet-1476	390	4	becker	becker	NOUN
admet-1476	390	5	,	,	PUNCT
admet-1476	390	6	j.	j.	PROPN
admet-1476	390	7	b.	b.	PROPN
admet-1476	390	8	dressman	dressman	PROPN
admet-1476	390	9	,	,	PUNCT
admet-1476	390	10	g.	g.	PROPN
admet-1476	390	11	l.	l.	PROPN
admet-1476	390	12	amidon	amidon	PROPN
admet-1476	390	13	,	,	PUNCT
admet-1476	390	14	h.	h.	PROPN
admet-1476	390	15	e.	e.	PROPN
admet-1476	390	16	junginger	junginger	PROPN
admet-1476	390	17	,	,	PUNCT
admet-1476	390	18	s.	s.	PROPN
admet-1476	390	19	kopp	kopp	PROPN
admet-1476	390	20	,	,	PUNCT
admet-1476	390	21	k.	k.	PROPN
admet-1476	390	22	k.	k.	PROPN
admet-1476	390	23	midha	midha	PROPN
admet-1476	390	24	,	,	PUNCT
admet-1476	390	25	v.	v.	ADP
admet-1476	390	26	p.	p.	NOUN
admet-1476	390	27	shah	shah	NOUN
admet-1476	390	28	,	,	PUNCT
admet-1476	390	29	s.	s.	PROPN
admet-1476	390	30	stavchansky	stavchansky	PROPN
admet-1476	390	31	,	,	PUNCT
admet-1476	390	32	d.	d.	PROPN
admet-1476	390	33	m.	m.	PROPN
admet-1476	390	34	barends	barend	VERB
admet-1476	390	35	.	.	PUNCT
admet-1476	391	1	biowaiver	biowaiver	PROPN
admet-1476	391	2	monographs	monograph	NOUN
admet-1476	391	3	for	for	ADP
admet-1476	391	4	immediate	immediate	ADJ
admet-1476	391	5	release	release	NOUN
admet-1476	391	6	solid	solid	ADJ
admet-1476	391	7	oral	oral	ADJ
admet-1476	391	8	dosage	dosage	NOUN
admet-1476	391	9	forms	form	NOUN
admet-1476	391	10	:	:	PUNCT
admet-1476	391	11	isoniazid	isoniazid	NOUN
admet-1476	391	12	.	.	PUNCT
admet-1476	392	1	journal	journal	PROPN
admet-1476	392	2	of	of	ADP
admet-1476	392	3	pharmaceutical	pharmaceutical	PROPN
admet-1476	392	4	sciences	science	NOUN
admet-1476	392	5	96	96	NUM
admet-1476	392	6	(	(	PUNCT
admet-1476	392	7	2007	2007	NUM
admet-1476	392	8	)	)	PUNCT
admet-1476	392	9	522	522	NUM
admet-1476	392	10	-	-	SYM
admet-1476	392	11	531	531	NUM
admet-1476	392	12	.	.	PUNCT
admet-1476	393	1	https://doi.org/10.1002/jps.20765	https://doi.org/10.1002/jps.20765	NOUN
admet-1476	393	2	.	.	PUNCT
admet-1476	394	1	[	[	X
admet-1476	394	2	37	37	NUM
admet-1476	394	3	]	]	X
admet-1476	394	4	c.a	c.a	PROPN
admet-1476	394	5	.	.	PROPN
admet-1476	394	6	peloquin	peloquin	PROPN
admet-1476	394	7	,	,	PUNCT
admet-1476	394	8	r.	r.	PROPN
admet-1476	394	9	namdar	namdar	PROPN
admet-1476	394	10	,	,	PUNCT
admet-1476	394	11	a.	a.	NOUN
admet-1476	394	12	a.	a.	NOUN
admet-1476	394	13	dodge	dodge	PROPN
admet-1476	394	14	,	,	PUNCT
admet-1476	394	15	d.	d.	PROPN
admet-1476	394	16	e.	e.	PROPN
admet-1476	394	17	nix	nix	PROPN
admet-1476	394	18	.	.	PUNCT
admet-1476	395	1	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	395	2	of	of	ADP
admet-1476	395	3	isoniazid	isoniazid	NOUN
admet-1476	395	4	under	under	ADP
admet-1476	395	5	fasting	fast	VERB
admet-1476	395	6	conditions	condition	NOUN
admet-1476	395	7	,	,	PUNCT
admet-1476	395	8	with	with	ADP
admet-1476	395	9	food	food	NOUN
admet-1476	395	10	,	,	PUNCT
admet-1476	395	11	and	and	CCONJ
admet-1476	395	12	with	with	ADP
admet-1476	395	13	antacids	antacid	NOUN
admet-1476	395	14	.	.	PUNCT
admet-1476	396	1	the	the	DET
admet-1476	396	2	international	international	ADJ
admet-1476	396	3	journal	journal	NOUN
admet-1476	396	4	of	of	ADP
admet-1476	396	5	tuberculosis	tuberculosis	NOUN
admet-1476	396	6	and	and	CCONJ
admet-1476	396	7	lung	lung	NOUN
admet-1476	396	8	disease	disease	NOUN
admet-1476	396	9	3	3	NUM
admet-1476	396	10	(	(	PUNCT
admet-1476	396	11	1999	1999	NUM
admet-1476	396	12	)	)	PUNCT
admet-1476	396	13	703	703	NUM
admet-1476	396	14	-	-	SYM
admet-1476	396	15	710	710	NUM
admet-1476	396	16	.	.	PUNCT
admet-1476	397	1	https://www.ingentaconnect.com/content/iuatld/ijtld/1999/00000003/00000008/art00009	https://www.ingentaconnect.com/content/iuatld/ijtld/1999/00000003/00000008/art00009	PROPN
admet-1476	397	2	.	.	PUNCT
admet-1476	398	1	https://doi.org/10.5599/admet.1476	https://doi.org/10.5599/admet.1476	NOUN
admet-1476	398	2	https://doi.org/10.1021/mp100049	https://doi.org/10.1021/mp100049	PROPN
admet-1476	398	3	m	m	VERB
admet-1476	398	4	https://doi.org/10.2133/dmpk.dmpk-10-rg-098	https://doi.org/10.2133/dmpk.dmpk-10-rg-098	PROPN
admet-1476	398	5	https://doi.org/10.1016/j.jpba.2013.05.011	https://doi.org/10.1016/j.jpba.2013.05.011	NOUN
admet-1476	398	6	https://doi.org/10.1016/j.jpba.2013.05.011	https://doi.org/10.1016/j.jpba.2013.05.011	PROPN
admet-1476	398	7	https://doi.org/10.1016/j.ejps.2011.04.016	https://doi.org/10.1016/j.ejps.2011.04.016	PROPN
admet-1476	398	8	https://doi.org/10.1016/s0002-9149(00)01396-5	https://doi.org/10.1016/s0002-9149(00)01396-5	PROPN
admet-1476	398	9	https://doi.org/10.1023/a:1015877929381	https://doi.org/10.1023/a:1015877929381	PROPN
admet-1476	398	10	https://doi.org/10.1023/a:1015877929381	https://doi.org/10.1023/a:1015877929381	PROPN
admet-1476	399	1	https://jpet.aspetjournals.org/content/297/2/638/tab-article-info	https://jpet.aspetjournals.org/content/297/2/638/tab-article-info	NOUN
admet-1476	400	1	https://doi.org/10.1002/j.1552-4604.1993.tb04673.x	https://doi.org/10.1002/j.1552-4604.1993.tb04673.x	PROPN
admet-1476	400	2	https://doi.org/10.1038/jid.1961.154	https://doi.org/10.1038/jid.1961.154	VERB
admet-1476	400	3	https://doi.org/10.1038/jid.1961.154	https://doi.org/10.1038/jid.1961.154	PART
admet-1476	400	4	https://doi.org/10.5649/jjphcs1975.14.12	https://doi.org/10.5649/jjphcs1975.14.12	NOUN
admet-1476	400	5	https://doi.org/10.5649/jjphcs1975.14.12	https://doi.org/10.5649/jjphcs1975.14.12	NOUN
admet-1476	400	6	https://doi.org/10.1152/ajpgi.1985.248.6.g608	https://doi.org/10.1152/ajpgi.1985.248.6.g608	NOUN
admet-1476	400	7	https://doi.org/10.1097%2ffpc.0000000000000232	https://doi.org/10.1097%2ffpc.0000000000000232	PROPN
admet-1476	400	8	https://doi.org/10.1002/jps.20765	https://doi.org/10.1002/jps.20765	PROPN
admet-1476	400	9	https://www.ingentaconnect.com/content/iuatld/ijtld/1999/00000003/00000008/art00009	https://www.ingentaconnect.com/content/iuatld/ijtld/1999/00000003/00000008/art00009	PROPN
admet-1476	401	1	https://www.ingentaconnect.com/content/iuatld/ijtld/1999/00000003/00000008/art00009	https://www.ingentaconnect.com/content/iuatld/ijtld/1999/00000003/00000008/art00009	PROPN
admet-1476	401	2	c.	c.	PROPN
admet-1476	401	3	jankovsky	jankovsky	PROPN
admet-1476	401	4	et	et	PROPN
admet-1476	401	5	al	al	PROPN
admet-1476	401	6	.	.	PROPN
admet-1476	401	7	admet	admet	PROPN
admet-1476	401	8	&	&	CCONJ
admet-1476	401	9	dmpk	dmpk	PROPN
admet-1476	401	10	10(4	10(4	NUM
admet-1476	401	11	)	)	PUNCT
admet-1476	401	12	(	(	PUNCT
admet-1476	401	13	2022	2022	NUM
admet-1476	401	14	)	)	PUNCT
admet-1476	401	15	299	299	NUM
admet-1476	401	16	-	-	SYM
admet-1476	401	17	314	314	NUM
admet-1476	401	18	314	314	NUM
admet-1476	401	19	[	[	X
admet-1476	401	20	38	38	NUM
admet-1476	401	21	]	]	X
admet-1476	401	22	r.c	r.c	PROPN
admet-1476	401	23	.	.	PROPN
admet-1476	401	24	dockens	dockens	PROPN
admet-1476	401	25	,	,	PUNCT
admet-1476	401	26	d.	d.	PROPN
admet-1476	401	27	s.	s.	PROPN
admet-1476	401	28	greene	greene	PROPN
admet-1476	401	29	,	,	PUNCT
admet-1476	401	30	r.	r.	PROPN
admet-1476	401	31	h.	h.	PROPN
admet-1476	401	32	barbhaiya	barbhaiya	PROPN
admet-1476	401	33	.	.	PUNCT
admet-1476	402	1	the	the	DET
admet-1476	402	2	lack	lack	ADJ
admet-1476	402	3	effect	effect	NOUN
admet-1476	402	4	of	of	ADP
admet-1476	402	5	food	food	NOUN
admet-1476	402	6	on	on	ADP
admet-1476	402	7	the	the	DET
admet-1476	402	8	bioavailability	bioavailability	NOUN
admet-1476	402	9	of	of	ADP
admet-1476	402	10	nefazodone	nefazodone	NOUN
admet-1476	402	11	tablets	tablet	NOUN
admet-1476	402	12	.	.	PUNCT
admet-1476	403	1	biopharmaceutics	biopharmaceutics	PROPN
admet-1476	403	2	&	&	CCONJ
admet-1476	403	3	drug	drug	PROPN
admet-1476	403	4	disposition	disposition	NOUN
admet-1476	403	5	17	17	NUM
admet-1476	403	6	(	(	PUNCT
admet-1476	403	7	1996	1996	NUM
admet-1476	403	8	)	)	PUNCT
admet-1476	403	9	135	135	NUM
admet-1476	403	10	-	-	SYM
admet-1476	403	11	143	143	NUM
admet-1476	403	12	.	.	PUNCT
admet-1476	404	1	https://doi.org/10.1002/(sici)1099-081x(199603)17:2<135::aid-bdd947>3.0.co;2-k	https://doi.org/10.1002/(sici)1099-081x(199603)17:2<135::aid-bdd947>3.0.co;2-k	PROPN
admet-1476	404	2	.	.	PUNCT
admet-1476	405	1	[	[	X
admet-1476	405	2	39	39	NUM
admet-1476	405	3	]	]	PUNCT
admet-1476	405	4	r.	r.	PROPN
admet-1476	405	5	holm	holm	PROPN
admet-1476	405	6	,	,	PUNCT
admet-1476	405	7	a.	a.	NOUN
admet-1476	405	8	müllertz	müllertz	PROPN
admet-1476	405	9	,	,	PUNCT
admet-1476	405	10	h.	h.	PROPN
admet-1476	405	11	mu	mu	PROPN
admet-1476	405	12	.	.	PUNCT
admet-1476	405	13	bile	bile	NOUN
admet-1476	405	14	salts	salt	NOUN
admet-1476	405	15	and	and	CCONJ
admet-1476	405	16	their	their	PRON
admet-1476	405	17	importance	importance	NOUN
admet-1476	405	18	for	for	ADP
admet-1476	405	19	drug	drug	NOUN
admet-1476	405	20	absorption	absorption	NOUN
admet-1476	405	21	.	.	PUNCT
admet-1476	406	1	international	international	ADJ
admet-1476	406	2	journal	journal	PROPN
admet-1476	406	3	of	of	ADP
admet-1476	406	4	pharmaceutics	pharmaceutic	NOUN
admet-1476	406	5	453	453	NUM
admet-1476	406	6	(	(	PUNCT
admet-1476	406	7	2013	2013	NUM
admet-1476	406	8	)	)	PUNCT
admet-1476	406	9	44	44	NUM
admet-1476	406	10	-	-	SYM
admet-1476	406	11	55	55	NUM
admet-1476	406	12	.	.	PUNCT
admet-1476	407	1	https://doi.org/10.1016/j.ijpharm.2013.04.003	https://doi.org/10.1016/j.ijpharm.2013.04.003	VERB
admet-1476	407	2	[	[	X
admet-1476	407	3	40	40	NUM
admet-1476	407	4	]	]	PUNCT
admet-1476	407	5	k.	k.	PROPN
admet-1476	407	6	sugano	sugano	PROPN
admet-1476	407	7	,	,	PUNCT
admet-1476	407	8	m.	m.	NOUN
admet-1476	407	9	kataoka	kataoka	PROPN
admet-1476	407	10	,	,	PUNCT
admet-1476	407	11	c.	c.	PROPN
admet-1476	407	12	mathews	mathews	PROPN
admet-1476	407	13	,	,	PUNCT
admet-1476	407	14	s.	s.	PROPN
admet-1476	407	15	yamashita	yamashita	PROPN
admet-1476	407	16	.	.	PUNCT
admet-1476	408	1	prediction	prediction	NOUN
admet-1476	408	2	of	of	ADP
admet-1476	408	3	food	food	NOUN
admet-1476	408	4	effect	effect	NOUN
admet-1476	408	5	by	by	ADP
admet-1476	408	6	bile	bile	NOUN
admet-1476	408	7	micelles	micelle	NOUN
admet-1476	408	8	on	on	ADP
admet-1476	408	9	oral	oral	ADJ
admet-1476	408	10	drug	drug	NOUN
admet-1476	408	11	absorption	absorption	NOUN
admet-1476	408	12	considering	consider	VERB
admet-1476	408	13	free	free	ADJ
admet-1476	408	14	fraction	fraction	NOUN
admet-1476	408	15	in	in	ADP
admet-1476	408	16	intestinal	intestinal	ADJ
admet-1476	408	17	fluid	fluid	NOUN
admet-1476	408	18	.	.	PUNCT
admet-1476	409	1	european	european	ADJ
admet-1476	409	2	journal	journal	PROPN
admet-1476	409	3	of	of	ADP
admet-1476	409	4	pharmaceutical	pharmaceutical	PROPN
admet-1476	409	5	sciences	science	NOUN
admet-1476	409	6	40	40	NUM
admet-1476	409	7	(	(	PUNCT
admet-1476	409	8	2010	2010	NUM
admet-1476	409	9	)	)	PUNCT
admet-1476	409	10	118	118	NUM
admet-1476	409	11	-	-	SYM
admet-1476	409	12	124	124	NUM
admet-1476	409	13	.	.	PUNCT
admet-1476	410	1	https://doi.org/10.1016/j.ejps.2010.03.011	https://doi.org/10.1016/j.ejps.2010.03.011	PROPN
admet-1476	410	2	[	[	X
admet-1476	410	3	41	41	NUM
admet-1476	410	4	]	]	X
admet-1476	410	5	l.	l.	PROPN
admet-1476	410	6	lemberger	lemberger	PROPN
admet-1476	410	7	,	,	PUNCT
admet-1476	410	8	r.	r.	PROPN
admet-1476	410	9	f.	f.	PROPN
admet-1476	410	10	bergstrom	bergstrom	PROPN
admet-1476	410	11	,	,	PUNCT
admet-1476	410	12	r.	r.	PROPN
admet-1476	410	13	l.	l.	PROPN
admet-1476	410	14	wolen	wolen	PROPN
admet-1476	410	15	,	,	PUNCT
admet-1476	410	16	n.	n.	PROPN
admet-1476	410	17	a.	a.	PROPN
admet-1476	410	18	farid	farid	PROPN
admet-1476	410	19	,	,	PUNCT
admet-1476	410	20	g.	g.	PROPN
admet-1476	410	21	g.	g.	PROPN
admet-1476	410	22	enas	enas	PROPN
admet-1476	410	23	,	,	PUNCT
admet-1476	410	24	g.	g.	PROPN
admet-1476	410	25	r.	r.	PROPN
admet-1476	410	26	aronoff	aronoff	PROPN
admet-1476	410	27	.	.	PUNCT
admet-1476	411	1	fluoxetine	fluoxetine	PROPN
admet-1476	411	2	:	:	PUNCT
admet-1476	411	3	clinical	clinical	ADJ
admet-1476	411	4	pharmacology	pharmacology	NOUN
admet-1476	411	5	and	and	CCONJ
admet-1476	411	6	physiologic	physiologic	ADJ
admet-1476	411	7	disposition	disposition	NOUN
admet-1476	411	8	.	.	PUNCT
admet-1476	412	1	the	the	DET
admet-1476	412	2	journal	journal	NOUN
admet-1476	412	3	of	of	ADP
admet-1476	412	4	clinical	clinical	ADJ
admet-1476	412	5	psychiatry	psychiatry	NOUN
admet-1476	412	6	46	46	NUM
admet-1476	412	7	(	(	PUNCT
admet-1476	412	8	1985	1985	NUM
admet-1476	412	9	)	)	PUNCT
admet-1476	412	10	14	14	NUM
admet-1476	412	11	-	-	SYM
admet-1476	412	12	19	19	NUM
admet-1476	412	13	.	.	PUNCT
admet-1476	412	14	pmid	pmid	NOUN
admet-1476	412	15	:	:	PUNCT
admet-1476	412	16	3871765	3871765	NUM
admet-1476	412	17	.	.	PUNCT
admet-1476	413	1	[	[	X
admet-1476	413	2	42	42	NUM
admet-1476	413	3	]	]	X
admet-1476	413	4	j.d	j.d	PROPN
admet-1476	413	5	.	.	PROPN
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admet-1476	413	7	,	,	PUNCT
admet-1476	413	8	c.c	c.c	PROPN
admet-1476	413	9	.	.	PROPN
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admet-1476	413	11	,	,	PUNCT
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admet-1476	413	13	.	.	PROPN
admet-1476	413	14	sondra	sondra	PROPN
admet-1476	413	15	,	,	PUNCT
admet-1476	413	16	d.	d.	PROPN
admet-1476	413	17	cummings	cummings	PROPN
admet-1476	413	18	,	,	PUNCT
admet-1476	413	19	k.	k.	PROPN
admet-1476	413	20	e.	e.	PROPN
admet-1476	413	21	opheim	opheim	PROPN
admet-1476	413	22	,	,	PUNCT
admet-1476	413	23	l.	l.	PROPN
admet-1476	413	24	corey	corey	PROPN
admet-1476	413	25	.	.	PUNCT
admet-1476	413	26	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	413	27	of	of	ADP
admet-1476	413	28	oral	oral	ADJ
admet-1476	413	29	zidovudine	zidovudine	NOUN
admet-1476	413	30	(	(	PUNCT
admet-1476	413	31	azidothymidine	azidothymidine	NOUN
admet-1476	413	32	)	)	PUNCT
admet-1476	413	33	in	in	ADP
admet-1476	413	34	patients	patient	NOUN
admet-1476	413	35	with	with	ADP
admet-1476	413	36	aids	aid	NOUN
admet-1476	413	37	when	when	SCONJ
admet-1476	413	38	administered	administer	VERB
admet-1476	413	39	with	with	ADP
admet-1476	413	40	and	and	CCONJ
admet-1476	413	41	without	without	ADP
admet-1476	413	42	a	a	DET
admet-1476	413	43	high	high	ADJ
admet-1476	413	44	-	-	PUNCT
admet-1476	413	45	fat	fat	NOUN
admet-1476	413	46	meal	meal	NOUN
admet-1476	413	47	.	.	PUNCT
admet-1476	414	1	aids	aids	PROPN
admet-1476	414	2	(	(	PUNCT
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admet-1476	414	4	,	,	PUNCT
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admet-1476	414	7	4	4	NUM
admet-1476	414	8	(	(	PUNCT
admet-1476	414	9	1990	1990	NUM
admet-1476	414	10	)	)	PUNCT
admet-1476	414	11	229	229	NUM
admet-1476	414	12	-	-	SYM
admet-1476	414	13	232	232	NUM
admet-1476	414	14	.	.	PUNCT
admet-1476	415	1	https://doi.org/10.1097/00002030-19900300000008	https://doi.org/10.1097/00002030-19900300000008	NOUN
admet-1476	415	2	.	.	PUNCT
admet-1476	416	1	[	[	X
admet-1476	416	2	43	43	NUM
admet-1476	416	3	]	]	X
admet-1476	416	4	j.	j.	PROPN
admet-1476	416	5	mcewen	mcewen	PROPN
admet-1476	416	6	,	,	PUNCT
admet-1476	416	7	g.	g.	PROPN
admet-1476	416	8	strauch	strauch	PROPN
admet-1476	416	9	,	,	PUNCT
admet-1476	416	10	p.	p.	NOUN
admet-1476	416	11	perles	perles	PROPN
admet-1476	416	12	,	,	PUNCT
admet-1476	416	13	g.	g.	PROPN
admet-1476	416	14	pritchard	pritchard	PROPN
admet-1476	416	15	,	,	PUNCT
admet-1476	416	16	t.	t.	PROPN
admet-1476	416	17	e.	e.	PROPN
admet-1476	416	18	moreland	moreland	PROPN
admet-1476	416	19	,	,	PUNCT
admet-1476	416	20	j.	j.	PROPN
admet-1476	416	21	necciari	necciari	PROPN
admet-1476	416	22	,	,	PUNCT
admet-1476	416	23	j.	j.	PROPN
admet-1476	416	24	p.	p.	PROPN
admet-1476	416	25	dickinson	dickinson	PROPN
admet-1476	416	26	.	.	PUNCT
admet-1476	417	1	clopidogrel	clopidogrel	NOUN
admet-1476	417	2	bioavailability	bioavailability	NOUN
admet-1476	417	3	:	:	PUNCT
admet-1476	417	4	absence	absence	NOUN
admet-1476	417	5	of	of	ADP
admet-1476	417	6	influence	influence	NOUN
admet-1476	417	7	of	of	ADP
admet-1476	417	8	food	food	NOUN
admet-1476	417	9	or	or	CCONJ
admet-1476	417	10	antacids	antacid	NOUN
admet-1476	417	11	.	.	PUNCT
admet-1476	418	1	seminars	seminar	NOUN
admet-1476	418	2	in	in	ADP
admet-1476	418	3	thrombosis	thrombosis	NOUN
admet-1476	418	4	and	and	CCONJ
admet-1476	418	5	hemostasis	hemostasis	NOUN
admet-1476	418	6	25	25	NUM
admet-1476	418	7	(	(	PUNCT
admet-1476	418	8	1999	1999	NUM
admet-1476	418	9	)	)	PUNCT
admet-1476	418	10	47	47	NUM
admet-1476	418	11	-	-	SYM
admet-1476	418	12	50	50	NUM
admet-1476	418	13	.	.	PUNCT
admet-1476	419	1	pmid	pmid	NOUN
admet-1476	419	2	:	:	PUNCT
admet-1476	419	3	10440423	10440423	NUM
admet-1476	419	4	.	.	PUNCT
admet-1476	420	1	[	[	X
admet-1476	420	2	44	44	NUM
admet-1476	420	3	]	]	X
admet-1476	420	4	d.p	d.p	PROPN
admet-1476	420	5	.	.	PUNCT
admet-1476	420	6	reitberg	reitberg	PROPN
admet-1476	420	7	,	,	PUNCT
admet-1476	420	8	s.j	s.j	PROPN
admet-1476	420	9	.	.	PROPN
admet-1476	420	10	love	love	PROPN
admet-1476	420	11	,	,	PUNCT
admet-1476	420	12	g.t	g.t	PROPN
admet-1476	420	13	.	.	PROPN
admet-1476	420	14	quercia	quercia	PROPN
admet-1476	420	15	,	,	PUNCT
admet-1476	420	16	m.a	m.a	PROPN
admet-1476	420	17	.	.	PUNCT
admet-1476	420	18	zinny	zinny	PROPN
admet-1476	420	19	.	.	PUNCT
admet-1476	421	1	effect	effect	NOUN
admet-1476	421	2	of	of	ADP
admet-1476	421	3	food	food	NOUN
admet-1476	421	4	on	on	ADP
admet-1476	421	5	nifedipine	nifedipine	NOUN
admet-1476	421	6	pharmacokinetics	pharmacokinetic	NOUN
admet-1476	421	7	.	.	PUNCT
admet-1476	422	1	clinical	clinical	ADJ
admet-1476	422	2	pharmacology	pharmacology	NOUN
admet-1476	422	3	&	&	CCONJ
admet-1476	422	4	therapeutics	therapeutic	NOUN
admet-1476	422	5	42	42	NUM
admet-1476	422	6	(	(	PUNCT
admet-1476	422	7	1987	1987	NUM
admet-1476	422	8	)	)	PUNCT
admet-1476	422	9	72	72	NUM
admet-1476	422	10	-	-	SYM
admet-1476	422	11	75	75	NUM
admet-1476	422	12	.	.	PUNCT
admet-1476	423	1	https://doi.org/10.1038/clpt.1987.110	https://doi.org/10.1038/clpt.1987.110	NOUN
admet-1476	423	2	.	.	PUNCT
admet-1476	424	1	©	©	NOUN
admet-1476	424	2	2022	2022	NUM
admet-1476	424	3	by	by	ADP
admet-1476	424	4	the	the	DET
admet-1476	424	5	authors	author	NOUN
admet-1476	424	6	;	;	PUNCT
admet-1476	424	7	licensee	licensee	PROPN
admet-1476	424	8	iapc	iapc	PROPN
admet-1476	424	9	,	,	PUNCT
admet-1476	424	10	zagreb	zagreb	PROPN
admet-1476	424	11	,	,	PUNCT
admet-1476	424	12	croatia	croatia	PROPN
admet-1476	424	13	.	.	PUNCT
admet-1476	425	1	this	this	DET
admet-1476	425	2	article	article	NOUN
admet-1476	425	3	is	be	AUX
admet-1476	425	4	an	an	DET
admet-1476	425	5	open	open	ADJ
admet-1476	425	6	-	-	PUNCT
admet-1476	425	7	access	access	NOUN
admet-1476	425	8	article	article	NOUN
admet-1476	425	9	distributed	distribute	VERB
admet-1476	425	10	under	under	ADP
admet-1476	425	11	the	the	DET
admet-1476	425	12	terms	term	NOUN
admet-1476	425	13	and	and	CCONJ
admet-1476	425	14	conditions	condition	NOUN
admet-1476	425	15	of	of	ADP
admet-1476	425	16	the	the	DET
admet-1476	425	17	creative	creative	ADJ
admet-1476	425	18	commons	common	NOUN
admet-1476	425	19	attribution	attribution	NOUN
admet-1476	425	20	license	license	NOUN
admet-1476	425	21	(	(	PUNCT
admet-1476	425	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1476	425	23	)	)	PUNCT
admet-1476	425	24	https://doi.org/10.1002/(sici)1099-081x(199603)17:2%3c135::aid-bdd947%3e3.0.co;2-k	https://doi.org/10.1002/(sici)1099-081x(199603)17:2%3c135::aid-bdd947%3e3.0.co;2-k	PROPN
admet-1476	425	25	https://doi.org/10.1016/j.ijpharm.2013.04.003	https://doi.org/10.1016/j.ijpharm.2013.04.003	PROPN
admet-1476	425	26	https://doi.org/10.1016/j.ejps.2010.03.011	https://doi.org/10.1016/j.ejps.2010.03.011	PROPN
admet-1476	425	27	https://doi.org/10.1097/00002030-199003000-00008	https://doi.org/10.1097/00002030-199003000-00008	NOUN
admet-1476	425	28	https://doi.org/10.1097/00002030-199003000-00008	https://doi.org/10.1097/00002030-199003000-00008	PROPN
admet-1476	425	29	https://doi.org/10.1038/clpt.1987.110	https://doi.org/10.1038/clpt.1987.110	PROPN
admet-1476	425	30	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1476	425	31	)	)	PUNCT