id	sid	tid	token	lemma	pos
admet-1513	1	1	role	role	NOUN
admet-1513	1	2	of	of	ADP
admet-1513	1	3	in	in	ADP
admet-1513	1	4	vitro	vitro	X
admet-1513	1	5	two	two	NUM
admet-1513	1	6	-	-	PUNCT
admet-1513	1	7	dimensional	dimensional	ADJ
admet-1513	1	8	(	(	PUNCT
admet-1513	1	9	2d	2d	NOUN
admet-1513	1	10	)	)	PUNCT
admet-1513	1	11	and	and	CCONJ
admet-1513	1	12	three	three	NUM
admet-1513	1	13	-	-	PUNCT
admet-1513	1	14	dimensional	dimensional	ADJ
admet-1513	1	15	(	(	PUNCT
admet-1513	1	16	3d	3d	NOUN
admet-1513	1	17	)	)	PUNCT
admet-1513	1	18	cell	cell	NOUN
admet-1513	1	19	culture	culture	NOUN
admet-1513	1	20	systems	system	NOUN
admet-1513	1	21	for	for	ADP
admet-1513	1	22	adme	adme	NOUN
admet-1513	1	23	-	-	PUNCT
admet-1513	1	24	tox	tox	NOUN
admet-1513	1	25	screening	screening	NOUN
admet-1513	1	26	in	in	ADP
admet-1513	1	27	drug	drug	NOUN
admet-1513	1	28	discovery	discovery	NOUN
admet-1513	1	29	and	and	CCONJ
admet-1513	1	30	development	development	NOUN
admet-1513	1	31	:	:	PUNCT
admet-1513	1	32	a	a	DET
admet-1513	1	33	comprehensive	comprehensive	ADJ
admet-1513	1	34	review	review	NOUN
admet-1513	1	35	1	1	NUM
admet-1513	1	36	admet	admet	X
admet-1513	1	37	&	&	CCONJ
admet-1513	1	38	dmpk	dmpk	PROPN
admet-1513	1	39	11(1	11(1	NUM
admet-1513	1	40	)	)	PUNCT
admet-1513	1	41	(	(	PUNCT
admet-1513	1	42	2023	2023	NUM
admet-1513	1	43	)	)	PUNCT
admet-1513	1	44	1	1	NUM
admet-1513	1	45	-	-	SYM
admet-1513	1	46	32	32	NUM
admet-1513	1	47	;	;	PUNCT
admet-1513	1	48	doi	doi	NOUN
admet-1513	1	49	:	:	PUNCT
admet-1513	1	50	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	1	51	open	open	ADJ
admet-1513	1	52	access	access	NOUN
admet-1513	1	53	:	:	PUNCT
admet-1513	1	54	issn	issn	PROPN
admet-1513	1	55	:	:	PUNCT
admet-1513	1	56	1848	1848	NUM
admet-1513	1	57	-	-	SYM
admet-1513	1	58	7718	7718	NUM
admet-1513	1	59	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1513	1	60	review	review	NOUN
admet-1513	1	61	role	role	NOUN
admet-1513	1	62	of	of	ADP
admet-1513	1	63	in	in	ADP
admet-1513	1	64	vitro	vitro	X
admet-1513	1	65	two	two	NUM
admet-1513	1	66	-	-	PUNCT
admet-1513	1	67	dimensional	dimensional	ADJ
admet-1513	1	68	(	(	PUNCT
admet-1513	1	69	2d	2d	NOUN
admet-1513	1	70	)	)	PUNCT
admet-1513	1	71	and	and	CCONJ
admet-1513	1	72	three	three	NUM
admet-1513	1	73	-	-	PUNCT
admet-1513	1	74	dimensional	dimensional	ADJ
admet-1513	1	75	(	(	PUNCT
admet-1513	1	76	3d	3d	NOUN
admet-1513	1	77	)	)	PUNCT
admet-1513	1	78	cell	cell	NOUN
admet-1513	1	79	culture	culture	NOUN
admet-1513	1	80	systems	system	NOUN
admet-1513	1	81	for	for	ADP
admet-1513	1	82	adme	adme	NOUN
admet-1513	1	83	-	-	PUNCT
admet-1513	1	84	tox	tox	NOUN
admet-1513	1	85	screening	screening	NOUN
admet-1513	1	86	in	in	ADP
admet-1513	1	87	drug	drug	NOUN
admet-1513	1	88	discovery	discovery	NOUN
admet-1513	1	89	and	and	CCONJ
admet-1513	1	90	development	development	NOUN
admet-1513	1	91	:	:	PUNCT
admet-1513	1	92	a	a	DET
admet-1513	1	93	comprehensive	comprehensive	ADJ
admet-1513	1	94	review	review	NOUN
admet-1513	1	95	venkatesh	venkatesh	PROPN
admet-1513	1	96	chunduri	chunduri	PROPN
admet-1513	1	97	,	,	PUNCT
admet-1513	1	98	srinivas	srinivas	PROPN
admet-1513	1	99	maddi	maddi	PROPN
admet-1513	1	100	*	*	SYM
admet-1513	1	101	acubiosys	acubiosys	PROPN
admet-1513	1	102	private	private	ADJ
admet-1513	1	103	limited	limited	ADJ
admet-1513	1	104	,	,	PUNCT
admet-1513	1	105	plot	plot	NOUN
admet-1513	1	106	#	#	NOUN
admet-1513	1	107	d-14a	d-14a	NOUN
admet-1513	1	108	,	,	PUNCT
admet-1513	1	109	industrial	industrial	ADJ
admet-1513	1	110	area	area	NOUN
admet-1513	1	111	,	,	PUNCT
admet-1513	1	112	tssic	tssic	ADJ
admet-1513	1	113	-	-	PUNCT
admet-1513	1	114	iala	iala	NOUN
admet-1513	1	115	,	,	PUNCT
admet-1513	1	116	moula	moula	PROPN
admet-1513	1	117	ali	ali	PROPN
admet-1513	1	118	,	,	PUNCT
admet-1513	1	119	hyderabad	hyderabad	PROPN
admet-1513	1	120	,	,	PUNCT
admet-1513	1	121	telangana	telangana	PROPN
admet-1513	1	122	500040	500040	NUM
admet-1513	1	123	,	,	PUNCT
admet-1513	1	124	india	india	PROPN
admet-1513	1	125	*	*	PUNCT
admet-1513	1	126	corresponding	correspond	VERB
admet-1513	1	127	author	author	NOUN
admet-1513	1	128	:	:	PUNCT
admet-1513	1	129	e	e	NOUN
admet-1513	1	130	-	-	NOUN
admet-1513	1	131	mail	mail	NOUN
admet-1513	1	132	:	:	PUNCT
admet-1513	1	133	srinivasm@acubiosys.com	srinivasm@acubiosys.com	PROPN
admet-1513	1	134	;	;	PUNCT
admet-1513	1	135	tel	tel	PROPN
admet-1513	1	136	.	.	PUNCT
admet-1513	1	137	:	:	PUNCT
admet-1513	2	1	+91	+91	NOUN
admet-1513	2	2	-	-	PUNCT
admet-1513	2	3	9966142344	9966142344	NUM
admet-1513	2	4	.	.	PUNCT
admet-1513	3	1	received	receive	VERB
admet-1513	3	2	:	:	PUNCT
admet-1513	3	3	september	september	PROPN
admet-1513	3	4	10	10	NUM
admet-1513	3	5	,	,	PUNCT
admet-1513	3	6	2022	2022	NUM
admet-1513	3	7	;	;	PUNCT
admet-1513	3	8	revised	revise	VERB
admet-1513	3	9	:	:	PUNCT
admet-1513	3	10	october	october	PROPN
admet-1513	3	11	07	07	NUM
admet-1513	3	12	,	,	PUNCT
admet-1513	3	13	2022	2022	NUM
admet-1513	3	14	;	;	PUNCT
admet-1513	3	15	published	publish	VERB
admet-1513	3	16	:	:	PUNCT
admet-1513	3	17	october	october	PROPN
admet-1513	3	18	10	10	NUM
admet-1513	3	19	,	,	PUNCT
admet-1513	3	20	2022	2022	NUM
admet-1513	3	21	abstract	abstract	ADJ
admet-1513	3	22	drug	drug	NOUN
admet-1513	3	23	discovery	discovery	NOUN
admet-1513	3	24	and	and	CCONJ
admet-1513	3	25	development	development	NOUN
admet-1513	3	26	have	have	AUX
admet-1513	3	27	become	become	VERB
admet-1513	3	28	a	a	DET
admet-1513	3	29	very	very	ADV
admet-1513	3	30	time	time	NOUN
admet-1513	3	31	-	-	PUNCT
admet-1513	3	32	consuming	consume	VERB
admet-1513	3	33	and	and	CCONJ
admet-1513	3	34	expensive	expensive	ADJ
admet-1513	3	35	process	process	NOUN
admet-1513	3	36	.	.	PUNCT
admet-1513	4	1	preclinical	preclinical	ADJ
admet-1513	4	2	animal	animal	NOUN
admet-1513	4	3	models	model	NOUN
admet-1513	4	4	have	have	AUX
admet-1513	4	5	become	become	VERB
admet-1513	4	6	the	the	DET
admet-1513	4	7	gold	gold	ADJ
admet-1513	4	8	standard	standard	NOUN
admet-1513	4	9	for	for	ADP
admet-1513	4	10	studying	study	VERB
admet-1513	4	11	drug	drug	NOUN
admet-1513	4	12	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	4	13	and	and	CCONJ
admet-1513	4	14	toxicity	toxicity	NOUN
admet-1513	4	15	parameters	parameter	NOUN
admet-1513	4	16	.	.	PUNCT
admet-1513	5	1	however	however	ADV
admet-1513	5	2	,	,	PUNCT
admet-1513	5	3	the	the	DET
admet-1513	5	4	involvement	involvement	NOUN
admet-1513	5	5	of	of	ADP
admet-1513	5	6	a	a	DET
admet-1513	5	7	huge	huge	ADJ
admet-1513	5	8	number	number	NOUN
admet-1513	5	9	of	of	ADP
admet-1513	5	10	animal	animal	NOUN
admet-1513	5	11	subjects	subject	NOUN
admet-1513	5	12	and	and	CCONJ
admet-1513	5	13	inter	inter	ADJ
admet-1513	5	14	-	-	ADJ
admet-1513	5	15	species	species	ADJ
admet-1513	5	16	pathophysiological	pathophysiological	ADJ
admet-1513	5	17	variations	variation	NOUN
admet-1513	5	18	between	between	ADP
admet-1513	5	19	animals	animal	NOUN
admet-1513	5	20	and	and	CCONJ
admet-1513	5	21	humans	human	NOUN
admet-1513	5	22	has	have	AUX
admet-1513	5	23	provoked	provoke	VERB
admet-1513	5	24	a	a	DET
admet-1513	5	25	lot	lot	NOUN
admet-1513	5	26	of	of	ADP
admet-1513	5	27	debate	debate	NOUN
admet-1513	5	28	,	,	PUNCT
admet-1513	5	29	particularly	particularly	ADV
admet-1513	5	30	because	because	SCONJ
admet-1513	5	31	of	of	ADP
admet-1513	5	32	ethical	ethical	ADJ
admet-1513	5	33	concerns	concern	NOUN
admet-1513	5	34	.	.	PUNCT
admet-1513	6	1	although	although	SCONJ
admet-1513	6	2	many	many	ADJ
admet-1513	6	3	efforts	effort	NOUN
admet-1513	6	4	are	be	AUX
admet-1513	6	5	being	be	AUX
admet-1513	6	6	established	establish	VERB
admet-1513	6	7	by	by	ADP
admet-1513	6	8	biotech	biotech	ADJ
admet-1513	6	9	and	and	CCONJ
admet-1513	6	10	pharmaceutical	pharmaceutical	NOUN
admet-1513	6	11	companies	company	NOUN
admet-1513	6	12	for	for	ADP
admet-1513	6	13	screening	screen	VERB
admet-1513	6	14	new	new	ADJ
admet-1513	6	15	chemical	chemical	NOUN
admet-1513	6	16	entities	entity	NOUN
admet-1513	6	17	in	in	ADP
admet-1513	6	18	vitro	vitro	ADJ
admet-1513	6	19	before	before	ADP
admet-1513	6	20	preclinical	preclinical	ADJ
admet-1513	6	21	trials	trial	NOUN
admet-1513	6	22	,	,	PUNCT
admet-1513	6	23	failures	failure	NOUN
admet-1513	6	24	during	during	ADP
admet-1513	6	25	clinical	clinical	ADJ
admet-1513	6	26	trials	trial	NOUN
admet-1513	6	27	are	be	AUX
admet-1513	6	28	still	still	ADV
admet-1513	6	29	involved	involve	VERB
admet-1513	6	30	.	.	PUNCT
admet-1513	7	1	currently	currently	ADV
admet-1513	7	2	,	,	PUNCT
admet-1513	7	3	a	a	DET
admet-1513	7	4	large	large	ADJ
admet-1513	7	5	number	number	NOUN
admet-1513	7	6	of	of	ADP
admet-1513	7	7	twodimensional	twodimensional	ADJ
admet-1513	7	8	(	(	PUNCT
admet-1513	7	9	2d	2d	NOUN
admet-1513	7	10	)	)	PUNCT
admet-1513	7	11	in	in	ADP
admet-1513	7	12	vitro	vitro	X
admet-1513	7	13	assays	assay	NOUN
admet-1513	7	14	have	have	AUX
admet-1513	7	15	been	be	AUX
admet-1513	7	16	developed	develop	VERB
admet-1513	7	17	and	and	CCONJ
admet-1513	7	18	are	be	AUX
admet-1513	7	19	being	be	AUX
admet-1513	7	20	developed	develop	VERB
admet-1513	7	21	by	by	ADP
admet-1513	7	22	researchers	researcher	NOUN
admet-1513	7	23	for	for	ADP
admet-1513	7	24	the	the	DET
admet-1513	7	25	screening	screening	NOUN
admet-1513	7	26	of	of	ADP
admet-1513	7	27	compounds	compound	NOUN
admet-1513	7	28	.	.	PUNCT
admet-1513	8	1	although	although	SCONJ
admet-1513	8	2	these	these	DET
admet-1513	8	3	assays	assay	NOUN
admet-1513	8	4	are	be	AUX
admet-1513	8	5	helpful	helpful	ADJ
admet-1513	8	6	in	in	ADP
admet-1513	8	7	screening	screen	VERB
admet-1513	8	8	a	a	DET
admet-1513	8	9	huge	huge	ADJ
admet-1513	8	10	library	library	NOUN
admet-1513	8	11	of	of	ADP
admet-1513	8	12	compounds	compound	NOUN
admet-1513	8	13	and	and	CCONJ
admet-1513	8	14	have	have	AUX
admet-1513	8	15	shown	show	VERB
admet-1513	8	16	perception	perception	NOUN
admet-1513	8	17	,	,	PUNCT
admet-1513	8	18	there	there	PRON
admet-1513	8	19	is	be	VERB
admet-1513	8	20	a	a	DET
admet-1513	8	21	significant	significant	ADJ
admet-1513	8	22	lack	lack	NOUN
admet-1513	8	23	in	in	ADP
admet-1513	8	24	predicting	predict	VERB
admet-1513	8	25	human	human	ADJ
admet-1513	8	26	absorption	absorption	NOUN
admet-1513	8	27	,	,	PUNCT
admet-1513	8	28	distribution	distribution	NOUN
admet-1513	8	29	,	,	PUNCT
admet-1513	8	30	metabolism	metabolism	NOUN
admet-1513	8	31	,	,	PUNCT
admet-1513	8	32	excretion	excretion	NOUN
admet-1513	8	33	and	and	CCONJ
admet-1513	8	34	toxicology	toxicology	NOUN
admet-1513	8	35	(	(	PUNCT
admet-1513	8	36	adme	adme	NOUN
admet-1513	8	37	-	-	PUNCT
admet-1513	8	38	tox	tox	NOUN
admet-1513	8	39	)	)	PUNCT
admet-1513	8	40	.	.	PUNCT
admet-1513	9	1	as	as	ADP
admet-1513	9	2	a	a	DET
admet-1513	9	3	result	result	NOUN
admet-1513	9	4	,	,	PUNCT
admet-1513	9	5	these	these	DET
admet-1513	9	6	assays	assay	NOUN
admet-1513	9	7	can	can	AUX
admet-1513	9	8	not	not	PART
admet-1513	9	9	completely	completely	ADV
admet-1513	9	10	replace	replace	VERB
admet-1513	9	11	animal	animal	NOUN
admet-1513	9	12	models	model	NOUN
admet-1513	9	13	.	.	PUNCT
admet-1513	10	1	the	the	DET
admet-1513	10	2	recent	recent	ADJ
admet-1513	10	3	inventions	invention	NOUN
admet-1513	10	4	in	in	ADP
admet-1513	10	5	three	three	NUM
admet-1513	10	6	-	-	PUNCT
admet-1513	10	7	dimensional	dimensional	ADJ
admet-1513	10	8	(	(	PUNCT
admet-1513	10	9	3d	3d	NOUN
admet-1513	10	10	)	)	PUNCT
admet-1513	10	11	cell	cell	NOUN
admet-1513	10	12	culture	culture	NOUN
admet-1513	10	13	-	-	PUNCT
admet-1513	10	14	based	base	VERB
admet-1513	10	15	assays	assay	NOUN
admet-1513	10	16	like	like	ADP
admet-1513	10	17	organoids	organoid	NOUN
admet-1513	10	18	and	and	CCONJ
admet-1513	10	19	micro	micro	ADJ
admet-1513	10	20	-	-	ADJ
admet-1513	10	21	physiological	physiological	ADJ
admet-1513	10	22	systems	system	NOUN
admet-1513	10	23	have	have	AUX
admet-1513	10	24	shown	show	VERB
admet-1513	10	25	great	great	ADJ
admet-1513	10	26	potential	potential	ADJ
admet-1513	10	27	alternative	alternative	ADJ
admet-1513	10	28	tools	tool	NOUN
admet-1513	10	29	for	for	ADP
admet-1513	10	30	predicting	predict	VERB
admet-1513	10	31	the	the	DET
admet-1513	10	32	compound	compound	NOUN
admet-1513	10	33	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	10	34	and	and	CCONJ
admet-1513	10	35	pharmacodynamic	pharmacodynamic	ADJ
admet-1513	10	36	fate	fate	NOUN
admet-1513	10	37	in	in	ADP
admet-1513	10	38	humans	human	NOUN
admet-1513	10	39	.	.	PUNCT
admet-1513	11	1	in	in	ADP
admet-1513	11	2	this	this	DET
admet-1513	11	3	comprehensive	comprehensive	ADJ
admet-1513	11	4	review	review	NOUN
admet-1513	11	5	,	,	PUNCT
admet-1513	11	6	we	we	PRON
admet-1513	11	7	have	have	AUX
admet-1513	11	8	summarized	summarize	VERB
admet-1513	11	9	some	some	PRON
admet-1513	11	10	of	of	ADP
admet-1513	11	11	the	the	DET
admet-1513	11	12	most	most	ADV
admet-1513	11	13	commonly	commonly	ADV
admet-1513	11	14	used	use	VERB
admet-1513	11	15	2d	2d	NOUN
admet-1513	11	16	in	in	ADP
admet-1513	11	17	vitro	vitro	X
admet-1513	11	18	assays	assay	NOUN
admet-1513	11	19	and	and	CCONJ
admet-1513	11	20	emphasized	emphasize	VERB
admet-1513	11	21	the	the	DET
admet-1513	11	22	achievements	achievement	NOUN
admet-1513	11	23	in	in	ADP
admet-1513	11	24	next	next	ADJ
admet-1513	11	25	-	-	PUNCT
admet-1513	11	26	generation	generation	NOUN
admet-1513	11	27	3d	3d	NUM
admet-1513	11	28	cell	cell	NOUN
admet-1513	11	29	culture	culture	NOUN
admet-1513	11	30	-	-	PUNCT
admet-1513	11	31	based	base	VERB
admet-1513	11	32	systems	system	NOUN
admet-1513	11	33	for	for	ADP
admet-1513	11	34	predicting	predict	VERB
admet-1513	11	35	the	the	DET
admet-1513	11	36	compound	compound	NOUN
admet-1513	11	37	adme	adme	NOUN
admet-1513	11	38	-	-	PUNCT
admet-1513	11	39	tox	tox	NOUN
admet-1513	11	40	.	.	PUNCT
admet-1513	12	1	©	©	NOUN
admet-1513	12	2	2022	2022	NUM
admet-1513	12	3	by	by	ADP
admet-1513	12	4	the	the	DET
admet-1513	12	5	authors	author	NOUN
admet-1513	12	6	.	.	PUNCT
admet-1513	13	1	this	this	DET
admet-1513	13	2	article	article	NOUN
admet-1513	13	3	is	be	AUX
admet-1513	13	4	an	an	DET
admet-1513	13	5	open	open	ADJ
admet-1513	13	6	-	-	PUNCT
admet-1513	13	7	access	access	NOUN
admet-1513	13	8	article	article	NOUN
admet-1513	13	9	distributed	distribute	VERB
admet-1513	13	10	under	under	ADP
admet-1513	13	11	the	the	DET
admet-1513	13	12	terms	term	NOUN
admet-1513	13	13	and	and	CCONJ
admet-1513	13	14	conditions	condition	NOUN
admet-1513	13	15	of	of	ADP
admet-1513	13	16	the	the	DET
admet-1513	13	17	creative	creative	ADJ
admet-1513	13	18	commons	common	NOUN
admet-1513	13	19	attribution	attribution	NOUN
admet-1513	13	20	license	license	NOUN
admet-1513	13	21	(	(	PUNCT
admet-1513	13	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1513	13	23	)	)	PUNCT
admet-1513	13	24	.	.	PUNCT
admet-1513	14	1	keywords	keyword	VERB
admet-1513	14	2	2d	2d	PROPN
admet-1513	14	3	in	in	ADP
admet-1513	14	4	vitro	vitro	NOUN
admet-1513	14	5	;	;	PUNCT
admet-1513	14	6	3d	3d	NUM
admet-1513	14	7	in	in	ADP
admet-1513	14	8	vitro	vitro	X
admet-1513	14	9	;	;	PUNCT
admet-1513	14	10	adme	adme	NOUN
admet-1513	14	11	;	;	PUNCT
admet-1513	14	12	toxicology	toxicology	NOUN
admet-1513	14	13	;	;	PUNCT
admet-1513	14	14	organoids	organoid	NOUN
admet-1513	14	15	;	;	PUNCT
admet-1513	14	16	micro	micro	ADJ
admet-1513	14	17	-	-	ADJ
admet-1513	14	18	physiological	physiological	ADJ
admet-1513	14	19	systems	system	NOUN
admet-1513	14	20	introduction	introduction	NOUN
admet-1513	14	21	the	the	DET
admet-1513	14	22	current	current	ADJ
admet-1513	14	23	challenge	challenge	NOUN
admet-1513	14	24	in	in	ADP
admet-1513	14	25	drug	drug	NOUN
admet-1513	14	26	discovery	discovery	NOUN
admet-1513	14	27	programs	program	NOUN
admet-1513	14	28	for	for	ADP
admet-1513	14	29	the	the	DET
admet-1513	14	30	pharmaceutical	pharmaceutical	ADJ
admet-1513	14	31	industry	industry	NOUN
admet-1513	14	32	is	be	AUX
admet-1513	14	33	increasing	increase	VERB
admet-1513	14	34	patient	patient	ADJ
admet-1513	14	35	access	access	NOUN
admet-1513	14	36	to	to	ADP
admet-1513	14	37	novel	novel	ADJ
admet-1513	14	38	medications	medication	NOUN
admet-1513	14	39	while	while	SCONJ
admet-1513	14	40	reducing	reduce	VERB
admet-1513	14	41	attrition	attrition	NOUN
admet-1513	14	42	rates	rate	NOUN
admet-1513	14	43	.	.	PUNCT
admet-1513	15	1	in	in	ADP
admet-1513	15	2	recent	recent	ADJ
admet-1513	15	3	times	time	NOUN
admet-1513	15	4	,	,	PUNCT
admet-1513	15	5	despite	despite	SCONJ
admet-1513	15	6	many	many	ADJ
admet-1513	15	7	advances	advance	NOUN
admet-1513	15	8	in	in	ADP
admet-1513	15	9	disease	disease	NOUN
admet-1513	15	10	knowledge	knowledge	NOUN
admet-1513	15	11	and	and	CCONJ
admet-1513	15	12	the	the	DET
admet-1513	15	13	drug	drug	NOUN
admet-1513	15	14	discovery	discovery	NOUN
admet-1513	15	15	process	process	NOUN
admet-1513	15	16	,	,	PUNCT
admet-1513	15	17	the	the	DET
admet-1513	15	18	translation	translation	NOUN
admet-1513	15	19	of	of	ADP
admet-1513	15	20	these	these	DET
admet-1513	15	21	benefits	benefit	NOUN
admet-1513	15	22	into	into	ADP
admet-1513	15	23	therapeutic	therapeutic	ADJ
admet-1513	15	24	breakthroughs	breakthrough	NOUN
admet-1513	15	25	has	have	AUX
admet-1513	15	26	been	be	AUX
admet-1513	15	27	far	far	ADV
admet-1513	15	28	slower	slow	ADJ
admet-1513	15	29	than	than	SCONJ
admet-1513	15	30	anticipated	anticipate	VERB
admet-1513	15	31	[	[	X
admet-1513	15	32	1	1	NUM
admet-1513	15	33	]	]	PUNCT
admet-1513	15	34	.	.	PUNCT
admet-1513	16	1	the	the	DET
admet-1513	16	2	major	major	ADJ
admet-1513	16	3	challenges	challenge	VERB
admet-1513	16	4	a	a	DET
admet-1513	16	5	pharmaceutical	pharmaceutical	NOUN
admet-1513	16	6	industry	industry	NOUN
admet-1513	16	7	faces	face	VERB
admet-1513	16	8	during	during	ADP
admet-1513	16	9	the	the	DET
admet-1513	16	10	drug	drug	NOUN
admet-1513	16	11	discovery	discovery	NOUN
admet-1513	16	12	process	process	NOUN
admet-1513	16	13	include	include	VERB
admet-1513	16	14	a	a	DET
admet-1513	16	15	high	high	ADJ
admet-1513	16	16	churning	churning	ADJ
admet-1513	16	17	rate	rate	NOUN
admet-1513	16	18	,	,	PUNCT
admet-1513	16	19	duration	duration	NOUN
admet-1513	16	20	of	of	ADP
admet-1513	16	21	research	research	NOUN
admet-1513	16	22	,	,	PUNCT
admet-1513	16	23	and	and	CCONJ
admet-1513	16	24	changing	change	VERB
admet-1513	16	25	regulatory	regulatory	ADJ
admet-1513	16	26	considerations	consideration	NOUN
admet-1513	16	27	contributing	contribute	VERB
admet-1513	16	28	to	to	ADP
admet-1513	16	29	higher	high	ADJ
admet-1513	16	30	costs	cost	NOUN
admet-1513	16	31	[	[	X
admet-1513	16	32	2	2	NUM
admet-1513	16	33	]	]	PUNCT
admet-1513	16	34	.	.	PUNCT
admet-1513	17	1	for	for	ADP
admet-1513	17	2	a	a	DET
admet-1513	17	3	single	single	ADJ
admet-1513	17	4	drug	drug	NOUN
admet-1513	17	5	,	,	PUNCT
admet-1513	17	6	getting	get	VERB
admet-1513	17	7	fda	fda	PROPN
admet-1513	17	8	approval	approval	NOUN
admet-1513	17	9	requires	require	VERB
admet-1513	17	10	an	an	DET
admet-1513	17	11	investment	investment	NOUN
admet-1513	17	12	of	of	ADP
admet-1513	17	13	us$1	us$1	PROPN
admet-1513	17	14	-	-	SYM
admet-1513	17	15	2	2	NUM
admet-1513	17	16	billion	billion	NUM
admet-1513	17	17	and	and	CCONJ
admet-1513	17	18	an	an	DET
admet-1513	17	19	average	average	NOUN
admet-1513	17	20	of	of	ADP
admet-1513	17	21	10	10	NUM
admet-1513	17	22	-	-	SYM
admet-1513	17	23	15	15	NUM
admet-1513	17	24	years	year	NOUN
admet-1513	17	25	of	of	ADP
admet-1513	17	26	research	research	NOUN
admet-1513	17	27	and	and	CCONJ
admet-1513	17	28	development	development	NOUN
admet-1513	17	29	[	[	X
admet-1513	17	30	3	3	NUM
admet-1513	17	31	]	]	PUNCT
admet-1513	17	32	.	.	PUNCT
admet-1513	18	1	moreover	moreover	ADV
admet-1513	18	2	,	,	PUNCT
admet-1513	18	3	only	only	ADV
admet-1513	18	4	one	one	NUM
admet-1513	18	5	in	in	ADP
admet-1513	18	6	every	every	DET
admet-1513	18	7	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	18	8	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1513	18	9	mailto:srinivasm@acubiosys.com	mailto:srinivasm@acubiosys.com	PROPN
admet-1513	18	10	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1513	18	11	venkatesh	venkatesh	PROPN
admet-1513	18	12	chunduri	chunduri	PROPN
admet-1513	18	13	and	and	CCONJ
admet-1513	18	14	srinivas	srinivas	PROPN
admet-1513	18	15	maddi	maddi	PROPN
admet-1513	18	16	admet	admet	PROPN
admet-1513	18	17	&	&	CCONJ
admet-1513	18	18	dmpk	dmpk	PROPN
admet-1513	18	19	11(1	11(1	NUM
admet-1513	18	20	)	)	PUNCT
admet-1513	18	21	(	(	PUNCT
admet-1513	18	22	2023	2023	NUM
admet-1513	18	23	)	)	PUNCT
admet-1513	18	24	1	1	NUM
admet-1513	18	25	-	-	SYM
admet-1513	18	26	32	32	NUM
admet-1513	18	27	2	2	NUM
admet-1513	18	28	5000	5000	NUM
admet-1513	18	29	-	-	SYM
admet-1513	18	30	10000	10000	NUM
admet-1513	18	31	candidates	candidate	NOUN
admet-1513	18	32	receives	receive	VERB
admet-1513	18	33	fda	fda	PROPN
admet-1513	18	34	approval	approval	NOUN
admet-1513	18	35	.	.	PUNCT
admet-1513	19	1	thus	thus	ADV
admet-1513	19	2	,	,	PUNCT
admet-1513	19	3	efforts	effort	NOUN
admet-1513	19	4	have	have	VERB
admet-1513	19	5	to	to	PART
admet-1513	19	6	be	be	AUX
admet-1513	19	7	taken	take	VERB
admet-1513	19	8	for	for	ADP
admet-1513	19	9	alternate	alternate	ADJ
admet-1513	19	10	drug	drug	NOUN
admet-1513	19	11	discovery	discovery	NOUN
admet-1513	19	12	and	and	CCONJ
admet-1513	19	13	development	development	NOUN
admet-1513	19	14	processes	process	NOUN
admet-1513	19	15	[	[	X
admet-1513	19	16	4	4	NUM
admet-1513	19	17	]	]	PUNCT
admet-1513	19	18	.	.	PUNCT
admet-1513	20	1	furthermore	furthermore	ADV
admet-1513	20	2	,	,	PUNCT
admet-1513	20	3	these	these	DET
admet-1513	20	4	drugs	drug	NOUN
admet-1513	20	5	can	can	AUX
admet-1513	20	6	be	be	AUX
admet-1513	20	7	expensive	expensive	ADJ
admet-1513	20	8	and	and	CCONJ
admet-1513	20	9	linked	link	VERB
admet-1513	20	10	with	with	ADP
admet-1513	20	11	various	various	ADJ
admet-1513	20	12	side	side	NOUN
admet-1513	20	13	effects	effect	NOUN
admet-1513	20	14	.	.	PUNCT
admet-1513	21	1	the	the	DET
admet-1513	21	2	process	process	NOUN
admet-1513	21	3	of	of	ADP
admet-1513	21	4	drug	drug	NOUN
admet-1513	21	5	discovery	discovery	NOUN
admet-1513	21	6	includes	include	VERB
admet-1513	21	7	three	three	NUM
admet-1513	21	8	steps	step	NOUN
admet-1513	21	9	:	:	PUNCT
admet-1513	21	10	1	1	X
admet-1513	21	11	.	.	X
admet-1513	21	12	identification	identification	NOUN
admet-1513	21	13	and	and	CCONJ
admet-1513	21	14	synthesis	synthesis	NOUN
admet-1513	21	15	of	of	ADP
admet-1513	21	16	a	a	DET
admet-1513	21	17	new	new	ADJ
admet-1513	21	18	chemical	chemical	NOUN
admet-1513	21	19	entity	entity	NOUN
admet-1513	21	20	;	;	PUNCT
admet-1513	21	21	2	2	X
admet-1513	21	22	.	.	NOUN
admet-1513	21	23	preclinical	preclinical	ADJ
admet-1513	21	24	trials	trial	NOUN
admet-1513	21	25	,	,	PUNCT
admet-1513	21	26	which	which	PRON
admet-1513	21	27	include	include	VERB
admet-1513	21	28	celland	celland	NOUN
admet-1513	21	29	animal	animal	NOUN
admet-1513	21	30	-	-	PUNCT
admet-1513	21	31	based	base	VERB
admet-1513	21	32	efficacy	efficacy	NOUN
admet-1513	21	33	,	,	PUNCT
admet-1513	21	34	toxicity	toxicity	NOUN
admet-1513	21	35	,	,	PUNCT
admet-1513	21	36	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	21	37	and	and	CCONJ
admet-1513	21	38	pharmacodynamic	pharmacodynamic	ADJ
admet-1513	21	39	profiles	profile	NOUN
admet-1513	21	40	and	and	CCONJ
admet-1513	21	41	3	3	NUM
admet-1513	21	42	.	.	NOUN
admet-1513	21	43	clinical	clinical	ADJ
admet-1513	21	44	trials	trial	NOUN
admet-1513	21	45	.	.	PUNCT
admet-1513	22	1	the	the	DET
admet-1513	22	2	major	major	ADJ
admet-1513	22	3	cause	cause	NOUN
admet-1513	22	4	for	for	ADP
admet-1513	22	5	the	the	DET
admet-1513	22	6	candidate	candidate	NOUN
admet-1513	22	7	drug	drug	NOUN
admet-1513	22	8	failures	failure	NOUN
admet-1513	22	9	is	be	AUX
admet-1513	22	10	poor	poor	ADJ
admet-1513	22	11	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	22	12	and	and	CCONJ
admet-1513	22	13	pharmacodynamic	pharmacodynamic	ADJ
admet-1513	22	14	profiles	profile	NOUN
admet-1513	22	15	in	in	ADP
admet-1513	22	16	absorption	absorption	NOUN
admet-1513	22	17	,	,	PUNCT
admet-1513	22	18	distribution	distribution	NOUN
admet-1513	22	19	,	,	PUNCT
admet-1513	22	20	metabolism	metabolism	NOUN
admet-1513	22	21	,	,	PUNCT
admet-1513	22	22	excretion	excretion	NOUN
admet-1513	22	23	(	(	PUNCT
admet-1513	22	24	adme	adme	NOUN
admet-1513	22	25	)	)	PUNCT
admet-1513	22	26	and	and	CCONJ
admet-1513	22	27	toxicological	toxicological	ADJ
admet-1513	22	28	(	(	PUNCT
admet-1513	22	29	tox	tox	NOUN
admet-1513	22	30	)	)	PUNCT
admet-1513	22	31	studies	study	NOUN
admet-1513	22	32	[	[	X
admet-1513	22	33	5	5	NUM
admet-1513	22	34	]	]	PUNCT
admet-1513	22	35	.	.	PUNCT
admet-1513	23	1	thus	thus	ADV
admet-1513	23	2	,	,	PUNCT
admet-1513	23	3	the	the	DET
admet-1513	23	4	evaluation	evaluation	NOUN
admet-1513	23	5	of	of	ADP
admet-1513	23	6	adme	adme	NOUN
admet-1513	23	7	-	-	PUNCT
admet-1513	23	8	tox	tox	NOUN
admet-1513	23	9	mechanisms	mechanism	NOUN
admet-1513	23	10	has	have	AUX
admet-1513	23	11	become	become	VERB
admet-1513	23	12	a	a	DET
admet-1513	23	13	fundamental	fundamental	ADJ
admet-1513	23	14	step	step	NOUN
admet-1513	23	15	in	in	ADP
admet-1513	23	16	the	the	DET
admet-1513	23	17	drug	drug	NOUN
admet-1513	23	18	discovery	discovery	NOUN
admet-1513	23	19	process	process	NOUN
admet-1513	23	20	and	and	CCONJ
admet-1513	23	21	selection	selection	NOUN
admet-1513	23	22	of	of	ADP
admet-1513	23	23	new	new	ADJ
admet-1513	23	24	drug	drug	NOUN
admet-1513	23	25	candidates	candidate	NOUN
admet-1513	23	26	.	.	PUNCT
admet-1513	24	1	presently	presently	ADV
admet-1513	24	2	,	,	PUNCT
admet-1513	24	3	the	the	DET
admet-1513	24	4	best	good	ADJ
admet-1513	24	5	way	way	NOUN
admet-1513	24	6	to	to	PART
admet-1513	24	7	study	study	VERB
admet-1513	24	8	the	the	DET
admet-1513	24	9	adme	adme	NOUN
admet-1513	24	10	-	-	PUNCT
admet-1513	24	11	tox	tox	NOUN
admet-1513	24	12	processes	process	NOUN
admet-1513	24	13	is	be	AUX
admet-1513	24	14	through	through	ADP
admet-1513	24	15	in	in	ADP
admet-1513	24	16	vitro	vitro	X
admet-1513	24	17	and	and	CCONJ
admet-1513	24	18	in	in	ADP
admet-1513	24	19	vivo	vivo	NOUN
admet-1513	24	20	animal	animal	NOUN
admet-1513	24	21	models	model	NOUN
admet-1513	24	22	[	[	X
admet-1513	24	23	6	6	NUM
admet-1513	24	24	]	]	PUNCT
admet-1513	24	25	.	.	PUNCT
admet-1513	25	1	however	however	ADV
admet-1513	25	2	,	,	PUNCT
admet-1513	25	3	because	because	SCONJ
admet-1513	25	4	of	of	ADP
admet-1513	25	5	inter	inter	ADJ
admet-1513	25	6	-	-	ADJ
admet-1513	25	7	species	species	ADJ
admet-1513	25	8	variations	variation	NOUN
admet-1513	25	9	,	,	PUNCT
admet-1513	25	10	preclinical	preclinical	ADJ
admet-1513	25	11	variations	variation	NOUN
admet-1513	25	12	in	in	ADP
admet-1513	25	13	toxicology	toxicology	NOUN
admet-1513	25	14	findings	finding	NOUN
admet-1513	25	15	between	between	ADP
admet-1513	25	16	small	small	ADJ
admet-1513	25	17	(	(	PUNCT
admet-1513	25	18	rodents	rodent	NOUN
admet-1513	25	19	)	)	PUNCT
admet-1513	25	20	and	and	CCONJ
admet-1513	25	21	large	large	ADJ
admet-1513	25	22	(	(	PUNCT
admet-1513	25	23	dogs	dog	NOUN
admet-1513	25	24	/	/	SYM
admet-1513	25	25	monkeys	monkey	NOUN
admet-1513	25	26	)	)	PUNCT
admet-1513	25	27	ca	can	AUX
admet-1513	25	28	n’t	not	PART
admet-1513	25	29	replicate	replicate	VERB
admet-1513	25	30	the	the	DET
admet-1513	25	31	exact	exact	ADJ
admet-1513	25	32	mechanism	mechanism	NOUN
admet-1513	25	33	of	of	ADP
admet-1513	25	34	drug	drug	NOUN
admet-1513	25	35	transport	transport	NOUN
admet-1513	25	36	and	and	CCONJ
admet-1513	25	37	metabolism	metabolism	NOUN
admet-1513	25	38	as	as	ADP
admet-1513	25	39	that	that	PRON
admet-1513	25	40	of	of	ADP
admet-1513	25	41	humans	human	NOUN
admet-1513	25	42	,	,	PUNCT
admet-1513	25	43	as	as	SCONJ
admet-1513	25	44	they	they	PRON
admet-1513	25	45	have	have	VERB
admet-1513	25	46	a	a	DET
admet-1513	25	47	more	more	ADV
admet-1513	25	48	complex	complex	ADJ
admet-1513	25	49	mechanism	mechanism	NOUN
admet-1513	25	50	of	of	ADP
admet-1513	25	51	cell	cell	NOUN
admet-1513	25	52	-	-	PUNCT
admet-1513	25	53	to	to	ADP
admet-1513	25	54	-	-	PUNCT
admet-1513	25	55	cell	cell	NOUN
admet-1513	25	56	barrier	barrier	NOUN
admet-1513	25	57	and	and	CCONJ
admet-1513	25	58	enzyme	enzyme	NOUN
admet-1513	25	59	kinetics	kinetic	NOUN
admet-1513	26	1	[	[	X
admet-1513	26	2	7	7	NUM
admet-1513	26	3	-	-	SYM
admet-1513	26	4	9	9	NUM
admet-1513	26	5	]	]	PUNCT
admet-1513	26	6	.	.	PUNCT
admet-1513	27	1	while	while	SCONJ
admet-1513	27	2	animal	animal	NOUN
admet-1513	27	3	models	model	NOUN
admet-1513	27	4	remain	remain	VERB
admet-1513	27	5	a	a	DET
admet-1513	27	6	requisite	requisite	ADJ
admet-1513	27	7	tool	tool	NOUN
admet-1513	27	8	in	in	ADP
admet-1513	27	9	adme	adme	NOUN
admet-1513	27	10	-	-	PUNCT
admet-1513	27	11	tox	tox	NOUN
admet-1513	27	12	studies	study	NOUN
admet-1513	27	13	,	,	PUNCT
admet-1513	27	14	non	non	ADJ
admet-1513	27	15	-	-	ADJ
admet-1513	27	16	animal	animal	ADJ
admet-1513	27	17	models	model	NOUN
admet-1513	27	18	are	be	AUX
admet-1513	27	19	a	a	DET
admet-1513	27	20	prerequisite	prerequisite	NOUN
admet-1513	27	21	for	for	ADP
admet-1513	27	22	the	the	DET
admet-1513	27	23	transition	transition	NOUN
admet-1513	27	24	towards	towards	ADP
admet-1513	27	25	animal	animal	NOUN
admet-1513	27	26	-	-	PUNCT
admet-1513	27	27	free	free	ADJ
admet-1513	27	28	qualification	qualification	NOUN
admet-1513	27	29	of	of	ADP
admet-1513	27	30	new	new	ADJ
admet-1513	27	31	compounds	compound	NOUN
admet-1513	27	32	[	[	X
admet-1513	27	33	10	10	NUM
admet-1513	27	34	]	]	PUNCT
admet-1513	27	35	.	.	PUNCT
admet-1513	28	1	in	in	ADP
admet-1513	28	2	vitro	vitro	X
admet-1513	28	3	models	model	NOUN
admet-1513	28	4	and	and	CCONJ
admet-1513	28	5	cell	cell	NOUN
admet-1513	28	6	-	-	PUNCT
admet-1513	28	7	based	base	VERB
admet-1513	28	8	assays	assay	NOUN
admet-1513	28	9	have	have	AUX
admet-1513	28	10	served	serve	VERB
admet-1513	28	11	as	as	ADP
admet-1513	28	12	a	a	DET
admet-1513	28	13	basis	basis	NOUN
admet-1513	28	14	for	for	ADP
admet-1513	28	15	assessing	assess	VERB
admet-1513	28	16	the	the	DET
admet-1513	28	17	efficacy	efficacy	NOUN
admet-1513	28	18	and	and	CCONJ
admet-1513	28	19	risks	risk	NOUN
admet-1513	28	20	of	of	ADP
admet-1513	28	21	investigational	investigational	ADJ
admet-1513	28	22	novel	novel	ADJ
admet-1513	28	23	drug	drug	NOUN
admet-1513	28	24	candidates	candidate	NOUN
admet-1513	28	25	in	in	ADP
admet-1513	28	26	humans	human	NOUN
admet-1513	28	27	.	.	PUNCT
admet-1513	29	1	two	two	NUM
admet-1513	29	2	-	-	PUNCT
admet-1513	29	3	dimensional	dimensional	ADJ
admet-1513	29	4	(	(	PUNCT
admet-1513	29	5	2d	2d	NOUN
admet-1513	29	6	)	)	PUNCT
admet-1513	29	7	in	in	ADP
admet-1513	29	8	vitro	vitro	X
admet-1513	29	9	cell	cell	NOUN
admet-1513	29	10	culture	culture	NOUN
admet-1513	29	11	systems	system	NOUN
admet-1513	29	12	use	use	VERB
admet-1513	29	13	cells	cell	NOUN
admet-1513	29	14	obtained	obtain	VERB
admet-1513	29	15	from	from	ADP
admet-1513	29	16	human	human	ADJ
admet-1513	29	17	tissues	tissue	NOUN
admet-1513	29	18	to	to	PART
admet-1513	29	19	mimic	mimic	VERB
admet-1513	29	20	physiological	physiological	ADJ
admet-1513	29	21	and	and	CCONJ
admet-1513	29	22	metabolic	metabolic	NOUN
admet-1513	29	23	functionality	functionality	NOUN
admet-1513	29	24	.	.	PUNCT
admet-1513	30	1	in	in	ADP
admet-1513	30	2	vitro	vitro	X
admet-1513	30	3	cell	cell	NOUN
admet-1513	30	4	models	model	NOUN
admet-1513	30	5	were	be	AUX
admet-1513	30	6	designed	design	VERB
admet-1513	30	7	to	to	PART
admet-1513	30	8	simplify	simplify	VERB
admet-1513	30	9	the	the	DET
admet-1513	30	10	methodology	methodology	NOUN
admet-1513	30	11	of	of	ADP
admet-1513	30	12	the	the	DET
admet-1513	30	13	study	study	NOUN
admet-1513	30	14	of	of	ADP
admet-1513	30	15	compounds	compound	NOUN
admet-1513	30	16	that	that	PRON
admet-1513	30	17	are	be	AUX
admet-1513	30	18	cell	cell	NOUN
admet-1513	30	19	or	or	CCONJ
admet-1513	30	20	organ	organ	NOUN
admet-1513	30	21	-	-	PUNCT
admet-1513	30	22	specific	specific	NOUN
admet-1513	30	23	.	.	PUNCT
admet-1513	31	1	these	these	DET
admet-1513	31	2	models	model	NOUN
admet-1513	31	3	are	be	AUX
admet-1513	31	4	relatively	relatively	ADV
admet-1513	31	5	rapid	rapid	ADJ
admet-1513	31	6	and	and	CCONJ
admet-1513	31	7	cost	cost	NOUN
admet-1513	31	8	-	-	PUNCT
admet-1513	31	9	effective	effective	ADJ
admet-1513	31	10	and	and	CCONJ
admet-1513	31	11	further	further	ADJ
admet-1513	31	12	help	help	NOUN
admet-1513	31	13	in	in	ADP
admet-1513	31	14	indicating	indicate	VERB
admet-1513	31	15	the	the	DET
admet-1513	31	16	adme	adme	NOUN
admet-1513	31	17	fate	fate	NOUN
admet-1513	31	18	of	of	ADP
admet-1513	31	19	the	the	DET
admet-1513	31	20	compounds	compound	NOUN
admet-1513	31	21	[	[	X
admet-1513	31	22	11	11	NUM
admet-1513	31	23	]	]	PUNCT
admet-1513	31	24	.	.	PUNCT
admet-1513	32	1	however	however	ADV
admet-1513	32	2	,	,	PUNCT
admet-1513	32	3	the	the	DET
admet-1513	32	4	major	major	ADJ
admet-1513	32	5	drawback	drawback	NOUN
admet-1513	32	6	of	of	ADP
admet-1513	32	7	using	use	VERB
admet-1513	32	8	2d	2d	NUM
admet-1513	32	9	cultures	culture	NOUN
admet-1513	32	10	is	be	AUX
admet-1513	32	11	that	that	SCONJ
admet-1513	32	12	they	they	PRON
admet-1513	32	13	ca	can	AUX
admet-1513	32	14	n’t	not	PART
admet-1513	32	15	accurately	accurately	ADV
admet-1513	32	16	illustrate	illustrate	VERB
admet-1513	32	17	and	and	CCONJ
admet-1513	32	18	mimic	mimic	VERB
admet-1513	32	19	the	the	DET
admet-1513	32	20	complex	complex	ADJ
admet-1513	32	21	environment	environment	NOUN
admet-1513	32	22	compared	compare	VERB
admet-1513	32	23	to	to	ADP
admet-1513	32	24	in	in	ADP
admet-1513	32	25	vivo	vivo	NOUN
admet-1513	32	26	,	,	PUNCT
admet-1513	32	27	as	as	SCONJ
admet-1513	32	28	their	their	PRON
admet-1513	32	29	cellular	cellular	ADJ
admet-1513	32	30	organizations	organization	NOUN
admet-1513	32	31	reflect	reflect	VERB
admet-1513	32	32	their	their	PRON
admet-1513	32	33	behaviour	behaviour	NOUN
admet-1513	32	34	during	during	ADP
admet-1513	32	35	culturing	culture	VERB
admet-1513	32	36	[	[	X
admet-1513	32	37	12	12	NUM
admet-1513	32	38	]	]	PUNCT
admet-1513	32	39	.	.	PUNCT
admet-1513	33	1	to	to	PART
admet-1513	33	2	overcome	overcome	VERB
admet-1513	33	3	this	this	PRON
admet-1513	33	4	,	,	PUNCT
admet-1513	33	5	novel	novel	ADJ
admet-1513	33	6	preclinical	preclinical	ADJ
admet-1513	33	7	or	or	CCONJ
admet-1513	33	8	para	para	ADJ
admet-1513	33	9	-	-	PUNCT
admet-1513	33	10	clinical	clinical	ADJ
admet-1513	33	11	techniques	technique	NOUN
admet-1513	33	12	must	must	AUX
admet-1513	33	13	be	be	AUX
admet-1513	33	14	developed	develop	VERB
admet-1513	33	15	to	to	PART
admet-1513	33	16	compensate	compensate	VERB
admet-1513	33	17	for	for	ADP
admet-1513	33	18	and	and	CCONJ
admet-1513	33	19	elevate	elevate	VERB
admet-1513	33	20	the	the	DET
admet-1513	33	21	use	use	NOUN
admet-1513	33	22	of	of	ADP
admet-1513	33	23	better	well	ADJ
admet-1513	33	24	celland	celland	NOUN
admet-1513	33	25	organ	organ	NOUN
admet-1513	33	26	-	-	PUNCT
admet-1513	33	27	based	base	VERB
admet-1513	33	28	assays	assay	NOUN
admet-1513	33	29	for	for	ADP
admet-1513	33	30	a	a	DET
admet-1513	33	31	more	more	ADV
admet-1513	33	32	precise	precise	ADJ
admet-1513	33	33	representation	representation	NOUN
admet-1513	33	34	of	of	ADP
admet-1513	33	35	human	human	ADJ
admet-1513	33	36	response	response	NOUN
admet-1513	33	37	to	to	ADP
admet-1513	33	38	drug	drug	NOUN
admet-1513	33	39	candidates	candidate	NOUN
admet-1513	33	40	.	.	PUNCT
admet-1513	34	1	recently	recently	ADV
admet-1513	34	2	,	,	PUNCT
admet-1513	34	3	three	three	NUM
admet-1513	34	4	-	-	PUNCT
admet-1513	34	5	dimensional	dimensional	ADJ
admet-1513	34	6	(	(	PUNCT
admet-1513	34	7	3d	3d	NOUN
admet-1513	34	8	)	)	PUNCT
admet-1513	34	9	cell	cell	NOUN
admet-1513	34	10	cultures	culture	NOUN
admet-1513	34	11	emerged	emerge	VERB
admet-1513	34	12	as	as	ADP
admet-1513	34	13	a	a	DET
admet-1513	34	14	promising	promising	ADJ
admet-1513	34	15	tool	tool	NOUN
admet-1513	34	16	for	for	ADP
admet-1513	34	17	assessing	assess	VERB
admet-1513	34	18	drug	drug	NOUN
admet-1513	34	19	absorption	absorption	NOUN
admet-1513	34	20	,	,	PUNCT
admet-1513	34	21	drug	drug	NOUN
admet-1513	34	22	disposition	disposition	NOUN
admet-1513	34	23	and	and	CCONJ
admet-1513	34	24	pharmacokinetics	pharmacokinetic	NOUN
admet-1513	34	25	(	(	PUNCT
admet-1513	34	26	pks	pks	NOUN
admet-1513	34	27	)	)	PUNCT
admet-1513	34	28	,	,	PUNCT
admet-1513	34	29	which	which	PRON
admet-1513	34	30	influence	influence	VERB
admet-1513	34	31	drug	drug	NOUN
admet-1513	34	32	safety	safety	NOUN
admet-1513	34	33	and	and	CCONJ
admet-1513	34	34	efficacy	efficacy	NOUN
admet-1513	34	35	at	at	ADP
admet-1513	34	36	an	an	DET
admet-1513	34	37	early	early	ADJ
admet-1513	34	38	stage	stage	NOUN
admet-1513	34	39	in	in	ADP
admet-1513	34	40	drug	drug	NOUN
admet-1513	34	41	development	development	NOUN
admet-1513	34	42	.	.	PUNCT
admet-1513	35	1	they	they	PRON
admet-1513	35	2	have	have	VERB
admet-1513	35	3	better	well	ADJ
admet-1513	35	4	recreation	recreation	NOUN
admet-1513	35	5	of	of	ADP
admet-1513	35	6	tissue	tissue	NOUN
admet-1513	35	7	functionalities	functionality	NOUN
admet-1513	35	8	and	and	CCONJ
admet-1513	35	9	provide	provide	VERB
admet-1513	35	10	more	more	ADJ
admet-1513	35	11	physiological	physiological	ADJ
admet-1513	35	12	relevant	relevant	ADJ
admet-1513	35	13	niches	niche	NOUN
admet-1513	35	14	than	than	ADP
admet-1513	35	15	2d	2d	NUM
admet-1513	35	16	cultures	culture	NOUN
admet-1513	35	17	,	,	PUNCT
admet-1513	35	18	despite	despite	SCONJ
admet-1513	35	19	this	this	PRON
admet-1513	35	20	,	,	PUNCT
admet-1513	35	21	they	they	PRON
admet-1513	35	22	continue	continue	VERB
admet-1513	35	23	to	to	PART
admet-1513	35	24	have	have	VERB
admet-1513	35	25	an	an	DET
admet-1513	35	26	advantage	advantage	NOUN
admet-1513	35	27	over	over	ADP
admet-1513	35	28	animal	animal	NOUN
admet-1513	35	29	models	model	NOUN
admet-1513	35	30	.	.	PUNCT
admet-1513	36	1	presently	presently	ADV
admet-1513	36	2	,	,	PUNCT
admet-1513	36	3	there	there	PRON
admet-1513	36	4	are	be	VERB
admet-1513	36	5	many	many	ADJ
admet-1513	36	6	different	different	ADJ
admet-1513	36	7	types	type	NOUN
admet-1513	36	8	of	of	ADP
admet-1513	36	9	3d	3d	PROPN
admet-1513	36	10	cultures	culture	NOUN
admet-1513	36	11	viz	viz	PROPN
admet-1513	36	12	.	.	PUNCT
admet-1513	37	1	spheroids	spheroid	NOUN
admet-1513	37	2	,	,	PUNCT
admet-1513	37	3	organoids	organoid	NOUN
admet-1513	37	4	,	,	PUNCT
admet-1513	37	5	tumoroids	tumoroid	NOUN
admet-1513	37	6	,	,	PUNCT
admet-1513	37	7	3d	3d	NOUN
admet-1513	37	8	models	model	NOUN
admet-1513	37	9	equipped	equip	VERB
admet-1513	37	10	with	with	ADP
admet-1513	37	11	microfluid	microfluid	VERB
admet-1513	37	12	flow	flow	NOUN
admet-1513	37	13	controls	control	NOUN
admet-1513	37	14	or	or	CCONJ
admet-1513	37	15	micro	micro	ADJ
admet-1513	37	16	physiological	physiological	ADJ
admet-1513	37	17	systems	system	NOUN
admet-1513	37	18	(	(	PUNCT
admet-1513	37	19	mps	mps	PROPN
admet-1513	37	20	)	)	PUNCT
admet-1513	37	21	and	and	CCONJ
admet-1513	37	22	hybrid	hybrid	ADJ
admet-1513	37	23	3d	3d	PROPN
admet-1513	37	24	systems	system	NOUN
admet-1513	37	25	that	that	PRON
admet-1513	37	26	combine	combine	VERB
admet-1513	37	27	2d	2d	NUM
admet-1513	37	28	culture	culture	NOUN
admet-1513	37	29	with	with	ADP
admet-1513	37	30	biomedical	biomedical	PROPN
admet-1513	37	31	micro	micro	ADJ
admet-1513	37	32	-	-	ADJ
admet-1513	37	33	electromechanical	electromechanical	ADJ
admet-1513	37	34	systems	system	NOUN
admet-1513	37	35	.	.	PUNCT
admet-1513	38	1	as	as	ADP
admet-1513	38	2	a	a	DET
admet-1513	38	3	result	result	NOUN
admet-1513	38	4	,	,	PUNCT
admet-1513	38	5	when	when	SCONJ
admet-1513	38	6	drugs	drug	NOUN
admet-1513	38	7	are	be	AUX
admet-1513	38	8	tested	test	VERB
admet-1513	38	9	in	in	ADP
admet-1513	38	10	2d	2d	NUM
admet-1513	38	11	or	or	CCONJ
admet-1513	38	12	3d	3d	NUM
admet-1513	38	13	cultures	culture	NOUN
admet-1513	38	14	,	,	PUNCT
admet-1513	38	15	their	their	PRON
admet-1513	38	16	effectiveness	effectiveness	NOUN
admet-1513	38	17	substantially	substantially	ADV
admet-1513	38	18	changes	change	NOUN
admet-1513	38	19	,	,	PUNCT
admet-1513	38	20	as	as	SCONJ
admet-1513	38	21	3d	3d	NUM
admet-1513	38	22	cultures	culture	NOUN
admet-1513	38	23	are	be	AUX
admet-1513	38	24	more	more	ADV
admet-1513	38	25	resistant	resistant	ADJ
admet-1513	38	26	to	to	ADP
admet-1513	38	27	drug	drug	NOUN
admet-1513	38	28	treatments	treatment	NOUN
admet-1513	38	29	compared	compare	VERB
admet-1513	38	30	to	to	ADP
admet-1513	38	31	2d	2d	NUM
admet-1513	38	32	monolayers	monolayer	NOUN
admet-1513	38	33	,	,	PUNCT
admet-1513	38	34	which	which	PRON
admet-1513	38	35	is	be	AUX
admet-1513	38	36	analogous	analogous	ADJ
admet-1513	38	37	to	to	ADP
admet-1513	38	38	what	what	PRON
admet-1513	38	39	occurs	occur	VERB
admet-1513	38	40	in	in	ADP
admet-1513	38	41	the	the	DET
admet-1513	38	42	human	human	ADJ
admet-1513	38	43	body	body	NOUN
admet-1513	38	44	[	[	X
admet-1513	38	45	5	5	NUM
admet-1513	38	46	]	]	PUNCT
admet-1513	38	47	.	.	PUNCT
admet-1513	39	1	this	this	DET
admet-1513	39	2	article	article	NOUN
admet-1513	39	3	reviews	review	VERB
admet-1513	39	4	the	the	DET
admet-1513	39	5	current	current	ADJ
admet-1513	39	6	2d	2d	NUM
admet-1513	39	7	cell	cell	NOUN
admet-1513	39	8	line	line	NOUN
admet-1513	39	9	models	model	NOUN
admet-1513	39	10	used	use	VERB
admet-1513	39	11	in	in	ADP
admet-1513	39	12	adme	adme	NOUN
admet-1513	39	13	-	-	PUNCT
admet-1513	39	14	tox	tox	NOUN
admet-1513	39	15	screening	screening	NOUN
admet-1513	39	16	and	and	CCONJ
admet-1513	39	17	the	the	DET
admet-1513	39	18	applications	application	NOUN
admet-1513	39	19	and	and	CCONJ
admet-1513	39	20	challenges	challenge	NOUN
admet-1513	39	21	of	of	ADP
admet-1513	39	22	3d	3d	ADJ
admet-1513	39	23	organoids	organoid	NOUN
admet-1513	39	24	and	and	CCONJ
admet-1513	39	25	mps	mps	PROPN
admet-1513	39	26	models	model	NOUN
admet-1513	39	27	in	in	ADP
admet-1513	39	28	adme	adme	NOUN
admet-1513	39	29	tox	tox	NOUN
admet-1513	39	30	studies	study	NOUN
admet-1513	39	31	.	.	PUNCT
admet-1513	40	1	2d	2d	NUM
admet-1513	40	2	cell	cell	NOUN
admet-1513	40	3	culture	culture	NOUN
admet-1513	40	4	systems	system	NOUN
admet-1513	40	5	to	to	PART
admet-1513	40	6	evaluate	evaluate	VERB
admet-1513	40	7	adme	adme	NOUN
admet-1513	40	8	-	-	PUNCT
admet-1513	40	9	tox	tox	NOUN
admet-1513	40	10	screening	screening	NOUN
admet-1513	40	11	absorption	absorption	NOUN
admet-1513	40	12	the	the	DET
admet-1513	40	13	major	major	ADJ
admet-1513	40	14	aim	aim	NOUN
admet-1513	40	15	of	of	ADP
admet-1513	40	16	the	the	DET
admet-1513	40	17	drug	drug	NOUN
admet-1513	40	18	discovery	discovery	NOUN
admet-1513	40	19	program	program	NOUN
admet-1513	40	20	is	be	AUX
admet-1513	40	21	to	to	PART
admet-1513	40	22	get	get	VERB
admet-1513	40	23	a	a	DET
admet-1513	40	24	candidate	candidate	NOUN
admet-1513	40	25	that	that	PRON
admet-1513	40	26	has	have	VERB
admet-1513	40	27	a	a	DET
admet-1513	40	28	therapeutic	therapeutic	ADJ
admet-1513	40	29	effect	effect	NOUN
admet-1513	40	30	at	at	ADP
admet-1513	40	31	the	the	DET
admet-1513	40	32	site	site	NOUN
admet-1513	40	33	of	of	ADP
admet-1513	40	34	action	action	NOUN
admet-1513	40	35	and	and	CCONJ
admet-1513	40	36	is	be	AUX
admet-1513	40	37	eliminated	eliminate	VERB
admet-1513	40	38	in	in	ADP
admet-1513	40	39	a	a	DET
admet-1513	40	40	particular	particular	ADJ
admet-1513	40	41	time	time	NOUN
admet-1513	40	42	frame	frame	NOUN
admet-1513	40	43	[	[	X
admet-1513	40	44	5	5	NUM
admet-1513	40	45	]	]	PUNCT
admet-1513	40	46	.	.	PUNCT
admet-1513	41	1	most	most	ADJ
admet-1513	41	2	drugs	drug	NOUN
admet-1513	41	3	are	be	AUX
admet-1513	41	4	designed	design	VERB
admet-1513	41	5	for	for	ADP
admet-1513	41	6	oral	oral	ADJ
admet-1513	41	7	administration	administration	NOUN
admet-1513	41	8	because	because	SCONJ
admet-1513	41	9	it	it	PRON
admet-1513	41	10	makes	make	VERB
admet-1513	41	11	it	it	PRON
admet-1513	41	12	easy	easy	ADJ
admet-1513	41	13	for	for	ADP
admet-1513	41	14	patients	patient	NOUN
admet-1513	41	15	to	to	ADP
admet-1513	41	16	self	self	NOUN
admet-1513	41	17	-	-	PUNCT
admet-1513	41	18	administer	administer	NOUN
admet-1513	41	19	.	.	PUNCT
admet-1513	42	1	drugs	drug	NOUN
admet-1513	42	2	administered	administer	VERB
admet-1513	42	3	orally	orally	ADV
admet-1513	42	4	should	should	AUX
admet-1513	42	5	pass	pass	VERB
admet-1513	42	6	through	through	ADP
admet-1513	42	7	the	the	DET
admet-1513	42	8	gastrointestinal	gastrointestinal	ADJ
admet-1513	42	9	tract	tract	NOUN
admet-1513	42	10	,	,	PUNCT
admet-1513	42	11	be	be	AUX
admet-1513	42	12	absorbed	absorb	VERB
admet-1513	42	13	,	,	PUNCT
admet-1513	42	14	and	and	CCONJ
admet-1513	42	15	sent	send	VERB
admet-1513	42	16	to	to	ADP
admet-1513	42	17	the	the	DET
admet-1513	42	18	liver	liver	NOUN
admet-1513	42	19	through	through	ADP
admet-1513	42	20	the	the	DET
admet-1513	42	21	hepatic	hepatic	ADJ
admet-1513	42	22	portal	portal	ADJ
admet-1513	42	23	system	system	NOUN
admet-1513	42	24	,	,	PUNCT
admet-1513	42	25	where	where	SCONJ
admet-1513	42	26	it	it	PRON
admet-1513	42	27	gets	get	AUX
admet-1513	42	28	metabolized	metabolize	VERB
admet-1513	42	29	or	or	CCONJ
admet-1513	42	30	distributed	distribute	VERB
admet-1513	42	31	to	to	ADP
admet-1513	42	32	the	the	DET
admet-1513	42	33	site	site	NOUN
admet-1513	42	34	of	of	ADP
admet-1513	42	35	action	action	NOUN
admet-1513	42	36	.	.	PUNCT
admet-1513	43	1	absorption	absorption	NOUN
admet-1513	43	2	is	be	AUX
admet-1513	43	3	the	the	DET
admet-1513	43	4	first	first	ADJ
admet-1513	43	5	biological	biological	ADJ
admet-1513	43	6	process	process	NOUN
admet-1513	43	7	in	in	ADP
admet-1513	43	8	the	the	DET
admet-1513	43	9	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	43	10	parameter	parameter	NOUN
admet-1513	43	11	of	of	ADP
admet-1513	43	12	the	the	DET
admet-1513	43	13	drug	drug	NOUN
admet-1513	43	14	,	,	PUNCT
admet-1513	43	15	which	which	PRON
admet-1513	43	16	mainly	mainly	ADV
admet-1513	43	17	occurs	occur	VERB
admet-1513	43	18	at	at	ADP
admet-1513	43	19	the	the	DET
admet-1513	43	20	intestinal	intestinal	ADJ
admet-1513	43	21	level	level	NOUN
admet-1513	43	22	[	[	X
admet-1513	43	23	13	13	NUM
admet-1513	43	24	]	]	PUNCT
admet-1513	43	25	.	.	PUNCT
admet-1513	44	1	hence	hence	ADV
admet-1513	44	2	during	during	ADP
admet-1513	44	3	the	the	DET
admet-1513	44	4	drug	drug	NOUN
admet-1513	44	5	discovery	discovery	NOUN
admet-1513	44	6	process	process	NOUN
admet-1513	44	7	,	,	PUNCT
admet-1513	44	8	developing	develop	VERB
admet-1513	44	9	drugs	drug	NOUN
admet-1513	44	10	that	that	PRON
admet-1513	44	11	can	can	AUX
admet-1513	44	12	efficiently	efficiently	ADV
admet-1513	44	13	penetrate	penetrate	VERB
admet-1513	44	14	the	the	DET
admet-1513	44	15	gut	gut	NOUN
admet-1513	44	16	epithelium	epithelium	NOUN
admet-1513	44	17	is	be	AUX
admet-1513	44	18	critical	critical	ADJ
admet-1513	44	19	.	.	PUNCT
admet-1513	45	1	the	the	DET
admet-1513	45	2	admet	admet	PROPN
admet-1513	45	3	&	&	CCONJ
admet-1513	45	4	dmpk	dmpk	PROPN
admet-1513	45	5	11(1	11(1	NUM
admet-1513	45	6	)	)	PUNCT
admet-1513	45	7	(	(	PUNCT
admet-1513	45	8	2023	2023	NUM
admet-1513	45	9	)	)	PUNCT
admet-1513	45	10	1	1	NUM
admet-1513	45	11	-	-	SYM
admet-1513	45	12	32	32	NUM
admet-1513	45	13	2d	2d	NOUN
admet-1513	45	14	and	and	CCONJ
admet-1513	45	15	3d	3d	NOUN
admet-1513	45	16	adme	adme	PROPN
admet-1513	45	17	-	-	PUNCT
admet-1513	45	18	tox	tox	NOUN
admet-1513	45	19	cell	cell	NOUN
admet-1513	45	20	culture	culture	NOUN
admet-1513	45	21	screening	screen	VERB
admet-1513	45	22	:	:	PUNCT
admet-1513	45	23	a	a	DET
admet-1513	45	24	review	review	NOUN
admet-1513	45	25	doi	doi	NOUN
admet-1513	45	26	:	:	PUNCT
admet-1513	45	27	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	45	28	3	3	NUM
admet-1513	45	29	absorption	absorption	NOUN
admet-1513	45	30	in	in	ADP
admet-1513	45	31	the	the	DET
admet-1513	45	32	intestine	intestine	NOUN
admet-1513	45	33	is	be	AUX
admet-1513	45	34	majorly	majorly	ADV
admet-1513	45	35	hindered	hinder	VERB
admet-1513	45	36	by	by	ADP
admet-1513	45	37	the	the	DET
admet-1513	45	38	intestinal	intestinal	ADJ
admet-1513	45	39	epithelial	epithelial	ADJ
admet-1513	45	40	membrane	membrane	NOUN
admet-1513	45	41	composed	compose	VERB
admet-1513	45	42	of	of	ADP
admet-1513	45	43	monolayer	monolayer	NOUN
admet-1513	45	44	columnar	columnar	NOUN
admet-1513	45	45	cells	cell	NOUN
admet-1513	45	46	comprising	comprise	VERB
admet-1513	45	47	:	:	PUNCT
admet-1513	45	48	1	1	X
admet-1513	45	49	.	.	NUM
admet-1513	45	50	enterocytes	enterocyte	NOUN
admet-1513	45	51	are	be	AUX
admet-1513	45	52	characterized	characterize	VERB
admet-1513	45	53	by	by	ADP
admet-1513	45	54	the	the	DET
admet-1513	45	55	presence	presence	NOUN
admet-1513	45	56	of	of	ADP
admet-1513	45	57	apical	apical	ADJ
admet-1513	45	58	villi	villi	NOUN
admet-1513	45	59	and	and	CCONJ
admet-1513	45	60	microvilli	microvilli	NOUN
admet-1513	45	61	over	over	ADP
admet-1513	45	62	them	they	PRON
admet-1513	45	63	,	,	PUNCT
admet-1513	45	64	which	which	PRON
admet-1513	45	65	regulates	regulate	VERB
admet-1513	45	66	the	the	DET
admet-1513	45	67	diffusion	diffusion	NOUN
admet-1513	45	68	of	of	ADP
admet-1513	45	69	small	small	ADJ
admet-1513	45	70	compounds	compound	NOUN
admet-1513	45	71	.	.	PUNCT
admet-1513	46	1	they	they	PRON
admet-1513	46	2	also	also	ADV
admet-1513	46	3	produce	produce	VERB
admet-1513	46	4	a	a	DET
admet-1513	46	5	large	large	ADJ
admet-1513	46	6	amount	amount	NOUN
admet-1513	46	7	of	of	ADP
admet-1513	46	8	food	food	NOUN
admet-1513	46	9	and	and	CCONJ
admet-1513	46	10	drugmetabolizing	drugmetabolizing	NOUN
admet-1513	46	11	enzymes	enzyme	NOUN
admet-1513	46	12	for	for	ADP
admet-1513	46	13	exogenous	exogenous	ADJ
admet-1513	46	14	substance	substance	NOUN
admet-1513	46	15	protection	protection	NOUN
admet-1513	46	16	.	.	PUNCT
admet-1513	47	1	2	2	X
admet-1513	47	2	.	.	X
admet-1513	47	3	enteroendocrine	enteroendocrine	ADJ
admet-1513	47	4	cells	cell	NOUN
admet-1513	47	5	,	,	PUNCT
admet-1513	47	6	characterized	characterize	VERB
admet-1513	47	7	by	by	ADP
admet-1513	47	8	releasing	release	VERB
admet-1513	47	9	peptide	peptide	ADJ
admet-1513	47	10	hormones	hormone	NOUN
admet-1513	47	11	,	,	PUNCT
admet-1513	47	12	and	and	CCONJ
admet-1513	47	13	3	3	X
admet-1513	47	14	.	.	PUNCT
admet-1513	47	15	goblet	goblet	NOUN
admet-1513	47	16	cells	cell	NOUN
admet-1513	47	17	produce	produce	VERB
admet-1513	47	18	mucous	mucous	ADJ
admet-1513	47	19	covering	cover	VERB
admet-1513	47	20	the	the	DET
admet-1513	47	21	intestinal	intestinal	ADJ
admet-1513	47	22	epithelium	epithelium	NOUN
admet-1513	47	23	.	.	PUNCT
admet-1513	48	1	in	in	ADP
admet-1513	48	2	fact	fact	NOUN
admet-1513	48	3	,	,	PUNCT
admet-1513	48	4	the	the	DET
admet-1513	48	5	mucous	mucous	ADJ
admet-1513	48	6	layer	layer	NOUN
admet-1513	48	7	is	be	AUX
admet-1513	48	8	the	the	DET
admet-1513	48	9	first	first	ADJ
admet-1513	48	10	barrier	barrier	NOUN
admet-1513	48	11	that	that	PRON
admet-1513	48	12	filters	filter	VERB
admet-1513	48	13	nutrient	nutrient	ADJ
admet-1513	48	14	absorption	absorption	NOUN
admet-1513	48	15	by	by	ADP
admet-1513	48	16	maintaining	maintain	VERB
admet-1513	48	17	intestinal	intestinal	ADJ
admet-1513	48	18	homeostasis	homeostasis	NOUN
admet-1513	48	19	[	[	X
admet-1513	48	20	14	14	NUM
admet-1513	48	21	]	]	SYM
admet-1513	48	22	.	.	PUNCT
admet-1513	49	1	4	4	X
admet-1513	49	2	.	.	X
admet-1513	49	3	intestinal	intestinal	ADJ
admet-1513	49	4	stem	stem	NOUN
admet-1513	49	5	cells	cell	NOUN
admet-1513	49	6	(	(	PUNCT
admet-1513	49	7	lgr5(+	lgr5(+	ADJ
admet-1513	49	8	)	)	PUNCT
admet-1513	49	9	)	)	PUNCT
admet-1513	49	10	help	help	NOUN
admet-1513	49	11	maintain	maintain	VERB
admet-1513	49	12	other	other	ADJ
admet-1513	49	13	cells	cell	NOUN
admet-1513	49	14	'	'	PART
admet-1513	49	15	integrity	integrity	NOUN
admet-1513	49	16	and	and	CCONJ
admet-1513	49	17	function	function	NOUN
admet-1513	49	18	by	by	ADP
admet-1513	49	19	rapid	rapid	ADJ
admet-1513	49	20	dividing	dividing	NOUN
admet-1513	49	21	and	and	CCONJ
admet-1513	49	22	differentiation	differentiation	NOUN
admet-1513	49	23	.	.	PUNCT
admet-1513	50	1	5	5	X
admet-1513	50	2	.	.	NOUN
admet-1513	50	3	paneth	paneth	PROPN
admet-1513	50	4	cells	cell	NOUN
admet-1513	50	5	,	,	PUNCT
admet-1513	50	6	which	which	PRON
admet-1513	50	7	help	help	VERB
admet-1513	50	8	in	in	ADP
admet-1513	50	9	providing	provide	VERB
admet-1513	50	10	support	support	NOUN
admet-1513	50	11	and	and	CCONJ
admet-1513	50	12	secretion	secretion	NOUN
admet-1513	50	13	of	of	ADP
admet-1513	50	14	growth	growth	NOUN
admet-1513	50	15	factors	factor	NOUN
admet-1513	50	16	and	and	CCONJ
admet-1513	50	17	antimicrobial	antimicrobial	ADJ
admet-1513	50	18	peptides	peptide	NOUN
admet-1513	50	19	[	[	X
admet-1513	50	20	5	5	NUM
admet-1513	50	21	]	]	PUNCT
admet-1513	50	22	.	.	PUNCT
admet-1513	51	1	the	the	DET
admet-1513	51	2	absorption	absorption	NOUN
admet-1513	51	3	of	of	ADP
admet-1513	51	4	the	the	DET
admet-1513	51	5	drugs	drug	NOUN
admet-1513	51	6	from	from	ADP
admet-1513	51	7	the	the	DET
admet-1513	51	8	luminal	luminal	ADJ
admet-1513	51	9	side	side	NOUN
admet-1513	51	10	to	to	ADP
admet-1513	51	11	mesenteric	mesenteric	ADJ
admet-1513	51	12	vessels	vessel	NOUN
admet-1513	51	13	on	on	ADP
admet-1513	51	14	the	the	DET
admet-1513	51	15	basolateral	basolateral	ADJ
admet-1513	51	16	side	side	NOUN
admet-1513	51	17	follows	follow	VERB
admet-1513	51	18	either	either	ADV
admet-1513	51	19	:	:	PUNCT
admet-1513	51	20	1	1	X
admet-1513	51	21	.	.	PUNCT
admet-1513	51	22	passive	passive	ADJ
admet-1513	51	23	transport	transport	NOUN
admet-1513	51	24	,	,	PUNCT
admet-1513	51	25	via	via	ADP
admet-1513	51	26	transcellular	transcellular	NOUN
admet-1513	51	27	,	,	PUNCT
admet-1513	51	28	i.e.	i.e.	X
admet-1513	51	29	,	,	PUNCT
admet-1513	51	30	passing	pass	VERB
admet-1513	51	31	through	through	ADP
admet-1513	51	32	the	the	DET
admet-1513	51	33	cell	cell	NOUN
admet-1513	51	34	membrane	membrane	NOUN
admet-1513	51	35	(	(	PUNCT
admet-1513	51	36	mostly	mostly	ADV
admet-1513	51	37	lipophilic	lipophilic	ADJ
admet-1513	51	38	)	)	PUNCT
admet-1513	52	1	[	[	X
admet-1513	52	2	15	15	NUM
admet-1513	52	3	]	]	PUNCT
admet-1513	52	4	or	or	CCONJ
admet-1513	52	5	paracellular	paracellular	ADJ
admet-1513	52	6	,	,	PUNCT
admet-1513	52	7	i.e.	i.e.	X
admet-1513	52	8	,	,	PUNCT
admet-1513	52	9	passing	pass	VERB
admet-1513	52	10	through	through	ADP
admet-1513	52	11	tight	tight	ADJ
admet-1513	52	12	junctions	junction	NOUN
admet-1513	52	13	or	or	CCONJ
admet-1513	52	14	intercellular	intercellular	ADJ
admet-1513	52	15	spaces	space	NOUN
admet-1513	52	16	(	(	PUNCT
admet-1513	52	17	mostly	mostly	ADV
admet-1513	52	18	hydrophilic	hydrophilic	ADJ
admet-1513	52	19	)	)	PUNCT
admet-1513	53	1	[	[	X
admet-1513	53	2	16	16	NUM
admet-1513	53	3	]	]	PUNCT
admet-1513	53	4	.	.	PUNCT
admet-1513	54	1	2	2	X
admet-1513	54	2	.	.	X
admet-1513	54	3	active	active	ADJ
admet-1513	54	4	transport	transport	NOUN
admet-1513	54	5	,	,	PUNCT
admet-1513	54	6	via	via	ADP
admet-1513	54	7	influx	influx	NOUN
admet-1513	54	8	and	and	CCONJ
admet-1513	54	9	efflux	efflux	VERB
admet-1513	54	10	through	through	ADP
admet-1513	54	11	transporters	transporter	NOUN
admet-1513	54	12	present	present	ADJ
admet-1513	54	13	on	on	ADP
admet-1513	54	14	the	the	DET
admet-1513	54	15	apical	apical	ADJ
admet-1513	54	16	and	and	CCONJ
admet-1513	54	17	basolateral	basolateral	ADJ
admet-1513	54	18	side	side	NOUN
admet-1513	54	19	cell	cell	NOUN
admet-1513	54	20	membrane	membrane	NOUN
admet-1513	54	21	or	or	CCONJ
admet-1513	54	22	vesicular	vesicular	ADJ
admet-1513	54	23	mediated	mediate	VERB
admet-1513	54	24	endoor	endoor	NOUN
admet-1513	54	25	trans	trans	NOUN
admet-1513	54	26	-	-	NOUN
admet-1513	54	27	cytosis	cytosis	NOUN
admet-1513	54	28	[	[	X
admet-1513	54	29	17	17	NUM
admet-1513	54	30	]	]	PUNCT
admet-1513	54	31	.	.	PUNCT
admet-1513	55	1	cell	cell	NOUN
admet-1513	55	2	-	-	PUNCT
admet-1513	55	3	based	base	VERB
admet-1513	55	4	models	model	NOUN
admet-1513	55	5	not	not	PART
admet-1513	55	6	only	only	ADV
admet-1513	55	7	can	can	AUX
admet-1513	55	8	mimic	mimic	VERB
admet-1513	55	9	the	the	PRON
admet-1513	55	10	in	in	ADP
admet-1513	55	11	vivo	vivo	ADJ
admet-1513	55	12	anatomical	anatomical	ADJ
admet-1513	55	13	,	,	PUNCT
admet-1513	55	14	biochemical	biochemical	ADJ
admet-1513	55	15	and	and	CCONJ
admet-1513	55	16	structural	structural	ADJ
admet-1513	55	17	features	feature	NOUN
admet-1513	55	18	of	of	ADP
admet-1513	55	19	the	the	DET
admet-1513	55	20	small	small	ADJ
admet-1513	55	21	intestine	intestine	NOUN
admet-1513	55	22	but	but	CCONJ
admet-1513	55	23	also	also	ADV
admet-1513	55	24	help	help	VERB
admet-1513	55	25	in	in	ADP
admet-1513	55	26	reproducing	reproduce	VERB
admet-1513	55	27	the	the	DET
admet-1513	55	28	study	study	NOUN
admet-1513	55	29	of	of	ADP
admet-1513	55	30	both	both	CCONJ
admet-1513	55	31	passive	passive	ADJ
admet-1513	55	32	diffusion	diffusion	NOUN
admet-1513	55	33	and	and	CCONJ
admet-1513	55	34	active	active	ADJ
admet-1513	55	35	transport	transport	NOUN
admet-1513	55	36	process	process	NOUN
admet-1513	55	37	[	[	X
admet-1513	55	38	5	5	NUM
admet-1513	55	39	]	]	PUNCT
admet-1513	55	40	.	.	PUNCT
admet-1513	56	1	to	to	ADP
admet-1513	56	2	date	date	NOUN
admet-1513	56	3	,	,	PUNCT
admet-1513	56	4	many	many	ADJ
admet-1513	56	5	immortalized	immortalize	VERB
admet-1513	56	6	cell	cell	NOUN
admet-1513	56	7	cultures	culture	NOUN
admet-1513	56	8	are	be	AUX
admet-1513	56	9	used	use	VERB
admet-1513	56	10	by	by	ADP
admet-1513	56	11	researchers	researcher	NOUN
admet-1513	56	12	to	to	PART
admet-1513	56	13	predict	predict	VERB
admet-1513	56	14	the	the	DET
admet-1513	56	15	permeability	permeability	NOUN
admet-1513	56	16	and	and	CCONJ
admet-1513	56	17	absorption	absorption	NOUN
admet-1513	56	18	of	of	ADP
admet-1513	56	19	drugs	drug	NOUN
admet-1513	56	20	.	.	PUNCT
admet-1513	57	1	the	the	DET
admet-1513	57	2	absorption	absorption	NOUN
admet-1513	57	3	models	model	NOUN
admet-1513	57	4	will	will	AUX
admet-1513	57	5	help	help	VERB
admet-1513	57	6	us	we	PRON
admet-1513	57	7	to	to	PART
admet-1513	57	8	determine	determine	VERB
admet-1513	57	9	the	the	DET
admet-1513	57	10	rate	rate	NOUN
admet-1513	57	11	of	of	ADP
admet-1513	57	12	transfer	transfer	NOUN
admet-1513	57	13	per	per	ADP
admet-1513	57	14	unit	unit	NOUN
admet-1513	57	15	area	area	NOUN
admet-1513	57	16	(	(	PUNCT
admet-1513	57	17	j	j	PROPN
admet-1513	57	18	)	)	PUNCT
admet-1513	57	19	which	which	PRON
admet-1513	57	20	follows	follow	VERB
admet-1513	57	21	fick	fick	PROPN
admet-1513	57	22	’s	’s	PART
admet-1513	57	23	law	law	NOUN
admet-1513	57	24	of	of	ADP
admet-1513	57	25	diffusion	diffusion	NOUN
admet-1513	57	26	and	and	CCONJ
admet-1513	57	27	apparent	apparent	ADJ
admet-1513	57	28	permeability	permeability	NOUN
admet-1513	57	29	co	co	ADJ
admet-1513	57	30	-	-	ADJ
admet-1513	57	31	efficient	efficient	ADJ
admet-1513	57	32	(	(	PUNCT
admet-1513	57	33	papp	papp	NOUN
admet-1513	57	34	)	)	PUNCT
admet-1513	57	35	,	,	PUNCT
admet-1513	57	36	which	which	PRON
admet-1513	57	37	indicates	indicate	VERB
admet-1513	57	38	the	the	DET
admet-1513	57	39	amount	amount	NOUN
admet-1513	57	40	of	of	ADP
admet-1513	57	41	drug	drug	NOUN
admet-1513	57	42	passing	pass	VERB
admet-1513	57	43	the	the	DET
admet-1513	57	44	barrier	barrier	NOUN
admet-1513	57	45	per	per	ADP
admet-1513	57	46	unit	unit	NOUN
admet-1513	57	47	area	area	NOUN
admet-1513	57	48	(	(	PUNCT
admet-1513	57	49	a	a	NOUN
admet-1513	57	50	)	)	PUNCT
admet-1513	57	51	.	.	PUNCT
admet-1513	58	1	these	these	PRON
admet-1513	58	2	are	be	AUX
admet-1513	58	3	determined	determine	VERB
admet-1513	58	4	by	by	ADP
admet-1513	58	5	using	use	VERB
admet-1513	58	6	the	the	DET
admet-1513	58	7	following	follow	VERB
admet-1513	58	8	equations	equation	NOUN
admet-1513	58	9	:	:	PUNCT
admet-1513	59	1			PROPN
admet-1513	59	2	d	d	X
admet-1513	59	3	/dj	/dj	PUNCT
admet-1513	60	1	d	d	X
admet-1513	60	2	c	c	NOUN
admet-1513	60	3	x	x	SYM
admet-1513	60	4	(	(	PUNCT
admet-1513	60	5	1	1	NUM
admet-1513	60	6	)	)	PUNCT
admet-1513	60	7	app	app	X
admet-1513	60	8	0	0	NUM
admet-1513	60	9	d	d	NOUN
admet-1513	60	10	/	/	SYM
admet-1513	61	1	dq	dq	PROPN
admet-1513	61	2	t	t	PROPN
admet-1513	61	3	p	p	X
admet-1513	61	4	ac	ac	PROPN
admet-1513	61	5	(	(	PUNCT
admet-1513	61	6	2	2	NUM
admet-1513	61	7	)	)	PUNCT
admet-1513	61	8	where	where	SCONJ
admet-1513	61	9	d	d	NOUN
admet-1513	61	10	is	be	AUX
admet-1513	61	11	diffusion	diffusion	NOUN
admet-1513	61	12	coefficient	coefficient	NOUN
admet-1513	61	13	(	(	PUNCT
admet-1513	61	14	cm2	cm2	NOUN
admet-1513	61	15	/	/	SYM
admet-1513	61	16	h	h	NOUN
admet-1513	61	17	)	)	PUNCT
admet-1513	61	18	,	,	PUNCT
admet-1513	61	19	dc	dc	PROPN
admet-1513	61	20	is	be	AUX
admet-1513	61	21	the	the	DET
admet-1513	61	22	concentration	concentration	NOUN
admet-1513	61	23	gradient	gradient	NOUN
admet-1513	61	24	(	(	PUNCT
admet-1513	61	25	g	g	NOUN
admet-1513	61	26	/	/	SYM
admet-1513	61	27	cm3	cm3	NOUN
admet-1513	61	28	)	)	PUNCT
admet-1513	61	29	,	,	PUNCT
admet-1513	61	30	dx	dx	PROPN
admet-1513	61	31	is	be	AUX
admet-1513	61	32	the	the	DET
admet-1513	61	33	linear	linear	ADJ
admet-1513	61	34	distance	distance	NOUN
admet-1513	61	35	traveled	travel	VERB
admet-1513	61	36	(	(	PUNCT
admet-1513	61	37	cm	cm	NOUN
admet-1513	61	38	)	)	PUNCT
admet-1513	61	39	,	,	PUNCT
admet-1513	61	40	dq	dq	PROPN
admet-1513	61	41	/	/	SYM
admet-1513	61	42	dt	dt	PROPN
admet-1513	61	43	indicates	indicate	VERB
admet-1513	61	44	the	the	DET
admet-1513	61	45	rate	rate	NOUN
admet-1513	61	46	of	of	ADP
admet-1513	61	47	drug	drug	NOUN
admet-1513	61	48	transferred	transfer	VERB
admet-1513	61	49	into	into	ADP
admet-1513	61	50	the	the	DET
admet-1513	61	51	acceptor	acceptor	NOUN
admet-1513	61	52	side	side	NOUN
admet-1513	61	53	and	and	CCONJ
admet-1513	61	54	c0	c0	NOUN
admet-1513	61	55	is	be	AUX
admet-1513	61	56	the	the	DET
admet-1513	61	57	initial	initial	ADJ
admet-1513	61	58	drug	drug	NOUN
admet-1513	61	59	concentration	concentration	NOUN
admet-1513	61	60	in	in	ADP
admet-1513	61	61	the	the	DET
admet-1513	61	62	donor	donor	NOUN
admet-1513	61	63	side	side	NOUN
admet-1513	62	1	[	[	X
admet-1513	62	2	5	5	NUM
admet-1513	62	3	]	]	PUNCT
admet-1513	62	4	.	.	PUNCT
admet-1513	63	1	artificial	artificial	ADJ
admet-1513	63	2	models	model	NOUN
admet-1513	63	3	for	for	ADP
admet-1513	63	4	absorption	absorption	NOUN
admet-1513	63	5	the	the	DET
admet-1513	63	6	most	most	ADV
admet-1513	63	7	commonly	commonly	ADV
admet-1513	63	8	used	use	VERB
admet-1513	63	9	2d	2d	NOUN
admet-1513	63	10	in	in	ADP
admet-1513	63	11	vitro	vitro	X
admet-1513	63	12	models	model	NOUN
admet-1513	63	13	are	be	AUX
admet-1513	63	14	synthetic	synthetic	ADJ
admet-1513	63	15	or	or	CCONJ
admet-1513	63	16	cell	cell	NOUN
admet-1513	63	17	line	line	NOUN
admet-1513	63	18	based	base	VERB
admet-1513	63	19	.	.	PUNCT
admet-1513	64	1	both	both	DET
admet-1513	64	2	these	these	DET
admet-1513	64	3	procedures	procedure	NOUN
admet-1513	64	4	have	have	VERB
admet-1513	64	5	a	a	DET
admet-1513	64	6	donor	donor	NOUN
admet-1513	64	7	plate	plate	NOUN
admet-1513	64	8	comprising	comprise	VERB
admet-1513	64	9	a	a	DET
admet-1513	64	10	permeable	permeable	ADJ
admet-1513	64	11	membrane	membrane	NOUN
admet-1513	64	12	or	or	CCONJ
admet-1513	64	13	filter	filter	NOUN
admet-1513	64	14	on	on	ADP
admet-1513	64	15	which	which	PRON
admet-1513	64	16	a	a	DET
admet-1513	64	17	synthetic	synthetic	ADJ
admet-1513	64	18	phospholipid	phospholipid	NOUN
admet-1513	64	19	bilayer	bilayer	NOUN
admet-1513	64	20	is	be	AUX
admet-1513	64	21	attached	attach	VERB
admet-1513	64	22	,	,	PUNCT
admet-1513	64	23	thus	thus	ADV
admet-1513	64	24	mimicking	mimic	VERB
admet-1513	64	25	the	the	DET
admet-1513	64	26	intestinal	intestinal	ADJ
admet-1513	64	27	niche	niche	NOUN
admet-1513	64	28	.	.	PUNCT
admet-1513	65	1	synthetic	synthetic	ADJ
admet-1513	65	2	models	model	NOUN
admet-1513	65	3	such	such	ADJ
admet-1513	65	4	as	as	ADP
admet-1513	65	5	parallel	parallel	ADJ
admet-1513	65	6	artificial	artificial	ADJ
admet-1513	65	7	membrane	membrane	NOUN
admet-1513	65	8	permeability	permeability	NOUN
admet-1513	65	9	assay	assay	NOUN
admet-1513	65	10	(	(	PUNCT
admet-1513	65	11	pampa	pampa	PROPN
admet-1513	65	12	)	)	PUNCT
admet-1513	66	1	[	[	X
admet-1513	66	2	18	18	NUM
admet-1513	66	3	]	]	PUNCT
admet-1513	66	4	and	and	CCONJ
admet-1513	66	5	phospholipid	phospholipid	NOUN
admet-1513	66	6	vesicle	vesicle	NOUN
admet-1513	66	7	-	-	PUNCT
admet-1513	66	8	based	base	VERB
admet-1513	66	9	permeation	permeation	NOUN
admet-1513	66	10	assay	assay	NOUN
admet-1513	66	11	(	(	PUNCT
admet-1513	66	12	pvpa	pvpa	NOUN
admet-1513	66	13	)	)	PUNCT
admet-1513	67	1	[	[	X
admet-1513	67	2	19	19	NUM
admet-1513	67	3	]	]	PUNCT
admet-1513	67	4	are	be	AUX
admet-1513	67	5	the	the	DET
admet-1513	67	6	cellfree	cellfree	ADJ
admet-1513	67	7	permeation	permeation	NOUN
admet-1513	67	8	systems	system	NOUN
admet-1513	67	9	that	that	PRON
admet-1513	67	10	help	help	VERB
admet-1513	67	11	in	in	ADP
admet-1513	67	12	reproducing	reproduce	VERB
admet-1513	67	13	the	the	DET
admet-1513	67	14	study	study	NOUN
admet-1513	67	15	of	of	ADP
admet-1513	67	16	passive	passive	ADJ
admet-1513	67	17	diffusion	diffusion	NOUN
admet-1513	67	18	processes	process	NOUN
admet-1513	67	19	.	.	PUNCT
admet-1513	68	1	both	both	DET
admet-1513	68	2	these	these	DET
admet-1513	68	3	processes	process	NOUN
admet-1513	68	4	use	use	VERB
admet-1513	68	5	an	an	DET
admet-1513	68	6	artificial	artificial	ADJ
admet-1513	68	7	membrane	membrane	NOUN
admet-1513	68	8	that	that	PRON
admet-1513	68	9	mimics	mimic	VERB
admet-1513	68	10	the	the	DET
admet-1513	68	11	phosphor	phosphor	NOUN
admet-1513	68	12	-	-	PUNCT
admet-1513	68	13	lipid	lipid	ADJ
admet-1513	68	14	bilayer	bilayer	NOUN
admet-1513	68	15	of	of	ADP
admet-1513	68	16	the	the	DET
admet-1513	68	17	intestinal	intestinal	ADJ
admet-1513	68	18	enterocytes	enterocyte	NOUN
admet-1513	68	19	.	.	PUNCT
admet-1513	69	1	the	the	DET
admet-1513	69	2	major	major	ADJ
admet-1513	69	3	difference	difference	NOUN
admet-1513	69	4	between	between	ADP
admet-1513	69	5	these	these	DET
admet-1513	69	6	two	two	NUM
admet-1513	69	7	methods	method	NOUN
admet-1513	69	8	is	be	AUX
admet-1513	69	9	in	in	ADP
admet-1513	69	10	pampa	pampa	PROPN
admet-1513	69	11	,	,	PUNCT
admet-1513	69	12	the	the	DET
admet-1513	69	13	phospho	phospho	ADJ
admet-1513	69	14	-	-	PUNCT
admet-1513	69	15	lipid	lipid	NOUN
admet-1513	69	16	membrane	membrane	NOUN
admet-1513	69	17	is	be	AUX
admet-1513	69	18	dissolved	dissolve	VERB
admet-1513	69	19	in	in	ADP
admet-1513	69	20	an	an	DET
admet-1513	69	21	organic	organic	ADJ
admet-1513	69	22	solvent	solvent	NOUN
admet-1513	69	23	,	,	PUNCT
admet-1513	69	24	whereas	whereas	SCONJ
admet-1513	69	25	in	in	ADP
admet-1513	69	26	pvpa	pvpa	NOUN
admet-1513	69	27	,	,	PUNCT
admet-1513	69	28	it	it	PRON
admet-1513	69	29	is	be	AUX
admet-1513	69	30	organic	organic	ADJ
admet-1513	69	31	solvent	solvent	NOUN
admet-1513	69	32	-	-	PUNCT
admet-1513	69	33	free	free	ADJ
admet-1513	69	34	,	,	PUNCT
admet-1513	69	35	and	and	CCONJ
admet-1513	69	36	the	the	DET
admet-1513	69	37	structure	structure	NOUN
admet-1513	69	38	is	be	AUX
admet-1513	69	39	made	make	VERB
admet-1513	69	40	up	up	ADP
admet-1513	69	41	of	of	ADP
admet-1513	69	42	a	a	DET
admet-1513	69	43	tight	tight	ADJ
admet-1513	69	44	barrier	barrier	NOUN
admet-1513	69	45	comprising	comprising	NOUN
admet-1513	69	46	of	of	ADP
admet-1513	69	47	liposomes	liposome	NOUN
admet-1513	69	48	between	between	ADP
admet-1513	69	49	the	the	DET
admet-1513	69	50	pores	pore	NOUN
admet-1513	69	51	and	and	CCONJ
admet-1513	69	52	on	on	ADP
admet-1513	69	53	the	the	DET
admet-1513	69	54	top	top	NOUN
admet-1513	69	55	of	of	ADP
admet-1513	69	56	it	it	PRON
admet-1513	69	57	is	be	AUX
admet-1513	69	58	phospholipid	phospholipid	NOUN
admet-1513	69	59	bilayer	bilayer	NOUN
admet-1513	70	1	[	[	X
admet-1513	70	2	20	20	NUM
admet-1513	70	3	]	]	PUNCT
admet-1513	70	4	.	.	PUNCT
admet-1513	71	1	both	both	DET
admet-1513	71	2	these	these	DET
admet-1513	71	3	methods	method	NOUN
admet-1513	71	4	are	be	AUX
admet-1513	71	5	considered	consider	VERB
admet-1513	71	6	best	good	ADJ
admet-1513	71	7	in	in	ADP
admet-1513	71	8	assessing	assess	VERB
admet-1513	71	9	the	the	DET
admet-1513	71	10	absorptive	absorptive	ADJ
admet-1513	71	11	potential	potential	NOUN
admet-1513	71	12	of	of	ADP
admet-1513	71	13	lipophilic	lipophilic	ADJ
admet-1513	71	14	drugs	drug	NOUN
admet-1513	71	15	with	with	ADP
admet-1513	71	16	high	high	ADJ
admet-1513	71	17	reproducibility	reproducibility	NOUN
admet-1513	71	18	,	,	PUNCT
admet-1513	71	19	cost	cost	NOUN
admet-1513	71	20	-	-	PUNCT
admet-1513	71	21	effectiveness	effectiveness	NOUN
admet-1513	71	22	and	and	CCONJ
admet-1513	71	23	easy	easy	ADJ
admet-1513	71	24	handling	handling	NOUN
admet-1513	71	25	compared	compare	VERB
admet-1513	71	26	to	to	ADP
admet-1513	71	27	cell	cell	NOUN
admet-1513	71	28	-	-	PUNCT
admet-1513	71	29	based	base	VERB
admet-1513	71	30	assays	assay	NOUN
admet-1513	72	1	[	[	X
admet-1513	72	2	21,22	21,22	NOUN
admet-1513	72	3	]	]	X
admet-1513	72	4	.	.	PUNCT
admet-1513	73	1	cell	cell	NOUN
admet-1513	73	2	line	line	NOUN
admet-1513	73	3	models	model	NOUN
admet-1513	73	4	caco-2	caco-2	NUM
admet-1513	73	5	(	(	PUNCT
admet-1513	73	6	human	human	ADJ
admet-1513	73	7	colon	colon	NOUN
admet-1513	73	8	adenocarcinoma	adenocarcinoma	NOUN
admet-1513	73	9	)	)	PUNCT
admet-1513	73	10	the	the	DET
admet-1513	73	11	most	most	ADV
admet-1513	73	12	commonly	commonly	ADV
admet-1513	73	13	used	use	VERB
admet-1513	73	14	cell	cell	NOUN
admet-1513	73	15	line	line	NOUN
admet-1513	73	16	model	model	NOUN
admet-1513	73	17	for	for	ADP
admet-1513	73	18	studying	study	VERB
admet-1513	73	19	the	the	DET
admet-1513	73	20	mechanism	mechanism	NOUN
admet-1513	73	21	of	of	ADP
admet-1513	73	22	intestinal	intestinal	ADJ
admet-1513	73	23	absorption	absorption	NOUN
admet-1513	73	24	is	be	AUX
admet-1513	73	25	caco-2	caco-2	NOUN
admet-1513	73	26	,	,	PUNCT
admet-1513	73	27	derived	derive	VERB
admet-1513	73	28	from	from	ADP
admet-1513	73	29	human	human	ADJ
admet-1513	73	30	colon	colon	NOUN
admet-1513	73	31	adenocarcinoma	adenocarcinoma	NOUN
admet-1513	73	32	.	.	PUNCT
admet-1513	74	1	they	they	PRON
admet-1513	74	2	are	be	AUX
admet-1513	74	3	characterized	characterize	VERB
admet-1513	74	4	by	by	ADP
admet-1513	74	5	enterocytic	enterocytic	ADJ
admet-1513	74	6	phenotype	phenotype	NOUN
admet-1513	74	7	having	have	VERB
admet-1513	74	8	villi	villi	NOUN
admet-1513	74	9	and	and	CCONJ
admet-1513	74	10	microvilli	microvilli	NOUN
admet-1513	74	11	as	as	ADV
admet-1513	74	12	well	well	ADV
admet-1513	74	13	as	as	ADP
admet-1513	74	14	tight	tight	ADJ
admet-1513	74	15	junctions	junction	NOUN
admet-1513	74	16	after	after	ADP
admet-1513	74	17	reaching	reach	VERB
admet-1513	74	18	full	full	ADJ
admet-1513	74	19	confluence	confluence	NOUN
admet-1513	74	20	[	[	X
admet-1513	74	21	23	23	NUM
admet-1513	74	22	]	]	PUNCT
admet-1513	74	23	.	.	PUNCT
admet-1513	75	1	the	the	DET
admet-1513	75	2	regulatory	regulatory	ADJ
admet-1513	75	3	authority	authority	NOUN
admet-1513	75	4	for	for	ADP
admet-1513	75	5	admehttps://doi.org/10.5599/admet.1513	admehttps://doi.org/10.5599/admet.1513	DET
admet-1513	75	6	venkatesh	venkatesh	PROPN
admet-1513	75	7	chunduri	chunduri	PROPN
admet-1513	75	8	and	and	CCONJ
admet-1513	75	9	srinivas	srinivas	PROPN
admet-1513	75	10	maddi	maddi	PROPN
admet-1513	75	11	admet	admet	PROPN
admet-1513	75	12	&	&	CCONJ
admet-1513	75	13	dmpk	dmpk	PROPN
admet-1513	75	14	11(1	11(1	NUM
admet-1513	75	15	)	)	PUNCT
admet-1513	75	16	(	(	PUNCT
admet-1513	75	17	2023	2023	NUM
admet-1513	75	18	)	)	PUNCT
admet-1513	75	19	1	1	NUM
admet-1513	75	20	-	-	SYM
admet-1513	75	21	32	32	NUM
admet-1513	75	22	4	4	NUM
admet-1513	75	23	tox	tox	NOUN
admet-1513	75	24	studies	study	NOUN
admet-1513	75	25	considers	consider	VERB
admet-1513	75	26	this	this	DET
admet-1513	75	27	model	model	NOUN
admet-1513	75	28	the	the	DET
admet-1513	75	29	gold	gold	ADJ
admet-1513	75	30	standard	standard	NOUN
admet-1513	75	31	as	as	SCONJ
admet-1513	75	32	it	it	PRON
admet-1513	75	33	provides	provide	VERB
admet-1513	75	34	absorbed	absorb	VERB
admet-1513	75	35	and	and	CCONJ
admet-1513	75	36	metabolized	metabolize	VERB
admet-1513	75	37	fractions	fraction	NOUN
admet-1513	75	38	of	of	ADP
admet-1513	75	39	compounds	compound	NOUN
admet-1513	75	40	across	across	ADP
admet-1513	75	41	the	the	DET
admet-1513	75	42	intestinal	intestinal	ADJ
admet-1513	75	43	epithelium	epithelium	NOUN
admet-1513	76	1	[	[	X
admet-1513	76	2	24	24	NUM
admet-1513	76	3	]	]	PUNCT
admet-1513	76	4	.	.	PUNCT
admet-1513	77	1	indeed	indeed	ADV
admet-1513	77	2	,	,	PUNCT
admet-1513	77	3	the	the	DET
admet-1513	77	4	food	food	NOUN
admet-1513	77	5	and	and	CCONJ
admet-1513	77	6	drug	drug	PROPN
admet-1513	77	7	administration	administration	PROPN
admet-1513	77	8	(	(	PUNCT
admet-1513	77	9	fda	fda	PROPN
admet-1513	77	10	)	)	PUNCT
admet-1513	77	11	recognized	recognize	VERB
admet-1513	77	12	the	the	DET
admet-1513	77	13	caco-2	caco-2	NUM
admet-1513	77	14	model	model	NOUN
admet-1513	77	15	system	system	NOUN
admet-1513	77	16	as	as	ADP
admet-1513	77	17	useful	useful	ADJ
admet-1513	77	18	in	in	ADP
admet-1513	77	19	classifying	classify	VERB
admet-1513	77	20	a	a	DET
admet-1513	77	21	compound	compound	NOUN
admet-1513	77	22	’s	’s	PART
admet-1513	77	23	absorption	absorption	NOUN
admet-1513	77	24	characteristics	characteristic	NOUN
admet-1513	77	25	in	in	ADP
admet-1513	77	26	the	the	DET
admet-1513	77	27	biopharmaceutics	biopharmaceutics	NOUN
admet-1513	77	28	classification	classification	NOUN
admet-1513	77	29	system	system	NOUN
admet-1513	77	30	[	[	X
admet-1513	77	31	25	25	NUM
admet-1513	77	32	]	]	PUNCT
admet-1513	77	33	.	.	PUNCT
admet-1513	78	1	the	the	DET
admet-1513	78	2	caco-2	caco-2	NUM
admet-1513	78	3	cell	cell	NOUN
admet-1513	78	4	line	line	NOUN
admet-1513	78	5	model	model	NOUN
admet-1513	78	6	is	be	AUX
admet-1513	78	7	considered	consider	VERB
admet-1513	78	8	efficient	efficient	ADJ
admet-1513	78	9	for	for	ADP
admet-1513	78	10	studying	study	VERB
admet-1513	78	11	the	the	DET
admet-1513	78	12	passive	passive	ADJ
admet-1513	78	13	diffusion	diffusion	NOUN
admet-1513	78	14	of	of	ADP
admet-1513	78	15	lipophilic	lipophilic	ADJ
admet-1513	78	16	compounds	compound	NOUN
admet-1513	78	17	due	due	ADP
admet-1513	78	18	to	to	ADP
admet-1513	78	19	its	its	PRON
admet-1513	78	20	absorptive	absorptive	ADJ
admet-1513	78	21	similarity	similarity	NOUN
admet-1513	78	22	with	with	ADP
admet-1513	78	23	intestinal	intestinal	ADJ
admet-1513	78	24	enterocytes	enterocyte	NOUN
admet-1513	78	25	[	[	X
admet-1513	78	26	26	26	NUM
admet-1513	78	27	]	]	PUNCT
admet-1513	78	28	.	.	PUNCT
admet-1513	79	1	reports	report	NOUN
admet-1513	79	2	also	also	ADV
admet-1513	79	3	suggest	suggest	VERB
admet-1513	79	4	that	that	SCONJ
admet-1513	79	5	the	the	DET
admet-1513	79	6	permeability	permeability	NOUN
admet-1513	79	7	coefficient	coefficient	NOUN
admet-1513	79	8	of	of	ADP
admet-1513	79	9	the	the	DET
admet-1513	79	10	caco-2	caco-2	NUM
admet-1513	79	11	model	model	NOUN
admet-1513	79	12	is	be	AUX
admet-1513	79	13	correlated	correlate	VERB
admet-1513	79	14	with	with	ADP
admet-1513	79	15	in	in	ADP
admet-1513	79	16	vivo	vivo	ADJ
admet-1513	79	17	fraction	fraction	NOUN
admet-1513	79	18	absorbed	absorb	VERB
admet-1513	79	19	[	[	PUNCT
admet-1513	79	20	27	27	NUM
admet-1513	79	21	]	]	PUNCT
admet-1513	79	22	.	.	PUNCT
admet-1513	80	1	although	although	SCONJ
admet-1513	80	2	caco-2	caco-2	NUM
admet-1513	80	3	is	be	AUX
admet-1513	80	4	considered	consider	VERB
admet-1513	80	5	a	a	DET
admet-1513	80	6	valuable	valuable	ADJ
admet-1513	80	7	tool	tool	NOUN
admet-1513	80	8	for	for	ADP
admet-1513	80	9	screening	screen	VERB
admet-1513	80	10	passively	passively	ADV
admet-1513	80	11	transported	transport	VERB
admet-1513	80	12	drugs	drug	NOUN
admet-1513	80	13	,	,	PUNCT
admet-1513	80	14	limitations	limitation	NOUN
admet-1513	80	15	were	be	AUX
admet-1513	80	16	observed	observe	VERB
admet-1513	80	17	when	when	SCONJ
admet-1513	80	18	we	we	PRON
admet-1513	80	19	use	use	VERB
admet-1513	80	20	the	the	DET
admet-1513	80	21	model	model	NOUN
admet-1513	80	22	for	for	ADP
admet-1513	80	23	active	active	ADJ
admet-1513	80	24	transport	transport	NOUN
admet-1513	80	25	due	due	ADP
admet-1513	80	26	to	to	ADP
admet-1513	80	27	the	the	DET
admet-1513	80	28	absence	absence	NOUN
admet-1513	80	29	of	of	ADP
admet-1513	80	30	p	p	NOUN
admet-1513	80	31	-	-	PUNCT
admet-1513	80	32	glycoproteins	glycoprotein	NOUN
admet-1513	80	33	(	(	PUNCT
admet-1513	80	34	p	p	NOUN
admet-1513	80	35	-	-	PUNCT
admet-1513	80	36	gp	gp	NOUN
admet-1513	80	37	)	)	PUNCT
admet-1513	81	1	[	[	X
admet-1513	81	2	28	28	NUM
admet-1513	81	3	]	]	PUNCT
admet-1513	81	4	and	and	CCONJ
admet-1513	81	5	multi	multi	ADJ
admet-1513	81	6	-	-	ADJ
admet-1513	81	7	drug	drug	ADJ
admet-1513	81	8	resistant	resistant	ADJ
admet-1513	81	9	(	(	PUNCT
admet-1513	81	10	mdr	mdr	NOUN
admet-1513	81	11	)	)	PUNCT
admet-1513	81	12	proteins	protein	NOUN
admet-1513	81	13	[	[	X
admet-1513	81	14	29	29	NUM
admet-1513	81	15	]	]	PUNCT
admet-1513	81	16	.	.	PUNCT
admet-1513	82	1	moreover	moreover	ADV
admet-1513	82	2	,	,	PUNCT
admet-1513	82	3	deficiency	deficiency	NOUN
admet-1513	82	4	of	of	ADP
admet-1513	82	5	some	some	PRON
admet-1513	82	6	of	of	ADP
admet-1513	82	7	the	the	DET
admet-1513	82	8	metabolizing	metabolize	VERB
admet-1513	82	9	enzymes	enzyme	NOUN
admet-1513	82	10	such	such	ADJ
admet-1513	82	11	as	as	ADP
admet-1513	82	12	cytochrome	cytochrome	NOUN
admet-1513	82	13	p450	p450	PROPN
admet-1513	82	14	3a4	3a4	NUM
admet-1513	82	15	(	(	PUNCT
admet-1513	82	16	cyp3a4	cyp3a4	PROPN
admet-1513	82	17	)	)	PUNCT
admet-1513	82	18	,	,	PUNCT
admet-1513	82	19	absence	absence	NOUN
admet-1513	82	20	of	of	ADP
admet-1513	82	21	mucous	mucous	ADJ
admet-1513	82	22	layer	layer	NOUN
admet-1513	82	23	and	and	CCONJ
admet-1513	82	24	slow	slow	ADJ
admet-1513	82	25	growth	growth	NOUN
admet-1513	82	26	are	be	AUX
admet-1513	82	27	also	also	ADV
admet-1513	82	28	major	major	ADJ
admet-1513	82	29	drawbacks	drawback	NOUN
admet-1513	82	30	and	and	CCONJ
admet-1513	82	31	significantly	significantly	ADV
admet-1513	82	32	impact	impact	VERB
admet-1513	82	33	model	model	NOUN
admet-1513	82	34	accuracy	accuracy	NOUN
admet-1513	82	35	[	[	X
admet-1513	82	36	30	30	NUM
admet-1513	82	37	-	-	SYM
admet-1513	82	38	32	32	NUM
admet-1513	82	39	]	]	PUNCT
admet-1513	82	40	.	.	PUNCT
admet-1513	83	1	in	in	ADP
admet-1513	83	2	addition	addition	NOUN
admet-1513	83	3	,	,	PUNCT
admet-1513	83	4	the	the	DET
admet-1513	83	5	transmembrane	transmembrane	NOUN
admet-1513	83	6	resistance	resistance	NOUN
admet-1513	83	7	(	(	PUNCT
admet-1513	83	8	teer	teer	PROPN
admet-1513	83	9	)	)	PUNCT
admet-1513	83	10	is	be	AUX
admet-1513	83	11	also	also	ADV
admet-1513	83	12	higher	high	ADJ
admet-1513	83	13	(	(	PUNCT
admet-1513	83	14	250	250	NUM
admet-1513	83	15	-	-	SYM
admet-1513	83	16	2500	2500	NUM
admet-1513	83	17	ω⋅cm2	ω⋅cm2	NOUN
admet-1513	83	18	)	)	PUNCT
admet-1513	83	19	as	as	SCONJ
admet-1513	83	20	compared	compare	VERB
admet-1513	83	21	to	to	ADP
admet-1513	83	22	the	the	DET
admet-1513	83	23	small	small	ADJ
admet-1513	83	24	intestine	intestine	NOUN
admet-1513	83	25	(	(	PUNCT
admet-1513	83	26	12	12	NUM
admet-1513	83	27	-	-	SYM
admet-1513	83	28	120	120	NUM
admet-1513	83	29	ω⋅cm2	ω⋅cm2	NOUN
admet-1513	83	30	)	)	PUNCT
admet-1513	84	1	[	[	X
admet-1513	84	2	33	33	NUM
admet-1513	84	3	]	]	PUNCT
admet-1513	84	4	.	.	PUNCT
admet-1513	85	1	tc7	tc7	NOUN
admet-1513	85	2	(	(	PUNCT
admet-1513	85	3	cac-2	cac-2	X
admet-1513	85	4	clone	clone	NOUN
admet-1513	85	5	)	)	PUNCT
admet-1513	85	6	to	to	PART
admet-1513	85	7	overcome	overcome	VERB
admet-1513	85	8	some	some	PRON
admet-1513	85	9	of	of	ADP
admet-1513	85	10	the	the	DET
admet-1513	85	11	major	major	ADJ
admet-1513	85	12	limitations	limitation	NOUN
admet-1513	85	13	of	of	ADP
admet-1513	85	14	the	the	DET
admet-1513	85	15	caco-2	caco-2	NUM
admet-1513	85	16	model	model	NOUN
admet-1513	85	17	,	,	PUNCT
admet-1513	85	18	researchers	researcher	NOUN
admet-1513	85	19	have	have	AUX
admet-1513	85	20	derived	derive	VERB
admet-1513	85	21	a	a	DET
admet-1513	85	22	tc7	tc7	NOUN
admet-1513	85	23	cell	cell	NOUN
admet-1513	85	24	line	line	NOUN
admet-1513	85	25	,	,	PUNCT
admet-1513	85	26	which	which	PRON
admet-1513	85	27	is	be	AUX
admet-1513	85	28	isolated	isolate	VERB
admet-1513	85	29	from	from	ADP
admet-1513	85	30	caco-2	caco-2	NUM
admet-1513	85	31	subclones	subclone	NOUN
admet-1513	85	32	.	.	PUNCT
admet-1513	86	1	some	some	DET
admet-1513	86	2	major	major	ADJ
admet-1513	86	3	advantages	advantage	NOUN
admet-1513	86	4	of	of	ADP
admet-1513	86	5	tc7	tc7	NOUN
admet-1513	86	6	include	include	VERB
admet-1513	86	7	faster	fast	ADJ
admet-1513	86	8	growth	growth	NOUN
admet-1513	86	9	,	,	PUNCT
admet-1513	86	10	relatively	relatively	ADV
admet-1513	86	11	lower	low	ADJ
admet-1513	86	12	teer	teer	NOUN
admet-1513	86	13	(	(	PUNCT
admet-1513	86	14	150	150	NUM
admet-1513	86	15	-	-	SYM
admet-1513	86	16	750	750	NUM
admet-1513	86	17	ω⋅cm2	ω⋅cm2	NOUN
admet-1513	86	18	)	)	PUNCT
admet-1513	86	19	and	and	CCONJ
admet-1513	86	20	less	less	ADJ
admet-1513	86	21	heterogeneity	heterogeneity	NOUN
admet-1513	86	22	[	[	X
admet-1513	86	23	34	34	NUM
admet-1513	86	24	]	]	PUNCT
admet-1513	86	25	.	.	PUNCT
admet-1513	87	1	moreover	moreover	ADV
admet-1513	87	2	,	,	PUNCT
admet-1513	87	3	the	the	DET
admet-1513	87	4	number	number	NOUN
admet-1513	87	5	of	of	ADP
admet-1513	87	6	metabolic	metabolic	NOUN
admet-1513	87	7	enzymes	enzyme	NOUN
admet-1513	87	8	at	at	ADP
admet-1513	87	9	high	high	ADJ
admet-1513	87	10	confluencies	confluencie	NOUN
admet-1513	87	11	,	,	PUNCT
admet-1513	87	12	such	such	ADJ
admet-1513	87	13	as	as	ADP
admet-1513	87	14	udp	udp	NOUN
admet-1513	87	15	-	-	NOUN
admet-1513	87	16	glucuronosyl	glucuronosyl	ADJ
admet-1513	87	17	transferases	transferase	NOUN
admet-1513	87	18	,	,	PUNCT
admet-1513	87	19	hydrolase	hydrolase	NOUN
admet-1513	87	20	,	,	PUNCT
admet-1513	87	21	sucrase	sucrase	NOUN
admet-1513	87	22	-	-	PUNCT
admet-1513	87	23	isomaltase	isomaltase	PROPN
admet-1513	87	24	and	and	CCONJ
admet-1513	87	25	cyp3a	cyp3a	NOUN
admet-1513	87	26	isoenzymes	isoenzyme	NOUN
admet-1513	87	27	,	,	PUNCT
admet-1513	87	28	are	be	AUX
admet-1513	87	29	also	also	ADV
admet-1513	87	30	similar	similar	ADJ
admet-1513	87	31	to	to	ADP
admet-1513	87	32	that	that	PRON
admet-1513	87	33	of	of	ADP
admet-1513	87	34	the	the	DET
admet-1513	87	35	intestinal	intestinal	ADJ
admet-1513	87	36	epithelium	epithelium	NOUN
admet-1513	87	37	of	of	ADP
admet-1513	87	38	the	the	DET
admet-1513	87	39	duodenum	duodenum	NOUN
admet-1513	87	40	and	and	CCONJ
admet-1513	87	41	jejunum	jejunum	ADJ
admet-1513	88	1	[	[	X
admet-1513	88	2	35	35	NUM
admet-1513	88	3	]	]	PUNCT
admet-1513	88	4	.	.	PUNCT
admet-1513	89	1	in	in	ADP
admet-1513	89	2	addition	addition	NOUN
admet-1513	89	3	,	,	PUNCT
admet-1513	89	4	the	the	DET
admet-1513	89	5	transcellular	transcellular	NOUN
admet-1513	89	6	drug	drug	NOUN
admet-1513	89	7	kinetics	kinetic	NOUN
admet-1513	89	8	correlate	correlate	VERB
admet-1513	89	9	with	with	ADP
admet-1513	89	10	caco-2	caco-2	NUM
admet-1513	89	11	,	,	PUNCT
admet-1513	89	12	indicating	indicate	VERB
admet-1513	89	13	tc7	tc7	NOUN
admet-1513	89	14	can	can	AUX
admet-1513	89	15	be	be	AUX
admet-1513	89	16	an	an	DET
admet-1513	89	17	excellent	excellent	ADJ
admet-1513	89	18	option	option	NOUN
admet-1513	89	19	over	over	ADP
admet-1513	89	20	caco-2	caco-2	PROPN
admet-1513	89	21	[	[	X
admet-1513	89	22	36,37	36,37	NUM
admet-1513	89	23	]	]	X
admet-1513	89	24	.	.	PUNCT
admet-1513	90	1	still	still	ADV
admet-1513	90	2	,	,	PUNCT
admet-1513	90	3	further	further	ADJ
admet-1513	90	4	investigations	investigation	NOUN
admet-1513	90	5	are	be	AUX
admet-1513	90	6	required	require	VERB
admet-1513	90	7	for	for	ADP
admet-1513	90	8	large	large	ADJ
admet-1513	90	9	-	-	PUNCT
admet-1513	90	10	scale	scale	NOUN
admet-1513	90	11	evaluation	evaluation	NOUN
admet-1513	90	12	to	to	PART
admet-1513	90	13	check	check	VERB
admet-1513	90	14	the	the	DET
admet-1513	90	15	potential	potential	NOUN
admet-1513	90	16	of	of	ADP
admet-1513	90	17	the	the	DET
admet-1513	90	18	tc7	tc7	NOUN
admet-1513	90	19	model	model	NOUN
admet-1513	90	20	.	.	PUNCT
admet-1513	91	1	mdck	mdck	PROPN
admet-1513	91	2	(	(	PUNCT
admet-1513	91	3	madin	madin	PROPN
admet-1513	91	4	-	-	PUNCT
admet-1513	91	5	darby	darby	PROPN
admet-1513	91	6	canine	canine	PROPN
admet-1513	91	7	kidney	kidney	PROPN
admet-1513	91	8	)	)	PUNCT
admet-1513	91	9	(	(	PUNCT
admet-1513	91	10	mdck	mdck	PROPN
admet-1513	91	11	is	be	AUX
admet-1513	91	12	another	another	DET
admet-1513	91	13	cell	cell	NOUN
admet-1513	91	14	line	line	NOUN
admet-1513	91	15	that	that	PRON
admet-1513	91	16	can	can	AUX
admet-1513	91	17	be	be	AUX
admet-1513	91	18	used	use	VERB
admet-1513	91	19	for	for	ADP
admet-1513	91	20	permeability	permeability	NOUN
admet-1513	91	21	studies	study	NOUN
admet-1513	91	22	for	for	ADP
admet-1513	91	23	its	its	PRON
admet-1513	91	24	similarity	similarity	NOUN
admet-1513	91	25	with	with	ADP
admet-1513	91	26	caco-2	caco-2	NUM
admet-1513	91	27	morphology	morphology	NOUN
admet-1513	91	28	consisting	consist	VERB
admet-1513	91	29	of	of	ADP
admet-1513	91	30	brush	brush	NOUN
admet-1513	91	31	border	border	NOUN
admet-1513	91	32	and	and	CCONJ
admet-1513	91	33	tight	tight	ADJ
admet-1513	91	34	junctions	junction	NOUN
admet-1513	91	35	[	[	X
admet-1513	91	36	23	23	NUM
admet-1513	91	37	]	]	PUNCT
admet-1513	91	38	.	.	PUNCT
admet-1513	92	1	the	the	DET
admet-1513	92	2	major	major	ADJ
admet-1513	92	3	advantages	advantage	NOUN
admet-1513	92	4	are	be	AUX
admet-1513	92	5	also	also	ADV
admet-1513	92	6	lower	low	ADJ
admet-1513	92	7	teer	teer	NOUN
admet-1513	92	8	(	(	PUNCT
admet-1513	92	9	173	173	NUM
admet-1513	92	10	ω⋅cm2	ω⋅cm2	NOUN
admet-1513	92	11	)	)	PUNCT
admet-1513	92	12	and	and	CCONJ
admet-1513	92	13	less	less	ADJ
admet-1513	92	14	growth	growth	NOUN
admet-1513	92	15	period	period	NOUN
admet-1513	92	16	(	(	PUNCT
admet-1513	92	17	3	3	NUM
admet-1513	92	18	-	-	SYM
admet-1513	92	19	5	5	NUM
admet-1513	92	20	days	day	NOUN
admet-1513	92	21	for	for	ADP
admet-1513	92	22	full	full	ADJ
admet-1513	92	23	confluency	confluency	NOUN
admet-1513	92	24	)	)	PUNCT
admet-1513	92	25	,	,	PUNCT
admet-1513	92	26	and	and	CCONJ
admet-1513	92	27	subsequently	subsequently	ADV
admet-1513	92	28	,	,	PUNCT
admet-1513	92	29	less	less	ADJ
admet-1513	92	30	cost	cost	NOUN
admet-1513	92	31	[	[	X
admet-1513	92	32	38	38	NUM
admet-1513	92	33	]	]	PUNCT
admet-1513	92	34	.	.	PUNCT
admet-1513	93	1	thus	thus	ADV
admet-1513	93	2	,	,	PUNCT
admet-1513	93	3	the	the	DET
admet-1513	93	4	mdck	mdck	PROPN
admet-1513	93	5	model	model	NOUN
admet-1513	93	6	can	can	AUX
admet-1513	93	7	be	be	AUX
admet-1513	93	8	used	use	VERB
admet-1513	93	9	for	for	ADP
admet-1513	93	10	studying	study	VERB
admet-1513	93	11	the	the	DET
admet-1513	93	12	permeability	permeability	NOUN
admet-1513	93	13	screening	screening	NOUN
admet-1513	93	14	of	of	ADP
admet-1513	93	15	both	both	CCONJ
admet-1513	93	16	intestinal	intestinal	ADJ
admet-1513	93	17	and	and	CCONJ
admet-1513	93	18	renal	renal	ADJ
admet-1513	93	19	epithelia	epithelium	NOUN
admet-1513	93	20	in	in	ADP
admet-1513	93	21	the	the	DET
admet-1513	93	22	drug	drug	NOUN
admet-1513	93	23	discovery	discovery	NOUN
admet-1513	93	24	process	process	NOUN
admet-1513	93	25	[	[	X
admet-1513	93	26	38	38	NUM
admet-1513	93	27	]	]	PUNCT
admet-1513	93	28	.	.	PUNCT
admet-1513	94	1	still	still	ADV
admet-1513	94	2	,	,	PUNCT
admet-1513	94	3	there	there	PRON
admet-1513	94	4	are	be	VERB
admet-1513	94	5	some	some	DET
admet-1513	94	6	major	major	ADJ
admet-1513	94	7	limitations	limitation	NOUN
admet-1513	94	8	present	present	ADJ
admet-1513	94	9	in	in	ADP
admet-1513	94	10	this	this	DET
admet-1513	94	11	model	model	NOUN
admet-1513	94	12	,	,	PUNCT
admet-1513	94	13	which	which	PRON
admet-1513	94	14	include	include	VERB
admet-1513	94	15	:	:	PUNCT
admet-1513	94	16	1	1	X
admet-1513	94	17	.	.	X
admet-1513	94	18	intolerance	intolerance	NOUN
admet-1513	94	19	to	to	ADP
admet-1513	94	20	organic	organic	ADJ
admet-1513	94	21	solvent	solvent	NOUN
admet-1513	94	22	,	,	PUNCT
admet-1513	94	23	leading	lead	VERB
admet-1513	94	24	to	to	ADP
admet-1513	94	25	less	less	ADJ
admet-1513	94	26	access	access	NOUN
admet-1513	94	27	to	to	ADP
admet-1513	94	28	high	high	ADJ
admet-1513	94	29	lipophilic	lipophilic	ADJ
admet-1513	94	30	compounds	compound	NOUN
admet-1513	94	31	;	;	PUNCT
admet-1513	94	32	2	2	X
admet-1513	94	33	.	.	X
admet-1513	94	34	non	non	ADJ
admet-1513	94	35	-	-	ADJ
admet-1513	94	36	intestinal	intestinal	ADJ
admet-1513	94	37	origin	origin	NOUN
admet-1513	94	38	and	and	CCONJ
admet-1513	94	39	less	less	ADJ
admet-1513	94	40	homogenecity	homogenecity	NOUN
admet-1513	94	41	;	;	PUNCT
admet-1513	94	42	3	3	X
admet-1513	94	43	.	.	NOUN
admet-1513	94	44	lack	lack	NOUN
admet-1513	94	45	of	of	ADP
admet-1513	94	46	transporters	transporter	NOUN
admet-1513	94	47	and	and	CCONJ
admet-1513	94	48	metabolic	metabolic	NOUN
admet-1513	94	49	enzymes	enzyme	NOUN
admet-1513	94	50	[	[	X
admet-1513	94	51	39	39	NUM
admet-1513	94	52	]	]	PUNCT
admet-1513	94	53	.	.	PUNCT
admet-1513	95	1	to	to	PART
admet-1513	95	2	overcome	overcome	VERB
admet-1513	95	3	this	this	PRON
admet-1513	95	4	,	,	PUNCT
admet-1513	95	5	researchers	researcher	NOUN
admet-1513	95	6	have	have	AUX
admet-1513	95	7	transferred	transfer	VERB
admet-1513	95	8	the	the	DET
admet-1513	95	9	mdr1	mdr1	PROPN
admet-1513	95	10	gene	gene	NOUN
admet-1513	95	11	to	to	PART
admet-1513	95	12	induce	induce	VERB
admet-1513	95	13	its	its	PRON
admet-1513	95	14	expression	expression	NOUN
admet-1513	95	15	and	and	CCONJ
admet-1513	95	16	observed	observed	ADJ
admet-1513	95	17	overexpression	overexpression	NOUN
admet-1513	95	18	of	of	ADP
admet-1513	95	19	p	p	NOUN
admet-1513	95	20	-	-	PUNCT
admet-1513	95	21	gps	gps	PROPN
admet-1513	95	22	and	and	CCONJ
admet-1513	95	23	increased	increase	VERB
admet-1513	95	24	digoxin	digoxin	NOUN
admet-1513	95	25	efflux	efflux	NOUN
admet-1513	95	26	compared	compare	VERB
admet-1513	95	27	to	to	ADP
admet-1513	95	28	its	its	PRON
admet-1513	95	29	parent	parent	NOUN
admet-1513	95	30	mdck	mdck	ADJ
admet-1513	95	31	cell	cell	NOUN
admet-1513	95	32	line	line	NOUN
admet-1513	96	1	[	[	X
admet-1513	96	2	40	40	NUM
admet-1513	96	3	]	]	PUNCT
admet-1513	96	4	.	.	PUNCT
admet-1513	97	1	however	however	ADV
admet-1513	97	2	,	,	PUNCT
admet-1513	97	3	in	in	ADP
admet-1513	97	4	comparison	comparison	NOUN
admet-1513	97	5	with	with	ADP
admet-1513	97	6	caco-2	caco-2	NUM
admet-1513	97	7	,	,	PUNCT
admet-1513	97	8	the	the	DET
admet-1513	97	9	mdck	mdck	PROPN
admet-1513	97	10	model	model	NOUN
admet-1513	97	11	remains	remain	VERB
admet-1513	97	12	less	less	ADV
admet-1513	97	13	applicable	applicable	ADJ
admet-1513	97	14	[	[	X
admet-1513	97	15	41	41	NUM
admet-1513	97	16	]	]	PUNCT
admet-1513	97	17	.	.	PUNCT
admet-1513	98	1	ht-29	ht-29	PROPN
admet-1513	98	2	(	(	PUNCT
admet-1513	98	3	human	human	ADJ
admet-1513	98	4	colorectal	colorectal	ADJ
admet-1513	98	5	adenocarcinoma	adenocarcinoma	NOUN
admet-1513	98	6	cell	cell	NOUN
admet-1513	98	7	line	line	NOUN
admet-1513	98	8	)	)	PUNCT
admet-1513	98	9	ht-29	ht-29	PUNCT
admet-1513	98	10	is	be	AUX
admet-1513	98	11	another	another	DET
admet-1513	98	12	cell	cell	NOUN
admet-1513	98	13	line	line	NOUN
admet-1513	98	14	used	use	VERB
admet-1513	98	15	for	for	ADP
admet-1513	98	16	studying	study	VERB
admet-1513	98	17	drug	drug	NOUN
admet-1513	98	18	permeability	permeability	NOUN
admet-1513	98	19	by	by	ADP
admet-1513	98	20	researchers	researcher	NOUN
admet-1513	98	21	.	.	PUNCT
admet-1513	99	1	they	they	PRON
admet-1513	99	2	are	be	AUX
admet-1513	99	3	derived	derive	VERB
admet-1513	99	4	from	from	ADP
admet-1513	99	5	human	human	ADJ
admet-1513	99	6	colon	colon	NOUN
admet-1513	99	7	adenocarcinoma	adenocarcinoma	NOUN
admet-1513	99	8	cells	cell	NOUN
admet-1513	99	9	having	have	VERB
admet-1513	99	10	characteristics	characteristic	NOUN
admet-1513	99	11	similar	similar	ADJ
admet-1513	99	12	to	to	PART
admet-1513	99	13	mature	mature	VERB
admet-1513	99	14	intestinal	intestinal	ADJ
admet-1513	99	15	cells	cell	NOUN
admet-1513	99	16	,	,	PUNCT
admet-1513	99	17	like	like	ADP
admet-1513	99	18	absorptive	absorptive	ADJ
admet-1513	99	19	enterocytes	enterocyte	NOUN
admet-1513	99	20	and	and	CCONJ
admet-1513	99	21	intestinal	intestinal	ADJ
admet-1513	99	22	secretory	secretory	ADJ
admet-1513	99	23	cells	cell	NOUN
admet-1513	99	24	that	that	PRON
admet-1513	99	25	secrete	secrete	VERB
admet-1513	99	26	mucous	mucous	ADJ
admet-1513	99	27	[	[	X
admet-1513	99	28	42	42	NUM
admet-1513	99	29	]	]	PUNCT
admet-1513	99	30	.	.	PUNCT
admet-1513	100	1	however	however	ADV
admet-1513	100	2	,	,	PUNCT
admet-1513	100	3	the	the	DET
admet-1513	100	4	differentiation	differentiation	NOUN
admet-1513	100	5	of	of	ADP
admet-1513	100	6	ht-29	ht-29	PUNCT
admet-1513	100	7	cells	cell	NOUN
admet-1513	100	8	is	be	AUX
admet-1513	100	9	dependent	dependent	ADJ
admet-1513	100	10	on	on	ADP
admet-1513	100	11	external	external	ADJ
admet-1513	100	12	media	medium	NOUN
admet-1513	100	13	composition	composition	NOUN
admet-1513	100	14	.	.	PUNCT
admet-1513	101	1	under	under	ADP
admet-1513	101	2	the	the	DET
admet-1513	101	3	glucose	glucose	NOUN
admet-1513	101	4	-	-	PUNCT
admet-1513	101	5	free	free	ADJ
admet-1513	101	6	condition	condition	NOUN
admet-1513	101	7	,	,	PUNCT
admet-1513	101	8	the	the	DET
admet-1513	101	9	ht-29	ht-29	PUNCT
admet-1513	101	10	cells	cell	NOUN
admet-1513	101	11	have	have	VERB
admet-1513	101	12	characteristic	characteristic	ADJ
admet-1513	101	13	similarities	similarity	NOUN
admet-1513	101	14	with	with	ADP
admet-1513	101	15	intestinal	intestinal	ADJ
admet-1513	101	16	epithelium	epithelium	NOUN
admet-1513	101	17	like	like	ADP
admet-1513	101	18	villi	villi	NOUN
admet-1513	101	19	and	and	CCONJ
admet-1513	101	20	micro	micro	NOUN
admet-1513	101	21	-	-	NOUN
admet-1513	101	22	villi	villi	ADJ
admet-1513	101	23	,	,	PUNCT
admet-1513	101	24	tight	tight	ADJ
admet-1513	101	25	junctions	junction	NOUN
admet-1513	101	26	and	and	CCONJ
admet-1513	101	27	metabolic	metabolic	NOUN
admet-1513	101	28	enzymes	enzyme	NOUN
admet-1513	101	29	associated	associate	VERB
admet-1513	101	30	with	with	ADP
admet-1513	101	31	micro	micro	NOUN
admet-1513	101	32	-	-	NOUN
admet-1513	101	33	villi	villi	NOUN
admet-1513	101	34	[	[	X
admet-1513	101	35	43	43	NUM
admet-1513	101	36	]	]	PUNCT
admet-1513	101	37	.	.	PUNCT
admet-1513	102	1	although	although	SCONJ
admet-1513	102	2	ht-29	ht-29	VERB
admet-1513	102	3	has	have	VERB
admet-1513	102	4	characteristic	characteristic	ADJ
admet-1513	102	5	similarity	similarity	NOUN
admet-1513	102	6	,	,	PUNCT
admet-1513	102	7	it	it	PRON
admet-1513	102	8	is	be	AUX
admet-1513	102	9	less	less	ADV
admet-1513	102	10	utilized	utilize	VERB
admet-1513	102	11	due	due	ADP
admet-1513	102	12	to	to	ADP
admet-1513	102	13	the	the	DET
admet-1513	102	14	expression	expression	NOUN
admet-1513	102	15	of	of	ADP
admet-1513	102	16	hydrolases	hydrolase	NOUN
admet-1513	102	17	on	on	ADP
admet-1513	102	18	the	the	DET
admet-1513	102	19	apical	apical	ADJ
admet-1513	102	20	side	side	NOUN
admet-1513	102	21	and	and	CCONJ
admet-1513	102	22	also	also	ADV
admet-1513	102	23	the	the	DET
admet-1513	102	24	presence	presence	NOUN
admet-1513	102	25	of	of	ADP
admet-1513	102	26	several	several	ADJ
admet-1513	102	27	membrane	membrane	NOUN
admet-1513	102	28	receptors	receptor	NOUN
admet-1513	102	29	that	that	PRON
admet-1513	102	30	are	be	AUX
admet-1513	102	31	usually	usually	ADV
admet-1513	102	32	absent	absent	ADJ
admet-1513	102	33	in	in	ADP
admet-1513	102	34	the	the	DET
admet-1513	102	35	human	human	ADJ
admet-1513	102	36	intestinal	intestinal	ADJ
admet-1513	102	37	epithelium	epithelium	NOUN
admet-1513	102	38	.	.	PUNCT
admet-1513	103	1	however	however	ADV
admet-1513	103	2	,	,	PUNCT
admet-1513	103	3	this	this	DET
admet-1513	103	4	model	model	NOUN
admet-1513	103	5	is	be	AUX
admet-1513	103	6	most	most	ADV
admet-1513	103	7	useful	useful	ADJ
admet-1513	103	8	for	for	ADP
admet-1513	103	9	studying	study	VERB
admet-1513	103	10	the	the	DET
admet-1513	103	11	absorptivity	absorptivity	NOUN
admet-1513	103	12	of	of	ADP
admet-1513	103	13	foods	food	NOUN
admet-1513	103	14	and	and	CCONJ
admet-1513	103	15	xenobiotics	xenobiotic	NOUN
admet-1513	103	16	due	due	ADP
admet-1513	103	17	to	to	ADP
admet-1513	103	18	its	its	PRON
admet-1513	103	19	characteristic	characteristic	ADJ
admet-1513	103	20	feature	feature	NOUN
admet-1513	103	21	of	of	ADP
admet-1513	103	22	producing	produce	VERB
admet-1513	103	23	mucus	mucus	NOUN
admet-1513	103	24	-	-	PUNCT
admet-1513	103	25	like	like	ADJ
admet-1513	103	26	substances	substance	NOUN
admet-1513	103	27	since	since	SCONJ
admet-1513	103	28	it	it	PRON
admet-1513	103	29	influences	influence	VERB
admet-1513	103	30	intestinal	intestinal	ADJ
admet-1513	103	31	tissue	tissue	NOUN
admet-1513	103	32	homeostasis	homeostasis	NOUN
admet-1513	103	33	[	[	X
admet-1513	103	34	44	44	NUM
admet-1513	103	35	]	]	PUNCT
admet-1513	103	36	.	.	PUNCT
admet-1513	104	1	admet	admet	PROPN
admet-1513	104	2	&	&	CCONJ
admet-1513	104	3	dmpk	dmpk	PROPN
admet-1513	104	4	11(1	11(1	NUM
admet-1513	104	5	)	)	PUNCT
admet-1513	104	6	(	(	PUNCT
admet-1513	104	7	2023	2023	NUM
admet-1513	104	8	)	)	PUNCT
admet-1513	104	9	1	1	NUM
admet-1513	104	10	-	-	SYM
admet-1513	104	11	32	32	NUM
admet-1513	104	12	2d	2d	NOUN
admet-1513	104	13	and	and	CCONJ
admet-1513	104	14	3d	3d	NOUN
admet-1513	104	15	adme	adme	PROPN
admet-1513	104	16	-	-	PUNCT
admet-1513	104	17	tox	tox	NOUN
admet-1513	104	18	cell	cell	NOUN
admet-1513	104	19	culture	culture	NOUN
admet-1513	104	20	screening	screen	VERB
admet-1513	104	21	:	:	PUNCT
admet-1513	104	22	a	a	DET
admet-1513	104	23	review	review	NOUN
admet-1513	104	24	doi	doi	NOUN
admet-1513	104	25	:	:	PUNCT
admet-1513	104	26	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	104	27	5	5	NUM
admet-1513	104	28	iec	iec	NOUN
admet-1513	104	29	(	(	PUNCT
admet-1513	104	30	intestinal	intestinal	ADJ
admet-1513	104	31	epithelial	epithelial	ADJ
admet-1513	104	32	cell	cell	NOUN
admet-1513	104	33	line	line	NOUN
admet-1513	104	34	)	)	PUNCT
admet-1513	104	35	rat	rat	NOUN
admet-1513	104	36	iec	iec	NOUN
admet-1513	104	37	derived	derive	VERB
admet-1513	104	38	from	from	ADP
admet-1513	104	39	rat	rat	NOUN
admet-1513	104	40	ileal	ileal	ADJ
admet-1513	104	41	crypts	crypt	NOUN
admet-1513	104	42	is	be	AUX
admet-1513	104	43	another	another	DET
admet-1513	104	44	model	model	NOUN
admet-1513	104	45	which	which	PRON
admet-1513	104	46	gained	gain	VERB
admet-1513	104	47	importance	importance	NOUN
admet-1513	104	48	in	in	ADP
admet-1513	104	49	drug	drug	NOUN
admet-1513	104	50	permeability	permeability	NOUN
admet-1513	104	51	studies	study	NOUN
admet-1513	104	52	[	[	X
admet-1513	104	53	45	45	NUM
admet-1513	104	54	]	]	PUNCT
admet-1513	104	55	.	.	PUNCT
admet-1513	105	1	among	among	ADP
admet-1513	105	2	different	different	ADJ
admet-1513	105	3	iec	iec	NOUN
admet-1513	105	4	subclones	subclone	NOUN
admet-1513	105	5	,	,	PUNCT
admet-1513	105	6	iec-18	iec-18	NOUN
admet-1513	105	7	is	be	AUX
admet-1513	105	8	the	the	DET
admet-1513	105	9	most	most	ADV
admet-1513	105	10	commonly	commonly	ADV
admet-1513	105	11	used	use	VERB
admet-1513	105	12	cell	cell	NOUN
admet-1513	105	13	line	line	NOUN
admet-1513	105	14	.	.	PUNCT
admet-1513	106	1	they	they	PRON
admet-1513	106	2	develop	develop	VERB
admet-1513	106	3	confluent	confluent	ADJ
admet-1513	106	4	epithelium	epithelium	NOUN
admet-1513	106	5	when	when	SCONJ
admet-1513	106	6	grown	grow	VERB
admet-1513	106	7	on	on	ADP
admet-1513	106	8	rat	rat	NOUN
admet-1513	106	9	mesenchymal	mesenchymal	NOUN
admet-1513	106	10	or	or	CCONJ
admet-1513	106	11	similar	similar	ADJ
admet-1513	106	12	tissue	tissue	NOUN
admet-1513	106	13	[	[	X
admet-1513	106	14	46	46	NUM
admet-1513	106	15	]	]	PUNCT
admet-1513	106	16	.	.	PUNCT
admet-1513	107	1	the	the	DET
admet-1513	107	2	characteristic	characteristic	ADJ
admet-1513	107	3	features	feature	NOUN
admet-1513	107	4	include	include	VERB
admet-1513	107	5	the	the	DET
admet-1513	107	6	presence	presence	NOUN
admet-1513	107	7	of	of	ADP
admet-1513	107	8	tight	tight	ADJ
admet-1513	107	9	junctions	junction	NOUN
admet-1513	107	10	and	and	CCONJ
admet-1513	107	11	desmosomes	desmosome	NOUN
admet-1513	107	12	between	between	ADP
admet-1513	107	13	the	the	DET
admet-1513	107	14	cells	cell	NOUN
admet-1513	107	15	and	and	CCONJ
admet-1513	107	16	microvilli	microvilli	NOUN
admet-1513	107	17	on	on	ADP
admet-1513	107	18	their	their	PRON
admet-1513	107	19	apical	apical	ADJ
admet-1513	107	20	surface	surface	NOUN
admet-1513	107	21	.	.	PUNCT
admet-1513	108	1	the	the	DET
admet-1513	108	2	lower	low	ADJ
admet-1513	108	3	teer	teer	NOUN
admet-1513	108	4	(	(	PUNCT
admet-1513	108	5	28	28	NUM
admet-1513	108	6	-	-	SYM
admet-1513	108	7	55	55	NUM
admet-1513	108	8	ω⋅cm2	ω⋅cm2	NOUN
admet-1513	108	9	)	)	PUNCT
admet-1513	108	10	in	in	ADP
admet-1513	108	11	the	the	DET
admet-1513	108	12	iec-18	iec-18	NOUN
admet-1513	108	13	indicates	indicate	VERB
admet-1513	108	14	higher	high	ADJ
admet-1513	108	15	paracellular	paracellular	ADJ
admet-1513	108	16	permeation	permeation	NOUN
admet-1513	108	17	than	than	ADP
admet-1513	108	18	the	the	DET
admet-1513	108	19	caco2	caco2	NOUN
admet-1513	108	20	model	model	NOUN
admet-1513	108	21	.	.	PUNCT
admet-1513	109	1	ma	ma	PROPN
admet-1513	109	2	and	and	CCONJ
admet-1513	109	3	colleagues	colleague	NOUN
admet-1513	110	1	[	[	X
admet-1513	110	2	46	46	NUM
admet-1513	110	3	]	]	PUNCT
admet-1513	110	4	checked	check	VERB
admet-1513	110	5	the	the	DET
admet-1513	110	6	paracellular	paracellular	ADJ
admet-1513	110	7	hydrophilic	hydrophilic	ADJ
admet-1513	110	8	markers	marker	NOUN
admet-1513	110	9	like	like	ADP
admet-1513	110	10	mannitol	mannitol	NOUN
admet-1513	110	11	,	,	PUNCT
admet-1513	110	12	dextran	dextran	NOUN
admet-1513	110	13	and	and	CCONJ
admet-1513	110	14	peg-4000	peg-4000	NOUN
admet-1513	110	15	and	and	CCONJ
admet-1513	110	16	observed	observe	VERB
admet-1513	110	17	greater	great	ADJ
admet-1513	110	18	permeability	permeability	NOUN
admet-1513	110	19	across	across	ADP
admet-1513	110	20	iec-18	iec-18	NOUN
admet-1513	110	21	than	than	ADP
admet-1513	110	22	colonic	colonic	ADJ
admet-1513	110	23	cells	cell	NOUN
admet-1513	110	24	.	.	PUNCT
admet-1513	111	1	human	human	ADJ
admet-1513	111	2	intestinal	intestinal	ADJ
admet-1513	111	3	epithelial	epithelial	ADJ
admet-1513	111	4	cells	cell	NOUN
admet-1513	111	5	(	(	PUNCT
admet-1513	111	6	hiec	hiec	NOUN
admet-1513	111	7	)	)	PUNCT
admet-1513	111	8	are	be	AUX
admet-1513	111	9	another	another	DET
admet-1513	111	10	cell	cell	NOUN
admet-1513	111	11	line	line	NOUN
admet-1513	111	12	gaining	gain	VERB
admet-1513	111	13	attention	attention	NOUN
admet-1513	111	14	over	over	ADP
admet-1513	111	15	caco-2	caco-2	NUM
admet-1513	111	16	and	and	CCONJ
admet-1513	111	17	ht29	ht29	PROPN
admet-1513	111	18	due	due	ADP
admet-1513	111	19	to	to	ADP
admet-1513	111	20	similar	similar	ADJ
admet-1513	111	21	morphology	morphology	NOUN
admet-1513	111	22	to	to	ADP
admet-1513	111	23	the	the	DET
admet-1513	111	24	in	in	ADP
admet-1513	111	25	vivo	vivo	ADJ
admet-1513	111	26	intestine	intestine	NOUN
admet-1513	111	27	.	.	PUNCT
admet-1513	112	1	the	the	DET
admet-1513	112	2	characteristic	characteristic	ADJ
admet-1513	112	3	features	feature	NOUN
admet-1513	112	4	include	include	VERB
admet-1513	112	5	polarized	polarize	VERB
admet-1513	112	6	columnar	columnar	ADJ
admet-1513	112	7	cells	cell	NOUN
admet-1513	112	8	,	,	PUNCT
admet-1513	112	9	mono	mono	NOUN
admet-1513	112	10	-	-	PUNCT
admet-1513	112	11	layer	layer	NOUN
admet-1513	112	12	formation	formation	NOUN
admet-1513	112	13	,	,	PUNCT
admet-1513	112	14	and	and	CCONJ
admet-1513	112	15	dense	dense	ADJ
admet-1513	112	16	microvilli	microvilli	NOUN
admet-1513	112	17	.	.	PUNCT
admet-1513	113	1	in	in	ADP
admet-1513	113	2	addition	addition	NOUN
admet-1513	113	3	,	,	PUNCT
admet-1513	113	4	the	the	DET
admet-1513	113	5	teer	teer	NOUN
admet-1513	113	6	value	value	NOUN
admet-1513	113	7	is	be	AUX
admet-1513	113	8	98.9	98.9	NUM
admet-1513	113	9	ω⋅cm2	ω⋅cm2	ADJ
admet-1513	113	10	which	which	PRON
admet-1513	113	11	is	be	AUX
admet-1513	113	12	in	in	ADP
admet-1513	113	13	a	a	DET
admet-1513	113	14	similar	similar	ADJ
admet-1513	113	15	range	range	NOUN
admet-1513	113	16	to	to	ADP
admet-1513	113	17	in	in	ADP
admet-1513	113	18	vivo	vivo	ADJ
admet-1513	113	19	conditions	condition	NOUN
admet-1513	113	20	due	due	ADP
admet-1513	113	21	to	to	ADP
admet-1513	113	22	its	its	PRON
admet-1513	113	23	poor	poor	ADJ
admet-1513	113	24	organization	organization	NOUN
admet-1513	113	25	of	of	ADP
admet-1513	113	26	tight	tight	ADJ
admet-1513	113	27	junctions	junction	NOUN
admet-1513	113	28	[	[	X
admet-1513	113	29	47,48	47,48	NOUN
admet-1513	113	30	]	]	X
admet-1513	113	31	.	.	PUNCT
admet-1513	114	1	takenaka	takenaka	PROPN
admet-1513	114	2	and	and	CCONJ
admet-1513	114	3	colleagues	colleague	NOUN
admet-1513	115	1	[	[	X
admet-1513	115	2	49	49	NUM
admet-1513	115	3	]	]	PUNCT
admet-1513	115	4	evaluated	evaluate	VERB
admet-1513	115	5	the	the	DET
admet-1513	115	6	papp	papp	NOUN
admet-1513	115	7	and	and	CCONJ
admet-1513	115	8	intestinal	intestinal	ADJ
admet-1513	115	9	fraction	fraction	NOUN
admet-1513	115	10	absorbed	absorb	VERB
admet-1513	115	11	(	(	PUNCT
admet-1513	115	12	fa	fa	NOUN
admet-1513	115	13	)	)	PUNCT
admet-1513	115	14	of	of	ADP
admet-1513	115	15	polyethylene	polyethylene	NOUN
admet-1513	115	16	glycol	glycol	NOUN
admet-1513	115	17	oligomer	oligomer	ADJ
admet-1513	115	18	compounds	compound	NOUN
admet-1513	115	19	in	in	ADP
admet-1513	115	20	the	the	DET
admet-1513	115	21	hiec	hiec	NOUN
admet-1513	115	22	model	model	NOUN
admet-1513	115	23	and	and	CCONJ
admet-1513	115	24	caco-2	caco-2	NOUN
admet-1513	115	25	.	.	PUNCT
admet-1513	116	1	the	the	DET
admet-1513	116	2	results	result	NOUN
admet-1513	116	3	suggested	suggest	VERB
admet-1513	116	4	that	that	SCONJ
admet-1513	116	5	the	the	DET
admet-1513	116	6	hiec	hiec	NOUN
admet-1513	116	7	monolayer	monolayer	NOUN
admet-1513	116	8	had	have	VERB
admet-1513	116	9	markedly	markedly	ADV
admet-1513	116	10	higher	high	ADJ
admet-1513	116	11	precision	precision	NOUN
admet-1513	116	12	to	to	PART
admet-1513	116	13	predict	predict	VERB
admet-1513	116	14	fa	fa	PROPN
admet-1513	116	15	values	value	NOUN
admet-1513	116	16	compared	compare	VERB
admet-1513	116	17	to	to	ADP
admet-1513	116	18	the	the	DET
admet-1513	116	19	caco-2	caco-2	NUM
admet-1513	116	20	cells	cell	NOUN
admet-1513	116	21	.	.	PUNCT
admet-1513	117	1	moreover	moreover	ADV
admet-1513	117	2	,	,	PUNCT
admet-1513	117	3	hiec	hiec	NOUN
admet-1513	117	4	accurately	accurately	ADV
admet-1513	117	5	classified	classify	VERB
admet-1513	117	6	23	23	NUM
admet-1513	117	7	drug	drug	NOUN
admet-1513	117	8	compounds	compound	NOUN
admet-1513	117	9	having	have	VERB
admet-1513	117	10	different	different	ADJ
admet-1513	117	11	fa	fa	NOUN
admet-1513	117	12	than	than	ADP
admet-1513	117	13	caco-2	caco-2	NUM
admet-1513	117	14	[	[	X
admet-1513	117	15	49	49	NUM
admet-1513	117	16	]	]	PUNCT
admet-1513	117	17	.	.	PUNCT
admet-1513	118	1	distribution	distribution	NOUN
admet-1513	118	2	after	after	ADP
admet-1513	118	3	the	the	DET
admet-1513	118	4	drug	drug	NOUN
admet-1513	118	5	absorption	absorption	NOUN
admet-1513	118	6	,	,	PUNCT
admet-1513	118	7	it	it	PRON
admet-1513	118	8	enters	enter	VERB
admet-1513	118	9	systemic	systemic	ADJ
admet-1513	118	10	circulation	circulation	NOUN
admet-1513	118	11	,	,	PUNCT
admet-1513	118	12	from	from	ADP
admet-1513	118	13	where	where	SCONJ
admet-1513	118	14	the	the	DET
admet-1513	118	15	distribution	distribution	NOUN
admet-1513	118	16	process	process	NOUN
admet-1513	118	17	of	of	ADP
admet-1513	118	18	the	the	DET
admet-1513	118	19	drug	drug	NOUN
admet-1513	118	20	occurs	occur	VERB
admet-1513	118	21	.	.	PUNCT
admet-1513	119	1	distribution	distribution	NOUN
admet-1513	119	2	refers	refer	VERB
admet-1513	119	3	to	to	ADP
admet-1513	119	4	the	the	DET
admet-1513	119	5	transfer	transfer	NOUN
admet-1513	119	6	of	of	ADP
admet-1513	119	7	a	a	DET
admet-1513	119	8	drug	drug	NOUN
admet-1513	119	9	from	from	ADP
admet-1513	119	10	the	the	DET
admet-1513	119	11	intravascular	intravascular	NOUN
admet-1513	119	12	(	(	PUNCT
admet-1513	119	13	blood	blood	NOUN
admet-1513	119	14	/	/	SYM
admet-1513	119	15	plasma	plasma	NOUN
admet-1513	119	16	)	)	PUNCT
admet-1513	119	17	and	and	CCONJ
admet-1513	119	18	extravascular	extravascular	ADJ
admet-1513	119	19	(	(	PUNCT
admet-1513	119	20	intracellular	intracellular	ADJ
admet-1513	119	21	&	&	CCONJ
admet-1513	119	22	extracellular	extracellular	ADJ
admet-1513	119	23	)	)	PUNCT
admet-1513	119	24	compartments	compartment	NOUN
admet-1513	119	25	and	and	CCONJ
admet-1513	119	26	vice	vice	NOUN
admet-1513	119	27	versa	versa	NOUN
admet-1513	119	28	of	of	ADP
admet-1513	119	29	the	the	DET
admet-1513	119	30	body	body	NOUN
admet-1513	119	31	[	[	X
admet-1513	119	32	50	50	NUM
admet-1513	119	33	]	]	PUNCT
admet-1513	119	34	.	.	PUNCT
admet-1513	120	1	the	the	DET
admet-1513	120	2	drug	drug	NOUN
admet-1513	120	3	distribution	distribution	NOUN
admet-1513	120	4	process	process	NOUN
admet-1513	120	5	is	be	AUX
admet-1513	120	6	important	important	ADJ
admet-1513	120	7	because	because	SCONJ
admet-1513	120	8	it	it	PRON
admet-1513	120	9	can	can	AUX
admet-1513	120	10	affect	affect	VERB
admet-1513	120	11	the	the	DET
admet-1513	120	12	amount	amount	NOUN
admet-1513	120	13	of	of	ADP
admet-1513	120	14	drug	drug	NOUN
admet-1513	120	15	that	that	PRON
admet-1513	120	16	ends	end	VERB
admet-1513	120	17	up	up	ADP
admet-1513	120	18	in	in	ADP
admet-1513	120	19	the	the	DET
admet-1513	120	20	active	active	ADJ
admet-1513	120	21	sites	site	NOUN
admet-1513	120	22	and	and	CCONJ
admet-1513	120	23	,	,	PUNCT
admet-1513	120	24	thus	thus	ADV
admet-1513	120	25	,	,	PUNCT
admet-1513	120	26	drug	drug	NOUN
admet-1513	120	27	efficacy	efficacy	NOUN
admet-1513	120	28	and	and	CCONJ
admet-1513	120	29	toxicity	toxicity	NOUN
admet-1513	120	30	.	.	PUNCT
admet-1513	121	1	a	a	DET
admet-1513	121	2	drug	drug	NOUN
admet-1513	121	3	will	will	AUX
admet-1513	121	4	move	move	VERB
admet-1513	121	5	from	from	ADP
admet-1513	121	6	the	the	DET
admet-1513	121	7	absorption	absorption	NOUN
admet-1513	121	8	site	site	NOUN
admet-1513	121	9	to	to	ADP
admet-1513	121	10	tissues	tissue	NOUN
admet-1513	121	11	around	around	ADP
admet-1513	121	12	the	the	DET
admet-1513	121	13	body	body	NOUN
admet-1513	121	14	,	,	PUNCT
admet-1513	121	15	such	such	ADJ
admet-1513	121	16	as	as	ADP
admet-1513	121	17	brain	brain	NOUN
admet-1513	121	18	tissue	tissue	NOUN
admet-1513	121	19	,	,	PUNCT
admet-1513	121	20	fat	fat	ADJ
admet-1513	121	21	,	,	PUNCT
admet-1513	121	22	and	and	CCONJ
admet-1513	121	23	muscle	muscle	NOUN
admet-1513	121	24	.	.	PUNCT
admet-1513	122	1	the	the	DET
admet-1513	122	2	distribution	distribution	NOUN
admet-1513	122	3	process	process	NOUN
admet-1513	122	4	mainly	mainly	ADV
admet-1513	122	5	occurs	occur	VERB
admet-1513	122	6	through	through	ADP
admet-1513	122	7	systemic	systemic	ADJ
admet-1513	122	8	circulation	circulation	NOUN
admet-1513	122	9	,	,	PUNCT
admet-1513	122	10	i.e.	i.e.	X
admet-1513	122	11	,	,	PUNCT
admet-1513	122	12	blood	blood	NOUN
admet-1513	122	13	,	,	PUNCT
admet-1513	122	14	and	and	CCONJ
admet-1513	122	15	is	be	AUX
admet-1513	122	16	influenced	influence	VERB
admet-1513	122	17	by	by	ADP
admet-1513	122	18	blood	blood	NOUN
admet-1513	122	19	flow	flow	NOUN
admet-1513	122	20	,	,	PUNCT
admet-1513	122	21	lipophilicity	lipophilicity	NOUN
admet-1513	122	22	,	,	PUNCT
admet-1513	122	23	molecular	molecular	ADJ
admet-1513	122	24	size	size	NOUN
admet-1513	122	25	,	,	PUNCT
admet-1513	122	26	drug	drug	NOUN
admet-1513	122	27	interaction	interaction	NOUN
admet-1513	122	28	with	with	ADP
admet-1513	122	29	the	the	DET
admet-1513	122	30	blood	blood	NOUN
admet-1513	122	31	components	component	NOUN
admet-1513	122	32	,	,	PUNCT
admet-1513	122	33	like	like	ADP
admet-1513	122	34	plasma	plasma	NOUN
admet-1513	122	35	proteins	protein	NOUN
admet-1513	122	36	and	and	CCONJ
admet-1513	122	37	partition	partition	NOUN
admet-1513	122	38	/	/	SYM
admet-1513	122	39	distribution	distribution	NOUN
admet-1513	122	40	coefficients	coefficient	NOUN
admet-1513	122	41	.	.	PUNCT
admet-1513	123	1	researchers	researcher	NOUN
admet-1513	123	2	have	have	AUX
admet-1513	123	3	developed	develop	VERB
admet-1513	123	4	several	several	ADJ
admet-1513	123	5	in	in	ADP
admet-1513	123	6	vitro	vitro	X
admet-1513	123	7	assays	assay	NOUN
admet-1513	123	8	to	to	PART
admet-1513	123	9	assess	assess	VERB
admet-1513	123	10	the	the	DET
admet-1513	123	11	distribution	distribution	NOUN
admet-1513	123	12	process	process	NOUN
admet-1513	123	13	,	,	PUNCT
admet-1513	123	14	like	like	ADP
admet-1513	123	15	lipophilicity	lipophilicity	NOUN
admet-1513	123	16	,	,	PUNCT
admet-1513	123	17	solubility	solubility	NOUN
admet-1513	123	18	,	,	PUNCT
admet-1513	123	19	plasma	plasma	NOUN
admet-1513	123	20	stability	stability	NOUN
admet-1513	123	21	and	and	CCONJ
admet-1513	123	22	plasma	plasma	NOUN
admet-1513	123	23	protein	protein	NOUN
admet-1513	123	24	binding	bind	VERB
admet-1513	123	25	[	[	X
admet-1513	123	26	11	11	NUM
admet-1513	123	27	]	]	PUNCT
admet-1513	123	28	.	.	PUNCT
admet-1513	124	1	lipophilicity	lipophilicity	PROPN
admet-1513	124	2	gives	give	VERB
admet-1513	124	3	the	the	DET
admet-1513	124	4	partition	partition	NOUN
admet-1513	124	5	coefficient	coefficient	NOUN
admet-1513	124	6	(	(	PUNCT
admet-1513	124	7	log	log	VERB
admet-1513	124	8	p	p	NOUN
admet-1513	124	9	)	)	PUNCT
admet-1513	124	10	of	of	ADP
admet-1513	124	11	the	the	DET
admet-1513	124	12	drugs	drug	NOUN
admet-1513	124	13	between	between	ADP
admet-1513	124	14	aqueous	aqueous	ADJ
admet-1513	124	15	and	and	CCONJ
admet-1513	124	16	non	non	ADJ
admet-1513	124	17	-	-	ADJ
admet-1513	124	18	aqueous	aqueous	ADJ
admet-1513	124	19	phases	phase	NOUN
admet-1513	124	20	under	under	ADP
admet-1513	124	21	non	non	ADJ
admet-1513	124	22	-	-	ADJ
admet-1513	124	23	ionic	ionic	ADJ
admet-1513	124	24	conditions	condition	NOUN
admet-1513	124	25	.	.	PUNCT
admet-1513	125	1	it	it	PRON
admet-1513	125	2	is	be	AUX
admet-1513	125	3	also	also	ADV
admet-1513	125	4	used	use	VERB
admet-1513	125	5	for	for	ADP
admet-1513	125	6	the	the	DET
admet-1513	125	7	determination	determination	NOUN
admet-1513	125	8	of	of	ADP
admet-1513	125	9	the	the	DET
admet-1513	125	10	distribution	distribution	NOUN
admet-1513	125	11	coefficient	coefficient	NOUN
admet-1513	125	12	(	(	PUNCT
admet-1513	125	13	log	log	NOUN
admet-1513	125	14	d	d	NOUN
admet-1513	125	15	)	)	PUNCT
admet-1513	125	16	of	of	ADP
admet-1513	125	17	the	the	DET
admet-1513	125	18	drug	drug	NOUN
admet-1513	125	19	molecules	molecule	NOUN
admet-1513	125	20	in	in	ADP
admet-1513	125	21	ionized	ionized	ADJ
admet-1513	125	22	forms	form	NOUN
admet-1513	125	23	.	.	PUNCT
admet-1513	126	1	since	since	SCONJ
admet-1513	126	2	most	most	ADJ
admet-1513	126	3	of	of	ADP
admet-1513	126	4	the	the	DET
admet-1513	126	5	drug	drug	NOUN
admet-1513	126	6	molecules	molecule	NOUN
admet-1513	126	7	contain	contain	VERB
admet-1513	126	8	ionizable	ionizable	ADJ
admet-1513	126	9	groups	group	NOUN
admet-1513	126	10	,	,	PUNCT
admet-1513	126	11	they	they	PRON
admet-1513	126	12	are	be	AUX
admet-1513	126	13	likely	likely	ADJ
admet-1513	126	14	to	to	PART
admet-1513	126	15	be	be	AUX
admet-1513	126	16	charged	charge	VERB
admet-1513	126	17	at	at	ADP
admet-1513	126	18	physiological	physiological	ADJ
admet-1513	126	19	ph	ph	NOUN
admet-1513	126	20	(	(	PUNCT
admet-1513	126	21	log	log	NOUN
admet-1513	126	22	d	d	NOUN
admet-1513	126	23	7.4	7.4	NUM
admet-1513	126	24	)	)	PUNCT
admet-1513	127	1	[	[	X
admet-1513	127	2	11	11	NUM
admet-1513	127	3	]	]	PUNCT
admet-1513	127	4	.	.	PUNCT
admet-1513	128	1	aqueous	aqueous	ADJ
admet-1513	128	2	solubility	solubility	NOUN
admet-1513	128	3	measurement	measurement	NOUN
admet-1513	128	4	at	at	ADP
admet-1513	128	5	physiological	physiological	ADJ
admet-1513	128	6	ph	ph	NOUN
admet-1513	128	7	is	be	AUX
admet-1513	128	8	another	another	DET
admet-1513	128	9	important	important	ADJ
admet-1513	128	10	parameter	parameter	NOUN
admet-1513	128	11	for	for	ADP
admet-1513	128	12	estimating	estimate	VERB
admet-1513	128	13	the	the	DET
admet-1513	128	14	distribution	distribution	NOUN
admet-1513	128	15	process	process	NOUN
admet-1513	128	16	.	.	PUNCT
admet-1513	129	1	poor	poor	ADJ
admet-1513	129	2	soluble	soluble	ADJ
admet-1513	129	3	compounds	compound	NOUN
admet-1513	129	4	will	will	AUX
admet-1513	129	5	affect	affect	VERB
admet-1513	129	6	the	the	DET
admet-1513	129	7	adme	adme	NOUN
admet-1513	129	8	analysis	analysis	NOUN
admet-1513	129	9	,	,	PUNCT
admet-1513	129	10	as	as	SCONJ
admet-1513	129	11	a	a	DET
admet-1513	129	12	fraction	fraction	NOUN
admet-1513	129	13	of	of	ADP
admet-1513	129	14	the	the	DET
admet-1513	129	15	compound	compound	NOUN
admet-1513	129	16	gets	get	AUX
admet-1513	129	17	precipitated	precipitate	VERB
admet-1513	129	18	,	,	PUNCT
admet-1513	129	19	which	which	PRON
admet-1513	129	20	may	may	AUX
admet-1513	129	21	lead	lead	VERB
admet-1513	129	22	to	to	ADP
admet-1513	129	23	the	the	DET
admet-1513	129	24	unavailability	unavailability	NOUN
admet-1513	129	25	of	of	ADP
admet-1513	129	26	the	the	DET
admet-1513	129	27	action	action	NOUN
admet-1513	129	28	cites	cite	VERB
admet-1513	129	29	.	.	PUNCT
admet-1513	130	1	the	the	DET
admet-1513	130	2	stability	stability	NOUN
admet-1513	130	3	of	of	ADP
admet-1513	130	4	drug	drug	NOUN
admet-1513	130	5	compounds	compound	NOUN
admet-1513	130	6	in	in	ADP
admet-1513	130	7	plasma	plasma	NOUN
admet-1513	130	8	is	be	AUX
admet-1513	130	9	another	another	DET
admet-1513	130	10	essential	essential	ADJ
admet-1513	130	11	factor	factor	NOUN
admet-1513	130	12	to	to	PART
admet-1513	130	13	assess	assess	VERB
admet-1513	130	14	the	the	DET
admet-1513	130	15	possible	possible	ADJ
admet-1513	130	16	degradation	degradation	NOUN
admet-1513	130	17	or	or	CCONJ
admet-1513	130	18	protein	protein	NOUN
admet-1513	130	19	binding	bind	VERB
admet-1513	130	20	issues	issue	NOUN
admet-1513	130	21	,	,	PUNCT
admet-1513	130	22	as	as	SCONJ
admet-1513	130	23	the	the	DET
admet-1513	130	24	blood	blood	NOUN
admet-1513	130	25	plasma	plasma	NOUN
admet-1513	130	26	contains	contain	VERB
admet-1513	130	27	enzymes	enzyme	NOUN
admet-1513	130	28	like	like	ADP
admet-1513	130	29	hydrolases	hydrolase	NOUN
admet-1513	130	30	and	and	CCONJ
admet-1513	130	31	esterases	esterase	NOUN
admet-1513	130	32	.	.	PUNCT
admet-1513	131	1	these	these	PRON
admet-1513	131	2	can	can	AUX
admet-1513	131	3	affect	affect	VERB
admet-1513	131	4	both	both	CCONJ
admet-1513	131	5	the	the	DET
admet-1513	131	6	approach	approach	NOUN
admet-1513	131	7	and	and	CCONJ
admet-1513	131	8	design	design	NOUN
admet-1513	131	9	of	of	ADP
admet-1513	131	10	the	the	DET
admet-1513	131	11	bioanalytical	bioanalytical	ADJ
admet-1513	131	12	assay	assay	NOUN
admet-1513	131	13	as	as	ADV
admet-1513	131	14	well	well	ADV
admet-1513	131	15	as	as	ADP
admet-1513	131	16	the	the	PRON
admet-1513	131	17	in	in	ADP
admet-1513	131	18	vivo	vivo	ADJ
admet-1513	131	19	outcomes	outcome	NOUN
admet-1513	131	20	.	.	PUNCT
admet-1513	132	1	plasma	plasma	NOUN
admet-1513	132	2	protein	protein	NOUN
admet-1513	132	3	binding	bind	VERB
admet-1513	132	4	is	be	AUX
admet-1513	132	5	assessed	assess	VERB
admet-1513	132	6	to	to	PART
admet-1513	132	7	determine	determine	VERB
admet-1513	132	8	the	the	DET
admet-1513	132	9	amount	amount	NOUN
admet-1513	132	10	of	of	ADP
admet-1513	132	11	freely	freely	ADV
admet-1513	132	12	available	available	ADJ
admet-1513	132	13	drugs	drug	NOUN
admet-1513	132	14	in	in	ADP
admet-1513	132	15	the	the	DET
admet-1513	132	16	plasma	plasma	NOUN
admet-1513	132	17	for	for	ADP
admet-1513	132	18	distribution	distribution	NOUN
admet-1513	132	19	to	to	ADP
admet-1513	132	20	the	the	DET
admet-1513	132	21	active	active	ADJ
admet-1513	132	22	sites	site	NOUN
admet-1513	132	23	.	.	PUNCT
admet-1513	133	1	when	when	SCONJ
admet-1513	133	2	the	the	DET
admet-1513	133	3	drug	drug	NOUN
admet-1513	133	4	gets	get	AUX
admet-1513	133	5	absorbed	absorb	VERB
admet-1513	133	6	into	into	ADP
admet-1513	133	7	the	the	DET
admet-1513	133	8	blood	blood	NOUN
admet-1513	133	9	,	,	PUNCT
admet-1513	133	10	the	the	DET
admet-1513	133	11	majority	majority	NOUN
admet-1513	133	12	of	of	ADP
admet-1513	133	13	the	the	DET
admet-1513	133	14	drug	drug	NOUN
admet-1513	133	15	fraction	fraction	NOUN
admet-1513	133	16	binds	bind	VERB
admet-1513	133	17	to	to	ADP
admet-1513	133	18	the	the	DET
admet-1513	133	19	plasma	plasma	NOUN
admet-1513	133	20	proteins	protein	NOUN
admet-1513	133	21	,	,	PUNCT
admet-1513	133	22	and	and	CCONJ
admet-1513	133	23	subsequently	subsequently	ADV
admet-1513	133	24	,	,	PUNCT
admet-1513	133	25	the	the	DET
admet-1513	133	26	amount	amount	NOUN
admet-1513	133	27	of	of	ADP
admet-1513	133	28	drug	drug	NOUN
admet-1513	133	29	available	available	ADJ
admet-1513	133	30	to	to	PART
admet-1513	133	31	reach	reach	VERB
admet-1513	133	32	the	the	DET
admet-1513	133	33	target	target	NOUN
admet-1513	133	34	is	be	AUX
admet-1513	133	35	reduced	reduce	VERB
admet-1513	133	36	,	,	PUNCT
admet-1513	133	37	thus	thus	ADV
admet-1513	133	38	determining	determine	VERB
admet-1513	133	39	the	the	DET
admet-1513	133	40	drug	drug	NOUN
admet-1513	133	41	efficacy	efficacy	NOUN
admet-1513	133	42	,	,	PUNCT
admet-1513	133	43	metabolism	metabolism	NOUN
admet-1513	133	44	and	and	CCONJ
admet-1513	133	45	other	other	ADJ
admet-1513	133	46	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	133	47	parameters	parameter	NOUN
admet-1513	133	48	.	.	PUNCT
admet-1513	134	1	in	in	ADP
admet-1513	134	2	contrast	contrast	NOUN
admet-1513	134	3	,	,	PUNCT
admet-1513	134	4	drugs	drug	NOUN
admet-1513	134	5	that	that	PRON
admet-1513	134	6	are	be	AUX
admet-1513	134	7	less	less	ADV
admet-1513	134	8	bound	bind	VERB
admet-1513	134	9	to	to	ADP
admet-1513	134	10	plasma	plasma	NOUN
admet-1513	134	11	proteins	protein	NOUN
admet-1513	134	12	are	be	AUX
admet-1513	134	13	highly	highly	ADV
admet-1513	134	14	available	available	ADJ
admet-1513	134	15	for	for	ADP
admet-1513	134	16	distribution	distribution	NOUN
admet-1513	134	17	to	to	ADP
admet-1513	134	18	the	the	DET
admet-1513	134	19	organs	organ	NOUN
admet-1513	134	20	and	and	CCONJ
admet-1513	134	21	tissues	tissue	NOUN
admet-1513	134	22	,	,	PUNCT
admet-1513	134	23	whereas	whereas	SCONJ
admet-1513	134	24	drugs	drug	NOUN
admet-1513	134	25	with	with	ADP
admet-1513	134	26	high	high	ADJ
admet-1513	134	27	binding	binding	NOUN
admet-1513	134	28	are	be	AUX
admet-1513	134	29	only	only	ADV
admet-1513	134	30	restricted	restrict	VERB
admet-1513	134	31	to	to	ADP
admet-1513	134	32	vascular	vascular	ADJ
admet-1513	134	33	spaces	space	NOUN
admet-1513	134	34	and	and	CCONJ
admet-1513	134	35	have	have	VERB
admet-1513	134	36	a	a	DET
admet-1513	134	37	very	very	ADV
admet-1513	134	38	low	low	ADJ
admet-1513	134	39	volume	volume	NOUN
admet-1513	134	40	of	of	ADP
admet-1513	134	41	distribution	distribution	NOUN
admet-1513	134	42	.	.	PUNCT
admet-1513	135	1	metabolism	metabolism	NOUN
admet-1513	135	2	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	135	3	venkatesh	venkatesh	PROPN
admet-1513	135	4	chunduri	chunduri	PROPN
admet-1513	135	5	and	and	CCONJ
admet-1513	135	6	srinivas	srinivas	PROPN
admet-1513	135	7	maddi	maddi	PROPN
admet-1513	135	8	admet	admet	PROPN
admet-1513	135	9	&	&	CCONJ
admet-1513	135	10	dmpk	dmpk	PROPN
admet-1513	135	11	11(1	11(1	NUM
admet-1513	135	12	)	)	PUNCT
admet-1513	135	13	(	(	PUNCT
admet-1513	135	14	2023	2023	NUM
admet-1513	135	15	)	)	PUNCT
admet-1513	135	16	1	1	NUM
admet-1513	135	17	-	-	SYM
admet-1513	135	18	32	32	NUM
admet-1513	135	19	6	6	NUM
admet-1513	135	20	after	after	SCONJ
admet-1513	135	21	the	the	DET
admet-1513	135	22	drug	drug	NOUN
admet-1513	135	23	is	be	AUX
admet-1513	135	24	absorbed	absorb	VERB
admet-1513	135	25	through	through	ADP
admet-1513	135	26	the	the	DET
admet-1513	135	27	intestine	intestine	NOUN
admet-1513	135	28	,	,	PUNCT
admet-1513	135	29	it	it	PRON
admet-1513	135	30	passes	pass	VERB
admet-1513	135	31	to	to	ADP
admet-1513	135	32	the	the	DET
admet-1513	135	33	liver	liver	NOUN
admet-1513	135	34	through	through	ADP
admet-1513	135	35	the	the	DET
admet-1513	135	36	hepatic	hepatic	ADJ
admet-1513	135	37	portal	portal	ADJ
admet-1513	135	38	system	system	NOUN
admet-1513	135	39	,	,	PUNCT
admet-1513	135	40	where	where	SCONJ
admet-1513	135	41	most	most	ADJ
admet-1513	135	42	of	of	ADP
admet-1513	135	43	the	the	DET
admet-1513	135	44	metabolism	metabolism	NOUN
admet-1513	135	45	happens	happen	VERB
admet-1513	135	46	.	.	PUNCT
admet-1513	136	1	the	the	DET
admet-1513	136	2	liver	liver	NOUN
admet-1513	136	3	is	be	AUX
admet-1513	136	4	the	the	DET
admet-1513	136	5	most	most	ADV
admet-1513	136	6	important	important	ADJ
admet-1513	136	7	organ	organ	NOUN
admet-1513	136	8	for	for	ADP
admet-1513	136	9	drug	drug	NOUN
admet-1513	136	10	development	development	NOUN
admet-1513	136	11	and	and	CCONJ
admet-1513	136	12	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	136	13	studies	study	NOUN
admet-1513	136	14	.	.	PUNCT
admet-1513	137	1	it	it	PRON
admet-1513	137	2	helps	help	VERB
admet-1513	137	3	in	in	ADP
admet-1513	137	4	the	the	DET
admet-1513	137	5	elimination	elimination	NOUN
admet-1513	137	6	of	of	ADP
admet-1513	137	7	many	many	ADJ
admet-1513	137	8	endogenous	endogenous	ADJ
admet-1513	137	9	and	and	CCONJ
admet-1513	137	10	exogenous	exogenous	ADJ
admet-1513	137	11	substances	substance	NOUN
admet-1513	137	12	from	from	ADP
admet-1513	137	13	the	the	DET
admet-1513	137	14	body	body	NOUN
admet-1513	137	15	through	through	ADP
admet-1513	137	16	drug	drug	NOUN
admet-1513	137	17	-	-	PUNCT
admet-1513	137	18	related	relate	VERB
admet-1513	137	19	transporters	transporter	NOUN
admet-1513	137	20	and	and	CCONJ
admet-1513	137	21	phase	phase	NOUN
admet-1513	137	22	-	-	PUNCT
admet-1513	137	23	i	i	NOUN
admet-1513	137	24	and	and	CCONJ
admet-1513	137	25	phase	phase	NOUN
admet-1513	137	26	-	-	PUNCT
admet-1513	137	27	ii	ii	NOUN
admet-1513	137	28	metabolizing	metabolize	VERB
admet-1513	137	29	enzymes	enzyme	NOUN
admet-1513	137	30	[	[	X
admet-1513	137	31	51	51	NUM
admet-1513	137	32	]	]	PUNCT
admet-1513	137	33	.	.	PUNCT
admet-1513	138	1	liver	liver	NOUN
admet-1513	138	2	models	model	NOUN
admet-1513	138	3	are	be	AUX
admet-1513	138	4	necessary	necessary	ADJ
admet-1513	138	5	for	for	ADP
admet-1513	138	6	understanding	understand	VERB
admet-1513	138	7	the	the	DET
admet-1513	138	8	metabolic	metabolic	NOUN
admet-1513	138	9	route	route	NOUN
admet-1513	138	10	,	,	PUNCT
admet-1513	138	11	identification	identification	NOUN
admet-1513	138	12	of	of	ADP
admet-1513	138	13	metabolizing	metabolize	VERB
admet-1513	138	14	enzymes	enzyme	NOUN
admet-1513	138	15	and	and	CCONJ
admet-1513	138	16	their	their	PRON
admet-1513	138	17	intermediates	intermediate	NOUN
admet-1513	138	18	and	and	CCONJ
admet-1513	138	19	final	final	ADJ
admet-1513	138	20	metabolites	metabolite	NOUN
admet-1513	138	21	,	,	PUNCT
admet-1513	138	22	transport	transport	NOUN
admet-1513	138	23	,	,	PUNCT
admet-1513	138	24	and	and	CCONJ
admet-1513	138	25	other	other	ADJ
admet-1513	138	26	drug	drug	NOUN
admet-1513	138	27	interactions	interaction	NOUN
admet-1513	138	28	,	,	PUNCT
admet-1513	138	29	as	as	SCONJ
admet-1513	138	30	it	it	PRON
admet-1513	138	31	is	be	AUX
admet-1513	138	32	responsible	responsible	ADJ
admet-1513	138	33	for	for	ADP
admet-1513	138	34	the	the	DET
admet-1513	138	35	formation	formation	NOUN
admet-1513	138	36	of	of	ADP
admet-1513	138	37	drug	drug	NOUN
admet-1513	138	38	metabolites	metabolite	NOUN
admet-1513	138	39	and	and	CCONJ
admet-1513	138	40	contribute	contribute	VERB
admet-1513	138	41	to	to	ADP
admet-1513	138	42	drug	drug	NOUN
admet-1513	138	43	clearance	clearance	NOUN
admet-1513	138	44	and	and	CCONJ
admet-1513	138	45	bioavailability	bioavailability	NOUN
admet-1513	138	46	[	[	X
admet-1513	138	47	52	52	NUM
admet-1513	138	48	]	]	PUNCT
admet-1513	138	49	.	.	PUNCT
admet-1513	139	1	these	these	DET
admet-1513	139	2	models	model	NOUN
admet-1513	139	3	are	be	AUX
admet-1513	139	4	also	also	ADV
admet-1513	139	5	necessary	necessary	ADJ
admet-1513	139	6	for	for	ADP
admet-1513	139	7	understanding	understand	VERB
admet-1513	139	8	drug	drug	NOUN
admet-1513	139	9	-	-	PUNCT
admet-1513	139	10	induced	induce	VERB
admet-1513	139	11	liver	liver	NOUN
admet-1513	139	12	injury	injury	NOUN
admet-1513	139	13	(	(	PUNCT
admet-1513	139	14	dili	dili	PROPN
admet-1513	139	15	)	)	PUNCT
admet-1513	139	16	,	,	PUNCT
admet-1513	139	17	as	as	SCONJ
admet-1513	139	18	most	most	ADJ
admet-1513	139	19	of	of	ADP
admet-1513	139	20	the	the	DET
admet-1513	139	21	drug	drug	NOUN
admet-1513	139	22	resides	reside	VERB
admet-1513	139	23	in	in	ADP
admet-1513	139	24	the	the	DET
admet-1513	139	25	liver	liver	NOUN
admet-1513	139	26	.	.	PUNCT
admet-1513	140	1	to	to	PART
admet-1513	140	2	address	address	VERB
admet-1513	140	3	this	this	DET
admet-1513	140	4	barrier	barrier	NOUN
admet-1513	140	5	issue	issue	NOUN
admet-1513	140	6	in	in	ADP
admet-1513	140	7	orally	orally	ADV
admet-1513	140	8	administered	administer	VERB
admet-1513	140	9	drugs	drug	NOUN
admet-1513	140	10	,	,	PUNCT
admet-1513	140	11	researchers	researcher	NOUN
admet-1513	140	12	have	have	AUX
admet-1513	140	13	developed	develop	VERB
admet-1513	140	14	hepatic	hepatic	ADJ
admet-1513	140	15	metabolic	metabolic	NOUN
admet-1513	140	16	stability	stability	NOUN
admet-1513	140	17	assays	assay	NOUN
admet-1513	140	18	and	and	CCONJ
admet-1513	140	19	hepatic	hepatic	ADJ
admet-1513	140	20	metabolism	metabolism	NOUN
admet-1513	140	21	by	by	ADP
admet-1513	140	22	cytochrome	cytochrome	ADJ
admet-1513	140	23	p450	p450	PROPN
admet-1513	140	24	(	(	PUNCT
admet-1513	140	25	cyp	cyp	ADJ
admet-1513	140	26	)	)	PUNCT
admet-1513	140	27	enzymes	enzyme	NOUN
admet-1513	140	28	.	.	PUNCT
admet-1513	141	1	these	these	DET
admet-1513	141	2	assays	assay	NOUN
admet-1513	141	3	are	be	AUX
admet-1513	141	4	very	very	ADV
admet-1513	141	5	useful	useful	ADJ
admet-1513	141	6	in	in	ADP
admet-1513	141	7	finding	find	VERB
admet-1513	141	8	apparent	apparent	ADJ
admet-1513	141	9	clearance	clearance	NOUN
admet-1513	141	10	(	(	PUNCT
admet-1513	141	11	clapp	clapp	PROPN
admet-1513	141	12	)	)	PUNCT
admet-1513	141	13	,	,	PUNCT
admet-1513	141	14	in	in	ADP
admet-1513	141	15	vitro	vitro	ADJ
admet-1513	141	16	half	half	ADJ
admet-1513	141	17	-	-	PUNCT
admet-1513	141	18	life	life	NOUN
admet-1513	141	19	(	(	PUNCT
admet-1513	141	20	t1/2	t1/2	NOUN
admet-1513	141	21	)	)	PUNCT
admet-1513	141	22	for	for	ADP
admet-1513	141	23	early	early	ADJ
admet-1513	141	24	screening	screening	NOUN
admet-1513	141	25	and	and	CCONJ
admet-1513	141	26	for	for	ADP
admet-1513	141	27	ranking	rank	VERB
admet-1513	141	28	the	the	DET
admet-1513	141	29	drug	drug	NOUN
admet-1513	141	30	candidates	candidate	NOUN
admet-1513	141	31	and	and	CCONJ
admet-1513	141	32	revealing	reveal	VERB
admet-1513	141	33	information	information	NOUN
admet-1513	141	34	about	about	ADP
admet-1513	141	35	the	the	DET
admet-1513	141	36	possibility	possibility	NOUN
admet-1513	141	37	of	of	ADP
admet-1513	141	38	the	the	DET
admet-1513	141	39	drug	drug	NOUN
admet-1513	141	40	exposure	exposure	NOUN
admet-1513	141	41	variability	variability	NOUN
admet-1513	141	42	due	due	ADP
admet-1513	141	43	to	to	ADP
admet-1513	141	44	metabolism	metabolism	NOUN
admet-1513	141	45	by	by	ADP
admet-1513	141	46	polymorphic	polymorphic	ADJ
admet-1513	141	47	enzymes	enzyme	NOUN
admet-1513	141	48	,	,	PUNCT
admet-1513	141	49	comparative	comparative	ADJ
admet-1513	141	50	metabolite	metabolite	NOUN
admet-1513	141	51	fate	fate	NOUN
admet-1513	141	52	between	between	ADP
admet-1513	141	53	preclinical	preclinical	ADJ
admet-1513	141	54	animals	animal	NOUN
admet-1513	141	55	to	to	ADP
admet-1513	141	56	that	that	PRON
admet-1513	141	57	of	of	ADP
admet-1513	141	58	human	human	ADJ
admet-1513	141	59	and	and	CCONJ
admet-1513	141	60	also	also	ADV
admet-1513	141	61	clinical	clinical	ADJ
admet-1513	141	62	interactions	interaction	NOUN
admet-1513	141	63	because	because	SCONJ
admet-1513	141	64	of	of	ADP
admet-1513	141	65	inhibition	inhibition	NOUN
admet-1513	141	66	or	or	CCONJ
admet-1513	141	67	induction	induction	NOUN
admet-1513	141	68	[	[	X
admet-1513	141	69	53	53	NUM
admet-1513	141	70	]	]	PUNCT
admet-1513	141	71	.	.	PUNCT
admet-1513	142	1	the	the	DET
admet-1513	142	2	cyp450	cyp450	NOUN
admet-1513	142	3	family	family	NOUN
admet-1513	142	4	is	be	AUX
admet-1513	142	5	the	the	DET
admet-1513	142	6	major	major	ADJ
admet-1513	142	7	target	target	NOUN
admet-1513	142	8	of	of	ADP
admet-1513	142	9	the	the	DET
admet-1513	142	10	liver	liver	NOUN
admet-1513	142	11	’s	’s	PART
admet-1513	142	12	metabolic	metabolic	NOUN
admet-1513	142	13	activity	activity	NOUN
admet-1513	142	14	,	,	PUNCT
admet-1513	142	15	which	which	PRON
admet-1513	142	16	metabolizes	metabolize	VERB
admet-1513	142	17	a	a	DET
admet-1513	142	18	wide	wide	ADJ
admet-1513	142	19	range	range	NOUN
admet-1513	142	20	of	of	ADP
admet-1513	142	21	drugs	drug	NOUN
admet-1513	142	22	.	.	PUNCT
admet-1513	143	1	among	among	ADP
admet-1513	143	2	~50	~50	ADP
admet-1513	143	3	cyp	cyp	ADJ
admet-1513	143	4	isoforms	isoform	NOUN
admet-1513	143	5	,	,	PUNCT
admet-1513	143	6	cyp3a4	cyp3a4	NOUN
admet-1513	143	7	accounts	account	VERB
admet-1513	143	8	for	for	ADP
admet-1513	143	9	around	around	ADV
admet-1513	143	10	50	50	NUM
admet-1513	143	11	-	-	SYM
admet-1513	143	12	60	60	NUM
admet-1513	143	13	%	%	NOUN
admet-1513	143	14	of	of	ADP
admet-1513	143	15	all	all	DET
admet-1513	143	16	therapeutic	therapeutic	ADJ
admet-1513	143	17	drugs	drug	NOUN
admet-1513	143	18	[	[	X
admet-1513	143	19	54	54	NUM
admet-1513	143	20	]	]	PUNCT
admet-1513	143	21	.	.	PUNCT
admet-1513	144	1	cyp	cyp	ADJ
admet-1513	144	2	inhibition	inhibition	NOUN
admet-1513	144	3	assay	assay	NOUN
admet-1513	144	4	has	have	AUX
admet-1513	144	5	become	become	VERB
admet-1513	144	6	an	an	DET
admet-1513	144	7	important	important	ADJ
admet-1513	144	8	determinant	determinant	ADJ
admet-1513	144	9	in	in	ADP
admet-1513	144	10	the	the	DET
admet-1513	144	11	discovery	discovery	NOUN
admet-1513	144	12	and	and	CCONJ
admet-1513	144	13	development	development	NOUN
admet-1513	144	14	of	of	ADP
admet-1513	144	15	new	new	ADJ
admet-1513	144	16	drugs	drug	NOUN
admet-1513	144	17	as	as	SCONJ
admet-1513	144	18	they	they	PRON
admet-1513	144	19	provide	provide	VERB
admet-1513	144	20	valuable	valuable	ADJ
admet-1513	144	21	information	information	NOUN
admet-1513	144	22	about	about	ADP
admet-1513	144	23	drug	drug	NOUN
admet-1513	144	24	exposure	exposure	NOUN
admet-1513	144	25	potential	potential	NOUN
admet-1513	144	26	and	and	CCONJ
admet-1513	144	27	metabolite	metabolite	NOUN
admet-1513	144	28	fate	fate	NOUN
admet-1513	144	29	among	among	ADP
admet-1513	144	30	preclinical	preclinical	ADJ
admet-1513	144	31	species	specie	NOUN
admet-1513	144	32	to	to	ADP
admet-1513	144	33	that	that	PRON
admet-1513	144	34	of	of	ADP
admet-1513	144	35	humans	human	NOUN
admet-1513	144	36	as	as	ADV
admet-1513	144	37	well	well	ADV
admet-1513	144	38	as	as	ADP
admet-1513	144	39	clinical	clinical	ADJ
admet-1513	144	40	interactions	interaction	NOUN
admet-1513	144	41	caused	cause	VERB
admet-1513	144	42	by	by	ADP
admet-1513	144	43	inhibition	inhibition	NOUN
admet-1513	144	44	and	and	CCONJ
admet-1513	144	45	induction	induction	NOUN
admet-1513	145	1	[	[	X
admet-1513	145	2	55	55	NUM
admet-1513	145	3	]	]	PUNCT
admet-1513	145	4	.	.	PUNCT
admet-1513	146	1	hepatic	hepatic	ADJ
admet-1513	146	2	metabolism	metabolism	NOUN
admet-1513	146	3	occurs	occur	VERB
admet-1513	146	4	in	in	ADP
admet-1513	146	5	two	two	NUM
admet-1513	146	6	phases	phase	NOUN
admet-1513	146	7	.	.	PUNCT
admet-1513	147	1	in	in	ADP
admet-1513	147	2	phase	phase	NOUN
admet-1513	147	3	-	-	PUNCT
admet-1513	147	4	i	i	NOUN
admet-1513	147	5	,	,	PUNCT
admet-1513	147	6	structural	structural	ADJ
admet-1513	147	7	alterations	alteration	NOUN
admet-1513	147	8	in	in	ADP
admet-1513	147	9	drug	drug	NOUN
admet-1513	147	10	molecules	molecule	NOUN
admet-1513	147	11	occur	occur	VERB
admet-1513	147	12	,	,	PUNCT
admet-1513	147	13	while	while	SCONJ
admet-1513	147	14	in	in	ADP
admet-1513	147	15	phaseii	phaseii	PROPN
admet-1513	147	16	,	,	PUNCT
admet-1513	147	17	the	the	DET
admet-1513	147	18	association	association	NOUN
admet-1513	147	19	of	of	ADP
admet-1513	147	20	drugs	drug	NOUN
admet-1513	147	21	with	with	ADP
admet-1513	147	22	hydrophilic	hydrophilic	ADJ
admet-1513	147	23	chemical	chemical	NOUN
admet-1513	147	24	moiety	moiety	NOUN
admet-1513	147	25	is	be	AUX
admet-1513	147	26	mediated	mediate	VERB
admet-1513	147	27	by	by	ADP
admet-1513	147	28	various	various	ADJ
admet-1513	147	29	transferases	transferase	NOUN
admet-1513	147	30	such	such	ADJ
admet-1513	147	31	as	as	ADP
admet-1513	147	32	udpglucuronosyltransferases	udpglucuronosyltransferase	NOUN
admet-1513	147	33	(	(	PUNCT
admet-1513	147	34	ugt	ugt	NOUN
admet-1513	147	35	)	)	PUNCT
admet-1513	147	36	and	and	CCONJ
admet-1513	147	37	gsts	gst	NOUN
admet-1513	147	38	,	,	PUNCT
admet-1513	147	39	yielding	yield	VERB
admet-1513	147	40	the	the	DET
admet-1513	147	41	production	production	NOUN
admet-1513	147	42	of	of	ADP
admet-1513	147	43	more	more	ADJ
admet-1513	147	44	polar	polar	ADJ
admet-1513	147	45	metabolites	metabolite	NOUN
admet-1513	147	46	.	.	PUNCT
admet-1513	148	1	phase	phase	NOUN
admet-1513	148	2	-	-	PUNCT
admet-1513	148	3	ii	ii	NOUN
admet-1513	148	4	metabolism	metabolism	NOUN
admet-1513	148	5	is	be	AUX
admet-1513	148	6	responsible	responsible	ADJ
admet-1513	148	7	for	for	ADP
admet-1513	148	8	the	the	DET
admet-1513	148	9	detoxification	detoxification	NOUN
admet-1513	148	10	of	of	ADP
admet-1513	148	11	metabolites	metabolite	NOUN
admet-1513	148	12	produced	produce	VERB
admet-1513	148	13	in	in	ADP
admet-1513	148	14	phase	phase	NOUN
admet-1513	148	15	i	i	PRON
admet-1513	148	16	metabolism	metabolism	VERB
admet-1513	149	1	[	[	X
admet-1513	149	2	56	56	NUM
admet-1513	149	3	]	]	PUNCT
admet-1513	149	4	.	.	PUNCT
admet-1513	150	1	other	other	ADJ
admet-1513	150	2	than	than	ADP
admet-1513	150	3	cyp	cyp	ADJ
admet-1513	150	4	metabolism	metabolism	NOUN
admet-1513	150	5	,	,	PUNCT
admet-1513	150	6	several	several	ADJ
admet-1513	150	7	other	other	ADJ
admet-1513	150	8	in	in	ADP
admet-1513	150	9	vitro	vitro	X
admet-1513	150	10	models	model	NOUN
admet-1513	150	11	have	have	AUX
admet-1513	150	12	been	be	AUX
admet-1513	150	13	established	establish	VERB
admet-1513	150	14	for	for	ADP
admet-1513	150	15	studying	study	VERB
admet-1513	150	16	hepatic	hepatic	ADJ
admet-1513	150	17	metabolism	metabolism	NOUN
admet-1513	150	18	.	.	PUNCT
admet-1513	151	1	these	these	PRON
admet-1513	151	2	include	include	VERB
admet-1513	151	3	primary	primary	ADJ
admet-1513	151	4	hepatocytes	hepatocyte	NOUN
admet-1513	151	5	,	,	PUNCT
admet-1513	151	6	hepatic	hepatic	ADJ
admet-1513	151	7	cell	cell	NOUN
admet-1513	151	8	lines	line	NOUN
admet-1513	151	9	,	,	PUNCT
admet-1513	151	10	precision	precision	NOUN
admet-1513	151	11	-	-	PUNCT
admet-1513	151	12	cut	cut	VERB
admet-1513	151	13	liver	liver	NOUN
admet-1513	151	14	slices	slice	NOUN
admet-1513	151	15	and	and	CCONJ
admet-1513	151	16	microsomes	microsome	NOUN
admet-1513	151	17	.	.	PUNCT
admet-1513	152	1	due	due	ADP
admet-1513	152	2	to	to	ADP
admet-1513	152	3	limitations	limitation	NOUN
admet-1513	152	4	in	in	ADP
admet-1513	152	5	the	the	DET
admet-1513	152	6	use	use	NOUN
admet-1513	152	7	of	of	ADP
admet-1513	152	8	these	these	DET
admet-1513	152	9	models	model	NOUN
admet-1513	152	10	,	,	PUNCT
admet-1513	152	11	such	such	ADJ
admet-1513	152	12	as	as	ADP
admet-1513	152	13	loss	loss	NOUN
admet-1513	152	14	of	of	ADP
admet-1513	152	15	cell	cell	NOUN
admet-1513	152	16	specificity	specificity	NOUN
admet-1513	152	17	and	and	CCONJ
admet-1513	152	18	limited	limited	ADJ
admet-1513	152	19	life	life	NOUN
admet-1513	152	20	span	span	NOUN
admet-1513	152	21	,	,	PUNCT
admet-1513	152	22	primary	primary	ADJ
admet-1513	152	23	hepatocyte	hepatocyte	NOUN
admet-1513	152	24	cultures	culture	NOUN
admet-1513	152	25	from	from	ADP
admet-1513	152	26	different	different	ADJ
admet-1513	152	27	species	specie	NOUN
admet-1513	152	28	become	become	VERB
admet-1513	152	29	the	the	DET
admet-1513	152	30	preferred	preferred	ADJ
admet-1513	152	31	model	model	NOUN
admet-1513	152	32	for	for	ADP
admet-1513	152	33	conducting	conduct	VERB
admet-1513	152	34	in	in	ADP
admet-1513	152	35	vitro	vitro	X
admet-1513	152	36	toxicity	toxicity	NOUN
admet-1513	152	37	and	and	CCONJ
admet-1513	152	38	metabolic	metabolic	NOUN
admet-1513	152	39	research	research	NOUN
admet-1513	152	40	[	[	X
admet-1513	152	41	57,58	57,58	NUM
admet-1513	152	42	]	]	PUNCT
admet-1513	152	43	.	.	PUNCT
admet-1513	153	1	primary	primary	ADJ
admet-1513	153	2	hepatocytes	hepatocyte	NOUN
admet-1513	153	3	primary	primary	ADJ
admet-1513	153	4	hepatocytes	hepatocyte	NOUN
admet-1513	153	5	collected	collect	VERB
admet-1513	153	6	from	from	ADP
admet-1513	153	7	different	different	ADJ
admet-1513	153	8	species	specie	NOUN
admet-1513	153	9	like	like	ADP
admet-1513	153	10	mouse	mouse	NOUN
admet-1513	153	11	rats	rat	NOUN
admet-1513	153	12	and	and	CCONJ
admet-1513	153	13	humans	human	NOUN
admet-1513	153	14	are	be	AUX
admet-1513	153	15	widely	widely	ADV
admet-1513	153	16	used	use	VERB
admet-1513	153	17	for	for	ADP
admet-1513	153	18	studying	study	VERB
admet-1513	153	19	in	in	ADP
admet-1513	153	20	vitro	vitro	X
admet-1513	153	21	hepatic	hepatic	ADJ
admet-1513	153	22	clearance	clearance	NOUN
admet-1513	153	23	and	and	CCONJ
admet-1513	153	24	in	in	ADP
admet-1513	153	25	vivo	vivo	ADJ
admet-1513	153	26	prediction	prediction	NOUN
admet-1513	154	1	[	[	X
admet-1513	154	2	59	59	NUM
admet-1513	154	3	-	-	SYM
admet-1513	154	4	61	61	NUM
admet-1513	154	5	]	]	PUNCT
admet-1513	154	6	.	.	PUNCT
admet-1513	155	1	the	the	DET
admet-1513	155	2	major	major	ADJ
admet-1513	155	3	advantage	advantage	NOUN
admet-1513	155	4	of	of	ADP
admet-1513	155	5	using	use	VERB
admet-1513	155	6	this	this	DET
admet-1513	155	7	model	model	NOUN
admet-1513	155	8	is	be	AUX
admet-1513	155	9	the	the	DET
admet-1513	155	10	availability	availability	NOUN
admet-1513	155	11	of	of	ADP
admet-1513	155	12	a	a	DET
admet-1513	155	13	full	full	ADJ
admet-1513	155	14	set	set	NOUN
admet-1513	155	15	of	of	ADP
admet-1513	155	16	enzymes	enzyme	NOUN
admet-1513	155	17	and	and	CCONJ
admet-1513	155	18	cofactors	cofactor	NOUN
admet-1513	155	19	in	in	ADP
admet-1513	155	20	their	their	PRON
admet-1513	155	21	physiological	physiological	ADJ
admet-1513	155	22	conditions	condition	NOUN
admet-1513	155	23	[	[	X
admet-1513	155	24	62,63	62,63	NOUN
admet-1513	155	25	]	]	PUNCT
admet-1513	155	26	.	.	PUNCT
admet-1513	156	1	human	human	ADJ
admet-1513	156	2	hepatocytes	hepatocyte	NOUN
admet-1513	156	3	have	have	VERB
admet-1513	156	4	a	a	DET
admet-1513	156	5	distinct	distinct	ADJ
admet-1513	156	6	advantage	advantage	NOUN
admet-1513	156	7	,	,	PUNCT
admet-1513	156	8	providing	provide	VERB
admet-1513	156	9	almost	almost	ADV
admet-1513	156	10	similar	similar	ADJ
admet-1513	156	11	drug	drug	NOUN
admet-1513	156	12	metabolic	metabolic	NOUN
admet-1513	156	13	profiles	profile	NOUN
admet-1513	156	14	in	in	ADP
admet-1513	156	15	vivo	vivo	NOUN
admet-1513	156	16	.	.	PUNCT
admet-1513	157	1	but	but	CCONJ
admet-1513	157	2	the	the	DET
admet-1513	157	3	major	major	ADJ
admet-1513	157	4	limitations	limitation	NOUN
admet-1513	157	5	are	be	AUX
admet-1513	157	6	the	the	DET
admet-1513	157	7	availability	availability	NOUN
admet-1513	157	8	of	of	ADP
admet-1513	157	9	liver	liver	NOUN
admet-1513	157	10	donors	donor	NOUN
admet-1513	157	11	,	,	PUNCT
admet-1513	157	12	the	the	DET
admet-1513	157	13	disease	disease	NOUN
admet-1513	157	14	status	status	NOUN
admet-1513	157	15	of	of	ADP
admet-1513	157	16	the	the	DET
admet-1513	157	17	liver	liver	NOUN
admet-1513	157	18	and	and	CCONJ
admet-1513	157	19	person	person	NOUN
admet-1513	157	20	-	-	PUNCT
admet-1513	157	21	to	to	ADP
admet-1513	157	22	-	-	PUNCT
admet-1513	157	23	person	person	NOUN
admet-1513	157	24	diversity	diversity	NOUN
admet-1513	157	25	.	.	PUNCT
admet-1513	158	1	moreover	moreover	ADV
admet-1513	158	2	,	,	PUNCT
admet-1513	158	3	individual	individual	ADJ
admet-1513	158	4	variations	variation	NOUN
admet-1513	158	5	in	in	ADP
admet-1513	158	6	cyp	cyp	ADJ
admet-1513	158	7	expression	expression	NOUN
admet-1513	158	8	and	and	CCONJ
admet-1513	158	9	activity	activity	NOUN
admet-1513	158	10	were	be	AUX
admet-1513	158	11	already	already	ADV
admet-1513	158	12	reported	report	VERB
admet-1513	158	13	because	because	SCONJ
admet-1513	158	14	of	of	ADP
admet-1513	158	15	lifestyle	lifestyle	NOUN
admet-1513	158	16	differences	difference	NOUN
admet-1513	158	17	,	,	PUNCT
admet-1513	158	18	age	age	NOUN
admet-1513	158	19	group	group	NOUN
admet-1513	158	20	and	and	CCONJ
admet-1513	158	21	hormonal	hormonal	ADJ
admet-1513	158	22	status	status	NOUN
admet-1513	158	23	that	that	PRON
admet-1513	158	24	affect	affect	VERB
admet-1513	158	25	the	the	DET
admet-1513	158	26	hepatocytes	hepatocyte	NOUN
admet-1513	158	27	'	'	PART
admet-1513	158	28	activity	activity	NOUN
admet-1513	158	29	[	[	X
admet-1513	158	30	64	64	NUM
admet-1513	158	31	]	]	PUNCT
admet-1513	158	32	.	.	PUNCT
admet-1513	159	1	since	since	SCONJ
admet-1513	159	2	freshly	freshly	ADV
admet-1513	159	3	collected	collect	VERB
admet-1513	159	4	hepatocytes	hepatocyte	NOUN
admet-1513	159	5	are	be	AUX
admet-1513	159	6	difficult	difficult	ADJ
admet-1513	159	7	to	to	PART
admet-1513	159	8	obtain	obtain	VERB
admet-1513	159	9	,	,	PUNCT
admet-1513	159	10	several	several	ADJ
admet-1513	159	11	cryo	cryo	NOUN
admet-1513	159	12	-	-	PUNCT
admet-1513	159	13	preservation	preservation	NOUN
admet-1513	159	14	methods	method	NOUN
admet-1513	159	15	have	have	AUX
admet-1513	159	16	been	be	AUX
admet-1513	159	17	developed	develop	VERB
admet-1513	159	18	by	by	ADP
admet-1513	159	19	researchers	researcher	NOUN
admet-1513	159	20	for	for	ADP
admet-1513	159	21	long	long	ADJ
admet-1513	159	22	-	-	PUNCT
admet-1513	159	23	duration	duration	NOUN
admet-1513	159	24	storage	storage	NOUN
admet-1513	159	25	and	and	CCONJ
admet-1513	159	26	supply	supply	NOUN
admet-1513	159	27	without	without	ADP
admet-1513	159	28	any	any	DET
admet-1513	159	29	changes	change	NOUN
admet-1513	159	30	in	in	ADP
admet-1513	159	31	differentiated	differentiated	ADJ
admet-1513	159	32	form	form	NOUN
admet-1513	159	33	or	or	CCONJ
admet-1513	159	34	activity	activity	NOUN
admet-1513	159	35	[	[	X
admet-1513	159	36	65	65	NUM
admet-1513	159	37	]	]	PUNCT
admet-1513	159	38	.	.	PUNCT
admet-1513	160	1	sandwich	sandwich	NOUN
admet-1513	160	2	culturing	culture	VERB
admet-1513	160	3	primary	primary	ADJ
admet-1513	160	4	hepatocytes	hepatocyte	NOUN
admet-1513	160	5	(	(	PUNCT
admet-1513	160	6	sch	sch	INTJ
admet-1513	160	7	)	)	PUNCT
admet-1513	160	8	between	between	ADP
admet-1513	160	9	collagen	collagen	NOUN
admet-1513	160	10	matrixes	matrix	NOUN
admet-1513	160	11	is	be	AUX
admet-1513	160	12	an	an	DET
admet-1513	160	13	alternative	alternative	ADJ
admet-1513	160	14	approach	approach	NOUN
admet-1513	160	15	commonly	commonly	ADV
admet-1513	160	16	used	use	VERB
admet-1513	160	17	for	for	ADP
admet-1513	160	18	assessing	assess	VERB
admet-1513	160	19	drug	drug	NOUN
admet-1513	160	20	metabolism	metabolism	NOUN
admet-1513	160	21	[	[	X
admet-1513	160	22	66	66	NUM
admet-1513	160	23	]	]	PUNCT
admet-1513	160	24	.	.	PUNCT
admet-1513	161	1	compared	compare	VERB
admet-1513	161	2	to	to	ADP
admet-1513	161	3	monolayers	monolayer	NOUN
admet-1513	161	4	,	,	PUNCT
admet-1513	161	5	sch	sch	PROPN
admet-1513	161	6	showed	show	VERB
admet-1513	161	7	functional	functional	ADJ
admet-1513	161	8	integrity	integrity	NOUN
admet-1513	161	9	,	,	PUNCT
admet-1513	161	10	continuous	continuous	ADJ
admet-1513	161	11	release	release	NOUN
admet-1513	161	12	of	of	ADP
admet-1513	161	13	albumin	albumin	ADJ
admet-1513	161	14	and	and	CCONJ
admet-1513	161	15	stable	stable	ADJ
admet-1513	161	16	cyp	cyp	ADJ
admet-1513	161	17	expression	expression	NOUN
admet-1513	161	18	for	for	ADP
admet-1513	161	19	long	long	ADJ
admet-1513	161	20	durations	duration	NOUN
admet-1513	161	21	[	[	X
admet-1513	161	22	66	66	NUM
admet-1513	161	23	-	-	SYM
admet-1513	161	24	68	68	NUM
admet-1513	161	25	]	]	PUNCT
admet-1513	161	26	.	.	PUNCT
admet-1513	162	1	moreover	moreover	ADV
admet-1513	162	2	,	,	PUNCT
admet-1513	162	3	these	these	DET
admet-1513	162	4	models	model	NOUN
admet-1513	162	5	resemble	resemble	VERB
admet-1513	162	6	the	the	DET
admet-1513	162	7	in	in	ADP
admet-1513	162	8	vivo	vivo	ADJ
admet-1513	162	9	conditions	condition	NOUN
admet-1513	162	10	like	like	ADP
admet-1513	162	11	the	the	DET
admet-1513	162	12	polarized	polarize	VERB
admet-1513	162	13	expression	expression	NOUN
admet-1513	162	14	of	of	ADP
admet-1513	162	15	transporters	transporter	NOUN
admet-1513	162	16	in	in	ADP
admet-1513	162	17	apical	apical	ADJ
admet-1513	162	18	and	and	CCONJ
admet-1513	162	19	basolateral	basolateral	ADJ
admet-1513	162	20	membranes	membrane	NOUN
admet-1513	162	21	,	,	PUNCT
admet-1513	162	22	thus	thus	ADV
admet-1513	162	23	providing	provide	VERB
admet-1513	162	24	a	a	DET
admet-1513	162	25	major	major	ADJ
admet-1513	162	26	advantage	advantage	NOUN
admet-1513	162	27	for	for	ADP
admet-1513	162	28	studying	study	VERB
admet-1513	162	29	transport	transport	NOUN
admet-1513	162	30	and	and	CCONJ
admet-1513	162	31	metabolism	metabolism	NOUN
admet-1513	162	32	admet	admet	PROPN
admet-1513	162	33	&	&	CCONJ
admet-1513	162	34	dmpk	dmpk	PROPN
admet-1513	162	35	11(1	11(1	NUM
admet-1513	162	36	)	)	PUNCT
admet-1513	162	37	(	(	PUNCT
admet-1513	162	38	2023	2023	NUM
admet-1513	162	39	)	)	PUNCT
admet-1513	162	40	1	1	NUM
admet-1513	162	41	-	-	SYM
admet-1513	162	42	32	32	NUM
admet-1513	162	43	2d	2d	NOUN
admet-1513	162	44	and	and	CCONJ
admet-1513	162	45	3d	3d	NOUN
admet-1513	162	46	adme	adme	PROPN
admet-1513	162	47	-	-	PUNCT
admet-1513	162	48	tox	tox	NOUN
admet-1513	162	49	cell	cell	NOUN
admet-1513	162	50	culture	culture	NOUN
admet-1513	162	51	screening	screen	VERB
admet-1513	162	52	:	:	PUNCT
admet-1513	162	53	a	a	DET
admet-1513	162	54	review	review	NOUN
admet-1513	162	55	doi	doi	NOUN
admet-1513	162	56	:	:	PUNCT
admet-1513	162	57	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	162	58	7	7	NUM
admet-1513	162	59	simultaneously	simultaneously	ADV
admet-1513	162	60	[	[	X
admet-1513	162	61	69	69	NUM
admet-1513	162	62	]	]	PUNCT
admet-1513	162	63	.	.	PUNCT
admet-1513	163	1	application	application	NOUN
admet-1513	163	2	of	of	ADP
admet-1513	163	3	these	these	DET
admet-1513	163	4	sch	sch	PROPN
admet-1513	163	5	models	model	NOUN
admet-1513	163	6	includes	include	VERB
admet-1513	163	7	:	:	PUNCT
admet-1513	163	8	understanding	understand	VERB
admet-1513	163	9	the	the	DET
admet-1513	163	10	interactions	interaction	NOUN
admet-1513	163	11	between	between	ADP
admet-1513	163	12	membrane	membrane	NOUN
admet-1513	163	13	transporters	transporter	NOUN
admet-1513	163	14	and	and	CCONJ
admet-1513	163	15	metabolizing	metabolize	VERB
admet-1513	163	16	enzymes	enzyme	NOUN
admet-1513	163	17	because	because	SCONJ
admet-1513	163	18	they	they	PRON
admet-1513	163	19	play	play	VERB
admet-1513	163	20	a	a	DET
admet-1513	163	21	part	part	NOUN
admet-1513	163	22	in	in	ADP
admet-1513	163	23	restricting	restrict	VERB
admet-1513	163	24	a	a	DET
admet-1513	163	25	parent	parent	NOUN
admet-1513	163	26	drug	drug	NOUN
admet-1513	163	27	's	's	PART
admet-1513	163	28	systemic	systemic	ADJ
admet-1513	163	29	availability	availability	NOUN
admet-1513	163	30	through	through	ADP
admet-1513	163	31	metabolism	metabolism	NOUN
admet-1513	163	32	,	,	PUNCT
admet-1513	163	33	and	and	CCONJ
admet-1513	163	34	efflux	efflux	VERB
admet-1513	163	35	(	(	PUNCT
admet-1513	163	36	eg	eg	NOUN
admet-1513	163	37	.	.	PUNCT
admet-1513	163	38	gsts	gst	NOUN
admet-1513	163	39	and	and	CCONJ
admet-1513	163	40	mrp2	mrp2	PROPN
admet-1513	163	41	;	;	PUNCT
admet-1513	163	42	cyp3a	cyp3a	NOUN
admet-1513	163	43	and	and	CCONJ
admet-1513	163	44	p	p	NOUN
admet-1513	163	45	-	-	PUNCT
admet-1513	163	46	gp	gp	NOUN
admet-1513	163	47	)	)	PUNCT
admet-1513	164	1	[	[	X
admet-1513	164	2	70	70	NUM
admet-1513	164	3	]	]	PUNCT
admet-1513	164	4	.	.	PUNCT
admet-1513	165	1	to	to	PART
admet-1513	165	2	understand	understand	VERB
admet-1513	165	3	the	the	DET
admet-1513	165	4	role	role	NOUN
admet-1513	165	5	of	of	ADP
admet-1513	165	6	hepatic	hepatic	ADJ
admet-1513	165	7	transporters	transporter	NOUN
admet-1513	165	8	on	on	ADP
admet-1513	165	9	apical	apical	ADJ
admet-1513	165	10	and	and	CCONJ
admet-1513	165	11	basolateral	basolateral	ADJ
admet-1513	165	12	sides	side	NOUN
admet-1513	165	13	during	during	ADP
admet-1513	165	14	drug	drug	NOUN
admet-1513	165	15	and	and	CCONJ
admet-1513	165	16	metabolite	metabolite	NOUN
admet-1513	165	17	disposal	disposal	NOUN
admet-1513	165	18	.	.	PUNCT
admet-1513	166	1	for	for	ADP
admet-1513	166	2	example	example	NOUN
admet-1513	166	3	,	,	PUNCT
admet-1513	166	4	sodium	sodium	NOUN
admet-1513	166	5	-	-	PUNCT
admet-1513	166	6	taurocholate	taurocholate	NOUN
admet-1513	166	7	co	co	NOUN
admet-1513	166	8	-	-	ADJ
admet-1513	166	9	transporting	transporting	ADJ
admet-1513	166	10	polypeptide	polypeptide	ADJ
admet-1513	166	11	(	(	PUNCT
admet-1513	166	12	ntcp	ntcp	PROPN
admet-1513	166	13	)	)	PUNCT
admet-1513	166	14	,	,	PUNCT
admet-1513	166	15	organic	organic	ADJ
admet-1513	166	16	cation	cation	NOUN
admet-1513	166	17	transporter	transporter	NOUN
admet-1513	166	18	(	(	PUNCT
admet-1513	166	19	oct	oct	NOUN
admet-1513	166	20	)	)	PUNCT
admet-1513	166	21	,	,	PUNCT
admet-1513	166	22	and	and	CCONJ
admet-1513	166	23	organic	organic	ADJ
admet-1513	166	24	anion	anion	NOUN
admet-1513	166	25	transporting	transport	VERB
admet-1513	166	26	polypeptides	polypeptide	NOUN
admet-1513	166	27	(	(	PUNCT
admet-1513	166	28	oatp	oatp	ADJ
admet-1513	166	29	)	)	PUNCT
admet-1513	166	30	are	be	AUX
admet-1513	166	31	present	present	ADJ
admet-1513	166	32	on	on	ADP
admet-1513	166	33	the	the	DET
admet-1513	166	34	apical	apical	ADJ
admet-1513	166	35	side	side	NOUN
admet-1513	166	36	for	for	ADP
admet-1513	166	37	uptaking	uptaking	NOUN
admet-1513	166	38	of	of	ADP
admet-1513	166	39	drugs	drug	NOUN
admet-1513	166	40	from	from	ADP
admet-1513	166	41	the	the	DET
admet-1513	166	42	blood	blood	NOUN
admet-1513	166	43	to	to	ADP
admet-1513	166	44	the	the	DET
admet-1513	166	45	liver	liver	NOUN
admet-1513	166	46	and	and	CCONJ
admet-1513	166	47	multi	multi	ADJ
admet-1513	166	48	-	-	ADJ
admet-1513	166	49	drug	drug	ADJ
admet-1513	166	50	resistance	resistance	NOUN
admet-1513	166	51	(	(	PUNCT
admet-1513	166	52	mdr	mdr	PROPN
admet-1513	166	53	)	)	PUNCT
admet-1513	166	54	which	which	PRON
admet-1513	166	55	are	be	AUX
admet-1513	166	56	expressed	express	VERB
admet-1513	166	57	on	on	ADP
admet-1513	166	58	the	the	DET
admet-1513	166	59	basolateral	basolateral	ADJ
admet-1513	166	60	membrane	membrane	NOUN
admet-1513	166	61	effluxes	effluxe	VERB
admet-1513	166	62	the	the	DET
admet-1513	166	63	drug	drug	NOUN
admet-1513	166	64	or	or	CCONJ
admet-1513	166	65	metabolites	metabolite	NOUN
admet-1513	166	66	from	from	ADP
admet-1513	166	67	the	the	DET
admet-1513	166	68	liver	liver	NOUN
admet-1513	166	69	to	to	ADP
admet-1513	166	70	the	the	DET
admet-1513	166	71	blood	blood	NOUN
admet-1513	167	1	[	[	X
admet-1513	167	2	71	71	NUM
admet-1513	167	3	]	]	PUNCT
admet-1513	167	4	.	.	PUNCT
admet-1513	168	1	the	the	DET
admet-1513	168	2	other	other	ADJ
admet-1513	168	3	applications	application	NOUN
admet-1513	168	4	include	include	VERB
admet-1513	168	5	elucidating	elucidate	VERB
admet-1513	168	6	the	the	DET
admet-1513	168	7	mechanism	mechanism	NOUN
admet-1513	168	8	of	of	ADP
admet-1513	168	9	dili	dili	NOUN
admet-1513	168	10	and	and	CCONJ
admet-1513	168	11	hepatobiliary	hepatobiliary	ADJ
admet-1513	168	12	disposition	disposition	NOUN
admet-1513	168	13	[	[	X
admet-1513	168	14	72	72	NUM
admet-1513	168	15	]	]	PUNCT
admet-1513	168	16	.	.	PUNCT
admet-1513	169	1	liver	liver	NOUN
admet-1513	169	2	microsome	microsome	NOUN
admet-1513	169	3	,	,	PUNCT
admet-1513	169	4	cytosols	cytosols	ADJ
admet-1513	169	5	and	and	CCONJ
admet-1513	169	6	s9	s9	VERB
admet-1513	169	7	fraction	fraction	NOUN
admet-1513	169	8	metabolic	metabolic	NOUN
admet-1513	169	9	stability	stability	NOUN
admet-1513	169	10	assays	assay	NOUN
admet-1513	169	11	by	by	ADP
admet-1513	169	12	liver	liver	NOUN
admet-1513	169	13	microsomes	microsome	NOUN
admet-1513	169	14	,	,	PUNCT
admet-1513	169	15	cytosolic	cytosolic	NOUN
admet-1513	169	16	and/or	and/or	CCONJ
admet-1513	169	17	s9	s9	NOUN
admet-1513	169	18	fractions	fraction	NOUN
admet-1513	169	19	are	be	AUX
admet-1513	169	20	the	the	DET
admet-1513	169	21	most	most	ADV
admet-1513	169	22	commonly	commonly	ADV
admet-1513	169	23	used	use	VERB
admet-1513	169	24	model	model	NOUN
admet-1513	169	25	for	for	ADP
admet-1513	169	26	studying	study	VERB
admet-1513	169	27	drug	drug	NOUN
admet-1513	169	28	clearance	clearance	NOUN
admet-1513	169	29	in	in	ADP
admet-1513	169	30	vitro	vitro	X
admet-1513	169	31	apart	apart	ADV
admet-1513	169	32	from	from	ADP
admet-1513	169	33	primary	primary	ADJ
admet-1513	169	34	hepatocytes	hepatocyte	NOUN
admet-1513	169	35	.	.	PUNCT
admet-1513	170	1	microsomes	microsome	NOUN
admet-1513	170	2	are	be	AUX
admet-1513	170	3	the	the	DET
admet-1513	170	4	major	major	ADJ
admet-1513	170	5	repository	repository	NOUN
admet-1513	170	6	of	of	ADP
admet-1513	170	7	phase	phase	NOUN
admet-1513	170	8	-	-	PUNCT
admet-1513	170	9	i	i	NOUN
admet-1513	170	10	metabolizing	metabolize	VERB
admet-1513	170	11	enzymes	enzyme	NOUN
admet-1513	170	12	,	,	PUNCT
admet-1513	170	13	i.e.	i.e.	X
admet-1513	170	14	,	,	PUNCT
admet-1513	170	15	oxidation	oxidation	NOUN
admet-1513	170	16	(	(	PUNCT
admet-1513	170	17	majorly	majorly	ADV
admet-1513	170	18	by	by	ADP
admet-1513	170	19	cyps	cyps	PROPN
admet-1513	170	20	)	)	PUNCT
admet-1513	170	21	,	,	PUNCT
admet-1513	170	22	reduction	reduction	NOUN
admet-1513	170	23	and	and	CCONJ
admet-1513	170	24	hydrolysis	hydrolysis	NOUN
admet-1513	170	25	,	,	PUNCT
admet-1513	170	26	which	which	PRON
admet-1513	170	27	helps	help	VERB
admet-1513	170	28	convert	convert	VERB
admet-1513	170	29	the	the	DET
admet-1513	170	30	lipophilic	lipophilic	ADJ
admet-1513	170	31	drugs	drug	NOUN
admet-1513	170	32	into	into	ADP
admet-1513	170	33	polar	polar	ADJ
admet-1513	170	34	compounds	compound	NOUN
admet-1513	170	35	by	by	ADP
admet-1513	170	36	adding	add	VERB
admet-1513	170	37	–	–	PUNCT
admet-1513	170	38	oh	oh	INTJ
admet-1513	170	39	or	or	CCONJ
admet-1513	170	40	nh2	nh2	NOUN
admet-1513	170	41	functional	functional	ADJ
admet-1513	170	42	groups	group	NOUN
admet-1513	170	43	.	.	PUNCT
admet-1513	171	1	the	the	DET
admet-1513	171	2	cytosolic	cytosolic	ADJ
admet-1513	171	3	fraction	fraction	NOUN
admet-1513	171	4	consists	consist	VERB
admet-1513	171	5	of	of	ADP
admet-1513	171	6	various	various	ADJ
admet-1513	171	7	water	water	NOUN
admet-1513	171	8	-	-	PUNCT
admet-1513	171	9	soluble	soluble	ADJ
admet-1513	171	10	metabolizing	metabolize	VERB
admet-1513	171	11	enzymes	enzyme	NOUN
admet-1513	171	12	and	and	CCONJ
admet-1513	171	13	involved	involve	VERB
admet-1513	171	14	phase	phase	NOUN
admet-1513	171	15	-	-	PUNCT
admet-1513	171	16	ii	ii	NOUN
admet-1513	171	17	metabolism	metabolism	NOUN
admet-1513	171	18	,	,	PUNCT
admet-1513	171	19	i.e.	i.e.	X
admet-1513	171	20	,	,	PUNCT
admet-1513	171	21	glucuronidation	glucuronidation	NOUN
admet-1513	171	22	,	,	PUNCT
admet-1513	171	23	methylation	methylation	NOUN
admet-1513	171	24	,	,	PUNCT
admet-1513	171	25	acetylation	acetylation	NOUN
admet-1513	171	26	,	,	PUNCT
admet-1513	171	27	sulfation	sulfation	NOUN
admet-1513	171	28	and	and	CCONJ
admet-1513	171	29	conjugation	conjugation	NOUN
admet-1513	171	30	,	,	PUNCT
admet-1513	171	31	which	which	PRON
admet-1513	171	32	helps	help	VERB
admet-1513	171	33	in	in	ADP
admet-1513	171	34	transforming	transform	VERB
admet-1513	171	35	the	the	DET
admet-1513	171	36	drug	drug	NOUN
admet-1513	171	37	molecules	molecule	NOUN
admet-1513	171	38	or	or	CCONJ
admet-1513	171	39	the	the	DET
admet-1513	171	40	metabolites	metabolite	NOUN
admet-1513	171	41	from	from	ADP
admet-1513	171	42	phase	phase	NOUN
admet-1513	171	43	-	-	PUNCT
admet-1513	171	44	i	i	NOUN
admet-1513	171	45	to	to	ADP
admet-1513	171	46	more	more	ADV
admet-1513	171	47	polar	polar	ADJ
admet-1513	171	48	compounds	compound	NOUN
admet-1513	171	49	ultimately	ultimately	ADV
admet-1513	171	50	making	make	VERB
admet-1513	171	51	them	they	PRON
admet-1513	171	52	easy	easy	ADJ
admet-1513	171	53	excretion	excretion	NOUN
admet-1513	171	54	from	from	ADP
admet-1513	171	55	the	the	DET
admet-1513	171	56	body	body	NOUN
admet-1513	171	57	.	.	PUNCT
admet-1513	172	1	s9	s9	NOUN
admet-1513	172	2	fraction	fraction	NOUN
admet-1513	172	3	consists	consist	VERB
admet-1513	172	4	of	of	ADP
admet-1513	172	5	both	both	CCONJ
admet-1513	172	6	cytoplasmic	cytoplasmic	ADJ
admet-1513	172	7	and	and	CCONJ
admet-1513	172	8	microsomal	microsomal	ADJ
admet-1513	172	9	fractions	fraction	NOUN
admet-1513	172	10	,	,	PUNCT
admet-1513	172	11	thus	thus	ADV
admet-1513	172	12	constituting	constitute	VERB
admet-1513	172	13	both	both	DET
admet-1513	172	14	phase	phase	NOUN
admet-1513	172	15	-	-	PUNCT
admet-1513	172	16	i	i	NOUN
admet-1513	172	17	and	and	CCONJ
admet-1513	172	18	phase	phase	NOUN
admet-1513	172	19	-	-	PUNCT
admet-1513	172	20	ii	ii	NOUN
admet-1513	172	21	metabolism	metabolism	NOUN
admet-1513	172	22	.	.	PUNCT
admet-1513	173	1	but	but	CCONJ
admet-1513	173	2	the	the	DET
admet-1513	173	3	major	major	ADJ
admet-1513	173	4	drawback	drawback	NOUN
admet-1513	173	5	of	of	ADP
admet-1513	173	6	this	this	DET
admet-1513	173	7	model	model	NOUN
admet-1513	173	8	is	be	AUX
admet-1513	173	9	the	the	DET
admet-1513	173	10	lack	lack	NOUN
admet-1513	173	11	of	of	ADP
admet-1513	173	12	a	a	DET
admet-1513	173	13	cell	cell	NOUN
admet-1513	173	14	membrane	membrane	NOUN
admet-1513	173	15	barrier	barrier	NOUN
admet-1513	173	16	that	that	PRON
admet-1513	173	17	confronts	confront	VERB
admet-1513	173	18	the	the	DET
admet-1513	173	19	drug	drug	NOUN
admet-1513	173	20	to	to	PART
admet-1513	173	21	reach	reach	VERB
admet-1513	173	22	the	the	DET
admet-1513	173	23	cytoplasmic	cytoplasmic	ADJ
admet-1513	173	24	compartment	compartment	NOUN
admet-1513	173	25	[	[	X
admet-1513	173	26	63	63	NUM
admet-1513	173	27	]	]	PUNCT
admet-1513	173	28	.	.	PUNCT
admet-1513	174	1	in	in	ADP
admet-1513	174	2	contrast	contrast	NOUN
admet-1513	174	3	,	,	PUNCT
admet-1513	174	4	the	the	DET
admet-1513	174	5	major	major	ADJ
admet-1513	174	6	advantage	advantage	NOUN
admet-1513	174	7	of	of	ADP
admet-1513	174	8	this	this	DET
admet-1513	174	9	model	model	NOUN
admet-1513	174	10	is	be	AUX
admet-1513	174	11	direct	direct	ADJ
admet-1513	174	12	interactions	interaction	NOUN
admet-1513	174	13	of	of	ADP
admet-1513	174	14	metabolizing	metabolize	VERB
admet-1513	174	15	enzymes	enzyme	NOUN
admet-1513	174	16	with	with	ADP
admet-1513	174	17	the	the	DET
admet-1513	174	18	drug	drug	NOUN
admet-1513	174	19	make	make	VERB
admet-1513	174	20	it	it	PRON
admet-1513	174	21	suitable	suitable	ADJ
admet-1513	174	22	as	as	ADP
admet-1513	174	23	a	a	DET
admet-1513	174	24	paradigm	paradigm	NOUN
admet-1513	174	25	for	for	ADP
admet-1513	174	26	screening	screen	VERB
admet-1513	174	27	studies	study	NOUN
admet-1513	174	28	[	[	X
admet-1513	174	29	73	73	NUM
admet-1513	174	30	]	]	PUNCT
admet-1513	174	31	.	.	PUNCT
admet-1513	175	1	cell	cell	NOUN
admet-1513	175	2	lines	line	NOUN
admet-1513	175	3	derived	derive	VERB
admet-1513	175	4	from	from	ADP
admet-1513	175	5	hepatoma	hepatoma	NOUN
admet-1513	175	6	the	the	DET
admet-1513	175	7	most	most	ADV
admet-1513	175	8	frequently	frequently	ADV
admet-1513	175	9	used	use	VERB
admet-1513	175	10	cell	cell	NOUN
admet-1513	175	11	lines	line	NOUN
admet-1513	175	12	include	include	VERB
admet-1513	175	13	hepg2	hepg2	NOUN
admet-1513	175	14	or	or	CCONJ
admet-1513	175	15	hep3b	hep3b	PROPN
admet-1513	175	16	,	,	PUNCT
admet-1513	175	17	huh7	huh7	NOUN
admet-1513	175	18	,	,	PUNCT
admet-1513	175	19	and	and	CCONJ
admet-1513	175	20	heprg	heprg	ADV
admet-1513	175	21	.	.	PUNCT
admet-1513	176	1	the	the	DET
admet-1513	176	2	major	major	ADJ
admet-1513	176	3	advantages	advantage	NOUN
admet-1513	176	4	of	of	ADP
admet-1513	176	5	these	these	DET
admet-1513	176	6	cell	cell	NOUN
admet-1513	176	7	lines	line	NOUN
admet-1513	176	8	include	include	VERB
admet-1513	176	9	accessibility	accessibility	NOUN
admet-1513	176	10	,	,	PUNCT
admet-1513	176	11	ease	ease	NOUN
admet-1513	176	12	of	of	ADP
admet-1513	176	13	use	use	NOUN
admet-1513	176	14	,	,	PUNCT
admet-1513	176	15	stable	stable	ADJ
admet-1513	176	16	phenotype	phenotype	NOUN
admet-1513	176	17	and	and	CCONJ
admet-1513	176	18	limitless	limitless	ADJ
admet-1513	176	19	potential	potential	NOUN
admet-1513	176	20	for	for	ADP
admet-1513	176	21	replication	replication	NOUN
admet-1513	176	22	.	.	PUNCT
admet-1513	177	1	hepg2	hepg2	PROPN
admet-1513	177	2	(	(	PUNCT
admet-1513	177	3	liver	liver	VERB
admet-1513	177	4	hepatocellular	hepatocellular	ADJ
admet-1513	177	5	carcinoma	carcinoma	NOUN
admet-1513	177	6	)	)	PUNCT
admet-1513	177	7	hepg2	hepg2	NOUN
admet-1513	177	8	is	be	AUX
admet-1513	177	9	the	the	DET
admet-1513	177	10	most	most	ADV
admet-1513	177	11	commonly	commonly	ADV
admet-1513	177	12	used	use	VERB
admet-1513	177	13	cell	cell	NOUN
admet-1513	177	14	line	line	NOUN
admet-1513	177	15	for	for	ADP
admet-1513	177	16	studying	study	VERB
admet-1513	177	17	drug	drug	NOUN
admet-1513	177	18	metabolism	metabolism	NOUN
admet-1513	177	19	and	and	CCONJ
admet-1513	177	20	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	177	21	studies	study	NOUN
admet-1513	177	22	.	.	PUNCT
admet-1513	178	1	these	these	DET
admet-1513	178	2	cell	cell	NOUN
admet-1513	178	3	lines	line	NOUN
admet-1513	178	4	are	be	AUX
admet-1513	178	5	non	non	ADJ
admet-1513	178	6	-	-	ADJ
admet-1513	178	7	tumorogenic	tumorogenic	ADJ
admet-1513	178	8	,	,	PUNCT
admet-1513	178	9	having	have	VERB
admet-1513	178	10	high	high	ADJ
admet-1513	178	11	proliferation	proliferation	NOUN
admet-1513	178	12	rates	rate	NOUN
admet-1513	178	13	and	and	CCONJ
admet-1513	178	14	epithelial	epithelial	ADJ
admet-1513	178	15	morphology	morphology	NOUN
admet-1513	178	16	having	have	VERB
admet-1513	178	17	diverse	diverse	ADJ
admet-1513	178	18	hepatic	hepatic	ADJ
admet-1513	178	19	functions	function	NOUN
admet-1513	178	20	.	.	PUNCT
admet-1513	179	1	these	these	DET
admet-1513	179	2	cell	cell	NOUN
admet-1513	179	3	lines	line	NOUN
admet-1513	179	4	are	be	AUX
admet-1513	179	5	functionally	functionally	ADV
admet-1513	179	6	characterized	characterize	VERB
admet-1513	179	7	by	by	ADP
admet-1513	179	8	the	the	DET
admet-1513	179	9	synthesis	synthesis	NOUN
admet-1513	179	10	and	and	CCONJ
admet-1513	179	11	secretion	secretion	NOUN
admet-1513	179	12	of	of	ADP
admet-1513	179	13	plasma	plasma	NOUN
admet-1513	179	14	proteins	protein	NOUN
admet-1513	179	15	,	,	PUNCT
admet-1513	179	16	cholesterol	cholesterol	NOUN
admet-1513	179	17	and	and	CCONJ
admet-1513	179	18	triglyceride	triglyceride	ADJ
admet-1513	179	19	metabolism	metabolism	NOUN
admet-1513	179	20	,	,	PUNCT
admet-1513	179	21	lipoprotein	lipoprotein	ADJ
admet-1513	179	22	metabolism	metabolism	NOUN
admet-1513	179	23	and	and	CCONJ
admet-1513	179	24	transport	transport	NOUN
admet-1513	179	25	,	,	PUNCT
admet-1513	179	26	bile	bile	NOUN
admet-1513	179	27	acid	acid	NOUN
admet-1513	179	28	synthesis	synthesis	NOUN
admet-1513	179	29	,	,	PUNCT
admet-1513	179	30	glycogen	glycogen	NOUN
admet-1513	179	31	synthesis	synthesis	NOUN
admet-1513	179	32	,	,	PUNCT
admet-1513	179	33	and	and	CCONJ
admet-1513	179	34	insulin	insulin	NOUN
admet-1513	179	35	signalling	signal	VERB
admet-1513	179	36	[	[	X
admet-1513	179	37	74	74	NUM
admet-1513	179	38	]	]	PUNCT
admet-1513	179	39	.	.	PUNCT
admet-1513	180	1	but	but	CCONJ
admet-1513	180	2	the	the	DET
admet-1513	180	3	major	major	ADJ
admet-1513	180	4	drawback	drawback	NOUN
admet-1513	180	5	of	of	ADP
admet-1513	180	6	hepg2	hepg2	NOUN
admet-1513	180	7	is	be	AUX
admet-1513	180	8	the	the	DET
admet-1513	180	9	limited	limited	ADJ
admet-1513	180	10	expression	expression	NOUN
admet-1513	180	11	of	of	ADP
admet-1513	180	12	cyp	cyp	ADJ
admet-1513	180	13	enzymes	enzyme	NOUN
admet-1513	180	14	.	.	PUNCT
admet-1513	181	1	this	this	DET
admet-1513	181	2	very	very	ADV
admet-1513	181	3	low	low	ADJ
admet-1513	181	4	expression	expression	NOUN
admet-1513	181	5	is	be	AUX
admet-1513	181	6	mainly	mainly	ADV
admet-1513	181	7	due	due	ADP
admet-1513	181	8	to	to	ADP
admet-1513	181	9	the	the	DET
admet-1513	181	10	down	down	ADJ
admet-1513	181	11	-	-	PUNCT
admet-1513	181	12	regulation	regulation	NOUN
admet-1513	181	13	of	of	ADP
admet-1513	181	14	transcription	transcription	NOUN
admet-1513	181	15	factor	factor	NOUN
admet-1513	181	16	car	car	NOUN
admet-1513	181	17	and	and	CCONJ
admet-1513	181	18	pxr	pxr	NOUN
admet-1513	182	1	[	[	X
admet-1513	182	2	75	75	NUM
admet-1513	182	3	]	]	PUNCT
admet-1513	182	4	.	.	PUNCT
admet-1513	183	1	even	even	ADV
admet-1513	183	2	the	the	DET
admet-1513	183	3	expression	expression	NOUN
admet-1513	183	4	of	of	ADP
admet-1513	183	5	phase	phase	NOUN
admet-1513	183	6	-	-	PUNCT
admet-1513	183	7	ii	ii	NOUN
admet-1513	183	8	metabolizing	metabolize	VERB
admet-1513	183	9	enzymes	enzyme	NOUN
admet-1513	183	10	such	such	ADJ
admet-1513	183	11	as	as	ADP
admet-1513	183	12	uridine	uridine	NOUN
admet-1513	183	13	diphosphate	diphosphate	NOUN
admet-1513	183	14	glucuronosyltransferase	glucuronosyltransferase	NOUN
admet-1513	183	15	,	,	PUNCT
admet-1513	183	16	glutathione	glutathione	NOUN
admet-1513	183	17	s	s	NOUN
admet-1513	183	18	-	-	NOUN
admet-1513	183	19	transferase	transferase	NOUN
admet-1513	183	20	(	(	PUNCT
admet-1513	183	21	gst	gst	NOUN
admet-1513	183	22	)	)	PUNCT
admet-1513	183	23	,	,	PUNCT
admet-1513	183	24	sulfotransferase	sulfotransferase	VERB
admet-1513	183	25	,	,	PUNCT
admet-1513	183	26	or	or	CCONJ
admet-1513	183	27	n	n	CCONJ
admet-1513	183	28	-	-	PUNCT
admet-1513	183	29	acetyltransferase	acetyltransferase	NOUN
admet-1513	183	30	(	(	PUNCT
admet-1513	183	31	nat	nat	NOUN
admet-1513	183	32	)	)	PUNCT
admet-1513	183	33	are	be	AUX
admet-1513	183	34	also	also	ADV
admet-1513	183	35	less	less	ADJ
admet-1513	183	36	when	when	SCONJ
admet-1513	183	37	compared	compare	VERB
admet-1513	183	38	to	to	ADP
admet-1513	183	39	primary	primary	ADJ
admet-1513	183	40	hepatocytes	hepatocyte	NOUN
admet-1513	183	41	,	,	PUNCT
admet-1513	183	42	but	but	CCONJ
admet-1513	183	43	their	their	PRON
admet-1513	183	44	expression	expression	NOUN
admet-1513	183	45	is	be	AUX
admet-1513	183	46	more	more	ADJ
admet-1513	183	47	than	than	ADP
admet-1513	183	48	cyps	cyps	PROPN
admet-1513	183	49	.	.	PUNCT
admet-1513	184	1	and	and	CCONJ
admet-1513	184	2	finally	finally	ADV
admet-1513	184	3	,	,	PUNCT
admet-1513	184	4	the	the	DET
admet-1513	184	5	expression	expression	NOUN
admet-1513	184	6	of	of	ADP
admet-1513	184	7	transporter	transporter	NOUN
admet-1513	184	8	proteins	protein	NOUN
admet-1513	184	9	such	such	ADJ
admet-1513	184	10	as	as	ADP
admet-1513	184	11	ntcp	ntcp	NOUN
admet-1513	184	12	,	,	PUNCT
admet-1513	184	13	bile	bile	NOUN
admet-1513	184	14	salt	salt	NOUN
admet-1513	184	15	export	export	NOUN
admet-1513	184	16	pump	pump	NOUN
admet-1513	184	17	(	(	PUNCT
admet-1513	184	18	bsep	bsep	NOUN
admet-1513	184	19	)	)	PUNCT
admet-1513	184	20	,	,	PUNCT
admet-1513	184	21	and	and	CCONJ
admet-1513	184	22	oatp	oatp	ADJ
admet-1513	184	23	are	be	AUX
admet-1513	184	24	also	also	ADV
admet-1513	184	25	very	very	ADV
admet-1513	184	26	limited	limited	ADJ
admet-1513	184	27	in	in	ADP
admet-1513	184	28	hepg2	hepg2	NOUN
admet-1513	184	29	than	than	ADP
admet-1513	184	30	primary	primary	ADJ
admet-1513	184	31	hepatocytes	hepatocyte	NOUN
admet-1513	185	1	[	[	X
admet-1513	185	2	74	74	NUM
admet-1513	185	3	]	]	PUNCT
admet-1513	185	4	.	.	PUNCT
admet-1513	186	1	huh-7	huh-7	PUNCT
admet-1513	186	2	huh-7	huh-7	X
admet-1513	186	3	cells	cell	NOUN
admet-1513	186	4	,	,	PUNCT
admet-1513	186	5	along	along	ADP
admet-1513	186	6	with	with	ADP
admet-1513	186	7	their	their	PRON
admet-1513	186	8	derivatives	derivative	NOUN
admet-1513	186	9	huh-7.5	huh-7.5	NOUN
admet-1513	186	10	and	and	CCONJ
admet-1513	186	11	huh-7.5.1	huh-7.5.1	PROPN
admet-1513	186	12	,	,	PUNCT
admet-1513	186	13	have	have	AUX
admet-1513	186	14	been	be	AUX
admet-1513	186	15	vastly	vastly	ADV
admet-1513	186	16	used	use	VERB
admet-1513	186	17	as	as	ADP
admet-1513	186	18	a	a	DET
admet-1513	186	19	convenient	convenient	ADJ
admet-1513	186	20	substitute	substitute	NOUN
admet-1513	186	21	for	for	ADP
admet-1513	186	22	primary	primary	ADJ
admet-1513	186	23	hepatocytes	hepatocyte	NOUN
admet-1513	187	1	[	[	X
admet-1513	187	2	76	76	NUM
admet-1513	187	3	]	]	PUNCT
admet-1513	187	4	.	.	PUNCT
admet-1513	188	1	these	these	DET
admet-1513	188	2	cell	cell	NOUN
admet-1513	188	3	lines	line	NOUN
admet-1513	188	4	are	be	AUX
admet-1513	188	5	also	also	ADV
admet-1513	188	6	well	well	ADV
admet-1513	188	7	-	-	PUNCT
admet-1513	188	8	differentiated	differentiate	VERB
admet-1513	188	9	hepatoma	hepatoma	ADJ
admet-1513	188	10	cell	cell	NOUN
admet-1513	188	11	lines	line	NOUN
admet-1513	188	12	which	which	PRON
admet-1513	188	13	are	be	AUX
admet-1513	188	14	functionally	functionally	ADV
admet-1513	188	15	characterized	characterize	VERB
admet-1513	188	16	by	by	ADP
admet-1513	188	17	the	the	DET
admet-1513	188	18	secretion	secretion	NOUN
admet-1513	188	19	of	of	ADP
admet-1513	188	20	albumin	albumin	ADJ
admet-1513	188	21	proteins	protein	NOUN
admet-1513	188	22	and	and	CCONJ
admet-1513	188	23	enzymes	enzyme	NOUN
admet-1513	188	24	for	for	ADP
admet-1513	188	25	carbohydrate	carbohydrate	ADJ
admet-1513	188	26	metabolism	metabolism	NOUN
admet-1513	188	27	[	[	X
admet-1513	188	28	51	51	NUM
admet-1513	188	29	]	]	PUNCT
admet-1513	188	30	.	.	PUNCT
admet-1513	189	1	similar	similar	ADJ
admet-1513	189	2	to	to	ADP
admet-1513	189	3	hepg2	hepg2	PROPN
admet-1513	189	4	,	,	PUNCT
admet-1513	189	5	the	the	DET
admet-1513	189	6	use	use	NOUN
admet-1513	189	7	of	of	ADP
admet-1513	189	8	these	these	DET
admet-1513	189	9	cell	cell	NOUN
admet-1513	189	10	lines	line	NOUN
admet-1513	189	11	was	be	AUX
admet-1513	189	12	restricted	restrict	VERB
admet-1513	189	13	because	because	SCONJ
admet-1513	189	14	of	of	ADP
admet-1513	189	15	the	the	DET
admet-1513	189	16	limited	limited	ADJ
admet-1513	189	17	expression	expression	NOUN
admet-1513	189	18	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	189	19	venkatesh	venkatesh	PROPN
admet-1513	189	20	chunduri	chunduri	PROPN
admet-1513	189	21	and	and	CCONJ
admet-1513	189	22	srinivas	srinivas	PROPN
admet-1513	189	23	maddi	maddi	PROPN
admet-1513	189	24	admet	admet	PROPN
admet-1513	189	25	&	&	CCONJ
admet-1513	189	26	dmpk	dmpk	PROPN
admet-1513	189	27	11(1	11(1	NUM
admet-1513	189	28	)	)	PUNCT
admet-1513	189	29	(	(	PUNCT
admet-1513	189	30	2023	2023	NUM
admet-1513	189	31	)	)	PUNCT
admet-1513	189	32	1	1	NUM
admet-1513	189	33	-	-	SYM
admet-1513	189	34	32	32	NUM
admet-1513	189	35	8	8	NUM
admet-1513	189	36	of	of	ADP
admet-1513	189	37	drug	drug	NOUN
admet-1513	189	38	-	-	PUNCT
admet-1513	189	39	metabolizing	metabolize	VERB
admet-1513	189	40	enzymes	enzyme	NOUN
admet-1513	189	41	.	.	PUNCT
admet-1513	190	1	but	but	CCONJ
admet-1513	190	2	some	some	DET
admet-1513	190	3	recent	recent	ADJ
admet-1513	190	4	reports	report	NOUN
admet-1513	190	5	revealed	reveal	VERB
admet-1513	190	6	that	that	SCONJ
admet-1513	190	7	upon	upon	SCONJ
admet-1513	190	8	dmso	dmso	ADJ
admet-1513	190	9	treatment	treatment	NOUN
admet-1513	190	10	,	,	PUNCT
admet-1513	190	11	these	these	DET
admet-1513	190	12	cells	cell	NOUN
admet-1513	190	13	have	have	VERB
admet-1513	190	14	well	well	ADV
admet-1513	190	15	-	-	PUNCT
admet-1513	190	16	differentiated	differentiate	VERB
admet-1513	190	17	morphology	morphology	NOUN
admet-1513	190	18	as	as	ADP
admet-1513	190	19	that	that	PRON
admet-1513	190	20	of	of	ADP
admet-1513	190	21	hepatocytes	hepatocyte	NOUN
admet-1513	190	22	,	,	PUNCT
admet-1513	190	23	significant	significant	ADJ
admet-1513	190	24	overexpression	overexpression	NOUN
admet-1513	190	25	of	of	ADP
admet-1513	190	26	drug	drug	NOUN
admet-1513	190	27	-	-	PUNCT
admet-1513	190	28	metabolizing	metabolize	VERB
admet-1513	190	29	enzymes	enzyme	NOUN
admet-1513	190	30	and	and	CCONJ
admet-1513	190	31	up	up	ADP
admet-1513	190	32	-	-	PUNCT
admet-1513	190	33	regulation	regulation	NOUN
admet-1513	190	34	of	of	ADP
admet-1513	190	35	liver	liver	NOUN
admet-1513	190	36	-	-	PUNCT
admet-1513	190	37	specific	specific	ADJ
admet-1513	190	38	proteins	protein	NOUN
admet-1513	190	39	like	like	ADP
admet-1513	190	40	albumin	albumin	NOUN
admet-1513	190	41	,	,	PUNCT
admet-1513	190	42	transthyretin	transthyretin	PROPN
admet-1513	190	43	,	,	PUNCT
admet-1513	190	44	hnf4a	hnf4a	PROPN
admet-1513	190	45	,	,	PUNCT
admet-1513	190	46	and	and	CCONJ
admet-1513	190	47	a1	a1	NOUN
admet-1513	190	48	-	-	PUNCT
admet-1513	190	49	antitrypsin	antitrypsin	NOUN
admet-1513	190	50	[	[	X
admet-1513	190	51	77	77	NUM
admet-1513	190	52	]	]	PUNCT
admet-1513	190	53	.	.	PUNCT
admet-1513	191	1	although	although	SCONJ
admet-1513	191	2	there	there	PRON
admet-1513	191	3	is	be	VERB
admet-1513	191	4	an	an	DET
admet-1513	191	5	increased	increase	VERB
admet-1513	191	6	expression	expression	NOUN
admet-1513	191	7	,	,	PUNCT
admet-1513	191	8	the	the	DET
admet-1513	191	9	expression	expression	NOUN
admet-1513	191	10	of	of	ADP
admet-1513	191	11	prominent	prominent	ADJ
admet-1513	191	12	metabolism	metabolism	NOUN
admet-1513	191	13	enzymes	enzyme	NOUN
admet-1513	191	14	like	like	ADP
admet-1513	191	15	cyp	cyp	ADJ
admet-1513	191	16	and	and	CCONJ
admet-1513	191	17	ugt	ugt	NOUN
admet-1513	191	18	is	be	AUX
admet-1513	191	19	10	10	NUM
admet-1513	191	20	-	-	ADJ
admet-1513	191	21	fold	fold	VERB
admet-1513	191	22	lower	low	ADJ
admet-1513	191	23	than	than	ADP
admet-1513	191	24	that	that	PRON
admet-1513	191	25	of	of	ADP
admet-1513	191	26	primary	primary	ADJ
admet-1513	191	27	hepatocytes	hepatocyte	NOUN
admet-1513	191	28	[	[	X
admet-1513	191	29	77	77	NUM
admet-1513	191	30	]	]	PUNCT
admet-1513	191	31	.	.	PUNCT
admet-1513	192	1	although	although	SCONJ
admet-1513	192	2	the	the	DET
admet-1513	192	3	metabolizing	metabolize	VERB
admet-1513	192	4	enzyme	enzyme	NOUN
admet-1513	192	5	activity	activity	NOUN
admet-1513	192	6	is	be	AUX
admet-1513	192	7	less	less	ADJ
admet-1513	192	8	in	in	ADP
admet-1513	192	9	huh7	huh7	NOUN
admet-1513	192	10	cells	cell	NOUN
admet-1513	192	11	,	,	PUNCT
admet-1513	192	12	constant	constant	ADJ
admet-1513	192	13	phase	phase	NOUN
admet-1513	192	14	-	-	PUNCT
admet-1513	192	15	i	i	NOUN
admet-1513	192	16	and	and	CCONJ
admet-1513	192	17	phase	phase	NOUN
admet-1513	192	18	-	-	PUNCT
admet-1513	192	19	ii	ii	NOUN
admet-1513	192	20	enzyme	enzyme	NOUN
admet-1513	192	21	activities	activity	NOUN
admet-1513	192	22	were	be	AUX
admet-1513	192	23	observed	observe	VERB
admet-1513	192	24	over	over	ADP
admet-1513	192	25	the	the	DET
admet-1513	192	26	passages	passage	NOUN
admet-1513	192	27	,	,	PUNCT
admet-1513	192	28	making	make	VERB
admet-1513	192	29	them	they	PRON
admet-1513	192	30	the	the	DET
admet-1513	192	31	better	well	ADJ
admet-1513	192	32	alternative	alternative	NOUN
admet-1513	192	33	for	for	ADP
admet-1513	192	34	hepg2	hepg2	NOUN
admet-1513	192	35	cells	cell	NOUN
admet-1513	192	36	[	[	X
admet-1513	192	37	78	78	NUM
admet-1513	192	38	]	]	PUNCT
admet-1513	192	39	.	.	PUNCT
admet-1513	193	1	heprg	heprg	PROPN
admet-1513	193	2	these	these	PRON
admet-1513	193	3	are	be	AUX
admet-1513	193	4	established	establish	VERB
admet-1513	193	5	cell	cell	NOUN
admet-1513	193	6	lines	line	NOUN
admet-1513	193	7	from	from	ADP
admet-1513	193	8	chronic	chronic	ADJ
admet-1513	193	9	hepatitis	hepatitis	PROPN
admet-1513	193	10	c	c	PROPN
admet-1513	193	11	liver	liver	NOUN
admet-1513	193	12	tumours	tumour	NOUN
admet-1513	193	13	.	.	PUNCT
admet-1513	194	1	studies	study	NOUN
admet-1513	194	2	have	have	AUX
admet-1513	194	3	shown	show	VERB
admet-1513	194	4	its	its	PRON
admet-1513	194	5	bipotent	bipotent	NOUN
admet-1513	194	6	capacity	capacity	NOUN
admet-1513	194	7	,	,	PUNCT
admet-1513	194	8	which	which	PRON
admet-1513	194	9	can	can	AUX
admet-1513	194	10	differentiate	differentiate	VERB
admet-1513	194	11	into	into	ADP
admet-1513	194	12	two	two	NUM
admet-1513	194	13	phenotypes	phenotype	NOUN
admet-1513	194	14	,	,	PUNCT
admet-1513	194	15	i.e.	i.e.	X
admet-1513	194	16	,	,	PUNCT
admet-1513	194	17	hepatic	hepatic	ADJ
admet-1513	194	18	type	type	NOUN
admet-1513	194	19	and	and	CCONJ
admet-1513	194	20	biliary	biliary	NOUN
admet-1513	194	21	type	type	NOUN
admet-1513	194	22	[	[	X
admet-1513	194	23	79	79	NUM
admet-1513	194	24	]	]	PUNCT
admet-1513	194	25	.	.	PUNCT
admet-1513	195	1	several	several	ADJ
admet-1513	195	2	studies	study	NOUN
admet-1513	195	3	have	have	AUX
admet-1513	195	4	reported	report	VERB
admet-1513	195	5	that	that	SCONJ
admet-1513	195	6	the	the	DET
admet-1513	195	7	expression	expression	NOUN
admet-1513	195	8	pattern	pattern	NOUN
admet-1513	195	9	of	of	ADP
admet-1513	195	10	phase	phase	NOUN
admet-1513	195	11	-	-	PUNCT
admet-1513	195	12	i	i	NOUN
admet-1513	195	13	and	and	CCONJ
admet-1513	195	14	phase	phase	NOUN
admet-1513	195	15	-	-	PUNCT
admet-1513	195	16	ii	ii	NOUN
admet-1513	195	17	drug	drug	NOUN
admet-1513	195	18	metabolizing	metabolize	VERB
admet-1513	195	19	enzymes	enzyme	NOUN
admet-1513	195	20	is	be	AUX
admet-1513	195	21	similar	similar	ADJ
admet-1513	195	22	to	to	ADP
admet-1513	195	23	that	that	PRON
admet-1513	195	24	of	of	ADP
admet-1513	195	25	primary	primary	ADJ
admet-1513	195	26	hepatocytes	hepatocyte	NOUN
admet-1513	195	27	under	under	ADP
admet-1513	195	28	the	the	DET
admet-1513	195	29	presence	presence	NOUN
admet-1513	195	30	of	of	ADP
admet-1513	195	31	minimal	minimal	ADJ
admet-1513	195	32	dmso	dmso	ADJ
admet-1513	195	33	concentrations	concentration	NOUN
admet-1513	195	34	.	.	PUNCT
admet-1513	196	1	but	but	CCONJ
admet-1513	196	2	their	their	PRON
admet-1513	196	3	activity	activity	NOUN
admet-1513	196	4	decreases	decrease	VERB
admet-1513	196	5	once	once	SCONJ
admet-1513	196	6	the	the	DET
admet-1513	196	7	dmso	dmso	NOUN
admet-1513	196	8	is	be	AUX
admet-1513	196	9	removed	remove	VERB
admet-1513	196	10	from	from	ADP
admet-1513	196	11	the	the	DET
admet-1513	196	12	medium	medium	NOUN
admet-1513	196	13	[	[	X
admet-1513	196	14	80	80	NUM
admet-1513	196	15	]	]	PUNCT
admet-1513	196	16	.	.	PUNCT
admet-1513	197	1	the	the	DET
admet-1513	197	2	major	major	ADJ
admet-1513	197	3	advantages	advantage	NOUN
admet-1513	197	4	of	of	ADP
admet-1513	197	5	using	use	VERB
admet-1513	197	6	this	this	DET
admet-1513	197	7	heprg	heprg	PROPN
admet-1513	197	8	are	be	AUX
admet-1513	197	9	less	less	ADV
admet-1513	197	10	functional	functional	ADJ
admet-1513	197	11	variation	variation	NOUN
admet-1513	197	12	over	over	ADP
admet-1513	197	13	the	the	DET
admet-1513	197	14	passages	passage	NOUN
admet-1513	197	15	,	,	PUNCT
admet-1513	197	16	morphological	morphological	ADJ
admet-1513	197	17	and	and	CCONJ
admet-1513	197	18	functional	functional	ADJ
admet-1513	197	19	similarity	similarity	NOUN
admet-1513	197	20	to	to	ADP
admet-1513	197	21	that	that	PRON
admet-1513	197	22	of	of	ADP
admet-1513	197	23	primary	primary	ADJ
admet-1513	197	24	hepatocytes	hepatocyte	NOUN
admet-1513	197	25	under	under	ADP
admet-1513	197	26	differentiated	differentiated	ADJ
admet-1513	197	27	conditions	condition	NOUN
admet-1513	197	28	,	,	PUNCT
admet-1513	197	29	and	and	CCONJ
admet-1513	197	30	no	no	DET
admet-1513	197	31	inter	inter	ADJ
admet-1513	197	32	donor	donor	NOUN
admet-1513	197	33	variation	variation	NOUN
admet-1513	197	34	[	[	X
admet-1513	197	35	51	51	NUM
admet-1513	197	36	]	]	PUNCT
admet-1513	197	37	.	.	PUNCT
admet-1513	198	1	moreover	moreover	ADV
admet-1513	198	2	,	,	PUNCT
admet-1513	198	3	these	these	DET
admet-1513	198	4	cell	cell	NOUN
admet-1513	198	5	lines	line	NOUN
admet-1513	198	6	are	be	AUX
admet-1513	198	7	susceptible	susceptible	ADJ
admet-1513	198	8	to	to	ADP
admet-1513	198	9	common	common	ADJ
admet-1513	198	10	cyp	cyp	ADJ
admet-1513	198	11	inhibitors	inhibitor	NOUN
admet-1513	198	12	.	.	PUNCT
admet-1513	199	1	studies	study	NOUN
admet-1513	199	2	reported	report	VERB
admet-1513	199	3	that	that	SCONJ
admet-1513	199	4	upon	upon	SCONJ
admet-1513	199	5	treatment	treatment	NOUN
admet-1513	199	6	with	with	ADP
admet-1513	199	7	β	β	NOUN
admet-1513	199	8	-	-	ADJ
admet-1513	199	9	naphthoflavone	naphthoflavone	ADJ
admet-1513	199	10	,	,	PUNCT
admet-1513	199	11	phenobarbital	phenobarbital	ADJ
admet-1513	199	12	and	and	CCONJ
admet-1513	199	13	rifampicin	rifampicin	VERB
admet-1513	199	14	induced	induce	VERB
admet-1513	199	15	the	the	DET
admet-1513	199	16	expression	expression	NOUN
admet-1513	199	17	of	of	ADP
admet-1513	199	18	different	different	ADJ
admet-1513	199	19	cyp	cyp	ADJ
admet-1513	199	20	enzymes	enzyme	NOUN
admet-1513	199	21	to	to	ADP
admet-1513	199	22	multiple	multiple	ADJ
admet-1513	199	23	folds	fold	NOUN
admet-1513	200	1	[	[	X
admet-1513	200	2	81	81	NUM
admet-1513	200	3	]	]	PUNCT
admet-1513	200	4	.	.	PUNCT
admet-1513	201	1	reports	report	NOUN
admet-1513	201	2	also	also	ADV
admet-1513	201	3	showed	show	VERB
admet-1513	201	4	that	that	SCONJ
admet-1513	201	5	heprg	heprg	PROPN
admet-1513	201	6	is	be	AUX
admet-1513	201	7	a	a	DET
admet-1513	201	8	better	well	ADJ
admet-1513	201	9	model	model	NOUN
admet-1513	201	10	for	for	ADP
admet-1513	201	11	studying	study	VERB
admet-1513	201	12	dili	dili	PROPN
admet-1513	201	13	.	.	PUNCT
admet-1513	202	1	the	the	DET
admet-1513	202	2	response	response	NOUN
admet-1513	202	3	of	of	ADP
admet-1513	202	4	heprg	heprg	ADJ
admet-1513	202	5	towards	towards	ADP
admet-1513	202	6	acetaminophen	acetaminophen	NOUN
admet-1513	202	7	,	,	PUNCT
admet-1513	202	8	i.e.	i.e.	X
admet-1513	202	9	,	,	PUNCT
admet-1513	202	10	over	over	ADP
admet-1513	202	11	-	-	PUNCT
admet-1513	202	12	expression	expression	NOUN
admet-1513	202	13	of	of	ADP
admet-1513	202	14	genes	gene	NOUN
admet-1513	202	15	related	relate	VERB
admet-1513	202	16	to	to	ADP
admet-1513	202	17	liver	liver	NOUN
admet-1513	202	18	damage	damage	NOUN
admet-1513	202	19	,	,	PUNCT
admet-1513	202	20	is	be	AUX
admet-1513	202	21	similar	similar	ADJ
admet-1513	202	22	to	to	ADP
admet-1513	202	23	that	that	PRON
admet-1513	202	24	of	of	ADP
admet-1513	202	25	primary	primary	ADJ
admet-1513	202	26	hepatocytes	hepatocyte	NOUN
admet-1513	202	27	and	and	CCONJ
admet-1513	202	28	much	much	ADV
admet-1513	202	29	higher	high	ADJ
admet-1513	202	30	when	when	SCONJ
admet-1513	202	31	compared	compare	VERB
admet-1513	202	32	to	to	ADP
admet-1513	202	33	hepg2	hepg2	NOUN
admet-1513	202	34	cells	cell	NOUN
admet-1513	202	35	[	[	X
admet-1513	202	36	80	80	NUM
admet-1513	202	37	]	]	PUNCT
admet-1513	202	38	.	.	PUNCT
admet-1513	203	1	this	this	DET
admet-1513	203	2	inductive	inductive	ADJ
admet-1513	203	3	capacity	capacity	NOUN
admet-1513	203	4	has	have	AUX
admet-1513	203	5	made	make	VERB
admet-1513	203	6	heprg	heprg	ADP
admet-1513	203	7	an	an	DET
admet-1513	203	8	excellent	excellent	ADJ
admet-1513	203	9	alternative	alternative	ADJ
admet-1513	203	10	model	model	NOUN
admet-1513	203	11	for	for	ADP
admet-1513	203	12	primary	primary	ADJ
admet-1513	203	13	hepatocytes	hepatocyte	NOUN
admet-1513	203	14	.	.	PUNCT
admet-1513	204	1	moreover	moreover	ADV
admet-1513	204	2	,	,	PUNCT
admet-1513	204	3	the	the	DET
admet-1513	204	4	susceptibility	susceptibility	NOUN
admet-1513	204	5	of	of	ADP
admet-1513	204	6	heprg	heprg	PROPN
admet-1513	204	7	to	to	ADP
admet-1513	204	8	various	various	ADJ
admet-1513	204	9	bioactivated	bioactivated	ADJ
admet-1513	204	10	toxins	toxin	NOUN
admet-1513	204	11	such	such	ADJ
admet-1513	204	12	as	as	ADP
admet-1513	204	13	alphatoxin	alphatoxin	PROPN
admet-1513	204	14	b1	b1	PROPN
admet-1513	204	15	makes	make	VERB
admet-1513	204	16	them	they	PRON
admet-1513	204	17	a	a	DET
admet-1513	204	18	better	well	ADJ
admet-1513	204	19	model	model	NOUN
admet-1513	204	20	for	for	ADP
admet-1513	204	21	studying	study	VERB
admet-1513	204	22	cytotoxicity	cytotoxicity	NOUN
admet-1513	204	23	studies	study	NOUN
admet-1513	204	24	over	over	ADP
admet-1513	204	25	hepg2	hepg2	NOUN
admet-1513	204	26	cell	cell	NOUN
admet-1513	204	27	lines	line	NOUN
admet-1513	204	28	[	[	X
admet-1513	204	29	51	51	NUM
admet-1513	204	30	]	]	PUNCT
admet-1513	204	31	.	.	PUNCT
admet-1513	205	1	excretion	excretion	NOUN
admet-1513	205	2	excretion	excretion	NOUN
admet-1513	205	3	is	be	AUX
admet-1513	205	4	another	another	DET
admet-1513	205	5	important	important	ADJ
admet-1513	205	6	parameter	parameter	NOUN
admet-1513	205	7	in	in	ADP
admet-1513	205	8	pk	pk	NOUN
admet-1513	205	9	,	,	PUNCT
admet-1513	205	10	as	as	SCONJ
admet-1513	205	11	any	any	DET
admet-1513	205	12	drug	drug	NOUN
admet-1513	205	13	absorbed	absorb	VERB
admet-1513	205	14	should	should	AUX
admet-1513	205	15	be	be	AUX
admet-1513	205	16	eliminated	eliminate	VERB
admet-1513	205	17	from	from	ADP
admet-1513	205	18	the	the	DET
admet-1513	205	19	body	body	NOUN
admet-1513	205	20	within	within	ADP
admet-1513	205	21	a	a	DET
admet-1513	205	22	specified	specify	VERB
admet-1513	205	23	time	time	NOUN
admet-1513	205	24	.	.	PUNCT
admet-1513	206	1	the	the	DET
admet-1513	206	2	liver	liver	NOUN
admet-1513	206	3	is	be	AUX
admet-1513	206	4	responsible	responsible	ADJ
admet-1513	206	5	for	for	ADP
admet-1513	206	6	the	the	DET
admet-1513	206	7	biotransformation	biotransformation	NOUN
admet-1513	206	8	of	of	ADP
admet-1513	206	9	absorbed	absorb	VERB
admet-1513	206	10	drugs	drug	NOUN
admet-1513	206	11	or	or	CCONJ
admet-1513	206	12	exogenous	exogenous	ADJ
admet-1513	206	13	compounds	compound	NOUN
admet-1513	206	14	and	and	CCONJ
admet-1513	206	15	helps	help	VERB
admet-1513	206	16	in	in	ADP
admet-1513	206	17	the	the	DET
admet-1513	206	18	storage	storage	NOUN
admet-1513	206	19	and	and	CCONJ
admet-1513	206	20	excretion	excretion	NOUN
admet-1513	206	21	of	of	ADP
admet-1513	206	22	these	these	DET
admet-1513	206	23	compounds	compound	NOUN
admet-1513	206	24	and	and	CCONJ
admet-1513	206	25	their	their	PRON
admet-1513	206	26	metabolites	metabolite	NOUN
admet-1513	206	27	through	through	ADP
admet-1513	206	28	bile	bile	NOUN
admet-1513	206	29	.	.	PUNCT
admet-1513	207	1	in	in	ADP
admet-1513	207	2	addition	addition	NOUN
admet-1513	207	3	to	to	ADP
admet-1513	207	4	the	the	DET
admet-1513	207	5	liver	liver	NOUN
admet-1513	207	6	,	,	PUNCT
admet-1513	207	7	drug	drug	NOUN
admet-1513	207	8	clearance	clearance	NOUN
admet-1513	207	9	is	be	AUX
admet-1513	207	10	also	also	ADV
admet-1513	207	11	contributed	contribute	VERB
admet-1513	207	12	by	by	ADP
admet-1513	207	13	various	various	ADJ
admet-1513	207	14	transporters	transporter	NOUN
admet-1513	207	15	and	and	CCONJ
admet-1513	207	16	metabolizing	metabolize	VERB
admet-1513	207	17	enzymes	enzyme	NOUN
admet-1513	207	18	in	in	ADP
admet-1513	207	19	the	the	DET
admet-1513	207	20	git	git	NOUN
admet-1513	207	21	and	and	CCONJ
admet-1513	207	22	kidneys	kidney	NOUN
admet-1513	207	23	[	[	X
admet-1513	207	24	82,83	82,83	NUM
admet-1513	207	25	]	]	PUNCT
admet-1513	207	26	.	.	PUNCT
admet-1513	208	1	drug	drug	NOUN
admet-1513	208	2	transporters	transporter	NOUN
admet-1513	208	3	are	be	AUX
admet-1513	208	4	considered	consider	VERB
admet-1513	208	5	important	important	ADJ
admet-1513	208	6	determinants	determinant	NOUN
admet-1513	208	7	of	of	ADP
admet-1513	208	8	drug	drug	NOUN
admet-1513	208	9	accumulation	accumulation	NOUN
admet-1513	208	10	within	within	ADP
admet-1513	208	11	the	the	DET
admet-1513	208	12	cells	cell	NOUN
admet-1513	208	13	and	and	CCONJ
admet-1513	208	14	are	be	AUX
admet-1513	208	15	often	often	ADV
admet-1513	208	16	correlated	correlate	VERB
admet-1513	208	17	with	with	ADP
admet-1513	208	18	efficacy	efficacy	NOUN
admet-1513	208	19	,	,	PUNCT
admet-1513	208	20	drug	drug	NOUN
admet-1513	208	21	toxicity	toxicity	NOUN
admet-1513	208	22	,	,	PUNCT
admet-1513	208	23	and	and	CCONJ
admet-1513	208	24	drug	drug	NOUN
admet-1513	208	25	-	-	PUNCT
admet-1513	208	26	drug	drug	NOUN
admet-1513	208	27	interactions	interaction	NOUN
admet-1513	208	28	.	.	PUNCT
admet-1513	209	1	in	in	ADP
admet-1513	209	2	addition	addition	NOUN
admet-1513	209	3	to	to	ADP
admet-1513	209	4	providing	provide	VERB
admet-1513	209	5	resistance	resistance	NOUN
admet-1513	209	6	to	to	ADP
admet-1513	209	7	a	a	DET
admet-1513	209	8	wide	wide	ADJ
admet-1513	209	9	range	range	NOUN
admet-1513	209	10	of	of	ADP
admet-1513	209	11	drugs	drug	NOUN
admet-1513	209	12	,	,	PUNCT
admet-1513	209	13	transporters	transporter	NOUN
admet-1513	209	14	also	also	ADV
admet-1513	209	15	play	play	VERB
admet-1513	209	16	a	a	DET
admet-1513	209	17	major	major	ADJ
admet-1513	209	18	role	role	NOUN
admet-1513	209	19	in	in	ADP
admet-1513	209	20	the	the	DET
admet-1513	209	21	adme	adme	NOUN
admet-1513	209	22	process	process	NOUN
admet-1513	209	23	[	[	X
admet-1513	209	24	84	84	NUM
admet-1513	209	25	]	]	PUNCT
admet-1513	209	26	.	.	PUNCT
admet-1513	210	1	these	these	DET
admet-1513	210	2	transporters	transporter	NOUN
admet-1513	210	3	are	be	AUX
admet-1513	210	4	majorly	majorly	ADV
admet-1513	210	5	classified	classify	VERB
admet-1513	210	6	into	into	ADP
admet-1513	210	7	influx	influx	NOUN
admet-1513	210	8	and	and	CCONJ
admet-1513	210	9	efflux	efflux	VERB
admet-1513	210	10	transporters	transporter	NOUN
admet-1513	210	11	.	.	PUNCT
admet-1513	211	1	influx	influx	VERB
admet-1513	211	2	transporters	transporter	NOUN
admet-1513	211	3	majorly	majorly	ADV
admet-1513	211	4	belong	belong	VERB
admet-1513	211	5	to	to	ADP
admet-1513	211	6	the	the	DET
admet-1513	211	7	solute	solute	NOUN
admet-1513	211	8	carrier	carrier	NOUN
admet-1513	211	9	(	(	PUNCT
admet-1513	211	10	slc	slc	PROPN
admet-1513	211	11	)	)	PUNCT
admet-1513	211	12	family	family	NOUN
admet-1513	211	13	and	and	CCONJ
admet-1513	211	14	are	be	AUX
admet-1513	211	15	expressed	express	VERB
admet-1513	211	16	in	in	ADP
admet-1513	211	17	the	the	DET
admet-1513	211	18	plasma	plasma	NOUN
admet-1513	211	19	membrane	membrane	NOUN
admet-1513	211	20	of	of	ADP
admet-1513	211	21	all	all	DET
admet-1513	211	22	organs	organ	NOUN
admet-1513	211	23	.	.	PUNCT
admet-1513	212	1	the	the	DET
admet-1513	212	2	slc	slc	PROPN
admet-1513	212	3	family	family	NOUN
admet-1513	212	4	mainly	mainly	ADV
admet-1513	212	5	includes	include	VERB
admet-1513	212	6	organic	organic	ADJ
admet-1513	212	7	anion	anion	NOUN
admet-1513	212	8	-	-	PUNCT
admet-1513	212	9	transporting	transport	VERB
admet-1513	212	10	polypeptides	polypeptide	NOUN
admet-1513	212	11	(	(	PUNCT
admet-1513	212	12	oatps	oatps	NOUN
admet-1513	212	13	/	/	SYM
admet-1513	212	14	slcos	slcos	NOUN
admet-1513	212	15	)	)	PUNCT
admet-1513	212	16	,	,	PUNCT
admet-1513	212	17	organic	organic	ADJ
admet-1513	212	18	anion	anion	NOUN
admet-1513	212	19	transporters	transporter	NOUN
admet-1513	212	20	(	(	PUNCT
admet-1513	212	21	oats	oats	NOUN
admet-1513	212	22	/	/	SYM
admet-1513	212	23	slc22as	slc22as	PROPN
admet-1513	212	24	)	)	PUNCT
admet-1513	212	25	,	,	PUNCT
admet-1513	212	26	organic	organic	ADJ
admet-1513	212	27	cation	cation	NOUN
admet-1513	212	28	transporter	transporter	NOUN
admet-1513	212	29	(	(	PUNCT
admet-1513	212	30	octs	oct	NOUN
admet-1513	212	31	/	/	SYM
admet-1513	212	32	slc22as	slc22as	PROPN
admet-1513	212	33	)	)	PUNCT
admet-1513	212	34	,	,	PUNCT
admet-1513	212	35	organic	organic	ADJ
admet-1513	212	36	cation	cation	NOUN
admet-1513	212	37	and	and	CCONJ
admet-1513	212	38	carnitine	carnitine	NOUN
admet-1513	212	39	transporters	transporter	NOUN
admet-1513	212	40	(	(	PUNCT
admet-1513	212	41	octns	octns	PROPN
admet-1513	212	42	/	/	SYM
admet-1513	212	43	slc22as	slc22as	PROPN
admet-1513	212	44	)	)	PUNCT
admet-1513	212	45	,	,	PUNCT
admet-1513	212	46	peptide	peptide	NOUN
admet-1513	212	47	transporters	transporter	NOUN
admet-1513	212	48	(	(	PUNCT
admet-1513	212	49	pepts	pept	NOUN
admet-1513	212	50	/	/	SYM
admet-1513	212	51	slc15as	slc15as	NOUN
admet-1513	212	52	)	)	PUNCT
admet-1513	212	53	.	.	PUNCT
admet-1513	213	1	these	these	DET
admet-1513	213	2	transporters	transporter	NOUN
admet-1513	213	3	mediate	mediate	VERB
admet-1513	213	4	the	the	DET
admet-1513	213	5	entry	entry	NOUN
admet-1513	213	6	of	of	ADP
admet-1513	213	7	drugs	drug	NOUN
admet-1513	213	8	from	from	ADP
admet-1513	213	9	blood	blood	NOUN
admet-1513	213	10	vessels	vessel	NOUN
admet-1513	213	11	to	to	ADP
admet-1513	213	12	tissues	tissue	NOUN
admet-1513	213	13	and	and	CCONJ
admet-1513	213	14	organs	organ	NOUN
admet-1513	213	15	either	either	CCONJ
admet-1513	213	16	by	by	ADP
admet-1513	213	17	passive	passive	ADJ
admet-1513	213	18	diffusion	diffusion	NOUN
admet-1513	213	19	or	or	CCONJ
admet-1513	213	20	co	co	NOUN
admet-1513	213	21	-	-	NOUN
admet-1513	213	22	transport	transport	NOUN
admet-1513	213	23	or	or	CCONJ
admet-1513	213	24	active	active	ADJ
admet-1513	213	25	transport	transport	NOUN
admet-1513	213	26	with	with	ADP
admet-1513	213	27	the	the	DET
admet-1513	213	28	help	help	NOUN
admet-1513	213	29	of	of	ADP
admet-1513	213	30	atp	atp	NOUN
admet-1513	213	31	hydrolysis	hydrolysis	NOUN
admet-1513	213	32	.	.	PUNCT
admet-1513	214	1	these	these	DET
admet-1513	214	2	slc	slc	PROPN
admet-1513	214	3	transporters	transporter	NOUN
admet-1513	214	4	are	be	AUX
admet-1513	214	5	generally	generally	ADV
admet-1513	214	6	expressed	express	VERB
admet-1513	214	7	on	on	ADP
admet-1513	214	8	diverse	diverse	ADJ
admet-1513	214	9	tissue	tissue	NOUN
admet-1513	214	10	membranes	membrane	NOUN
admet-1513	214	11	like	like	ADP
admet-1513	214	12	the	the	DET
admet-1513	214	13	intestine	intestine	NOUN
admet-1513	214	14	,	,	PUNCT
admet-1513	214	15	kidney	kidney	NOUN
admet-1513	214	16	,	,	PUNCT
admet-1513	214	17	brain	brain	NOUN
admet-1513	214	18	and	and	CCONJ
admet-1513	214	19	liver	liver	NOUN
admet-1513	214	20	to	to	PART
admet-1513	214	21	show	show	VERB
admet-1513	214	22	their	their	PRON
admet-1513	214	23	therapeutic	therapeutic	ADJ
admet-1513	214	24	effect	effect	NOUN
admet-1513	214	25	,	,	PUNCT
admet-1513	214	26	toxicity	toxicity	NOUN
admet-1513	214	27	,	,	PUNCT
admet-1513	214	28	or	or	CCONJ
admet-1513	214	29	metabolism	metabolism	NOUN
admet-1513	214	30	in	in	ADP
admet-1513	214	31	the	the	DET
admet-1513	214	32	case	case	NOUN
admet-1513	214	33	of	of	ADP
admet-1513	214	34	hepatocytes	hepatocytes	PROPN
admet-1513	214	35	.	.	PUNCT
admet-1513	215	1	efflux	efflux	VERB
admet-1513	215	2	transporters	transporter	NOUN
admet-1513	215	3	export	export	VERB
admet-1513	215	4	the	the	DET
admet-1513	215	5	drug	drug	NOUN
admet-1513	215	6	out	out	ADP
admet-1513	215	7	of	of	ADP
admet-1513	215	8	cells	cell	NOUN
admet-1513	215	9	into	into	ADP
admet-1513	215	10	blood	blood	NOUN
admet-1513	215	11	vessels	vessel	NOUN
admet-1513	215	12	or	or	CCONJ
admet-1513	215	13	excretory	excretory	NOUN
admet-1513	215	14	vessels	vessel	NOUN
admet-1513	215	15	by	by	ADP
admet-1513	215	16	utilizing	utilize	VERB
admet-1513	215	17	an	an	DET
admet-1513	215	18	atp	atp	NOUN
admet-1513	215	19	energy	energy	NOUN
admet-1513	215	20	source	source	NOUN
admet-1513	215	21	.	.	PUNCT
admet-1513	216	1	most	most	ADJ
admet-1513	216	2	of	of	ADP
admet-1513	216	3	the	the	DET
admet-1513	216	4	efflux	efflux	ADJ
admet-1513	216	5	transporters	transporter	NOUN
admet-1513	216	6	belong	belong	VERB
admet-1513	216	7	to	to	ADP
admet-1513	216	8	atp	atp	PROPN
admet-1513	216	9	binding	bind	VERB
admet-1513	216	10	cassette	cassette	NOUN
admet-1513	216	11	(	(	PUNCT
admet-1513	216	12	abc	abc	PROPN
admet-1513	216	13	)	)	PUNCT
admet-1513	216	14	transporters	transporter	NOUN
admet-1513	216	15	family	family	NOUN
admet-1513	216	16	[	[	X
admet-1513	216	17	85	85	NUM
admet-1513	216	18	]	]	PUNCT
admet-1513	216	19	except	except	SCONJ
admet-1513	216	20	multidrug	multidrug	NOUN
admet-1513	216	21	and	and	CCONJ
admet-1513	216	22	toxin	toxin	NOUN
admet-1513	216	23	extrusions	extrusion	NOUN
admet-1513	216	24	(	(	PUNCT
admet-1513	216	25	mates	mate	NOUN
admet-1513	216	26	/	/	SYM
admet-1513	216	27	slc47as	slc47as	PROPN
admet-1513	216	28	)	)	PUNCT
admet-1513	216	29	,	,	PUNCT
admet-1513	216	30	which	which	PRON
admet-1513	216	31	belong	belong	VERB
admet-1513	216	32	to	to	ADP
admet-1513	216	33	the	the	DET
admet-1513	216	34	slc	slc	PROPN
admet-1513	216	35	family	family	NOUN
admet-1513	216	36	.	.	PUNCT
admet-1513	217	1	among	among	ADP
admet-1513	217	2	the	the	DET
admet-1513	217	3	abc	abc	PROPN
admet-1513	217	4	transporters	transporter	NOUN
admet-1513	217	5	,	,	PUNCT
admet-1513	217	6	multidrug	multidrug	NOUN
admet-1513	217	7	resistance	resistance	NOUN
admet-1513	217	8	(	(	PUNCT
admet-1513	217	9	mdr	mdr	PROPN
admet-1513	217	10	)	)	PUNCT
admet-1513	217	11	,	,	PUNCT
admet-1513	217	12	p	p	NOUN
admet-1513	217	13	-	-	PUNCT
admet-1513	217	14	gp	gp	NOUN
admet-1513	217	15	and	and	CCONJ
admet-1513	217	16	bcrp	bcrp	ADV
admet-1513	217	17	are	be	AUX
admet-1513	217	18	majorly	majorly	ADV
admet-1513	217	19	involved	involve	VERB
admet-1513	217	20	in	in	ADP
admet-1513	217	21	the	the	DET
admet-1513	217	22	excretion	excretion	NOUN
admet-1513	217	23	of	of	ADP
admet-1513	217	24	drugs	drug	NOUN
admet-1513	217	25	and	and	CCONJ
admet-1513	217	26	admet	admet	PROPN
admet-1513	217	27	&	&	CCONJ
admet-1513	217	28	dmpk	dmpk	PROPN
admet-1513	217	29	11(1	11(1	NUM
admet-1513	217	30	)	)	PUNCT
admet-1513	217	31	(	(	PUNCT
admet-1513	217	32	2023	2023	NUM
admet-1513	217	33	)	)	PUNCT
admet-1513	217	34	1	1	NUM
admet-1513	217	35	-	-	SYM
admet-1513	217	36	32	32	NUM
admet-1513	217	37	2d	2d	NOUN
admet-1513	217	38	and	and	CCONJ
admet-1513	217	39	3d	3d	NOUN
admet-1513	217	40	adme	adme	PROPN
admet-1513	217	41	-	-	PUNCT
admet-1513	217	42	tox	tox	NOUN
admet-1513	217	43	cell	cell	NOUN
admet-1513	217	44	culture	culture	NOUN
admet-1513	217	45	screening	screen	VERB
admet-1513	217	46	:	:	PUNCT
admet-1513	217	47	a	a	DET
admet-1513	217	48	review	review	NOUN
admet-1513	217	49	doi	doi	NOUN
admet-1513	217	50	:	:	PUNCT
admet-1513	217	51	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	217	52	9	9	NUM
admet-1513	217	53	their	their	PRON
admet-1513	217	54	metabolites	metabolite	NOUN
admet-1513	217	55	from	from	ADP
admet-1513	217	56	hepatocytes	hepatocyte	NOUN
admet-1513	217	57	to	to	ADP
admet-1513	217	58	bile	bile	NOUN
admet-1513	217	59	and	and	CCONJ
admet-1513	217	60	renal	renal	ADJ
admet-1513	217	61	epithelial	epithelial	ADJ
admet-1513	217	62	cells	cell	NOUN
admet-1513	217	63	to	to	ADP
admet-1513	217	64	lumen	luman	NOUN
admet-1513	217	65	.	.	PUNCT
admet-1513	218	1	in	in	ADP
admet-1513	218	2	the	the	DET
admet-1513	218	3	liver	liver	NOUN
admet-1513	218	4	,	,	PUNCT
admet-1513	218	5	these	these	DET
admet-1513	218	6	efflux	efflux	NOUN
admet-1513	218	7	transporters	transporter	NOUN
admet-1513	218	8	are	be	AUX
admet-1513	218	9	expressed	express	VERB
admet-1513	218	10	on	on	ADP
admet-1513	218	11	basolateral	basolateral	ADJ
admet-1513	218	12	and	and	CCONJ
admet-1513	218	13	canalicular	canalicular	ADJ
admet-1513	218	14	membranes	membrane	NOUN
admet-1513	218	15	of	of	ADP
admet-1513	218	16	hepatocytes	hepatocyte	NOUN
admet-1513	218	17	and	and	CCONJ
admet-1513	218	18	play	play	VERB
admet-1513	218	19	a	a	DET
admet-1513	218	20	major	major	ADJ
admet-1513	218	21	role	role	NOUN
admet-1513	218	22	in	in	ADP
admet-1513	218	23	mediating	mediate	VERB
admet-1513	218	24	the	the	DET
admet-1513	218	25	drugs	drug	NOUN
admet-1513	218	26	and	and	CCONJ
admet-1513	218	27	metabolites	metabolite	NOUN
admet-1513	218	28	from	from	ADP
admet-1513	218	29	hepatic	hepatic	ADJ
admet-1513	218	30	cytosol	cytosol	NOUN
admet-1513	218	31	to	to	ADP
admet-1513	218	32	blood	blood	NOUN
admet-1513	218	33	and	and	CCONJ
admet-1513	218	34	bile	bile	NOUN
admet-1513	218	35	[	[	X
admet-1513	218	36	86	86	NUM
admet-1513	218	37	]	]	PUNCT
admet-1513	218	38	.	.	PUNCT
admet-1513	219	1	similarly	similarly	ADV
admet-1513	219	2	,	,	PUNCT
admet-1513	219	3	in	in	ADP
admet-1513	219	4	the	the	DET
admet-1513	219	5	kidney	kidney	NOUN
admet-1513	219	6	,	,	PUNCT
admet-1513	219	7	these	these	DET
admet-1513	219	8	efflux	efflux	NOUN
admet-1513	219	9	transporters	transporter	NOUN
admet-1513	219	10	are	be	AUX
admet-1513	219	11	expressed	express	VERB
admet-1513	219	12	on	on	ADP
admet-1513	219	13	the	the	DET
admet-1513	219	14	apical	apical	ADJ
admet-1513	219	15	membrane	membrane	NOUN
admet-1513	219	16	of	of	ADP
admet-1513	219	17	the	the	DET
admet-1513	219	18	renal	renal	ADJ
admet-1513	219	19	epithelial	epithelial	ADJ
admet-1513	219	20	cells	cell	NOUN
admet-1513	219	21	and	and	CCONJ
admet-1513	219	22	play	play	VERB
admet-1513	219	23	a	a	DET
admet-1513	219	24	major	major	ADJ
admet-1513	219	25	role	role	NOUN
admet-1513	219	26	in	in	ADP
admet-1513	219	27	eliminating	eliminate	VERB
admet-1513	219	28	the	the	DET
admet-1513	219	29	drugs	drug	NOUN
admet-1513	219	30	from	from	ADP
admet-1513	219	31	epithelial	epithelial	ADJ
admet-1513	219	32	cells	cell	NOUN
admet-1513	219	33	to	to	ADP
admet-1513	219	34	the	the	DET
admet-1513	219	35	lumen	luman	NOUN
admet-1513	219	36	of	of	ADP
admet-1513	219	37	the	the	DET
admet-1513	219	38	urine	urine	NOUN
admet-1513	219	39	.	.	PUNCT
admet-1513	220	1	most	most	ADJ
admet-1513	220	2	renal	renal	ADJ
admet-1513	220	3	transporters	transporter	NOUN
admet-1513	220	4	include	include	VERB
admet-1513	220	5	oat1	oat1	PROPN
admet-1513	220	6	,	,	PUNCT
admet-1513	220	7	oat3	oat3	PROPN
admet-1513	220	8	,	,	PUNCT
admet-1513	220	9	oct2	oct2	NOUN
admet-1513	220	10	,	,	PUNCT
admet-1513	220	11	mate	mate	NOUN
admet-1513	220	12	,	,	PUNCT
admet-1513	220	13	p	p	NOUN
admet-1513	220	14	-	-	PUNCT
admet-1513	220	15	gp	gp	NOUN
admet-1513	220	16	and	and	CCONJ
admet-1513	220	17	bcrp	bcrp	ADV
admet-1513	220	18	.	.	PUNCT
admet-1513	221	1	these	these	DET
admet-1513	221	2	transporters	transporter	NOUN
admet-1513	221	3	actively	actively	ADV
admet-1513	221	4	help	help	VERB
admet-1513	221	5	in	in	ADP
admet-1513	221	6	the	the	DET
admet-1513	221	7	excretion	excretion	NOUN
admet-1513	221	8	of	of	ADP
admet-1513	221	9	xenobiotics	xenobiotics	PROPN
admet-1513	221	10	from	from	ADP
admet-1513	221	11	blood	blood	NOUN
admet-1513	221	12	to	to	ADP
admet-1513	221	13	urine	urine	NOUN
admet-1513	221	14	.	.	PUNCT
admet-1513	222	1	researchers	researcher	NOUN
admet-1513	222	2	have	have	AUX
admet-1513	222	3	developed	develop	VERB
admet-1513	222	4	various	various	ADJ
admet-1513	222	5	in	in	ADP
admet-1513	222	6	vitro	vitro	X
admet-1513	222	7	models	model	NOUN
admet-1513	222	8	like	like	ADP
admet-1513	222	9	transporter	transporter	NOUN
admet-1513	222	10	assays	assay	NOUN
admet-1513	222	11	and	and	CCONJ
admet-1513	222	12	cellbased	cellbase	VERB
admet-1513	222	13	assays	assay	NOUN
admet-1513	222	14	for	for	ADP
admet-1513	222	15	determining	determine	VERB
admet-1513	222	16	the	the	DET
admet-1513	222	17	drug	drug	NOUN
admet-1513	222	18	elimination	elimination	NOUN
admet-1513	222	19	process	process	NOUN
admet-1513	222	20	.	.	PUNCT
admet-1513	223	1	the	the	DET
admet-1513	223	2	in	in	ADP
admet-1513	223	3	vitro	vitro	X
admet-1513	223	4	models	model	NOUN
admet-1513	223	5	for	for	ADP
admet-1513	223	6	studying	study	VERB
admet-1513	223	7	the	the	DET
admet-1513	223	8	process	process	NOUN
admet-1513	223	9	of	of	ADP
admet-1513	223	10	transport	transport	NOUN
admet-1513	223	11	and	and	CCONJ
admet-1513	223	12	excretion	excretion	NOUN
admet-1513	223	13	include	include	VERB
admet-1513	223	14	membrane	membrane	NOUN
admet-1513	223	15	-	-	PUNCT
admet-1513	223	16	based	base	VERB
admet-1513	223	17	assays	assay	NOUN
admet-1513	223	18	and	and	CCONJ
admet-1513	223	19	cell	cell	NOUN
admet-1513	223	20	-	-	PUNCT
admet-1513	223	21	based	base	VERB
admet-1513	223	22	assays	assay	NOUN
admet-1513	223	23	.	.	PUNCT
admet-1513	224	1	membrane	membrane	NOUN
admet-1513	224	2	-	-	PUNCT
admet-1513	224	3	based	base	VERB
admet-1513	224	4	assays	assay	NOUN
admet-1513	224	5	are	be	AUX
admet-1513	224	6	generally	generally	ADV
admet-1513	224	7	used	use	VERB
admet-1513	224	8	to	to	PART
admet-1513	224	9	identify	identify	VERB
admet-1513	224	10	the	the	DET
admet-1513	224	11	substrates	substrate	NOUN
admet-1513	224	12	and	and	CCONJ
admet-1513	224	13	inhibitors	inhibitor	NOUN
admet-1513	224	14	of	of	ADP
admet-1513	224	15	particular	particular	ADJ
admet-1513	224	16	transporters	transporter	NOUN
admet-1513	224	17	.	.	PUNCT
admet-1513	225	1	these	these	DET
admet-1513	225	2	assays	assay	NOUN
admet-1513	225	3	can	can	AUX
admet-1513	225	4	be	be	AUX
admet-1513	225	5	performed	perform	VERB
admet-1513	225	6	by	by	ADP
admet-1513	225	7	simple	simple	ADJ
admet-1513	225	8	atpase	atpase	PROPN
admet-1513	225	9	assays	assay	NOUN
admet-1513	225	10	and	and	CCONJ
admet-1513	225	11	membrane	membrane	NOUN
admet-1513	225	12	vesicular	vesicular	ADJ
admet-1513	225	13	transporter	transporter	NOUN
admet-1513	225	14	assays	assay	NOUN
admet-1513	225	15	.	.	PUNCT
admet-1513	226	1	in	in	ADP
admet-1513	226	2	the	the	DET
admet-1513	226	3	case	case	NOUN
admet-1513	226	4	of	of	ADP
admet-1513	226	5	atpase	atpase	PROPN
admet-1513	226	6	assays	assay	NOUN
admet-1513	226	7	,	,	PUNCT
admet-1513	226	8	the	the	DET
admet-1513	226	9	substrates	substrate	NOUN
admet-1513	226	10	or	or	CCONJ
admet-1513	226	11	inhibitors	inhibitor	NOUN
admet-1513	226	12	are	be	AUX
admet-1513	226	13	incubated	incubate	VERB
admet-1513	226	14	with	with	ADP
admet-1513	226	15	cells	cell	NOUN
admet-1513	226	16	expressing	express	VERB
admet-1513	226	17	abc	abc	PROPN
admet-1513	226	18	transporters	transporter	NOUN
admet-1513	226	19	and	and	CCONJ
admet-1513	226	20	the	the	DET
admet-1513	226	21	generated	generate	VERB
admet-1513	226	22	inorganic	inorganic	ADJ
admet-1513	226	23	phosphate	phosphate	NOUN
admet-1513	226	24	is	be	AUX
admet-1513	226	25	estimated	estimate	VERB
admet-1513	226	26	calorimetrically	calorimetrically	ADV
admet-1513	226	27	[	[	X
admet-1513	226	28	87	87	NUM
admet-1513	226	29	]	]	PUNCT
admet-1513	226	30	.	.	PUNCT
admet-1513	227	1	whereas	whereas	SCONJ
admet-1513	227	2	membrane	membrane	ADJ
admet-1513	227	3	vesicular	vesicular	ADJ
admet-1513	227	4	transport	transport	NOUN
admet-1513	227	5	assay	assay	VERB
admet-1513	227	6	generally	generally	ADV
admet-1513	227	7	uses	use	VERB
admet-1513	227	8	inside	inside	ADV
admet-1513	227	9	-	-	PUNCT
admet-1513	227	10	out	out	ADP
admet-1513	227	11	oriented	orient	VERB
admet-1513	227	12	membranes	membrane	NOUN
admet-1513	227	13	prepared	prepare	VERB
admet-1513	227	14	from	from	ADP
admet-1513	227	15	different	different	ADJ
admet-1513	227	16	cell	cell	NOUN
admet-1513	227	17	lines	line	NOUN
admet-1513	227	18	expressing	express	VERB
admet-1513	227	19	abc	abc	PROPN
admet-1513	227	20	(	(	PUNCT
admet-1513	227	21	e.g.	e.g.	ADV
admet-1513	227	22	,	,	PUNCT
admet-1513	227	23	sf9	sf9	VERB
admet-1513	227	24	insect	insect	NOUN
admet-1513	227	25	cells	cell	NOUN
admet-1513	227	26	,	,	PUNCT
admet-1513	227	27	hek293	hek293	PROPN
admet-1513	227	28	and	and	CCONJ
admet-1513	227	29	mdck	mdck	PROPN
admet-1513	227	30	cells	cell	NOUN
admet-1513	227	31	)	)	PUNCT
admet-1513	228	1	[	[	X
admet-1513	228	2	88	88	NUM
admet-1513	228	3	]	]	PUNCT
admet-1513	228	4	.	.	PUNCT
admet-1513	229	1	compared	compare	VERB
admet-1513	229	2	to	to	ADP
admet-1513	229	3	atpase	atpase	PROPN
admet-1513	229	4	assays	assay	NOUN
admet-1513	229	5	,	,	PUNCT
admet-1513	229	6	vesicular	vesicular	ADJ
admet-1513	229	7	assays	assay	NOUN
admet-1513	229	8	have	have	VERB
admet-1513	229	9	the	the	DET
admet-1513	229	10	upper	upper	ADJ
admet-1513	229	11	hand	hand	NOUN
admet-1513	229	12	as	as	SCONJ
admet-1513	229	13	they	they	PRON
admet-1513	229	14	can	can	AUX
admet-1513	229	15	estimate	estimate	VERB
admet-1513	229	16	the	the	DET
admet-1513	229	17	exact	exact	ADJ
admet-1513	229	18	transport	transport	NOUN
admet-1513	229	19	mechanism	mechanism	NOUN
admet-1513	229	20	of	of	ADP
admet-1513	229	21	a	a	DET
admet-1513	229	22	drug	drug	NOUN
admet-1513	229	23	or	or	CCONJ
admet-1513	229	24	inhibitor	inhibitor	NOUN
admet-1513	229	25	[	[	X
admet-1513	229	26	89	89	NUM
admet-1513	229	27	]	]	PUNCT
admet-1513	229	28	.	.	PUNCT
admet-1513	230	1	van	van	PROPN
admet-1513	230	2	staden	staden	PROPN
admet-1513	230	3	and	and	CCONJ
admet-1513	230	4	colleagues	colleague	NOUN
admet-1513	231	1	[	[	X
admet-1513	231	2	82	82	NUM
admet-1513	231	3	]	]	PUNCT
admet-1513	231	4	investigated	investigate	VERB
admet-1513	231	5	the	the	DET
admet-1513	231	6	drug	drug	NOUN
admet-1513	231	7	candidates	candidate	NOUN
admet-1513	231	8	affecting	affect	VERB
admet-1513	231	9	transporter	transporter	NOUN
admet-1513	231	10	function	function	NOUN
admet-1513	231	11	and	and	CCONJ
admet-1513	231	12	dili	dili	NOUN
admet-1513	231	13	using	use	VERB
admet-1513	231	14	membrane	membrane	NOUN
admet-1513	231	15	vesicles	vesicle	NOUN
admet-1513	231	16	prepared	prepare	VERB
admet-1513	231	17	from	from	ADP
admet-1513	231	18	hepatocytes	hepatocyte	NOUN
admet-1513	231	19	containing	contain	VERB
admet-1513	231	20	a	a	DET
admet-1513	231	21	bile	bile	NOUN
admet-1513	231	22	salt	salt	NOUN
admet-1513	231	23	export	export	NOUN
admet-1513	231	24	pump	pump	NOUN
admet-1513	231	25	,	,	PUNCT
admet-1513	231	26	mrp	mrp	PROPN
admet-1513	231	27	.	.	PROPN
admet-1513	231	28	cell	cell	NOUN
admet-1513	231	29	-	-	PUNCT
admet-1513	231	30	based	base	VERB
admet-1513	231	31	assays	assay	NOUN
admet-1513	231	32	include	include	VERB
admet-1513	231	33	the	the	DET
admet-1513	231	34	use	use	NOUN
admet-1513	231	35	of	of	ADP
admet-1513	231	36	immortalized	immortalize	VERB
admet-1513	231	37	cell	cell	NOUN
admet-1513	231	38	lines	line	NOUN
admet-1513	231	39	or	or	CCONJ
admet-1513	231	40	primary	primary	ADJ
admet-1513	231	41	isolated	isolated	ADJ
admet-1513	231	42	cells	cell	NOUN
admet-1513	231	43	or	or	CCONJ
admet-1513	231	44	recombinant	recombinant	ADJ
admet-1513	231	45	cell	cell	NOUN
admet-1513	231	46	lines	line	NOUN
admet-1513	231	47	expressing	express	VERB
admet-1513	231	48	transporter	transporter	NOUN
admet-1513	231	49	proteins	protein	NOUN
admet-1513	231	50	.	.	PUNCT
admet-1513	232	1	the	the	DET
admet-1513	232	2	most	most	ADV
admet-1513	232	3	commonly	commonly	ADV
admet-1513	232	4	used	use	VERB
admet-1513	232	5	cell	cell	NOUN
admet-1513	232	6	lines	line	NOUN
admet-1513	232	7	are	be	AUX
admet-1513	232	8	mdckii	mdckii	ADJ
admet-1513	232	9	and	and	CCONJ
admet-1513	232	10	human	human	ADJ
admet-1513	232	11	embryonic	embryonic	ADJ
admet-1513	232	12	kidney	kidney	NOUN
admet-1513	232	13	(	(	PUNCT
admet-1513	232	14	hek	hek	PROPN
admet-1513	232	15	)	)	PUNCT
admet-1513	232	16	293	293	NUM
admet-1513	232	17	cells	cell	NOUN
admet-1513	232	18	.	.	PUNCT
admet-1513	233	1	the	the	DET
admet-1513	233	2	application	application	NOUN
admet-1513	233	3	of	of	ADP
admet-1513	233	4	mdck	mdck	PROPN
admet-1513	233	5	cell	cell	NOUN
admet-1513	233	6	lines	line	NOUN
admet-1513	233	7	has	have	AUX
admet-1513	233	8	already	already	ADV
admet-1513	233	9	been	be	AUX
admet-1513	233	10	provided	provide	VERB
admet-1513	233	11	in	in	ADP
admet-1513	233	12	the	the	DET
admet-1513	233	13	absorption	absorption	NOUN
admet-1513	233	14	section	section	NOUN
admet-1513	233	15	.	.	PUNCT
admet-1513	234	1	hek293	hek293	PROPN
admet-1513	234	2	cells	cell	NOUN
admet-1513	234	3	were	be	AUX
admet-1513	234	4	developed	develop	VERB
admet-1513	234	5	by	by	ADP
admet-1513	234	6	the	the	DET
admet-1513	234	7	transformation	transformation	NOUN
admet-1513	234	8	of	of	ADP
admet-1513	234	9	hek	hek	PROPN
admet-1513	234	10	cells	cell	NOUN
admet-1513	234	11	with	with	ADP
admet-1513	234	12	adenovirus	adenovirus	NOUN
admet-1513	234	13	[	[	X
admet-1513	234	14	90	90	NUM
admet-1513	234	15	]	]	PUNCT
admet-1513	234	16	.	.	PUNCT
admet-1513	235	1	the	the	DET
admet-1513	235	2	primary	primary	ADJ
admet-1513	235	3	advantage	advantage	NOUN
admet-1513	235	4	of	of	ADP
admet-1513	235	5	the	the	DET
admet-1513	235	6	hek293	hek293	PROPN
admet-1513	235	7	cell	cell	NOUN
admet-1513	235	8	line	line	NOUN
admet-1513	235	9	is	be	AUX
admet-1513	235	10	the	the	DET
admet-1513	235	11	low	low	ADJ
admet-1513	235	12	expression	expression	NOUN
admet-1513	235	13	of	of	ADP
admet-1513	235	14	metabolic	metabolic	NOUN
admet-1513	235	15	enzymes	enzyme	NOUN
admet-1513	235	16	and	and	CCONJ
admet-1513	235	17	endogenous	endogenous	ADJ
admet-1513	235	18	transporters	transporter	NOUN
admet-1513	235	19	,	,	PUNCT
admet-1513	235	20	which	which	PRON
admet-1513	235	21	makes	make	VERB
admet-1513	235	22	them	they	PRON
admet-1513	235	23	an	an	DET
admet-1513	235	24	excellent	excellent	ADJ
admet-1513	235	25	source	source	NOUN
admet-1513	235	26	for	for	ADP
admet-1513	235	27	the	the	DET
admet-1513	235	28	generation	generation	NOUN
admet-1513	235	29	of	of	ADP
admet-1513	235	30	recombinant	recombinant	ADJ
admet-1513	235	31	cell	cell	NOUN
admet-1513	235	32	lines	line	NOUN
admet-1513	235	33	which	which	PRON
admet-1513	235	34	can	can	AUX
admet-1513	235	35	express	express	VERB
admet-1513	235	36	exogenous	exogenous	ADJ
admet-1513	235	37	transporters	transporter	NOUN
admet-1513	235	38	[	[	X
admet-1513	235	39	91	91	NUM
admet-1513	235	40	]	]	PUNCT
admet-1513	235	41	.	.	PUNCT
admet-1513	236	1	parvez	parvez	PROPN
admet-1513	236	2	and	and	CCONJ
admet-1513	236	3	colleagues	colleague	NOUN
admet-1513	236	4	[	[	X
admet-1513	236	5	92	92	NUM
admet-1513	236	6	]	]	PUNCT
admet-1513	236	7	stably	stably	ADV
admet-1513	236	8	generated	generate	VERB
admet-1513	236	9	recombinant	recombinant	ADJ
admet-1513	236	10	hek293	hek293	PROPN
admet-1513	236	11	that	that	PRON
admet-1513	236	12	can	can	AUX
admet-1513	236	13	express	express	VERB
admet-1513	236	14	oat1	oat1	PROPN
admet-1513	236	15	,	,	PUNCT
admet-1513	236	16	oat3	oat3	PROPN
admet-1513	236	17	and	and	CCONJ
admet-1513	236	18	oct1/2	oct1/2	ADJ
admet-1513	236	19	transporters	transporter	NOUN
admet-1513	236	20	and	and	CCONJ
admet-1513	236	21	studied	study	VERB
admet-1513	236	22	the	the	DET
admet-1513	236	23	effect	effect	NOUN
admet-1513	236	24	of	of	ADP
admet-1513	236	25	22	22	NUM
admet-1513	236	26	antituberculosis	antituberculosis	NOUN
admet-1513	236	27	drugs	drug	NOUN
admet-1513	236	28	on	on	ADP
admet-1513	236	29	the	the	DET
admet-1513	236	30	uptake	uptake	NOUN
admet-1513	236	31	of	of	ADP
admet-1513	236	32	para	para	NOUN
admet-1513	236	33	-	-	PUNCT
admet-1513	236	34	aminohippurate	aminohippurate	NOUN
admet-1513	236	35	,	,	PUNCT
admet-1513	236	36	n	n	CCONJ
admet-1513	236	37	-	-	PUNCT
admet-1513	236	38	methyl-4	methyl-4	NOUN
admet-1513	236	39	-	-	PUNCT
admet-1513	236	40	phenylpyridinium	phenylpyridinium	NOUN
admet-1513	236	41	acetate	acetate	NOUN
admet-1513	236	42	and	and	CCONJ
admet-1513	236	43	zidovudine	zidovudine	NOUN
admet-1513	236	44	.	.	PUNCT
admet-1513	237	1	their	their	PRON
admet-1513	237	2	results	result	NOUN
admet-1513	237	3	demonstrated	demonstrate	VERB
admet-1513	237	4	the	the	DET
admet-1513	237	5	inhibitory	inhibitory	ADJ
admet-1513	237	6	effects	effect	NOUN
admet-1513	237	7	of	of	ADP
admet-1513	237	8	several	several	ADJ
admet-1513	237	9	antituberculosis	antituberculosis	NOUN
admet-1513	237	10	drugs	drug	NOUN
admet-1513	237	11	on	on	ADP
admet-1513	237	12	these	these	DET
admet-1513	237	13	transporters	transporter	NOUN
admet-1513	237	14	.	.	PUNCT
admet-1513	238	1	3d	3d	NUM
admet-1513	238	2	cell	cell	NOUN
admet-1513	238	3	culture	culture	NOUN
admet-1513	238	4	systems	system	NOUN
admet-1513	238	5	to	to	PART
admet-1513	238	6	evaluate	evaluate	VERB
admet-1513	238	7	adme	adme	NOUN
admet-1513	238	8	-	-	PUNCT
admet-1513	238	9	tox	tox	NOUN
admet-1513	238	10	screening	screening	NOUN
admet-1513	238	11	until	until	ADP
admet-1513	238	12	now	now	ADV
admet-1513	238	13	,	,	PUNCT
admet-1513	238	14	most	most	ADJ
admet-1513	238	15	of	of	ADP
admet-1513	238	16	the	the	DET
admet-1513	238	17	pre	pre	ADJ
admet-1513	238	18	-	-	ADJ
admet-1513	238	19	clinical	clinical	ADJ
admet-1513	238	20	trials	trial	NOUN
admet-1513	238	21	utilized	utilize	VERB
admet-1513	238	22	commercial	commercial	ADJ
admet-1513	238	23	2d	2d	NUM
admet-1513	238	24	cell	cell	NOUN
admet-1513	238	25	lines	line	NOUN
admet-1513	238	26	and	and	CCONJ
admet-1513	238	27	patient	patient	NOUN
admet-1513	238	28	-	-	PUNCT
admet-1513	238	29	derived	derive	VERB
admet-1513	238	30	xenograft	xenograft	NOUN
admet-1513	238	31	models	model	NOUN
admet-1513	238	32	for	for	ADP
admet-1513	238	33	screening	screen	VERB
admet-1513	238	34	compounds	compound	NOUN
admet-1513	238	35	in	in	ADP
admet-1513	238	36	vitro[93	vitro[93	NOUN
admet-1513	238	37	]	]	PUNCT
admet-1513	238	38	.	.	PUNCT
admet-1513	239	1	however	however	ADV
admet-1513	239	2	,	,	PUNCT
admet-1513	239	3	these	these	DET
admet-1513	239	4	models	model	NOUN
admet-1513	239	5	lack	lack	VERB
admet-1513	239	6	complex	complex	ADJ
admet-1513	239	7	in	in	ADP
admet-1513	239	8	vivo	vivo	ADJ
admet-1513	239	9	human	human	ADJ
admet-1513	239	10	environment	environment	NOUN
admet-1513	239	11	niches	niche	NOUN
admet-1513	239	12	and	and	CCONJ
admet-1513	239	13	could	could	AUX
admet-1513	239	14	n’t	not	PART
admet-1513	239	15	give	give	VERB
admet-1513	239	16	conclusive	conclusive	ADJ
admet-1513	239	17	drug	drug	NOUN
admet-1513	239	18	responses	response	NOUN
admet-1513	239	19	.	.	PUNCT
admet-1513	240	1	most	most	ADJ
admet-1513	240	2	of	of	ADP
admet-1513	240	3	the	the	DET
admet-1513	240	4	drugs	drug	NOUN
admet-1513	240	5	that	that	PRON
admet-1513	240	6	passed	pass	VERB
admet-1513	240	7	pre	pre	ADJ
admet-1513	240	8	-	-	ADJ
admet-1513	240	9	clinical	clinical	ADJ
admet-1513	240	10	trials	trial	NOUN
admet-1513	240	11	have	have	VERB
admet-1513	240	12	very	very	ADV
admet-1513	240	13	few	few	ADJ
admet-1513	240	14	success	success	NOUN
admet-1513	240	15	rates	rate	NOUN
admet-1513	240	16	in	in	ADP
admet-1513	240	17	phase	phase	NOUN
admet-1513	240	18	-	-	PUNCT
admet-1513	240	19	ii	ii	NOUN
admet-1513	240	20	and	and	CCONJ
admet-1513	240	21	iii	iii	NUM
admet-1513	240	22	clinical	clinical	ADJ
admet-1513	240	23	trials	trial	NOUN
admet-1513	240	24	because	because	SCONJ
admet-1513	240	25	of	of	ADP
admet-1513	240	26	a	a	DET
admet-1513	240	27	lack	lack	NOUN
admet-1513	240	28	of	of	ADP
admet-1513	240	29	effectiveness	effectiveness	NOUN
admet-1513	240	30	and	and	CCONJ
admet-1513	240	31	safety	safety	NOUN
admet-1513	240	32	[	[	X
admet-1513	240	33	94	94	NUM
admet-1513	240	34	]	]	PUNCT
admet-1513	240	35	.	.	PUNCT
admet-1513	241	1	to	to	PART
admet-1513	241	2	overcome	overcome	VERB
admet-1513	241	3	limitations	limitation	NOUN
admet-1513	241	4	like	like	ADP
admet-1513	241	5	drug	drug	NOUN
admet-1513	241	6	efficacy	efficacy	NOUN
admet-1513	241	7	and	and	CCONJ
admet-1513	241	8	safety	safety	NOUN
admet-1513	241	9	in	in	ADP
admet-1513	241	10	2d	2d	NUM
admet-1513	241	11	cell	cell	NOUN
admet-1513	241	12	culture	culture	NOUN
admet-1513	241	13	techniques	technique	NOUN
admet-1513	241	14	,	,	PUNCT
admet-1513	241	15	scientists	scientist	NOUN
admet-1513	241	16	and	and	CCONJ
admet-1513	241	17	researchers	researcher	NOUN
admet-1513	241	18	were	be	AUX
admet-1513	241	19	committed	commit	VERB
admet-1513	241	20	to	to	ADP
admet-1513	241	21	developing	develop	VERB
admet-1513	241	22	drug	drug	NOUN
admet-1513	241	23	screening	screening	NOUN
admet-1513	241	24	models	model	NOUN
admet-1513	241	25	that	that	PRON
admet-1513	241	26	are	be	AUX
admet-1513	241	27	more	more	ADV
admet-1513	241	28	effective	effective	ADJ
admet-1513	241	29	,	,	PUNCT
admet-1513	241	30	realistic	realistic	ADJ
admet-1513	241	31	,	,	PUNCT
admet-1513	241	32	timesaving	timesaving	ADJ
admet-1513	241	33	,	,	PUNCT
admet-1513	241	34	and	and	CCONJ
admet-1513	241	35	labour	labour	NOUN
admet-1513	241	36	-	-	PUNCT
admet-1513	241	37	saving	saving	NOUN
admet-1513	241	38	for	for	ADP
admet-1513	241	39	studying	study	VERB
admet-1513	241	40	pharmacokinetics	pharmacokinetic	NOUN
admet-1513	241	41	and	and	CCONJ
admet-1513	241	42	pharmacodynamic	pharmacodynamic	ADJ
admet-1513	241	43	processes	process	NOUN
admet-1513	241	44	[	[	X
admet-1513	241	45	95	95	NUM
admet-1513	241	46	]	]	PUNCT
admet-1513	241	47	.	.	PUNCT
admet-1513	242	1	the	the	DET
admet-1513	242	2	morphological	morphological	ADJ
admet-1513	242	3	and	and	CCONJ
admet-1513	242	4	functional	functional	ADJ
admet-1513	242	5	similarity	similarity	NOUN
admet-1513	242	6	between	between	ADP
admet-1513	242	7	in	in	ADP
admet-1513	242	8	vivo	vivo	NOUN
admet-1513	242	9	and	and	CCONJ
admet-1513	242	10	the	the	DET
admet-1513	242	11	cell	cell	NOUN
admet-1513	242	12	grown	grow	VERB
admet-1513	242	13	in	in	ADP
admet-1513	242	14	3d	3d	NUM
admet-1513	242	15	culture	culture	NOUN
admet-1513	242	16	conditions	condition	NOUN
admet-1513	242	17	have	have	AUX
admet-1513	242	18	established	establish	VERB
admet-1513	242	19	3d	3d	NUM
admet-1513	242	20	models	model	NOUN
admet-1513	242	21	as	as	ADP
admet-1513	242	22	a	a	DET
admet-1513	242	23	valuable	valuable	ADJ
admet-1513	242	24	option	option	NOUN
admet-1513	242	25	.	.	PUNCT
admet-1513	243	1	as	as	ADP
admet-1513	243	2	a	a	DET
admet-1513	243	3	result	result	NOUN
admet-1513	243	4	,	,	PUNCT
admet-1513	243	5	3d	3d	NUM
admet-1513	243	6	models	model	NOUN
admet-1513	243	7	are	be	AUX
admet-1513	243	8	considered	consider	VERB
admet-1513	243	9	to	to	PART
admet-1513	243	10	have	have	VERB
admet-1513	243	11	a	a	DET
admet-1513	243	12	significant	significant	ADJ
admet-1513	243	13	impact	impact	NOUN
admet-1513	243	14	on	on	ADP
admet-1513	243	15	drug	drug	NOUN
admet-1513	243	16	screening	screening	NOUN
admet-1513	243	17	,	,	PUNCT
admet-1513	243	18	bridging	bridge	VERB
admet-1513	243	19	the	the	DET
admet-1513	243	20	gap	gap	NOUN
admet-1513	243	21	between	between	ADP
admet-1513	243	22	cell	cell	NOUN
admet-1513	243	23	cultures	culture	NOUN
admet-1513	243	24	and	and	CCONJ
admet-1513	243	25	animal	animal	NOUN
admet-1513	243	26	models	model	NOUN
admet-1513	243	27	and	and	CCONJ
admet-1513	243	28	potentially	potentially	ADV
admet-1513	243	29	reducing	reduce	VERB
admet-1513	243	30	the	the	DET
admet-1513	243	31	usage	usage	NOUN
admet-1513	243	32	of	of	ADP
admet-1513	243	33	animals	animal	NOUN
admet-1513	243	34	in	in	ADP
admet-1513	243	35	research	research	NOUN
admet-1513	243	36	[	[	X
admet-1513	243	37	96	96	NUM
admet-1513	243	38	]	]	PUNCT
admet-1513	243	39	.	.	PUNCT
admet-1513	244	1	the	the	DET
admet-1513	244	2	major	major	ADJ
admet-1513	244	3	pros	pro	NOUN
admet-1513	244	4	and	and	CCONJ
admet-1513	244	5	cons	con	NOUN
admet-1513	244	6	between	between	ADP
admet-1513	244	7	the	the	DET
admet-1513	244	8	2d	2d	NOUN
admet-1513	244	9	and	and	CCONJ
admet-1513	244	10	3d	3d	NUM
admet-1513	244	11	cell	cell	NOUN
admet-1513	244	12	culture	culture	NOUN
admet-1513	244	13	models	model	NOUN
admet-1513	244	14	are	be	AUX
admet-1513	244	15	tabulated	tabulate	VERB
admet-1513	244	16	in	in	ADP
admet-1513	244	17	table	table	NOUN
admet-1513	244	18	1	1	NUM
admet-1513	244	19	.	.	PUNCT
admet-1513	244	20	organoids	organoid	NOUN
admet-1513	244	21	are	be	AUX
admet-1513	244	22	self	self	NOUN
admet-1513	244	23	-	-	PUNCT
admet-1513	244	24	organizing	organize	VERB
admet-1513	244	25	3d	3d	NUM
admet-1513	244	26	cell	cell	NOUN
admet-1513	244	27	cultures	culture	NOUN
admet-1513	244	28	with	with	ADP
admet-1513	244	29	a	a	DET
admet-1513	244	30	realistic	realistic	ADJ
admet-1513	244	31	microanatomy	microanatomy	NOUN
admet-1513	244	32	due	due	ADP
admet-1513	244	33	to	to	ADP
admet-1513	244	34	their	their	PRON
admet-1513	244	35	in	in	ADP
admet-1513	244	36	vivo	vivo	NOUN
admet-1513	244	37	-	-	PUNCT
admet-1513	244	38	like	like	ADJ
admet-1513	244	39	self	self	NOUN
admet-1513	244	40	-	-	PUNCT
admet-1513	244	41	organizing	organize	VERB
admet-1513	244	42	and	and	CCONJ
admet-1513	244	43	self	self	NOUN
admet-1513	244	44	-	-	PUNCT
admet-1513	244	45	renewing	renew	VERB
admet-1513	244	46	capacities	capacity	NOUN
admet-1513	244	47	[	[	X
admet-1513	244	48	97	97	NUM
admet-1513	244	49	]	]	PUNCT
admet-1513	244	50	.	.	PUNCT
admet-1513	245	1	they	they	PRON
admet-1513	245	2	revolutionized	revolutionize	VERB
admet-1513	245	3	tissue	tissue	NOUN
admet-1513	245	4	engineering	engineering	NOUN
admet-1513	245	5	by	by	ADP
admet-1513	245	6	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	245	7	venkatesh	venkatesh	PROPN
admet-1513	245	8	chunduri	chunduri	PROPN
admet-1513	245	9	and	and	CCONJ
admet-1513	245	10	srinivas	srinivas	PROPN
admet-1513	245	11	maddi	maddi	PROPN
admet-1513	245	12	admet	admet	PROPN
admet-1513	245	13	&	&	CCONJ
admet-1513	245	14	dmpk	dmpk	PROPN
admet-1513	245	15	11(1	11(1	NUM
admet-1513	245	16	)	)	PUNCT
admet-1513	245	17	(	(	PUNCT
admet-1513	245	18	2023	2023	NUM
admet-1513	245	19	)	)	PUNCT
admet-1513	245	20	1	1	NUM
admet-1513	245	21	-	-	SYM
admet-1513	245	22	32	32	NUM
admet-1513	245	23	10	10	NUM
admet-1513	245	24	maintaining	maintain	VERB
admet-1513	245	25	cellular	cellular	ADJ
admet-1513	245	26	complexity	complexity	NOUN
admet-1513	245	27	,	,	PUNCT
admet-1513	245	28	which	which	PRON
admet-1513	245	29	is	be	AUX
admet-1513	245	30	comparable	comparable	ADJ
admet-1513	245	31	to	to	ADP
admet-1513	245	32	that	that	PRON
admet-1513	245	33	of	of	ADP
admet-1513	245	34	native	native	ADJ
admet-1513	245	35	organs	organ	NOUN
admet-1513	245	36	[	[	X
admet-1513	245	37	98	98	NUM
admet-1513	245	38	]	]	PUNCT
admet-1513	245	39	.	.	PUNCT
admet-1513	246	1	these	these	DET
admet-1513	246	2	3d	3d	PROPN
admet-1513	246	3	structures	structure	NOUN
admet-1513	246	4	are	be	AUX
admet-1513	246	5	generated	generate	VERB
admet-1513	246	6	by	by	ADP
admet-1513	246	7	differentiated	differentiated	ADJ
admet-1513	246	8	pluripotent	pluripotent	ADJ
admet-1513	246	9	stem	stem	NOUN
admet-1513	246	10	cells	cell	NOUN
admet-1513	246	11	(	(	PUNCT
admet-1513	246	12	pscs	psc	NOUN
admet-1513	246	13	)	)	PUNCT
admet-1513	246	14	,	,	PUNCT
admet-1513	246	15	primary	primary	ADJ
admet-1513	246	16	adult	adult	NOUN
admet-1513	246	17	tissues	tissue	NOUN
admet-1513	246	18	,	,	PUNCT
admet-1513	246	19	tumours	tumour	NOUN
admet-1513	246	20	and	and	CCONJ
admet-1513	246	21	fetal	fetal	ADJ
admet-1513	246	22	tissues	tissue	NOUN
admet-1513	246	23	[	[	X
admet-1513	246	24	99	99	NUM
admet-1513	246	25	]	]	PUNCT
admet-1513	246	26	.	.	PUNCT
admet-1513	247	1	among	among	ADP
admet-1513	247	2	them	they	PRON
admet-1513	247	3	,	,	PUNCT
admet-1513	247	4	human	human	NOUN
admet-1513	247	5	-	-	PUNCT
admet-1513	247	6	induced	induce	VERB
admet-1513	247	7	pscs	psc	NOUN
admet-1513	247	8	(	(	PUNCT
admet-1513	247	9	hipscs	hipsc	NOUN
admet-1513	247	10	)	)	PUNCT
admet-1513	247	11	are	be	AUX
admet-1513	247	12	gaining	gain	VERB
admet-1513	247	13	much	much	ADJ
admet-1513	247	14	importance	importance	NOUN
admet-1513	247	15	in	in	ADP
admet-1513	247	16	disease	disease	NOUN
admet-1513	247	17	research	research	NOUN
admet-1513	247	18	,	,	PUNCT
admet-1513	247	19	generating	generate	VERB
admet-1513	247	20	disease	disease	NOUN
admet-1513	247	21	-	-	PUNCT
admet-1513	247	22	specific	specific	ADJ
admet-1513	247	23	hipscs	hipsc	NOUN
admet-1513	247	24	and	and	CCONJ
admet-1513	247	25	as	as	ADP
admet-1513	247	26	a	a	DET
admet-1513	247	27	source	source	NOUN
admet-1513	247	28	of	of	ADP
admet-1513	247	29	continuous	continuous	ADJ
admet-1513	247	30	supply	supply	NOUN
admet-1513	247	31	of	of	ADP
admet-1513	247	32	human	human	ADJ
admet-1513	247	33	cells	cell	NOUN
admet-1513	247	34	that	that	PRON
admet-1513	247	35	are	be	AUX
admet-1513	247	36	not	not	PART
admet-1513	247	37	often	often	ADV
admet-1513	247	38	available	available	ADJ
admet-1513	247	39	[	[	X
admet-1513	247	40	100	100	NUM
admet-1513	247	41	]	]	PUNCT
admet-1513	247	42	.	.	PUNCT
admet-1513	248	1	table	table	NOUN
admet-1513	248	2	1	1	NUM
admet-1513	248	3	.	.	PUNCT
admet-1513	249	1	a	a	DET
admet-1513	249	2	comparison	comparison	NOUN
admet-1513	249	3	between	between	ADP
admet-1513	249	4	2d	2d	NOUN
admet-1513	249	5	and	and	CCONJ
admet-1513	249	6	3d	3d	NUM
admet-1513	249	7	in	in	ADP
admet-1513	249	8	vitro	vitro	X
admet-1513	249	9	models	model	NOUN
admet-1513	249	10	for	for	ADP
admet-1513	249	11	adme	adme	NOUN
admet-1513	249	12	-	-	PUNCT
admet-1513	249	13	tox	tox	NOUN
admet-1513	249	14	screening	screening	NOUN
admet-1513	249	15	model	model	NOUN
admet-1513	249	16	pros	pros	PROPN
admet-1513	249	17	cons	con	NOUN
admet-1513	249	18	2d	2d	NUM
admet-1513	249	19	cell	cell	NOUN
admet-1513	249	20	cultures	culture	NOUN
admet-1513	249	21			NOUN
admet-1513	249	22	ease	ease	NOUN
admet-1513	249	23	of	of	ADP
admet-1513	249	24	handling	handling	NOUN
admet-1513	249	25	,	,	PUNCT
admet-1513	249	26	interpretation	interpretation	NOUN
admet-1513	249	27	and	and	CCONJ
admet-1513	249	28	manipulation	manipulation	NOUN
admet-1513	249	29	.	.	PUNCT
admet-1513	250	1			NOUN
admet-1513	251	1	less	less	ADJ
admet-1513	251	2	training	training	NOUN
admet-1513	251	3	required	require	VERB
admet-1513	251	4	.	.	PUNCT
admet-1513	252	1			NOUN
admet-1513	252	2	economical	economical	ADJ
admet-1513	252	3	.	.	PUNCT
admet-1513	253	1			PRON
admet-1513	253	2	can	can	AUX
admet-1513	253	3	be	be	AUX
admet-1513	253	4	used	use	VERB
admet-1513	253	5	for	for	ADP
admet-1513	253	6	high	high	ADJ
admet-1513	253	7	throughput	throughput	NOUN
admet-1513	253	8	screening	screening	NOUN
admet-1513	253	9	.	.	PUNCT
admet-1513	254	1			X
admet-1513	254	2	less	less	ADV
admet-1513	254	3	inter	inter	ADJ
admet-1513	254	4	-	-	ADJ
admet-1513	254	5	lab	lab	ADJ
admet-1513	254	6	variation	variation	NOUN
admet-1513	254	7	.	.	PUNCT
admet-1513	255	1			NOUN
admet-1513	255	2	reproducibility	reproducibility	NOUN
admet-1513	255	3	.	.	PUNCT
admet-1513	256	1			X
admet-1513	256	2	long	long	ADJ
admet-1513	256	3	-	-	PUNCT
admet-1513	256	4	term	term	NOUN
admet-1513	256	5	storage	storage	NOUN
admet-1513	256	6	.	.	PUNCT
admet-1513	257	1			X
admet-1513	257	2	mostly	mostly	ADV
admet-1513	257	3	cancerous	cancerous	ADJ
admet-1513	257	4	origin	origin	NOUN
admet-1513	257	5	.	.	PUNCT
admet-1513	258	1			NOUN
admet-1513	258	2	less	less	ADV
admet-1513	258	3	physiological	physiological	ADJ
admet-1513	258	4	relevance	relevance	NOUN
admet-1513	258	5	and	and	CCONJ
admet-1513	258	6	lack	lack	NOUN
admet-1513	258	7	of	of	ADP
admet-1513	258	8	complex	complex	NOUN
admet-1513	258	9	in	in	ADP
admet-1513	258	10	vivo	vivo	ADJ
admet-1513	258	11	niches	niche	NOUN
admet-1513	258	12	.	.	PUNCT
admet-1513	259	1			NOUN
admet-1513	259	2	absence	absence	NOUN
admet-1513	259	3	or	or	CCONJ
admet-1513	259	4	limited	limited	ADJ
admet-1513	259	5	production	production	NOUN
admet-1513	259	6	of	of	ADP
admet-1513	259	7	enzymes	enzyme	NOUN
admet-1513	259	8	and	and	CCONJ
admet-1513	259	9	transporters	transporter	NOUN
admet-1513	259	10	.	.	PUNCT
admet-1513	260	1			PRON
admet-1513	260	2	not	not	PART
admet-1513	260	3	capable	capable	ADJ
admet-1513	260	4	of	of	ADP
admet-1513	260	5	mimicking	mimic	VERB
admet-1513	260	6	the	the	DET
admet-1513	260	7	in	in	ADP
admet-1513	260	8	vivo	vivo	ADJ
admet-1513	260	9	anatomical	anatomical	ADJ
admet-1513	260	10	,	,	PUNCT
admet-1513	260	11	biochemical	biochemical	ADJ
admet-1513	260	12	and	and	CCONJ
admet-1513	260	13	structural	structural	ADJ
admet-1513	260	14	features	feature	NOUN
admet-1513	260	15	.	.	PUNCT
admet-1513	261	1			X
admet-1513	261	2	poor	poor	ADJ
admet-1513	261	3	drug	drug	NOUN
admet-1513	261	4	metabolism	metabolism	NOUN
admet-1513	261	5	.	.	PUNCT
admet-1513	262	1			X
admet-1513	262	2	ca	can	AUX
admet-1513	262	3	n’t	not	PART
admet-1513	262	4	predict	predict	VERB
admet-1513	262	5	conclusively	conclusively	ADV
admet-1513	262	6	in	in	ADP
admet-1513	262	7	vivo	vivo	ADJ
admet-1513	262	8	adme	adme	NOUN
admet-1513	262	9	-	-	PUNCT
admet-1513	262	10	tox	tox	NOUN
admet-1513	262	11	properties	property	NOUN
admet-1513	262	12	.	.	PUNCT
admet-1513	263	1	3d	3d	NUM
admet-1513	263	2	organoids	organoid	NOUN
admet-1513	263	3			PRON
admet-1513	263	4	self	self	NOUN
admet-1513	263	5	-	-	PUNCT
admet-1513	263	6	organized	organize	VERB
admet-1513	263	7	and	and	CCONJ
admet-1513	263	8	physiological	physiological	ADJ
admet-1513	263	9	similarity	similarity	NOUN
admet-1513	263	10	to	to	ADP
admet-1513	263	11	that	that	PRON
admet-1513	263	12	of	of	ADP
admet-1513	263	13	in	in	ADP
admet-1513	263	14	vivo	vivo	ADJ
admet-1513	263	15	tissues	tissue	NOUN
admet-1513	263	16	and	and	CCONJ
admet-1513	263	17	organs	organ	NOUN
admet-1513	263	18	.	.	PUNCT
admet-1513	264	1			NOUN
admet-1513	264	2	ability	ability	NOUN
admet-1513	264	3	for	for	ADP
admet-1513	264	4	indefinite	indefinite	ADJ
admet-1513	264	5	expansion	expansion	NOUN
admet-1513	264	6	and	and	CCONJ
admet-1513	264	7	storage	storage	NOUN
admet-1513	264	8	.	.	PUNCT
admet-1513	265	1			NOUN
admet-1513	265	2	reproduction	reproduction	NOUN
admet-1513	265	3	of	of	ADP
admet-1513	265	4	cellular	cellular	ADJ
admet-1513	265	5	heterogeneity	heterogeneity	NOUN
admet-1513	265	6	and	and	CCONJ
admet-1513	265	7	cell	cell	NOUN
admet-1513	265	8	-	-	PUNCT
admet-1513	265	9	cell	cell	NOUN
admet-1513	265	10	interactions	interaction	NOUN
admet-1513	265	11	.	.	PUNCT
admet-1513	266	1			NOUN
admet-1513	266	2	absence	absence	NOUN
admet-1513	266	3	of	of	ADP
admet-1513	266	4	cancerous	cancerous	ADJ
admet-1513	266	5	cells	cell	NOUN
admet-1513	266	6	.	.	PUNCT
admet-1513	267	1			X
admet-1513	267	2	high	high	ADJ
admet-1513	267	3	expression	expression	NOUN
admet-1513	267	4	of	of	ADP
admet-1513	267	5	tissue	tissue	NOUN
admet-1513	267	6	-	-	PUNCT
admet-1513	267	7	related	relate	VERB
admet-1513	267	8	enzymes	enzyme	NOUN
admet-1513	267	9	and	and	CCONJ
admet-1513	267	10	transporters	transporter	NOUN
admet-1513	267	11	.	.	PUNCT
admet-1513	268	1			PRON
admet-1513	268	2	can	can	AUX
admet-1513	268	3	be	be	AUX
admet-1513	268	4	used	use	VERB
admet-1513	268	5	for	for	ADP
admet-1513	268	6	high	high	ADJ
admet-1513	268	7	-	-	PUNCT
admet-1513	268	8	throughput	throughput	NOUN
admet-1513	268	9	screening	screening	NOUN
admet-1513	268	10	.	.	PUNCT
admet-1513	269	1			X
admet-1513	269	2	similar	similar	ADJ
admet-1513	269	3	gene	gene	NOUN
admet-1513	269	4	expression	expression	NOUN
admet-1513	269	5	profiles	profile	NOUN
admet-1513	269	6	as	as	ADP
admet-1513	269	7	that	that	PRON
admet-1513	269	8	of	of	ADP
admet-1513	269	9	in	in	ADP
admet-1513	269	10	vivo	vivo	NOUN
admet-1513	269	11	.	.	PUNCT
admet-1513	270	1			PRON
admet-1513	270	2	disease	disease	NOUN
admet-1513	270	3	modeling	modeling	NOUN
admet-1513	270	4	and	and	CCONJ
admet-1513	270	5	development	development	NOUN
admet-1513	270	6	of	of	ADP
admet-1513	270	7	disease	disease	NOUN
admet-1513	270	8	markers	marker	NOUN
admet-1513	270	9	.	.	PUNCT
admet-1513	271	1			NOUN
admet-1513	271	2	drug	drug	NOUN
admet-1513	271	3	screening	screen	VERB
admet-1513	271	4	for	for	ADP
admet-1513	271	5	personalized	personalized	ADJ
admet-1513	271	6	therapy	therapy	NOUN
admet-1513	271	7	in	in	ADP
admet-1513	271	8	case	case	NOUN
admet-1513	271	9	of	of	ADP
admet-1513	271	10	cancerous	cancerous	ADJ
admet-1513	271	11	patients	patient	NOUN
admet-1513	271	12	.	.	PUNCT
admet-1513	272	1			NOUN
admet-1513	272	2	handling	handling	NOUN
admet-1513	272	3	expertise	expertise	NOUN
admet-1513	272	4	is	be	AUX
admet-1513	272	5	required	require	VERB
admet-1513	272	6	.	.	PUNCT
admet-1513	273	1			X
admet-1513	273	2	expensive	expensive	ADJ
admet-1513	273	3	.	.	PUNCT
admet-1513	274	1			X
admet-1513	274	2	complex	complex	ADJ
admet-1513	274	3	experimental	experimental	ADJ
admet-1513	274	4	techniques	technique	NOUN
admet-1513	274	5	.	.	PUNCT
admet-1513	275	1			NOUN
admet-1513	275	2	culture	culture	NOUN
admet-1513	275	3	formation	formation	NOUN
admet-1513	275	4	is	be	AUX
admet-1513	275	5	time	time	NOUN
admet-1513	275	6	-	-	PUNCT
admet-1513	275	7	consuming	consume	VERB
admet-1513	275	8	.	.	PUNCT
admet-1513	276	1	3d	3d	NUM
admet-1513	276	2	micro	micro	ADJ
admet-1513	276	3	-	-	ADJ
admet-1513	276	4	physiological	physiological	ADJ
admet-1513	276	5	systems	system	NOUN
admet-1513	276	6			NOUN
admet-1513	276	7	physiological	physiological	ADJ
admet-1513	276	8	environment	environment	NOUN
admet-1513	276	9	similarity	similarity	NOUN
admet-1513	276	10	.	.	PUNCT
admet-1513	277	1			X
admet-1513	277	2	can	can	AUX
admet-1513	277	3	be	be	AUX
admet-1513	277	4	developed	develop	VERB
admet-1513	277	5	using	use	VERB
admet-1513	277	6	either	either	CCONJ
admet-1513	277	7	2d	2d	NUM
admet-1513	277	8	cell	cell	NOUN
admet-1513	277	9	cultures	culture	NOUN
admet-1513	277	10	or	or	CCONJ
admet-1513	277	11	3d	3d	NUM
admet-1513	277	12	organoids	organoid	NOUN
admet-1513	277	13	.	.	PUNCT
admet-1513	278	1			X
admet-1513	278	2	able	able	ADJ
admet-1513	278	3	to	to	PART
admet-1513	278	4	achieve	achieve	VERB
admet-1513	278	5	physiological	physiological	ADJ
admet-1513	278	6	fluid	fluid	NOUN
admet-1513	278	7	flow	flow	NOUN
admet-1513	278	8	levels	level	NOUN
admet-1513	278	9	and	and	CCONJ
admet-1513	278	10	shear	shear	NOUN
admet-1513	278	11	forces	force	NOUN
admet-1513	278	12			NOUN
admet-1513	278	13	can	can	AUX
admet-1513	278	14	be	be	AUX
admet-1513	278	15	used	use	VERB
admet-1513	278	16	to	to	PART
admet-1513	278	17	develop	develop	VERB
admet-1513	278	18	multi	multi	ADJ
admet-1513	278	19	-	-	ADJ
admet-1513	278	20	organ	organ	ADJ
admet-1513	278	21	chip	chip	NOUN
admet-1513	278	22	models	model	NOUN
admet-1513	278	23	.	.	PUNCT
admet-1513	279	1			X
admet-1513	279	2	conclusive	conclusive	ADJ
admet-1513	279	3	prediction	prediction	NOUN
admet-1513	279	4	of	of	ADP
admet-1513	279	5	adme	adme	NOUN
admet-1513	279	6	-	-	PUNCT
admet-1513	279	7	tox	tox	NOUN
admet-1513	279	8	fate	fate	NOUN
admet-1513	279	9	of	of	ADP
admet-1513	279	10	a	a	DET
admet-1513	279	11	compound	compound	NOUN
admet-1513	279	12	.	.	PUNCT
admet-1513	280	1			NOUN
admet-1513	280	2	complex	complex	ADJ
admet-1513	280	3	fabrication	fabrication	NOUN
admet-1513	280	4	process	process	NOUN
admet-1513	280	5	for	for	ADP
admet-1513	280	6	model	model	NOUN
admet-1513	280	7	development	development	NOUN
admet-1513	280	8	.	.	PUNCT
admet-1513	281	1			X
admet-1513	281	2	sophisticated	sophisticated	ADJ
admet-1513	281	3	environment	environment	NOUN
admet-1513	281	4	is	be	AUX
admet-1513	281	5	required	require	VERB
admet-1513	281	6	.	.	PUNCT
admet-1513	282	1			ADJ
admet-1513	282	2	highly	highly	ADV
admet-1513	282	3	skilled	skilled	ADJ
admet-1513	282	4	expertise	expertise	NOUN
admet-1513	282	5	.	.	PUNCT
admet-1513	283	1			X
admet-1513	283	2	very	very	ADV
admet-1513	283	3	expensive	expensive	ADJ
admet-1513	283	4	.	.	PUNCT
admet-1513	284	1			PRON
admet-1513	284	2	less	less	ADV
admet-1513	284	3	scalable	scalable	ADJ
admet-1513	284	4	.	.	PUNCT
admet-1513	285	1	intestinal	intestinal	ADJ
admet-1513	285	2	models	model	NOUN
admet-1513	285	3	for	for	ADP
admet-1513	285	4	drug	drug	NOUN
admet-1513	285	5	absorption	absorption	NOUN
admet-1513	285	6	differentiating	differentiating	NOUN
admet-1513	285	7	procedures	procedure	NOUN
admet-1513	285	8	for	for	ADP
admet-1513	285	9	generating	generate	VERB
admet-1513	285	10	intestinal	intestinal	ADJ
admet-1513	285	11	organoids	organoid	NOUN
admet-1513	285	12	or	or	CCONJ
admet-1513	285	13	enteroids	enteroid	NOUN
admet-1513	285	14	[	[	X
admet-1513	285	15	101	101	NUM
admet-1513	285	16	]	]	PUNCT
admet-1513	285	17	and	and	CCONJ
admet-1513	285	18	iecs	iec	NOUN
admet-1513	285	19	[	[	X
admet-1513	285	20	102	102	NUM
admet-1513	285	21	]	]	PUNCT
admet-1513	285	22	from	from	ADP
admet-1513	285	23	hipscs	hipsc	NOUN
admet-1513	285	24	were	be	AUX
admet-1513	285	25	successfully	successfully	ADV
admet-1513	285	26	reported	report	VERB
admet-1513	285	27	.	.	PUNCT
admet-1513	286	1	to	to	ADP
admet-1513	286	2	date	date	NOUN
admet-1513	286	3	,	,	PUNCT
admet-1513	286	4	many	many	ADJ
admet-1513	286	5	researchers	researcher	NOUN
admet-1513	286	6	generated	generate	VERB
admet-1513	286	7	hipscs	hipsc	NOUN
admet-1513	286	8	-	-	PUNCT
admet-1513	286	9	derived	derive	VERB
admet-1513	286	10	organoid	organoid	NOUN
admet-1513	286	11	cultures	culture	NOUN
admet-1513	286	12	involving	involve	VERB
admet-1513	286	13	different	different	ADJ
admet-1513	286	14	organs	organ	NOUN
admet-1513	286	15	of	of	ADP
admet-1513	286	16	the	the	DET
admet-1513	286	17	gastrointestinal	gastrointestinal	ADJ
admet-1513	286	18	tract	tract	NOUN
admet-1513	286	19	,	,	PUNCT
admet-1513	286	20	such	such	ADJ
admet-1513	286	21	as	as	ADP
admet-1513	286	22	the	the	DET
admet-1513	286	23	stomach	stomach	NOUN
admet-1513	287	1	[	[	X
admet-1513	287	2	103	103	NUM
admet-1513	287	3	]	]	PUNCT
admet-1513	287	4	,	,	PUNCT
admet-1513	287	5	pancreas	pancrea	NOUN
admet-1513	287	6	[	[	X
admet-1513	287	7	104	104	NUM
admet-1513	287	8	]	]	PUNCT
admet-1513	287	9	and	and	CCONJ
admet-1513	287	10	intestine	intestine	VERB
admet-1513	287	11	[	[	X
admet-1513	287	12	105,106	105,106	NUM
admet-1513	287	13	]	]	PUNCT
admet-1513	287	14	.	.	PUNCT
admet-1513	288	1	among	among	ADP
admet-1513	288	2	them	they	PRON
admet-1513	288	3	,	,	PUNCT
admet-1513	288	4	enteroids	enteroid	NOUN
admet-1513	288	5	are	be	AUX
admet-1513	288	6	gaining	gain	VERB
admet-1513	288	7	much	much	ADJ
admet-1513	288	8	focus	focus	NOUN
admet-1513	288	9	in	in	ADP
admet-1513	288	10	studying	study	VERB
admet-1513	288	11	drug	drug	NOUN
admet-1513	288	12	permeability	permeability	NOUN
admet-1513	288	13	and	and	CCONJ
admet-1513	288	14	pathophysiological	pathophysiological	ADJ
admet-1513	288	15	mechanisms	mechanism	NOUN
admet-1513	288	16	[	[	X
admet-1513	288	17	5	5	NUM
admet-1513	288	18	]	]	PUNCT
admet-1513	288	19	.	.	PUNCT
admet-1513	289	1	for	for	ADP
admet-1513	289	2	studying	study	VERB
admet-1513	289	3	intestinal	intestinal	ADJ
admet-1513	289	4	drug	drug	NOUN
admet-1513	289	5	absorption	absorption	NOUN
admet-1513	289	6	,	,	PUNCT
admet-1513	289	7	an	an	DET
admet-1513	289	8	in	in	ADP
admet-1513	289	9	vitro	vitro	X
admet-1513	289	10	-	-	PUNCT
admet-1513	289	11	grown	grow	VERB
admet-1513	289	12	enteroid	enteroid	NOUN
admet-1513	289	13	needs	need	VERB
admet-1513	289	14	to	to	PART
admet-1513	289	15	structurally	structurally	ADV
admet-1513	289	16	and	and	CCONJ
admet-1513	289	17	functionally	functionally	ADV
admet-1513	289	18	resemble	resemble	VERB
admet-1513	289	19	human	human	ADJ
admet-1513	289	20	intestinal	intestinal	ADJ
admet-1513	289	21	epithelium	epithelium	NOUN
admet-1513	289	22	and	and	CCONJ
admet-1513	289	23	they	they	PRON
admet-1513	289	24	should	should	AUX
admet-1513	289	25	be	be	AUX
admet-1513	289	26	cultured	cultured	ADJ
admet-1513	289	27	for	for	ADP
admet-1513	289	28	longer	long	ADJ
admet-1513	289	29	periods	period	NOUN
admet-1513	289	30	[	[	X
admet-1513	289	31	107	107	NUM
admet-1513	289	32	]	]	PUNCT
admet-1513	289	33	.	.	PUNCT
admet-1513	290	1	enteroids	enteroid	NOUN
admet-1513	290	2	derived	derive	VERB
admet-1513	290	3	from	from	ADP
admet-1513	290	4	hipsc	hipsc	NOUN
admet-1513	290	5	followed	follow	VERB
admet-1513	290	6	three	three	NUM
admet-1513	290	7	different	different	ADJ
admet-1513	290	8	steps	step	NOUN
admet-1513	290	9	.	.	PUNCT
admet-1513	291	1	the	the	DET
admet-1513	291	2	first	first	ADJ
admet-1513	291	3	is	be	AUX
admet-1513	291	4	differentiation	differentiation	NOUN
admet-1513	291	5	into	into	ADP
admet-1513	291	6	definitive	definitive	ADJ
admet-1513	291	7	endodermal	endodermal	ADJ
admet-1513	291	8	cells	cell	NOUN
admet-1513	291	9	by	by	ADP
admet-1513	291	10	activin	activin	PROPN
admet-1513	291	11	a	a	PRON
admet-1513	292	1	[	[	X
admet-1513	292	2	108	108	NUM
admet-1513	292	3	]	]	PUNCT
admet-1513	292	4	,	,	PUNCT
admet-1513	292	5	followed	follow	VERB
admet-1513	292	6	by	by	ADP
admet-1513	292	7	differentiation	differentiation	NOUN
admet-1513	292	8	into	into	ADP
admet-1513	292	9	midgut	midgut	NOUN
admet-1513	292	10	and	and	CCONJ
admet-1513	292	11	hindgut	hindgut	NOUN
admet-1513	292	12	with	with	ADP
admet-1513	292	13	the	the	DET
admet-1513	292	14	help	help	NOUN
admet-1513	292	15	of	of	ADP
admet-1513	292	16	fibroblast	fibroblast	ADJ
admet-1513	292	17	growth	growth	NOUN
admet-1513	292	18	factor	factor	NOUN
admet-1513	292	19	(	(	PUNCT
admet-1513	292	20	fgf4	fgf4	PROPN
admet-1513	292	21	)	)	PUNCT
admet-1513	292	22	and	and	CCONJ
admet-1513	292	23	wnt3a	wnt3a	PROPN
admet-1513	292	24	and	and	CCONJ
admet-1513	292	25	finally	finally	ADV
admet-1513	292	26	,	,	PUNCT
admet-1513	292	27	intestinal	intestinal	ADJ
admet-1513	292	28	differentiation	differentiation	NOUN
admet-1513	292	29	by	by	ADP
admet-1513	292	30	using	use	VERB
admet-1513	292	31	r	r	NOUN
admet-1513	292	32	-	-	PUNCT
admet-1513	292	33	spondin1	spondin1	NOUN
admet-1513	292	34	,	,	PUNCT
admet-1513	292	35	admet	admet	PROPN
admet-1513	292	36	&	&	CCONJ
admet-1513	292	37	dmpk	dmpk	PROPN
admet-1513	292	38	11(1	11(1	NUM
admet-1513	292	39	)	)	PUNCT
admet-1513	292	40	(	(	PUNCT
admet-1513	292	41	2023	2023	NUM
admet-1513	292	42	)	)	PUNCT
admet-1513	292	43	1	1	NUM
admet-1513	292	44	-	-	SYM
admet-1513	292	45	32	32	NUM
admet-1513	292	46	2d	2d	NOUN
admet-1513	292	47	and	and	CCONJ
admet-1513	292	48	3d	3d	NOUN
admet-1513	292	49	adme	adme	PROPN
admet-1513	292	50	-	-	PUNCT
admet-1513	292	51	tox	tox	NOUN
admet-1513	292	52	cell	cell	NOUN
admet-1513	292	53	culture	culture	NOUN
admet-1513	292	54	screening	screen	VERB
admet-1513	292	55	:	:	PUNCT
admet-1513	292	56	a	a	DET
admet-1513	292	57	review	review	NOUN
admet-1513	292	58	doi	doi	NOUN
admet-1513	292	59	:	:	PUNCT
admet-1513	292	60	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	292	61	11	11	NUM
admet-1513	292	62	noggin	noggin	NOUN
admet-1513	292	63	and	and	CCONJ
admet-1513	292	64	human	human	ADJ
admet-1513	292	65	epidermal	epidermal	ADJ
admet-1513	292	66	growth	growth	NOUN
admet-1513	292	67	factor	factor	NOUN
admet-1513	292	68	(	(	PUNCT
admet-1513	292	69	egf	egf	PROPN
admet-1513	292	70	)	)	PUNCT
admet-1513	292	71	.	.	PUNCT
admet-1513	293	1	in	in	ADP
admet-1513	293	2	addition	addition	NOUN
admet-1513	293	3	,	,	PUNCT
admet-1513	293	4	the	the	DET
admet-1513	293	5	treatment	treatment	NOUN
admet-1513	293	6	with	with	ADP
admet-1513	293	7	r	r	NOUN
admet-1513	293	8	-	-	PUNCT
admet-1513	293	9	spondin1	spondin1	NOUN
admet-1513	293	10	,	,	PUNCT
admet-1513	293	11	noggin	noggin	NOUN
admet-1513	293	12	and	and	CCONJ
admet-1513	293	13	egf	egf	PROPN
admet-1513	293	14	also	also	ADV
admet-1513	293	15	proliferates	proliferate	VERB
admet-1513	293	16	human	human	ADJ
admet-1513	293	17	iecs	iec	NOUN
admet-1513	293	18	[	[	X
admet-1513	293	19	109	109	NUM
admet-1513	293	20	]	]	PUNCT
admet-1513	293	21	.	.	PUNCT
admet-1513	294	1	reports	report	NOUN
admet-1513	294	2	suggested	suggest	VERB
admet-1513	294	3	that	that	SCONJ
admet-1513	294	4	in	in	ADP
admet-1513	294	5	vitro	vitro	X
admet-1513	294	6	-	-	PUNCT
admet-1513	294	7	generated	generate	VERB
admet-1513	294	8	enteroids	enteroid	NOUN
admet-1513	294	9	replicated	replicate	VERB
admet-1513	294	10	the	the	DET
admet-1513	294	11	in	in	ADP
admet-1513	294	12	vivo	vivo	ADJ
admet-1513	294	13	tissue	tissue	NOUN
admet-1513	294	14	morphology	morphology	NOUN
admet-1513	294	15	and	and	CCONJ
admet-1513	294	16	physiology	physiology	NOUN
admet-1513	294	17	like	like	ADP
admet-1513	294	18	crypt	crypt	NOUN
admet-1513	294	19	villi	villi	NOUN
admet-1513	294	20	and	and	CCONJ
admet-1513	294	21	mucus	mucus	NOUN
admet-1513	294	22	secretion	secretion	NOUN
admet-1513	294	23	and	and	CCONJ
admet-1513	294	24	showed	show	VERB
admet-1513	294	25	functional	functional	ADJ
admet-1513	294	26	activity	activity	NOUN
admet-1513	294	27	such	such	ADJ
admet-1513	294	28	as	as	ADP
admet-1513	294	29	cyp	cyp	ADJ
admet-1513	294	30	metabolizing	metabolize	VERB
admet-1513	294	31	activity	activity	NOUN
admet-1513	294	32	for	for	ADP
admet-1513	294	33	prolonged	prolonged	ADJ
admet-1513	294	34	periods	period	NOUN
admet-1513	294	35	[	[	X
admet-1513	294	36	110	110	NUM
admet-1513	294	37	]	]	PUNCT
admet-1513	294	38	.	.	PUNCT
admet-1513	295	1	they	they	PRON
admet-1513	295	2	are	be	AUX
admet-1513	295	3	also	also	ADV
admet-1513	295	4	characterized	characterize	VERB
admet-1513	295	5	by	by	ADP
admet-1513	295	6	a	a	DET
admet-1513	295	7	central	central	ADJ
admet-1513	295	8	hollow	hollow	ADJ
admet-1513	295	9	region	region	NOUN
admet-1513	295	10	containing	contain	VERB
admet-1513	295	11	differentiated	differentiated	ADJ
admet-1513	295	12	cells	cell	NOUN
admet-1513	295	13	like	like	ADP
admet-1513	295	14	goblet	goblet	NOUN
admet-1513	295	15	cells	cell	NOUN
admet-1513	295	16	,	,	PUNCT
admet-1513	295	17	enteroendocrine	enteroendocrine	ADJ
admet-1513	295	18	cells	cell	NOUN
admet-1513	295	19	,	,	PUNCT
admet-1513	295	20	and	and	CCONJ
admet-1513	295	21	enterocytes	enterocyte	NOUN
admet-1513	295	22	,	,	PUNCT
admet-1513	295	23	which	which	PRON
admet-1513	295	24	are	be	AUX
admet-1513	295	25	extruded	extrude	VERB
admet-1513	295	26	into	into	ADP
admet-1513	295	27	the	the	DET
admet-1513	295	28	lumen	luman	NOUN
admet-1513	295	29	forming	form	VERB
admet-1513	295	30	villiand	villiand	ADJ
admet-1513	295	31	microvilli	microvilli	NOUN
admet-1513	295	32	-	-	PUNCT
admet-1513	295	33	like	like	ADJ
admet-1513	295	34	structures	structure	NOUN
admet-1513	295	35	and	and	CCONJ
admet-1513	295	36	a	a	DET
admet-1513	295	37	crypt	crypt	NOUN
admet-1513	295	38	base	base	NOUN
admet-1513	295	39	where	where	SCONJ
admet-1513	295	40	differentiated	differentiated	ADJ
admet-1513	295	41	iscs	isc	NOUN
admet-1513	295	42	and	and	CCONJ
admet-1513	295	43	paneth	paneth	PROPN
admet-1513	295	44	cells	cell	NOUN
admet-1513	295	45	reside	reside	VERB
admet-1513	295	46	.	.	PUNCT
admet-1513	296	1	typically	typically	ADV
admet-1513	296	2	,	,	PUNCT
admet-1513	296	3	enteroids	enteroid	NOUN
admet-1513	296	4	are	be	AUX
admet-1513	296	5	generated	generate	VERB
admet-1513	296	6	either	either	CCONJ
admet-1513	296	7	from	from	ADP
admet-1513	296	8	primary	primary	ADJ
admet-1513	296	9	tissues	tissue	NOUN
admet-1513	296	10	,	,	PUNCT
admet-1513	296	11	such	such	ADJ
admet-1513	296	12	as	as	ADP
admet-1513	296	13	isolated	isolated	ADJ
admet-1513	296	14	intestinal	intestinal	ADJ
admet-1513	296	15	crypts	crypt	NOUN
admet-1513	296	16	or	or	CCONJ
admet-1513	296	17	a	a	DET
admet-1513	296	18	single	single	ADJ
admet-1513	296	19	isc	isc	NOUN
admet-1513	296	20	expressing	express	VERB
admet-1513	296	21	the	the	DET
admet-1513	296	22	lgr5	lgr5	NOUN
admet-1513	296	23	marker	marker	NOUN
admet-1513	296	24	[	[	X
admet-1513	296	25	111	111	NUM
admet-1513	296	26	-	-	SYM
admet-1513	296	27	113	113	NUM
admet-1513	296	28	]	]	PUNCT
admet-1513	296	29	or	or	CCONJ
admet-1513	296	30	from	from	ADP
admet-1513	296	31	pscs	psc	NOUN
admet-1513	296	32	,	,	PUNCT
admet-1513	296	33	such	such	ADJ
admet-1513	296	34	as	as	ADP
admet-1513	296	35	hipscs	hipsc	NOUN
admet-1513	296	36	and	and	CCONJ
admet-1513	296	37	embryonic	embryonic	ADJ
admet-1513	296	38	stem	stem	NOUN
admet-1513	296	39	cells	cell	NOUN
admet-1513	296	40	(	(	PUNCT
admet-1513	296	41	esc	esc	NOUN
admet-1513	296	42	)	)	PUNCT
admet-1513	297	1	[	[	X
admet-1513	297	2	106,114	106,114	NUM
admet-1513	297	3	]	]	PUNCT
admet-1513	297	4	.	.	PUNCT
admet-1513	298	1	these	these	PRON
admet-1513	298	2	are	be	AUX
admet-1513	298	3	further	far	ADV
admet-1513	298	4	differentiated	differentiate	VERB
admet-1513	298	5	into	into	ADP
admet-1513	298	6	other	other	ADJ
admet-1513	298	7	intestinal	intestinal	ADJ
admet-1513	298	8	cell	cell	NOUN
admet-1513	298	9	types	type	NOUN
admet-1513	298	10	,	,	PUNCT
admet-1513	298	11	thus	thus	ADV
admet-1513	298	12	creating	create	VERB
admet-1513	298	13	a	a	DET
admet-1513	298	14	multilineage	multilineage	NOUN
admet-1513	298	15	culture	culture	NOUN
admet-1513	298	16	system	system	NOUN
admet-1513	298	17	[	[	X
admet-1513	298	18	115	115	NUM
admet-1513	298	19	]	]	PUNCT
admet-1513	298	20	.	.	PUNCT
admet-1513	299	1	although	although	SCONJ
admet-1513	299	2	the	the	DET
admet-1513	299	3	enteroids	enteroid	NOUN
admet-1513	299	4	have	have	VERB
admet-1513	299	5	a	a	DET
admet-1513	299	6	perfect	perfect	ADJ
admet-1513	299	7	resemblance	resemblance	NOUN
admet-1513	299	8	with	with	ADP
admet-1513	299	9	the	the	DET
admet-1513	299	10	in	in	ADP
admet-1513	299	11	vivo	vivo	ADJ
admet-1513	299	12	small	small	ADJ
admet-1513	299	13	intestines	intestine	NOUN
admet-1513	299	14	,	,	PUNCT
admet-1513	299	15	their	their	PRON
admet-1513	299	16	complex	complex	ADJ
admet-1513	299	17	morphology	morphology	NOUN
admet-1513	299	18	and	and	CCONJ
admet-1513	299	19	lack	lack	NOUN
admet-1513	299	20	of	of	ADP
admet-1513	299	21	other	other	ADJ
admet-1513	299	22	supporting	support	VERB
admet-1513	299	23	cell	cell	NOUN
admet-1513	299	24	types	type	NOUN
admet-1513	299	25	,	,	PUNCT
admet-1513	299	26	such	such	ADJ
admet-1513	299	27	as	as	ADP
admet-1513	299	28	epithelium	epithelium	NOUN
admet-1513	299	29	-	-	PUNCT
admet-1513	299	30	lined	line	VERB
admet-1513	299	31	blood	blood	NOUN
admet-1513	299	32	vessels	vessel	NOUN
admet-1513	299	33	and	and	CCONJ
admet-1513	299	34	immune	immune	ADJ
admet-1513	299	35	cells	cell	NOUN
admet-1513	299	36	,	,	PUNCT
admet-1513	299	37	may	may	AUX
admet-1513	299	38	constitute	constitute	VERB
admet-1513	299	39	significant	significant	ADJ
admet-1513	299	40	drawbacks	drawback	NOUN
admet-1513	299	41	for	for	ADP
admet-1513	299	42	studying	study	VERB
admet-1513	299	43	the	the	DET
admet-1513	299	44	drug	drug	NOUN
admet-1513	299	45	transport	transport	NOUN
admet-1513	299	46	,	,	PUNCT
admet-1513	299	47	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	299	48	analysis	analysis	NOUN
admet-1513	299	49	and	and	CCONJ
admet-1513	299	50	disease	disease	NOUN
admet-1513	299	51	modelling	model	VERB
admet-1513	299	52	[	[	X
admet-1513	299	53	116	116	NUM
admet-1513	299	54	]	]	PUNCT
admet-1513	299	55	.	.	PUNCT
admet-1513	300	1	their	their	PRON
admet-1513	300	2	closed	closed	ADJ
admet-1513	300	3	lumens	lumen	NOUN
admet-1513	300	4	limit	limit	NOUN
admet-1513	300	5	access	access	NOUN
admet-1513	300	6	to	to	ADP
admet-1513	300	7	the	the	DET
admet-1513	300	8	apical	apical	ADJ
admet-1513	300	9	surface	surface	NOUN
admet-1513	300	10	,	,	PUNCT
admet-1513	300	11	hindering	hinder	VERB
admet-1513	300	12	the	the	DET
admet-1513	300	13	drug	drug	NOUN
admet-1513	300	14	absorption	absorption	NOUN
admet-1513	300	15	studies	study	NOUN
admet-1513	300	16	and	and	CCONJ
admet-1513	300	17	coculturing	coculture	VERB
admet-1513	300	18	of	of	ADP
admet-1513	300	19	pathogens	pathogen	NOUN
admet-1513	300	20	[	[	X
admet-1513	300	21	116,117	116,117	NUM
admet-1513	300	22	]	]	PUNCT
admet-1513	300	23	.	.	PUNCT
admet-1513	301	1	it	it	PRON
admet-1513	301	2	is	be	AUX
admet-1513	301	3	challenging	challenge	VERB
admet-1513	301	4	to	to	PART
admet-1513	301	5	perform	perform	VERB
admet-1513	301	6	quantitative	quantitative	ADJ
admet-1513	301	7	assessments	assessment	NOUN
admet-1513	301	8	such	such	ADJ
admet-1513	301	9	as	as	ADP
admet-1513	301	10	paracellular	paracellular	ADJ
admet-1513	301	11	and	and	CCONJ
admet-1513	301	12	transcellular	transcellular	ADJ
admet-1513	301	13	assays	assay	NOUN
admet-1513	301	14	without	without	ADP
admet-1513	301	15	changing	change	VERB
admet-1513	301	16	the	the	DET
admet-1513	301	17	organoid	organoid	NOUN
admet-1513	301	18	structure	structure	NOUN
admet-1513	301	19	[	[	X
admet-1513	301	20	118	118	NUM
admet-1513	301	21	]	]	PUNCT
admet-1513	301	22	.	.	PUNCT
admet-1513	302	1	the	the	DET
admet-1513	302	2	microinjection	microinjection	NOUN
admet-1513	302	3	technique	technique	NOUN
admet-1513	302	4	was	be	AUX
admet-1513	302	5	found	find	VERB
admet-1513	302	6	to	to	PART
admet-1513	302	7	be	be	AUX
admet-1513	302	8	promising	promise	VERB
admet-1513	302	9	for	for	ADP
admet-1513	302	10	accessing	access	VERB
admet-1513	302	11	the	the	DET
admet-1513	302	12	luminal	luminal	ADJ
admet-1513	302	13	side	side	NOUN
admet-1513	302	14	for	for	ADP
admet-1513	302	15	studying	study	VERB
admet-1513	302	16	the	the	DET
admet-1513	302	17	absorption	absorption	NOUN
admet-1513	302	18	of	of	ADP
admet-1513	302	19	drugs	drug	NOUN
admet-1513	302	20	,	,	PUNCT
admet-1513	302	21	food	food	NOUN
admet-1513	302	22	and	and	CCONJ
admet-1513	302	23	toxins	toxin	NOUN
admet-1513	302	24	across	across	ADP
admet-1513	302	25	the	the	DET
admet-1513	302	26	intestinal	intestinal	ADJ
admet-1513	302	27	epithelium	epithelium	NOUN
admet-1513	303	1	[	[	X
admet-1513	303	2	116	116	NUM
admet-1513	303	3	]	]	PUNCT
admet-1513	303	4	.	.	PUNCT
admet-1513	304	1	several	several	ADJ
admet-1513	304	2	reports	report	NOUN
admet-1513	304	3	are	be	AUX
admet-1513	304	4	available	available	ADJ
admet-1513	304	5	that	that	SCONJ
admet-1513	304	6	use	use	VERB
admet-1513	304	7	microinjection	microinjection	NOUN
admet-1513	304	8	techniques	technique	NOUN
admet-1513	304	9	for	for	ADP
admet-1513	304	10	studying	study	VERB
admet-1513	304	11	the	the	DET
admet-1513	304	12	absorption	absorption	NOUN
admet-1513	304	13	of	of	ADP
admet-1513	304	14	different	different	ADJ
admet-1513	304	15	molecules	molecule	NOUN
admet-1513	304	16	,	,	PUNCT
admet-1513	304	17	such	such	ADJ
admet-1513	304	18	as	as	ADP
admet-1513	304	19	monosaccharides	monosaccharide	NOUN
admet-1513	304	20	and	and	CCONJ
admet-1513	304	21	peptides	peptide	NOUN
admet-1513	304	22	,	,	PUNCT
admet-1513	304	23	with	with	ADP
admet-1513	304	24	the	the	DET
admet-1513	304	25	help	help	NOUN
admet-1513	304	26	of	of	ADP
admet-1513	304	27	fluorescent	fluorescent	ADJ
admet-1513	304	28	tracers	tracer	NOUN
admet-1513	304	29	[	[	X
admet-1513	304	30	119,120	119,120	NUM
admet-1513	304	31	]	]	PUNCT
admet-1513	304	32	.	.	PUNCT
admet-1513	305	1	however	however	ADV
admet-1513	305	2	,	,	PUNCT
admet-1513	305	3	the	the	DET
admet-1513	305	4	application	application	NOUN
admet-1513	305	5	of	of	ADP
admet-1513	305	6	this	this	DET
admet-1513	305	7	technique	technique	NOUN
admet-1513	305	8	is	be	AUX
admet-1513	305	9	limited	limit	VERB
admet-1513	305	10	due	due	ADP
admet-1513	305	11	to	to	ADP
admet-1513	305	12	expensive	expensive	ADJ
admet-1513	305	13	fluorophores	fluorophore	NOUN
admet-1513	305	14	,	,	PUNCT
admet-1513	305	15	less	less	ADJ
admet-1513	305	16	reproducibility	reproducibility	NOUN
admet-1513	305	17	and	and	CCONJ
admet-1513	305	18	irreversible	irreversible	ADJ
admet-1513	305	19	damage	damage	NOUN
admet-1513	305	20	caused	cause	VERB
admet-1513	305	21	during	during	ADP
admet-1513	305	22	microinjection	microinjection	NOUN
admet-1513	305	23	[	[	X
admet-1513	305	24	120,121	120,121	NUM
admet-1513	305	25	]	]	PUNCT
admet-1513	305	26	.	.	PUNCT
admet-1513	306	1	to	to	PART
admet-1513	306	2	overcome	overcome	VERB
admet-1513	306	3	such	such	ADJ
admet-1513	306	4	limitations	limitation	NOUN
admet-1513	306	5	,	,	PUNCT
admet-1513	306	6	researchers	researcher	NOUN
admet-1513	306	7	tried	try	VERB
admet-1513	306	8	to	to	PART
admet-1513	306	9	adopt	adopt	VERB
admet-1513	306	10	other	other	ADJ
admet-1513	306	11	techniques	technique	NOUN
admet-1513	306	12	,	,	PUNCT
admet-1513	306	13	where	where	SCONJ
admet-1513	306	14	the	the	DET
admet-1513	306	15	3d	3d	PROPN
admet-1513	306	16	organoids	organoid	NOUN
admet-1513	306	17	are	be	AUX
admet-1513	306	18	mechanically	mechanically	ADV
admet-1513	306	19	disrupted	disrupt	VERB
admet-1513	306	20	and	and	CCONJ
admet-1513	306	21	then	then	ADV
admet-1513	306	22	replated	replate	VERB
admet-1513	306	23	onto	onto	ADP
admet-1513	306	24	2d	2d	NUM
admet-1513	306	25	plates	plate	NOUN
admet-1513	306	26	for	for	ADP
admet-1513	306	27	recovery	recovery	NOUN
admet-1513	306	28	,	,	PUNCT
admet-1513	306	29	thus	thus	ADV
admet-1513	306	30	allowing	allow	VERB
admet-1513	306	31	the	the	DET
admet-1513	306	32	utilization	utilization	NOUN
admet-1513	306	33	of	of	ADP
admet-1513	306	34	both	both	CCONJ
admet-1513	306	35	apical	apical	ADJ
admet-1513	306	36	and	and	CCONJ
admet-1513	306	37	basolateral	basolateral	ADJ
admet-1513	306	38	sides	side	NOUN
admet-1513	306	39	[	[	X
admet-1513	306	40	122	122	NUM
admet-1513	306	41	]	]	PUNCT
admet-1513	306	42	.	.	PUNCT
admet-1513	307	1	the	the	DET
admet-1513	307	2	organoids	organoid	NOUN
admet-1513	307	3	that	that	PRON
admet-1513	307	4	are	be	AUX
admet-1513	307	5	generated	generate	VERB
admet-1513	307	6	from	from	ADP
admet-1513	307	7	hipscs	hipsc	NOUN
admet-1513	307	8	were	be	AUX
admet-1513	307	9	mechanically	mechanically	ADV
admet-1513	307	10	separated	separate	VERB
admet-1513	307	11	and	and	CCONJ
admet-1513	307	12	filtered	filter	VERB
admet-1513	307	13	by	by	ADP
admet-1513	307	14	the	the	DET
admet-1513	307	15	mesenchymal	mesenchymal	NOUN
admet-1513	307	16	cells	cell	NOUN
admet-1513	307	17	to	to	PART
admet-1513	307	18	avoid	avoid	VERB
admet-1513	307	19	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	307	20	function	function	NOUN
admet-1513	307	21	.	.	PUNCT
admet-1513	308	1	the	the	DET
admet-1513	308	2	purified	purified	ADJ
admet-1513	308	3	cells	cell	NOUN
admet-1513	308	4	were	be	AUX
admet-1513	308	5	replated	replate	VERB
admet-1513	308	6	and	and	CCONJ
admet-1513	308	7	grown	grow	VERB
admet-1513	308	8	as	as	ADP
admet-1513	308	9	a	a	DET
admet-1513	308	10	hipsc	hipsc	ADJ
admet-1513	308	11	-	-	PUNCT
admet-1513	308	12	iec	iec	NOUN
admet-1513	308	13	monolayer	monolayer	NOUN
admet-1513	308	14	.	.	PUNCT
admet-1513	309	1	this	this	DET
admet-1513	309	2	hipsc	hipsc	ADJ
admet-1513	309	3	-	-	PUNCT
admet-1513	309	4	iec	iec	NOUN
admet-1513	309	5	monolayer	monolayer	NOUN
admet-1513	309	6	was	be	AUX
admet-1513	309	7	further	far	ADV
admet-1513	309	8	used	use	VERB
admet-1513	309	9	for	for	ADP
admet-1513	309	10	screening	screen	VERB
admet-1513	309	11	metabolites	metabolite	NOUN
admet-1513	309	12	that	that	PRON
admet-1513	309	13	have	have	VERB
admet-1513	309	14	specificity	specificity	NOUN
admet-1513	309	15	for	for	ADP
admet-1513	309	16	cyp3a	cyp3a	NOUN
admet-1513	309	17	,	,	PUNCT
admet-1513	309	18	which	which	PRON
admet-1513	309	19	can	can	AUX
admet-1513	309	20	not	not	PART
admet-1513	309	21	be	be	AUX
admet-1513	309	22	reproduced	reproduce	VERB
admet-1513	309	23	by	by	ADP
admet-1513	309	24	conventional	conventional	ADJ
admet-1513	309	25	2d	2d	NUM
admet-1513	309	26	models	model	NOUN
admet-1513	309	27	.	.	PUNCT
admet-1513	310	1	the	the	DET
admet-1513	310	2	model	model	NOUN
admet-1513	310	3	was	be	AUX
admet-1513	310	4	demonstrated	demonstrate	VERB
admet-1513	310	5	to	to	PART
admet-1513	310	6	be	be	AUX
admet-1513	310	7	more	more	ADV
admet-1513	310	8	reliable	reliable	ADJ
admet-1513	310	9	in	in	ADP
admet-1513	310	10	assessing	assess	VERB
admet-1513	310	11	the	the	DET
admet-1513	310	12	uptake	uptake	NOUN
admet-1513	310	13	of	of	ADP
admet-1513	310	14	other	other	ADJ
admet-1513	310	15	molecules	molecule	NOUN
admet-1513	310	16	,	,	PUNCT
admet-1513	310	17	proving	prove	VERB
admet-1513	310	18	the	the	DET
admet-1513	310	19	dependability	dependability	NOUN
admet-1513	310	20	of	of	ADP
admet-1513	310	21	organoid	organoid	NOUN
admet-1513	310	22	-	-	PUNCT
admet-1513	310	23	derived	derive	VERB
admet-1513	310	24	iec	iec	NOUN
admet-1513	310	25	monolayers	monolayer	NOUN
admet-1513	310	26	for	for	ADP
admet-1513	310	27	evaluating	evaluate	VERB
admet-1513	310	28	xenobiotics	xenobiotic	NOUN
admet-1513	310	29	absorption	absorption	NOUN
admet-1513	310	30	.	.	PUNCT
admet-1513	311	1	however	however	ADV
admet-1513	311	2	,	,	PUNCT
admet-1513	311	3	mechanical	mechanical	ADJ
admet-1513	311	4	disruption	disruption	NOUN
admet-1513	311	5	may	may	AUX
admet-1513	311	6	cause	cause	VERB
admet-1513	311	7	irreversible	irreversible	ADJ
admet-1513	311	8	damage	damage	NOUN
admet-1513	311	9	to	to	ADP
admet-1513	311	10	the	the	DET
admet-1513	311	11	stem	stem	NOUN
admet-1513	311	12	-	-	PUNCT
admet-1513	311	13	cell	cell	NOUN
admet-1513	311	14	compartment	compartment	NOUN
admet-1513	311	15	,	,	PUNCT
admet-1513	311	16	thus	thus	ADV
admet-1513	311	17	affecting	affect	VERB
admet-1513	311	18	the	the	DET
admet-1513	311	19	propagation	propagation	NOUN
admet-1513	311	20	and	and	CCONJ
admet-1513	311	21	differentiation	differentiation	NOUN
admet-1513	311	22	of	of	ADP
admet-1513	311	23	the	the	DET
admet-1513	311	24	organoid	organoid	NOUN
admet-1513	311	25	.	.	PUNCT
admet-1513	312	1	the	the	DET
admet-1513	312	2	authors	author	NOUN
admet-1513	312	3	also	also	ADV
admet-1513	312	4	stated	state	VERB
admet-1513	312	5	much	much	ADJ
admet-1513	312	6	refinement	refinement	NOUN
admet-1513	312	7	in	in	ADP
admet-1513	312	8	this	this	DET
admet-1513	312	9	technique	technique	NOUN
admet-1513	312	10	is	be	AUX
admet-1513	312	11	required	require	VERB
admet-1513	312	12	to	to	PART
admet-1513	312	13	ensure	ensure	VERB
admet-1513	312	14	reproducibility	reproducibility	NOUN
admet-1513	312	15	and	and	CCONJ
admet-1513	312	16	replicability	replicability	NOUN
admet-1513	312	17	to	to	PART
admet-1513	312	18	perform	perform	VERB
admet-1513	312	19	thigh	thigh	NOUN
admet-1513	312	20	throughput	throughput	NOUN
admet-1513	312	21	assays	assay	NOUN
admet-1513	312	22	.	.	PUNCT
admet-1513	313	1	thus	thus	ADV
admet-1513	313	2	enteroids	enteroid	NOUN
admet-1513	313	3	may	may	AUX
admet-1513	313	4	not	not	PART
admet-1513	313	5	be	be	AUX
admet-1513	313	6	the	the	DET
admet-1513	313	7	best	good	ADJ
admet-1513	313	8	tool	tool	NOUN
admet-1513	313	9	for	for	ADP
admet-1513	313	10	evaluating	evaluate	VERB
admet-1513	313	11	the	the	DET
admet-1513	313	12	drug	drug	NOUN
admet-1513	313	13	absorption	absorption	NOUN
admet-1513	313	14	processes	process	NOUN
admet-1513	313	15	through	through	ADP
admet-1513	313	16	the	the	DET
admet-1513	313	17	intestinal	intestinal	ADJ
admet-1513	313	18	barrier	barrier	NOUN
admet-1513	313	19	.	.	PUNCT
admet-1513	314	1	further	far	ADV
admet-1513	314	2	,	,	PUNCT
admet-1513	314	3	the	the	DET
admet-1513	314	4	lack	lack	NOUN
admet-1513	314	5	of	of	ADP
admet-1513	314	6	a	a	DET
admet-1513	314	7	vascular	vascular	ADJ
admet-1513	314	8	mimicking	mimic	VERB
admet-1513	314	9	system	system	NOUN
admet-1513	314	10	,	,	PUNCT
admet-1513	314	11	that	that	PRON
admet-1513	314	12	helps	help	VERB
admet-1513	314	13	in	in	ADP
admet-1513	314	14	the	the	DET
admet-1513	314	15	transport	transport	NOUN
admet-1513	314	16	of	of	ADP
admet-1513	314	17	nutrients	nutrient	NOUN
admet-1513	314	18	and	and	CCONJ
admet-1513	314	19	waste	waste	NOUN
admet-1513	314	20	also	also	ADV
admet-1513	314	21	impacts	impact	VERB
admet-1513	314	22	the	the	DET
admet-1513	314	23	reliability	reliability	NOUN
admet-1513	314	24	of	of	ADP
admet-1513	314	25	this	this	DET
admet-1513	314	26	model	model	NOUN
admet-1513	314	27	.	.	PUNCT
admet-1513	315	1	to	to	PART
admet-1513	315	2	overcome	overcome	VERB
admet-1513	315	3	this	this	PRON
admet-1513	315	4	,	,	PUNCT
admet-1513	315	5	alternative	alternative	ADJ
admet-1513	315	6	strategies	strategy	NOUN
admet-1513	315	7	like	like	ADP
admet-1513	315	8	integrating	integrate	VERB
admet-1513	315	9	these	these	DET
admet-1513	315	10	enteroids	enteroid	NOUN
admet-1513	315	11	with	with	ADP
admet-1513	315	12	dynamic	dynamic	ADJ
admet-1513	315	13	flow	flow	NOUN
admet-1513	315	14	systems	system	NOUN
admet-1513	315	15	like	like	ADP
admet-1513	315	16	bioreactors	bioreactor	NOUN
admet-1513	315	17	and	and	CCONJ
admet-1513	315	18	miniature	miniature	ADJ
admet-1513	315	19	flow	flow	NOUN
admet-1513	315	20	chips	chip	NOUN
admet-1513	315	21	where	where	SCONJ
admet-1513	315	22	precise	precise	ADJ
admet-1513	315	23	physical	physical	ADJ
admet-1513	315	24	,	,	PUNCT
admet-1513	315	25	biological	biological	ADJ
admet-1513	315	26	and	and	CCONJ
admet-1513	315	27	chemical	chemical	NOUN
admet-1513	315	28	conditions	condition	NOUN
admet-1513	315	29	might	might	AUX
admet-1513	315	30	be	be	AUX
admet-1513	315	31	imposed	impose	VERB
admet-1513	315	32	[	[	PUNCT
admet-1513	315	33	123	123	NUM
admet-1513	315	34	-	-	SYM
admet-1513	315	35	125	125	NUM
admet-1513	315	36	]	]	PUNCT
admet-1513	315	37	.	.	PUNCT
admet-1513	316	1	in	in	ADP
admet-1513	316	2	this	this	PRON
admet-1513	316	3	,	,	PUNCT
admet-1513	316	4	hipsc	hipsc	ADJ
admet-1513	316	5	and	and	CCONJ
admet-1513	316	6	tissue	tissue	NOUN
admet-1513	316	7	engineering	engineering	NOUN
admet-1513	316	8	techniques	technique	NOUN
admet-1513	316	9	generated	generate	VERB
admet-1513	316	10	tubeshaped	tubeshape	VERB
admet-1513	316	11	epithelia	epithelium	NOUN
admet-1513	316	12	,	,	PUNCT
admet-1513	316	13	which	which	PRON
admet-1513	316	14	they	they	PRON
admet-1513	316	15	named	name	VERB
admet-1513	316	16	mini	mini	NOUN
admet-1513	316	17	-	-	NOUN
admet-1513	316	18	intestine	intestine	ADJ
admet-1513	316	19	containing	contain	VERB
admet-1513	316	20	cryptand	cryptand	ADJ
admet-1513	316	21	villi	villi	NOUN
admet-1513	316	22	-	-	PUNCT
admet-1513	316	23	like	like	ADJ
admet-1513	316	24	domains	domain	NOUN
admet-1513	316	25	with	with	ADP
admet-1513	316	26	an	an	DET
admet-1513	316	27	accessible	accessible	ADJ
admet-1513	316	28	lumen	luman	NOUN
admet-1513	316	29	.	.	PUNCT
admet-1513	317	1	the	the	DET
admet-1513	317	2	structure	structure	NOUN
admet-1513	317	3	has	have	VERB
admet-1513	317	4	a	a	DET
admet-1513	317	5	much	much	ADV
admet-1513	317	6	similar	similar	ADJ
admet-1513	317	7	spatial	spatial	ADJ
admet-1513	317	8	arrangement	arrangement	NOUN
admet-1513	317	9	as	as	ADP
admet-1513	317	10	that	that	PRON
admet-1513	317	11	of	of	ADP
admet-1513	317	12	in	in	ADP
admet-1513	317	13	vivo	vivo	NOUN
admet-1513	317	14	.	.	PUNCT
admet-1513	318	1	when	when	SCONJ
admet-1513	318	2	this	this	DET
admet-1513	318	3	tube	tube	NOUN
admet-1513	318	4	structure	structure	NOUN
admet-1513	318	5	was	be	AUX
admet-1513	318	6	connected	connect	VERB
admet-1513	318	7	to	to	ADP
admet-1513	318	8	an	an	DET
admet-1513	318	9	external	external	ADJ
admet-1513	318	10	pump	pump	NOUN
admet-1513	318	11	,	,	PUNCT
admet-1513	318	12	the	the	DET
admet-1513	318	13	miniguts	minigut	NOUN
admet-1513	318	14	were	be	AUX
admet-1513	318	15	penetrable	penetrable	ADJ
admet-1513	318	16	,	,	PUNCT
admet-1513	318	17	which	which	PRON
admet-1513	318	18	allowed	allow	VERB
admet-1513	318	19	constant	constant	ADJ
admet-1513	318	20	elimination	elimination	NOUN
admet-1513	318	21	of	of	ADP
admet-1513	318	22	dead	dead	ADJ
admet-1513	318	23	cells	cell	NOUN
admet-1513	318	24	,	,	PUNCT
admet-1513	318	25	thus	thus	ADV
admet-1513	318	26	prolonging	prolong	VERB
admet-1513	318	27	its	its	PRON
admet-1513	318	28	life	life	NOUN
admet-1513	318	29	span	span	NOUN
admet-1513	318	30	for	for	ADP
admet-1513	318	31	several	several	ADJ
admet-1513	318	32	weeks	week	NOUN
admet-1513	318	33	.	.	PUNCT
admet-1513	319	1	these	these	DET
admet-1513	319	2	structures	structure	NOUN
admet-1513	319	3	also	also	ADV
admet-1513	319	4	helped	help	VERB
admet-1513	319	5	in	in	ADP
admet-1513	319	6	the	the	DET
admet-1513	319	7	co	co	NOUN
admet-1513	319	8	-	-	NOUN
admet-1513	319	9	culturing	culturing	NOUN
admet-1513	319	10	of	of	ADP
admet-1513	319	11	microorganisms	microorganism	NOUN
admet-1513	319	12	for	for	ADP
admet-1513	319	13	modelling	model	VERB
admet-1513	319	14	host	host	NOUN
admet-1513	319	15	-	-	PUNCT
admet-1513	319	16	microorganism	microorganism	NOUN
admet-1513	319	17	interactions	interaction	NOUN
admet-1513	319	18	.	.	PUNCT
admet-1513	320	1	the	the	DET
admet-1513	320	2	mini	mini	NOUN
admet-1513	320	3	-	-	NOUN
admet-1513	320	4	intestines	intestine	NOUN
admet-1513	320	5	have	have	VERB
admet-1513	320	6	all	all	DET
admet-1513	320	7	the	the	DET
admet-1513	320	8	cell	cell	NOUN
admet-1513	320	9	types	type	NOUN
admet-1513	320	10	often	often	ADV
admet-1513	320	11	found	find	VERB
admet-1513	320	12	in	in	ADP
admet-1513	320	13	conventional	conventional	ADJ
admet-1513	320	14	organoids	organoid	NOUN
admet-1513	320	15	.	.	PUNCT
admet-1513	321	1	these	these	DET
admet-1513	321	2	structures	structure	NOUN
admet-1513	321	3	preserve	preserve	VERB
admet-1513	321	4	important	important	ADJ
admet-1513	321	5	physiological	physiological	ADJ
admet-1513	321	6	characteristics	characteristic	NOUN
admet-1513	321	7	of	of	ADP
admet-1513	321	8	the	the	DET
admet-1513	321	9	intestines	intestine	NOUN
admet-1513	321	10	along	along	ADP
admet-1513	321	11	with	with	ADP
admet-1513	321	12	regeneration	regeneration	NOUN
admet-1513	321	13	potential	potential	NOUN
admet-1513	321	14	.	.	PUNCT
admet-1513	322	1	in	in	ADP
admet-1513	322	2	addition	addition	NOUN
admet-1513	322	3	,	,	PUNCT
admet-1513	322	4	the	the	DET
admet-1513	322	5	researchers	researcher	NOUN
admet-1513	322	6	stated	state	VERB
admet-1513	322	7	that	that	SCONJ
admet-1513	322	8	the	the	DET
admet-1513	322	9	concept	concept	NOUN
admet-1513	322	10	of	of	ADP
admet-1513	322	11	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	322	12	venkatesh	venkatesh	PROPN
admet-1513	322	13	chunduri	chunduri	PROPN
admet-1513	322	14	and	and	CCONJ
admet-1513	322	15	srinivas	srinivas	PROPN
admet-1513	322	16	maddi	maddi	PROPN
admet-1513	322	17	admet	admet	PROPN
admet-1513	322	18	&	&	CCONJ
admet-1513	322	19	dmpk	dmpk	PROPN
admet-1513	322	20	11(1	11(1	NUM
admet-1513	322	21	)	)	PUNCT
admet-1513	322	22	(	(	PUNCT
admet-1513	322	23	2023	2023	NUM
admet-1513	322	24	)	)	PUNCT
admet-1513	322	25	1	1	NUM
admet-1513	322	26	-	-	SYM
admet-1513	322	27	32	32	NUM
admet-1513	322	28	12	12	NUM
admet-1513	322	29	generating	generate	VERB
admet-1513	322	30	the	the	DET
admet-1513	322	31	functional	functional	ADJ
admet-1513	322	32	organ	organ	NOUN
admet-1513	322	33	-	-	PUNCT
admet-1513	322	34	on	on	ADP
admet-1513	322	35	-	-	PUNCT
admet-1513	322	36	a	a	DET
admet-1513	322	37	-	-	PUNCT
admet-1513	322	38	chip	chip	NOUN
admet-1513	322	39	models	model	NOUN
admet-1513	322	40	attains	attain	VERB
admet-1513	322	41	physiologically	physiologically	ADV
admet-1513	322	42	relevant	relevant	ADJ
admet-1513	322	43	organoid	organoid	NOUN
admet-1513	322	44	shapes	shape	NOUN
admet-1513	322	45	,	,	PUNCT
admet-1513	322	46	size	size	NOUN
admet-1513	322	47	and	and	CCONJ
admet-1513	322	48	function	function	NOUN
admet-1513	322	49	along	along	ADP
admet-1513	322	50	with	with	ADP
admet-1513	322	51	very	very	ADV
admet-1513	322	52	broad	broad	ADJ
admet-1513	322	53	application	application	NOUN
admet-1513	322	54	in	in	ADP
admet-1513	322	55	drug	drug	NOUN
admet-1513	322	56	discovery	discovery	NOUN
admet-1513	322	57	.	.	PUNCT
admet-1513	323	1	pérez	pérez	NOUN
admet-1513	323	2	-	-	PUNCT
admet-1513	323	3	gonzález	gonzález	PROPN
admet-1513	323	4	and	and	CCONJ
admet-1513	323	5	colleagues[126	colleagues[126	PROPN
admet-1513	323	6	]	]	PUNCT
admet-1513	323	7	developed	develop	VERB
admet-1513	323	8	mechanically	mechanically	ADV
admet-1513	323	9	accessible	accessible	ADJ
admet-1513	323	10	intestinal	intestinal	ADJ
admet-1513	323	11	organoids	organoid	NOUN
admet-1513	323	12	on	on	ADP
admet-1513	323	13	the	the	DET
admet-1513	323	14	hydrogels	hydrogel	NOUN
admet-1513	323	15	.	.	PUNCT
admet-1513	324	1	they	they	PRON
admet-1513	324	2	observed	observe	VERB
admet-1513	324	3	lapse	lapse	NOUN
admet-1513	324	4	force	force	NOUN
admet-1513	324	5	mapping	mapping	NOUN
admet-1513	324	6	with	with	ADP
admet-1513	324	7	subcellular	subcellular	ADJ
admet-1513	324	8	resolution	resolution	NOUN
admet-1513	324	9	on	on	ADP
admet-1513	324	10	their	their	PRON
admet-1513	324	11	organoid	organoid	NOUN
admet-1513	324	12	monolayer	monolayer	NOUN
admet-1513	324	13	,	,	PUNCT
admet-1513	324	14	which	which	PRON
admet-1513	324	15	provided	provide	VERB
admet-1513	324	16	several	several	ADJ
admet-1513	324	17	advantages	advantage	NOUN
admet-1513	324	18	over	over	ADP
admet-1513	324	19	conventional	conventional	ADJ
admet-1513	324	20	organoids	organoid	NOUN
admet-1513	324	21	that	that	PRON
admet-1513	324	22	are	be	AUX
admet-1513	324	23	generated	generate	VERB
admet-1513	324	24	over	over	ADP
admet-1513	324	25	an	an	DET
admet-1513	324	26	extracellular	extracellular	ADJ
admet-1513	324	27	matrix	matrix	NOUN
admet-1513	324	28	.	.	PUNCT
admet-1513	325	1	these	these	PRON
admet-1513	325	2	include	include	VERB
admet-1513	325	3	easy	easy	ADJ
admet-1513	325	4	optical	optical	ADJ
admet-1513	325	5	access	access	NOUN
admet-1513	325	6	,	,	PUNCT
admet-1513	325	7	flexible	flexible	ADJ
admet-1513	325	8	mechanical	mechanical	ADJ
admet-1513	325	9	environment	environment	NOUN
admet-1513	325	10	management	management	NOUN
admet-1513	325	11	,	,	PUNCT
admet-1513	325	12	and	and	CCONJ
admet-1513	325	13	an	an	DET
admet-1513	325	14	open	open	ADJ
admet-1513	325	15	lumen	luman	NOUN
admet-1513	325	16	that	that	PRON
admet-1513	325	17	more	more	ADV
admet-1513	325	18	closely	closely	ADV
admet-1513	325	19	resembles	resemble	VERB
admet-1513	325	20	the	the	DET
admet-1513	325	21	open	open	ADJ
admet-1513	325	22	-	-	PUNCT
admet-1513	325	23	tube	tube	NOUN
admet-1513	325	24	shape	shape	NOUN
admet-1513	325	25	of	of	ADP
admet-1513	325	26	the	the	DET
admet-1513	325	27	intestine	intestine	NOUN
admet-1513	325	28	and	and	CCONJ
admet-1513	325	29	eliminates	eliminate	VERB
admet-1513	325	30	the	the	DET
admet-1513	325	31	accumulation	accumulation	NOUN
admet-1513	325	32	of	of	ADP
admet-1513	325	33	dead	dead	ADJ
admet-1513	325	34	cells	cell	NOUN
admet-1513	325	35	.	.	PUNCT
admet-1513	326	1	in	in	ADP
admet-1513	326	2	addition	addition	NOUN
admet-1513	326	3	,	,	PUNCT
admet-1513	326	4	these	these	DET
admet-1513	326	5	organoids	organoid	NOUN
admet-1513	326	6	displayed	display	VERB
admet-1513	326	7	a	a	DET
admet-1513	326	8	collective	collective	ADJ
admet-1513	326	9	migratory	migratory	NOUN
admet-1513	326	10	pattern	pattern	NOUN
admet-1513	326	11	from	from	ADP
admet-1513	326	12	the	the	DET
admet-1513	326	13	crypt	crypt	NOUN
admet-1513	326	14	to	to	ADP
admet-1513	326	15	the	the	DET
admet-1513	326	16	villus	villus	NOUN
admet-1513	326	17	that	that	PRON
admet-1513	326	18	is	be	AUX
admet-1513	326	19	not	not	PART
admet-1513	326	20	often	often	ADV
admet-1513	326	21	observed	observe	VERB
admet-1513	326	22	in	in	ADP
admet-1513	326	23	conventional	conventional	ADJ
admet-1513	326	24	organoids	organoid	NOUN
admet-1513	326	25	.	.	PUNCT
admet-1513	327	1	however	however	ADV
admet-1513	327	2	,	,	PUNCT
admet-1513	327	3	their	their	PRON
admet-1513	327	4	models	model	NOUN
admet-1513	327	5	have	have	VERB
admet-1513	327	6	shorter	short	ADJ
admet-1513	327	7	transit	transit	NOUN
admet-1513	327	8	amplifying	amplify	VERB
admet-1513	327	9	zone	zone	NOUN
admet-1513	327	10	,	,	PUNCT
admet-1513	327	11	irregular	irregular	ADJ
admet-1513	327	12	geometry	geometry	NOUN
admet-1513	327	13	of	of	ADP
admet-1513	327	14	the	the	DET
admet-1513	327	15	villus	villus	ADJ
admet-1513	327	16	,	,	PUNCT
admet-1513	327	17	thinner	thin	ADJ
admet-1513	327	18	cells	cell	NOUN
admet-1513	327	19	in	in	ADP
admet-1513	327	20	the	the	DET
admet-1513	327	21	villi	villi	NOUN
admet-1513	327	22	and	and	CCONJ
admet-1513	327	23	lack	lack	NOUN
admet-1513	327	24	of	of	ADP
admet-1513	327	25	a	a	DET
admet-1513	327	26	well	well	ADV
admet-1513	327	27	-	-	PUNCT
admet-1513	327	28	developed	develop	VERB
admet-1513	327	29	brush	brush	NOUN
admet-1513	327	30	-	-	PUNCT
admet-1513	327	31	boarder	boarder	NOUN
admet-1513	327	32	compared	compare	VERB
admet-1513	327	33	to	to	ADP
admet-1513	327	34	in	in	ADP
admet-1513	327	35	vivo	vivo	NOUN
admet-1513	327	36	.	.	PUNCT
admet-1513	328	1	similarly	similarly	ADV
admet-1513	328	2	,	,	PUNCT
admet-1513	328	3	yang	yang	PROPN
admet-1513	328	4	and	and	CCONJ
admet-1513	328	5	colleagues[127	colleagues[127	PROPN
admet-1513	328	6	]	]	PUNCT
admet-1513	328	7	also	also	ADV
admet-1513	328	8	developed	develop	VERB
admet-1513	328	9	intestinal	intestinal	ADJ
admet-1513	328	10	organoids	organoid	NOUN
admet-1513	328	11	from	from	ADP
admet-1513	328	12	isolated	isolated	ADJ
admet-1513	328	13	crypts	crypt	NOUN
admet-1513	328	14	of	of	ADP
admet-1513	328	15	the	the	DET
admet-1513	328	16	murine	murine	ADJ
admet-1513	328	17	small	small	ADJ
admet-1513	328	18	intestines	intestine	NOUN
admet-1513	328	19	.	.	PUNCT
admet-1513	329	1	they	they	PRON
admet-1513	329	2	demonstrated	demonstrate	VERB
admet-1513	329	3	the	the	DET
admet-1513	329	4	crypt	crypt	NOUN
admet-1513	329	5	morphogenesis	morphogenesis	NOUN
admet-1513	329	6	in	in	ADP
admet-1513	329	7	intestinal	intestinal	ADJ
admet-1513	329	8	organoids	organoid	NOUN
admet-1513	329	9	by	by	ADP
admet-1513	329	10	increasing	increase	VERB
admet-1513	329	11	the	the	DET
admet-1513	329	12	cell	cell	NOUN
admet-1513	329	13	volume	volume	NOUN
admet-1513	329	14	of	of	ADP
admet-1513	329	15	differentiated	differentiated	ADJ
admet-1513	329	16	enterocytes	enterocyte	NOUN
admet-1513	329	17	resulting	result	VERB
admet-1513	329	18	in	in	ADP
admet-1513	329	19	a	a	DET
admet-1513	329	20	pressurized	pressurized	ADJ
admet-1513	329	21	lumen	luman	NOUN
admet-1513	329	22	.	.	PUNCT
admet-1513	330	1	nevertheless	nevertheless	ADV
admet-1513	330	2	,	,	PUNCT
admet-1513	330	3	the	the	DET
admet-1513	330	4	generation	generation	NOUN
admet-1513	330	5	and	and	CCONJ
admet-1513	330	6	maintenance	maintenance	NOUN
admet-1513	330	7	of	of	ADP
admet-1513	330	8	miniguts	minigut	NOUN
admet-1513	330	9	are	be	AUX
admet-1513	330	10	much	much	ADV
admet-1513	330	11	more	more	ADV
admet-1513	330	12	challenging	challenging	ADJ
admet-1513	330	13	and	and	CCONJ
admet-1513	330	14	expensive	expensive	ADJ
admet-1513	330	15	for	for	ADP
admet-1513	330	16	consideration	consideration	NOUN
admet-1513	330	17	in	in	ADP
admet-1513	330	18	pre	pre	ADJ
admet-1513	330	19	-	-	ADJ
admet-1513	330	20	clinical	clinical	ADJ
admet-1513	330	21	trials	trial	NOUN
admet-1513	330	22	.	.	PUNCT
admet-1513	331	1	even	even	ADV
admet-1513	331	2	the	the	DET
admet-1513	331	3	outcomes	outcome	NOUN
admet-1513	331	4	derived	derive	VERB
admet-1513	331	5	from	from	ADP
admet-1513	331	6	drug	drug	NOUN
admet-1513	331	7	toxicity	toxicity	NOUN
admet-1513	331	8	and	and	CCONJ
admet-1513	331	9	efficacy	efficacy	NOUN
admet-1513	331	10	studies	study	NOUN
admet-1513	331	11	using	use	VERB
admet-1513	331	12	these	these	DET
admet-1513	331	13	models	model	NOUN
admet-1513	331	14	often	often	ADV
admet-1513	331	15	lack	lack	VERB
admet-1513	331	16	reproducibility	reproducibility	NOUN
admet-1513	331	17	due	due	ADP
admet-1513	331	18	to	to	ADP
admet-1513	331	19	the	the	DET
admet-1513	331	20	intrinsic	intrinsic	ADJ
admet-1513	331	21	variability	variability	NOUN
admet-1513	331	22	of	of	ADP
admet-1513	331	23	the	the	DET
admet-1513	331	24	organoid	organoid	PROPN
admet-1513	331	25	source	source	NOUN
admet-1513	331	26	,	,	PUNCT
admet-1513	331	27	shape	shape	NOUN
admet-1513	331	28	and	and	CCONJ
admet-1513	331	29	size	size	NOUN
admet-1513	331	30	[	[	X
admet-1513	331	31	128	128	NUM
admet-1513	331	32	]	]	PUNCT
admet-1513	331	33	.	.	PUNCT
admet-1513	332	1	all	all	DET
admet-1513	332	2	these	these	DET
admet-1513	332	3	factors	factor	NOUN
admet-1513	332	4	hamper	hamper	VERB
admet-1513	332	5	the	the	DET
admet-1513	332	6	translational	translational	ADJ
admet-1513	332	7	potential	potential	NOUN
admet-1513	332	8	of	of	ADP
admet-1513	332	9	miniguts	minigut	NOUN
admet-1513	332	10	in	in	ADP
admet-1513	332	11	obtaining	obtain	VERB
admet-1513	332	12	robust	robust	ADJ
admet-1513	332	13	statistical	statistical	ADJ
admet-1513	332	14	results	result	NOUN
admet-1513	332	15	in	in	ADP
admet-1513	332	16	pk	pk	NOUN
admet-1513	332	17	profiles	profile	NOUN
admet-1513	332	18	of	of	ADP
admet-1513	332	19	the	the	DET
admet-1513	332	20	novel	novel	ADJ
admet-1513	332	21	drug	drug	NOUN
admet-1513	332	22	entities	entity	NOUN
admet-1513	332	23	[	[	X
admet-1513	332	24	5,129	5,129	NUM
admet-1513	332	25	]	]	PUNCT
admet-1513	332	26	.	.	PUNCT
admet-1513	333	1	hence	hence	ADV
admet-1513	333	2	further	further	ADJ
admet-1513	333	3	efforts	effort	NOUN
admet-1513	333	4	are	be	AUX
admet-1513	333	5	required	require	VERB
admet-1513	333	6	in	in	ADP
admet-1513	333	7	the	the	DET
admet-1513	333	8	development	development	NOUN
admet-1513	333	9	of	of	ADP
admet-1513	333	10	cost	cost	NOUN
admet-1513	333	11	-	-	PUNCT
admet-1513	333	12	effective	effective	ADJ
admet-1513	333	13	and	and	CCONJ
admet-1513	333	14	much	much	ADV
admet-1513	333	15	feasible	feasible	ADJ
admet-1513	333	16	organotypic	organotypic	ADJ
admet-1513	333	17	research	research	NOUN
admet-1513	333	18	by	by	ADP
admet-1513	333	19	considering	consider	VERB
admet-1513	333	20	its	its	PRON
admet-1513	333	21	potentiality	potentiality	NOUN
admet-1513	333	22	and	and	CCONJ
admet-1513	333	23	reducing	reduce	VERB
admet-1513	333	24	animal	animal	NOUN
admet-1513	333	25	testing	testing	NOUN
admet-1513	333	26	in	in	ADP
admet-1513	333	27	drug	drug	NOUN
admet-1513	333	28	discovery	discovery	NOUN
admet-1513	333	29	and	and	CCONJ
admet-1513	333	30	development	development	NOUN
admet-1513	333	31	[	[	X
admet-1513	333	32	130	130	NUM
admet-1513	333	33	]	]	PUNCT
admet-1513	333	34	.	.	PUNCT
admet-1513	334	1	liver	liver	NOUN
admet-1513	334	2	models	model	NOUN
admet-1513	334	3	for	for	ADP
admet-1513	334	4	drug	drug	NOUN
admet-1513	334	5	metabolism	metabolism	NOUN
admet-1513	334	6	currently	currently	ADV
admet-1513	334	7	,	,	PUNCT
admet-1513	334	8	the	the	DET
admet-1513	334	9	majority	majority	NOUN
admet-1513	334	10	of	of	ADP
admet-1513	334	11	the	the	DET
admet-1513	334	12	studies	study	NOUN
admet-1513	334	13	use	use	VERB
admet-1513	334	14	2d	2d	NOUN
admet-1513	334	15	in	in	ADP
admet-1513	334	16	vitro	vitro	X
admet-1513	334	17	models	model	NOUN
admet-1513	334	18	and	and	CCONJ
admet-1513	334	19	animal	animal	NOUN
admet-1513	334	20	models	model	NOUN
admet-1513	334	21	for	for	ADP
admet-1513	334	22	understanding	understand	VERB
admet-1513	334	23	drug	drug	NOUN
admet-1513	334	24	metabolism	metabolism	NOUN
admet-1513	334	25	;	;	PUNCT
admet-1513	334	26	however	however	ADV
admet-1513	334	27	,	,	PUNCT
admet-1513	334	28	the	the	DET
admet-1513	334	29	complexity	complexity	NOUN
admet-1513	334	30	of	of	ADP
admet-1513	334	31	human	human	NOUN
admet-1513	334	32	in	in	ADP
admet-1513	334	33	vivo	vivo	NOUN
admet-1513	334	34	and	and	CCONJ
admet-1513	334	35	interspecies	interspecie	VERB
admet-1513	334	36	variation	variation	NOUN
admet-1513	334	37	results	result	NOUN
admet-1513	334	38	in	in	ADP
admet-1513	334	39	variations	variation	NOUN
admet-1513	334	40	in	in	ADP
admet-1513	334	41	the	the	DET
admet-1513	334	42	actual	actual	ADJ
admet-1513	334	43	prediction	prediction	NOUN
admet-1513	334	44	of	of	ADP
admet-1513	334	45	drug	drug	NOUN
admet-1513	334	46	metabolism	metabolism	NOUN
admet-1513	334	47	.	.	PUNCT
admet-1513	335	1	further	far	ADV
admet-1513	335	2	,	,	PUNCT
admet-1513	335	3	these	these	DET
admet-1513	335	4	animal	animal	NOUN
admet-1513	335	5	models	model	NOUN
admet-1513	335	6	are	be	AUX
admet-1513	335	7	unsuitable	unsuitable	ADJ
admet-1513	335	8	for	for	ADP
admet-1513	335	9	high	high	ADJ
admet-1513	335	10	throughput	throughput	NOUN
admet-1513	335	11	screening	screening	NOUN
admet-1513	335	12	of	of	ADP
admet-1513	335	13	small	small	ADJ
admet-1513	335	14	-	-	PUNCT
admet-1513	335	15	library	library	NOUN
admet-1513	335	16	molecules	molecule	NOUN
admet-1513	335	17	for	for	ADP
admet-1513	335	18	identifying	identify	VERB
admet-1513	335	19	drugs	drug	NOUN
admet-1513	335	20	for	for	ADP
admet-1513	335	21	disease	disease	NOUN
admet-1513	335	22	treatment	treatment	NOUN
admet-1513	335	23	[	[	X
admet-1513	335	24	131	131	NUM
admet-1513	335	25	]	]	PUNCT
admet-1513	335	26	.	.	PUNCT
admet-1513	336	1	but	but	CCONJ
admet-1513	336	2	can	can	AUX
admet-1513	336	3	be	be	AUX
admet-1513	336	4	achieved	achieve	VERB
admet-1513	336	5	by	by	ADP
admet-1513	336	6	using	use	VERB
admet-1513	336	7	2d	2d	NUM
admet-1513	336	8	hipsc	hipsc	ADV
admet-1513	336	9	-	-	PUNCT
admet-1513	336	10	derived	derive	VERB
admet-1513	336	11	hepatocytes	hepatocyte	NOUN
admet-1513	336	12	platforms	platform	NOUN
admet-1513	337	1	[	[	X
admet-1513	337	2	132	132	NUM
admet-1513	337	3	-	-	SYM
admet-1513	337	4	134	134	NUM
admet-1513	337	5	]	]	PUNCT
admet-1513	337	6	.	.	PUNCT
admet-1513	338	1	small	small	ADJ
admet-1513	338	2	drug	drug	NOUN
admet-1513	338	3	molecules	molecule	NOUN
admet-1513	338	4	/	/	SYM
admet-1513	338	5	drug	drug	NOUN
admet-1513	338	6	libraries	library	NOUN
admet-1513	338	7	aimed	aim	VERB
admet-1513	338	8	at	at	ADP
admet-1513	338	9	the	the	DET
admet-1513	338	10	attenuation	attenuation	NOUN
admet-1513	338	11	or	or	CCONJ
admet-1513	338	12	reversion	reversion	NOUN
admet-1513	338	13	of	of	ADP
admet-1513	338	14	the	the	DET
admet-1513	338	15	effects	effect	NOUN
admet-1513	338	16	of	of	ADP
admet-1513	338	17	diseases	disease	NOUN
admet-1513	338	18	like	like	ADP
admet-1513	338	19	alpha-1	alpha-1	NOUN
admet-1513	338	20	-	-	PUNCT
admet-1513	338	21	antitrypsin	antitrypsin	NOUN
admet-1513	338	22	(	(	PUNCT
admet-1513	338	23	aat	aat	NOUN
admet-1513	338	24	)	)	PUNCT
admet-1513	338	25	deficiency	deficiency	NOUN
admet-1513	338	26	[	[	X
admet-1513	338	27	135	135	NUM
admet-1513	338	28	]	]	PUNCT
admet-1513	338	29	,	,	PUNCT
admet-1513	338	30	familial	familial	ADJ
admet-1513	338	31	hypercholesterolemia	hypercholesterolemia	NOUN
admet-1513	339	1	[	[	X
admet-1513	339	2	136	136	NUM
admet-1513	339	3	]	]	PUNCT
admet-1513	339	4	,	,	PUNCT
admet-1513	339	5	and	and	CCONJ
admet-1513	339	6	mitochondrial	mitochondrial	ADJ
admet-1513	339	7	dna	dna	NOUN
admet-1513	339	8	depletion	depletion	NOUN
admet-1513	339	9	syndrome	syndrome	NOUN
admet-1513	339	10	(	(	PUNCT
admet-1513	339	11	mtdps3	mtdps3	NOUN
admet-1513	339	12	)	)	PUNCT
admet-1513	339	13	[	[	X
admet-1513	339	14	137	137	NUM
admet-1513	339	15	]	]	PUNCT
admet-1513	339	16	have	have	AUX
admet-1513	339	17	been	be	AUX
admet-1513	339	18	achieved	achieve	VERB
admet-1513	339	19	by	by	ADP
admet-1513	339	20	using	use	VERB
admet-1513	339	21	hipsc	hipsc	ADJ
admet-1513	339	22	derived	derive	VERB
admet-1513	339	23	hepatocytes	hepatocyte	NOUN
admet-1513	339	24	platforms	platform	NOUN
admet-1513	339	25	.	.	PUNCT
admet-1513	340	1	similarly	similarly	ADV
admet-1513	340	2	,	,	PUNCT
admet-1513	340	3	these	these	DET
admet-1513	340	4	platforms	platform	NOUN
admet-1513	340	5	were	be	AUX
admet-1513	340	6	also	also	ADV
admet-1513	340	7	used	use	VERB
admet-1513	340	8	for	for	ADP
admet-1513	340	9	toxicity	toxicity	NOUN
admet-1513	340	10	assessment	assessment	NOUN
admet-1513	340	11	of	of	ADP
admet-1513	340	12	test	test	NOUN
admet-1513	340	13	compounds	compound	NOUN
admet-1513	340	14	known	know	VERB
admet-1513	340	15	to	to	PART
admet-1513	340	16	be	be	AUX
admet-1513	340	17	toxic	toxic	ADJ
admet-1513	340	18	and	and	CCONJ
admet-1513	340	19	non	non	ADJ
admet-1513	340	20	-	-	ADJ
admet-1513	340	21	toxic	toxic	ADJ
admet-1513	340	22	for	for	ADP
admet-1513	340	23	cell	cell	NOUN
admet-1513	340	24	morphology	morphology	NOUN
admet-1513	340	25	and	and	CCONJ
admet-1513	340	26	viability	viability	NOUN
admet-1513	341	1	[	[	X
admet-1513	341	2	138	138	NUM
admet-1513	341	3	-	-	SYM
admet-1513	341	4	140	140	NUM
admet-1513	341	5	]	]	PUNCT
admet-1513	341	6	.	.	PUNCT
admet-1513	342	1	however	however	ADV
admet-1513	342	2	,	,	PUNCT
admet-1513	342	3	all	all	DET
admet-1513	342	4	these	these	DET
admet-1513	342	5	studies	study	NOUN
admet-1513	342	6	are	be	AUX
admet-1513	342	7	mainly	mainly	ADV
admet-1513	342	8	focused	focus	VERB
admet-1513	342	9	on	on	ADP
admet-1513	342	10	hepatocytes	hepatocyte	NOUN
admet-1513	342	11	,	,	PUNCT
admet-1513	342	12	but	but	CCONJ
admet-1513	342	13	as	as	SCONJ
admet-1513	342	14	we	we	PRON
admet-1513	342	15	know	know	VERB
admet-1513	342	16	that	that	SCONJ
admet-1513	342	17	the	the	DET
admet-1513	342	18	liver	liver	NOUN
admet-1513	342	19	is	be	AUX
admet-1513	342	20	a	a	DET
admet-1513	342	21	complex	complex	ADJ
admet-1513	342	22	organ	organ	NOUN
admet-1513	342	23	consisting	consisting	NOUN
admet-1513	342	24	of	of	ADP
admet-1513	342	25	different	different	ADJ
admet-1513	342	26	cell	cell	NOUN
admet-1513	342	27	types	type	NOUN
admet-1513	342	28	like	like	ADP
admet-1513	342	29	parenchymal	parenchymal	ADJ
admet-1513	342	30	cells	cell	NOUN
admet-1513	342	31	,	,	PUNCT
admet-1513	342	32	which	which	PRON
admet-1513	342	33	include	include	VERB
admet-1513	342	34	hepatocytes	hepatocyte	NOUN
admet-1513	342	35	and	and	CCONJ
admet-1513	342	36	cholangiocytes	cholangiocyte	NOUN
admet-1513	342	37	and	and	CCONJ
admet-1513	342	38	non	non	ADJ
admet-1513	342	39	-	-	ADJ
admet-1513	342	40	parenchymal	parenchymal	ADJ
admet-1513	342	41	cells	cell	NOUN
admet-1513	342	42	,	,	PUNCT
admet-1513	342	43	including	include	VERB
admet-1513	342	44	kupffer	kupffer	NOUN
admet-1513	342	45	cells	cell	NOUN
admet-1513	342	46	,	,	PUNCT
admet-1513	342	47	liver	liver	NOUN
admet-1513	342	48	sinusoidal	sinusoidal	ADJ
admet-1513	342	49	endothelial	endothelial	NOUN
admet-1513	342	50	cells	cell	NOUN
admet-1513	342	51	(	(	PUNCT
admet-1513	342	52	lsec	lsec	PROPN
admet-1513	342	53	)	)	PUNCT
admet-1513	342	54	,	,	PUNCT
admet-1513	342	55	hepatic	hepatic	ADJ
admet-1513	342	56	stellate	stellate	ADJ
admet-1513	342	57	cells	cell	NOUN
admet-1513	342	58	,	,	PUNCT
admet-1513	342	59	liver	liver	NOUN
admet-1513	342	60	infiltrating	infiltrate	VERB
admet-1513	342	61	lymphocytes	lymphocyte	NOUN
admet-1513	342	62	[	[	X
admet-1513	342	63	141,142	141,142	NUM
admet-1513	342	64	]	]	PUNCT
admet-1513	342	65	.	.	PUNCT
admet-1513	343	1	none	none	NOUN
admet-1513	343	2	have	have	AUX
admet-1513	343	3	included	include	VERB
admet-1513	343	4	the	the	DET
admet-1513	343	5	non	non	ADJ
admet-1513	343	6	-	-	ADJ
admet-1513	343	7	parenchymal	parenchymal	ADJ
admet-1513	343	8	cells	cell	NOUN
admet-1513	343	9	,	,	PUNCT
admet-1513	343	10	which	which	PRON
admet-1513	343	11	hold	hold	VERB
admet-1513	343	12	great	great	ADJ
admet-1513	343	13	importance	importance	NOUN
admet-1513	343	14	in	in	ADP
admet-1513	343	15	liver	liver	NOUN
admet-1513	343	16	physiology	physiology	NOUN
admet-1513	343	17	.	.	PUNCT
admet-1513	344	1	for	for	ADP
admet-1513	344	2	example	example	NOUN
admet-1513	344	3	,	,	PUNCT
admet-1513	344	4	lsecs	lsec	NOUN
admet-1513	344	5	are	be	AUX
admet-1513	344	6	involved	involve	VERB
admet-1513	344	7	in	in	ADP
admet-1513	344	8	most	most	ADJ
admet-1513	344	9	liver	liver	NOUN
admet-1513	344	10	diseases	disease	NOUN
admet-1513	344	11	,	,	PUNCT
admet-1513	344	12	making	make	VERB
admet-1513	344	13	them	they	PRON
admet-1513	344	14	an	an	DET
admet-1513	344	15	attractive	attractive	ADJ
admet-1513	344	16	therapeutic	therapeutic	ADJ
admet-1513	344	17	target	target	NOUN
admet-1513	345	1	[	[	X
admet-1513	345	2	143	143	NUM
admet-1513	345	3	]	]	PUNCT
admet-1513	345	4	.	.	PUNCT
admet-1513	346	1	moreover	moreover	ADV
admet-1513	346	2	,	,	PUNCT
admet-1513	346	3	kupffer	kupffer	NOUN
admet-1513	346	4	cells	cell	NOUN
admet-1513	346	5	also	also	ADV
admet-1513	346	6	played	play	VERB
admet-1513	346	7	a	a	DET
admet-1513	346	8	crucial	crucial	ADJ
admet-1513	346	9	role	role	NOUN
admet-1513	346	10	in	in	ADP
admet-1513	346	11	dili	dili	PROPN
admet-1513	346	12	and	and	CCONJ
admet-1513	346	13	other	other	ADJ
admet-1513	346	14	liver	liver	NOUN
admet-1513	346	15	diseases	disease	NOUN
admet-1513	346	16	and	and	CCONJ
admet-1513	346	17	were	be	AUX
admet-1513	346	18	not	not	PART
admet-1513	346	19	used	use	VERB
admet-1513	346	20	for	for	ADP
admet-1513	346	21	drug	drug	NOUN
admet-1513	346	22	screening	screening	NOUN
admet-1513	346	23	and	and	CCONJ
admet-1513	346	24	metabolism	metabolism	NOUN
admet-1513	346	25	.	.	PUNCT
admet-1513	347	1	although	although	SCONJ
admet-1513	347	2	primary	primary	ADJ
admet-1513	347	3	human	human	ADJ
admet-1513	347	4	hepatocytes	hepatocyte	NOUN
admet-1513	347	5	are	be	AUX
admet-1513	347	6	regarded	regard	VERB
admet-1513	347	7	as	as	ADP
admet-1513	347	8	the	the	DET
admet-1513	347	9	gold	gold	ADJ
admet-1513	347	10	standard	standard	ADJ
admet-1513	347	11	model	model	NOUN
admet-1513	347	12	for	for	ADP
admet-1513	347	13	determining	determine	VERB
admet-1513	347	14	hepatic	hepatic	ADJ
admet-1513	347	15	metabolism	metabolism	NOUN
admet-1513	347	16	,	,	PUNCT
admet-1513	347	17	the	the	DET
admet-1513	347	18	decline	decline	NOUN
admet-1513	347	19	in	in	ADP
admet-1513	347	20	proliferative	proliferative	ADJ
admet-1513	347	21	potential	potential	ADJ
admet-1513	347	22	and	and	CCONJ
admet-1513	347	23	long	long	ADJ
admet-1513	347	24	-	-	PUNCT
admet-1513	347	25	term	term	NOUN
admet-1513	347	26	functionality	functionality	NOUN
admet-1513	347	27	limited	limit	VERB
admet-1513	347	28	its	its	PRON
admet-1513	347	29	studies	study	NOUN
admet-1513	347	30	in	in	ADP
admet-1513	347	31	vitro	vitro	X
admet-1513	347	32	[	[	X
admet-1513	347	33	144	144	NUM
admet-1513	347	34	]	]	PUNCT
admet-1513	347	35	.	.	PUNCT
admet-1513	348	1	to	to	PART
admet-1513	348	2	overcome	overcome	VERB
admet-1513	348	3	the	the	DET
admet-1513	348	4	limitations	limitation	NOUN
admet-1513	348	5	of	of	ADP
admet-1513	348	6	2d	2d	NUM
admet-1513	348	7	hepatocytes	hepatocyte	VERB
admet-1513	348	8	cultures	culture	NOUN
admet-1513	348	9	and	and	CCONJ
admet-1513	348	10	to	to	PART
admet-1513	348	11	achieve	achieve	VERB
admet-1513	348	12	reduced	reduce	VERB
admet-1513	348	13	animal	animal	NOUN
admet-1513	348	14	usage	usage	NOUN
admet-1513	348	15	in	in	ADP
admet-1513	348	16	drug	drug	NOUN
admet-1513	348	17	discovery	discovery	NOUN
admet-1513	348	18	programs	program	NOUN
admet-1513	348	19	,	,	PUNCT
admet-1513	348	20	various	various	ADJ
admet-1513	348	21	researchers	researcher	NOUN
admet-1513	348	22	developed	develop	VERB
admet-1513	348	23	alternative	alternative	ADJ
admet-1513	348	24	3d	3d	NOUN
admet-1513	348	25	models	model	NOUN
admet-1513	348	26	utilizing	utilize	VERB
admet-1513	348	27	hipsc	hipsc	ADJ
admet-1513	348	28	and	and	CCONJ
admet-1513	348	29	generated	generate	VERB
admet-1513	348	30	liveron	liveron	NOUN
admet-1513	348	31	-	-	PUNCT
admet-1513	348	32	chip	chip	NOUN
admet-1513	348	33	or	or	CCONJ
admet-1513	348	34	mps	mp	NOUN
admet-1513	349	1	[	[	X
admet-1513	349	2	145	145	NUM
admet-1513	349	3	]	]	PUNCT
admet-1513	349	4	and	and	CCONJ
admet-1513	349	5	organoids	organoid	NOUN
admet-1513	350	1	[	[	X
admet-1513	350	2	146,147	146,147	NUM
admet-1513	350	3	]	]	PUNCT
admet-1513	350	4	for	for	ADP
admet-1513	350	5	studying	study	VERB
admet-1513	350	6	the	the	DET
admet-1513	350	7	drug	drug	NOUN
admet-1513	350	8	metabolism	metabolism	NOUN
admet-1513	350	9	,	,	PUNCT
admet-1513	350	10	ddi	ddi	PROPN
admet-1513	350	11	,	,	PUNCT
admet-1513	350	12	clearance	clearance	NOUN
admet-1513	350	13	and	and	CCONJ
admet-1513	350	14	bioavailability	bioavailability	NOUN
admet-1513	350	15	[	[	X
admet-1513	350	16	148	148	NUM
admet-1513	350	17	]	]	PUNCT
admet-1513	350	18	.	.	PUNCT
admet-1513	351	1	currently	currently	ADV
admet-1513	351	2	,	,	PUNCT
admet-1513	351	3	the	the	DET
admet-1513	351	4	most	most	ADV
admet-1513	351	5	challenging	challenging	ADJ
admet-1513	351	6	aspect	aspect	NOUN
admet-1513	351	7	is	be	AUX
admet-1513	351	8	the	the	DET
admet-1513	351	9	generation	generation	NOUN
admet-1513	351	10	of	of	ADP
admet-1513	351	11	physiologically	physiologically	ADV
admet-1513	351	12	and	and	CCONJ
admet-1513	351	13	pathologically	pathologically	ADV
admet-1513	351	14	similar	similar	ADJ
admet-1513	351	15	hepatic	hepatic	ADJ
admet-1513	351	16	models	model	NOUN
admet-1513	351	17	to	to	ADP
admet-1513	351	18	that	that	PRON
admet-1513	351	19	of	of	ADP
admet-1513	351	20	the	the	DET
admet-1513	351	21	functional	functional	ADJ
admet-1513	351	22	human	human	ADJ
admet-1513	351	23	liver	liver	NOUN
admet-1513	351	24	and	and	CCONJ
admet-1513	351	25	maintaining	maintain	VERB
admet-1513	351	26	cellular	cellular	ADJ
admet-1513	351	27	viability	viability	NOUN
admet-1513	351	28	for	for	ADP
admet-1513	351	29	several	several	ADJ
admet-1513	351	30	days	day	NOUN
admet-1513	351	31	.	.	PUNCT
admet-1513	352	1	considering	consider	VERB
admet-1513	352	2	these	these	PRON
admet-1513	352	3	,	,	PUNCT
admet-1513	352	4	there	there	PRON
admet-1513	352	5	is	be	VERB
admet-1513	352	6	an	an	DET
admet-1513	352	7	urgent	urgent	ADJ
admet-1513	352	8	requirement	requirement	NOUN
admet-1513	352	9	for	for	ADP
admet-1513	352	10	the	the	DET
admet-1513	352	11	development	development	NOUN
admet-1513	352	12	of	of	ADP
admet-1513	352	13	robust	robust	ADJ
admet-1513	352	14	protocols	protocol	NOUN
admet-1513	352	15	admet	admet	X
admet-1513	352	16	&	&	CCONJ
admet-1513	352	17	dmpk	dmpk	PROPN
admet-1513	352	18	11(1	11(1	NUM
admet-1513	352	19	)	)	PUNCT
admet-1513	352	20	(	(	PUNCT
admet-1513	352	21	2023	2023	NUM
admet-1513	352	22	)	)	PUNCT
admet-1513	352	23	1	1	NUM
admet-1513	352	24	-	-	SYM
admet-1513	352	25	32	32	NUM
admet-1513	352	26	2d	2d	NOUN
admet-1513	352	27	and	and	CCONJ
admet-1513	352	28	3d	3d	NOUN
admet-1513	352	29	adme	adme	PROPN
admet-1513	352	30	-	-	PUNCT
admet-1513	352	31	tox	tox	NOUN
admet-1513	352	32	cell	cell	NOUN
admet-1513	352	33	culture	culture	NOUN
admet-1513	352	34	screening	screen	VERB
admet-1513	352	35	:	:	PUNCT
admet-1513	352	36	a	a	DET
admet-1513	352	37	review	review	NOUN
admet-1513	352	38	doi	doi	NOUN
admet-1513	352	39	:	:	PUNCT
admet-1513	352	40	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	352	41	13	13	NUM
admet-1513	352	42	for	for	ADP
admet-1513	352	43	generating	generate	VERB
admet-1513	352	44	liver	liver	NOUN
admet-1513	352	45	organoids	organoid	NOUN
admet-1513	352	46	or	or	CCONJ
admet-1513	352	47	liver	liver	NOUN
admet-1513	352	48	mps	mp	NOUN
admet-1513	352	49	in	in	ADP
admet-1513	352	50	a	a	DET
admet-1513	352	51	scalable	scalable	ADJ
admet-1513	352	52	and	and	CCONJ
admet-1513	352	53	miniature	miniature	ADJ
admet-1513	352	54	fashion	fashion	NOUN
admet-1513	352	55	.	.	PUNCT
admet-1513	353	1	the	the	DET
admet-1513	353	2	development	development	NOUN
admet-1513	353	3	of	of	ADP
admet-1513	353	4	3d	3d	PROPN
admet-1513	353	5	liver	liver	NOUN
admet-1513	353	6	models	model	NOUN
admet-1513	353	7	is	be	AUX
admet-1513	353	8	becoming	become	VERB
admet-1513	353	9	increasingly	increasingly	ADV
admet-1513	353	10	important	important	ADJ
admet-1513	353	11	in	in	ADP
admet-1513	353	12	drug	drug	NOUN
admet-1513	353	13	discovery	discovery	NOUN
admet-1513	353	14	,	,	PUNCT
admet-1513	353	15	as	as	SCONJ
admet-1513	353	16	they	they	PRON
admet-1513	353	17	can	can	AUX
admet-1513	353	18	replicate	replicate	VERB
admet-1513	353	19	biological	biological	ADJ
admet-1513	353	20	aspects	aspect	NOUN
admet-1513	353	21	like	like	ADP
admet-1513	353	22	spatial	spatial	ADJ
admet-1513	353	23	arrangement	arrangement	NOUN
admet-1513	353	24	,	,	PUNCT
admet-1513	353	25	cell	cell	NOUN
admet-1513	353	26	-	-	PUNCT
admet-1513	353	27	cell	cell	NOUN
admet-1513	353	28	and	and	CCONJ
admet-1513	353	29	cell	cell	NOUN
admet-1513	353	30	–	–	PUNCT
admet-1513	353	31	ecm	ecm	NOUN
admet-1513	353	32	interactions	interaction	NOUN
admet-1513	353	33	[	[	X
admet-1513	353	34	141	141	NUM
admet-1513	353	35	]	]	PUNCT
admet-1513	353	36	.	.	PUNCT
admet-1513	354	1	researchers	researcher	NOUN
admet-1513	354	2	have	have	AUX
admet-1513	354	3	developed	develop	VERB
admet-1513	354	4	various	various	ADJ
admet-1513	354	5	protocols	protocol	NOUN
admet-1513	354	6	for	for	ADP
admet-1513	354	7	the	the	DET
admet-1513	354	8	generation	generation	NOUN
admet-1513	354	9	of	of	ADP
admet-1513	354	10	organoids	organoid	NOUN
admet-1513	354	11	,	,	PUNCT
admet-1513	354	12	and	and	CCONJ
admet-1513	354	13	most	most	ADV
admet-1513	354	14	prominently	prominently	ADV
admet-1513	354	15	,	,	PUNCT
admet-1513	354	16	the	the	DET
admet-1513	354	17	use	use	NOUN
admet-1513	354	18	of	of	ADP
admet-1513	354	19	hipsc	hipsc	PROPN
admet-1513	354	20	has	have	AUX
admet-1513	354	21	enabled	enable	VERB
admet-1513	354	22	the	the	DET
admet-1513	354	23	generation	generation	NOUN
admet-1513	354	24	of	of	ADP
admet-1513	354	25	more	more	ADJ
admet-1513	354	26	complex	complex	ADJ
admet-1513	354	27	organoids	organoid	NOUN
admet-1513	354	28	containing	contain	VERB
admet-1513	354	29	different	different	ADJ
admet-1513	354	30	cell	cell	NOUN
admet-1513	354	31	types	type	NOUN
admet-1513	354	32	of	of	ADP
admet-1513	354	33	the	the	DET
admet-1513	354	34	organ	organ	NOUN
admet-1513	355	1	[	[	X
admet-1513	355	2	142	142	NUM
admet-1513	355	3	]	]	PUNCT
admet-1513	355	4	.	.	PUNCT
admet-1513	356	1	reports	report	NOUN
admet-1513	356	2	citing	cite	VERB
admet-1513	356	3	the	the	DET
admet-1513	356	4	generation	generation	NOUN
admet-1513	356	5	of	of	ADP
admet-1513	356	6	liver	liver	NOUN
admet-1513	356	7	organoids	organoid	NOUN
admet-1513	356	8	from	from	ADP
admet-1513	356	9	hipsc	hipsc	NOUN
admet-1513	356	10	are	be	AUX
admet-1513	356	11	increasing	increase	VERB
admet-1513	356	12	daily	daily	ADV
admet-1513	357	1	[	[	X
admet-1513	357	2	147,149	147,149	NUM
admet-1513	357	3	-	-	SYM
admet-1513	357	4	151	151	NUM
admet-1513	357	5	]	]	PUNCT
admet-1513	357	6	.	.	PUNCT
admet-1513	358	1	initially	initially	ADV
admet-1513	358	2	,	,	PUNCT
admet-1513	358	3	the	the	DET
admet-1513	358	4	liver	liver	NOUN
admet-1513	358	5	organoids	organoid	NOUN
admet-1513	358	6	were	be	AUX
admet-1513	358	7	generated	generate	VERB
admet-1513	358	8	from	from	ADP
admet-1513	358	9	the	the	DET
admet-1513	358	10	co	co	NOUN
admet-1513	358	11	-	-	NOUN
admet-1513	358	12	culturing	culture	VERB
admet-1513	358	13	of	of	ADP
admet-1513	358	14	different	different	ADJ
admet-1513	358	15	cell	cell	NOUN
admet-1513	358	16	types	type	NOUN
admet-1513	358	17	.	.	PUNCT
admet-1513	359	1	later	later	ADV
admet-1513	359	2	advanced	advanced	ADJ
admet-1513	359	3	techniques	technique	NOUN
admet-1513	359	4	were	be	AUX
admet-1513	359	5	developed	develop	VERB
admet-1513	359	6	for	for	ADP
admet-1513	359	7	the	the	DET
admet-1513	359	8	generation	generation	NOUN
admet-1513	359	9	of	of	ADP
admet-1513	359	10	organoids	organoid	NOUN
admet-1513	359	11	from	from	ADP
admet-1513	359	12	the	the	DET
admet-1513	359	13	homogenous	homogenous	ADJ
admet-1513	359	14	population	population	NOUN
admet-1513	359	15	[	[	X
admet-1513	359	16	147,152,153	147,152,153	NUM
admet-1513	359	17	]	]	PUNCT
admet-1513	359	18	.	.	PUNCT
admet-1513	360	1	takebe	takebe	NOUN
admet-1513	360	2	and	and	CCONJ
admet-1513	360	3	colleagues	colleague	NOUN
admet-1513	361	1	[	[	X
admet-1513	361	2	149	149	NUM
admet-1513	361	3	]	]	PUNCT
admet-1513	361	4	have	have	AUX
admet-1513	361	5	generated	generate	VERB
admet-1513	361	6	liver	liver	NOUN
admet-1513	361	7	bud	bud	ADJ
admet-1513	361	8	organoids	organoid	NOUN
admet-1513	361	9	by	by	ADP
admet-1513	361	10	mixing	mix	VERB
admet-1513	361	11	the	the	DET
admet-1513	361	12	hepatic	hepatic	ADJ
admet-1513	361	13	endodermal	endodermal	ADJ
admet-1513	361	14	cells	cell	NOUN
admet-1513	361	15	generated	generate	VERB
admet-1513	361	16	from	from	ADP
admet-1513	361	17	hipsc	hipsc	ADJ
admet-1513	361	18	,	,	PUNCT
admet-1513	361	19	with	with	ADP
admet-1513	361	20	human	human	ADJ
admet-1513	361	21	umbilical	umbilical	ADJ
admet-1513	361	22	vein	vein	ADJ
admet-1513	361	23	endothelial	endothelial	NOUN
admet-1513	361	24	cells	cell	NOUN
admet-1513	361	25	and	and	CCONJ
admet-1513	361	26	human	human	ADJ
admet-1513	361	27	mesenchymal	mesenchymal	NOUN
admet-1513	361	28	stem	stem	NOUN
admet-1513	361	29	cells	cell	NOUN
admet-1513	361	30	.	.	PUNCT
admet-1513	362	1	for	for	ADP
admet-1513	362	2	maturation	maturation	NOUN
admet-1513	362	3	of	of	ADP
admet-1513	362	4	these	these	DET
admet-1513	362	5	bud	bud	ADJ
admet-1513	362	6	organoids	organoid	NOUN
admet-1513	362	7	,	,	PUNCT
admet-1513	362	8	they	they	PRON
admet-1513	362	9	supplemented	supplement	VERB
admet-1513	362	10	the	the	DET
admet-1513	362	11	medium	medium	NOUN
admet-1513	362	12	with	with	ADP
admet-1513	362	13	an	an	DET
admet-1513	362	14	endothelial	endothelial	ADJ
admet-1513	362	15	growth	growth	NOUN
admet-1513	362	16	medium	medium	NOUN
admet-1513	362	17	resulting	result	VERB
admet-1513	362	18	in	in	ADP
admet-1513	362	19	improved	improved	ADJ
admet-1513	362	20	functionality	functionality	NOUN
admet-1513	362	21	.	.	PUNCT
admet-1513	363	1	more	more	ADV
admet-1513	363	2	recently	recently	ADV
admet-1513	363	3	,	,	PUNCT
admet-1513	363	4	the	the	DET
admet-1513	363	5	same	same	ADJ
admet-1513	363	6	group	group	NOUN
admet-1513	363	7	has	have	AUX
admet-1513	363	8	also	also	ADV
admet-1513	363	9	developed	develop	VERB
admet-1513	363	10	complex	complex	ADJ
admet-1513	363	11	organoids	organoid	NOUN
admet-1513	363	12	containing	contain	VERB
admet-1513	363	13	hepatocytes	hepatocyte	NOUN
admet-1513	363	14	,	,	PUNCT
admet-1513	363	15	endothelial	endothelial	ADJ
admet-1513	363	16	cells	cell	NOUN
admet-1513	363	17	and	and	CCONJ
admet-1513	363	18	stm	stm	NOUN
admet-1513	363	19	from	from	ADP
admet-1513	363	20	hipsc	hipsc	PROPN
admet-1513	363	21	[	[	X
admet-1513	363	22	150	150	NUM
admet-1513	363	23	]	]	PUNCT
admet-1513	363	24	.	.	PUNCT
admet-1513	364	1	a	a	DET
admet-1513	364	2	similar	similar	ADJ
admet-1513	364	3	approach	approach	NOUN
admet-1513	364	4	has	have	AUX
admet-1513	364	5	been	be	AUX
admet-1513	364	6	utilized	utilize	VERB
admet-1513	364	7	by	by	ADP
admet-1513	364	8	pettinato	pettinato	NOUN
admet-1513	364	9	and	and	CCONJ
admet-1513	364	10	colleagues	colleague	NOUN
admet-1513	364	11	[	[	X
admet-1513	364	12	151	151	NUM
admet-1513	364	13	]	]	PUNCT
admet-1513	364	14	and	and	CCONJ
admet-1513	364	15	cocultured	coculture	VERB
admet-1513	364	16	hipsc	hipsc	PROPN
admet-1513	364	17	along	along	ADP
admet-1513	364	18	with	with	ADP
admet-1513	364	19	human	human	ADJ
admet-1513	364	20	adipose	adipose	X
admet-1513	364	21	microvascular	microvascular	ADJ
admet-1513	364	22	endothelial	endothelial	ADJ
admet-1513	364	23	cells	cell	NOUN
admet-1513	364	24	for	for	ADP
admet-1513	364	25	the	the	DET
admet-1513	364	26	generation	generation	NOUN
admet-1513	364	27	of	of	ADP
admet-1513	364	28	organoids	organoid	NOUN
admet-1513	364	29	.	.	PUNCT
admet-1513	365	1	they	they	PRON
admet-1513	365	2	demonstrated	demonstrate	VERB
admet-1513	365	3	that	that	SCONJ
admet-1513	365	4	their	their	PRON
admet-1513	365	5	organoids	organoid	NOUN
admet-1513	365	6	contain	contain	VERB
admet-1513	365	7	89	89	NUM
admet-1513	365	8	%	%	NOUN
admet-1513	365	9	albumin+	albumin+	PROPN
admet-1513	365	10	and	and	CCONJ
admet-1513	365	11	15	15	NUM
admet-1513	365	12	%	%	NOUN
admet-1513	365	13	cd31	cd31	PROPN
admet-1513	365	14	+	+	NUM
admet-1513	365	15	cells	cell	NOUN
admet-1513	365	16	and	and	CCONJ
admet-1513	365	17	improved	improve	VERB
admet-1513	365	18	human	human	ADJ
admet-1513	365	19	hepatic	hepatic	ADJ
admet-1513	365	20	functions	function	NOUN
admet-1513	365	21	similar	similar	ADJ
admet-1513	365	22	to	to	ADP
admet-1513	365	23	in	in	ADP
admet-1513	365	24	vivo	vivo	ADJ
admet-1513	365	25	liver	liver	NOUN
admet-1513	365	26	cells	cell	NOUN
admet-1513	365	27	.	.	PUNCT
admet-1513	366	1	liver	liver	NOUN
admet-1513	366	2	organoids	organoid	NOUN
admet-1513	366	3	were	be	AUX
admet-1513	366	4	generated	generate	VERB
admet-1513	366	5	from	from	ADP
admet-1513	366	6	the	the	DET
admet-1513	366	7	differentiated	differentiate	VERB
admet-1513	366	8	hepatoblasts	hepatoblast	NOUN
admet-1513	366	9	with	with	ADP
admet-1513	366	10	the	the	DET
admet-1513	366	11	addition	addition	NOUN
admet-1513	366	12	of	of	ADP
admet-1513	366	13	egf	egf	PROPN
admet-1513	367	1	[	[	X
admet-1513	367	2	152	152	NUM
admet-1513	367	3	]	]	PUNCT
admet-1513	367	4	.	.	PUNCT
admet-1513	368	1	these	these	DET
admet-1513	368	2	organoids	organoid	NOUN
admet-1513	368	3	contain	contain	VERB
admet-1513	368	4	both	both	DET
admet-1513	368	5	hepatocytes	hepatocyte	NOUN
admet-1513	368	6	and	and	CCONJ
admet-1513	368	7	cholangiocytes	cholangiocyte	NOUN
admet-1513	368	8	.	.	PUNCT
admet-1513	369	1	similarly	similarly	ADV
admet-1513	369	2	,	,	PUNCT
admet-1513	369	3	wu	wu	PROPN
admet-1513	369	4	and	and	CCONJ
admet-1513	369	5	colleagues	colleague	NOUN
admet-1513	370	1	[	[	X
admet-1513	370	2	153	153	NUM
admet-1513	370	3	]	]	PUNCT
admet-1513	370	4	also	also	ADV
admet-1513	370	5	generated	generate	VERB
admet-1513	370	6	a	a	DET
admet-1513	370	7	protocol	protocol	NOUN
admet-1513	370	8	through	through	ADP
admet-1513	370	9	which	which	PRON
admet-1513	370	10	the	the	DET
admet-1513	370	11	generated	generate	VERB
admet-1513	370	12	liver	liver	NOUN
admet-1513	370	13	organoids	organoid	NOUN
admet-1513	370	14	contain	contain	VERB
admet-1513	370	15	60	60	NUM
admet-1513	370	16	%	%	NOUN
admet-1513	370	17	albumin+	albumin+	PROPN
admet-1513	370	18	hepatocytes	hepatocyte	NOUN
admet-1513	370	19	and	and	CCONJ
admet-1513	370	20	about	about	ADV
admet-1513	370	21	30	30	NUM
admet-1513	370	22	%	%	NOUN
admet-1513	370	23	ck19	ck19	PROPN
admet-1513	370	24	+	+	PROPN
admet-1513	370	25	cholangiocytes	cholangiocyte	NOUN
admet-1513	370	26	.	.	PUNCT
admet-1513	371	1	recently	recently	ADV
admet-1513	371	2	,	,	PUNCT
admet-1513	371	3	a	a	DET
admet-1513	371	4	group	group	NOUN
admet-1513	371	5	of	of	ADP
admet-1513	371	6	researchers	researcher	NOUN
admet-1513	371	7	has	have	AUX
admet-1513	371	8	developed	develop	VERB
admet-1513	371	9	a	a	DET
admet-1513	371	10	robust	robust	ADJ
admet-1513	371	11	protocol	protocol	NOUN
admet-1513	371	12	for	for	ADP
admet-1513	371	13	the	the	DET
admet-1513	371	14	generation	generation	NOUN
admet-1513	371	15	of	of	ADP
admet-1513	371	16	liver	liver	NOUN
admet-1513	371	17	organoids	organoid	NOUN
admet-1513	371	18	containing	contain	VERB
admet-1513	371	19	hepatocytes	hepatocyte	NOUN
admet-1513	371	20	,	,	PUNCT
admet-1513	371	21	hscs	hsc	NOUN
admet-1513	371	22	,	,	PUNCT
admet-1513	371	23	kupffer	kupffer	NOUN
admet-1513	371	24	cells	cell	NOUN
admet-1513	371	25	,	,	PUNCT
admet-1513	371	26	and	and	CCONJ
admet-1513	371	27	cholangiocytes	cholangiocyte	VERB
admet-1513	371	28	from	from	ADP
admet-1513	371	29	hipsc	hipsc	NOUN
admet-1513	371	30	[	[	X
admet-1513	371	31	154	154	NUM
admet-1513	371	32	]	]	PUNCT
admet-1513	371	33	.	.	PUNCT
admet-1513	372	1	they	they	PRON
admet-1513	372	2	first	first	ADV
admet-1513	372	3	differentiated	differentiate	VERB
admet-1513	372	4	hpscs	hpsc	NOUN
admet-1513	372	5	to	to	ADP
admet-1513	372	6	foregut	foregut	ADJ
admet-1513	372	7	spheroids	spheroid	NOUN
admet-1513	372	8	liberated	liberate	VERB
admet-1513	372	9	from	from	ADP
admet-1513	372	10	the	the	DET
admet-1513	372	11	2d	2d	NUM
admet-1513	372	12	culture	culture	NOUN
admet-1513	372	13	and	and	CCONJ
admet-1513	372	14	embedded	embed	VERB
admet-1513	372	15	them	they	PRON
admet-1513	372	16	in	in	ADP
admet-1513	372	17	matrigel	matrigel	NOUN
admet-1513	372	18	.	.	PUNCT
admet-1513	373	1	the	the	DET
admet-1513	373	2	addition	addition	NOUN
admet-1513	373	3	of	of	ADP
admet-1513	373	4	retinoic	retinoic	PROPN
admet-1513	373	5	acid	acid	PROPN
admet-1513	373	6	helped	help	VERB
admet-1513	373	7	in	in	ADP
admet-1513	373	8	further	further	ADJ
admet-1513	373	9	differentiation	differentiation	NOUN
admet-1513	373	10	into	into	ADP
admet-1513	373	11	both	both	CCONJ
admet-1513	373	12	parenchymal	parenchymal	ADJ
admet-1513	373	13	and	and	CCONJ
admet-1513	373	14	non	non	ADJ
admet-1513	373	15	-	-	ADJ
admet-1513	373	16	parenchymal	parenchymal	ADJ
admet-1513	373	17	liver	liver	NOUN
admet-1513	373	18	cells	cell	NOUN
admet-1513	373	19	[	[	X
admet-1513	373	20	154	154	NUM
admet-1513	373	21	]	]	PUNCT
admet-1513	373	22	.	.	PUNCT
admet-1513	374	1	similarly	similarly	ADV
admet-1513	374	2	,	,	PUNCT
admet-1513	374	3	mun	mun	PROPN
admet-1513	374	4	and	and	CCONJ
admet-1513	374	5	colleagues	colleague	NOUN
admet-1513	375	1	[	[	X
admet-1513	375	2	147	147	NUM
admet-1513	375	3	]	]	PUNCT
admet-1513	375	4	developed	develop	VERB
admet-1513	375	5	a	a	DET
admet-1513	375	6	protocol	protocol	NOUN
admet-1513	375	7	for	for	ADP
admet-1513	375	8	the	the	DET
admet-1513	375	9	generation	generation	NOUN
admet-1513	375	10	of	of	ADP
admet-1513	375	11	liver	liver	NOUN
admet-1513	375	12	organoids	organoid	NOUN
admet-1513	375	13	.	.	PUNCT
admet-1513	376	1	they	they	PRON
admet-1513	376	2	demonstrated	demonstrate	VERB
admet-1513	376	3	that	that	SCONJ
admet-1513	376	4	their	their	PRON
admet-1513	376	5	protocol	protocol	NOUN
admet-1513	376	6	was	be	AUX
admet-1513	376	7	reproducible	reproducible	ADJ
admet-1513	376	8	and	and	CCONJ
admet-1513	376	9	took	take	VERB
admet-1513	376	10	relatively	relatively	ADV
admet-1513	376	11	less	less	ADJ
admet-1513	376	12	time	time	NOUN
admet-1513	376	13	to	to	PART
admet-1513	376	14	generate	generate	VERB
admet-1513	376	15	organoids	organoid	NOUN
admet-1513	376	16	.	.	PUNCT
admet-1513	377	1	the	the	DET
admet-1513	377	2	organoids	organoid	NOUN
admet-1513	377	3	are	be	AUX
admet-1513	377	4	scalable	scalable	ADJ
admet-1513	377	5	,	,	PUNCT
admet-1513	377	6	self	self	NOUN
admet-1513	377	7	-	-	PUNCT
admet-1513	377	8	renewed	renew	VERB
admet-1513	377	9	,	,	PUNCT
admet-1513	377	10	and	and	CCONJ
admet-1513	377	11	showed	show	VERB
admet-1513	377	12	rapid	rapid	ADJ
admet-1513	377	13	proliferation	proliferation	NOUN
admet-1513	377	14	and	and	CCONJ
admet-1513	377	15	maturation	maturation	NOUN
admet-1513	377	16	.	.	PUNCT
admet-1513	378	1	moreover	moreover	ADV
admet-1513	378	2	,	,	PUNCT
admet-1513	378	3	they	they	PRON
admet-1513	378	4	also	also	ADV
admet-1513	378	5	showed	show	VERB
admet-1513	378	6	liver	liver	ADJ
admet-1513	378	7	functional	functional	ADJ
admet-1513	378	8	properties	property	NOUN
admet-1513	378	9	after	after	ADP
admet-1513	378	10	20	20	NUM
admet-1513	378	11	passages	passage	NOUN
admet-1513	378	12	and	and	CCONJ
admet-1513	378	13	good	good	ADJ
admet-1513	378	14	viability	viability	NOUN
admet-1513	378	15	after	after	ADP
admet-1513	378	16	cryo	cryo	NOUN
admet-1513	378	17	-	-	PUNCT
admet-1513	378	18	preservation	preservation	NOUN
admet-1513	378	19	[	[	X
admet-1513	378	20	147	147	NUM
admet-1513	378	21	]	]	PUNCT
admet-1513	378	22	.	.	PUNCT
admet-1513	379	1	other	other	ADJ
admet-1513	379	2	than	than	ADP
admet-1513	379	3	organoids	organoid	NOUN
admet-1513	379	4	,	,	PUNCT
admet-1513	379	5	drug	drug	NOUN
admet-1513	379	6	screening	screening	NOUN
admet-1513	379	7	studies	study	NOUN
admet-1513	379	8	showed	show	VERB
admet-1513	379	9	that	that	SCONJ
admet-1513	379	10	liver	liver	NOUN
admet-1513	379	11	-	-	PUNCT
admet-1513	379	12	on	on	ADP
admet-1513	379	13	-	-	PUNCT
admet-1513	379	14	chip	chip	NOUN
admet-1513	379	15	or	or	CCONJ
admet-1513	379	16	liver	liver	NOUN
admet-1513	379	17	-	-	PUNCT
admet-1513	379	18	mps	mp	NOUN
admet-1513	379	19	demonstrated	demonstrate	VERB
admet-1513	379	20	significant	significant	ADJ
admet-1513	379	21	potential	potential	NOUN
admet-1513	379	22	for	for	ADP
admet-1513	379	23	drug	drug	NOUN
admet-1513	379	24	pks	pks	NOUN
admet-1513	379	25	and	and	CCONJ
admet-1513	379	26	toxicity	toxicity	NOUN
admet-1513	379	27	research	research	NOUN
admet-1513	380	1	[	[	X
admet-1513	380	2	155,156,157	155,156,157	NUM
admet-1513	380	3	]	]	PUNCT
admet-1513	380	4	.	.	PUNCT
admet-1513	381	1	in	in	ADP
admet-1513	381	2	liver	liver	NOUN
admet-1513	381	3	-	-	PUNCT
admet-1513	381	4	mps	mp	NOUN
admet-1513	381	5	,	,	PUNCT
admet-1513	381	6	cells	cell	NOUN
admet-1513	381	7	are	be	AUX
admet-1513	381	8	continuously	continuously	ADV
admet-1513	381	9	grown	grow	VERB
admet-1513	381	10	in	in	ADP
admet-1513	381	11	perfused	perfused	ADJ
admet-1513	381	12	chambers	chamber	NOUN
admet-1513	381	13	to	to	PART
admet-1513	381	14	achieve	achieve	VERB
admet-1513	381	15	in	in	ADP
admet-1513	381	16	vivo	vivo	ADJ
admet-1513	381	17	liver	liver	NOUN
admet-1513	381	18	physiological	physiological	ADJ
admet-1513	381	19	functions	function	NOUN
admet-1513	381	20	[	[	X
admet-1513	381	21	158	158	NUM
admet-1513	381	22	]	]	PUNCT
admet-1513	381	23	.	.	PUNCT
admet-1513	382	1	although	although	SCONJ
admet-1513	382	2	there	there	PRON
admet-1513	382	3	has	have	AUX
admet-1513	382	4	been	be	AUX
admet-1513	382	5	significant	significant	ADJ
admet-1513	382	6	progress	progress	NOUN
admet-1513	382	7	in	in	ADP
admet-1513	382	8	the	the	DET
admet-1513	382	9	development	development	NOUN
admet-1513	382	10	of	of	ADP
admet-1513	382	11	liver	liver	NOUN
admet-1513	382	12	-	-	PUNCT
admet-1513	382	13	mps	mp	NOUN
admet-1513	382	14	,	,	PUNCT
admet-1513	382	15	however	however	ADV
admet-1513	382	16	,	,	PUNCT
admet-1513	382	17	the	the	DET
admet-1513	382	18	majority	majority	NOUN
admet-1513	382	19	of	of	ADP
admet-1513	382	20	the	the	DET
admet-1513	382	21	researchers	researcher	NOUN
admet-1513	382	22	used	use	VERB
admet-1513	382	23	2d	2d	NUM
admet-1513	382	24	hepatocytes	hepatocyte	NOUN
admet-1513	382	25	for	for	ADP
admet-1513	382	26	developing	develop	VERB
admet-1513	382	27	liver	liver	NOUN
admet-1513	382	28	mps	mp	NOUN
admet-1513	382	29	.	.	PUNCT
admet-1513	383	1	a	a	DET
admet-1513	383	2	reliable	reliable	ADJ
admet-1513	383	3	3d	3d	NOUN
admet-1513	383	4	in	in	ADP
admet-1513	383	5	vitro	vitro	X
admet-1513	383	6	model	model	NOUN
admet-1513	383	7	with	with	ADP
admet-1513	383	8	a	a	DET
admet-1513	383	9	stable	stable	ADJ
admet-1513	383	10	phenotype	phenotype	NOUN
admet-1513	383	11	that	that	PRON
admet-1513	383	12	can	can	AUX
admet-1513	383	13	maintain	maintain	VERB
admet-1513	383	14	morphology	morphology	NOUN
admet-1513	383	15	,	,	PUNCT
admet-1513	383	16	viability	viability	NOUN
admet-1513	383	17	and	and	CCONJ
admet-1513	383	18	hepatocyte	hepatocyte	NOUN
admet-1513	383	19	-	-	PUNCT
admet-1513	383	20	specific	specific	ADJ
admet-1513	383	21	function	function	NOUN
admet-1513	383	22	for	for	ADP
admet-1513	383	23	a	a	DET
admet-1513	383	24	prolonged	prolonged	ADJ
admet-1513	383	25	period	period	NOUN
admet-1513	383	26	still	still	ADV
admet-1513	383	27	needs	need	VERB
admet-1513	383	28	to	to	PART
admet-1513	383	29	be	be	AUX
admet-1513	383	30	developed	develop	VERB
admet-1513	383	31	.	.	PUNCT
admet-1513	384	1	researchers	researcher	NOUN
admet-1513	384	2	are	be	AUX
admet-1513	384	3	putting	put	VERB
admet-1513	384	4	efforts	effort	NOUN
admet-1513	384	5	into	into	ADP
admet-1513	384	6	achieving	achieve	VERB
admet-1513	384	7	this	this	PRON
admet-1513	384	8	.	.	PUNCT
admet-1513	385	1	liver	liver	NOUN
admet-1513	385	2	-	-	PUNCT
admet-1513	385	3	mps	mp	NOUN
admet-1513	385	4	developed	develop	VERB
admet-1513	385	5	by	by	ADP
admet-1513	385	6	bavli	bavli	NOUN
admet-1513	385	7	and	and	CCONJ
admet-1513	385	8	colleagues	colleague	NOUN
admet-1513	385	9	[	[	X
admet-1513	385	10	159	159	NUM
admet-1513	385	11	]	]	PUNCT
admet-1513	385	12	reported	report	VERB
admet-1513	385	13	maintaining	maintain	VERB
admet-1513	385	14	stable	stable	ADJ
admet-1513	385	15	physiological	physiological	ADJ
admet-1513	385	16	conditions	condition	NOUN
admet-1513	385	17	for	for	ADP
admet-1513	385	18	one	one	NUM
admet-1513	385	19	month	month	NOUN
admet-1513	385	20	with	with	ADP
admet-1513	385	21	real	real	ADJ
admet-1513	385	22	-	-	PUNCT
admet-1513	385	23	time	time	NOUN
admet-1513	385	24	monitoring	monitoring	NOUN
admet-1513	385	25	of	of	ADP
admet-1513	385	26	mitochondrial	mitochondrial	ADJ
admet-1513	385	27	respiration	respiration	NOUN
admet-1513	385	28	.	.	PUNCT
admet-1513	386	1	they	they	PRON
admet-1513	386	2	also	also	ADV
admet-1513	386	3	measured	measure	VERB
admet-1513	386	4	the	the	DET
admet-1513	386	5	glucose	glucose	NOUN
admet-1513	386	6	and	and	CCONJ
admet-1513	386	7	lactate	lactate	NOUN
admet-1513	386	8	electrochemically	electrochemically	ADV
admet-1513	386	9	using	use	VERB
admet-1513	386	10	computer	computer	NOUN
admet-1513	386	11	controlled	control	VERB
admet-1513	386	12	microfluid	microfluid	NOUN
admet-1513	386	13	switchboard	switchboard	NOUN
admet-1513	386	14	.	.	PUNCT
admet-1513	387	1	jang	jang	PROPN
admet-1513	387	2	and	and	CCONJ
admet-1513	387	3	colleagues	colleague	NOUN
admet-1513	387	4	[	[	X
admet-1513	387	5	160	160	NUM
admet-1513	387	6	]	]	PUNCT
admet-1513	387	7	developed	develop	VERB
admet-1513	387	8	rat	rat	NOUN
admet-1513	387	9	,	,	PUNCT
admet-1513	387	10	dog	dog	NOUN
admet-1513	387	11	and	and	CCONJ
admet-1513	387	12	human	human	ADJ
admet-1513	387	13	liver	liver	NOUN
admet-1513	387	14	-	-	PUNCT
admet-1513	387	15	mps	mp	NOUN
admet-1513	387	16	models	model	NOUN
admet-1513	387	17	for	for	ADP
admet-1513	387	18	exploring	explore	VERB
admet-1513	387	19	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	387	20	safety	safety	NOUN
admet-1513	387	21	testing	testing	NOUN
admet-1513	387	22	,	,	PUNCT
admet-1513	387	23	drug	drug	NOUN
admet-1513	387	24	action	action	NOUN
admet-1513	387	25	mechanism	mechanism	NOUN
admet-1513	387	26	,	,	PUNCT
admet-1513	387	27	and	and	CCONJ
admet-1513	387	28	biomarker	biomarker	NOUN
admet-1513	387	29	identification	identification	NOUN
admet-1513	387	30	.	.	PUNCT
admet-1513	388	1	their	their	PRON
admet-1513	388	2	finding	finding	NOUN
admet-1513	388	3	implies	imply	VERB
admet-1513	388	4	that	that	SCONJ
admet-1513	388	5	species	species	NOUN
admet-1513	388	6	-	-	PUNCT
admet-1513	388	7	specific	specific	ADJ
admet-1513	388	8	liver	liver	NOUN
admet-1513	388	9	-	-	PUNCT
admet-1513	388	10	chip	chip	NOUN
admet-1513	388	11	can	can	AUX
admet-1513	388	12	be	be	AUX
admet-1513	388	13	used	use	VERB
admet-1513	388	14	to	to	PART
admet-1513	388	15	predict	predict	VERB
admet-1513	388	16	species	specie	NOUN
admet-1513	388	17	-	-	PUNCT
admet-1513	388	18	specific	specific	ADJ
admet-1513	388	19	hepatotoxicities	hepatotoxicitie	NOUN
admet-1513	388	20	and	and	CCONJ
admet-1513	388	21	are	be	AUX
admet-1513	388	22	further	far	ADV
admet-1513	388	23	helpful	helpful	ADJ
admet-1513	388	24	in	in	ADP
admet-1513	388	25	assessing	assess	VERB
admet-1513	388	26	the	the	DET
admet-1513	388	27	risk	risk	NOUN
admet-1513	388	28	of	of	ADP
admet-1513	388	29	drug	drug	NOUN
admet-1513	388	30	-	-	PUNCT
admet-1513	388	31	induced	induce	VERB
admet-1513	388	32	liver	liver	NOUN
admet-1513	388	33	toxicities	toxicity	NOUN
admet-1513	388	34	in	in	ADP
admet-1513	388	35	humans	human	NOUN
admet-1513	388	36	as	as	SCONJ
admet-1513	388	37	found	find	VERB
admet-1513	388	38	in	in	ADP
admet-1513	388	39	animal	animal	NOUN
admet-1513	388	40	studies	study	NOUN
admet-1513	388	41	.	.	PUNCT
admet-1513	389	1	these	these	DET
admet-1513	389	2	models	model	NOUN
admet-1513	389	3	may	may	AUX
admet-1513	389	4	also	also	ADV
admet-1513	389	5	be	be	AUX
admet-1513	389	6	utilized	utilize	VERB
admet-1513	389	7	to	to	PART
admet-1513	389	8	determine	determine	VERB
admet-1513	389	9	human	human	ADJ
admet-1513	389	10	hepatotoxicities	hepatotoxicitie	NOUN
admet-1513	389	11	and	and	CCONJ
admet-1513	389	12	mechanisms	mechanism	NOUN
admet-1513	389	13	of	of	ADP
admet-1513	389	14	action	action	NOUN
admet-1513	389	15	.	.	PUNCT
admet-1513	390	1	recently	recently	ADV
admet-1513	390	2	,	,	PUNCT
admet-1513	390	3	researchers	researcher	NOUN
admet-1513	390	4	developed	develop	VERB
admet-1513	390	5	a	a	DET
admet-1513	390	6	novel	novel	ADJ
admet-1513	390	7	liver	liver	NOUN
admet-1513	390	8	-	-	PUNCT
admet-1513	390	9	mps	mp	NOUN
admet-1513	390	10	model	model	NOUN
admet-1513	390	11	and	and	CCONJ
admet-1513	390	12	could	could	AUX
admet-1513	390	13	able	able	ADJ
admet-1513	390	14	to	to	PART
admet-1513	390	15	achieve	achieve	VERB
admet-1513	390	16	differentiation	differentiation	NOUN
admet-1513	390	17	of	of	ADP
admet-1513	390	18	hipsc	hipsc	NOUN
admet-1513	390	19	into	into	ADP
admet-1513	390	20	organoids	organoid	NOUN
admet-1513	390	21	inside	inside	ADP
admet-1513	390	22	the	the	DET
admet-1513	390	23	chip	chip	NOUN
admet-1513	390	24	[	[	X
admet-1513	390	25	161	161	NUM
admet-1513	390	26	]	]	PUNCT
admet-1513	390	27	.	.	PUNCT
admet-1513	391	1	these	these	DET
admet-1513	391	2	organoids	organoid	NOUN
admet-1513	391	3	were	be	AUX
admet-1513	391	4	characterized	characterize	VERB
admet-1513	391	5	by	by	ADP
admet-1513	391	6	both	both	DET
admet-1513	391	7	hepatocytes	hepatocyte	NOUN
admet-1513	391	8	and	and	CCONJ
admet-1513	391	9	cholangiocytes	cholangiocyte	NOUN
admet-1513	391	10	,	,	PUNCT
admet-1513	391	11	along	along	ADP
admet-1513	391	12	with	with	ADP
admet-1513	391	13	increased	increase	VERB
admet-1513	391	14	cell	cell	NOUN
admet-1513	391	15	viability	viability	NOUN
admet-1513	391	16	and	and	CCONJ
admet-1513	391	17	maturity	maturity	NOUN
admet-1513	391	18	.	.	PUNCT
admet-1513	392	1	moreover	moreover	ADV
admet-1513	392	2	,	,	PUNCT
admet-1513	392	3	the	the	DET
admet-1513	392	4	organoids	organoid	NOUN
admet-1513	392	5	generated	generate	VERB
admet-1513	392	6	in	in	ADP
admet-1513	392	7	this	this	DET
admet-1513	392	8	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	392	9	venkatesh	venkatesh	PROPN
admet-1513	392	10	chunduri	chunduri	PROPN
admet-1513	392	11	and	and	CCONJ
admet-1513	392	12	srinivas	srinivas	PROPN
admet-1513	392	13	maddi	maddi	PROPN
admet-1513	392	14	admet	admet	PROPN
admet-1513	392	15	&	&	CCONJ
admet-1513	392	16	dmpk	dmpk	PROPN
admet-1513	392	17	11(1	11(1	NUM
admet-1513	392	18	)	)	PUNCT
admet-1513	392	19	(	(	PUNCT
admet-1513	392	20	2023	2023	NUM
admet-1513	392	21	)	)	PUNCT
admet-1513	392	22	1	1	NUM
admet-1513	392	23	-	-	SYM
admet-1513	392	24	32	32	NUM
admet-1513	392	25	14	14	NUM
admet-1513	392	26	liver	liver	NOUN
admet-1513	392	27	-	-	PUNCT
admet-1513	392	28	mps	mp	NOUN
admet-1513	392	29	platform	platform	NOUN
admet-1513	392	30	have	have	AUX
admet-1513	392	31	shown	show	VERB
admet-1513	392	32	high	high	ADJ
admet-1513	392	33	cyp	cyp	ADJ
admet-1513	392	34	enzyme	enzyme	NOUN
admet-1513	392	35	expression	expression	NOUN
admet-1513	392	36	and	and	CCONJ
admet-1513	392	37	acetaminophen	acetaminophen	NOUN
admet-1513	392	38	-	-	PUNCT
admet-1513	392	39	mediated	mediate	VERB
admet-1513	392	40	dose	dose	NOUN
admet-1513	392	41	-	-	PUNCT
admet-1513	392	42	and	and	CCONJ
admet-1513	392	43	timedependent	timedependent	NOUN
admet-1513	392	44	toxicity	toxicity	NOUN
admet-1513	392	45	responses	response	NOUN
admet-1513	392	46	.	.	PUNCT
admet-1513	393	1	all	all	DET
admet-1513	393	2	these	these	DET
admet-1513	393	3	results	result	NOUN
admet-1513	393	4	suggest	suggest	VERB
admet-1513	393	5	that	that	SCONJ
admet-1513	393	6	mps	mps	PROPN
admet-1513	393	7	technology	technology	NOUN
admet-1513	393	8	constitutes	constitute	VERB
admet-1513	393	9	a	a	DET
admet-1513	393	10	valid	valid	ADJ
admet-1513	393	11	platform	platform	NOUN
admet-1513	393	12	for	for	ADP
admet-1513	393	13	drug	drug	NOUN
admet-1513	393	14	testing	testing	NOUN
admet-1513	393	15	.	.	PUNCT
admet-1513	394	1	organoid	organoid	PROPN
admet-1513	394	2	models	model	NOUN
admet-1513	394	3	to	to	PART
admet-1513	394	4	evaluate	evaluate	VERB
admet-1513	394	5	drug	drug	NOUN
admet-1513	394	6	toxicity	toxicity	NOUN
admet-1513	394	7	drug	drug	NOUN
admet-1513	394	8	-	-	PUNCT
admet-1513	394	9	induced	induce	VERB
admet-1513	394	10	toxicity	toxicity	NOUN
admet-1513	394	11	during	during	ADP
admet-1513	394	12	the	the	DET
admet-1513	394	13	drug	drug	NOUN
admet-1513	394	14	discovery	discovery	NOUN
admet-1513	394	15	process	process	NOUN
admet-1513	394	16	may	may	AUX
admet-1513	394	17	lead	lead	VERB
admet-1513	394	18	to	to	ADP
admet-1513	394	19	the	the	DET
admet-1513	394	20	discontinuation	discontinuation	NOUN
admet-1513	394	21	of	of	ADP
admet-1513	394	22	research	research	NOUN
admet-1513	394	23	programs	program	NOUN
admet-1513	394	24	[	[	X
admet-1513	394	25	162	162	NUM
admet-1513	394	26	]	]	PUNCT
admet-1513	394	27	.	.	PUNCT
admet-1513	395	1	drug	drug	NOUN
admet-1513	395	2	-	-	PUNCT
admet-1513	395	3	induced	induce	VERB
admet-1513	395	4	toxicity	toxicity	NOUN
admet-1513	395	5	can	can	AUX
admet-1513	395	6	occur	occur	VERB
admet-1513	395	7	in	in	ADP
admet-1513	395	8	various	various	ADJ
admet-1513	395	9	organs	organ	NOUN
admet-1513	395	10	and	and	CCONJ
admet-1513	395	11	tissues	tissue	NOUN
admet-1513	395	12	in	in	ADP
admet-1513	395	13	the	the	DET
admet-1513	395	14	body	body	NOUN
admet-1513	395	15	and	and	CCONJ
admet-1513	395	16	causes	cause	VERB
admet-1513	395	17	acute	acute	ADJ
admet-1513	395	18	injury	injury	NOUN
admet-1513	396	1	[	[	X
admet-1513	396	2	163	163	NUM
admet-1513	396	3	]	]	PUNCT
admet-1513	396	4	.	.	PUNCT
admet-1513	397	1	although	although	SCONJ
admet-1513	397	2	animal	animal	NOUN
admet-1513	397	3	studies	study	NOUN
admet-1513	397	4	are	be	AUX
admet-1513	397	5	being	be	AUX
admet-1513	397	6	conducted	conduct	VERB
admet-1513	397	7	to	to	PART
admet-1513	397	8	predict	predict	VERB
admet-1513	397	9	the	the	DET
admet-1513	397	10	risk	risk	NOUN
admet-1513	397	11	of	of	ADP
admet-1513	397	12	drug	drug	NOUN
admet-1513	397	13	-	-	PUNCT
admet-1513	397	14	induced	induce	VERB
admet-1513	397	15	toxicity	toxicity	NOUN
admet-1513	397	16	,	,	PUNCT
admet-1513	397	17	because	because	SCONJ
admet-1513	397	18	of	of	ADP
admet-1513	397	19	species	species	NOUN
admet-1513	397	20	variation	variation	NOUN
admet-1513	397	21	,	,	PUNCT
admet-1513	397	22	only	only	ADV
admet-1513	397	23	40	40	NUM
admet-1513	397	24	-	-	SYM
admet-1513	397	25	50	50	NUM
admet-1513	397	26	%	%	NOUN
admet-1513	397	27	toxicity	toxicity	NOUN
admet-1513	397	28	can	can	AUX
admet-1513	397	29	be	be	AUX
admet-1513	397	30	predicted	predict	VERB
admet-1513	397	31	[	[	X
admet-1513	397	32	164	164	NUM
admet-1513	397	33	]	]	PUNCT
admet-1513	397	34	.	.	PUNCT
admet-1513	398	1	consequently	consequently	ADV
admet-1513	398	2	,	,	PUNCT
admet-1513	398	3	many	many	ADJ
admet-1513	398	4	researchers	researcher	NOUN
admet-1513	398	5	have	have	AUX
admet-1513	398	6	developed	develop	VERB
admet-1513	398	7	in	in	ADP
admet-1513	398	8	vitro	vitro	X
admet-1513	398	9	2d	2d	NUM
admet-1513	398	10	cell	cell	NOUN
admet-1513	398	11	-	-	PUNCT
admet-1513	398	12	based	base	VERB
admet-1513	398	13	assays	assay	NOUN
admet-1513	398	14	to	to	PART
admet-1513	398	15	predict	predict	VERB
admet-1513	398	16	drug	drug	NOUN
admet-1513	398	17	-	-	PUNCT
admet-1513	398	18	induced	induce	VERB
admet-1513	398	19	toxicity	toxicity	NOUN
admet-1513	398	20	.	.	PUNCT
admet-1513	399	1	however	however	ADV
admet-1513	399	2	,	,	PUNCT
admet-1513	399	3	these	these	DET
admet-1513	399	4	assays	assay	NOUN
admet-1513	399	5	utilize	utilize	VERB
admet-1513	399	6	singlecell	singlecell	NOUN
admet-1513	399	7	types	type	NOUN
admet-1513	399	8	and	and	CCONJ
admet-1513	399	9	can	can	AUX
admet-1513	399	10	not	not	PART
admet-1513	399	11	recapitulate	recapitulate	VERB
admet-1513	399	12	the	the	DET
admet-1513	399	13	physiological	physiological	ADJ
admet-1513	399	14	organ	organ	NOUN
admet-1513	399	15	function	function	NOUN
admet-1513	399	16	due	due	ADP
admet-1513	399	17	to	to	ADP
admet-1513	399	18	the	the	DET
admet-1513	399	19	absence	absence	NOUN
admet-1513	399	20	of	of	ADP
admet-1513	399	21	different	different	ADJ
admet-1513	399	22	cell	cell	NOUN
admet-1513	399	23	types	type	NOUN
admet-1513	399	24	.	.	PUNCT
admet-1513	400	1	the	the	DET
admet-1513	400	2	development	development	NOUN
admet-1513	400	3	of	of	ADP
admet-1513	400	4	organoids	organoid	NOUN
admet-1513	400	5	has	have	AUX
admet-1513	400	6	shown	show	VERB
admet-1513	400	7	great	great	ADJ
admet-1513	400	8	promise	promise	NOUN
admet-1513	400	9	for	for	ADP
admet-1513	400	10	studying	study	VERB
admet-1513	400	11	drug	drug	NOUN
admet-1513	400	12	toxicity	toxicity	NOUN
admet-1513	400	13	evaluations	evaluation	NOUN
admet-1513	400	14	as	as	SCONJ
admet-1513	400	15	they	they	PRON
admet-1513	400	16	are	be	AUX
admet-1513	400	17	more	more	ADV
admet-1513	400	18	anatomically	anatomically	ADV
admet-1513	400	19	and	and	CCONJ
admet-1513	400	20	functionally	functionally	ADV
admet-1513	400	21	close	close	ADJ
admet-1513	400	22	to	to	ADP
admet-1513	400	23	the	the	DET
admet-1513	400	24	organs	organ	NOUN
admet-1513	400	25	in	in	ADP
admet-1513	400	26	the	the	DET
admet-1513	400	27	living	live	VERB
admet-1513	400	28	body	body	NOUN
admet-1513	400	29	[	[	X
admet-1513	400	30	165	165	NUM
admet-1513	400	31	]	]	PUNCT
admet-1513	400	32	.	.	PUNCT
admet-1513	401	1	the	the	DET
admet-1513	401	2	most	most	ADV
admet-1513	401	3	common	common	ADJ
admet-1513	401	4	drug	drug	NOUN
admet-1513	401	5	-	-	PUNCT
admet-1513	401	6	induced	induce	VERB
admet-1513	401	7	toxicity	toxicity	NOUN
admet-1513	401	8	is	be	AUX
admet-1513	401	9	dili	dili	NOUN
admet-1513	401	10	,	,	PUNCT
admet-1513	401	11	as	as	SCONJ
admet-1513	401	12	the	the	DET
admet-1513	401	13	liver	liver	NOUN
admet-1513	401	14	is	be	AUX
admet-1513	401	15	the	the	DET
admet-1513	401	16	first	first	ADJ
admet-1513	401	17	-	-	PUNCT
admet-1513	401	18	pass	pass	VERB
admet-1513	401	19	organ	organ	NOUN
admet-1513	401	20	and	and	CCONJ
admet-1513	401	21	where	where	SCONJ
admet-1513	401	22	most	most	ADJ
admet-1513	401	23	of	of	ADP
admet-1513	401	24	the	the	DET
admet-1513	401	25	drug	drug	NOUN
admet-1513	401	26	metabolism	metabolism	NOUN
admet-1513	401	27	occurs	occur	VERB
admet-1513	401	28	.	.	PUNCT
admet-1513	402	1	to	to	ADP
admet-1513	402	2	date	date	NOUN
admet-1513	402	3	,	,	PUNCT
admet-1513	402	4	dili	dili	PROPN
admet-1513	402	5	has	have	AUX
admet-1513	402	6	been	be	AUX
admet-1513	402	7	evaluated	evaluate	VERB
admet-1513	402	8	using	use	VERB
admet-1513	402	9	phh	phh	PROPN
admet-1513	402	10	or	or	CCONJ
admet-1513	402	11	hepatocytes	hepatocyte	NOUN
admet-1513	402	12	derived	derive	VERB
admet-1513	402	13	from	from	ADP
admet-1513	402	14	hipsc	hipsc	NOUN
admet-1513	402	15	.	.	PUNCT
admet-1513	403	1	but	but	CCONJ
admet-1513	403	2	these	these	DET
admet-1513	403	3	assays	assay	NOUN
admet-1513	403	4	could	could	AUX
admet-1513	403	5	n’t	not	PART
admet-1513	403	6	recapitulate	recapitulate	VERB
admet-1513	403	7	physiological	physiological	ADJ
admet-1513	403	8	liver	liver	NOUN
admet-1513	403	9	function	function	NOUN
admet-1513	403	10	since	since	SCONJ
admet-1513	403	11	,	,	PUNCT
admet-1513	403	12	in	in	ADP
admet-1513	403	13	addition	addition	NOUN
admet-1513	403	14	to	to	ADP
admet-1513	403	15	hepatocytes	hepatocytes	PROPN
admet-1513	403	16	,	,	PUNCT
admet-1513	403	17	the	the	DET
admet-1513	403	18	liver	liver	NOUN
admet-1513	403	19	is	be	AUX
admet-1513	403	20	also	also	ADV
admet-1513	403	21	composed	compose	VERB
admet-1513	403	22	of	of	ADP
admet-1513	403	23	several	several	ADJ
admet-1513	403	24	other	other	ADJ
admet-1513	403	25	cell	cell	NOUN
admet-1513	403	26	types	type	NOUN
admet-1513	403	27	such	such	ADJ
admet-1513	403	28	as	as	ADP
admet-1513	403	29	cholangiocytes	cholangiocyte	NOUN
admet-1513	403	30	,	,	PUNCT
admet-1513	403	31	stellate	stellate	ADJ
admet-1513	403	32	cells	cell	NOUN
admet-1513	403	33	,	,	PUNCT
admet-1513	403	34	kupffer	kupffer	NOUN
admet-1513	403	35	cells	cell	NOUN
admet-1513	403	36	,	,	PUNCT
admet-1513	403	37	and	and	CCONJ
admet-1513	403	38	lsecs	lsec	NOUN
admet-1513	403	39	.	.	PUNCT
admet-1513	404	1	to	to	PART
admet-1513	404	2	overcome	overcome	VERB
admet-1513	404	3	this	this	PRON
admet-1513	404	4	,	,	PUNCT
admet-1513	404	5	researchers	researcher	NOUN
admet-1513	404	6	succeeded	succeed	VERB
admet-1513	404	7	in	in	ADP
admet-1513	404	8	developing	develop	VERB
admet-1513	404	9	liver	liver	NOUN
admet-1513	404	10	organoids	organoid	NOUN
admet-1513	404	11	consisting	consist	VERB
admet-1513	404	12	of	of	ADP
admet-1513	404	13	a	a	DET
admet-1513	404	14	more	more	ADV
admet-1513	404	15	physiological	physiological	ADJ
admet-1513	404	16	similar	similar	ADJ
admet-1513	404	17	in	in	ADP
admet-1513	404	18	vitro	vitro	X
admet-1513	404	19	hepatic	hepatic	ADJ
admet-1513	404	20	model	model	NOUN
admet-1513	404	21	and	and	CCONJ
admet-1513	404	22	performed	perform	VERB
admet-1513	404	23	toxicity	toxicity	NOUN
admet-1513	404	24	assessments	assessment	NOUN
admet-1513	404	25	.	.	PUNCT
admet-1513	405	1	liver	liver	NOUN
admet-1513	405	2	organoids	organoid	NOUN
admet-1513	405	3	developed	develop	VERB
admet-1513	405	4	by	by	ADP
admet-1513	405	5	sgodda	sgodda	NOUN
admet-1513	405	6	and	and	CCONJ
admet-1513	405	7	colleagues	colleague	NOUN
admet-1513	406	1	[	[	X
admet-1513	406	2	166	166	NUM
admet-1513	406	3	]	]	PUNCT
admet-1513	406	4	from	from	ADP
admet-1513	406	5	embryonic	embryonic	ADJ
admet-1513	406	6	stem	stem	NOUN
admet-1513	406	7	cells	cell	NOUN
admet-1513	406	8	(	(	PUNCT
admet-1513	406	9	esc	esc	NOUN
admet-1513	406	10	)	)	PUNCT
admet-1513	406	11	were	be	AUX
admet-1513	406	12	more	more	ADV
admet-1513	406	13	sensitive	sensitive	ADJ
admet-1513	406	14	to	to	ADP
admet-1513	406	15	acetaminophen	acetaminophen	NOUN
admet-1513	406	16	-	-	PUNCT
admet-1513	406	17	induced	induce	VERB
admet-1513	406	18	toxicity	toxicity	NOUN
admet-1513	406	19	than	than	ADP
admet-1513	406	20	2d	2d	NUM
admet-1513	406	21	cultured	cultured	ADJ
admet-1513	406	22	esc	esc	NOUN
admet-1513	406	23	-	-	PUNCT
admet-1513	406	24	derived	derive	VERB
admet-1513	406	25	hepatic	hepatic	ADJ
admet-1513	406	26	cells	cell	NOUN
admet-1513	406	27	.	.	PUNCT
admet-1513	407	1	forsythe	forsythe	PROPN
admet-1513	407	2	and	and	CCONJ
admet-1513	407	3	colleagues	colleague	NOUN
admet-1513	407	4	[	[	X
admet-1513	407	5	167	167	NUM
admet-1513	407	6	]	]	PUNCT
admet-1513	407	7	generated	generate	VERB
admet-1513	407	8	liver	liver	NOUN
admet-1513	407	9	organoids	organoid	NOUN
admet-1513	407	10	composed	compose	VERB
admet-1513	407	11	of	of	ADP
admet-1513	407	12	80	80	NUM
admet-1513	407	13	%	%	NOUN
admet-1513	407	14	hepatocytes	hepatocyte	NOUN
admet-1513	407	15	,	,	PUNCT
admet-1513	407	16	10	10	NUM
admet-1513	407	17	%	%	NOUN
admet-1513	407	18	hepatic	hepatic	ADJ
admet-1513	407	19	stellate	stellate	ADJ
admet-1513	407	20	cells	cell	NOUN
admet-1513	407	21	and	and	CCONJ
admet-1513	407	22	10	10	NUM
admet-1513	407	23	%	%	NOUN
admet-1513	407	24	kupffer	kupffer	NOUN
admet-1513	407	25	cells	cell	NOUN
admet-1513	407	26	and	and	CCONJ
admet-1513	407	27	evaluated	evaluate	VERB
admet-1513	407	28	four	four	NUM
admet-1513	407	29	environmental	environmental	ADJ
admet-1513	407	30	heavy	heavy	ADJ
admet-1513	407	31	metals	metal	NOUN
admet-1513	407	32	.	.	PUNCT
admet-1513	408	1	they	they	PRON
admet-1513	408	2	observed	observe	VERB
admet-1513	408	3	dose	dose	NOUN
admet-1513	408	4	-	-	PUNCT
admet-1513	408	5	dependent	dependent	ADJ
admet-1513	408	6	toxicity	toxicity	NOUN
admet-1513	408	7	and	and	CCONJ
admet-1513	408	8	demonstrated	demonstrate	VERB
admet-1513	408	9	the	the	DET
admet-1513	408	10	use	use	NOUN
admet-1513	408	11	of	of	ADP
admet-1513	408	12	3d	3d	NUM
admet-1513	408	13	organoids	organoid	NOUN
admet-1513	408	14	in	in	ADP
admet-1513	408	15	toxicity	toxicity	NOUN
admet-1513	408	16	assessments	assessment	NOUN
admet-1513	408	17	.	.	PUNCT
admet-1513	409	1	similarly	similarly	ADV
admet-1513	409	2	,	,	PUNCT
admet-1513	409	3	a	a	DET
admet-1513	409	4	comparative	comparative	ADJ
admet-1513	409	5	assessment	assessment	NOUN
admet-1513	409	6	of	of	ADP
admet-1513	409	7	three	three	NUM
admet-1513	409	8	marketed	market	VERB
admet-1513	409	9	phospholipidosis	phospholipidosis	NOUN
admet-1513	409	10	drugs	drug	NOUN
admet-1513	409	11	on	on	ADP
admet-1513	409	12	2d	2d	NUM
admet-1513	409	13	hepg2	hepg2	NOUN
admet-1513	409	14	cells	cell	NOUN
admet-1513	409	15	and	and	CCONJ
admet-1513	409	16	3d	3d	NUM
admet-1513	409	17	liver	liver	NOUN
admet-1513	409	18	organoids	organoid	NOUN
admet-1513	409	19	showed	show	VERB
admet-1513	409	20	that	that	SCONJ
admet-1513	409	21	the	the	DET
admet-1513	409	22	organoids	organoid	NOUN
admet-1513	409	23	are	be	AUX
admet-1513	409	24	more	more	ADV
admet-1513	409	25	sensitive	sensitive	ADJ
admet-1513	409	26	to	to	ADP
admet-1513	409	27	druginduced	druginduced	ADJ
admet-1513	409	28	phospholipidosis	phospholipidosis	NOUN
admet-1513	409	29	[	[	X
admet-1513	409	30	168	168	NUM
admet-1513	409	31	]	]	PUNCT
admet-1513	409	32	.	.	PUNCT
admet-1513	410	1	recently	recently	ADV
admet-1513	410	2	,	,	PUNCT
admet-1513	410	3	shinozawa	shinozawa	PROPN
admet-1513	410	4	and	and	CCONJ
admet-1513	410	5	colleagues	colleague	NOUN
admet-1513	410	6	[	[	X
admet-1513	410	7	169	169	NUM
admet-1513	410	8	]	]	PUNCT
admet-1513	410	9	evaluated	evaluate	VERB
admet-1513	410	10	high	high	ADJ
admet-1513	410	11	throughput	throughput	NOUN
admet-1513	410	12	toxicity	toxicity	NOUN
admet-1513	410	13	screening	screening	NOUN
admet-1513	410	14	of	of	ADP
admet-1513	410	15	238	238	NUM
admet-1513	410	16	compounds	compound	NOUN
admet-1513	410	17	,	,	PUNCT
admet-1513	410	18	which	which	PRON
admet-1513	410	19	include	include	VERB
admet-1513	410	20	206	206	NUM
admet-1513	410	21	dili	dili	PROPN
admet-1513	410	22	compounds	compound	NOUN
admet-1513	410	23	using	use	VERB
admet-1513	410	24	bile	bile	NOUN
admet-1513	410	25	acid	acid	NOUN
admet-1513	410	26	transport	transport	NOUN
admet-1513	410	27	activity	activity	NOUN
admet-1513	410	28	and	and	CCONJ
admet-1513	410	29	cell	cell	NOUN
admet-1513	410	30	viability	viability	NOUN
admet-1513	410	31	assay	assay	VERB
admet-1513	410	32	.	.	PUNCT
admet-1513	411	1	the	the	DET
admet-1513	411	2	results	result	NOUN
admet-1513	411	3	showed	show	VERB
admet-1513	411	4	88.7	88.7	NUM
admet-1513	411	5	%	%	NOUN
admet-1513	411	6	sensitivity	sensitivity	NOUN
admet-1513	411	7	and	and	CCONJ
admet-1513	411	8	88.9	88.9	NUM
admet-1513	411	9	%	%	NOUN
admet-1513	411	10	specificity	specificity	NOUN
admet-1513	411	11	.	.	PUNCT
admet-1513	412	1	they	they	PRON
admet-1513	412	2	also	also	ADV
admet-1513	412	3	demonstrated	demonstrate	VERB
admet-1513	412	4	that	that	SCONJ
admet-1513	412	5	cyp2c9	cyp2c9	NOUN
admet-1513	412	6	*	*	ADJ
admet-1513	412	7	2	2	NUM
admet-1513	412	8	hlo	hlo	NOUN
admet-1513	412	9	is	be	AUX
admet-1513	412	10	involved	involve	VERB
admet-1513	412	11	in	in	ADP
admet-1513	412	12	bosentan	bosentan	ADV
admet-1513	412	13	-	-	PUNCT
admet-1513	412	14	induced	induce	VERB
admet-1513	412	15	cholestasis	cholestasis	NOUN
admet-1513	412	16	,	,	PUNCT
admet-1513	412	17	suggesting	suggest	VERB
admet-1513	412	18	that	that	SCONJ
admet-1513	412	19	by	by	ADP
admet-1513	412	20	employing	employ	VERB
admet-1513	412	21	liver	liver	NOUN
admet-1513	412	22	organoids	organoid	NOUN
admet-1513	412	23	,	,	PUNCT
admet-1513	412	24	various	various	ADJ
admet-1513	412	25	susceptibilities	susceptibility	NOUN
admet-1513	412	26	dependent	dependent	ADJ
admet-1513	412	27	on	on	ADP
admet-1513	412	28	the	the	DET
admet-1513	412	29	polymorphism	polymorphism	NOUN
admet-1513	412	30	can	can	AUX
admet-1513	412	31	be	be	AUX
admet-1513	412	32	obtained	obtain	VERB
admet-1513	412	33	.	.	PUNCT
admet-1513	412	34	drug	drug	NOUN
admet-1513	412	35	-	-	PUNCT
admet-1513	412	36	induced	induce	VERB
admet-1513	412	37	cardiotoxicity	cardiotoxicity	NOUN
admet-1513	412	38	(	(	PUNCT
admet-1513	412	39	dict	dict	NOUN
admet-1513	412	40	)	)	PUNCT
admet-1513	412	41	is	be	AUX
admet-1513	412	42	also	also	ADV
admet-1513	412	43	one	one	NUM
admet-1513	412	44	of	of	ADP
admet-1513	412	45	the	the	DET
admet-1513	412	46	major	major	ADJ
admet-1513	412	47	causes	cause	NOUN
admet-1513	412	48	of	of	ADP
admet-1513	412	49	attrition	attrition	NOUN
admet-1513	412	50	during	during	ADP
admet-1513	412	51	the	the	DET
admet-1513	412	52	drug	drug	NOUN
admet-1513	412	53	development	development	NOUN
admet-1513	412	54	process	process	NOUN
admet-1513	412	55	[	[	X
admet-1513	412	56	170	170	NUM
admet-1513	412	57	]	]	PUNCT
admet-1513	412	58	.	.	PUNCT
admet-1513	413	1	many	many	ADJ
admet-1513	413	2	drugs	drug	NOUN
admet-1513	413	3	have	have	AUX
admet-1513	413	4	been	be	AUX
admet-1513	413	5	reported	report	VERB
admet-1513	413	6	to	to	PART
admet-1513	413	7	cause	cause	VERB
admet-1513	413	8	prolonged	prolonged	ADJ
admet-1513	413	9	qt	qt	NOUN
admet-1513	413	10	and	and	CCONJ
admet-1513	413	11	ventricular	ventricular	ADJ
admet-1513	413	12	arrhythmia	arrhythmia	NOUN
admet-1513	413	13	[	[	X
admet-1513	413	14	171	171	NUM
admet-1513	413	15	]	]	PUNCT
admet-1513	413	16	.	.	PUNCT
admet-1513	414	1	moreover	moreover	ADV
admet-1513	414	2	,	,	PUNCT
admet-1513	414	3	most	most	ADJ
admet-1513	414	4	cancer	cancer	NOUN
admet-1513	414	5	-	-	PUNCT
admet-1513	414	6	related	relate	VERB
admet-1513	414	7	drugs	drug	NOUN
admet-1513	414	8	are	be	AUX
admet-1513	414	9	reported	report	VERB
admet-1513	414	10	to	to	PART
admet-1513	414	11	cause	cause	VERB
admet-1513	414	12	a	a	DET
admet-1513	414	13	reduction	reduction	NOUN
admet-1513	414	14	in	in	ADP
admet-1513	414	15	the	the	DET
admet-1513	414	16	left	left	ADJ
admet-1513	414	17	ventricular	ventricular	ADJ
admet-1513	414	18	ejection	ejection	NOUN
admet-1513	414	19	fraction	fraction	NOUN
admet-1513	414	20	(	(	PUNCT
admet-1513	414	21	lvef	lvef	NOUN
admet-1513	414	22	)	)	PUNCT
admet-1513	414	23	and	and	CCONJ
admet-1513	414	24	chronic	chronic	ADJ
admet-1513	414	25	heart	heart	NOUN
admet-1513	414	26	failure	failure	NOUN
admet-1513	414	27	upon	upon	SCONJ
admet-1513	414	28	long	long	ADJ
admet-1513	414	29	-	-	PUNCT
admet-1513	414	30	term	term	NOUN
admet-1513	414	31	medication	medication	NOUN
admet-1513	414	32	[	[	X
admet-1513	414	33	172	172	NUM
admet-1513	414	34	]	]	PUNCT
admet-1513	414	35	.	.	PUNCT
admet-1513	415	1	to	to	PART
admet-1513	415	2	assess	assess	VERB
admet-1513	415	3	the	the	DET
admet-1513	415	4	dict	dict	PROPN
admet-1513	415	5	,	,	PUNCT
admet-1513	415	6	ecg	ecg	PROPN
admet-1513	415	7	is	be	AUX
admet-1513	415	8	used	use	VERB
admet-1513	415	9	to	to	PART
admet-1513	415	10	monitor	monitor	VERB
admet-1513	415	11	the	the	DET
admet-1513	415	12	cardiac	cardiac	ADJ
admet-1513	415	13	functions	function	NOUN
admet-1513	415	14	during	during	ADP
admet-1513	415	15	the	the	DET
admet-1513	415	16	pre	pre	ADJ
admet-1513	415	17	-	-	ADJ
admet-1513	415	18	clinical	clinical	ADJ
admet-1513	415	19	trials	trial	NOUN
admet-1513	415	20	in	in	ADP
admet-1513	415	21	both	both	DET
admet-1513	415	22	rodents	rodent	NOUN
admet-1513	415	23	and	and	CCONJ
admet-1513	415	24	large	large	ADJ
admet-1513	415	25	animals	animal	NOUN
admet-1513	415	26	.	.	PUNCT
admet-1513	416	1	to	to	PART
admet-1513	416	2	reduce	reduce	VERB
admet-1513	416	3	animal	animal	NOUN
admet-1513	416	4	usage	usage	NOUN
admet-1513	416	5	,	,	PUNCT
admet-1513	416	6	preliminary	preliminary	ADJ
admet-1513	416	7	in	in	ADP
admet-1513	416	8	vitro	vitro	X
admet-1513	416	9	assays	assay	NOUN
admet-1513	416	10	have	have	AUX
admet-1513	416	11	been	be	AUX
admet-1513	416	12	developed	develop	VERB
admet-1513	416	13	,	,	PUNCT
admet-1513	416	14	such	such	ADJ
admet-1513	416	15	as	as	ADP
admet-1513	416	16	binding	bind	VERB
admet-1513	416	17	assay	assay	NOUN
admet-1513	416	18	in	in	ADP
admet-1513	416	19	hek293	hek293	PROPN
admet-1513	416	20	cells	cell	NOUN
admet-1513	416	21	that	that	PRON
admet-1513	416	22	express	express	VERB
admet-1513	416	23	human	human	ADJ
admet-1513	416	24	ether	ether	NOUN
admet-1513	416	25	-	-	PUNCT
admet-1513	416	26	agogo	agogo	NOUN
admet-1513	416	27	related	relate	VERB
admet-1513	416	28	gene	gene	NOUN
admet-1513	416	29	(	(	PUNCT
admet-1513	416	30	herg	herg	PROPN
admet-1513	416	31	)	)	PUNCT
admet-1513	416	32	k+	k+	NOUN
admet-1513	416	33	channels	channel	NOUN
admet-1513	416	34	[	[	X
admet-1513	416	35	173	173	NUM
admet-1513	416	36	]	]	X
admet-1513	416	37	,	,	PUNCT
admet-1513	416	38	which	which	PRON
admet-1513	416	39	has	have	AUX
admet-1513	416	40	been	be	AUX
admet-1513	416	41	widely	widely	ADV
admet-1513	416	42	used	use	VERB
admet-1513	416	43	to	to	PART
admet-1513	416	44	identify	identify	VERB
admet-1513	416	45	compounds	compound	NOUN
admet-1513	416	46	with	with	ADP
admet-1513	416	47	high	high	ADJ
admet-1513	416	48	qt	qt	NOUN
admet-1513	416	49	.	.	PUNCT
admet-1513	417	1	recent	recent	ADJ
admet-1513	417	2	advances	advance	NOUN
admet-1513	417	3	in	in	ADP
admet-1513	417	4	ipsc	ipsc	NOUN
admet-1513	417	5	-	-	PUNCT
admet-1513	417	6	derived	derive	VERB
admet-1513	417	7	cardiomyocytes	cardiomyocyte	NOUN
admet-1513	417	8	[	[	X
admet-1513	417	9	cms	cms	NOUN
admet-1513	417	10	]	]	PUNCT
admet-1513	417	11	have	have	AUX
admet-1513	417	12	also	also	ADV
admet-1513	417	13	become	become	VERB
admet-1513	417	14	increasingly	increasingly	ADV
admet-1513	417	15	utilized	utilize	VERB
admet-1513	417	16	tools	tool	NOUN
admet-1513	417	17	to	to	PART
admet-1513	417	18	predict	predict	VERB
admet-1513	417	19	drug	drug	NOUN
admet-1513	417	20	-	-	PUNCT
admet-1513	417	21	induced	induce	VERB
admet-1513	417	22	qt	qt	NOUN
admet-1513	417	23	and	and	CCONJ
admet-1513	417	24	arrhythmia	arrhythmia	VERB
admet-1513	417	25	[	[	X
admet-1513	417	26	174	174	NUM
admet-1513	417	27	-	-	SYM
admet-1513	417	28	177	177	NUM
admet-1513	417	29	]	]	PUNCT
admet-1513	417	30	.	.	PUNCT
admet-1513	418	1	however	however	ADV
admet-1513	418	2	,	,	PUNCT
admet-1513	418	3	these	these	DET
admet-1513	418	4	assays	assay	NOUN
admet-1513	418	5	are	be	AUX
admet-1513	418	6	only	only	ADV
admet-1513	418	7	specific	specific	ADJ
admet-1513	418	8	to	to	ADP
admet-1513	418	9	cms	cms	NOUN
admet-1513	418	10	,	,	PUNCT
admet-1513	418	11	but	but	CCONJ
admet-1513	418	12	the	the	DET
admet-1513	418	13	role	role	NOUN
admet-1513	418	14	of	of	ADP
admet-1513	418	15	non	non	ADJ
admet-1513	418	16	-	-	NOUN
admet-1513	418	17	cms	cms	ADJ
admet-1513	418	18	,	,	PUNCT
admet-1513	418	19	such	such	ADJ
admet-1513	418	20	as	as	ADP
admet-1513	418	21	primary	primary	ADJ
admet-1513	418	22	human	human	ADJ
admet-1513	418	23	cardiac	cardiac	ADJ
admet-1513	418	24	fibroblasts	fibroblast	NOUN
admet-1513	418	25	,	,	PUNCT
admet-1513	418	26	can	can	AUX
admet-1513	418	27	not	not	PART
admet-1513	418	28	be	be	AUX
admet-1513	418	29	neglected	neglect	VERB
admet-1513	418	30	in	in	ADP
admet-1513	418	31	studying	study	VERB
admet-1513	418	32	the	the	DET
admet-1513	418	33	dict	dict	NOUN
admet-1513	419	1	[	[	X
admet-1513	419	2	170	170	NUM
admet-1513	419	3	]	]	PUNCT
admet-1513	419	4	.	.	PUNCT
admet-1513	420	1	3d	3d	NUM
admet-1513	420	2	human	human	ADJ
admet-1513	420	3	cardiac	cardiac	ADJ
admet-1513	420	4	organoids	organoid	NOUN
admet-1513	420	5	have	have	AUX
admet-1513	420	6	gained	gain	VERB
admet-1513	420	7	importance	importance	NOUN
admet-1513	420	8	as	as	SCONJ
admet-1513	420	9	they	they	PRON
admet-1513	420	10	mimic	mimic	VERB
admet-1513	420	11	human	human	ADJ
admet-1513	420	12	cardiac	cardiac	ADJ
admet-1513	420	13	physiological	physiological	ADJ
admet-1513	420	14	characteristics	characteristic	NOUN
admet-1513	420	15	in	in	ADP
admet-1513	420	16	vitro	vitro	VERB
admet-1513	420	17	.	.	PUNCT
admet-1513	421	1	several	several	ADJ
admet-1513	421	2	researchers	researcher	NOUN
admet-1513	421	3	have	have	AUX
admet-1513	421	4	developed	develop	VERB
admet-1513	421	5	3d	3d	NUM
admet-1513	421	6	cardiac	cardiac	ADJ
admet-1513	421	7	organoids	organoid	NOUN
admet-1513	421	8	by	by	ADP
admet-1513	421	9	assembling	assemble	VERB
admet-1513	421	10	cell	cell	NOUN
admet-1513	421	11	suspensions	suspension	NOUN
admet-1513	421	12	composed	compose	VERB
admet-1513	421	13	of	of	ADP
admet-1513	421	14	psc	psc	NOUN
admet-1513	421	15	-	-	PUNCT
admet-1513	421	16	derived	derive	VERB
admet-1513	421	17	cms	cms	NOUN
admet-1513	421	18	and	and	CCONJ
admet-1513	421	19	various	various	ADJ
admet-1513	421	20	non	non	ADJ
admet-1513	421	21	-	-	ADJ
admet-1513	421	22	cms	cms	NOUN
admet-1513	421	23	are	be	AUX
admet-1513	421	24	seeded	seed	VERB
admet-1513	421	25	in	in	ADP
admet-1513	421	26	hydrogel	hydrogel	NOUN
admet-1513	421	27	molds	mold	NOUN
admet-1513	421	28	with	with	ADP
admet-1513	421	29	ecm	ecm	NOUN
admet-1513	421	30	[	[	X
admet-1513	421	31	178	178	NUM
admet-1513	421	32	-	-	SYM
admet-1513	421	33	181	181	NUM
admet-1513	421	34	]	]	PUNCT
admet-1513	421	35	.	.	PUNCT
admet-1513	422	1	cardiac	cardiac	ADJ
admet-1513	422	2	organoids	organoid	NOUN
admet-1513	422	3	generated	generate	VERB
admet-1513	422	4	through	through	ADP
admet-1513	422	5	this	this	DET
admet-1513	422	6	approach	approach	NOUN
admet-1513	422	7	have	have	AUX
admet-1513	422	8	shown	show	VERB
admet-1513	422	9	better	well	ADJ
admet-1513	422	10	similarity	similarity	NOUN
admet-1513	422	11	admet	admet	PROPN
admet-1513	422	12	&	&	CCONJ
admet-1513	422	13	dmpk	dmpk	PROPN
admet-1513	422	14	11(1	11(1	NUM
admet-1513	422	15	)	)	PUNCT
admet-1513	422	16	(	(	PUNCT
admet-1513	422	17	2023	2023	NUM
admet-1513	422	18	)	)	PUNCT
admet-1513	422	19	1	1	NUM
admet-1513	422	20	-	-	SYM
admet-1513	422	21	32	32	NUM
admet-1513	422	22	2d	2d	NOUN
admet-1513	422	23	and	and	CCONJ
admet-1513	422	24	3d	3d	NOUN
admet-1513	422	25	adme	adme	PROPN
admet-1513	422	26	-	-	PUNCT
admet-1513	422	27	tox	tox	NOUN
admet-1513	422	28	cell	cell	NOUN
admet-1513	422	29	culture	culture	NOUN
admet-1513	422	30	screening	screen	VERB
admet-1513	422	31	:	:	PUNCT
admet-1513	422	32	a	a	DET
admet-1513	422	33	review	review	NOUN
admet-1513	422	34	doi	doi	NOUN
admet-1513	422	35	:	:	PUNCT
admet-1513	422	36	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	422	37	15	15	NUM
admet-1513	422	38	to	to	ADP
admet-1513	422	39	the	the	DET
admet-1513	422	40	human	human	ADJ
admet-1513	422	41	heart	heart	NOUN
admet-1513	422	42	and	and	CCONJ
admet-1513	422	43	can	can	AUX
admet-1513	422	44	be	be	AUX
admet-1513	422	45	useful	useful	ADJ
admet-1513	422	46	for	for	ADP
admet-1513	422	47	disease	disease	NOUN
admet-1513	422	48	modelling	modelling	NOUN
admet-1513	422	49	,	,	PUNCT
admet-1513	422	50	regenerative	regenerative	ADJ
admet-1513	422	51	medicine	medicine	NOUN
admet-1513	422	52	and	and	CCONJ
admet-1513	422	53	drug	drug	NOUN
admet-1513	422	54	development	development	NOUN
admet-1513	422	55	[	[	X
admet-1513	422	56	170	170	NUM
admet-1513	422	57	]	]	PUNCT
admet-1513	422	58	.	.	PUNCT
admet-1513	423	1	in	in	ADP
admet-1513	423	2	another	another	DET
admet-1513	423	3	approach	approach	NOUN
admet-1513	423	4	,	,	PUNCT
admet-1513	423	5	researchers	researcher	NOUN
admet-1513	423	6	implanted	implant	VERB
admet-1513	423	7	suspensions	suspension	NOUN
admet-1513	423	8	of	of	ADP
admet-1513	423	9	both	both	CCONJ
admet-1513	423	10	hipsc	hipsc	ADJ
admet-1513	423	11	-	-	PUNCT
admet-1513	423	12	derived	derive	VERB
admet-1513	423	13	cms	cms	NOUN
admet-1513	423	14	and	and	CCONJ
admet-1513	423	15	cardiac	cardiac	ADJ
admet-1513	423	16	fibroblasts	fibroblast	NOUN
admet-1513	423	17	in	in	ADP
admet-1513	423	18	hydrogels	hydrogel	NOUN
admet-1513	423	19	and	and	CCONJ
admet-1513	423	20	cultivated	cultivate	VERB
admet-1513	423	21	them	they	PRON
admet-1513	423	22	on	on	ADP
admet-1513	423	23	a	a	DET
admet-1513	423	24	biowiretm	biowiretm	NOUN
admet-1513	423	25	ii	ii	NOUN
admet-1513	423	26	platform	platform	NOUN
admet-1513	423	27	for	for	ADP
admet-1513	423	28	the	the	DET
admet-1513	423	29	generation	generation	NOUN
admet-1513	423	30	of	of	ADP
admet-1513	423	31	organoids	organoid	NOUN
admet-1513	423	32	.	.	PUNCT
admet-1513	424	1	this	this	DET
admet-1513	424	2	platform	platform	NOUN
admet-1513	424	3	helps	helps	AUX
admet-1513	424	4	record	record	VERB
admet-1513	424	5	cardiac	cardiac	ADJ
admet-1513	424	6	contractions	contraction	NOUN
admet-1513	424	7	,	,	PUNCT
admet-1513	424	8	action	action	NOUN
admet-1513	424	9	potentials	potential	NOUN
admet-1513	424	10	and	and	CCONJ
admet-1513	424	11	conduct	conduct	VERB
admet-1513	424	12	velocities	velocity	NOUN
admet-1513	424	13	[	[	X
admet-1513	424	14	182	182	NUM
admet-1513	424	15	]	]	PUNCT
admet-1513	424	16	.	.	PUNCT
admet-1513	425	1	a	a	DET
admet-1513	425	2	similar	similar	ADJ
admet-1513	425	3	approach	approach	NOUN
admet-1513	425	4	has	have	AUX
admet-1513	425	5	been	be	AUX
admet-1513	425	6	used	use	VERB
admet-1513	425	7	to	to	PART
admet-1513	425	8	study	study	VERB
admet-1513	425	9	the	the	DET
admet-1513	425	10	effect	effect	NOUN
admet-1513	425	11	of	of	ADP
admet-1513	425	12	various	various	ADJ
admet-1513	425	13	inotropes	inotrope	NOUN
admet-1513	425	14	on	on	ADP
admet-1513	425	15	cardiac	cardiac	ADJ
admet-1513	425	16	contractility	contractility	NOUN
admet-1513	425	17	and	and	CCONJ
admet-1513	425	18	observed	observe	VERB
admet-1513	425	19	good	good	ADJ
admet-1513	425	20	concordance	concordance	NOUN
admet-1513	425	21	,	,	PUNCT
admet-1513	425	22	suggesting	suggest	VERB
admet-1513	425	23	the	the	DET
admet-1513	425	24	broad	broad	ADJ
admet-1513	425	25	application	application	NOUN
admet-1513	425	26	of	of	ADP
admet-1513	425	27	this	this	DET
admet-1513	425	28	assay	assay	NOUN
admet-1513	425	29	platform	platform	NOUN
admet-1513	425	30	in	in	ADP
admet-1513	425	31	the	the	DET
admet-1513	425	32	drug	drug	NOUN
admet-1513	425	33	discovery	discovery	NOUN
admet-1513	425	34	process	process	NOUN
admet-1513	425	35	[	[	X
admet-1513	425	36	183,184	183,184	NUM
admet-1513	425	37	]	]	PUNCT
admet-1513	425	38	.	.	PUNCT
admet-1513	426	1	in	in	ADP
admet-1513	426	2	another	another	DET
admet-1513	426	3	study	study	NOUN
admet-1513	426	4	,	,	PUNCT
admet-1513	426	5	researchers	researcher	NOUN
admet-1513	426	6	developed	develop	VERB
admet-1513	426	7	3d	3d	PROPN
admet-1513	426	8	electromechanically	electromechanically	ADV
admet-1513	426	9	coupled	couple	VERB
admet-1513	426	10	in	in	ADP
admet-1513	426	11	vitro	vitro	X
admet-1513	426	12	fluid	fluid	ADJ
admet-1513	426	13	pumping	pumping	NOUN
admet-1513	426	14	chambers	chamber	NOUN
admet-1513	426	15	that	that	PRON
admet-1513	426	16	mimic	mimic	VERB
admet-1513	426	17	ventricular	ventricular	ADJ
admet-1513	426	18	contractions	contraction	NOUN
admet-1513	426	19	[	[	X
admet-1513	426	20	185,186	185,186	NUM
admet-1513	426	21	]	]	PUNCT
admet-1513	426	22	.	.	PUNCT
admet-1513	427	1	using	use	VERB
admet-1513	427	2	this	this	DET
admet-1513	427	3	engineered	engineer	VERB
admet-1513	427	4	technology	technology	NOUN
admet-1513	427	5	,	,	PUNCT
admet-1513	427	6	they	they	PRON
admet-1513	427	7	were	be	AUX
admet-1513	427	8	able	able	ADJ
admet-1513	427	9	to	to	PART
admet-1513	427	10	measure	measure	VERB
admet-1513	427	11	the	the	DET
admet-1513	427	12	cardiac	cardiac	ADJ
admet-1513	427	13	output	output	NOUN
admet-1513	427	14	and	and	CCONJ
admet-1513	427	15	stroke	stroke	NOUN
admet-1513	427	16	volume	volume	NOUN
admet-1513	427	17	for	for	ADP
admet-1513	427	18	25	25	NUM
admet-1513	427	19	cardioactive	cardioactive	ADJ
admet-1513	427	20	compounds	compound	NOUN
admet-1513	427	21	and	and	CCONJ
admet-1513	427	22	achieved	achieve	VERB
admet-1513	427	23	80	80	NUM
admet-1513	427	24	-	-	SYM
admet-1513	427	25	100	100	NUM
admet-1513	427	26	%	%	NOUN
admet-1513	427	27	accuracy	accuracy	NOUN
admet-1513	427	28	in	in	ADP
admet-1513	427	29	assay	assay	PROPN
admet-1513	427	30	prediction	prediction	NOUN
admet-1513	427	31	.	.	PUNCT
admet-1513	428	1	archer	archer	PROPN
admet-1513	428	2	and	and	CCONJ
admet-1513	428	3	colleagues	colleague	NOUN
admet-1513	429	1	[	[	X
admet-1513	429	2	187	187	NUM
admet-1513	429	3	]	]	PUNCT
admet-1513	429	4	have	have	AUX
admet-1513	429	5	developed	develop	VERB
admet-1513	429	6	organoids	organoid	NOUN
admet-1513	429	7	consisting	consist	VERB
admet-1513	429	8	of	of	ADP
admet-1513	429	9	cms	cms	NOUN
admet-1513	429	10	,	,	PUNCT
admet-1513	429	11	cardiac	cardiac	ADJ
admet-1513	429	12	fibroblasts	fibroblast	NOUN
admet-1513	429	13	and	and	CCONJ
admet-1513	429	14	cardiac	cardiac	ADJ
admet-1513	429	15	microvascular	microvascular	ADJ
admet-1513	429	16	endothelial	endothelial	ADJ
admet-1513	429	17	cells	cell	NOUN
admet-1513	429	18	.	.	PUNCT
admet-1513	430	1	using	use	VERB
admet-1513	430	2	these	these	DET
admet-1513	430	3	organoids	organoid	NOUN
admet-1513	430	4	,	,	PUNCT
admet-1513	430	5	they	they	PRON
admet-1513	430	6	were	be	AUX
admet-1513	430	7	able	able	ADJ
admet-1513	430	8	to	to	PART
admet-1513	430	9	measure	measure	VERB
admet-1513	430	10	different	different	ADJ
admet-1513	430	11	parameters	parameter	NOUN
admet-1513	430	12	like	like	ADP
admet-1513	430	13	atp	atp	PROPN
admet-1513	430	14	depletion	depletion	NOUN
admet-1513	430	15	,	,	PUNCT
admet-1513	430	16	mitochondrial	mitochondrial	ADJ
admet-1513	430	17	membrane	membrane	NOUN
admet-1513	430	18	potential	potential	NOUN
admet-1513	430	19	and	and	CCONJ
admet-1513	430	20	endoplasmic	endoplasmic	ADJ
admet-1513	430	21	reticulum	reticulum	NOUN
admet-1513	430	22	integrity	integrity	NOUN
admet-1513	430	23	for	for	ADP
admet-1513	430	24	29	29	NUM
admet-1513	430	25	fda	fda	PROPN
admet-1513	430	26	-	-	PUNCT
admet-1513	430	27	approved	approve	VERB
admet-1513	430	28	cardiotoxins	cardiotoxin	NOUN
admet-1513	430	29	.	.	PUNCT
admet-1513	431	1	interestingly	interestingly	ADV
admet-1513	431	2	,	,	PUNCT
admet-1513	431	3	using	use	VERB
admet-1513	431	4	cardiac	cardiac	ADJ
admet-1513	431	5	organoids	organoid	NOUN
admet-1513	431	6	post	post	ADJ
admet-1513	431	7	-	-	ADJ
admet-1513	431	8	myocardial	myocardial	ADJ
admet-1513	431	9	infractions	infraction	NOUN
admet-1513	431	10	were	be	AUX
admet-1513	431	11	also	also	ADV
admet-1513	431	12	modelled	model	VERB
admet-1513	431	13	in	in	ADP
admet-1513	431	14	vitro	vitro	NOUN
admet-1513	431	15	and	and	CCONJ
admet-1513	431	16	reported	report	VERB
admet-1513	431	17	doxorubicin	doxorubicin	PROPN
admet-1513	431	18	-	-	PUNCT
admet-1513	431	19	cardiotoxicity	cardiotoxicity	NOUN
admet-1513	431	20	[	[	X
admet-1513	431	21	188	188	NUM
admet-1513	431	22	]	]	PUNCT
admet-1513	431	23	.	.	PUNCT
admet-1513	432	1	however	however	ADV
admet-1513	432	2	,	,	PUNCT
admet-1513	432	3	the	the	DET
admet-1513	432	4	cardiac	cardiac	ADJ
admet-1513	432	5	organoids	organoid	NOUN
admet-1513	432	6	reported	report	VERB
admet-1513	432	7	till	till	SCONJ
admet-1513	432	8	now	now	ADV
admet-1513	432	9	do	do	AUX
admet-1513	432	10	n’t	not	PART
admet-1513	432	11	contain	contain	VERB
admet-1513	432	12	all	all	DET
admet-1513	432	13	the	the	DET
admet-1513	432	14	cell	cell	NOUN
admet-1513	432	15	types	type	NOUN
admet-1513	432	16	present	present	ADJ
admet-1513	432	17	in	in	ADP
admet-1513	432	18	the	the	DET
admet-1513	432	19	adult	adult	NOUN
admet-1513	432	20	human	human	ADJ
admet-1513	432	21	heart	heart	NOUN
admet-1513	432	22	,	,	PUNCT
admet-1513	432	23	such	such	ADJ
admet-1513	432	24	as	as	ADP
admet-1513	432	25	immune	immune	ADJ
admet-1513	432	26	cells	cell	NOUN
admet-1513	432	27	,	,	PUNCT
admet-1513	432	28	which	which	PRON
admet-1513	432	29	protect	protect	VERB
admet-1513	432	30	against	against	ADP
admet-1513	432	31	inflammation	inflammation	NOUN
admet-1513	432	32	.	.	PUNCT
admet-1513	433	1	thus	thus	ADV
admet-1513	433	2	,	,	PUNCT
admet-1513	433	3	novel	novel	ADJ
admet-1513	433	4	technologies	technology	NOUN
admet-1513	433	5	have	have	VERB
admet-1513	433	6	to	to	PART
admet-1513	433	7	be	be	AUX
admet-1513	433	8	implemented	implement	VERB
admet-1513	433	9	,	,	PUNCT
admet-1513	433	10	such	such	ADJ
admet-1513	433	11	as	as	ADP
admet-1513	433	12	co	co	VERB
admet-1513	433	13	-	-	VERB
admet-1513	433	14	culturing	culture	VERB
admet-1513	433	15	with	with	ADP
admet-1513	433	16	immune	immune	ADJ
admet-1513	433	17	cells	cell	NOUN
admet-1513	433	18	may	may	AUX
admet-1513	433	19	help	help	VERB
admet-1513	433	20	gain	gain	VERB
admet-1513	433	21	knowledge	knowledge	NOUN
admet-1513	433	22	on	on	ADP
admet-1513	433	23	interactions	interaction	NOUN
admet-1513	433	24	between	between	ADP
admet-1513	433	25	cms	cms	NOUN
admet-1513	433	26	and	and	CCONJ
admet-1513	433	27	immune	immune	ADJ
admet-1513	433	28	cells	cell	NOUN
admet-1513	433	29	.	.	PUNCT
admet-1513	434	1	another	another	DET
admet-1513	434	2	drawback	drawback	NOUN
admet-1513	434	3	with	with	ADP
admet-1513	434	4	cardiac	cardiac	ADJ
admet-1513	434	5	organoids	organoid	NOUN
admet-1513	434	6	is	be	AUX
admet-1513	434	7	the	the	DET
admet-1513	434	8	degree	degree	NOUN
admet-1513	434	9	of	of	ADP
admet-1513	434	10	maturation	maturation	NOUN
admet-1513	434	11	of	of	ADP
admet-1513	434	12	different	different	ADJ
admet-1513	434	13	cell	cell	NOUN
admet-1513	434	14	types	type	NOUN
admet-1513	434	15	is	be	AUX
admet-1513	434	16	not	not	PART
admet-1513	434	17	similar	similar	ADJ
admet-1513	434	18	to	to	ADP
admet-1513	434	19	that	that	PRON
admet-1513	434	20	of	of	ADP
admet-1513	434	21	adult	adult	NOUN
admet-1513	434	22	human	human	ADJ
admet-1513	434	23	tissue	tissue	NOUN
admet-1513	434	24	.	.	PUNCT
admet-1513	435	1	efforts	effort	NOUN
admet-1513	435	2	toward	toward	ADP
admet-1513	435	3	maturation	maturation	NOUN
admet-1513	435	4	will	will	AUX
admet-1513	435	5	help	help	VERB
admet-1513	435	6	in	in	ADP
admet-1513	435	7	toxicity	toxicity	NOUN
admet-1513	435	8	prediction	prediction	NOUN
admet-1513	435	9	more	more	ADV
admet-1513	435	10	accurately	accurately	ADV
admet-1513	435	11	[	[	X
admet-1513	435	12	189	189	NUM
admet-1513	435	13	]	]	PUNCT
admet-1513	435	14	.	.	PUNCT
admet-1513	436	1	drug	drug	NOUN
admet-1513	436	2	-	-	PUNCT
admet-1513	436	3	induced	induce	VERB
admet-1513	436	4	kidney	kidney	NOUN
admet-1513	436	5	injury	injury	NOUN
admet-1513	436	6	(	(	PUNCT
admet-1513	436	7	diki	diki	PROPN
admet-1513	436	8	)	)	PUNCT
admet-1513	436	9	is	be	AUX
admet-1513	436	10	also	also	ADV
admet-1513	436	11	another	another	DET
admet-1513	436	12	problem	problem	NOUN
admet-1513	436	13	causing	cause	VERB
admet-1513	436	14	almost	almost	ADV
admet-1513	436	15	19	19	NUM
admet-1513	436	16	%	%	NOUN
admet-1513	436	17	of	of	ADP
admet-1513	436	18	acute	acute	ADJ
admet-1513	436	19	renal	renal	ADJ
admet-1513	436	20	failures	failure	NOUN
admet-1513	436	21	worldwide	worldwide	ADV
admet-1513	436	22	[	[	X
admet-1513	436	23	190	190	NUM
admet-1513	436	24	]	]	PUNCT
admet-1513	436	25	.	.	PUNCT
admet-1513	437	1	drugs	drug	NOUN
admet-1513	437	2	like	like	ADP
admet-1513	437	3	cisplatin	cisplatin	NOUN
admet-1513	437	4	,	,	PUNCT
admet-1513	437	5	nsaids	nsaid	NOUN
admet-1513	437	6	,	,	PUNCT
admet-1513	437	7	and	and	CCONJ
admet-1513	437	8	antibiotics	antibiotic	NOUN
admet-1513	437	9	cause	cause	VERB
admet-1513	437	10	diki	diki	NOUN
admet-1513	438	1	[	[	X
admet-1513	438	2	191	191	NUM
admet-1513	438	3	]	]	PUNCT
admet-1513	438	4	.	.	PUNCT
admet-1513	439	1	there	there	PRON
admet-1513	439	2	is	be	VERB
admet-1513	439	3	no	no	DET
admet-1513	439	4	ideal	ideal	ADJ
admet-1513	439	5	2d	2d	NOUN
admet-1513	439	6	in	in	ADP
admet-1513	439	7	vitro	vitro	X
admet-1513	439	8	assays	assay	NOUN
admet-1513	439	9	available	available	ADJ
admet-1513	439	10	for	for	ADP
admet-1513	439	11	studying	study	VERB
admet-1513	439	12	the	the	DET
admet-1513	439	13	diki	diki	NOUN
admet-1513	439	14	.	.	PUNCT
admet-1513	440	1	to	to	ADP
admet-1513	440	2	date	date	NOUN
admet-1513	440	3	,	,	PUNCT
admet-1513	440	4	diki	diki	PROPN
admet-1513	440	5	is	be	AUX
admet-1513	440	6	predicted	predict	VERB
admet-1513	440	7	by	by	ADP
admet-1513	440	8	using	use	VERB
admet-1513	440	9	only	only	ADV
admet-1513	440	10	human	human	ADJ
admet-1513	440	11	renal	renal	ADJ
admet-1513	440	12	proximal	proximal	ADJ
admet-1513	440	13	tubule	tubule	NOUN
admet-1513	440	14	epithelial	epithelial	ADJ
admet-1513	440	15	cells	cell	NOUN
admet-1513	440	16	(	(	PUNCT
admet-1513	440	17	rpte	rpte	NOUN
admet-1513	440	18	)	)	PUNCT
admet-1513	440	19	in	in	ADP
admet-1513	440	20	vitro	vitro	X
admet-1513	441	1	[	[	X
admet-1513	441	2	192	192	NUM
admet-1513	441	3	]	]	PUNCT
admet-1513	441	4	.	.	PUNCT
admet-1513	442	1	however	however	ADV
admet-1513	442	2	,	,	PUNCT
admet-1513	442	3	this	this	DET
admet-1513	442	4	model	model	NOUN
admet-1513	442	5	predicts	predict	VERB
admet-1513	442	6	almost	almost	ADV
admet-1513	442	7	80	80	NUM
admet-1513	442	8	%	%	NOUN
admet-1513	442	9	of	of	ADP
admet-1513	442	10	diki	diki	PROPN
admet-1513	442	11	.	.	PUNCT
admet-1513	443	1	but	but	CCONJ
admet-1513	443	2	the	the	DET
admet-1513	443	3	kidney	kidney	NOUN
admet-1513	443	4	is	be	AUX
admet-1513	443	5	a	a	DET
admet-1513	443	6	complex	complex	ADJ
admet-1513	443	7	organ	organ	NOUN
admet-1513	443	8	consisting	consisting	NOUN
admet-1513	443	9	of	of	ADP
admet-1513	443	10	more	more	ADJ
admet-1513	443	11	than	than	ADP
admet-1513	443	12	20	20	NUM
admet-1513	443	13	different	different	ADJ
admet-1513	443	14	cell	cell	NOUN
admet-1513	443	15	types	type	NOUN
admet-1513	443	16	having	have	VERB
admet-1513	443	17	variable	variable	ADJ
admet-1513	443	18	toxicity	toxicity	NOUN
admet-1513	443	19	with	with	ADP
admet-1513	443	20	different	different	ADJ
admet-1513	443	21	nephrotoxic	nephrotoxic	ADJ
admet-1513	443	22	compounds	compound	NOUN
admet-1513	443	23	.	.	PUNCT
admet-1513	444	1	to	to	PART
admet-1513	444	2	address	address	VERB
admet-1513	444	3	these	these	DET
admet-1513	444	4	issues	issue	NOUN
admet-1513	444	5	,	,	PUNCT
admet-1513	444	6	researchers	researcher	NOUN
admet-1513	444	7	started	start	VERB
admet-1513	444	8	developing	develop	VERB
admet-1513	444	9	3d	3d	NOUN
admet-1513	444	10	-	-	PUNCT
admet-1513	444	11	based	base	VERB
admet-1513	444	12	human	human	ADJ
admet-1513	444	13	renal	renal	ADJ
admet-1513	444	14	tissue	tissue	NOUN
admet-1513	444	15	systems	system	NOUN
admet-1513	444	16	.	.	PUNCT
admet-1513	445	1	the	the	DET
admet-1513	445	2	3d	3d	PROPN
admet-1513	445	3	systems	system	NOUN
admet-1513	445	4	developed	develop	VERB
admet-1513	445	5	using	use	VERB
admet-1513	445	6	human	human	ADJ
admet-1513	445	7	renal	renal	ADJ
admet-1513	445	8	cortical	cortical	ADJ
admet-1513	445	9	nki-2	nki-2	PUNCT
admet-1513	445	10	cells	cell	NOUN
admet-1513	445	11	showed	show	VERB
admet-1513	445	12	more	more	ADJ
admet-1513	445	13	sensitivity	sensitivity	NOUN
admet-1513	445	14	to	to	ADP
admet-1513	445	15	cisplatin	cisplatin	NOUN
admet-1513	445	16	,	,	PUNCT
admet-1513	445	17	doxorubicin	doxorubicin	PROPN
admet-1513	445	18	and	and	CCONJ
admet-1513	445	19	gentamicin	gentamicin	NOUN
admet-1513	445	20	than	than	ADP
admet-1513	445	21	2d	2d	NUM
admet-1513	445	22	adherent	adherent	NOUN
admet-1513	445	23	nki-2	nki-2	PUNCT
admet-1513	445	24	cells	cell	NOUN
admet-1513	445	25	[	[	X
admet-1513	445	26	193	193	NUM
admet-1513	445	27	]	]	PUNCT
admet-1513	445	28	.	.	PUNCT
admet-1513	446	1	3d	3d	NUM
admet-1513	446	2	kidney	kidney	NOUN
admet-1513	446	3	organoids	organoid	NOUN
admet-1513	446	4	developed	develop	VERB
admet-1513	446	5	from	from	ADP
admet-1513	446	6	hipsc	hipsc	ADJ
admet-1513	446	7	contain	contain	NOUN
admet-1513	446	8	proximal	proximal	ADJ
admet-1513	446	9	tubules	tubule	NOUN
admet-1513	446	10	,	,	PUNCT
admet-1513	446	11	podocytes	podocyte	NOUN
admet-1513	446	12	and	and	CCONJ
admet-1513	446	13	endothelial	endothelial	NOUN
admet-1513	446	14	cells	cell	NOUN
admet-1513	446	15	[	[	X
admet-1513	446	16	194	194	NUM
admet-1513	446	17	]	]	PUNCT
admet-1513	446	18	.	.	PUNCT
admet-1513	447	1	these	these	DET
admet-1513	447	2	organoids	organoid	NOUN
admet-1513	447	3	showed	show	VERB
admet-1513	447	4	overexpression	overexpression	NOUN
admet-1513	447	5	of	of	ADP
admet-1513	447	6	kim-1	kim-1	NUM
admet-1513	447	7	upon	upon	SCONJ
admet-1513	447	8	treatment	treatment	NOUN
admet-1513	447	9	with	with	ADP
admet-1513	447	10	cisplatin	cisplatin	NOUN
admet-1513	447	11	and	and	CCONJ
admet-1513	447	12	gentamycin	gentamycin	PROPN
admet-1513	447	13	.	.	PUNCT
admet-1513	448	1	czerniecki	czerniecki	NOUN
admet-1513	448	2	and	and	CCONJ
admet-1513	448	3	colleagues	colleague	NOUN
admet-1513	449	1	[	[	X
admet-1513	449	2	195	195	NUM
admet-1513	449	3	]	]	PUNCT
admet-1513	449	4	developed	develop	VERB
admet-1513	449	5	a	a	DET
admet-1513	449	6	high	high	ADJ
admet-1513	449	7	throughput	throughput	NOUN
admet-1513	449	8	screening	screen	VERB
admet-1513	449	9	platform	platform	NOUN
admet-1513	449	10	for	for	ADP
admet-1513	449	11	the	the	DET
admet-1513	449	12	generation	generation	NOUN
admet-1513	449	13	of	of	ADP
admet-1513	449	14	kidney	kidney	NOUN
admet-1513	449	15	organoids	organoid	NOUN
admet-1513	449	16	from	from	ADP
admet-1513	449	17	hipsc	hipsc	ADJ
admet-1513	449	18	and	and	CCONJ
admet-1513	449	19	performed	perform	VERB
admet-1513	449	20	toxicity	toxicity	NOUN
admet-1513	449	21	analysis	analysis	NOUN
admet-1513	449	22	for	for	ADP
admet-1513	449	23	polycystic	polycystic	ADJ
admet-1513	449	24	kidney	kidney	NOUN
admet-1513	449	25	disease	disease	NOUN
admet-1513	449	26	.	.	PUNCT
admet-1513	450	1	king	king	NOUN
admet-1513	450	2	and	and	CCONJ
admet-1513	450	3	colleagues	colleague	NOUN
admet-1513	451	1	[	[	X
admet-1513	451	2	196	196	NUM
admet-1513	451	3	]	]	PUNCT
admet-1513	451	4	developed	develop	VERB
admet-1513	451	5	3d	3d	NUM
admet-1513	451	6	proximal	proximal	ADJ
admet-1513	451	7	tubule	tubule	ADJ
admet-1513	451	8	tissue	tissue	NOUN
admet-1513	451	9	consisting	consist	VERB
admet-1513	451	10	of	of	ADP
admet-1513	451	11	rpte	rpte	NOUN
admet-1513	451	12	,	,	PUNCT
admet-1513	451	13	renal	renal	ADJ
admet-1513	451	14	fibroblasts	fibroblast	NOUN
admet-1513	451	15	and	and	CCONJ
admet-1513	451	16	endothelial	endothelial	NOUN
admet-1513	451	17	cells	cell	NOUN
admet-1513	451	18	using	use	VERB
admet-1513	451	19	a	a	DET
admet-1513	451	20	3d	3d	NUM
admet-1513	451	21	bioprinting	bioprinting	NOUN
admet-1513	451	22	platform	platform	NOUN
admet-1513	451	23	and	and	CCONJ
admet-1513	451	24	observed	observe	VERB
admet-1513	451	25	the	the	DET
admet-1513	451	26	formation	formation	NOUN
admet-1513	451	27	of	of	ADP
admet-1513	451	28	tight	tight	ADJ
admet-1513	451	29	junctions	junction	NOUN
admet-1513	451	30	,	,	PUNCT
admet-1513	451	31	elevated	elevated	ADJ
admet-1513	451	32	renal	renal	ADJ
admet-1513	451	33	uptake	uptake	NOUN
admet-1513	451	34	and	and	CCONJ
admet-1513	451	35	efflux	efflux	VERB
admet-1513	451	36	transporter	transporter	NOUN
admet-1513	451	37	levels	level	NOUN
admet-1513	451	38	and	and	CCONJ
admet-1513	451	39	polarized	polarize	VERB
admet-1513	451	40	localization	localization	NOUN
admet-1513	451	41	and	and	CCONJ
admet-1513	451	42	function	function	NOUN
admet-1513	451	43	of	of	ADP
admet-1513	451	44	p	p	NOUN
admet-1513	451	45	-	-	PUNCT
admet-1513	451	46	gp	gp	NOUN
admet-1513	451	47	and	and	CCONJ
admet-1513	451	48	sglt2	sglt2	PROPN
admet-1513	451	49	.	.	PUNCT
admet-1513	452	1	these	these	DET
admet-1513	452	2	organoids	organoid	NOUN
admet-1513	452	3	showed	show	VERB
admet-1513	452	4	dose	dose	NOUN
admet-1513	452	5	-	-	PUNCT
admet-1513	452	6	dependent	dependent	ADJ
admet-1513	452	7	cisplatin	cisplatin	NOUN
admet-1513	452	8	toxicity	toxicity	NOUN
admet-1513	452	9	and	and	CCONJ
admet-1513	452	10	rescuing	rescue	VERB
admet-1513	452	11	effects	effect	NOUN
admet-1513	452	12	of	of	ADP
admet-1513	452	13	cimetidine	cimetidine	NOUN
admet-1513	452	14	,	,	PUNCT
admet-1513	452	15	thus	thus	ADV
admet-1513	452	16	confirming	confirm	VERB
admet-1513	452	17	the	the	DET
admet-1513	452	18	role	role	NOUN
admet-1513	452	19	of	of	ADP
admet-1513	452	20	oct2	oct2	NOUN
admet-1513	452	21	transporter	transporter	NOUN
admet-1513	452	22	in	in	ADP
admet-1513	452	23	cisplatin	cisplatin	NOUN
admet-1513	452	24	-	-	PUNCT
admet-1513	452	25	mediated	mediate	VERB
admet-1513	452	26	toxicity	toxicity	NOUN
admet-1513	452	27	.	.	PUNCT
admet-1513	453	1	to	to	ADP
admet-1513	453	2	date	date	NOUN
admet-1513	453	3	,	,	PUNCT
admet-1513	453	4	all	all	DET
admet-1513	453	5	the	the	DET
admet-1513	453	6	studies	study	NOUN
admet-1513	453	7	on	on	ADP
admet-1513	453	8	kidney	kidney	NOUN
admet-1513	453	9	organoids	organoid	NOUN
admet-1513	453	10	have	have	AUX
admet-1513	453	11	targeted	target	VERB
admet-1513	453	12	rpte	rpte	NOUN
admet-1513	453	13	.	.	PUNCT
admet-1513	454	1	however	however	ADV
admet-1513	454	2	,	,	PUNCT
admet-1513	454	3	because	because	SCONJ
admet-1513	454	4	of	of	ADP
admet-1513	454	5	the	the	DET
admet-1513	454	6	complex	complex	ADJ
admet-1513	454	7	nature	nature	NOUN
admet-1513	454	8	of	of	ADP
admet-1513	454	9	the	the	DET
admet-1513	454	10	kidney	kidney	NOUN
admet-1513	454	11	,	,	PUNCT
admet-1513	454	12	it	it	PRON
admet-1513	454	13	is	be	AUX
admet-1513	454	14	also	also	ADV
admet-1513	454	15	important	important	ADJ
admet-1513	454	16	to	to	PART
admet-1513	454	17	develop	develop	VERB
admet-1513	454	18	organoids	organoid	NOUN
admet-1513	454	19	consisting	consist	VERB
admet-1513	454	20	of	of	ADP
admet-1513	454	21	glomerulus	glomerulus	NOUN
admet-1513	454	22	cells	cell	NOUN
admet-1513	454	23	and	and	CCONJ
admet-1513	454	24	prediction	prediction	NOUN
admet-1513	454	25	of	of	ADP
admet-1513	454	26	glomerular	glomerular	ADJ
admet-1513	454	27	toxicity	toxicity	NOUN
admet-1513	454	28	.	.	PUNCT
admet-1513	455	1	further	far	ADV
admet-1513	455	2	,	,	PUNCT
admet-1513	455	3	more	more	ADJ
admet-1513	455	4	efforts	effort	NOUN
admet-1513	455	5	are	be	AUX
admet-1513	455	6	required	require	VERB
admet-1513	455	7	to	to	PART
admet-1513	455	8	create	create	VERB
admet-1513	455	9	innovative	innovative	ADJ
admet-1513	455	10	in	in	ADP
admet-1513	455	11	vitro	vitro	X
admet-1513	455	12	assay	assay	NOUN
admet-1513	455	13	techniques	technique	NOUN
admet-1513	455	14	that	that	PRON
admet-1513	455	15	more	more	ADV
admet-1513	455	16	accurately	accurately	ADV
admet-1513	455	17	depict	depict	VERB
admet-1513	455	18	the	the	DET
admet-1513	455	19	physiological	physiological	ADJ
admet-1513	455	20	processes	process	NOUN
admet-1513	455	21	of	of	ADP
admet-1513	455	22	the	the	DET
admet-1513	455	23	human	human	ADJ
admet-1513	455	24	kidney	kidney	PROPN
admet-1513	455	25	.	.	PUNCT
admet-1513	456	1	drug	drug	NOUN
admet-1513	456	2	-	-	PUNCT
admet-1513	456	3	induced	induce	VERB
admet-1513	456	4	neurotoxicity	neurotoxicity	NOUN
admet-1513	456	5	is	be	AUX
admet-1513	456	6	a	a	DET
admet-1513	456	7	serious	serious	ADJ
admet-1513	456	8	problem	problem	NOUN
admet-1513	456	9	causing	cause	VERB
admet-1513	456	10	both	both	DET
admet-1513	456	11	tissue	tissue	NOUN
admet-1513	456	12	damage	damage	NOUN
admet-1513	456	13	and	and	CCONJ
admet-1513	456	14	functional	functional	ADJ
admet-1513	456	15	impairment	impairment	NOUN
admet-1513	456	16	,	,	PUNCT
admet-1513	456	17	such	such	ADJ
admet-1513	456	18	as	as	ADP
admet-1513	456	19	seizures	seizure	NOUN
admet-1513	456	20	,	,	PUNCT
admet-1513	456	21	leading	lead	VERB
admet-1513	456	22	to	to	ADP
admet-1513	456	23	drug	drug	NOUN
admet-1513	456	24	attrition	attrition	NOUN
admet-1513	456	25	[	[	X
admet-1513	456	26	197	197	NUM
admet-1513	456	27	]	]	PUNCT
admet-1513	456	28	.	.	PUNCT
admet-1513	457	1	previously	previously	ADV
admet-1513	457	2	,	,	PUNCT
admet-1513	457	3	preclinical	preclinical	ADJ
admet-1513	457	4	neurotoxicity	neurotoxicity	NOUN
admet-1513	457	5	assays	assay	NOUN
admet-1513	457	6	were	be	AUX
admet-1513	457	7	predicted	predict	VERB
admet-1513	457	8	only	only	ADV
admet-1513	457	9	by	by	ADP
admet-1513	457	10	using	use	VERB
admet-1513	457	11	in	in	ADP
admet-1513	457	12	vivo	vivo	NOUN
admet-1513	457	13	models	model	NOUN
admet-1513	457	14	.	.	PUNCT
admet-1513	458	1	after	after	ADP
admet-1513	458	2	the	the	DET
admet-1513	458	3	discovery	discovery	NOUN
admet-1513	458	4	of	of	ADP
admet-1513	458	5	hipsc	hipsc	PROPN
admet-1513	458	6	and	and	CCONJ
admet-1513	458	7	the	the	DET
admet-1513	458	8	development	development	NOUN
admet-1513	458	9	of	of	ADP
admet-1513	458	10	methods	method	NOUN
admet-1513	458	11	for	for	ADP
admet-1513	458	12	neuronal	neuronal	ADJ
admet-1513	458	13	cell	cell	NOUN
admet-1513	458	14	differentiation	differentiation	NOUN
admet-1513	458	15	,	,	PUNCT
admet-1513	458	16	in	in	ADP
admet-1513	458	17	vitro	vitro	X
admet-1513	458	18	toxicity	toxicity	NOUN
admet-1513	458	19	assays	assay	NOUN
admet-1513	458	20	were	be	AUX
admet-1513	458	21	developed	develop	VERB
admet-1513	458	22	to	to	PART
admet-1513	458	23	study	study	VERB
admet-1513	458	24	neuronal	neuronal	ADJ
admet-1513	458	25	toxicity	toxicity	NOUN
admet-1513	458	26	using	use	VERB
admet-1513	458	27	hipsc	hipsc	ADJ
admet-1513	458	28	-	-	PUNCT
admet-1513	458	29	derived	derive	VERB
admet-1513	458	30	neurons	neuron	NOUN
admet-1513	458	31	.	.	PUNCT
admet-1513	459	1	the	the	DET
admet-1513	459	2	commonly	commonly	ADV
admet-1513	459	3	used	use	VERB
admet-1513	459	4	2d	2d	NUM
admet-1513	459	5	hipsc	hipsc	ADJ
admet-1513	459	6	-	-	PUNCT
admet-1513	459	7	derived	derive	VERB
admet-1513	459	8	neurons	neuron	NOUN
admet-1513	459	9	in	in	ADP
admet-1513	459	10	vitro	vitro	X
admet-1513	459	11	assays	assay	NOUN
admet-1513	459	12	include	include	VERB
admet-1513	459	13	the	the	DET
admet-1513	459	14	determination	determination	NOUN
admet-1513	459	15	of	of	ADP
admet-1513	459	16	neuronal	neuronal	ADJ
admet-1513	459	17	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	459	18	venkatesh	venkatesh	PROPN
admet-1513	459	19	chunduri	chunduri	PROPN
admet-1513	459	20	and	and	CCONJ
admet-1513	459	21	srinivas	srinivas	PROPN
admet-1513	459	22	maddi	maddi	PROPN
admet-1513	459	23	admet	admet	PROPN
admet-1513	459	24	&	&	CCONJ
admet-1513	459	25	dmpk	dmpk	PROPN
admet-1513	459	26	11(1	11(1	NUM
admet-1513	459	27	)	)	PUNCT
admet-1513	459	28	(	(	PUNCT
admet-1513	459	29	2023	2023	NUM
admet-1513	459	30	)	)	PUNCT
admet-1513	459	31	1	1	NUM
admet-1513	459	32	-	-	SYM
admet-1513	459	33	32	32	NUM
admet-1513	459	34	16	16	NUM
admet-1513	459	35	death	death	NOUN
admet-1513	459	36	neurite	neurite	NOUN
admet-1513	459	37	outgrowth	outgrowth	NOUN
admet-1513	459	38	,	,	PUNCT
admet-1513	459	39	calcium	calcium	NOUN
admet-1513	459	40	oscillation	oscillation	NOUN
admet-1513	459	41	,	,	PUNCT
admet-1513	459	42	and	and	CCONJ
admet-1513	459	43	extracellular	extracellular	ADJ
admet-1513	459	44	field	field	NOUN
admet-1513	459	45	potentials	potential	VERB
admet-1513	459	46	[	[	X
admet-1513	459	47	198	198	NUM
admet-1513	459	48	-	-	SYM
admet-1513	459	49	201	201	NUM
admet-1513	459	50	]	]	PUNCT
admet-1513	459	51	.	.	PUNCT
admet-1513	460	1	however	however	ADV
admet-1513	460	2	,	,	PUNCT
admet-1513	460	3	the	the	DET
admet-1513	460	4	brain	brain	NOUN
admet-1513	460	5	is	be	AUX
admet-1513	460	6	the	the	DET
admet-1513	460	7	most	most	ADV
admet-1513	460	8	complex	complex	ADJ
admet-1513	460	9	organ	organ	NOUN
admet-1513	460	10	there	there	PRON
admet-1513	460	11	is	be	VERB
admet-1513	460	12	a	a	DET
admet-1513	460	13	requirement	requirement	NOUN
admet-1513	460	14	for	for	ADP
admet-1513	460	15	understanding	understand	VERB
admet-1513	460	16	the	the	DET
admet-1513	460	17	structural	structural	ADJ
admet-1513	460	18	and	and	CCONJ
admet-1513	460	19	functional	functional	ADJ
admet-1513	460	20	neurotoxicity	neurotoxicity	NOUN
admet-1513	460	21	.	.	PUNCT
admet-1513	461	1	the	the	DET
admet-1513	461	2	creation	creation	NOUN
admet-1513	461	3	of	of	ADP
admet-1513	461	4	organoids	organoid	NOUN
admet-1513	461	5	has	have	AUX
admet-1513	461	6	opened	open	VERB
admet-1513	461	7	up	up	ADP
admet-1513	461	8	the	the	DET
admet-1513	461	9	scope	scope	NOUN
admet-1513	461	10	of	of	ADP
admet-1513	461	11	understanding	understand	VERB
admet-1513	461	12	the	the	DET
admet-1513	461	13	drug	drug	NOUN
admet-1513	461	14	effects	effect	NOUN
admet-1513	461	15	on	on	ADP
admet-1513	461	16	different	different	ADJ
admet-1513	461	17	parts	part	NOUN
admet-1513	461	18	of	of	ADP
admet-1513	461	19	brain	brain	NOUN
admet-1513	461	20	tissues	tissue	NOUN
admet-1513	461	21	.	.	PUNCT
admet-1513	462	1	moreover	moreover	ADV
admet-1513	462	2	,	,	PUNCT
admet-1513	462	3	brain	brain	NOUN
admet-1513	462	4	organoids	organoid	NOUN
admet-1513	462	5	are	be	AUX
admet-1513	462	6	predicted	predict	VERB
admet-1513	462	7	to	to	PART
admet-1513	462	8	provide	provide	VERB
admet-1513	462	9	vital	vital	ADJ
admet-1513	462	10	information	information	NOUN
admet-1513	462	11	to	to	PART
admet-1513	462	12	increase	increase	VERB
admet-1513	462	13	our	our	PRON
admet-1513	462	14	understanding	understanding	NOUN
admet-1513	462	15	of	of	ADP
admet-1513	462	16	the	the	DET
admet-1513	462	17	mechanisms	mechanism	NOUN
admet-1513	462	18	of	of	ADP
admet-1513	462	19	neurodevelopmental	neurodevelopmental	ADJ
admet-1513	462	20	or	or	CCONJ
admet-1513	462	21	neurodegenerative	neurodegenerative	ADJ
admet-1513	462	22	disorders	disorder	NOUN
admet-1513	462	23	,	,	PUNCT
admet-1513	462	24	as	as	ADV
admet-1513	462	25	well	well	ADV
admet-1513	462	26	as	as	ADP
admet-1513	462	27	useful	useful	ADJ
admet-1513	462	28	tools	tool	NOUN
admet-1513	462	29	for	for	ADP
admet-1513	462	30	disease	disease	NOUN
admet-1513	462	31	modelling	modelling	NOUN
admet-1513	462	32	and	and	CCONJ
admet-1513	462	33	drug	drug	NOUN
admet-1513	462	34	screening	screening	NOUN
admet-1513	463	1	[	[	X
admet-1513	463	2	202	202	NUM
admet-1513	463	3	]	]	PUNCT
admet-1513	463	4	.	.	PUNCT
admet-1513	464	1	the	the	DET
admet-1513	464	2	first	first	ADJ
admet-1513	464	3	report	report	NOUN
admet-1513	464	4	of	of	ADP
admet-1513	464	5	3d	3d	NUM
admet-1513	464	6	self	self	NOUN
admet-1513	464	7	-	-	PUNCT
admet-1513	464	8	organizing	organize	VERB
admet-1513	464	9	cerebral	cerebral	ADJ
admet-1513	464	10	organoids	organoid	NOUN
admet-1513	464	11	was	be	AUX
admet-1513	464	12	reported	report	VERB
admet-1513	464	13	by	by	ADP
admet-1513	464	14	embedding	embed	VERB
admet-1513	464	15	the	the	DET
admet-1513	464	16	neuroectoderm	neuroectoderm	NOUN
admet-1513	464	17	derived	derive	VERB
admet-1513	464	18	from	from	ADP
admet-1513	464	19	human	human	ADJ
admet-1513	464	20	stem	stem	NOUN
admet-1513	464	21	cell	cell	NOUN
admet-1513	464	22	-	-	PUNCT
admet-1513	464	23	induced	induce	VERB
admet-1513	464	24	embryoid	embryoid	NUM
admet-1513	464	25	bodies	body	NOUN
admet-1513	464	26	onto	onto	ADP
admet-1513	464	27	matrix	matrix	NOUN
admet-1513	464	28	gel	gel	NOUN
admet-1513	464	29	[	[	X
admet-1513	464	30	203	203	NUM
admet-1513	464	31	]	]	PUNCT
admet-1513	464	32	.	.	PUNCT
admet-1513	465	1	when	when	SCONJ
admet-1513	465	2	these	these	DET
admet-1513	465	3	embryoid	embryoid	PROPN
admet-1513	465	4	bodies	body	NOUN
admet-1513	465	5	were	be	AUX
admet-1513	465	6	transferred	transfer	VERB
admet-1513	465	7	to	to	ADP
admet-1513	465	8	a	a	DET
admet-1513	465	9	spinning	spinning	NOUN
admet-1513	465	10	bioreactor	bioreactor	NOUN
admet-1513	465	11	,	,	PUNCT
admet-1513	465	12	they	they	PRON
admet-1513	465	13	formed	form	VERB
admet-1513	465	14	self	self	NOUN
admet-1513	465	15	-	-	PUNCT
admet-1513	465	16	organizing	organize	VERB
admet-1513	465	17	cerebral	cerebral	ADJ
admet-1513	465	18	organoids	organoid	NOUN
admet-1513	465	19	.	.	PUNCT
admet-1513	466	1	further	far	ADV
admet-1513	466	2	,	,	PUNCT
admet-1513	466	3	changing	change	VERB
admet-1513	466	4	the	the	DET
admet-1513	466	5	composition	composition	NOUN
admet-1513	466	6	of	of	ADP
admet-1513	466	7	morphogen	morphogen	NOUN
admet-1513	466	8	during	during	ADP
admet-1513	466	9	the	the	DET
admet-1513	466	10	culture	culture	NOUN
admet-1513	466	11	,	,	PUNCT
admet-1513	466	12	these	these	DET
admet-1513	466	13	organoids	organoid	NOUN
admet-1513	466	14	were	be	AUX
admet-1513	466	15	differentiated	differentiate	VERB
admet-1513	466	16	into	into	ADP
admet-1513	466	17	different	different	ADJ
admet-1513	466	18	brain	brain	NOUN
admet-1513	466	19	tissues	tissue	NOUN
admet-1513	466	20	such	such	ADJ
admet-1513	466	21	as	as	ADP
admet-1513	466	22	the	the	DET
admet-1513	466	23	cerebral	cerebral	ADJ
admet-1513	466	24	cortex	cortex	NOUN
admet-1513	466	25	[	[	X
admet-1513	466	26	204	204	NUM
admet-1513	466	27	]	]	PUNCT
admet-1513	466	28	,	,	PUNCT
admet-1513	466	29	hippocampus	hippocampus	NOUN
admet-1513	466	30	[	[	X
admet-1513	466	31	205	205	NUM
admet-1513	466	32	]	]	PUNCT
admet-1513	466	33	,	,	PUNCT
admet-1513	466	34	cerebellum	cerebellum	PROPN
admet-1513	466	35	[	[	X
admet-1513	466	36	206	206	NUM
admet-1513	466	37	]	]	PUNCT
admet-1513	466	38	and	and	CCONJ
admet-1513	466	39	midbrain	midbrain	NOUN
admet-1513	466	40	[	[	X
admet-1513	466	41	207	207	NUM
admet-1513	466	42	]	]	PUNCT
admet-1513	466	43	.	.	PUNCT
admet-1513	467	1	most	most	ADJ
admet-1513	467	2	of	of	ADP
admet-1513	467	3	these	these	DET
admet-1513	467	4	hipsc	hipsc	ADJ
admet-1513	467	5	-	-	PUNCT
admet-1513	467	6	derived	derive	VERB
admet-1513	467	7	organoids	organoid	NOUN
admet-1513	467	8	have	have	VERB
admet-1513	467	9	similarities	similarity	NOUN
admet-1513	467	10	to	to	ADP
admet-1513	467	11	the	the	DET
admet-1513	467	12	fetal	fetal	ADJ
admet-1513	467	13	brain	brain	NOUN
admet-1513	467	14	studies	study	NOUN
admet-1513	467	15	that	that	PRON
admet-1513	467	16	have	have	AUX
admet-1513	467	17	been	be	AUX
admet-1513	467	18	conducted	conduct	VERB
admet-1513	467	19	to	to	PART
admet-1513	467	20	understand	understand	VERB
admet-1513	467	21	the	the	DET
admet-1513	467	22	mechanism	mechanism	NOUN
admet-1513	467	23	of	of	ADP
admet-1513	467	24	fetal	fetal	ADJ
admet-1513	467	25	alcohol	alcohol	NOUN
admet-1513	467	26	spectrum	spectrum	NOUN
admet-1513	467	27	disorders	disorder	NOUN
admet-1513	467	28	[	[	X
admet-1513	467	29	208	208	NUM
admet-1513	467	30	]	]	PUNCT
admet-1513	467	31	.	.	PUNCT
admet-1513	468	1	these	these	DET
admet-1513	468	2	ethanol	ethanol	NOUN
admet-1513	468	3	-	-	PUNCT
admet-1513	468	4	exposed	expose	VERB
admet-1513	468	5	cerebral	cerebral	ADJ
admet-1513	468	6	organoids	organoid	NOUN
admet-1513	468	7	were	be	AUX
admet-1513	468	8	found	find	VERB
admet-1513	468	9	to	to	PART
admet-1513	468	10	have	have	AUX
admet-1513	468	11	increased	increase	VERB
admet-1513	468	12	caspase3	caspase3	NOUN
admet-1513	468	13	activity	activity	NOUN
admet-1513	468	14	and	and	CCONJ
admet-1513	468	15	altered	alter	VERB
admet-1513	468	16	the	the	DET
admet-1513	468	17	morphology	morphology	NOUN
admet-1513	468	18	and	and	CCONJ
admet-1513	468	19	function	function	NOUN
admet-1513	468	20	of	of	ADP
admet-1513	468	21	mitochondria	mitochondria	NOUN
admet-1513	468	22	.	.	PUNCT
admet-1513	469	1	they	they	PRON
admet-1513	469	2	also	also	ADV
admet-1513	469	3	observed	observe	VERB
admet-1513	469	4	that	that	SCONJ
admet-1513	469	5	the	the	DET
admet-1513	469	6	alcohol	alcohol	NOUN
admet-1513	469	7	induction	induction	NOUN
admet-1513	469	8	cases	case	VERB
admet-1513	469	9	more	more	ADJ
admet-1513	469	10	apoptosis	apoptosis	NOUN
admet-1513	469	11	in	in	ADP
admet-1513	469	12	neurons	neuron	NOUN
admet-1513	469	13	than	than	ADP
admet-1513	469	14	astrocytes	astrocyte	NOUN
admet-1513	469	15	.	.	PUNCT
admet-1513	470	1	similarly	similarly	ADV
admet-1513	470	2	,	,	PUNCT
admet-1513	470	3	brain	brain	NOUN
admet-1513	470	4	organoids	organoid	NOUN
admet-1513	470	5	exposed	expose	VERB
admet-1513	470	6	to	to	ADP
admet-1513	470	7	acrylamide	acrylamide	NOUN
admet-1513	470	8	(	(	PUNCT
admet-1513	470	9	a	a	DET
admet-1513	470	10	common	common	ADJ
admet-1513	470	11	food	food	NOUN
admet-1513	470	12	contaminant	contaminant	NOUN
admet-1513	470	13	)	)	PUNCT
admet-1513	470	14	cause	cause	VERB
admet-1513	470	15	a	a	DET
admet-1513	470	16	significant	significant	ADJ
admet-1513	470	17	increase	increase	NOUN
admet-1513	470	18	in	in	ADP
admet-1513	470	19	nuclear	nuclear	ADJ
admet-1513	470	20	factor	factor	NOUN
admet-1513	470	21	erythroid	erythroid	NOUN
admet-1513	470	22	2	2	NUM
admet-1513	470	23	-	-	PUNCT
admet-1513	470	24	related	relate	VERB
admet-1513	470	25	factor	factor	NOUN
admet-1513	470	26	2	2	NUM
admet-1513	470	27	(	(	PUNCT
admet-1513	470	28	nrf2)-mediated	nrf2)-mediate	VERB
admet-1513	470	29	gene	gene	NOUN
admet-1513	470	30	expression	expression	NOUN
admet-1513	470	31	,	,	PUNCT
admet-1513	470	32	induction	induction	NOUN
admet-1513	470	33	of	of	ADP
admet-1513	470	34	cell	cell	NOUN
admet-1513	470	35	apoptosis	apoptosis	NOUN
admet-1513	470	36	,	,	PUNCT
admet-1513	470	37	repression	repression	NOUN
admet-1513	470	38	of	of	ADP
admet-1513	470	39	neuronal	neuronal	ADJ
admet-1513	470	40	differentiation	differentiation	NOUN
admet-1513	470	41	,	,	PUNCT
admet-1513	470	42	and	and	CCONJ
admet-1513	470	43	promotion	promotion	NOUN
admet-1513	470	44	of	of	ADP
admet-1513	470	45	tau	tau	PROPN
admet-1513	470	46	hyperphosphorylation	hyperphosphorylation	NOUN
admet-1513	471	1	[	[	X
admet-1513	471	2	209	209	NUM
admet-1513	471	3	]	]	PUNCT
admet-1513	471	4	.	.	PUNCT
admet-1513	472	1	neurotoxicity	neurotoxicity	NOUN
admet-1513	472	2	assessment	assessment	NOUN
admet-1513	472	3	of	of	ADP
admet-1513	472	4	vincristine	vincristine	NOUN
admet-1513	472	5	on	on	ADP
admet-1513	472	6	brain	brain	NOUN
admet-1513	472	7	organoids	organoid	NOUN
admet-1513	472	8	showed	show	VERB
admet-1513	472	9	dose	dose	NOUN
admet-1513	472	10	-	-	PUNCT
admet-1513	472	11	dependent	dependent	ADJ
admet-1513	472	12	neurotoxicity	neurotoxicity	NOUN
admet-1513	472	13	and	and	CCONJ
admet-1513	472	14	inhibition	inhibition	NOUN
admet-1513	472	15	of	of	ADP
admet-1513	472	16	fibronectin	fibronectin	NOUN
admet-1513	472	17	[	[	X
admet-1513	472	18	210	210	NUM
admet-1513	472	19	]	]	PUNCT
admet-1513	472	20	.	.	PUNCT
admet-1513	473	1	pamies	pamie	NOUN
admet-1513	473	2	and	and	CCONJ
admet-1513	473	3	colleagues	colleague	NOUN
admet-1513	474	1	[	[	X
admet-1513	474	2	211	211	NUM
admet-1513	474	3	]	]	PUNCT
admet-1513	474	4	have	have	AUX
admet-1513	474	5	generated	generate	VERB
admet-1513	474	6	cerebral	cerebral	ADJ
admet-1513	474	7	organoids	organoid	NOUN
admet-1513	474	8	consisting	consist	VERB
admet-1513	474	9	of	of	ADP
admet-1513	474	10	mature	mature	ADJ
admet-1513	474	11	neurons	neuron	NOUN
admet-1513	474	12	and	and	CCONJ
admet-1513	474	13	glial	glial	ADJ
admet-1513	474	14	cells	cell	NOUN
admet-1513	474	15	and	and	CCONJ
admet-1513	474	16	studied	study	VERB
admet-1513	474	17	the	the	DET
admet-1513	474	18	effect	effect	NOUN
admet-1513	474	19	of	of	ADP
admet-1513	474	20	rotenone	rotenone	NOUN
admet-1513	474	21	.	.	PUNCT
admet-1513	475	1	they	they	PRON
admet-1513	475	2	observed	observe	VERB
admet-1513	475	3	the	the	DET
admet-1513	475	4	toxicity	toxicity	NOUN
admet-1513	475	5	of	of	ADP
admet-1513	475	6	rotenone	rotenone	NOUN
admet-1513	475	7	varied	varied	ADJ
admet-1513	475	8	on	on	ADP
admet-1513	475	9	the	the	DET
admet-1513	475	10	differentiation	differentiation	NOUN
admet-1513	475	11	status	status	NOUN
admet-1513	475	12	of	of	ADP
admet-1513	475	13	the	the	DET
admet-1513	475	14	organoids	organoid	NOUN
admet-1513	475	15	.	.	PUNCT
admet-1513	476	1	these	these	DET
admet-1513	476	2	reports	report	NOUN
admet-1513	476	3	suggested	suggest	VERB
admet-1513	476	4	the	the	DET
admet-1513	476	5	scope	scope	NOUN
admet-1513	476	6	of	of	ADP
admet-1513	476	7	3d	3d	PROPN
admet-1513	476	8	organoids	organoid	NOUN
admet-1513	476	9	in	in	ADP
admet-1513	476	10	understanding	understand	VERB
admet-1513	476	11	the	the	DET
admet-1513	476	12	screening	screening	NOUN
admet-1513	476	13	of	of	ADP
admet-1513	476	14	drugs	drug	NOUN
admet-1513	476	15	for	for	ADP
admet-1513	476	16	neurotoxicity	neurotoxicity	NOUN
admet-1513	476	17	.	.	PUNCT
admet-1513	477	1	however	however	ADV
admet-1513	477	2	,	,	PUNCT
admet-1513	477	3	there	there	PRON
admet-1513	477	4	is	be	VERB
admet-1513	477	5	a	a	DET
admet-1513	477	6	requirement	requirement	NOUN
admet-1513	477	7	for	for	ADP
admet-1513	477	8	the	the	DET
admet-1513	477	9	development	development	NOUN
admet-1513	477	10	of	of	ADP
admet-1513	477	11	more	more	ADV
admet-1513	477	12	advanced	advanced	ADJ
admet-1513	477	13	cerebral	cerebral	ADJ
admet-1513	477	14	organoids	organoid	NOUN
admet-1513	477	15	as	as	SCONJ
admet-1513	477	16	there	there	PRON
admet-1513	477	17	are	be	VERB
admet-1513	477	18	several	several	ADJ
admet-1513	477	19	blood	blood	NOUN
admet-1513	477	20	barriers	barrier	NOUN
admet-1513	477	21	involved	involve	VERB
admet-1513	477	22	in	in	ADP
admet-1513	477	23	vivo	vivo	NOUN
admet-1513	477	24	,	,	PUNCT
admet-1513	477	25	such	such	ADJ
admet-1513	477	26	as	as	ADP
admet-1513	477	27	tight	tight	ADJ
admet-1513	477	28	junctions	junction	NOUN
admet-1513	477	29	,	,	PUNCT
admet-1513	477	30	nutrient	nutrient	ADJ
admet-1513	477	31	transporters	transporter	NOUN
admet-1513	477	32	,	,	PUNCT
admet-1513	477	33	and	and	CCONJ
admet-1513	477	34	increased	increase	VERB
admet-1513	477	35	expression	expression	NOUN
admet-1513	477	36	of	of	ADP
admet-1513	477	37	transendothelial	transendothelial	ADJ
admet-1513	477	38	electrical	electrical	ADJ
admet-1513	477	39	resistance	resistance	NOUN
admet-1513	477	40	.	.	PUNCT
admet-1513	478	1	conclusion	conclusion	NOUN
admet-1513	478	2	previously	previously	ADV
admet-1513	478	3	,	,	PUNCT
admet-1513	478	4	adme	adme	NOUN
admet-1513	478	5	-	-	PUNCT
admet-1513	478	6	tox	tox	NOUN
admet-1513	478	7	screening	screening	NOUN
admet-1513	478	8	has	have	AUX
admet-1513	478	9	relied	rely	VERB
admet-1513	478	10	on	on	ADP
admet-1513	478	11	preclinical	preclinical	NOUN
admet-1513	478	12	in	in	ADP
admet-1513	478	13	vivo	vivo	NOUN
admet-1513	478	14	models	model	NOUN
admet-1513	478	15	,	,	PUNCT
admet-1513	478	16	but	but	CCONJ
admet-1513	478	17	because	because	SCONJ
admet-1513	478	18	of	of	ADP
admet-1513	478	19	inter	inter	ADJ
admet-1513	478	20	-	-	ADJ
admet-1513	478	21	species	species	ADJ
admet-1513	478	22	variations	variation	NOUN
admet-1513	478	23	in	in	ADP
admet-1513	478	24	physiology	physiology	NOUN
admet-1513	478	25	and	and	CCONJ
admet-1513	478	26	functions	function	NOUN
admet-1513	478	27	,	,	PUNCT
admet-1513	478	28	the	the	DET
admet-1513	478	29	data	datum	NOUN
admet-1513	478	30	obtained	obtain	VERB
admet-1513	478	31	ca	can	AUX
admet-1513	478	32	n’t	not	PART
admet-1513	478	33	accurately	accurately	ADV
admet-1513	478	34	recapitulate	recapitulate	VERB
admet-1513	478	35	the	the	DET
admet-1513	478	36	mechanism	mechanism	NOUN
admet-1513	478	37	of	of	ADP
admet-1513	478	38	the	the	DET
admet-1513	478	39	adme	adme	NOUN
admet-1513	478	40	-	-	PUNCT
admet-1513	478	41	tox	tox	NOUN
admet-1513	478	42	.	.	PUNCT
admet-1513	479	1	moreover	moreover	ADV
admet-1513	479	2	,	,	PUNCT
admet-1513	479	3	the	the	DET
admet-1513	479	4	preclinical	preclinical	ADJ
admet-1513	479	5	animal	animal	NOUN
admet-1513	479	6	models	model	NOUN
admet-1513	479	7	are	be	AUX
admet-1513	479	8	expensive	expensive	ADJ
admet-1513	479	9	and	and	CCONJ
admet-1513	479	10	time	time	NOUN
admet-1513	479	11	-	-	PUNCT
admet-1513	479	12	consuming	consume	VERB
admet-1513	479	13	and	and	CCONJ
admet-1513	479	14	ca	can	AUX
admet-1513	479	15	n’t	not	PART
admet-1513	479	16	be	be	AUX
admet-1513	479	17	used	use	VERB
admet-1513	479	18	for	for	ADP
admet-1513	479	19	high	high	ADJ
admet-1513	479	20	throughput	throughput	NOUN
admet-1513	479	21	screening	screen	VERB
admet-1513	479	22	particularly	particularly	ADV
admet-1513	479	23	because	because	SCONJ
admet-1513	479	24	of	of	ADP
admet-1513	479	25	ethical	ethical	ADJ
admet-1513	479	26	concerns	concern	NOUN
admet-1513	479	27	.	.	PUNCT
admet-1513	480	1	therefore	therefore	ADV
admet-1513	480	2	in	in	ADP
admet-1513	480	3	vitro	vitro	X
admet-1513	480	4	assays	assay	NOUN
admet-1513	480	5	and	and	CCONJ
admet-1513	480	6	technologies	technology	NOUN
admet-1513	480	7	utilizing	utilize	VERB
admet-1513	480	8	human	human	ADJ
admet-1513	480	9	cells	cell	NOUN
admet-1513	480	10	are	be	AUX
admet-1513	480	11	required	require	VERB
admet-1513	480	12	to	to	PART
admet-1513	480	13	overcome	overcome	VERB
admet-1513	480	14	these	these	DET
admet-1513	480	15	limitations	limitation	NOUN
admet-1513	480	16	and	and	CCONJ
admet-1513	480	17	to	to	PART
admet-1513	480	18	align	align	VERB
admet-1513	480	19	the	the	DET
admet-1513	480	20	concept	concept	NOUN
admet-1513	480	21	of	of	ADP
admet-1513	480	22	the	the	DET
admet-1513	480	23	3rs	3rs	NOUN
admet-1513	480	24	(	(	PUNCT
admet-1513	480	25	replacement	replacement	NOUN
admet-1513	480	26	,	,	PUNCT
admet-1513	480	27	reduction	reduction	NOUN
admet-1513	480	28	and	and	CCONJ
admet-1513	480	29	refinement	refinement	NOUN
admet-1513	480	30	)	)	PUNCT
admet-1513	480	31	.	.	PUNCT
admet-1513	481	1	in	in	ADP
admet-1513	481	2	this	this	DET
admet-1513	481	3	review	review	NOUN
admet-1513	481	4	,	,	PUNCT
admet-1513	481	5	we	we	PRON
admet-1513	481	6	summarized	summarize	VERB
admet-1513	481	7	the	the	DET
admet-1513	481	8	available	available	ADJ
admet-1513	481	9	2d	2d	NOUN
admet-1513	481	10	and	and	CCONJ
admet-1513	481	11	3d	3d	NUM
admet-1513	481	12	in	in	ADP
admet-1513	481	13	vitro	vitro	X
admet-1513	481	14	predictive	predictive	ADJ
admet-1513	481	15	models	model	NOUN
admet-1513	481	16	for	for	ADP
admet-1513	481	17	assessing	assess	VERB
admet-1513	481	18	the	the	DET
admet-1513	481	19	adme	adme	NOUN
admet-1513	481	20	-	-	PUNCT
admet-1513	481	21	tox	tox	NOUN
admet-1513	481	22	screening	screening	NOUN
admet-1513	481	23	.	.	PUNCT
admet-1513	482	1	preclinical	preclinical	ADJ
admet-1513	482	2	2d	2d	NOUN
admet-1513	482	3	in	in	ADP
admet-1513	482	4	vitro	vitro	X
admet-1513	482	5	cell	cell	NOUN
admet-1513	482	6	models	model	NOUN
admet-1513	482	7	are	be	AUX
admet-1513	482	8	necessary	necessary	ADJ
admet-1513	482	9	for	for	ADP
admet-1513	482	10	the	the	DET
admet-1513	482	11	screening	screening	NOUN
admet-1513	482	12	of	of	ADP
admet-1513	482	13	a	a	DET
admet-1513	482	14	large	large	ADJ
admet-1513	482	15	number	number	NOUN
admet-1513	482	16	of	of	ADP
admet-1513	482	17	molecules	molecule	NOUN
admet-1513	482	18	in	in	ADP
admet-1513	482	19	a	a	DET
admet-1513	482	20	cost	cost	NOUN
admet-1513	482	21	-	-	PUNCT
admet-1513	482	22	effective	effective	ADJ
admet-1513	482	23	manner	manner	NOUN
admet-1513	482	24	.	.	PUNCT
admet-1513	483	1	although	although	SCONJ
admet-1513	483	2	the	the	DET
admet-1513	483	3	primary	primary	ADJ
admet-1513	483	4	aim	aim	NOUN
admet-1513	483	5	of	of	ADP
admet-1513	483	6	2d	2d	NUM
admet-1513	483	7	in	in	ADP
admet-1513	483	8	vitro	vitro	X
admet-1513	483	9	assays	assay	NOUN
admet-1513	483	10	is	be	AUX
admet-1513	483	11	to	to	PART
admet-1513	483	12	provide	provide	VERB
admet-1513	483	13	the	the	DET
admet-1513	483	14	prediction	prediction	NOUN
admet-1513	483	15	of	of	ADP
admet-1513	483	16	compound	compound	NOUN
admet-1513	483	17	fate	fate	NOUN
admet-1513	483	18	and	and	CCONJ
admet-1513	483	19	estimate	estimate	VERB
admet-1513	483	20	the	the	DET
admet-1513	483	21	dose	dose	NOUN
admet-1513	483	22	in	in	ADP
admet-1513	483	23	vivo	vivo	ADJ
admet-1513	483	24	equivalent	equivalent	NOUN
admet-1513	483	25	,	,	PUNCT
admet-1513	483	26	still	still	ADV
admet-1513	483	27	there	there	PRON
admet-1513	483	28	are	be	VERB
admet-1513	483	29	a	a	DET
admet-1513	483	30	large	large	ADJ
admet-1513	483	31	number	number	NOUN
admet-1513	483	32	of	of	ADP
admet-1513	483	33	compounds	compound	NOUN
admet-1513	483	34	getting	get	VERB
admet-1513	483	35	attrition	attrition	NOUN
admet-1513	483	36	from	from	ADP
admet-1513	483	37	research	research	NOUN
admet-1513	483	38	programs	program	NOUN
admet-1513	483	39	because	because	SCONJ
admet-1513	483	40	of	of	ADP
admet-1513	483	41	complex	complex	ADJ
admet-1513	483	42	physiology	physiology	NOUN
admet-1513	483	43	.	.	PUNCT
admet-1513	484	1	3d	3d	NOUN
admet-1513	484	2	in	in	ADP
admet-1513	484	3	vitro	vitro	X
admet-1513	484	4	cell	cell	NOUN
admet-1513	484	5	-	-	PUNCT
admet-1513	484	6	based	base	VERB
admet-1513	484	7	assays	assay	NOUN
admet-1513	484	8	have	have	AUX
admet-1513	484	9	provided	provide	VERB
admet-1513	484	10	scope	scope	NOUN
admet-1513	484	11	for	for	ADP
admet-1513	484	12	studying	study	VERB
admet-1513	484	13	the	the	DET
admet-1513	484	14	adem	adem	PROPN
admet-1513	484	15	-	-	PUNCT
admet-1513	484	16	tox	tox	NOUN
admet-1513	484	17	processes	process	NOUN
admet-1513	484	18	because	because	SCONJ
admet-1513	484	19	of	of	ADP
admet-1513	484	20	the	the	DET
admet-1513	484	21	physiological	physiological	ADJ
admet-1513	484	22	similarity	similarity	NOUN
admet-1513	484	23	to	to	ADP
admet-1513	484	24	that	that	PRON
admet-1513	484	25	of	of	ADP
admet-1513	484	26	in	in	ADP
admet-1513	484	27	vivo	vivo	NOUN
admet-1513	484	28	.	.	PUNCT
admet-1513	485	1	majorly	majorly	ADJ
admet-1513	485	2	organoids	organoid	NOUN
admet-1513	485	3	showed	show	VERB
admet-1513	485	4	potential	potential	ADJ
admet-1513	485	5	usefulness	usefulness	NOUN
admet-1513	485	6	in	in	ADP
admet-1513	485	7	toxicology	toxicology	NOUN
admet-1513	485	8	studies	study	NOUN
admet-1513	485	9	,	,	PUNCT
admet-1513	485	10	whereas	whereas	SCONJ
admet-1513	485	11	mps	mp	NOUN
admet-1513	485	12	showed	show	VERB
admet-1513	485	13	potential	potential	NOUN
admet-1513	485	14	in	in	ADP
admet-1513	485	15	studying	study	VERB
admet-1513	485	16	the	the	DET
admet-1513	485	17	adme	adme	NOUN
admet-1513	485	18	process	process	NOUN
admet-1513	485	19	.	.	PUNCT
admet-1513	486	1	still	still	ADV
admet-1513	486	2	,	,	PUNCT
admet-1513	486	3	there	there	PRON
admet-1513	486	4	is	be	VERB
admet-1513	486	5	a	a	DET
admet-1513	486	6	requirement	requirement	NOUN
admet-1513	486	7	for	for	ADP
admet-1513	486	8	improving	improve	VERB
admet-1513	486	9	the	the	DET
admet-1513	486	10	3d	3d	NOUN
admet-1513	486	11	in	in	ADP
admet-1513	486	12	vitro	vitro	X
admet-1513	486	13	models	model	NOUN
admet-1513	486	14	to	to	PART
admet-1513	486	15	mimic	mimic	VERB
admet-1513	486	16	more	more	ADV
admet-1513	486	17	physiologically	physiologically	ADV
admet-1513	486	18	relevant	relevant	ADJ
admet-1513	486	19	human	human	ADJ
admet-1513	486	20	organs	organ	NOUN
admet-1513	486	21	.	.	PUNCT
admet-1513	487	1	further	far	ADV
admet-1513	487	2	,	,	PUNCT
admet-1513	487	3	there	there	PRON
admet-1513	487	4	is	be	VERB
admet-1513	487	5	a	a	DET
admet-1513	487	6	large	large	ADJ
admet-1513	487	7	scope	scope	NOUN
admet-1513	487	8	in	in	ADP
admet-1513	487	9	the	the	DET
admet-1513	487	10	utilization	utilization	NOUN
admet-1513	487	11	of	of	ADP
admet-1513	487	12	mps	mps	PROPN
admet-1513	487	13	technology	technology	NOUN
admet-1513	487	14	where	where	SCONJ
admet-1513	487	15	multiple	multiple	ADJ
admet-1513	487	16	organ	organ	NOUN
admet-1513	487	17	-	-	PUNCT
admet-1513	487	18	on	on	ADP
admet-1513	487	19	-	-	PUNCT
admet-1513	487	20	chip	chip	NOUN
admet-1513	487	21	models	model	NOUN
admet-1513	487	22	can	can	AUX
admet-1513	487	23	be	be	AUX
admet-1513	487	24	interlinked	interlink	VERB
admet-1513	487	25	,	,	PUNCT
admet-1513	487	26	which	which	PRON
admet-1513	487	27	is	be	AUX
admet-1513	487	28	further	far	ADV
admet-1513	487	29	helpful	helpful	ADJ
admet-1513	487	30	in	in	ADP
admet-1513	487	31	studying	study	VERB
admet-1513	487	32	the	the	DET
admet-1513	487	33	mechanism	mechanism	NOUN
admet-1513	487	34	of	of	ADP
admet-1513	487	35	organ	organ	NOUN
admet-1513	487	36	cross	cross	NOUN
admet-1513	487	37	-	-	ADJ
admet-1513	487	38	talk	talk	ADJ
admet-1513	487	39	[	[	X
admet-1513	487	40	212	212	NUM
admet-1513	487	41	-	-	SYM
admet-1513	487	42	214	214	NUM
admet-1513	487	43	]	]	PUNCT
admet-1513	487	44	.	.	PUNCT
admet-1513	488	1	these	these	DET
admet-1513	488	2	initiatives	initiative	NOUN
admet-1513	488	3	will	will	AUX
admet-1513	488	4	enable	enable	VERB
admet-1513	488	5	a	a	DET
admet-1513	488	6	better	well	ADJ
admet-1513	488	7	understanding	understanding	NOUN
admet-1513	488	8	of	of	ADP
admet-1513	488	9	highly	highly	ADV
admet-1513	488	10	predictive	predictive	ADJ
admet-1513	488	11	assays	assay	NOUN
admet-1513	488	12	for	for	ADP
admet-1513	488	13	adme	adme	NOUN
admet-1513	488	14	-	-	PUNCT
admet-1513	488	15	tox	tox	NOUN
admet-1513	488	16	,	,	PUNCT
admet-1513	488	17	and	and	CCONJ
admet-1513	488	18	the	the	DET
admet-1513	488	19	selection	selection	NOUN
admet-1513	488	20	of	of	ADP
admet-1513	488	21	superior	superior	ADJ
admet-1513	488	22	drug	drug	NOUN
admet-1513	488	23	candidates	candidate	NOUN
admet-1513	488	24	during	during	ADP
admet-1513	488	25	the	the	DET
admet-1513	488	26	development	development	NOUN
admet-1513	488	27	process	process	NOUN
admet-1513	488	28	.	.	PUNCT
admet-1513	489	1	admet	admet	PROPN
admet-1513	489	2	&	&	CCONJ
admet-1513	489	3	dmpk	dmpk	PROPN
admet-1513	489	4	11(1	11(1	NUM
admet-1513	489	5	)	)	PUNCT
admet-1513	489	6	(	(	PUNCT
admet-1513	489	7	2023	2023	NUM
admet-1513	489	8	)	)	PUNCT
admet-1513	489	9	1	1	NUM
admet-1513	489	10	-	-	SYM
admet-1513	489	11	32	32	NUM
admet-1513	489	12	2d	2d	NOUN
admet-1513	489	13	and	and	CCONJ
admet-1513	489	14	3d	3d	NOUN
admet-1513	489	15	adme	adme	PROPN
admet-1513	489	16	-	-	PUNCT
admet-1513	489	17	tox	tox	NOUN
admet-1513	489	18	cell	cell	NOUN
admet-1513	489	19	culture	culture	NOUN
admet-1513	489	20	screening	screen	VERB
admet-1513	489	21	:	:	PUNCT
admet-1513	489	22	a	a	DET
admet-1513	489	23	review	review	NOUN
admet-1513	489	24	doi	doi	NOUN
admet-1513	489	25	:	:	PUNCT
admet-1513	489	26	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	489	27	17	17	NUM
admet-1513	489	28	conflict	conflict	NOUN
admet-1513	489	29	of	of	ADP
admet-1513	489	30	interest	interest	NOUN
admet-1513	489	31	:	:	PUNCT
admet-1513	489	32	no	no	DET
admet-1513	489	33	conflicts	conflict	NOUN
admet-1513	489	34	of	of	ADP
admet-1513	489	35	interest	interest	NOUN
admet-1513	489	36	,	,	PUNCT
admet-1513	489	37	financial	financial	ADJ
admet-1513	489	38	or	or	CCONJ
admet-1513	489	39	otherwise	otherwise	ADV
admet-1513	489	40	,	,	PUNCT
admet-1513	489	41	are	be	AUX
admet-1513	489	42	declared	declare	VERB
admet-1513	489	43	by	by	ADP
admet-1513	489	44	the	the	DET
admet-1513	489	45	authors	author	NOUN
admet-1513	489	46	.	.	PUNCT
admet-1513	490	1	references	reference	NOUN
admet-1513	490	2	[	[	X
admet-1513	490	3	1	1	NUM
admet-1513	490	4	]	]	X
admet-1513	490	5	t.t	t.t	PROPN
admet-1513	490	6	.	.	PROPN
admet-1513	490	7	ashburn	ashburn	PROPN
admet-1513	490	8	,	,	PUNCT
admet-1513	490	9	k.b	k.b	PROPN
admet-1513	490	10	.	.	PROPN
admet-1513	490	11	thor	thor	PROPN
admet-1513	490	12	.	.	PUNCT
admet-1513	491	1	drug	drug	NOUN
admet-1513	491	2	repositioning	repositioning	NOUN
admet-1513	491	3	:	:	PUNCT
admet-1513	491	4	identifying	identify	VERB
admet-1513	491	5	and	and	CCONJ
admet-1513	491	6	developing	develop	VERB
admet-1513	491	7	new	new	ADJ
admet-1513	491	8	uses	use	NOUN
admet-1513	491	9	for	for	ADP
admet-1513	491	10	existing	exist	VERB
admet-1513	491	11	drugs	drug	NOUN
admet-1513	491	12	.	.	PUNCT
admet-1513	492	1	nat	nat	PROPN
admet-1513	492	2	.	.	PUNCT
admet-1513	493	1	rev	rev	PROPN
admet-1513	493	2	.	.	PROPN
admet-1513	493	3	drug	drug	NOUN
admet-1513	493	4	discov	discov	NOUN
admet-1513	493	5	.	.	PUNCT
admet-1513	494	1	3	3	NUM
admet-1513	494	2	(	(	PUNCT
admet-1513	494	3	2004	2004	NUM
admet-1513	494	4	)	)	PUNCT
admet-1513	494	5	673	673	NUM
admet-1513	494	6	-	-	SYM
admet-1513	494	7	683	683	NUM
admet-1513	494	8	.	.	PUNCT
admet-1513	495	1	https://doi.org/10.1038/nrd1468	https://doi.org/10.1038/nrd1468	NOUN
admet-1513	495	2	.	.	PUNCT
admet-1513	496	1	[	[	X
admet-1513	496	2	2	2	X
admet-1513	496	3	]	]	PUNCT
admet-1513	496	4	s.	s.	PROPN
admet-1513	496	5	pushpakom	pushpakom	PROPN
admet-1513	496	6	,	,	PUNCT
admet-1513	496	7	f.	f.	PROPN
admet-1513	496	8	iorio	iorio	PROPN
admet-1513	496	9	,	,	PUNCT
admet-1513	496	10	p.a	p.a	PROPN
admet-1513	496	11	.	.	PROPN
admet-1513	496	12	eyers	eyer	NOUN
admet-1513	496	13	,	,	PUNCT
admet-1513	496	14	k.j	k.j	PROPN
admet-1513	496	15	.	.	PROPN
admet-1513	496	16	escott	escott	PROPN
admet-1513	496	17	,	,	PUNCT
admet-1513	496	18	s.	s.	PROPN
admet-1513	496	19	hopper	hopper	PROPN
admet-1513	496	20	,	,	PUNCT
admet-1513	496	21	a.	a.	NOUN
admet-1513	496	22	wells	wells	PROPN
admet-1513	496	23	,	,	PUNCT
admet-1513	496	24	a.	a.	PROPN
admet-1513	496	25	doig	doig	PROPN
admet-1513	496	26	,	,	PUNCT
admet-1513	496	27	t.	t.	PROPN
admet-1513	496	28	guilliams	guilliams	PROPN
admet-1513	496	29	,	,	PUNCT
admet-1513	496	30	j.	j.	PROPN
admet-1513	496	31	latimer	latimer	PROPN
admet-1513	496	32	,	,	PUNCT
admet-1513	496	33	c.	c.	PROPN
admet-1513	496	34	mcnamee	mcnamee	PROPN
admet-1513	496	35	,	,	PUNCT
admet-1513	496	36	a.	a.	PROPN
admet-1513	496	37	norris	norris	PROPN
admet-1513	496	38	,	,	PUNCT
admet-1513	496	39	p.	p.	PROPN
admet-1513	496	40	sanseau	sanseau	PROPN
admet-1513	496	41	,	,	PUNCT
admet-1513	496	42	d.	d.	PROPN
admet-1513	496	43	cavalla	cavalla	PROPN
admet-1513	496	44	,	,	PUNCT
admet-1513	496	45	m.	m.	NOUN
admet-1513	496	46	pirmohamed	pirmohame	VERB
admet-1513	496	47	.	.	PUNCT
admet-1513	497	1	drug	drug	NOUN
admet-1513	497	2	repurposing	repurposing	NOUN
admet-1513	497	3	:	:	PUNCT
admet-1513	497	4	progress	progress	NOUN
admet-1513	497	5	,	,	PUNCT
admet-1513	497	6	challenges	challenge	NOUN
admet-1513	497	7	and	and	CCONJ
admet-1513	497	8	recommendations	recommendation	NOUN
admet-1513	497	9	.	.	PUNCT
admet-1513	498	1	nat	nat	PROPN
admet-1513	498	2	.	.	PUNCT
admet-1513	499	1	rev	rev	PROPN
admet-1513	499	2	.	.	PROPN
admet-1513	499	3	drug	drug	NOUN
admet-1513	499	4	discov	discov	NOUN
admet-1513	499	5	.	.	PUNCT
admet-1513	500	1	18	18	NUM
admet-1513	500	2	(	(	PUNCT
admet-1513	500	3	2019	2019	NUM
admet-1513	500	4	)	)	PUNCT
admet-1513	500	5	41	41	NUM
admet-1513	500	6	-	-	SYM
admet-1513	500	7	58	58	NUM
admet-1513	500	8	.	.	PUNCT
admet-1513	501	1	https://doi.org/10.1038/nrd.2018.168	https://doi.org/10.1038/nrd.2018.168	NOUN
admet-1513	501	2	.	.	PUNCT
admet-1513	502	1	[	[	X
admet-1513	502	2	3	3	NUM
admet-1513	502	3	]	]	X
admet-1513	502	4	s.c	s.c	PROPN
admet-1513	502	5	.	.	PROPN
admet-1513	502	6	gupta	gupta	PROPN
admet-1513	502	7	,	,	PUNCT
admet-1513	502	8	b.	b.	PROPN
admet-1513	502	9	sung	sung	PROPN
admet-1513	502	10	,	,	PUNCT
admet-1513	502	11	s.	s.	PROPN
admet-1513	502	12	prasad	prasad	PROPN
admet-1513	502	13	,	,	PUNCT
admet-1513	502	14	l.j	l.j	PROPN
admet-1513	502	15	.	.	PROPN
admet-1513	502	16	webb	webb	PROPN
admet-1513	502	17	,	,	PUNCT
admet-1513	502	18	b.b	b.b	PROPN
admet-1513	502	19	.	.	PROPN
admet-1513	502	20	aggarwal	aggarwal	PROPN
admet-1513	502	21	.	.	PUNCT
admet-1513	503	1	cancer	cancer	NOUN
admet-1513	503	2	drug	drug	NOUN
admet-1513	503	3	discovery	discovery	NOUN
admet-1513	503	4	by	by	ADP
admet-1513	503	5	repurposing	repurpose	VERB
admet-1513	503	6	:	:	PUNCT
admet-1513	503	7	teaching	teach	VERB
admet-1513	503	8	new	new	ADJ
admet-1513	503	9	tricks	trick	NOUN
admet-1513	503	10	to	to	ADP
admet-1513	503	11	old	old	ADJ
admet-1513	503	12	dogs	dog	NOUN
admet-1513	503	13	.	.	PUNCT
admet-1513	504	1	trends	trend	NOUN
admet-1513	504	2	pharmacol	pharmacol	PROPN
admet-1513	504	3	.	.	PUNCT
admet-1513	505	1	sci	sci	PROPN
admet-1513	505	2	.	.	PROPN
admet-1513	506	1	34	34	NUM
admet-1513	506	2	(	(	PUNCT
admet-1513	506	3	2013	2013	NUM
admet-1513	506	4	)	)	PUNCT
admet-1513	506	5	508	508	NUM
admet-1513	506	6	-	-	SYM
admet-1513	506	7	517	517	NUM
admet-1513	506	8	.	.	PUNCT
admet-1513	507	1	https://doi.org/10.1016/j.tips.2013.06.005	https://doi.org/10.1016/j.tips.2013.06.005	PROPN
admet-1513	507	2	.	.	PUNCT
admet-1513	508	1	[	[	X
admet-1513	508	2	4	4	NUM
admet-1513	508	3	]	]	X
admet-1513	508	4	r.l	r.l	PROPN
admet-1513	508	5	.	.	PROPN
admet-1513	508	6	elliott	elliott	PROPN
admet-1513	508	7	.	.	PUNCT
admet-1513	509	1	four	four	NUM
admet-1513	509	2	lessons	lesson	NOUN
admet-1513	509	3	from	from	ADP
admet-1513	509	4	global	global	ADJ
admet-1513	509	5	health	health	NOUN
admet-1513	509	6	drug	drug	NOUN
admet-1513	509	7	discovery	discovery	NOUN
admet-1513	509	8	:	:	PUNCT
admet-1513	509	9	medicine	medicine	NOUN
admet-1513	509	10	for	for	ADP
admet-1513	509	11	an	an	DET
admet-1513	509	12	ailing	ail	VERB
admet-1513	509	13	industry	industry	NOUN
admet-1513	509	14	.	.	PUNCT
admet-1513	510	1	acs	acs	PROPN
admet-1513	510	2	med	med	PROPN
admet-1513	510	3	.	.	PUNCT
admet-1513	510	4	chem	chem	PROPN
admet-1513	510	5	.	.	PUNCT
admet-1513	511	1	lett	lett	PROPN
admet-1513	511	2	.	.	PROPN
admet-1513	512	1	3	3	NUM
admet-1513	512	2	(	(	PUNCT
admet-1513	512	3	2012	2012	NUM
admet-1513	512	4	)	)	PUNCT
admet-1513	512	5	688	688	NUM
admet-1513	512	6	-	-	SYM
admet-1513	512	7	690	690	NUM
admet-1513	512	8	.	.	PUNCT
admet-1513	513	1	https://doi.org/10.1021/ml3002105	https://doi.org/10.1021/ml3002105	NOUN
admet-1513	513	2	.	.	PUNCT
admet-1513	514	1	[	[	X
admet-1513	514	2	5	5	NUM
admet-1513	514	3	]	]	PUNCT
admet-1513	514	4	a.	a.	NOUN
admet-1513	514	5	fedi	fedi	PROPN
admet-1513	514	6	,	,	PUNCT
admet-1513	514	7	c.	c.	PROPN
admet-1513	514	8	vitale	vitale	PROPN
admet-1513	514	9	,	,	PUNCT
admet-1513	514	10	g.	g.	PROPN
admet-1513	514	11	ponschin	ponschin	PROPN
admet-1513	514	12	,	,	PUNCT
admet-1513	514	13	s.	s.	PROPN
admet-1513	514	14	ayehunie	ayehunie	PROPN
admet-1513	514	15	,	,	PUNCT
admet-1513	514	16	m.	m.	NOUN
admet-1513	514	17	fato	fato	PROPN
admet-1513	514	18	,	,	PUNCT
admet-1513	514	19	s.	s.	PROPN
admet-1513	514	20	scaglione	scaglione	PROPN
admet-1513	514	21	.	.	PUNCT
admet-1513	515	1	in	in	ADP
admet-1513	515	2	vitro	vitro	X
admet-1513	515	3	models	model	NOUN
admet-1513	515	4	replicating	replicate	VERB
admet-1513	515	5	the	the	DET
admet-1513	515	6	human	human	ADJ
admet-1513	515	7	intestinal	intestinal	ADJ
admet-1513	515	8	epithelium	epithelium	NOUN
admet-1513	515	9	for	for	ADP
admet-1513	515	10	absorption	absorption	NOUN
admet-1513	515	11	and	and	CCONJ
admet-1513	515	12	metabolism	metabolism	NOUN
admet-1513	515	13	studies	study	NOUN
admet-1513	515	14	:	:	PUNCT
admet-1513	515	15	a	a	DET
admet-1513	515	16	systematic	systematic	ADJ
admet-1513	515	17	review	review	NOUN
admet-1513	515	18	.	.	PUNCT
admet-1513	516	1	j.	j.	PROPN
admet-1513	516	2	control	control	PROPN
admet-1513	516	3	.	.	PUNCT
admet-1513	517	1	release	release	VERB
admet-1513	517	2	335	335	NUM
admet-1513	517	3	(	(	PUNCT
admet-1513	517	4	2021	2021	NUM
admet-1513	517	5	)	)	PUNCT
admet-1513	517	6	247	247	NUM
admet-1513	517	7	-	-	SYM
admet-1513	517	8	268	268	NUM
admet-1513	517	9	.	.	PUNCT
admet-1513	518	1	https://doi.org/10.1016/j.jconrel.2021.05.028	https://doi.org/10.1016/j.jconrel.2021.05.028	PROPN
admet-1513	518	2	.	.	PUNCT
admet-1513	519	1	[	[	X
admet-1513	519	2	6	6	NUM
admet-1513	519	3	]	]	PUNCT
admet-1513	519	4	l.	l.	PROPN
admet-1513	519	5	meigs	meigs	PROPN
admet-1513	519	6	,	,	PUNCT
admet-1513	519	7	l.	l.	PROPN
admet-1513	519	8	smirnova	smirnova	PROPN
admet-1513	519	9	,	,	PUNCT
admet-1513	519	10	c.	c.	PROPN
admet-1513	519	11	rovida	rovida	PROPN
admet-1513	519	12	,	,	PUNCT
admet-1513	519	13	m.	m.	NOUN
admet-1513	519	14	leist	leist	NOUN
admet-1513	519	15	,	,	PUNCT
admet-1513	519	16	t.	t.	PROPN
admet-1513	519	17	hartung	hartung	PROPN
admet-1513	519	18	.	.	PUNCT
admet-1513	519	19	animal	animal	NOUN
admet-1513	519	20	testing	testing	NOUN
admet-1513	519	21	and	and	CCONJ
admet-1513	519	22	its	its	PRON
admet-1513	519	23	alternatives	alternative	NOUN
admet-1513	519	24	the	the	DET
admet-1513	519	25	most	most	ADV
admet-1513	519	26	important	important	ADJ
admet-1513	519	27	omics	omic	NOUN
admet-1513	519	28	is	be	AUX
admet-1513	519	29	economics	economic	NOUN
admet-1513	519	30	.	.	PUNCT
admet-1513	520	1	altex	altex	PROPN
admet-1513	520	2	35	35	NUM
admet-1513	520	3	(	(	PUNCT
admet-1513	520	4	2018	2018	NUM
admet-1513	520	5	)	)	PUNCT
admet-1513	520	6	275	275	NUM
admet-1513	520	7	-	-	SYM
admet-1513	520	8	305	305	NUM
admet-1513	520	9	.	.	PUNCT
admet-1513	520	10	https://doi.org/10.14573/altex.1807041	https://doi.org/10.14573/altex.1807041	NOUN
admet-1513	520	11	.	.	PUNCT
admet-1513	521	1	[	[	X
admet-1513	521	2	7	7	X
admet-1513	521	3	]	]	X
admet-1513	521	4	k.	k.	PROPN
admet-1513	521	5	fabre	fabre	PROPN
admet-1513	521	6	,	,	PUNCT
admet-1513	521	7	b.	b.	PROPN
admet-1513	521	8	berridge	berridge	PROPN
admet-1513	521	9	,	,	PUNCT
admet-1513	521	10	w.r	w.r	PROPN
admet-1513	521	11	.	.	NOUN
admet-1513	521	12	proctor	proctor	PROPN
admet-1513	521	13	,	,	PUNCT
admet-1513	521	14	s.	s.	PROPN
admet-1513	521	15	ralston	ralston	PROPN
admet-1513	521	16	,	,	PUNCT
admet-1513	521	17	y.	y.	PROPN
admet-1513	521	18	will	will	AUX
admet-1513	521	19	,	,	PUNCT
admet-1513	521	20	s.w	s.w	PROPN
admet-1513	521	21	.	.	PROPN
admet-1513	521	22	baran	baran	PROPN
admet-1513	521	23	,	,	PUNCT
admet-1513	521	24	g.	g.	PROPN
admet-1513	521	25	yoder	yoder	PROPN
admet-1513	521	26	,	,	PUNCT
admet-1513	521	27	t.r	t.r	PROPN
admet-1513	521	28	.	.	PROPN
admet-1513	521	29	van	van	PROPN
admet-1513	521	30	vleet	vleet	PROPN
admet-1513	521	31	.	.	PUNCT
admet-1513	522	1	introduction	introduction	NOUN
admet-1513	522	2	to	to	ADP
admet-1513	522	3	a	a	DET
admet-1513	522	4	manuscript	manuscript	NOUN
admet-1513	522	5	series	series	NOUN
admet-1513	522	6	on	on	ADP
admet-1513	522	7	the	the	DET
admet-1513	522	8	characterization	characterization	NOUN
admet-1513	522	9	and	and	CCONJ
admet-1513	522	10	use	use	NOUN
admet-1513	522	11	of	of	ADP
admet-1513	522	12	microphysiological	microphysiological	ADJ
admet-1513	522	13	systems	system	NOUN
admet-1513	522	14	(	(	PUNCT
admet-1513	522	15	mps	mps	PROPN
admet-1513	522	16	)	)	PUNCT
admet-1513	522	17	in	in	ADP
admet-1513	522	18	pharmaceutical	pharmaceutical	ADJ
admet-1513	522	19	safety	safety	NOUN
admet-1513	522	20	and	and	CCONJ
admet-1513	522	21	adme	adme	NOUN
admet-1513	522	22	applications	application	NOUN
admet-1513	522	23	.	.	PUNCT
admet-1513	523	1	lab	lab	NOUN
admet-1513	523	2	chip	chip	NOUN
admet-1513	523	3	20	20	NUM
admet-1513	523	4	(	(	PUNCT
admet-1513	523	5	2020	2020	NUM
admet-1513	523	6	)	)	PUNCT
admet-1513	523	7	1049	1049	NUM
admet-1513	523	8	-	-	SYM
admet-1513	523	9	1057	1057	NUM
admet-1513	523	10	.	.	PUNCT
admet-1513	524	1	https://doi.org/10.1039/c9lc01168d	https://doi.org/10.1039/c9lc01168d	PROPN
admet-1513	524	2	.	.	PUNCT
admet-1513	525	1	[	[	X
admet-1513	525	2	8	8	NUM
admet-1513	525	3	]	]	X
admet-1513	525	4	r.	r.	NOUN
admet-1513	525	5	negoro	negoro	PROPN
admet-1513	525	6	,	,	PUNCT
admet-1513	525	7	k.	k.	PROPN
admet-1513	525	8	takayama	takayama	PROPN
admet-1513	525	9	,	,	PUNCT
admet-1513	525	10	y.	y.	PROPN
admet-1513	525	11	nagamoto	nagamoto	PROPN
admet-1513	525	12	,	,	PUNCT
admet-1513	525	13	f.	f.	PROPN
admet-1513	525	14	sakurai	sakurai	PROPN
admet-1513	525	15	,	,	PUNCT
admet-1513	525	16	m.	m.	NOUN
admet-1513	525	17	tachibana	tachibana	PROPN
admet-1513	525	18	,	,	PUNCT
admet-1513	525	19	h.	h.	PROPN
admet-1513	525	20	mizuguchi	mizuguchi	PROPN
admet-1513	525	21	.	.	PUNCT
admet-1513	526	1	modeling	modeling	NOUN
admet-1513	526	2	of	of	ADP
admet-1513	526	3	drugmediated	drugmediate	VERB
admet-1513	526	4	cyp3a4	cyp3a4	NOUN
admet-1513	526	5	induction	induction	NOUN
admet-1513	526	6	by	by	ADP
admet-1513	526	7	using	use	VERB
admet-1513	526	8	human	human	ADJ
admet-1513	526	9	ips	ip	NOUN
admet-1513	526	10	cell	cell	NOUN
admet-1513	526	11	-	-	PUNCT
admet-1513	526	12	derived	derive	VERB
admet-1513	526	13	enterocyte	enterocyte	NOUN
admet-1513	526	14	-	-	PUNCT
admet-1513	526	15	like	like	ADJ
admet-1513	526	16	cells	cell	NOUN
admet-1513	526	17	.	.	PUNCT
admet-1513	527	1	biochem	biochem	PROPN
admet-1513	527	2	.	.	PUNCT
admet-1513	528	1	biophys	biophy	NOUN
admet-1513	528	2	.	.	PUNCT
admet-1513	529	1	res	re	NOUN
admet-1513	529	2	.	.	PUNCT
admet-1513	529	3	commun	commun	PROPN
admet-1513	529	4	.	.	PUNCT
admet-1513	530	1	472	472	NUM
admet-1513	530	2	(	(	PUNCT
admet-1513	530	3	2016	2016	NUM
admet-1513	530	4	)	)	PUNCT
admet-1513	530	5	631	631	NUM
admet-1513	530	6	-	-	SYM
admet-1513	530	7	636	636	NUM
admet-1513	530	8	.	.	PUNCT
admet-1513	531	1	https://doi.org/10.1016/j.bbrc.2016.03.012	https://doi.org/10.1016/j.bbrc.2016.03.012	ADV
admet-1513	531	2	.	.	PUNCT
admet-1513	532	1	[	[	X
admet-1513	532	2	9	9	NUM
admet-1513	532	3	]	]	PUNCT
admet-1513	532	4	l.	l.	PROPN
admet-1513	532	5	romero	romero	PROPN
admet-1513	532	6	,	,	PUNCT
admet-1513	532	7	j.m	j.m	PROPN
admet-1513	532	8	.	.	PROPN
admet-1513	532	9	vela	vela	PROPN
admet-1513	532	10	.	.	PUNCT
admet-1513	533	1	alternative	alternative	ADJ
admet-1513	533	2	models	model	NOUN
admet-1513	533	3	in	in	ADP
admet-1513	533	4	drug	drug	NOUN
admet-1513	533	5	discovery	discovery	NOUN
admet-1513	533	6	and	and	CCONJ
admet-1513	533	7	development	development	NOUN
admet-1513	533	8	part	part	NOUN
admet-1513	534	1	i	i	NOUN
admet-1513	534	2	:	:	PUNCT
admet-1513	534	3	in	in	ADP
admet-1513	534	4	silico	silico	NOUN
admet-1513	534	5	and	and	CCONJ
admet-1513	534	6	in	in	ADP
admet-1513	534	7	vitro	vitro	X
admet-1513	534	8	models	model	NOUN
admet-1513	534	9	.	.	PUNCT
admet-1513	535	1	in	in	ADP
admet-1513	535	2	vivo	vivo	NOUN
admet-1513	535	3	models	model	NOUN
admet-1513	535	4	for	for	ADP
admet-1513	535	5	drug	drug	NOUN
admet-1513	535	6	discovery	discovery	NOUN
admet-1513	535	7	,	,	PUNCT
admet-1513	535	8	john	john	PROPN
admet-1513	535	9	wiley	wiley	PROPN
admet-1513	535	10	&	&	CCONJ
admet-1513	535	11	sons	son	NOUN
admet-1513	535	12	,	,	PUNCT
admet-1513	535	13	2014	2014	NUM
admet-1513	535	14	,	,	PUNCT
admet-1513	535	15	p.	p.	NOUN
admet-1513	535	16	27	27	NUM
admet-1513	535	17	-	-	SYM
admet-1513	535	18	58	58	NUM
admet-1513	535	19	.	.	PUNCT
admet-1513	536	1	[	[	X
admet-1513	536	2	10	10	NUM
admet-1513	536	3	]	]	X
admet-1513	536	4	e.	e.	PROPN
admet-1513	536	5	berggren	berggren	PROPN
admet-1513	536	6	,	,	PUNCT
admet-1513	536	7	a.	a.	PROPN
admet-1513	536	8	white	white	PROPN
admet-1513	536	9	,	,	PUNCT
admet-1513	536	10	g.	g.	PROPN
admet-1513	536	11	ouedraogo	ouedraogo	PROPN
admet-1513	536	12	,	,	PUNCT
admet-1513	536	13	a.	a.	NOUN
admet-1513	536	14	paini	paini	PROPN
admet-1513	536	15	,	,	PUNCT
admet-1513	536	16	a.n	a.n	PROPN
admet-1513	536	17	.	.	PROPN
admet-1513	536	18	richarz	richarz	PROPN
admet-1513	536	19	,	,	PUNCT
admet-1513	536	20	f.y	f.y	PROPN
admet-1513	536	21	.	.	PROPN
admet-1513	536	22	bois	bois	PROPN
admet-1513	536	23	,	,	PUNCT
admet-1513	536	24	t.	t.	PROPN
admet-1513	536	25	exner	exner	PROPN
admet-1513	536	26	,	,	PUNCT
admet-1513	536	27	s.	s.	PROPN
admet-1513	536	28	leite	leite	PROPN
admet-1513	536	29	,	,	PUNCT
admet-1513	536	30	l.a.v	l.a.v	NOUN
admet-1513	536	31	.	.	PUNCT
admet-1513	537	1	grunsven	grunsven	VERB
admet-1513	537	2	,	,	PUNCT
admet-1513	537	3	a.	a.	NOUN
admet-1513	537	4	worth	worth	NOUN
admet-1513	537	5	,	,	PUNCT
admet-1513	537	6	c.	c.	PROPN
admet-1513	537	7	mahony	mahony	PROPN
admet-1513	537	8	.	.	PUNCT
admet-1513	538	1	ab	ab	PROPN
admet-1513	538	2	initio	initio	PROPN
admet-1513	538	3	chemical	chemical	PROPN
admet-1513	538	4	safety	safety	PROPN
admet-1513	538	5	assessment	assessment	NOUN
admet-1513	538	6	:	:	PUNCT
admet-1513	538	7	a	a	DET
admet-1513	538	8	workflow	workflow	NOUN
admet-1513	538	9	based	base	VERB
admet-1513	538	10	on	on	ADP
admet-1513	538	11	exposure	exposure	NOUN
admet-1513	538	12	considerations	consideration	NOUN
admet-1513	538	13	and	and	CCONJ
admet-1513	538	14	non	non	ADJ
admet-1513	538	15	-	-	ADJ
admet-1513	538	16	animal	animal	ADJ
admet-1513	538	17	methods	method	NOUN
admet-1513	538	18	.	.	PUNCT
admet-1513	539	1	comput	comput	NOUN
admet-1513	539	2	.	.	PUNCT
admet-1513	540	1	toxicol	toxicol	PROPN
admet-1513	540	2	.	.	PUNCT
admet-1513	541	1	4	4	NUM
admet-1513	541	2	(	(	PUNCT
admet-1513	541	3	2017	2017	NUM
admet-1513	541	4	)	)	PUNCT
admet-1513	541	5	31	31	NUM
admet-1513	541	6	-	-	SYM
admet-1513	541	7	44	44	NUM
admet-1513	541	8	.	.	PUNCT
admet-1513	542	1	https://doi.org/10.1016/j.comtox.2017.10.001	https://doi.org/10.1016/j.comtox.2017.10.001	PROPN
admet-1513	542	2	.	.	PUNCT
admet-1513	543	1	[	[	X
admet-1513	543	2	11	11	NUM
admet-1513	543	3	]	]	X
admet-1513	543	4	t.d	t.d	PROPN
admet-1513	543	5	.	.	PROPN
admet-1513	543	6	chung	chung	PROPN
admet-1513	543	7	,	,	PUNCT
admet-1513	543	8	d.b	d.b	PROPN
admet-1513	543	9	.	.	PROPN
admet-1513	543	10	terry	terry	PROPN
admet-1513	543	11	,	,	PUNCT
admet-1513	543	12	l.h	l.h	PROPN
admet-1513	543	13	.	.	PROPN
admet-1513	543	14	smith	smith	PROPN
admet-1513	543	15	.	.	PUNCT
admet-1513	544	1	in	in	ADP
admet-1513	544	2	vitro	vitro	X
admet-1513	544	3	and	and	CCONJ
admet-1513	544	4	in	in	ADP
admet-1513	544	5	vivo	vivo	ADJ
admet-1513	544	6	assessment	assessment	NOUN
admet-1513	544	7	of	of	ADP
admet-1513	544	8	adme	adme	NOUN
admet-1513	544	9	and	and	CCONJ
admet-1513	544	10	pk	pk	NOUN
admet-1513	544	11	properties	property	NOUN
admet-1513	544	12	during	during	ADP
admet-1513	544	13	lead	lead	ADJ
admet-1513	544	14	selection	selection	NOUN
admet-1513	544	15	and	and	CCONJ
admet-1513	544	16	lead	lead	VERB
admet-1513	544	17	optimization	optimization	NOUN
admet-1513	544	18	–	–	PUNCT
admet-1513	544	19	guidelines	guideline	NOUN
admet-1513	544	20	,	,	PUNCT
admet-1513	544	21	benchmarks	benchmark	NOUN
admet-1513	544	22	and	and	CCONJ
admet-1513	544	23	rules	rule	NOUN
admet-1513	544	24	of	of	ADP
admet-1513	544	25	thumb	thumb	NOUN
admet-1513	544	26	.	.	PUNCT
admet-1513	545	1	assay	assay	NOUN
admet-1513	545	2	guidance	guidance	NOUN
admet-1513	545	3	manual	manual	NOUN
admet-1513	545	4	[	[	X
admet-1513	545	5	internet	internet	NOUN
admet-1513	545	6	]	]	X
admet-1513	545	7	,	,	PUNCT
admet-1513	545	8	bethesda	bethesda	PROPN
admet-1513	545	9	(	(	PUNCT
admet-1513	545	10	md	md	PROPN
admet-1513	545	11	):	):	PUNCT
admet-1513	545	12	eli	eli	PROPN
admet-1513	545	13	lilly	lilly	PROPN
admet-1513	545	14	&	&	CCONJ
admet-1513	545	15	company	company	PROPN
admet-1513	545	16	and	and	CCONJ
admet-1513	545	17	the	the	DET
admet-1513	545	18	national	national	ADJ
admet-1513	545	19	center	center	NOUN
admet-1513	545	20	for	for	ADP
admet-1513	545	21	advancing	advance	VERB
admet-1513	545	22	translational	translational	ADJ
admet-1513	545	23	sciences	science	NOUN
admet-1513	545	24	,	,	PUNCT
admet-1513	545	25	2015	2015	NUM
admet-1513	545	26	.	.	PUNCT
admet-1513	546	1	[	[	X
admet-1513	546	2	12	12	NUM
admet-1513	546	3	]	]	PUNCT
admet-1513	546	4	a.	a.	NOUN
admet-1513	546	5	astashkina	astashkina	PROPN
admet-1513	546	6	,	,	PUNCT
admet-1513	546	7	b.	b.	PROPN
admet-1513	546	8	mann	mann	PROPN
admet-1513	546	9	,	,	PUNCT
admet-1513	546	10	d.w	d.w	PROPN
admet-1513	546	11	.	.	PROPN
admet-1513	546	12	grainger	grainger	PROPN
admet-1513	546	13	.	.	PUNCT
admet-1513	547	1	a	a	DET
admet-1513	547	2	critical	critical	ADJ
admet-1513	547	3	evaluation	evaluation	NOUN
admet-1513	547	4	of	of	ADP
admet-1513	547	5	in	in	ADP
admet-1513	547	6	vitro	vitro	X
admet-1513	547	7	cell	cell	NOUN
admet-1513	547	8	culture	culture	NOUN
admet-1513	547	9	models	model	NOUN
admet-1513	547	10	for	for	ADP
admet-1513	547	11	highthroughput	highthroughput	ADJ
admet-1513	547	12	drug	drug	NOUN
admet-1513	547	13	screening	screening	NOUN
admet-1513	547	14	and	and	CCONJ
admet-1513	547	15	toxicity	toxicity	NOUN
admet-1513	547	16	.	.	PUNCT
admet-1513	548	1	pharmacol	pharmacol	PROPN
admet-1513	548	2	.	.	PUNCT
admet-1513	549	1	ther	ther	PROPN
admet-1513	549	2	.	.	PUNCT
admet-1513	550	1	134	134	NUM
admet-1513	550	2	(	(	PUNCT
admet-1513	550	3	2012	2012	NUM
admet-1513	550	4	)	)	PUNCT
admet-1513	550	5	82	82	NUM
admet-1513	550	6	-	-	SYM
admet-1513	550	7	106	106	NUM
admet-1513	550	8	.	.	PUNCT
admet-1513	551	1	https://doi.org/10.1016/j.pharmthera.2012.01.001	https://doi.org/10.1016/j.pharmthera.2012.01.001	PROPN
admet-1513	551	2	.	.	PUNCT
admet-1513	552	1	[	[	X
admet-1513	552	2	13	13	NUM
admet-1513	552	3	]	]	SYM
admet-1513	552	4	p.r	p.r	PROPN
admet-1513	552	5	.	.	PROPN
admet-1513	552	6	kiela	kiela	PROPN
admet-1513	552	7	,	,	PUNCT
admet-1513	552	8	f.k	f.k	PROPN
admet-1513	552	9	.	.	PROPN
admet-1513	552	10	ghishan	ghishan	PROPN
admet-1513	552	11	.	.	PUNCT
admet-1513	553	1	physiology	physiology	NOUN
admet-1513	553	2	of	of	ADP
admet-1513	553	3	intestinal	intestinal	ADJ
admet-1513	553	4	absorption	absorption	NOUN
admet-1513	553	5	and	and	CCONJ
admet-1513	553	6	secretion	secretion	NOUN
admet-1513	553	7	.	.	PUNCT
admet-1513	554	1	best	good	ADJ
admet-1513	554	2	pract	pract	PROPN
admet-1513	554	3	.	.	PUNCT
admet-1513	555	1	res	re	NOUN
admet-1513	555	2	.	.	PUNCT
admet-1513	556	1	clin	clin	PROPN
admet-1513	556	2	.	.	PUNCT
admet-1513	557	1	gastroenterol	gastroenterol	PROPN
admet-1513	557	2	.	.	PUNCT
admet-1513	558	1	30	30	NUM
admet-1513	558	2	(	(	PUNCT
admet-1513	558	3	2016	2016	NUM
admet-1513	558	4	)	)	PUNCT
admet-1513	558	5	145	145	NUM
admet-1513	558	6	-	-	SYM
admet-1513	558	7	159	159	NUM
admet-1513	558	8	.	.	PUNCT
admet-1513	559	1	https://doi.org/10.1016/j.bpg.2016.02.007	https://doi.org/10.1016/j.bpg.2016.02.007	NOUN
admet-1513	559	2	.	.	PUNCT
admet-1513	560	1	[	[	X
admet-1513	560	2	14	14	NUM
admet-1513	560	3	]	]	PUNCT
admet-1513	560	4	m.	m.	NOUN
admet-1513	560	5	herath	herath	PROPN
admet-1513	560	6	,	,	PUNCT
admet-1513	560	7	s.	s.	PROPN
admet-1513	560	8	hosie	hosie	PROPN
admet-1513	560	9	,	,	PUNCT
admet-1513	560	10	j.c	j.c	PROPN
admet-1513	560	11	.	.	PROPN
admet-1513	560	12	bornstein	bornstein	PROPN
admet-1513	560	13	,	,	PUNCT
admet-1513	560	14	a.e	a.e	PROPN
admet-1513	560	15	.	.	PROPN
admet-1513	560	16	franks	frank	NOUN
admet-1513	560	17	,	,	PUNCT
admet-1513	560	18	e.l	e.l	PROPN
admet-1513	560	19	.	.	PROPN
admet-1513	560	20	hill	hill	PROPN
admet-1513	560	21	-	-	PUNCT
admet-1513	560	22	yardin	yardin	NOUN
admet-1513	560	23	.	.	PUNCT
admet-1513	561	1	the	the	DET
admet-1513	561	2	role	role	NOUN
admet-1513	561	3	of	of	ADP
admet-1513	561	4	the	the	DET
admet-1513	561	5	gastrointestinal	gastrointestinal	ADJ
admet-1513	561	6	mucus	mucus	NOUN
admet-1513	561	7	system	system	NOUN
admet-1513	561	8	in	in	ADP
admet-1513	561	9	intestinal	intestinal	ADJ
admet-1513	561	10	homeostasis	homeostasis	NOUN
admet-1513	561	11	:	:	PUNCT
admet-1513	561	12	implications	implication	NOUN
admet-1513	561	13	for	for	ADP
admet-1513	561	14	neurological	neurological	ADJ
admet-1513	561	15	disorders	disorder	NOUN
admet-1513	561	16	.	.	PUNCT
admet-1513	562	1	front	front	ADJ
admet-1513	562	2	.	.	PUNCT
admet-1513	563	1	cell	cell	NOUN
admet-1513	563	2	infect	infect	NOUN
admet-1513	563	3	.	.	PUNCT
admet-1513	564	1	microbiol	microbiol	PROPN
admet-1513	564	2	.	.	PUNCT
admet-1513	565	1	10	10	NUM
admet-1513	565	2	(	(	PUNCT
admet-1513	565	3	2020	2020	NUM
admet-1513	565	4	)	)	PUNCT
admet-1513	565	5	248	248	NUM
admet-1513	565	6	.	.	PUNCT
admet-1513	566	1	https://doi.org/10.3389/fcimb.2020.00248	https://doi.org/10.3389/fcimb.2020.00248	PROPN
admet-1513	566	2	.	.	PUNCT
admet-1513	566	3	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	566	4	https://doi.org/10.1038/nrd1468	https://doi.org/10.1038/nrd1468	PROPN
admet-1513	566	5	https://doi.org/10.1038/nrd.2018.168	https://doi.org/10.1038/nrd.2018.168	NOUN
admet-1513	566	6	https://doi.org/10.1038/nrd.2018.168	https://doi.org/10.1038/nrd.2018.168	NOUN
admet-1513	566	7	https://doi.org/10.1016/j.tips.2013.06.005	https://doi.org/10.1016/j.tips.2013.06.005	VERB
admet-1513	566	8	https://doi.org/10.1016/j.tips.2013.06.005	https://doi.org/10.1016/j.tips.2013.06.005	PRON
admet-1513	566	9	https://doi.org/10.1021/ml3002105	https://doi.org/10.1021/ml3002105	ADJ
admet-1513	566	10	https://doi.org/10.1016/j.jconrel.2021.05.028	https://doi.org/10.1016/j.jconrel.2021.05.028	ADJ
admet-1513	566	11	https://doi.org/10.14573/altex.1807041	https://doi.org/10.14573/altex.1807041	NOUN
admet-1513	566	12	https://doi.org/10.1039/c9lc01168d	https://doi.org/10.1039/c9lc01168d	PROPN
admet-1513	566	13	https://doi.org/10.1016/j.bbrc.2016.03.012	https://doi.org/10.1016/j.bbrc.2016.03.012	PROPN
admet-1513	566	14	https://doi.org/10.1016/j.comtox.2017.10.001	https://doi.org/10.1016/j.comtox.2017.10.001	PROPN
admet-1513	566	15	https://doi.org/10.1016/j.comtox.2017.10.001	https://doi.org/10.1016/j.comtox.2017.10.001	PROPN
admet-1513	566	16	https://doi.org/10.1016/j.pharmthera.2012.01.001	https://doi.org/10.1016/j.pharmthera.2012.01.001	VERB
admet-1513	566	17	https://doi.org/10.1016/j.pharmthera.2012.01.001	https://doi.org/10.1016/j.pharmthera.2012.01.001	VERB
admet-1513	566	18	https://doi.org/10.1016/j.bpg.2016.02.007	https://doi.org/10.1016/j.bpg.2016.02.007	NOUN
admet-1513	566	19	https://doi.org/10.3389/fcimb.2020.00248	https://doi.org/10.3389/fcimb.2020.00248	PROPN
admet-1513	566	20	venkatesh	venkatesh	PROPN
admet-1513	566	21	chunduri	chunduri	NOUN
admet-1513	566	22	and	and	CCONJ
admet-1513	566	23	srinivas	srinivas	PROPN
admet-1513	566	24	maddi	maddi	PROPN
admet-1513	566	25	admet	admet	PROPN
admet-1513	566	26	&	&	CCONJ
admet-1513	566	27	dmpk	dmpk	PROPN
admet-1513	566	28	11(1	11(1	NUM
admet-1513	566	29	)	)	PUNCT
admet-1513	566	30	(	(	PUNCT
admet-1513	566	31	2023	2023	NUM
admet-1513	566	32	)	)	PUNCT
admet-1513	566	33	1	1	NUM
admet-1513	566	34	-	-	SYM
admet-1513	566	35	32	32	NUM
admet-1513	566	36	18	18	NUM
admet-1513	567	1	[	[	X
admet-1513	567	2	15	15	NUM
admet-1513	567	3	]	]	PUNCT
admet-1513	567	4	k.	k.	PROPN
admet-1513	567	5	pocock	pocock	PROPN
admet-1513	567	6	,	,	PUNCT
admet-1513	567	7	l.	l.	PROPN
admet-1513	567	8	delon	delon	PROPN
admet-1513	567	9	,	,	PUNCT
admet-1513	567	10	v.	v.	PROPN
admet-1513	567	11	bala	bala	PROPN
admet-1513	567	12	,	,	PUNCT
admet-1513	567	13	s.	s.	PROPN
admet-1513	567	14	rao	rao	PROPN
admet-1513	567	15	,	,	PUNCT
admet-1513	567	16	c.	c.	PROPN
admet-1513	567	17	priest	priest	PROPN
admet-1513	567	18	,	,	PUNCT
admet-1513	567	19	c.	c.	PROPN
admet-1513	567	20	prestidge	prestidge	PROPN
admet-1513	567	21	,	,	PUNCT
admet-1513	567	22	b.	b.	PROPN
admet-1513	567	23	thierry	thierry	PROPN
admet-1513	567	24	.	.	PUNCT
admet-1513	568	1	intestine	intestine	VERB
admet-1513	568	2	-	-	PUNCT
admet-1513	568	3	on	on	ADP
admet-1513	568	4	-	-	PUNCT
admet-1513	568	5	a	a	DET
admet-1513	568	6	-	-	PUNCT
admet-1513	568	7	chip	chip	NOUN
admet-1513	568	8	microfluidic	microfluidic	ADJ
admet-1513	568	9	model	model	NOUN
admet-1513	568	10	for	for	ADP
admet-1513	568	11	efficient	efficient	ADJ
admet-1513	568	12	in	in	ADP
admet-1513	568	13	vitro	vitro	X
admet-1513	568	14	screening	screen	VERB
admet-1513	568	15	of	of	ADP
admet-1513	568	16	oral	oral	ADJ
admet-1513	568	17	chemotherapeutic	chemotherapeutic	ADJ
admet-1513	568	18	uptake	uptake	NOUN
admet-1513	568	19	.	.	PUNCT
admet-1513	569	1	acs	acs	PROPN
admet-1513	569	2	biomater	biomater	NOUN
admet-1513	569	3	.	.	PUNCT
admet-1513	570	1	sci	sci	PROPN
admet-1513	570	2	.	.	PUNCT
admet-1513	571	1	eng	eng	PROPN
admet-1513	571	2	.	.	PROPN
admet-1513	571	3	3	3	NUM
admet-1513	571	4	(	(	PUNCT
admet-1513	571	5	2017	2017	NUM
admet-1513	571	6	)	)	PUNCT
admet-1513	571	7	951	951	NUM
admet-1513	571	8	-	-	SYM
admet-1513	571	9	959	959	NUM
admet-1513	571	10	.	.	PUNCT
admet-1513	572	1	https://doi.org/10.1021/acsbiomaterials.7b00023	https://doi.org/10.1021/acsbiomaterials.7b00023	NOUN
admet-1513	572	2	.	.	PUNCT
admet-1513	573	1	[	[	X
admet-1513	573	2	16	16	NUM
admet-1513	573	3	]	]	X
admet-1513	573	4	s.	s.	PROPN
admet-1513	573	5	tavelin	tavelin	PROPN
admet-1513	573	6	,	,	PUNCT
admet-1513	573	7	j.	j.	PROPN
admet-1513	573	8	taipalensuu	taipalensuu	PROPN
admet-1513	573	9	,	,	PUNCT
admet-1513	573	10	l.	l.	PROPN
admet-1513	573	11	söderberg	söderberg	PROPN
admet-1513	573	12	,	,	PUNCT
admet-1513	573	13	r.	r.	PROPN
admet-1513	573	14	morrison	morrison	PROPN
admet-1513	573	15	,	,	PUNCT
admet-1513	573	16	s.	s.	PROPN
admet-1513	573	17	chong	chong	PROPN
admet-1513	573	18	,	,	PUNCT
admet-1513	573	19	p.	p.	PROPN
admet-1513	573	20	artursson	artursson	PROPN
admet-1513	573	21	.	.	PUNCT
admet-1513	574	1	prediction	prediction	NOUN
admet-1513	574	2	of	of	ADP
admet-1513	574	3	the	the	DET
admet-1513	574	4	oral	oral	ADJ
admet-1513	574	5	absorption	absorption	NOUN
admet-1513	574	6	of	of	ADP
admet-1513	574	7	low	low	ADJ
admet-1513	574	8	-	-	PUNCT
admet-1513	574	9	permeability	permeability	NOUN
admet-1513	574	10	drugs	drug	NOUN
admet-1513	574	11	using	use	VERB
admet-1513	574	12	small	small	ADJ
admet-1513	574	13	intestine	intestine	NOUN
admet-1513	574	14	-	-	PUNCT
admet-1513	574	15	like	like	ADJ
admet-1513	574	16	2/4	2/4	NUM
admet-1513	574	17	/	/	SYM
admet-1513	574	18	a1	a1	NOUN
admet-1513	574	19	cell	cell	NOUN
admet-1513	574	20	monolayers	monolayer	NOUN
admet-1513	574	21	.	.	PUNCT
admet-1513	575	1	pharm	pharm	NOUN
admet-1513	575	2	.	.	PUNCT
admet-1513	576	1	res	re	NOUN
admet-1513	576	2	.	.	PROPN
admet-1513	577	1	20	20	NUM
admet-1513	577	2	(	(	PUNCT
admet-1513	577	3	2003	2003	NUM
admet-1513	577	4	)	)	PUNCT
admet-1513	577	5	397	397	NUM
admet-1513	577	6	-	-	SYM
admet-1513	577	7	405	405	NUM
admet-1513	577	8	.	.	PUNCT
admet-1513	578	1	https://doi.org/10.1023/a:1022699920043	https://doi.org/10.1023/a:1022699920043	NOUN
admet-1513	578	2	.	.	PUNCT
admet-1513	579	1	[	[	X
admet-1513	579	2	17	17	NUM
admet-1513	579	3	]	]	X
admet-1513	579	4	s.	s.	PROPN
admet-1513	579	5	fowler	fowler	PROPN
admet-1513	579	6	,	,	PUNCT
admet-1513	579	7	w.l.k	w.l.k	PROPN
admet-1513	579	8	.	.	PUNCT
admet-1513	580	1	chen	chen	PROPN
admet-1513	580	2	,	,	PUNCT
admet-1513	580	3	d.b	d.b	PROPN
admet-1513	580	4	.	.	PROPN
admet-1513	580	5	duignan	duignan	PROPN
admet-1513	580	6	,	,	PUNCT
admet-1513	580	7	a.	a.	PROPN
admet-1513	580	8	gupta	gupta	PROPN
admet-1513	580	9	,	,	PUNCT
admet-1513	580	10	n.	n.	PROPN
admet-1513	580	11	hariparsad	hariparsad	PROPN
admet-1513	580	12	,	,	PUNCT
admet-1513	580	13	j.r	j.r	PROPN
admet-1513	580	14	.	.	PROPN
admet-1513	580	15	kenny	kenny	PROPN
admet-1513	580	16	,	,	PUNCT
admet-1513	580	17	w.g	w.g	PROPN
admet-1513	580	18	.	.	PROPN
admet-1513	580	19	lai	lai	PROPN
admet-1513	580	20	,	,	PUNCT
admet-1513	580	21	j.	j.	PROPN
admet-1513	580	22	liras	liras	PROPN
admet-1513	580	23	,	,	PUNCT
admet-1513	580	24	j.a	j.a	PROPN
admet-1513	580	25	.	.	PROPN
admet-1513	580	26	phillips	phillips	PROPN
admet-1513	580	27	,	,	PUNCT
admet-1513	580	28	j.	j.	PROPN
admet-1513	580	29	gan	gan	PROPN
admet-1513	580	30	.	.	PUNCT
admet-1513	581	1	microphysiological	microphysiological	ADJ
admet-1513	581	2	systems	system	NOUN
admet-1513	581	3	for	for	ADP
admet-1513	581	4	adme	adme	NOUN
admet-1513	581	5	-	-	PUNCT
admet-1513	581	6	related	relate	VERB
admet-1513	581	7	applications	application	NOUN
admet-1513	581	8	:	:	PUNCT
admet-1513	581	9	current	current	ADJ
admet-1513	581	10	status	status	NOUN
admet-1513	581	11	and	and	CCONJ
admet-1513	581	12	recommendations	recommendation	NOUN
admet-1513	581	13	for	for	ADP
admet-1513	581	14	system	system	NOUN
admet-1513	581	15	development	development	NOUN
admet-1513	581	16	and	and	CCONJ
admet-1513	581	17	characterization	characterization	NOUN
admet-1513	581	18	.	.	PUNCT
admet-1513	582	1	lab	lab	NOUN
admet-1513	582	2	chip	chip	NOUN
admet-1513	582	3	20	20	NUM
admet-1513	582	4	(	(	PUNCT
admet-1513	582	5	2020	2020	NUM
admet-1513	582	6	)	)	PUNCT
admet-1513	582	7	446	446	NUM
admet-1513	582	8	-	-	SYM
admet-1513	582	9	467	467	NUM
admet-1513	582	10	.	.	PUNCT
admet-1513	583	1	https://doi.org/10.1039/c9lc00857h	https://doi.org/10.1039/c9lc00857h	PROPN
admet-1513	583	2	.	.	PUNCT
admet-1513	584	1	[	[	X
admet-1513	584	2	18	18	NUM
admet-1513	584	3	]	]	X
admet-1513	584	4	j.m	j.m	PROPN
admet-1513	584	5	.	.	PROPN
admet-1513	584	6	reis	reis	PROPN
admet-1513	584	7	,	,	PUNCT
admet-1513	584	8	b.	b.	PROPN
admet-1513	584	9	sinkó	sinkó	PROPN
admet-1513	584	10	,	,	PUNCT
admet-1513	584	11	c.h	c.h	PROPN
admet-1513	584	12	.	.	PROPN
admet-1513	584	13	serra	serra	PROPN
admet-1513	584	14	.	.	PUNCT
admet-1513	584	15	parallel	parallel	ADJ
admet-1513	584	16	artificial	artificial	ADJ
admet-1513	584	17	membrane	membrane	NOUN
admet-1513	584	18	permeability	permeability	NOUN
admet-1513	584	19	assay	assay	NOUN
admet-1513	584	20	(	(	PUNCT
admet-1513	584	21	pampa	pampa	PROPN
admet-1513	584	22	)	)	PUNCT
admet-1513	584	23	is	be	AUX
admet-1513	584	24	it	it	PRON
admet-1513	584	25	better	well	ADJ
admet-1513	584	26	than	than	ADP
admet-1513	584	27	caco-2	caco-2	NUM
admet-1513	584	28	for	for	ADP
admet-1513	584	29	human	human	ADJ
admet-1513	584	30	passive	passive	ADJ
admet-1513	584	31	permeability	permeability	NOUN
admet-1513	584	32	prediction	prediction	NOUN
admet-1513	584	33	.	.	PUNCT
admet-1513	585	1	mini	mini	ADJ
admet-1513	585	2	rev	rev	PROPN
admet-1513	585	3	.	.	PROPN
admet-1513	585	4	med	med	PROPN
admet-1513	585	5	.	.	PROPN
admet-1513	585	6	chem	chem	PROPN
admet-1513	585	7	.	.	PUNCT
admet-1513	586	1	10	10	NUM
admet-1513	586	2	(	(	PUNCT
admet-1513	586	3	2010	2010	NUM
admet-1513	586	4	)	)	PUNCT
admet-1513	586	5	1071	1071	NUM
admet-1513	586	6	-	-	SYM
admet-1513	586	7	1076	1076	NUM
admet-1513	586	8	.	.	PUNCT
admet-1513	587	1	https://doi.org/10.2174/1389557511009011071	https://doi.org/10.2174/1389557511009011071	VERB
admet-1513	587	2	.	.	PUNCT
admet-1513	588	1	[	[	X
admet-1513	588	2	19	19	NUM
admet-1513	588	3	]	]	SYM
admet-1513	588	4	s.p	s.p	PROPN
admet-1513	588	5	.	.	PROPN
admet-1513	588	6	gantzsch	gantzsch	PROPN
admet-1513	588	7	,	,	PUNCT
admet-1513	588	8	b.	b.	PROPN
admet-1513	588	9	kann	kann	PROPN
admet-1513	588	10	,	,	PUNCT
admet-1513	588	11	m.	m.	NOUN
admet-1513	588	12	ofer	ofer	PROPN
admet-1513	588	13	-	-	PUNCT
admet-1513	588	14	glaessgen	glaessgen	NOUN
admet-1513	588	15	,	,	PUNCT
admet-1513	588	16	p.	p.	NOUN
admet-1513	588	17	loos	loos	PROPN
admet-1513	588	18	,	,	PUNCT
admet-1513	588	19	h.	h.	PROPN
admet-1513	588	20	berchtold	berchtold	PROPN
admet-1513	588	21	,	,	PUNCT
admet-1513	588	22	s.	s.	PROPN
admet-1513	588	23	balbach	balbach	PROPN
admet-1513	588	24	,	,	PUNCT
admet-1513	588	25	t.	t.	NOUN
admet-1513	588	26	eichinger	eichinger	NOUN
admet-1513	588	27	,	,	PUNCT
admet-1513	588	28	c.m	c.m	PROPN
admet-1513	588	29	.	.	PROPN
admet-1513	588	30	lehr	lehr	PROPN
admet-1513	588	31	,	,	PUNCT
admet-1513	588	32	u.f	u.f	PROPN
admet-1513	588	33	.	.	PROPN
admet-1513	588	34	schaefer	schaefer	PROPN
admet-1513	588	35	,	,	PUNCT
admet-1513	588	36	m.	m.	NOUN
admet-1513	588	37	windbergs	windberg	NOUN
admet-1513	588	38	.	.	PUNCT
admet-1513	589	1	characterization	characterization	NOUN
admet-1513	589	2	and	and	CCONJ
admet-1513	589	3	evaluation	evaluation	NOUN
admet-1513	589	4	of	of	ADP
admet-1513	589	5	a	a	DET
admet-1513	589	6	modified	modify	VERB
admet-1513	589	7	pvpa	pvpa	NOUN
admet-1513	589	8	barrier	barrier	NOUN
admet-1513	589	9	in	in	ADP
admet-1513	589	10	comparison	comparison	NOUN
admet-1513	589	11	to	to	ADP
admet-1513	589	12	caco-2	caco-2	NUM
admet-1513	589	13	cell	cell	NOUN
admet-1513	589	14	monolayers	monolayer	NOUN
admet-1513	589	15	for	for	ADP
admet-1513	589	16	combined	combine	VERB
admet-1513	589	17	dissolution	dissolution	NOUN
admet-1513	589	18	and	and	CCONJ
admet-1513	589	19	permeation	permeation	NOUN
admet-1513	589	20	testing	testing	NOUN
admet-1513	589	21	.	.	PUNCT
admet-1513	590	1	j.	j.	PROPN
admet-1513	590	2	control	control	PROPN
admet-1513	590	3	.	.	PUNCT
admet-1513	591	1	release	release	VERB
admet-1513	591	2	175	175	NUM
admet-1513	591	3	(	(	PUNCT
admet-1513	591	4	2014	2014	NUM
admet-1513	591	5	)	)	PUNCT
admet-1513	591	6	79	79	NUM
admet-1513	591	7	-	-	SYM
admet-1513	591	8	86	86	NUM
admet-1513	591	9	.	.	PUNCT
admet-1513	592	1	https://doi.org/10.1016/j.jconrel.2013.12.009	https://doi.org/10.1016/j.jconrel.2013.12.009	X
admet-1513	592	2	.	.	PUNCT
admet-1513	593	1	[	[	X
admet-1513	593	2	20	20	NUM
admet-1513	593	3	]	]	X
admet-1513	593	4	g.e	g.e	PROPN
admet-1513	593	5	.	.	PROPN
admet-1513	593	6	flaten	flaten	PROPN
admet-1513	593	7	,	,	PUNCT
admet-1513	593	8	z.	z.	PROPN
admet-1513	593	9	palac	palac	PROPN
admet-1513	593	10	,	,	PUNCT
admet-1513	593	11	a.	a.	NOUN
admet-1513	593	12	engesland	engesland	NOUN
admet-1513	593	13	,	,	PUNCT
admet-1513	593	14	j.	j.	PROPN
admet-1513	593	15	filipović	filipović	PROPN
admet-1513	593	16	-	-	PUNCT
admet-1513	593	17	grčić	grčić	PROPN
admet-1513	593	18	,	,	PUNCT
admet-1513	593	19	ž	ž	PROPN
admet-1513	593	20	.	.	PROPN
admet-1513	593	21	vanić	vanić	ADJ
admet-1513	593	22	,	,	PUNCT
admet-1513	593	23	n.	n.	ADJ
admet-1513	593	24	škalko	škalko	PROPN
admet-1513	593	25	-	-	PUNCT
admet-1513	593	26	basnet	basnet	NOUN
admet-1513	593	27	.	.	PUNCT
admet-1513	594	1	in	in	ADP
admet-1513	594	2	vitro	vitro	X
admet-1513	594	3	skin	skin	NOUN
admet-1513	594	4	models	model	NOUN
admet-1513	594	5	as	as	ADP
admet-1513	594	6	a	a	DET
admet-1513	594	7	tool	tool	NOUN
admet-1513	594	8	in	in	ADP
admet-1513	594	9	optimization	optimization	NOUN
admet-1513	594	10	of	of	ADP
admet-1513	594	11	drug	drug	NOUN
admet-1513	594	12	formulation	formulation	NOUN
admet-1513	594	13	.	.	PUNCT
admet-1513	595	1	eur	eur	PROPN
admet-1513	595	2	.	.	PUNCT
admet-1513	596	1	j.	j.	PROPN
admet-1513	596	2	pharm	pharm	PROPN
admet-1513	596	3	.	.	PUNCT
admet-1513	597	1	sci	sci	PROPN
admet-1513	597	2	.	.	PROPN
admet-1513	598	1	75	75	NUM
admet-1513	598	2	(	(	PUNCT
admet-1513	598	3	2015	2015	NUM
admet-1513	598	4	)	)	PUNCT
admet-1513	598	5	10	10	NUM
admet-1513	598	6	-	-	SYM
admet-1513	598	7	24	24	NUM
admet-1513	598	8	.	.	PUNCT
admet-1513	599	1	https://doi.org/10.1016/j.ejps.2015.02.018	https://doi.org/10.1016/j.ejps.2015.02.018	NOUN
admet-1513	599	2	.	.	PUNCT
admet-1513	600	1	[	[	X
admet-1513	600	2	21	21	NUM
admet-1513	600	3	]	]	X
admet-1513	600	4	j.	j.	PROPN
admet-1513	600	5	mensch	mensch	PROPN
admet-1513	600	6	,	,	PUNCT
admet-1513	600	7	a.	a.	PROPN
admet-1513	600	8	melis	melis	PROPN
admet-1513	600	9	,	,	PUNCT
admet-1513	600	10	c.	c.	PROPN
admet-1513	600	11	mackie	mackie	PROPN
admet-1513	600	12	,	,	PUNCT
admet-1513	600	13	g.	g.	PROPN
admet-1513	600	14	verreck	verreck	PROPN
admet-1513	600	15	,	,	PUNCT
admet-1513	600	16	m.e	m.e	PROPN
admet-1513	600	17	.	.	PROPN
admet-1513	600	18	brewster	brewster	PROPN
admet-1513	600	19	,	,	PUNCT
admet-1513	600	20	p.	p.	NOUN
admet-1513	600	21	augustijns	augustijns	NOUN
admet-1513	600	22	.	.	PUNCT
admet-1513	601	1	evaluation	evaluation	NOUN
admet-1513	601	2	of	of	ADP
admet-1513	601	3	various	various	ADJ
admet-1513	601	4	pampa	pampa	NOUN
admet-1513	601	5	models	model	NOUN
admet-1513	601	6	to	to	PART
admet-1513	601	7	identify	identify	VERB
admet-1513	601	8	the	the	DET
admet-1513	601	9	most	most	ADV
admet-1513	601	10	discriminating	discriminating	ADJ
admet-1513	601	11	method	method	NOUN
admet-1513	601	12	for	for	ADP
admet-1513	601	13	the	the	DET
admet-1513	601	14	prediction	prediction	NOUN
admet-1513	601	15	of	of	ADP
admet-1513	601	16	bbb	bbb	PROPN
admet-1513	601	17	permeability	permeability	NOUN
admet-1513	601	18	.	.	PUNCT
admet-1513	602	1	eur	eur	PROPN
admet-1513	602	2	.	.	PUNCT
admet-1513	603	1	j.	j.	PROPN
admet-1513	603	2	pharm	pharm	PROPN
admet-1513	603	3	.	.	PUNCT
admet-1513	604	1	biopharm	biopharm	NOUN
admet-1513	604	2	.	.	PUNCT
admet-1513	605	1	74	74	NUM
admet-1513	605	2	(	(	PUNCT
admet-1513	605	3	2010	2010	NUM
admet-1513	605	4	)	)	PUNCT
admet-1513	605	5	495	495	NUM
admet-1513	605	6	-	-	SYM
admet-1513	605	7	502	502	NUM
admet-1513	605	8	.	.	PUNCT
admet-1513	606	1	https://doi.org/10.1016/j.ejpb.2010.01.003	https://doi.org/10.1016/j.ejpb.2010.01.003	NUM
admet-1513	606	2	.	.	PUNCT
admet-1513	607	1	[	[	X
admet-1513	607	2	22	22	NUM
admet-1513	607	3	]	]	X
admet-1513	607	4	e.	e.	PROPN
admet-1513	607	5	naderkhani	naderkhani	PROPN
admet-1513	607	6	,	,	PUNCT
admet-1513	607	7	j.	j.	PROPN
admet-1513	607	8	isaksson	isaksson	PROPN
admet-1513	607	9	,	,	PUNCT
admet-1513	607	10	a.	a.	PROPN
admet-1513	607	11	ryzhakov	ryzhakov	PROPN
admet-1513	607	12	,	,	PUNCT
admet-1513	607	13	g.e	g.e	PROPN
admet-1513	607	14	.	.	PROPN
admet-1513	607	15	flaten	flaten	PROPN
admet-1513	607	16	.	.	PUNCT
admet-1513	608	1	development	development	NOUN
admet-1513	608	2	of	of	ADP
admet-1513	608	3	a	a	DET
admet-1513	608	4	biomimetic	biomimetic	ADJ
admet-1513	608	5	phospholipid	phospholipid	NOUN
admet-1513	608	6	vesicle	vesicle	NOUN
admet-1513	608	7	-	-	PUNCT
admet-1513	608	8	based	base	VERB
admet-1513	608	9	permeation	permeation	NOUN
admet-1513	608	10	assay	assay	VERB
admet-1513	608	11	for	for	ADP
admet-1513	608	12	the	the	DET
admet-1513	608	13	estimation	estimation	NOUN
admet-1513	608	14	of	of	ADP
admet-1513	608	15	intestinal	intestinal	ADJ
admet-1513	608	16	drug	drug	NOUN
admet-1513	608	17	permeability	permeability	NOUN
admet-1513	608	18	.	.	PUNCT
admet-1513	609	1	j.	j.	PROPN
admet-1513	609	2	pharm	pharm	PROPN
admet-1513	609	3	.	.	PUNCT
admet-1513	610	1	sci	sci	PROPN
admet-1513	610	2	.	.	PROPN
admet-1513	610	3	103	103	NUM
admet-1513	610	4	(	(	PUNCT
admet-1513	610	5	2014	2014	NUM
admet-1513	610	6	)	)	PUNCT
admet-1513	610	7	1882	1882	NUM
admet-1513	610	8	-	-	SYM
admet-1513	610	9	1890	1890	NUM
admet-1513	610	10	.	.	PUNCT
admet-1513	611	1	https://doi.org/10.1002/jps.23954	https://doi.org/10.1002/jps.23954	PROPN
admet-1513	611	2	.	.	PUNCT
admet-1513	612	1	[	[	X
admet-1513	612	2	23	23	NUM
admet-1513	612	3	]	]	X
admet-1513	612	4	b.	b.	PROPN
admet-1513	612	5	sarmento	sarmento	PROPN
admet-1513	612	6	,	,	PUNCT
admet-1513	612	7	f.	f.	PROPN
admet-1513	612	8	andrade	andrade	PROPN
admet-1513	612	9	,	,	PUNCT
admet-1513	612	10	s.b	s.b	PROPN
admet-1513	612	11	.	.	PROPN
admet-1513	612	12	da	da	PROPN
admet-1513	612	13	silva	silva	PROPN
admet-1513	612	14	,	,	PUNCT
admet-1513	612	15	f.	f.	PROPN
admet-1513	612	16	rodrigues	rodrigues	PROPN
admet-1513	612	17	,	,	PUNCT
admet-1513	612	18	j.	j.	PROPN
admet-1513	612	19	das	das	PROPN
admet-1513	612	20	neves	neves	PROPN
admet-1513	612	21	,	,	PUNCT
admet-1513	612	22	d.	d.	PROPN
admet-1513	612	23	ferreira	ferreira	PROPN
admet-1513	612	24	.	.	PUNCT
admet-1513	613	1	cell	cell	NOUN
admet-1513	613	2	-	-	PUNCT
admet-1513	613	3	based	base	VERB
admet-1513	613	4	in	in	ADP
admet-1513	613	5	vitro	vitro	X
admet-1513	613	6	models	model	NOUN
admet-1513	613	7	for	for	ADP
admet-1513	613	8	predicting	predict	VERB
admet-1513	613	9	drug	drug	NOUN
admet-1513	613	10	permeability	permeability	NOUN
admet-1513	613	11	.	.	PUNCT
admet-1513	614	1	expert	expert	NOUN
admet-1513	614	2	opin	opin	NOUN
admet-1513	614	3	.	.	PUNCT
admet-1513	615	1	drug	drug	NOUN
admet-1513	615	2	metab	metab	NOUN
admet-1513	615	3	.	.	PUNCT
admet-1513	616	1	toxicol	toxicol	PROPN
admet-1513	616	2	.	.	PROPN
admet-1513	616	3	8	8	NUM
admet-1513	616	4	(	(	PUNCT
admet-1513	616	5	2012	2012	NUM
admet-1513	616	6	)	)	PUNCT
admet-1513	616	7	607	607	NUM
admet-1513	616	8	-	-	SYM
admet-1513	616	9	621	621	NUM
admet-1513	616	10	.	.	PUNCT
admet-1513	617	1	https://doi.org/10.1517/17425255.2012.673586	https://doi.org/10.1517/17425255.2012.673586	PROPN
admet-1513	617	2	.	.	PUNCT
admet-1513	618	1	[	[	X
admet-1513	618	2	24	24	NUM
admet-1513	618	3	]	]	X
admet-1513	618	4	i.d	i.d	PROPN
admet-1513	618	5	.	.	PROPN
admet-1513	618	6	angelis	angelis	PROPN
admet-1513	618	7	,	,	PUNCT
admet-1513	618	8	l.	l.	PROPN
admet-1513	618	9	turco	turco	PROPN
admet-1513	618	10	.	.	PUNCT
admet-1513	619	1	caco-2	caco-2	NUM
admet-1513	619	2	cells	cell	NOUN
admet-1513	619	3	as	as	ADP
admet-1513	619	4	a	a	DET
admet-1513	619	5	model	model	NOUN
admet-1513	619	6	for	for	ADP
admet-1513	619	7	intestinal	intestinal	ADJ
admet-1513	619	8	absorption	absorption	NOUN
admet-1513	619	9	.	.	PUNCT
admet-1513	620	1	curr	curr	AUX
admet-1513	620	2	.	.	PUNCT
admet-1513	620	3	protoc	protoc	PROPN
admet-1513	620	4	.	.	PUNCT
admet-1513	621	1	toxicol	toxicol	PROPN
admet-1513	621	2	.	.	PUNCT
admet-1513	622	1	chapter	chapter	NOUN
admet-1513	622	2	20	20	NUM
admet-1513	622	3	(	(	PUNCT
admet-1513	622	4	2011	2011	NUM
admet-1513	622	5	)	)	PUNCT
admet-1513	622	6	unit20.6	unit20.6	PROPN
admet-1513	622	7	.	.	PUNCT
admet-1513	622	8	https://doi.org/10.1002/0471140856.tx2006s47	https://doi.org/10.1002/0471140856.tx2006s47	PROPN
admet-1513	622	9	.	.	PUNCT
admet-1513	623	1	[	[	X
admet-1513	623	2	25	25	NUM
admet-1513	623	3	]	]	PUNCT
admet-1513	623	4	m.	m.	PROPN
admet-1513	623	5	hu	hu	PROPN
admet-1513	623	6	,	,	PUNCT
admet-1513	623	7	j.	j.	PROPN
admet-1513	623	8	ling	ling	PROPN
admet-1513	623	9	,	,	PUNCT
admet-1513	623	10	h.	h.	PROPN
admet-1513	623	11	lin	lin	PROPN
admet-1513	623	12	,	,	PUNCT
admet-1513	623	13	j.	j.	PROPN
admet-1513	623	14	chen	chen	PROPN
admet-1513	623	15	.	.	PUNCT
admet-1513	624	1	use	use	NOUN
admet-1513	624	2	of	of	ADP
admet-1513	624	3	caco-2	caco-2	NUM
admet-1513	624	4	cell	cell	NOUN
admet-1513	624	5	monolayers	monolayer	NOUN
admet-1513	624	6	to	to	PART
admet-1513	624	7	study	study	VERB
admet-1513	624	8	drug	drug	NOUN
admet-1513	624	9	absorption	absorption	NOUN
admet-1513	624	10	and	and	CCONJ
admet-1513	624	11	metabolism	metabolism	NOUN
admet-1513	624	12	.	.	PUNCT
admet-1513	625	1	in	in	ADP
admet-1513	625	2	optimization	optimization	NOUN
admet-1513	625	3	in	in	ADP
admet-1513	625	4	drug	drug	NOUN
admet-1513	625	5	discovery	discovery	NOUN
admet-1513	625	6	,	,	PUNCT
admet-1513	625	7	humana	humana	PROPN
admet-1513	625	8	press	press	PROPN
admet-1513	625	9	,	,	PUNCT
admet-1513	625	10	2004	2004	NUM
admet-1513	625	11	,	,	PUNCT
admet-1513	625	12	p.	p.	NOUN
admet-1513	625	13	19	19	NUM
admet-1513	625	14	-	-	SYM
admet-1513	625	15	35	35	NUM
admet-1513	625	16	.	.	PUNCT
admet-1513	626	1	[	[	X
admet-1513	626	2	26	26	NUM
admet-1513	626	3	]	]	X
admet-1513	626	4	d.c	d.c	PROPN
admet-1513	626	5	.	.	PUNCT
admet-1513	626	6	kim	kim	PROPN
admet-1513	626	7	,	,	PUNCT
admet-1513	626	8	p.s	p.s	PROPN
admet-1513	626	9	.	.	PROPN
admet-1513	626	10	burton	burton	PROPN
admet-1513	626	11	,	,	PUNCT
admet-1513	626	12	r.t	r.t	PROPN
admet-1513	626	13	.	.	PROPN
admet-1513	626	14	borchardt	borchardt	PROPN
admet-1513	626	15	.	.	PUNCT
admet-1513	627	1	a	a	DET
admet-1513	627	2	correlation	correlation	NOUN
admet-1513	627	3	between	between	ADP
admet-1513	627	4	the	the	DET
admet-1513	627	5	permeability	permeability	NOUN
admet-1513	627	6	characteristics	characteristic	NOUN
admet-1513	627	7	of	of	ADP
admet-1513	627	8	a	a	DET
admet-1513	627	9	series	series	NOUN
admet-1513	627	10	of	of	ADP
admet-1513	627	11	peptides	peptide	NOUN
admet-1513	627	12	using	use	VERB
admet-1513	627	13	an	an	DET
admet-1513	627	14	in	in	ADV
admet-1513	627	15	vitro	vitro	X
admet-1513	627	16	cell	cell	NOUN
admet-1513	627	17	culture	culture	NOUN
admet-1513	627	18	model	model	NOUN
admet-1513	627	19	(	(	PUNCT
admet-1513	627	20	caco-2	caco-2	NUM
admet-1513	627	21	)	)	PUNCT
admet-1513	627	22	and	and	CCONJ
admet-1513	627	23	those	those	PRON
admet-1513	627	24	using	use	VERB
admet-1513	627	25	an	an	DET
admet-1513	627	26	in	in	ADP
admet-1513	627	27	situ	situ	ADJ
admet-1513	627	28	perfused	perfuse	VERB
admet-1513	627	29	rat	rat	NOUN
admet-1513	627	30	ileum	ileum	NOUN
admet-1513	627	31	model	model	NOUN
admet-1513	627	32	of	of	ADP
admet-1513	627	33	the	the	DET
admet-1513	627	34	intestinal	intestinal	ADJ
admet-1513	627	35	mucosa	mucosa	NOUN
admet-1513	627	36	.	.	PUNCT
admet-1513	628	1	pharm	pharm	NOUN
admet-1513	628	2	.	.	PUNCT
admet-1513	629	1	res	re	NOUN
admet-1513	629	2	.	.	PROPN
admet-1513	630	1	10	10	NUM
admet-1513	630	2	(	(	PUNCT
admet-1513	630	3	1993	1993	NUM
admet-1513	630	4	)	)	PUNCT
admet-1513	630	5	1710	1710	NUM
admet-1513	630	6	-	-	SYM
admet-1513	630	7	1714	1714	NUM
admet-1513	630	8	.	.	PUNCT
admet-1513	631	1	https://doi.org/10.1023/a:1018961828510	https://doi.org/10.1023/a:1018961828510	PROPN
admet-1513	631	2	.	.	PUNCT
admet-1513	632	1	[	[	X
admet-1513	632	2	27	27	NUM
admet-1513	632	3	]	]	PUNCT
admet-1513	632	4	p.	p.	PROPN
admet-1513	632	5	artursson	artursson	PROPN
admet-1513	632	6	,	,	PUNCT
admet-1513	632	7	k.	k.	PROPN
admet-1513	632	8	palm	palm	PROPN
admet-1513	632	9	,	,	PUNCT
admet-1513	632	10	k.	k.	PROPN
admet-1513	632	11	luthman	luthman	PROPN
admet-1513	632	12	.	.	PUNCT
admet-1513	633	1	caco-2	caco-2	NUM
admet-1513	633	2	monolayers	monolayer	NOUN
admet-1513	633	3	in	in	ADP
admet-1513	633	4	experimental	experimental	ADJ
admet-1513	633	5	and	and	CCONJ
admet-1513	633	6	theoretical	theoretical	ADJ
admet-1513	633	7	predictions	prediction	NOUN
admet-1513	633	8	of	of	ADP
admet-1513	633	9	drug	drug	NOUN
admet-1513	633	10	transport	transport	NOUN
admet-1513	633	11	.	.	PUNCT
admet-1513	634	1	adv	adv	PROPN
admet-1513	634	2	.	.	PUNCT
admet-1513	634	3	drug	drug	PROPN
admet-1513	634	4	deliv	deliv	PROPN
admet-1513	634	5	.	.	PUNCT
admet-1513	635	1	rev	rev	PROPN
admet-1513	635	2	.	.	PROPN
admet-1513	635	3	46	46	NUM
admet-1513	635	4	(	(	PUNCT
admet-1513	635	5	2001	2001	NUM
admet-1513	635	6	)	)	PUNCT
admet-1513	635	7	27	27	NUM
admet-1513	635	8	-	-	SYM
admet-1513	635	9	43	43	NUM
admet-1513	635	10	.	.	PUNCT
admet-1513	636	1	https://doi.org/10.1016/s0169-409x(00)00128-9	https://doi.org/10.1016/s0169-409x(00)00128-9	NOUN
admet-1513	636	2	.	.	PUNCT
admet-1513	637	1	[	[	X
admet-1513	637	2	28	28	NUM
admet-1513	637	3	]	]	X
admet-1513	637	4	j.	j.	PROPN
admet-1513	637	5	hunter	hunter	PROPN
admet-1513	637	6	,	,	PUNCT
admet-1513	637	7	m.a	m.a	PROPN
admet-1513	637	8	.	.	PROPN
admet-1513	637	9	jepson	jepson	PROPN
admet-1513	637	10	,	,	PUNCT
admet-1513	637	11	t.	t.	PROPN
admet-1513	637	12	tsuruo	tsuruo	PROPN
admet-1513	637	13	,	,	PUNCT
admet-1513	637	14	n.l	n.l	PROPN
admet-1513	637	15	.	.	PROPN
admet-1513	637	16	simmons	simmons	PROPN
admet-1513	637	17	,	,	PUNCT
admet-1513	637	18	b.h	b.h	PROPN
admet-1513	637	19	.	.	PROPN
admet-1513	637	20	hirst	hirst	PROPN
admet-1513	637	21	.	.	PUNCT
admet-1513	638	1	functional	functional	ADJ
admet-1513	638	2	expression	expression	NOUN
admet-1513	638	3	of	of	ADP
admet-1513	638	4	p	p	NOUN
admet-1513	638	5	-	-	PUNCT
admet-1513	638	6	glycoprotein	glycoprotein	NOUN
admet-1513	638	7	in	in	ADP
admet-1513	638	8	apical	apical	ADJ
admet-1513	638	9	membranes	membrane	NOUN
admet-1513	638	10	of	of	ADP
admet-1513	638	11	human	human	ADJ
admet-1513	638	12	intestinal	intestinal	ADJ
admet-1513	638	13	caco-2	caco-2	NUM
admet-1513	638	14	cells	cell	NOUN
admet-1513	638	15	.	.	PUNCT
admet-1513	639	1	kinetics	kinetic	NOUN
admet-1513	639	2	of	of	ADP
admet-1513	639	3	vinblastine	vinblastine	NOUN
admet-1513	639	4	secretion	secretion	NOUN
admet-1513	639	5	and	and	CCONJ
admet-1513	639	6	interaction	interaction	NOUN
admet-1513	639	7	with	with	ADP
admet-1513	639	8	modulators	modulator	NOUN
admet-1513	639	9	.	.	PUNCT
admet-1513	640	1	j.	j.	PROPN
admet-1513	640	2	biol	biol	PROPN
admet-1513	640	3	.	.	PUNCT
admet-1513	641	1	chem	chem	NOUN
admet-1513	641	2	.	.	PUNCT
admet-1513	642	1	268	268	NUM
admet-1513	642	2	(	(	PUNCT
admet-1513	642	3	1993	1993	NUM
admet-1513	642	4	)	)	PUNCT
admet-1513	642	5	14991	14991	NUM
admet-1513	642	6	-	-	SYM
admet-1513	642	7	14997	14997	NUM
admet-1513	642	8	.	.	PUNCT
admet-1513	643	1	https://doi.org/10.1016/s0021-9258(18)82429-2	https://doi.org/10.1016/s0021-9258(18)82429-2	NOUN
admet-1513	643	2	.	.	PUNCT
admet-1513	644	1	https://doi.org/10.1021/acsbiomaterials.7b00023	https://doi.org/10.1021/acsbiomaterials.7b00023	PROPN
admet-1513	644	2	https://doi.org/10.1023/a:1022699920043	https://doi.org/10.1023/a:1022699920043	NOUN
admet-1513	644	3	https://doi.org/10.1039/c9lc00857h	https://doi.org/10.1039/c9lc00857h	PROPN
admet-1513	644	4	https://doi.org/10.1016/j.jconrel.2013.12.009	https://doi.org/10.1016/j.jconrel.2013.12.009	X
admet-1513	644	5	https://doi.org/10.1016/j.ejps.2015.02.018	https://doi.org/10.1016/j.ejps.2015.02.018	PROPN
admet-1513	644	6	https://doi.org/10.1016/j.ejpb.2010.01.003	https://doi.org/10.1016/j.ejpb.2010.01.003	PROPN
admet-1513	644	7	https://doi.org/10.1002/jps.23954	https://doi.org/10.1002/jps.23954	PROPN
admet-1513	644	8	https://doi.org/10.1517/17425255.2012.673586	https://doi.org/10.1517/17425255.2012.673586	PROPN
admet-1513	644	9	https://doi.org/10.1002/0471140856.tx2006s47	https://doi.org/10.1002/0471140856.tx2006s47	PROPN
admet-1513	644	10	https://doi.org/10.1023/a:1018961828510	https://doi.org/10.1023/a:1018961828510	PROPN
admet-1513	644	11	https://doi.org/10.1023/a:1018961828510	https://doi.org/10.1023/a:1018961828510	VERB
admet-1513	644	12	https://doi.org/10.1016/s0169-409x(00)00128-9	https://doi.org/10.1016/s0169-409x(00)00128-9	PROPN
admet-1513	645	1	https://doi.org/10.1016/s0169-409x(00)00128-9	https://doi.org/10.1016/s0169-409x(00)00128-9	PROPN
admet-1513	645	2	https://doi.org/10.1016/s0021-9258(18)82429-2	https://doi.org/10.1016/s0021-9258(18)82429-2	PROPN
admet-1513	645	3	https://doi.org/10.1016/s0021-9258(18)82429-2	https://doi.org/10.1016/s0021-9258(18)82429-2	PROPN
admet-1513	645	4	admet	admet	PROPN
admet-1513	645	5	&	&	CCONJ
admet-1513	645	6	dmpk	dmpk	PROPN
admet-1513	645	7	11(1	11(1	NUM
admet-1513	645	8	)	)	PUNCT
admet-1513	645	9	(	(	PUNCT
admet-1513	645	10	2023	2023	NUM
admet-1513	645	11	)	)	PUNCT
admet-1513	645	12	1	1	NUM
admet-1513	645	13	-	-	SYM
admet-1513	645	14	32	32	NUM
admet-1513	645	15	2d	2d	NOUN
admet-1513	645	16	and	and	CCONJ
admet-1513	645	17	3d	3d	NOUN
admet-1513	645	18	adme	adme	PROPN
admet-1513	645	19	-	-	PUNCT
admet-1513	645	20	tox	tox	NOUN
admet-1513	645	21	cell	cell	NOUN
admet-1513	645	22	culture	culture	NOUN
admet-1513	645	23	screening	screen	VERB
admet-1513	645	24	:	:	PUNCT
admet-1513	645	25	a	a	DET
admet-1513	645	26	review	review	NOUN
admet-1513	645	27	doi	doi	NOUN
admet-1513	645	28	:	:	PUNCT
admet-1513	645	29	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	645	30	19	19	NUM
admet-1513	646	1	[	[	SYM
admet-1513	646	2	29	29	NUM
admet-1513	646	3	]	]	X
admet-1513	646	4	n.	n.	PROPN
admet-1513	646	5	maubon	maubon	PROPN
admet-1513	646	6	,	,	PUNCT
admet-1513	646	7	m.	m.	NOUN
admet-1513	646	8	le	le	PROPN
admet-1513	646	9	vee	vee	PROPN
admet-1513	646	10	,	,	PUNCT
admet-1513	646	11	l.	l.	PROPN
admet-1513	646	12	fossati	fossati	PROPN
admet-1513	646	13	,	,	PUNCT
admet-1513	646	14	m.	m.	NOUN
admet-1513	646	15	audry	audry	PROPN
admet-1513	646	16	,	,	PUNCT
admet-1513	646	17	e.	e.	PROPN
admet-1513	646	18	le	le	PROPN
admet-1513	646	19	ferrec	ferrec	PROPN
admet-1513	646	20	,	,	PUNCT
admet-1513	646	21	s.	s.	PROPN
admet-1513	646	22	bolze	bolze	PROPN
admet-1513	646	23	,	,	PUNCT
admet-1513	646	24	o.	o.	PROPN
admet-1513	646	25	fardel	fardel	PROPN
admet-1513	646	26	.	.	PUNCT
admet-1513	647	1	analysis	analysis	NOUN
admet-1513	647	2	of	of	ADP
admet-1513	647	3	drug	drug	NOUN
admet-1513	647	4	transporter	transporter	NOUN
admet-1513	647	5	expression	expression	NOUN
admet-1513	647	6	in	in	ADP
admet-1513	647	7	human	human	ADJ
admet-1513	647	8	intestinal	intestinal	ADJ
admet-1513	647	9	caco-2	caco-2	NUM
admet-1513	647	10	cells	cell	NOUN
admet-1513	647	11	by	by	ADP
admet-1513	647	12	real	real	ADJ
admet-1513	647	13	-	-	PUNCT
admet-1513	647	14	time	time	NOUN
admet-1513	647	15	pcr	pcr	NOUN
admet-1513	647	16	.	.	PUNCT
admet-1513	648	1	fundam	fundam	PROPN
admet-1513	648	2	.	.	PUNCT
admet-1513	649	1	clin	clin	PROPN
admet-1513	649	2	.	.	PUNCT
admet-1513	650	1	pharmacol	pharmacol	PROPN
admet-1513	650	2	.	.	PROPN
admet-1513	651	1	21	21	NUM
admet-1513	651	2	(	(	PUNCT
admet-1513	651	3	2007	2007	NUM
admet-1513	651	4	)	)	PUNCT
admet-1513	651	5	659	659	NUM
admet-1513	651	6	-	-	SYM
admet-1513	651	7	663	663	NUM
admet-1513	651	8	.	.	PUNCT
admet-1513	652	1	https://doi.org/10.1111/j.1472-8206.2007.00550.x	https://doi.org/10.1111/j.1472-8206.2007.00550.x	ADJ
admet-1513	652	2	.	.	PUNCT
admet-1513	653	1	[	[	X
admet-1513	653	2	30	30	NUM
admet-1513	653	3	]	]	X
admet-1513	653	4	m.h	m.h	PROPN
admet-1513	653	5	.	.	PROPN
admet-1513	653	6	macedo	macedo	PROPN
admet-1513	653	7	,	,	PUNCT
admet-1513	653	8	f.	f.	PROPN
admet-1513	653	9	araújo	araújo	PROPN
admet-1513	653	10	,	,	PUNCT
admet-1513	653	11	e.	e.	PROPN
admet-1513	653	12	martínez	martínez	PROPN
admet-1513	653	13	,	,	PUNCT
admet-1513	653	14	c.	c.	PROPN
admet-1513	653	15	barrias	barrias	PROPN
admet-1513	653	16	,	,	PUNCT
admet-1513	653	17	b.	b.	PROPN
admet-1513	653	18	sarmento	sarmento	PROPN
admet-1513	653	19	.	.	PUNCT
admet-1513	654	1	ipsc	ipsc	NOUN
admet-1513	654	2	-	-	PUNCT
admet-1513	654	3	derived	derive	VERB
admet-1513	654	4	enterocyte	enterocyte	NOUN
admet-1513	654	5	-	-	PUNCT
admet-1513	654	6	like	like	ADJ
admet-1513	654	7	cells	cell	NOUN
admet-1513	654	8	for	for	ADP
admet-1513	654	9	drug	drug	NOUN
admet-1513	654	10	absorption	absorption	NOUN
admet-1513	654	11	and	and	CCONJ
admet-1513	654	12	metabolism	metabolism	NOUN
admet-1513	654	13	studies	study	NOUN
admet-1513	654	14	.	.	PUNCT
admet-1513	655	1	trends	trend	NOUN
admet-1513	655	2	mol	mol	PROPN
admet-1513	655	3	.	.	PROPN
admet-1513	655	4	med	med	PROPN
admet-1513	655	5	.	.	PROPN
admet-1513	656	1	24	24	NUM
admet-1513	656	2	(	(	PUNCT
admet-1513	656	3	2018	2018	NUM
admet-1513	656	4	)	)	PUNCT
admet-1513	656	5	696	696	NUM
admet-1513	656	6	-	-	SYM
admet-1513	656	7	708	708	NUM
admet-1513	656	8	.	.	PUNCT
admet-1513	657	1	https://doi.org/10.1016/j.molmed.2018.06.001	https://doi.org/10.1016/j.molmed.2018.06.001	VERB
admet-1513	657	2	.	.	PUNCT
admet-1513	658	1	[	[	X
admet-1513	658	2	31	31	NUM
admet-1513	658	3	]	]	X
admet-1513	658	4	d.	d.	PROPN
admet-1513	658	5	sun	sun	PROPN
admet-1513	658	6	,	,	PUNCT
admet-1513	658	7	h.	h.	PROPN
admet-1513	658	8	lennernas	lennernas	PROPN
admet-1513	658	9	,	,	PUNCT
admet-1513	658	10	l.s	l.s	PROPN
admet-1513	658	11	.	.	PROPN
admet-1513	658	12	welage	welage	PROPN
admet-1513	658	13	,	,	PUNCT
admet-1513	658	14	j.l	j.l	PROPN
admet-1513	658	15	.	.	PROPN
admet-1513	658	16	barnett	barnett	PROPN
admet-1513	658	17	,	,	PUNCT
admet-1513	658	18	c.p	c.p	PROPN
admet-1513	658	19	.	.	PROPN
admet-1513	658	20	landowski	landowski	PROPN
admet-1513	658	21	,	,	PUNCT
admet-1513	658	22	d.	d.	PROPN
admet-1513	658	23	foster	foster	PROPN
admet-1513	658	24	,	,	PUNCT
admet-1513	658	25	d.	d.	PROPN
admet-1513	658	26	fleisher	fleisher	PROPN
admet-1513	658	27	,	,	PUNCT
admet-1513	658	28	k.d	k.d	PROPN
admet-1513	658	29	.	.	PROPN
admet-1513	658	30	lee	lee	PROPN
admet-1513	658	31	,	,	PUNCT
admet-1513	658	32	g.l	g.l	PROPN
admet-1513	658	33	.	.	PROPN
admet-1513	658	34	amidon	amidon	PROPN
admet-1513	658	35	.	.	PUNCT
admet-1513	659	1	comparison	comparison	NOUN
admet-1513	659	2	of	of	ADP
admet-1513	659	3	human	human	ADJ
admet-1513	659	4	duodenum	duodenum	NOUN
admet-1513	659	5	and	and	CCONJ
admet-1513	659	6	caco-2	caco-2	NUM
admet-1513	659	7	gene	gene	NOUN
admet-1513	659	8	expression	expression	NOUN
admet-1513	659	9	profiles	profile	NOUN
admet-1513	659	10	for	for	ADP
admet-1513	659	11	12,000	12,000	NUM
admet-1513	659	12	gene	gene	NOUN
admet-1513	659	13	sequences	sequence	NOUN
admet-1513	659	14	tags	tag	NOUN
admet-1513	659	15	and	and	CCONJ
admet-1513	659	16	correlation	correlation	NOUN
admet-1513	659	17	with	with	ADP
admet-1513	659	18	permeability	permeability	NOUN
admet-1513	659	19	of	of	ADP
admet-1513	659	20	26	26	NUM
admet-1513	659	21	drugs	drug	NOUN
admet-1513	659	22	.	.	PUNCT
admet-1513	660	1	pharm	pharm	NOUN
admet-1513	660	2	.	.	PUNCT
admet-1513	661	1	res	re	NOUN
admet-1513	661	2	.	.	PROPN
admet-1513	662	1	19	19	NUM
admet-1513	662	2	(	(	PUNCT
admet-1513	662	3	2002	2002	NUM
admet-1513	662	4	)	)	PUNCT
admet-1513	662	5	1400	1400	NUM
admet-1513	662	6	-	-	SYM
admet-1513	662	7	1416	1416	NUM
admet-1513	662	8	.	.	PUNCT
admet-1513	663	1	https://doi.org/10.1023/a:1020483911355	https://doi.org/10.1023/a:1020483911355	ADJ
admet-1513	663	2	.	.	PUNCT
admet-1513	664	1	[	[	X
admet-1513	664	2	32	32	NUM
admet-1513	664	3	]	]	PUNCT
admet-1513	664	4	p.	p.	PROPN
admet-1513	664	5	artursson	artursson	PROPN
admet-1513	664	6	.	.	PUNCT
admet-1513	665	1	cell	cell	NOUN
admet-1513	665	2	cultures	culture	NOUN
admet-1513	665	3	as	as	ADP
admet-1513	665	4	models	model	NOUN
admet-1513	665	5	for	for	ADP
admet-1513	665	6	drug	drug	NOUN
admet-1513	665	7	absorption	absorption	NOUN
admet-1513	665	8	across	across	ADP
admet-1513	665	9	the	the	DET
admet-1513	665	10	intestinal	intestinal	ADJ
admet-1513	665	11	mucosa	mucosa	NOUN
admet-1513	665	12	.	.	PUNCT
admet-1513	666	1	crit	crit	PROPN
admet-1513	666	2	.	.	PUNCT
admet-1513	667	1	rev	rev	PROPN
admet-1513	667	2	.	.	PROPN
admet-1513	668	1	ther	ther	PROPN
admet-1513	668	2	.	.	PUNCT
admet-1513	669	1	drug	drug	NOUN
admet-1513	669	2	carrier	carrier	NOUN
admet-1513	669	3	syst	syst	PROPN
admet-1513	669	4	.	.	PROPN
admet-1513	669	5	8	8	NUM
admet-1513	669	6	(	(	PUNCT
admet-1513	669	7	1991	1991	NUM
admet-1513	669	8	)	)	PUNCT
admet-1513	669	9	305	305	NUM
admet-1513	669	10	-	-	SYM
admet-1513	669	11	330	330	NUM
admet-1513	669	12	.	.	PUNCT
admet-1513	670	1	[	[	X
admet-1513	670	2	33	33	NUM
admet-1513	670	3	]	]	PUNCT
admet-1513	670	4	b.	b.	PROPN
admet-1513	670	5	srinivasan	srinivasan	PROPN
admet-1513	670	6	,	,	PUNCT
admet-1513	670	7	a.r	a.r	PROPN
admet-1513	670	8	.	.	PROPN
admet-1513	670	9	kolli	kolli	PROPN
admet-1513	670	10	,	,	PUNCT
admet-1513	670	11	m.b	m.b	PROPN
admet-1513	670	12	.	.	PROPN
admet-1513	670	13	esch	esch	PROPN
admet-1513	670	14	,	,	PUNCT
admet-1513	670	15	h.e	h.e	PROPN
admet-1513	670	16	.	.	PROPN
admet-1513	670	17	abaci	abaci	PROPN
admet-1513	670	18	,	,	PUNCT
admet-1513	670	19	m.l	m.l	PROPN
admet-1513	670	20	.	.	PROPN
admet-1513	670	21	shuler	shuler	PROPN
admet-1513	670	22	,	,	PUNCT
admet-1513	670	23	j.j	j.j	PROPN
admet-1513	670	24	.	.	PROPN
admet-1513	670	25	hickman	hickman	PROPN
admet-1513	670	26	.	.	PUNCT
admet-1513	671	1	teer	teer	PROPN
admet-1513	671	2	measurement	measurement	NOUN
admet-1513	671	3	techniques	technique	NOUN
admet-1513	671	4	for	for	ADP
admet-1513	671	5	in	in	ADP
admet-1513	671	6	vitro	vitro	X
admet-1513	671	7	barrier	barrier	NOUN
admet-1513	671	8	model	model	NOUN
admet-1513	671	9	systems	system	NOUN
admet-1513	671	10	.	.	PUNCT
admet-1513	672	1	j.	j.	PROPN
admet-1513	672	2	lab	lab	PROPN
admet-1513	672	3	.	.	PUNCT
admet-1513	673	1	autom	autom	PROPN
admet-1513	673	2	.	.	PUNCT
admet-1513	674	1	20	20	NUM
admet-1513	674	2	(	(	PUNCT
admet-1513	674	3	2015	2015	NUM
admet-1513	674	4	)	)	PUNCT
admet-1513	674	5	107	107	NUM
admet-1513	674	6	-	-	SYM
admet-1513	674	7	126	126	NUM
admet-1513	674	8	.	.	PUNCT
admet-1513	675	1	https://doi.org/10.1177/2211068214561025	https://doi.org/10.1177/2211068214561025	NOUN
admet-1513	675	2	.	.	PUNCT
admet-1513	676	1	[	[	X
admet-1513	676	2	34	34	NUM
admet-1513	676	3	]	]	X
admet-1513	676	4	e.l	e.l	PROPN
admet-1513	676	5	.	.	PROPN
admet-1513	676	6	ferrec	ferrec	PROPN
admet-1513	676	7	,	,	PUNCT
admet-1513	676	8	o.	o.	PROPN
admet-1513	676	9	fardel	fardel	PROPN
admet-1513	676	10	.	.	PUNCT
admet-1513	677	1	applications	application	NOUN
admet-1513	677	2	using	use	VERB
admet-1513	677	3	c	c	NOUN
admet-1513	677	4	aco‐2	aco‐2	PROPN
admet-1513	677	5	and	and	CCONJ
admet-1513	677	6	tc	tc	NOUN
admet-1513	677	7	7	7	NUM
admet-1513	677	8	cells	cell	NOUN
admet-1513	677	9	for	for	ADP
admet-1513	677	10	drug	drug	NOUN
admet-1513	677	11	metabolism	metabolism	NOUN
admet-1513	677	12	studies	study	NOUN
admet-1513	677	13	.	.	PUNCT
admet-1513	678	1	encyclopedia	encyclopedia	NOUN
admet-1513	678	2	of	of	ADP
admet-1513	678	3	drug	drug	NOUN
admet-1513	678	4	metabolism	metabolism	NOUN
admet-1513	678	5	and	and	CCONJ
admet-1513	678	6	interactions	interaction	NOUN
admet-1513	678	7	,	,	PUNCT
admet-1513	678	8	john	john	PROPN
admet-1513	678	9	wiley	wiley	PROPN
admet-1513	678	10	&	&	CCONJ
admet-1513	678	11	sons	son	NOUN
admet-1513	678	12	,	,	PUNCT
admet-1513	678	13	2012	2012	NUM
admet-1513	678	14	,	,	PUNCT
admet-1513	678	15	p.	p.	NOUN
admet-1513	678	16	1	1	NUM
admet-1513	678	17	-	-	SYM
admet-1513	678	18	16	16	NUM
admet-1513	678	19	.	.	PUNCT
admet-1513	679	1	[	[	X
admet-1513	679	2	35	35	NUM
admet-1513	679	3	]	]	PUNCT
admet-1513	679	4	x.	x.	NOUN
admet-1513	679	5	liu	liu	PROPN
admet-1513	679	6	,	,	PUNCT
admet-1513	679	7	v.h	v.h	PROPN
admet-1513	679	8	.	.	PROPN
admet-1513	679	9	tam	tam	PROPN
admet-1513	679	10	,	,	PUNCT
admet-1513	679	11	m.	m.	PROPN
admet-1513	679	12	hu	hu	PROPN
admet-1513	679	13	.	.	PROPN
admet-1513	679	14	disposition	disposition	NOUN
admet-1513	679	15	of	of	ADP
admet-1513	679	16	flavonoids	flavonoid	NOUN
admet-1513	679	17	via	via	ADP
admet-1513	679	18	enteric	enteric	ADJ
admet-1513	679	19	recycling	recycling	NOUN
admet-1513	679	20	:	:	PUNCT
admet-1513	679	21	determination	determination	NOUN
admet-1513	679	22	of	of	ADP
admet-1513	679	23	the	the	DET
admet-1513	679	24	udpglucuronosyltransferase	udpglucuronosyltransferase	PROPN
admet-1513	679	25	isoforms	isoform	NOUN
admet-1513	679	26	responsible	responsible	ADJ
admet-1513	679	27	for	for	ADP
admet-1513	679	28	the	the	DET
admet-1513	679	29	metabolism	metabolism	NOUN
admet-1513	679	30	of	of	ADP
admet-1513	679	31	flavonoids	flavonoid	NOUN
admet-1513	679	32	in	in	ADP
admet-1513	679	33	intact	intact	ADJ
admet-1513	679	34	caco-2	caco-2	NUM
admet-1513	679	35	tc7	tc7	NOUN
admet-1513	679	36	cells	cell	NOUN
admet-1513	679	37	using	use	VERB
admet-1513	679	38	sirna	sirna	PROPN
admet-1513	679	39	.	.	PUNCT
admet-1513	680	1	mol	mol	PROPN
admet-1513	680	2	.	.	PUNCT
admet-1513	680	3	pharm	pharm	PROPN
admet-1513	680	4	.	.	PUNCT
admet-1513	681	1	4	4	NUM
admet-1513	681	2	(	(	PUNCT
admet-1513	681	3	2007	2007	NUM
admet-1513	681	4	)	)	PUNCT
admet-1513	681	5	873	873	NUM
admet-1513	681	6	-	-	SYM
admet-1513	681	7	882	882	NUM
admet-1513	681	8	.	.	PUNCT
admet-1513	682	1	https://doi.org/10.1021/mp0601190	https://doi.org/10.1021/mp0601190	PROPN
admet-1513	682	2	.	.	PUNCT
admet-1513	683	1	[	[	X
admet-1513	683	2	36	36	NUM
admet-1513	683	3	]	]	X
admet-1513	683	4	l.	l.	PROPN
admet-1513	683	5	turco	turco	PROPN
admet-1513	683	6	,	,	PUNCT
admet-1513	683	7	t.	t.	PROPN
admet-1513	683	8	catone	catone	PROPN
admet-1513	683	9	,	,	PUNCT
admet-1513	683	10	f.	f.	PROPN
admet-1513	683	11	caloni	caloni	PROPN
admet-1513	683	12	,	,	PUNCT
admet-1513	683	13	e.	e.	PROPN
admet-1513	683	14	di	di	PROPN
admet-1513	683	15	consiglio	consiglio	PROPN
admet-1513	683	16	,	,	PUNCT
admet-1513	683	17	e.	e.	PROPN
admet-1513	683	18	testai	testai	PROPN
admet-1513	683	19	,	,	PUNCT
admet-1513	683	20	a.	a.	PROPN
admet-1513	683	21	stammati	stammati	PROPN
admet-1513	683	22	.	.	PUNCT
admet-1513	683	23	caco-2	caco-2	NUM
admet-1513	683	24	/	/	SYM
admet-1513	683	25	tc7	tc7	NOUN
admet-1513	683	26	cell	cell	NOUN
admet-1513	683	27	line	line	NOUN
admet-1513	683	28	characterization	characterization	NOUN
admet-1513	683	29	for	for	ADP
admet-1513	683	30	intestinal	intestinal	ADJ
admet-1513	683	31	absorption	absorption	NOUN
admet-1513	683	32	:	:	PUNCT
admet-1513	683	33	how	how	SCONJ
admet-1513	683	34	reliable	reliable	ADJ
admet-1513	683	35	is	be	AUX
admet-1513	683	36	this	this	PRON
admet-1513	683	37	in	in	ADP
admet-1513	683	38	vitro	vitro	X
admet-1513	683	39	model	model	NOUN
admet-1513	683	40	for	for	ADP
admet-1513	683	41	the	the	DET
admet-1513	683	42	prediction	prediction	NOUN
admet-1513	683	43	of	of	ADP
admet-1513	683	44	the	the	DET
admet-1513	683	45	oral	oral	ADJ
admet-1513	683	46	dose	dose	NOUN
admet-1513	683	47	fraction	fraction	NOUN
admet-1513	683	48	absorbed	absorb	VERB
admet-1513	683	49	in	in	ADP
admet-1513	683	50	human	human	NOUN
admet-1513	683	51	.	.	PUNCT
admet-1513	684	1	toxicol	toxicol	PROPN
admet-1513	684	2	.	.	PUNCT
admet-1513	685	1	in	in	ADP
admet-1513	685	2	vitro	vitro	X
admet-1513	685	3	25	25	NUM
admet-1513	685	4	(	(	PUNCT
admet-1513	685	5	2011	2011	NUM
admet-1513	685	6	)	)	PUNCT
admet-1513	685	7	13	13	NUM
admet-1513	685	8	-	-	SYM
admet-1513	685	9	20	20	NUM
admet-1513	685	10	.	.	PUNCT
admet-1513	686	1	https://doi.org/10.1016/j.tiv.2010.08.009	https://doi.org/10.1016/j.tiv.2010.08.009	PROPN
admet-1513	686	2	.	.	PUNCT
admet-1513	687	1	[	[	X
admet-1513	687	2	37	37	NUM
admet-1513	687	3	]	]	X
admet-1513	687	4	h.	h.	PROPN
admet-1513	687	5	lennernäs	lennernäs	PROPN
admet-1513	687	6	,	,	PUNCT
admet-1513	687	7	k.	k.	PROPN
admet-1513	687	8	palm	palm	PROPN
admet-1513	687	9	,	,	PUNCT
admet-1513	687	10	u.	u.	PROPN
admet-1513	687	11	fagerholm	fagerholm	PROPN
admet-1513	687	12	,	,	PUNCT
admet-1513	687	13	p.	p.	PROPN
admet-1513	687	14	artursson	artursson	PROPN
admet-1513	687	15	.	.	PUNCT
admet-1513	688	1	comparison	comparison	NOUN
admet-1513	688	2	between	between	ADP
admet-1513	688	3	active	active	ADJ
admet-1513	688	4	and	and	CCONJ
admet-1513	688	5	passive	passive	ADJ
admet-1513	688	6	drug	drug	NOUN
admet-1513	688	7	transport	transport	NOUN
admet-1513	688	8	in	in	ADP
admet-1513	688	9	human	human	ADJ
admet-1513	688	10	intestinal	intestinal	ADJ
admet-1513	688	11	epithelial	epithelial	ADJ
admet-1513	688	12	(	(	PUNCT
admet-1513	688	13	caco-2	caco-2	NOUN
admet-1513	688	14	)	)	PUNCT
admet-1513	688	15	cells	cell	NOUN
admet-1513	688	16	in	in	ADP
admet-1513	688	17	vitro	vitro	X
admet-1513	688	18	and	and	CCONJ
admet-1513	688	19	human	human	NOUN
admet-1513	688	20	jejunum	jejunum	NOUN
admet-1513	688	21	in	in	ADP
admet-1513	688	22	vivo	vivo	NOUN
admet-1513	688	23	.	.	PUNCT
admet-1513	689	1	int	int	NOUN
admet-1513	689	2	.	.	PUNCT
admet-1513	690	1	j.	j.	PROPN
admet-1513	690	2	pharm	pharm	PROPN
admet-1513	690	3	.	.	PUNCT
admet-1513	691	1	127(1	127(1	NUM
admet-1513	691	2	)	)	PUNCT
admet-1513	691	3	(	(	PUNCT
admet-1513	691	4	1995	1995	NUM
admet-1513	691	5	)	)	PUNCT
admet-1513	691	6	103	103	NUM
admet-1513	691	7	-	-	SYM
admet-1513	691	8	107	107	NUM
admet-1513	691	9	.	.	PUNCT
admet-1513	692	1	https://doi.org/10.1016/0378-5173(95)04204-0	https://doi.org/10.1016/0378-5173(95)04204-0	NOUN
admet-1513	692	2	.	.	PUNCT
admet-1513	693	1	[	[	X
admet-1513	693	2	38	38	NUM
admet-1513	693	3	]	]	X
admet-1513	693	4	m.j	m.j	PROPN
admet-1513	693	5	.	.	PROPN
admet-1513	693	6	cho	cho	PROPN
admet-1513	693	7	,	,	PUNCT
admet-1513	693	8	d.p	d.p	PROPN
admet-1513	693	9	.	.	PROPN
admet-1513	693	10	thompson	thompson	PROPN
admet-1513	693	11	,	,	PUNCT
admet-1513	693	12	c.t	c.t	PROPN
admet-1513	693	13	.	.	PROPN
admet-1513	693	14	cramer	cramer	PROPN
admet-1513	693	15	,	,	PUNCT
admet-1513	693	16	t.j	t.j	PROPN
admet-1513	693	17	.	.	PROPN
admet-1513	693	18	vidmar	vidmar	PROPN
admet-1513	693	19	,	,	PUNCT
admet-1513	693	20	j.f	j.f	PROPN
admet-1513	693	21	.	.	PROPN
admet-1513	693	22	scieszka	scieszka	PROPN
admet-1513	693	23	.	.	PUNCT
admet-1513	694	1	the	the	DET
admet-1513	694	2	madin	madin	VERB
admet-1513	694	3	darby	darby	PROPN
admet-1513	694	4	canine	canine	PROPN
admet-1513	694	5	kidney	kidney	NOUN
admet-1513	694	6	(	(	PUNCT
admet-1513	694	7	mdck	mdck	ADJ
admet-1513	694	8	)	)	PUNCT
admet-1513	694	9	epithelial	epithelial	ADJ
admet-1513	694	10	cell	cell	NOUN
admet-1513	694	11	monolayer	monolayer	NOUN
admet-1513	694	12	as	as	ADP
admet-1513	694	13	a	a	DET
admet-1513	694	14	model	model	ADJ
admet-1513	694	15	cellular	cellular	ADJ
admet-1513	694	16	transport	transport	NOUN
admet-1513	694	17	barrier	barrier	NOUN
admet-1513	694	18	.	.	PUNCT
admet-1513	695	1	pharm	pharm	NOUN
admet-1513	695	2	.	.	PUNCT
admet-1513	696	1	res	re	NOUN
admet-1513	696	2	.	.	PROPN
admet-1513	697	1	6	6	NUM
admet-1513	697	2	(	(	PUNCT
admet-1513	697	3	1989	1989	NUM
admet-1513	697	4	)	)	PUNCT
admet-1513	697	5	71	71	NUM
admet-1513	697	6	-	-	SYM
admet-1513	697	7	77	77	NUM
admet-1513	697	8	.	.	PUNCT
admet-1513	698	1	https://doi.org/10.1023/a:1015807904558	https://doi.org/10.1023/a:1015807904558	NOUN
admet-1513	698	2	.	.	PUNCT
admet-1513	699	1	[	[	X
admet-1513	699	2	39	39	NUM
admet-1513	699	3	]	]	PUNCT
admet-1513	699	4	f.	f.	PROPN
admet-1513	699	5	antunes	antunes	PROPN
admet-1513	699	6	,	,	PUNCT
admet-1513	699	7	f.	f.	PROPN
admet-1513	699	8	andrade	andrade	PROPN
admet-1513	699	9	,	,	PUNCT
admet-1513	699	10	d.	d.	PROPN
admet-1513	699	11	ferreira	ferreira	PROPN
admet-1513	699	12	,	,	PUNCT
admet-1513	699	13	h.m	h.m	PROPN
admet-1513	699	14	.	.	PROPN
admet-1513	699	15	nielsen	nielsen	PROPN
admet-1513	699	16	,	,	PUNCT
admet-1513	699	17	b.	b.	PROPN
admet-1513	699	18	sarmento	sarmento	PROPN
admet-1513	699	19	.	.	PUNCT
admet-1513	699	20	models	model	NOUN
admet-1513	699	21	to	to	PART
admet-1513	699	22	predict	predict	VERB
admet-1513	699	23	intestinal	intestinal	ADJ
admet-1513	699	24	absorption	absorption	NOUN
admet-1513	699	25	of	of	ADP
admet-1513	699	26	therapeutic	therapeutic	ADJ
admet-1513	699	27	peptides	peptide	NOUN
admet-1513	699	28	and	and	CCONJ
admet-1513	699	29	proteins	protein	NOUN
admet-1513	699	30	.	.	PUNCT
admet-1513	700	1	curr	curr	PROPN
admet-1513	700	2	.	.	PUNCT
admet-1513	700	3	drug	drug	PROPN
admet-1513	700	4	metab	metab	NOUN
admet-1513	700	5	.	.	PUNCT
admet-1513	701	1	14	14	NUM
admet-1513	701	2	(	(	PUNCT
admet-1513	701	3	2013	2013	NUM
admet-1513	701	4	)	)	PUNCT
admet-1513	701	5	4	4	NUM
admet-1513	701	6	-	-	SYM
admet-1513	701	7	20	20	NUM
admet-1513	701	8	.	.	PUNCT
admet-1513	702	1	https://doi.org/10.2174/138920013804545160	https://doi.org/10.2174/138920013804545160	NOUN
admet-1513	702	2	.	.	PUNCT
admet-1513	703	1	[	[	X
admet-1513	703	2	40	40	NUM
admet-1513	703	3	]	]	PUNCT
admet-1513	703	4	f.	f.	PROPN
admet-1513	703	5	tang	tang	PROPN
admet-1513	703	6	,	,	PUNCT
admet-1513	703	7	k.	k.	PROPN
admet-1513	703	8	horie	horie	PROPN
admet-1513	703	9	,	,	PUNCT
admet-1513	703	10	r.t	r.t	PROPN
admet-1513	703	11	.	.	PROPN
admet-1513	703	12	borchardt	borchardt	PROPN
admet-1513	703	13	.	.	PUNCT
admet-1513	704	1	are	be	AUX
admet-1513	704	2	mdck	mdck	PROPN
admet-1513	704	3	cells	cell	NOUN
admet-1513	704	4	transfected	transfecte	VERB
admet-1513	704	5	with	with	ADP
admet-1513	704	6	the	the	DET
admet-1513	704	7	human	human	ADJ
admet-1513	704	8	mrp2	mrp2	PROPN
admet-1513	704	9	gene	gene	VERB
admet-1513	704	10	a	a	DET
admet-1513	704	11	good	good	ADJ
admet-1513	704	12	model	model	NOUN
admet-1513	704	13	of	of	ADP
admet-1513	704	14	the	the	DET
admet-1513	704	15	human	human	ADJ
admet-1513	704	16	intestinal	intestinal	ADJ
admet-1513	704	17	mucosa	mucosa	NOUN
admet-1513	704	18	.	.	PUNCT
admet-1513	705	1	pharm	pharm	NOUN
admet-1513	705	2	.	.	PUNCT
admet-1513	706	1	res	re	NOUN
admet-1513	706	2	.	.	PROPN
admet-1513	707	1	19	19	NUM
admet-1513	707	2	(	(	PUNCT
admet-1513	707	3	2002	2002	NUM
admet-1513	707	4	)	)	PUNCT
admet-1513	707	5	773	773	NUM
admet-1513	707	6	-	-	SYM
admet-1513	707	7	779	779	NUM
admet-1513	707	8	.	.	PUNCT
admet-1513	708	1	https://doi.org/10.1023/a:1016192413308	https://doi.org/10.1023/a:1016192413308	NOUN
admet-1513	708	2	.	.	PUNCT
admet-1513	709	1	[	[	X
admet-1513	709	2	41	41	NUM
admet-1513	709	3	]	]	X
admet-1513	709	4	d.a	d.a	PROPN
admet-1513	709	5	.	.	PROPN
admet-1513	709	6	volpe	volpe	PROPN
admet-1513	709	7	.	.	PUNCT
admet-1513	709	8	drug	drug	NOUN
admet-1513	709	9	-	-	PUNCT
admet-1513	709	10	permeability	permeability	NOUN
admet-1513	709	11	and	and	CCONJ
admet-1513	709	12	transporter	transporter	NOUN
admet-1513	709	13	assays	assay	NOUN
admet-1513	709	14	in	in	ADP
admet-1513	709	15	caco-2	caco-2	NUM
admet-1513	709	16	and	and	CCONJ
admet-1513	709	17	mdck	mdck	PROPN
admet-1513	709	18	cell	cell	NOUN
admet-1513	709	19	lines	line	NOUN
admet-1513	709	20	.	.	PUNCT
admet-1513	710	1	future	future	ADJ
admet-1513	710	2	med	med	PROPN
admet-1513	710	3	.	.	PROPN
admet-1513	710	4	chem	chem	PROPN
admet-1513	710	5	.	.	PUNCT
admet-1513	711	1	3	3	NUM
admet-1513	711	2	(	(	PUNCT
admet-1513	711	3	2011	2011	NUM
admet-1513	711	4	)	)	PUNCT
admet-1513	711	5	2063	2063	NUM
admet-1513	711	6	-	-	SYM
admet-1513	711	7	2077	2077	NUM
admet-1513	711	8	.	.	PUNCT
admet-1513	712	1	https://doi.org/10.4155/fmc.11.149	https://doi.org/10.4155/fmc.11.149	ADJ
admet-1513	712	2	.	.	PUNCT
admet-1513	713	1	[	[	X
admet-1513	713	2	42	42	NUM
admet-1513	713	3	]	]	X
admet-1513	713	4	d.	d.	PROPN
admet-1513	713	5	martínez	martínez	PROPN
admet-1513	713	6	-	-	PUNCT
admet-1513	713	7	maqueda	maqueda	PROPN
admet-1513	713	8	,	,	PUNCT
admet-1513	713	9	b.	b.	PROPN
admet-1513	713	10	miralles	miralles	PROPN
admet-1513	713	11	,	,	PUNCT
admet-1513	713	12	i.	i.	PROPN
admet-1513	713	13	recio	recio	PROPN
admet-1513	713	14	.	.	PUNCT
admet-1513	714	1	ht29	ht29	ADJ
admet-1513	714	2	cell	cell	NOUN
admet-1513	714	3	line	line	NOUN
admet-1513	714	4	.	.	PUNCT
admet-1513	715	1	in	in	ADP
admet-1513	715	2	:	:	PUNCT
admet-1513	715	3	the	the	DET
admet-1513	715	4	impact	impact	NOUN
admet-1513	715	5	of	of	ADP
admet-1513	715	6	food	food	NOUN
admet-1513	715	7	bioactives	bioactive	VERB
admet-1513	715	8	on	on	ADP
admet-1513	715	9	health	health	NOUN
admet-1513	715	10	:	:	PUNCT
admet-1513	715	11	in	in	ADP
admet-1513	715	12	vitro	vitro	X
admet-1513	715	13	and	and	CCONJ
admet-1513	715	14	ex	ex	PRON
admet-1513	715	15	vivo	vivo	NOUN
admet-1513	715	16	models	model	NOUN
admet-1513	715	17	[	[	X
admet-1513	715	18	internet	internet	NOUN
admet-1513	715	19	]	]	PUNCT
admet-1513	715	20	.	.	PUNCT
admet-1513	716	1	cham	cham	PROPN
admet-1513	716	2	(	(	PUNCT
admet-1513	716	3	ch	ch	NOUN
admet-1513	716	4	):	):	PUNCT
admet-1513	716	5	springer	springer	NOUN
admet-1513	716	6	,	,	PUNCT
admet-1513	716	7	2015	2015	NUM
admet-1513	716	8	,	,	PUNCT
admet-1513	716	9	p.	p.	NOUN
admet-1513	716	10	113	113	NUM
admet-1513	716	11	-	-	SYM
admet-1513	716	12	124	124	NUM
admet-1513	716	13	.	.	PUNCT
admet-1513	717	1	https://doi.org/10.1007/978-3-319-16104-4_11	https://doi.org/10.1007/978-3-319-16104-4_11	PROPN
admet-1513	717	2	.	.	PUNCT
admet-1513	718	1	[	[	X
admet-1513	718	2	43	43	NUM
admet-1513	718	3	]	]	PUNCT
admet-1513	718	4	t.	t.	PROPN
admet-1513	718	5	lesuffleur	lesuffleur	PROPN
admet-1513	718	6	,	,	PUNCT
admet-1513	718	7	a.	a.	NOUN
admet-1513	718	8	barbat	barbat	PROPN
admet-1513	718	9	,	,	PUNCT
admet-1513	718	10	e.	e.	PROPN
admet-1513	718	11	dussaulx	dussaulx	PROPN
admet-1513	718	12	,	,	PUNCT
admet-1513	718	13	a.	a.	NOUN
admet-1513	718	14	zweibaum	zweibaum	NOUN
admet-1513	718	15	.	.	PUNCT
admet-1513	719	1	growth	growth	NOUN
admet-1513	719	2	adaptation	adaptation	NOUN
admet-1513	719	3	to	to	PART
admet-1513	719	4	methotrexate	methotrexate	VERB
admet-1513	719	5	of	of	ADP
admet-1513	719	6	ht-29	ht-29	PUNCT
admet-1513	719	7	human	human	ADJ
admet-1513	719	8	colon	colon	NOUN
admet-1513	719	9	carcinoma	carcinoma	NOUN
admet-1513	719	10	cells	cell	NOUN
admet-1513	719	11	is	be	AUX
admet-1513	719	12	associated	associate	VERB
admet-1513	719	13	with	with	ADP
admet-1513	719	14	their	their	PRON
admet-1513	719	15	ability	ability	NOUN
admet-1513	719	16	to	to	PART
admet-1513	719	17	differentiate	differentiate	VERB
admet-1513	719	18	into	into	ADP
admet-1513	719	19	columnar	columnar	ADJ
admet-1513	719	20	absorptive	absorptive	ADJ
admet-1513	719	21	and	and	CCONJ
admet-1513	719	22	mucus	mucus	NOUN
admet-1513	719	23	-	-	PUNCT
admet-1513	719	24	secreting	secrete	VERB
admet-1513	719	25	cells	cell	NOUN
admet-1513	719	26	.	.	PUNCT
admet-1513	720	1	cancer	cancer	NOUN
admet-1513	720	2	res	re	NOUN
admet-1513	720	3	.	.	PUNCT
admet-1513	721	1	50	50	NUM
admet-1513	721	2	(	(	PUNCT
admet-1513	721	3	1990	1990	NUM
admet-1513	721	4	)	)	PUNCT
admet-1513	721	5	6334	6334	NUM
admet-1513	721	6	-	-	SYM
admet-1513	721	7	6343	6343	NUM
admet-1513	721	8	.	.	PUNCT
admet-1513	722	1	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	722	2	https://doi.org/10.1111/j.1472-8206.2007.00550.x	https://doi.org/10.1111/j.1472-8206.2007.00550.x	PROPN
admet-1513	722	3	https://doi.org/10.1016/j.molmed.2018.06.001	https://doi.org/10.1016/j.molmed.2018.06.001	PROPN
admet-1513	722	4	https://doi.org/10.1016/j.molmed.2018.06.001	https://doi.org/10.1016/j.molmed.2018.06.001	VERB
admet-1513	722	5	https://doi.org/10.1023/a:1020483911355	https://doi.org/10.1023/a:1020483911355	PROPN
admet-1513	722	6	https://doi.org/10.1177/2211068214561025	https://doi.org/10.1177/2211068214561025	X
admet-1513	722	7	https://doi.org/10.1177/2211068214561025	https://doi.org/10.1177/2211068214561025	NOUN
admet-1513	723	1	https://doi.org/10.1021/mp0601190	https://doi.org/10.1021/mp0601190	PROPN
admet-1513	723	2	https://doi.org/10.1016/j.tiv.2010.08.009	https://doi.org/10.1016/j.tiv.2010.08.009	PROPN
admet-1513	723	3	https://doi.org/10.1016/j.tiv.2010.08.009	https://doi.org/10.1016/j.tiv.2010.08.009	PROPN
admet-1513	723	4	https://doi.org/10.1016/0378-5173(95)04204-0	https://doi.org/10.1016/0378-5173(95)04204-0	PROPN
admet-1513	723	5	https://doi.org/10.1023/a:1015807904558	https://doi.org/10.1023/a:1015807904558	VERB
admet-1513	723	6	https://doi.org/10.2174/138920013804545160	https://doi.org/10.2174/138920013804545160	NOUN
admet-1513	723	7	https://doi.org/10.1023/a:1016192413308	https://doi.org/10.1023/a:1016192413308	ADP
admet-1513	723	8	https://doi.org/10.1023/a:1016192413308	https://doi.org/10.1023/a:1016192413308	ADP
admet-1513	723	9	https://doi.org/10.4155/fmc.11.149	https://doi.org/10.4155/fmc.11.149	ADJ
admet-1513	723	10	https://doi.org/10.1007/978-3-319-16104-4_11	https://doi.org/10.1007/978-3-319-16104-4_11	PROPN
admet-1513	723	11	venkatesh	venkatesh	NOUN
admet-1513	723	12	chunduri	chunduri	NOUN
admet-1513	723	13	and	and	CCONJ
admet-1513	723	14	srinivas	srinivas	PROPN
admet-1513	723	15	maddi	maddi	PROPN
admet-1513	723	16	admet	admet	PROPN
admet-1513	723	17	&	&	CCONJ
admet-1513	723	18	dmpk	dmpk	PROPN
admet-1513	723	19	11(1	11(1	NUM
admet-1513	723	20	)	)	PUNCT
admet-1513	723	21	(	(	PUNCT
admet-1513	723	22	2023	2023	NUM
admet-1513	723	23	)	)	PUNCT
admet-1513	723	24	1	1	NUM
admet-1513	723	25	-	-	SYM
admet-1513	723	26	32	32	NUM
admet-1513	723	27	20	20	NUM
admet-1513	723	28	[	[	SYM
admet-1513	723	29	44	44	NUM
admet-1513	723	30	]	]	PUNCT
admet-1513	723	31	r.	r.	PROPN
admet-1513	723	32	dupak	dupak	PROPN
admet-1513	723	33	,	,	PUNCT
admet-1513	723	34	i.	i.	PROPN
admet-1513	723	35	spevakova	spevakova	PROPN
admet-1513	723	36	,	,	PUNCT
admet-1513	723	37	m.	m.	PROPN
admet-1513	723	38	capcarova	capcarova	PROPN
admet-1513	723	39	.	.	PUNCT
admet-1513	724	1	use	use	NOUN
admet-1513	724	2	of	of	ADP
admet-1513	724	3	ht-29	ht-29	PUNCT
admet-1513	724	4	cell	cell	NOUN
admet-1513	724	5	line	line	NOUN
admet-1513	724	6	to	to	PART
admet-1513	724	7	investigate	investigate	VERB
admet-1513	724	8	toxicological	toxicological	ADJ
admet-1513	724	9	effects	effect	NOUN
admet-1513	724	10	of	of	ADP
admet-1513	724	11	mycotoxins	mycotoxin	NOUN
admet-1513	724	12	:	:	PUNCT
admet-1513	724	13	a	a	DET
admet-1513	724	14	mini	mini	ADJ
admet-1513	724	15	review	review	NOUN
admet-1513	724	16	.	.	PUNCT
admet-1513	725	1	scientific	scientific	ADJ
admet-1513	725	2	papers	paper	NOUN
admet-1513	725	3	:	:	PUNCT
admet-1513	725	4	animal	animal	NOUN
admet-1513	725	5	science	science	NOUN
admet-1513	725	6	&	&	CCONJ
admet-1513	725	7	biotechnologies	biotechnology	NOUN
admet-1513	725	8	,	,	PUNCT
admet-1513	725	9	ebsco	ebsco	PROPN
admet-1513	725	10	,	,	PUNCT
admet-1513	725	11	2020	2020	NUM
admet-1513	725	12	,	,	PUNCT
admet-1513	725	13	p.	p.	NOUN
admet-1513	725	14	160163	160163	NUM
admet-1513	725	15	.	.	PUNCT
admet-1513	726	1	[	[	X
admet-1513	726	2	45	45	NUM
admet-1513	726	3	]	]	X
admet-1513	726	4	m.n	m.n	PROPN
admet-1513	726	5	.	.	PROPN
admet-1513	726	6	bavaria	bavaria	PROPN
admet-1513	726	7	,	,	PUNCT
admet-1513	726	8	s.	s.	PROPN
admet-1513	726	9	jin	jin	PROPN
admet-1513	726	10	,	,	PUNCT
admet-1513	726	11	r.m	r.m	PROPN
admet-1513	726	12	.	.	PROPN
admet-1513	726	13	ray	ray	PROPN
admet-1513	726	14	,	,	PUNCT
admet-1513	726	15	l.r	l.r	PROPN
admet-1513	726	16	.	.	PROPN
admet-1513	726	17	johnson	johnson	PROPN
admet-1513	726	18	.	.	PUNCT
admet-1513	727	1	the	the	DET
admet-1513	727	2	mechanism	mechanism	NOUN
admet-1513	727	3	by	by	ADP
admet-1513	727	4	which	which	PRON
admet-1513	727	5	mek	mek	PROPN
admet-1513	727	6	/	/	SYM
admet-1513	727	7	erk	erk	PROPN
admet-1513	727	8	regulates	regulate	VERB
admet-1513	727	9	jnk	jnk	PROPN
admet-1513	727	10	and	and	CCONJ
admet-1513	727	11	p38	p38	NOUN
admet-1513	727	12	activity	activity	NOUN
admet-1513	727	13	in	in	ADP
admet-1513	727	14	polyamine	polyamine	NOUN
admet-1513	727	15	depleted	deplete	VERB
admet-1513	727	16	iec-6	iec-6	SYM
admet-1513	727	17	cells	cell	NOUN
admet-1513	727	18	during	during	ADP
admet-1513	727	19	apoptosis	apoptosis	NOUN
admet-1513	727	20	.	.	PUNCT
admet-1513	728	1	apoptosis	apoptosis	NOUN
admet-1513	728	2	19	19	NUM
admet-1513	728	3	(	(	PUNCT
admet-1513	728	4	2014	2014	NUM
admet-1513	728	5	)	)	PUNCT
admet-1513	728	6	467	467	NUM
admet-1513	728	7	-	-	SYM
admet-1513	728	8	479	479	NUM
admet-1513	728	9	.	.	PUNCT
admet-1513	729	1	https://doi.org/10.1007/s10495-013-0944-1	https://doi.org/10.1007/s10495-013-0944-1	NUM
admet-1513	729	2	.	.	PUNCT
admet-1513	730	1	[	[	X
admet-1513	730	2	46	46	NUM
admet-1513	730	3	]	]	X
admet-1513	730	4	t.y	t.y	PROPN
admet-1513	730	5	.	.	PROPN
admet-1513	730	6	ma	ma	PROPN
admet-1513	730	7	,	,	PUNCT
admet-1513	730	8	d.	d.	PROPN
admet-1513	730	9	hollander	hollander	PROPN
admet-1513	730	10	,	,	PUNCT
admet-1513	730	11	d.	d.	PROPN
admet-1513	730	12	bhalla	bhalla	PROPN
admet-1513	730	13	,	,	PUNCT
admet-1513	730	14	h.	h.	PROPN
admet-1513	730	15	nguyen	nguyen	PROPN
admet-1513	730	16	,	,	PUNCT
admet-1513	730	17	p.	p.	PROPN
admet-1513	730	18	krugliak	krugliak	PROPN
admet-1513	730	19	.	.	PUNCT
admet-1513	731	1	iec-18	iec-18	PROPN
admet-1513	731	2	,	,	PUNCT
admet-1513	731	3	a	a	DET
admet-1513	731	4	nontransformed	nontransformed	ADJ
admet-1513	731	5	small	small	ADJ
admet-1513	731	6	intestinal	intestinal	ADJ
admet-1513	731	7	cell	cell	NOUN
admet-1513	731	8	line	line	NOUN
admet-1513	731	9	for	for	ADP
admet-1513	731	10	studying	study	VERB
admet-1513	731	11	epithelial	epithelial	ADJ
admet-1513	731	12	permeability	permeability	NOUN
admet-1513	731	13	.	.	PUNCT
admet-1513	732	1	j.	j.	PROPN
admet-1513	732	2	lab	lab	PROPN
admet-1513	732	3	.	.	PUNCT
admet-1513	733	1	clin	clin	PROPN
admet-1513	733	2	.	.	PUNCT
admet-1513	734	1	med	med	PROPN
admet-1513	734	2	.	.	PUNCT
admet-1513	735	1	120	120	NUM
admet-1513	735	2	(	(	PUNCT
admet-1513	735	3	1992	1992	NUM
admet-1513	735	4	)	)	PUNCT
admet-1513	735	5	329	329	NUM
admet-1513	735	6	-	-	SYM
admet-1513	735	7	341	341	NUM
admet-1513	735	8	.	.	PUNCT
admet-1513	736	1	[	[	X
admet-1513	736	2	47	47	NUM
admet-1513	736	3	]	]	PUNCT
admet-1513	736	4	z.	z.	PROPN
admet-1513	736	5	liu	liu	PROPN
admet-1513	736	6	,	,	PUNCT
admet-1513	736	7	p.	p.	PROPN
admet-1513	736	8	zhang	zhang	PROPN
admet-1513	736	9	,	,	PUNCT
admet-1513	736	10	y.	y.	PROPN
admet-1513	736	11	zhou	zhou	PROPN
admet-1513	736	12	,	,	PUNCT
admet-1513	736	13	h.	h.	PROPN
admet-1513	736	14	qin	qin	PROPN
admet-1513	736	15	,	,	PUNCT
admet-1513	736	16	t.	t.	PROPN
admet-1513	736	17	shen	shen	PROPN
admet-1513	736	18	.	.	PUNCT
admet-1513	737	1	culture	culture	NOUN
admet-1513	737	2	of	of	ADP
admet-1513	737	3	human	human	ADJ
admet-1513	737	4	intestinal	intestinal	ADJ
admet-1513	737	5	epithelial	epithelial	ADJ
admet-1513	737	6	cell	cell	NOUN
admet-1513	737	7	using	use	VERB
admet-1513	737	8	the	the	DET
admet-1513	737	9	dissociating	dissociate	VERB
admet-1513	737	10	enzyme	enzyme	NOUN
admet-1513	737	11	thermolysin	thermolysin	NOUN
admet-1513	737	12	and	and	CCONJ
admet-1513	737	13	endothelin-3	endothelin-3	PROPN
admet-1513	737	14	.	.	PROPN
admet-1513	737	15	braz	braz	PROPN
admet-1513	737	16	.	.	PUNCT
admet-1513	738	1	j.	j.	PROPN
admet-1513	738	2	med	med	PROPN
admet-1513	738	3	.	.	PUNCT
admet-1513	739	1	biol	biol	PROPN
admet-1513	739	2	.	.	PUNCT
admet-1513	740	1	res	re	NOUN
admet-1513	740	2	.	.	PUNCT
admet-1513	741	1	43	43	NUM
admet-1513	741	2	(	(	PUNCT
admet-1513	741	3	2010	2010	NUM
admet-1513	741	4	)	)	PUNCT
admet-1513	741	5	451	451	NUM
admet-1513	741	6	-	-	SYM
admet-1513	741	7	459	459	NUM
admet-1513	741	8	.	.	PUNCT
admet-1513	742	1	https://doi.org/10.1590/s0100-879x2010007500036	https://doi.org/10.1590/s0100-879x2010007500036	PROPN
admet-1513	742	2	.	.	PUNCT
admet-1513	743	1	[	[	X
admet-1513	743	2	48	48	NUM
admet-1513	743	3	]	]	X
admet-1513	743	4	n.	n.	NOUN
admet-1513	743	5	perreault	perreault	PROPN
admet-1513	743	6	,	,	PUNCT
admet-1513	743	7	j.f	j.f	PROPN
admet-1513	743	8	.	.	PROPN
admet-1513	743	9	beaulieu	beaulieu	NOUN
admet-1513	743	10	.	.	PUNCT
admet-1513	744	1	use	use	NOUN
admet-1513	744	2	of	of	ADP
admet-1513	744	3	the	the	DET
admet-1513	744	4	dissociating	dissociate	VERB
admet-1513	744	5	enzyme	enzyme	NOUN
admet-1513	744	6	thermolysin	thermolysin	NOUN
admet-1513	744	7	to	to	PART
admet-1513	744	8	generate	generate	VERB
admet-1513	744	9	viable	viable	ADJ
admet-1513	744	10	human	human	ADJ
admet-1513	744	11	normal	normal	ADJ
admet-1513	744	12	intestinal	intestinal	ADJ
admet-1513	744	13	epithelial	epithelial	ADJ
admet-1513	744	14	cell	cell	NOUN
admet-1513	744	15	cultures	culture	NOUN
admet-1513	744	16	.	.	PUNCT
admet-1513	745	1	exp	exp	NOUN
admet-1513	745	2	.	.	PUNCT
admet-1513	745	3	cell	cell	NOUN
admet-1513	745	4	res	re	NOUN
admet-1513	745	5	.	.	PUNCT
admet-1513	746	1	224	224	NUM
admet-1513	746	2	(	(	PUNCT
admet-1513	746	3	1996	1996	NUM
admet-1513	746	4	)	)	PUNCT
admet-1513	746	5	354	354	NUM
admet-1513	746	6	-	-	SYM
admet-1513	746	7	364	364	NUM
admet-1513	746	8	.	.	PUNCT
admet-1513	747	1	https://doi.org/10.1006/excr.1996.0145	https://doi.org/10.1006/excr.1996.0145	PROPN
admet-1513	747	2	.	.	PUNCT
admet-1513	748	1	[	[	X
admet-1513	748	2	49	49	NUM
admet-1513	748	3	]	]	PUNCT
admet-1513	748	4	t.	t.	PROPN
admet-1513	748	5	takenaka	takenaka	PROPN
admet-1513	748	6	,	,	PUNCT
admet-1513	748	7	n.	n.	PROPN
admet-1513	748	8	harada	harada	PROPN
admet-1513	748	9	,	,	PUNCT
admet-1513	748	10	j.	j.	PROPN
admet-1513	748	11	kuze	kuze	PROPN
admet-1513	748	12	,	,	PUNCT
admet-1513	748	13	m.	m.	PROPN
admet-1513	748	14	chiba	chiba	PROPN
admet-1513	748	15	,	,	PUNCT
admet-1513	748	16	t.	t.	PROPN
admet-1513	748	17	iwao	iwao	PROPN
admet-1513	748	18	,	,	PUNCT
admet-1513	748	19	t.	t.	PROPN
admet-1513	748	20	matsunaga	matsunaga	NOUN
admet-1513	748	21	.	.	PUNCT
admet-1513	749	1	application	application	NOUN
admet-1513	749	2	of	of	ADP
admet-1513	749	3	a	a	DET
admet-1513	749	4	human	human	ADJ
admet-1513	749	5	intestinal	intestinal	ADJ
admet-1513	749	6	epithelial	epithelial	ADJ
admet-1513	749	7	cell	cell	NOUN
admet-1513	749	8	monolayer	monolayer	NOUN
admet-1513	749	9	to	to	ADP
admet-1513	749	10	the	the	DET
admet-1513	749	11	prediction	prediction	NOUN
admet-1513	749	12	of	of	ADP
admet-1513	749	13	oral	oral	ADJ
admet-1513	749	14	drug	drug	NOUN
admet-1513	749	15	absorption	absorption	NOUN
admet-1513	749	16	in	in	ADP
admet-1513	749	17	humans	human	NOUN
admet-1513	749	18	as	as	ADP
admet-1513	749	19	a	a	DET
admet-1513	749	20	superior	superior	ADJ
admet-1513	749	21	alternative	alternative	NOUN
admet-1513	749	22	to	to	ADP
admet-1513	749	23	the	the	DET
admet-1513	749	24	caco-2	caco-2	NUM
admet-1513	749	25	cell	cell	NOUN
admet-1513	749	26	monolayer	monolayer	NOUN
admet-1513	749	27	.	.	PUNCT
admet-1513	750	1	j.	j.	PROPN
admet-1513	750	2	pharm	pharm	PROPN
admet-1513	750	3	.	.	PUNCT
admet-1513	751	1	sci	sci	PROPN
admet-1513	751	2	.	.	PROPN
admet-1513	752	1	105	105	NUM
admet-1513	752	2	(	(	PUNCT
admet-1513	752	3	2016	2016	NUM
admet-1513	752	4	)	)	PUNCT
admet-1513	752	5	915	915	NUM
admet-1513	752	6	-	-	SYM
admet-1513	752	7	924	924	NUM
admet-1513	752	8	.	.	PUNCT
admet-1513	753	1	https://doi.org/10.1016/j.xphs.2015.11.035	https://doi.org/10.1016/j.xphs.2015.11.035	NOUN
admet-1513	753	2	.	.	PUNCT
admet-1513	754	1	[	[	X
admet-1513	754	2	50	50	NUM
admet-1513	754	3	]	]	PUNCT
admet-1513	754	4	a.	a.	NOUN
admet-1513	754	5	mansoor	mansoor	PROPN
admet-1513	754	6	,	,	PUNCT
admet-1513	754	7	n.	n.	PROPN
admet-1513	754	8	mahabadi	mahabadi	PROPN
admet-1513	754	9	.	.	PUNCT
admet-1513	755	1	volume	volume	NOUN
admet-1513	755	2	of	of	ADP
admet-1513	755	3	distribution	distribution	NOUN
admet-1513	755	4	.	.	PUNCT
admet-1513	756	1	in	in	ADP
admet-1513	756	2	statpearls	statpearl	NOUN
admet-1513	757	1	[	[	X
admet-1513	757	2	internet	internet	NOUN
admet-1513	757	3	]	]	PUNCT
admet-1513	757	4	,	,	PUNCT
admet-1513	757	5	statpearls	statpearls	PROPN
admet-1513	757	6	publishing	publishing	NOUN
admet-1513	757	7	,	,	PUNCT
admet-1513	757	8	2021	2021	NUM
admet-1513	757	9	.	.	PUNCT
admet-1513	758	1	[	[	X
admet-1513	758	2	51	51	NUM
admet-1513	758	3	]	]	X
admet-1513	758	4	s.	s.	PROPN
admet-1513	758	5	alqahtani	alqahtani	PROPN
admet-1513	758	6	,	,	PUNCT
admet-1513	758	7	l.a	l.a	PROPN
admet-1513	758	8	.	.	PROPN
admet-1513	758	9	mohamed	mohamed	PROPN
admet-1513	758	10	,	,	PUNCT
admet-1513	758	11	a.	a.	PROPN
admet-1513	758	12	kaddoumi	kaddoumi	PROPN
admet-1513	758	13	.	.	PUNCT
admet-1513	759	1	experimental	experimental	ADJ
admet-1513	759	2	models	model	NOUN
admet-1513	759	3	for	for	ADP
admet-1513	759	4	predicting	predict	VERB
admet-1513	759	5	drug	drug	NOUN
admet-1513	759	6	absorption	absorption	NOUN
admet-1513	759	7	and	and	CCONJ
admet-1513	759	8	metabolism	metabolism	NOUN
admet-1513	759	9	.	.	PUNCT
admet-1513	760	1	expert	expert	NOUN
admet-1513	760	2	opin	opin	NOUN
admet-1513	760	3	.	.	PUNCT
admet-1513	761	1	drug	drug	NOUN
admet-1513	761	2	metab	metab	NOUN
admet-1513	761	3	.	.	PUNCT
admet-1513	762	1	toxicol	toxicol	PROPN
admet-1513	762	2	.	.	PUNCT
admet-1513	763	1	9	9	NUM
admet-1513	763	2	(	(	PUNCT
admet-1513	763	3	2013	2013	NUM
admet-1513	763	4	)	)	PUNCT
admet-1513	763	5	1241	1241	NUM
admet-1513	763	6	-	-	SYM
admet-1513	763	7	1254	1254	NUM
admet-1513	763	8	.	.	PUNCT
admet-1513	764	1	https://doi.org/10.1517/17425255.2013.802772	https://doi.org/10.1517/17425255.2013.802772	X
admet-1513	764	2	.	.	PUNCT
admet-1513	765	1	[	[	X
admet-1513	765	2	52	52	NUM
admet-1513	765	3	]	]	PUNCT
admet-1513	765	4	h.	h.	PROPN
admet-1513	765	5	wang	wang	PROPN
admet-1513	765	6	,	,	PUNCT
admet-1513	765	7	p.c	p.c	PROPN
admet-1513	765	8	.	.	PROPN
admet-1513	765	9	brown	brown	PROPN
admet-1513	765	10	,	,	PUNCT
admet-1513	765	11	e.c.y	e.c.y	PROPN
admet-1513	765	12	.	.	PROPN
admet-1513	765	13	chow	chow	PROPN
admet-1513	765	14	,	,	PUNCT
admet-1513	765	15	l.	l.	PROPN
admet-1513	765	16	ewart	ewart	PROPN
admet-1513	765	17	,	,	PUNCT
admet-1513	765	18	s.s	s.s	PROPN
admet-1513	765	19	.	.	PROPN
admet-1513	765	20	ferguson	ferguson	PROPN
admet-1513	765	21	,	,	PUNCT
admet-1513	765	22	s.	s.	PROPN
admet-1513	765	23	fitzpatrick	fitzpatrick	PROPN
admet-1513	765	24	,	,	PUNCT
admet-1513	765	25	b.s	b.s	PROPN
admet-1513	765	26	.	.	PROPN
admet-1513	765	27	freedman	freedman	PROPN
admet-1513	765	28	,	,	PUNCT
admet-1513	765	29	g.l	g.l	PROPN
admet-1513	765	30	.	.	PROPN
admet-1513	765	31	guo	guo	PROPN
admet-1513	765	32	,	,	PUNCT
admet-1513	765	33	w.	w.	PROPN
admet-1513	765	34	hedrich	hedrich	PROPN
admet-1513	765	35	,	,	PUNCT
admet-1513	765	36	s.	s.	PROPN
admet-1513	765	37	heyward	heyward	PROPN
admet-1513	765	38	,	,	PUNCT
admet-1513	765	39	j.	j.	PROPN
admet-1513	765	40	hickman	hickman	PROPN
admet-1513	765	41	,	,	PUNCT
admet-1513	765	42	n.	n.	PROPN
admet-1513	765	43	isoherranen	isoherranen	PROPN
admet-1513	765	44	,	,	PUNCT
admet-1513	765	45	a.p	a.p	PROPN
admet-1513	765	46	.	.	PROPN
admet-1513	765	47	li	li	PROPN
admet-1513	765	48	,	,	PUNCT
admet-1513	765	49	q.	q.	PROPN
admet-1513	765	50	liu	liu	PROPN
admet-1513	765	51	,	,	PUNCT
admet-1513	765	52	s.m	s.m	PROPN
admet-1513	765	53	.	.	PROPN
admet-1513	765	54	mumenthaler	mumenthaler	PROPN
admet-1513	765	55	,	,	PUNCT
admet-1513	765	56	j.	j.	PROPN
admet-1513	765	57	polli	polli	PROPN
admet-1513	765	58	,	,	PUNCT
admet-1513	765	59	w.r	w.r	PROPN
admet-1513	765	60	.	.	PROPN
admet-1513	765	61	proctor	proctor	PROPN
admet-1513	765	62	,	,	PUNCT
admet-1513	765	63	a.	a.	PROPN
admet-1513	765	64	ribeiro	ribeiro	PROPN
admet-1513	765	65	,	,	PUNCT
admet-1513	765	66	j.y	j.y	PROPN
admet-1513	765	67	.	.	PROPN
admet-1513	765	68	wang	wang	PROPN
admet-1513	765	69	,	,	PUNCT
admet-1513	765	70	r.l	r.l	PROPN
admet-1513	765	71	.	.	PROPN
admet-1513	765	72	wange	wange	PROPN
admet-1513	765	73	,	,	PUNCT
admet-1513	765	74	s.m	s.m	PROPN
admet-1513	765	75	.	.	PROPN
admet-1513	765	76	huang	huang	PROPN
admet-1513	765	77	.	.	PUNCT
admet-1513	766	1	3d	3d	PROPN
admet-1513	766	2	cell	cell	NOUN
admet-1513	766	3	culture	culture	NOUN
admet-1513	766	4	models	model	NOUN
admet-1513	766	5	:	:	PUNCT
admet-1513	766	6	drug	drug	NOUN
admet-1513	766	7	pharmacokinetics	pharmacokinetic	NOUN
admet-1513	766	8	,	,	PUNCT
admet-1513	766	9	safety	safety	NOUN
admet-1513	766	10	assessment	assessment	NOUN
admet-1513	766	11	,	,	PUNCT
admet-1513	766	12	and	and	CCONJ
admet-1513	766	13	regulatory	regulatory	ADJ
admet-1513	766	14	consideration	consideration	NOUN
admet-1513	766	15	.	.	PUNCT
admet-1513	767	1	clin	clin	PROPN
admet-1513	767	2	.	.	PUNCT
admet-1513	767	3	transl	transl	PROPN
admet-1513	767	4	.	.	PUNCT
admet-1513	768	1	sci	sci	PROPN
admet-1513	768	2	.	.	PROPN
admet-1513	768	3	14	14	NUM
admet-1513	768	4	(	(	PUNCT
admet-1513	768	5	2021	2021	NUM
admet-1513	768	6	)	)	PUNCT
admet-1513	768	7	16591680	16591680	NUM
admet-1513	768	8	.	.	PUNCT
admet-1513	769	1	https://doi.org/10.1111/cts.13066	https://doi.org/10.1111/cts.13066	PROPN
admet-1513	769	2	.	.	PUNCT
admet-1513	770	1	[	[	X
admet-1513	770	2	53	53	NUM
admet-1513	770	3	]	]	PUNCT
admet-1513	770	4	m.	m.	NOUN
admet-1513	770	5	bajpai	bajpai	PROPN
admet-1513	770	6	,	,	PUNCT
admet-1513	770	7	j.d	j.d	PROPN
admet-1513	770	8	.	.	PROPN
admet-1513	770	9	esmay	esmay	PROPN
admet-1513	770	10	.	.	PUNCT
admet-1513	771	1	in	in	ADP
admet-1513	771	2	vitro	vitro	X
admet-1513	771	3	studies	study	NOUN
admet-1513	771	4	in	in	ADP
admet-1513	771	5	drug	drug	NOUN
admet-1513	771	6	discovery	discovery	NOUN
admet-1513	771	7	and	and	CCONJ
admet-1513	771	8	development	development	NOUN
admet-1513	771	9	:	:	PUNCT
admet-1513	771	10	an	an	DET
admet-1513	771	11	analysis	analysis	NOUN
admet-1513	771	12	of	of	ADP
admet-1513	771	13	study	study	NOUN
admet-1513	771	14	objectives	objective	NOUN
admet-1513	771	15	and	and	CCONJ
admet-1513	771	16	application	application	NOUN
admet-1513	771	17	of	of	ADP
admet-1513	771	18	good	good	ADJ
admet-1513	771	19	laboratory	laboratory	NOUN
admet-1513	771	20	practices	practice	NOUN
admet-1513	771	21	(	(	PUNCT
admet-1513	771	22	glp	glp	NOUN
admet-1513	771	23	)	)	PUNCT
admet-1513	771	24	.	.	PUNCT
admet-1513	772	1	drug	drug	NOUN
admet-1513	772	2	metab	metab	PROPN
admet-1513	772	3	.	.	PUNCT
admet-1513	773	1	rev	rev	PROPN
admet-1513	773	2	.	.	PROPN
admet-1513	773	3	34	34	NUM
admet-1513	773	4	(	(	PUNCT
admet-1513	773	5	2002	2002	NUM
admet-1513	773	6	)	)	PUNCT
admet-1513	773	7	679	679	NUM
admet-1513	773	8	-	-	PUNCT
admet-1513	773	9	689	689	NUM
admet-1513	773	10	.	.	PUNCT
admet-1513	773	11	https://doi.org/10.1081/dmr-120015690	https://doi.org/10.1081/dmr-120015690	NOUN
admet-1513	773	12	.	.	PUNCT
admet-1513	774	1	[	[	X
admet-1513	774	2	54	54	NUM
admet-1513	774	3	]	]	X
admet-1513	774	4	f.p	f.p	PROPN
admet-1513	774	5	.	.	PROPN
admet-1513	774	6	guengerich	guengerich	NOUN
admet-1513	774	7	.	.	PUNCT
admet-1513	775	1	cytochrome	cytochrome	PROPN
admet-1513	775	2	p-450	p-450	PROPN
admet-1513	775	3	3a4	3a4	NUM
admet-1513	775	4	:	:	PUNCT
admet-1513	775	5	regulation	regulation	NOUN
admet-1513	775	6	and	and	CCONJ
admet-1513	775	7	role	role	NOUN
admet-1513	775	8	in	in	ADP
admet-1513	775	9	drug	drug	NOUN
admet-1513	775	10	metabolism	metabolism	NOUN
admet-1513	775	11	.	.	PUNCT
admet-1513	776	1	annu	annu	NOUN
admet-1513	776	2	.	.	PUNCT
admet-1513	777	1	rev	rev	PROPN
admet-1513	777	2	.	.	PROPN
admet-1513	777	3	pharmacol	pharmacol	PROPN
admet-1513	777	4	.	.	PUNCT
admet-1513	778	1	toxicol	toxicol	PROPN
admet-1513	778	2	.	.	PUNCT
admet-1513	779	1	39	39	NUM
admet-1513	779	2	(	(	PUNCT
admet-1513	779	3	1999	1999	NUM
admet-1513	779	4	)	)	PUNCT
admet-1513	779	5	1	1	NUM
admet-1513	779	6	-	-	SYM
admet-1513	779	7	17	17	NUM
admet-1513	779	8	.	.	PUNCT
admet-1513	780	1	https://doi.org/10.1146/annurev.pharmtox.39.1.1	https://doi.org/10.1146/annurev.pharmtox.39.1.1	X
admet-1513	780	2	.	.	PUNCT
admet-1513	781	1	[	[	X
admet-1513	781	2	55	55	NUM
admet-1513	781	3	]	]	X
admet-1513	781	4	g.r	g.r	PROPN
admet-1513	781	5	.	.	PROPN
admet-1513	781	6	valicherla	valicherla	PROPN
admet-1513	781	7	,	,	PUNCT
admet-1513	781	8	a.	a.	PROPN
admet-1513	781	9	mishra	mishra	PROPN
admet-1513	781	10	,	,	PUNCT
admet-1513	781	11	s.	s.	PROPN
admet-1513	781	12	lenkalapelly	lenkalapelly	PROPN
admet-1513	781	13	,	,	PUNCT
admet-1513	781	14	b.	b.	PROPN
admet-1513	781	15	jillela	jillela	PROPN
admet-1513	781	16	,	,	PUNCT
admet-1513	781	17	f.m	f.m	PROPN
admet-1513	781	18	.	.	PROPN
admet-1513	781	19	francis	francis	PROPN
admet-1513	781	20	,	,	PUNCT
admet-1513	781	21	l.	l.	PROPN
admet-1513	781	22	rajagopalan	rajagopalan	PROPN
admet-1513	781	23	,	,	PUNCT
admet-1513	781	24	p.	p.	PROPN
admet-1513	781	25	srivastava	srivastava	PROPN
admet-1513	781	26	.	.	PUNCT
admet-1513	782	1	investigation	investigation	NOUN
admet-1513	782	2	of	of	ADP
admet-1513	782	3	the	the	DET
admet-1513	782	4	inhibition	inhibition	NOUN
admet-1513	782	5	of	of	ADP
admet-1513	782	6	eight	eight	NUM
admet-1513	782	7	major	major	ADJ
admet-1513	782	8	human	human	ADJ
admet-1513	782	9	cytochrome	cytochrome	NOUN
admet-1513	782	10	p450	p450	NUM
admet-1513	782	11	isozymes	isozyme	NOUN
admet-1513	782	12	by	by	ADP
admet-1513	782	13	a	a	DET
admet-1513	782	14	probe	probe	NOUN
admet-1513	782	15	substrate	substrate	NOUN
admet-1513	782	16	cocktail	cocktail	NOUN
admet-1513	782	17	in	in	ADP
admet-1513	782	18	vitro	vitro	NOUN
admet-1513	782	19	with	with	ADP
admet-1513	782	20	emphasis	emphasis	NOUN
admet-1513	782	21	on	on	ADP
admet-1513	782	22	cyp2e1	cyp2e1	ADJ
admet-1513	782	23	.	.	PUNCT
admet-1513	783	1	xenobiotica	xenobiotica	PROPN
admet-1513	783	2	49	49	NUM
admet-1513	783	3	(	(	PUNCT
admet-1513	783	4	2019	2019	NUM
admet-1513	783	5	)	)	PUNCT
admet-1513	783	6	1396	1396	NUM
admet-1513	783	7	-	-	SYM
admet-1513	783	8	1402	1402	NUM
admet-1513	783	9	.	.	PUNCT
admet-1513	783	10	https://doi.org/10.1080/00498254.2019.1581301	https://doi.org/10.1080/00498254.2019.1581301	PUNCT
admet-1513	784	1	[	[	X
admet-1513	784	2	56	56	NUM
admet-1513	784	3	]	]	X
admet-1513	784	4	b.k	b.k	PROPN
admet-1513	784	5	.	.	PROPN
admet-1513	784	6	park	park	PROPN
admet-1513	784	7	,	,	PUNCT
admet-1513	784	8	n.r	n.r	PROPN
admet-1513	784	9	.	.	PROPN
admet-1513	784	10	kitteringham	kitteringham	PROPN
admet-1513	784	11	,	,	PUNCT
admet-1513	784	12	j.l	j.l	PROPN
admet-1513	784	13	.	.	PROPN
admet-1513	784	14	maggs	maggs	PROPN
admet-1513	784	15	,	,	PUNCT
admet-1513	784	16	m.	m.	NOUN
admet-1513	784	17	pirmohamed	pirmohame	VERB
admet-1513	784	18	,	,	PUNCT
admet-1513	784	19	d.p	d.p	PROPN
admet-1513	784	20	.	.	PROPN
admet-1513	784	21	williams	williams	PROPN
admet-1513	784	22	.	.	PUNCT
admet-1513	785	1	the	the	DET
admet-1513	785	2	role	role	NOUN
admet-1513	785	3	of	of	ADP
admet-1513	785	4	metabolic	metabolic	ADJ
admet-1513	785	5	activation	activation	NOUN
admet-1513	785	6	in	in	ADP
admet-1513	785	7	drug	drug	NOUN
admet-1513	785	8	-	-	PUNCT
admet-1513	785	9	induced	induce	VERB
admet-1513	785	10	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	785	11	.	.	PUNCT
admet-1513	785	12	annu	annu	PROPN
admet-1513	785	13	.	.	PUNCT
admet-1513	786	1	rev	rev	PROPN
admet-1513	786	2	.	.	PROPN
admet-1513	786	3	pharmacol	pharmacol	PROPN
admet-1513	786	4	.	.	PUNCT
admet-1513	787	1	toxicol	toxicol	PROPN
admet-1513	787	2	.	.	PUNCT
admet-1513	788	1	45	45	NUM
admet-1513	788	2	(	(	PUNCT
admet-1513	788	3	2005	2005	NUM
admet-1513	788	4	)	)	PUNCT
admet-1513	788	5	177	177	NUM
admet-1513	788	6	-	-	SYM
admet-1513	788	7	202	202	NUM
admet-1513	788	8	.	.	PUNCT
admet-1513	789	1	https://doi.org/10.1146/annurev.pharmtox.45.120403.100058	https://doi.org/10.1146/annurev.pharmtox.45.120403.100058	ADJ
admet-1513	789	2	.	.	PUNCT
admet-1513	790	1	[	[	X
admet-1513	790	2	57	57	NUM
admet-1513	790	3	]	]	X
admet-1513	790	4	m.n	m.n	PROPN
admet-1513	790	5	.	.	PROPN
admet-1513	790	6	berry	berry	PROPN
admet-1513	790	7	,	,	PUNCT
admet-1513	790	8	a.r	a.r	PROPN
admet-1513	790	9	.	.	PROPN
admet-1513	790	10	grivell	grivell	PROPN
admet-1513	790	11	,	,	PUNCT
admet-1513	790	12	m.b	m.b	PROPN
admet-1513	790	13	.	.	PROPN
admet-1513	790	14	grivell	grivell	PROPN
admet-1513	790	15	,	,	PUNCT
admet-1513	790	16	j.w	j.w	PROPN
admet-1513	790	17	.	.	PROPN
admet-1513	790	18	phillips	phillips	PROPN
admet-1513	790	19	.	.	PUNCT
admet-1513	791	1	isolated	isolate	VERB
admet-1513	791	2	hepatocytes	hepatocyte	NOUN
admet-1513	791	3	-	-	PUNCT
admet-1513	791	4	past	past	NOUN
admet-1513	791	5	,	,	PUNCT
admet-1513	791	6	present	present	ADJ
admet-1513	791	7	and	and	CCONJ
admet-1513	791	8	future	future	NOUN
admet-1513	791	9	.	.	PUNCT
admet-1513	792	1	cell	cell	NOUN
admet-1513	792	2	biol	biol	PROPN
admet-1513	792	3	.	.	PUNCT
admet-1513	793	1	toxicol	toxicol	PROPN
admet-1513	793	2	.	.	PUNCT
admet-1513	794	1	13(4	13(4	NUM
admet-1513	794	2	)	)	PUNCT
admet-1513	794	3	(	(	PUNCT
admet-1513	794	4	1997	1997	NUM
admet-1513	794	5	)	)	PUNCT
admet-1513	794	6	223	223	NUM
admet-1513	794	7	-	-	SYM
admet-1513	794	8	233	233	NUM
admet-1513	794	9	.	.	PUNCT
admet-1513	795	1	https://doi.org/10.1023/a:1007402505482	https://doi.org/10.1023/a:1007402505482	PROPN
admet-1513	795	2	.	.	PUNCT
admet-1513	796	1	[	[	X
admet-1513	796	2	58	58	NUM
admet-1513	796	3	]	]	X
admet-1513	796	4	i.	i.	PROPN
admet-1513	796	5	schaeffner	schaeffner	PROPN
admet-1513	796	6	,	,	PUNCT
admet-1513	796	7	j.	j.	PROPN
admet-1513	796	8	petters	petters	PROPN
admet-1513	796	9	,	,	PUNCT
admet-1513	796	10	h.	h.	PROPN
admet-1513	796	11	aurich	aurich	PROPN
admet-1513	796	12	,	,	PUNCT
admet-1513	796	13	p.	p.	PROPN
admet-1513	796	14	frohberg	frohberg	PROPN
admet-1513	796	15	,	,	PUNCT
admet-1513	796	16	b.	b.	PROPN
admet-1513	796	17	christ	christ	PROPN
admet-1513	796	18	.	.	PUNCT
admet-1513	797	1	a	a	DET
admet-1513	797	2	microtiterplate	microtiterplate	NOUN
admet-1513	797	3	-	-	PUNCT
admet-1513	797	4	based	base	VERB
admet-1513	797	5	screening	screening	NOUN
admet-1513	797	6	assay	assay	VERB
admet-1513	797	7	to	to	PART
admet-1513	797	8	assess	assess	VERB
admet-1513	797	9	diverse	diverse	ADJ
admet-1513	797	10	effects	effect	NOUN
admet-1513	797	11	on	on	ADP
admet-1513	797	12	cytochrome	cytochrome	ADJ
admet-1513	797	13	p450	p450	ADJ
admet-1513	797	14	enzyme	enzyme	NOUN
admet-1513	797	15	activities	activity	NOUN
admet-1513	797	16	in	in	ADP
admet-1513	797	17	primary	primary	ADJ
admet-1513	797	18	rat	rat	NOUN
admet-1513	797	19	hepatocytes	hepatocyte	NOUN
admet-1513	797	20	by	by	ADP
admet-1513	797	21	various	various	ADJ
admet-1513	797	22	compounds	compound	NOUN
admet-1513	797	23	.	.	PUNCT
admet-1513	798	1	assay	assay	PROPN
admet-1513	798	2	drug	drug	PROPN
admet-1513	798	3	dev	dev	PROPN
admet-1513	798	4	.	.	PUNCT
admet-1513	799	1	technol	technol	PROPN
admet-1513	799	2	.	.	PUNCT
admet-1513	800	1	3(1	3(1	NUM
admet-1513	800	2	)	)	PUNCT
admet-1513	800	3	(	(	PUNCT
admet-1513	800	4	2005	2005	NUM
admet-1513	800	5	)	)	PUNCT
admet-1513	800	6	27	27	NUM
admet-1513	800	7	-	-	SYM
admet-1513	800	8	38	38	NUM
admet-1513	800	9	.	.	PUNCT
admet-1513	801	1	https://doi.org/10.1089/adt.2005.3.27	https://doi.org/10.1089/adt.2005.3.27	PROPN
admet-1513	801	2	.	.	PROPN
admet-1513	801	3	https://doi.org/10.1007/s10495-013-0944-1	https://doi.org/10.1007/s10495-013-0944-1	NUM
admet-1513	802	1	https://doi.org/10.1590/s0100-879x2010007500036	https://doi.org/10.1590/s0100-879x2010007500036	X
admet-1513	803	1	https://doi.org/10.1006/excr.1996.0145	https://doi.org/10.1006/excr.1996.0145	PROPN
admet-1513	803	2	https://doi.org/10.1006/excr.1996.0145	https://doi.org/10.1006/excr.1996.0145	PROPN
admet-1513	803	3	https://doi.org/10.1016/j.xphs.2015.11.035	https://doi.org/10.1016/j.xphs.2015.11.035	ADJ
admet-1513	803	4	https://doi.org/10.1016/j.xphs.2015.11.035	https://doi.org/10.1016/j.xphs.2015.11.035	NOUN
admet-1513	803	5	https://doi.org/10.1517/17425255.2013.802772	https://doi.org/10.1517/17425255.2013.802772	PUNCT
admet-1513	803	6	https://doi.org/10.1517/17425255.2013.802772	https://doi.org/10.1517/17425255.2013.802772	PUNCT
admet-1513	804	1	https://doi.org/10.1111/cts.13066	https://doi.org/10.1111/cts.13066	PROPN
admet-1513	804	2	https://doi.org/10.1081/dmr-120015690	https://doi.org/10.1081/dmr-120015690	X
admet-1513	804	3	https://doi.org/10.1146/annurev.pharmtox.39.1.1	https://doi.org/10.1146/annurev.pharmtox.39.1.1	X
admet-1513	804	4	https://doi.org/10.1080/00498254.2019.1581301	https://doi.org/10.1080/00498254.2019.1581301	X
admet-1513	804	5	https://doi.org/10.1080/00498254.2019.1581301	https://doi.org/10.1080/00498254.2019.1581301	PROPN
admet-1513	805	1	https://doi.org/10.1146/annurev.pharmtox.45.120403.100058	https://doi.org/10.1146/annurev.pharmtox.45.120403.100058	PROPN
admet-1513	805	2	https://doi.org/10.1023/a:1007402505482	https://doi.org/10.1023/a:1007402505482	PROPN
admet-1513	805	3	https://doi.org/10.1089/adt.2005.3.27	https://doi.org/10.1089/adt.2005.3.27	PROPN
admet-1513	805	4	admet	admet	PROPN
admet-1513	805	5	&	&	CCONJ
admet-1513	805	6	dmpk	dmpk	PROPN
admet-1513	805	7	11(1	11(1	NUM
admet-1513	805	8	)	)	PUNCT
admet-1513	805	9	(	(	PUNCT
admet-1513	805	10	2023	2023	NUM
admet-1513	805	11	)	)	PUNCT
admet-1513	805	12	1	1	NUM
admet-1513	805	13	-	-	SYM
admet-1513	805	14	32	32	NUM
admet-1513	805	15	2d	2d	NOUN
admet-1513	805	16	and	and	CCONJ
admet-1513	805	17	3d	3d	NOUN
admet-1513	805	18	adme	adme	PROPN
admet-1513	805	19	-	-	PUNCT
admet-1513	805	20	tox	tox	NOUN
admet-1513	805	21	cell	cell	NOUN
admet-1513	805	22	culture	culture	NOUN
admet-1513	805	23	screening	screen	VERB
admet-1513	805	24	:	:	PUNCT
admet-1513	805	25	a	a	DET
admet-1513	805	26	review	review	NOUN
admet-1513	805	27	doi	doi	NOUN
admet-1513	805	28	:	:	PUNCT
admet-1513	805	29	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	805	30	21	21	NUM
admet-1513	805	31	[	[	SYM
admet-1513	805	32	59	59	NUM
admet-1513	805	33	]	]	X
admet-1513	805	34	d.f	d.f	PROPN
admet-1513	805	35	.	.	PROPN
admet-1513	805	36	mcginnity	mcginnity	PROPN
admet-1513	805	37	,	,	PUNCT
admet-1513	805	38	m.g	m.g	PROPN
admet-1513	805	39	.	.	PROPN
admet-1513	805	40	soars	soars	PROPN
admet-1513	805	41	,	,	PUNCT
admet-1513	805	42	r.a	r.a	PROPN
admet-1513	805	43	.	.	PROPN
admet-1513	805	44	urbanowicz	urbanowicz	PROPN
admet-1513	805	45	,	,	PUNCT
admet-1513	805	46	r.j	r.j	PROPN
admet-1513	805	47	.	.	PROPN
admet-1513	805	48	riley	riley	PROPN
admet-1513	805	49	.	.	PUNCT
admet-1513	805	50	evaluation	evaluation	NOUN
admet-1513	805	51	of	of	ADP
admet-1513	805	52	fresh	fresh	ADJ
admet-1513	805	53	and	and	CCONJ
admet-1513	805	54	cryopreserved	cryopreserved	ADJ
admet-1513	805	55	hepatocytes	hepatocyte	NOUN
admet-1513	805	56	as	as	ADP
admet-1513	805	57	in	in	ADP
admet-1513	805	58	vitro	vitro	X
admet-1513	805	59	drug	drug	NOUN
admet-1513	805	60	metabolism	metabolism	NOUN
admet-1513	805	61	tools	tool	NOUN
admet-1513	805	62	for	for	ADP
admet-1513	805	63	the	the	DET
admet-1513	805	64	prediction	prediction	NOUN
admet-1513	805	65	of	of	ADP
admet-1513	805	66	metabolic	metabolic	NOUN
admet-1513	805	67	clearance	clearance	NOUN
admet-1513	805	68	.	.	PUNCT
admet-1513	806	1	drug	drug	NOUN
admet-1513	806	2	metab	metab	NOUN
admet-1513	806	3	.	.	PUNCT
admet-1513	807	1	dispos	dispos	PROPN
admet-1513	807	2	.	.	PUNCT
admet-1513	808	1	32	32	NUM
admet-1513	808	2	(	(	PUNCT
admet-1513	808	3	2004	2004	NUM
admet-1513	808	4	)	)	PUNCT
admet-1513	808	5	1247	1247	NUM
admet-1513	808	6	-	-	SYM
admet-1513	808	7	1253	1253	NUM
admet-1513	808	8	.	.	PUNCT
admet-1513	809	1	https://doi.org/10.1124/dmd.104.000026	https://doi.org/10.1124/dmd.104.000026	PROPN
admet-1513	809	2	.	.	PUNCT
admet-1513	810	1	[	[	X
admet-1513	810	2	60	60	NUM
admet-1513	810	3	]	]	X
admet-1513	810	4	n.j	n.j	PROPN
admet-1513	810	5	.	.	PROPN
admet-1513	810	6	hewitt	hewitt	PROPN
admet-1513	810	7	,	,	PUNCT
admet-1513	810	8	k.u	k.u	PROPN
admet-1513	810	9	.	.	PROPN
admet-1513	810	10	bühring	bühring	NOUN
admet-1513	810	11	,	,	PUNCT
admet-1513	810	12	j.	j.	PROPN
admet-1513	810	13	dasenbrock	dasenbrock	PROPN
admet-1513	810	14	,	,	PUNCT
admet-1513	810	15	j.	j.	PROPN
admet-1513	810	16	haunschild	haunschild	PROPN
admet-1513	810	17	,	,	PUNCT
admet-1513	810	18	b.	b.	PROPN
admet-1513	810	19	ladstetter	ladstetter	PROPN
admet-1513	810	20	,	,	PUNCT
admet-1513	810	21	d.	d.	PROPN
admet-1513	810	22	utesch	utesch	PROPN
admet-1513	810	23	.	.	PUNCT
admet-1513	811	1	studies	study	NOUN
admet-1513	811	2	comparing	compare	VERB
admet-1513	811	3	in	in	ADP
admet-1513	811	4	vivo	vivo	NOUN
admet-1513	811	5	:	:	PUNCT
admet-1513	811	6	in	in	ADP
admet-1513	811	7	vitro	vitro	X
admet-1513	811	8	metabolism	metabolism	NOUN
admet-1513	811	9	of	of	ADP
admet-1513	811	10	three	three	NUM
admet-1513	811	11	pharmaceutical	pharmaceutical	ADJ
admet-1513	811	12	compounds	compound	NOUN
admet-1513	811	13	in	in	ADP
admet-1513	811	14	rat	rat	NOUN
admet-1513	811	15	,	,	PUNCT
admet-1513	811	16	dog	dog	NOUN
admet-1513	811	17	,	,	PUNCT
admet-1513	811	18	monkey	monkey	NOUN
admet-1513	811	19	,	,	PUNCT
admet-1513	811	20	and	and	CCONJ
admet-1513	811	21	human	human	ADJ
admet-1513	811	22	using	use	VERB
admet-1513	811	23	cryopreserved	cryopreserve	VERB
admet-1513	811	24	hepatocytes	hepatocyte	NOUN
admet-1513	811	25	,	,	PUNCT
admet-1513	811	26	microsomes	microsome	NOUN
admet-1513	811	27	,	,	PUNCT
admet-1513	811	28	and	and	CCONJ
admet-1513	811	29	collagen	collagen	NOUN
admet-1513	811	30	gel	gel	NOUN
admet-1513	811	31	immobilized	immobilize	VERB
admet-1513	811	32	hepatocyte	hepatocyte	NOUN
admet-1513	811	33	cultures	culture	NOUN
admet-1513	811	34	.	.	PUNCT
admet-1513	812	1	drug	drug	NOUN
admet-1513	812	2	metab	metab	NOUN
admet-1513	812	3	.	.	PUNCT
admet-1513	813	1	dispos	dispos	PROPN
admet-1513	813	2	.	.	PUNCT
admet-1513	814	1	29	29	NUM
admet-1513	814	2	(	(	PUNCT
admet-1513	814	3	2001	2001	NUM
admet-1513	814	4	)	)	PUNCT
admet-1513	814	5	1042	1042	NUM
admet-1513	814	6	-	-	SYM
admet-1513	814	7	1050	1050	NUM
admet-1513	814	8	.	.	PUNCT
admet-1513	815	1	[	[	X
admet-1513	815	2	61	61	NUM
admet-1513	815	3	]	]	X
admet-1513	815	4	j.s	j.s	PROPN
admet-1513	815	5	.	.	PROPN
admet-1513	815	6	salonen	salonen	PROPN
admet-1513	815	7	,	,	PUNCT
admet-1513	815	8	l.	l.	PROPN
admet-1513	815	9	nyman	nyman	PROPN
admet-1513	815	10	,	,	PUNCT
admet-1513	815	11	a.r	a.r	PROPN
admet-1513	815	12	.	.	PROPN
admet-1513	815	13	boobis	boobis	PROPN
admet-1513	815	14	,	,	PUNCT
admet-1513	815	15	r.j	r.j	PROPN
admet-1513	815	16	.	.	PROPN
admet-1513	815	17	edwards	edwards	PROPN
admet-1513	815	18	,	,	PUNCT
admet-1513	815	19	p.	p.	PROPN
admet-1513	815	20	watts	watts	PROPN
admet-1513	815	21	,	,	PUNCT
admet-1513	815	22	b.g	b.g	PROPN
admet-1513	815	23	.	.	PROPN
admet-1513	815	24	lake	lake	PROPN
admet-1513	815	25	,	,	PUNCT
admet-1513	815	26	r.j	r.j	PROPN
admet-1513	815	27	.	.	PROPN
admet-1513	815	28	price	price	NOUN
admet-1513	815	29	,	,	PUNCT
admet-1513	815	30	a.b	a.b	PROPN
admet-1513	815	31	.	.	PROPN
admet-1513	815	32	renwick	renwick	PROPN
admet-1513	815	33	,	,	PUNCT
admet-1513	815	34	m.j	m.j	PROPN
admet-1513	815	35	.	.	PROPN
admet-1513	815	36	gómez	gómez	PROPN
admet-1513	815	37	-	-	PUNCT
admet-1513	815	38	lechón	lechón	PROPN
admet-1513	815	39	,	,	PUNCT
admet-1513	815	40	j.v	j.v	PROPN
admet-1513	815	41	.	.	PROPN
admet-1513	815	42	castell	castell	PROPN
admet-1513	815	43	,	,	PUNCT
admet-1513	815	44	m.	m.	NOUN
admet-1513	815	45	ingelman	ingelman	NOUN
admet-1513	815	46	-	-	PUNCT
admet-1513	815	47	sundberg	sundberg	PROPN
admet-1513	815	48	,	,	PUNCT
admet-1513	815	49	m.	m.	NOUN
admet-1513	815	50	hidestrand	hidestrand	PROPN
admet-1513	815	51	,	,	PUNCT
admet-1513	815	52	a.	a.	NOUN
admet-1513	815	53	guillouzo	guillouzo	PROPN
admet-1513	815	54	,	,	PUNCT
admet-1513	815	55	l.	l.	PROPN
admet-1513	815	56	corcos	corcos	PROPN
admet-1513	815	57	,	,	PUNCT
admet-1513	815	58	p.s	p.s	PROPN
admet-1513	815	59	.	.	PUNCT
admet-1513	815	60	goldfarb	goldfarb	PROPN
admet-1513	815	61	,	,	PUNCT
admet-1513	815	62	d.f	d.f	PROPN
admet-1513	815	63	.	.	PROPN
admet-1513	815	64	lewis	lewis	PROPN
admet-1513	815	65	,	,	PUNCT
admet-1513	815	66	p.	p.	NOUN
admet-1513	815	67	taavitsainen	taavitsainen	PROPN
admet-1513	815	68	,	,	PUNCT
admet-1513	815	69	o.	o.	PROPN
admet-1513	815	70	pelkonen	pelkonen	NOUN
admet-1513	815	71	.	.	PUNCT
admet-1513	816	1	comparative	comparative	ADJ
admet-1513	816	2	studies	study	NOUN
admet-1513	816	3	on	on	ADP
admet-1513	816	4	the	the	DET
admet-1513	816	5	cytochrome	cytochrome	NOUN
admet-1513	816	6	p450associated	p450associate	VERB
admet-1513	816	7	metabolism	metabolism	NOUN
admet-1513	816	8	and	and	CCONJ
admet-1513	816	9	interaction	interaction	NOUN
admet-1513	816	10	potential	potential	NOUN
admet-1513	816	11	of	of	ADP
admet-1513	816	12	selegiline	selegiline	NOUN
admet-1513	816	13	between	between	ADP
admet-1513	816	14	human	human	ADJ
admet-1513	816	15	liver	liver	NOUN
admet-1513	816	16	-	-	PUNCT
admet-1513	816	17	derived	derive	VERB
admet-1513	816	18	in	in	ADP
admet-1513	816	19	vitro	vitro	X
admet-1513	816	20	systems	system	NOUN
admet-1513	816	21	.	.	PUNCT
admet-1513	817	1	drug	drug	NOUN
admet-1513	817	2	metab	metab	NOUN
admet-1513	817	3	.	.	PUNCT
admet-1513	818	1	dispos	dispos	PROPN
admet-1513	818	2	.	.	PUNCT
admet-1513	819	1	31	31	NUM
admet-1513	819	2	(	(	PUNCT
admet-1513	819	3	2003	2003	NUM
admet-1513	819	4	)	)	PUNCT
admet-1513	819	5	1093	1093	NUM
admet-1513	819	6	-	-	SYM
admet-1513	819	7	1102	1102	NUM
admet-1513	819	8	.	.	PUNCT
admet-1513	820	1	https://doi.org/10.1124/dmd.31.9.1093	https://doi.org/10.1124/dmd.31.9.1093	NOUN
admet-1513	820	2	.	.	PUNCT
admet-1513	821	1	[	[	X
admet-1513	821	2	62	62	NUM
admet-1513	821	3	]	]	X
admet-1513	821	4	j.b	j.b	PROPN
admet-1513	821	5	.	.	PROPN
admet-1513	821	6	ferrini	ferrini	PROPN
admet-1513	821	7	,	,	PUNCT
admet-1513	821	8	l.	l.	PROPN
admet-1513	821	9	pichard	pichard	PROPN
admet-1513	821	10	,	,	PUNCT
admet-1513	821	11	j.	j.	PROPN
admet-1513	821	12	domergue	domergue	PROPN
admet-1513	821	13	,	,	PUNCT
admet-1513	821	14	p.	p.	NOUN
admet-1513	821	15	maurel	maurel	NOUN
admet-1513	821	16	.	.	PUNCT
admet-1513	822	1	long	long	ADJ
admet-1513	822	2	-	-	PUNCT
admet-1513	822	3	term	term	NOUN
admet-1513	822	4	primary	primary	ADJ
admet-1513	822	5	cultures	culture	NOUN
admet-1513	822	6	of	of	ADP
admet-1513	822	7	adult	adult	NOUN
admet-1513	822	8	human	human	ADJ
admet-1513	822	9	hepatocytes	hepatocyte	NOUN
admet-1513	822	10	.	.	PUNCT
admet-1513	823	1	chem	chem	NOUN
admet-1513	823	2	.	.	PUNCT
admet-1513	824	1	biol	biol	PROPN
admet-1513	824	2	.	.	PUNCT
admet-1513	825	1	interact	interact	VERB
admet-1513	825	2	107	107	NUM
admet-1513	825	3	(	(	PUNCT
admet-1513	825	4	1997	1997	NUM
admet-1513	825	5	)	)	PUNCT
admet-1513	825	6	31	31	NUM
admet-1513	825	7	-	-	SYM
admet-1513	825	8	45	45	NUM
admet-1513	825	9	.	.	PUNCT
admet-1513	826	1	https://doi.org/10.1016/s0009-2797(97)000720	https://doi.org/10.1016/s0009-2797(97)000720	NOUN
admet-1513	826	2	.	.	PUNCT
admet-1513	827	1	[	[	X
admet-1513	827	2	63	63	NUM
admet-1513	827	3	]	]	SYM
admet-1513	827	4	m.j	m.j	PROPN
admet-1513	827	5	.	.	PROPN
admet-1513	827	6	gómez	gómez	PROPN
admet-1513	827	7	-	-	PUNCT
admet-1513	827	8	lechón	lechón	PROPN
admet-1513	827	9	,	,	PUNCT
admet-1513	827	10	m.t	m.t	PROPN
admet-1513	827	11	.	.	PROPN
admet-1513	827	12	donato	donato	PROPN
admet-1513	827	13	,	,	PUNCT
admet-1513	827	14	j.v	j.v	PROPN
admet-1513	827	15	.	.	PROPN
admet-1513	827	16	castell	castell	PROPN
admet-1513	827	17	,	,	PUNCT
admet-1513	827	18	r.	r.	PROPN
admet-1513	827	19	jover	jover	PROPN
admet-1513	827	20	.	.	PUNCT
admet-1513	828	1	human	human	ADJ
admet-1513	828	2	hepatocytes	hepatocyte	NOUN
admet-1513	828	3	in	in	ADP
admet-1513	828	4	primary	primary	ADJ
admet-1513	828	5	culture	culture	NOUN
admet-1513	828	6	:	:	PUNCT
admet-1513	828	7	the	the	DET
admet-1513	828	8	choice	choice	NOUN
admet-1513	828	9	to	to	PART
admet-1513	828	10	investigate	investigate	VERB
admet-1513	828	11	drug	drug	NOUN
admet-1513	828	12	metabolism	metabolism	NOUN
admet-1513	828	13	in	in	ADP
admet-1513	828	14	man	man	NOUN
admet-1513	828	15	.	.	PUNCT
admet-1513	829	1	curr	curr	PROPN
admet-1513	829	2	.	.	PUNCT
admet-1513	829	3	drug	drug	PROPN
admet-1513	829	4	metab	metab	NOUN
admet-1513	829	5	.	.	PUNCT
admet-1513	830	1	5	5	NUM
admet-1513	830	2	(	(	PUNCT
admet-1513	830	3	2004	2004	NUM
admet-1513	830	4	)	)	PUNCT
admet-1513	830	5	443	443	NUM
admet-1513	830	6	-	-	SYM
admet-1513	830	7	462	462	NUM
admet-1513	830	8	.	.	PUNCT
admet-1513	830	9	https://doi.org/10.2174/1389200043335414	https://doi.org/10.2174/1389200043335414	NOUN
admet-1513	830	10	.	.	PUNCT
admet-1513	831	1	[	[	X
admet-1513	831	2	64	64	NUM
admet-1513	831	3	]	]	X
admet-1513	831	4	m.j	m.j	PROPN
admet-1513	831	5	.	.	PROPN
admet-1513	831	6	gómez	gómez	PROPN
admet-1513	831	7	-	-	PUNCT
admet-1513	831	8	lechón	lechón	PROPN
admet-1513	831	9	,	,	PUNCT
admet-1513	831	10	j.v	j.v	PROPN
admet-1513	831	11	.	.	PROPN
admet-1513	831	12	castell	castell	PROPN
admet-1513	831	13	,	,	PUNCT
admet-1513	831	14	m.t	m.t	PROPN
admet-1513	831	15	.	.	PROPN
admet-1513	831	16	donato	donato	PROPN
admet-1513	831	17	.	.	PUNCT
admet-1513	832	1	hepatocytes	hepatocytes	PROPN
admet-1513	832	2	--	--	PUNCT
admet-1513	832	3	the	the	DET
admet-1513	832	4	choice	choice	NOUN
admet-1513	832	5	to	to	PART
admet-1513	832	6	investigate	investigate	VERB
admet-1513	832	7	drug	drug	NOUN
admet-1513	832	8	metabolism	metabolism	NOUN
admet-1513	832	9	and	and	CCONJ
admet-1513	832	10	toxicity	toxicity	NOUN
admet-1513	832	11	in	in	ADP
admet-1513	832	12	man	man	NOUN
admet-1513	832	13	:	:	PUNCT
admet-1513	832	14	in	in	ADP
admet-1513	832	15	vitro	vitro	X
admet-1513	832	16	variability	variability	NOUN
admet-1513	832	17	as	as	ADP
admet-1513	832	18	a	a	DET
admet-1513	832	19	reflection	reflection	NOUN
admet-1513	832	20	of	of	ADP
admet-1513	832	21	in	in	ADP
admet-1513	832	22	vivo	vivo	NOUN
admet-1513	832	23	.	.	PUNCT
admet-1513	833	1	chem	chem	NOUN
admet-1513	833	2	.	.	PUNCT
admet-1513	834	1	biol	biol	PROPN
admet-1513	834	2	.	.	PUNCT
admet-1513	835	1	interact	interact	VERB
admet-1513	835	2	.	.	PUNCT
admet-1513	836	1	168	168	NUM
admet-1513	836	2	(	(	PUNCT
admet-1513	836	3	2007	2007	NUM
admet-1513	836	4	)	)	PUNCT
admet-1513	836	5	30	30	NUM
admet-1513	836	6	-	-	SYM
admet-1513	836	7	50	50	NUM
admet-1513	836	8	.	.	PUNCT
admet-1513	837	1	https://doi.org/10.1016/j.cbi.2006.10.013	https://doi.org/10.1016/j.cbi.2006.10.013	PROPN
admet-1513	837	2	.	.	PUNCT
admet-1513	838	1	[	[	X
admet-1513	838	2	65	65	NUM
admet-1513	838	3	]	]	X
admet-1513	838	4	r.r	r.r	PROPN
admet-1513	838	5	.	.	PROPN
admet-1513	838	6	mitry	mitry	PROPN
admet-1513	838	7	,	,	PUNCT
admet-1513	838	8	r.d	r.d	PROPN
admet-1513	838	9	.	.	PROPN
admet-1513	838	10	hughes	hughes	PROPN
admet-1513	838	11	,	,	PUNCT
admet-1513	838	12	a.	a.	NOUN
admet-1513	838	13	dhawan	dhawan	PROPN
admet-1513	838	14	.	.	PUNCT
admet-1513	839	1	progress	progress	NOUN
admet-1513	839	2	in	in	ADP
admet-1513	839	3	human	human	ADJ
admet-1513	839	4	hepatocytes	hepatocyte	NOUN
admet-1513	839	5	:	:	PUNCT
admet-1513	839	6	isolation	isolation	NOUN
admet-1513	839	7	,	,	PUNCT
admet-1513	839	8	culture	culture	NOUN
admet-1513	839	9	&	&	CCONJ
admet-1513	839	10	cryopreservation	cryopreservation	PROPN
admet-1513	839	11	.	.	PUNCT
admet-1513	840	1	semin	semin	PROPN
admet-1513	840	2	.	.	PUNCT
admet-1513	841	1	cell	cell	PROPN
admet-1513	841	2	dev	dev	PROPN
admet-1513	841	3	.	.	PUNCT
admet-1513	842	1	biol	biol	PROPN
admet-1513	842	2	.	.	PUNCT
admet-1513	843	1	13	13	NUM
admet-1513	843	2	(	(	PUNCT
admet-1513	843	3	2002	2002	NUM
admet-1513	843	4	)	)	PUNCT
admet-1513	843	5	463	463	NUM
admet-1513	843	6	-	-	SYM
admet-1513	843	7	467	467	NUM
admet-1513	843	8	.	.	PUNCT
admet-1513	844	1	https://doi.org/10.1016/s1084952102001350	https://doi.org/10.1016/s1084952102001350	PROPN
admet-1513	844	2	.	.	PUNCT
admet-1513	845	1	[	[	X
admet-1513	845	2	66	66	NUM
admet-1513	845	3	]	]	PUNCT
admet-1513	845	4	t.	t.	PROPN
admet-1513	845	5	de	de	PROPN
admet-1513	845	6	bruyn	bruyn	PROPN
admet-1513	845	7	,	,	PUNCT
admet-1513	845	8	s.	s.	PROPN
admet-1513	845	9	chatterjee	chatterjee	PROPN
admet-1513	845	10	,	,	PUNCT
admet-1513	845	11	s.	s.	PROPN
admet-1513	845	12	fattah	fattah	PROPN
admet-1513	845	13	,	,	PUNCT
admet-1513	845	14	j.	j.	PROPN
admet-1513	845	15	keemink	keemink	PROPN
admet-1513	845	16	,	,	PUNCT
admet-1513	845	17	j.	j.	PROPN
admet-1513	845	18	nicolaï	nicolaï	PROPN
admet-1513	845	19	,	,	PUNCT
admet-1513	845	20	p.	p.	NOUN
admet-1513	845	21	augustijns	augustijns	NOUN
admet-1513	845	22	,	,	PUNCT
admet-1513	845	23	p.	p.	PROPN
admet-1513	845	24	annaert	annaert	NOUN
admet-1513	845	25	.	.	PUNCT
admet-1513	845	26	sandwichcultured	sandwichculture	VERB
admet-1513	845	27	hepatocytes	hepatocyte	NOUN
admet-1513	845	28	:	:	PUNCT
admet-1513	845	29	utility	utility	NOUN
admet-1513	845	30	for	for	ADP
admet-1513	845	31	in	in	ADP
admet-1513	845	32	vitro	vitro	X
admet-1513	845	33	exploration	exploration	NOUN
admet-1513	845	34	of	of	ADP
admet-1513	845	35	hepatobiliary	hepatobiliary	ADJ
admet-1513	845	36	drug	drug	NOUN
admet-1513	845	37	disposition	disposition	NOUN
admet-1513	845	38	and	and	CCONJ
admet-1513	845	39	druginduced	druginduce	VERB
admet-1513	845	40	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	845	41	.	.	PUNCT
admet-1513	846	1	expert	expert	NOUN
admet-1513	846	2	opin	opin	NOUN
admet-1513	846	3	.	.	PUNCT
admet-1513	847	1	drug	drug	NOUN
admet-1513	847	2	metab	metab	NOUN
admet-1513	847	3	.	.	PUNCT
admet-1513	848	1	toxicol	toxicol	PROPN
admet-1513	848	2	.	.	PUNCT
admet-1513	849	1	9	9	NUM
admet-1513	849	2	(	(	PUNCT
admet-1513	849	3	2013	2013	NUM
admet-1513	849	4	)	)	PUNCT
admet-1513	849	5	589	589	NUM
admet-1513	849	6	-	-	SYM
admet-1513	849	7	616	616	NUM
admet-1513	849	8	.	.	PUNCT
admet-1513	850	1	https://doi.org/10.1517/17425255.2013.773973	https://doi.org/10.1517/17425255.2013.773973	X
admet-1513	850	2	.	.	PUNCT
admet-1513	851	1	[	[	X
admet-1513	851	2	67	67	NUM
admet-1513	851	3	]	]	X
admet-1513	851	4	b.	b.	PROPN
admet-1513	851	5	swift	swift	PROPN
admet-1513	851	6	,	,	PUNCT
admet-1513	851	7	n.d	n.d	PROPN
admet-1513	851	8	.	.	PROPN
admet-1513	851	9	pfeifer	pfeifer	PROPN
admet-1513	851	10	,	,	PUNCT
admet-1513	851	11	k.l	k.l	PROPN
admet-1513	851	12	.	.	PROPN
admet-1513	851	13	brouwer	brouwer	PROPN
admet-1513	851	14	.	.	PUNCT
admet-1513	852	1	sandwich	sandwich	NOUN
admet-1513	852	2	-	-	PUNCT
admet-1513	852	3	cultured	cultured	ADJ
admet-1513	852	4	hepatocytes	hepatocyte	NOUN
admet-1513	852	5	:	:	PUNCT
admet-1513	852	6	an	an	DET
admet-1513	852	7	in	in	ADP
admet-1513	852	8	vitro	vitro	X
admet-1513	852	9	model	model	NOUN
admet-1513	852	10	to	to	PART
admet-1513	852	11	evaluate	evaluate	VERB
admet-1513	852	12	hepatobiliary	hepatobiliary	ADJ
admet-1513	852	13	transporter	transporter	NOUN
admet-1513	852	14	-	-	PUNCT
admet-1513	852	15	based	base	VERB
admet-1513	852	16	drug	drug	NOUN
admet-1513	852	17	interactions	interaction	NOUN
admet-1513	852	18	and	and	CCONJ
admet-1513	852	19	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	852	20	.	.	PUNCT
admet-1513	853	1	drug	drug	PROPN
admet-1513	853	2	metab	metab	PROPN
admet-1513	853	3	.	.	PUNCT
admet-1513	854	1	rev	rev	PROPN
admet-1513	854	2	.	.	PROPN
admet-1513	855	1	42	42	NUM
admet-1513	855	2	(	(	PUNCT
admet-1513	855	3	2010	2010	NUM
admet-1513	855	4	)	)	PUNCT
admet-1513	855	5	446	446	NUM
admet-1513	855	6	-	-	SYM
admet-1513	855	7	471	471	NUM
admet-1513	855	8	.	.	PUNCT
admet-1513	856	1	https://doi.org/10.3109/03602530903491881	https://doi.org/10.3109/03602530903491881	NOUN
admet-1513	856	2	.	.	PUNCT
admet-1513	857	1	[	[	X
admet-1513	857	2	68	68	NUM
admet-1513	857	3	]	]	X
admet-1513	857	4	g.	g.	NOUN
admet-1513	857	5	tuschl	tuschl	PROPN
admet-1513	857	6	,	,	PUNCT
admet-1513	857	7	j.	j.	PROPN
admet-1513	857	8	hrach	hrach	PROPN
admet-1513	857	9	,	,	PUNCT
admet-1513	857	10	y.	y.	PROPN
admet-1513	857	11	walter	walter	PROPN
admet-1513	857	12	,	,	PUNCT
admet-1513	857	13	p.g	p.g	PROPN
admet-1513	857	14	.	.	PROPN
admet-1513	857	15	hewitt	hewitt	PROPN
admet-1513	857	16	,	,	PUNCT
admet-1513	857	17	s.o	s.o	PROPN
admet-1513	857	18	.	.	PROPN
admet-1513	857	19	mueller	mueller	PROPN
admet-1513	857	20	.	.	PUNCT
admet-1513	858	1	serum	serum	NOUN
admet-1513	858	2	-	-	PUNCT
admet-1513	858	3	free	free	ADJ
admet-1513	858	4	collagen	collagen	NOUN
admet-1513	858	5	sandwich	sandwich	NOUN
admet-1513	858	6	cultures	culture	NOUN
admet-1513	858	7	of	of	ADP
admet-1513	858	8	adult	adult	NOUN
admet-1513	858	9	rat	rat	NOUN
admet-1513	858	10	hepatocytes	hepatocyte	NOUN
admet-1513	858	11	maintain	maintain	VERB
admet-1513	858	12	liver	liver	NOUN
admet-1513	858	13	-	-	PUNCT
admet-1513	858	14	like	like	ADJ
admet-1513	858	15	properties	property	NOUN
admet-1513	858	16	long	long	ADJ
admet-1513	858	17	term	term	NOUN
admet-1513	858	18	:	:	PUNCT
admet-1513	858	19	a	a	DET
admet-1513	858	20	valuable	valuable	ADJ
admet-1513	858	21	model	model	NOUN
admet-1513	858	22	for	for	ADP
admet-1513	858	23	in	in	ADP
admet-1513	858	24	vitro	vitro	X
admet-1513	858	25	toxicity	toxicity	NOUN
admet-1513	858	26	and	and	CCONJ
admet-1513	858	27	drug	drug	NOUN
admet-1513	858	28	-	-	PUNCT
admet-1513	858	29	drug	drug	NOUN
admet-1513	858	30	interaction	interaction	NOUN
admet-1513	858	31	studies	study	NOUN
admet-1513	858	32	.	.	PUNCT
admet-1513	859	1	chem	chem	NOUN
admet-1513	859	2	.	.	PUNCT
admet-1513	860	1	biol	biol	PROPN
admet-1513	860	2	.	.	PUNCT
admet-1513	861	1	interact	interact	VERB
admet-1513	861	2	.	.	PUNCT
admet-1513	862	1	181	181	NUM
admet-1513	862	2	(	(	PUNCT
admet-1513	862	3	2009	2009	NUM
admet-1513	862	4	)	)	PUNCT
admet-1513	862	5	124	124	NUM
admet-1513	862	6	-	-	SYM
admet-1513	862	7	137	137	NUM
admet-1513	862	8	.	.	PUNCT
admet-1513	863	1	https://doi.org/10.1016/j.cbi.2009.05.015	https://doi.org/10.1016/j.cbi.2009.05.015	VERB
admet-1513	863	2	.	.	PUNCT
admet-1513	864	1	[	[	X
admet-1513	864	2	69	69	NUM
admet-1513	864	3	]	]	X
admet-1513	864	4	g.	g.	PROPN
admet-1513	864	5	camenisch	camenisch	PROPN
admet-1513	864	6	,	,	PUNCT
admet-1513	864	7	k.	k.	PROPN
admet-1513	864	8	umehara	umehara	PROPN
admet-1513	864	9	.	.	PUNCT
admet-1513	865	1	predicting	predict	VERB
admet-1513	865	2	human	human	ADJ
admet-1513	865	3	hepatic	hepatic	ADJ
admet-1513	865	4	clearance	clearance	NOUN
admet-1513	865	5	from	from	ADP
admet-1513	865	6	in	in	ADP
admet-1513	865	7	vitro	vitro	X
admet-1513	865	8	drug	drug	NOUN
admet-1513	865	9	metabolism	metabolism	NOUN
admet-1513	865	10	and	and	CCONJ
admet-1513	865	11	transport	transport	NOUN
admet-1513	865	12	data	datum	NOUN
admet-1513	865	13	:	:	PUNCT
admet-1513	865	14	a	a	DET
admet-1513	865	15	scientific	scientific	ADJ
admet-1513	865	16	and	and	CCONJ
admet-1513	865	17	pharmaceutical	pharmaceutical	NOUN
admet-1513	865	18	perspective	perspective	NOUN
admet-1513	865	19	for	for	ADP
admet-1513	865	20	assessing	assess	VERB
admet-1513	865	21	drug	drug	NOUN
admet-1513	865	22	-	-	PUNCT
admet-1513	865	23	drug	drug	NOUN
admet-1513	865	24	interactions	interaction	NOUN
admet-1513	865	25	.	.	PUNCT
admet-1513	866	1	biopharm	biopharm	NOUN
admet-1513	866	2	.	.	PUNCT
admet-1513	867	1	drug	drug	PROPN
admet-1513	867	2	dispos	dispos	PROPN
admet-1513	867	3	.	.	PUNCT
admet-1513	868	1	33	33	NUM
admet-1513	868	2	(	(	PUNCT
admet-1513	868	3	2012	2012	NUM
admet-1513	868	4	)	)	PUNCT
admet-1513	868	5	179	179	NUM
admet-1513	868	6	-	-	SYM
admet-1513	868	7	194	194	NUM
admet-1513	868	8	.	.	PUNCT
admet-1513	869	1	https://doi.org/10.1002/bdd.1784	https://doi.org/10.1002/bdd.1784	NOUN
admet-1513	869	2	.	.	PUNCT
admet-1513	870	1	[	[	X
admet-1513	870	2	70	70	NUM
admet-1513	870	3	]	]	X
admet-1513	870	4	u.	u.	NOUN
admet-1513	870	5	christians	christians	PROPN
admet-1513	870	6	,	,	PUNCT
admet-1513	870	7	v.	v.	ADP
admet-1513	870	8	schmitz	schmitz	PROPN
admet-1513	870	9	,	,	PUNCT
admet-1513	870	10	m.	m.	NOUN
admet-1513	870	11	haschke	haschke	PROPN
admet-1513	870	12	.	.	PUNCT
admet-1513	871	1	functional	functional	ADJ
admet-1513	871	2	interactions	interaction	NOUN
admet-1513	871	3	between	between	ADP
admet-1513	871	4	p	p	NOUN
admet-1513	871	5	-	-	PUNCT
admet-1513	871	6	glycoprotein	glycoprotein	NOUN
admet-1513	871	7	and	and	CCONJ
admet-1513	871	8	cyp3a	cyp3a	NOUN
admet-1513	871	9	in	in	ADP
admet-1513	871	10	drug	drug	NOUN
admet-1513	871	11	metabolism	metabolism	NOUN
admet-1513	871	12	.	.	PUNCT
admet-1513	872	1	expert	expert	NOUN
admet-1513	872	2	opin	opin	NOUN
admet-1513	872	3	.	.	PUNCT
admet-1513	873	1	drug	drug	NOUN
admet-1513	873	2	metab	metab	NOUN
admet-1513	873	3	.	.	PUNCT
admet-1513	874	1	toxicol	toxicol	PROPN
admet-1513	874	2	.	.	PROPN
admet-1513	874	3	1	1	NUM
admet-1513	874	4	(	(	PUNCT
admet-1513	874	5	2005	2005	NUM
admet-1513	874	6	)	)	PUNCT
admet-1513	874	7	641	641	NUM
admet-1513	874	8	-	-	SYM
admet-1513	874	9	654	654	NUM
admet-1513	874	10	.	.	PUNCT
admet-1513	874	11	https://doi.org/10.1517/17425255.1.4.641	https://doi.org/10.1517/17425255.1.4.641	PROPN
admet-1513	874	12	.	.	PUNCT
admet-1513	875	1	[	[	X
admet-1513	875	2	71	71	NUM
admet-1513	875	3	]	]	X
admet-1513	875	4	y.	y.	PROPN
admet-1513	875	5	sai	sai	PROPN
admet-1513	875	6	.	.	PUNCT
admet-1513	876	1	biochemical	biochemical	ADJ
admet-1513	876	2	and	and	CCONJ
admet-1513	876	3	molecular	molecular	ADJ
admet-1513	876	4	pharmacological	pharmacological	ADJ
admet-1513	876	5	aspects	aspect	NOUN
admet-1513	876	6	of	of	ADP
admet-1513	876	7	transporters	transporter	NOUN
admet-1513	876	8	as	as	ADP
admet-1513	876	9	determinants	determinant	NOUN
admet-1513	876	10	of	of	ADP
admet-1513	876	11	drug	drug	NOUN
admet-1513	876	12	disposition	disposition	NOUN
admet-1513	876	13	.	.	PUNCT
admet-1513	877	1	drug	drug	NOUN
admet-1513	877	2	metab	metab	PROPN
admet-1513	877	3	.	.	PUNCT
admet-1513	878	1	pharmacokinet	pharmacokinet	NOUN
admet-1513	878	2	.	.	PUNCT
admet-1513	879	1	20	20	NUM
admet-1513	879	2	(	(	PUNCT
admet-1513	879	3	2005	2005	NUM
admet-1513	879	4	)	)	PUNCT
admet-1513	879	5	91	91	NUM
admet-1513	879	6	-	-	SYM
admet-1513	879	7	99	99	NUM
admet-1513	879	8	.	.	PUNCT
admet-1513	880	1	https://doi.org/10.2133/dmpk.20.91	https://doi.org/10.2133/dmpk.20.91	NOUN
admet-1513	880	2	.	.	PUNCT
admet-1513	881	1	[	[	X
admet-1513	881	2	72	72	NUM
admet-1513	881	3	]	]	PUNCT
admet-1513	881	4	j.	j.	PROPN
admet-1513	881	5	zhang	zhang	PROPN
admet-1513	881	6	,	,	PUNCT
admet-1513	881	7	u.	u.	PROPN
admet-1513	881	8	doshi	doshi	PROPN
admet-1513	881	9	,	,	PUNCT
admet-1513	881	10	a.	a.	PROPN
admet-1513	881	11	suzuki	suzuki	PROPN
admet-1513	881	12	,	,	PUNCT
admet-1513	881	13	c.w	c.w	PROPN
admet-1513	881	14	.	.	PROPN
admet-1513	881	15	chang	chang	PROPN
admet-1513	881	16	,	,	PUNCT
admet-1513	881	17	j.	j.	PROPN
admet-1513	881	18	borlak	borlak	PROPN
admet-1513	881	19	,	,	PUNCT
admet-1513	881	20	a.p	a.p	PROPN
admet-1513	881	21	.	.	PROPN
admet-1513	881	22	li	li	PROPN
admet-1513	881	23	,	,	PUNCT
admet-1513	881	24	w.	w.	PROPN
admet-1513	881	25	tong	tong	PROPN
admet-1513	881	26	.	.	PUNCT
admet-1513	882	1	evaluation	evaluation	NOUN
admet-1513	882	2	of	of	ADP
admet-1513	882	3	multiple	multiple	ADJ
admet-1513	882	4	mechanism	mechanism	NOUN
admet-1513	882	5	-	-	PUNCT
admet-1513	882	6	based	base	VERB
admet-1513	882	7	toxicity	toxicity	NOUN
admet-1513	882	8	endpoints	endpoint	NOUN
admet-1513	882	9	in	in	ADP
admet-1513	882	10	primary	primary	ADJ
admet-1513	882	11	cultured	cultured	ADJ
admet-1513	882	12	human	human	ADJ
admet-1513	882	13	hepatocytes	hepatocyte	NOUN
admet-1513	882	14	for	for	ADP
admet-1513	882	15	the	the	DET
admet-1513	882	16	identification	identification	NOUN
admet-1513	882	17	of	of	ADP
admet-1513	882	18	drugs	drug	NOUN
admet-1513	882	19	with	with	ADP
admet-1513	882	20	clinical	clinical	ADJ
admet-1513	882	21	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	882	22	:	:	PUNCT
admet-1513	882	23	results	result	NOUN
admet-1513	882	24	from	from	ADP
admet-1513	882	25	152	152	NUM
admet-1513	882	26	marketed	market	VERB
admet-1513	882	27	drugs	drug	NOUN
admet-1513	882	28	with	with	ADP
admet-1513	882	29	known	know	VERB
admet-1513	882	30	liver	liver	NOUN
admet-1513	882	31	injury	injury	NOUN
admet-1513	882	32	profiles	profile	NOUN
admet-1513	882	33	.	.	PUNCT
admet-1513	883	1	chem	chem	NOUN
admet-1513	883	2	.	.	PUNCT
admet-1513	884	1	biol	biol	PROPN
admet-1513	884	2	.	.	PUNCT
admet-1513	885	1	interact	interact	VERB
admet-1513	885	2	.	.	PUNCT
admet-1513	886	1	255	255	NUM
admet-1513	886	2	(	(	PUNCT
admet-1513	886	3	2016	2016	NUM
admet-1513	886	4	)	)	PUNCT
admet-1513	886	5	3	3	NUM
admet-1513	886	6	-	-	SYM
admet-1513	886	7	11	11	NUM
admet-1513	886	8	.	.	PUNCT
admet-1513	887	1	https://doi.org/10.1016/j.cbi.2015.11.008	https://doi.org/10.1016/j.cbi.2015.11.008	NOUN
admet-1513	887	2	.	.	PUNCT
admet-1513	887	3	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	887	4	https://doi.org/10.1124/dmd.104.000026	https://doi.org/10.1124/dmd.104.000026	VERB
admet-1513	887	5	https://doi.org/10.1124/dmd.31.9.1093	https://doi.org/10.1124/dmd.31.9.1093	NOUN
admet-1513	887	6	https://doi.org/10.1016/s0009-2797(97)00072-0	https://doi.org/10.1016/s0009-2797(97)00072-0	NOUN
admet-1513	887	7	https://doi.org/10.1016/s0009-2797(97)00072-0	https://doi.org/10.1016/s0009-2797(97)00072-0	NOUN
admet-1513	887	8	https://doi.org/10.2174/1389200043335414	https://doi.org/10.2174/1389200043335414	NUM
admet-1513	887	9	https://doi.org/10.2174/1389200043335414	https://doi.org/10.2174/1389200043335414	NOUN
admet-1513	887	10	https://doi.org/10.1016/j.cbi.2006.10.013	https://doi.org/10.1016/j.cbi.2006.10.013	VERB
admet-1513	888	1	https://doi.org/10.1016/s1084952102001350	https://doi.org/10.1016/s1084952102001350	PROPN
admet-1513	888	2	https://doi.org/10.1016/s1084952102001350	https://doi.org/10.1016/s1084952102001350	PROPN
admet-1513	888	3	https://doi.org/10.1517/17425255.2013.773973	https://doi.org/10.1517/17425255.2013.773973	VERB
admet-1513	888	4	https://doi.org/10.1517/17425255.2013.773973	https://doi.org/10.1517/17425255.2013.773973	VERB
admet-1513	889	1	https://doi.org/10.3109/03602530903491881	https://doi.org/10.3109/03602530903491881	ADV
admet-1513	889	2	https://doi.org/10.1016/j.cbi.2009.05.015	https://doi.org/10.1016/j.cbi.2009.05.015	X
admet-1513	889	3	https://doi.org/10.1016/j.cbi.2009.05.015	https://doi.org/10.1016/j.cbi.2009.05.015	ADV
admet-1513	889	4	https://doi.org/10.1002/bdd.1784	https://doi.org/10.1002/bdd.1784	NOUN
admet-1513	889	5	https://doi.org/10.1517/17425255.1.4.641	https://doi.org/10.1517/17425255.1.4.641	VERB
admet-1513	889	6	https://doi.org/10.1517/17425255.1.4.641	https://doi.org/10.1517/17425255.1.4.641	VERB
admet-1513	889	7	https://doi.org/10.2133/dmpk.20.91	https://doi.org/10.2133/dmpk.20.91	NOUN
admet-1513	889	8	https://doi.org/10.1016/j.cbi.2015.11.008	https://doi.org/10.1016/j.cbi.2015.11.008	NOUN
admet-1513	889	9	venkatesh	venkatesh	NOUN
admet-1513	889	10	chunduri	chunduri	NOUN
admet-1513	889	11	and	and	CCONJ
admet-1513	889	12	srinivas	srinivas	PROPN
admet-1513	889	13	maddi	maddi	PROPN
admet-1513	889	14	admet	admet	PROPN
admet-1513	889	15	&	&	CCONJ
admet-1513	889	16	dmpk	dmpk	PROPN
admet-1513	889	17	11(1	11(1	NUM
admet-1513	889	18	)	)	PUNCT
admet-1513	889	19	(	(	PUNCT
admet-1513	889	20	2023	2023	NUM
admet-1513	889	21	)	)	PUNCT
admet-1513	889	22	1	1	NUM
admet-1513	889	23	-	-	SYM
admet-1513	889	24	32	32	NUM
admet-1513	889	25	22	22	NUM
admet-1513	890	1	[	[	X
admet-1513	890	2	73	73	NUM
admet-1513	890	3	]	]	X
admet-1513	890	4	n.j	n.j	PROPN
admet-1513	890	5	.	.	PROPN
admet-1513	890	6	hewitt	hewitt	PROPN
admet-1513	890	7	,	,	PUNCT
admet-1513	890	8	m.j	m.j	PROPN
admet-1513	890	9	.	.	PROPN
admet-1513	890	10	lechón	lechón	PROPN
admet-1513	890	11	,	,	PUNCT
admet-1513	890	12	j.b	j.b	PROPN
admet-1513	890	13	.	.	PROPN
admet-1513	890	14	houston	houston	PROPN
admet-1513	890	15	,	,	PUNCT
admet-1513	890	16	d.	d.	PROPN
admet-1513	890	17	hallifax	hallifax	PROPN
admet-1513	890	18	,	,	PUNCT
admet-1513	890	19	h.s	h.s	PROPN
admet-1513	890	20	.	.	PROPN
admet-1513	890	21	brown	brown	PROPN
admet-1513	890	22	,	,	PUNCT
admet-1513	890	23	p.	p.	NOUN
admet-1513	890	24	maurel	maurel	PROPN
admet-1513	890	25	,	,	PUNCT
admet-1513	890	26	j.g	j.g	PROPN
admet-1513	890	27	.	.	PROPN
admet-1513	890	28	kenna	kenna	PROPN
admet-1513	890	29	,	,	PUNCT
admet-1513	890	30	l.	l.	PROPN
admet-1513	890	31	gustavsson	gustavsson	PROPN
admet-1513	890	32	,	,	PUNCT
admet-1513	890	33	c.	c.	PROPN
admet-1513	890	34	lohmann	lohmann	PROPN
admet-1513	890	35	,	,	PUNCT
admet-1513	890	36	c.	c.	PROPN
admet-1513	890	37	skonberg	skonberg	PROPN
admet-1513	890	38	,	,	PUNCT
admet-1513	890	39	a.	a.	NOUN
admet-1513	890	40	guillouzo	guillouzo	PROPN
admet-1513	890	41	,	,	PUNCT
admet-1513	890	42	g.	g.	PROPN
admet-1513	890	43	tuschl	tuschl	PROPN
admet-1513	890	44	,	,	PUNCT
admet-1513	890	45	a.p	a.p	PROPN
admet-1513	890	46	.	.	PROPN
admet-1513	890	47	li	li	PROPN
admet-1513	890	48	,	,	PUNCT
admet-1513	890	49	e.	e.	PROPN
admet-1513	890	50	lecluyse	lecluyse	PROPN
admet-1513	890	51	,	,	PUNCT
admet-1513	890	52	g.m	g.m	PROPN
admet-1513	890	53	.	.	PROPN
admet-1513	890	54	groothuis	groothuis	PROPN
admet-1513	890	55	,	,	PUNCT
admet-1513	890	56	j.g	j.g	PROPN
admet-1513	890	57	.	.	PROPN
admet-1513	890	58	hengstler	hengstler	PROPN
admet-1513	890	59	.	.	PUNCT
admet-1513	891	1	primary	primary	ADJ
admet-1513	891	2	hepatocytes	hepatocyte	NOUN
admet-1513	891	3	:	:	PUNCT
admet-1513	891	4	current	current	ADJ
admet-1513	891	5	understanding	understanding	NOUN
admet-1513	891	6	of	of	ADP
admet-1513	891	7	the	the	DET
admet-1513	891	8	regulation	regulation	NOUN
admet-1513	891	9	of	of	ADP
admet-1513	891	10	metabolic	metabolic	NOUN
admet-1513	891	11	enzymes	enzyme	NOUN
admet-1513	891	12	and	and	CCONJ
admet-1513	891	13	transporter	transporter	NOUN
admet-1513	891	14	proteins	protein	NOUN
admet-1513	891	15	,	,	PUNCT
admet-1513	891	16	and	and	CCONJ
admet-1513	891	17	pharmaceutical	pharmaceutical	NOUN
admet-1513	891	18	practice	practice	NOUN
admet-1513	891	19	for	for	ADP
admet-1513	891	20	the	the	DET
admet-1513	891	21	use	use	NOUN
admet-1513	891	22	of	of	ADP
admet-1513	891	23	hepatocytes	hepatocyte	NOUN
admet-1513	891	24	in	in	ADP
admet-1513	891	25	metabolism	metabolism	NOUN
admet-1513	891	26	,	,	PUNCT
admet-1513	891	27	enzyme	enzyme	NOUN
admet-1513	891	28	induction	induction	NOUN
admet-1513	891	29	,	,	PUNCT
admet-1513	891	30	transporter	transporter	NOUN
admet-1513	891	31	,	,	PUNCT
admet-1513	891	32	clearance	clearance	NOUN
admet-1513	891	33	,	,	PUNCT
admet-1513	891	34	and	and	CCONJ
admet-1513	891	35	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	891	36	studies	study	NOUN
admet-1513	891	37	.	.	PUNCT
admet-1513	892	1	drug	drug	NOUN
admet-1513	892	2	metab	metab	PROPN
admet-1513	892	3	.	.	PUNCT
admet-1513	893	1	rev	rev	PROPN
admet-1513	893	2	.	.	PROPN
admet-1513	893	3	39	39	NUM
admet-1513	893	4	(	(	PUNCT
admet-1513	893	5	2007	2007	NUM
admet-1513	893	6	)	)	PUNCT
admet-1513	893	7	159	159	NUM
admet-1513	893	8	-	-	SYM
admet-1513	893	9	234	234	NUM
admet-1513	893	10	.	.	PUNCT
admet-1513	894	1	https://doi.org/10.1080/03602530601093489	https://doi.org/10.1080/03602530601093489	NOUN
admet-1513	894	2	.	.	PUNCT
admet-1513	895	1	[	[	X
admet-1513	895	2	74	74	NUM
admet-1513	895	3	]	]	X
admet-1513	895	4	m.t	m.t	PROPN
admet-1513	895	5	.	.	PROPN
admet-1513	895	6	donato	donato	PROPN
admet-1513	895	7	,	,	PUNCT
admet-1513	895	8	l.	l.	PROPN
admet-1513	895	9	tolosa	tolosa	PROPN
admet-1513	895	10	,	,	PUNCT
admet-1513	895	11	m.j	m.j	PROPN
admet-1513	895	12	.	.	PROPN
admet-1513	895	13	gómez	gómez	PROPN
admet-1513	895	14	-	-	PUNCT
admet-1513	895	15	lechón	lechón	PROPN
admet-1513	895	16	.	.	PUNCT
admet-1513	896	1	culture	culture	NOUN
admet-1513	896	2	and	and	CCONJ
admet-1513	896	3	functional	functional	ADJ
admet-1513	896	4	characterization	characterization	NOUN
admet-1513	896	5	of	of	ADP
admet-1513	896	6	human	human	ADJ
admet-1513	896	7	hepatoma	hepatoma	NOUN
admet-1513	896	8	hepg2	hepg2	PUNCT
admet-1513	897	1	cells	cell	NOUN
admet-1513	897	2	.	.	PUNCT
admet-1513	898	1	methods	method	NOUN
admet-1513	898	2	mol	mol	PROPN
admet-1513	898	3	.	.	PUNCT
admet-1513	899	1	biol	biol	PROPN
admet-1513	899	2	.	.	PUNCT
admet-1513	900	1	1250	1250	NUM
admet-1513	900	2	(	(	PUNCT
admet-1513	900	3	2015	2015	NUM
admet-1513	900	4	)	)	PUNCT
admet-1513	900	5	77	77	NUM
admet-1513	900	6	-	-	SYM
admet-1513	900	7	93	93	NUM
admet-1513	900	8	.	.	PUNCT
admet-1513	901	1	https://doi.org/10.1007/978-1-49392074-7_5	https://doi.org/10.1007/978-1-49392074-7_5	INTJ
admet-1513	901	2	.	.	PUNCT
admet-1513	902	1	[	[	X
admet-1513	902	2	75	75	NUM
admet-1513	902	3	]	]	PUNCT
admet-1513	902	4	c.	c.	PROPN
admet-1513	902	5	rodríguez	rodríguez	PROPN
admet-1513	902	6	-	-	PUNCT
admet-1513	902	7	antona	antona	NOUN
admet-1513	902	8	,	,	PUNCT
admet-1513	902	9	m.t	m.t	PROPN
admet-1513	902	10	.	.	PROPN
admet-1513	902	11	donato	donato	PROPN
admet-1513	902	12	,	,	PUNCT
admet-1513	902	13	a.	a.	NOUN
admet-1513	902	14	boobis	boobis	NOUN
admet-1513	902	15	,	,	PUNCT
admet-1513	902	16	r.j	r.j	PROPN
admet-1513	902	17	.	.	PROPN
admet-1513	902	18	edwards	edwards	PROPN
admet-1513	902	19	,	,	PUNCT
admet-1513	902	20	p.s	p.s	PROPN
admet-1513	902	21	.	.	PROPN
admet-1513	902	22	watts	watts	PROPN
admet-1513	902	23	,	,	PUNCT
admet-1513	902	24	j.v	j.v	PROPN
admet-1513	902	25	.	.	PROPN
admet-1513	902	26	castell	castell	PROPN
admet-1513	902	27	,	,	PUNCT
admet-1513	902	28	m.j	m.j	PROPN
admet-1513	902	29	.	.	PROPN
admet-1513	902	30	gómezlechón	gómezlechón	PROPN
admet-1513	902	31	.	.	PUNCT
admet-1513	903	1	cytochrome	cytochrome	NOUN
admet-1513	903	2	p450	p450	NUM
admet-1513	903	3	expression	expression	NOUN
admet-1513	903	4	in	in	ADP
admet-1513	903	5	human	human	ADJ
admet-1513	903	6	hepatocytes	hepatocyte	NOUN
admet-1513	903	7	and	and	CCONJ
admet-1513	903	8	hepatoma	hepatoma	VERB
admet-1513	903	9	cell	cell	NOUN
admet-1513	903	10	lines	line	NOUN
admet-1513	903	11	:	:	PUNCT
admet-1513	903	12	molecular	molecular	ADJ
admet-1513	903	13	mechanisms	mechanism	NOUN
admet-1513	903	14	that	that	PRON
admet-1513	903	15	determine	determine	VERB
admet-1513	903	16	lower	low	ADJ
admet-1513	903	17	expression	expression	NOUN
admet-1513	903	18	in	in	ADP
admet-1513	903	19	cultured	cultured	ADJ
admet-1513	903	20	cells	cell	NOUN
admet-1513	903	21	.	.	PUNCT
admet-1513	904	1	xenobiotica	xenobiotica	PROPN
admet-1513	904	2	32	32	NUM
admet-1513	904	3	(	(	PUNCT
admet-1513	904	4	2002	2002	NUM
admet-1513	904	5	)	)	PUNCT
admet-1513	904	6	505	505	NUM
admet-1513	904	7	-	-	SYM
admet-1513	904	8	520	520	NUM
admet-1513	904	9	.	.	PUNCT
admet-1513	905	1	https://doi.org/10.1080/00498250210128675	https://doi.org/10.1080/00498250210128675	NUM
admet-1513	905	2	.	.	PUNCT
admet-1513	906	1	[	[	X
admet-1513	906	2	76	76	NUM
admet-1513	906	3	]	]	X
admet-1513	906	4	m.	m.	NOUN
admet-1513	906	5	kawamoto	kawamoto	NOUN
admet-1513	906	6	,	,	PUNCT
admet-1513	906	7	t.	t.	PROPN
admet-1513	906	8	yamaji	yamaji	PROPN
admet-1513	906	9	,	,	PUNCT
admet-1513	906	10	k.	k.	PROPN
admet-1513	906	11	saito	saito	PROPN
admet-1513	906	12	,	,	PUNCT
admet-1513	906	13	y.	y.	PROPN
admet-1513	906	14	shirasago	shirasago	PROPN
admet-1513	906	15	,	,	PUNCT
admet-1513	906	16	k.	k.	PROPN
admet-1513	906	17	satomura	satomura	PROPN
admet-1513	906	18	,	,	PUNCT
admet-1513	906	19	t.	t.	PROPN
admet-1513	906	20	endo	endo	PROPN
admet-1513	906	21	,	,	PUNCT
admet-1513	906	22	m.	m.	NOUN
admet-1513	906	23	fukasawa	fukasawa	PROPN
admet-1513	906	24	,	,	PUNCT
admet-1513	906	25	k.	k.	PROPN
admet-1513	906	26	hanada	hanada	PROPN
admet-1513	906	27	,	,	PUNCT
admet-1513	906	28	n.	n.	PROPN
admet-1513	906	29	osada	osada	PROPN
admet-1513	906	30	.	.	PUNCT
admet-1513	907	1	identification	identification	NOUN
admet-1513	907	2	of	of	ADP
admet-1513	907	3	characteristic	characteristic	ADJ
admet-1513	907	4	genomic	genomic	NOUN
admet-1513	907	5	markers	marker	NOUN
admet-1513	907	6	in	in	ADP
admet-1513	907	7	human	human	ADJ
admet-1513	907	8	hepatoma	hepatoma	NOUN
admet-1513	907	9	huh-7	huh-7	ADP
admet-1513	907	10	and	and	CCONJ
admet-1513	907	11	huh7.5.1	huh7.5.1	PROPN
admet-1513	907	12	-	-	PUNCT
admet-1513	907	13	8	8	NUM
admet-1513	907	14	cell	cell	NOUN
admet-1513	907	15	lines	line	NOUN
admet-1513	907	16	.	.	PUNCT
admet-1513	908	1	front	front	ADJ
admet-1513	908	2	.	.	PUNCT
admet-1513	909	1	genet	genet	NOUN
admet-1513	909	2	.	.	PUNCT
admet-1513	910	1	11	11	NUM
admet-1513	910	2	(	(	PUNCT
admet-1513	910	3	2020	2020	NUM
admet-1513	910	4	)	)	PUNCT
admet-1513	910	5	546106	546106	NUM
admet-1513	910	6	.	.	PUNCT
admet-1513	911	1	https://doi.org/10.3389/fgene.2020.546106	https://doi.org/10.3389/fgene.2020.546106	NOUN
admet-1513	911	2	.	.	PUNCT
admet-1513	912	1	[	[	X
admet-1513	912	2	77	77	NUM
admet-1513	912	3	]	]	X
admet-1513	912	4	s.	s.	PROPN
admet-1513	912	5	choi	choi	PROPN
admet-1513	912	6	,	,	PUNCT
admet-1513	912	7	b.	b.	PROPN
admet-1513	912	8	sainz	sainz	PROPN
admet-1513	912	9	,	,	PUNCT
admet-1513	912	10	p.	p.	PROPN
admet-1513	912	11	corcoran	corcoran	NOUN
admet-1513	912	12	,	,	PUNCT
admet-1513	912	13	s.	s.	PROPN
admet-1513	912	14	uprichard	uprichard	PROPN
admet-1513	912	15	,	,	PUNCT
admet-1513	912	16	h.	h.	PROPN
admet-1513	912	17	jeong	jeong	PROPN
admet-1513	912	18	.	.	PUNCT
admet-1513	912	19	characterization	characterization	NOUN
admet-1513	912	20	of	of	ADP
admet-1513	912	21	increased	increase	VERB
admet-1513	912	22	drug	drug	NOUN
admet-1513	912	23	metabolism	metabolism	NOUN
admet-1513	912	24	activity	activity	NOUN
admet-1513	912	25	in	in	ADP
admet-1513	912	26	dimethyl	dimethyl	NOUN
admet-1513	912	27	sulfoxide	sulfoxide	NOUN
admet-1513	912	28	(	(	PUNCT
admet-1513	912	29	dmso)-treated	dmso)-treate	VERB
admet-1513	912	30	huh7	huh7	NOUN
admet-1513	912	31	hepatoma	hepatoma	NOUN
admet-1513	912	32	cells	cell	NOUN
admet-1513	912	33	.	.	PUNCT
admet-1513	913	1	xenobiotica	xenobiotica	PROPN
admet-1513	913	2	39	39	NUM
admet-1513	913	3	(	(	PUNCT
admet-1513	913	4	2009	2009	NUM
admet-1513	913	5	)	)	PUNCT
admet-1513	913	6	205	205	NUM
admet-1513	913	7	-	-	SYM
admet-1513	913	8	217	217	NUM
admet-1513	913	9	.	.	PUNCT
admet-1513	914	1	https://doi.org/10.1080/00498250802613620	https://doi.org/10.1080/00498250802613620	X
admet-1513	914	2	.	.	PUNCT
admet-1513	915	1	[	[	X
admet-1513	915	2	78	78	NUM
admet-1513	915	3	]	]	PUNCT
admet-1513	915	4	j.	j.	PROPN
admet-1513	915	5	lin	lin	PROPN
admet-1513	915	6	,	,	PUNCT
admet-1513	915	7	l.	l.	PROPN
admet-1513	915	8	schyschka	schyschka	PROPN
admet-1513	915	9	,	,	PUNCT
admet-1513	915	10	r.	r.	PROPN
admet-1513	915	11	mühl	mühl	PROPN
admet-1513	915	12	-	-	PUNCT
admet-1513	915	13	benninghaus	benninghaus	PROPN
admet-1513	915	14	,	,	PUNCT
admet-1513	915	15	j.	j.	PROPN
admet-1513	915	16	neumann	neumann	PROPN
admet-1513	915	17	,	,	PUNCT
admet-1513	915	18	l.	l.	PROPN
admet-1513	915	19	hao	hao	PROPN
admet-1513	915	20	,	,	PUNCT
admet-1513	915	21	n.	n.	PROPN
admet-1513	915	22	nussler	nussler	PROPN
admet-1513	915	23	,	,	PUNCT
admet-1513	915	24	s.	s.	PROPN
admet-1513	915	25	dooley	dooley	PROPN
admet-1513	915	26	,	,	PUNCT
admet-1513	915	27	l.	l.	PROPN
admet-1513	915	28	liu	liu	PROPN
admet-1513	915	29	,	,	PUNCT
admet-1513	915	30	u.	u.	PROPN
admet-1513	915	31	stöckle	stöckle	PROPN
admet-1513	915	32	,	,	PUNCT
admet-1513	915	33	a.k	a.k	PROPN
admet-1513	915	34	.	.	PROPN
admet-1513	915	35	nussler	nussler	PROPN
admet-1513	915	36	,	,	PUNCT
admet-1513	915	37	s.	s.	PROPN
admet-1513	915	38	ehnert	ehnert	PROPN
admet-1513	915	39	.	.	PUNCT
admet-1513	916	1	comparative	comparative	ADJ
admet-1513	916	2	analysis	analysis	NOUN
admet-1513	916	3	of	of	ADP
admet-1513	916	4	phase	phase	NOUN
admet-1513	916	5	i	i	PRON
admet-1513	916	6	and	and	CCONJ
admet-1513	916	7	ii	ii	NOUN
admet-1513	916	8	enzyme	enzyme	NOUN
admet-1513	916	9	activities	activity	NOUN
admet-1513	916	10	in	in	ADP
admet-1513	916	11	5	5	NUM
admet-1513	916	12	hepatic	hepatic	ADJ
admet-1513	916	13	cell	cell	NOUN
admet-1513	916	14	lines	line	NOUN
admet-1513	916	15	identifies	identify	VERB
admet-1513	916	16	huh-7	huh-7	PUNCT
admet-1513	916	17	and	and	CCONJ
admet-1513	916	18	hcc	hcc	PROPN
admet-1513	916	19	-	-	PUNCT
admet-1513	916	20	t	t	NOUN
admet-1513	916	21	cells	cell	NOUN
admet-1513	916	22	with	with	ADP
admet-1513	916	23	the	the	DET
admet-1513	916	24	highest	high	ADJ
admet-1513	916	25	potential	potential	NOUN
admet-1513	916	26	to	to	PART
admet-1513	916	27	study	study	VERB
admet-1513	916	28	drug	drug	NOUN
admet-1513	916	29	metabolism	metabolism	NOUN
admet-1513	916	30	.	.	PUNCT
admet-1513	917	1	arch	arch	NOUN
admet-1513	917	2	.	.	PUNCT
admet-1513	918	1	toxicol	toxicol	PROPN
admet-1513	918	2	.	.	PUNCT
admet-1513	919	1	86	86	NUM
admet-1513	919	2	(	(	PUNCT
admet-1513	919	3	2012	2012	NUM
admet-1513	919	4	)	)	PUNCT
admet-1513	919	5	87	87	NUM
admet-1513	919	6	-	-	SYM
admet-1513	919	7	95	95	NUM
admet-1513	919	8	.	.	PUNCT
admet-1513	920	1	https://doi.org/10.1007/s00204-011-0733-y	https://doi.org/10.1007/s00204-011-0733-y	NOUN
admet-1513	920	2	.	.	PUNCT
admet-1513	921	1	[	[	X
admet-1513	921	2	79	79	NUM
admet-1513	921	3	]	]	X
admet-1513	921	4	m.j	m.j	PROPN
admet-1513	921	5	.	.	PROPN
admet-1513	921	6	marion	marion	PROPN
admet-1513	921	7	,	,	PUNCT
admet-1513	921	8	o.	o.	NOUN
admet-1513	921	9	hantz	hantz	NOUN
admet-1513	921	10	,	,	PUNCT
admet-1513	921	11	d.	d.	PROPN
admet-1513	921	12	durantel	durantel	PROPN
admet-1513	921	13	.	.	PUNCT
admet-1513	922	1	the	the	DET
admet-1513	922	2	heparg	heparg	PROPN
admet-1513	922	3	cell	cell	NOUN
admet-1513	922	4	line	line	NOUN
admet-1513	922	5	:	:	PUNCT
admet-1513	922	6	biological	biological	ADJ
admet-1513	922	7	properties	property	NOUN
admet-1513	922	8	and	and	CCONJ
admet-1513	922	9	relevance	relevance	NOUN
admet-1513	922	10	as	as	ADP
admet-1513	922	11	a	a	DET
admet-1513	922	12	tool	tool	NOUN
admet-1513	922	13	for	for	ADP
admet-1513	922	14	cell	cell	NOUN
admet-1513	922	15	biology	biology	NOUN
admet-1513	922	16	,	,	PUNCT
admet-1513	922	17	drug	drug	NOUN
admet-1513	922	18	metabolism	metabolism	NOUN
admet-1513	922	19	,	,	PUNCT
admet-1513	922	20	and	and	CCONJ
admet-1513	922	21	virology	virology	NOUN
admet-1513	922	22	studies	study	NOUN
admet-1513	922	23	.	.	PUNCT
admet-1513	923	1	methods	methods	PROPN
admet-1513	923	2	mol	mol	PROPN
admet-1513	923	3	.	.	PUNCT
admet-1513	924	1	biol	biol	PROPN
admet-1513	924	2	.	.	PUNCT
admet-1513	925	1	640	640	NUM
admet-1513	925	2	(	(	PUNCT
admet-1513	925	3	2010	2010	NUM
admet-1513	925	4	)	)	PUNCT
admet-1513	925	5	261	261	NUM
admet-1513	925	6	-	-	SYM
admet-1513	925	7	272	272	NUM
admet-1513	925	8	.	.	PUNCT
admet-1513	926	1	https://doi.org/10.1007/978-1-60761-688-7_13	https://doi.org/10.1007/978-1-60761-688-7_13	NOUN
admet-1513	926	2	.	.	PUNCT
admet-1513	927	1	[	[	X
admet-1513	927	2	80	80	NUM
admet-1513	927	3	]	]	X
admet-1513	927	4	l.	l.	PROPN
admet-1513	927	5	kuna	kuna	PROPN
admet-1513	927	6	,	,	PUNCT
admet-1513	927	7	i.	i.	PROPN
admet-1513	927	8	bozic	bozic	PROPN
admet-1513	927	9	,	,	PUNCT
admet-1513	927	10	t.	t.	PROPN
admet-1513	927	11	kizivat	kizivat	PROPN
admet-1513	927	12	,	,	PUNCT
admet-1513	927	13	k.	k.	PROPN
admet-1513	927	14	bojanic	bojanic	PROPN
admet-1513	927	15	,	,	PUNCT
admet-1513	927	16	m.	m.	NOUN
admet-1513	927	17	mrso	mrso	PROPN
admet-1513	927	18	,	,	PUNCT
admet-1513	927	19	e.	e.	PROPN
admet-1513	927	20	kralj	kralj	PROPN
admet-1513	927	21	,	,	PUNCT
admet-1513	927	22	r.	r.	PROPN
admet-1513	927	23	smolic	smolic	PROPN
admet-1513	927	24	,	,	PUNCT
admet-1513	927	25	g.y	g.y	PROPN
admet-1513	927	26	.	.	PUNCT
admet-1513	927	27	wu	wu	PROPN
admet-1513	927	28	,	,	PUNCT
admet-1513	927	29	m.	m.	NOUN
admet-1513	927	30	smolic	smolic	PROPN
admet-1513	927	31	.	.	PUNCT
admet-1513	928	1	models	model	NOUN
admet-1513	928	2	of	of	ADP
admet-1513	928	3	drug	drug	NOUN
admet-1513	928	4	induced	induce	VERB
admet-1513	928	5	liver	liver	NOUN
admet-1513	928	6	injury	injury	NOUN
admet-1513	928	7	(	(	PUNCT
admet-1513	928	8	dili	dili	NOUN
admet-1513	928	9	)	)	PUNCT
admet-1513	928	10	current	current	ADJ
admet-1513	928	11	issues	issue	NOUN
admet-1513	928	12	and	and	CCONJ
admet-1513	928	13	future	future	ADJ
admet-1513	928	14	perspectives	perspective	NOUN
admet-1513	928	15	.	.	PUNCT
admet-1513	929	1	curr	curr	PROPN
admet-1513	929	2	.	.	PUNCT
admet-1513	929	3	drug	drug	PROPN
admet-1513	929	4	metab	metab	NOUN
admet-1513	929	5	.	.	PUNCT
admet-1513	930	1	19	19	NUM
admet-1513	930	2	(	(	PUNCT
admet-1513	930	3	2018	2018	NUM
admet-1513	930	4	)	)	PUNCT
admet-1513	930	5	830838	830838	NUM
admet-1513	930	6	.	.	PUNCT
admet-1513	931	1	https://doi.org/10.2174/1389200219666180523095355	https://doi.org/10.2174/1389200219666180523095355	ADJ
admet-1513	931	2	.	.	PUNCT
admet-1513	932	1	[	[	X
admet-1513	932	2	81	81	NUM
admet-1513	932	3	]	]	X
admet-1513	932	4	h.h	h.h	PROPN
admet-1513	932	5	.	.	PROPN
admet-1513	932	6	gerets	gerets	PROPN
admet-1513	932	7	,	,	PUNCT
admet-1513	932	8	k.	k.	PROPN
admet-1513	932	9	tilmant	tilmant	PROPN
admet-1513	932	10	,	,	PUNCT
admet-1513	932	11	b.	b.	PROPN
admet-1513	932	12	gerin	gerin	PROPN
admet-1513	932	13	,	,	PUNCT
admet-1513	932	14	h.	h.	PROPN
admet-1513	932	15	chanteux	chanteux	PROPN
admet-1513	932	16	,	,	PUNCT
admet-1513	932	17	b.o	b.o	PROPN
admet-1513	932	18	.	.	PROPN
admet-1513	932	19	depelchin	depelchin	PROPN
admet-1513	932	20	,	,	PUNCT
admet-1513	932	21	s.	s.	PROPN
admet-1513	932	22	dhalluin	dhalluin	PROPN
admet-1513	932	23	,	,	PUNCT
admet-1513	932	24	f.a	f.a	PROPN
admet-1513	932	25	.	.	PROPN
admet-1513	932	26	atienzar	atienzar	PROPN
admet-1513	932	27	.	.	PUNCT
admet-1513	933	1	characterization	characterization	NOUN
admet-1513	933	2	of	of	ADP
admet-1513	933	3	primary	primary	ADJ
admet-1513	933	4	human	human	ADJ
admet-1513	933	5	hepatocytes	hepatocyte	NOUN
admet-1513	933	6	,	,	PUNCT
admet-1513	933	7	hepg2	hepg2	NOUN
admet-1513	933	8	cells	cell	NOUN
admet-1513	933	9	,	,	PUNCT
admet-1513	933	10	and	and	CCONJ
admet-1513	933	11	heparg	heparg	NOUN
admet-1513	933	12	cells	cell	NOUN
admet-1513	933	13	at	at	ADP
admet-1513	933	14	the	the	DET
admet-1513	933	15	mrna	mrna	NOUN
admet-1513	933	16	level	level	NOUN
admet-1513	933	17	and	and	CCONJ
admet-1513	933	18	cyp	cyp	ADJ
admet-1513	933	19	activity	activity	NOUN
admet-1513	933	20	in	in	ADP
admet-1513	933	21	response	response	NOUN
admet-1513	933	22	to	to	ADP
admet-1513	933	23	inducers	inducer	NOUN
admet-1513	933	24	and	and	CCONJ
admet-1513	933	25	their	their	PRON
admet-1513	933	26	predictivity	predictivity	NOUN
admet-1513	933	27	for	for	ADP
admet-1513	933	28	the	the	DET
admet-1513	933	29	detection	detection	NOUN
admet-1513	933	30	of	of	ADP
admet-1513	933	31	human	human	ADJ
admet-1513	933	32	hepatotoxins	hepatotoxin	NOUN
admet-1513	933	33	.	.	PUNCT
admet-1513	934	1	cell	cell	NOUN
admet-1513	934	2	biol	biol	PROPN
admet-1513	934	3	.	.	PUNCT
admet-1513	935	1	toxicol	toxicol	PROPN
admet-1513	935	2	.	.	PUNCT
admet-1513	936	1	28	28	NUM
admet-1513	936	2	(	(	PUNCT
admet-1513	936	3	2012	2012	NUM
admet-1513	936	4	)	)	PUNCT
admet-1513	936	5	69	69	NUM
admet-1513	936	6	-	-	SYM
admet-1513	936	7	87	87	NUM
admet-1513	936	8	.	.	PUNCT
admet-1513	937	1	https://doi.org/10.1007/s10565-011-9208-4	https://doi.org/10.1007/s10565-011-9208-4	NUM
admet-1513	937	2	.	.	PUNCT
admet-1513	938	1	[	[	X
admet-1513	938	2	82	82	NUM
admet-1513	938	3	]	]	X
admet-1513	938	4	e.	e.	PROPN
admet-1513	938	5	van	van	PROPN
admet-1513	938	6	de	de	PROPN
admet-1513	938	7	steeg	steeg	PROPN
admet-1513	938	8	,	,	PUNCT
admet-1513	938	9	v.	v.	CCONJ
admet-1513	938	10	stránecký	stránecký	NOUN
admet-1513	938	11	,	,	PUNCT
admet-1513	938	12	h.	h.	PROPN
admet-1513	938	13	hartmannová	hartmannová	PROPN
admet-1513	938	14	,	,	PUNCT
admet-1513	938	15	l.	l.	PROPN
admet-1513	938	16	nosková	nosková	PROPN
admet-1513	938	17	,	,	PUNCT
admet-1513	938	18	m.	m.	NOUN
admet-1513	938	19	hřebíček	hřebíček	PROPN
admet-1513	938	20	,	,	PUNCT
admet-1513	938	21	e.	e.	PROPN
admet-1513	938	22	wagenaar	wagenaar	PROPN
admet-1513	938	23	,	,	PUNCT
admet-1513	938	24	a.	a.	PROPN
admet-1513	938	25	van	van	PROPN
admet-1513	938	26	esch	esch	PROPN
admet-1513	938	27	,	,	PUNCT
admet-1513	938	28	d.r	d.r	PROPN
admet-1513	938	29	.	.	PROPN
admet-1513	938	30	de	de	PROPN
admet-1513	938	31	waart	waart	PROPN
admet-1513	938	32	,	,	PUNCT
admet-1513	938	33	r.p	r.p	PROPN
admet-1513	938	34	.	.	PROPN
admet-1513	938	35	oude	oude	PROPN
admet-1513	938	36	elferink	elferink	PROPN
admet-1513	938	37	,	,	PUNCT
admet-1513	938	38	k.e	k.e	PROPN
admet-1513	938	39	.	.	PROPN
admet-1513	938	40	kenworthy	kenworthy	PROPN
admet-1513	938	41	,	,	PUNCT
admet-1513	938	42	e.	e.	PROPN
admet-1513	938	43	sticová	sticová	PROPN
admet-1513	938	44	,	,	PUNCT
admet-1513	938	45	m.	m.	PROPN
admet-1513	938	46	al	al	PROPN
admet-1513	938	47	-	-	PUNCT
admet-1513	938	48	edreesi	edreesi	NOUN
admet-1513	938	49	,	,	PUNCT
admet-1513	938	50	a.s	a.s	PROPN
admet-1513	938	51	.	.	PROPN
admet-1513	938	52	knisely	knisely	PROPN
admet-1513	938	53	,	,	PUNCT
admet-1513	938	54	s.	s.	PROPN
admet-1513	938	55	kmoch	kmoch	PROPN
admet-1513	938	56	,	,	PUNCT
admet-1513	938	57	m.	m.	PROPN
admet-1513	938	58	jirsa	jirsa	PROPN
admet-1513	938	59	,	,	PUNCT
admet-1513	938	60	a.h	a.h	PROPN
admet-1513	938	61	.	.	PROPN
admet-1513	938	62	schinkel	schinkel	PROPN
admet-1513	938	63	.	.	PUNCT
admet-1513	939	1	complete	complete	ADJ
admet-1513	939	2	oatp1b1	oatp1b1	NOUN
admet-1513	939	3	and	and	CCONJ
admet-1513	939	4	oatp1b3	oatp1b3	NOUN
admet-1513	939	5	deficiency	deficiency	NOUN
admet-1513	939	6	causes	cause	VERB
admet-1513	939	7	human	human	ADJ
admet-1513	939	8	rotor	rotor	NOUN
admet-1513	939	9	syndrome	syndrome	NOUN
admet-1513	939	10	by	by	ADP
admet-1513	939	11	interrupting	interrupt	VERB
admet-1513	939	12	conjugated	conjugated	ADJ
admet-1513	939	13	bilirubin	bilirubin	NOUN
admet-1513	939	14	reuptake	reuptake	NOUN
admet-1513	939	15	into	into	ADP
admet-1513	939	16	the	the	DET
admet-1513	939	17	liver	liver	NOUN
admet-1513	939	18	.	.	PUNCT
admet-1513	940	1	j.	j.	PROPN
admet-1513	940	2	clin	clin	PROPN
admet-1513	940	3	.	.	PUNCT
admet-1513	941	1	invest	invest	VERB
admet-1513	941	2	.	.	PUNCT
admet-1513	942	1	122	122	NUM
admet-1513	942	2	(	(	PUNCT
admet-1513	942	3	2012	2012	NUM
admet-1513	942	4	)	)	PUNCT
admet-1513	942	5	519	519	NUM
admet-1513	942	6	-	-	SYM
admet-1513	942	7	528	528	NUM
admet-1513	942	8	.	.	PUNCT
admet-1513	943	1	https://doi.org/10.1172/jci59526	https://doi.org/10.1172/jci59526	VERB
admet-1513	943	2	.	.	PUNCT
admet-1513	944	1	[	[	X
admet-1513	944	2	83	83	NUM
admet-1513	944	3	]	]	X
admet-1513	944	4	l.j	l.j	PROPN
admet-1513	944	5	.	.	PROPN
admet-1513	944	6	stevens	stevens	PROPN
admet-1513	944	7	,	,	PUNCT
admet-1513	944	8	j.m	j.m	PROPN
admet-1513	944	9	.	.	PROPN
admet-1513	944	10	donkers	donker	NOUN
admet-1513	944	11	,	,	PUNCT
admet-1513	944	12	j.	j.	PROPN
admet-1513	944	13	dubbeld	dubbeld	PROPN
admet-1513	944	14	,	,	PUNCT
admet-1513	944	15	w.h.j	w.h.j	ADJ
admet-1513	944	16	.	.	PUNCT
admet-1513	945	1	vaes	vaes	ADJ
admet-1513	945	2	,	,	PUNCT
admet-1513	945	3	c.a.j	c.a.j	ADJ
admet-1513	945	4	.	.	PUNCT
admet-1513	945	5	knibbe	knibbe	PROPN
admet-1513	945	6	,	,	PUNCT
admet-1513	945	7	i.p.j	i.p.j	NOUN
admet-1513	945	8	.	.	PUNCT
admet-1513	946	1	alwayn	alwayn	PROPN
admet-1513	946	2	,	,	PUNCT
admet-1513	946	3	e.	e.	PROPN
admet-1513	946	4	van	van	PROPN
admet-1513	946	5	de	de	PROPN
admet-1513	946	6	steeg	steeg	PROPN
admet-1513	946	7	.	.	PROPN
admet-1513	947	1	towards	towards	ADP
admet-1513	947	2	human	human	PROPN
admet-1513	947	3	ex	ex	X
admet-1513	947	4	vivo	vivo	NOUN
admet-1513	947	5	organ	organ	NOUN
admet-1513	947	6	perfusion	perfusion	NOUN
admet-1513	947	7	models	model	NOUN
admet-1513	948	1	to	to	PART
admet-1513	948	2	elucidate	elucidate	VERB
admet-1513	948	3	drug	drug	NOUN
admet-1513	948	4	pharmacokinetics	pharmacokinetic	NOUN
admet-1513	948	5	in	in	ADP
admet-1513	948	6	health	health	NOUN
admet-1513	948	7	and	and	CCONJ
admet-1513	948	8	disease	disease	NOUN
admet-1513	949	1	.	.	PUNCT
admet-1513	950	1	drug	drug	NOUN
admet-1513	950	2	metab	metab	PROPN
admet-1513	950	3	.	.	PUNCT
admet-1513	951	1	rev	rev	PROPN
admet-1513	951	2	.	.	PROPN
admet-1513	951	3	52	52	NUM
admet-1513	951	4	(	(	PUNCT
admet-1513	951	5	2020	2020	NUM
admet-1513	951	6	)	)	PUNCT
admet-1513	951	7	438	438	NUM
admet-1513	951	8	-	-	SYM
admet-1513	951	9	454	454	NUM
admet-1513	951	10	.	.	PUNCT
admet-1513	952	1	https://doi.org/10.1080/03602532.2020.1772280	https://doi.org/10.1080/03602532.2020.1772280	NOUN
admet-1513	952	2	.	.	PUNCT
admet-1513	953	1	[	[	X
admet-1513	953	2	84	84	NUM
admet-1513	953	3	]	]	X
admet-1513	953	4	p.s	p.s	INTJ
admet-1513	953	5	.	.	PUNCT
admet-1513	953	6	khakar	khakar	PROPN
admet-1513	953	7	.	.	PUNCT
admet-1513	954	1	two	two	NUM
admet-1513	954	2	-	-	PUNCT
admet-1513	954	3	dimensional	dimensional	ADJ
admet-1513	954	4	(	(	PUNCT
admet-1513	954	5	2d	2d	NOUN
admet-1513	954	6	)	)	PUNCT
admet-1513	954	7	in	in	ADP
admet-1513	954	8	silico	silico	NOUN
admet-1513	954	9	models	model	NOUN
admet-1513	954	10	for	for	ADP
admet-1513	954	11	absorption	absorption	NOUN
admet-1513	954	12	,	,	PUNCT
admet-1513	954	13	distribution	distribution	NOUN
admet-1513	954	14	,	,	PUNCT
admet-1513	954	15	metabolism	metabolism	NOUN
admet-1513	954	16	,	,	PUNCT
admet-1513	954	17	excretion	excretion	NOUN
admet-1513	954	18	and	and	CCONJ
admet-1513	954	19	toxicity	toxicity	NOUN
admet-1513	954	20	(	(	PUNCT
admet-1513	954	21	adme	adme	PROPN
admet-1513	954	22	/	/	SYM
admet-1513	954	23	t	t	NOUN
admet-1513	954	24	)	)	PUNCT
admet-1513	954	25	in	in	ADP
admet-1513	954	26	drug	drug	NOUN
admet-1513	954	27	discovery	discovery	NOUN
admet-1513	954	28	.	.	PUNCT
admet-1513	955	1	curr	curr	PROPN
admet-1513	955	2	.	.	PUNCT
admet-1513	956	1	top	top	PROPN
admet-1513	956	2	.	.	PUNCT
admet-1513	957	1	med	med	PROPN
admet-1513	957	2	.	.	PROPN
admet-1513	957	3	chem	chem	PROPN
admet-1513	957	4	.	.	PUNCT
admet-1513	958	1	10	10	NUM
admet-1513	958	2	(	(	PUNCT
admet-1513	958	3	2010	2010	NUM
admet-1513	958	4	)	)	PUNCT
admet-1513	958	5	116	116	NUM
admet-1513	958	6	-	-	SYM
admet-1513	958	7	126	126	NUM
admet-1513	958	8	.	.	PUNCT
admet-1513	959	1	https://doi.org/10.2174/156802610790232224	https://doi.org/10.2174/156802610790232224	NOUN
admet-1513	959	2	.	.	PUNCT
admet-1513	960	1	[	[	X
admet-1513	960	2	85	85	NUM
admet-1513	960	3	]	]	X
admet-1513	960	4	c.k	c.k	PROPN
admet-1513	960	5	.	.	PROPN
admet-1513	960	6	nwabufo	nwabufo	PROPN
admet-1513	960	7	.	.	PUNCT
admet-1513	961	1	relevance	relevance	NOUN
admet-1513	961	2	of	of	ADP
admet-1513	961	3	abc	abc	PROPN
admet-1513	961	4	transporters	transporter	NOUN
admet-1513	961	5	in	in	ADP
admet-1513	961	6	drug	drug	NOUN
admet-1513	961	7	development	development	NOUN
admet-1513	961	8	.	.	PUNCT
admet-1513	962	1	curr	curr	PROPN
admet-1513	962	2	.	.	PUNCT
admet-1513	962	3	drug	drug	PROPN
admet-1513	962	4	metab	metab	NOUN
admet-1513	962	5	.	.	PUNCT
admet-1513	963	1	23	23	NUM
admet-1513	963	2	(	(	PUNCT
admet-1513	963	3	2022	2022	NUM
admet-1513	963	4	)	)	PUNCT
admet-1513	963	5	434	434	NUM
admet-1513	963	6	-	-	SYM
admet-1513	963	7	446	446	NUM
admet-1513	963	8	.	.	PUNCT
admet-1513	964	1	https:/doi.org/10.2174/1389200223666220621113524	https:/doi.org/10.2174/1389200223666220621113524	PROPN
admet-1513	964	2	https://doi.org/10.1080/03602530601093489	https://doi.org/10.1080/03602530601093489	PROPN
admet-1513	964	3	https://doi.org/10.1007/978-1-4939-2074-7_5	https://doi.org/10.1007/978-1-4939-2074-7_5	NOUN
admet-1513	965	1	https://doi.org/10.1007/978-1-4939-2074-7_5	https://doi.org/10.1007/978-1-4939-2074-7_5	NOUN
admet-1513	965	2	https://doi.org/10.1080/00498250210128675	https://doi.org/10.1080/00498250210128675	NOUN
admet-1513	965	3	https://doi.org/10.3389/fgene.2020.546106	https://doi.org/10.3389/fgene.2020.546106	PROPN
admet-1513	965	4	https://doi.org/10.1080/00498250802613620	https://doi.org/10.1080/00498250802613620	X
admet-1513	965	5	https://doi.org/10.1007/s00204-011-0733-y	https://doi.org/10.1007/s00204-011-0733-y	PROPN
admet-1513	965	6	https://doi.org/10.1007/978-1-60761-688-7_13	https://doi.org/10.1007/978-1-60761-688-7_13	PROPN
admet-1513	965	7	https://doi.org/10.2174/1389200219666180523095355	https://doi.org/10.2174/1389200219666180523095355	PROPN
admet-1513	965	8	https://doi.org/10.1007/s10565-011-9208-4	https://doi.org/10.1007/s10565-011-9208-4	NUM
admet-1513	965	9	https://doi.org/10.1172/jci59526	https://doi.org/10.1172/jci59526	VERB
admet-1513	965	10	https://doi.org/10.1080/03602532.2020.1772280	https://doi.org/10.1080/03602532.2020.1772280	ADV
admet-1513	965	11	https://doi.org/10.2174/156802610790232224	https://doi.org/10.2174/156802610790232224	NOUN
admet-1513	965	12	https://doi.org/10.2174/156802610790232224	https://doi.org/10.2174/156802610790232224	X
admet-1513	965	13	https://doi.org/10.2174/1389200223666220621113524	https://doi.org/10.2174/1389200223666220621113524	PROPN
admet-1513	965	14	admet	admet	PROPN
admet-1513	965	15	&	&	CCONJ
admet-1513	965	16	dmpk	dmpk	PROPN
admet-1513	965	17	11(1	11(1	NUM
admet-1513	965	18	)	)	PUNCT
admet-1513	965	19	(	(	PUNCT
admet-1513	965	20	2023	2023	NUM
admet-1513	965	21	)	)	PUNCT
admet-1513	965	22	1	1	NUM
admet-1513	965	23	-	-	SYM
admet-1513	965	24	32	32	NUM
admet-1513	965	25	2d	2d	NOUN
admet-1513	965	26	and	and	CCONJ
admet-1513	965	27	3d	3d	NOUN
admet-1513	965	28	adme	adme	PROPN
admet-1513	965	29	-	-	PUNCT
admet-1513	965	30	tox	tox	NOUN
admet-1513	965	31	cell	cell	NOUN
admet-1513	965	32	culture	culture	NOUN
admet-1513	965	33	screening	screen	VERB
admet-1513	965	34	:	:	PUNCT
admet-1513	965	35	a	a	DET
admet-1513	965	36	review	review	NOUN
admet-1513	965	37	doi	doi	NOUN
admet-1513	965	38	:	:	PUNCT
admet-1513	965	39	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	965	40	23	23	NUM
admet-1513	966	1	[	[	SYM
admet-1513	966	2	86	86	NUM
admet-1513	966	3	]	]	X
admet-1513	966	4	g.	g.	PROPN
admet-1513	966	5	pan	pan	PROPN
admet-1513	966	6	.	.	PROPN
admet-1513	967	1	roles	role	NOUN
admet-1513	967	2	of	of	ADP
admet-1513	967	3	hepatic	hepatic	ADJ
admet-1513	967	4	drug	drug	NOUN
admet-1513	967	5	transporters	transporter	NOUN
admet-1513	967	6	in	in	ADP
admet-1513	967	7	drug	drug	NOUN
admet-1513	967	8	disposition	disposition	NOUN
admet-1513	967	9	and	and	CCONJ
admet-1513	967	10	liver	liver	NOUN
admet-1513	967	11	toxicity	toxicity	NOUN
admet-1513	967	12	.	.	PUNCT
admet-1513	968	1	adv	adv	PROPN
admet-1513	968	2	.	.	PUNCT
admet-1513	969	1	exp	exp	PROPN
admet-1513	969	2	.	.	PROPN
admet-1513	969	3	med	med	PROPN
admet-1513	969	4	.	.	PUNCT
admet-1513	970	1	biol	biol	PROPN
admet-1513	970	2	.	.	PUNCT
admet-1513	971	1	1141	1141	NUM
admet-1513	971	2	(	(	PUNCT
admet-1513	971	3	2019	2019	NUM
admet-1513	971	4	)	)	PUNCT
admet-1513	971	5	293	293	NUM
admet-1513	971	6	-	-	SYM
admet-1513	971	7	340	340	NUM
admet-1513	971	8	.	.	PUNCT
admet-1513	972	1	https://doi.org/10.1007/978-981-13-7647-4_6	https://doi.org/10.1007/978-981-13-7647-4_6	PROPN
admet-1513	972	2	.	.	PUNCT
admet-1513	973	1	[	[	X
admet-1513	973	2	87	87	NUM
admet-1513	973	3	]	]	PUNCT
admet-1513	973	4	g.	g.	PROPN
admet-1513	973	5	williamson	williamson	PROPN
admet-1513	973	6	,	,	PUNCT
admet-1513	973	7	i.	i.	PROPN
admet-1513	973	8	aeberli	aeberli	PROPN
admet-1513	973	9	,	,	PUNCT
admet-1513	973	10	l.	l.	PROPN
admet-1513	973	11	miguet	miguet	PROPN
admet-1513	973	12	,	,	PUNCT
admet-1513	973	13	z.	z.	PROPN
admet-1513	973	14	zhang	zhang	PROPN
admet-1513	973	15	,	,	PUNCT
admet-1513	973	16	m.b	m.b	PROPN
admet-1513	973	17	.	.	PROPN
admet-1513	973	18	sanchez	sanchez	PROPN
admet-1513	973	19	,	,	PUNCT
admet-1513	973	20	v.	v.	PROPN
admet-1513	973	21	crespy	crespy	PROPN
admet-1513	973	22	,	,	PUNCT
admet-1513	973	23	d.	d.	PROPN
admet-1513	973	24	barron	barron	PROPN
admet-1513	973	25	,	,	PUNCT
admet-1513	973	26	p.	p.	PROPN
admet-1513	973	27	needs	need	NOUN
admet-1513	973	28	,	,	PUNCT
admet-1513	973	29	p.a	p.a	PROPN
admet-1513	973	30	.	.	PROPN
admet-1513	973	31	kroon	kroon	PROPN
admet-1513	973	32	,	,	PUNCT
admet-1513	973	33	h.	h.	PROPN
admet-1513	973	34	glavinas	glavinas	PROPN
admet-1513	973	35	,	,	PUNCT
admet-1513	973	36	p.	p.	PROPN
admet-1513	973	37	krajcsi	krajcsi	PROPN
admet-1513	973	38	,	,	PUNCT
admet-1513	973	39	m.	m.	NOUN
admet-1513	973	40	grigorov	grigorov	NOUN
admet-1513	973	41	.	.	PUNCT
admet-1513	974	1	interaction	interaction	NOUN
admet-1513	974	2	of	of	ADP
admet-1513	974	3	positional	positional	ADJ
admet-1513	974	4	isomers	isomer	NOUN
admet-1513	974	5	of	of	ADP
admet-1513	974	6	quercetin	quercetin	NOUN
admet-1513	974	7	glucuronides	glucuronide	NOUN
admet-1513	974	8	with	with	ADP
admet-1513	974	9	the	the	DET
admet-1513	974	10	transporter	transporter	NOUN
admet-1513	974	11	abcc2	abcc2	NOUN
admet-1513	974	12	(	(	PUNCT
admet-1513	974	13	cmoat	cmoat	PROPN
admet-1513	974	14	,	,	PUNCT
admet-1513	974	15	mrp2	mrp2	PROPN
admet-1513	974	16	)	)	PUNCT
admet-1513	974	17	.	.	PUNCT
admet-1513	975	1	drug	drug	NOUN
admet-1513	975	2	metab	metab	PROPN
admet-1513	975	3	.	.	PUNCT
admet-1513	976	1	dispos	dispos	PROPN
admet-1513	976	2	.	.	PUNCT
admet-1513	977	1	35	35	NUM
admet-1513	977	2	(	(	PUNCT
admet-1513	977	3	2007	2007	NUM
admet-1513	977	4	)	)	PUNCT
admet-1513	977	5	1262	1262	NUM
admet-1513	977	6	-	-	SYM
admet-1513	977	7	1268	1268	NUM
admet-1513	977	8	.	.	PUNCT
admet-1513	978	1	https://doi.org/10.1124/dmd.106.014241	https://doi.org/10.1124/dmd.106.014241	VERB
admet-1513	978	2	.	.	PUNCT
admet-1513	979	1	[	[	X
admet-1513	979	2	88	88	NUM
admet-1513	979	3	]	]	X
admet-1513	979	4	f.j	f.j	PROPN
admet-1513	979	5	.	.	PROPN
admet-1513	979	6	sharom	sharom	PROPN
admet-1513	979	7	,	,	PUNCT
admet-1513	979	8	x.	x.	PROPN
admet-1513	979	9	yu	yu	PROPN
admet-1513	979	10	,	,	PUNCT
admet-1513	979	11	p.	p.	PROPN
admet-1513	979	12	lu	lu	PROPN
admet-1513	979	13	,	,	PUNCT
admet-1513	979	14	r.	r.	PROPN
admet-1513	979	15	liu	liu	PROPN
admet-1513	979	16	,	,	PUNCT
admet-1513	979	17	j.w	j.w	PROPN
admet-1513	979	18	.	.	PROPN
admet-1513	979	19	chu	chu	PROPN
admet-1513	979	20	,	,	PUNCT
admet-1513	979	21	k.	k.	PROPN
admet-1513	979	22	szabó	szabó	PROPN
admet-1513	979	23	,	,	PUNCT
admet-1513	979	24	m.	m.	NOUN
admet-1513	979	25	müller	müller	PROPN
admet-1513	979	26	,	,	PUNCT
admet-1513	979	27	c.d	c.d	PROPN
admet-1513	979	28	.	.	PROPN
admet-1513	979	29	hose	hose	PROPN
admet-1513	979	30	,	,	PUNCT
admet-1513	979	31	a.	a.	NOUN
admet-1513	979	32	monks	monk	NOUN
admet-1513	979	33	,	,	PUNCT
admet-1513	979	34	a.	a.	NOUN
admet-1513	979	35	váradi	váradi	PROPN
admet-1513	979	36	,	,	PUNCT
admet-1513	979	37	j.	j.	PROPN
admet-1513	979	38	seprôdi	seprôdi	PROPN
admet-1513	979	39	,	,	PUNCT
admet-1513	979	40	b.	b.	PROPN
admet-1513	979	41	sarkadi	sarkadi	PROPN
admet-1513	979	42	.	.	PUNCT
admet-1513	980	1	interaction	interaction	NOUN
admet-1513	980	2	of	of	ADP
admet-1513	980	3	the	the	DET
admet-1513	980	4	p	p	NOUN
admet-1513	980	5	-	-	PUNCT
admet-1513	980	6	glycoprotein	glycoprotein	NOUN
admet-1513	980	7	multidrug	multidrug	NOUN
admet-1513	980	8	transporter	transporter	NOUN
admet-1513	980	9	(	(	PUNCT
admet-1513	980	10	mdr1	mdr1	PROPN
admet-1513	980	11	)	)	PUNCT
admet-1513	980	12	with	with	ADP
admet-1513	980	13	high	high	ADJ
admet-1513	980	14	affinity	affinity	NOUN
admet-1513	980	15	peptide	peptide	NOUN
admet-1513	980	16	chemosensitizers	chemosensitizer	NOUN
admet-1513	980	17	in	in	ADP
admet-1513	980	18	isolated	isolated	ADJ
admet-1513	980	19	membranes	membrane	NOUN
admet-1513	980	20	,	,	PUNCT
admet-1513	980	21	reconstituted	reconstitute	VERB
admet-1513	980	22	systems	system	NOUN
admet-1513	980	23	,	,	PUNCT
admet-1513	980	24	and	and	CCONJ
admet-1513	980	25	intact	intact	ADJ
admet-1513	980	26	cells	cell	NOUN
admet-1513	980	27	.	.	PUNCT
admet-1513	981	1	biochem	biochem	PROPN
admet-1513	981	2	.	.	PUNCT
admet-1513	982	1	pharmacol	pharmacol	PROPN
admet-1513	982	2	.	.	PUNCT
admet-1513	983	1	58	58	NUM
admet-1513	983	2	(	(	PUNCT
admet-1513	983	3	1999	1999	NUM
admet-1513	983	4	)	)	PUNCT
admet-1513	983	5	571	571	NUM
admet-1513	983	6	-	-	SYM
admet-1513	983	7	586	586	NUM
admet-1513	983	8	.	.	PUNCT
admet-1513	984	1	https://doi.org/10.1016/s0006-2952(99)00139-2	https://doi.org/10.1016/s0006-2952(99)00139-2	PROPN
admet-1513	984	2	.	.	PUNCT
admet-1513	985	1	[	[	X
admet-1513	985	2	89	89	NUM
admet-1513	985	3	]	]	X
admet-1513	985	4	d.	d.	PROPN
admet-1513	985	5	wang	wang	PROPN
admet-1513	985	6	.	.	PUNCT
admet-1513	986	1	current	current	ADJ
admet-1513	986	2	research	research	NOUN
admet-1513	986	3	method	method	NOUN
admet-1513	986	4	in	in	ADP
admet-1513	986	5	transporter	transporter	NOUN
admet-1513	986	6	study	study	NOUN
admet-1513	986	7	.	.	PUNCT
admet-1513	987	1	adv	adv	PROPN
admet-1513	987	2	.	.	PUNCT
admet-1513	988	1	exp	exp	PROPN
admet-1513	988	2	.	.	PROPN
admet-1513	988	3	med	med	PROPN
admet-1513	988	4	.	.	PUNCT
admet-1513	989	1	biol	biol	PROPN
admet-1513	989	2	.	.	PUNCT
admet-1513	990	1	1141	1141	NUM
admet-1513	990	2	(	(	PUNCT
admet-1513	990	3	2019	2019	NUM
admet-1513	990	4	)	)	PUNCT
admet-1513	990	5	203	203	NUM
admet-1513	990	6	-	-	SYM
admet-1513	990	7	240	240	NUM
admet-1513	990	8	.	.	PUNCT
admet-1513	990	9	https://doi.org/10.1007/978-981-13-7647-4_4	https://doi.org/10.1007/978-981-13-7647-4_4	PROPN
admet-1513	991	1	[	[	X
admet-1513	991	2	90	90	NUM
admet-1513	991	3	]	]	X
admet-1513	991	4	f.l	f.l	PROPN
admet-1513	991	5	.	.	PROPN
admet-1513	991	6	graham	graham	PROPN
admet-1513	991	7	,	,	PUNCT
admet-1513	991	8	j.	j.	PROPN
admet-1513	991	9	smiley	smiley	PROPN
admet-1513	991	10	,	,	PUNCT
admet-1513	991	11	w.c	w.c	PROPN
admet-1513	991	12	.	.	PROPN
admet-1513	991	13	russell	russell	PROPN
admet-1513	991	14	,	,	PUNCT
admet-1513	991	15	r.	r.	PROPN
admet-1513	991	16	nairn	nairn	PROPN
admet-1513	991	17	.	.	PUNCT
admet-1513	992	1	characteristics	characteristic	NOUN
admet-1513	992	2	of	of	ADP
admet-1513	992	3	a	a	DET
admet-1513	992	4	human	human	ADJ
admet-1513	992	5	cell	cell	NOUN
admet-1513	992	6	line	line	NOUN
admet-1513	992	7	transformed	transform	VERB
admet-1513	992	8	by	by	ADP
admet-1513	992	9	dna	dna	PROPN
admet-1513	992	10	from	from	ADP
admet-1513	992	11	human	human	ADJ
admet-1513	992	12	adenovirus	adenovirus	NOUN
admet-1513	992	13	type	type	NOUN
admet-1513	992	14	5	5	NUM
admet-1513	992	15	.	.	PUNCT
admet-1513	992	16	j.	j.	PROPN
admet-1513	992	17	gen	gen	PROPN
admet-1513	992	18	.	.	PROPN
admet-1513	992	19	virol	virol	PROPN
admet-1513	992	20	.	.	PUNCT
admet-1513	993	1	36	36	NUM
admet-1513	993	2	(	(	PUNCT
admet-1513	993	3	1977	1977	NUM
admet-1513	993	4	)	)	PUNCT
admet-1513	993	5	59	59	NUM
admet-1513	993	6	-	-	SYM
admet-1513	993	7	74	74	NUM
admet-1513	993	8	.	.	PUNCT
admet-1513	994	1	https://doi.org/10.1099/0022-131736-1-59	https://doi.org/10.1099/0022-131736-1-59	VERB
admet-1513	995	1	[	[	X
admet-1513	995	2	91	91	NUM
admet-1513	995	3	]	]	X
admet-1513	995	4	c.	c.	PROPN
admet-1513	995	5	hilgendorf	hilgendorf	PROPN
admet-1513	995	6	,	,	PUNCT
admet-1513	995	7	g.	g.	PROPN
admet-1513	995	8	ahlin	ahlin	PROPN
admet-1513	995	9	,	,	PUNCT
admet-1513	995	10	a.	a.	NOUN
admet-1513	995	11	seithel	seithel	PROPN
admet-1513	995	12	,	,	PUNCT
admet-1513	995	13	p.	p.	PROPN
admet-1513	995	14	artursson	artursson	PROPN
admet-1513	995	15	,	,	PUNCT
admet-1513	995	16	a.l	a.l	PROPN
admet-1513	995	17	.	.	PROPN
admet-1513	995	18	ungell	ungell	PROPN
admet-1513	995	19	,	,	PUNCT
admet-1513	995	20	j.	j.	PROPN
admet-1513	995	21	karlsson	karlsson	PROPN
admet-1513	995	22	.	.	PUNCT
admet-1513	996	1	expression	expression	NOUN
admet-1513	996	2	of	of	ADP
admet-1513	996	3	thirty	thirty	NUM
admet-1513	996	4	-	-	PUNCT
admet-1513	996	5	six	six	NUM
admet-1513	996	6	drug	drug	NOUN
admet-1513	996	7	transporter	transporter	NOUN
admet-1513	996	8	genes	gene	NOUN
admet-1513	996	9	in	in	ADP
admet-1513	996	10	human	human	ADJ
admet-1513	996	11	intestine	intestine	NOUN
admet-1513	996	12	,	,	PUNCT
admet-1513	996	13	liver	liver	NOUN
admet-1513	996	14	,	,	PUNCT
admet-1513	996	15	kidney	kidney	NOUN
admet-1513	996	16	,	,	PUNCT
admet-1513	996	17	and	and	CCONJ
admet-1513	996	18	organotypic	organotypic	ADJ
admet-1513	996	19	cell	cell	NOUN
admet-1513	996	20	lines	line	NOUN
admet-1513	996	21	.	.	PUNCT
admet-1513	997	1	drug	drug	NOUN
admet-1513	997	2	metab	metab	NOUN
admet-1513	997	3	.	.	PUNCT
admet-1513	998	1	dispos	dispos	PROPN
admet-1513	998	2	.	.	PUNCT
admet-1513	999	1	35	35	NUM
admet-1513	999	2	(	(	PUNCT
admet-1513	999	3	2007	2007	NUM
admet-1513	999	4	)	)	PUNCT
admet-1513	999	5	1333	1333	NUM
admet-1513	999	6	-	-	SYM
admet-1513	999	7	1340	1340	NUM
admet-1513	999	8	.	.	PUNCT
admet-1513	1000	1	https://doi.org/10.1124/dmd.107.014902	https://doi.org/10.1124/dmd.107.014902	VERB
admet-1513	1001	1	[	[	X
admet-1513	1001	2	92	92	NUM
admet-1513	1001	3	]	]	X
admet-1513	1001	4	m.m	m.m	PROPN
admet-1513	1001	5	.	.	PROPN
admet-1513	1001	6	parvez	parvez	PROPN
admet-1513	1001	7	,	,	PUNCT
admet-1513	1001	8	j.a	j.a	PROPN
admet-1513	1001	9	.	.	PROPN
admet-1513	1001	10	jung	jung	PROPN
admet-1513	1001	11	,	,	PUNCT
admet-1513	1001	12	h.j	h.j	PROPN
admet-1513	1001	13	.	.	PROPN
admet-1513	1001	14	shin	shin	PROPN
admet-1513	1001	15	,	,	PUNCT
admet-1513	1001	16	d.h	d.h	PROPN
admet-1513	1001	17	.	.	PROPN
admet-1513	1001	18	kim	kim	PROPN
admet-1513	1001	19	,	,	PUNCT
admet-1513	1001	20	j.g	j.g	PROPN
admet-1513	1001	21	.	.	PROPN
admet-1513	1001	22	shin	shin	PROPN
admet-1513	1001	23	.	.	PUNCT
admet-1513	1002	1	characterization	characterization	NOUN
admet-1513	1002	2	of	of	ADP
admet-1513	1002	3	22	22	NUM
admet-1513	1002	4	antituberculosis	antituberculosis	NOUN
admet-1513	1002	5	drugs	drug	NOUN
admet-1513	1002	6	for	for	ADP
admet-1513	1002	7	inhibitory	inhibitory	ADJ
admet-1513	1002	8	interaction	interaction	NOUN
admet-1513	1002	9	potential	potential	NOUN
admet-1513	1002	10	on	on	ADP
admet-1513	1002	11	organic	organic	ADJ
admet-1513	1002	12	anionic	anionic	ADJ
admet-1513	1002	13	transporter	transporter	NOUN
admet-1513	1002	14	polypeptide	polypeptide	ADJ
admet-1513	1002	15	(	(	PUNCT
admet-1513	1002	16	oatp)-mediated	oatp)-mediated	ADJ
admet-1513	1002	17	uptake	uptake	NOUN
admet-1513	1002	18	.	.	PUNCT
admet-1513	1003	1	antimicrob	antimicrob	PROPN
admet-1513	1003	2	.	.	PUNCT
admet-1513	1004	1	agents	agent	NOUN
admet-1513	1004	2	chemother	chemother	PROPN
admet-1513	1004	3	.	.	PUNCT
admet-1513	1005	1	60	60	NUM
admet-1513	1005	2	(	(	PUNCT
admet-1513	1005	3	2016	2016	NUM
admet-1513	1005	4	)	)	PUNCT
admet-1513	1005	5	3096	3096	NUM
admet-1513	1005	6	-	-	SYM
admet-1513	1005	7	3105	3105	NUM
admet-1513	1005	8	.	.	PUNCT
admet-1513	1006	1	https://doi.org/10.1128/aac.0276515	https://doi.org/10.1128/aac.0276515	NOUN
admet-1513	1006	2	[	[	X
admet-1513	1006	3	93	93	NUM
admet-1513	1006	4	]	]	PUNCT
admet-1513	1006	5	p.	p.	PROPN
admet-1513	1006	6	srivastava	srivastava	PROPN
admet-1513	1006	7	,	,	PUNCT
admet-1513	1006	8	m.	m.	PROPN
admet-1513	1006	9	kumar	kumar	PROPN
admet-1513	1006	10	,	,	PUNCT
admet-1513	1006	11	p.k	p.k	PROPN
admet-1513	1006	12	.	.	PROPN
admet-1513	1006	13	nayak	nayak	PROPN
admet-1513	1006	14	.	.	PUNCT
admet-1513	1007	1	role	role	NOUN
admet-1513	1007	2	of	of	ADP
admet-1513	1007	3	patient	patient	ADJ
admet-1513	1007	4	derived	derive	VERB
admet-1513	1007	5	cell	cell	NOUN
admet-1513	1007	6	lines	line	NOUN
admet-1513	1007	7	and	and	CCONJ
admet-1513	1007	8	xenograft	xenograft	NOUN
admet-1513	1007	9	in	in	ADP
admet-1513	1007	10	cancer	cancer	NOUN
admet-1513	1007	11	research	research	NOUN
admet-1513	1007	12	.	.	PUNCT
admet-1513	1008	1	the	the	DET
admet-1513	1008	2	pharmstudent	pharmstudent	ADJ
admet-1513	1008	3	27	27	NUM
admet-1513	1008	4	(	(	PUNCT
admet-1513	1008	5	2016	2016	NUM
admet-1513	1008	6	)	)	PUNCT
admet-1513	1008	7	40	40	NUM
admet-1513	1008	8	-	-	SYM
admet-1513	1008	9	48	48	NUM
admet-1513	1008	10	.	.	PUNCT
admet-1513	1009	1	[	[	X
admet-1513	1009	2	94	94	X
admet-1513	1009	3	]	]	X
admet-1513	1009	4	r.k	r.k	PROPN
admet-1513	1009	5	.	.	PROPN
admet-1513	1009	6	harrison	harrison	PROPN
admet-1513	1009	7	.	.	PUNCT
admet-1513	1009	8	phase	phase	PROPN
admet-1513	1009	9	ii	ii	PROPN
admet-1513	1009	10	and	and	CCONJ
admet-1513	1009	11	phase	phase	NOUN
admet-1513	1009	12	iii	iii	NUM
admet-1513	1009	13	failures	failure	NOUN
admet-1513	1009	14	:	:	PUNCT
admet-1513	1009	15	2013	2013	NUM
admet-1513	1009	16	-	-	SYM
admet-1513	1009	17	2015	2015	NUM
admet-1513	1009	18	.	.	PUNCT
admet-1513	1010	1	nat	nat	PROPN
admet-1513	1010	2	.	.	PUNCT
admet-1513	1011	1	rev	rev	PROPN
admet-1513	1011	2	.	.	PROPN
admet-1513	1011	3	drug	drug	NOUN
admet-1513	1011	4	discov	discov	NOUN
admet-1513	1011	5	.	.	PUNCT
admet-1513	1012	1	15	15	NUM
admet-1513	1012	2	(	(	PUNCT
admet-1513	1012	3	2016	2016	NUM
admet-1513	1012	4	)	)	PUNCT
admet-1513	1012	5	817	817	NUM
admet-1513	1012	6	-	-	SYM
admet-1513	1012	7	818	818	NUM
admet-1513	1012	8	.	.	PUNCT
admet-1513	1013	1	https://doi.org/10.1038/nrd.2016.184	https://doi.org/10.1038/nrd.2016.184	X
admet-1513	1013	2	.	.	PUNCT
admet-1513	1014	1	[	[	X
admet-1513	1014	2	95	95	NUM
admet-1513	1014	3	]	]	X
admet-1513	1014	4	d.	d.	PROPN
admet-1513	1014	5	tuveson	tuveson	PROPN
admet-1513	1014	6	,	,	PUNCT
admet-1513	1014	7	h.	h.	PROPN
admet-1513	1014	8	clevers	clevers	PROPN
admet-1513	1014	9	.	.	PUNCT
admet-1513	1015	1	cancer	cancer	NOUN
admet-1513	1015	2	modeling	modeling	NOUN
admet-1513	1015	3	meets	meet	VERB
admet-1513	1015	4	human	human	ADJ
admet-1513	1015	5	organoid	organoid	PROPN
admet-1513	1015	6	technology	technology	NOUN
admet-1513	1015	7	.	.	PUNCT
admet-1513	1016	1	science	science	NOUN
admet-1513	1016	2	364	364	NUM
admet-1513	1016	3	(	(	PUNCT
admet-1513	1016	4	2019	2019	NUM
admet-1513	1016	5	)	)	PUNCT
admet-1513	1016	6	952955	952955	NUM
admet-1513	1016	7	.	.	PUNCT
admet-1513	1017	1	https://doi.org/10.1126/science.aaw6985	https://doi.org/10.1126/science.aaw6985	PROPN
admet-1513	1017	2	.	.	PUNCT
admet-1513	1018	1	[	[	X
admet-1513	1018	2	96	96	NUM
admet-1513	1018	3	]	]	X
admet-1513	1018	4	f.	f.	NOUN
admet-1513	1018	5	pampaloni	pampaloni	PROPN
admet-1513	1018	6	,	,	PUNCT
admet-1513	1018	7	e.g.	e.g.	ADV
admet-1513	1018	8	reynaud	reynaud	NOUN
admet-1513	1018	9	,	,	PUNCT
admet-1513	1018	10	e.h	e.h	PROPN
admet-1513	1018	11	.	.	PROPN
admet-1513	1018	12	stelzer	stelzer	NOUN
admet-1513	1018	13	.	.	PUNCT
admet-1513	1019	1	the	the	DET
admet-1513	1019	2	third	third	ADJ
admet-1513	1019	3	dimension	dimension	NOUN
admet-1513	1019	4	bridges	bridge	NOUN
admet-1513	1019	5	the	the	DET
admet-1513	1019	6	gap	gap	NOUN
admet-1513	1019	7	between	between	ADP
admet-1513	1019	8	cell	cell	NOUN
admet-1513	1019	9	culture	culture	NOUN
admet-1513	1019	10	and	and	CCONJ
admet-1513	1019	11	live	live	ADJ
admet-1513	1019	12	tissue	tissue	NOUN
admet-1513	1019	13	.	.	PUNCT
admet-1513	1020	1	nat	nat	PROPN
admet-1513	1020	2	.	.	PUNCT
admet-1513	1021	1	rev	rev	PROPN
admet-1513	1021	2	.	.	PROPN
admet-1513	1021	3	mol	mol	PROPN
admet-1513	1021	4	.	.	PROPN
admet-1513	1021	5	cell	cell	PROPN
admet-1513	1021	6	biol	biol	PROPN
admet-1513	1021	7	.	.	PUNCT
admet-1513	1022	1	8	8	NUM
admet-1513	1022	2	(	(	PUNCT
admet-1513	1022	3	2007	2007	NUM
admet-1513	1022	4	)	)	PUNCT
admet-1513	1022	5	839	839	NUM
admet-1513	1022	6	-	-	NUM
admet-1513	1022	7	845	845	NUM
admet-1513	1022	8	.	.	PUNCT
admet-1513	1023	1	https://doi.org/10.1038/nrm2236	https://doi.org/10.1038/nrm2236	VERB
admet-1513	1023	2	.	.	PUNCT
admet-1513	1024	1	[	[	X
admet-1513	1024	2	97	97	NUM
admet-1513	1024	3	]	]	X
admet-1513	1024	4	j.s	j.s	PROPN
admet-1513	1024	5	.	.	PROPN
admet-1513	1024	6	joseph	joseph	PROPN
admet-1513	1024	7	,	,	PUNCT
admet-1513	1024	8	s.t	s.t	PROPN
admet-1513	1024	9	.	.	PROPN
admet-1513	1024	10	malindisa	malindisa	PROPN
admet-1513	1024	11	,	,	PUNCT
admet-1513	1024	12	m.	m.	NOUN
admet-1513	1024	13	ntwasa	ntwasa	PROPN
admet-1513	1024	14	.	.	PUNCT
admet-1513	1025	1	two	two	NUM
admet-1513	1025	2	-	-	PUNCT
admet-1513	1025	3	dimensional	dimensional	ADJ
admet-1513	1025	4	(	(	PUNCT
admet-1513	1025	5	2d	2d	NOUN
admet-1513	1025	6	)	)	PUNCT
admet-1513	1025	7	and	and	CCONJ
admet-1513	1025	8	three	three	NUM
admet-1513	1025	9	-	-	PUNCT
admet-1513	1025	10	dimensional	dimensional	ADJ
admet-1513	1025	11	(	(	PUNCT
admet-1513	1025	12	3d	3d	NOUN
admet-1513	1025	13	)	)	PUNCT
admet-1513	1025	14	cell	cell	NOUN
admet-1513	1025	15	culturing	culture	VERB
admet-1513	1025	16	in	in	ADP
admet-1513	1025	17	drug	drug	NOUN
admet-1513	1025	18	discovery	discovery	NOUN
admet-1513	1025	19	.	.	PUNCT
admet-1513	1026	1	cell	cell	NOUN
admet-1513	1026	2	culture	culture	NOUN
admet-1513	1026	3	2	2	NUM
admet-1513	1026	4	(	(	PUNCT
admet-1513	1026	5	2018	2018	NUM
admet-1513	1026	6	)	)	PUNCT
admet-1513	1026	7	1	1	NUM
admet-1513	1026	8	-	-	SYM
admet-1513	1026	9	22	22	NUM
admet-1513	1026	10	.	.	PUNCT
admet-1513	1027	1	https://doi.org/10.5772/intechopen.81552	https://doi.org/10.5772/intechopen.81552	NOUN
admet-1513	1027	2	.	.	PUNCT
admet-1513	1028	1	[	[	X
admet-1513	1028	2	98	98	NUM
admet-1513	1028	3	]	]	X
admet-1513	1028	4	p.h	p.h	PROPN
admet-1513	1028	5	.	.	PROPN
admet-1513	1028	6	dedhia	dedhia	PROPN
admet-1513	1028	7	,	,	PUNCT
admet-1513	1028	8	n.	n.	NOUN
admet-1513	1028	9	bertaux	bertaux	PROPN
admet-1513	1028	10	-	-	PUNCT
admet-1513	1028	11	skeirik	skeirik	NOUN
admet-1513	1028	12	,	,	PUNCT
admet-1513	1028	13	y.	y.	PROPN
admet-1513	1028	14	zavros	zavros	PROPN
admet-1513	1028	15	,	,	PUNCT
admet-1513	1028	16	j.r	j.r	PROPN
admet-1513	1028	17	.	.	PROPN
admet-1513	1028	18	spence	spence	PROPN
admet-1513	1028	19	.	.	PUNCT
admet-1513	1029	1	organoid	organoid	PROPN
admet-1513	1029	2	models	model	NOUN
admet-1513	1029	3	of	of	ADP
admet-1513	1029	4	human	human	ADJ
admet-1513	1029	5	gastrointestinal	gastrointestinal	ADJ
admet-1513	1029	6	development	development	NOUN
admet-1513	1029	7	and	and	CCONJ
admet-1513	1029	8	disease	disease	NOUN
admet-1513	1029	9	.	.	PUNCT
admet-1513	1030	1	gastroenterology	gastroenterology	NOUN
admet-1513	1030	2	150	150	NUM
admet-1513	1030	3	(	(	PUNCT
admet-1513	1030	4	2016	2016	NUM
admet-1513	1030	5	)	)	PUNCT
admet-1513	1030	6	1098	1098	NUM
admet-1513	1030	7	-	-	SYM
admet-1513	1030	8	1112	1112	NUM
admet-1513	1030	9	.	.	PUNCT
admet-1513	1031	1	https://doi.org/10.1053/j.gastro.2015.12.042	https://doi.org/10.1053/j.gastro.2015.12.042	NOUN
admet-1513	1031	2	.	.	PUNCT
admet-1513	1032	1	[	[	X
admet-1513	1032	2	99	99	NUM
admet-1513	1032	3	]	]	PUNCT
admet-1513	1032	4	m.	m.	NOUN
admet-1513	1032	5	kim	kim	PROPN
admet-1513	1032	6	,	,	PUNCT
admet-1513	1032	7	h.	h.	PROPN
admet-1513	1032	8	mun	mun	PROPN
admet-1513	1032	9	,	,	PUNCT
admet-1513	1032	10	c.o	c.o	PROPN
admet-1513	1032	11	.	.	PROPN
admet-1513	1032	12	sung	sung	PROPN
admet-1513	1032	13	,	,	PUNCT
admet-1513	1032	14	e.j	e.j	PROPN
admet-1513	1032	15	.	.	PROPN
admet-1513	1032	16	cho	cho	PROPN
admet-1513	1032	17	,	,	PUNCT
admet-1513	1032	18	h.j	h.j	PROPN
admet-1513	1032	19	.	.	PROPN
admet-1513	1032	20	jeon	jeon	PROPN
admet-1513	1032	21	,	,	PUNCT
admet-1513	1032	22	s.m	s.m	PROPN
admet-1513	1032	23	.	.	PROPN
admet-1513	1032	24	chun	chun	PROPN
admet-1513	1032	25	,	,	PUNCT
admet-1513	1032	26	d.j	d.j	PROPN
admet-1513	1032	27	.	.	PROPN
admet-1513	1032	28	jung	jung	PROPN
admet-1513	1032	29	,	,	PUNCT
admet-1513	1032	30	t.h	t.h	PROPN
admet-1513	1032	31	.	.	PROPN
admet-1513	1032	32	shin	shin	PROPN
admet-1513	1032	33	,	,	PUNCT
admet-1513	1032	34	g.s	g.s	PROPN
admet-1513	1032	35	.	.	PROPN
admet-1513	1032	36	jeong	jeong	PROPN
admet-1513	1032	37	,	,	PUNCT
admet-1513	1032	38	d.k	d.k	PROPN
admet-1513	1032	39	.	.	PROPN
admet-1513	1033	1	kim	kim	PROPN
admet-1513	1033	2	,	,	PUNCT
admet-1513	1033	3	e.k	e.k	PROPN
admet-1513	1033	4	.	.	PROPN
admet-1513	1033	5	choi	choi	PROPN
admet-1513	1033	6	,	,	PUNCT
admet-1513	1033	7	s.y	s.y	PROPN
admet-1513	1033	8	.	.	PROPN
admet-1513	1033	9	jeong	jeong	PROPN
admet-1513	1033	10	,	,	PUNCT
admet-1513	1033	11	a.m.	a.m.	PROPN
admet-1513	1033	12	taylor	taylor	PROPN
admet-1513	1033	13	,	,	PUNCT
admet-1513	1033	14	s.	s.	PROPN
admet-1513	1033	15	jain	jain	PROPN
admet-1513	1033	16	,	,	PUNCT
admet-1513	1033	17	m.	m.	NOUN
admet-1513	1033	18	meyerson	meyerson	PROPN
admet-1513	1033	19	,	,	PUNCT
admet-1513	1033	20	s.j	s.j	PROPN
admet-1513	1033	21	.	.	PROPN
admet-1513	1033	22	jang	jang	PROPN
admet-1513	1033	23	.	.	PUNCT
admet-1513	1034	1	patient	patient	NOUN
admet-1513	1034	2	-	-	PUNCT
admet-1513	1034	3	derived	derive	VERB
admet-1513	1034	4	lung	lung	NOUN
admet-1513	1034	5	cancer	cancer	NOUN
admet-1513	1034	6	organoids	organoid	NOUN
admet-1513	1034	7	as	as	ADP
admet-1513	1034	8	in	in	ADP
admet-1513	1034	9	vitro	vitro	X
admet-1513	1034	10	cancer	cancer	NOUN
admet-1513	1034	11	models	model	NOUN
admet-1513	1034	12	for	for	ADP
admet-1513	1034	13	therapeutic	therapeutic	ADJ
admet-1513	1034	14	screening	screening	NOUN
admet-1513	1034	15	.	.	PUNCT
admet-1513	1035	1	nat	nat	PROPN
admet-1513	1035	2	.	.	PUNCT
admet-1513	1036	1	commun	commun	PROPN
admet-1513	1036	2	.	.	PUNCT
admet-1513	1037	1	10	10	NUM
admet-1513	1037	2	(	(	PUNCT
admet-1513	1037	3	2019	2019	NUM
admet-1513	1037	4	)	)	PUNCT
admet-1513	1037	5	3991	3991	NUM
admet-1513	1037	6	.	.	PUNCT
admet-1513	1038	1	https://doi.org/10.1038/s41467-019-11867-6	https://doi.org/10.1038/s41467-019-11867-6	NUM
admet-1513	1038	2	.	.	PUNCT
admet-1513	1039	1	[	[	X
admet-1513	1039	2	100	100	NUM
admet-1513	1039	3	]	]	PUNCT
admet-1513	1039	4	k.	k.	PROPN
admet-1513	1039	5	takayama	takayama	PROPN
admet-1513	1039	6	,	,	PUNCT
admet-1513	1039	7	y.	y.	PROPN
admet-1513	1039	8	morisaki	morisaki	PROPN
admet-1513	1039	9	,	,	PUNCT
admet-1513	1039	10	s.	s.	PROPN
admet-1513	1039	11	kuno	kuno	PROPN
admet-1513	1039	12	,	,	PUNCT
admet-1513	1039	13	y.	y.	PROPN
admet-1513	1039	14	nagamoto	nagamoto	PROPN
admet-1513	1039	15	,	,	PUNCT
admet-1513	1039	16	k.	k.	PROPN
admet-1513	1039	17	harada	harada	PROPN
admet-1513	1039	18	,	,	PUNCT
admet-1513	1039	19	n.	n.	PROPN
admet-1513	1039	20	furukawa	furukawa	PROPN
admet-1513	1039	21	,	,	PUNCT
admet-1513	1039	22	m.	m.	NOUN
admet-1513	1039	23	ohtaka	ohtaka	NOUN
admet-1513	1039	24	,	,	PUNCT
admet-1513	1039	25	k.	k.	PROPN
admet-1513	1039	26	nishimura	nishimura	PROPN
admet-1513	1039	27	,	,	PUNCT
admet-1513	1039	28	k.	k.	PROPN
admet-1513	1039	29	imagawa	imagawa	PROPN
admet-1513	1039	30	,	,	PUNCT
admet-1513	1039	31	f.	f.	PROPN
admet-1513	1039	32	sakurai	sakurai	PROPN
admet-1513	1039	33	,	,	PUNCT
admet-1513	1039	34	m.	m.	NOUN
admet-1513	1039	35	tachibana	tachibana	PROPN
admet-1513	1039	36	,	,	PUNCT
admet-1513	1039	37	r.	r.	PROPN
admet-1513	1039	38	sumazaki	sumazaki	PROPN
admet-1513	1039	39	,	,	PUNCT
admet-1513	1039	40	e.	e.	PROPN
admet-1513	1039	41	noguchi	noguchi	PROPN
admet-1513	1039	42	,	,	PUNCT
admet-1513	1039	43	m.	m.	PROPN
admet-1513	1039	44	nakanishi	nakanishi	PROPN
admet-1513	1039	45	,	,	PUNCT
admet-1513	1039	46	k.	k.	PROPN
admet-1513	1039	47	hirata	hirata	PROPN
admet-1513	1039	48	,	,	PUNCT
admet-1513	1039	49	k.	k.	PROPN
admet-1513	1039	50	kawabata	kawabata	PROPN
admet-1513	1039	51	,	,	PUNCT
admet-1513	1039	52	h.	h.	PROPN
admet-1513	1039	53	mizuguchi	mizuguchi	PROPN
admet-1513	1039	54	.	.	PUNCT
admet-1513	1040	1	prediction	prediction	NOUN
admet-1513	1040	2	of	of	ADP
admet-1513	1040	3	interindividual	interindividual	ADJ
admet-1513	1040	4	differences	difference	NOUN
admet-1513	1040	5	in	in	ADP
admet-1513	1040	6	hepatic	hepatic	ADJ
admet-1513	1040	7	functions	function	NOUN
admet-1513	1040	8	and	and	CCONJ
admet-1513	1040	9	drug	drug	NOUN
admet-1513	1040	10	sensitivity	sensitivity	NOUN
admet-1513	1040	11	by	by	ADP
admet-1513	1040	12	using	use	VERB
admet-1513	1040	13	human	human	ADJ
admet-1513	1040	14	ips	ip	NOUN
admet-1513	1040	15	-	-	PUNCT
admet-1513	1040	16	derived	derive	VERB
admet-1513	1040	17	hepatocytes	hepatocyte	NOUN
admet-1513	1040	18	.	.	PUNCT
admet-1513	1041	1	proc	proc	PROPN
admet-1513	1041	2	.	.	PUNCT
admet-1513	1042	1	natl	natl	PROPN
admet-1513	1042	2	.	.	PUNCT
admet-1513	1043	1	acad	acad	PROPN
admet-1513	1043	2	.	.	PUNCT
admet-1513	1044	1	sci	sci	PROPN
admet-1513	1044	2	.	.	PROPN
admet-1513	1044	3	usa	usa	PROPN
admet-1513	1044	4	111	111	NUM
admet-1513	1044	5	(	(	PUNCT
admet-1513	1044	6	2014	2014	NUM
admet-1513	1044	7	)	)	PUNCT
admet-1513	1044	8	16772	16772	NUM
admet-1513	1044	9	-	-	SYM
admet-1513	1044	10	16777	16777	NUM
admet-1513	1044	11	.	.	PUNCT
admet-1513	1045	1	https://doi.org/10.1073/pnas.1413481111	https://doi.org/10.1073/pnas.1413481111	NOUN
admet-1513	1045	2	.	.	PUNCT
admet-1513	1046	1	[	[	X
admet-1513	1046	2	101	101	NUM
admet-1513	1046	3	]	]	X
admet-1513	1046	4	j.r	j.r	PROPN
admet-1513	1046	5	.	.	PROPN
admet-1513	1046	6	spence	spence	PROPN
admet-1513	1046	7	,	,	PUNCT
admet-1513	1046	8	c.n	c.n	PROPN
admet-1513	1046	9	.	.	PROPN
admet-1513	1046	10	mayhew	mayhew	PROPN
admet-1513	1046	11	,	,	PUNCT
admet-1513	1046	12	s.a	s.a	PROPN
admet-1513	1046	13	.	.	PROPN
admet-1513	1046	14	rankin	rankin	PROPN
admet-1513	1046	15	,	,	PUNCT
admet-1513	1046	16	m.f	m.f	PROPN
admet-1513	1046	17	.	.	PROPN
admet-1513	1046	18	kuhar	kuhar	PROPN
admet-1513	1046	19	,	,	PUNCT
admet-1513	1046	20	j.e	j.e	PROPN
admet-1513	1046	21	.	.	PROPN
admet-1513	1046	22	vallance	vallance	PROPN
admet-1513	1046	23	,	,	PUNCT
admet-1513	1046	24	k.	k.	PROPN
admet-1513	1046	25	tolle	tolle	PROPN
admet-1513	1046	26	,	,	PUNCT
admet-1513	1046	27	e.e	e.e	PROPN
admet-1513	1046	28	.	.	PROPN
admet-1513	1046	29	hoskins	hoskins	PROPN
admet-1513	1046	30	,	,	PUNCT
admet-1513	1046	31	v.v	v.v	PROPN
admet-1513	1046	32	.	.	PROPN
admet-1513	1046	33	kalinichenko	kalinichenko	PROPN
admet-1513	1046	34	,	,	PUNCT
admet-1513	1046	35	s.i	s.i	PROPN
admet-1513	1046	36	.	.	PROPN
admet-1513	1046	37	wells	wells	PROPN
admet-1513	1046	38	,	,	PUNCT
admet-1513	1046	39	a.m.	a.m.	PROPN
admet-1513	1046	40	zorn	zorn	PROPN
admet-1513	1046	41	,	,	PUNCT
admet-1513	1046	42	n.f	n.f	PROPN
admet-1513	1046	43	.	.	PROPN
admet-1513	1046	44	shroyer	shroyer	PROPN
admet-1513	1046	45	,	,	PUNCT
admet-1513	1046	46	j.m	j.m	PROPN
admet-1513	1046	47	.	.	PROPN
admet-1513	1046	48	wells	wells	PROPN
admet-1513	1046	49	.	.	PUNCT
admet-1513	1047	1	directed	direct	VERB
admet-1513	1047	2	differentiation	differentiation	NOUN
admet-1513	1047	3	of	of	ADP
admet-1513	1047	4	human	human	ADJ
admet-1513	1047	5	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	1047	6	https://doi.org/10.1007/978-981-13-7647-4_6	https://doi.org/10.1007/978-981-13-7647-4_6	PROPN
admet-1513	1047	7	https://doi.org/10.1124/dmd.106.014241	https://doi.org/10.1124/dmd.106.014241	PROPN
admet-1513	1047	8	https://doi.org/10.1124/dmd.106.014241	https://doi.org/10.1124/dmd.106.014241	PROPN
admet-1513	1047	9	https://doi.org/10.1016/s0006-2952(99)00139-2	https://doi.org/10.1016/s0006-2952(99)00139-2	PROPN
admet-1513	1047	10	https://doi.org/10.1007/978-981-13-7647-4_4	https://doi.org/10.1007/978-981-13-7647-4_4	PROPN
admet-1513	1048	1	https://doi.org/10.1099/0022-1317-36-1-59	https://doi.org/10.1099/0022-1317-36-1-59	PROPN
admet-1513	1048	2	https://doi.org/10.1099/0022-1317-36-1-59	https://doi.org/10.1099/0022-1317-36-1-59	PROPN
admet-1513	1048	3	https://doi.org/10.1124/dmd.107.014902	https://doi.org/10.1124/dmd.107.014902	VERB
admet-1513	1048	4	https://doi.org/10.1128/aac.02765-15	https://doi.org/10.1128/aac.02765-15	INTJ
admet-1513	1048	5	https://doi.org/10.1128/aac.02765-15	https://doi.org/10.1128/aac.02765-15	PROPN
admet-1513	1048	6	https://doi.org/10.1038/nrd.2016.184	https://doi.org/10.1038/nrd.2016.184	VERB
admet-1513	1048	7	https://doi.org/10.1126/science.aaw6985	https://doi.org/10.1126/science.aaw6985	PROPN
admet-1513	1048	8	https://doi.org/10.1038/nrm2236	https://doi.org/10.1038/nrm2236	VERB
admet-1513	1048	9	https://doi.org/10.5772/intechopen.81552	https://doi.org/10.5772/intechopen.81552	ADJ
admet-1513	1048	10	https://doi.org/10.1053/j.gastro.2015.12.042	https://doi.org/10.1053/j.gastro.2015.12.042	PROPN
admet-1513	1048	11	https://doi.org/10.1053/j.gastro.2015.12.042	https://doi.org/10.1053/j.gastro.2015.12.042	VERB
admet-1513	1048	12	https://doi.org/10.1038/s41467-019-11867-6	https://doi.org/10.1038/s41467-019-11867-6	NUM
admet-1513	1048	13	https://doi.org/10.1073/pnas.1413481111	https://doi.org/10.1073/pnas.1413481111	NOUN
admet-1513	1048	14	https://doi.org/10.1073/pnas.1413481111	https://doi.org/10.1073/pnas.1413481111	X
admet-1513	1048	15	venkatesh	venkatesh	PROPN
admet-1513	1048	16	chunduri	chunduri	PROPN
admet-1513	1048	17	and	and	CCONJ
admet-1513	1048	18	srinivas	srinivas	PROPN
admet-1513	1048	19	maddi	maddi	PROPN
admet-1513	1048	20	admet	admet	PROPN
admet-1513	1048	21	&	&	CCONJ
admet-1513	1048	22	dmpk	dmpk	PROPN
admet-1513	1048	23	11(1	11(1	NUM
admet-1513	1048	24	)	)	PUNCT
admet-1513	1048	25	(	(	PUNCT
admet-1513	1048	26	2023	2023	NUM
admet-1513	1048	27	)	)	PUNCT
admet-1513	1048	28	1	1	NUM
admet-1513	1048	29	-	-	SYM
admet-1513	1048	30	32	32	NUM
admet-1513	1048	31	24	24	NUM
admet-1513	1048	32	pluripotent	pluripotent	ADJ
admet-1513	1048	33	stem	stem	NOUN
admet-1513	1048	34	cells	cell	NOUN
admet-1513	1048	35	into	into	ADP
admet-1513	1048	36	intestinal	intestinal	ADJ
admet-1513	1048	37	tissue	tissue	NOUN
admet-1513	1048	38	in	in	ADP
admet-1513	1048	39	vitro	vitro	X
admet-1513	1048	40	.	.	PUNCT
admet-1513	1049	1	nature	nature	NOUN
admet-1513	1049	2	470	470	NUM
admet-1513	1049	3	(	(	PUNCT
admet-1513	1049	4	2011	2011	NUM
admet-1513	1049	5	)	)	PUNCT
admet-1513	1049	6	105	105	NUM
admet-1513	1049	7	-	-	SYM
admet-1513	1049	8	109	109	NUM
admet-1513	1049	9	.	.	PUNCT
admet-1513	1049	10	https://doi.org/10.1038/nature09691	https://doi.org/10.1038/nature09691	PROPN
admet-1513	1049	11	.	.	PUNCT
admet-1513	1050	1	[	[	X
admet-1513	1050	2	102	102	NUM
admet-1513	1050	3	]	]	X
admet-1513	1050	4	s.	s.	PROPN
admet-1513	1050	5	ogaki	ogaki	PROPN
admet-1513	1050	6	,	,	PUNCT
admet-1513	1050	7	n.	n.	PROPN
admet-1513	1050	8	shiraki	shiraki	PROPN
admet-1513	1050	9	,	,	PUNCT
admet-1513	1050	10	k.	k.	PROPN
admet-1513	1050	11	kume	kume	PROPN
admet-1513	1050	12	,	,	PUNCT
admet-1513	1050	13	s.	s.	PROPN
admet-1513	1050	14	kume	kume	PROPN
admet-1513	1050	15	.	.	PUNCT
admet-1513	1050	16	wnt	wnt	NOUN
admet-1513	1050	17	and	and	CCONJ
admet-1513	1050	18	notch	notch	ADJ
admet-1513	1050	19	signals	signal	NOUN
admet-1513	1050	20	guide	guide	NOUN
admet-1513	1050	21	embryonic	embryonic	ADJ
admet-1513	1050	22	stem	stem	NOUN
admet-1513	1050	23	cell	cell	NOUN
admet-1513	1050	24	differentiation	differentiation	NOUN
admet-1513	1050	25	into	into	ADP
admet-1513	1050	26	the	the	DET
admet-1513	1050	27	intestinal	intestinal	ADJ
admet-1513	1050	28	lineages	lineage	NOUN
admet-1513	1050	29	.	.	PUNCT
admet-1513	1051	1	stem	stem	NOUN
admet-1513	1051	2	cells	cell	NOUN
admet-1513	1051	3	31	31	NUM
admet-1513	1051	4	(	(	PUNCT
admet-1513	1051	5	2013	2013	NUM
admet-1513	1051	6	)	)	PUNCT
admet-1513	1051	7	1086	1086	NUM
admet-1513	1051	8	-	-	SYM
admet-1513	1051	9	1096	1096	NUM
admet-1513	1051	10	.	.	PUNCT
admet-1513	1052	1	https://doi.org/10.1002/stem.1344	https://doi.org/10.1002/stem.1344	NOUN
admet-1513	1052	2	.	.	PUNCT
admet-1513	1053	1	[	[	X
admet-1513	1053	2	103	103	NUM
admet-1513	1053	3	]	]	X
admet-1513	1053	4	k.w	k.w	PROPN
admet-1513	1053	5	.	.	PROPN
admet-1513	1053	6	mccracken	mccracken	PROPN
admet-1513	1053	7	,	,	PUNCT
admet-1513	1053	8	e.m	e.m	PROPN
admet-1513	1053	9	.	.	PROPN
admet-1513	1053	10	catá	catá	PROPN
admet-1513	1053	11	,	,	PUNCT
admet-1513	1053	12	c.m	c.m	PROPN
admet-1513	1053	13	.	.	PROPN
admet-1513	1053	14	crawford	crawford	PROPN
admet-1513	1053	15	,	,	PUNCT
admet-1513	1053	16	k.l	k.l	PROPN
admet-1513	1053	17	.	.	PROPN
admet-1513	1053	18	sinagoga	sinagoga	NOUN
admet-1513	1053	19	,	,	PUNCT
admet-1513	1053	20	m.	m.	NOUN
admet-1513	1053	21	schumacher	schumacher	PROPN
admet-1513	1053	22	,	,	PUNCT
admet-1513	1053	23	b.e	b.e	PROPN
admet-1513	1053	24	.	.	PROPN
admet-1513	1053	25	rockich	rockich	PROPN
admet-1513	1053	26	,	,	PUNCT
admet-1513	1053	27	y.h	y.h	PROPN
admet-1513	1053	28	.	.	PROPN
admet-1513	1053	29	tsai	tsai	PROPN
admet-1513	1053	30	,	,	PUNCT
admet-1513	1053	31	c.n	c.n	PROPN
admet-1513	1053	32	.	.	PROPN
admet-1513	1053	33	mayhew	mayhew	PROPN
admet-1513	1053	34	,	,	PUNCT
admet-1513	1053	35	j.r	j.r	PROPN
admet-1513	1053	36	.	.	PROPN
admet-1513	1053	37	spence	spence	PROPN
admet-1513	1053	38	,	,	PUNCT
admet-1513	1053	39	y.	y.	PROPN
admet-1513	1053	40	zavros	zavros	PROPN
admet-1513	1053	41	,	,	PUNCT
admet-1513	1053	42	j.m	j.m	PROPN
admet-1513	1053	43	.	.	PROPN
admet-1513	1053	44	wells	wells	PROPN
admet-1513	1053	45	.	.	PUNCT
admet-1513	1054	1	modelling	model	VERB
admet-1513	1054	2	human	human	ADJ
admet-1513	1054	3	development	development	NOUN
admet-1513	1054	4	and	and	CCONJ
admet-1513	1054	5	disease	disease	NOUN
admet-1513	1054	6	in	in	ADP
admet-1513	1054	7	pluripotent	pluripotent	ADJ
admet-1513	1054	8	stem	stem	NOUN
admet-1513	1054	9	-	-	PUNCT
admet-1513	1054	10	cell	cell	NOUN
admet-1513	1054	11	-	-	PUNCT
admet-1513	1054	12	derived	derive	VERB
admet-1513	1054	13	gastric	gastric	ADJ
admet-1513	1054	14	organoids	organoid	NOUN
admet-1513	1054	15	.	.	PUNCT
admet-1513	1055	1	nature	nature	NOUN
admet-1513	1055	2	516	516	NUM
admet-1513	1055	3	(	(	PUNCT
admet-1513	1055	4	2014	2014	NUM
admet-1513	1055	5	)	)	PUNCT
admet-1513	1055	6	400	400	NUM
admet-1513	1055	7	-	-	SYM
admet-1513	1055	8	404	404	NUM
admet-1513	1055	9	.	.	PUNCT
admet-1513	1056	1	https://doi.org/10.1038/nature13863	https://doi.org/10.1038/nature13863	PROPN
admet-1513	1056	2	.	.	PUNCT
admet-1513	1057	1	[	[	X
admet-1513	1057	2	104	104	NUM
admet-1513	1057	3	]	]	X
admet-1513	1057	4	c.	c.	PROPN
admet-1513	1057	5	greggio	greggio	PROPN
admet-1513	1057	6	,	,	PUNCT
admet-1513	1057	7	f.	f.	PROPN
admet-1513	1057	8	de	de	PROPN
admet-1513	1057	9	franceschi	franceschi	PROPN
admet-1513	1057	10	,	,	PUNCT
admet-1513	1057	11	m.	m.	NOUN
admet-1513	1057	12	figueiredo	figueiredo	PROPN
admet-1513	1057	13	-	-	PUNCT
admet-1513	1057	14	larsen	larsen	PROPN
admet-1513	1057	15	,	,	PUNCT
admet-1513	1057	16	s.	s.	PROPN
admet-1513	1057	17	gobaa	gobaa	PROPN
admet-1513	1057	18	,	,	PUNCT
admet-1513	1057	19	a.	a.	NOUN
admet-1513	1057	20	ranga	ranga	PROPN
admet-1513	1057	21	,	,	PUNCT
admet-1513	1057	22	h.	h.	PROPN
admet-1513	1057	23	semb	semb	PROPN
admet-1513	1057	24	,	,	PUNCT
admet-1513	1057	25	m.	m.	NOUN
admet-1513	1057	26	lutolf	lutolf	PROPN
admet-1513	1057	27	,	,	PUNCT
admet-1513	1057	28	a.	a.	PROPN
admet-1513	1057	29	grapinbotton	grapinbotton	PROPN
admet-1513	1057	30	.	.	PUNCT
admet-1513	1058	1	artificial	artificial	ADJ
admet-1513	1058	2	three	three	NUM
admet-1513	1058	3	-	-	PUNCT
admet-1513	1058	4	dimensional	dimensional	ADJ
admet-1513	1058	5	niches	niche	NOUN
admet-1513	1058	6	deconstruct	deconstruct	VERB
admet-1513	1058	7	pancreas	pancreas	NOUN
admet-1513	1058	8	development	development	NOUN
admet-1513	1058	9	in	in	ADP
admet-1513	1058	10	vitro	vitro	X
admet-1513	1058	11	.	.	PUNCT
admet-1513	1059	1	development	development	NOUN
admet-1513	1059	2	140	140	NUM
admet-1513	1059	3	(	(	PUNCT
admet-1513	1059	4	2013	2013	NUM
admet-1513	1059	5	)	)	PUNCT
admet-1513	1059	6	4452	4452	NUM
admet-1513	1059	7	-	-	SYM
admet-1513	1059	8	4462	4462	NUM
admet-1513	1059	9	.	.	PUNCT
admet-1513	1060	1	https://doi.org/10.1242/dev.096628	https://doi.org/10.1242/dev.096628	PROPN
admet-1513	1060	2	.	.	PUNCT
admet-1513	1061	1	[	[	X
admet-1513	1061	2	105	105	NUM
admet-1513	1061	3	]	]	PUNCT
admet-1513	1061	4	m.	m.	NOUN
admet-1513	1061	5	fujii	fujii	PROPN
admet-1513	1061	6	,	,	PUNCT
admet-1513	1061	7	m.	m.	PROPN
admet-1513	1061	8	matano	matano	PROPN
admet-1513	1061	9	,	,	PUNCT
admet-1513	1061	10	k.	k.	PROPN
admet-1513	1061	11	toshimitsu	toshimitsu	PROPN
admet-1513	1061	12	,	,	PUNCT
admet-1513	1061	13	a.	a.	PROPN
admet-1513	1061	14	takano	takano	PROPN
admet-1513	1061	15	,	,	PUNCT
admet-1513	1061	16	y.	y.	PROPN
admet-1513	1061	17	mikami	mikami	PROPN
admet-1513	1061	18	,	,	PUNCT
admet-1513	1061	19	s.	s.	PROPN
admet-1513	1061	20	nishikori	nishikori	PROPN
admet-1513	1061	21	,	,	PUNCT
admet-1513	1061	22	s.	s.	PROPN
admet-1513	1061	23	sugimoto	sugimoto	PROPN
admet-1513	1061	24	,	,	PUNCT
admet-1513	1061	25	t.	t.	PROPN
admet-1513	1061	26	sato	sato	PROPN
admet-1513	1061	27	.	.	PUNCT
admet-1513	1062	1	human	human	ADJ
admet-1513	1062	2	intestinal	intestinal	ADJ
admet-1513	1062	3	organoids	organoid	NOUN
admet-1513	1062	4	maintain	maintain	VERB
admet-1513	1062	5	self	self	NOUN
admet-1513	1062	6	-	-	PUNCT
admet-1513	1062	7	renewal	renewal	NOUN
admet-1513	1062	8	capacity	capacity	NOUN
admet-1513	1062	9	and	and	CCONJ
admet-1513	1062	10	cellular	cellular	ADJ
admet-1513	1062	11	diversity	diversity	NOUN
admet-1513	1062	12	in	in	ADP
admet-1513	1062	13	niche	niche	NOUN
admet-1513	1062	14	-	-	PUNCT
admet-1513	1062	15	inspired	inspire	VERB
admet-1513	1062	16	culture	culture	NOUN
admet-1513	1062	17	condition	condition	NOUN
admet-1513	1062	18	.	.	PUNCT
admet-1513	1063	1	cell	cell	NOUN
admet-1513	1063	2	stem	stem	NOUN
admet-1513	1063	3	cell	cell	NOUN
admet-1513	1063	4	23	23	NUM
admet-1513	1063	5	(	(	PUNCT
admet-1513	1063	6	2018	2018	NUM
admet-1513	1063	7	)	)	PUNCT
admet-1513	1063	8	787	787	NUM
admet-1513	1063	9	-	-	PUNCT
admet-1513	1063	10	793.e6	793.e6	NUM
admet-1513	1063	11	.	.	PUNCT
admet-1513	1064	1	https://doi.org/10.1016/j.stem.2018.11.016	https://doi.org/10.1016/j.stem.2018.11.016	NOUN
admet-1513	1064	2	.	.	PUNCT
admet-1513	1065	1	[	[	X
admet-1513	1065	2	106	106	X
admet-1513	1065	3	]	]	X
admet-1513	1065	4	s.	s.	PROPN
admet-1513	1065	5	yoshida	yoshida	PROPN
admet-1513	1065	6	,	,	PUNCT
admet-1513	1065	7	h.	h.	PROPN
admet-1513	1065	8	miwa	miwa	PROPN
admet-1513	1065	9	,	,	PUNCT
admet-1513	1065	10	t.	t.	PROPN
admet-1513	1065	11	kawachi	kawachi	PROPN
admet-1513	1065	12	,	,	PUNCT
admet-1513	1065	13	s.	s.	PROPN
admet-1513	1065	14	kume	kume	PROPN
admet-1513	1065	15	,	,	PUNCT
admet-1513	1065	16	k.	k.	PROPN
admet-1513	1065	17	takahashi	takahashi	PROPN
admet-1513	1065	18	.	.	PUNCT
admet-1513	1066	1	generation	generation	NOUN
admet-1513	1066	2	of	of	ADP
admet-1513	1066	3	intestinal	intestinal	ADJ
admet-1513	1066	4	organoids	organoid	NOUN
admet-1513	1066	5	derived	derive	VERB
admet-1513	1066	6	from	from	ADP
admet-1513	1066	7	human	human	ADJ
admet-1513	1066	8	pluripotent	pluripotent	NOUN
admet-1513	1066	9	stem	stem	NOUN
admet-1513	1066	10	cells	cell	NOUN
admet-1513	1066	11	for	for	ADP
admet-1513	1066	12	drug	drug	NOUN
admet-1513	1066	13	testing	testing	NOUN
admet-1513	1066	14	.	.	PUNCT
admet-1513	1067	1	sci	sci	PROPN
admet-1513	1067	2	.	.	PROPN
admet-1513	1067	3	rep	rep	PROPN
admet-1513	1067	4	.	.	PROPN
admet-1513	1067	5	10	10	NUM
admet-1513	1067	6	(	(	PUNCT
admet-1513	1067	7	2020	2020	NUM
admet-1513	1067	8	)	)	PUNCT
admet-1513	1067	9	5989	5989	NUM
admet-1513	1067	10	.	.	PUNCT
admet-1513	1068	1	https://doi.org/10.1038/s41598-020-63151-z	https://doi.org/10.1038/s41598-020-63151-z	NOUN
admet-1513	1068	2	.	.	PUNCT
admet-1513	1069	1	[	[	X
admet-1513	1069	2	107	107	X
admet-1513	1069	3	]	]	PUNCT
admet-1513	1069	4	j.	j.	PROPN
admet-1513	1069	5	markus	markus	PROPN
admet-1513	1069	6	,	,	PUNCT
admet-1513	1069	7	t.	t.	PROPN
admet-1513	1069	8	landry	landry	PROPN
admet-1513	1069	9	,	,	PUNCT
admet-1513	1069	10	z.	z.	PROPN
admet-1513	1069	11	stevens	stevens	PROPN
admet-1513	1069	12	,	,	PUNCT
admet-1513	1069	13	h.	h.	PROPN
admet-1513	1069	14	scott	scott	PROPN
admet-1513	1069	15	,	,	PUNCT
admet-1513	1069	16	p.	p.	PROPN
admet-1513	1069	17	llanos	llanos	PROPN
admet-1513	1069	18	,	,	PUNCT
admet-1513	1069	19	m.	m.	NOUN
admet-1513	1069	20	debatis	debatis	PROPN
admet-1513	1069	21	,	,	PUNCT
admet-1513	1069	22	a.	a.	NOUN
admet-1513	1069	23	armento	armento	PROPN
admet-1513	1069	24	,	,	PUNCT
admet-1513	1069	25	m.	m.	PROPN
admet-1513	1069	26	klausner	klausner	PROPN
admet-1513	1069	27	,	,	PUNCT
admet-1513	1069	28	s.	s.	PROPN
admet-1513	1069	29	ayehunie	ayehunie	PROPN
admet-1513	1069	30	.	.	PUNCT
admet-1513	1070	1	human	human	ADJ
admet-1513	1070	2	small	small	ADJ
admet-1513	1070	3	intestinal	intestinal	ADJ
admet-1513	1070	4	organotypic	organotypic	ADJ
admet-1513	1070	5	culture	culture	NOUN
admet-1513	1070	6	model	model	NOUN
admet-1513	1070	7	for	for	ADP
admet-1513	1070	8	drug	drug	NOUN
admet-1513	1070	9	permeation	permeation	NOUN
admet-1513	1070	10	,	,	PUNCT
admet-1513	1070	11	inflammation	inflammation	NOUN
admet-1513	1070	12	,	,	PUNCT
admet-1513	1070	13	and	and	CCONJ
admet-1513	1070	14	toxicity	toxicity	NOUN
admet-1513	1070	15	assays	assay	NOUN
admet-1513	1070	16	.	.	PUNCT
admet-1513	1071	1	in	in	ADP
admet-1513	1071	2	vitro	vitro	X
admet-1513	1071	3	cell	cell	PROPN
admet-1513	1071	4	dev	dev	PROPN
admet-1513	1071	5	.	.	PUNCT
admet-1513	1072	1	biol	biol	PROPN
admet-1513	1072	2	.	.	PUNCT
admet-1513	1073	1	anim	anim	NOUN
admet-1513	1073	2	.	.	PUNCT
admet-1513	1074	1	57	57	NUM
admet-1513	1074	2	(	(	PUNCT
admet-1513	1074	3	2021	2021	NUM
admet-1513	1074	4	)	)	PUNCT
admet-1513	1074	5	160	160	NUM
admet-1513	1074	6	-	-	SYM
admet-1513	1074	7	173	173	NUM
admet-1513	1074	8	.	.	PUNCT
admet-1513	1075	1	https://doi.org/10.1007/s11626-020-005266	https://doi.org/10.1007/s11626-020-005266	NOUN
admet-1513	1075	2	.	.	PUNCT
admet-1513	1076	1	[	[	X
admet-1513	1076	2	108	108	NUM
admet-1513	1076	3	]	]	SYM
admet-1513	1076	4	k.a	k.a	PROPN
admet-1513	1076	5	.	.	PUNCT
admet-1513	1076	6	d'amour	d'amour	PROPN
admet-1513	1076	7	,	,	PUNCT
admet-1513	1076	8	a.d	a.d	PROPN
admet-1513	1076	9	.	.	PROPN
admet-1513	1076	10	agulnick	agulnick	PROPN
admet-1513	1076	11	,	,	PUNCT
admet-1513	1076	12	s.	s.	PROPN
admet-1513	1076	13	eliazer	eliazer	PROPN
admet-1513	1076	14	,	,	PUNCT
admet-1513	1076	15	o.g	o.g	PROPN
admet-1513	1076	16	.	.	PROPN
admet-1513	1076	17	kelly	kelly	PROPN
admet-1513	1076	18	,	,	PUNCT
admet-1513	1076	19	e.	e.	PROPN
admet-1513	1076	20	kroon	kroon	PROPN
admet-1513	1076	21	,	,	PUNCT
admet-1513	1076	22	e.e	e.e	PROPN
admet-1513	1076	23	.	.	PROPN
admet-1513	1076	24	baetge	baetge	VERB
admet-1513	1076	25	.	.	PUNCT
admet-1513	1077	1	efficient	efficient	ADJ
admet-1513	1077	2	differentiation	differentiation	NOUN
admet-1513	1077	3	of	of	ADP
admet-1513	1077	4	human	human	ADJ
admet-1513	1077	5	embryonic	embryonic	ADJ
admet-1513	1077	6	stem	stem	NOUN
admet-1513	1077	7	cells	cell	NOUN
admet-1513	1077	8	to	to	ADP
admet-1513	1077	9	definitive	definitive	ADJ
admet-1513	1077	10	endoderm	endoderm	NOUN
admet-1513	1077	11	.	.	PUNCT
admet-1513	1078	1	nat	nat	PROPN
admet-1513	1078	2	.	.	PUNCT
admet-1513	1079	1	biotechnol	biotechnol	PROPN
admet-1513	1079	2	.	.	PUNCT
admet-1513	1080	1	23	23	NUM
admet-1513	1080	2	(	(	PUNCT
admet-1513	1080	3	2005	2005	NUM
admet-1513	1080	4	)	)	PUNCT
admet-1513	1080	5	1534	1534	NUM
admet-1513	1080	6	-	-	SYM
admet-1513	1080	7	1541	1541	NUM
admet-1513	1080	8	.	.	PUNCT
admet-1513	1081	1	https://doi.org/10.1038/nbt1163	https://doi.org/10.1038/nbt1163	PROPN
admet-1513	1081	2	.	.	PUNCT
admet-1513	1082	1	[	[	X
admet-1513	1082	2	109	109	NUM
admet-1513	1082	3	]	]	PUNCT
admet-1513	1082	4	t.	t.	PROPN
admet-1513	1082	5	sato	sato	PROPN
admet-1513	1082	6	,	,	PUNCT
admet-1513	1082	7	j.h	j.h	PROPN
admet-1513	1082	8	.	.	PROPN
admet-1513	1082	9	van	van	PROPN
admet-1513	1082	10	es	es	PROPN
admet-1513	1082	11	,	,	PUNCT
admet-1513	1082	12	h.j	h.j	PROPN
admet-1513	1082	13	.	.	PROPN
admet-1513	1082	14	snippert	snippert	PROPN
admet-1513	1082	15	,	,	PUNCT
admet-1513	1082	16	d.e	d.e	PROPN
admet-1513	1082	17	.	.	PROPN
admet-1513	1082	18	stange	stange	PROPN
admet-1513	1082	19	,	,	PUNCT
admet-1513	1082	20	r.g	r.g	PROPN
admet-1513	1082	21	.	.	PROPN
admet-1513	1082	22	vries	vries	PROPN
admet-1513	1082	23	,	,	PUNCT
admet-1513	1082	24	m.	m.	PROPN
admet-1513	1082	25	van	van	PROPN
admet-1513	1082	26	den	den	PROPN
admet-1513	1082	27	born	bear	VERB
admet-1513	1082	28	,	,	PUNCT
admet-1513	1082	29	n.	n.	PROPN
admet-1513	1082	30	barker	barker	PROPN
admet-1513	1082	31	,	,	PUNCT
admet-1513	1082	32	n.f	n.f	PROPN
admet-1513	1082	33	.	.	PROPN
admet-1513	1082	34	shroyer	shroyer	PROPN
admet-1513	1082	35	,	,	PUNCT
admet-1513	1082	36	m.	m.	NOUN
admet-1513	1082	37	van	van	PROPN
admet-1513	1082	38	de	de	PROPN
admet-1513	1082	39	wetering	wetering	PROPN
admet-1513	1082	40	,	,	PUNCT
admet-1513	1082	41	h.	h.	PROPN
admet-1513	1082	42	clevers	clevers	PROPN
admet-1513	1082	43	.	.	PUNCT
admet-1513	1083	1	paneth	paneth	PROPN
admet-1513	1083	2	cells	cell	NOUN
admet-1513	1083	3	constitute	constitute	VERB
admet-1513	1083	4	the	the	DET
admet-1513	1083	5	niche	niche	NOUN
admet-1513	1083	6	for	for	ADP
admet-1513	1083	7	lgr5	lgr5	NOUN
admet-1513	1083	8	stem	stem	NOUN
admet-1513	1083	9	cells	cell	NOUN
admet-1513	1083	10	in	in	ADP
admet-1513	1083	11	intestinal	intestinal	ADJ
admet-1513	1083	12	crypts	crypt	NOUN
admet-1513	1083	13	.	.	PUNCT
admet-1513	1084	1	nature	nature	NOUN
admet-1513	1084	2	469	469	NUM
admet-1513	1084	3	(	(	PUNCT
admet-1513	1084	4	2011	2011	NUM
admet-1513	1084	5	)	)	PUNCT
admet-1513	1084	6	415	415	NUM
admet-1513	1084	7	-	-	SYM
admet-1513	1084	8	418	418	NUM
admet-1513	1084	9	.	.	PUNCT
admet-1513	1085	1	https://doi.org/10.1038/nature09637	https://doi.org/10.1038/nature09637	ADJ
admet-1513	1085	2	.	.	PUNCT
admet-1513	1086	1	[	[	X
admet-1513	1086	2	110	110	NUM
admet-1513	1086	3	]	]	X
admet-1513	1086	4	f.	f.	PROPN
admet-1513	1086	5	araújo	araújo	PROPN
admet-1513	1086	6	,	,	PUNCT
admet-1513	1086	7	b.	b.	PROPN
admet-1513	1086	8	sarmento	sarmento	PROPN
admet-1513	1086	9	.	.	PROPN
admet-1513	1087	1	towards	towards	ADP
admet-1513	1087	2	the	the	DET
admet-1513	1087	3	characterization	characterization	NOUN
admet-1513	1087	4	of	of	ADP
admet-1513	1087	5	an	an	DET
admet-1513	1087	6	in	in	NOUN
admet-1513	1087	7	vitro	vitro	X
admet-1513	1087	8	triple	triple	ADJ
admet-1513	1087	9	co	co	NOUN
admet-1513	1087	10	-	-	NOUN
admet-1513	1087	11	culture	culture	ADJ
admet-1513	1087	12	intestine	intestine	NOUN
admet-1513	1087	13	cell	cell	NOUN
admet-1513	1087	14	model	model	NOUN
admet-1513	1087	15	for	for	ADP
admet-1513	1087	16	permeability	permeability	NOUN
admet-1513	1087	17	studies	study	NOUN
admet-1513	1087	18	.	.	PUNCT
admet-1513	1088	1	int	int	NOUN
admet-1513	1088	2	.	.	PUNCT
admet-1513	1089	1	j.	j.	PROPN
admet-1513	1089	2	pharm	pharm	PROPN
admet-1513	1089	3	.	.	PUNCT
admet-1513	1090	1	458	458	NUM
admet-1513	1090	2	(	(	PUNCT
admet-1513	1090	3	2013	2013	NUM
admet-1513	1090	4	)	)	PUNCT
admet-1513	1090	5	128	128	NUM
admet-1513	1090	6	-	-	SYM
admet-1513	1090	7	134	134	NUM
admet-1513	1090	8	.	.	PUNCT
admet-1513	1091	1	https://doi.org/10.1016/j.ijpharm.2013.10.003	https://doi.org/10.1016/j.ijpharm.2013.10.003	X
admet-1513	1091	2	.	.	PUNCT
admet-1513	1092	1	[	[	X
admet-1513	1092	2	111	111	NUM
admet-1513	1092	3	]	]	PUNCT
admet-1513	1092	4	m.	m.	NOUN
admet-1513	1092	5	noben	noben	PROPN
admet-1513	1092	6	,	,	PUNCT
admet-1513	1092	7	b.	b.	PROPN
admet-1513	1092	8	verstockt	verstockt	PROPN
admet-1513	1092	9	,	,	PUNCT
admet-1513	1092	10	m.	m.	NOUN
admet-1513	1092	11	de	de	NOUN
admet-1513	1092	12	bruyn	bruyn	PROPN
admet-1513	1092	13	,	,	PUNCT
admet-1513	1092	14	n.	n.	PROPN
admet-1513	1092	15	hendriks	hendriks	PROPN
admet-1513	1092	16	,	,	PUNCT
admet-1513	1092	17	g.	g.	PROPN
admet-1513	1092	18	van	van	PROPN
admet-1513	1092	19	assche	assche	PROPN
admet-1513	1092	20	,	,	PUNCT
admet-1513	1092	21	s.	s.	PROPN
admet-1513	1092	22	vermeire	vermeire	PROPN
admet-1513	1092	23	,	,	PUNCT
admet-1513	1092	24	c.	c.	PROPN
admet-1513	1092	25	verfaillie	verfaillie	PROPN
admet-1513	1092	26	,	,	PUNCT
admet-1513	1092	27	m.	m.	PROPN
admet-1513	1092	28	ferrante	ferrante	PROPN
admet-1513	1092	29	.	.	PUNCT
admet-1513	1093	1	epithelial	epithelial	ADJ
admet-1513	1093	2	organoid	organoid	NOUN
admet-1513	1093	3	cultures	culture	NOUN
admet-1513	1093	4	from	from	ADP
admet-1513	1093	5	patients	patient	NOUN
admet-1513	1093	6	with	with	ADP
admet-1513	1093	7	ulcerative	ulcerative	ADJ
admet-1513	1093	8	colitis	colitis	NOUN
admet-1513	1093	9	and	and	CCONJ
admet-1513	1093	10	crohn	crohn	NOUN
admet-1513	1093	11	's	's	PART
admet-1513	1093	12	disease	disease	NOUN
admet-1513	1093	13	:	:	PUNCT
admet-1513	1093	14	a	a	DET
admet-1513	1093	15	truly	truly	ADV
admet-1513	1093	16	long	long	ADJ
admet-1513	1093	17	-	-	PUNCT
admet-1513	1093	18	term	term	NOUN
admet-1513	1093	19	model	model	NOUN
admet-1513	1093	20	to	to	PART
admet-1513	1093	21	study	study	VERB
admet-1513	1093	22	the	the	DET
admet-1513	1093	23	molecular	molecular	ADJ
admet-1513	1093	24	basis	basis	NOUN
admet-1513	1093	25	for	for	ADP
admet-1513	1093	26	inflammatory	inflammatory	ADJ
admet-1513	1093	27	bowel	bowel	NOUN
admet-1513	1093	28	disease	disease	NOUN
admet-1513	1093	29	.	.	PUNCT
admet-1513	1094	1	gut	gut	VERB
admet-1513	1094	2	66	66	NUM
admet-1513	1094	3	(	(	PUNCT
admet-1513	1094	4	2017	2017	NUM
admet-1513	1094	5	)	)	PUNCT
admet-1513	1094	6	21932195	21932195	NUM
admet-1513	1094	7	.	.	PUNCT
admet-1513	1095	1	https://doi.org/10.1136/gutjnl-2016-313667	https://doi.org/10.1136/gutjnl-2016-313667	NOUN
admet-1513	1096	1	[	[	X
admet-1513	1096	2	112	112	NUM
admet-1513	1096	3	]	]	PUNCT
admet-1513	1096	4	t.	t.	PROPN
admet-1513	1096	5	sato	sato	PROPN
admet-1513	1096	6	,	,	PUNCT
admet-1513	1096	7	r.g	r.g	PROPN
admet-1513	1096	8	.	.	PROPN
admet-1513	1096	9	vries	vries	PROPN
admet-1513	1096	10	,	,	PUNCT
admet-1513	1096	11	h.j	h.j	PROPN
admet-1513	1096	12	.	.	PROPN
admet-1513	1096	13	snippert	snippert	PROPN
admet-1513	1096	14	,	,	PUNCT
admet-1513	1096	15	m.	m.	PROPN
admet-1513	1096	16	van	van	PROPN
admet-1513	1096	17	de	de	PROPN
admet-1513	1096	18	wetering	wetering	PROPN
admet-1513	1096	19	,	,	PUNCT
admet-1513	1096	20	n.	n.	PROPN
admet-1513	1096	21	barker	barker	PROPN
admet-1513	1096	22	,	,	PUNCT
admet-1513	1096	23	d.e	d.e	PROPN
admet-1513	1096	24	.	.	PROPN
admet-1513	1096	25	stange	stange	PROPN
admet-1513	1096	26	,	,	PUNCT
admet-1513	1096	27	j.h	j.h	PROPN
admet-1513	1096	28	.	.	PROPN
admet-1513	1096	29	van	van	PROPN
admet-1513	1096	30	es	es	PROPN
admet-1513	1096	31	,	,	PUNCT
admet-1513	1096	32	a.	a.	NOUN
admet-1513	1096	33	abo	abo	NOUN
admet-1513	1096	34	,	,	PUNCT
admet-1513	1096	35	p.	p.	NOUN
admet-1513	1096	36	kujala	kujala	PROPN
admet-1513	1096	37	,	,	PUNCT
admet-1513	1096	38	p.j	p.j	PROPN
admet-1513	1096	39	.	.	PROPN
admet-1513	1096	40	peters	peters	PROPN
admet-1513	1096	41	,	,	PUNCT
admet-1513	1096	42	h.	h.	PROPN
admet-1513	1096	43	clevers	clevers	PROPN
admet-1513	1096	44	.	.	PUNCT
admet-1513	1097	1	single	single	ADJ
admet-1513	1097	2	lgr5	lgr5	NOUN
admet-1513	1097	3	stem	stem	NOUN
admet-1513	1097	4	cells	cell	NOUN
admet-1513	1097	5	build	build	VERB
admet-1513	1097	6	crypt	crypt	NOUN
admet-1513	1097	7	-	-	PUNCT
admet-1513	1097	8	villus	villus	NOUN
admet-1513	1097	9	structures	structure	NOUN
admet-1513	1097	10	in	in	ADP
admet-1513	1097	11	vitro	vitro	ADJ
admet-1513	1097	12	without	without	ADP
admet-1513	1097	13	a	a	DET
admet-1513	1097	14	mesenchymal	mesenchymal	ADJ
admet-1513	1097	15	niche	niche	NOUN
admet-1513	1097	16	.	.	PUNCT
admet-1513	1098	1	nature	nature	NOUN
admet-1513	1098	2	459	459	NUM
admet-1513	1098	3	(	(	PUNCT
admet-1513	1098	4	2009	2009	NUM
admet-1513	1098	5	)	)	PUNCT
admet-1513	1098	6	262	262	NUM
admet-1513	1098	7	-	-	SYM
admet-1513	1098	8	265	265	NUM
admet-1513	1098	9	.	.	PUNCT
admet-1513	1099	1	https://doi.org/10.1038/nature07935	https://doi.org/10.1038/nature07935	PROPN
admet-1513	1099	2	.	.	PUNCT
admet-1513	1100	1	[	[	X
admet-1513	1100	2	113	113	NUM
admet-1513	1100	3	]	]	PUNCT
admet-1513	1100	4	t.	t.	PROPN
admet-1513	1100	5	sato	sato	PROPN
admet-1513	1100	6	,	,	PUNCT
admet-1513	1100	7	h.	h.	PROPN
admet-1513	1100	8	clevers	clevers	PROPN
admet-1513	1100	9	.	.	PUNCT
admet-1513	1101	1	growing	grow	VERB
admet-1513	1101	2	self	self	NOUN
admet-1513	1101	3	-	-	PUNCT
admet-1513	1101	4	organizing	organize	VERB
admet-1513	1101	5	mini	mini	NOUN
admet-1513	1101	6	-	-	NOUN
admet-1513	1101	7	guts	gut	NOUN
admet-1513	1101	8	from	from	ADP
admet-1513	1101	9	a	a	DET
admet-1513	1101	10	single	single	ADJ
admet-1513	1101	11	intestinal	intestinal	ADJ
admet-1513	1101	12	stem	stem	NOUN
admet-1513	1101	13	cell	cell	NOUN
admet-1513	1101	14	:	:	PUNCT
admet-1513	1101	15	mechanism	mechanism	NOUN
admet-1513	1101	16	and	and	CCONJ
admet-1513	1101	17	applications	application	NOUN
admet-1513	1101	18	.	.	PUNCT
admet-1513	1102	1	science	science	NOUN
admet-1513	1102	2	340	340	NUM
admet-1513	1102	3	(	(	PUNCT
admet-1513	1102	4	2013	2013	NUM
admet-1513	1102	5	)	)	PUNCT
admet-1513	1102	6	1190	1190	NUM
admet-1513	1102	7	-	-	SYM
admet-1513	1102	8	1194	1194	NUM
admet-1513	1102	9	.	.	PUNCT
admet-1513	1103	1	https://doi.org/10.1126/science.1234852	https://doi.org/10.1126/science.1234852	ADJ
admet-1513	1103	2	.	.	PUNCT
admet-1513	1104	1	[	[	X
admet-1513	1104	2	114	114	NUM
admet-1513	1104	3	]	]	PUNCT
admet-1513	1104	4	t.	t.	PROPN
admet-1513	1104	5	zietek	zietek	PROPN
admet-1513	1104	6	,	,	PUNCT
admet-1513	1104	7	p.	p.	NOUN
admet-1513	1104	8	giesbertz	giesbertz	NOUN
admet-1513	1104	9	,	,	PUNCT
admet-1513	1104	10	m.	m.	NOUN
admet-1513	1104	11	ewers	ewer	NOUN
admet-1513	1104	12	,	,	PUNCT
admet-1513	1104	13	f.	f.	PROPN
admet-1513	1104	14	reichart	reichart	PROPN
admet-1513	1104	15	,	,	PUNCT
admet-1513	1104	16	m.	m.	NOUN
admet-1513	1104	17	weinmüller	weinmüller	PROPN
admet-1513	1104	18	,	,	PUNCT
admet-1513	1104	19	e.	e.	PROPN
admet-1513	1104	20	urbauer	urbauer	PROPN
admet-1513	1104	21	,	,	PUNCT
admet-1513	1104	22	d.	d.	PROPN
admet-1513	1104	23	haller	haller	PROPN
admet-1513	1104	24	,	,	PUNCT
admet-1513	1104	25	i.e.	i.e.	X
admet-1513	1104	26	demir	demir	PROPN
admet-1513	1104	27	,	,	PUNCT
admet-1513	1104	28	g.o	g.o	PROPN
admet-1513	1104	29	.	.	PROPN
admet-1513	1104	30	ceyhan	ceyhan	PROPN
admet-1513	1104	31	,	,	PUNCT
admet-1513	1104	32	h.	h.	PROPN
admet-1513	1104	33	kessler	kessler	PROPN
admet-1513	1104	34	,	,	PUNCT
admet-1513	1104	35	e.	e.	PROPN
admet-1513	1104	36	rath	rath	PROPN
admet-1513	1104	37	.	.	PUNCT
admet-1513	1105	1	organoids	organoid	NOUN
admet-1513	1105	2	to	to	PART
admet-1513	1105	3	study	study	VERB
admet-1513	1105	4	intestinal	intestinal	ADJ
admet-1513	1105	5	nutrient	nutrient	NOUN
admet-1513	1105	6	transport	transport	NOUN
admet-1513	1105	7	,	,	PUNCT
admet-1513	1105	8	drug	drug	NOUN
admet-1513	1105	9	uptake	uptake	NOUN
admet-1513	1105	10	and	and	CCONJ
admet-1513	1105	11	metabolism	metabolism	NOUN
admet-1513	1105	12	update	update	NOUN
admet-1513	1105	13	to	to	ADP
admet-1513	1105	14	the	the	DET
admet-1513	1105	15	human	human	ADJ
admet-1513	1105	16	model	model	NOUN
admet-1513	1105	17	and	and	CCONJ
admet-1513	1105	18	expansion	expansion	NOUN
admet-1513	1105	19	of	of	ADP
admet-1513	1105	20	applications	application	NOUN
admet-1513	1105	21	.	.	PUNCT
admet-1513	1106	1	front	front	NOUN
admet-1513	1106	2	.	.	PUNCT
admet-1513	1107	1	bioeng	bioeng	PROPN
admet-1513	1107	2	.	.	PUNCT
admet-1513	1107	3	biotechnol	biotechnol	PROPN
admet-1513	1107	4	.	.	PUNCT
admet-1513	1108	1	8	8	NUM
admet-1513	1108	2	(	(	PUNCT
admet-1513	1108	3	2020	2020	NUM
admet-1513	1108	4	)	)	PUNCT
admet-1513	1108	5	577656	577656	NUM
admet-1513	1108	6	.	.	PUNCT
admet-1513	1109	1	https://doi.org/10.3389/fbioe.2020.577656	https://doi.org/10.3389/fbioe.2020.577656	PROPN
admet-1513	1109	2	.	.	PROPN
admet-1513	1109	3	https://doi.org/10.1038/nature09691	https://doi.org/10.1038/nature09691	PROPN
admet-1513	1109	4	https://doi.org/10.1038/nature09691	https://doi.org/10.1038/nature09691	PROPN
admet-1513	1109	5	https://doi.org/10.1002/stem.1344	https://doi.org/10.1002/stem.1344	PROPN
admet-1513	1109	6	https://doi.org/10.1002/stem.1344	https://doi.org/10.1002/stem.1344	PROPN
admet-1513	1109	7	https://doi.org/10.1038/nature13863	https://doi.org/10.1038/nature13863	PROPN
admet-1513	1109	8	https://doi.org/10.1038/nature13863	https://doi.org/10.1038/nature13863	PROPN
admet-1513	1109	9	https://doi.org/10.1242/dev.096628	https://doi.org/10.1242/dev.096628	PROPN
admet-1513	1109	10	https://doi.org/10.1016/j.stem.2018.11.016	https://doi.org/10.1016/j.stem.2018.11.016	PROPN
admet-1513	1109	11	https://doi.org/10.1038/s41598-020-63151-z	https://doi.org/10.1038/s41598-020-63151-z	NOUN
admet-1513	1109	12	https://doi.org/10.1038/s41598-020-63151-z	https://doi.org/10.1038/s41598-020-63151-z	NOUN
admet-1513	1109	13	https://doi.org/10.1007/s11626-020-00526-6	https://doi.org/10.1007/s11626-020-00526-6	NUM
admet-1513	1109	14	https://doi.org/10.1007/s11626-020-00526-6	https://doi.org/10.1007/s11626-020-00526-6	NUM
admet-1513	1109	15	https://doi.org/10.1038/nbt1163	https://doi.org/10.1038/nbt1163	PROPN
admet-1513	1109	16	https://doi.org/10.1038/nature09637	https://doi.org/10.1038/nature09637	PROPN
admet-1513	1109	17	https://doi.org/10.1016/j.ijpharm.2013.10.003	https://doi.org/10.1016/j.ijpharm.2013.10.003	PROPN
admet-1513	1109	18	https://doi.org/10.1016/j.ijpharm.2013.10.003	https://doi.org/10.1016/j.ijpharm.2013.10.003	PROPN
admet-1513	1109	19	https://doi.org/10.1136/gutjnl-2016-313667	https://doi.org/10.1136/gutjnl-2016-313667	PROPN
admet-1513	1109	20	https://doi.org/10.1038/nature07935	https://doi.org/10.1038/nature07935	PROPN
admet-1513	1109	21	https://doi.org/10.1126/science.1234852	https://doi.org/10.1126/science.1234852	ADJ
admet-1513	1109	22	https://doi.org/10.3389/fbioe.2020.577656	https://doi.org/10.3389/fbioe.2020.577656	PROPN
admet-1513	1109	23	admet	admet	PROPN
admet-1513	1109	24	&	&	CCONJ
admet-1513	1109	25	dmpk	dmpk	PROPN
admet-1513	1109	26	11(1	11(1	NUM
admet-1513	1109	27	)	)	PUNCT
admet-1513	1109	28	(	(	PUNCT
admet-1513	1109	29	2023	2023	NUM
admet-1513	1109	30	)	)	PUNCT
admet-1513	1109	31	1	1	NUM
admet-1513	1109	32	-	-	SYM
admet-1513	1109	33	32	32	NUM
admet-1513	1109	34	2d	2d	NOUN
admet-1513	1109	35	and	and	CCONJ
admet-1513	1109	36	3d	3d	NOUN
admet-1513	1109	37	adme	adme	PROPN
admet-1513	1109	38	-	-	PUNCT
admet-1513	1109	39	tox	tox	NOUN
admet-1513	1109	40	cell	cell	NOUN
admet-1513	1109	41	culture	culture	NOUN
admet-1513	1109	42	screening	screen	VERB
admet-1513	1109	43	:	:	PUNCT
admet-1513	1109	44	a	a	DET
admet-1513	1109	45	review	review	NOUN
admet-1513	1109	46	doi	doi	NOUN
admet-1513	1109	47	:	:	PUNCT
admet-1513	1109	48	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	1109	49	25	25	NUM
admet-1513	1110	1	[	[	NOUN
admet-1513	1110	2	115	115	NUM
admet-1513	1110	3	]	]	PUNCT
admet-1513	1110	4	s.	s.	PROPN
admet-1513	1110	5	rahmani	rahmani	PROPN
admet-1513	1110	6	,	,	PUNCT
admet-1513	1110	7	n.m	n.m	PROPN
admet-1513	1110	8	.	.	PROPN
admet-1513	1110	9	breyner	breyner	NOUN
admet-1513	1110	10	,	,	PUNCT
admet-1513	1110	11	h.m	h.m	PROPN
admet-1513	1110	12	.	.	PROPN
admet-1513	1110	13	su	su	PROPN
admet-1513	1110	14	,	,	PUNCT
admet-1513	1110	15	e.f	e.f	PROPN
admet-1513	1110	16	.	.	PROPN
admet-1513	1110	17	verdu	verdu	PROPN
admet-1513	1110	18	,	,	PUNCT
admet-1513	1110	19	t.f	t.f	PROPN
admet-1513	1110	20	.	.	PROPN
admet-1513	1110	21	didar	didar	PROPN
admet-1513	1110	22	.	.	PUNCT
admet-1513	1111	1	intestinal	intestinal	ADJ
admet-1513	1111	2	organoids	organoid	NOUN
admet-1513	1111	3	:	:	PUNCT
admet-1513	1111	4	a	a	DET
admet-1513	1111	5	new	new	ADJ
admet-1513	1111	6	paradigm	paradigm	NOUN
admet-1513	1111	7	for	for	ADP
admet-1513	1111	8	engineering	engineer	VERB
admet-1513	1111	9	intestinal	intestinal	ADJ
admet-1513	1111	10	epithelium	epithelium	NOUN
admet-1513	1111	11	in	in	ADP
admet-1513	1111	12	vitro	vitro	X
admet-1513	1111	13	.	.	PUNCT
admet-1513	1112	1	biomaterials	biomaterial	NOUN
admet-1513	1112	2	194	194	NUM
admet-1513	1112	3	(	(	PUNCT
admet-1513	1112	4	2019	2019	NUM
admet-1513	1112	5	)	)	PUNCT
admet-1513	1112	6	195	195	NUM
admet-1513	1112	7	-	-	SYM
admet-1513	1112	8	214	214	NUM
admet-1513	1112	9	.	.	PUNCT
admet-1513	1113	1	https://doi.org/10.1016/j.biomaterials.2018.12.006	https://doi.org/10.1016/j.biomaterials.2018.12.006	NOUN
admet-1513	1113	2	.	.	PUNCT
admet-1513	1114	1	[	[	X
admet-1513	1114	2	116	116	X
admet-1513	1114	3	]	]	X
admet-1513	1114	4	a.	a.	NOUN
admet-1513	1114	5	bein	bein	PROPN
admet-1513	1114	6	,	,	PUNCT
admet-1513	1114	7	w.	w.	PROPN
admet-1513	1114	8	shin	shin	PROPN
admet-1513	1114	9	,	,	PUNCT
admet-1513	1114	10	s.	s.	PROPN
admet-1513	1114	11	jalili	jalili	PROPN
admet-1513	1114	12	-	-	PUNCT
admet-1513	1114	13	firoozinezhad	firoozinezhad	VERB
admet-1513	1114	14	,	,	PUNCT
admet-1513	1114	15	m.h	m.h	PROPN
admet-1513	1114	16	.	.	PROPN
admet-1513	1114	17	park	park	PROPN
admet-1513	1114	18	,	,	PUNCT
admet-1513	1114	19	a.	a.	PROPN
admet-1513	1114	20	sontheimer	sontheimer	PROPN
admet-1513	1114	21	-	-	PUNCT
admet-1513	1114	22	phelps	phelps	PROPN
admet-1513	1114	23	,	,	PUNCT
admet-1513	1114	24	a.	a.	PROPN
admet-1513	1114	25	tovaglieri	tovaglieri	PROPN
admet-1513	1114	26	,	,	PUNCT
admet-1513	1114	27	a.	a.	NOUN
admet-1513	1114	28	chalkiadaki	chalkiadaki	PROPN
admet-1513	1114	29	,	,	PUNCT
admet-1513	1114	30	h.j	h.j	PROPN
admet-1513	1114	31	.	.	PROPN
admet-1513	1114	32	kim	kim	PROPN
admet-1513	1114	33	,	,	PUNCT
admet-1513	1114	34	d.e	d.e	PROPN
admet-1513	1114	35	.	.	PROPN
admet-1513	1114	36	ingber	ingber	PROPN
admet-1513	1114	37	.	.	PUNCT
admet-1513	1115	1	microfluidic	microfluidic	ADJ
admet-1513	1115	2	organ	organ	NOUN
admet-1513	1115	3	-	-	PUNCT
admet-1513	1115	4	on	on	ADP
admet-1513	1115	5	-	-	PUNCT
admet-1513	1115	6	a	a	DET
admet-1513	1115	7	-	-	PUNCT
admet-1513	1115	8	chip	chip	NOUN
admet-1513	1115	9	models	model	NOUN
admet-1513	1115	10	of	of	ADP
admet-1513	1115	11	human	human	ADJ
admet-1513	1115	12	intestine	intestine	NOUN
admet-1513	1115	13	.	.	PUNCT
admet-1513	1116	1	cell	cell	NOUN
admet-1513	1116	2	mol	mol	PROPN
admet-1513	1116	3	.	.	PUNCT
admet-1513	1116	4	gastroenterol	gastroenterol	NOUN
admet-1513	1116	5	.	.	PUNCT
admet-1513	1117	1	hepatol	hepatol	ADJ
admet-1513	1117	2	.	.	PUNCT
admet-1513	1118	1	5	5	NUM
admet-1513	1118	2	(	(	PUNCT
admet-1513	1118	3	2018	2018	NUM
admet-1513	1118	4	)	)	PUNCT
admet-1513	1118	5	659	659	NUM
admet-1513	1118	6	-	-	SYM
admet-1513	1118	7	668	668	NUM
admet-1513	1118	8	.	.	PUNCT
admet-1513	1119	1	https://doi.org/10.1016/j.jcmgh.2017.12.010	https://doi.org/10.1016/j.jcmgh.2017.12.010	NUM
admet-1513	1119	2	.	.	PUNCT
admet-1513	1120	1	[	[	X
admet-1513	1120	2	117	117	NUM
admet-1513	1120	3	]	]	PUNCT
admet-1513	1120	4	a.	a.	NOUN
admet-1513	1120	5	sontheimer	sontheimer	PROPN
admet-1513	1120	6	-	-	PUNCT
admet-1513	1120	7	phelps	phelps	PROPN
admet-1513	1120	8	,	,	PUNCT
admet-1513	1120	9	b.a	b.a	PROPN
admet-1513	1120	10	.	.	PROPN
admet-1513	1120	11	hassell	hassell	PROPN
admet-1513	1120	12	,	,	PUNCT
admet-1513	1120	13	d.e	d.e	PROPN
admet-1513	1120	14	.	.	PROPN
admet-1513	1120	15	ingber	ingber	PROPN
admet-1513	1120	16	.	.	PUNCT
admet-1513	1121	1	modelling	model	VERB
admet-1513	1121	2	cancer	cancer	NOUN
admet-1513	1121	3	in	in	ADP
admet-1513	1121	4	microfluidic	microfluidic	ADJ
admet-1513	1121	5	human	human	ADJ
admet-1513	1121	6	organs	organ	NOUN
admet-1513	1121	7	-	-	NOUN
admet-1513	1121	8	onchips	onchip	NOUN
admet-1513	1121	9	.	.	PUNCT
admet-1513	1122	1	nat	nat	PROPN
admet-1513	1122	2	.	.	PUNCT
admet-1513	1123	1	rev	rev	PROPN
admet-1513	1123	2	.	.	PROPN
admet-1513	1124	1	cancer	cancer	NOUN
admet-1513	1124	2	19	19	NUM
admet-1513	1124	3	(	(	PUNCT
admet-1513	1124	4	2019	2019	NUM
admet-1513	1124	5	)	)	PUNCT
admet-1513	1124	6	65	65	NUM
admet-1513	1124	7	-	-	SYM
admet-1513	1124	8	81	81	NUM
admet-1513	1124	9	.	.	PUNCT
admet-1513	1124	10	https://doi.org/10.1038/s41568-018-0104-6	https://doi.org/10.1038/s41568-018-0104-6	NUM
admet-1513	1124	11	.	.	PUNCT
admet-1513	1125	1	[	[	X
admet-1513	1125	2	118	118	NUM
admet-1513	1125	3	]	]	X
admet-1513	1125	4	s.n	s.n	PROPN
admet-1513	1125	5	.	.	PROPN
admet-1513	1125	6	bhatia	bhatia	PROPN
admet-1513	1125	7	,	,	PUNCT
admet-1513	1125	8	d.e	d.e	PROPN
admet-1513	1125	9	.	.	PROPN
admet-1513	1125	10	ingber	ingber	PROPN
admet-1513	1125	11	.	.	PUNCT
admet-1513	1126	1	microfluidic	microfluidic	ADJ
admet-1513	1126	2	organs	organ	NOUN
admet-1513	1126	3	-	-	PUNCT
admet-1513	1126	4	on	on	ADP
admet-1513	1126	5	-	-	PUNCT
admet-1513	1126	6	chips	chip	NOUN
admet-1513	1126	7	.	.	PUNCT
admet-1513	1127	1	nat	nat	NOUN
admet-1513	1127	2	.	.	PUNCT
admet-1513	1128	1	biotechnol	biotechnol	PROPN
admet-1513	1128	2	.	.	PUNCT
admet-1513	1129	1	32	32	NUM
admet-1513	1129	2	(	(	PUNCT
admet-1513	1129	3	2014	2014	NUM
admet-1513	1129	4	)	)	PUNCT
admet-1513	1130	1	760	760	NUM
admet-1513	1130	2	-	-	SYM
admet-1513	1130	3	772	772	NUM
admet-1513	1130	4	.	.	PUNCT
admet-1513	1131	1	https://doi.org/10.1038/nbt.2989	https://doi.org/10.1038/nbt.2989	PROPN
admet-1513	1131	2	.	.	PUNCT
admet-1513	1132	1	[	[	X
admet-1513	1132	2	119	119	NUM
admet-1513	1132	3	]	]	X
admet-1513	1132	4	h.	h.	PROPN
admet-1513	1132	5	uchida	uchida	PROPN
admet-1513	1132	6	,	,	PUNCT
admet-1513	1132	7	m.	m.	PROPN
admet-1513	1132	8	machida	machida	PROPN
admet-1513	1132	9	,	,	PUNCT
admet-1513	1132	10	t.	t.	PROPN
admet-1513	1132	11	miura	miura	PROPN
admet-1513	1132	12	,	,	PUNCT
admet-1513	1132	13	t.	t.	PROPN
admet-1513	1132	14	kawasaki	kawasaki	PROPN
admet-1513	1132	15	,	,	PUNCT
admet-1513	1132	16	t.	t.	PROPN
admet-1513	1132	17	okazaki	okazaki	PROPN
admet-1513	1132	18	,	,	PUNCT
admet-1513	1132	19	k.	k.	PROPN
admet-1513	1132	20	sasaki	sasaki	PROPN
admet-1513	1132	21	,	,	PUNCT
admet-1513	1132	22	s.	s.	PROPN
admet-1513	1132	23	sakamoto	sakamoto	PROPN
admet-1513	1132	24	,	,	PUNCT
admet-1513	1132	25	n.	n.	PROPN
admet-1513	1132	26	ohuchi	ohuchi	PROPN
admet-1513	1132	27	,	,	PUNCT
admet-1513	1132	28	m.	m.	NOUN
admet-1513	1132	29	kasahara	kasahara	PROPN
admet-1513	1132	30	,	,	PUNCT
admet-1513	1132	31	a.	a.	PROPN
admet-1513	1132	32	umezawa	umezawa	PROPN
admet-1513	1132	33	,	,	PUNCT
admet-1513	1132	34	h.	h.	PROPN
admet-1513	1132	35	akutsu	akutsu	PROPN
admet-1513	1132	36	.	.	PUNCT
admet-1513	1133	1	a	a	DET
admet-1513	1133	2	xenogeneic	xenogeneic	VERB
admet-1513	1133	3	-	-	PUNCT
admet-1513	1133	4	free	free	ADJ
admet-1513	1133	5	system	system	NOUN
admet-1513	1133	6	generating	generate	VERB
admet-1513	1133	7	functional	functional	ADJ
admet-1513	1133	8	human	human	ADJ
admet-1513	1133	9	gut	gut	NOUN
admet-1513	1133	10	organoids	organoid	NOUN
admet-1513	1133	11	from	from	ADP
admet-1513	1133	12	pluripotent	pluripotent	ADJ
admet-1513	1133	13	stem	stem	NOUN
admet-1513	1133	14	cells	cell	NOUN
admet-1513	1133	15	.	.	PUNCT
admet-1513	1134	1	jci	jci	PROPN
admet-1513	1134	2	insight	insight	PROPN
admet-1513	1134	3	2	2	NUM
admet-1513	1134	4	(	(	PUNCT
admet-1513	1134	5	2017	2017	NUM
admet-1513	1134	6	)	)	PUNCT
admet-1513	1134	7	e86492	e86492	PROPN
admet-1513	1134	8	.	.	PUNCT
admet-1513	1134	9	https://doi.org/10.1172/jci.insight.86492	https://doi.org/10.1172/jci.insight.86492	PROPN
admet-1513	1134	10	.	.	PUNCT
admet-1513	1135	1	[	[	X
admet-1513	1135	2	120	120	NUM
admet-1513	1135	3	]	]	PUNCT
admet-1513	1135	4	t.	t.	PROPN
admet-1513	1135	5	zietek	zietek	PROPN
admet-1513	1135	6	,	,	PUNCT
admet-1513	1135	7	e.	e.	PROPN
admet-1513	1135	8	rath	rath	PROPN
admet-1513	1135	9	,	,	PUNCT
admet-1513	1135	10	d.	d.	PROPN
admet-1513	1135	11	haller	haller	PROPN
admet-1513	1135	12	,	,	PUNCT
admet-1513	1135	13	h.	h.	PROPN
admet-1513	1135	14	daniel	daniel	PROPN
admet-1513	1135	15	.	.	PUNCT
admet-1513	1136	1	intestinal	intestinal	ADJ
admet-1513	1136	2	organoids	organoid	NOUN
admet-1513	1136	3	for	for	ADP
admet-1513	1136	4	assessing	assess	VERB
admet-1513	1136	5	nutrient	nutrient	ADJ
admet-1513	1136	6	transport	transport	NOUN
admet-1513	1136	7	,	,	PUNCT
admet-1513	1136	8	sensing	sense	VERB
admet-1513	1136	9	and	and	CCONJ
admet-1513	1136	10	incretin	incretin	ADJ
admet-1513	1136	11	secretion	secretion	NOUN
admet-1513	1136	12	.	.	PUNCT
admet-1513	1137	1	sci	sci	PROPN
admet-1513	1137	2	.	.	PROPN
admet-1513	1137	3	rep	rep	PROPN
admet-1513	1137	4	.	.	PROPN
admet-1513	1137	5	5	5	NUM
admet-1513	1137	6	(	(	PUNCT
admet-1513	1137	7	2015	2015	NUM
admet-1513	1137	8	)	)	PUNCT
admet-1513	1137	9	16831	16831	NUM
admet-1513	1137	10	.	.	PUNCT
admet-1513	1138	1	https://doi.org/10.1038/srep16831	https://doi.org/10.1038/srep16831	PROPN
admet-1513	1138	2	.	.	PUNCT
admet-1513	1139	1	[	[	X
admet-1513	1139	2	121	121	NUM
admet-1513	1139	3	]	]	X
admet-1513	1139	4	i.a	i.a	PROPN
admet-1513	1139	5	.	.	PROPN
admet-1513	1139	6	williamson	williamson	PROPN
admet-1513	1139	7	,	,	PUNCT
admet-1513	1139	8	j.w	j.w	PROPN
admet-1513	1139	9	.	.	PROPN
admet-1513	1139	10	arnold	arnold	PROPN
admet-1513	1139	11	,	,	PUNCT
admet-1513	1139	12	l.a	l.a	PROPN
admet-1513	1139	13	.	.	PROPN
admet-1513	1139	14	samsa	samsa	PROPN
admet-1513	1139	15	,	,	PUNCT
admet-1513	1139	16	l.	l.	PROPN
admet-1513	1139	17	gaynor	gaynor	PROPN
admet-1513	1139	18	,	,	PUNCT
admet-1513	1139	19	m.	m.	NOUN
admet-1513	1139	20	disalvo	disalvo	PROPN
admet-1513	1139	21	,	,	PUNCT
admet-1513	1139	22	j.l	j.l	PROPN
admet-1513	1139	23	.	.	PROPN
admet-1513	1139	24	cocchiaro	cocchiaro	PROPN
admet-1513	1139	25	,	,	PUNCT
admet-1513	1139	26	i.	i.	PROPN
admet-1513	1139	27	carroll	carroll	PROPN
admet-1513	1139	28	,	,	PUNCT
admet-1513	1139	29	m.a	m.a	PROPN
admet-1513	1139	30	.	.	PROPN
admet-1513	1139	31	azcarate	azcarate	NOUN
admet-1513	1139	32	-	-	PUNCT
admet-1513	1139	33	peril	peril	NOUN
admet-1513	1139	34	,	,	PUNCT
admet-1513	1139	35	j.f	j.f	PROPN
admet-1513	1139	36	.	.	PROPN
admet-1513	1139	37	rawls	rawls	PROPN
admet-1513	1139	38	,	,	PUNCT
admet-1513	1139	39	n.l	n.l	PROPN
admet-1513	1139	40	.	.	PROPN
admet-1513	1139	41	allbritton	allbritton	PROPN
admet-1513	1139	42	,	,	PUNCT
admet-1513	1139	43	s.t	s.t	PROPN
admet-1513	1139	44	.	.	PROPN
admet-1513	1139	45	magness	magness	PROPN
admet-1513	1139	46	.	.	PUNCT
admet-1513	1140	1	a	a	DET
admet-1513	1140	2	high	high	ADJ
admet-1513	1140	3	-	-	PUNCT
admet-1513	1140	4	throughput	throughput	NOUN
admet-1513	1140	5	organoid	organoid	NOUN
admet-1513	1140	6	microinjection	microinjection	NOUN
admet-1513	1140	7	platform	platform	NOUN
admet-1513	1140	8	to	to	PART
admet-1513	1140	9	study	study	VERB
admet-1513	1140	10	gastrointestinal	gastrointestinal	ADJ
admet-1513	1140	11	microbiota	microbiota	NOUN
admet-1513	1140	12	and	and	CCONJ
admet-1513	1140	13	luminal	luminal	ADJ
admet-1513	1140	14	physiology	physiology	NOUN
admet-1513	1140	15	.	.	PUNCT
admet-1513	1141	1	cell	cell	PROPN
admet-1513	1141	2	mol	mol	PROPN
admet-1513	1141	3	.	.	PUNCT
admet-1513	1141	4	gastroenterol	gastroenterol	NOUN
admet-1513	1141	5	.	.	PUNCT
admet-1513	1142	1	hepatol	hepatol	ADJ
admet-1513	1142	2	.	.	PUNCT
admet-1513	1143	1	6	6	NUM
admet-1513	1143	2	(	(	PUNCT
admet-1513	1143	3	2018	2018	NUM
admet-1513	1143	4	)	)	PUNCT
admet-1513	1143	5	301	301	NUM
admet-1513	1143	6	-	-	NUM
admet-1513	1143	7	319	319	NUM
admet-1513	1143	8	.	.	PUNCT
admet-1513	1144	1	https://doi.org/10.1016/j.jcmgh.2018.05.004	https://doi.org/10.1016/j.jcmgh.2018.05.004	PROPN
admet-1513	1144	2	.	.	PUNCT
admet-1513	1145	1	[	[	X
admet-1513	1145	2	122	122	NUM
admet-1513	1145	3	]	]	X
admet-1513	1145	4	t.	t.	PROPN
admet-1513	1145	5	roodsant	roodsant	PROPN
admet-1513	1145	6	,	,	PUNCT
admet-1513	1145	7	m.	m.	NOUN
admet-1513	1145	8	navis	navis	PROPN
admet-1513	1145	9	,	,	PUNCT
admet-1513	1145	10	i.	i.	PROPN
admet-1513	1145	11	aknouch	aknouch	PROPN
admet-1513	1145	12	,	,	PUNCT
admet-1513	1145	13	i.b	i.b	PROPN
admet-1513	1145	14	.	.	PROPN
admet-1513	1145	15	renes	renes	PROPN
admet-1513	1145	16	,	,	PUNCT
admet-1513	1145	17	r.m	r.m	PROPN
admet-1513	1145	18	.	.	PROPN
admet-1513	1145	19	van	van	PROPN
admet-1513	1145	20	elburg	elburg	PROPN
admet-1513	1145	21	,	,	PUNCT
admet-1513	1145	22	d.	d.	PROPN
admet-1513	1145	23	pajkrt	pajkrt	PROPN
admet-1513	1145	24	,	,	PUNCT
admet-1513	1145	25	k.c	k.c	PROPN
admet-1513	1145	26	.	.	PROPN
admet-1513	1145	27	wolthers	wolther	NOUN
admet-1513	1145	28	,	,	PUNCT
admet-1513	1145	29	c.	c.	PROPN
admet-1513	1145	30	schultsz	schultsz	PROPN
admet-1513	1145	31	,	,	PUNCT
admet-1513	1145	32	k.c.h	k.c.h	PROPN
admet-1513	1145	33	.	.	PUNCT
admet-1513	1145	34	van	van	PROPN
admet-1513	1145	35	der	der	PROPN
admet-1513	1145	36	ark	ark	PROPN
admet-1513	1145	37	,	,	PUNCT
admet-1513	1145	38	a.	a.	NOUN
admet-1513	1145	39	sridhar	sridhar	PROPN
admet-1513	1145	40	,	,	PUNCT
admet-1513	1145	41	v.	v.	PROPN
admet-1513	1145	42	muncan	muncan	PROPN
admet-1513	1145	43	.	.	PUNCT
admet-1513	1146	1	a	a	DET
admet-1513	1146	2	human	human	ADJ
admet-1513	1146	3	2d	2d	PROPN
admet-1513	1146	4	primary	primary	ADJ
admet-1513	1146	5	organoid	organoid	NOUN
admet-1513	1146	6	-	-	PUNCT
admet-1513	1146	7	derived	derive	VERB
admet-1513	1146	8	epithelial	epithelial	ADJ
admet-1513	1146	9	monolayer	monolayer	NOUN
admet-1513	1146	10	model	model	NOUN
admet-1513	1146	11	to	to	PART
admet-1513	1146	12	study	study	VERB
admet-1513	1146	13	host	host	NOUN
admet-1513	1146	14	-	-	PUNCT
admet-1513	1146	15	pathogen	pathogen	NOUN
admet-1513	1146	16	interaction	interaction	NOUN
admet-1513	1146	17	in	in	ADP
admet-1513	1146	18	the	the	DET
admet-1513	1146	19	small	small	ADJ
admet-1513	1146	20	intestine	intestine	NOUN
admet-1513	1146	21	.	.	PUNCT
admet-1513	1147	1	front	front	ADJ
admet-1513	1147	2	.	.	PUNCT
admet-1513	1148	1	cell	cell	NOUN
admet-1513	1148	2	infect	infect	NOUN
admet-1513	1148	3	.	.	PUNCT
admet-1513	1149	1	microbiol	microbiol	PROPN
admet-1513	1149	2	.	.	PUNCT
admet-1513	1150	1	10	10	NUM
admet-1513	1150	2	(	(	PUNCT
admet-1513	1150	3	2020	2020	NUM
admet-1513	1150	4	)	)	PUNCT
admet-1513	1150	5	272	272	NUM
admet-1513	1150	6	.	.	PUNCT
admet-1513	1151	1	https://doi.org/10.3389/fcimb.2020.00272	https://doi.org/10.3389/fcimb.2020.00272	PROPN
admet-1513	1151	2	.	.	PUNCT
admet-1513	1152	1	[	[	X
admet-1513	1152	2	123	123	NUM
admet-1513	1152	3	]	]	PUNCT
admet-1513	1152	4	m.	m.	NOUN
admet-1513	1152	5	kasendra	kasendra	PROPN
admet-1513	1152	6	,	,	PUNCT
admet-1513	1152	7	j.m	j.m	PROPN
admet-1513	1152	8	.	.	PROPN
admet-1513	1152	9	wells	wells	PROPN
admet-1513	1152	10	.	.	PUNCT
admet-1513	1153	1	a	a	DET
admet-1513	1153	2	window	window	NOUN
admet-1513	1153	3	into	into	ADP
admet-1513	1153	4	your	your	PRON
admet-1513	1153	5	gut	gut	NOUN
admet-1513	1153	6	:	:	PUNCT
admet-1513	1153	7	biologically	biologically	ADV
admet-1513	1153	8	inspired	inspire	VERB
admet-1513	1153	9	engineering	engineering	NOUN
admet-1513	1153	10	of	of	ADP
admet-1513	1153	11	mini	mini	ADJ
admet-1513	1153	12	-	-	ADJ
admet-1513	1153	13	gut	gut	ADJ
admet-1513	1153	14	tubes	tube	NOUN
admet-1513	1153	15	in	in	ADP
admet-1513	1153	16	vitro	vitro	X
admet-1513	1153	17	.	.	PUNCT
admet-1513	1154	1	dev	dev	PROPN
admet-1513	1154	2	.	.	PUNCT
admet-1513	1154	3	cell	cell	NOUN
admet-1513	1154	4	55	55	NUM
admet-1513	1154	5	(	(	PUNCT
admet-1513	1154	6	2020	2020	NUM
admet-1513	1154	7	)	)	PUNCT
admet-1513	1154	8	522	522	NUM
admet-1513	1154	9	-	-	SYM
admet-1513	1154	10	524	524	NUM
admet-1513	1154	11	.	.	PUNCT
admet-1513	1155	1	https://doi.org/10.1016/j.devcel.2020.11.015	https://doi.org/10.1016/j.devcel.2020.11.015	X
admet-1513	1155	2	.	.	PUNCT
admet-1513	1156	1	[	[	X
admet-1513	1156	2	124	124	NUM
admet-1513	1156	3	]	]	X
admet-1513	1156	4	n.	n.	PROPN
admet-1513	1156	5	gjorevski	gjorevski	PROPN
admet-1513	1156	6	,	,	PUNCT
admet-1513	1156	7	m.	m.	NOUN
admet-1513	1156	8	nikolaev	nikolaev	NOUN
admet-1513	1156	9	,	,	PUNCT
admet-1513	1156	10	t.e	t.e	PROPN
admet-1513	1156	11	.	.	PROPN
admet-1513	1156	12	brown	brown	PROPN
admet-1513	1156	13	,	,	PUNCT
admet-1513	1156	14	o.	o.	PROPN
admet-1513	1156	15	mitrofanova	mitrofanova	PROPN
admet-1513	1156	16	,	,	PUNCT
admet-1513	1156	17	n.	n.	PROPN
admet-1513	1156	18	brandenberg	brandenberg	PROPN
admet-1513	1156	19	,	,	PUNCT
admet-1513	1156	20	f.w	f.w	PROPN
admet-1513	1156	21	.	.	PROPN
admet-1513	1156	22	delrio	delrio	PROPN
admet-1513	1156	23	,	,	PUNCT
admet-1513	1156	24	f.m	f.m	PROPN
admet-1513	1156	25	.	.	PROPN
admet-1513	1156	26	yavitt	yavitt	PROPN
admet-1513	1156	27	,	,	PUNCT
admet-1513	1156	28	p.	p.	PROPN
admet-1513	1156	29	liberali	liberali	PROPN
admet-1513	1156	30	,	,	PUNCT
admet-1513	1156	31	k.s	k.s	PROPN
admet-1513	1156	32	.	.	PROPN
admet-1513	1156	33	anseth	anseth	PROPN
admet-1513	1156	34	,	,	PUNCT
admet-1513	1156	35	m.p	m.p	PROPN
admet-1513	1156	36	.	.	PROPN
admet-1513	1156	37	lutolf	lutolf	PROPN
admet-1513	1156	38	.	.	PUNCT
admet-1513	1157	1	tissue	tissue	NOUN
admet-1513	1157	2	geometry	geometry	NOUN
admet-1513	1157	3	drives	drive	VERB
admet-1513	1157	4	deterministic	deterministic	ADJ
admet-1513	1157	5	organoid	organoid	NOUN
admet-1513	1157	6	patterning	pattern	VERB
admet-1513	1157	7	.	.	PUNCT
admet-1513	1158	1	science	science	NOUN
admet-1513	1158	2	375	375	NUM
admet-1513	1158	3	(	(	PUNCT
admet-1513	1158	4	2022	2022	NUM
admet-1513	1158	5	)	)	PUNCT
admet-1513	1158	6	eaaw9021	eaaw9021	PROPN
admet-1513	1158	7	.	.	PUNCT
admet-1513	1158	8	https://doi.org/10.1126/science.aaw9021	https://doi.org/10.1126/science.aaw9021	PROPN
admet-1513	1158	9	.	.	PUNCT
admet-1513	1159	1	[	[	X
admet-1513	1159	2	125	125	NUM
admet-1513	1159	3	]	]	PUNCT
admet-1513	1159	4	m.	m.	NOUN
admet-1513	1159	5	nikolaev	nikolaev	NOUN
admet-1513	1159	6	,	,	PUNCT
admet-1513	1159	7	o.	o.	PROPN
admet-1513	1159	8	mitrofanova	mitrofanova	PROPN
admet-1513	1159	9	,	,	PUNCT
admet-1513	1159	10	n.	n.	PROPN
admet-1513	1159	11	broguiere	broguiere	PROPN
admet-1513	1159	12	,	,	PUNCT
admet-1513	1159	13	s.	s.	PROPN
admet-1513	1159	14	geraldo	geraldo	PROPN
admet-1513	1159	15	,	,	PUNCT
admet-1513	1159	16	d.	d.	PROPN
admet-1513	1159	17	dutta	dutta	PROPN
admet-1513	1159	18	,	,	PUNCT
admet-1513	1159	19	y.	y.	PROPN
admet-1513	1159	20	tabata	tabata	PROPN
admet-1513	1159	21	,	,	PUNCT
admet-1513	1159	22	b.	b.	PROPN
admet-1513	1159	23	elci	elci	NOUN
admet-1513	1159	24	,	,	PUNCT
admet-1513	1159	25	n.	n.	PROPN
admet-1513	1159	26	brandenberg	brandenberg	PROPN
admet-1513	1159	27	,	,	PUNCT
admet-1513	1159	28	i.	i.	PROPN
admet-1513	1159	29	kolotuev	kolotuev	PROPN
admet-1513	1159	30	,	,	PUNCT
admet-1513	1159	31	n.	n.	PROPN
admet-1513	1159	32	gjorevski	gjorevski	PROPN
admet-1513	1159	33	,	,	PUNCT
admet-1513	1159	34	h.	h.	PROPN
admet-1513	1159	35	clevers	clevers	PROPN
admet-1513	1159	36	,	,	PUNCT
admet-1513	1159	37	m.p	m.p	PROPN
admet-1513	1159	38	.	.	PROPN
admet-1513	1159	39	lutolf	lutolf	PROPN
admet-1513	1159	40	.	.	PUNCT
admet-1513	1160	1	homeostatic	homeostatic	ADJ
admet-1513	1160	2	mini	mini	NOUN
admet-1513	1160	3	-	-	NOUN
admet-1513	1160	4	intestines	intestine	NOUN
admet-1513	1160	5	through	through	ADP
admet-1513	1160	6	scaffold	scaffold	NOUN
admet-1513	1160	7	-	-	PUNCT
admet-1513	1160	8	guided	guide	VERB
admet-1513	1160	9	organoid	organoid	NOUN
admet-1513	1160	10	morphogenesis	morphogenesis	NOUN
admet-1513	1160	11	.	.	PUNCT
admet-1513	1161	1	nature	nature	NOUN
admet-1513	1161	2	585	585	NUM
admet-1513	1161	3	(	(	PUNCT
admet-1513	1161	4	2020	2020	NUM
admet-1513	1161	5	)	)	PUNCT
admet-1513	1161	6	574	574	NUM
admet-1513	1161	7	-	-	SYM
admet-1513	1161	8	578	578	NUM
admet-1513	1161	9	.	.	PUNCT
admet-1513	1162	1	https://doi.org/10.1038/s41586-020-2724-8	https://doi.org/10.1038/s41586-020-2724-8	NUM
admet-1513	1162	2	.	.	PUNCT
admet-1513	1163	1	[	[	X
admet-1513	1163	2	126	126	NUM
admet-1513	1163	3	]	]	X
admet-1513	1163	4	c.	c.	NOUN
admet-1513	1163	5	pérez	pérez	PROPN
admet-1513	1163	6	-	-	PUNCT
admet-1513	1163	7	gonzález	gonzález	PROPN
admet-1513	1163	8	,	,	PUNCT
admet-1513	1163	9	g.	g.	PROPN
admet-1513	1163	10	ceada	ceada	PROPN
admet-1513	1163	11	,	,	PUNCT
admet-1513	1163	12	f.	f.	PROPN
admet-1513	1163	13	greco	greco	PROPN
admet-1513	1163	14	,	,	PUNCT
admet-1513	1163	15	m.	m.	NOUN
admet-1513	1163	16	matejčić	matejčić	PROPN
admet-1513	1163	17	,	,	PUNCT
admet-1513	1163	18	m.	m.	NOUN
admet-1513	1163	19	gómez	gómez	PROPN
admet-1513	1163	20	-	-	PUNCT
admet-1513	1163	21	gonzález	gonzález	PROPN
admet-1513	1163	22	,	,	PUNCT
admet-1513	1163	23	n.	n.	PROPN
admet-1513	1163	24	castro	castro	PROPN
admet-1513	1163	25	,	,	PUNCT
admet-1513	1163	26	a.	a.	PROPN
admet-1513	1163	27	menendez	menendez	PROPN
admet-1513	1163	28	,	,	PUNCT
admet-1513	1163	29	s.	s.	PROPN
admet-1513	1163	30	kale	kale	PROPN
admet-1513	1163	31	,	,	PUNCT
admet-1513	1163	32	d.	d.	PROPN
admet-1513	1163	33	krndija	krndija	PROPN
admet-1513	1163	34	,	,	PUNCT
admet-1513	1163	35	a.g	a.g	PROPN
admet-1513	1163	36	.	.	PROPN
admet-1513	1163	37	clark	clark	PROPN
admet-1513	1163	38	,	,	PUNCT
admet-1513	1163	39	v.r	v.r	PROPN
admet-1513	1163	40	.	.	PROPN
admet-1513	1163	41	gannavarapu	gannavarapu	PROPN
admet-1513	1163	42	,	,	PUNCT
admet-1513	1163	43	a.	a.	PROPN
admet-1513	1163	44	álvarez	álvarez	PROPN
admet-1513	1163	45	-	-	PUNCT
admet-1513	1163	46	varela	varela	PROPN
admet-1513	1163	47	,	,	PUNCT
admet-1513	1163	48	p.	p.	PROPN
admet-1513	1163	49	roca	roca	PROPN
admet-1513	1163	50	-	-	PUNCT
admet-1513	1163	51	cusachs	cusachs	PROPN
admet-1513	1163	52	,	,	PUNCT
admet-1513	1163	53	e.	e.	PROPN
admet-1513	1163	54	batlle	batlle	PROPN
admet-1513	1163	55	,	,	PUNCT
admet-1513	1163	56	d.m	d.m	PROPN
admet-1513	1163	57	.	.	PROPN
admet-1513	1163	58	vignjevic	vignjevic	PROPN
admet-1513	1163	59	,	,	PUNCT
admet-1513	1163	60	m.	m.	NOUN
admet-1513	1163	61	arroyo	arroyo	PROPN
admet-1513	1163	62	,	,	PUNCT
admet-1513	1163	63	x.	x.	NOUN
admet-1513	1163	64	trepat	trepat	PROPN
admet-1513	1163	65	.	.	PUNCT
admet-1513	1164	1	mechanical	mechanical	ADJ
admet-1513	1164	2	compartmentalization	compartmentalization	NOUN
admet-1513	1164	3	of	of	ADP
admet-1513	1164	4	the	the	DET
admet-1513	1164	5	intestinal	intestinal	ADJ
admet-1513	1164	6	organoid	organoid	NOUN
admet-1513	1164	7	enables	enable	VERB
admet-1513	1164	8	crypt	crypt	NOUN
admet-1513	1164	9	folding	folding	NOUN
admet-1513	1164	10	and	and	CCONJ
admet-1513	1164	11	collective	collective	ADJ
admet-1513	1164	12	cell	cell	NOUN
admet-1513	1164	13	migration	migration	NOUN
admet-1513	1164	14	.	.	PUNCT
admet-1513	1165	1	nat	nat	NOUN
admet-1513	1165	2	.	.	PUNCT
admet-1513	1166	1	cell	cell	PROPN
admet-1513	1166	2	biol	biol	PROPN
admet-1513	1166	3	.	.	PUNCT
admet-1513	1167	1	23	23	NUM
admet-1513	1167	2	(	(	PUNCT
admet-1513	1167	3	2021	2021	NUM
admet-1513	1167	4	)	)	PUNCT
admet-1513	1167	5	745	745	NUM
admet-1513	1167	6	-	-	SYM
admet-1513	1167	7	757	757	NOUN
admet-1513	1167	8	.	.	PUNCT
admet-1513	1168	1	https://doi.org/10.1038/s41556-021-00699-6	https://doi.org/10.1038/s41556-021-00699-6	NUM
admet-1513	1168	2	.	.	PUNCT
admet-1513	1169	1	[	[	X
admet-1513	1169	2	127	127	NUM
admet-1513	1169	3	]	]	X
admet-1513	1169	4	q.	q.	PROPN
admet-1513	1169	5	yang	yang	PROPN
admet-1513	1169	6	,	,	PUNCT
admet-1513	1169	7	s.l	s.l	PROPN
admet-1513	1169	8	.	.	PROPN
admet-1513	1169	9	xue	xue	PROPN
admet-1513	1169	10	,	,	PUNCT
admet-1513	1169	11	c.j	c.j	PROPN
admet-1513	1169	12	.	.	PROPN
admet-1513	1169	13	chan	chan	PROPN
admet-1513	1169	14	,	,	PUNCT
admet-1513	1169	15	m.	m.	NOUN
admet-1513	1169	16	rempfler	rempfler	PROPN
admet-1513	1169	17	,	,	PUNCT
admet-1513	1169	18	d.	d.	PROPN
admet-1513	1169	19	vischi	vischi	PROPN
admet-1513	1169	20	,	,	PUNCT
admet-1513	1169	21	f.	f.	PROPN
admet-1513	1169	22	maurer	maurer	PROPN
admet-1513	1169	23	-	-	PUNCT
admet-1513	1169	24	gutierrez	gutierrez	PROPN
admet-1513	1169	25	,	,	PUNCT
admet-1513	1169	26	t.	t.	NOUN
admet-1513	1169	27	hiiragi	hiiragi	PROPN
admet-1513	1169	28	,	,	PUNCT
admet-1513	1169	29	e.	e.	PROPN
admet-1513	1169	30	hannezo	hannezo	PROPN
admet-1513	1169	31	,	,	PUNCT
admet-1513	1169	32	p.	p.	PROPN
admet-1513	1169	33	liberali	liberali	PROPN
admet-1513	1169	34	.	.	PUNCT
admet-1513	1170	1	cell	cell	NOUN
admet-1513	1170	2	fate	fate	NOUN
admet-1513	1170	3	coordinates	coordinate	NOUN
admet-1513	1170	4	mechano	mechano	PROPN
admet-1513	1170	5	-	-	ADJ
admet-1513	1170	6	osmotic	osmotic	ADJ
admet-1513	1170	7	forces	force	NOUN
admet-1513	1170	8	in	in	ADP
admet-1513	1170	9	intestinal	intestinal	ADJ
admet-1513	1170	10	crypt	crypt	NOUN
admet-1513	1170	11	formation	formation	NOUN
admet-1513	1170	12	.	.	PUNCT
admet-1513	1171	1	nat	nat	NOUN
admet-1513	1171	2	.	.	PUNCT
admet-1513	1172	1	cell	cell	PROPN
admet-1513	1172	2	biol	biol	PROPN
admet-1513	1172	3	.	.	PUNCT
admet-1513	1173	1	23	23	NUM
admet-1513	1173	2	(	(	PUNCT
admet-1513	1173	3	2021	2021	NUM
admet-1513	1173	4	)	)	PUNCT
admet-1513	1173	5	733	733	NUM
admet-1513	1173	6	-	-	SYM
admet-1513	1173	7	744	744	NUM
admet-1513	1173	8	.	.	PUNCT
admet-1513	1174	1	https://doi.org/10.1038/s41556-021-00700-2	https://doi.org/10.1038/s41556-021-00700-2	X
admet-1513	1174	2	.	.	PUNCT
admet-1513	1175	1	[	[	X
admet-1513	1175	2	128	128	NUM
admet-1513	1175	3	]	]	PUNCT
admet-1513	1175	4	l.	l.	PROPN
admet-1513	1175	5	lin	lin	PROPN
admet-1513	1175	6	,	,	PUNCT
admet-1513	1175	7	h.	h.	PROPN
admet-1513	1175	8	wong	wong	PROPN
admet-1513	1175	9	.	.	PROPN
admet-1513	1175	10	predicting	predict	VERB
admet-1513	1175	11	oral	oral	ADJ
admet-1513	1175	12	drug	drug	NOUN
admet-1513	1175	13	absorption	absorption	NOUN
admet-1513	1175	14	:	:	PUNCT
admet-1513	1175	15	mini	mini	ADJ
admet-1513	1175	16	review	review	NOUN
admet-1513	1175	17	on	on	ADP
admet-1513	1175	18	physiologically	physiologically	ADV
admet-1513	1175	19	-	-	PUNCT
admet-1513	1175	20	based	base	VERB
admet-1513	1175	21	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	1175	22	models	model	NOUN
admet-1513	1175	23	.	.	PUNCT
admet-1513	1176	1	pharmaceutics	pharmaceutic	NOUN
admet-1513	1176	2	9	9	NUM
admet-1513	1176	3	(	(	PUNCT
admet-1513	1176	4	2017	2017	NUM
admet-1513	1176	5	)	)	PUNCT
admet-1513	1176	6	e41	e41	NOUN
admet-1513	1176	7	.	.	PUNCT
admet-1513	1177	1	https://doi.org/10.3390/pharmaceutics9040041	https://doi.org/10.3390/pharmaceutics9040041	NOUN
admet-1513	1177	2	.	.	PUNCT
admet-1513	1178	1	[	[	X
admet-1513	1178	2	129	129	NUM
admet-1513	1178	3	]	]	X
admet-1513	1178	4	s.n	s.n	PROPN
admet-1513	1178	5	.	.	PROPN
admet-1513	1178	6	steinway	steinway	PROPN
admet-1513	1178	7	,	,	PUNCT
admet-1513	1178	8	j.	j.	PROPN
admet-1513	1178	9	saleh	saleh	PROPN
admet-1513	1178	10	,	,	PUNCT
admet-1513	1178	11	b.k	b.k	PROPN
admet-1513	1178	12	.	.	PROPN
admet-1513	1178	13	koo	koo	PROPN
admet-1513	1178	14	,	,	PUNCT
admet-1513	1178	15	d.	d.	PROPN
admet-1513	1178	16	delacour	delacour	PROPN
admet-1513	1178	17	,	,	PUNCT
admet-1513	1178	18	d.h	d.h	PROPN
admet-1513	1178	19	.	.	PROPN
admet-1513	1178	20	kim	kim	PROPN
admet-1513	1178	21	.	.	PUNCT
admet-1513	1179	1	human	human	ADJ
admet-1513	1179	2	microphysiological	microphysiological	ADJ
admet-1513	1179	3	models	model	NOUN
admet-1513	1179	4	of	of	ADP
admet-1513	1179	5	intestinal	intestinal	ADJ
admet-1513	1179	6	tissue	tissue	NOUN
admet-1513	1179	7	and	and	CCONJ
admet-1513	1179	8	gut	gut	NOUN
admet-1513	1179	9	microbiome	microbiome	NOUN
admet-1513	1179	10	.	.	PUNCT
admet-1513	1180	1	front	front	NOUN
admet-1513	1180	2	.	.	PUNCT
admet-1513	1181	1	bioeng	bioeng	PROPN
admet-1513	1181	2	.	.	PUNCT
admet-1513	1181	3	biotechnol	biotechnol	PROPN
admet-1513	1181	4	.	.	PUNCT
admet-1513	1182	1	8	8	NUM
admet-1513	1182	2	(	(	PUNCT
admet-1513	1182	3	2020	2020	NUM
admet-1513	1182	4	)	)	PUNCT
admet-1513	1183	1	725	725	X
admet-1513	1183	2	.	.	PUNCT
admet-1513	1184	1	https://doi.org/10.3389/fbioe.2020.00725	https://doi.org/10.3389/fbioe.2020.00725	PROPN
admet-1513	1184	2	.	.	PUNCT
admet-1513	1184	3	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	1184	4	https://doi.org/10.1016/j.biomaterials.2018.12.006	https://doi.org/10.1016/j.biomaterials.2018.12.006	PROPN
admet-1513	1184	5	https://doi.org/10.1016/j.biomaterials.2018.12.006	https://doi.org/10.1016/j.biomaterials.2018.12.006	PROPN
admet-1513	1184	6	https://doi.org/10.1016/j.jcmgh.2017.12.010	https://doi.org/10.1016/j.jcmgh.2017.12.010	NUM
admet-1513	1184	7	https://doi.org/10.1038/s41568-018-0104-6	https://doi.org/10.1038/s41568-018-0104-6	NUM
admet-1513	1185	1	https://doi.org/10.1038/nbt.2989	https://doi.org/10.1038/nbt.2989	PROPN
admet-1513	1185	2	https://doi.org/10.1172/jci.insight.86492	https://doi.org/10.1172/jci.insight.86492	PROPN
admet-1513	1185	3	https://doi.org/10.1172/jci.insight.86492	https://doi.org/10.1172/jci.insight.86492	PROPN
admet-1513	1185	4	https://doi.org/10.1038/srep16831	https://doi.org/10.1038/srep16831	PROPN
admet-1513	1185	5	https://doi.org/10.1016/j.jcmgh.2018.05.004	https://doi.org/10.1016/j.jcmgh.2018.05.004	PROPN
admet-1513	1185	6	https://doi.org/10.3389/fcimb.2020.00272	https://doi.org/10.3389/fcimb.2020.00272	PROPN
admet-1513	1185	7	https://doi.org/10.1016/j.devcel.2020.11.015	https://doi.org/10.1016/j.devcel.2020.11.015	PUNCT
admet-1513	1185	8	https://doi.org/10.1126/science.aaw9021	https://doi.org/10.1126/science.aaw9021	NOUN
admet-1513	1185	9	https://doi.org/10.1038/s41586-020-2724-8	https://doi.org/10.1038/s41586-020-2724-8	NUM
admet-1513	1185	10	https://doi.org/10.1038/s41556-021-00699-6	https://doi.org/10.1038/s41556-021-00699-6	NUM
admet-1513	1185	11	https://doi.org/10.1038/s41556-021-00699-6	https://doi.org/10.1038/s41556-021-00699-6	NUM
admet-1513	1185	12	https://doi.org/10.1038/s41556-021-00700-2	https://doi.org/10.1038/s41556-021-00700-2	NUM
admet-1513	1185	13	https://doi.org/10.3390/pharmaceutics9040041	https://doi.org/10.3390/pharmaceutics9040041	NOUN
admet-1513	1185	14	https://doi.org/10.3390/pharmaceutics9040041	https://doi.org/10.3390/pharmaceutics9040041	NOUN
admet-1513	1186	1	https://doi.org/10.3389/fbioe.2020.00725	https://doi.org/10.3389/fbioe.2020.00725	PROPN
admet-1513	1186	2	https://doi.org/10.3389/fbioe.2020.00725	https://doi.org/10.3389/fbioe.2020.00725	PROPN
admet-1513	1186	3	venkatesh	venkatesh	ADJ
admet-1513	1186	4	chunduri	chunduri	NOUN
admet-1513	1186	5	and	and	CCONJ
admet-1513	1186	6	srinivas	srinivas	PROPN
admet-1513	1186	7	maddi	maddi	PROPN
admet-1513	1186	8	admet	admet	PROPN
admet-1513	1186	9	&	&	CCONJ
admet-1513	1186	10	dmpk	dmpk	PROPN
admet-1513	1186	11	11(1	11(1	NUM
admet-1513	1186	12	)	)	PUNCT
admet-1513	1186	13	(	(	PUNCT
admet-1513	1186	14	2023	2023	NUM
admet-1513	1186	15	)	)	PUNCT
admet-1513	1186	16	1	1	NUM
admet-1513	1186	17	-	-	SYM
admet-1513	1186	18	32	32	NUM
admet-1513	1186	19	26	26	NUM
admet-1513	1186	20	[	[	X
admet-1513	1186	21	130	130	NUM
admet-1513	1186	22	]	]	SYM
admet-1513	1186	23	y.b	y.b	PROPN
admet-1513	1186	24	.	.	PROPN
admet-1513	1186	25	yin	yin	PROPN
admet-1513	1186	26	,	,	PUNCT
admet-1513	1186	27	h.r	h.r	PROPN
admet-1513	1186	28	.	.	PROPN
admet-1513	1186	29	de	de	PROPN
admet-1513	1186	30	jonge	jonge	PROPN
admet-1513	1186	31	,	,	PUNCT
admet-1513	1186	32	x.	x.	PROPN
admet-1513	1186	33	wu	wu	PROPN
admet-1513	1186	34	,	,	PUNCT
admet-1513	1186	35	y.l	y.l	PROPN
admet-1513	1186	36	.	.	PROPN
admet-1513	1186	37	yin	yin	PROPN
admet-1513	1186	38	.	.	PUNCT
admet-1513	1187	1	mini	mini	NOUN
admet-1513	1187	2	-	-	PUNCT
admet-1513	1187	3	gut	gut	ADJ
admet-1513	1187	4	:	:	PUNCT
admet-1513	1187	5	a	a	DET
admet-1513	1187	6	promising	promising	ADJ
admet-1513	1187	7	model	model	NOUN
admet-1513	1187	8	for	for	ADP
admet-1513	1187	9	drug	drug	NOUN
admet-1513	1187	10	development	development	NOUN
admet-1513	1187	11	.	.	PUNCT
admet-1513	1188	1	drug	drug	NOUN
admet-1513	1188	2	discov	discov	NOUN
admet-1513	1188	3	.	.	PUNCT
admet-1513	1189	1	today	today	NOUN
admet-1513	1189	2	24	24	NUM
admet-1513	1189	3	(	(	PUNCT
admet-1513	1189	4	2019	2019	NUM
admet-1513	1189	5	)	)	PUNCT
admet-1513	1189	6	1784	1784	NUM
admet-1513	1189	7	-	-	SYM
admet-1513	1189	8	1794	1794	NUM
admet-1513	1189	9	.	.	PUNCT
admet-1513	1190	1	https://doi.org/10.1016/j.drudis.2019.06.006	https://doi.org/10.1016/j.drudis.2019.06.006	NOUN
admet-1513	1190	2	.	.	PUNCT
admet-1513	1191	1	[	[	X
admet-1513	1191	2	131	131	NUM
admet-1513	1191	3	]	]	X
admet-1513	1191	4	n.	n.	PROPN
admet-1513	1191	5	sayed	sayed	PROPN
admet-1513	1191	6	,	,	PUNCT
admet-1513	1191	7	c.	c.	PROPN
admet-1513	1191	8	liu	liu	PROPN
admet-1513	1191	9	,	,	PUNCT
admet-1513	1191	10	j.c	j.c	PROPN
admet-1513	1191	11	.	.	PROPN
admet-1513	1191	12	wu	wu	PROPN
admet-1513	1191	13	.	.	PUNCT
admet-1513	1192	1	translation	translation	NOUN
admet-1513	1192	2	of	of	ADP
admet-1513	1192	3	human	human	NOUN
admet-1513	1192	4	-	-	PUNCT
admet-1513	1192	5	induced	induce	VERB
admet-1513	1192	6	pluripotent	pluripotent	ADJ
admet-1513	1192	7	stem	stem	NOUN
admet-1513	1192	8	cells	cell	NOUN
admet-1513	1192	9	:	:	PUNCT
admet-1513	1192	10	from	from	ADP
admet-1513	1192	11	clinical	clinical	ADJ
admet-1513	1192	12	trial	trial	NOUN
admet-1513	1192	13	in	in	ADP
admet-1513	1192	14	a	a	DET
admet-1513	1192	15	dish	dish	NOUN
admet-1513	1192	16	to	to	PART
admet-1513	1192	17	precision	precision	VERB
admet-1513	1192	18	medicine	medicine	NOUN
admet-1513	1192	19	.	.	PUNCT
admet-1513	1193	1	j.	j.	PROPN
admet-1513	1193	2	am	am	PROPN
admet-1513	1193	3	.	.	PUNCT
admet-1513	1194	1	coll	coll	PROPN
admet-1513	1194	2	.	.	PUNCT
admet-1513	1195	1	cardiol	cardiol	PROPN
admet-1513	1195	2	.	.	PUNCT
admet-1513	1196	1	67	67	NUM
admet-1513	1196	2	(	(	PUNCT
admet-1513	1196	3	2016	2016	NUM
admet-1513	1196	4	)	)	PUNCT
admet-1513	1196	5	2161	2161	NUM
admet-1513	1196	6	-	-	SYM
admet-1513	1196	7	2176	2176	NUM
admet-1513	1196	8	.	.	PUNCT
admet-1513	1197	1	https://doi.org/10.1016/j.jacc.2016.01.083	https://doi.org/10.1016/j.jacc.2016.01.083	PUNCT
admet-1513	1198	1	[	[	X
admet-1513	1198	2	132	132	NUM
admet-1513	1198	3	]	]	PUNCT
admet-1513	1198	4	a.	a.	NOUN
admet-1513	1198	5	carpentier	carpentier	PROPN
admet-1513	1198	6	,	,	PUNCT
admet-1513	1198	7	i.	i.	PROPN
admet-1513	1198	8	nimgaonkar	nimgaonkar	PROPN
admet-1513	1198	9	,	,	PUNCT
admet-1513	1198	10	v.	v.	PROPN
admet-1513	1198	11	chu	chu	PROPN
admet-1513	1198	12	,	,	PUNCT
admet-1513	1198	13	y.	y.	PROPN
admet-1513	1198	14	xia	xia	PROPN
admet-1513	1198	15	,	,	PUNCT
admet-1513	1198	16	z.	z.	PROPN
admet-1513	1198	17	hu	hu	PROPN
admet-1513	1198	18	,	,	PUNCT
admet-1513	1198	19	t.j	t.j	PROPN
admet-1513	1198	20	.	.	PROPN
admet-1513	1198	21	liang	liang	PROPN
admet-1513	1198	22	.	.	PUNCT
admet-1513	1199	1	hepatic	hepatic	ADJ
admet-1513	1199	2	differentiation	differentiation	NOUN
admet-1513	1199	3	of	of	ADP
admet-1513	1199	4	human	human	ADJ
admet-1513	1199	5	pluripotent	pluripotent	NOUN
admet-1513	1199	6	stem	stem	NOUN
admet-1513	1199	7	cells	cell	NOUN
admet-1513	1199	8	in	in	ADP
admet-1513	1199	9	miniaturized	miniaturized	ADJ
admet-1513	1199	10	format	format	NOUN
admet-1513	1199	11	suitable	suitable	ADJ
admet-1513	1199	12	for	for	ADP
admet-1513	1199	13	high	high	ADJ
admet-1513	1199	14	-	-	PUNCT
admet-1513	1199	15	throughput	throughput	NOUN
admet-1513	1199	16	screen	screen	NOUN
admet-1513	1199	17	.	.	PUNCT
admet-1513	1200	1	stem	stem	NOUN
admet-1513	1200	2	cell	cell	NOUN
admet-1513	1200	3	res	re	NOUN
admet-1513	1200	4	.	.	PUNCT
admet-1513	1201	1	16	16	NUM
admet-1513	1201	2	(	(	PUNCT
admet-1513	1201	3	2016	2016	NUM
admet-1513	1201	4	)	)	PUNCT
admet-1513	1201	5	640	640	NUM
admet-1513	1201	6	-	-	SYM
admet-1513	1201	7	650	650	NUM
admet-1513	1201	8	.	.	PUNCT
admet-1513	1202	1	https://doi.org/10.1016/j.scr.2016.03.009	https://doi.org/10.1016/j.scr.2016.03.009	X
admet-1513	1202	2	.	.	PUNCT
admet-1513	1203	1	[	[	X
admet-1513	1203	2	133	133	NUM
admet-1513	1203	3	]	]	SYM
admet-1513	1203	4	s.m	s.m	PROPN
admet-1513	1203	5	.	.	PROPN
admet-1513	1203	6	choi	choi	PROPN
admet-1513	1203	7	,	,	PUNCT
admet-1513	1203	8	y.	y.	PROPN
admet-1513	1203	9	kim	kim	PROPN
admet-1513	1203	10	,	,	PUNCT
admet-1513	1203	11	j.s	j.s	PROPN
admet-1513	1203	12	.	.	PROPN
admet-1513	1203	13	shim	shim	PROPN
admet-1513	1203	14	,	,	PUNCT
admet-1513	1203	15	j.t	j.t	PROPN
admet-1513	1203	16	.	.	PROPN
admet-1513	1203	17	park	park	PROPN
admet-1513	1203	18	,	,	PUNCT
admet-1513	1203	19	r.h	r.h	PROPN
admet-1513	1203	20	.	.	PROPN
admet-1513	1203	21	wang	wang	PROPN
admet-1513	1203	22	,	,	PUNCT
admet-1513	1203	23	s.d	s.d	PROPN
admet-1513	1203	24	.	.	PROPN
admet-1513	1203	25	leach	leach	NOUN
admet-1513	1203	26	,	,	PUNCT
admet-1513	1203	27	j.o	j.o	PROPN
admet-1513	1203	28	.	.	PROPN
admet-1513	1203	29	liu	liu	PROPN
admet-1513	1203	30	,	,	PUNCT
admet-1513	1203	31	c.	c.	PROPN
admet-1513	1203	32	deng	deng	PROPN
admet-1513	1203	33	,	,	PUNCT
admet-1513	1203	34	z.	z.	PROPN
admet-1513	1203	35	ye	ye	PROPN
admet-1513	1203	36	,	,	PUNCT
admet-1513	1203	37	y.y	y.y	PROPN
admet-1513	1203	38	.	.	PROPN
admet-1513	1203	39	jang	jang	PROPN
admet-1513	1203	40	.	.	PUNCT
admet-1513	1204	1	efficient	efficient	ADJ
admet-1513	1204	2	drug	drug	NOUN
admet-1513	1204	3	screening	screening	NOUN
admet-1513	1204	4	and	and	CCONJ
admet-1513	1204	5	gene	gene	NOUN
admet-1513	1204	6	correction	correction	NOUN
admet-1513	1204	7	for	for	ADP
admet-1513	1204	8	treating	treat	VERB
admet-1513	1204	9	liver	liver	NOUN
admet-1513	1204	10	disease	disease	NOUN
admet-1513	1204	11	using	use	VERB
admet-1513	1204	12	patient	patient	NOUN
admet-1513	1204	13	-	-	PUNCT
admet-1513	1204	14	specific	specific	ADJ
admet-1513	1204	15	stem	stem	NOUN
admet-1513	1204	16	cells	cell	NOUN
admet-1513	1204	17	.	.	PUNCT
admet-1513	1205	1	hepatology	hepatology	NOUN
admet-1513	1205	2	57	57	NUM
admet-1513	1205	3	(	(	PUNCT
admet-1513	1205	4	2013	2013	NUM
admet-1513	1205	5	)	)	PUNCT
admet-1513	1205	6	2458	2458	NUM
admet-1513	1205	7	-	-	SYM
admet-1513	1205	8	2468	2468	NUM
admet-1513	1205	9	.	.	PUNCT
admet-1513	1206	1	https://doi.org/10.1002/hep.26237	https://doi.org/10.1002/hep.26237	INTJ
admet-1513	1206	2	.	.	PUNCT
admet-1513	1207	1	[	[	X
admet-1513	1207	2	134	134	NUM
admet-1513	1207	3	]	]	X
admet-1513	1207	4	j.l	j.l	PROPN
admet-1513	1207	5	.	.	PROPN
admet-1513	1207	6	corbett	corbett	PROPN
admet-1513	1207	7	,	,	PUNCT
admet-1513	1207	8	s.a	s.a	PROPN
admet-1513	1207	9	.	.	PROPN
admet-1513	1207	10	duncan	duncan	PROPN
admet-1513	1207	11	.	.	PUNCT
admet-1513	1207	12	ipsc	ipsc	NOUN
admet-1513	1207	13	-	-	PUNCT
admet-1513	1207	14	derived	derive	VERB
admet-1513	1207	15	hepatocytes	hepatocyte	NOUN
admet-1513	1207	16	as	as	ADP
admet-1513	1207	17	a	a	DET
admet-1513	1207	18	platform	platform	NOUN
admet-1513	1207	19	for	for	ADP
admet-1513	1207	20	disease	disease	NOUN
admet-1513	1207	21	modeling	modeling	NOUN
admet-1513	1207	22	and	and	CCONJ
admet-1513	1207	23	drug	drug	NOUN
admet-1513	1207	24	discovery	discovery	NOUN
admet-1513	1207	25	.	.	PUNCT
admet-1513	1208	1	front	front	NOUN
admet-1513	1208	2	.	.	PUNCT
admet-1513	1209	1	med	med	PROPN
admet-1513	1209	2	.	.	PUNCT
admet-1513	1210	1	(	(	PUNCT
admet-1513	1210	2	lausanne	lausanne	PROPN
admet-1513	1210	3	)	)	PUNCT
admet-1513	1210	4	6	6	NUM
admet-1513	1210	5	(	(	PUNCT
admet-1513	1210	6	2019	2019	NUM
admet-1513	1210	7	)	)	PUNCT
admet-1513	1210	8	265	265	NUM
admet-1513	1210	9	.	.	PUNCT
admet-1513	1211	1	https://doi.org/10.3389/fmed.2019.00265	https://doi.org/10.3389/fmed.2019.00265	VERB
admet-1513	1211	2	[	[	X
admet-1513	1211	3	135	135	NUM
admet-1513	1211	4	]	]	X
admet-1513	1211	5	j.p	j.p	PROPN
admet-1513	1211	6	.	.	PROPN
admet-1513	1211	7	cotovio	cotovio	PROPN
admet-1513	1211	8	,	,	PUNCT
admet-1513	1211	9	t.g	t.g	PROPN
admet-1513	1211	10	.	.	PROPN
admet-1513	1211	11	fernandes	fernandes	PROPN
admet-1513	1211	12	.	.	PUNCT
admet-1513	1212	1	production	production	NOUN
admet-1513	1212	2	of	of	ADP
admet-1513	1212	3	human	human	ADJ
admet-1513	1212	4	pluripotent	pluripotent	NOUN
admet-1513	1212	5	stem	stem	NOUN
admet-1513	1212	6	cell	cell	NOUN
admet-1513	1212	7	-	-	PUNCT
admet-1513	1212	8	derived	derive	VERB
admet-1513	1212	9	hepatic	hepatic	ADJ
admet-1513	1212	10	cell	cell	NOUN
admet-1513	1212	11	lineages	lineage	NOUN
admet-1513	1212	12	and	and	CCONJ
admet-1513	1212	13	liver	liver	NOUN
admet-1513	1212	14	organoids	organoid	NOUN
admet-1513	1212	15	:	:	PUNCT
admet-1513	1212	16	current	current	ADJ
admet-1513	1212	17	status	status	NOUN
admet-1513	1212	18	and	and	CCONJ
admet-1513	1212	19	potential	potential	ADJ
admet-1513	1212	20	applications	application	NOUN
admet-1513	1212	21	.	.	PUNCT
admet-1513	1213	1	bioengineering	bioengineering	NOUN
admet-1513	1213	2	(	(	PUNCT
admet-1513	1213	3	basel	basel	PROPN
admet-1513	1213	4	)	)	PUNCT
admet-1513	1213	5	7	7	NUM
admet-1513	1213	6	(	(	PUNCT
admet-1513	1213	7	2020	2020	NUM
admet-1513	1213	8	)	)	PUNCT
admet-1513	1213	9	e36	e36	PROPN
admet-1513	1213	10	.	.	PUNCT
admet-1513	1214	1	https://doi.org/10.3390/bioengineering7020036	https://doi.org/10.3390/bioengineering7020036	PROPN
admet-1513	1214	2	.	.	PUNCT
admet-1513	1215	1	[	[	X
admet-1513	1215	2	136	136	NUM
admet-1513	1215	3	]	]	X
admet-1513	1215	4	m.a	m.a	PROPN
admet-1513	1215	5	.	.	PROPN
admet-1513	1215	6	cayo	cayo	PROPN
admet-1513	1215	7	,	,	PUNCT
admet-1513	1215	8	s.k	s.k	PROPN
admet-1513	1215	9	.	.	PROPN
admet-1513	1215	10	mallanna	mallanna	PROPN
admet-1513	1215	11	,	,	PUNCT
admet-1513	1215	12	f.	f.	PROPN
admet-1513	1215	13	di	di	PROPN
admet-1513	1215	14	furio	furio	PROPN
admet-1513	1215	15	,	,	PUNCT
admet-1513	1215	16	r.	r.	PROPN
admet-1513	1215	17	jing	jing	PROPN
admet-1513	1215	18	,	,	PUNCT
admet-1513	1215	19	l.b	l.b	PROPN
admet-1513	1215	20	.	.	PROPN
admet-1513	1215	21	tolliver	tolliver	PROPN
admet-1513	1215	22	,	,	PUNCT
admet-1513	1215	23	m.	m.	NOUN
admet-1513	1215	24	bures	bure	NOUN
admet-1513	1215	25	,	,	PUNCT
admet-1513	1215	26	a.	a.	NOUN
admet-1513	1215	27	urick	urick	PROPN
admet-1513	1215	28	,	,	PUNCT
admet-1513	1215	29	f.k	f.k	PROPN
admet-1513	1215	30	.	.	PROPN
admet-1513	1215	31	noto	noto	PROPN
admet-1513	1215	32	,	,	PUNCT
admet-1513	1215	33	e.e	e.e	PROPN
admet-1513	1215	34	.	.	PROPN
admet-1513	1215	35	pashos	pashos	PROPN
admet-1513	1215	36	,	,	PUNCT
admet-1513	1215	37	m.d	m.d	PROPN
admet-1513	1215	38	.	.	PROPN
admet-1513	1215	39	greseth	greseth	PROPN
admet-1513	1215	40	,	,	PUNCT
admet-1513	1215	41	m.	m.	PROPN
admet-1513	1215	42	czarnecki	czarnecki	PROPN
admet-1513	1215	43	,	,	PUNCT
admet-1513	1215	44	p.	p.	NOUN
admet-1513	1215	45	traktman	traktman	PROPN
admet-1513	1215	46	,	,	PUNCT
admet-1513	1215	47	w.	w.	PROPN
admet-1513	1215	48	yang	yang	PROPN
admet-1513	1215	49	,	,	PUNCT
admet-1513	1215	50	e.e	e.e	PROPN
admet-1513	1215	51	.	.	PROPN
admet-1513	1215	52	morrisey	morrisey	PROPN
admet-1513	1215	53	,	,	PUNCT
admet-1513	1215	54	m.	m.	NOUN
admet-1513	1215	55	grompe	grompe	PROPN
admet-1513	1215	56	,	,	PUNCT
admet-1513	1215	57	d.j	d.j	PROPN
admet-1513	1215	58	.	.	PROPN
admet-1513	1215	59	rader	rader	PROPN
admet-1513	1215	60	,	,	PUNCT
admet-1513	1215	61	s.a	s.a	PROPN
admet-1513	1215	62	.	.	PROPN
admet-1513	1215	63	duncan	duncan	PROPN
admet-1513	1215	64	.	.	PUNCT
admet-1513	1216	1	a	a	DET
admet-1513	1216	2	drug	drug	NOUN
admet-1513	1216	3	screen	screen	NOUN
admet-1513	1216	4	using	use	VERB
admet-1513	1216	5	human	human	ADJ
admet-1513	1216	6	ipsc	ipsc	NOUN
admet-1513	1216	7	-	-	PUNCT
admet-1513	1216	8	derived	derive	VERB
admet-1513	1216	9	hepatocyte	hepatocyte	NOUN
admet-1513	1216	10	-	-	PUNCT
admet-1513	1216	11	like	like	ADJ
admet-1513	1216	12	cells	cell	NOUN
admet-1513	1216	13	reveals	reveal	VERB
admet-1513	1216	14	cardiac	cardiac	ADJ
admet-1513	1216	15	glycosides	glycoside	NOUN
admet-1513	1216	16	as	as	ADP
admet-1513	1216	17	a	a	DET
admet-1513	1216	18	potential	potential	ADJ
admet-1513	1216	19	treatment	treatment	NOUN
admet-1513	1216	20	for	for	ADP
admet-1513	1216	21	hypercholesterolemia	hypercholesterolemia	NOUN
admet-1513	1216	22	.	.	PUNCT
admet-1513	1217	1	cell	cell	NOUN
admet-1513	1217	2	stem	stem	NOUN
admet-1513	1217	3	cell	cell	NOUN
admet-1513	1217	4	20	20	NUM
admet-1513	1217	5	(	(	PUNCT
admet-1513	1217	6	2017	2017	NUM
admet-1513	1217	7	)	)	PUNCT
admet-1513	1217	8	478	478	NUM
admet-1513	1217	9	-	-	NUM
admet-1513	1217	10	489.e5	489.e5	NOUN
admet-1513	1217	11	.	.	PUNCT
admet-1513	1218	1	https://doi.org/10.1016/j.stem.2017.01.011	https://doi.org/10.1016/j.stem.2017.01.011	NOUN
admet-1513	1218	2	.	.	PUNCT
admet-1513	1219	1	[	[	X
admet-1513	1219	2	137	137	NUM
admet-1513	1219	3	]	]	PUNCT
admet-1513	1219	4	r.	r.	PROPN
admet-1513	1219	5	jing	jing	PROPN
admet-1513	1219	6	,	,	PUNCT
admet-1513	1219	7	j.l	j.l	PROPN
admet-1513	1219	8	.	.	PROPN
admet-1513	1219	9	corbett	corbett	PROPN
admet-1513	1219	10	,	,	PUNCT
admet-1513	1219	11	j.	j.	PROPN
admet-1513	1219	12	cai	cai	PROPN
admet-1513	1219	13	,	,	PUNCT
admet-1513	1219	14	g.c	g.c	PROPN
admet-1513	1219	15	.	.	PROPN
admet-1513	1219	16	beeson	beeson	PROPN
admet-1513	1219	17	,	,	PUNCT
admet-1513	1219	18	c.c	c.c	PROPN
admet-1513	1219	19	.	.	PROPN
admet-1513	1219	20	beeson	beeson	PROPN
admet-1513	1219	21	,	,	PUNCT
admet-1513	1219	22	s.s	s.s	PROPN
admet-1513	1219	23	.	.	PROPN
admet-1513	1219	24	chan	chan	PROPN
admet-1513	1219	25	,	,	PUNCT
admet-1513	1219	26	d.p	d.p	PROPN
admet-1513	1219	27	.	.	PROPN
admet-1513	1219	28	dimmock	dimmock	PROPN
admet-1513	1219	29	,	,	PUNCT
admet-1513	1219	30	l.	l.	PROPN
admet-1513	1219	31	lazcares	lazcares	PROPN
admet-1513	1219	32	,	,	PUNCT
admet-1513	1219	33	a.m.	a.m.	PROPN
admet-1513	1219	34	geurts	geurts	PROPN
admet-1513	1219	35	,	,	PUNCT
admet-1513	1219	36	j.j	j.j	PROPN
admet-1513	1219	37	.	.	PROPN
admet-1513	1219	38	lemasters	lemaster	NOUN
admet-1513	1219	39	,	,	PUNCT
admet-1513	1219	40	s.a	s.a	PROPN
admet-1513	1219	41	.	.	PROPN
admet-1513	1219	42	duncan	duncan	PROPN
admet-1513	1219	43	.	.	PUNCT
admet-1513	1220	1	a	a	DET
admet-1513	1220	2	screen	screen	NOUN
admet-1513	1220	3	using	use	VERB
admet-1513	1220	4	ipsc	ipsc	NOUN
admet-1513	1220	5	-	-	PUNCT
admet-1513	1220	6	derived	derive	VERB
admet-1513	1220	7	hepatocytes	hepatocyte	NOUN
admet-1513	1220	8	reveals	reveal	VERB
admet-1513	1220	9	nad+	nad+	PROPN
admet-1513	1220	10	as	as	ADP
admet-1513	1220	11	a	a	DET
admet-1513	1220	12	potential	potential	ADJ
admet-1513	1220	13	treatment	treatment	NOUN
admet-1513	1220	14	for	for	ADP
admet-1513	1220	15	mtdna	mtdna	NOUN
admet-1513	1220	16	depletion	depletion	NOUN
admet-1513	1220	17	syndrome	syndrome	NOUN
admet-1513	1220	18	.	.	PUNCT
admet-1513	1221	1	cell	cell	NOUN
admet-1513	1221	2	rep	rep	PROPN
admet-1513	1221	3	.	.	PROPN
admet-1513	1221	4	25	25	NUM
admet-1513	1221	5	(	(	PUNCT
admet-1513	1221	6	2018	2018	NUM
admet-1513	1221	7	)	)	PUNCT
admet-1513	1221	8	1469	1469	NUM
admet-1513	1221	9	-	-	SYM
admet-1513	1221	10	1484.e5	1484.e5	NUM
admet-1513	1221	11	.	.	PUNCT
admet-1513	1221	12	https://doi.org/10.1016/j.celrep.2018.10.036	https://doi.org/10.1016/j.celrep.2018.10.036	PROPN
admet-1513	1221	13	.	.	PUNCT
admet-1513	1222	1	[	[	X
admet-1513	1222	2	138	138	NUM
admet-1513	1222	3	]	]	X
admet-1513	1222	4	c.n	c.n	PROPN
admet-1513	1222	5	.	.	PROPN
admet-1513	1222	6	medine	medine	PROPN
admet-1513	1222	7	,	,	PUNCT
admet-1513	1222	8	b.	b.	PROPN
admet-1513	1222	9	lucendo	lucendo	PROPN
admet-1513	1222	10	-	-	PUNCT
admet-1513	1222	11	villarin	villarin	PROPN
admet-1513	1222	12	,	,	PUNCT
admet-1513	1222	13	c.	c.	PROPN
admet-1513	1222	14	storck	storck	PROPN
admet-1513	1222	15	,	,	PUNCT
admet-1513	1222	16	f.	f.	PROPN
admet-1513	1222	17	wang	wang	PROPN
admet-1513	1222	18	,	,	PUNCT
admet-1513	1222	19	d.	d.	PROPN
admet-1513	1222	20	szkolnicka	szkolnicka	PROPN
admet-1513	1222	21	,	,	PUNCT
admet-1513	1222	22	f.	f.	PROPN
admet-1513	1222	23	khan	khan	PROPN
admet-1513	1222	24	,	,	PUNCT
admet-1513	1222	25	s.	s.	PROPN
admet-1513	1222	26	pernagallo	pernagallo	PROPN
admet-1513	1222	27	,	,	PUNCT
admet-1513	1222	28	j.r	j.r	PROPN
admet-1513	1222	29	.	.	PROPN
admet-1513	1222	30	black	black	PROPN
admet-1513	1222	31	,	,	PUNCT
admet-1513	1222	32	h.m	h.m	PROPN
admet-1513	1222	33	.	.	PROPN
admet-1513	1222	34	marriage	marriage	NOUN
admet-1513	1222	35	,	,	PUNCT
admet-1513	1222	36	j.a	j.a	PROPN
admet-1513	1222	37	.	.	PROPN
admet-1513	1222	38	ross	ross	PROPN
admet-1513	1222	39	,	,	PUNCT
admet-1513	1222	40	m.	m.	PROPN
admet-1513	1222	41	bradley	bradley	PROPN
admet-1513	1222	42	,	,	PUNCT
admet-1513	1222	43	j.p	j.p	PROPN
admet-1513	1222	44	.	.	PROPN
admet-1513	1222	45	iredale	iredale	PROPN
admet-1513	1222	46	,	,	PUNCT
admet-1513	1222	47	o.	o.	PROPN
admet-1513	1222	48	flint	flint	PROPN
admet-1513	1222	49	,	,	PUNCT
admet-1513	1222	50	d.c	d.c	PROPN
admet-1513	1222	51	.	.	PUNCT
admet-1513	1222	52	hay	hay	PROPN
admet-1513	1222	53	.	.	PUNCT
admet-1513	1223	1	developing	develop	VERB
admet-1513	1223	2	high	high	ADJ
admet-1513	1223	3	-	-	PUNCT
admet-1513	1223	4	fidelity	fidelity	NOUN
admet-1513	1223	5	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	1223	6	models	model	NOUN
admet-1513	1223	7	from	from	ADP
admet-1513	1223	8	pluripotent	pluripotent	ADJ
admet-1513	1223	9	stem	stem	NOUN
admet-1513	1223	10	cells	cell	NOUN
admet-1513	1223	11	.	.	PUNCT
admet-1513	1224	1	stem	stem	NOUN
admet-1513	1224	2	cells	cell	NOUN
admet-1513	1224	3	transl	transl	PROPN
admet-1513	1224	4	.	.	PUNCT
admet-1513	1225	1	med	med	PROPN
admet-1513	1225	2	.	.	PROPN
admet-1513	1225	3	2	2	NUM
admet-1513	1225	4	(	(	PUNCT
admet-1513	1225	5	2013	2013	NUM
admet-1513	1225	6	)	)	PUNCT
admet-1513	1225	7	505	505	NUM
admet-1513	1225	8	-	-	SYM
admet-1513	1225	9	509	509	NUM
admet-1513	1225	10	.	.	PUNCT
admet-1513	1226	1	https://doi.org/10.5966/sctm.2012-0138	https://doi.org/10.5966/sctm.2012-0138	PROPN
admet-1513	1226	2	.	.	PUNCT
admet-1513	1227	1	[	[	X
admet-1513	1227	2	139	139	NUM
admet-1513	1227	3	]	]	X
admet-1513	1227	4	o.	o.	PROPN
admet-1513	1227	5	sirenko	sirenko	PROPN
admet-1513	1227	6	,	,	PUNCT
admet-1513	1227	7	m.k	m.k	PROPN
admet-1513	1227	8	.	.	PUNCT
admet-1513	1227	9	hancock	hancock	PROPN
admet-1513	1227	10	,	,	PUNCT
admet-1513	1227	11	j.	j.	PROPN
admet-1513	1227	12	hesley	hesley	PROPN
admet-1513	1227	13	,	,	PUNCT
admet-1513	1227	14	d.	d.	PROPN
admet-1513	1227	15	hong	hong	PROPN
admet-1513	1227	16	,	,	PUNCT
admet-1513	1227	17	a.	a.	PROPN
admet-1513	1227	18	cohen	cohen	PROPN
admet-1513	1227	19	,	,	PUNCT
admet-1513	1227	20	j.	j.	PROPN
admet-1513	1227	21	gentry	gentry	PROPN
admet-1513	1227	22	,	,	PUNCT
admet-1513	1227	23	c.b	c.b	PROPN
admet-1513	1227	24	.	.	PROPN
admet-1513	1227	25	carlson	carlson	PROPN
admet-1513	1227	26	,	,	PUNCT
admet-1513	1227	27	d.a	d.a	PROPN
admet-1513	1227	28	.	.	PROPN
admet-1513	1227	29	mann	mann	PROPN
admet-1513	1227	30	.	.	PUNCT
admet-1513	1228	1	phenotypic	phenotypic	ADJ
admet-1513	1228	2	characterization	characterization	NOUN
admet-1513	1228	3	of	of	ADP
admet-1513	1228	4	toxic	toxic	ADJ
admet-1513	1228	5	compound	compound	NOUN
admet-1513	1228	6	effects	effect	NOUN
admet-1513	1228	7	on	on	ADP
admet-1513	1228	8	liver	liver	NOUN
admet-1513	1228	9	spheroids	spheroid	NOUN
admet-1513	1228	10	derived	derive	VERB
admet-1513	1228	11	from	from	ADP
admet-1513	1228	12	ipsc	ipsc	NOUN
admet-1513	1228	13	using	use	VERB
admet-1513	1228	14	confocal	confocal	ADJ
admet-1513	1228	15	imaging	imaging	NOUN
admet-1513	1228	16	and	and	CCONJ
admet-1513	1228	17	three	three	NUM
admet-1513	1228	18	-	-	PUNCT
admet-1513	1228	19	dimensional	dimensional	ADJ
admet-1513	1228	20	image	image	NOUN
admet-1513	1228	21	analysis	analysis	NOUN
admet-1513	1228	22	.	.	PUNCT
admet-1513	1229	1	assay	assay	PROPN
admet-1513	1229	2	.	.	PUNCT
admet-1513	1230	1	drug	drug	PROPN
admet-1513	1230	2	dev	dev	PROPN
admet-1513	1230	3	.	.	PUNCT
admet-1513	1231	1	technol	technol	PROPN
admet-1513	1231	2	.	.	PUNCT
admet-1513	1232	1	14	14	NUM
admet-1513	1232	2	(	(	PUNCT
admet-1513	1232	3	2016	2016	NUM
admet-1513	1232	4	)	)	PUNCT
admet-1513	1232	5	381	381	NUM
admet-1513	1232	6	-	-	SYM
admet-1513	1232	7	394	394	NUM
admet-1513	1232	8	.	.	PUNCT
admet-1513	1233	1	https://doi.org/10.1089/adt.2016.729	https://doi.org/10.1089/adt.2016.729	PROPN
admet-1513	1233	2	.	.	PUNCT
admet-1513	1234	1	[	[	X
admet-1513	1234	2	140	140	NUM
admet-1513	1234	3	]	]	X
admet-1513	1234	4	b.r	b.r	PROPN
admet-1513	1234	5	.	.	PROPN
admet-1513	1234	6	ware	ware	PROPN
admet-1513	1234	7	,	,	PUNCT
admet-1513	1234	8	d.r	d.r	PROPN
admet-1513	1234	9	.	.	PROPN
admet-1513	1234	10	berger	berger	PROPN
admet-1513	1234	11	,	,	PUNCT
admet-1513	1234	12	s.r	s.r	PROPN
admet-1513	1234	13	.	.	PROPN
admet-1513	1234	14	khetani	khetani	PROPN
admet-1513	1234	15	.	.	PUNCT
admet-1513	1235	1	prediction	prediction	NOUN
admet-1513	1235	2	of	of	ADP
admet-1513	1235	3	drug	drug	NOUN
admet-1513	1235	4	-	-	PUNCT
admet-1513	1235	5	induced	induce	VERB
admet-1513	1235	6	liver	liver	NOUN
admet-1513	1235	7	injury	injury	NOUN
admet-1513	1235	8	in	in	ADP
admet-1513	1235	9	micropatterned	micropatterne	VERB
admet-1513	1235	10	cocultures	coculture	NOUN
admet-1513	1235	11	containing	contain	VERB
admet-1513	1235	12	ipsc	ipsc	NOUN
admet-1513	1235	13	-	-	PUNCT
admet-1513	1235	14	derived	derive	VERB
admet-1513	1235	15	human	human	ADJ
admet-1513	1235	16	hepatocytes	hepatocyte	NOUN
admet-1513	1235	17	.	.	PUNCT
admet-1513	1236	1	toxicol	toxicol	PROPN
admet-1513	1236	2	.	.	PUNCT
admet-1513	1237	1	sci	sci	PROPN
admet-1513	1237	2	.	.	PROPN
admet-1513	1238	1	145	145	NUM
admet-1513	1238	2	(	(	PUNCT
admet-1513	1238	3	2015	2015	NUM
admet-1513	1238	4	)	)	PUNCT
admet-1513	1238	5	252	252	NUM
admet-1513	1238	6	-	-	SYM
admet-1513	1238	7	262	262	NUM
admet-1513	1238	8	.	.	PUNCT
admet-1513	1238	9	https://doi.org/10.1093/toxsci/kfv048	https://doi.org/10.1093/toxsci/kfv048	NOUN
admet-1513	1238	10	.	.	PUNCT
admet-1513	1239	1	[	[	X
admet-1513	1239	2	141	141	NUM
admet-1513	1239	3	]	]	PUNCT
admet-1513	1239	4	x.	x.	NOUN
admet-1513	1239	5	yin	yin	PROPN
admet-1513	1239	6	,	,	PUNCT
admet-1513	1239	7	b.e	b.e	PROPN
admet-1513	1239	8	.	.	PROPN
admet-1513	1239	9	mead	mead	PROPN
admet-1513	1239	10	,	,	PUNCT
admet-1513	1239	11	h.	h.	PROPN
admet-1513	1239	12	safaee	safaee	PROPN
admet-1513	1239	13	,	,	PUNCT
admet-1513	1239	14	r.	r.	PROPN
admet-1513	1239	15	langer	langer	PROPN
admet-1513	1239	16	,	,	PUNCT
admet-1513	1239	17	j.m	j.m	PROPN
admet-1513	1239	18	.	.	PROPN
admet-1513	1239	19	karp	karp	PROPN
admet-1513	1239	20	,	,	PUNCT
admet-1513	1239	21	o.	o.	PROPN
admet-1513	1239	22	levy	levy	NOUN
admet-1513	1239	23	.	.	PUNCT
admet-1513	1240	1	engineering	engineering	NOUN
admet-1513	1240	2	stem	stem	NOUN
admet-1513	1240	3	cell	cell	NOUN
admet-1513	1240	4	organoids	organoid	NOUN
admet-1513	1240	5	.	.	PUNCT
admet-1513	1241	1	cell	cell	NOUN
admet-1513	1241	2	stem	stem	NOUN
admet-1513	1241	3	cell	cell	NOUN
admet-1513	1241	4	18	18	NUM
admet-1513	1241	5	(	(	PUNCT
admet-1513	1241	6	2016	2016	NUM
admet-1513	1241	7	)	)	PUNCT
admet-1513	1241	8	25	25	NUM
admet-1513	1241	9	-	-	SYM
admet-1513	1241	10	38	38	NUM
admet-1513	1241	11	.	.	PUNCT
admet-1513	1242	1	https://doi.org/10.1016/j.stem.2015.12.005	https://doi.org/10.1016/j.stem.2015.12.005	NOUN
admet-1513	1242	2	.	.	PUNCT
admet-1513	1243	1	[	[	X
admet-1513	1243	2	142	142	NUM
admet-1513	1243	3	]	]	X
admet-1513	1243	4	t.p	t.p	PROPN
admet-1513	1243	5	.	.	PROPN
admet-1513	1243	6	silva	silva	PROPN
admet-1513	1243	7	,	,	PUNCT
admet-1513	1243	8	j.p	j.p	PROPN
admet-1513	1243	9	.	.	PROPN
admet-1513	1243	10	cotovio	cotovio	PROPN
admet-1513	1243	11	,	,	PUNCT
admet-1513	1243	12	e.	e.	PROPN
admet-1513	1243	13	bekman	bekman	PROPN
admet-1513	1243	14	,	,	PUNCT
admet-1513	1243	15	m.	m.	PROPN
admet-1513	1243	16	carmo	carmo	PROPN
admet-1513	1243	17	-	-	PUNCT
admet-1513	1243	18	fonseca	fonseca	PROPN
admet-1513	1243	19	,	,	PUNCT
admet-1513	1243	20	j.m.s	j.m.s	PROPN
admet-1513	1243	21	.	.	PUNCT
admet-1513	1244	1	cabral	cabral	PROPN
admet-1513	1244	2	,	,	PUNCT
admet-1513	1244	3	t.g	t.g	PROPN
admet-1513	1244	4	.	.	PROPN
admet-1513	1244	5	fernandes	fernandes	PROPN
admet-1513	1244	6	.	.	PUNCT
admet-1513	1245	1	design	design	NOUN
admet-1513	1245	2	principles	principle	NOUN
admet-1513	1245	3	for	for	ADP
admet-1513	1245	4	pluripotent	pluripotent	ADJ
admet-1513	1245	5	stem	stem	NOUN
admet-1513	1245	6	cell	cell	NOUN
admet-1513	1245	7	-	-	PUNCT
admet-1513	1245	8	derived	derive	VERB
admet-1513	1245	9	organoid	organoid	NOUN
admet-1513	1245	10	engineering	engineering	NOUN
admet-1513	1245	11	.	.	PUNCT
admet-1513	1246	1	stem	stem	NOUN
admet-1513	1246	2	cells	cell	NOUN
admet-1513	1246	3	int	int	NOUN
admet-1513	1246	4	.	.	PUNCT
admet-1513	1247	1	2019	2019	NUM
admet-1513	1247	2	(	(	PUNCT
admet-1513	1247	3	2019	2019	NUM
admet-1513	1247	4	)	)	PUNCT
admet-1513	1247	5	4508470	4508470	NUM
admet-1513	1247	6	.	.	PUNCT
admet-1513	1248	1	https://doi.org/10.1155/2019/4508470	https://doi.org/10.1155/2019/4508470	PROPN
admet-1513	1248	2	.	.	PUNCT
admet-1513	1249	1	[	[	X
admet-1513	1249	2	143	143	X
admet-1513	1249	3	]	]	X
admet-1513	1249	4	j.	j.	PROPN
admet-1513	1249	5	poisson	poisson	PROPN
admet-1513	1249	6	,	,	PUNCT
admet-1513	1249	7	s.	s.	PROPN
admet-1513	1249	8	lemoinne	lemoinne	PROPN
admet-1513	1249	9	,	,	PUNCT
admet-1513	1249	10	c.	c.	PROPN
admet-1513	1249	11	boulanger	boulanger	PROPN
admet-1513	1249	12	,	,	PUNCT
admet-1513	1249	13	f.	f.	PROPN
admet-1513	1249	14	durand	durand	PROPN
admet-1513	1249	15	,	,	PUNCT
admet-1513	1249	16	r.	r.	PROPN
admet-1513	1249	17	moreau	moreau	PROPN
admet-1513	1249	18	,	,	PUNCT
admet-1513	1249	19	d.	d.	PROPN
admet-1513	1249	20	valla	valla	PROPN
admet-1513	1249	21	,	,	PUNCT
admet-1513	1249	22	p.e	p.e	PROPN
admet-1513	1249	23	.	.	PROPN
admet-1513	1249	24	rautou	rautou	PROPN
admet-1513	1249	25	.	.	PUNCT
admet-1513	1250	1	liver	liver	NOUN
admet-1513	1250	2	sinusoidal	sinusoidal	ADJ
admet-1513	1250	3	endothelial	endothelial	ADJ
admet-1513	1250	4	cells	cell	NOUN
admet-1513	1250	5	:	:	PUNCT
admet-1513	1250	6	physiology	physiology	NOUN
admet-1513	1250	7	and	and	CCONJ
admet-1513	1250	8	role	role	NOUN
admet-1513	1250	9	in	in	ADP
admet-1513	1250	10	liver	liver	NOUN
admet-1513	1250	11	diseases	disease	NOUN
admet-1513	1250	12	.	.	PUNCT
admet-1513	1251	1	j.	j.	PROPN
admet-1513	1251	2	hepatol	hepatol	PROPN
admet-1513	1251	3	.	.	PUNCT
admet-1513	1252	1	66	66	NUM
admet-1513	1252	2	(	(	PUNCT
admet-1513	1252	3	2017	2017	NUM
admet-1513	1252	4	)	)	PUNCT
admet-1513	1252	5	212	212	NUM
admet-1513	1252	6	-	-	SYM
admet-1513	1252	7	227	227	NUM
admet-1513	1252	8	.	.	PUNCT
admet-1513	1253	1	https://doi.org/10.1016/j.jhep.2016.07.009	https://doi.org/10.1016/j.jhep.2016.07.009	PROPN
admet-1513	1253	2	.	.	PUNCT
admet-1513	1254	1	https://doi.org/10.1016/j.drudis.2019.06.006	https://doi.org/10.1016/j.drudis.2019.06.006	PROPN
admet-1513	1254	2	https://doi.org/10.1016/j.jacc.2016.01.083	https://doi.org/10.1016/j.jacc.2016.01.083	PROPN
admet-1513	1254	3	https://doi.org/10.1016/j.jacc.2016.01.083	https://doi.org/10.1016/j.jacc.2016.01.083	NUM
admet-1513	1254	4	https://doi.org/10.1016/j.scr.2016.03.009	https://doi.org/10.1016/j.scr.2016.03.009	NOUN
admet-1513	1255	1	https://doi.org/10.1002/hep.26237	https://doi.org/10.1002/hep.26237	PROPN
admet-1513	1255	2	https://doi.org/10.3389/fmed.2019.00265	https://doi.org/10.3389/fmed.2019.00265	PROPN
admet-1513	1255	3	https://doi.org/10.3390/bioengineering7020036	https://doi.org/10.3390/bioengineering7020036	NOUN
admet-1513	1255	4	https://doi.org/10.1016/j.stem.2017.01.011	https://doi.org/10.1016/j.stem.2017.01.011	PROPN
admet-1513	1255	5	https://doi.org/10.1016/j.stem.2017.01.011	https://doi.org/10.1016/j.stem.2017.01.011	PROPN
admet-1513	1255	6	https://doi.org/10.1016/j.celrep.2018.10.036	https://doi.org/10.1016/j.celrep.2018.10.036	NOUN
admet-1513	1255	7	https://doi.org/10.1016/j.celrep.2018.10.036	https://doi.org/10.1016/j.celrep.2018.10.036	NOUN
admet-1513	1255	8	https://doi.org/10.5966/sctm.2012-0138	https://doi.org/10.5966/sctm.2012-0138	PROPN
admet-1513	1255	9	https://doi.org/10.1089/adt.2016.729	https://doi.org/10.1089/adt.2016.729	PROPN
admet-1513	1255	10	https://doi.org/10.1093/toxsci/kfv048	https://doi.org/10.1093/toxsci/kfv048	ADP
admet-1513	1255	11	https://doi.org/10.1016/j.stem.2015.12.005	https://doi.org/10.1016/j.stem.2015.12.005	PROPN
admet-1513	1255	12	https://doi.org/10.1155/2019/4508470	https://doi.org/10.1155/2019/4508470	PROPN
admet-1513	1255	13	https://doi.org/10.1016/j.jhep.2016.07.009	https://doi.org/10.1016/j.jhep.2016.07.009	PROPN
admet-1513	1255	14	admet	admet	PROPN
admet-1513	1255	15	&	&	CCONJ
admet-1513	1255	16	dmpk	dmpk	PROPN
admet-1513	1255	17	11(1	11(1	NUM
admet-1513	1255	18	)	)	PUNCT
admet-1513	1255	19	(	(	PUNCT
admet-1513	1255	20	2023	2023	NUM
admet-1513	1255	21	)	)	PUNCT
admet-1513	1255	22	1	1	NUM
admet-1513	1255	23	-	-	SYM
admet-1513	1255	24	32	32	NUM
admet-1513	1255	25	2d	2d	NOUN
admet-1513	1255	26	and	and	CCONJ
admet-1513	1255	27	3d	3d	NOUN
admet-1513	1255	28	adme	adme	PROPN
admet-1513	1255	29	-	-	PUNCT
admet-1513	1255	30	tox	tox	NOUN
admet-1513	1255	31	cell	cell	NOUN
admet-1513	1255	32	culture	culture	NOUN
admet-1513	1255	33	screening	screen	VERB
admet-1513	1255	34	:	:	PUNCT
admet-1513	1255	35	a	a	DET
admet-1513	1255	36	review	review	NOUN
admet-1513	1255	37	doi	doi	NOUN
admet-1513	1255	38	:	:	PUNCT
admet-1513	1255	39	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	1255	40	27	27	NUM
admet-1513	1256	1	[	[	X
admet-1513	1256	2	144	144	NUM
admet-1513	1256	3	]	]	X
admet-1513	1256	4	d.g	d.g	PROPN
admet-1513	1256	5	.	.	PROPN
admet-1513	1256	6	nguyen	nguyen	PROPN
admet-1513	1256	7	,	,	PUNCT
admet-1513	1256	8	j.	j.	PROPN
admet-1513	1256	9	funk	funk	PROPN
admet-1513	1256	10	,	,	PUNCT
admet-1513	1256	11	j.b	j.b	PROPN
admet-1513	1256	12	.	.	PROPN
admet-1513	1256	13	robbins	robbins	PROPN
admet-1513	1256	14	,	,	PUNCT
admet-1513	1256	15	c.	c.	NOUN
admet-1513	1256	16	crogan	crogan	NOUN
admet-1513	1256	17	-	-	PUNCT
admet-1513	1256	18	grundy	grundy	PROPN
admet-1513	1256	19	,	,	PUNCT
admet-1513	1256	20	s.c	s.c	PROPN
admet-1513	1256	21	.	.	PROPN
admet-1513	1256	22	presnell	presnell	PROPN
admet-1513	1256	23	,	,	PUNCT
admet-1513	1256	24	t.	t.	NOUN
admet-1513	1256	25	singer	singer	NOUN
admet-1513	1256	26	,	,	PUNCT
admet-1513	1256	27	a.b	a.b	PROPN
admet-1513	1256	28	.	.	PROPN
admet-1513	1256	29	roth	roth	PROPN
admet-1513	1256	30	.	.	PROPN
admet-1513	1257	1	bioprinted	bioprinte	VERB
admet-1513	1257	2	3d	3d	NUM
admet-1513	1257	3	primary	primary	ADJ
admet-1513	1257	4	liver	liver	NOUN
admet-1513	1257	5	tissues	tissue	NOUN
admet-1513	1257	6	allow	allow	VERB
admet-1513	1257	7	assessment	assessment	NOUN
admet-1513	1257	8	of	of	ADP
admet-1513	1257	9	organ	organ	NOUN
admet-1513	1257	10	-	-	PUNCT
admet-1513	1257	11	level	level	NOUN
admet-1513	1257	12	response	response	NOUN
admet-1513	1257	13	to	to	ADP
admet-1513	1257	14	clinical	clinical	ADJ
admet-1513	1257	15	drug	drug	NOUN
admet-1513	1257	16	induced	induce	VERB
admet-1513	1257	17	toxicity	toxicity	NOUN
admet-1513	1257	18	in	in	ADP
admet-1513	1257	19	vitro	vitro	X
admet-1513	1257	20	.	.	PUNCT
admet-1513	1258	1	plos	plos	PROPN
admet-1513	1258	2	one	one	NUM
admet-1513	1258	3	11	11	NUM
admet-1513	1258	4	(	(	PUNCT
admet-1513	1258	5	2016	2016	NUM
admet-1513	1258	6	)	)	PUNCT
admet-1513	1258	7	e0158674	e0158674	VERB
admet-1513	1258	8	.	.	PUNCT
admet-1513	1259	1	https://doi.org/10.1371/journal.pone.0158674	https://doi.org/10.1371/journal.pone.0158674	NOUN
admet-1513	1259	2	.	.	PUNCT
admet-1513	1260	1	[	[	X
admet-1513	1260	2	145	145	NUM
admet-1513	1260	3	]	]	X
admet-1513	1260	4	c.h	c.h	PROPN
admet-1513	1260	5	.	.	PROPN
admet-1513	1260	6	beckwitt	beckwitt	PROPN
admet-1513	1260	7	,	,	PUNCT
admet-1513	1260	8	a.m.	a.m.	PROPN
admet-1513	1260	9	clark	clark	PROPN
admet-1513	1260	10	,	,	PUNCT
admet-1513	1260	11	s.	s.	PROPN
admet-1513	1260	12	wheeler	wheeler	PROPN
admet-1513	1260	13	,	,	PUNCT
admet-1513	1260	14	d.l	d.l	PROPN
admet-1513	1260	15	.	.	PROPN
admet-1513	1260	16	taylor	taylor	PROPN
admet-1513	1260	17	,	,	PUNCT
admet-1513	1260	18	d.b	d.b	PROPN
admet-1513	1260	19	.	.	PROPN
admet-1513	1260	20	stolz	stolz	PROPN
admet-1513	1260	21	,	,	PUNCT
admet-1513	1260	22	l.	l.	PROPN
admet-1513	1260	23	griffith	griffith	PROPN
admet-1513	1260	24	,	,	PUNCT
admet-1513	1260	25	a.	a.	NOUN
admet-1513	1260	26	wells	wells	PROPN
admet-1513	1260	27	.	.	PUNCT
admet-1513	1261	1	liver	liver	NOUN
admet-1513	1261	2	'	'	PUNCT
admet-1513	1261	3	organ	organ	NOUN
admet-1513	1261	4	on	on	ADP
admet-1513	1261	5	a	a	DET
admet-1513	1261	6	chip	chip	NOUN
admet-1513	1261	7	'	'	PUNCT
admet-1513	1261	8	.	.	PUNCT
admet-1513	1262	1	exp	exp	NOUN
admet-1513	1262	2	.	.	PUNCT
admet-1513	1262	3	cell	cell	NOUN
admet-1513	1262	4	res	re	NOUN
admet-1513	1262	5	.	.	PUNCT
admet-1513	1263	1	363	363	NUM
admet-1513	1263	2	(	(	PUNCT
admet-1513	1263	3	2018	2018	NUM
admet-1513	1263	4	)	)	PUNCT
admet-1513	1263	5	15	15	NUM
admet-1513	1263	6	-	-	SYM
admet-1513	1263	7	25	25	NUM
admet-1513	1263	8	.	.	PUNCT
admet-1513	1264	1	https://doi.org/10.1016/j.yexcr.2017.12.023	https://doi.org/10.1016/j.yexcr.2017.12.023	NUM
admet-1513	1264	2	.	.	PUNCT
admet-1513	1265	1	[	[	X
admet-1513	1265	2	146	146	NUM
admet-1513	1265	3	]	]	X
admet-1513	1265	4	y.	y.	PROPN
admet-1513	1265	5	li	li	PROPN
admet-1513	1265	6	,	,	PUNCT
admet-1513	1265	7	x.	x.	PROPN
admet-1513	1265	8	yang	yang	PROPN
admet-1513	1265	9	,	,	PUNCT
admet-1513	1265	10	r.	r.	PROPN
admet-1513	1265	11	plummer	plummer	PROPN
admet-1513	1265	12	,	,	PUNCT
admet-1513	1265	13	y.	y.	PROPN
admet-1513	1265	14	hayashi	hayashi	PROPN
admet-1513	1265	15	,	,	PUNCT
admet-1513	1265	16	x.s	x.s	PROPN
admet-1513	1265	17	.	.	PROPN
admet-1513	1265	18	deng	deng	PROPN
admet-1513	1265	19	,	,	PUNCT
admet-1513	1265	20	y.z	y.z	PROPN
admet-1513	1265	21	.	.	PROPN
admet-1513	1265	22	nie	nie	PROPN
admet-1513	1265	23	,	,	PUNCT
admet-1513	1265	24	h.	h.	PROPN
admet-1513	1265	25	taniguchi	taniguchi	PROPN
admet-1513	1265	26	.	.	PUNCT
admet-1513	1266	1	human	human	ADJ
admet-1513	1266	2	pluripotent	pluripotent	ADJ
admet-1513	1266	3	stem	stem	NOUN
admet-1513	1266	4	cellderived	cellderive	VERB
admet-1513	1266	5	hepatocyte	hepatocyte	NOUN
admet-1513	1266	6	-	-	PUNCT
admet-1513	1266	7	like	like	ADJ
admet-1513	1266	8	cells	cell	NOUN
admet-1513	1266	9	and	and	CCONJ
admet-1513	1266	10	organoids	organoid	NOUN
admet-1513	1266	11	for	for	ADP
admet-1513	1266	12	liver	liver	NOUN
admet-1513	1266	13	disease	disease	NOUN
admet-1513	1266	14	and	and	CCONJ
admet-1513	1266	15	therapy	therapy	NOUN
admet-1513	1266	16	.	.	PUNCT
admet-1513	1267	1	int	int	NOUN
admet-1513	1267	2	.	.	PUNCT
admet-1513	1268	1	j.	j.	PROPN
admet-1513	1268	2	mol	mol	PROPN
admet-1513	1268	3	.	.	PUNCT
admet-1513	1269	1	sci	sci	PROPN
admet-1513	1269	2	.	.	PROPN
admet-1513	1269	3	22	22	NUM
admet-1513	1269	4	(	(	PUNCT
admet-1513	1269	5	2021	2021	NUM
admet-1513	1269	6	)	)	PUNCT
admet-1513	1269	7	10471	10471	NUM
admet-1513	1269	8	.	.	PUNCT
admet-1513	1270	1	https://doi.org/10.3390/ijms221910471	https://doi.org/10.3390/ijms221910471	PROPN
admet-1513	1270	2	.	.	PUNCT
admet-1513	1271	1	[	[	X
admet-1513	1271	2	147	147	NUM
admet-1513	1271	3	]	]	X
admet-1513	1271	4	s.j	s.j	PROPN
admet-1513	1271	5	.	.	PROPN
admet-1513	1271	6	mun	mun	PROPN
admet-1513	1271	7	,	,	PUNCT
admet-1513	1271	8	j.s	j.s	PROPN
admet-1513	1271	9	.	.	PROPN
admet-1513	1271	10	ryu	ryu	PROPN
admet-1513	1271	11	,	,	PUNCT
admet-1513	1271	12	m.o	m.o	PROPN
admet-1513	1271	13	.	.	PROPN
admet-1513	1271	14	lee	lee	PROPN
admet-1513	1271	15	,	,	PUNCT
admet-1513	1271	16	y.s	y.s	PROPN
admet-1513	1271	17	.	.	PROPN
admet-1513	1271	18	son	son	PROPN
admet-1513	1271	19	,	,	PUNCT
admet-1513	1271	20	s.j	s.j	PROPN
admet-1513	1271	21	.	.	PROPN
admet-1513	1272	1	oh	oh	INTJ
admet-1513	1272	2	,	,	PUNCT
admet-1513	1272	3	h.s	h.s	PROPN
admet-1513	1272	4	.	.	PROPN
admet-1513	1272	5	cho	cho	PROPN
admet-1513	1272	6	,	,	PUNCT
admet-1513	1272	7	m.y	m.y	PROPN
admet-1513	1272	8	.	.	PROPN
admet-1513	1272	9	son	son	PROPN
admet-1513	1272	10	,	,	PUNCT
admet-1513	1272	11	d.s	d.s	PROPN
admet-1513	1272	12	.	.	PROPN
admet-1513	1272	13	kim	kim	PROPN
admet-1513	1272	14	,	,	PUNCT
admet-1513	1272	15	s.j	s.j	PROPN
admet-1513	1272	16	.	.	PROPN
admet-1513	1272	17	kim	kim	PROPN
admet-1513	1272	18	,	,	PUNCT
admet-1513	1272	19	h.j	h.j	PROPN
admet-1513	1272	20	.	.	PROPN
admet-1513	1272	21	yoo	yoo	PROPN
admet-1513	1272	22	,	,	PUNCT
admet-1513	1272	23	h.j	h.j	PROPN
admet-1513	1272	24	.	.	PROPN
admet-1513	1272	25	lee	lee	PROPN
admet-1513	1272	26	,	,	PUNCT
admet-1513	1272	27	j.	j.	PROPN
admet-1513	1272	28	kim	kim	PROPN
admet-1513	1272	29	,	,	PUNCT
admet-1513	1272	30	c.r	c.r	PROPN
admet-1513	1272	31	.	.	PROPN
admet-1513	1272	32	jung	jung	PROPN
admet-1513	1272	33	,	,	PUNCT
admet-1513	1272	34	k.s	k.s	PROPN
admet-1513	1272	35	.	.	PROPN
admet-1513	1272	36	chung	chung	PROPN
admet-1513	1272	37	,	,	PUNCT
admet-1513	1272	38	m.j	m.j	PROPN
admet-1513	1272	39	.	.	PROPN
admet-1513	1272	40	son	son	PROPN
admet-1513	1272	41	.	.	PUNCT
admet-1513	1273	1	generation	generation	NOUN
admet-1513	1273	2	of	of	ADP
admet-1513	1273	3	expandable	expandable	ADJ
admet-1513	1273	4	human	human	ADJ
admet-1513	1273	5	pluripotent	pluripotent	NOUN
admet-1513	1273	6	stem	stem	NOUN
admet-1513	1273	7	cell	cell	NOUN
admet-1513	1273	8	-	-	PUNCT
admet-1513	1273	9	derived	derive	VERB
admet-1513	1273	10	hepatocyte	hepatocyte	NOUN
admet-1513	1273	11	-	-	PUNCT
admet-1513	1273	12	like	like	ADJ
admet-1513	1273	13	liver	liver	NOUN
admet-1513	1273	14	organoids	organoid	NOUN
admet-1513	1273	15	.	.	PUNCT
admet-1513	1274	1	j.	j.	PROPN
admet-1513	1274	2	hepatol	hepatol	PROPN
admet-1513	1274	3	.	.	PUNCT
admet-1513	1275	1	71	71	NUM
admet-1513	1275	2	(	(	PUNCT
admet-1513	1275	3	2019	2019	NUM
admet-1513	1275	4	)	)	PUNCT
admet-1513	1275	5	970	970	NUM
admet-1513	1275	6	-	-	SYM
admet-1513	1275	7	985	985	NUM
admet-1513	1275	8	.	.	PUNCT
admet-1513	1276	1	https://doi.org/10.1016/j.jhep.2019.06.030	https://doi.org/10.1016/j.jhep.2019.06.030	NOUN
admet-1513	1276	2	.	.	PUNCT
admet-1513	1277	1	[	[	X
admet-1513	1277	2	148	148	NUM
admet-1513	1277	3	]	]	X
admet-1513	1277	4	d.j	d.j	PROPN
admet-1513	1277	5	.	.	PROPN
admet-1513	1277	6	hughes	hughes	PROPN
admet-1513	1277	7	,	,	PUNCT
admet-1513	1277	8	t.	t.	PROPN
admet-1513	1277	9	kostrzewski	kostrzewski	PROPN
admet-1513	1277	10	,	,	PUNCT
admet-1513	1277	11	e.l	e.l	PROPN
admet-1513	1277	12	.	.	PROPN
admet-1513	1277	13	sceats	sceats	PROPN
admet-1513	1277	14	.	.	PUNCT
admet-1513	1278	1	opportunities	opportunity	NOUN
admet-1513	1278	2	and	and	CCONJ
admet-1513	1278	3	challenges	challenge	NOUN
admet-1513	1278	4	in	in	ADP
admet-1513	1278	5	the	the	DET
admet-1513	1278	6	wider	wide	ADJ
admet-1513	1278	7	adoption	adoption	NOUN
admet-1513	1278	8	of	of	ADP
admet-1513	1278	9	liver	liver	NOUN
admet-1513	1278	10	and	and	CCONJ
admet-1513	1278	11	interconnected	interconnected	ADJ
admet-1513	1278	12	microphysiological	microphysiological	ADJ
admet-1513	1278	13	systems	system	NOUN
admet-1513	1278	14	.	.	PUNCT
admet-1513	1279	1	exp	exp	NOUN
admet-1513	1279	2	.	.	PUNCT
admet-1513	1280	1	biol	biol	PROPN
admet-1513	1280	2	.	.	PUNCT
admet-1513	1281	1	med	med	PROPN
admet-1513	1281	2	.	.	PUNCT
admet-1513	1282	1	(	(	PUNCT
admet-1513	1282	2	maywood	maywood	PROPN
admet-1513	1282	3	)	)	PUNCT
admet-1513	1282	4	242	242	NUM
admet-1513	1282	5	(	(	PUNCT
admet-1513	1282	6	2017	2017	NUM
admet-1513	1282	7	)	)	PUNCT
admet-1513	1282	8	1593	1593	NUM
admet-1513	1282	9	-	-	SYM
admet-1513	1282	10	1604	1604	NUM
admet-1513	1282	11	.	.	PUNCT
admet-1513	1283	1	https://doi.org/10.1016/j.jhep.2019.06.030	https://doi.org/10.1016/j.jhep.2019.06.030	NOUN
admet-1513	1283	2	.	.	PUNCT
admet-1513	1284	1	[	[	X
admet-1513	1284	2	149	149	NUM
admet-1513	1284	3	]	]	PUNCT
admet-1513	1284	4	t.	t.	NOUN
admet-1513	1284	5	takebe	takebe	NOUN
admet-1513	1284	6	,	,	PUNCT
admet-1513	1284	7	k.	k.	PROPN
admet-1513	1284	8	sekine	sekine	PROPN
admet-1513	1284	9	,	,	PUNCT
admet-1513	1284	10	m.	m.	NOUN
admet-1513	1284	11	enomura	enomura	PROPN
admet-1513	1284	12	,	,	PUNCT
admet-1513	1284	13	h.	h.	PROPN
admet-1513	1284	14	koike	koike	PROPN
admet-1513	1284	15	,	,	PUNCT
admet-1513	1284	16	m.	m.	NOUN
admet-1513	1284	17	kimura	kimura	PROPN
admet-1513	1284	18	,	,	PUNCT
admet-1513	1284	19	t.	t.	PROPN
admet-1513	1284	20	ogaeri	ogaeri	PROPN
admet-1513	1284	21	,	,	PUNCT
admet-1513	1284	22	r.r	r.r	PROPN
admet-1513	1284	23	.	.	PROPN
admet-1513	1284	24	zhang	zhang	PROPN
admet-1513	1284	25	,	,	PUNCT
admet-1513	1284	26	y.	y.	PROPN
admet-1513	1284	27	ueno	ueno	PROPN
admet-1513	1284	28	,	,	PUNCT
admet-1513	1284	29	y.w	y.w	PROPN
admet-1513	1284	30	.	.	PROPN
admet-1513	1284	31	zheng	zheng	PROPN
admet-1513	1284	32	,	,	PUNCT
admet-1513	1284	33	n.	n.	PROPN
admet-1513	1284	34	koike	koike	PROPN
admet-1513	1284	35	,	,	PUNCT
admet-1513	1284	36	s.	s.	PROPN
admet-1513	1284	37	aoyama	aoyama	PROPN
admet-1513	1284	38	,	,	PUNCT
admet-1513	1284	39	y.	y.	PROPN
admet-1513	1284	40	adachi	adachi	PROPN
admet-1513	1284	41	,	,	PUNCT
admet-1513	1284	42	h.	h.	PROPN
admet-1513	1284	43	taniguchi	taniguchi	PROPN
admet-1513	1284	44	.	.	PUNCT
admet-1513	1284	45	vascularized	vascularized	ADJ
admet-1513	1284	46	and	and	CCONJ
admet-1513	1284	47	functional	functional	ADJ
admet-1513	1284	48	human	human	ADJ
admet-1513	1284	49	liver	liver	NOUN
admet-1513	1284	50	from	from	ADP
admet-1513	1284	51	an	an	DET
admet-1513	1284	52	ipscderived	ipscderived	ADJ
admet-1513	1284	53	organ	organ	NOUN
admet-1513	1284	54	bud	bud	NOUN
admet-1513	1284	55	transplant	transplant	NOUN
admet-1513	1284	56	.	.	PUNCT
admet-1513	1285	1	nature	nature	NOUN
admet-1513	1285	2	499	499	NUM
admet-1513	1285	3	(	(	PUNCT
admet-1513	1285	4	2013	2013	NUM
admet-1513	1285	5	)	)	PUNCT
admet-1513	1285	6	481	481	NUM
admet-1513	1285	7	-	-	SYM
admet-1513	1285	8	484	484	NUM
admet-1513	1285	9	.	.	PUNCT
admet-1513	1286	1	https://doi.org/10.1038/nature12271	https://doi.org/10.1038/nature12271	NOUN
admet-1513	1286	2	.	.	PUNCT
admet-1513	1287	1	[	[	X
admet-1513	1287	2	150	150	NUM
admet-1513	1287	3	]	]	PUNCT
admet-1513	1287	4	t.	t.	NOUN
admet-1513	1287	5	takebe	takebe	NOUN
admet-1513	1287	6	,	,	PUNCT
admet-1513	1287	7	k.	k.	PROPN
admet-1513	1287	8	sekine	sekine	PROPN
admet-1513	1287	9	,	,	PUNCT
admet-1513	1287	10	m.	m.	NOUN
admet-1513	1287	11	kimura	kimura	PROPN
admet-1513	1287	12	,	,	PUNCT
admet-1513	1287	13	e.	e.	PROPN
admet-1513	1287	14	yoshizawa	yoshizawa	PROPN
admet-1513	1287	15	,	,	PUNCT
admet-1513	1287	16	s.	s.	PROPN
admet-1513	1287	17	ayano	ayano	PROPN
admet-1513	1287	18	,	,	PUNCT
admet-1513	1287	19	m.	m.	NOUN
admet-1513	1287	20	koido	koido	PROPN
admet-1513	1287	21	,	,	PUNCT
admet-1513	1287	22	s.	s.	PROPN
admet-1513	1287	23	funayama	funayama	PROPN
admet-1513	1287	24	,	,	PUNCT
admet-1513	1287	25	n.	n.	PROPN
admet-1513	1287	26	nakanishi	nakanishi	PROPN
admet-1513	1287	27	,	,	PUNCT
admet-1513	1287	28	t.	t.	PROPN
admet-1513	1287	29	hisai	hisai	PROPN
admet-1513	1287	30	,	,	PUNCT
admet-1513	1287	31	t.	t.	PROPN
admet-1513	1287	32	kobayashi	kobayashi	PROPN
admet-1513	1287	33	,	,	PUNCT
admet-1513	1287	34	t.	t.	PROPN
admet-1513	1287	35	kasai	kasai	PROPN
admet-1513	1287	36	,	,	PUNCT
admet-1513	1287	37	r.	r.	PROPN
admet-1513	1287	38	kitada	kitada	PROPN
admet-1513	1287	39	,	,	PUNCT
admet-1513	1287	40	a.	a.	NOUN
admet-1513	1287	41	mori	mori	PROPN
admet-1513	1287	42	,	,	PUNCT
admet-1513	1287	43	h.	h.	PROPN
admet-1513	1287	44	ayabe	ayabe	PROPN
admet-1513	1287	45	,	,	PUNCT
admet-1513	1287	46	y.	y.	PROPN
admet-1513	1287	47	ejiri	ejiri	PROPN
admet-1513	1287	48	,	,	PUNCT
admet-1513	1287	49	n.	n.	PROPN
admet-1513	1287	50	amimoto	amimoto	PROPN
admet-1513	1287	51	,	,	PUNCT
admet-1513	1287	52	y.	y.	PROPN
admet-1513	1287	53	yamazaki	yamazaki	PROPN
admet-1513	1287	54	,	,	PUNCT
admet-1513	1287	55	s.	s.	PROPN
admet-1513	1287	56	ogawa	ogawa	PROPN
admet-1513	1287	57	,	,	PUNCT
admet-1513	1287	58	m.	m.	NOUN
admet-1513	1287	59	ishikawa	ishikawa	PROPN
admet-1513	1287	60	,	,	PUNCT
admet-1513	1287	61	y.	y.	PROPN
admet-1513	1287	62	kiyota	kiyota	PROPN
admet-1513	1287	63	,	,	PUNCT
admet-1513	1287	64	y.	y.	PROPN
admet-1513	1287	65	sato	sato	PROPN
admet-1513	1287	66	,	,	PUNCT
admet-1513	1287	67	k.	k.	PROPN
admet-1513	1287	68	nozawa	nozawa	PROPN
admet-1513	1287	69	,	,	PUNCT
admet-1513	1287	70	s.	s.	PROPN
admet-1513	1287	71	okamoto	okamoto	PROPN
admet-1513	1287	72	,	,	PUNCT
admet-1513	1287	73	y.	y.	PROPN
admet-1513	1287	74	ueno	ueno	PROPN
admet-1513	1287	75	,	,	PUNCT
admet-1513	1287	76	h.	h.	PROPN
admet-1513	1287	77	taniguchi	taniguchi	PROPN
admet-1513	1287	78	.	.	PROPN
admet-1513	1288	1	massive	massive	ADJ
admet-1513	1288	2	and	and	CCONJ
admet-1513	1288	3	reproducible	reproducible	ADJ
admet-1513	1288	4	production	production	NOUN
admet-1513	1288	5	of	of	ADP
admet-1513	1288	6	liver	liver	NOUN
admet-1513	1288	7	buds	bud	NOUN
admet-1513	1288	8	entirely	entirely	ADV
admet-1513	1288	9	from	from	ADP
admet-1513	1288	10	human	human	ADJ
admet-1513	1288	11	pluripotent	pluripotent	NOUN
admet-1513	1288	12	stem	stem	NOUN
admet-1513	1288	13	cells	cell	NOUN
admet-1513	1288	14	.	.	PUNCT
admet-1513	1289	1	cell	cell	NOUN
admet-1513	1289	2	rep	rep	PROPN
admet-1513	1289	3	.	.	PROPN
admet-1513	1289	4	21	21	NUM
admet-1513	1289	5	(	(	PUNCT
admet-1513	1289	6	2017	2017	NUM
admet-1513	1289	7	)	)	PUNCT
admet-1513	1289	8	2661	2661	NUM
admet-1513	1289	9	-	-	SYM
admet-1513	1289	10	2670	2670	NUM
admet-1513	1289	11	.	.	PUNCT
admet-1513	1290	1	https://doi.org/10.1016/j.celrep.2017.11.005	https://doi.org/10.1016/j.celrep.2017.11.005	PROPN
admet-1513	1290	2	.	.	PUNCT
admet-1513	1291	1	[	[	X
admet-1513	1291	2	151	151	NUM
admet-1513	1291	3	]	]	X
admet-1513	1291	4	g.	g.	PROPN
admet-1513	1291	5	pettinato	pettinato	PROPN
admet-1513	1291	6	,	,	PUNCT
admet-1513	1291	7	s.	s.	PROPN
admet-1513	1291	8	lehoux	lehoux	PROPN
admet-1513	1291	9	,	,	PUNCT
admet-1513	1291	10	r.	r.	PROPN
admet-1513	1291	11	ramanathan	ramanathan	PROPN
admet-1513	1291	12	,	,	PUNCT
admet-1513	1291	13	m.m	m.m	PROPN
admet-1513	1291	14	.	.	PROPN
admet-1513	1291	15	salem	salem	PROPN
admet-1513	1291	16	,	,	PUNCT
admet-1513	1291	17	l.x	l.x	PROPN
admet-1513	1291	18	.	.	PUNCT
admet-1513	1292	1	he	he	PRON
admet-1513	1292	2	,	,	PUNCT
admet-1513	1292	3	o.	o.	PROPN
admet-1513	1292	4	muse	muse	PROPN
admet-1513	1292	5	,	,	PUNCT
admet-1513	1292	6	r.	r.	PROPN
admet-1513	1292	7	flaumenhaft	flaumenhaft	PROPN
admet-1513	1292	8	,	,	PUNCT
admet-1513	1292	9	m.t	m.t	PROPN
admet-1513	1292	10	.	.	PROPN
admet-1513	1292	11	thompson	thompson	PROPN
admet-1513	1292	12	,	,	PUNCT
admet-1513	1292	13	e.a	e.a	PROPN
admet-1513	1292	14	.	.	PROPN
admet-1513	1292	15	rouse	rouse	PROPN
admet-1513	1292	16	,	,	PUNCT
admet-1513	1292	17	r.d	r.d	PROPN
admet-1513	1292	18	.	.	PROPN
admet-1513	1292	19	cummings	cummings	PROPN
admet-1513	1292	20	,	,	PUNCT
admet-1513	1292	21	x.	x.	PROPN
admet-1513	1292	22	wen	wen	PROPN
admet-1513	1292	23	,	,	PUNCT
admet-1513	1292	24	r.a	r.a	PROPN
admet-1513	1292	25	.	.	PROPN
admet-1513	1292	26	fisher	fisher	PROPN
admet-1513	1292	27	.	.	PUNCT
admet-1513	1293	1	generation	generation	NOUN
admet-1513	1293	2	of	of	ADP
admet-1513	1293	3	fully	fully	ADV
admet-1513	1293	4	functional	functional	ADJ
admet-1513	1293	5	hepatocyte	hepatocyte	NOUN
admet-1513	1293	6	-	-	PUNCT
admet-1513	1293	7	like	like	ADJ
admet-1513	1293	8	organoids	organoid	NOUN
admet-1513	1293	9	from	from	ADP
admet-1513	1293	10	human	human	ADJ
admet-1513	1293	11	induced	induce	VERB
admet-1513	1293	12	pluripotent	pluripotent	NOUN
admet-1513	1293	13	stem	stem	NOUN
admet-1513	1293	14	cells	cell	NOUN
admet-1513	1293	15	mixed	mix	VERB
admet-1513	1293	16	with	with	ADP
admet-1513	1293	17	endothelial	endothelial	ADJ
admet-1513	1293	18	cells	cell	NOUN
admet-1513	1293	19	.	.	PUNCT
admet-1513	1294	1	sci	sci	PROPN
admet-1513	1294	2	.	.	PROPN
admet-1513	1294	3	rep	rep	PROPN
admet-1513	1294	4	.	.	PROPN
admet-1513	1294	5	9	9	NUM
admet-1513	1294	6	(	(	PUNCT
admet-1513	1294	7	2019	2019	NUM
admet-1513	1294	8	)	)	PUNCT
admet-1513	1294	9	8920	8920	NUM
admet-1513	1294	10	.	.	PUNCT
admet-1513	1295	1	https://doi.org/10.1038/s41598-019-45514-3	https://doi.org/10.1038/s41598-019-45514-3	NOUN
admet-1513	1295	2	.	.	PUNCT
admet-1513	1296	1	[	[	X
admet-1513	1296	2	152	152	NUM
admet-1513	1296	3	]	]	X
admet-1513	1296	4	y.	y.	PROPN
admet-1513	1296	5	guan	guan	PROPN
admet-1513	1296	6	,	,	PUNCT
admet-1513	1296	7	d.	d.	PROPN
admet-1513	1296	8	xu	xu	PROPN
admet-1513	1296	9	,	,	PUNCT
admet-1513	1296	10	p.m.	p.m.	NOUN
admet-1513	1296	11	garfin	garfin	PROPN
admet-1513	1296	12	,	,	PUNCT
admet-1513	1296	13	u.	u.	PROPN
admet-1513	1296	14	ehmer	ehmer	PROPN
admet-1513	1296	15	,	,	PUNCT
admet-1513	1296	16	m.	m.	PROPN
admet-1513	1296	17	hurwitz	hurwitz	PROPN
admet-1513	1296	18	,	,	PUNCT
admet-1513	1296	19	g.	g.	PROPN
admet-1513	1296	20	enns	enns	PROPN
admet-1513	1296	21	,	,	PUNCT
admet-1513	1296	22	s.	s.	PROPN
admet-1513	1296	23	michie	michie	PROPN
admet-1513	1296	24	,	,	PUNCT
admet-1513	1296	25	m.	m.	PROPN
admet-1513	1296	26	wu	wu	PROPN
admet-1513	1296	27	,	,	PUNCT
admet-1513	1296	28	m.	m.	NOUN
admet-1513	1296	29	zheng	zheng	PROPN
admet-1513	1296	30	,	,	PUNCT
admet-1513	1296	31	t.	t.	PROPN
admet-1513	1296	32	nishimura	nishimura	PROPN
admet-1513	1296	33	,	,	PUNCT
admet-1513	1296	34	j.	j.	PROPN
admet-1513	1296	35	sage	sage	PROPN
admet-1513	1296	36	,	,	PUNCT
admet-1513	1296	37	g.	g.	PROPN
admet-1513	1296	38	peltz	peltz	PROPN
admet-1513	1296	39	.	.	PUNCT
admet-1513	1297	1	human	human	ADJ
admet-1513	1297	2	hepatic	hepatic	ADJ
admet-1513	1297	3	organoids	organoid	NOUN
admet-1513	1297	4	for	for	ADP
admet-1513	1297	5	the	the	DET
admet-1513	1297	6	analysis	analysis	NOUN
admet-1513	1297	7	of	of	ADP
admet-1513	1297	8	human	human	ADJ
admet-1513	1297	9	genetic	genetic	ADJ
admet-1513	1297	10	diseases	disease	NOUN
admet-1513	1297	11	.	.	PUNCT
admet-1513	1298	1	jci	jci	PROPN
admet-1513	1298	2	insight	insight	PROPN
admet-1513	1298	3	2	2	NUM
admet-1513	1298	4	(	(	PUNCT
admet-1513	1298	5	2017	2017	NUM
admet-1513	1298	6	)	)	PUNCT
admet-1513	1298	7	94954	94954	NUM
admet-1513	1298	8	.	.	PUNCT
admet-1513	1299	1	https://doi.org/10.1172/jci.insight.94954	https://doi.org/10.1172/jci.insight.94954	PROPN
admet-1513	1299	2	.	.	PUNCT
admet-1513	1300	1	[	[	X
admet-1513	1300	2	153	153	NUM
admet-1513	1300	3	]	]	PUNCT
admet-1513	1300	4	f.	f.	PROPN
admet-1513	1300	5	wu	wu	PROPN
admet-1513	1300	6	,	,	PUNCT
admet-1513	1300	7	d.	d.	PROPN
admet-1513	1300	8	wu	wu	PROPN
admet-1513	1300	9	,	,	PUNCT
admet-1513	1300	10	y.	y.	PROPN
admet-1513	1300	11	ren	ren	PROPN
admet-1513	1300	12	,	,	PUNCT
admet-1513	1300	13	y.	y.	PROPN
admet-1513	1300	14	huang	huang	PROPN
admet-1513	1300	15	,	,	PUNCT
admet-1513	1300	16	b.	b.	PROPN
admet-1513	1300	17	feng	feng	PROPN
admet-1513	1300	18	,	,	PUNCT
admet-1513	1300	19	n.	n.	PROPN
admet-1513	1300	20	zhao	zhao	PROPN
admet-1513	1300	21	,	,	PUNCT
admet-1513	1300	22	t.	t.	PROPN
admet-1513	1300	23	zhang	zhang	PROPN
admet-1513	1300	24	,	,	PUNCT
admet-1513	1300	25	x.	x.	PROPN
admet-1513	1300	26	chen	chen	PROPN
admet-1513	1300	27	,	,	PUNCT
admet-1513	1300	28	s.	s.	PROPN
admet-1513	1300	29	chen	chen	PROPN
admet-1513	1300	30	,	,	PUNCT
admet-1513	1300	31	a.	a.	PROPN
admet-1513	1300	32	xu	xu	PROPN
admet-1513	1300	33	.	.	PUNCT
admet-1513	1301	1	generation	generation	NOUN
admet-1513	1301	2	of	of	ADP
admet-1513	1301	3	hepatobiliary	hepatobiliary	ADJ
admet-1513	1301	4	organoids	organoid	NOUN
admet-1513	1301	5	from	from	ADP
admet-1513	1301	6	human	human	ADJ
admet-1513	1301	7	induced	induce	VERB
admet-1513	1301	8	pluripotent	pluripotent	ADJ
admet-1513	1301	9	stem	stem	NOUN
admet-1513	1301	10	cells	cell	NOUN
admet-1513	1301	11	.	.	PUNCT
admet-1513	1302	1	j.	j.	PROPN
admet-1513	1302	2	hepatol	hepatol	PROPN
admet-1513	1302	3	.	.	PUNCT
admet-1513	1303	1	70	70	NUM
admet-1513	1303	2	(	(	PUNCT
admet-1513	1303	3	2019	2019	NUM
admet-1513	1303	4	)	)	PUNCT
admet-1513	1303	5	11451158	11451158	NUM
admet-1513	1303	6	.	.	PUNCT
admet-1513	1304	1	https://doi.org/10.1016/j.jhep.2018.12.028	https://doi.org/10.1016/j.jhep.2018.12.028	PROPN
admet-1513	1304	2	.	.	PUNCT
admet-1513	1305	1	[	[	X
admet-1513	1305	2	154	154	NUM
admet-1513	1305	3	]	]	PUNCT
admet-1513	1305	4	r.	r.	PROPN
admet-1513	1305	5	ouchi	ouchi	PROPN
admet-1513	1305	6	,	,	PUNCT
admet-1513	1305	7	s.	s.	PROPN
admet-1513	1305	8	togo	togo	PROPN
admet-1513	1305	9	,	,	PUNCT
admet-1513	1305	10	m.	m.	NOUN
admet-1513	1305	11	kimura	kimura	PROPN
admet-1513	1305	12	,	,	PUNCT
admet-1513	1305	13	t.	t.	PROPN
admet-1513	1305	14	shinozawa	shinozawa	PROPN
admet-1513	1305	15	,	,	PUNCT
admet-1513	1305	16	m.	m.	NOUN
admet-1513	1305	17	koido	koido	PROPN
admet-1513	1305	18	,	,	PUNCT
admet-1513	1305	19	h.	h.	PROPN
admet-1513	1305	20	koike	koike	PROPN
admet-1513	1305	21	,	,	PUNCT
admet-1513	1305	22	w.	w.	PROPN
admet-1513	1305	23	thompson	thompson	PROPN
admet-1513	1305	24	,	,	PUNCT
admet-1513	1305	25	r.a	r.a	PROPN
admet-1513	1305	26	.	.	PROPN
admet-1513	1305	27	karns	karns	PROPN
admet-1513	1305	28	,	,	PUNCT
admet-1513	1305	29	c.n	c.n	PROPN
admet-1513	1305	30	.	.	PROPN
admet-1513	1305	31	mayhew	mayhew	PROPN
admet-1513	1305	32	,	,	PUNCT
admet-1513	1305	33	p.s	p.s	PROPN
admet-1513	1305	34	.	.	PROPN
admet-1513	1305	35	mcgrath	mcgrath	PROPN
admet-1513	1305	36	,	,	PUNCT
admet-1513	1305	37	h.a	h.a	PROPN
admet-1513	1305	38	.	.	PROPN
admet-1513	1305	39	mccauley	mccauley	PROPN
admet-1513	1305	40	,	,	PUNCT
admet-1513	1305	41	r.r	r.r	PROPN
admet-1513	1305	42	.	.	PROPN
admet-1513	1305	43	zhang	zhang	PROPN
admet-1513	1305	44	,	,	PUNCT
admet-1513	1305	45	k.	k.	PROPN
admet-1513	1305	46	lewis	lewis	PROPN
admet-1513	1305	47	,	,	PUNCT
admet-1513	1305	48	s.	s.	PROPN
admet-1513	1305	49	hakozaki	hakozaki	PROPN
admet-1513	1305	50	,	,	PUNCT
admet-1513	1305	51	a.	a.	PROPN
admet-1513	1305	52	ferguson	ferguson	PROPN
admet-1513	1305	53	,	,	PUNCT
admet-1513	1305	54	n.	n.	PROPN
admet-1513	1305	55	saiki	saiki	PROPN
admet-1513	1305	56	,	,	PUNCT
admet-1513	1305	57	y.	y.	PROPN
admet-1513	1305	58	yoneyama	yoneyama	PROPN
admet-1513	1305	59	,	,	PUNCT
admet-1513	1305	60	i.	i.	PROPN
admet-1513	1305	61	takeuchi	takeuchi	PROPN
admet-1513	1305	62	,	,	PUNCT
admet-1513	1305	63	y.	y.	PROPN
admet-1513	1305	64	mabuchi	mabuchi	PROPN
admet-1513	1305	65	,	,	PUNCT
admet-1513	1305	66	c.	c.	PROPN
admet-1513	1305	67	akazawa	akazawa	PROPN
admet-1513	1305	68	,	,	PUNCT
admet-1513	1305	69	h.y	h.y	PROPN
admet-1513	1305	70	.	.	PROPN
admet-1513	1305	71	yoshikawa	yoshikawa	PROPN
admet-1513	1305	72	,	,	PUNCT
admet-1513	1305	73	j.m	j.m	PROPN
admet-1513	1305	74	.	.	PROPN
admet-1513	1305	75	wells	wells	PROPN
admet-1513	1305	76	,	,	PUNCT
admet-1513	1305	77	t.	t.	NOUN
admet-1513	1305	78	takebe	takebe	NOUN
admet-1513	1305	79	.	.	PUNCT
admet-1513	1306	1	modeling	model	VERB
admet-1513	1306	2	steatohepatitis	steatohepatitis	PROPN
admet-1513	1306	3	in	in	ADP
admet-1513	1306	4	humans	human	NOUN
admet-1513	1306	5	with	with	ADP
admet-1513	1306	6	pluripotent	pluripotent	ADJ
admet-1513	1306	7	stem	stem	NOUN
admet-1513	1306	8	cell	cell	NOUN
admet-1513	1306	9	-	-	PUNCT
admet-1513	1306	10	derived	derive	VERB
admet-1513	1306	11	organoids	organoid	NOUN
admet-1513	1306	12	.	.	PUNCT
admet-1513	1307	1	cell	cell	NOUN
admet-1513	1307	2	metab	metab	NOUN
admet-1513	1307	3	.	.	PUNCT
admet-1513	1308	1	30	30	NUM
admet-1513	1308	2	(	(	PUNCT
admet-1513	1308	3	2019	2019	NUM
admet-1513	1308	4	)	)	PUNCT
admet-1513	1309	1	374384.e6	374384.e6	NUM
admet-1513	1309	2	.	.	PUNCT
admet-1513	1309	3	https://doi.org/10.1016/j.cmet.2019.05.007	https://doi.org/10.1016/j.cmet.2019.05.007	PROPN
admet-1513	1309	4	.	.	PUNCT
admet-1513	1310	1	[	[	X
admet-1513	1310	2	155	155	NUM
admet-1513	1310	3	]	]	X
admet-1513	1310	4	n.	n.	PROPN
admet-1513	1310	5	tsamandouras	tsamandouras	PROPN
admet-1513	1310	6	,	,	PUNCT
admet-1513	1310	7	w.l.k	w.l.k	PROPN
admet-1513	1310	8	.	.	PUNCT
admet-1513	1311	1	chen	chen	PROPN
admet-1513	1311	2	,	,	PUNCT
admet-1513	1311	3	c.d	c.d	PROPN
admet-1513	1311	4	.	.	PROPN
admet-1513	1311	5	edington	edington	PROPN
admet-1513	1311	6	,	,	PUNCT
admet-1513	1311	7	c.l	c.l	PROPN
admet-1513	1311	8	.	.	PROPN
admet-1513	1311	9	stokes	stokes	PROPN
admet-1513	1311	10	,	,	PUNCT
admet-1513	1311	11	l.g	l.g	PROPN
admet-1513	1311	12	.	.	PROPN
admet-1513	1311	13	griffith	griffith	PROPN
admet-1513	1311	14	,	,	PUNCT
admet-1513	1311	15	m.	m.	NOUN
admet-1513	1311	16	cirit	cirit	PROPN
admet-1513	1311	17	.	.	PUNCT
admet-1513	1312	1	integrated	integrate	VERB
admet-1513	1312	2	gut	gut	NOUN
admet-1513	1312	3	and	and	CCONJ
admet-1513	1312	4	liver	liver	NOUN
admet-1513	1312	5	microphysiological	microphysiological	ADJ
admet-1513	1312	6	systems	system	NOUN
admet-1513	1312	7	for	for	ADP
admet-1513	1312	8	quantitative	quantitative	ADJ
admet-1513	1312	9	in	in	ADP
admet-1513	1312	10	vitro	vitro	X
admet-1513	1312	11	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	1312	12	studies	study	NOUN
admet-1513	1312	13	.	.	PUNCT
admet-1513	1313	1	aaps	aaps	PROPN
admet-1513	1313	2	j.	j.	PROPN
admet-1513	1313	3	19	19	NUM
admet-1513	1313	4	(	(	PUNCT
admet-1513	1313	5	2017	2017	NUM
admet-1513	1313	6	)	)	PUNCT
admet-1513	1313	7	1499	1499	NUM
admet-1513	1313	8	-	-	SYM
admet-1513	1313	9	1512	1512	NUM
admet-1513	1313	10	.	.	PUNCT
admet-1513	1314	1	https://doi.org/10.1208/s12248-017-0122-4	https://doi.org/10.1208/s12248-017-0122-4	NUM
admet-1513	1314	2	.	.	PUNCT
admet-1513	1315	1	[	[	X
admet-1513	1315	2	156	156	NUM
admet-1513	1315	3	]	]	PUNCT
admet-1513	1315	4	a.	a.	NOUN
admet-1513	1315	5	herland	herland	PROPN
admet-1513	1315	6	,	,	PUNCT
admet-1513	1315	7	b.m	b.m	PROPN
admet-1513	1315	8	.	.	PROPN
admet-1513	1315	9	maoz	maoz	PROPN
admet-1513	1315	10	,	,	PUNCT
admet-1513	1315	11	d.	d.	PROPN
admet-1513	1315	12	das	das	PROPN
admet-1513	1315	13	,	,	PUNCT
admet-1513	1315	14	m.r	m.r	PROPN
admet-1513	1315	15	.	.	PROPN
admet-1513	1315	16	somayaji	somayaji	PROPN
admet-1513	1315	17	,	,	PUNCT
admet-1513	1315	18	r.	r.	PROPN
admet-1513	1315	19	prantil	prantil	PROPN
admet-1513	1315	20	-	-	PUNCT
admet-1513	1315	21	baun	baun	NOUN
admet-1513	1315	22	,	,	PUNCT
admet-1513	1315	23	r.	r.	PROPN
admet-1513	1315	24	novak	novak	PROPN
admet-1513	1315	25	,	,	PUNCT
admet-1513	1315	26	m.	m.	NOUN
admet-1513	1315	27	cronce	cronce	NOUN
admet-1513	1315	28	,	,	PUNCT
admet-1513	1315	29	t.	t.	PROPN
admet-1513	1315	30	huffstater	huffstater	PROPN
admet-1513	1315	31	,	,	PUNCT
admet-1513	1315	32	s.s.f	s.s.f	PROPN
admet-1513	1315	33	.	.	PROPN
admet-1513	1315	34	jeanty	jeanty	PROPN
admet-1513	1315	35	,	,	PUNCT
admet-1513	1315	36	m.	m.	PROPN
admet-1513	1315	37	ingram	ingram	PROPN
admet-1513	1315	38	,	,	PUNCT
admet-1513	1315	39	a.	a.	NOUN
admet-1513	1315	40	chalkiadaki	chalkiadaki	PROPN
admet-1513	1315	41	,	,	PUNCT
admet-1513	1315	42	d.	d.	PROPN
admet-1513	1315	43	benson	benson	PROPN
admet-1513	1315	44	chou	chou	PROPN
admet-1513	1315	45	,	,	PUNCT
admet-1513	1315	46	s.	s.	PROPN
admet-1513	1315	47	marquez	marquez	PROPN
admet-1513	1315	48	,	,	PUNCT
admet-1513	1315	49	a.	a.	NOUN
admet-1513	1315	50	delahanty	delahanty	PROPN
admet-1513	1315	51	,	,	PUNCT
admet-1513	1315	52	s.	s.	PROPN
admet-1513	1315	53	jalilifiroozinezhad	jalilifiroozinezhad	PROPN
admet-1513	1315	54	,	,	PUNCT
admet-1513	1315	55	y.	y.	PROPN
admet-1513	1315	56	milton	milton	PROPN
admet-1513	1315	57	,	,	PUNCT
admet-1513	1315	58	a.	a.	PROPN
admet-1513	1315	59	sontheimer	sontheimer	PROPN
admet-1513	1315	60	-	-	PUNCT
admet-1513	1315	61	phelps	phelps	PROPN
admet-1513	1315	62	,	,	PUNCT
admet-1513	1315	63	b.	b.	PROPN
admet-1513	1315	64	swenor	swenor	PROPN
admet-1513	1315	65	,	,	PUNCT
admet-1513	1315	66	o.	o.	PROPN
admet-1513	1315	67	levy	levy	NOUN
admet-1513	1315	68	,	,	PUNCT
admet-1513	1315	69	k.k	k.k	PROPN
admet-1513	1315	70	.	.	PROPN
admet-1513	1315	71	parker	parker	PROPN
admet-1513	1315	72	,	,	PUNCT
admet-1513	1315	73	a.	a.	PROPN
admet-1513	1315	74	przekwas	przekwas	PROPN
admet-1513	1315	75	,	,	PUNCT
admet-1513	1315	76	d.e	d.e	PROPN
admet-1513	1315	77	.	.	PROPN
admet-1513	1315	78	ingber	ingber	PROPN
admet-1513	1315	79	.	.	PUNCT
admet-1513	1316	1	quantitative	quantitative	ADJ
admet-1513	1316	2	prediction	prediction	NOUN
admet-1513	1316	3	of	of	ADP
admet-1513	1316	4	human	human	ADJ
admet-1513	1316	5	pharmacokinetic	pharmacokinetic	ADJ
admet-1513	1316	6	responses	response	NOUN
admet-1513	1316	7	to	to	ADP
admet-1513	1316	8	drugs	drug	NOUN
admet-1513	1316	9	via	via	ADP
admet-1513	1316	10	fluidically	fluidically	ADV
admet-1513	1316	11	coupled	couple	VERB
admet-1513	1316	12	vascularized	vascularized	ADJ
admet-1513	1316	13	organ	organ	NOUN
admet-1513	1316	14	chips	chip	NOUN
admet-1513	1316	15	.	.	PUNCT
admet-1513	1317	1	nat	nat	PROPN
admet-1513	1317	2	.	.	PROPN
admet-1513	1317	3	biomed	biome	VERB
admet-1513	1317	4	.	.	PUNCT
admet-1513	1318	1	eng	eng	PROPN
admet-1513	1318	2	.	.	PROPN
admet-1513	1318	3	4	4	NUM
admet-1513	1318	4	(	(	PUNCT
admet-1513	1318	5	2020	2020	NUM
admet-1513	1318	6	)	)	PUNCT
admet-1513	1318	7	421	421	NUM
admet-1513	1318	8	-	-	SYM
admet-1513	1318	9	436	436	NUM
admet-1513	1318	10	.	.	PUNCT
admet-1513	1319	1	https://doi.org/10.1038/s41551-0190498-9	https://doi.org/10.1038/s41551-0190498-9	PROPN
admet-1513	1319	2	.	.	PUNCT
admet-1513	1320	1	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	1320	2	https://doi.org/10.1371/journal.pone.0158674	https://doi.org/10.1371/journal.pone.0158674	PROPN
admet-1513	1320	3	https://doi.org/10.1016/j.yexcr.2017.12.023	https://doi.org/10.1016/j.yexcr.2017.12.023	NUM
admet-1513	1320	4	https://doi.org/10.3390/ijms221910471	https://doi.org/10.3390/ijms221910471	PROPN
admet-1513	1320	5	https://doi.org/10.1016/j.jhep.2019.06.030	https://doi.org/10.1016/j.jhep.2019.06.030	PROPN
admet-1513	1320	6	https://doi.org/10.1016/j.jhep.2019.06.030	https://doi.org/10.1016/j.jhep.2019.06.030	PROPN
admet-1513	1320	7	https://doi.org/10.1016/j.jhep.2019.06.030	https://doi.org/10.1016/j.jhep.2019.06.030	PROPN
admet-1513	1320	8	https://doi.org/10.1038/nature12271	https://doi.org/10.1038/nature12271	VERB
admet-1513	1320	9	https://doi.org/10.1016/j.celrep.2017.11.005	https://doi.org/10.1016/j.celrep.2017.11.005	PROPN
admet-1513	1320	10	https://doi.org/10.1038/s41598-019-45514-3	https://doi.org/10.1038/s41598-019-45514-3	PROPN
admet-1513	1320	11	https://doi.org/10.1172/jci.insight.94954	https://doi.org/10.1172/jci.insight.94954	PROPN
admet-1513	1320	12	https://doi.org/10.1016/j.jhep.2018.12.028	https://doi.org/10.1016/j.jhep.2018.12.028	PROPN
admet-1513	1320	13	https://doi.org/10.1016/j.cmet.2019.05.007	https://doi.org/10.1016/j.cmet.2019.05.007	PROPN
admet-1513	1320	14	https://doi.org/10.1208/s12248-017-0122-4	https://doi.org/10.1208/s12248-017-0122-4	NUM
admet-1513	1321	1	https://doi.org/10.1038/s41551-019-0498-9	https://doi.org/10.1038/s41551-019-0498-9	NUM
admet-1513	1321	2	https://doi.org/10.1038/s41551-019-0498-9	https://doi.org/10.1038/s41551-019-0498-9	NUM
admet-1513	1321	3	venkatesh	venkatesh	PROPN
admet-1513	1321	4	chunduri	chunduri	NOUN
admet-1513	1321	5	and	and	CCONJ
admet-1513	1321	6	srinivas	srinivas	PROPN
admet-1513	1321	7	maddi	maddi	PROPN
admet-1513	1321	8	admet	admet	PROPN
admet-1513	1321	9	&	&	CCONJ
admet-1513	1321	10	dmpk	dmpk	PROPN
admet-1513	1321	11	11(1	11(1	NUM
admet-1513	1321	12	)	)	PUNCT
admet-1513	1321	13	(	(	PUNCT
admet-1513	1321	14	2023	2023	NUM
admet-1513	1321	15	)	)	PUNCT
admet-1513	1321	16	1	1	NUM
admet-1513	1321	17	-	-	SYM
admet-1513	1321	18	32	32	NUM
admet-1513	1321	19	28	28	NUM
admet-1513	1322	1	[	[	X
admet-1513	1322	2	157	157	NUM
admet-1513	1322	3	]	]	X
admet-1513	1322	4	q.	q.	PROPN
admet-1513	1322	5	ramadan	ramadan	PROPN
admet-1513	1322	6	,	,	PUNCT
admet-1513	1322	7	r.s	r.s	PROPN
admet-1513	1322	8	.	.	PROPN
admet-1513	1322	9	fardous	fardous	PROPN
admet-1513	1322	10	,	,	PUNCT
admet-1513	1322	11	r.	r.	PROPN
admet-1513	1322	12	hazaymeh	hazaymeh	PROPN
admet-1513	1322	13	,	,	PUNCT
admet-1513	1322	14	s.	s.	PROPN
admet-1513	1322	15	alshmmari	alshmmari	PROPN
admet-1513	1322	16	,	,	PUNCT
admet-1513	1322	17	m.	m.	NOUN
admet-1513	1322	18	zourob	zourob	PROPN
admet-1513	1322	19	.	.	PUNCT
admet-1513	1323	1	pharmacokinetics	pharmacokinetic	NOUN
admet-1513	1323	2	-	-	PUNCT
admet-1513	1323	3	on	on	ADP
admet-1513	1323	4	-	-	PUNCT
admet-1513	1323	5	a	a	DET
admet-1513	1323	6	-	-	PUNCT
admet-1513	1323	7	chip	chip	NOUN
admet-1513	1323	8	:	:	PUNCT
admet-1513	1323	9	in	in	ADP
admet-1513	1323	10	vitro	vitro	X
admet-1513	1323	11	microphysiological	microphysiological	ADJ
admet-1513	1323	12	models	model	NOUN
admet-1513	1323	13	for	for	ADP
admet-1513	1323	14	emulating	emulate	VERB
admet-1513	1323	15	of	of	ADP
admet-1513	1323	16	drugs	drug	NOUN
admet-1513	1323	17	adme	adme	NOUN
admet-1513	1323	18	.	.	PUNCT
admet-1513	1324	1	adv	adv	PROPN
admet-1513	1324	2	.	.	PUNCT
admet-1513	1325	1	biol	biol	PROPN
admet-1513	1325	2	.	.	PUNCT
admet-1513	1326	1	(	(	PUNCT
admet-1513	1326	2	weinh	weinh	NOUN
admet-1513	1326	3	)	)	PUNCT
admet-1513	1326	4	5	5	NUM
admet-1513	1326	5	(	(	PUNCT
admet-1513	1326	6	2021	2021	NUM
admet-1513	1326	7	)	)	PUNCT
admet-1513	1326	8	e2100775	e2100775	NOUN
admet-1513	1326	9	.	.	PUNCT
admet-1513	1327	1	https://doi.org/10.1002/adbi.202100775	https://doi.org/10.1002/adbi.202100775	NOUN
admet-1513	1327	2	.	.	PUNCT
admet-1513	1328	1	[	[	X
admet-1513	1328	2	158	158	NUM
admet-1513	1328	3	]	]	PUNCT
admet-1513	1328	4	k.	k.	PROPN
admet-1513	1328	5	haase	haase	PROPN
admet-1513	1328	6	,	,	PUNCT
admet-1513	1328	7	r.d	r.d	PROPN
admet-1513	1328	8	.	.	PROPN
admet-1513	1328	9	kamm	kamm	PROPN
admet-1513	1328	10	.	.	PROPN
admet-1513	1329	1	advances	advance	NOUN
admet-1513	1329	2	in	in	ADP
admet-1513	1329	3	on	on	ADP
admet-1513	1329	4	-	-	PUNCT
admet-1513	1329	5	chip	chip	NOUN
admet-1513	1329	6	vascularization	vascularization	NOUN
admet-1513	1329	7	.	.	PUNCT
admet-1513	1330	1	regen	regen	AUX
admet-1513	1330	2	.	.	PUNCT
admet-1513	1330	3	med	med	PROPN
admet-1513	1330	4	.	.	PROPN
admet-1513	1331	1	12	12	NUM
admet-1513	1331	2	(	(	PUNCT
admet-1513	1331	3	2017	2017	NUM
admet-1513	1331	4	)	)	PUNCT
admet-1513	1331	5	285	285	NUM
admet-1513	1331	6	-	-	SYM
admet-1513	1331	7	302	302	NUM
admet-1513	1331	8	.	.	PUNCT
admet-1513	1331	9	https://doi.org/10.2217/rme-2016-0152	https://doi.org/10.2217/rme-2016-0152	PROPN
admet-1513	1331	10	.	.	PUNCT
admet-1513	1332	1	[	[	X
admet-1513	1332	2	159	159	NUM
admet-1513	1332	3	]	]	X
admet-1513	1332	4	d.	d.	PROPN
admet-1513	1332	5	bavli	bavli	PROPN
admet-1513	1332	6	,	,	PUNCT
admet-1513	1332	7	s.	s.	PROPN
admet-1513	1332	8	prill	prill	PROPN
admet-1513	1332	9	,	,	PUNCT
admet-1513	1332	10	e.	e.	PROPN
admet-1513	1332	11	ezra	ezra	PROPN
admet-1513	1332	12	,	,	PUNCT
admet-1513	1332	13	g.	g.	PROPN
admet-1513	1332	14	levy	levy	PROPN
admet-1513	1332	15	,	,	PUNCT
admet-1513	1332	16	m.	m.	NOUN
admet-1513	1332	17	cohen	cohen	PROPN
admet-1513	1332	18	,	,	PUNCT
admet-1513	1332	19	m.	m.	PROPN
admet-1513	1332	20	vinken	vinken	VERB
admet-1513	1332	21	,	,	PUNCT
admet-1513	1332	22	j.	j.	PROPN
admet-1513	1332	23	vanfleteren	vanfleteren	PROPN
admet-1513	1332	24	,	,	PUNCT
admet-1513	1332	25	m.	m.	NOUN
admet-1513	1332	26	jaeger	jaeger	NOUN
admet-1513	1332	27	,	,	PUNCT
admet-1513	1332	28	y.	y.	PROPN
admet-1513	1332	29	nahmias	nahmias	PROPN
admet-1513	1332	30	.	.	PUNCT
admet-1513	1333	1	realtime	realtime	ADJ
admet-1513	1333	2	monitoring	monitoring	NOUN
admet-1513	1333	3	of	of	ADP
admet-1513	1333	4	metabolic	metabolic	NOUN
admet-1513	1333	5	function	function	NOUN
admet-1513	1333	6	in	in	ADP
admet-1513	1333	7	liver	liver	NOUN
admet-1513	1333	8	-	-	PUNCT
admet-1513	1333	9	on	on	ADP
admet-1513	1333	10	-	-	PUNCT
admet-1513	1333	11	chip	chip	NOUN
admet-1513	1333	12	microdevices	microdevice	NOUN
admet-1513	1333	13	tracks	track	VERB
admet-1513	1333	14	the	the	DET
admet-1513	1333	15	dynamics	dynamic	NOUN
admet-1513	1333	16	of	of	ADP
admet-1513	1333	17	mitochondrial	mitochondrial	ADJ
admet-1513	1333	18	dysfunction	dysfunction	NOUN
admet-1513	1333	19	.	.	PUNCT
admet-1513	1334	1	proc	proc	NOUN
admet-1513	1334	2	.	.	PUNCT
admet-1513	1335	1	natl	natl	PROPN
admet-1513	1335	2	.	.	PUNCT
admet-1513	1336	1	acad	acad	PROPN
admet-1513	1336	2	.	.	PUNCT
admet-1513	1337	1	sci	sci	PROPN
admet-1513	1337	2	.	.	PROPN
admet-1513	1337	3	usa	usa	PROPN
admet-1513	1337	4	113	113	NUM
admet-1513	1337	5	(	(	PUNCT
admet-1513	1337	6	2016	2016	NUM
admet-1513	1337	7	)	)	PUNCT
admet-1513	1337	8	e2231	e2231	PROPN
admet-1513	1337	9	-	-	PUNCT
admet-1513	1337	10	40	40	NUM
admet-1513	1337	11	.	.	PUNCT
admet-1513	1337	12	https://doi.org/10.1073/pnas.1522556113	https://doi.org/10.1073/pnas.1522556113	NOUN
admet-1513	1337	13	.	.	PUNCT
admet-1513	1338	1	[	[	X
admet-1513	1338	2	160	160	NUM
admet-1513	1338	3	]	]	X
admet-1513	1338	4	k.j	k.j	PROPN
admet-1513	1338	5	.	.	PROPN
admet-1513	1338	6	jang	jang	PROPN
admet-1513	1338	7	,	,	PUNCT
admet-1513	1338	8	m.a	m.a	PROPN
admet-1513	1338	9	.	.	PROPN
admet-1513	1338	10	otieno	otieno	PROPN
admet-1513	1338	11	,	,	PUNCT
admet-1513	1338	12	j.	j.	PROPN
admet-1513	1338	13	ronxhi	ronxhi	PROPN
admet-1513	1338	14	,	,	PUNCT
admet-1513	1338	15	h.k	h.k	PROPN
admet-1513	1338	16	.	.	PROPN
admet-1513	1338	17	lim	lim	PROPN
admet-1513	1338	18	,	,	PUNCT
admet-1513	1338	19	l.	l.	PROPN
admet-1513	1338	20	ewart	ewart	PROPN
admet-1513	1338	21	,	,	PUNCT
admet-1513	1338	22	k.r	k.r	PROPN
admet-1513	1338	23	.	.	PROPN
admet-1513	1338	24	kodella	kodella	PROPN
admet-1513	1338	25	,	,	PUNCT
admet-1513	1338	26	d.b	d.b	PROPN
admet-1513	1338	27	.	.	PROPN
admet-1513	1338	28	petropolis	petropolis	PROPN
admet-1513	1338	29	,	,	PUNCT
admet-1513	1338	30	g.	g.	PROPN
admet-1513	1338	31	kulkarni	kulkarni	PROPN
admet-1513	1338	32	,	,	PUNCT
admet-1513	1338	33	j.e	j.e	PROPN
admet-1513	1338	34	.	.	PROPN
admet-1513	1338	35	rubins	rubin	NOUN
admet-1513	1338	36	,	,	PUNCT
admet-1513	1338	37	d.	d.	PROPN
admet-1513	1338	38	conegliano	conegliano	PROPN
admet-1513	1338	39	,	,	PUNCT
admet-1513	1338	40	j.	j.	PROPN
admet-1513	1338	41	nawroth	nawroth	PROPN
admet-1513	1338	42	,	,	PUNCT
admet-1513	1338	43	d.	d.	PROPN
admet-1513	1338	44	simic	simic	PROPN
admet-1513	1338	45	,	,	PUNCT
admet-1513	1338	46	w.	w.	PROPN
admet-1513	1338	47	lam	lam	PROPN
admet-1513	1338	48	,	,	PUNCT
admet-1513	1338	49	m.	m.	NOUN
admet-1513	1338	50	singer	singer	NOUN
admet-1513	1338	51	,	,	PUNCT
admet-1513	1338	52	e.	e.	PROPN
admet-1513	1338	53	barale	barale	PROPN
admet-1513	1338	54	,	,	PUNCT
admet-1513	1338	55	b.	b.	PROPN
admet-1513	1338	56	singh	singh	PROPN
admet-1513	1338	57	,	,	PUNCT
admet-1513	1338	58	m.	m.	NOUN
admet-1513	1338	59	sonee	sonee	NOUN
admet-1513	1338	60	,	,	PUNCT
admet-1513	1338	61	a.j	a.j	PROPN
admet-1513	1338	62	.	.	PROPN
admet-1513	1338	63	streeter	streeter	PROPN
admet-1513	1338	64	,	,	PUNCT
admet-1513	1338	65	c.	c.	PROPN
admet-1513	1338	66	manthey	manthey	PROPN
admet-1513	1338	67	,	,	PUNCT
admet-1513	1338	68	b.	b.	PROPN
admet-1513	1338	69	jones	jones	PROPN
admet-1513	1338	70	,	,	PUNCT
admet-1513	1338	71	a.	a.	PROPN
admet-1513	1338	72	srivastava	srivastava	PROPN
admet-1513	1338	73	,	,	PUNCT
admet-1513	1338	74	l.c	l.c	PROPN
admet-1513	1338	75	.	.	PROPN
admet-1513	1338	76	andersson	andersson	PROPN
admet-1513	1338	77	,	,	PUNCT
admet-1513	1338	78	d.	d.	PROPN
admet-1513	1338	79	williams	williams	PROPN
admet-1513	1338	80	,	,	PUNCT
admet-1513	1338	81	h.	h.	PROPN
admet-1513	1338	82	park	park	PROPN
admet-1513	1338	83	,	,	PUNCT
admet-1513	1338	84	r.	r.	PROPN
admet-1513	1338	85	barrile	barrile	PROPN
admet-1513	1338	86	,	,	PUNCT
admet-1513	1338	87	j.	j.	PROPN
admet-1513	1338	88	sliz	sliz	PROPN
admet-1513	1338	89	,	,	PUNCT
admet-1513	1338	90	a.	a.	NOUN
admet-1513	1338	91	herland	herland	PROPN
admet-1513	1338	92	,	,	PUNCT
admet-1513	1338	93	s.	s.	PROPN
admet-1513	1338	94	haney	haney	PROPN
admet-1513	1338	95	,	,	PUNCT
admet-1513	1338	96	k.	k.	PROPN
admet-1513	1338	97	karalis	karalis	PROPN
admet-1513	1338	98	,	,	PUNCT
admet-1513	1338	99	d.e	d.e	PROPN
admet-1513	1338	100	.	.	PROPN
admet-1513	1338	101	ingber	ingber	PROPN
admet-1513	1338	102	,	,	PUNCT
admet-1513	1338	103	g.a	g.a	PROPN
admet-1513	1338	104	.	.	PROPN
admet-1513	1338	105	hamilton	hamilton	PROPN
admet-1513	1338	106	.	.	PUNCT
admet-1513	1339	1	reproducing	reproduce	VERB
admet-1513	1339	2	human	human	ADJ
admet-1513	1339	3	and	and	CCONJ
admet-1513	1339	4	cross	cross	ADJ
admet-1513	1339	5	-	-	ADJ
admet-1513	1339	6	species	species	ADJ
admet-1513	1339	7	drug	drug	NOUN
admet-1513	1339	8	toxicities	toxicity	NOUN
admet-1513	1339	9	using	use	VERB
admet-1513	1339	10	a	a	DET
admet-1513	1339	11	liver	liver	NOUN
admet-1513	1339	12	-	-	PUNCT
admet-1513	1339	13	chip	chip	NOUN
admet-1513	1339	14	.	.	PUNCT
admet-1513	1340	1	sci	sci	PROPN
admet-1513	1340	2	.	.	PROPN
admet-1513	1340	3	transl	transl	PROPN
admet-1513	1340	4	.	.	PUNCT
admet-1513	1341	1	med	med	PROPN
admet-1513	1341	2	.	.	PROPN
admet-1513	1342	1	11	11	NUM
admet-1513	1342	2	(	(	PUNCT
admet-1513	1342	3	2019	2019	NUM
admet-1513	1342	4	)	)	PUNCT
admet-1513	1343	1	eaax5516	eaax5516	PROPN
admet-1513	1343	2	.	.	PUNCT
admet-1513	1344	1	https://doi.org/10.1126/scitranslmed.aax5516	https://doi.org/10.1126/scitranslmed.aax5516	PROPN
admet-1513	1344	2	.	.	PUNCT
admet-1513	1345	1	[	[	X
admet-1513	1345	2	161	161	NUM
admet-1513	1345	3	]	]	X
admet-1513	1345	4	y.	y.	PROPN
admet-1513	1345	5	wang	wang	PROPN
admet-1513	1345	6	,	,	PUNCT
admet-1513	1345	7	h.	h.	PROPN
admet-1513	1345	8	wang	wang	PROPN
admet-1513	1345	9	,	,	PUNCT
admet-1513	1345	10	p.	p.	PROPN
admet-1513	1345	11	deng	deng	PROPN
admet-1513	1345	12	,	,	PUNCT
admet-1513	1345	13	w.	w.	PROPN
admet-1513	1345	14	chen	chen	PROPN
admet-1513	1345	15	,	,	PUNCT
admet-1513	1345	16	y.	y.	PROPN
admet-1513	1345	17	guo	guo	PROPN
admet-1513	1345	18	,	,	PUNCT
admet-1513	1345	19	t.	t.	PROPN
admet-1513	1345	20	tao	tao	PROPN
admet-1513	1345	21	,	,	PUNCT
admet-1513	1345	22	j.	j.	PROPN
admet-1513	1345	23	qin	qin	PROPN
admet-1513	1345	24	.	.	PUNCT
admet-1513	1346	1	in	in	ADP
admet-1513	1346	2	situ	situ	ADJ
admet-1513	1346	3	differentiation	differentiation	NOUN
admet-1513	1346	4	and	and	CCONJ
admet-1513	1346	5	generation	generation	NOUN
admet-1513	1346	6	of	of	ADP
admet-1513	1346	7	functional	functional	ADJ
admet-1513	1346	8	liver	liver	NOUN
admet-1513	1346	9	organoids	organoid	NOUN
admet-1513	1346	10	from	from	ADP
admet-1513	1346	11	human	human	ADJ
admet-1513	1346	12	ipscs	ipsc	NOUN
admet-1513	1346	13	in	in	ADP
admet-1513	1346	14	a	a	DET
admet-1513	1346	15	3d	3d	PROPN
admet-1513	1346	16	perfusable	perfusable	ADJ
admet-1513	1346	17	chip	chip	NOUN
admet-1513	1346	18	system	system	NOUN
admet-1513	1346	19	.	.	PUNCT
admet-1513	1347	1	lab	lab	NOUN
admet-1513	1347	2	chip	chip	NOUN
admet-1513	1347	3	18	18	NUM
admet-1513	1347	4	(	(	PUNCT
admet-1513	1347	5	2018	2018	NUM
admet-1513	1347	6	)	)	PUNCT
admet-1513	1347	7	36063616	36063616	NUM
admet-1513	1347	8	.	.	PUNCT
admet-1513	1348	1	https://doi.org/10.1039/c8lc00869h	https://doi.org/10.1039/c8lc00869h	NOUN
admet-1513	1348	2	.	.	PUNCT
admet-1513	1349	1	[	[	X
admet-1513	1349	2	162	162	NUM
admet-1513	1349	3	]	]	X
admet-1513	1349	4	j.h	j.h	PROPN
admet-1513	1349	5	.	.	PROPN
admet-1513	1349	6	hoofnagle	hoofnagle	PROPN
admet-1513	1349	7	,	,	PUNCT
admet-1513	1349	8	e.s	e.s	PROPN
admet-1513	1349	9	.	.	PROPN
admet-1513	1349	10	björnsson	björnsson	PROPN
admet-1513	1349	11	.	.	PUNCT
admet-1513	1350	1	drug	drug	NOUN
admet-1513	1350	2	-	-	PUNCT
admet-1513	1350	3	induced	induce	VERB
admet-1513	1350	4	liver	liver	NOUN
admet-1513	1350	5	injury	injury	NOUN
admet-1513	1350	6	types	type	NOUN
admet-1513	1350	7	and	and	CCONJ
admet-1513	1350	8	phenotypes	phenotype	NOUN
admet-1513	1350	9	.	.	PUNCT
admet-1513	1351	1	n.	n.	PROPN
admet-1513	1351	2	engl	engl	PROPN
admet-1513	1351	3	.	.	PUNCT
admet-1513	1352	1	j.	j.	PROPN
admet-1513	1352	2	med	med	PROPN
admet-1513	1352	3	.	.	PUNCT
admet-1513	1353	1	381	381	NUM
admet-1513	1353	2	(	(	PUNCT
admet-1513	1353	3	2019	2019	NUM
admet-1513	1353	4	)	)	PUNCT
admet-1513	1353	5	264	264	NUM
admet-1513	1353	6	-	-	SYM
admet-1513	1353	7	273	273	NUM
admet-1513	1353	8	.	.	PUNCT
admet-1513	1354	1	https://doi.org/10.1056/nejmra1816149	https://doi.org/10.1056/nejmra1816149	NOUN
admet-1513	1354	2	.	.	PUNCT
admet-1513	1355	1	[	[	X
admet-1513	1355	2	163	163	NUM
admet-1513	1355	3	]	]	X
admet-1513	1355	4	d.	d.	PROPN
admet-1513	1355	5	cook	cook	PROPN
admet-1513	1355	6	,	,	PUNCT
admet-1513	1355	7	d.	d.	PROPN
admet-1513	1355	8	brown	brown	PROPN
admet-1513	1355	9	,	,	PUNCT
admet-1513	1355	10	r.	r.	PROPN
admet-1513	1355	11	alexander	alexander	PROPN
admet-1513	1355	12	,	,	PUNCT
admet-1513	1355	13	r.	r.	PROPN
admet-1513	1355	14	march	march	PROPN
admet-1513	1355	15	,	,	PUNCT
admet-1513	1355	16	p.	p.	PROPN
admet-1513	1355	17	morgan	morgan	PROPN
admet-1513	1355	18	,	,	PUNCT
admet-1513	1355	19	g.	g.	PROPN
admet-1513	1355	20	satterthwaite	satterthwaite	PROPN
admet-1513	1355	21	,	,	PUNCT
admet-1513	1355	22	m.n	m.n	PROPN
admet-1513	1355	23	.	.	PROPN
admet-1513	1355	24	pangalos	pangalo	NOUN
admet-1513	1355	25	.	.	PUNCT
admet-1513	1356	1	lessons	lesson	NOUN
admet-1513	1356	2	learned	learn	VERB
admet-1513	1356	3	from	from	ADP
admet-1513	1356	4	the	the	DET
admet-1513	1356	5	fate	fate	NOUN
admet-1513	1356	6	of	of	ADP
admet-1513	1356	7	astrazeneca	astrazeneca	PROPN
admet-1513	1356	8	's	's	PART
admet-1513	1356	9	drug	drug	NOUN
admet-1513	1356	10	pipeline	pipeline	NOUN
admet-1513	1356	11	:	:	PUNCT
admet-1513	1356	12	a	a	DET
admet-1513	1356	13	five	five	NUM
admet-1513	1356	14	-	-	PUNCT
admet-1513	1356	15	dimensional	dimensional	ADJ
admet-1513	1356	16	framework	framework	NOUN
admet-1513	1356	17	.	.	PUNCT
admet-1513	1357	1	nat	nat	PROPN
admet-1513	1357	2	.	.	PUNCT
admet-1513	1358	1	rev	rev	PROPN
admet-1513	1358	2	.	.	PROPN
admet-1513	1358	3	drug	drug	NOUN
admet-1513	1358	4	discov	discov	NOUN
admet-1513	1358	5	.	.	PUNCT
admet-1513	1359	1	13	13	NUM
admet-1513	1359	2	(	(	PUNCT
admet-1513	1359	3	2014	2014	NUM
admet-1513	1359	4	)	)	PUNCT
admet-1513	1359	5	419	419	NUM
admet-1513	1359	6	-	-	SYM
admet-1513	1359	7	431	431	NUM
admet-1513	1359	8	.	.	PUNCT
admet-1513	1360	1	https://doi.org/10.1038/nrd4309	https://doi.org/10.1038/nrd4309	NOUN
admet-1513	1360	2	.	.	PUNCT
admet-1513	1361	1	[	[	X
admet-1513	1361	2	164	164	NUM
admet-1513	1361	3	]	]	X
admet-1513	1361	4	h.	h.	PROPN
admet-1513	1361	5	olson	olson	PROPN
admet-1513	1361	6	,	,	PUNCT
admet-1513	1361	7	g.	g.	PROPN
admet-1513	1361	8	betton	betton	PROPN
admet-1513	1361	9	,	,	PUNCT
admet-1513	1361	10	d.	d.	PROPN
admet-1513	1361	11	robinson	robinson	PROPN
admet-1513	1361	12	,	,	PUNCT
admet-1513	1361	13	k.	k.	PROPN
admet-1513	1361	14	thomas	thomas	PROPN
admet-1513	1361	15	,	,	PUNCT
admet-1513	1361	16	a.	a.	PROPN
admet-1513	1361	17	monro	monro	PROPN
admet-1513	1361	18	,	,	PUNCT
admet-1513	1361	19	g.	g.	PROPN
admet-1513	1361	20	kolaja	kolaja	PROPN
admet-1513	1361	21	,	,	PUNCT
admet-1513	1361	22	p.	p.	PROPN
admet-1513	1361	23	lilly	lilly	PROPN
admet-1513	1361	24	,	,	PUNCT
admet-1513	1361	25	j.	j.	PROPN
admet-1513	1361	26	sanders	sanders	PROPN
admet-1513	1361	27	,	,	PUNCT
admet-1513	1361	28	g.	g.	PROPN
admet-1513	1361	29	sipes	sipes	PROPN
admet-1513	1361	30	,	,	PUNCT
admet-1513	1361	31	w.	w.	PROPN
admet-1513	1361	32	bracken	bracken	PROPN
admet-1513	1361	33	,	,	PUNCT
admet-1513	1361	34	m.	m.	NOUN
admet-1513	1361	35	dorato	dorato	PROPN
admet-1513	1361	36	,	,	PUNCT
admet-1513	1361	37	k.	k.	PROPN
admet-1513	1361	38	van	van	PROPN
admet-1513	1361	39	deun	deun	NOUN
admet-1513	1361	40	,	,	PUNCT
admet-1513	1361	41	p.	p.	PROPN
admet-1513	1361	42	smith	smith	PROPN
admet-1513	1361	43	,	,	PUNCT
admet-1513	1361	44	b.	b.	PROPN
admet-1513	1361	45	berger	berger	PROPN
admet-1513	1361	46	,	,	PUNCT
admet-1513	1361	47	a.	a.	NOUN
admet-1513	1361	48	heller	heller	PROPN
admet-1513	1361	49	.	.	PROPN
admet-1513	1362	1	concordance	concordance	NOUN
admet-1513	1362	2	of	of	ADP
admet-1513	1362	3	the	the	DET
admet-1513	1362	4	toxicity	toxicity	NOUN
admet-1513	1362	5	of	of	ADP
admet-1513	1362	6	pharmaceuticals	pharmaceutical	NOUN
admet-1513	1362	7	in	in	ADP
admet-1513	1362	8	humans	human	NOUN
admet-1513	1362	9	and	and	CCONJ
admet-1513	1362	10	in	in	ADP
admet-1513	1362	11	animals	animal	NOUN
admet-1513	1362	12	.	.	PUNCT
admet-1513	1363	1	regul	regul	NOUN
admet-1513	1363	2	.	.	PUNCT
admet-1513	1364	1	toxicol	toxicol	PROPN
admet-1513	1364	2	.	.	PUNCT
admet-1513	1365	1	pharmacol	pharmacol	PROPN
admet-1513	1365	2	.	.	PUNCT
admet-1513	1366	1	32	32	NUM
admet-1513	1366	2	(	(	PUNCT
admet-1513	1366	3	2000	2000	NUM
admet-1513	1366	4	)	)	PUNCT
admet-1513	1366	5	56	56	NUM
admet-1513	1366	6	-	-	SYM
admet-1513	1366	7	67	67	NUM
admet-1513	1366	8	.	.	PUNCT
admet-1513	1367	1	https://doi.org/10.1006/rtph.2000.1399	https://doi.org/10.1006/rtph.2000.1399	PROPN
admet-1513	1367	2	.	.	PUNCT
admet-1513	1368	1	[	[	X
admet-1513	1368	2	165	165	NUM
admet-1513	1368	3	]	]	PUNCT
admet-1513	1368	4	j.	j.	PROPN
admet-1513	1368	5	kim	kim	PROPN
admet-1513	1368	6	,	,	PUNCT
admet-1513	1368	7	b.k	b.k	PROPN
admet-1513	1368	8	.	.	PROPN
admet-1513	1368	9	koo	koo	PROPN
admet-1513	1368	10	,	,	PUNCT
admet-1513	1368	11	j.a	j.a	PROPN
admet-1513	1368	12	.	.	PROPN
admet-1513	1368	13	knoblich	knoblich	PROPN
admet-1513	1368	14	.	.	PUNCT
admet-1513	1369	1	human	human	ADJ
admet-1513	1369	2	organoids	organoid	NOUN
admet-1513	1369	3	:	:	PUNCT
admet-1513	1369	4	model	model	NOUN
admet-1513	1369	5	systems	system	NOUN
admet-1513	1369	6	for	for	ADP
admet-1513	1369	7	human	human	ADJ
admet-1513	1369	8	biology	biology	NOUN
admet-1513	1369	9	and	and	CCONJ
admet-1513	1369	10	medicine	medicine	NOUN
admet-1513	1369	11	.	.	PUNCT
admet-1513	1370	1	nat	nat	PROPN
admet-1513	1370	2	rev	rev	PROPN
admet-1513	1370	3	.	.	PROPN
admet-1513	1370	4	mol	mol	PROPN
admet-1513	1370	5	.	.	PROPN
admet-1513	1370	6	cell	cell	PROPN
admet-1513	1370	7	biol	biol	PROPN
admet-1513	1370	8	.	.	PUNCT
admet-1513	1371	1	21	21	NUM
admet-1513	1371	2	(	(	PUNCT
admet-1513	1371	3	2020	2020	NUM
admet-1513	1371	4	)	)	PUNCT
admet-1513	1371	5	571	571	NUM
admet-1513	1371	6	-	-	SYM
admet-1513	1371	7	584	584	NUM
admet-1513	1371	8	.	.	PUNCT
admet-1513	1372	1	https://doi.org/10.1038/s41580-020-0259-3	https://doi.org/10.1038/s41580-020-0259-3	NUM
admet-1513	1372	2	.	.	PUNCT
admet-1513	1373	1	[	[	X
admet-1513	1373	2	166	166	NUM
admet-1513	1373	3	]	]	PUNCT
admet-1513	1373	4	m.	m.	NOUN
admet-1513	1373	5	sgodda	sgodda	NOUN
admet-1513	1373	6	,	,	PUNCT
admet-1513	1373	7	z.	z.	PROPN
admet-1513	1373	8	dai	dai	PROPN
admet-1513	1373	9	,	,	PUNCT
admet-1513	1373	10	r.	r.	PROPN
admet-1513	1373	11	zweigerdt	zweigerdt	PROPN
admet-1513	1373	12	,	,	PUNCT
admet-1513	1373	13	a.d	a.d	PROPN
admet-1513	1373	14	.	.	PROPN
admet-1513	1373	15	sharma	sharma	PROPN
admet-1513	1373	16	,	,	PUNCT
admet-1513	1373	17	m.	m.	PROPN
admet-1513	1373	18	ott	ott	PROPN
admet-1513	1373	19	,	,	PUNCT
admet-1513	1373	20	t.	t.	PROPN
admet-1513	1373	21	cantz	cantz	PROPN
admet-1513	1373	22	.	.	PUNCT
admet-1513	1374	1	a	a	DET
admet-1513	1374	2	scalable	scalable	ADJ
admet-1513	1374	3	approach	approach	NOUN
admet-1513	1374	4	for	for	ADP
admet-1513	1374	5	the	the	DET
admet-1513	1374	6	generation	generation	NOUN
admet-1513	1374	7	of	of	ADP
admet-1513	1374	8	human	human	ADJ
admet-1513	1374	9	pluripotent	pluripotent	NOUN
admet-1513	1374	10	stem	stem	NOUN
admet-1513	1374	11	cell	cell	NOUN
admet-1513	1374	12	-	-	PUNCT
admet-1513	1374	13	derived	derive	VERB
admet-1513	1374	14	hepatic	hepatic	ADJ
admet-1513	1374	15	organoids	organoid	NOUN
admet-1513	1374	16	with	with	ADP
admet-1513	1374	17	sensitive	sensitive	ADJ
admet-1513	1374	18	hepatotoxicity	hepatotoxicity	NOUN
admet-1513	1374	19	features	feature	NOUN
admet-1513	1374	20	.	.	PUNCT
admet-1513	1375	1	stem	stem	NOUN
admet-1513	1375	2	cells	cell	NOUN
admet-1513	1375	3	dev	dev	PROPN
admet-1513	1375	4	.	.	PROPN
admet-1513	1376	1	26	26	NUM
admet-1513	1376	2	(	(	PUNCT
admet-1513	1376	3	2017	2017	NUM
admet-1513	1376	4	)	)	PUNCT
admet-1513	1376	5	1490	1490	NUM
admet-1513	1376	6	-	-	SYM
admet-1513	1376	7	1504	1504	NUM
admet-1513	1376	8	.	.	PUNCT
admet-1513	1377	1	https://doi.org/10.1089/scd.2017.0023	https://doi.org/10.1089/scd.2017.0023	NOUN
admet-1513	1377	2	.	.	PUNCT
admet-1513	1378	1	[	[	X
admet-1513	1378	2	167	167	NUM
admet-1513	1378	3	]	]	X
admet-1513	1378	4	s.d	s.d	PROPN
admet-1513	1378	5	.	.	PROPN
admet-1513	1378	6	forsythe	forsythe	PROPN
admet-1513	1378	7	,	,	PUNCT
admet-1513	1378	8	m.	m.	NOUN
admet-1513	1378	9	devarasetty	devarasetty	PROPN
admet-1513	1378	10	,	,	PUNCT
admet-1513	1378	11	t.	t.	PROPN
admet-1513	1378	12	shupe	shupe	PROPN
admet-1513	1378	13	,	,	PUNCT
admet-1513	1378	14	c.	c.	PROPN
admet-1513	1378	15	bishop	bishop	PROPN
admet-1513	1378	16	,	,	PUNCT
admet-1513	1378	17	a.	a.	NOUN
admet-1513	1378	18	atala	atala	PROPN
admet-1513	1378	19	,	,	PUNCT
admet-1513	1378	20	s.	s.	PROPN
admet-1513	1378	21	soker	soker	PROPN
admet-1513	1378	22	,	,	PUNCT
admet-1513	1378	23	a.	a.	NOUN
admet-1513	1378	24	skardal	skardal	NOUN
admet-1513	1378	25	.	.	PUNCT
admet-1513	1379	1	environmental	environmental	ADJ
admet-1513	1379	2	toxin	toxin	NOUN
admet-1513	1379	3	screening	screen	VERB
admet-1513	1379	4	using	use	VERB
admet-1513	1379	5	human	human	NOUN
admet-1513	1379	6	-	-	PUNCT
admet-1513	1379	7	derived	derive	VERB
admet-1513	1379	8	3d	3d	NOUN
admet-1513	1379	9	bioengineered	bioengineere	VERB
admet-1513	1379	10	liver	liver	NOUN
admet-1513	1379	11	and	and	CCONJ
admet-1513	1379	12	cardiac	cardiac	ADJ
admet-1513	1379	13	organoids	organoid	NOUN
admet-1513	1379	14	.	.	PUNCT
admet-1513	1380	1	front	front	ADJ
admet-1513	1380	2	.	.	PUNCT
admet-1513	1381	1	public	public	ADJ
admet-1513	1381	2	.	.	PUNCT
admet-1513	1382	1	health	health	NOUN
admet-1513	1382	2	6	6	NUM
admet-1513	1382	3	(	(	PUNCT
admet-1513	1382	4	2018	2018	NUM
admet-1513	1382	5	)	)	PUNCT
admet-1513	1382	6	103	103	NUM
admet-1513	1382	7	.	.	PUNCT
admet-1513	1383	1	https://doi.org/10.3389/fpubh.2018.00103	https://doi.org/10.3389/fpubh.2018.00103	NOUN
admet-1513	1383	2	.	.	PUNCT
admet-1513	1384	1	[	[	X
admet-1513	1384	2	168	168	NUM
admet-1513	1384	3	]	]	X
admet-1513	1384	4	j.y	j.y	PROPN
admet-1513	1384	5	.	.	PROPN
admet-1513	1384	6	lee	lee	PROPN
admet-1513	1384	7	,	,	PUNCT
admet-1513	1384	8	h.j	h.j	PROPN
admet-1513	1384	9	.	.	PROPN
admet-1513	1384	10	han	han	PROPN
admet-1513	1384	11	,	,	PUNCT
admet-1513	1384	12	s.j	s.j	PROPN
admet-1513	1384	13	.	.	PROPN
admet-1513	1384	14	lee	lee	PROPN
admet-1513	1384	15	,	,	PUNCT
admet-1513	1384	16	e.h	e.h	PROPN
admet-1513	1384	17	.	.	PROPN
admet-1513	1384	18	cho	cho	PROPN
admet-1513	1384	19	,	,	PUNCT
admet-1513	1384	20	h.b	h.b	PROPN
admet-1513	1384	21	.	.	PROPN
admet-1513	1384	22	lee	lee	PROPN
admet-1513	1384	23	,	,	PUNCT
admet-1513	1384	24	j.h	j.h	PROPN
admet-1513	1384	25	.	.	PROPN
admet-1513	1384	26	seok	seok	PROPN
admet-1513	1384	27	,	,	PUNCT
admet-1513	1384	28	h.s	h.s	PROPN
admet-1513	1384	29	.	.	PROPN
admet-1513	1384	30	lim	lim	PROPN
admet-1513	1384	31	,	,	PUNCT
admet-1513	1384	32	w.c	w.c	PROPN
admet-1513	1384	33	.	.	PROPN
admet-1513	1384	34	son	son	PROPN
admet-1513	1384	35	.	.	PUNCT
admet-1513	1385	1	use	use	NOUN
admet-1513	1385	2	of	of	ADP
admet-1513	1385	3	3d	3d	PROPN
admet-1513	1385	4	human	human	ADJ
admet-1513	1385	5	liver	liver	NOUN
admet-1513	1385	6	organoids	organoid	NOUN
admet-1513	1385	7	to	to	PART
admet-1513	1385	8	predict	predict	VERB
admet-1513	1385	9	drug	drug	NOUN
admet-1513	1385	10	-	-	PUNCT
admet-1513	1385	11	induced	induce	VERB
admet-1513	1385	12	phospholipidosis	phospholipidosis	NOUN
admet-1513	1385	13	.	.	PUNCT
admet-1513	1386	1	int	int	NOUN
admet-1513	1386	2	.	.	PUNCT
admet-1513	1387	1	j.	j.	PROPN
admet-1513	1387	2	mol	mol	PROPN
admet-1513	1387	3	.	.	PUNCT
admet-1513	1388	1	sci	sci	PROPN
admet-1513	1388	2	.	.	PROPN
admet-1513	1388	3	21	21	NUM
admet-1513	1388	4	(	(	PUNCT
admet-1513	1388	5	2020	2020	NUM
admet-1513	1388	6	)	)	PUNCT
admet-1513	1389	1	e2982	e2982	PROPN
admet-1513	1389	2	.	.	PROPN
admet-1513	1389	3	https://doi.org/10.3390/ijms21082982	https://doi.org/10.3390/ijms21082982	PROPN
admet-1513	1389	4	.	.	PUNCT
admet-1513	1390	1	[	[	X
admet-1513	1390	2	169	169	NUM
admet-1513	1390	3	]	]	PUNCT
admet-1513	1390	4	t.	t.	PROPN
admet-1513	1390	5	shinozawa	shinozawa	PROPN
admet-1513	1390	6	,	,	PUNCT
admet-1513	1390	7	m.	m.	NOUN
admet-1513	1390	8	kimura	kimura	PROPN
admet-1513	1390	9	,	,	PUNCT
admet-1513	1390	10	y.	y.	PROPN
admet-1513	1390	11	cai	cai	PROPN
admet-1513	1390	12	,	,	PUNCT
admet-1513	1390	13	n.	n.	PROPN
admet-1513	1390	14	saiki	saiki	PROPN
admet-1513	1390	15	,	,	PUNCT
admet-1513	1390	16	y.	y.	PROPN
admet-1513	1390	17	yoneyama	yoneyama	PROPN
admet-1513	1390	18	,	,	PUNCT
admet-1513	1390	19	r.	r.	PROPN
admet-1513	1390	20	ouchi	ouchi	PROPN
admet-1513	1390	21	,	,	PUNCT
admet-1513	1390	22	h.	h.	PROPN
admet-1513	1390	23	koike	koike	PROPN
admet-1513	1390	24	,	,	PUNCT
admet-1513	1390	25	m.	m.	NOUN
admet-1513	1390	26	maezawa	maezawa	PROPN
admet-1513	1390	27	,	,	PUNCT
admet-1513	1390	28	r.r	r.r	PROPN
admet-1513	1390	29	.	.	PROPN
admet-1513	1390	30	zhang	zhang	PROPN
admet-1513	1390	31	,	,	PUNCT
admet-1513	1390	32	a.	a.	PROPN
admet-1513	1390	33	dunn	dunn	PROPN
admet-1513	1390	34	,	,	PUNCT
admet-1513	1390	35	a.	a.	PROPN
admet-1513	1390	36	ferguson	ferguson	PROPN
admet-1513	1390	37	,	,	PUNCT
admet-1513	1390	38	s.	s.	PROPN
admet-1513	1390	39	togo	togo	PROPN
admet-1513	1390	40	,	,	PUNCT
admet-1513	1390	41	k.	k.	PROPN
admet-1513	1390	42	lewis	lewis	PROPN
admet-1513	1390	43	,	,	PUNCT
admet-1513	1390	44	w.l	w.l	PROPN
admet-1513	1390	45	.	.	PROPN
admet-1513	1390	46	thompson	thompson	PROPN
admet-1513	1390	47	,	,	PUNCT
admet-1513	1390	48	a.	a.	NOUN
admet-1513	1390	49	asai	asai	PROPN
admet-1513	1390	50	,	,	PUNCT
admet-1513	1390	51	t.	t.	NOUN
admet-1513	1390	52	takebe	takebe	NOUN
admet-1513	1390	53	.	.	PUNCT
admet-1513	1391	1	high	high	ADJ
admet-1513	1391	2	-	-	PUNCT
admet-1513	1391	3	fidelity	fidelity	NOUN
admet-1513	1391	4	drug	drug	NOUN
admet-1513	1391	5	-	-	PUNCT
admet-1513	1391	6	induced	induce	VERB
admet-1513	1391	7	liver	liver	NOUN
admet-1513	1391	8	injury	injury	NOUN
admet-1513	1391	9	screen	screen	NOUN
admet-1513	1391	10	using	use	VERB
admet-1513	1391	11	human	human	ADJ
admet-1513	1391	12	pluripotent	pluripotent	NOUN
admet-1513	1391	13	stem	stem	NOUN
admet-1513	1391	14	cell	cell	NOUN
admet-1513	1391	15	-	-	PUNCT
admet-1513	1391	16	derived	derive	VERB
admet-1513	1391	17	organoids	organoid	NOUN
admet-1513	1391	18	.	.	PUNCT
admet-1513	1392	1	gastroenterology	gastroenterology	NOUN
admet-1513	1392	2	160	160	NUM
admet-1513	1392	3	(	(	PUNCT
admet-1513	1392	4	2021	2021	NUM
admet-1513	1392	5	)	)	PUNCT
admet-1513	1392	6	831	831	NUM
admet-1513	1392	7	-	-	PUNCT
admet-1513	1392	8	846.e10	846.e10	NUM
admet-1513	1392	9	.	.	PUNCT
admet-1513	1392	10	https://doi.org/10.1053/j.gastro.2020.10.002	https://doi.org/10.1053/j.gastro.2020.10.002	NOUN
admet-1513	1392	11	.	.	PUNCT
admet-1513	1393	1	[	[	X
admet-1513	1393	2	170	170	NUM
admet-1513	1393	3	]	]	PUNCT
admet-1513	1393	4	t.	t.	NOUN
admet-1513	1393	5	matsui	matsui	NOUN
admet-1513	1393	6	,	,	PUNCT
admet-1513	1393	7	t.	t.	PROPN
admet-1513	1393	8	shinozawa	shinozawa	PROPN
admet-1513	1393	9	.	.	PUNCT
admet-1513	1394	1	human	human	ADJ
admet-1513	1394	2	organoids	organoid	NOUN
admet-1513	1394	3	for	for	ADP
admet-1513	1394	4	predictive	predictive	ADJ
admet-1513	1394	5	toxicology	toxicology	NOUN
admet-1513	1394	6	research	research	NOUN
admet-1513	1394	7	and	and	CCONJ
admet-1513	1394	8	drug	drug	NOUN
admet-1513	1394	9	development	development	NOUN
admet-1513	1394	10	.	.	PUNCT
admet-1513	1395	1	front	front	ADJ
admet-1513	1395	2	.	.	PUNCT
admet-1513	1396	1	genet	genet	NOUN
admet-1513	1396	2	.	.	PUNCT
admet-1513	1397	1	12	12	NUM
admet-1513	1397	2	(	(	PUNCT
admet-1513	1397	3	2021	2021	NUM
admet-1513	1397	4	)	)	PUNCT
admet-1513	1397	5	767621	767621	NUM
admet-1513	1397	6	.	.	PUNCT
admet-1513	1398	1	https://doi.org/10.3389/fgene.2021.767621	https://doi.org/10.3389/fgene.2021.767621	PROPN
admet-1513	1398	2	.	.	PUNCT
admet-1513	1399	1	https://doi.org/10.1002/adbi.202100775	https://doi.org/10.1002/adbi.202100775	PROPN
admet-1513	1399	2	https://doi.org/10.2217/rme-2016-0152	https://doi.org/10.2217/rme-2016-0152	PROPN
admet-1513	1399	3	https://doi.org/10.1073/pnas.1522556113	https://doi.org/10.1073/pnas.1522556113	ADJ
admet-1513	1399	4	https://doi.org/10.1073/pnas.1522556113	https://doi.org/10.1073/pnas.1522556113	NOUN
admet-1513	1399	5	https://doi.org/10.1126/scitranslmed.aax5516	https://doi.org/10.1126/scitranslmed.aax5516	ADJ
admet-1513	1399	6	https://doi.org/10.1126/scitranslmed.aax5516	https://doi.org/10.1126/scitranslmed.aax5516	ADJ
admet-1513	1399	7	https://doi.org/10.1039/c8lc00869h	https://doi.org/10.1039/c8lc00869h	NOUN
admet-1513	1399	8	https://doi.org/10.1056/nejmra1816149	https://doi.org/10.1056/nejmra1816149	NOUN
admet-1513	1399	9	https://doi.org/10.1038/nrd4309	https://doi.org/10.1038/nrd4309	NOUN
admet-1513	1399	10	https://doi.org/10.1006/rtph.2000.1399	https://doi.org/10.1006/rtph.2000.1399	PROPN
admet-1513	1399	11	https://doi.org/10.1038/s41580-020-0259-3	https://doi.org/10.1038/s41580-020-0259-3	NUM
admet-1513	1399	12	https://doi.org/10.1089/scd.2017.0023	https://doi.org/10.1089/scd.2017.0023	PROPN
admet-1513	1399	13	https://doi.org/10.3389/fpubh.2018.00103	https://doi.org/10.3389/fpubh.2018.00103	PROPN
admet-1513	1399	14	https://doi.org/10.3390/ijms21082982	https://doi.org/10.3390/ijms21082982	NOUN
admet-1513	1399	15	https://doi.org/10.1053/j.gastro.2020.10.002	https://doi.org/10.1053/j.gastro.2020.10.002	NOUN
admet-1513	1399	16	https://doi.org/10.1053/j.gastro.2020.10.002	https://doi.org/10.1053/j.gastro.2020.10.002	NOUN
admet-1513	1399	17	https://doi.org/10.3389/fgene.2021.767621	https://doi.org/10.3389/fgene.2021.767621	PROPN
admet-1513	1399	18	admet	admet	PROPN
admet-1513	1399	19	&	&	CCONJ
admet-1513	1399	20	dmpk	dmpk	PROPN
admet-1513	1399	21	11(1	11(1	NUM
admet-1513	1399	22	)	)	PUNCT
admet-1513	1399	23	(	(	PUNCT
admet-1513	1399	24	2023	2023	NUM
admet-1513	1399	25	)	)	PUNCT
admet-1513	1399	26	1	1	NUM
admet-1513	1399	27	-	-	SYM
admet-1513	1399	28	32	32	NUM
admet-1513	1399	29	2d	2d	NOUN
admet-1513	1399	30	and	and	CCONJ
admet-1513	1399	31	3d	3d	NOUN
admet-1513	1399	32	adme	adme	PROPN
admet-1513	1399	33	-	-	PUNCT
admet-1513	1399	34	tox	tox	NOUN
admet-1513	1399	35	cell	cell	NOUN
admet-1513	1399	36	culture	culture	NOUN
admet-1513	1399	37	screening	screen	VERB
admet-1513	1399	38	:	:	PUNCT
admet-1513	1399	39	a	a	DET
admet-1513	1399	40	review	review	NOUN
admet-1513	1399	41	doi	doi	NOUN
admet-1513	1399	42	:	:	PUNCT
admet-1513	1399	43	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	1399	44	29	29	NUM
admet-1513	1400	1	[	[	X
admet-1513	1400	2	171	171	NUM
admet-1513	1400	3	]	]	X
admet-1513	1400	4	d.m	d.m	PROPN
admet-1513	1400	5	.	.	PUNCT
admet-1513	1400	6	roden	roden	PROPN
admet-1513	1400	7	.	.	PUNCT
admet-1513	1401	1	predicting	predict	VERB
admet-1513	1401	2	drug	drug	NOUN
admet-1513	1401	3	-	-	PUNCT
admet-1513	1401	4	induced	induce	VERB
admet-1513	1401	5	qt	qt	NOUN
admet-1513	1401	6	prolongation	prolongation	NOUN
admet-1513	1401	7	and	and	CCONJ
admet-1513	1401	8	torsades	torsade	NOUN
admet-1513	1401	9	de	de	ADP
admet-1513	1401	10	pointes	pointe	NOUN
admet-1513	1401	11	.	.	PUNCT
admet-1513	1402	1	j.	j.	PROPN
admet-1513	1402	2	physiol	physiol	PROPN
admet-1513	1402	3	.	.	PUNCT
admet-1513	1403	1	594	594	NUM
admet-1513	1403	2	(	(	PUNCT
admet-1513	1403	3	2016	2016	NUM
admet-1513	1403	4	)	)	PUNCT
admet-1513	1403	5	2459	2459	NUM
admet-1513	1403	6	-	-	SYM
admet-1513	1403	7	2468	2468	NUM
admet-1513	1403	8	.	.	PUNCT
admet-1513	1404	1	https://doi.org/10.1113/jp270526	https://doi.org/10.1113/jp270526	PROPN
admet-1513	1404	2	.	.	PUNCT
admet-1513	1405	1	[	[	X
admet-1513	1405	2	172	172	NUM
admet-1513	1405	3	]	]	X
admet-1513	1405	4	j.v	j.v	PROPN
admet-1513	1405	5	.	.	PUNCT
admet-1513	1405	6	mcgowan	mcgowan	PROPN
admet-1513	1405	7	,	,	PUNCT
admet-1513	1405	8	r.	r.	PROPN
admet-1513	1405	9	chung	chung	PROPN
admet-1513	1405	10	,	,	PUNCT
admet-1513	1405	11	a.	a.	NOUN
admet-1513	1405	12	maulik	maulik	PROPN
admet-1513	1405	13	,	,	PUNCT
admet-1513	1405	14	i.	i.	PROPN
admet-1513	1405	15	piotrowska	piotrowska	PROPN
admet-1513	1405	16	,	,	PUNCT
admet-1513	1405	17	j.m	j.m	PROPN
admet-1513	1405	18	.	.	PROPN
admet-1513	1405	19	walker	walker	PROPN
admet-1513	1405	20	,	,	PUNCT
admet-1513	1405	21	d.m	d.m	PROPN
admet-1513	1405	22	.	.	PROPN
admet-1513	1405	23	yellon	yellon	PROPN
admet-1513	1405	24	.	.	PUNCT
admet-1513	1406	1	anthracycline	anthracycline	PROPN
admet-1513	1406	2	chemotherapy	chemotherapy	NOUN
admet-1513	1406	3	and	and	CCONJ
admet-1513	1406	4	cardiotoxicity	cardiotoxicity	PROPN
admet-1513	1406	5	.	.	PUNCT
admet-1513	1407	1	cardiovasc	cardiovasc	PROPN
admet-1513	1407	2	.	.	PUNCT
admet-1513	1408	1	drugs	drug	NOUN
admet-1513	1408	2	ther	ther	ADV
admet-1513	1408	3	.	.	PUNCT
admet-1513	1409	1	31	31	NUM
admet-1513	1409	2	(	(	PUNCT
admet-1513	1409	3	2017	2017	NUM
admet-1513	1409	4	)	)	PUNCT
admet-1513	1409	5	63	63	NUM
admet-1513	1409	6	-	-	SYM
admet-1513	1409	7	75	75	NUM
admet-1513	1409	8	.	.	PUNCT
admet-1513	1410	1	https://doi.org/10.1007/s10557-016-6711-0	https://doi.org/10.1007/s10557-016-6711-0	NUM
admet-1513	1410	2	.	.	PUNCT
admet-1513	1411	1	[	[	X
admet-1513	1411	2	173	173	NUM
admet-1513	1411	3	]	]	X
admet-1513	1411	4	m.r	m.r	PROPN
admet-1513	1411	5	.	.	PROPN
admet-1513	1411	6	bowlby	bowlby	PROPN
admet-1513	1411	7	,	,	PUNCT
admet-1513	1411	8	r.	r.	PROPN
admet-1513	1411	9	peri	peri	PROPN
admet-1513	1411	10	,	,	PUNCT
admet-1513	1411	11	h.	h.	PROPN
admet-1513	1411	12	zhang	zhang	PROPN
admet-1513	1411	13	,	,	PUNCT
admet-1513	1411	14	j.	j.	PROPN
admet-1513	1411	15	dunlop	dunlop	PROPN
admet-1513	1411	16	.	.	PUNCT
admet-1513	1412	1	herg	herg	PROPN
admet-1513	1412	2	(	(	PUNCT
admet-1513	1412	3	kcnh2	kcnh2	NOUN
admet-1513	1412	4	or	or	CCONJ
admet-1513	1412	5	kv11.1	kv11.1	PROPN
admet-1513	1412	6	)	)	PUNCT
admet-1513	1412	7	k+	k+	NOUN
admet-1513	1412	8	channels	channel	NOUN
admet-1513	1412	9	:	:	PUNCT
admet-1513	1412	10	screening	screen	VERB
admet-1513	1412	11	for	for	ADP
admet-1513	1412	12	cardiac	cardiac	ADJ
admet-1513	1412	13	arrhythmia	arrhythmia	NOUN
admet-1513	1412	14	risk	risk	NOUN
admet-1513	1412	15	.	.	PUNCT
admet-1513	1413	1	curr	curr	PROPN
admet-1513	1413	2	.	.	PUNCT
admet-1513	1413	3	drug	drug	PROPN
admet-1513	1413	4	metab	metab	NOUN
admet-1513	1413	5	.	.	PUNCT
admet-1513	1414	1	9	9	NUM
admet-1513	1414	2	(	(	PUNCT
admet-1513	1414	3	2008	2008	NUM
admet-1513	1414	4	)	)	PUNCT
admet-1513	1414	5	965	965	NUM
admet-1513	1414	6	-	-	SYM
admet-1513	1414	7	970	970	NUM
admet-1513	1414	8	.	.	PUNCT
admet-1513	1415	1	https://doi.org/10.2174/138920008786485083	https://doi.org/10.2174/138920008786485083	X
admet-1513	1415	2	.	.	PUNCT
admet-1513	1416	1	[	[	X
admet-1513	1416	2	174	174	NUM
admet-1513	1416	3	]	]	PUNCT
admet-1513	1416	4	h.	h.	PROPN
admet-1513	1416	5	ando	ando	PROPN
admet-1513	1416	6	,	,	PUNCT
admet-1513	1416	7	t.	t.	PROPN
admet-1513	1416	8	yoshinaga	yoshinaga	PROPN
admet-1513	1416	9	,	,	PUNCT
admet-1513	1416	10	w.	w.	PROPN
admet-1513	1416	11	yamamoto	yamamoto	PROPN
admet-1513	1416	12	,	,	PUNCT
admet-1513	1416	13	k.	k.	PROPN
admet-1513	1416	14	asakura	asakura	PROPN
admet-1513	1416	15	,	,	PUNCT
admet-1513	1416	16	t.	t.	NOUN
admet-1513	1416	17	uda	uda	NOUN
admet-1513	1416	18	,	,	PUNCT
admet-1513	1416	19	t.	t.	PROPN
admet-1513	1416	20	taniguchi	taniguchi	PROPN
admet-1513	1416	21	,	,	PUNCT
admet-1513	1416	22	a.	a.	PROPN
admet-1513	1416	23	ojima	ojima	PROPN
admet-1513	1416	24	,	,	PUNCT
admet-1513	1416	25	r.	r.	PROPN
admet-1513	1416	26	shinkyo	shinkyo	PROPN
admet-1513	1416	27	,	,	PUNCT
admet-1513	1416	28	k.	k.	PROPN
admet-1513	1416	29	kikuchi	kikuchi	PROPN
admet-1513	1416	30	,	,	PUNCT
admet-1513	1416	31	t.	t.	PROPN
admet-1513	1416	32	osada	osada	PROPN
admet-1513	1416	33	,	,	PUNCT
admet-1513	1416	34	s.	s.	PROPN
admet-1513	1416	35	hayashi	hayashi	PROPN
admet-1513	1416	36	,	,	PUNCT
admet-1513	1416	37	c.	c.	PROPN
admet-1513	1416	38	kasai	kasai	PROPN
admet-1513	1416	39	,	,	PUNCT
admet-1513	1416	40	n.	n.	PROPN
admet-1513	1416	41	miyamoto	miyamoto	PROPN
admet-1513	1416	42	,	,	PUNCT
admet-1513	1416	43	h.	h.	PROPN
admet-1513	1416	44	tashibu	tashibu	NOUN
admet-1513	1416	45	,	,	PUNCT
admet-1513	1416	46	d.	d.	PROPN
admet-1513	1416	47	yamazaki	yamazaki	PROPN
admet-1513	1416	48	,	,	PUNCT
admet-1513	1416	49	a.	a.	NOUN
admet-1513	1416	50	sugiyama	sugiyama	PROPN
admet-1513	1416	51	,	,	PUNCT
admet-1513	1416	52	y.	y.	PROPN
admet-1513	1416	53	kanda	kanda	PROPN
admet-1513	1416	54	,	,	PUNCT
admet-1513	1416	55	k.	k.	PROPN
admet-1513	1416	56	sawada	sawada	PROPN
admet-1513	1416	57	,	,	PUNCT
admet-1513	1416	58	y.	y.	PROPN
admet-1513	1416	59	sekino	sekino	PROPN
admet-1513	1416	60	.	.	PUNCT
admet-1513	1417	1	a	a	DET
admet-1513	1417	2	new	new	ADJ
admet-1513	1417	3	paradigm	paradigm	NOUN
admet-1513	1417	4	for	for	ADP
admet-1513	1417	5	drug	drug	NOUN
admet-1513	1417	6	-	-	PUNCT
admet-1513	1417	7	induced	induce	VERB
admet-1513	1417	8	torsadogenic	torsadogenic	ADJ
admet-1513	1417	9	risk	risk	NOUN
admet-1513	1417	10	assessment	assessment	NOUN
admet-1513	1417	11	using	use	VERB
admet-1513	1417	12	human	human	ADJ
admet-1513	1417	13	ips	ip	NOUN
admet-1513	1417	14	cell	cell	NOUN
admet-1513	1417	15	-	-	PUNCT
admet-1513	1417	16	derived	derive	VERB
admet-1513	1417	17	cardiomyocytes	cardiomyocyte	NOUN
admet-1513	1417	18	.	.	PUNCT
admet-1513	1418	1	j.	j.	PROPN
admet-1513	1418	2	pharmacol	pharmacol	PROPN
admet-1513	1418	3	.	.	PUNCT
admet-1513	1419	1	toxicol	toxicol	PROPN
admet-1513	1419	2	.	.	PUNCT
admet-1513	1420	1	methods	method	NOUN
admet-1513	1420	2	84	84	NUM
admet-1513	1420	3	(	(	PUNCT
admet-1513	1420	4	2017	2017	NUM
admet-1513	1420	5	)	)	PUNCT
admet-1513	1420	6	111	111	NUM
admet-1513	1420	7	-	-	SYM
admet-1513	1420	8	127	127	NUM
admet-1513	1420	9	.	.	PUNCT
admet-1513	1421	1	https://doi.org/10.1016/j.vascn.2016.12.003	https://doi.org/10.1016/j.vascn.2016.12.003	NOUN
admet-1513	1421	2	.	.	PUNCT
admet-1513	1422	1	[	[	X
admet-1513	1422	2	175	175	NUM
admet-1513	1422	3	]	]	X
admet-1513	1422	4	d.	d.	PROPN
admet-1513	1422	5	yamazaki	yamazaki	PROPN
admet-1513	1422	6	,	,	PUNCT
admet-1513	1422	7	t.	t.	PROPN
admet-1513	1422	8	kitaguchi	kitaguchi	PROPN
admet-1513	1422	9	,	,	PUNCT
admet-1513	1422	10	m.	m.	NOUN
admet-1513	1422	11	ishimura	ishimura	PROPN
admet-1513	1422	12	,	,	PUNCT
admet-1513	1422	13	t.	t.	PROPN
admet-1513	1422	14	taniguchi	taniguchi	PROPN
admet-1513	1422	15	,	,	PUNCT
admet-1513	1422	16	a.	a.	PROPN
admet-1513	1422	17	yamanishi	yamanishi	PROPN
admet-1513	1422	18	,	,	PUNCT
admet-1513	1422	19	d.	d.	PROPN
admet-1513	1422	20	saji	saji	PROPN
admet-1513	1422	21	,	,	PUNCT
admet-1513	1422	22	e.	e.	PROPN
admet-1513	1422	23	takahashi	takahashi	PROPN
admet-1513	1422	24	,	,	PUNCT
admet-1513	1422	25	m.	m.	NOUN
admet-1513	1422	26	oguchi	oguchi	PROPN
admet-1513	1422	27	,	,	PUNCT
admet-1513	1422	28	y.	y.	PROPN
admet-1513	1422	29	moriyama	moriyama	PROPN
admet-1513	1422	30	,	,	PUNCT
admet-1513	1422	31	s.	s.	PROPN
admet-1513	1422	32	maeda	maeda	PROPN
admet-1513	1422	33	,	,	PUNCT
admet-1513	1422	34	k.	k.	PROPN
admet-1513	1422	35	miyamoto	miyamoto	PROPN
admet-1513	1422	36	,	,	PUNCT
admet-1513	1422	37	k.	k.	PROPN
admet-1513	1422	38	morimura	morimura	PROPN
admet-1513	1422	39	,	,	PUNCT
admet-1513	1422	40	h.	h.	PROPN
admet-1513	1422	41	ohnaka	ohnaka	PROPN
admet-1513	1422	42	,	,	PUNCT
admet-1513	1422	43	h.	h.	PROPN
admet-1513	1422	44	tashibu	tashibu	NOUN
admet-1513	1422	45	,	,	PUNCT
admet-1513	1422	46	y.	y.	PROPN
admet-1513	1422	47	sekino	sekino	PROPN
admet-1513	1422	48	,	,	PUNCT
admet-1513	1422	49	n.	n.	PROPN
admet-1513	1422	50	miyamoto	miyamoto	NOUN
admet-1513	1422	51	,	,	PUNCT
admet-1513	1422	52	y.	y.	PROPN
admet-1513	1422	53	kanda	kanda	PROPN
admet-1513	1422	54	.	.	PUNCT
admet-1513	1423	1	proarrhythmia	proarrhythmia	PROPN
admet-1513	1423	2	risk	risk	NOUN
admet-1513	1423	3	prediction	prediction	NOUN
admet-1513	1423	4	using	use	VERB
admet-1513	1423	5	human	human	ADJ
admet-1513	1423	6	induced	induced	ADJ
admet-1513	1423	7	pluripotent	pluripotent	NOUN
admet-1513	1423	8	stem	stem	NOUN
admet-1513	1423	9	cell	cell	NOUN
admet-1513	1423	10	-	-	PUNCT
admet-1513	1423	11	derived	derive	VERB
admet-1513	1423	12	cardiomyocytes	cardiomyocyte	NOUN
admet-1513	1423	13	.	.	PUNCT
admet-1513	1424	1	j.	j.	PROPN
admet-1513	1424	2	pharmacol	pharmacol	PROPN
admet-1513	1424	3	.	.	PUNCT
admet-1513	1425	1	sci	sci	PROPN
admet-1513	1425	2	.	.	PROPN
admet-1513	1426	1	136	136	NUM
admet-1513	1426	2	(	(	PUNCT
admet-1513	1426	3	2018	2018	NUM
admet-1513	1426	4	)	)	PUNCT
admet-1513	1426	5	249	249	NUM
admet-1513	1426	6	-	-	SYM
admet-1513	1426	7	256	256	NUM
admet-1513	1426	8	.	.	PUNCT
admet-1513	1427	1	https://doi.org/10.1016/j.jphs.2018.02.005	https://doi.org/10.1016/j.jphs.2018.02.005	NOUN
admet-1513	1427	2	.	.	PUNCT
admet-1513	1428	1	[	[	X
admet-1513	1428	2	176	176	X
admet-1513	1428	3	]	]	X
admet-1513	1428	4	o.	o.	PROPN
admet-1513	1428	5	scheel	scheel	PROPN
admet-1513	1428	6	,	,	PUNCT
admet-1513	1428	7	s.	s.	PROPN
admet-1513	1428	8	frech	frech	PROPN
admet-1513	1428	9	,	,	PUNCT
admet-1513	1428	10	b.	b.	PROPN
admet-1513	1428	11	amuzescu	amuzescu	PROPN
admet-1513	1428	12	,	,	PUNCT
admet-1513	1428	13	j.	j.	PROPN
admet-1513	1428	14	eisfeld	eisfeld	PROPN
admet-1513	1428	15	,	,	PUNCT
admet-1513	1428	16	k.h	k.h	PROPN
admet-1513	1428	17	.	.	PROPN
admet-1513	1428	18	lin	lin	PROPN
admet-1513	1428	19	,	,	PUNCT
admet-1513	1428	20	t.	t.	PROPN
admet-1513	1428	21	knott	knott	PROPN
admet-1513	1428	22	.	.	PUNCT
admet-1513	1429	1	action	action	NOUN
admet-1513	1429	2	potential	potential	ADJ
admet-1513	1429	3	characterization	characterization	NOUN
admet-1513	1429	4	of	of	ADP
admet-1513	1429	5	human	human	ADJ
admet-1513	1429	6	induced	induced	ADJ
admet-1513	1429	7	pluripotent	pluripotent	NOUN
admet-1513	1429	8	stem	stem	NOUN
admet-1513	1429	9	cell	cell	NOUN
admet-1513	1429	10	-	-	PUNCT
admet-1513	1429	11	derived	derive	VERB
admet-1513	1429	12	cardiomyocytes	cardiomyocyte	NOUN
admet-1513	1429	13	using	use	VERB
admet-1513	1429	14	automated	automate	VERB
admet-1513	1429	15	patch	patch	ADJ
admet-1513	1429	16	-	-	PUNCT
admet-1513	1429	17	clamp	clamp	NOUN
admet-1513	1429	18	technology	technology	NOUN
admet-1513	1429	19	.	.	PUNCT
admet-1513	1430	1	assay	assay	PROPN
admet-1513	1430	2	drug	drug	PROPN
admet-1513	1430	3	dev	dev	PROPN
admet-1513	1430	4	.	.	PUNCT
admet-1513	1431	1	technol	technol	PROPN
admet-1513	1431	2	.	.	PROPN
admet-1513	1432	1	12	12	NUM
admet-1513	1432	2	(	(	PUNCT
admet-1513	1432	3	2014	2014	NUM
admet-1513	1432	4	)	)	PUNCT
admet-1513	1432	5	457	457	NUM
admet-1513	1432	6	-	-	SYM
admet-1513	1432	7	469	469	NUM
admet-1513	1432	8	.	.	PUNCT
admet-1513	1432	9	https://doi.org/10.1089/adt.2014.601	https://doi.org/10.1089/adt.2014.601	NOUN
admet-1513	1432	10	.	.	PUNCT
admet-1513	1433	1	[	[	X
admet-1513	1433	2	177	177	NUM
admet-1513	1433	3	]	]	X
admet-1513	1433	4	e.r	e.r	PROPN
admet-1513	1433	5	.	.	PROPN
admet-1513	1433	6	pfeiffer	pfeiffer	PROPN
admet-1513	1433	7	,	,	PUNCT
admet-1513	1433	8	r.	r.	PROPN
admet-1513	1433	9	vega	vega	PROPN
admet-1513	1433	10	,	,	PUNCT
admet-1513	1433	11	p.m.	p.m.	PROPN
admet-1513	1433	12	mcdonough	mcdonough	PROPN
admet-1513	1433	13	,	,	PUNCT
admet-1513	1433	14	j.h	j.h	PROPN
admet-1513	1433	15	.	.	PROPN
admet-1513	1433	16	price	price	PROPN
admet-1513	1433	17	,	,	PUNCT
admet-1513	1433	18	r.	r.	PROPN
admet-1513	1433	19	whittaker	whittaker	PROPN
admet-1513	1433	20	.	.	PUNCT
admet-1513	1434	1	specific	specific	ADJ
admet-1513	1434	2	prediction	prediction	NOUN
admet-1513	1434	3	of	of	ADP
admet-1513	1434	4	clinical	clinical	ADJ
admet-1513	1434	5	qt	qt	NOUN
admet-1513	1434	6	prolongation	prolongation	NOUN
admet-1513	1434	7	by	by	ADP
admet-1513	1434	8	kinetic	kinetic	ADJ
admet-1513	1434	9	image	image	NOUN
admet-1513	1434	10	cytometry	cytometry	NOUN
admet-1513	1434	11	in	in	ADP
admet-1513	1434	12	human	human	ADJ
admet-1513	1434	13	stem	stem	NOUN
admet-1513	1434	14	cell	cell	NOUN
admet-1513	1434	15	derived	derive	VERB
admet-1513	1434	16	cardiomyocytes	cardiomyocyte	NOUN
admet-1513	1434	17	.	.	PUNCT
admet-1513	1435	1	j	j	PROPN
admet-1513	1435	2	pharmacol	pharmacol	PROPN
admet-1513	1435	3	.	.	PUNCT
admet-1513	1436	1	toxicol	toxicol	PROPN
admet-1513	1436	2	.	.	PUNCT
admet-1513	1437	1	methods	method	NOUN
admet-1513	1437	2	81	81	NUM
admet-1513	1437	3	(	(	PUNCT
admet-1513	1437	4	2016	2016	NUM
admet-1513	1437	5	)	)	PUNCT
admet-1513	1437	6	263	263	NUM
admet-1513	1437	7	-	-	SYM
admet-1513	1437	8	273	273	NUM
admet-1513	1437	9	.	.	PUNCT
admet-1513	1438	1	https://doi.org/10.1016/j.vascn.2016.04.007	https://doi.org/10.1016/j.vascn.2016.04.007	VERB
admet-1513	1438	2	.	.	PUNCT
admet-1513	1439	1	[	[	X
admet-1513	1439	2	178	178	NUM
admet-1513	1439	3	]	]	X
admet-1513	1439	4	n.m	n.m	PROPN
admet-1513	1439	5	.	.	PROPN
admet-1513	1439	6	patel	patel	PROPN
admet-1513	1439	7	,	,	PUNCT
admet-1513	1439	8	m.a	m.a	PROPN
admet-1513	1439	9	.	.	PROPN
admet-1513	1439	10	mohamed	mohamed	PROPN
admet-1513	1439	11	,	,	PUNCT
admet-1513	1439	12	i.k	i.k	PROPN
admet-1513	1439	13	.	.	PROPN
admet-1513	1439	14	yazdi	yazdi	PROPN
admet-1513	1439	15	,	,	PUNCT
admet-1513	1439	16	e.	e.	PROPN
admet-1513	1439	17	tasciotti	tasciotti	PROPN
admet-1513	1439	18	,	,	PUNCT
admet-1513	1439	19	r.k	r.k	PROPN
admet-1513	1439	20	.	.	PROPN
admet-1513	1439	21	birla	birla	PROPN
admet-1513	1439	22	.	.	PUNCT
admet-1513	1440	1	the	the	DET
admet-1513	1440	2	design	design	NOUN
admet-1513	1440	3	and	and	CCONJ
admet-1513	1440	4	fabrication	fabrication	NOUN
admet-1513	1440	5	of	of	ADP
admet-1513	1440	6	a	a	DET
admet-1513	1440	7	threedimensional	threedimensional	NOUN
admet-1513	1440	8	bioengineered	bioengineere	VERB
admet-1513	1440	9	open	open	ADJ
admet-1513	1440	10	ventricle	ventricle	NOUN
admet-1513	1440	11	.	.	PUNCT
admet-1513	1441	1	j.	j.	PROPN
admet-1513	1441	2	biomed	biome	VERB
admet-1513	1441	3	.	.	PUNCT
admet-1513	1442	1	mater	mater	NOUN
admet-1513	1442	2	.	.	PUNCT
admet-1513	1443	1	res	re	NOUN
admet-1513	1443	2	.	.	PUNCT
admet-1513	1444	1	b	b	X
admet-1513	1444	2	appl	appl	PROPN
admet-1513	1444	3	.	.	PUNCT
admet-1513	1445	1	biomater	biomater	NOUN
admet-1513	1445	2	.	.	PUNCT
admet-1513	1446	1	105	105	NUM
admet-1513	1446	2	(	(	PUNCT
admet-1513	1446	3	2017	2017	NUM
admet-1513	1446	4	)	)	PUNCT
admet-1513	1446	5	22062217	22062217	NUM
admet-1513	1446	6	.	.	PUNCT
admet-1513	1447	1	https://doi.org/10.1002/jbm.b.33742	https://doi.org/10.1002/jbm.b.33742	X
admet-1513	1447	2	.	.	PUNCT
admet-1513	1448	1	[	[	X
admet-1513	1448	2	179	179	NUM
admet-1513	1448	3	]	]	X
admet-1513	1448	4	m.l	m.l	PROPN
admet-1513	1448	5	.	.	PROPN
admet-1513	1448	6	schulze	schulze	PROPN
admet-1513	1448	7	,	,	PUNCT
admet-1513	1448	8	m.d	m.d	PROPN
admet-1513	1448	9	.	.	PROPN
admet-1513	1448	10	lemoine	lemoine	PROPN
admet-1513	1448	11	,	,	PUNCT
admet-1513	1448	12	a.w	a.w	PROPN
admet-1513	1448	13	.	.	PROPN
admet-1513	1448	14	fischer	fischer	PROPN
admet-1513	1448	15	,	,	PUNCT
admet-1513	1448	16	k.	k.	PROPN
admet-1513	1448	17	scherschel	scherschel	PROPN
admet-1513	1448	18	,	,	PUNCT
admet-1513	1448	19	r.	r.	PROPN
admet-1513	1448	20	david	david	PROPN
admet-1513	1448	21	,	,	PUNCT
admet-1513	1448	22	k.	k.	PROPN
admet-1513	1448	23	riecken	riecken	PROPN
admet-1513	1448	24	,	,	PUNCT
admet-1513	1448	25	a.	a.	PROPN
admet-1513	1448	26	hansen	hansen	PROPN
admet-1513	1448	27	,	,	PUNCT
admet-1513	1448	28	t.	t.	PROPN
admet-1513	1448	29	eschenhagen	eschenhagen	PROPN
admet-1513	1448	30	,	,	PUNCT
admet-1513	1448	31	b.m	b.m	PROPN
admet-1513	1448	32	.	.	PROPN
admet-1513	1448	33	ulmer	ulmer	PROPN
admet-1513	1448	34	.	.	PUNCT
admet-1513	1449	1	dissecting	dissect	VERB
admet-1513	1449	2	hipsc	hipsc	ADJ
admet-1513	1449	3	-	-	PUNCT
admet-1513	1449	4	cm	cm	NOUN
admet-1513	1449	5	pacemaker	pacemaker	NOUN
admet-1513	1449	6	function	function	NOUN
admet-1513	1449	7	in	in	ADP
admet-1513	1449	8	a	a	DET
admet-1513	1449	9	cardiac	cardiac	ADJ
admet-1513	1449	10	organoid	organoid	NOUN
admet-1513	1449	11	model	model	NOUN
admet-1513	1449	12	.	.	PUNCT
admet-1513	1450	1	biomaterials	biomaterial	NOUN
admet-1513	1450	2	206	206	NUM
admet-1513	1450	3	(	(	PUNCT
admet-1513	1450	4	2019	2019	NUM
admet-1513	1450	5	)	)	PUNCT
admet-1513	1450	6	133	133	NUM
admet-1513	1450	7	-	-	SYM
admet-1513	1450	8	145	145	NUM
admet-1513	1450	9	.	.	PUNCT
admet-1513	1451	1	https://doi.org/10.1016/j.biomaterials.2019.03.023	https://doi.org/10.1016/j.biomaterials.2019.03.023	PROPN
admet-1513	1451	2	.	.	PUNCT
admet-1513	1452	1	[	[	X
admet-1513	1452	2	180	180	NUM
admet-1513	1452	3	]	]	X
admet-1513	1452	4	r.j	r.j	PROPN
admet-1513	1452	5	.	.	PROPN
admet-1513	1452	6	mills	mills	PROPN
admet-1513	1452	7	,	,	PUNCT
admet-1513	1452	8	b.l	b.l	PROPN
admet-1513	1452	9	.	.	PROPN
admet-1513	1452	10	parker	parker	PROPN
admet-1513	1452	11	,	,	PUNCT
admet-1513	1452	12	g.a	g.a	PROPN
admet-1513	1452	13	.	.	PROPN
admet-1513	1452	14	quaife	quaife	PROPN
admet-1513	1452	15	-	-	PUNCT
admet-1513	1452	16	ryan	ryan	PROPN
admet-1513	1452	17	,	,	PUNCT
admet-1513	1452	18	h.k	h.k	PROPN
admet-1513	1452	19	.	.	PROPN
admet-1513	1452	20	voges	voges	PROPN
admet-1513	1452	21	,	,	PUNCT
admet-1513	1452	22	e.j	e.j	PROPN
admet-1513	1452	23	.	.	PROPN
admet-1513	1452	24	needham	needham	PROPN
admet-1513	1452	25	,	,	PUNCT
admet-1513	1452	26	a.	a.	NOUN
admet-1513	1452	27	bornot	bornot	PROPN
admet-1513	1452	28	,	,	PUNCT
admet-1513	1452	29	m.	m.	NOUN
admet-1513	1452	30	ding	ding	PROPN
admet-1513	1452	31	,	,	PUNCT
admet-1513	1452	32	h.	h.	PROPN
admet-1513	1452	33	andersson	andersson	PROPN
admet-1513	1452	34	,	,	PUNCT
admet-1513	1452	35	m.	m.	NOUN
admet-1513	1452	36	polla	polla	PROPN
admet-1513	1452	37	,	,	PUNCT
admet-1513	1452	38	d.a	d.a	PROPN
admet-1513	1452	39	.	.	PROPN
admet-1513	1452	40	elliott	elliott	PROPN
admet-1513	1452	41	,	,	PUNCT
admet-1513	1452	42	l.	l.	PROPN
admet-1513	1452	43	drowley	drowley	PROPN
admet-1513	1452	44	,	,	PUNCT
admet-1513	1452	45	m.	m.	PROPN
admet-1513	1452	46	clausen	clausen	PROPN
admet-1513	1452	47	,	,	PUNCT
admet-1513	1452	48	a.t	a.t	PROPN
admet-1513	1452	49	.	.	PROPN
admet-1513	1452	50	plowright	plowright	PROPN
admet-1513	1452	51	,	,	PUNCT
admet-1513	1452	52	i.p	i.p	PROPN
admet-1513	1452	53	.	.	PROPN
admet-1513	1452	54	barrett	barrett	PROPN
admet-1513	1452	55	,	,	PUNCT
admet-1513	1452	56	q.d	q.d	PROPN
admet-1513	1452	57	.	.	PROPN
admet-1513	1452	58	wang	wang	PROPN
admet-1513	1452	59	,	,	PUNCT
admet-1513	1452	60	d.e	d.e	PROPN
admet-1513	1452	61	.	.	PROPN
admet-1513	1452	62	james	james	PROPN
admet-1513	1452	63	,	,	PUNCT
admet-1513	1452	64	e.r	e.r	PROPN
admet-1513	1452	65	.	.	PROPN
admet-1513	1452	66	porrello	porrello	PROPN
admet-1513	1452	67	,	,	PUNCT
admet-1513	1452	68	j.e	j.e	PROPN
admet-1513	1452	69	.	.	PROPN
admet-1513	1452	70	hudson	hudson	PROPN
admet-1513	1452	71	.	.	PUNCT
admet-1513	1453	1	drug	drug	NOUN
admet-1513	1453	2	screening	screening	NOUN
admet-1513	1453	3	in	in	ADP
admet-1513	1453	4	human	human	ADJ
admet-1513	1453	5	psc	psc	ADJ
admet-1513	1453	6	-	-	PUNCT
admet-1513	1453	7	cardiac	cardiac	ADJ
admet-1513	1453	8	organoids	organoid	NOUN
admet-1513	1453	9	identifies	identify	VERB
admet-1513	1453	10	pro	pro	ADJ
admet-1513	1453	11	-	-	ADJ
admet-1513	1453	12	proliferative	proliferative	ADJ
admet-1513	1453	13	compounds	compound	NOUN
admet-1513	1453	14	acting	act	VERB
admet-1513	1453	15	via	via	ADP
admet-1513	1453	16	the	the	DET
admet-1513	1453	17	mevalonate	mevalonate	ADJ
admet-1513	1453	18	pathway	pathway	NOUN
admet-1513	1453	19	.	.	PUNCT
admet-1513	1454	1	cell	cell	NOUN
admet-1513	1454	2	stem	stem	NOUN
admet-1513	1454	3	cell	cell	NOUN
admet-1513	1454	4	24	24	NUM
admet-1513	1454	5	(	(	PUNCT
admet-1513	1454	6	2019	2019	NUM
admet-1513	1454	7	)	)	PUNCT
admet-1513	1454	8	895	895	NUM
admet-1513	1454	9	-	-	PUNCT
admet-1513	1454	10	907.e6	907.e6	NUM
admet-1513	1454	11	.	.	PUNCT
admet-1513	1455	1	https://doi.org/10.1016/j.stem.2019.03.009	https://doi.org/10.1016/j.stem.2019.03.009	NUM
admet-1513	1455	2	.	.	PUNCT
admet-1513	1456	1	[	[	X
admet-1513	1456	2	181	181	NUM
admet-1513	1456	3	]	]	X
admet-1513	1456	4	d.j	d.j	PROPN
admet-1513	1456	5	.	.	PROPN
admet-1513	1456	6	richards	richards	PROPN
admet-1513	1456	7	,	,	PUNCT
admet-1513	1456	8	r.c	r.c	PROPN
admet-1513	1456	9	.	.	PROPN
admet-1513	1456	10	coyle	coyle	PROPN
admet-1513	1456	11	,	,	PUNCT
admet-1513	1456	12	y.	y.	PROPN
admet-1513	1456	13	tan	tan	PROPN
admet-1513	1456	14	,	,	PUNCT
admet-1513	1456	15	j.	j.	PROPN
admet-1513	1456	16	jia	jia	PROPN
admet-1513	1456	17	,	,	PUNCT
admet-1513	1456	18	k.	k.	PROPN
admet-1513	1456	19	wong	wong	PROPN
admet-1513	1456	20	,	,	PUNCT
admet-1513	1456	21	k.	k.	PROPN
admet-1513	1456	22	toomer	toomer	PROPN
admet-1513	1456	23	,	,	PUNCT
admet-1513	1456	24	d.r	d.r	PROPN
admet-1513	1456	25	.	.	PROPN
admet-1513	1456	26	menick	menick	PROPN
admet-1513	1456	27	,	,	PUNCT
admet-1513	1456	28	y.	y.	PROPN
admet-1513	1456	29	mei	mei	PROPN
admet-1513	1456	30	.	.	PUNCT
admet-1513	1456	31	inspiration	inspiration	NOUN
admet-1513	1456	32	from	from	ADP
admet-1513	1456	33	heart	heart	NOUN
admet-1513	1456	34	development	development	NOUN
admet-1513	1456	35	:	:	PUNCT
admet-1513	1456	36	biomimetic	biomimetic	ADJ
admet-1513	1456	37	development	development	NOUN
admet-1513	1456	38	of	of	ADP
admet-1513	1456	39	functional	functional	ADJ
admet-1513	1456	40	human	human	ADJ
admet-1513	1456	41	cardiac	cardiac	ADJ
admet-1513	1456	42	organoids	organoid	NOUN
admet-1513	1456	43	.	.	PUNCT
admet-1513	1457	1	biomaterials	biomaterial	NOUN
admet-1513	1457	2	142	142	NUM
admet-1513	1457	3	(	(	PUNCT
admet-1513	1457	4	2017	2017	NUM
admet-1513	1457	5	)	)	PUNCT
admet-1513	1457	6	112	112	NUM
admet-1513	1457	7	-	-	SYM
admet-1513	1457	8	123	123	NUM
admet-1513	1457	9	.	.	PUNCT
admet-1513	1458	1	https://doi.org/10.1016/j.biomaterials.2017.07.021	https://doi.org/10.1016/j.biomaterials.2017.07.021	NOUN
admet-1513	1458	2	.	.	PUNCT
admet-1513	1459	1	[	[	X
admet-1513	1459	2	182	182	NUM
admet-1513	1459	3	]	]	PUNCT
admet-1513	1459	4	y.	y.	PROPN
admet-1513	1459	5	zhao	zhao	PROPN
admet-1513	1459	6	,	,	PUNCT
admet-1513	1459	7	n.	n.	NOUN
admet-1513	1459	8	rafatian	rafatian	PROPN
admet-1513	1459	9	,	,	PUNCT
admet-1513	1459	10	n.t	n.t	PROPN
admet-1513	1459	11	.	.	PROPN
admet-1513	1459	12	feric	feric	PROPN
admet-1513	1459	13	,	,	PUNCT
admet-1513	1459	14	b.j	b.j	PROPN
admet-1513	1459	15	.	.	PROPN
admet-1513	1459	16	cox	cox	PROPN
admet-1513	1459	17	,	,	PUNCT
admet-1513	1459	18	r.	r.	PROPN
admet-1513	1459	19	aschar	aschar	PROPN
admet-1513	1459	20	-	-	PUNCT
admet-1513	1459	21	sobbi	sobbi	NOUN
admet-1513	1459	22	,	,	PUNCT
admet-1513	1459	23	e.y	e.y	PROPN
admet-1513	1459	24	.	.	PROPN
admet-1513	1459	25	wang	wang	PROPN
admet-1513	1459	26	,	,	PUNCT
admet-1513	1459	27	p.	p.	NOUN
admet-1513	1459	28	aggarwal	aggarwal	PROPN
admet-1513	1459	29	,	,	PUNCT
admet-1513	1459	30	b.	b.	PROPN
admet-1513	1459	31	zhang	zhang	PROPN
admet-1513	1459	32	,	,	PUNCT
admet-1513	1459	33	g.	g.	PROPN
admet-1513	1459	34	conant	conant	PROPN
admet-1513	1459	35	,	,	PUNCT
admet-1513	1459	36	k.	k.	PROPN
admet-1513	1459	37	ronaldson	ronaldson	PROPN
admet-1513	1459	38	-	-	PUNCT
admet-1513	1459	39	bouchard	bouchard	PROPN
admet-1513	1459	40	,	,	PUNCT
admet-1513	1459	41	a.	a.	NOUN
admet-1513	1459	42	pahnke	pahnke	PROPN
admet-1513	1459	43	,	,	PUNCT
admet-1513	1459	44	s.	s.	PROPN
admet-1513	1459	45	protze	protze	PROPN
admet-1513	1459	46	,	,	PUNCT
admet-1513	1459	47	j.h	j.h	PROPN
admet-1513	1459	48	.	.	PROPN
admet-1513	1459	49	lee	lee	PROPN
admet-1513	1459	50	,	,	PUNCT
admet-1513	1459	51	l.	l.	PROPN
admet-1513	1459	52	davenport	davenport	PROPN
admet-1513	1459	53	huyer	huyer	PROPN
admet-1513	1459	54	,	,	PUNCT
admet-1513	1459	55	d.	d.	PROPN
admet-1513	1459	56	jekic	jekic	PROPN
admet-1513	1459	57	,	,	PUNCT
admet-1513	1459	58	a.	a.	NOUN
admet-1513	1459	59	wickeler	wickeler	PROPN
admet-1513	1459	60	,	,	PUNCT
admet-1513	1459	61	h.e	h.e	PROPN
admet-1513	1459	62	.	.	PROPN
admet-1513	1459	63	naguib	naguib	PROPN
admet-1513	1459	64	,	,	PUNCT
admet-1513	1459	65	g.m	g.m	PROPN
admet-1513	1459	66	.	.	PROPN
admet-1513	1459	67	keller	keller	PROPN
admet-1513	1459	68	,	,	PUNCT
admet-1513	1459	69	g.	g.	PROPN
admet-1513	1459	70	vunjak	vunjak	PROPN
admet-1513	1459	71	-	-	PUNCT
admet-1513	1459	72	novakovic	novakovic	ADJ
admet-1513	1459	73	,	,	PUNCT
admet-1513	1459	74	u.	u.	PROPN
admet-1513	1459	75	broeckel	broeckel	PROPN
admet-1513	1459	76	,	,	PUNCT
admet-1513	1459	77	p.h	p.h	PROPN
admet-1513	1459	78	.	.	PROPN
admet-1513	1459	79	backx	backx	PROPN
admet-1513	1459	80	,	,	PUNCT
admet-1513	1459	81	m.	m.	NOUN
admet-1513	1459	82	radisic	radisic	NOUN
admet-1513	1459	83	.	.	PUNCT
admet-1513	1460	1	a	a	DET
admet-1513	1460	2	platform	platform	NOUN
admet-1513	1460	3	for	for	ADP
admet-1513	1460	4	generation	generation	NOUN
admet-1513	1460	5	of	of	ADP
admet-1513	1460	6	chamber	chamber	NOUN
admet-1513	1460	7	-	-	PUNCT
admet-1513	1460	8	specific	specific	ADJ
admet-1513	1460	9	cardiac	cardiac	ADJ
admet-1513	1460	10	tissues	tissue	NOUN
admet-1513	1460	11	and	and	CCONJ
admet-1513	1460	12	disease	disease	NOUN
admet-1513	1460	13	modeling	modeling	NOUN
admet-1513	1460	14	.	.	PUNCT
admet-1513	1461	1	cell	cell	NOUN
admet-1513	1461	2	176	176	NUM
admet-1513	1461	3	(	(	PUNCT
admet-1513	1461	4	2019	2019	NUM
admet-1513	1461	5	)	)	PUNCT
admet-1513	1461	6	913	913	NUM
admet-1513	1461	7	-	-	SYM
admet-1513	1461	8	927.e18	927.e18	PROPN
admet-1513	1461	9	.	.	PUNCT
admet-1513	1461	10	https://doi.org/10.1016/j.cell.2018.11.042	https://doi.org/10.1016/j.cell.2018.11.042	NOUN
admet-1513	1461	11	.	.	PUNCT
admet-1513	1462	1	[	[	X
admet-1513	1462	2	183	183	NUM
admet-1513	1462	3	]	]	SYM
admet-1513	1462	4	n.t	n.t	PROPN
admet-1513	1462	5	.	.	PROPN
admet-1513	1462	6	feric	feric	PROPN
admet-1513	1462	7	,	,	PUNCT
admet-1513	1462	8	i.	i.	PROPN
admet-1513	1462	9	pallotta	pallotta	PROPN
admet-1513	1462	10	,	,	PUNCT
admet-1513	1462	11	r.	r.	PROPN
admet-1513	1462	12	singh	singh	PROPN
admet-1513	1462	13	,	,	PUNCT
admet-1513	1462	14	d.r	d.r	PROPN
admet-1513	1462	15	.	.	PROPN
admet-1513	1462	16	bogdanowicz	bogdanowicz	PROPN
admet-1513	1462	17	,	,	PUNCT
admet-1513	1462	18	m.	m.	NOUN
admet-1513	1462	19	gustilo	gustilo	PROPN
admet-1513	1462	20	,	,	PUNCT
admet-1513	1462	21	k.	k.	PROPN
admet-1513	1462	22	chaudhary	chaudhary	PROPN
admet-1513	1462	23	,	,	PUNCT
admet-1513	1462	24	r.n	r.n	PROPN
admet-1513	1462	25	.	.	PROPN
admet-1513	1462	26	willette	willette	PROPN
admet-1513	1462	27	,	,	PUNCT
admet-1513	1462	28	t.	t.	PROPN
admet-1513	1462	29	chendrimada	chendrimada	PROPN
admet-1513	1462	30	,	,	PUNCT
admet-1513	1462	31	x.	x.	PROPN
admet-1513	1462	32	xu	xu	PROPN
admet-1513	1462	33	,	,	PUNCT
admet-1513	1462	34	m.p	m.p	PROPN
admet-1513	1462	35	.	.	PROPN
admet-1513	1462	36	graziano	graziano	PROPN
admet-1513	1462	37	,	,	PUNCT
admet-1513	1462	38	r.	r.	PROPN
admet-1513	1462	39	aschar	aschar	PROPN
admet-1513	1462	40	-	-	PUNCT
admet-1513	1462	41	sobbi	sobbi	NOUN
admet-1513	1462	42	.	.	PUNCT
admet-1513	1463	1	engineered	engineer	VERB
admet-1513	1463	2	cardiac	cardiac	ADJ
admet-1513	1463	3	tissues	tissue	NOUN
admet-1513	1463	4	generated	generate	VERB
admet-1513	1463	5	in	in	ADP
admet-1513	1463	6	the	the	DET
admet-1513	1463	7	biowire	biowire	NOUN
admet-1513	1463	8	™	™	PROPN
admet-1513	1463	9	ii	ii	PROPN
admet-1513	1463	10	:	:	PUNCT
admet-1513	1463	11	a	a	DET
admet-1513	1463	12	platform	platform	NOUN
admet-1513	1463	13	for	for	ADP
admet-1513	1463	14	human	human	NOUN
admet-1513	1463	15	-	-	PUNCT
admet-1513	1463	16	based	base	VERB
admet-1513	1463	17	drug	drug	NOUN
admet-1513	1463	18	discovery	discovery	NOUN
admet-1513	1463	19	.	.	PUNCT
admet-1513	1464	1	toxicol	toxicol	PROPN
admet-1513	1464	2	.	.	PUNCT
admet-1513	1465	1	sci	sci	PROPN
admet-1513	1465	2	.	.	PROPN
admet-1513	1466	1	172	172	NUM
admet-1513	1466	2	(	(	PUNCT
admet-1513	1466	3	2019	2019	NUM
admet-1513	1466	4	)	)	PUNCT
admet-1513	1466	5	89	89	NUM
admet-1513	1466	6	-	-	SYM
admet-1513	1466	7	97	97	NUM
admet-1513	1466	8	.	.	PUNCT
admet-1513	1467	1	https://doi.org/10.1093/toxsci/kfz168	https://doi.org/10.1093/toxsci/kfz168	NOUN
admet-1513	1467	2	.	.	PUNCT
admet-1513	1467	3	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	1468	1	https://doi.org/10.1113/jp270526	https://doi.org/10.1113/jp270526	PROPN
admet-1513	1468	2	https://doi.org/10.1007/s10557-016-6711-0	https://doi.org/10.1007/s10557-016-6711-0	PROPN
admet-1513	1468	3	https://doi.org/10.1007/s10557-016-6711-0	https://doi.org/10.1007/s10557-016-6711-0	NUM
admet-1513	1468	4	https://doi.org/10.2174/138920008786485083	https://doi.org/10.2174/138920008786485083	NOUN
admet-1513	1468	5	https://doi.org/10.2174/138920008786485083	https://doi.org/10.2174/138920008786485083	X
admet-1513	1469	1	https://doi.org/10.1016/j.vascn.2016.12.003	https://doi.org/10.1016/j.vascn.2016.12.003	VERB
admet-1513	1469	2	https://doi.org/10.1016/j.vascn.2016.12.003	https://doi.org/10.1016/j.vascn.2016.12.003	ADJ
admet-1513	1469	3	https://doi.org/10.1016/j.jphs.2018.02.005	https://doi.org/10.1016/j.jphs.2018.02.005	VERB
admet-1513	1469	4	https://doi.org/10.1089/adt.2014.601	https://doi.org/10.1089/adt.2014.601	NOUN
admet-1513	1469	5	https://doi.org/10.1016/j.vascn.2016.04.007	https://doi.org/10.1016/j.vascn.2016.04.007	VERB
admet-1513	1469	6	https://doi.org/10.1002/jbm.b.33742	https://doi.org/10.1002/jbm.b.33742	ADJ
admet-1513	1469	7	https://doi.org/10.1016/j.biomaterials.2019.03.023	https://doi.org/10.1016/j.biomaterials.2019.03.023	PROPN
admet-1513	1469	8	https://doi.org/10.1016/j.stem.2019.03.009	https://doi.org/10.1016/j.stem.2019.03.009	NUM
admet-1513	1469	9	https://doi.org/10.1016/j.biomaterials.2017.07.021	https://doi.org/10.1016/j.biomaterials.2017.07.021	NOUN
admet-1513	1469	10	https://doi.org/10.1016/j.cell.2018.11.042	https://doi.org/10.1016/j.cell.2018.11.042	PROPN
admet-1513	1469	11	https://doi.org/10.1093/toxsci/kfz168	https://doi.org/10.1093/toxsci/kfz168	VERB
admet-1513	1469	12	venkatesh	venkatesh	PROPN
admet-1513	1469	13	chunduri	chunduri	PROPN
admet-1513	1469	14	and	and	CCONJ
admet-1513	1469	15	srinivas	srinivas	PROPN
admet-1513	1469	16	maddi	maddi	PROPN
admet-1513	1469	17	admet	admet	PROPN
admet-1513	1469	18	&	&	CCONJ
admet-1513	1469	19	dmpk	dmpk	PROPN
admet-1513	1469	20	11(1	11(1	NUM
admet-1513	1469	21	)	)	PUNCT
admet-1513	1469	22	(	(	PUNCT
admet-1513	1469	23	2023	2023	NUM
admet-1513	1469	24	)	)	PUNCT
admet-1513	1469	25	1	1	NUM
admet-1513	1469	26	-	-	SYM
admet-1513	1469	27	32	32	NUM
admet-1513	1469	28	30	30	NUM
admet-1513	1469	29	[	[	X
admet-1513	1469	30	184	184	NUM
admet-1513	1469	31	]	]	X
admet-1513	1469	32	y.	y.	PROPN
admet-1513	1469	33	qu	qu	PROPN
admet-1513	1469	34	,	,	PUNCT
admet-1513	1469	35	n.	n.	PROPN
admet-1513	1469	36	feric	feric	PROPN
admet-1513	1469	37	,	,	PUNCT
admet-1513	1469	38	i.	i.	PROPN
admet-1513	1469	39	pallotta	pallotta	PROPN
admet-1513	1469	40	,	,	PUNCT
admet-1513	1469	41	r.	r.	PROPN
admet-1513	1469	42	singh	singh	PROPN
admet-1513	1469	43	,	,	PUNCT
admet-1513	1469	44	r.	r.	PROPN
admet-1513	1469	45	sobbi	sobbi	PROPN
admet-1513	1469	46	,	,	PUNCT
admet-1513	1469	47	h.m	h.m	PROPN
admet-1513	1469	48	.	.	PROPN
admet-1513	1469	49	vargas	vargas	PROPN
admet-1513	1469	50	.	.	PUNCT
admet-1513	1469	51	inotropic	inotropic	ADJ
admet-1513	1469	52	assessment	assessment	NOUN
admet-1513	1469	53	in	in	ADP
admet-1513	1469	54	engineered	engineer	VERB
admet-1513	1469	55	3d	3d	NUM
admet-1513	1469	56	cardiac	cardiac	ADJ
admet-1513	1469	57	tissues	tissue	NOUN
admet-1513	1469	58	using	use	VERB
admet-1513	1469	59	human	human	ADJ
admet-1513	1469	60	induced	induced	ADJ
admet-1513	1469	61	pluripotent	pluripotent	NOUN
admet-1513	1469	62	stem	stem	NOUN
admet-1513	1469	63	cell	cell	NOUN
admet-1513	1469	64	-	-	PUNCT
admet-1513	1469	65	derived	derive	VERB
admet-1513	1469	66	cardiomyocytes	cardiomyocyte	NOUN
admet-1513	1469	67	in	in	ADP
admet-1513	1469	68	the	the	DET
admet-1513	1469	69	biowiretm	biowiretm	NOUN
admet-1513	1469	70	ii	ii	PROPN
admet-1513	1469	71	platform	platform	NOUN
admet-1513	1469	72	.	.	PUNCT
admet-1513	1470	1	j.	j.	PROPN
admet-1513	1470	2	pharmacol	pharmacol	PROPN
admet-1513	1470	3	.	.	PUNCT
admet-1513	1471	1	toxicol	toxicol	PROPN
admet-1513	1471	2	.	.	PUNCT
admet-1513	1472	1	methods	method	NOUN
admet-1513	1472	2	105	105	NUM
admet-1513	1472	3	(	(	PUNCT
admet-1513	1472	4	2020	2020	NUM
admet-1513	1472	5	)	)	PUNCT
admet-1513	1472	6	106886	106886	NUM
admet-1513	1472	7	.	.	PUNCT
admet-1513	1473	1	https://doi.org/10.1016/j.vascn.2020.106886	https://doi.org/10.1016/j.vascn.2020.106886	PROPN
admet-1513	1473	2	.	.	PUNCT
admet-1513	1474	1	[	[	X
admet-1513	1474	2	185	185	NUM
admet-1513	1474	3	]	]	X
admet-1513	1474	4	r.a	r.a	PROPN
admet-1513	1474	5	.	.	PROPN
admet-1513	1474	6	li	li	PROPN
admet-1513	1474	7	,	,	PUNCT
admet-1513	1474	8	w.	w.	PROPN
admet-1513	1474	9	keung	keung	PROPN
admet-1513	1474	10	,	,	PUNCT
admet-1513	1474	11	t.j	t.j	PROPN
admet-1513	1474	12	.	.	PROPN
admet-1513	1474	13	cashman	cashman	PROPN
admet-1513	1474	14	,	,	PUNCT
admet-1513	1474	15	p.c	p.c	PROPN
admet-1513	1474	16	.	.	PROPN
admet-1513	1474	17	backeris	backeris	PROPN
admet-1513	1474	18	,	,	PUNCT
admet-1513	1474	19	b.v	b.v	PROPN
admet-1513	1474	20	.	.	PROPN
admet-1513	1474	21	johnson	johnson	PROPN
admet-1513	1474	22	,	,	PUNCT
admet-1513	1474	23	e.s	e.s	PROPN
admet-1513	1474	24	.	.	PROPN
admet-1513	1474	25	bardot	bardot	PROPN
admet-1513	1474	26	,	,	PUNCT
admet-1513	1474	27	a.o.t	a.o.t	PROPN
admet-1513	1474	28	.	.	PUNCT
admet-1513	1475	1	wong	wong	PROPN
admet-1513	1475	2	,	,	PUNCT
admet-1513	1475	3	p.k.w	p.k.w	PROPN
admet-1513	1475	4	.	.	PUNCT
admet-1513	1475	5	chan	chan	PROPN
admet-1513	1475	6	,	,	PUNCT
admet-1513	1475	7	c.w.y	c.w.y	PROPN
admet-1513	1475	8	.	.	PUNCT
admet-1513	1476	1	chan	chan	PROPN
admet-1513	1476	2	,	,	PUNCT
admet-1513	1476	3	k.d	k.d	PROPN
admet-1513	1476	4	.	.	PROPN
admet-1513	1476	5	costa	costa	PROPN
admet-1513	1476	6	.	.	PUNCT
admet-1513	1477	1	bioengineering	bioengineere	VERB
admet-1513	1477	2	an	an	DET
admet-1513	1477	3	electro	electro	NOUN
admet-1513	1477	4	-	-	PUNCT
admet-1513	1477	5	mechanically	mechanically	ADV
admet-1513	1477	6	functional	functional	ADJ
admet-1513	1477	7	miniature	miniature	ADJ
admet-1513	1477	8	ventricular	ventricular	ADJ
admet-1513	1477	9	heart	heart	NOUN
admet-1513	1477	10	chamber	chamber	NOUN
admet-1513	1477	11	from	from	ADP
admet-1513	1477	12	human	human	ADJ
admet-1513	1477	13	pluripotent	pluripotent	NOUN
admet-1513	1477	14	stem	stem	NOUN
admet-1513	1477	15	cells	cell	NOUN
admet-1513	1477	16	.	.	PUNCT
admet-1513	1478	1	biomaterials	biomaterial	NOUN
admet-1513	1478	2	163	163	NUM
admet-1513	1478	3	(	(	PUNCT
admet-1513	1478	4	2018	2018	NUM
admet-1513	1478	5	)	)	PUNCT
admet-1513	1478	6	116	116	NUM
admet-1513	1478	7	-	-	SYM
admet-1513	1478	8	127	127	NUM
admet-1513	1478	9	.	.	PUNCT
admet-1513	1479	1	https://doi.org/10.1016/j.biomaterials.2018.02.024	https://doi.org/10.1016/j.biomaterials.2018.02.024	VERB
admet-1513	1479	2	.	.	PUNCT
admet-1513	1480	1	[	[	X
admet-1513	1480	2	186	186	NUM
admet-1513	1480	3	]	]	PUNCT
admet-1513	1480	4	w.	w.	PROPN
admet-1513	1480	5	keung	keung	PROPN
admet-1513	1480	6	,	,	PUNCT
admet-1513	1480	7	p.k.w	p.k.w	INTJ
admet-1513	1480	8	.	.	PUNCT
admet-1513	1481	1	chan	chan	PROPN
admet-1513	1481	2	,	,	PUNCT
admet-1513	1481	3	p.c	p.c	PROPN
admet-1513	1481	4	.	.	PROPN
admet-1513	1481	5	backeris	backeris	PROPN
admet-1513	1481	6	,	,	PUNCT
admet-1513	1481	7	e.k	e.k	PROPN
admet-1513	1481	8	.	.	PROPN
admet-1513	1481	9	lee	lee	PROPN
admet-1513	1481	10	,	,	PUNCT
admet-1513	1481	11	n.	n.	PROPN
admet-1513	1481	12	wong	wong	PROPN
admet-1513	1481	13	,	,	PUNCT
admet-1513	1481	14	a.o.t	a.o.t	PROPN
admet-1513	1481	15	.	.	PUNCT
admet-1513	1481	16	wong	wong	PROPN
admet-1513	1481	17	,	,	PUNCT
admet-1513	1481	18	g.k.y	g.k.y	PROPN
admet-1513	1481	19	.	.	PROPN
admet-1513	1481	20	wong	wong	PROPN
admet-1513	1481	21	,	,	PUNCT
admet-1513	1481	22	c.w.y	c.w.y	PROPN
admet-1513	1481	23	.	.	PUNCT
admet-1513	1482	1	chan	chan	PROPN
admet-1513	1482	2	,	,	PUNCT
admet-1513	1482	3	b.	b.	PROPN
admet-1513	1482	4	fermini	fermini	PROPN
admet-1513	1482	5	,	,	PUNCT
admet-1513	1482	6	k.d	k.d	PROPN
admet-1513	1482	7	.	.	PROPN
admet-1513	1482	8	costa	costa	PROPN
admet-1513	1482	9	,	,	PUNCT
admet-1513	1482	10	r.a	r.a	PROPN
admet-1513	1482	11	.	.	PROPN
admet-1513	1482	12	li	li	PROPN
admet-1513	1482	13	.	.	PUNCT
admet-1513	1483	1	human	human	ADJ
admet-1513	1483	2	cardiac	cardiac	ADJ
admet-1513	1483	3	ventricular	ventricular	ADJ
admet-1513	1483	4	-	-	PUNCT
admet-1513	1483	5	like	like	ADJ
admet-1513	1483	6	organoid	organoid	PROPN
admet-1513	1483	7	chambers	chamber	NOUN
admet-1513	1483	8	and	and	CCONJ
admet-1513	1483	9	tissue	tissue	NOUN
admet-1513	1483	10	strips	strip	NOUN
admet-1513	1483	11	from	from	ADP
admet-1513	1483	12	pluripotent	pluripotent	ADJ
admet-1513	1483	13	stem	stem	NOUN
admet-1513	1483	14	cells	cell	NOUN
admet-1513	1483	15	as	as	ADP
admet-1513	1483	16	a	a	DET
admet-1513	1483	17	two	two	NUM
admet-1513	1483	18	-	-	PUNCT
admet-1513	1483	19	tiered	tiere	VERB
admet-1513	1483	20	assay	assay	NOUN
admet-1513	1483	21	for	for	ADP
admet-1513	1483	22	inotropic	inotropic	ADJ
admet-1513	1483	23	responses	response	NOUN
admet-1513	1483	24	.	.	PUNCT
admet-1513	1484	1	clin	clin	PROPN
admet-1513	1484	2	.	.	PUNCT
admet-1513	1485	1	pharmacol	pharmacol	PROPN
admet-1513	1485	2	.	.	PUNCT
admet-1513	1486	1	ther	ther	PROPN
admet-1513	1486	2	.	.	PUNCT
admet-1513	1487	1	106	106	NUM
admet-1513	1487	2	(	(	PUNCT
admet-1513	1487	3	2019	2019	NUM
admet-1513	1487	4	)	)	PUNCT
admet-1513	1487	5	402	402	NUM
admet-1513	1487	6	-	-	SYM
admet-1513	1487	7	414	414	NUM
admet-1513	1487	8	.	.	PUNCT
admet-1513	1488	1	https://doi.org/10.1002/cpt.1385	https://doi.org/10.1002/cpt.1385	PROPN
admet-1513	1488	2	.	.	PUNCT
admet-1513	1489	1	[	[	X
admet-1513	1489	2	187	187	NUM
admet-1513	1489	3	]	]	X
admet-1513	1489	4	c.r	c.r	PROPN
admet-1513	1489	5	.	.	PROPN
admet-1513	1489	6	archer	archer	PROPN
admet-1513	1489	7	,	,	PUNCT
admet-1513	1489	8	r.	r.	PROPN
admet-1513	1489	9	sargeant	sargeant	PROPN
admet-1513	1489	10	,	,	PUNCT
admet-1513	1489	11	j.	j.	PROPN
admet-1513	1489	12	basak	basak	PROPN
admet-1513	1489	13	,	,	PUNCT
admet-1513	1489	14	j.	j.	PROPN
admet-1513	1489	15	pilling	pilling	PROPN
admet-1513	1489	16	,	,	PUNCT
admet-1513	1489	17	j.r	j.r	PROPN
admet-1513	1489	18	.	.	PROPN
admet-1513	1489	19	barnes	barnes	PROPN
admet-1513	1489	20	,	,	PUNCT
admet-1513	1489	21	a.	a.	NOUN
admet-1513	1489	22	pointon	pointon	PROPN
admet-1513	1489	23	.	.	PUNCT
admet-1513	1490	1	characterization	characterization	NOUN
admet-1513	1490	2	and	and	CCONJ
admet-1513	1490	3	validation	validation	NOUN
admet-1513	1490	4	of	of	ADP
admet-1513	1490	5	a	a	DET
admet-1513	1490	6	human	human	ADJ
admet-1513	1490	7	3d	3d	PROPN
admet-1513	1490	8	cardiac	cardiac	ADJ
admet-1513	1490	9	microtissue	microtissue	NOUN
admet-1513	1490	10	for	for	ADP
admet-1513	1490	11	the	the	DET
admet-1513	1490	12	assessment	assessment	NOUN
admet-1513	1490	13	of	of	ADP
admet-1513	1490	14	changes	change	NOUN
admet-1513	1490	15	in	in	ADP
admet-1513	1490	16	cardiac	cardiac	ADJ
admet-1513	1490	17	pathology	pathology	NOUN
admet-1513	1490	18	.	.	PUNCT
admet-1513	1491	1	sci	sci	PROPN
admet-1513	1491	2	.	.	PROPN
admet-1513	1491	3	rep	rep	PROPN
admet-1513	1491	4	.	.	PROPN
admet-1513	1491	5	8	8	NUM
admet-1513	1491	6	(	(	PUNCT
admet-1513	1491	7	2018	2018	NUM
admet-1513	1491	8	)	)	PUNCT
admet-1513	1491	9	10160	10160	NUM
admet-1513	1491	10	.	.	PUNCT
admet-1513	1492	1	https://doi.org/10.1038/s41598-018-28393-y	https://doi.org/10.1038/s41598-018-28393-y	NOUN
admet-1513	1492	2	.	.	PUNCT
admet-1513	1493	1	[	[	X
admet-1513	1493	2	188	188	NUM
admet-1513	1493	3	]	]	PUNCT
admet-1513	1493	4	d.j	d.j	PROPN
admet-1513	1493	5	.	.	PROPN
admet-1513	1493	6	richards	richards	PROPN
admet-1513	1493	7	,	,	PUNCT
admet-1513	1493	8	y.	y.	PROPN
admet-1513	1493	9	li	li	PROPN
admet-1513	1493	10	,	,	PUNCT
admet-1513	1493	11	c.m	c.m	PROPN
admet-1513	1493	12	.	.	PROPN
admet-1513	1493	13	kerr	kerr	PROPN
admet-1513	1493	14	,	,	PUNCT
admet-1513	1493	15	j.	j.	PROPN
admet-1513	1493	16	yao	yao	PROPN
admet-1513	1493	17	,	,	PUNCT
admet-1513	1493	18	g.c	g.c	PROPN
admet-1513	1493	19	.	.	PROPN
admet-1513	1493	20	beeson	beeson	PROPN
admet-1513	1493	21	,	,	PUNCT
admet-1513	1493	22	r.c	r.c	PROPN
admet-1513	1493	23	.	.	PROPN
admet-1513	1493	24	coyle	coyle	PROPN
admet-1513	1493	25	,	,	PUNCT
admet-1513	1493	26	x.	x.	PROPN
admet-1513	1493	27	chen	chen	PROPN
admet-1513	1493	28	,	,	PUNCT
admet-1513	1493	29	j.	j.	PROPN
admet-1513	1493	30	jia	jia	PROPN
admet-1513	1493	31	,	,	PUNCT
admet-1513	1493	32	b.	b.	PROPN
admet-1513	1493	33	damon	damon	PROPN
admet-1513	1493	34	,	,	PUNCT
admet-1513	1493	35	r.	r.	PROPN
admet-1513	1493	36	wilson	wilson	PROPN
admet-1513	1493	37	,	,	PUNCT
admet-1513	1493	38	e.	e.	PROPN
admet-1513	1493	39	starr	starr	PROPN
admet-1513	1493	40	hazard	hazard	PROPN
admet-1513	1493	41	,	,	PUNCT
admet-1513	1493	42	g.	g.	PROPN
admet-1513	1493	43	hardiman	hardiman	PROPN
admet-1513	1493	44	,	,	PUNCT
admet-1513	1493	45	d.r	d.r	PROPN
admet-1513	1493	46	.	.	PROPN
admet-1513	1493	47	menick	menick	PROPN
admet-1513	1493	48	,	,	PUNCT
admet-1513	1493	49	c.c	c.c	PROPN
admet-1513	1493	50	.	.	PROPN
admet-1513	1493	51	beeson	beeson	PROPN
admet-1513	1493	52	,	,	PUNCT
admet-1513	1493	53	h.	h.	PROPN
admet-1513	1493	54	yao	yao	PROPN
admet-1513	1493	55	,	,	PUNCT
admet-1513	1493	56	t.	t.	PROPN
admet-1513	1493	57	ye	ye	PROPN
admet-1513	1493	58	,	,	PUNCT
admet-1513	1493	59	y.	y.	PROPN
admet-1513	1493	60	mei	mei	PROPN
admet-1513	1493	61	.	.	PUNCT
admet-1513	1494	1	human	human	ADJ
admet-1513	1494	2	cardiac	cardiac	ADJ
admet-1513	1494	3	organoids	organoid	NOUN
admet-1513	1494	4	for	for	ADP
admet-1513	1494	5	the	the	DET
admet-1513	1494	6	modelling	modelling	NOUN
admet-1513	1494	7	of	of	ADP
admet-1513	1494	8	myocardial	myocardial	ADJ
admet-1513	1494	9	infarction	infarction	NOUN
admet-1513	1494	10	and	and	CCONJ
admet-1513	1494	11	drug	drug	NOUN
admet-1513	1494	12	cardiotoxicity	cardiotoxicity	NOUN
admet-1513	1494	13	.	.	PUNCT
admet-1513	1495	1	nat	nat	PROPN
admet-1513	1495	2	.	.	PROPN
admet-1513	1495	3	biomed	biome	VERB
admet-1513	1495	4	.	.	PUNCT
admet-1513	1496	1	eng	eng	PROPN
admet-1513	1496	2	.	.	PROPN
admet-1513	1496	3	4	4	NUM
admet-1513	1496	4	(	(	PUNCT
admet-1513	1496	5	2020	2020	NUM
admet-1513	1496	6	)	)	PUNCT
admet-1513	1496	7	446462	446462	NUM
admet-1513	1496	8	.	.	PUNCT
admet-1513	1497	1	https://doi.org/10.1038/s41551-020-0539-4	https://doi.org/10.1038/s41551-020-0539-4	NUM
admet-1513	1497	2	.	.	PUNCT
admet-1513	1498	1	[	[	X
admet-1513	1498	2	189	189	NUM
admet-1513	1498	3	]	]	X
admet-1513	1498	4	r.e	r.e	PROPN
admet-1513	1498	5	.	.	PROPN
admet-1513	1498	6	ahmed	ahmed	PROPN
admet-1513	1498	7	,	,	PUNCT
admet-1513	1498	8	t.	t.	PROPN
admet-1513	1498	9	anzai	anzai	NOUN
admet-1513	1498	10	,	,	PUNCT
admet-1513	1498	11	n.	n.	PROPN
admet-1513	1498	12	chanthra	chanthra	PROPN
admet-1513	1498	13	,	,	PUNCT
admet-1513	1498	14	h.	h.	PROPN
admet-1513	1498	15	uosaki	uosaki	PROPN
admet-1513	1498	16	.	.	PUNCT
admet-1513	1499	1	a	a	DET
admet-1513	1499	2	brief	brief	ADJ
admet-1513	1499	3	review	review	NOUN
admet-1513	1499	4	of	of	ADP
admet-1513	1499	5	current	current	ADJ
admet-1513	1499	6	maturation	maturation	NOUN
admet-1513	1499	7	methods	method	NOUN
admet-1513	1499	8	for	for	ADP
admet-1513	1499	9	human	human	ADJ
admet-1513	1499	10	induced	induced	ADJ
admet-1513	1499	11	pluripotent	pluripotent	ADJ
admet-1513	1499	12	stem	stem	NOUN
admet-1513	1499	13	cells	cell	NOUN
admet-1513	1499	14	-	-	PUNCT
admet-1513	1499	15	derived	derive	VERB
admet-1513	1499	16	cardiomyocytes	cardiomyocyte	NOUN
admet-1513	1499	17	.	.	PUNCT
admet-1513	1500	1	front	front	ADJ
admet-1513	1500	2	.	.	PUNCT
admet-1513	1501	1	cell	cell	PROPN
admet-1513	1501	2	dev	dev	PROPN
admet-1513	1501	3	.	.	PUNCT
admet-1513	1502	1	biol	biol	PROPN
admet-1513	1502	2	.	.	PUNCT
admet-1513	1503	1	8	8	NUM
admet-1513	1503	2	(	(	PUNCT
admet-1513	1503	3	2020	2020	NUM
admet-1513	1503	4	)	)	PUNCT
admet-1513	1503	5	178	178	NUM
admet-1513	1503	6	.	.	PUNCT
admet-1513	1504	1	https://doi.org/10.3389/fcell.2020.00178	https://doi.org/10.3389/fcell.2020.00178	PROPN
admet-1513	1504	2	.	.	PUNCT
admet-1513	1505	1	[	[	X
admet-1513	1505	2	190	190	NUM
admet-1513	1505	3	]	]	PUNCT
admet-1513	1505	4	m.	m.	NOUN
admet-1513	1505	5	pavkovic	pavkovic	PROPN
admet-1513	1505	6	,	,	PUNCT
admet-1513	1505	7	v.s.	v.s.	PROPN
admet-1513	1505	8	vaidya	vaidya	PROPN
admet-1513	1505	9	.	.	PUNCT
admet-1513	1505	10	micrornas	microrna	NOUN
admet-1513	1505	11	and	and	CCONJ
admet-1513	1505	12	drug	drug	NOUN
admet-1513	1505	13	-	-	PUNCT
admet-1513	1505	14	induced	induce	VERB
admet-1513	1505	15	kidney	kidney	NOUN
admet-1513	1505	16	injury	injury	NOUN
admet-1513	1505	17	.	.	PUNCT
admet-1513	1506	1	pharmacol	pharmacol	PROPN
admet-1513	1506	2	.	.	PUNCT
admet-1513	1507	1	ther	ther	PROPN
admet-1513	1507	2	.	.	PUNCT
admet-1513	1508	1	163	163	NUM
admet-1513	1508	2	(	(	PUNCT
admet-1513	1508	3	2016	2016	NUM
admet-1513	1508	4	)	)	PUNCT
admet-1513	1508	5	48	48	NUM
admet-1513	1508	6	-	-	SYM
admet-1513	1508	7	57	57	NUM
admet-1513	1508	8	.	.	PUNCT
admet-1513	1509	1	https://doi.org/10.1016/j.pharmthera.2016.03.016	https://doi.org/10.1016/j.pharmthera.2016.03.016	PROPN
admet-1513	1509	2	.	.	PUNCT
admet-1513	1510	1	[	[	X
admet-1513	1510	2	191	191	NUM
admet-1513	1510	3	]	]	X
admet-1513	1510	4	j.y	j.y	PROPN
admet-1513	1510	5	.	.	PROPN
admet-1513	1510	6	soo	soo	PROPN
admet-1513	1510	7	,	,	PUNCT
admet-1513	1510	8	j.	j.	PROPN
admet-1513	1510	9	jansen	jansen	PROPN
admet-1513	1510	10	,	,	PUNCT
admet-1513	1510	11	r.	r.	PROPN
admet-1513	1510	12	masereeuw	masereeuw	PROPN
admet-1513	1510	13	,	,	PUNCT
admet-1513	1510	14	m.h	m.h	PROPN
admet-1513	1510	15	.	.	PROPN
admet-1513	1510	16	little	little	ADJ
admet-1513	1510	17	.	.	PUNCT
admet-1513	1510	18	advances	advance	NOUN
admet-1513	1510	19	in	in	ADP
admet-1513	1510	20	predictive	predictive	NOUN
admet-1513	1510	21	in	in	ADP
admet-1513	1510	22	vitro	vitro	X
admet-1513	1510	23	models	model	NOUN
admet-1513	1510	24	of	of	ADP
admet-1513	1510	25	drug	drug	NOUN
admet-1513	1510	26	-	-	PUNCT
admet-1513	1510	27	induced	induce	VERB
admet-1513	1510	28	nephrotoxicity	nephrotoxicity	NOUN
admet-1513	1510	29	.	.	PUNCT
admet-1513	1511	1	nat	nat	PROPN
admet-1513	1511	2	.	.	PUNCT
admet-1513	1512	1	rev	rev	PROPN
admet-1513	1512	2	.	.	PROPN
admet-1513	1512	3	nephrol	nephrol	PROPN
admet-1513	1512	4	.	.	PUNCT
admet-1513	1513	1	14	14	NUM
admet-1513	1513	2	(	(	PUNCT
admet-1513	1513	3	2018	2018	NUM
admet-1513	1513	4	)	)	PUNCT
admet-1513	1513	5	378	378	NUM
admet-1513	1513	6	-	-	SYM
admet-1513	1513	7	393	393	NUM
admet-1513	1513	8	.	.	PUNCT
admet-1513	1514	1	https://doi.org/10.1038/s41581-018-0003-9	https://doi.org/10.1038/s41581-018-0003-9	NUM
admet-1513	1514	2	.	.	PUNCT
admet-1513	1515	1	[	[	X
admet-1513	1515	2	192	192	NUM
admet-1513	1515	3	]	]	PUNCT
admet-1513	1515	4	m.	m.	NOUN
admet-1513	1515	5	adler	adler	PROPN
admet-1513	1515	6	,	,	PUNCT
admet-1513	1515	7	s.	s.	PROPN
admet-1513	1515	8	ramm	ramm	PROPN
admet-1513	1515	9	,	,	PUNCT
admet-1513	1515	10	m.	m.	PROPN
admet-1513	1515	11	hafner	hafner	PROPN
admet-1513	1515	12	,	,	PUNCT
admet-1513	1515	13	j.l	j.l	PROPN
admet-1513	1515	14	.	.	PROPN
admet-1513	1515	15	muhlich	muhlich	PROPN
admet-1513	1515	16	,	,	PUNCT
admet-1513	1515	17	e.m	e.m	PROPN
admet-1513	1515	18	.	.	PROPN
admet-1513	1515	19	gottwald	gottwald	PROPN
admet-1513	1515	20	,	,	PUNCT
admet-1513	1515	21	e.	e.	PROPN
admet-1513	1515	22	weber	weber	PROPN
admet-1513	1515	23	,	,	PUNCT
admet-1513	1515	24	a.	a.	PROPN
admet-1513	1515	25	jaklic	jaklic	PROPN
admet-1513	1515	26	,	,	PUNCT
admet-1513	1515	27	a.k	a.k	PROPN
admet-1513	1515	28	.	.	PROPN
admet-1513	1515	29	ajay	ajay	PROPN
admet-1513	1515	30	,	,	PUNCT
admet-1513	1515	31	d.	d.	PROPN
admet-1513	1515	32	svoboda	svoboda	PROPN
admet-1513	1515	33	,	,	PUNCT
admet-1513	1515	34	s.	s.	PROPN
admet-1513	1515	35	auerbach	auerbach	PROPN
admet-1513	1515	36	,	,	PUNCT
admet-1513	1515	37	e.j	e.j	PROPN
admet-1513	1515	38	.	.	PROPN
admet-1513	1515	39	kelly	kelly	PROPN
admet-1513	1515	40	,	,	PUNCT
admet-1513	1515	41	j.	j.	PROPN
admet-1513	1515	42	himmelfarb	himmelfarb	PROPN
admet-1513	1515	43	,	,	PUNCT
admet-1513	1515	44	v.s.	v.s.	PROPN
admet-1513	1515	45	vaidya	vaidya	PROPN
admet-1513	1515	46	.	.	PUNCT
admet-1513	1516	1	a	a	DET
admet-1513	1516	2	quantitative	quantitative	ADJ
admet-1513	1516	3	approach	approach	NOUN
admet-1513	1516	4	to	to	ADP
admet-1513	1516	5	screen	screen	NOUN
admet-1513	1516	6	for	for	ADP
admet-1513	1516	7	nephrotoxic	nephrotoxic	ADJ
admet-1513	1516	8	compounds	compound	NOUN
admet-1513	1516	9	in	in	ADP
admet-1513	1516	10	vitro	vitro	X
admet-1513	1516	11	.	.	PUNCT
admet-1513	1517	1	j.	j.	PROPN
admet-1513	1517	2	am	am	PROPN
admet-1513	1517	3	.	.	PUNCT
admet-1513	1518	1	soc	soc	PROPN
admet-1513	1518	2	.	.	PUNCT
admet-1513	1519	1	nephrol	nephrol	PROPN
admet-1513	1519	2	.	.	PUNCT
admet-1513	1520	1	27	27	NUM
admet-1513	1520	2	(	(	PUNCT
admet-1513	1520	3	2016	2016	NUM
admet-1513	1520	4	)	)	PUNCT
admet-1513	1520	5	1015	1015	NUM
admet-1513	1520	6	-	-	SYM
admet-1513	1520	7	1028	1028	NUM
admet-1513	1520	8	.	.	PUNCT
admet-1513	1521	1	https://doi.org/10.1681/asn.2015010060	https://doi.org/10.1681/asn.2015010060	NOUN
admet-1513	1521	2	.	.	PUNCT
admet-1513	1522	1	[	[	X
admet-1513	1522	2	193	193	NUM
admet-1513	1522	3	]	]	X
admet-1513	1522	4	t.m	t.m	PROPN
admet-1513	1522	5	.	.	PROPN
admet-1513	1522	6	desrochers	desrochers	PROPN
admet-1513	1522	7	,	,	PUNCT
admet-1513	1522	8	l.	l.	PROPN
admet-1513	1522	9	suter	suter	PROPN
admet-1513	1522	10	,	,	PUNCT
admet-1513	1522	11	a.	a.	PROPN
admet-1513	1522	12	roth	roth	PROPN
admet-1513	1522	13	,	,	PUNCT
admet-1513	1522	14	d.l	d.l	PROPN
admet-1513	1522	15	.	.	PROPN
admet-1513	1522	16	kaplan	kaplan	PROPN
admet-1513	1522	17	.	.	PROPN
admet-1513	1522	18	bioengineered	bioengineere	VERB
admet-1513	1522	19	3d	3d	PROPN
admet-1513	1522	20	human	human	ADJ
admet-1513	1522	21	kidney	kidney	NOUN
admet-1513	1522	22	tissue	tissue	NOUN
admet-1513	1522	23	,	,	PUNCT
admet-1513	1522	24	a	a	DET
admet-1513	1522	25	platform	platform	NOUN
admet-1513	1522	26	for	for	ADP
admet-1513	1522	27	the	the	DET
admet-1513	1522	28	determination	determination	NOUN
admet-1513	1522	29	of	of	ADP
admet-1513	1522	30	nephrotoxicity	nephrotoxicity	NOUN
admet-1513	1522	31	.	.	PUNCT
admet-1513	1523	1	plos	plos	PROPN
admet-1513	1523	2	one	one	NUM
admet-1513	1523	3	8	8	NUM
admet-1513	1523	4	(	(	PUNCT
admet-1513	1523	5	2013	2013	NUM
admet-1513	1523	6	)	)	PUNCT
admet-1513	1524	1	e59219	e59219	PROPN
admet-1513	1524	2	.	.	PUNCT
admet-1513	1525	1	https://doi.org/10.1371/journal.pone.0059219	https://doi.org/10.1371/journal.pone.0059219	ADJ
admet-1513	1525	2	.	.	PUNCT
admet-1513	1526	1	[	[	X
admet-1513	1526	2	194	194	NUM
admet-1513	1526	3	]	]	X
admet-1513	1526	4	b.s	b.s	PROPN
admet-1513	1526	5	.	.	PROPN
admet-1513	1526	6	freedman	freedman	PROPN
admet-1513	1526	7	,	,	PUNCT
admet-1513	1526	8	c.r	c.r	PROPN
admet-1513	1526	9	.	.	PROPN
admet-1513	1526	10	brooks	brooks	PROPN
admet-1513	1526	11	,	,	PUNCT
admet-1513	1526	12	a.q	a.q	PROPN
admet-1513	1526	13	.	.	PROPN
admet-1513	1526	14	lam	lam	PROPN
admet-1513	1526	15	,	,	PUNCT
admet-1513	1526	16	h.	h.	PROPN
admet-1513	1526	17	fu	fu	PROPN
admet-1513	1526	18	,	,	PUNCT
admet-1513	1526	19	r.	r.	PROPN
admet-1513	1526	20	morizane	morizane	PROPN
admet-1513	1526	21	,	,	PUNCT
admet-1513	1526	22	v.	v.	PROPN
admet-1513	1526	23	agrawal	agrawal	PROPN
admet-1513	1526	24	,	,	PUNCT
admet-1513	1526	25	a.f	a.f	PROPN
admet-1513	1526	26	.	.	PROPN
admet-1513	1527	1	saad	saad	PROPN
admet-1513	1527	2	,	,	PUNCT
admet-1513	1527	3	m.k	m.k	PROPN
admet-1513	1527	4	.	.	PUNCT
admet-1513	1527	5	li	li	PROPN
admet-1513	1527	6	,	,	PUNCT
admet-1513	1527	7	m.r	m.r	PROPN
admet-1513	1527	8	.	.	PROPN
admet-1513	1527	9	hughes	hughes	PROPN
admet-1513	1527	10	,	,	PUNCT
admet-1513	1527	11	r.v	r.v	PROPN
admet-1513	1527	12	.	.	PROPN
admet-1513	1527	13	werff	werff	NOUN
admet-1513	1527	14	,	,	PUNCT
admet-1513	1527	15	d.t	d.t	PROPN
admet-1513	1527	16	.	.	PROPN
admet-1513	1527	17	peters	peters	PROPN
admet-1513	1527	18	,	,	PUNCT
admet-1513	1527	19	j.	j.	PROPN
admet-1513	1527	20	lu	lu	PROPN
admet-1513	1527	21	,	,	PUNCT
admet-1513	1527	22	a.	a.	NOUN
admet-1513	1527	23	baccei	baccei	PROPN
admet-1513	1527	24	,	,	PUNCT
admet-1513	1527	25	a.m.	a.m.	PROPN
admet-1513	1527	26	siedlecki	siedlecki	PROPN
admet-1513	1527	27	,	,	PUNCT
admet-1513	1527	28	m.t	m.t	PROPN
admet-1513	1527	29	.	.	PROPN
admet-1513	1527	30	valerius	valerius	PROPN
admet-1513	1527	31	,	,	PUNCT
admet-1513	1527	32	k.	k.	PROPN
admet-1513	1527	33	musunuru	musunuru	PROPN
admet-1513	1527	34	,	,	PUNCT
admet-1513	1527	35	k.m	k.m	PROPN
admet-1513	1527	36	.	.	PROPN
admet-1513	1527	37	mcnagny	mcnagny	PROPN
admet-1513	1527	38	,	,	PUNCT
admet-1513	1527	39	t.i	t.i	PROPN
admet-1513	1527	40	.	.	PROPN
admet-1513	1527	41	steinman	steinman	PROPN
admet-1513	1527	42	,	,	PUNCT
admet-1513	1527	43	j.	j.	PROPN
admet-1513	1527	44	zhou	zhou	PROPN
admet-1513	1527	45	,	,	PUNCT
admet-1513	1527	46	p.h	p.h	PROPN
admet-1513	1527	47	.	.	PROPN
admet-1513	1527	48	lerou	lerou	PROPN
admet-1513	1527	49	,	,	PUNCT
admet-1513	1527	50	j.v	j.v	PROPN
admet-1513	1527	51	.	.	PROPN
admet-1513	1527	52	bonventre	bonventre	PROPN
admet-1513	1527	53	.	.	PUNCT
admet-1513	1528	1	modelling	model	VERB
admet-1513	1528	2	kidney	kidney	NOUN
admet-1513	1528	3	disease	disease	NOUN
admet-1513	1528	4	with	with	ADP
admet-1513	1528	5	crispr	crispr	ADJ
admet-1513	1528	6	-	-	PUNCT
admet-1513	1528	7	mutant	mutant	NOUN
admet-1513	1528	8	kidney	kidney	NOUN
admet-1513	1528	9	organoids	organoid	NOUN
admet-1513	1528	10	derived	derive	VERB
admet-1513	1528	11	from	from	ADP
admet-1513	1528	12	human	human	ADJ
admet-1513	1528	13	pluripotent	pluripotent	ADJ
admet-1513	1528	14	epiblast	epiblast	NOUN
admet-1513	1528	15	spheroids	spheroid	NOUN
admet-1513	1528	16	.	.	PUNCT
admet-1513	1529	1	nat	nat	PROPN
admet-1513	1529	2	.	.	PUNCT
admet-1513	1530	1	commun	commun	PROPN
admet-1513	1530	2	.	.	PROPN
admet-1513	1531	1	6	6	NUM
admet-1513	1531	2	(	(	PUNCT
admet-1513	1531	3	2015	2015	NUM
admet-1513	1531	4	)	)	PUNCT
admet-1513	1531	5	8715	8715	NUM
admet-1513	1531	6	.	.	PUNCT
admet-1513	1532	1	https://doi.org/10.1038/ncomms9715	https://doi.org/10.1038/ncomms9715	NOUN
admet-1513	1532	2	.	.	PUNCT
admet-1513	1533	1	[	[	X
admet-1513	1533	2	195	195	NUM
admet-1513	1533	3	]	]	X
admet-1513	1533	4	s.m	s.m	PROPN
admet-1513	1533	5	.	.	PROPN
admet-1513	1533	6	czerniecki	czerniecki	PROPN
admet-1513	1533	7	,	,	PUNCT
admet-1513	1533	8	n.m	n.m	PROPN
admet-1513	1533	9	.	.	PROPN
admet-1513	1533	10	cruz	cruz	PROPN
admet-1513	1533	11	,	,	PUNCT
admet-1513	1533	12	j.l	j.l	PROPN
admet-1513	1533	13	.	.	PROPN
admet-1513	1533	14	harder	hard	ADV
admet-1513	1533	15	,	,	PUNCT
admet-1513	1533	16	r.	r.	PROPN
admet-1513	1533	17	menon	menon	PROPN
admet-1513	1533	18	,	,	PUNCT
admet-1513	1533	19	j.	j.	PROPN
admet-1513	1533	20	annis	annis	PROPN
admet-1513	1533	21	,	,	PUNCT
admet-1513	1533	22	e.a	e.a	PROPN
admet-1513	1533	23	.	.	PROPN
admet-1513	1533	24	otto	otto	PROPN
admet-1513	1533	25	,	,	PUNCT
admet-1513	1533	26	r.e	r.e	PROPN
admet-1513	1533	27	.	.	PROPN
admet-1513	1533	28	gulieva	gulieva	PROPN
admet-1513	1533	29	,	,	PUNCT
admet-1513	1533	30	l.v	l.v	PROPN
admet-1513	1533	31	.	.	PROPN
admet-1513	1533	32	islas	islas	PROPN
admet-1513	1533	33	,	,	PUNCT
admet-1513	1533	34	y.k	y.k	PROPN
admet-1513	1533	35	.	.	PROPN
admet-1513	1533	36	kim	kim	PROPN
admet-1513	1533	37	,	,	PUNCT
admet-1513	1533	38	l.m	l.m	PROPN
admet-1513	1533	39	.	.	PROPN
admet-1513	1533	40	tran	tran	PROPN
admet-1513	1533	41	,	,	PUNCT
admet-1513	1533	42	t.j	t.j	PROPN
admet-1513	1533	43	.	.	PROPN
admet-1513	1533	44	martins	martins	PROPN
admet-1513	1533	45	,	,	PUNCT
admet-1513	1533	46	j.w	j.w	PROPN
admet-1513	1533	47	.	.	PROPN
admet-1513	1533	48	pippin	pippin	PROPN
admet-1513	1533	49	,	,	PUNCT
admet-1513	1533	50	h.	h.	PROPN
admet-1513	1533	51	fu	fu	PROPN
admet-1513	1533	52	,	,	PUNCT
admet-1513	1533	53	m.	m.	NOUN
admet-1513	1533	54	kretzler	kretzler	PROPN
admet-1513	1533	55	,	,	PUNCT
admet-1513	1533	56	s.j	s.j	PROPN
admet-1513	1533	57	.	.	PROPN
admet-1513	1533	58	shankland	shankland	PROPN
admet-1513	1533	59	,	,	PUNCT
admet-1513	1533	60	j.	j.	PROPN
admet-1513	1533	61	himmelfarb	himmelfarb	PROPN
admet-1513	1533	62	,	,	PUNCT
admet-1513	1533	63	r.t	r.t	PROPN
admet-1513	1533	64	.	.	PROPN
admet-1513	1533	65	moon	moon	PROPN
admet-1513	1533	66	,	,	PUNCT
admet-1513	1533	67	n.	n.	NOUN
admet-1513	1533	68	paragas	paragas	NOUN
admet-1513	1533	69	,	,	PUNCT
admet-1513	1533	70	b.s	b.s	PROPN
admet-1513	1533	71	.	.	PROPN
admet-1513	1533	72	freedman	freedman	PROPN
admet-1513	1533	73	.	.	PUNCT
admet-1513	1534	1	high	high	ADJ
admet-1513	1534	2	-	-	PUNCT
admet-1513	1534	3	throughput	throughput	NOUN
admet-1513	1534	4	screening	screening	NOUN
admet-1513	1534	5	enhances	enhance	VERB
admet-1513	1534	6	kidney	kidney	NOUN
admet-1513	1534	7	organoid	organoid	NOUN
admet-1513	1534	8	differentiation	differentiation	NOUN
admet-1513	1534	9	from	from	ADP
admet-1513	1534	10	human	human	ADJ
admet-1513	1534	11	pluripotent	pluripotent	NOUN
admet-1513	1534	12	stem	stem	NOUN
admet-1513	1534	13	cells	cell	NOUN
admet-1513	1534	14	and	and	CCONJ
admet-1513	1534	15	enables	enable	VERB
admet-1513	1534	16	automated	automate	VERB
admet-1513	1534	17	multidimensional	multidimensional	ADJ
admet-1513	1534	18	phenotyping	phenotyping	NOUN
admet-1513	1534	19	.	.	PUNCT
admet-1513	1535	1	cell	cell	NOUN
admet-1513	1535	2	stem	stem	NOUN
admet-1513	1535	3	cell	cell	NOUN
admet-1513	1535	4	22	22	NUM
admet-1513	1535	5	(	(	PUNCT
admet-1513	1535	6	2018	2018	NUM
admet-1513	1535	7	)	)	PUNCT
admet-1513	1535	8	929	929	NUM
admet-1513	1535	9	-	-	PUNCT
admet-1513	1535	10	940.e4	940.e4	NUM
admet-1513	1535	11	.	.	PUNCT
admet-1513	1536	1	https://doi.org/10.1016/j.stem.2018.04.022	https://doi.org/10.1016/j.stem.2018.04.022	NOUN
admet-1513	1536	2	.	.	PUNCT
admet-1513	1537	1	[	[	X
admet-1513	1537	2	196	196	NUM
admet-1513	1537	3	]	]	X
admet-1513	1537	4	s.m	s.m	PROPN
admet-1513	1537	5	.	.	PROPN
admet-1513	1537	6	king	king	PROPN
admet-1513	1537	7	,	,	PUNCT
admet-1513	1537	8	j.w	j.w	PROPN
admet-1513	1537	9	.	.	PROPN
admet-1513	1537	10	higgins	higgins	PROPN
admet-1513	1537	11	,	,	PUNCT
admet-1513	1537	12	c.r	c.r	PROPN
admet-1513	1537	13	.	.	PROPN
admet-1513	1537	14	nino	nino	PROPN
admet-1513	1537	15	,	,	PUNCT
admet-1513	1537	16	t.r	t.r	PROPN
admet-1513	1537	17	.	.	PROPN
admet-1513	1537	18	smith	smith	PROPN
admet-1513	1537	19	,	,	PUNCT
admet-1513	1537	20	e.h	e.h	PROPN
admet-1513	1537	21	.	.	PROPN
admet-1513	1537	22	paffenroth	paffenroth	PROPN
admet-1513	1537	23	,	,	PUNCT
admet-1513	1537	24	c.e	c.e	PROPN
admet-1513	1537	25	.	.	PROPN
admet-1513	1537	26	fairbairn	fairbairn	PROPN
admet-1513	1537	27	,	,	PUNCT
admet-1513	1537	28	a.	a.	PROPN
admet-1513	1537	29	docuyanan	docuyanan	PROPN
admet-1513	1537	30	,	,	PUNCT
admet-1513	1537	31	v.d	v.d	PROPN
admet-1513	1537	32	.	.	PROPN
admet-1513	1537	33	shah	shah	PROPN
admet-1513	1537	34	,	,	PUNCT
admet-1513	1537	35	a.e	a.e	PROPN
admet-1513	1537	36	.	.	PROPN
admet-1513	1537	37	chen	chen	PROPN
admet-1513	1537	38	,	,	PUNCT
admet-1513	1537	39	s.c	s.c	PROPN
admet-1513	1537	40	.	.	PROPN
admet-1513	1537	41	presnell	presnell	PROPN
admet-1513	1537	42	,	,	PUNCT
admet-1513	1537	43	d.g	d.g	PROPN
admet-1513	1537	44	.	.	PROPN
admet-1513	1537	45	nguyen	nguyen	NOUN
admet-1513	1537	46	.	.	PUNCT
admet-1513	1538	1	3d	3d	NUM
admet-1513	1538	2	proximal	proximal	ADJ
admet-1513	1538	3	tubule	tubule	NOUN
admet-1513	1538	4	tissues	tissue	NOUN
admet-1513	1538	5	recapitulate	recapitulate	VERB
admet-1513	1538	6	key	key	ADJ
admet-1513	1538	7	aspects	aspect	NOUN
admet-1513	1538	8	of	of	ADP
admet-1513	1538	9	renal	renal	ADJ
admet-1513	1538	10	physiology	physiology	NOUN
admet-1513	1538	11	to	to	PART
admet-1513	1538	12	enable	enable	VERB
admet-1513	1538	13	nephrotoxicity	nephrotoxicity	NOUN
admet-1513	1538	14	testing	testing	NOUN
admet-1513	1538	15	.	.	PUNCT
admet-1513	1539	1	front	front	ADJ
admet-1513	1539	2	.	.	PUNCT
admet-1513	1540	1	physiol	physiol	PROPN
admet-1513	1540	2	.	.	PUNCT
admet-1513	1541	1	8	8	NUM
admet-1513	1541	2	(	(	PUNCT
admet-1513	1541	3	2017	2017	NUM
admet-1513	1541	4	)	)	PUNCT
admet-1513	1541	5	123	123	NUM
admet-1513	1541	6	.	.	PUNCT
admet-1513	1542	1	https://doi.org/10.3389/fphys.2017.00123	https://doi.org/10.3389/fphys.2017.00123	NOUN
admet-1513	1542	2	.	.	PUNCT
admet-1513	1543	1	https://doi.org/10.1016/j.vascn.2020.106886	https://doi.org/10.1016/j.vascn.2020.106886	PROPN
admet-1513	1543	2	https://doi.org/10.1016/j.vascn.2020.106886	https://doi.org/10.1016/j.vascn.2020.106886	PROPN
admet-1513	1544	1	https://doi.org/10.1016/j.biomaterials.2018.02.024	https://doi.org/10.1016/j.biomaterials.2018.02.024	PROPN
admet-1513	1544	2	https://doi.org/10.1002/cpt.1385	https://doi.org/10.1002/cpt.1385	PROPN
admet-1513	1544	3	https://doi.org/10.1038/s41598-018-28393-y	https://doi.org/10.1038/s41598-018-28393-y	PROPN
admet-1513	1544	4	https://doi.org/10.1038/s41551-020-0539-4	https://doi.org/10.1038/s41551-020-0539-4	NUM
admet-1513	1545	1	https://doi.org/10.3389/fcell.2020.00178	https://doi.org/10.3389/fcell.2020.00178	PROPN
admet-1513	1545	2	https://doi.org/10.1016/j.pharmthera.2016.03.016	https://doi.org/10.1016/j.pharmthera.2016.03.016	PROPN
admet-1513	1545	3	https://doi.org/10.1038/s41581-018-0003-9	https://doi.org/10.1038/s41581-018-0003-9	NUM
admet-1513	1545	4	https://doi.org/10.1681/asn.2015010060	https://doi.org/10.1681/asn.2015010060	NOUN
admet-1513	1545	5	https://doi.org/10.1681/asn.2015010060	https://doi.org/10.1681/asn.2015010060	NOUN
admet-1513	1545	6	https://doi.org/10.1371/journal.pone.0059219	https://doi.org/10.1371/journal.pone.0059219	ADJ
admet-1513	1545	7	https://doi.org/10.1371/journal.pone.0059219	https://doi.org/10.1371/journal.pone.0059219	ADJ
admet-1513	1545	8	https://doi.org/10.1038/ncomms9715	https://doi.org/10.1038/ncomms9715	NOUN
admet-1513	1545	9	https://doi.org/10.1016/j.stem.2018.04.022	https://doi.org/10.1016/j.stem.2018.04.022	NOUN
admet-1513	1545	10	https://doi.org/10.3389/fphys.2017.00123	https://doi.org/10.3389/fphys.2017.00123	PROPN
admet-1513	1545	11	https://doi.org/10.3389/fphys.2017.00123	https://doi.org/10.3389/fphys.2017.00123	PROPN
admet-1513	1545	12	admet	admet	PROPN
admet-1513	1545	13	&	&	CCONJ
admet-1513	1545	14	dmpk	dmpk	PROPN
admet-1513	1545	15	11(1	11(1	NUM
admet-1513	1545	16	)	)	PUNCT
admet-1513	1545	17	(	(	PUNCT
admet-1513	1545	18	2023	2023	NUM
admet-1513	1545	19	)	)	PUNCT
admet-1513	1545	20	1	1	NUM
admet-1513	1545	21	-	-	SYM
admet-1513	1545	22	32	32	NUM
admet-1513	1545	23	2d	2d	NOUN
admet-1513	1545	24	and	and	CCONJ
admet-1513	1545	25	3d	3d	NOUN
admet-1513	1545	26	adme	adme	PROPN
admet-1513	1545	27	-	-	PUNCT
admet-1513	1545	28	tox	tox	NOUN
admet-1513	1545	29	cell	cell	NOUN
admet-1513	1545	30	culture	culture	NOUN
admet-1513	1545	31	screening	screen	VERB
admet-1513	1545	32	:	:	PUNCT
admet-1513	1545	33	a	a	DET
admet-1513	1545	34	review	review	NOUN
admet-1513	1545	35	doi	doi	NOUN
admet-1513	1545	36	:	:	PUNCT
admet-1513	1545	37	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	NOUN
admet-1513	1545	38	31	31	NUM
admet-1513	1545	39	[	[	X
admet-1513	1545	40	197	197	NUM
admet-1513	1545	41	]	]	X
admet-1513	1545	42	a.l	a.l	PROPN
admet-1513	1545	43	.	.	PROPN
admet-1513	1545	44	walker	walker	PROPN
admet-1513	1545	45	,	,	PUNCT
admet-1513	1545	46	s.z	s.z	PROPN
admet-1513	1545	47	.	.	PROPN
admet-1513	1545	48	imam	imam	PROPN
admet-1513	1545	49	,	,	PUNCT
admet-1513	1545	50	r.a	r.a	PROPN
admet-1513	1545	51	.	.	PROPN
admet-1513	1545	52	roberts	roberts	PROPN
admet-1513	1545	53	.	.	PUNCT
admet-1513	1545	54	drug	drug	NOUN
admet-1513	1545	55	discovery	discovery	PROPN
admet-1513	1545	56	and	and	CCONJ
admet-1513	1545	57	development	development	NOUN
admet-1513	1545	58	:	:	PUNCT
admet-1513	1545	59	biomarkers	biomarker	NOUN
admet-1513	1545	60	of	of	ADP
admet-1513	1545	61	neurotoxicity	neurotoxicity	NOUN
admet-1513	1545	62	and	and	CCONJ
admet-1513	1545	63	neurodegeneration	neurodegeneration	NOUN
admet-1513	1545	64	.	.	PUNCT
admet-1513	1546	1	exp	exp	NOUN
admet-1513	1546	2	.	.	PUNCT
admet-1513	1547	1	biol	biol	PROPN
admet-1513	1547	2	.	.	PUNCT
admet-1513	1548	1	med	med	PROPN
admet-1513	1548	2	.	.	PUNCT
admet-1513	1549	1	(	(	PUNCT
admet-1513	1549	2	maywood	maywood	PROPN
admet-1513	1549	3	)	)	PUNCT
admet-1513	1549	4	243	243	NUM
admet-1513	1549	5	(	(	PUNCT
admet-1513	1549	6	2018	2018	NUM
admet-1513	1549	7	)	)	PUNCT
admet-1513	1549	8	1037	1037	NUM
admet-1513	1549	9	-	-	SYM
admet-1513	1549	10	1045	1045	NUM
admet-1513	1549	11	.	.	PUNCT
admet-1513	1550	1	https://doi.org/10.1177/1535370218801309	https://doi.org/10.1177/1535370218801309	NOUN
admet-1513	1550	2	.	.	PUNCT
admet-1513	1551	1	[	[	X
admet-1513	1551	2	198	198	NUM
admet-1513	1551	3	]	]	X
admet-1513	1551	4	m.s	m.s	PROPN
admet-1513	1551	5	.	.	PROPN
admet-1513	1551	6	wilson	wilson	PROPN
admet-1513	1551	7	,	,	PUNCT
admet-1513	1551	8	j.r	j.r	PROPN
admet-1513	1551	9	.	.	PROPN
admet-1513	1551	10	graham	graham	PROPN
admet-1513	1551	11	,	,	PUNCT
admet-1513	1551	12	a.j	a.j	PROPN
admet-1513	1551	13	.	.	PROPN
admet-1513	1551	14	ball	ball	PROPN
admet-1513	1551	15	.	.	PUNCT
admet-1513	1552	1	multiparametric	multiparametric	PROPN
admet-1513	1552	2	high	high	ADJ
admet-1513	1552	3	content	content	NOUN
admet-1513	1552	4	analysis	analysis	NOUN
admet-1513	1552	5	for	for	ADP
admet-1513	1552	6	assessment	assessment	NOUN
admet-1513	1552	7	of	of	ADP
admet-1513	1552	8	neurotoxicity	neurotoxicity	NOUN
admet-1513	1552	9	in	in	ADP
admet-1513	1552	10	differentiated	differentiated	ADJ
admet-1513	1552	11	neuronal	neuronal	ADJ
admet-1513	1552	12	cell	cell	NOUN
admet-1513	1552	13	lines	line	NOUN
admet-1513	1552	14	and	and	CCONJ
admet-1513	1552	15	human	human	ADJ
admet-1513	1552	16	embryonic	embryonic	ADJ
admet-1513	1552	17	stem	stem	NOUN
admet-1513	1552	18	cell	cell	NOUN
admet-1513	1552	19	-	-	PUNCT
admet-1513	1552	20	derived	derive	VERB
admet-1513	1552	21	neurons	neuron	NOUN
admet-1513	1552	22	.	.	PUNCT
admet-1513	1553	1	neurotoxicology	neurotoxicology	NOUN
admet-1513	1553	2	42	42	NUM
admet-1513	1553	3	(	(	PUNCT
admet-1513	1553	4	2014	2014	NUM
admet-1513	1553	5	)	)	PUNCT
admet-1513	1553	6	33	33	NUM
admet-1513	1553	7	-	-	SYM
admet-1513	1553	8	48	48	NUM
admet-1513	1553	9	.	.	PUNCT
admet-1513	1554	1	https://doi.org/10.1016/j.neuro.2014.03.013	https://doi.org/10.1016/j.neuro.2014.03.013	NOUN
admet-1513	1554	2	.	.	PUNCT
admet-1513	1555	1	[	[	X
admet-1513	1555	2	199	199	NUM
admet-1513	1555	3	]	]	X
admet-1513	1555	4	k.n	k.n	PROPN
admet-1513	1555	5	.	.	PROPN
admet-1513	1555	6	bitar	bitar	PROPN
admet-1513	1555	7	,	,	PUNCT
admet-1513	1555	8	e.	e.	PROPN
admet-1513	1555	9	zakhem	zakhem	PROPN
admet-1513	1555	10	.	.	PUNCT
admet-1513	1556	1	bioengineering	bioengineere	VERB
admet-1513	1556	2	the	the	DET
admet-1513	1556	3	gut	gut	NOUN
admet-1513	1556	4	:	:	PUNCT
admet-1513	1556	5	future	future	ADJ
admet-1513	1556	6	prospects	prospect	NOUN
admet-1513	1556	7	of	of	ADP
admet-1513	1556	8	regenerative	regenerative	ADJ
admet-1513	1556	9	medicine	medicine	NOUN
admet-1513	1556	10	.	.	PUNCT
admet-1513	1557	1	nat	nat	PROPN
admet-1513	1557	2	.	.	PUNCT
admet-1513	1558	1	rev	rev	PROPN
admet-1513	1558	2	.	.	PROPN
admet-1513	1558	3	gastroenterol	gastroenterol	PROPN
admet-1513	1558	4	.	.	PUNCT
admet-1513	1559	1	hepatol	hepatol	ADJ
admet-1513	1559	2	.	.	PUNCT
admet-1513	1560	1	13	13	NUM
admet-1513	1560	2	(	(	PUNCT
admet-1513	1560	3	2016	2016	NUM
admet-1513	1560	4	)	)	PUNCT
admet-1513	1560	5	543	543	NUM
admet-1513	1560	6	-	-	SYM
admet-1513	1560	7	556	556	NUM
admet-1513	1560	8	.	.	PUNCT
admet-1513	1561	1	https://doi.org/10.1038/nrgastro.2016.124	https://doi.org/10.1038/nrgastro.2016.124	NOUN
admet-1513	1561	2	.	.	PUNCT
admet-1513	1562	1	[	[	X
admet-1513	1562	2	200	200	NUM
admet-1513	1562	3	]	]	X
admet-1513	1562	4	y.	y.	PROPN
admet-1513	1562	5	takahashi	takahashi	PROPN
admet-1513	1562	6	,	,	PUNCT
admet-1513	1562	7	s.	s.	PROPN
admet-1513	1562	8	sato	sato	PROPN
admet-1513	1562	9	,	,	PUNCT
admet-1513	1562	10	y.	y.	PROPN
admet-1513	1562	11	kurashima	kurashima	PROPN
admet-1513	1562	12	,	,	PUNCT
admet-1513	1562	13	t.	t.	PROPN
admet-1513	1562	14	yamamoto	yamamoto	PROPN
admet-1513	1562	15	,	,	PUNCT
admet-1513	1562	16	s.	s.	PROPN
admet-1513	1562	17	kurokawa	kurokawa	PROPN
admet-1513	1562	18	,	,	PUNCT
admet-1513	1562	19	y.	y.	PROPN
admet-1513	1562	20	yuki	yuki	PROPN
admet-1513	1562	21	,	,	PUNCT
admet-1513	1562	22	n.	n.	PROPN
admet-1513	1562	23	takemura	takemura	PROPN
admet-1513	1562	24	,	,	PUNCT
admet-1513	1562	25	s.	s.	PROPN
admet-1513	1562	26	uematsu	uematsu	PROPN
admet-1513	1562	27	,	,	PUNCT
admet-1513	1562	28	c.y	c.y	PROPN
admet-1513	1562	29	.	.	PROPN
admet-1513	1562	30	lai	lai	PROPN
admet-1513	1562	31	,	,	PUNCT
admet-1513	1562	32	m.	m.	NOUN
admet-1513	1562	33	otsu	otsu	PROPN
admet-1513	1562	34	,	,	PUNCT
admet-1513	1562	35	h.	h.	PROPN
admet-1513	1562	36	matsuno	matsuno	PROPN
admet-1513	1562	37	,	,	PUNCT
admet-1513	1562	38	h.	h.	PROPN
admet-1513	1562	39	osawa	osawa	PROPN
admet-1513	1562	40	,	,	PUNCT
admet-1513	1562	41	t.	t.	PROPN
admet-1513	1562	42	mizushima	mizushima	PROPN
admet-1513	1562	43	,	,	PUNCT
admet-1513	1562	44	j.	j.	PROPN
admet-1513	1562	45	nishimura	nishimura	PROPN
admet-1513	1562	46	,	,	PUNCT
admet-1513	1562	47	m.	m.	PROPN
admet-1513	1562	48	hayashi	hayashi	PROPN
admet-1513	1562	49	,	,	PUNCT
admet-1513	1562	50	t.	t.	PROPN
admet-1513	1562	51	yamaguchi	yamaguchi	PROPN
admet-1513	1562	52	,	,	PUNCT
admet-1513	1562	53	h.	h.	PROPN
admet-1513	1562	54	kiyono	kiyono	PROPN
admet-1513	1562	55	.	.	PUNCT
admet-1513	1563	1	a	a	DET
admet-1513	1563	2	refined	refined	ADJ
admet-1513	1563	3	culture	culture	NOUN
admet-1513	1563	4	system	system	NOUN
admet-1513	1563	5	for	for	ADP
admet-1513	1563	6	human	human	ADJ
admet-1513	1563	7	induced	induced	ADJ
admet-1513	1563	8	pluripotent	pluripotent	NOUN
admet-1513	1563	9	stem	stem	NOUN
admet-1513	1563	10	cell	cell	NOUN
admet-1513	1563	11	-	-	PUNCT
admet-1513	1563	12	derived	derive	VERB
admet-1513	1563	13	intestinal	intestinal	ADJ
admet-1513	1563	14	epithelial	epithelial	ADJ
admet-1513	1563	15	organoids	organoid	NOUN
admet-1513	1563	16	.	.	PUNCT
admet-1513	1564	1	stem	stem	NOUN
admet-1513	1564	2	cell	cell	NOUN
admet-1513	1564	3	reports	report	NOUN
admet-1513	1564	4	10	10	NUM
admet-1513	1564	5	(	(	PUNCT
admet-1513	1564	6	2018	2018	NUM
admet-1513	1564	7	)	)	PUNCT
admet-1513	1564	8	314	314	NUM
admet-1513	1564	9	-	-	SYM
admet-1513	1564	10	328	328	NUM
admet-1513	1564	11	.	.	PUNCT
admet-1513	1565	1	https://doi.org/10.1016/j.stemcr.2017.11.004	https://doi.org/10.1016/j.stemcr.2017.11.004	X
admet-1513	1565	2	.	.	PUNCT
admet-1513	1566	1	[	[	X
admet-1513	1566	2	201	201	NUM
admet-1513	1566	3	]	]	PUNCT
admet-1513	1566	4	t.	t.	NOUN
admet-1513	1566	5	shirakawa	shirakawa	PROPN
admet-1513	1566	6	,	,	PUNCT
admet-1513	1566	7	i.	i.	PROPN
admet-1513	1566	8	suzuki	suzuki	PROPN
admet-1513	1566	9	.	.	PUNCT
admet-1513	1567	1	evaluation	evaluation	NOUN
admet-1513	1567	2	methods	method	NOUN
admet-1513	1567	3	for	for	ADP
admet-1513	1567	4	drug	drug	NOUN
admet-1513	1567	5	-	-	PUNCT
admet-1513	1567	6	induced	induce	VERB
admet-1513	1567	7	seizure	seizure	NOUN
admet-1513	1567	8	by	by	ADP
admet-1513	1567	9	microelectrode	microelectrode	PROPN
admet-1513	1567	10	array	array	NOUN
admet-1513	1567	11	recording	recording	NOUN
admet-1513	1567	12	using	use	VERB
admet-1513	1567	13	human	human	ADJ
admet-1513	1567	14	ips	ip	NOUN
admet-1513	1567	15	cell	cell	NOUN
admet-1513	1567	16	-	-	PUNCT
admet-1513	1567	17	derived	derive	VERB
admet-1513	1567	18	neurons	neuron	NOUN
admet-1513	1567	19	.	.	PUNCT
admet-1513	1568	1	nihon	nihon	PROPN
admet-1513	1568	2	yakurigaku	yakurigaku	PROPN
admet-1513	1568	3	zasshi	zasshi	PROPN
admet-1513	1568	4	155	155	NUM
admet-1513	1568	5	(	(	PUNCT
admet-1513	1568	6	2020	2020	NUM
admet-1513	1568	7	)	)	PUNCT
admet-1513	1568	8	284	284	NUM
admet-1513	1568	9	-	-	SYM
admet-1513	1568	10	288	288	NUM
admet-1513	1568	11	.	.	PUNCT
admet-1513	1569	1	https://doi.org/10.1254/fpj.20028	https://doi.org/10.1254/fpj.20028	ADV
admet-1513	1569	2	.	.	PUNCT
admet-1513	1570	1	[	[	X
admet-1513	1570	2	202	202	NUM
admet-1513	1570	3	]	]	X
admet-1513	1570	4	m.a	m.a	PROPN
admet-1513	1570	5	.	.	PROPN
admet-1513	1570	6	lancaster	lancaster	PROPN
admet-1513	1570	7	,	,	PUNCT
admet-1513	1570	8	m.	m.	NOUN
admet-1513	1570	9	renner	renner	PROPN
admet-1513	1570	10	,	,	PUNCT
admet-1513	1570	11	c.a	c.a	PROPN
admet-1513	1570	12	.	.	PROPN
admet-1513	1570	13	martin	martin	PROPN
admet-1513	1570	14	,	,	PUNCT
admet-1513	1570	15	d.	d.	PROPN
admet-1513	1570	16	wenzel	wenzel	PROPN
admet-1513	1570	17	,	,	PUNCT
admet-1513	1570	18	l.s	l.s	PROPN
admet-1513	1570	19	.	.	PROPN
admet-1513	1570	20	bicknell	bicknell	PROPN
admet-1513	1570	21	,	,	PUNCT
admet-1513	1570	22	m.e	m.e	PROPN
admet-1513	1570	23	.	.	PROPN
admet-1513	1570	24	hurles	hurle	NOUN
admet-1513	1570	25	,	,	PUNCT
admet-1513	1570	26	t.	t.	PROPN
admet-1513	1570	27	homfray	homfray	PROPN
admet-1513	1570	28	,	,	PUNCT
admet-1513	1570	29	j.m	j.m	PROPN
admet-1513	1570	30	.	.	PROPN
admet-1513	1570	31	penninger	penninger	PROPN
admet-1513	1570	32	,	,	PUNCT
admet-1513	1570	33	a.p	a.p	PROPN
admet-1513	1570	34	.	.	PROPN
admet-1513	1570	35	jackson	jackson	PROPN
admet-1513	1570	36	,	,	PUNCT
admet-1513	1570	37	j.a	j.a	PROPN
admet-1513	1570	38	.	.	PROPN
admet-1513	1570	39	knoblich	knoblich	PROPN
admet-1513	1570	40	.	.	PUNCT
admet-1513	1571	1	cerebral	cerebral	ADJ
admet-1513	1571	2	organoids	organoid	NOUN
admet-1513	1571	3	model	model	VERB
admet-1513	1571	4	human	human	ADJ
admet-1513	1571	5	brain	brain	PROPN
admet-1513	1571	6	development	development	NOUN
admet-1513	1571	7	and	and	CCONJ
admet-1513	1571	8	microcephaly	microcephaly	NOUN
admet-1513	1571	9	.	.	PUNCT
admet-1513	1572	1	nature	nature	NOUN
admet-1513	1572	2	501	501	NUM
admet-1513	1572	3	(	(	PUNCT
admet-1513	1572	4	2013	2013	NUM
admet-1513	1572	5	)	)	PUNCT
admet-1513	1572	6	373	373	NUM
admet-1513	1572	7	-	-	SYM
admet-1513	1572	8	379	379	NUM
admet-1513	1572	9	.	.	PUNCT
admet-1513	1573	1	https://doi.org/10.1038/nature12517	https://doi.org/10.1038/nature12517	PROPN
admet-1513	1573	2	.	.	PUNCT
admet-1513	1574	1	[	[	X
admet-1513	1574	2	203	203	NUM
admet-1513	1574	3	]	]	PUNCT
admet-1513	1574	4	t.	t.	NOUN
admet-1513	1574	5	chhibber	chhibber	PROPN
admet-1513	1574	6	,	,	PUNCT
admet-1513	1574	7	s.	s.	PROPN
admet-1513	1574	8	bagchi	bagchi	PROPN
admet-1513	1574	9	,	,	PUNCT
admet-1513	1574	10	b.	b.	PROPN
admet-1513	1574	11	lahooti	lahooti	PROPN
admet-1513	1574	12	,	,	PUNCT
admet-1513	1574	13	a.	a.	PROPN
admet-1513	1574	14	verma	verma	PROPN
admet-1513	1574	15	,	,	PUNCT
admet-1513	1574	16	a.	a.	PROPN
admet-1513	1574	17	al	al	PROPN
admet-1513	1574	18	-	-	PUNCT
admet-1513	1574	19	ahmad	ahmad	PROPN
admet-1513	1574	20	,	,	PUNCT
admet-1513	1574	21	m.k	m.k	PROPN
admet-1513	1574	22	.	.	PROPN
admet-1513	1574	23	paul	paul	PROPN
admet-1513	1574	24	,	,	PUNCT
admet-1513	1574	25	g.	g.	PROPN
admet-1513	1574	26	pendyala	pendyala	PROPN
admet-1513	1574	27	,	,	PUNCT
admet-1513	1574	28	r.d	r.d	PROPN
admet-1513	1574	29	.	.	PROPN
admet-1513	1574	30	jayant	jayant	PROPN
admet-1513	1574	31	.	.	PUNCT
admet-1513	1575	1	cns	cns	PROPN
admet-1513	1575	2	organoids	organoid	NOUN
admet-1513	1575	3	:	:	PUNCT
admet-1513	1575	4	an	an	DET
admet-1513	1575	5	innovative	innovative	ADJ
admet-1513	1575	6	tool	tool	NOUN
admet-1513	1575	7	for	for	ADP
admet-1513	1575	8	neurological	neurological	ADJ
admet-1513	1575	9	disease	disease	NOUN
admet-1513	1575	10	modeling	modeling	NOUN
admet-1513	1575	11	and	and	CCONJ
admet-1513	1575	12	drug	drug	NOUN
admet-1513	1575	13	neurotoxicity	neurotoxicity	NOUN
admet-1513	1575	14	screening	screening	NOUN
admet-1513	1575	15	.	.	PUNCT
admet-1513	1576	1	drug	drug	NOUN
admet-1513	1576	2	discov	discov	NOUN
admet-1513	1576	3	.	.	PUNCT
admet-1513	1577	1	today	today	NOUN
admet-1513	1577	2	25	25	NUM
admet-1513	1577	3	(	(	PUNCT
admet-1513	1577	4	2020	2020	NUM
admet-1513	1577	5	)	)	PUNCT
admet-1513	1577	6	456	456	NUM
admet-1513	1577	7	-	-	SYM
admet-1513	1577	8	465	465	NUM
admet-1513	1577	9	.	.	PUNCT
admet-1513	1578	1	https://doi.org/10.1016/j.drudis.2019.11.010	https://doi.org/10.1016/j.drudis.2019.11.010	NOUN
admet-1513	1578	2	.	.	PUNCT
admet-1513	1579	1	[	[	X
admet-1513	1579	2	204	204	NUM
admet-1513	1579	3	]	]	PUNCT
admet-1513	1579	4	a.m.	a.m.	NOUN
admet-1513	1579	5	paşca	paşca	PROPN
admet-1513	1579	6	,	,	PUNCT
admet-1513	1579	7	s.a	s.a	PROPN
admet-1513	1579	8	.	.	PROPN
admet-1513	1579	9	sloan	sloan	PROPN
admet-1513	1579	10	,	,	PUNCT
admet-1513	1579	11	l.e	l.e	PROPN
admet-1513	1579	12	.	.	PROPN
admet-1513	1579	13	clarke	clarke	PROPN
admet-1513	1579	14	,	,	PUNCT
admet-1513	1579	15	y.	y.	PROPN
admet-1513	1579	16	tian	tian	PROPN
admet-1513	1579	17	,	,	PUNCT
admet-1513	1579	18	c.d	c.d	PROPN
admet-1513	1579	19	.	.	PROPN
admet-1513	1579	20	makinson	makinson	PROPN
admet-1513	1579	21	,	,	PUNCT
admet-1513	1579	22	n.	n.	PROPN
admet-1513	1579	23	huber	huber	PROPN
admet-1513	1579	24	,	,	PUNCT
admet-1513	1579	25	c.h	c.h	PROPN
admet-1513	1580	1	.	.	PROPN
admet-1513	1580	2	kim	kim	PROPN
admet-1513	1580	3	,	,	PUNCT
admet-1513	1580	4	j.y	j.y	PROPN
admet-1513	1580	5	.	.	PROPN
admet-1513	1580	6	park	park	PROPN
admet-1513	1580	7	,	,	PUNCT
admet-1513	1580	8	n.a	n.a	PROPN
admet-1513	1580	9	.	.	PROPN
admet-1513	1580	10	o'rourke	o'rourke	PROPN
admet-1513	1580	11	,	,	PUNCT
admet-1513	1580	12	k.d	k.d	PROPN
admet-1513	1580	13	.	.	PROPN
admet-1513	1580	14	nguyen	nguyen	PROPN
admet-1513	1580	15	,	,	PUNCT
admet-1513	1580	16	s.j	s.j	PROPN
admet-1513	1580	17	.	.	PROPN
admet-1513	1580	18	smith	smith	PROPN
admet-1513	1580	19	,	,	PUNCT
admet-1513	1580	20	j.r	j.r	PROPN
admet-1513	1580	21	.	.	PROPN
admet-1513	1580	22	huguenard	huguenard	PROPN
admet-1513	1580	23	,	,	PUNCT
admet-1513	1580	24	d.h	d.h	PROPN
admet-1513	1580	25	.	.	PROPN
admet-1513	1580	26	geschwind	geschwind	PROPN
admet-1513	1580	27	,	,	PUNCT
admet-1513	1580	28	b.a	b.a	PROPN
admet-1513	1580	29	.	.	PROPN
admet-1513	1580	30	barres	barres	PROPN
admet-1513	1580	31	,	,	PUNCT
admet-1513	1580	32	s.p	s.p	PROPN
admet-1513	1580	33	.	.	PROPN
admet-1513	1580	34	paşca	paşca	PROPN
admet-1513	1580	35	.	.	PUNCT
admet-1513	1581	1	functional	functional	ADJ
admet-1513	1581	2	cortical	cortical	ADJ
admet-1513	1581	3	neurons	neuron	NOUN
admet-1513	1581	4	and	and	CCONJ
admet-1513	1581	5	astrocytes	astrocyte	NOUN
admet-1513	1581	6	from	from	ADP
admet-1513	1581	7	human	human	ADJ
admet-1513	1581	8	pluripotent	pluripotent	NOUN
admet-1513	1581	9	stem	stem	NOUN
admet-1513	1581	10	cells	cell	NOUN
admet-1513	1581	11	in	in	ADP
admet-1513	1581	12	3d	3d	PROPN
admet-1513	1581	13	culture	culture	NOUN
admet-1513	1581	14	.	.	PUNCT
admet-1513	1582	1	nat	nat	PROPN
admet-1513	1582	2	.	.	PUNCT
admet-1513	1583	1	methods	method	NOUN
admet-1513	1583	2	12	12	NUM
admet-1513	1583	3	(	(	PUNCT
admet-1513	1583	4	2015	2015	NUM
admet-1513	1583	5	)	)	PUNCT
admet-1513	1583	6	671	671	NUM
admet-1513	1583	7	-	-	SYM
admet-1513	1583	8	678	678	NUM
admet-1513	1583	9	.	.	PUNCT
admet-1513	1584	1	https://doi.org/10.1038/nmeth.3415	https://doi.org/10.1038/nmeth.3415	NOUN
admet-1513	1584	2	.	.	PUNCT
admet-1513	1585	1	[	[	X
admet-1513	1585	2	205	205	NUM
admet-1513	1585	3	]	]	X
admet-1513	1585	4	h.	h.	PROPN
admet-1513	1585	5	sakaguchi	sakaguchi	PROPN
admet-1513	1585	6	,	,	PUNCT
admet-1513	1585	7	t.	t.	PROPN
admet-1513	1585	8	kadoshima	kadoshima	PROPN
admet-1513	1585	9	,	,	PUNCT
admet-1513	1585	10	m.	m.	PROPN
admet-1513	1585	11	soen	soen	PROPN
admet-1513	1585	12	,	,	PUNCT
admet-1513	1585	13	n.	n.	PROPN
admet-1513	1585	14	narii	narii	PROPN
admet-1513	1585	15	,	,	PUNCT
admet-1513	1585	16	y.	y.	PROPN
admet-1513	1585	17	ishida	ishida	PROPN
admet-1513	1585	18	,	,	PUNCT
admet-1513	1585	19	m.	m.	NOUN
admet-1513	1585	20	ohgushi	ohgushi	PROPN
admet-1513	1585	21	,	,	PUNCT
admet-1513	1585	22	j.	j.	PROPN
admet-1513	1585	23	takahashi	takahashi	PROPN
admet-1513	1585	24	,	,	PUNCT
admet-1513	1585	25	m.	m.	NOUN
admet-1513	1585	26	eiraku	eiraku	PROPN
admet-1513	1585	27	,	,	PUNCT
admet-1513	1585	28	y.	y.	PROPN
admet-1513	1585	29	sasai	sasai	PROPN
admet-1513	1585	30	.	.	PUNCT
admet-1513	1586	1	generation	generation	NOUN
admet-1513	1586	2	of	of	ADP
admet-1513	1586	3	functional	functional	ADJ
admet-1513	1586	4	hippocampal	hippocampal	ADJ
admet-1513	1586	5	neurons	neuron	NOUN
admet-1513	1586	6	from	from	ADP
admet-1513	1586	7	self	self	NOUN
admet-1513	1586	8	-	-	PUNCT
admet-1513	1586	9	organizing	organize	VERB
admet-1513	1586	10	human	human	ADJ
admet-1513	1586	11	embryonic	embryonic	ADJ
admet-1513	1586	12	stem	stem	NOUN
admet-1513	1586	13	cellderived	cellderive	VERB
admet-1513	1586	14	dorsomedial	dorsomedial	ADJ
admet-1513	1586	15	telencephalic	telencephalic	NOUN
admet-1513	1586	16	tissue	tissue	NOUN
admet-1513	1586	17	.	.	PUNCT
admet-1513	1587	1	nat	nat	PROPN
admet-1513	1587	2	.	.	PUNCT
admet-1513	1588	1	commun	commun	PROPN
admet-1513	1588	2	.	.	PROPN
admet-1513	1589	1	6	6	NUM
admet-1513	1589	2	(	(	PUNCT
admet-1513	1589	3	2015	2015	NUM
admet-1513	1589	4	)	)	PUNCT
admet-1513	1589	5	8896	8896	NUM
admet-1513	1589	6	.	.	PUNCT
admet-1513	1590	1	https://doi.org/10.1038/ncomms9896	https://doi.org/10.1038/ncomms9896	PROPN
admet-1513	1590	2	.	.	PUNCT
admet-1513	1591	1	[	[	X
admet-1513	1591	2	206	206	NUM
admet-1513	1591	3	]	]	PUNCT
admet-1513	1592	1	k.	k.	PROPN
admet-1513	1592	2	muguruma	muguruma	PROPN
admet-1513	1592	3	,	,	PUNCT
admet-1513	1592	4	a.	a.	NOUN
admet-1513	1592	5	nishiyama	nishiyama	PROPN
admet-1513	1592	6	,	,	PUNCT
admet-1513	1592	7	h.	h.	PROPN
admet-1513	1592	8	kawakami	kawakami	PROPN
admet-1513	1592	9	,	,	PUNCT
admet-1513	1592	10	k.	k.	PROPN
admet-1513	1592	11	hashimoto	hashimoto	PROPN
admet-1513	1592	12	,	,	PUNCT
admet-1513	1592	13	y.	y.	PROPN
admet-1513	1592	14	sasai	sasai	PROPN
admet-1513	1592	15	.	.	PUNCT
admet-1513	1593	1	self	self	NOUN
admet-1513	1593	2	-	-	PUNCT
admet-1513	1593	3	organization	organization	NOUN
admet-1513	1593	4	of	of	ADP
admet-1513	1593	5	polarized	polarize	VERB
admet-1513	1593	6	cerebellar	cerebellar	ADJ
admet-1513	1593	7	tissue	tissue	NOUN
admet-1513	1593	8	in	in	ADP
admet-1513	1593	9	3d	3d	PROPN
admet-1513	1593	10	culture	culture	NOUN
admet-1513	1593	11	of	of	ADP
admet-1513	1593	12	human	human	ADJ
admet-1513	1593	13	pluripotent	pluripotent	ADJ
admet-1513	1593	14	stem	stem	NOUN
admet-1513	1593	15	cells	cell	NOUN
admet-1513	1593	16	.	.	PUNCT
admet-1513	1594	1	cell	cell	NOUN
admet-1513	1594	2	rep	rep	PROPN
admet-1513	1594	3	.	.	PROPN
admet-1513	1594	4	10	10	NUM
admet-1513	1594	5	(	(	PUNCT
admet-1513	1594	6	2015	2015	NUM
admet-1513	1594	7	)	)	PUNCT
admet-1513	1594	8	537	537	NUM
admet-1513	1594	9	-	-	SYM
admet-1513	1594	10	550	550	NUM
admet-1513	1594	11	.	.	PUNCT
admet-1513	1595	1	https://doi.org/10.1016/j.celrep.2014.12.051	https://doi.org/10.1016/j.celrep.2014.12.051	PROPN
admet-1513	1595	2	.	.	PUNCT
admet-1513	1596	1	[	[	X
admet-1513	1596	2	207	207	NUM
admet-1513	1596	3	]	]	PUNCT
admet-1513	1596	4	x.	x.	NOUN
admet-1513	1596	5	qian	qian	PROPN
admet-1513	1596	6	,	,	PUNCT
admet-1513	1596	7	h.n	h.n	PROPN
admet-1513	1596	8	.	.	PROPN
admet-1513	1596	9	nguyen	nguyen	PROPN
admet-1513	1596	10	,	,	PUNCT
admet-1513	1596	11	m.m	m.m	PROPN
admet-1513	1596	12	.	.	PROPN
admet-1513	1596	13	song	song	PROPN
admet-1513	1596	14	,	,	PUNCT
admet-1513	1596	15	c.	c.	PROPN
admet-1513	1596	16	hadiono	hadiono	PROPN
admet-1513	1596	17	,	,	PUNCT
admet-1513	1596	18	s.c	s.c	PROPN
admet-1513	1596	19	.	.	PROPN
admet-1513	1596	20	ogden	ogden	PROPN
admet-1513	1596	21	,	,	PUNCT
admet-1513	1596	22	c.	c.	PROPN
admet-1513	1596	23	hammack	hammack	PROPN
admet-1513	1596	24	,	,	PUNCT
admet-1513	1596	25	b.	b.	PROPN
admet-1513	1596	26	yao	yao	PROPN
admet-1513	1596	27	,	,	PUNCT
admet-1513	1596	28	g.r	g.r	PROPN
admet-1513	1596	29	.	.	PROPN
admet-1513	1596	30	hamersky	hamersky	PROPN
admet-1513	1596	31	,	,	PUNCT
admet-1513	1596	32	f.	f.	PROPN
admet-1513	1596	33	jacob	jacob	PROPN
admet-1513	1596	34	,	,	PUNCT
admet-1513	1596	35	c.	c.	PROPN
admet-1513	1596	36	zhong	zhong	PROPN
admet-1513	1596	37	,	,	PUNCT
admet-1513	1596	38	k.j	k.j	PROPN
admet-1513	1596	39	.	.	PROPN
admet-1513	1596	40	yoon	yoon	PROPN
admet-1513	1596	41	,	,	PUNCT
admet-1513	1596	42	w.	w.	PROPN
admet-1513	1596	43	jeang	jeang	PROPN
admet-1513	1596	44	,	,	PUNCT
admet-1513	1596	45	l.	l.	PROPN
admet-1513	1596	46	lin	lin	PROPN
admet-1513	1596	47	,	,	PUNCT
admet-1513	1596	48	y.	y.	PROPN
admet-1513	1596	49	li	li	PROPN
admet-1513	1596	50	,	,	PUNCT
admet-1513	1596	51	j.	j.	PROPN
admet-1513	1596	52	thakor	thakor	PROPN
admet-1513	1596	53	,	,	PUNCT
admet-1513	1596	54	d.a	d.a	PROPN
admet-1513	1596	55	.	.	PROPN
admet-1513	1596	56	berg	berg	PROPN
admet-1513	1596	57	,	,	PUNCT
admet-1513	1596	58	c.	c.	PROPN
admet-1513	1596	59	zhang	zhang	PROPN
admet-1513	1596	60	,	,	PUNCT
admet-1513	1596	61	e.	e.	PROPN
admet-1513	1596	62	kang	kang	PROPN
admet-1513	1596	63	,	,	PUNCT
admet-1513	1596	64	m.	m.	NOUN
admet-1513	1596	65	chickering	chickering	PROPN
admet-1513	1596	66	,	,	PUNCT
admet-1513	1596	67	d.	d.	PROPN
admet-1513	1596	68	nauen	nauen	PROPN
admet-1513	1596	69	,	,	PUNCT
admet-1513	1596	70	c.y	c.y	PROPN
admet-1513	1596	71	.	.	PROPN
admet-1513	1596	72	ho	ho	PROPN
admet-1513	1596	73	,	,	PUNCT
admet-1513	1596	74	z.	z.	PROPN
admet-1513	1596	75	wen	wen	PROPN
admet-1513	1596	76	,	,	PUNCT
admet-1513	1596	77	k.m	k.m	PROPN
admet-1513	1596	78	.	.	PROPN
admet-1513	1596	79	christian	christian	PROPN
admet-1513	1596	80	,	,	PUNCT
admet-1513	1596	81	p.y	p.y	PROPN
admet-1513	1596	82	.	.	PROPN
admet-1513	1596	83	shi	shi	PROPN
admet-1513	1596	84	,	,	PUNCT
admet-1513	1596	85	b.j	b.j	PROPN
admet-1513	1596	86	.	.	PROPN
admet-1513	1596	87	maher	maher	PROPN
admet-1513	1596	88	,	,	PUNCT
admet-1513	1596	89	h.	h.	PROPN
admet-1513	1596	90	wu	wu	PROPN
admet-1513	1596	91	,	,	PUNCT
admet-1513	1596	92	p.	p.	PROPN
admet-1513	1596	93	jin	jin	PROPN
admet-1513	1596	94	,	,	PUNCT
admet-1513	1596	95	h.	h.	PROPN
admet-1513	1596	96	tang	tang	PROPN
admet-1513	1596	97	,	,	PUNCT
admet-1513	1596	98	h.	h.	PROPN
admet-1513	1596	99	song	song	PROPN
admet-1513	1596	100	,	,	PUNCT
admet-1513	1596	101	g.l	g.l	PROPN
admet-1513	1596	102	.	.	PROPN
admet-1513	1596	103	ming	ming	PROPN
admet-1513	1596	104	.	.	PUNCT
admet-1513	1596	105	brain	brain	NOUN
admet-1513	1596	106	-	-	PUNCT
admet-1513	1596	107	region	region	NOUN
admet-1513	1596	108	-	-	PUNCT
admet-1513	1596	109	specific	specific	ADJ
admet-1513	1596	110	organoids	organoid	NOUN
admet-1513	1596	111	using	use	VERB
admet-1513	1596	112	mini	mini	NOUN
admet-1513	1596	113	-	-	NOUN
admet-1513	1596	114	bioreactors	bioreactor	NOUN
admet-1513	1596	115	for	for	ADP
admet-1513	1596	116	modeling	model	VERB
admet-1513	1596	117	zikv	zikv	NOUN
admet-1513	1596	118	exposure	exposure	NOUN
admet-1513	1596	119	.	.	PUNCT
admet-1513	1597	1	cell	cell	NOUN
admet-1513	1597	2	165	165	NUM
admet-1513	1597	3	(	(	PUNCT
admet-1513	1597	4	2016	2016	NUM
admet-1513	1597	5	)	)	PUNCT
admet-1513	1597	6	1238	1238	NUM
admet-1513	1597	7	-	-	SYM
admet-1513	1597	8	1254	1254	NUM
admet-1513	1597	9	.	.	PUNCT
admet-1513	1598	1	https://doi.org/10.1016/j.cell.2016.04.032	https://doi.org/10.1016/j.cell.2016.04.032	NOUN
admet-1513	1598	2	.	.	PUNCT
admet-1513	1599	1	[	[	X
admet-1513	1599	2	208	208	NUM
admet-1513	1599	3	]	]	X
admet-1513	1599	4	t.	t.	NOUN
admet-1513	1599	5	arzua	arzua	PROPN
admet-1513	1599	6	,	,	PUNCT
admet-1513	1599	7	y.	y.	PROPN
admet-1513	1599	8	yan	yan	PROPN
admet-1513	1599	9	,	,	PUNCT
admet-1513	1599	10	c.	c.	PROPN
admet-1513	1599	11	jiang	jiang	PROPN
admet-1513	1599	12	,	,	PUNCT
admet-1513	1599	13	s.	s.	PROPN
admet-1513	1599	14	logan	logan	PROPN
admet-1513	1599	15	,	,	PUNCT
admet-1513	1599	16	r.l	r.l	PROPN
admet-1513	1599	17	.	.	PROPN
admet-1513	1599	18	allison	allison	PROPN
admet-1513	1599	19	,	,	PUNCT
admet-1513	1599	20	c.	c.	PROPN
admet-1513	1599	21	wells	wells	PROPN
admet-1513	1599	22	,	,	PUNCT
admet-1513	1599	23	s.n	s.n	PROPN
admet-1513	1599	24	.	.	PROPN
admet-1513	1599	25	kumar	kumar	PROPN
admet-1513	1599	26	,	,	PUNCT
admet-1513	1599	27	r.	r.	PROPN
admet-1513	1599	28	schäfer	schäfer	PROPN
admet-1513	1599	29	,	,	PUNCT
admet-1513	1599	30	x.	x.	NOUN
admet-1513	1599	31	bai	bai	PROPN
admet-1513	1599	32	.	.	PUNCT
admet-1513	1600	1	modeling	model	VERB
admet-1513	1600	2	alcohol	alcohol	NOUN
admet-1513	1600	3	-	-	PUNCT
admet-1513	1600	4	induced	induce	VERB
admet-1513	1600	5	neurotoxicity	neurotoxicity	NOUN
admet-1513	1600	6	using	use	VERB
admet-1513	1600	7	human	human	ADJ
admet-1513	1600	8	induced	induced	ADJ
admet-1513	1600	9	pluripotent	pluripotent	NOUN
admet-1513	1600	10	stem	stem	NOUN
admet-1513	1600	11	cell	cell	NOUN
admet-1513	1600	12	-	-	PUNCT
admet-1513	1600	13	derived	derive	VERB
admet-1513	1600	14	three	three	NUM
admet-1513	1600	15	-	-	PUNCT
admet-1513	1600	16	dimensional	dimensional	ADJ
admet-1513	1600	17	cerebral	cerebral	ADJ
admet-1513	1600	18	organoids	organoid	NOUN
admet-1513	1600	19	.	.	PUNCT
admet-1513	1601	1	transl	transl	PROPN
admet-1513	1601	2	.	.	PUNCT
admet-1513	1602	1	psychiatry	psychiatry	NOUN
admet-1513	1602	2	10	10	NUM
admet-1513	1602	3	(	(	PUNCT
admet-1513	1602	4	2020	2020	NUM
admet-1513	1602	5	)	)	PUNCT
admet-1513	1602	6	347	347	NUM
admet-1513	1602	7	.	.	PUNCT
admet-1513	1602	8	https://doi.org/10.1038/s41398-020-01029-4	https://doi.org/10.1038/s41398-020-01029-4	X
admet-1513	1602	9	.	.	PUNCT
admet-1513	1603	1	[	[	X
admet-1513	1603	2	209	209	NUM
admet-1513	1603	3	]	]	PUNCT
admet-1513	1603	4	q.	q.	PROPN
admet-1513	1603	5	bu	bu	PROPN
admet-1513	1603	6	,	,	PUNCT
admet-1513	1603	7	y.	y.	PROPN
admet-1513	1603	8	huang	huang	PROPN
admet-1513	1603	9	,	,	PUNCT
admet-1513	1603	10	m.	m.	PROPN
admet-1513	1603	11	li	li	PROPN
admet-1513	1603	12	,	,	PUNCT
admet-1513	1603	13	y.	y.	PROPN
admet-1513	1603	14	dai	dai	PROPN
admet-1513	1603	15	,	,	PUNCT
admet-1513	1603	16	x.	x.	NOUN
admet-1513	1603	17	fang	fang	PROPN
admet-1513	1603	18	,	,	PUNCT
admet-1513	1603	19	k.	k.	PROPN
admet-1513	1603	20	chen	chen	PROPN
admet-1513	1603	21	,	,	PUNCT
admet-1513	1603	22	q.	q.	PROPN
admet-1513	1603	23	liu	liu	PROPN
admet-1513	1603	24	,	,	PUNCT
admet-1513	1603	25	a.	a.	PROPN
admet-1513	1603	26	xue	xue	PROPN
admet-1513	1603	27	,	,	PUNCT
admet-1513	1603	28	k.	k.	PROPN
admet-1513	1603	29	zhong	zhong	PROPN
admet-1513	1603	30	,	,	PUNCT
admet-1513	1603	31	y.	y.	PROPN
admet-1513	1603	32	huang	huang	PROPN
admet-1513	1603	33	,	,	PUNCT
admet-1513	1603	34	h.	h.	PROPN
admet-1513	1603	35	gao	gao	PROPN
admet-1513	1603	36	,	,	PUNCT
admet-1513	1603	37	x.	x.	PROPN
admet-1513	1603	38	cen	cen	PROPN
admet-1513	1603	39	.	.	PUNCT
admet-1513	1604	1	acrylamide	acrylamide	NOUN
admet-1513	1604	2	exposure	exposure	NOUN
admet-1513	1604	3	represses	repress	VERB
admet-1513	1604	4	neuronal	neuronal	ADJ
admet-1513	1604	5	differentiation	differentiation	NOUN
admet-1513	1604	6	,	,	PUNCT
admet-1513	1604	7	induces	induce	VERB
admet-1513	1604	8	cell	cell	NOUN
admet-1513	1604	9	apoptosis	apoptosis	NOUN
admet-1513	1604	10	and	and	CCONJ
admet-1513	1604	11	promotes	promote	VERB
admet-1513	1604	12	tau	tau	PROPN
admet-1513	1604	13	hyperphosphorylation	hyperphosphorylation	NOUN
admet-1513	1604	14	in	in	ADP
admet-1513	1604	15	hesc	hesc	NOUN
admet-1513	1604	16	-	-	PUNCT
admet-1513	1604	17	derived	derive	VERB
admet-1513	1604	18	3d	3d	NUM
admet-1513	1604	19	cerebral	cerebral	ADJ
admet-1513	1604	20	organoids	organoid	NOUN
admet-1513	1604	21	.	.	PUNCT
admet-1513	1605	1	food	food	NOUN
admet-1513	1605	2	chem	chem	NOUN
admet-1513	1605	3	.	.	PUNCT
admet-1513	1606	1	toxicol	toxicol	PROPN
admet-1513	1606	2	.	.	PUNCT
admet-1513	1607	1	144	144	NUM
admet-1513	1607	2	(	(	PUNCT
admet-1513	1607	3	2020	2020	NUM
admet-1513	1607	4	)	)	PUNCT
admet-1513	1607	5	111643	111643	NUM
admet-1513	1607	6	.	.	PUNCT
admet-1513	1608	1	https://doi.org/10.1016/j.fct.2020.111643	https://doi.org/10.1016/j.fct.2020.111643	PROPN
admet-1513	1608	2	.	.	PUNCT
admet-1513	1609	1	[	[	X
admet-1513	1609	2	210	210	NUM
admet-1513	1609	3	]	]	PUNCT
admet-1513	1609	4	f.	f.	PROPN
admet-1513	1609	5	liu	liu	PROPN
admet-1513	1609	6	,	,	PUNCT
admet-1513	1609	7	j.	j.	PROPN
admet-1513	1609	8	huang	huang	PROPN
admet-1513	1609	9	,	,	PUNCT
admet-1513	1609	10	z.	z.	PROPN
admet-1513	1609	11	liu	liu	PROPN
admet-1513	1609	12	.	.	PROPN
admet-1513	1609	13	vincristine	vincristine	PROPN
admet-1513	1609	14	impairs	impair	VERB
admet-1513	1609	15	microtubules	microtubule	NOUN
admet-1513	1609	16	and	and	CCONJ
admet-1513	1609	17	causes	cause	VERB
admet-1513	1609	18	neurotoxicity	neurotoxicity	NOUN
admet-1513	1609	19	in	in	ADP
admet-1513	1609	20	cerebral	cerebral	ADJ
admet-1513	1609	21	organoids	organoid	NOUN
admet-1513	1609	22	.	.	PUNCT
admet-1513	1610	1	neuroscience	neuroscience	NOUN
admet-1513	1610	2	404	404	NUM
admet-1513	1610	3	(	(	PUNCT
admet-1513	1610	4	2019	2019	NUM
admet-1513	1610	5	)	)	PUNCT
admet-1513	1610	6	530	530	NUM
admet-1513	1610	7	-	-	SYM
admet-1513	1610	8	540	540	NUM
admet-1513	1610	9	.	.	PUNCT
admet-1513	1610	10	https://doi.org/10.1016/j.neuroscience.2018.12.047	https://doi.org/10.1016/j.neuroscience.2018.12.047	NOUN
admet-1513	1610	11	.	.	PUNCT
admet-1513	1611	1	https://doi.org/10.5599/admet.1513	https://doi.org/10.5599/admet.1513	PROPN
admet-1513	1611	2	https://doi.org/10.1177/1535370218801309	https://doi.org/10.1177/1535370218801309	PROPN
admet-1513	1611	3	https://doi.org/10.1177/1535370218801309	https://doi.org/10.1177/1535370218801309	NOUN
admet-1513	1611	4	https://doi.org/10.1016/j.neuro.2014.03.013	https://doi.org/10.1016/j.neuro.2014.03.013	NOUN
admet-1513	1611	5	https://doi.org/10.1038/nrgastro.2016.124	https://doi.org/10.1038/nrgastro.2016.124	PUNCT
admet-1513	1611	6	https://doi.org/10.1016/j.stemcr.2017.11.004	https://doi.org/10.1016/j.stemcr.2017.11.004	VERB
admet-1513	1611	7	https://doi.org/10.1254/fpj.20028	https://doi.org/10.1254/fpj.20028	ADJ
admet-1513	1611	8	https://doi.org/10.1038/nature12517	https://doi.org/10.1038/nature12517	PROPN
admet-1513	1611	9	https://doi.org/10.1016/j.drudis.2019.11.010	https://doi.org/10.1016/j.drudis.2019.11.010	NOUN
admet-1513	1611	10	https://doi.org/10.1038/nmeth.3415	https://doi.org/10.1038/nmeth.3415	NOUN
admet-1513	1611	11	https://doi.org/10.1038/ncomms9896	https://doi.org/10.1038/ncomms9896	PROPN
admet-1513	1611	12	https://doi.org/10.1038/ncomms9896	https://doi.org/10.1038/ncomms9896	PROPN
admet-1513	1611	13	https://doi.org/10.1016/j.celrep.2014.12.051	https://doi.org/10.1016/j.celrep.2014.12.051	PROPN
admet-1513	1611	14	https://doi.org/10.1016/j.cell.2016.04.032	https://doi.org/10.1016/j.cell.2016.04.032	NUM
admet-1513	1611	15	https://doi.org/10.1038/s41398-020-01029-4	https://doi.org/10.1038/s41398-020-01029-4	NUM
admet-1513	1611	16	https://doi.org/10.1016/j.fct.2020.111643	https://doi.org/10.1016/j.fct.2020.111643	PROPN
admet-1513	1611	17	https://doi.org/10.1016/j.neuroscience.2018.12.047	https://doi.org/10.1016/j.neuroscience.2018.12.047	NOUN
admet-1513	1611	18	venkatesh	venkatesh	NOUN
admet-1513	1611	19	chunduri	chunduri	NOUN
admet-1513	1611	20	and	and	CCONJ
admet-1513	1611	21	srinivas	srinivas	PROPN
admet-1513	1611	22	maddi	maddi	PROPN
admet-1513	1611	23	admet	admet	PROPN
admet-1513	1611	24	&	&	CCONJ
admet-1513	1611	25	dmpk	dmpk	PROPN
admet-1513	1611	26	11(1	11(1	NUM
admet-1513	1611	27	)	)	PUNCT
admet-1513	1611	28	(	(	PUNCT
admet-1513	1611	29	2023	2023	NUM
admet-1513	1611	30	)	)	PUNCT
admet-1513	1611	31	1	1	NUM
admet-1513	1611	32	-	-	SYM
admet-1513	1611	33	32	32	NUM
admet-1513	1611	34	32	32	NUM
admet-1513	1612	1	[	[	X
admet-1513	1612	2	211	211	NUM
admet-1513	1612	3	]	]	PUNCT
admet-1513	1612	4	d.	d.	NOUN
admet-1513	1612	5	pamies	pamies	PROPN
admet-1513	1612	6	,	,	PUNCT
admet-1513	1612	7	k.	k.	PROPN
admet-1513	1612	8	block	block	PROPN
admet-1513	1612	9	,	,	PUNCT
admet-1513	1612	10	p.	p.	PROPN
admet-1513	1612	11	lau	lau	PROPN
admet-1513	1612	12	,	,	PUNCT
admet-1513	1612	13	l.	l.	PROPN
admet-1513	1612	14	gribaldo	gribaldo	PROPN
admet-1513	1612	15	,	,	PUNCT
admet-1513	1612	16	c.a	c.a	PROPN
admet-1513	1612	17	.	.	PROPN
admet-1513	1612	18	pardo	pardo	PROPN
admet-1513	1612	19	,	,	PUNCT
admet-1513	1612	20	p.	p.	PROPN
admet-1513	1612	21	barreras	barreras	PROPN
admet-1513	1612	22	,	,	PUNCT
admet-1513	1612	23	l.	l.	PROPN
admet-1513	1612	24	smirnova	smirnova	PROPN
admet-1513	1612	25	,	,	PUNCT
admet-1513	1612	26	d.	d.	PROPN
admet-1513	1612	27	wiersma	wiersma	PROPN
admet-1513	1612	28	,	,	PUNCT
admet-1513	1612	29	l.	l.	PROPN
admet-1513	1612	30	zhao	zhao	PROPN
admet-1513	1612	31	,	,	PUNCT
admet-1513	1612	32	g.	g.	PROPN
admet-1513	1612	33	harris	harris	PROPN
admet-1513	1612	34	,	,	PUNCT
admet-1513	1612	35	t.	t.	PROPN
admet-1513	1612	36	hartung	hartung	PROPN
admet-1513	1612	37	,	,	PUNCT
admet-1513	1612	38	h.t	h.t	PROPN
admet-1513	1612	39	.	.	PROPN
admet-1513	1612	40	hogberg	hogberg	PROPN
admet-1513	1612	41	.	.	PUNCT
admet-1513	1613	1	rotenone	rotenone	NOUN
admet-1513	1613	2	exerts	exert	VERB
admet-1513	1613	3	developmental	developmental	ADJ
admet-1513	1613	4	neurotoxicity	neurotoxicity	NOUN
admet-1513	1613	5	in	in	ADP
admet-1513	1613	6	a	a	DET
admet-1513	1613	7	human	human	ADJ
admet-1513	1613	8	brain	brain	NOUN
admet-1513	1613	9	spheroid	spheroid	PROPN
admet-1513	1613	10	model	model	NOUN
admet-1513	1613	11	.	.	PUNCT
admet-1513	1614	1	toxicol	toxicol	PROPN
admet-1513	1614	2	.	.	PUNCT
admet-1513	1615	1	appl	appl	PROPN
admet-1513	1615	2	.	.	PUNCT
admet-1513	1616	1	pharmacol	pharmacol	PROPN
admet-1513	1616	2	.	.	PUNCT
admet-1513	1617	1	354	354	NUM
admet-1513	1617	2	(	(	PUNCT
admet-1513	1617	3	2018	2018	NUM
admet-1513	1617	4	)	)	PUNCT
admet-1513	1617	5	101	101	NUM
admet-1513	1617	6	-	-	SYM
admet-1513	1617	7	114	114	NUM
admet-1513	1617	8	.	.	PUNCT
admet-1513	1618	1	https://doi.org/10.1016/j.taap.2018.02.003	https://doi.org/10.1016/j.taap.2018.02.003	ADJ
admet-1513	1618	2	.	.	PUNCT
admet-1513	1619	1	[	[	X
admet-1513	1619	2	212	212	NUM
admet-1513	1619	3	]	]	X
admet-1513	1619	4	c.c	c.c	PROPN
admet-1513	1619	5	.	.	PROPN
admet-1513	1619	6	miranda	miranda	PROPN
admet-1513	1619	7	,	,	PUNCT
admet-1513	1619	8	t.g	t.g	PROPN
admet-1513	1619	9	.	.	PROPN
admet-1513	1619	10	fernandes	fernandes	PROPN
admet-1513	1619	11	,	,	PUNCT
admet-1513	1619	12	m.m	m.m	PROPN
admet-1513	1619	13	.	.	PROPN
admet-1513	1619	14	diogo	diogo	PROPN
admet-1513	1619	15	,	,	PUNCT
admet-1513	1619	16	j.m.s	j.m.s	PROPN
admet-1513	1619	17	.	.	PUNCT
admet-1513	1619	18	cabral	cabral	PROPN
admet-1513	1619	19	.	.	PROPN
admet-1513	1620	1	towards	towards	ADP
admet-1513	1620	2	multi	multi	ADJ
admet-1513	1620	3	-	-	ADJ
admet-1513	1620	4	organoid	organoid	ADJ
admet-1513	1620	5	systems	system	NOUN
admet-1513	1620	6	for	for	ADP
admet-1513	1620	7	drug	drug	NOUN
admet-1513	1620	8	screening	screening	NOUN
admet-1513	1620	9	applications	application	NOUN
admet-1513	1620	10	.	.	PUNCT
admet-1513	1621	1	bioengineering	bioengineering	NOUN
admet-1513	1621	2	(	(	PUNCT
admet-1513	1621	3	basel	basel	PROPN
admet-1513	1621	4	)	)	PUNCT
admet-1513	1621	5	5	5	NUM
admet-1513	1621	6	(	(	PUNCT
admet-1513	1621	7	2018	2018	NUM
admet-1513	1621	8	)	)	PUNCT
admet-1513	1621	9	e49	e49	PROPN
admet-1513	1621	10	.	.	PUNCT
admet-1513	1622	1	https://doi.org/10.3390/bioengineering5030049	https://doi.org/10.3390/bioengineering5030049	PROPN
admet-1513	1622	2	.	.	PUNCT
admet-1513	1623	1	[	[	X
admet-1513	1623	2	213	213	NUM
admet-1513	1623	3	]	]	X
admet-1513	1623	4	w.l.k	w.l.k	NOUN
admet-1513	1623	5	.	.	PUNCT
admet-1513	1624	1	chen	chen	PROPN
admet-1513	1624	2	,	,	PUNCT
admet-1513	1624	3	c.	c.	PROPN
admet-1513	1624	4	edington	edington	PROPN
admet-1513	1624	5	,	,	PUNCT
admet-1513	1624	6	e.	e.	PROPN
admet-1513	1624	7	suter	suter	PROPN
admet-1513	1624	8	,	,	PUNCT
admet-1513	1624	9	j.	j.	PROPN
admet-1513	1624	10	yu	yu	PROPN
admet-1513	1624	11	,	,	PUNCT
admet-1513	1624	12	j.j	j.j	PROPN
admet-1513	1624	13	.	.	PROPN
admet-1513	1624	14	velazquez	velazquez	PROPN
admet-1513	1624	15	,	,	PUNCT
admet-1513	1624	16	j.g	j.g	PROPN
admet-1513	1624	17	.	.	PROPN
admet-1513	1624	18	velazquez	velazquez	PROPN
admet-1513	1624	19	,	,	PUNCT
admet-1513	1624	20	m.	m.	PROPN
admet-1513	1624	21	shockley	shockley	PROPN
admet-1513	1624	22	,	,	PUNCT
admet-1513	1624	23	e.m	e.m	PROPN
admet-1513	1624	24	.	.	PROPN
admet-1513	1624	25	large	large	PROPN
admet-1513	1624	26	,	,	PUNCT
admet-1513	1624	27	r.	r.	PROPN
admet-1513	1624	28	venkataramanan	venkataramanan	PROPN
admet-1513	1624	29	,	,	PUNCT
admet-1513	1624	30	d.j	d.j	PROPN
admet-1513	1624	31	.	.	PROPN
admet-1513	1624	32	hughes	hughes	PROPN
admet-1513	1624	33	,	,	PUNCT
admet-1513	1624	34	c.l	c.l	PROPN
admet-1513	1624	35	.	.	PROPN
admet-1513	1624	36	stokes	stokes	PROPN
admet-1513	1624	37	,	,	PUNCT
admet-1513	1624	38	d.l	d.l	PROPN
admet-1513	1624	39	.	.	PROPN
admet-1513	1624	40	trumper	trumper	PROPN
admet-1513	1624	41	,	,	PUNCT
admet-1513	1624	42	r.l	r.l	PROPN
admet-1513	1624	43	.	.	PROPN
admet-1513	1624	44	carrier	carrier	PROPN
admet-1513	1624	45	,	,	PUNCT
admet-1513	1624	46	m.	m.	NOUN
admet-1513	1624	47	cirit	cirit	PROPN
admet-1513	1624	48	,	,	PUNCT
admet-1513	1624	49	l.g	l.g	PROPN
admet-1513	1624	50	.	.	PROPN
admet-1513	1624	51	griffith	griffith	PROPN
admet-1513	1624	52	,	,	PUNCT
admet-1513	1624	53	d.a	d.a	PROPN
admet-1513	1624	54	.	.	PROPN
admet-1513	1624	55	lauffenburger	lauffenburger	NOUN
admet-1513	1624	56	.	.	PUNCT
admet-1513	1625	1	integrated	integrated	ADJ
admet-1513	1625	2	gut	gut	NOUN
admet-1513	1625	3	/	/	SYM
admet-1513	1625	4	liver	liver	NOUN
admet-1513	1625	5	microphysiological	microphysiological	ADJ
admet-1513	1625	6	systems	system	NOUN
admet-1513	1625	7	elucidates	elucidate	VERB
admet-1513	1625	8	inflammatory	inflammatory	ADJ
admet-1513	1625	9	inter	inter	ADJ
admet-1513	1625	10	-	-	ADJ
admet-1513	1625	11	tissue	tissue	ADJ
admet-1513	1625	12	crosstalk	crosstalk	NOUN
admet-1513	1625	13	.	.	PUNCT
admet-1513	1626	1	biotechnol	biotechnol	NOUN
admet-1513	1626	2	.	.	PUNCT
admet-1513	1627	1	bioeng	bioeng	PROPN
admet-1513	1627	2	.	.	PROPN
admet-1513	1628	1	114	114	NUM
admet-1513	1628	2	(	(	PUNCT
admet-1513	1628	3	2017	2017	NUM
admet-1513	1628	4	)	)	PUNCT
admet-1513	1628	5	2648	2648	NUM
admet-1513	1628	6	-	-	SYM
admet-1513	1628	7	2659	2659	NUM
admet-1513	1628	8	.	.	PUNCT
admet-1513	1629	1	https://doi.org/10.1002/bit.26370	https://doi.org/10.1002/bit.26370	NOUN
admet-1513	1629	2	.	.	PUNCT
admet-1513	1630	1	[	[	X
admet-1513	1630	2	214	214	NUM
admet-1513	1630	3	]	]	X
admet-1513	1630	4	c.d	c.d	PROPN
admet-1513	1630	5	.	.	PROPN
admet-1513	1630	6	edington	edington	PROPN
admet-1513	1630	7	,	,	PUNCT
admet-1513	1630	8	w.l.k	w.l.k	PROPN
admet-1513	1630	9	.	.	PUNCT
admet-1513	1631	1	chen	chen	PROPN
admet-1513	1631	2	,	,	PUNCT
admet-1513	1631	3	e.	e.	PROPN
admet-1513	1631	4	geishecker	geishecker	PROPN
admet-1513	1631	5	,	,	PUNCT
admet-1513	1631	6	t.	t.	NOUN
admet-1513	1631	7	kassis	kassis	NOUN
admet-1513	1631	8	,	,	PUNCT
admet-1513	1631	9	l.r	l.r	PROPN
admet-1513	1631	10	.	.	PROPN
admet-1513	1631	11	soenksen	soenksen	PROPN
admet-1513	1631	12	,	,	PUNCT
admet-1513	1631	13	b.m	b.m	PROPN
admet-1513	1631	14	.	.	PROPN
admet-1513	1631	15	bhushan	bhushan	PROPN
admet-1513	1631	16	,	,	PUNCT
admet-1513	1631	17	d.	d.	PROPN
admet-1513	1631	18	freake	freake	PROPN
admet-1513	1631	19	,	,	PUNCT
admet-1513	1631	20	j.	j.	PROPN
admet-1513	1631	21	kirschner	kirschner	PROPN
admet-1513	1631	22	,	,	PUNCT
admet-1513	1631	23	c.	c.	PROPN
admet-1513	1631	24	maass	maass	PROPN
admet-1513	1631	25	,	,	PUNCT
admet-1513	1631	26	n.	n.	PROPN
admet-1513	1631	27	tsamandouras	tsamandouras	PROPN
admet-1513	1631	28	,	,	PUNCT
admet-1513	1631	29	j.	j.	PROPN
admet-1513	1631	30	valdez	valdez	PROPN
admet-1513	1631	31	,	,	PUNCT
admet-1513	1631	32	c.d	c.d	PROPN
admet-1513	1631	33	.	.	PROPN
admet-1513	1631	34	cook	cook	PROPN
admet-1513	1631	35	,	,	PUNCT
admet-1513	1631	36	t.	t.	NOUN
admet-1513	1631	37	parent	parent	NOUN
admet-1513	1631	38	,	,	PUNCT
admet-1513	1631	39	s.	s.	PROPN
admet-1513	1631	40	snyder	snyder	PROPN
admet-1513	1631	41	,	,	PUNCT
admet-1513	1631	42	j.	j.	PROPN
admet-1513	1631	43	yu	yu	PROPN
admet-1513	1631	44	,	,	PUNCT
admet-1513	1631	45	e.	e.	PROPN
admet-1513	1631	46	suter	suter	PROPN
admet-1513	1631	47	,	,	PUNCT
admet-1513	1631	48	m.	m.	NOUN
admet-1513	1631	49	shockley	shockley	PROPN
admet-1513	1631	50	,	,	PUNCT
admet-1513	1631	51	j.	j.	PROPN
admet-1513	1631	52	velazquez	velazquez	PROPN
admet-1513	1631	53	,	,	PUNCT
admet-1513	1631	54	j.j	j.j	PROPN
admet-1513	1631	55	.	.	PROPN
admet-1513	1631	56	velazquez	velazquez	PROPN
admet-1513	1631	57	,	,	PUNCT
admet-1513	1631	58	l.	l.	PROPN
admet-1513	1631	59	stockdale	stockdale	PROPN
admet-1513	1631	60	,	,	PUNCT
admet-1513	1631	61	j.p	j.p	PROPN
admet-1513	1631	62	.	.	PROPN
admet-1513	1631	63	papps	papps	PROPN
admet-1513	1631	64	,	,	PUNCT
admet-1513	1631	65	i.	i.	PROPN
admet-1513	1631	66	lee	lee	PROPN
admet-1513	1631	67	,	,	PUNCT
admet-1513	1631	68	n.	n.	PROPN
admet-1513	1631	69	vann	vann	PROPN
admet-1513	1631	70	,	,	PUNCT
admet-1513	1631	71	m.	m.	NOUN
admet-1513	1631	72	gamboa	gamboa	PROPN
admet-1513	1631	73	,	,	PUNCT
admet-1513	1631	74	m.e	m.e	PROPN
admet-1513	1631	75	.	.	PROPN
admet-1513	1631	76	labarge	labarge	NOUN
admet-1513	1631	77	,	,	PUNCT
admet-1513	1631	78	z.	z.	PROPN
admet-1513	1631	79	zhong	zhong	PROPN
admet-1513	1631	80	,	,	PUNCT
admet-1513	1631	81	x.	x.	PROPN
admet-1513	1631	82	wang	wang	PROPN
admet-1513	1631	83	,	,	PUNCT
admet-1513	1631	84	l.a	l.a	PROPN
admet-1513	1631	85	.	.	PROPN
admet-1513	1631	86	boyer	boyer	PROPN
admet-1513	1631	87	,	,	PUNCT
admet-1513	1631	88	d.a	d.a	PROPN
admet-1513	1631	89	.	.	PROPN
admet-1513	1631	90	lauffenburger	lauffenburger	PROPN
admet-1513	1631	91	,	,	PUNCT
admet-1513	1631	92	r.l	r.l	PROPN
admet-1513	1631	93	.	.	PROPN
admet-1513	1631	94	carrier	carrier	PROPN
admet-1513	1631	95	,	,	PUNCT
admet-1513	1631	96	c.	c.	PROPN
admet-1513	1631	97	communal	communal	PROPN
admet-1513	1631	98	,	,	PUNCT
admet-1513	1631	99	s.r	s.r	PROPN
admet-1513	1631	100	.	.	PROPN
admet-1513	1631	101	tannenbaum	tannenbaum	PROPN
admet-1513	1631	102	,	,	PUNCT
admet-1513	1631	103	c.l	c.l	PROPN
admet-1513	1631	104	.	.	PROPN
admet-1513	1631	105	stokes	stokes	PROPN
admet-1513	1631	106	,	,	PUNCT
admet-1513	1631	107	d.j	d.j	PROPN
admet-1513	1631	108	.	.	PROPN
admet-1513	1631	109	hughes	hughes	PROPN
admet-1513	1631	110	,	,	PUNCT
admet-1513	1631	111	g.	g.	PROPN
admet-1513	1631	112	rohatgi	rohatgi	PROPN
admet-1513	1631	113	,	,	PUNCT
admet-1513	1631	114	d.l	d.l	PROPN
admet-1513	1631	115	.	.	PROPN
admet-1513	1631	116	trumper	trumper	PROPN
admet-1513	1631	117	,	,	PUNCT
admet-1513	1631	118	m.	m.	NOUN
admet-1513	1631	119	cirit	cirit	PROPN
admet-1513	1631	120	,	,	PUNCT
admet-1513	1631	121	l.g	l.g	PROPN
admet-1513	1631	122	.	.	PROPN
admet-1513	1631	123	griffith	griffith	PROPN
admet-1513	1631	124	.	.	PUNCT
admet-1513	1632	1	interconnected	interconnect	VERB
admet-1513	1632	2	microphysiological	microphysiological	ADJ
admet-1513	1632	3	systems	system	NOUN
admet-1513	1632	4	for	for	ADP
admet-1513	1632	5	quantitative	quantitative	ADJ
admet-1513	1632	6	biology	biology	NOUN
admet-1513	1632	7	and	and	CCONJ
admet-1513	1632	8	pharmacology	pharmacology	NOUN
admet-1513	1632	9	studies	study	NOUN
admet-1513	1632	10	.	.	PUNCT
admet-1513	1633	1	sci	sci	PROPN
admet-1513	1633	2	.	.	PROPN
admet-1513	1633	3	rep	rep	PROPN
admet-1513	1633	4	.	.	PROPN
admet-1513	1633	5	8	8	NUM
admet-1513	1633	6	(	(	PUNCT
admet-1513	1633	7	2018	2018	NUM
admet-1513	1633	8	)	)	PUNCT
admet-1513	1633	9	4530	4530	NUM
admet-1513	1633	10	.	.	PUNCT
admet-1513	1634	1	https://doi.org/10.1038/s41598-018-22749-0	https://doi.org/10.1038/s41598-018-22749-0	NUM
admet-1513	1634	2	.	.	PUNCT
admet-1513	1635	1	©	©	NOUN
admet-1513	1635	2	2022	2022	NUM
admet-1513	1635	3	by	by	ADP
admet-1513	1635	4	the	the	DET
admet-1513	1635	5	authors	author	NOUN
admet-1513	1635	6	;	;	PUNCT
admet-1513	1635	7	licensee	licensee	PROPN
admet-1513	1635	8	iapc	iapc	PROPN
admet-1513	1635	9	,	,	PUNCT
admet-1513	1635	10	zagreb	zagreb	PROPN
admet-1513	1635	11	,	,	PUNCT
admet-1513	1635	12	croatia	croatia	PROPN
admet-1513	1635	13	.	.	PUNCT
admet-1513	1636	1	this	this	DET
admet-1513	1636	2	article	article	NOUN
admet-1513	1636	3	is	be	AUX
admet-1513	1636	4	an	an	DET
admet-1513	1636	5	open	open	ADJ
admet-1513	1636	6	-	-	PUNCT
admet-1513	1636	7	access	access	NOUN
admet-1513	1636	8	article	article	NOUN
admet-1513	1636	9	distributed	distribute	VERB
admet-1513	1636	10	under	under	ADP
admet-1513	1636	11	the	the	DET
admet-1513	1636	12	terms	term	NOUN
admet-1513	1636	13	and	and	CCONJ
admet-1513	1636	14	conditions	condition	NOUN
admet-1513	1636	15	of	of	ADP
admet-1513	1636	16	the	the	DET
admet-1513	1636	17	creative	creative	ADJ
admet-1513	1636	18	commons	common	NOUN
admet-1513	1636	19	attribution	attribution	NOUN
admet-1513	1636	20	license	license	NOUN
admet-1513	1636	21	(	(	PUNCT
admet-1513	1636	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1513	1636	23	)	)	PUNCT
admet-1513	1636	24	https://doi.org/10.1016/j.taap.2018.02.003	https://doi.org/10.1016/j.taap.2018.02.003	ADJ
admet-1513	1636	25	https://doi.org/10.1016/j.taap.2018.02.003	https://doi.org/10.1016/j.taap.2018.02.003	ADJ
admet-1513	1636	26	https://doi.org/10.3390/bioengineering5030049	https://doi.org/10.3390/bioengineering5030049	NOUN
admet-1513	1636	27	https://doi.org/10.3390/bioengineering5030049	https://doi.org/10.3390/bioengineering5030049	PROPN
admet-1513	1636	28	https://doi.org/10.1002/bit.26370	https://doi.org/10.1002/bit.26370	PROPN
admet-1513	1636	29	https://doi.org/10.1038/s41598-018-22749-0	https://doi.org/10.1038/s41598-018-22749-0	NUM
admet-1513	1636	30	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1513	1636	31	)	)	PUNCT