id	sid	tid	token	lemma	pos
admet-155	1	1	manuscript	manuscript	PROPN
admet-155	1	2	doi	doi	PROPN
admet-155	1	3	:	:	PUNCT
admet-155	1	4	10.5599	10.5599	NUM
admet-155	1	5	/	/	SYM
admet-155	1	6	admet.2.4.155	admet.2.4.155	PROPN
admet-155	1	7	248	248	NUM
admet-155	1	8	admet	admet	X
admet-155	1	9	&	&	CCONJ
admet-155	1	10	dmpk	dmpk	PROPN
admet-155	1	11	2(4	2(4	NUM
admet-155	1	12	)	)	PUNCT
admet-155	1	13	(	(	PUNCT
admet-155	1	14	2014	2014	NUM
admet-155	1	15	)	)	PUNCT
admet-155	1	16	248	248	NUM
admet-155	1	17	-	-	SYM
admet-155	1	18	253	253	NUM
admet-155	1	19	;	;	PUNCT
admet-155	1	20	doi	doi	NOUN
admet-155	1	21	:	:	PUNCT
admet-155	1	22	10.5599	10.5599	NUM
admet-155	1	23	/	/	SYM
admet-155	1	24	admet.2.4.155	admet.2.4.155	ADV
admet-155	1	25	open	open	ADJ
admet-155	1	26	access	access	NOUN
admet-155	1	27	:	:	PUNCT
admet-155	1	28	issn	issn	PROPN
admet-155	1	29	:	:	PUNCT
admet-155	1	30	1848	1848	NUM
admet-155	1	31	-	-	SYM
admet-155	1	32	7718	7718	NUM
admet-155	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-155	1	34	original	original	ADJ
admet-155	1	35	scientific	scientific	ADJ
admet-155	1	36	paper	paper	NOUN
admet-155	1	37	rapid	rapid	ADJ
admet-155	1	38	screening	screening	NOUN
admet-155	1	39	of	of	ADP
admet-155	1	40	permeation	permeation	NOUN
admet-155	1	41	of	of	ADP
admet-155	1	42	rutin	rutin	NOUN
admet-155	1	43	through	through	ADP
admet-155	1	44	skin	skin	NOUN
admet-155	1	45	using	use	VERB
admet-155	1	46	alaptide	alaptide	ADJ
admet-155	1	47	enantiomers	enantiomer	NOUN
admet-155	1	48	aneta	aneta	PROPN
admet-155	1	49	cernikova	cernikova	PROPN
admet-155	1	50	,	,	PUNCT
admet-155	1	51	radka	radka	NOUN
admet-155	1	52	opatrilova	opatrilova	PROPN
admet-155	1	53	,	,	PUNCT
admet-155	1	54	pavel	pavel	PROPN
admet-155	1	55	bobal	bobal	PROPN
admet-155	1	56	and	and	CCONJ
admet-155	1	57	josef	josef	PROPN
admet-155	1	58	jampilek	jampilek	PROPN
admet-155	1	59	department	department	PROPN
admet-155	1	60	of	of	ADP
admet-155	1	61	chemical	chemical	NOUN
admet-155	1	62	drugs	drug	NOUN
admet-155	1	63	,	,	PUNCT
admet-155	1	64	faculty	faculty	NOUN
admet-155	1	65	of	of	ADP
admet-155	1	66	pharmacy	pharmacy	NOUN
admet-155	1	67	,	,	PUNCT
admet-155	1	68	university	university	NOUN
admet-155	1	69	of	of	ADP
admet-155	1	70	veterinary	veterinary	ADJ
admet-155	1	71	and	and	CCONJ
admet-155	1	72	pharmaceutical	pharmaceutical	NOUN
admet-155	1	73	sciences	science	NOUN
admet-155	1	74	,	,	PUNCT
admet-155	1	75	palackeho	palackeho	VERB
admet-155	1	76	1/3	1/3	NUM
admet-155	1	77	,	,	PUNCT
admet-155	1	78	61242	61242	NUM
admet-155	1	79	brno	brno	NOUN
admet-155	1	80	,	,	PUNCT
admet-155	1	81	czech	czech	PROPN
admet-155	1	82	republic	republic	NOUN
admet-155	1	83	corresponding	corresponde	VERB
admet-155	2	1	author	author	NOUN
admet-155	2	2	:	:	PUNCT
admet-155	2	3	e	e	NOUN
admet-155	2	4	-	-	NOUN
admet-155	2	5	mail	mail	NOUN
admet-155	2	6	:	:	PUNCT
admet-155	2	7	josef.jampilek@gmail.com	josef.jampilek@gmail.com	X
admet-155	2	8	;	;	PUNCT
admet-155	2	9	tel	tel	PROPN
admet-155	2	10	.	.	PROPN
admet-155	2	11	:	:	PUNCT
admet-155	3	1	+420	+420	NUM
admet-155	3	2	-	-	SYM
admet-155	3	3	541	541	NUM
admet-155	3	4	-	-	PUNCT
admet-155	3	5	562	562	NUM
admet-155	3	6	-	-	PUNCT
admet-155	3	7	926	926	NUM
admet-155	3	8	received	receive	VERB
admet-155	3	9	:	:	PUNCT
admet-155	3	10	december	december	PROPN
admet-155	3	11	21	21	NUM
admet-155	3	12	,	,	PUNCT
admet-155	3	13	2014	2014	NUM
admet-155	3	14	;	;	PUNCT
admet-155	3	15	revised	revise	VERB
admet-155	3	16	:	:	PUNCT
admet-155	3	17	december	december	PROPN
admet-155	3	18	22	22	NUM
admet-155	3	19	,	,	PUNCT
admet-155	3	20	2014	2014	NUM
admet-155	3	21	;	;	PUNCT
admet-155	3	22	published	publish	VERB
admet-155	3	23	:	:	PUNCT
admet-155	3	24	january	january	PROPN
admet-155	3	25	09	09	NUM
admet-155	3	26	,	,	PUNCT
admet-155	3	27	2015	2015	NUM
admet-155	3	28	abstract	abstract	NOUN
admet-155	3	29	the	the	DET
admet-155	3	30	investigation	investigation	NOUN
admet-155	3	31	deals	deal	VERB
admet-155	3	32	with	with	ADP
admet-155	3	33	the	the	DET
admet-155	3	34	influence	influence	NOUN
admet-155	3	35	of	of	ADP
admet-155	3	36	permeation	permeation	NOUN
admet-155	3	37	of	of	ADP
admet-155	3	38	rutin	rutin	NOUN
admet-155	3	39	from	from	ADP
admet-155	3	40	carboxymethyl	carboxymethyl	NOUN
admet-155	3	41	cellulose	cellulose	NOUN
admet-155	3	42	gel	gel	NOUN
admet-155	3	43	through	through	ADP
admet-155	3	44	full	full	ADJ
admet-155	3	45	-	-	PUNCT
admet-155	3	46	thickness	thickness	NOUN
admet-155	3	47	pig	pig	NOUN
admet-155	3	48	ear	ear	VERB
admet-155	3	49	skin	skin	NOUN
admet-155	3	50	by	by	ADP
admet-155	3	51	(	(	PUNCT
admet-155	3	52	s)and	s)and	NOUN
admet-155	3	53	(	(	PUNCT
admet-155	3	54	r)-alaptide	r)-alaptide	PUNCT
admet-155	3	55	as	as	ADP
admet-155	3	56	potential	potential	ADJ
admet-155	3	57	excipients	excipient	NOUN
admet-155	3	58	.	.	PUNCT
admet-155	4	1	alaptide	alaptide	ADJ
admet-155	4	2	,	,	PUNCT
admet-155	4	3	8	8	NUM
admet-155	4	4	-	-	PUNCT
admet-155	4	5	methyl-6,9diazaspiro[4.5]decan-7,10	methyl-6,9diazaspiro[4.5]decan-7,10	NOUN
admet-155	4	6	-	-	PUNCT
admet-155	4	7	dione	dione	NOUN
admet-155	4	8	,	,	PUNCT
admet-155	4	9	is	be	AUX
admet-155	4	10	the	the	DET
admet-155	4	11	original	original	ADJ
admet-155	4	12	czech	czech	ADJ
admet-155	4	13	compound	compound	NOUN
admet-155	4	14	.	.	PUNCT
admet-155	5	1	by	by	ADP
admet-155	5	2	means	mean	NOUN
admet-155	5	3	of	of	ADP
admet-155	5	4	this	this	DET
admet-155	5	5	rapid	rapid	ADJ
admet-155	5	6	screening	screening	NOUN
admet-155	5	7	it	it	PRON
admet-155	5	8	was	be	AUX
admet-155	5	9	found	find	VERB
admet-155	5	10	out	out	ADP
admet-155	5	11	that	that	SCONJ
admet-155	5	12	the	the	DET
admet-155	5	13	permeation	permeation	NOUN
admet-155	5	14	of	of	ADP
admet-155	5	15	rutin	rutin	NOUN
admet-155	5	16	through	through	ADP
admet-155	5	17	the	the	DET
admet-155	5	18	skin	skin	NOUN
admet-155	5	19	increased	increase	VERB
admet-155	5	20	linearly	linearly	ADV
admet-155	5	21	with	with	ADP
admet-155	5	22	time	time	NOUN
admet-155	5	23	and	and	CCONJ
admet-155	5	24	was	be	AUX
admet-155	5	25	enhanced	enhance	VERB
admet-155	5	26	by	by	ADP
admet-155	5	27	both	both	DET
admet-155	5	28	enantiomers	enantiomer	NOUN
admet-155	5	29	of	of	ADP
admet-155	5	30	alaptide	alaptide	NOUN
admet-155	5	31	:	:	PUNCT
admet-155	5	32	approx	approx	PROPN
admet-155	5	33	.	.	PUNCT
admet-155	6	1	1.2	1.2	NUM
admet-155	6	2	-	-	NOUN
admet-155	6	3	fold	fold	VERB
admet-155	6	4	by	by	ADV
admet-155	6	5	(	(	PUNCT
admet-155	6	6	r)-alaptide	r)-alaptide	NOUN
admet-155	6	7	and	and	CCONJ
admet-155	6	8	approx	approx	NOUN
admet-155	6	9	.	.	PUNCT
admet-155	7	1	1.5	1.5	NUM
admet-155	7	2	-	-	NOUN
admet-155	7	3	fold	fold	ADJ
admet-155	7	4	by	by	ADV
admet-155	7	5	(	(	PUNCT
admet-155	7	6	s)-alaptide	s)-alaptide	NOUN
admet-155	7	7	.	.	PUNCT
admet-155	8	1	keywords	keyword	NOUN
admet-155	8	2	(	(	PUNCT
admet-155	8	3	s)-alaptide	s)-alaptide	ADJ
admet-155	8	4	;	;	PUNCT
admet-155	8	5	(	(	PUNCT
admet-155	8	6	r)-alaptide	r)-alaptide	NOUN
admet-155	8	7	,	,	PUNCT
admet-155	8	8	rutin	rutin	NOUN
admet-155	8	9	;	;	PUNCT
admet-155	8	10	carboxymethyl	carboxymethyl	NOUN
admet-155	8	11	cellulose	cellulose	NOUN
admet-155	8	12	gel	gel	NOUN
admet-155	8	13	;	;	PUNCT
admet-155	8	14	skin	skin	NOUN
admet-155	8	15	permeation	permeation	NOUN
admet-155	8	16	modifiers	modifier	NOUN
admet-155	8	17	.	.	PUNCT
admet-155	9	1	introduction	introduction	NOUN
admet-155	9	2	permeation	permeation	NOUN
admet-155	9	3	modifiers	modifier	NOUN
admet-155	9	4	(	(	PUNCT
admet-155	9	5	enhancers	enhancer	NOUN
admet-155	9	6	and	and	CCONJ
admet-155	9	7	retardants	retardant	NOUN
admet-155	9	8	)	)	PUNCT
admet-155	9	9	affect	affect	VERB
admet-155	9	10	the	the	DET
admet-155	9	11	barrier	barrier	NOUN
admet-155	9	12	properties	property	NOUN
admet-155	9	13	of	of	ADP
admet-155	9	14	the	the	DET
admet-155	9	15	skin	skin	NOUN
admet-155	9	16	.	.	PUNCT
admet-155	10	1	chemical	chemical	ADJ
admet-155	10	2	permeation	permeation	NOUN
admet-155	10	3	enhancers	enhancer	NOUN
admet-155	10	4	(	(	PUNCT
admet-155	10	5	cpes	cpe	NOUN
admet-155	10	6	)	)	PUNCT
admet-155	10	7	are	be	AUX
admet-155	10	8	employed	employ	VERB
admet-155	10	9	to	to	PART
admet-155	10	10	increase	increase	VERB
admet-155	10	11	the	the	DET
admet-155	10	12	transdermal	transdermal	ADJ
admet-155	10	13	penetration	penetration	NOUN
admet-155	10	14	of	of	ADP
admet-155	10	15	therapeutic	therapeutic	ADJ
admet-155	10	16	agents	agent	NOUN
admet-155	11	1	[	[	X
admet-155	11	2	1−6	1−6	NUM
admet-155	11	3	and	and	CCONJ
admet-155	11	4	refs	ref	NOUN
admet-155	11	5	.	.	PUNCT
admet-155	12	1	therein	therein	ADV
admet-155	12	2	]	]	PUNCT
admet-155	12	3	.	.	PUNCT
admet-155	13	1	alaptide	alaptide	PROPN
admet-155	13	2	,	,	PUNCT
admet-155	13	3	(	(	PUNCT
admet-155	13	4	s)-8	s)-8	NOUN
admet-155	13	5	-	-	PUNCT
admet-155	13	6	methyl-6,9	methyl-6,9	NUM
admet-155	13	7	-	-	PUNCT
admet-155	13	8	diazaspiro[4.5]decan-7,10	diazaspiro[4.5]decan-7,10	NOUN
admet-155	13	9	-	-	PUNCT
admet-155	13	10	dione	dione	NOUN
admet-155	13	11	(	(	PUNCT
admet-155	13	12	see	see	VERB
admet-155	13	13	fig	fig	NOUN
admet-155	13	14	.	.	PUNCT
admet-155	14	1	1	1	NUM
admet-155	14	2	)	)	PUNCT
admet-155	14	3	was	be	AUX
admet-155	14	4	designed	design	VERB
admet-155	14	5	as	as	ADP
admet-155	14	6	an	an	DET
admet-155	14	7	analogue	analogue	NOUN
admet-155	14	8	of	of	ADP
admet-155	14	9	melanocyte	melanocyte	NOUN
admet-155	14	10	-	-	PUNCT
admet-155	14	11	stimulating	stimulate	VERB
admet-155	14	12	hormone	hormone	NOUN
admet-155	14	13	release	release	NOUN
admet-155	14	14	-	-	PUNCT
admet-155	14	15	inhibiting	inhibit	VERB
admet-155	14	16	factor	factor	NOUN
admet-155	14	17	(	(	PUNCT
admet-155	14	18	mif-1	mif-1	NUM
admet-155	14	19	)	)	PUNCT
admet-155	15	1	[	[	X
admet-155	15	2	7−10	7−10	NUM
admet-155	15	3	]	]	PUNCT
admet-155	15	4	and	and	CCONJ
admet-155	15	5	thus	thus	ADV
admet-155	15	6	is	be	AUX
admet-155	15	7	able	able	ADJ
admet-155	15	8	to	to	PART
admet-155	15	9	influence	influence	VERB
admet-155	15	10	the	the	DET
admet-155	15	11	creation	creation	NOUN
admet-155	15	12	and	and	CCONJ
admet-155	15	13	function	function	NOUN
admet-155	15	14	of	of	ADP
admet-155	15	15	keratinocytes	keratinocyte	NOUN
admet-155	16	1	[	[	X
admet-155	16	2	11−13	11−13	X
admet-155	16	3	]	]	PUNCT
admet-155	16	4	.	.	PUNCT
admet-155	17	1	based	base	VERB
admet-155	17	2	on	on	ADP
admet-155	17	3	these	these	DET
admet-155	17	4	facts	fact	NOUN
admet-155	17	5	and	and	CCONJ
admet-155	17	6	structural	structural	ADJ
admet-155	17	7	analogy	analogy	NOUN
admet-155	17	8	with	with	ADP
admet-155	17	9	other	other	ADJ
admet-155	17	10	cpes	cpe	NOUN
admet-155	17	11	[	[	X
admet-155	17	12	4	4	NUM
admet-155	17	13	]	]	PUNCT
admet-155	17	14	,	,	PUNCT
admet-155	17	15	it	it	PRON
admet-155	17	16	was	be	AUX
admet-155	17	17	suggested	suggest	VERB
admet-155	17	18	to	to	PART
admet-155	17	19	investigate	investigate	VERB
admet-155	17	20	alaptide	alaptide	ADV
admet-155	17	21	as	as	ADP
admet-155	17	22	a	a	DET
admet-155	17	23	potential	potential	ADJ
admet-155	17	24	cpe	cpe	NOUN
admet-155	17	25	of	of	ADP
admet-155	17	26	many	many	ADJ
admet-155	17	27	anti	anti	ADJ
admet-155	17	28	-	-	ADJ
admet-155	17	29	inflammatory	inflammatory	ADJ
admet-155	17	30	drugs	drug	NOUN
admet-155	17	31	,	,	PUNCT
admet-155	17	32	antimicrobial	antimicrobial	ADJ
admet-155	17	33	chemotherapeutics	chemotherapeutic	NOUN
admet-155	17	34	,	,	PUNCT
admet-155	17	35	sex	sex	NOUN
admet-155	17	36	hormones	hormone	NOUN
admet-155	17	37	/	/	SYM
admet-155	17	38	genital	genital	ADJ
admet-155	17	39	system	system	NOUN
admet-155	17	40	modulators	modulator	NOUN
admet-155	17	41	or	or	CCONJ
admet-155	17	42	drugs	drug	NOUN
admet-155	17	43	of	of	ADP
admet-155	17	44	central	central	ADJ
admet-155	17	45	/	/	SYM
admet-155	17	46	vegetative	vegetative	ADJ
admet-155	17	47	nervous	nervous	ADJ
admet-155	17	48	system	system	NOUN
admet-155	18	1	[	[	X
admet-155	18	2	14−16	14−16	X
admet-155	18	3	]	]	PUNCT
admet-155	18	4	.	.	PUNCT
admet-155	19	1	permeation	permeation	NOUN
admet-155	19	2	through	through	ADP
admet-155	19	3	the	the	DET
admet-155	19	4	skin	skin	NOUN
admet-155	19	5	of	of	ADP
admet-155	19	6	micronized	micronized	ADJ
admet-155	19	7	and	and	CCONJ
admet-155	19	8	nanonized	nanonize	VERB
admet-155	19	9	(	(	PUNCT
admet-155	19	10	s)-alaptide	s)-alaptide	PUNCT
admet-155	19	11	from	from	ADP
admet-155	19	12	semisolid	semisolid	NOUN
admet-155	19	13	formulations	formulation	NOUN
admet-155	19	14	was	be	AUX
admet-155	19	15	investigated	investigate	VERB
admet-155	19	16	recently	recently	ADV
admet-155	19	17	[	[	X
admet-155	19	18	17	17	NUM
admet-155	19	19	]	]	PUNCT
admet-155	19	20	,	,	PUNCT
admet-155	19	21	and	and	CCONJ
admet-155	19	22	the	the	DET
admet-155	19	23	transdermal	transdermal	ADJ
admet-155	19	24	modifying	modify	VERB
admet-155	19	25	effect	effect	NOUN
admet-155	19	26	of	of	ADP
admet-155	19	27	micronized	micronized	ADJ
admet-155	19	28	and	and	CCONJ
admet-155	19	29	nanonized	nanonize	VERB
admet-155	19	30	(	(	PUNCT
admet-155	19	31	s)-alaptide	s)-alaptide	PUNCT
admet-155	19	32	was	be	AUX
admet-155	19	33	also	also	ADV
admet-155	19	34	described	describe	VERB
admet-155	20	1	[	[	X
admet-155	20	2	14−16,18,19	14−16,18,19	NUM
admet-155	20	3	]	]	PUNCT
admet-155	20	4	.	.	PUNCT
admet-155	21	1	it	it	PRON
admet-155	21	2	was	be	AUX
admet-155	21	3	found	find	VERB
admet-155	21	4	that	that	SCONJ
admet-155	21	5	enhancers	enhancer	NOUN
admet-155	21	6	can	can	AUX
admet-155	21	7	become	become	VERB
admet-155	21	8	retardants	retardant	NOUN
admet-155	21	9	in	in	ADP
admet-155	21	10	different	different	ADJ
admet-155	21	11	formulation	formulation	NOUN
admet-155	21	12	environments	environment	NOUN
admet-155	21	13	or	or	CCONJ
admet-155	21	14	when	when	SCONJ
admet-155	21	15	different	different	ADJ
admet-155	21	16	particle	particle	NOUN
admet-155	21	17	sizes	size	NOUN
admet-155	21	18	were	be	AUX
admet-155	21	19	used	use	VERB
admet-155	21	20	and	and	CCONJ
admet-155	21	21	vice	vice	ADV
admet-155	21	22	versa	versa	ADV
admet-155	21	23	.	.	PUNCT
admet-155	22	1	since	since	SCONJ
admet-155	22	2	modifiers	modifier	NOUN
admet-155	22	3	influence	influence	NOUN
admet-155	22	4	drug	drug	NOUN
admet-155	22	5	delivery	delivery	NOUN
admet-155	22	6	,	,	PUNCT
admet-155	22	7	further	further	ADJ
admet-155	22	8	exploration	exploration	NOUN
admet-155	22	9	of	of	ADP
admet-155	22	10	these	these	DET
admet-155	22	11	compounds	compound	NOUN
admet-155	22	12	is	be	AUX
admet-155	22	13	required	require	VERB
admet-155	22	14	to	to	PART
admet-155	22	15	understand	understand	VERB
admet-155	22	16	their	their	PRON
admet-155	22	17	modifying	modify	VERB
admet-155	22	18	action	action	NOUN
admet-155	22	19	on	on	ADP
admet-155	22	20	the	the	DET
admet-155	22	21	properties	property	NOUN
admet-155	22	22	of	of	ADP
admet-155	22	23	the	the	DET
admet-155	22	24	skin	skin	NOUN
admet-155	22	25	.	.	PUNCT
admet-155	23	1	today	today	NOUN
admet-155	23	2	more	more	ADJ
admet-155	23	3	than	than	ADP
admet-155	23	4	50	50	NUM
admet-155	23	5	%	%	NOUN
admet-155	23	6	of	of	ADP
admet-155	23	7	marketed	market	VERB
admet-155	23	8	drugs	drug	NOUN
admet-155	23	9	are	be	AUX
admet-155	23	10	chiral	chiral	ADJ
admet-155	23	11	.	.	PUNCT
admet-155	24	1	it	it	PRON
admet-155	24	2	has	have	AUX
admet-155	24	3	been	be	AUX
admet-155	24	4	well	well	ADV
admet-155	24	5	recognized	recognize	VERB
admet-155	24	6	that	that	SCONJ
admet-155	24	7	the	the	DET
admet-155	24	8	stereochemistry	stereochemistry	NOUN
admet-155	24	9	of	of	ADP
admet-155	24	10	chiral	chiral	ADJ
admet-155	24	11	drugs	drug	NOUN
admet-155	24	12	has	have	VERB
admet-155	24	13	a	a	DET
admet-155	24	14	major	major	ADJ
admet-155	24	15	influence	influence	NOUN
admet-155	24	16	on	on	ADP
admet-155	24	17	their	their	PRON
admet-155	24	18	pharmacological	pharmacological	NOUN
admet-155	24	19	,	,	PUNCT
admet-155	24	20	pharmacokinetic	pharmacokinetic	ADJ
admet-155	24	21	and	and	CCONJ
admet-155	24	22	toxicological	toxicological	ADJ
admet-155	24	23	actions	action	NOUN
admet-155	24	24	.	.	PUNCT
admet-155	25	1	studies	study	NOUN
admet-155	25	2	on	on	ADP
admet-155	25	3	enantiomeric	enantiomeric	ADJ
admet-155	25	4	differences	difference	NOUN
admet-155	25	5	in	in	ADP
admet-155	25	6	the	the	DET
admet-155	25	7	percutaneous	percutaneous	ADJ
admet-155	25	8	permeation	permeation	NOUN
admet-155	25	9	of	of	ADP
admet-155	25	10	chiral	chiral	ADJ
admet-155	25	11	compounds	compound	NOUN
admet-155	25	12	have	have	AUX
admet-155	25	13	been	be	AUX
admet-155	25	14	actively	actively	ADV
admet-155	25	15	pursued	pursue	VERB
admet-155	25	16	in	in	ADP
admet-155	25	17	recent	recent	ADJ
admet-155	25	18	years	year	NOUN
admet-155	25	19	.	.	PUNCT
admet-155	26	1	stratum	stratum	PROPN
admet-155	26	2	corneum	corneum	PROPN
admet-155	26	3	,	,	PUNCT
admet-155	26	4	the	the	DET
admet-155	26	5	rate	rate	NOUN
admet-155	26	6	-	-	PUNCT
admet-155	26	7	limiting	limit	VERB
admet-155	26	8	barrier	barrier	NOUN
admet-155	26	9	in	in	ADP
admet-155	26	10	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-155	26	11	mailto:josef.jampilek@gmail.com	mailto:josef.jampilek@gmail.com	PROPN
admet-155	26	12	mailto:josef.jampilek@gmail.com	mailto:josef.jampilek@gmail.com	PROPN
admet-155	26	13	admet	admet	PROPN
admet-155	26	14	&	&	CCONJ
admet-155	26	15	dmpk	dmpk	PROPN
admet-155	26	16	2(4	2(4	NUM
admet-155	26	17	)	)	PUNCT
admet-155	26	18	(	(	PUNCT
admet-155	26	19	2014	2014	NUM
admet-155	26	20	)	)	PUNCT
admet-155	26	21	248	248	NUM
admet-155	26	22	-	-	SYM
admet-155	26	23	253	253	NUM
admet-155	26	24	rutin	rutin	NOUN
admet-155	26	25	permeation	permeation	NOUN
admet-155	26	26	enhancement	enhancement	NOUN
admet-155	26	27	by	by	ADP
admet-155	26	28	alaptide	alaptide	ADJ
admet-155	26	29	enantiomers	enantiomer	NOUN
admet-155	26	30	doi	doi	NOUN
admet-155	26	31	:	:	PUNCT
admet-155	26	32	10.5599	10.5599	NUM
admet-155	26	33	/	/	SYM
admet-155	26	34	admet.2.4.155	admet.2.4.155	NUM
admet-155	26	35	249	249	NUM
admet-155	26	36	transdermal	transdermal	ADJ
admet-155	26	37	permeation	permeation	NOUN
admet-155	26	38	,	,	PUNCT
admet-155	26	39	is	be	AUX
admet-155	26	40	made	make	VERB
admet-155	26	41	up	up	ADP
admet-155	26	42	mainly	mainly	ADV
admet-155	26	43	of	of	ADP
admet-155	26	44	keratin	keratin	NOUN
admet-155	26	45	and	and	CCONJ
admet-155	26	46	ceramides	ceramide	NOUN
admet-155	26	47	,	,	PUNCT
admet-155	26	48	which	which	PRON
admet-155	26	49	could	could	AUX
admet-155	26	50	potentially	potentially	ADV
admet-155	26	51	provide	provide	VERB
admet-155	26	52	chiral	chiral	ADJ
admet-155	26	53	environment	environment	NOUN
admet-155	26	54	.	.	PUNCT
admet-155	27	1	transdermal	transdermal	ADJ
admet-155	27	2	delivery	delivery	NOUN
admet-155	27	3	is	be	AUX
admet-155	27	4	facilitated	facilitate	VERB
admet-155	27	5	by	by	ADP
admet-155	27	6	the	the	DET
admet-155	27	7	presence	presence	NOUN
admet-155	27	8	of	of	ADP
admet-155	27	9	penetration	penetration	NOUN
admet-155	27	10	enhancers	enhancer	NOUN
admet-155	27	11	,	,	PUNCT
admet-155	27	12	which	which	PRON
admet-155	27	13	act	act	VERB
admet-155	27	14	primarily	primarily	ADV
admet-155	27	15	by	by	ADP
admet-155	27	16	altering	alter	VERB
admet-155	27	17	the	the	DET
admet-155	27	18	diffusion	diffusion	NOUN
admet-155	27	19	by	by	ADP
admet-155	27	20	disrupting	disrupt	VERB
admet-155	27	21	the	the	DET
admet-155	27	22	highly	highly	ADV
admet-155	27	23	ordered	order	VERB
admet-155	27	24	membrane	membrane	NOUN
admet-155	27	25	structure	structure	NOUN
admet-155	27	26	or	or	CCONJ
admet-155	27	27	by	by	ADP
admet-155	27	28	affecting	affect	VERB
admet-155	27	29	the	the	DET
admet-155	27	30	partitioning	partition	VERB
admet-155	27	31	behaviour	behaviour	NOUN
admet-155	27	32	of	of	ADP
admet-155	27	33	the	the	DET
admet-155	27	34	diffusant	diffusant	NOUN
admet-155	27	35	molecules	molecule	NOUN
admet-155	27	36	.	.	PUNCT
admet-155	28	1	enantioselective	enantioselective	ADJ
admet-155	28	2	permeation	permeation	NOUN
admet-155	28	3	was	be	AUX
admet-155	28	4	observed	observe	VERB
admet-155	28	5	with	with	ADP
admet-155	28	6	some	some	DET
admet-155	28	7	chiral	chiral	ADJ
admet-155	28	8	excipients	excipient	NOUN
admet-155	28	9	,	,	PUNCT
admet-155	28	10	including	include	VERB
admet-155	28	11	,	,	PUNCT
admet-155	28	12	for	for	ADP
admet-155	28	13	example	example	NOUN
admet-155	28	14	,	,	PUNCT
admet-155	28	15	terpene	terpene	NOUN
admet-155	28	16	enhancers	enhancer	NOUN
admet-155	28	17	[	[	X
admet-155	28	18	20−22	20−22	X
admet-155	28	19	]	]	PUNCT
admet-155	28	20	.	.	PUNCT
admet-155	29	1	based	base	VERB
admet-155	29	2	on	on	ADP
admet-155	29	3	the	the	DET
admet-155	29	4	above	above	ADJ
admet-155	29	5	mentioned	mention	VERB
admet-155	29	6	facts	fact	NOUN
admet-155	29	7	and	and	CCONJ
admet-155	29	8	the	the	DET
admet-155	29	9	excellent	excellent	ADJ
admet-155	29	10	enhancement	enhancement	NOUN
admet-155	29	11	effect	effect	NOUN
admet-155	29	12	of	of	ADP
admet-155	29	13	(	(	PUNCT
admet-155	29	14	s)-alaptide	s)-alaptide	PUNCT
admet-155	29	15	[	[	X
admet-155	29	16	14−16	14−16	X
admet-155	29	17	]	]	PUNCT
admet-155	29	18	,	,	PUNCT
admet-155	29	19	(	(	PUNCT
admet-155	29	20	r)-alaptide	r)-alaptide	NUM
admet-155	29	21	was	be	AUX
admet-155	29	22	prepared	prepare	VERB
admet-155	29	23	,	,	PUNCT
admet-155	29	24	and	and	CCONJ
admet-155	29	25	both	both	DET
admet-155	29	26	enantiomers	enantiomer	NOUN
admet-155	29	27	were	be	AUX
admet-155	29	28	tested	test	VERB
admet-155	29	29	by	by	ADP
admet-155	29	30	means	mean	NOUN
admet-155	29	31	of	of	ADP
admet-155	29	32	rapid	rapid	ADJ
admet-155	29	33	screening	screening	NOUN
admet-155	29	34	for	for	ADP
admet-155	29	35	their	their	PRON
admet-155	29	36	ability	ability	NOUN
admet-155	29	37	to	to	PART
admet-155	29	38	modify	modify	VERB
admet-155	29	39	the	the	DET
admet-155	29	40	skin	skin	NOUN
admet-155	29	41	barrier	barrier	NOUN
admet-155	29	42	properties	property	NOUN
admet-155	29	43	.	.	PUNCT
admet-155	30	1	bioflavonoid	bioflavonoid	PROPN
admet-155	30	2	glycoside	glycoside	NOUN
admet-155	30	3	rutin	rutin	NOUN
admet-155	30	4	,	,	PUNCT
admet-155	30	5	2-(3,4	2-(3,4	NOUN
admet-155	30	6	-	-	PUNCT
admet-155	30	7	dihydroxyphenyl)-5,7	dihydroxyphenyl)-5,7	NOUN
admet-155	30	8	-	-	PUNCT
admet-155	30	9	dihydroxy-4oxo-4h	dihydroxy-4oxo-4h	ADJ
admet-155	30	10	-	-	PUNCT
admet-155	30	11	chromen-3	chromen-3	NOUN
admet-155	30	12	-	-	PUNCT
admet-155	30	13	yl	yl	NOUN
admet-155	30	14	6	6	NUM
admet-155	30	15	-	-	PUNCT
admet-155	30	16	o-(6	o-(6	NUM
admet-155	30	17	-	-	PUNCT
admet-155	30	18	deoxy	deoxy	VERB
admet-155	30	19	-	-	PUNCT
admet-155	30	20	α	α	NOUN
admet-155	30	21	-	-	PUNCT
admet-155	30	22	l	l	NOUN
admet-155	30	23	-	-	PUNCT
admet-155	30	24	mannopyranosyl)-β	mannopyranosyl)-β	NOUN
admet-155	30	25	-	-	PUNCT
admet-155	30	26	d	d	NOUN
admet-155	30	27	-	-	PUNCT
admet-155	30	28	glucopyranoside	glucopyranoside	NOUN
admet-155	30	29	,	,	PUNCT
admet-155	30	30	see	see	VERB
admet-155	30	31	fig	fig	NOUN
admet-155	30	32	.	.	PUNCT
admet-155	31	1	1	1	NUM
admet-155	31	2	,	,	PUNCT
admet-155	31	3	was	be	AUX
admet-155	31	4	chosen	choose	VERB
admet-155	31	5	as	as	ADP
admet-155	31	6	an	an	DET
admet-155	31	7	model	model	NOUN
admet-155	31	8	compound	compound	NOUN
admet-155	31	9	,	,	PUNCT
admet-155	31	10	since	since	SCONJ
admet-155	31	11	rutin	rutin	NOUN
admet-155	31	12	is	be	AUX
admet-155	31	13	one	one	NUM
admet-155	31	14	of	of	ADP
admet-155	31	15	the	the	DET
admet-155	31	16	most	most	ADV
admet-155	31	17	often	often	ADV
admet-155	31	18	used	use	VERB
admet-155	31	19	drugs	drug	NOUN
admet-155	31	20	for	for	ADP
admet-155	31	21	decreasing	decrease	VERB
admet-155	31	22	capillary	capillary	ADJ
admet-155	31	23	permeability	permeability	NOUN
admet-155	31	24	and	and	CCONJ
admet-155	31	25	for	for	ADP
admet-155	31	26	treatment	treatment	NOUN
admet-155	31	27	of	of	ADP
admet-155	31	28	haemorrhoids	haemorrhoid	NOUN
admet-155	31	29	,	,	PUNCT
admet-155	31	30	varicosis	varicosis	NOUN
admet-155	31	31	and	and	CCONJ
admet-155	31	32	microangiopathy	microangiopathy	ADJ
admet-155	32	1	[	[	X
admet-155	32	2	23	23	NUM
admet-155	32	3	]	]	PUNCT
admet-155	32	4	.	.	PUNCT
admet-155	33	1	enhanced	enhance	VERB
admet-155	33	2	permeation	permeation	NOUN
admet-155	33	3	through	through	ADP
admet-155	33	4	the	the	DET
admet-155	33	5	skin	skin	NOUN
admet-155	33	6	and	and	CCONJ
admet-155	33	7	higher	high	ADJ
admet-155	33	8	availability	availability	NOUN
admet-155	33	9	of	of	ADP
admet-155	33	10	the	the	DET
admet-155	33	11	compound	compound	NOUN
admet-155	33	12	would	would	AUX
admet-155	33	13	be	be	AUX
admet-155	33	14	favourable	favourable	ADJ
admet-155	33	15	for	for	ADP
admet-155	33	16	the	the	DET
admet-155	33	17	treatment	treatment	NOUN
admet-155	33	18	of	of	ADP
admet-155	33	19	vascular	vascular	ADJ
admet-155	33	20	wall	wall	NOUN
admet-155	33	21	fragility	fragility	NOUN
admet-155	33	22	.	.	PUNCT
admet-155	34	1	within	within	ADP
admet-155	34	2	this	this	DET
admet-155	34	3	study	study	NOUN
admet-155	34	4	the	the	DET
admet-155	34	5	permeation	permeation	NOUN
admet-155	34	6	of	of	ADP
admet-155	34	7	rutin	rutin	NOUN
admet-155	34	8	from	from	ADP
admet-155	34	9	carboxymethyl	carboxymethyl	NOUN
admet-155	34	10	cellulose	cellulose	NOUN
admet-155	34	11	gel	gel	NOUN
admet-155	34	12	and	and	CCONJ
admet-155	34	13	subsequently	subsequently	ADV
admet-155	34	14	the	the	DET
admet-155	34	15	permeation	permeation	NOUN
admet-155	34	16	of	of	ADP
admet-155	34	17	rutin	rutin	NOUN
admet-155	34	18	with	with	ADP
admet-155	34	19	the	the	DET
admet-155	34	20	addition	addition	NOUN
admet-155	34	21	of	of	ADP
admet-155	34	22	the	the	DET
admet-155	34	23	individual	individual	ADJ
admet-155	34	24	enantiomers	enantiomer	NOUN
admet-155	34	25	of	of	ADP
admet-155	34	26	alaptide	alaptide	NOUN
admet-155	34	27	as	as	ADP
admet-155	34	28	modifiers	modifier	NOUN
admet-155	34	29	of	of	ADP
admet-155	34	30	transdermal	transdermal	ADJ
admet-155	34	31	permeation	permeation	NOUN
admet-155	34	32	from	from	ADP
admet-155	34	33	the	the	DET
admet-155	34	34	same	same	ADJ
admet-155	34	35	formulation	formulation	NOUN
admet-155	34	36	are	be	AUX
admet-155	34	37	investigated	investigate	VERB
admet-155	34	38	.	.	PUNCT
admet-155	35	1	flavonoids	flavonoid	NOUN
admet-155	35	2	(	(	PUNCT
admet-155	35	3	bioflavonoids	bioflavonoid	NOUN
admet-155	35	4	,	,	PUNCT
admet-155	35	5	vitamin	vitamin	NOUN
admet-155	35	6	p	p	NOUN
admet-155	35	7	)	)	PUNCT
admet-155	35	8	are	be	AUX
admet-155	35	9	a	a	DET
admet-155	35	10	class	class	NOUN
admet-155	35	11	of	of	ADP
admet-155	35	12	plant	plant	NOUN
admet-155	35	13	secondary	secondary	ADJ
admet-155	35	14	phenolic	phenolic	ADJ
admet-155	35	15	metabolites	metabolite	NOUN
admet-155	35	16	.	.	PUNCT
admet-155	36	1	today	today	NOUN
admet-155	36	2	more	more	ADJ
admet-155	36	3	than	than	ADP
admet-155	36	4	4000	4000	NUM
admet-155	36	5	flavonoid	flavonoid	NOUN
admet-155	36	6	-	-	PUNCT
admet-155	36	7	based	base	VERB
admet-155	36	8	compounds	compound	NOUN
admet-155	36	9	were	be	AUX
admet-155	36	10	described	describe	VERB
admet-155	36	11	[	[	PUNCT
admet-155	36	12	24,25	24,25	NUM
admet-155	36	13	]	]	PUNCT
admet-155	36	14	.	.	PUNCT
admet-155	37	1	flavonoids	flavonoid	NOUN
admet-155	37	2	are	be	AUX
admet-155	37	3	glycosides	glycoside	NOUN
admet-155	37	4	containing	contain	VERB
admet-155	37	5	aglycone	aglycone	NOUN
admet-155	37	6	derived	derive	VERB
admet-155	37	7	from	from	ADP
admet-155	37	8	benzopyran	benzopyran	NOUN
admet-155	37	9	(	(	PUNCT
admet-155	37	10	chromene	chromene	PROPN
admet-155	37	11	)	)	PUNCT
admet-155	37	12	with	with	ADP
admet-155	37	13	lateral	lateral	ADJ
admet-155	37	14	phenyl	phenyl	NOUN
admet-155	37	15	in	in	ADP
admet-155	37	16	the	the	DET
admet-155	37	17	positions	position	NOUN
admet-155	37	18	c(2	c(2	PROPN
admet-155	37	19	)	)	PUNCT
admet-155	37	20	,	,	PUNCT
admet-155	37	21	c(3	c(3	NOUN
admet-155	37	22	)	)	PUNCT
admet-155	37	23	or	or	CCONJ
admet-155	37	24	c(4	c(4	PROPN
admet-155	37	25	)	)	PUNCT
admet-155	37	26	of	of	ADP
admet-155	37	27	the	the	DET
admet-155	37	28	benzopyran	benzopyran	ADJ
admet-155	37	29	scaffold	scaffold	NOUN
admet-155	37	30	.	.	PUNCT
admet-155	38	1	the	the	DET
admet-155	38	2	phenyl	phenyl	NOUN
admet-155	38	3	rings	ring	NOUN
admet-155	38	4	are	be	AUX
admet-155	38	5	marked	mark	VERB
admet-155	38	6	a	a	PRON
admet-155	38	7	and	and	CCONJ
admet-155	38	8	b	b	NOUN
admet-155	38	9	,	,	PUNCT
admet-155	38	10	and	and	CCONJ
admet-155	38	11	the	the	DET
admet-155	38	12	pyran	pyran	ADJ
admet-155	38	13	ring	ring	NOUN
admet-155	38	14	c	c	PROPN
admet-155	38	15	is	be	AUX
admet-155	38	16	ortho	ortho	PROPN
admet-155	38	17	-	-	PUNCT
admet-155	38	18	condensed	condense	VERB
admet-155	38	19	with	with	ADP
admet-155	38	20	the	the	DET
admet-155	38	21	ring	ring	NOUN
admet-155	38	22	a.	a.	NOUN
admet-155	38	23	in	in	ADP
admet-155	38	24	nature	nature	NOUN
admet-155	38	25	flavonoids	flavonoid	NOUN
admet-155	38	26	are	be	AUX
admet-155	38	27	substituted	substitute	VERB
admet-155	38	28	(	(	PUNCT
admet-155	38	29	especially	especially	ADV
admet-155	38	30	in	in	ADP
admet-155	38	31	position	position	NOUN
admet-155	38	32	3	3	NUM
admet-155	38	33	of	of	ADP
admet-155	38	34	the	the	DET
admet-155	38	35	benzopyran	benzopyran	ADJ
admet-155	38	36	scaffold	scaffold	NOUN
admet-155	38	37	)	)	PUNCT
admet-155	38	38	by	by	ADP
admet-155	38	39	various	various	ADJ
admet-155	38	40	sugars	sugar	NOUN
admet-155	38	41	and	and	CCONJ
admet-155	38	42	generate	generate	VERB
admet-155	38	43	flavonoid	flavonoid	NOUN
admet-155	38	44	glycoside	glycoside	NOUN
admet-155	38	45	.	.	PUNCT
admet-155	39	1	aglycone	aglycone	NOUN
admet-155	39	2	or	or	CCONJ
admet-155	39	3	the	the	DET
admet-155	39	4	glycosyl	glycosyl	NOUN
admet-155	39	5	group	group	NOUN
admet-155	39	6	can	can	AUX
admet-155	39	7	be	be	AUX
admet-155	39	8	substituted	substitute	VERB
admet-155	39	9	by	by	ADP
admet-155	39	10	a	a	DET
admet-155	39	11	hydroxyacid	hydroxyacid	NOUN
admet-155	39	12	[	[	X
admet-155	39	13	25,26	25,26	NUM
admet-155	39	14	]	]	X
admet-155	39	15	.	.	PUNCT
admet-155	40	1	both	both	PRON
admet-155	40	2	aglycone	aglycone	NOUN
admet-155	40	3	and	and	CCONJ
admet-155	40	4	glycosides	glycoside	NOUN
admet-155	40	5	have	have	VERB
admet-155	40	6	biological	biological	ADJ
admet-155	40	7	effects	effect	NOUN
admet-155	40	8	.	.	PUNCT
admet-155	41	1	bioflavonoids	bioflavonoid	NOUN
admet-155	41	2	normalize	normalize	VERB
admet-155	41	3	permeability	permeability	NOUN
admet-155	41	4	of	of	ADP
admet-155	41	5	capillaries	capillary	NOUN
admet-155	41	6	and	and	CCONJ
admet-155	41	7	remove	remove	VERB
admet-155	41	8	their	their	PRON
admet-155	41	9	fragility	fragility	NOUN
admet-155	41	10	;	;	PUNCT
admet-155	41	11	they	they	PRON
admet-155	41	12	have	have	VERB
admet-155	41	13	antihaemorrhagic	antihaemorrhagic	ADJ
admet-155	41	14	and	and	CCONJ
admet-155	41	15	anti	anti	ADJ
admet-155	41	16	-	-	ADJ
admet-155	41	17	edematous	edematous	ADJ
admet-155	41	18	effects	effect	NOUN
admet-155	42	1	[	[	X
admet-155	42	2	25−28	25−28	X
admet-155	42	3	]	]	X
admet-155	42	4	.	.	PUNCT
admet-155	43	1	also	also	ADV
admet-155	43	2	antibacterial	antibacterial	ADJ
admet-155	43	3	,	,	PUNCT
admet-155	43	4	antioxidant	antioxidant	ADJ
admet-155	43	5	and	and	CCONJ
admet-155	43	6	anti	anti	ADJ
admet-155	43	7	-	-	ADJ
admet-155	43	8	inflammatory	inflammatory	ADJ
admet-155	43	9	activities	activity	NOUN
admet-155	43	10	are	be	AUX
admet-155	43	11	typical	typical	ADJ
admet-155	43	12	for	for	ADP
admet-155	43	13	them	they	PRON
admet-155	44	1	[	[	X
admet-155	44	2	25−28	25−28	NOUN
admet-155	44	3	]	]	X
admet-155	44	4	.	.	PUNCT
admet-155	45	1	bioflavonoids	bioflavonoid	NOUN
admet-155	45	2	are	be	AUX
admet-155	45	3	used	use	VERB
admet-155	45	4	as	as	ADP
admet-155	45	5	venopharmaceuticals	venopharmaceutical	NOUN
admet-155	45	6	,	,	PUNCT
admet-155	45	7	i.e.	i.e.	X
admet-155	45	8	drugs	drug	NOUN
admet-155	45	9	for	for	ADP
admet-155	45	10	the	the	DET
admet-155	45	11	treatment	treatment	NOUN
admet-155	45	12	of	of	ADP
admet-155	45	13	chronic	chronic	ADJ
admet-155	45	14	venous	venous	ADJ
admet-155	45	15	insufficiency	insufficiency	NOUN
admet-155	45	16	,	,	PUNCT
admet-155	45	17	superficial	superficial	ADJ
admet-155	45	18	thrombophlebitis	thrombophlebitis	NOUN
admet-155	45	19	and	and	CCONJ
admet-155	45	20	haemorrhoids	haemorrhoid	NOUN
admet-155	45	21	.	.	PUNCT
admet-155	46	1	they	they	PRON
admet-155	46	2	can	can	AUX
admet-155	46	3	be	be	AUX
admet-155	46	4	applied	apply	VERB
admet-155	46	5	locally	locally	ADV
admet-155	46	6	for	for	ADP
admet-155	46	7	the	the	DET
admet-155	46	8	treatment	treatment	NOUN
admet-155	46	9	of	of	ADP
admet-155	46	10	dermatomicroangiopathy	dermatomicroangiopathy	ADJ
admet-155	46	11	,	,	PUNCT
admet-155	46	12	periphlebitis	periphlebiti	NOUN
admet-155	46	13	,	,	PUNCT
admet-155	46	14	haematomas	haematoma	NOUN
admet-155	46	15	and	and	CCONJ
admet-155	46	16	traumatic	traumatic	ADJ
admet-155	46	17	oedema	oedema	NOUN
admet-155	46	18	[	[	X
admet-155	46	19	28	28	NUM
admet-155	46	20	]	]	PUNCT
admet-155	46	21	.	.	PUNCT
admet-155	47	1	figure	figure	NOUN
admet-155	47	2	1	1	NUM
admet-155	47	3	.	.	PUNCT
admet-155	48	1	structures	structure	NOUN
admet-155	48	2	of	of	ADP
admet-155	48	3	investigated	investigate	VERB
admet-155	48	4	compounds	compound	NOUN
admet-155	48	5	.	.	PUNCT
admet-155	49	1	experimental	experimental	ADJ
admet-155	49	2	preparation	preparation	NOUN
admet-155	49	3	of	of	ADP
admet-155	49	4	alaptide	alaptide	NOUN
admet-155	49	5	both	both	DET
admet-155	49	6	alaptide	alaptide	ADJ
admet-155	49	7	enantiomers	enantiomer	NOUN
admet-155	49	8	were	be	AUX
admet-155	49	9	synthesized	synthesize	VERB
admet-155	49	10	by	by	ADP
admet-155	49	11	the	the	DET
admet-155	49	12	standard	standard	ADJ
admet-155	49	13	process	process	NOUN
admet-155	49	14	[	[	X
admet-155	49	15	29	29	NUM
admet-155	49	16	]	]	PUNCT
admet-155	49	17	and	and	CCONJ
admet-155	49	18	characterized	characterize	VERB
admet-155	49	19	[	[	X
admet-155	49	20	30	30	NUM
admet-155	49	21	]	]	PUNCT
admet-155	49	22	.	.	PUNCT
admet-155	50	1	the	the	DET
admet-155	50	2	specific	specific	ADJ
admet-155	50	3	optical	optical	ADJ
admet-155	50	4	rotation	rotation	NOUN
admet-155	50	5	of	of	ADP
admet-155	50	6	0.2	0.2	NUM
admet-155	50	7	mol	mol	NOUN
admet-155	50	8	/	/	SYM
admet-155	50	9	l	l	NOUN
admet-155	50	10	methanolic	methanolic	NOUN
admet-155	50	11	solution	solution	NOUN
admet-155	50	12	is	be	AUX
admet-155	50	13	[	[	X
admet-155	50	14	α]d	α]d	NOUN
admet-155	50	15	20	20	NUM
admet-155	50	16	=	=	SYM
admet-155	50	17	+21.2	+21.2	PROPN
admet-155	50	18	°	°	NOUN
admet-155	50	19	for	for	ADP
admet-155	50	20	the	the	DET
admet-155	50	21	(	(	PUNCT
admet-155	50	22	r)-enantiomer	r)-enantiomer	NOUN
admet-155	50	23	and	and	CCONJ
admet-155	50	24	[	[	X
admet-155	50	25	α]d	α]d	NOUN
admet-155	50	26	20	20	NUM
admet-155	50	27	=	=	PUNCT
admet-155	51	1	-21.2	-21.2	NOUN
admet-155	51	2	°	°	NOUN
admet-155	51	3	for	for	ADP
admet-155	51	4	the	the	DET
admet-155	51	5	(	(	PUNCT
admet-155	51	6	s)-enantiomer	s)-enantiomer	PROPN
admet-155	51	7	.	.	PUNCT
admet-155	52	1	the	the	DET
admet-155	52	2	melting	melting	NOUN
admet-155	52	3	point	point	NOUN
admet-155	52	4	of	of	ADP
admet-155	52	5	(	(	PUNCT
admet-155	52	6	s)-alaptide	s)-alaptide	PUNCT
admet-155	52	7	is	be	AUX
admet-155	52	8	232	232	NUM
admet-155	52	9	-	-	SYM
admet-155	52	10	234	234	NUM
admet-155	52	11	°	°	NOUN
admet-155	52	12	c	c	NOUN
admet-155	52	13	,	,	PUNCT
admet-155	52	14	while	while	SCONJ
admet-155	52	15	that	that	PRON
admet-155	52	16	of	of	ADP
admet-155	52	17	jampilek	jampilek	PROPN
admet-155	52	18	et	et	PROPN
admet-155	52	19	al	al	PROPN
admet-155	52	20	.	.	PROPN
admet-155	52	21	admet	admet	PROPN
admet-155	52	22	&	&	CCONJ
admet-155	52	23	dmpk	dmpk	PROPN
admet-155	52	24	2(4	2(4	NUM
admet-155	52	25	)	)	PUNCT
admet-155	52	26	(	(	PUNCT
admet-155	52	27	2014	2014	NUM
admet-155	52	28	)	)	PUNCT
admet-155	52	29	248	248	NUM
admet-155	52	30	-	-	SYM
admet-155	52	31	253	253	NUM
admet-155	52	32	250	250	NUM
admet-155	52	33	(	(	PUNCT
admet-155	52	34	r)-alaptide	r)-alaptide	NUM
admet-155	52	35	is	be	AUX
admet-155	52	36	230	230	NUM
admet-155	52	37	-	-	SYM
admet-155	52	38	232	232	NUM
admet-155	52	39	°	°	ADP
admet-155	52	40	c	c	NOUN
admet-155	52	41	.	.	PUNCT
admet-155	53	1	rutin	rutin	NOUN
admet-155	53	2	was	be	AUX
admet-155	53	3	purchased	purchase	VERB
admet-155	53	4	from	from	ADP
admet-155	53	5	sigma	sigma	NOUN
admet-155	53	6	,	,	PUNCT
admet-155	53	7	all	all	DET
admet-155	53	8	other	other	ADJ
admet-155	53	9	reagents	reagent	NOUN
admet-155	53	10	were	be	AUX
admet-155	53	11	purchased	purchase	VERB
admet-155	53	12	from	from	ADP
admet-155	53	13	aldrich	aldrich	PROPN
admet-155	53	14	and	and	CCONJ
admet-155	53	15	lach	lach	PROPN
admet-155	53	16	-	-	PUNCT
admet-155	53	17	ner	ner	NOUN
admet-155	53	18	.	.	PUNCT
admet-155	54	1	investigated	investigate	VERB
admet-155	54	2	semisolid	semisolid	NOUN
admet-155	54	3	formulations	formulation	NOUN
admet-155	54	4	the	the	DET
admet-155	54	5	composition	composition	NOUN
admet-155	54	6	of	of	ADP
admet-155	54	7	gel	gel	NOUN
admet-155	54	8	with	with	ADP
admet-155	54	9	10	10	NUM
admet-155	54	10	%	%	NOUN
admet-155	54	11	(	(	PUNCT
admet-155	54	12	w	w	NOUN
admet-155	54	13	/	/	SYM
admet-155	54	14	w	w	NOUN
admet-155	54	15	)	)	PUNCT
admet-155	54	16	rutin	rutin	NOUN
admet-155	54	17	was	be	AUX
admet-155	54	18	the	the	DET
admet-155	54	19	following	following	NOUN
admet-155	54	20	:	:	PUNCT
admet-155	54	21	rutin	rutin	NOUN
admet-155	54	22	10	10	NUM
admet-155	54	23	g	g	NOUN
admet-155	54	24	and	and	CCONJ
admet-155	54	25	carboxymethyl	carboxymethyl	NOUN
admet-155	54	26	cellulose	cellulose	NOUN
admet-155	54	27	gel	gel	NOUN
admet-155	54	28	(	(	PUNCT
admet-155	54	29	carboxymethyl	carboxymethyl	NOUN
admet-155	54	30	cellulose	cellulose	NOUN
admet-155	54	31	sodium	sodium	NOUN
admet-155	54	32	5	5	NUM
admet-155	54	33	g	g	NOUN
admet-155	54	34	,	,	PUNCT
admet-155	54	35	macrogol	macrogol	VERB
admet-155	54	36	300	300	NUM
admet-155	54	37	10	10	NUM
admet-155	54	38	g	g	NOUN
admet-155	54	39	,	,	PUNCT
admet-155	54	40	propylene	propylene	NOUN
admet-155	54	41	glycol	glycol	NOUN
admet-155	54	42	2.5	2.5	NUM
admet-155	54	43	g	g	NOUN
admet-155	54	44	,	,	PUNCT
admet-155	54	45	methylparaben	methylparaben	NOUN
admet-155	54	46	0.2	0.2	NUM
admet-155	54	47	g	g	NOUN
admet-155	54	48	,	,	PUNCT
admet-155	54	49	propylparaben	propylparaben	PROPN
admet-155	54	50	0.2	0.2	NUM
admet-155	54	51	g	g	NOUN
admet-155	54	52	and	and	CCONJ
admet-155	54	53	purified	purified	ADJ
admet-155	54	54	water	water	NOUN
admet-155	54	55	87.3	87.3	NUM
admet-155	54	56	g	g	NOUN
admet-155	54	57	)	)	PUNCT
admet-155	54	58	up	up	ADP
admet-155	54	59	to	to	PART
admet-155	54	60	100	100	NUM
admet-155	54	61	g.	g.	NOUN
admet-155	55	1	the	the	DET
admet-155	55	2	composition	composition	NOUN
admet-155	55	3	of	of	ADP
admet-155	55	4	gel	gel	NOUN
admet-155	55	5	with	with	ADP
admet-155	55	6	the	the	DET
admet-155	55	7	addition	addition	NOUN
admet-155	55	8	of	of	ADP
admet-155	55	9	alaptide	alaptide	ADJ
admet-155	55	10	1	1	NUM
admet-155	55	11	%	%	NOUN
admet-155	55	12	(	(	PUNCT
admet-155	55	13	w	w	NOUN
admet-155	55	14	/	/	SYM
admet-155	55	15	w	w	NOUN
admet-155	55	16	;	;	PUNCT
admet-155	55	17	in	in	ADP
admet-155	55	18	relation	relation	NOUN
admet-155	55	19	to	to	ADP
admet-155	55	20	rutin	rutin	NOUN
admet-155	55	21	amount	amount	NOUN
admet-155	55	22	)	)	PUNCT
admet-155	55	23	was	be	AUX
admet-155	55	24	the	the	DET
admet-155	55	25	following	following	NOUN
admet-155	55	26	:	:	PUNCT
admet-155	55	27	rutin	rutin	NOUN
admet-155	55	28	10	10	NUM
admet-155	55	29	g	g	NOUN
admet-155	55	30	,	,	PUNCT
admet-155	55	31	alaptide	alaptide	ADV
admet-155	55	32	0.1	0.1	NUM
admet-155	55	33	g	g	NOUN
admet-155	55	34	and	and	CCONJ
admet-155	55	35	carboxymethyl	carboxymethyl	PROPN
admet-155	55	36	cellulose	cellulose	NOUN
admet-155	55	37	gel	gel	NOUN
admet-155	55	38	up	up	ADP
admet-155	55	39	to	to	PART
admet-155	55	40	100	100	NUM
admet-155	55	41	g.	g.	NOUN
admet-155	55	42	in	in	ADP
admet-155	55	43	vitro	vitro	X
admet-155	55	44	transdermal	transdermal	ADJ
admet-155	55	45	permeation	permeation	NOUN
admet-155	55	46	experiments	experiment	NOUN
admet-155	55	47	skin	skin	NOUN
admet-155	55	48	samples	sample	NOUN
admet-155	55	49	were	be	AUX
admet-155	55	50	obtained	obtain	VERB
admet-155	55	51	from	from	ADP
admet-155	55	52	porcine	porcine	NOUN
admet-155	55	53	ear	ear	NOUN
admet-155	55	54	.	.	PUNCT
admet-155	56	1	full	full	ADJ
admet-155	56	2	thickness	thickness	NOUN
admet-155	56	3	skin	skin	NOUN
admet-155	56	4	was	be	AUX
admet-155	56	5	cut	cut	VERB
admet-155	56	6	in	in	ADP
admet-155	56	7	fragments	fragment	NOUN
admet-155	56	8	and	and	CCONJ
admet-155	56	9	stored	store	VERB
admet-155	56	10	at	at	ADP
admet-155	56	11	−20	−20	PROPN
admet-155	56	12	°	°	ADP
admet-155	56	13	c	c	NOUN
admet-155	56	14	until	until	ADP
admet-155	56	15	utilized	utilize	VERB
admet-155	56	16	.	.	PUNCT
admet-155	57	1	skin	skin	NOUN
admet-155	57	2	samples	sample	NOUN
admet-155	57	3	were	be	AUX
admet-155	57	4	slowly	slowly	ADV
admet-155	57	5	thawed	thaw	VERB
admet-155	57	6	(	(	PUNCT
admet-155	57	7	at	at	ADP
admet-155	57	8	4	4	NUM
admet-155	57	9	°	°	NOUN
admet-155	57	10	c	c	NOUN
admet-155	57	11	overnight	overnight	ADV
admet-155	57	12	and	and	CCONJ
admet-155	57	13	then	then	ADV
admet-155	57	14	at	at	ADP
admet-155	57	15	ambient	ambient	ADJ
admet-155	57	16	temperature	temperature	NOUN
admet-155	57	17	)	)	PUNCT
admet-155	57	18	before	before	ADP
admet-155	57	19	each	each	DET
admet-155	57	20	experiment	experiment	NOUN
admet-155	57	21	.	.	PUNCT
admet-155	58	1	the	the	DET
admet-155	58	2	permeation	permeation	NOUN
admet-155	58	3	enhancing	enhance	VERB
admet-155	58	4	effect	effect	NOUN
admet-155	58	5	of	of	ADP
admet-155	58	6	both	both	DET
admet-155	58	7	alaptide	alaptide	ADJ
admet-155	58	8	enantiomers	enantiomer	NOUN
admet-155	58	9	was	be	AUX
admet-155	58	10	evaluated	evaluate	VERB
admet-155	58	11	in	in	ADP
admet-155	58	12	vitro	vitro	NOUN
admet-155	58	13	,	,	PUNCT
admet-155	58	14	using	use	VERB
admet-155	58	15	a	a	DET
admet-155	58	16	vertical	vertical	ADJ
admet-155	58	17	franz	franz	NOUN
admet-155	58	18	diffusion	diffusion	NOUN
admet-155	58	19	cell	cell	NOUN
admet-155	58	20	(	(	PUNCT
admet-155	58	21	ses	ses	INTJ
admet-155	58	22	–	–	PUNCT
admet-155	58	23	analytical	analytical	ADJ
admet-155	58	24	systems	system	NOUN
admet-155	58	25	,	,	PUNCT
admet-155	58	26	germany	germany	PROPN
admet-155	58	27	)	)	PUNCT
admet-155	58	28	with	with	ADP
admet-155	58	29	a	a	DET
admet-155	58	30	donor	donor	NOUN
admet-155	58	31	surface	surface	NOUN
admet-155	58	32	area	area	NOUN
admet-155	58	33	of	of	ADP
admet-155	58	34	0.6359	0.6359	NUM
admet-155	58	35	cm2	cm2	NOUN
admet-155	58	36	and	and	CCONJ
admet-155	58	37	a	a	DET
admet-155	58	38	receptor	receptor	NOUN
admet-155	58	39	volume	volume	NOUN
admet-155	58	40	of	of	ADP
admet-155	58	41	5.2	5.2	NUM
admet-155	58	42	ml	ml	NOUN
admet-155	58	43	.	.	PUNCT
admet-155	59	1	the	the	DET
admet-155	59	2	skin	skin	NOUN
admet-155	59	3	was	be	AUX
admet-155	59	4	mounted	mount	VERB
admet-155	59	5	between	between	ADP
admet-155	59	6	the	the	DET
admet-155	59	7	donor	donor	NOUN
admet-155	59	8	and	and	CCONJ
admet-155	59	9	receptor	receptor	NOUN
admet-155	59	10	compartments	compartment	NOUN
admet-155	59	11	of	of	ADP
admet-155	59	12	the	the	DET
admet-155	59	13	franz	franz	NOUN
admet-155	59	14	diffusion	diffusion	NOUN
admet-155	59	15	cell	cell	NOUN
admet-155	59	16	with	with	ADP
admet-155	59	17	the	the	DET
admet-155	59	18	epidermal	epidermal	ADJ
admet-155	59	19	side	side	NOUN
admet-155	59	20	up	up	ADP
admet-155	59	21	.	.	PUNCT
admet-155	60	1	the	the	DET
admet-155	60	2	receptor	receptor	NOUN
admet-155	60	3	compartment	compartment	NOUN
admet-155	60	4	was	be	AUX
admet-155	60	5	filled	fill	VERB
admet-155	60	6	with	with	ADP
admet-155	60	7	phosphate	phosphate	ADJ
admet-155	60	8	buffered	buffer	VERB
admet-155	60	9	saline	saline	NOUN
admet-155	60	10	(	(	PUNCT
admet-155	60	11	ph	ph	NOUN
admet-155	60	12	7.4	7.4	NUM
admet-155	60	13	)	)	PUNCT
admet-155	60	14	and	and	CCONJ
admet-155	60	15	maintained	maintain	VERB
admet-155	60	16	at	at	ADP
admet-155	60	17	34.0±0.5	34.0±0.5	NUM
admet-155	60	18	°	°	NOUN
admet-155	60	19	c	c	NOUN
admet-155	60	20	,	,	PUNCT
admet-155	60	21	using	use	VERB
admet-155	60	22	a	a	DET
admet-155	60	23	circulating	circulate	VERB
admet-155	60	24	water	water	NOUN
admet-155	60	25	bath	bath	NOUN
admet-155	60	26	.	.	PUNCT
admet-155	61	1	the	the	DET
admet-155	61	2	receptor	receptor	NOUN
admet-155	61	3	compartment	compartment	NOUN
admet-155	61	4	content	content	NOUN
admet-155	61	5	was	be	AUX
admet-155	61	6	continuously	continuously	ADV
admet-155	61	7	stirred	stir	VERB
admet-155	61	8	using	use	VERB
admet-155	61	9	a	a	DET
admet-155	61	10	magnetic	magnetic	ADJ
admet-155	61	11	stirring	stirring	NOUN
admet-155	61	12	bar	bar	NOUN
admet-155	61	13	.	.	PUNCT
admet-155	62	1	the	the	DET
admet-155	62	2	skin	skin	NOUN
admet-155	62	3	was	be	AUX
admet-155	62	4	kept	keep	VERB
admet-155	62	5	in	in	ADP
admet-155	62	6	contact	contact	NOUN
admet-155	62	7	with	with	ADP
admet-155	62	8	the	the	DET
admet-155	62	9	receptor	receptor	NOUN
admet-155	62	10	phase	phase	NOUN
admet-155	62	11	for	for	ADP
admet-155	62	12	0.5	0.5	NUM
admet-155	62	13	h	h	NOUN
admet-155	62	14	prior	prior	ADV
admet-155	62	15	to	to	ADP
admet-155	62	16	the	the	DET
admet-155	62	17	experiment	experiment	NOUN
admet-155	62	18	.	.	PUNCT
admet-155	63	1	the	the	DET
admet-155	63	2	investigated	investigate	VERB
admet-155	63	3	gel	gel	NOUN
admet-155	63	4	formulations	formulation	NOUN
admet-155	63	5	were	be	AUX
admet-155	63	6	applied	apply	VERB
admet-155	63	7	to	to	ADP
admet-155	63	8	the	the	DET
admet-155	63	9	skin	skin	NOUN
admet-155	63	10	surface	surface	NOUN
admet-155	63	11	as	as	ADP
admet-155	63	12	a	a	DET
admet-155	63	13	donor	donor	NOUN
admet-155	63	14	sample	sample	NOUN
admet-155	63	15	,	,	PUNCT
admet-155	63	16	and	and	CCONJ
admet-155	63	17	the	the	DET
admet-155	63	18	donor	donor	NOUN
admet-155	63	19	compartment	compartment	NOUN
admet-155	63	20	of	of	ADP
admet-155	63	21	the	the	DET
admet-155	63	22	cell	cell	NOUN
admet-155	63	23	was	be	AUX
admet-155	63	24	covered	cover	VERB
admet-155	63	25	by	by	ADP
admet-155	63	26	parafilm	parafilm	NOUN
admet-155	63	27	®	®	PROPN
admet-155	63	28	.	.	PUNCT
admet-155	64	1	samples	sample	NOUN
admet-155	64	2	(	(	PUNCT
admet-155	64	3	0.5	0.5	NUM
admet-155	64	4	ml	ml	NOUN
admet-155	64	5	)	)	PUNCT
admet-155	64	6	of	of	ADP
admet-155	64	7	the	the	DET
admet-155	64	8	receptor	receptor	NOUN
admet-155	64	9	phase	phase	NOUN
admet-155	64	10	were	be	AUX
admet-155	64	11	withdrawn	withdraw	VERB
admet-155	64	12	at	at	ADP
admet-155	64	13	five	five	NUM
admet-155	64	14	pre	pre	ADJ
admet-155	64	15	-	-	ADJ
admet-155	64	16	determined	determined	ADJ
admet-155	64	17	time	time	NOUN
admet-155	64	18	intervals	interval	NOUN
admet-155	64	19	(	(	PUNCT
admet-155	64	20	30	30	NUM
admet-155	64	21	,	,	PUNCT
admet-155	64	22	60	60	NUM
admet-155	64	23	,	,	PUNCT
admet-155	64	24	90	90	NUM
admet-155	64	25	,	,	PUNCT
admet-155	64	26	120	120	NUM
admet-155	64	27	and	and	CCONJ
admet-155	64	28	180	180	NUM
admet-155	64	29	min	min	NOUN
admet-155	64	30	)	)	PUNCT
admet-155	64	31	,	,	PUNCT
admet-155	64	32	and	and	CCONJ
admet-155	64	33	the	the	DET
admet-155	64	34	cell	cell	NOUN
admet-155	64	35	was	be	AUX
admet-155	64	36	refilled	refill	VERB
admet-155	64	37	with	with	ADP
admet-155	64	38	an	an	DET
admet-155	64	39	equivalent	equivalent	ADJ
admet-155	64	40	amount	amount	NOUN
admet-155	64	41	of	of	ADP
admet-155	64	42	fresh	fresh	ADJ
admet-155	64	43	buffer	buffer	NOUN
admet-155	64	44	solution	solution	NOUN
admet-155	64	45	.	.	PUNCT
admet-155	65	1	a	a	DET
admet-155	65	2	minimum	minimum	NOUN
admet-155	65	3	of	of	ADP
admet-155	65	4	five	five	NUM
admet-155	65	5	determinations	determination	NOUN
admet-155	65	6	was	be	AUX
admet-155	65	7	performed	perform	VERB
admet-155	65	8	using	use	VERB
admet-155	65	9	skin	skin	NOUN
admet-155	65	10	fragments	fragment	NOUN
admet-155	65	11	from	from	ADP
admet-155	65	12	a	a	DET
admet-155	65	13	minimum	minimum	NOUN
admet-155	65	14	of	of	ADP
admet-155	65	15	2	2	NUM
admet-155	65	16	animals	animal	NOUN
admet-155	65	17	for	for	ADP
admet-155	65	18	each	each	DET
admet-155	65	19	compound	compound	NOUN
admet-155	65	20	,	,	PUNCT
admet-155	65	21	and	and	CCONJ
admet-155	65	22	the	the	DET
admet-155	65	23	data	datum	NOUN
admet-155	65	24	was	be	AUX
admet-155	65	25	expressed	express	VERB
admet-155	65	26	as	as	SCONJ
admet-155	65	27	means	mean	VERB
admet-155	65	28	±	±	NUM
admet-155	65	29	sd	sd	NOUN
admet-155	65	30	.	.	PUNCT
admet-155	66	1	the	the	DET
admet-155	66	2	samples	sample	NOUN
admet-155	66	3	were	be	AUX
admet-155	66	4	immediately	immediately	ADV
admet-155	66	5	analysed	analyse	VERB
admet-155	66	6	by	by	ADP
admet-155	66	7	hplc	hplc	PROPN
admet-155	66	8	.	.	PUNCT
admet-155	67	1	the	the	DET
admet-155	67	2	analysis	analysis	NOUN
admet-155	67	3	of	of	ADP
admet-155	67	4	the	the	DET
admet-155	67	5	samples	sample	NOUN
admet-155	67	6	was	be	AUX
admet-155	67	7	performed	perform	VERB
admet-155	67	8	using	use	VERB
admet-155	67	9	an	an	DET
admet-155	67	10	agilent	agilent	PROPN
admet-155	67	11	1200	1200	NUM
admet-155	67	12	series	series	PROPN
admet-155	67	13	hplc	hplc	NOUN
admet-155	67	14	system	system	NOUN
admet-155	67	15	,	,	PUNCT
admet-155	67	16	equipped	equip	VERB
admet-155	67	17	with	with	ADP
admet-155	67	18	a	a	DET
admet-155	67	19	diode	diode	NOUN
admet-155	67	20	array	array	NOUN
admet-155	67	21	detection	detection	NOUN
admet-155	67	22	(	(	PUNCT
admet-155	67	23	dad	dad	NOUN
admet-155	67	24	)	)	PUNCT
admet-155	67	25	system	system	NOUN
admet-155	67	26	,	,	PUNCT
admet-155	67	27	a	a	DET
admet-155	67	28	quaternary	quaternary	ADJ
admet-155	67	29	model	model	NOUN
admet-155	67	30	pump	pump	NOUN
admet-155	67	31	and	and	CCONJ
admet-155	67	32	an	an	DET
admet-155	67	33	automatic	automatic	ADJ
admet-155	67	34	injector	injector	NOUN
admet-155	67	35	(	(	PUNCT
admet-155	67	36	agilent	agilent	PROPN
admet-155	67	37	technologies	technologies	PROPN
admet-155	67	38	,	,	PUNCT
admet-155	67	39	germany	germany	PROPN
admet-155	67	40	)	)	PUNCT
admet-155	67	41	.	.	PUNCT
admet-155	68	1	data	datum	NOUN
admet-155	68	2	acquisition	acquisition	NOUN
admet-155	68	3	was	be	AUX
admet-155	68	4	performed	perform	VERB
admet-155	68	5	using	use	VERB
admet-155	68	6	chemstation	chemstation	NOUN
admet-155	68	7	chromatography	chromatography	NOUN
admet-155	68	8	software	software	NOUN
admet-155	68	9	.	.	PUNCT
admet-155	69	1	a	a	DET
admet-155	69	2	zorbax	zorbax	PROPN
admet-155	69	3	eclipse	eclipse	PROPN
admet-155	69	4	xdb	xdb	X
admet-155	69	5	c18	c18	NOUN
admet-155	69	6	5	5	NUM
admet-155	69	7	μm	μm	NOUN
admet-155	69	8	,	,	PUNCT
admet-155	70	1	4.6×150	4.6×150	PRON
admet-155	70	2	mm	mm	INTJ
admet-155	70	3	(	(	PUNCT
admet-155	70	4	agilent	agilent	PROPN
admet-155	70	5	,	,	PUNCT
admet-155	70	6	usa	usa	PROPN
admet-155	70	7	)	)	PUNCT
admet-155	70	8	chromatographic	chromatographic	ADJ
admet-155	70	9	column	column	NOUN
admet-155	70	10	was	be	AUX
admet-155	70	11	used	use	VERB
admet-155	70	12	.	.	PUNCT
admet-155	71	1	the	the	DET
admet-155	71	2	total	total	ADJ
admet-155	71	3	flow	flow	NOUN
admet-155	71	4	of	of	ADP
admet-155	71	5	the	the	DET
admet-155	71	6	column	column	NOUN
admet-155	71	7	was	be	AUX
admet-155	71	8	0.5	0.5	NUM
admet-155	71	9	ml	ml	NOUN
admet-155	71	10	/	/	SYM
admet-155	71	11	min	min	NOUN
admet-155	71	12	;	;	PUNCT
admet-155	71	13	injection	injection	NOUN
admet-155	71	14	was	be	AUX
admet-155	71	15	10	10	NUM
admet-155	71	16	μl	μl	ADJ
admet-155	71	17	;	;	PUNCT
admet-155	71	18	column	column	NOUN
admet-155	71	19	temperature	temperature	NOUN
admet-155	71	20	was	be	AUX
admet-155	71	21	30	30	NUM
admet-155	71	22	°	°	NOUN
admet-155	71	23	c	c	NOUN
admet-155	71	24	;	;	PUNCT
admet-155	71	25	and	and	CCONJ
admet-155	71	26	sample	sample	NOUN
admet-155	71	27	temperature	temperature	NOUN
admet-155	71	28	was	be	AUX
admet-155	71	29	10	10	NUM
admet-155	71	30	°	°	NOUN
admet-155	71	31	c	c	NOUN
admet-155	71	32	.	.	PUNCT
admet-155	72	1	the	the	DET
admet-155	72	2	detection	detection	NOUN
admet-155	72	3	wavelength	wavelength	NOUN
admet-155	72	4	of	of	ADP
admet-155	72	5	254	254	NUM
admet-155	72	6	nm	nm	NOUN
admet-155	72	7	was	be	AUX
admet-155	72	8	chosen	choose	VERB
admet-155	72	9	;	;	PUNCT
admet-155	72	10	the	the	DET
admet-155	72	11	time	time	NOUN
admet-155	72	12	of	of	ADP
admet-155	72	13	analysis	analysis	NOUN
admet-155	72	14	was	be	AUX
admet-155	72	15	10	10	NUM
admet-155	72	16	min	min	NOUN
admet-155	72	17	.	.	PUNCT
admet-155	73	1	a	a	DET
admet-155	73	2	mixture	mixture	NOUN
admet-155	73	3	of	of	ADP
admet-155	73	4	meoh	meoh	PROPN
admet-155	73	5	(	(	PUNCT
admet-155	73	6	hplc	hplc	NOUN
admet-155	73	7	grade	grade	NOUN
admet-155	73	8	,	,	PUNCT
admet-155	73	9	85.0	85.0	NUM
admet-155	73	10	%	%	NOUN
admet-155	73	11	)	)	PUNCT
admet-155	73	12	and	and	CCONJ
admet-155	73	13	h2o	h2o	PROPN
admet-155	73	14	(	(	PUNCT
admet-155	73	15	hplc	hplc	NOUN
admet-155	73	16	–	–	PUNCT
admet-155	73	17	mili	mili	NOUN
admet-155	73	18	-	-	PUNCT
admet-155	73	19	q	q	NOUN
admet-155	73	20	grade	grade	NOUN
admet-155	73	21	,	,	PUNCT
admet-155	73	22	15.0	15.0	NUM
admet-155	73	23	%	%	NOUN
admet-155	73	24	)	)	PUNCT
admet-155	73	25	was	be	AUX
admet-155	73	26	used	use	VERB
admet-155	73	27	as	as	ADP
admet-155	73	28	a	a	DET
admet-155	73	29	mobile	mobile	ADJ
admet-155	73	30	phase	phase	NOUN
admet-155	73	31	.	.	PUNCT
admet-155	74	1	the	the	DET
admet-155	74	2	retention	retention	NOUN
admet-155	74	3	time	time	NOUN
admet-155	74	4	(	(	PUNCT
admet-155	74	5	tr	tr	VERB
admet-155	74	6	)	)	PUNCT
admet-155	74	7	of	of	ADP
admet-155	74	8	rutin	rutin	NOUN
admet-155	74	9	was	be	AUX
admet-155	74	10	3.70±0.05	3.70±0.05	NOUN
admet-155	74	11	min	min	NOUN
admet-155	74	12	;	;	PUNCT
admet-155	74	13	the	the	DET
admet-155	74	14	limit	limit	NOUN
admet-155	74	15	of	of	ADP
admet-155	74	16	detection	detection	NOUN
admet-155	74	17	(	(	PUNCT
admet-155	74	18	lod	lod	PROPN
admet-155	74	19	)	)	PUNCT
admet-155	74	20	was	be	AUX
admet-155	74	21	0.99	0.99	NUM
admet-155	74	22	ng	ng	NOUN
admet-155	74	23	/	/	SYM
admet-155	74	24	ml	ml	PROPN
admet-155	74	25	;	;	PUNCT
admet-155	74	26	and	and	CCONJ
admet-155	74	27	the	the	DET
admet-155	74	28	limit	limit	NOUN
admet-155	74	29	of	of	ADP
admet-155	74	30	quantification	quantification	NOUN
admet-155	74	31	(	(	PUNCT
admet-155	74	32	loq	loq	PROPN
admet-155	74	33	)	)	PUNCT
admet-155	74	34	was	be	AUX
admet-155	74	35	3.3	3.3	NUM
admet-155	74	36	ng	ng	NOUN
admet-155	74	37	/	/	SYM
admet-155	74	38	ml	ml	PROPN
admet-155	74	39	.	.	NOUN
admet-155	75	1	results	result	NOUN
admet-155	75	2	and	and	CCONJ
admet-155	75	3	discussion	discussion	NOUN
admet-155	75	4	rutin	rutin	NOUN
admet-155	75	5	was	be	AUX
admet-155	75	6	chosen	choose	VERB
admet-155	75	7	as	as	ADP
admet-155	75	8	a	a	DET
admet-155	75	9	frequently	frequently	ADV
admet-155	75	10	applied	apply	VERB
admet-155	75	11	venopharmaceutical	venopharmaceutical	ADJ
admet-155	75	12	for	for	ADP
admet-155	75	13	the	the	DET
admet-155	75	14	topical	topical	ADJ
admet-155	75	15	treatment	treatment	NOUN
admet-155	75	16	of	of	ADP
admet-155	75	17	the	the	DET
admet-155	75	18	fragility	fragility	NOUN
admet-155	75	19	of	of	ADP
admet-155	75	20	vascular	vascular	ADJ
admet-155	75	21	wall	wall	NOUN
admet-155	75	22	that	that	PRON
admet-155	75	23	can	can	AUX
admet-155	75	24	be	be	AUX
admet-155	75	25	associated	associate	VERB
admet-155	75	26	with	with	ADP
admet-155	75	27	various	various	ADJ
admet-155	75	28	injuries	injury	NOUN
admet-155	75	29	of	of	ADP
admet-155	75	30	the	the	DET
admet-155	75	31	skin	skin	NOUN
admet-155	75	32	,	,	PUNCT
admet-155	75	33	because	because	SCONJ
admet-155	75	34	alaptide	alaptide	ADJ
admet-155	75	35	itself	itself	PRON
admet-155	75	36	shows	show	VERB
admet-155	75	37	significant	significant	ADJ
admet-155	75	38	curative	curative	ADJ
admet-155	75	39	effect	effect	NOUN
admet-155	75	40	on	on	ADP
admet-155	75	41	the	the	DET
admet-155	75	42	skin	skin	NOUN
admet-155	75	43	[	[	X
admet-155	75	44	8,31	8,31	NUM
admet-155	75	45	]	]	PUNCT
admet-155	75	46	.	.	PUNCT
admet-155	76	1	the	the	DET
admet-155	76	2	rapid	rapid	ADJ
admet-155	76	3	in	in	ADP
admet-155	76	4	vitro	vitro	X
admet-155	76	5	skin	skin	NOUN
admet-155	76	6	permeation	permeation	NOUN
admet-155	76	7	screening	screen	VERB
admet-155	76	8	experiments	experiment	NOUN
admet-155	76	9	were	be	AUX
admet-155	76	10	performed	perform	VERB
admet-155	76	11	using	use	VERB
admet-155	76	12	static	static	ADJ
admet-155	76	13	franz	franz	NOUN
admet-155	76	14	diffusion	diffusion	NOUN
admet-155	76	15	cells	cell	NOUN
admet-155	76	16	[	[	X
admet-155	76	17	32	32	NUM
admet-155	76	18	]	]	PUNCT
admet-155	76	19	within	within	ADP
admet-155	76	20	3	3	NUM
admet-155	76	21	hours	hour	NOUN
admet-155	76	22	only	only	ADV
admet-155	76	23	.	.	PUNCT
admet-155	77	1	full	full	ADJ
admet-155	77	2	-	-	PUNCT
admet-155	77	3	thickness	thickness	NOUN
admet-155	77	4	pig	pig	NOUN
admet-155	77	5	ear	ear	NOUN
admet-155	77	6	skin	skin	NOUN
admet-155	77	7	was	be	AUX
admet-155	77	8	selected	select	VERB
admet-155	77	9	for	for	ADP
admet-155	77	10	in	in	ADP
admet-155	77	11	vitro	vitro	X
admet-155	77	12	evaluation	evaluation	NOUN
admet-155	77	13	of	of	ADP
admet-155	77	14	permeation	permeation	NOUN
admet-155	77	15	.	.	PUNCT
admet-155	78	1	this	this	DET
admet-155	78	2	tissue	tissue	NOUN
admet-155	78	3	is	be	AUX
admet-155	78	4	a	a	DET
admet-155	78	5	suitable	suitable	ADJ
admet-155	78	6	in	in	ADP
admet-155	78	7	vitro	vitro	X
admet-155	78	8	model	model	NOUN
admet-155	78	9	of	of	ADP
admet-155	78	10	human	human	ADJ
admet-155	78	11	skin	skin	NOUN
admet-155	78	12	[	[	X
admet-155	78	13	33	33	NUM
admet-155	78	14	]	]	PUNCT
admet-155	78	15	,	,	PUNCT
admet-155	78	16	because	because	SCONJ
admet-155	78	17	porcine	porcine	NOUN
admet-155	78	18	skin	skin	NOUN
admet-155	78	19	has	have	AUX
admet-155	78	20	shown	show	VERB
admet-155	78	21	to	to	PART
admet-155	78	22	be	be	AUX
admet-155	78	23	histologically	histologically	ADV
admet-155	78	24	and	and	CCONJ
admet-155	78	25	biochemically	biochemically	ADV
admet-155	78	26	similar	similar	ADJ
admet-155	78	27	to	to	ADP
admet-155	78	28	human	human	ADJ
admet-155	78	29	skin	skin	NOUN
admet-155	78	30	,	,	PUNCT
admet-155	78	31	and	and	CCONJ
admet-155	78	32	it	it	PRON
admet-155	78	33	has	have	AUX
admet-155	78	34	been	be	AUX
admet-155	78	35	used	use	VERB
admet-155	78	36	in	in	ADP
admet-155	78	37	numerous	numerous	ADJ
admet-155	78	38	studies	study	NOUN
admet-155	78	39	[	[	X
admet-155	78	40	4	4	NUM
admet-155	78	41	]	]	PUNCT
admet-155	78	42	.	.	PUNCT
admet-155	79	1	the	the	DET
admet-155	79	2	permeation	permeation	NOUN
admet-155	79	3	of	of	ADP
admet-155	79	4	rutin	rutin	NOUN
admet-155	79	5	through	through	ADP
admet-155	79	6	full	full	ADJ
admet-155	79	7	-	-	PUNCT
admet-155	79	8	thickness	thickness	NOUN
admet-155	79	9	pig	pig	NOUN
admet-155	79	10	ear	ear	VERB
admet-155	79	11	skin	skin	NOUN
admet-155	79	12	without	without	ADP
admet-155	79	13	and	and	CCONJ
admet-155	79	14	with	with	ADP
admet-155	79	15	1	1	NUM
admet-155	79	16	%	%	NOUN
admet-155	79	17	admet	admet	NOUN
admet-155	79	18	&	&	CCONJ
admet-155	79	19	dmpk	dmpk	PROPN
admet-155	79	20	2(4	2(4	NUM
admet-155	79	21	)	)	PUNCT
admet-155	79	22	(	(	PUNCT
admet-155	79	23	2014	2014	NUM
admet-155	79	24	)	)	PUNCT
admet-155	79	25	248	248	NUM
admet-155	79	26	-	-	SYM
admet-155	79	27	253	253	NUM
admet-155	79	28	rutin	rutin	NOUN
admet-155	79	29	permeation	permeation	NOUN
admet-155	79	30	enhancement	enhancement	NOUN
admet-155	79	31	by	by	ADP
admet-155	79	32	alaptide	alaptide	ADJ
admet-155	79	33	enantiomers	enantiomer	NOUN
admet-155	79	34	doi	doi	NOUN
admet-155	79	35	:	:	PUNCT
admet-155	79	36	10.5599	10.5599	NUM
admet-155	79	37	/	/	SYM
admet-155	79	38	admet.2.4.155	admet.2.4.155	PROPN
admet-155	79	39	251	251	NUM
admet-155	79	40	(	(	PUNCT
admet-155	79	41	w	w	NOUN
admet-155	79	42	/	/	SYM
admet-155	79	43	w	w	NOUN
admet-155	79	44	related	relate	VERB
admet-155	79	45	to	to	ADP
admet-155	79	46	rutin	rutin	NOUN
admet-155	79	47	)	)	PUNCT
admet-155	79	48	(	(	PUNCT
admet-155	79	49	s)or	s)or	NOUN
admet-155	79	50	(	(	PUNCT
admet-155	79	51	r)-enantiomer	r)-enantiomer	NOUN
admet-155	79	52	of	of	ADP
admet-155	79	53	alaptide	alaptide	NOUN
admet-155	79	54	was	be	AUX
admet-155	79	55	tested	test	VERB
admet-155	79	56	from	from	ADP
admet-155	79	57	carboxymethyl	carboxymethyl	NOUN
admet-155	79	58	cellulose	cellulose	NOUN
admet-155	79	59	gel	gel	NOUN
admet-155	79	60	as	as	ADP
admet-155	79	61	a	a	DET
admet-155	79	62	donor	donor	NOUN
admet-155	79	63	vehicle	vehicle	NOUN
admet-155	79	64	.	.	PUNCT
admet-155	80	1	all	all	DET
admet-155	80	2	the	the	DET
admet-155	80	3	results	result	NOUN
admet-155	80	4	are	be	AUX
admet-155	80	5	provided	provide	VERB
admet-155	80	6	in	in	ADP
admet-155	80	7	table	table	NOUN
admet-155	80	8	1	1	NUM
admet-155	80	9	and	and	CCONJ
admet-155	80	10	illustrated	illustrate	VERB
admet-155	80	11	in	in	ADP
admet-155	80	12	figure	figure	NOUN
admet-155	80	13	2	2	NUM
admet-155	80	14	.	.	PUNCT
admet-155	80	15	table	table	NOUN
admet-155	80	16	1	1	NUM
admet-155	80	17	.	.	PUNCT
admet-155	80	18	cumulative	cumulative	ADJ
admet-155	80	19	permeated	permeate	VERB
admet-155	80	20	amounts	amount	NOUN
admet-155	80	21	qt	qt	NOUN
admet-155	80	22	per	per	ADP
admet-155	80	23	unit	unit	NOUN
admet-155	80	24	area	area	NOUN
admet-155	80	25	[	[	X
admet-155	80	26	μg	μg	PROPN
admet-155	80	27	/	/	SYM
admet-155	80	28	cm	cm	PROPN
admet-155	80	29	2	2	NUM
admet-155	80	30	]	]	PUNCT
admet-155	80	31	of	of	ADP
admet-155	80	32	rutin	rutin	NOUN
admet-155	80	33	from	from	ADP
admet-155	80	34	carboxymethyl	carboxymethyl	NOUN
admet-155	80	35	cellulose	cellulose	NOUN
admet-155	80	36	gel	gel	NOUN
admet-155	80	37	without	without	ADP
admet-155	80	38	and	and	CCONJ
admet-155	80	39	with	with	ADP
admet-155	80	40	(	(	PUNCT
admet-155	80	41	s)-alaptide	s)-alaptide	PUNCT
admet-155	80	42	or	or	CCONJ
admet-155	80	43	(	(	PUNCT
admet-155	80	44	r)-alaptide	r)-alaptide	PUNCT
admet-155	80	45	as	as	ADP
admet-155	80	46	modifiers	modifier	NOUN
admet-155	80	47	of	of	ADP
admet-155	80	48	transdermal	transdermal	ADJ
admet-155	80	49	permeation	permeation	NOUN
admet-155	80	50	achieved	achieve	VERB
admet-155	80	51	in	in	ADP
admet-155	80	52	in	in	ADP
admet-155	80	53	vitro	vitro	X
admet-155	80	54	transdermal	transdermal	ADJ
admet-155	80	55	permeation	permeation	NOUN
admet-155	80	56	experiments	experiment	NOUN
admet-155	80	57	using	use	VERB
admet-155	80	58	franz	franz	NOUN
admet-155	80	59	diffusion	diffusion	NOUN
admet-155	80	60	cell	cell	NOUN
admet-155	80	61	.	.	PUNCT
admet-155	81	1	qt	qt	NOUN
admet-155	81	2	are	be	AUX
admet-155	81	3	expressed	express	VERB
admet-155	81	4	as	as	ADP
admet-155	81	5	mean	mean	NOUN
admet-155	81	6	±	±	NUM
admet-155	81	7	sd	sd	NOUN
admet-155	81	8	(	(	PUNCT
admet-155	81	9	n	n	NOUN
admet-155	81	10	=	=	SYM
admet-155	81	11	5	5	NUM
admet-155	81	12	experiments	experiment	NOUN
admet-155	81	13	)	)	PUNCT
admet-155	81	14	.	.	PUNCT
admet-155	82	1	time	time	NOUN
admet-155	83	1	[	[	X
admet-155	83	2	h	h	X
admet-155	83	3	]	]	X
admet-155	83	4	cumulative	cumulative	ADJ
admet-155	83	5	permeated	permeate	VERB
admet-155	83	6	amounts	amount	NOUN
admet-155	83	7	qt	qt	NOUN
admet-155	83	8	per	per	ADP
admet-155	83	9	unit	unit	NOUN
admet-155	83	10	area[µg	area[µg	PROPN
admet-155	83	11	/	/	SYM
admet-155	83	12	cm2	cm2	PROPN
admet-155	83	13	]	]	PUNCT
admet-155	83	14	rutin	rutin	NOUN
admet-155	83	15	rutin+(s)-alaptide	rutin+(s)-alaptide	NOUN
admet-155	83	16	rutin+(r)-alaptide	rutin+(r)-alaptide	NOUN
admet-155	83	17	0.5	0.5	NUM
admet-155	83	18	3.7±0.6	3.7±0.6	NUM
admet-155	83	19	5.5±0.7	5.5±0.7	NUM
admet-155	83	20	4.6±0.6	4.6±0.6	NUM
admet-155	83	21	1.0	1.0	NUM
admet-155	83	22	6.5±0.7	6.5±0.7	NUM
admet-155	83	23	9.7±0.9	9.7±0.9	NUM
admet-155	83	24	7.7±0.8	7.7±0.8	NUM
admet-155	83	25	1.5	1.5	NUM
admet-155	83	26	9.0±0.5	9.0±0.5	NUM
admet-155	83	27	15.4±1.0	15.4±1.0	NUM
admet-155	83	28	11.9±1.0	11.9±1.0	NUM
admet-155	83	29	2.0	2.0	NUM
admet-155	83	30	13.2±1.1	13.2±1.1	NUM
admet-155	83	31	19.4±1.2	19.4±1.2	NUM
admet-155	83	32	15.1±0.8	15.1±0.8	NUM
admet-155	83	33	3.0	3.0	NUM
admet-155	83	34	16.7±1.3	16.7±1.3	NUM
admet-155	83	35	25.9±1.5	25.9±1.5	NUM
admet-155	83	36	20.0±1.1	20.0±1.1	NUM
admet-155	83	37	0	0	NUM
admet-155	83	38	5	5	NUM
admet-155	83	39	10	10	NUM
admet-155	83	40	15	15	NUM
admet-155	83	41	20	20	NUM
admet-155	83	42	25	25	NUM
admet-155	83	43	30	30	NUM
admet-155	83	44	0.5	0.5	NUM
admet-155	83	45	1	1	NUM
admet-155	83	46	1.5	1.5	NUM
admet-155	83	47	2	2	NUM
admet-155	83	48	3	3	NUM
admet-155	83	49	q	q	NOUN
admet-155	83	50	t	t	NOUN
admet-155	83	51	[	[	X
admet-155	83	52			NOUN
admet-155	83	53	g	g	NOUN
admet-155	83	54	/c	/c	PUNCT
admet-155	83	55	m	m	VERB
admet-155	83	56	2	2	NUM
admet-155	83	57	]	]	PUNCT
admet-155	83	58	time	time	NOUN
admet-155	84	1	[	[	X
admet-155	84	2	h	h	X
admet-155	84	3	]	]	X
admet-155	84	4	rut	rut	NOUN
admet-155	84	5	rut+sala	rut+sala	NOUN
admet-155	84	6	rut+rala	rut+rala	NOUN
admet-155	84	7	figure	figure	NOUN
admet-155	84	8	2	2	NUM
admet-155	84	9	.	.	PUNCT
admet-155	85	1	in	in	ADP
admet-155	85	2	vitro	vitro	X
admet-155	85	3	profile	profile	NOUN
admet-155	85	4	of	of	ADP
admet-155	85	5	cumulative	cumulative	ADJ
admet-155	85	6	permeated	permeate	VERB
admet-155	85	7	amounts	amount	NOUN
admet-155	85	8	qt	qt	NOUN
admet-155	85	9	per	per	ADP
admet-155	85	10	unit	unit	NOUN
admet-155	85	11	area	area	NOUN
admet-155	86	1	[	[	X
admet-155	86	2	μg	μg	PROPN
admet-155	86	3	/	/	SYM
admet-155	86	4	cm	cm	PROPN
admet-155	86	5	2	2	NUM
admet-155	86	6	]	]	PUNCT
admet-155	86	7	in	in	ADP
admet-155	86	8	time	time	NOUN
admet-155	86	9	of	of	ADP
admet-155	86	10	rutin	rutin	NOUN
admet-155	86	11	(	(	PUNCT
admet-155	86	12	rut	rut	NOUN
admet-155	86	13	)	)	PUNCT
admet-155	86	14	alone	alone	ADV
admet-155	86	15	and	and	CCONJ
admet-155	86	16	after	after	ADP
admet-155	86	17	addition	addition	NOUN
admet-155	86	18	of	of	ADP
admet-155	86	19	1	1	NUM
admet-155	86	20	%	%	NOUN
admet-155	86	21	w	w	PROPN
admet-155	86	22	/	/	SYM
admet-155	86	23	w	w	NOUN
admet-155	86	24	of	of	ADP
admet-155	86	25	(	(	PUNCT
admet-155	86	26	s)-alaptide	s)-alaptide	PUNCT
admet-155	86	27	(	(	PUNCT
admet-155	86	28	sala	sala	PROPN
admet-155	86	29	)	)	PUNCT
admet-155	86	30	or	or	CCONJ
admet-155	86	31	(	(	PUNCT
admet-155	86	32	r)-alaptide	r)-alaptide	X
admet-155	86	33	(	(	PUNCT
admet-155	86	34	rala	rala	NOUN
admet-155	86	35	)	)	PUNCT
admet-155	86	36	from	from	ADP
admet-155	86	37	carboxymethyl	carboxymethyl	NOUN
admet-155	86	38	cellulose	cellulose	NOUN
admet-155	86	39	gel	gel	NOUN
admet-155	86	40	through	through	ADP
admet-155	86	41	skin	skin	NOUN
admet-155	86	42	.	.	PUNCT
admet-155	87	1	qt	qt	NOUN
admet-155	87	2	values	value	NOUN
admet-155	87	3	are	be	AUX
admet-155	87	4	expressed	express	VERB
admet-155	87	5	as	as	ADP
admet-155	87	6	mean	mean	NOUN
admet-155	87	7	±	±	NUM
admet-155	87	8	sd	sd	NOUN
admet-155	87	9	(	(	PUNCT
admet-155	87	10	n	n	NOUN
admet-155	87	11	=	=	SYM
admet-155	87	12	5	5	NUM
admet-155	87	13	experiments	experiment	NOUN
admet-155	87	14	)	)	PUNCT
admet-155	87	15	.	.	PUNCT
admet-155	88	1	as	as	SCONJ
admet-155	88	2	the	the	DET
admet-155	88	3	presented	present	VERB
admet-155	88	4	study	study	NOUN
admet-155	88	5	represents	represent	VERB
admet-155	88	6	a	a	DET
admet-155	88	7	preliminary	preliminary	ADJ
admet-155	88	8	rapid	rapid	NOUN
admet-155	88	9	in	in	ADP
admet-155	88	10	vitro	vitro	X
admet-155	88	11	screening	screen	VERB
admet-155	88	12	,	,	PUNCT
admet-155	88	13	all	all	DET
admet-155	88	14	the	the	DET
admet-155	88	15	experiments	experiment	NOUN
admet-155	88	16	were	be	AUX
admet-155	88	17	performed	perform	VERB
admet-155	88	18	only	only	ADV
admet-155	88	19	in	in	ADP
admet-155	88	20	the	the	DET
admet-155	88	21	time	time	NOUN
admet-155	88	22	range	range	NOUN
admet-155	88	23	from	from	ADP
admet-155	88	24	0.5	0.5	NUM
admet-155	88	25	to	to	ADP
admet-155	88	26	3.0	3.0	NUM
admet-155	88	27	h.	h.	NOUN
admet-155	88	28	the	the	DET
admet-155	88	29	values	value	NOUN
admet-155	88	30	obtained	obtain	VERB
admet-155	88	31	from	from	ADP
admet-155	88	32	the	the	DET
admet-155	88	33	permeation	permeation	NOUN
admet-155	88	34	experiments	experiment	NOUN
admet-155	88	35	were	be	AUX
admet-155	88	36	expressed	express	VERB
admet-155	88	37	as	as	ADP
admet-155	88	38	the	the	DET
admet-155	88	39	cumulative	cumulative	ADJ
admet-155	88	40	permeated	permeate	VERB
admet-155	88	41	amount	amount	NOUN
admet-155	88	42	of	of	ADP
admet-155	88	43	the	the	DET
admet-155	88	44	drug	drug	NOUN
admet-155	88	45	(	(	PUNCT
admet-155	88	46	qt	qt	X
admet-155	88	47	[	[	X
admet-155	88	48	μg	μg	X
admet-155	88	49	]	]	PUNCT
admet-155	88	50	)	)	PUNCT
admet-155	88	51	per	per	ADP
admet-155	88	52	unit	unit	NOUN
admet-155	88	53	of	of	ADP
admet-155	88	54	skin	skin	NOUN
admet-155	88	55	surface	surface	NOUN
admet-155	88	56	area	area	NOUN
admet-155	88	57	(	(	PUNCT
admet-155	88	58	0.6359	0.6359	NUM
admet-155	88	59	cm2	cm2	NOUN
admet-155	88	60	)	)	PUNCT
admet-155	88	61	,	,	PUNCT
admet-155	88	62	see	see	VERB
admet-155	88	63	table	table	NOUN
admet-155	88	64	1	1	NUM
admet-155	88	65	.	.	PUNCT
admet-155	89	1	due	due	ADP
admet-155	89	2	to	to	ADP
admet-155	89	3	the	the	DET
admet-155	89	4	short	short	ADJ
admet-155	89	5	time	time	NOUN
admet-155	89	6	interval	interval	NOUN
admet-155	89	7	of	of	ADP
admet-155	89	8	experiments	experiment	NOUN
admet-155	89	9	steady	steady	ADJ
admet-155	89	10	-	-	PUNCT
admet-155	89	11	state	state	NOUN
admet-155	89	12	permeation	permeation	NOUN
admet-155	89	13	flux	flux	NOUN
admet-155	89	14	and	and	CCONJ
admet-155	89	15	lag	lag	NOUN
admet-155	89	16	time	time	NOUN
admet-155	89	17	can	can	AUX
admet-155	89	18	not	not	PART
admet-155	89	19	be	be	AUX
admet-155	89	20	calculated	calculate	VERB
admet-155	89	21	,	,	PUNCT
admet-155	89	22	but	but	CCONJ
admet-155	89	23	this	this	PRON
admet-155	89	24	was	be	AUX
admet-155	89	25	not	not	PART
admet-155	89	26	the	the	DET
admet-155	89	27	aim	aim	NOUN
admet-155	89	28	of	of	ADP
admet-155	89	29	the	the	DET
admet-155	89	30	experiments	experiment	NOUN
admet-155	89	31	.	.	PUNCT
admet-155	90	1	the	the	DET
admet-155	90	2	dependences	dependence	NOUN
admet-155	90	3	of	of	ADP
admet-155	90	4	the	the	DET
admet-155	90	5	cumulative	cumulative	ADJ
admet-155	90	6	permeated	permeate	VERB
admet-155	90	7	amount	amount	NOUN
admet-155	90	8	of	of	ADP
admet-155	90	9	the	the	DET
admet-155	90	10	drug	drug	NOUN
admet-155	90	11	per	per	ADP
admet-155	90	12	unit	unit	NOUN
admet-155	90	13	of	of	ADP
admet-155	90	14	skin	skin	NOUN
admet-155	90	15	surface	surface	NOUN
admet-155	90	16	area	area	NOUN
admet-155	90	17	in	in	ADP
admet-155	90	18	time	time	NOUN
admet-155	90	19	(	(	PUNCT
admet-155	90	20	qt	qt	NOUN
admet-155	90	21	versus	versus	ADP
admet-155	90	22	t	t	PROPN
admet-155	90	23	)	)	PUNCT
admet-155	90	24	are	be	AUX
admet-155	90	25	shown	show	VERB
admet-155	90	26	in	in	ADP
admet-155	90	27	figure	figure	NOUN
admet-155	90	28	2	2	NUM
admet-155	90	29	.	.	PUNCT
admet-155	90	30	based	base	VERB
admet-155	90	31	on	on	ADP
admet-155	90	32	the	the	DET
admet-155	90	33	results	result	NOUN
admet-155	90	34	it	it	PRON
admet-155	90	35	can	can	AUX
admet-155	90	36	be	be	AUX
admet-155	90	37	stated	state	VERB
admet-155	90	38	that	that	SCONJ
admet-155	90	39	permeation	permeation	NOUN
admet-155	90	40	of	of	ADP
admet-155	90	41	rutin	rutin	NOUN
admet-155	90	42	through	through	ADP
admet-155	90	43	the	the	DET
admet-155	90	44	skin	skin	NOUN
admet-155	90	45	increased	increase	VERB
admet-155	90	46	linearly	linearly	ADV
admet-155	90	47	with	with	ADP
admet-155	90	48	time	time	NOUN
admet-155	90	49	;	;	PUNCT
admet-155	90	50	for	for	SCONJ
admet-155	90	51	rutin	rutin	NOUN
admet-155	90	52	alone	alone	ADJ
admet-155	90	53	correlation	correlation	NOUN
admet-155	90	54	coefficient	coefficient	NOUN
admet-155	90	55	was	be	AUX
admet-155	90	56	r	r	NOUN
admet-155	90	57	=	=	SYM
admet-155	90	58	0.9891	0.9891	NUM
admet-155	90	59	and	and	CCONJ
admet-155	90	60	slope	slope	VERB
admet-155	90	61	5.95	5.95	NUM
admet-155	90	62	/cm2	/cm2	NOUN
admet-155	90	63	/	/	SYM
admet-155	90	64	h	h	NOUN
admet-155	90	65	;	;	PUNCT
admet-155	90	66	for	for	ADP
admet-155	90	67	rutin	rutin	NOUN
admet-155	90	68	with	with	ADP
admet-155	90	69	(	(	PUNCT
admet-155	90	70	r)-alaptide	r)-alaptide	NOUN
admet-155	90	71	r	r	NOUN
admet-155	90	72	=	=	SYM
admet-155	90	73	0.9896	0.9896	NUM
admet-155	90	74	and	and	CCONJ
admet-155	90	75	slope	slope	VERB
admet-155	90	76	7.16	7.16	NUM
admet-155	90	77	/cm2	/cm2	NOUN
admet-155	90	78	/	/	SYM
admet-155	90	79	h	h	NOUN
admet-155	90	80	;	;	PUNCT
admet-155	90	81	and	and	CCONJ
admet-155	90	82	for	for	ADP
admet-155	90	83	rutin	rutin	NOUN
admet-155	90	84	with	with	ADP
admet-155	90	85	(	(	PUNCT
admet-155	90	86	s)-alaptide	s)-alaptide	PUNCT
admet-155	90	87	r	r	NOUN
admet-155	90	88	=	=	SYM
admet-155	90	89	0.9915	0.9915	NUM
admet-155	90	90	and	and	CCONJ
admet-155	90	91	slope	slope	VERB
admet-155	90	92	9.21	9.21	NUM
admet-155	90	93	/cm2	/cm2	NOUN
admet-155	90	94	/	/	SYM
admet-155	90	95	h.	h.	NOUN
admet-155	90	96	based	base	VERB
admet-155	90	97	on	on	ADP
admet-155	90	98	the	the	DET
admet-155	90	99	ratios	ratio	NOUN
admet-155	90	100	slopes	slope	NOUN
admet-155	90	101	of	of	ADP
admet-155	90	102	the	the	DET
admet-155	90	103	linear	linear	ADJ
admet-155	90	104	dependences	dependence	NOUN
admet-155	90	105	qt	qt	VERB
admet-155	90	106	versus	versus	ADP
admet-155	90	107	t	t	PROPN
admet-155	90	108	permeation	permeation	NOUN
admet-155	90	109	enhancement	enhancement	NOUN
admet-155	90	110	within	within	ADP
admet-155	90	111	the	the	DET
admet-155	90	112	studied	study	VERB
admet-155	90	113	time	time	NOUN
admet-155	90	114	span	span	NOUN
admet-155	90	115	(	(	PUNCT
admet-155	90	116	up	up	ADP
admet-155	90	117	to	to	PART
admet-155	90	118	3	3	NUM
admet-155	90	119	h	h	NOUN
admet-155	90	120	)	)	PUNCT
admet-155	90	121	can	can	AUX
admet-155	90	122	be	be	AUX
admet-155	90	123	evaluated	evaluate	VERB
admet-155	90	124	.	.	PUNCT
admet-155	91	1	the	the	DET
admet-155	91	2	permeation	permeation	NOUN
admet-155	91	3	of	of	ADP
admet-155	91	4	rutin	rutin	NOUN
admet-155	91	5	with	with	ADP
admet-155	91	6	(	(	PUNCT
admet-155	91	7	r)-alaptide	r)-alaptide	NUM
admet-155	91	8	was	be	AUX
admet-155	91	9	1.22	1.22	NUM
admet-155	91	10	-	-	ADJ
admet-155	91	11	fold	fold	VERB
admet-155	91	12	higher	high	ADJ
admet-155	91	13	than	than	ADP
admet-155	91	14	without	without	ADP
admet-155	91	15	the	the	DET
admet-155	91	16	addition	addition	NOUN
admet-155	91	17	of	of	ADP
admet-155	91	18	(	(	PUNCT
admet-155	91	19	r)-alaptide	r)-alaptide	NOUN
admet-155	91	20	.	.	PUNCT
admet-155	92	1	the	the	DET
admet-155	92	2	addition	addition	NOUN
admet-155	92	3	of	of	ADP
admet-155	92	4	(	(	PUNCT
admet-155	92	5	s)-alaptide	s)-alaptide	PUNCT
admet-155	92	6	to	to	PART
admet-155	92	7	carboxymethyl	carboxymethyl	PROPN
admet-155	92	8	cellulose	cellulose	NOUN
admet-155	92	9	gel	gel	NOUN
admet-155	92	10	caused	cause	VERB
admet-155	92	11	1.54	1.54	NUM
admet-155	92	12	-	-	PUNCT
admet-155	92	13	fold	fold	ADJ
admet-155	92	14	higher	high	ADJ
admet-155	92	15	permeation	permeation	NOUN
admet-155	92	16	of	of	ADP
admet-155	92	17	rutin	rutin	NOUN
admet-155	92	18	through	through	ADP
admet-155	92	19	the	the	DET
admet-155	92	20	skin	skin	NOUN
admet-155	92	21	than	than	ADP
admet-155	92	22	from	from	ADP
admet-155	92	23	the	the	DET
admet-155	92	24	jampilek	jampilek	NOUN
admet-155	92	25	et	et	PROPN
admet-155	92	26	al	al	PROPN
admet-155	92	27	.	.	PROPN
admet-155	92	28	admet	admet	PROPN
admet-155	92	29	&	&	CCONJ
admet-155	92	30	dmpk	dmpk	PROPN
admet-155	92	31	2(4	2(4	NUM
admet-155	92	32	)	)	PUNCT
admet-155	92	33	(	(	PUNCT
admet-155	92	34	2014	2014	NUM
admet-155	92	35	)	)	PUNCT
admet-155	92	36	248	248	NUM
admet-155	92	37	-	-	SYM
admet-155	92	38	253	253	NUM
admet-155	92	39	252	252	NUM
admet-155	92	40	formulation	formulation	NOUN
admet-155	92	41	without	without	ADP
admet-155	92	42	(	(	PUNCT
admet-155	92	43	s)-alaptide	s)-alaptide	NOUN
admet-155	92	44	.	.	PUNCT
admet-155	93	1	on	on	ADP
admet-155	93	2	the	the	DET
admet-155	93	3	other	other	ADJ
admet-155	93	4	hand	hand	NOUN
admet-155	93	5	,	,	PUNCT
admet-155	93	6	rutin	rutin	NOUN
admet-155	93	7	permeated	permeate	VERB
admet-155	93	8	from	from	ADP
admet-155	93	9	the	the	DET
admet-155	93	10	formulation	formulation	NOUN
admet-155	93	11	containing	contain	VERB
admet-155	93	12	(	(	PUNCT
admet-155	93	13	s)-alaptide	s)-alaptide	PUNCT
admet-155	93	14	only	only	ADV
admet-155	93	15	1.27	1.27	NUM
admet-155	93	16	-	-	NUM
admet-155	93	17	fold	fold	VERB
admet-155	93	18	more	more	ADV
admet-155	93	19	compared	compare	VERB
admet-155	93	20	with	with	ADP
admet-155	93	21	(	(	PUNCT
admet-155	93	22	r)-alaptide	r)-alaptide	NOUN
admet-155	93	23	.	.	PUNCT
admet-155	94	1	as	as	SCONJ
admet-155	94	2	mentioned	mention	VERB
admet-155	94	3	above	above	ADP
admet-155	94	4	the	the	DET
admet-155	94	5	components	component	NOUN
admet-155	94	6	of	of	ADP
admet-155	94	7	stratum	stratum	NOUN
admet-155	94	8	corneum	corneum	NOUN
admet-155	94	9	form	form	VERB
admet-155	94	10	a	a	DET
admet-155	94	11	chiral	chiral	ADJ
admet-155	94	12	environment	environment	NOUN
admet-155	94	13	,	,	PUNCT
admet-155	94	14	therefore	therefore	ADV
admet-155	94	15	there	there	PRON
admet-155	94	16	is	be	VERB
admet-155	94	17	potential	potential	ADJ
admet-155	94	18	for	for	ADP
admet-155	94	19	stereoselective	stereoselective	ADJ
admet-155	94	20	interactions	interaction	NOUN
admet-155	94	21	of	of	ADP
admet-155	94	22	an	an	DET
admet-155	94	23	enhancer	enhancer	NOUN
admet-155	94	24	with	with	ADP
admet-155	94	25	skin	skin	NOUN
admet-155	94	26	components	component	NOUN
admet-155	94	27	.	.	PUNCT
admet-155	95	1	stereoselective	stereoselective	ADJ
admet-155	95	2	interactions	interaction	NOUN
admet-155	95	3	of	of	ADP
admet-155	95	4	individual	individual	ADJ
admet-155	95	5	drug	drug	NOUN
admet-155	95	6	enantiomers	enantiomer	NOUN
admet-155	95	7	(	(	PUNCT
admet-155	95	8	e.g.	e.g.	ADV
admet-155	95	9	,	,	PUNCT
admet-155	95	10	propranolol	propranolol	NOUN
admet-155	95	11	,	,	PUNCT
admet-155	95	12	metoprolol	metoprolol	PROPN
admet-155	95	13	,	,	PUNCT
admet-155	95	14	timolol	timolol	PROPN
admet-155	95	15	,	,	PUNCT
admet-155	95	16	ketorolac	ketorolac	PROPN
admet-155	95	17	,	,	PUNCT
admet-155	95	18	ketoprofen	ketoprofen	NOUN
admet-155	95	19	,	,	PUNCT
admet-155	95	20	flurbiprofen	flurbiprofen	NOUN
admet-155	95	21	,	,	PUNCT
admet-155	95	22	ephedrine	ephedrine	NOUN
admet-155	95	23	,	,	PUNCT
admet-155	95	24	oxybutynin	oxybutynin	PROPN
admet-155	95	25	,	,	PUNCT
admet-155	95	26	amlodipine	amlodipine	NOUN
admet-155	95	27	)	)	PUNCT
admet-155	95	28	with	with	ADP
admet-155	95	29	the	the	DET
admet-155	95	30	skin	skin	NOUN
admet-155	95	31	components	component	NOUN
admet-155	95	32	involving	involve	VERB
admet-155	95	33	different	different	ADJ
admet-155	95	34	permeation	permeation	NOUN
admet-155	95	35	rates	rate	NOUN
admet-155	95	36	of	of	ADP
admet-155	95	37	individual	individual	ADJ
admet-155	95	38	enantiomers	enantiomer	NOUN
admet-155	95	39	through	through	ADP
admet-155	95	40	the	the	DET
admet-155	95	41	skin	skin	NOUN
admet-155	95	42	were	be	AUX
admet-155	95	43	tested	test	VERB
admet-155	95	44	.	.	PUNCT
admet-155	96	1	some	some	DET
admet-155	96	2	authors	author	NOUN
admet-155	96	3	found	find	VERB
admet-155	96	4	different	different	ADJ
admet-155	96	5	permeation	permeation	NOUN
admet-155	96	6	rates	rate	NOUN
admet-155	96	7	for	for	ADP
admet-155	96	8	enantiomers	enantiomer	NOUN
admet-155	96	9	,	,	PUNCT
admet-155	96	10	while	while	SCONJ
admet-155	96	11	other	other	ADJ
admet-155	96	12	studies	study	NOUN
admet-155	96	13	showed	show	VERB
admet-155	96	14	no	no	DET
admet-155	96	15	enantiomeric	enantiomeric	ADJ
admet-155	96	16	differences	difference	NOUN
admet-155	96	17	in	in	ADP
admet-155	96	18	the	the	DET
admet-155	96	19	permeation	permeation	NOUN
admet-155	96	20	[	[	X
admet-155	96	21	20−22,34−36	20−22,34−36	NUM
admet-155	96	22	]	]	PUNCT
admet-155	96	23	.	.	PUNCT
admet-155	97	1	similarly	similarly	ADV
admet-155	97	2	,	,	PUNCT
admet-155	97	3	investigations	investigation	NOUN
admet-155	97	4	of	of	ADP
admet-155	97	5	interactions	interaction	NOUN
admet-155	97	6	of	of	ADP
admet-155	97	7	individual	individual	ADJ
admet-155	97	8	cpe	cpe	NOUN
admet-155	97	9	enantiomers	enantiomer	NOUN
admet-155	97	10	with	with	ADP
admet-155	97	11	the	the	DET
admet-155	97	12	skin	skin	NOUN
admet-155	97	13	provided	provide	VERB
admet-155	97	14	opposite	opposite	ADJ
admet-155	97	15	results	result	NOUN
admet-155	97	16	[	[	X
admet-155	97	17	20,22,37,38	20,22,37,38	NUM
admet-155	97	18	]	]	PUNCT
admet-155	97	19	;	;	PUNCT
admet-155	97	20	therefore	therefore	ADV
admet-155	97	21	additional	additional	ADJ
admet-155	97	22	studies	study	NOUN
admet-155	97	23	are	be	AUX
admet-155	97	24	needed	need	VERB
admet-155	97	25	to	to	PART
admet-155	97	26	be	be	AUX
admet-155	97	27	performed	perform	VERB
admet-155	97	28	to	to	PART
admet-155	97	29	answer	answer	VERB
admet-155	97	30	whether	whether	SCONJ
admet-155	97	31	the	the	DET
admet-155	97	32	skin	skin	NOUN
admet-155	97	33	is	be	AUX
admet-155	97	34	an	an	DET
admet-155	97	35	enantioselective	enantioselective	ADJ
admet-155	97	36	membrane	membrane	NOUN
admet-155	97	37	and	and	CCONJ
admet-155	97	38	given	give	VERB
admet-155	97	39	its	its	PRON
admet-155	97	40	mechanism	mechanism	NOUN
admet-155	97	41	of	of	ADP
admet-155	97	42	action	action	NOUN
admet-155	97	43	,	,	PUNCT
admet-155	97	44	enhancer	enhancer	NOUN
admet-155	97	45	conformation	conformation	NOUN
admet-155	97	46	can	can	AUX
admet-155	97	47	influence	influence	VERB
admet-155	97	48	its	its	PRON
admet-155	97	49	enhancing	enhance	VERB
admet-155	97	50	properties	property	NOUN
admet-155	97	51	or	or	CCONJ
admet-155	97	52	the	the	DET
admet-155	97	53	differences	difference	NOUN
admet-155	97	54	in	in	ADP
admet-155	97	55	the	the	DET
admet-155	97	56	permeation	permeation	NOUN
admet-155	97	57	rates	rate	NOUN
admet-155	97	58	between	between	ADP
admet-155	97	59	the	the	DET
admet-155	97	60	individual	individual	ADJ
admet-155	97	61	enantiomers	enantiomer	NOUN
admet-155	97	62	are	be	AUX
admet-155	97	63	not	not	PART
admet-155	97	64	related	relate	VERB
admet-155	97	65	to	to	ADP
admet-155	97	66	any	any	DET
admet-155	97	67	stereoselective	stereoselective	ADJ
admet-155	97	68	interactions	interaction	NOUN
admet-155	97	69	,	,	PUNCT
admet-155	97	70	but	but	CCONJ
admet-155	97	71	they	they	PRON
admet-155	97	72	can	can	AUX
admet-155	97	73	be	be	AUX
admet-155	97	74	explained	explain	VERB
admet-155	97	75	only	only	ADV
admet-155	97	76	by	by	ADP
admet-155	97	77	different	different	ADJ
admet-155	97	78	physicochemical	physicochemical	ADJ
admet-155	97	79	properties	property	NOUN
admet-155	97	80	.	.	PUNCT
admet-155	98	1	conclusions	conclusion	NOUN
admet-155	98	2	the	the	DET
admet-155	98	3	ability	ability	NOUN
admet-155	98	4	of	of	ADP
admet-155	98	5	(	(	PUNCT
admet-155	98	6	s)and	s)and	PROPN
admet-155	98	7	(	(	PUNCT
admet-155	98	8	r)-alaptide	r)-alaptide	VERB
admet-155	98	9	to	to	PART
admet-155	98	10	modify	modify	VERB
admet-155	98	11	the	the	DET
admet-155	98	12	permeation	permeation	NOUN
admet-155	98	13	of	of	ADP
admet-155	98	14	rutin	rutin	NOUN
admet-155	98	15	through	through	ADP
admet-155	98	16	the	the	DET
admet-155	98	17	porcine	porcine	NOUN
admet-155	98	18	ear	ear	NOUN
admet-155	98	19	skin	skin	NOUN
admet-155	98	20	was	be	AUX
admet-155	98	21	examined	examine	VERB
admet-155	98	22	using	use	VERB
admet-155	98	23	the	the	DET
admet-155	98	24	franz	franz	NOUN
admet-155	98	25	cell	cell	NOUN
admet-155	98	26	in	in	ADP
admet-155	98	27	the	the	DET
admet-155	98	28	rapid	rapid	ADJ
admet-155	98	29	in	in	ADP
admet-155	98	30	vitro	vitro	X
admet-155	98	31	screening	screen	VERB
admet-155	98	32	.	.	PUNCT
admet-155	99	1	both	both	DET
admet-155	99	2	enantiomers	enantiomer	NOUN
admet-155	99	3	of	of	ADP
admet-155	99	4	alaptide	alaptide	NOUN
admet-155	99	5	applied	apply	VERB
admet-155	99	6	in	in	ADP
admet-155	99	7	concentration	concentration	NOUN
admet-155	99	8	1	1	NUM
admet-155	99	9	%	%	NOUN
admet-155	99	10	w	w	PROPN
admet-155	99	11	/	/	SYM
admet-155	99	12	w	w	NOUN
admet-155	99	13	related	relate	VERB
admet-155	99	14	to	to	ADP
admet-155	99	15	the	the	DET
admet-155	99	16	amount	amount	NOUN
admet-155	99	17	of	of	ADP
admet-155	99	18	rutin	rutin	NOUN
admet-155	99	19	influenced	influence	VERB
admet-155	99	20	the	the	DET
admet-155	99	21	permeation	permeation	NOUN
admet-155	99	22	of	of	ADP
admet-155	99	23	the	the	DET
admet-155	99	24	drug	drug	NOUN
admet-155	99	25	from	from	ADP
admet-155	99	26	the	the	DET
admet-155	99	27	carboxymethyl	carboxymethyl	NOUN
admet-155	99	28	cellulose	cellulose	NOUN
admet-155	99	29	gel	gel	NOUN
admet-155	99	30	through	through	ADP
admet-155	99	31	the	the	DET
admet-155	99	32	skin	skin	NOUN
admet-155	99	33	.	.	PUNCT
admet-155	100	1	according	accord	VERB
admet-155	100	2	to	to	ADP
admet-155	100	3	the	the	DET
admet-155	100	4	calculated	calculate	VERB
admet-155	100	5	cumulative	cumulative	ADJ
admet-155	100	6	permeated	permeate	VERB
admet-155	100	7	amount	amount	NOUN
admet-155	100	8	of	of	ADP
admet-155	100	9	the	the	DET
admet-155	100	10	drug	drug	NOUN
admet-155	100	11	per	per	ADP
admet-155	100	12	unit	unit	NOUN
admet-155	100	13	of	of	ADP
admet-155	100	14	skin	skin	NOUN
admet-155	100	15	surface	surface	NOUN
admet-155	100	16	area	area	NOUN
admet-155	100	17	in	in	ADP
admet-155	100	18	time	time	NOUN
admet-155	100	19	,	,	PUNCT
admet-155	100	20	rutin	rutin	NOUN
admet-155	100	21	with	with	ADP
admet-155	100	22	addition	addition	NOUN
admet-155	100	23	of	of	ADP
admet-155	100	24	the	the	PRON
admet-155	100	25	(	(	PUNCT
admet-155	100	26	r)-enantiomer	r)-enantiomer	NOUN
admet-155	100	27	of	of	ADP
admet-155	100	28	alaptide	alaptide	NOUN
admet-155	100	29	permeated	permeate	VERB
admet-155	100	30	1.22	1.22	NUM
admet-155	100	31	-	-	NUM
admet-155	100	32	fold	fold	VERB
admet-155	100	33	more	more	ADJ
admet-155	100	34	than	than	ADP
admet-155	100	35	from	from	ADP
admet-155	100	36	the	the	DET
admet-155	100	37	formulation	formulation	NOUN
admet-155	100	38	without	without	ADP
admet-155	100	39	the	the	DET
admet-155	100	40	alaptide	alaptide	ADJ
admet-155	100	41	enantiomers	enantiomer	NOUN
admet-155	100	42	,	,	PUNCT
admet-155	100	43	and	and	CCONJ
admet-155	100	44	with	with	ADP
admet-155	100	45	addition	addition	NOUN
admet-155	100	46	of	of	ADP
admet-155	100	47	the	the	PRON
admet-155	100	48	(	(	PUNCT
admet-155	100	49	s)-enantiomer	s)-enantiomer	NOUN
admet-155	100	50	of	of	ADP
admet-155	100	51	alaptide	alaptide	ADV
admet-155	100	52	permeated	permeate	VERB
admet-155	100	53	1.54	1.54	NUM
admet-155	100	54	-	-	NUM
admet-155	100	55	fold	fold	VERB
admet-155	100	56	more	more	ADV
admet-155	100	57	than	than	ADP
admet-155	100	58	without	without	ADP
admet-155	100	59	the	the	DET
admet-155	100	60	alaptide	alaptide	ADJ
admet-155	100	61	enantiomers	enantiomer	NOUN
admet-155	100	62	.	.	PUNCT
admet-155	101	1	the	the	DET
admet-155	101	2	permeation	permeation	NOUN
admet-155	101	3	of	of	ADP
admet-155	101	4	rutin	rutin	NOUN
admet-155	101	5	through	through	ADP
admet-155	101	6	the	the	DET
admet-155	101	7	skin	skin	NOUN
admet-155	101	8	increased	increase	VERB
admet-155	101	9	approximately	approximately	ADV
admet-155	101	10	linearly	linearly	ADV
admet-155	101	11	with	with	ADP
admet-155	101	12	time	time	NOUN
admet-155	101	13	.	.	PUNCT
admet-155	102	1	it	it	PRON
admet-155	102	2	can	can	AUX
admet-155	102	3	be	be	AUX
admet-155	102	4	concluded	conclude	VERB
admet-155	102	5	that	that	SCONJ
admet-155	102	6	the	the	DET
admet-155	102	7	presence	presence	NOUN
admet-155	102	8	of	of	ADP
admet-155	102	9	alaptide	alaptide	ADJ
admet-155	102	10	facilitated	facilitate	VERB
admet-155	102	11	permeation	permeation	NOUN
admet-155	102	12	of	of	ADP
admet-155	102	13	rutin	rutin	NOUN
admet-155	102	14	.	.	PUNCT
admet-155	103	1	acknowledgements	acknowledgement	NOUN
admet-155	103	2	:	:	PUNCT
admet-155	103	3	this	this	DET
admet-155	103	4	study	study	NOUN
admet-155	103	5	was	be	AUX
admet-155	103	6	supported	support	VERB
admet-155	103	7	by	by	ADP
admet-155	103	8	the	the	DET
admet-155	103	9	centralized	centralized	ADJ
admet-155	103	10	development	development	NOUN
admet-155	103	11	project	project	NOUN
admet-155	103	12	“	"	PUNCT
admet-155	103	13	improving	improve	VERB
admet-155	103	14	qualification	qualification	NOUN
admet-155	103	15	of	of	ADP
admet-155	103	16	students	student	NOUN
admet-155	103	17	of	of	ADP
admet-155	103	18	ph.d	ph.d	PROPN
admet-155	103	19	.	.	PUNCT
admet-155	104	1	educational	educational	ADJ
admet-155	104	2	programs	program	NOUN
admet-155	104	3	&	&	CCONJ
admet-155	104	4	postdoctorates	postdoctorate	NOUN
admet-155	104	5	of	of	ADP
admet-155	104	6	agricultural	agricultural	ADJ
admet-155	104	7	and	and	CCONJ
admet-155	104	8	veterinary	veterinary	ADJ
admet-155	104	9	branches	branch	NOUN
admet-155	104	10	through	through	ADP
admet-155	104	11	engagement	engagement	NOUN
admet-155	104	12	in	in	ADP
admet-155	104	13	multidisciplinary	multidisciplinary	ADJ
admet-155	104	14	interuniversity	interuniversity	NOUN
admet-155	104	15	teams	team	NOUN
admet-155	104	16	”	"	PUNCT
admet-155	104	17	.	.	PUNCT
admet-155	105	1	(	(	PUNCT
admet-155	105	2	studie	studie	PROPN
admet-155	105	3	byla	byla	PROPN
admet-155	105	4	finančně	finančně	PROPN
admet-155	105	5	podpořena	podpořena	PROPN
admet-155	105	6	centralizovaným	centralizovaným	AUX
admet-155	105	7	rozvojovým	rozvojovým	VERB
admet-155	105	8	projektem	projektem	NOUN
admet-155	105	9	“	"	PUNCT
admet-155	105	10	zvyšování	zvyšování	PROPN
admet-155	105	11	kvalifikace	kvalifikace	PROPN
admet-155	105	12	studentů	studentů	PROPN
admet-155	105	13	doktorských	doktorských	PROPN
admet-155	105	14	studijních	studijních	PROPN
admet-155	105	15	programů	programů	PROPN
admet-155	105	16	a	a	DET
admet-155	105	17	post	post	ADJ
admet-155	105	18	-	-	NOUN
admet-155	105	19	doktorandů	doktorandů	NOUN
admet-155	105	20	zemědělských	zemědělských	NOUN
admet-155	105	21	a	a	DET
admet-155	105	22	veterinárních	veterinárních	ADJ
admet-155	105	23	oborů	oborů	NOUN
admet-155	105	24	zapojením	zapojením	PROPN
admet-155	105	25	do	do	VERB
admet-155	105	26	multidisciplinárních	multidisciplinárních	ADJ
admet-155	105	27	meziuniverzitních	meziuniverzitních	PROPN
admet-155	105	28	týmů	týmů	PROPN
admet-155	105	29	”	"	PUNCT
admet-155	105	30	.	.	PUNCT
admet-155	105	31	)	)	PUNCT
admet-155	106	1	references	reference	NOUN
admet-155	106	2	[	[	X
admet-155	106	3	1	1	NUM
admet-155	106	4	]	]	X
admet-155	106	5	h.y	h.y	PROPN
admet-155	106	6	.	.	PROPN
admet-155	106	7	thong	thong	PROPN
admet-155	106	8	,	,	PUNCT
admet-155	106	9	h.	h.	PROPN
admet-155	106	10	zhai	zhai	PROPN
admet-155	106	11	,	,	PUNCT
admet-155	106	12	h.i	h.i	PROPN
admet-155	106	13	.	.	PROPN
admet-155	106	14	maibach	maibach	PROPN
admet-155	106	15	,	,	PUNCT
admet-155	106	16	skin	skin	NOUN
admet-155	106	17	pharmacology	pharmacology	NOUN
admet-155	106	18	and	and	CCONJ
admet-155	106	19	physiology	physiology	NOUN
admet-155	106	20	20	20	NUM
admet-155	106	21	(	(	PUNCT
admet-155	106	22	2007	2007	NUM
admet-155	106	23	)	)	PUNCT
admet-155	106	24	272	272	NUM
admet-155	106	25	-	-	SYM
admet-155	106	26	282	282	NUM
admet-155	106	27	.	.	PUNCT
admet-155	107	1	[	[	X
admet-155	107	2	2	2	X
admet-155	107	3	]	]	X
admet-155	107	4	i.b	i.b	PROPN
admet-155	107	5	.	.	PROPN
admet-155	107	6	pathan	pathan	PROPN
admet-155	107	7	,	,	PUNCT
admet-155	107	8	c.m	c.m	PROPN
admet-155	107	9	setty	setty	NOUN
admet-155	107	10	,	,	PUNCT
admet-155	107	11	tropical	tropical	ADJ
admet-155	107	12	journal	journal	NOUN
admet-155	107	13	of	of	ADP
admet-155	107	14	pharmaceutical	pharmaceutical	ADJ
admet-155	107	15	research	research	NOUN
admet-155	107	16	8	8	NUM
admet-155	107	17	(	(	PUNCT
admet-155	107	18	2009	2009	NUM
admet-155	107	19	)	)	PUNCT
admet-155	107	20	173	173	NUM
admet-155	107	21	-	-	SYM
admet-155	107	22	179	179	NUM
admet-155	107	23	.	.	PUNCT
admet-155	108	1	[	[	X
admet-155	108	2	3	3	X
admet-155	108	3	]	]	X
admet-155	108	4	r.k	r.k	PROPN
admet-155	108	5	.	.	PROPN
admet-155	108	6	subedi	subedi	PROPN
admet-155	108	7	,	,	PUNCT
admet-155	108	8	s.y	s.y	PROPN
admet-155	108	9	.	.	PROPN
admet-155	109	1	oh	oh	INTJ
admet-155	109	2	,	,	PUNCT
admet-155	109	3	m.k	m.k	PROPN
admet-155	109	4	.	.	PUNCT
admet-155	110	1	chun	chun	PROPN
admet-155	110	2	,	,	PUNCT
admet-155	110	3	h.k	h.k	PROPN
admet-155	110	4	.	.	PROPN
admet-155	110	5	choi	choi	PROPN
admet-155	110	6	,	,	PUNCT
admet-155	110	7	archives	archive	NOUN
admet-155	110	8	of	of	ADP
admet-155	110	9	pharmacal	pharmacal	ADJ
admet-155	110	10	research	research	NOUN
admet-155	110	11	33	33	NUM
admet-155	110	12	(	(	PUNCT
admet-155	110	13	2010	2010	NUM
admet-155	110	14	)	)	PUNCT
admet-155	110	15	339	339	NUM
admet-155	110	16	-	-	SYM
admet-155	110	17	351	351	NUM
admet-155	110	18	.	.	PUNCT
admet-155	111	1	[	[	X
admet-155	111	2	4	4	X
admet-155	111	3	]	]	PUNCT
admet-155	111	4	j.	j.	PROPN
admet-155	111	5	jampilek	jampilek	PROPN
admet-155	111	6	,	,	PUNCT
admet-155	111	7	k.	k.	PROPN
admet-155	111	8	brychtova	brychtova	PROPN
admet-155	111	9	,	,	PUNCT
admet-155	111	10	medicinal	medicinal	ADJ
admet-155	111	11	research	research	NOUN
admet-155	111	12	reviews	review	NOUN
admet-155	111	13	32	32	NUM
admet-155	111	14	(	(	PUNCT
admet-155	111	15	2012	2012	NUM
admet-155	111	16	)	)	PUNCT
admet-155	112	1	907–947	907–947	NUM
admet-155	112	2	.	.	PUNCT
admet-155	113	1	[	[	X
admet-155	113	2	5	5	X
admet-155	113	3	]	]	PUNCT
admet-155	113	4	j.	j.	PROPN
admet-155	113	5	jampilek	jampilek	PROPN
admet-155	113	6	,	,	PUNCT
admet-155	113	7	journal	journal	NOUN
admet-155	113	8	of	of	ADP
admet-155	113	9	bioequivalence	bioequivalence	NOUN
admet-155	113	10	&	&	CCONJ
admet-155	113	11	bioavailability	bioavailability	NOUN
admet-155	113	12	5	5	NUM
admet-155	113	13	(	(	PUNCT
admet-155	113	14	2013	2013	NUM
admet-155	113	15	)	)	PUNCT
admet-155	113	16	233–235	233–235	NUM
admet-155	113	17	.	.	PUNCT
admet-155	114	1	[	[	X
admet-155	114	2	6	6	NUM
admet-155	114	3	]	]	X
admet-155	114	4	d.	d.	PROPN
admet-155	114	5	kaushik	kaushik	PROPN
admet-155	114	6	,	,	PUNCT
admet-155	114	7	p.	p.	PROPN
admet-155	114	8	batheja	batheja	PROPN
admet-155	114	9	,	,	PUNCT
admet-155	114	10	b.	b.	PROPN
admet-155	114	11	kilfoyle	kilfoyle	PROPN
admet-155	114	12	,	,	PUNCT
admet-155	114	13	v.	v.	PROPN
admet-155	114	14	rai	rai	PROPN
admet-155	114	15	,	,	PUNCT
admet-155	114	16	b.	b.	PROPN
admet-155	114	17	michniak	michniak	PROPN
admet-155	114	18	-	-	PUNCT
admet-155	114	19	kohn	kohn	PROPN
admet-155	114	20	,	,	PUNCT
admet-155	114	21	expert	expert	ADJ
admet-155	114	22	opinion	opinion	NOUN
admet-155	114	23	drug	drug	NOUN
admet-155	114	24	delivery	delivery	NOUN
admet-155	114	25	5	5	NUM
admet-155	114	26	(	(	PUNCT
admet-155	114	27	2008	2008	NUM
admet-155	114	28	)	)	PUNCT
admet-155	115	1	517–529	517–529	NUM
admet-155	115	2	.	.	PUNCT
admet-155	116	1	[	[	X
admet-155	116	2	7	7	X
admet-155	116	3	]	]	X
admet-155	116	4	e.	e.	PROPN
admet-155	116	5	kasafirek	kasafirek	PROPN
admet-155	116	6	,	,	PUNCT
admet-155	116	7	j.	j.	PROPN
admet-155	116	8	vanzura	vanzura	PROPN
admet-155	116	9	,	,	PUNCT
admet-155	116	10	i.	i.	PROPN
admet-155	116	11	krejci	krejci	PROPN
admet-155	116	12	,	,	PUNCT
admet-155	116	13	j.	j.	PROPN
admet-155	116	14	krepelka	krepelka	PROPN
admet-155	116	15	,	,	PUNCT
admet-155	116	16	a.	a.	NOUN
admet-155	116	17	dlabac	dlabac	NOUN
admet-155	116	18	,	,	PUNCT
admet-155	116	19	m.	m.	NOUN
admet-155	116	20	valchar	valchar	PROPN
admet-155	116	21	,	,	PUNCT
admet-155	116	22	(	(	PUNCT
admet-155	116	23	united	united	ADJ
admet-155	116	24	pharmaceutical	pharmaceutical	PROPN
admet-155	116	25	works	works	PROPN
admet-155	116	26	&	&	CCONJ
admet-155	116	27	research	research	PROPN
admet-155	116	28	institute	institute	PROPN
admet-155	116	29	for	for	ADP
admet-155	116	30	pharmacy	pharmacy	NOUN
admet-155	116	31	and	and	CCONJ
admet-155	116	32	biochemistry	biochemistry	NOUN
admet-155	116	33	)	)	PUNCT
admet-155	116	34	,	,	PUNCT
admet-155	116	35	belg	belg	PROPN
admet-155	116	36	.	.	PUNCT
admet-155	117	1	897843	897843	NUM
admet-155	117	2	(	(	PUNCT
admet-155	117	3	1984	1984	NUM
admet-155	117	4	)	)	PUNCT
admet-155	117	5	&	&	CCONJ
admet-155	117	6	cs	cs	PROPN
admet-155	117	7	231227	231227	NUM
admet-155	117	8	(	(	PUNCT
admet-155	117	9	1986	1986	NUM
admet-155	117	10	)	)	PUNCT
admet-155	117	11	.	.	PUNCT
admet-155	118	1	[	[	X
admet-155	118	2	8	8	X
admet-155	118	3	]	]	X
admet-155	118	4	s.	s.	PROPN
admet-155	118	5	radl	radl	PROPN
admet-155	118	6	,	,	PUNCT
admet-155	118	7	e.	e.	PROPN
admet-155	118	8	kasafirek	kasafirek	PROPN
admet-155	118	9	,	,	PUNCT
admet-155	118	10	i.	i.	PROPN
admet-155	118	11	krejci	krejci	PROPN
admet-155	118	12	,	,	PUNCT
admet-155	118	13	drugs	drug	NOUN
admet-155	118	14	of	of	ADP
admet-155	118	15	the	the	DET
admet-155	118	16	future	future	ADJ
admet-155	118	17	15	15	NUM
admet-155	118	18	(	(	PUNCT
admet-155	118	19	1990	1990	NUM
admet-155	118	20	)	)	PUNCT
admet-155	118	21	445–447	445–447	NUM
admet-155	118	22	.	.	PUNCT
admet-155	119	1	[	[	X
admet-155	119	2	9	9	NUM
admet-155	119	3	]	]	X
admet-155	119	4	r.	r.	PROPN
admet-155	119	5	lapka	lapka	PROPN
admet-155	119	6	,	,	PUNCT
admet-155	119	7	journal	journal	NOUN
admet-155	119	8	of	of	ADP
admet-155	119	9	pharmacy	pharmacy	NOUN
admet-155	119	10	and	and	CCONJ
admet-155	119	11	pharmacology	pharmacology	NOUN
admet-155	119	12	,	,	PUNCT
admet-155	119	13	43	43	NUM
admet-155	119	14	(	(	PUNCT
admet-155	119	15	1991	1991	NUM
admet-155	119	16	)	)	PUNCT
admet-155	119	17	874	874	NUM
admet-155	119	18	-	-	SYM
admet-155	119	19	876	876	NUM
admet-155	119	20	.	.	PUNCT
admet-155	120	1	[	[	X
admet-155	120	2	10	10	NUM
admet-155	120	3	]	]	X
admet-155	120	4	j.	j.	PROPN
admet-155	120	5	jampilek	jampilek	PROPN
admet-155	120	6	,	,	PUNCT
admet-155	120	7	r.	r.	PROPN
admet-155	120	8	opatrilova	opatrilova	PROPN
admet-155	120	9	,	,	PUNCT
admet-155	120	10	a.	a.	NOUN
admet-155	120	11	rezacova	rezacova	PROPN
admet-155	120	12	,	,	PUNCT
admet-155	120	13	z	z	NOUN
admet-155	120	14	oktabec	oktabec	NOUN
admet-155	120	15	,	,	PUNCT
admet-155	120	16	j.	j.	PROPN
admet-155	120	17	dohnal	dohnal	PROPN
admet-155	120	18	,	,	PUNCT
admet-155	120	19	(	(	PUNCT
admet-155	120	20	faculty	faculty	NOUN
admet-155	120	21	of	of	ADP
admet-155	120	22	pharmacy	pharmacy	NOUN
admet-155	120	23	,	,	PUNCT
admet-155	120	24	university	university	NOUN
admet-155	120	25	of	of	ADP
admet-155	120	26	veterinary	veterinary	ADJ
admet-155	120	27	and	and	CCONJ
admet-155	120	28	pharmaceutical	pharmaceutical	NOUN
admet-155	120	29	sciences	science	NOUN
admet-155	120	30	brno	brno	NOUN
admet-155	120	31	)	)	PUNCT
admet-155	120	32	,	,	PUNCT
admet-155	120	33	wo/2014/019556	wo/2014/019556	PROPN
admet-155	120	34	a1	a1	NOUN
admet-155	120	35	(	(	PUNCT
admet-155	120	36	2014	2014	NUM
admet-155	120	37	)	)	PUNCT
admet-155	120	38	.	.	PUNCT
admet-155	121	1	admet	admet	PROPN
admet-155	121	2	&	&	CCONJ
admet-155	121	3	dmpk	dmpk	PROPN
admet-155	121	4	2(4	2(4	NUM
admet-155	121	5	)	)	PUNCT
admet-155	121	6	(	(	PUNCT
admet-155	121	7	2014	2014	NUM
admet-155	121	8	)	)	PUNCT
admet-155	121	9	248	248	NUM
admet-155	121	10	-	-	SYM
admet-155	121	11	253	253	NUM
admet-155	121	12	rutin	rutin	NOUN
admet-155	121	13	permeation	permeation	NOUN
admet-155	121	14	enhancement	enhancement	NOUN
admet-155	121	15	by	by	ADP
admet-155	121	16	alaptide	alaptide	ADJ
admet-155	121	17	enantiomers	enantiomer	NOUN
admet-155	121	18	doi	doi	NOUN
admet-155	121	19	:	:	PUNCT
admet-155	121	20	10.5599	10.5599	NUM
admet-155	121	21	/	/	SYM
admet-155	121	22	admet.2.4.155	admet.2.4.155	PROPN
admet-155	121	23	253	253	NUM
admet-155	122	1	[	[	X
admet-155	122	2	11	11	NUM
admet-155	122	3	]	]	X
admet-155	122	4	j.a	j.a	PROPN
admet-155	122	5	.	.	PROPN
admet-155	122	6	mcgrath	mcgrath	PROPN
admet-155	122	7	,	,	PUNCT
admet-155	122	8	r.a	r.a	PROPN
admet-155	122	9	.	.	PROPN
admet-155	122	10	eady	eady	PROPN
admet-155	122	11	,	,	PUNCT
admet-155	122	12	f.m	f.m	PROPN
admet-155	122	13	.	.	PROPN
admet-155	122	14	pope	pope	PROPN
admet-155	122	15	,	,	PUNCT
admet-155	122	16	rook	rook	NOUN
admet-155	122	17	's	's	PART
admet-155	122	18	textbook	textbook	NOUN
admet-155	122	19	of	of	ADP
admet-155	122	20	dermatology	dermatology	NOUN
admet-155	122	21	,	,	PUNCT
admet-155	122	22	7th	7th	ADJ
admet-155	122	23	ed	ed	NOUN
admet-155	122	24	.	.	PUNCT
admet-155	123	1	t.	t.	NOUN
admet-155	123	2	burns	burn	NOUN
admet-155	123	3	,	,	PUNCT
admet-155	123	4	s.	s.	PROPN
admet-155	123	5	breathnach	breathnach	PROPN
admet-155	123	6	,	,	PUNCT
admet-155	123	7	n.	n.	PROPN
admet-155	123	8	cox	cox	PROPN
admet-155	123	9	,	,	PUNCT
admet-155	123	10	c.	c.	PROPN
admet-155	123	11	griffiths	griffiths	PROPN
admet-155	123	12	,	,	PUNCT
admet-155	123	13	(	(	PUNCT
admet-155	123	14	eds	ed	NOUN
admet-155	123	15	)	)	PUNCT
admet-155	123	16	.	.	PUNCT
admet-155	123	17	,	,	PUNCT
admet-155	123	18	blackwell	blackwell	PROPN
admet-155	123	19	publishing	publishing	NOUN
admet-155	123	20	,	,	PUNCT
admet-155	123	21	oxford	oxford	PROPN
admet-155	123	22	,	,	PUNCT
admet-155	123	23	2004	2004	NUM
admet-155	123	24	,	,	PUNCT
admet-155	123	25	pp	pp	ADJ
admet-155	123	26	.	.	PUNCT
admet-155	124	1	3–7	3–7	NUM
admet-155	124	2	.	.	PUNCT
admet-155	125	1	[	[	X
admet-155	125	2	12	12	NUM
admet-155	125	3	]	]	X
admet-155	125	4	w.	w.	PROPN
admet-155	125	5	james	james	PROPN
admet-155	125	6	,	,	PUNCT
admet-155	125	7	t.	t.	PROPN
admet-155	125	8	berger	berger	PROPN
admet-155	125	9	,	,	PUNCT
admet-155	125	10	d.	d.	PROPN
admet-155	125	11	elston	elston	PROPN
admet-155	125	12	.	.	PUNCT
admet-155	125	13	andrews	andrews	PROPN
admet-155	125	14	'	'	PART
admet-155	125	15	diseases	disease	NOUN
admet-155	125	16	of	of	ADP
admet-155	125	17	the	the	DET
admet-155	125	18	skin	skin	NOUN
admet-155	125	19	:	:	PUNCT
admet-155	125	20	clinical	clinical	ADJ
admet-155	125	21	dermatology	dermatology	NOUN
admet-155	125	22	,	,	PUNCT
admet-155	125	23	10th	10th	ADJ
admet-155	125	24	ed	ed	NOUN
admet-155	125	25	.	.	PROPN
admet-155	125	26	,	,	PUNCT
admet-155	125	27	saunders	saunders	PROPN
admet-155	125	28	-	-	PUNCT
admet-155	125	29	elsevier	elsevier	PROPN
admet-155	125	30	,	,	PUNCT
admet-155	125	31	philadelphia	philadelphia	PROPN
admet-155	125	32	,	,	PUNCT
admet-155	125	33	2006	2006	NUM
admet-155	125	34	,	,	PUNCT
admet-155	125	35	pp	pp	ADV
admet-155	125	36	.	.	PUNCT
admet-155	126	1	5–6	5–6	VERB
admet-155	126	2	.	.	PUNCT
admet-155	127	1	[	[	X
admet-155	127	2	13	13	NUM
admet-155	127	3	]	]	SYM
admet-155	127	4	f.m	f.m	PROPN
admet-155	127	5	.	.	PROPN
admet-155	127	6	watt	watt	NOUN
admet-155	127	7	,	,	PUNCT
admet-155	127	8	bioessays	bioessay	VERB
admet-155	127	9	8	8	NUM
admet-155	127	10	(	(	PUNCT
admet-155	127	11	1988	1988	NUM
admet-155	127	12	)	)	PUNCT
admet-155	127	13	163–167	163–167	NUM
admet-155	127	14	.	.	PUNCT
admet-155	128	1	[	[	X
admet-155	128	2	14	14	NUM
admet-155	128	3	]	]	X
admet-155	128	4	j.	j.	PROPN
admet-155	128	5	jampilek	jampilek	PROPN
admet-155	128	6	,	,	PUNCT
admet-155	128	7	r.	r.	PROPN
admet-155	128	8	opatrilova	opatrilova	PROPN
admet-155	128	9	,	,	PUNCT
admet-155	128	10	l.	l.	PROPN
admet-155	128	11	coufalova	coufalova	PROPN
admet-155	128	12	,	,	PUNCT
admet-155	128	13	a.	a.	PROPN
admet-155	128	14	cernikova	cernikova	PROPN
admet-155	128	15	,	,	PUNCT
admet-155	128	16	j.	j.	PROPN
admet-155	128	17	dohnal	dohnal	PROPN
admet-155	128	18	,	,	PUNCT
admet-155	128	19	(	(	PUNCT
admet-155	128	20	faculty	faculty	NOUN
admet-155	128	21	of	of	ADP
admet-155	128	22	pharmacy	pharmacy	NOUN
admet-155	128	23	,	,	PUNCT
admet-155	128	24	university	university	NOUN
admet-155	128	25	of	of	ADP
admet-155	128	26	veterinary	veterinary	ADJ
admet-155	128	27	and	and	CCONJ
admet-155	128	28	pharmaceutical	pharmaceutical	NOUN
admet-155	128	29	sciences	science	NOUN
admet-155	128	30	brno	brno	NOUN
admet-155	128	31	)	)	PUNCT
admet-155	128	32	,	,	PUNCT
admet-155	128	33	wo/2013/020527	wo/2013/020527	PROPN
admet-155	128	34	a1	a1	NOUN
admet-155	128	35	(	(	PUNCT
admet-155	128	36	2013	2013	NUM
admet-155	128	37	)	)	PUNCT
admet-155	128	38	.	.	PUNCT
admet-155	129	1	[	[	X
admet-155	129	2	15	15	NUM
admet-155	129	3	]	]	X
admet-155	129	4	j.	j.	PROPN
admet-155	129	5	jampilek	jampilek	PROPN
admet-155	129	6	,	,	PUNCT
admet-155	129	7	a.	a.	PROPN
admet-155	129	8	cernikova	cernikova	PROPN
admet-155	129	9	,	,	PUNCT
admet-155	129	10	r.	r.	PROPN
admet-155	129	11	opatrilova	opatrilova	PROPN
admet-155	129	12	,	,	PUNCT
admet-155	129	13	j.	j.	PROPN
admet-155	129	14	dohnal	dohnal	PROPN
admet-155	129	15	,	,	PUNCT
admet-155	129	16	(	(	PUNCT
admet-155	129	17	faculty	faculty	NOUN
admet-155	129	18	of	of	ADP
admet-155	129	19	pharmacy	pharmacy	NOUN
admet-155	129	20	,	,	PUNCT
admet-155	129	21	university	university	NOUN
admet-155	129	22	of	of	ADP
admet-155	129	23	veterinary	veterinary	ADJ
admet-155	129	24	and	and	CCONJ
admet-155	129	25	pharmaceutical	pharmaceutical	NOUN
admet-155	129	26	sciences	science	NOUN
admet-155	129	27	brno	brno	NOUN
admet-155	129	28	)	)	PUNCT
admet-155	129	29	,	,	PUNCT
admet-155	129	30	cz	cz	NOUN
admet-155	129	31	pv	pv	ADJ
admet-155	129	32	2013	2013	NUM
admet-155	129	33	-	-	SYM
admet-155	129	34	1000	1000	NUM
admet-155	129	35	(	(	PUNCT
admet-155	129	36	2013	2013	NUM
admet-155	129	37	)	)	PUNCT
admet-155	129	38	.	.	PUNCT
admet-155	130	1	[	[	X
admet-155	130	2	16	16	NUM
admet-155	130	3	]	]	X
admet-155	130	4	j.	j.	PROPN
admet-155	130	5	jampilek	jampilek	PROPN
admet-155	130	6	,	,	PUNCT
admet-155	130	7	r.	r.	PROPN
admet-155	130	8	opatrilova	opatrilova	PROPN
admet-155	130	9	,	,	PUNCT
admet-155	130	10	l.	l.	PROPN
admet-155	130	11	dvorakova	dvorakova	PROPN
admet-155	130	12	,	,	PUNCT
admet-155	130	13	k.	k.	PROPN
admet-155	130	14	brychtova	brychtova	PROPN
admet-155	130	15	,	,	PUNCT
admet-155	130	16	j.	j.	PROPN
admet-155	130	17	dohnal	dohnal	PROPN
admet-155	130	18	,	,	PUNCT
admet-155	130	19	(	(	PUNCT
admet-155	130	20	faculty	faculty	NOUN
admet-155	130	21	of	of	ADP
admet-155	130	22	pharmacy	pharmacy	NOUN
admet-155	130	23	,	,	PUNCT
admet-155	130	24	university	university	NOUN
admet-155	130	25	of	of	ADP
admet-155	130	26	veterinary	veterinary	ADJ
admet-155	130	27	and	and	CCONJ
admet-155	130	28	pharmaceutical	pharmaceutical	NOUN
admet-155	130	29	sciences	science	NOUN
admet-155	130	30	brno	brno	NOUN
admet-155	130	31	)	)	PUNCT
admet-155	130	32	,	,	PUNCT
admet-155	130	33	cz	cz	NOUN
admet-155	130	34	304915	304915	NUM
admet-155	130	35	b6	b6	NOUN
admet-155	130	36	(	(	PUNCT
admet-155	130	37	2014	2014	NUM
admet-155	130	38	)	)	PUNCT
admet-155	130	39	.	.	PUNCT
admet-155	131	1	[	[	X
admet-155	131	2	17	17	NUM
admet-155	131	3	]	]	X
admet-155	131	4	r.	r.	PROPN
admet-155	131	5	opatrilova	opatrilova	PROPN
admet-155	131	6	,	,	PUNCT
admet-155	131	7	a.	a.	PROPN
admet-155	131	8	cernikova	cernikova	PROPN
admet-155	131	9	,	,	PUNCT
admet-155	131	10	l.	l.	PROPN
admet-155	131	11	coufalova	coufalova	PROPN
admet-155	131	12	,	,	PUNCT
admet-155	131	13	j.	j.	PROPN
admet-155	131	14	dohnal	dohnal	PROPN
admet-155	131	15	,	,	PUNCT
admet-155	131	16	j.	j.	PROPN
admet-155	131	17	jampilek	jampilek	PROPN
admet-155	131	18	,	,	PUNCT
admet-155	131	19	the	the	DET
admet-155	131	20	scientific	scientific	ADJ
admet-155	131	21	world	world	NOUN
admet-155	131	22	journal	journal	NOUN
admet-155	131	23	,	,	PUNCT
admet-155	131	24	2013	2013	NUM
admet-155	131	25	(	(	PUNCT
admet-155	131	26	2013	2013	NUM
admet-155	131	27	)	)	PUNCT
admet-155	131	28	,	,	PUNCT
admet-155	131	29	article	article	NOUN
admet-155	131	30	i	i	PROPN
admet-155	131	31	d	d	PROPN
admet-155	131	32	787283	787283	NUM
admet-155	131	33	(	(	PUNCT
admet-155	131	34	8	8	NUM
admet-155	131	35	pages	page	NOUN
admet-155	131	36	)	)	PUNCT
admet-155	131	37	.	.	PUNCT
admet-155	132	1	[	[	X
admet-155	132	2	18	18	NUM
admet-155	132	3	]	]	PUNCT
admet-155	132	4	r.	r.	PROPN
admet-155	132	5	opatrilova	opatrilova	PROPN
admet-155	132	6	,	,	PUNCT
admet-155	132	7	j.	j.	PROPN
admet-155	132	8	jampilek	jampilek	PROPN
admet-155	132	9	,	,	PUNCT
admet-155	132	10	admet	admet	PROPN
admet-155	132	11	&	&	CCONJ
admet-155	132	12	dmpk	dmpk	PROPN
admet-155	132	13	2	2	NUM
admet-155	132	14	(	(	PUNCT
admet-155	132	15	2014	2014	NUM
admet-155	132	16	)	)	PUNCT
admet-155	132	17	56–62	56–62	NUM
admet-155	132	18	.	.	PUNCT
admet-155	133	1	[	[	X
admet-155	133	2	19	19	NUM
admet-155	133	3	]	]	PUNCT
admet-155	133	4	a.	a.	NOUN
admet-155	133	5	cernikova	cernikova	PROPN
admet-155	133	6	,	,	PUNCT
admet-155	133	7	r.	r.	PROPN
admet-155	133	8	opatrilova	opatrilova	PROPN
admet-155	133	9	,	,	PUNCT
admet-155	133	10	j.	j.	PROPN
admet-155	133	11	jampilek	jampilek	PROPN
admet-155	133	12	,	,	PUNCT
admet-155	133	13	military	military	ADJ
admet-155	133	14	medical	medical	ADJ
admet-155	133	15	science	science	NOUN
admet-155	133	16	letters	letter	NOUN
admet-155	133	17	83	83	NUM
admet-155	133	18	(	(	PUNCT
admet-155	133	19	2014	2014	NUM
admet-155	133	20	)	)	PUNCT
admet-155	133	21	34–39	34–39	NUM
admet-155	133	22	.	.	PUNCT
admet-155	134	1	[	[	X
admet-155	134	2	20	20	NUM
admet-155	134	3	]	]	SYM
admet-155	134	4	i.k	i.k	PROPN
admet-155	134	5	.	.	PROPN
admet-155	134	6	reddy	reddy	PROPN
admet-155	134	7	,	,	PUNCT
admet-155	134	8	t.r	t.r	PROPN
admet-155	134	9	.	.	PROPN
admet-155	134	10	kommuru	kommuru	PROPN
admet-155	134	11	,	,	PUNCT
admet-155	134	12	a.a	a.a	PROPN
admet-155	134	13	.	.	PROPN
admet-155	134	14	zaghloul	zaghloul	PROPN
admet-155	134	15	,	,	PUNCT
admet-155	134	16	m.a	m.a	PROPN
admet-155	134	17	.	.	PROPN
admet-155	134	18	khan	khan	PROPN
admet-155	134	19	,	,	PUNCT
admet-155	134	20	critical	critical	ADJ
admet-155	134	21	reviews	review	NOUN
admet-155	134	22	in	in	ADP
admet-155	134	23	therapeutic	therapeutic	ADJ
admet-155	134	24	drug	drug	NOUN
admet-155	134	25	carrier	carrier	NOUN
admet-155	134	26	systems	system	NOUN
admet-155	134	27	17	17	NUM
admet-155	134	28	(	(	PUNCT
admet-155	134	29	2000	2000	NUM
admet-155	134	30	)	)	PUNCT
admet-155	134	31	285–325	285–325	NUM
admet-155	134	32	.	.	PUNCT
admet-155	135	1	[	[	X
admet-155	135	2	21	21	NUM
admet-155	135	3	]	]	X
admet-155	135	4	i.k	i.k	PROPN
admet-155	135	5	.	.	PROPN
admet-155	135	6	reddy	reddy	PROPN
admet-155	135	7	,	,	PUNCT
admet-155	135	8	r.	r.	PROPN
admet-155	135	9	mehvar	mehvar	PROPN
admet-155	135	10	,	,	PUNCT
admet-155	135	11	chirality	chirality	NOUN
admet-155	135	12	in	in	ADP
admet-155	135	13	drug	drug	NOUN
admet-155	135	14	design	design	NOUN
admet-155	135	15	and	and	CCONJ
admet-155	135	16	development	development	NOUN
admet-155	135	17	,	,	PUNCT
admet-155	135	18	marcel	marcel	PROPN
admet-155	135	19	dekker	dekker	PROPN
admet-155	135	20	,	,	PUNCT
admet-155	135	21	new	new	PROPN
admet-155	135	22	york	york	PROPN
admet-155	135	23	,	,	PUNCT
admet-155	135	24	2004	2004	NUM
admet-155	135	25	.	.	PUNCT
admet-155	136	1	[	[	X
admet-155	136	2	22	22	NUM
admet-155	136	3	]	]	PUNCT
admet-155	136	4	k.	k.	PROPN
admet-155	136	5	vavrova	vavrova	PROPN
admet-155	136	6	,	,	PUNCT
admet-155	136	7	j.	j.	PROPN
admet-155	136	8	zbytovska	zbytovska	PROPN
admet-155	136	9	,	,	PUNCT
admet-155	136	10	a.	a.	NOUN
admet-155	136	11	hrabalek	hrabalek	PROPN
admet-155	136	12	,	,	PUNCT
admet-155	136	13	current	current	ADJ
admet-155	136	14	medicinal	medicinal	ADJ
admet-155	136	15	chemistry	chemistry	NOUN
admet-155	136	16	12	12	NUM
admet-155	136	17	(	(	PUNCT
admet-155	136	18	2005	2005	NUM
admet-155	136	19	)	)	PUNCT
admet-155	136	20	2273–2291	2273–2291	NUM
admet-155	136	21	.	.	PUNCT
admet-155	137	1	[	[	X
admet-155	137	2	23	23	NUM
admet-155	137	3	]	]	PUNCT
admet-155	137	4	drug	drug	PROPN
admet-155	137	5	bank	bank	PROPN
admet-155	137	6	ver	ver	PROPN
admet-155	137	7	.	.	PROPN
admet-155	138	1	4.1	4.1	NUM
admet-155	138	2	–	–	PUNCT
admet-155	138	3	rutin	rutin	NOUN
admet-155	138	4	,	,	PUNCT
admet-155	138	5	http://www.drugbank.ca/drugs/db01698	http://www.drugbank.ca/drugs/db01698	NOUN
admet-155	138	6	(	(	PUNCT
admet-155	138	7	december	december	PROPN
admet-155	138	8	12	12	NUM
admet-155	138	9	,	,	PUNCT
admet-155	138	10	2014	2014	NUM
admet-155	138	11	)	)	PUNCT
admet-155	138	12	.	.	PUNCT
admet-155	139	1	[	[	X
admet-155	139	2	24	24	NUM
admet-155	139	3	]	]	PUNCT
admet-155	139	4	a.	a.	NOUN
admet-155	139	5	benthsath	benthsath	PROPN
admet-155	139	6	,	,	PUNCT
admet-155	139	7	s.t	s.t	PROPN
admet-155	139	8	.	.	PROPN
admet-155	139	9	rusznyak	rusznyak	PROPN
admet-155	139	10	,	,	PUNCT
admet-155	139	11	a.	a.	NOUN
admet-155	139	12	szent	szent	NOUN
admet-155	139	13	-	-	PUNCT
admet-155	139	14	gyorgyi	gyorgyi	NOUN
admet-155	139	15	,	,	PUNCT
admet-155	139	16	nature	nature	NOUN
admet-155	139	17	139	139	NUM
admet-155	139	18	(	(	PUNCT
admet-155	139	19	1937	1937	NUM
admet-155	139	20	)	)	PUNCT
admet-155	140	1	326–327	326–327	NUM
admet-155	140	2	.	.	PUNCT
admet-155	141	1	[	[	X
admet-155	141	2	25	25	NUM
admet-155	141	3	]	]	X
admet-155	141	4	q.m	q.m	PROPN
admet-155	141	5	.	.	PROPN
admet-155	141	6	andersen	andersen	PROPN
admet-155	141	7	,	,	PUNCT
admet-155	141	8	k.r	k.r	PROPN
admet-155	141	9	.	.	PROPN
admet-155	141	10	markham	markham	PROPN
admet-155	141	11	.	.	PUNCT
admet-155	142	1	flavonoids	flavonoid	NOUN
admet-155	142	2	:	:	PUNCT
admet-155	142	3	chemistry	chemistry	NOUN
admet-155	142	4	,	,	PUNCT
admet-155	142	5	biochemistry	biochemistry	NOUN
admet-155	142	6	and	and	CCONJ
admet-155	142	7	applications	application	NOUN
admet-155	142	8	.	.	PUNCT
admet-155	143	1	crc	crc	PROPN
admet-155	143	2	press	press	PROPN
admet-155	143	3	,	,	PUNCT
admet-155	143	4	boca	boca	PROPN
admet-155	143	5	raton	raton	PROPN
admet-155	143	6	,	,	PUNCT
admet-155	143	7	2006	2006	NUM
admet-155	143	8	.	.	PUNCT
admet-155	144	1	[	[	X
admet-155	144	2	26	26	NUM
admet-155	144	3	]	]	PUNCT
admet-155	144	4	s.	s.	PROPN
admet-155	144	5	kumar	kumar	PROPN
admet-155	144	6	,	,	PUNCT
admet-155	144	7	a.k	a.k	PROPN
admet-155	144	8	.	.	PROPN
admet-155	144	9	pandey	pandey	PROPN
admet-155	144	10	.	.	PUNCT
admet-155	145	1	the	the	DET
admet-155	145	2	scientific	scientific	ADJ
admet-155	145	3	world	world	NOUN
admet-155	145	4	journal	journal	PROPN
admet-155	145	5	2013	2013	NUM
admet-155	145	6	(	(	PUNCT
admet-155	145	7	2013	2013	NUM
admet-155	145	8	)	)	PUNCT
admet-155	145	9	article	article	NOUN
admet-155	145	10	i	i	PROPN
admet-155	145	11	d	d	PROPN
admet-155	145	12	162750	162750	NUM
admet-155	145	13	(	(	PUNCT
admet-155	145	14	16	16	NUM
admet-155	145	15	pages	page	NOUN
admet-155	145	16	)	)	PUNCT
admet-155	145	17	.	.	PUNCT
admet-155	146	1	[	[	X
admet-155	146	2	27	27	NUM
admet-155	146	3	]	]	X
admet-155	146	4	l.h	l.h	PROPN
admet-155	146	5	.	.	PROPN
admet-155	146	6	cazarolli	cazarolli	PROPN
admet-155	146	7	,	,	PUNCT
admet-155	146	8	l.	l.	PROPN
admet-155	146	9	zanatta	zanatta	PROPN
admet-155	146	10	,	,	PUNCT
admet-155	146	11	e.h	e.h	PROPN
admet-155	146	12	.	.	PROPN
admet-155	146	13	alberton	alberton	PROPN
admet-155	146	14	,	,	PUNCT
admet-155	146	15	m.s	m.s	PROPN
admet-155	146	16	.	.	PROPN
admet-155	146	17	figueiredo	figueiredo	PROPN
admet-155	146	18	,	,	PUNCT
admet-155	146	19	p.	p.	NOUN
admet-155	146	20	folador	folador	PROPN
admet-155	146	21	,	,	PUNCT
admet-155	146	22	r.g	r.g	PROPN
admet-155	146	23	.	.	PROPN
admet-155	146	24	damazio	damazio	PROPN
admet-155	146	25	,	,	PUNCT
admet-155	146	26	m.g	m.g	PROPN
admet-155	146	27	.	.	PROPN
admet-155	146	28	pizzolatti	pizzolatti	PROPN
admet-155	146	29	,	,	PUNCT
admet-155	146	30	f.r	f.r	PROPN
admet-155	146	31	.	.	PROPN
admet-155	146	32	silva	silva	PROPN
admet-155	146	33	,	,	PUNCT
admet-155	146	34	mini	mini	NOUN
admet-155	146	35	-	-	NOUN
admet-155	146	36	reviews	review	NOUN
admet-155	146	37	in	in	ADP
admet-155	146	38	medicinal	medicinal	ADJ
admet-155	146	39	chemistry	chemistry	NOUN
admet-155	146	40	8	8	NUM
admet-155	146	41	(	(	PUNCT
admet-155	146	42	2008	2008	NUM
admet-155	146	43	)	)	PUNCT
admet-155	146	44	1429–1440	1429–1440	NUM
admet-155	146	45	.	.	PUNCT
admet-155	147	1	[	[	X
admet-155	147	2	28	28	NUM
admet-155	147	3	]	]	X
admet-155	147	4	m.s	m.s	PROPN
admet-155	147	5	.	.	PROPN
admet-155	147	6	gohel	gohel	PROPN
admet-155	147	7	,	,	PUNCT
admet-155	147	8	a.h	a.h	PROPN
admet-155	147	9	.	.	PROPN
admet-155	147	10	davies	davy	NOUN
admet-155	147	11	,	,	PUNCT
admet-155	147	12	current	current	ADJ
admet-155	147	13	vascular	vascular	ADJ
admet-155	147	14	pharmacology	pharmacology	NOUN
admet-155	147	15	7	7	NUM
admet-155	147	16	(	(	PUNCT
admet-155	147	17	2009	2009	NUM
admet-155	147	18	)	)	PUNCT
admet-155	147	19	303	303	NUM
admet-155	147	20	-	-	SYM
admet-155	147	21	308	308	NUM
admet-155	147	22	.	.	PUNCT
admet-155	148	1	[	[	X
admet-155	148	2	29	29	NUM
admet-155	148	3	]	]	X
admet-155	148	4	e.	e.	PROPN
admet-155	148	5	kasafirek	kasafirek	PROPN
admet-155	148	6	,	,	PUNCT
admet-155	148	7	m.	m.	NOUN
admet-155	148	8	rybak	rybak	PROPN
admet-155	148	9	,	,	PUNCT
admet-155	148	10	i.	i.	PROPN
admet-155	148	11	krejci	krejci	PROPN
admet-155	148	12	,	,	PUNCT
admet-155	148	13	a.	a.	PROPN
admet-155	148	14	sturs	sturs	PROPN
admet-155	148	15	,	,	PUNCT
admet-155	148	16	e.	e.	PROPN
admet-155	148	17	krepela	krepela	PROPN
admet-155	148	18	,	,	PUNCT
admet-155	148	19	a.	a.	PROPN
admet-155	148	20	sedo	sedo	PROPN
admet-155	148	21	,	,	PUNCT
admet-155	148	22	life	life	NOUN
admet-155	148	23	science	science	NOUN
admet-155	148	24	50	50	NUM
admet-155	148	25	(	(	PUNCT
admet-155	148	26	1992	1992	NUM
admet-155	148	27	)	)	PUNCT
admet-155	148	28	187–193	187–193	NUM
admet-155	148	29	.	.	PUNCT
admet-155	149	1	[	[	X
admet-155	149	2	30	30	NUM
admet-155	149	3	]	]	X
admet-155	149	4	o.	o.	NOUN
admet-155	149	5	julinek	julinek	PROPN
admet-155	149	6	,	,	PUNCT
admet-155	149	7	v.	v.	ADP
admet-155	149	8	setnicka	setnicka	NOUN
admet-155	149	9	,	,	PUNCT
admet-155	149	10	a.	a.	PROPN
admet-155	149	11	rezacova	rezacova	PROPN
admet-155	149	12	,	,	PUNCT
admet-155	149	13	j.	j.	PROPN
admet-155	149	14	dohnal	dohnal	PROPN
admet-155	149	15	,	,	PUNCT
admet-155	149	16	v.	v.	ADP
admet-155	149	17	vosatka	vosatka	NOUN
admet-155	149	18	,	,	PUNCT
admet-155	149	19	m.	m.	NOUN
admet-155	149	20	urbanova	urbanova	PROPN
admet-155	149	21	,	,	PUNCT
admet-155	149	22	journal	journal	NOUN
admet-155	149	23	of	of	ADP
admet-155	149	24	pharmaceutical	pharmaceutical	NOUN
admet-155	149	25	and	and	CCONJ
admet-155	149	26	biomedical	biomedical	ADJ
admet-155	149	27	analysis	analysis	NOUN
admet-155	149	28	53	53	NUM
admet-155	149	29	(	(	PUNCT
admet-155	149	30	2010	2010	NUM
admet-155	149	31	)	)	PUNCT
admet-155	149	32	958–961	958–961	NUM
admet-155	149	33	.	.	PUNCT
admet-155	150	1	[	[	X
admet-155	150	2	31	31	NUM
admet-155	150	3	]	]	PUNCT
admet-155	150	4	e.	e.	PROPN
admet-155	150	5	kasafirek	kasafirek	PROPN
admet-155	150	6	,	,	PUNCT
admet-155	150	7	l.	l.	PROPN
admet-155	150	8	korbova	korbova	PROPN
admet-155	150	9	,	,	PUNCT
admet-155	150	10	j.	j.	PROPN
admet-155	150	11	kohout	kohout	PROPN
admet-155	150	12	,	,	PUNCT
admet-155	150	13	m.	m.	PROPN
admet-155	150	14	jiraskova	jiraskova	PROPN
admet-155	150	15	,	,	PUNCT
admet-155	150	16	i.	i.	PROPN
admet-155	150	17	krejci	krejci	PROPN
admet-155	150	18	,	,	PUNCT
admet-155	150	19	a.	a.	NOUN
admet-155	150	20	galatik	galatik	PROPN
admet-155	150	21	,	,	PUNCT
admet-155	150	22	(	(	PUNCT
admet-155	150	23	united	united	ADJ
admet-155	150	24	pharmaceutical	pharmaceutical	PROPN
admet-155	150	25	works	works	PROPN
admet-155	150	26	&	&	CCONJ
admet-155	150	27	research	research	PROPN
admet-155	150	28	institute	institute	PROPN
admet-155	150	29	for	for	ADP
admet-155	150	30	pharmacy	pharmacy	NOUN
admet-155	150	31	and	and	CCONJ
admet-155	150	32	biochemistry	biochemistry	NOUN
admet-155	150	33	)	)	PUNCT
admet-155	150	34	,	,	PUNCT
admet-155	150	35	cs	cs	PROPN
admet-155	150	36	276270	276270	NUM
admet-155	150	37	(	(	PUNCT
admet-155	150	38	1992	1992	NUM
admet-155	150	39	)	)	PUNCT
admet-155	150	40	.	.	PUNCT
admet-155	151	1	[	[	X
admet-155	151	2	32	32	NUM
admet-155	151	3	]	]	X
admet-155	151	4	t.j	t.j	PROPN
admet-155	151	5	.	.	PROPN
admet-155	151	6	franz	franz	PROPN
admet-155	151	7	,	,	PUNCT
admet-155	151	8	journal	journal	NOUN
admet-155	151	9	of	of	ADP
admet-155	151	10	investigative	investigative	ADJ
admet-155	151	11	dermatology	dermatology	NOUN
admet-155	151	12	64	64	NUM
admet-155	151	13	(	(	PUNCT
admet-155	151	14	1975	1975	NUM
admet-155	151	15	)	)	PUNCT
admet-155	151	16	190–195	190–195	NUM
admet-155	151	17	.	.	PUNCT
admet-155	152	1	[	[	X
admet-155	152	2	33	33	NUM
admet-155	152	3	]	]	X
admet-155	152	4	u.	u.	PROPN
admet-155	152	5	jacobi	jacobi	PROPN
admet-155	152	6	,	,	PUNCT
admet-155	152	7	m.	m.	PROPN
admet-155	152	8	kaiser	kaiser	PROPN
admet-155	152	9	,	,	PUNCT
admet-155	152	10	r.	r.	PROPN
admet-155	152	11	toll	toll	PROPN
admet-155	152	12	,	,	PUNCT
admet-155	152	13	s.	s.	PROPN
admet-155	152	14	mangelsdorf	mangelsdorf	PROPN
admet-155	152	15	,	,	PUNCT
admet-155	152	16	h.	h.	PROPN
admet-155	152	17	audring	audring	PROPN
admet-155	152	18	,	,	PUNCT
admet-155	152	19	n.	n.	PROPN
admet-155	152	20	otberg	otberg	PROPN
admet-155	152	21	,	,	PUNCT
admet-155	152	22	w.	w.	PROPN
admet-155	152	23	sterry	sterry	PROPN
admet-155	152	24	,	,	PUNCT
admet-155	152	25	j.	j.	PROPN
admet-155	152	26	lademann	lademann	PROPN
admet-155	152	27	,	,	PUNCT
admet-155	152	28	skin	skin	NOUN
admet-155	152	29	research	research	NOUN
admet-155	152	30	and	and	CCONJ
admet-155	152	31	technology	technology	NOUN
admet-155	152	32	13	13	NUM
admet-155	152	33	(	(	PUNCT
admet-155	152	34	2007	2007	NUM
admet-155	152	35	)	)	PUNCT
admet-155	152	36	19–24	19–24	NUM
admet-155	152	37	.	.	PUNCT
admet-155	153	1	[	[	X
admet-155	153	2	34	34	NUM
admet-155	153	3	]	]	SYM
admet-155	153	4	c.m	c.m	AUX
admet-155	153	5	.	.	PROPN
admet-155	153	6	heard	heard	PROPN
admet-155	153	7	,	,	PUNCT
admet-155	153	8	k.r	k.r	PROPN
admet-155	153	9	.	.	PROPN
admet-155	153	10	brain	brain	PROPN
admet-155	153	11	,	,	PUNCT
admet-155	153	12	chirality	chirality	NOUN
admet-155	153	13	7	7	NUM
admet-155	153	14	(	(	PUNCT
admet-155	153	15	1995	1995	NUM
admet-155	153	16	)	)	PUNCT
admet-155	153	17	305–309	305–309	NUM
admet-155	153	18	.	.	PUNCT
admet-155	154	1	[	[	X
admet-155	154	2	35	35	NUM
admet-155	154	3	]	]	X
admet-155	154	4	j.	j.	PROPN
admet-155	154	5	valentova	valentova	PROPN
admet-155	154	6	,	,	PUNCT
admet-155	154	7	k.	k.	PROPN
admet-155	154	8	bauerova	bauerova	PROPN
admet-155	154	9	,	,	PUNCT
admet-155	154	10	l.	l.	PROPN
admet-155	154	11	farah	farah	PROPN
admet-155	154	12	,	,	PUNCT
admet-155	154	13	f.	f.	PROPN
admet-155	154	14	devinsky	devinsky	PROPN
admet-155	154	15	,	,	PUNCT
admet-155	154	16	archives	archive	NOUN
admet-155	154	17	of	of	ADP
admet-155	154	18	dermatological	dermatological	ADJ
admet-155	154	19	research	research	NOUN
admet-155	154	20	302	302	NUM
admet-155	154	21	(	(	PUNCT
admet-155	154	22	2010	2010	NUM
admet-155	154	23	)	)	PUNCT
admet-155	154	24	635	635	NUM
admet-155	154	25	-	-	PUNCT
admet-155	154	26	638	638	NUM
admet-155	154	27	.	.	PUNCT
admet-155	155	1	[	[	X
admet-155	155	2	36	36	NUM
admet-155	155	3	]	]	PUNCT
admet-155	155	4	a.	a.	NOUN
admet-155	155	5	zeng	zeng	PROPN
admet-155	155	6	,	,	PUNCT
admet-155	155	7	c.	c.	PROPN
admet-155	155	8	wang	wang	PROPN
admet-155	155	9	,	,	PUNCT
admet-155	155	10	b.	b.	PROPN
admet-155	155	11	yuan	yuan	PROPN
admet-155	155	12	,	,	PUNCT
admet-155	155	13	g.	g.	PROPN
admet-155	155	14	yang	yang	PROPN
admet-155	155	15	,	,	PUNCT
admet-155	155	16	q.	q.	PROPN
admet-155	155	17	fu	fu	PROPN
admet-155	155	18	,	,	PUNCT
admet-155	155	19	drug	drug	NOUN
admet-155	155	20	development	development	NOUN
admet-155	155	21	and	and	CCONJ
admet-155	155	22	industrial	industrial	ADJ
admet-155	155	23	pharmacy	pharmacy	NOUN
admet-155	155	24	36	36	NUM
admet-155	155	25	(	(	PUNCT
admet-155	155	26	2010	2010	NUM
admet-155	155	27	)	)	PUNCT
admet-155	155	28	724–734	724–734	NUM
admet-155	155	29	.	.	PUNCT
admet-155	156	1	[	[	X
admet-155	156	2	37	37	NUM
admet-155	156	3	]	]	X
admet-155	156	4	j.	j.	PROPN
admet-155	156	5	novotny	novotny	PROPN
admet-155	156	6	,	,	PUNCT
admet-155	156	7	p.	p.	PROPN
admet-155	156	8	kovarikova	kovarikova	PROPN
admet-155	156	9	,	,	PUNCT
admet-155	156	10	m.	m.	PROPN
admet-155	156	11	novotny	novotny	PROPN
admet-155	156	12	,	,	PUNCT
admet-155	156	13	b.	b.	PROPN
admet-155	156	14	janusova	janusova	PROPN
admet-155	156	15	,	,	PUNCT
admet-155	156	16	a.	a.	PROPN
admet-155	156	17	hrabalek	hrabalek	PROPN
admet-155	156	18	,	,	PUNCT
admet-155	156	19	k.	k.	PROPN
admet-155	156	20	vavrova	vavrova	PROPN
admet-155	156	21	,	,	PUNCT
admet-155	156	22	pharmaceutical	pharmaceutical	ADJ
admet-155	156	23	research	research	NOUN
admet-155	156	24	26	26	NUM
admet-155	156	25	(	(	PUNCT
admet-155	156	26	2009	2009	NUM
admet-155	156	27	)	)	PUNCT
admet-155	156	28	811–821	811–821	NUM
admet-155	156	29	.	.	PUNCT
admet-155	157	1	[	[	X
admet-155	157	2	38	38	NUM
admet-155	157	3	]	]	SYM
admet-155	157	4	y.s.r	y.s.r	PROPN
admet-155	157	5	.	.	PROPN
admet-155	157	6	krishnaiah	krishnaiah	PROPN
admet-155	157	7	,	,	PUNCT
admet-155	157	8	a.	a.	PROPN
admet-155	157	9	nada	nada	PROPN
admet-155	157	10	,	,	PUNCT
admet-155	157	11	pharmaceutical	pharmaceutical	NOUN
admet-155	157	12	development	development	NOUN
admet-155	157	13	and	and	CCONJ
admet-155	157	14	technology	technology	NOUN
admet-155	157	15	17	17	NUM
admet-155	157	16	(	(	PUNCT
admet-155	157	17	2011	2011	NUM
admet-155	157	18	)	)	PUNCT
admet-155	157	19	574–582	574–582	NUM
admet-155	157	20	.	.	PUNCT
admet-155	158	1	©	©	PROPN
admet-155	158	2	2014	2014	NUM
admet-155	158	3	by	by	ADP
admet-155	158	4	the	the	DET
admet-155	158	5	authors	author	NOUN
admet-155	158	6	;	;	PUNCT
admet-155	158	7	licensee	licensee	PROPN
admet-155	158	8	iapc	iapc	PROPN
admet-155	158	9	,	,	PUNCT
admet-155	158	10	zagreb	zagreb	PROPN
admet-155	158	11	,	,	PUNCT
admet-155	158	12	croatia	croatia	PROPN
admet-155	158	13	.	.	PUNCT
admet-155	159	1	this	this	DET
admet-155	159	2	article	article	NOUN
admet-155	159	3	is	be	AUX
admet-155	159	4	an	an	DET
admet-155	159	5	open	open	ADJ
admet-155	159	6	-	-	PUNCT
admet-155	159	7	access	access	NOUN
admet-155	159	8	article	article	NOUN
admet-155	159	9	distributed	distribute	VERB
admet-155	159	10	under	under	ADP
admet-155	159	11	the	the	DET
admet-155	159	12	terms	term	NOUN
admet-155	159	13	and	and	CCONJ
admet-155	159	14	conditions	condition	NOUN
admet-155	159	15	of	of	ADP
admet-155	159	16	the	the	DET
admet-155	159	17	creative	creative	ADJ
admet-155	159	18	commons	common	NOUN
admet-155	159	19	attribution	attribution	NOUN
admet-155	159	20	license	license	NOUN
admet-155	159	21	(	(	PUNCT
admet-155	159	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN
admet-155	159	23	)	)	PUNCT
admet-155	159	24	http://www.drugbank.ca/drugs/db01698	http://www.drugbank.ca/drugs/db01698	NOUN
admet-155	159	25	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN