id	sid	tid	token	lemma	pos
admet-1570	1	1	development	development	NOUN
admet-1570	1	2	and	and	CCONJ
admet-1570	1	3	application	application	NOUN
admet-1570	1	4	of	of	ADP
admet-1570	1	5	a	a	DET
admet-1570	1	6	simple	simple	ADJ
admet-1570	1	7	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	1	8	model	model	NOUN
admet-1570	1	9	that	that	PRON
admet-1570	1	10	quantitatively	quantitatively	ADV
admet-1570	1	11	describes	describe	VERB
admet-1570	1	12	the	the	DET
admet-1570	1	13	distribution	distribution	NOUN
admet-1570	1	14	and	and	CCONJ
admet-1570	1	15	elimination	elimination	NOUN
admet-1570	1	16	of	of	ADP
admet-1570	1	17	the	the	DET
admet-1570	1	18	commonly	commonly	ADV
admet-1570	1	19	measured	measure	VERB
admet-1570	1	20	proteins	protein	NOUN
admet-1570	1	21	doi	doi	NOUN
admet-1570	1	22	:	:	PUNCT
admet-1570	1	23	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	1	24	57	57	NUM
admet-1570	1	25	admet	admet	X
admet-1570	1	26	&	&	CCONJ
admet-1570	1	27	dmpk	dmpk	PROPN
admet-1570	1	28	11(1	11(1	NUM
admet-1570	1	29	)	)	PUNCT
admet-1570	1	30	(	(	PUNCT
admet-1570	1	31	2023	2023	NUM
admet-1570	1	32	)	)	PUNCT
admet-1570	1	33	57	57	NUM
admet-1570	1	34	-	-	SYM
admet-1570	1	35	80	80	NUM
admet-1570	1	36	;	;	PUNCT
admet-1570	1	37	doi	doi	NOUN
admet-1570	1	38	:	:	PUNCT
admet-1570	1	39	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	1	40	open	open	ADJ
admet-1570	1	41	access	access	NOUN
admet-1570	1	42	:	:	PUNCT
admet-1570	1	43	issn	issn	PROPN
admet-1570	1	44	:	:	PUNCT
admet-1570	1	45	1848	1848	NUM
admet-1570	1	46	-	-	SYM
admet-1570	1	47	7718	7718	NUM
admet-1570	1	48	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1570	1	49	original	original	ADJ
admet-1570	1	50	scientific	scientific	ADJ
admet-1570	1	51	paper	paper	NOUN
admet-1570	1	52	development	development	NOUN
admet-1570	1	53	and	and	CCONJ
admet-1570	1	54	application	application	NOUN
admet-1570	1	55	of	of	ADP
admet-1570	1	56	a	a	DET
admet-1570	1	57	simple	simple	ADJ
admet-1570	1	58	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	1	59	model	model	NOUN
admet-1570	1	60	that	that	PRON
admet-1570	1	61	quantitatively	quantitatively	ADV
admet-1570	1	62	describes	describe	VERB
admet-1570	1	63	the	the	DET
admet-1570	1	64	distribution	distribution	NOUN
admet-1570	1	65	and	and	CCONJ
admet-1570	1	66	elimination	elimination	NOUN
admet-1570	1	67	of	of	ADP
admet-1570	1	68	the	the	DET
admet-1570	1	69	commonly	commonly	ADV
admet-1570	1	70	measured	measure	VERB
admet-1570	1	71	proteins	protein	NOUN
admet-1570	1	72	david	david	PROPN
admet-1570	1	73	g.	g.	PROPN
admet-1570	1	74	levitt,1	levitt,1	PROPN
admet-1570	1	75	*	*	VERB
admet-1570	1	76	michael	michael	PROPN
admet-1570	1	77	d.	d.	PROPN
admet-1570	1	78	levitt2	levitt2	PROPN
admet-1570	1	79	1	1	NUM
admet-1570	1	80	department	department	NOUN
admet-1570	1	81	of	of	ADP
admet-1570	1	82	integrative	integrative	ADJ
admet-1570	1	83	biology	biology	NOUN
admet-1570	1	84	and	and	CCONJ
admet-1570	1	85	physiology	physiology	NOUN
admet-1570	1	86	,	,	PUNCT
admet-1570	1	87	university	university	NOUN
admet-1570	1	88	of	of	ADP
admet-1570	1	89	minnesota	minnesota	PROPN
admet-1570	1	90	,	,	PUNCT
admet-1570	1	91	minneapolis	minneapolis	PROPN
admet-1570	1	92	,	,	PUNCT
admet-1570	1	93	mn	mn	PROPN
admet-1570	1	94	55455	55455	NUM
admet-1570	1	95	,	,	PUNCT
admet-1570	1	96	usa	usa	PROPN
admet-1570	1	97	;	;	PUNCT
admet-1570	1	98	levit001@umn.edu	levit001@umn.edu	PROPN
admet-1570	1	99	2	2	NUM
admet-1570	1	100	medicine	medicine	NOUN
admet-1570	1	101	service	service	NOUN
admet-1570	1	102	,	,	PUNCT
admet-1570	1	103	veterans	veterans	PROPN
admet-1570	1	104	affairs	affairs	PROPN
admet-1570	1	105	medical	medical	ADJ
admet-1570	1	106	center	center	NOUN
admet-1570	1	107	,	,	PUNCT
admet-1570	1	108	minneapolis	minneapolis	PROPN
admet-1570	1	109	,	,	PUNCT
admet-1570	1	110	mn	mn	PROPN
admet-1570	1	111	.	.	PROPN
admet-1570	1	112	55417	55417	NUM
admet-1570	1	113	,	,	PUNCT
admet-1570	1	114	usa	usa	PROPN
admet-1570	1	115	;	;	PUNCT
admet-1570	1	116	michael.levitt@va.gov	michael.levitt@va.gov	PROPN
admet-1570	1	117	*	*	PUNCT
admet-1570	1	118	corresponding	correspond	VERB
admet-1570	1	119	author	author	NOUN
admet-1570	1	120	:	:	PUNCT
admet-1570	1	121	e	e	NOUN
admet-1570	1	122	-	-	NOUN
admet-1570	1	123	mail	mail	NOUN
admet-1570	1	124	:	:	PUNCT
admet-1570	2	1	levit001@umn.edu	levit001@umn.edu	PROPN
admet-1570	2	2	received	receive	VERB
admet-1570	2	3	:	:	PUNCT
admet-1570	2	4	october	october	PROPN
admet-1570	2	5	25	25	NUM
admet-1570	2	6	,	,	PUNCT
admet-1570	2	7	2022	2022	NUM
admet-1570	2	8	;	;	PUNCT
admet-1570	2	9	revised	revise	VERB
admet-1570	2	10	:	:	PUNCT
admet-1570	2	11	january	january	PROPN
admet-1570	2	12	22	22	NUM
admet-1570	2	13	,	,	PUNCT
admet-1570	2	14	2023	2023	NUM
admet-1570	2	15	;	;	PUNCT
admet-1570	2	16	published	publish	VERB
admet-1570	2	17	:	:	PUNCT
admet-1570	2	18	january	january	PROPN
admet-1570	2	19	26	26	NUM
admet-1570	2	20	,	,	PUNCT
admet-1570	2	21	2023	2023	NUM
admet-1570	2	22	abstract	abstract	ADJ
admet-1570	2	23	increased	increase	VERB
admet-1570	2	24	plasma	plasma	NOUN
admet-1570	2	25	concentrations	concentration	NOUN
admet-1570	2	26	of	of	ADP
admet-1570	2	27	a	a	DET
admet-1570	2	28	variety	variety	NOUN
admet-1570	2	29	of	of	ADP
admet-1570	2	30	cellular	cellular	ADJ
admet-1570	2	31	enzymes	enzyme	NOUN
admet-1570	2	32	(	(	PUNCT
admet-1570	2	33	alanine	alanine	NOUN
admet-1570	2	34	transaminase	transaminase	NOUN
admet-1570	2	35	,	,	PUNCT
admet-1570	2	36	aspartate	aspartate	NOUN
admet-1570	2	37	aminotransferase	aminotransferase	NOUN
admet-1570	2	38	,	,	PUNCT
admet-1570	2	39	alkaline	alkaline	NOUN
admet-1570	2	40	phosphatase	phosphatase	NOUN
admet-1570	2	41	,	,	PUNCT
admet-1570	2	42	amylase	amylase	NOUN
admet-1570	2	43	,	,	PUNCT
admet-1570	2	44	etc	etc	X
admet-1570	2	45	.	.	X
admet-1570	2	46	)	)	PUNCT
admet-1570	2	47	are	be	AUX
admet-1570	2	48	commonly	commonly	ADV
admet-1570	2	49	used	use	VERB
admet-1570	2	50	as	as	ADP
admet-1570	2	51	routine	routine	ADJ
admet-1570	2	52	screening	screening	NOUN
admet-1570	2	53	tests	test	NOUN
admet-1570	2	54	for	for	ADP
admet-1570	2	55	a	a	DET
admet-1570	2	56	range	range	NOUN
admet-1570	2	57	of	of	ADP
admet-1570	2	58	conditions	condition	NOUN
admet-1570	2	59	.	.	PUNCT
admet-1570	3	1	an	an	DET
admet-1570	3	2	increased	increase	VERB
admet-1570	3	3	concentration	concentration	NOUN
admet-1570	3	4	usually	usually	ADV
admet-1570	3	5	is	be	AUX
admet-1570	3	6	assumed	assume	VERB
admet-1570	3	7	to	to	PART
admet-1570	3	8	result	result	VERB
admet-1570	3	9	from	from	ADP
admet-1570	3	10	an	an	DET
admet-1570	3	11	increased	increase	VERB
admet-1570	3	12	rate	rate	NOUN
admet-1570	3	13	of	of	ADP
admet-1570	3	14	delivery	delivery	NOUN
admet-1570	3	15	to	to	ADP
admet-1570	3	16	the	the	DET
admet-1570	3	17	plasma	plasma	NOUN
admet-1570	3	18	.	.	PUNCT
admet-1570	4	1	factors	factor	NOUN
admet-1570	4	2	such	such	ADJ
admet-1570	4	3	as	as	ADP
admet-1570	4	4	decreased	decrease	VERB
admet-1570	4	5	metabolism	metabolism	NOUN
admet-1570	4	6	or	or	CCONJ
admet-1570	4	7	excretion	excretion	NOUN
admet-1570	4	8	or	or	CCONJ
admet-1570	4	9	altered	alter	VERB
admet-1570	4	10	extravascular	extravascular	ADJ
admet-1570	4	11	distribution	distribution	NOUN
admet-1570	4	12	usually	usually	ADV
admet-1570	4	13	are	be	AUX
admet-1570	4	14	ignored	ignore	VERB
admet-1570	4	15	.	.	PUNCT
admet-1570	5	1	as	as	ADP
admet-1570	5	2	a	a	DET
admet-1570	5	3	prelude	prelude	NOUN
admet-1570	5	4	to	to	ADP
admet-1570	5	5	a	a	DET
admet-1570	5	6	detailed	detailed	ADJ
admet-1570	5	7	analysis	analysis	NOUN
admet-1570	5	8	of	of	ADP
admet-1570	5	9	all	all	DET
admet-1570	5	10	the	the	DET
admet-1570	5	11	factors	factor	NOUN
admet-1570	5	12	producing	produce	VERB
admet-1570	5	13	altered	alter	VERB
admet-1570	5	14	plasma	plasma	NOUN
admet-1570	5	15	enzyme	enzyme	NOUN
admet-1570	5	16	levels	level	NOUN
admet-1570	5	17	,	,	PUNCT
admet-1570	5	18	we	we	PRON
admet-1570	5	19	have	have	AUX
admet-1570	5	20	reviewed	review	VERB
admet-1570	5	21	the	the	DET
admet-1570	5	22	relevant	relevant	ADJ
admet-1570	5	23	literature	literature	NOUN
admet-1570	5	24	describing	describe	VERB
admet-1570	5	25	the	the	DET
admet-1570	5	26	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	5	27	(	(	PUNCT
admet-1570	5	28	pk	pk	NOUN
admet-1570	5	29	)	)	PUNCT
admet-1570	5	30	of	of	ADP
admet-1570	5	31	13	13	NUM
admet-1570	5	32	of	of	ADP
admet-1570	5	33	the	the	DET
admet-1570	5	34	commonly	commonly	ADV
admet-1570	5	35	measured	measure	VERB
admet-1570	5	36	plasma	plasma	NOUN
admet-1570	5	37	proteins	protein	NOUN
admet-1570	5	38	and	and	CCONJ
admet-1570	5	39	developed	develop	VERB
admet-1570	5	40	a	a	DET
admet-1570	5	41	pk	pk	NOUN
admet-1570	5	42	model	model	NOUN
admet-1570	5	43	that	that	PRON
admet-1570	5	44	provides	provide	VERB
admet-1570	5	45	a	a	DET
admet-1570	5	46	simple	simple	ADJ
admet-1570	5	47	physiological	physiological	ADJ
admet-1570	5	48	description	description	NOUN
admet-1570	5	49	of	of	ADP
admet-1570	5	50	all	all	DET
admet-1570	5	51	the	the	DET
admet-1570	5	52	data	datum	NOUN
admet-1570	5	53	.	.	PUNCT
admet-1570	6	1	our	our	PRON
admet-1570	6	2	model	model	NOUN
admet-1570	6	3	starts	start	VERB
admet-1570	6	4	with	with	ADP
admet-1570	6	5	the	the	DET
admet-1570	6	6	general	general	ADJ
admet-1570	6	7	3	3	NUM
admet-1570	6	8	-	-	PUNCT
admet-1570	6	9	compartment	compartment	NOUN
admet-1570	6	10	,	,	PUNCT
admet-1570	6	11	6	6	NUM
admet-1570	6	12	-	-	PUNCT
admet-1570	6	13	parameter	parameter	NOUN
admet-1570	6	14	system	system	NOUN
admet-1570	6	15	previously	previously	ADV
admet-1570	6	16	developed	develop	VERB
admet-1570	6	17	for	for	ADP
admet-1570	6	18	albumin	albumin	NOUN
admet-1570	6	19	and	and	CCONJ
admet-1570	6	20	interprets	interpret	VERB
admet-1570	6	21	the	the	DET
admet-1570	6	22	fluxes	flux	NOUN
admet-1570	6	23	in	in	ADP
admet-1570	6	24	terms	term	NOUN
admet-1570	6	25	of	of	ADP
admet-1570	6	26	unidirectional	unidirectional	ADJ
admet-1570	6	27	sieved	sieve	VERB
admet-1570	6	28	protein	protein	NOUN
admet-1570	6	29	convectional	convectional	ADJ
admet-1570	6	30	volume	volume	NOUN
admet-1570	6	31	flows	flow	VERB
admet-1570	6	32	from	from	ADP
admet-1570	6	33	the	the	DET
admet-1570	6	34	plasma	plasma	NOUN
admet-1570	6	35	to	to	ADP
admet-1570	6	36	the	the	DET
admet-1570	6	37	two	two	NUM
admet-1570	6	38	tissue	tissue	NOUN
admet-1570	6	39	compartments	compartment	NOUN
admet-1570	6	40	and	and	CCONJ
admet-1570	6	41	equal	equal	ADJ
admet-1570	6	42	lymph	lymph	NOUN
admet-1570	6	43	flows	flow	NOUN
admet-1570	6	44	returning	return	VERB
admet-1570	6	45	to	to	ADP
admet-1570	6	46	the	the	DET
admet-1570	6	47	plasma	plasma	NOUN
admet-1570	6	48	.	.	PUNCT
admet-1570	7	1	this	this	PRON
admet-1570	7	2	greatly	greatly	ADV
admet-1570	7	3	constrains	constrain	VERB
admet-1570	7	4	the	the	DET
admet-1570	7	5	model	model	NOUN
admet-1570	7	6	such	such	ADJ
admet-1570	7	7	that	that	SCONJ
admet-1570	7	8	each	each	DET
admet-1570	7	9	protein	protein	NOUN
admet-1570	7	10	is	be	AUX
admet-1570	7	11	characterized	characterize	VERB
admet-1570	7	12	by	by	ADP
admet-1570	7	13	only	only	ADV
admet-1570	7	14	two	two	NUM
admet-1570	7	15	adjustable	adjustable	ADJ
admet-1570	7	16	parameters	parameter	NOUN
admet-1570	7	17	(	(	PUNCT
admet-1570	7	18	plasma	plasma	NOUN
admet-1570	7	19	clearance	clearance	NOUN
admet-1570	7	20	and	and	CCONJ
admet-1570	7	21	sieving	sieve	VERB
admet-1570	7	22	factor	factor	NOUN
admet-1570	7	23	)	)	PUNCT
admet-1570	7	24	.	.	PUNCT
admet-1570	8	1	in	in	ADP
admet-1570	8	2	addition	addition	NOUN
admet-1570	8	3	to	to	ADP
admet-1570	8	4	accurately	accurately	ADV
admet-1570	8	5	fitting	fit	VERB
admet-1570	8	6	the	the	DET
admet-1570	8	7	plasma	plasma	NOUN
admet-1570	8	8	kinetics	kinetic	NOUN
admet-1570	8	9	,	,	PUNCT
admet-1570	8	10	the	the	DET
admet-1570	8	11	model	model	NOUN
admet-1570	8	12	can	can	AUX
admet-1570	8	13	accurately	accurately	ADV
admet-1570	8	14	describe	describe	VERB
admet-1570	8	15	the	the	DET
admet-1570	8	16	tissue	tissue	NOUN
admet-1570	8	17	and	and	CCONJ
admet-1570	8	18	lymph	lymph	NOUN
admet-1570	8	19	protein	protein	NOUN
admet-1570	8	20	pk	pk	NOUN
admet-1570	8	21	.	.	PROPN
admet-1570	8	22	for	for	ADP
admet-1570	8	23	example	example	NOUN
admet-1570	8	24	,	,	PUNCT
admet-1570	8	25	it	it	PRON
admet-1570	8	26	can	can	AUX
admet-1570	8	27	describe	describe	VERB
admet-1570	8	28	the	the	DET
admet-1570	8	29	thoracic	thoracic	NOUN
admet-1570	8	30	duct	duct	NOUN
admet-1570	8	31	lymph	lymph	NOUN
admet-1570	8	32	protein	protein	NOUN
admet-1570	8	33	concentration	concentration	NOUN
admet-1570	8	34	following	follow	VERB
admet-1570	8	35	an	an	DET
admet-1570	8	36	intravenous	intravenous	ADJ
admet-1570	8	37	infusion	infusion	NOUN
admet-1570	8	38	or	or	CCONJ
admet-1570	8	39	the	the	DET
admet-1570	8	40	plasma	plasma	NOUN
admet-1570	8	41	concentration	concentration	NOUN
admet-1570	8	42	following	follow	VERB
admet-1570	8	43	a	a	DET
admet-1570	8	44	subcutaneous	subcutaneous	ADJ
admet-1570	8	45	tissue	tissue	NOUN
admet-1570	8	46	injection	injection	NOUN
admet-1570	8	47	.	.	PUNCT
admet-1570	9	1	this	this	DET
admet-1570	9	2	simple	simple	ADJ
admet-1570	9	3	model	model	NOUN
admet-1570	9	4	provides	provide	VERB
admet-1570	9	5	a	a	DET
admet-1570	9	6	satisfactory	satisfactory	ADJ
admet-1570	9	7	framework	framework	NOUN
admet-1570	9	8	for	for	ADP
admet-1570	9	9	the	the	DET
admet-1570	9	10	pk	pk	NOUN
admet-1570	9	11	of	of	ADP
admet-1570	9	12	12	12	NUM
admet-1570	9	13	of	of	ADP
admet-1570	9	14	the	the	DET
admet-1570	9	15	13	13	NUM
admet-1570	9	16	proteins	protein	NOUN
admet-1570	9	17	investigated	investigate	VERB
admet-1570	9	18	.	.	PUNCT
admet-1570	10	1	the	the	DET
admet-1570	10	2	glycoprotein	glycoprotein	ADJ
admet-1570	10	3	intestinal	intestinal	ADJ
admet-1570	10	4	alkaline	alkaline	NOUN
admet-1570	10	5	phosphatase	phosphatase	NOUN
admet-1570	10	6	is	be	AUX
admet-1570	10	7	the	the	DET
admet-1570	10	8	exception	exception	NOUN
admet-1570	10	9	,	,	PUNCT
admet-1570	10	10	requiring	require	VERB
admet-1570	10	11	the	the	DET
admet-1570	10	12	addition	addition	NOUN
admet-1570	10	13	of	of	ADP
admet-1570	10	14	a	a	DET
admet-1570	10	15	liver	liver	NOUN
admet-1570	10	16	recycling	recycling	NOUN
admet-1570	10	17	compartment	compartment	NOUN
admet-1570	10	18	involving	involve	VERB
admet-1570	10	19	the	the	DET
admet-1570	10	20	asialoglycoprotein	asialoglycoprotein	ADJ
admet-1570	10	21	receptor	receptor	NOUN
admet-1570	10	22	.	.	PUNCT
admet-1570	11	1	©	©	PROPN
admet-1570	11	2	2023	2023	NUM
admet-1570	11	3	by	by	ADP
admet-1570	11	4	the	the	DET
admet-1570	11	5	authors	author	NOUN
admet-1570	11	6	.	.	PUNCT
admet-1570	12	1	this	this	DET
admet-1570	12	2	article	article	NOUN
admet-1570	12	3	is	be	AUX
admet-1570	12	4	an	an	DET
admet-1570	12	5	open	open	ADJ
admet-1570	12	6	-	-	PUNCT
admet-1570	12	7	access	access	NOUN
admet-1570	12	8	article	article	NOUN
admet-1570	12	9	distributed	distribute	VERB
admet-1570	12	10	under	under	ADP
admet-1570	12	11	the	the	DET
admet-1570	12	12	terms	term	NOUN
admet-1570	12	13	and	and	CCONJ
admet-1570	12	14	conditions	condition	NOUN
admet-1570	12	15	of	of	ADP
admet-1570	12	16	the	the	DET
admet-1570	12	17	creative	creative	ADJ
admet-1570	12	18	commons	common	NOUN
admet-1570	12	19	attribution	attribution	NOUN
admet-1570	12	20	license	license	NOUN
admet-1570	12	21	(	(	PUNCT
admet-1570	12	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1570	12	23	)	)	PUNCT
admet-1570	12	24	.	.	PUNCT
admet-1570	13	1	keywords	keyword	VERB
admet-1570	13	2	protein	protein	NOUN
admet-1570	13	3	;	;	PUNCT
admet-1570	13	4	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	13	5	;	;	PUNCT
admet-1570	13	6	alkaline	alkaline	NOUN
admet-1570	13	7	phosphatase	phosphatase	NOUN
admet-1570	13	8	;	;	PUNCT
admet-1570	13	9	alanine	alanine	NOUN
admet-1570	13	10	transaminase	transaminase	NOUN
admet-1570	13	11	;	;	PUNCT
admet-1570	13	12	aspartate	aspartate	NOUN
admet-1570	13	13	aminotransferase	aminotransferase	NOUN
admet-1570	13	14	;	;	PUNCT
admet-1570	13	15	amylase	amylase	NOUN
admet-1570	13	16	;	;	PUNCT
admet-1570	13	17	albumin	albumin	NOUN
admet-1570	13	18	;	;	PUNCT
admet-1570	13	19	liver	liver	NOUN
admet-1570	13	20	;	;	PUNCT
admet-1570	13	21	pancreas	pancrea	NOUN
admet-1570	13	22	introduction	introduction	NOUN
admet-1570	13	23	the	the	DET
admet-1570	13	24	standard	standard	ADJ
admet-1570	13	25	approach	approach	NOUN
admet-1570	13	26	to	to	ADP
admet-1570	13	27	characterizing	characterize	VERB
admet-1570	13	28	protein	protein	NOUN
admet-1570	13	29	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	13	30	(	(	PUNCT
admet-1570	13	31	pk	pk	NOUN
admet-1570	13	32	)	)	PUNCT
admet-1570	13	33	is	be	AUX
admet-1570	13	34	via	via	ADP
admet-1570	13	35	the	the	DET
admet-1570	13	36	classical	classical	ADJ
admet-1570	13	37	2	2	NUM
admet-1570	13	38	-	-	PUNCT
admet-1570	13	39	compartment	compartment	NOUN
admet-1570	13	40	(	(	PUNCT
admet-1570	13	41	4	4	NUM
admet-1570	13	42	parameters	parameter	NOUN
admet-1570	13	43	)	)	PUNCT
admet-1570	14	1	[	[	X
admet-1570	14	2	1,2	1,2	NUM
admet-1570	14	3	]	]	PUNCT
admet-1570	14	4	or	or	CCONJ
admet-1570	14	5	3	3	NUM
admet-1570	14	6	-	-	PUNCT
admet-1570	14	7	compartment	compartment	NOUN
admet-1570	14	8	(	(	PUNCT
admet-1570	14	9	6	6	NUM
admet-1570	14	10	parameters	parameter	NOUN
admet-1570	14	11	)	)	PUNCT
admet-1570	15	1	[	[	X
admet-1570	15	2	3,4	3,4	NUM
admet-1570	15	3	]	]	PUNCT
admet-1570	15	4	modeling	modeling	NOUN
admet-1570	15	5	.	.	PUNCT
admet-1570	16	1	for	for	ADP
admet-1570	16	2	most	most	ADJ
admet-1570	16	3	clinical	clinical	ADJ
admet-1570	16	4	purposes	purpose	NOUN
admet-1570	16	5	,	,	PUNCT
admet-1570	16	6	2	2	NUM
admet-1570	16	7	compartments	compartment	NOUN
admet-1570	16	8	are	be	AUX
admet-1570	16	9	sufficient	sufficient	ADJ
admet-1570	16	10	[	[	X
admet-1570	16	11	1,2	1,2	NUM
admet-1570	16	12	]	]	PUNCT
admet-1570	16	13	.	.	PUNCT
admet-1570	17	1	however	however	ADV
admet-1570	17	2	,	,	PUNCT
admet-1570	17	3	in	in	ADP
admet-1570	17	4	order	order	NOUN
admet-1570	17	5	to	to	PART
admet-1570	17	6	accurately	accurately	ADV
admet-1570	17	7	fit	fit	VERB
admet-1570	17	8	the	the	DET
admet-1570	17	9	details	detail	NOUN
admet-1570	17	10	of	of	ADP
admet-1570	17	11	the	the	DET
admet-1570	17	12	plasma	plasma	NOUN
admet-1570	17	13	concentration	concentration	NOUN
admet-1570	17	14	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	17	15	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	17	16	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1570	17	17	mailto:levit001@umn.edu	mailto:levit001@umn.edu	NOUN
admet-1570	17	18	mailto:michael.levitt@va.gov	mailto:michael.levitt@va.gov	NOUN
admet-1570	17	19	mailto:levit001@umn.edu	mailto:levit001@umn.edu	VERB
admet-1570	17	20	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1570	17	21	d.g	d.g	PROPN
admet-1570	17	22	.	.	PROPN
admet-1570	17	23	levitt	levitt	PROPN
admet-1570	17	24	and	and	CCONJ
admet-1570	17	25	m.d	m.d	PROPN
admet-1570	17	26	.	.	PROPN
admet-1570	17	27	levitt	levitt	PROPN
admet-1570	17	28	admet	admet	PROPN
admet-1570	17	29	&	&	CCONJ
admet-1570	17	30	dmpk	dmpk	PROPN
admet-1570	17	31	11(1	11(1	NUM
admet-1570	17	32	)	)	PUNCT
admet-1570	17	33	(	(	PUNCT
admet-1570	17	34	2023	2023	NUM
admet-1570	17	35	)	)	PUNCT
admet-1570	17	36	57	57	NUM
admet-1570	17	37	-	-	SYM
admet-1570	17	38	80	80	NUM
admet-1570	17	39	58	58	NUM
admet-1570	17	40	curve	curve	NOUN
admet-1570	17	41	,	,	PUNCT
admet-1570	17	42	usually	usually	ADV
admet-1570	17	43	3	3	NUM
admet-1570	17	44	compartments	compartment	NOUN
admet-1570	17	45	are	be	AUX
admet-1570	17	46	required	require	VERB
admet-1570	17	47	[	[	PUNCT
admet-1570	17	48	3,4	3,4	NUM
admet-1570	17	49	]	]	PUNCT
admet-1570	17	50	.	.	PUNCT
admet-1570	18	1	each	each	DET
admet-1570	18	2	protein	protein	NOUN
admet-1570	18	3	is	be	AUX
admet-1570	18	4	characterized	characterize	VERB
admet-1570	18	5	by	by	ADP
admet-1570	18	6	a	a	DET
admet-1570	18	7	six	six	NUM
admet-1570	18	8	-	-	PUNCT
admet-1570	18	9	parameter	parameter	NOUN
admet-1570	18	10	set	set	NOUN
admet-1570	18	11	determined	determine	VERB
admet-1570	18	12	by	by	ADP
admet-1570	18	13	fitting	fit	VERB
admet-1570	18	14	the	the	DET
admet-1570	18	15	model	model	NOUN
admet-1570	18	16	to	to	ADP
admet-1570	18	17	the	the	DET
admet-1570	18	18	plasma	plasma	NOUN
admet-1570	18	19	protein	protein	NOUN
admet-1570	18	20	concentration	concentration	NOUN
admet-1570	18	21	following	follow	VERB
admet-1570	18	22	bolus	bolus	ADJ
admet-1570	18	23	injection	injection	NOUN
admet-1570	18	24	.	.	PUNCT
admet-1570	19	1	the	the	DET
admet-1570	19	2	recent	recent	ADJ
admet-1570	19	3	proliferation	proliferation	NOUN
admet-1570	19	4	of	of	ADP
admet-1570	19	5	therapeutic	therapeutic	ADJ
admet-1570	19	6	proteins	protein	NOUN
admet-1570	19	7	,	,	PUNCT
admet-1570	19	8	especially	especially	ADV
admet-1570	19	9	monoclonal	monoclonal	NOUN
admet-1570	19	10	antibodies	antibody	NOUN
admet-1570	19	11	,	,	PUNCT
admet-1570	19	12	has	have	AUX
admet-1570	19	13	led	lead	VERB
admet-1570	19	14	to	to	ADP
admet-1570	19	15	an	an	DET
admet-1570	19	16	interest	interest	NOUN
admet-1570	19	17	in	in	ADP
admet-1570	19	18	developing	develop	VERB
admet-1570	19	19	physiologically	physiologically	ADV
admet-1570	19	20	based	base	VERB
admet-1570	19	21	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	19	22	modeling	modeling	NOUN
admet-1570	19	23	(	(	PUNCT
admet-1570	19	24	pbpk	pbpk	NOUN
admet-1570	19	25	)	)	PUNCT
admet-1570	19	26	of	of	ADP
admet-1570	19	27	these	these	DET
admet-1570	19	28	proteins	protein	NOUN
admet-1570	19	29	[	[	X
admet-1570	19	30	5	5	NUM
admet-1570	19	31	-	-	SYM
admet-1570	19	32	8	8	NUM
admet-1570	19	33	]	]	PUNCT
admet-1570	19	34	.	.	PUNCT
admet-1570	20	1	in	in	ADP
admet-1570	20	2	this	this	DET
admet-1570	20	3	approach	approach	NOUN
admet-1570	20	4	,	,	PUNCT
admet-1570	20	5	each	each	PRON
admet-1570	20	6	of	of	ADP
admet-1570	20	7	the	the	DET
admet-1570	20	8	major	major	ADJ
admet-1570	20	9	organs	organ	NOUN
admet-1570	20	10	is	be	AUX
admet-1570	20	11	described	describe	VERB
admet-1570	20	12	in	in	ADP
admet-1570	20	13	terms	term	NOUN
admet-1570	20	14	of	of	ADP
admet-1570	20	15	their	their	PRON
admet-1570	20	16	physiological	physiological	ADJ
admet-1570	20	17	parameters	parameter	NOUN
admet-1570	20	18	(	(	PUNCT
admet-1570	20	19	blood	blood	NOUN
admet-1570	20	20	flow	flow	NOUN
admet-1570	20	21	,	,	PUNCT
admet-1570	20	22	capillary	capillary	ADJ
admet-1570	20	23	permeability	permeability	NOUN
admet-1570	20	24	,	,	PUNCT
admet-1570	20	25	lymph	lymph	NOUN
admet-1570	20	26	flow	flow	NOUN
admet-1570	20	27	,	,	PUNCT
admet-1570	20	28	interstitial	interstitial	ADJ
admet-1570	20	29	volume	volume	NOUN
admet-1570	20	30	,	,	PUNCT
admet-1570	20	31	protein	protein	NOUN
admet-1570	20	32	catabolism	catabolism	NOUN
admet-1570	20	33	,	,	PUNCT
admet-1570	20	34	etc	etc	X
admet-1570	20	35	.	.	X
admet-1570	20	36	)	)	PUNCT
admet-1570	21	1	and	and	CCONJ
admet-1570	21	2	the	the	DET
admet-1570	21	3	pk	pk	NOUN
admet-1570	21	4	is	be	AUX
admet-1570	21	5	related	relate	VERB
admet-1570	21	6	to	to	ADP
admet-1570	21	7	these	these	DET
admet-1570	21	8	parameters	parameter	NOUN
admet-1570	21	9	.	.	PUNCT
admet-1570	22	1	the	the	DET
admet-1570	22	2	major	major	ADJ
admet-1570	22	3	theoretical	theoretical	ADJ
admet-1570	22	4	advantage	advantage	NOUN
admet-1570	22	5	of	of	ADP
admet-1570	22	6	this	this	DET
admet-1570	22	7	approach	approach	NOUN
admet-1570	22	8	is	be	AUX
admet-1570	22	9	that	that	SCONJ
admet-1570	22	10	once	once	SCONJ
admet-1570	22	11	these	these	DET
admet-1570	22	12	parameters	parameter	NOUN
admet-1570	22	13	are	be	AUX
admet-1570	22	14	determined	determine	VERB
admet-1570	22	15	for	for	ADP
admet-1570	22	16	,	,	PUNCT
admet-1570	22	17	e.g.	e.g.	ADV
admet-1570	22	18	,	,	PUNCT
admet-1570	22	19	the	the	DET
admet-1570	22	20	human	human	NOUN
admet-1570	22	21	,	,	PUNCT
admet-1570	22	22	they	they	PRON
admet-1570	22	23	allow	allow	VERB
admet-1570	22	24	one	one	PRON
admet-1570	22	25	to	to	PART
admet-1570	22	26	predict	predict	VERB
admet-1570	22	27	the	the	DET
admet-1570	22	28	human	human	ADJ
admet-1570	22	29	protein	protein	NOUN
admet-1570	22	30	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	22	31	of	of	ADP
admet-1570	22	32	a	a	DET
admet-1570	22	33	novel	novel	ADJ
admet-1570	22	34	protein	protein	NOUN
admet-1570	22	35	with	with	ADP
admet-1570	22	36	a	a	DET
admet-1570	22	37	minimum	minimum	NOUN
admet-1570	22	38	of	of	ADP
admet-1570	22	39	adjustable	adjustable	ADJ
admet-1570	22	40	parameters	parameter	NOUN
admet-1570	22	41	.	.	PUNCT
admet-1570	23	1	in	in	ADP
admet-1570	23	2	addition	addition	NOUN
admet-1570	23	3	,	,	PUNCT
admet-1570	23	4	since	since	SCONJ
admet-1570	23	5	each	each	DET
admet-1570	23	6	organ	organ	NOUN
admet-1570	23	7	is	be	AUX
admet-1570	23	8	described	describe	VERB
admet-1570	23	9	individually	individually	ADV
admet-1570	23	10	,	,	PUNCT
admet-1570	23	11	one	one	PRON
admet-1570	23	12	can	can	AUX
admet-1570	23	13	predict	predict	VERB
admet-1570	23	14	their	their	PRON
admet-1570	23	15	individual	individual	ADJ
admet-1570	23	16	tissue	tissue	NOUN
admet-1570	23	17	protein	protein	NOUN
admet-1570	23	18	pk	pk	NOUN
admet-1570	23	19	,	,	PUNCT
admet-1570	23	20	which	which	PRON
admet-1570	23	21	is	be	AUX
admet-1570	23	22	useful	useful	ADJ
admet-1570	23	23	if	if	SCONJ
admet-1570	23	24	trying	try	VERB
admet-1570	23	25	to	to	PART
admet-1570	23	26	direct	direct	VERB
admet-1570	23	27	therapy	therapy	NOUN
admet-1570	23	28	to	to	ADP
admet-1570	23	29	specific	specific	ADJ
admet-1570	23	30	organs	organ	NOUN
admet-1570	23	31	.	.	PUNCT
admet-1570	24	1	although	although	SCONJ
admet-1570	24	2	there	there	PRON
admet-1570	24	3	has	have	AUX
admet-1570	24	4	been	be	AUX
admet-1570	24	5	great	great	ADJ
admet-1570	24	6	interest	interest	NOUN
admet-1570	24	7	in	in	ADP
admet-1570	24	8	the	the	DET
admet-1570	24	9	pk	pk	NOUN
admet-1570	24	10	modeling	modeling	NOUN
admet-1570	24	11	of	of	ADP
admet-1570	24	12	therapeutic	therapeutic	ADJ
admet-1570	24	13	proteins	protein	NOUN
admet-1570	24	14	,	,	PUNCT
admet-1570	24	15	there	there	PRON
admet-1570	24	16	is	be	VERB
admet-1570	24	17	another	another	DET
admet-1570	24	18	class	class	NOUN
admet-1570	24	19	whose	whose	DET
admet-1570	24	20	pk	pk	NOUN
admet-1570	24	21	has	have	AUX
admet-1570	24	22	been	be	AUX
admet-1570	24	23	almost	almost	ADV
admet-1570	24	24	completely	completely	ADV
admet-1570	24	25	ignored	ignore	VERB
admet-1570	24	26	:	:	PUNCT
admet-1570	24	27	the	the	DET
admet-1570	24	28	diagnostic	diagnostic	ADJ
admet-1570	24	29	enzymes	enzyme	NOUN
admet-1570	24	30	such	such	ADJ
admet-1570	24	31	as	as	ADP
admet-1570	24	32	alanine	alanine	NOUN
admet-1570	24	33	transaminase	transaminase	NOUN
admet-1570	24	34	,	,	PUNCT
admet-1570	24	35	aspartate	aspartate	NOUN
admet-1570	24	36	aminotransferase	aminotransferase	NOUN
admet-1570	24	37	,	,	PUNCT
admet-1570	24	38	alkaline	alkaline	NOUN
admet-1570	24	39	phosphatase	phosphatase	NOUN
admet-1570	24	40	,	,	PUNCT
admet-1570	24	41	amylase	amylase	NOUN
admet-1570	24	42	,	,	PUNCT
admet-1570	24	43	etc	etc	X
admet-1570	24	44	.	.	X
admet-1570	24	45	pathological	pathological	ADJ
admet-1570	24	46	disruption	disruption	NOUN
admet-1570	24	47	of	of	ADP
admet-1570	24	48	normal	normal	ADJ
admet-1570	24	49	cellular	cellular	ADJ
admet-1570	24	50	structure	structure	NOUN
admet-1570	24	51	may	may	AUX
admet-1570	24	52	result	result	VERB
admet-1570	24	53	in	in	ADP
admet-1570	24	54	the	the	DET
admet-1570	24	55	release	release	NOUN
admet-1570	24	56	of	of	ADP
admet-1570	24	57	these	these	DET
admet-1570	24	58	cellular	cellular	ADJ
admet-1570	24	59	proteins	protein	NOUN
admet-1570	24	60	to	to	ADP
admet-1570	24	61	the	the	DET
admet-1570	24	62	interstitial	interstitial	ADJ
admet-1570	24	63	space	space	NOUN
admet-1570	24	64	,	,	PUNCT
admet-1570	24	65	with	with	ADP
admet-1570	24	66	subsequent	subsequent	ADJ
admet-1570	24	67	transport	transport	NOUN
admet-1570	24	68	to	to	ADP
admet-1570	24	69	the	the	DET
admet-1570	24	70	plasma	plasma	NOUN
admet-1570	24	71	.	.	PUNCT
admet-1570	25	1	because	because	SCONJ
admet-1570	25	2	low	low	ADJ
admet-1570	25	3	concentrations	concentration	NOUN
admet-1570	25	4	of	of	ADP
admet-1570	25	5	cellular	cellular	ADJ
admet-1570	25	6	enzymes	enzyme	NOUN
admet-1570	25	7	are	be	AUX
admet-1570	25	8	easily	easily	ADV
admet-1570	25	9	quantified	quantify	VERB
admet-1570	25	10	via	via	ADP
admet-1570	25	11	activity	activity	NOUN
admet-1570	25	12	measurements	measurement	NOUN
admet-1570	25	13	,	,	PUNCT
admet-1570	25	14	plasma	plasma	NOUN
admet-1570	25	15	enzyme	enzyme	NOUN
admet-1570	25	16	values	value	NOUN
admet-1570	25	17	are	be	AUX
admet-1570	25	18	widely	widely	ADV
admet-1570	25	19	used	use	VERB
admet-1570	25	20	as	as	ADP
admet-1570	25	21	routine	routine	ADJ
admet-1570	25	22	screening	screening	NOUN
admet-1570	25	23	tests	test	NOUN
admet-1570	25	24	for	for	ADP
admet-1570	25	25	a	a	DET
admet-1570	25	26	variety	variety	NOUN
admet-1570	25	27	of	of	ADP
admet-1570	25	28	conditions	condition	NOUN
admet-1570	25	29	as	as	ADV
admet-1570	25	30	well	well	ADV
admet-1570	25	31	as	as	ADP
admet-1570	25	32	for	for	ADP
admet-1570	25	33	evaluating	evaluate	VERB
admet-1570	25	34	the	the	DET
admet-1570	25	35	severity	severity	NOUN
admet-1570	25	36	of	of	ADP
admet-1570	25	37	specific	specific	ADJ
admet-1570	25	38	disease	disease	NOUN
admet-1570	25	39	states	state	NOUN
admet-1570	25	40	.	.	PUNCT
admet-1570	26	1	these	these	DET
admet-1570	26	2	diagnostic	diagnostic	ADJ
admet-1570	26	3	enzymes	enzyme	NOUN
admet-1570	26	4	are	be	AUX
admet-1570	26	5	typically	typically	ADV
admet-1570	26	6	characterized	characterize	VERB
admet-1570	26	7	by	by	ADP
admet-1570	26	8	estimates	estimate	NOUN
admet-1570	26	9	of	of	ADP
admet-1570	26	10	their	their	PRON
admet-1570	26	11	“	"	PUNCT
admet-1570	26	12	half	half	ADJ
admet-1570	26	13	-	-	PUNCT
admet-1570	26	14	life	life	NOUN
admet-1570	26	15	”	"	PUNCT
admet-1570	26	16	,	,	PUNCT
admet-1570	26	17	based	base	VERB
admet-1570	26	18	primarily	primarily	ADV
admet-1570	26	19	on	on	ADP
admet-1570	26	20	the	the	DET
admet-1570	26	21	time	time	NOUN
admet-1570	26	22	course	course	NOUN
admet-1570	26	23	of	of	ADP
admet-1570	26	24	the	the	DET
admet-1570	26	25	fall	fall	NOUN
admet-1570	26	26	in	in	ADP
admet-1570	26	27	the	the	DET
admet-1570	26	28	plasma	plasma	NOUN
admet-1570	26	29	concentration	concentration	NOUN
admet-1570	26	30	following	follow	VERB
admet-1570	26	31	the	the	DET
admet-1570	26	32	resolution	resolution	NOUN
admet-1570	26	33	of	of	ADP
admet-1570	26	34	the	the	DET
admet-1570	26	35	problem	problem	NOUN
admet-1570	26	36	causing	cause	VERB
admet-1570	26	37	the	the	DET
admet-1570	26	38	enzyme	enzyme	NOUN
admet-1570	26	39	elevation	elevation	NOUN
admet-1570	26	40	.	.	PUNCT
admet-1570	27	1	lindena	lindena	PROPN
admet-1570	27	2	et	et	PROPN
admet-1570	27	3	al	al	PROPN
admet-1570	27	4	.	.	PUNCT
admet-1570	28	1	[	[	X
admet-1570	28	2	9	9	NUM
admet-1570	28	3	]	]	PUNCT
admet-1570	28	4	have	have	AUX
admet-1570	28	5	presented	present	VERB
admet-1570	28	6	a	a	DET
admet-1570	28	7	remarkably	remarkably	ADV
admet-1570	28	8	thorough	thorough	ADJ
admet-1570	28	9	compilation	compilation	NOUN
admet-1570	28	10	of	of	ADP
admet-1570	28	11	this	this	DET
admet-1570	28	12	older	old	ADJ
admet-1570	28	13	data	datum	NOUN
admet-1570	28	14	,	,	PUNCT
admet-1570	28	15	comparing	compare	VERB
admet-1570	28	16	the	the	DET
admet-1570	28	17	reported	report	VERB
admet-1570	28	18	half	half	ADJ
admet-1570	28	19	-	-	PUNCT
admet-1570	28	20	lives	life	NOUN
admet-1570	28	21	for	for	ADP
admet-1570	28	22	man	man	NOUN
admet-1570	28	23	,	,	PUNCT
admet-1570	28	24	dog	dog	NOUN
admet-1570	28	25	and	and	CCONJ
admet-1570	28	26	rat	rat	NOUN
admet-1570	28	27	.	.	PUNCT
admet-1570	29	1	these	these	DET
admet-1570	29	2	estimates	estimate	NOUN
admet-1570	29	3	are	be	AUX
admet-1570	29	4	only	only	ADV
admet-1570	29	5	approximate	approximate	ADJ
admet-1570	29	6	because	because	SCONJ
admet-1570	29	7	of	of	ADP
admet-1570	29	8	the	the	DET
admet-1570	29	9	lack	lack	NOUN
admet-1570	29	10	of	of	ADP
admet-1570	29	11	quantitative	quantitative	ADJ
admet-1570	29	12	information	information	NOUN
admet-1570	29	13	about	about	ADP
admet-1570	29	14	the	the	DET
admet-1570	29	15	ongoing	ongoing	ADJ
admet-1570	29	16	release	release	NOUN
admet-1570	29	17	of	of	ADP
admet-1570	29	18	the	the	DET
admet-1570	29	19	enzymes	enzyme	NOUN
admet-1570	29	20	and/or	and/or	CCONJ
admet-1570	29	21	recycling	recycling	NOUN
admet-1570	29	22	from	from	ADP
admet-1570	29	23	the	the	DET
admet-1570	29	24	tissue	tissue	NOUN
admet-1570	29	25	space	space	NOUN
admet-1570	29	26	.	.	PUNCT
admet-1570	30	1	physicians	physician	NOUN
admet-1570	30	2	tend	tend	VERB
admet-1570	30	3	to	to	PART
admet-1570	30	4	interpret	interpret	VERB
admet-1570	30	5	plasma	plasma	NOUN
admet-1570	30	6	protein	protein	NOUN
admet-1570	30	7	concentrations	concentration	NOUN
admet-1570	30	8	primarily	primarily	ADV
admet-1570	30	9	as	as	ADP
admet-1570	30	10	an	an	DET
admet-1570	30	11	indicator	indicator	NOUN
admet-1570	30	12	of	of	ADP
admet-1570	30	13	a	a	DET
admet-1570	30	14	disordered	disordered	ADJ
admet-1570	30	15	rate	rate	NOUN
admet-1570	30	16	of	of	ADP
admet-1570	30	17	delivery	delivery	NOUN
admet-1570	30	18	to	to	ADP
admet-1570	30	19	the	the	DET
admet-1570	30	20	plasma	plasma	NOUN
admet-1570	30	21	.	.	PUNCT
admet-1570	31	1	details	detail	NOUN
admet-1570	31	2	of	of	ADP
admet-1570	31	3	the	the	DET
admet-1570	31	4	pk	pk	NOUN
admet-1570	31	5	:	:	PUNCT
admet-1570	31	6	rate	rate	NOUN
admet-1570	31	7	of	of	ADP
admet-1570	31	8	release	release	NOUN
admet-1570	31	9	into	into	ADP
admet-1570	31	10	the	the	DET
admet-1570	31	11	blood	blood	NOUN
admet-1570	31	12	,	,	PUNCT
admet-1570	31	13	time	time	NOUN
admet-1570	31	14	course	course	NOUN
admet-1570	31	15	and	and	CCONJ
admet-1570	31	16	details	detail	NOUN
admet-1570	31	17	of	of	ADP
admet-1570	31	18	the	the	DET
admet-1570	31	19	extravascular	extravascular	ADJ
admet-1570	31	20	distribution	distribution	NOUN
admet-1570	31	21	,	,	PUNCT
admet-1570	31	22	and	and	CCONJ
admet-1570	31	23	site	site	NOUN
admet-1570	31	24	and	and	CCONJ
admet-1570	31	25	rate	rate	NOUN
admet-1570	31	26	of	of	ADP
admet-1570	31	27	removal	removal	NOUN
admet-1570	31	28	usually	usually	ADV
admet-1570	31	29	are	be	AUX
admet-1570	31	30	ignored	ignore	VERB
admet-1570	31	31	.	.	PUNCT
admet-1570	32	1	a	a	DET
admet-1570	32	2	quantitative	quantitative	ADJ
admet-1570	32	3	description	description	NOUN
admet-1570	32	4	of	of	ADP
admet-1570	32	5	the	the	DET
admet-1570	32	6	pk	pk	NOUN
admet-1570	32	7	of	of	ADP
admet-1570	32	8	these	these	DET
admet-1570	32	9	commonly	commonly	ADV
admet-1570	32	10	measured	measure	VERB
admet-1570	32	11	plasma	plasma	NOUN
admet-1570	32	12	proteins	protein	NOUN
admet-1570	32	13	,	,	PUNCT
admet-1570	32	14	with	with	ADP
admet-1570	32	15	an	an	DET
admet-1570	32	16	emphasis	emphasis	NOUN
admet-1570	32	17	on	on	ADP
admet-1570	32	18	the	the	DET
admet-1570	32	19	roles	role	NOUN
admet-1570	32	20	of	of	ADP
admet-1570	32	21	distribution	distribution	NOUN
admet-1570	32	22	and	and	CCONJ
admet-1570	32	23	elimination	elimination	NOUN
admet-1570	32	24	rates	rate	NOUN
admet-1570	32	25	as	as	ADP
admet-1570	32	26	determinants	determinant	NOUN
admet-1570	32	27	of	of	ADP
admet-1570	32	28	plasma	plasma	NOUN
admet-1570	32	29	concentrations	concentration	NOUN
admet-1570	32	30	,	,	PUNCT
admet-1570	32	31	should	should	AUX
admet-1570	32	32	aid	aid	VERB
admet-1570	32	33	in	in	ADP
admet-1570	32	34	the	the	DET
admet-1570	32	35	clinical	clinical	ADJ
admet-1570	32	36	interpretation	interpretation	NOUN
admet-1570	32	37	of	of	ADP
admet-1570	32	38	the	the	DET
admet-1570	32	39	time	time	NOUN
admet-1570	32	40	course	course	NOUN
admet-1570	32	41	of	of	ADP
admet-1570	32	42	the	the	DET
admet-1570	32	43	plasma	plasma	NOUN
admet-1570	32	44	concentration	concentration	NOUN
admet-1570	32	45	.	.	PUNCT
admet-1570	33	1	in	in	ADP
admet-1570	33	2	this	this	DET
admet-1570	33	3	review	review	NOUN
admet-1570	33	4	,	,	PUNCT
admet-1570	33	5	we	we	PRON
admet-1570	33	6	will	will	AUX
admet-1570	33	7	first	first	ADV
admet-1570	33	8	discuss	discuss	VERB
admet-1570	33	9	the	the	DET
admet-1570	33	10	compartmental	compartmental	NOUN
admet-1570	33	11	and	and	CCONJ
admet-1570	33	12	pbpk	pbpk	ADJ
admet-1570	33	13	approach	approach	NOUN
admet-1570	33	14	to	to	ADP
admet-1570	33	15	protein	protein	NOUN
admet-1570	33	16	pk	pk	NOUN
admet-1570	33	17	.	.	PUNCT
admet-1570	34	1	we	we	PRON
admet-1570	34	2	will	will	AUX
admet-1570	34	3	show	show	VERB
admet-1570	34	4	that	that	SCONJ
admet-1570	34	5	,	,	PUNCT
admet-1570	34	6	although	although	SCONJ
admet-1570	34	7	the	the	DET
admet-1570	34	8	full	full	ADJ
admet-1570	34	9	pbpk	pbpk	ADJ
admet-1570	34	10	approach	approach	NOUN
admet-1570	34	11	is	be	AUX
admet-1570	34	12	probably	probably	ADV
admet-1570	34	13	not	not	PART
admet-1570	34	14	feasible	feasible	ADJ
admet-1570	34	15	for	for	ADP
admet-1570	34	16	most	most	ADJ
admet-1570	34	17	proteins	protein	NOUN
admet-1570	34	18	,	,	PUNCT
admet-1570	34	19	the	the	DET
admet-1570	34	20	use	use	NOUN
admet-1570	34	21	of	of	ADP
admet-1570	34	22	a	a	DET
admet-1570	34	23	simpler	simple	ADJ
admet-1570	34	24	physiological	physiological	ADJ
admet-1570	34	25	model	model	NOUN
admet-1570	34	26	,	,	PUNCT
admet-1570	34	27	in	in	ADP
admet-1570	34	28	which	which	PRON
admet-1570	34	29	some	some	DET
admet-1570	34	30	organs	organ	NOUN
admet-1570	34	31	are	be	AUX
admet-1570	34	32	lumped	lump	VERB
admet-1570	34	33	together	together	ADV
admet-1570	34	34	,	,	PUNCT
admet-1570	34	35	is	be	AUX
admet-1570	34	36	useful	useful	ADJ
admet-1570	34	37	.	.	PUNCT
admet-1570	35	1	we	we	PRON
admet-1570	35	2	describe	describe	VERB
admet-1570	35	3	a	a	DET
admet-1570	35	4	new	new	ADJ
admet-1570	35	5	model	model	NOUN
admet-1570	35	6	that	that	PRON
admet-1570	35	7	provides	provide	VERB
admet-1570	35	8	an	an	DET
admet-1570	35	9	accurate	accurate	ADJ
admet-1570	35	10	description	description	NOUN
admet-1570	35	11	of	of	ADP
admet-1570	35	12	the	the	DET
admet-1570	35	13	plasma	plasma	NOUN
admet-1570	35	14	pk	pk	NOUN
admet-1570	35	15	requiring	require	VERB
admet-1570	35	16	,	,	PUNCT
admet-1570	35	17	for	for	ADP
admet-1570	35	18	a	a	DET
admet-1570	35	19	given	give	VERB
admet-1570	35	20	species	specie	NOUN
admet-1570	35	21	,	,	PUNCT
admet-1570	35	22	only	only	ADV
admet-1570	35	23	2	2	NUM
admet-1570	35	24	adjustable	adjustable	ADJ
admet-1570	35	25	parameters	parameter	NOUN
admet-1570	35	26	to	to	PART
admet-1570	35	27	characterize	characterize	VERB
admet-1570	35	28	each	each	DET
admet-1570	35	29	protein	protein	NOUN
admet-1570	35	30	.	.	PUNCT
admet-1570	36	1	plasma	plasma	NOUN
admet-1570	36	2	protein	protein	NOUN
admet-1570	36	3	pk	pk	NOUN
admet-1570	36	4	are	be	AUX
admet-1570	36	5	quite	quite	ADV
admet-1570	36	6	simple	simple	ADJ
admet-1570	36	7	and	and	CCONJ
admet-1570	36	8	can	can	AUX
admet-1570	36	9	be	be	AUX
admet-1570	36	10	described	describe	VERB
admet-1570	36	11	by	by	ADP
admet-1570	36	12	a	a	DET
admet-1570	36	13	variety	variety	NOUN
admet-1570	36	14	of	of	ADP
admet-1570	36	15	kinetic	kinetic	ADJ
admet-1570	36	16	models	model	NOUN
admet-1570	36	17	.	.	PUNCT
admet-1570	37	1	an	an	DET
admet-1570	37	2	important	important	ADJ
admet-1570	37	3	constraint	constraint	NOUN
admet-1570	37	4	on	on	ADP
admet-1570	37	5	the	the	DET
admet-1570	37	6	model	model	NOUN
admet-1570	37	7	validity	validity	NOUN
admet-1570	37	8	is	be	AUX
admet-1570	37	9	its	its	PRON
admet-1570	37	10	ability	ability	NOUN
admet-1570	37	11	to	to	PART
admet-1570	37	12	describe	describe	VERB
admet-1570	37	13	the	the	DET
admet-1570	37	14	simultaneous	simultaneous	ADJ
admet-1570	37	15	tissue	tissue	NOUN
admet-1570	37	16	or	or	CCONJ
admet-1570	37	17	lymph	lymph	NOUN
admet-1570	37	18	concentration	concentration	NOUN
admet-1570	37	19	,	,	PUNCT
admet-1570	37	20	an	an	DET
admet-1570	37	21	additional	additional	ADJ
admet-1570	37	22	constraint	constraint	NOUN
admet-1570	37	23	that	that	PRON
admet-1570	37	24	is	be	AUX
admet-1570	37	25	rarely	rarely	ADV
admet-1570	37	26	discussed	discuss	VERB
admet-1570	37	27	.	.	PUNCT
admet-1570	38	1	we	we	PRON
admet-1570	38	2	show	show	VERB
admet-1570	38	3	that	that	SCONJ
admet-1570	38	4	,	,	PUNCT
admet-1570	38	5	in	in	ADP
admet-1570	38	6	addition	addition	NOUN
admet-1570	38	7	to	to	ADP
admet-1570	38	8	describing	describe	VERB
admet-1570	38	9	the	the	DET
admet-1570	38	10	plasma	plasma	NOUN
admet-1570	38	11	concentration	concentration	NOUN
admet-1570	38	12	,	,	PUNCT
admet-1570	38	13	this	this	DET
admet-1570	38	14	model	model	NOUN
admet-1570	38	15	is	be	AUX
admet-1570	38	16	surprisingly	surprisingly	ADV
admet-1570	38	17	successful	successful	ADJ
admet-1570	38	18	at	at	ADP
admet-1570	38	19	predicting	predict	VERB
admet-1570	38	20	the	the	DET
admet-1570	38	21	lymph	lymph	NOUN
admet-1570	38	22	and	and	CCONJ
admet-1570	38	23	tissue	tissue	NOUN
admet-1570	38	24	concentration	concentration	NOUN
admet-1570	38	25	,	,	PUNCT
admet-1570	38	26	a	a	DET
admet-1570	38	27	result	result	NOUN
admet-1570	38	28	that	that	PRON
admet-1570	38	29	provides	provide	VERB
admet-1570	38	30	additional	additional	ADJ
admet-1570	38	31	support	support	NOUN
admet-1570	38	32	for	for	ADP
admet-1570	38	33	the	the	DET
admet-1570	38	34	validity	validity	NOUN
admet-1570	38	35	of	of	ADP
admet-1570	38	36	the	the	DET
admet-1570	38	37	model	model	NOUN
admet-1570	38	38	.	.	PUNCT
admet-1570	39	1	our	our	PRON
admet-1570	39	2	model	model	NOUN
admet-1570	39	3	is	be	AUX
admet-1570	39	4	much	much	ADV
admet-1570	39	5	simpler	simple	ADJ
admet-1570	39	6	and	and	CCONJ
admet-1570	39	7	,	,	PUNCT
admet-1570	39	8	therefore	therefore	ADV
admet-1570	39	9	,	,	PUNCT
admet-1570	39	10	more	more	ADV
admet-1570	39	11	limited	limited	ADJ
admet-1570	39	12	than	than	ADP
admet-1570	39	13	some	some	PRON
admet-1570	39	14	of	of	ADP
admet-1570	39	15	the	the	DET
admet-1570	39	16	detailed	detailed	ADJ
admet-1570	39	17	pbpk	pbpk	NOUN
admet-1570	39	18	models	model	NOUN
admet-1570	39	19	that	that	PRON
admet-1570	39	20	have	have	AUX
admet-1570	39	21	been	be	AUX
admet-1570	39	22	developed	develop	VERB
admet-1570	39	23	for	for	ADP
admet-1570	39	24	the	the	DET
admet-1570	39	25	monoclonals	monoclonal	NOUN
admet-1570	39	26	[	[	X
admet-1570	39	27	8	8	NUM
admet-1570	39	28	]	]	PUNCT
admet-1570	39	29	.	.	PUNCT
admet-1570	40	1	we	we	PRON
admet-1570	40	2	believe	believe	VERB
admet-1570	40	3	that	that	SCONJ
admet-1570	40	4	this	this	DET
admet-1570	40	5	simplicity	simplicity	NOUN
admet-1570	40	6	and	and	CCONJ
admet-1570	40	7	its	its	PRON
admet-1570	40	8	ability	ability	NOUN
admet-1570	40	9	to	to	PART
admet-1570	40	10	describe	describe	VERB
admet-1570	40	11	a	a	DET
admet-1570	40	12	wide	wide	ADJ
admet-1570	40	13	range	range	NOUN
admet-1570	40	14	of	of	ADP
admet-1570	40	15	proteins	protein	NOUN
admet-1570	40	16	compensate	compensate	NOUN
admet-1570	40	17	for	for	ADP
admet-1570	40	18	these	these	DET
admet-1570	40	19	limitations	limitation	NOUN
admet-1570	40	20	.	.	PUNCT
admet-1570	41	1	we	we	PRON
admet-1570	41	2	will	will	AUX
admet-1570	41	3	first	first	ADV
admet-1570	41	4	discuss	discuss	VERB
admet-1570	41	5	and	and	CCONJ
admet-1570	41	6	illustrate	illustrate	VERB
admet-1570	41	7	compartmental	compartmental	NOUN
admet-1570	41	8	and	and	CCONJ
admet-1570	41	9	physiological	physiological	ADJ
admet-1570	41	10	pk	pk	NOUN
admet-1570	41	11	modeling	modeling	NOUN
admet-1570	41	12	by	by	ADP
admet-1570	41	13	applying	apply	VERB
admet-1570	41	14	it	it	PRON
admet-1570	41	15	to	to	ADP
admet-1570	41	16	albumin	albumin	NOUN
admet-1570	41	17	,	,	PUNCT
admet-1570	41	18	the	the	DET
admet-1570	41	19	most	most	ADV
admet-1570	41	20	extensively	extensively	ADV
admet-1570	41	21	studied	study	VERB
admet-1570	41	22	plasma	plasma	NOUN
admet-1570	41	23	protein	protein	NOUN
admet-1570	41	24	(	(	PUNCT
admet-1570	41	25	section	section	NOUN
admet-1570	41	26	ii	ii	PROPN
admet-1570	41	27	)	)	PUNCT
admet-1570	41	28	.	.	PUNCT
admet-1570	42	1	then	then	ADV
admet-1570	42	2	,	,	PUNCT
admet-1570	42	3	in	in	ADP
admet-1570	42	4	the	the	DET
admet-1570	42	5	following	follow	VERB
admet-1570	42	6	sections	section	NOUN
admet-1570	42	7	,	,	PUNCT
admet-1570	42	8	this	this	DET
admet-1570	42	9	physiological	physiological	ADJ
admet-1570	42	10	model	model	NOUN
admet-1570	42	11	will	will	AUX
admet-1570	42	12	be	be	AUX
admet-1570	42	13	applied	apply	VERB
admet-1570	42	14	to	to	ADP
admet-1570	42	15	the	the	DET
admet-1570	42	16	monoclonal	monoclonal	NOUN
admet-1570	42	17	antibodies	antibody	NOUN
admet-1570	42	18	(	(	PUNCT
admet-1570	42	19	section	section	NOUN
admet-1570	42	20	iii	iii	NOUN
admet-1570	42	21	)	)	PUNCT
admet-1570	42	22	and	and	CCONJ
admet-1570	42	23	the	the	DET
admet-1570	42	24	diagnostic	diagnostic	ADJ
admet-1570	42	25	enzymes	enzyme	NOUN
admet-1570	42	26	(	(	PUNCT
admet-1570	42	27	sections	section	NOUN
admet-1570	42	28	iv	iv	NUM
admet-1570	42	29	–	–	PUNCT
admet-1570	42	30	viii	viii	NOUN
admet-1570	42	31	)	)	PUNCT
admet-1570	42	32	.	.	PUNCT
admet-1570	43	1	the	the	DET
admet-1570	43	2	resultant	resultant	NOUN
admet-1570	43	3	pk	pk	NOUN
admet-1570	43	4	parameters	parameter	NOUN
admet-1570	43	5	for	for	ADP
admet-1570	43	6	the	the	DET
admet-1570	43	7	13	13	NUM
admet-1570	43	8	proteins	protein	NOUN
admet-1570	43	9	investigated	investigate	VERB
admet-1570	43	10	are	be	AUX
admet-1570	43	11	summarized	summarize	VERB
admet-1570	43	12	in	in	ADP
admet-1570	43	13	table	table	NOUN
admet-1570	43	14	1	1	NUM
admet-1570	43	15	in	in	ADP
admet-1570	43	16	terms	term	NOUN
admet-1570	43	17	of	of	ADP
admet-1570	43	18	the	the	DET
admet-1570	43	19	admet	admet	PROPN
admet-1570	43	20	&	&	CCONJ
admet-1570	43	21	dmpk	dmpk	PROPN
admet-1570	43	22	11(1	11(1	NUM
admet-1570	43	23	)	)	PUNCT
admet-1570	43	24	(	(	PUNCT
admet-1570	43	25	2023	2023	NUM
admet-1570	43	26	)	)	PUNCT
admet-1570	43	27	57	57	NUM
admet-1570	43	28	-	-	SYM
admet-1570	43	29	80	80	NUM
admet-1570	43	30	protein	protein	NOUN
admet-1570	43	31	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	43	32	model	model	NOUN
admet-1570	43	33	doi	doi	PROPN
admet-1570	43	34	:	:	PUNCT
admet-1570	43	35	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	43	36	59	59	NUM
admet-1570	43	37	compartmental	compartmental	ADJ
admet-1570	43	38	parameters	parameter	NOUN
admet-1570	43	39	and	and	CCONJ
admet-1570	43	40	in	in	ADP
admet-1570	43	41	table	table	NOUN
admet-1570	43	42	2	2	NUM
admet-1570	43	43	in	in	ADP
admet-1570	43	44	terms	term	NOUN
admet-1570	43	45	of	of	ADP
admet-1570	43	46	the	the	DET
admet-1570	43	47	physiological	physiological	ADJ
admet-1570	43	48	parameters	parameter	NOUN
admet-1570	43	49	.	.	PUNCT
admet-1570	44	1	the	the	DET
admet-1570	44	2	range	range	NOUN
admet-1570	44	3	of	of	ADP
admet-1570	44	4	proteins	protein	NOUN
admet-1570	44	5	analyzed	analyze	VERB
admet-1570	44	6	is	be	AUX
admet-1570	44	7	limited	limit	VERB
admet-1570	44	8	by	by	ADP
admet-1570	44	9	the	the	DET
admet-1570	44	10	available	available	ADJ
admet-1570	44	11	pk	pk	PROPN
admet-1570	44	12	data	datum	NOUN
admet-1570	44	13	.	.	PUNCT
admet-1570	45	1	the	the	DET
admet-1570	45	2	ideal	ideal	NOUN
admet-1570	45	3	would	would	AUX
admet-1570	45	4	be	be	AUX
admet-1570	45	5	human	human	ADJ
admet-1570	45	6	data	datum	NOUN
admet-1570	45	7	for	for	ADP
admet-1570	45	8	the	the	DET
admet-1570	45	9	plasma	plasma	NOUN
admet-1570	45	10	time	time	NOUN
admet-1570	45	11	course	course	NOUN
admet-1570	45	12	of	of	ADP
admet-1570	45	13	an	an	DET
admet-1570	45	14	intravenous	intravenous	ADJ
admet-1570	45	15	(	(	PUNCT
admet-1570	45	16	iv	iv	X
admet-1570	45	17	)	)	PUNCT
admet-1570	45	18	bolus	bolus	NOUN
admet-1570	45	19	of	of	ADP
admet-1570	45	20	the	the	DET
admet-1570	45	21	purified	purified	ADJ
admet-1570	45	22	human	human	ADJ
admet-1570	45	23	protein	protein	NOUN
admet-1570	45	24	.	.	PUNCT
admet-1570	46	1	for	for	ADP
admet-1570	46	2	the	the	DET
admet-1570	46	3	proteins	protein	NOUN
admet-1570	46	4	where	where	SCONJ
admet-1570	46	5	these	these	DET
admet-1570	46	6	data	datum	NOUN
admet-1570	46	7	do	do	AUX
admet-1570	46	8	not	not	PART
admet-1570	46	9	exist	exist	VERB
admet-1570	46	10	,	,	PUNCT
admet-1570	46	11	we	we	PRON
admet-1570	46	12	assumed	assume	VERB
admet-1570	46	13	that	that	SCONJ
admet-1570	46	14	data	datum	NOUN
admet-1570	46	15	from	from	ADP
admet-1570	46	16	studies	study	NOUN
admet-1570	46	17	in	in	ADP
admet-1570	46	18	large	large	ADJ
admet-1570	46	19	mammals	mammal	NOUN
admet-1570	46	20	(	(	PUNCT
admet-1570	46	21	e.g.	e.g.	ADV
admet-1570	46	22	,	,	PUNCT
admet-1570	46	23	dog	dog	NOUN
admet-1570	46	24	,	,	PUNCT
admet-1570	46	25	lamb	lamb	PROPN
admet-1570	46	26	,	,	PUNCT
admet-1570	46	27	baboon	baboon	PROPN
admet-1570	46	28	)	)	PUNCT
admet-1570	46	29	can	can	AUX
admet-1570	46	30	be	be	AUX
admet-1570	46	31	extrapolated	extrapolate	VERB
admet-1570	46	32	to	to	ADP
admet-1570	46	33	the	the	DET
admet-1570	46	34	human	human	NOUN
admet-1570	46	35	.	.	PUNCT
admet-1570	47	1	rat	rat	NOUN
admet-1570	47	2	data	datum	NOUN
admet-1570	47	3	is	be	AUX
admet-1570	47	4	only	only	ADV
admet-1570	47	5	sparingly	sparingly	ADV
admet-1570	47	6	employed	employ	VERB
admet-1570	47	7	because	because	SCONJ
admet-1570	47	8	the	the	DET
admet-1570	47	9	extrapolation	extrapolation	NOUN
admet-1570	47	10	of	of	ADP
admet-1570	47	11	rat	rat	NOUN
admet-1570	47	12	pk	pk	PROPN
admet-1570	47	13	data	datum	NOUN
admet-1570	47	14	to	to	ADP
admet-1570	47	15	humans	human	NOUN
admet-1570	47	16	is	be	AUX
admet-1570	47	17	uncertain	uncertain	ADJ
admet-1570	47	18	.	.	PUNCT
admet-1570	48	1	table	table	NOUN
admet-1570	48	2	1	1	NUM
admet-1570	48	3	.	.	PUNCT
admet-1570	49	1	summary	summary	NOUN
admet-1570	49	2	of	of	ADP
admet-1570	49	3	protein	protein	NOUN
admet-1570	49	4	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	49	5	expressed	express	VERB
admet-1570	49	6	in	in	ADP
admet-1570	49	7	terms	term	NOUN
admet-1570	49	8	of	of	ADP
admet-1570	49	9	the	the	DET
admet-1570	49	10	5	5	NUM
admet-1570	49	11	compartmental	compartmental	ADJ
admet-1570	49	12	time	time	NOUN
admet-1570	49	13	constants	constant	NOUN
admet-1570	49	14	corresponding	correspond	VERB
admet-1570	49	15	to	to	ADP
admet-1570	49	16	the	the	DET
admet-1570	49	17	steady	steady	ADJ
admet-1570	49	18	state	state	NOUN
admet-1570	49	19	parameters	parameter	NOUN
admet-1570	49	20	of	of	ADP
admet-1570	49	21	figure	figure	NOUN
admet-1570	49	22	1a	1a	NOUN
admet-1570	49	23	.	.	PUNCT
admet-1570	50	1	all	all	DET
admet-1570	50	2	results	result	NOUN
admet-1570	50	3	are	be	AUX
admet-1570	50	4	scaled	scale	VERB
admet-1570	50	5	to	to	ADP
admet-1570	50	6	a	a	DET
admet-1570	50	7	70	70	NUM
admet-1570	50	8	kg	kg	NOUN
admet-1570	50	9	human	human	NOUN
admet-1570	50	10	.	.	PUNCT
admet-1570	51	1	“	"	PUNCT
admet-1570	51	2	kupffer	kupffer	NOUN
admet-1570	51	3	”	"	PUNCT
admet-1570	51	4	indicate	indicate	VERB
admet-1570	51	5	liver	liver	NOUN
admet-1570	51	6	kupffer	kupffer	NOUN
admet-1570	51	7	cells	cell	NOUN
admet-1570	51	8	and	and	CCONJ
admet-1570	51	9	“	"	PUNCT
admet-1570	51	10	sinusoidal	sinusoidal	NOUN
admet-1570	51	11	”	"	PUNCT
admet-1570	51	12	are	be	AUX
admet-1570	51	13	liver	liver	ADJ
admet-1570	51	14	parenchymal	parenchymal	ADJ
admet-1570	51	15	cells	cell	NOUN
admet-1570	51	16	.	.	PUNCT
admet-1570	52	1	(	(	PUNCT
admet-1570	52	2	*	*	PUNCT
admet-1570	52	3	*	*	PUNCT
admet-1570	52	4	a	a	DET
admet-1570	52	5	pk	pk	NOUN
admet-1570	52	6	model	model	NOUN
admet-1570	52	7	with	with	ADP
admet-1570	52	8	an	an	DET
admet-1570	52	9	additional	additional	ADJ
admet-1570	52	10	liver	liver	NOUN
admet-1570	52	11	compartment	compartment	NOUN
admet-1570	52	12	is	be	AUX
admet-1570	52	13	used	use	VERB
admet-1570	52	14	for	for	ADP
admet-1570	52	15	recap	recap	NOUN
admet-1570	52	16	.	.	PUNCT
admet-1570	53	1	*	*	PUNCT
admet-1570	53	2	tm	tm	NOUN
admet-1570	53	3	for	for	ADP
admet-1570	53	4	recap	recap	NOUN
admet-1570	53	5	corresponds	correspond	NOUN
admet-1570	53	6	to	to	ADP
admet-1570	53	7	the	the	DET
admet-1570	53	8	liver	liver	NOUN
admet-1570	53	9	metabolic	metabolic	NOUN
admet-1570	53	10	time	time	NOUN
admet-1570	53	11	constant	constant	ADJ
admet-1570	53	12	.	.	PUNCT
admet-1570	53	13	)	)	PUNCT
admet-1570	54	1	protein	protein	NOUN
admet-1570	54	2	species	specie	NOUN
admet-1570	54	3	mw	mw	VERB
admet-1570	54	4	catabolic	catabolic	ADJ
admet-1570	54	5	organ	organ	NOUN
admet-1570	54	6	tm	tm	PROPN
admet-1570	54	7	min	min	PROPN
admet-1570	54	8	tp1	tp1	PROPN
admet-1570	54	9	min	min	PROPN
admet-1570	55	1	tp2	tp2	PROPN
admet-1570	55	2	min	min	PROPN
admet-1570	55	3	tt1	tt1	PROPN
admet-1570	55	4	min	min	PROPN
admet-1570	55	5	tt2	tt2	PROPN
admet-1570	55	6	min	min	PROPN
admet-1570	55	7	albumin	albumin	PROPN
admet-1570	55	8	human	human	PROPN
admet-1570	55	9	66,500	66,500	NUM
admet-1570	55	10	endothelium	endothelium	NOUN
admet-1570	55	11	16,750	16,750	NUM
admet-1570	55	12	4385	4385	NUM
admet-1570	55	13	1929	1929	NUM
admet-1570	55	14	4182	4182	NUM
admet-1570	55	15	557	557	NUM
admet-1570	55	16	monoclonal	monoclonal	NOUN
admet-1570	55	17	antibody	antibody	NOUN
admet-1570	55	18	human	human	ADJ
admet-1570	55	19	mepolizumab	mepolizumab	NOUN
admet-1570	55	20	149,000	149,000	NUM
admet-1570	55	21	endothelium	endothelium	NOUN
admet-1570	55	22	21202	21202	NUM
admet-1570	55	23	8770	8770	NUM
admet-1570	55	24	3859	3859	NUM
admet-1570	55	25	4182	4182	NUM
admet-1570	55	26	557	557	NUM
admet-1570	55	27	infliximab	infliximab	NOUN
admet-1570	55	28	149,000	149,000	NUM
admet-1570	55	29	endothelium	endothelium	NOUN
admet-1570	55	30	11964	11964	NUM
admet-1570	55	31	8770	8770	NUM
admet-1570	55	32	3895	3895	NUM
admet-1570	55	33	4182	4182	NUM
admet-1570	55	34	557	557	NUM
admet-1570	55	35	alkaline	alkaline	NOUN
admet-1570	55	36	phosphatase	phosphatase	NOUN
admet-1570	55	37	human	human	ADJ
admet-1570	55	38	recap	recap	NOUN
admet-1570	55	39	*	*	PROPN
admet-1570	55	40	*	*	SYM
admet-1570	55	41	140,000	140,000	NUM
admet-1570	55	42	liver	liver	NOUN
admet-1570	55	43	1100	1100	NUM
admet-1570	55	44	*	*	SYM
admet-1570	55	45	8770	8770	NUM
admet-1570	55	46	3859	3859	NUM
admet-1570	55	47	4182	4182	NUM
admet-1570	55	48	557	557	NUM
admet-1570	55	49	placental	placental	NOUN
admet-1570	55	50	140,000	140,000	NUM
admet-1570	55	51	liver	liver	NOUN
admet-1570	55	52	7537	7537	NUM
admet-1570	55	53	8770	8770	NUM
admet-1570	55	54	3859	3859	NUM
admet-1570	55	55	4182	4182	NUM
admet-1570	55	56	557	557	NUM
admet-1570	55	57	amylase	amylase	NOUN
admet-1570	55	58	baboon	baboon	NOUN
admet-1570	55	59	57,086	57,086	NUM
admet-1570	55	60	kidney	kidney	NOUN
admet-1570	55	61	100	100	NUM
admet-1570	55	62	4385	4385	NUM
admet-1570	55	63	1929	1929	NUM
admet-1570	55	64	4182	4182	NUM
admet-1570	55	65	557	557	NUM
admet-1570	55	66	lipase	lipase	NOUN
admet-1570	55	67	baboon	baboon	NOUN
admet-1570	55	68	48000	48000	NUM
admet-1570	55	69	kidney	kidney	NOUN
admet-1570	55	70	100	100	NUM
admet-1570	55	71	4385	4385	NUM
admet-1570	55	72	1929	1929	NUM
admet-1570	55	73	4182	4182	NUM
admet-1570	55	74	557	557	NUM
admet-1570	55	75	alanine	alanine	NOUN
admet-1570	55	76	transaminase	transaminase	NOUN
admet-1570	55	77	dog	dog	NOUN
admet-1570	55	78	54,600	54,600	NUM
admet-1570	55	79	sinusoidal	sinusoidal	NOUN
admet-1570	55	80	2949	2949	NUM
admet-1570	55	81	4385	4385	NUM
admet-1570	55	82	1929	1929	NUM
admet-1570	55	83	2323	2323	NUM
admet-1570	55	84	310	310	NUM
admet-1570	55	85	aspartate	aspartate	NOUN
admet-1570	55	86	aminotransferase	aminotransferase	NOUN
admet-1570	55	87	dog	dog	NOUN
admet-1570	55	88	mitochondrial	mitochondrial	ADJ
admet-1570	55	89	47,517	47,517	NUM
admet-1570	55	90	kupffer	kupffer	NOUN
admet-1570	55	91	49.1	49.1	NUM
admet-1570	55	92	4385	4385	NUM
admet-1570	55	93	1929	1929	NUM
admet-1570	55	94	2323	2323	NUM
admet-1570	55	95	310	310	NUM
admet-1570	55	96	cytoplasmic	cytoplasmic	ADJ
admet-1570	55	97	46,247	46,247	NUM
admet-1570	55	98	sinusoidal	sinusoidal	NOUN
admet-1570	55	99	689	689	NUM
admet-1570	55	100	4385	4385	NUM
admet-1570	55	101	1929	1929	NUM
admet-1570	55	102	2323	2323	NUM
admet-1570	55	103	310	310	NUM
admet-1570	55	104	creatine	creatine	PROPN
admet-1570	55	105	kinase	kinase	PROPN
admet-1570	55	106	dog	dog	NOUN
admet-1570	55	107	81,000	81,000	NUM
admet-1570	55	108	kupffer	kupffer	NOUN
admet-1570	55	109	88.1	88.1	NUM
admet-1570	55	110	6265	6265	NUM
admet-1570	55	111	2756	2756	NUM
admet-1570	55	112	2323	2323	NUM
admet-1570	55	113	310	310	NUM
admet-1570	55	114	lactate	lactate	NOUN
admet-1570	55	115	dehydrogenase	dehydrogenase	NOUN
admet-1570	55	116	lamb	lamb	PROPN
admet-1570	55	117	ld1	ld1	PROPN
admet-1570	55	118	heart	heart	NOUN
admet-1570	55	119	138,000	138,000	NUM
admet-1570	55	120	sinusoidal	sinusoidal	NOUN
admet-1570	55	121	2871	2871	NUM
admet-1570	55	122	1370	1370	NUM
admet-1570	55	123	3859	3859	NUM
admet-1570	55	124	726	726	NUM
admet-1570	55	125	619	619	NUM
admet-1570	55	126	ld5	ld5	NOUN
admet-1570	55	127	skeletal	skeletal	ADJ
admet-1570	55	128	muscle	muscle	NOUN
admet-1570	55	129	138,000	138,000	NUM
admet-1570	55	130	kupffer	kupffer	NOUN
admet-1570	55	131	440	440	NUM
admet-1570	55	132	1370	1370	NUM
admet-1570	55	133	3859	3859	NUM
admet-1570	55	134	726	726	NUM
admet-1570	55	135	619	619	NUM
admet-1570	55	136	albumin	albumin	ADJ
admet-1570	55	137	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	55	138	:	:	PUNCT
admet-1570	55	139	compartmental	compartmental	ADJ
admet-1570	55	140	and	and	CCONJ
admet-1570	55	141	physiological	physiological	ADJ
admet-1570	55	142	modeling	model	VERB
admet-1570	55	143	the	the	DET
admet-1570	55	144	distribution	distribution	NOUN
admet-1570	55	145	and	and	CCONJ
admet-1570	55	146	catabolism	catabolism	NOUN
admet-1570	55	147	of	of	ADP
admet-1570	55	148	albumin	albumin	NOUN
admet-1570	55	149	has	have	AUX
admet-1570	55	150	been	be	AUX
admet-1570	55	151	extensively	extensively	ADV
admet-1570	55	152	studied	study	VERB
admet-1570	55	153	and	and	CCONJ
admet-1570	55	154	will	will	AUX
admet-1570	55	155	serve	serve	VERB
admet-1570	55	156	as	as	ADP
admet-1570	55	157	our	our	PRON
admet-1570	55	158	basis	basis	NOUN
admet-1570	55	159	for	for	ADP
admet-1570	55	160	developing	develop	VERB
admet-1570	55	161	the	the	DET
admet-1570	55	162	compartmental	compartmental	ADJ
admet-1570	55	163	and	and	CCONJ
admet-1570	55	164	physiological	physiological	ADJ
admet-1570	55	165	models	model	NOUN
admet-1570	55	166	applied	apply	VERB
admet-1570	55	167	to	to	ADP
admet-1570	55	168	all	all	DET
admet-1570	55	169	the	the	DET
admet-1570	55	170	other	other	ADJ
admet-1570	55	171	proteins	protein	NOUN
admet-1570	55	172	.	.	PUNCT
admet-1570	56	1	albumin	albumin	ADJ
admet-1570	56	2	capillary	capillary	ADJ
admet-1570	56	3	permeability	permeability	NOUN
admet-1570	56	4	must	must	AUX
admet-1570	56	5	be	be	AUX
admet-1570	56	6	very	very	ADV
admet-1570	56	7	low	low	ADJ
admet-1570	56	8	in	in	ADP
admet-1570	56	9	order	order	NOUN
admet-1570	56	10	to	to	PART
admet-1570	56	11	preserve	preserve	VERB
admet-1570	56	12	the	the	DET
admet-1570	56	13	high	high	ADJ
admet-1570	56	14	plasma	plasma	NOUN
admet-1570	56	15	concentrations	concentration	NOUN
admet-1570	56	16	that	that	PRON
admet-1570	56	17	maintain	maintain	VERB
admet-1570	56	18	the	the	DET
admet-1570	56	19	colloidal	colloidal	NOUN
admet-1570	56	20	osmotic	osmotic	ADJ
admet-1570	56	21	pressure	pressure	NOUN
admet-1570	56	22	gradient	gradient	NOUN
admet-1570	56	23	between	between	ADP
admet-1570	56	24	plasma	plasma	NOUN
admet-1570	56	25	and	and	CCONJ
admet-1570	56	26	extravascular	extravascular	ADJ
admet-1570	56	27	fluid	fluid	NOUN
admet-1570	56	28	.	.	PUNCT
admet-1570	57	1	the	the	DET
admet-1570	57	2	permeability	permeability	NOUN
admet-1570	57	3	is	be	AUX
admet-1570	57	4	not	not	PART
admet-1570	57	5	zero	zero	NUM
admet-1570	57	6	,	,	PUNCT
admet-1570	57	7	however	however	ADV
admet-1570	57	8	,	,	PUNCT
admet-1570	57	9	and	and	CCONJ
admet-1570	57	10	lymph	lymph	NOUN
admet-1570	57	11	drainage	drainage	NOUN
admet-1570	57	12	of	of	ADP
admet-1570	57	13	the	the	DET
admet-1570	57	14	tissue	tissue	NOUN
admet-1570	57	15	space	space	NOUN
admet-1570	57	16	is	be	AUX
admet-1570	57	17	required	require	VERB
admet-1570	57	18	to	to	PART
admet-1570	57	19	maintain	maintain	VERB
admet-1570	57	20	this	this	DET
admet-1570	57	21	concentration	concentration	NOUN
admet-1570	57	22	gradient	gradient	NOUN
admet-1570	57	23	.	.	PUNCT
admet-1570	58	1	controversy	controversy	NOUN
admet-1570	58	2	exists	exist	VERB
admet-1570	58	3	concerning	concern	VERB
admet-1570	58	4	whether	whether	SCONJ
admet-1570	58	5	this	this	DET
admet-1570	58	6	slow	slow	ADJ
admet-1570	58	7	albumin	albumin	ADJ
admet-1570	58	8	leak	leak	NOUN
admet-1570	58	9	is	be	AUX
admet-1570	58	10	via	via	ADP
admet-1570	58	11	caveolar	caveolar	ADJ
admet-1570	58	12	vesicle	vesicle	NOUN
admet-1570	58	13	transport	transport	NOUN
admet-1570	58	14	versus	versus	ADP
admet-1570	58	15	through	through	ADP
admet-1570	58	16	fixed	fix	VERB
admet-1570	58	17	pores	pore	NOUN
admet-1570	58	18	or	or	CCONJ
admet-1570	58	19	tight	tight	ADJ
admet-1570	58	20	junctions	junction	NOUN
admet-1570	58	21	[	[	X
admet-1570	58	22	10	10	NUM
admet-1570	58	23	]	]	PUNCT
admet-1570	58	24	.	.	PUNCT
admet-1570	59	1	recent	recent	ADJ
admet-1570	59	2	results	result	NOUN
admet-1570	59	3	showing	show	VERB
admet-1570	59	4	that	that	SCONJ
admet-1570	59	5	mice	mouse	NOUN
admet-1570	59	6	lacking	lack	VERB
admet-1570	59	7	endothelial	endothelial	NOUN
admet-1570	59	8	caveolae	caveolae	NOUN
admet-1570	59	9	have	have	VERB
admet-1570	59	10	normal	normal	ADJ
admet-1570	59	11	capillary	capillary	ADJ
admet-1570	59	12	albumin	albumin	ADJ
admet-1570	59	13	permeability	permeability	NOUN
admet-1570	59	14	[	[	X
admet-1570	59	15	11	11	NUM
admet-1570	59	16	]	]	PUNCT
admet-1570	59	17	provide	provide	VERB
admet-1570	59	18	direct	direct	ADJ
admet-1570	59	19	support	support	NOUN
admet-1570	59	20	for	for	ADP
admet-1570	59	21	the	the	DET
admet-1570	59	22	pore	pore	ADJ
admet-1570	59	23	mechanism	mechanism	NOUN
admet-1570	59	24	.	.	PUNCT
admet-1570	60	1	in	in	ADP
admet-1570	60	2	addition	addition	NOUN
admet-1570	60	3	,	,	PUNCT
admet-1570	60	4	the	the	DET
admet-1570	60	5	proteins	protein	NOUN
admet-1570	60	6	leak	leak	NOUN
admet-1570	60	7	at	at	ADP
admet-1570	60	8	rates	rate	NOUN
admet-1570	60	9	are	be	AUX
admet-1570	60	10	roughly	roughly	ADV
admet-1570	60	11	inversely	inversely	ADV
admet-1570	60	12	proportional	proportional	ADJ
admet-1570	60	13	to	to	ADP
admet-1570	60	14	their	their	PRON
admet-1570	60	15	molecular	molecular	ADJ
admet-1570	60	16	radius	radius	NOUN
admet-1570	60	17	[	[	X
admet-1570	60	18	12	12	NUM
admet-1570	60	19	]	]	X
admet-1570	60	20	,	,	PUNCT
admet-1570	60	21	a	a	DET
admet-1570	60	22	characteristic	characteristic	NOUN
admet-1570	60	23	of	of	ADP
admet-1570	60	24	molecules	molecule	NOUN
admet-1570	60	25	passing	pass	VERB
admet-1570	60	26	through	through	ADP
admet-1570	60	27	pores	pore	NOUN
admet-1570	60	28	rather	rather	ADV
admet-1570	60	29	than	than	ADP
admet-1570	60	30	via	via	ADP
admet-1570	60	31	transcytotic	transcytotic	ADJ
admet-1570	60	32	vesicle	vesicle	NOUN
admet-1570	60	33	transport	transport	NOUN
admet-1570	60	34	.	.	PUNCT
admet-1570	61	1	an	an	DET
admet-1570	61	2	important	important	ADJ
admet-1570	61	3	question	question	NOUN
admet-1570	61	4	is	be	AUX
admet-1570	61	5	whether	whether	SCONJ
admet-1570	61	6	this	this	DET
admet-1570	61	7	albumin	albumin	ADJ
admet-1570	61	8	leak	leak	NOUN
admet-1570	61	9	represents	represent	VERB
admet-1570	61	10	a	a	DET
admet-1570	61	11	bidirectional	bidirectional	ADJ
admet-1570	61	12	diffusional	diffusional	ADJ
admet-1570	61	13	permeability	permeability	NOUN
admet-1570	61	14	versus	versus	ADP
admet-1570	61	15	a	a	DET
admet-1570	61	16	unidirectional	unidirectional	ADJ
admet-1570	61	17	convective	convective	ADJ
admet-1570	61	18	transport	transport	NOUN
admet-1570	61	19	from	from	ADP
admet-1570	61	20	the	the	DET
admet-1570	61	21	plasma	plasma	NOUN
admet-1570	61	22	to	to	ADP
admet-1570	61	23	the	the	DET
admet-1570	61	24	tissue	tissue	NOUN
admet-1570	61	25	and	and	CCONJ
admet-1570	61	26	return	return	VERB
admet-1570	61	27	via	via	ADP
admet-1570	61	28	lymph	lymph	NOUN
admet-1570	61	29	[	[	X
admet-1570	61	30	13,14	13,14	NUM
admet-1570	61	31	]	]	PUNCT
admet-1570	61	32	.	.	PUNCT
admet-1570	62	1	although	although	SCONJ
admet-1570	62	2	some	some	DET
admet-1570	62	3	quantitative	quantitative	ADJ
admet-1570	62	4	measurements	measurement	NOUN
admet-1570	62	5	of	of	ADP
admet-1570	62	6	simultaneous	simultaneous	ADJ
admet-1570	62	7	plasma	plasma	NOUN
admet-1570	62	8	and	and	CCONJ
admet-1570	62	9	lymph	lymph	NOUN
admet-1570	62	10	protein	protein	NOUN
admet-1570	62	11	pk	pk	NOUN
admet-1570	62	12	are	be	AUX
admet-1570	62	13	supportive	supportive	ADJ
admet-1570	62	14	of	of	ADP
admet-1570	62	15	the	the	DET
admet-1570	62	16	convection	convection	NOUN
admet-1570	62	17	mechanism	mechanism	NOUN
admet-1570	62	18	[	[	X
admet-1570	62	19	12,13,15	12,13,15	NUM
admet-1570	62	20	]	]	PUNCT
admet-1570	62	21	,	,	PUNCT
admet-1570	62	22	these	these	DET
admet-1570	62	23	results	result	NOUN
admet-1570	62	24	do	do	AUX
admet-1570	62	25	not	not	PART
admet-1570	62	26	rule	rule	VERB
admet-1570	62	27	out	out	ADP
admet-1570	62	28	a	a	DET
admet-1570	62	29	small	small	ADJ
admet-1570	62	30	diffusional	diffusional	ADJ
admet-1570	62	31	component	component	NOUN
admet-1570	62	32	.	.	PUNCT
admet-1570	63	1	it	it	PRON
admet-1570	63	2	is	be	AUX
admet-1570	63	3	assumed	assume	VERB
admet-1570	63	4	in	in	ADP
admet-1570	63	5	the	the	DET
admet-1570	63	6	most	most	ADV
admet-1570	63	7	recent	recent	ADJ
admet-1570	63	8	protein	protein	NOUN
admet-1570	63	9	modeling	model	VERB
admet-1570	63	10	that	that	SCONJ
admet-1570	63	11	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	63	12	d.g	d.g	PROPN
admet-1570	63	13	.	.	PROPN
admet-1570	63	14	levitt	levitt	PROPN
admet-1570	63	15	and	and	CCONJ
admet-1570	63	16	m.d	m.d	PROPN
admet-1570	63	17	.	.	PROPN
admet-1570	63	18	levitt	levitt	PROPN
admet-1570	63	19	admet	admet	PROPN
admet-1570	63	20	&	&	CCONJ
admet-1570	63	21	dmpk	dmpk	PROPN
admet-1570	63	22	11(1	11(1	NUM
admet-1570	63	23	)	)	PUNCT
admet-1570	63	24	(	(	PUNCT
admet-1570	63	25	2023	2023	NUM
admet-1570	63	26	)	)	PUNCT
admet-1570	63	27	57	57	NUM
admet-1570	63	28	-	-	SYM
admet-1570	63	29	80	80	NUM
admet-1570	63	30	60	60	NUM
admet-1570	63	31	the	the	DET
admet-1570	63	32	leak	leak	NOUN
admet-1570	63	33	is	be	AUX
admet-1570	63	34	entirely	entirely	ADV
admet-1570	63	35	convective	convective	ADJ
admet-1570	63	36	with	with	ADP
admet-1570	63	37	no	no	DET
admet-1570	63	38	significant	significant	ADJ
admet-1570	63	39	diffusional	diffusional	ADJ
admet-1570	63	40	component	component	NOUN
admet-1570	64	1	[	[	X
admet-1570	64	2	5,6,16	5,6,16	NUM
admet-1570	64	3	]	]	X
admet-1570	64	4	,	,	PUNCT
admet-1570	64	5	and	and	CCONJ
admet-1570	64	6	we	we	PRON
admet-1570	64	7	will	will	AUX
admet-1570	64	8	make	make	VERB
admet-1570	64	9	the	the	DET
admet-1570	64	10	same	same	ADJ
admet-1570	64	11	assumption	assumption	NOUN
admet-1570	64	12	.	.	PUNCT
admet-1570	65	1	table	table	NOUN
admet-1570	65	2	2	2	NUM
admet-1570	65	3	.	.	PUNCT
admet-1570	66	1	summary	summary	NOUN
admet-1570	66	2	of	of	ADP
admet-1570	66	3	protein	protein	NOUN
admet-1570	66	4	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	66	5	expressed	express	VERB
admet-1570	66	6	in	in	ADP
admet-1570	66	7	terms	term	NOUN
admet-1570	66	8	of	of	ADP
admet-1570	66	9	the	the	DET
admet-1570	66	10	lumped	lump	VERB
admet-1570	66	11	physiological	physiological	ADJ
admet-1570	66	12	parameters	parameter	NOUN
admet-1570	66	13	of	of	ADP
admet-1570	66	14	figure	figure	NOUN
admet-1570	66	15	1b	1b	NUM
admet-1570	66	16	:	:	PUNCT
admet-1570	66	17	plasma	plasma	NOUN
admet-1570	66	18	metabolic	metabolic	PROPN
admet-1570	66	19	clearance	clearance	NOUN
admet-1570	66	20	clp	clp	NOUN
admet-1570	66	21	,	,	PUNCT
admet-1570	66	22	filtration	filtration	NOUN
admet-1570	66	23	fractions	fraction	NOUN
admet-1570	66	24	f1	f1	NOUN
admet-1570	66	25	,	,	PUNCT
admet-1570	66	26	f2	f2	PROPN
admet-1570	66	27	,	,	PUNCT
admet-1570	66	28	and	and	CCONJ
admet-1570	66	29	lymph	lymph	NOUN
admet-1570	66	30	flows	flow	VERB
admet-1570	66	31	l1	l1	PROPN
admet-1570	66	32	l2	l2	PROPN
admet-1570	66	33	.	.	PUNCT
admet-1570	67	1	all	all	DET
admet-1570	67	2	results	result	NOUN
admet-1570	67	3	are	be	AUX
admet-1570	67	4	scaled	scale	VERB
admet-1570	67	5	to	to	ADP
admet-1570	67	6	a	a	DET
admet-1570	67	7	70	70	NUM
admet-1570	67	8	kg	kg	NOUN
admet-1570	67	9	human	human	ADJ
admet-1570	67	10	using	use	VERB
admet-1570	67	11	an	an	DET
admet-1570	67	12	assumed	assumed	ADJ
admet-1570	67	13	plasma	plasma	NOUN
admet-1570	67	14	volume	volume	NOUN
admet-1570	67	15	vp	vp	PROPN
admet-1570	67	16	=	=	SYM
admet-1570	67	17	2800	2800	NUM
admet-1570	67	18	ml	ml	NOUN
admet-1570	67	19	.	.	PUNCT
admet-1570	68	1	for	for	ADP
admet-1570	68	2	each	each	DET
admet-1570	68	3	species	specie	NOUN
admet-1570	68	4	,	,	PUNCT
admet-1570	68	5	the	the	DET
admet-1570	68	6	4	4	NUM
admet-1570	68	7	parameters	parameter	NOUN
admet-1570	68	8	l1	l1	PROPN
admet-1570	68	9	,	,	PUNCT
admet-1570	68	10	l2	l2	NOUN
admet-1570	68	11	,	,	PUNCT
admet-1570	68	12	v1	v1	NOUN
admet-1570	68	13	and	and	CCONJ
admet-1570	68	14	v2	v2	NOUN
admet-1570	68	15	are	be	AUX
admet-1570	68	16	adjusted	adjust	VERB
admet-1570	68	17	as	as	SCONJ
admet-1570	68	18	described	describe	VERB
admet-1570	68	19	and	and	CCONJ
admet-1570	68	20	assumed	assume	VERB
admet-1570	68	21	constant	constant	ADJ
admet-1570	68	22	for	for	ADP
admet-1570	68	23	all	all	DET
admet-1570	68	24	proteins	protein	NOUN
admet-1570	68	25	studied	study	VERB
admet-1570	68	26	in	in	ADP
admet-1570	68	27	that	that	DET
admet-1570	68	28	species	specie	NOUN
admet-1570	68	29	.	.	PUNCT
admet-1570	69	1	only	only	ADV
admet-1570	69	2	2	2	NUM
admet-1570	69	3	parameters	parameter	NOUN
admet-1570	69	4	are	be	AUX
admet-1570	69	5	adjusted	adjust	VERB
admet-1570	69	6	for	for	ADP
admet-1570	69	7	each	each	DET
admet-1570	69	8	protein	protein	NOUN
admet-1570	69	9	:	:	PUNCT
admet-1570	69	10	clp	clp	NOUN
admet-1570	69	11	and	and	CCONJ
admet-1570	69	12	f	f	PROPN
admet-1570	69	13	≈f1≈f2	≈f1≈f2	PROPN
admet-1570	69	14	.	.	PUNCT
admet-1570	70	1	for	for	ADP
admet-1570	70	2	human	human	NOUN
admet-1570	70	3	and	and	CCONJ
admet-1570	70	4	baboon	baboon	NOUN
admet-1570	70	5	:	:	PUNCT
admet-1570	70	6	v1	v1	PROPN
admet-1570	70	7	/	/	SYM
admet-1570	70	8	vp	vp	PROPN
admet-1570	70	9	=	=	NOUN
admet-1570	70	10	1.3	1.3	NUM
admet-1570	70	11	,	,	PUNCT
admet-1570	70	12	v2	v2	NOUN
admet-1570	70	13	/	/	SYM
admet-1570	70	14	vp=	vp=	NOUN
admet-1570	70	15	0.4	0.4	NUM
admet-1570	70	16	.	.	PUNCT
admet-1570	71	1	for	for	ADP
admet-1570	71	2	dog	dog	NOUN
admet-1570	71	3	and	and	CCONJ
admet-1570	71	4	lamb	lamb	PROPN
admet-1570	71	5	:	:	PUNCT
admet-1570	71	6	v1	v1	NOUN
admet-1570	71	7	/	/	SYM
admet-1570	71	8	vp	vp	PROPN
admet-1570	71	9	=	=	NOUN
admet-1570	71	10	1.0	1.0	NUM
admet-1570	71	11	,	,	PUNCT
admet-1570	71	12	v2	v2	PROPN
admet-1570	71	13	/	/	SYM
admet-1570	71	14	vp=	vp=	NOUN
admet-1570	71	15	0.3	0.3	NUM
admet-1570	71	16	.	.	PUNCT
admet-1570	72	1	“	"	PUNCT
admet-1570	72	2	kupffer	kupffer	NOUN
admet-1570	72	3	”	"	PUNCT
admet-1570	72	4	indicate	indicate	VERB
admet-1570	72	5	liver	liver	NOUN
admet-1570	72	6	kupffer	kupffer	NOUN
admet-1570	72	7	cells	cell	NOUN
admet-1570	72	8	and	and	CCONJ
admet-1570	72	9	“	"	PUNCT
admet-1570	72	10	sinusoidal	sinusoidal	NOUN
admet-1570	72	11	”	"	PUNCT
admet-1570	72	12	are	be	AUX
admet-1570	72	13	liver	liver	ADJ
admet-1570	72	14	parenchymal	parenchymal	ADJ
admet-1570	72	15	cells.(**a	cells.(**a	NOUN
admet-1570	72	16	pk	pk	NOUN
admet-1570	72	17	model	model	NOUN
admet-1570	72	18	with	with	ADP
admet-1570	72	19	an	an	DET
admet-1570	72	20	additional	additional	ADJ
admet-1570	72	21	liver	liver	NOUN
admet-1570	72	22	compartment	compartment	NOUN
admet-1570	72	23	is	be	AUX
admet-1570	72	24	used	use	VERB
admet-1570	72	25	for	for	ADP
admet-1570	72	26	recap	recap	NOUN
admet-1570	72	27	.	.	PUNCT
admet-1570	73	1	*	*	PUNCT
admet-1570	73	2	clp	clp	PROPN
admet-1570	73	3	for	for	ADP
admet-1570	73	4	recap	recap	NOUN
admet-1570	73	5	corresponds	correspond	NOUN
admet-1570	73	6	to	to	ADP
admet-1570	73	7	the	the	DET
admet-1570	73	8	liver	liver	NOUN
admet-1570	73	9	metabolic	metabolic	NOUN
admet-1570	73	10	clearance	clearance	NOUN
admet-1570	73	11	.	.	PUNCT
admet-1570	73	12	)	)	PUNCT
admet-1570	74	1	protein	protein	NOUN
admet-1570	74	2	species	specie	NOUN
admet-1570	74	3	mw	mw	VERB
admet-1570	74	4	catabolic	catabolic	ADJ
admet-1570	74	5	organ	organ	NOUN
admet-1570	74	6	clp	clp	NOUN
admet-1570	74	7	ml	ml	PROPN
admet-1570	74	8	/	/	SYM
admet-1570	74	9	m	m	PROPN
admet-1570	74	10	f1	f1	NOUN
admet-1570	74	11	f2	f2	PROPN
admet-1570	74	12	l1	l1	PROPN
admet-1570	74	13	ml	ml	PROPN
admet-1570	74	14	/	/	SYM
admet-1570	74	15	m	m	PROPN
admet-1570	74	16	l2	l2	NOUN
admet-1570	74	17	ml	ml	NOUN
admet-1570	74	18	/	/	SYM
admet-1570	74	19	m	m	PROPN
admet-1570	74	20	albumin	albumin	ADJ
admet-1570	74	21	human	human	ADJ
admet-1570	74	22	66,500	66,500	NUM
admet-1570	74	23	endothelium	endothelium	NOUN
admet-1570	74	24	0.167	0.167	NUM
admet-1570	74	25	0.734	0.734	NUM
admet-1570	74	26	0.722	0.722	NUM
admet-1570	74	27	0.87	0.87	NUM
admet-1570	74	28	2.00	2.00	NUM
admet-1570	74	29	monoclonal	monoclonal	NOUN
admet-1570	74	30	antibody	antibody	NOUN
admet-1570	74	31	human	human	ADJ
admet-1570	74	32	mepolizumab	mepolizumab	NOUN
admet-1570	74	33	149,000	149,000	NUM
admet-1570	74	34	endothelium	endothelium	NOUN
admet-1570	74	35	0.132	0.132	NUM
admet-1570	74	36	0.367	0.367	NUM
admet-1570	74	37	0.361	0.361	NUM
admet-1570	74	38	0.87	0.87	NUM
admet-1570	74	39	2.00	2.00	NUM
admet-1570	74	40	infliximab	infliximab	NOUN
admet-1570	74	41	149,000	149,000	NUM
admet-1570	74	42	endothelium	endothelium	NOUN
admet-1570	74	43	0.23	0.23	NUM
admet-1570	74	44	0.367	0.367	NUM
admet-1570	74	45	0.361	0.361	NUM
admet-1570	74	46	0.87	0.87	NUM
admet-1570	74	47	2.00	2.00	NUM
admet-1570	74	48	alkaline	alkaline	NOUN
admet-1570	74	49	phosphatase	phosphatase	NOUN
admet-1570	74	50	human	human	ADJ
admet-1570	74	51	recap	recap	NOUN
admet-1570	74	52	*	*	PROPN
admet-1570	74	53	*	*	SYM
admet-1570	74	54	140,000	140,000	NUM
admet-1570	74	55	liver	liver	NOUN
admet-1570	74	56	66.2	66.2	NUM
admet-1570	74	57	*	*	NUM
admet-1570	74	58	0.367	0.367	NUM
admet-1570	74	59	0.361	0.361	NUM
admet-1570	74	60	0.87	0.87	NUM
admet-1570	74	61	2.00	2.00	NUM
admet-1570	74	62	placental	placental	NOUN
admet-1570	74	63	140,000	140,000	NUM
admet-1570	74	64	liver	liver	NOUN
admet-1570	74	65	0.371	0.371	NUM
admet-1570	74	66	0.367	0.367	NUM
admet-1570	74	67	0.361	0.361	NUM
admet-1570	74	68	0.87	0.87	NUM
admet-1570	74	69	2.00	2.00	NUM
admet-1570	74	70	amylase	amylase	NOUN
admet-1570	74	71	baboon	baboon	NOUN
admet-1570	74	72	57,086	57,086	NUM
admet-1570	74	73	kidney	kidney	NOUN
admet-1570	74	74	27.9	27.9	NUM
admet-1570	74	75	0.734	0.734	NUM
admet-1570	74	76	0.722	0.722	NUM
admet-1570	74	77	0.87	0.87	NUM
admet-1570	74	78	2.00	2.00	NUM
admet-1570	74	79	lipase	lipase	NOUN
admet-1570	74	80	baboon	baboon	NOUN
admet-1570	74	81	48000	48000	NUM
admet-1570	74	82	kidney	kidney	PROPN
admet-1570	74	83	27.9	27.9	NUM
admet-1570	74	84	0.734	0.734	NUM
admet-1570	74	85	0.722	0.722	NUM
admet-1570	74	86	0.87	0.87	NUM
admet-1570	74	87	2.00	2.00	NUM
admet-1570	74	88	alanine	alanine	NOUN
admet-1570	74	89	transaminase	transaminase	NOUN
admet-1570	74	90	dog	dog	NOUN
admet-1570	74	91	54,600	54,600	NUM
admet-1570	74	92	sinusoidal	sinusoidal	NOUN
admet-1570	74	93	0.949	0.949	NUM
admet-1570	74	94	0.530	0.530	NUM
admet-1570	74	95	0.535	0.535	NUM
admet-1570	74	96	1.2	1.2	NUM
admet-1570	74	97	2.71	2.71	NUM
admet-1570	74	98	aspartate	aspartate	NOUN
admet-1570	74	99	aminotransferase	aminotransferase	NOUN
admet-1570	74	100	dog	dog	NOUN
admet-1570	74	101	mitochondrial	mitochondrial	ADJ
admet-1570	74	102	47,517	47,517	NUM
admet-1570	74	103	kupffer	kupffer	NOUN
admet-1570	74	104	56.9	56.9	NUM
admet-1570	74	105	0.530	0.530	NUM
admet-1570	74	106	0.535	0.535	NUM
admet-1570	74	107	1.2	1.2	NUM
admet-1570	74	108	2.71	2.71	NUM
admet-1570	74	109	cytoplasmic	cytoplasmic	ADJ
admet-1570	74	110	46,247	46,247	NUM
admet-1570	74	111	sinusoidal	sinusoidal	NOUN
admet-1570	74	112	4.06	4.06	NUM
admet-1570	74	113	0.530	0.530	NUM
admet-1570	74	114	0.535	0.535	NUM
admet-1570	74	115	1.2	1.2	NUM
admet-1570	74	116	2,71	2,71	NUM
admet-1570	74	117	creatine	creatine	PROPN
admet-1570	74	118	kinase	kinase	PROPN
admet-1570	74	119	dog	dog	NOUN
admet-1570	74	120	81,000	81,000	NUM
admet-1570	74	121	kupffer	kupffer	NOUN
admet-1570	74	122	31.7	31.7	NUM
admet-1570	74	123	0.370	0.370	NUM
admet-1570	74	124	0.374	0.374	NUM
admet-1570	74	125	1.2	1.2	NUM
admet-1570	74	126	2.71	2.71	NUM
admet-1570	74	127	lactate	lactate	NOUN
admet-1570	74	128	dehydrogenase	dehydrogenase	NOUN
admet-1570	74	129	lamb	lamb	PROPN
admet-1570	74	130	ld1	ld1	PROPN
admet-1570	74	131	heart	heart	NOUN
admet-1570	74	132	138,000	138,000	NUM
admet-1570	74	133	sinusoidal	sinusoidal	NOUN
admet-1570	74	134	0.975	0.975	NUM
admet-1570	74	135	0.53	0.53	NUM
admet-1570	74	136	0.53	0.53	NUM
admet-1570	74	137	3.85	3.85	NUM
admet-1570	74	138	1.35	1.35	NUM
admet-1570	74	139	ld5	ld5	NOUN
admet-1570	74	140	skeletal	skeletal	ADJ
admet-1570	74	141	muscle	muscle	NOUN
admet-1570	74	142	138,000	138,000	NUM
admet-1570	74	143	kupffer	kupffer	NOUN
admet-1570	74	144	6.35	6.35	NUM
admet-1570	74	145	0.53	0.53	NUM
admet-1570	74	146	0.53	0.53	NUM
admet-1570	74	147	3.85	3.85	NUM
admet-1570	74	148	1.35	1.35	NUM
admet-1570	74	149	figure	figure	NOUN
admet-1570	74	150	1	1	NUM
admet-1570	74	151	.	.	PUNCT
admet-1570	75	1	a	a	PRON
admet-1570	75	2	)	)	PUNCT
admet-1570	75	3	beeken	beeken	VERB
admet-1570	75	4	et	et	PROPN
admet-1570	75	5	al	al	PROPN
admet-1570	75	6	.	.	PROPN
admet-1570	75	7	steady	steady	ADJ
admet-1570	75	8	-	-	PUNCT
admet-1570	75	9	state	state	NOUN
admet-1570	75	10	kinetic	kinetic	ADJ
admet-1570	75	11	model	model	NOUN
admet-1570	75	12	.	.	PUNCT
admet-1570	76	1	b	b	X
admet-1570	76	2	)	)	PUNCT
admet-1570	76	3	interpretation	interpretation	NOUN
admet-1570	76	4	of	of	ADP
admet-1570	76	5	the	the	DET
admet-1570	76	6	model	model	NOUN
admet-1570	76	7	in	in	ADP
admet-1570	76	8	terms	term	NOUN
admet-1570	76	9	of	of	ADP
admet-1570	76	10	onedirectional	onedirectional	ADJ
admet-1570	76	11	convective	convective	ADJ
admet-1570	76	12	filtration	filtration	NOUN
admet-1570	76	13	from	from	ADP
admet-1570	76	14	plasma	plasma	NOUN
admet-1570	76	15	to	to	ADP
admet-1570	76	16	the	the	DET
admet-1570	76	17	tissue	tissue	NOUN
admet-1570	76	18	and	and	CCONJ
admet-1570	76	19	return	return	VERB
admet-1570	76	20	via	via	ADP
admet-1570	76	21	lymph	lymph	NOUN
admet-1570	76	22	flows	flow	VERB
admet-1570	76	23	to	to	ADP
admet-1570	76	24	the	the	DET
admet-1570	76	25	plasma	plasma	NOUN
admet-1570	76	26	.	.	PUNCT
admet-1570	77	1	beeken	beeken	VERB
admet-1570	77	2	et	et	PROPN
admet-1570	77	3	al	al	PROPN
admet-1570	77	4	.	.	PUNCT
admet-1570	78	1	[	[	X
admet-1570	78	2	3	3	X
admet-1570	78	3	]	]	PUNCT
admet-1570	78	4	and	and	CCONJ
admet-1570	78	5	takeda	takeda	PROPN
admet-1570	78	6	and	and	CCONJ
admet-1570	78	7	reeve	reeve	VERB
admet-1570	79	1	[	[	X
admet-1570	79	2	4	4	X
admet-1570	79	3	]	]	PUNCT
admet-1570	79	4	have	have	AUX
admet-1570	79	5	published	publish	VERB
admet-1570	79	6	similar	similar	ADJ
admet-1570	79	7	compartmental	compartmental	ADJ
admet-1570	79	8	pk	pk	PROPN
admet-1570	79	9	human	human	ADJ
admet-1570	79	10	albumin	albumin	NOUN
admet-1570	79	11	analyses	analysis	NOUN
admet-1570	79	12	using	use	VERB
admet-1570	79	13	the	the	DET
admet-1570	79	14	standard	standard	ADJ
admet-1570	79	15	3	3	NUM
admet-1570	79	16	-	-	PUNCT
admet-1570	79	17	compartment	compartment	NOUN
admet-1570	79	18	modeling	modeling	NOUN
admet-1570	79	19	approach	approach	NOUN
admet-1570	79	20	.	.	PUNCT
admet-1570	80	1	in	in	ADP
admet-1570	80	2	the	the	DET
admet-1570	80	3	model	model	NOUN
admet-1570	80	4	of	of	ADP
admet-1570	80	5	beeken	beeken	VERB
admet-1570	80	6	et	et	PROPN
admet-1570	80	7	al	al	PROPN
admet-1570	80	8	.	.	PROPN
admet-1570	80	9	diagramed	diagram	VERB
admet-1570	80	10	in	in	ADP
admet-1570	80	11	figure	figure	NOUN
admet-1570	80	12	1a	1a	NOUN
admet-1570	80	13	,	,	PUNCT
admet-1570	80	14	the	the	DET
admet-1570	80	15	plasma	plasma	NOUN
admet-1570	80	16	albumin	albumin	NOUN
admet-1570	80	17	exchanges	exchange	NOUN
admet-1570	80	18	with	with	ADP
admet-1570	80	19	two	two	NUM
admet-1570	80	20	tissue	tissue	NOUN
admet-1570	80	21	compartments	compartment	NOUN
admet-1570	80	22	and	and	CCONJ
admet-1570	80	23	the	the	DET
admet-1570	80	24	kinetics	kinetic	NOUN
admet-1570	80	25	are	be	AUX
admet-1570	80	26	characterized	characterize	VERB
admet-1570	80	27	admet	admet	PROPN
admet-1570	80	28	&	&	CCONJ
admet-1570	80	29	dmpk	dmpk	PROPN
admet-1570	80	30	11(1	11(1	NUM
admet-1570	80	31	)	)	PUNCT
admet-1570	80	32	(	(	PUNCT
admet-1570	80	33	2023	2023	NUM
admet-1570	80	34	)	)	PUNCT
admet-1570	80	35	57	57	NUM
admet-1570	80	36	-	-	SYM
admet-1570	80	37	80	80	NUM
admet-1570	80	38	protein	protein	NOUN
admet-1570	80	39	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	80	40	model	model	NOUN
admet-1570	80	41	doi	doi	NOUN
admet-1570	80	42	:	:	PUNCT
admet-1570	80	43	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	80	44	61	61	NUM
admet-1570	80	45	by	by	ADP
admet-1570	80	46	6	6	NUM
admet-1570	80	47	steady	steady	ADJ
admet-1570	80	48	state	state	NOUN
admet-1570	80	49	constants	constant	NOUN
admet-1570	80	50	:	:	PUNCT
admet-1570	80	51	m	m	PROPN
admet-1570	80	52	,	,	PUNCT
admet-1570	80	53	ap	ap	PROPN
admet-1570	80	54	,	,	PUNCT
admet-1570	80	55	a1	a1	PROPN
admet-1570	80	56	,	,	PUNCT
admet-1570	80	57	a2	a2	PROPN
admet-1570	80	58	,	,	PUNCT
admet-1570	80	59	r1	r1	NOUN
admet-1570	80	60	,	,	PUNCT
admet-1570	80	61	and	and	CCONJ
admet-1570	80	62	r2	r2	PROPN
admet-1570	80	63	.	.	PUNCT
admet-1570	81	1	in	in	ADP
admet-1570	81	2	the	the	DET
admet-1570	81	3	steady	steady	ADJ
admet-1570	81	4	state	state	NOUN
admet-1570	81	5	,	,	PUNCT
admet-1570	81	6	m	m	VERB
admet-1570	81	7	equals	equal	VERB
admet-1570	81	8	the	the	DET
admet-1570	81	9	rate	rate	NOUN
admet-1570	81	10	of	of	ADP
admet-1570	81	11	synthesis	synthesis	NOUN
admet-1570	81	12	which	which	PRON
admet-1570	81	13	equals	equal	VERB
admet-1570	81	14	rate	rate	NOUN
admet-1570	81	15	of	of	ADP
admet-1570	81	16	catabolism	catabolism	NOUN
admet-1570	81	17	,	,	PUNCT
admet-1570	81	18	ap	ap	PROPN
admet-1570	81	19	,	,	PUNCT
admet-1570	81	20	a1	a1	PROPN
admet-1570	81	21	,	,	PUNCT
admet-1570	81	22	and	and	CCONJ
admet-1570	81	23	a2	a2	PROPN
admet-1570	81	24	are	be	AUX
admet-1570	81	25	the	the	DET
admet-1570	81	26	amounts	amount	NOUN
admet-1570	81	27	in	in	ADP
admet-1570	81	28	each	each	DET
admet-1570	81	29	compartment	compartment	NOUN
admet-1570	81	30	and	and	CCONJ
admet-1570	81	31	r1	r1	PROPN
admet-1570	81	32	and	and	CCONJ
admet-1570	81	33	r2	r2	PROPN
admet-1570	81	34	are	be	AUX
admet-1570	81	35	the	the	DET
admet-1570	81	36	exchange	exchange	NOUN
admet-1570	81	37	rates	rate	NOUN
admet-1570	81	38	.	.	PUNCT
admet-1570	82	1	the	the	DET
admet-1570	82	2	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	82	3	of	of	ADP
admet-1570	82	4	proteins	protein	NOUN
admet-1570	82	5	has	have	VERB
admet-1570	82	6	the	the	DET
admet-1570	82	7	simplifying	simplify	VERB
admet-1570	82	8	characteristic	characteristic	ADJ
admet-1570	82	9	that	that	SCONJ
admet-1570	82	10	their	their	PRON
admet-1570	82	11	distribution	distribution	NOUN
admet-1570	82	12	is	be	AUX
admet-1570	82	13	limited	limit	VERB
admet-1570	82	14	primarily	primarily	ADV
admet-1570	82	15	to	to	ADP
admet-1570	82	16	the	the	DET
admet-1570	82	17	extracellular	extracellular	ADJ
admet-1570	82	18	space	space	NOUN
admet-1570	82	19	.	.	PUNCT
admet-1570	83	1	thus	thus	ADV
admet-1570	83	2	,	,	PUNCT
admet-1570	83	3	ap	ap	PROPN
admet-1570	83	4	is	be	AUX
admet-1570	83	5	the	the	DET
admet-1570	83	6	amount	amount	NOUN
admet-1570	83	7	in	in	ADP
admet-1570	83	8	the	the	DET
admet-1570	83	9	plasma	plasma	NOUN
admet-1570	83	10	volume	volume	NOUN
admet-1570	83	11	vp	vp	PROPN
admet-1570	83	12	and	and	CCONJ
admet-1570	83	13	the	the	DET
admet-1570	83	14	plasma	plasma	NOUN
admet-1570	83	15	albumin	albumin	NOUN
admet-1570	83	16	concentration	concentration	NOUN
admet-1570	83	17	is	be	AUX
admet-1570	83	18	cp	cp	INTJ
admet-1570	83	19	=	=	PUNCT
admet-1570	83	20	ap	ap	PROPN
admet-1570	83	21	/	/	SYM
admet-1570	83	22	vp	vp	PROPN
admet-1570	83	23	.	.	PUNCT
admet-1570	84	1	similarly	similarly	ADV
admet-1570	84	2	,	,	PUNCT
admet-1570	84	3	a1	a1	NOUN
admet-1570	84	4	and	and	CCONJ
admet-1570	84	5	a2	a2	PROPN
admet-1570	84	6	are	be	AUX
admet-1570	84	7	the	the	DET
admet-1570	84	8	amounts	amount	NOUN
admet-1570	84	9	in	in	ADP
admet-1570	84	10	the	the	DET
admet-1570	84	11	compartmental	compartmental	ADJ
admet-1570	84	12	interstitial	interstitial	ADJ
admet-1570	84	13	volumes	volume	NOUN
admet-1570	84	14	[	[	X
admet-1570	84	15	17	17	NUM
admet-1570	84	16	]	]	PUNCT
admet-1570	84	17	.	.	PUNCT
admet-1570	85	1	these	these	DET
admet-1570	85	2	6	6	NUM
admet-1570	85	3	parameters	parameter	NOUN
admet-1570	85	4	can	can	AUX
admet-1570	85	5	be	be	AUX
admet-1570	85	6	reduced	reduce	VERB
admet-1570	85	7	to	to	ADP
admet-1570	85	8	5	5	NUM
admet-1570	85	9	by	by	ADP
admet-1570	85	10	scaling	scale	VERB
admet-1570	85	11	them	they	PRON
admet-1570	85	12	to	to	ADP
admet-1570	85	13	the	the	DET
admet-1570	85	14	amount	amount	NOUN
admet-1570	85	15	in	in	ADP
admet-1570	85	16	plasma	plasma	NOUN
admet-1570	85	17	(	(	PUNCT
admet-1570	85	18	ap	ap	PROPN
admet-1570	85	19	)	)	PUNCT
admet-1570	85	20	and	and	CCONJ
admet-1570	85	21	expressing	express	VERB
admet-1570	85	22	them	they	PRON
admet-1570	85	23	in	in	ADP
admet-1570	85	24	terms	term	NOUN
admet-1570	85	25	of	of	ADP
admet-1570	85	26	the	the	DET
admet-1570	85	27	following	follow	VERB
admet-1570	85	28	five	five	NUM
admet-1570	85	29	time	time	NOUN
admet-1570	85	30	constants	constant	NOUN
admet-1570	85	31	(	(	PUNCT
admet-1570	85	32	in	in	ADP
admet-1570	85	33	units	unit	NOUN
admet-1570	85	34	of	of	ADP
admet-1570	85	35	minutes	minute	NOUN
admet-1570	85	36	):	):	PUNCT
admet-1570	85	37	p	p	X
admet-1570	85	38	p	p	X
admet-1570	85	39	p	p	NOUN
admet-1570	85	40	1	1	NUM
admet-1570	85	41	2	2	NUM
admet-1570	85	42	m	m	PROPN
admet-1570	85	43	p1	p1	NOUN
admet-1570	85	44	p2	p2	PROPN
admet-1570	85	45	t1	t1	NOUN
admet-1570	85	46	t2	t2	NOUN
admet-1570	85	47	1	1	NUM
admet-1570	85	48	2	2	NUM
admet-1570	85	49	1	1	NUM
admet-1570	85	50	2	2	NUM
admet-1570	85	51	a	a	PRON
admet-1570	85	52	a	a	DET
admet-1570	85	53	a	a	PRON
admet-1570	85	54	a	a	PRON
admet-1570	85	55	a	a	DET
admet-1570	85	56	t	t	NOUN
admet-1570	85	57	t	t	NOUN
admet-1570	85	58	t	t	PROPN
admet-1570	85	59	t	t	PROPN
admet-1570	85	60	t	t	PROPN
admet-1570	85	61	m	m	NOUN
admet-1570	85	62	r	r	NOUN
admet-1570	85	63	r	r	NOUN
admet-1570	85	64	r	r	NOUN
admet-1570	85	65	r	r	NOUN
admet-1570	85	66	(	(	PUNCT
admet-1570	85	67	1	1	NUM
admet-1570	85	68	)	)	PUNCT
admet-1570	85	69	in	in	ADP
admet-1570	85	70	the	the	DET
admet-1570	85	71	steady	steady	ADJ
admet-1570	85	72	state	state	NOUN
admet-1570	85	73	case	case	NOUN
admet-1570	85	74	,	,	PUNCT
admet-1570	85	75	when	when	SCONJ
admet-1570	85	76	albumin	albumin	NOUN
admet-1570	85	77	is	be	AUX
admet-1570	85	78	being	be	AUX
admet-1570	85	79	synthesized	synthesize	VERB
admet-1570	85	80	at	at	ADP
admet-1570	85	81	the	the	DET
admet-1570	85	82	same	same	ADJ
admet-1570	85	83	rate	rate	NOUN
admet-1570	85	84	that	that	PRON
admet-1570	85	85	it	it	PRON
admet-1570	85	86	is	be	AUX
admet-1570	85	87	removed	remove	VERB
admet-1570	85	88	by	by	ADP
admet-1570	85	89	catabolism	catabolism	NOUN
admet-1570	85	90	/	/	SYM
admet-1570	85	91	excretion	excretion	NOUN
admet-1570	85	92	,	,	PUNCT
admet-1570	85	93	tm	tm	PROPN
admet-1570	85	94	would	would	AUX
admet-1570	85	95	be	be	AUX
admet-1570	85	96	the	the	DET
admet-1570	85	97	time	time	NOUN
admet-1570	85	98	required	require	VERB
admet-1570	85	99	to	to	PART
admet-1570	85	100	catabolize	catabolize	VERB
admet-1570	85	101	/	/	SYM
admet-1570	85	102	excrete	excrete	VERB
admet-1570	85	103	the	the	DET
admet-1570	85	104	initial	initial	ADJ
admet-1570	85	105	amount	amount	NOUN
admet-1570	85	106	in	in	ADP
admet-1570	85	107	the	the	DET
admet-1570	85	108	plasma	plasma	NOUN
admet-1570	85	109	(=	(=	X
admet-1570	85	110	ap	ap	PROPN
admet-1570	85	111	)	)	PUNCT
admet-1570	85	112	.	.	PUNCT
admet-1570	86	1	in	in	ADP
admet-1570	86	2	the	the	DET
admet-1570	86	3	non	non	ADJ
admet-1570	86	4	-	-	ADJ
admet-1570	86	5	steady	steady	ADJ
admet-1570	86	6	state	state	NOUN
admet-1570	86	7	in	in	ADP
admet-1570	86	8	which	which	PRON
admet-1570	86	9	there	there	PRON
admet-1570	86	10	is	be	VERB
admet-1570	86	11	no	no	DET
admet-1570	86	12	new	new	ADJ
admet-1570	86	13	synthesis	synthesis	NOUN
admet-1570	86	14	of	of	ADP
admet-1570	86	15	albumin	albumin	NOUN
admet-1570	86	16	,	,	PUNCT
admet-1570	86	17	tm	tm	PROPN
admet-1570	86	18	is	be	AUX
admet-1570	86	19	the	the	DET
admet-1570	86	20	time	time	NOUN
admet-1570	86	21	for	for	SCONJ
admet-1570	86	22	catabolism	catabolism	NOUN
admet-1570	86	23	/	/	SYM
admet-1570	86	24	excretion	excretion	NOUN
admet-1570	86	25	to	to	PART
admet-1570	86	26	lower	lower	VERB
admet-1570	86	27	the	the	DET
admet-1570	86	28	blood	blood	NOUN
admet-1570	86	29	albumin	albumin	ADJ
admet-1570	86	30	concentration	concentration	NOUN
admet-1570	86	31	to	to	ADP
admet-1570	86	32	0.368	0.368	NUM
admet-1570	86	33	(=	(=	NOUN
admet-1570	86	34	1	1	NUM
admet-1570	86	35	/	/	SYM
admet-1570	86	36	e	e	NOUN
admet-1570	86	37	)	)	PUNCT
admet-1570	86	38	of	of	ADP
admet-1570	86	39	its	its	PRON
admet-1570	86	40	original	original	ADJ
admet-1570	86	41	concentration	concentration	NOUN
admet-1570	86	42	,	,	PUNCT
admet-1570	86	43	assuming	assume	VERB
admet-1570	86	44	no	no	DET
admet-1570	86	45	tissue	tissue	NOUN
admet-1570	86	46	exchange	exchange	NOUN
admet-1570	86	47	.	.	PUNCT
admet-1570	87	1	similarly	similarly	ADV
admet-1570	87	2	,	,	PUNCT
admet-1570	87	3	tp1	tp1	PROPN
admet-1570	87	4	and	and	CCONJ
admet-1570	87	5	tp2	tp2	PROPN
admet-1570	87	6	are	be	AUX
admet-1570	87	7	the	the	DET
admet-1570	87	8	time	time	NOUN
admet-1570	87	9	constants	constant	NOUN
admet-1570	87	10	for	for	ADP
admet-1570	87	11	the	the	DET
admet-1570	87	12	fall	fall	NOUN
admet-1570	87	13	in	in	ADP
admet-1570	87	14	plasma	plasma	NOUN
admet-1570	87	15	concentration	concentration	NOUN
admet-1570	87	16	produced	produce	VERB
admet-1570	87	17	by	by	ADP
admet-1570	87	18	filtration	filtration	NOUN
admet-1570	87	19	to	to	ADP
admet-1570	87	20	the	the	DET
admet-1570	87	21	tissue	tissue	NOUN
admet-1570	87	22	,	,	PUNCT
admet-1570	87	23	and	and	CCONJ
admet-1570	87	24	tt1	tt1	NOUN
admet-1570	87	25	and	and	CCONJ
admet-1570	87	26	tt2	tt2	PROPN
admet-1570	87	27	are	be	AUX
admet-1570	87	28	time	time	NOUN
admet-1570	87	29	constants	constant	NOUN
admet-1570	87	30	for	for	ADP
admet-1570	87	31	the	the	DET
admet-1570	87	32	washout	washout	NOUN
admet-1570	87	33	of	of	ADP
admet-1570	87	34	the	the	DET
admet-1570	87	35	tissue	tissue	NOUN
admet-1570	87	36	compartments	compartment	NOUN
admet-1570	87	37	.	.	PUNCT
admet-1570	88	1	all	all	DET
admet-1570	88	2	pk	pk	NOUN
admet-1570	88	3	results	result	NOUN
admet-1570	88	4	are	be	AUX
admet-1570	88	5	scaled	scale	VERB
admet-1570	88	6	to	to	ADP
admet-1570	88	7	the	the	DET
admet-1570	88	8	human	human	NOUN
admet-1570	88	9	with	with	ADP
admet-1570	88	10	an	an	DET
admet-1570	88	11	assumed	assumed	ADJ
admet-1570	88	12	plasma	plasma	NOUN
admet-1570	88	13	volume	volume	NOUN
admet-1570	88	14	of	of	ADP
admet-1570	88	15	2800	2800	NUM
admet-1570	88	16	ml	ml	NOUN
admet-1570	88	17	.	.	PUNCT
admet-1570	88	18	figure	figure	NOUN
admet-1570	88	19	2	2	NUM
admet-1570	88	20	.	.	PUNCT
admet-1570	88	21	comparison	comparison	NOUN
admet-1570	88	22	of	of	ADP
admet-1570	88	23	pk	pk	NOUN
admet-1570	88	24	compartmental	compartmental	ADJ
admet-1570	88	25	protein	protein	NOUN
admet-1570	88	26	model	model	NOUN
admet-1570	88	27	(	(	PUNCT
admet-1570	88	28	line	line	NOUN
admet-1570	88	29	)	)	PUNCT
admet-1570	88	30	for	for	ADP
admet-1570	88	31	bolus	bolus	NOUN
admet-1570	88	32	iv	iv	NUM
admet-1570	88	33	human	human	NOUN
admet-1570	88	34	i131	i131	PROPN
admet-1570	88	35	albumin	albumin	NOUN
admet-1570	88	36	versus	versus	ADP
admet-1570	88	37	experimental	experimental	ADJ
admet-1570	88	38	data	datum	NOUN
admet-1570	88	39	(	(	PUNCT
admet-1570	88	40	solid	solid	ADJ
admet-1570	88	41	circles	circle	NOUN
admet-1570	88	42	)	)	PUNCT
admet-1570	88	43	of	of	ADP
admet-1570	88	44	takeda	takeda	PROPN
admet-1570	88	45	and	and	CCONJ
admet-1570	88	46	reeve	reeve	PROPN
admet-1570	88	47	.	.	PUNCT
admet-1570	89	1	we	we	PRON
admet-1570	89	2	have	have	AUX
admet-1570	89	3	incorporated	incorporate	VERB
admet-1570	89	4	this	this	DET
admet-1570	89	5	compartmental	compartmental	ADJ
admet-1570	89	6	model	model	NOUN
admet-1570	89	7	into	into	ADP
admet-1570	89	8	a	a	DET
admet-1570	89	9	general	general	ADJ
admet-1570	89	10	computer	computer	NOUN
admet-1570	89	11	routine	routine	NOUN
admet-1570	89	12	using	use	VERB
admet-1570	89	13	maple	maple	NOUN
admet-1570	89	14	(	(	PUNCT
admet-1570	89	15	maplesoft	maplesoft	ADV
admet-1570	89	16	)	)	PUNCT
admet-1570	89	17	with	with	ADP
admet-1570	89	18	the	the	DET
admet-1570	89	19	6	6	NUM
admet-1570	89	20	parameters	parameter	NOUN
admet-1570	89	21	determined	determine	VERB
admet-1570	89	22	by	by	ADP
admet-1570	89	23	simple	simple	ADJ
admet-1570	89	24	trial	trial	NOUN
admet-1570	89	25	and	and	CCONJ
admet-1570	89	26	error	error	NOUN
admet-1570	89	27	adjustments	adjustment	NOUN
admet-1570	89	28	.	.	PUNCT
admet-1570	90	1	as	as	ADP
admet-1570	90	2	a	a	DET
admet-1570	90	3	test	test	NOUN
admet-1570	90	4	,	,	PUNCT
admet-1570	90	5	figure	figure	NOUN
admet-1570	90	6	2	2	NUM
admet-1570	90	7	shows	show	VERB
admet-1570	90	8	the	the	DET
admet-1570	90	9	good	good	ADJ
admet-1570	90	10	agreement	agreement	NOUN
admet-1570	90	11	of	of	ADP
admet-1570	90	12	the	the	DET
admet-1570	90	13	theoretical	theoretical	ADJ
admet-1570	90	14	results	result	NOUN
admet-1570	90	15	(	(	PUNCT
admet-1570	90	16	solid	solid	ADJ
admet-1570	90	17	line	line	NOUN
admet-1570	90	18	)	)	PUNCT
admet-1570	90	19	versus	versus	ADP
admet-1570	90	20	the	the	DET
admet-1570	90	21	independent	independent	ADJ
admet-1570	90	22	experimental	experimental	ADJ
admet-1570	90	23	data	datum	NOUN
admet-1570	90	24	of	of	ADP
admet-1570	90	25	takeda	takeda	PROPN
admet-1570	90	26	and	and	CCONJ
admet-1570	90	27	reeve	reeve	VERB
admet-1570	91	1	[	[	X
admet-1570	91	2	4	4	X
admet-1570	91	3	]	]	PUNCT
admet-1570	91	4	for	for	ADP
admet-1570	91	5	the	the	DET
admet-1570	91	6	time	time	NOUN
admet-1570	91	7	course	course	NOUN
admet-1570	91	8	of	of	ADP
admet-1570	91	9	plasma	plasma	NOUN
admet-1570	91	10	i131	i131	PROPN
admet-1570	91	11	-	-	PUNCT
admet-1570	91	12	albumin	albumin	NOUN
admet-1570	91	13	following	follow	VERB
admet-1570	91	14	a	a	DET
admet-1570	91	15	bolus	bolus	ADJ
admet-1570	91	16	input	input	NOUN
admet-1570	91	17	to	to	ADP
admet-1570	91	18	the	the	DET
admet-1570	91	19	plasma	plasma	NOUN
admet-1570	91	20	,	,	PUNCT
admet-1570	91	21	using	use	VERB
admet-1570	91	22	the	the	DET
admet-1570	91	23	rate	rate	NOUN
admet-1570	91	24	constants	constant	NOUN
admet-1570	91	25	listed	list	VERB
admet-1570	91	26	in	in	ADP
admet-1570	91	27	table	table	NOUN
admet-1570	91	28	1	1	NUM
admet-1570	91	29	,	,	PUNCT
admet-1570	91	30	differing	differ	VERB
admet-1570	91	31	by	by	ADP
admet-1570	91	32	only	only	ADV
admet-1570	91	33	a	a	DET
admet-1570	91	34	few	few	ADJ
admet-1570	91	35	percent	percent	NOUN
admet-1570	91	36	from	from	ADP
admet-1570	91	37	those	those	PRON
admet-1570	91	38	of	of	ADP
admet-1570	91	39	beeken	beeken	VERB
admet-1570	91	40	et	et	PROPN
admet-1570	91	41	al	al	PROPN
admet-1570	91	42	.	.	PUNCT
admet-1570	92	1	[	[	X
admet-1570	92	2	3	3	NUM
admet-1570	92	3	]	]	PUNCT
admet-1570	92	4	.	.	PUNCT
admet-1570	93	1	the	the	DET
admet-1570	93	2	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	93	3	d.g	d.g	PROPN
admet-1570	93	4	.	.	PROPN
admet-1570	93	5	levitt	levitt	PROPN
admet-1570	93	6	and	and	CCONJ
admet-1570	93	7	m.d	m.d	PROPN
admet-1570	93	8	.	.	PROPN
admet-1570	93	9	levitt	levitt	PROPN
admet-1570	93	10	admet	admet	PROPN
admet-1570	93	11	&	&	CCONJ
admet-1570	93	12	dmpk	dmpk	PROPN
admet-1570	93	13	11(1	11(1	NUM
admet-1570	93	14	)	)	PUNCT
admet-1570	93	15	(	(	PUNCT
admet-1570	93	16	2023	2023	NUM
admet-1570	93	17	)	)	PUNCT
admet-1570	93	18	57	57	NUM
admet-1570	93	19	-	-	SYM
admet-1570	93	20	80	80	NUM
admet-1570	93	21	62	62	NUM
admet-1570	93	22	metabolic	metabolic	NOUN
admet-1570	93	23	time	time	NOUN
admet-1570	93	24	constant	constant	ADJ
admet-1570	93	25	(	(	PUNCT
admet-1570	93	26	tm	tm	NOUN
admet-1570	93	27	)	)	PUNCT
admet-1570	93	28	is	be	AUX
admet-1570	93	29	16,750	16,750	NUM
admet-1570	93	30	minutes	minute	NOUN
admet-1570	93	31	(	(	PUNCT
admet-1570	93	32	11.6	11.6	NUM
admet-1570	93	33	days	day	NOUN
admet-1570	93	34	)	)	PUNCT
admet-1570	93	35	.	.	PUNCT
admet-1570	94	1	this	this	PRON
admet-1570	94	2	is	be	AUX
admet-1570	94	3	the	the	DET
admet-1570	94	4	hypothetical	hypothetical	ADJ
admet-1570	94	5	time	time	NOUN
admet-1570	94	6	constant	constant	ADJ
admet-1570	94	7	for	for	ADP
admet-1570	94	8	the	the	DET
admet-1570	94	9	exponential	exponential	ADJ
admet-1570	94	10	fall	fall	NOUN
admet-1570	94	11	in	in	ADP
admet-1570	94	12	the	the	DET
admet-1570	94	13	plasma	plasma	NOUN
admet-1570	94	14	concentration	concentration	NOUN
admet-1570	94	15	where	where	SCONJ
admet-1570	94	16	the	the	DET
admet-1570	94	17	plasma	plasma	NOUN
admet-1570	94	18	albumin	albumin	NOUN
admet-1570	94	19	does	do	AUX
admet-1570	94	20	not	not	PART
admet-1570	94	21	exchange	exchange	VERB
admet-1570	94	22	with	with	ADP
admet-1570	94	23	the	the	DET
admet-1570	94	24	tissue	tissue	NOUN
admet-1570	94	25	.	.	PUNCT
admet-1570	95	1	the	the	DET
admet-1570	95	2	actual	actual	ADJ
admet-1570	95	3	plasma	plasma	NOUN
admet-1570	95	4	pk	pk	NOUN
admet-1570	95	5	,	,	PUNCT
admet-1570	95	6	including	include	VERB
admet-1570	95	7	tissue	tissue	NOUN
admet-1570	95	8	exchange	exchange	NOUN
admet-1570	95	9	,	,	PUNCT
admet-1570	95	10	is	be	AUX
admet-1570	95	11	multi	multi	ADJ
admet-1570	95	12	-	-	ADJ
admet-1570	95	13	exponential	exponential	ADJ
admet-1570	95	14	and	and	CCONJ
admet-1570	95	15	,	,	PUNCT
admet-1570	95	16	therefore	therefore	ADV
admet-1570	95	17	,	,	PUNCT
admet-1570	95	18	can	can	AUX
admet-1570	95	19	not	not	PART
admet-1570	95	20	by	by	ADP
admet-1570	95	21	described	describe	VERB
admet-1570	95	22	by	by	ADP
admet-1570	95	23	a	a	DET
admet-1570	95	24	single	single	ADJ
admet-1570	95	25	time	time	NOUN
admet-1570	95	26	constant	constant	ADJ
admet-1570	95	27	.	.	PUNCT
admet-1570	96	1	however	however	ADV
admet-1570	96	2	,	,	PUNCT
admet-1570	96	3	because	because	SCONJ
admet-1570	96	4	tm	tm	PROPN
admet-1570	96	5	is	be	AUX
admet-1570	96	6	much	much	ADV
admet-1570	96	7	longer	long	ADJ
admet-1570	96	8	than	than	ADP
admet-1570	96	9	the	the	DET
admet-1570	96	10	other	other	ADJ
admet-1570	96	11	time	time	NOUN
admet-1570	96	12	constants	constant	NOUN
admet-1570	96	13	,	,	PUNCT
admet-1570	96	14	at	at	ADP
admet-1570	96	15	long	long	ADJ
admet-1570	96	16	times	time	NOUN
admet-1570	96	17	when	when	SCONJ
admet-1570	96	18	the	the	DET
admet-1570	96	19	plasma	plasma	NOUN
admet-1570	96	20	and	and	CCONJ
admet-1570	96	21	tissue	tissue	NOUN
admet-1570	96	22	are	be	AUX
admet-1570	96	23	approximately	approximately	ADV
admet-1570	96	24	equilibrated	equilibrate	VERB
admet-1570	96	25	the	the	DET
admet-1570	96	26	plasma	plasma	NOUN
admet-1570	96	27	pk	pk	NOUN
admet-1570	96	28	has	have	VERB
admet-1570	96	29	a	a	DET
admet-1570	96	30	time	time	NOUN
admet-1570	96	31	constant	constant	ADJ
admet-1570	96	32	equal	equal	ADJ
admet-1570	96	33	to	to	ADP
admet-1570	96	34	(	(	PUNCT
admet-1570	96	35	ap	ap	PROPN
admet-1570	97	1	+	+	CCONJ
admet-1570	97	2	a1	a1	NOUN
admet-1570	97	3	+	+	ADJ
admet-1570	97	4	a2)/m	a2)/m	NOUN
admet-1570	97	5	=	=	NOUN
admet-1570	97	6	tm(1+tt1	tm(1+tt1	NOUN
admet-1570	97	7	/	/	SYM
admet-1570	97	8	tp1+tt2	tp1+tt2	NOUN
admet-1570	97	9	/	/	SYM
admet-1570	97	10	tp2	tp2	PROPN
admet-1570	97	11	)	)	PUNCT
admet-1570	97	12	(	(	PUNCT
admet-1570	97	13	figure	figure	NOUN
admet-1570	97	14	1a	1a	NOUN
admet-1570	97	15	)	)	PUNCT
admet-1570	97	16	or	or	CCONJ
admet-1570	97	17	26	26	NUM
admet-1570	97	18	days	day	NOUN
admet-1570	97	19	.	.	PUNCT
admet-1570	98	1	the	the	DET
admet-1570	98	2	“	"	PUNCT
admet-1570	98	3	half	half	ADJ
admet-1570	98	4	-	-	PUNCT
admet-1570	98	5	time	time	NOUN
admet-1570	98	6	”	"	PUNCT
admet-1570	98	7	required	require	VERB
admet-1570	98	8	for	for	ADP
admet-1570	98	9	the	the	DET
admet-1570	98	10	plasma	plasma	NOUN
admet-1570	98	11	concentration	concentration	NOUN
admet-1570	98	12	to	to	PART
admet-1570	98	13	fall	fall	VERB
admet-1570	98	14	to	to	ADP
admet-1570	98	15	half	half	DET
admet-1570	98	16	its	its	PRON
admet-1570	98	17	initial	initial	ADJ
admet-1570	98	18	concentration	concentration	NOUN
admet-1570	98	19	is	be	AUX
admet-1570	98	20	only	only	ADV
admet-1570	98	21	about	about	ADV
admet-1570	98	22	2	2	NUM
admet-1570	98	23	days	day	NOUN
admet-1570	98	24	,	,	PUNCT
admet-1570	98	25	reflecting	reflect	VERB
admet-1570	98	26	primarily	primarily	ADV
admet-1570	98	27	the	the	DET
admet-1570	98	28	time	time	NOUN
admet-1570	98	29	constants	constant	NOUN
admet-1570	98	30	for	for	ADP
admet-1570	98	31	distribution	distribution	NOUN
admet-1570	98	32	to	to	ADP
admet-1570	98	33	the	the	DET
admet-1570	98	34	tissue	tissue	NOUN
admet-1570	98	35	(	(	PUNCT
admet-1570	98	36	tp1	tp1	NOUN
admet-1570	98	37	,	,	PUNCT
admet-1570	98	38	tp2	tp2	PROPN
admet-1570	98	39	)	)	PUNCT
admet-1570	98	40	.	.	PUNCT
admet-1570	99	1	for	for	ADP
admet-1570	99	2	pbpk	pbpk	NOUN
admet-1570	99	3	modeling	modeling	NOUN
admet-1570	99	4	,	,	PUNCT
admet-1570	99	5	it	it	PRON
admet-1570	99	6	is	be	AUX
admet-1570	99	7	necessary	necessary	ADJ
admet-1570	99	8	to	to	PART
admet-1570	99	9	specify	specify	VERB
admet-1570	99	10	the	the	DET
admet-1570	99	11	physiological	physiological	ADJ
admet-1570	99	12	parameters	parameter	NOUN
admet-1570	99	13	that	that	PRON
admet-1570	99	14	determine	determine	VERB
admet-1570	99	15	the	the	DET
admet-1570	99	16	protein	protein	NOUN
admet-1570	99	17	pk	pk	NOUN
admet-1570	99	18	(	(	PUNCT
admet-1570	99	19	flow	flow	NOUN
admet-1570	99	20	,	,	PUNCT
admet-1570	99	21	convective	convective	ADJ
admet-1570	99	22	transport	transport	NOUN
admet-1570	99	23	,	,	PUNCT
admet-1570	99	24	lymph	lymph	NOUN
admet-1570	99	25	flow	flow	NOUN
admet-1570	99	26	,	,	PUNCT
admet-1570	99	27	tissue	tissue	NOUN
admet-1570	99	28	volumes	volume	NOUN
admet-1570	99	29	,	,	PUNCT
admet-1570	99	30	etc	etc	X
admet-1570	99	31	.	.	X
admet-1570	99	32	)	)	PUNCT
admet-1570	100	1	for	for	ADP
admet-1570	100	2	each	each	DET
admet-1570	100	3	organ	organ	NOUN
admet-1570	100	4	.	.	PUNCT
admet-1570	101	1	the	the	DET
admet-1570	101	2	obvious	obvious	ADJ
admet-1570	101	3	difficulty	difficulty	NOUN
admet-1570	101	4	with	with	ADP
admet-1570	101	5	this	this	DET
admet-1570	101	6	approach	approach	NOUN
admet-1570	101	7	is	be	AUX
admet-1570	101	8	the	the	DET
admet-1570	101	9	huge	huge	ADJ
admet-1570	101	10	number	number	NOUN
admet-1570	101	11	of	of	ADP
admet-1570	101	12	model	model	NOUN
admet-1570	101	13	parameters	parameter	NOUN
admet-1570	101	14	,	,	PUNCT
admet-1570	101	15	most	most	ADJ
admet-1570	101	16	of	of	ADP
admet-1570	101	17	which	which	PRON
admet-1570	101	18	can	can	AUX
admet-1570	101	19	not	not	PART
admet-1570	101	20	be	be	AUX
admet-1570	101	21	directly	directly	ADV
admet-1570	101	22	determined	determine	VERB
admet-1570	101	23	.	.	PUNCT
admet-1570	102	1	for	for	ADP
admet-1570	102	2	example	example	NOUN
admet-1570	102	3	,	,	PUNCT
admet-1570	102	4	in	in	ADP
admet-1570	102	5	the	the	DET
admet-1570	102	6	rat	rat	NOUN
admet-1570	102	7	model	model	NOUN
admet-1570	102	8	of	of	ADP
admet-1570	102	9	shah	shah	PROPN
admet-1570	102	10	and	and	CCONJ
admet-1570	102	11	betts	betts	PROPN
admet-1570	102	12	[	[	PUNCT
admet-1570	102	13	6	6	NUM
admet-1570	102	14	]	]	PUNCT
admet-1570	102	15	,	,	PUNCT
admet-1570	102	16	there	there	PRON
admet-1570	102	17	are	be	VERB
admet-1570	102	18	16	16	NUM
admet-1570	102	19	organs	organ	NOUN
admet-1570	102	20	,	,	PUNCT
admet-1570	102	21	each	each	PRON
admet-1570	102	22	described	describe	VERB
admet-1570	102	23	by	by	ADP
admet-1570	102	24	5	5	NUM
admet-1570	102	25	or	or	CCONJ
admet-1570	102	26	more	more	ADJ
admet-1570	102	27	parameters	parameter	NOUN
admet-1570	102	28	,	,	PUNCT
admet-1570	102	29	for	for	ADP
admet-1570	102	30	a	a	DET
admet-1570	102	31	total	total	NOUN
admet-1570	102	32	of	of	ADP
admet-1570	102	33	90	90	NUM
admet-1570	102	34	parameters	parameter	NOUN
admet-1570	102	35	.	.	PUNCT
admet-1570	103	1	pbpk	pbpk	NOUN
admet-1570	103	2	modeling	modeling	NOUN
admet-1570	103	3	has	have	AUX
admet-1570	103	4	been	be	AUX
admet-1570	103	5	primarily	primarily	ADV
admet-1570	103	6	useful	useful	ADJ
admet-1570	103	7	for	for	ADP
admet-1570	103	8	some	some	DET
admet-1570	103	9	small	small	ADJ
admet-1570	103	10	molecules	molecule	NOUN
admet-1570	103	11	for	for	ADP
admet-1570	103	12	which	which	PRON
admet-1570	103	13	the	the	DET
admet-1570	103	14	important	important	ADJ
admet-1570	103	15	parameters	parameter	NOUN
admet-1570	103	16	are	be	AUX
admet-1570	103	17	simply	simply	ADV
admet-1570	103	18	the	the	DET
admet-1570	103	19	organ	organ	NOUN
admet-1570	103	20	blood	blood	NOUN
admet-1570	103	21	flow	flow	NOUN
admet-1570	103	22	and	and	CCONJ
admet-1570	103	23	volume	volume	NOUN
admet-1570	103	24	,	,	PUNCT
admet-1570	103	25	along	along	ADP
admet-1570	103	26	with	with	ADP
admet-1570	103	27	some	some	DET
admet-1570	103	28	other	other	ADJ
admet-1570	103	29	parameters	parameter	NOUN
admet-1570	103	30	that	that	PRON
admet-1570	103	31	can	can	AUX
admet-1570	103	32	be	be	AUX
admet-1570	103	33	predetermined	predetermine	VERB
admet-1570	103	34	[	[	X
admet-1570	103	35	18,19	18,19	NUM
admet-1570	103	36	]	]	PUNCT
admet-1570	103	37	.	.	PUNCT
admet-1570	104	1	in	in	ADP
admet-1570	104	2	marked	mark	VERB
admet-1570	104	3	contrast	contrast	NOUN
admet-1570	104	4	,	,	PUNCT
admet-1570	104	5	protein	protein	NOUN
admet-1570	104	6	pk	pk	NOUN
admet-1570	104	7	depends	depend	VERB
admet-1570	104	8	on	on	ADP
admet-1570	104	9	organ	organ	NOUN
admet-1570	104	10	parameters	parameter	NOUN
admet-1570	104	11	such	such	ADJ
admet-1570	104	12	as	as	ADP
admet-1570	104	13	capillary	capillary	ADJ
admet-1570	104	14	convective	convective	ADJ
admet-1570	104	15	transport	transport	NOUN
admet-1570	104	16	,	,	PUNCT
admet-1570	104	17	lymph	lymph	NOUN
admet-1570	104	18	flow	flow	NOUN
admet-1570	104	19	and	and	CCONJ
admet-1570	104	20	the	the	DET
admet-1570	104	21	convective	convective	ADJ
admet-1570	104	22	sieving	sieve	VERB
admet-1570	104	23	factor	factor	NOUN
admet-1570	104	24	for	for	ADP
admet-1570	104	25	the	the	DET
admet-1570	104	26	protein	protein	NOUN
admet-1570	104	27	,	,	PUNCT
admet-1570	104	28	factors	factor	VERB
admet-1570	104	29	that	that	SCONJ
admet-1570	104	30	,	,	PUNCT
admet-1570	104	31	at	at	ADP
admet-1570	104	32	present	present	ADJ
admet-1570	104	33	,	,	PUNCT
admet-1570	104	34	can	can	AUX
admet-1570	104	35	not	not	PART
admet-1570	104	36	be	be	AUX
admet-1570	104	37	accurately	accurately	ADV
admet-1570	104	38	predetermined	predetermine	VERB
admet-1570	104	39	.	.	PUNCT
admet-1570	105	1	in	in	ADP
admet-1570	105	2	an	an	DET
admet-1570	105	3	animal	animal	NOUN
admet-1570	105	4	model	model	NOUN
admet-1570	105	5	such	such	ADJ
admet-1570	105	6	as	as	ADP
admet-1570	105	7	the	the	DET
admet-1570	105	8	rat	rat	NOUN
admet-1570	105	9	,	,	PUNCT
admet-1570	105	10	one	one	PRON
admet-1570	105	11	can	can	AUX
admet-1570	105	12	use	use	VERB
admet-1570	105	13	the	the	DET
admet-1570	105	14	individual	individual	ADJ
admet-1570	105	15	organ	organ	NOUN
admet-1570	105	16	tissue	tissue	NOUN
admet-1570	105	17	concentrations	concentration	NOUN
admet-1570	105	18	to	to	PART
admet-1570	105	19	put	put	VERB
admet-1570	105	20	some	some	DET
admet-1570	105	21	constraints	constraint	NOUN
admet-1570	105	22	on	on	ADP
admet-1570	105	23	these	these	DET
admet-1570	105	24	parameters	parameter	NOUN
admet-1570	105	25	[	[	X
admet-1570	105	26	6	6	NUM
admet-1570	105	27	]	]	PUNCT
admet-1570	105	28	,	,	PUNCT
admet-1570	105	29	but	but	CCONJ
admet-1570	105	30	most	most	ADJ
admet-1570	105	31	remain	remain	VERB
admet-1570	105	32	just	just	ADV
admet-1570	105	33	educated	educate	VERB
admet-1570	105	34	guesses	guess	NOUN
admet-1570	105	35	.	.	PUNCT
admet-1570	106	1	for	for	ADP
admet-1570	106	2	the	the	DET
admet-1570	106	3	human	human	ADJ
admet-1570	106	4	,	,	PUNCT
admet-1570	106	5	tissue	tissue	NOUN
admet-1570	106	6	measurements	measurement	NOUN
admet-1570	106	7	are	be	AUX
admet-1570	106	8	not	not	PART
admet-1570	106	9	possible	possible	ADJ
admet-1570	106	10	,	,	PUNCT
admet-1570	106	11	severely	severely	ADV
admet-1570	106	12	limiting	limit	VERB
admet-1570	106	13	the	the	DET
admet-1570	106	14	value	value	NOUN
admet-1570	106	15	of	of	ADP
admet-1570	106	16	a	a	DET
admet-1570	106	17	complete	complete	ADJ
admet-1570	106	18	pbpk	pbpk	ADJ
admet-1570	106	19	model	model	NOUN
admet-1570	106	20	.	.	PUNCT
admet-1570	107	1	instead	instead	ADV
admet-1570	107	2	,	,	PUNCT
admet-1570	107	3	we	we	PRON
admet-1570	107	4	have	have	AUX
admet-1570	107	5	developed	develop	VERB
admet-1570	107	6	the	the	DET
admet-1570	107	7	“	"	PUNCT
admet-1570	107	8	lumped	lump	VERB
admet-1570	107	9	physiological	physiological	ADJ
admet-1570	107	10	”	"	PUNCT
admet-1570	107	11	model	model	NOUN
admet-1570	107	12	shown	show	VERB
admet-1570	107	13	schematically	schematically	NOUN
admet-1570	107	14	in	in	ADP
admet-1570	107	15	figure	figure	NOUN
admet-1570	107	16	1b	1b	NUM
admet-1570	107	17	.	.	PUNCT
admet-1570	108	1	it	it	PRON
admet-1570	108	2	is	be	AUX
admet-1570	108	3	assumed	assume	VERB
admet-1570	108	4	that	that	SCONJ
admet-1570	108	5	the	the	DET
admet-1570	108	6	“	"	PUNCT
admet-1570	108	7	tissue	tissue	NOUN
admet-1570	108	8	1	1	NUM
admet-1570	108	9	”	"	PUNCT
admet-1570	108	10	compartment	compartment	NOUN
admet-1570	108	11	(	(	PUNCT
admet-1570	108	12	figure	figure	NOUN
admet-1570	108	13	1a	1a	NOUN
admet-1570	108	14	)	)	PUNCT
admet-1570	108	15	with	with	ADP
admet-1570	108	16	the	the	DET
admet-1570	108	17	slow	slow	ADJ
admet-1570	108	18	turnover	turnover	NOUN
admet-1570	108	19	time	time	NOUN
admet-1570	108	20	(	(	PUNCT
admet-1570	108	21	tt1	tt1	NOUN
admet-1570	108	22	,	,	PUNCT
admet-1570	108	23	table	table	NOUN
admet-1570	108	24	1	1	NUM
admet-1570	108	25	)	)	PUNCT
admet-1570	108	26	corresponds	correspond	VERB
admet-1570	108	27	to	to	ADP
admet-1570	108	28	the	the	DET
admet-1570	108	29	lumped	lump	VERB
admet-1570	108	30	tissues	tissue	NOUN
admet-1570	108	31	with	with	ADP
admet-1570	108	32	relatively	relatively	ADV
admet-1570	108	33	low	low	ADJ
admet-1570	108	34	lymph	lymph	NOUN
admet-1570	108	35	flow	flow	NOUN
admet-1570	108	36	(	(	PUNCT
admet-1570	108	37	e.g.	e.g.	ADV
admet-1570	108	38	,	,	PUNCT
admet-1570	108	39	skeletal	skeletal	ADJ
admet-1570	108	40	muscle	muscle	NOUN
admet-1570	108	41	,	,	PUNCT
admet-1570	108	42	skin	skin	NOUN
admet-1570	108	43	,	,	PUNCT
admet-1570	108	44	etc	etc	X
admet-1570	108	45	.	.	X
admet-1570	108	46	)	)	PUNCT
admet-1570	109	1	and	and	CCONJ
admet-1570	109	2	the	the	DET
admet-1570	109	3	high	high	ADJ
admet-1570	109	4	turnover	turnover	NOUN
admet-1570	109	5	compartment	compartment	NOUN
admet-1570	109	6	(	(	PUNCT
admet-1570	109	7	tissue	tissue	NOUN
admet-1570	109	8	2	2	NUM
admet-1570	109	9	,	,	PUNCT
admet-1570	109	10	tt2	tt2	NOUN
admet-1570	109	11	)	)	PUNCT
admet-1570	109	12	represents	represent	VERB
admet-1570	109	13	the	the	DET
admet-1570	109	14	high	high	ADJ
admet-1570	109	15	lymph	lymph	NOUN
admet-1570	109	16	flow	flow	NOUN
admet-1570	109	17	tissues	tissue	NOUN
admet-1570	109	18	(	(	PUNCT
admet-1570	109	19	e.g.	e.g.	ADV
admet-1570	109	20	,	,	PUNCT
admet-1570	109	21	gastrointestinal	gastrointestinal	ADJ
admet-1570	109	22	tract	tract	NOUN
admet-1570	109	23	)	)	PUNCT
admet-1570	109	24	.	.	PUNCT
admet-1570	110	1	there	there	PRON
admet-1570	110	2	are	be	VERB
admet-1570	110	3	unidirectional	unidirectional	ADJ
admet-1570	110	4	convectional	convectional	ADJ
admet-1570	110	5	volume	volume	NOUN
admet-1570	110	6	flows	flow	VERB
admet-1570	110	7	from	from	ADP
admet-1570	110	8	plasma	plasma	NOUN
admet-1570	110	9	to	to	ADP
admet-1570	110	10	each	each	DET
admet-1570	110	11	tissue	tissue	NOUN
admet-1570	110	12	space	space	NOUN
admet-1570	110	13	of	of	ADP
admet-1570	110	14	l1	l1	PROPN
admet-1570	110	15	and	and	CCONJ
admet-1570	110	16	l2	l2	NOUN
admet-1570	110	17	and	and	CCONJ
admet-1570	110	18	equal	equal	ADJ
admet-1570	110	19	lymph	lymph	NOUN
admet-1570	110	20	flows	flow	VERB
admet-1570	110	21	l1	l1	PROPN
admet-1570	110	22	and	and	CCONJ
admet-1570	110	23	l2	l2	NOUN
admet-1570	110	24	returning	return	VERB
admet-1570	110	25	to	to	ADP
admet-1570	110	26	the	the	DET
admet-1570	110	27	plasma	plasma	NOUN
admet-1570	110	28	.	.	PUNCT
admet-1570	111	1	in	in	ADP
admet-1570	111	2	the	the	DET
admet-1570	111	3	convective	convective	ADJ
admet-1570	111	4	flow	flow	NOUN
admet-1570	111	5	from	from	ADP
admet-1570	111	6	the	the	DET
admet-1570	111	7	plasma	plasma	NOUN
admet-1570	111	8	to	to	ADP
admet-1570	111	9	tissue	tissue	VERB
admet-1570	111	10	,	,	PUNCT
admet-1570	111	11	the	the	DET
admet-1570	111	12	protein	protein	NOUN
admet-1570	111	13	is	be	AUX
admet-1570	111	14	sieved	sieve	VERB
admet-1570	111	15	by	by	ADP
admet-1570	111	16	factors	factor	NOUN
admet-1570	111	17	of	of	ADP
admet-1570	111	18	f1	f1	NOUN
admet-1570	111	19	and	and	CCONJ
admet-1570	111	20	f2	f2	PROPN
admet-1570	111	21	,	,	PUNCT
admet-1570	111	22	so	so	SCONJ
admet-1570	111	23	that	that	SCONJ
admet-1570	111	24	the	the	DET
admet-1570	111	25	rate	rate	NOUN
admet-1570	111	26	of	of	ADP
admet-1570	111	27	transport	transport	NOUN
admet-1570	111	28	from	from	ADP
admet-1570	111	29	blood	blood	NOUN
admet-1570	111	30	to	to	ADP
admet-1570	111	31	tissue	tissue	NOUN
admet-1570	111	32	is	be	AUX
admet-1570	111	33	equal	equal	ADJ
admet-1570	111	34	to	to	ADP
admet-1570	111	35	fi	fi	PROPN
admet-1570	111	36	li	li	PROPN
admet-1570	111	37	cp	cp	PROPN
admet-1570	111	38	.	.	PUNCT
admet-1570	112	1	there	there	PRON
admet-1570	112	2	is	be	VERB
admet-1570	112	3	no	no	DET
admet-1570	112	4	sieving	sieving	NOUN
admet-1570	112	5	of	of	ADP
admet-1570	112	6	protein	protein	NOUN
admet-1570	112	7	in	in	ADP
admet-1570	112	8	the	the	DET
admet-1570	112	9	returning	return	VERB
admet-1570	112	10	lymph	lymph	NOUN
admet-1570	112	11	with	with	ADP
admet-1570	112	12	the	the	DET
admet-1570	112	13	lymph	lymph	NOUN
admet-1570	112	14	concentration	concentration	NOUN
admet-1570	112	15	equal	equal	ADJ
admet-1570	112	16	to	to	ADP
admet-1570	112	17	that	that	PRON
admet-1570	112	18	in	in	ADP
admet-1570	112	19	the	the	DET
admet-1570	112	20	tissue	tissue	NOUN
admet-1570	112	21	space	space	NOUN
admet-1570	112	22	so	so	SCONJ
admet-1570	112	23	the	the	DET
admet-1570	112	24	rate	rate	NOUN
admet-1570	112	25	of	of	ADP
admet-1570	112	26	return	return	NOUN
admet-1570	112	27	to	to	ADP
admet-1570	112	28	the	the	DET
admet-1570	112	29	blood	blood	NOUN
admet-1570	112	30	is	be	AUX
admet-1570	112	31	lici	lici	ADJ
admet-1570	112	32	.	.	PUNCT
admet-1570	113	1	d	d	PRON
admet-1570	113	2	is	be	AUX
admet-1570	113	3	the	the	DET
admet-1570	113	4	dose	dose	NOUN
admet-1570	113	5	into	into	ADP
admet-1570	113	6	the	the	DET
admet-1570	113	7	blood	blood	NOUN
admet-1570	113	8	compartment	compartment	NOUN
admet-1570	113	9	and	and	CCONJ
admet-1570	113	10	clp	clp	NOUN
admet-1570	113	11	is	be	AUX
admet-1570	113	12	the	the	DET
admet-1570	113	13	plasma	plasma	NOUN
admet-1570	113	14	metabolic	metabolic	NOUN
admet-1570	113	15	clearance	clearance	NOUN
admet-1570	113	16	(	(	PUNCT
admet-1570	113	17	in	in	ADP
admet-1570	113	18	units	unit	NOUN
admet-1570	113	19	of	of	ADP
admet-1570	113	20	ml	ml	NOUN
admet-1570	113	21	/	/	SYM
admet-1570	113	22	min	min	NOUN
admet-1570	113	23	)	)	PUNCT
admet-1570	113	24	.	.	PUNCT
admet-1570	114	1	the	the	DET
admet-1570	114	2	plasma	plasma	NOUN
admet-1570	114	3	protein	protein	NOUN
admet-1570	114	4	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	114	5	is	be	AUX
admet-1570	114	6	a	a	DET
admet-1570	114	7	function	function	NOUN
admet-1570	114	8	of	of	ADP
admet-1570	114	9	just	just	ADV
admet-1570	114	10	the	the	DET
admet-1570	114	11	5	5	NUM
admet-1570	114	12	compartmental	compartmental	ADJ
admet-1570	114	13	time	time	NOUN
admet-1570	114	14	constants	constant	NOUN
admet-1570	114	15	(	(	PUNCT
admet-1570	114	16	eq	eq	NOUN
admet-1570	114	17	.	.	NOUN
admet-1570	114	18	1	1	NUM
admet-1570	114	19	)	)	PUNCT
admet-1570	114	20	and	and	CCONJ
admet-1570	114	21	does	do	AUX
admet-1570	114	22	not	not	PART
admet-1570	114	23	depend	depend	VERB
admet-1570	114	24	on	on	ADP
admet-1570	114	25	how	how	SCONJ
admet-1570	114	26	they	they	PRON
admet-1570	114	27	are	be	AUX
admet-1570	114	28	interpreted	interpret	VERB
admet-1570	114	29	physiologically	physiologically	ADV
admet-1570	114	30	.	.	PUNCT
admet-1570	115	1	however	however	ADV
admet-1570	115	2	,	,	PUNCT
admet-1570	115	3	to	to	PART
admet-1570	115	4	also	also	ADV
admet-1570	115	5	model	model	VERB
admet-1570	115	6	the	the	DET
admet-1570	115	7	lymph	lymph	NOUN
admet-1570	115	8	flow	flow	NOUN
admet-1570	115	9	or	or	CCONJ
admet-1570	115	10	the	the	DET
admet-1570	115	11	lymph	lymph	NOUN
admet-1570	115	12	protein	protein	NOUN
admet-1570	115	13	concentration	concentration	NOUN
admet-1570	115	14	using	use	VERB
admet-1570	115	15	the	the	DET
admet-1570	115	16	lumped	lump	VERB
admet-1570	115	17	model	model	NOUN
admet-1570	115	18	(	(	PUNCT
admet-1570	115	19	figure	figure	NOUN
admet-1570	115	20	1b	1b	NUM
admet-1570	115	21	)	)	PUNCT
admet-1570	115	22	.	.	PUNCT
admet-1570	116	1	it	it	PRON
admet-1570	116	2	is	be	AUX
admet-1570	116	3	necessary	necessary	ADJ
admet-1570	116	4	to	to	PART
admet-1570	116	5	assume	assume	VERB
admet-1570	116	6	two	two	NUM
admet-1570	116	7	additional	additional	ADJ
admet-1570	116	8	variables	variable	NOUN
admet-1570	116	9	that	that	PRON
admet-1570	116	10	assign	assign	VERB
admet-1570	116	11	physical	physical	ADJ
admet-1570	116	12	volumes	volume	NOUN
admet-1570	116	13	to	to	ADP
admet-1570	116	14	the	the	DET
admet-1570	116	15	tissue	tissue	NOUN
admet-1570	116	16	compartments	compartment	NOUN
admet-1570	116	17	(	(	PUNCT
admet-1570	116	18	v1	v1	NOUN
admet-1570	116	19	,	,	PUNCT
admet-1570	116	20	v2	v2	PROPN
admet-1570	116	21	)	)	PUNCT
admet-1570	116	22	.	.	PUNCT
admet-1570	117	1	using	use	VERB
admet-1570	117	2	these	these	DET
admet-1570	117	3	volumes	volume	NOUN
admet-1570	117	4	,	,	PUNCT
admet-1570	117	5	the	the	DET
admet-1570	117	6	metabolic	metabolic	NOUN
admet-1570	117	7	plasma	plasma	NOUN
admet-1570	117	8	clearance	clearance	NOUN
admet-1570	117	9	(	(	PUNCT
admet-1570	117	10	clp	clp	NOUN
admet-1570	117	11	)	)	PUNCT
admet-1570	117	12	,	,	PUNCT
admet-1570	117	13	lymph	lymph	NOUN
admet-1570	117	14	flows	flow	VERB
admet-1570	117	15	(	(	PUNCT
admet-1570	117	16	l1	l1	PROPN
admet-1570	117	17	,	,	PUNCT
admet-1570	117	18	l2	l2	NOUN
admet-1570	117	19	)	)	PUNCT
admet-1570	117	20	and	and	CCONJ
admet-1570	117	21	sieving	sieve	VERB
admet-1570	117	22	factors	factor	NOUN
admet-1570	117	23	(	(	PUNCT
admet-1570	117	24	f1	f1	NOUN
admet-1570	117	25	,	,	PUNCT
admet-1570	117	26	f2	f2	PROPN
admet-1570	117	27	)	)	PUNCT
admet-1570	117	28	in	in	ADP
admet-1570	117	29	figure	figure	NOUN
admet-1570	117	30	1b	1b	NUM
admet-1570	117	31	can	can	AUX
admet-1570	117	32	be	be	AUX
admet-1570	117	33	expressed	express	VERB
admet-1570	117	34	as	as	ADP
admet-1570	117	35	functions	function	NOUN
admet-1570	117	36	of	of	ADP
admet-1570	117	37	the	the	DET
admet-1570	117	38	five	five	NUM
admet-1570	117	39	compartmental	compartmental	ADJ
admet-1570	117	40	time	time	NOUN
admet-1570	117	41	constants	constant	NOUN
admet-1570	117	42	:	:	PUNCT
admet-1570	118	1	p	p	NOUN
admet-1570	118	2	1	1	NUM
admet-1570	118	3	2	2	NUM
admet-1570	118	4	p	p	NOUN
admet-1570	118	5	1	1	NUM
admet-1570	118	6	2	2	NUM
admet-1570	118	7	m	m	NOUN
admet-1570	118	8	1	1	NUM
admet-1570	118	9	2	2	NUM
admet-1570	118	10	1	1	NUM
admet-1570	118	11	1	1	NUM
admet-1570	118	12	2	2	NUM
admet-1570	118	13	2	2	NUM
admet-1570	118	14	1	1	NUM
admet-1570	118	15	2	2	NUM
admet-1570	118	16	p	p	NOUN
admet-1570	118	17	p	p	X
admet-1570	118	18	t	t	NOUN
admet-1570	118	19	t	t	NOUN
admet-1570	118	20	p	p	X
admet-1570	118	21	p	p	X
admet-1570	118	22	v	v	NUM
admet-1570	118	23	v	v	NUM
admet-1570	118	24	vv	vv	ADP
admet-1570	118	25	v	v	NOUN
admet-1570	118	26	cl	cl	NOUN
admet-1570	118	27	l	l	NOUN
admet-1570	118	28	l	l	NOUN
admet-1570	119	1	f	f	X
admet-1570	119	2	f	f	PROPN
admet-1570	119	3	t	t	PROPN
admet-1570	119	4	t	t	PROPN
admet-1570	119	5	t	t	PROPN
admet-1570	119	6	l	l	PROPN
admet-1570	119	7	t	t	PROPN
admet-1570	119	8	l	l	PROPN
admet-1570	119	9	t	t	PROPN
admet-1570	119	10	(	(	PUNCT
admet-1570	119	11	2	2	NUM
admet-1570	119	12	)	)	PUNCT
admet-1570	119	13	alternatively	alternatively	ADV
admet-1570	119	14	,	,	PUNCT
admet-1570	119	15	if	if	SCONJ
admet-1570	119	16	the	the	DET
admet-1570	119	17	two	two	NUM
admet-1570	119	18	lymph	lymph	NOUN
admet-1570	119	19	flows	flow	NOUN
admet-1570	119	20	are	be	AUX
admet-1570	119	21	known	know	VERB
admet-1570	119	22	,	,	PUNCT
admet-1570	119	23	then	then	ADV
admet-1570	119	24	eq	eq	NOUN
admet-1570	119	25	.	.	PROPN
admet-1570	119	26	2	2	NUM
admet-1570	119	27	can	can	AUX
admet-1570	119	28	be	be	AUX
admet-1570	119	29	used	use	VERB
admet-1570	119	30	to	to	PART
admet-1570	119	31	calculate	calculate	VERB
admet-1570	119	32	the	the	DET
admet-1570	119	33	volumes	volume	NOUN
admet-1570	119	34	v1	v1	VERB
admet-1570	119	35	and	and	CCONJ
admet-1570	119	36	v2	v2	NOUN
admet-1570	119	37	,	,	PUNCT
admet-1570	119	38	given	give	VERB
admet-1570	119	39	tt1	tt1	NOUN
admet-1570	119	40	and	and	CCONJ
admet-1570	119	41	tt2	tt2	PROPN
admet-1570	119	42	.	.	PUNCT
admet-1570	120	1	the	the	DET
admet-1570	120	2	time	time	NOUN
admet-1570	120	3	dependence	dependence	NOUN
admet-1570	120	4	of	of	ADP
admet-1570	120	5	the	the	DET
admet-1570	120	6	concentration	concentration	NOUN
admet-1570	120	7	in	in	ADP
admet-1570	120	8	the	the	DET
admet-1570	120	9	plasma	plasma	NOUN
admet-1570	120	10	(	(	PUNCT
admet-1570	120	11	cp(t	cp(t	NOUN
admet-1570	120	12	)	)	PUNCT
admet-1570	120	13	)	)	PUNCT
admet-1570	120	14	and	and	CCONJ
admet-1570	120	15	the	the	DET
admet-1570	120	16	two	two	NUM
admet-1570	120	17	tissues	tissue	NOUN
admet-1570	120	18	(	(	PUNCT
admet-1570	120	19	c1(t	c1(t	NOUN
admet-1570	120	20	)	)	PUNCT
admet-1570	120	21	,	,	PUNCT
admet-1570	120	22	c2(t	c2(t	PROPN
admet-1570	120	23	)	)	PUNCT
admet-1570	120	24	)	)	PUNCT
admet-1570	120	25	is	be	AUX
admet-1570	120	26	described	describe	VERB
admet-1570	120	27	by	by	ADP
admet-1570	120	28	the	the	DET
admet-1570	120	29	3	3	NUM
admet-1570	120	30	coupled	couple	VERB
admet-1570	120	31	differential	differential	ADJ
admet-1570	120	32	equations	equation	NOUN
admet-1570	120	33	:	:	PUNCT
admet-1570	120	34	admet	admet	PROPN
admet-1570	120	35	&	&	CCONJ
admet-1570	120	36	dmpk	dmpk	PROPN
admet-1570	120	37	11(1	11(1	NUM
admet-1570	120	38	)	)	PUNCT
admet-1570	120	39	(	(	PUNCT
admet-1570	120	40	2023	2023	NUM
admet-1570	120	41	)	)	PUNCT
admet-1570	120	42	57	57	NUM
admet-1570	120	43	-	-	SYM
admet-1570	120	44	80	80	NUM
admet-1570	120	45	protein	protein	NOUN
admet-1570	120	46	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	120	47	model	model	NOUN
admet-1570	120	48	doi	doi	PROPN
admet-1570	120	49	:	:	PUNCT
admet-1570	120	50	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	120	51	63	63	NUM
admet-1570	120	52	1	1	NUM
admet-1570	120	53	1	1	NUM
admet-1570	120	54	2	2	NUM
admet-1570	120	55	2	2	NUM
admet-1570	120	56	1	1	NUM
admet-1570	120	57	1	1	NUM
admet-1570	120	58	2	2	NUM
admet-1570	120	59	2	2	NUM
admet-1570	120	60	1	1	NUM
admet-1570	120	61	1	1	NUM
admet-1570	120	62	1	1	NUM
admet-1570	120	63	1	1	NUM
admet-1570	120	64	1	1	NUM
admet-1570	120	65	1	1	NUM
admet-1570	120	66	2	2	NUM
admet-1570	120	67	2	2	NUM
admet-1570	120	68	2	2	NUM
admet-1570	120	69	2	2	NUM
admet-1570	120	70	2	2	NUM
admet-1570	120	71	2	2	NUM
admet-1570	120	72	d	d	NOUN
admet-1570	120	73	(	(	PUNCT
admet-1570	120	74	)	)	PUNCT
admet-1570	120	75	(	(	PUNCT
admet-1570	120	76	)	)	PUNCT
admet-1570	120	77	(	(	PUNCT
admet-1570	120	78	)	)	PUNCT
admet-1570	120	79	(	(	PUNCT
admet-1570	120	80	)	)	PUNCT
admet-1570	120	81	(	(	PUNCT
admet-1570	120	82	)	)	PUNCT
admet-1570	120	83	(	(	PUNCT
admet-1570	120	84	)	)	PUNCT
admet-1570	120	85	d	d	NOUN
admet-1570	120	86	(	(	PUNCT
admet-1570	120	87	)	)	PUNCT
admet-1570	120	88	(	(	PUNCT
admet-1570	120	89	)	)	PUNCT
admet-1570	120	90	(	(	PUNCT
admet-1570	120	91	)	)	PUNCT
admet-1570	120	92	(	(	PUNCT
admet-1570	120	93	)	)	PUNCT
admet-1570	120	94	(	(	PUNCT
admet-1570	120	95	)	)	PUNCT
admet-1570	120	96	(	(	PUNCT
admet-1570	120	97	)	)	PUNCT
admet-1570	121	1	p	p	X
admet-1570	121	2	p	p	X
admet-1570	122	1	p	p	X
admet-1570	122	2	p	p	PROPN
admet-1570	122	3	p	p	PROPN
admet-1570	122	4	p	p	PROPN
admet-1570	122	5	p	p	X
admet-1570	122	6	c	c	PROPN
admet-1570	122	7	t	t	NOUN
admet-1570	122	8	v	v	NOUN
admet-1570	122	9	cl	cl	NOUN
admet-1570	122	10	c	c	NOUN
admet-1570	122	11	t	t	NOUN
admet-1570	123	1	f	f	PROPN
admet-1570	123	2	l	l	NOUN
admet-1570	123	3	f	f	X
admet-1570	124	1	l	l	NOUN
admet-1570	124	2	c	c	NOUN
admet-1570	125	1	t	t	PROPN
admet-1570	125	2	l	l	NOUN
admet-1570	125	3	c	c	NOUN
admet-1570	125	4	t	t	PROPN
admet-1570	125	5	l	l	NOUN
admet-1570	125	6	c	c	NOUN
admet-1570	125	7	t	t	PROPN
admet-1570	125	8	t	t	PROPN
admet-1570	125	9	dc	dc	PROPN
admet-1570	125	10	t	t	PROPN
admet-1570	125	11	v	v	NUM
admet-1570	126	1	l	l	NOUN
admet-1570	126	2	c	c	NOUN
admet-1570	127	1	t	t	NOUN
admet-1570	127	2	f	f	PROPN
admet-1570	128	1	l	l	NOUN
admet-1570	128	2	c	c	NOUN
admet-1570	129	1	t	t	X
admet-1570	129	2	dt	dt	X
admet-1570	129	3	dc	dc	PROPN
admet-1570	129	4	t	t	PROPN
admet-1570	129	5	v	v	NUM
admet-1570	129	6	l	l	NOUN
admet-1570	129	7	c	c	NOUN
admet-1570	130	1	t	t	NOUN
admet-1570	130	2	f	f	PROPN
admet-1570	130	3	l	l	NOUN
admet-1570	130	4	c	c	NOUN
admet-1570	130	5	t	t	X
admet-1570	130	6	dt	dt	X
admet-1570	130	7	(	(	PUNCT
admet-1570	130	8	3	3	X
admet-1570	130	9	)	)	PUNCT
admet-1570	130	10	the	the	DET
admet-1570	130	11	advantage	advantage	NOUN
admet-1570	130	12	of	of	ADP
admet-1570	130	13	the	the	DET
admet-1570	130	14	lumped	lump	VERB
admet-1570	130	15	physiological	physiological	ADJ
admet-1570	130	16	model	model	NOUN
admet-1570	130	17	(	(	PUNCT
admet-1570	130	18	figure	figure	NOUN
admet-1570	130	19	1b	1b	NUM
admet-1570	130	20	)	)	PUNCT
admet-1570	130	21	is	be	AUX
admet-1570	130	22	that	that	SCONJ
admet-1570	130	23	it	it	PRON
admet-1570	130	24	places	place	VERB
admet-1570	130	25	major	major	ADJ
admet-1570	130	26	physiological	physiological	ADJ
admet-1570	130	27	limitations	limitation	NOUN
admet-1570	130	28	on	on	ADP
admet-1570	130	29	the	the	DET
admet-1570	130	30	model	model	NOUN
admet-1570	130	31	parameters	parameter	NOUN
admet-1570	130	32	,	,	PUNCT
admet-1570	130	33	i.e.	i.e.	X
admet-1570	130	34	,	,	PUNCT
admet-1570	130	35	there	there	PRON
admet-1570	130	36	is	be	VERB
admet-1570	130	37	not	not	PART
admet-1570	130	38	a	a	DET
admet-1570	130	39	near	near	ADV
admet-1570	130	40	-	-	PUNCT
admet-1570	130	41	infinite	infinite	ADJ
admet-1570	130	42	number	number	NOUN
admet-1570	130	43	of	of	ADP
admet-1570	130	44	manipulations	manipulation	NOUN
admet-1570	130	45	that	that	PRON
admet-1570	130	46	can	can	AUX
admet-1570	130	47	be	be	AUX
admet-1570	130	48	employed	employ	VERB
admet-1570	130	49	to	to	PART
admet-1570	130	50	make	make	VERB
admet-1570	130	51	the	the	DET
admet-1570	130	52	model	model	NOUN
admet-1570	130	53	fit	fit	VERB
admet-1570	130	54	the	the	DET
admet-1570	130	55	data	datum	NOUN
admet-1570	130	56	.	.	PUNCT
admet-1570	131	1	in	in	ADP
admet-1570	131	2	our	our	PRON
admet-1570	131	3	fitting	fitting	NOUN
admet-1570	131	4	of	of	ADP
admet-1570	131	5	the	the	DET
admet-1570	131	6	data	datum	NOUN
admet-1570	131	7	,	,	PUNCT
admet-1570	131	8	we	we	PRON
admet-1570	131	9	have	have	AUX
admet-1570	131	10	made	make	VERB
admet-1570	131	11	the	the	DET
admet-1570	131	12	following	follow	VERB
admet-1570	131	13	assumptions	assumption	NOUN
admet-1570	131	14	:	:	PUNCT
admet-1570	131	15	1	1	X
admet-1570	131	16	)	)	PUNCT
admet-1570	131	17	for	for	ADP
admet-1570	131	18	a	a	DET
admet-1570	131	19	given	give	VERB
admet-1570	131	20	species	specie	NOUN
admet-1570	131	21	(	(	PUNCT
admet-1570	131	22	e.g.	e.g.	ADV
admet-1570	131	23	,	,	PUNCT
admet-1570	131	24	human	human	ADJ
admet-1570	131	25	,	,	PUNCT
admet-1570	131	26	dog	dog	NOUN
admet-1570	131	27	,	,	PUNCT
admet-1570	131	28	etc	etc	X
admet-1570	131	29	.	.	X
admet-1570	131	30	)	)	PUNCT
admet-1570	131	31	,	,	PUNCT
admet-1570	131	32	the	the	DET
admet-1570	131	33	value	value	NOUN
admet-1570	131	34	of	of	ADP
admet-1570	131	35	the	the	DET
admet-1570	131	36	lymph	lymph	NOUN
admet-1570	131	37	flows	flow	VERB
admet-1570	131	38	l1	l1	PROPN
admet-1570	131	39	and	and	CCONJ
admet-1570	131	40	l2	l2	NOUN
admet-1570	131	41	and	and	CCONJ
admet-1570	131	42	tissue	tissue	NOUN
admet-1570	131	43	volumes	volume	NOUN
admet-1570	131	44	v1	v1	VERB
admet-1570	131	45	and	and	CCONJ
admet-1570	131	46	v2	v2	PROPN
admet-1570	131	47	must	must	AUX
admet-1570	131	48	be	be	AUX
admet-1570	131	49	the	the	DET
admet-1570	131	50	same	same	ADJ
admet-1570	131	51	for	for	ADP
admet-1570	131	52	all	all	DET
admet-1570	131	53	proteins	protein	NOUN
admet-1570	131	54	studied	study	VERB
admet-1570	131	55	in	in	ADP
admet-1570	131	56	that	that	DET
admet-1570	131	57	species	specie	NOUN
admet-1570	131	58	.	.	PUNCT
admet-1570	132	1	2	2	X
admet-1570	132	2	)	)	PUNCT
admet-1570	132	3	the	the	DET
admet-1570	132	4	capillary	capillary	ADJ
admet-1570	132	5	filtration	filtration	NOUN
admet-1570	132	6	“	"	PUNCT
admet-1570	132	7	pore	pore	NOUN
admet-1570	132	8	”	"	PUNCT
admet-1570	132	9	must	must	AUX
admet-1570	132	10	be	be	AUX
admet-1570	132	11	roughly	roughly	ADV
admet-1570	132	12	the	the	DET
admet-1570	132	13	same	same	ADJ
admet-1570	132	14	for	for	ADP
admet-1570	132	15	the	the	DET
admet-1570	132	16	two	two	NUM
admet-1570	132	17	tissue	tissue	NOUN
admet-1570	132	18	regions	region	NOUN
admet-1570	132	19	,	,	PUNCT
admet-1570	132	20	implying	imply	VERB
admet-1570	132	21	the	the	DET
admet-1570	132	22	sieving	sieve	VERB
admet-1570	132	23	factor	factor	NOUN
admet-1570	132	24	f1	f1	NOUN
admet-1570	132	25	≈	≈	PROPN
admet-1570	132	26	f2	f2	PROPN
admet-1570	132	27	.	.	PUNCT
admet-1570	133	1	3	3	X
admet-1570	133	2	)	)	PUNCT
admet-1570	133	3	the	the	DET
admet-1570	133	4	values	value	NOUN
admet-1570	133	5	of	of	ADP
admet-1570	133	6	f	f	PROPN
admet-1570	133	7	must	must	AUX
admet-1570	133	8	be	be	AUX
admet-1570	133	9	physiologically	physiologically	ADV
admet-1570	133	10	reasonable	reasonable	ADJ
admet-1570	133	11	,	,	PUNCT
admet-1570	133	12	i.e.	i.e.	X
admet-1570	133	13	,	,	PUNCT
admet-1570	133	14	f	f	PROPN
admet-1570	133	15	must	must	AUX
admet-1570	133	16	be	be	AUX
admet-1570	133	17	<	<	X
admet-1570	133	18	=	=	X
admet-1570	133	19	1	1	NUM
admet-1570	133	20	and	and	CCONJ
admet-1570	133	21	,	,	PUNCT
admet-1570	133	22	for	for	ADP
admet-1570	133	23	a	a	DET
admet-1570	133	24	given	give	VERB
admet-1570	133	25	species	specie	NOUN
admet-1570	133	26	,	,	PUNCT
admet-1570	133	27	proteins	protein	NOUN
admet-1570	133	28	with	with	ADP
admet-1570	133	29	similar	similar	ADJ
admet-1570	133	30	molecular	molecular	ADJ
admet-1570	133	31	weights	weight	NOUN
admet-1570	133	32	should	should	AUX
admet-1570	133	33	have	have	VERB
admet-1570	133	34	similar	similar	ADJ
admet-1570	133	35	f	f	NOUN
admet-1570	133	36	,	,	PUNCT
admet-1570	133	37	and	and	CCONJ
admet-1570	133	38	f	f	PROPN
admet-1570	133	39	must	must	AUX
admet-1570	133	40	decrease	decrease	VERB
admet-1570	133	41	as	as	ADP
admet-1570	133	42	the	the	DET
admet-1570	133	43	protein	protein	NOUN
admet-1570	133	44	molecular	molecular	ADJ
admet-1570	133	45	weight	weight	NOUN
admet-1570	133	46	increases	increase	NOUN
admet-1570	133	47	.	.	PUNCT
admet-1570	134	1	these	these	DET
admet-1570	134	2	assumptions	assumption	NOUN
admet-1570	134	3	dramatically	dramatically	ADV
admet-1570	134	4	simplify	simplify	VERB
admet-1570	134	5	the	the	DET
admet-1570	134	6	model	model	NOUN
admet-1570	134	7	.	.	PUNCT
admet-1570	135	1	assuming	assume	VERB
admet-1570	135	2	that	that	SCONJ
admet-1570	135	3	l1	l1	PROPN
admet-1570	135	4	,	,	PUNCT
admet-1570	135	5	l2	l2	NOUN
admet-1570	135	6	,	,	PUNCT
admet-1570	135	7	v1	v1	VERB
admet-1570	135	8	and	and	CCONJ
admet-1570	135	9	v2	v2	PROPN
admet-1570	135	10	have	have	AUX
admet-1570	135	11	been	be	AUX
admet-1570	135	12	previously	previously	ADV
admet-1570	135	13	determined	determine	VERB
admet-1570	135	14	for	for	ADP
admet-1570	135	15	this	this	DET
admet-1570	135	16	species	specie	NOUN
admet-1570	135	17	,	,	PUNCT
admet-1570	135	18	in	in	ADP
admet-1570	135	19	place	place	NOUN
admet-1570	135	20	of	of	ADP
admet-1570	135	21	the	the	DET
admet-1570	135	22	5	5	NUM
admet-1570	135	23	adjustable	adjustable	ADJ
admet-1570	135	24	parameters	parameter	NOUN
admet-1570	135	25	in	in	ADP
admet-1570	135	26	the	the	DET
admet-1570	135	27	general	general	ADJ
admet-1570	135	28	model	model	NOUN
admet-1570	135	29	,	,	PUNCT
admet-1570	135	30	there	there	PRON
admet-1570	135	31	are	be	VERB
admet-1570	135	32	only	only	ADV
admet-1570	135	33	two	two	NUM
admet-1570	135	34	parameters	parameter	NOUN
admet-1570	135	35	that	that	PRON
admet-1570	135	36	can	can	AUX
admet-1570	135	37	be	be	AUX
admet-1570	135	38	adjusted	adjust	VERB
admet-1570	135	39	to	to	PART
admet-1570	135	40	fit	fit	VERB
admet-1570	135	41	different	different	ADJ
admet-1570	135	42	proteins	protein	NOUN
admet-1570	135	43	for	for	ADP
admet-1570	135	44	the	the	DET
admet-1570	135	45	same	same	ADJ
admet-1570	135	46	species	specie	NOUN
admet-1570	135	47	:	:	PUNCT
admet-1570	135	48	the	the	DET
admet-1570	135	49	plasma	plasma	NOUN
admet-1570	135	50	metabolic	metabolic	NOUN
admet-1570	135	51	clearance	clearance	NOUN
admet-1570	135	52	(	(	PUNCT
admet-1570	135	53	clp	clp	NOUN
admet-1570	135	54	)	)	PUNCT
admet-1570	135	55	and	and	CCONJ
admet-1570	135	56	the	the	DET
admet-1570	135	57	sieving	sieve	VERB
admet-1570	135	58	factor	factor	NOUN
admet-1570	135	59	(	(	PUNCT
admet-1570	135	60	≈f1	≈f1	NOUN
admet-1570	135	61	≈	≈	PROPN
admet-1570	135	62	f2	f2	PROPN
admet-1570	135	63	)	)	PUNCT
admet-1570	135	64	.	.	PUNCT
admet-1570	136	1	in	in	ADP
admet-1570	136	2	addition	addition	NOUN
admet-1570	136	3	,	,	PUNCT
admet-1570	136	4	for	for	ADP
admet-1570	136	5	a	a	DET
admet-1570	136	6	given	give	VERB
admet-1570	136	7	species	specie	NOUN
admet-1570	136	8	,	,	PUNCT
admet-1570	136	9	this	this	DET
admet-1570	136	10	sieving	sieve	VERB
admet-1570	136	11	factor	factor	NOUN
admet-1570	136	12	must	must	AUX
admet-1570	136	13	decrease	decrease	VERB
admet-1570	136	14	as	as	ADP
admet-1570	136	15	the	the	DET
admet-1570	136	16	protein	protein	NOUN
admet-1570	136	17	molecular	molecular	ADJ
admet-1570	136	18	weight	weight	NOUN
admet-1570	136	19	increases	increase	NOUN
admet-1570	136	20	.	.	PUNCT
admet-1570	137	1	as	as	SCONJ
admet-1570	137	2	shown	show	VERB
admet-1570	137	3	in	in	ADP
admet-1570	137	4	table	table	NOUN
admet-1570	137	5	2	2	NUM
admet-1570	137	6	,	,	PUNCT
admet-1570	137	7	we	we	PRON
admet-1570	137	8	have	have	AUX
admet-1570	137	9	been	be	AUX
admet-1570	137	10	able	able	ADJ
admet-1570	137	11	to	to	PART
admet-1570	137	12	successfully	successfully	ADV
admet-1570	137	13	fit	fit	VERB
admet-1570	137	14	the	the	DET
admet-1570	137	15	pk	pk	NOUN
admet-1570	137	16	data	datum	NOUN
admet-1570	137	17	for	for	ADP
admet-1570	137	18	the	the	DET
admet-1570	137	19	13	13	NUM
admet-1570	137	20	investigated	investigate	VERB
admet-1570	137	21	proteins	protein	NOUN
admet-1570	137	22	using	use	VERB
admet-1570	137	23	these	these	DET
admet-1570	137	24	constraints	constraint	NOUN
admet-1570	137	25	on	on	ADP
admet-1570	137	26	the	the	DET
admet-1570	137	27	model	model	NOUN
admet-1570	137	28	parameters	parameter	NOUN
admet-1570	137	29	.	.	PUNCT
admet-1570	138	1	the	the	DET
admet-1570	138	2	most	most	ADV
admet-1570	138	3	questionable	questionable	ADJ
admet-1570	138	4	of	of	ADP
admet-1570	138	5	these	these	DET
admet-1570	138	6	assumptions	assumption	NOUN
admet-1570	138	7	is	be	AUX
admet-1570	138	8	the	the	DET
admet-1570	138	9	assumption	assumption	NOUN
admet-1570	138	10	that	that	SCONJ
admet-1570	138	11	f1	f1	PROPN
admet-1570	138	12	≈	≈	PROPN
admet-1570	138	13	f2	f2	PROPN
admet-1570	138	14	.	.	PUNCT
admet-1570	139	1	zhao	zhao	PROPN
admet-1570	139	2	et	et	PROPN
admet-1570	139	3	al	al	PROPN
admet-1570	139	4	.	.	PUNCT
admet-1570	140	1	[	[	X
admet-1570	140	2	16	16	NUM
admet-1570	140	3	]	]	PUNCT
admet-1570	140	4	have	have	AUX
admet-1570	140	5	used	use	VERB
admet-1570	140	6	a	a	DET
admet-1570	140	7	similar	similar	ADJ
admet-1570	140	8	two	two	NUM
admet-1570	140	9	-	-	PUNCT
admet-1570	140	10	compartment	compartment	NOUN
admet-1570	140	11	convective	convective	ADJ
admet-1570	140	12	model	model	NOUN
admet-1570	140	13	to	to	PART
admet-1570	140	14	describe	describe	VERB
admet-1570	140	15	the	the	DET
admet-1570	140	16	plasma	plasma	NOUN
admet-1570	140	17	pk	pk	NOUN
admet-1570	140	18	of	of	ADP
admet-1570	140	19	a	a	DET
admet-1570	140	20	variety	variety	NOUN
admet-1570	140	21	of	of	ADP
admet-1570	140	22	monoclonal	monoclonal	NOUN
admet-1570	140	23	antibodies	antibody	NOUN
admet-1570	140	24	in	in	ADP
admet-1570	140	25	8	8	NUM
admet-1570	140	26	different	different	ADJ
admet-1570	140	27	animal	animal	NOUN
admet-1570	140	28	species	specie	NOUN
admet-1570	140	29	.	.	PUNCT
admet-1570	141	1	they	they	PRON
admet-1570	141	2	assumed	assume	VERB
admet-1570	141	3	that	that	SCONJ
admet-1570	141	4	compartment	compartment	NOUN
admet-1570	141	5	1	1	NUM
admet-1570	141	6	is	be	AUX
admet-1570	141	7	“	"	PUNCT
admet-1570	141	8	leaky	leaky	ADJ
admet-1570	141	9	”	"	PUNCT
admet-1570	141	10	with	with	ADP
admet-1570	141	11	a	a	DET
admet-1570	141	12	sieving	sieve	VERB
admet-1570	141	13	coefficient	coefficient	NOUN
admet-1570	141	14	f	f	PROPN
admet-1570	141	15	near	near	ADP
admet-1570	141	16	1	1	NUM
admet-1570	141	17	,	,	PUNCT
admet-1570	141	18	and	and	CCONJ
admet-1570	141	19	compartment	compartment	NOUN
admet-1570	141	20	2	2	NUM
admet-1570	141	21	is	be	AUX
admet-1570	141	22	“	"	PUNCT
admet-1570	141	23	tight	tight	ADJ
admet-1570	141	24	”	"	PUNCT
admet-1570	141	25	with	with	ADP
admet-1570	141	26	an	an	DET
admet-1570	141	27	f	f	NOUN
admet-1570	141	28	near	near	ADP
admet-1570	141	29	0	0	NUM
admet-1570	141	30	.	.	PUNCT
admet-1570	142	1	the	the	DET
admet-1570	142	2	primary	primary	ADJ
admet-1570	142	3	reason	reason	NOUN
admet-1570	142	4	for	for	ADP
admet-1570	142	5	this	this	DET
admet-1570	142	6	choice	choice	NOUN
admet-1570	142	7	is	be	AUX
admet-1570	142	8	to	to	PART
admet-1570	142	9	account	account	VERB
admet-1570	142	10	for	for	ADP
admet-1570	142	11	the	the	DET
admet-1570	142	12	liver	liver	NOUN
admet-1570	142	13	,	,	PUNCT
admet-1570	142	14	whose	whose	DET
admet-1570	142	15	sinusoids	sinusoid	NOUN
admet-1570	142	16	are	be	AUX
admet-1570	142	17	highly	highly	ADV
admet-1570	142	18	permeable	permeable	ADJ
admet-1570	142	19	(	(	PUNCT
admet-1570	142	20	“	"	PUNCT
admet-1570	142	21	leaky	leaky	ADJ
admet-1570	142	22	”	"	PUNCT
admet-1570	142	23	)	)	PUNCT
admet-1570	142	24	for	for	ADP
admet-1570	142	25	most	most	ADJ
admet-1570	142	26	proteins	protein	NOUN
admet-1570	142	27	.	.	PUNCT
admet-1570	143	1	we	we	PRON
admet-1570	143	2	disagree	disagree	VERB
admet-1570	143	3	with	with	ADP
admet-1570	143	4	this	this	DET
admet-1570	143	5	approach	approach	NOUN
admet-1570	143	6	.	.	PUNCT
admet-1570	144	1	the	the	DET
admet-1570	144	2	liver	liver	NOUN
admet-1570	144	3	sinusoids	sinusoid	NOUN
admet-1570	144	4	are	be	AUX
admet-1570	144	5	so	so	ADV
admet-1570	144	6	highly	highly	ADV
admet-1570	144	7	permeable	permeable	ADJ
admet-1570	144	8	that	that	SCONJ
admet-1570	144	9	the	the	DET
admet-1570	144	10	exchange	exchange	NOUN
admet-1570	144	11	of	of	ADP
admet-1570	144	12	albumin	albumin	NOUN
admet-1570	144	13	between	between	ADP
admet-1570	144	14	the	the	DET
admet-1570	144	15	plasma	plasma	NOUN
admet-1570	144	16	and	and	CCONJ
admet-1570	144	17	liver	liver	NOUN
admet-1570	144	18	interstitial	interstitial	ADJ
admet-1570	144	19	space	space	NOUN
admet-1570	144	20	is	be	AUX
admet-1570	144	21	flow	flow	NOUN
admet-1570	144	22	-	-	PUNCT
admet-1570	144	23	limited	limited	ADJ
admet-1570	144	24	[	[	X
admet-1570	144	25	20	20	NUM
admet-1570	144	26	]	]	PUNCT
admet-1570	144	27	,	,	PUNCT
admet-1570	144	28	that	that	ADV
admet-1570	144	29	is	is	ADV
admet-1570	144	30	,	,	PUNCT
admet-1570	144	31	the	the	DET
admet-1570	144	32	sinusoidal	sinusoidal	ADJ
admet-1570	144	33	exchange	exchange	NOUN
admet-1570	144	34	is	be	AUX
admet-1570	144	35	so	so	ADV
admet-1570	144	36	fast	fast	ADJ
admet-1570	144	37	it	it	PRON
admet-1570	144	38	is	be	AUX
admet-1570	144	39	as	as	SCONJ
admet-1570	144	40	if	if	SCONJ
admet-1570	144	41	the	the	DET
admet-1570	144	42	sinusoidal	sinusoidal	ADJ
admet-1570	144	43	barrier	barrier	NOUN
admet-1570	144	44	is	be	AUX
admet-1570	144	45	not	not	PART
admet-1570	144	46	present	present	ADJ
admet-1570	144	47	.	.	PUNCT
admet-1570	145	1	thus	thus	ADV
admet-1570	145	2	,	,	PUNCT
admet-1570	145	3	given	give	VERB
admet-1570	145	4	the	the	DET
admet-1570	145	5	high	high	ADJ
admet-1570	145	6	liver	liver	NOUN
admet-1570	145	7	blood	blood	NOUN
admet-1570	145	8	flow	flow	NOUN
admet-1570	145	9	,	,	PUNCT
admet-1570	145	10	the	the	DET
admet-1570	145	11	liver	liver	ADJ
admet-1570	145	12	interstitial	interstitial	ADJ
admet-1570	145	13	space	space	NOUN
admet-1570	145	14	should	should	AUX
admet-1570	145	15	equilibrate	equilibrate	VERB
admet-1570	145	16	with	with	ADP
admet-1570	145	17	the	the	DET
admet-1570	145	18	plasma	plasma	NOUN
admet-1570	145	19	within	within	ADP
admet-1570	145	20	a	a	DET
admet-1570	145	21	few	few	ADJ
admet-1570	145	22	minutes	minute	NOUN
admet-1570	145	23	.	.	PUNCT
admet-1570	146	1	in	in	ADP
admet-1570	146	2	the	the	DET
admet-1570	146	3	typical	typical	ADJ
admet-1570	146	4	pk	pk	PROPN
admet-1570	146	5	measurement	measurement	NOUN
admet-1570	146	6	,	,	PUNCT
admet-1570	146	7	one	one	NUM
admet-1570	146	8	waits	wait	VERB
admet-1570	146	9	for	for	ADP
admet-1570	146	10	about	about	ADV
admet-1570	146	11	5	5	NUM
admet-1570	146	12	to	to	PART
admet-1570	146	13	10	10	NUM
admet-1570	146	14	minutes	minute	NOUN
admet-1570	146	15	after	after	ADP
admet-1570	146	16	the	the	DET
admet-1570	146	17	bolus	bolus	ADJ
admet-1570	146	18	iv	iv	NUM
admet-1570	146	19	protein	protein	NOUN
admet-1570	146	20	injection	injection	NOUN
admet-1570	146	21	for	for	ADP
admet-1570	146	22	plasma	plasma	NOUN
admet-1570	146	23	equilibration	equilibration	NOUN
admet-1570	146	24	before	before	ADP
admet-1570	146	25	taking	take	VERB
admet-1570	146	26	the	the	DET
admet-1570	146	27	first	first	ADJ
admet-1570	146	28	plasma	plasma	NOUN
admet-1570	146	29	sample	sample	NOUN
admet-1570	146	30	to	to	PART
admet-1570	146	31	follow	follow	VERB
admet-1570	146	32	the	the	DET
admet-1570	146	33	rate	rate	NOUN
admet-1570	146	34	of	of	ADP
admet-1570	146	35	decrease	decrease	NOUN
admet-1570	146	36	in	in	ADP
admet-1570	146	37	concentration	concentration	NOUN
admet-1570	146	38	.	.	PUNCT
admet-1570	147	1	because	because	SCONJ
admet-1570	147	2	of	of	ADP
admet-1570	147	3	the	the	DET
admet-1570	147	4	flow	flow	NOUN
admet-1570	147	5	-	-	PUNCT
admet-1570	147	6	limited	limit	VERB
admet-1570	147	7	liver	liver	NOUN
admet-1570	147	8	protein	protein	NOUN
admet-1570	147	9	exchange	exchange	NOUN
admet-1570	147	10	,	,	PUNCT
admet-1570	147	11	the	the	DET
admet-1570	147	12	liver	liver	NOUN
admet-1570	147	13	will	will	AUX
admet-1570	147	14	have	have	AUX
admet-1570	147	15	completely	completely	ADV
admet-1570	147	16	equilibrated	equilibrate	VERB
admet-1570	147	17	before	before	SCONJ
admet-1570	147	18	the	the	DET
admet-1570	147	19	first	first	ADJ
admet-1570	147	20	sample	sample	NOUN
admet-1570	147	21	is	be	AUX
admet-1570	147	22	taken	take	VERB
admet-1570	147	23	,	,	PUNCT
admet-1570	147	24	and	and	CCONJ
admet-1570	147	25	it	it	PRON
admet-1570	147	26	will	will	AUX
admet-1570	147	27	not	not	PART
admet-1570	147	28	contribute	contribute	VERB
admet-1570	147	29	to	to	ADP
admet-1570	147	30	the	the	DET
admet-1570	147	31	subsequent	subsequent	ADJ
admet-1570	147	32	fall	fall	NOUN
admet-1570	147	33	in	in	ADP
admet-1570	147	34	plasma	plasma	NOUN
admet-1570	147	35	concentration	concentration	NOUN
admet-1570	147	36	.	.	PUNCT
admet-1570	148	1	thus	thus	ADV
admet-1570	148	2	,	,	PUNCT
admet-1570	148	3	in	in	ADP
admet-1570	148	4	our	our	PRON
admet-1570	148	5	model	model	NOUN
admet-1570	148	6	,	,	PUNCT
admet-1570	148	7	the	the	DET
admet-1570	148	8	liver	liver	NOUN
admet-1570	148	9	is	be	AUX
admet-1570	148	10	not	not	PART
admet-1570	148	11	included	include	VERB
admet-1570	148	12	in	in	ADP
admet-1570	148	13	the	the	DET
admet-1570	148	14	two	two	NUM
admet-1570	148	15	tissue	tissue	NOUN
admet-1570	148	16	compartments	compartment	NOUN
admet-1570	148	17	in	in	ADP
admet-1570	148	18	figure	figure	NOUN
admet-1570	148	19	1b	1b	NUM
admet-1570	148	20	and	and	CCONJ
admet-1570	148	21	the	the	DET
admet-1570	148	22	liver	liver	ADJ
admet-1570	148	23	interstitial	interstitial	ADJ
admet-1570	148	24	space	space	NOUN
admet-1570	148	25	is	be	AUX
admet-1570	148	26	regarded	regard	VERB
admet-1570	148	27	as	as	ADP
admet-1570	148	28	a	a	DET
admet-1570	148	29	component	component	NOUN
admet-1570	148	30	of	of	ADP
admet-1570	148	31	the	the	DET
admet-1570	148	32	plasma	plasma	NOUN
admet-1570	148	33	volume	volume	NOUN
admet-1570	148	34	vp	vp	PROPN
admet-1570	148	35	.	.	PUNCT
admet-1570	149	1	in	in	ADP
admet-1570	149	2	all	all	DET
admet-1570	149	3	the	the	DET
admet-1570	149	4	other	other	ADJ
admet-1570	149	5	non	non	ADJ
admet-1570	149	6	-	-	ADJ
admet-1570	149	7	liver	liver	ADJ
admet-1570	149	8	tissues	tissue	NOUN
admet-1570	149	9	,	,	PUNCT
admet-1570	149	10	albumin	albumin	NOUN
admet-1570	149	11	is	be	AUX
admet-1570	149	12	highly	highly	ADV
admet-1570	149	13	impermeable	impermeable	ADJ
admet-1570	149	14	,	,	PUNCT
admet-1570	149	15	as	as	SCONJ
admet-1570	149	16	indicated	indicate	VERB
admet-1570	149	17	by	by	ADP
admet-1570	149	18	the	the	DET
admet-1570	149	19	fact	fact	NOUN
admet-1570	149	20	that	that	SCONJ
admet-1570	149	21	it	it	PRON
admet-1570	149	22	exerts	exert	VERB
admet-1570	149	23	its	its	PRON
admet-1570	149	24	theoretical	theoretical	ADJ
admet-1570	149	25	colloid	colloid	NOUN
admet-1570	149	26	osmotic	osmotic	ADJ
admet-1570	149	27	pressure	pressure	NOUN
admet-1570	149	28	across	across	ADP
admet-1570	149	29	the	the	DET
admet-1570	149	30	capillary	capillary	ADJ
admet-1570	149	31	membrane	membrane	NOUN
admet-1570	149	32	,	,	PUNCT
admet-1570	149	33	which	which	PRON
admet-1570	149	34	is	be	AUX
admet-1570	149	35	essential	essential	ADJ
admet-1570	149	36	for	for	ADP
admet-1570	149	37	fluid	fluid	ADJ
admet-1570	149	38	balance	balance	NOUN
admet-1570	149	39	in	in	ADP
admet-1570	149	40	all	all	DET
admet-1570	149	41	these	these	DET
admet-1570	149	42	tissues	tissue	NOUN
admet-1570	149	43	.	.	PUNCT
admet-1570	150	1	although	although	SCONJ
admet-1570	150	2	the	the	DET
admet-1570	150	3	mechanism	mechanism	NOUN
admet-1570	150	4	of	of	ADP
admet-1570	150	5	the	the	DET
admet-1570	150	6	slow	slow	ADJ
admet-1570	150	7	convective	convective	ADJ
admet-1570	150	8	leak	leak	NOUN
admet-1570	150	9	is	be	AUX
admet-1570	150	10	poorly	poorly	ADV
admet-1570	150	11	understood	understand	VERB
admet-1570	150	12	,	,	PUNCT
admet-1570	150	13	whatever	whatever	PRON
admet-1570	150	14	the	the	DET
admet-1570	150	15	mechanism	mechanism	NOUN
admet-1570	150	16	,	,	PUNCT
admet-1570	150	17	we	we	PRON
admet-1570	150	18	think	think	VERB
admet-1570	150	19	it	it	PRON
admet-1570	150	20	is	be	AUX
admet-1570	150	21	likely	likely	ADJ
admet-1570	150	22	that	that	SCONJ
admet-1570	150	23	,	,	PUNCT
admet-1570	150	24	for	for	ADP
admet-1570	150	25	the	the	DET
admet-1570	150	26	same	same	ADJ
admet-1570	150	27	species	specie	NOUN
admet-1570	150	28	,	,	PUNCT
admet-1570	150	29	the	the	DET
admet-1570	150	30	value	value	NOUN
admet-1570	150	31	of	of	ADP
admet-1570	150	32	f	f	PROPN
admet-1570	150	33	should	should	AUX
admet-1570	150	34	be	be	AUX
admet-1570	150	35	roughly	roughly	ADV
admet-1570	150	36	the	the	DET
admet-1570	150	37	same	same	ADJ
admet-1570	150	38	in	in	ADP
admet-1570	150	39	all	all	DET
admet-1570	150	40	these	these	DET
admet-1570	150	41	non	non	ADJ
admet-1570	150	42	-	-	ADJ
admet-1570	150	43	liver	liver	ADJ
admet-1570	150	44	tissues	tissue	NOUN
admet-1570	150	45	.	.	PUNCT
admet-1570	151	1	it	it	PRON
admet-1570	151	2	should	should	AUX
admet-1570	151	3	be	be	AUX
admet-1570	151	4	noted	note	VERB
admet-1570	151	5	that	that	SCONJ
admet-1570	151	6	plasma	plasma	NOUN
admet-1570	151	7	protein	protein	NOUN
admet-1570	151	8	pk	pk	NOUN
admet-1570	151	9	is	be	AUX
admet-1570	151	10	quite	quite	ADV
admet-1570	151	11	simple	simple	ADJ
admet-1570	151	12	,	,	PUNCT
admet-1570	151	13	and	and	CCONJ
admet-1570	151	14	any	any	DET
admet-1570	151	15	model	model	NOUN
admet-1570	151	16	with	with	ADP
admet-1570	151	17	a	a	DET
admet-1570	151	18	few	few	ADJ
admet-1570	151	19	adjustable	adjustable	ADJ
admet-1570	151	20	parameters	parameter	NOUN
admet-1570	151	21	will	will	AUX
admet-1570	151	22	be	be	AUX
admet-1570	151	23	able	able	ADJ
admet-1570	151	24	to	to	PART
admet-1570	151	25	fit	fit	VERB
admet-1570	151	26	the	the	DET
admet-1570	151	27	plasma	plasma	NOUN
admet-1570	151	28	concentration	concentration	NOUN
admet-1570	151	29	data	datum	NOUN
admet-1570	151	30	.	.	PUNCT
admet-1570	152	1	the	the	DET
admet-1570	152	2	ability	ability	NOUN
admet-1570	152	3	of	of	ADP
admet-1570	152	4	the	the	DET
admet-1570	152	5	model	model	NOUN
admet-1570	152	6	to	to	PART
admet-1570	152	7	also	also	ADV
admet-1570	152	8	fit	fit	VERB
admet-1570	152	9	the	the	DET
admet-1570	152	10	experimental	experimental	ADJ
admet-1570	152	11	measurements	measurement	NOUN
admet-1570	152	12	of	of	ADP
admet-1570	152	13	the	the	DET
admet-1570	152	14	lymph	lymph	NOUN
admet-1570	152	15	concentration	concentration	NOUN
admet-1570	152	16	places	place	VERB
admet-1570	152	17	important	important	ADJ
admet-1570	152	18	additional	additional	ADJ
admet-1570	152	19	constraints	constraint	NOUN
admet-1570	152	20	on	on	ADP
admet-1570	152	21	the	the	DET
admet-1570	152	22	model	model	NOUN
admet-1570	152	23	and	and	CCONJ
admet-1570	152	24	is	be	AUX
admet-1570	152	25	a	a	DET
admet-1570	152	26	factor	factor	NOUN
admet-1570	152	27	that	that	PRON
admet-1570	152	28	we	we	PRON
admet-1570	152	29	have	have	AUX
admet-1570	152	30	emphasized	emphasize	VERB
admet-1570	152	31	in	in	ADP
admet-1570	152	32	this	this	DET
admet-1570	152	33	review	review	NOUN
admet-1570	152	34	.	.	PUNCT
admet-1570	153	1	the	the	DET
admet-1570	153	2	liver	liver	NOUN
admet-1570	153	3	does	do	AUX
admet-1570	153	4	complicate	complicate	VERB
admet-1570	153	5	the	the	DET
admet-1570	153	6	interpretation	interpretation	NOUN
admet-1570	153	7	of	of	ADP
admet-1570	153	8	the	the	DET
admet-1570	153	9	lymph	lymph	NOUN
admet-1570	153	10	measurements	measurement	NOUN
admet-1570	153	11	.	.	PUNCT
admet-1570	154	1	since	since	SCONJ
admet-1570	154	2	the	the	DET
admet-1570	154	3	liver	liver	NOUN
admet-1570	154	4	lymph	lymph	NOUN
admet-1570	154	5	flow	flow	NOUN
admet-1570	154	6	is	be	AUX
admet-1570	154	7	relatively	relatively	ADV
admet-1570	154	8	large	large	ADJ
admet-1570	154	9	,	,	PUNCT
admet-1570	154	10	about	about	ADV
admet-1570	154	11	20	20	NUM
admet-1570	154	12	%	%	NOUN
admet-1570	154	13	of	of	ADP
admet-1570	154	14	the	the	DET
admet-1570	154	15	thoracic	thoracic	NOUN
admet-1570	154	16	duct	duct	NOUN
admet-1570	154	17	flow	flow	NOUN
admet-1570	154	18	[	[	X
admet-1570	154	19	21	21	NUM
admet-1570	154	20	]	]	PUNCT
admet-1570	154	21	,	,	PUNCT
admet-1570	154	22	liver	liver	NOUN
admet-1570	154	23	lymphatics	lymphatic	NOUN
admet-1570	154	24	,	,	PUNCT
admet-1570	154	25	which	which	PRON
admet-1570	154	26	are	be	AUX
admet-1570	154	27	neglected	neglect	VERB
admet-1570	154	28	in	in	ADP
admet-1570	154	29	our	our	PRON
admet-1570	154	30	model	model	NOUN
admet-1570	154	31	,	,	PUNCT
admet-1570	154	32	should	should	AUX
admet-1570	154	33	make	make	VERB
admet-1570	154	34	a	a	DET
admet-1570	154	35	significant	significant	ADJ
admet-1570	154	36	contribution	contribution	NOUN
admet-1570	154	37	.	.	PUNCT
admet-1570	155	1	however	however	ADV
admet-1570	155	2	,	,	PUNCT
admet-1570	155	3	as	as	SCONJ
admet-1570	155	4	shown	show	VERB
admet-1570	155	5	below	below	ADV
admet-1570	155	6	,	,	PUNCT
admet-1570	155	7	lymph	lymph	NOUN
admet-1570	155	8	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	155	9	d.g	d.g	PROPN
admet-1570	155	10	.	.	PROPN
admet-1570	155	11	levitt	levitt	PROPN
admet-1570	155	12	and	and	CCONJ
admet-1570	155	13	m.d	m.d	PROPN
admet-1570	155	14	.	.	PROPN
admet-1570	155	15	levitt	levitt	PROPN
admet-1570	155	16	admet	admet	PROPN
admet-1570	155	17	&	&	CCONJ
admet-1570	155	18	dmpk	dmpk	PROPN
admet-1570	155	19	11(1	11(1	NUM
admet-1570	155	20	)	)	PUNCT
admet-1570	155	21	(	(	PUNCT
admet-1570	155	22	2023	2023	NUM
admet-1570	155	23	)	)	PUNCT
admet-1570	155	24	57	57	NUM
admet-1570	155	25	-	-	SYM
admet-1570	155	26	80	80	NUM
admet-1570	155	27	64	64	NUM
admet-1570	155	28	concentration	concentration	NOUN
admet-1570	155	29	measurements	measurement	NOUN
admet-1570	155	30	are	be	AUX
admet-1570	155	31	highly	highly	ADV
admet-1570	155	32	variable	variable	ADJ
admet-1570	155	33	and	and	CCONJ
admet-1570	155	34	deviations	deviation	NOUN
admet-1570	155	35	of	of	ADP
admet-1570	155	36	20	20	NUM
admet-1570	155	37	%	%	NOUN
admet-1570	155	38	are	be	AUX
admet-1570	155	39	not	not	PART
admet-1570	155	40	considered	consider	VERB
admet-1570	155	41	significant	significant	ADJ
admet-1570	155	42	.	.	PUNCT
admet-1570	156	1	the	the	DET
admet-1570	156	2	lumped	lump	VERB
admet-1570	156	3	tissue	tissue	NOUN
admet-1570	156	4	volumes	volume	NOUN
admet-1570	156	5	v1	v1	VERB
admet-1570	156	6	and	and	CCONJ
admet-1570	156	7	v2	v2	PROPN
admet-1570	156	8	and	and	CCONJ
admet-1570	156	9	the	the	DET
admet-1570	156	10	corresponding	corresponding	ADJ
admet-1570	156	11	lymph	lymph	NOUN
admet-1570	156	12	flows	flow	VERB
admet-1570	156	13	l1	l1	PROPN
admet-1570	156	14	and	and	CCONJ
admet-1570	156	15	l2	l2	NOUN
admet-1570	156	16	(	(	PUNCT
admet-1570	156	17	eq	eq	NOUN
admet-1570	156	18	.	.	NOUN
admet-1570	156	19	2	2	NUM
admet-1570	156	20	)	)	PUNCT
admet-1570	156	21	can	can	AUX
admet-1570	156	22	not	not	PART
admet-1570	156	23	be	be	AUX
admet-1570	156	24	directly	directly	ADV
admet-1570	156	25	measured	measure	VERB
admet-1570	156	26	experimentally	experimentally	ADV
admet-1570	156	27	.	.	PUNCT
admet-1570	157	1	they	they	PRON
admet-1570	157	2	are	be	AUX
admet-1570	157	3	simply	simply	ADV
admet-1570	157	4	model	model	NOUN
admet-1570	157	5	parameters	parameter	NOUN
admet-1570	157	6	that	that	PRON
admet-1570	157	7	are	be	AUX
admet-1570	157	8	empirically	empirically	ADV
admet-1570	157	9	adjusted	adjust	VERB
admet-1570	157	10	to	to	PART
admet-1570	157	11	fit	fit	VERB
admet-1570	157	12	,	,	PUNCT
admet-1570	157	13	at	at	ADP
admet-1570	157	14	least	least	ADJ
admet-1570	157	15	,	,	PUNCT
admet-1570	157	16	the	the	DET
admet-1570	157	17	following	follow	VERB
admet-1570	157	18	three	three	NUM
admet-1570	157	19	experimental	experimental	ADJ
admet-1570	157	20	observations	observation	NOUN
admet-1570	157	21	.	.	PUNCT
admet-1570	158	1	the	the	DET
admet-1570	158	2	total	total	ADJ
admet-1570	158	3	lymph	lymph	NOUN
admet-1570	158	4	flow	flow	NOUN
admet-1570	158	5	relation	relation	NOUN
admet-1570	158	6	:	:	PUNCT
admet-1570	158	7	1	1	NUM
admet-1570	158	8	2total	2total	NUM
admet-1570	158	9	lymph	lymph	NOUN
admet-1570	158	10	flow	flow	NOUN
admet-1570	158	11	=	=	SYM
admet-1570	158	12	l	l	NOUN
admet-1570	158	13	l	l	NOUN
admet-1570	158	14	(	(	PUNCT
admet-1570	158	15	4	4	X
admet-1570	158	16	)	)	PUNCT
admet-1570	158	17	the	the	DET
admet-1570	158	18	steady	steady	ADJ
admet-1570	158	19	-	-	PUNCT
admet-1570	158	20	state	state	NOUN
admet-1570	158	21	tissue	tissue	NOUN
admet-1570	158	22	concentrations	concentration	NOUN
admet-1570	158	23	are	be	AUX
admet-1570	158	24	described	describe	VERB
admet-1570	158	25	by	by	ADP
admet-1570	158	26	(	(	PUNCT
admet-1570	158	27	c1	c1	PROPN
admet-1570	158	28	/	/	SYM
admet-1570	158	29	cp)ss	cp)ss	PROPN
admet-1570	158	30	=	=	SYM
admet-1570	158	31	f1	f1	NOUN
admet-1570	158	32	and	and	CCONJ
admet-1570	158	33	(	(	PUNCT
admet-1570	158	34	c2	c2	PROPN
admet-1570	158	35	/	/	SYM
admet-1570	158	36	cp)ss	cp)ss	PROPN
admet-1570	158	37	=	=	SYM
admet-1570	158	38	f2	f2	PROPN
admet-1570	158	39	,	,	PUNCT
admet-1570	158	40	so	so	SCONJ
admet-1570	158	41	that	that	SCONJ
admet-1570	158	42	the	the	DET
admet-1570	158	43	experimentally	experimentally	ADV
admet-1570	158	44	measurable	measurable	ADJ
admet-1570	158	45	steady	steady	ADJ
admet-1570	158	46	-	-	PUNCT
admet-1570	158	47	state	state	NOUN
admet-1570	158	48	total	total	ADJ
admet-1570	158	49	lymph	lymph	NOUN
admet-1570	158	50	protein	protein	NOUN
admet-1570	158	51	concentration	concentration	NOUN
admet-1570	158	52	relative	relative	ADJ
admet-1570	158	53	to	to	ADP
admet-1570	158	54	the	the	DET
admet-1570	158	55	plasma	plasma	NOUN
admet-1570	158	56	concentration	concentration	NOUN
admet-1570	158	57	(	(	PUNCT
admet-1570	158	58	clss	clss	PROPN
admet-1570	158	59	/	/	SYM
admet-1570	158	60	cp	cp	NOUN
admet-1570	158	61	)	)	PUNCT
admet-1570	158	62	is	be	AUX
admet-1570	158	63	:	:	PUNCT
admet-1570	158	64	lss	lss	PROPN
admet-1570	158	65	1	1	NUM
admet-1570	158	66	1	1	NUM
admet-1570	158	67	2	2	NUM
admet-1570	158	68	2	2	NUM
admet-1570	158	69	ss	ss	NOUN
admet-1570	158	70	p	p	NOUN
admet-1570	158	71	1	1	NUM
admet-1570	158	72	2	2	NUM
admet-1570	158	73	c	c	NOUN
admet-1570	158	74	f	f	NOUN
admet-1570	158	75	l	l	NOUN
admet-1570	158	76	f	f	X
admet-1570	159	1	l	l	NOUN
admet-1570	159	2	c	c	NOUN
admet-1570	159	3	l	l	NOUN
admet-1570	159	4	l	l	NOUN
admet-1570	159	5	(	(	PUNCT
admet-1570	159	6	5	5	NUM
admet-1570	159	7	)	)	PUNCT
admet-1570	159	8	finally	finally	ADV
admet-1570	159	9	,	,	PUNCT
admet-1570	159	10	the	the	DET
admet-1570	159	11	steady	steady	ADJ
admet-1570	159	12	-	-	PUNCT
admet-1570	159	13	state	state	NOUN
admet-1570	159	14	extravascular	extravascular	ADJ
admet-1570	159	15	volume	volume	NOUN
admet-1570	159	16	of	of	ADP
admet-1570	159	17	distribution	distribution	NOUN
admet-1570	159	18	(	(	PUNCT
admet-1570	159	19	vecf	vecf	NOUN
admet-1570	159	20	)	)	PUNCT
admet-1570	159	21	,	,	PUNCT
admet-1570	159	22	which	which	PRON
admet-1570	159	23	can	can	AUX
admet-1570	159	24	be	be	AUX
admet-1570	159	25	determined	determine	VERB
admet-1570	159	26	experimentally	experimentally	ADV
admet-1570	159	27	from	from	ADP
admet-1570	159	28	the	the	DET
admet-1570	159	29	pk	pk	NOUN
admet-1570	159	30	following	follow	VERB
admet-1570	159	31	a	a	DET
admet-1570	159	32	bolus	bolus	ADJ
admet-1570	159	33	injection	injection	NOUN
admet-1570	160	1	[	[	X
admet-1570	160	2	18	18	NUM
admet-1570	160	3	]	]	PUNCT
admet-1570	160	4	,	,	PUNCT
admet-1570	160	5	is	be	AUX
admet-1570	160	6	described	describe	VERB
admet-1570	160	7	by	by	ADP
admet-1570	160	8	:	:	SYM
admet-1570	160	9	1	1	NUM
admet-1570	160	10	2	2	NUM
admet-1570	160	11	ecf	ecf	PROPN
admet-1570	160	12	1	1	NUM
admet-1570	160	13	1	1	NUM
admet-1570	160	14	2	2	NUM
admet-1570	160	15	2ss	2ss	NOUN
admet-1570	160	16	p	p	X
admet-1570	160	17	a	a	DET
admet-1570	160	18	a	a	DET
admet-1570	160	19	v	v	NOUN
admet-1570	160	20	f	f	NOUN
admet-1570	160	21	v	v	NOUN
admet-1570	160	22	f	f	PROPN
admet-1570	160	23	v	v	PROPN
admet-1570	160	24	c	c	PROPN
admet-1570	160	25	(	(	PUNCT
admet-1570	160	26	6	6	NUM
admet-1570	160	27	)	)	PUNCT
admet-1570	160	28	where	where	SCONJ
admet-1570	160	29	a1	a1	NOUN
admet-1570	160	30	and	and	CCONJ
admet-1570	160	31	a2	a2	PROPN
admet-1570	160	32	are	be	AUX
admet-1570	160	33	the	the	DET
admet-1570	160	34	steady	steady	ADJ
admet-1570	160	35	-	-	PUNCT
admet-1570	160	36	state	state	NOUN
admet-1570	160	37	amounts	amount	NOUN
admet-1570	160	38	in	in	ADP
admet-1570	160	39	the	the	DET
admet-1570	160	40	tissue	tissue	NOUN
admet-1570	160	41	compartments	compartment	NOUN
admet-1570	160	42	(	(	PUNCT
admet-1570	160	43	figure	figure	NOUN
admet-1570	160	44	1a	1a	NOUN
admet-1570	160	45	)	)	PUNCT
admet-1570	160	46	.	.	PUNCT
admet-1570	161	1	for	for	ADP
admet-1570	161	2	each	each	DET
admet-1570	161	3	experimental	experimental	ADJ
admet-1570	161	4	animal	animal	NOUN
admet-1570	161	5	model	model	NOUN
admet-1570	161	6	(	(	PUNCT
admet-1570	161	7	e.g.	e.g.	ADV
admet-1570	161	8	,	,	PUNCT
admet-1570	161	9	human	human	ADJ
admet-1570	161	10	,	,	PUNCT
admet-1570	161	11	dog	dog	NOUN
admet-1570	161	12	,	,	PUNCT
admet-1570	161	13	etc	etc	X
admet-1570	161	14	.	.	X
admet-1570	161	15	)	)	PUNCT
admet-1570	161	16	,	,	PUNCT
admet-1570	161	17	v1	v1	NOUN
admet-1570	161	18	and	and	CCONJ
admet-1570	161	19	v2	v2	PROPN
admet-1570	161	20	were	be	AUX
admet-1570	161	21	adjusted	adjust	VERB
admet-1570	161	22	to	to	PART
admet-1570	161	23	satisfy	satisfy	VERB
admet-1570	161	24	these	these	DET
admet-1570	161	25	three	three	NUM
admet-1570	161	26	experimental	experimental	ADJ
admet-1570	161	27	observations	observation	NOUN
admet-1570	161	28	(	(	PUNCT
admet-1570	161	29	eqs	eqs	X
admet-1570	161	30	.	.	PROPN
admet-1570	161	31	4	4	NUM
admet-1570	161	32	-	-	SYM
admet-1570	161	33	6	6	NUM
admet-1570	161	34	)	)	PUNCT
admet-1570	161	35	.	.	PUNCT
admet-1570	162	1	for	for	ADP
admet-1570	162	2	the	the	DET
admet-1570	162	3	human	human	NOUN
admet-1570	162	4	,	,	PUNCT
admet-1570	162	5	we	we	PRON
admet-1570	162	6	estimated	estimate	VERB
admet-1570	162	7	that	that	SCONJ
admet-1570	162	8	v1	v1	NOUN
admet-1570	162	9	/	/	SYM
admet-1570	162	10	vp	vp	NOUN
admet-1570	162	11	=	=	SYM
admet-1570	162	12	1.3	1.3	NUM
admet-1570	162	13	and	and	CCONJ
admet-1570	162	14	v2	v2	NOUN
admet-1570	162	15	/	/	SYM
admet-1570	162	16	vp	vp	NOUN
admet-1570	162	17	=	=	SYM
admet-1570	162	18	0.4	0.4	NUM
admet-1570	162	19	,	,	PUNCT
admet-1570	162	20	which	which	PRON
admet-1570	162	21	produces	produce	VERB
admet-1570	162	22	albumin	albumin	ADJ
admet-1570	162	23	sieving	sieve	VERB
admet-1570	162	24	factors	factor	NOUN
admet-1570	162	25	(	(	PUNCT
admet-1570	162	26	eq.2	eq.2	NOUN
admet-1570	162	27	)	)	PUNCT
admet-1570	162	28	f1	f1	NOUN
admet-1570	162	29	=	=	NOUN
admet-1570	162	30	0.73	0.73	NUM
admet-1570	162	31	and	and	CCONJ
admet-1570	162	32	f2=0.725	f2=0.725	NOUN
admet-1570	162	33	.	.	PUNCT
admet-1570	163	1	these	these	DET
admet-1570	163	2	values	value	NOUN
admet-1570	163	3	satisfy	satisfy	VERB
admet-1570	163	4	the	the	DET
admet-1570	163	5	3	3	NUM
admet-1570	163	6	conditions	condition	NOUN
admet-1570	163	7	(	(	PUNCT
admet-1570	163	8	eqs	eqs	X
admet-1570	163	9	.	.	PROPN
admet-1570	163	10	46	46	NUM
admet-1570	163	11	)	)	PUNCT
admet-1570	163	12	for	for	ADP
admet-1570	163	13	albumin	albumin	NOUN
admet-1570	163	14	.	.	PUNCT
admet-1570	164	1	the	the	DET
admet-1570	164	2	corresponding	corresponding	ADJ
admet-1570	164	3	lymph	lymph	NOUN
admet-1570	164	4	flows	flow	VERB
admet-1570	164	5	(	(	PUNCT
admet-1570	164	6	eq	eq	NOUN
admet-1570	164	7	.	.	NOUN
admet-1570	164	8	2	2	NUM
admet-1570	164	9	)	)	PUNCT
admet-1570	164	10	are	be	AUX
admet-1570	164	11	l1	l1	PROPN
admet-1570	164	12	=	=	PROPN
admet-1570	164	13	0.87	0.87	NUM
admet-1570	164	14	ml	ml	NOUN
admet-1570	164	15	/	/	SYM
admet-1570	164	16	min	min	PROPN
admet-1570	164	17	and	and	CCONJ
admet-1570	164	18	l2=2	l2=2	PROPN
admet-1570	164	19	ml	ml	PROPN
admet-1570	164	20	/	/	SYM
admet-1570	164	21	min	min	NOUN
admet-1570	164	22	for	for	ADP
admet-1570	164	23	a	a	DET
admet-1570	164	24	total	total	ADJ
admet-1570	164	25	lymph	lymph	NOUN
admet-1570	164	26	flow	flow	NOUN
admet-1570	164	27	(	(	PUNCT
admet-1570	164	28	eq	eq	NOUN
admet-1570	164	29	.	.	NOUN
admet-1570	164	30	4	4	NUM
admet-1570	164	31	)	)	PUNCT
admet-1570	164	32	of	of	ADP
admet-1570	164	33	2.8	2.8	NUM
admet-1570	164	34	ml	ml	NOUN
admet-1570	164	35	/	/	SYM
admet-1570	164	36	min	min	NOUN
admet-1570	164	37	.	.	PROPN
admet-1570	164	38	although	although	SCONJ
admet-1570	164	39	there	there	PRON
admet-1570	164	40	is	be	VERB
admet-1570	164	41	no	no	DET
admet-1570	164	42	measurement	measurement	NOUN
admet-1570	164	43	of	of	ADP
admet-1570	164	44	normal	normal	ADJ
admet-1570	164	45	human	human	ADJ
admet-1570	164	46	total	total	NOUN
admet-1570	164	47	lymph	lymph	NOUN
admet-1570	164	48	flow	flow	NOUN
admet-1570	164	49	(	(	PUNCT
admet-1570	164	50	thoracic	thoracic	NOUN
admet-1570	164	51	duct	duct	NOUN
admet-1570	164	52	plus	plus	CCONJ
admet-1570	164	53	right	right	ADJ
admet-1570	164	54	lymph	lymph	NOUN
admet-1570	164	55	duct	duct	NOUN
admet-1570	164	56	)	)	PUNCT
admet-1570	164	57	,	,	PUNCT
admet-1570	164	58	this	this	DET
admet-1570	164	59	result	result	NOUN
admet-1570	164	60	is	be	AUX
admet-1570	164	61	similar	similar	ADJ
admet-1570	164	62	to	to	ADP
admet-1570	164	63	the	the	DET
admet-1570	164	64	few	few	ADJ
admet-1570	164	65	available	available	ADJ
admet-1570	164	66	normal	normal	ADJ
admet-1570	164	67	human	human	ADJ
admet-1570	164	68	thoracic	thoracic	NOUN
admet-1570	164	69	duct	duct	NOUN
admet-1570	164	70	measurements	measurement	NOUN
admet-1570	164	71	[	[	X
admet-1570	164	72	22,23	22,23	NOUN
admet-1570	164	73	]	]	X
admet-1570	164	74	.	.	PUNCT
admet-1570	165	1	the	the	DET
admet-1570	165	2	corresponding	corresponding	ADJ
admet-1570	165	3	theoretical	theoretical	ADJ
admet-1570	165	4	steady	steady	ADJ
admet-1570	165	5	state	state	NOUN
admet-1570	165	6	albumin	albumin	ADJ
admet-1570	165	7	lymph	lymph	NOUN
admet-1570	165	8	/	/	SYM
admet-1570	165	9	plasma	plasma	NOUN
admet-1570	165	10	ratio	ratio	NOUN
admet-1570	165	11	(	(	PUNCT
admet-1570	165	12	eq	eq	NOUN
admet-1570	165	13	.	.	NOUN
admet-1570	165	14	5	5	NUM
admet-1570	165	15	)	)	PUNCT
admet-1570	165	16	is	be	AUX
admet-1570	165	17	0.725	0.725	NUM
admet-1570	165	18	,	,	PUNCT
admet-1570	165	19	identical	identical	ADJ
admet-1570	165	20	to	to	ADP
admet-1570	165	21	that	that	PRON
admet-1570	165	22	reported	report	VERB
admet-1570	165	23	by	by	ADP
admet-1570	165	24	witte	witte	PROPN
admet-1570	165	25	et	et	PROPN
admet-1570	165	26	al	al	PROPN
admet-1570	165	27	.	.	PUNCT
admet-1570	166	1	[	[	X
admet-1570	166	2	24	24	NUM
admet-1570	166	3	]	]	PUNCT
admet-1570	166	4	for	for	ADP
admet-1570	166	5	human	human	ADJ
admet-1570	166	6	thoracic	thoracic	NOUN
admet-1570	166	7	duct	duct	NOUN
admet-1570	166	8	lymph	lymph	NOUN
admet-1570	166	9	.	.	PUNCT
admet-1570	167	1	finally	finally	ADV
admet-1570	167	2	,	,	PUNCT
admet-1570	167	3	vecf	vecf	PROPN
admet-1570	167	4	(	(	PUNCT
admet-1570	167	5	eq	eq	NOUN
admet-1570	167	6	.	.	NOUN
admet-1570	167	7	6	6	NUM
admet-1570	167	8	)	)	PUNCT
admet-1570	167	9	is	be	AUX
admet-1570	167	10	3479	3479	NUM
admet-1570	167	11	ml	ml	NOUN
admet-1570	167	12	,	,	PUNCT
admet-1570	167	13	similar	similar	ADJ
admet-1570	167	14	to	to	ADP
admet-1570	167	15	the	the	DET
admet-1570	167	16	value	value	NOUN
admet-1570	167	17	of	of	ADP
admet-1570	167	18	3250	3250	NUM
admet-1570	167	19	determined	determine	VERB
admet-1570	167	20	from	from	ADP
admet-1570	167	21	the	the	DET
admet-1570	167	22	pk	pk	NOUN
admet-1570	167	23	analysis	analysis	NOUN
admet-1570	167	24	following	follow	VERB
admet-1570	167	25	the	the	DET
admet-1570	167	26	bolus	bolus	ADJ
admet-1570	167	27	iv	iv	NUM
admet-1570	167	28	injection	injection	NOUN
admet-1570	167	29	(	(	PUNCT
admet-1570	167	30	figure	figure	NOUN
admet-1570	167	31	2	2	NUM
admet-1570	167	32	)	)	PUNCT
admet-1570	167	33	.	.	PUNCT
admet-1570	168	1	these	these	DET
admet-1570	168	2	physiological	physiological	ADJ
admet-1570	168	3	parameters	parameter	NOUN
admet-1570	168	4	for	for	ADP
admet-1570	168	5	albumin	albumin	NOUN
admet-1570	168	6	and	and	CCONJ
admet-1570	168	7	all	all	DET
admet-1570	168	8	the	the	DET
admet-1570	168	9	other	other	ADJ
admet-1570	168	10	proteins	protein	NOUN
admet-1570	168	11	studied	study	VERB
admet-1570	168	12	are	be	AUX
admet-1570	168	13	summarized	summarize	VERB
admet-1570	168	14	in	in	ADP
admet-1570	168	15	table	table	NOUN
admet-1570	168	16	2	2	NUM
admet-1570	168	17	.	.	PUNCT
admet-1570	168	18	tissue	tissue	NOUN
admet-1570	168	19	region	region	NOUN
admet-1570	168	20	1	1	NUM
admet-1570	168	21	,	,	PUNCT
admet-1570	168	22	which	which	PRON
admet-1570	168	23	has	have	VERB
admet-1570	168	24	a	a	DET
admet-1570	168	25	larger	large	ADJ
admet-1570	168	26	volume	volume	NOUN
admet-1570	168	27	(	(	PUNCT
admet-1570	168	28	v1	v1	NOUN
admet-1570	168	29	/	/	SYM
admet-1570	168	30	vp	vp	NOUN
admet-1570	168	31	=	=	SYM
admet-1570	168	32	1.3	1.3	NUM
admet-1570	168	33	)	)	PUNCT
admet-1570	168	34	and	and	CCONJ
admet-1570	168	35	slower	slow	ADJ
admet-1570	168	36	turnover	turnover	NOUN
admet-1570	168	37	time	time	NOUN
admet-1570	168	38	(	(	PUNCT
admet-1570	168	39	t1=	t1=	NOUN
admet-1570	168	40	4182	4182	NUM
admet-1570	168	41	minutes	minute	NOUN
admet-1570	168	42	)	)	PUNCT
admet-1570	168	43	,	,	PUNCT
admet-1570	168	44	presumably	presumably	ADV
admet-1570	168	45	corresponds	correspond	VERB
admet-1570	168	46	to	to	ADP
admet-1570	168	47	the	the	DET
admet-1570	168	48	lumped	lump	VERB
admet-1570	168	49	tissues	tissue	NOUN
admet-1570	168	50	with	with	ADP
admet-1570	168	51	relatively	relatively	ADV
admet-1570	168	52	low	low	ADJ
admet-1570	168	53	lymph	lymph	NOUN
admet-1570	168	54	flows	flow	NOUN
admet-1570	168	55	such	such	ADJ
admet-1570	168	56	as	as	ADP
admet-1570	168	57	the	the	DET
admet-1570	168	58	skin	skin	NOUN
admet-1570	168	59	,	,	PUNCT
admet-1570	168	60	subcutaneous	subcutaneous	ADJ
admet-1570	168	61	and	and	CCONJ
admet-1570	168	62	skeletal	skeletal	ADJ
admet-1570	168	63	muscle	muscle	NOUN
admet-1570	168	64	tissues	tissue	NOUN
admet-1570	168	65	,	,	PUNCT
admet-1570	168	66	while	while	SCONJ
admet-1570	168	67	tissue	tissue	NOUN
admet-1570	168	68	region	region	NOUN
admet-1570	168	69	2	2	NUM
admet-1570	168	70	,	,	PUNCT
admet-1570	168	71	with	with	ADP
admet-1570	168	72	the	the	DET
admet-1570	168	73	smaller	small	ADJ
admet-1570	168	74	volume	volume	NOUN
admet-1570	168	75	(	(	PUNCT
admet-1570	168	76	v2	v2	NOUN
admet-1570	168	77	/	/	SYM
admet-1570	168	78	vp	vp	NOUN
admet-1570	168	79	=	=	NOUN
admet-1570	168	80	0.4	0.4	NUM
admet-1570	168	81	)	)	PUNCT
admet-1570	168	82	and	and	CCONJ
admet-1570	168	83	faster	fast	ADJ
admet-1570	168	84	turnover	turnover	NOUN
admet-1570	168	85	time	time	NOUN
admet-1570	168	86	(	(	PUNCT
admet-1570	168	87	t2=557	t2=557	NOUN
admet-1570	168	88	minutes	minute	NOUN
admet-1570	168	89	)	)	PUNCT
admet-1570	168	90	,	,	PUNCT
admet-1570	168	91	presumably	presumably	ADV
admet-1570	168	92	corresponds	correspond	VERB
admet-1570	168	93	to	to	ADP
admet-1570	168	94	the	the	DET
admet-1570	168	95	gi	gi	PROPN
admet-1570	168	96	tract	tract	NOUN
admet-1570	168	97	which	which	PRON
admet-1570	168	98	is	be	AUX
admet-1570	168	99	known	know	VERB
admet-1570	168	100	to	to	PART
admet-1570	168	101	have	have	VERB
admet-1570	168	102	a	a	DET
admet-1570	168	103	relatively	relatively	ADV
admet-1570	168	104	high	high	ADJ
admet-1570	168	105	lymph	lymph	NOUN
admet-1570	168	106	flow	flow	NOUN
admet-1570	168	107	rate	rate	NOUN
admet-1570	169	1	[	[	X
admet-1570	169	2	13	13	NUM
admet-1570	169	3	]	]	PUNCT
admet-1570	169	4	.	.	PUNCT
admet-1570	170	1	the	the	DET
admet-1570	170	2	physiological	physiological	ADJ
admet-1570	170	3	model	model	NOUN
admet-1570	170	4	fit	fit	ADJ
admet-1570	170	5	to	to	ADP
admet-1570	170	6	the	the	DET
admet-1570	170	7	albumin	albumin	ADJ
admet-1570	170	8	data	datum	NOUN
admet-1570	170	9	is	be	AUX
admet-1570	170	10	identical	identical	ADJ
admet-1570	170	11	to	to	ADP
admet-1570	170	12	the	the	DET
admet-1570	170	13	compartment	compartment	NOUN
admet-1570	170	14	fit	fit	NOUN
admet-1570	170	15	(	(	PUNCT
admet-1570	170	16	figure	figure	NOUN
admet-1570	170	17	2	2	NUM
admet-1570	170	18	)	)	PUNCT
admet-1570	170	19	because	because	SCONJ
admet-1570	170	20	we	we	PRON
admet-1570	170	21	have	have	AUX
admet-1570	170	22	defined	define	VERB
admet-1570	170	23	the	the	DET
admet-1570	170	24	albumin	albumin	ADJ
admet-1570	170	25	physiological	physiological	ADJ
admet-1570	170	26	parameters	parameter	NOUN
admet-1570	170	27	(	(	PUNCT
admet-1570	170	28	table	table	NOUN
admet-1570	170	29	2	2	NUM
admet-1570	170	30	)	)	PUNCT
admet-1570	170	31	directly	directly	ADV
admet-1570	170	32	in	in	ADP
admet-1570	170	33	terms	term	NOUN
admet-1570	170	34	of	of	ADP
admet-1570	170	35	the	the	DET
admet-1570	170	36	previously	previously	ADV
admet-1570	170	37	determined	determine	VERB
admet-1570	170	38	compartmental	compartmental	ADJ
admet-1570	170	39	parameters	parameter	NOUN
admet-1570	170	40	(	(	PUNCT
admet-1570	170	41	table	table	NOUN
admet-1570	170	42	1	1	NUM
admet-1570	170	43	,	,	PUNCT
admet-1570	170	44	eq	eq	NOUN
admet-1570	170	45	.	.	PROPN
admet-1570	170	46	2	2	NUM
admet-1570	170	47	)	)	PUNCT
admet-1570	170	48	.	.	PUNCT
admet-1570	171	1	the	the	DET
admet-1570	171	2	focus	focus	NOUN
admet-1570	171	3	of	of	ADP
admet-1570	171	4	this	this	DET
admet-1570	171	5	review	review	NOUN
admet-1570	171	6	is	be	AUX
admet-1570	171	7	on	on	ADP
admet-1570	171	8	the	the	DET
admet-1570	171	9	pk	pk	NOUN
admet-1570	171	10	,	,	PUNCT
admet-1570	171	11	not	not	PART
admet-1570	171	12	on	on	ADP
admet-1570	171	13	the	the	DET
admet-1570	171	14	detailed	detail	VERB
admet-1570	171	15	metabolic	metabolic	NOUN
admet-1570	171	16	mechanisms	mechanism	NOUN
admet-1570	171	17	.	.	PUNCT
admet-1570	172	1	the	the	DET
admet-1570	172	2	main	main	ADJ
admet-1570	172	3	assumption	assumption	NOUN
admet-1570	172	4	of	of	ADP
admet-1570	172	5	both	both	CCONJ
admet-1570	172	6	the	the	DET
admet-1570	172	7	compartmental	compartmental	ADJ
admet-1570	172	8	and	and	CCONJ
admet-1570	172	9	physiological	physiological	ADJ
admet-1570	172	10	model	model	NOUN
admet-1570	172	11	is	be	AUX
admet-1570	172	12	that	that	SCONJ
admet-1570	172	13	the	the	DET
admet-1570	172	14	catabolism	catabolism	NOUN
admet-1570	172	15	or	or	CCONJ
admet-1570	172	16	clearance	clearance	NOUN
admet-1570	172	17	occurs	occur	VERB
admet-1570	172	18	from	from	ADP
admet-1570	172	19	the	the	DET
admet-1570	172	20	plasma	plasma	NOUN
admet-1570	172	21	space	space	NOUN
admet-1570	172	22	,	,	PUNCT
admet-1570	172	23	i.e.	i.e.	X
admet-1570	172	24	,	,	PUNCT
admet-1570	172	25	it	it	PRON
admet-1570	172	26	is	be	AUX
admet-1570	172	27	proportional	proportional	ADJ
admet-1570	172	28	to	to	ADP
admet-1570	172	29	the	the	DET
admet-1570	172	30	plasma	plasma	NOUN
admet-1570	172	31	concentration	concentration	NOUN
admet-1570	172	32	.	.	PUNCT
admet-1570	173	1	both	both	CCONJ
admet-1570	173	2	albumin	albumin	NOUN
admet-1570	173	3	and	and	CCONJ
admet-1570	173	4	immunoglobulins	immunoglobulin	NOUN
admet-1570	173	5	are	be	AUX
admet-1570	173	6	known	know	VERB
admet-1570	173	7	to	to	PART
admet-1570	173	8	be	be	AUX
admet-1570	173	9	metabolized	metabolize	VERB
admet-1570	173	10	by	by	ADP
admet-1570	173	11	endosomal	endosomal	ADJ
admet-1570	173	12	metabolism	metabolism	NOUN
admet-1570	173	13	that	that	PRON
admet-1570	173	14	is	be	AUX
admet-1570	173	15	moderated	moderate	VERB
admet-1570	173	16	by	by	ADP
admet-1570	173	17	fcrn	fcrn	NOUN
admet-1570	173	18	binding	bind	VERB
admet-1570	173	19	[	[	X
admet-1570	173	20	5,7,25	5,7,25	NUM
admet-1570	173	21	]	]	PUNCT
admet-1570	173	22	.	.	PUNCT
admet-1570	174	1	since	since	SCONJ
admet-1570	174	2	this	this	DET
admet-1570	174	3	endosomal	endosomal	ADJ
admet-1570	174	4	space	space	NOUN
admet-1570	174	5	is	be	AUX
admet-1570	174	6	usually	usually	ADV
admet-1570	174	7	assumed	assume	VERB
admet-1570	174	8	to	to	PART
admet-1570	174	9	be	be	AUX
admet-1570	174	10	located	locate	VERB
admet-1570	174	11	in	in	ADP
admet-1570	174	12	the	the	DET
admet-1570	174	13	vascular	vascular	ADJ
admet-1570	174	14	endothelium	endothelium	NOUN
admet-1570	174	15	[	[	X
admet-1570	174	16	5,7	5,7	NUM
admet-1570	174	17	]	]	PUNCT
admet-1570	174	18	which	which	PRON
admet-1570	174	19	is	be	AUX
admet-1570	174	20	in	in	ADP
admet-1570	174	21	contact	contact	NOUN
admet-1570	174	22	with	with	ADP
admet-1570	174	23	the	the	DET
admet-1570	174	24	blood	blood	NOUN
admet-1570	174	25	,	,	PUNCT
admet-1570	174	26	this	this	PRON
admet-1570	174	27	is	be	AUX
admet-1570	174	28	consistent	consistent	ADJ
admet-1570	174	29	with	with	ADP
admet-1570	174	30	the	the	DET
admet-1570	174	31	metabolic	metabolic	NOUN
admet-1570	174	32	assumption	assumption	NOUN
admet-1570	174	33	.	.	PUNCT
admet-1570	175	1	similarly	similarly	ADV
admet-1570	175	2	,	,	PUNCT
admet-1570	175	3	the	the	DET
admet-1570	175	4	diagnostic	diagnostic	ADJ
admet-1570	175	5	enzymes	enzyme	NOUN
admet-1570	175	6	are	be	AUX
admet-1570	175	7	either	either	ADV
admet-1570	175	8	metabolized	metabolize	VERB
admet-1570	175	9	by	by	ADP
admet-1570	175	10	the	the	DET
admet-1570	175	11	liver	liver	NOUN
admet-1570	175	12	or	or	CCONJ
admet-1570	175	13	cleared	clear	VERB
admet-1570	175	14	by	by	ADP
admet-1570	175	15	the	the	DET
admet-1570	175	16	kidney	kidney	NOUN
admet-1570	175	17	(	(	PUNCT
admet-1570	175	18	table	table	NOUN
admet-1570	175	19	1	1	NUM
admet-1570	175	20	)	)	PUNCT
admet-1570	175	21	,	,	PUNCT
admet-1570	175	22	both	both	PRON
admet-1570	175	23	of	of	ADP
admet-1570	175	24	which	which	PRON
admet-1570	175	25	are	be	AUX
admet-1570	175	26	also	also	ADV
admet-1570	175	27	proportional	proportional	ADJ
admet-1570	175	28	to	to	ADP
admet-1570	175	29	the	the	DET
admet-1570	175	30	plasma	plasma	NOUN
admet-1570	175	31	concentration	concentration	NOUN
admet-1570	175	32	.	.	PUNCT
admet-1570	176	1	admet	admet	PROPN
admet-1570	176	2	&	&	CCONJ
admet-1570	176	3	dmpk	dmpk	PROPN
admet-1570	176	4	11(1	11(1	NUM
admet-1570	176	5	)	)	PUNCT
admet-1570	176	6	(	(	PUNCT
admet-1570	176	7	2023	2023	NUM
admet-1570	176	8	)	)	PUNCT
admet-1570	176	9	57	57	NUM
admet-1570	176	10	-	-	SYM
admet-1570	176	11	80	80	NUM
admet-1570	176	12	protein	protein	NOUN
admet-1570	176	13	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	176	14	model	model	NOUN
admet-1570	176	15	doi	doi	PROPN
admet-1570	176	16	:	:	PUNCT
admet-1570	176	17	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	176	18	65	65	NUM
admet-1570	176	19	monoclonal	monoclonal	NOUN
admet-1570	176	20	antibodies	antibodie	VERB
admet-1570	176	21	.	.	PUNCT
admet-1570	177	1	igg	igg	PROPN
admet-1570	177	2	and	and	CCONJ
admet-1570	177	3	albumin	albumin	PROPN
admet-1570	177	4	are	be	AUX
admet-1570	177	5	the	the	DET
admet-1570	177	6	classical	classical	ADJ
admet-1570	177	7	markers	marker	NOUN
admet-1570	177	8	of	of	ADP
admet-1570	177	9	capillary	capillary	ADJ
admet-1570	177	10	protein	protein	NOUN
admet-1570	177	11	permeability	permeability	NOUN
admet-1570	177	12	.	.	PUNCT
admet-1570	178	1	with	with	ADP
admet-1570	178	2	a	a	DET
admet-1570	178	3	molecular	molecular	ADJ
admet-1570	178	4	weight	weight	NOUN
admet-1570	178	5	about	about	ADV
admet-1570	178	6	twice	twice	DET
admet-1570	178	7	that	that	PRON
admet-1570	178	8	of	of	ADP
admet-1570	178	9	albumin	albumin	NOUN
admet-1570	178	10	,	,	PUNCT
admet-1570	178	11	igg	igg	PROPN
admet-1570	178	12	has	have	VERB
admet-1570	178	13	a	a	DET
admet-1570	178	14	lower	low	ADJ
admet-1570	178	15	filtration	filtration	NOUN
admet-1570	178	16	coefficient	coefficient	NOUN
admet-1570	178	17	and	and	CCONJ
admet-1570	178	18	a	a	DET
admet-1570	178	19	corresponding	correspond	VERB
admet-1570	178	20	lower	low	ADJ
admet-1570	178	21	steady	steady	ADJ
admet-1570	178	22	-	-	PUNCT
admet-1570	178	23	state	state	NOUN
admet-1570	178	24	lymph	lymph	NOUN
admet-1570	178	25	concentration	concentration	NOUN
admet-1570	178	26	,	,	PUNCT
admet-1570	178	27	about	about	ADV
admet-1570	178	28	60	60	NUM
admet-1570	178	29	%	%	NOUN
admet-1570	178	30	that	that	DET
admet-1570	178	31	of	of	ADP
admet-1570	178	32	albumin	albumin	NOUN
admet-1570	178	33	[	[	X
admet-1570	178	34	24,26,27	24,26,27	NUM
admet-1570	178	35	]	]	PUNCT
admet-1570	178	36	.	.	PUNCT
admet-1570	179	1	the	the	DET
admet-1570	179	2	recent	recent	ADJ
admet-1570	179	3	development	development	NOUN
admet-1570	179	4	of	of	ADP
admet-1570	179	5	monoclonal	monoclonal	NOUN
admet-1570	179	6	antibodies	antibody	NOUN
admet-1570	179	7	for	for	ADP
admet-1570	179	8	therapeutic	therapeutic	ADJ
admet-1570	179	9	purposes	purpose	NOUN
admet-1570	179	10	has	have	AUX
admet-1570	179	11	resulted	result	VERB
admet-1570	179	12	in	in	ADP
admet-1570	179	13	an	an	DET
admet-1570	179	14	extensive	extensive	ADJ
admet-1570	179	15	investigation	investigation	NOUN
admet-1570	179	16	of	of	ADP
admet-1570	179	17	the	the	DET
admet-1570	179	18	human	human	ADJ
admet-1570	179	19	pk	pk	NOUN
admet-1570	179	20	of	of	ADP
admet-1570	179	21	these	these	DET
admet-1570	179	22	proteins	protein	NOUN
admet-1570	179	23	and	and	CCONJ
admet-1570	179	24	has	have	AUX
admet-1570	179	25	been	be	AUX
admet-1570	179	26	the	the	DET
admet-1570	179	27	subject	subject	NOUN
admet-1570	179	28	of	of	ADP
admet-1570	179	29	several	several	ADJ
admet-1570	179	30	recent	recent	ADJ
admet-1570	179	31	reviews	review	NOUN
admet-1570	179	32	[	[	X
admet-1570	179	33	28	28	NUM
admet-1570	179	34	-	-	SYM
admet-1570	179	35	30	30	NUM
admet-1570	179	36	]	]	PUNCT
admet-1570	179	37	.	.	PUNCT
admet-1570	180	1	figure	figure	NOUN
admet-1570	180	2	3	3	NUM
admet-1570	180	3	(	(	PUNCT
admet-1570	180	4	left	leave	VERB
admet-1570	180	5	panel	panel	NOUN
admet-1570	180	6	)	)	PUNCT
admet-1570	180	7	shows	show	VERB
admet-1570	180	8	the	the	DET
admet-1570	180	9	physiological	physiological	ADJ
admet-1570	180	10	model	model	NOUN
admet-1570	180	11	fit	fit	ADJ
admet-1570	180	12	to	to	ADP
admet-1570	180	13	the	the	DET
admet-1570	180	14	data	datum	NOUN
admet-1570	180	15	of	of	ADP
admet-1570	180	16	smith	smith	PROPN
admet-1570	180	17	et	et	PROPN
admet-1570	180	18	al	al	PROPN
admet-1570	180	19	.	.	PUNCT
admet-1570	181	1	[	[	X
admet-1570	181	2	31	31	NUM
admet-1570	181	3	]	]	PUNCT
admet-1570	181	4	for	for	ADP
admet-1570	181	5	the	the	DET
admet-1570	181	6	plasma	plasma	NOUN
admet-1570	181	7	disappearance	disappearance	NOUN
admet-1570	181	8	curve	curve	NOUN
admet-1570	181	9	of	of	ADP
admet-1570	181	10	an	an	DET
admet-1570	181	11	iv	iv	NUM
admet-1570	181	12	bolus	bolus	ADJ
admet-1570	181	13	infusion	infusion	NOUN
admet-1570	181	14	of	of	ADP
admet-1570	181	15	the	the	DET
admet-1570	181	16	monoclonal	monoclonal	NOUN
admet-1570	181	17	antibody	antibody	NOUN
admet-1570	181	18	mepolizumab	mepolizumab	NOUN
admet-1570	181	19	.	.	PUNCT
admet-1570	182	1	as	as	SCONJ
admet-1570	182	2	discussed	discuss	VERB
admet-1570	182	3	,	,	PUNCT
admet-1570	182	4	since	since	SCONJ
admet-1570	182	5	the	the	DET
admet-1570	182	6	lymph	lymph	NOUN
admet-1570	182	7	flows	flow	VERB
admet-1570	182	8	(	(	PUNCT
admet-1570	182	9	l1	l1	PROPN
admet-1570	182	10	,	,	PUNCT
admet-1570	182	11	l2	l2	NOUN
admet-1570	182	12	)	)	PUNCT
admet-1570	182	13	and	and	CCONJ
admet-1570	182	14	tissue	tissue	NOUN
admet-1570	182	15	volumes	volume	NOUN
admet-1570	182	16	should	should	AUX
admet-1570	182	17	be	be	AUX
admet-1570	182	18	equal	equal	ADJ
admet-1570	182	19	to	to	ADP
admet-1570	182	20	those	those	PRON
admet-1570	182	21	determined	determine	VERB
admet-1570	182	22	above	above	ADV
admet-1570	182	23	for	for	ADP
admet-1570	182	24	albumin	albumin	NOUN
admet-1570	182	25	in	in	ADP
admet-1570	182	26	the	the	DET
admet-1570	182	27	human	human	NOUN
admet-1570	182	28	,	,	PUNCT
admet-1570	182	29	there	there	PRON
admet-1570	182	30	are	be	VERB
admet-1570	182	31	only	only	ADV
admet-1570	182	32	two	two	NUM
admet-1570	182	33	parameters	parameter	NOUN
admet-1570	182	34	that	that	PRON
admet-1570	182	35	can	can	AUX
admet-1570	182	36	be	be	AUX
admet-1570	182	37	adjusted	adjust	VERB
admet-1570	182	38	to	to	PART
admet-1570	182	39	fit	fit	VERB
admet-1570	182	40	this	this	DET
admet-1570	182	41	data	datum	NOUN
admet-1570	182	42	,	,	PUNCT
admet-1570	182	43	the	the	DET
admet-1570	182	44	plasma	plasma	NOUN
admet-1570	182	45	clearance	clearance	NOUN
admet-1570	182	46	(	(	PUNCT
admet-1570	182	47	clp	clp	PROPN
admet-1570	182	48	)	)	PUNCT
admet-1570	182	49	and	and	CCONJ
admet-1570	182	50	the	the	DET
admet-1570	182	51	filtration	filtration	NOUN
admet-1570	182	52	constant	constant	ADJ
admet-1570	182	53	f	f	X
admet-1570	182	54	(	(	PUNCT
admet-1570	182	55	≈	≈	PROPN
admet-1570	182	56	f1	f1	PROPN
admet-1570	182	57	≈	≈	PROPN
admet-1570	182	58	f2	f2	PROPN
admet-1570	182	59	)	)	PUNCT
admet-1570	182	60	,	,	PUNCT
admet-1570	182	61	which	which	PRON
admet-1570	182	62	should	should	AUX
admet-1570	182	63	be	be	AUX
admet-1570	182	64	less	less	ADJ
admet-1570	182	65	than	than	ADP
admet-1570	182	66	then	then	ADV
admet-1570	182	67	the	the	DET
admet-1570	182	68	albumin	albumin	ADJ
admet-1570	182	69	value	value	NOUN
admet-1570	182	70	of	of	ADP
admet-1570	182	71	f=0.73	f=0.73	NOUN
admet-1570	182	72	since	since	SCONJ
admet-1570	182	73	mepolizumab	mepolizumab	NOUN
admet-1570	182	74	has	have	VERB
admet-1570	182	75	a	a	DET
admet-1570	182	76	molecular	molecular	ADJ
admet-1570	182	77	weight	weight	NOUN
admet-1570	182	78	2.2	2.2	NUM
admet-1570	182	79	times	time	NOUN
admet-1570	182	80	that	that	PRON
admet-1570	182	81	of	of	ADP
admet-1570	182	82	albumin	albumin	NOUN
admet-1570	182	83	.	.	PUNCT
admet-1570	183	1	the	the	DET
admet-1570	183	2	physiological	physiological	ADJ
admet-1570	183	3	model	model	NOUN
admet-1570	183	4	fit	fit	ADJ
admet-1570	183	5	in	in	ADP
admet-1570	183	6	figure	figure	NOUN
admet-1570	183	7	3	3	NUM
admet-1570	183	8	is	be	AUX
admet-1570	183	9	in	in	ADP
admet-1570	183	10	accord	accord	NOUN
admet-1570	183	11	with	with	ADP
admet-1570	183	12	these	these	DET
admet-1570	183	13	restrictions	restriction	NOUN
admet-1570	183	14	,	,	PUNCT
admet-1570	183	15	having	have	VERB
admet-1570	183	16	an	an	DET
admet-1570	183	17	f1	f1	NOUN
admet-1570	183	18	=	=	PROPN
admet-1570	183	19	0.367	0.367	NUM
admet-1570	183	20	and	and	CCONJ
admet-1570	183	21	f2	f2	PRON
admet-1570	183	22	=	=	NUM
admet-1570	183	23	0.361	0.361	NUM
admet-1570	183	24	,	,	PUNCT
admet-1570	183	25	half	half	DET
admet-1570	183	26	that	that	PRON
admet-1570	183	27	for	for	ADP
admet-1570	183	28	albumin	albumin	NOUN
admet-1570	183	29	,	,	PUNCT
admet-1570	183	30	and	and	CCONJ
admet-1570	183	31	the	the	DET
admet-1570	183	32	same	same	ADJ
admet-1570	183	33	lymph	lymph	NOUN
admet-1570	183	34	flows	flow	NOUN
admet-1570	183	35	and	and	CCONJ
admet-1570	183	36	tissue	tissue	NOUN
admet-1570	183	37	volumes	volume	NOUN
admet-1570	183	38	used	use	VERB
admet-1570	183	39	for	for	ADP
admet-1570	183	40	albumin	albumin	NOUN
admet-1570	183	41	(	(	PUNCT
admet-1570	183	42	summarized	summarize	VERB
admet-1570	183	43	in	in	ADP
admet-1570	183	44	table	table	NOUN
admet-1570	183	45	2	2	NUM
admet-1570	183	46	)	)	PUNCT
admet-1570	183	47	.	.	PUNCT
admet-1570	184	1	as	as	SCONJ
admet-1570	184	2	predicted	predict	VERB
admet-1570	184	3	by	by	ADP
admet-1570	184	4	the	the	DET
admet-1570	184	5	physiological	physiological	ADJ
admet-1570	184	6	model	model	NOUN
admet-1570	184	7	,	,	PUNCT
admet-1570	184	8	the	the	DET
admet-1570	184	9	pk	pk	NOUN
admet-1570	184	10	of	of	ADP
admet-1570	184	11	another	another	DET
admet-1570	184	12	monoclonal	monoclonal	NOUN
admet-1570	184	13	,	,	PUNCT
admet-1570	184	14	infliximab	infliximab	NOUN
admet-1570	185	1	[	[	X
admet-1570	185	2	32	32	NUM
admet-1570	185	3	]	]	PUNCT
admet-1570	185	4	,	,	PUNCT
admet-1570	185	5	was	be	AUX
admet-1570	185	6	accurately	accurately	ADV
admet-1570	185	7	described	describe	VERB
admet-1570	185	8	by	by	ADP
admet-1570	185	9	adjusting	adjust	VERB
admet-1570	185	10	only	only	ADV
admet-1570	185	11	clp	clp	NOUN
admet-1570	185	12	,	,	PUNCT
admet-1570	185	13	with	with	ADP
admet-1570	185	14	all	all	DET
admet-1570	185	15	the	the	DET
admet-1570	185	16	other	other	ADJ
admet-1570	185	17	parameters	parameter	NOUN
admet-1570	185	18	identical	identical	ADJ
admet-1570	185	19	to	to	ADP
admet-1570	185	20	those	those	PRON
admet-1570	185	21	for	for	ADP
admet-1570	185	22	mepolizumab	mepolizumab	NOUN
admet-1570	185	23	since	since	SCONJ
admet-1570	185	24	it	it	PRON
admet-1570	185	25	has	have	VERB
admet-1570	185	26	a	a	DET
admet-1570	185	27	nearly	nearly	ADV
admet-1570	185	28	identical	identical	ADJ
admet-1570	185	29	structure	structure	NOUN
admet-1570	185	30	and	and	CCONJ
admet-1570	185	31	,	,	PUNCT
admet-1570	185	32	therefore	therefore	ADV
admet-1570	185	33	,	,	PUNCT
admet-1570	185	34	should	should	AUX
admet-1570	185	35	have	have	VERB
admet-1570	185	36	identical	identical	ADJ
admet-1570	185	37	filtration	filtration	NOUN
admet-1570	185	38	constants	constant	NOUN
admet-1570	185	39	(	(	PUNCT
admet-1570	185	40	data	datum	NOUN
admet-1570	185	41	in	in	ADP
admet-1570	185	42	table	table	NOUN
admet-1570	185	43	2	2	NUM
admet-1570	185	44	,	,	PUNCT
admet-1570	185	45	figure	figure	NOUN
admet-1570	185	46	3	3	NUM
admet-1570	185	47	,	,	PUNCT
admet-1570	185	48	right	right	ADJ
admet-1570	185	49	panel	panel	NOUN
admet-1570	185	50	)	)	PUNCT
admet-1570	185	51	.	.	PUNCT
admet-1570	186	1	figure	figure	VERB
admet-1570	186	2	3	3	NUM
admet-1570	186	3	.	.	NOUN
admet-1570	186	4	comparison	comparison	NOUN
admet-1570	186	5	of	of	ADP
admet-1570	186	6	pk	pk	NOUN
admet-1570	186	7	physiological	physiological	ADJ
admet-1570	186	8	protein	protein	NOUN
admet-1570	186	9	model	model	NOUN
admet-1570	186	10	prediction	prediction	NOUN
admet-1570	186	11	(	(	PUNCT
admet-1570	186	12	line	line	NOUN
admet-1570	186	13	)	)	PUNCT
admet-1570	186	14	following	follow	VERB
admet-1570	186	15	iv	iv	NUM
admet-1570	186	16	bolus	bolus	ADJ
admet-1570	186	17	monoclonal	monoclonal	NOUN
admet-1570	186	18	antibody	antibody	NOUN
admet-1570	186	19	injection	injection	NOUN
admet-1570	186	20	in	in	ADP
admet-1570	186	21	the	the	DET
admet-1570	186	22	human	human	NOUN
admet-1570	186	23	versus	versus	ADP
admet-1570	186	24	experimental	experimental	ADJ
admet-1570	186	25	data	datum	NOUN
admet-1570	186	26	(	(	PUNCT
admet-1570	186	27	solid	solid	ADJ
admet-1570	186	28	circles	circle	NOUN
admet-1570	186	29	)	)	PUNCT
admet-1570	186	30	.	.	PUNCT
admet-1570	187	1	left	leave	VERB
admet-1570	187	2	panel	panel	NOUN
admet-1570	187	3	:	:	PUNCT
admet-1570	187	4	mepolizumab	mepolizumab	NOUN
admet-1570	187	5	;	;	PUNCT
admet-1570	187	6	right	right	ADJ
admet-1570	187	7	panel	panel	NOUN
admet-1570	187	8	:	:	PUNCT
admet-1570	187	9	infliximab	infliximab	NOUN
admet-1570	187	10	.	.	PUNCT
admet-1570	188	1	only	only	ADV
admet-1570	188	2	one	one	NUM
admet-1570	188	3	parameter	parameter	NOUN
admet-1570	188	4	(	(	PUNCT
admet-1570	188	5	plasma	plasma	NOUN
admet-1570	188	6	clearance	clearance	NOUN
admet-1570	188	7	)	)	PUNCT
admet-1570	188	8	differs	differ	VERB
admet-1570	188	9	for	for	ADP
admet-1570	188	10	the	the	DET
admet-1570	188	11	two	two	NUM
admet-1570	188	12	model	model	NOUN
admet-1570	188	13	fits	fit	VERB
admet-1570	188	14	.	.	PUNCT
admet-1570	189	1	in	in	ADP
admet-1570	189	2	addition	addition	NOUN
admet-1570	189	3	to	to	ADP
admet-1570	189	4	the	the	DET
admet-1570	189	5	iv	iv	ADJ
admet-1570	189	6	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	189	7	for	for	ADP
admet-1570	189	8	mepolizumab	mepolizumab	NOUN
admet-1570	189	9	,	,	PUNCT
admet-1570	189	10	smith	smith	PROPN
admet-1570	189	11	et	et	PROPN
admet-1570	189	12	al	al	PROPN
admet-1570	189	13	.	.	PUNCT
admet-1570	190	1	[	[	X
admet-1570	190	2	31	31	NUM
admet-1570	190	3	]	]	PUNCT
admet-1570	190	4	also	also	ADV
admet-1570	190	5	described	describe	VERB
admet-1570	190	6	the	the	DET
admet-1570	190	7	plasma	plasma	NOUN
admet-1570	190	8	concentration	concentration	NOUN
admet-1570	190	9	following	follow	VERB
admet-1570	190	10	a	a	DET
admet-1570	190	11	bolus	bolus	ADJ
admet-1570	190	12	subcutaneous	subcutaneous	ADJ
admet-1570	190	13	injection	injection	NOUN
admet-1570	190	14	.	.	PUNCT
admet-1570	191	1	it	it	PRON
admet-1570	191	2	is	be	AUX
admet-1570	191	3	of	of	ADP
admet-1570	191	4	interest	interest	NOUN
admet-1570	191	5	to	to	PART
admet-1570	191	6	determine	determine	VERB
admet-1570	191	7	if	if	SCONJ
admet-1570	191	8	this	this	DET
admet-1570	191	9	data	data	NOUN
admet-1570	191	10	is	be	AUX
admet-1570	191	11	consistent	consistent	ADJ
admet-1570	191	12	with	with	ADP
admet-1570	191	13	the	the	DET
admet-1570	191	14	predictions	prediction	NOUN
admet-1570	191	15	of	of	ADP
admet-1570	191	16	the	the	DET
admet-1570	191	17	physiological	physiological	ADJ
admet-1570	191	18	model	model	NOUN
admet-1570	191	19	(	(	PUNCT
admet-1570	191	20	figure	figure	NOUN
admet-1570	191	21	1b	1b	NUM
admet-1570	191	22	)	)	PUNCT
admet-1570	191	23	using	use	VERB
admet-1570	191	24	parameters	parameter	NOUN
admet-1570	191	25	identical	identical	ADJ
admet-1570	191	26	to	to	ADP
admet-1570	191	27	those	those	PRON
admet-1570	191	28	determined	determine	VERB
admet-1570	191	29	from	from	ADP
admet-1570	191	30	the	the	DET
admet-1570	191	31	iv	iv	NUM
admet-1570	191	32	input	input	NOUN
admet-1570	191	33	data	datum	NOUN
admet-1570	191	34	(	(	PUNCT
admet-1570	191	35	figure	figure	NOUN
admet-1570	191	36	3	3	NUM
admet-1570	191	37	,	,	PUNCT
admet-1570	191	38	table	table	NOUN
admet-1570	191	39	2	2	NUM
admet-1570	191	40	)	)	PUNCT
admet-1570	191	41	.	.	PUNCT
admet-1570	192	1	as	as	SCONJ
admet-1570	192	2	discussed	discuss	VERB
admet-1570	192	3	above	above	ADV
admet-1570	192	4	,	,	PUNCT
admet-1570	192	5	the	the	DET
admet-1570	192	6	slower	slow	ADJ
admet-1570	192	7	lymph	lymph	NOUN
admet-1570	192	8	flow	flow	NOUN
admet-1570	192	9	,	,	PUNCT
admet-1570	192	10	longer	long	ADV
admet-1570	192	11	turnover	turnover	NOUN
admet-1570	192	12	time	time	NOUN
admet-1570	192	13	region	region	NOUN
admet-1570	192	14	v1	v1	PROPN
admet-1570	192	15	presumably	presumably	ADV
admet-1570	192	16	corresponds	correspond	VERB
admet-1570	192	17	roughly	roughly	ADV
admet-1570	192	18	to	to	ADP
admet-1570	192	19	that	that	PRON
admet-1570	192	20	of	of	ADP
admet-1570	192	21	the	the	DET
admet-1570	192	22	subcutaneous	subcutaneous	ADJ
admet-1570	192	23	tissue	tissue	NOUN
admet-1570	192	24	.	.	PUNCT
admet-1570	193	1	thus	thus	ADV
admet-1570	193	2	,	,	PUNCT
admet-1570	193	3	the	the	DET
admet-1570	193	4	subcutaneous	subcutaneous	ADJ
admet-1570	193	5	dose	dose	NOUN
admet-1570	193	6	of	of	ADP
admet-1570	193	7	mepolizumab	mepolizumab	NOUN
admet-1570	193	8	was	be	AUX
admet-1570	193	9	presumably	presumably	ADV
admet-1570	193	10	injected	inject	VERB
admet-1570	193	11	into	into	ADP
admet-1570	193	12	a	a	DET
admet-1570	193	13	tissue	tissue	NOUN
admet-1570	193	14	with	with	ADP
admet-1570	193	15	kinetics	kinetic	NOUN
admet-1570	193	16	similar	similar	ADJ
admet-1570	193	17	to	to	ADP
admet-1570	193	18	that	that	PRON
admet-1570	193	19	of	of	ADP
admet-1570	193	20	v1	v1	PROPN
admet-1570	193	21	.	.	PUNCT
admet-1570	194	1	figure	figure	NOUN
admet-1570	194	2	4	4	NUM
admet-1570	194	3	compares	compare	VERB
admet-1570	194	4	the	the	DET
admet-1570	194	5	experimental	experimental	ADJ
admet-1570	194	6	plasma	plasma	NOUN
admet-1570	194	7	concentration	concentration	NOUN
admet-1570	194	8	following	follow	VERB
admet-1570	194	9	the	the	DET
admet-1570	194	10	subcutaneous	subcutaneous	ADJ
admet-1570	194	11	injection	injection	NOUN
admet-1570	194	12	versus	versus	ADP
admet-1570	194	13	the	the	DET
admet-1570	194	14	physiological	physiological	ADJ
admet-1570	194	15	model	model	NOUN
admet-1570	194	16	prediction	prediction	NOUN
admet-1570	194	17	for	for	ADP
admet-1570	194	18	a	a	DET
admet-1570	194	19	bolus	bolus	NOUN
admet-1570	194	20	dose	dose	NOUN
admet-1570	194	21	into	into	ADP
admet-1570	194	22	tissue	tissue	NOUN
admet-1570	194	23	v1	v1	NOUN
admet-1570	194	24	using	use	VERB
admet-1570	194	25	the	the	DET
admet-1570	194	26	identical	identical	ADJ
admet-1570	194	27	model	model	NOUN
admet-1570	194	28	parameters	parameter	NOUN
admet-1570	194	29	obtained	obtain	VERB
admet-1570	194	30	from	from	ADP
admet-1570	194	31	the	the	DET
admet-1570	194	32	iv	iv	NUM
admet-1570	194	33	input	input	NOUN
admet-1570	194	34	(	(	PUNCT
admet-1570	194	35	figure	figure	NOUN
admet-1570	194	36	3	3	NUM
admet-1570	194	37	)	)	PUNCT
admet-1570	194	38	,	,	PUNCT
admet-1570	194	39	with	with	ADP
admet-1570	194	40	no	no	DET
admet-1570	194	41	adjustable	adjustable	ADJ
admet-1570	194	42	parameters	parameter	NOUN
admet-1570	194	43	.	.	PUNCT
admet-1570	195	1	the	the	DET
admet-1570	195	2	agreement	agreement	NOUN
admet-1570	195	3	between	between	ADP
admet-1570	195	4	model	model	NOUN
admet-1570	195	5	prediction	prediction	NOUN
admet-1570	195	6	and	and	CCONJ
admet-1570	195	7	experimental	experimental	ADJ
admet-1570	195	8	data	datum	NOUN
admet-1570	195	9	is	be	AUX
admet-1570	195	10	remarkably	remarkably	ADV
admet-1570	195	11	good	good	ADJ
admet-1570	195	12	,	,	PUNCT
admet-1570	195	13	given	give	VERB
admet-1570	195	14	the	the	DET
admet-1570	195	15	simple	simple	ADJ
admet-1570	195	16	two	two	NUM
admet-1570	195	17	-	-	PUNCT
admet-1570	195	18	tissue	tissue	NOUN
admet-1570	195	19	compartment	compartment	NOUN
admet-1570	195	20	model	model	NOUN
admet-1570	195	21	assumption	assumption	NOUN
admet-1570	195	22	.	.	PUNCT
admet-1570	196	1	this	this	DET
admet-1570	196	2	result	result	NOUN
admet-1570	196	3	provides	provide	VERB
admet-1570	196	4	additional	additional	ADJ
admet-1570	196	5	support	support	NOUN
admet-1570	196	6	for	for	ADP
admet-1570	196	7	the	the	DET
admet-1570	196	8	physiological	physiological	ADJ
admet-1570	196	9	model	model	NOUN
admet-1570	196	10	(	(	PUNCT
admet-1570	196	11	figure	figure	NOUN
admet-1570	196	12	1b	1b	NUM
admet-1570	196	13	)	)	PUNCT
admet-1570	196	14	with	with	ADP
admet-1570	196	15	its	its	PRON
admet-1570	196	16	corresponding	corresponding	ADJ
admet-1570	196	17	quantitative	quantitative	ADJ
admet-1570	196	18	implications	implication	NOUN
admet-1570	196	19	for	for	ADP
admet-1570	196	20	the	the	DET
admet-1570	196	21	lymph	lymph	NOUN
admet-1570	196	22	flow	flow	NOUN
admet-1570	196	23	rates	rate	NOUN
admet-1570	196	24	(	(	PUNCT
admet-1570	196	25	eq	eq	NOUN
admet-1570	196	26	.	.	NOUN
admet-1570	196	27	2	2	NUM
admet-1570	196	28	)	)	PUNCT
admet-1570	196	29	.	.	PUNCT
admet-1570	197	1	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	198	1	d.g	d.g	PROPN
admet-1570	198	2	.	.	PROPN
admet-1570	198	3	levitt	levitt	PROPN
admet-1570	198	4	and	and	CCONJ
admet-1570	198	5	m.d	m.d	PROPN
admet-1570	198	6	.	.	PROPN
admet-1570	198	7	levitt	levitt	PROPN
admet-1570	198	8	admet	admet	PROPN
admet-1570	198	9	&	&	CCONJ
admet-1570	198	10	dmpk	dmpk	PROPN
admet-1570	198	11	11(1	11(1	NUM
admet-1570	198	12	)	)	PUNCT
admet-1570	198	13	(	(	PUNCT
admet-1570	198	14	2023	2023	NUM
admet-1570	198	15	)	)	PUNCT
admet-1570	198	16	57	57	NUM
admet-1570	198	17	-	-	SYM
admet-1570	198	18	80	80	NUM
admet-1570	198	19	66	66	NUM
admet-1570	198	20	figure	figure	NOUN
admet-1570	198	21	4	4	NUM
admet-1570	198	22	.	.	NOUN
admet-1570	198	23	comparison	comparison	NOUN
admet-1570	198	24	of	of	ADP
admet-1570	198	25	physiological	physiological	ADJ
admet-1570	198	26	protein	protein	NOUN
admet-1570	198	27	model	model	NOUN
admet-1570	198	28	prediction	prediction	NOUN
admet-1570	198	29	(	(	PUNCT
admet-1570	198	30	line	line	NOUN
admet-1570	198	31	)	)	PUNCT
admet-1570	198	32	of	of	ADP
admet-1570	198	33	the	the	DET
admet-1570	198	34	plasma	plasma	NOUN
admet-1570	198	35	concentration	concentration	NOUN
admet-1570	198	36	following	follow	VERB
admet-1570	198	37	a	a	DET
admet-1570	198	38	subcutaneous	subcutaneous	ADJ
admet-1570	198	39	bolus	bolus	ADJ
admet-1570	198	40	mepolizumab	mepolizumab	NOUN
admet-1570	198	41	injection	injection	NOUN
admet-1570	198	42	in	in	ADP
admet-1570	198	43	the	the	DET
admet-1570	198	44	human	human	NOUN
admet-1570	198	45	versus	versus	ADP
admet-1570	198	46	experimental	experimental	ADJ
admet-1570	198	47	data	datum	NOUN
admet-1570	198	48	(	(	PUNCT
admet-1570	198	49	solid	solid	ADJ
admet-1570	198	50	circles	circle	NOUN
admet-1570	198	51	)	)	PUNCT
admet-1570	198	52	using	use	VERB
admet-1570	198	53	the	the	DET
admet-1570	198	54	identical	identical	ADJ
admet-1570	198	55	model	model	NOUN
admet-1570	198	56	parameters	parameter	NOUN
admet-1570	198	57	used	use	VERB
admet-1570	198	58	for	for	ADP
admet-1570	198	59	iv	iv	NUM
admet-1570	198	60	input	input	NOUN
admet-1570	198	61	in	in	ADP
admet-1570	198	62	figure	figure	NOUN
admet-1570	198	63	3	3	NUM
admet-1570	198	64	.	.	NOUN
admet-1570	198	65	amylase	amylase	NOUN
admet-1570	198	66	and	and	CCONJ
admet-1570	198	67	lipase	lipase	NOUN
admet-1570	198	68	lipase	lipase	NOUN
admet-1570	198	69	and	and	CCONJ
admet-1570	198	70	amylase	amylase	NOUN
admet-1570	198	71	,	,	PUNCT
admet-1570	198	72	two	two	NUM
admet-1570	198	73	enzymes	enzyme	NOUN
admet-1570	198	74	used	use	VERB
admet-1570	198	75	to	to	PART
admet-1570	198	76	assess	assess	VERB
admet-1570	198	77	the	the	DET
admet-1570	198	78	pancreatic	pancreatic	ADJ
admet-1570	198	79	injury	injury	NOUN
admet-1570	198	80	,	,	PUNCT
admet-1570	198	81	are	be	AUX
admet-1570	198	82	unique	unique	ADJ
admet-1570	198	83	among	among	ADP
admet-1570	198	84	the	the	DET
admet-1570	198	85	proteins	protein	NOUN
admet-1570	198	86	listed	list	VERB
admet-1570	198	87	in	in	ADP
admet-1570	198	88	table	table	NOUN
admet-1570	198	89	1	1	NUM
admet-1570	198	90	in	in	SCONJ
admet-1570	198	91	that	that	SCONJ
admet-1570	198	92	they	they	PRON
admet-1570	198	93	are	be	AUX
admet-1570	198	94	cleared	clear	VERB
admet-1570	198	95	primarily	primarily	ADV
admet-1570	198	96	by	by	ADP
admet-1570	198	97	the	the	DET
admet-1570	198	98	kidney	kidney	NOUN
admet-1570	198	99	.	.	PUNCT
admet-1570	199	1	junge	junge	PROPN
admet-1570	199	2	and	and	CCONJ
admet-1570	199	3	colleagues	colleague	NOUN
admet-1570	200	1	[	[	X
admet-1570	200	2	33,34	33,34	NOUN
admet-1570	200	3	]	]	PUNCT
admet-1570	200	4	have	have	AUX
admet-1570	200	5	elucidated	elucidate	VERB
admet-1570	200	6	their	their	PRON
admet-1570	200	7	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	200	8	in	in	ADP
admet-1570	200	9	the	the	DET
admet-1570	200	10	rat	rat	NOUN
admet-1570	200	11	.	.	PUNCT
admet-1570	201	1	both	both	PRON
admet-1570	201	2	are	be	AUX
admet-1570	201	3	rapidly	rapidly	ADV
admet-1570	201	4	cleared	clear	VERB
admet-1570	201	5	from	from	ADP
admet-1570	201	6	the	the	DET
admet-1570	201	7	blood	blood	NOUN
admet-1570	201	8	with	with	ADP
admet-1570	201	9	a	a	DET
admet-1570	201	10	single	single	ADJ
admet-1570	201	11	compartment	compartment	NOUN
admet-1570	201	12	,	,	PUNCT
admet-1570	201	13	oneexponential	oneexponential	ADJ
admet-1570	201	14	metabolic	metabolic	NOUN
admet-1570	201	15	time	time	NOUN
admet-1570	201	16	constants	constant	VERB
admet-1570	201	17	tm	tm	PROPN
admet-1570	201	18	of	of	ADP
admet-1570	201	19	31	31	NUM
admet-1570	201	20	min	min	NOUN
admet-1570	201	21	and	and	CCONJ
admet-1570	201	22	26	26	NUM
admet-1570	201	23	min	min	NOUN
admet-1570	201	24	for	for	ADP
admet-1570	201	25	amylase	amylase	NOUN
admet-1570	201	26	and	and	CCONJ
admet-1570	201	27	lipase	lipase	NOUN
admet-1570	201	28	,	,	PUNCT
admet-1570	201	29	respectively	respectively	ADV
admet-1570	201	30	.	.	PUNCT
admet-1570	202	1	about	about	ADV
admet-1570	202	2	70	70	NUM
admet-1570	202	3	%	%	NOUN
admet-1570	202	4	of	of	ADP
admet-1570	202	5	this	this	DET
admet-1570	202	6	clearance	clearance	NOUN
admet-1570	202	7	is	be	AUX
admet-1570	202	8	renal	renal	ADJ
admet-1570	202	9	,	,	PUNCT
admet-1570	202	10	with	with	ADP
admet-1570	202	11	both	both	DET
admet-1570	202	12	enzymes	enzyme	NOUN
admet-1570	202	13	having	have	VERB
admet-1570	202	14	surprisingly	surprisingly	ADV
admet-1570	202	15	high	high	ADJ
admet-1570	202	16	glomerular	glomerular	ADJ
admet-1570	202	17	filtration	filtration	NOUN
admet-1570	202	18	rates	rate	NOUN
admet-1570	202	19	,	,	PUNCT
admet-1570	202	20	roughly	roughly	ADV
admet-1570	202	21	12	12	NUM
admet-1570	202	22	%	%	NOUN
admet-1570	202	23	of	of	ADP
admet-1570	202	24	inulin	inulin	NOUN
admet-1570	202	25	.	.	PUNCT
admet-1570	203	1	about	about	ADV
admet-1570	203	2	84	84	NUM
admet-1570	203	3	%	%	NOUN
admet-1570	203	4	of	of	ADP
admet-1570	203	5	the	the	DET
admet-1570	203	6	filtered	filter	VERB
admet-1570	203	7	amylase	amylase	NOUN
admet-1570	203	8	appears	appear	VERB
admet-1570	203	9	in	in	ADP
admet-1570	203	10	the	the	DET
admet-1570	203	11	urine	urine	NOUN
admet-1570	203	12	as	as	ADP
admet-1570	203	13	an	an	DET
admet-1570	203	14	intact	intact	ADJ
admet-1570	203	15	,	,	PUNCT
admet-1570	203	16	enzymatically	enzymatically	ADV
admet-1570	203	17	active	active	ADJ
admet-1570	203	18	protein	protein	NOUN
admet-1570	203	19	,	,	PUNCT
admet-1570	203	20	while	while	SCONJ
admet-1570	203	21	nearly	nearly	ADV
admet-1570	203	22	all	all	DET
admet-1570	203	23	the	the	DET
admet-1570	203	24	filtered	filter	VERB
admet-1570	203	25	lipase	lipase	NOUN
admet-1570	203	26	is	be	AUX
admet-1570	203	27	metabolized	metabolize	VERB
admet-1570	203	28	by	by	ADP
admet-1570	203	29	the	the	DET
admet-1570	203	30	kidney	kidney	NOUN
admet-1570	203	31	with	with	ADP
admet-1570	203	32	negligible	negligible	ADJ
admet-1570	203	33	amounts	amount	NOUN
admet-1570	203	34	of	of	ADP
admet-1570	203	35	active	active	ADJ
admet-1570	203	36	enzyme	enzyme	NOUN
admet-1570	203	37	appearing	appear	VERB
admet-1570	203	38	in	in	ADP
admet-1570	203	39	the	the	DET
admet-1570	203	40	urine	urine	NOUN
admet-1570	203	41	.	.	PUNCT
admet-1570	204	1	figure	figure	NOUN
admet-1570	204	2	5	5	NUM
admet-1570	204	3	.	.	PUNCT
admet-1570	204	4	comparison	comparison	NOUN
admet-1570	204	5	of	of	ADP
admet-1570	204	6	pk	pk	NOUN
admet-1570	204	7	physiological	physiological	ADJ
admet-1570	204	8	protein	protein	NOUN
admet-1570	204	9	model	model	NOUN
admet-1570	204	10	prediction	prediction	NOUN
admet-1570	204	11	(	(	PUNCT
admet-1570	204	12	line	line	NOUN
admet-1570	204	13	)	)	PUNCT
admet-1570	204	14	following	follow	VERB
admet-1570	204	15	iv	iv	NUM
admet-1570	204	16	bolus	bolus	NOUN
admet-1570	204	17	of	of	ADP
admet-1570	204	18	baboon	baboon	NOUN
admet-1570	204	19	purified	purify	VERB
admet-1570	204	20	pancreatic	pancreatic	ADJ
admet-1570	204	21	amylase	amylase	NOUN
admet-1570	204	22	versus	versus	ADP
admet-1570	204	23	the	the	DET
admet-1570	204	24	experimental	experimental	ADJ
admet-1570	204	25	data	datum	NOUN
admet-1570	204	26	in	in	ADP
admet-1570	204	27	baboon	baboon	PROPN
admet-1570	204	28	(	(	PUNCT
admet-1570	204	29	solid	solid	ADJ
admet-1570	204	30	circles	circle	NOUN
admet-1570	204	31	)	)	PUNCT
admet-1570	204	32	.	.	PUNCT
admet-1570	205	1	the	the	DET
admet-1570	205	2	activity	activity	NOUN
admet-1570	205	3	is	be	AUX
admet-1570	205	4	plotted	plot	VERB
admet-1570	205	5	with	with	ADP
admet-1570	205	6	the	the	DET
admet-1570	205	7	basal	basal	ADJ
admet-1570	205	8	background	background	NOUN
admet-1570	205	9	subtracted	subtract	VERB
admet-1570	205	10	.	.	PUNCT
admet-1570	206	1	levitt	levitt	PROPN
admet-1570	206	2	and	and	CCONJ
admet-1570	206	3	colleagues	colleague	NOUN
admet-1570	207	1	[	[	X
admet-1570	207	2	35,36	35,36	NUM
admet-1570	207	3	]	]	PUNCT
admet-1570	207	4	have	have	AUX
admet-1570	207	5	reported	report	VERB
admet-1570	207	6	a	a	DET
admet-1570	207	7	detailed	detailed	ADJ
admet-1570	207	8	analysis	analysis	NOUN
admet-1570	207	9	of	of	ADP
admet-1570	207	10	the	the	DET
admet-1570	207	11	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	207	12	of	of	ADP
admet-1570	207	13	amylase	amylase	NOUN
admet-1570	207	14	in	in	ADP
admet-1570	207	15	the	the	DET
admet-1570	207	16	baboon	baboon	NOUN
admet-1570	207	17	.	.	PUNCT
admet-1570	208	1	they	they	PRON
admet-1570	208	2	determined	determine	VERB
admet-1570	208	3	the	the	DET
admet-1570	208	4	plasma	plasma	NOUN
admet-1570	208	5	kinetics	kinetic	NOUN
admet-1570	208	6	of	of	ADP
admet-1570	208	7	enzyme	enzyme	NOUN
admet-1570	208	8	activity	activity	NOUN
admet-1570	208	9	following	follow	VERB
admet-1570	208	10	a	a	DET
admet-1570	208	11	bolus	bolus	NOUN
admet-1570	208	12	iv	iv	NUM
admet-1570	208	13	injection	injection	NOUN
admet-1570	208	14	of	of	ADP
admet-1570	208	15	either	either	CCONJ
admet-1570	208	16	salivary	salivary	ADJ
admet-1570	208	17	or	or	CCONJ
admet-1570	208	18	pancreatic	pancreatic	ADJ
admet-1570	208	19	amylase	amylase	NOUN
admet-1570	208	20	,	,	PUNCT
admet-1570	208	21	both	both	PRON
admet-1570	208	22	of	of	ADP
admet-1570	208	23	which	which	PRON
admet-1570	208	24	were	be	AUX
admet-1570	208	25	rapidly	rapidly	ADV
admet-1570	208	26	cleared	clear	VERB
admet-1570	208	27	with	with	ADP
admet-1570	208	28	nearly	nearly	ADV
admet-1570	208	29	identical	identical	ADJ
admet-1570	208	30	kinetics	kinetic	NOUN
admet-1570	208	31	and	and	CCONJ
admet-1570	208	32	could	could	AUX
admet-1570	208	33	be	be	AUX
admet-1570	208	34	admet	admet	PROPN
admet-1570	208	35	&	&	CCONJ
admet-1570	208	36	dmpk	dmpk	PROPN
admet-1570	208	37	11(1	11(1	NUM
admet-1570	208	38	)	)	PUNCT
admet-1570	208	39	(	(	PUNCT
admet-1570	208	40	2023	2023	NUM
admet-1570	208	41	)	)	PUNCT
admet-1570	208	42	57	57	NUM
admet-1570	208	43	-	-	SYM
admet-1570	208	44	80	80	NUM
admet-1570	208	45	protein	protein	NOUN
admet-1570	208	46	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	208	47	model	model	NOUN
admet-1570	208	48	doi	doi	NOUN
admet-1570	208	49	:	:	PUNCT
admet-1570	208	50	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	208	51	67	67	NUM
admet-1570	208	52	described	describe	VERB
admet-1570	208	53	by	by	ADP
admet-1570	208	54	a	a	DET
admet-1570	208	55	single	single	ADJ
admet-1570	208	56	exponential	exponential	NOUN
admet-1570	208	57	with	with	ADP
admet-1570	208	58	a	a	DET
admet-1570	208	59	tm	tm	NOUN
admet-1570	208	60	of	of	ADP
admet-1570	208	61	about	about	ADV
admet-1570	208	62	100	100	NUM
admet-1570	208	63	min	min	NOUN
admet-1570	208	64	.	.	PROPN
admet-1570	208	65	complicated	complicated	ADJ
admet-1570	208	66	pk	pk	NOUN
admet-1570	208	67	modeling	modeling	NOUN
admet-1570	208	68	is	be	AUX
admet-1570	208	69	superfluous	superfluous	ADJ
admet-1570	208	70	for	for	ADP
admet-1570	208	71	proteins	protein	NOUN
admet-1570	208	72	with	with	ADP
admet-1570	208	73	tm	tm	PRON
admet-1570	208	74	much	much	ADV
admet-1570	208	75	shorter	short	ADJ
admet-1570	208	76	than	than	ADP
admet-1570	208	77	the	the	DET
admet-1570	208	78	plasma	plasma	NOUN
admet-1570	208	79	-	-	PUNCT
admet-1570	208	80	tissue	tissue	NOUN
admet-1570	208	81	exchange	exchange	NOUN
admet-1570	208	82	time	time	NOUN
admet-1570	208	83	constants	constant	NOUN
admet-1570	208	84	(	(	PUNCT
admet-1570	208	85	tp1	tp1	NOUN
admet-1570	208	86	,	,	PUNCT
admet-1570	208	87	tp2	tp2	PROPN
admet-1570	208	88	,	,	PUNCT
admet-1570	208	89	tt1	tt1	PROPN
admet-1570	208	90	,	,	PUNCT
admet-1570	208	91	tt2	tt2	PROPN
admet-1570	208	92	)	)	PUNCT
admet-1570	208	93	because	because	SCONJ
admet-1570	208	94	these	these	DET
admet-1570	208	95	proteins	protein	NOUN
admet-1570	208	96	,	,	PUNCT
admet-1570	208	97	effectively	effectively	ADV
admet-1570	208	98	,	,	PUNCT
admet-1570	208	99	are	be	AUX
admet-1570	208	100	limited	limit	VERB
admet-1570	208	101	to	to	ADP
admet-1570	208	102	the	the	DET
admet-1570	208	103	plasma	plasma	NOUN
admet-1570	208	104	space	space	NOUN
admet-1570	208	105	and	and	CCONJ
admet-1570	208	106	should	should	AUX
admet-1570	208	107	have	have	VERB
admet-1570	208	108	one	one	NUM
admet-1570	208	109	compartment	compartment	NOUN
admet-1570	208	110	,	,	PUNCT
admet-1570	208	111	single	single	ADJ
admet-1570	208	112	exponential	exponential	NOUN
admet-1570	208	113	,	,	PUNCT
admet-1570	208	114	kinetics	kinetic	NOUN
admet-1570	208	115	with	with	ADP
admet-1570	208	116	tm	tm	PROPN
admet-1570	208	117	equal	equal	ADJ
admet-1570	208	118	to	to	ADP
admet-1570	208	119	1	1	NUM
admet-1570	208	120	/	/	SYM
admet-1570	208	121	slope	slope	NOUN
admet-1570	208	122	of	of	ADP
admet-1570	208	123	the	the	DET
admet-1570	208	124	straight	straight	ADJ
admet-1570	208	125	line	line	NOUN
admet-1570	208	126	in	in	ADP
admet-1570	208	127	the	the	DET
admet-1570	208	128	log	log	NOUN
admet-1570	208	129	plot	plot	NOUN
admet-1570	208	130	.	.	PUNCT
admet-1570	209	1	since	since	SCONJ
admet-1570	209	2	tm	tm	PROPN
admet-1570	209	3	is	be	AUX
admet-1570	209	4	uniquely	uniquely	ADV
admet-1570	209	5	determined	determine	VERB
admet-1570	209	6	by	by	ADP
admet-1570	209	7	the	the	DET
admet-1570	209	8	plasma	plasma	NOUN
admet-1570	209	9	volume	volume	NOUN
admet-1570	209	10	and	and	CCONJ
admet-1570	209	11	the	the	DET
admet-1570	209	12	clearance	clearance	NOUN
admet-1570	209	13	(	(	PUNCT
admet-1570	209	14	eq	eq	NOUN
admet-1570	209	15	.	.	PROPN
admet-1570	209	16	2	2	NUM
admet-1570	209	17	)	)	PUNCT
admet-1570	209	18	,	,	PUNCT
admet-1570	209	19	the	the	DET
admet-1570	209	20	clearance	clearance	NOUN
admet-1570	209	21	is	be	AUX
admet-1570	209	22	the	the	DET
admet-1570	209	23	only	only	ADJ
admet-1570	209	24	adjustable	adjustable	ADJ
admet-1570	209	25	parameter	parameter	NOUN
admet-1570	209	26	.	.	PUNCT
admet-1570	210	1	however	however	ADV
admet-1570	210	2	,	,	PUNCT
admet-1570	210	3	it	it	PRON
admet-1570	210	4	is	be	AUX
admet-1570	210	5	of	of	ADP
admet-1570	210	6	interest	interest	NOUN
admet-1570	210	7	to	to	PART
admet-1570	210	8	check	check	VERB
admet-1570	210	9	whether	whether	SCONJ
admet-1570	210	10	a	a	DET
admet-1570	210	11	single	single	ADJ
admet-1570	210	12	exponential	exponential	NOUN
admet-1570	210	13	is	be	AUX
admet-1570	210	14	consistent	consistent	ADJ
admet-1570	210	15	with	with	ADP
admet-1570	210	16	our	our	PRON
admet-1570	210	17	protein	protein	NOUN
admet-1570	210	18	model	model	NOUN
admet-1570	210	19	.	.	PUNCT
admet-1570	211	1	figure	figure	NOUN
admet-1570	211	2	5	5	NUM
admet-1570	211	3	shows	show	VERB
admet-1570	211	4	the	the	DET
admet-1570	211	5	model	model	NOUN
admet-1570	211	6	fit	fit	ADJ
admet-1570	211	7	assuming	assume	VERB
admet-1570	211	8	amylase	amylase	NOUN
admet-1570	211	9	f1	f1	NOUN
admet-1570	211	10	and	and	CCONJ
admet-1570	211	11	f2	f2	PROPN
admet-1570	211	12	equal	equal	ADJ
admet-1570	211	13	to	to	ADP
admet-1570	211	14	those	those	PRON
admet-1570	211	15	of	of	ADP
admet-1570	211	16	albumin	albumin	NOUN
admet-1570	211	17	,	,	PUNCT
admet-1570	211	18	which	which	PRON
admet-1570	211	19	has	have	VERB
admet-1570	211	20	a	a	DET
admet-1570	211	21	similar	similar	ADJ
admet-1570	211	22	molecular	molecular	ADJ
admet-1570	211	23	weight	weight	NOUN
admet-1570	211	24	and	and	CCONJ
admet-1570	211	25	l1	l1	PROPN
admet-1570	211	26	and	and	CCONJ
admet-1570	211	27	l2	l2	NOUN
admet-1570	211	28	for	for	ADP
admet-1570	211	29	the	the	DET
admet-1570	211	30	baboon	baboon	NOUN
admet-1570	211	31	assumed	assume	VERB
admet-1570	211	32	identical	identical	ADJ
admet-1570	211	33	to	to	ADP
admet-1570	211	34	the	the	DET
admet-1570	211	35	human	human	ADJ
admet-1570	211	36	(	(	PUNCT
admet-1570	211	37	table	table	NOUN
admet-1570	211	38	2	2	NUM
admet-1570	211	39	)	)	PUNCT
admet-1570	211	40	.	.	PUNCT
admet-1570	212	1	only	only	ADV
admet-1570	212	2	the	the	DET
admet-1570	212	3	last	last	ADJ
admet-1570	212	4	experimental	experimental	ADJ
admet-1570	212	5	data	datum	NOUN
admet-1570	212	6	point	point	NOUN
admet-1570	212	7	deviated	deviate	VERB
admet-1570	212	8	from	from	ADP
admet-1570	212	9	this	this	DET
admet-1570	212	10	model	model	NOUN
admet-1570	212	11	result	result	NOUN
admet-1570	212	12	.	.	PUNCT
admet-1570	213	1	since	since	SCONJ
admet-1570	213	2	the	the	DET
admet-1570	213	3	experimental	experimental	ADJ
admet-1570	213	4	data	datum	NOUN
admet-1570	213	5	is	be	AUX
admet-1570	213	6	for	for	ADP
admet-1570	213	7	the	the	DET
admet-1570	213	8	“	"	PUNCT
admet-1570	213	9	excess	excess	ADJ
admet-1570	213	10	”	"	PUNCT
admet-1570	213	11	amylase	amylase	NOUN
admet-1570	213	12	above	above	ADP
admet-1570	213	13	the	the	DET
admet-1570	213	14	initial	initial	ADJ
admet-1570	213	15	basal	basal	NOUN
admet-1570	213	16	value	value	NOUN
admet-1570	213	17	,	,	PUNCT
admet-1570	213	18	just	just	ADV
admet-1570	213	19	a	a	DET
admet-1570	213	20	small	small	ADJ
admet-1570	213	21	drift	drift	NOUN
admet-1570	213	22	(	(	PUNCT
admet-1570	213	23	≈	≈	PROPN
admet-1570	213	24	2	2	NUM
admet-1570	213	25	units	unit	NOUN
admet-1570	213	26	/	/	SYM
admet-1570	213	27	ml	ml	NOUN
admet-1570	213	28	)	)	PUNCT
admet-1570	213	29	in	in	ADP
admet-1570	213	30	basal	basal	ADJ
admet-1570	213	31	amylase	amylase	NOUN
admet-1570	213	32	could	could	AUX
admet-1570	213	33	account	account	VERB
admet-1570	213	34	for	for	ADP
admet-1570	213	35	this	this	DET
admet-1570	213	36	small	small	ADJ
admet-1570	213	37	deviation	deviation	NOUN
admet-1570	213	38	.	.	PUNCT
admet-1570	214	1	or	or	CCONJ
admet-1570	214	2	,	,	PUNCT
admet-1570	214	3	if	if	SCONJ
admet-1570	214	4	the	the	DET
admet-1570	214	5	data	datum	NOUN
admet-1570	214	6	are	be	AUX
admet-1570	214	7	correct	correct	ADJ
admet-1570	214	8	,	,	PUNCT
admet-1570	214	9	it	it	PRON
admet-1570	214	10	would	would	AUX
admet-1570	214	11	suggest	suggest	VERB
admet-1570	214	12	that	that	SCONJ
admet-1570	214	13	the	the	DET
admet-1570	214	14	tissue	tissue	NOUN
admet-1570	214	15	-	-	PUNCT
admet-1570	214	16	plasma	plasma	NOUN
admet-1570	214	17	exchange	exchange	NOUN
admet-1570	214	18	of	of	ADP
admet-1570	214	19	amylase	amylase	NOUN
admet-1570	214	20	is	be	AUX
admet-1570	214	21	significantly	significantly	ADV
admet-1570	214	22	slower	slow	ADJ
admet-1570	214	23	than	than	ADP
admet-1570	214	24	albumin	albumin	ADJ
admet-1570	214	25	.	.	PUNCT
admet-1570	215	1	note	note	NOUN
admet-1570	215	2	,	,	PUNCT
admet-1570	215	3	the	the	DET
admet-1570	215	4	values	value	NOUN
admet-1570	215	5	of	of	ADP
admet-1570	215	6	the	the	DET
admet-1570	215	7	parameters	parameter	NOUN
admet-1570	215	8	f1	f1	NOUN
admet-1570	215	9	,	,	PUNCT
admet-1570	215	10	f2	f2	PROPN
admet-1570	215	11	,	,	PUNCT
admet-1570	215	12	l1	l1	PROPN
admet-1570	215	13	,	,	PUNCT
admet-1570	215	14	and	and	CCONJ
admet-1570	215	15	l2	l2	NOUN
admet-1570	215	16	listed	list	VERB
admet-1570	215	17	in	in	ADP
admet-1570	215	18	table	table	NOUN
admet-1570	215	19	2	2	NUM
admet-1570	215	20	for	for	ADP
admet-1570	215	21	amylase	amylase	NOUN
admet-1570	215	22	and	and	CCONJ
admet-1570	215	23	lipase	lipase	NOUN
admet-1570	215	24	only	only	ADV
admet-1570	215	25	indicate	indicate	VERB
admet-1570	215	26	that	that	SCONJ
admet-1570	215	27	they	they	PRON
admet-1570	215	28	are	be	AUX
admet-1570	215	29	compatible	compatible	ADJ
admet-1570	215	30	with	with	ADP
admet-1570	215	31	the	the	DET
admet-1570	215	32	plasma	plasma	NOUN
admet-1570	215	33	pk	pk	NOUN
admet-1570	215	34	,	,	PUNCT
admet-1570	215	35	but	but	CCONJ
admet-1570	215	36	they	they	PRON
admet-1570	215	37	were	be	AUX
admet-1570	215	38	not	not	PART
admet-1570	215	39	directly	directly	ADV
admet-1570	215	40	determined	determine	VERB
admet-1570	215	41	because	because	SCONJ
admet-1570	215	42	of	of	ADP
admet-1570	215	43	the	the	DET
admet-1570	215	44	short	short	ADJ
admet-1570	215	45	metabolic	metabolic	PROPN
admet-1570	215	46	time	time	NOUN
admet-1570	215	47	constant	constant	ADJ
admet-1570	215	48	.	.	PUNCT
admet-1570	216	1	although	although	SCONJ
admet-1570	216	2	there	there	PRON
admet-1570	216	3	are	be	VERB
admet-1570	216	4	no	no	DET
admet-1570	216	5	equivalent	equivalent	ADJ
admet-1570	216	6	large	large	ADJ
admet-1570	216	7	animal	animal	NOUN
admet-1570	216	8	kinetic	kinetic	NOUN
admet-1570	216	9	studies	study	NOUN
admet-1570	216	10	of	of	ADP
admet-1570	216	11	lipase	lipase	NOUN
admet-1570	216	12	,	,	PUNCT
admet-1570	216	13	we	we	PRON
admet-1570	216	14	have	have	AUX
admet-1570	216	15	assumed	assume	VERB
admet-1570	216	16	identical	identical	ADJ
admet-1570	216	17	kinetics	kinetic	NOUN
admet-1570	216	18	for	for	ADP
admet-1570	216	19	lipase	lipase	NOUN
admet-1570	216	20	in	in	ADP
admet-1570	216	21	table	table	NOUN
admet-1570	216	22	1	1	NUM
admet-1570	216	23	because	because	SCONJ
admet-1570	216	24	of	of	ADP
admet-1570	216	25	the	the	DET
admet-1570	216	26	nearly	nearly	ADV
admet-1570	216	27	identical	identical	ADJ
admet-1570	216	28	lipase	lipase	NOUN
admet-1570	216	29	and	and	CCONJ
admet-1570	216	30	amylase	amylase	NOUN
admet-1570	216	31	kinetics	kinetic	NOUN
admet-1570	216	32	in	in	ADP
admet-1570	216	33	the	the	DET
admet-1570	216	34	rat	rat	NOUN
admet-1570	216	35	[	[	X
admet-1570	216	36	33	33	NUM
admet-1570	216	37	]	]	PUNCT
admet-1570	216	38	.	.	PUNCT
admet-1570	217	1	alanine	alanine	NOUN
admet-1570	217	2	transaminase	transaminase	NOUN
admet-1570	217	3	(	(	PUNCT
admet-1570	217	4	alt	alt	NOUN
admet-1570	217	5	)	)	PUNCT
admet-1570	217	6	alanine	alanine	NOUN
admet-1570	217	7	transaminase	transaminase	NOUN
admet-1570	217	8	,	,	PUNCT
admet-1570	217	9	also	also	ADV
admet-1570	217	10	known	know	VERB
admet-1570	217	11	as	as	ADP
admet-1570	217	12	alanine	alanine	NOUN
admet-1570	217	13	aminotransferase	aminotransferase	NOUN
admet-1570	217	14	or	or	CCONJ
admet-1570	217	15	glutamic	glutamic	ADJ
admet-1570	217	16	pyruvate	pyruvate	NOUN
admet-1570	217	17	transaminase	transaminase	NOUN
admet-1570	217	18	,	,	PUNCT
admet-1570	217	19	is	be	AUX
admet-1570	217	20	released	release	VERB
admet-1570	217	21	from	from	ADP
admet-1570	217	22	a	a	DET
admet-1570	217	23	variety	variety	NOUN
admet-1570	217	24	of	of	ADP
admet-1570	217	25	tissues	tissue	NOUN
admet-1570	217	26	under	under	ADP
admet-1570	217	27	pathological	pathological	ADJ
admet-1570	217	28	conditions	condition	NOUN
admet-1570	217	29	.	.	PUNCT
admet-1570	218	1	its	its	PRON
admet-1570	218	2	primary	primary	ADJ
admet-1570	218	3	site	site	NOUN
admet-1570	218	4	of	of	ADP
admet-1570	218	5	elimination	elimination	NOUN
admet-1570	218	6	is	be	AUX
admet-1570	218	7	probably	probably	ADV
admet-1570	218	8	the	the	DET
admet-1570	218	9	liver	liver	NOUN
admet-1570	218	10	.	.	PUNCT
admet-1570	219	1	at	at	ADV
admet-1570	219	2	least	least	ADV
admet-1570	219	3	three	three	NUM
admet-1570	219	4	different	different	ADJ
admet-1570	219	5	liver	liver	NOUN
admet-1570	219	6	systems	system	NOUN
admet-1570	219	7	are	be	AUX
admet-1570	219	8	involved	involve	VERB
admet-1570	219	9	in	in	ADP
admet-1570	219	10	protein	protein	NOUN
admet-1570	219	11	catabolism	catabolism	NOUN
admet-1570	219	12	:	:	PUNCT
admet-1570	219	13	the	the	DET
admet-1570	219	14	sinusoidal	sinusoidal	NOUN
admet-1570	219	15	cells	cell	NOUN
admet-1570	219	16	,	,	PUNCT
admet-1570	219	17	the	the	DET
admet-1570	219	18	kupffer	kupffer	NOUN
admet-1570	219	19	cells	cell	NOUN
admet-1570	219	20	and	and	CCONJ
admet-1570	219	21	the	the	DET
admet-1570	219	22	asialoglycoprotein	asialoglycoprotein	ADJ
admet-1570	219	23	receptor	receptor	NOUN
admet-1570	219	24	(	(	PUNCT
admet-1570	219	25	see	see	VERB
admet-1570	219	26	below	below	ADV
admet-1570	219	27	)	)	PUNCT
admet-1570	219	28	.	.	PUNCT
admet-1570	220	1	kupffer	kupffer	NOUN
admet-1570	220	2	cells	cell	NOUN
admet-1570	220	3	are	be	AUX
admet-1570	220	4	macrophages	macrophage	NOUN
admet-1570	220	5	that	that	PRON
admet-1570	220	6	line	line	VERB
admet-1570	220	7	the	the	DET
admet-1570	220	8	surface	surface	NOUN
admet-1570	220	9	of	of	ADP
admet-1570	220	10	the	the	DET
admet-1570	220	11	sinusoids	sinusoid	NOUN
admet-1570	220	12	[	[	X
admet-1570	220	13	37	37	NUM
admet-1570	220	14	]	]	PUNCT
admet-1570	220	15	and	and	CCONJ
admet-1570	220	16	their	their	PRON
admet-1570	220	17	metabolic	metabolic	NOUN
admet-1570	220	18	activity	activity	NOUN
admet-1570	220	19	for	for	ADP
admet-1570	220	20	different	different	ADJ
admet-1570	220	21	enzymes	enzyme	NOUN
admet-1570	220	22	can	can	AUX
admet-1570	220	23	be	be	AUX
admet-1570	220	24	quantitated	quantitate	VERB
admet-1570	220	25	by	by	ADP
admet-1570	220	26	competition	competition	NOUN
admet-1570	220	27	experiments	experiment	NOUN
admet-1570	220	28	[	[	X
admet-1570	220	29	38	38	NUM
admet-1570	220	30	]	]	PUNCT
admet-1570	220	31	.	.	PUNCT
admet-1570	221	1	because	because	SCONJ
admet-1570	221	2	the	the	DET
admet-1570	221	3	kupffer	kupffer	NOUN
admet-1570	221	4	cells	cell	NOUN
admet-1570	221	5	usually	usually	ADV
admet-1570	221	6	have	have	VERB
admet-1570	221	7	higher	high	ADJ
admet-1570	221	8	rates	rate	NOUN
admet-1570	221	9	of	of	ADP
admet-1570	221	10	metabolism	metabolism	NOUN
admet-1570	221	11	than	than	ADP
admet-1570	221	12	the	the	DET
admet-1570	221	13	sinusoidal	sinusoidal	NOUN
admet-1570	221	14	cells	cell	NOUN
admet-1570	221	15	,	,	PUNCT
admet-1570	221	16	the	the	DET
admet-1570	221	17	proteins	protein	NOUN
admet-1570	221	18	they	they	PRON
admet-1570	221	19	catabolize	catabolize	VERB
admet-1570	221	20	usually	usually	ADV
admet-1570	221	21	have	have	VERB
admet-1570	221	22	shorter	short	ADJ
admet-1570	221	23	time	time	NOUN
admet-1570	221	24	constants	constant	NOUN
admet-1570	221	25	.	.	PUNCT
admet-1570	222	1	alt	alt	VERB
admet-1570	222	2	is	be	AUX
admet-1570	222	3	not	not	PART
admet-1570	222	4	metabolized	metabolize	VERB
admet-1570	222	5	by	by	ADP
admet-1570	222	6	kupffer	kupffer	NOUN
admet-1570	222	7	cells	cell	NOUN
admet-1570	222	8	,	,	PUNCT
admet-1570	222	9	consistent	consistent	ADJ
admet-1570	222	10	with	with	ADP
admet-1570	222	11	its	its	PRON
admet-1570	222	12	relatively	relatively	ADV
admet-1570	222	13	long	long	ADJ
admet-1570	222	14	lifetime	lifetime	NOUN
admet-1570	223	1	[	[	X
admet-1570	223	2	38	38	NUM
admet-1570	223	3	]	]	PUNCT
admet-1570	223	4	.	.	PUNCT
admet-1570	224	1	figure	figure	NOUN
admet-1570	224	2	6	6	NUM
admet-1570	224	3	.	.	PUNCT
admet-1570	224	4	comparison	comparison	NOUN
admet-1570	224	5	of	of	ADP
admet-1570	224	6	pk	pk	NOUN
admet-1570	224	7	physiological	physiological	ADJ
admet-1570	224	8	protein	protein	NOUN
admet-1570	224	9	model	model	NOUN
admet-1570	224	10	(	(	PUNCT
admet-1570	224	11	line	line	NOUN
admet-1570	224	12	)	)	PUNCT
admet-1570	224	13	for	for	ADP
admet-1570	224	14	alt	alt	VERB
admet-1570	224	15	bolus	bolus	NOUN
admet-1570	224	16	iv	iv	NUM
admet-1570	224	17	injection	injection	NOUN
admet-1570	224	18	versus	versus	ADP
admet-1570	224	19	experimental	experimental	ADJ
admet-1570	224	20	data	datum	NOUN
admet-1570	224	21	(	(	PUNCT
admet-1570	224	22	solid	solid	ADJ
admet-1570	224	23	circles	circle	NOUN
admet-1570	224	24	)	)	PUNCT
admet-1570	224	25	in	in	ADP
admet-1570	224	26	dog	dog	NOUN
admet-1570	224	27	.	.	PUNCT
admet-1570	225	1	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	226	1	d.g	d.g	PROPN
admet-1570	226	2	.	.	PROPN
admet-1570	226	3	levitt	levitt	PROPN
admet-1570	226	4	and	and	CCONJ
admet-1570	226	5	m.d	m.d	PROPN
admet-1570	226	6	.	.	PROPN
admet-1570	226	7	levitt	levitt	PROPN
admet-1570	226	8	admet	admet	PROPN
admet-1570	226	9	&	&	CCONJ
admet-1570	226	10	dmpk	dmpk	PROPN
admet-1570	226	11	11(1	11(1	NUM
admet-1570	226	12	)	)	PUNCT
admet-1570	226	13	(	(	PUNCT
admet-1570	226	14	2023	2023	NUM
admet-1570	226	15	)	)	PUNCT
admet-1570	226	16	57	57	NUM
admet-1570	226	17	-	-	SYM
admet-1570	226	18	80	80	NUM
admet-1570	226	19	68	68	NUM
admet-1570	226	20	fleisher	fleisher	NOUN
admet-1570	226	21	and	and	CCONJ
admet-1570	226	22	wakim	wakim	NOUN
admet-1570	227	1	[	[	X
admet-1570	227	2	39	39	NUM
admet-1570	227	3	]	]	PUNCT
admet-1570	227	4	determined	determine	VERB
admet-1570	227	5	the	the	DET
admet-1570	227	6	dog	dog	NOUN
admet-1570	227	7	disappearance	disappearance	NOUN
admet-1570	227	8	kinetics	kinetic	NOUN
admet-1570	227	9	of	of	ADP
admet-1570	227	10	iv	iv	NOUN
admet-1570	227	11	injections	injection	NOUN
admet-1570	227	12	of	of	ADP
admet-1570	227	13	alt	alt	ADV
admet-1570	227	14	purified	purified	ADJ
admet-1570	227	15	from	from	ADP
admet-1570	227	16	either	either	PRON
admet-1570	227	17	dog	dog	NOUN
admet-1570	227	18	liver	liver	NOUN
admet-1570	227	19	or	or	CCONJ
admet-1570	227	20	heart	heart	NOUN
admet-1570	227	21	(	(	PUNCT
admet-1570	227	22	no	no	DET
admet-1570	227	23	significant	significant	ADJ
admet-1570	227	24	differences	difference	NOUN
admet-1570	227	25	)	)	PUNCT
admet-1570	227	26	.	.	PUNCT
admet-1570	228	1	importantly	importantly	ADV
admet-1570	228	2	,	,	PUNCT
admet-1570	228	3	they	they	PRON
admet-1570	228	4	also	also	ADV
admet-1570	228	5	reported	report	VERB
admet-1570	228	6	simultaneous	simultaneous	ADJ
admet-1570	228	7	measurements	measurement	NOUN
admet-1570	228	8	of	of	ADP
admet-1570	228	9	thoracic	thoracic	NOUN
admet-1570	228	10	duct	duct	NOUN
admet-1570	228	11	lymph	lymph	NOUN
admet-1570	228	12	alt	alt	VERB
admet-1570	228	13	concentrations	concentration	NOUN
admet-1570	228	14	,	,	PUNCT
admet-1570	228	15	which	which	PRON
admet-1570	228	16	,	,	PUNCT
admet-1570	228	17	as	as	SCONJ
admet-1570	228	18	discussed	discuss	VERB
admet-1570	228	19	above	above	ADV
admet-1570	228	20	,	,	PUNCT
admet-1570	228	21	can	can	AUX
admet-1570	228	22	be	be	AUX
admet-1570	228	23	used	use	VERB
admet-1570	228	24	to	to	PART
admet-1570	228	25	estimate	estimate	VERB
admet-1570	228	26	the	the	DET
admet-1570	228	27	tissue	tissue	NOUN
admet-1570	228	28	volumes	volume	NOUN
admet-1570	228	29	.	.	PUNCT
admet-1570	229	1	using	use	VERB
admet-1570	229	2	these	these	DET
admet-1570	229	3	data	datum	NOUN
admet-1570	229	4	,	,	PUNCT
admet-1570	229	5	we	we	PRON
admet-1570	229	6	estimated	estimate	VERB
admet-1570	229	7	the	the	DET
admet-1570	229	8	dog	dog	NOUN
admet-1570	229	9	values	value	NOUN
admet-1570	229	10	of	of	ADP
admet-1570	229	11	tissue	tissue	NOUN
admet-1570	229	12	volumes	volume	NOUN
admet-1570	229	13	of	of	ADP
admet-1570	229	14	v1	v1	NOUN
admet-1570	229	15	/	/	SYM
admet-1570	229	16	vp	vp	NOUN
admet-1570	229	17	=	=	SYM
admet-1570	229	18	1.0	1.0	NUM
admet-1570	229	19	and	and	CCONJ
admet-1570	229	20	v2	v2	PROPN
admet-1570	229	21	/	/	SYM
admet-1570	229	22	vp	vp	NOUN
admet-1570	229	23	=	=	SYM
admet-1570	229	24	0.3	0.3	NUM
admet-1570	229	25	,	,	PUNCT
admet-1570	229	26	differing	differ	VERB
admet-1570	229	27	slightly	slightly	ADV
admet-1570	229	28	from	from	ADP
admet-1570	229	29	the	the	DET
admet-1570	229	30	values	value	NOUN
admet-1570	229	31	determined	determine	VERB
admet-1570	229	32	above	above	ADV
admet-1570	229	33	for	for	ADP
admet-1570	229	34	the	the	DET
admet-1570	229	35	human	human	NOUN
admet-1570	229	36	.	.	PUNCT
admet-1570	230	1	these	these	DET
admet-1570	230	2	values	value	NOUN
admet-1570	230	3	then	then	ADV
admet-1570	230	4	allow	allow	VERB
admet-1570	230	5	us	we	PRON
admet-1570	230	6	to	to	PART
admet-1570	230	7	relate	relate	VERB
admet-1570	230	8	the	the	DET
admet-1570	230	9	compartmental	compartmental	ADJ
admet-1570	230	10	model	model	NOUN
admet-1570	230	11	time	time	NOUN
admet-1570	230	12	constants	constant	NOUN
admet-1570	230	13	to	to	ADP
admet-1570	230	14	the	the	DET
admet-1570	230	15	filtration	filtration	NOUN
admet-1570	230	16	coefficients	coefficient	NOUN
admet-1570	230	17	and	and	CCONJ
admet-1570	230	18	lymph	lymph	NOUN
admet-1570	230	19	flows	flow	NOUN
admet-1570	230	20	using	use	VERB
admet-1570	230	21	eq	eq	ADP
admet-1570	230	22	.	.	PROPN
admet-1570	230	23	2	2	X
admet-1570	230	24	.	.	X
admet-1570	230	25	figure	figure	NOUN
admet-1570	230	26	6	6	NUM
admet-1570	230	27	shows	show	VERB
admet-1570	230	28	the	the	DET
admet-1570	230	29	good	good	ADJ
admet-1570	230	30	fit	fit	NOUN
admet-1570	230	31	of	of	ADP
admet-1570	230	32	the	the	DET
admet-1570	230	33	protein	protein	NOUN
admet-1570	230	34	model	model	NOUN
admet-1570	230	35	to	to	ADP
admet-1570	230	36	the	the	DET
admet-1570	230	37	plasma	plasma	NOUN
admet-1570	230	38	concentration	concentration	NOUN
admet-1570	230	39	following	follow	VERB
admet-1570	230	40	the	the	DET
admet-1570	230	41	iv	iv	NUM
admet-1570	230	42	bolus	bolus	ADJ
admet-1570	230	43	injection	injection	NOUN
admet-1570	230	44	,	,	PUNCT
admet-1570	230	45	using	use	VERB
admet-1570	230	46	the	the	DET
admet-1570	230	47	pk	pk	NOUN
admet-1570	230	48	data	datum	NOUN
admet-1570	230	49	listed	list	VERB
admet-1570	230	50	in	in	ADP
admet-1570	230	51	tables	table	NOUN
admet-1570	230	52	1	1	NUM
admet-1570	230	53	and	and	CCONJ
admet-1570	230	54	2	2	NUM
admet-1570	230	55	.	.	X
admet-1570	231	1	the	the	DET
admet-1570	231	2	metabolic	metabolic	ADJ
admet-1570	231	3	time	time	NOUN
admet-1570	231	4	constant	constant	ADJ
admet-1570	231	5	(	(	PUNCT
admet-1570	231	6	tm	tm	NOUN
admet-1570	231	7	)	)	PUNCT
admet-1570	231	8	is	be	AUX
admet-1570	231	9	2949	2949	NUM
admet-1570	231	10	min	min	NOUN
admet-1570	231	11	(	(	PUNCT
admet-1570	231	12	2	2	NUM
admet-1570	231	13	days	day	NOUN
admet-1570	231	14	)	)	PUNCT
admet-1570	231	15	,	,	PUNCT
admet-1570	231	16	5.5	5.5	NUM
admet-1570	231	17	fold	fold	VERB
admet-1570	231	18	faster	fast	ADV
admet-1570	231	19	than	than	ADP
admet-1570	231	20	albumin	albumin	ADJ
admet-1570	231	21	.	.	PUNCT
admet-1570	232	1	the	the	DET
admet-1570	232	2	corresponding	correspond	VERB
admet-1570	232	3	f1=0.53	f1=0.53	NOUN
admet-1570	232	4	,	,	PUNCT
admet-1570	232	5	f2=0.535	f2=0.535	PROPN
admet-1570	232	6	.	.	PUNCT
admet-1570	233	1	the	the	DET
admet-1570	233	2	estimated	estimate	VERB
admet-1570	233	3	lymph	lymph	NOUN
admet-1570	233	4	flows	flow	NOUN
admet-1570	233	5	are	be	AUX
admet-1570	233	6	l1	l1	PROPN
admet-1570	233	7	=	=	PROPN
admet-1570	233	8	1.2	1.2	NUM
admet-1570	233	9	and	and	CCONJ
admet-1570	233	10	l2	l2	NOUN
admet-1570	233	11	=	=	NOUN
admet-1570	233	12	2.7	2.7	NUM
admet-1570	233	13	,	,	PUNCT
admet-1570	233	14	for	for	ADP
admet-1570	233	15	a	a	DET
admet-1570	233	16	total	total	ADJ
admet-1570	233	17	lymph	lymph	NOUN
admet-1570	233	18	flow	flow	NOUN
admet-1570	233	19	=	=	SYM
admet-1570	233	20	3.9	3.9	NUM
admet-1570	233	21	ml	ml	NOUN
admet-1570	233	22	/	/	SYM
admet-1570	233	23	min	min	NOUN
admet-1570	233	24	,	,	PUNCT
admet-1570	233	25	similar	similar	ADJ
admet-1570	233	26	to	to	ADP
admet-1570	233	27	the	the	DET
admet-1570	233	28	3.5	3.5	NUM
admet-1570	233	29	ml	ml	NOUN
admet-1570	233	30	/	/	SYM
admet-1570	233	31	min	min	NOUN
admet-1570	233	32	value	value	NOUN
admet-1570	233	33	reported	report	VERB
admet-1570	233	34	in	in	ADP
admet-1570	233	35	resting	rest	VERB
admet-1570	233	36	conscious	conscious	ADJ
admet-1570	233	37	dogs	dog	NOUN
admet-1570	233	38	[	[	X
admet-1570	233	39	40	40	NUM
admet-1570	233	40	]	]	PUNCT
admet-1570	233	41	.	.	PUNCT
admet-1570	234	1	(	(	PUNCT
admet-1570	234	2	note	note	VERB
admet-1570	234	3	,	,	PUNCT
admet-1570	234	4	all	all	DET
admet-1570	234	5	values	value	NOUN
admet-1570	234	6	reported	report	VERB
admet-1570	234	7	in	in	ADP
admet-1570	234	8	this	this	DET
admet-1570	234	9	review	review	NOUN
admet-1570	234	10	have	have	AUX
admet-1570	234	11	been	be	AUX
admet-1570	234	12	extrapolated	extrapolate	VERB
admet-1570	234	13	to	to	ADP
admet-1570	234	14	the	the	DET
admet-1570	234	15	70	70	NUM
admet-1570	234	16	kg	kg	NOUN
admet-1570	234	17	human	human	NOUN
admet-1570	234	18	)	)	PUNCT
admet-1570	234	19	.	.	PUNCT
admet-1570	235	1	figure	figure	VERB
admet-1570	235	2	7	7	NUM
admet-1570	235	3	.	.	PUNCT
admet-1570	235	4	comparison	comparison	NOUN
admet-1570	235	5	of	of	ADP
admet-1570	235	6	pk	pk	NOUN
admet-1570	235	7	physiological	physiological	ADJ
admet-1570	235	8	protein	protein	NOUN
admet-1570	235	9	model	model	NOUN
admet-1570	235	10	lymph	lymph	NOUN
admet-1570	235	11	thoracic	thoracic	NOUN
admet-1570	235	12	duct	duct	NOUN
admet-1570	235	13	alt	alt	VERB
admet-1570	235	14	concentration	concentration	NOUN
admet-1570	235	15	following	follow	VERB
admet-1570	235	16	iv	iv	ADP
admet-1570	235	17	bolus	bolus	ADJ
admet-1570	235	18	injection	injection	NOUN
admet-1570	235	19	in	in	ADP
admet-1570	235	20	dog	dog	NOUN
admet-1570	235	21	(	(	PUNCT
admet-1570	235	22	line	line	NOUN
admet-1570	235	23	)	)	PUNCT
admet-1570	235	24	versus	versus	ADP
admet-1570	235	25	experimental	experimental	ADJ
admet-1570	235	26	data	datum	NOUN
admet-1570	235	27	(	(	PUNCT
admet-1570	235	28	solid	solid	ADJ
admet-1570	235	29	circles	circle	NOUN
admet-1570	235	30	)	)	PUNCT
admet-1570	235	31	of	of	ADP
admet-1570	235	32	fleisher	fleisher	NOUN
admet-1570	235	33	and	and	CCONJ
admet-1570	235	34	wakim	wakim	PROPN
admet-1570	235	35	.	.	PUNCT
admet-1570	236	1	the	the	DET
admet-1570	236	2	simultaneously	simultaneously	ADV
admet-1570	236	3	measured	measure	VERB
admet-1570	236	4	thoracic	thoracic	NOUN
admet-1570	236	5	duct	duct	NOUN
admet-1570	236	6	lymph	lymph	NOUN
admet-1570	236	7	alt	alt	VERB
admet-1570	236	8	concentration	concentration	NOUN
admet-1570	236	9	had	have	VERB
admet-1570	236	10	relatively	relatively	ADV
admet-1570	236	11	large	large	ADJ
admet-1570	236	12	variations	variation	NOUN
admet-1570	236	13	between	between	ADP
admet-1570	236	14	dogs	dog	NOUN
admet-1570	236	15	[	[	X
admet-1570	236	16	39	39	NUM
admet-1570	236	17	]	]	PUNCT
admet-1570	236	18	.	.	PUNCT
admet-1570	237	1	the	the	DET
admet-1570	237	2	model	model	NOUN
admet-1570	237	3	total	total	NOUN
admet-1570	237	4	lymph	lymph	NOUN
admet-1570	237	5	concentration	concentration	NOUN
admet-1570	237	6	is	be	AUX
admet-1570	237	7	given	give	VERB
admet-1570	237	8	in	in	ADP
admet-1570	237	9	terms	term	NOUN
admet-1570	237	10	of	of	ADP
admet-1570	237	11	the	the	DET
admet-1570	237	12	total	total	ADJ
admet-1570	237	13	lymph	lymph	NOUN
admet-1570	237	14	drainage	drainage	NOUN
admet-1570	237	15	of	of	ADP
admet-1570	237	16	the	the	DET
admet-1570	237	17	two	two	NUM
admet-1570	237	18	tissue	tissue	NOUN
admet-1570	237	19	compartments	compartment	NOUN
admet-1570	237	20	(	(	PUNCT
admet-1570	237	21	figure	figure	NOUN
admet-1570	237	22	1b	1b	NUM
admet-1570	237	23	):	):	PUNCT
admet-1570	237	24	1	1	NUM
admet-1570	237	25	1	1	NUM
admet-1570	237	26	2	2	NUM
admet-1570	237	27	2	2	NUM
admet-1570	237	28	1	1	NUM
admet-1570	237	29	2	2	NUM
admet-1570	237	30	lymph	lymph	NOUN
admet-1570	237	31	concentration	concentration	NOUN
admet-1570	237	32	=	=	SYM
admet-1570	237	33	l	l	NOUN
admet-1570	237	34	c	c	X
admet-1570	238	1	l	l	NOUN
admet-1570	238	2	c	c	NOUN
admet-1570	238	3	l	l	NOUN
admet-1570	238	4	l	l	NOUN
admet-1570	238	5	(	(	PUNCT
admet-1570	238	6	7	7	X
admet-1570	238	7	)	)	PUNCT
admet-1570	238	8	figure	figure	NOUN
admet-1570	238	9	7	7	NUM
admet-1570	238	10	shows	show	VERB
admet-1570	238	11	the	the	DET
admet-1570	238	12	relatively	relatively	ADV
admet-1570	238	13	good	good	ADJ
admet-1570	238	14	model	model	NOUN
admet-1570	238	15	fit	fit	PROPN
admet-1570	238	16	obtained	obtain	VERB
admet-1570	238	17	for	for	ADP
admet-1570	238	18	the	the	DET
admet-1570	238	19	lymph	lymph	NOUN
admet-1570	238	20	data	datum	NOUN
admet-1570	238	21	for	for	ADP
admet-1570	238	22	one	one	NUM
admet-1570	238	23	dog	dog	NOUN
admet-1570	238	24	.	.	PUNCT
admet-1570	239	1	these	these	DET
admet-1570	239	2	tissue	tissue	NOUN
admet-1570	239	3	volumes	volume	NOUN
admet-1570	239	4	and	and	CCONJ
admet-1570	239	5	lymph	lymph	NOUN
admet-1570	239	6	flows	flow	NOUN
admet-1570	239	7	should	should	AUX
admet-1570	239	8	be	be	AUX
admet-1570	239	9	regarded	regard	VERB
admet-1570	239	10	as	as	ADP
admet-1570	239	11	only	only	ADV
admet-1570	239	12	rough	rough	ADJ
admet-1570	239	13	approximations	approximation	NOUN
admet-1570	239	14	because	because	SCONJ
admet-1570	239	15	of	of	ADP
admet-1570	239	16	the	the	DET
admet-1570	239	17	large	large	ADJ
admet-1570	239	18	variation	variation	NOUN
admet-1570	239	19	between	between	ADP
admet-1570	239	20	dogs	dog	NOUN
admet-1570	239	21	and	and	CCONJ
admet-1570	239	22	the	the	DET
admet-1570	239	23	assumption	assumption	NOUN
admet-1570	239	24	that	that	SCONJ
admet-1570	239	25	there	there	PRON
admet-1570	239	26	are	be	VERB
admet-1570	239	27	only	only	ADV
admet-1570	239	28	two	two	NUM
admet-1570	239	29	tissue	tissue	NOUN
admet-1570	239	30	compartments	compartment	NOUN
admet-1570	239	31	.	.	PUNCT
admet-1570	240	1	however	however	ADV
admet-1570	240	2	,	,	PUNCT
admet-1570	240	3	the	the	DET
admet-1570	240	4	finding	finding	NOUN
admet-1570	240	5	that	that	SCONJ
admet-1570	240	6	the	the	DET
admet-1570	240	7	thoracic	thoracic	NOUN
admet-1570	240	8	duct	duct	NOUN
admet-1570	240	9	data	datum	NOUN
admet-1570	240	10	is	be	AUX
admet-1570	240	11	in	in	ADP
admet-1570	240	12	general	general	ADJ
admet-1570	240	13	agreement	agreement	NOUN
admet-1570	240	14	with	with	ADP
admet-1570	240	15	the	the	DET
admet-1570	240	16	model	model	NOUN
admet-1570	240	17	predictions	prediction	NOUN
admet-1570	240	18	with	with	ADP
admet-1570	240	19	reasonable	reasonable	ADJ
admet-1570	240	20	physiological	physiological	ADJ
admet-1570	240	21	parameters	parameter	NOUN
admet-1570	240	22	is	be	AUX
admet-1570	240	23	encouraging	encouraging	ADJ
admet-1570	240	24	and	and	CCONJ
admet-1570	240	25	provides	provide	VERB
admet-1570	240	26	additional	additional	ADJ
admet-1570	240	27	support	support	NOUN
admet-1570	240	28	for	for	ADP
admet-1570	240	29	the	the	DET
admet-1570	240	30	physiological	physiological	ADJ
admet-1570	240	31	model	model	NOUN
admet-1570	240	32	(	(	PUNCT
admet-1570	240	33	figure	figure	NOUN
admet-1570	240	34	1b	1b	NUM
admet-1570	240	35	)	)	PUNCT
admet-1570	240	36	,	,	PUNCT
admet-1570	240	37	with	with	SCONJ
admet-1570	240	38	the	the	DET
admet-1570	240	39	parameters	parameter	NOUN
admet-1570	240	40	summarized	summarize	VERB
admet-1570	240	41	in	in	ADP
admet-1570	240	42	table	table	NOUN
admet-1570	240	43	2	2	NUM
admet-1570	240	44	.	.	X
admet-1570	240	45	aspartate	aspartate	NOUN
admet-1570	240	46	aminotransferase	aminotransferase	PROPN
admet-1570	240	47	(	(	PUNCT
admet-1570	240	48	ast	ast	PROPN
admet-1570	240	49	)	)	PUNCT
admet-1570	240	50	and	and	CCONJ
admet-1570	240	51	creatine	creatine	PROPN
admet-1570	240	52	kinase	kinase	PROPN
admet-1570	240	53	(	(	PUNCT
admet-1570	240	54	ck	ck	NOUN
admet-1570	240	55	)	)	PUNCT
admet-1570	240	56	aspartate	aspartate	NOUN
admet-1570	240	57	aminotransferase	aminotransferase	NOUN
admet-1570	240	58	,	,	PUNCT
admet-1570	240	59	also	also	ADV
admet-1570	240	60	known	know	VERB
admet-1570	240	61	as	as	ADP
admet-1570	240	62	glutamic	glutamic	ADJ
admet-1570	240	63	-	-	PUNCT
admet-1570	240	64	oxalacetic	oxalacetic	ADJ
admet-1570	240	65	transaminase	transaminase	NOUN
admet-1570	240	66	,	,	PUNCT
admet-1570	240	67	is	be	AUX
admet-1570	240	68	a	a	DET
admet-1570	240	69	clinical	clinical	ADJ
admet-1570	240	70	marker	marker	NOUN
admet-1570	240	71	for	for	ADP
admet-1570	240	72	hepato	hepato	NOUN
admet-1570	240	73	-	-	PUNCT
admet-1570	240	74	cellular	cellular	ADJ
admet-1570	240	75	injury	injury	NOUN
admet-1570	240	76	secondary	secondary	ADJ
admet-1570	240	77	to	to	ADP
admet-1570	240	78	a	a	DET
admet-1570	240	79	variety	variety	NOUN
admet-1570	240	80	of	of	ADP
admet-1570	240	81	inflammatory	inflammatory	ADJ
admet-1570	240	82	conditions	condition	NOUN
admet-1570	240	83	.	.	PUNCT
admet-1570	241	1	there	there	PRON
admet-1570	241	2	are	be	VERB
admet-1570	241	3	two	two	NUM
admet-1570	241	4	forms	form	NOUN
admet-1570	241	5	of	of	ADP
admet-1570	241	6	the	the	DET
admet-1570	241	7	enzyme	enzyme	NOUN
admet-1570	241	8	found	find	VERB
admet-1570	241	9	in	in	ADP
admet-1570	241	10	plasma	plasma	NOUN
admet-1570	241	11	,	,	PUNCT
admet-1570	241	12	the	the	DET
admet-1570	241	13	“	"	PUNCT
admet-1570	241	14	cytoplasmic	cytoplasmic	ADJ
admet-1570	241	15	”	"	PUNCT
admet-1570	241	16	and	and	CCONJ
admet-1570	241	17	“	"	PUNCT
admet-1570	241	18	mitochondrial	mitochondrial	ADJ
admet-1570	241	19	”	"	PUNCT
admet-1570	241	20	,	,	PUNCT
admet-1570	241	21	with	with	ADP
admet-1570	241	22	similar	similar	ADJ
admet-1570	241	23	structures	structure	NOUN
admet-1570	241	24	but	but	CCONJ
admet-1570	241	25	markedly	markedly	ADV
admet-1570	241	26	different	different	ADJ
admet-1570	241	27	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	242	1	[	[	X
admet-1570	242	2	41,42	41,42	NOUN
admet-1570	242	3	]	]	PUNCT
admet-1570	242	4	.	.	PUNCT
admet-1570	243	1	fleisher	fleisher	PROPN
admet-1570	243	2	and	and	CCONJ
admet-1570	243	3	wakim	wakim	PROPN
admet-1570	244	1	[	[	X
admet-1570	244	2	41	41	NUM
admet-1570	244	3	]	]	PUNCT
admet-1570	244	4	investigated	investigate	VERB
admet-1570	244	5	the	the	DET
admet-1570	244	6	dog	dog	NOUN
admet-1570	244	7	pk	pk	NOUN
admet-1570	244	8	for	for	ADP
admet-1570	244	9	both	both	DET
admet-1570	244	10	forms	form	NOUN
admet-1570	244	11	of	of	ADP
admet-1570	244	12	purified	purified	ADJ
admet-1570	244	13	dog	dog	NOUN
admet-1570	244	14	admet	admet	PROPN
admet-1570	244	15	&	&	CCONJ
admet-1570	244	16	dmpk	dmpk	PROPN
admet-1570	244	17	11(1	11(1	NUM
admet-1570	244	18	)	)	PUNCT
admet-1570	244	19	(	(	PUNCT
admet-1570	244	20	2023	2023	NUM
admet-1570	244	21	)	)	PUNCT
admet-1570	244	22	57	57	NUM
admet-1570	244	23	-	-	SYM
admet-1570	244	24	80	80	NUM
admet-1570	244	25	protein	protein	NOUN
admet-1570	244	26	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	244	27	model	model	NOUN
admet-1570	244	28	doi	doi	NOUN
admet-1570	244	29	:	:	PUNCT
admet-1570	244	30	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	244	31	69	69	NUM
admet-1570	244	32	liver	liver	NOUN
admet-1570	244	33	alp	alp	NOUN
admet-1570	244	34	.	.	PUNCT
admet-1570	245	1	since	since	SCONJ
admet-1570	245	2	ast	ast	NOUN
admet-1570	245	3	has	have	VERB
admet-1570	245	4	a	a	DET
admet-1570	245	5	molecular	molecular	ADJ
admet-1570	245	6	weight	weight	NOUN
admet-1570	245	7	similar	similar	ADJ
admet-1570	245	8	to	to	AUX
admet-1570	245	9	alt	alt	VERB
admet-1570	245	10	,	,	PUNCT
admet-1570	245	11	it	it	PRON
admet-1570	245	12	should	should	AUX
admet-1570	245	13	have	have	VERB
admet-1570	245	14	the	the	DET
admet-1570	245	15	same	same	ADJ
admet-1570	245	16	f1	f1	NOUN
admet-1570	245	17	and	and	CCONJ
admet-1570	245	18	f2	f2	PROPN
admet-1570	245	19	and	and	CCONJ
admet-1570	245	20	lymph	lymph	NOUN
admet-1570	245	21	flows	flow	VERB
admet-1570	245	22	l1	l1	PROPN
admet-1570	245	23	and	and	CCONJ
admet-1570	245	24	l2	l2	NOUN
admet-1570	245	25	as	as	ADP
admet-1570	245	26	those	those	PRON
admet-1570	245	27	determined	determine	VERB
admet-1570	245	28	above	above	ADV
admet-1570	245	29	in	in	ADP
admet-1570	245	30	the	the	DET
admet-1570	245	31	dog	dog	NOUN
admet-1570	245	32	for	for	ADP
admet-1570	245	33	alt	alt	ADJ
admet-1570	245	34	.	.	PUNCT
admet-1570	246	1	thus	thus	ADV
admet-1570	246	2	,	,	PUNCT
admet-1570	246	3	there	there	PRON
admet-1570	246	4	is	be	VERB
admet-1570	246	5	only	only	ADV
admet-1570	246	6	one	one	NUM
admet-1570	246	7	adjustable	adjustable	ADJ
admet-1570	246	8	parameter	parameter	NOUN
admet-1570	246	9	:	:	PUNCT
admet-1570	246	10	clp	clp	PROPN
admet-1570	246	11	.	.	PUNCT
admet-1570	246	12	figure	figure	NOUN
admet-1570	246	13	8	8	NUM
admet-1570	246	14	and	and	CCONJ
admet-1570	246	15	table	table	NOUN
admet-1570	246	16	2	2	NUM
admet-1570	246	17	show	show	VERB
admet-1570	246	18	that	that	SCONJ
admet-1570	246	19	,	,	PUNCT
admet-1570	246	20	indeed	indeed	ADV
admet-1570	246	21	,	,	PUNCT
admet-1570	246	22	both	both	CCONJ
admet-1570	246	23	cytoplasmic	cytoplasmic	ADJ
admet-1570	246	24	and	and	CCONJ
admet-1570	246	25	mitochondrial	mitochondrial	ADJ
admet-1570	246	26	plasma	plasma	NOUN
admet-1570	246	27	ast	ast	NOUN
admet-1570	246	28	concentration	concentration	NOUN
admet-1570	246	29	following	follow	VERB
admet-1570	246	30	an	an	DET
admet-1570	246	31	iv	iv	NUM
admet-1570	246	32	bolus	bolus	NOUN
admet-1570	246	33	could	could	AUX
admet-1570	246	34	be	be	AUX
admet-1570	246	35	successfully	successfully	ADV
admet-1570	246	36	fit	fit	ADJ
admet-1570	246	37	by	by	ADP
admet-1570	246	38	the	the	DET
admet-1570	246	39	protein	protein	NOUN
admet-1570	246	40	model	model	NOUN
admet-1570	246	41	using	use	VERB
admet-1570	246	42	the	the	DET
admet-1570	246	43	previously	previously	ADV
admet-1570	246	44	determined	determine	VERB
admet-1570	246	45	dog	dog	NOUN
admet-1570	246	46	alt	alt	NOUN
admet-1570	246	47	f1	f1	NOUN
admet-1570	246	48	,	,	PUNCT
admet-1570	246	49	f2	f2	PROPN
admet-1570	246	50	,	,	PUNCT
admet-1570	246	51	l1	l1	PROPN
admet-1570	246	52	and	and	CCONJ
admet-1570	246	53	l2	l2	NOUN
admet-1570	246	54	.	.	PUNCT
admet-1570	247	1	the	the	DET
admet-1570	247	2	ability	ability	NOUN
admet-1570	247	3	to	to	PART
admet-1570	247	4	fit	fit	VERB
admet-1570	247	5	this	this	DET
admet-1570	247	6	novel	novel	ADJ
admet-1570	247	7	data	datum	NOUN
admet-1570	247	8	using	use	VERB
admet-1570	247	9	only	only	ADV
admet-1570	247	10	one	one	NUM
admet-1570	247	11	adjustable	adjustable	ADJ
admet-1570	247	12	parameter	parameter	NOUN
admet-1570	247	13	dramatically	dramatically	ADV
admet-1570	247	14	illustrates	illustrate	VERB
admet-1570	247	15	the	the	DET
admet-1570	247	16	advantage	advantage	NOUN
admet-1570	247	17	of	of	ADP
admet-1570	247	18	using	use	VERB
admet-1570	247	19	this	this	DET
admet-1570	247	20	physiological	physiological	ADJ
admet-1570	247	21	model	model	NOUN
admet-1570	247	22	.	.	PUNCT
admet-1570	248	1	mitochondrial	mitochondrial	ADJ
admet-1570	248	2	ast	ast	NOUN
admet-1570	248	3	is	be	AUX
admet-1570	248	4	metabolized	metabolize	VERB
admet-1570	248	5	by	by	ADP
admet-1570	248	6	the	the	DET
admet-1570	248	7	liver	liver	NOUN
admet-1570	248	8	kupffer	kupffer	NOUN
admet-1570	248	9	cells	cell	NOUN
admet-1570	248	10	and	and	CCONJ
admet-1570	248	11	,	,	PUNCT
admet-1570	248	12	as	as	SCONJ
admet-1570	248	13	is	be	AUX
admet-1570	248	14	characteristic	characteristic	ADJ
admet-1570	248	15	of	of	ADP
admet-1570	248	16	this	this	DET
admet-1570	248	17	mechanism	mechanism	NOUN
admet-1570	248	18	,	,	PUNCT
admet-1570	248	19	has	have	VERB
admet-1570	248	20	a	a	DET
admet-1570	248	21	very	very	ADV
admet-1570	248	22	high	high	ADJ
admet-1570	248	23	metabolic	metabolic	NOUN
admet-1570	248	24	rate	rate	NOUN
admet-1570	248	25	,	,	PUNCT
admet-1570	248	26	with	with	ADP
admet-1570	248	27	a	a	DET
admet-1570	248	28	tm	tm	NOUN
admet-1570	248	29	of	of	ADP
admet-1570	248	30	only	only	ADV
admet-1570	248	31	50	50	NUM
admet-1570	248	32	minutes	minute	NOUN
admet-1570	248	33	.	.	PUNCT
admet-1570	249	1	cytoplasmic	cytoplasmic	ADJ
admet-1570	249	2	ast	ast	NOUN
admet-1570	249	3	is	be	AUX
admet-1570	249	4	metabolized	metabolize	VERB
admet-1570	249	5	primarily	primarily	ADV
admet-1570	249	6	by	by	ADP
admet-1570	249	7	the	the	DET
admet-1570	249	8	liver	liver	NOUN
admet-1570	249	9	sinusoidal	sinusoidal	NOUN
admet-1570	249	10	cells	cell	NOUN
admet-1570	249	11	and	and	CCONJ
admet-1570	249	12	has	have	VERB
admet-1570	249	13	a	a	DET
admet-1570	249	14	tm	tm	NOUN
admet-1570	249	15	of	of	ADP
admet-1570	249	16	670	670	NUM
admet-1570	249	17	minutes	minute	NOUN
admet-1570	249	18	,	,	PUNCT
admet-1570	249	19	13	13	NUM
admet-1570	249	20	-	-	NOUN
admet-1570	249	21	fold	fold	VERB
admet-1570	249	22	slower	slow	ADV
admet-1570	249	23	than	than	ADP
admet-1570	249	24	mitochondrial	mitochondrial	ADJ
admet-1570	249	25	ast	ast	NOUN
admet-1570	249	26	.	.	PUNCT
admet-1570	250	1	figure	figure	NOUN
admet-1570	250	2	8	8	NUM
admet-1570	250	3	.	.	PUNCT
admet-1570	251	1	comparison	comparison	NOUN
admet-1570	251	2	of	of	ADP
admet-1570	251	3	pk	pk	NOUN
admet-1570	251	4	physiological	physiological	ADJ
admet-1570	251	5	protein	protein	NOUN
admet-1570	251	6	model	model	NOUN
admet-1570	251	7	prediction	prediction	NOUN
admet-1570	251	8	(	(	PUNCT
admet-1570	251	9	line	line	NOUN
admet-1570	251	10	)	)	PUNCT
admet-1570	251	11	following	follow	VERB
admet-1570	251	12	iv	iv	NUM
admet-1570	251	13	bolus	bolus	X
admet-1570	251	14	dose	dose	NOUN
admet-1570	251	15	of	of	ADP
admet-1570	251	16	mitochondrial	mitochondrial	ADJ
admet-1570	251	17	(	(	PUNCT
admet-1570	251	18	left	leave	VERB
admet-1570	251	19	panel	panel	NOUN
admet-1570	251	20	)	)	PUNCT
admet-1570	251	21	or	or	CCONJ
admet-1570	251	22	cytoplasmic	cytoplasmic	ADJ
admet-1570	251	23	(	(	PUNCT
admet-1570	251	24	middle	middle	ADJ
admet-1570	251	25	panel	panel	NOUN
admet-1570	251	26	)	)	PUNCT
admet-1570	251	27	ast	ast	NOUN
admet-1570	252	1	and	and	CCONJ
admet-1570	252	2	creatine	creatine	PROPN
admet-1570	252	3	kinase	kinase	PROPN
admet-1570	252	4	(	(	PUNCT
admet-1570	252	5	right	right	ADJ
admet-1570	252	6	panel	panel	NOUN
admet-1570	252	7	)	)	PUNCT
admet-1570	252	8	versus	versus	ADP
admet-1570	252	9	experimental	experimental	ADJ
admet-1570	252	10	data	datum	NOUN
admet-1570	252	11	(	(	PUNCT
admet-1570	252	12	solid	solid	ADJ
admet-1570	252	13	circles	circle	NOUN
admet-1570	252	14	)	)	PUNCT
admet-1570	252	15	in	in	ADP
admet-1570	252	16	dog	dog	NOUN
admet-1570	252	17	.	.	PUNCT
admet-1570	253	1	creatine	creatine	PROPN
admet-1570	253	2	kinase	kinase	PROPN
admet-1570	253	3	(	(	PUNCT
admet-1570	253	4	ck	ck	PROPN
admet-1570	253	5	)	)	PUNCT
admet-1570	253	6	is	be	AUX
admet-1570	253	7	another	another	DET
admet-1570	253	8	kupffer	kupffer	NOUN
admet-1570	253	9	-	-	PUNCT
admet-1570	253	10	metabolized	metabolize	VERB
admet-1570	253	11	protein	protein	NOUN
admet-1570	253	12	[	[	X
admet-1570	253	13	38	38	NUM
admet-1570	253	14	]	]	PUNCT
admet-1570	253	15	.	.	PUNCT
admet-1570	254	1	aktas	akta	NOUN
admet-1570	254	2	et	et	PROPN
admet-1570	254	3	al	al	PROPN
admet-1570	254	4	.	.	PUNCT
admet-1570	255	1	[	[	X
admet-1570	255	2	43	43	NUM
admet-1570	255	3	]	]	PUNCT
admet-1570	255	4	have	have	AUX
admet-1570	255	5	determined	determine	VERB
admet-1570	255	6	the	the	DET
admet-1570	255	7	plasma	plasma	NOUN
admet-1570	255	8	kinetics	kinetic	NOUN
admet-1570	255	9	in	in	ADP
admet-1570	255	10	the	the	DET
admet-1570	255	11	dog	dog	NOUN
admet-1570	255	12	following	follow	VERB
admet-1570	255	13	iv	iv	NUM
admet-1570	255	14	injections	injection	NOUN
admet-1570	255	15	of	of	ADP
admet-1570	255	16	ck	ck	NOUN
admet-1570	255	17	purified	purify	VERB
admet-1570	255	18	from	from	ADP
admet-1570	255	19	dog	dog	NOUN
admet-1570	255	20	muscle	muscle	NOUN
admet-1570	255	21	homogenates	homogenate	NOUN
admet-1570	255	22	.	.	PUNCT
admet-1570	256	1	ck	ck	INTJ
admet-1570	256	2	should	should	AUX
admet-1570	256	3	have	have	VERB
admet-1570	256	4	the	the	DET
admet-1570	256	5	same	same	ADJ
admet-1570	256	6	dog	dog	NOUN
admet-1570	256	7	l1	l1	PROPN
admet-1570	256	8	and	and	CCONJ
admet-1570	256	9	l2	l2	NOUN
admet-1570	256	10	as	as	ADP
admet-1570	256	11	alt	alt	ADJ
admet-1570	256	12	,	,	PUNCT
admet-1570	256	13	but	but	CCONJ
admet-1570	256	14	since	since	SCONJ
admet-1570	256	15	it	it	PRON
admet-1570	256	16	has	have	VERB
admet-1570	256	17	about	about	ADV
admet-1570	256	18	twice	twice	DET
admet-1570	256	19	the	the	DET
admet-1570	256	20	molecular	molecular	ADJ
admet-1570	256	21	weight	weight	NOUN
admet-1570	256	22	of	of	ADP
admet-1570	256	23	alt	alt	ADJ
admet-1570	256	24	,	,	PUNCT
admet-1570	256	25	it	it	PRON
admet-1570	256	26	is	be	AUX
admet-1570	256	27	expected	expect	VERB
admet-1570	256	28	to	to	PART
admet-1570	256	29	have	have	VERB
admet-1570	256	30	smaller	small	ADJ
admet-1570	256	31	filtration	filtration	NOUN
admet-1570	256	32	constants	constant	NOUN
admet-1570	256	33	and	and	CCONJ
admet-1570	256	34	,	,	PUNCT
admet-1570	256	35	therefore	therefore	ADV
admet-1570	256	36	,	,	PUNCT
admet-1570	256	37	there	there	PRON
admet-1570	256	38	are	be	VERB
admet-1570	256	39	two	two	NUM
admet-1570	256	40	adjustable	adjustable	ADJ
admet-1570	256	41	parameters	parameter	NOUN
admet-1570	256	42	:	:	PUNCT
admet-1570	256	43	clp	clp	PROPN
admet-1570	256	44	and	and	CCONJ
admet-1570	256	45	f.	f.	PROPN
admet-1570	256	46	consistent	consistent	ADJ
admet-1570	256	47	with	with	ADP
admet-1570	256	48	this	this	PRON
admet-1570	256	49	,	,	PUNCT
admet-1570	256	50	the	the	DET
admet-1570	256	51	plasma	plasma	NOUN
admet-1570	256	52	pk	pk	NOUN
admet-1570	256	53	data	datum	NOUN
admet-1570	256	54	are	be	AUX
admet-1570	256	55	well	well	ADV
admet-1570	256	56	fit	fit	ADJ
admet-1570	256	57	by	by	ADP
admet-1570	256	58	the	the	DET
admet-1570	256	59	model	model	NOUN
admet-1570	256	60	(	(	PUNCT
admet-1570	256	61	figure	figure	NOUN
admet-1570	256	62	8	8	NUM
admet-1570	256	63	,	,	PUNCT
admet-1570	256	64	right	right	ADJ
admet-1570	256	65	panel	panel	NOUN
admet-1570	256	66	)	)	PUNCT
admet-1570	256	67	with	with	ADP
admet-1570	256	68	f1	f1	NOUN
admet-1570	256	69	=	=	SYM
admet-1570	256	70	f2	f2	PROPN
admet-1570	256	71	=	=	NOUN
admet-1570	256	72	0.37	0.37	NUM
admet-1570	256	73	,	,	PUNCT
admet-1570	256	74	30	30	NUM
admet-1570	256	75	%	%	NOUN
admet-1570	256	76	smaller	small	ADJ
admet-1570	256	77	than	than	ADP
admet-1570	256	78	alt	alt	VERB
admet-1570	256	79	and	and	CCONJ
admet-1570	256	80	ast	ast	VERB
admet-1570	256	81	,	,	PUNCT
admet-1570	256	82	and	and	CCONJ
admet-1570	256	83	the	the	DET
admet-1570	256	84	same	same	ADJ
admet-1570	256	85	dog	dog	NOUN
admet-1570	256	86	l1	l1	PROPN
admet-1570	256	87	and	and	CCONJ
admet-1570	256	88	l2	l2	NOUN
admet-1570	256	89	as	as	ADP
admet-1570	256	90	alt	alt	NOUN
admet-1570	256	91	and	and	CCONJ
admet-1570	256	92	ast	ast	NOUN
admet-1570	256	93	(	(	PUNCT
admet-1570	256	94	table	table	NOUN
admet-1570	256	95	2	2	NUM
admet-1570	256	96	)	)	PUNCT
admet-1570	256	97	.	.	PUNCT
admet-1570	257	1	as	as	SCONJ
admet-1570	257	2	expected	expect	VERB
admet-1570	257	3	for	for	ADP
admet-1570	257	4	liver	liver	NOUN
admet-1570	257	5	kupffer	kupffer	NOUN
admet-1570	257	6	metabolism	metabolism	NOUN
admet-1570	257	7	,	,	PUNCT
admet-1570	257	8	it	it	PRON
admet-1570	257	9	has	have	VERB
admet-1570	257	10	a	a	DET
admet-1570	257	11	relatively	relatively	ADV
admet-1570	257	12	short	short	ADJ
admet-1570	257	13	metabolic	metabolic	NOUN
admet-1570	257	14	time	time	NOUN
admet-1570	257	15	constant	constant	ADJ
admet-1570	257	16	(	(	PUNCT
admet-1570	257	17	tm	tm	NOUN
admet-1570	257	18	)	)	PUNCT
admet-1570	257	19	of	of	ADP
admet-1570	257	20	88	88	NUM
admet-1570	257	21	min	min	NOUN
admet-1570	257	22	(	(	PUNCT
admet-1570	257	23	table	table	NOUN
admet-1570	257	24	1	1	NUM
admet-1570	257	25	)	)	PUNCT
admet-1570	257	26	.	.	PUNCT
admet-1570	258	1	lactate	lactate	NOUN
admet-1570	258	2	dehydrogenase	dehydrogenase	NOUN
admet-1570	258	3	(	(	PUNCT
admet-1570	258	4	ld	ld	NOUN
admet-1570	258	5	)	)	PUNCT
admet-1570	258	6	lactate	lactate	NOUN
admet-1570	258	7	dehydrogenase	dehydrogenase	NOUN
admet-1570	258	8	is	be	AUX
admet-1570	258	9	a	a	DET
admet-1570	258	10	tetramer	tetramer	NOUN
admet-1570	258	11	constructed	construct	VERB
admet-1570	258	12	from	from	ADP
admet-1570	258	13	different	different	ADJ
admet-1570	258	14	numbers	number	NOUN
admet-1570	258	15	of	of	ADP
admet-1570	258	16	the	the	DET
admet-1570	258	17	two	two	NUM
admet-1570	258	18	monomers	monomer	NOUN
admet-1570	258	19	called	call	VERB
admet-1570	258	20	h	h	NOUN
admet-1570	258	21	(	(	PUNCT
admet-1570	258	22	heart	heart	NOUN
admet-1570	258	23	)	)	PUNCT
admet-1570	258	24	and	and	CCONJ
admet-1570	258	25	m	m	PROPN
admet-1570	258	26	(	(	PUNCT
admet-1570	258	27	muscle	muscle	NOUN
admet-1570	258	28	)	)	PUNCT
admet-1570	258	29	,	,	PUNCT
admet-1570	258	30	resulting	result	VERB
admet-1570	258	31	in	in	ADP
admet-1570	258	32	5	5	NUM
admet-1570	258	33	different	different	ADJ
admet-1570	258	34	isoenzymes	isoenzyme	NOUN
admet-1570	258	35	:	:	PUNCT
admet-1570	258	36	ld1	ld1	NOUN
admet-1570	258	37	(	(	PUNCT
admet-1570	258	38	h4	h4	PROPN
admet-1570	258	39	)	)	PUNCT
admet-1570	258	40	,	,	PUNCT
admet-1570	258	41	ld2	ld2	PROPN
admet-1570	258	42	(	(	PUNCT
admet-1570	258	43	h3	h3	VERB
admet-1570	258	44	m	m	PROPN
admet-1570	258	45	)	)	PUNCT
admet-1570	258	46	,	,	PUNCT
admet-1570	258	47	ld3	ld3	NOUN
admet-1570	258	48	(	(	PUNCT
admet-1570	258	49	h2m2	h2m2	NOUN
admet-1570	258	50	)	)	PUNCT
admet-1570	258	51	,	,	PUNCT
admet-1570	258	52	ld4	ld4	NOUN
admet-1570	258	53	(	(	PUNCT
admet-1570	258	54	hm3	hm3	PROPN
admet-1570	258	55	)	)	PUNCT
admet-1570	258	56	and	and	CCONJ
admet-1570	258	57	ld5	ld5	NOUN
admet-1570	258	58	(	(	PUNCT
admet-1570	258	59	m4	m4	PROPN
admet-1570	258	60	)	)	PUNCT
admet-1570	259	1	[	[	X
admet-1570	259	2	44	44	NUM
admet-1570	259	3	]	]	PUNCT
admet-1570	259	4	.	.	PUNCT
admet-1570	260	1	the	the	DET
admet-1570	260	2	predominant	predominant	ADJ
admet-1570	260	3	diagnostic	diagnostic	ADJ
admet-1570	260	4	isoenzymes	isoenzyme	NOUN
admet-1570	260	5	are	be	AUX
admet-1570	260	6	ld1	ld1	ADJ
admet-1570	260	7	which	which	PRON
admet-1570	260	8	increases	increase	VERB
admet-1570	260	9	in	in	ADP
admet-1570	260	10	acute	acute	ADJ
admet-1570	260	11	myocardial	myocardial	ADJ
admet-1570	260	12	infarction	infarction	NOUN
admet-1570	260	13	and	and	CCONJ
admet-1570	260	14	ld5	ld5	NOUN
admet-1570	260	15	,	,	PUNCT
admet-1570	260	16	which	which	PRON
admet-1570	260	17	is	be	AUX
admet-1570	260	18	increased	increase	VERB
admet-1570	260	19	in	in	ADP
admet-1570	260	20	skeletal	skeletal	ADJ
admet-1570	260	21	muscle	muscle	NOUN
admet-1570	260	22	(	(	PUNCT
admet-1570	260	23	e.g.	e.g.	ADV
admet-1570	260	24	,	,	PUNCT
admet-1570	260	25	muscular	muscular	ADJ
admet-1570	260	26	dystrophy	dystrophy	NOUN
admet-1570	260	27	)	)	PUNCT
admet-1570	260	28	and	and	CCONJ
admet-1570	260	29	liver	liver	NOUN
admet-1570	260	30	pathologies	pathology	NOUN
admet-1570	260	31	[	[	X
admet-1570	260	32	44	44	NUM
admet-1570	260	33	]	]	PUNCT
admet-1570	260	34	.	.	PUNCT
admet-1570	261	1	ld5	ld5	NOUN
admet-1570	261	2	is	be	AUX
admet-1570	261	3	metabolized	metabolize	VERB
admet-1570	261	4	predominantly	predominantly	ADV
admet-1570	261	5	by	by	ADP
admet-1570	261	6	liver	liver	NOUN
admet-1570	261	7	kupffer	kupffer	NOUN
admet-1570	261	8	cells	cell	NOUN
admet-1570	261	9	and	and	CCONJ
admet-1570	261	10	,	,	PUNCT
admet-1570	261	11	accordingly	accordingly	ADV
admet-1570	261	12	,	,	PUNCT
admet-1570	261	13	should	should	AUX
admet-1570	261	14	have	have	VERB
admet-1570	261	15	a	a	DET
admet-1570	261	16	relatively	relatively	ADV
admet-1570	261	17	short	short	ADJ
admet-1570	261	18	metabolic	metabolic	NOUN
admet-1570	261	19	time	time	NOUN
admet-1570	261	20	constant	constant	ADJ
admet-1570	261	21	.	.	PUNCT
admet-1570	262	1	in	in	ADP
admet-1570	262	2	contrast	contrast	NOUN
admet-1570	262	3	,	,	PUNCT
admet-1570	262	4	ld1	ld1	NOUN
admet-1570	262	5	is	be	AUX
admet-1570	262	6	not	not	PART
admet-1570	262	7	metabolized	metabolize	VERB
admet-1570	262	8	by	by	ADP
admet-1570	262	9	kupffer	kupffer	NOUN
admet-1570	262	10	cells	cell	NOUN
admet-1570	262	11	and	and	CCONJ
admet-1570	262	12	should	should	AUX
admet-1570	262	13	have	have	VERB
admet-1570	262	14	a	a	DET
admet-1570	262	15	corresponding	correspond	VERB
admet-1570	262	16	slower	slow	ADJ
admet-1570	262	17	metabolic	metabolic	NOUN
admet-1570	262	18	rate	rate	NOUN
admet-1570	263	1	[	[	X
admet-1570	263	2	38	38	NUM
admet-1570	263	3	]	]	PUNCT
admet-1570	263	4	.	.	PUNCT
admet-1570	264	1	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	265	1	d.g	d.g	PROPN
admet-1570	265	2	.	.	PROPN
admet-1570	265	3	levitt	levitt	PROPN
admet-1570	265	4	and	and	CCONJ
admet-1570	265	5	m.d	m.d	PROPN
admet-1570	265	6	.	.	PROPN
admet-1570	265	7	levitt	levitt	PROPN
admet-1570	265	8	admet	admet	PROPN
admet-1570	265	9	&	&	CCONJ
admet-1570	265	10	dmpk	dmpk	PROPN
admet-1570	265	11	11(1	11(1	NUM
admet-1570	265	12	)	)	PUNCT
admet-1570	265	13	(	(	PUNCT
admet-1570	265	14	2023	2023	NUM
admet-1570	265	15	)	)	PUNCT
admet-1570	265	16	57	57	NUM
admet-1570	265	17	-	-	SYM
admet-1570	265	18	80	80	NUM
admet-1570	265	19	70	70	NUM
admet-1570	265	20	figure	figure	NOUN
admet-1570	265	21	9	9	NUM
admet-1570	265	22	.	.	PUNCT
admet-1570	265	23	comparison	comparison	NOUN
admet-1570	265	24	of	of	ADP
admet-1570	265	25	pk	pk	NOUN
admet-1570	265	26	physiological	physiological	ADJ
admet-1570	265	27	protein	protein	NOUN
admet-1570	265	28	model	model	NOUN
admet-1570	265	29	prediction	prediction	NOUN
admet-1570	265	30	(	(	PUNCT
admet-1570	265	31	line	line	NOUN
admet-1570	265	32	)	)	PUNCT
admet-1570	265	33	following	follow	VERB
admet-1570	265	34	iv	iv	NUM
admet-1570	265	35	bolus	bolus	ADJ
admet-1570	265	36	injections	injection	NOUN
admet-1570	265	37	in	in	ADP
admet-1570	265	38	the	the	DET
admet-1570	265	39	lamb	lamb	NOUN
admet-1570	265	40	of	of	ADP
admet-1570	265	41	the	the	DET
admet-1570	265	42	sheep	sheep	NOUN
admet-1570	265	43	purified	purify	VERB
admet-1570	265	44	protein	protein	NOUN
admet-1570	265	45	lactate	lactate	NOUN
admet-1570	265	46	dehydrogenase	dehydrogenase	NOUN
admet-1570	265	47	isoenzymes	isoenzyme	NOUN
admet-1570	265	48	ld1	ld1	NOUN
admet-1570	265	49	(	(	PUNCT
admet-1570	265	50	heart	heart	NOUN
admet-1570	265	51	)	)	PUNCT
admet-1570	265	52	(	(	PUNCT
admet-1570	265	53	left	leave	VERB
admet-1570	265	54	)	)	PUNCT
admet-1570	265	55	and	and	CCONJ
admet-1570	265	56	ld5	ld5	NOUN
admet-1570	265	57	(	(	PUNCT
admet-1570	265	58	skeletal	skeletal	ADJ
admet-1570	265	59	muscle	muscle	NOUN
admet-1570	265	60	)	)	PUNCT
admet-1570	265	61	(	(	PUNCT
admet-1570	265	62	right	right	NOUN
admet-1570	265	63	)	)	PUNCT
admet-1570	265	64	versus	versus	ADP
admet-1570	265	65	experimental	experimental	ADJ
admet-1570	265	66	data	datum	NOUN
admet-1570	265	67	(	(	PUNCT
admet-1570	265	68	solid	solid	ADJ
admet-1570	265	69	circles	circle	NOUN
admet-1570	265	70	)	)	PUNCT
admet-1570	265	71	.	.	PUNCT
admet-1570	266	1	boyd	boyd	PROPN
admet-1570	266	2	has	have	AUX
admet-1570	266	3	reported	report	VERB
admet-1570	266	4	the	the	DET
admet-1570	266	5	plasma	plasma	NOUN
admet-1570	266	6	kinetics	kinetic	NOUN
admet-1570	266	7	in	in	ADP
admet-1570	266	8	lambs	lamb	NOUN
admet-1570	266	9	following	follow	VERB
admet-1570	266	10	iv	iv	ADP
admet-1570	266	11	bolus	bolus	ADJ
admet-1570	266	12	injections	injection	NOUN
admet-1570	266	13	of	of	ADP
admet-1570	266	14	ld1	ld1	NOUN
admet-1570	266	15	(	(	PUNCT
admet-1570	266	16	purified	purify	VERB
admet-1570	266	17	from	from	ADP
admet-1570	266	18	sheep	sheep	NOUN
admet-1570	266	19	heart	heart	NOUN
admet-1570	266	20	)	)	PUNCT
admet-1570	266	21	and	and	CCONJ
admet-1570	266	22	ld5	ld5	NOUN
admet-1570	266	23	(	(	PUNCT
admet-1570	266	24	purified	purify	VERB
admet-1570	266	25	from	from	ADP
admet-1570	266	26	sheep	sheep	NOUN
admet-1570	266	27	skeletal	skeletal	ADJ
admet-1570	266	28	muscle	muscle	NOUN
admet-1570	266	29	)	)	PUNCT
admet-1570	266	30	.	.	PUNCT
admet-1570	267	1	we	we	PRON
admet-1570	267	2	assume	assume	VERB
admet-1570	267	3	the	the	DET
admet-1570	267	4	tissue	tissue	NOUN
admet-1570	267	5	space	space	NOUN
admet-1570	267	6	volumes	volume	NOUN
admet-1570	267	7	are	be	AUX
admet-1570	267	8	identical	identical	ADJ
admet-1570	267	9	to	to	ADP
admet-1570	267	10	those	those	PRON
admet-1570	267	11	determined	determine	VERB
admet-1570	267	12	for	for	ADP
admet-1570	267	13	the	the	DET
admet-1570	267	14	dog	dog	NOUN
admet-1570	267	15	(	(	PUNCT
admet-1570	267	16	v1	v1	NOUN
admet-1570	267	17	/	/	SYM
admet-1570	267	18	vp	vp	NOUN
admet-1570	267	19	=	=	SYM
admet-1570	267	20	1.0	1.0	NUM
admet-1570	267	21	and	and	CCONJ
admet-1570	267	22	v2	v2	PROPN
admet-1570	267	23	/	/	SYM
admet-1570	267	24	vp	vp	NOUN
admet-1570	267	25	=	=	NOUN
admet-1570	267	26	0.3	0.3	NUM
admet-1570	267	27	)	)	PUNCT
admet-1570	267	28	.	.	PUNCT
admet-1570	268	1	as	as	SCONJ
admet-1570	268	2	shown	show	VERB
admet-1570	268	3	in	in	ADP
admet-1570	268	4	figure	figure	NOUN
admet-1570	268	5	9	9	NUM
admet-1570	268	6	,	,	PUNCT
admet-1570	268	7	both	both	DET
admet-1570	268	8	forms	form	NOUN
admet-1570	268	9	were	be	AUX
admet-1570	268	10	adequately	adequately	ADV
admet-1570	268	11	fit	fit	ADJ
admet-1570	268	12	using	use	VERB
admet-1570	268	13	this	this	DET
admet-1570	268	14	convection	convection	NOUN
admet-1570	268	15	model	model	NOUN
admet-1570	268	16	with	with	ADP
admet-1570	268	17	the	the	DET
admet-1570	268	18	corresponding	corresponding	ADJ
admet-1570	268	19	f1	f1	NOUN
admet-1570	268	20	=	=	SYM
admet-1570	268	21	f2	f2	PROPN
admet-1570	268	22	=	=	NOUN
admet-1570	268	23	0.53	0.53	NUM
admet-1570	268	24	,	,	PUNCT
admet-1570	268	25	and	and	CCONJ
admet-1570	268	26	lymph	lymph	NOUN
admet-1570	268	27	flows	flow	VERB
admet-1570	268	28	l1=3.85	l1=3.85	NOUN
admet-1570	268	29	and	and	CCONJ
admet-1570	268	30	l2	l2	NOUN
admet-1570	268	31	=	=	SYM
admet-1570	268	32	1.35	1.35	NUM
admet-1570	268	33	(	(	PUNCT
admet-1570	268	34	table	table	NOUN
admet-1570	268	35	2	2	NUM
admet-1570	268	36	)	)	PUNCT
admet-1570	268	37	.	.	PUNCT
admet-1570	269	1	these	these	DET
admet-1570	269	2	results	result	NOUN
admet-1570	269	3	are	be	AUX
admet-1570	269	4	more	more	ADV
admet-1570	269	5	uncertain	uncertain	ADJ
admet-1570	269	6	than	than	ADP
admet-1570	269	7	the	the	DET
admet-1570	269	8	dog	dog	NOUN
admet-1570	269	9	or	or	CCONJ
admet-1570	269	10	human	human	NOUN
admet-1570	269	11	because	because	SCONJ
admet-1570	269	12	there	there	PRON
admet-1570	269	13	are	be	VERB
admet-1570	269	14	no	no	DET
admet-1570	269	15	lamb	lamb	NOUN
admet-1570	269	16	lymph	lymph	NOUN
admet-1570	269	17	protein	protein	NOUN
admet-1570	269	18	data	datum	NOUN
admet-1570	269	19	to	to	PART
admet-1570	269	20	constrain	constrain	VERB
admet-1570	269	21	them	they	PRON
admet-1570	269	22	.	.	PUNCT
admet-1570	270	1	these	these	DET
admet-1570	270	2	lymph	lymph	NOUN
admet-1570	270	3	flows	flow	VERB
admet-1570	270	4	(	(	PUNCT
admet-1570	270	5	total	total	ADJ
admet-1570	270	6	flow	flow	NOUN
admet-1570	270	7	=	=	NOUN
admet-1570	270	8	5.2	5.2	NUM
admet-1570	270	9	ml	ml	NOUN
admet-1570	270	10	/	/	SYM
admet-1570	270	11	min/70	min/70	PROPN
admet-1570	270	12	kg	kg	PROPN
admet-1570	270	13	)	)	PUNCT
admet-1570	270	14	,	,	PUNCT
admet-1570	270	15	which	which	PRON
admet-1570	270	16	are	be	AUX
admet-1570	270	17	significantly	significantly	ADV
admet-1570	270	18	larger	large	ADJ
admet-1570	270	19	than	than	ADP
admet-1570	270	20	those	those	PRON
admet-1570	270	21	of	of	ADP
admet-1570	270	22	dog	dog	NOUN
admet-1570	270	23	or	or	CCONJ
admet-1570	270	24	human	human	NOUN
admet-1570	270	25	are	be	AUX
admet-1570	270	26	consistent	consistent	ADJ
admet-1570	270	27	with	with	ADP
admet-1570	270	28	the	the	DET
admet-1570	270	29	high	high	ADJ
admet-1570	270	30	values	value	NOUN
admet-1570	270	31	reported	report	VERB
admet-1570	270	32	for	for	ADP
admet-1570	270	33	lamb	lamb	PROPN
admet-1570	270	34	thoracic	thoracic	NOUN
admet-1570	270	35	duct	duct	NOUN
admet-1570	270	36	[	[	X
admet-1570	270	37	45	45	NUM
admet-1570	270	38	]	]	PUNCT
admet-1570	270	39	.	.	PUNCT
admet-1570	271	1	as	as	SCONJ
admet-1570	271	2	expected	expect	VERB
admet-1570	271	3	for	for	ADP
admet-1570	271	4	these	these	DET
admet-1570	271	5	two	two	NUM
admet-1570	271	6	molecules	molecule	NOUN
admet-1570	271	7	with	with	ADP
admet-1570	271	8	similar	similar	ADJ
admet-1570	271	9	structures	structure	NOUN
admet-1570	271	10	,	,	PUNCT
admet-1570	271	11	they	they	PRON
admet-1570	271	12	were	be	AUX
admet-1570	271	13	fit	fit	ADJ
admet-1570	271	14	with	with	ADP
admet-1570	271	15	identical	identical	ADJ
admet-1570	271	16	values	value	NOUN
admet-1570	271	17	of	of	ADP
admet-1570	271	18	f1	f1	NOUN
admet-1570	271	19	,	,	PUNCT
admet-1570	271	20	f2	f2	PROPN
admet-1570	271	21	,	,	PUNCT
admet-1570	271	22	l1	l1	PROPN
admet-1570	271	23	and	and	CCONJ
admet-1570	271	24	l2	l2	NOUN
admet-1570	271	25	.	.	PUNCT
admet-1570	272	1	the	the	DET
admet-1570	272	2	tm	tm	PROPN
admet-1570	272	3	for	for	ADP
admet-1570	272	4	ld5	ld5	PROPN
admet-1570	272	5	(	(	PUNCT
admet-1570	272	6	kupffer	kupffer	NOUN
admet-1570	272	7	cell	cell	NOUN
admet-1570	272	8	metabolism	metabolism	NOUN
admet-1570	272	9	)	)	PUNCT
admet-1570	272	10	is	be	AUX
admet-1570	272	11	465	465	NUM
admet-1570	272	12	minutes	minute	NOUN
admet-1570	272	13	,	,	PUNCT
admet-1570	272	14	more	more	ADJ
admet-1570	272	15	than	than	ADP
admet-1570	272	16	7	7	NUM
admet-1570	272	17	times	time	NOUN
admet-1570	272	18	shorter	short	ADJ
admet-1570	272	19	than	than	ADP
admet-1570	272	20	the	the	DET
admet-1570	272	21	ld1	ld1	ADJ
admet-1570	272	22	tm	tm	NOUN
admet-1570	272	23	of	of	ADP
admet-1570	272	24	3418	3418	NUM
admet-1570	272	25	minutes	minute	NOUN
admet-1570	272	26	(	(	PUNCT
admet-1570	272	27	table	table	NOUN
admet-1570	272	28	1	1	NUM
admet-1570	272	29	)	)	PUNCT
admet-1570	272	30	.	.	PUNCT
admet-1570	273	1	alkaline	alkaline	ADJ
admet-1570	273	2	phosphatase	phosphatase	NOUN
admet-1570	273	3	(	(	PUNCT
admet-1570	273	4	alp	alp	PROPN
admet-1570	273	5	)	)	PUNCT
admet-1570	273	6	peters	peters	PROPN
admet-1570	273	7	et	et	PROPN
admet-1570	273	8	al	al	PROPN
admet-1570	273	9	.	.	PUNCT
admet-1570	274	1	[	[	X
admet-1570	274	2	46	46	NUM
admet-1570	274	3	]	]	PUNCT
admet-1570	274	4	have	have	AUX
admet-1570	274	5	developed	develop	VERB
admet-1570	274	6	a	a	DET
admet-1570	274	7	human	human	ADJ
admet-1570	274	8	recombinant	recombinant	ADJ
admet-1570	274	9	alkaline	alkaline	NOUN
admet-1570	274	10	phosphatase	phosphatase	NOUN
admet-1570	274	11	(	(	PUNCT
admet-1570	274	12	recap	recap	NOUN
admet-1570	274	13	)	)	PUNCT
admet-1570	274	14	as	as	ADP
admet-1570	274	15	a	a	DET
admet-1570	274	16	potential	potential	ADJ
admet-1570	274	17	therapeutic	therapeutic	ADJ
admet-1570	274	18	agent	agent	NOUN
admet-1570	274	19	.	.	PUNCT
admet-1570	275	1	this	this	DET
admet-1570	275	2	human	human	ADJ
admet-1570	275	3	chimera	chimera	NOUN
admet-1570	275	4	is	be	AUX
admet-1570	275	5	constructed	construct	VERB
admet-1570	275	6	from	from	ADP
admet-1570	275	7	414	414	NUM
admet-1570	275	8	amino	amino	ADJ
admet-1570	275	9	acids	acid	NOUN
admet-1570	275	10	from	from	ADP
admet-1570	275	11	the	the	DET
admet-1570	275	12	intestinal	intestinal	ADJ
admet-1570	275	13	plus	plus	CCONJ
admet-1570	275	14	70	70	NUM
admet-1570	275	15	amino	amino	NOUN
admet-1570	275	16	acids	acid	NOUN
admet-1570	275	17	from	from	ADP
admet-1570	275	18	the	the	DET
admet-1570	275	19	“	"	PUNCT
admet-1570	275	20	crown	crown	NOUN
admet-1570	275	21	”	"	PUNCT
admet-1570	275	22	domain	domain	NOUN
admet-1570	275	23	of	of	ADP
admet-1570	275	24	placental	placental	ADJ
admet-1570	275	25	alkaline	alkaline	NOUN
admet-1570	275	26	phosphatase	phosphatase	NOUN
admet-1570	275	27	[	[	X
admet-1570	275	28	47	47	NUM
admet-1570	275	29	]	]	PUNCT
admet-1570	275	30	.	.	PUNCT
admet-1570	276	1	since	since	SCONJ
admet-1570	276	2	the	the	DET
admet-1570	276	3	recap	recap	NOUN
admet-1570	276	4	pk	pk	NOUN
admet-1570	276	5	is	be	AUX
admet-1570	276	6	nearly	nearly	ADV
admet-1570	276	7	identical	identical	ADJ
admet-1570	276	8	to	to	ADP
admet-1570	276	9	purified	purify	VERB
admet-1570	276	10	bovine	bovine	ADJ
admet-1570	276	11	intestinal	intestinal	ADJ
admet-1570	276	12	alkaline	alkaline	NOUN
admet-1570	276	13	phosphatase	phosphatase	NOUN
admet-1570	276	14	[	[	X
admet-1570	276	15	48	48	NUM
admet-1570	276	16	]	]	PUNCT
admet-1570	276	17	,	,	PUNCT
admet-1570	276	18	it	it	PRON
admet-1570	276	19	can	can	AUX
admet-1570	276	20	be	be	AUX
admet-1570	276	21	assumed	assume	VERB
admet-1570	276	22	that	that	SCONJ
admet-1570	276	23	the	the	DET
admet-1570	276	24	recap	recap	NOUN
admet-1570	276	25	pk	pk	NOUN
admet-1570	276	26	is	be	AUX
admet-1570	276	27	representative	representative	NOUN
admet-1570	276	28	of	of	ADP
admet-1570	276	29	human	human	ADJ
admet-1570	276	30	intestinal	intestinal	ADJ
admet-1570	276	31	alkaline	alkaline	NOUN
admet-1570	276	32	phosphatase	phosphatase	NOUN
admet-1570	276	33	(	(	PUNCT
admet-1570	276	34	iap	iap	PROPN
admet-1570	276	35	)	)	PUNCT
admet-1570	276	36	.	.	PUNCT
admet-1570	277	1	studies	study	NOUN
admet-1570	277	2	of	of	ADP
admet-1570	277	3	recap	recap	NOUN
admet-1570	277	4	provide	provide	VERB
admet-1570	277	5	some	some	PRON
admet-1570	277	6	of	of	ADP
admet-1570	277	7	the	the	DET
admet-1570	277	8	best	good	ADJ
admet-1570	277	9	available	available	ADJ
admet-1570	277	10	human	human	ADJ
admet-1570	277	11	protein	protein	NOUN
admet-1570	277	12	enzyme	enzyme	NOUN
admet-1570	277	13	pk	pk	NOUN
admet-1570	277	14	studies	study	NOUN
admet-1570	277	15	because	because	SCONJ
admet-1570	277	16	the	the	DET
admet-1570	277	17	protein	protein	NOUN
admet-1570	277	18	is	be	AUX
admet-1570	277	19	readily	readily	ADV
admet-1570	277	20	distinguished	distinguish	VERB
admet-1570	277	21	from	from	ADP
admet-1570	277	22	the	the	DET
admet-1570	277	23	background	background	NOUN
admet-1570	277	24	endogenous	endogenous	ADJ
admet-1570	277	25	enzyme	enzyme	NOUN
admet-1570	277	26	.	.	PUNCT
admet-1570	278	1	since	since	SCONJ
admet-1570	278	2	recap	recap	NOUN
admet-1570	278	3	has	have	VERB
admet-1570	278	4	a	a	DET
admet-1570	278	5	molecular	molecular	ADJ
admet-1570	278	6	weight	weight	NOUN
admet-1570	278	7	nearly	nearly	ADV
admet-1570	278	8	identical	identical	ADJ
admet-1570	278	9	to	to	ADP
admet-1570	278	10	that	that	PRON
admet-1570	278	11	of	of	ADP
admet-1570	278	12	igg	igg	PROPN
admet-1570	278	13	,	,	PUNCT
admet-1570	278	14	it	it	PRON
admet-1570	278	15	should	should	AUX
admet-1570	278	16	have	have	VERB
admet-1570	278	17	the	the	DET
admet-1570	278	18	same	same	ADJ
admet-1570	278	19	f1	f1	NOUN
admet-1570	278	20	,	,	PUNCT
admet-1570	278	21	f2	f2	PROPN
admet-1570	278	22	,	,	PUNCT
admet-1570	278	23	l1	l1	PROPN
admet-1570	278	24	and	and	CCONJ
admet-1570	278	25	l2	l2	NOUN
admet-1570	278	26	that	that	PRON
admet-1570	278	27	were	be	AUX
admet-1570	278	28	previously	previously	ADV
admet-1570	278	29	determined	determine	VERB
admet-1570	278	30	for	for	ADP
admet-1570	278	31	igg	igg	PROPN
admet-1570	278	32	in	in	ADP
admet-1570	278	33	humans	human	NOUN
admet-1570	278	34	,	,	PUNCT
admet-1570	278	35	leaving	leave	VERB
admet-1570	278	36	only	only	ADV
admet-1570	278	37	one	one	NUM
admet-1570	278	38	adjustable	adjustable	ADJ
admet-1570	278	39	parameter	parameter	NOUN
admet-1570	278	40	,	,	PUNCT
admet-1570	278	41	clp	clp	PROPN
admet-1570	278	42	.	.	PUNCT
admet-1570	278	43	figure	figure	NOUN
admet-1570	278	44	10	10	NUM
admet-1570	278	45	shows	show	VERB
admet-1570	278	46	an	an	DET
admet-1570	278	47	attempt	attempt	NOUN
admet-1570	278	48	to	to	PART
admet-1570	278	49	fit	fit	VERB
admet-1570	278	50	the	the	DET
admet-1570	278	51	recap	recap	NOUN
admet-1570	278	52	kinetics	kinetic	NOUN
admet-1570	278	53	(	(	PUNCT
admet-1570	278	54	solid	solid	ADJ
admet-1570	278	55	circles	circle	NOUN
admet-1570	278	56	)	)	PUNCT
admet-1570	278	57	following	follow	VERB
admet-1570	278	58	a	a	DET
admet-1570	278	59	60	60	NUM
admet-1570	278	60	min	min	NOUN
admet-1570	278	61	constant	constant	ADJ
admet-1570	278	62	iv	iv	NUM
admet-1570	278	63	infusion	infusion	NOUN
admet-1570	278	64	of	of	ADP
admet-1570	278	65	1000	1000	NUM
admet-1570	278	66	u	u	NOUN
admet-1570	278	67	/	/	SYM
admet-1570	278	68	kg	kg	X
admet-1570	278	69	in	in	ADP
admet-1570	278	70	humans	human	NOUN
admet-1570	278	71	with	with	ADP
admet-1570	278	72	the	the	DET
admet-1570	278	73	convective	convective	ADJ
admet-1570	278	74	model	model	NOUN
admet-1570	278	75	(	(	PUNCT
admet-1570	278	76	figure	figure	NOUN
admet-1570	278	77	1b	1b	NUM
admet-1570	278	78	)	)	PUNCT
admet-1570	278	79	using	use	VERB
admet-1570	278	80	the	the	DET
admet-1570	278	81	igg	igg	PROPN
admet-1570	278	82	f1	f1	PROPN
admet-1570	278	83	and	and	CCONJ
admet-1570	278	84	f2	f2	PROPN
admet-1570	278	85	,	,	PUNCT
admet-1570	278	86	and	and	CCONJ
admet-1570	278	87	the	the	DET
admet-1570	278	88	human	human	ADJ
admet-1570	278	89	lymph	lymph	NOUN
admet-1570	278	90	flows	flow	VERB
admet-1570	278	91	(	(	PUNCT
admet-1570	278	92	l1	l1	NOUN
admet-1570	278	93	and	and	CCONJ
admet-1570	278	94	l2	l2	PROPN
admet-1570	278	95	)	)	PUNCT
admet-1570	278	96	,	,	PUNCT
admet-1570	278	97	adjusting	adjust	VERB
admet-1570	278	98	only	only	ADV
admet-1570	278	99	clp	clp	NOUN
admet-1570	278	100	to	to	PART
admet-1570	278	101	fit	fit	VERB
admet-1570	278	102	the	the	DET
admet-1570	278	103	early	early	ADJ
admet-1570	278	104	time	time	NOUN
admet-1570	278	105	data	datum	NOUN
admet-1570	278	106	.	.	PUNCT
admet-1570	279	1	it	it	PRON
admet-1570	279	2	can	can	AUX
admet-1570	279	3	be	be	AUX
admet-1570	279	4	seen	see	VERB
admet-1570	279	5	that	that	SCONJ
admet-1570	279	6	recap	recap	NOUN
admet-1570	279	7	has	have	AUX
admet-1570	279	8	marked	mark	VERB
admet-1570	279	9	biphasic	biphasic	ADJ
admet-1570	279	10	kinetics	kinetic	NOUN
admet-1570	279	11	that	that	PRON
admet-1570	279	12	is	be	AUX
admet-1570	279	13	very	very	ADV
admet-1570	279	14	poorly	poorly	ADV
admet-1570	279	15	fit	fit	ADJ
admet-1570	279	16	by	by	ADP
admet-1570	279	17	the	the	DET
admet-1570	279	18	model	model	NOUN
admet-1570	279	19	.	.	PUNCT
admet-1570	280	1	no	no	DET
admet-1570	280	2	reasonable	reasonable	ADJ
admet-1570	280	3	variation	variation	NOUN
admet-1570	280	4	of	of	ADP
admet-1570	280	5	the	the	DET
admet-1570	280	6	model	model	NOUN
admet-1570	280	7	parameters	parameter	NOUN
admet-1570	280	8	can	can	AUX
admet-1570	280	9	fit	fit	VERB
admet-1570	280	10	the	the	DET
admet-1570	280	11	anomalously	anomalously	ADV
admet-1570	280	12	rapid	rapid	ADJ
admet-1570	280	13	,	,	PUNCT
admet-1570	280	14	initial	initial	ADJ
admet-1570	280	15	,	,	PUNCT
admet-1570	280	16	distribution	distribution	NOUN
admet-1570	280	17	phase	phase	NOUN
admet-1570	280	18	of	of	ADP
admet-1570	280	19	the	the	DET
admet-1570	280	20	enzyme	enzyme	NOUN
admet-1570	280	21	.	.	PUNCT
admet-1570	281	1	clearly	clearly	ADV
admet-1570	281	2	,	,	PUNCT
admet-1570	281	3	a	a	DET
admet-1570	281	4	major	major	ADJ
admet-1570	281	5	modification	modification	NOUN
admet-1570	281	6	of	of	ADP
admet-1570	281	7	the	the	DET
admet-1570	281	8	protein	protein	NOUN
admet-1570	281	9	model	model	NOUN
admet-1570	281	10	in	in	ADP
admet-1570	281	11	figure	figure	NOUN
admet-1570	281	12	1b	1b	NUM
admet-1570	281	13	is	be	AUX
admet-1570	281	14	required	require	VERB
admet-1570	281	15	for	for	ADP
admet-1570	281	16	recap	recap	NOUN
admet-1570	281	17	.	.	PUNCT
admet-1570	282	1	admet	admet	PROPN
admet-1570	282	2	&	&	CCONJ
admet-1570	282	3	dmpk	dmpk	PROPN
admet-1570	282	4	11(1	11(1	NUM
admet-1570	282	5	)	)	PUNCT
admet-1570	282	6	(	(	PUNCT
admet-1570	282	7	2023	2023	NUM
admet-1570	282	8	)	)	PUNCT
admet-1570	282	9	57	57	NUM
admet-1570	282	10	-	-	SYM
admet-1570	282	11	80	80	NUM
admet-1570	282	12	protein	protein	NOUN
admet-1570	282	13	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	282	14	model	model	NOUN
admet-1570	282	15	doi	doi	NOUN
admet-1570	282	16	:	:	PUNCT
admet-1570	282	17	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	282	18	71	71	NUM
admet-1570	282	19	figure	figure	NOUN
admet-1570	282	20	10	10	NUM
admet-1570	282	21	.	.	PUNCT
admet-1570	282	22	comparison	comparison	NOUN
admet-1570	282	23	of	of	ADP
admet-1570	282	24	pk	pk	NOUN
admet-1570	282	25	physiological	physiological	ADJ
admet-1570	282	26	protein	protein	NOUN
admet-1570	282	27	model	model	NOUN
admet-1570	282	28	prediction	prediction	NOUN
admet-1570	282	29	(	(	PUNCT
admet-1570	282	30	line	line	NOUN
admet-1570	282	31	)	)	PUNCT
admet-1570	282	32	following	follow	VERB
admet-1570	282	33	a	a	DET
admet-1570	282	34	60	60	NUM
admet-1570	282	35	min	min	NOUN
admet-1570	282	36	iv	iv	NOUN
admet-1570	282	37	infusion	infusion	NOUN
admet-1570	282	38	of	of	ADP
admet-1570	282	39	recombinant	recombinant	ADJ
admet-1570	282	40	alkaline	alkaline	NOUN
admet-1570	282	41	phosphatase	phosphatase	NOUN
admet-1570	282	42	(	(	PUNCT
admet-1570	282	43	recap	recap	NOUN
admet-1570	282	44	)	)	PUNCT
admet-1570	282	45	in	in	ADP
admet-1570	282	46	the	the	DET
admet-1570	282	47	human	human	NOUN
admet-1570	282	48	versus	versus	ADP
admet-1570	282	49	experimental	experimental	ADJ
admet-1570	282	50	data	datum	NOUN
admet-1570	282	51	(	(	PUNCT
admet-1570	282	52	solid	solid	ADJ
admet-1570	282	53	circles	circle	NOUN
admet-1570	282	54	)	)	PUNCT
admet-1570	282	55	.	.	PUNCT
admet-1570	283	1	the	the	DET
admet-1570	283	2	human	human	ADJ
admet-1570	283	3	plasma	plasma	NOUN
admet-1570	283	4	-	-	PUNCT
admet-1570	283	5	tissue	tissue	NOUN
admet-1570	283	6	exchange	exchange	NOUN
admet-1570	283	7	parameters	parameter	NOUN
admet-1570	283	8	(	(	PUNCT
admet-1570	283	9	f1	f1	NOUN
admet-1570	283	10	,	,	PUNCT
admet-1570	283	11	f2	f2	PROPN
admet-1570	283	12	,	,	PUNCT
admet-1570	283	13	l1	l1	PROPN
admet-1570	283	14	,	,	PUNCT
admet-1570	283	15	l2	l2	NOUN
admet-1570	283	16	,	,	PUNCT
admet-1570	283	17	figure	figure	NOUN
admet-1570	283	18	1b	1b	NUM
admet-1570	283	19	)	)	PUNCT
admet-1570	283	20	were	be	AUX
admet-1570	283	21	assumed	assume	VERB
admet-1570	283	22	to	to	PART
admet-1570	283	23	be	be	AUX
admet-1570	283	24	identical	identical	ADJ
admet-1570	283	25	to	to	ADP
admet-1570	283	26	those	those	PRON
admet-1570	283	27	for	for	ADP
admet-1570	283	28	monoclonals	monoclonal	NOUN
admet-1570	283	29	and	and	CCONJ
admet-1570	283	30	only	only	ADV
admet-1570	283	31	the	the	DET
admet-1570	283	32	metabolic	metabolic	NOUN
admet-1570	283	33	clearance	clearance	NOUN
admet-1570	283	34	(	(	PUNCT
admet-1570	283	35	clp	clp	PROPN
admet-1570	283	36	)	)	PUNCT
admet-1570	283	37	was	be	AUX
admet-1570	283	38	adjusted	adjust	VERB
admet-1570	283	39	to	to	PART
admet-1570	283	40	try	try	VERB
admet-1570	283	41	to	to	PART
admet-1570	283	42	fit	fit	VERB
admet-1570	283	43	the	the	DET
admet-1570	283	44	early	early	ADJ
admet-1570	283	45	time	time	NOUN
admet-1570	283	46	data	datum	NOUN
admet-1570	283	47	.	.	PUNCT
admet-1570	284	1	studies	study	NOUN
admet-1570	284	2	in	in	ADP
admet-1570	284	3	the	the	DET
admet-1570	284	4	rat	rat	NOUN
admet-1570	284	5	,	,	PUNCT
admet-1570	284	6	both	both	PRON
admet-1570	284	7	in	in	ADP
admet-1570	284	8	vivo	vivo	NOUN
admet-1570	284	9	well	well	ADV
admet-1570	284	10	as	as	ADP
admet-1570	284	11	in	in	ADP
admet-1570	284	12	isolated	isolated	ADJ
admet-1570	284	13	liver	liver	NOUN
admet-1570	284	14	perfusion	perfusion	NOUN
admet-1570	284	15	studies	study	NOUN
admet-1570	284	16	,	,	PUNCT
admet-1570	284	17	have	have	AUX
admet-1570	284	18	provided	provide	VERB
admet-1570	284	19	a	a	DET
admet-1570	284	20	mechanistic	mechanistic	ADJ
admet-1570	284	21	explanation	explanation	NOUN
admet-1570	284	22	of	of	ADP
admet-1570	284	23	this	this	DET
admet-1570	284	24	striking	striking	ADJ
admet-1570	284	25	biphasic	biphasic	ADJ
admet-1570	284	26	kinetic	kinetic	ADJ
admet-1570	284	27	behavior	behavior	NOUN
admet-1570	284	28	[	[	X
admet-1570	284	29	49	49	NUM
admet-1570	284	30	-	-	SYM
admet-1570	284	31	52	52	NUM
admet-1570	284	32	]	]	PUNCT
admet-1570	284	33	.	.	PUNCT
admet-1570	285	1	alkaline	alkaline	ADJ
admet-1570	285	2	phosphatase	phosphatase	NOUN
admet-1570	285	3	is	be	AUX
admet-1570	285	4	unique	unique	ADJ
admet-1570	285	5	among	among	ADP
admet-1570	285	6	the	the	DET
admet-1570	285	7	proteins	protein	NOUN
admet-1570	285	8	under	under	ADP
admet-1570	285	9	study	study	NOUN
admet-1570	285	10	(	(	PUNCT
admet-1570	285	11	table	table	NOUN
admet-1570	285	12	1	1	NUM
admet-1570	285	13	)	)	PUNCT
admet-1570	285	14	in	in	SCONJ
admet-1570	285	15	that	that	SCONJ
admet-1570	285	16	it	it	PRON
admet-1570	285	17	is	be	AUX
admet-1570	285	18	a	a	DET
admet-1570	285	19	glycoprotein	glycoprotein	NOUN
admet-1570	285	20	whose	whose	DET
admet-1570	285	21	elimination	elimination	NOUN
admet-1570	285	22	involves	involve	VERB
admet-1570	285	23	binding	bind	VERB
admet-1570	285	24	to	to	ADP
admet-1570	285	25	the	the	DET
admet-1570	285	26	mannose	mannose	NOUN
admet-1570	285	27	and	and	CCONJ
admet-1570	285	28	galactose	galactose	NOUN
admet-1570	285	29	(	(	PUNCT
admet-1570	285	30	also	also	ADV
admet-1570	285	31	known	know	VERB
admet-1570	285	32	as	as	ADP
admet-1570	285	33	asialoglycoprotein	asialoglycoprotein	ADJ
admet-1570	285	34	)	)	PUNCT
admet-1570	285	35	liver	liver	NOUN
admet-1570	285	36	receptor	receptor	NOUN
admet-1570	285	37	.	.	PUNCT
admet-1570	286	1	the	the	DET
admet-1570	286	2	rates	rate	NOUN
admet-1570	286	3	of	of	ADP
admet-1570	286	4	both	both	CCONJ
admet-1570	286	5	the	the	DET
admet-1570	286	6	early	early	ADJ
admet-1570	286	7	(	(	PUNCT
admet-1570	286	8	distribution	distribution	NOUN
admet-1570	286	9	)	)	PUNCT
admet-1570	286	10	and	and	CCONJ
admet-1570	286	11	late	late	ADJ
admet-1570	286	12	(	(	PUNCT
admet-1570	286	13	elimination	elimination	NOUN
admet-1570	286	14	)	)	PUNCT
admet-1570	286	15	phases	phase	NOUN
admet-1570	286	16	of	of	ADP
admet-1570	286	17	the	the	DET
admet-1570	286	18	alkaline	alkaline	NOUN
admet-1570	286	19	phosphatase	phosphatase	NOUN
admet-1570	286	20	curve	curve	NOUN
admet-1570	286	21	are	be	AUX
admet-1570	286	22	dramatically	dramatically	ADV
admet-1570	286	23	reduced	reduce	VERB
admet-1570	286	24	by	by	ADP
admet-1570	286	25	the	the	DET
admet-1570	286	26	addition	addition	NOUN
admet-1570	286	27	of	of	ADP
admet-1570	286	28	asialofetuin	asialofetuin	ADJ
admet-1570	286	29	,	,	PUNCT
admet-1570	286	30	an	an	DET
admet-1570	286	31	inhibitor	inhibitor	NOUN
admet-1570	286	32	of	of	ADP
admet-1570	286	33	the	the	DET
admet-1570	286	34	asialoglycoprotein	asialoglycoprotein	ADJ
admet-1570	286	35	receptor	receptor	NOUN
admet-1570	286	36	.	.	PUNCT
admet-1570	287	1	the	the	DET
admet-1570	287	2	rat	rat	NOUN
admet-1570	287	3	results	result	NOUN
admet-1570	287	4	suggest	suggest	VERB
admet-1570	287	5	that	that	SCONJ
admet-1570	287	6	the	the	DET
admet-1570	287	7	early	early	ADJ
admet-1570	287	8	,	,	PUNCT
admet-1570	287	9	extremely	extremely	ADV
admet-1570	287	10	rapid	rapid	ADJ
admet-1570	287	11	phase	phase	NOUN
admet-1570	287	12	of	of	ADP
admet-1570	287	13	the	the	DET
admet-1570	287	14	kinetics	kinetic	NOUN
admet-1570	287	15	results	result	NOUN
admet-1570	287	16	from	from	ADP
admet-1570	287	17	alkaline	alkaline	ADJ
admet-1570	287	18	phosphatase	phosphatase	NOUN
admet-1570	287	19	attachment	attachment	NOUN
admet-1570	287	20	to	to	ADP
admet-1570	287	21	the	the	DET
admet-1570	287	22	asialoglycoprotein	asialoglycoprotein	ADJ
admet-1570	287	23	receptor	receptor	NOUN
admet-1570	287	24	,	,	PUNCT
admet-1570	287	25	most	most	ADJ
admet-1570	287	26	of	of	ADP
admet-1570	287	27	which	which	PRON
admet-1570	287	28	is	be	AUX
admet-1570	287	29	then	then	ADV
admet-1570	287	30	taken	take	VERB
admet-1570	287	31	up	up	ADP
admet-1570	287	32	by	by	ADP
admet-1570	287	33	the	the	DET
admet-1570	287	34	liver	liver	NOUN
admet-1570	287	35	cell	cell	NOUN
admet-1570	287	36	and	and	CCONJ
admet-1570	287	37	recycled	recycle	VERB
admet-1570	287	38	back	back	ADV
admet-1570	287	39	to	to	ADP
admet-1570	287	40	the	the	DET
admet-1570	287	41	plasma	plasma	NOUN
admet-1570	287	42	where	where	SCONJ
admet-1570	287	43	it	it	PRON
admet-1570	287	44	is	be	AUX
admet-1570	287	45	released	release	VERB
admet-1570	287	46	intact	intact	ADJ
admet-1570	287	47	,	,	PUNCT
admet-1570	287	48	with	with	ADP
admet-1570	287	49	little	little	ADJ
admet-1570	287	50	metabolism	metabolism	NOUN
admet-1570	287	51	.	.	PUNCT
admet-1570	288	1	figure	figure	NOUN
admet-1570	288	2	11	11	NUM
admet-1570	288	3	.	.	PUNCT
admet-1570	289	1	modified	modify	VERB
admet-1570	289	2	physiological	physiological	ADJ
admet-1570	289	3	protein	protein	NOUN
admet-1570	289	4	model	model	NOUN
admet-1570	289	5	with	with	ADP
admet-1570	289	6	the	the	DET
admet-1570	289	7	addition	addition	NOUN
admet-1570	289	8	of	of	ADP
admet-1570	289	9	a	a	DET
admet-1570	289	10	recycling	recycling	NOUN
admet-1570	289	11	liver	liver	NOUN
admet-1570	289	12	compartment	compartment	NOUN
admet-1570	289	13	with	with	ADP
admet-1570	289	14	metabolic	metabolic	NOUN
admet-1570	289	15	clearance	clearance	NOUN
admet-1570	289	16	cll	cll	PROPN
admet-1570	289	17	from	from	ADP
admet-1570	289	18	the	the	DET
admet-1570	289	19	liver	liver	NOUN
admet-1570	289	20	compartment	compartment	NOUN
admet-1570	289	21	.	.	PUNCT
admet-1570	290	1	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	291	1	d.g	d.g	PROPN
admet-1570	291	2	.	.	PROPN
admet-1570	291	3	levitt	levitt	PROPN
admet-1570	291	4	and	and	CCONJ
admet-1570	291	5	m.d	m.d	PROPN
admet-1570	291	6	.	.	PROPN
admet-1570	291	7	levitt	levitt	PROPN
admet-1570	291	8	admet	admet	PROPN
admet-1570	291	9	&	&	CCONJ
admet-1570	291	10	dmpk	dmpk	PROPN
admet-1570	291	11	11(1	11(1	NUM
admet-1570	291	12	)	)	PUNCT
admet-1570	291	13	(	(	PUNCT
admet-1570	291	14	2023	2023	NUM
admet-1570	291	15	)	)	PUNCT
admet-1570	291	16	57	57	NUM
admet-1570	291	17	-	-	SYM
admet-1570	291	18	80	80	NUM
admet-1570	291	19	72	72	NUM
admet-1570	291	20	figure	figure	NOUN
admet-1570	291	21	11	11	NUM
admet-1570	291	22	diagrams	diagram	NOUN
admet-1570	291	23	a	a	DET
admet-1570	291	24	modification	modification	NOUN
admet-1570	291	25	of	of	ADP
admet-1570	291	26	the	the	DET
admet-1570	291	27	protein	protein	NOUN
admet-1570	291	28	physiological	physiological	ADJ
admet-1570	291	29	model	model	NOUN
admet-1570	291	30	with	with	ADP
admet-1570	291	31	the	the	DET
admet-1570	291	32	addition	addition	NOUN
admet-1570	291	33	of	of	ADP
admet-1570	291	34	another	another	DET
admet-1570	291	35	compartment	compartment	NOUN
admet-1570	291	36	(	(	PUNCT
admet-1570	291	37	vl	vl	NOUN
admet-1570	291	38	,	,	PUNCT
admet-1570	291	39	cl	cl	NOUN
admet-1570	291	40	)	)	PUNCT
admet-1570	291	41	in	in	ADP
admet-1570	291	42	an	an	DET
admet-1570	291	43	attempt	attempt	NOUN
admet-1570	291	44	to	to	PART
admet-1570	291	45	account	account	VERB
admet-1570	291	46	for	for	ADP
admet-1570	291	47	this	this	DET
admet-1570	291	48	additional	additional	ADJ
admet-1570	291	49	recycling	recycling	NOUN
admet-1570	291	50	liver	liver	NOUN
admet-1570	291	51	component	component	NOUN
admet-1570	291	52	.	.	PUNCT
admet-1570	292	1	the	the	DET
admet-1570	292	2	rate	rate	NOUN
admet-1570	292	3	constant	constant	ADJ
admet-1570	292	4	k	k	PROPN
admet-1570	292	5	characterizes	characterize	VERB
admet-1570	292	6	the	the	DET
admet-1570	292	7	recycling	recycling	NOUN
admet-1570	292	8	rate	rate	NOUN
admet-1570	292	9	between	between	ADP
admet-1570	292	10	the	the	DET
admet-1570	292	11	plasma	plasma	NOUN
admet-1570	292	12	and	and	CCONJ
admet-1570	292	13	liver	liver	NOUN
admet-1570	292	14	compartment	compartment	NOUN
admet-1570	292	15	,	,	PUNCT
admet-1570	292	16	and	and	CCONJ
admet-1570	292	17	vl	vl	PROPN
admet-1570	292	18	is	be	AUX
admet-1570	292	19	the	the	DET
admet-1570	292	20	equivalent	equivalent	ADJ
admet-1570	292	21	volume	volume	NOUN
admet-1570	292	22	(	(	PUNCT
admet-1570	292	23	i.e.	i.e.	X
admet-1570	292	24	,	,	PUNCT
admet-1570	292	25	binding	binding	ADJ
admet-1570	292	26	capacity	capacity	NOUN
admet-1570	292	27	)	)	PUNCT
admet-1570	292	28	of	of	ADP
admet-1570	292	29	this	this	DET
admet-1570	292	30	compartment	compartment	NOUN
admet-1570	292	31	.	.	PUNCT
admet-1570	293	1	note	note	VERB
admet-1570	293	2	that	that	SCONJ
admet-1570	293	3	the	the	DET
admet-1570	293	4	metabolism	metabolism	NOUN
admet-1570	293	5	now	now	ADV
admet-1570	293	6	occurs	occur	VERB
admet-1570	293	7	from	from	ADP
admet-1570	293	8	the	the	DET
admet-1570	293	9	liver	liver	NOUN
admet-1570	293	10	compartment	compartment	NOUN
admet-1570	293	11	and	and	CCONJ
admet-1570	293	12	is	be	AUX
admet-1570	293	13	proportional	proportional	ADJ
admet-1570	293	14	to	to	AUX
admet-1570	293	15	cl	cl	VERB
admet-1570	293	16	and	and	CCONJ
admet-1570	293	17	is	be	AUX
admet-1570	293	18	characterized	characterize	VERB
admet-1570	293	19	by	by	ADP
admet-1570	293	20	metabolic	metabolic	NOUN
admet-1570	293	21	liver	liver	NOUN
admet-1570	293	22	clearance	clearance	NOUN
admet-1570	293	23	(	(	PUNCT
admet-1570	293	24	cll	cll	PROPN
admet-1570	293	25	)	)	PUNCT
admet-1570	293	26	.	.	PUNCT
admet-1570	294	1	although	although	SCONJ
admet-1570	294	2	there	there	PRON
admet-1570	294	3	are	be	VERB
admet-1570	294	4	7	7	NUM
admet-1570	294	5	pk	pk	NOUN
admet-1570	294	6	parameters	parameter	NOUN
admet-1570	294	7	in	in	ADP
admet-1570	294	8	figure	figure	NOUN
admet-1570	294	9	11	11	NUM
admet-1570	294	10	,	,	PUNCT
admet-1570	294	11	only	only	ADV
admet-1570	294	12	3	3	NUM
admet-1570	294	13	of	of	ADP
admet-1570	294	14	them	they	PRON
admet-1570	294	15	are	be	AUX
admet-1570	294	16	adjustable	adjustable	ADJ
admet-1570	294	17	(	(	PUNCT
admet-1570	294	18	k	k	NOUN
admet-1570	294	19	,	,	PUNCT
admet-1570	294	20	vl	vl	INTJ
admet-1570	294	21	,	,	PUNCT
admet-1570	294	22	cll	cll	PROPN
admet-1570	294	23	)	)	PUNCT
admet-1570	294	24	because	because	SCONJ
admet-1570	294	25	f1	f1	PROPN
admet-1570	294	26	,	,	PUNCT
admet-1570	294	27	f2	f2	PROPN
admet-1570	294	28	,	,	PUNCT
admet-1570	294	29	l1	l1	PROPN
admet-1570	294	30	,	,	PUNCT
admet-1570	294	31	and	and	CCONJ
admet-1570	294	32	l2	l2	NOUN
admet-1570	294	33	should	should	AUX
admet-1570	294	34	have	have	VERB
admet-1570	294	35	the	the	DET
admet-1570	294	36	same	same	ADJ
admet-1570	294	37	values	value	NOUN
admet-1570	294	38	as	as	ADP
admet-1570	294	39	the	the	DET
admet-1570	294	40	human	human	ADJ
admet-1570	294	41	monoclonal	monoclonal	NOUN
admet-1570	294	42	antibody	antibody	NOUN
admet-1570	294	43	pk	pk	NOUN
admet-1570	294	44	.	.	PUNCT
admet-1570	294	45	as	as	SCONJ
admet-1570	294	46	shown	show	VERB
admet-1570	294	47	in	in	ADP
admet-1570	294	48	figure	figure	NOUN
admet-1570	294	49	12	12	NUM
admet-1570	294	50	,	,	PUNCT
admet-1570	294	51	this	this	DET
admet-1570	294	52	modified	modify	VERB
admet-1570	294	53	model	model	NOUN
admet-1570	294	54	,	,	PUNCT
admet-1570	294	55	with	with	ADP
admet-1570	294	56	these	these	DET
admet-1570	294	57	limiting	limit	VERB
admet-1570	294	58	conditions	condition	NOUN
admet-1570	294	59	,	,	PUNCT
admet-1570	294	60	accurately	accurately	ADV
admet-1570	294	61	simulates	simulate	VERB
admet-1570	294	62	the	the	DET
admet-1570	294	63	human	human	ADJ
admet-1570	294	64	biphasic	biphasic	ADJ
admet-1570	294	65	kinetics	kinetic	NOUN
admet-1570	294	66	of	of	ADP
admet-1570	294	67	recap	recap	NOUN
admet-1570	294	68	(	(	PUNCT
admet-1570	294	69	using	use	VERB
admet-1570	294	70	model	model	NOUN
admet-1570	294	71	parameters	parameter	NOUN
admet-1570	294	72	listed	list	VERB
admet-1570	294	73	in	in	ADP
admet-1570	294	74	table	table	NOUN
admet-1570	294	75	2	2	NUM
admet-1570	294	76	)	)	PUNCT
admet-1570	294	77	.	.	PUNCT
admet-1570	295	1	the	the	DET
admet-1570	295	2	liver	liver	NOUN
admet-1570	295	3	compartment	compartment	NOUN
admet-1570	295	4	vl	vl	NOUN
admet-1570	295	5	has	have	VERB
admet-1570	295	6	a	a	DET
admet-1570	295	7	very	very	ADV
admet-1570	295	8	large	large	ADJ
admet-1570	295	9	volume	volume	NOUN
admet-1570	295	10	(	(	PUNCT
admet-1570	295	11	e.g.	e.g.	ADV
admet-1570	295	12	,	,	PUNCT
admet-1570	295	13	binding	bind	VERB
admet-1570	295	14	capacity	capacity	NOUN
admet-1570	295	15	)	)	PUNCT
admet-1570	295	16	,	,	PUNCT
admet-1570	295	17	26	26	NUM
admet-1570	295	18	times	time	NOUN
admet-1570	295	19	that	that	PRON
admet-1570	295	20	of	of	ADP
admet-1570	295	21	the	the	DET
admet-1570	295	22	plasma	plasma	NOUN
admet-1570	295	23	volume	volume	NOUN
admet-1570	295	24	,	,	PUNCT
admet-1570	295	25	and	and	CCONJ
admet-1570	295	26	rapidly	rapidly	ADV
admet-1570	295	27	exchanges	exchange	NOUN
admet-1570	295	28	(	(	PUNCT
admet-1570	295	29	k	k	NOUN
admet-1570	295	30	)	)	PUNCT
admet-1570	295	31	with	with	ADP
admet-1570	295	32	the	the	DET
admet-1570	295	33	plasma	plasma	NOUN
admet-1570	295	34	(	(	PUNCT
admet-1570	295	35	50	50	NUM
admet-1570	295	36	times	time	NOUN
admet-1570	295	37	the	the	DET
admet-1570	295	38	rate	rate	NOUN
admet-1570	295	39	of	of	ADP
admet-1570	295	40	plasma	plasma	NOUN
admet-1570	295	41	to	to	ADP
admet-1570	295	42	tissue	tissue	NOUN
admet-1570	295	43	transport	transport	NOUN
admet-1570	295	44	)	)	PUNCT
admet-1570	295	45	.	.	PUNCT
admet-1570	296	1	the	the	DET
admet-1570	296	2	fit	fit	NOUN
admet-1570	296	3	is	be	AUX
admet-1570	296	4	not	not	PART
admet-1570	296	5	perfect	perfect	ADJ
admet-1570	296	6	,	,	PUNCT
admet-1570	296	7	which	which	PRON
admet-1570	296	8	is	be	AUX
admet-1570	296	9	not	not	PART
admet-1570	296	10	surprising	surprising	ADJ
admet-1570	296	11	given	give	VERB
admet-1570	296	12	the	the	DET
admet-1570	296	13	complexity	complexity	NOUN
admet-1570	296	14	of	of	ADP
admet-1570	296	15	liver	liver	NOUN
admet-1570	296	16	recycling	recycling	NOUN
admet-1570	296	17	and	and	CCONJ
admet-1570	296	18	metabolic	metabolic	NOUN
admet-1570	296	19	processes	process	NOUN
admet-1570	296	20	.	.	PUNCT
admet-1570	297	1	the	the	DET
admet-1570	297	2	red	red	ADJ
admet-1570	297	3	line	line	NOUN
admet-1570	297	4	shows	show	VERB
admet-1570	297	5	that	that	SCONJ
admet-1570	297	6	when	when	SCONJ
admet-1570	297	7	the	the	DET
admet-1570	297	8	liver	liver	NOUN
admet-1570	297	9	exchange	exchange	NOUN
admet-1570	297	10	rate	rate	NOUN
admet-1570	297	11	k	k	PROPN
admet-1570	297	12	is	be	AUX
admet-1570	297	13	set	set	VERB
admet-1570	297	14	to	to	ADP
admet-1570	297	15	zero	zero	NUM
admet-1570	297	16	,	,	PUNCT
admet-1570	297	17	there	there	PRON
admet-1570	297	18	is	be	VERB
admet-1570	297	19	a	a	DET
admet-1570	297	20	dramatic	dramatic	ADJ
admet-1570	297	21	reduction	reduction	NOUN
admet-1570	297	22	in	in	ADP
admet-1570	297	23	both	both	CCONJ
admet-1570	297	24	the	the	DET
admet-1570	297	25	clearance	clearance	NOUN
admet-1570	297	26	and	and	CCONJ
admet-1570	297	27	tissue	tissue	NOUN
admet-1570	297	28	distribution	distribution	NOUN
admet-1570	297	29	,	,	PUNCT
admet-1570	297	30	very	very	ADV
admet-1570	297	31	similar	similar	ADJ
admet-1570	297	32	to	to	ADP
admet-1570	297	33	what	what	PRON
admet-1570	297	34	is	be	AUX
admet-1570	297	35	observed	observe	VERB
admet-1570	297	36	in	in	ADP
admet-1570	297	37	the	the	DET
admet-1570	297	38	rat	rat	NOUN
admet-1570	297	39	when	when	SCONJ
admet-1570	297	40	the	the	DET
admet-1570	297	41	asialoglycoprotein	asialoglycoprotein	ADJ
admet-1570	297	42	receptor	receptor	NOUN
admet-1570	297	43	is	be	AUX
admet-1570	297	44	competitively	competitively	ADV
admet-1570	297	45	inhibited	inhibit	VERB
admet-1570	297	46	by	by	ADP
admet-1570	297	47	asialofetuin	asialofetuin	NOUN
admet-1570	297	48	[	[	X
admet-1570	297	49	49,51	49,51	NOUN
admet-1570	297	50	]	]	X
admet-1570	297	51	.	.	PUNCT
admet-1570	298	1	the	the	DET
admet-1570	298	2	green	green	PROPN
admet-1570	298	3	dashed	dash	VERB
admet-1570	298	4	line	line	NOUN
admet-1570	298	5	(	(	PUNCT
admet-1570	298	6	figure	figure	NOUN
admet-1570	298	7	12	12	NUM
admet-1570	298	8	)	)	PUNCT
admet-1570	298	9	shows	show	VERB
admet-1570	298	10	that	that	SCONJ
admet-1570	298	11	setting	set	VERB
admet-1570	298	12	the	the	DET
admet-1570	298	13	liver	liver	NOUN
admet-1570	298	14	metabolic	metabolic	NOUN
admet-1570	298	15	clearance	clearance	NOUN
admet-1570	298	16	(	(	PUNCT
admet-1570	298	17	cll	cll	PROPN
admet-1570	298	18	)	)	PUNCT
admet-1570	298	19	to	to	ADP
admet-1570	298	20	zero	zero	NUM
admet-1570	298	21	has	have	VERB
admet-1570	298	22	only	only	ADV
admet-1570	298	23	a	a	DET
admet-1570	298	24	minor	minor	ADJ
admet-1570	298	25	effect	effect	NOUN
admet-1570	298	26	on	on	ADP
admet-1570	298	27	the	the	DET
admet-1570	298	28	early	early	ADJ
admet-1570	298	29	phase	phase	NOUN
admet-1570	298	30	kinetics	kinetic	NOUN
admet-1570	298	31	,	,	PUNCT
admet-1570	298	32	which	which	PRON
admet-1570	298	33	is	be	AUX
admet-1570	298	34	dominated	dominate	VERB
admet-1570	298	35	by	by	ADP
admet-1570	298	36	the	the	DET
admet-1570	298	37	distribution	distribution	NOUN
admet-1570	298	38	into	into	ADP
admet-1570	298	39	the	the	DET
admet-1570	298	40	liver	liver	NOUN
admet-1570	298	41	compartment	compartment	NOUN
admet-1570	298	42	.	.	PUNCT
admet-1570	299	1	figure	figure	NOUN
admet-1570	299	2	12	12	NUM
admet-1570	299	3	.	.	PUNCT
admet-1570	300	1	comparison	comparison	NOUN
admet-1570	300	2	of	of	ADP
admet-1570	300	3	physiological	physiological	ADJ
admet-1570	300	4	liver	liver	NOUN
admet-1570	300	5	recycling	recycling	NOUN
admet-1570	300	6	model	model	NOUN
admet-1570	300	7	(	(	PUNCT
admet-1570	300	8	figure	figure	NOUN
admet-1570	300	9	11	11	NUM
admet-1570	300	10	)	)	PUNCT
admet-1570	300	11	prediction	prediction	NOUN
admet-1570	300	12	(	(	PUNCT
admet-1570	300	13	black	black	ADJ
admet-1570	300	14	line	line	NOUN
admet-1570	300	15	)	)	PUNCT
admet-1570	300	16	following	follow	VERB
admet-1570	300	17	a	a	DET
admet-1570	300	18	60	60	NUM
admet-1570	300	19	min	min	NOUN
admet-1570	300	20	iv	iv	NOUN
admet-1570	300	21	infusion	infusion	NOUN
admet-1570	300	22	of	of	ADP
admet-1570	300	23	recombinant	recombinant	ADJ
admet-1570	300	24	alkaline	alkaline	NOUN
admet-1570	300	25	phosphatase	phosphatase	NOUN
admet-1570	300	26	(	(	PUNCT
admet-1570	300	27	recap	recap	NOUN
admet-1570	300	28	)	)	PUNCT
admet-1570	300	29	in	in	ADP
admet-1570	300	30	the	the	DET
admet-1570	300	31	human	human	NOUN
admet-1570	300	32	versus	versus	ADP
admet-1570	300	33	experimental	experimental	ADJ
admet-1570	300	34	data	datum	NOUN
admet-1570	300	35	(	(	PUNCT
admet-1570	300	36	solid	solid	ADJ
admet-1570	300	37	circles	circle	NOUN
admet-1570	300	38	)	)	PUNCT
admet-1570	300	39	.	.	PUNCT
admet-1570	301	1	the	the	DET
admet-1570	301	2	red	red	ADJ
admet-1570	301	3	line	line	NOUN
admet-1570	301	4	is	be	AUX
admet-1570	301	5	for	for	ADP
admet-1570	301	6	the	the	DET
admet-1570	301	7	case	case	NOUN
admet-1570	301	8	where	where	SCONJ
admet-1570	301	9	the	the	DET
admet-1570	301	10	liver	liver	NOUN
admet-1570	301	11	exchange	exchange	NOUN
admet-1570	301	12	rate	rate	NOUN
admet-1570	301	13	(	(	PUNCT
admet-1570	301	14	k	k	NOUN
admet-1570	301	15	,	,	PUNCT
admet-1570	301	16	figure	figure	NOUN
admet-1570	301	17	11	11	NUM
admet-1570	301	18	)	)	PUNCT
admet-1570	301	19	is	be	AUX
admet-1570	301	20	set	set	VERB
admet-1570	301	21	to	to	ADP
admet-1570	301	22	zero	zero	NUM
admet-1570	301	23	.	.	PUNCT
admet-1570	302	1	the	the	DET
admet-1570	302	2	green	green	PROPN
admet-1570	302	3	dashed	dash	VERB
admet-1570	302	4	line	line	NOUN
admet-1570	302	5	is	be	AUX
admet-1570	302	6	for	for	ADP
admet-1570	302	7	the	the	DET
admet-1570	302	8	case	case	NOUN
admet-1570	302	9	where	where	SCONJ
admet-1570	302	10	the	the	DET
admet-1570	302	11	liver	liver	NOUN
admet-1570	302	12	metabolic	metabolic	NOUN
admet-1570	302	13	clearance	clearance	NOUN
admet-1570	302	14	(	(	PUNCT
admet-1570	302	15	cll	cll	PROPN
admet-1570	302	16	)	)	PUNCT
admet-1570	302	17	is	be	AUX
admet-1570	302	18	set	set	VERB
admet-1570	302	19	to	to	ADP
admet-1570	302	20	zero	zero	NUM
admet-1570	302	21	.	.	PUNCT
admet-1570	303	1	an	an	DET
admet-1570	303	2	interesting	interesting	ADJ
admet-1570	303	3	test	test	NOUN
admet-1570	303	4	of	of	ADP
admet-1570	303	5	this	this	DET
admet-1570	303	6	pk	pk	NOUN
admet-1570	303	7	model	model	NOUN
admet-1570	303	8	is	be	AUX
admet-1570	303	9	to	to	PART
admet-1570	303	10	see	see	VERB
admet-1570	303	11	if	if	SCONJ
admet-1570	303	12	it	it	PRON
admet-1570	303	13	can	can	AUX
admet-1570	303	14	mimic	mimic	VERB
admet-1570	303	15	the	the	DET
admet-1570	303	16	well	well	ADV
admet-1570	303	17	-	-	PUNCT
admet-1570	303	18	established	establish	VERB
admet-1570	303	19	,	,	PUNCT
admet-1570	303	20	transient	transient	ADJ
admet-1570	303	21	clinical	clinical	ADJ
admet-1570	303	22	elevations	elevation	NOUN
admet-1570	303	23	in	in	ADP
admet-1570	303	24	plasma	plasma	NOUN
admet-1570	303	25	intestinal	intestinal	ADJ
admet-1570	303	26	alkaline	alkaline	NOUN
admet-1570	303	27	phosphatase	phosphatase	NOUN
admet-1570	303	28	(	(	PUNCT
admet-1570	303	29	iap	iap	PROPN
admet-1570	303	30	)	)	PUNCT
admet-1570	303	31	that	that	PRON
admet-1570	303	32	follow	follow	VERB
admet-1570	303	33	the	the	DET
admet-1570	303	34	ingestion	ingestion	NOUN
admet-1570	303	35	of	of	ADP
admet-1570	303	36	a	a	DET
admet-1570	303	37	high	high	ADJ
admet-1570	303	38	-	-	PUNCT
admet-1570	303	39	fat	fat	NOUN
admet-1570	303	40	(	(	PUNCT
admet-1570	303	41	but	but	CCONJ
admet-1570	303	42	not	not	PART
admet-1570	303	43	protein	protein	NOUN
admet-1570	303	44	or	or	CCONJ
admet-1570	303	45	carbohydrate	carbohydrate	VERB
admet-1570	303	46	)	)	PUNCT
admet-1570	303	47	meal	meal	NOUN
admet-1570	303	48	[	[	X
admet-1570	303	49	53	53	NUM
admet-1570	303	50	]	]	PUNCT
admet-1570	303	51	.	.	PUNCT
admet-1570	304	1	there	there	PRON
admet-1570	304	2	is	be	VERB
admet-1570	304	3	a	a	DET
admet-1570	304	4	large	large	ADJ
admet-1570	304	5	individual	individual	ADJ
admet-1570	304	6	variation	variation	NOUN
admet-1570	304	7	in	in	ADP
admet-1570	304	8	these	these	DET
admet-1570	304	9	fluctuations	fluctuation	NOUN
admet-1570	304	10	,	,	PUNCT
admet-1570	304	11	with	with	ADP
admet-1570	304	12	those	those	PRON
admet-1570	304	13	who	who	PRON
admet-1570	304	14	are	be	AUX
admet-1570	304	15	red	red	ADJ
admet-1570	304	16	blood	blood	NOUN
admet-1570	304	17	cell	cell	NOUN
admet-1570	304	18	b	b	NOUN
admet-1570	304	19	or	or	CCONJ
admet-1570	304	20	o	o	NOUN
admet-1570	304	21	antigen	antigen	NOUN
admet-1570	304	22	secretors	secretor	NOUN
admet-1570	304	23	having	have	VERB
admet-1570	304	24	much	much	ADV
admet-1570	304	25	greater	great	ADJ
admet-1570	304	26	iap	iap	PROPN
admet-1570	304	27	release	release	NOUN
admet-1570	304	28	.	.	PUNCT
admet-1570	305	1	domar	domar	PROPN
admet-1570	305	2	et	et	PROPN
admet-1570	305	3	al	al	PROPN
admet-1570	305	4	.	.	PUNCT
admet-1570	306	1	[	[	X
admet-1570	306	2	53	53	NUM
admet-1570	306	3	]	]	PUNCT
admet-1570	306	4	have	have	AUX
admet-1570	306	5	quantitated	quantitate	VERB
admet-1570	306	6	these	these	DET
admet-1570	306	7	fluctuations	fluctuation	NOUN
admet-1570	306	8	following	follow	VERB
admet-1570	306	9	a	a	DET
admet-1570	306	10	standard	standard	ADJ
admet-1570	306	11	high	high	ADJ
admet-1570	306	12	-	-	PUNCT
admet-1570	306	13	fat	fat	NOUN
admet-1570	306	14	meal	meal	NOUN
admet-1570	306	15	.	.	PUNCT
admet-1570	307	1	interestingly	interestingly	ADV
admet-1570	307	2	,	,	PUNCT
admet-1570	307	3	they	they	PRON
admet-1570	307	4	have	have	AUX
admet-1570	307	5	shown	show	VERB
admet-1570	307	6	that	that	SCONJ
admet-1570	307	7	the	the	DET
admet-1570	307	8	baseline	baseline	NOUN
admet-1570	307	9	(	(	PUNCT
admet-1570	307	10	fasting	fasting	NOUN
admet-1570	307	11	)	)	PUNCT
admet-1570	307	12	iap	iap	PROPN
admet-1570	307	13	increases	increase	VERB
admet-1570	307	14	proportionally	proportionally	ADV
admet-1570	307	15	to	to	ADP
admet-1570	307	16	the	the	DET
admet-1570	307	17	peak	peak	NOUN
admet-1570	307	18	increase	increase	NOUN
admet-1570	307	19	and	and	CCONJ
admet-1570	307	20	that	that	SCONJ
admet-1570	307	21	secretors	secretor	NOUN
admet-1570	307	22	with	with	ADP
admet-1570	307	23	high	high	ADJ
admet-1570	307	24	fatstimulated	fatstimulate	VERB
admet-1570	307	25	values	value	NOUN
admet-1570	307	26	have	have	AUX
admet-1570	307	27	fasting	fast	VERB
admet-1570	307	28	iap	iap	PROPN
admet-1570	307	29	about	about	ADV
admet-1570	307	30	10	10	NUM
admet-1570	307	31	times	time	NOUN
admet-1570	307	32	greater	great	ADJ
admet-1570	307	33	than	than	ADP
admet-1570	307	34	non	non	NOUN
admet-1570	307	35	-	-	NOUN
admet-1570	307	36	secretors	secretor	NOUN
admet-1570	307	37	with	with	ADP
admet-1570	307	38	small	small	ADJ
admet-1570	307	39	fluctuations	fluctuation	NOUN
admet-1570	307	40	,	,	PUNCT
admet-1570	307	41	strongly	strongly	ADV
admet-1570	307	42	suggesting	suggest	VERB
admet-1570	307	43	that	that	SCONJ
admet-1570	307	44	the	the	DET
admet-1570	307	45	intestinal	intestinal	ADJ
admet-1570	307	46	iap	iap	PROPN
admet-1570	307	47	release	release	PROPN
admet-1570	307	48	following	follow	VERB
admet-1570	307	49	a	a	DET
admet-1570	307	50	fatty	fatty	NOUN
admet-1570	307	51	meal	meal	NOUN
admet-1570	307	52	is	be	AUX
admet-1570	307	53	the	the	DET
admet-1570	307	54	sole	sole	ADJ
admet-1570	307	55	supplier	supplier	NOUN
admet-1570	307	56	and	and	CCONJ
admet-1570	307	57	determinant	determinant	ADJ
admet-1570	307	58	of	of	ADP
admet-1570	307	59	plasma	plasma	PROPN
admet-1570	307	60	iap	iap	PROPN
admet-1570	307	61	.	.	PUNCT
admet-1570	308	1	admet	admet	PROPN
admet-1570	308	2	&	&	CCONJ
admet-1570	308	3	dmpk	dmpk	PROPN
admet-1570	308	4	11(1	11(1	NUM
admet-1570	308	5	)	)	PUNCT
admet-1570	308	6	(	(	PUNCT
admet-1570	308	7	2023	2023	NUM
admet-1570	308	8	)	)	PUNCT
admet-1570	308	9	57	57	NUM
admet-1570	308	10	-	-	SYM
admet-1570	308	11	80	80	NUM
admet-1570	308	12	protein	protein	NOUN
admet-1570	308	13	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	308	14	model	model	NOUN
admet-1570	308	15	doi	doi	NOUN
admet-1570	308	16	:	:	PUNCT
admet-1570	308	17	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	308	18	73	73	NUM
admet-1570	308	19	we	we	PRON
admet-1570	308	20	tried	try	VERB
admet-1570	308	21	to	to	PART
admet-1570	308	22	fit	fit	VERB
admet-1570	308	23	the	the	DET
admet-1570	308	24	data	datum	NOUN
admet-1570	308	25	of	of	ADP
admet-1570	308	26	domar	domar	PROPN
admet-1570	308	27	et	et	PROPN
admet-1570	308	28	al	al	PROPN
admet-1570	308	29	.	.	PUNCT
admet-1570	309	1	[	[	X
admet-1570	309	2	53	53	NUM
admet-1570	309	3	]	]	PUNCT
admet-1570	309	4	with	with	ADP
admet-1570	309	5	the	the	DET
admet-1570	309	6	modified	modify	VERB
admet-1570	309	7	pk	pk	NOUN
admet-1570	309	8	model	model	NOUN
admet-1570	309	9	(	(	PUNCT
admet-1570	309	10	figure	figure	NOUN
admet-1570	309	11	11	11	NUM
admet-1570	309	12	)	)	PUNCT
admet-1570	309	13	using	use	VERB
admet-1570	309	14	the	the	DET
admet-1570	309	15	model	model	NOUN
admet-1570	309	16	parameters	parameter	NOUN
admet-1570	309	17	determined	determine	VERB
admet-1570	309	18	above	above	ADP
admet-1570	309	19	for	for	ADP
admet-1570	309	20	recap	recap	NOUN
admet-1570	309	21	,	,	PUNCT
admet-1570	309	22	which	which	PRON
admet-1570	309	23	is	be	AUX
admet-1570	309	24	representative	representative	NOUN
admet-1570	309	25	of	of	ADP
admet-1570	309	26	iap	iap	PROPN
admet-1570	309	27	.	.	PUNCT
admet-1570	310	1	we	we	PRON
admet-1570	310	2	assumed	assume	VERB
admet-1570	310	3	that	that	SCONJ
admet-1570	310	4	following	follow	VERB
admet-1570	310	5	a	a	DET
admet-1570	310	6	highfat	highfat	NOUN
admet-1570	310	7	meal	meal	NOUN
admet-1570	310	8	,	,	PUNCT
admet-1570	310	9	iap	iap	PROPN
admet-1570	310	10	was	be	AUX
admet-1570	310	11	released	release	VERB
admet-1570	310	12	into	into	ADP
admet-1570	310	13	the	the	DET
admet-1570	310	14	tissue	tissue	NOUN
admet-1570	310	15	volume	volume	NOUN
admet-1570	310	16	v2	v2	PROPN
admet-1570	310	17	(	(	PUNCT
admet-1570	310	18	figure	figure	NOUN
admet-1570	310	19	1b	1b	NUM
admet-1570	310	20	)	)	PUNCT
admet-1570	310	21	,	,	PUNCT
admet-1570	310	22	which	which	PRON
admet-1570	310	23	,	,	PUNCT
admet-1570	310	24	as	as	SCONJ
admet-1570	310	25	discussed	discuss	VERB
admet-1570	310	26	above	above	ADV
admet-1570	310	27	,	,	PUNCT
admet-1570	310	28	presumably	presumably	ADV
admet-1570	310	29	corresponds	correspond	VERB
admet-1570	310	30	to	to	ADP
admet-1570	310	31	the	the	DET
admet-1570	310	32	gi	gi	NOUN
admet-1570	310	33	tract	tract	NOUN
admet-1570	310	34	,	,	PUNCT
admet-1570	310	35	at	at	ADP
admet-1570	310	36	a	a	DET
admet-1570	310	37	constant	constant	ADJ
admet-1570	310	38	rate	rate	NOUN
admet-1570	310	39	for	for	ADP
admet-1570	310	40	120	120	NUM
admet-1570	310	41	minutes	minute	NOUN
admet-1570	310	42	,	,	PUNCT
admet-1570	310	43	simulating	simulate	VERB
admet-1570	310	44	the	the	DET
admet-1570	310	45	release	release	NOUN
admet-1570	310	46	of	of	ADP
admet-1570	310	47	iap	iap	PROPN
admet-1570	310	48	into	into	ADP
admet-1570	310	49	the	the	DET
admet-1570	310	50	intestinal	intestinal	ADJ
admet-1570	310	51	interstitial	interstitial	ADJ
admet-1570	310	52	space	space	NOUN
admet-1570	310	53	following	follow	VERB
admet-1570	310	54	a	a	DET
admet-1570	310	55	high	high	ADJ
admet-1570	310	56	-	-	PUNCT
admet-1570	310	57	fat	fat	NOUN
admet-1570	310	58	meal	meal	NOUN
admet-1570	310	59	.	.	PUNCT
admet-1570	311	1	in	in	ADP
admet-1570	311	2	order	order	NOUN
admet-1570	311	3	to	to	PART
admet-1570	311	4	compare	compare	VERB
admet-1570	311	5	the	the	DET
admet-1570	311	6	results	result	NOUN
admet-1570	311	7	with	with	ADP
admet-1570	311	8	that	that	PRON
admet-1570	311	9	of	of	ADP
admet-1570	311	10	domar	domar	PROPN
admet-1570	311	11	et	et	PROPN
admet-1570	311	12	al	al	PROPN
admet-1570	311	13	.	.	PROPN
admet-1570	312	1	for	for	ADP
admet-1570	312	2	subjects	subject	NOUN
admet-1570	312	3	that	that	PRON
admet-1570	312	4	have	have	AUX
admet-1570	312	5	established	establish	VERB
admet-1570	312	6	steady	steady	ADJ
admet-1570	312	7	-	-	PUNCT
admet-1570	312	8	state	state	NOUN
admet-1570	312	9	iap	iap	PROPN
admet-1570	312	10	levels	level	NOUN
admet-1570	312	11	,	,	PUNCT
admet-1570	312	12	this	this	DET
admet-1570	312	13	120	120	NUM
admet-1570	312	14	-	-	PUNCT
admet-1570	312	15	minute	minute	NOUN
admet-1570	312	16	input	input	NOUN
admet-1570	312	17	was	be	AUX
admet-1570	312	18	repeated	repeat	VERB
admet-1570	312	19	at	at	ADP
admet-1570	312	20	24	24	NUM
admet-1570	312	21	-	-	PUNCT
admet-1570	312	22	hour	hour	NOUN
admet-1570	312	23	intervals	interval	NOUN
admet-1570	312	24	until	until	SCONJ
admet-1570	312	25	a	a	DET
admet-1570	312	26	steady	steady	ADJ
admet-1570	312	27	state	state	NOUN
admet-1570	312	28	was	be	AUX
admet-1570	312	29	established	establish	VERB
admet-1570	312	30	.	.	PUNCT
admet-1570	313	1	figure	figure	NOUN
admet-1570	313	2	13	13	NUM
admet-1570	313	3	shows	show	VERB
admet-1570	313	4	the	the	DET
admet-1570	313	5	comparison	comparison	NOUN
admet-1570	313	6	of	of	ADP
admet-1570	313	7	our	our	PRON
admet-1570	313	8	pk	pk	NOUN
admet-1570	313	9	model	model	NOUN
admet-1570	313	10	predictions	prediction	NOUN
admet-1570	313	11	to	to	ADP
admet-1570	313	12	the	the	DET
admet-1570	313	13	clinical	clinical	ADJ
admet-1570	313	14	data	datum	NOUN
admet-1570	313	15	of	of	ADP
admet-1570	313	16	domar	domar	PROPN
admet-1570	313	17	et	et	PROPN
admet-1570	313	18	al	al	PROPN
admet-1570	313	19	.	.	PUNCT
admet-1570	314	1	[	[	X
admet-1570	314	2	53	53	NUM
admet-1570	314	3	]	]	PUNCT
admet-1570	314	4	for	for	ADP
admet-1570	314	5	one	one	NUM
admet-1570	314	6	of	of	ADP
admet-1570	314	7	their	their	PRON
admet-1570	314	8	subjects	subject	NOUN
admet-1570	314	9	(	(	PUNCT
admet-1570	314	10	there	there	PRON
admet-1570	314	11	was	be	VERB
admet-1570	314	12	a	a	DET
admet-1570	314	13	large	large	ADJ
admet-1570	314	14	subject	subject	NOUN
admet-1570	314	15	-	-	PUNCT
admet-1570	314	16	to	to	ADP
admet-1570	314	17	-	-	PUNCT
admet-1570	314	18	subject	subject	NOUN
admet-1570	314	19	variation	variation	NOUN
admet-1570	314	20	)	)	PUNCT
admet-1570	314	21	.	.	PUNCT
admet-1570	315	1	given	give	VERB
admet-1570	315	2	the	the	DET
admet-1570	315	3	crudeness	crudeness	NOUN
admet-1570	315	4	of	of	ADP
admet-1570	315	5	our	our	PRON
admet-1570	315	6	model	model	NOUN
admet-1570	315	7	,	,	PUNCT
admet-1570	315	8	the	the	DET
admet-1570	315	9	agreement	agreement	NOUN
admet-1570	315	10	with	with	ADP
admet-1570	315	11	the	the	DET
admet-1570	315	12	data	data	NOUN
admet-1570	315	13	is	be	AUX
admet-1570	315	14	relatively	relatively	ADV
admet-1570	315	15	good	good	ADJ
admet-1570	315	16	.	.	PUNCT
admet-1570	316	1	of	of	ADP
admet-1570	316	2	special	special	ADJ
admet-1570	316	3	significance	significance	NOUN
admet-1570	316	4	is	be	AUX
admet-1570	316	5	the	the	DET
admet-1570	316	6	fact	fact	NOUN
admet-1570	316	7	that	that	SCONJ
admet-1570	316	8	both	both	CCONJ
admet-1570	316	9	the	the	DET
admet-1570	316	10	size	size	NOUN
admet-1570	316	11	of	of	ADP
admet-1570	316	12	the	the	DET
admet-1570	316	13	iap	iap	PROPN
admet-1570	316	14	fluctuations	fluctuation	NOUN
admet-1570	316	15	and	and	CCONJ
admet-1570	316	16	the	the	DET
admet-1570	316	17	corresponding	corresponding	ADJ
admet-1570	316	18	basal	basal	ADJ
admet-1570	316	19	fasting	fasting	NOUN
admet-1570	316	20	value	value	NOUN
admet-1570	316	21	(	(	PUNCT
admet-1570	316	22	minimums	minimum	NOUN
admet-1570	316	23	in	in	ADP
admet-1570	316	24	the	the	DET
admet-1570	316	25	plot	plot	NOUN
admet-1570	316	26	)	)	PUNCT
admet-1570	316	27	are	be	AUX
admet-1570	316	28	in	in	ADP
admet-1570	316	29	good	good	ADJ
admet-1570	316	30	agreement	agreement	NOUN
admet-1570	316	31	with	with	ADP
admet-1570	316	32	the	the	DET
admet-1570	316	33	clinically	clinically	ADV
admet-1570	316	34	observed	observe	VERB
admet-1570	316	35	values	value	NOUN
admet-1570	316	36	.	.	PUNCT
admet-1570	317	1	this	this	PRON
admet-1570	317	2	strongly	strongly	ADV
admet-1570	317	3	suggests	suggest	VERB
admet-1570	317	4	that	that	SCONJ
admet-1570	317	5	the	the	DET
admet-1570	317	6	fasting	fasting	NOUN
admet-1570	317	7	value	value	NOUN
admet-1570	317	8	is	be	AUX
admet-1570	317	9	entirely	entirely	ADV
admet-1570	317	10	the	the	DET
admet-1570	317	11	result	result	NOUN
admet-1570	317	12	of	of	ADP
admet-1570	317	13	the	the	DET
admet-1570	317	14	amount	amount	NOUN
admet-1570	317	15	of	of	ADP
admet-1570	317	16	iap	iap	PROPN
admet-1570	317	17	released	release	VERB
admet-1570	317	18	during	during	ADP
admet-1570	317	19	fatty	fatty	NOUN
admet-1570	317	20	meals	meal	NOUN
admet-1570	317	21	.	.	PUNCT
admet-1570	318	1	for	for	ADP
admet-1570	318	2	the	the	DET
admet-1570	318	3	subject	subject	NOUN
admet-1570	318	4	in	in	ADP
admet-1570	318	5	figure	figure	NOUN
admet-1570	318	6	13	13	NUM
admet-1570	318	7	,	,	PUNCT
admet-1570	318	8	a	a	DET
admet-1570	318	9	total	total	NOUN
admet-1570	318	10	of	of	ADP
admet-1570	318	11	360	360	NUM
admet-1570	318	12	iu	iu	ADP
admet-1570	318	13	was	be	AUX
admet-1570	318	14	released	release	VERB
admet-1570	318	15	with	with	ADP
admet-1570	318	16	each	each	DET
admet-1570	318	17	meal	meal	NOUN
admet-1570	318	18	,	,	PUNCT
admet-1570	318	19	quantitating	quantitate	VERB
admet-1570	318	20	the	the	DET
admet-1570	318	21	daily	daily	PROPN
admet-1570	318	22	human	human	PROPN
admet-1570	318	23	iap	iap	PROPN
admet-1570	318	24	release	release	PROPN
admet-1570	318	25	.	.	PUNCT
admet-1570	319	1	figure	figure	NOUN
admet-1570	319	2	13	13	NUM
admet-1570	319	3	.	.	PUNCT
admet-1570	320	1	comparison	comparison	NOUN
admet-1570	320	2	of	of	ADP
admet-1570	320	3	physiological	physiological	ADJ
admet-1570	320	4	liver	liver	NOUN
admet-1570	320	5	recycling	recycling	NOUN
admet-1570	320	6	model	model	NOUN
admet-1570	320	7	(	(	PUNCT
admet-1570	320	8	figure	figure	NOUN
admet-1570	320	9	11	11	NUM
admet-1570	320	10	)	)	PUNCT
admet-1570	320	11	simulation	simulation	NOUN
admet-1570	320	12	of	of	ADP
admet-1570	320	13	the	the	DET
admet-1570	320	14	intestinal	intestinal	ADJ
admet-1570	320	15	release	release	NOUN
admet-1570	320	16	of	of	ADP
admet-1570	320	17	intestinal	intestinal	ADJ
admet-1570	320	18	alkaline	alkaline	NOUN
admet-1570	320	19	phosphatase	phosphatase	NOUN
admet-1570	320	20	following	follow	VERB
admet-1570	320	21	a	a	DET
admet-1570	320	22	high	high	ADJ
admet-1570	320	23	-	-	PUNCT
admet-1570	320	24	fat	fat	NOUN
admet-1570	320	25	meal	meal	NOUN
admet-1570	320	26	every	every	DET
admet-1570	320	27	24	24	NUM
admet-1570	320	28	hours	hour	NOUN
admet-1570	320	29	(	(	PUNCT
admet-1570	320	30	line	line	NOUN
admet-1570	320	31	)	)	PUNCT
admet-1570	320	32	versus	versus	ADP
admet-1570	320	33	the	the	DET
admet-1570	320	34	experimental	experimental	ADJ
admet-1570	320	35	data	datum	NOUN
admet-1570	320	36	of	of	ADP
admet-1570	320	37	domar	domar	PROPN
admet-1570	320	38	et	et	PROPN
admet-1570	320	39	al	al	PROPN
admet-1570	320	40	.	.	PUNCT
admet-1570	321	1	(	(	PUNCT
admet-1570	321	2	solid	solid	ADJ
admet-1570	321	3	circles	circle	NOUN
admet-1570	321	4	)	)	PUNCT
admet-1570	321	5	.	.	PUNCT
admet-1570	322	1	there	there	PRON
admet-1570	322	2	are	be	VERB
admet-1570	322	3	at	at	ADV
admet-1570	322	4	least	least	ADJ
admet-1570	322	5	4	4	NUM
admet-1570	322	6	gene	gene	NOUN
admet-1570	322	7	loci	locus	NOUN
admet-1570	322	8	coding	code	VERB
admet-1570	322	9	4	4	NUM
admet-1570	322	10	different	different	ADJ
admet-1570	322	11	tissue	tissue	NOUN
admet-1570	322	12	-	-	PUNCT
admet-1570	322	13	specific	specific	ADJ
admet-1570	322	14	alkaline	alkaline	NOUN
admet-1570	322	15	phosphatase	phosphatase	NOUN
admet-1570	322	16	isoenzymes	isoenzyme	NOUN
admet-1570	322	17	:	:	PUNCT
admet-1570	322	18	1	1	NUM
admet-1570	322	19	)	)	PUNCT
admet-1570	322	20	intestine	intestine	NOUN
admet-1570	322	21	,	,	PUNCT
admet-1570	322	22	2	2	X
admet-1570	322	23	)	)	PUNCT
admet-1570	322	24	liver	liver	NOUN
admet-1570	322	25	/	/	SYM
admet-1570	322	26	bone	bone	NOUN
admet-1570	322	27	/	/	SYM
admet-1570	322	28	kidney	kidney	NOUN
admet-1570	322	29	,	,	PUNCT
admet-1570	322	30	3	3	NUM
admet-1570	322	31	)	)	PUNCT
admet-1570	322	32	placenta	placenta	NOUN
admet-1570	322	33	,	,	PUNCT
admet-1570	322	34	and	and	CCONJ
admet-1570	322	35	4	4	X
admet-1570	322	36	)	)	PUNCT
admet-1570	322	37	germ	germ	NOUN
admet-1570	322	38	cell	cell	NOUN
admet-1570	322	39	[	[	X
admet-1570	322	40	49,54	49,54	NUM
admet-1570	322	41	]	]	X
admet-1570	322	42	.	.	PUNCT
admet-1570	323	1	clinical	clinical	ADJ
admet-1570	323	2	observations	observation	NOUN
admet-1570	323	3	indicate	indicate	VERB
admet-1570	323	4	that	that	SCONJ
admet-1570	323	5	the	the	DET
admet-1570	323	6	intestinal	intestinal	ADJ
admet-1570	323	7	form	form	NOUN
admet-1570	323	8	has	have	VERB
admet-1570	323	9	the	the	DET
admet-1570	323	10	shortest	short	ADJ
admet-1570	323	11	half	half	ADJ
admet-1570	323	12	-	-	PUNCT
admet-1570	323	13	live	live	ADJ
admet-1570	323	14	(	(	PUNCT
admet-1570	323	15	most	most	ADV
admet-1570	323	16	rapid	rapid	ADJ
admet-1570	323	17	clearance	clearance	NOUN
admet-1570	323	18	)	)	PUNCT
admet-1570	323	19	placental	placental	NOUN
admet-1570	323	20	the	the	DET
admet-1570	323	21	longest	long	ADJ
admet-1570	323	22	,	,	PUNCT
admet-1570	323	23	with	with	SCONJ
admet-1570	323	24	the	the	DET
admet-1570	323	25	liver	liver	NOUN
admet-1570	323	26	/	/	SYM
admet-1570	323	27	bone	bone	NOUN
admet-1570	323	28	/	/	SYM
admet-1570	323	29	kidney	kidney	NOUN
admet-1570	323	30	isoenzyme	isoenzyme	NOUN
admet-1570	323	31	intermediate	intermediate	ADJ
admet-1570	323	32	,	,	PUNCT
admet-1570	323	33	a	a	DET
admet-1570	323	34	finding	finding	NOUN
admet-1570	323	35	consistent	consistent	ADJ
admet-1570	323	36	with	with	ADP
admet-1570	323	37	pk	pk	NOUN
admet-1570	323	38	measurements	measurement	NOUN
admet-1570	323	39	in	in	ADP
admet-1570	323	40	the	the	DET
admet-1570	323	41	rat	rat	NOUN
admet-1570	323	42	[	[	X
admet-1570	323	43	49	49	NUM
admet-1570	323	44	]	]	PUNCT
admet-1570	323	45	.	.	PUNCT
admet-1570	324	1	based	base	VERB
admet-1570	324	2	on	on	ADP
admet-1570	324	3	the	the	DET
admet-1570	324	4	pk	pk	NOUN
admet-1570	324	5	model	model	NOUN
admet-1570	324	6	developed	develop	VERB
admet-1570	324	7	for	for	ADP
admet-1570	324	8	recap	recap	NOUN
admet-1570	324	9	(	(	PUNCT
admet-1570	324	10	figure	figure	NOUN
admet-1570	324	11	11	11	NUM
admet-1570	324	12	)	)	PUNCT
admet-1570	324	13	,	,	PUNCT
admet-1570	324	14	one	one	PRON
admet-1570	324	15	would	would	AUX
admet-1570	324	16	predict	predict	VERB
admet-1570	324	17	that	that	SCONJ
admet-1570	324	18	both	both	CCONJ
admet-1570	324	19	the	the	DET
admet-1570	324	20	early	early	ADJ
admet-1570	324	21	phase	phase	NOUN
admet-1570	324	22	(	(	PUNCT
admet-1570	324	23	recycling	recycling	NOUN
admet-1570	324	24	)	)	PUNCT
admet-1570	324	25	and	and	CCONJ
admet-1570	324	26	late	late	ADJ
admet-1570	324	27	phase	phase	NOUN
admet-1570	324	28	(	(	PUNCT
admet-1570	324	29	metabolism	metabolism	NOUN
admet-1570	324	30	)	)	PUNCT
admet-1570	324	31	of	of	ADP
admet-1570	324	32	the	the	DET
admet-1570	324	33	biphasic	biphasic	ADJ
admet-1570	324	34	kinetics	kinetic	NOUN
admet-1570	324	35	should	should	AUX
admet-1570	324	36	be	be	AUX
admet-1570	324	37	proportional	proportional	ADJ
admet-1570	324	38	to	to	ADP
admet-1570	324	39	the	the	DET
admet-1570	324	40	affinity	affinity	NOUN
admet-1570	324	41	for	for	ADP
admet-1570	324	42	the	the	DET
admet-1570	324	43	asialoglycoprotein	asialoglycoprotein	ADJ
admet-1570	324	44	receptor	receptor	NOUN
admet-1570	324	45	,	,	PUNCT
admet-1570	324	46	which	which	PRON
admet-1570	324	47	depends	depend	VERB
admet-1570	324	48	on	on	ADP
admet-1570	324	49	the	the	DET
admet-1570	324	50	number	number	NOUN
admet-1570	324	51	of	of	ADP
admet-1570	324	52	glycan	glycan	NOUN
admet-1570	324	53	chains	chain	NOUN
admet-1570	324	54	and	and	CCONJ
admet-1570	324	55	their	their	PRON
admet-1570	324	56	degree	degree	NOUN
admet-1570	324	57	of	of	ADP
admet-1570	324	58	sialyation	sialyation	NOUN
admet-1570	324	59	.	.	PUNCT
admet-1570	325	1	this	this	PRON
admet-1570	325	2	is	be	AUX
admet-1570	325	3	consistent	consistent	ADJ
admet-1570	325	4	with	with	ADP
admet-1570	325	5	the	the	DET
admet-1570	325	6	low	low	ADJ
admet-1570	325	7	clearance	clearance	NOUN
admet-1570	325	8	of	of	ADP
admet-1570	325	9	the	the	DET
admet-1570	325	10	placental	placental	ADJ
admet-1570	325	11	alkaline	alkaline	NOUN
admet-1570	325	12	phosphatase	phosphatase	NOUN
admet-1570	325	13	,	,	PUNCT
admet-1570	325	14	which	which	PRON
admet-1570	325	15	has	have	VERB
admet-1570	325	16	only	only	ADV
admet-1570	325	17	one	one	NUM
admet-1570	325	18	glycan	glycan	NOUN
admet-1570	325	19	chain	chain	NOUN
admet-1570	325	20	,	,	PUNCT
admet-1570	325	21	of	of	ADP
admet-1570	325	22	which	which	PRON
admet-1570	325	23	more	more	ADJ
admet-1570	325	24	than	than	ADP
admet-1570	325	25	50	50	NUM
admet-1570	325	26	%	%	NOUN
admet-1570	325	27	are	be	AUX
admet-1570	325	28	sialyated	sialyate	VERB
admet-1570	325	29	[	[	X
admet-1570	325	30	55	55	NUM
admet-1570	325	31	]	]	PUNCT
admet-1570	325	32	.	.	PUNCT
admet-1570	326	1	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	327	1	d.g	d.g	PROPN
admet-1570	327	2	.	.	PROPN
admet-1570	327	3	levitt	levitt	PROPN
admet-1570	327	4	and	and	CCONJ
admet-1570	327	5	m.d	m.d	PROPN
admet-1570	327	6	.	.	PROPN
admet-1570	327	7	levitt	levitt	PROPN
admet-1570	327	8	admet	admet	PROPN
admet-1570	327	9	&	&	CCONJ
admet-1570	327	10	dmpk	dmpk	PROPN
admet-1570	327	11	11(1	11(1	NUM
admet-1570	327	12	)	)	PUNCT
admet-1570	327	13	(	(	PUNCT
admet-1570	327	14	2023	2023	NUM
admet-1570	327	15	)	)	PUNCT
admet-1570	327	16	57	57	NUM
admet-1570	327	17	-	-	SYM
admet-1570	327	18	80	80	NUM
admet-1570	327	19	74	74	NUM
admet-1570	327	20	figure	figure	NOUN
admet-1570	327	21	14	14	NUM
admet-1570	327	22	.	.	PUNCT
admet-1570	328	1	comparison	comparison	NOUN
admet-1570	328	2	of	of	ADP
admet-1570	328	3	standard	standard	ADJ
admet-1570	328	4	physiological	physiological	ADJ
admet-1570	328	5	protein	protein	NOUN
admet-1570	328	6	model	model	NOUN
admet-1570	328	7	(	(	PUNCT
admet-1570	328	8	figure	figure	NOUN
admet-1570	328	9	1b	1b	NUM
admet-1570	328	10	)	)	PUNCT
admet-1570	328	11	prediction	prediction	NOUN
admet-1570	328	12	(	(	PUNCT
admet-1570	328	13	line	line	NOUN
admet-1570	328	14	)	)	PUNCT
admet-1570	328	15	following	follow	VERB
admet-1570	328	16	iv	iv	NUM
admet-1570	328	17	bolus	bolus	ADJ
admet-1570	328	18	injection	injection	NOUN
admet-1570	328	19	of	of	ADP
admet-1570	328	20	human	human	ADJ
admet-1570	328	21	purified	purified	ADJ
admet-1570	328	22	placental	placental	ADJ
admet-1570	328	23	alkaline	alkaline	NOUN
admet-1570	328	24	phosphatase	phosphatase	NOUN
admet-1570	328	25	versus	versus	ADP
admet-1570	328	26	experimental	experimental	ADJ
admet-1570	328	27	data	datum	NOUN
admet-1570	328	28	(	(	PUNCT
admet-1570	328	29	solid	solid	ADJ
admet-1570	328	30	circles	circle	NOUN
admet-1570	328	31	)	)	PUNCT
admet-1570	328	32	.	.	PUNCT
admet-1570	329	1	in	in	ADP
admet-1570	329	2	an	an	DET
admet-1570	329	3	older	old	ADJ
admet-1570	329	4	study	study	NOUN
admet-1570	329	5	,	,	PUNCT
admet-1570	329	6	clubb	clubb	PROPN
admet-1570	329	7	et	et	PROPN
admet-1570	329	8	al	al	PROPN
admet-1570	329	9	.	.	PUNCT
admet-1570	330	1	[	[	X
admet-1570	330	2	56	56	NUM
admet-1570	330	3	]	]	PUNCT
admet-1570	330	4	determined	determine	VERB
admet-1570	330	5	the	the	DET
admet-1570	330	6	pk	pk	NOUN
admet-1570	330	7	of	of	ADP
admet-1570	330	8	partially	partially	ADV
admet-1570	330	9	purified	purify	VERB
admet-1570	330	10	human	human	ADJ
admet-1570	330	11	placental	placental	ADJ
admet-1570	330	12	alkaline	alkaline	NOUN
admet-1570	330	13	phosphatase	phosphatase	NOUN
admet-1570	330	14	(	(	PUNCT
admet-1570	330	15	pap	pap	NOUN
admet-1570	330	16	)	)	PUNCT
admet-1570	330	17	following	follow	VERB
admet-1570	330	18	a	a	DET
admet-1570	330	19	bolus	bolus	NOUN
admet-1570	330	20	iv	iv	NOUN
admet-1570	330	21	dose	dose	NOUN
admet-1570	330	22	in	in	ADP
admet-1570	330	23	humans	human	NOUN
admet-1570	330	24	,	,	PUNCT
admet-1570	330	25	using	use	VERB
admet-1570	330	26	the	the	DET
admet-1570	330	27	heat	heat	NOUN
admet-1570	330	28	stability	stability	NOUN
admet-1570	330	29	of	of	ADP
admet-1570	330	30	pap	pap	NOUN
admet-1570	330	31	to	to	PART
admet-1570	330	32	distinguish	distinguish	VERB
admet-1570	330	33	it	it	PRON
admet-1570	330	34	from	from	ADP
admet-1570	330	35	the	the	DET
admet-1570	330	36	endogenous	endogenous	ADJ
admet-1570	330	37	background	background	NOUN
admet-1570	330	38	plasma	plasma	NOUN
admet-1570	330	39	alkaline	alkaline	NOUN
admet-1570	330	40	phosphatases	phosphatase	NOUN
admet-1570	330	41	.	.	PUNCT
admet-1570	331	1	because	because	SCONJ
admet-1570	331	2	of	of	ADP
admet-1570	331	3	the	the	DET
admet-1570	331	4	very	very	ADV
admet-1570	331	5	low	low	ADJ
admet-1570	331	6	glycosylation	glycosylation	NOUN
admet-1570	331	7	of	of	ADP
admet-1570	331	8	pap	pap	NOUN
admet-1570	331	9	,	,	PUNCT
admet-1570	331	10	the	the	DET
admet-1570	331	11	liver	liver	NOUN
admet-1570	331	12	recycling	recycling	NOUN
admet-1570	331	13	should	should	AUX
admet-1570	331	14	be	be	AUX
admet-1570	331	15	negligible	negligible	ADJ
admet-1570	331	16	,	,	PUNCT
admet-1570	331	17	and	and	CCONJ
admet-1570	331	18	we	we	PRON
admet-1570	331	19	attempted	attempt	VERB
admet-1570	331	20	to	to	PART
admet-1570	331	21	fit	fit	VERB
admet-1570	331	22	the	the	DET
admet-1570	331	23	pap	pap	NOUN
admet-1570	331	24	pk	pk	NOUN
admet-1570	331	25	with	with	ADP
admet-1570	331	26	the	the	DET
admet-1570	331	27	standard	standard	ADJ
admet-1570	331	28	protein	protein	NOUN
admet-1570	331	29	model	model	NOUN
admet-1570	331	30	(	(	PUNCT
admet-1570	331	31	figure	figure	NOUN
admet-1570	331	32	1b	1b	NUM
admet-1570	331	33	)	)	PUNCT
admet-1570	331	34	using	use	VERB
admet-1570	331	35	the	the	DET
admet-1570	331	36	monoclonal	monoclonal	NOUN
admet-1570	331	37	antibody	antibody	NOUN
admet-1570	331	38	f1	f1	NOUN
admet-1570	331	39	and	and	CCONJ
admet-1570	331	40	f2	f2	PROPN
admet-1570	331	41	,	,	PUNCT
admet-1570	331	42	and	and	CCONJ
admet-1570	331	43	the	the	DET
admet-1570	331	44	human	human	ADJ
admet-1570	331	45	lymph	lymph	NOUN
admet-1570	331	46	flows	flow	VERB
admet-1570	331	47	l1	l1	PROPN
admet-1570	331	48	and	and	CCONJ
admet-1570	331	49	l2	l2	NOUN
admet-1570	331	50	,	,	PUNCT
admet-1570	331	51	with	with	ADP
admet-1570	331	52	clp	clp	PROPN
admet-1570	331	53	as	as	ADP
admet-1570	331	54	the	the	DET
admet-1570	331	55	only	only	ADJ
admet-1570	331	56	adjustable	adjustable	ADJ
admet-1570	331	57	parameter	parameter	NOUN
admet-1570	331	58	.	.	PUNCT
admet-1570	332	1	as	as	SCONJ
admet-1570	332	2	can	can	AUX
admet-1570	332	3	be	be	AUX
admet-1570	332	4	seen	see	VERB
admet-1570	332	5	in	in	ADP
admet-1570	332	6	figure	figure	NOUN
admet-1570	332	7	14	14	NUM
admet-1570	332	8	,	,	PUNCT
admet-1570	332	9	this	this	DET
admet-1570	332	10	fit	fit	NOUN
admet-1570	332	11	is	be	AUX
admet-1570	332	12	excellent	excellent	ADJ
admet-1570	332	13	,	,	PUNCT
admet-1570	332	14	indicating	indicate	VERB
admet-1570	332	15	that	that	SCONJ
admet-1570	332	16	pap	pap	NOUN
admet-1570	332	17	is	be	AUX
admet-1570	332	18	in	in	ADP
admet-1570	332	19	the	the	DET
admet-1570	332	20	same	same	ADJ
admet-1570	332	21	class	class	NOUN
admet-1570	332	22	as	as	ADP
admet-1570	332	23	all	all	DET
admet-1570	332	24	the	the	DET
admet-1570	332	25	other	other	ADJ
admet-1570	332	26	proteins	protein	NOUN
admet-1570	332	27	in	in	ADP
admet-1570	332	28	table	table	NOUN
admet-1570	332	29	2	2	NUM
admet-1570	332	30	and	and	CCONJ
admet-1570	332	31	that	that	SCONJ
admet-1570	332	32	iap	iap	PROPN
admet-1570	332	33	is	be	AUX
admet-1570	332	34	the	the	DET
admet-1570	332	35	exception	exception	NOUN
admet-1570	332	36	.	.	PUNCT
admet-1570	333	1	clinical	clinical	ADJ
admet-1570	333	2	relevance	relevance	NOUN
admet-1570	333	3	the	the	DET
admet-1570	333	4	primary	primary	ADJ
admet-1570	333	5	aim	aim	NOUN
admet-1570	333	6	of	of	ADP
admet-1570	333	7	this	this	DET
admet-1570	333	8	paper	paper	NOUN
admet-1570	333	9	was	be	AUX
admet-1570	333	10	to	to	PART
admet-1570	333	11	demonstrate	demonstrate	VERB
admet-1570	333	12	that	that	SCONJ
admet-1570	333	13	the	the	DET
admet-1570	333	14	distribution	distribution	NOUN
admet-1570	333	15	and	and	CCONJ
admet-1570	333	16	elimination	elimination	NOUN
admet-1570	333	17	rate	rate	NOUN
admet-1570	333	18	of	of	ADP
admet-1570	333	19	an	an	DET
admet-1570	333	20	infused	infuse	VERB
admet-1570	333	21	bolus	bolus	NOUN
admet-1570	333	22	of	of	ADP
admet-1570	333	23	a	a	DET
admet-1570	333	24	wide	wide	ADJ
admet-1570	333	25	variety	variety	NOUN
admet-1570	333	26	of	of	ADP
admet-1570	333	27	plasma	plasma	NOUN
admet-1570	333	28	proteins	protein	NOUN
admet-1570	333	29	can	can	AUX
admet-1570	333	30	be	be	AUX
admet-1570	333	31	described	describe	VERB
admet-1570	333	32	by	by	ADP
admet-1570	333	33	a	a	DET
admet-1570	333	34	relatively	relatively	ADV
admet-1570	333	35	simple	simple	ADJ
admet-1570	333	36	physiological	physiological	ADJ
admet-1570	333	37	pk	pk	NOUN
admet-1570	333	38	model	model	NOUN
admet-1570	333	39	.	.	PUNCT
admet-1570	334	1	since	since	SCONJ
admet-1570	334	2	all	all	DET
admet-1570	334	3	studies	study	NOUN
admet-1570	334	4	were	be	AUX
admet-1570	334	5	carried	carry	VERB
admet-1570	334	6	out	out	ADP
admet-1570	334	7	in	in	ADP
admet-1570	334	8	healthy	healthy	ADJ
admet-1570	334	9	humans	human	NOUN
admet-1570	334	10	and	and	CCONJ
admet-1570	334	11	animals	animal	NOUN
admet-1570	334	12	,	,	PUNCT
admet-1570	334	13	the	the	DET
admet-1570	334	14	data	datum	NOUN
admet-1570	334	15	provided	provide	VERB
admet-1570	334	16	are	be	AUX
admet-1570	334	17	normal	normal	ADJ
admet-1570	334	18	values	value	NOUN
admet-1570	334	19	.	.	PUNCT
admet-1570	335	1	from	from	ADP
admet-1570	335	2	the	the	DET
admet-1570	335	3	medical	medical	ADJ
admet-1570	335	4	care	care	PROPN
admet-1570	335	5	standpoint	standpoint	NOUN
admet-1570	335	6	,	,	PUNCT
admet-1570	335	7	the	the	DET
admet-1570	335	8	important	important	ADJ
admet-1570	335	9	question	question	NOUN
admet-1570	335	10	is	be	AUX
admet-1570	335	11	to	to	PART
admet-1570	335	12	what	what	DET
admet-1570	335	13	extent	extent	NOUN
admet-1570	335	14	can	can	AUX
admet-1570	335	15	alterations	alteration	NOUN
admet-1570	335	16	in	in	ADP
admet-1570	335	17	these	these	DET
admet-1570	335	18	normal	normal	ADJ
admet-1570	335	19	distribution	distribution	NOUN
admet-1570	335	20	and	and	CCONJ
admet-1570	335	21	elimination	elimination	NOUN
admet-1570	335	22	kinetics	kinetic	NOUN
admet-1570	335	23	produce	produce	VERB
admet-1570	335	24	clinically	clinically	ADV
admet-1570	335	25	relevant	relevant	ADJ
admet-1570	335	26	but	but	CCONJ
admet-1570	335	27	frequently	frequently	ADV
admet-1570	335	28	unrecognized	unrecognize	VERB
admet-1570	335	29	changes	change	NOUN
admet-1570	335	30	in	in	ADP
admet-1570	335	31	plasma	plasma	NOUN
admet-1570	335	32	protein	protein	NOUN
admet-1570	335	33	concentrations	concentration	NOUN
admet-1570	335	34	.	.	PUNCT
admet-1570	336	1	the	the	DET
admet-1570	336	2	answer	answer	NOUN
admet-1570	336	3	to	to	ADP
admet-1570	336	4	this	this	DET
admet-1570	336	5	question	question	NOUN
admet-1570	336	6	,	,	PUNCT
admet-1570	336	7	which	which	PRON
admet-1570	336	8	is	be	AUX
admet-1570	336	9	complicated	complicated	ADJ
admet-1570	336	10	and	and	CCONJ
admet-1570	336	11	different	different	ADJ
admet-1570	336	12	for	for	ADP
admet-1570	336	13	each	each	DET
admet-1570	336	14	protein	protein	NOUN
admet-1570	336	15	,	,	PUNCT
admet-1570	336	16	is	be	AUX
admet-1570	336	17	the	the	DET
admet-1570	336	18	topic	topic	NOUN
admet-1570	336	19	of	of	ADP
admet-1570	336	20	a	a	DET
admet-1570	336	21	subsequent	subsequent	ADJ
admet-1570	336	22	paper	paper	NOUN
admet-1570	336	23	.	.	PUNCT
admet-1570	337	1	however	however	ADV
admet-1570	337	2	,	,	PUNCT
admet-1570	337	3	some	some	DET
admet-1570	337	4	generalities	generality	NOUN
admet-1570	337	5	include	include	VERB
admet-1570	337	6	the	the	DET
admet-1570	337	7	following	following	NOUN
admet-1570	337	8	.	.	PUNCT
admet-1570	338	1	depending	depend	VERB
admet-1570	338	2	on	on	ADP
admet-1570	338	3	the	the	DET
admet-1570	338	4	protein	protein	NOUN
admet-1570	338	5	,	,	PUNCT
admet-1570	338	6	either	either	CCONJ
admet-1570	338	7	increases	increase	NOUN
admet-1570	338	8	or	or	CCONJ
admet-1570	338	9	decreases	decrease	NOUN
admet-1570	338	10	in	in	ADP
admet-1570	338	11	elimination	elimination	NOUN
admet-1570	338	12	rate	rate	NOUN
admet-1570	338	13	could	could	AUX
admet-1570	338	14	cause	cause	VERB
admet-1570	338	15	alterations	alteration	NOUN
admet-1570	338	16	in	in	ADP
admet-1570	338	17	the	the	DET
admet-1570	338	18	plasma	plasma	NOUN
admet-1570	338	19	value	value	NOUN
admet-1570	338	20	that	that	PRON
admet-1570	338	21	could	could	AUX
admet-1570	338	22	be	be	AUX
admet-1570	338	23	of	of	ADP
admet-1570	338	24	clinical	clinical	ADJ
admet-1570	338	25	importance	importance	NOUN
admet-1570	338	26	.	.	PUNCT
admet-1570	339	1	a	a	DET
admet-1570	339	2	clear	clear	ADV
admet-1570	339	3	-	-	PUNCT
admet-1570	339	4	cut	cut	VERB
admet-1570	339	5	example	example	NOUN
admet-1570	339	6	of	of	ADP
admet-1570	339	7	such	such	DET
admet-1570	339	8	an	an	DET
admet-1570	339	9	elimination	elimination	NOUN
admet-1570	339	10	defect	defect	NOUN
admet-1570	339	11	is	be	AUX
admet-1570	339	12	the	the	DET
admet-1570	339	13	formation	formation	NOUN
admet-1570	339	14	of	of	ADP
admet-1570	339	15	globulin	globulin	NOUN
admet-1570	339	16	-	-	PUNCT
admet-1570	339	17	bound	bind	VERB
admet-1570	339	18	enzymes	enzyme	NOUN
admet-1570	339	19	(	(	PUNCT
admet-1570	339	20	“	"	PUNCT
admet-1570	339	21	macro	macro	ADJ
admet-1570	339	22	enzymes	enzyme	NOUN
admet-1570	339	23	”	"	PUNCT
admet-1570	339	24	)	)	PUNCT
admet-1570	339	25	,	,	PUNCT
admet-1570	339	26	an	an	DET
admet-1570	339	27	anomaly	anomaly	NOUN
admet-1570	339	28	reported	report	VERB
admet-1570	339	29	for	for	ADP
admet-1570	339	30	most	most	ADV
admet-1570	339	31	commonly	commonly	ADV
admet-1570	339	32	measured	measure	VERB
admet-1570	339	33	diagnostic	diagnostic	ADJ
admet-1570	339	34	plasma	plasma	NOUN
admet-1570	339	35	enzymes	enzyme	NOUN
admet-1570	339	36	.	.	PUNCT
admet-1570	340	1	the	the	DET
admet-1570	340	2	increased	increase	VERB
admet-1570	340	3	molecular	molecular	ADJ
admet-1570	340	4	size	size	NOUN
admet-1570	340	5	of	of	ADP
admet-1570	340	6	these	these	DET
admet-1570	340	7	macroenzymes	macroenzyme	NOUN
admet-1570	340	8	dramatically	dramatically	ADV
admet-1570	340	9	slows	slow	VERB
admet-1570	340	10	their	their	PRON
admet-1570	340	11	catabolic	catabolic	ADJ
admet-1570	340	12	rate	rate	NOUN
admet-1570	340	13	in	in	ADP
admet-1570	340	14	the	the	DET
admet-1570	340	15	liver	liver	NOUN
admet-1570	340	16	or	or	CCONJ
admet-1570	340	17	glomerular	glomerular	ADJ
admet-1570	340	18	filtration	filtration	NOUN
admet-1570	340	19	rate	rate	NOUN
admet-1570	340	20	(	(	PUNCT
admet-1570	340	21	lipase	lipase	NOUN
admet-1570	340	22	,	,	PUNCT
admet-1570	340	23	amylase	amylase	NOUN
admet-1570	340	24	)	)	PUNCT
admet-1570	340	25	such	such	ADJ
admet-1570	340	26	that	that	DET
admet-1570	340	27	serum	serum	NOUN
admet-1570	340	28	concentration	concentration	NOUN
admet-1570	340	29	rises	rise	VERB
admet-1570	340	30	roughly	roughly	ADV
admet-1570	340	31	in	in	ADP
admet-1570	340	32	proportion	proportion	NOUN
admet-1570	340	33	to	to	ADP
admet-1570	340	34	the	the	DET
admet-1570	340	35	fraction	fraction	NOUN
admet-1570	340	36	of	of	ADP
admet-1570	340	37	enzyme	enzyme	NOUN
admet-1570	340	38	that	that	PRON
admet-1570	340	39	exists	exist	VERB
admet-1570	340	40	in	in	ADP
admet-1570	340	41	the	the	DET
admet-1570	340	42	bound	bind	VERB
admet-1570	340	43	form	form	NOUN
admet-1570	340	44	.	.	PUNCT
admet-1570	341	1	a	a	DET
admet-1570	341	2	disease	disease	NOUN
admet-1570	341	3	of	of	ADP
admet-1570	341	4	the	the	DET
admet-1570	341	5	eliminating	eliminate	VERB
admet-1570	341	6	organ	organ	NOUN
admet-1570	341	7	also	also	ADV
admet-1570	341	8	may	may	AUX
admet-1570	341	9	cause	cause	VERB
admet-1570	341	10	serum	serum	NOUN
admet-1570	341	11	enzyme	enzyme	NOUN
admet-1570	341	12	elevations	elevation	NOUN
admet-1570	341	13	.	.	PUNCT
admet-1570	342	1	the	the	DET
admet-1570	342	2	most	most	ADV
admet-1570	342	3	obvious	obvious	ADJ
admet-1570	342	4	example	example	NOUN
admet-1570	342	5	is	be	AUX
admet-1570	342	6	kidney	kidney	NOUN
admet-1570	342	7	disease	disease	NOUN
admet-1570	342	8	;	;	PUNCT
admet-1570	342	9	up	up	ADP
admet-1570	342	10	to	to	PART
admet-1570	342	11	three	three	NUM
admet-1570	342	12	-	-	ADJ
admet-1570	342	13	fold	fold	ADJ
admet-1570	342	14	elevations	elevation	NOUN
admet-1570	342	15	of	of	ADP
admet-1570	342	16	the	the	DET
admet-1570	342	17	two	two	NUM
admet-1570	342	18	enzymes	enzyme	NOUN
admet-1570	342	19	cleared	clear	VERB
admet-1570	342	20	by	by	ADP
admet-1570	342	21	the	the	DET
admet-1570	342	22	kidney	kidney	NOUN
admet-1570	342	23	,	,	PUNCT
admet-1570	342	24	lipase	lipase	NOUN
admet-1570	342	25	and	and	CCONJ
admet-1570	342	26	amylase	amylase	NOUN
admet-1570	342	27	,	,	PUNCT
admet-1570	342	28	can	can	AUX
admet-1570	342	29	be	be	AUX
admet-1570	342	30	observed	observe	VERB
admet-1570	342	31	in	in	ADP
admet-1570	342	32	renal	renal	ADJ
admet-1570	342	33	insufficiency	insufficiency	NOUN
admet-1570	342	34	[	[	X
admet-1570	342	35	57,58	57,58	NUM
admet-1570	342	36	]	]	PUNCT
admet-1570	342	37	.	.	PUNCT
admet-1570	343	1	similarly	similarly	ADV
admet-1570	343	2	,	,	PUNCT
admet-1570	343	3	hepatic	hepatic	ADJ
admet-1570	343	4	injury	injury	NOUN
admet-1570	343	5	,	,	PUNCT
admet-1570	343	6	e.g.	e.g.	ADV
admet-1570	343	7	,	,	PUNCT
admet-1570	343	8	carbon	carbon	NOUN
admet-1570	343	9	tetrachloride	tetrachloride	NOUN
admet-1570	343	10	-	-	PUNCT
admet-1570	343	11	induced	induce	VERB
admet-1570	343	12	hepatic	hepatic	ADJ
admet-1570	343	13	necrosis	necrosis	NOUN
admet-1570	343	14	in	in	ADP
admet-1570	343	15	rats	rat	NOUN
admet-1570	343	16	,	,	PUNCT
admet-1570	343	17	dramatically	dramatically	ADV
admet-1570	343	18	reduced	reduce	VERB
admet-1570	343	19	the	the	DET
admet-1570	343	20	clearance	clearance	NOUN
admet-1570	343	21	of	of	ADP
admet-1570	343	22	infused	infused	ADJ
admet-1570	343	23	ast	ast	NOUN
admet-1570	344	1	[	[	X
admet-1570	344	2	42	42	NUM
admet-1570	344	3	]	]	PUNCT
admet-1570	344	4	.	.	PUNCT
admet-1570	345	1	thus	thus	ADV
admet-1570	345	2	,	,	PUNCT
admet-1570	345	3	the	the	DET
admet-1570	345	4	elevated	elevated	ADJ
admet-1570	345	5	plasma	plasma	NOUN
admet-1570	345	6	level	level	NOUN
admet-1570	345	7	of	of	ADP
admet-1570	345	8	admet	admet	PROPN
admet-1570	345	9	&	&	CCONJ
admet-1570	345	10	dmpk	dmpk	PROPN
admet-1570	345	11	11(1	11(1	NUM
admet-1570	345	12	)	)	PUNCT
admet-1570	345	13	(	(	PUNCT
admet-1570	345	14	2023	2023	NUM
admet-1570	345	15	)	)	PUNCT
admet-1570	345	16	57	57	NUM
admet-1570	345	17	-	-	SYM
admet-1570	345	18	80	80	NUM
admet-1570	345	19	protein	protein	NOUN
admet-1570	345	20	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	345	21	model	model	NOUN
admet-1570	345	22	doi	doi	NOUN
admet-1570	345	23	:	:	PUNCT
admet-1570	345	24	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	345	25	75	75	NUM
admet-1570	345	26	the	the	DET
admet-1570	345	27	aminotransferases	aminotransferase	NOUN
admet-1570	345	28	characteristic	characteristic	ADJ
admet-1570	345	29	of	of	ADP
admet-1570	345	30	hepatic	hepatic	ADJ
admet-1570	345	31	injury	injury	NOUN
admet-1570	345	32	reflects	reflect	VERB
admet-1570	345	33	,	,	PUNCT
admet-1570	345	34	in	in	ADP
admet-1570	345	35	part	part	NOUN
admet-1570	345	36	,	,	PUNCT
admet-1570	345	37	decreased	decrease	VERB
admet-1570	345	38	elimination	elimination	NOUN
admet-1570	345	39	in	in	ADP
admet-1570	345	40	addition	addition	NOUN
admet-1570	345	41	to	to	ADP
admet-1570	345	42	the	the	DET
admet-1570	345	43	increased	increase	VERB
admet-1570	345	44	release	release	NOUN
admet-1570	345	45	.	.	PUNCT
admet-1570	346	1	another	another	DET
admet-1570	346	2	example	example	NOUN
admet-1570	346	3	of	of	ADP
admet-1570	346	4	the	the	DET
admet-1570	346	5	effect	effect	NOUN
admet-1570	346	6	of	of	ADP
admet-1570	346	7	decreased	decrease	VERB
admet-1570	346	8	liver	liver	NOUN
admet-1570	346	9	clearance	clearance	NOUN
admet-1570	346	10	is	be	AUX
admet-1570	346	11	the	the	DET
admet-1570	346	12	striking	striking	ADJ
admet-1570	346	13	increases	increase	NOUN
admet-1570	346	14	in	in	ADP
admet-1570	346	15	alkaline	alkaline	ADJ
admet-1570	346	16	phosphatase	phosphatase	NOUN
admet-1570	346	17	produced	produce	VERB
admet-1570	346	18	by	by	ADP
admet-1570	346	19	circulating	circulate	VERB
admet-1570	346	20	inhibitors	inhibitor	NOUN
admet-1570	346	21	of	of	ADP
admet-1570	346	22	the	the	DET
admet-1570	346	23	galactose	galactose	ADJ
admet-1570	346	24	(	(	PUNCT
admet-1570	346	25	asialoglycoprotein	asialoglycoprotein	ADJ
admet-1570	346	26	)	)	PUNCT
admet-1570	346	27	receptor	receptor	NOUN
admet-1570	346	28	,	,	PUNCT
admet-1570	346	29	as	as	SCONJ
admet-1570	346	30	postulated	postulate	VERB
admet-1570	346	31	in	in	ADP
admet-1570	346	32	a	a	DET
admet-1570	346	33	recent	recent	ADJ
admet-1570	346	34	paper	paper	NOUN
admet-1570	346	35	[	[	X
admet-1570	346	36	59	59	NUM
admet-1570	346	37	]	]	PUNCT
admet-1570	346	38	.	.	PUNCT
admet-1570	347	1	as	as	SCONJ
admet-1570	347	2	discussed	discuss	VERB
admet-1570	347	3	above	above	ADV
admet-1570	347	4	,	,	PUNCT
admet-1570	347	5	the	the	DET
admet-1570	347	6	degree	degree	NOUN
admet-1570	347	7	of	of	ADP
admet-1570	347	8	sialyation	sialyation	NOUN
admet-1570	347	9	of	of	ADP
admet-1570	347	10	glycoproteins	glycoprotein	NOUN
admet-1570	347	11	has	have	VERB
admet-1570	347	12	a	a	DET
admet-1570	347	13	dramatic	dramatic	ADJ
admet-1570	347	14	effect	effect	NOUN
admet-1570	347	15	on	on	ADP
admet-1570	347	16	their	their	PRON
admet-1570	347	17	elimination	elimination	NOUN
admet-1570	347	18	rates	rate	NOUN
admet-1570	347	19	.	.	PUNCT
admet-1570	348	1	since	since	SCONJ
admet-1570	348	2	the	the	DET
admet-1570	348	3	desialylation	desialylation	NOUN
admet-1570	348	4	of	of	ADP
admet-1570	348	5	circulating	circulate	VERB
admet-1570	348	6	proteins	protein	NOUN
admet-1570	348	7	is	be	AUX
admet-1570	348	8	enhanced	enhance	VERB
admet-1570	348	9	in	in	ADP
admet-1570	348	10	various	various	ADJ
admet-1570	348	11	disease	disease	NOUN
admet-1570	348	12	states	state	NOUN
admet-1570	348	13	,	,	PUNCT
admet-1570	348	14	e.g.	e.g.	ADV
admet-1570	348	15	,	,	PUNCT
admet-1570	348	16	hyperthyroidism	hyperthyroidism	NOUN
admet-1570	348	17	[	[	X
admet-1570	348	18	60	60	NUM
admet-1570	348	19	]	]	PUNCT
admet-1570	348	20	,	,	PUNCT
admet-1570	348	21	this	this	DET
admet-1570	348	22	activity	activity	NOUN
admet-1570	348	23	would	would	AUX
admet-1570	348	24	be	be	AUX
admet-1570	348	25	expected	expect	VERB
admet-1570	348	26	to	to	PART
admet-1570	348	27	have	have	VERB
admet-1570	348	28	a	a	DET
admet-1570	348	29	major	major	ADJ
admet-1570	348	30	effect	effect	NOUN
admet-1570	348	31	on	on	ADP
admet-1570	348	32	the	the	DET
admet-1570	348	33	serum	serum	NOUN
admet-1570	348	34	glycoprotein	glycoprotein	NOUN
admet-1570	348	35	protein	protein	NOUN
admet-1570	348	36	concentration	concentration	NOUN
admet-1570	348	37	.	.	PUNCT
admet-1570	349	1	hypoalbuminemia	hypoalbuminemia	PROPN
admet-1570	349	2	is	be	AUX
admet-1570	349	3	a	a	DET
admet-1570	349	4	common	common	ADJ
admet-1570	349	5	finding	finding	NOUN
admet-1570	349	6	in	in	ADP
admet-1570	349	7	a	a	DET
admet-1570	349	8	wide	wide	ADJ
admet-1570	349	9	variety	variety	NOUN
admet-1570	349	10	of	of	ADP
admet-1570	349	11	disease	disease	NOUN
admet-1570	349	12	states	state	NOUN
admet-1570	349	13	,	,	PUNCT
admet-1570	349	14	and	and	CCONJ
admet-1570	349	15	this	this	DET
admet-1570	349	16	finding	finding	NOUN
admet-1570	349	17	is	be	AUX
admet-1570	349	18	associated	associate	VERB
admet-1570	349	19	with	with	ADP
admet-1570	349	20	a	a	DET
admet-1570	349	21	poor	poor	ADJ
admet-1570	349	22	prognosis	prognosis	NOUN
admet-1570	349	23	[	[	X
admet-1570	349	24	25	25	NUM
admet-1570	349	25	]	]	PUNCT
admet-1570	349	26	.	.	PUNCT
admet-1570	350	1	while	while	SCONJ
admet-1570	350	2	clinicians	clinician	NOUN
admet-1570	350	3	commonly	commonly	ADV
admet-1570	350	4	attribute	attribute	VERB
admet-1570	350	5	these	these	DET
admet-1570	350	6	low	low	ADJ
admet-1570	350	7	serum	serum	NOUN
admet-1570	350	8	albumin	albumin	ADJ
admet-1570	350	9	values	value	NOUN
admet-1570	350	10	to	to	PART
admet-1570	350	11	decreased	decrease	VERB
admet-1570	350	12	synthesis	synthesis	NOUN
admet-1570	350	13	(	(	PUNCT
admet-1570	350	14	“	"	PUNCT
admet-1570	350	15	malnutrition	malnutrition	NOUN
admet-1570	350	16	”	"	PUNCT
admet-1570	350	17	,	,	PUNCT
admet-1570	350	18	etc	etc	X
admet-1570	350	19	.	.	X
admet-1570	350	20	)	)	PUNCT
admet-1570	350	21	,	,	PUNCT
admet-1570	350	22	multiple	multiple	ADJ
admet-1570	350	23	studies	study	NOUN
admet-1570	350	24	have	have	AUX
admet-1570	350	25	shown	show	VERB
admet-1570	350	26	that	that	SCONJ
admet-1570	350	27	,	,	PUNCT
admet-1570	350	28	with	with	ADP
admet-1570	350	29	the	the	DET
admet-1570	350	30	exception	exception	NOUN
admet-1570	350	31	of	of	ADP
admet-1570	350	32	cirrhosis	cirrhosis	NOUN
admet-1570	350	33	and	and	CCONJ
admet-1570	350	34	kwashiorkor	kwashiorkor	NOUN
admet-1570	350	35	,	,	PUNCT
admet-1570	350	36	it	it	PRON
admet-1570	350	37	is	be	AUX
admet-1570	350	38	actually	actually	ADV
admet-1570	350	39	increased	increase	VERB
admet-1570	350	40	elimination	elimination	NOUN
admet-1570	350	41	that	that	PRON
admet-1570	350	42	is	be	AUX
admet-1570	350	43	the	the	DET
admet-1570	350	44	major	major	ADJ
admet-1570	350	45	cause	cause	NOUN
admet-1570	350	46	of	of	ADP
admet-1570	350	47	hypoalbuminemia	hypoalbuminemia	NOUN
admet-1570	351	1	[	[	X
admet-1570	351	2	25	25	NUM
admet-1570	351	3	]	]	PUNCT
admet-1570	351	4	.	.	PUNCT
admet-1570	352	1	this	this	DET
admet-1570	352	2	enhanced	enhance	VERB
admet-1570	352	3	elimination	elimination	NOUN
admet-1570	352	4	may	may	AUX
admet-1570	352	5	be	be	AUX
admet-1570	352	6	due	due	ADJ
admet-1570	352	7	to	to	ADP
admet-1570	352	8	increased	increase	VERB
admet-1570	352	9	activity	activity	NOUN
admet-1570	352	10	of	of	ADP
admet-1570	352	11	the	the	DET
admet-1570	352	12	normally	normally	ADV
admet-1570	352	13	catabolizing	catabolize	VERB
admet-1570	352	14	organs	organ	NOUN
admet-1570	352	15	or	or	CCONJ
admet-1570	352	16	an	an	DET
admet-1570	352	17	unusual	unusual	ADJ
admet-1570	352	18	rate	rate	NOUN
admet-1570	352	19	of	of	ADP
admet-1570	352	20	loss	loss	NOUN
admet-1570	352	21	of	of	ADP
admet-1570	352	22	albumin	albumin	NOUN
admet-1570	352	23	into	into	ADP
admet-1570	352	24	the	the	DET
admet-1570	352	25	gut	gut	NOUN
admet-1570	352	26	lumen	luman	NOUN
admet-1570	352	27	or	or	CCONJ
admet-1570	352	28	urine	urine	NOUN
admet-1570	352	29	[	[	X
admet-1570	352	30	61	61	NUM
admet-1570	352	31	]	]	PUNCT
admet-1570	352	32	.	.	PUNCT
admet-1570	353	1	the	the	DET
admet-1570	353	2	development	development	NOUN
admet-1570	353	3	of	of	ADP
admet-1570	353	4	igg	igg	PROPN
admet-1570	353	5	monoclonal	monoclonal	NOUN
admet-1570	353	6	antibody	antibody	NOUN
admet-1570	353	7	therapies	therapy	NOUN
admet-1570	353	8	has	have	AUX
admet-1570	353	9	stimulated	stimulate	VERB
admet-1570	353	10	interest	interest	NOUN
admet-1570	353	11	in	in	ADP
admet-1570	353	12	the	the	DET
admet-1570	353	13	elimination	elimination	NOUN
admet-1570	353	14	rate	rate	NOUN
admet-1570	353	15	of	of	ADP
admet-1570	353	16	these	these	DET
admet-1570	353	17	compounds	compound	NOUN
admet-1570	353	18	[	[	X
admet-1570	353	19	28	28	NUM
admet-1570	353	20	-	-	SYM
admet-1570	353	21	30	30	NUM
admet-1570	353	22	]	]	PUNCT
admet-1570	353	23	.	.	PUNCT
admet-1570	354	1	the	the	DET
admet-1570	354	2	frequency	frequency	NOUN
admet-1570	354	3	of	of	ADP
admet-1570	354	4	igg	igg	PROPN
admet-1570	354	5	dosing	dosing	NOUN
admet-1570	354	6	required	require	VERB
admet-1570	354	7	to	to	PART
admet-1570	354	8	maintain	maintain	VERB
admet-1570	354	9	a	a	DET
admet-1570	354	10	therapeutic	therapeutic	ADJ
admet-1570	354	11	plasma	plasma	NOUN
admet-1570	354	12	concentration	concentration	NOUN
admet-1570	354	13	as	as	ADP
admet-1570	354	14	a	a	DET
admet-1570	354	15	function	function	NOUN
admet-1570	354	16	of	of	ADP
admet-1570	354	17	elimination	elimination	NOUN
admet-1570	354	18	rate	rate	NOUN
admet-1570	354	19	and	and	CCONJ
admet-1570	354	20	trough	trough	NOUN
admet-1570	354	21	concentration	concentration	NOUN
admet-1570	354	22	measurements	measurement	NOUN
admet-1570	354	23	have	have	AUX
admet-1570	354	24	become	become	VERB
admet-1570	354	25	routine	routine	ADJ
admet-1570	354	26	clinical	clinical	ADJ
admet-1570	354	27	assays	assay	NOUN
admet-1570	354	28	for	for	ADP
admet-1570	354	29	some	some	DET
admet-1570	354	30	monoclonal	monoclonal	NOUN
admet-1570	354	31	antibodies	antibodie	VERB
admet-1570	354	32	.	.	PUNCT
admet-1570	355	1	alteration	alteration	NOUN
admet-1570	355	2	of	of	ADP
admet-1570	355	3	the	the	DET
admet-1570	355	4	molecular	molecular	ADJ
admet-1570	355	5	structure	structure	NOUN
admet-1570	355	6	of	of	ADP
admet-1570	355	7	selected	select	VERB
admet-1570	355	8	monoclonal	monoclonal	NOUN
admet-1570	355	9	antibodies	antibody	NOUN
admet-1570	355	10	has	have	AUX
admet-1570	355	11	been	be	AUX
admet-1570	355	12	used	use	VERB
admet-1570	355	13	to	to	PART
admet-1570	355	14	reduce	reduce	VERB
admet-1570	355	15	the	the	DET
admet-1570	355	16	elimination	elimination	NOUN
admet-1570	355	17	rate	rate	NOUN
admet-1570	355	18	and	and	CCONJ
admet-1570	355	19	hence	hence	ADV
admet-1570	355	20	prolong	prolong	ADJ
admet-1570	355	21	effectiveness	effectiveness	NOUN
admet-1570	355	22	[	[	X
admet-1570	355	23	62	62	NUM
admet-1570	355	24	]	]	PUNCT
admet-1570	355	25	.	.	PUNCT
admet-1570	356	1	much	much	ADJ
admet-1570	356	2	of	of	ADP
admet-1570	356	3	the	the	DET
admet-1570	356	4	emphasis	emphasis	NOUN
admet-1570	356	5	in	in	ADP
admet-1570	356	6	this	this	DET
admet-1570	356	7	pk	pk	NOUN
admet-1570	356	8	modeling	modeling	NOUN
admet-1570	356	9	discussion	discussion	NOUN
admet-1570	356	10	was	be	AUX
admet-1570	356	11	focused	focus	VERB
admet-1570	356	12	on	on	ADP
admet-1570	356	13	the	the	DET
admet-1570	356	14	kinetics	kinetic	NOUN
admet-1570	356	15	of	of	ADP
admet-1570	356	16	exchange	exchange	NOUN
admet-1570	356	17	and	and	CCONJ
admet-1570	356	18	distribution	distribution	NOUN
admet-1570	356	19	with	with	ADP
admet-1570	356	20	the	the	DET
admet-1570	356	21	extravascular	extravascular	ADJ
admet-1570	356	22	space	space	NOUN
admet-1570	356	23	.	.	PUNCT
admet-1570	357	1	however	however	ADV
admet-1570	357	2	,	,	PUNCT
admet-1570	357	3	at	at	ADP
admet-1570	357	4	homeostasis	homeostasis	NOUN
admet-1570	357	5	,	,	PUNCT
admet-1570	357	6	the	the	DET
admet-1570	357	7	rate	rate	NOUN
admet-1570	357	8	of	of	ADP
admet-1570	357	9	delivery	delivery	NOUN
admet-1570	357	10	to	to	PART
admet-1570	357	11	and	and	CCONJ
admet-1570	357	12	return	return	VERB
admet-1570	357	13	from	from	ADP
admet-1570	357	14	the	the	DET
admet-1570	357	15	extravascular	extravascular	ADJ
admet-1570	357	16	pools	pool	NOUN
admet-1570	357	17	are	be	AUX
admet-1570	357	18	equal	equal	ADJ
admet-1570	357	19	,	,	PUNCT
admet-1570	357	20	hence	hence	ADV
admet-1570	357	21	the	the	DET
admet-1570	357	22	plasma	plasma	NOUN
admet-1570	357	23	concentration	concentration	NOUN
admet-1570	357	24	is	be	AUX
admet-1570	357	25	independent	independent	ADJ
admet-1570	357	26	of	of	ADP
admet-1570	357	27	the	the	DET
admet-1570	357	28	rate	rate	NOUN
admet-1570	357	29	of	of	ADP
admet-1570	357	30	distribution	distribution	NOUN
admet-1570	357	31	and	and	CCONJ
admet-1570	357	32	depends	depend	VERB
admet-1570	357	33	only	only	ADV
admet-1570	357	34	on	on	ADP
admet-1570	357	35	the	the	DET
admet-1570	357	36	rates	rate	NOUN
admet-1570	357	37	of	of	ADP
admet-1570	357	38	synthesis	synthesis	NOUN
admet-1570	357	39	and	and	CCONJ
admet-1570	357	40	elimination	elimination	NOUN
admet-1570	357	41	.	.	PUNCT
admet-1570	358	1	the	the	DET
admet-1570	358	2	rates	rate	NOUN
admet-1570	358	3	of	of	ADP
admet-1570	358	4	exchange	exchange	NOUN
admet-1570	358	5	with	with	ADP
admet-1570	358	6	the	the	DET
admet-1570	358	7	extravascular	extravascular	ADJ
admet-1570	358	8	pools	pool	NOUN
admet-1570	358	9	as	as	ADV
admet-1570	358	10	well	well	ADV
admet-1570	358	11	as	as	ADP
admet-1570	358	12	the	the	DET
admet-1570	358	13	size	size	NOUN
admet-1570	358	14	of	of	ADP
admet-1570	358	15	the	the	DET
admet-1570	358	16	pool	pool	NOUN
admet-1570	358	17	,	,	PUNCT
admet-1570	358	18	do	do	AUX
admet-1570	358	19	influence	influence	VERB
admet-1570	358	20	non	non	ADJ
admet-1570	358	21	-	-	ADJ
admet-1570	358	22	steady	steady	ADJ
admet-1570	358	23	state	state	NOUN
admet-1570	358	24	plasma	plasma	NOUN
admet-1570	358	25	concentrations	concentration	NOUN
admet-1570	358	26	,	,	PUNCT
admet-1570	358	27	such	such	ADJ
admet-1570	358	28	as	as	ADP
admet-1570	358	29	the	the	DET
admet-1570	358	30	timing	timing	NOUN
admet-1570	358	31	and	and	CCONJ
admet-1570	358	32	magnitude	magnitude	NOUN
admet-1570	358	33	of	of	ADP
admet-1570	358	34	peak	peak	NOUN
admet-1570	358	35	plasma	plasma	NOUN
admet-1570	358	36	concentrations	concentration	NOUN
admet-1570	358	37	following	follow	VERB
admet-1570	358	38	periodically	periodically	ADV
admet-1570	358	39	administered	administer	VERB
admet-1570	358	40	monoclonal	monoclonal	NOUN
admet-1570	358	41	antibodies	antibody	NOUN
admet-1570	358	42	or	or	CCONJ
admet-1570	358	43	the	the	DET
admet-1570	358	44	rate	rate	NOUN
admet-1570	358	45	of	of	ADP
admet-1570	358	46	rise	rise	NOUN
admet-1570	358	47	and	and	CCONJ
admet-1570	358	48	fall	fall	NOUN
admet-1570	358	49	of	of	ADP
admet-1570	358	50	liver	liver	NOUN
admet-1570	358	51	enzymes	enzyme	NOUN
admet-1570	358	52	after	after	ADP
admet-1570	358	53	a	a	DET
admet-1570	358	54	brief	brief	ADJ
admet-1570	358	55	insult	insult	NOUN
admet-1570	358	56	.	.	PUNCT
admet-1570	359	1	the	the	DET
admet-1570	359	2	appreciable	appreciable	ADJ
admet-1570	359	3	extravascular	extravascular	ADJ
admet-1570	359	4	distribution	distribution	NOUN
admet-1570	359	5	of	of	ADP
admet-1570	359	6	proteins	protein	NOUN
admet-1570	359	7	(	(	PUNCT
admet-1570	359	8	e.g.	e.g.	ADV
admet-1570	359	9	,	,	PUNCT
admet-1570	359	10	1.24	1.24	NUM
admet-1570	359	11	times	time	NOUN
admet-1570	359	12	the	the	DET
admet-1570	359	13	plasma	plasma	NOUN
admet-1570	359	14	volume	volume	NOUN
admet-1570	359	15	for	for	ADP
admet-1570	359	16	albumin	albumin	NOUN
admet-1570	359	17	at	at	ADP
admet-1570	359	18	homeostasis	homeostasis	NOUN
admet-1570	359	19	)	)	PUNCT
admet-1570	359	20	buffers	buffer	NOUN
admet-1570	359	21	the	the	DET
admet-1570	359	22	rate	rate	NOUN
admet-1570	359	23	of	of	ADP
admet-1570	359	24	change	change	NOUN
admet-1570	359	25	in	in	ADP
admet-1570	359	26	plasma	plasma	NOUN
admet-1570	359	27	protein	protein	NOUN
admet-1570	359	28	in	in	ADP
admet-1570	359	29	the	the	DET
admet-1570	359	30	non	non	ADJ
admet-1570	359	31	-	-	ADJ
admet-1570	359	32	steady	steady	ADJ
admet-1570	359	33	state	state	NOUN
admet-1570	359	34	,	,	PUNCT
admet-1570	359	35	hence	hence	ADV
admet-1570	359	36	,	,	PUNCT
admet-1570	359	37	influencing	influence	VERB
admet-1570	359	38	clinically	clinically	ADV
admet-1570	359	39	important	important	ADJ
admet-1570	359	40	values	value	NOUN
admet-1570	359	41	such	such	ADJ
admet-1570	359	42	as	as	ADP
admet-1570	359	43	the	the	DET
admet-1570	359	44	apparent	apparent	ADJ
admet-1570	359	45	half	half	ADJ
admet-1570	359	46	-	-	PUNCT
admet-1570	359	47	time	time	NOUN
admet-1570	359	48	of	of	ADP
admet-1570	359	49	various	various	ADJ
admet-1570	359	50	proteins	protein	NOUN
admet-1570	359	51	.	.	PUNCT
admet-1570	360	1	summary	summary	VERB
admet-1570	360	2	the	the	DET
admet-1570	360	3	three	three	NUM
admet-1570	360	4	-	-	PUNCT
admet-1570	360	5	compartment	compartment	NOUN
admet-1570	360	6	model	model	NOUN
admet-1570	360	7	shown	show	VERB
admet-1570	360	8	in	in	ADP
admet-1570	360	9	figure	figure	NOUN
admet-1570	360	10	1a	1a	PROPN
admet-1570	360	11	is	be	AUX
admet-1570	360	12	the	the	DET
admet-1570	360	13	standard	standard	ADJ
admet-1570	360	14	3	3	NUM
admet-1570	360	15	-	-	PUNCT
admet-1570	360	16	exponential	exponential	ADJ
admet-1570	360	17	,	,	PUNCT
admet-1570	360	18	6	6	NUM
admet-1570	360	19	-	-	PUNCT
admet-1570	360	20	parameter	parameter	NOUN
admet-1570	360	21	description	description	NOUN
admet-1570	360	22	routinely	routinely	ADV
admet-1570	360	23	used	use	VERB
admet-1570	360	24	to	to	PART
admet-1570	360	25	describe	describe	VERB
admet-1570	360	26	plasma	plasma	NOUN
admet-1570	360	27	pk	pk	NOUN
admet-1570	360	28	.	.	PUNCT
admet-1570	361	1	we	we	PRON
admet-1570	361	2	have	have	AUX
admet-1570	361	3	interpreted	interpret	VERB
admet-1570	361	4	this	this	DET
admet-1570	361	5	model	model	NOUN
admet-1570	361	6	in	in	ADP
admet-1570	361	7	terms	term	NOUN
admet-1570	361	8	of	of	ADP
admet-1570	361	9	a	a	DET
admet-1570	361	10	lumped	lump	VERB
admet-1570	361	11	physiological	physiological	ADJ
admet-1570	361	12	model	model	NOUN
admet-1570	361	13	(	(	PUNCT
admet-1570	361	14	figure	figure	NOUN
admet-1570	361	15	1b	1b	NUM
admet-1570	361	16	)	)	PUNCT
admet-1570	361	17	in	in	ADP
admet-1570	361	18	which	which	PRON
admet-1570	361	19	the	the	DET
admet-1570	361	20	exchange	exchange	NOUN
admet-1570	361	21	between	between	ADP
admet-1570	361	22	the	the	DET
admet-1570	361	23	blood	blood	NOUN
admet-1570	361	24	and	and	CCONJ
admet-1570	361	25	tissue	tissue	NOUN
admet-1570	361	26	is	be	AUX
admet-1570	361	27	purely	purely	ADV
admet-1570	361	28	convective	convective	ADJ
admet-1570	361	29	,	,	PUNCT
admet-1570	361	30	dependent	dependent	ADJ
admet-1570	361	31	on	on	ADP
admet-1570	361	32	the	the	DET
admet-1570	361	33	lymph	lymph	NOUN
admet-1570	361	34	flows	flow	VERB
admet-1570	361	35	l1	l1	PROPN
admet-1570	361	36	and	and	CCONJ
admet-1570	361	37	l2	l2	NOUN
admet-1570	361	38	and	and	CCONJ
admet-1570	361	39	filtration	filtration	NOUN
admet-1570	361	40	coefficients	coefficient	NOUN
admet-1570	361	41	f1	f1	NOUN
admet-1570	361	42	and	and	CCONJ
admet-1570	361	43	f2	f2	PROPN
admet-1570	361	44	.	.	PUNCT
admet-1570	362	1	for	for	ADP
admet-1570	362	2	a	a	DET
admet-1570	362	3	given	give	VERB
admet-1570	362	4	species	specie	NOUN
admet-1570	362	5	,	,	PUNCT
admet-1570	362	6	we	we	PRON
admet-1570	362	7	first	first	ADV
admet-1570	362	8	estimate	estimate	VERB
admet-1570	362	9	the	the	DET
admet-1570	362	10	four	four	NUM
admet-1570	362	11	adjustable	adjustable	ADJ
admet-1570	362	12	model	model	NOUN
admet-1570	362	13	parameters	parameter	NOUN
admet-1570	362	14	l1	l1	PROPN
admet-1570	362	15	,	,	PUNCT
admet-1570	362	16	l2	l2	NOUN
admet-1570	362	17	and	and	CCONJ
admet-1570	362	18	tissue	tissue	NOUN
admet-1570	362	19	volumes	volume	NOUN
admet-1570	362	20	v1	v1	VERB
admet-1570	362	21	and	and	CCONJ
admet-1570	362	22	v2	v2	NOUN
admet-1570	362	23	.	.	PUNCT
admet-1570	363	1	assuming	assume	VERB
admet-1570	363	2	that	that	SCONJ
admet-1570	363	3	these	these	DET
admet-1570	363	4	parameters	parameter	NOUN
admet-1570	363	5	are	be	AUX
admet-1570	363	6	the	the	DET
admet-1570	363	7	same	same	ADJ
admet-1570	363	8	for	for	ADP
admet-1570	363	9	any	any	DET
admet-1570	363	10	protein	protein	NOUN
admet-1570	363	11	in	in	ADP
admet-1570	363	12	that	that	DET
admet-1570	363	13	species	specie	NOUN
admet-1570	363	14	implies	imply	VERB
admet-1570	363	15	that	that	SCONJ
admet-1570	363	16	each	each	DET
admet-1570	363	17	protein	protein	NOUN
admet-1570	363	18	is	be	AUX
admet-1570	363	19	uniquely	uniquely	ADV
admet-1570	363	20	characterized	characterize	VERB
admet-1570	363	21	by	by	ADP
admet-1570	363	22	only	only	ADV
admet-1570	363	23	3	3	NUM
admet-1570	363	24	parameters	parameter	NOUN
admet-1570	363	25	:	:	PUNCT
admet-1570	363	26	the	the	DET
admet-1570	363	27	clearance	clearance	NOUN
admet-1570	363	28	clp	clp	NOUN
admet-1570	363	29	,	,	PUNCT
admet-1570	363	30	and	and	CCONJ
admet-1570	363	31	f1	f1	NOUN
admet-1570	363	32	and	and	CCONJ
admet-1570	363	33	f2	f2	PROPN
admet-1570	363	34	.	.	PUNCT
admet-1570	364	1	imposing	impose	VERB
admet-1570	364	2	the	the	DET
admet-1570	364	3	additional	additional	ADJ
admet-1570	364	4	constraint	constraint	NOUN
admet-1570	364	5	(	(	PUNCT
admet-1570	364	6	satisfied	satisfy	VERB
admet-1570	364	7	by	by	ADP
admet-1570	364	8	the	the	DET
admet-1570	364	9	results	result	NOUN
admet-1570	364	10	in	in	ADP
admet-1570	364	11	table	table	NOUN
admet-1570	364	12	2	2	NUM
admet-1570	364	13	)	)	PUNCT
admet-1570	364	14	that	that	DET
admet-1570	364	15	f1	f1	PROPN
admet-1570	364	16	≈	≈	PROPN
admet-1570	364	17	f2	f2	PROPN
admet-1570	364	18	,	,	PUNCT
admet-1570	364	19	effectively	effectively	ADV
admet-1570	364	20	reduces	reduce	VERB
admet-1570	364	21	it	it	PRON
admet-1570	364	22	to	to	ADP
admet-1570	364	23	two	two	NUM
admet-1570	364	24	adjustable	adjustable	ADJ
admet-1570	364	25	parameters	parameter	NOUN
admet-1570	364	26	.	.	PUNCT
admet-1570	365	1	interpreting	interpret	VERB
admet-1570	365	2	these	these	DET
admet-1570	365	3	parameters	parameter	NOUN
admet-1570	365	4	in	in	ADP
admet-1570	365	5	terms	term	NOUN
admet-1570	365	6	of	of	ADP
admet-1570	365	7	the	the	DET
admet-1570	365	8	physiological	physiological	ADJ
admet-1570	365	9	convection	convection	NOUN
admet-1570	365	10	model	model	NOUN
admet-1570	365	11	(	(	PUNCT
admet-1570	365	12	figure	figure	NOUN
admet-1570	365	13	1b	1b	NUM
admet-1570	365	14	)	)	PUNCT
admet-1570	365	15	has	have	VERB
admet-1570	365	16	two	two	NUM
admet-1570	365	17	important	important	ADJ
admet-1570	365	18	advantages	advantage	NOUN
admet-1570	365	19	.	.	PUNCT
admet-1570	366	1	first	first	ADV
admet-1570	366	2	,	,	PUNCT
admet-1570	366	3	as	as	SCONJ
admet-1570	366	4	discussed	discuss	VERB
admet-1570	366	5	above	above	ADV
admet-1570	366	6	,	,	PUNCT
admet-1570	366	7	it	it	PRON
admet-1570	366	8	puts	put	VERB
admet-1570	366	9	strong	strong	ADJ
admet-1570	366	10	bounds	bound	NOUN
admet-1570	366	11	on	on	ADP
admet-1570	366	12	the	the	DET
admet-1570	366	13	values	value	NOUN
admet-1570	366	14	of	of	ADP
admet-1570	366	15	the	the	DET
admet-1570	366	16	parameters	parameter	NOUN
admet-1570	366	17	.	.	PUNCT
admet-1570	367	1	for	for	ADP
admet-1570	367	2	example	example	NOUN
admet-1570	367	3	,	,	PUNCT
admet-1570	367	4	the	the	DET
admet-1570	367	5	human	human	ADJ
admet-1570	367	6	pk	pk	NOUN
admet-1570	367	7	of	of	ADP
admet-1570	367	8	an	an	DET
admet-1570	367	9	arbitrary	arbitrary	ADJ
admet-1570	367	10	protein	protein	NOUN
admet-1570	367	11	should	should	AUX
admet-1570	367	12	have	have	VERB
admet-1570	367	13	the	the	DET
admet-1570	367	14	same	same	ADJ
admet-1570	367	15	values	value	NOUN
admet-1570	367	16	of	of	ADP
admet-1570	367	17	v1	v1	NOUN
admet-1570	367	18	,	,	PUNCT
admet-1570	367	19	v2	v2	PROPN
admet-1570	367	20	,	,	PUNCT
admet-1570	367	21	l1	l1	PROPN
admet-1570	367	22	and	and	CCONJ
admet-1570	367	23	l2	l2	NOUN
admet-1570	367	24	determined	determine	VERB
admet-1570	367	25	in	in	ADP
admet-1570	367	26	table	table	NOUN
admet-1570	367	27	2	2	NUM
admet-1570	367	28	and	and	CCONJ
admet-1570	367	29	since	since	SCONJ
admet-1570	367	30	f1	f1	NOUN
admet-1570	367	31	and	and	CCONJ
admet-1570	367	32	f2	f2	PROPN
admet-1570	367	33	can	can	AUX
admet-1570	367	34	be	be	AUX
admet-1570	367	35	estimated	estimate	VERB
admet-1570	367	36	from	from	ADP
admet-1570	367	37	the	the	DET
admet-1570	367	38	molecular	molecular	ADJ
admet-1570	367	39	weight	weight	NOUN
admet-1570	367	40	,	,	PUNCT
admet-1570	367	41	there	there	PRON
admet-1570	367	42	is	be	VERB
admet-1570	367	43	actually	actually	ADV
admet-1570	367	44	only	only	ADV
admet-1570	367	45	one	one	NUM
admet-1570	367	46	primary	primary	ADJ
admet-1570	367	47	adjustable	adjustable	ADJ
admet-1570	367	48	parameter	parameter	NOUN
admet-1570	367	49	,	,	PUNCT
admet-1570	367	50	the	the	DET
admet-1570	367	51	plasma	plasma	NOUN
admet-1570	367	52	clearance	clearance	NOUN
admet-1570	367	53	(	(	PUNCT
admet-1570	367	54	clp	clp	NOUN
admet-1570	367	55	)	)	PUNCT
admet-1570	367	56	,	,	PUNCT
admet-1570	367	57	in	in	ADP
admet-1570	367	58	place	place	NOUN
admet-1570	367	59	of	of	ADP
admet-1570	367	60	the	the	DET
admet-1570	367	61	5	5	NUM
admet-1570	367	62	parameters	parameter	NOUN
admet-1570	367	63	of	of	ADP
admet-1570	367	64	the	the	DET
admet-1570	367	65	compartmental	compartmental	ADJ
admet-1570	367	66	model	model	NOUN
admet-1570	367	67	(	(	PUNCT
admet-1570	367	68	figure	figure	NOUN
admet-1570	367	69	1a	1a	NOUN
admet-1570	367	70	,	,	PUNCT
admet-1570	367	71	eq	eq	NOUN
admet-1570	367	72	.	.	PROPN
admet-1570	367	73	1	1	NUM
admet-1570	367	74	)	)	PUNCT
admet-1570	367	75	.	.	PUNCT
admet-1570	368	1	secondly	secondly	ADV
admet-1570	368	2	,	,	PUNCT
admet-1570	368	3	it	it	PRON
admet-1570	368	4	allows	allow	VERB
admet-1570	368	5	one	one	PRON
admet-1570	368	6	to	to	PART
admet-1570	368	7	use	use	VERB
admet-1570	368	8	the	the	DET
admet-1570	368	9	plasma	plasma	NOUN
admet-1570	368	10	pk	pk	NOUN
admet-1570	368	11	to	to	PART
admet-1570	368	12	predict	predict	VERB
admet-1570	368	13	the	the	DET
admet-1570	368	14	tissue	tissue	NOUN
admet-1570	368	15	and	and	CCONJ
admet-1570	368	16	lymph	lymph	NOUN
admet-1570	368	17	protein	protein	NOUN
admet-1570	369	1	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	369	2	d.g	d.g	PROPN
admet-1570	369	3	.	.	PROPN
admet-1570	369	4	levitt	levitt	PROPN
admet-1570	369	5	and	and	CCONJ
admet-1570	369	6	m.d	m.d	PROPN
admet-1570	369	7	.	.	PROPN
admet-1570	369	8	levitt	levitt	PROPN
admet-1570	369	9	admet	admet	PROPN
admet-1570	369	10	&	&	CCONJ
admet-1570	369	11	dmpk	dmpk	PROPN
admet-1570	369	12	11(1	11(1	NUM
admet-1570	369	13	)	)	PUNCT
admet-1570	369	14	(	(	PUNCT
admet-1570	369	15	2023	2023	NUM
admet-1570	369	16	)	)	PUNCT
admet-1570	369	17	57	57	NUM
admet-1570	369	18	-	-	SYM
admet-1570	369	19	80	80	NUM
admet-1570	369	20	76	76	NUM
admet-1570	369	21	kinetics	kinetic	NOUN
admet-1570	369	22	:	:	PUNCT
admet-1570	369	23	1	1	X
admet-1570	369	24	)	)	PUNCT
admet-1570	369	25	the	the	DET
admet-1570	369	26	total	total	ADJ
admet-1570	369	27	lymph	lymph	NOUN
admet-1570	369	28	flow	flow	NOUN
admet-1570	369	29	(	(	PUNCT
admet-1570	369	30	eq	eq	NOUN
admet-1570	369	31	.	.	PROPN
admet-1570	369	32	4	4	NUM
admet-1570	369	33	)	)	PUNCT
admet-1570	369	34	,	,	PUNCT
admet-1570	369	35	2	2	X
admet-1570	369	36	)	)	PUNCT
admet-1570	369	37	the	the	DET
admet-1570	369	38	steady	steady	ADJ
admet-1570	369	39	-	-	PUNCT
admet-1570	369	40	state	state	NOUN
admet-1570	369	41	lymph	lymph	NOUN
admet-1570	369	42	/	/	SYM
admet-1570	369	43	plasma	plasma	NOUN
admet-1570	369	44	protein	protein	NOUN
admet-1570	369	45	ratio	ratio	NOUN
admet-1570	369	46	(	(	PUNCT
admet-1570	369	47	eq	eq	NOUN
admet-1570	369	48	.	.	PROPN
admet-1570	369	49	5	5	NUM
admet-1570	369	50	)	)	PUNCT
admet-1570	369	51	,	,	PUNCT
admet-1570	369	52	3	3	X
admet-1570	369	53	)	)	PUNCT
admet-1570	369	54	the	the	DET
admet-1570	369	55	simultaneous	simultaneous	ADJ
admet-1570	369	56	plasma	plasma	NOUN
admet-1570	369	57	and	and	CCONJ
admet-1570	369	58	lymph	lymph	NOUN
admet-1570	369	59	protein	protein	NOUN
admet-1570	369	60	concentration	concentration	NOUN
admet-1570	369	61	following	follow	VERB
admet-1570	369	62	a	a	DET
admet-1570	369	63	bolus	bolus	ADJ
admet-1570	369	64	alt	alt	NOUN
admet-1570	369	65	iv	iv	NOUN
admet-1570	369	66	injection	injection	NOUN
admet-1570	369	67	(	(	PUNCT
admet-1570	369	68	figure	figure	NOUN
admet-1570	369	69	7	7	NUM
admet-1570	369	70	)	)	PUNCT
admet-1570	369	71	,	,	PUNCT
admet-1570	369	72	4	4	X
admet-1570	369	73	)	)	PUNCT
admet-1570	369	74	the	the	DET
admet-1570	369	75	plasma	plasma	NOUN
admet-1570	369	76	concentration	concentration	NOUN
admet-1570	369	77	following	follow	VERB
admet-1570	369	78	a	a	DET
admet-1570	369	79	subcutaneous	subcutaneous	ADJ
admet-1570	369	80	monoclonal	monoclonal	NOUN
admet-1570	369	81	antibody	antibody	NOUN
admet-1570	369	82	injection	injection	NOUN
admet-1570	369	83	(	(	PUNCT
admet-1570	369	84	fig	fig	NOUN
admet-1570	369	85	4	4	NUM
admet-1570	369	86	)	)	PUNCT
admet-1570	369	87	,	,	PUNCT
admet-1570	369	88	and	and	CCONJ
admet-1570	369	89	5	5	X
admet-1570	369	90	)	)	PUNCT
admet-1570	369	91	the	the	DET
admet-1570	369	92	plasma	plasma	NOUN
admet-1570	369	93	concentration	concentration	NOUN
admet-1570	369	94	of	of	ADP
admet-1570	369	95	iap	iap	PROPN
admet-1570	369	96	following	follow	VERB
admet-1570	369	97	a	a	DET
admet-1570	369	98	high	high	ADJ
admet-1570	369	99	-	-	PUNCT
admet-1570	369	100	fat	fat	NOUN
admet-1570	369	101	meal	meal	NOUN
admet-1570	369	102	(	(	PUNCT
admet-1570	369	103	figure	figure	NOUN
admet-1570	369	104	13	13	NUM
admet-1570	369	105	)	)	PUNCT
admet-1570	369	106	.	.	PUNCT
admet-1570	370	1	the	the	DET
admet-1570	370	2	validity	validity	NOUN
admet-1570	370	3	of	of	ADP
admet-1570	370	4	these	these	DET
admet-1570	370	5	predictions	prediction	NOUN
admet-1570	370	6	provides	provide	VERB
admet-1570	370	7	the	the	DET
admet-1570	370	8	strongest	strong	ADJ
admet-1570	370	9	available	available	ADJ
admet-1570	370	10	evidence	evidence	NOUN
admet-1570	370	11	in	in	ADP
admet-1570	370	12	support	support	NOUN
admet-1570	370	13	of	of	ADP
admet-1570	370	14	this	this	DET
admet-1570	370	15	simple	simple	ADJ
admet-1570	370	16	physiological	physiological	ADJ
admet-1570	370	17	model	model	NOUN
admet-1570	370	18	.	.	PUNCT
admet-1570	371	1	as	as	SCONJ
admet-1570	371	2	discussed	discuss	VERB
admet-1570	371	3	,	,	PUNCT
admet-1570	371	4	one	one	NUM
admet-1570	371	5	of	of	ADP
admet-1570	371	6	the	the	DET
admet-1570	371	7	assumptions	assumption	NOUN
admet-1570	371	8	of	of	ADP
admet-1570	371	9	the	the	DET
admet-1570	371	10	model	model	NOUN
admet-1570	371	11	is	be	AUX
admet-1570	371	12	that	that	SCONJ
admet-1570	371	13	,	,	PUNCT
admet-1570	371	14	for	for	ADP
admet-1570	371	15	a	a	DET
admet-1570	371	16	given	give	VERB
admet-1570	371	17	species	specie	NOUN
admet-1570	371	18	,	,	PUNCT
admet-1570	371	19	the	the	DET
admet-1570	371	20	sieving	sieve	VERB
admet-1570	371	21	coefficient	coefficient	NOUN
admet-1570	371	22	f	f	PROPN
admet-1570	371	23	should	should	AUX
admet-1570	371	24	decrease	decrease	VERB
admet-1570	371	25	as	as	ADP
admet-1570	371	26	its	its	PRON
admet-1570	371	27	molecular	molecular	ADJ
admet-1570	371	28	size	size	NOUN
admet-1570	371	29	increases	increase	VERB
admet-1570	371	30	.	.	PUNCT
admet-1570	372	1	the	the	DET
admet-1570	372	2	results	result	NOUN
admet-1570	372	3	in	in	ADP
admet-1570	372	4	the	the	DET
admet-1570	372	5	human	human	NOUN
admet-1570	372	6	are	be	AUX
admet-1570	372	7	consistent	consistent	ADJ
admet-1570	372	8	with	with	ADP
admet-1570	372	9	this	this	DET
admet-1570	372	10	assumption	assumption	NOUN
admet-1570	372	11	with	with	ADP
admet-1570	372	12	an	an	DET
admet-1570	372	13	f	f	NOUN
admet-1570	372	14	=	=	NOUN
admet-1570	372	15	0.73	0.73	NUM
admet-1570	372	16	for	for	ADP
admet-1570	372	17	albumin	albumin	NOUN
admet-1570	372	18	(	(	PUNCT
admet-1570	372	19	mol	mol	ADP
admet-1570	372	20	wt=	wt=	VERB
admet-1570	372	21	66,500	66,500	NUM
admet-1570	372	22	)	)	PUNCT
admet-1570	372	23	and	and	CCONJ
admet-1570	372	24	a	a	DET
admet-1570	372	25	smaller	small	ADJ
admet-1570	372	26	f	f	NOUN
admet-1570	372	27	=	=	NOUN
admet-1570	372	28	0.367	0.367	NUM
admet-1570	372	29	for	for	ADP
admet-1570	372	30	the	the	DET
admet-1570	372	31	larger	large	ADJ
admet-1570	372	32	monoclonal	monoclonal	NOUN
admet-1570	372	33	antibodies	antibody	NOUN
admet-1570	372	34	(	(	PUNCT
admet-1570	372	35	mol	mol	ADP
admet-1570	372	36	wt	wt	NOUN
admet-1570	372	37	=	=	NOUN
admet-1570	372	38	149,000	149,000	NUM
admet-1570	372	39	)	)	PUNCT
admet-1570	372	40	and	and	CCONJ
admet-1570	372	41	similar	similar	ADJ
admet-1570	372	42	size	size	NOUN
admet-1570	372	43	alkaline	alkaline	NOUN
admet-1570	372	44	phosphatase	phosphatase	NOUN
admet-1570	372	45	(	(	PUNCT
admet-1570	372	46	mol	mol	ADP
admet-1570	372	47	wt	wt	NOUN
admet-1570	372	48	=	=	NOUN
admet-1570	372	49	140,000	140,000	NUM
admet-1570	372	50	)	)	PUNCT
admet-1570	372	51	.	.	PUNCT
admet-1570	373	1	the	the	DET
admet-1570	373	2	dog	dog	NOUN
admet-1570	373	3	results	result	NOUN
admet-1570	373	4	are	be	AUX
admet-1570	373	5	also	also	ADV
admet-1570	373	6	consistent	consistent	ADJ
admet-1570	373	7	:	:	PUNCT
admet-1570	373	8	f=	f=	NOUN
admet-1570	373	9	0.53	0.53	NUM
admet-1570	373	10	for	for	ADP
admet-1570	373	11	alanine	alanine	NOUN
admet-1570	373	12	transaminase	transaminase	NOUN
admet-1570	373	13	(	(	PUNCT
admet-1570	373	14	mw	mw	NOUN
admet-1570	373	15	=	=	NOUN
admet-1570	373	16	54,600	54,600	NUM
admet-1570	373	17	)	)	PUNCT
admet-1570	373	18	and	and	CCONJ
admet-1570	373	19	similar	similar	ADJ
admet-1570	373	20	-	-	PUNCT
admet-1570	373	21	sized	sized	ADJ
admet-1570	373	22	mitochondrial	mitochondrial	ADJ
admet-1570	373	23	and	and	CCONJ
admet-1570	373	24	cytoplasmic	cytoplasmic	ADJ
admet-1570	373	25	aspartate	aspartate	NOUN
admet-1570	373	26	aminotransferase	aminotransferase	NOUN
admet-1570	373	27	(	(	PUNCT
admet-1570	373	28	mw	mw	X
admet-1570	373	29	47,000	47,000	NUM
admet-1570	373	30	)	)	PUNCT
admet-1570	373	31	and	and	CCONJ
admet-1570	373	32	f	f	X
admet-1570	373	33	=	=	SYM
admet-1570	373	34	0.37	0.37	NUM
admet-1570	373	35	for	for	ADP
admet-1570	373	36	the	the	DET
admet-1570	373	37	larger	large	ADJ
admet-1570	373	38	creatine	creatine	NOUN
admet-1570	373	39	kinase	kinase	PROPN
admet-1570	373	40	(	(	PUNCT
admet-1570	373	41	mw	mw	X
admet-1570	373	42	=	=	NOUN
admet-1570	373	43	81,000	81,000	NUM
admet-1570	373	44	)	)	PUNCT
admet-1570	373	45	.	.	PUNCT
admet-1570	374	1	although	although	SCONJ
admet-1570	374	2	one	one	PRON
admet-1570	374	3	could	could	AUX
admet-1570	374	4	use	use	VERB
admet-1570	374	5	these	these	DET
admet-1570	374	6	results	result	NOUN
admet-1570	374	7	to	to	PART
admet-1570	374	8	try	try	VERB
admet-1570	374	9	to	to	PART
admet-1570	374	10	estimate	estimate	VERB
admet-1570	374	11	an	an	DET
admet-1570	374	12	“	"	PUNCT
admet-1570	374	13	equivalent	equivalent	ADJ
admet-1570	374	14	capillary	capillary	ADJ
admet-1570	374	15	pore	pore	ADJ
admet-1570	374	16	radius	radius	NOUN
admet-1570	374	17	”	"	PUNCT
admet-1570	375	1	[	[	X
admet-1570	375	2	63	63	NUM
admet-1570	375	3	]	]	PUNCT
admet-1570	375	4	,	,	PUNCT
admet-1570	375	5	the	the	DET
admet-1570	375	6	data	datum	NOUN
admet-1570	375	7	are	be	AUX
admet-1570	375	8	too	too	ADV
admet-1570	375	9	limited	limited	ADJ
admet-1570	375	10	to	to	PART
admet-1570	375	11	put	put	VERB
admet-1570	375	12	much	much	ADJ
admet-1570	375	13	confidence	confidence	NOUN
admet-1570	375	14	in	in	ADP
admet-1570	375	15	these	these	DET
admet-1570	375	16	results	result	NOUN
admet-1570	375	17	.	.	PUNCT
admet-1570	376	1	note	note	VERB
admet-1570	376	2	that	that	SCONJ
admet-1570	376	3	these	these	DET
admet-1570	376	4	results	result	NOUN
admet-1570	376	5	also	also	ADV
admet-1570	376	6	suggest	suggest	VERB
admet-1570	376	7	that	that	SCONJ
admet-1570	376	8	the	the	DET
admet-1570	376	9	equivalent	equivalent	ADJ
admet-1570	376	10	pore	pore	ADJ
admet-1570	376	11	radius	radius	NOUN
admet-1570	376	12	in	in	ADP
admet-1570	376	13	the	the	DET
admet-1570	376	14	human	human	NOUN
admet-1570	376	15	is	be	AUX
admet-1570	376	16	larger	large	ADJ
admet-1570	376	17	than	than	ADP
admet-1570	376	18	that	that	PRON
admet-1570	376	19	in	in	ADP
admet-1570	376	20	the	the	DET
admet-1570	376	21	dog	dog	NOUN
admet-1570	376	22	.	.	PUNCT
admet-1570	377	1	this	this	DET
admet-1570	377	2	review	review	NOUN
admet-1570	377	3	is	be	AUX
admet-1570	377	4	the	the	DET
admet-1570	377	5	first	first	ADJ
admet-1570	377	6	that	that	SCONJ
admet-1570	377	7	we	we	PRON
admet-1570	377	8	are	be	AUX
admet-1570	377	9	aware	aware	ADJ
admet-1570	377	10	of	of	ADP
admet-1570	377	11	that	that	PRON
admet-1570	377	12	uses	use	VERB
admet-1570	377	13	a	a	DET
admet-1570	377	14	simple	simple	ADJ
admet-1570	377	15	physiological	physiological	ADJ
admet-1570	377	16	model	model	NOUN
admet-1570	377	17	to	to	PART
admet-1570	377	18	describe	describe	VERB
admet-1570	377	19	a	a	DET
admet-1570	377	20	comprehensive	comprehensive	ADJ
admet-1570	377	21	framework	framework	NOUN
admet-1570	377	22	for	for	ADP
admet-1570	377	23	cataloguing	catalogue	VERB
admet-1570	377	24	the	the	DET
admet-1570	377	25	results	result	NOUN
admet-1570	377	26	of	of	ADP
admet-1570	377	27	protein	protein	NOUN
admet-1570	377	28	pk	pk	NOUN
admet-1570	377	29	studies	study	NOUN
admet-1570	377	30	(	(	PUNCT
admet-1570	377	31	table	table	NOUN
admet-1570	377	32	2	2	NUM
admet-1570	377	33	)	)	PUNCT
admet-1570	377	34	.	.	PUNCT
admet-1570	378	1	the	the	DET
admet-1570	378	2	parameters	parameter	NOUN
admet-1570	378	3	are	be	AUX
admet-1570	378	4	consistent	consistent	ADJ
admet-1570	378	5	with	with	ADP
admet-1570	378	6	the	the	DET
admet-1570	378	7	constraints	constraint	NOUN
admet-1570	378	8	placed	place	VERB
admet-1570	378	9	on	on	ADP
admet-1570	378	10	them	they	PRON
admet-1570	378	11	by	by	ADP
admet-1570	378	12	the	the	DET
admet-1570	378	13	model	model	NOUN
admet-1570	378	14	,	,	PUNCT
admet-1570	378	15	i.e.	i.e.	X
admet-1570	378	16	,	,	PUNCT
admet-1570	378	17	the	the	DET
admet-1570	378	18	same	same	ADJ
admet-1570	378	19	v1	v1	NOUN
admet-1570	378	20	,	,	PUNCT
admet-1570	378	21	v2	v2	PROPN
admet-1570	378	22	,	,	PUNCT
admet-1570	378	23	l1	l1	PROPN
admet-1570	378	24	and	and	CCONJ
admet-1570	378	25	l2	l2	NOUN
admet-1570	378	26	for	for	ADP
admet-1570	378	27	all	all	DET
admet-1570	378	28	proteins	protein	NOUN
admet-1570	378	29	in	in	ADP
admet-1570	378	30	the	the	DET
admet-1570	378	31	same	same	ADJ
admet-1570	378	32	species	specie	NOUN
admet-1570	378	33	,	,	PUNCT
admet-1570	378	34	and	and	CCONJ
admet-1570	378	35	f	f	PROPN
admet-1570	378	36	decreases	decrease	VERB
admet-1570	378	37	as	as	ADP
admet-1570	378	38	molecular	molecular	ADJ
admet-1570	378	39	weight	weight	NOUN
admet-1570	378	40	increases	increase	NOUN
admet-1570	378	41	.	.	PUNCT
admet-1570	379	1	even	even	ADV
admet-1570	379	2	considering	consider	VERB
admet-1570	379	3	species	specie	NOUN
admet-1570	379	4	variations	variation	NOUN
admet-1570	379	5	,	,	PUNCT
admet-1570	379	6	the	the	DET
admet-1570	379	7	plasma	plasma	NOUN
admet-1570	379	8	clearance	clearance	NOUN
admet-1570	379	9	(	(	PUNCT
admet-1570	379	10	clp	clp	PROPN
admet-1570	379	11	)	)	PUNCT
admet-1570	379	12	is	be	AUX
admet-1570	379	13	the	the	DET
admet-1570	379	14	main	main	ADJ
admet-1570	379	15	pk	pk	NOUN
admet-1570	379	16	determinant	determinant	ADJ
admet-1570	379	17	,	,	PUNCT
admet-1570	379	18	varying	vary	VERB
admet-1570	379	19	by	by	ADP
admet-1570	379	20	more	more	ADJ
admet-1570	379	21	than	than	ADP
admet-1570	379	22	400	400	NUM
admet-1570	379	23	-	-	NUM
admet-1570	379	24	fold	fold	VERB
admet-1570	379	25	,	,	PUNCT
admet-1570	379	26	with	with	ADP
admet-1570	379	27	the	the	DET
admet-1570	379	28	other	other	ADJ
admet-1570	379	29	parameters	parameter	NOUN
admet-1570	379	30	varying	vary	VERB
admet-1570	379	31	by	by	ADP
admet-1570	379	32	about	about	ADV
admet-1570	379	33	2	2	NUM
admet-1570	379	34	-	-	NUM
admet-1570	379	35	fold	fold	ADJ
admet-1570	379	36	.	.	PUNCT
admet-1570	380	1	the	the	DET
admet-1570	380	2	one	one	NUM
admet-1570	380	3	protein	protein	NOUN
admet-1570	380	4	that	that	PRON
admet-1570	380	5	did	do	AUX
admet-1570	380	6	not	not	PART
admet-1570	380	7	fit	fit	VERB
admet-1570	380	8	this	this	DET
admet-1570	380	9	simple	simple	ADJ
admet-1570	380	10	convection	convection	NOUN
admet-1570	380	11	model	model	NOUN
admet-1570	380	12	was	be	AUX
admet-1570	380	13	the	the	DET
admet-1570	380	14	intestinal	intestinal	ADJ
admet-1570	380	15	isoform	isoform	NOUN
admet-1570	380	16	(	(	PUNCT
admet-1570	380	17	recap	recap	NOUN
admet-1570	380	18	)	)	PUNCT
admet-1570	380	19	of	of	ADP
admet-1570	380	20	the	the	DET
admet-1570	380	21	glycoprotein	glycoprotein	NOUN
admet-1570	380	22	alp	alp	PROPN
admet-1570	380	23	.	.	PUNCT
admet-1570	381	1	the	the	DET
admet-1570	381	2	recap	recap	NOUN
admet-1570	381	3	pk	pk	NOUN
admet-1570	381	4	is	be	AUX
admet-1570	381	5	dramatically	dramatically	ADV
admet-1570	381	6	biphasic	biphasic	ADJ
admet-1570	381	7	.	.	PUNCT
admet-1570	382	1	in	in	ADP
admet-1570	382	2	the	the	DET
admet-1570	382	3	first	first	ADJ
admet-1570	382	4	(	(	PUNCT
admet-1570	382	5	distribution	distribution	NOUN
admet-1570	382	6	)	)	PUNCT
admet-1570	382	7	phase	phase	NOUN
admet-1570	382	8	,	,	PUNCT
admet-1570	382	9	the	the	DET
admet-1570	382	10	plasma	plasma	NOUN
admet-1570	382	11	concentration	concentration	NOUN
admet-1570	382	12	falls	fall	VERB
admet-1570	382	13	to	to	ADP
admet-1570	382	14	about	about	ADV
admet-1570	382	15	5	5	NUM
admet-1570	382	16	%	%	NOUN
admet-1570	382	17	of	of	ADP
admet-1570	382	18	its	its	PRON
admet-1570	382	19	initial	initial	ADJ
admet-1570	382	20	value	value	NOUN
admet-1570	382	21	in	in	ADP
admet-1570	382	22	4	4	NUM
admet-1570	382	23	hours	hour	NOUN
admet-1570	382	24	(	(	PUNCT
admet-1570	382	25	see	see	VERB
admet-1570	382	26	figure	figure	NOUN
admet-1570	382	27	10	10	NUM
admet-1570	382	28	)	)	PUNCT
admet-1570	382	29	.	.	PUNCT
admet-1570	383	1	since	since	SCONJ
admet-1570	383	2	an	an	DET
admet-1570	383	3	impossibly	impossibly	ADV
admet-1570	383	4	large	large	ADJ
admet-1570	383	5	space	space	NOUN
admet-1570	383	6	of	of	ADP
admet-1570	383	7	about	about	ADV
admet-1570	383	8	24	24	NUM
admet-1570	383	9	liters	liter	NOUN
admet-1570	383	10	would	would	AUX
admet-1570	383	11	be	be	AUX
admet-1570	383	12	required	require	VERB
admet-1570	383	13	to	to	PART
admet-1570	383	14	account	account	VERB
admet-1570	383	15	for	for	ADP
admet-1570	383	16	such	such	DET
admet-1570	383	17	a	a	DET
admet-1570	383	18	distribution	distribution	NOUN
admet-1570	383	19	,	,	PUNCT
admet-1570	383	20	it	it	PRON
admet-1570	383	21	appears	appear	VERB
admet-1570	383	22	that	that	SCONJ
admet-1570	383	23	its	its	PRON
admet-1570	383	24	initial	initial	ADJ
admet-1570	383	25	disappearance	disappearance	NOUN
admet-1570	383	26	phase	phase	NOUN
admet-1570	383	27	is	be	AUX
admet-1570	383	28	attributable	attributable	ADJ
admet-1570	383	29	almost	almost	ADV
admet-1570	383	30	entirely	entirely	ADV
admet-1570	383	31	to	to	ADP
admet-1570	383	32	receptor	receptor	VERB
admet-1570	383	33	binding	bind	VERB
admet-1570	383	34	with	with	ADP
admet-1570	383	35	rapid	rapid	ADJ
admet-1570	383	36	recycling	recycling	NOUN
admet-1570	383	37	in	in	ADP
admet-1570	383	38	the	the	DET
admet-1570	383	39	liver	liver	NOUN
admet-1570	383	40	.	.	PUNCT
admet-1570	384	1	metabolism	metabolism	NOUN
admet-1570	384	2	is	be	AUX
admet-1570	384	3	negligible	negligible	ADJ
admet-1570	384	4	during	during	ADP
admet-1570	384	5	this	this	DET
admet-1570	384	6	distribution	distribution	NOUN
admet-1570	384	7	phase	phase	NOUN
admet-1570	384	8	(	(	PUNCT
admet-1570	384	9	figure	figure	NOUN
admet-1570	384	10	12	12	NUM
admet-1570	384	11	)	)	PUNCT
admet-1570	384	12	.	.	PUNCT
admet-1570	385	1	the	the	DET
admet-1570	385	2	second	second	ADJ
admet-1570	385	3	slow	slow	ADJ
admet-1570	385	4	metabolic	metabolic	NOUN
admet-1570	385	5	phase	phase	NOUN
admet-1570	385	6	only	only	ADV
admet-1570	385	7	becomes	become	VERB
admet-1570	385	8	apparent	apparent	ADJ
admet-1570	385	9	at	at	ADP
admet-1570	385	10	long	long	ADJ
admet-1570	385	11	time	time	NOUN
admet-1570	385	12	periods	period	NOUN
admet-1570	385	13	,	,	PUNCT
admet-1570	385	14	and	and	CCONJ
admet-1570	385	15	the	the	DET
admet-1570	385	16	24	24	NUM
admet-1570	385	17	-	-	PUNCT
admet-1570	385	18	hour	hour	NOUN
admet-1570	385	19	data	datum	NOUN
admet-1570	385	20	used	use	VERB
admet-1570	385	21	in	in	ADP
admet-1570	385	22	figure	figure	NOUN
admet-1570	385	23	12	12	NUM
admet-1570	385	24	may	may	AUX
admet-1570	385	25	not	not	PART
admet-1570	385	26	be	be	AUX
admet-1570	385	27	long	long	ADJ
admet-1570	385	28	enough	enough	ADV
admet-1570	385	29	for	for	ADP
admet-1570	385	30	an	an	DET
admet-1570	385	31	accurate	accurate	ADJ
admet-1570	385	32	estimate	estimate	NOUN
admet-1570	385	33	of	of	ADP
admet-1570	385	34	the	the	DET
admet-1570	385	35	metabolism	metabolism	NOUN
admet-1570	385	36	.	.	PUNCT
admet-1570	386	1	this	this	DET
admet-1570	386	2	result	result	NOUN
admet-1570	386	3	illustrates	illustrate	VERB
admet-1570	386	4	one	one	NUM
admet-1570	386	5	of	of	ADP
admet-1570	386	6	the	the	DET
admet-1570	386	7	main	main	ADJ
admet-1570	386	8	advantages	advantage	NOUN
admet-1570	386	9	of	of	ADP
admet-1570	386	10	using	use	VERB
admet-1570	386	11	a	a	DET
admet-1570	386	12	physiological	physiological	ADJ
admet-1570	386	13	model	model	NOUN
admet-1570	386	14	.	.	PUNCT
admet-1570	387	1	although	although	SCONJ
admet-1570	387	2	one	one	PRON
admet-1570	387	3	can	can	AUX
admet-1570	387	4	always	always	ADV
admet-1570	387	5	fit	fit	VERB
admet-1570	387	6	the	the	DET
admet-1570	387	7	data	datum	NOUN
admet-1570	387	8	with	with	ADP
admet-1570	387	9	a	a	DET
admet-1570	387	10	compartment	compartment	NOUN
admet-1570	387	11	model	model	NOUN
admet-1570	387	12	with	with	ADP
admet-1570	387	13	its	its	PRON
admet-1570	387	14	5	5	NUM
admet-1570	387	15	adjustable	adjustable	ADJ
admet-1570	387	16	parameters	parameter	NOUN
admet-1570	387	17	,	,	PUNCT
admet-1570	387	18	using	use	VERB
admet-1570	387	19	the	the	DET
admet-1570	387	20	much	much	ADV
admet-1570	387	21	more	more	ADV
admet-1570	387	22	constrained	constrained	ADJ
admet-1570	387	23	physiological	physiological	ADJ
admet-1570	387	24	model	model	NOUN
admet-1570	387	25	(	(	PUNCT
admet-1570	387	26	2	2	NUM
admet-1570	387	27	adjustable	adjustable	ADJ
admet-1570	387	28	parameters	parameter	NOUN
admet-1570	387	29	)	)	PUNCT
admet-1570	387	30	can	can	AUX
admet-1570	387	31	provide	provide	VERB
admet-1570	387	32	unequivocal	unequivocal	ADJ
admet-1570	387	33	evidence	evidence	NOUN
admet-1570	387	34	that	that	SCONJ
admet-1570	387	35	the	the	DET
admet-1570	387	36	model	model	NOUN
admet-1570	387	37	is	be	AUX
admet-1570	387	38	wrong	wrong	ADJ
admet-1570	387	39	and	and	CCONJ
admet-1570	387	40	that	that	SCONJ
admet-1570	387	41	the	the	DET
admet-1570	387	42	compound	compound	NOUN
admet-1570	387	43	under	under	ADP
admet-1570	387	44	study	study	NOUN
admet-1570	387	45	must	must	AUX
admet-1570	387	46	belong	belong	VERB
admet-1570	387	47	to	to	ADP
admet-1570	387	48	a	a	DET
admet-1570	387	49	significantly	significantly	ADV
admet-1570	387	50	different	different	ADJ
admet-1570	387	51	pk	pk	NOUN
admet-1570	387	52	class	class	NOUN
admet-1570	387	53	.	.	PUNCT
admet-1570	388	1	in	in	ADP
admet-1570	388	2	going	go	VERB
admet-1570	388	3	to	to	ADP
admet-1570	388	4	the	the	DET
admet-1570	388	5	simplified	simplified	ADJ
admet-1570	388	6	2	2	NUM
admet-1570	388	7	tissue	tissue	NOUN
admet-1570	388	8	compartment	compartment	NOUN
admet-1570	388	9	lumped	lump	VERB
admet-1570	388	10	physiological	physiological	ADJ
admet-1570	388	11	model	model	NOUN
admet-1570	388	12	,	,	PUNCT
admet-1570	388	13	one	one	PRON
admet-1570	388	14	gives	give	VERB
admet-1570	388	15	up	up	ADP
admet-1570	388	16	the	the	DET
admet-1570	388	17	potential	potential	NOUN
admet-1570	388	18	of	of	ADP
admet-1570	388	19	predicting	predict	VERB
admet-1570	388	20	the	the	DET
admet-1570	388	21	detailed	detailed	ADJ
admet-1570	388	22	individual	individual	ADJ
admet-1570	388	23	tissue	tissue	NOUN
admet-1570	388	24	pk	pk	NOUN
admet-1570	388	25	in	in	ADP
admet-1570	388	26	the	the	DET
admet-1570	388	27	13	13	NUM
admet-1570	388	28	or	or	CCONJ
admet-1570	388	29	more	more	ADJ
admet-1570	388	30	organs	organ	NOUN
admet-1570	388	31	of	of	ADP
admet-1570	388	32	the	the	DET
admet-1570	388	33	full	full	ADJ
admet-1570	388	34	pbpk	pbpk	ADJ
admet-1570	388	35	model	model	NOUN
admet-1570	388	36	.	.	PUNCT
admet-1570	389	1	however	however	ADV
admet-1570	389	2	,	,	PUNCT
admet-1570	389	3	given	give	VERB
admet-1570	389	4	the	the	DET
admet-1570	389	5	limited	limited	ADJ
admet-1570	389	6	knowledge	knowledge	NOUN
admet-1570	389	7	,	,	PUNCT
admet-1570	389	8	at	at	ADP
admet-1570	389	9	least	least	ADJ
admet-1570	389	10	in	in	ADP
admet-1570	389	11	the	the	DET
admet-1570	389	12	human	human	NOUN
admet-1570	389	13	,	,	PUNCT
admet-1570	389	14	of	of	ADP
admet-1570	389	15	each	each	DET
admet-1570	389	16	organ	organ	NOUN
admet-1570	389	17	’s	’s	PART
admet-1570	389	18	lymph	lymph	NOUN
admet-1570	389	19	flow	flow	NOUN
admet-1570	389	20	,	,	PUNCT
admet-1570	389	21	volume	volume	NOUN
admet-1570	389	22	,	,	PUNCT
admet-1570	389	23	and	and	CCONJ
admet-1570	389	24	sieving	sieve	VERB
admet-1570	389	25	coefficient	coefficient	NOUN
admet-1570	389	26	,	,	PUNCT
admet-1570	389	27	this	this	PRON
admet-1570	389	28	is	be	AUX
admet-1570	389	29	more	more	ADJ
admet-1570	389	30	of	of	ADP
admet-1570	389	31	a	a	DET
admet-1570	389	32	theoretical	theoretical	ADJ
admet-1570	389	33	than	than	ADP
admet-1570	389	34	a	a	DET
admet-1570	389	35	practical	practical	ADJ
admet-1570	389	36	limitation	limitation	NOUN
admet-1570	389	37	.	.	PUNCT
admet-1570	390	1	the	the	DET
admet-1570	390	2	two	two	NUM
admet-1570	390	3	lumped	lump	VERB
admet-1570	390	4	tissue	tissue	NOUN
admet-1570	390	5	compartments	compartment	NOUN
admet-1570	390	6	(	(	PUNCT
admet-1570	390	7	v1	v1	NOUN
admet-1570	390	8	and	and	CCONJ
admet-1570	390	9	v2	v2	NOUN
admet-1570	390	10	)	)	PUNCT
admet-1570	390	11	in	in	ADP
admet-1570	390	12	our	our	PRON
admet-1570	390	13	simplified	simplified	ADJ
admet-1570	390	14	model	model	NOUN
admet-1570	390	15	are	be	AUX
admet-1570	390	16	surprisingly	surprisingly	ADV
admet-1570	390	17	good	good	ADJ
admet-1570	390	18	at	at	ADP
admet-1570	390	19	simulating	simulate	VERB
admet-1570	390	20	tissue	tissue	NOUN
admet-1570	390	21	input	input	NOUN
admet-1570	390	22	.	.	PUNCT
admet-1570	391	1	for	for	ADP
admet-1570	391	2	example	example	NOUN
admet-1570	391	3	,	,	PUNCT
admet-1570	391	4	the	the	DET
admet-1570	391	5	plasma	plasma	NOUN
admet-1570	391	6	concentration	concentration	NOUN
admet-1570	391	7	following	follow	VERB
admet-1570	391	8	a	a	DET
admet-1570	391	9	subcutaneous	subcutaneous	ADJ
admet-1570	391	10	injection	injection	NOUN
admet-1570	391	11	is	be	AUX
admet-1570	391	12	well	well	ADV
admet-1570	391	13	simulated	simulate	VERB
admet-1570	391	14	by	by	ADP
admet-1570	391	15	injection	injection	NOUN
admet-1570	391	16	into	into	ADP
admet-1570	391	17	the	the	DET
admet-1570	391	18	slow	slow	ADJ
admet-1570	391	19	turnover	turnover	NOUN
admet-1570	391	20	v1	v1	NOUN
admet-1570	391	21	compartment	compartment	NOUN
admet-1570	391	22	(	(	PUNCT
admet-1570	391	23	figure	figure	NOUN
admet-1570	391	24	4	4	NUM
admet-1570	391	25	)	)	PUNCT
admet-1570	391	26	and	and	CCONJ
admet-1570	391	27	the	the	DET
admet-1570	391	28	plasma	plasma	NOUN
admet-1570	391	29	concentration	concentration	NOUN
admet-1570	391	30	following	follow	VERB
admet-1570	391	31	gastrointestinal	gastrointestinal	ADJ
admet-1570	391	32	tissue	tissue	NOUN
admet-1570	391	33	input	input	NOUN
admet-1570	391	34	can	can	AUX
admet-1570	391	35	be	be	AUX
admet-1570	391	36	predicted	predict	VERB
admet-1570	391	37	by	by	ADP
admet-1570	391	38	input	input	NOUN
admet-1570	391	39	into	into	ADP
admet-1570	391	40	the	the	DET
admet-1570	391	41	fast	fast	ADJ
admet-1570	391	42	turnover	turnover	NOUN
admet-1570	391	43	v2	v2	NOUN
admet-1570	391	44	compartment	compartment	NOUN
admet-1570	391	45	(	(	PUNCT
admet-1570	391	46	figure	figure	NOUN
admet-1570	391	47	13	13	NUM
admet-1570	391	48	)	)	PUNCT
admet-1570	391	49	.	.	PUNCT
admet-1570	392	1	we	we	PRON
admet-1570	392	2	believe	believe	VERB
admet-1570	392	3	that	that	SCONJ
admet-1570	392	4	the	the	DET
admet-1570	392	5	physiological	physiological	ADJ
admet-1570	392	6	model	model	NOUN
admet-1570	392	7	’s	’s	PART
admet-1570	392	8	simplicity	simplicity	NOUN
admet-1570	392	9	and	and	CCONJ
admet-1570	392	10	ability	ability	NOUN
admet-1570	392	11	to	to	PART
admet-1570	392	12	describe	describe	VERB
admet-1570	392	13	the	the	DET
admet-1570	392	14	plasma	plasma	NOUN
admet-1570	392	15	and	and	CCONJ
admet-1570	392	16	lymph	lymph	NOUN
admet-1570	392	17	concentration	concentration	NOUN
admet-1570	392	18	for	for	ADP
admet-1570	392	19	a	a	DET
admet-1570	392	20	wide	wide	ADJ
admet-1570	392	21	range	range	NOUN
admet-1570	392	22	of	of	ADP
admet-1570	392	23	proteins	protein	NOUN
admet-1570	392	24	compensates	compensate	NOUN
admet-1570	392	25	for	for	ADP
admet-1570	392	26	its	its	PRON
admet-1570	392	27	theoretical	theoretical	ADJ
admet-1570	392	28	limitations	limitation	NOUN
admet-1570	392	29	.	.	PUNCT
admet-1570	393	1	admet	admet	PROPN
admet-1570	393	2	&	&	CCONJ
admet-1570	393	3	dmpk	dmpk	PROPN
admet-1570	393	4	11(1	11(1	NUM
admet-1570	393	5	)	)	PUNCT
admet-1570	393	6	(	(	PUNCT
admet-1570	393	7	2023	2023	NUM
admet-1570	393	8	)	)	PUNCT
admet-1570	393	9	57	57	NUM
admet-1570	393	10	-	-	SYM
admet-1570	393	11	80	80	NUM
admet-1570	393	12	protein	protein	NOUN
admet-1570	393	13	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	393	14	model	model	NOUN
admet-1570	393	15	doi	doi	NOUN
admet-1570	393	16	:	:	PUNCT
admet-1570	393	17	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	393	18	77	77	NUM
admet-1570	393	19	conflict	conflict	NOUN
admet-1570	393	20	of	of	ADP
admet-1570	393	21	interest	interest	NOUN
admet-1570	393	22	:	:	PUNCT
admet-1570	393	23	the	the	DET
admet-1570	393	24	authors	author	NOUN
admet-1570	393	25	report	report	VERB
admet-1570	393	26	no	no	DET
admet-1570	393	27	conflicts	conflict	NOUN
admet-1570	393	28	of	of	ADP
admet-1570	393	29	interest	interest	NOUN
admet-1570	393	30	in	in	ADP
admet-1570	393	31	this	this	DET
admet-1570	393	32	work	work	NOUN
admet-1570	393	33	.	.	PUNCT
admet-1570	394	1	references	reference	NOUN
admet-1570	394	2	[	[	X
admet-1570	394	3	1	1	NUM
admet-1570	394	4	]	]	X
admet-1570	394	5	j.f	j.f	PROPN
admet-1570	394	6	.	.	PROPN
admet-1570	394	7	brandse	brandse	PROPN
admet-1570	394	8	,	,	PUNCT
admet-1570	394	9	d.	d.	PROPN
admet-1570	394	10	mould	mould	PROPN
admet-1570	394	11	,	,	PUNCT
admet-1570	394	12	o.	o.	PROPN
admet-1570	394	13	smeekes	smeekes	PROPN
admet-1570	394	14	,	,	PUNCT
admet-1570	394	15	y.	y.	PROPN
admet-1570	394	16	ashruf	ashruf	PROPN
admet-1570	394	17	,	,	PUNCT
admet-1570	394	18	s.	s.	PROPN
admet-1570	394	19	kuin	kuin	PROPN
admet-1570	394	20	,	,	PUNCT
admet-1570	394	21	a.	a.	PROPN
admet-1570	394	22	strik	strik	PROPN
admet-1570	394	23	,	,	PUNCT
admet-1570	394	24	g.r	g.r	PROPN
admet-1570	394	25	.	.	PROPN
admet-1570	395	1	van	van	PROPN
admet-1570	395	2	den	den	PROPN
admet-1570	395	3	brink	brink	PROPN
admet-1570	395	4	,	,	PUNCT
admet-1570	395	5	g.r	g.r	PROPN
admet-1570	395	6	.	.	PROPN
admet-1570	395	7	d'haens	d'haens	PROPN
admet-1570	395	8	.	.	PUNCT
admet-1570	396	1	a	a	DET
admet-1570	396	2	reallife	reallife	NOUN
admet-1570	396	3	population	population	NOUN
admet-1570	396	4	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	396	5	study	study	NOUN
admet-1570	396	6	reveals	reveal	VERB
admet-1570	396	7	factors	factor	NOUN
admet-1570	396	8	associated	associate	VERB
admet-1570	396	9	with	with	ADP
admet-1570	396	10	clearance	clearance	NOUN
admet-1570	396	11	and	and	CCONJ
admet-1570	396	12	immunogenicity	immunogenicity	NOUN
admet-1570	396	13	of	of	ADP
admet-1570	396	14	infliximab	infliximab	NOUN
admet-1570	396	15	in	in	ADP
admet-1570	396	16	inflammatory	inflammatory	ADJ
admet-1570	396	17	bowel	bowel	NOUN
admet-1570	396	18	disease	disease	NOUN
admet-1570	396	19	.	.	PUNCT
admet-1570	397	1	inflamm	inflamm	PROPN
admet-1570	397	2	bowel	bowel	PROPN
admet-1570	397	3	dis	dis	PROPN
admet-1570	397	4	23	23	NUM
admet-1570	397	5	(	(	PUNCT
admet-1570	397	6	2017	2017	NUM
admet-1570	397	7	)	)	PUNCT
admet-1570	397	8	650	650	NUM
admet-1570	397	9	-	-	SYM
admet-1570	397	10	660	660	NUM
admet-1570	397	11	.	.	PUNCT
admet-1570	398	1	https://doi.org/10.1097/mib.0000000000001043	https://doi.org/10.1097/mib.0000000000001043	NOUN
admet-1570	398	2	.	.	PUNCT
admet-1570	399	1	[	[	X
admet-1570	399	2	2	2	NUM
admet-1570	399	3	]	]	X
admet-1570	399	4	a.a	a.a	PROPN
admet-1570	399	5	.	.	PROPN
admet-1570	399	6	fasanmade	fasanmade	PROPN
admet-1570	399	7	,	,	PUNCT
admet-1570	399	8	o.j	o.j	PROPN
admet-1570	399	9	.	.	PROPN
admet-1570	399	10	adedokun	adedokun	PROPN
admet-1570	399	11	,	,	PUNCT
admet-1570	399	12	j.	j.	PROPN
admet-1570	399	13	ford	ford	PROPN
admet-1570	399	14	,	,	PUNCT
admet-1570	399	15	d.	d.	PROPN
admet-1570	399	16	hernandez	hernandez	PROPN
admet-1570	399	17	,	,	PUNCT
admet-1570	399	18	j.	j.	PROPN
admet-1570	399	19	johanns	johanns	PROPN
admet-1570	399	20	,	,	PUNCT
admet-1570	399	21	c.	c.	PROPN
admet-1570	399	22	hu	hu	PROPN
admet-1570	399	23	,	,	PUNCT
admet-1570	399	24	h.m	h.m	PROPN
admet-1570	399	25	.	.	PROPN
admet-1570	399	26	davis	davis	PROPN
admet-1570	399	27	,	,	PUNCT
admet-1570	399	28	h.	h.	PROPN
admet-1570	399	29	zhou	zhou	PROPN
admet-1570	399	30	.	.	PUNCT
admet-1570	400	1	population	population	NOUN
admet-1570	400	2	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	400	3	analysis	analysis	NOUN
admet-1570	400	4	of	of	ADP
admet-1570	400	5	infliximab	infliximab	NOUN
admet-1570	400	6	in	in	ADP
admet-1570	400	7	patients	patient	NOUN
admet-1570	400	8	with	with	ADP
admet-1570	400	9	ulcerative	ulcerative	ADJ
admet-1570	400	10	colitis	colitis	NOUN
admet-1570	400	11	.	.	PUNCT
admet-1570	401	1	eur	eur	PROPN
admet-1570	401	2	j	j	PROPN
admet-1570	401	3	clin	clin	PROPN
admet-1570	401	4	pharmacol	pharmacol	PROPN
admet-1570	401	5	65	65	NUM
admet-1570	401	6	(	(	PUNCT
admet-1570	401	7	2009	2009	NUM
admet-1570	401	8	)	)	PUNCT
admet-1570	401	9	1211	1211	NUM
admet-1570	401	10	-	-	SYM
admet-1570	401	11	1228	1228	NUM
admet-1570	401	12	.	.	PUNCT
admet-1570	402	1	https://doi.org/10.1007/s00228-009-0718-4	https://doi.org/10.1007/s00228-009-0718-4	NUM
admet-1570	402	2	.	.	PUNCT
admet-1570	403	1	[	[	X
admet-1570	403	2	3	3	X
admet-1570	403	3	]	]	X
admet-1570	403	4	w.l	w.l	PROPN
admet-1570	403	5	.	.	PROPN
admet-1570	403	6	beeken	beeken	VERB
admet-1570	403	7	,	,	PUNCT
admet-1570	403	8	w.	w.	NOUN
admet-1570	403	9	volwiler	volwiler	NOUN
admet-1570	403	10	,	,	PUNCT
admet-1570	403	11	p.d	p.d	PROPN
admet-1570	403	12	.	.	PROPN
admet-1570	403	13	goldsworthy	goldsworthy	PROPN
admet-1570	403	14	,	,	PUNCT
admet-1570	403	15	l.e	l.e	PROPN
admet-1570	403	16	.	.	PROPN
admet-1570	403	17	garby	garby	PROPN
admet-1570	403	18	,	,	PUNCT
admet-1570	403	19	w.e	w.e	PROPN
admet-1570	403	20	.	.	PROPN
admet-1570	403	21	reynolds	reynolds	PROPN
admet-1570	403	22	,	,	PUNCT
admet-1570	403	23	r.	r.	PROPN
admet-1570	403	24	stogsdill	stogsdill	PROPN
admet-1570	403	25	,	,	PUNCT
admet-1570	403	26	r.s	r.s	PROPN
admet-1570	403	27	.	.	PROPN
admet-1570	403	28	stemler	stemler	PROPN
admet-1570	403	29	.	.	PUNCT
admet-1570	404	1	studies	study	NOUN
admet-1570	404	2	of	of	ADP
admet-1570	404	3	i-131	i-131	PROPN
admet-1570	404	4	-	-	PUNCT
admet-1570	404	5	albumin	albumin	ADJ
admet-1570	404	6	catabolism	catabolism	NOUN
admet-1570	404	7	and	and	CCONJ
admet-1570	404	8	distribution	distribution	NOUN
admet-1570	404	9	in	in	ADP
admet-1570	404	10	normal	normal	ADJ
admet-1570	404	11	young	young	ADJ
admet-1570	404	12	male	male	ADJ
admet-1570	404	13	adults	adult	NOUN
admet-1570	404	14	.	.	PUNCT
admet-1570	405	1	j	j	PROPN
admet-1570	405	2	clin	clin	PROPN
admet-1570	405	3	invest	invest	VERB
admet-1570	405	4	41	41	NUM
admet-1570	405	5	(	(	PUNCT
admet-1570	405	6	1962	1962	NUM
admet-1570	405	7	)	)	PUNCT
admet-1570	405	8	1312	1312	NUM
admet-1570	405	9	-	-	SYM
admet-1570	405	10	1333	1333	NUM
admet-1570	405	11	.	.	PUNCT
admet-1570	406	1	https://doi.org/10.1172/jci104594	https://doi.org/10.1172/jci104594	NOUN
admet-1570	406	2	.	.	PUNCT
admet-1570	407	1	[	[	X
admet-1570	407	2	4	4	NUM
admet-1570	407	3	]	]	X
admet-1570	407	4	y.	y.	PROPN
admet-1570	407	5	takeda	takeda	PROPN
admet-1570	407	6	,	,	PUNCT
admet-1570	407	7	e.b	e.b	PROPN
admet-1570	407	8	.	.	PUNCT
admet-1570	407	9	reeve	reeve	PROPN
admet-1570	407	10	.	.	PUNCT
admet-1570	408	1	studies	study	NOUN
admet-1570	408	2	of	of	ADP
admet-1570	408	3	the	the	DET
admet-1570	408	4	metabolism	metabolism	NOUN
admet-1570	408	5	and	and	CCONJ
admet-1570	408	6	distribution	distribution	NOUN
admet-1570	408	7	of	of	ADP
admet-1570	408	8	albumin	albumin	NOUN
admet-1570	408	9	with	with	ADP
admet-1570	408	10	autologous	autologous	ADJ
admet-1570	408	11	i131albumin	i131albumin	NOUN
admet-1570	408	12	in	in	ADP
admet-1570	408	13	healthy	healthy	ADJ
admet-1570	408	14	men	man	NOUN
admet-1570	408	15	.	.	PUNCT
admet-1570	409	1	j	j	PROPN
admet-1570	409	2	lab	lab	PROPN
admet-1570	409	3	clin	clin	PROPN
admet-1570	409	4	med	me	VERB
admet-1570	409	5	61	61	NUM
admet-1570	409	6	(	(	PUNCT
admet-1570	409	7	1963	1963	NUM
admet-1570	409	8	)	)	PUNCT
admet-1570	409	9	183	183	NUM
admet-1570	409	10	-	-	SYM
admet-1570	409	11	202	202	NUM
admet-1570	409	12	.	.	PUNCT
admet-1570	410	1	https://www.ncbi.nlm.nih.gov/pubmed/13984638	https://www.ncbi.nlm.nih.gov/pubmed/13984638	X
admet-1570	410	2	.	.	PUNCT
admet-1570	411	1	[	[	X
admet-1570	411	2	5	5	NUM
admet-1570	411	3	]	]	X
admet-1570	411	4	r.h	r.h	PROPN
admet-1570	411	5	.	.	PROPN
admet-1570	411	6	rose	rise	VERB
admet-1570	411	7	,	,	PUNCT
admet-1570	411	8	a.	a.	NOUN
admet-1570	411	9	sepp	sepp	PROPN
admet-1570	411	10	,	,	PUNCT
admet-1570	411	11	f.	f.	PROPN
admet-1570	411	12	stader	stader	PROPN
admet-1570	411	13	,	,	PUNCT
admet-1570	411	14	k.l	k.l	PROPN
admet-1570	411	15	.	.	PROPN
admet-1570	411	16	gill	gill	PROPN
admet-1570	411	17	,	,	PUNCT
admet-1570	411	18	c.	c.	PROPN
admet-1570	411	19	liu	liu	PROPN
admet-1570	411	20	,	,	PUNCT
admet-1570	411	21	i.	i.	PROPN
admet-1570	411	22	gardner	gardner	PROPN
admet-1570	411	23	.	.	PUNCT
admet-1570	412	1	application	application	NOUN
admet-1570	412	2	of	of	ADP
admet-1570	412	3	physiologically	physiologically	ADV
admet-1570	412	4	-	-	PUNCT
admet-1570	412	5	based	base	VERB
admet-1570	412	6	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	412	7	models	model	NOUN
admet-1570	412	8	for	for	ADP
admet-1570	412	9	therapeutic	therapeutic	ADJ
admet-1570	412	10	proteins	protein	NOUN
admet-1570	412	11	and	and	CCONJ
admet-1570	412	12	other	other	ADJ
admet-1570	412	13	novel	novel	ADJ
admet-1570	412	14	modalities	modality	NOUN
admet-1570	412	15	.	.	PUNCT
admet-1570	413	1	xenobiotica	xenobiotica	PROPN
admet-1570	413	2	(	(	PUNCT
admet-1570	413	3	2022	2022	NUM
admet-1570	413	4	)	)	PUNCT
admet-1570	413	5	1	1	NUM
admet-1570	413	6	-	-	SYM
admet-1570	413	7	27	27	NUM
admet-1570	413	8	.	.	PUNCT
admet-1570	414	1	https://doi.org/10.1080/00498254.2022.2133649	https://doi.org/10.1080/00498254.2022.2133649	NOUN
admet-1570	414	2	.	.	PUNCT
admet-1570	415	1	[	[	X
admet-1570	415	2	6	6	NUM
admet-1570	415	3	]	]	X
admet-1570	415	4	d.k	d.k	PROPN
admet-1570	415	5	.	.	PROPN
admet-1570	415	6	shah	shah	PROPN
admet-1570	415	7	,	,	PUNCT
admet-1570	415	8	a.m.	a.m.	PROPN
admet-1570	415	9	betts	betts	PROPN
admet-1570	415	10	.	.	PROPN
admet-1570	415	11	towards	towards	ADP
admet-1570	415	12	a	a	DET
admet-1570	415	13	platform	platform	NOUN
admet-1570	415	14	pbpk	pbpk	NOUN
admet-1570	415	15	model	model	NOUN
admet-1570	415	16	to	to	PART
admet-1570	415	17	characterize	characterize	VERB
admet-1570	415	18	the	the	DET
admet-1570	415	19	plasma	plasma	NOUN
admet-1570	415	20	and	and	CCONJ
admet-1570	415	21	tissue	tissue	NOUN
admet-1570	415	22	disposition	disposition	NOUN
admet-1570	415	23	of	of	ADP
admet-1570	415	24	monoclonal	monoclonal	NOUN
admet-1570	415	25	antibodies	antibody	NOUN
admet-1570	415	26	in	in	ADP
admet-1570	415	27	preclinical	preclinical	ADJ
admet-1570	415	28	species	specie	NOUN
admet-1570	415	29	and	and	CCONJ
admet-1570	415	30	human	human	NOUN
admet-1570	415	31	.	.	PUNCT
admet-1570	416	1	j	j	PROPN
admet-1570	416	2	pharmacokinet	pharmacokinet	PROPN
admet-1570	416	3	pharmacodyn	pharmacodyn	ADV
admet-1570	416	4	39	39	NUM
admet-1570	416	5	(	(	PUNCT
admet-1570	416	6	2012	2012	NUM
admet-1570	416	7	)	)	PUNCT
admet-1570	416	8	67	67	NUM
admet-1570	416	9	-	-	SYM
admet-1570	416	10	86	86	NUM
admet-1570	416	11	.	.	PUNCT
admet-1570	417	1	https://doi.org/10.1007/s10928-011-9232-2	https://doi.org/10.1007/s10928-011-9232-2	X
admet-1570	417	2	.	.	PUNCT
admet-1570	418	1	[	[	X
admet-1570	418	2	7	7	X
admet-1570	418	3	]	]	X
admet-1570	418	4	h.	h.	PROPN
admet-1570	418	5	wong	wong	PROPN
admet-1570	418	6	,	,	PUNCT
admet-1570	418	7	t.w	t.w	PROPN
admet-1570	418	8	.	.	PROPN
admet-1570	418	9	chow	chow	PROPN
admet-1570	418	10	.	.	PUNCT
admet-1570	419	1	physiologically	physiologically	ADV
admet-1570	419	2	based	base	VERB
admet-1570	419	3	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	419	4	modeling	modeling	NOUN
admet-1570	419	5	of	of	ADP
admet-1570	419	6	therapeutic	therapeutic	ADJ
admet-1570	419	7	proteins	protein	NOUN
admet-1570	419	8	.	.	PUNCT
admet-1570	420	1	j	j	PROPN
admet-1570	420	2	pharm	pharm	PROPN
admet-1570	420	3	sci	sci	PROPN
admet-1570	420	4	106	106	NUM
admet-1570	420	5	(	(	PUNCT
admet-1570	420	6	2017	2017	NUM
admet-1570	420	7	)	)	PUNCT
admet-1570	420	8	2270	2270	NUM
admet-1570	420	9	-	-	SYM
admet-1570	420	10	2275	2275	NUM
admet-1570	420	11	.	.	PUNCT
admet-1570	421	1	https://doi.org/10.1016/j.xphs.2017.03.038	https://doi.org/10.1016/j.xphs.2017.03.038	X
admet-1570	421	2	.	.	PUNCT
admet-1570	422	1	[	[	X
admet-1570	422	2	8	8	NUM
admet-1570	422	3	]	]	SYM
admet-1570	422	4	p.m.	p.m.	NOUN
admet-1570	422	5	glassman	glassman	PROPN
admet-1570	422	6	,	,	PUNCT
admet-1570	422	7	j.p	j.p	PROPN
admet-1570	422	8	.	.	PROPN
admet-1570	422	9	balthasar	balthasar	PROPN
admet-1570	422	10	.	.	PUNCT
admet-1570	423	1	physiologically	physiologically	ADV
admet-1570	423	2	-	-	PUNCT
admet-1570	423	3	based	base	VERB
admet-1570	423	4	modeling	modeling	NOUN
admet-1570	423	5	of	of	ADP
admet-1570	423	6	monoclonal	monoclonal	NOUN
admet-1570	423	7	antibody	antibody	NOUN
admet-1570	423	8	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	423	9	in	in	ADP
admet-1570	423	10	drug	drug	NOUN
admet-1570	423	11	discovery	discovery	NOUN
admet-1570	423	12	and	and	CCONJ
admet-1570	423	13	development	development	NOUN
admet-1570	423	14	.	.	PUNCT
admet-1570	424	1	drug	drug	NOUN
admet-1570	424	2	metab	metab	PROPN
admet-1570	424	3	pharmacokinet	pharmacokinet	NOUN
admet-1570	424	4	34	34	NUM
admet-1570	424	5	(	(	PUNCT
admet-1570	424	6	2019	2019	NUM
admet-1570	424	7	)	)	PUNCT
admet-1570	424	8	3	3	NUM
admet-1570	424	9	-	-	SYM
admet-1570	424	10	13	13	NUM
admet-1570	424	11	.	.	PUNCT
admet-1570	424	12	https://doi.org/10.1016/j.dmpk.2018.11.002	https://doi.org/10.1016/j.dmpk.2018.11.002	NOUN
admet-1570	424	13	.	.	PUNCT
admet-1570	425	1	[	[	X
admet-1570	425	2	9	9	NUM
admet-1570	425	3	]	]	PUNCT
admet-1570	425	4	j.	j.	PROPN
admet-1570	425	5	lindena	lindena	PROPN
admet-1570	425	6	,	,	PUNCT
admet-1570	425	7	f.	f.	PROPN
admet-1570	425	8	diederichs	diederichs	PROPN
admet-1570	425	9	,	,	PUNCT
admet-1570	425	10	h.	h.	PROPN
admet-1570	425	11	wittenberg	wittenberg	PROPN
admet-1570	425	12	,	,	PUNCT
admet-1570	425	13	i.	i.	PROPN
admet-1570	425	14	trautschold	trautschold	PROPN
admet-1570	425	15	.	.	PUNCT
admet-1570	426	1	kinetic	kinetic	NOUN
admet-1570	426	2	of	of	ADP
admet-1570	426	3	adjustment	adjustment	NOUN
admet-1570	426	4	of	of	ADP
admet-1570	426	5	enzyme	enzyme	NOUN
admet-1570	426	6	catalytic	catalytic	ADJ
admet-1570	426	7	concentrations	concentration	NOUN
admet-1570	426	8	in	in	ADP
admet-1570	426	9	the	the	DET
admet-1570	426	10	extracellular	extracellular	ADJ
admet-1570	426	11	space	space	NOUN
admet-1570	426	12	of	of	ADP
admet-1570	426	13	the	the	DET
admet-1570	426	14	man	man	NOUN
admet-1570	426	15	,	,	PUNCT
admet-1570	426	16	the	the	DET
admet-1570	426	17	dog	dog	NOUN
admet-1570	426	18	and	and	CCONJ
admet-1570	426	19	the	the	DET
admet-1570	426	20	rat	rat	NOUN
admet-1570	426	21	.	.	PROPN
admet-1570	426	22	approach	approach	NOUN
admet-1570	426	23	to	to	ADP
admet-1570	426	24	a	a	DET
admet-1570	426	25	quantitative	quantitative	ADJ
admet-1570	426	26	diagnostic	diagnostic	ADJ
admet-1570	426	27	enzymology	enzymology	NOUN
admet-1570	426	28	,	,	PUNCT
admet-1570	426	29	v.	v.	ADP
admet-1570	426	30	communication	communication	NOUN
admet-1570	426	31	.	.	PUNCT
admet-1570	427	1	j	j	PROPN
admet-1570	427	2	clin	clin	PROPN
admet-1570	427	3	chem	chem	PROPN
admet-1570	427	4	clin	clin	PROPN
admet-1570	427	5	biochem	biochem	PROPN
admet-1570	427	6	24	24	NUM
admet-1570	427	7	(	(	PUNCT
admet-1570	427	8	1986	1986	NUM
admet-1570	427	9	)	)	PUNCT
admet-1570	427	10	61	61	NUM
admet-1570	427	11	-	-	SYM
admet-1570	427	12	71	71	NUM
admet-1570	427	13	.	.	PUNCT
admet-1570	427	14	https://doi.org/10.1515/cclm.1986.24.1.61	https://doi.org/10.1515/cclm.1986.24.1.61	NOUN
admet-1570	427	15	.	.	PUNCT
admet-1570	428	1	[	[	X
admet-1570	428	2	10	10	NUM
admet-1570	428	3	]	]	PUNCT
admet-1570	428	4	b.	b.	PROPN
admet-1570	428	5	rippe	rippe	PROPN
admet-1570	428	6	,	,	PUNCT
admet-1570	428	7	b.i	b.i	PROPN
admet-1570	428	8	.	.	PROPN
admet-1570	428	9	rosengren	rosengren	PROPN
admet-1570	428	10	,	,	PUNCT
admet-1570	428	11	o.	o.	PROPN
admet-1570	428	12	carlsson	carlsson	PROPN
admet-1570	428	13	,	,	PUNCT
admet-1570	428	14	d.	d.	PROPN
admet-1570	428	15	venturoli	venturoli	PROPN
admet-1570	428	16	.	.	PUNCT
admet-1570	429	1	transendothelial	transendothelial	ADJ
admet-1570	429	2	transport	transport	NOUN
admet-1570	429	3	:	:	PUNCT
admet-1570	429	4	the	the	DET
admet-1570	429	5	vesicle	vesicle	NOUN
admet-1570	429	6	controversy	controversy	NOUN
admet-1570	429	7	.	.	PUNCT
admet-1570	430	1	j	j	PROPN
admet-1570	430	2	vasc	vasc	PROPN
admet-1570	430	3	res	res	PROPN
admet-1570	430	4	39	39	NUM
admet-1570	430	5	(	(	PUNCT
admet-1570	430	6	2002	2002	NUM
admet-1570	430	7	)	)	PUNCT
admet-1570	430	8	375	375	NUM
admet-1570	430	9	-	-	SYM
admet-1570	430	10	390	390	NUM
admet-1570	430	11	.	.	PUNCT
admet-1570	431	1	https://doi.org/10.1159/000064521	https://doi.org/10.1159/000064521	NOUN
admet-1570	431	2	.	.	PUNCT
admet-1570	432	1	[	[	X
admet-1570	432	2	11	11	NUM
admet-1570	432	3	]	]	X
admet-1570	432	4	b.i	b.i	PROPN
admet-1570	432	5	.	.	PROPN
admet-1570	432	6	rosengren	rosengren	PROPN
admet-1570	432	7	,	,	PUNCT
admet-1570	432	8	a.	a.	NOUN
admet-1570	432	9	rippe	rippe	PROPN
admet-1570	432	10	,	,	PUNCT
admet-1570	432	11	c.	c.	PROPN
admet-1570	432	12	rippe	rippe	PROPN
admet-1570	432	13	,	,	PUNCT
admet-1570	432	14	d.	d.	PROPN
admet-1570	432	15	venturoli	venturoli	PROPN
admet-1570	432	16	,	,	PUNCT
admet-1570	432	17	k.	k.	PROPN
admet-1570	432	18	sward	sward	PROPN
admet-1570	432	19	,	,	PUNCT
admet-1570	432	20	b.	b.	PROPN
admet-1570	432	21	rippe	rippe	PROPN
admet-1570	432	22	.	.	PUNCT
admet-1570	433	1	transvascular	transvascular	ADJ
admet-1570	433	2	protein	protein	NOUN
admet-1570	433	3	transport	transport	NOUN
admet-1570	433	4	in	in	ADP
admet-1570	433	5	mice	mouse	NOUN
admet-1570	433	6	lacking	lack	VERB
admet-1570	433	7	endothelial	endothelial	ADJ
admet-1570	433	8	caveolae	caveolae	NOUN
admet-1570	433	9	.	.	PUNCT
admet-1570	434	1	am	be	AUX
admet-1570	434	2	j	j	PROPN
admet-1570	434	3	physiol	physiol	PROPN
admet-1570	434	4	heart	heart	PROPN
admet-1570	434	5	circ	circ	PROPN
admet-1570	434	6	physiol	physiol	PROPN
admet-1570	434	7	291	291	NUM
admet-1570	434	8	(	(	PUNCT
admet-1570	434	9	2006	2006	NUM
admet-1570	434	10	)	)	PUNCT
admet-1570	434	11	h1371	h1371	PROPN
admet-1570	434	12	-	-	NOUN
admet-1570	434	13	1377	1377	NUM
admet-1570	434	14	.	.	PUNCT
admet-1570	435	1	https://doi.org/10.1152/ajpheart.01364.2005	https://doi.org/10.1152/ajpheart.01364.2005	PROPN
admet-1570	435	2	.	.	PUNCT
admet-1570	436	1	[	[	X
admet-1570	436	2	12	12	NUM
admet-1570	436	3	]	]	PUNCT
admet-1570	436	4	b.	b.	PROPN
admet-1570	436	5	rippe	rippe	PROPN
admet-1570	436	6	,	,	PUNCT
admet-1570	436	7	b.	b.	PROPN
admet-1570	436	8	haraldsson	haraldsson	PROPN
admet-1570	436	9	.	.	PUNCT
admet-1570	437	1	fluid	fluid	NOUN
admet-1570	437	2	and	and	CCONJ
admet-1570	437	3	protein	protein	NOUN
admet-1570	437	4	fluxes	flux	NOUN
admet-1570	437	5	across	across	ADP
admet-1570	437	6	small	small	ADJ
admet-1570	437	7	and	and	CCONJ
admet-1570	437	8	large	large	ADJ
admet-1570	437	9	pores	pore	NOUN
admet-1570	437	10	in	in	ADP
admet-1570	437	11	the	the	DET
admet-1570	437	12	microvasculature	microvasculature	NOUN
admet-1570	437	13	.	.	PUNCT
admet-1570	438	1	application	application	NOUN
admet-1570	438	2	of	of	ADP
admet-1570	438	3	two	two	NUM
admet-1570	438	4	-	-	PUNCT
admet-1570	438	5	pore	pore	ADJ
admet-1570	438	6	equations	equation	NOUN
admet-1570	438	7	.	.	PUNCT
admet-1570	439	1	acta	acta	PROPN
admet-1570	439	2	physiol	physiol	PROPN
admet-1570	439	3	scand	scand	PROPN
admet-1570	439	4	131	131	NUM
admet-1570	439	5	(	(	PUNCT
admet-1570	439	6	1987	1987	NUM
admet-1570	439	7	)	)	PUNCT
admet-1570	439	8	411	411	NUM
admet-1570	439	9	-	-	SYM
admet-1570	439	10	428	428	NUM
admet-1570	439	11	.	.	PUNCT
admet-1570	440	1	https://doi.org/10.1111/j.1748-1716.1987.tb08257.x	https://doi.org/10.1111/j.1748-1716.1987.tb08257.x	X
admet-1570	440	2	.	.	PUNCT
admet-1570	441	1	[	[	X
admet-1570	441	2	13	13	NUM
admet-1570	441	3	]	]	PUNCT
admet-1570	441	4	a.	a.	NOUN
admet-1570	441	5	bill	bill	NOUN
admet-1570	441	6	.	.	PUNCT
admet-1570	442	1	plasma	plasma	NOUN
admet-1570	442	2	protein	protein	NOUN
admet-1570	442	3	dynamics	dynamic	NOUN
admet-1570	442	4	:	:	PUNCT
admet-1570	442	5	albumin	albumin	NOUN
admet-1570	442	6	and	and	CCONJ
admet-1570	442	7	igg	igg	PROPN
admet-1570	442	8	capillary	capillary	ADJ
admet-1570	442	9	permeability	permeability	NOUN
admet-1570	442	10	,	,	PUNCT
admet-1570	442	11	extravascular	extravascular	ADJ
admet-1570	442	12	movement	movement	NOUN
admet-1570	442	13	and	and	CCONJ
admet-1570	442	14	regional	regional	ADJ
admet-1570	442	15	blood	blood	NOUN
admet-1570	442	16	flow	flow	NOUN
admet-1570	442	17	in	in	ADP
admet-1570	442	18	unanesthetized	unanesthetized	ADJ
admet-1570	442	19	rabbits	rabbit	NOUN
admet-1570	442	20	.	.	PUNCT
admet-1570	443	1	acta	acta	PROPN
admet-1570	443	2	physiol	physiol	PROPN
admet-1570	443	3	scand	scand	PROPN
admet-1570	443	4	101	101	NUM
admet-1570	443	5	(	(	PUNCT
admet-1570	443	6	1977	1977	NUM
admet-1570	443	7	)	)	PUNCT
admet-1570	443	8	28	28	NUM
admet-1570	443	9	-	-	SYM
admet-1570	443	10	42	42	NUM
admet-1570	443	11	.	.	PUNCT
admet-1570	444	1	https://doi.org/10.1111/j.1748-1716.1977.tb05980.x	https://doi.org/10.1111/j.1748-1716.1977.tb05980.x	NOUN
admet-1570	444	2	.	.	PUNCT
admet-1570	445	1	[	[	X
admet-1570	445	2	14	14	NUM
admet-1570	445	3	]	]	X
admet-1570	445	4	m.	m.	PROPN
admet-1570	445	5	perry	perry	PROPN
admet-1570	445	6	,	,	PUNCT
admet-1570	445	7	d.	d.	PROPN
admet-1570	445	8	garlick	garlick	PROPN
admet-1570	445	9	.	.	PUNCT
admet-1570	446	1	transcapillary	transcapillary	ADJ
admet-1570	446	2	efflux	efflux	NOUN
admet-1570	446	3	of	of	ADP
admet-1570	446	4	gamma	gamma	PROPN
admet-1570	446	5	globulin	globulin	NOUN
admet-1570	446	6	in	in	ADP
admet-1570	446	7	rabbit	rabbit	NOUN
admet-1570	446	8	skeletal	skeletal	ADJ
admet-1570	446	9	muscle	muscle	NOUN
admet-1570	446	10	.	.	PUNCT
admet-1570	447	1	microvasc	microvasc	PROPN
admet-1570	447	2	res	re	NOUN
admet-1570	447	3	9	9	NUM
admet-1570	447	4	(	(	PUNCT
admet-1570	447	5	1975	1975	NUM
admet-1570	447	6	)	)	PUNCT
admet-1570	447	7	119	119	NUM
admet-1570	447	8	-	-	SYM
admet-1570	447	9	126	126	NUM
admet-1570	447	10	.	.	PUNCT
admet-1570	448	1	https://doi.org/10.1016/0026-2862(75)90056-4	https://doi.org/10.1016/0026-2862(75)90056-4	PROPN
admet-1570	448	2	.	.	PUNCT
admet-1570	449	1	[	[	X
admet-1570	449	2	15	15	NUM
admet-1570	449	3	]	]	X
admet-1570	449	4	n.a	n.a	PROPN
admet-1570	449	5	.	.	PROPN
admet-1570	449	6	lassen	lassen	PROPN
admet-1570	449	7	,	,	PUNCT
admet-1570	449	8	h.h	h.h	PROPN
admet-1570	449	9	.	.	PROPN
admet-1570	449	10	parving	parving	NOUN
admet-1570	449	11	,	,	PUNCT
admet-1570	449	12	n.	n.	PROPN
admet-1570	449	13	rossing	rossing	NOUN
admet-1570	449	14	.	.	PUNCT
admet-1570	450	1	editorial	editorial	NOUN
admet-1570	450	2	:	:	PUNCT
admet-1570	450	3	filtration	filtration	NOUN
admet-1570	450	4	as	as	ADP
admet-1570	450	5	the	the	DET
admet-1570	450	6	main	main	ADJ
admet-1570	450	7	mechanism	mechanism	NOUN
admet-1570	450	8	of	of	ADP
admet-1570	450	9	overall	overall	ADJ
admet-1570	450	10	transcapillary	transcapillary	ADJ
admet-1570	450	11	protein	protein	NOUN
admet-1570	450	12	escape	escape	NOUN
admet-1570	450	13	from	from	ADP
admet-1570	450	14	the	the	DET
admet-1570	450	15	plasma	plasma	NOUN
admet-1570	450	16	.	.	PUNCT
admet-1570	451	1	microvascular	microvascular	ADJ
admet-1570	451	2	research	research	NOUN
admet-1570	451	3	7	7	NUM
admet-1570	451	4	(	(	PUNCT
admet-1570	451	5	1974	1974	NUM
admet-1570	451	6	)	)	PUNCT
admet-1570	451	7	i	i	PROPN
admet-1570	451	8	-	-	PUNCT
admet-1570	451	9	iv	iv	NOUN
admet-1570	451	10	.	.	PUNCT
admet-1570	452	1	[	[	X
admet-1570	452	2	16	16	NUM
admet-1570	452	3	]	]	PUNCT
admet-1570	452	4	j.	j.	PROPN
admet-1570	452	5	zhao	zhao	PROPN
admet-1570	452	6	,	,	PUNCT
admet-1570	452	7	y.	y.	PROPN
admet-1570	452	8	cao	cao	PROPN
admet-1570	452	9	,	,	PUNCT
admet-1570	452	10	w.j	w.j	PROPN
admet-1570	452	11	.	.	PROPN
admet-1570	452	12	jusko	jusko	PROPN
admet-1570	452	13	.	.	PUNCT
admet-1570	453	1	across	across	ADP
admet-1570	453	2	-	-	PUNCT
admet-1570	453	3	species	species	NOUN
admet-1570	453	4	scaling	scaling	NOUN
admet-1570	453	5	of	of	ADP
admet-1570	453	6	monoclonal	monoclonal	NOUN
admet-1570	453	7	antibody	antibody	NOUN
admet-1570	453	8	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	453	9	using	use	VERB
admet-1570	453	10	a	a	DET
admet-1570	453	11	minimal	minimal	ADJ
admet-1570	453	12	pbpk	pbpk	ADJ
admet-1570	453	13	model	model	NOUN
admet-1570	453	14	.	.	PUNCT
admet-1570	454	1	pharm	pharm	NOUN
admet-1570	454	2	res	re	VERB
admet-1570	454	3	32	32	NUM
admet-1570	454	4	(	(	PUNCT
admet-1570	454	5	2015	2015	NUM
admet-1570	454	6	)	)	PUNCT
admet-1570	454	7	3269	3269	NUM
admet-1570	454	8	-	-	PUNCT
admet-1570	454	9	3281	3281	NUM
admet-1570	454	10	.	.	PUNCT
admet-1570	455	1	https://doi.org/10.1007/s11095-015-1703-5	https://doi.org/10.1007/s11095-015-1703-5	NUM
admet-1570	455	2	.	.	PUNCT
admet-1570	455	3	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	456	1	https://doi.org/10.1097/mib.0000000000001043	https://doi.org/10.1097/mib.0000000000001043	PROPN
admet-1570	456	2	https://doi.org/10.1097/mib.0000000000001043	https://doi.org/10.1097/mib.0000000000001043	PROPN
admet-1570	456	3	https://doi.org/10.1007/s00228-009-0718-4	https://doi.org/10.1007/s00228-009-0718-4	NUM
admet-1570	456	4	https://doi.org/10.1172/jci104594	https://doi.org/10.1172/jci104594	NOUN
admet-1570	456	5	https://www.ncbi.nlm.nih.gov/pubmed/13984638	https://www.ncbi.nlm.nih.gov/pubmed/13984638	PRON
admet-1570	456	6	https://www.ncbi.nlm.nih.gov/pubmed/13984638	https://www.ncbi.nlm.nih.gov/pubmed/13984638	NUM
admet-1570	456	7	https://doi.org/10.1080/00498254.2022.2133649	https://doi.org/10.1080/00498254.2022.2133649	NOUN
admet-1570	456	8	https://doi.org/10.1007/s10928-011-9232-2	https://doi.org/10.1007/s10928-011-9232-2	NUM
admet-1570	456	9	https://doi.org/10.1016/j.xphs.2017.03.038	https://doi.org/10.1016/j.xphs.2017.03.038	NUM
admet-1570	456	10	https://doi.org/10.1016/j.dmpk.2018.11.002	https://doi.org/10.1016/j.dmpk.2018.11.002	NOUN
admet-1570	456	11	https://doi.org/10.1515/cclm.1986.24.1.61	https://doi.org/10.1515/cclm.1986.24.1.61	NOUN
admet-1570	456	12	https://doi.org/10.1515/cclm.1986.24.1.61	https://doi.org/10.1515/cclm.1986.24.1.61	NOUN
admet-1570	456	13	https://doi.org/10.1159/000064521	https://doi.org/10.1159/000064521	NOUN
admet-1570	456	14	https://doi.org/10.1152/ajpheart.01364.2005	https://doi.org/10.1152/ajpheart.01364.2005	PROPN
admet-1570	456	15	https://doi.org/10.1111/j.1748-1716.1987.tb08257.x	https://doi.org/10.1111/j.1748-1716.1987.tb08257.x	NOUN
admet-1570	457	1	https://doi.org/10.1111/j.1748-1716.1987.tb08257.x	https://doi.org/10.1111/j.1748-1716.1987.tb08257.x	PROPN
admet-1570	457	2	https://doi.org/10.1111/j.1748-1716.1977.tb05980.x	https://doi.org/10.1111/j.1748-1716.1977.tb05980.x	PROPN
admet-1570	457	3	https://doi.org/10.1111/j.1748-1716.1977.tb05980.x	https://doi.org/10.1111/j.1748-1716.1977.tb05980.x	PROPN
admet-1570	457	4	https://doi.org/10.1016/0026-2862(75)90056-4	https://doi.org/10.1016/0026-2862(75)90056-4	PROPN
admet-1570	457	5	https://doi.org/10.1007/s11095-015-1703-5	https://doi.org/10.1007/s11095-015-1703-5	NUM
admet-1570	458	1	d.g	d.g	PROPN
admet-1570	458	2	.	.	PROPN
admet-1570	458	3	levitt	levitt	PROPN
admet-1570	458	4	and	and	CCONJ
admet-1570	458	5	m.d	m.d	PROPN
admet-1570	458	6	.	.	PROPN
admet-1570	458	7	levitt	levitt	PROPN
admet-1570	458	8	admet	admet	PROPN
admet-1570	458	9	&	&	CCONJ
admet-1570	458	10	dmpk	dmpk	PROPN
admet-1570	458	11	11(1	11(1	NUM
admet-1570	458	12	)	)	PUNCT
admet-1570	458	13	(	(	PUNCT
admet-1570	458	14	2023	2023	NUM
admet-1570	458	15	)	)	PUNCT
admet-1570	458	16	57	57	NUM
admet-1570	458	17	-	-	SYM
admet-1570	458	18	80	80	NUM
admet-1570	458	19	78	78	NUM
admet-1570	459	1	[	[	X
admet-1570	459	2	17	17	NUM
admet-1570	459	3	]	]	X
admet-1570	459	4	d.g	d.g	PROPN
admet-1570	459	5	.	.	PROPN
admet-1570	459	6	levitt	levitt	PROPN
admet-1570	459	7	.	.	PUNCT
admet-1570	460	1	the	the	DET
admet-1570	460	2	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	460	3	of	of	ADP
admet-1570	460	4	the	the	DET
admet-1570	460	5	interstitial	interstitial	ADJ
admet-1570	460	6	space	space	NOUN
admet-1570	460	7	in	in	ADP
admet-1570	460	8	humans	human	NOUN
admet-1570	460	9	.	.	PUNCT
admet-1570	461	1	bmc	bmc	PROPN
admet-1570	461	2	clin	clin	PROPN
admet-1570	461	3	pharmacol	pharmacol	PROPN
admet-1570	461	4	3	3	NUM
admet-1570	461	5	(	(	PUNCT
admet-1570	461	6	2003	2003	NUM
admet-1570	461	7	)	)	PUNCT
admet-1570	461	8	3	3	NUM
admet-1570	461	9	.	.	PUNCT
admet-1570	461	10	https://doi.org/10.1186/1472-6904-3-3	https://doi.org/10.1186/1472-6904-3-3	PROPN
admet-1570	461	11	.	.	PUNCT
admet-1570	462	1	[	[	X
admet-1570	462	2	18	18	NUM
admet-1570	462	3	]	]	X
admet-1570	462	4	d.g	d.g	PROPN
admet-1570	462	5	.	.	PROPN
admet-1570	462	6	levitt	levitt	PROPN
admet-1570	462	7	,	,	PUNCT
admet-1570	462	8	computer	computer	NOUN
admet-1570	462	9	assisted	assist	VERB
admet-1570	462	10	human	human	ADJ
admet-1570	462	11	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	462	12	:	:	PUNCT
admet-1570	462	13	non	non	ADJ
admet-1570	462	14	-	-	ADJ
admet-1570	462	15	compartmental	compartmental	ADJ
admet-1570	462	16	,	,	PUNCT
admet-1570	462	17	deconvolution	deconvolution	NOUN
admet-1570	462	18	,	,	PUNCT
admet-1570	462	19	physiologically	physiologically	ADV
admet-1570	462	20	based	base	VERB
admet-1570	462	21	,	,	PUNCT
admet-1570	462	22	intestinal	intestinal	ADJ
admet-1570	462	23	absorption	absorption	NOUN
admet-1570	462	24	,	,	PUNCT
admet-1570	462	25	non	non	ADJ
admet-1570	462	26	-	-	ADJ
admet-1570	462	27	linear	linear	ADJ
admet-1570	462	28	,	,	PUNCT
admet-1570	462	29	www.pkquest.com	www.pkquest.com	PROPN
admet-1570	462	30	,	,	PUNCT
admet-1570	462	31	2017	2017	NUM
admet-1570	462	32	.	.	PUNCT
admet-1570	463	1	[	[	X
admet-1570	463	2	19	19	NUM
admet-1570	463	3	]	]	X
admet-1570	463	4	d.g	d.g	PROPN
admet-1570	463	5	.	.	PROPN
admet-1570	463	6	levitt	levitt	PROPN
admet-1570	463	7	.	.	PUNCT
admet-1570	464	1	pkquest	pkquest	PROPN
admet-1570	464	2	:	:	PUNCT
admet-1570	465	1	pbpk	pbpk	NOUN
admet-1570	465	2	modeling	modeling	NOUN
admet-1570	465	3	of	of	ADP
admet-1570	465	4	highly	highly	ADV
admet-1570	465	5	lipid	lipid	ADJ
admet-1570	465	6	soluble	soluble	ADJ
admet-1570	465	7	and	and	CCONJ
admet-1570	465	8	extracellular	extracellular	ADJ
admet-1570	465	9	solutes	solute	NOUN
admet-1570	465	10	.	.	PUNCT
admet-1570	466	1	admet	admet	PROPN
admet-1570	466	2	dmpk	dmpk	VERB
admet-1570	466	3	7	7	NUM
admet-1570	466	4	(	(	PUNCT
admet-1570	466	5	2019	2019	NUM
admet-1570	466	6	)	)	PUNCT
admet-1570	466	7	60	60	NUM
admet-1570	466	8	-	-	SYM
admet-1570	466	9	75	75	NUM
admet-1570	466	10	.	.	PUNCT
admet-1570	467	1	https://doi.org/10.5599/admet.579	https://doi.org/10.5599/admet.579	NOUN
admet-1570	467	2	.	.	PUNCT
admet-1570	468	1	[	[	X
admet-1570	468	2	20	20	NUM
admet-1570	468	3	]	]	X
admet-1570	468	4	c.a	c.a	PROPN
admet-1570	468	5	.	.	PROPN
admet-1570	468	6	goresky	goresky	PROPN
admet-1570	468	7	.	.	PUNCT
admet-1570	469	1	the	the	DET
admet-1570	469	2	processes	process	NOUN
admet-1570	469	3	of	of	ADP
admet-1570	469	4	cellular	cellular	ADJ
admet-1570	469	5	uptake	uptake	NOUN
admet-1570	469	6	and	and	CCONJ
admet-1570	469	7	exchange	exchange	NOUN
admet-1570	469	8	in	in	ADP
admet-1570	469	9	the	the	DET
admet-1570	469	10	liver	liver	NOUN
admet-1570	469	11	.	.	PUNCT
admet-1570	470	1	fed	fed	PROPN
admet-1570	470	2	proc	proc	NOUN
admet-1570	470	3	41	41	NUM
admet-1570	470	4	(	(	PUNCT
admet-1570	470	5	1982	1982	NUM
admet-1570	470	6	)	)	PUNCT
admet-1570	470	7	3033	3033	NUM
admet-1570	470	8	-	-	SYM
admet-1570	470	9	3039	3039	NUM
admet-1570	470	10	.	.	PUNCT
admet-1570	471	1	https://www.ncbi.nlm.nih.gov/pubmed/6754456	https://www.ncbi.nlm.nih.gov/pubmed/6754456	NOUN
admet-1570	471	2	.	.	PUNCT
admet-1570	472	1	[	[	X
admet-1570	472	2	21	21	NUM
admet-1570	472	3	]	]	X
admet-1570	472	4	j.c	j.c	PROPN
admet-1570	472	5	.	.	PROPN
admet-1570	472	6	cain	cain	PROPN
admet-1570	472	7	,	,	PUNCT
admet-1570	472	8	j.h	j.h	PROPN
admet-1570	472	9	.	.	PROPN
admet-1570	472	10	grindlay	grindlay	PROPN
admet-1570	472	11	,	,	PUNCT
admet-1570	472	12	et	et	PROPN
admet-1570	472	13	al	al	PROPN
admet-1570	472	14	.	.	PROPN
admet-1570	472	15	lymph	lymph	NOUN
admet-1570	472	16	from	from	ADP
admet-1570	472	17	liver	liver	NOUN
admet-1570	472	18	and	and	CCONJ
admet-1570	472	19	thoracic	thoracic	NOUN
admet-1570	472	20	duct	duct	NOUN
admet-1570	472	21	;	;	PUNCT
admet-1570	472	22	an	an	DET
admet-1570	472	23	experimental	experimental	ADJ
admet-1570	472	24	study	study	NOUN
admet-1570	472	25	.	.	PUNCT
admet-1570	473	1	surg	surg	PROPN
admet-1570	473	2	gynecol	gynecol	VERB
admet-1570	473	3	obstet	obstet	NOUN
admet-1570	473	4	85	85	NUM
admet-1570	473	5	(	(	PUNCT
admet-1570	473	6	1947	1947	NUM
admet-1570	473	7	)	)	PUNCT
admet-1570	473	8	558	558	NUM
admet-1570	473	9	-	-	SYM
admet-1570	473	10	562	562	NUM
admet-1570	473	11	.	.	PUNCT
admet-1570	474	1	https://www.ncbi.nlm.nih.gov/pubmed/20266768	https://www.ncbi.nlm.nih.gov/pubmed/20266768	NOUN
admet-1570	474	2	.	.	PUNCT
admet-1570	475	1	[	[	X
admet-1570	475	2	22	22	NUM
admet-1570	475	3	]	]	X
admet-1570	475	4	r.e	r.e	PROPN
admet-1570	475	5	.	.	PROPN
admet-1570	475	6	girardet	girardet	PROPN
admet-1570	475	7	,	,	PUNCT
admet-1570	475	8	d.l	d.l	PROPN
admet-1570	475	9	.	.	PROPN
admet-1570	475	10	benninghoff	benninghoff	PROPN
admet-1570	475	11	.	.	PUNCT
admet-1570	476	1	thoracic	thoracic	NOUN
admet-1570	476	2	duct	duct	NOUN
admet-1570	476	3	lymph	lymph	NOUN
admet-1570	476	4	and	and	CCONJ
admet-1570	476	5	lymphocyte	lymphocyte	ADJ
admet-1570	476	6	studies	study	NOUN
admet-1570	476	7	in	in	ADP
admet-1570	476	8	man	man	NOUN
admet-1570	476	9	using	use	VERB
admet-1570	476	10	a	a	DET
admet-1570	476	11	thoracic	thoracic	NOUN
admet-1570	476	12	duct	duct	NOUN
admet-1570	476	13	"	"	PUNCT
admet-1570	476	14	side	side	NOUN
admet-1570	476	15	-	-	PUNCT
admet-1570	476	16	fistula	fistula	NOUN
admet-1570	476	17	"	"	PUNCT
admet-1570	476	18	.	.	PUNCT
admet-1570	477	1	cancer	cancer	NOUN
admet-1570	477	2	29	29	NUM
admet-1570	477	3	(	(	PUNCT
admet-1570	477	4	1972	1972	NUM
admet-1570	477	5	)	)	PUNCT
admet-1570	477	6	666	666	NUM
admet-1570	477	7	-	-	PUNCT
admet-1570	477	8	669	669	NUM
admet-1570	477	9	.	.	PUNCT
admet-1570	478	1	https://doi.org/10.1002/1097-0142(197203)29:3	https://doi.org/10.1002/1097-0142(197203)29:3	PRON
admet-1570	479	1	[	[	X
admet-1570	479	2	23	23	NUM
admet-1570	479	3	]	]	X
admet-1570	479	4	h.s	h.s	PROPN
admet-1570	479	5	.	.	PROPN
admet-1570	479	6	mayerson	mayerson	PROPN
admet-1570	479	7	.	.	PUNCT
admet-1570	480	1	on	on	ADP
admet-1570	480	2	lymph	lymph	NOUN
admet-1570	480	3	and	and	CCONJ
admet-1570	480	4	lymphatics	lymphatic	NOUN
admet-1570	480	5	.	.	PUNCT
admet-1570	481	1	circulation	circulation	NOUN
admet-1570	481	2	28	28	NUM
admet-1570	481	3	(	(	PUNCT
admet-1570	481	4	1963	1963	NUM
admet-1570	481	5	)	)	PUNCT
admet-1570	481	6	839	839	NUM
admet-1570	481	7	-	-	SYM
admet-1570	481	8	842	842	NUM
admet-1570	481	9	.	.	PUNCT
admet-1570	482	1	https://doi.org/10.1161/01.cir.28.5.839	https://doi.org/10.1161/01.cir.28.5.839	NOUN
admet-1570	482	2	.	.	PUNCT
admet-1570	483	1	[	[	X
admet-1570	483	2	24	24	NUM
admet-1570	483	3	]	]	X
admet-1570	483	4	c.l	c.l	PROPN
admet-1570	483	5	.	.	PROPN
admet-1570	483	6	witte	witte	PROPN
admet-1570	483	7	,	,	PUNCT
admet-1570	483	8	m.h	m.h	PROPN
admet-1570	483	9	.	.	PROPN
admet-1570	483	10	witte	witte	PROPN
admet-1570	483	11	,	,	PUNCT
admet-1570	483	12	a.e	a.e	PROPN
admet-1570	483	13	.	.	PROPN
admet-1570	483	14	dumont	dumont	PROPN
admet-1570	483	15	,	,	PUNCT
admet-1570	483	16	w.r	w.r	PROPN
admet-1570	483	17	.	.	PROPN
admet-1570	483	18	cole	cole	PROPN
admet-1570	483	19	,	,	PUNCT
admet-1570	483	20	j.r	j.r	PROPN
admet-1570	483	21	.	.	PROPN
admet-1570	483	22	smith	smith	PROPN
admet-1570	483	23	.	.	PUNCT
admet-1570	484	1	protein	protein	NOUN
admet-1570	484	2	content	content	NOUN
admet-1570	484	3	in	in	ADP
admet-1570	484	4	lymph	lymph	NOUN
admet-1570	484	5	and	and	CCONJ
admet-1570	484	6	edema	edema	NOUN
admet-1570	484	7	fluid	fluid	NOUN
admet-1570	484	8	in	in	ADP
admet-1570	484	9	congestive	congestive	ADJ
admet-1570	484	10	heart	heart	NOUN
admet-1570	484	11	failure	failure	NOUN
admet-1570	484	12	.	.	PUNCT
admet-1570	485	1	circulation	circulation	NOUN
admet-1570	485	2	40	40	NUM
admet-1570	485	3	(	(	PUNCT
admet-1570	485	4	1969	1969	NUM
admet-1570	485	5	)	)	PUNCT
admet-1570	485	6	623	623	NUM
admet-1570	485	7	-	-	SYM
admet-1570	485	8	630	630	NUM
admet-1570	485	9	.	.	PUNCT
admet-1570	486	1	https://doi.org/10.1161/01.cir.40.5.623	https://doi.org/10.1161/01.cir.40.5.623	INTJ
admet-1570	486	2	.	.	PUNCT
admet-1570	487	1	[	[	X
admet-1570	487	2	25	25	NUM
admet-1570	487	3	]	]	X
admet-1570	487	4	d.g	d.g	PROPN
admet-1570	487	5	.	.	PROPN
admet-1570	487	6	levitt	levitt	PROPN
admet-1570	487	7	,	,	PUNCT
admet-1570	487	8	m.d	m.d	PROPN
admet-1570	487	9	.	.	PROPN
admet-1570	487	10	levitt	levitt	PROPN
admet-1570	487	11	.	.	PUNCT
admet-1570	488	1	human	human	ADJ
admet-1570	488	2	serum	serum	NOUN
admet-1570	488	3	albumin	albumin	NOUN
admet-1570	488	4	homeostasis	homeostasis	NOUN
admet-1570	488	5	:	:	PUNCT
admet-1570	488	6	a	a	DET
admet-1570	488	7	new	new	ADJ
admet-1570	488	8	look	look	NOUN
admet-1570	488	9	at	at	ADP
admet-1570	488	10	the	the	DET
admet-1570	488	11	roles	role	NOUN
admet-1570	488	12	of	of	ADP
admet-1570	488	13	synthesis	synthesis	NOUN
admet-1570	488	14	,	,	PUNCT
admet-1570	488	15	catabolism	catabolism	NOUN
admet-1570	488	16	,	,	PUNCT
admet-1570	488	17	renal	renal	ADJ
admet-1570	488	18	and	and	CCONJ
admet-1570	488	19	gastrointestinal	gastrointestinal	ADJ
admet-1570	488	20	excretion	excretion	NOUN
admet-1570	488	21	,	,	PUNCT
admet-1570	488	22	and	and	CCONJ
admet-1570	488	23	the	the	DET
admet-1570	488	24	clinical	clinical	ADJ
admet-1570	488	25	value	value	NOUN
admet-1570	488	26	of	of	ADP
admet-1570	488	27	serum	serum	NOUN
admet-1570	488	28	albumin	albumin	ADJ
admet-1570	488	29	measurements	measurement	NOUN
admet-1570	488	30	.	.	PUNCT
admet-1570	489	1	int	int	NOUN
admet-1570	490	1	j	j	PROPN
admet-1570	490	2	gen	gen	PROPN
admet-1570	490	3	med	med	ADJ
admet-1570	490	4	9	9	NUM
admet-1570	490	5	(	(	PUNCT
admet-1570	490	6	2016	2016	NUM
admet-1570	490	7	)	)	PUNCT
admet-1570	490	8	229	229	NUM
admet-1570	490	9	-	-	SYM
admet-1570	490	10	255	255	NUM
admet-1570	490	11	.	.	PUNCT
admet-1570	491	1	https://doi.org/10.2147/ijgm.s102819	https://doi.org/10.2147/ijgm.s102819	NOUN
admet-1570	491	2	.	.	PUNCT
admet-1570	492	1	[	[	X
admet-1570	492	2	26	26	NUM
admet-1570	492	3	]	]	X
admet-1570	492	4	m.d	m.d	PROPN
admet-1570	492	5	.	.	PROPN
admet-1570	492	6	el	el	PROPN
admet-1570	492	7	-	-	PROPN
admet-1570	492	8	zawahry	zawahry	PROPN
admet-1570	492	9	,	,	PUNCT
admet-1570	492	10	o.a	o.a	PROPN
admet-1570	492	11	.	.	PROPN
admet-1570	492	12	el	el	PROPN
admet-1570	492	13	-	-	PUNCT
admet-1570	492	14	roubi	roubi	ADJ
admet-1570	492	15	,	,	PUNCT
admet-1570	492	16	a.s	a.s	PROPN
admet-1570	492	17	.	.	PROPN
admet-1570	492	18	ibrahim	ibrahim	PROPN
admet-1570	492	19	.	.	PUNCT
admet-1570	493	1	protein	protein	NOUN
admet-1570	493	2	content	content	NOUN
admet-1570	493	3	of	of	ADP
admet-1570	493	4	thoracic	thoracic	NOUN
admet-1570	493	5	duct	duct	NOUN
admet-1570	493	6	lymph	lymph	NOUN
admet-1570	493	7	in	in	ADP
admet-1570	493	8	patients	patient	NOUN
admet-1570	493	9	with	with	ADP
admet-1570	493	10	bilharzial	bilharzial	ADJ
admet-1570	493	11	hepatic	hepatic	ADJ
admet-1570	493	12	fibrosis	fibrosis	NOUN
admet-1570	493	13	.	.	PUNCT
admet-1570	494	1	gastroenterology	gastroenterology	NOUN
admet-1570	494	2	72	72	NUM
admet-1570	494	3	(	(	PUNCT
admet-1570	494	4	1977	1977	NUM
admet-1570	494	5	)	)	PUNCT
admet-1570	494	6	617	617	NUM
admet-1570	494	7	-	-	SYM
admet-1570	494	8	620	620	NUM
admet-1570	494	9	.	.	PUNCT
admet-1570	495	1	https://www.ncbi.nlm.nih.gov/pubmed/838214	https://www.ncbi.nlm.nih.gov/pubmed/838214	NUM
admet-1570	495	2	.	.	PUNCT
admet-1570	496	1	[	[	X
admet-1570	496	2	27	27	NUM
admet-1570	496	3	]	]	X
admet-1570	496	4	b.g	b.g	PROPN
admet-1570	496	5	.	.	PROPN
admet-1570	496	6	shafiroff	shafiroff	PROPN
admet-1570	496	7	,	,	PUNCT
admet-1570	496	8	q.y	q.y	PROPN
admet-1570	496	9	.	.	PUNCT
admet-1570	496	10	kau	kau	PROPN
admet-1570	496	11	.	.	PUNCT
admet-1570	497	1	cannulation	cannulation	NOUN
admet-1570	497	2	of	of	ADP
admet-1570	497	3	the	the	DET
admet-1570	497	4	human	human	ADJ
admet-1570	497	5	thoracic	thoracic	NOUN
admet-1570	497	6	lymph	lymph	NOUN
admet-1570	497	7	duct	duct	NOUN
admet-1570	497	8	.	.	PUNCT
admet-1570	498	1	surgery	surgery	NOUN
admet-1570	498	2	45	45	NUM
admet-1570	498	3	(	(	PUNCT
admet-1570	498	4	1959	1959	NUM
admet-1570	498	5	)	)	PUNCT
admet-1570	498	6	814	814	NUM
admet-1570	498	7	-	-	SYM
admet-1570	498	8	819	819	NUM
admet-1570	498	9	.	.	PUNCT
admet-1570	498	10	https://www.ncbi.nlm.nih.gov/pubmed/13659321	https://www.ncbi.nlm.nih.gov/pubmed/13659321	NUM
admet-1570	498	11	.	.	PUNCT
admet-1570	499	1	[	[	X
admet-1570	499	2	28	28	NUM
admet-1570	499	3	]	]	X
admet-1570	499	4	r.j	r.j	PROPN
admet-1570	499	5	.	.	PROPN
admet-1570	499	6	keizer	keizer	PROPN
admet-1570	499	7	,	,	PUNCT
admet-1570	499	8	a.d	a.d	PROPN
admet-1570	499	9	.	.	PROPN
admet-1570	499	10	huitema	huitema	PROPN
admet-1570	499	11	,	,	PUNCT
admet-1570	499	12	j.h	j.h	PROPN
admet-1570	499	13	.	.	PROPN
admet-1570	499	14	schellens	schellens	PROPN
admet-1570	499	15	,	,	PUNCT
admet-1570	499	16	j.h	j.h	PROPN
admet-1570	499	17	.	.	PROPN
admet-1570	499	18	beijnen	beijnen	NOUN
admet-1570	499	19	.	.	PUNCT
admet-1570	500	1	clinical	clinical	ADJ
admet-1570	500	2	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	500	3	of	of	ADP
admet-1570	500	4	therapeutic	therapeutic	ADJ
admet-1570	500	5	monoclonal	monoclonal	NOUN
admet-1570	500	6	antibodies	antibodie	VERB
admet-1570	500	7	.	.	PUNCT
admet-1570	501	1	clin	clin	PROPN
admet-1570	501	2	pharmacokinet	pharmacokinet	PROPN
admet-1570	501	3	49	49	NUM
admet-1570	501	4	(	(	PUNCT
admet-1570	501	5	2010	2010	NUM
admet-1570	501	6	)	)	PUNCT
admet-1570	501	7	493	493	NUM
admet-1570	501	8	-	-	SYM
admet-1570	501	9	507	507	NUM
admet-1570	501	10	.	.	PUNCT
admet-1570	502	1	https://doi.org/10.2165/11531280000000000-00000	https://doi.org/10.2165/11531280000000000-00000	NOUN
admet-1570	502	2	.	.	PUNCT
admet-1570	503	1	[	[	X
admet-1570	503	2	29	29	NUM
admet-1570	503	3	]	]	X
admet-1570	503	4	j.h	j.h	PROPN
admet-1570	503	5	.	.	PROPN
admet-1570	503	6	lin	lin	PROPN
admet-1570	503	7	.	.	PUNCT
admet-1570	504	1	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	504	2	of	of	ADP
admet-1570	504	3	biotech	biotech	ADJ
admet-1570	504	4	drugs	drug	NOUN
admet-1570	504	5	:	:	PUNCT
admet-1570	504	6	peptides	peptide	NOUN
admet-1570	504	7	,	,	PUNCT
admet-1570	504	8	proteins	protein	NOUN
admet-1570	504	9	and	and	CCONJ
admet-1570	504	10	monoclonal	monoclonal	NOUN
admet-1570	504	11	antibodies	antibodie	VERB
admet-1570	504	12	.	.	PUNCT
admet-1570	505	1	curr	curr	PROPN
admet-1570	505	2	drug	drug	PROPN
admet-1570	505	3	metab	metab	PROPN
admet-1570	505	4	10	10	NUM
admet-1570	505	5	(	(	PUNCT
admet-1570	505	6	2009	2009	NUM
admet-1570	505	7	)	)	PUNCT
admet-1570	505	8	661	661	NUM
admet-1570	505	9	-	-	SYM
admet-1570	505	10	691	691	NUM
admet-1570	505	11	.	.	PUNCT
admet-1570	506	1	https://doi.org/10.2174/138920009789895499	https://doi.org/10.2174/138920009789895499	NOUN
admet-1570	506	2	.	.	PUNCT
admet-1570	507	1	[	[	X
admet-1570	507	2	30	30	NUM
admet-1570	507	3	]	]	X
admet-1570	507	4	e.d	e.d	PROPN
admet-1570	507	5	.	.	PROPN
admet-1570	507	6	lobo	lobo	PROPN
admet-1570	507	7	,	,	PUNCT
admet-1570	507	8	r.j	r.j	PROPN
admet-1570	507	9	.	.	PROPN
admet-1570	507	10	hansen	hansen	PROPN
admet-1570	507	11	,	,	PUNCT
admet-1570	507	12	j.p	j.p	PROPN
admet-1570	507	13	.	.	PROPN
admet-1570	507	14	balthasar	balthasar	PROPN
admet-1570	507	15	.	.	PUNCT
admet-1570	508	1	antibody	antibody	NOUN
admet-1570	508	2	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	508	3	and	and	CCONJ
admet-1570	508	4	pharmacodynamics	pharmacodynamic	NOUN
admet-1570	508	5	.	.	PUNCT
admet-1570	509	1	journal	journal	PROPN
admet-1570	509	2	of	of	ADP
admet-1570	509	3	pharmaceutical	pharmaceutical	NOUN
admet-1570	509	4	sciences	science	NOUN
admet-1570	509	5	93	93	NUM
admet-1570	509	6	(	(	PUNCT
admet-1570	509	7	2004	2004	NUM
admet-1570	509	8	)	)	PUNCT
admet-1570	509	9	2645	2645	NUM
admet-1570	509	10	-	-	SYM
admet-1570	509	11	2668	2668	NUM
admet-1570	509	12	.	.	PUNCT
admet-1570	510	1	https://doi.org/10.1002/jps.20178	https://doi.org/10.1002/jps.20178	ADV
admet-1570	510	2	[	[	X
admet-1570	510	3	31	31	NUM
admet-1570	510	4	]	]	X
admet-1570	510	5	d.a	d.a	PROPN
admet-1570	510	6	.	.	PROPN
admet-1570	510	7	smith	smith	PROPN
admet-1570	510	8	,	,	PUNCT
admet-1570	510	9	e.a	e.a	PROPN
admet-1570	510	10	.	.	PROPN
admet-1570	510	11	minthorn	minthorn	PROPN
admet-1570	510	12	,	,	PUNCT
admet-1570	510	13	m.	m.	NOUN
admet-1570	510	14	beerahee	beerahee	PROPN
admet-1570	510	15	.	.	PUNCT
admet-1570	511	1	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	511	2	and	and	CCONJ
admet-1570	511	3	pharmacodynamics	pharmacodynamic	NOUN
admet-1570	511	4	of	of	ADP
admet-1570	511	5	mepolizumab	mepolizumab	NOUN
admet-1570	511	6	,	,	PUNCT
admet-1570	511	7	an	an	DET
admet-1570	511	8	anti	anti	ADJ
admet-1570	511	9	-	-	ADJ
admet-1570	511	10	interleukin-5	interleukin-5	ADJ
admet-1570	511	11	monoclonal	monoclonal	NOUN
admet-1570	511	12	antibody	antibody	NOUN
admet-1570	511	13	.	.	PUNCT
admet-1570	512	1	clin	clin	PROPN
admet-1570	512	2	pharmacokinet	pharmacokinet	PROPN
admet-1570	512	3	50	50	NUM
admet-1570	512	4	(	(	PUNCT
admet-1570	512	5	2011	2011	NUM
admet-1570	512	6	)	)	PUNCT
admet-1570	512	7	215	215	NUM
admet-1570	512	8	-	-	SYM
admet-1570	512	9	227	227	NUM
admet-1570	512	10	.	.	PUNCT
admet-1570	512	11	https://doi.org/10.2165/11584340-000000000-00000	https://doi.org/10.2165/11584340-000000000-00000	NOUN
admet-1570	512	12	.	.	PUNCT
admet-1570	513	1	[	[	X
admet-1570	513	2	32	32	NUM
admet-1570	513	3	]	]	X
admet-1570	513	4	u.	u.	PROPN
admet-1570	513	5	klotz	klotz	PROPN
admet-1570	513	6	,	,	PUNCT
admet-1570	513	7	a.	a.	NOUN
admet-1570	513	8	teml	teml	PROPN
admet-1570	513	9	,	,	PUNCT
admet-1570	513	10	m.	m.	NOUN
admet-1570	513	11	schwab	schwab	PROPN
admet-1570	513	12	.	.	PUNCT
admet-1570	514	1	clinical	clinical	ADJ
admet-1570	514	2	pharmacokinetics	pharmacokinetic	NOUN
admet-1570	514	3	and	and	CCONJ
admet-1570	514	4	use	use	NOUN
admet-1570	514	5	of	of	ADP
admet-1570	514	6	infliximab	infliximab	NOUN
admet-1570	514	7	.	.	PUNCT
admet-1570	515	1	clin	clin	PROPN
admet-1570	515	2	pharmacokinet	pharmacokinet	PROPN
admet-1570	515	3	46	46	NUM
admet-1570	515	4	(	(	PUNCT
admet-1570	515	5	2007	2007	NUM
admet-1570	515	6	)	)	PUNCT
admet-1570	515	7	645	645	NUM
admet-1570	515	8	-	-	SYM
admet-1570	515	9	660	660	NUM
admet-1570	515	10	.	.	PUNCT
admet-1570	516	1	https://doi.org/10.2165/00003088-200746080-00002	https://doi.org/10.2165/00003088-200746080-00002	NOUN
admet-1570	516	2	.	.	PUNCT
admet-1570	517	1	[	[	X
admet-1570	517	2	33	33	NUM
admet-1570	517	3	]	]	PUNCT
admet-1570	517	4	w.	w.	PROPN
admet-1570	517	5	junge	junge	PROPN
admet-1570	517	6	,	,	PUNCT
admet-1570	517	7	m.	m.	NOUN
admet-1570	517	8	malyusz	malyusz	PROPN
admet-1570	517	9	,	,	PUNCT
admet-1570	517	10	h.j	h.j	PROPN
admet-1570	517	11	.	.	PROPN
admet-1570	517	12	ehrens	ehren	NOUN
admet-1570	517	13	.	.	PUNCT
admet-1570	518	1	the	the	DET
admet-1570	518	2	role	role	NOUN
admet-1570	518	3	of	of	ADP
admet-1570	518	4	the	the	DET
admet-1570	518	5	kidney	kidney	NOUN
admet-1570	518	6	in	in	ADP
admet-1570	518	7	the	the	DET
admet-1570	518	8	elimination	elimination	NOUN
admet-1570	518	9	of	of	ADP
admet-1570	518	10	pancreatic	pancreatic	ADJ
admet-1570	518	11	lipase	lipase	NOUN
admet-1570	518	12	and	and	CCONJ
admet-1570	518	13	amylase	amylase	NOUN
admet-1570	518	14	from	from	ADP
admet-1570	518	15	blood	blood	NOUN
admet-1570	518	16	.	.	PUNCT
admet-1570	519	1	j	j	PROPN
admet-1570	519	2	clin	clin	PROPN
admet-1570	519	3	chem	chem	PROPN
admet-1570	519	4	clin	clin	PROPN
admet-1570	519	5	biochem	biochem	PROPN
admet-1570	519	6	23	23	NUM
admet-1570	519	7	(	(	PUNCT
admet-1570	519	8	1985	1985	NUM
admet-1570	519	9	)	)	PUNCT
admet-1570	519	10	387	387	NUM
admet-1570	519	11	-	-	SYM
admet-1570	519	12	392	392	NUM
admet-1570	519	13	.	.	PUNCT
admet-1570	519	14	https://doi.org/10.1515/cclm.1985.23.7.387	https://doi.org/10.1515/cclm.1985.23.7.387	PROPN
admet-1570	519	15	.	.	PUNCT
admet-1570	520	1	[	[	X
admet-1570	520	2	34	34	NUM
admet-1570	520	3	]	]	PUNCT
admet-1570	520	4	m.	m.	NOUN
admet-1570	520	5	malyusz	malyusz	PROPN
admet-1570	520	6	,	,	PUNCT
admet-1570	520	7	p.	p.	NOUN
admet-1570	520	8	wrigge	wrigge	PROPN
admet-1570	520	9	,	,	PUNCT
admet-1570	520	10	d.	d.	PROPN
admet-1570	520	11	caliebe	caliebe	PROPN
admet-1570	520	12	,	,	PUNCT
admet-1570	520	13	w.	w.	PROPN
admet-1570	520	14	junge	junge	PROPN
admet-1570	520	15	.	.	PUNCT
admet-1570	521	1	renal	renal	ADJ
admet-1570	521	2	handling	handling	NOUN
admet-1570	521	3	of	of	ADP
admet-1570	521	4	125i	125i	NOUN
admet-1570	521	5	-	-	PUNCT
admet-1570	521	6	labelled	label	VERB
admet-1570	521	7	homologous	homologous	ADJ
admet-1570	521	8	pancreatic	pancreatic	ADJ
admet-1570	521	9	lipase	lipase	NOUN
admet-1570	521	10	and	and	CCONJ
admet-1570	521	11	amylase	amylase	NOUN
admet-1570	521	12	in	in	ADP
admet-1570	521	13	the	the	DET
admet-1570	521	14	rat	rat	NOUN
admet-1570	521	15	.	.	PROPN
admet-1570	522	1	j	j	PROPN
admet-1570	522	2	clin	clin	PROPN
admet-1570	522	3	chem	chem	PROPN
admet-1570	522	4	clin	clin	PROPN
admet-1570	522	5	biochem	biochem	PROPN
admet-1570	522	6	26	26	NUM
admet-1570	522	7	(	(	PUNCT
admet-1570	522	8	1988	1988	NUM
admet-1570	522	9	)	)	PUNCT
admet-1570	522	10	611	611	NUM
admet-1570	522	11	-	-	SYM
admet-1570	522	12	615	615	NUM
admet-1570	522	13	.	.	PUNCT
admet-1570	523	1	https://doi.org/10.1515/cclm.1988.26.10.611	https://doi.org/10.1515/cclm.1988.26.10.611	NOUN
admet-1570	523	2	.	.	PUNCT
admet-1570	524	1	[	[	X
admet-1570	524	2	35	35	NUM
admet-1570	524	3	]	]	SYM
admet-1570	524	4	w.c	w.c	PROPN
admet-1570	524	5	.	.	PROPN
admet-1570	524	6	duane	duane	PROPN
admet-1570	524	7	,	,	PUNCT
admet-1570	524	8	r.	r.	PROPN
admet-1570	524	9	frerichs	frerichs	PROPN
admet-1570	524	10	,	,	PUNCT
admet-1570	524	11	m.d	m.d	PROPN
admet-1570	524	12	.	.	PROPN
admet-1570	524	13	levitt	levitt	PROPN
admet-1570	524	14	.	.	PUNCT
admet-1570	525	1	distribution	distribution	NOUN
admet-1570	525	2	,	,	PUNCT
admet-1570	525	3	turnover	turnover	NOUN
admet-1570	525	4	,	,	PUNCT
admet-1570	525	5	and	and	CCONJ
admet-1570	525	6	mechanism	mechanism	NOUN
admet-1570	525	7	of	of	ADP
admet-1570	525	8	renal	renal	ADJ
admet-1570	525	9	excretion	excretion	NOUN
admet-1570	525	10	of	of	ADP
admet-1570	525	11	amylase	amylase	NOUN
admet-1570	525	12	in	in	ADP
admet-1570	525	13	the	the	DET
admet-1570	525	14	baboon	baboon	NOUN
admet-1570	525	15	.	.	PUNCT
admet-1570	526	1	j	j	PROPN
admet-1570	526	2	clin	clin	PROPN
admet-1570	526	3	invest	invest	VERB
admet-1570	526	4	50	50	NUM
admet-1570	526	5	(	(	PUNCT
admet-1570	526	6	1971	1971	NUM
admet-1570	526	7	)	)	PUNCT
admet-1570	526	8	156	156	NUM
admet-1570	526	9	-	-	SYM
admet-1570	526	10	165	165	NUM
admet-1570	526	11	.	.	PUNCT
admet-1570	526	12	https://doi.org/10.1172/jci106469	https://doi.org/10.1172/jci106469	NOUN
admet-1570	526	13	.	.	PUNCT
admet-1570	527	1	[	[	X
admet-1570	527	2	36	36	NUM
admet-1570	527	3	]	]	X
admet-1570	527	4	w.c	w.c	PROPN
admet-1570	527	5	.	.	PROPN
admet-1570	527	6	duane	duane	PROPN
admet-1570	527	7	,	,	PUNCT
admet-1570	527	8	r.	r.	PROPN
admet-1570	527	9	frerichs	frerichs	PROPN
admet-1570	527	10	,	,	PUNCT
admet-1570	527	11	m.d	m.d	PROPN
admet-1570	527	12	.	.	PROPN
admet-1570	527	13	levitt	levitt	PROPN
admet-1570	527	14	.	.	PUNCT
admet-1570	528	1	simultaneous	simultaneous	ADJ
admet-1570	528	2	study	study	NOUN
admet-1570	528	3	of	of	ADP
admet-1570	528	4	the	the	DET
admet-1570	528	5	metabolic	metabolic	NOUN
admet-1570	528	6	turnover	turnover	NOUN
admet-1570	528	7	and	and	CCONJ
admet-1570	528	8	renal	renal	ADJ
admet-1570	528	9	excretion	excretion	NOUN
admet-1570	528	10	of	of	ADP
admet-1570	528	11	salivary	salivary	NOUN
admet-1570	528	12	amylase125	amylase125	PUNCT
admet-1570	529	1	i	i	PRON
admet-1570	529	2	and	and	CCONJ
admet-1570	529	3	pancreatic	pancreatic	ADJ
admet-1570	529	4	amylase131	amylase131	PROPN
admet-1570	529	5	i	i	PRON
admet-1570	529	6	in	in	ADP
admet-1570	529	7	the	the	DET
admet-1570	529	8	baboon	baboon	NOUN
admet-1570	529	9	.	.	PUNCT
admet-1570	530	1	j	j	PROPN
admet-1570	530	2	clin	clin	PROPN
admet-1570	530	3	invest	invest	VERB
admet-1570	530	4	51	51	NUM
admet-1570	530	5	(	(	PUNCT
admet-1570	530	6	1972	1972	NUM
admet-1570	530	7	)	)	PUNCT
admet-1570	530	8	15041513	15041513	NUM
admet-1570	530	9	.	.	PUNCT
admet-1570	531	1	https://doi.org/10.1172/jci106947	https://doi.org/10.1172/jci106947	X
admet-1570	531	2	.	.	PUNCT
admet-1570	532	1	[	[	X
admet-1570	532	2	37	37	NUM
admet-1570	532	3	]	]	X
admet-1570	532	4	l.j	l.j	PROPN
admet-1570	532	5	.	.	PROPN
admet-1570	532	6	dixon	dixon	PROPN
admet-1570	532	7	,	,	PUNCT
admet-1570	532	8	m.	m.	NOUN
admet-1570	532	9	barnes	barnes	PROPN
admet-1570	532	10	,	,	PUNCT
admet-1570	532	11	h.	h.	PROPN
admet-1570	532	12	tang	tang	PROPN
admet-1570	532	13	,	,	PUNCT
admet-1570	532	14	m.t	m.t	PROPN
admet-1570	532	15	.	.	PROPN
admet-1570	532	16	pritchard	pritchard	PROPN
admet-1570	532	17	,	,	PUNCT
admet-1570	532	18	l.e	l.e	PROPN
admet-1570	532	19	.	.	PROPN
admet-1570	532	20	nagy	nagy	PROPN
admet-1570	532	21	.	.	PUNCT
admet-1570	533	1	kupffer	kupffer	NOUN
admet-1570	533	2	cells	cell	NOUN
admet-1570	533	3	in	in	ADP
admet-1570	533	4	the	the	DET
admet-1570	533	5	liver	liver	NOUN
admet-1570	533	6	.	.	PUNCT
admet-1570	534	1	compr	compr	PROPN
admet-1570	534	2	physiol	physiol	PROPN
admet-1570	534	3	3	3	NUM
admet-1570	534	4	(	(	PUNCT
admet-1570	534	5	2013	2013	NUM
admet-1570	534	6	)	)	PUNCT
admet-1570	534	7	785	785	NUM
admet-1570	534	8	-	-	SYM
admet-1570	534	9	797	797	NUM
admet-1570	534	10	.	.	PUNCT
admet-1570	535	1	https://doi.org/10.1002/cphy.c120026	https://doi.org/10.1002/cphy.c120026	PROPN
admet-1570	535	2	.	.	PUNCT
admet-1570	536	1	https://doi.org/10.1186/1472-6904-3-3	https://doi.org/10.1186/1472-6904-3-3	PROPN
admet-1570	537	1	file:///d:/zoranm	file:///d:/zoranm	PROPN
admet-1570	537	2	/	/	SYM
admet-1570	537	3	downloads	downloads	PROPN
admet-1570	537	4	/	/	SYM
admet-1570	537	5	www.pkquest.com	www.pkquest.com	NOUN
admet-1570	537	6	https://doi.org/10.5599/admet.579	https://doi.org/10.5599/admet.579	NOUN
admet-1570	537	7	https://www.ncbi.nlm.nih.gov/pubmed/6754456	https://www.ncbi.nlm.nih.gov/pubmed/6754456	NOUN
admet-1570	537	8	https://www.ncbi.nlm.nih.gov/pubmed/20266768	https://www.ncbi.nlm.nih.gov/pubmed/20266768	NUM
admet-1570	537	9	https://doi.org/10.1002/1097-0142(197203)29:3	https://doi.org/10.1002/1097-0142(197203)29:3	VERB
admet-1570	537	10	https://doi.org/10.1161/01.cir.28.5.839	https://doi.org/10.1161/01.cir.28.5.839	PROPN
admet-1570	537	11	https://doi.org/10.1161/01.cir.28.5.839	https://doi.org/10.1161/01.cir.28.5.839	PROPN
admet-1570	538	1	https://doi.org/10.1161/01.cir.40.5.623	https://doi.org/10.1161/01.cir.40.5.623	PROPN
admet-1570	538	2	https://doi.org/10.2147/ijgm.s102819	https://doi.org/10.2147/ijgm.s102819	VERB
admet-1570	538	3	https://www.ncbi.nlm.nih.gov/pubmed/838214	https://www.ncbi.nlm.nih.gov/pubmed/838214	NUM
admet-1570	538	4	https://www.ncbi.nlm.nih.gov/pubmed/838214	https://www.ncbi.nlm.nih.gov/pubmed/838214	NUM
admet-1570	538	5	https://www.ncbi.nlm.nih.gov/pubmed/13659321	https://www.ncbi.nlm.nih.gov/pubmed/13659321	NUM
admet-1570	538	6	https://doi.org/10.2165/11531280-000000000-00000	https://doi.org/10.2165/11531280-000000000-00000	ADJ
admet-1570	538	7	https://doi.org/10.2165/11531280-000000000-00000	https://doi.org/10.2165/11531280-000000000-00000	PROPN
admet-1570	539	1	https://doi.org/10.2174/138920009789895499	https://doi.org/10.2174/138920009789895499	X
admet-1570	539	2	https://doi.org/10.1002/jps.20178	https://doi.org/10.1002/jps.20178	ADV
admet-1570	539	3	https://doi.org/10.2165/11584340-000000000-00000	https://doi.org/10.2165/11584340-000000000-00000	INTJ
admet-1570	540	1	https://doi.org/10.2165/11584340-000000000-00000	https://doi.org/10.2165/11584340-000000000-00000	INTJ
admet-1570	541	1	https://doi.org/10.2165/00003088-200746080-00002	https://doi.org/10.2165/00003088-200746080-00002	NOUN
admet-1570	541	2	https://doi.org/10.1515/cclm.1985.23.7.387	https://doi.org/10.1515/cclm.1985.23.7.387	PROPN
admet-1570	541	3	https://doi.org/10.1515/cclm.1985.23.7.387	https://doi.org/10.1515/cclm.1985.23.7.387	PROPN
admet-1570	541	4	https://doi.org/10.1515/cclm.1988.26.10.611	https://doi.org/10.1515/cclm.1988.26.10.611	NOUN
admet-1570	541	5	https://doi.org/10.1515/cclm.1988.26.10.611	https://doi.org/10.1515/cclm.1988.26.10.611	NOUN
admet-1570	541	6	https://doi.org/10.1172/jci106469	https://doi.org/10.1172/jci106469	PROPN
admet-1570	541	7	https://doi.org/10.1172/jci106947	https://doi.org/10.1172/jci106947	VERB
admet-1570	541	8	https://doi.org/10.1002/cphy.c120026	https://doi.org/10.1002/cphy.c120026	PROPN
admet-1570	541	9	admet	admet	PROPN
admet-1570	541	10	&	&	CCONJ
admet-1570	541	11	dmpk	dmpk	PROPN
admet-1570	541	12	11(1	11(1	NUM
admet-1570	541	13	)	)	PUNCT
admet-1570	541	14	(	(	PUNCT
admet-1570	541	15	2023	2023	NUM
admet-1570	541	16	)	)	PUNCT
admet-1570	541	17	57	57	NUM
admet-1570	541	18	-	-	SYM
admet-1570	541	19	80	80	NUM
admet-1570	541	20	protein	protein	NOUN
admet-1570	541	21	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	541	22	model	model	NOUN
admet-1570	541	23	doi	doi	PROPN
admet-1570	541	24	:	:	PUNCT
admet-1570	541	25	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	NOUN
admet-1570	541	26	79	79	NUM
admet-1570	542	1	[	[	X
admet-1570	542	2	38	38	NUM
admet-1570	542	3	]	]	X
admet-1570	542	4	m.j	m.j	PROPN
admet-1570	542	5	.	.	PROPN
admet-1570	542	6	smit	smit	PROPN
admet-1570	542	7	,	,	PUNCT
admet-1570	542	8	a.m.	a.m.	PROPN
admet-1570	542	9	duursma	duursma	PROPN
admet-1570	542	10	,	,	PUNCT
admet-1570	542	11	j.m	j.m	PROPN
admet-1570	542	12	.	.	PROPN
admet-1570	542	13	bouma	bouma	PROPN
admet-1570	542	14	,	,	PUNCT
admet-1570	542	15	m.	m.	PROPN
admet-1570	542	16	gruber	gruber	PROPN
admet-1570	542	17	.	.	PUNCT
admet-1570	543	1	receptor	receptor	NOUN
admet-1570	543	2	-	-	PUNCT
admet-1570	543	3	mediated	mediate	VERB
admet-1570	543	4	endocytosis	endocytosis	NOUN
admet-1570	543	5	of	of	ADP
admet-1570	543	6	lactate	lactate	NOUN
admet-1570	543	7	dehydrogenase	dehydrogenase	NOUN
admet-1570	543	8	m4	m4	PROPN
admet-1570	543	9	by	by	ADP
admet-1570	543	10	liver	liver	NOUN
admet-1570	543	11	macrophages	macrophage	NOUN
admet-1570	543	12	:	:	PUNCT
admet-1570	543	13	a	a	DET
admet-1570	543	14	mechanism	mechanism	NOUN
admet-1570	543	15	for	for	ADP
admet-1570	543	16	elimination	elimination	NOUN
admet-1570	543	17	of	of	ADP
admet-1570	543	18	enzymes	enzyme	NOUN
admet-1570	543	19	from	from	ADP
admet-1570	543	20	plasma	plasma	NOUN
admet-1570	543	21	.	.	PUNCT
admet-1570	544	1	evidence	evidence	NOUN
admet-1570	544	2	for	for	ADP
admet-1570	544	3	competition	competition	NOUN
admet-1570	544	4	by	by	ADP
admet-1570	544	5	creatine	creatine	PROPN
admet-1570	544	6	kinase	kinase	PROPN
admet-1570	544	7	mm	mm	PROPN
admet-1570	544	8	,	,	PUNCT
admet-1570	544	9	adenylate	adenylate	ADJ
admet-1570	544	10	kinase	kinase	NOUN
admet-1570	544	11	,	,	PUNCT
admet-1570	544	12	malate	malate	NOUN
admet-1570	544	13	,	,	PUNCT
admet-1570	544	14	and	and	CCONJ
admet-1570	544	15	alcohol	alcohol	NOUN
admet-1570	544	16	dehydrogenase	dehydrogenase	NOUN
admet-1570	544	17	.	.	PUNCT
admet-1570	545	1	j	j	PROPN
admet-1570	545	2	biol	biol	PROPN
admet-1570	545	3	chem	chem	NOUN
admet-1570	545	4	262	262	NUM
admet-1570	545	5	(	(	PUNCT
admet-1570	545	6	1987	1987	NUM
admet-1570	545	7	)	)	PUNCT
admet-1570	545	8	13020	13020	NUM
admet-1570	545	9	-	-	SYM
admet-1570	545	10	13026	13026	NUM
admet-1570	545	11	.	.	PUNCT
admet-1570	546	1	https://www.ncbi.nlm.nih.gov/pubmed/2820961	https://www.ncbi.nlm.nih.gov/pubmed/2820961	X
admet-1570	546	2	.	.	PUNCT
admet-1570	547	1	[	[	X
admet-1570	547	2	39	39	NUM
admet-1570	547	3	]	]	X
admet-1570	547	4	g.a	g.a	PROPN
admet-1570	547	5	.	.	PROPN
admet-1570	547	6	fleisher	fleisher	PROPN
admet-1570	547	7	,	,	PUNCT
admet-1570	547	8	k.g	k.g	PROPN
admet-1570	547	9	.	.	PROPN
admet-1570	547	10	wakim	wakim	PROPN
admet-1570	547	11	.	.	PUNCT
admet-1570	548	1	the	the	DET
admet-1570	548	2	fate	fate	NOUN
admet-1570	548	3	of	of	ADP
admet-1570	548	4	enzymes	enzyme	NOUN
admet-1570	548	5	in	in	ADP
admet-1570	548	6	body	body	NOUN
admet-1570	548	7	fluids	fluid	NOUN
admet-1570	548	8	-	-	PUNCT
admet-1570	548	9	an	an	DET
admet-1570	548	10	experimental	experimental	ADJ
admet-1570	548	11	study	study	NOUN
admet-1570	548	12	.	.	PUNCT
admet-1570	549	1	i.	i.	NOUN
admet-1570	549	2	disappearance	disappearance	NOUN
admet-1570	549	3	rates	rate	NOUN
admet-1570	549	4	of	of	ADP
admet-1570	549	5	glutamic	glutamic	ADJ
admet-1570	549	6	-	-	PUNCT
admet-1570	549	7	pyruvic	pyruvic	ADJ
admet-1570	549	8	transaminase	transaminase	NOUN
admet-1570	549	9	under	under	ADP
admet-1570	549	10	various	various	ADJ
admet-1570	549	11	conditions	condition	NOUN
admet-1570	549	12	.	.	PUNCT
admet-1570	550	1	j	j	PROPN
admet-1570	550	2	lab	lab	PROPN
admet-1570	550	3	clin	clin	PROPN
admet-1570	550	4	med	me	VERB
admet-1570	550	5	61	61	NUM
admet-1570	550	6	(	(	PUNCT
admet-1570	550	7	1963	1963	NUM
admet-1570	550	8	)	)	PUNCT
admet-1570	550	9	76	76	NUM
admet-1570	550	10	-	-	SYM
admet-1570	550	11	85	85	NUM
admet-1570	550	12	.	.	PUNCT
admet-1570	550	13	https://www.ncbi.nlm.nih.gov/pubmed/13945478	https://www.ncbi.nlm.nih.gov/pubmed/13945478	X
admet-1570	550	14	.	.	PUNCT
admet-1570	551	1	[	[	X
admet-1570	551	2	40	40	NUM
admet-1570	551	3	]	]	PUNCT
admet-1570	551	4	h.	h.	PROPN
admet-1570	551	5	schad	schad	PROPN
admet-1570	551	6	,	,	PUNCT
admet-1570	551	7	h.	h.	PROPN
admet-1570	551	8	brechtelsbauer	brechtelsbauer	PROPN
admet-1570	551	9	.	.	PUNCT
admet-1570	552	1	thoracic	thoracic	NOUN
admet-1570	552	2	duct	duct	NOUN
admet-1570	552	3	lymph	lymph	NOUN
admet-1570	552	4	in	in	ADP
admet-1570	552	5	conscious	conscious	ADJ
admet-1570	552	6	dogs	dog	NOUN
admet-1570	552	7	at	at	ADP
admet-1570	552	8	rest	rest	NOUN
admet-1570	552	9	and	and	CCONJ
admet-1570	552	10	during	during	ADP
admet-1570	552	11	changes	change	NOUN
admet-1570	552	12	of	of	ADP
admet-1570	552	13	physical	physical	ADJ
admet-1570	552	14	activity	activity	NOUN
admet-1570	552	15	.	.	PUNCT
admet-1570	553	1	pflugers	pfluger	NOUN
admet-1570	553	2	arch	arch	VERB
admet-1570	553	3	367	367	NUM
admet-1570	553	4	(	(	PUNCT
admet-1570	553	5	1977	1977	NUM
admet-1570	553	6	)	)	PUNCT
admet-1570	553	7	235	235	NUM
admet-1570	553	8	-	-	SYM
admet-1570	553	9	240	240	NUM
admet-1570	553	10	.	.	PUNCT
admet-1570	554	1	https://doi.org/10.1007/bf00581360	https://doi.org/10.1007/bf00581360	X
admet-1570	554	2	.	.	PUNCT
admet-1570	555	1	[	[	X
admet-1570	555	2	41	41	NUM
admet-1570	555	3	]	]	X
admet-1570	555	4	g.a	g.a	PROPN
admet-1570	555	5	.	.	PROPN
admet-1570	555	6	fleisher	fleisher	PROPN
admet-1570	555	7	,	,	PUNCT
admet-1570	555	8	k.g	k.g	PROPN
admet-1570	555	9	.	.	PROPN
admet-1570	555	10	wakim	wakim	PROPN
admet-1570	555	11	.	.	PUNCT
admet-1570	556	1	presence	presence	NOUN
admet-1570	556	2	of	of	ADP
admet-1570	556	3	two	two	NUM
admet-1570	556	4	glutamic	glutamic	ADJ
admet-1570	556	5	-	-	PUNCT
admet-1570	556	6	oxalacetic	oxalacetic	ADJ
admet-1570	556	7	transaminases	transaminase	NOUN
admet-1570	556	8	in	in	ADP
admet-1570	556	9	serum	serum	NOUN
admet-1570	556	10	of	of	ADP
admet-1570	556	11	dogs	dog	NOUN
admet-1570	556	12	following	follow	VERB
admet-1570	556	13	acute	acute	ADJ
admet-1570	556	14	injury	injury	NOUN
admet-1570	556	15	of	of	ADP
admet-1570	556	16	the	the	DET
admet-1570	556	17	liver	liver	NOUN
admet-1570	556	18	.	.	PUNCT
admet-1570	557	1	proc	proc	NOUN
admet-1570	557	2	soc	soc	PROPN
admet-1570	557	3	exp	exp	PROPN
admet-1570	557	4	biol	biol	PROPN
admet-1570	557	5	med	me	VERB
admet-1570	557	6	106	106	NUM
admet-1570	557	7	(	(	PUNCT
admet-1570	557	8	1961	1961	NUM
admet-1570	557	9	)	)	PUNCT
admet-1570	557	10	283	283	NUM
admet-1570	557	11	-	-	SYM
admet-1570	557	12	286	286	NUM
admet-1570	557	13	.	.	PUNCT
admet-1570	558	1	https://doi.org/10.3181/00379727-106-26310	https://doi.org/10.3181/00379727-106-26310	PROPN
admet-1570	558	2	.	.	PUNCT
admet-1570	559	1	[	[	X
admet-1570	559	2	42	42	NUM
admet-1570	559	3	]	]	X
admet-1570	559	4	y.	y.	PROPN
admet-1570	559	5	kamimoto	kamimoto	PROPN
admet-1570	559	6	,	,	PUNCT
admet-1570	559	7	s.	s.	PROPN
admet-1570	559	8	horiuchi	horiuchi	PROPN
admet-1570	559	9	,	,	PUNCT
admet-1570	559	10	s.	s.	PROPN
admet-1570	559	11	tanase	tanase	PROPN
admet-1570	559	12	,	,	PUNCT
admet-1570	559	13	y.	y.	PROPN
admet-1570	559	14	morino	morino	PROPN
admet-1570	559	15	.	.	PUNCT
admet-1570	560	1	plasma	plasma	NOUN
admet-1570	560	2	clearance	clearance	NOUN
admet-1570	560	3	of	of	ADP
admet-1570	560	4	intravenously	intravenously	ADV
admet-1570	560	5	injected	inject	VERB
admet-1570	560	6	aspartate	aspartate	NOUN
admet-1570	560	7	aminotransferase	aminotransferase	NOUN
admet-1570	560	8	isozymes	isozyme	NOUN
admet-1570	560	9	:	:	PUNCT
admet-1570	560	10	evidence	evidence	NOUN
admet-1570	560	11	for	for	ADP
admet-1570	560	12	preferential	preferential	ADJ
admet-1570	560	13	uptake	uptake	NOUN
admet-1570	560	14	by	by	ADP
admet-1570	560	15	sinusoidal	sinusoidal	ADJ
admet-1570	560	16	liver	liver	NOUN
admet-1570	560	17	cells	cell	NOUN
admet-1570	560	18	.	.	PUNCT
admet-1570	561	1	hepatology	hepatology	NOUN
admet-1570	561	2	5	5	NUM
admet-1570	561	3	(	(	PUNCT
admet-1570	561	4	1985	1985	NUM
admet-1570	561	5	)	)	PUNCT
admet-1570	561	6	367	367	NUM
admet-1570	561	7	-	-	SYM
admet-1570	561	8	375	375	NUM
admet-1570	561	9	.	.	PUNCT
admet-1570	562	1	https://doi.org/10.1002/hep.1840050305	https://doi.org/10.1002/hep.1840050305	NOUN
admet-1570	562	2	.	.	PUNCT
admet-1570	563	1	[	[	X
admet-1570	563	2	43	43	NUM
admet-1570	563	3	]	]	X
admet-1570	563	4	m.	m.	NOUN
admet-1570	563	5	aktas	aktas	PROPN
admet-1570	563	6	,	,	PUNCT
admet-1570	563	7	h.p	h.p	PROPN
admet-1570	563	8	.	.	PROPN
admet-1570	563	9	lefebvre	lefebvre	PROPN
admet-1570	563	10	,	,	PUNCT
admet-1570	563	11	p.l	p.l	PROPN
admet-1570	563	12	.	.	PROPN
admet-1570	563	13	toutain	toutain	PROPN
admet-1570	563	14	,	,	PUNCT
admet-1570	563	15	j.p	j.p	PROPN
admet-1570	563	16	.	.	PROPN
admet-1570	563	17	braun	braun	PROPN
admet-1570	563	18	.	.	PUNCT
admet-1570	563	19	disposition	disposition	NOUN
admet-1570	563	20	of	of	ADP
admet-1570	563	21	creatine	creatine	PROPN
admet-1570	563	22	kinase	kinase	NOUN
admet-1570	563	23	activity	activity	NOUN
admet-1570	563	24	in	in	ADP
admet-1570	563	25	dog	dog	NOUN
admet-1570	563	26	plasma	plasma	NOUN
admet-1570	563	27	following	follow	VERB
admet-1570	563	28	intravenous	intravenous	ADJ
admet-1570	563	29	and	and	CCONJ
admet-1570	563	30	intramuscular	intramuscular	ADJ
admet-1570	563	31	injection	injection	NOUN
admet-1570	563	32	of	of	ADP
admet-1570	563	33	skeletal	skeletal	ADJ
admet-1570	563	34	muscle	muscle	NOUN
admet-1570	563	35	homogenates	homogenate	NOUN
admet-1570	563	36	.	.	PUNCT
admet-1570	564	1	j	j	PROPN
admet-1570	564	2	vet	vet	NOUN
admet-1570	564	3	pharmacol	pharmacol	PROPN
admet-1570	564	4	ther	ther	ADV
admet-1570	564	5	18	18	NUM
admet-1570	564	6	(	(	PUNCT
admet-1570	564	7	1995	1995	NUM
admet-1570	564	8	)	)	PUNCT
admet-1570	564	9	1	1	NUM
admet-1570	564	10	-	-	SYM
admet-1570	564	11	6	6	NUM
admet-1570	564	12	.	.	PUNCT
admet-1570	565	1	https://doi.org/10.1111/j.1365-2885.1995.tb00542.x	https://doi.org/10.1111/j.1365-2885.1995.tb00542.x	PROPN
admet-1570	565	2	.	.	PUNCT
admet-1570	566	1	[	[	X
admet-1570	566	2	44	44	NUM
admet-1570	566	3	]	]	PUNCT
admet-1570	566	4	m.	m.	NOUN
admet-1570	566	5	maekawa	maekawa	PROPN
admet-1570	566	6	.	.	PUNCT
admet-1570	567	1	lactate	lactate	NOUN
admet-1570	567	2	dehydrogenase	dehydrogenase	NOUN
admet-1570	567	3	isoenzymes	isoenzyme	NOUN
admet-1570	567	4	.	.	PUNCT
admet-1570	568	1	j	j	PROPN
admet-1570	568	2	chromatogr	chromatogr	PROPN
admet-1570	568	3	429	429	NUM
admet-1570	568	4	(	(	PUNCT
admet-1570	568	5	1988	1988	NUM
admet-1570	568	6	)	)	PUNCT
admet-1570	568	7	373	373	NUM
admet-1570	568	8	-	-	SYM
admet-1570	568	9	398	398	NUM
admet-1570	568	10	.	.	PUNCT
admet-1570	568	11	https://doi.org/10.1016/s0378-4347(00)83879-7	https://doi.org/10.1016/s0378-4347(00)83879-7	NOUN
admet-1570	568	12	.	.	PUNCT
admet-1570	569	1	[	[	X
admet-1570	569	2	45	45	NUM
admet-1570	569	3	]	]	X
admet-1570	569	4	s.a	s.a	PROPN
admet-1570	569	5	.	.	PROPN
admet-1570	569	6	johnson	johnson	PROPN
admet-1570	569	7	,	,	PUNCT
admet-1570	569	8	m.c	m.c	PROPN
admet-1570	569	9	.	.	PROPN
admet-1570	569	10	vander	vander	PROPN
admet-1570	569	11	straten	straten	ADV
admet-1570	569	12	,	,	PUNCT
admet-1570	569	13	j.a	j.a	PROPN
admet-1570	569	14	.	.	PROPN
admet-1570	569	15	parellada	parellada	PROPN
admet-1570	569	16	,	,	PUNCT
admet-1570	569	17	w.	w.	PROPN
admet-1570	569	18	schnakenberg	schnakenberg	PROPN
admet-1570	569	19	,	,	PUNCT
admet-1570	569	20	a.l	a.l	PROPN
admet-1570	569	21	.	.	PROPN
admet-1570	569	22	gest	gest	PROPN
admet-1570	569	23	.	.	PUNCT
admet-1570	570	1	thoracic	thoracic	NOUN
admet-1570	570	2	duct	duct	NOUN
admet-1570	570	3	function	function	NOUN
admet-1570	570	4	in	in	ADP
admet-1570	570	5	fetal	fetal	ADJ
admet-1570	570	6	,	,	PUNCT
admet-1570	570	7	newborn	newborn	ADJ
admet-1570	570	8	,	,	PUNCT
admet-1570	570	9	and	and	CCONJ
admet-1570	570	10	adult	adult	NOUN
admet-1570	570	11	sheep	sheep	NOUN
admet-1570	570	12	.	.	PUNCT
admet-1570	571	1	lymphology	lymphology	NOUN
admet-1570	571	2	29	29	NUM
admet-1570	571	3	(	(	PUNCT
admet-1570	571	4	1996	1996	NUM
admet-1570	571	5	)	)	PUNCT
admet-1570	571	6	50	50	NUM
admet-1570	571	7	-	-	SYM
admet-1570	571	8	56	56	NUM
admet-1570	571	9	.	.	PUNCT
admet-1570	571	10	https://www.ncbi.nlm.nih.gov/pubmed/8823726	https://www.ncbi.nlm.nih.gov/pubmed/8823726	X
admet-1570	571	11	.	.	PUNCT
admet-1570	572	1	[	[	X
admet-1570	572	2	46	46	NUM
admet-1570	572	3	]	]	X
admet-1570	572	4	e.	e.	PROPN
admet-1570	572	5	peters	peters	PROPN
admet-1570	572	6	,	,	PUNCT
admet-1570	572	7	j.	j.	PROPN
admet-1570	572	8	heuberger	heuberger	PROPN
admet-1570	572	9	,	,	PUNCT
admet-1570	572	10	r.	r.	PROPN
admet-1570	572	11	tiessen	tiessen	PROPN
admet-1570	572	12	,	,	PUNCT
admet-1570	572	13	a.	a.	PROPN
admet-1570	572	14	van	van	PROPN
admet-1570	572	15	elsas	elsas	PROPN
admet-1570	572	16	,	,	PUNCT
admet-1570	572	17	r.	r.	PROPN
admet-1570	572	18	masereeuw	masereeuw	PROPN
admet-1570	572	19	,	,	PUNCT
admet-1570	572	20	j.	j.	PROPN
admet-1570	572	21	arend	arend	PROPN
admet-1570	572	22	,	,	PUNCT
admet-1570	572	23	j.	j.	PROPN
admet-1570	572	24	stevens	stevens	PROPN
admet-1570	572	25	,	,	PUNCT
admet-1570	572	26	p.	p.	NOUN
admet-1570	572	27	pickkers	pickker	NOUN
admet-1570	572	28	.	.	PUNCT
admet-1570	573	1	pharmacokinetic	pharmacokinetic	ADJ
admet-1570	573	2	modeling	modeling	NOUN
admet-1570	573	3	and	and	CCONJ
admet-1570	573	4	dose	dose	NOUN
admet-1570	573	5	selection	selection	NOUN
admet-1570	573	6	in	in	ADP
admet-1570	573	7	a	a	DET
admet-1570	573	8	randomized	randomized	ADJ
admet-1570	573	9	,	,	PUNCT
admet-1570	573	10	double	double	ADJ
admet-1570	573	11	-	-	PUNCT
admet-1570	573	12	blind	blind	ADJ
admet-1570	573	13	,	,	PUNCT
admet-1570	573	14	placebo	placebo	NOUN
admet-1570	573	15	-	-	PUNCT
admet-1570	573	16	controlled	control	VERB
admet-1570	573	17	trial	trial	NOUN
admet-1570	573	18	of	of	ADP
admet-1570	573	19	a	a	DET
admet-1570	573	20	human	human	ADJ
admet-1570	573	21	recombinant	recombinant	ADJ
admet-1570	573	22	alkaline	alkaline	NOUN
admet-1570	573	23	phosphatase	phosphatase	NOUN
admet-1570	573	24	in	in	ADP
admet-1570	573	25	healthy	healthy	ADJ
admet-1570	573	26	volunteers	volunteer	NOUN
admet-1570	573	27	.	.	PUNCT
admet-1570	574	1	clin	clin	PROPN
admet-1570	574	2	pharmacokinet	pharmacokinet	PROPN
admet-1570	574	3	55	55	NUM
admet-1570	574	4	(	(	PUNCT
admet-1570	574	5	2016	2016	NUM
admet-1570	574	6	)	)	PUNCT
admet-1570	574	7	1227	1227	NUM
admet-1570	574	8	-	-	SYM
admet-1570	574	9	1237	1237	NUM
admet-1570	574	10	.	.	PUNCT
admet-1570	575	1	https://doi.org/10.1007/s40262-016-0399-y	https://doi.org/10.1007/s40262-016-0399-y	NOUN
admet-1570	575	2	.	.	PUNCT
admet-1570	576	1	[	[	X
admet-1570	576	2	47	47	NUM
admet-1570	576	3	]	]	PUNCT
admet-1570	576	4	t.	t.	PROPN
admet-1570	576	5	kiffer	kiffer	PROPN
admet-1570	576	6	-	-	PUNCT
admet-1570	576	7	moreira	moreira	PROPN
admet-1570	576	8	,	,	PUNCT
admet-1570	576	9	c.r	c.r	PROPN
admet-1570	576	10	.	.	PROPN
admet-1570	576	11	sheen	sheen	PROPN
admet-1570	576	12	,	,	PUNCT
admet-1570	576	13	k.c	k.c	PROPN
admet-1570	576	14	.	.	PROPN
admet-1570	576	15	gasque	gasque	PROPN
admet-1570	576	16	,	,	PUNCT
admet-1570	576	17	m.	m.	NOUN
admet-1570	576	18	bolean	bolean	PROPN
admet-1570	576	19	,	,	PUNCT
admet-1570	576	20	p.	p.	PROPN
admet-1570	576	21	ciancaglini	ciancaglini	PROPN
admet-1570	576	22	,	,	PUNCT
admet-1570	576	23	a.	a.	PROPN
admet-1570	576	24	van	van	PROPN
admet-1570	576	25	elsas	elsas	PROPN
admet-1570	576	26	,	,	PUNCT
admet-1570	576	27	m.f	m.f	PROPN
admet-1570	576	28	.	.	PUNCT
admet-1570	576	29	hoylaerts	hoylaert	NOUN
admet-1570	576	30	,	,	PUNCT
admet-1570	576	31	j.l	j.l	PROPN
admet-1570	576	32	.	.	PROPN
admet-1570	576	33	millan	millan	PROPN
admet-1570	576	34	.	.	PUNCT
admet-1570	577	1	catalytic	catalytic	ADJ
admet-1570	577	2	signature	signature	NOUN
admet-1570	577	3	of	of	ADP
admet-1570	577	4	a	a	DET
admet-1570	577	5	heat	heat	NOUN
admet-1570	577	6	-	-	PUNCT
admet-1570	577	7	stable	stable	ADJ
admet-1570	577	8	,	,	PUNCT
admet-1570	577	9	chimeric	chimeric	ADJ
admet-1570	577	10	human	human	ADJ
admet-1570	577	11	alkaline	alkaline	NOUN
admet-1570	577	12	phosphatase	phosphatase	NOUN
admet-1570	577	13	with	with	ADP
admet-1570	577	14	therapeutic	therapeutic	ADJ
admet-1570	577	15	potential	potential	NOUN
admet-1570	577	16	.	.	PUNCT
admet-1570	578	1	plos	plos	PROPN
admet-1570	578	2	one	one	NUM
admet-1570	578	3	9	9	NUM
admet-1570	578	4	(	(	PUNCT
admet-1570	578	5	2014	2014	NUM
admet-1570	578	6	)	)	PUNCT
admet-1570	578	7	e89374	e89374	NOUN
admet-1570	578	8	.	.	PUNCT
admet-1570	579	1	https://doi.org/10.1371/journal.pone.0089374	https://doi.org/10.1371/journal.pone.0089374	PROPN
admet-1570	579	2	.	.	PUNCT
admet-1570	580	1	[	[	X
admet-1570	580	2	48	48	NUM
admet-1570	580	3	]	]	PUNCT
admet-1570	580	4	p.	p.	NOUN
admet-1570	580	5	pickkers	pickker	NOUN
admet-1570	580	6	,	,	PUNCT
admet-1570	580	7	f.	f.	PROPN
admet-1570	580	8	snellen	snellen	PROPN
admet-1570	580	9	,	,	PUNCT
admet-1570	580	10	p.	p.	NOUN
admet-1570	580	11	rogiers	rogier	NOUN
admet-1570	580	12	,	,	PUNCT
admet-1570	580	13	j.	j.	PROPN
admet-1570	580	14	bakker	bakker	PROPN
admet-1570	580	15	,	,	PUNCT
admet-1570	580	16	p.	p.	PROPN
admet-1570	580	17	jorens	jorens	PROPN
admet-1570	580	18	,	,	PUNCT
admet-1570	580	19	j.	j.	PROPN
admet-1570	580	20	meulenbelt	meulenbelt	PROPN
admet-1570	580	21	,	,	PUNCT
admet-1570	580	22	h.	h.	PROPN
admet-1570	580	23	spapen	spapen	PROPN
admet-1570	580	24	,	,	PUNCT
admet-1570	580	25	j.e	j.e	PROPN
admet-1570	580	26	.	.	PROPN
admet-1570	580	27	tulleken	tulleken	PROPN
admet-1570	580	28	,	,	PUNCT
admet-1570	580	29	r.	r.	PROPN
admet-1570	580	30	lins	lins	PROPN
admet-1570	580	31	,	,	PUNCT
admet-1570	580	32	s.	s.	PROPN
admet-1570	580	33	ramael	ramael	PROPN
admet-1570	580	34	,	,	PUNCT
admet-1570	580	35	m.	m.	NOUN
admet-1570	580	36	bulitta	bulitta	PROPN
admet-1570	580	37	,	,	PUNCT
admet-1570	580	38	j.g	j.g	PROPN
admet-1570	580	39	.	.	PROPN
admet-1570	580	40	van	van	PROPN
admet-1570	580	41	der	der	PROPN
admet-1570	580	42	hoeven	hoeven	PROPN
admet-1570	580	43	.	.	PUNCT
admet-1570	581	1	clinical	clinical	ADJ
admet-1570	581	2	pharmacology	pharmacology	NOUN
admet-1570	581	3	of	of	ADP
admet-1570	581	4	exogenously	exogenously	ADV
admet-1570	581	5	administered	administer	VERB
admet-1570	581	6	alkaline	alkaline	NOUN
admet-1570	581	7	phosphatase	phosphatase	NOUN
admet-1570	581	8	.	.	PUNCT
admet-1570	582	1	eur	eur	PROPN
admet-1570	582	2	j	j	PROPN
admet-1570	582	3	clin	clin	PROPN
admet-1570	582	4	pharmacol	pharmacol	PROPN
admet-1570	582	5	65	65	NUM
admet-1570	582	6	(	(	PUNCT
admet-1570	582	7	2009	2009	NUM
admet-1570	582	8	)	)	PUNCT
admet-1570	582	9	393	393	NUM
admet-1570	582	10	-	-	SYM
admet-1570	582	11	402	402	NUM
admet-1570	582	12	.	.	PUNCT
admet-1570	582	13	https://doi.org/10.1007/s00228-008-0591-6	https://doi.org/10.1007/s00228-008-0591-6	NUM
admet-1570	582	14	.	.	PUNCT
admet-1570	583	1	[	[	X
admet-1570	583	2	49	49	NUM
admet-1570	583	3	]	]	X
admet-1570	583	4	e.	e.	PROPN
admet-1570	583	5	blom	blom	PROPN
admet-1570	583	6	,	,	PUNCT
admet-1570	583	7	m.m	m.m	PROPN
admet-1570	583	8	.	.	PROPN
admet-1570	583	9	ali	ali	PROPN
admet-1570	583	10	,	,	PUNCT
admet-1570	583	11	b.	b.	PROPN
admet-1570	583	12	mortensen	mortensen	PROPN
admet-1570	583	13	,	,	PUNCT
admet-1570	583	14	n.e	n.e	PROPN
admet-1570	583	15	.	.	PROPN
admet-1570	583	16	huseby	huseby	PROPN
admet-1570	583	17	.	.	PUNCT
admet-1570	584	1	elimination	elimination	NOUN
admet-1570	584	2	of	of	ADP
admet-1570	584	3	alkaline	alkaline	NOUN
admet-1570	584	4	phosphatases	phosphatase	NOUN
admet-1570	584	5	from	from	ADP
admet-1570	584	6	circulation	circulation	NOUN
admet-1570	584	7	by	by	ADP
admet-1570	584	8	the	the	DET
admet-1570	584	9	galactose	galactose	ADJ
admet-1570	584	10	receptor	receptor	NOUN
admet-1570	584	11	.	.	PUNCT
admet-1570	585	1	different	different	ADJ
admet-1570	585	2	isoforms	isoform	NOUN
admet-1570	585	3	are	be	AUX
admet-1570	585	4	cleared	clear	VERB
admet-1570	585	5	at	at	ADP
admet-1570	585	6	various	various	ADJ
admet-1570	585	7	rates	rate	NOUN
admet-1570	585	8	.	.	PUNCT
admet-1570	586	1	clin	clin	PROPN
admet-1570	586	2	chim	chim	PROPN
admet-1570	586	3	acta	acta	PROPN
admet-1570	586	4	270	270	NUM
admet-1570	586	5	(	(	PUNCT
admet-1570	586	6	1998	1998	NUM
admet-1570	586	7	)	)	PUNCT
admet-1570	586	8	125137	125137	NUM
admet-1570	586	9	.	.	PUNCT
admet-1570	587	1	https://doi.org/10.1016/s0009-8981(97)00217-9	https://doi.org/10.1016/s0009-8981(97)00217-9	PROPN
admet-1570	587	2	.	.	PUNCT
admet-1570	588	1	[	[	X
admet-1570	588	2	50	50	NUM
admet-1570	588	3	]	]	SYM
admet-1570	588	4	f.g	f.g	NOUN
admet-1570	588	5	.	.	PROPN
admet-1570	588	6	russel	russel	PROPN
admet-1570	588	7	,	,	PUNCT
admet-1570	588	8	j.g	j.g	PROPN
admet-1570	588	9	.	.	PROPN
admet-1570	588	10	weitering	weitering	PROPN
admet-1570	588	11	,	,	PUNCT
admet-1570	588	12	r.	r.	PROPN
admet-1570	588	13	oosting	oosting	PROPN
admet-1570	588	14	,	,	PUNCT
admet-1570	588	15	g.m	g.m	PROPN
admet-1570	588	16	.	.	PROPN
admet-1570	588	17	groothuis	groothuis	PROPN
admet-1570	588	18	,	,	PUNCT
admet-1570	588	19	m.j	m.j	PROPN
admet-1570	588	20	.	.	PROPN
admet-1570	588	21	hardonk	hardonk	PROPN
admet-1570	588	22	,	,	PUNCT
admet-1570	588	23	d.k	d.k	PROPN
admet-1570	588	24	.	.	PROPN
admet-1570	588	25	meijer	meijer	PROPN
admet-1570	588	26	.	.	PUNCT
admet-1570	589	1	influence	influence	NOUN
admet-1570	589	2	of	of	ADP
admet-1570	589	3	taurocholate	taurocholate	NOUN
admet-1570	589	4	on	on	ADP
admet-1570	589	5	hepatic	hepatic	ADJ
admet-1570	589	6	clearance	clearance	NOUN
admet-1570	589	7	and	and	CCONJ
admet-1570	589	8	biliary	biliary	NOUN
admet-1570	589	9	excretion	excretion	NOUN
admet-1570	589	10	of	of	ADP
admet-1570	589	11	asialo	asialo	PRON
admet-1570	589	12	intestinal	intestinal	ADJ
admet-1570	589	13	alkaline	alkaline	NOUN
admet-1570	589	14	phosphatase	phosphatase	NOUN
admet-1570	589	15	in	in	ADP
admet-1570	589	16	the	the	DET
admet-1570	589	17	rat	rat	NOUN
admet-1570	589	18	in	in	ADP
admet-1570	589	19	vivo	vivo	NOUN
admet-1570	589	20	and	and	CCONJ
admet-1570	589	21	in	in	ADP
admet-1570	589	22	isolated	isolated	ADJ
admet-1570	589	23	perfused	perfused	ADJ
admet-1570	589	24	rat	rat	NOUN
admet-1570	589	25	liver	liver	NOUN
admet-1570	589	26	.	.	PUNCT
admet-1570	590	1	gastroenterology	gastroenterology	NOUN
admet-1570	590	2	85	85	NUM
admet-1570	590	3	(	(	PUNCT
admet-1570	590	4	1983	1983	NUM
admet-1570	590	5	)	)	PUNCT
admet-1570	590	6	225	225	NUM
admet-1570	590	7	-	-	SYM
admet-1570	590	8	234	234	NUM
admet-1570	590	9	.	.	PUNCT
admet-1570	590	10	https://www.ncbi.nlm.nih.gov/pubmed/6862151	https://www.ncbi.nlm.nih.gov/pubmed/6862151	NUM
admet-1570	590	11	.	.	PUNCT
admet-1570	591	1	[	[	X
admet-1570	591	2	51	51	NUM
admet-1570	591	3	]	]	X
admet-1570	591	4	h.b	h.b	PROPN
admet-1570	591	5	.	.	PROPN
admet-1570	591	6	scholtens	scholtens	PROPN
admet-1570	591	7	,	,	PUNCT
admet-1570	591	8	m.j	m.j	PROPN
admet-1570	591	9	.	.	PROPN
admet-1570	591	10	hardonk	hardonk	PROPN
admet-1570	591	11	,	,	PUNCT
admet-1570	591	12	d.k	d.k	PROPN
admet-1570	591	13	.	.	PROPN
admet-1570	591	14	meijer	meijer	PROPN
admet-1570	591	15	.	.	PUNCT
admet-1570	592	1	a	a	DET
admet-1570	592	2	kinetic	kinetic	ADJ
admet-1570	592	3	study	study	NOUN
admet-1570	592	4	of	of	ADP
admet-1570	592	5	hepatic	hepatic	ADJ
admet-1570	592	6	uptake	uptake	NOUN
admet-1570	592	7	of	of	ADP
admet-1570	592	8	canine	canine	ADJ
admet-1570	592	9	intestinal	intestinal	ADJ
admet-1570	592	10	alkaline	alkaline	NOUN
admet-1570	592	11	phosphatase	phosphatase	NOUN
admet-1570	592	12	in	in	ADP
admet-1570	592	13	the	the	DET
admet-1570	592	14	rat	rat	NOUN
admet-1570	592	15	.	.	PROPN
admet-1570	592	16	liver	liver	PROPN
admet-1570	592	17	2	2	NUM
admet-1570	592	18	(	(	PUNCT
admet-1570	592	19	1982	1982	NUM
admet-1570	592	20	)	)	PUNCT
admet-1570	592	21	1	1	NUM
admet-1570	592	22	-	-	SYM
admet-1570	592	23	13	13	NUM
admet-1570	592	24	.	.	PUNCT
admet-1570	593	1	https://doi.org/10.1111/j.1600-0676.1982.tb00172.x	https://doi.org/10.1111/j.1600-0676.1982.tb00172.x	NOUN
admet-1570	593	2	.	.	PUNCT
admet-1570	594	1	[	[	X
admet-1570	594	2	52	52	NUM
admet-1570	594	3	]	]	X
admet-1570	594	4	g.p	g.p	PROPN
admet-1570	594	5	.	.	PROPN
admet-1570	594	6	young	young	PROPN
admet-1570	594	7	,	,	PUNCT
admet-1570	594	8	i.s	i.s	PROPN
admet-1570	594	9	.	.	PROPN
admet-1570	594	10	rose	rose	PROPN
admet-1570	594	11	,	,	PUNCT
admet-1570	594	12	s.	s.	PROPN
admet-1570	594	13	cropper	cropper	PROPN
admet-1570	594	14	,	,	PUNCT
admet-1570	594	15	s.	s.	PROPN
admet-1570	594	16	seetharam	seetharam	PROPN
admet-1570	594	17	,	,	PUNCT
admet-1570	594	18	d.h	d.h	PROPN
admet-1570	594	19	.	.	PROPN
admet-1570	594	20	alpers	alper	NOUN
admet-1570	594	21	.	.	PUNCT
admet-1570	595	1	hepatic	hepatic	ADJ
admet-1570	595	2	clearance	clearance	NOUN
admet-1570	595	3	of	of	ADP
admet-1570	595	4	rat	rat	NOUN
admet-1570	595	5	plasma	plasma	NOUN
admet-1570	595	6	intestinal	intestinal	ADJ
admet-1570	595	7	alkaline	alkaline	NOUN
admet-1570	595	8	phosphatase	phosphatase	NOUN
admet-1570	595	9	.	.	PUNCT
admet-1570	596	1	am	be	AUX
admet-1570	596	2	j	j	PROPN
admet-1570	596	3	physiol	physiol	PROPN
admet-1570	596	4	247	247	NUM
admet-1570	596	5	(	(	PUNCT
admet-1570	596	6	1984	1984	NUM
admet-1570	596	7	)	)	PUNCT
admet-1570	596	8	g419	g419	PROPN
admet-1570	596	9	-	-	PUNCT
admet-1570	596	10	426	426	NUM
admet-1570	596	11	.	.	PUNCT
admet-1570	597	1	https://doi.org/10.1152/ajpgi.1984.247.4.g419	https://doi.org/10.1152/ajpgi.1984.247.4.g419	X
admet-1570	597	2	.	.	PUNCT
admet-1570	598	1	[	[	X
admet-1570	598	2	53	53	NUM
admet-1570	598	3	]	]	X
admet-1570	598	4	u.	u.	PROPN
admet-1570	598	5	domar	domar	PROPN
admet-1570	598	6	,	,	PUNCT
admet-1570	598	7	f.	f.	PROPN
admet-1570	598	8	karpe	karpe	PROPN
admet-1570	598	9	,	,	PUNCT
admet-1570	598	10	a.	a.	NOUN
admet-1570	598	11	hamsten	hamsten	PROPN
admet-1570	598	12	,	,	PUNCT
admet-1570	598	13	t.	t.	PROPN
admet-1570	598	14	stigbrand	stigbrand	PROPN
admet-1570	598	15	,	,	PUNCT
admet-1570	598	16	t.	t.	PROPN
admet-1570	598	17	olivecrona	olivecrona	PROPN
admet-1570	598	18	.	.	PUNCT
admet-1570	599	1	human	human	ADJ
admet-1570	599	2	intestinal	intestinal	ADJ
admet-1570	599	3	alkaline	alkaline	NOUN
admet-1570	599	4	phosphatase	phosphatase	NOUN
admet-1570	599	5	-	-	PUNCT
admet-1570	599	6	release	release	NOUN
admet-1570	599	7	to	to	ADP
admet-1570	599	8	the	the	DET
admet-1570	599	9	blood	blood	NOUN
admet-1570	599	10	is	be	AUX
admet-1570	599	11	linked	link	VERB
admet-1570	599	12	to	to	ADP
admet-1570	599	13	lipid	lipid	NOUN
admet-1570	599	14	absorption	absorption	NOUN
admet-1570	599	15	,	,	PUNCT
admet-1570	599	16	but	but	CCONJ
admet-1570	599	17	removal	removal	NOUN
admet-1570	599	18	from	from	ADP
admet-1570	599	19	the	the	DET
admet-1570	599	20	blood	blood	NOUN
admet-1570	599	21	is	be	AUX
admet-1570	599	22	not	not	PART
admet-1570	599	23	linked	link	VERB
admet-1570	599	24	to	to	ADP
admet-1570	599	25	lipoprotein	lipoprotein	ADJ
admet-1570	599	26	clearance	clearance	NOUN
admet-1570	599	27	.	.	PUNCT
admet-1570	600	1	eur	eur	PROPN
admet-1570	600	2	j	j	PROPN
admet-1570	600	3	clin	clin	PROPN
admet-1570	600	4	invest	invest	VERB
admet-1570	600	5	23	23	NUM
admet-1570	600	6	(	(	PUNCT
admet-1570	600	7	1993	1993	NUM
admet-1570	600	8	)	)	PUNCT
admet-1570	600	9	753	753	NUM
admet-1570	600	10	-	-	SYM
admet-1570	600	11	760	760	NUM
admet-1570	600	12	.	.	PUNCT
admet-1570	601	1	https://doi.org/10.1111/j.1365-2362.1993.tb01296.x	https://doi.org/10.1111/j.1365-2362.1993.tb01296.x	PROPN
admet-1570	601	2	.	.	PROPN
admet-1570	601	3	https://doi.org/10.5599/admet.1570	https://doi.org/10.5599/admet.1570	PROPN
admet-1570	602	1	https://www.ncbi.nlm.nih.gov/pubmed/2820961	https://www.ncbi.nlm.nih.gov/pubmed/2820961	X
admet-1570	603	1	https://www.ncbi.nlm.nih.gov/pubmed/2820961	https://www.ncbi.nlm.nih.gov/pubmed/2820961	PROPN
admet-1570	603	2	https://www.ncbi.nlm.nih.gov/pubmed/13945478	https://www.ncbi.nlm.nih.gov/pubmed/13945478	NUM
admet-1570	603	3	https://doi.org/10.1007/bf00581360	https://doi.org/10.1007/bf00581360	PROPN
admet-1570	603	4	https://doi.org/10.3181/00379727-106-26310	https://doi.org/10.3181/00379727-106-26310	PROPN
admet-1570	603	5	https://doi.org/10.3181/00379727-106-26310	https://doi.org/10.3181/00379727-106-26310	PROPN
admet-1570	603	6	https://doi.org/10.1002/hep.1840050305	https://doi.org/10.1002/hep.1840050305	PROPN
admet-1570	603	7	https://doi.org/10.1111/j.1365-2885.1995.tb00542.x	https://doi.org/10.1111/j.1365-2885.1995.tb00542.x	PROPN
admet-1570	603	8	https://doi.org/10.1016/s0378-4347(00)83879-7	https://doi.org/10.1016/s0378-4347(00)83879-7	PROPN
admet-1570	603	9	https://doi.org/10.1016/s0378-4347(00)83879-7	https://doi.org/10.1016/s0378-4347(00)83879-7	NOUN
admet-1570	603	10	https://www.ncbi.nlm.nih.gov/pubmed/8823726	https://www.ncbi.nlm.nih.gov/pubmed/8823726	X
admet-1570	603	11	https://www.ncbi.nlm.nih.gov/pubmed/8823726	https://www.ncbi.nlm.nih.gov/pubmed/8823726	X
admet-1570	603	12	https://doi.org/10.1007/s40262-016-0399-y	https://doi.org/10.1007/s40262-016-0399-y	PROPN
admet-1570	603	13	https://doi.org/10.1371/journal.pone.0089374	https://doi.org/10.1371/journal.pone.0089374	PROPN
admet-1570	604	1	https://doi.org/10.1007/s00228-008-0591-6	https://doi.org/10.1007/s00228-008-0591-6	NUM
admet-1570	604	2	https://doi.org/10.1016/s0009-8981(97)00217-9	https://doi.org/10.1016/s0009-8981(97)00217-9	NOUN
admet-1570	604	3	https://www.ncbi.nlm.nih.gov/pubmed/6862151	https://www.ncbi.nlm.nih.gov/pubmed/6862151	PRON
admet-1570	604	4	https://www.ncbi.nlm.nih.gov/pubmed/6862151	https://www.ncbi.nlm.nih.gov/pubmed/6862151	PROPN
admet-1570	605	1	https://doi.org/10.1111/j.1600-0676.1982.tb00172.x	https://doi.org/10.1111/j.1600-0676.1982.tb00172.x	PROPN
admet-1570	605	2	https://doi.org/10.1152/ajpgi.1984.247.4.g419	https://doi.org/10.1152/ajpgi.1984.247.4.g419	X
admet-1570	606	1	https://doi.org/10.1152/ajpgi.1984.247.4.g419	https://doi.org/10.1152/ajpgi.1984.247.4.g419	X
admet-1570	606	2	https://doi.org/10.1111/j.1365-2362.1993.tb01296.x	https://doi.org/10.1111/j.1365-2362.1993.tb01296.x	PROPN
admet-1570	606	3	d.g	d.g	PROPN
admet-1570	606	4	.	.	PROPN
admet-1570	606	5	levitt	levitt	PROPN
admet-1570	606	6	and	and	CCONJ
admet-1570	606	7	m.d	m.d	PROPN
admet-1570	606	8	.	.	PROPN
admet-1570	606	9	levitt	levitt	PROPN
admet-1570	606	10	admet	admet	PROPN
admet-1570	606	11	&	&	CCONJ
admet-1570	606	12	dmpk	dmpk	PROPN
admet-1570	606	13	11(1	11(1	NUM
admet-1570	606	14	)	)	PUNCT
admet-1570	606	15	(	(	PUNCT
admet-1570	606	16	2023	2023	NUM
admet-1570	606	17	)	)	PUNCT
admet-1570	606	18	57	57	NUM
admet-1570	606	19	-	-	SYM
admet-1570	606	20	80	80	NUM
admet-1570	606	21	80	80	NUM
admet-1570	606	22	[	[	X
admet-1570	606	23	54	54	NUM
admet-1570	606	24	]	]	X
admet-1570	606	25	u.	u.	PROPN
admet-1570	606	26	sharma	sharma	PROPN
admet-1570	606	27	,	,	PUNCT
admet-1570	606	28	d.	d.	PROPN
admet-1570	606	29	pal	pal	PROPN
admet-1570	606	30	,	,	PUNCT
admet-1570	606	31	r.	r.	PROPN
admet-1570	606	32	prasad	prasad	PROPN
admet-1570	606	33	.	.	PUNCT
admet-1570	607	1	alkaline	alkaline	PROPN
admet-1570	607	2	phosphatase	phosphatase	NOUN
admet-1570	607	3	:	:	PUNCT
admet-1570	607	4	an	an	DET
admet-1570	607	5	overview	overview	NOUN
admet-1570	607	6	.	.	PUNCT
admet-1570	608	1	indian	indian	PROPN
admet-1570	608	2	j	j	PROPN
admet-1570	608	3	clin	clin	PROPN
admet-1570	608	4	biochem	biochem	PROPN
admet-1570	608	5	29	29	NUM
admet-1570	608	6	(	(	PUNCT
admet-1570	608	7	2014	2014	NUM
admet-1570	608	8	)	)	PUNCT
admet-1570	608	9	269278	269278	NUM
admet-1570	608	10	.	.	PUNCT
admet-1570	609	1	https://doi.org/10.1007/s12291-013-0408-y	https://doi.org/10.1007/s12291-013-0408-y	NOUN
admet-1570	609	2	.	.	PUNCT
admet-1570	610	1	[	[	X
admet-1570	610	2	55	55	NUM
admet-1570	610	3	]	]	PUNCT
admet-1570	610	4	t.	t.	PROPN
admet-1570	610	5	endo	endo	PROPN
admet-1570	610	6	,	,	PUNCT
admet-1570	610	7	h.	h.	PROPN
admet-1570	610	8	ohbayashi	ohbayashi	PROPN
admet-1570	610	9	,	,	PUNCT
admet-1570	610	10	y.	y.	PROPN
admet-1570	610	11	hayashi	hayashi	PROPN
admet-1570	610	12	,	,	PUNCT
admet-1570	610	13	y.	y.	PROPN
admet-1570	610	14	ikehara	ikehara	PROPN
admet-1570	610	15	,	,	PUNCT
admet-1570	610	16	n.	n.	PROPN
admet-1570	610	17	kochibe	kochibe	PROPN
admet-1570	610	18	,	,	PUNCT
admet-1570	610	19	a.	a.	PROPN
admet-1570	610	20	kobata	kobata	PROPN
admet-1570	610	21	.	.	PUNCT
admet-1570	611	1	structural	structural	ADJ
admet-1570	611	2	study	study	NOUN
admet-1570	611	3	on	on	ADP
admet-1570	611	4	the	the	DET
admet-1570	611	5	carbohydrate	carbohydrate	ADJ
admet-1570	611	6	moiety	moiety	NOUN
admet-1570	611	7	of	of	ADP
admet-1570	611	8	human	human	ADJ
admet-1570	611	9	placental	placental	ADJ
admet-1570	611	10	alkaline	alkaline	NOUN
admet-1570	611	11	phosphatase	phosphatase	NOUN
admet-1570	611	12	.	.	PUNCT
admet-1570	612	1	j	j	PROPN
admet-1570	612	2	biochem	biochem	PROPN
admet-1570	612	3	103	103	NUM
admet-1570	612	4	(	(	PUNCT
admet-1570	612	5	1988	1988	NUM
admet-1570	612	6	)	)	PUNCT
admet-1570	612	7	182	182	NUM
admet-1570	612	8	-	-	SYM
admet-1570	612	9	187	187	NUM
admet-1570	612	10	.	.	PUNCT
admet-1570	613	1	https://doi.org/10.1093/oxfordjournals.jbchem.a122228	https://doi.org/10.1093/oxfordjournals.jbchem.a122228	PROPN
admet-1570	613	2	.	.	PUNCT
admet-1570	614	1	[	[	X
admet-1570	614	2	56	56	NUM
admet-1570	614	3	]	]	X
admet-1570	614	4	j.s	j.s	PROPN
admet-1570	614	5	.	.	PROPN
admet-1570	614	6	clubb	clubb	PROPN
admet-1570	614	7	,	,	PUNCT
admet-1570	614	8	f.c	f.c	PROPN
admet-1570	614	9	.	.	PROPN
admet-1570	614	10	neale	neale	PROPN
admet-1570	614	11	,	,	PUNCT
admet-1570	614	12	s.	s.	PROPN
admet-1570	614	13	posen	posen	PROPN
admet-1570	614	14	.	.	PUNCT
admet-1570	615	1	the	the	DET
admet-1570	615	2	behavior	behavior	NOUN
admet-1570	615	3	of	of	ADP
admet-1570	615	4	infused	infuse	VERB
admet-1570	615	5	human	human	ADJ
admet-1570	615	6	placental	placental	ADJ
admet-1570	615	7	alkaline	alkaline	NOUN
admet-1570	615	8	phosphatase	phosphatase	NOUN
admet-1570	615	9	in	in	ADP
admet-1570	615	10	human	human	ADJ
admet-1570	615	11	subjects	subject	NOUN
admet-1570	615	12	.	.	PUNCT
admet-1570	616	1	j	j	PROPN
admet-1570	616	2	lab	lab	PROPN
admet-1570	616	3	clin	clin	PROPN
admet-1570	616	4	med	me	VERB
admet-1570	616	5	66	66	NUM
admet-1570	616	6	(	(	PUNCT
admet-1570	616	7	1965	1965	NUM
admet-1570	616	8	)	)	PUNCT
admet-1570	616	9	493	493	NUM
admet-1570	616	10	-	-	SYM
admet-1570	616	11	507	507	NUM
admet-1570	616	12	.	.	PUNCT
admet-1570	617	1	https://www.ncbi.nlm.nih.gov/pubmed/5835974	https://www.ncbi.nlm.nih.gov/pubmed/5835974	X
admet-1570	617	2	.	.	PUNCT
admet-1570	618	1	[	[	X
admet-1570	618	2	57	57	NUM
admet-1570	618	3	]	]	X
admet-1570	618	4	m.d	m.d	PROPN
admet-1570	618	5	.	.	PROPN
admet-1570	618	6	levitt	levitt	PROPN
admet-1570	618	7	,	,	PUNCT
admet-1570	618	8	m.	m.	NOUN
admet-1570	618	9	rapoport	rapoport	PROPN
admet-1570	618	10	,	,	PUNCT
admet-1570	618	11	s.r	s.r	PROPN
admet-1570	618	12	.	.	PROPN
admet-1570	618	13	cooperband	cooperband	NOUN
admet-1570	618	14	.	.	PUNCT
admet-1570	619	1	the	the	DET
admet-1570	619	2	renal	renal	ADJ
admet-1570	619	3	clearance	clearance	NOUN
admet-1570	619	4	of	of	ADP
admet-1570	619	5	amylase	amylase	NOUN
admet-1570	619	6	in	in	ADP
admet-1570	619	7	renal	renal	ADJ
admet-1570	619	8	insufficiency	insufficiency	NOUN
admet-1570	619	9	,	,	PUNCT
admet-1570	619	10	acute	acute	PROPN
admet-1570	619	11	pancreatitis	pancreatitis	PROPN
admet-1570	619	12	,	,	PUNCT
admet-1570	619	13	and	and	CCONJ
admet-1570	619	14	macroamylasemia	macroamylasemia	NOUN
admet-1570	619	15	.	.	PUNCT
admet-1570	620	1	ann	ann	PROPN
admet-1570	620	2	intern	intern	PROPN
admet-1570	620	3	med	me	VERB
admet-1570	620	4	71	71	NUM
admet-1570	620	5	(	(	PUNCT
admet-1570	620	6	1969	1969	NUM
admet-1570	620	7	)	)	PUNCT
admet-1570	620	8	919	919	NUM
admet-1570	620	9	-	-	SYM
admet-1570	620	10	925	925	NUM
admet-1570	620	11	.	.	PUNCT
admet-1570	621	1	https://doi.org/10.7326/0003-4819-71-5-919	https://doi.org/10.7326/0003-4819-71-5-919	PROPN
admet-1570	621	2	.	.	PUNCT
admet-1570	622	1	[	[	X
admet-1570	622	2	58	58	NUM
admet-1570	622	3	]	]	X
admet-1570	622	4	v.l	v.l	PROPN
admet-1570	622	5	.	.	PROPN
admet-1570	622	6	royse	royse	PROPN
admet-1570	622	7	,	,	PUNCT
admet-1570	622	8	d.m	d.m	PROPN
admet-1570	622	9	.	.	PUNCT
admet-1570	622	10	jensen	jensen	PROPN
admet-1570	622	11	,	,	PUNCT
admet-1570	622	12	h.l	h.l	PROPN
admet-1570	622	13	.	.	PROPN
admet-1570	622	14	corwin	corwin	PROPN
admet-1570	622	15	.	.	PUNCT
admet-1570	623	1	pancreatic	pancreatic	ADJ
admet-1570	623	2	enzymes	enzyme	NOUN
admet-1570	623	3	in	in	ADP
admet-1570	623	4	chronic	chronic	ADJ
admet-1570	623	5	renal	renal	ADJ
admet-1570	623	6	failure	failure	NOUN
admet-1570	623	7	.	.	PUNCT
admet-1570	624	1	arch	arch	ADJ
admet-1570	624	2	intern	intern	NOUN
admet-1570	624	3	med	me	VERB
admet-1570	624	4	147	147	NUM
admet-1570	624	5	(	(	PUNCT
admet-1570	624	6	1987	1987	NUM
admet-1570	624	7	)	)	PUNCT
admet-1570	624	8	537	537	NUM
admet-1570	624	9	-	-	SYM
admet-1570	624	10	539	539	NUM
admet-1570	624	11	.	.	PUNCT
admet-1570	625	1	https://www.ncbi.nlm.nih.gov/pubmed/2435254	https://www.ncbi.nlm.nih.gov/pubmed/2435254	X
admet-1570	625	2	.	.	PUNCT
admet-1570	626	1	[	[	X
admet-1570	626	2	59	59	NUM
admet-1570	626	3	]	]	X
admet-1570	626	4	m.d	m.d	PROPN
admet-1570	626	5	.	.	PROPN
admet-1570	626	6	levitt	levitt	PROPN
admet-1570	626	7	,	,	PUNCT
admet-1570	626	8	s.m	s.m	PROPN
admet-1570	626	9	.	.	PROPN
admet-1570	626	10	hapak	hapak	PROPN
admet-1570	626	11	,	,	PUNCT
admet-1570	626	12	d.g	d.g	PROPN
admet-1570	626	13	.	.	PROPN
admet-1570	626	14	levitt	levitt	PROPN
admet-1570	626	15	.	.	PUNCT
admet-1570	627	1	alkaline	alkaline	ADJ
admet-1570	627	2	phosphatase	phosphatase	NOUN
admet-1570	627	3	pathophysiology	pathophysiology	NOUN
admet-1570	627	4	with	with	ADP
admet-1570	627	5	emphasis	emphasis	NOUN
admet-1570	627	6	on	on	ADP
admet-1570	627	7	the	the	DET
admet-1570	627	8	seldom	seldom	ADV
admet-1570	627	9	-	-	PUNCT
admet-1570	627	10	discussed	discuss	VERB
admet-1570	627	11	role	role	NOUN
admet-1570	627	12	of	of	ADP
admet-1570	627	13	defective	defective	ADJ
admet-1570	627	14	elimination	elimination	NOUN
admet-1570	627	15	in	in	ADP
admet-1570	627	16	unexplained	unexplained	ADJ
admet-1570	627	17	elevations	elevation	NOUN
admet-1570	627	18	of	of	ADP
admet-1570	627	19	serum	serum	NOUN
admet-1570	627	20	alp	alp	PROPN
admet-1570	627	21	a	a	DET
admet-1570	627	22	case	case	NOUN
admet-1570	627	23	report	report	NOUN
admet-1570	627	24	and	and	CCONJ
admet-1570	627	25	literature	literature	PROPN
admet-1570	627	26	review	review	PROPN
admet-1570	627	27	.	.	PUNCT
admet-1570	628	1	clin	clin	PROPN
admet-1570	628	2	exp	exp	PROPN
admet-1570	628	3	gastroenterol	gastroenterol	PROPN
admet-1570	628	4	15	15	NUM
admet-1570	628	5	(	(	PUNCT
admet-1570	628	6	2022	2022	NUM
admet-1570	628	7	)	)	PUNCT
admet-1570	628	8	41	41	NUM
admet-1570	628	9	-	-	SYM
admet-1570	628	10	49	49	NUM
admet-1570	628	11	.	.	PUNCT
admet-1570	629	1	https://doi.org/10.2147/ceg.s345531	https://doi.org/10.2147/ceg.s345531	NOUN
admet-1570	629	2	.	.	PUNCT
admet-1570	630	1	[	[	X
admet-1570	630	2	60	60	NUM
admet-1570	630	3	]	]	PUNCT
admet-1570	630	4	k.	k.	PROPN
admet-1570	630	5	goswami	goswami	PROPN
admet-1570	630	6	,	,	PUNCT
admet-1570	630	7	d.n	d.n	PROPN
admet-1570	630	8	.	.	PROPN
admet-1570	630	9	nandakumar	nandakumar	PROPN
admet-1570	630	10	,	,	PUNCT
admet-1570	630	11	b.c	b.c	PROPN
admet-1570	630	12	.	.	PROPN
admet-1570	630	13	koner	koner	PROPN
admet-1570	630	14	,	,	PUNCT
admet-1570	630	15	z.	z.	PROPN
admet-1570	630	16	bobby	bobby	PROPN
admet-1570	630	17	,	,	PUNCT
admet-1570	630	18	s.k	s.k	PROPN
admet-1570	630	19	.	.	PROPN
admet-1570	630	20	sen	sen	PROPN
admet-1570	630	21	.	.	PROPN
admet-1570	630	22	oxidative	oxidative	ADJ
admet-1570	630	23	changes	change	NOUN
admet-1570	630	24	and	and	CCONJ
admet-1570	630	25	desialylation	desialylation	NOUN
admet-1570	630	26	of	of	ADP
admet-1570	630	27	serum	serum	NOUN
admet-1570	630	28	proteins	protein	NOUN
admet-1570	630	29	in	in	ADP
admet-1570	630	30	hyperthyroidism	hyperthyroidism	NOUN
admet-1570	630	31	.	.	PUNCT
admet-1570	631	1	clin	clin	PROPN
admet-1570	631	2	chim	chim	PROPN
admet-1570	631	3	acta	acta	PROPN
admet-1570	631	4	337	337	NUM
admet-1570	631	5	(	(	PUNCT
admet-1570	631	6	2003	2003	NUM
admet-1570	631	7	)	)	PUNCT
admet-1570	631	8	163	163	NUM
admet-1570	631	9	-	-	SYM
admet-1570	631	10	168	168	NUM
admet-1570	631	11	.	.	PUNCT
admet-1570	632	1	https://doi.org/10.1016/j.cccn.2003.08.009	https://doi.org/10.1016/j.cccn.2003.08.009	NOUN
admet-1570	632	2	.	.	PUNCT
admet-1570	633	1	[	[	X
admet-1570	633	2	61	61	NUM
admet-1570	633	3	]	]	X
admet-1570	633	4	d.g	d.g	PROPN
admet-1570	633	5	.	.	PROPN
admet-1570	633	6	levitt	levitt	PROPN
admet-1570	633	7	,	,	PUNCT
admet-1570	633	8	m.d	m.d	PROPN
admet-1570	633	9	.	.	PROPN
admet-1570	633	10	levitt	levitt	PROPN
admet-1570	633	11	.	.	PUNCT
admet-1570	634	1	protein	protein	NOUN
admet-1570	634	2	losing	lose	VERB
admet-1570	634	3	enteropathy	enteropathy	ADJ
admet-1570	634	4	:	:	PUNCT
admet-1570	634	5	comprehensive	comprehensive	ADJ
admet-1570	634	6	review	review	NOUN
admet-1570	634	7	of	of	ADP
admet-1570	634	8	the	the	DET
admet-1570	634	9	mechanistic	mechanistic	PROPN
admet-1570	634	10	association	association	NOUN
admet-1570	634	11	with	with	ADP
admet-1570	634	12	clinical	clinical	ADJ
admet-1570	634	13	and	and	CCONJ
admet-1570	634	14	subclinical	subclinical	ADJ
admet-1570	634	15	disease	disease	NOUN
admet-1570	634	16	states	state	NOUN
admet-1570	634	17	.	.	PUNCT
admet-1570	635	1	clin	clin	PROPN
admet-1570	635	2	exp	exp	PROPN
admet-1570	635	3	gastroenterol	gastroenterol	PROPN
admet-1570	635	4	10	10	NUM
admet-1570	635	5	(	(	PUNCT
admet-1570	635	6	2017	2017	NUM
admet-1570	635	7	)	)	PUNCT
admet-1570	635	8	147	147	NUM
admet-1570	635	9	-	-	SYM
admet-1570	635	10	168	168	NUM
admet-1570	635	11	.	.	PUNCT
admet-1570	636	1	https://doi.org/10.2147/ceg.s136803	https://doi.org/10.2147/ceg.s136803	NOUN
admet-1570	636	2	.	.	PUNCT
admet-1570	637	1	[	[	X
admet-1570	637	2	62	62	NUM
admet-1570	637	3	]	]	X
admet-1570	637	4	c.g	c.g	PROPN
admet-1570	637	5	.	.	PROPN
admet-1570	637	6	starr	starr	PROPN
admet-1570	637	7	,	,	PUNCT
admet-1570	637	8	p.m.	p.m.	NOUN
admet-1570	637	9	tessier	tessier	NOUN
admet-1570	637	10	.	.	PUNCT
admet-1570	638	1	selecting	selecting	NOUN
admet-1570	638	2	and	and	CCONJ
admet-1570	638	3	engineering	engineering	NOUN
admet-1570	638	4	monoclonal	monoclonal	NOUN
admet-1570	638	5	antibodies	antibody	NOUN
admet-1570	638	6	with	with	ADP
admet-1570	638	7	drug	drug	NOUN
admet-1570	638	8	-	-	PUNCT
admet-1570	638	9	like	like	ADJ
admet-1570	638	10	specificity	specificity	NOUN
admet-1570	638	11	.	.	PUNCT
admet-1570	639	1	curr	curr	PROPN
admet-1570	639	2	opin	opin	NOUN
admet-1570	639	3	biotechnol	biotechnol	NOUN
admet-1570	639	4	60	60	NUM
admet-1570	639	5	(	(	PUNCT
admet-1570	639	6	2019	2019	NUM
admet-1570	639	7	)	)	PUNCT
admet-1570	639	8	119	119	NUM
admet-1570	639	9	-	-	SYM
admet-1570	639	10	127	127	NUM
admet-1570	639	11	.	.	PUNCT
admet-1570	640	1	https://doi.org/10.1016/j.copbio.2019.01.008	https://doi.org/10.1016/j.copbio.2019.01.008	NOUN
admet-1570	640	2	.	.	PUNCT
admet-1570	641	1	[	[	X
admet-1570	641	2	63	63	NUM
admet-1570	641	3	]	]	X
admet-1570	641	4	d.g	d.g	PROPN
admet-1570	641	5	.	.	PROPN
admet-1570	641	6	levitt	levitt	PROPN
admet-1570	641	7	.	.	PUNCT
admet-1570	642	1	general	general	ADJ
admet-1570	642	2	continuum	continuum	ADJ
admet-1570	642	3	analysis	analysis	NOUN
admet-1570	642	4	of	of	ADP
admet-1570	642	5	transport	transport	NOUN
admet-1570	642	6	through	through	ADP
admet-1570	642	7	pores	pore	NOUN
admet-1570	642	8	.	.	PUNCT
admet-1570	643	1	i.	i.	PROPN
admet-1570	643	2	proof	proof	NOUN
admet-1570	643	3	of	of	ADP
admet-1570	643	4	onsager	onsager	NOUN
admet-1570	643	5	's	's	PART
admet-1570	643	6	reciprocity	reciprocity	NOUN
admet-1570	643	7	postulate	postulate	NOUN
admet-1570	643	8	for	for	ADP
admet-1570	643	9	uniform	uniform	ADJ
admet-1570	643	10	pore	pore	ADJ
admet-1570	643	11	.	.	PUNCT
admet-1570	644	1	biophys	biophy	NOUN
admet-1570	644	2	j	j	PROPN
admet-1570	644	3	15	15	NUM
admet-1570	644	4	(	(	PUNCT
admet-1570	644	5	1975	1975	NUM
admet-1570	644	6	)	)	PUNCT
admet-1570	644	7	533	533	NUM
admet-1570	644	8	-	-	SYM
admet-1570	644	9	551	551	NUM
admet-1570	644	10	.	.	PUNCT
admet-1570	645	1	https://doi.org/10.1016/s00063495(75)85836-x	https://doi.org/10.1016/s00063495(75)85836-x	NOUN
admet-1570	645	2	.	.	PUNCT
admet-1570	646	1	©	©	PROPN
admet-1570	646	2	2023	2023	NUM
admet-1570	646	3	by	by	ADP
admet-1570	646	4	the	the	DET
admet-1570	646	5	authors	author	NOUN
admet-1570	646	6	;	;	PUNCT
admet-1570	646	7	licensee	licensee	PROPN
admet-1570	646	8	iapc	iapc	PROPN
admet-1570	646	9	,	,	PUNCT
admet-1570	646	10	zagreb	zagreb	PROPN
admet-1570	646	11	,	,	PUNCT
admet-1570	646	12	croatia	croatia	PROPN
admet-1570	646	13	.	.	PUNCT
admet-1570	647	1	this	this	DET
admet-1570	647	2	article	article	NOUN
admet-1570	647	3	is	be	AUX
admet-1570	647	4	an	an	DET
admet-1570	647	5	open	open	ADJ
admet-1570	647	6	-	-	PUNCT
admet-1570	647	7	access	access	NOUN
admet-1570	647	8	article	article	NOUN
admet-1570	647	9	distributed	distribute	VERB
admet-1570	647	10	under	under	ADP
admet-1570	647	11	the	the	DET
admet-1570	647	12	terms	term	NOUN
admet-1570	647	13	and	and	CCONJ
admet-1570	647	14	conditions	condition	NOUN
admet-1570	647	15	of	of	ADP
admet-1570	647	16	the	the	DET
admet-1570	647	17	creative	creative	ADJ
admet-1570	647	18	commons	common	NOUN
admet-1570	647	19	attribution	attribution	NOUN
admet-1570	647	20	license	license	NOUN
admet-1570	647	21	(	(	PUNCT
admet-1570	647	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1570	647	23	)	)	PUNCT
admet-1570	647	24	https://doi.org/10.1007/s12291-013-0408-y	https://doi.org/10.1007/s12291-013-0408-y	NOUN
admet-1570	647	25	https://doi.org/10.1093/oxfordjournals.jbchem.a122228	https://doi.org/10.1093/oxfordjournals.jbchem.a122228	PROPN
admet-1570	647	26	https://www.ncbi.nlm.nih.gov/pubmed/5835974	https://www.ncbi.nlm.nih.gov/pubmed/5835974	NUM
admet-1570	647	27	https://doi.org/10.7326/0003-4819-71-5-919	https://doi.org/10.7326/0003-4819-71-5-919	PROPN
admet-1570	647	28	https://doi.org/10.7326/0003-4819-71-5-919	https://doi.org/10.7326/0003-4819-71-5-919	PROPN
admet-1570	647	29	https://www.ncbi.nlm.nih.gov/pubmed/2435254	https://www.ncbi.nlm.nih.gov/pubmed/2435254	NUM
admet-1570	647	30	https://doi.org/10.2147/ceg.s345531	https://doi.org/10.2147/ceg.s345531	NUM
admet-1570	647	31	https://doi.org/10.2147/ceg.s345531	https://doi.org/10.2147/ceg.s345531	NOUN
admet-1570	647	32	https://doi.org/10.1016/j.cccn.2003.08.009	https://doi.org/10.1016/j.cccn.2003.08.009	PROPN
admet-1570	647	33	https://doi.org/10.1016/j.cccn.2003.08.009	https://doi.org/10.1016/j.cccn.2003.08.009	PROPN
admet-1570	647	34	https://doi.org/10.2147/ceg.s136803	https://doi.org/10.2147/ceg.s136803	NOUN
admet-1570	647	35	https://doi.org/10.1016/j.copbio.2019.01.008	https://doi.org/10.1016/j.copbio.2019.01.008	NOUN
admet-1570	647	36	https://doi.org/10.1016/s0006-3495(75)85836-x	https://doi.org/10.1016/s0006-3495(75)85836-x	NOUN
admet-1570	647	37	https://doi.org/10.1016/s0006-3495(75)85836-x	https://doi.org/10.1016/s0006-3495(75)85836-x	PROPN
admet-1570	647	38	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN