id sid tid token lemma pos admet-163 1 1 manuscript manuscript PROPN admet-163 1 2 doi doi PROPN admet-163 1 3 : : PUNCT admet-163 1 4 10.5599 10.5599 NUM admet-163 1 5 / / SYM admet-163 1 6 admet.3.1.163 admet.3.1.163 NUM admet-163 1 7 34 34 NUM admet-163 1 8 admet admet X admet-163 1 9 & & CCONJ admet-163 1 10 dmpk dmpk PROPN admet-163 1 11 3(1 3(1 NUM admet-163 1 12 ) ) PUNCT admet-163 1 13 ( ( PUNCT admet-163 1 14 2015 2015 NUM admet-163 1 15 ) ) PUNCT admet-163 1 16 34 34 NUM admet-163 1 17 - - SYM admet-163 1 18 44 44 NUM admet-163 1 19 ; ; PUNCT admet-163 1 20 doi doi NOUN admet-163 1 21 : : PUNCT admet-163 1 22 10.5599 10.5599 NUM admet-163 1 23 / / SYM admet-163 1 24 admet.3.1.163 admet.3.1.163 ADJ admet-163 1 25 open open ADJ admet-163 1 26 access access NOUN admet-163 1 27 : : PUNCT admet-163 1 28 issn issn PROPN admet-163 1 29 : : PUNCT admet-163 1 30 1848 1848 NUM admet-163 1 31 - - SYM admet-163 1 32 7718 7718 NUM admet-163 1 33 http://www.pub.iapchem.org/ojs/index.php/admet/index http://www.pub.iapchem.org/ojs/index.php/admet/index NOUN admet-163 1 34 original original ADJ admet-163 1 35 scientific scientific ADJ admet-163 1 36 paper paper NOUN admet-163 1 37 characterization characterization NOUN admet-163 1 38 of of ADP admet-163 1 39 slc slc PROPN admet-163 1 40 transporters transporter NOUN admet-163 1 41 in in ADP admet-163 1 42 human human ADJ admet-163 1 43 skin skin NOUN admet-163 1 44 marion marion PROPN admet-163 1 45 alriquet alriquet PROPN admet-163 1 46 , , PUNCT admet-163 1 47 karine karine PROPN admet-163 1 48 sevin sevin PROPN admet-163 1 49 , , PUNCT admet-163 1 50 alexandre alexandre PROPN admet-163 1 51 gaborit gaborit PROPN admet-163 1 52 , , PUNCT admet-163 1 53 pierre pierre PROPN admet-163 1 54 comby comby PROPN admet-163 1 55 , , PUNCT admet-163 1 56 bernard bernard PROPN admet-163 1 57 ruty ruty PROPN admet-163 1 58 and and CCONJ admet-163 1 59 hanan hanan PROPN admet-163 1 60 osman osman PROPN admet-163 1 61 - - PUNCT admet-163 1 62 ponchet ponchet NOUN admet-163 1 63 * * PROPN admet-163 1 64 galderma galderma PROPN admet-163 1 65 r&d r&d NOUN admet-163 1 66 , , PUNCT admet-163 1 67 les les PROPN admet-163 1 68 templiers templier NOUN admet-163 1 69 , , PUNCT admet-163 1 70 2400 2400 NUM admet-163 1 71 route route PROPN admet-163 1 72 des des X admet-163 1 73 colles colles PROPN admet-163 1 74 , , PUNCT admet-163 1 75 bp bp PROPN admet-163 1 76 87 87 NUM admet-163 1 77 , , PUNCT admet-163 1 78 f-06902 f-06902 PROPN admet-163 1 79 sophia sophia PROPN admet-163 1 80 - - PUNCT admet-163 1 81 antipolis antipolis PROPN admet-163 1 82 * * PUNCT admet-163 1 83 corresponding correspond VERB admet-163 1 84 author author NOUN admet-163 1 85 : : PUNCT admet-163 1 86 e e NOUN admet-163 1 87 - - NOUN admet-163 1 88 mail mail NOUN admet-163 1 89 : : PUNCT admet-163 1 90 hanan.osman-ponchet@galderma.com hanan.osman-ponchet@galderma.com PROPN admet-163 1 91 ; ; PUNCT admet-163 1 92 tel tel PROPN admet-163 1 93 . . PUNCT admet-163 1 94 : : PUNCT admet-163 2 1 +33 +33 NUM admet-163 2 2 - - PUNCT admet-163 2 3 492 492 NUM admet-163 2 4 - - PUNCT admet-163 2 5 386 386 NUM admet-163 2 6 - - NUM admet-163 2 7 786 786 NUM admet-163 2 8 ; ; PUNCT admet-163 2 9 fax fax NOUN admet-163 2 10 : : PUNCT admet-163 2 11 +33 +33 NUM admet-163 2 12 - - PUNCT admet-163 2 13 493 493 NUM admet-163 2 14 - - PUNCT admet-163 2 15 957 957 NUM admet-163 2 16 - - PUNCT admet-163 2 17 071 071 NUM admet-163 2 18 received receive VERB admet-163 2 19 : : PUNCT admet-163 2 20 january january PROPN admet-163 2 21 30 30 NUM admet-163 2 22 , , PUNCT admet-163 2 23 2015 2015 NUM admet-163 2 24 ; ; PUNCT admet-163 2 25 revised revise VERB admet-163 2 26 : : PUNCT admet-163 2 27 march march PROPN admet-163 2 28 19 19 NUM admet-163 2 29 , , PUNCT admet-163 2 30 2015 2015 NUM admet-163 2 31 ; ; PUNCT admet-163 2 32 published publish VERB admet-163 2 33 : : PUNCT admet-163 2 34 march march PROPN admet-163 2 35 31 31 NUM admet-163 2 36 , , PUNCT admet-163 2 37 2015 2015 NUM admet-163 2 38 abstract abstract ADV admet-163 2 39 most most ADV admet-163 2 40 identified identify VERB admet-163 2 41 drug drug NOUN admet-163 2 42 transporters transporter NOUN admet-163 2 43 belong belong VERB admet-163 2 44 to to ADP admet-163 2 45 the the DET admet-163 2 46 atp atp NOUN admet-163 2 47 - - PUNCT admet-163 2 48 binding bind VERB admet-163 2 49 cassette cassette NOUN admet-163 2 50 ( ( PUNCT admet-163 2 51 abc abc PROPN admet-163 2 52 ) ) PUNCT admet-163 2 53 and and CCONJ admet-163 2 54 solute solute ADJ admet-163 2 55 carrier carrier NOUN admet-163 2 56 ( ( PUNCT admet-163 2 57 slc slc PROPN admet-163 2 58 ) ) PUNCT admet-163 2 59 families family NOUN admet-163 2 60 . . PUNCT admet-163 3 1 recent recent ADJ admet-163 3 2 research research NOUN admet-163 3 3 indicates indicate VERB admet-163 3 4 that that SCONJ admet-163 3 5 some some PRON admet-163 3 6 of of ADP admet-163 3 7 these these DET admet-163 3 8 transporters transporter NOUN admet-163 3 9 play play VERB admet-163 3 10 an an DET admet-163 3 11 important important ADJ admet-163 3 12 role role NOUN admet-163 3 13 in in ADP admet-163 3 14 the the DET admet-163 3 15 absorption absorption NOUN admet-163 3 16 , , PUNCT admet-163 3 17 distribution distribution NOUN admet-163 3 18 and and CCONJ admet-163 3 19 excretion excretion NOUN admet-163 3 20 of of ADP admet-163 3 21 drugs drug NOUN admet-163 3 22 , , PUNCT admet-163 3 23 and and CCONJ admet-163 3 24 are be AUX admet-163 3 25 involved involve VERB admet-163 3 26 in in ADP admet-163 3 27 clinically clinically ADV admet-163 3 28 relevant relevant ADJ admet-163 3 29 drug drug NOUN admet-163 3 30 - - PUNCT admet-163 3 31 drug drug NOUN admet-163 3 32 interactions interaction NOUN admet-163 3 33 for for ADP admet-163 3 34 systemic systemic ADJ admet-163 3 35 drugs drug NOUN admet-163 3 36 . . PUNCT admet-163 4 1 however however ADV admet-163 4 2 , , PUNCT admet-163 4 3 very very ADV admet-163 4 4 little little ADJ admet-163 4 5 is be AUX admet-163 4 6 known know VERB admet-163 4 7 about about ADP admet-163 4 8 the the DET admet-163 4 9 role role NOUN admet-163 4 10 of of ADP admet-163 4 11 drug drug NOUN admet-163 4 12 transporters transporter NOUN admet-163 4 13 in in ADP admet-163 4 14 human human ADJ admet-163 4 15 skin skin NOUN admet-163 4 16 in in ADP admet-163 4 17 the the DET admet-163 4 18 disposition disposition NOUN admet-163 4 19 of of ADP admet-163 4 20 topically topically ADV admet-163 4 21 applied apply VERB admet-163 4 22 drugs drug NOUN admet-163 4 23 and and CCONJ admet-163 4 24 their their PRON admet-163 4 25 involvement involvement NOUN admet-163 4 26 in in ADP admet-163 4 27 drug drug NOUN admet-163 4 28 - - PUNCT admet-163 4 29 drug drug NOUN admet-163 4 30 interactions interaction NOUN admet-163 4 31 . . PUNCT admet-163 5 1 the the DET admet-163 5 2 aim aim NOUN admet-163 5 3 of of ADP admet-163 5 4 this this DET admet-163 5 5 work work NOUN admet-163 5 6 was be AUX admet-163 5 7 to to PART admet-163 5 8 compare compare VERB admet-163 5 9 the the DET admet-163 5 10 expression expression NOUN admet-163 5 11 in in ADP admet-163 5 12 human human ADJ admet-163 5 13 skin skin NOUN admet-163 5 14 ( ( PUNCT admet-163 5 15 vs vs ADP admet-163 5 16 human human ADJ admet-163 5 17 hepatocytes hepatocyte NOUN admet-163 5 18 and and CCONJ admet-163 5 19 kidney kidney NOUN admet-163 5 20 ) ) PUNCT admet-163 5 21 of of ADP admet-163 5 22 slc slc PROPN admet-163 5 23 transporters transporter NOUN admet-163 5 24 included include VERB admet-163 5 25 in in ADP admet-163 5 26 the the DET admet-163 5 27 ema ema PROPN admet-163 5 28 guidance guidance NOUN admet-163 5 29 as as ADP admet-163 5 30 the the DET admet-163 5 31 most most ADV admet-163 5 32 likely likely ADJ admet-163 5 33 clinical clinical ADJ admet-163 5 34 sources source NOUN admet-163 5 35 of of ADP admet-163 5 36 drug drug NOUN admet-163 5 37 interactions interaction NOUN admet-163 5 38 . . PUNCT admet-163 6 1 the the DET admet-163 6 2 expression expression NOUN admet-163 6 3 of of ADP admet-163 6 4 slc slc PROPN admet-163 6 5 transporters transporter NOUN admet-163 6 6 in in ADP admet-163 6 7 human human ADJ admet-163 6 8 tissues tissue NOUN admet-163 6 9 was be AUX admet-163 6 10 analyzed analyze VERB admet-163 6 11 by by ADP admet-163 6 12 quantitative quantitative ADJ admet-163 6 13 rt rt PROPN admet-163 6 14 - - PUNCT admet-163 6 15 pcr pcr NOUN admet-163 6 16 . . PUNCT admet-163 7 1 modulation modulation NOUN admet-163 7 2 of of ADP admet-163 7 3 slc47a1 slc47a1 NOUN admet-163 7 4 and and CCONJ admet-163 7 5 slc47a2 slc47a2 PROPN admet-163 7 6 ( ( PUNCT admet-163 7 7 mate1 mate1 NOUN admet-163 7 8 and and CCONJ admet-163 7 9 mate2 mate2 NOUN admet-163 7 10 ) ) PUNCT admet-163 7 11 expression expression NOUN admet-163 7 12 was be AUX admet-163 7 13 analyzed analyze VERB admet-163 7 14 after after ADP admet-163 7 15 treatment treatment NOUN admet-163 7 16 of of ADP admet-163 7 17 human human ADJ admet-163 7 18 skin skin NOUN admet-163 7 19 in in ADP admet-163 7 20 organ organ NOUN admet-163 7 21 - - PUNCT admet-163 7 22 culture culture NOUN admet-163 7 23 with with ADP admet-163 7 24 rifampicin rifampicin VERB admet-163 7 25 and and CCONJ admet-163 7 26 uv uv NOUN admet-163 7 27 irradiation irradiation NOUN admet-163 7 28 . . PUNCT admet-163 8 1 the the DET admet-163 8 2 expression expression NOUN admet-163 8 3 of of ADP admet-163 8 4 slco2b1 slco2b1 PRON admet-163 8 5 ( ( PUNCT admet-163 8 6 oatpb oatpb PROPN admet-163 8 7 ) ) PUNCT admet-163 8 8 , , PUNCT admet-163 8 9 slco3a1 slco3a1 PUNCT admet-163 8 10 ( ( PUNCT admet-163 8 11 oatpd oatpd ADJ admet-163 8 12 ) ) PUNCT admet-163 8 13 , , PUNCT admet-163 8 14 slco4a1 slco4a1 CCONJ admet-163 8 15 ( ( PUNCT admet-163 8 16 oatpe oatpe NOUN admet-163 8 17 ) ) PUNCT admet-163 8 18 , , PUNCT admet-163 8 19 slc47a1 slc47a1 NOUN admet-163 8 20 and and CCONJ admet-163 8 21 slc47a2 slc47a2 PROPN admet-163 8 22 ( ( PUNCT admet-163 8 23 mate1 mate1 NOUN admet-163 8 24 and and CCONJ admet-163 8 25 mate2 mate2 NOUN admet-163 8 26 ) ) PUNCT admet-163 8 27 was be AUX admet-163 8 28 detected detect VERB admet-163 8 29 in in ADP admet-163 8 30 human human ADJ admet-163 8 31 skin skin NOUN admet-163 8 32 , , PUNCT admet-163 8 33 oatpe oatpe NOUN admet-163 8 34 and and CCONJ admet-163 8 35 mate1 mate1 NOUN admet-163 8 36 being be AUX admet-163 8 37 the the DET admet-163 8 38 most most ADV admet-163 8 39 expressed express VERB admet-163 8 40 . . PUNCT admet-163 9 1 oatpe oatpe NOUN admet-163 9 2 is be AUX admet-163 9 3 about about ADV admet-163 9 4 70 70 NUM admet-163 9 5 times time NOUN admet-163 9 6 more more ADV admet-163 9 7 expressed express VERB admet-163 9 8 in in ADP admet-163 9 9 human human ADJ admet-163 9 10 skin skin NOUN admet-163 9 11 than than ADP admet-163 9 12 in in ADP admet-163 9 13 human human ADJ admet-163 9 14 hepatocytes hepatocyte NOUN admet-163 9 15 . . PUNCT admet-163 10 1 moreover moreover ADV admet-163 10 2 , , PUNCT admet-163 10 3 the the DET admet-163 10 4 expression expression NOUN admet-163 10 5 of of ADP admet-163 10 6 slc47a1 slc47a1 NOUN admet-163 10 7 and and CCONJ admet-163 10 8 slc47a2 slc47a2 PROPN admet-163 10 9 was be AUX admet-163 10 10 down down ADV admet-163 10 11 - - PUNCT admet-163 10 12 regulated regulate VERB admet-163 10 13 after after ADP admet-163 10 14 treatment treatment NOUN admet-163 10 15 with with ADP admet-163 10 16 rifampicin rifampicin VERB admet-163 10 17 or or CCONJ admet-163 10 18 after after ADP admet-163 10 19 exposure exposure NOUN admet-163 10 20 to to ADP admet-163 10 21 uv uv NOUN admet-163 10 22 light light NOUN admet-163 10 23 . . PUNCT admet-163 11 1 the the DET admet-163 11 2 present present ADJ admet-163 11 3 findings finding NOUN admet-163 11 4 demonstrate demonstrate VERB admet-163 11 5 that that SCONJ admet-163 11 6 slco4a1 slco4a1 NOUN admet-163 11 7 ( ( PUNCT admet-163 11 8 oatpe oatpe NOUN admet-163 11 9 ) ) PUNCT admet-163 11 10 and and CCONJ admet-163 11 11 slc47a1 slc47a1 NOUN admet-163 11 12 ( ( PUNCT admet-163 11 13 mate1 mate1 NOUN admet-163 11 14 ) ) PUNCT admet-163 11 15 are be AUX admet-163 11 16 highly highly ADV admet-163 11 17 expressed express VERB admet-163 11 18 in in ADP admet-163 11 19 human human ADJ admet-163 11 20 skin skin NOUN admet-163 11 21 and and CCONJ admet-163 11 22 suggest suggest VERB admet-163 11 23 the the DET admet-163 11 24 involvement involvement NOUN admet-163 11 25 of of ADP admet-163 11 26 slc slc PROPN admet-163 11 27 transporters transporter NOUN admet-163 11 28 in in ADP admet-163 11 29 the the DET admet-163 11 30 disposition disposition NOUN admet-163 11 31 of of ADP admet-163 11 32 topically topically ADV admet-163 11 33 applied apply VERB admet-163 11 34 drugs drug NOUN admet-163 11 35 . . PUNCT admet-163 12 1 keywords keyword NOUN admet-163 12 2 solute solute NOUN admet-163 12 3 - - PUNCT admet-163 12 4 carrier carrier NOUN admet-163 12 5 transporter transporter NOUN admet-163 12 6 ; ; PUNCT admet-163 12 7 mate1 mate1 NOUN admet-163 12 8 ; ; PUNCT admet-163 12 9 uv uv NOUN admet-163 12 10 light light NOUN admet-163 12 11 ; ; PUNCT admet-163 12 12 skin skin NOUN admet-163 12 13 absorption absorption NOUN admet-163 12 14 introduction introduction NOUN admet-163 12 15 the the DET admet-163 12 16 human human ADJ admet-163 12 17 skin skin NOUN admet-163 12 18 , , PUNCT admet-163 12 19 one one NUM admet-163 12 20 of of ADP admet-163 12 21 the the DET admet-163 12 22 largest large ADJ admet-163 12 23 organ organ NOUN admet-163 12 24 in in ADP admet-163 12 25 the the DET admet-163 12 26 organism organism NOUN admet-163 12 27 with with ADP admet-163 12 28 about about ADV admet-163 12 29 6 6 NUM admet-163 12 30 % % NOUN admet-163 12 31 of of ADP admet-163 12 32 total total ADJ admet-163 12 33 body body NOUN admet-163 12 34 weight weight NOUN admet-163 12 35 ( ( PUNCT admet-163 12 36 5 5 NUM admet-163 12 37 - - SYM admet-163 12 38 6 6 NUM admet-163 12 39 kg kg NOUN admet-163 12 40 , , PUNCT admet-163 12 41 2 2 NUM admet-163 12 42 m2 m2 PROPN admet-163 12 43 in in ADP admet-163 12 44 area area NOUN admet-163 12 45 ) ) PUNCT admet-163 12 46 , , PUNCT admet-163 12 47 acts act VERB admet-163 12 48 as as ADP admet-163 12 49 a a DET admet-163 12 50 physical physical ADJ admet-163 12 51 and and CCONJ admet-163 12 52 biochemical biochemical ADJ admet-163 12 53 barrier barrier NOUN admet-163 12 54 to to PART admet-163 12 55 protect protect VERB admet-163 12 56 the the DET admet-163 12 57 body body NOUN admet-163 12 58 from from ADP admet-163 12 59 environmental environmental ADJ admet-163 12 60 factors factor NOUN admet-163 12 61 and and CCONJ admet-163 12 62 also also ADV admet-163 12 63 plays play VERB admet-163 12 64 a a DET admet-163 12 65 pivotal pivotal ADJ admet-163 12 66 role role NOUN admet-163 12 67 in in ADP admet-163 12 68 homeostasis homeostasis NOUN admet-163 12 69 by by ADP admet-163 12 70 preventing prevent VERB admet-163 12 71 the the DET admet-163 12 72 uncontrolled uncontrolled ADJ admet-163 12 73 loss loss NOUN admet-163 12 74 of of ADP admet-163 12 75 water water NOUN admet-163 12 76 [ [ X admet-163 12 77 1 1 NUM admet-163 12 78 ] ] PUNCT admet-163 12 79 . . PUNCT admet-163 13 1 although although SCONJ admet-163 13 2 constitutive constitutive ADJ admet-163 13 3 expression expression NOUN admet-163 13 4 of of ADP admet-163 13 5 xenobiotic xenobiotic ADJ admet-163 13 6 - - PUNCT admet-163 13 7 metabolizing metabolize VERB admet-163 13 8 enzymes enzyme NOUN admet-163 13 9 has have AUX admet-163 13 10 been be AUX admet-163 13 11 detected detect VERB admet-163 13 12 in in ADP admet-163 13 13 normal normal ADJ admet-163 13 14 keratinocytes keratinocyte NOUN admet-163 13 15 [ [ X admet-163 13 16 2,3 2,3 NUM admet-163 13 17 ] ] PUNCT admet-163 13 18 the the DET admet-163 13 19 levels level NOUN admet-163 13 20 of of ADP admet-163 13 21 drug drug NOUN admet-163 13 22 - - PUNCT admet-163 13 23 metabolizing metabolize VERB admet-163 13 24 enzymes enzyme NOUN admet-163 13 25 are be AUX admet-163 13 26 generally generally ADV admet-163 13 27 much much ADV admet-163 13 28 lower low ADJ admet-163 13 29 in in ADP admet-163 13 30 the the DET admet-163 13 31 skin skin NOUN admet-163 13 32 than than ADP admet-163 13 33 those those PRON admet-163 13 34 in in ADP admet-163 13 35 the the DET admet-163 13 36 liver liver NOUN admet-163 13 37 and and CCONJ admet-163 13 38 intestine intestine NOUN admet-163 13 39 [ [ PUNCT admet-163 13 40 4 4 NUM admet-163 13 41 - - SYM admet-163 13 42 7 7 NUM admet-163 13 43 ] ] PUNCT admet-163 13 44 . . PUNCT admet-163 14 1 thus thus ADV admet-163 14 2 , , PUNCT admet-163 14 3 skin skin NOUN admet-163 14 4 permeability permeability NOUN admet-163 14 5 rather rather ADV admet-163 14 6 than than ADP admet-163 14 7 drug drug NOUN admet-163 14 8 metabolism metabolism NOUN admet-163 14 9 appears appear VERB admet-163 14 10 to to PART admet-163 14 11 be be AUX admet-163 14 12 the the DET admet-163 14 13 major major ADJ admet-163 14 14 barrier barrier NOUN admet-163 14 15 to to ADP admet-163 14 16 topical topical ADJ admet-163 14 17 bioavailability bioavailability NOUN admet-163 14 18 [ [ X admet-163 14 19 8,9 8,9 NUM admet-163 14 20 ] ] PUNCT admet-163 14 21 . . PUNCT admet-163 15 1 http://www.pub.iapchem.org/ojs/index.php/admet/index http://www.pub.iapchem.org/ojs/index.php/admet/index PROPN admet-163 15 2 mailto:hanan.osman-ponchet@galderma.com mailto:hanan.osman-ponchet@galderma.com PROPN admet-163 15 3 admet admet PROPN admet-163 15 4 & & CCONJ admet-163 15 5 dmpk dmpk PROPN admet-163 15 6 3(1 3(1 NUM admet-163 15 7 ) ) PUNCT admet-163 15 8 ( ( PUNCT admet-163 15 9 2015 2015 NUM admet-163 15 10 ) ) PUNCT admet-163 15 11 34 34 NUM admet-163 15 12 - - SYM admet-163 15 13 44 44 NUM admet-163 15 14 expression expression NOUN admet-163 15 15 of of ADP admet-163 15 16 slc slc PROPN admet-163 15 17 transporters transporter NOUN admet-163 15 18 in in ADP admet-163 15 19 human human ADJ admet-163 15 20 skin skin NOUN admet-163 15 21 doi doi NOUN admet-163 15 22 : : PUNCT admet-163 15 23 10.5599 10.5599 NUM admet-163 15 24 / / SYM admet-163 15 25 admet.3.1.163 admet.3.1.163 NUM admet-163 15 26 35 35 NUM admet-163 15 27 most most ADV admet-163 15 28 identified identify VERB admet-163 15 29 drug drug NOUN admet-163 15 30 transporters transporter NOUN admet-163 15 31 belong belong VERB admet-163 15 32 to to ADP admet-163 15 33 the the DET admet-163 15 34 atp atp NOUN admet-163 15 35 - - PUNCT admet-163 15 36 binding bind VERB admet-163 15 37 cassette cassette NOUN admet-163 15 38 ( ( PUNCT admet-163 15 39 abc abc PROPN admet-163 15 40 ) ) PUNCT admet-163 15 41 and and CCONJ admet-163 15 42 solute solute ADJ admet-163 15 43 carrier carrier NOUN admet-163 15 44 ( ( PUNCT admet-163 15 45 slc slc PROPN admet-163 15 46 ) ) PUNCT admet-163 15 47 families family NOUN admet-163 15 48 . . PUNCT admet-163 16 1 xenobiotic xenobiotic ADJ admet-163 16 2 transporters transporter NOUN admet-163 16 3 ( ( PUNCT admet-163 16 4 abcs abc NOUN admet-163 16 5 and and CCONJ admet-163 16 6 slcs slcs NOUN admet-163 16 7 ) ) PUNCT admet-163 16 8 have have VERB admet-163 16 9 broad broad ADJ admet-163 16 10 specificity specificity NOUN admet-163 16 11 and and CCONJ admet-163 16 12 are be AUX admet-163 16 13 involved involve VERB admet-163 16 14 in in ADP admet-163 16 15 both both CCONJ admet-163 16 16 uptake uptake ADJ admet-163 16 17 ( ( PUNCT admet-163 16 18 influx influx NOUN admet-163 16 19 ) ) PUNCT admet-163 16 20 and and CCONJ admet-163 16 21 secretion secretion NOUN admet-163 16 22 ( ( PUNCT admet-163 16 23 efflux efflux PROPN admet-163 16 24 ) ) PUNCT admet-163 16 25 of of ADP admet-163 16 26 their their PRON admet-163 16 27 substrates substrate NOUN admet-163 16 28 , , PUNCT admet-163 16 29 thereby thereby ADV admet-163 16 30 affecting affect VERB admet-163 16 31 their their PRON admet-163 16 32 cellular cellular ADJ admet-163 16 33 disposition disposition NOUN admet-163 16 34 . . PUNCT admet-163 17 1 constitutive constitutive ADJ admet-163 17 2 expression expression NOUN admet-163 17 3 of of ADP admet-163 17 4 multidrug multidrug NOUN admet-163 17 5 - - PUNCT admet-163 17 6 resistance resistance NOUN admet-163 17 7 associated associate VERB admet-163 17 8 proteins protein NOUN admet-163 17 9 ( ( PUNCT admet-163 17 10 mrp mrp NOUN admet-163 17 11 , , PUNCT admet-163 17 12 abcc abcc NOUN admet-163 17 13 ) ) PUNCT admet-163 17 14 or or CCONJ admet-163 17 15 solute solute NOUN admet-163 17 16 carrier carrier NOUN admet-163 17 17 organic organic ADJ admet-163 17 18 anion anion NOUN admet-163 17 19 transporting transport VERB admet-163 17 20 polypeptides polypeptide NOUN admet-163 17 21 ( ( PUNCT admet-163 17 22 oatps oatps NOUN admet-163 17 23 ) ) PUNCT admet-163 17 24 has have AUX admet-163 17 25 been be AUX admet-163 17 26 detected detect VERB admet-163 17 27 in in ADP admet-163 17 28 human human ADJ admet-163 17 29 keratinocytes keratinocyte NOUN admet-163 17 30 [ [ X admet-163 17 31 2,3,10,11 2,3,10,11 NOUN admet-163 17 32 ] ] PUNCT admet-163 17 33 . . PUNCT admet-163 18 1 the the DET admet-163 18 2 expression expression NOUN admet-163 18 3 of of ADP admet-163 18 4 abcb1 abcb1 NOUN admet-163 18 5 ( ( PUNCT admet-163 18 6 multidrug multidrug VERB admet-163 18 7 resistance resistance NOUN admet-163 18 8 protein protein NOUN admet-163 18 9 1 1 NUM admet-163 18 10 , , PUNCT admet-163 18 11 p p NOUN admet-163 18 12 - - PUNCT admet-163 18 13 glycoprotein glycoprotein NOUN admet-163 18 14 or or CCONJ admet-163 18 15 p p NOUN admet-163 18 16 - - PUNCT admet-163 18 17 gp gp NOUN admet-163 18 18 ) ) PUNCT admet-163 18 19 has have AUX admet-163 18 20 only only ADV admet-163 18 21 been be AUX admet-163 18 22 found find VERB admet-163 18 23 after after ADP admet-163 18 24 keratinocyte keratinocyte NOUN admet-163 18 25 treatment treatment NOUN admet-163 18 26 with with ADP admet-163 18 27 dexamethasone dexamethasone NOUN admet-163 18 28 [ [ X admet-163 18 29 2 2 NUM admet-163 18 30 ] ] PUNCT admet-163 18 31 . . PUNCT admet-163 19 1 current current ADJ admet-163 19 2 knowledge knowledge NOUN admet-163 19 3 about about ADP admet-163 19 4 the the DET admet-163 19 5 function function NOUN admet-163 19 6 of of ADP admet-163 19 7 xenobiotic xenobiotic ADJ admet-163 19 8 transporters transporter NOUN admet-163 19 9 in in ADP admet-163 19 10 the the DET admet-163 19 11 skin skin NOUN admet-163 19 12 is be AUX admet-163 19 13 limited limited ADJ admet-163 19 14 . . PUNCT admet-163 20 1 in in ADP admet-163 20 2 addition addition NOUN admet-163 20 3 to to ADP admet-163 20 4 their their PRON admet-163 20 5 role role NOUN admet-163 20 6 as as ADP admet-163 20 7 a a DET admet-163 20 8 contributor contributor NOUN admet-163 20 9 to to PART admet-163 20 10 multidrug multidrug VERB admet-163 20 11 resistance resistance NOUN admet-163 20 12 , , PUNCT admet-163 20 13 it it PRON admet-163 20 14 has have AUX admet-163 20 15 been be AUX admet-163 20 16 demonstrated demonstrate VERB admet-163 20 17 that that SCONJ admet-163 20 18 p p NOUN admet-163 20 19 - - PUNCT admet-163 20 20 gp gp NOUN admet-163 20 21 as as ADV admet-163 20 22 well well ADV admet-163 20 23 as as ADP admet-163 20 24 mrp1 mrp1 NOUN admet-163 20 25 help help AUX admet-163 20 26 maintain maintain VERB admet-163 20 27 a a DET admet-163 20 28 healthy healthy ADJ admet-163 20 29 immune immune ADJ admet-163 20 30 response response NOUN admet-163 20 31 in in ADP admet-163 20 32 the the DET admet-163 20 33 skin skin NOUN admet-163 20 34 as as SCONJ admet-163 20 35 they they PRON admet-163 20 36 play play VERB admet-163 20 37 an an DET admet-163 20 38 important important ADJ admet-163 20 39 role role NOUN admet-163 20 40 in in ADP admet-163 20 41 the the DET admet-163 20 42 migration migration NOUN admet-163 20 43 of of ADP admet-163 20 44 langerhans langerhans ADJ admet-163 20 45 cells cell NOUN admet-163 20 46 out out ADP admet-163 20 47 of of ADP admet-163 20 48 the the DET admet-163 20 49 skin skin NOUN admet-163 20 50 by by ADP admet-163 20 51 way way NOUN admet-163 20 52 of of ADP admet-163 20 53 the the DET admet-163 20 54 lymphatic lymphatic ADJ admet-163 20 55 vessels vessel NOUN admet-163 20 56 [ [ X admet-163 20 57 12 12 NUM admet-163 20 58 ] ] PUNCT admet-163 20 59 . . PUNCT admet-163 21 1 in in ADP admet-163 21 2 addition addition NOUN admet-163 21 3 , , PUNCT admet-163 21 4 these these DET admet-163 21 5 transporters transporter NOUN admet-163 21 6 also also ADV admet-163 21 7 play play VERB admet-163 21 8 a a DET admet-163 21 9 role role NOUN admet-163 21 10 in in ADP admet-163 21 11 the the DET admet-163 21 12 active active ADJ admet-163 21 13 efflux efflux NOUN admet-163 21 14 of of ADP admet-163 21 15 contact contact NOUN admet-163 21 16 allergens allergen NOUN admet-163 21 17 and and CCONJ admet-163 21 18 endogenous endogenous ADJ admet-163 21 19 compounds compound NOUN admet-163 21 20 such such ADJ admet-163 21 21 as as ADP admet-163 21 22 steroid steroid NOUN admet-163 21 23 hormones hormone NOUN admet-163 21 24 from from ADP admet-163 21 25 normal normal ADJ admet-163 21 26 human human ADJ admet-163 21 27 epidermal epidermal ADJ admet-163 21 28 keratinocytes keratinocyte NOUN admet-163 21 29 ( ( PUNCT admet-163 21 30 nhek nhek NOUN admet-163 21 31 ) ) PUNCT admet-163 22 1 [ [ X admet-163 22 2 13 13 NUM admet-163 22 3 ] ] PUNCT admet-163 22 4 . . PUNCT admet-163 23 1 further further PROPN admet-163 23 2 studies study NOUN admet-163 23 3 demonstrated demonstrate VERB admet-163 23 4 p p NOUN admet-163 23 5 - - PUNCT admet-163 23 6 gp gp NOUN admet-163 23 7 involvement involvement NOUN admet-163 23 8 in in ADP admet-163 23 9 migration migration NOUN admet-163 23 10 and and CCONJ admet-163 23 11 invasion invasion NOUN admet-163 23 12 of of ADP admet-163 23 13 resistant resistant ADJ admet-163 23 14 melanoma melanoma NOUN admet-163 23 15 cells cell NOUN admet-163 23 16 [ [ X admet-163 23 17 14 14 NUM admet-163 23 18 ] ] PUNCT admet-163 23 19 , , PUNCT admet-163 23 20 whereas whereas SCONJ admet-163 23 21 very very ADV admet-163 23 22 low low ADJ admet-163 23 23 or or CCONJ admet-163 23 24 no no PRON admet-163 23 25 expression expression NOUN admet-163 23 26 of of ADP admet-163 23 27 p p NOUN admet-163 23 28 - - PUNCT admet-163 23 29 gp gp NOUN admet-163 23 30 was be AUX admet-163 23 31 detected detect VERB admet-163 23 32 in in ADP admet-163 23 33 primary primary ADJ admet-163 23 34 human human ADJ admet-163 23 35 melanocytes melanocyte NOUN admet-163 23 36 [ [ X admet-163 23 37 15 15 NUM admet-163 23 38 ] ] PUNCT admet-163 23 39 . . PUNCT admet-163 24 1 recently recently ADV admet-163 24 2 the the DET admet-163 24 3 expression expression NOUN admet-163 24 4 pattern pattern NOUN admet-163 24 5 of of ADP admet-163 24 6 human human PROPN admet-163 24 7 atp atp NOUN admet-163 24 8 - - PUNCT admet-163 24 9 binding bind VERB admet-163 24 10 cassette cassette NOUN admet-163 24 11 transporters transporter NOUN admet-163 24 12 was be AUX admet-163 24 13 reported report VERB admet-163 24 14 in in ADP admet-163 24 15 human human ADJ admet-163 24 16 skin skin NOUN admet-163 24 17 [ [ X admet-163 24 18 16 16 NUM admet-163 24 19 ] ] PUNCT admet-163 24 20 . . PUNCT admet-163 25 1 in in ADP admet-163 25 2 addition addition NOUN admet-163 25 3 the the DET admet-163 25 4 characterization characterization NOUN admet-163 25 5 of of ADP admet-163 25 6 abc abc PROPN admet-163 25 7 transporters transporter NOUN admet-163 25 8 in in ADP admet-163 25 9 human human ADJ admet-163 25 10 skin skin NOUN admet-163 25 11 was be AUX admet-163 25 12 reported report VERB admet-163 25 13 recently recently ADV admet-163 25 14 by by ADP admet-163 25 15 our our PRON admet-163 25 16 group group NOUN admet-163 25 17 [ [ X admet-163 25 18 17 17 NUM admet-163 25 19 ] ] PUNCT admet-163 25 20 . . PUNCT admet-163 26 1 the the DET admet-163 26 2 present present ADJ admet-163 26 3 study study NOUN admet-163 26 4 was be AUX admet-163 26 5 not not PART admet-163 26 6 intended intend VERB admet-163 26 7 to to PART admet-163 26 8 be be AUX admet-163 26 9 an an DET admet-163 26 10 exhaustive exhaustive ADJ admet-163 26 11 search search NOUN admet-163 26 12 for for ADP admet-163 26 13 slc slc PROPN admet-163 26 14 transporter transporter NOUN admet-163 26 15 expression expression NOUN admet-163 26 16 in in ADP admet-163 26 17 human human ADJ admet-163 26 18 skin skin NOUN admet-163 26 19 . . PUNCT admet-163 27 1 this this PRON admet-163 27 2 has have AUX admet-163 27 3 been be AUX admet-163 27 4 reported report VERB admet-163 27 5 in in ADP admet-163 27 6 human human ADJ admet-163 27 7 keratinocytes keratinocyte NOUN admet-163 27 8 by by ADP admet-163 27 9 schiffer schiffer PROPN admet-163 27 10 et et PROPN admet-163 27 11 al al PROPN admet-163 27 12 . . PUNCT admet-163 28 1 [ [ X admet-163 28 2 3 3 X admet-163 28 3 ] ] PUNCT admet-163 28 4 and and CCONJ admet-163 28 5 in in ADP admet-163 28 6 human human ADJ admet-163 28 7 skin skin NOUN admet-163 28 8 by by ADP admet-163 28 9 li li PROPN admet-163 28 10 et et PROPN admet-163 28 11 al al PROPN admet-163 28 12 . . PUNCT admet-163 29 1 [ [ X admet-163 29 2 18 18 NUM admet-163 29 3 ] ] PUNCT admet-163 29 4 and and CCONJ admet-163 29 5 more more ADV admet-163 29 6 recently recently ADV admet-163 29 7 by by ADP admet-163 29 8 fujiwara fujiwara PROPN admet-163 29 9 et et PROPN admet-163 29 10 al al PROPN admet-163 29 11 . . PUNCT admet-163 30 1 [ [ X admet-163 30 2 19 19 NUM admet-163 30 3 ] ] PUNCT admet-163 30 4 . . PUNCT admet-163 31 1 it it PRON admet-163 31 2 should should AUX admet-163 31 3 be be AUX admet-163 31 4 noted note VERB admet-163 31 5 that that SCONJ admet-163 31 6 mate1 mate1 NOUN admet-163 31 7 and and CCONJ admet-163 31 8 mate2 mate2 NOUN admet-163 31 9 transporters transporter NOUN admet-163 31 10 were be AUX admet-163 31 11 not not PART admet-163 31 12 included include VERB admet-163 31 13 in in ADP admet-163 31 14 those those DET admet-163 31 15 studies study NOUN admet-163 31 16 . . PUNCT admet-163 32 1 the the DET admet-163 32 2 aim aim NOUN admet-163 32 3 of of ADP admet-163 32 4 our our PRON admet-163 32 5 study study NOUN admet-163 32 6 was be AUX admet-163 32 7 to to PART admet-163 32 8 compare compare VERB admet-163 32 9 the the DET admet-163 32 10 expression expression NOUN admet-163 32 11 in in ADP admet-163 32 12 human human ADJ admet-163 32 13 skin skin NOUN admet-163 32 14 ( ( PUNCT admet-163 32 15 vs vs ADP admet-163 32 16 human human ADJ admet-163 32 17 hepatocytes hepatocyte NOUN admet-163 32 18 and and CCONJ admet-163 32 19 kidney kidney NOUN admet-163 32 20 ) ) PUNCT admet-163 32 21 of of ADP admet-163 32 22 slc slc PROPN admet-163 32 23 transporters transporter NOUN admet-163 32 24 included include VERB admet-163 32 25 in in ADP admet-163 32 26 the the DET admet-163 32 27 ema ema PROPN admet-163 32 28 guidance guidance NOUN admet-163 32 29 [ [ X admet-163 32 30 20 20 NUM admet-163 32 31 ] ] PUNCT admet-163 32 32 as as ADP admet-163 32 33 the the DET admet-163 32 34 most most ADV admet-163 32 35 likely likely ADJ admet-163 32 36 clinical clinical ADJ admet-163 32 37 sources source NOUN admet-163 32 38 of of ADP admet-163 32 39 drug drug NOUN admet-163 32 40 interactions interaction NOUN admet-163 32 41 ( ( PUNCT admet-163 32 42 slco1b1 slco1b1 NUM admet-163 32 43 , , PUNCT admet-163 32 44 slco1b3 slco1b3 NOUN admet-163 32 45 , , PUNCT admet-163 32 46 slc22a1 slc22a1 PROPN admet-163 32 47 , , PUNCT admet-163 32 48 slc22a2 slc22a2 NOUN admet-163 32 49 , , PUNCT admet-163 32 50 slc22a6 slc22a6 PROPN admet-163 32 51 , , PUNCT admet-163 32 52 slc22a8 slc22a8 NOUN admet-163 32 53 , , PUNCT admet-163 32 54 slc47a1 slc47a1 NOUN admet-163 32 55 and and CCONJ admet-163 32 56 slc47a2 slc47a2 NUM admet-163 32 57 ) ) PUNCT admet-163 32 58 . . PUNCT admet-163 33 1 this this DET admet-163 33 2 list list NOUN admet-163 33 3 of of ADP admet-163 33 4 slc slc PROPN admet-163 33 5 transporters transporter NOUN admet-163 33 6 is be AUX admet-163 33 7 essentially essentially ADV admet-163 33 8 the the DET admet-163 33 9 same same ADJ admet-163 33 10 as as ADP admet-163 33 11 the the DET admet-163 33 12 one one NOUN admet-163 33 13 reported report VERB admet-163 33 14 in in ADP admet-163 33 15 the the DET admet-163 33 16 recent recent ADJ admet-163 33 17 review review NOUN admet-163 33 18 by by ADP admet-163 33 19 maeda maeda PROPN admet-163 33 20 and and CCONJ admet-163 33 21 sugiyama sugiyama NOUN admet-163 33 22 [ [ X admet-163 33 23 21 21 NUM admet-163 33 24 ] ] X admet-163 33 25 : : PUNCT admet-163 33 26 list list NOUN admet-163 33 27 which which PRON admet-163 33 28 is be AUX admet-163 33 29 based base VERB admet-163 33 30 on on ADP admet-163 33 31 the the DET admet-163 33 32 fda fda PROPN admet-163 33 33 guidance guidance NOUN admet-163 33 34 [ [ X admet-163 33 35 22 22 NUM admet-163 33 36 ] ] PUNCT admet-163 33 37 to to PART admet-163 33 38 which which PRON admet-163 33 39 these these DET admet-163 33 40 authors author NOUN admet-163 33 41 added add VERB admet-163 33 42 mate1 mate1 NOUN admet-163 33 43 and and CCONJ admet-163 33 44 mate2 mate2 NOUN admet-163 33 45 transporters transporter NOUN admet-163 33 46 . . PUNCT admet-163 34 1 three three NUM admet-163 34 2 others other NOUN admet-163 34 3 transporters transporter NOUN admet-163 34 4 slco2b1 slco2b1 NUM admet-163 34 5 ( ( PUNCT admet-163 34 6 oatpb oatpb PROPN admet-163 34 7 ) ) PUNCT admet-163 34 8 , , PUNCT admet-163 34 9 slco3a1 slco3a1 PUNCT admet-163 34 10 ( ( PUNCT admet-163 34 11 oatpd oatpd ADJ admet-163 34 12 ) ) PUNCT admet-163 34 13 and and CCONJ admet-163 34 14 slco4a1 slco4a1 INTJ admet-163 34 15 ( ( PUNCT admet-163 34 16 oatpe oatpe NOUN admet-163 34 17 ) ) PUNCT admet-163 34 18 were be AUX admet-163 34 19 included include VERB admet-163 34 20 as as ADP admet-163 34 21 a a DET admet-163 34 22 control control NOUN admet-163 34 23 as as SCONJ admet-163 34 24 they they PRON admet-163 34 25 are be AUX admet-163 34 26 known know VERB admet-163 34 27 to to PART admet-163 34 28 be be AUX admet-163 34 29 expressed express VERB admet-163 34 30 in in ADP admet-163 34 31 human human ADJ admet-163 34 32 skin skin NOUN admet-163 34 33 [ [ X admet-163 34 34 3,18,19 3,18,19 NUM admet-163 34 35 ] ] PUNCT admet-163 34 36 . . PUNCT admet-163 35 1 furthermore furthermore ADV admet-163 35 2 , , PUNCT admet-163 35 3 the the DET admet-163 35 4 modulation modulation NOUN admet-163 35 5 of of ADP admet-163 35 6 expression expression NOUN admet-163 35 7 of of ADP admet-163 35 8 slc47a1 slc47a1 NOUN admet-163 35 9 and and CCONJ admet-163 35 10 slc47a2 slc47a2 ADV admet-163 35 11 ( ( PUNCT admet-163 35 12 mate mate NOUN admet-163 35 13 family family NOUN admet-163 35 14 ) ) PUNCT admet-163 35 15 transporters transporter NOUN admet-163 35 16 by by ADP admet-163 35 17 rifampicin rifampicin VERB admet-163 35 18 and and CCONJ admet-163 35 19 uv uv NOUN admet-163 35 20 light light ADJ admet-163 35 21 exposure exposure NOUN admet-163 35 22 was be AUX admet-163 35 23 also also ADV admet-163 35 24 evaluated evaluate VERB admet-163 35 25 in in ADP admet-163 35 26 human human ADJ admet-163 35 27 skin skin NOUN admet-163 35 28 in in ADP admet-163 35 29 organ organ NOUN admet-163 35 30 - - PUNCT admet-163 35 31 culture culture NOUN admet-163 35 32 . . PUNCT admet-163 36 1 experimental experimental ADJ admet-163 36 2 chemicals chemical NOUN admet-163 36 3 and and CCONJ admet-163 36 4 reagents reagent NOUN admet-163 36 5 rifampicin rifampicin VERB admet-163 36 6 was be AUX admet-163 36 7 from from ADP admet-163 36 8 sigma sigma PROPN admet-163 36 9 - - PUNCT admet-163 36 10 aldrich aldrich PROPN admet-163 36 11 ( ( PUNCT admet-163 36 12 st st PROPN admet-163 36 13 louis louis PROPN admet-163 36 14 , , PUNCT admet-163 36 15 mo mo PROPN admet-163 36 16 , , PUNCT admet-163 36 17 usa usa PROPN admet-163 36 18 ) ) PUNCT admet-163 36 19 . . PUNCT admet-163 37 1 total total ADJ admet-163 37 2 rna rna PROPN admet-163 37 3 from from ADP admet-163 37 4 human human ADJ admet-163 37 5 kidneys kidney NOUN admet-163 37 6 came come VERB admet-163 37 7 from from ADP admet-163 37 8 life life NOUN admet-163 37 9 technologies technology NOUN admet-163 37 10 ( ( PUNCT admet-163 37 11 carlsbad carlsbad PROPN admet-163 37 12 , , PUNCT admet-163 37 13 ca ca PROPN admet-163 37 14 , , PUNCT admet-163 37 15 usa usa PROPN admet-163 37 16 ) ) PUNCT admet-163 37 17 . . PUNCT admet-163 38 1 skin skin NOUN admet-163 38 2 organ organ NOUN admet-163 38 3 - - PUNCT admet-163 38 4 culture culture NOUN admet-163 38 5 fresh fresh ADJ admet-163 38 6 healthy healthy ADJ admet-163 38 7 human human ADJ admet-163 38 8 skin skin NOUN admet-163 38 9 surgical surgical ADJ admet-163 38 10 waste waste NOUN admet-163 38 11 samples sample NOUN admet-163 38 12 excised excise VERB admet-163 38 13 during during ADP admet-163 38 14 cosmetic cosmetic ADJ admet-163 38 15 surgery surgery NOUN admet-163 38 16 were be AUX admet-163 38 17 collected collect VERB admet-163 38 18 and and CCONJ admet-163 38 19 used use VERB admet-163 38 20 with with ADP admet-163 38 21 the the DET admet-163 38 22 consent consent NOUN admet-163 38 23 of of ADP admet-163 38 24 the the DET admet-163 38 25 patients patient NOUN admet-163 38 26 . . PUNCT admet-163 39 1 skin skin NOUN admet-163 39 2 tissues tissue NOUN admet-163 39 3 were be AUX admet-163 39 4 handled handle VERB admet-163 39 5 under under ADP admet-163 39 6 aseptic aseptic ADJ admet-163 39 7 condition condition NOUN admet-163 39 8 and and CCONJ admet-163 39 9 processed process VERB admet-163 39 10 with with ADP admet-163 39 11 sterile sterile ADJ admet-163 39 12 dissection dissection NOUN admet-163 39 13 tools tool NOUN admet-163 39 14 . . PUNCT admet-163 40 1 after after ADP admet-163 40 2 removing remove VERB admet-163 40 3 adipose adipose ADP admet-163 40 4 tissue tissue NOUN admet-163 40 5 and and CCONJ admet-163 40 6 hypodermis hypodermis NOUN admet-163 40 7 with with ADP admet-163 40 8 surgical surgical ADJ admet-163 40 9 scissors scissor NOUN admet-163 40 10 , , PUNCT admet-163 40 11 skin skin NOUN admet-163 40 12 biopsies biopsy NOUN admet-163 40 13 of of ADP admet-163 40 14 6 6 NUM admet-163 40 15 mm mm NOUN admet-163 40 16 diameter diameter NOUN admet-163 40 17 were be AUX admet-163 40 18 taken take VERB admet-163 40 19 using use VERB admet-163 40 20 sterile sterile ADJ admet-163 40 21 biopsy biopsy NOUN admet-163 40 22 punch punch NOUN admet-163 40 23 tools tool NOUN admet-163 40 24 , , PUNCT admet-163 40 25 and and CCONJ admet-163 40 26 transferred transfer VERB admet-163 40 27 to to ADP admet-163 40 28 a a DET admet-163 40 29 6 6 NUM admet-163 40 30 - - PUNCT admet-163 40 31 well well NOUN admet-163 40 32 plate plate NOUN admet-163 40 33 alriquet alriquet VERB admet-163 40 34 m m PROPN admet-163 40 35 admet admet PROPN admet-163 40 36 & & CCONJ admet-163 40 37 dmpk dmpk PROPN admet-163 40 38 3(1 3(1 NUM admet-163 40 39 ) ) PUNCT admet-163 40 40 ( ( PUNCT admet-163 40 41 2015 2015 NUM admet-163 40 42 ) ) PUNCT admet-163 40 43 34 34 NUM admet-163 40 44 - - SYM admet-163 40 45 44 44 NUM admet-163 40 46 36 36 NUM admet-163 40 47 filled fill VERB admet-163 40 48 with with ADP admet-163 40 49 long long ADJ admet-163 40 50 term term NOUN admet-163 40 51 skin skin NOUN admet-163 40 52 culture culture NOUN admet-163 40 53 medium medium NOUN admet-163 40 54 ( ( PUNCT admet-163 40 55 biopredic biopredic ADJ admet-163 40 56 , , PUNCT admet-163 40 57 france france PROPN admet-163 40 58 ) ) PUNCT admet-163 40 59 . . PUNCT admet-163 41 1 this this DET admet-163 41 2 proprietary proprietary ADJ admet-163 41 3 long long ADJ admet-163 41 4 - - PUNCT admet-163 41 5 term term NOUN admet-163 41 6 skin skin NOUN admet-163 41 7 culture culture NOUN admet-163 41 8 medium medium NOUN admet-163 41 9 has have AUX admet-163 41 10 been be AUX admet-163 41 11 developed develop VERB admet-163 41 12 specifically specifically ADV admet-163 41 13 to to PART admet-163 41 14 maintain maintain VERB admet-163 41 15 the the DET admet-163 41 16 survival survival NOUN admet-163 41 17 of of ADP admet-163 41 18 human human ADJ admet-163 41 19 skin skin NOUN admet-163 41 20 explants explant NOUN admet-163 41 21 . . PUNCT admet-163 42 1 the the DET admet-163 42 2 specific specific ADJ admet-163 42 3 composition composition NOUN admet-163 42 4 of of ADP admet-163 42 5 this this DET admet-163 42 6 medium medium NOUN admet-163 42 7 ( ( PUNCT admet-163 42 8 fetal fetal ADJ admet-163 42 9 calf calf NOUN admet-163 42 10 serum serum NOUN admet-163 42 11 , , PUNCT admet-163 42 12 antibiotics antibiotic NOUN admet-163 42 13 , , PUNCT admet-163 42 14 pituitary pituitary ADJ admet-163 42 15 bovine bovine NOUN admet-163 42 16 extract extract NOUN admet-163 42 17 , , PUNCT admet-163 42 18 sodium sodium NOUN admet-163 42 19 pyruvate pyruvate NOUN admet-163 42 20 , , PUNCT admet-163 42 21 growth growth NOUN admet-163 42 22 factors factor NOUN admet-163 42 23 and and CCONJ admet-163 42 24 hormones hormone NOUN admet-163 42 25 such such ADJ admet-163 42 26 as as ADP admet-163 42 27 insulin insulin NOUN admet-163 42 28 and and CCONJ admet-163 42 29 epidermal epidermal ADJ admet-163 42 30 growth growth NOUN admet-163 42 31 factor factor NOUN admet-163 42 32 , , PUNCT admet-163 42 33 hydrocortisone hydrocortisone NOUN admet-163 42 34 and and CCONJ admet-163 42 35 selenium selenium NOUN admet-163 42 36 ) ) PUNCT admet-163 42 37 allows allow VERB admet-163 42 38 the the DET admet-163 42 39 preservation preservation NOUN admet-163 42 40 of of ADP admet-163 42 41 dermal dermal NOUN admet-163 42 42 and and CCONJ admet-163 42 43 epidermal epidermal ADJ admet-163 42 44 cell cell NOUN admet-163 42 45 populations population NOUN admet-163 42 46 in in ADP admet-163 42 47 normal normal ADJ admet-163 42 48 metabolic metabolic NOUN admet-163 42 49 conditions condition NOUN admet-163 42 50 for for ADP admet-163 42 51 at at ADV admet-163 42 52 least least ADV admet-163 42 53 3 3 NUM admet-163 42 54 days day NOUN admet-163 42 55 . . PUNCT admet-163 43 1 four four NUM admet-163 43 2 biopsies biopsy NOUN admet-163 43 3 per per ADP admet-163 43 4 well well ADV admet-163 43 5 were be AUX admet-163 43 6 used use VERB admet-163 43 7 ( ( PUNCT admet-163 43 8 figure figure NOUN admet-163 43 9 1 1 NUM admet-163 43 10 ) ) PUNCT admet-163 43 11 . . PUNCT admet-163 44 1 the the DET admet-163 44 2 culture culture NOUN admet-163 44 3 plate plate NOUN admet-163 44 4 was be AUX admet-163 44 5 maintained maintain VERB admet-163 44 6 in in ADP admet-163 44 7 a a DET admet-163 44 8 humidified humidify VERB admet-163 44 9 incubator incubator NOUN admet-163 44 10 at at ADP admet-163 44 11 37 37 NUM admet-163 44 12 ° ° NOUN admet-163 44 13 c c NOUN admet-163 44 14 with with ADP admet-163 44 15 5 5 NUM admet-163 44 16 % % NOUN admet-163 44 17 co2 co2 NOUN admet-163 44 18 . . PUNCT admet-163 45 1 figure figure NOUN admet-163 45 2 1 1 NUM admet-163 45 3 . . PUNCT admet-163 46 1 skin skin NOUN admet-163 46 2 organ organ NOUN admet-163 46 3 - - PUNCT admet-163 46 4 culture culture NOUN admet-163 46 5 . . PUNCT admet-163 47 1 skin skin NOUN admet-163 47 2 biopsies biopsy NOUN admet-163 47 3 were be AUX admet-163 47 4 taken take VERB admet-163 47 5 using use VERB admet-163 47 6 biopsy biopsy NOUN admet-163 47 7 punch punch NOUN admet-163 47 8 and and CCONJ admet-163 47 9 transferred transfer VERB admet-163 47 10 to to ADP admet-163 47 11 a a DET admet-163 47 12 6 6 NUM admet-163 47 13 - - PUNCT admet-163 47 14 well well NOUN admet-163 47 15 plate plate NOUN admet-163 47 16 filled fill VERB admet-163 47 17 with with ADP admet-163 47 18 culture culture NOUN admet-163 47 19 medium medium NOUN admet-163 47 20 . . PUNCT admet-163 48 1 treatment treatment NOUN admet-163 48 2 with with ADP admet-163 48 3 rifampicin rifampicin VERB admet-163 48 4 skin skin NOUN admet-163 48 5 biopsies biopsy NOUN admet-163 48 6 were be AUX admet-163 48 7 treated treat VERB admet-163 48 8 during during ADP admet-163 48 9 72 72 NUM admet-163 48 10 hours hour NOUN admet-163 48 11 with with ADP admet-163 48 12 20 20 NUM admet-163 48 13 µm µm NOUN admet-163 48 14 rifampicin rifampicin VERB admet-163 48 15 , , PUNCT admet-163 48 16 refreshing refreshing ADJ admet-163 48 17 culture culture NOUN admet-163 48 18 medium medium NOUN admet-163 48 19 every every DET admet-163 48 20 24 24 NUM admet-163 48 21 hours hour NOUN admet-163 48 22 . . PUNCT admet-163 49 1 control control NOUN admet-163 49 2 skin skin NOUN admet-163 49 3 biopsies biopsy NOUN admet-163 49 4 were be AUX admet-163 49 5 cultured cultured ADJ admet-163 49 6 in in ADP admet-163 49 7 the the DET admet-163 49 8 same same ADJ admet-163 49 9 conditions condition NOUN admet-163 49 10 but but CCONJ admet-163 49 11 rifampicin rifampicin VERB admet-163 49 12 was be AUX admet-163 49 13 omitted omit VERB admet-163 49 14 in in ADP admet-163 49 15 the the DET admet-163 49 16 vehicle vehicle NOUN admet-163 49 17 ( ( PUNCT admet-163 49 18 i.e. i.e. X admet-163 49 19 0.1 0.1 NUM admet-163 49 20 % % NOUN admet-163 49 21 dmso dmso NOUN admet-163 49 22 ) ) PUNCT admet-163 49 23 . . PUNCT admet-163 50 1 during during ADP admet-163 50 2 incubation incubation NOUN admet-163 50 3 , , PUNCT admet-163 50 4 culture culture NOUN admet-163 50 5 plate plate NOUN admet-163 50 6 was be AUX admet-163 50 7 placed place VERB admet-163 50 8 in in ADP admet-163 50 9 a a DET admet-163 50 10 humidified humidify VERB admet-163 50 11 incubator incubator NOUN admet-163 50 12 at at ADP admet-163 50 13 37 37 NUM admet-163 50 14 ° ° NOUN admet-163 50 15 c c NOUN admet-163 50 16 with with ADP admet-163 50 17 5 5 NUM admet-163 50 18 % % NOUN admet-163 50 19 co2 co2 NOUN admet-163 50 20 . . PUNCT admet-163 51 1 skins skin NOUN admet-163 51 2 from from ADP admet-163 51 3 at at ADV admet-163 51 4 least least ADV admet-163 51 5 three three NUM admet-163 51 6 different different ADJ admet-163 51 7 individuals individual NOUN admet-163 51 8 were be AUX admet-163 51 9 used use VERB admet-163 51 10 in in ADP admet-163 51 11 each each DET admet-163 51 12 experiment experiment NOUN admet-163 51 13 unless unless SCONJ admet-163 51 14 mentioned mention VERB admet-163 51 15 . . PUNCT admet-163 52 1 treatment treatment NOUN admet-163 52 2 with with ADP admet-163 52 3 sunlight sunlight NOUN admet-163 52 4 simulator simulator NOUN admet-163 52 5 skin skin NOUN admet-163 52 6 biopsies biopsy NOUN admet-163 52 7 were be AUX admet-163 52 8 exposed expose VERB admet-163 52 9 during during ADP admet-163 52 10 one one NUM admet-163 52 11 hour hour NOUN admet-163 52 12 every every DET admet-163 52 13 day day NOUN admet-163 52 14 during during ADP admet-163 52 15 3 3 NUM admet-163 52 16 days day NOUN admet-163 52 17 in in ADP admet-163 52 18 a a DET admet-163 52 19 sunlight sunlight NOUN admet-163 52 20 simulator simulator NOUN admet-163 52 21 ( ( PUNCT admet-163 52 22 model model NOUN admet-163 52 23 91293 91293 NUM admet-163 52 24 ; ; PUNCT admet-163 52 25 oriel oriel ADJ admet-163 52 26 instruments instrument NOUN admet-163 52 27 ) ) PUNCT admet-163 52 28 equipped equip VERB admet-163 52 29 with with ADP admet-163 52 30 a a DET admet-163 52 31 1000 1000 NUM admet-163 52 32 - - PUNCT admet-163 52 33 w w NOUN admet-163 52 34 xenon xenon NOUN admet-163 52 35 arc arc NOUN admet-163 52 36 lamp lamp PROPN admet-163 52 37 power power NOUN admet-163 52 38 supply supply NOUN admet-163 52 39 set set VERB admet-163 52 40 at at ADP admet-163 52 41 850 850 NUM admet-163 52 42 w. w. NOUN admet-163 52 43 the the DET admet-163 52 44 sunlight sunlight NOUN admet-163 52 45 simulator simulator NOUN admet-163 52 46 dispensed dispense VERB admet-163 52 47 a a DET admet-163 52 48 mix mix NOUN admet-163 52 49 of of ADP admet-163 52 50 uva uva PROPN admet-163 52 51 at at ADP admet-163 52 52 110 110 NUM admet-163 52 53 w w NOUN admet-163 52 54 / / SYM admet-163 52 55 m² m² PROPN admet-163 52 56 and and CCONJ admet-163 52 57 uvb uvb ADJ admet-163 52 58 at at ADP admet-163 52 59 20 20 NUM admet-163 52 60 w w NOUN admet-163 52 61 / / SYM admet-163 52 62 m² m² PROPN admet-163 52 63 which which PRON admet-163 52 64 corresponds correspond VERB admet-163 52 65 to to ADP admet-163 52 66 approximately approximately ADV admet-163 52 67 40 40 NUM admet-163 52 68 j j NOUN admet-163 52 69 / / SYM admet-163 52 70 cm² cm² ADP admet-163 52 71 uva uva PROPN admet-163 52 72 and and CCONJ admet-163 52 73 3.6 3.6 NUM admet-163 52 74 j j NOUN admet-163 52 75 / / SYM admet-163 52 76 cm² cm² ADP admet-163 52 77 uvb uvb ADJ admet-163 52 78 for for ADP admet-163 52 79 a a DET admet-163 52 80 1 1 NUM admet-163 52 81 hour hour NOUN admet-163 52 82 exposure exposure NOUN admet-163 52 83 period period NOUN admet-163 52 84 . . PUNCT admet-163 53 1 control control NOUN admet-163 53 2 skin skin NOUN admet-163 53 3 biopsies biopsy NOUN admet-163 53 4 were be AUX admet-163 53 5 cultured cultured ADJ admet-163 53 6 in in ADP admet-163 53 7 the the DET admet-163 53 8 same same ADJ admet-163 53 9 conditions condition NOUN admet-163 53 10 but but CCONJ admet-163 53 11 without without ADP admet-163 53 12 exposure exposure NOUN admet-163 53 13 in in ADP admet-163 53 14 the the DET admet-163 53 15 sunlight sunlight NOUN admet-163 53 16 simulator simulator NOUN admet-163 53 17 . . PUNCT admet-163 54 1 human human ADJ admet-163 54 2 hepatocytes hepatocyte NOUN admet-163 54 3 in in ADP admet-163 54 4 primary primary ADJ admet-163 54 5 culture culture NOUN admet-163 54 6 fresh fresh ADJ admet-163 54 7 human human ADJ admet-163 54 8 hepatocytes hepatocyte NOUN admet-163 54 9 in in ADP admet-163 54 10 primary primary ADJ admet-163 54 11 culture culture NOUN admet-163 54 12 were be AUX admet-163 54 13 purchased purchase VERB admet-163 54 14 from from ADP admet-163 54 15 biopredic biopredic ADJ admet-163 54 16 ( ( PUNCT admet-163 54 17 france france PROPN admet-163 54 18 ) ) PUNCT admet-163 54 19 . . PUNCT admet-163 55 1 hepatocytes hepatocytes PROPN admet-163 55 2 ( ( PUNCT admet-163 55 3 identification identification NOUN admet-163 55 4 number number NOUN admet-163 55 5 hh0711b hh0711b NOUN admet-163 55 6 ) ) PUNCT admet-163 55 7 were be AUX admet-163 55 8 seeded seed VERB admet-163 55 9 at at ADP admet-163 55 10 1.8 1.8 NUM admet-163 55 11 x x SYM admet-163 55 12 106 106 NUM admet-163 55 13 cells cell NOUN admet-163 55 14 / / SYM admet-163 55 15 well well ADV admet-163 55 16 in in ADP admet-163 55 17 6 6 NUM admet-163 55 18 - - PUNCT admet-163 55 19 well well NOUN admet-163 55 20 plate plate NOUN admet-163 55 21 . . PUNCT admet-163 56 1 each each DET admet-163 56 2 well well ADV admet-163 56 3 was be AUX admet-163 56 4 filled fill VERB admet-163 56 5 with with ADP admet-163 56 6 2 2 NUM admet-163 56 7 ml ml NOUN admet-163 56 8 spfm spfm PROPN admet-163 56 9 culture culture PROPN admet-163 56 10 medium medium PROPN admet-163 56 11 ( ( PUNCT admet-163 56 12 gibco gibco NOUN admet-163 56 13 , , PUNCT admet-163 56 14 france france PROPN admet-163 56 15 ) ) PUNCT admet-163 56 16 . . PUNCT admet-163 57 1 hepatocyte hepatocyte PROPN admet-163 57 2 culture culture NOUN admet-163 57 3 was be AUX admet-163 57 4 maintained maintain VERB admet-163 57 5 during during ADP admet-163 57 6 3 3 NUM admet-163 57 7 days day NOUN admet-163 57 8 in in ADP admet-163 57 9 a a DET admet-163 57 10 humidified humidified ADJ admet-163 57 11 incubator incubator NOUN admet-163 57 12 set set VERB admet-163 57 13 at at ADP admet-163 57 14 37 37 NUM admet-163 57 15 ° ° NOUN admet-163 57 16 c c NOUN admet-163 57 17 with with ADP admet-163 57 18 5 5 NUM admet-163 57 19 % % NOUN admet-163 57 20 co2 co2 NOUN admet-163 57 21 . . PUNCT admet-163 58 1 culture culture NOUN admet-163 58 2 medium medium NOUN admet-163 58 3 was be AUX admet-163 58 4 refreshed refresh VERB admet-163 58 5 every every DET admet-163 58 6 day day NOUN admet-163 58 7 . . PUNCT admet-163 59 1 in in ADP admet-163 59 2 some some DET admet-163 59 3 experiments experiment NOUN admet-163 59 4 , , PUNCT admet-163 59 5 hepatocytes hepatocyte NOUN admet-163 59 6 were be AUX admet-163 59 7 treated treat VERB admet-163 59 8 with with ADP admet-163 59 9 20 20 NUM admet-163 59 10 µm µm NOUN admet-163 59 11 rifampicin rifampicin VERB admet-163 59 12 during during ADP admet-163 59 13 72 72 NUM admet-163 59 14 hours hour NOUN admet-163 59 15 with with ADP admet-163 59 16 refreshing refreshing ADJ admet-163 59 17 culture culture NOUN admet-163 59 18 medium medium NOUN admet-163 59 19 every every DET admet-163 59 20 24 24 NUM admet-163 59 21 hours hour NOUN admet-163 59 22 . . PUNCT admet-163 60 1 cryopreserved cryopreserve VERB admet-163 60 2 human human ADJ admet-163 60 3 hepatocytes hepatocyte NOUN admet-163 60 4 cryopreserved cryopreserve VERB admet-163 60 5 human human ADJ admet-163 60 6 hepatocytes hepatocyte NOUN admet-163 60 7 were be AUX admet-163 60 8 used use VERB admet-163 60 9 to to PART admet-163 60 10 evaluate evaluate VERB admet-163 60 11 constitutive constitutive ADJ admet-163 60 12 expression expression NOUN admet-163 60 13 of of ADP admet-163 60 14 slc slc PROPN admet-163 60 15 transporters transporter NOUN admet-163 60 16 . . PUNCT admet-163 61 1 cryopreserved cryopreserve VERB admet-163 61 2 human human ADJ admet-163 61 3 hepatocytes hepatocyte NOUN admet-163 61 4 , , PUNCT admet-163 61 5 batch batch NOUN admet-163 61 6 number number NOUN admet-163 61 7 hue26c hue26c NOUN admet-163 61 8 from from ADP admet-163 61 9 life life NOUN admet-163 61 10 technologies technology NOUN admet-163 61 11 , , PUNCT admet-163 61 12 consisted consist VERB admet-163 61 13 of of ADP admet-163 61 14 a a DET admet-163 61 15 pool pool NOUN admet-163 61 16 of of ADP admet-163 61 17 26 26 NUM admet-163 61 18 different different ADJ admet-163 61 19 donors donor NOUN admet-163 61 20 . . PUNCT admet-163 62 1 admet admet PROPN admet-163 62 2 & & CCONJ admet-163 62 3 dmpk dmpk PROPN admet-163 62 4 3(1 3(1 NUM admet-163 62 5 ) ) PUNCT admet-163 62 6 ( ( PUNCT admet-163 62 7 2015 2015 NUM admet-163 62 8 ) ) PUNCT admet-163 62 9 34 34 NUM admet-163 62 10 - - SYM admet-163 62 11 44 44 NUM admet-163 62 12 expression expression NOUN admet-163 62 13 of of ADP admet-163 62 14 slc slc PROPN admet-163 62 15 transporters transporter NOUN admet-163 62 16 in in ADP admet-163 62 17 human human ADJ admet-163 62 18 skin skin NOUN admet-163 62 19 doi doi NOUN admet-163 62 20 : : PUNCT admet-163 62 21 10.5599 10.5599 NUM admet-163 62 22 / / SYM admet-163 62 23 admet.3.1.163 admet.3.1.163 NUM admet-163 62 24 37 37 NUM admet-163 62 25 total total ADJ admet-163 62 26 rna rna NOUN admet-163 62 27 isolation isolation NOUN admet-163 62 28 after after ADP admet-163 62 29 homogenization homogenization NOUN admet-163 62 30 of of ADP admet-163 62 31 skin skin NOUN admet-163 62 32 samples sample NOUN admet-163 62 33 or or CCONJ admet-163 62 34 hepatocytes hepatocyte NOUN admet-163 62 35 in in ADP admet-163 62 36 lysis lysis NOUN admet-163 62 37 buffer buffer NOUN admet-163 62 38 ( ( PUNCT admet-163 62 39 promega promega PROPN admet-163 62 40 , , PUNCT admet-163 62 41 france france PROPN admet-163 62 42 ) ) PUNCT admet-163 62 43 , , PUNCT admet-163 62 44 total total ADJ admet-163 62 45 rna rna NOUN admet-163 62 46 was be AUX admet-163 62 47 isolated isolate VERB admet-163 62 48 using use VERB admet-163 62 49 sv sv PROPN admet-163 62 50 total total ADJ admet-163 62 51 rna rna NOUN admet-163 62 52 isolation isolation NOUN admet-163 62 53 system system NOUN admet-163 62 54 ( ( PUNCT admet-163 62 55 promega promega PROPN admet-163 62 56 , , PUNCT admet-163 62 57 france france PROPN admet-163 62 58 ) ) PUNCT admet-163 62 59 according accord VERB admet-163 62 60 to to ADP admet-163 62 61 the the DET admet-163 62 62 instructions instruction NOUN admet-163 62 63 provided provide VERB admet-163 62 64 by by ADP admet-163 62 65 the the DET admet-163 62 66 supplier supplier NOUN admet-163 62 67 . . PUNCT admet-163 63 1 rna rna NOUN admet-163 63 2 concentrations concentration NOUN admet-163 63 3 were be AUX admet-163 63 4 quantified quantify VERB admet-163 63 5 at at ADP admet-163 63 6 260 260 NUM admet-163 63 7 nm nm ADV admet-163 63 8 using use VERB admet-163 63 9 biotek biotek NOUN admet-163 63 10 synergy synergy NOUN admet-163 63 11 2 2 NUM admet-163 63 12 multi multi ADJ admet-163 63 13 - - ADJ admet-163 63 14 mode mode ADJ admet-163 63 15 microplate microplate NOUN admet-163 63 16 . . PUNCT admet-163 64 1 human human ADJ admet-163 64 2 kidney kidney PROPN admet-163 64 3 total total PROPN admet-163 64 4 rna rna PROPN admet-163 64 5 human human PROPN admet-163 64 6 kidney kidney PROPN admet-163 64 7 total total NOUN admet-163 64 8 rna rna NOUN admet-163 64 9 samples sample NOUN admet-163 64 10 were be AUX admet-163 64 11 purchased purchase VERB admet-163 64 12 from from ADP admet-163 64 13 life life NOUN admet-163 64 14 technologies technology NOUN admet-163 64 15 . . PUNCT admet-163 65 1 two two NUM admet-163 65 2 different different ADJ admet-163 65 3 samples sample NOUN admet-163 65 4 of of ADP admet-163 65 5 total total ADJ admet-163 65 6 rna rna NOUN admet-163 65 7 from from ADP admet-163 65 8 two two NUM admet-163 65 9 women woman NOUN admet-163 65 10 were be AUX admet-163 65 11 provided provide VERB admet-163 65 12 at at ADP admet-163 65 13 final final ADJ admet-163 65 14 concentration concentration NOUN admet-163 65 15 1 1 NUM admet-163 65 16 mg mg NUM admet-163 65 17 / / SYM admet-163 65 18 ml ml NOUN admet-163 65 19 in in ADP admet-163 65 20 1 1 NUM admet-163 65 21 mm mm NOUN admet-163 65 22 sodium sodium NOUN admet-163 65 23 citrate citrate NOUN admet-163 65 24 , , PUNCT admet-163 65 25 ph ph VERB admet-163 65 26 6.4 6.4 NUM admet-163 65 27 . . PUNCT admet-163 66 1 rna rna NOUN admet-163 66 2 samples sample NOUN admet-163 66 3 were be AUX admet-163 66 4 stored store VERB admet-163 66 5 at at ADP admet-163 66 6 – – PUNCT admet-163 66 7 80 80 NUM admet-163 66 8 ° ° NOUN admet-163 66 9 c c NOUN admet-163 66 10 . . PUNCT admet-163 67 1 real real ADJ admet-163 67 2 time time NOUN admet-163 67 3 pcr pcr NOUN admet-163 67 4 expression expression NOUN admet-163 67 5 of of ADP admet-163 67 6 eleven eleven NUM admet-163 67 7 human human PROPN admet-163 67 8 slc slc PROPN admet-163 67 9 transporters transporter NOUN admet-163 67 10 ( ( PUNCT admet-163 67 11 slco1b1 slco1b1 NUM admet-163 67 12 , , PUNCT admet-163 67 13 slco1b3 slco1b3 NOUN admet-163 67 14 , , PUNCT admet-163 67 15 slco2b1 slco2b1 NUM admet-163 67 16 , , PUNCT admet-163 67 17 slco3a1 slco3a1 VERB admet-163 67 18 , , PUNCT admet-163 67 19 slco4a1 slco4a1 NOUN admet-163 67 20 , , PUNCT admet-163 67 21 slc22a1 slc22a1 PROPN admet-163 67 22 , , PUNCT admet-163 67 23 slc22a2 slc22a2 NOUN admet-163 67 24 , , PUNCT admet-163 67 25 slc22a6 slc22a6 PROPN admet-163 67 26 , , PUNCT admet-163 67 27 slc22a8 slc22a8 NOUN admet-163 67 28 , , PUNCT admet-163 67 29 slc47a1 slc47a1 NOUN admet-163 67 30 and and CCONJ admet-163 67 31 slc47a2 slc47a2 NUM admet-163 67 32 ) ) PUNCT admet-163 67 33 and and CCONJ admet-163 67 34 4 4 NUM admet-163 67 35 nuclear nuclear ADJ admet-163 67 36 receptors receptor NOUN admet-163 67 37 ( ( PUNCT admet-163 67 38 ahr ahr PROPN admet-163 67 39 , , PUNCT admet-163 67 40 nr113 nr113 PROPN admet-163 67 41 , , PUNCT admet-163 67 42 nr112 nr112 PROPN admet-163 67 43 and and CCONJ admet-163 67 44 rxra rxra PROPN admet-163 67 45 ) ) PUNCT admet-163 67 46 was be AUX admet-163 67 47 measured measure VERB admet-163 67 48 by by ADP admet-163 67 49 real real ADJ admet-163 67 50 - - PUNCT admet-163 67 51 time time NOUN admet-163 67 52 pcr pcr NOUN admet-163 67 53 techniques technique NOUN admet-163 67 54 . . PUNCT admet-163 68 1 experiments experiment NOUN admet-163 68 2 were be AUX admet-163 68 3 carried carry VERB admet-163 68 4 out out ADP admet-163 68 5 on on ADP admet-163 68 6 a a DET admet-163 68 7 7500 7500 NUM admet-163 68 8 real real ADJ admet-163 68 9 - - PUNCT admet-163 68 10 time time NOUN admet-163 68 11 pcr pcr NOUN admet-163 68 12 system system NOUN admet-163 68 13 ( ( PUNCT admet-163 68 14 applied apply VERB admet-163 68 15 biosystems biosystem NOUN admet-163 68 16 ) ) PUNCT admet-163 68 17 using use VERB admet-163 68 18 taqman taqman NOUN admet-163 68 19 assay assay VERB admet-163 68 20 - - PUNCT admet-163 68 21 on on ADP admet-163 68 22 - - PUNCT admet-163 68 23 demand demand NOUN admet-163 68 24 gene gene NOUN admet-163 68 25 expression expression NOUN admet-163 68 26 products product NOUN admet-163 68 27 . . PUNCT admet-163 69 1 for for ADP admet-163 69 2 this this PRON admet-163 69 3 , , PUNCT admet-163 69 4 500 500 NUM admet-163 69 5 ng ng PROPN admet-163 69 6 of of ADP admet-163 69 7 total total ADJ admet-163 69 8 rna rna NOUN admet-163 69 9 were be AUX admet-163 69 10 reverse reverse NOUN admet-163 69 11 - - PUNCT admet-163 69 12 transcribed transcribe VERB admet-163 69 13 using use VERB admet-163 69 14 the the DET admet-163 69 15 high high ADJ admet-163 69 16 capacity capacity NOUN admet-163 69 17 rna rna NOUN admet-163 69 18 to to ADP admet-163 69 19 cdna cdna PROPN admet-163 69 20 master master NOUN admet-163 69 21 mix mix NOUN admet-163 69 22 kit kit NOUN admet-163 69 23 ( ( PUNCT admet-163 69 24 applied apply VERB admet-163 69 25 biosystems biosystem NOUN admet-163 69 26 ) ) PUNCT admet-163 69 27 . . PUNCT admet-163 70 1 table table NOUN admet-163 70 2 1 1 NUM admet-163 70 3 . . PUNCT admet-163 71 1 assay assay VERB admet-163 71 2 - - PUNCT admet-163 71 3 on on ADP admet-163 71 4 - - PUNCT admet-163 71 5 demand demand NOUN admet-163 71 6 used use VERB admet-163 71 7 in in ADP admet-163 71 8 the the DET admet-163 71 9 gene gene NOUN admet-163 71 10 expression expression NOUN admet-163 71 11 profile profile NOUN admet-163 71 12 experiments experiment NOUN admet-163 71 13 . . PUNCT admet-163 72 1 gene gene NOUN admet-163 72 2 / / SYM admet-163 72 3 protein protein NOUN admet-163 72 4 assay assay NOUN admet-163 72 5 - - PUNCT admet-163 72 6 on on ADP admet-163 72 7 - - PUNCT admet-163 72 8 demand demand NOUN admet-163 72 9 reference reference NOUN admet-163 72 10 slco1b1 slco1b1 NUM admet-163 72 11 / / SYM admet-163 72 12 oatp1b1 oatp1b1 PROPN admet-163 72 13 hs00272374_m1 hs00272374_m1 PUNCT admet-163 72 14 slco1b3 slco1b3 PROPN admet-163 72 15 / / SYM admet-163 72 16 oatp1b3 oatp1b3 NOUN admet-163 72 17 hs00251986_m1 hs00251986_m1 NOUN admet-163 72 18 slco2b1 slco2b1 NUM admet-163 72 19 ( ( PUNCT admet-163 72 20 slc21a9)/oatpb slc21a9)/oatpb X admet-163 72 21 hs00939778_m1 hs00939778_m1 NOUN admet-163 72 22 slco3a1 slco3a1 X admet-163 72 23 ( ( PUNCT admet-163 72 24 slc21a11)/oatpd slc21a11)/oatpd VERB admet-163 72 25 hs00983988_m1 hs00983988_m1 X admet-163 72 26 slco4a1 slco4a1 X admet-163 72 27 ( ( PUNCT admet-163 72 28 slc21a12)/oatpe slc21a12)/oatpe PROPN admet-163 72 29 hs01030343_m1 hs01030343_m1 PUNCT admet-163 72 30 slc22a1 slc22a1 PROPN admet-163 72 31 / / SYM admet-163 72 32 oct1 oct1 NOUN admet-163 72 33 hs00427552_m1 hs00427552_m1 PUNCT admet-163 72 34 slc22a2 slc22a2 NOUN admet-163 72 35 / / SYM admet-163 72 36 oct2 oct2 PROPN admet-163 72 37 hs01010723_m1 hs01010723_m1 PUNCT admet-163 73 1 slc22a6 slc22a6 PROPN admet-163 73 2 / / SYM admet-163 73 3 oat1 oat1 PROPN admet-163 73 4 hs00537914_m1 hs00537914_m1 X admet-163 73 5 slc22a8 slc22a8 PROPN admet-163 73 6 / / SYM admet-163 73 7 oat3 oat3 PROPN admet-163 73 8 hs00188599_m1 hs00188599_m1 PUNCT admet-163 73 9 slc47a1 slc47a1 PROPN admet-163 73 10 / / SYM admet-163 73 11 mate1 mate1 NOUN admet-163 73 12 hs00217320_m1 hs00217320_m1 PUNCT admet-163 74 1 slc47a2 slc47a2 ADV admet-163 74 2 / / SYM admet-163 74 3 mate2 mate2 NOUN admet-163 74 4 hs00945650_m1 hs00945650_m1 X admet-163 75 1 ahr ahr PROPN admet-163 75 2 / / SYM admet-163 75 3 ahr ahr PROPN admet-163 75 4 hs00169233_m1 hs00169233_m1 PUNCT admet-163 76 1 nr1i3 nr1i3 NOUN admet-163 76 2 / / SYM admet-163 76 3 car car NOUN admet-163 76 4 hs00231959_m1 hs00231959_m1 PUNCT admet-163 77 1 nr1i2 nr1i2 X admet-163 77 2 / / SYM admet-163 77 3 pxr pxr NOUN admet-163 77 4 hs01114267_m1 hs01114267_m1 X admet-163 77 5 rxra rxra NOUN admet-163 77 6 / / SYM admet-163 77 7 rxrα rxrα NOUN admet-163 77 8 hs01067636_m1 hs01067636_m1 NOUN admet-163 77 9 gapdh gapdh NOUN admet-163 77 10 hs99999905_m1 hs99999905_m1 PUNCT admet-163 77 11 alriquet alriquet PROPN admet-163 77 12 m m PROPN admet-163 77 13 admet admet PROPN admet-163 77 14 & & CCONJ admet-163 77 15 dmpk dmpk PROPN admet-163 77 16 3(1 3(1 NUM admet-163 77 17 ) ) PUNCT admet-163 77 18 ( ( PUNCT admet-163 77 19 2015 2015 NUM admet-163 77 20 ) ) PUNCT admet-163 77 21 34 34 NUM admet-163 77 22 - - SYM admet-163 77 23 44 44 NUM admet-163 77 24 38 38 NUM admet-163 77 25 pcr pcr ADJ admet-163 77 26 amplifications amplification NOUN admet-163 77 27 were be AUX admet-163 77 28 performed perform VERB admet-163 77 29 in in ADP admet-163 77 30 a a DET admet-163 77 31 total total ADJ admet-163 77 32 volume volume NOUN admet-163 77 33 of of ADP admet-163 77 34 25 25 NUM admet-163 77 35 µl µl ADP admet-163 77 36 using use VERB admet-163 77 37 the the DET admet-163 77 38 taqman taqman NOUN admet-163 77 39 universal universal ADJ admet-163 77 40 master master NOUN admet-163 77 41 mix mix NOUN admet-163 77 42 ( ( PUNCT admet-163 77 43 applied apply VERB admet-163 77 44 biosystems biosystem NOUN admet-163 77 45 ) ) PUNCT admet-163 77 46 . . PUNCT admet-163 78 1 denaturation denaturation PROPN admet-163 78 2 was be AUX admet-163 78 3 performed perform VERB admet-163 78 4 at at ADP admet-163 78 5 95 95 NUM admet-163 78 6 ° ° ADP admet-163 78 7 c c NOUN admet-163 78 8 for for ADP admet-163 78 9 10 10 NUM admet-163 78 10 min min NOUN admet-163 78 11 , , PUNCT admet-163 78 12 followed follow VERB admet-163 78 13 by by ADP admet-163 78 14 40 40 NUM admet-163 78 15 pcr pcr NOUN admet-163 78 16 cycles cycle NOUN admet-163 78 17 with with ADP admet-163 78 18 the the DET admet-163 78 19 following follow VERB admet-163 78 20 specifications specification NOUN admet-163 78 21 : : PUNCT admet-163 78 22 95 95 NUM admet-163 78 23 ° ° NUM admet-163 78 24 c c NOUN admet-163 78 25 15 15 NUM admet-163 78 26 s s NOUN admet-163 78 27 and and CCONJ admet-163 78 28 60 60 NUM admet-163 78 29 ° ° NOUN admet-163 78 30 c c PROPN admet-163 78 31 60 60 NUM admet-163 78 32 s. s. PROPN admet-163 78 33 glyceraldehyde-3 glyceraldehyde-3 VERB admet-163 78 34 - - ADJ admet-163 78 35 phosphate phosphate ADJ admet-163 78 36 dehydrogenase dehydrogenase NOUN admet-163 78 37 ( ( PUNCT admet-163 78 38 gapdh gapdh NOUN admet-163 78 39 ) ) PUNCT admet-163 78 40 was be AUX admet-163 78 41 used use VERB admet-163 78 42 as as ADP admet-163 78 43 a a DET admet-163 78 44 reference reference NOUN admet-163 78 45 gene gene NOUN admet-163 78 46 for for ADP admet-163 78 47 normalization normalization NOUN admet-163 78 48 in in ADP admet-163 78 49 each each DET admet-163 78 50 sample sample NOUN admet-163 78 51 . . PUNCT admet-163 79 1 the the DET admet-163 79 2 references reference NOUN admet-163 79 3 of of ADP admet-163 79 4 primer primer NOUN admet-163 79 5 and and CCONJ admet-163 79 6 taqman taqman NOUN admet-163 79 7 probe probe NOUN admet-163 79 8 sequences sequence NOUN admet-163 79 9 used use VERB admet-163 79 10 in in ADP admet-163 79 11 the the DET admet-163 79 12 expression expression NOUN admet-163 79 13 profiling profiling NOUN admet-163 79 14 experiments experiment NOUN admet-163 79 15 are be AUX admet-163 79 16 indicated indicate VERB admet-163 79 17 in in ADP admet-163 79 18 table table NOUN admet-163 79 19 1 1 NUM admet-163 79 20 . . PUNCT admet-163 80 1 all all DET admet-163 80 2 real real ADJ admet-163 80 3 - - PUNCT admet-163 80 4 time time NOUN admet-163 80 5 pcr pcr ADJ admet-163 80 6 measurements measurement NOUN admet-163 80 7 were be AUX admet-163 80 8 performed perform VERB admet-163 80 9 in in ADP admet-163 80 10 triplicate triplicate NOUN admet-163 80 11 . . PUNCT admet-163 81 1 the the DET admet-163 81 2 comparative comparative ADJ admet-163 81 3 threshold threshold NOUN admet-163 81 4 cycle cycle NOUN admet-163 81 5 ( ( PUNCT admet-163 81 6 ct ct NOUN admet-163 81 7 ) ) PUNCT admet-163 81 8 method method NOUN admet-163 81 9 , , PUNCT admet-163 81 10 also also ADV admet-163 81 11 called call VERB admet-163 81 12 delta delta NOUN admet-163 81 13 ct ct PROPN admet-163 81 14 method method NOUN admet-163 81 15 was be AUX admet-163 81 16 used use VERB admet-163 81 17 to to PART admet-163 81 18 analyse analyse VERB admet-163 81 19 the the DET admet-163 81 20 real real ADJ admet-163 81 21 time time NOUN admet-163 81 22 pcr pcr PROPN admet-163 81 23 data datum NOUN admet-163 81 24 . . PUNCT admet-163 82 1 statistical statistical ADJ admet-163 82 2 analysis analysis NOUN admet-163 82 3 all all DET admet-163 82 4 experiments experiment NOUN admet-163 82 5 were be AUX admet-163 82 6 performed perform VERB admet-163 82 7 at at ADP admet-163 82 8 least least ADV admet-163 82 9 three three NUM admet-163 82 10 times time NOUN admet-163 82 11 . . PUNCT admet-163 83 1 data datum NOUN admet-163 83 2 are be AUX admet-163 83 3 expressed express VERB admet-163 83 4 as as ADP admet-163 83 5 mean mean PROPN admet-163 83 6 ± ± NUM admet-163 83 7 sem sem PROPN admet-163 83 8 . . PUNCT admet-163 84 1 student student PROPN admet-163 84 2 ’s ’s PART admet-163 84 3 t t PROPN admet-163 84 4 - - PUNCT admet-163 84 5 test test NOUN admet-163 84 6 was be AUX admet-163 84 7 used use VERB admet-163 84 8 to to PART admet-163 84 9 determine determine VERB admet-163 84 10 the the DET admet-163 84 11 statistical statistical ADJ admet-163 84 12 significance significance NOUN admet-163 84 13 of of ADP admet-163 84 14 differences difference NOUN admet-163 84 15 between between ADP admet-163 84 16 two two NUM admet-163 84 17 groups group NOUN admet-163 84 18 . . PUNCT admet-163 85 1 a a DET admet-163 85 2 p p NOUN admet-163 85 3 value value NOUN admet-163 85 4 of of ADP admet-163 85 5 less less ADJ admet-163 85 6 than than ADP admet-163 85 7 0.05 0.05 NUM admet-163 85 8 was be AUX admet-163 85 9 considered consider VERB admet-163 85 10 as as ADP admet-163 85 11 statistically statistically ADV admet-163 85 12 significant significant ADJ admet-163 85 13 . . PUNCT admet-163 86 1 results result NOUN admet-163 86 2 gene gene NOUN admet-163 86 3 expression expression NOUN admet-163 86 4 of of ADP admet-163 86 5 slc slc PROPN admet-163 86 6 transporters transporter NOUN admet-163 86 7 in in ADP admet-163 86 8 human human ADJ admet-163 86 9 skin skin NOUN admet-163 86 10 the the DET admet-163 86 11 expression expression NOUN admet-163 86 12 of of ADP admet-163 86 13 11 11 NUM admet-163 86 14 slc slc PROPN admet-163 86 15 transporters transporter NOUN admet-163 86 16 ( ( PUNCT admet-163 86 17 8 8 NUM admet-163 86 18 of of ADP admet-163 86 19 clinically clinically ADV admet-163 86 20 importance importance NOUN admet-163 86 21 in in ADP admet-163 86 22 drug drug NOUN admet-163 86 23 - - PUNCT admet-163 86 24 drug drug NOUN admet-163 86 25 interactions interaction NOUN admet-163 86 26 and and CCONJ admet-163 86 27 three three NUM admet-163 86 28 controls control NOUN admet-163 86 29 ) ) PUNCT admet-163 86 30 was be AUX admet-163 86 31 measured measure VERB admet-163 86 32 in in ADP admet-163 86 33 human human ADJ admet-163 86 34 skin skin NOUN admet-163 86 35 ( ( PUNCT admet-163 86 36 three three NUM admet-163 86 37 different different ADJ admet-163 86 38 donors donor NOUN admet-163 86 39 ) ) PUNCT admet-163 86 40 by by ADP admet-163 86 41 real real ADJ admet-163 86 42 time time NOUN admet-163 86 43 pcr pcr PROPN admet-163 86 44 ( ( PUNCT admet-163 86 45 figure figure NOUN admet-163 86 46 2a 2a NUM admet-163 86 47 ) ) PUNCT admet-163 86 48 . . PUNCT admet-163 87 1 among among ADP admet-163 87 2 the the DET admet-163 87 3 11 11 NUM admet-163 87 4 tested test VERB admet-163 87 5 transporters transporter NOUN admet-163 87 6 , , PUNCT admet-163 87 7 the the DET admet-163 87 8 expression expression NOUN admet-163 87 9 of of ADP admet-163 87 10 six six NUM admet-163 87 11 slc slc PROPN admet-163 87 12 transporters transporter NOUN admet-163 87 13 was be AUX admet-163 87 14 not not PART admet-163 87 15 detected detect VERB admet-163 87 16 in in ADP admet-163 87 17 human human ADJ admet-163 87 18 skin skin NOUN admet-163 87 19 ( ( PUNCT admet-163 87 20 oatp1b1 oatp1b1 NUM admet-163 87 21 , , PUNCT admet-163 87 22 oatp1b3 oatp1b3 NOUN admet-163 87 23 , , PUNCT admet-163 87 24 oct1 oct1 NOUN admet-163 87 25 , , PUNCT admet-163 87 26 oct2 oct2 NOUN admet-163 87 27 , , PUNCT admet-163 87 28 oat1 oat1 PROPN admet-163 87 29 and and CCONJ admet-163 87 30 oat3 oat3 PROPN admet-163 87 31 ) ) PUNCT admet-163 87 32 while while SCONJ admet-163 87 33 the the DET admet-163 87 34 expression expression NOUN admet-163 87 35 of of ADP admet-163 87 36 5 5 NUM admet-163 87 37 slc slc PROPN admet-163 87 38 transporters transporter NOUN admet-163 87 39 was be AUX admet-163 87 40 observed observe VERB admet-163 87 41 . . PUNCT admet-163 88 1 oatpb oatpb PROPN admet-163 88 2 , , PUNCT admet-163 88 3 oatpd oatpd ADJ admet-163 88 4 and and CCONJ admet-163 88 5 mate2 mate2 NOUN admet-163 88 6 were be AUX admet-163 88 7 found find VERB admet-163 88 8 to to PART admet-163 88 9 be be AUX admet-163 88 10 poorly poorly ADV admet-163 88 11 expressed express VERB admet-163 88 12 while while SCONJ admet-163 88 13 two two NUM admet-163 88 14 slc slc PROPN admet-163 88 15 transporters transporter NOUN admet-163 88 16 oatpe oatpe VERB admet-163 88 17 and and CCONJ admet-163 88 18 mate1 mate1 NOUN admet-163 88 19 were be AUX admet-163 88 20 found find VERB admet-163 88 21 to to PART admet-163 88 22 be be AUX admet-163 88 23 highly highly ADV admet-163 88 24 expressed express VERB admet-163 88 25 . . PUNCT admet-163 89 1 data datum NOUN admet-163 89 2 from from ADP admet-163 89 3 our our PRON admet-163 89 4 laboratory laboratory NOUN admet-163 89 5 showed show VERB admet-163 89 6 that that SCONJ admet-163 89 7 expression expression NOUN admet-163 89 8 level level NOUN admet-163 89 9 of of ADP admet-163 89 10 mate1 mate1 NOUN admet-163 89 11 transporters transporter NOUN admet-163 89 12 gene gene NOUN admet-163 89 13 was be AUX admet-163 89 14 not not PART admet-163 89 15 markedly markedly ADV admet-163 89 16 modified modify VERB admet-163 89 17 in in ADP admet-163 89 18 cultured cultured ADJ admet-163 89 19 skin skin NOUN admet-163 89 20 samples sample NOUN admet-163 89 21 ( ( PUNCT admet-163 89 22 ct ct NOUN admet-163 89 23 26.6 26.6 NUM admet-163 89 24 ) ) PUNCT admet-163 89 25 compared compare VERB admet-163 89 26 to to ADP admet-163 89 27 tissues tissue NOUN admet-163 89 28 without without ADP admet-163 89 29 culture culture NOUN admet-163 89 30 ( ( PUNCT admet-163 89 31 ct ct PROPN admet-163 89 32 25.1 25.1 NUM admet-163 89 33 ) ) PUNCT admet-163 89 34 ( ( PUNCT admet-163 89 35 data datum NOUN admet-163 89 36 not not PART admet-163 89 37 shown show VERB admet-163 89 38 ) ) PUNCT admet-163 89 39 . . PUNCT admet-163 90 1 these these DET admet-163 90 2 results result NOUN admet-163 90 3 show show VERB admet-163 90 4 that that SCONJ admet-163 90 5 some some PRON admet-163 90 6 of of ADP admet-163 90 7 slc slc PROPN admet-163 90 8 transporter transporter NOUN admet-163 90 9 involved involve VERB admet-163 90 10 in in ADP admet-163 90 11 clinically clinically ADV admet-163 90 12 relevant relevant ADJ admet-163 90 13 drug drug NOUN admet-163 90 14 - - PUNCT admet-163 90 15 drug drug NOUN admet-163 90 16 interactions interaction NOUN admet-163 90 17 for for ADP admet-163 90 18 systemic systemic ADJ admet-163 90 19 drugs drug NOUN admet-163 90 20 are be AUX admet-163 90 21 expressed express VERB admet-163 90 22 in in ADP admet-163 90 23 human human ADJ admet-163 90 24 skin skin NOUN admet-163 90 25 and and CCONJ admet-163 90 26 that that SCONJ admet-163 90 27 human human ADJ admet-163 90 28 skin skin NOUN admet-163 90 29 in in ADP admet-163 90 30 organ organ NOUN admet-163 90 31 - - PUNCT admet-163 90 32 culture culture NOUN admet-163 90 33 is be AUX admet-163 90 34 a a DET admet-163 90 35 useful useful ADJ admet-163 90 36 tool tool NOUN admet-163 90 37 to to PART admet-163 90 38 study study VERB admet-163 90 39 the the DET admet-163 90 40 involvement involvement NOUN admet-163 90 41 of of ADP admet-163 90 42 slc slc PROPN admet-163 90 43 transporters transporter NOUN admet-163 90 44 in in ADP admet-163 90 45 the the DET admet-163 90 46 absorption absorption NOUN admet-163 90 47 and and CCONJ admet-163 90 48 distribution distribution NOUN admet-163 90 49 of of ADP admet-163 90 50 topically topically ADV admet-163 90 51 applied apply VERB admet-163 90 52 drugs drug NOUN admet-163 90 53 . . PUNCT admet-163 91 1 comparison comparison NOUN admet-163 91 2 of of ADP admet-163 91 3 expression expression NOUN admet-163 91 4 of of ADP admet-163 91 5 slc slc PROPN admet-163 91 6 transporters transporter NOUN admet-163 91 7 in in ADP admet-163 91 8 human human ADJ admet-163 91 9 skin skin NOUN admet-163 91 10 , , PUNCT admet-163 91 11 hepatocytes hepatocyte NOUN admet-163 91 12 and and CCONJ admet-163 91 13 kidney kidney NOUN admet-163 91 14 liver liver NOUN admet-163 91 15 and and CCONJ admet-163 91 16 kidney kidney NOUN admet-163 91 17 tissues tissue NOUN admet-163 91 18 were be AUX admet-163 91 19 used use VERB admet-163 91 20 as as ADP admet-163 91 21 a a DET admet-163 91 22 positive positive ADJ admet-163 91 23 control control NOUN admet-163 91 24 because because SCONJ admet-163 91 25 strong strong ADJ admet-163 91 26 expression expression NOUN admet-163 91 27 of of ADP admet-163 91 28 slc slc PROPN admet-163 91 29 transporters transporter NOUN admet-163 91 30 has have AUX admet-163 91 31 been be AUX admet-163 91 32 described describe VERB admet-163 91 33 previously previously ADV admet-163 91 34 in in ADP admet-163 91 35 these these DET admet-163 91 36 organs organ NOUN admet-163 92 1 [ [ X admet-163 92 2 23 23 NUM admet-163 92 3 ] ] PUNCT admet-163 92 4 . . PUNCT admet-163 93 1 the the DET admet-163 93 2 results result NOUN admet-163 93 3 show show VERB admet-163 93 4 that that SCONJ admet-163 93 5 the the DET admet-163 93 6 expression expression NOUN admet-163 93 7 profiles profile NOUN admet-163 93 8 of of ADP admet-163 93 9 slc slc PROPN admet-163 93 10 transporters transporter NOUN admet-163 93 11 are be AUX admet-163 93 12 specific specific ADJ admet-163 93 13 to to ADP admet-163 93 14 the the DET admet-163 93 15 organ organ NOUN admet-163 93 16 considered consider VERB admet-163 93 17 . . PUNCT admet-163 94 1 in in ADP admet-163 94 2 human human ADJ admet-163 94 3 cryopreserved cryopreserved ADJ admet-163 94 4 hepatocytes hepatocyte NOUN admet-163 94 5 oct1 oct1 PROPN admet-163 94 6 and and CCONJ admet-163 94 7 oatp1b1 oatp1b1 NUM admet-163 94 8 transporters transporter NOUN admet-163 94 9 are be AUX admet-163 94 10 the the DET admet-163 94 11 most most ADV admet-163 94 12 strongly strongly ADV admet-163 94 13 expressed express VERB admet-163 94 14 ( ( PUNCT admet-163 94 15 figure figure NOUN admet-163 94 16 2b 2b NOUN admet-163 94 17 ; ; PUNCT admet-163 94 18 middle middle ADJ admet-163 94 19 ) ) PUNCT admet-163 94 20 while while SCONJ admet-163 94 21 in in ADP admet-163 94 22 human human ADJ admet-163 94 23 kidney kidney NOUN admet-163 94 24 ( ( PUNCT admet-163 94 25 figure figure NOUN admet-163 94 26 2c 2c NOUN admet-163 94 27 ; ; PUNCT admet-163 94 28 bottom bottom NOUN admet-163 94 29 ) ) PUNCT admet-163 94 30 , , PUNCT admet-163 94 31 it it PRON admet-163 94 32 is be AUX admet-163 94 33 oat1 oat1 NOUN admet-163 94 34 and and CCONJ admet-163 94 35 oat3 oat3 PROPN admet-163 94 36 . . PUNCT admet-163 95 1 moreover moreover ADV admet-163 95 2 , , PUNCT admet-163 95 3 oatpe oatpe VERB admet-163 95 4 expression expression NOUN admet-163 95 5 in in ADP admet-163 95 6 human human ADJ admet-163 95 7 skin skin NOUN admet-163 95 8 is be AUX admet-163 95 9 70 70 NUM admet-163 95 10 times time NOUN admet-163 95 11 higher high ADJ admet-163 95 12 than than ADP admet-163 95 13 in in ADP admet-163 95 14 human human ADJ admet-163 95 15 hepatocytes hepatocyte NOUN admet-163 95 16 and and CCONJ admet-163 95 17 as as ADV admet-163 95 18 high high ADJ admet-163 95 19 as as ADP admet-163 95 20 in in ADP admet-163 95 21 human human ADJ admet-163 95 22 kidney kidney NOUN admet-163 95 23 . . PUNCT admet-163 96 1 effect effect NOUN admet-163 96 2 of of ADP admet-163 96 3 rifampicin rifampicin VERB admet-163 96 4 on on ADP admet-163 96 5 gene gene NOUN admet-163 96 6 expression expression NOUN admet-163 96 7 of of ADP admet-163 96 8 slc slc PROPN admet-163 96 9 transporters transporter NOUN admet-163 96 10 in in ADP admet-163 96 11 human human ADJ admet-163 96 12 skin skin NOUN admet-163 96 13 previous previous ADJ admet-163 96 14 studies study NOUN admet-163 96 15 showed show VERB admet-163 96 16 that that SCONJ admet-163 96 17 treatment treatment NOUN admet-163 96 18 with with ADP admet-163 96 19 rifampicin rifampicin VERB admet-163 96 20 decreased decrease VERB admet-163 96 21 the the DET admet-163 96 22 expression expression NOUN admet-163 96 23 level level NOUN admet-163 96 24 of of ADP admet-163 96 25 abcc1 abcc1 PROPN admet-163 96 26 ( ( PUNCT admet-163 96 27 mrp1 mrp1 PROPN admet-163 96 28 ) ) PUNCT admet-163 96 29 in in ADP admet-163 96 30 human human ADJ admet-163 96 31 skin skin NOUN admet-163 96 32 [ [ X admet-163 96 33 17 17 NUM admet-163 96 34 ] ] PUNCT admet-163 96 35 and and CCONJ admet-163 96 36 in in ADP admet-163 96 37 hepg2 hepg2 NOUN admet-163 96 38 cells cell NOUN admet-163 96 39 [ [ X admet-163 96 40 24 24 NUM admet-163 96 41 ] ] PUNCT admet-163 96 42 . . PUNCT admet-163 97 1 the the DET admet-163 97 2 effect effect NOUN admet-163 97 3 of of ADP admet-163 97 4 rifampicin rifampicin VERB admet-163 97 5 on on ADP admet-163 97 6 the the DET admet-163 97 7 expression expression NOUN admet-163 97 8 of of ADP admet-163 97 9 slc slc PROPN admet-163 97 10 transporters transporter NOUN admet-163 97 11 was be AUX admet-163 97 12 thus thus ADV admet-163 97 13 investigated investigate VERB admet-163 97 14 . . PUNCT admet-163 98 1 after after ADP admet-163 98 2 72 72 NUM admet-163 98 3 hours hour NOUN admet-163 98 4 treatment treatment NOUN admet-163 98 5 of of ADP admet-163 98 6 skin skin NOUN admet-163 98 7 samples sample NOUN admet-163 98 8 with with ADP admet-163 98 9 rifampicin rifampicin VERB admet-163 98 10 20 20 NUM admet-163 98 11 µm µm NOUN admet-163 98 12 , , PUNCT admet-163 98 13 gene gene NOUN admet-163 98 14 expression expression NOUN admet-163 98 15 of of ADP admet-163 98 16 slc slc PROPN admet-163 98 17 transporters transporter NOUN admet-163 98 18 was be AUX admet-163 98 19 measured measure VERB admet-163 98 20 by by ADP admet-163 98 21 real real ADJ admet-163 98 22 time time NOUN admet-163 98 23 pcr pcr PROPN admet-163 98 24 . . PUNCT admet-163 99 1 admet admet PROPN admet-163 99 2 & & CCONJ admet-163 99 3 dmpk dmpk PROPN admet-163 99 4 3(1 3(1 NUM admet-163 99 5 ) ) PUNCT admet-163 99 6 ( ( PUNCT admet-163 99 7 2015 2015 NUM admet-163 99 8 ) ) PUNCT admet-163 99 9 34 34 NUM admet-163 99 10 - - SYM admet-163 99 11 44 44 NUM admet-163 99 12 expression expression NOUN admet-163 99 13 of of ADP admet-163 99 14 slc slc PROPN admet-163 99 15 transporters transporter NOUN admet-163 99 16 in in ADP admet-163 99 17 human human ADJ admet-163 99 18 skin skin NOUN admet-163 99 19 doi doi NOUN admet-163 99 20 : : PUNCT admet-163 99 21 10.5599 10.5599 NUM admet-163 99 22 / / SYM admet-163 99 23 admet.3.1.163 admet.3.1.163 PROPN admet-163 99 24 39 39 NUM admet-163 99 25 a a DET admet-163 99 26 : : PUNCT admet-163 99 27 human human ADJ admet-163 99 28 skin skin NOUN admet-163 99 29 ( ( PUNCT admet-163 99 30 data datum NOUN admet-163 99 31 from from ADP admet-163 99 32 three three NUM admet-163 99 33 donors donor NOUN admet-163 99 34 ) ) PUNCT admet-163 100 1 b b X admet-163 100 2 : : PUNCT admet-163 100 3 human human ADJ admet-163 100 4 hepatocytes hepatocyte NOUN admet-163 100 5 ( ( PUNCT admet-163 100 6 pool pool NOUN admet-163 100 7 of of ADP admet-163 100 8 26 26 NUM admet-163 100 9 donors donor NOUN admet-163 100 10 ) ) PUNCT admet-163 101 1 c c X admet-163 101 2 : : PUNCT admet-163 101 3 human human ADJ admet-163 101 4 kidney kidney NOUN admet-163 101 5 ( ( PUNCT admet-163 101 6 data datum NOUN admet-163 101 7 from from ADP admet-163 101 8 2 2 NUM admet-163 101 9 donors donor NOUN admet-163 101 10 ) ) PUNCT admet-163 101 11 figure figure NOUN admet-163 101 12 2 2 NUM admet-163 101 13 . . NOUN admet-163 101 14 constitutive constitutive ADJ admet-163 101 15 expression expression NOUN admet-163 101 16 of of ADP admet-163 101 17 some some DET admet-163 101 18 slc slc PROPN admet-163 101 19 transporters transporter NOUN admet-163 101 20 in in ADP admet-163 101 21 human human ADJ admet-163 101 22 skin skin NOUN admet-163 101 23 ( ( PUNCT admet-163 101 24 a a X admet-163 101 25 ) ) PUNCT admet-163 101 26 , , PUNCT admet-163 101 27 human human ADJ admet-163 101 28 hepatocytes hepatocyte NOUN admet-163 101 29 ( ( PUNCT admet-163 101 30 b b NOUN admet-163 101 31 ) ) PUNCT admet-163 101 32 and and CCONJ admet-163 101 33 human human ADJ admet-163 101 34 kidney kidney NOUN admet-163 101 35 ( ( PUNCT admet-163 101 36 c c NOUN admet-163 101 37 ) ) PUNCT admet-163 101 38 . . PUNCT admet-163 102 1 quantitative quantitative ADJ admet-163 102 2 real real ADJ admet-163 102 3 - - PUNCT admet-163 102 4 time time NOUN admet-163 102 5 reverse reverse ADJ admet-163 102 6 transcription transcription NOUN admet-163 102 7 - - PUNCT admet-163 102 8 pcr pcr NOUN admet-163 102 9 was be AUX admet-163 102 10 used use VERB admet-163 102 11 to to PART admet-163 102 12 investigate investigate VERB admet-163 102 13 the the DET admet-163 102 14 constitutive constitutive ADJ admet-163 102 15 expression expression NOUN admet-163 102 16 of of ADP admet-163 102 17 slc slc PROPN admet-163 102 18 transporters transporter NOUN admet-163 102 19 in in ADP admet-163 102 20 human human ADJ admet-163 102 21 tissues tissue NOUN admet-163 102 22 . . PUNCT admet-163 103 1 gene gene NOUN admet-163 103 2 expression expression NOUN admet-163 103 3 was be AUX admet-163 103 4 normalized normalize VERB admet-163 103 5 to to PART admet-163 103 6 gapdh gapdh VERB admet-163 103 7 to to PART admet-163 103 8 ensure ensure VERB admet-163 103 9 equality equality NOUN admet-163 103 10 of of ADP admet-163 103 11 loading loading NOUN admet-163 103 12 . . PUNCT admet-163 104 1 all all DET admet-163 104 2 analyses analysis NOUN admet-163 104 3 were be AUX admet-163 104 4 performed perform VERB admet-163 104 5 in in ADP admet-163 104 6 triplicate triplicate NOUN admet-163 104 7 . . PUNCT admet-163 105 1 results result NOUN admet-163 105 2 are be AUX admet-163 105 3 means mean NOUN admet-163 105 4 and and CCONJ admet-163 105 5 standard standard ADJ admet-163 105 6 error error NOUN admet-163 105 7 of of ADP admet-163 105 8 3 3 NUM admet-163 105 9 individual individual ADJ admet-163 105 10 skin skin NOUN admet-163 105 11 samples sample NOUN admet-163 105 12 from from ADP admet-163 105 13 3 3 NUM admet-163 105 14 different different ADJ admet-163 105 15 donors donor NOUN admet-163 105 16 , , PUNCT admet-163 105 17 one one NUM admet-163 105 18 hepatocyte hepatocyte NOUN admet-163 105 19 pool pool NOUN admet-163 105 20 of of ADP admet-163 105 21 26 26 NUM admet-163 105 22 donors donor NOUN admet-163 105 23 , , PUNCT admet-163 105 24 or or CCONJ admet-163 105 25 2 2 NUM admet-163 105 26 kidney kidney NOUN admet-163 105 27 mrna mrna VERB admet-163 105 28 from from ADP admet-163 105 29 2 2 NUM admet-163 105 30 donors donor NOUN admet-163 105 31 . . PUNCT admet-163 106 1 all all DET admet-163 106 2 measures measure NOUN admet-163 106 3 were be AUX admet-163 106 4 done do VERB admet-163 106 5 in in ADP admet-163 106 6 triplicate triplicate NOUN admet-163 106 7 . . PUNCT admet-163 107 1 alriquet alriquet PROPN admet-163 107 2 m m PROPN admet-163 107 3 admet admet PROPN admet-163 107 4 & & CCONJ admet-163 107 5 dmpk dmpk PROPN admet-163 107 6 3(1 3(1 NUM admet-163 107 7 ) ) PUNCT admet-163 107 8 ( ( PUNCT admet-163 107 9 2015 2015 NUM admet-163 107 10 ) ) PUNCT admet-163 107 11 34 34 NUM admet-163 107 12 - - SYM admet-163 107 13 44 44 NUM admet-163 107 14 40 40 NUM admet-163 107 15 the the DET admet-163 107 16 results result NOUN admet-163 107 17 presented present VERB admet-163 107 18 in in ADP admet-163 107 19 figure figure NOUN admet-163 107 20 3 3 NUM admet-163 107 21 show show VERB admet-163 107 22 that that SCONJ admet-163 107 23 treatment treatment NOUN admet-163 107 24 of of ADP admet-163 107 25 skin skin NOUN admet-163 107 26 samples sample NOUN admet-163 107 27 with with ADP admet-163 107 28 rifampicin rifampicin VERB admet-163 107 29 strongly strongly ADV admet-163 107 30 decreased decrease VERB admet-163 107 31 the the DET admet-163 107 32 expression expression NOUN admet-163 107 33 of of ADP admet-163 107 34 mate1 mate1 NOUN admet-163 107 35 and and CCONJ admet-163 107 36 mate2 mate2 NOUN admet-163 107 37 transporters transporter NOUN admet-163 107 38 in in ADP admet-163 107 39 human human ADJ admet-163 107 40 skin skin NOUN admet-163 107 41 ( ( PUNCT admet-163 107 42 figure figure NOUN admet-163 107 43 3a 3a NUM admet-163 107 44 ; ; PUNCT admet-163 107 45 top top ADJ admet-163 107 46 ) ) PUNCT admet-163 107 47 . . PUNCT admet-163 108 1 indeed indeed ADV admet-163 108 2 , , PUNCT admet-163 108 3 rifampicin rifampicin VERB admet-163 108 4 triggers trigger VERB admet-163 108 5 a a DET admet-163 108 6 44 44 NUM admet-163 108 7 % % NOUN admet-163 108 8 decrease decrease NOUN admet-163 108 9 in in ADP admet-163 108 10 mate1 mate1 NOUN admet-163 108 11 expression expression NOUN admet-163 108 12 ( ( PUNCT admet-163 108 13 p p X admet-163 108 14 < < X admet-163 108 15 0.05 0.05 NUM admet-163 108 16 ) ) PUNCT admet-163 108 17 and and CCONJ admet-163 108 18 a a DET admet-163 108 19 30 30 NUM admet-163 108 20 % % NOUN admet-163 108 21 decrease decrease NOUN admet-163 108 22 in in ADP admet-163 108 23 mate2 mate2 NOUN admet-163 108 24 expression expression NOUN admet-163 108 25 . . PUNCT admet-163 109 1 however however ADV admet-163 109 2 , , PUNCT admet-163 109 3 treatment treatment NOUN admet-163 109 4 of of ADP admet-163 109 5 skin skin NOUN admet-163 109 6 samples sample NOUN admet-163 109 7 with with ADP admet-163 109 8 rifampicin rifampicin VERB admet-163 109 9 had have VERB admet-163 109 10 no no DET admet-163 109 11 effect effect NOUN admet-163 109 12 on on ADP admet-163 109 13 the the DET admet-163 109 14 expression expression NOUN admet-163 109 15 level level NOUN admet-163 109 16 of of ADP admet-163 109 17 oatpb oatpb NOUN admet-163 109 18 , , PUNCT admet-163 109 19 oatpd oatpd ADJ admet-163 109 20 and and CCONJ admet-163 109 21 oatpe oatpe PROPN admet-163 109 22 ( ( PUNCT admet-163 109 23 data datum NOUN admet-163 109 24 not not PART admet-163 109 25 shown show VERB admet-163 109 26 ) ) PUNCT admet-163 109 27 . . PUNCT admet-163 110 1 the the DET admet-163 110 2 same same ADJ admet-163 110 3 experiment experiment NOUN admet-163 110 4 was be AUX admet-163 110 5 performed perform VERB admet-163 110 6 with with ADP admet-163 110 7 fresh fresh ADJ admet-163 110 8 human human ADJ admet-163 110 9 hepatocytes hepatocyte NOUN admet-163 110 10 in in ADP admet-163 110 11 primary primary ADJ admet-163 110 12 culture culture NOUN admet-163 110 13 treated treat VERB admet-163 110 14 with with ADP admet-163 110 15 rifampicin rifampicin VERB admet-163 110 16 20 20 NUM admet-163 110 17 µm µm NOUN admet-163 110 18 for for ADP admet-163 110 19 72 72 NUM admet-163 110 20 hours hour NOUN admet-163 110 21 . . PUNCT admet-163 111 1 the the DET admet-163 111 2 results result NOUN admet-163 111 3 presented present VERB admet-163 111 4 in in ADP admet-163 111 5 figure figure NOUN admet-163 111 6 3b 3b PROPN admet-163 111 7 bottom bottom NOUN admet-163 111 8 , , PUNCT admet-163 111 9 show show VERB admet-163 111 10 that that SCONJ admet-163 111 11 the the DET admet-163 111 12 expression expression NOUN admet-163 111 13 level level NOUN admet-163 111 14 of of ADP admet-163 111 15 mate1 mate1 NOUN admet-163 111 16 in in ADP admet-163 111 17 human human ADJ admet-163 111 18 hepatocytes hepatocyte NOUN admet-163 111 19 decreased decrease VERB admet-163 111 20 by by ADP admet-163 111 21 48 48 NUM admet-163 111 22 % % NOUN admet-163 111 23 after after ADP admet-163 111 24 being be AUX admet-163 111 25 treated treat VERB admet-163 111 26 with with ADP admet-163 111 27 rifampicin rifampicin VERB admet-163 111 28 ( ( PUNCT admet-163 111 29 data datum NOUN admet-163 111 30 performed perform VERB admet-163 111 31 in in ADP admet-163 111 32 triplicate triplicate NOUN admet-163 111 33 on on ADP admet-163 111 34 one one NUM admet-163 111 35 single single ADJ admet-163 111 36 donor donor NOUN admet-163 111 37 ) ) PUNCT admet-163 111 38 . . PUNCT admet-163 112 1 overall overall ADV admet-163 112 2 , , PUNCT admet-163 112 3 it it PRON admet-163 112 4 means mean VERB admet-163 112 5 that that SCONJ admet-163 112 6 the the DET admet-163 112 7 expression expression NOUN admet-163 112 8 of of ADP admet-163 112 9 mate1 mate1 NOUN admet-163 112 10 and and CCONJ admet-163 112 11 mate2 mate2 NOUN admet-163 112 12 transporters transporter NOUN admet-163 112 13 in in ADP admet-163 112 14 human human ADJ admet-163 112 15 skin skin NOUN admet-163 112 16 is be AUX admet-163 112 17 regulated regulate VERB admet-163 112 18 by by ADP admet-163 112 19 rifampicin rifampicin VERB admet-163 112 20 and and CCONJ admet-163 112 21 that that SCONJ admet-163 112 22 the the DET admet-163 112 23 same same ADJ admet-163 112 24 phenomenon phenomenon NOUN admet-163 112 25 occurs occur VERB admet-163 112 26 in in ADP admet-163 112 27 fresh fresh ADJ admet-163 112 28 human human ADJ admet-163 112 29 hepatocytes hepatocyte NOUN admet-163 112 30 with with ADP admet-163 112 31 mate1 mate1 PROPN admet-163 112 32 . . PUNCT admet-163 113 1 a a DET admet-163 113 2 : : PUNCT admet-163 113 3 human human ADJ admet-163 113 4 skin skin NOUN admet-163 113 5 b b NOUN admet-163 113 6 : : PUNCT admet-163 113 7 human human ADJ admet-163 113 8 hepatocytes hepatocyte NOUN admet-163 113 9 figure figure VERB admet-163 113 10 3 3 NUM admet-163 113 11 . . PUNCT admet-163 113 12 effect effect NOUN admet-163 113 13 of of ADP admet-163 113 14 rifampicin rifampicin VERB admet-163 113 15 on on ADP admet-163 113 16 gene gene NOUN admet-163 113 17 expression expression NOUN admet-163 113 18 of of ADP admet-163 113 19 slc47a1 slc47a1 NOUN admet-163 113 20 ( ( PUNCT admet-163 113 21 mate1 mate1 NOUN admet-163 113 22 ) ) PUNCT admet-163 113 23 and and CCONJ admet-163 113 24 slc47a2 slc47a2 ADV admet-163 113 25 ( ( PUNCT admet-163 113 26 mate2 mate2 NOUN admet-163 113 27 ) ) PUNCT admet-163 113 28 in in ADP admet-163 113 29 human human ADJ admet-163 113 30 skin skin NOUN admet-163 113 31 ( ( PUNCT admet-163 113 32 a a NOUN admet-163 113 33 ) ) PUNCT admet-163 113 34 and and CCONJ admet-163 113 35 human human ADJ admet-163 113 36 hepatocytes hepatocyte NOUN admet-163 113 37 ( ( PUNCT admet-163 113 38 b b NOUN admet-163 113 39 ) ) PUNCT admet-163 113 40 . . PUNCT admet-163 114 1 human human ADJ admet-163 114 2 skin skin NOUN admet-163 114 3 biopsies biopsy NOUN admet-163 114 4 in in ADP admet-163 114 5 organ organ NOUN admet-163 114 6 - - PUNCT admet-163 114 7 culture culture NOUN admet-163 114 8 ( ( PUNCT admet-163 114 9 three three NUM admet-163 114 10 donors donor NOUN admet-163 114 11 ) ) PUNCT admet-163 114 12 and and CCONJ admet-163 114 13 human human ADJ admet-163 114 14 hepatocytes hepatocyte NOUN admet-163 114 15 in in ADP admet-163 114 16 primary primary ADJ admet-163 114 17 culture culture NOUN admet-163 114 18 ( ( PUNCT admet-163 114 19 one one NUM admet-163 114 20 donor donor NOUN admet-163 114 21 ) ) PUNCT admet-163 114 22 were be AUX admet-163 114 23 treated treat VERB admet-163 114 24 with with ADP admet-163 114 25 rifampicin rifampicin VERB admet-163 114 26 ( ( PUNCT admet-163 114 27 20 20 NUM admet-163 114 28 µm µm NOUN admet-163 114 29 ) ) PUNCT admet-163 114 30 during during ADP admet-163 114 31 72 72 NUM admet-163 114 32 hours hour NOUN admet-163 114 33 . . PUNCT admet-163 115 1 expression expression NOUN admet-163 115 2 of of ADP admet-163 115 3 slc47a1 slc47a1 NOUN admet-163 115 4 and and CCONJ admet-163 115 5 slc47a2 slc47a2 PROPN admet-163 115 6 was be AUX admet-163 115 7 analysed analyse VERB admet-163 115 8 by by ADP admet-163 115 9 quantitative quantitative ADJ admet-163 115 10 real real ADJ admet-163 115 11 - - PUNCT admet-163 115 12 time time NOUN admet-163 115 13 reverse reverse ADJ admet-163 115 14 transcription transcription NOUN admet-163 115 15 - - PUNCT admet-163 115 16 pcr pcr NOUN admet-163 115 17 . . PUNCT admet-163 116 1 expression expression NOUN admet-163 116 2 of of ADP admet-163 116 3 mrna mrna PROPN admet-163 116 4 was be AUX admet-163 116 5 normalized normalize VERB admet-163 116 6 to to PART admet-163 116 7 gapdh gapdh VERB admet-163 116 8 . . PUNCT admet-163 117 1 all all DET admet-163 117 2 analyses analysis NOUN admet-163 117 3 were be AUX admet-163 117 4 performed perform VERB admet-163 117 5 in in ADP admet-163 117 6 triplicate triplicate NOUN admet-163 117 7 . . PUNCT admet-163 118 1 data datum NOUN admet-163 118 2 are be AUX admet-163 118 3 mean mean ADJ admet-163 118 4 and and CCONJ admet-163 118 5 sd sd NOUN admet-163 118 6 of of ADP admet-163 118 7 three three NUM admet-163 118 8 donors donor NOUN admet-163 118 9 ( ( PUNCT admet-163 118 10 human human ADJ admet-163 118 11 skin skin NOUN admet-163 118 12 ) ) PUNCT admet-163 118 13 . . PUNCT admet-163 119 1 all all DET admet-163 119 2 measures measure NOUN admet-163 119 3 were be AUX admet-163 119 4 done do VERB admet-163 119 5 in in ADP admet-163 119 6 triplicate triplicate NOUN admet-163 119 7 . . PUNCT admet-163 120 1 * * PUNCT admet-163 120 2 statistically statistically ADV admet-163 120 3 significant significant ADJ admet-163 120 4 ( ( PUNCT admet-163 120 5 p p X admet-163 120 6 < < X admet-163 120 7 0.05 0.05 NUM admet-163 120 8 ) ) PUNCT admet-163 120 9 . . PUNCT admet-163 121 1 rifampicin rifampicin PROPN admet-163 121 2 regulates regulate VERB admet-163 121 3 ahr ahr PROPN admet-163 121 4 and and CCONJ admet-163 121 5 rxra rxra NOUN admet-163 121 6 expression expression NOUN admet-163 121 7 in in ADP admet-163 121 8 human human ADJ admet-163 121 9 skin skin NOUN admet-163 121 10 it it PRON admet-163 121 11 has have AUX admet-163 121 12 been be AUX admet-163 121 13 shown show VERB admet-163 121 14 that that SCONJ admet-163 121 15 the the DET admet-163 121 16 expression expression NOUN admet-163 121 17 of of ADP admet-163 121 18 abc abc PROPN admet-163 121 19 transporter transporter VERB admet-163 121 20 mdr1 mdr1 PROPN admet-163 121 21 and and CCONJ admet-163 121 22 mrp2 mrp2 PROPN admet-163 121 23 is be AUX admet-163 121 24 induced induce VERB admet-163 121 25 by by ADP admet-163 121 26 rifampicin rifampicin VERB admet-163 121 27 via via ADP admet-163 121 28 pxr pxr NUM admet-163 121 29 and and CCONJ admet-163 121 30 car car NOUN admet-163 121 31 nuclear nuclear ADJ admet-163 121 32 receptors receptor NOUN admet-163 121 33 [ [ X admet-163 121 34 25 25 NUM admet-163 121 35 ] ] PUNCT admet-163 121 36 . . PUNCT admet-163 122 1 as as ADP admet-163 122 2 a a DET admet-163 122 3 consequence consequence NOUN admet-163 122 4 , , PUNCT admet-163 122 5 we we PRON admet-163 122 6 investigated investigate VERB admet-163 122 7 the the DET admet-163 122 8 involvement involvement NOUN admet-163 122 9 of of ADP admet-163 122 10 nuclear nuclear ADJ admet-163 122 11 receptors receptor NOUN admet-163 122 12 such such ADJ admet-163 122 13 as as ADP admet-163 122 14 pxr pxr PROPN admet-163 122 15 , , PUNCT admet-163 122 16 car car NOUN admet-163 122 17 , , PUNCT admet-163 122 18 ahr ahr PROPN admet-163 122 19 and and CCONJ admet-163 122 20 rxrα rxrα VERB admet-163 122 21 in in ADP admet-163 122 22 regulation regulation NOUN admet-163 122 23 of of ADP admet-163 122 24 slc slc PROPN admet-163 122 25 transporters transporter NOUN admet-163 122 26 by by ADP admet-163 122 27 rifampicin rifampicin VERB admet-163 122 28 . . PUNCT admet-163 123 1 the the DET admet-163 123 2 expression expression NOUN admet-163 123 3 admet admet PROPN admet-163 123 4 & & CCONJ admet-163 123 5 dmpk dmpk PROPN admet-163 123 6 3(1 3(1 NUM admet-163 123 7 ) ) PUNCT admet-163 123 8 ( ( PUNCT admet-163 123 9 2015 2015 NUM admet-163 123 10 ) ) PUNCT admet-163 123 11 34 34 NUM admet-163 123 12 - - SYM admet-163 123 13 44 44 NUM admet-163 123 14 expression expression NOUN admet-163 123 15 of of ADP admet-163 123 16 slc slc PROPN admet-163 123 17 transporters transporter NOUN admet-163 123 18 in in ADP admet-163 123 19 human human ADJ admet-163 123 20 skin skin NOUN admet-163 123 21 doi doi NOUN admet-163 123 22 : : PUNCT admet-163 123 23 10.5599 10.5599 NUM admet-163 123 24 / / SYM admet-163 123 25 admet.3.1.163 admet.3.1.163 NUM admet-163 123 26 41 41 NUM admet-163 123 27 of of ADP admet-163 123 28 these these DET admet-163 123 29 nuclear nuclear ADJ admet-163 123 30 receptors receptor NOUN admet-163 123 31 was be AUX admet-163 123 32 measured measure VERB admet-163 123 33 by by ADP admet-163 123 34 real real ADJ admet-163 123 35 time time NOUN admet-163 123 36 pcr pcr PROPN admet-163 123 37 in in ADP admet-163 123 38 skin skin NOUN admet-163 123 39 samples sample NOUN admet-163 123 40 treated treat VERB admet-163 123 41 with with ADP admet-163 123 42 20 20 NUM admet-163 123 43 µm µm NOUN admet-163 123 44 rifampicin rifampicin VERB admet-163 123 45 for for ADP admet-163 123 46 72 72 NUM admet-163 123 47 hours hour NOUN admet-163 123 48 and and CCONJ admet-163 123 49 compared compare VERB admet-163 123 50 to to PART admet-163 123 51 control control VERB admet-163 123 52 untreated untreated ADJ admet-163 123 53 skin skin NOUN admet-163 123 54 samples sample NOUN admet-163 123 55 . . PUNCT admet-163 124 1 the the DET admet-163 124 2 constitutive constitutive ADJ admet-163 124 3 expression expression NOUN admet-163 124 4 of of ADP admet-163 124 5 the the DET admet-163 124 6 four four NUM admet-163 124 7 nuclear nuclear ADJ admet-163 124 8 receptors receptor NOUN admet-163 124 9 in in ADP admet-163 124 10 human human ADJ admet-163 124 11 skin skin NOUN admet-163 124 12 , , PUNCT admet-163 124 13 hepatocytes hepatocyte NOUN admet-163 124 14 and and CCONJ admet-163 124 15 kidney kidney NOUN admet-163 124 16 ( ( PUNCT admet-163 124 17 figure figure NOUN admet-163 124 18 4a 4a NUM admet-163 124 19 , , PUNCT admet-163 124 20 top top ADJ admet-163 124 21 ) ) PUNCT admet-163 124 22 shows show VERB admet-163 124 23 that that SCONJ admet-163 124 24 unlike unlike ADP admet-163 124 25 in in ADP admet-163 124 26 hepatocytes hepatocyte NOUN admet-163 124 27 , , PUNCT admet-163 124 28 the the DET admet-163 124 29 expression expression NOUN admet-163 124 30 of of ADP admet-163 124 31 car car NOUN admet-163 124 32 and and CCONJ admet-163 124 33 pxr pxr NOUN admet-163 124 34 was be AUX admet-163 124 35 not not PART admet-163 124 36 detected detect VERB admet-163 124 37 in in ADP admet-163 124 38 human human ADJ admet-163 124 39 skin skin NOUN admet-163 124 40 ( ( PUNCT admet-163 124 41 ct ct NOUN admet-163 124 42 above above ADP admet-163 124 43 35 35 NUM admet-163 124 44 ) ) PUNCT admet-163 124 45 and and CCONJ admet-163 124 46 very very ADV admet-163 124 47 low low ADJ admet-163 124 48 in in ADP admet-163 124 49 kidney kidney NOUN admet-163 124 50 . . PUNCT admet-163 125 1 however however ADV admet-163 125 2 , , PUNCT admet-163 125 3 the the DET admet-163 125 4 expression expression NOUN admet-163 125 5 of of ADP admet-163 125 6 ahr ahr PROPN admet-163 125 7 and and CCONJ admet-163 125 8 rxrα rxrα NOUN admet-163 125 9 was be AUX admet-163 125 10 detected detect VERB admet-163 125 11 in in ADP admet-163 125 12 human human ADJ admet-163 125 13 skin skin NOUN admet-163 125 14 but but CCONJ admet-163 125 15 at at ADP admet-163 125 16 lower low ADJ admet-163 125 17 levels level NOUN admet-163 125 18 compared compare VERB admet-163 125 19 to to ADP admet-163 125 20 hepatocytes hepatocytes PROPN admet-163 125 21 and and CCONJ admet-163 125 22 kidney kidney NOUN admet-163 125 23 . . PUNCT admet-163 126 1 moreover moreover ADV admet-163 126 2 , , PUNCT admet-163 126 3 expression expression NOUN admet-163 126 4 of of ADP admet-163 126 5 ahr ahr PROPN admet-163 126 6 and and CCONJ admet-163 126 7 rxrα rxrα VERB admet-163 126 8 in in ADP admet-163 126 9 human human ADJ admet-163 126 10 skin skin NOUN admet-163 126 11 was be AUX admet-163 126 12 down down ADV admet-163 126 13 regulated regulate VERB admet-163 126 14 by by ADP admet-163 126 15 rifampicin rifampicin VERB admet-163 126 16 , , PUNCT admet-163 126 17 just just ADV admet-163 126 18 like like ADP admet-163 126 19 mate1 mate1 NOUN admet-163 126 20 and and CCONJ admet-163 126 21 mate2 mate2 NOUN admet-163 126 22 transporters transporter NOUN admet-163 126 23 ( ( PUNCT admet-163 126 24 figure figure NOUN admet-163 126 25 4b 4b NOUN admet-163 126 26 ; ; PUNCT admet-163 126 27 bottom bottom NOUN admet-163 126 28 ) ) PUNCT admet-163 126 29 . . PUNCT admet-163 127 1 indeed indeed ADV admet-163 127 2 , , PUNCT admet-163 127 3 the the DET admet-163 127 4 expression expression NOUN admet-163 127 5 of of ADP admet-163 127 6 ahr ahr PROPN admet-163 127 7 and and CCONJ admet-163 127 8 rxrα rxrα NOUN admet-163 127 9 decreased decrease VERB admet-163 127 10 by by ADP admet-163 127 11 32 32 NUM admet-163 127 12 % % NOUN admet-163 127 13 and and CCONJ admet-163 127 14 33 33 NUM admet-163 127 15 % % NOUN admet-163 127 16 when when SCONJ admet-163 127 17 skin skin NOUN admet-163 127 18 biopsies biopsy NOUN admet-163 127 19 were be AUX admet-163 127 20 treated treat VERB admet-163 127 21 with with ADP admet-163 127 22 rifampicin rifampicin VERB admet-163 127 23 compared compare VERB admet-163 127 24 to to ADP admet-163 127 25 untreated untreated ADJ admet-163 127 26 controls control NOUN admet-163 127 27 . . PUNCT admet-163 128 1 this this PRON admet-163 128 2 indicates indicate VERB admet-163 128 3 that that SCONJ admet-163 128 4 ahr ahr PROPN admet-163 128 5 and and CCONJ admet-163 128 6 rxrα rxrα NOUN admet-163 128 7 could could AUX admet-163 128 8 be be AUX admet-163 128 9 involved involve VERB admet-163 128 10 in in ADP admet-163 128 11 mate1 mate1 NOUN admet-163 128 12 and and CCONJ admet-163 128 13 mate2 mate2 NOUN admet-163 128 14 down down ADP admet-163 128 15 regulation regulation NOUN admet-163 128 16 by by ADP admet-163 128 17 rifampicin rifampicin VERB admet-163 128 18 . . PUNCT admet-163 129 1 a a DET admet-163 129 2 : : PUNCT admet-163 129 3 constitutive constitutive ADJ admet-163 129 4 expression expression NOUN admet-163 129 5 of of ADP admet-163 129 6 nuclear nuclear ADJ admet-163 129 7 receptors receptor NOUN admet-163 129 8 b b NOUN admet-163 129 9 : : PUNCT admet-163 129 10 effect effect NOUN admet-163 129 11 of of ADP admet-163 129 12 rifampicin rifampicin VERB admet-163 129 13 on on ADP admet-163 129 14 nuclear nuclear ADJ admet-163 129 15 receptors receptor NOUN admet-163 129 16 figure figure VERB admet-163 129 17 4 4 NUM admet-163 129 18 . . NOUN admet-163 130 1 constitutive constitutive ADJ admet-163 130 2 expression expression NOUN admet-163 130 3 of of ADP admet-163 130 4 nuclear nuclear ADJ admet-163 130 5 receptor receptor NOUN admet-163 130 6 in in ADP admet-163 130 7 human human ADJ admet-163 130 8 hepatocytes hepatocyte NOUN admet-163 130 9 , , PUNCT admet-163 130 10 human human ADJ admet-163 130 11 kidney kidney NOUN admet-163 130 12 , , PUNCT admet-163 130 13 and and CCONJ admet-163 130 14 human human ADJ admet-163 130 15 skin skin NOUN admet-163 130 16 ( ( PUNCT admet-163 130 17 a a NOUN admet-163 130 18 ) ) PUNCT admet-163 130 19 , , PUNCT admet-163 130 20 and and CCONJ admet-163 130 21 effect effect NOUN admet-163 130 22 of of ADP admet-163 130 23 rifampicin rifampicin VERB admet-163 130 24 on on ADP admet-163 130 25 the the DET admet-163 130 26 expression expression NOUN admet-163 130 27 of of ADP admet-163 130 28 rxrα rxrα NOUN admet-163 130 29 and and CCONJ admet-163 130 30 ahr ahr PROPN admet-163 130 31 in in ADP admet-163 130 32 human human ADJ admet-163 130 33 skin skin NOUN admet-163 130 34 . . PUNCT admet-163 131 1 ( ( PUNCT admet-163 131 2 a a X admet-163 131 3 ) ) PUNCT admet-163 131 4 results result NOUN admet-163 131 5 are be AUX admet-163 131 6 means mean NOUN admet-163 131 7 and and CCONJ admet-163 131 8 standard standard ADJ admet-163 131 9 error error NOUN admet-163 131 10 of of ADP admet-163 131 11 2 2 NUM admet-163 131 12 individual individual ADJ admet-163 131 13 skin skin NOUN admet-163 131 14 samples sample NOUN admet-163 131 15 from from ADP admet-163 131 16 2 2 NUM admet-163 131 17 different different ADJ admet-163 131 18 donors donor NOUN admet-163 131 19 , , PUNCT admet-163 131 20 one one NUM admet-163 131 21 hepatocyte hepatocyte NOUN admet-163 131 22 pool pool NOUN admet-163 131 23 of of ADP admet-163 131 24 26 26 NUM admet-163 131 25 donors donor NOUN admet-163 131 26 , , PUNCT admet-163 131 27 or or CCONJ admet-163 131 28 2 2 NUM admet-163 131 29 kidney kidney NOUN admet-163 131 30 mrna mrna VERB admet-163 131 31 from from ADP admet-163 131 32 2 2 NUM admet-163 131 33 donors donor NOUN admet-163 131 34 . . PUNCT admet-163 132 1 ( ( PUNCT admet-163 132 2 b b X admet-163 132 3 ) ) PUNCT admet-163 132 4 results result NOUN admet-163 132 5 from from ADP admet-163 132 6 one one NUM admet-163 132 7 single single ADJ admet-163 132 8 donor donor NOUN admet-163 132 9 . . PUNCT admet-163 133 1 all all DET admet-163 133 2 measures measure NOUN admet-163 133 3 were be AUX admet-163 133 4 done do VERB admet-163 133 5 in in ADP admet-163 133 6 triplicate triplicate NOUN admet-163 133 7 . . PUNCT admet-163 134 1 effect effect NOUN admet-163 134 2 of of ADP admet-163 134 3 sunlight sunlight NOUN admet-163 134 4 simulator simulator NOUN admet-163 134 5 on on ADP admet-163 134 6 the the DET admet-163 134 7 expression expression NOUN admet-163 134 8 of of ADP admet-163 134 9 slc slc PROPN admet-163 134 10 transporters transporter NOUN admet-163 134 11 in in ADP admet-163 134 12 human human ADJ admet-163 134 13 skin skin NOUN admet-163 134 14 the the DET admet-163 134 15 effect effect NOUN admet-163 134 16 of of ADP admet-163 134 17 exposure exposure NOUN admet-163 134 18 to to ADP admet-163 134 19 uv uv NOUN admet-163 134 20 light light NOUN admet-163 134 21 on on ADP admet-163 134 22 the the DET admet-163 134 23 expression expression NOUN admet-163 134 24 of of ADP admet-163 134 25 slc slc PROPN admet-163 134 26 transporters transporter NOUN admet-163 134 27 was be AUX admet-163 134 28 investigated investigate VERB admet-163 134 29 in in ADP admet-163 134 30 two two NUM admet-163 134 31 different different ADJ admet-163 134 32 donors donor NOUN admet-163 134 33 . . PUNCT admet-163 135 1 human human ADJ admet-163 135 2 skin skin NOUN admet-163 135 3 biopsies biopsy NOUN admet-163 135 4 were be AUX admet-163 135 5 maintained maintain VERB admet-163 135 6 in in ADP admet-163 135 7 organ organ NOUN admet-163 135 8 - - PUNCT admet-163 135 9 culture culture NOUN admet-163 135 10 for for ADP admet-163 135 11 three three NUM admet-163 135 12 days day NOUN admet-163 135 13 as as SCONJ admet-163 135 14 explained explain VERB admet-163 135 15 in in ADP admet-163 135 16 the the DET admet-163 135 17 experimental experimental ADJ admet-163 135 18 section section NOUN admet-163 135 19 and and CCONJ admet-163 135 20 exposed expose VERB admet-163 135 21 to to ADP admet-163 135 22 uv uv NOUN admet-163 135 23 light light NOUN admet-163 135 24 for for ADP admet-163 135 25 1 1 NUM admet-163 135 26 hour hour NOUN admet-163 135 27 every every DET admet-163 135 28 24 24 NUM admet-163 135 29 hours hour NOUN admet-163 135 30 using use VERB admet-163 135 31 a a DET admet-163 135 32 solar solar ADJ admet-163 135 33 simulator simulator NOUN admet-163 135 34 . . PUNCT admet-163 136 1 control control PROPN admet-163 136 2 alriquet alriquet PROPN admet-163 136 3 m m PROPN admet-163 136 4 admet admet PROPN admet-163 136 5 & & CCONJ admet-163 136 6 dmpk dmpk PROPN admet-163 136 7 3(1 3(1 NUM admet-163 136 8 ) ) PUNCT admet-163 136 9 ( ( PUNCT admet-163 136 10 2015 2015 NUM admet-163 136 11 ) ) PUNCT admet-163 136 12 34 34 NUM admet-163 136 13 - - SYM admet-163 136 14 44 44 NUM admet-163 136 15 42 42 NUM admet-163 136 16 samples sample NOUN admet-163 136 17 were be AUX admet-163 136 18 not not PART admet-163 136 19 exposed expose VERB admet-163 136 20 to to ADP admet-163 136 21 uv uv NOUN admet-163 136 22 lights light NOUN admet-163 136 23 . . PUNCT admet-163 137 1 the the DET admet-163 137 2 expression expression NOUN admet-163 137 3 of of ADP admet-163 137 4 the the DET admet-163 137 5 slc slc PROPN admet-163 137 6 transporters transporter NOUN admet-163 137 7 found find VERB admet-163 137 8 to to PART admet-163 137 9 be be AUX admet-163 137 10 expressed express VERB admet-163 137 11 in in ADP admet-163 137 12 human human ADJ admet-163 137 13 skin skin NOUN admet-163 137 14 was be AUX admet-163 137 15 measured measure VERB admet-163 137 16 by by ADP admet-163 137 17 real real ADJ admet-163 137 18 time time NOUN admet-163 137 19 pcr pcr PROPN admet-163 137 20 . . PUNCT admet-163 138 1 the the DET admet-163 138 2 results result NOUN admet-163 138 3 presented present VERB admet-163 138 4 in in ADP admet-163 138 5 figure figure NOUN admet-163 138 6 5 5 NUM admet-163 138 7 show show VERB admet-163 138 8 that that SCONJ admet-163 138 9 following follow VERB admet-163 138 10 the the DET admet-163 138 11 exposure exposure NOUN admet-163 138 12 of of ADP admet-163 138 13 skin skin NOUN admet-163 138 14 biopsies biopsy NOUN admet-163 138 15 to to ADP admet-163 138 16 uv uv NOUN admet-163 138 17 light light NOUN admet-163 138 18 , , PUNCT admet-163 138 19 the the DET admet-163 138 20 expression expression NOUN admet-163 138 21 level level NOUN admet-163 138 22 of of ADP admet-163 138 23 mate1 mate1 NOUN admet-163 138 24 and and CCONJ admet-163 138 25 mate2 mate2 NOUN admet-163 138 26 decreased decrease VERB admet-163 138 27 by by ADP admet-163 138 28 43 43 NUM admet-163 138 29 % % NOUN admet-163 138 30 ( ( PUNCT admet-163 138 31 p p X admet-163 138 32 < < X admet-163 138 33 0.05 0.05 NUM admet-163 138 34 ) ) PUNCT admet-163 138 35 and and CCONJ admet-163 138 36 60 60 NUM admet-163 138 37 % % NOUN admet-163 138 38 , , PUNCT admet-163 138 39 respectively respectively ADV admet-163 138 40 . . PUNCT admet-163 139 1 the the DET admet-163 139 2 expression expression NOUN admet-163 139 3 of of ADP admet-163 139 4 slco3a1 slco3a1 NOUN admet-163 139 5 and and CCONJ admet-163 139 6 slco4a1 slco4a1 VERB admet-163 139 7 was be AUX admet-163 139 8 not not PART admet-163 139 9 modified modify VERB admet-163 139 10 by by ADP admet-163 139 11 exposure exposure NOUN admet-163 139 12 of of ADP admet-163 139 13 skin skin NOUN admet-163 139 14 biopsies biopsy NOUN admet-163 139 15 to to ADP admet-163 139 16 uv uv NOUN admet-163 139 17 light light NOUN admet-163 139 18 ( ( PUNCT admet-163 139 19 data datum NOUN admet-163 139 20 not not PART admet-163 139 21 shown show VERB admet-163 139 22 ) ) PUNCT admet-163 139 23 . . PUNCT admet-163 140 1 figure5 figure5 NOUN admet-163 140 2 . . PUNCT admet-163 141 1 effect effect NOUN admet-163 141 2 of of ADP admet-163 141 3 uv uv NOUN admet-163 141 4 light light ADJ admet-163 141 5 exposure exposure NOUN admet-163 141 6 on on ADP admet-163 141 7 the the DET admet-163 141 8 expression expression NOUN admet-163 141 9 of of ADP admet-163 141 10 slc47a1 slc47a1 NOUN admet-163 141 11 and and CCONJ admet-163 141 12 slc47a2 slc47a2 ADV admet-163 141 13 in in ADP admet-163 141 14 human human ADJ admet-163 141 15 skin skin NOUN admet-163 141 16 . . PUNCT admet-163 142 1 results result NOUN admet-163 142 2 are be AUX admet-163 142 3 means mean NOUN admet-163 142 4 and and CCONJ admet-163 142 5 standard standard ADJ admet-163 142 6 error error NOUN admet-163 142 7 of of ADP admet-163 142 8 2 2 NUM admet-163 142 9 individual individual ADJ admet-163 142 10 skin skin NOUN admet-163 142 11 samples sample NOUN admet-163 142 12 from from ADP admet-163 142 13 2 2 NUM admet-163 142 14 different different ADJ admet-163 142 15 donors donor NOUN admet-163 142 16 . . PUNCT admet-163 143 1 all all DET admet-163 143 2 measures measure NOUN admet-163 143 3 were be AUX admet-163 143 4 done do VERB admet-163 143 5 in in ADP admet-163 143 6 triplicate triplicate NOUN admet-163 143 7 . . PUNCT admet-163 144 1 * * PUNCT admet-163 144 2 statistically statistically ADV admet-163 144 3 significant significant ADJ admet-163 144 4 ( ( PUNCT admet-163 144 5 p p X admet-163 144 6 < < X admet-163 144 7 0.05 0.05 NUM admet-163 144 8 ) ) PUNCT admet-163 144 9 . . PUNCT admet-163 145 1 discussion discussion NOUN admet-163 145 2 transporters transporter NOUN admet-163 145 3 are be AUX admet-163 145 4 recognized recognize VERB admet-163 145 5 as as ADP admet-163 145 6 important important ADJ admet-163 145 7 actors actor NOUN admet-163 145 8 of of ADP admet-163 145 9 drug drug NOUN admet-163 145 10 absorption absorption NOUN admet-163 145 11 , , PUNCT admet-163 145 12 distribution distribution NOUN admet-163 145 13 and and CCONJ admet-163 145 14 excretion excretion NOUN admet-163 145 15 . . PUNCT admet-163 146 1 it it PRON admet-163 146 2 has have AUX admet-163 146 3 also also ADV admet-163 146 4 been be AUX admet-163 146 5 demonstrated demonstrate VERB admet-163 146 6 that that SCONJ admet-163 146 7 they they PRON admet-163 146 8 are be AUX admet-163 146 9 involved involve VERB admet-163 146 10 in in ADP admet-163 146 11 drug drug NOUN admet-163 146 12 - - PUNCT admet-163 146 13 drug drug NOUN admet-163 146 14 interactions interaction NOUN admet-163 146 15 , , PUNCT admet-163 146 16 turning turn VERB admet-163 146 17 them they PRON admet-163 146 18 into into ADP admet-163 146 19 elements element NOUN admet-163 146 20 to to PART admet-163 146 21 be be AUX admet-163 146 22 studied study VERB admet-163 146 23 in in ADP admet-163 146 24 drug drug NOUN admet-163 146 25 development development NOUN admet-163 146 26 . . PUNCT admet-163 147 1 abc abc PROPN admet-163 147 2 and and CCONJ admet-163 147 3 slc slc PROPN admet-163 147 4 transporters transporter NOUN admet-163 147 5 have have AUX admet-163 147 6 been be AUX admet-163 147 7 well well ADV admet-163 147 8 studied study VERB admet-163 147 9 in in ADP admet-163 147 10 liver liver NOUN admet-163 147 11 and and CCONJ admet-163 147 12 kidney kidney NOUN admet-163 147 13 which which PRON admet-163 147 14 are be AUX admet-163 147 15 responsible responsible ADJ admet-163 147 16 for for ADP admet-163 147 17 most most ADJ admet-163 147 18 drug drug NOUN admet-163 147 19 excretion excretion NOUN admet-163 147 20 . . PUNCT admet-163 148 1 however however ADV admet-163 148 2 , , PUNCT admet-163 148 3 their their PRON admet-163 148 4 expression expression NOUN admet-163 148 5 and and CCONJ admet-163 148 6 role role NOUN admet-163 148 7 in in ADP admet-163 148 8 human human ADJ admet-163 148 9 skin skin NOUN admet-163 148 10 are be AUX admet-163 148 11 poorly poorly ADV admet-163 148 12 understood understand VERB admet-163 148 13 . . PUNCT admet-163 149 1 in in ADP admet-163 149 2 the the DET admet-163 149 3 present present ADJ admet-163 149 4 study study NOUN admet-163 149 5 , , PUNCT admet-163 149 6 we we PRON admet-163 149 7 have have AUX admet-163 149 8 observed observe VERB admet-163 149 9 the the DET admet-163 149 10 expression expression NOUN admet-163 149 11 of of ADP admet-163 149 12 oatpb oatpb PROPN admet-163 149 13 , , PUNCT admet-163 149 14 oatpd oatpd ADJ admet-163 149 15 , , PUNCT admet-163 149 16 oatpe oatpe NOUN admet-163 149 17 , , PUNCT admet-163 149 18 mate1 mate1 NOUN admet-163 149 19 and and CCONJ admet-163 149 20 mate2 mate2 NOUN admet-163 149 21 transporters transporter NOUN admet-163 149 22 in in ADP admet-163 149 23 human human ADJ admet-163 149 24 skin skin NOUN admet-163 149 25 : : PUNCT admet-163 149 26 oatpe oatpe NOUN admet-163 149 27 and and CCONJ admet-163 149 28 mate1 mate1 NOUN admet-163 149 29 transporters transporter NOUN admet-163 149 30 being be AUX admet-163 149 31 the the DET admet-163 149 32 most most ADV admet-163 149 33 highly highly ADV admet-163 149 34 expressed express VERB admet-163 149 35 . . PUNCT admet-163 150 1 a a DET admet-163 150 2 recent recent ADJ admet-163 150 3 study study NOUN admet-163 150 4 has have AUX admet-163 150 5 shown show VERB admet-163 150 6 that that SCONJ admet-163 150 7 slc slc PROPN admet-163 150 8 transporters transporter NOUN admet-163 150 9 were be AUX admet-163 150 10 expressed express VERB admet-163 150 11 in in ADP admet-163 150 12 the the DET admet-163 150 13 human human ADJ admet-163 150 14 skin skin NOUN admet-163 150 15 to to ADP admet-163 150 16 a a DET admet-163 150 17 moderate moderate ADJ admet-163 150 18 and and CCONJ admet-163 150 19 variable variable ADJ admet-163 150 20 extent extent NOUN admet-163 150 21 , , PUNCT admet-163 150 22 but but CCONJ admet-163 150 23 mate mate NOUN admet-163 150 24 transporter transporter NOUN admet-163 150 25 expression expression NOUN admet-163 150 26 was be AUX admet-163 150 27 not not PART admet-163 150 28 investigated investigate VERB admet-163 150 29 [ [ X admet-163 150 30 19 19 NUM admet-163 150 31 ] ] PUNCT admet-163 150 32 . . PUNCT admet-163 151 1 to to ADP admet-163 151 2 our our PRON admet-163 151 3 knowledge knowledge NOUN admet-163 151 4 it it PRON admet-163 151 5 is be AUX admet-163 151 6 first first ADJ admet-163 151 7 time time NOUN admet-163 151 8 that that SCONJ admet-163 151 9 there there PRON admet-163 151 10 is be VERB admet-163 151 11 evidence evidence NOUN admet-163 151 12 for for ADP admet-163 151 13 the the DET admet-163 151 14 expression expression NOUN admet-163 151 15 of of ADP admet-163 151 16 mate mate NOUN admet-163 151 17 transporter transporter NOUN admet-163 151 18 in in ADP admet-163 151 19 human human ADJ admet-163 151 20 skin skin NOUN admet-163 151 21 . . PUNCT admet-163 152 1 mate mate NOUN admet-163 152 2 transporters transporter NOUN admet-163 152 3 are be AUX admet-163 152 4 found find VERB admet-163 152 5 in in ADP admet-163 152 6 many many ADJ admet-163 152 7 living live VERB admet-163 152 8 organisms organism NOUN admet-163 152 9 and and CCONJ admet-163 152 10 are be AUX admet-163 152 11 involved involve VERB admet-163 152 12 in in ADP admet-163 152 13 multidrug multidrug NOUN admet-163 152 14 resistance resistance NOUN admet-163 152 15 . . PUNCT admet-163 153 1 in in ADP admet-163 153 2 human human NOUN admet-163 153 3 , , PUNCT admet-163 153 4 mate1 mate1 PROPN admet-163 153 5 is be AUX admet-163 153 6 expressed express VERB admet-163 153 7 in in ADP admet-163 153 8 both both CCONJ admet-163 153 9 liver liver NOUN admet-163 153 10 and and CCONJ admet-163 153 11 kidney kidney NOUN admet-163 153 12 while while SCONJ admet-163 153 13 mate2 mate2 NOUN admet-163 153 14 is be AUX admet-163 153 15 kidney kidney NOUN admet-163 153 16 - - PUNCT admet-163 153 17 specific specific NOUN admet-163 153 18 [ [ X admet-163 153 19 26 26 NUM admet-163 153 20 ] ] PUNCT admet-163 153 21 . . PUNCT admet-163 154 1 those those DET admet-163 154 2 transporters transporter NOUN admet-163 154 3 play play VERB admet-163 154 4 a a DET admet-163 154 5 role role NOUN admet-163 154 6 in in ADP admet-163 154 7 renal renal ADJ admet-163 154 8 and and CCONJ admet-163 154 9 biliary biliary ADJ admet-163 154 10 excretion excretion NOUN admet-163 154 11 of of ADP admet-163 154 12 endogenous endogenous ADJ admet-163 154 13 and and CCONJ admet-163 154 14 exogenous exogenous ADJ admet-163 154 15 compounds compound NOUN admet-163 154 16 including include VERB admet-163 154 17 xenobiotics xenobiotic NOUN admet-163 154 18 and and CCONJ admet-163 154 19 drugs drug NOUN admet-163 154 20 [ [ X admet-163 154 21 26,27 26,27 NUM admet-163 154 22 ] ] PUNCT admet-163 154 23 . . PUNCT admet-163 155 1 although although SCONJ admet-163 155 2 mate1 mate1 NOUN admet-163 155 3 transporter transporter NOUN admet-163 155 4 belongs belong VERB admet-163 155 5 to to ADP admet-163 155 6 slc slc PROPN admet-163 155 7 family family PROPN admet-163 155 8 , , PUNCT admet-163 155 9 it it PRON admet-163 155 10 is be AUX admet-163 155 11 an an DET admet-163 155 12 efflux efflux NOUN admet-163 155 13 transporter transporter NOUN admet-163 155 14 and and CCONJ admet-163 155 15 its its PRON admet-163 155 16 activity activity NOUN admet-163 155 17 depends depend VERB admet-163 155 18 on on ADP admet-163 155 19 physiological physiological ADJ admet-163 155 20 ph ph NOUN admet-163 155 21 . . PUNCT admet-163 155 22 mate1 mate1 PROPN admet-163 155 23 is be AUX admet-163 155 24 thought think VERB admet-163 155 25 to to PART admet-163 155 26 be be AUX admet-163 155 27 responsible responsible ADJ admet-163 155 28 for for ADP admet-163 155 29 the the DET admet-163 155 30 last last ADJ admet-163 155 31 step step NOUN admet-163 155 32 of of ADP admet-163 155 33 excretion excretion NOUN admet-163 155 34 of of ADP admet-163 155 35 organic organic ADJ admet-163 155 36 cations cation NOUN admet-163 155 37 involving involve VERB admet-163 155 38 proton proton NOUN admet-163 155 39 exchange exchange NOUN admet-163 155 40 [ [ X admet-163 155 41 27 27 NUM admet-163 155 42 ] ] PUNCT admet-163 155 43 . . PUNCT admet-163 156 1 by by ADP admet-163 156 2 showing show VERB admet-163 156 3 that that PRON admet-163 156 4 mate1 mate1 NOUN admet-163 156 5 is be AUX admet-163 156 6 strongly strongly ADV admet-163 156 7 expressed express VERB admet-163 156 8 in in ADP admet-163 156 9 human human ADJ admet-163 156 10 skin skin NOUN admet-163 156 11 , , PUNCT admet-163 156 12 these these DET admet-163 156 13 data datum NOUN admet-163 156 14 show show VERB admet-163 156 15 its its PRON admet-163 156 16 possible possible ADJ admet-163 156 17 involvement involvement NOUN admet-163 156 18 in in ADP admet-163 156 19 absorption absorption NOUN admet-163 156 20 , , PUNCT admet-163 156 21 distribution distribution NOUN admet-163 156 22 and and CCONJ admet-163 156 23 excretion excretion NOUN admet-163 156 24 of of ADP admet-163 156 25 topically topically ADV admet-163 156 26 applied apply VERB admet-163 156 27 drugs drug NOUN admet-163 156 28 . . PUNCT admet-163 157 1 moreover moreover ADV admet-163 157 2 , , PUNCT admet-163 157 3 this this DET admet-163 157 4 transporter transporter NOUN admet-163 157 5 is be AUX admet-163 157 6 down down ADV admet-163 157 7 regulated regulate VERB admet-163 157 8 by by ADP admet-163 157 9 rifampicin rifampicin VERB admet-163 157 10 which which PRON admet-163 157 11 suggests suggest VERB admet-163 157 12 that that SCONJ admet-163 157 13 it it PRON admet-163 157 14 might might AUX admet-163 157 15 play play VERB admet-163 157 16 a a DET admet-163 157 17 role role NOUN admet-163 157 18 in in ADP admet-163 157 19 drug drug NOUN admet-163 157 20 - - PUNCT admet-163 157 21 drug drug NOUN admet-163 157 22 interactions interaction NOUN admet-163 157 23 . . PUNCT admet-163 158 1 further further ADJ admet-163 158 2 investigations investigation NOUN admet-163 158 3 are be AUX admet-163 158 4 needed need VERB admet-163 158 5 to to PART admet-163 158 6 characterize characterize VERB admet-163 158 7 the the DET admet-163 158 8 functional functional ADJ admet-163 158 9 role role NOUN admet-163 158 10 of of ADP admet-163 158 11 mate mate NOUN admet-163 158 12 transporters transporter NOUN admet-163 158 13 in in ADP admet-163 158 14 human human ADJ admet-163 158 15 skin skin NOUN admet-163 158 16 . . PUNCT admet-163 159 1 admet admet PROPN admet-163 159 2 & & CCONJ admet-163 159 3 dmpk dmpk PROPN admet-163 159 4 3(1 3(1 NUM admet-163 159 5 ) ) PUNCT admet-163 159 6 ( ( PUNCT admet-163 159 7 2015 2015 NUM admet-163 159 8 ) ) PUNCT admet-163 159 9 34 34 NUM admet-163 159 10 - - SYM admet-163 159 11 44 44 NUM admet-163 159 12 expression expression NOUN admet-163 159 13 of of ADP admet-163 159 14 slc slc PROPN admet-163 159 15 transporters transporter NOUN admet-163 159 16 in in ADP admet-163 159 17 human human ADJ admet-163 159 18 skin skin NOUN admet-163 159 19 doi doi NOUN admet-163 159 20 : : PUNCT admet-163 159 21 10.5599 10.5599 NUM admet-163 159 22 / / SYM admet-163 159 23 admet.3.1.163 admet.3.1.163 NUM admet-163 159 24 43 43 NUM admet-163 159 25 furthermore furthermore ADV admet-163 159 26 , , PUNCT admet-163 159 27 oatpe oatpe NOUN admet-163 159 28 is be AUX admet-163 159 29 poorly poorly ADV admet-163 159 30 known know VERB admet-163 159 31 but but CCONJ admet-163 159 32 is be AUX admet-163 159 33 highly highly ADV admet-163 159 34 expressed express VERB admet-163 159 35 in in ADP admet-163 159 36 human human ADJ admet-163 159 37 skin skin NOUN admet-163 159 38 . . PUNCT admet-163 160 1 it it PRON admet-163 160 2 would would AUX admet-163 160 3 be be AUX admet-163 160 4 very very ADV admet-163 160 5 interesting interesting ADJ admet-163 160 6 to to PART admet-163 160 7 better well ADV admet-163 160 8 characterize characterize VERB admet-163 160 9 this this DET admet-163 160 10 transporter transporter NOUN admet-163 160 11 and and CCONJ admet-163 160 12 to to PART admet-163 160 13 investigate investigate VERB admet-163 160 14 its its PRON admet-163 160 15 role role NOUN admet-163 160 16 in in ADP admet-163 160 17 drug drug NOUN admet-163 160 18 disposition disposition NOUN admet-163 160 19 and and CCONJ admet-163 160 20 to to PART admet-163 160 21 understand understand VERB admet-163 160 22 its its PRON admet-163 160 23 function function NOUN admet-163 160 24 . . PUNCT admet-163 161 1 the the DET admet-163 161 2 results result NOUN admet-163 161 3 presented present VERB admet-163 161 4 in in ADP admet-163 161 5 this this DET admet-163 161 6 work work NOUN admet-163 161 7 showed show VERB admet-163 161 8 that that SCONJ admet-163 161 9 some some DET admet-163 161 10 slc slc PROPN admet-163 161 11 transporters transporter NOUN admet-163 161 12 have have VERB admet-163 161 13 a a DET admet-163 161 14 specific specific ADJ admet-163 161 15 expression expression NOUN admet-163 161 16 profile profile NOUN admet-163 161 17 in in ADP admet-163 161 18 human human ADJ admet-163 161 19 skin skin NOUN admet-163 161 20 . . PUNCT admet-163 162 1 mate1 mate1 NOUN admet-163 162 2 transporter transporter NOUN admet-163 162 3 is be AUX admet-163 162 4 highly highly ADV admet-163 162 5 expressed express VERB admet-163 162 6 in in ADP admet-163 162 7 human human ADJ admet-163 162 8 skin skin NOUN admet-163 162 9 compared compare VERB admet-163 162 10 to to ADP admet-163 162 11 other other ADJ admet-163 162 12 slc slc PROPN admet-163 162 13 transporters transporter NOUN admet-163 162 14 , , PUNCT admet-163 162 15 suggesting suggest VERB admet-163 162 16 that that SCONJ admet-163 162 17 mate1 mate1 NOUN admet-163 162 18 may may AUX admet-163 162 19 play play VERB admet-163 162 20 a a DET admet-163 162 21 role role NOUN admet-163 162 22 in in ADP admet-163 162 23 topical topical ADJ admet-163 162 24 drug drug NOUN admet-163 162 25 exposure exposure NOUN admet-163 162 26 and and CCONJ admet-163 162 27 drug drug NOUN admet-163 162 28 - - PUNCT admet-163 162 29 drug drug NOUN admet-163 162 30 interactions interaction NOUN admet-163 162 31 . . PUNCT admet-163 163 1 the the DET admet-163 163 2 extensive extensive ADJ admet-163 163 3 expression expression NOUN admet-163 163 4 of of ADP admet-163 163 5 mate1 mate1 NOUN admet-163 163 6 transporter transporter NOUN admet-163 163 7 in in ADP admet-163 163 8 human human ADJ admet-163 163 9 skin skin NOUN admet-163 163 10 and and CCONJ admet-163 163 11 the the DET admet-163 163 12 down down ADJ admet-163 163 13 - - PUNCT admet-163 163 14 regulation regulation NOUN admet-163 163 15 by by ADP admet-163 163 16 solar solar ADJ admet-163 163 17 simulator simulator NOUN admet-163 163 18 exposure exposure NOUN admet-163 163 19 suggest suggest VERB admet-163 163 20 that that SCONJ admet-163 163 21 this this DET admet-163 163 22 transporter transporter NOUN admet-163 163 23 might might AUX admet-163 163 24 serve serve VERB admet-163 163 25 as as ADP admet-163 163 26 a a DET admet-163 163 27 biomarker biomarker NOUN admet-163 163 28 for for ADP admet-163 163 29 skin skin NOUN admet-163 163 30 cancers cancer NOUN admet-163 163 31 , , PUNCT admet-163 163 32 particularly particularly ADV admet-163 163 33 those those PRON admet-163 163 34 induced induce VERB admet-163 163 35 by by ADP admet-163 163 36 solar solar ADJ admet-163 163 37 exposure exposure NOUN admet-163 163 38 . . PUNCT admet-163 164 1 furthermore furthermore ADV admet-163 164 2 , , PUNCT admet-163 164 3 the the DET admet-163 164 4 expression expression NOUN admet-163 164 5 of of ADP admet-163 164 6 mate1 mate1 NOUN admet-163 164 7 transporter transporter NOUN admet-163 164 8 in in ADP admet-163 164 9 human human ADJ admet-163 164 10 skin skin NOUN admet-163 164 11 may may AUX admet-163 164 12 play play VERB admet-163 164 13 an an DET admet-163 164 14 important important ADJ admet-163 164 15 role role NOUN admet-163 164 16 in in ADP admet-163 164 17 chemosensitivity chemosensitivity NOUN admet-163 164 18 of of ADP admet-163 164 19 cutaneous cutaneous ADJ admet-163 164 20 cancer cancer NOUN admet-163 164 21 cells cell NOUN admet-163 164 22 and and CCONJ admet-163 164 23 thus thus ADV admet-163 164 24 may may AUX admet-163 164 25 be be AUX admet-163 164 26 the the DET admet-163 164 27 basis basis NOUN admet-163 164 28 for for ADP admet-163 164 29 the the DET admet-163 164 30 discovery discovery NOUN admet-163 164 31 of of ADP admet-163 164 32 novel novel ADJ admet-163 164 33 agents agent NOUN admet-163 164 34 for for ADP admet-163 164 35 the the DET admet-163 164 36 treatment treatment NOUN admet-163 164 37 of of ADP admet-163 164 38 skin skin NOUN admet-163 164 39 cancers cancer NOUN admet-163 164 40 [ [ X admet-163 164 41 28 28 NUM admet-163 164 42 ] ] PUNCT admet-163 164 43 . . PUNCT admet-163 165 1 conclusions conclusion NOUN admet-163 165 2 our our PRON admet-163 165 3 present present ADJ admet-163 165 4 findings finding NOUN admet-163 165 5 suggest suggest VERB admet-163 165 6 that that SCONJ admet-163 165 7 oatpe oatpe NOUN admet-163 165 8 and and CCONJ admet-163 165 9 mate1 mate1 NOUN admet-163 165 10 transporters transporter NOUN admet-163 165 11 are be AUX admet-163 165 12 highly highly ADV admet-163 165 13 expressed express VERB admet-163 165 14 in in ADP admet-163 165 15 human human ADJ admet-163 165 16 skin skin NOUN admet-163 165 17 and and CCONJ admet-163 165 18 that that DET admet-163 165 19 mate1 mate1 NOUN admet-163 165 20 is be AUX admet-163 165 21 down down ADV admet-163 165 22 - - PUNCT admet-163 165 23 regulated regulate VERB admet-163 165 24 by by ADP admet-163 165 25 exposure exposure NOUN admet-163 165 26 to to ADP admet-163 165 27 uv uv NOUN admet-163 165 28 light light NOUN admet-163 165 29 , , PUNCT admet-163 165 30 but but CCONJ admet-163 165 31 investigations investigation NOUN admet-163 165 32 are be AUX admet-163 165 33 needed need VERB admet-163 165 34 to to PART admet-163 165 35 identify identify VERB admet-163 165 36 the the DET admet-163 165 37 potential potential ADJ admet-163 165 38 role role NOUN admet-163 165 39 of of ADP admet-163 165 40 oatpe oatpe NOUN admet-163 165 41 and and CCONJ admet-163 165 42 mate1 mate1 NOUN admet-163 165 43 transporters transporter NOUN admet-163 165 44 in in ADP admet-163 165 45 the the DET admet-163 165 46 skin skin NOUN admet-163 165 47 disposition disposition NOUN admet-163 165 48 of of ADP admet-163 165 49 topically topically ADV admet-163 165 50 applied apply VERB admet-163 165 51 drugs drug NOUN admet-163 165 52 . . PUNCT admet-163 166 1 references reference NOUN admet-163 166 2 [ [ X admet-163 166 3 1 1 NUM admet-163 166 4 ] ] PUNCT admet-163 166 5 p.m. p.m. NOUN admet-163 166 6 elias elias PROPN admet-163 166 7 , , PUNCT admet-163 166 8 current current ADJ admet-163 166 9 allergy allergy NOUN admet-163 166 10 asthma asthma PROPN admet-163 166 11 reports report NOUN admet-163 166 12 , , PUNCT admet-163 166 13 8 8 NUM admet-163 166 14 ( ( PUNCT admet-163 166 15 2008 2008 NUM admet-163 166 16 ) ) PUNCT admet-163 166 17 299 299 NUM admet-163 166 18 - - SYM admet-163 166 19 305 305 NUM admet-163 166 20 . . PUNCT admet-163 167 1 [ [ X admet-163 167 2 2 2 NUM admet-163 167 3 ] ] X admet-163 167 4 j.m j.m PROPN admet-163 167 5 . . PROPN admet-163 167 6 baron baron PROPN admet-163 167 7 , , PUNCT admet-163 167 8 d. d. PROPN admet-163 167 9 holler holler PROPN admet-163 167 10 , , PUNCT admet-163 167 11 r. r. PROPN admet-163 167 12 schiffer schiffer PROPN admet-163 167 13 , , PUNCT admet-163 167 14 s. s. PROPN admet-163 167 15 frankenberg frankenberg PROPN admet-163 167 16 , , PUNCT admet-163 167 17 m. m. NOUN admet-163 167 18 neis neis PROPN admet-163 167 19 , , PUNCT admet-163 167 20 h.f h.f PROPN admet-163 167 21 . . PROPN admet-163 167 22 merck merck PROPN admet-163 167 23 , , PUNCT admet-163 167 24 f.k f.k PROPN admet-163 167 25 . . PROPN admet-163 167 26 jugert jugert PROPN admet-163 167 27 , , PUNCT admet-163 167 28 journal journal NOUN admet-163 167 29 of of ADP admet-163 167 30 investigative investigative ADJ admet-163 167 31 dermatology dermatology NOUN admet-163 167 32 , , PUNCT admet-163 167 33 116 116 NUM admet-163 167 34 ( ( PUNCT admet-163 167 35 2001 2001 NUM admet-163 167 36 ) ) PUNCT admet-163 167 37 541 541 NUM admet-163 167 38 - - SYM admet-163 167 39 548 548 NUM admet-163 167 40 . . PUNCT admet-163 168 1 [ [ X admet-163 168 2 3 3 X admet-163 168 3 ] ] PUNCT admet-163 168 4 r. r. PROPN admet-163 168 5 schiffer schiffer PROPN admet-163 168 6 , , PUNCT admet-163 168 7 m. m. NOUN admet-163 168 8 neis neis PROPN admet-163 168 9 , , PUNCT admet-163 168 10 d. d. PROPN admet-163 168 11 höller höller PROPN admet-163 168 12 , , PUNCT admet-163 168 13 f. f. PROPN admet-163 168 14 rodriguez rodriguez PROPN admet-163 168 15 , , PUNCT admet-163 168 16 a. a. NOUN admet-163 168 17 geier geier NOUN admet-163 168 18 , , PUNCT admet-163 168 19 c. c. PROPN admet-163 168 20 gartung gartung PROPN admet-163 168 21 , , PUNCT admet-163 168 22 f. f. PROPN admet-163 168 23 lammert lammert PROPN admet-163 168 24 , , PUNCT admet-163 168 25 a. a. PROPN admet-163 168 26 dreuw dreuw PROPN admet-163 168 27 , , PUNCT admet-163 168 28 g. g. PROPN admet-163 168 29 zwadloklarwasser zwadloklarwasser PROPN admet-163 168 30 , , PUNCT admet-163 168 31 h. h. PROPN admet-163 168 32 merck merck PROPN admet-163 168 33 , , PUNCT admet-163 168 34 f. f. PROPN admet-163 168 35 jugert jugert PROPN admet-163 168 36 , , PUNCT admet-163 168 37 j.m j.m PROPN admet-163 168 38 . . PROPN admet-163 168 39 baron baron PROPN admet-163 168 40 journal journal NOUN admet-163 168 41 of of ADP admet-163 168 42 investigative investigative ADJ admet-163 168 43 dermatology dermatology NOUN admet-163 168 44 , , PUNCT admet-163 168 45 120 120 NUM admet-163 168 46 ( ( PUNCT admet-163 168 47 2003 2003 NUM admet-163 168 48 ) ) PUNCT admet-163 168 49 285291 285291 NUM admet-163 168 50 . . PUNCT admet-163 169 1 [ [ X admet-163 169 2 4 4 X admet-163 169 3 ] ] PUNCT admet-163 169 4 h. h. PROPN admet-163 169 5 schaeffer schaeffer PROPN admet-163 169 6 , , PUNCT admet-163 169 7 t. t. NOUN admet-163 169 8 redelmeier redelmeier NOUN admet-163 169 9 , , PUNCT admet-163 169 10 skin skin NOUN admet-163 169 11 barrier barrier NOUN admet-163 169 12 : : PUNCT admet-163 169 13 principles principle NOUN admet-163 169 14 of of ADP admet-163 169 15 percutaneous percutaneous ADJ admet-163 169 16 absorption absorption NOUN admet-163 169 17 , , PUNCT admet-163 169 18 s. s. PROPN admet-163 169 19 karger karger PROPN admet-163 169 20 , , PUNCT admet-163 169 21 basel basel PROPN admet-163 169 22 , , PUNCT admet-163 169 23 ch ch NOUN admet-163 169 24 , , PUNCT admet-163 169 25 1996 1996 NUM admet-163 169 26 . . PUNCT admet-163 170 1 [ [ X admet-163 170 2 5 5 X admet-163 170 3 ] ] PUNCT admet-163 170 4 h. h. PROPN admet-163 170 5 swanson swanson PROPN admet-163 170 6 , , PUNCT admet-163 170 7 chemico chemico NOUN admet-163 170 8 - - ADJ admet-163 170 9 biological biological ADJ admet-163 170 10 interactions interaction NOUN admet-163 170 11 , , PUNCT admet-163 170 12 149 149 NUM admet-163 170 13 , , PUNCT admet-163 170 14 ( ( PUNCT admet-163 170 15 2004 2004 NUM admet-163 170 16 ) ) PUNCT admet-163 170 17 69 69 NUM admet-163 170 18 - - SYM admet-163 170 19 79 79 NUM admet-163 170 20 . . PUNCT admet-163 171 1 [ [ X admet-163 171 2 6 6 NUM admet-163 171 3 ] ] PUNCT admet-163 171 4 a. a. NOUN admet-163 171 5 williams williams PROPN admet-163 171 6 , , PUNCT admet-163 171 7 transdermal transdermal ADJ admet-163 171 8 and and CCONJ admet-163 171 9 topical topical ADJ admet-163 171 10 drug drug NOUN admet-163 171 11 delivery delivery NOUN admet-163 171 12 , , PUNCT admet-163 171 13 pharmaceutical pharmaceutical NOUN admet-163 171 14 press press NOUN admet-163 171 15 , , PUNCT admet-163 171 16 london london PROPN admet-163 171 17 , , PUNCT admet-163 171 18 2003 2003 NUM admet-163 171 19 . . PUNCT admet-163 172 1 [ [ X admet-163 172 2 7 7 X admet-163 172 3 ] ] PUNCT admet-163 172 4 m. m. NOUN admet-163 172 5 pham pham PROPN admet-163 172 6 , , PUNCT admet-163 172 7 j. j. PROPN admet-163 172 8 magdalou magdalou PROPN admet-163 172 9 , , PUNCT admet-163 172 10 m. m. PROPN admet-163 172 11 totis totis PROPN admet-163 172 12 , , PUNCT admet-163 172 13 s. s. PROPN admet-163 172 14 fournel fournel PROPN admet-163 172 15 - - PUNCT admet-163 172 16 gigleux gigleux PROPN admet-163 172 17 , , PUNCT admet-163 172 18 g. g. PROPN admet-163 172 19 siest siest PROPN admet-163 172 20 , , PUNCT admet-163 172 21 b. b. PROPN admet-163 172 22 hammock hammock NOUN admet-163 172 23 , , PUNCT admet-163 172 24 biochemical biochemical ADJ admet-163 172 25 pharmacology pharmacology NOUN admet-163 172 26 , , PUNCT admet-163 172 27 38 38 NUM admet-163 172 28 ( ( PUNCT admet-163 172 29 1989 1989 NUM admet-163 172 30 ) ) PUNCT admet-163 172 31 2187 2187 NUM admet-163 172 32 - - SYM admet-163 172 33 2194 2194 NUM admet-163 172 34 . . PUNCT admet-163 173 1 [ [ X admet-163 173 2 8 8 NUM admet-163 173 3 ] ] PUNCT admet-163 173 4 k. k. PROPN admet-163 173 5 madison madison PROPN admet-163 173 6 , , PUNCT admet-163 173 7 journal journal NOUN admet-163 173 8 of of ADP admet-163 173 9 investigative investigative ADJ admet-163 173 10 dermatology dermatology NOUN admet-163 173 11 , , PUNCT admet-163 173 12 121 121 NUM admet-163 173 13 ( ( PUNCT admet-163 173 14 2003 2003 NUM admet-163 173 15 ) ) PUNCT admet-163 173 16 231 231 NUM admet-163 173 17 - - SYM admet-163 173 18 241 241 NUM admet-163 173 19 . . PUNCT admet-163 174 1 [ [ X admet-163 174 2 9 9 NUM admet-163 174 3 ] ] PUNCT admet-163 174 4 m. m. NOUN admet-163 174 5 prausnitz prausnitz NOUN admet-163 174 6 , , PUNCT admet-163 174 7 s. s. PROPN admet-163 174 8 mitragotri mitragotri PROPN admet-163 174 9 , , PUNCT admet-163 174 10 r. r. PROPN admet-163 174 11 langer langer PROPN admet-163 174 12 , , PUNCT admet-163 174 13 nature nature NOUN admet-163 174 14 reviews review VERB admet-163 174 15 drug drug NOUN admet-163 174 16 discovery discovery NOUN admet-163 174 17 , , PUNCT admet-163 174 18 3 3 NUM admet-163 174 19 ( ( PUNCT admet-163 174 20 2004 2004 NUM admet-163 174 21 ) ) PUNCT admet-163 174 22 115 115 NUM admet-163 174 23 - - SYM admet-163 174 24 124 124 NUM admet-163 174 25 . . PUNCT admet-163 175 1 [ [ X admet-163 175 2 10 10 NUM admet-163 175 3 ] ] X admet-163 175 4 m.a m.a PROPN admet-163 175 5 . . PROPN admet-163 175 6 sleeman sleeman PROPN admet-163 175 7 , , PUNCT admet-163 175 8 j.d j.d PROPN admet-163 175 9 . . PROPN admet-163 175 10 watson watson PROPN admet-163 175 11 , , PUNCT admet-163 175 12 j.g j.g PROPN admet-163 175 13 . . PROPN admet-163 175 14 murison murison PROPN admet-163 175 15 , , PUNCT admet-163 175 16 journal journal NOUN admet-163 175 17 of of ADP admet-163 175 18 investigative investigative ADJ admet-163 175 19 dermatology dermatology NOUN admet-163 175 20 , , PUNCT admet-163 175 21 115 115 NUM admet-163 175 22 ( ( PUNCT admet-163 175 23 2000 2000 NUM admet-163 175 24 ) ) PUNCT admet-163 175 25 19 19 NUM admet-163 175 26 - - SYM admet-163 175 27 23 23 NUM admet-163 175 28 . . PUNCT admet-163 176 1 [ [ X admet-163 176 2 11 11 NUM admet-163 176 3 ] ] PUNCT admet-163 176 4 a. a. NOUN admet-163 176 5 dreuw dreuw PROPN admet-163 176 6 , , PUNCT admet-163 176 7 h.m h.m PROPN admet-163 176 8 . . PROPN admet-163 176 9 hermanns hermanns PROPN admet-163 176 10 , , PUNCT admet-163 176 11 r. r. PROPN admet-163 176 12 heise heise PROPN admet-163 176 13 , , PUNCT admet-163 176 14 s. s. PROPN admet-163 176 15 joussen joussen PROPN admet-163 176 16 , , PUNCT admet-163 176 17 f. f. PROPN admet-163 176 18 rodriguez rodriguez PROPN admet-163 176 19 , , PUNCT admet-163 176 20 y. y. PROPN admet-163 176 21 marquardt marquardt PROPN admet-163 176 22 , , PUNCT admet-163 176 23 f. f. PROPN admet-163 176 24 jugert jugert PROPN admet-163 176 25 , , PUNCT admet-163 176 26 h.f h.f PROPN admet-163 176 27 . . PROPN admet-163 176 28 merck merck PROPN admet-163 176 29 , , PUNCT admet-163 176 30 p.c p.c PROPN admet-163 176 31 . . PROPN admet-163 176 32 hinrich hinrich PROPN admet-163 176 33 , , PUNCT admet-163 176 34 j.m j.m PROPN admet-163 176 35 . . PROPN admet-163 176 36 baron baron PROPN admet-163 176 37 , , PUNCT admet-163 176 38 journal journal NOUN admet-163 176 39 of of ADP admet-163 176 40 investigative investigative ADJ admet-163 176 41 dermatology dermatology NOUN admet-163 176 42 , , PUNCT admet-163 176 43 124 124 NUM admet-163 176 44 ( ( PUNCT admet-163 176 45 2005 2005 NUM admet-163 176 46 ) ) PUNCT admet-163 176 47 28 28 NUM admet-163 176 48 - - SYM admet-163 176 49 37 37 NUM admet-163 176 50 . . PUNCT admet-163 177 1 [ [ X admet-163 177 2 12 12 NUM admet-163 177 3 ] ] X admet-163 177 4 g.j g.j PROPN admet-163 177 5 . . PROPN admet-163 177 6 randolph randolph PROPN admet-163 177 7 , , PUNCT admet-163 177 8 s. s. PROPN admet-163 177 9 beaulieu beaulieu PROPN admet-163 177 10 , , PUNCT admet-163 177 11 m. m. NOUN admet-163 177 12 pope pope PROPN admet-163 177 13 , , PUNCT admet-163 177 14 i. i. PROPN admet-163 177 15 sugarawa sugarawa PROPN admet-163 177 16 , , PUNCT admet-163 177 17 l. l. PROPN admet-163 177 18 hoffman hoffman PROPN admet-163 177 19 , , PUNCT admet-163 177 20 r.m r.m PROPN admet-163 177 21 . . PROPN admet-163 177 22 steinman steinman PROPN admet-163 177 23 , , PUNCT admet-163 177 24 w.a w.a PROPN admet-163 177 25 . . PROPN admet-163 177 26 muller muller PROPN admet-163 177 27 , , PUNCT admet-163 177 28 proceedings proceeding NOUN admet-163 177 29 of of ADP admet-163 177 30 the the DET admet-163 177 31 national national PROPN admet-163 177 32 academy academy PROPN admet-163 177 33 of of ADP admet-163 177 34 sciences sciences PROPN admet-163 177 35 usa usa PROPN admet-163 177 36 , , PUNCT admet-163 177 37 95 95 NUM admet-163 177 38 ( ( PUNCT admet-163 177 39 1998 1998 NUM admet-163 177 40 ) ) PUNCT admet-163 177 41 6924 6924 NUM admet-163 177 42 - - SYM admet-163 177 43 6929 6929 NUM admet-163 177 44 . . PUNCT admet-163 178 1 [ [ X admet-163 178 2 13 13 NUM admet-163 178 3 ] ] PUNCT admet-163 178 4 r. r. PROPN admet-163 178 5 heise heise PROPN admet-163 178 6 , , PUNCT admet-163 178 7 c. c. PROPN admet-163 178 8 skazik skazik PROPN admet-163 178 9 , , PUNCT admet-163 178 10 f. f. PROPN admet-163 178 11 rodriguez rodriguez PROPN admet-163 178 12 , , PUNCT admet-163 178 13 s. s. PROPN admet-163 178 14 tanzel tanzel PROPN admet-163 178 15 , , PUNCT admet-163 178 16 y. y. PROPN admet-163 178 17 marquardt marquardt PROPN admet-163 178 18 , , PUNCT admet-163 178 19 s. s. PROPN admet-163 178 20 joussen joussen PROPN admet-163 178 21 , , PUNCT admet-163 178 22 a.f a.f PROPN admet-163 178 23 . . PROPN admet-163 178 24 wendel wendel PROPN admet-163 178 25 , , PUNCT admet-163 178 26 m. m. NOUN admet-163 178 27 wosnitza wosnitza PROPN admet-163 178 28 , , PUNCT admet-163 178 29 h.f h.f PROPN admet-163 178 30 . . PROPN admet-163 178 31 merck merck PROPN admet-163 178 32 , , PUNCT admet-163 178 33 j.m j.m PROPN admet-163 178 34 . . PROPN admet-163 178 35 baron baron PROPN admet-163 178 36 , , PUNCT admet-163 178 37 journal journal NOUN admet-163 178 38 of of ADP admet-163 178 39 investigative investigative ADJ admet-163 178 40 dermatology dermatology NOUN admet-163 178 41 , , PUNCT admet-163 178 42 130 130 NUM admet-163 178 43 ( ( PUNCT admet-163 178 44 2010 2010 NUM admet-163 178 45 ) ) PUNCT admet-163 178 46 305 305 NUM admet-163 178 47 - - SYM admet-163 178 48 308 308 NUM admet-163 178 49 . . PUNCT admet-163 179 1 [ [ X admet-163 179 2 14 14 NUM admet-163 179 3 ] ] X admet-163 179 4 m. m. NOUN admet-163 179 5 colone colone NOUN admet-163 179 6 , , PUNCT admet-163 179 7 a. a. NOUN admet-163 179 8 calcabrini calcabrini PROPN admet-163 179 9 , , PUNCT admet-163 179 10 l. l. PROPN admet-163 179 11 toccacieli toccacieli PROPN admet-163 179 12 , , PUNCT admet-163 179 13 g. g. PROPN admet-163 179 14 bozzuto bozzuto PROPN admet-163 179 15 , , PUNCT admet-163 179 16 a. a. NOUN admet-163 179 17 stringaro stringaro NOUN admet-163 179 18 , , PUNCT admet-163 179 19 m. m. NOUN admet-163 179 20 gentile gentile NOUN admet-163 179 21 , , PUNCT admet-163 179 22 m. m. NOUN admet-163 179 23 cianfriglia cianfriglia PROPN admet-163 179 24 , , PUNCT admet-163 179 25 a. a. NOUN admet-163 179 26 ciervo ciervo PROPN admet-163 179 27 , , PUNCT admet-163 179 28 m. m. NOUN admet-163 179 29 caraglia caraglia PROPN admet-163 179 30 , , PUNCT admet-163 179 31 a. a. PROPN admet-163 179 32 budillon budillon PROPN admet-163 179 33 , , PUNCT admet-163 179 34 g. g. PROPN admet-163 179 35 meo meo PROPN admet-163 179 36 , , PUNCT admet-163 179 37 g. g. PROPN admet-163 179 38 arancia arancia PROPN admet-163 179 39 , , PUNCT admet-163 179 40 a. a. PROPN admet-163 179 41 molinari molinari PROPN admet-163 179 42 , , PUNCT admet-163 179 43 journal journal NOUN admet-163 179 44 of of ADP admet-163 179 45 investigative investigative ADJ admet-163 179 46 dermatology dermatology NOUN admet-163 179 47 , , PUNCT admet-163 179 48 128 128 NUM admet-163 179 49 ( ( PUNCT admet-163 179 50 2008 2008 NUM admet-163 179 51 ) ) PUNCT admet-163 179 52 957 957 NUM admet-163 179 53 - - SYM admet-163 179 54 971 971 NUM admet-163 179 55 . . PUNCT admet-163 180 1 [ [ X admet-163 180 2 15 15 NUM admet-163 180 3 ] ] X admet-163 180 4 s. s. PROPN admet-163 180 5 heimerl heimerl PROPN admet-163 180 6 , , PUNCT admet-163 180 7 a.k a.k PROPN admet-163 180 8 . . PROPN admet-163 180 9 bosserhoff bosserhoff PROPN admet-163 180 10 , , PUNCT admet-163 180 11 t. t. PROPN admet-163 180 12 langmann langmann PROPN admet-163 180 13 , , PUNCT admet-163 180 14 j. j. PROPN admet-163 180 15 ecker ecker PROPN admet-163 180 16 , , PUNCT admet-163 180 17 g. g. PROPN admet-163 180 18 schmitz schmitz PROPN admet-163 180 19 , , PUNCT admet-163 180 20 melanoma melanoma PROPN admet-163 180 21 research research NOUN admet-163 180 22 , , PUNCT admet-163 180 23 17 17 NUM admet-163 180 24 ( ( PUNCT admet-163 180 25 2007 2007 NUM admet-163 180 26 ) ) PUNCT admet-163 180 27 265273 265273 NUM admet-163 180 28 . . PUNCT admet-163 181 1 [ [ X admet-163 181 2 16 16 NUM admet-163 181 3 ] ] X admet-163 181 4 s. s. PROPN admet-163 181 5 takenaka takenaka PROPN admet-163 181 6 , , PUNCT admet-163 181 7 t t PROPN admet-163 181 8 itoh itoh NOUN admet-163 181 9 , , PUNCT admet-163 181 10 r. r. PROPN admet-163 181 11 fujiwara fujiwara PROPN admet-163 181 12 , , PUNCT admet-163 181 13 pharmacology pharmacology NOUN admet-163 181 14 research research NOUN admet-163 181 15 & & CCONJ admet-163 181 16 perspectives perspective NOUN admet-163 181 17 1 1 NUM admet-163 181 18 ( ( PUNCT admet-163 181 19 2013 2013 NUM admet-163 181 20 ) ) PUNCT admet-163 181 21 1 1 NUM admet-163 181 22 - - SYM admet-163 181 23 8 8 NUM admet-163 181 24 . . PUNCT admet-163 182 1 alriquet alriquet PROPN admet-163 182 2 m m PROPN admet-163 182 3 admet admet PROPN admet-163 182 4 & & CCONJ admet-163 182 5 dmpk dmpk PROPN admet-163 182 6 3(1 3(1 NUM admet-163 182 7 ) ) PUNCT admet-163 182 8 ( ( PUNCT admet-163 182 9 2015 2015 NUM admet-163 182 10 ) ) PUNCT admet-163 182 11 34 34 NUM admet-163 182 12 - - SYM admet-163 182 13 44 44 NUM admet-163 182 14 44 44 NUM admet-163 182 15 [ [ X admet-163 182 16 17 17 NUM admet-163 182 17 ] ] X admet-163 182 18 h. h. PROPN admet-163 182 19 osman osman PROPN admet-163 182 20 - - PUNCT admet-163 182 21 ponchet ponchet PROPN admet-163 182 22 , , PUNCT admet-163 182 23 a. a. NOUN admet-163 182 24 boulai boulai PROPN admet-163 182 25 , , PUNCT admet-163 182 26 m. m. NOUN admet-163 182 27 kouidhi kouidhi PROPN admet-163 182 28 , , PUNCT admet-163 182 29 k. k. PROPN admet-163 182 30 sevin sevin PROPN admet-163 182 31 , , PUNCT admet-163 182 32 m. m. NOUN admet-163 182 33 alriquet alriquet PROPN admet-163 182 34 , , PUNCT admet-163 182 35 a. a. NOUN admet-163 182 36 gaborit gaborit PROPN admet-163 182 37 , , PUNCT admet-163 182 38 b. b. PROPN admet-163 182 39 bertino bertino PROPN admet-163 182 40 , , PUNCT admet-163 182 41 p. p. PROPN admet-163 182 42 comby comby PROPN admet-163 182 43 , , PUNCT admet-163 182 44 b. b. PROPN admet-163 182 45 ruty ruty PROPN admet-163 182 46 , , PUNCT admet-163 182 47 drug drug NOUN admet-163 182 48 metabolism metabolism NOUN admet-163 182 49 and and CCONJ admet-163 182 50 drug drug NOUN admet-163 182 51 interactions interaction NOUN admet-163 182 52 , , PUNCT admet-163 182 53 29 29 NUM admet-163 182 54 ( ( PUNCT admet-163 182 55 2014 2014 NUM admet-163 182 56 ) ) PUNCT admet-163 182 57 91 91 NUM admet-163 182 58 - - SYM admet-163 182 59 100 100 NUM admet-163 182 60 . . PUNCT admet-163 183 1 [ [ X admet-163 183 2 18 18 NUM admet-163 183 3 ] ] X admet-163 183 4 q. q. PROPN admet-163 183 5 li li PROPN admet-163 183 6 , , PUNCT admet-163 183 7 h. h. PROPN admet-163 183 8 tsuji tsuji PROPN admet-163 183 9 , , PUNCT admet-163 183 10 y. y. PROPN admet-163 183 11 kato kato PROPN admet-163 183 12 , , PUNCT admet-163 183 13 y. y. PROPN admet-163 183 14 sai sai PROPN admet-163 183 15 , , PUNCT admet-163 183 16 y. y. PROPN admet-163 183 17 kubo kubo PROPN admet-163 183 18 , , PUNCT admet-163 183 19 a. a. PROPN admet-163 183 20 tsuji tsuji PROPN admet-163 183 21 , , PUNCT admet-163 183 22 journal journal NOUN admet-163 183 23 of of ADP admet-163 183 24 controlled control VERB admet-163 183 25 release release NOUN admet-163 183 26 110 110 NUM admet-163 183 27 ( ( PUNCT admet-163 183 28 2006 2006 NUM admet-163 183 29 ) ) PUNCT admet-163 183 30 542 542 NUM admet-163 183 31 - - SYM admet-163 183 32 56 56 NUM admet-163 183 33 . . PUNCT admet-163 184 1 [ [ X admet-163 184 2 19 19 NUM admet-163 184 3 ] ] X admet-163 184 4 r. r. PROPN admet-163 184 5 fujiwara fujiwara PROPN admet-163 184 6 , , PUNCT admet-163 184 7 s. s. PROPN admet-163 184 8 takenada takenada PROPN admet-163 184 9 , , PUNCT admet-163 184 10 m. m. NOUN admet-163 184 11 hashimoto hashimoto NOUN admet-163 184 12 , , PUNCT admet-163 184 13 t. t. PROPN admet-163 184 14 narawa narawa PROPN admet-163 184 15 , , PUNCT admet-163 184 16 t t PROPN admet-163 184 17 , , PUNCT admet-163 184 18 itoh itoh ADJ admet-163 184 19 , , PUNCT admet-163 184 20 scientific scientific ADJ admet-163 184 21 reports report NOUN admet-163 184 22 , , PUNCT admet-163 184 23 4 4 NUM admet-163 184 24 ( ( PUNCT admet-163 184 25 2014 2014 NUM admet-163 184 26 ) ) PUNCT admet-163 184 27 1 1 NUM admet-163 184 28 - - SYM admet-163 184 29 8 8 NUM admet-163 184 30 . . PUNCT admet-163 185 1 [ [ X admet-163 185 2 20 20 NUM admet-163 185 3 ] ] X admet-163 185 4 european european PROPN admet-163 185 5 medicines medicine NOUN admet-163 185 6 agency agency NOUN admet-163 185 7 ( ( PUNCT admet-163 185 8 ema ema PROPN admet-163 185 9 ) ) PUNCT admet-163 185 10 , , PUNCT admet-163 185 11 2012 2012 NUM admet-163 185 12 , , PUNCT admet-163 185 13 guideline guideline NOUN admet-163 185 14 on on ADP admet-163 185 15 the the DET admet-163 185 16 investigation investigation NOUN admet-163 185 17 of of ADP admet-163 185 18 drug drug NOUN admet-163 185 19 interactions interaction NOUN admet-163 185 20 . . PUNCT admet-163 186 1 [ [ X admet-163 186 2 21 21 NUM admet-163 186 3 ] ] PUNCT admet-163 186 4 k. k. PROPN admet-163 186 5 maeda maeda PROPN admet-163 186 6 , , PUNCT admet-163 186 7 y. y. PROPN admet-163 186 8 sugiyama sugiyama PROPN admet-163 186 9 , , PUNCT admet-163 186 10 molecular molecular ADJ admet-163 186 11 aspects aspect NOUN admet-163 186 12 of of ADP admet-163 186 13 medicine medicine NOUN admet-163 186 14 34 34 NUM admet-163 186 15 ( ( PUNCT admet-163 186 16 2013 2013 NUM admet-163 186 17 ) ) PUNCT admet-163 186 18 711 711 NUM admet-163 186 19 - - SYM admet-163 186 20 718 718 NUM admet-163 186 21 . . PUNCT admet-163 187 1 [ [ X admet-163 187 2 22 22 NUM admet-163 187 3 ] ] PUNCT admet-163 187 4 us us PROPN admet-163 187 5 food food NOUN admet-163 187 6 and and CCONJ admet-163 187 7 drug drug PROPN admet-163 187 8 administration administration PROPN admet-163 187 9 ( ( PUNCT admet-163 187 10 fda fda PROPN admet-163 187 11 ) ) PUNCT admet-163 187 12 , , PUNCT admet-163 187 13 2012 2012 NUM admet-163 187 14 . . PUNCT admet-163 188 1 guidance guidance NOUN admet-163 188 2 for for ADP admet-163 188 3 industry industry NOUN admet-163 188 4 drug drug NOUN admet-163 188 5 interaction interaction NOUN admet-163 188 6 studies study NOUN admet-163 188 7 — — PUNCT admet-163 188 8 study study NOUN admet-163 188 9 design design NOUN admet-163 188 10 , , PUNCT admet-163 188 11 data datum NOUN admet-163 188 12 analysis analysis NOUN admet-163 188 13 , , PUNCT admet-163 188 14 implications implication NOUN admet-163 188 15 for for ADP admet-163 188 16 dosing dose VERB admet-163 188 17 , , PUNCT admet-163 188 18 and and CCONJ admet-163 188 19 labeling labeling NOUN admet-163 188 20 recommendations recommendation NOUN admet-163 188 21 . . PUNCT admet-163 189 1 [ [ X admet-163 189 2 23 23 NUM admet-163 189 3 ] ] SYM admet-163 189 4 f.g.m f.g.m NOUN admet-163 189 5 . . PUNCT admet-163 189 6 russel russel PROPN admet-163 189 7 , , PUNCT admet-163 189 8 in in ADP admet-163 189 9 enzyme enzyme NOUN admet-163 189 10 and and CCONJ admet-163 189 11 transporter transporter NOUN admet-163 189 12 - - PUNCT admet-163 189 13 based base VERB admet-163 189 14 drug drug NOUN admet-163 189 15 - - PUNCT admet-163 189 16 drug drug NOUN admet-163 189 17 interactions interaction NOUN admet-163 189 18 . . PUNCT admet-163 190 1 progress progress NOUN admet-163 190 2 and and CCONJ admet-163 190 3 future future ADJ admet-163 190 4 challenges challenge NOUN admet-163 190 5 , , PUNCT admet-163 190 6 k.s k.s PROPN admet-163 190 7 . . PROPN admet-163 190 8 pang pang PROPN admet-163 190 9 , , PUNCT admet-163 190 10 a.d a.d PROPN admet-163 190 11 . . PROPN admet-163 190 12 rodrigues rodrigues PROPN admet-163 190 13 , , PUNCT admet-163 190 14 r.m r.m PROPN admet-163 190 15 . . PROPN admet-163 190 16 peter peter PROPN admet-163 190 17 , , PUNCT admet-163 190 18 springer springer NOUN admet-163 190 19 , , PUNCT admet-163 190 20 2010 2010 NUM admet-163 190 21 , , PUNCT admet-163 190 22 p. p. NOUN admet-163 190 23 27 27 NUM admet-163 190 24 - - SYM admet-163 190 25 49 49 NUM admet-163 190 26 . . PUNCT admet-163 191 1 [ [ X admet-163 191 2 24 24 NUM admet-163 191 3 ] ] X admet-163 191 4 s. s. PROPN admet-163 191 5 haenisch haenisch PROPN admet-163 191 6 , , PUNCT admet-163 191 7 s. s. PROPN admet-163 191 8 laechelt laechelt PROPN admet-163 191 9 , , PUNCT admet-163 191 10 h. h. PROPN admet-163 191 11 bruckmueller bruckmueller NOUN admet-163 191 12 , , PUNCT admet-163 191 13 a. a. PROPN admet-163 191 14 werk werk PROPN admet-163 191 15 , , PUNCT admet-163 191 16 a. a. NOUN admet-163 191 17 noack noack PROPN admet-163 191 18 , , PUNCT admet-163 191 19 o. o. PROPN admet-163 191 20 bruhn bruhn NOUN admet-163 191 21 , , PUNCT admet-163 191 22 c. c. PROPN admet-163 191 23 remmler remmler NOUN admet-163 191 24 , , PUNCT admet-163 191 25 i. i. NOUN admet-163 191 26 cascorbi cascorbi PROPN admet-163 191 27 , , PUNCT admet-163 191 28 molecular molecular ADJ admet-163 191 29 pharmacology pharmacology NOUN admet-163 191 30 , , PUNCT admet-163 191 31 80 80 NUM admet-163 191 32 ( ( PUNCT admet-163 191 33 2011 2011 NUM admet-163 191 34 ) ) PUNCT admet-163 191 35 314 314 NUM admet-163 191 36 - - SYM admet-163 191 37 320 320 NUM admet-163 191 38 . . PUNCT admet-163 192 1 [ [ X admet-163 192 2 25 25 NUM admet-163 192 3 ] ] PUNCT admet-163 192 4 m. m. NOUN admet-163 192 5 sun sun PROPN admet-163 192 6 , , PUNCT admet-163 192 7 w. w. PROPN admet-163 192 8 cui cui PROPN admet-163 192 9 , , PUNCT admet-163 192 10 s.k s.k PROPN admet-163 192 11 . . PROPN admet-163 192 12 woody woody PROPN admet-163 192 13 , , PUNCT admet-163 192 14 j.l j.l PROPN admet-163 192 15 . . PROPN admet-163 192 16 staudinger stauding ADJ admet-163 192 17 , , PUNCT admet-163 192 18 drug drug NOUN admet-163 192 19 metabolism metabolism NOUN admet-163 192 20 and and CCONJ admet-163 192 21 disposition disposition NOUN admet-163 192 22 , , PUNCT admet-163 192 23 43 43 NUM admet-163 192 24 ( ( PUNCT admet-163 192 25 2015 2015 NUM admet-163 192 26 ) ) PUNCT admet-163 192 27 335 335 NUM admet-163 192 28 - - SYM admet-163 192 29 43 43 NUM admet-163 192 30 . . PUNCT admet-163 193 1 [ [ X admet-163 193 2 26 26 NUM admet-163 193 3 ] ] PUNCT admet-163 193 4 h. h. PROPN admet-163 193 5 omote omote PROPN admet-163 193 6 , , PUNCT admet-163 193 7 m. m. NOUN admet-163 193 8 hiasa hiasa NOUN admet-163 193 9 , , PUNCT admet-163 193 10 t. t. PROPN admet-163 193 11 matsumoto matsumoto PROPN admet-163 193 12 , , PUNCT admet-163 193 13 m. m. NOUN admet-163 193 14 otsuka otsuka PROPN admet-163 193 15 , , PUNCT admet-163 193 16 y. y. PROPN admet-163 193 17 moriyama moriyama PROPN admet-163 193 18 , , PUNCT admet-163 193 19 trends trend NOUN admet-163 193 20 in in ADP admet-163 193 21 pharmacological pharmacological ADJ admet-163 193 22 sciences science NOUN admet-163 193 23 , , PUNCT admet-163 193 24 27 27 NUM admet-163 193 25 ( ( PUNCT admet-163 193 26 2006 2006 NUM admet-163 193 27 ) ) PUNCT admet-163 193 28 587—593 587—593 NUM admet-163 193 29 . . PUNCT admet-163 194 1 [ [ X admet-163 194 2 27 27 NUM admet-163 194 3 ] ] PUNCT admet-163 194 4 m. m. NOUN admet-163 194 5 otsuka otsuka PROPN admet-163 194 6 , , PUNCT admet-163 194 7 t. t. PROPN admet-163 194 8 matsumoto matsumoto PROPN admet-163 194 9 , , PUNCT admet-163 194 10 r. r. PROPN admet-163 194 11 morimoto morimoto PROPN admet-163 194 12 , , PUNCT admet-163 194 13 s. s. PROPN admet-163 194 14 arioka arioka PROPN admet-163 194 15 , , PUNCT admet-163 194 16 h. h. PROPN admet-163 194 17 omote omote PROPN admet-163 194 18 , , PUNCT admet-163 194 19 y. y. PROPN admet-163 194 20 moriyama moriyama PROPN admet-163 194 21 , , PUNCT admet-163 194 22 proceedings proceeding NOUN admet-163 194 23 of of ADP admet-163 194 24 the the DET admet-163 194 25 national national PROPN admet-163 194 26 academy academy PROPN admet-163 194 27 of of ADP admet-163 194 28 sciences sciences PROPN admet-163 194 29 usa usa PROPN admet-163 194 30 , , PUNCT admet-163 194 31 102 102 NUM admet-163 194 32 ( ( PUNCT admet-163 194 33 2005 2005 NUM admet-163 194 34 ) ) PUNCT admet-163 194 35 17923 17923 NUM admet-163 194 36 - - SYM admet-163 194 37 17928 17928 NUM admet-163 194 38 . . PUNCT admet-163 195 1 [ [ X admet-163 195 2 28 28 NUM admet-163 195 3 ] ] X admet-163 195 4 h. h. PROPN admet-163 195 5 osman osman PROPN admet-163 195 6 - - PUNCT admet-163 195 7 ponchet ponchet NOUN admet-163 195 8 , , PUNCT admet-163 195 9 ( ( PUNCT admet-163 195 10 galderma galderma PROPN admet-163 195 11 research research NOUN admet-163 195 12 & & CCONJ admet-163 195 13 development development PROPN admet-163 195 14 ) ) PUNCT admet-163 195 15 , , PUNCT admet-163 195 16 patent patent NOUN admet-163 196 1 wo-2014/184265 wo-2014/184265 NOUN admet-163 196 2 a. a. NOUN admet-163 196 3 © © PROPN admet-163 196 4 2015 2015 NUM admet-163 196 5 by by ADP admet-163 196 6 the the DET admet-163 196 7 authors author NOUN admet-163 196 8 ; ; PUNCT admet-163 196 9 licensee licensee PROPN admet-163 196 10 iapc iapc PROPN admet-163 196 11 , , PUNCT admet-163 196 12 zagreb zagreb PROPN admet-163 196 13 , , PUNCT admet-163 196 14 croatia croatia PROPN admet-163 196 15 . . PUNCT admet-163 197 1 this this DET admet-163 197 2 article article NOUN admet-163 197 3 is be AUX admet-163 197 4 an an DET admet-163 197 5 open open ADJ admet-163 197 6 - - PUNCT admet-163 197 7 access access NOUN admet-163 197 8 article article NOUN admet-163 197 9 distributed distribute VERB admet-163 197 10 under under ADP admet-163 197 11 the the DET admet-163 197 12 terms term NOUN admet-163 197 13 and and CCONJ admet-163 197 14 conditions condition NOUN admet-163 197 15 of of ADP admet-163 197 16 the the DET admet-163 197 17 creative creative ADJ admet-163 197 18 commons common NOUN admet-163 197 19 attribution attribution NOUN admet-163 197 20 license license NOUN admet-163 197 21 ( ( PUNCT admet-163 197 22 http://creativecommons.org/licenses/by/3.0/ http://creativecommons.org/licenses/by/3.0/ PROPN admet-163 197 23 ) ) PUNCT admet-163 197 24 http://creativecommons.org/licenses/by/3.0/ http://creativecommons.org/licenses/by/3.0/ PROPN