id	sid	tid	token	lemma	pos
admet-169	1	1	manuscript	manuscript	PROPN
admet-169	1	2	doi	doi	PROPN
admet-169	1	3	:	:	PUNCT
admet-169	1	4	10.5599	10.5599	NUM
admet-169	1	5	/	/	SYM
admet-169	1	6	admet.3.1.169	admet.3.1.169	PROPN
admet-169	1	7	51	51	NUM
admet-169	1	8	admet	admet	NOUN
admet-169	1	9	&	&	CCONJ
admet-169	1	10	dmpk	dmpk	PROPN
admet-169	1	11	3(1	3(1	NUM
admet-169	1	12	)	)	PUNCT
admet-169	1	13	(	(	PUNCT
admet-169	1	14	2015	2015	NUM
admet-169	1	15	)	)	PUNCT
admet-169	1	16	51	51	NUM
admet-169	1	17	-	-	SYM
admet-169	1	18	67	67	NUM
admet-169	1	19	;	;	PUNCT
admet-169	1	20	doi	doi	NOUN
admet-169	1	21	:	:	PUNCT
admet-169	1	22	10.5599	10.5599	NUM
admet-169	1	23	/	/	SYM
admet-169	1	24	admet.3.1.169	admet.3.1.169	VERB
admet-169	1	25	open	open	ADJ
admet-169	1	26	access	access	NOUN
admet-169	1	27	:	:	PUNCT
admet-169	1	28	issn	issn	PROPN
admet-169	1	29	:	:	PUNCT
admet-169	1	30	1848	1848	NUM
admet-169	1	31	-	-	SYM
admet-169	1	32	7718	7718	NUM
admet-169	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-169	1	34	original	original	ADJ
admet-169	1	35	scientific	scientific	ADJ
admet-169	1	36	paper	paper	NOUN
admet-169	1	37	adaptation	adaptation	NOUN
admet-169	1	38	of	of	ADP
admet-169	1	39	a	a	DET
admet-169	1	40	human	human	ADJ
admet-169	1	41	gut	gut	NOUN
admet-169	1	42	epithelial	epithelial	ADJ
admet-169	1	43	model	model	NOUN
admet-169	1	44	in	in	ADP
admet-169	1	45	relation	relation	NOUN
admet-169	1	46	to	to	ADP
admet-169	1	47	the	the	DET
admet-169	1	48	assessment	assessment	NOUN
admet-169	1	49	of	of	ADP
admet-169	1	50	clinical	clinical	ADJ
admet-169	1	51	pharmacokinetic	pharmacokinetic	ADJ
admet-169	1	52	parameters	parameter	NOUN
admet-169	1	53	for	for	ADP
admet-169	1	54	selected	select	VERB
admet-169	1	55	tyrosine	tyrosine	NOUN
admet-169	1	56	kinase	kinase	PROPN
admet-169	1	57	inhibitors	inhibitors	PROPN
admet-169	1	58	richard	richard	PROPN
admet-169	1	59	j	j	PROPN
admet-169	1	60	honeywell	honeywell	PROPN
admet-169	1	61	,	,	PUNCT
admet-169	1	62	christien	christien	NOUN
admet-169	1	63	fatmawati	fatmawati	PROPN
admet-169	1	64	,	,	PUNCT
admet-169	1	65	marita	marita	PROPN
admet-169	1	66	buddha	buddha	PROPN
admet-169	1	67	;	;	PUNCT
admet-169	1	68	sarina	sarina	PROPN
admet-169	1	69	hitzerd	hitzerd	PROPN
admet-169	1	70	,	,	PUNCT
admet-169	1	71	ietje	ietje	NOUN
admet-169	1	72	kathman	kathman	PROPN
admet-169	1	73	and	and	CCONJ
admet-169	1	74	godefridus	godefridus	PROPN
admet-169	1	75	j.	j.	PROPN
admet-169	1	76	peters	peters	PROPN
admet-169	1	77	*	*	PUNCT
admet-169	1	78	dept	dept	PROPN
admet-169	1	79	.	.	PROPN
admet-169	1	80	of	of	ADP
admet-169	1	81	medical	medical	ADJ
admet-169	1	82	oncology	oncology	NOUN
admet-169	1	83	,	,	PUNCT
admet-169	1	84	vu	vu	PROPN
admet-169	1	85	university	university	PROPN
admet-169	1	86	medical	medical	ADJ
admet-169	1	87	center	center	NOUN
admet-169	1	88	,	,	PUNCT
admet-169	1	89	po	po	PROPN
admet-169	1	90	box	box	PROPN
admet-169	1	91	7057	7057	NUM
admet-169	1	92	,	,	PUNCT
admet-169	1	93	1007	1007	NUM
admet-169	1	94	mb	mb	ADP
admet-169	1	95	amsterdam	amsterdam	PROPN
admet-169	1	96	,	,	PUNCT
admet-169	1	97	the	the	DET
admet-169	1	98	netherlands	netherlands	PROPN
admet-169	1	99	*	*	PUNCT
admet-169	1	100	corresponding	correspond	VERB
admet-169	1	101	author	author	NOUN
admet-169	1	102	,	,	PUNCT
admet-169	1	103	e	e	NOUN
admet-169	1	104	-	-	NOUN
admet-169	1	105	mail	mail	NOUN
admet-169	1	106	:	:	PUNCT
admet-169	1	107	gj.peters@vumc.nl	gj.peters@vumc.nl	NOUN
admet-169	1	108	,	,	PUNCT
admet-169	1	109	tel	tel	ADP
admet-169	1	110	:	:	PUNCT
admet-169	1	111	+3120	+3120	NUM
admet-169	1	112	444	444	NUM
admet-169	1	113	2633	2633	NUM
admet-169	1	114	,	,	PUNCT
admet-169	1	115	fax	fax	NOUN
admet-169	1	116	:	:	PUNCT
admet-169	1	117	+3120	+3120	NUM
admet-169	1	118	444	444	NUM
admet-169	1	119	3844	3844	NUM
admet-169	1	120	,	,	PUNCT
admet-169	1	121	received	receive	VERB
admet-169	1	122	:	:	PUNCT
admet-169	1	123	february	february	PROPN
admet-169	1	124	19	19	NUM
admet-169	1	125	,	,	PUNCT
admet-169	1	126	2015	2015	NUM
admet-169	1	127	;	;	PUNCT
admet-169	1	128	revised	revise	VERB
admet-169	1	129	:	:	PUNCT
admet-169	1	130	march	march	PROPN
admet-169	1	131	24	24	NUM
admet-169	1	132	,	,	PUNCT
admet-169	1	133	2015	2015	NUM
admet-169	1	134	;	;	PUNCT
admet-169	1	135	published	publish	VERB
admet-169	1	136	:	:	PUNCT
admet-169	1	137	march	march	PROPN
admet-169	1	138	31	31	NUM
admet-169	1	139	,	,	PUNCT
admet-169	1	140	2015	2015	NUM
admet-169	1	141	abstract	abstract	NOUN
admet-169	1	142	the	the	DET
admet-169	1	143	absorption	absorption	NOUN
admet-169	1	144	,	,	PUNCT
admet-169	1	145	efflux	efflux	NOUN
admet-169	1	146	and	and	CCONJ
admet-169	1	147	transport	transport	NOUN
admet-169	1	148	properties	property	NOUN
admet-169	1	149	of	of	ADP
admet-169	1	150	two	two	NUM
admet-169	1	151	of	of	ADP
admet-169	1	152	the	the	DET
admet-169	1	153	most	most	ADV
admet-169	1	154	commonly	commonly	ADV
admet-169	1	155	used	use	VERB
admet-169	1	156	tyrosine	tyrosine	NOUN
admet-169	1	157	kinase	kinase	PROPN
admet-169	1	158	inhibitors	inhibitor	NOUN
admet-169	1	159	(	(	PUNCT
admet-169	1	160	tkis	tkis	NOUN
admet-169	1	161	)	)	PUNCT
admet-169	1	162	,	,	PUNCT
admet-169	1	163	erlotinib	erlotinib	NOUN
admet-169	1	164	(	(	PUNCT
admet-169	1	165	e	e	NOUN
admet-169	1	166	)	)	PUNCT
admet-169	1	167	and	and	CCONJ
admet-169	1	168	gefitinib	gefitinib	NOUN
admet-169	1	169	(	(	PUNCT
admet-169	1	170	g	g	NOUN
admet-169	1	171	)	)	PUNCT
admet-169	1	172	were	be	AUX
admet-169	1	173	investigated	investigate	VERB
admet-169	1	174	using	use	VERB
admet-169	1	175	an	an	DET
admet-169	1	176	adapted	adapt	VERB
admet-169	1	177	workable	workable	ADJ
admet-169	1	178	methodology	methodology	NOUN
admet-169	1	179	of	of	ADP
admet-169	1	180	a	a	DET
admet-169	1	181	3	3	NUM
admet-169	1	182	-	-	PUNCT
admet-169	1	183	day	day	NOUN
admet-169	1	184	caco-2	caco-2	NUM
admet-169	1	185	cell	cell	NOUN
admet-169	1	186	monolayer	monolayer	NOUN
admet-169	1	187	transwell	transwell	NOUN
admet-169	1	188	system	system	NOUN
admet-169	1	189	,	,	PUNCT
admet-169	1	190	a	a	DET
admet-169	1	191	standard	standard	ADJ
admet-169	1	192	model	model	NOUN
admet-169	1	193	to	to	PART
admet-169	1	194	test	test	VERB
admet-169	1	195	drug	drug	NOUN
admet-169	1	196	permeability	permeability	NOUN
admet-169	1	197	and	and	CCONJ
admet-169	1	198	uptake	uptake	NOUN
admet-169	1	199	of	of	ADP
admet-169	1	200	orally	orally	ADV
admet-169	1	201	administered	administer	VERB
admet-169	1	202	compounds	compound	NOUN
admet-169	1	203	.	.	PUNCT
admet-169	2	1	monolayer	monolayer	NOUN
admet-169	2	2	integrity	integrity	NOUN
admet-169	2	3	was	be	AUX
admet-169	2	4	tested	test	VERB
admet-169	2	5	using	use	VERB
admet-169	2	6	trans	trans	ADJ
admet-169	2	7	-	-	ADJ
admet-169	2	8	epithelial	epithelial	ADJ
admet-169	2	9	electrical	electrical	ADJ
admet-169	2	10	resistance	resistance	NOUN
admet-169	2	11	(	(	PUNCT
admet-169	2	12	teer	teer	NOUN
admet-169	2	13	)	)	PUNCT
admet-169	2	14	measurements	measurement	NOUN
admet-169	2	15	,	,	PUNCT
admet-169	2	16	while	while	SCONJ
admet-169	2	17	drug	drug	NOUN
admet-169	2	18	concentrations	concentration	NOUN
admet-169	2	19	were	be	AUX
admet-169	2	20	determined	determine	VERB
admet-169	2	21	with	with	ADP
admet-169	2	22	a	a	DET
admet-169	2	23	validated	validate	VERB
admet-169	2	24	lc	lc	NOUN
admet-169	2	25	-	-	PUNCT
admet-169	2	26	ms/	ms/	NOUN
admet-169	2	27	ms	ms	NOUN
admet-169	2	28	technique	technique	NOUN
admet-169	2	29	.	.	PUNCT
admet-169	3	1	addition	addition	NOUN
admet-169	3	2	of	of	ADP
admet-169	3	3	5	5	NUM
admet-169	3	4	%	%	NOUN
admet-169	3	5	bovine	bovine	NOUN
admet-169	3	6	serum	serum	NOUN
admet-169	3	7	albumin	albumin	PROPN
admet-169	3	8	(	(	PUNCT
admet-169	3	9	bsa	bsa	PROPN
admet-169	3	10	)	)	PUNCT
admet-169	3	11	maintained	maintain	VERB
admet-169	3	12	drug	drug	NOUN
admet-169	3	13	concentrations	concentration	NOUN
admet-169	3	14	at	at	ADP
admet-169	3	15	±	±	NUM
admet-169	3	16	20	20	NUM
admet-169	3	17	µm	µm	NOUN
admet-169	3	18	through	through	ADP
admet-169	3	19	the	the	DET
admet-169	3	20	avoidance	avoidance	NOUN
admet-169	3	21	of	of	ADP
admet-169	3	22	chelate	chelate	NOUN
admet-169	3	23	formation	formation	NOUN
admet-169	3	24	,	,	PUNCT
admet-169	3	25	(	(	PUNCT
admet-169	3	26	nevertheless	nevertheless	ADV
admet-169	3	27	,	,	PUNCT
admet-169	3	28	a	a	DET
admet-169	3	29	reduced	reduce	VERB
admet-169	3	30	accumulative	accumulative	ADJ
admet-169	3	31	mass	mass	NOUN
admet-169	3	32	transport	transport	NOUN
admet-169	3	33	of	of	ADP
admet-169	3	34	the	the	DET
admet-169	3	35	protein	protein	NOUN
admet-169	3	36	bound	bind	VERB
admet-169	3	37	drug	drug	NOUN
admet-169	3	38	was	be	AUX
admet-169	3	39	observed	observe	VERB
admet-169	3	40	)	)	PUNCT
admet-169	3	41	.	.	PUNCT
admet-169	4	1	investigation	investigation	NOUN
admet-169	4	2	with	with	ADP
admet-169	4	3	ko143	ko143	PROPN
admet-169	4	4	(	(	PUNCT
admet-169	4	5	a	a	DET
admet-169	4	6	specific	specific	ADJ
admet-169	4	7	blocker	blocker	NOUN
admet-169	4	8	of	of	ADP
admet-169	4	9	abcg2	abcg2	NOUN
admet-169	4	10	)	)	PUNCT
admet-169	4	11	or	or	CCONJ
admet-169	4	12	nan3	nan3	PROPN
admet-169	4	13	(	(	PUNCT
admet-169	4	14	a	a	DET
admet-169	4	15	metabolic	metabolic	NOUN
admet-169	4	16	inhibitor	inhibitor	NOUN
admet-169	4	17	)	)	PUNCT
admet-169	4	18	indicated	indicate	VERB
admet-169	4	19	an	an	DET
admet-169	4	20	interplay	interplay	NOUN
admet-169	4	21	between	between	ADP
admet-169	4	22	active	active	ADJ
admet-169	4	23	transport	transport	NOUN
admet-169	4	24	and	and	CCONJ
admet-169	4	25	to	to	ADP
admet-169	4	26	a	a	DET
admet-169	4	27	less	less	ADV
admet-169	4	28	degree	degree	NOUN
admet-169	4	29	passive	passive	ADJ
admet-169	4	30	diffusion	diffusion	NOUN
admet-169	4	31	for	for	ADP
admet-169	4	32	gefitinib	gefitinib	NOUN
admet-169	4	33	.	.	PUNCT
admet-169	5	1	however	however	ADV
admet-169	5	2	,	,	PUNCT
admet-169	5	3	for	for	ADP
admet-169	5	4	erlotinib	erlotinib	NOUN
admet-169	5	5	results	result	NOUN
admet-169	5	6	indicate	indicate	VERB
admet-169	5	7	a	a	DET
admet-169	5	8	more	more	ADV
admet-169	5	9	dominant	dominant	ADJ
admet-169	5	10	passive	passive	ADJ
admet-169	5	11	diffusion	diffusion	NOUN
admet-169	5	12	supported	support	VERB
admet-169	5	13	by	by	ADP
admet-169	5	14	one	one	NUM
admet-169	5	15	or	or	CCONJ
admet-169	5	16	more	more	ADV
admet-169	5	17	active	active	ADJ
admet-169	5	18	transport	transport	NOUN
admet-169	5	19	mechanisms	mechanism	NOUN
admet-169	5	20	.	.	PUNCT
admet-169	6	1	the	the	DET
admet-169	6	2	use	use	NOUN
admet-169	6	3	of	of	ADP
admet-169	6	4	ko143	ko143	PROPN
admet-169	6	5	suggests	suggest	VERB
admet-169	6	6	that	that	SCONJ
admet-169	6	7	abcg2	abcg2	NOUN
admet-169	6	8	is	be	AUX
admet-169	6	9	partially	partially	ADV
admet-169	6	10	involved	involve	VERB
admet-169	6	11	with	with	ADP
admet-169	6	12	accumulation	accumulation	NOUN
admet-169	6	13	of	of	ADP
admet-169	6	14	both	both	CCONJ
admet-169	6	15	erlotinib	erlotinib	NOUN
admet-169	6	16	and	and	CCONJ
admet-169	6	17	gefitinib	gefitinib	NOUN
admet-169	6	18	in	in	ADP
admet-169	6	19	the	the	DET
admet-169	6	20	intestinal	intestinal	ADJ
admet-169	6	21	cell	cell	NOUN
admet-169	6	22	.	.	PUNCT
admet-169	7	1	this	this	DET
admet-169	7	2	adapted	adapt	VERB
admet-169	7	3	methodology	methodology	NOUN
admet-169	7	4	is	be	AUX
admet-169	7	5	well	well	ADV
admet-169	7	6	suited	suited	ADJ
admet-169	7	7	for	for	ADP
admet-169	7	8	absorption	absorption	NOUN
admet-169	7	9	,	,	PUNCT
admet-169	7	10	efflux	efflux	NOUN
admet-169	7	11	and	and	CCONJ
admet-169	7	12	transport	transport	NOUN
admet-169	7	13	studies	study	NOUN
admet-169	7	14	and	and	CCONJ
admet-169	7	15	may	may	AUX
admet-169	7	16	be	be	AUX
admet-169	7	17	extended	extend	VERB
admet-169	7	18	to	to	PART
admet-169	7	19	investigate	investigate	VERB
admet-169	7	20	the	the	DET
admet-169	7	21	dominant	dominant	ADJ
admet-169	7	22	mechanism	mechanism	NOUN
admet-169	7	23	involved	involve	VERB
admet-169	7	24	in	in	ADP
admet-169	7	25	the	the	DET
admet-169	7	26	transport	transport	NOUN
admet-169	7	27	of	of	ADP
admet-169	7	28	tkis	tkis	PROPN
admet-169	7	29	.	.	PUNCT
admet-169	8	1	keywords	keyword	VERB
admet-169	8	2	tyrosine	tyrosine	PROPN
admet-169	8	3	kinase	kinase	PROPN
admet-169	8	4	inhibitors	inhibitor	NOUN
admet-169	8	5	;	;	PUNCT
admet-169	8	6	caco-2	caco-2	NUM
admet-169	8	7	,	,	PUNCT
admet-169	8	8	transwell	transwell	NOUN
admet-169	8	9	;	;	PUNCT
admet-169	8	10	gut	gut	NOUN
admet-169	8	11	epithelial	epithelial	NOUN
admet-169	8	12	;	;	PUNCT
admet-169	8	13	gut	gut	NOUN
admet-169	8	14	model	model	NOUN
admet-169	8	15	;	;	PUNCT
admet-169	8	16	drug	drug	NOUN
admet-169	8	17	absorption	absorption	NOUN
admet-169	8	18	.	.	PUNCT
admet-169	9	1	introduction	introduction	NOUN
admet-169	9	2	in	in	ADP
admet-169	9	3	recent	recent	ADJ
admet-169	9	4	years	year	NOUN
admet-169	9	5	,	,	PUNCT
admet-169	9	6	approaches	approach	NOUN
admet-169	9	7	to	to	ADP
admet-169	9	8	treatment	treatment	NOUN
admet-169	9	9	of	of	ADP
admet-169	9	10	various	various	ADJ
admet-169	9	11	different	different	ADJ
admet-169	9	12	oncological	oncological	ADJ
admet-169	9	13	disorders	disorder	NOUN
admet-169	9	14	have	have	AUX
admet-169	9	15	been	be	AUX
admet-169	9	16	directed	direct	VERB
admet-169	9	17	towards	towards	ADP
admet-169	9	18	the	the	DET
admet-169	9	19	application	application	NOUN
admet-169	9	20	of	of	ADP
admet-169	9	21	a	a	DET
admet-169	9	22	series	series	NOUN
admet-169	9	23	of	of	ADP
admet-169	9	24	small	small	ADJ
admet-169	9	25	molecules	molecule	NOUN
admet-169	9	26	referred	refer	VERB
admet-169	9	27	to	to	ADP
admet-169	9	28	as	as	SCONJ
admet-169	9	29	tyrosine	tyrosine	PROPN
admet-169	9	30	kinase	kinase	PROPN
admet-169	9	31	inhibitors	inhibitor	NOUN
admet-169	9	32	(	(	PUNCT
admet-169	9	33	tkis	tkis	NOUN
admet-169	9	34	)	)	PUNCT
admet-169	9	35	.	.	PUNCT
admet-169	10	1	this	this	DET
admet-169	10	2	loosely	loosely	ADV
admet-169	10	3	related	relate	VERB
admet-169	10	4	family	family	NOUN
admet-169	10	5	of	of	ADP
admet-169	10	6	molecules	molecule	NOUN
admet-169	10	7	specifically	specifically	ADV
admet-169	10	8	target	target	VERB
admet-169	10	9	the	the	DET
admet-169	10	10	tyrosine	tyrosine	NOUN
admet-169	10	11	kinase	kinase	PROPN
admet-169	10	12	domain	domain	NOUN
admet-169	10	13	of	of	ADP
admet-169	10	14	growth	growth	NOUN
admet-169	10	15	factor	factor	NOUN
admet-169	10	16	receptors	receptor	NOUN
admet-169	10	17	in	in	ADP
admet-169	10	18	the	the	DET
admet-169	10	19	cellular	cellular	ADJ
admet-169	10	20	membrane	membrane	NOUN
admet-169	10	21	or	or	CCONJ
admet-169	10	22	cytosol	cytosol	NOUN
admet-169	10	23	which	which	PRON
admet-169	10	24	play	play	VERB
admet-169	10	25	an	an	DET
admet-169	10	26	important	important	ADJ
admet-169	10	27	role	role	NOUN
admet-169	10	28	in	in	ADP
admet-169	10	29	the	the	DET
admet-169	10	30	control	control	NOUN
admet-169	10	31	of	of	ADP
admet-169	10	32	cell	cell	NOUN
admet-169	10	33	growth	growth	NOUN
admet-169	10	34	and	and	CCONJ
admet-169	10	35	replication	replication	NOUN
admet-169	10	36	[	[	X
admet-169	10	37	1	1	NUM
admet-169	10	38	-	-	SYM
admet-169	10	39	4	4	NUM
admet-169	10	40	]	]	PUNCT
admet-169	10	41	.	.	PUNCT
admet-169	11	1	two	two	NUM
admet-169	11	2	of	of	ADP
admet-169	11	3	the	the	DET
admet-169	11	4	most	most	ADV
admet-169	11	5	commonly	commonly	ADV
admet-169	11	6	used	use	VERB
admet-169	11	7	tkis	tkis	PROPN
admet-169	11	8	are	be	AUX
admet-169	11	9	erlotinib	erlotinib	NOUN
admet-169	11	10	(	(	PUNCT
admet-169	11	11	non	non	ADJ
admet-169	11	12	-	-	ADJ
admet-169	11	13	small	small	ADJ
admet-169	11	14	cell	cell	NOUN
admet-169	11	15	lung	lung	NOUN
admet-169	11	16	cancer	cancer	NOUN
admet-169	11	17	(	(	PUNCT
admet-169	11	18	nsclc	nsclc	NOUN
admet-169	11	19	)	)	PUNCT
admet-169	11	20	,	,	PUNCT
admet-169	11	21	pancreatic	pancreatic	ADJ
admet-169	11	22	cancer	cancer	NOUN
admet-169	11	23	(	(	PUNCT
admet-169	11	24	pc	pc	NOUN
admet-169	11	25	)	)	PUNCT
admet-169	11	26	)	)	PUNCT
admet-169	11	27	and	and	CCONJ
admet-169	11	28	gefitinib	gefitinib	NOUN
admet-169	11	29	(	(	PUNCT
admet-169	11	30	nsclc	nsclc	NOUN
admet-169	11	31	)	)	PUNCT
admet-169	12	1	[	[	X
admet-169	12	2	5	5	NUM
admet-169	12	3	]	]	PUNCT
admet-169	12	4	.	.	PUNCT
admet-169	13	1	erlotinib	erlotinib	NOUN
admet-169	13	2	and	and	CCONJ
admet-169	13	3	gefitinib	gefitinib	NOUN
admet-169	13	4	both	both	PRON
admet-169	13	5	show	show	VERB
admet-169	13	6	similarity	similarity	NOUN
admet-169	13	7	in	in	ADP
admet-169	13	8	their	their	PRON
admet-169	13	9	basic	basic	ADJ
admet-169	13	10	structure	structure	NOUN
admet-169	13	11	with	with	ADP
admet-169	13	12	a	a	DET
admet-169	13	13	central	central	ADJ
admet-169	13	14	pyrimidine	pyrimidine	NOUN
admet-169	13	15	core	core	NOUN
admet-169	13	16	,	,	PUNCT
admet-169	13	17	an	an	DET
admet-169	13	18	adenosine	adenosine	ADJ
admet-169	13	19	triphosphate	triphosphate	NOUN
admet-169	13	20	(	(	PUNCT
admet-169	13	21	atp	atp	PROPN
admet-169	13	22	)	)	PUNCT
admet-169	13	23	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-169	13	24	mailto:gj.peters@vumc.nl	mailto:gj.peters@vumc.nl	PROPN
admet-169	13	25	peters	peters	PROPN
admet-169	13	26	et	et	PROPN
admet-169	13	27	al	al	PROPN
admet-169	13	28	.	.	PROPN
admet-169	13	29	admet	admet	PROPN
admet-169	13	30	&	&	CCONJ
admet-169	13	31	dmpk	dmpk	PROPN
admet-169	13	32	3(1	3(1	NUM
admet-169	13	33	)	)	PUNCT
admet-169	13	34	(	(	PUNCT
admet-169	13	35	2015	2015	NUM
admet-169	13	36	)	)	PUNCT
admet-169	13	37	51	51	NUM
admet-169	13	38	-	-	SYM
admet-169	13	39	67	67	NUM
admet-169	13	40	52	52	NUM
admet-169	13	41	binding	bind	VERB
admet-169	13	42	side	side	NOUN
admet-169	13	43	chain	chain	NOUN
admet-169	13	44	and	and	CCONJ
admet-169	13	45	a	a	DET
admet-169	13	46	basic	basic	ADJ
admet-169	13	47	side	side	NOUN
admet-169	13	48	chain	chain	NOUN
admet-169	13	49	(	(	PUNCT
admet-169	13	50	figure	figure	NOUN
admet-169	13	51	1	1	NUM
admet-169	13	52	)	)	PUNCT
admet-169	13	53	.	.	PUNCT
admet-169	14	1	both	both	DET
admet-169	14	2	gefitinib	gefitinib	NOUN
admet-169	14	3	and	and	CCONJ
admet-169	14	4	erlotinib	erlotinib	NOUN
admet-169	14	5	specifically	specifically	ADV
admet-169	14	6	target	target	VERB
admet-169	14	7	epidermal	epidermal	ADJ
admet-169	14	8	growth	growth	NOUN
admet-169	14	9	factor	factor	NOUN
admet-169	14	10	receptor	receptor	NOUN
admet-169	14	11	(	(	PUNCT
admet-169	14	12	egfr	egfr	X
admet-169	14	13	)	)	PUNCT
admet-169	15	1	[	[	X
admet-169	15	2	6	6	NUM
admet-169	15	3	]	]	PUNCT
admet-169	15	4	.	.	PUNCT
admet-169	16	1	figure	figure	NOUN
admet-169	16	2	1	1	NUM
admet-169	16	3	.	.	PUNCT
admet-169	17	1	the	the	DET
admet-169	17	2	physical	physical	ADJ
admet-169	17	3	and	and	CCONJ
admet-169	17	4	chemical	chemical	NOUN
admet-169	17	5	properties	property	NOUN
admet-169	17	6	for	for	ADP
admet-169	17	7	gefitinib	gefitinib	NOUN
admet-169	17	8	(	(	PUNCT
admet-169	17	9	ge	ge	PROPN
admet-169	17	10	)	)	PUNCT
admet-169	17	11	and	and	CCONJ
admet-169	17	12	erlotinib	erlotinib	NOUN
admet-169	17	13	(	(	PUNCT
admet-169	17	14	er	er	INTJ
admet-169	17	15	)	)	PUNCT
admet-169	17	16	.	.	PUNCT
admet-169	18	1	log	log	PROPN
admet-169	18	2	p	p	NOUN
admet-169	18	3	is	be	AUX
admet-169	18	4	estimated	estimate	VERB
admet-169	18	5	by	by	ADP
admet-169	18	6	viswanadhan	viswanadhan	PROPN
admet-169	18	7	’s	’s	PART
admet-169	18	8	fragmentation	fragmentation	NOUN
admet-169	19	1	[	[	X
admet-169	19	2	7	7	NUM
admet-169	19	3	]	]	PUNCT
admet-169	19	4	.	.	PUNCT
admet-169	20	1	tkis	tkis	PROPN
admet-169	20	2	represent	represent	VERB
admet-169	20	3	an	an	DET
admet-169	20	4	orally	orally	ADV
admet-169	20	5	self	self	NOUN
admet-169	20	6	-	-	PUNCT
admet-169	20	7	administered	administer	VERB
admet-169	20	8	treatment	treatment	NOUN
admet-169	20	9	that	that	PRON
admet-169	20	10	can	can	AUX
admet-169	20	11	be	be	AUX
admet-169	20	12	handled	handle	VERB
admet-169	20	13	on	on	ADP
admet-169	20	14	an	an	DET
admet-169	20	15	outpatient	outpatient	NOUN
admet-169	20	16	basis	basis	NOUN
admet-169	20	17	.	.	PUNCT
admet-169	21	1	oral	oral	ADJ
admet-169	21	2	administration	administration	NOUN
admet-169	21	3	has	have	VERB
admet-169	21	4	a	a	DET
admet-169	21	5	lot	lot	NOUN
admet-169	21	6	of	of	ADP
admet-169	21	7	beneficial	beneficial	ADJ
admet-169	21	8	aspects	aspect	NOUN
admet-169	21	9	such	such	ADJ
admet-169	21	10	as	as	ADP
admet-169	21	11	ease	ease	NOUN
admet-169	21	12	of	of	ADP
admet-169	21	13	use	use	NOUN
admet-169	21	14	and	and	CCONJ
admet-169	21	15	suitability	suitability	NOUN
admet-169	21	16	for	for	ADP
admet-169	21	17	long	long	ADJ
admet-169	21	18	term	term	NOUN
admet-169	21	19	treatment	treatment	NOUN
admet-169	21	20	.	.	PUNCT
admet-169	22	1	however	however	ADV
admet-169	22	2	,	,	PUNCT
admet-169	22	3	resistance	resistance	NOUN
admet-169	22	4	to	to	ADP
admet-169	22	5	these	these	DET
admet-169	22	6	molecules	molecule	NOUN
admet-169	22	7	can	can	AUX
admet-169	22	8	develop	develop	VERB
admet-169	22	9	over	over	ADP
admet-169	22	10	time	time	NOUN
admet-169	22	11	.	.	PUNCT
admet-169	23	1	this	this	PRON
admet-169	23	2	may	may	AUX
admet-169	23	3	be	be	AUX
admet-169	23	4	mediated	mediate	VERB
admet-169	23	5	by	by	ADP
admet-169	23	6	one	one	NUM
admet-169	23	7	of	of	ADP
admet-169	23	8	the	the	DET
admet-169	23	9	multidrug	multidrug	NOUN
admet-169	23	10	resistance	resistance	NOUN
admet-169	23	11	(	(	PUNCT
admet-169	23	12	mdr	mdr	NOUN
admet-169	23	13	)	)	PUNCT
admet-169	23	14	proteins	protein	NOUN
admet-169	23	15	which	which	PRON
admet-169	23	16	form	form	VERB
admet-169	23	17	a	a	DET
admet-169	23	18	group	group	NOUN
admet-169	23	19	of	of	ADP
admet-169	23	20	active	active	ADJ
admet-169	23	21	efflux	efflux	NOUN
admet-169	23	22	pumps	pump	NOUN
admet-169	23	23	of	of	ADP
admet-169	23	24	the	the	DET
admet-169	23	25	atp	atp	NOUN
admet-169	23	26	binding	bind	VERB
admet-169	23	27	-	-	PUNCT
admet-169	23	28	cassette	cassette	NOUN
admet-169	23	29	(	(	PUNCT
admet-169	23	30	abc	abc	PROPN
admet-169	23	31	)	)	PUNCT
admet-169	23	32	drug	drug	NOUN
admet-169	23	33	transporters	transporter	NOUN
admet-169	23	34	;	;	PUNCT
admet-169	23	35	the	the	DET
admet-169	23	36	pumps	pump	NOUN
admet-169	23	37	may	may	AUX
admet-169	23	38	catalyze	catalyze	VERB
admet-169	23	39	the	the	DET
admet-169	23	40	efflux	efflux	NOUN
admet-169	23	41	of	of	ADP
admet-169	23	42	tkis	tkis	NOUN
admet-169	23	43	out	out	ADP
admet-169	23	44	of	of	ADP
admet-169	23	45	the	the	DET
admet-169	23	46	enterocyte	enterocyte	NOUN
admet-169	23	47	cells	cell	NOUN
admet-169	23	48	[	[	X
admet-169	23	49	8	8	NUM
admet-169	23	50	-	-	SYM
admet-169	23	51	10	10	NUM
admet-169	23	52	]	]	PUNCT
admet-169	23	53	.	.	PUNCT
admet-169	24	1	there	there	PRON
admet-169	24	2	are	be	VERB
admet-169	24	3	seven	seven	NUM
admet-169	24	4	subfamilies	subfamily	NOUN
admet-169	24	5	of	of	ADP
admet-169	24	6	abc	abc	PROPN
admet-169	24	7	efflux	efflux	NOUN
admet-169	24	8	transporter	transporter	NOUN
admet-169	24	9	(	(	PUNCT
admet-169	24	10	abca	abca	NOUN
admet-169	24	11	–	–	PUNCT
admet-169	24	12	abcg	abcg	ADV
admet-169	24	13	)	)	PUNCT
admet-169	24	14	based	base	VERB
admet-169	24	15	on	on	ADP
admet-169	24	16	their	their	PRON
admet-169	24	17	domain	domain	NOUN
admet-169	24	18	structure	structure	NOUN
admet-169	24	19	[	[	X
admet-169	24	20	11	11	NUM
admet-169	24	21	]	]	PUNCT
admet-169	24	22	.	.	PUNCT
admet-169	25	1	drug	drug	NOUN
admet-169	25	2	interaction	interaction	NOUN
admet-169	25	3	with	with	ADP
admet-169	25	4	the	the	DET
admet-169	25	5	efflux	efflux	NOUN
admet-169	25	6	transporter	transporter	NOUN
admet-169	25	7	as	as	ADP
admet-169	25	8	a	a	DET
admet-169	25	9	substrate	substrate	NOUN
admet-169	25	10	or	or	CCONJ
admet-169	25	11	an	an	DET
admet-169	25	12	inhibitor	inhibitor	NOUN
admet-169	25	13	depends	depend	VERB
admet-169	25	14	on	on	ADP
admet-169	25	15	the	the	DET
admet-169	25	16	concentration	concentration	NOUN
admet-169	25	17	of	of	ADP
admet-169	25	18	drugs	drug	NOUN
admet-169	25	19	,	,	PUNCT
admet-169	25	20	for	for	ADP
admet-169	25	21	example	example	NOUN
admet-169	25	22	abcg2	abcg2	NOUN
admet-169	25	23	may	may	AUX
admet-169	25	24	transport	transport	VERB
admet-169	25	25	substrates	substrate	NOUN
admet-169	25	26	like	like	ADP
admet-169	25	27	erlotinib	erlotinib	NOUN
admet-169	25	28	and	and	CCONJ
admet-169	25	29	gefitinib	gefitinib	NOUN
admet-169	25	30	at	at	ADP
admet-169	25	31	low	low	ADJ
admet-169	25	32	concentrations	concentration	NOUN
admet-169	25	33	(	(	PUNCT
admet-169	25	34	0.1	0.1	NUM
admet-169	25	35	–	–	SYM
admet-169	25	36	1	1	NUM
admet-169	25	37	μm	μm	NUM
admet-169	25	38	)	)	PUNCT
admet-169	26	1	[	[	X
admet-169	26	2	11	11	NUM
admet-169	26	3	]	]	PUNCT
admet-169	26	4	,	,	PUNCT
admet-169	26	5	but	but	CCONJ
admet-169	26	6	shows	show	VERB
admet-169	26	7	inhibitory	inhibitory	ADJ
admet-169	26	8	reaction	reaction	NOUN
admet-169	26	9	with	with	ADP
admet-169	26	10	these	these	DET
admet-169	26	11	drugs	drug	NOUN
admet-169	26	12	at	at	ADP
admet-169	26	13	higher	high	ADJ
admet-169	26	14	concentrations	concentration	NOUN
admet-169	27	1	[	[	X
admet-169	27	2	12	12	NUM
admet-169	27	3	-	-	SYM
admet-169	27	4	15	15	NUM
admet-169	27	5	]	]	PUNCT
admet-169	27	6	.	.	PUNCT
admet-169	28	1	the	the	DET
admet-169	28	2	abcg2	abcg2	NOUN
admet-169	28	3	might	might	AUX
admet-169	28	4	transport	transport	VERB
admet-169	28	5	substrates	substrate	NOUN
admet-169	28	6	in	in	ADP
admet-169	28	7	the	the	DET
admet-169	28	8	same	same	ADJ
admet-169	28	9	way	way	NOUN
admet-169	28	10	as	as	ADP
admet-169	28	11	abcb1	abcb1	NOUN
admet-169	28	12	that	that	PRON
admet-169	28	13	expels	expel	VERB
admet-169	28	14	the	the	DET
admet-169	28	15	drugs	drug	NOUN
admet-169	28	16	out	out	ADP
admet-169	28	17	of	of	ADP
admet-169	28	18	the	the	DET
admet-169	28	19	cell	cell	NOUN
admet-169	28	20	or	or	CCONJ
admet-169	28	21	only	only	ADV
admet-169	28	22	translocate	translocate	VERB
admet-169	28	23	them	they	PRON
admet-169	28	24	inside	inside	ADV
admet-169	28	25	of	of	ADP
admet-169	28	26	the	the	DET
admet-169	28	27	cell	cell	NOUN
admet-169	28	28	[	[	X
admet-169	28	29	15	15	NUM
admet-169	28	30	]	]	X
admet-169	28	31	,	,	PUNCT
admet-169	28	32	for	for	ADP
admet-169	28	33	which	which	PRON
admet-169	28	34	both	both	DET
admet-169	28	35	conditions	condition	NOUN
admet-169	28	36	are	be	AUX
admet-169	28	37	lessening	lessen	VERB
admet-169	28	38	the	the	DET
admet-169	28	39	effectiveness	effectiveness	NOUN
admet-169	28	40	of	of	ADP
admet-169	28	41	treatment	treatment	NOUN
admet-169	28	42	.	.	PUNCT
admet-169	29	1	in	in	ADP
admet-169	29	2	addition	addition	NOUN
admet-169	29	3	to	to	ADP
admet-169	29	4	mdr	mdr	PROPN
admet-169	29	5	,	,	PUNCT
admet-169	29	6	barriers	barrier	NOUN
admet-169	29	7	to	to	ADP
admet-169	29	8	oral	oral	ADJ
admet-169	29	9	chemotherapy	chemotherapy	NOUN
admet-169	29	10	are	be	AUX
admet-169	29	11	the	the	DET
admet-169	29	12	intestinal	intestinal	ADJ
admet-169	29	13	drug	drug	NOUN
admet-169	29	14	permeability	permeability	NOUN
admet-169	29	15	uptake	uptake	ADJ
admet-169	29	16	through	through	ADP
admet-169	29	17	epithelial	epithelial	ADJ
admet-169	29	18	cells	cell	NOUN
admet-169	29	19	of	of	ADP
admet-169	29	20	the	the	DET
admet-169	29	21	inner	inner	ADJ
admet-169	29	22	intestinal	intestinal	ADJ
admet-169	29	23	wall	wall	NOUN
admet-169	29	24	,	,	PUNCT
admet-169	29	25	metabolism	metabolism	NOUN
admet-169	29	26	in	in	ADP
admet-169	29	27	the	the	DET
admet-169	29	28	liver	liver	NOUN
admet-169	29	29	and	and	CCONJ
admet-169	29	30	enzymatic	enzymatic	ADJ
admet-169	29	31	degradation	degradation	NOUN
admet-169	29	32	in	in	ADP
admet-169	29	33	the	the	DET
admet-169	29	34	intestinal	intestinal	ADJ
admet-169	29	35	tract	tract	NOUN
admet-169	29	36	[	[	X
admet-169	29	37	16	16	NUM
admet-169	29	38	]	]	PUNCT
admet-169	29	39	.	.	PUNCT
admet-169	30	1	the	the	DET
admet-169	30	2	overall	overall	ADJ
admet-169	30	3	prediction	prediction	NOUN
admet-169	30	4	of	of	ADP
admet-169	30	5	efficacy	efficacy	NOUN
admet-169	30	6	of	of	ADP
admet-169	30	7	an	an	DET
admet-169	30	8	oral	oral	ADJ
admet-169	30	9	based	base	VERB
admet-169	30	10	treatment	treatment	NOUN
admet-169	30	11	is	be	AUX
admet-169	30	12	possible	possible	ADJ
admet-169	30	13	by	by	ADP
admet-169	30	14	using	use	VERB
admet-169	30	15	an	an	DET
admet-169	30	16	appropriate	appropriate	ADJ
admet-169	30	17	model	model	NOUN
admet-169	30	18	system	system	NOUN
admet-169	30	19	in	in	ADP
admet-169	30	20	vitro	vitro	X
admet-169	30	21	[	[	X
admet-169	30	22	17	17	NUM
admet-169	30	23	]	]	PUNCT
admet-169	30	24	.	.	PUNCT
admet-169	31	1	an	an	DET
admet-169	31	2	ideal	ideal	ADJ
admet-169	31	3	model	model	NOUN
admet-169	31	4	system	system	NOUN
admet-169	31	5	for	for	ADP
admet-169	31	6	intestinal	intestinal	ADJ
admet-169	31	7	absorption	absorption	NOUN
admet-169	31	8	is	be	AUX
admet-169	31	9	based	base	VERB
admet-169	31	10	on	on	ADP
admet-169	31	11	the	the	DET
admet-169	31	12	growth	growth	NOUN
admet-169	31	13	of	of	ADP
admet-169	31	14	a	a	DET
admet-169	31	15	cellular	cellular	ADJ
admet-169	31	16	monolayer	monolayer	NOUN
admet-169	31	17	and	and	CCONJ
admet-169	31	18	the	the	DET
admet-169	31	19	careful	careful	ADJ
admet-169	31	20	comparison	comparison	NOUN
admet-169	31	21	of	of	ADP
admet-169	31	22	the	the	DET
admet-169	31	23	drug	drug	NOUN
admet-169	31	24	transport	transport	NOUN
admet-169	31	25	across	across	ADP
admet-169	31	26	this	this	DET
admet-169	31	27	barrier	barrier	NOUN
admet-169	31	28	.	.	PUNCT
admet-169	32	1	this	this	DET
admet-169	32	2	system	system	NOUN
admet-169	32	3	is	be	AUX
admet-169	32	4	referred	refer	VERB
admet-169	32	5	to	to	ADP
admet-169	32	6	as	as	ADP
admet-169	32	7	a	a	DET
admet-169	32	8	transwell	transwell	NOUN
admet-169	32	9	system	system	NOUN
admet-169	32	10	and	and	CCONJ
admet-169	32	11	consists	consist	VERB
admet-169	32	12	of	of	ADP
admet-169	32	13	a	a	DET
admet-169	32	14	donor	donor	NOUN
admet-169	32	15	,	,	PUNCT
admet-169	32	16	receiver	receiver	ADJ
admet-169	32	17	and	and	CCONJ
admet-169	32	18	cellular	cellular	ADJ
admet-169	32	19	compartment	compartment	NOUN
admet-169	32	20	.	.	PUNCT
admet-169	33	1	figure	figure	NOUN
admet-169	33	2	2	2	NUM
admet-169	33	3	illustrates	illustrate	VERB
admet-169	33	4	the	the	DET
admet-169	33	5	schematic	schematic	ADJ
admet-169	33	6	diagram	diagram	NOUN
admet-169	33	7	of	of	ADP
admet-169	33	8	a	a	DET
admet-169	33	9	compartmental	compartmental	ADJ
admet-169	33	10	model	model	NOUN
admet-169	33	11	and	and	CCONJ
admet-169	33	12	working	working	NOUN
admet-169	33	13	model	model	NOUN
admet-169	33	14	of	of	ADP
admet-169	33	15	a	a	DET
admet-169	33	16	transwell	transwell	NOUN
admet-169	33	17	system	system	NOUN
admet-169	33	18	.	.	PUNCT
admet-169	34	1	transport	transport	NOUN
admet-169	34	2	processes	process	NOUN
admet-169	34	3	can	can	AUX
admet-169	34	4	occur	occur	VERB
admet-169	34	5	with	with	ADP
admet-169	34	6	both	both	CCONJ
admet-169	34	7	a	a	DET
admet-169	34	8	unidirectional	unidirectional	ADJ
admet-169	34	9	and/or	and/or	CCONJ
admet-169	34	10	a	a	DET
admet-169	34	11	bi	bi	ADJ
admet-169	34	12	-	-	ADJ
admet-169	34	13	directional	directional	ADJ
admet-169	34	14	mechanism	mechanism	NOUN
admet-169	34	15	of	of	ADP
admet-169	34	16	either	either	CCONJ
admet-169	34	17	active	active	ADJ
admet-169	34	18	transport	transport	NOUN
admet-169	34	19	by	by	ADP
admet-169	34	20	a	a	DET
admet-169	34	21	receptor	receptor	NOUN
admet-169	34	22	based	base	VERB
admet-169	34	23	protein	protein	NOUN
admet-169	34	24	system	system	NOUN
admet-169	34	25	or	or	CCONJ
admet-169	34	26	by	by	ADP
admet-169	34	27	passive	passive	ADJ
admet-169	34	28	diffusion	diffusion	NOUN
admet-169	34	29	along	along	ADP
admet-169	34	30	a	a	DET
admet-169	34	31	concentration	concentration	NOUN
admet-169	34	32	gradient	gradient	NOUN
admet-169	34	33	[	[	X
admet-169	34	34	18	18	NUM
admet-169	34	35	]	]	PUNCT
admet-169	34	36	.	.	PUNCT
admet-169	35	1	active	active	ADJ
admet-169	35	2	transport	transport	NOUN
admet-169	35	3	requires	require	VERB
admet-169	35	4	energy	energy	NOUN
admet-169	35	5	(	(	PUNCT
admet-169	35	6	atp	atp	PROPN
admet-169	35	7	dependent	dependent	ADJ
admet-169	35	8	)	)	PUNCT
admet-169	35	9	and	and	CCONJ
admet-169	35	10	can	can	AUX
admet-169	35	11	be	be	AUX
admet-169	35	12	against	against	ADP
admet-169	35	13	a	a	DET
admet-169	35	14	concentration	concentration	NOUN
admet-169	35	15	gradient	gradient	NOUN
admet-169	35	16	,	,	PUNCT
admet-169	35	17	it	it	PRON
admet-169	35	18	plays	play	VERB
admet-169	35	19	a	a	DET
admet-169	35	20	major	major	ADJ
admet-169	35	21	role	role	NOUN
admet-169	35	22	in	in	ADP
admet-169	35	23	the	the	DET
admet-169	35	24	uptake	uptake	NOUN
admet-169	35	25	of	of	ADP
admet-169	35	26	hydrophilic	hydrophilic	ADJ
admet-169	35	27	compounds	compound	NOUN
admet-169	35	28	into	into	ADP
admet-169	35	29	the	the	DET
admet-169	35	30	cell	cell	NOUN
admet-169	35	31	and	and	CCONJ
admet-169	35	32	in	in	ADP
admet-169	35	33	the	the	DET
admet-169	35	34	efflux	efflux	NOUN
admet-169	35	35	of	of	ADP
admet-169	35	36	drug	drug	NOUN
admet-169	35	37	out	out	ADP
admet-169	35	38	of	of	ADP
admet-169	35	39	the	the	DET
admet-169	35	40	cell	cell	NOUN
admet-169	35	41	.	.	PUNCT
admet-169	36	1	passive	passive	ADJ
admet-169	36	2	diffusion	diffusion	NOUN
admet-169	36	3	from	from	ADP
admet-169	36	4	higher	high	ADJ
admet-169	36	5	to	to	ADP
admet-169	36	6	lower	low	ADJ
admet-169	36	7	concentration	concentration	NOUN
admet-169	36	8	is	be	AUX
admet-169	36	9	atp	atp	NOUN
admet-169	36	10	independent	independent	ADJ
admet-169	36	11	and	and	CCONJ
admet-169	36	12	occurs	occur	VERB
admet-169	36	13	through	through	ADP
admet-169	36	14	lateral	lateral	ADJ
admet-169	36	15	diffusion	diffusion	NOUN
admet-169	36	16	,	,	PUNCT
admet-169	36	17	transcellular	transcellular	NOUN
admet-169	36	18	or	or	CCONJ
admet-169	36	19	paracellular	paracellular	ADJ
admet-169	36	20	pathway	pathway	NOUN
admet-169	36	21	[	[	X
admet-169	36	22	18	18	NUM
admet-169	36	23	]	]	PUNCT
admet-169	36	24	.	.	PUNCT
admet-169	37	1	admet	admet	PROPN
admet-169	37	2	&	&	CCONJ
admet-169	37	3	dmpk	dmpk	PROPN
admet-169	37	4	3(1	3(1	NUM
admet-169	37	5	)	)	PUNCT
admet-169	37	6	(	(	PUNCT
admet-169	37	7	2015	2015	NUM
admet-169	37	8	)	)	PUNCT
admet-169	37	9	51	51	NUM
admet-169	37	10	-	-	SYM
admet-169	37	11	67	67	NUM
admet-169	37	12	adaptation	adaptation	NOUN
admet-169	37	13	of	of	ADP
admet-169	37	14	human	human	ADJ
admet-169	37	15	gut	gut	NOUN
admet-169	37	16	epithelial	epithelial	ADJ
admet-169	37	17	model	model	NOUN
admet-169	37	18	doi	doi	NOUN
admet-169	37	19	:	:	PUNCT
admet-169	37	20	10.5599	10.5599	NUM
admet-169	37	21	/	/	SYM
admet-169	37	22	admet.3.1.169	admet.3.1.169	PROPN
admet-169	37	23	53	53	NUM
admet-169	37	24	figure	figure	NOUN
admet-169	37	25	2	2	NUM
admet-169	37	26	.	.	PUNCT
admet-169	37	27	schematic	schematic	ADJ
admet-169	37	28	diagram	diagram	NOUN
admet-169	37	29	of	of	ADP
admet-169	37	30	caco-2	caco-2	NUM
admet-169	37	31	cell	cell	NOUN
admet-169	37	32	monolayer	monolayer	NOUN
admet-169	37	33	and	and	CCONJ
admet-169	37	34	drug	drug	NOUN
admet-169	37	35	transport	transport	NOUN
admet-169	37	36	processes	process	NOUN
admet-169	37	37	in	in	ADP
admet-169	37	38	the	the	DET
admet-169	37	39	transwell	transwell	NOUN
admet-169	37	40	system	system	NOUN
admet-169	37	41	.	.	PUNCT
admet-169	38	1	apical	apical	ADJ
admet-169	38	2	side	side	NOUN
admet-169	38	3	represents	represent	VERB
admet-169	38	4	the	the	DET
admet-169	38	5	luminal	luminal	ADJ
admet-169	38	6	side	side	NOUN
admet-169	38	7	of	of	ADP
admet-169	38	8	the	the	DET
admet-169	38	9	enterocyte	enterocyte	NOUN
admet-169	38	10	and	and	CCONJ
admet-169	38	11	basolateral	basolateral	ADJ
admet-169	38	12	side	side	NOUN
admet-169	38	13	represents	represent	VERB
admet-169	38	14	the	the	DET
admet-169	38	15	blood	blood	NOUN
admet-169	38	16	circulation	circulation	NOUN
admet-169	38	17	.	.	PUNCT
admet-169	39	1	the	the	DET
admet-169	39	2	dashed	dash	VERB
admet-169	39	3	arrow	arrow	NOUN
admet-169	39	4	describes	describe	VERB
admet-169	39	5	drug	drug	NOUN
admet-169	39	6	uptake	uptake	ADJ
admet-169	39	7	from	from	ADP
admet-169	39	8	the	the	DET
admet-169	39	9	apical	apical	ADJ
admet-169	39	10	to	to	ADP
admet-169	39	11	the	the	DET
admet-169	39	12	basolateral	basolateral	ADJ
admet-169	39	13	side	side	NOUN
admet-169	39	14	where	where	SCONJ
admet-169	39	15	the	the	DET
admet-169	39	16	apical	apical	ADJ
admet-169	39	17	side	side	NOUN
admet-169	39	18	serves	serve	VERB
admet-169	39	19	as	as	ADP
admet-169	39	20	donor	donor	NOUN
admet-169	39	21	compartment	compartment	NOUN
admet-169	39	22	and	and	CCONJ
admet-169	39	23	basolateral	basolateral	ADJ
admet-169	39	24	side	side	NOUN
admet-169	39	25	serves	serve	VERB
admet-169	39	26	as	as	ADP
admet-169	39	27	receiver	receiver	ADJ
admet-169	39	28	compartment	compartment	NOUN
admet-169	39	29	.	.	PUNCT
admet-169	40	1	single	single	ADJ
admet-169	40	2	headed	head	VERB
admet-169	40	3	arrows	arrow	NOUN
admet-169	40	4	in	in	ADP
admet-169	40	5	the	the	DET
admet-169	40	6	transport	transport	NOUN
admet-169	40	7	processes	process	NOUN
admet-169	40	8	between	between	ADP
admet-169	40	9	compartments	compartment	NOUN
admet-169	40	10	describe	describe	VERB
admet-169	40	11	unidirectional	unidirectional	ADJ
admet-169	40	12	processes	process	NOUN
admet-169	40	13	while	while	SCONJ
admet-169	40	14	the	the	DET
admet-169	40	15	double	double	ADJ
admet-169	40	16	-	-	PUNCT
admet-169	40	17	headed	head	VERB
admet-169	40	18	arrows	arrow	NOUN
admet-169	40	19	describe	describe	VERB
admet-169	40	20	bidirectional	bidirectional	ADJ
admet-169	40	21	processes	process	NOUN
admet-169	40	22	.	.	PUNCT
admet-169	41	1	drug	drug	NOUN
admet-169	41	2	transport	transport	NOUN
admet-169	41	3	between	between	ADP
admet-169	41	4	cellular	cellular	ADJ
admet-169	41	5	compartments	compartment	NOUN
admet-169	41	6	involves	involve	VERB
admet-169	41	7	bidirectional	bidirectional	ADJ
admet-169	41	8	processes	process	NOUN
admet-169	41	9	.	.	PUNCT
admet-169	42	1	a	a	DET
admet-169	42	2	widely	widely	ADV
admet-169	42	3	used	use	VERB
admet-169	42	4	model	model	NOUN
admet-169	42	5	system	system	NOUN
admet-169	42	6	consisting	consist	VERB
admet-169	42	7	of	of	ADP
admet-169	42	8	a	a	DET
admet-169	42	9	caco-2	caco-2	NUM
admet-169	42	10	cell	cell	NOUN
admet-169	42	11	monolayer	monolayer	NOUN
admet-169	42	12	,	,	PUNCT
admet-169	42	13	which	which	PRON
admet-169	42	14	is	be	AUX
admet-169	42	15	a	a	DET
admet-169	42	16	polarized	polarize	VERB
admet-169	42	17	cell	cell	NOUN
admet-169	42	18	line	line	NOUN
admet-169	42	19	derived	derive	VERB
admet-169	42	20	from	from	ADP
admet-169	42	21	human	human	ADJ
admet-169	42	22	epithelial	epithelial	ADJ
admet-169	42	23	colorectal	colorectal	ADJ
admet-169	42	24	adenocarcinoma	adenocarcinoma	NOUN
admet-169	42	25	cells	cell	NOUN
admet-169	42	26	[	[	X
admet-169	42	27	19	19	NUM
admet-169	42	28	]	]	PUNCT
admet-169	42	29	.	.	PUNCT
admet-169	43	1	when	when	SCONJ
admet-169	43	2	cultured	cultured	ADJ
admet-169	43	3	as	as	ADP
admet-169	43	4	a	a	DET
admet-169	43	5	monolayer	monolayer	NOUN
admet-169	43	6	(	(	PUNCT
admet-169	43	7	in	in	ADP
admet-169	43	8	vitro	vitro	X
admet-169	43	9	)	)	PUNCT
admet-169	43	10	,	,	PUNCT
admet-169	43	11	this	this	DET
admet-169	43	12	cell	cell	NOUN
admet-169	43	13	line	line	NOUN
admet-169	43	14	demonstrates	demonstrate	VERB
admet-169	43	15	the	the	DET
admet-169	43	16	same	same	ADJ
admet-169	43	17	phenotype	phenotype	NOUN
admet-169	43	18	,	,	PUNCT
admet-169	43	19	morphology	morphology	NOUN
admet-169	43	20	and	and	CCONJ
admet-169	43	21	functions	function	NOUN
admet-169	43	22	as	as	ADP
admet-169	43	23	enterocytes	enterocyte	NOUN
admet-169	43	24	of	of	ADP
admet-169	43	25	the	the	DET
admet-169	43	26	small	small	ADJ
admet-169	43	27	intestine	intestine	NOUN
admet-169	43	28	[	[	PUNCT
admet-169	43	29	20	20	NUM
admet-169	43	30	-	-	SYM
admet-169	43	31	23	23	NUM
admet-169	43	32	]	]	PUNCT
admet-169	43	33	.	.	PUNCT
admet-169	44	1	since	since	SCONJ
admet-169	44	2	this	this	DET
admet-169	44	3	cell	cell	NOUN
admet-169	44	4	line	line	NOUN
admet-169	44	5	expresses	express	VERB
admet-169	44	6	the	the	DET
admet-169	44	7	same	same	ADJ
admet-169	44	8	enzymes	enzyme	NOUN
admet-169	44	9	and	and	CCONJ
admet-169	44	10	transport	transport	NOUN
admet-169	44	11	proteins	protein	NOUN
admet-169	44	12	that	that	PRON
admet-169	44	13	mediate	mediate	VERB
admet-169	44	14	drug	drug	NOUN
admet-169	44	15	uptake	uptake	NOUN
admet-169	44	16	or	or	CCONJ
admet-169	44	17	efflux	efflux	VERB
admet-169	44	18	in	in	ADP
admet-169	44	19	the	the	DET
admet-169	44	20	intestine	intestine	NOUN
admet-169	44	21	,	,	PUNCT
admet-169	44	22	it	it	PRON
admet-169	44	23	is	be	AUX
admet-169	44	24	possible	possible	ADJ
admet-169	44	25	to	to	PART
admet-169	44	26	determine	determine	VERB
admet-169	44	27	significant	significant	ADJ
admet-169	44	28	correlation	correlation	NOUN
admet-169	44	29	between	between	ADP
admet-169	44	30	permeability	permeability	NOUN
admet-169	44	31	of	of	ADP
admet-169	44	32	compounds	compound	NOUN
admet-169	44	33	under	under	ADP
admet-169	44	34	in	in	ADP
admet-169	44	35	vivo	vivo	ADJ
admet-169	44	36	conditions	condition	NOUN
admet-169	44	37	[	[	X
admet-169	44	38	23	23	NUM
admet-169	44	39	]	]	PUNCT
admet-169	44	40	.	.	PUNCT
admet-169	45	1	the	the	DET
admet-169	45	2	transwell	transwell	NOUN
admet-169	45	3	system	system	NOUN
admet-169	45	4	has	have	AUX
admet-169	45	5	become	become	VERB
admet-169	45	6	the	the	DET
admet-169	45	7	standard	standard	ADJ
admet-169	45	8	model	model	NOUN
admet-169	45	9	to	to	PART
admet-169	45	10	test	test	VERB
admet-169	45	11	the	the	DET
admet-169	45	12	drug	drug	NOUN
admet-169	45	13	permeability	permeability	NOUN
admet-169	45	14	and	and	CCONJ
admet-169	45	15	uptake	uptake	NOUN
admet-169	45	16	of	of	ADP
admet-169	45	17	orally	orally	ADV
admet-169	45	18	administered	administer	VERB
admet-169	45	19	compounds	compound	NOUN
admet-169	45	20	[	[	X
admet-169	45	21	17	17	NUM
admet-169	45	22	]	]	PUNCT
admet-169	45	23	.	.	PUNCT
admet-169	46	1	caco-2	caco-2	NUM
admet-169	46	2	cell	cell	NOUN
admet-169	46	3	monolayers	monolayer	NOUN
admet-169	46	4	enable	enable	VERB
admet-169	46	5	investigation	investigation	NOUN
admet-169	46	6	into	into	ADP
admet-169	46	7	the	the	DET
admet-169	46	8	absorption	absorption	NOUN
admet-169	46	9	of	of	ADP
admet-169	46	10	drugs	drug	NOUN
admet-169	46	11	,	,	PUNCT
admet-169	46	12	the	the	DET
admet-169	46	13	passive	passive	ADJ
admet-169	46	14	and	and	CCONJ
admet-169	46	15	the	the	DET
admet-169	46	16	active	active	ADJ
admet-169	46	17	transport	transport	NOUN
admet-169	46	18	systems	system	NOUN
admet-169	46	19	of	of	ADP
admet-169	46	20	its	its	PRON
admet-169	46	21	transport	transport	NOUN
admet-169	46	22	processes	process	NOUN
admet-169	46	23	across	across	ADP
admet-169	46	24	a	a	DET
admet-169	46	25	barrier	barrier	NOUN
admet-169	46	26	directly	directly	ADV
admet-169	46	27	comparable	comparable	ADJ
admet-169	46	28	to	to	ADP
admet-169	46	29	the	the	DET
admet-169	46	30	human	human	ADJ
admet-169	46	31	system	system	NOUN
admet-169	46	32	.	.	PUNCT
admet-169	47	1	a	a	DET
admet-169	47	2	disadvantage	disadvantage	NOUN
admet-169	47	3	of	of	ADP
admet-169	47	4	this	this	DET
admet-169	47	5	model	model	NOUN
admet-169	47	6	system	system	NOUN
admet-169	47	7	is	be	AUX
admet-169	47	8	the	the	DET
admet-169	47	9	standard	standard	ADJ
admet-169	47	10	21	21	NUM
admet-169	47	11	day	day	NOUN
admet-169	47	12	protocol	protocol	NOUN
admet-169	47	13	for	for	ADP
admet-169	47	14	the	the	DET
admet-169	47	15	formation	formation	NOUN
admet-169	47	16	of	of	ADP
admet-169	47	17	the	the	DET
admet-169	47	18	caco2	caco2	NOUN
admet-169	47	19	monolayer	monolayer	NOUN
admet-169	47	20	[	[	X
admet-169	47	21	23	23	NUM
admet-169	47	22	]	]	PUNCT
admet-169	47	23	.	.	PUNCT
admet-169	48	1	an	an	DET
admet-169	48	2	alternative	alternative	ADJ
admet-169	48	3	3	3	NUM
admet-169	48	4	-	-	PUNCT
admet-169	48	5	day	day	NOUN
admet-169	48	6	culture	culture	NOUN
admet-169	48	7	system	system	NOUN
admet-169	48	8	offers	offer	VERB
admet-169	48	9	a	a	DET
admet-169	48	10	more	more	ADV
admet-169	48	11	convenient	convenient	ADJ
admet-169	48	12	and	and	CCONJ
admet-169	48	13	productive	productive	ADJ
admet-169	48	14	alternative	alternative	NOUN
admet-169	48	15	that	that	PRON
admet-169	48	16	has	have	AUX
admet-169	48	17	been	be	AUX
admet-169	48	18	demonstrated	demonstrate	VERB
admet-169	48	19	to	to	PART
admet-169	48	20	provide	provide	VERB
admet-169	48	21	comparable	comparable	ADJ
admet-169	48	22	results	result	NOUN
admet-169	48	23	to	to	ADP
admet-169	48	24	the	the	DET
admet-169	48	25	standard	standard	ADJ
admet-169	48	26	system	system	NOUN
admet-169	48	27	[	[	X
admet-169	48	28	24	24	NUM
admet-169	48	29	]	]	PUNCT
admet-169	48	30	.	.	PUNCT
admet-169	49	1	we	we	PRON
admet-169	49	2	optimized	optimize	VERB
admet-169	49	3	this	this	DET
admet-169	49	4	model	model	NOUN
admet-169	49	5	to	to	PART
admet-169	49	6	investigate	investigate	VERB
admet-169	49	7	the	the	DET
admet-169	49	8	absorption	absorption	NOUN
admet-169	49	9	,	,	PUNCT
admet-169	49	10	efflux	efflux	NOUN
admet-169	49	11	and	and	CCONJ
admet-169	49	12	transport	transport	NOUN
admet-169	49	13	properties	property	NOUN
admet-169	49	14	of	of	ADP
admet-169	49	15	two	two	NUM
admet-169	49	16	tkis	tki	NOUN
admet-169	49	17	,	,	PUNCT
admet-169	49	18	namely	namely	ADV
admet-169	49	19	erlotinib	erlotinib	NOUN
admet-169	49	20	and	and	CCONJ
admet-169	49	21	gefitinib	gefitinib	NOUN
admet-169	49	22	,	,	PUNCT
admet-169	49	23	utilizing	utilize	VERB
admet-169	49	24	lc	lc	NOUN
admet-169	49	25	-	-	PUNCT
admet-169	49	26	msms	msm	NOUN
admet-169	49	27	sensitivity	sensitivity	NOUN
admet-169	49	28	to	to	PART
admet-169	49	29	reliably	reliably	ADV
admet-169	49	30	measure	measure	VERB
admet-169	49	31	the	the	DET
admet-169	49	32	individual	individual	ADJ
admet-169	49	33	compound	compound	NOUN
admet-169	49	34	levels	level	NOUN
admet-169	49	35	[	[	X
admet-169	49	36	25	25	NUM
admet-169	49	37	]	]	PUNCT
admet-169	49	38	.	.	PUNCT
admet-169	50	1	experimental	experimental	ADJ
admet-169	50	2	materials	material	NOUN
admet-169	50	3	erlotinib	erlotinib	NOUN
admet-169	50	4	and	and	CCONJ
admet-169	50	5	gefitinib	gefitinib	NOUN
admet-169	50	6	were	be	AUX
admet-169	50	7	purchased	purchase	VERB
admet-169	50	8	from	from	ADP
admet-169	50	9	lc	lc	NOUN
admet-169	50	10	laboratories	laboratory	NOUN
admet-169	50	11	(	(	PUNCT
admet-169	50	12	woburn	woburn	PROPN
admet-169	50	13	,	,	PUNCT
admet-169	50	14	ma	ma	PROPN
admet-169	50	15	,	,	PUNCT
admet-169	50	16	usa	usa	PROPN
admet-169	50	17	)	)	PUNCT
admet-169	50	18	.	.	PUNCT
admet-169	51	1	all	all	DET
admet-169	51	2	general	general	ADJ
admet-169	51	3	reagents	reagent	NOUN
admet-169	51	4	were	be	AUX
admet-169	51	5	purchased	purchase	VERB
admet-169	51	6	from	from	ADP
admet-169	51	7	sigma	sigma	PROPN
admet-169	51	8	(	(	PUNCT
admet-169	51	9	zwijndrecht	zwijndrecht	NOUN
admet-169	51	10	,	,	PUNCT
admet-169	51	11	the	the	DET
admet-169	51	12	netherlands	netherlands	PROPN
admet-169	51	13	)	)	PUNCT
admet-169	51	14	.	.	PUNCT
admet-169	52	1	ko143	ko143	PROPN
admet-169	52	2	was	be	AUX
admet-169	52	3	a	a	DET
admet-169	52	4	kind	kind	ADJ
admet-169	52	5	gift	gift	NOUN
admet-169	52	6	of	of	ADP
admet-169	52	7	professor	professor	NOUN
admet-169	52	8	gj	gj	PROPN
admet-169	52	9	koomen	koomen	PROPN
admet-169	52	10	,	,	PUNCT
admet-169	52	11	university	university	NOUN
admet-169	52	12	of	of	ADP
admet-169	52	13	amsterdam	amsterdam	PROPN
admet-169	52	14	,	,	PUNCT
admet-169	52	15	the	the	DET
admet-169	52	16	netherlands	netherlands	PROPN
admet-169	52	17	.	.	PUNCT
admet-169	53	1	fetal	fetal	ADJ
admet-169	53	2	bovine	bovine	NOUN
admet-169	53	3	serum	serum	NOUN
admet-169	53	4	(	(	PUNCT
admet-169	53	5	fbs	fbs	PROPN
admet-169	53	6	)	)	PUNCT
admet-169	53	7	was	be	AUX
admet-169	53	8	purchased	purchase	VERB
admet-169	53	9	from	from	ADP
admet-169	53	10	paa	paa	PROPN
admet-169	53	11	laboratories	laboratory	NOUN
admet-169	53	12	gmbh	gmbh	PROPN
admet-169	53	13	(	(	PUNCT
admet-169	53	14	pasching	pasching	NOUN
admet-169	53	15	,	,	PUNCT
admet-169	53	16	austria	austria	PROPN
admet-169	53	17	)	)	PUNCT
admet-169	53	18	while	while	SCONJ
admet-169	53	19	the	the	DET
admet-169	53	20	bovine	bovine	NOUN
admet-169	53	21	serum	serum	NOUN
admet-169	53	22	albumin	albumin	PROPN
admet-169	53	23	(	(	PUNCT
admet-169	53	24	bsa	bsa	PROPN
admet-169	53	25	)	)	PUNCT
admet-169	53	26	fraction	fraction	NOUN
admet-169	53	27	v	v	NOUN
admet-169	53	28	was	be	AUX
admet-169	53	29	purchased	purchase	VERB
admet-169	53	30	from	from	ADP
admet-169	53	31	roche	roche	PROPN
admet-169	53	32	diagnostics	diagnostic	NOUN
admet-169	53	33	(	(	PUNCT
admet-169	53	34	mannheim	mannheim	PROPN
admet-169	53	35	,	,	PUNCT
admet-169	53	36	germany	germany	PROPN
admet-169	53	37	)	)	PUNCT
admet-169	53	38	.	.	PUNCT
admet-169	54	1	roswell	roswell	PROPN
admet-169	54	2	park	park	PROPN
admet-169	54	3	memorial	memorial	PROPN
admet-169	54	4	institute	institute	PROPN
admet-169	54	5	(	(	PUNCT
admet-169	54	6	rpmi	rpmi	NOUN
admet-169	54	7	)	)	PUNCT
admet-169	54	8	640	640	NUM
admet-169	54	9	medium	medium	NOUN
admet-169	54	10	,	,	PUNCT
admet-169	54	11	trypsin-­edta	trypsin-­edta	ADP
admet-169	54	12	,	,	PUNCT
admet-169	54	13	penicillin	penicillin	NOUN
admet-169	54	14	,	,	PUNCT
admet-169	54	15	streptomycin	streptomycin	PROPN
admet-169	54	16	(	(	PUNCT
admet-169	54	17	10000	10000	NUM
admet-169	54	18	u	u	NOUN
admet-169	54	19	/	/	SYM
admet-169	54	20	ml	ml	NOUN
admet-169	54	21	)	)	PUNCT
admet-169	54	22	and	and	CCONJ
admet-169	54	23	1	1	NUM
admet-169	54	24	m	m	NOUN
admet-169	54	25	hepes	hepe	NOUN
admet-169	54	26	buffer	buffer	NOUN
admet-169	54	27	(	(	PUNCT
admet-169	54	28	in	in	ADP
admet-169	54	29	0.85	0.85	NUM
admet-169	54	30	%	%	NOUN
admet-169	54	31	nacl	nacl	NOUN
admet-169	54	32	)	)	PUNCT
admet-169	54	33	were	be	AUX
admet-169	54	34	purchased	purchase	VERB
admet-169	54	35	from	from	ADP
admet-169	54	36	lonza	lonza	PROPN
admet-169	54	37	benelux	benelux	PROPN
admet-169	54	38	bv	bv	PROPN
admet-169	54	39	(	(	PUNCT
admet-169	54	40	breda	breda	PROPN
admet-169	54	41	,	,	PUNCT
admet-169	54	42	nl	nl	PROPN
admet-169	54	43	)	)	PUNCT
admet-169	54	44	.	.	PUNCT
admet-169	55	1	hank	hank	PROPN
admet-169	55	2	’s	’s	PART
admet-169	55	3	balanced	balanced	ADJ
admet-169	55	4	salt	salt	NOUN
admet-169	55	5	peters	peters	PROPN
admet-169	55	6	et	et	PROPN
admet-169	55	7	al	al	PROPN
admet-169	55	8	.	.	PROPN
admet-169	55	9	admet	admet	PROPN
admet-169	55	10	&	&	CCONJ
admet-169	55	11	dmpk	dmpk	PROPN
admet-169	55	12	3(1	3(1	NUM
admet-169	55	13	)	)	PUNCT
admet-169	55	14	(	(	PUNCT
admet-169	55	15	2015	2015	NUM
admet-169	55	16	)	)	PUNCT
admet-169	55	17	51	51	NUM
admet-169	55	18	-	-	SYM
admet-169	55	19	67	67	NUM
admet-169	55	20	54	54	NUM
admet-169	55	21	solution	solution	NOUN
admet-169	55	22	(	(	PUNCT
admet-169	55	23	hbss	hbss	NOUN
admet-169	55	24	)	)	PUNCT
admet-169	55	25	containing	contain	VERB
admet-169	55	26	cacl2	cacl2	NOUN
admet-169	55	27	and	and	CCONJ
admet-169	55	28	mgcl2	mgcl2	NOUN
admet-169	55	29	as	as	ADP
admet-169	55	30	the	the	DET
admet-169	55	31	transport	transport	NOUN
admet-169	55	32	medium	medium	NOUN
admet-169	55	33	for	for	ADP
admet-169	55	34	drug	drug	NOUN
admet-169	55	35	transporting	transport	VERB
admet-169	55	36	cross	cross	NOUN
admet-169	55	37	cell	cell	NOUN
admet-169	55	38	monolayer	monolayer	NOUN
admet-169	55	39	was	be	AUX
admet-169	55	40	purchased	purchase	VERB
admet-169	55	41	from	from	ADP
admet-169	55	42	invitrogen	invitrogen	PROPN
admet-169	55	43	(	(	PUNCT
admet-169	55	44	breda	breda	PROPN
admet-169	55	45	,	,	PUNCT
admet-169	55	46	the	the	DET
admet-169	55	47	netherlands	netherlands	PROPN
admet-169	55	48	)	)	PUNCT
admet-169	55	49	.	.	PUNCT
admet-169	56	1	the	the	DET
admet-169	56	2	growth	growth	NOUN
admet-169	56	3	medium	medium	NOUN
admet-169	56	4	(	(	PUNCT
admet-169	56	5	dulbecco	dulbecco	NOUN
admet-169	56	6	’s	’s	PART
admet-169	56	7	modified	modify	VERB
admet-169	56	8	eagle	eagle	PROPN
admet-169	56	9	medium	medium	ADJ
admet-169	56	10	(	(	PUNCT
admet-169	56	11	dmem	dmem	ADJ
admet-169	56	12	)	)	PUNCT
admet-169	56	13	based	base	VERB
admet-169	56	14	)	)	PUNCT
admet-169	56	15	,	,	PUNCT
admet-169	56	16	differentiation	differentiation	NOUN
admet-169	56	17	medium	medium	NOUN
admet-169	56	18	(	(	PUNCT
admet-169	56	19	a	a	DET
admet-169	56	20	serum	serum	NOUN
admet-169	56	21	free	free	ADJ
admet-169	56	22	medium	medium	NOUN
admet-169	56	23	containing	contain	VERB
admet-169	56	24	butyric	butyric	ADJ
admet-169	56	25	acid	acid	NOUN
admet-169	56	26	)	)	PUNCT
admet-169	56	27	to	to	PART
admet-169	56	28	induce	induce	VERB
admet-169	56	29	fully	fully	ADV
admet-169	56	30	differentiation	differentiation	NOUN
admet-169	56	31	to	to	ADP
admet-169	56	32	enterocytes	enterocyte	NOUN
admet-169	56	33	and	and	CCONJ
admet-169	56	34	supplemental	supplemental	ADJ
admet-169	56	35	medium	medium	NOUN
admet-169	56	36	to	to	PART
admet-169	56	37	maintain	maintain	VERB
admet-169	56	38	the	the	DET
admet-169	56	39	cells	cell	NOUN
admet-169	56	40	under	under	ADP
admet-169	56	41	serum	serum	NOUN
admet-169	56	42	free	free	ADJ
admet-169	56	43	condition	condition	NOUN
admet-169	56	44	specific	specific	ADJ
admet-169	56	45	for	for	ADP
admet-169	56	46	caco-2	caco-2	NUM
admet-169	56	47	cell	cell	NOUN
admet-169	56	48	monolayer	monolayer	NOUN
admet-169	56	49	were	be	AUX
admet-169	56	50	purchased	purchase	VERB
admet-169	56	51	from	from	ADP
admet-169	56	52	bd	bd	PROPN
admet-169	56	53	biocoat	biocoat	PROPN
admet-169	56	54	™	™	PROPN
admet-169	56	55	(	(	PUNCT
admet-169	56	56	breda	breda	PROPN
admet-169	56	57	,	,	PUNCT
admet-169	56	58	the	the	DET
admet-169	56	59	netherlands	netherlands	PROPN
admet-169	56	60	)	)	PUNCT
admet-169	56	61	.	.	PUNCT
admet-169	57	1	high	high	ADJ
admet-169	57	2	purity	purity	NOUN
admet-169	57	3	erlotinib	erlotinib	NOUN
admet-169	57	4	and	and	CCONJ
admet-169	57	5	gefitinib	gefitinib	NOUN
admet-169	57	6	was	be	AUX
admet-169	57	7	obtained	obtain	VERB
admet-169	57	8	from	from	ADP
admet-169	57	9	lc	lc	NOUN
admet-169	57	10	-	-	PUNCT
admet-169	57	11	laboratories	laboratory	NOUN
admet-169	57	12	(	(	PUNCT
admet-169	57	13	massachusetts	massachusetts	PROPN
admet-169	57	14	,	,	PUNCT
admet-169	57	15	usa	usa	PROPN
admet-169	57	16	)	)	PUNCT
admet-169	57	17	.	.	PUNCT
admet-169	58	1	analytical	analytical	ADJ
admet-169	58	2	grade	grade	NOUN
admet-169	58	3	solvents	solvent	NOUN
admet-169	58	4	like	like	ADP
admet-169	58	5	acetonitrile	acetonitrile	NOUN
admet-169	58	6	,	,	PUNCT
admet-169	58	7	methanol	methanol	NOUN
admet-169	58	8	and	and	CCONJ
admet-169	58	9	isopropanol	isopropanol	NOUN
admet-169	58	10	were	be	AUX
admet-169	58	11	purchased	purchase	VERB
admet-169	58	12	from	from	ADP
admet-169	58	13	biosolve	biosolve	NOUN
admet-169	58	14	bv	bv	PROPN
admet-169	58	15	(	(	PUNCT
admet-169	58	16	valkenwaard	valkenwaard	PROPN
admet-169	58	17	,	,	PUNCT
admet-169	58	18	nl	nl	PROPN
admet-169	58	19	)	)	PUNCT
admet-169	58	20	.	.	PUNCT
admet-169	59	1	bio­rad	bio­rad	PROPN
admet-169	59	2	protein	protein	NOUN
admet-169	59	3	assay	assay	VERB
admet-169	59	4	was	be	AUX
admet-169	59	5	purchased	purchase	VERB
admet-169	59	6	from	from	ADP
admet-169	59	7	bio-­rad	bio-­rad	PROPN
admet-169	59	8	laboratories	laboratory	NOUN
admet-169	59	9	gmbh	gmbh	PROPN
admet-169	59	10	(	(	PUNCT
admet-169	59	11	münchen	münchen	NOUN
admet-169	59	12	,	,	PUNCT
admet-169	59	13	de	de	NOUN
admet-169	59	14	)	)	PUNCT
admet-169	59	15	.	.	PUNCT
admet-169	60	1	milliq	milliq	PROPN
admet-169	60	2	water	water	NOUN
admet-169	60	3	was	be	AUX
admet-169	60	4	supplied	supply	VERB
admet-169	60	5	via	via	ADP
admet-169	60	6	a	a	DET
admet-169	60	7	milliq	milliq	ADJ
admet-169	60	8	water	water	NOUN
admet-169	60	9	purification	purification	NOUN
admet-169	60	10	system	system	NOUN
admet-169	60	11	(	(	PUNCT
admet-169	60	12	millipore	millipore	PROPN
admet-169	60	13	,	,	PUNCT
admet-169	60	14	nl	nl	PROPN
admet-169	60	15	)	)	PUNCT
admet-169	60	16	.	.	PUNCT
admet-169	61	1	all	all	DET
admet-169	61	2	other	other	ADJ
admet-169	61	3	reagents	reagent	NOUN
admet-169	61	4	were	be	AUX
admet-169	61	5	of	of	ADP
admet-169	61	6	an	an	DET
admet-169	61	7	analytical	analytical	ADJ
admet-169	61	8	grade	grade	NOUN
admet-169	61	9	unless	unless	SCONJ
admet-169	61	10	stated	state	VERB
admet-169	61	11	and	and	CCONJ
admet-169	61	12	sourced	source	VERB
admet-169	61	13	locally	locally	ADV
admet-169	61	14	.	.	PUNCT
admet-169	62	1	equipment	equipment	NOUN
admet-169	62	2	the	the	DET
admet-169	62	3	biocoat	biocoat	PROPN
admet-169	62	4	®	®	NOUN
admet-169	62	5	hts	hts	PROPN
admet-169	62	6	caco­2	caco­2	PROPN
admet-169	62	7	assay	assay	VERB
admet-169	62	8	system	system	NOUN
admet-169	62	9	and	and	CCONJ
admet-169	62	10	bd	bd	PROPN
admet-169	62	11	falcontm	falcontm	ADJ
admet-169	62	12	24	24	NUM
admet-169	62	13	-	-	PUNCT
admet-169	62	14	well	well	NOUN
admet-169	62	15	multiwell	multiwell	ADJ
admet-169	62	16	plates	plate	NOUN
admet-169	62	17	were	be	AUX
admet-169	62	18	purchased	purchase	VERB
admet-169	62	19	from	from	ADP
admet-169	62	20	becton	becton	PROPN
admet-169	62	21	dickinson	dickinson	PROPN
admet-169	62	22	bv	bv	PROPN
admet-169	62	23	(	(	PUNCT
admet-169	62	24	breda	breda	PROPN
admet-169	62	25	,	,	PUNCT
admet-169	62	26	nl	nl	PROPN
admet-169	62	27	)	)	PUNCT
admet-169	62	28	.	.	PUNCT
admet-169	63	1	breathe	breathe	ADJ
admet-169	63	2	-	-	PUNCT
admet-169	63	3	easier	easy	ADJ
admet-169	63	4	microplate	microplate	NOUN
admet-169	63	5	sealing	seal	VERB
admet-169	63	6	film	film	NOUN
admet-169	63	7	was	be	AUX
admet-169	63	8	purchased	purchase	VERB
admet-169	63	9	from	from	ADP
admet-169	63	10	diversified	diversified	ADJ
admet-169	63	11	biotech	biotech	NOUN
admet-169	63	12	bv	bv	PROPN
admet-169	63	13	(	(	PUNCT
admet-169	63	14	ulvenhout	ulvenhout	PROPN
admet-169	63	15	,	,	PUNCT
admet-169	63	16	nl	nl	PROPN
admet-169	63	17	)	)	PUNCT
admet-169	63	18	.	.	PUNCT
admet-169	64	1	the	the	DET
admet-169	64	2	microplate	microplate	PROPN
admet-169	64	3	reader	reader	NOUN
admet-169	64	4	was	be	AUX
admet-169	64	5	provided	provide	VERB
admet-169	64	6	by	by	ADP
admet-169	64	7	tecan	tecan	PROPN
admet-169	64	8	benelux	benelux	PROPN
admet-169	64	9	bvba	bvba	PROPN
admet-169	64	10	(	(	PUNCT
admet-169	64	11	giessen	giessen	PROPN
admet-169	64	12	,	,	PUNCT
admet-169	64	13	nl	nl	PROPN
admet-169	64	14	)	)	PUNCT
admet-169	64	15	and	and	CCONJ
admet-169	64	16	spectra	spectra	ADJ
admet-169	64	17	fluor	fluor	NOUN
admet-169	64	18	software	software	NOUN
admet-169	64	19	(	(	PUNCT
admet-169	64	20	xfluor4	xfluor4	X
admet-169	64	21	version	version	NOUN
admet-169	64	22	v	v	ADP
admet-169	64	23	4.50	4.50	NUM
admet-169	64	24	)	)	PUNCT
admet-169	64	25	was	be	AUX
admet-169	64	26	used	use	VERB
admet-169	64	27	.	.	PUNCT
admet-169	65	1	the	the	DET
admet-169	65	2	trans	trans	PROPN
admet-169	65	3	epithelial	epithelial	ADJ
admet-169	65	4	electrical	electrical	ADJ
admet-169	65	5	resistance	resistance	NOUN
admet-169	65	6	(	(	PUNCT
admet-169	65	7	teer	teer	NOUN
admet-169	65	8	)	)	PUNCT
admet-169	65	9	meter	meter	NOUN
admet-169	65	10	(	(	PUNCT
admet-169	65	11	millicell	millicell	PROPN
admet-169	65	12	®	®	NOUN
admet-169	65	13	–	–	PUNCT
admet-169	65	14	ers	er	NOUN
admet-169	65	15	)	)	PUNCT
admet-169	65	16	was	be	AUX
admet-169	65	17	provided	provide	VERB
admet-169	65	18	by	by	ADP
admet-169	65	19	millipore	millipore	PROPN
admet-169	65	20	(	(	PUNCT
admet-169	65	21	amsterdam	amsterdam	PROPN
admet-169	65	22	,	,	PUNCT
admet-169	65	23	nl	nl	PROPN
admet-169	65	24	)	)	PUNCT
admet-169	65	25	.	.	PUNCT
admet-169	66	1	the	the	DET
admet-169	66	2	liquid	liquid	ADJ
admet-169	66	3	chromatography	chromatography	NOUN
admet-169	66	4	coupled	couple	VERB
admet-169	66	5	to	to	ADP
admet-169	66	6	mass	mass	ADJ
admet-169	66	7	spectrometry	spectrometry	NOUN
admet-169	66	8	(	(	PUNCT
admet-169	66	9	lc	lc	PROPN
admet-169	66	10	-	-	PUNCT
admet-169	66	11	ms	ms	PROPN
admet-169	66	12	/	/	SYM
admet-169	66	13	ms	ms	NOUN
admet-169	66	14	)	)	PUNCT
admet-169	66	15	analyses	analysis	NOUN
admet-169	66	16	were	be	AUX
admet-169	66	17	performed	perform	VERB
admet-169	66	18	using	use	VERB
admet-169	66	19	a	a	DET
admet-169	66	20	dionex	dionex	ADV
admet-169	66	21	ultimate	ultimate	ADJ
admet-169	66	22	3000	3000	NUM
admet-169	66	23	system	system	NOUN
admet-169	66	24	coupled	couple	VERB
admet-169	66	25	with	with	ADP
admet-169	66	26	an	an	DET
admet-169	66	27	api	api	NOUN
admet-169	66	28	3000	3000	NUM
admet-169	66	29	mass	mass	NOUN
admet-169	66	30	spectrometer	spectrometer	NOUN
admet-169	66	31	.	.	PUNCT
admet-169	67	1	for	for	ADP
admet-169	67	2	this	this	DET
admet-169	67	3	system	system	NOUN
admet-169	67	4	the	the	DET
admet-169	67	5	following	follow	VERB
admet-169	67	6	software	software	NOUN
admet-169	67	7	was	be	AUX
admet-169	67	8	used	use	VERB
admet-169	67	9	;	;	PUNCT
admet-169	67	10	analyst	analyst	NOUN
admet-169	67	11	version	version	NOUN
admet-169	67	12	1.5.2	1.5.2	NUM
admet-169	67	13	from	from	ADP
admet-169	67	14	applied	apply	VERB
admet-169	67	15	biosciences	bioscience	NOUN
admet-169	67	16	,	,	PUNCT
admet-169	67	17	in	in	ADP
admet-169	67	18	combination	combination	NOUN
admet-169	67	19	with	with	ADP
admet-169	67	20	dionex	dionex	NOUN
admet-169	67	21	,	,	PUNCT
admet-169	67	22	chromeleon	chromeleon	NOUN
admet-169	67	23	lc	lc	PROPN
admet-169	67	24	modules	module	NOUN
admet-169	67	25	version	version	NOUN
admet-169	67	26	6.8	6.8	NUM
admet-169	67	27	,	,	PUNCT
admet-169	67	28	controlled	control	VERB
admet-169	67	29	by	by	ADP
admet-169	67	30	dionex	dionex	PROPN
admet-169	67	31	mass	mass	PROPN
admet-169	67	32	link	link	NOUN
admet-169	67	33	(	(	PUNCT
admet-169	67	34	dms	dms	NOUN
admet-169	67	35	)	)	PUNCT
admet-169	67	36	version	version	NOUN
admet-169	67	37	2.10	2.10	NUM
admet-169	67	38	.	.	PUNCT
admet-169	68	1	cell	cell	NOUN
admet-169	68	2	culture	culture	NOUN
admet-169	68	3	the	the	DET
admet-169	68	4	transwell	transwell	NOUN
admet-169	68	5	system	system	NOUN
admet-169	68	6	was	be	AUX
admet-169	68	7	developed	develop	VERB
admet-169	68	8	using	use	VERB
admet-169	68	9	the	the	DET
admet-169	68	10	wild	wild	ADJ
admet-169	68	11	type	type	NOUN
admet-169	68	12	caco-2	caco-2	NUM
admet-169	68	13	cell	cell	NOUN
admet-169	68	14	line	line	NOUN
admet-169	68	15	(	(	PUNCT
admet-169	68	16	passage	passage	NOUN
admet-169	68	17	15	15	NUM
admet-169	68	18	–	–	SYM
admet-169	68	19	25	25	NUM
admet-169	68	20	)	)	PUNCT
admet-169	68	21	after	after	ADP
admet-169	68	22	defrost	defrost	NOUN
admet-169	68	23	.	.	PUNCT
admet-169	69	1	cells	cell	NOUN
admet-169	69	2	were	be	AUX
admet-169	69	3	cultured	culture	VERB
admet-169	69	4	routinely	routinely	ADV
admet-169	69	5	in	in	ADP
admet-169	69	6	dmem	dmem	NOUN
admet-169	69	7	containing	contain	VERB
admet-169	69	8	4.5	4.5	NUM
admet-169	69	9	g/	g/	NOUN
admet-169	69	10	liter	liter	NOUN
admet-169	69	11	glucose	glucose	NOUN
admet-169	69	12	and	and	CCONJ
admet-169	69	13	l	l	NOUN
admet-169	69	14	-	-	NOUN
admet-169	69	15	glutamine	glutamine	NOUN
admet-169	69	16	supplemented	supplement	VERB
admet-169	69	17	with	with	ADP
admet-169	69	18	10	10	NUM
admet-169	69	19	%	%	NOUN
admet-169	69	20	fbs	fbs	ADJ
admet-169	69	21	and	and	CCONJ
admet-169	69	22	20	20	NUM
admet-169	69	23	mm	mm	NOUN
admet-169	69	24	of	of	ADP
admet-169	69	25	hepes	hepe	NOUN
admet-169	69	26	at	at	ADP
admet-169	69	27	standard	standard	ADJ
admet-169	69	28	conditions	condition	NOUN
admet-169	69	29	of	of	ADP
admet-169	69	30	37	37	NUM
admet-169	69	31	°	°	NOUN
admet-169	69	32	c	c	NOUN
admet-169	69	33	,	,	PUNCT
admet-169	69	34	5	5	NUM
admet-169	69	35	%	%	NOUN
admet-169	69	36	co2	co2	NOUN
admet-169	69	37	and	and	CCONJ
admet-169	69	38	100	100	NUM
admet-169	69	39	%	%	NOUN
admet-169	69	40	humidity	humidity	NOUN
admet-169	69	41	.	.	PUNCT
admet-169	70	1	confluent	confluent	ADJ
admet-169	70	2	cells	cell	NOUN
admet-169	70	3	were	be	AUX
admet-169	70	4	detached	detach	VERB
admet-169	70	5	using	use	VERB
admet-169	70	6	trypsin	trypsin	NOUN
admet-169	70	7	edta	edta	NOUN
admet-169	70	8	and	and	CCONJ
admet-169	70	9	past	past	ADP
admet-169	70	10	twice	twice	ADJ
admet-169	70	11	weekly	weekly	ADJ
admet-169	70	12	.	.	PUNCT
admet-169	71	1	cells	cell	NOUN
admet-169	71	2	were	be	AUX
admet-169	71	3	seeded	seed	VERB
admet-169	71	4	at	at	ADP
admet-169	71	5	a	a	DET
admet-169	71	6	density	density	NOUN
admet-169	71	7	6.6	6.6	NUM
admet-169	71	8	x	x	SYM
admet-169	71	9	105	105	NUM
admet-169	71	10	cells/	cells/	NUM
admet-169	71	11	cm2	cm2	NOUN
admet-169	71	12	on	on	ADP
admet-169	71	13	a	a	DET
admet-169	71	14	biocoat	biocoat	ADJ
admet-169	71	15	24	24	NUM
admet-169	71	16	well	well	NOUN
admet-169	71	17	transwell	transwell	NOUN
admet-169	71	18	plate	plate	NOUN
admet-169	71	19	(	(	PUNCT
admet-169	71	20	1	1	NUM
admet-169	71	21	µm	µm	ADP
admet-169	71	22	pore	pore	ADJ
admet-169	71	23	size	size	NOUN
admet-169	71	24	,	,	PUNCT
admet-169	71	25	0.31	0.31	NUM
admet-169	71	26	cm2	cm2	PROPN
admet-169	71	27	surface	surface	NOUN
admet-169	71	28	area	area	NOUN
admet-169	71	29	)	)	PUNCT
admet-169	71	30	pre	pre	VERB
admet-169	71	31	-	-	VERB
admet-169	71	32	wetted	wet	VERB
admet-169	71	33	with	with	ADP
admet-169	71	34	50	50	NUM
admet-169	71	35	µl	µl	NOUN
admet-169	71	36	of	of	ADP
admet-169	71	37	growth	growth	NOUN
admet-169	71	38	medium	medium	NOUN
admet-169	71	39	for	for	ADP
admet-169	71	40	5	5	NUM
admet-169	71	41	–	–	SYM
admet-169	71	42	10	10	NUM
admet-169	71	43	minutes	minute	NOUN
admet-169	71	44	prior	prior	ADV
admet-169	71	45	to	to	ADP
admet-169	71	46	seeding	seed	VERB
admet-169	71	47	.	.	PUNCT
admet-169	72	1	plates	plate	NOUN
admet-169	72	2	were	be	AUX
admet-169	72	3	incubated	incubate	VERB
admet-169	72	4	for	for	ADP
admet-169	72	5	20	20	NUM
admet-169	72	6	–	–	SYM
admet-169	72	7	24	24	NUM
admet-169	72	8	hours	hour	NOUN
admet-169	72	9	with	with	ADP
admet-169	72	10	growth	growth	NOUN
admet-169	72	11	medium	medium	NOUN
admet-169	72	12	and	and	CCONJ
admet-169	72	13	then	then	ADV
admet-169	72	14	for	for	ADP
admet-169	72	15	44	44	NUM
admet-169	72	16	–	–	SYM
admet-169	72	17	48	48	NUM
admet-169	72	18	hours	hour	NOUN
admet-169	72	19	with	with	ADP
admet-169	72	20	differentiation	differentiation	NOUN
admet-169	72	21	medium	medium	NOUN
admet-169	72	22	at	at	ADP
admet-169	72	23	standard	standard	ADJ
admet-169	72	24	conditions	condition	NOUN
admet-169	72	25	.	.	PUNCT
admet-169	73	1	both	both	DET
admet-169	73	2	media	medium	NOUN
admet-169	73	3	were	be	AUX
admet-169	73	4	enriched	enrich	VERB
admet-169	73	5	with	with	ADP
admet-169	73	6	the	the	DET
admet-169	73	7	supplemental	supplemental	ADJ
admet-169	73	8	medium	medium	NOUN
admet-169	73	9	(	(	PUNCT
admet-169	73	10	1:1000	1:1000	NUM
admet-169	73	11	)	)	PUNCT
admet-169	73	12	and	and	CCONJ
admet-169	73	13	with	with	ADP
admet-169	73	14	1	1	NUM
admet-169	73	15	%	%	NOUN
admet-169	73	16	penicillin/	penicillin/	NUM
admet-169	73	17	streptomycin	streptomycin	PROPN
admet-169	73	18	while	while	SCONJ
admet-169	73	19	maintaining	maintain	VERB
admet-169	73	20	conditions	condition	NOUN
admet-169	73	21	for	for	ADP
admet-169	73	22	growth	growth	NOUN
admet-169	73	23	and	and	CCONJ
admet-169	73	24	differentiation	differentiation	NOUN
admet-169	73	25	as	as	SCONJ
admet-169	73	26	specified	specify	VERB
admet-169	73	27	by	by	ADP
admet-169	73	28	the	the	DET
admet-169	73	29	supplier	supplier	NOUN
admet-169	73	30	’s	’s	PART
admet-169	73	31	protocol	protocol	NOUN
admet-169	73	32	.	.	PUNCT
admet-169	74	1	in	in	ADP
admet-169	74	2	addition	addition	NOUN
admet-169	74	3	,	,	PUNCT
admet-169	74	4	the	the	DET
admet-169	74	5	plate	plate	NOUN
admet-169	74	6	was	be	AUX
admet-169	74	7	covered	cover	VERB
admet-169	74	8	with	with	ADP
admet-169	74	9	breathe	breathe	ADJ
admet-169	74	10	-	-	PUNCT
admet-169	74	11	easier	easy	ADJ
admet-169	74	12	cell	cell	NOUN
admet-169	74	13	culture	culture	NOUN
admet-169	74	14	foil	foil	NOUN
admet-169	74	15	during	during	ADP
admet-169	74	16	incubation	incubation	NOUN
admet-169	74	17	period	period	NOUN
admet-169	74	18	to	to	PART
admet-169	74	19	maintain	maintain	VERB
admet-169	74	20	identical	identical	ADJ
admet-169	74	21	environmental	environmental	ADJ
admet-169	74	22	conditions	condition	NOUN
admet-169	74	23	for	for	ADP
admet-169	74	24	each	each	DET
admet-169	74	25	well	well	NOUN
admet-169	74	26	.	.	PUNCT
admet-169	75	1	monolayer	monolayer	NOUN
admet-169	75	2	integrity	integrity	NOUN
admet-169	75	3	–	–	PUNCT
admet-169	75	4	transepithelial	transepithelial	ADJ
admet-169	75	5	electrical	electrical	ADJ
admet-169	75	6	resistance	resistance	NOUN
admet-169	75	7	(	(	PUNCT
admet-169	75	8	teer	teer	PROPN
admet-169	75	9	)	)	PUNCT
admet-169	75	10	the	the	DET
admet-169	75	11	development	development	NOUN
admet-169	75	12	of	of	ADP
admet-169	75	13	a	a	DET
admet-169	75	14	good	good	ADJ
admet-169	75	15	integrity	integrity	NOUN
admet-169	75	16	monolayer	monolayer	NOUN
admet-169	75	17	on	on	ADP
admet-169	75	18	semi	semi	ADJ
admet-169	75	19	-	-	ADJ
admet-169	75	20	permeable	permeable	ADJ
admet-169	75	21	filters	filter	NOUN
admet-169	75	22	in	in	ADP
admet-169	75	23	the	the	DET
admet-169	75	24	transwell	transwell	NOUN
admet-169	75	25	system	system	NOUN
admet-169	75	26	is	be	AUX
admet-169	75	27	the	the	DET
admet-169	75	28	initial	initial	ADJ
admet-169	75	29	crucial	crucial	ADJ
admet-169	75	30	step	step	NOUN
admet-169	75	31	prior	prior	ADV
admet-169	75	32	to	to	ADP
admet-169	75	33	any	any	DET
admet-169	75	34	drug	drug	NOUN
admet-169	75	35	uptake	uptake	NOUN
admet-169	75	36	and/or	and/or	CCONJ
admet-169	75	37	transport	transport	NOUN
admet-169	75	38	investigation	investigation	NOUN
admet-169	75	39	.	.	PUNCT
admet-169	76	1	transepithelial	transepithelial	ADJ
admet-169	76	2	electrical	electrical	ADJ
admet-169	76	3	resistance	resistance	NOUN
admet-169	76	4	(	(	PUNCT
admet-169	76	5	teer	teer	NOUN
admet-169	76	6	)	)	PUNCT
admet-169	76	7	measures	measure	VERB
admet-169	76	8	the	the	DET
admet-169	76	9	ion	ion	NOUN
admet-169	76	10	permeability	permeability	NOUN
admet-169	76	11	through	through	ADP
admet-169	76	12	the	the	DET
admet-169	76	13	paracellular	paracellular	ADJ
admet-169	76	14	pathways	pathway	NOUN
admet-169	76	15	and	and	CCONJ
admet-169	76	16	is	be	AUX
admet-169	76	17	used	use	VERB
admet-169	76	18	to	to	PART
admet-169	76	19	determine	determine	VERB
admet-169	76	20	the	the	DET
admet-169	76	21	“	"	PUNCT
admet-169	76	22	intactness	intactness	NOUN
admet-169	76	23	”	"	PUNCT
admet-169	76	24	of	of	ADP
admet-169	76	25	each	each	DET
admet-169	76	26	grown	grow	VERB
admet-169	76	27	monolayer	monolayer	NOUN
admet-169	76	28	.	.	PUNCT
admet-169	77	1	the	the	DET
admet-169	77	2	benefit	benefit	NOUN
admet-169	77	3	of	of	ADP
admet-169	77	4	teer	teer	NOUN
admet-169	77	5	is	be	AUX
admet-169	77	6	the	the	DET
admet-169	77	7	speed	speed	NOUN
admet-169	77	8	of	of	ADP
admet-169	77	9	measurements	measurement	NOUN
admet-169	77	10	and	and	CCONJ
admet-169	77	11	the	the	DET
admet-169	77	12	accuracy	accuracy	NOUN
admet-169	77	13	with	with	ADP
admet-169	77	14	which	which	PRON
admet-169	77	15	the	the	DET
admet-169	77	16	integrity	integrity	NOUN
admet-169	77	17	can	can	AUX
admet-169	77	18	be	be	AUX
admet-169	77	19	measured	measure	VERB
admet-169	77	20	.	.	PUNCT
admet-169	78	1	to	to	ADP
admet-169	78	2	this	this	DET
admet-169	78	3	end	end	NOUN
admet-169	78	4	transport	transport	NOUN
admet-169	78	5	medium	medium	NOUN
admet-169	78	6	was	be	AUX
admet-169	78	7	prepared	prepare	VERB
admet-169	78	8	on	on	ADP
admet-169	78	9	the	the	DET
admet-169	78	10	day	day	NOUN
admet-169	78	11	of	of	ADP
admet-169	78	12	treatment	treatment	NOUN
admet-169	78	13	by	by	ADP
admet-169	78	14	buffering	buffer	VERB
admet-169	78	15	hbss	hbss	NOUN
admet-169	78	16	;	;	PUNCT
admet-169	78	17	ph	ph	NOUN
admet-169	78	18	7.4	7.4	NUM
admet-169	78	19	with	with	ADP
admet-169	78	20	25	25	NUM
admet-169	78	21	mm	mm	PROPN
admet-169	78	22	hepes	hepe	NOUN
admet-169	78	23	and	and	CCONJ
admet-169	78	24	0.35	0.35	NUM
admet-169	78	25	g/	g/	NOUN
admet-169	78	26	litre	litre	NOUN
admet-169	78	27	nahco3	nahco3	NOUN
admet-169	79	1	[	[	X
admet-169	79	2	23	23	NUM
admet-169	79	3	]	]	PUNCT
admet-169	79	4	then	then	ADV
admet-169	79	5	adjusted	adjust	VERB
admet-169	79	6	to	to	ADP
admet-169	79	7	ph	ph	PROPN
admet-169	79	8	7.4	7.4	NUM
admet-169	79	9	with	with	ADP
admet-169	79	10	naoh	naoh	NOUN
admet-169	79	11	.	.	PUNCT
admet-169	80	1	within	within	ADP
admet-169	80	2	the	the	DET
admet-169	80	3	transwell	transwell	NOUN
admet-169	80	4	plate	plate	NOUN
admet-169	80	5	the	the	DET
admet-169	80	6	differentiation	differentiation	NOUN
admet-169	80	7	medium	medium	NOUN
admet-169	80	8	was	be	AUX
admet-169	80	9	replaced	replace	VERB
admet-169	80	10	with	with	ADP
admet-169	80	11	prepared	prepared	ADJ
admet-169	80	12	transport	transport	NOUN
admet-169	80	13	medium	medium	ADJ
admet-169	80	14	(	(	PUNCT
admet-169	80	15	apical	apical	ADJ
admet-169	80	16	300	300	NUM
admet-169	80	17	µl	µl	ADP
admet-169	80	18	and	and	CCONJ
admet-169	80	19	basolateral	basolateral	ADJ
admet-169	80	20	1	1	NUM
admet-169	80	21	ml	ml	NOUN
admet-169	80	22	)	)	PUNCT
admet-169	80	23	and	and	CCONJ
admet-169	80	24	incubated	incubate	VERB
admet-169	80	25	for	for	ADP
admet-169	80	26	15	15	NUM
admet-169	80	27	minutes	minute	NOUN
admet-169	80	28	with	with	ADP
admet-169	80	29	gentle	gentle	ADJ
admet-169	80	30	agitation	agitation	NOUN
admet-169	80	31	(	(	PUNCT
admet-169	80	32	100	100	NUM
admet-169	80	33	rpm	rpm	NOUN
admet-169	80	34	)	)	PUNCT
admet-169	80	35	under	under	ADP
admet-169	80	36	admet	admet	PROPN
admet-169	80	37	&	&	CCONJ
admet-169	80	38	dmpk	dmpk	PROPN
admet-169	80	39	3(1	3(1	NUM
admet-169	80	40	)	)	PUNCT
admet-169	80	41	(	(	PUNCT
admet-169	80	42	2015	2015	NUM
admet-169	80	43	)	)	PUNCT
admet-169	80	44	51	51	NUM
admet-169	80	45	-	-	SYM
admet-169	80	46	67	67	NUM
admet-169	80	47	adaptation	adaptation	NOUN
admet-169	80	48	of	of	ADP
admet-169	80	49	human	human	ADJ
admet-169	80	50	gut	gut	NOUN
admet-169	80	51	epithelial	epithelial	ADJ
admet-169	80	52	model	model	NOUN
admet-169	80	53	doi	doi	NOUN
admet-169	80	54	:	:	PUNCT
admet-169	80	55	10.5599	10.5599	NUM
admet-169	80	56	/	/	SYM
admet-169	80	57	admet.3.1.169	admet.3.1.169	PROPN
admet-169	80	58	55	55	NUM
admet-169	80	59	standard	standard	ADJ
admet-169	80	60	conditions	condition	NOUN
admet-169	80	61	.	.	PUNCT
admet-169	81	1	teer	teer	PROPN
admet-169	81	2	was	be	AUX
admet-169	81	3	determined	determine	VERB
admet-169	81	4	using	use	VERB
admet-169	81	5	the	the	DET
admet-169	81	6	potential	potential	ADJ
admet-169	81	7	difference	difference	NOUN
admet-169	81	8	between	between	ADP
admet-169	81	9	two	two	NUM
admet-169	81	10	electrodes	electrode	NOUN
admet-169	81	11	suspended	suspend	VERB
admet-169	81	12	across	across	ADP
admet-169	81	13	the	the	DET
admet-169	81	14	monolayer	monolayer	NOUN
admet-169	81	15	.	.	PUNCT
admet-169	82	1	measurement	measurement	NOUN
admet-169	82	2	between	between	ADP
admet-169	82	3	each	each	PRON
admet-169	82	4	well	well	ADV
admet-169	82	5	was	be	AUX
admet-169	82	6	performed	perform	VERB
admet-169	82	7	after	after	ADP
admet-169	82	8	a	a	DET
admet-169	82	9	short	short	ADJ
admet-169	82	10	washing	washing	NOUN
admet-169	82	11	period	period	NOUN
admet-169	82	12	of	of	ADP
admet-169	82	13	the	the	DET
admet-169	82	14	electrodes	electrode	NOUN
admet-169	82	15	in	in	ADP
admet-169	82	16	ethanol	ethanol	NOUN
admet-169	82	17	then	then	ADV
admet-169	82	18	transport	transport	VERB
admet-169	82	19	medium	medium	NOUN
admet-169	82	20	.	.	PUNCT
admet-169	83	1	the	the	DET
admet-169	83	2	resistance	resistance	NOUN
admet-169	83	3	measured	measure	VERB
admet-169	83	4	for	for	ADP
admet-169	83	5	each	each	DET
admet-169	83	6	monolayer	monolayer	NOUN
admet-169	83	7	before	before	ADV
admet-169	83	8	and	and	CCONJ
admet-169	83	9	after	after	SCONJ
admet-169	83	10	the	the	DET
admet-169	83	11	experiment	experiment	NOUN
admet-169	83	12	was	be	AUX
admet-169	83	13	adjusted	adjust	VERB
admet-169	83	14	by	by	ADP
admet-169	83	15	a	a	DET
admet-169	83	16	blank	blank	ADJ
admet-169	83	17	resistance	resistance	NOUN
admet-169	83	18	determined	determine	VERB
admet-169	83	19	from	from	ADP
admet-169	83	20	the	the	DET
admet-169	83	21	wells	well	NOUN
admet-169	83	22	without	without	ADP
admet-169	83	23	a	a	DET
admet-169	83	24	monolayer	monolayer	NOUN
admet-169	83	25	and	and	CCONJ
admet-169	83	26	multiplied	multiply	VERB
admet-169	83	27	by	by	ADP
admet-169	83	28	0.31	0.31	NUM
admet-169	83	29	cm	cm	NOUN
admet-169	83	30	2	2	NUM
admet-169	83	31	(	(	PUNCT
admet-169	83	32	the	the	DET
admet-169	83	33	area	area	NOUN
admet-169	83	34	of	of	ADP
admet-169	83	35	effective	effective	ADJ
admet-169	83	36	membrane	membrane	NOUN
admet-169	83	37	diameter	diameter	NOUN
admet-169	83	38	)	)	PUNCT
admet-169	83	39	.	.	PUNCT
admet-169	84	1	a	a	DET
admet-169	84	2	cut	cut	VERB
admet-169	84	3	off	off	ADP
admet-169	84	4	value	value	NOUN
admet-169	84	5	of	of	ADP
admet-169	84	6	600	600	NUM
admet-169	84	7	–	–	SYM
admet-169	84	8	1600	1600	NUM
admet-169	84	9	ω	ω	NUM
admet-169	84	10	cm	cm	NOUN
admet-169	84	11	2	2	NUM
admet-169	84	12	was	be	AUX
admet-169	84	13	used	use	VERB
admet-169	84	14	for	for	ADP
admet-169	84	15	determining	determine	VERB
admet-169	84	16	monolayer	monolayer	NOUN
admet-169	84	17	integrity	integrity	NOUN
admet-169	84	18	according	accord	VERB
admet-169	84	19	to	to	ADP
admet-169	84	20	specifications	specification	NOUN
admet-169	84	21	obtained	obtain	VERB
admet-169	84	22	from	from	ADP
admet-169	84	23	bd	bd	PROPN
admet-169	84	24	biocoat	biocoat	PROPN
admet-169	84	25	™	™	PROPN
admet-169	84	26	.	.	PUNCT
admet-169	85	1	transport	transport	NOUN
admet-169	85	2	studies	study	NOUN
admet-169	85	3	transport	transport	VERB
admet-169	85	4	studies	study	NOUN
admet-169	85	5	of	of	ADP
admet-169	85	6	20	20	NUM
admet-169	85	7	µm	µm	NOUN
admet-169	85	8	erlotinib	erlotinib	NOUN
admet-169	85	9	and	and	CCONJ
admet-169	85	10	gefitinib	gefitinib	NOUN
admet-169	85	11	were	be	AUX
admet-169	85	12	performed	perform	VERB
admet-169	85	13	in	in	ADP
admet-169	85	14	the	the	DET
admet-169	85	15	direction	direction	NOUN
admet-169	85	16	apical	apical	ADJ
admet-169	85	17	to	to	ADP
admet-169	85	18	basolateral	basolateral	NOUN
admet-169	85	19	(	(	PUNCT
admet-169	85	20	a	a	DET
admet-169	85	21	b	b	NOUN
admet-169	85	22	)	)	PUNCT
admet-169	85	23	and	and	CCONJ
admet-169	85	24	in	in	ADP
admet-169	85	25	the	the	DET
admet-169	85	26	direction	direction	NOUN
admet-169	85	27	basolateral	basolateral	NOUN
admet-169	85	28	to	to	ADP
admet-169	85	29	apical	apical	ADJ
admet-169	85	30	(	(	PUNCT
admet-169	85	31	b	b	NOUN
admet-169	85	32	a	a	NOUN
admet-169	85	33	)	)	PUNCT
admet-169	85	34	.	.	PUNCT
admet-169	86	1	inhibition	inhibition	NOUN
admet-169	86	2	of	of	ADP
admet-169	86	3	cellular	cellular	ADJ
admet-169	86	4	pump	pump	NOUN
admet-169	86	5	function	function	NOUN
admet-169	86	6	was	be	AUX
admet-169	86	7	investigated	investigate	VERB
admet-169	86	8	with	with	ADP
admet-169	86	9	either	either	CCONJ
admet-169	86	10	200	200	NUM
admet-169	86	11	nm	nm	ADJ
admet-169	86	12	ko143	ko143	NOUN
admet-169	86	13	or	or	CCONJ
admet-169	86	14	1	1	NUM
admet-169	86	15	mm	mm	PROPN
admet-169	86	16	nan3	nan3	PROPN
admet-169	86	17	.	.	PUNCT
admet-169	87	1	wells	well	NOUN
admet-169	87	2	were	be	AUX
admet-169	87	3	pre	pre	VERB
admet-169	87	4	-	-	VERB
admet-169	87	5	incubated	incubate	VERB
admet-169	87	6	under	under	ADP
admet-169	87	7	standard	standard	ADJ
admet-169	87	8	conditions	condition	NOUN
admet-169	87	9	for	for	ADP
admet-169	87	10	20	20	NUM
admet-169	87	11	minutes	minute	NOUN
admet-169	87	12	with	with	ADP
admet-169	87	13	400	400	NUM
admet-169	87	14	nm	nm	NOUN
admet-169	87	15	ko143	ko143	NOUN
admet-169	87	16	or	or	CCONJ
admet-169	87	17	1	1	NUM
admet-169	87	18	hour	hour	NOUN
admet-169	87	19	with	with	ADP
admet-169	87	20	3	3	NUM
admet-169	87	21	mm	mm	PROPN
admet-169	87	22	nan3	nan3	PROPN
admet-169	87	23	;	;	PUNCT
admet-169	87	24	gentle	gentle	ADJ
admet-169	87	25	agitation	agitation	NOUN
admet-169	87	26	(	(	PUNCT
admet-169	87	27	100	100	NUM
admet-169	87	28	rpm	rpm	NOUN
admet-169	87	29	)	)	PUNCT
admet-169	87	30	was	be	AUX
admet-169	87	31	applied	apply	VERB
admet-169	87	32	during	during	ADP
admet-169	87	33	the	the	DET
admet-169	87	34	incubation	incubation	NOUN
admet-169	87	35	.	.	PUNCT
admet-169	88	1	all	all	DET
admet-169	88	2	drugs	drug	NOUN
admet-169	88	3	were	be	AUX
admet-169	88	4	dissolved	dissolve	VERB
admet-169	88	5	in	in	ADP
admet-169	88	6	transport	transport	NOUN
admet-169	88	7	medium	medium	NOUN
admet-169	88	8	either	either	CCONJ
admet-169	88	9	containing	contain	VERB
admet-169	88	10	5	5	NUM
admet-169	88	11	%	%	NOUN
admet-169	88	12	bsa	bsa	NOUN
admet-169	88	13	or	or	CCONJ
admet-169	88	14	containing	contain	VERB
admet-169	88	15	5	5	NUM
admet-169	88	16	%	%	NOUN
admet-169	88	17	bsa	bsa	NOUN
admet-169	88	18	+	+	CCONJ
admet-169	88	19	1	1	NUM
admet-169	88	20	mm	mm	PROPN
admet-169	88	21	nan3	nan3	PROPN
admet-169	88	22	and	and	CCONJ
admet-169	88	23	added	add	VERB
admet-169	88	24	to	to	ADP
admet-169	88	25	the	the	DET
admet-169	88	26	donor	donor	NOUN
admet-169	88	27	compartment	compartment	VERB
admet-169	88	28	either	either	CCONJ
admet-169	88	29	apical	apical	ADJ
admet-169	88	30	(	(	PUNCT
admet-169	88	31	300	300	NUM
admet-169	88	32	µl	µl	NOUN
admet-169	88	33	)	)	PUNCT
admet-169	88	34	or	or	CCONJ
admet-169	88	35	basolateral	basolateral	ADJ
admet-169	88	36	(	(	PUNCT
admet-169	88	37	1	1	NUM
admet-169	88	38	ml	ml	NOUN
admet-169	88	39	)	)	PUNCT
admet-169	88	40	.	.	PUNCT
admet-169	89	1	the	the	DET
admet-169	89	2	initial	initial	ADJ
admet-169	89	3	concentration	concentration	NOUN
admet-169	89	4	of	of	ADP
admet-169	89	5	the	the	DET
admet-169	89	6	drug	drug	NOUN
admet-169	89	7	was	be	AUX
admet-169	89	8	verified	verify	VERB
admet-169	89	9	from	from	ADP
admet-169	89	10	a	a	DET
admet-169	89	11	20	20	NUM
admet-169	89	12	µl	µl	ADP
admet-169	89	13	sample	sample	NOUN
admet-169	89	14	taken	take	VERB
admet-169	89	15	immediately	immediately	ADV
admet-169	89	16	from	from	ADP
admet-169	89	17	the	the	DET
admet-169	89	18	donor	donor	NOUN
admet-169	89	19	compartment	compartment	NOUN
admet-169	89	20	after	after	ADP
admet-169	89	21	drug	drug	NOUN
admet-169	89	22	administration	administration	NOUN
admet-169	89	23	(	(	PUNCT
admet-169	89	24	t	t	NOUN
admet-169	89	25	=	=	SYM
admet-169	89	26	0	0	NUM
admet-169	89	27	)	)	PUNCT
admet-169	89	28	.	.	PUNCT
admet-169	90	1	subsequently	subsequently	ADV
admet-169	90	2	,	,	PUNCT
admet-169	90	3	samples	sample	NOUN
admet-169	90	4	(	(	PUNCT
admet-169	90	5	50	50	NUM
admet-169	90	6	µl	µl	NOUN
admet-169	90	7	)	)	PUNCT
admet-169	90	8	were	be	AUX
admet-169	90	9	taken	take	VERB
admet-169	90	10	from	from	ADP
admet-169	90	11	each	each	DET
admet-169	90	12	receiver	receiver	ADJ
admet-169	90	13	compartment	compartment	NOUN
admet-169	90	14	at	at	ADP
admet-169	90	15	the	the	DET
admet-169	90	16	time	time	NOUN
admet-169	90	17	points	point	NOUN
admet-169	90	18	15	15	NUM
admet-169	90	19	,	,	PUNCT
admet-169	90	20	30	30	NUM
admet-169	90	21	,	,	PUNCT
admet-169	90	22	60	60	NUM
admet-169	90	23	,	,	PUNCT
admet-169	90	24	90	90	NUM
admet-169	90	25	,	,	PUNCT
admet-169	90	26	120	120	NUM
admet-169	90	27	and	and	CCONJ
admet-169	90	28	180	180	NUM
admet-169	90	29	minutes	minute	NOUN
admet-169	90	30	after	after	ADP
admet-169	90	31	drug	drug	NOUN
admet-169	90	32	administration	administration	NOUN
admet-169	90	33	.	.	PUNCT
admet-169	91	1	following	follow	VERB
admet-169	91	2	each	each	DET
admet-169	91	3	sampling	sampling	NOUN
admet-169	91	4	,	,	PUNCT
admet-169	91	5	the	the	DET
admet-169	91	6	volume	volume	NOUN
admet-169	91	7	of	of	ADP
admet-169	91	8	sample	sample	NOUN
admet-169	91	9	taken	take	VERB
admet-169	91	10	was	be	AUX
admet-169	91	11	replaced	replace	VERB
admet-169	91	12	by	by	ADP
admet-169	91	13	the	the	DET
admet-169	91	14	same	same	ADJ
admet-169	91	15	amount	amount	NOUN
admet-169	91	16	of	of	ADP
admet-169	91	17	pre	pre	ADJ
admet-169	91	18	-	-	ADJ
admet-169	91	19	warmed	warm	VERB
admet-169	91	20	transport	transport	NOUN
admet-169	91	21	medium	medium	NOUN
admet-169	91	22	.	.	PUNCT
admet-169	92	1	the	the	DET
admet-169	92	2	plate	plate	NOUN
admet-169	92	3	was	be	AUX
admet-169	92	4	incubated	incubate	VERB
admet-169	92	5	with	with	ADP
admet-169	92	6	gentle	gentle	ADJ
admet-169	92	7	agitation	agitation	NOUN
admet-169	92	8	(	(	PUNCT
admet-169	92	9	100	100	NUM
admet-169	92	10	rpm	rpm	NOUN
admet-169	92	11	)	)	PUNCT
admet-169	92	12	at	at	ADP
admet-169	92	13	standard	standard	ADJ
admet-169	92	14	conditions	condition	NOUN
admet-169	92	15	between	between	ADP
admet-169	92	16	each	each	DET
admet-169	92	17	time	time	NOUN
admet-169	92	18	point	point	NOUN
admet-169	92	19	.	.	PUNCT
admet-169	93	1	a	a	DET
admet-169	93	2	final	final	ADJ
admet-169	93	3	sample	sample	NOUN
admet-169	93	4	of	of	ADP
admet-169	93	5	20	20	NUM
admet-169	93	6	µl	µl	NOUN
admet-169	93	7	was	be	AUX
admet-169	93	8	taken	take	VERB
admet-169	93	9	from	from	ADP
admet-169	93	10	the	the	DET
admet-169	93	11	donor	donor	NOUN
admet-169	93	12	compartment	compartment	NOUN
admet-169	93	13	after	after	ADP
admet-169	93	14	180	180	NUM
admet-169	93	15	minutes	minute	NOUN
admet-169	93	16	.	.	PUNCT
admet-169	94	1	all	all	DET
admet-169	94	2	samples	sample	NOUN
admet-169	94	3	were	be	AUX
admet-169	94	4	placed	place	VERB
admet-169	94	5	in	in	ADP
admet-169	94	6	pre	pre	ADJ
admet-169	94	7	-	-	ADJ
admet-169	94	8	labelled	labelled	ADJ
admet-169	94	9	tubes	tube	NOUN
admet-169	94	10	,	,	PUNCT
admet-169	94	11	stored	store	VERB
admet-169	94	12	on	on	ADP
admet-169	94	13	ice	ice	NOUN
admet-169	94	14	temporarily	temporarily	ADV
admet-169	94	15	during	during	ADP
admet-169	94	16	the	the	DET
admet-169	94	17	experiment	experiment	NOUN
admet-169	94	18	,	,	PUNCT
admet-169	94	19	snap	snap	VERB
admet-169	94	20	frozen	freeze	VERB
admet-169	94	21	in	in	ADP
admet-169	94	22	liquid	liquid	ADJ
admet-169	94	23	nitrogen	nitrogen	NOUN
admet-169	94	24	and	and	CCONJ
admet-169	94	25	stored	store	VERB
admet-169	94	26	at	at	ADP
admet-169	94	27	-80	-80	NOUN
admet-169	94	28	°	°	NOUN
admet-169	94	29	c	c	NOUN
admet-169	94	30	until	until	SCONJ
admet-169	94	31	required	require	VERB
admet-169	94	32	for	for	ADP
admet-169	94	33	analysis	analysis	NOUN
admet-169	94	34	.	.	PUNCT
admet-169	95	1	after	after	ADP
admet-169	95	2	the	the	DET
admet-169	95	3	final	final	ADJ
admet-169	95	4	sample	sample	NOUN
admet-169	95	5	time	time	NOUN
admet-169	95	6	point	point	NOUN
admet-169	95	7	,	,	PUNCT
admet-169	95	8	cells	cell	NOUN
admet-169	95	9	were	be	AUX
admet-169	95	10	washed	wash	VERB
admet-169	95	11	,	,	PUNCT
admet-169	95	12	trypsinized	trypsinize	VERB
admet-169	95	13	and	and	CCONJ
admet-169	95	14	harvested	harvest	VERB
admet-169	95	15	;	;	PUNCT
admet-169	95	16	the	the	DET
admet-169	95	17	pellets	pellet	NOUN
admet-169	95	18	were	be	AUX
admet-169	95	19	stored	store	VERB
admet-169	95	20	at	at	ADP
admet-169	95	21	-80	-80	NOUN
admet-169	95	22	°	°	ADP
admet-169	95	23	c	c	NOUN
admet-169	95	24	until	until	ADP
admet-169	95	25	analysis	analysis	NOUN
admet-169	95	26	.	.	PUNCT
admet-169	96	1	liquid	liquid	ADJ
admet-169	96	2	chromatography	chromatography	NOUN
admet-169	96	3	analysis	analysis	NOUN
admet-169	96	4	extractions	extraction	NOUN
admet-169	96	5	for	for	ADP
admet-169	96	6	chromatographic	chromatographic	ADJ
admet-169	96	7	analysis	analysis	NOUN
admet-169	96	8	of	of	ADP
admet-169	96	9	standard	standard	NOUN
admet-169	96	10	and	and	CCONJ
admet-169	96	11	samples	sample	NOUN
admet-169	96	12	were	be	AUX
admet-169	96	13	all	all	PRON
admet-169	96	14	performed	perform	VERB
admet-169	96	15	on	on	ADP
admet-169	96	16	ice	ice	NOUN
admet-169	96	17	as	as	ADP
admet-169	96	18	detailed	detailed	ADJ
admet-169	96	19	.	.	PUNCT
admet-169	97	1	analysis	analysis	NOUN
admet-169	97	2	of	of	ADP
admet-169	97	3	samples	sample	NOUN
admet-169	97	4	taken	take	VERB
admet-169	97	5	from	from	ADP
admet-169	97	6	the	the	DET
admet-169	97	7	donor	donor	NOUN
admet-169	97	8	and	and	CCONJ
admet-169	97	9	receiver	receiver	ADJ
admet-169	97	10	compartments	compartment	NOUN
admet-169	97	11	as	as	ADV
admet-169	97	12	well	well	ADV
admet-169	97	13	as	as	ADP
admet-169	97	14	the	the	DET
admet-169	97	15	prepared	prepare	VERB
admet-169	97	16	cell	cell	NOUN
admet-169	97	17	pellet	pellet	NOUN
admet-169	97	18	was	be	AUX
admet-169	97	19	performed	perform	VERB
admet-169	97	20	by	by	ADP
admet-169	97	21	lc	lc	NOUN
admet-169	97	22	-	-	PUNCT
admet-169	97	23	ms/	ms/	NOUN
admet-169	97	24	ms	ms	PROPN
admet-169	97	25	techniques	technique	NOUN
admet-169	97	26	.	.	PUNCT
admet-169	98	1	a	a	DET
admet-169	98	2	simple	simple	ADJ
admet-169	98	3	extraction	extraction	NOUN
admet-169	98	4	procedure	procedure	NOUN
admet-169	98	5	of	of	ADP
admet-169	98	6	protein	protein	NOUN
admet-169	98	7	precipitation	precipitation	NOUN
admet-169	98	8	with	with	ADP
admet-169	98	9	acetonitrile	acetonitrile	NOUN
admet-169	98	10	was	be	AUX
admet-169	98	11	performed	perform	VERB
admet-169	98	12	for	for	ADP
admet-169	98	13	each	each	DET
admet-169	98	14	sample	sample	NOUN
admet-169	98	15	and	and	CCONJ
admet-169	98	16	standard	standard	ADJ
admet-169	98	17	preparation	preparation	NOUN
admet-169	98	18	as	as	SCONJ
admet-169	98	19	reported	report	VERB
admet-169	98	20	previously	previously	ADV
admet-169	98	21	[	[	X
admet-169	98	22	25	25	NUM
admet-169	98	23	]	]	PUNCT
admet-169	98	24	.	.	PUNCT
admet-169	99	1	lc	lc	NOUN
admet-169	99	2	-	-	PUNCT
admet-169	99	3	ms/	ms/	NOUN
admet-169	99	4	ms	ms	NOUN
admet-169	99	5	analysis	analysis	NOUN
admet-169	99	6	was	be	AUX
admet-169	99	7	performed	perform	VERB
admet-169	99	8	with	with	ADP
admet-169	99	9	a	a	DET
admet-169	99	10	mobile	mobile	ADJ
admet-169	99	11	phase	phase	NOUN
admet-169	99	12	consisting	consist	VERB
admet-169	99	13	of	of	ADP
admet-169	99	14	acetonitrile	acetonitrile	NOUN
admet-169	99	15	,	,	PUNCT
admet-169	99	16	ammonium	ammonium	NOUN
admet-169	99	17	acetate	acetate	NOUN
admet-169	99	18	(	(	PUNCT
admet-169	99	19	20	20	NUM
admet-169	99	20	mm	mm	NOUN
admet-169	99	21	,	,	PUNCT
admet-169	99	22	ph	ph	NOUN
admet-169	99	23	7.8	7.8	NUM
admet-169	99	24	)	)	PUNCT
admet-169	99	25	and	and	CCONJ
admet-169	99	26	methanol	methanol	NOUN
admet-169	99	27	in	in	ADP
admet-169	99	28	the	the	DET
admet-169	99	29	ratio	ratio	NOUN
admet-169	99	30	of	of	ADP
admet-169	99	31	66.1:24.5:8.3	66.1:24.5:8.3	NUM
admet-169	99	32	%	%	NOUN
admet-169	99	33	(	(	PUNCT
admet-169	99	34	v	v	NOUN
admet-169	99	35	/	/	SYM
admet-169	99	36	v	v	NOUN
admet-169	99	37	)	)	PUNCT
admet-169	99	38	with	with	SCONJ
admet-169	99	39	1	1	NUM
admet-169	99	40	%	%	NOUN
admet-169	99	41	isopropyl	isopropyl	NOUN
admet-169	99	42	alcohol	alcohol	NOUN
admet-169	99	43	added	add	VERB
admet-169	99	44	as	as	ADP
admet-169	99	45	a	a	DET
admet-169	99	46	chromatographic	chromatographic	ADJ
admet-169	99	47	modifier	modifier	NOUN
admet-169	99	48	.	.	PUNCT
admet-169	100	1	chromatographic	chromatographic	ADJ
admet-169	100	2	separation	separation	NOUN
admet-169	100	3	was	be	AUX
admet-169	100	4	obtained	obtain	VERB
admet-169	100	5	with	with	ADP
admet-169	100	6	a	a	DET
admet-169	100	7	phenomenex	phenomenex	ADV
admet-169	100	8	prodigy	prodigy	NOUN
admet-169	100	9	ods3	ods3	PROPN
admet-169	100	10	column	column	PROPN
admet-169	100	11	,	,	PUNCT
admet-169	100	12	3	3	NUM
admet-169	100	13	µm	µm	ADP
admet-169	100	14	particle	particle	NOUN
admet-169	100	15	sizes	size	NOUN
admet-169	100	16	,	,	PUNCT
admet-169	100	17	100	100	NUM
admet-169	100	18	x	x	SYM
admet-169	100	19	2.00	2.00	NUM
admet-169	100	20	mm	mm	NOUN
admet-169	100	21	(	(	PUNCT
admet-169	100	22	phenomenex	phenomenex	ADV
admet-169	100	23	,	,	PUNCT
admet-169	100	24	the	the	DET
admet-169	100	25	netherlands	netherlands	PROPN
admet-169	100	26	)	)	PUNCT
admet-169	100	27	at	at	ADP
admet-169	100	28	a	a	DET
admet-169	100	29	flow	flow	NOUN
admet-169	100	30	rate	rate	NOUN
admet-169	100	31	of	of	ADP
admet-169	100	32	0.2	0.2	NUM
admet-169	100	33	ml/	ml/	NOUN
admet-169	100	34	minute	minute	NOUN
admet-169	100	35	.	.	PUNCT
admet-169	101	1	all	all	DET
admet-169	101	2	mobile	mobile	ADJ
admet-169	101	3	phases	phase	NOUN
admet-169	101	4	were	be	AUX
admet-169	101	5	filtered	filter	VERB
admet-169	101	6	through	through	ADP
admet-169	101	7	a	a	DET
admet-169	101	8	0.2	0.2	NUM
admet-169	101	9	µm	µm	ADP
admet-169	101	10	sartorius	sartorius	NOUN
admet-169	101	11	membrane	membrane	NOUN
admet-169	101	12	filter	filter	NOUN
admet-169	101	13	and	and	CCONJ
admet-169	101	14	degassed	degas	VERB
admet-169	101	15	for	for	ADP
admet-169	101	16	5	5	NUM
admet-169	101	17	minutes	minute	NOUN
admet-169	101	18	under	under	ADP
admet-169	101	19	vacuum	vacuum	NOUN
admet-169	101	20	with	with	ADP
admet-169	101	21	sonication	sonication	NOUN
admet-169	101	22	.	.	PUNCT
admet-169	102	1	calculation	calculation	NOUN
admet-169	102	2	and	and	CCONJ
admet-169	102	3	statistics	statistic	NOUN
admet-169	102	4	the	the	DET
admet-169	102	5	permeability	permeability	NOUN
admet-169	102	6	coefficient	coefficient	NOUN
admet-169	102	7	(	(	PUNCT
admet-169	102	8	papp	papp	NOUN
admet-169	102	9	)	)	PUNCT
admet-169	102	10	represents	represent	VERB
admet-169	102	11	a	a	DET
admet-169	102	12	measure	measure	NOUN
admet-169	102	13	for	for	ADP
admet-169	102	14	the	the	DET
admet-169	102	15	efficiency	efficiency	NOUN
admet-169	102	16	of	of	ADP
admet-169	102	17	transport	transport	NOUN
admet-169	102	18	and	and	CCONJ
admet-169	102	19	was	be	AUX
admet-169	102	20	calculated	calculate	VERB
admet-169	102	21	using	use	VERB
admet-169	102	22	the	the	DET
admet-169	102	23	total	total	ADJ
admet-169	102	24	drug	drug	NOUN
admet-169	102	25	concentration	concentration	NOUN
admet-169	102	26	per	per	ADP
admet-169	102	27	sample	sample	NOUN
admet-169	102	28	well	well	ADV
admet-169	102	29	with	with	ADP
admet-169	102	30	the	the	DET
admet-169	102	31	following	follow	VERB
admet-169	102	32	equation	equation	NOUN
admet-169	102	33	:	:	PUNCT
admet-169	102	34	ac	ac	PROPN
admet-169	102	35	v	v	INTJ
admet-169	102	36	x	x	SYM
admet-169	102	37	t	t	PROPN
admet-169	102	38	q	q	PROPN
admet-169	102	39	papp	papp	PROPN
admet-169	102	40	.0	.0	PUNCT
admet-169	103	1			X
admet-169	104	1			NUM
admet-169	104	2	peters	peters	PROPN
admet-169	104	3	et	et	PROPN
admet-169	104	4	al	al	PROPN
admet-169	104	5	.	.	PROPN
admet-169	104	6	admet	admet	PROPN
admet-169	104	7	&	&	CCONJ
admet-169	104	8	dmpk	dmpk	PROPN
admet-169	104	9	3(1	3(1	NUM
admet-169	104	10	)	)	PUNCT
admet-169	104	11	(	(	PUNCT
admet-169	104	12	2015	2015	NUM
admet-169	104	13	)	)	PUNCT
admet-169	104	14	51	51	NUM
admet-169	104	15	-	-	SYM
admet-169	104	16	67	67	NUM
admet-169	104	17	56	56	NUM
admet-169	104	18	where	where	SCONJ
admet-169	104	19	∆q/	∆q/	ADP
admet-169	104	20	∆t	∆t	PROPN
admet-169	104	21	=	=	PRON
admet-169	104	22	the	the	DET
admet-169	104	23	rate	rate	NOUN
admet-169	104	24	of	of	ADP
admet-169	104	25	increase	increase	NOUN
admet-169	104	26	in	in	ADP
admet-169	104	27	drug	drug	NOUN
admet-169	104	28	concentration	concentration	NOUN
admet-169	104	29	(	(	PUNCT
admet-169	104	30	accumulative	accumulative	ADJ
admet-169	104	31	mass	mass	NOUN
admet-169	104	32	transport	transport	NOUN
admet-169	104	33	)	)	PUNCT
admet-169	104	34	in	in	ADP
admet-169	104	35	the	the	DET
admet-169	104	36	receiver	receiver	NOUN
admet-169	104	37	compartment	compartment	NOUN
admet-169	104	38	over	over	ADP
admet-169	104	39	time	time	NOUN
admet-169	104	40	(	(	PUNCT
admet-169	104	41	µm/	µm/	PROPN
admet-169	104	42	second	second	ADJ
admet-169	104	43	)	)	PUNCT
admet-169	104	44	,	,	PUNCT
admet-169	104	45	v	v	X
admet-169	104	46	=	=	SYM
admet-169	104	47	volume	volume	NOUN
admet-169	104	48	in	in	ADP
admet-169	104	49	the	the	DET
admet-169	104	50	receiver	receiver	ADJ
admet-169	104	51	compartment	compartment	NOUN
admet-169	104	52	(	(	PUNCT
admet-169	104	53	ml	ml	NOUN
admet-169	104	54	)	)	PUNCT
admet-169	104	55	,	,	PUNCT
admet-169	104	56	c0	c0	NOUN
admet-169	104	57	=	=	PUNCT
admet-169	104	58	the	the	DET
admet-169	104	59	initial	initial	ADJ
admet-169	104	60	concentration	concentration	NOUN
admet-169	104	61	of	of	ADP
admet-169	104	62	drug	drug	NOUN
admet-169	104	63	in	in	ADP
admet-169	104	64	the	the	DET
admet-169	104	65	donor	donor	NOUN
admet-169	104	66	compartment	compartment	NOUN
admet-169	104	67	(	(	PUNCT
admet-169	104	68	µm	µm	NOUN
admet-169	104	69	)	)	PUNCT
admet-169	104	70	,	,	PUNCT
admet-169	104	71	and	and	CCONJ
admet-169	104	72	a	a	DET
admet-169	104	73	=	=	X
admet-169	104	74	the	the	DET
admet-169	104	75	membrane	membrane	NOUN
admet-169	104	76	surface	surface	NOUN
admet-169	104	77	area	area	NOUN
admet-169	104	78	(	(	PUNCT
admet-169	104	79	cm	cm	NOUN
admet-169	104	80	2	2	NUM
admet-169	104	81	)	)	PUNCT
admet-169	104	82	.	.	PUNCT
admet-169	105	1	the	the	DET
admet-169	105	2	efflux	efflux	NOUN
admet-169	105	3	ratio	ratio	NOUN
admet-169	105	4	was	be	AUX
admet-169	105	5	calculated	calculate	VERB
admet-169	105	6	according	accord	VERB
admet-169	105	7	to	to	ADP
admet-169	105	8	the	the	DET
admet-169	105	9	equation	equation	NOUN
admet-169	105	10	:	:	PUNCT
admet-169	105	11	efflux	efflux	VERB
admet-169	105	12	ratio	ratio	NOUN
admet-169	105	13	bap	bap	PROPN
admet-169	105	14	abp	abp	PROPN
admet-169	105	15	app	app	PROPN
admet-169	105	16	app	app	PROPN
admet-169	105	17			PROPN
admet-169	105	18			VERB
admet-169	106	1			DET
admet-169	106	2	efflux	efflux	NOUN
admet-169	106	3	ratios	ratio	NOUN
admet-169	106	4	>	>	X
admet-169	106	5	1	1	NUM
admet-169	106	6	indicate	indicate	VERB
admet-169	106	7	that	that	SCONJ
admet-169	106	8	drug	drug	NOUN
admet-169	106	9	efflux	efflux	NOUN
admet-169	106	10	occurred	occur	VERB
admet-169	106	11	during	during	ADP
admet-169	106	12	the	the	DET
admet-169	106	13	drug	drug	NOUN
admet-169	106	14	transport	transport	NOUN
admet-169	106	15	experiment	experiment	NOUN
admet-169	106	16	.	.	PUNCT
admet-169	107	1	the	the	DET
admet-169	107	2	papp	papp	NOUN
admet-169	107	3	ratios	ratio	NOUN
admet-169	107	4	are	be	AUX
admet-169	107	5	shown	show	VERB
admet-169	107	6	as	as	ADP
admet-169	107	7	a	a	DET
admet-169	107	8	mean	mean	ADJ
admet-169	107	9	value	value	NOUN
admet-169	107	10	of	of	ADP
admet-169	107	11	three	three	NUM
admet-169	107	12	or	or	CCONJ
admet-169	107	13	more	more	ADJ
admet-169	107	14	measurements	measurement	NOUN
admet-169	107	15	±	±	NUM
admet-169	107	16	sem	sem	NOUN
admet-169	107	17	.	.	PUNCT
admet-169	108	1	statistical	statistical	ADJ
admet-169	108	2	significance	significance	NOUN
admet-169	108	3	was	be	AUX
admet-169	108	4	determined	determine	VERB
admet-169	108	5	using	use	VERB
admet-169	108	6	a	a	DET
admet-169	108	7	simple	simple	ADJ
admet-169	108	8	student	student	NOUN
admet-169	108	9	’s	’s	PART
admet-169	108	10	t	t	PROPN
admet-169	108	11	-	-	PUNCT
admet-169	108	12	test	test	NOUN
admet-169	108	13	where	where	SCONJ
admet-169	108	14	a	a	DET
admet-169	108	15	p	p	NOUN
admet-169	108	16	value	value	NOUN
admet-169	108	17	of	of	ADP
admet-169	108	18	<	<	X
admet-169	108	19	0.05	0.05	NUM
admet-169	108	20	was	be	AUX
admet-169	108	21	considered	consider	VERB
admet-169	108	22	significant	significant	ADJ
admet-169	108	23	.	.	PUNCT
admet-169	109	1	results	result	NOUN
admet-169	109	2	and	and	CCONJ
admet-169	109	3	discussion	discussion	NOUN
admet-169	109	4	methodology	methodology	NOUN
admet-169	109	5	development	development	NOUN
admet-169	109	6	drug	drug	NOUN
admet-169	109	7	concentration	concentration	NOUN
admet-169	109	8	to	to	PART
admet-169	109	9	establish	establish	VERB
admet-169	109	10	a	a	DET
admet-169	109	11	baseline	baseline	NOUN
admet-169	109	12	for	for	ADP
admet-169	109	13	the	the	DET
admet-169	109	14	proposed	propose	VERB
admet-169	109	15	transwell	transwell	NOUN
admet-169	109	16	transport	transport	NOUN
admet-169	109	17	studies	study	NOUN
admet-169	109	18	a	a	DET
admet-169	109	19	plate	plate	NOUN
admet-169	109	20	with	with	ADP
admet-169	109	21	no	no	DET
admet-169	109	22	prepared	prepared	ADJ
admet-169	109	23	monolayer	monolayer	NOUN
admet-169	109	24	was	be	AUX
admet-169	109	25	used	use	VERB
admet-169	109	26	as	as	ADP
admet-169	109	27	a	a	DET
admet-169	109	28	control	control	NOUN
admet-169	109	29	system	system	NOUN
admet-169	109	30	.	.	PUNCT
admet-169	110	1	either	either	CCONJ
admet-169	110	2	erlotinib	erlotinib	NOUN
admet-169	110	3	or	or	CCONJ
admet-169	110	4	gefitinib	gefitinib	NOUN
admet-169	110	5	was	be	AUX
admet-169	110	6	placed	place	VERB
admet-169	110	7	in	in	ADP
admet-169	110	8	the	the	DET
admet-169	110	9	donor	donor	NOUN
admet-169	110	10	compartment	compartment	NOUN
admet-169	110	11	dissolved	dissolve	VERB
admet-169	110	12	in	in	ADP
admet-169	110	13	medium	medium	NOUN
admet-169	110	14	.	.	PUNCT
admet-169	111	1	however	however	ADV
admet-169	111	2	,	,	PUNCT
admet-169	111	3	control	control	NOUN
admet-169	111	4	samples	sample	NOUN
admet-169	111	5	taken	take	VERB
admet-169	111	6	from	from	ADP
admet-169	111	7	the	the	DET
admet-169	111	8	donor	donor	NOUN
admet-169	111	9	compartment	compartment	NOUN
admet-169	111	10	medium	medium	NOUN
admet-169	111	11	revealed	reveal	VERB
admet-169	111	12	a	a	DET
admet-169	111	13	curious	curious	ADJ
admet-169	111	14	decrease	decrease	NOUN
admet-169	111	15	in	in	ADP
admet-169	111	16	concentration	concentration	NOUN
admet-169	111	17	over	over	ADP
admet-169	111	18	time	time	NOUN
admet-169	111	19	(	(	PUNCT
admet-169	111	20	table	table	NOUN
admet-169	111	21	1	1	NUM
admet-169	111	22	)	)	PUNCT
admet-169	111	23	.	.	PUNCT
admet-169	112	1	a	a	DET
admet-169	112	2	drug	drug	NOUN
admet-169	112	3	concentration	concentration	NOUN
admet-169	112	4	of	of	ADP
admet-169	112	5	20	20	NUM
admet-169	112	6	µm	µm	NOUN
admet-169	112	7	had	have	AUX
admet-169	112	8	been	be	AUX
admet-169	112	9	added	add	VERB
admet-169	112	10	to	to	ADP
admet-169	112	11	the	the	DET
admet-169	112	12	donor	donor	NOUN
admet-169	112	13	compartment	compartment	NOUN
admet-169	112	14	,	,	PUNCT
admet-169	112	15	but	but	CCONJ
admet-169	112	16	the	the	DET
admet-169	112	17	actual	actual	ADJ
admet-169	112	18	concentration	concentration	NOUN
admet-169	112	19	measured	measure	VERB
admet-169	112	20	after	after	SCONJ
admet-169	112	21	the	the	DET
admet-169	112	22	3	3	NUM
admet-169	112	23	hr	hr	NOUN
admet-169	112	24	experiment	experiment	NOUN
admet-169	112	25	was	be	AUX
admet-169	112	26	repeatedly	repeatedly	ADV
admet-169	112	27	lower	low	ADJ
admet-169	112	28	than	than	SCONJ
admet-169	112	29	expected	expect	VERB
admet-169	112	30	,	,	PUNCT
admet-169	112	31	gefitinib	gefitinib	NOUN
admet-169	112	32	by	by	ADP
admet-169	112	33	1.5	1.5	NUM
admet-169	112	34	fold	fold	NOUN
admet-169	112	35	and	and	CCONJ
admet-169	112	36	erlotinib	erlotinib	NOUN
admet-169	112	37	by	by	ADP
admet-169	112	38	2	2	NUM
admet-169	112	39	to	to	PART
admet-169	112	40	3	3	NUM
admet-169	112	41	fold	fold	NOUN
admet-169	112	42	.	.	PUNCT
admet-169	113	1	the	the	DET
admet-169	113	2	observed	observed	ADJ
admet-169	113	3	decrease	decrease	NOUN
admet-169	113	4	was	be	AUX
admet-169	113	5	not	not	PART
admet-169	113	6	related	relate	VERB
admet-169	113	7	to	to	ADP
admet-169	113	8	the	the	DET
admet-169	113	9	added	add	VERB
admet-169	113	10	stock	stock	NOUN
admet-169	113	11	solution	solution	NOUN
admet-169	113	12	since	since	SCONJ
admet-169	113	13	analysis	analysis	NOUN
admet-169	113	14	of	of	ADP
admet-169	113	15	this	this	PRON
admet-169	113	16	gave	give	VERB
admet-169	113	17	the	the	DET
admet-169	113	18	correct	correct	ADJ
admet-169	113	19	concentration	concentration	NOUN
admet-169	113	20	and	and	CCONJ
admet-169	113	21	the	the	DET
admet-169	113	22	amount	amount	NOUN
admet-169	113	23	transported	transport	VERB
admet-169	113	24	to	to	ADP
admet-169	113	25	the	the	DET
admet-169	113	26	receiver	receiver	ADJ
admet-169	113	27	compartment	compartment	NOUN
admet-169	113	28	was	be	AUX
admet-169	113	29	negligible	negligible	ADJ
admet-169	113	30	compared	compare	VERB
admet-169	113	31	to	to	ADP
admet-169	113	32	the	the	DET
admet-169	113	33	change	change	NOUN
admet-169	113	34	observed	observe	VERB
admet-169	113	35	.	.	PUNCT
admet-169	114	1	tkis	tkis	NOUN
admet-169	114	2	of	of	ADP
admet-169	114	3	this	this	DET
admet-169	114	4	type	type	NOUN
admet-169	114	5	are	be	AUX
admet-169	114	6	extremely	extremely	ADV
admet-169	114	7	insoluble	insoluble	ADJ
admet-169	114	8	in	in	ADP
admet-169	114	9	aqueous	aqueous	ADJ
admet-169	114	10	solutions	solution	NOUN
admet-169	114	11	(	(	PUNCT
admet-169	114	12	hbss	hbss	NOUN
admet-169	114	13	buffer	buffer	NOUN
admet-169	114	14	in	in	ADP
admet-169	114	15	this	this	DET
admet-169	114	16	instance	instance	NOUN
admet-169	114	17	)	)	PUNCT
admet-169	114	18	and	and	CCONJ
admet-169	114	19	are	be	AUX
admet-169	114	20	known	know	VERB
admet-169	114	21	systemically	systemically	ADV
admet-169	114	22	to	to	PART
admet-169	114	23	be	be	AUX
admet-169	114	24	90	90	NUM
admet-169	114	25	–	–	SYM
admet-169	114	26	100	100	NUM
admet-169	114	27	%	%	NOUN
admet-169	114	28	bound	bind	VERB
admet-169	114	29	to	to	PART
admet-169	114	30	plasma	plasma	VERB
admet-169	114	31	protein	protein	NOUN
admet-169	114	32	[	[	X
admet-169	114	33	6	6	NUM
admet-169	114	34	]	]	PUNCT
admet-169	114	35	.	.	PUNCT
admet-169	115	1	therefore	therefore	ADV
admet-169	115	2	it	it	PRON
admet-169	115	3	was	be	AUX
admet-169	115	4	investigated	investigate	VERB
admet-169	115	5	whether	whether	SCONJ
admet-169	115	6	the	the	DET
admet-169	115	7	drug	drug	NOUN
admet-169	115	8	solubility	solubility	NOUN
admet-169	115	9	was	be	AUX
admet-169	115	10	the	the	DET
admet-169	115	11	issue	issue	NOUN
admet-169	115	12	behind	behind	ADP
admet-169	115	13	the	the	DET
admet-169	115	14	decreasing	decrease	VERB
admet-169	115	15	drug	drug	NOUN
admet-169	115	16	concentrations	concentration	NOUN
admet-169	115	17	.	.	PUNCT
admet-169	116	1	analysis	analysis	NOUN
admet-169	116	2	of	of	ADP
admet-169	116	3	drug	drug	NOUN
admet-169	116	4	concentration	concentration	NOUN
admet-169	116	5	in	in	ADP
admet-169	116	6	the	the	DET
admet-169	116	7	prepared	prepare	VERB
admet-169	116	8	medium	medium	NOUN
admet-169	116	9	immediately	immediately	ADV
admet-169	116	10	after	after	SCONJ
admet-169	116	11	dilution	dilution	NOUN
admet-169	116	12	showed	show	VERB
admet-169	116	13	concentrations	concentration	NOUN
admet-169	116	14	in	in	ADP
admet-169	116	15	the	the	DET
admet-169	116	16	20	20	NUM
admet-169	116	17	-	-	SYM
admet-169	116	18	21	21	NUM
admet-169	116	19	µm	µm	ADP
admet-169	116	20	range	range	NOUN
admet-169	116	21	.	.	PUNCT
admet-169	117	1	table	table	NOUN
admet-169	117	2	1	1	NUM
admet-169	117	3	.	.	PUNCT
admet-169	117	4	apical	apical	ADJ
admet-169	117	5	concentrations	concentration	NOUN
admet-169	117	6	of	of	ADP
admet-169	117	7	erlotinib	erlotinib	NOUN
admet-169	117	8	and	and	CCONJ
admet-169	117	9	gefitinib	gefitinib	NOUN
admet-169	117	10	(	(	PUNCT
admet-169	117	11	without	without	ADP
admet-169	117	12	bsa	bsa	NOUN
admet-169	117	13	)	)	PUNCT
admet-169	117	14	after	after	ADP
admet-169	117	15	0	0	NUM
admet-169	117	16	and	and	CCONJ
admet-169	117	17	3	3	NUM
admet-169	117	18	h	h	NOUN
admet-169	117	19	’s	’s	X
admet-169	117	20	in	in	ADP
admet-169	117	21	medium	medium	NOUN
admet-169	117	22	under	under	ADP
admet-169	117	23	standard	standard	ADJ
admet-169	117	24	conditions	condition	NOUN
admet-169	117	25	of	of	ADP
admet-169	117	26	37	37	NUM
admet-169	117	27	°	°	NOUN
admet-169	117	28	c	c	NOUN
admet-169	117	29	,	,	PUNCT
admet-169	117	30	5	5	NUM
admet-169	117	31	%	%	NOUN
admet-169	117	32	co2	co2	NOUN
admet-169	117	33	and	and	CCONJ
admet-169	117	34	100	100	NUM
admet-169	117	35	%	%	NOUN
admet-169	117	36	humidity	humidity	NOUN
admet-169	117	37	(	(	PUNCT
admet-169	117	38	n=4	n=4	NOUN
admet-169	117	39	)	)	PUNCT
admet-169	117	40	.	.	PUNCT
admet-169	118	1	donor	donor	NOUN
admet-169	118	2	concentration	concentration	NOUN
admet-169	118	3	(	(	PUNCT
admet-169	118	4	µm	µm	NOUN
admet-169	118	5	)	)	PUNCT
admet-169	118	6	apical	apical	ADJ
admet-169	118	7	0	0	NUM
admet-169	118	8	hour	hour	NOUN
admet-169	118	9	(	(	PUNCT
admet-169	118	10	µm	µm	NOUN
admet-169	118	11	±	±	NUM
admet-169	118	12	sem	sem	NOUN
admet-169	118	13	)	)	PUNCT
admet-169	118	14	apical	apical	ADJ
admet-169	118	15	3	3	NUM
admet-169	118	16	hour	hour	NOUN
admet-169	118	17	(	(	PUNCT
admet-169	118	18	µm	µm	NOUN
admet-169	118	19	±	±	NUM
admet-169	118	20	sem	sem	PROPN
admet-169	118	21	)	)	PUNCT
admet-169	118	22	erlotinib	erlotinib	NOUN
admet-169	118	23	20	20	NUM
admet-169	118	24	10.1	10.1	NUM
admet-169	118	25	±	±	NUM
admet-169	118	26	0.2	0.2	NUM
admet-169	118	27	7.1	7.1	NUM
admet-169	118	28	±	±	NUM
admet-169	118	29	0.03	0.03	NUM
admet-169	118	30	gefitinib	gefitinib	NOUN
admet-169	118	31	20	20	NUM
admet-169	118	32	19.2	19.2	NUM
admet-169	118	33	±	±	NUM
admet-169	118	34	0.3	0.3	NUM
admet-169	118	35	14.8	14.8	NUM
admet-169	118	36	±	±	NUM
admet-169	118	37	0.7	0.7	NUM
admet-169	118	38	however	however	ADV
admet-169	118	39	,	,	PUNCT
admet-169	118	40	the	the	DET
admet-169	118	41	same	same	ADJ
admet-169	118	42	solution	solution	NOUN
admet-169	118	43	demonstrated	demonstrate	VERB
admet-169	118	44	a	a	DET
admet-169	118	45	similar	similar	ADJ
admet-169	118	46	decrease	decrease	NOUN
admet-169	118	47	in	in	ADP
admet-169	118	48	concentration	concentration	NOUN
admet-169	118	49	after	after	ADP
admet-169	118	50	24	24	NUM
admet-169	118	51	hours	hour	NOUN
admet-169	118	52	as	as	SCONJ
admet-169	118	53	compared	compare	VERB
admet-169	118	54	to	to	ADP
admet-169	118	55	the	the	DET
admet-169	118	56	3	3	NUM
admet-169	118	57	hours	hour	NOUN
admet-169	118	58	post	post	NOUN
admet-169	118	59	experimental	experimental	ADJ
admet-169	118	60	sample	sample	NOUN
admet-169	118	61	.	.	PUNCT
admet-169	119	1	the	the	DET
admet-169	119	2	lowering	lowering	NOUN
admet-169	119	3	of	of	ADP
admet-169	119	4	the	the	DET
admet-169	119	5	tkis	tkis	NOUN
admet-169	119	6	’	'	PUNCT
admet-169	119	7	concentration	concentration	NOUN
admet-169	119	8	was	be	AUX
admet-169	119	9	investigated	investigate	VERB
admet-169	119	10	by	by	ADP
admet-169	119	11	lc	lc	NOUN
admet-169	119	12	-	-	PUNCT
admet-169	119	13	ms/	ms/	NOUN
admet-169	119	14	ms	ms	NOUN
admet-169	119	15	and	and	CCONJ
admet-169	119	16	complexes	complex	NOUN
admet-169	119	17	were	be	AUX
admet-169	119	18	observed	observe	VERB
admet-169	119	19	that	that	PRON
admet-169	119	20	could	could	AUX
admet-169	119	21	be	be	AUX
admet-169	119	22	linked	link	VERB
admet-169	119	23	to	to	ADP
admet-169	119	24	the	the	DET
admet-169	119	25	chelation	chelation	NOUN
admet-169	119	26	of	of	ADP
admet-169	119	27	the	the	DET
admet-169	119	28	tkis	tkis	NOUN
admet-169	119	29	to	to	ADP
admet-169	119	30	the	the	DET
admet-169	119	31	metal	metal	NOUN
admet-169	119	32	ions	ion	NOUN
admet-169	119	33	in	in	ADP
admet-169	119	34	the	the	DET
admet-169	119	35	hbss	hbss	NOUN
admet-169	119	36	buffer	buffer	NOUN
admet-169	119	37	,	,	PUNCT
admet-169	119	38	mg2	mg2	PROPN
admet-169	119	39	+	+	PROPN
admet-169	119	40	and	and	CCONJ
admet-169	119	41	ca2	ca2	PROPN
admet-169	119	42	+	+	CCONJ
admet-169	119	43	(	(	PUNCT
admet-169	119	44	data	datum	NOUN
admet-169	119	45	not	not	PART
admet-169	119	46	shown	show	VERB
admet-169	119	47	)	)	PUNCT
admet-169	119	48	.	.	PUNCT
admet-169	120	1	it	it	PRON
admet-169	120	2	was	be	AUX
admet-169	120	3	determined	determine	VERB
admet-169	120	4	that	that	SCONJ
admet-169	120	5	admet	admet	PROPN
admet-169	120	6	&	&	CCONJ
admet-169	120	7	dmpk	dmpk	PROPN
admet-169	120	8	3(1	3(1	NUM
admet-169	120	9	)	)	PUNCT
admet-169	120	10	(	(	PUNCT
admet-169	120	11	2015	2015	NUM
admet-169	120	12	)	)	PUNCT
admet-169	120	13	51	51	NUM
admet-169	120	14	-	-	SYM
admet-169	120	15	67	67	NUM
admet-169	120	16	adaptation	adaptation	NOUN
admet-169	120	17	of	of	ADP
admet-169	120	18	human	human	ADJ
admet-169	120	19	gut	gut	NOUN
admet-169	120	20	epithelial	epithelial	ADJ
admet-169	120	21	model	model	NOUN
admet-169	120	22	doi	doi	NOUN
admet-169	120	23	:	:	PUNCT
admet-169	120	24	10.5599	10.5599	NUM
admet-169	120	25	/	/	SYM
admet-169	120	26	admet.3.1.169	admet.3.1.169	PROPN
admet-169	120	27	57	57	NUM
admet-169	120	28	these	these	DET
admet-169	120	29	compounds	compound	NOUN
admet-169	120	30	will	will	AUX
admet-169	120	31	form	form	VERB
admet-169	120	32	chelation	chelation	NOUN
admet-169	120	33	complexes	complex	NOUN
admet-169	120	34	in	in	ADP
admet-169	120	35	the	the	DET
admet-169	120	36	ratios	ratio	NOUN
admet-169	120	37	2:3	2:3	NUM
admet-169	120	38	for	for	ADP
admet-169	120	39	gefitinib	gefitinib	NOUN
admet-169	120	40	and	and	CCONJ
admet-169	120	41	1:2	1:2	NUM
admet-169	120	42	for	for	ADP
admet-169	120	43	erlotinib	erlotinib	NOUN
admet-169	120	44	,	,	PUNCT
admet-169	120	45	these	these	DET
admet-169	120	46	complexes	complex	NOUN
admet-169	120	47	were	be	AUX
admet-169	120	48	not	not	PART
admet-169	120	49	broken	break	VERB
admet-169	120	50	up	up	ADP
admet-169	120	51	during	during	ADP
admet-169	120	52	sample	sample	NOUN
admet-169	120	53	preparation	preparation	NOUN
admet-169	120	54	and	and	CCONJ
admet-169	120	55	hence	hence	ADV
admet-169	120	56	the	the	DET
admet-169	120	57	relative	relative	ADJ
admet-169	120	58	concentration	concentration	NOUN
admet-169	120	59	of	of	ADP
admet-169	120	60	drug	drug	NOUN
admet-169	120	61	appears	appear	VERB
admet-169	120	62	to	to	PART
admet-169	120	63	decrease	decrease	VERB
admet-169	120	64	over	over	ADP
admet-169	120	65	time	time	NOUN
admet-169	120	66	.	.	PUNCT
admet-169	121	1	to	to	PART
admet-169	121	2	prevent	prevent	VERB
admet-169	121	3	chelation	chelation	NOUN
admet-169	121	4	,	,	PUNCT
admet-169	121	5	bovine	bovine	NOUN
admet-169	121	6	serum	serum	NOUN
admet-169	121	7	albumin	albumin	PROPN
admet-169	121	8	(	(	PUNCT
admet-169	121	9	bsa	bsa	PROPN
admet-169	121	10	)	)	PUNCT
admet-169	121	11	was	be	AUX
admet-169	121	12	added	add	VERB
admet-169	121	13	to	to	ADP
admet-169	121	14	the	the	DET
admet-169	121	15	transport	transport	NOUN
admet-169	121	16	medium	medium	NOUN
admet-169	121	17	at	at	ADP
admet-169	121	18	a	a	DET
admet-169	121	19	concentration	concentration	NOUN
admet-169	121	20	of	of	ADP
admet-169	121	21	5	5	NUM
admet-169	121	22	%	%	NOUN
admet-169	121	23	v	v	ADP
admet-169	121	24	/	/	SYM
admet-169	121	25	v	v	NOUN
admet-169	121	26	,	,	PUNCT
admet-169	121	27	subsequently	subsequently	ADV
admet-169	121	28	measured	measure	VERB
admet-169	121	29	concentrations	concentration	NOUN
admet-169	121	30	after	after	ADP
admet-169	121	31	3	3	NUM
admet-169	121	32	hours	hour	NOUN
admet-169	121	33	at	at	ADP
admet-169	121	34	37	37	NUM
admet-169	121	35	°	°	NOUN
admet-169	121	36	c	c	NOUN
admet-169	121	37	matched	match	VERB
admet-169	121	38	the	the	DET
admet-169	121	39	expected	expect	VERB
admet-169	121	40	concentration	concentration	NOUN
admet-169	121	41	of	of	ADP
admet-169	121	42	20	20	NUM
admet-169	121	43	µm	µm	NOUN
admet-169	121	44	for	for	ADP
admet-169	121	45	both	both	DET
admet-169	121	46	erlotinib	erlotinib	NOUN
admet-169	121	47	and	and	CCONJ
admet-169	121	48	gefitinib	gefitinib	NOUN
admet-169	121	49	(	(	PUNCT
admet-169	121	50	figure	figure	NOUN
admet-169	121	51	3	3	NUM
admet-169	121	52	)	)	PUNCT
admet-169	121	53	.	.	PUNCT
admet-169	122	1	in	in	ADP
admet-169	122	2	addition	addition	NOUN
admet-169	122	3	,	,	PUNCT
admet-169	122	4	it	it	PRON
admet-169	122	5	was	be	AUX
admet-169	122	6	also	also	ADV
admet-169	122	7	determined	determined	ADJ
admet-169	122	8	that	that	SCONJ
admet-169	122	9	the	the	DET
admet-169	122	10	addition	addition	NOUN
admet-169	122	11	of	of	ADP
admet-169	122	12	nan3	nan3	PROPN
admet-169	122	13	or	or	CCONJ
admet-169	122	14	ko143	ko143	PROPN
admet-169	122	15	to	to	ADP
admet-169	122	16	the	the	DET
admet-169	122	17	transport	transport	NOUN
admet-169	122	18	medium	medium	NOUN
admet-169	122	19	did	do	AUX
admet-169	122	20	not	not	PART
admet-169	122	21	significantly	significantly	ADV
admet-169	122	22	affect	affect	VERB
admet-169	122	23	the	the	DET
admet-169	122	24	initial	initial	ADJ
admet-169	122	25	and	and	CCONJ
admet-169	122	26	post	post	VERB
admet-169	122	27	donor	donor	NOUN
admet-169	122	28	concentrations	concentration	NOUN
admet-169	122	29	of	of	ADP
admet-169	122	30	either	either	CCONJ
admet-169	122	31	erlotinib	erlotinib	NOUN
admet-169	122	32	or	or	CCONJ
admet-169	122	33	gefitinib	gefitinib	NOUN
admet-169	122	34	when	when	SCONJ
admet-169	122	35	5	5	NUM
admet-169	122	36	%	%	NOUN
admet-169	122	37	bsa	bsa	PROPN
admet-169	122	38	was	be	AUX
admet-169	122	39	added	add	VERB
admet-169	122	40	.	.	PUNCT
admet-169	123	1	c	c	NOUN
admet-169	124	1	o	o	NOUN
admet-169	124	2	n	n	ADP
admet-169	124	3	c	c	NOUN
admet-169	124	4	e	e	X
admet-169	124	5	n	n	X
admet-169	124	6	tr	tr	DET
admet-169	124	7	a	a	DET
admet-169	124	8	ti	ti	NOUN
admet-169	124	9	o	o	NOUN
admet-169	124	10	n	n	PROPN
admet-169	124	11	(	(	PUNCT
admet-169	124	12	µ	µ	X
admet-169	124	13	m	m	NOUN
admet-169	124	14	)	)	PUNCT
admet-169	125	1	w	w	PROPN
admet-169	125	2	ith	ith	PROPN
admet-169	125	3	out	out	ADP
admet-169	125	4	b	b	PROPN
admet-169	125	5	s	s	PROPN
admet-169	125	6	a	a	PRON
admet-169	125	7	w	w	PROPN
admet-169	125	8	ith	ith	PROPN
admet-169	125	9	b	b	PROPN
admet-169	125	10	sa	sa	PROPN
admet-169	125	11	w	w	PROPN
admet-169	125	12	ith	ith	PROPN
admet-169	125	13	b	b	PROPN
admet-169	125	14	sa	sa	PROPN
admet-169	126	1	+	+	PROPN
admet-169	126	2	k	k	PROPN
admet-169	126	3	o14	o14	NOUN
admet-169	126	4	3	3	NUM
admet-169	126	5	w	w	PROPN
admet-169	126	6	ith	ith	PROPN
admet-169	126	7	b	b	PROPN
admet-169	126	8	sa	sa	PROPN
admet-169	126	9	+	+	PROPN
admet-169	126	10	n	n	CCONJ
admet-169	126	11	an	an	DET
admet-169	126	12	3	3	NUM
admet-169	126	13	0	0	NUM
admet-169	126	14	10	10	NUM
admet-169	126	15	20	20	NUM
admet-169	126	16	30	30	NUM
admet-169	126	17	erlotinib	erlotinib	NOUN
admet-169	126	18	gefitinib	gefitinib	NOUN
admet-169	126	19	figure	figure	VERB
admet-169	126	20	3	3	NUM
admet-169	126	21	.	.	NOUN
admet-169	126	22	comparison	comparison	NOUN
admet-169	126	23	of	of	ADP
admet-169	126	24	the	the	DET
admet-169	126	25	concentration	concentration	NOUN
admet-169	126	26	determined	determine	VERB
admet-169	126	27	for	for	ADP
admet-169	126	28	prepared	prepared	ADJ
admet-169	126	29	20	20	NUM
admet-169	126	30	µm	µm	ADP
admet-169	126	31	solutions	solution	NOUN
admet-169	126	32	of	of	ADP
admet-169	126	33	erlotinib	erlotinib	NOUN
admet-169	126	34	or	or	CCONJ
admet-169	126	35	gefitinib	gefitinib	NOUN
admet-169	126	36	in	in	ADP
admet-169	126	37	hbss	hbss	NOUN
admet-169	126	38	buffer	buffer	NOUN
admet-169	126	39	after	after	ADP
admet-169	126	40	3	3	NUM
admet-169	126	41	hours	hour	NOUN
admet-169	126	42	at	at	ADP
admet-169	126	43	37	37	NUM
admet-169	126	44	°	°	NOUN
admet-169	126	45	c	c	NOUN
admet-169	126	46	with	with	ADP
admet-169	126	47	and	and	CCONJ
admet-169	126	48	without	without	ADP
admet-169	126	49	5	5	NUM
admet-169	126	50	%	%	NOUN
admet-169	126	51	bovine	bovine	NOUN
admet-169	126	52	serum	serum	NOUN
admet-169	126	53	album	album	NOUN
admet-169	126	54	–	–	PUNCT
admet-169	126	55	(	(	PUNCT
admet-169	126	56	bsa	bsa	PROPN
admet-169	126	57	)	)	PUNCT
admet-169	126	58	.	.	PUNCT
admet-169	127	1	addition	addition	NOUN
admet-169	127	2	of	of	ADP
admet-169	127	3	bsa	bsa	PROPN
admet-169	127	4	prevented	prevent	VERB
admet-169	127	5	chelation	chelation	NOUN
admet-169	127	6	of	of	ADP
admet-169	127	7	both	both	DET
admet-169	127	8	erlotinib	erlotinib	NOUN
admet-169	127	9	and	and	CCONJ
admet-169	127	10	gefitinib	gefitinib	NOUN
admet-169	127	11	during	during	ADP
admet-169	127	12	the	the	DET
admet-169	127	13	course	course	NOUN
admet-169	127	14	of	of	ADP
admet-169	127	15	the	the	DET
admet-169	127	16	3	3	NUM
admet-169	127	17	hour	hour	NOUN
admet-169	127	18	experimental	experimental	ADJ
admet-169	127	19	procedure	procedure	NOUN
admet-169	127	20	which	which	PRON
admet-169	127	21	was	be	AUX
admet-169	127	22	not	not	PART
admet-169	127	23	affected	affect	VERB
admet-169	127	24	by	by	ADP
admet-169	127	25	the	the	DET
admet-169	127	26	addition	addition	NOUN
admet-169	127	27	of	of	ADP
admet-169	127	28	ko143	ko143	NOUN
admet-169	127	29	or	or	CCONJ
admet-169	127	30	sodium	sodium	NOUN
admet-169	127	31	azide	azide	NOUN
admet-169	127	32	.	.	PUNCT
admet-169	128	1	(	(	PUNCT
admet-169	128	2	µm	µm	NOUN
admet-169	128	3	±	±	NUM
admet-169	128	4	sem	sem	NOUN
admet-169	128	5	of	of	ADP
admet-169	128	6	n=16	n=16	NOUN
admet-169	128	7	)	)	PUNCT
admet-169	128	8	.	.	PUNCT
admet-169	129	1	using	use	VERB
admet-169	129	2	these	these	DET
admet-169	129	3	conditions	condition	NOUN
admet-169	129	4	the	the	DET
admet-169	129	5	transport	transport	NOUN
admet-169	129	6	over	over	ADP
admet-169	129	7	the	the	DET
admet-169	129	8	blank	blank	ADJ
admet-169	129	9	transwell	transwell	NOUN
admet-169	129	10	system	system	NOUN
admet-169	129	11	(	(	PUNCT
admet-169	129	12	no	no	DET
admet-169	129	13	-	-	PUNCT
admet-169	129	14	monolayer	monolayer	NOUN
admet-169	129	15	)	)	PUNCT
admet-169	129	16	was	be	AUX
admet-169	129	17	determined	determine	VERB
admet-169	129	18	.	.	PUNCT
admet-169	130	1	samples	sample	NOUN
admet-169	130	2	were	be	AUX
admet-169	130	3	taken	take	VERB
admet-169	130	4	from	from	ADP
admet-169	130	5	the	the	DET
admet-169	130	6	receiver	receiver	ADJ
admet-169	130	7	compartment	compartment	NOUN
admet-169	130	8	on	on	ADP
admet-169	130	9	the	the	DET
admet-169	130	10	same	same	ADJ
admet-169	130	11	time	time	NOUN
admet-169	130	12	schedule	schedule	NOUN
admet-169	130	13	as	as	ADP
admet-169	130	14	the	the	DET
admet-169	130	15	proposed	propose	VERB
admet-169	130	16	experimental	experimental	ADJ
admet-169	130	17	procedure	procedure	NOUN
admet-169	130	18	.	.	PUNCT
admet-169	131	1	figure	figure	NOUN
admet-169	131	2	4	4	NUM
admet-169	131	3	shows	show	VERB
admet-169	131	4	the	the	DET
admet-169	131	5	graphical	graphical	ADJ
admet-169	131	6	representation	representation	NOUN
admet-169	131	7	of	of	ADP
admet-169	131	8	the	the	DET
admet-169	131	9	transport	transport	NOUN
admet-169	131	10	characteristics	characteristic	NOUN
admet-169	131	11	of	of	ADP
admet-169	131	12	gefitinib	gefitinib	NOUN
admet-169	131	13	under	under	ADP
admet-169	131	14	these	these	DET
admet-169	131	15	conditions	condition	NOUN
admet-169	131	16	.	.	PUNCT
admet-169	132	1	linear	linear	ADJ
admet-169	132	2	transport	transport	NOUN
admet-169	132	3	characteristics	characteristic	NOUN
admet-169	132	4	are	be	AUX
admet-169	132	5	observed	observe	VERB
admet-169	132	6	with	with	ADP
admet-169	132	7	both	both	DET
admet-169	132	8	conditions	condition	NOUN
admet-169	132	9	.	.	PUNCT
admet-169	133	1	post	post	NOUN
admet-169	133	2	experiment	experiment	NOUN
admet-169	133	3	each	each	DET
admet-169	133	4	donor	donor	NOUN
admet-169	134	1	well	well	ADV
admet-169	134	2	was	be	AUX
admet-169	134	3	drained	drain	VERB
admet-169	134	4	and	and	CCONJ
admet-169	134	5	washed	wash	VERB
admet-169	134	6	three	three	NUM
admet-169	134	7	times	time	NOUN
admet-169	134	8	with	with	ADP
admet-169	134	9	fresh	fresh	ADJ
admet-169	134	10	medium	medium	NOUN
admet-169	134	11	.	.	PUNCT
admet-169	135	1	using	use	VERB
admet-169	135	2	a	a	DET
admet-169	135	3	1	1	NUM
admet-169	135	4	%	%	NOUN
admet-169	135	5	dmso	dmso	ADJ
admet-169	135	6	solution	solution	NOUN
admet-169	135	7	of	of	ADP
admet-169	135	8	ethanol	ethanol	NOUN
admet-169	135	9	each	each	DET
admet-169	135	10	used	use	VERB
admet-169	135	11	compartment	compartment	NOUN
admet-169	135	12	was	be	AUX
admet-169	135	13	washed	wash	VERB
admet-169	135	14	and	and	CCONJ
admet-169	135	15	the	the	DET
admet-169	135	16	effluent	effluent	NOUN
admet-169	135	17	collected	collect	VERB
admet-169	135	18	.	.	PUNCT
admet-169	136	1	analysis	analysis	NOUN
admet-169	136	2	of	of	ADP
admet-169	136	3	the	the	DET
admet-169	136	4	effluent	effluent	NOUN
admet-169	136	5	revealed	reveal	VERB
admet-169	136	6	no	no	DET
admet-169	136	7	evidence	evidence	NOUN
admet-169	136	8	gefitinib	gefitinib	NOUN
admet-169	136	9	remaining	remain	VERB
admet-169	136	10	on	on	ADP
admet-169	136	11	the	the	DET
admet-169	136	12	compartment	compartment	NOUN
admet-169	136	13	surfaces	surface	NOUN
admet-169	136	14	(	(	PUNCT
admet-169	136	15	data	datum	NOUN
admet-169	136	16	not	not	PART
admet-169	136	17	shown	show	VERB
admet-169	136	18	)	)	PUNCT
admet-169	136	19	.	.	PUNCT
admet-169	137	1	peters	peters	PROPN
admet-169	137	2	et	et	PROPN
admet-169	137	3	al	al	PROPN
admet-169	137	4	.	.	PROPN
admet-169	137	5	admet	admet	PROPN
admet-169	137	6	&	&	CCONJ
admet-169	137	7	dmpk	dmpk	PROPN
admet-169	137	8	3(1	3(1	NUM
admet-169	137	9	)	)	PUNCT
admet-169	137	10	(	(	PUNCT
admet-169	137	11	2015	2015	NUM
admet-169	137	12	)	)	PUNCT
admet-169	137	13	51	51	NUM
admet-169	137	14	-	-	SYM
admet-169	137	15	67	67	NUM
admet-169	137	16	58	58	NUM
admet-169	137	17	transwell	transwell	NOUN
admet-169	137	18	monolayer	monolayer	NOUN
admet-169	137	19	reproducibility	reproducibility	NOUN
admet-169	137	20	cells	cell	NOUN
admet-169	137	21	were	be	AUX
admet-169	137	22	prepared	prepare	VERB
admet-169	137	23	as	as	ADP
admet-169	137	24	a	a	DET
admet-169	137	25	monolayer	monolayer	NOUN
admet-169	137	26	using	use	VERB
admet-169	137	27	a	a	DET
admet-169	137	28	3	3	NUM
admet-169	137	29	-	-	PUNCT
admet-169	137	30	day	day	NOUN
admet-169	137	31	culture	culture	NOUN
admet-169	137	32	protocol	protocol	NOUN
admet-169	137	33	by	by	ADP
admet-169	137	34	yamashita	yamashita	PROPN
admet-169	137	35	et	et	PROPN
admet-169	137	36	al	al	PROPN
admet-169	138	1	[	[	X
admet-169	138	2	24	24	NUM
admet-169	138	3	]	]	PUNCT
admet-169	138	4	supplied	supply	VERB
admet-169	138	5	as	as	ADP
admet-169	138	6	a	a	DET
admet-169	138	7	commercial	commercial	ADJ
admet-169	138	8	kit	kit	NOUN
admet-169	138	9	by	by	ADP
admet-169	138	10	becton	becton	PROPN
admet-169	138	11	dickinson	dickinson	PROPN
admet-169	138	12	bv	bv	PROPN
admet-169	138	13	(	(	PUNCT
admet-169	138	14	the	the	DET
admet-169	138	15	netherlands	netherlands	PROPN
admet-169	138	16	)	)	PUNCT
admet-169	138	17	.	.	PUNCT
admet-169	139	1	monolayer	monolayer	NOUN
admet-169	139	2	integrity	integrity	NOUN
admet-169	139	3	was	be	AUX
admet-169	139	4	determined	determine	VERB
admet-169	139	5	by	by	ADP
admet-169	139	6	teer	teer	NOUN
admet-169	139	7	measurements	measurement	NOUN
admet-169	139	8	prior	prior	ADV
admet-169	139	9	to	to	ADP
admet-169	139	10	and	and	CCONJ
admet-169	139	11	after	after	ADP
admet-169	139	12	3	3	NUM
admet-169	139	13	hours	hour	NOUN
admet-169	139	14	post	post	NOUN
admet-169	139	15	addition	addition	NOUN
admet-169	139	16	of	of	ADP
admet-169	139	17	the	the	DET
admet-169	139	18	drugs	drug	NOUN
admet-169	139	19	.	.	PUNCT
admet-169	140	1	values	value	NOUN
admet-169	140	2	such	such	ADJ
admet-169	140	3	as	as	ADP
admet-169	140	4	260	260	NUM
admet-169	140	5	±	±	NOUN
admet-169	140	6	65	65	NUM
admet-169	140	7	ω	ω	NUM
admet-169	140	8	cm	cm	NOUN
admet-169	140	9	2	2	NUM
admet-169	141	1	[	[	X
admet-169	141	2	23	23	NUM
admet-169	141	3	]	]	PUNCT
admet-169	141	4	and	and	CCONJ
admet-169	141	5	300	300	NUM
admet-169	141	6	–	–	PUNCT
admet-169	141	7	600	600	NUM
admet-169	141	8	ω	ω	NUM
admet-169	141	9	cm	cm	NOUN
admet-169	141	10	2	2	NUM
admet-169	141	11	have	have	AUX
admet-169	141	12	been	be	AUX
admet-169	141	13	quoted	quote	VERB
admet-169	141	14	in	in	ADP
admet-169	141	15	literature	literature	NOUN
admet-169	141	16	as	as	ADP
admet-169	141	17	being	be	AUX
admet-169	141	18	a	a	DET
admet-169	141	19	specification	specification	NOUN
admet-169	141	20	cut	cut	NOUN
admet-169	141	21	-	-	PUNCT
admet-169	141	22	off	off	NOUN
admet-169	141	23	.	.	PUNCT
admet-169	142	1	[	[	X
admet-169	142	2	26	26	NUM
admet-169	142	3	]	]	PUNCT
admet-169	142	4	however	however	ADV
admet-169	142	5	,	,	PUNCT
admet-169	142	6	under	under	ADP
admet-169	142	7	300	300	NUM
admet-169	142	8	ω	ω	NUM
admet-169	142	9	cm	cm	NOUN
admet-169	142	10	2	2	NUM
admet-169	142	11	we	we	PRON
admet-169	142	12	observed	observe	VERB
admet-169	142	13	transport	transport	NOUN
admet-169	142	14	characteristics	characteristic	NOUN
admet-169	142	15	that	that	PRON
admet-169	142	16	were	be	AUX
admet-169	142	17	similar	similar	ADJ
admet-169	142	18	to	to	ADP
admet-169	142	19	a	a	DET
admet-169	142	20	well	well	NOUN
admet-169	142	21	with	with	ADP
admet-169	142	22	no	no	DET
admet-169	142	23	monolayer	monolayer	NOUN
admet-169	142	24	while	while	SCONJ
admet-169	142	25	above	above	ADP
admet-169	142	26	1600	1600	NUM
admet-169	142	27	ω	ω	NUM
admet-169	142	28	cm	cm	NOUN
admet-169	142	29	2	2	NUM
admet-169	142	30	transport	transport	NOUN
admet-169	142	31	characteristics	characteristic	NOUN
admet-169	142	32	were	be	AUX
admet-169	142	33	highly	highly	ADV
admet-169	142	34	different	different	ADJ
admet-169	142	35	in	in	ADP
admet-169	142	36	regards	regard	NOUN
admet-169	142	37	to	to	ADP
admet-169	142	38	mass	mass	NOUN
admet-169	142	39	transported	transport	VERB
admet-169	142	40	.	.	PUNCT
admet-169	143	1	hence	hence	ADV
admet-169	143	2	,	,	PUNCT
admet-169	143	3	the	the	DET
admet-169	143	4	specifications	specification	NOUN
admet-169	143	5	for	for	ADP
admet-169	143	6	monolayer	monolayer	NOUN
admet-169	143	7	integrity	integrity	NOUN
admet-169	143	8	was	be	AUX
admet-169	143	9	set	set	VERB
admet-169	143	10	in	in	ADP
admet-169	143	11	the	the	DET
admet-169	143	12	range	range	NOUN
admet-169	143	13	600	600	NUM
admet-169	143	14	–	–	SYM
admet-169	143	15	1600	1600	NUM
admet-169	143	16	ω	ω	NUM
admet-169	143	17	cm	cm	NOUN
admet-169	143	18	2	2	NUM
admet-169	143	19	,	,	PUNCT
admet-169	143	20	this	this	PRON
admet-169	143	21	was	be	AUX
admet-169	143	22	in	in	ADP
admet-169	143	23	agreement	agreement	NOUN
admet-169	143	24	with	with	ADP
admet-169	143	25	the	the	DET
admet-169	143	26	technical	technical	ADJ
admet-169	143	27	information	information	NOUN
admet-169	143	28	as	as	SCONJ
admet-169	143	29	supplied	supply	VERB
admet-169	143	30	by	by	ADP
admet-169	143	31	becton	becton	PROPN
admet-169	143	32	dickinson	dickinson	PROPN
admet-169	143	33	.	.	PUNCT
admet-169	144	1	initial	initial	ADJ
admet-169	144	2	teer	teer	NOUN
admet-169	144	3	values	value	NOUN
admet-169	144	4	revealed	reveal	VERB
admet-169	144	5	a	a	DET
admet-169	144	6	problem	problem	NOUN
admet-169	144	7	to	to	ADP
admet-169	144	8	the	the	DET
admet-169	144	9	formation	formation	NOUN
admet-169	144	10	of	of	ADP
admet-169	144	11	consistent	consistent	ADJ
admet-169	144	12	monolayers	monolayer	NOUN
admet-169	144	13	linked	link	VERB
admet-169	144	14	to	to	ADP
admet-169	144	15	the	the	DET
admet-169	144	16	well	well	ADJ
admet-169	144	17	position	position	NOUN
admet-169	144	18	within	within	ADP
admet-169	144	19	each	each	DET
admet-169	144	20	24	24	NUM
admet-169	144	21	well	well	NOUN
admet-169	144	22	plate	plate	NOUN
admet-169	144	23	.	.	PUNCT
admet-169	145	1	wells	well	NOUN
admet-169	145	2	closer	close	ADV
admet-169	145	3	to	to	ADP
admet-169	145	4	the	the	DET
admet-169	145	5	sides	side	NOUN
admet-169	145	6	of	of	ADP
admet-169	145	7	the	the	DET
admet-169	145	8	plate	plate	NOUN
admet-169	145	9	often	often	ADV
admet-169	145	10	had	have	VERB
admet-169	145	11	teer	teer	NOUN
admet-169	145	12	values	value	NOUN
admet-169	145	13	indicating	indicate	VERB
admet-169	145	14	an	an	DET
admet-169	145	15	incomplete	incomplete	ADJ
admet-169	145	16	monolayer	monolayer	NOUN
admet-169	145	17	,	,	PUNCT
admet-169	145	18	whereas	whereas	SCONJ
admet-169	145	19	more	more	ADV
admet-169	145	20	centrally	centrally	ADV
admet-169	145	21	placed	place	VERB
admet-169	145	22	wells	well	NOUN
admet-169	145	23	were	be	AUX
admet-169	145	24	within	within	ADP
admet-169	145	25	the	the	DET
admet-169	145	26	approved	approve	VERB
admet-169	145	27	specification	specification	NOUN
admet-169	145	28	,	,	PUNCT
admet-169	145	29	indicating	indicate	VERB
admet-169	145	30	a	a	DET
admet-169	145	31	complete	complete	ADJ
admet-169	145	32	monolayer	monolayer	NOUN
admet-169	145	33	.	.	PUNCT
admet-169	146	1	it	it	PRON
admet-169	146	2	was	be	AUX
admet-169	146	3	observed	observe	VERB
admet-169	146	4	that	that	SCONJ
admet-169	146	5	caco-2	caco-2	NUM
admet-169	146	6	monolayers	monolayer	NOUN
admet-169	146	7	were	be	AUX
admet-169	146	8	highly	highly	ADV
admet-169	146	9	sensitive	sensitive	ADJ
admet-169	146	10	to	to	ADP
admet-169	146	11	minor	minor	ADJ
admet-169	146	12	fluctuations	fluctuation	NOUN
admet-169	146	13	in	in	ADP
admet-169	146	14	temperature	temperature	NOUN
admet-169	146	15	,	,	PUNCT
admet-169	146	16	humidity	humidity	NOUN
admet-169	146	17	and	and	CCONJ
admet-169	146	18	co2	co2	NOUN
admet-169	146	19	content	content	NOUN
admet-169	146	20	;	;	PUNCT
admet-169	146	21	these	these	DET
admet-169	146	22	fluctuations	fluctuation	NOUN
admet-169	146	23	affected	affect	VERB
admet-169	146	24	individual	individual	ADJ
admet-169	146	25	wells	well	NOUN
admet-169	146	26	depending	depend	VERB
admet-169	146	27	on	on	ADP
admet-169	146	28	the	the	DET
admet-169	146	29	plate	plate	NOUN
admet-169	146	30	orientation	orientation	NOUN
admet-169	146	31	and	and	CCONJ
admet-169	146	32	position	position	NOUN
admet-169	146	33	within	within	ADP
admet-169	146	34	the	the	DET
admet-169	146	35	incubator	incubator	NOUN
admet-169	146	36	.	.	PUNCT
admet-169	147	1	to	to	PART
admet-169	147	2	regulate	regulate	VERB
admet-169	147	3	the	the	DET
admet-169	147	4	environment	environment	NOUN
admet-169	147	5	within	within	ADP
admet-169	147	6	each	each	DET
admet-169	147	7	well	well	NOUN
admet-169	147	8	a	a	DET
admet-169	147	9	breathable	breathable	ADJ
admet-169	147	10	membrane	membrane	NOUN
admet-169	147	11	seal	seal	NOUN
admet-169	147	12	was	be	AUX
admet-169	147	13	applied	apply	VERB
admet-169	147	14	,	,	PUNCT
admet-169	147	15	this	this	PRON
admet-169	147	16	was	be	AUX
admet-169	147	17	sufficient	sufficient	ADJ
admet-169	147	18	for	for	SCONJ
admet-169	147	19	reproducible	reproducible	ADJ
admet-169	147	20	monolayers	monolayer	NOUN
admet-169	147	21	across	across	ADP
admet-169	147	22	the	the	DET
admet-169	147	23	entire	entire	ADJ
admet-169	147	24	plate	plate	NOUN
admet-169	147	25	to	to	PART
admet-169	147	26	be	be	AUX
admet-169	147	27	formed	form	VERB
admet-169	147	28	within	within	ADP
admet-169	147	29	the	the	DET
admet-169	147	30	3	3	NUM
admet-169	147	31	-	-	PUNCT
admet-169	147	32	day	day	NOUN
admet-169	147	33	growth	growth	NOUN
admet-169	147	34	period	period	NOUN
admet-169	147	35	.	.	PUNCT
admet-169	148	1	an	an	DET
admet-169	148	2	additional	additional	ADJ
admet-169	148	3	problem	problem	NOUN
admet-169	148	4	was	be	AUX
admet-169	148	5	observed	observe	VERB
admet-169	148	6	with	with	ADP
admet-169	148	7	the	the	DET
admet-169	148	8	teer	teer	NOUN
admet-169	148	9	measurements	measurement	NOUN
admet-169	148	10	post	post	VERB
admet-169	148	11	experiment	experiment	NOUN
admet-169	148	12	,	,	PUNCT
admet-169	148	13	here	here	ADV
admet-169	148	14	teer	teer	NOUN
admet-169	148	15	values	value	NOUN
admet-169	148	16	of	of	ADP
admet-169	148	17	300	300	NUM
admet-169	148	18	ω	ω	NUM
admet-169	148	19	cm	cm	NOUN
admet-169	148	20	2	2	NUM
admet-169	148	21	or	or	CCONJ
admet-169	148	22	lower	low	ADJ
admet-169	148	23	were	be	AUX
admet-169	148	24	observed	observe	VERB
admet-169	148	25	indicating	indicate	VERB
admet-169	148	26	loss	loss	NOUN
admet-169	148	27	of	of	ADP
admet-169	148	28	monolayer	monolayer	NOUN
admet-169	148	29	integrity	integrity	NOUN
admet-169	148	30	at	at	ADP
admet-169	148	31	an	an	DET
admet-169	148	32	unknown	unknown	ADJ
admet-169	148	33	stage	stage	NOUN
admet-169	148	34	during	during	ADP
admet-169	148	35	the	the	DET
admet-169	148	36	experimental	experimental	ADJ
admet-169	148	37	procedure	procedure	NOUN
admet-169	148	38	.	.	PUNCT
admet-169	149	1	post	post	NOUN
admet-169	149	2	experiment	experiment	NOUN
admet-169	149	3	each	each	PRON
admet-169	149	4	well	well	ADV
admet-169	149	5	was	be	AUX
admet-169	149	6	carefully	carefully	ADV
admet-169	149	7	washed	wash	VERB
admet-169	149	8	free	free	ADJ
admet-169	149	9	of	of	ADP
admet-169	149	10	drug	drug	NOUN
admet-169	149	11	containing	contain	VERB
admet-169	149	12	medium	medium	NOUN
admet-169	149	13	with	with	ADP
admet-169	149	14	the	the	DET
admet-169	149	15	intention	intention	NOUN
admet-169	149	16	of	of	ADP
admet-169	149	17	recovering	recover	VERB
admet-169	149	18	as	as	ADV
admet-169	149	19	many	many	ADJ
admet-169	149	20	cells	cell	NOUN
admet-169	149	21	as	as	ADP
admet-169	149	22	possible	possible	ADJ
admet-169	149	23	for	for	ADP
admet-169	149	24	accumulation	accumulation	NOUN
admet-169	149	25	analysis	analysis	NOUN
admet-169	149	26	.	.	PUNCT
admet-169	150	1	additionally	additionally	ADV
admet-169	150	2	this	this	DET
admet-169	150	3	washing	washing	NOUN
admet-169	150	4	step	step	NOUN
admet-169	150	5	was	be	AUX
admet-169	150	6	included	include	VERB
admet-169	150	7	since	since	SCONJ
admet-169	150	8	it	it	PRON
admet-169	150	9	was	be	AUX
admet-169	150	10	unknown	unknown	ADJ
admet-169	150	11	whether	whether	SCONJ
admet-169	150	12	the	the	DET
admet-169	150	13	added	add	VERB
admet-169	150	14	drugs	drug	NOUN
admet-169	150	15	to	to	ADP
admet-169	150	16	the	the	DET
admet-169	150	17	medium	medium	NOUN
admet-169	150	18	would	would	AUX
admet-169	150	19	affect	affect	VERB
admet-169	150	20	the	the	DET
admet-169	150	21	teer	teer	NOUN
admet-169	150	22	measurements	measurement	NOUN
admet-169	150	23	.	.	PUNCT
admet-169	151	1	however	however	ADV
admet-169	151	2	,	,	PUNCT
admet-169	151	3	this	this	DET
admet-169	151	4	washing	washing	NOUN
admet-169	151	5	step	step	NOUN
admet-169	151	6	disrupted	disrupt	VERB
admet-169	151	7	the	the	DET
admet-169	151	8	monolayer	monolayer	NOUN
admet-169	151	9	significantly	significantly	ADV
admet-169	151	10	giving	give	VERB
admet-169	151	11	the	the	DET
admet-169	151	12	“	"	PUNCT
admet-169	151	13	out	out	ADP
admet-169	151	14	of	of	ADP
admet-169	151	15	specification	specification	NOUN
admet-169	151	16	”	"	PUNCT
admet-169	151	17	teer	teer	NOUN
admet-169	151	18	values	value	NOUN
admet-169	151	19	.	.	PUNCT
admet-169	152	1	avoiding	avoid	VERB
admet-169	152	2	the	the	DET
admet-169	152	3	final	final	ADJ
admet-169	152	4	washing	washing	NOUN
admet-169	152	5	stage	stage	NOUN
admet-169	152	6	teer	teer	NOUN
admet-169	152	7	values	value	NOUN
admet-169	152	8	demonstrated	demonstrate	VERB
admet-169	152	9	good	good	ADJ
admet-169	152	10	integrity	integrity	NOUN
admet-169	152	11	over	over	ADP
admet-169	152	12	the	the	DET
admet-169	152	13	course	course	NOUN
admet-169	152	14	of	of	ADP
admet-169	152	15	the	the	DET
admet-169	152	16	3	3	NUM
admet-169	152	17	hour	hour	NOUN
admet-169	152	18	experiment	experiment	NOUN
admet-169	152	19	for	for	ADP
admet-169	152	20	all	all	DET
admet-169	152	21	the	the	DET
admet-169	152	22	wells	well	NOUN
admet-169	152	23	tested	test	VERB
admet-169	152	24	both	both	CCONJ
admet-169	152	25	with	with	ADP
admet-169	152	26	and	and	CCONJ
admet-169	152	27	without	without	ADP
admet-169	152	28	the	the	DET
admet-169	152	29	addition	addition	NOUN
admet-169	152	30	of	of	ADP
admet-169	152	31	the	the	DET
admet-169	152	32	drugs	drug	NOUN
admet-169	152	33	under	under	ADP
admet-169	152	34	investigation	investigation	NOUN
admet-169	152	35	(	(	PUNCT
admet-169	152	36	table	table	NOUN
admet-169	152	37	2	2	NUM
admet-169	152	38	)	)	PUNCT
admet-169	152	39	recovered	recover	VERB
admet-169	152	40	cells	cell	NOUN
admet-169	152	41	were	be	AUX
admet-169	152	42	subsequently	subsequently	ADV
admet-169	152	43	washed	wash	VERB
admet-169	152	44	during	during	ADP
admet-169	152	45	the	the	DET
admet-169	152	46	recovery	recovery	NOUN
admet-169	152	47	process	process	NOUN
admet-169	152	48	.	.	PUNCT
admet-169	153	1	table	table	NOUN
admet-169	153	2	2	2	NUM
admet-169	153	3	.	.	PUNCT
admet-169	153	4	good	good	ADJ
admet-169	153	5	monolayer	monolayer	NOUN
admet-169	153	6	integrity	integrity	NOUN
admet-169	153	7	was	be	AUX
admet-169	153	8	indicated	indicate	VERB
admet-169	153	9	by	by	ADP
admet-169	153	10	teer	teer	NOUN
admet-169	153	11	value	value	NOUN
admet-169	153	12	in	in	ADP
admet-169	153	13	the	the	DET
admet-169	153	14	range	range	NOUN
admet-169	153	15	of	of	ADP
admet-169	153	16	600	600	NUM
admet-169	153	17	–	–	SYM
admet-169	153	18	1600	1600	NUM
admet-169	153	19	ω	ω	NUM
admet-169	153	20	cm	cm	NOUN
admet-169	153	21	2	2	NUM
admet-169	153	22	.	.	PUNCT
admet-169	154	1	each	each	DET
admet-169	154	2	box	box	NOUN
admet-169	154	3	represents	represent	VERB
admet-169	154	4	one	one	NUM
admet-169	154	5	well	well	ADV
admet-169	154	6	in	in	ADP
admet-169	154	7	the	the	DET
admet-169	154	8	transwell	transwell	NOUN
admet-169	154	9	plate	plate	NOUN
admet-169	154	10	.	.	PUNCT
admet-169	155	1	the	the	DET
admet-169	155	2	grey	grey	PROPN
admet-169	155	3	boxes	box	NOUN
admet-169	155	4	indicate	indicate	VERB
admet-169	155	5	the	the	DET
admet-169	155	6	wells	well	NOUN
admet-169	155	7	without	without	ADP
admet-169	155	8	monolayer	monolayer	NOUN
admet-169	155	9	(	(	PUNCT
admet-169	155	10	blank	blank	NOUN
admet-169	155	11	)	)	PUNCT
admet-169	155	12	.	.	PUNCT
admet-169	156	1	the	the	DET
admet-169	156	2	teer	teer	NOUN
admet-169	156	3	measurements	measurement	NOUN
admet-169	156	4	were	be	AUX
admet-169	156	5	performed	perform	VERB
admet-169	156	6	before	before	ADV
admet-169	156	7	and	and	CCONJ
admet-169	156	8	after	after	ADP
admet-169	156	9	the	the	DET
admet-169	156	10	experiment	experiment	NOUN
admet-169	156	11	of	of	ADP
admet-169	156	12	transport	transport	NOUN
admet-169	156	13	studies	study	NOUN
admet-169	156	14	.	.	PUNCT
admet-169	157	1	1	1	NUM
admet-169	157	2	2	2	NUM
admet-169	157	3	3	3	NUM
admet-169	157	4	4	4	NUM
admet-169	157	5	5	5	NUM
admet-169	157	6	6	6	NUM
admet-169	157	7	a	a	DET
admet-169	157	8	1016.8	1016.8	NUM
admet-169	157	9	1674.0	1674.0	NUM
admet-169	157	10	1246.2	1246.2	NUM
admet-169	157	11	737.8	737.8	NUM
admet-169	157	12	62.0	62.0	NUM
admet-169	157	13	62.0	62.0	NUM
admet-169	157	14	b	b	PROPN
admet-169	157	15	1109.8	1109.8	NUM
admet-169	157	16	905.2	905.2	NUM
admet-169	157	17	1271.0	1271.0	NUM
admet-169	157	18	713.0	713.0	NUM
admet-169	157	19	651.0	651.0	NUM
admet-169	157	20	688.2	688.2	NUM
admet-169	157	21	c	c	NOUN
admet-169	157	22	883.5	883.5	NUM
admet-169	157	23	1153.2	1153.2	NUM
admet-169	157	24	1023.0	1023.0	NUM
admet-169	157	25	1147.0	1147.0	NUM
admet-169	157	26	744.0	744.0	NUM
admet-169	157	27	775.0	775.0	NUM
admet-169	157	28	d	d	SYM
admet-169	157	29	1240.0	1240.0	NUM
admet-169	157	30	1550.0	1550.0	NUM
admet-169	157	31	1209.0	1209.0	NUM
admet-169	157	32	1581.0	1581.0	NUM
admet-169	157	33	1612.0	1612.0	NUM
admet-169	157	34	781.2	781.2	NUM
admet-169	157	35	admet	admet	X
admet-169	157	36	&	&	CCONJ
admet-169	157	37	dmpk	dmpk	PROPN
admet-169	157	38	3(1	3(1	NUM
admet-169	157	39	)	)	PUNCT
admet-169	157	40	(	(	PUNCT
admet-169	157	41	2015	2015	NUM
admet-169	157	42	)	)	PUNCT
admet-169	157	43	51	51	NUM
admet-169	157	44	-	-	SYM
admet-169	157	45	67	67	NUM
admet-169	157	46	adaptation	adaptation	NOUN
admet-169	157	47	of	of	ADP
admet-169	157	48	human	human	ADJ
admet-169	157	49	gut	gut	NOUN
admet-169	157	50	epithelial	epithelial	ADJ
admet-169	157	51	model	model	NOUN
admet-169	157	52	doi	doi	NOUN
admet-169	157	53	:	:	PUNCT
admet-169	157	54	10.5599	10.5599	NUM
admet-169	157	55	/	/	SYM
admet-169	157	56	admet.3.1.169	admet.3.1.169	PROPN
admet-169	157	57	59	59	NUM
admet-169	157	58	referenced	reference	VERB
admet-169	157	59	literature	literature	NOUN
admet-169	157	60	recommended	recommend	VERB
admet-169	157	61	500	500	NUM
admet-169	157	62	µl	µl	NOUN
admet-169	157	63	as	as	ADP
admet-169	157	64	the	the	DET
admet-169	157	65	sampling	sample	VERB
admet-169	157	66	volume	volume	NOUN
admet-169	157	67	from	from	ADP
admet-169	157	68	the	the	DET
admet-169	157	69	receiver	receiver	ADJ
admet-169	157	70	compartment	compartment	NOUN
admet-169	157	71	,	,	PUNCT
admet-169	157	72	replacing	replace	VERB
admet-169	157	73	volume	volume	NOUN
admet-169	157	74	taken	take	VERB
admet-169	157	75	at	at	ADP
admet-169	157	76	each	each	DET
admet-169	157	77	time	time	NOUN
admet-169	157	78	point	point	NOUN
admet-169	157	79	with	with	ADP
admet-169	157	80	fresh	fresh	ADJ
admet-169	157	81	drug	drug	NOUN
admet-169	157	82	free	free	ADJ
admet-169	157	83	medium	medium	NOUN
admet-169	157	84	at	at	ADP
admet-169	157	85	the	the	DET
admet-169	157	86	correct	correct	ADJ
admet-169	157	87	temperature	temperature	NOUN
admet-169	158	1	[	[	X
admet-169	158	2	23	23	NUM
admet-169	158	3	]	]	PUNCT
admet-169	158	4	.	.	PUNCT
admet-169	159	1	in	in	ADP
admet-169	159	2	initial	initial	ADJ
admet-169	159	3	plates	plate	NOUN
admet-169	159	4	post	post	VERB
admet-169	159	5	experiment	experiment	NOUN
admet-169	159	6	teer	teer	NOUN
admet-169	159	7	values	value	NOUN
admet-169	159	8	revealed	reveal	VERB
admet-169	159	9	that	that	SCONJ
admet-169	159	10	in	in	ADP
admet-169	159	11	many	many	ADJ
admet-169	159	12	cases	case	NOUN
admet-169	159	13	monolayer	monolayer	NOUN
admet-169	159	14	integrity	integrity	NOUN
admet-169	159	15	was	be	AUX
admet-169	159	16	compromised	compromise	VERB
admet-169	159	17	with	with	ADP
admet-169	159	18	values	value	NOUN
admet-169	159	19	both	both	CCONJ
admet-169	159	20	lower	low	ADJ
admet-169	159	21	and	and	CCONJ
admet-169	159	22	higher	high	ADJ
admet-169	159	23	than	than	ADP
admet-169	159	24	specification	specification	NOUN
admet-169	159	25	.	.	PUNCT
admet-169	160	1	subsequent	subsequent	ADJ
admet-169	160	2	analysis	analysis	NOUN
admet-169	160	3	of	of	ADP
admet-169	160	4	the	the	DET
admet-169	160	5	receiver	receiver	NOUN
admet-169	160	6	compartment	compartment	NOUN
admet-169	160	7	samples	sample	NOUN
admet-169	160	8	showed	show	VERB
admet-169	160	9	abrupt	abrupt	ADJ
admet-169	160	10	changes	change	NOUN
admet-169	160	11	in	in	ADP
admet-169	160	12	mass	mass	ADJ
admet-169	160	13	transport	transport	NOUN
admet-169	160	14	,	,	PUNCT
admet-169	160	15	increasing	increase	VERB
admet-169	160	16	for	for	ADP
admet-169	160	17	teer	teer	NOUN
admet-169	160	18	values	value	NOUN
admet-169	160	19	under	under	ADP
admet-169	160	20	specification	specification	NOUN
admet-169	160	21	but	but	CCONJ
admet-169	160	22	decreasing	decrease	VERB
admet-169	160	23	for	for	ADP
admet-169	160	24	teer	teer	NOUN
admet-169	160	25	values	value	NOUN
admet-169	160	26	above	above	ADP
admet-169	160	27	specification	specification	NOUN
admet-169	160	28	.	.	PUNCT
admet-169	161	1	these	these	DET
admet-169	161	2	abrupt	abrupt	ADJ
admet-169	161	3	changes	change	NOUN
admet-169	161	4	were	be	AUX
admet-169	161	5	not	not	PART
admet-169	161	6	observed	observe	VERB
admet-169	161	7	in	in	ADP
admet-169	161	8	wells	well	NOUN
admet-169	161	9	with	with	ADP
admet-169	161	10	consistent	consistent	ADJ
admet-169	161	11	teer	teer	NOUN
admet-169	161	12	values	value	NOUN
admet-169	161	13	prior	prior	ADV
admet-169	161	14	to	to	ADP
admet-169	161	15	and	and	CCONJ
admet-169	161	16	post	post	VERB
admet-169	161	17	drug	drug	NOUN
admet-169	161	18	addition	addition	NOUN
admet-169	161	19	.	.	PUNCT
admet-169	162	1	the	the	DET
admet-169	162	2	problem	problem	NOUN
admet-169	162	3	was	be	AUX
admet-169	162	4	associated	associate	VERB
admet-169	162	5	with	with	ADP
admet-169	162	6	the	the	DET
admet-169	162	7	mixing	mixing	NOUN
admet-169	162	8	of	of	ADP
admet-169	162	9	the	the	DET
admet-169	162	10	media	medium	NOUN
admet-169	162	11	in	in	ADP
admet-169	162	12	the	the	DET
admet-169	162	13	receiver	receiver	NOUN
admet-169	162	14	compartment	compartment	NOUN
admet-169	162	15	after	after	ADP
admet-169	162	16	sampling	sample	VERB
admet-169	162	17	.	.	PUNCT
admet-169	163	1	it	it	PRON
admet-169	163	2	was	be	AUX
admet-169	163	3	concluded	conclude	VERB
admet-169	163	4	that	that	SCONJ
admet-169	163	5	hydrostatic	hydrostatic	ADJ
admet-169	163	6	pressure	pressure	NOUN
admet-169	163	7	from	from	ADP
admet-169	163	8	pipette	pipette	NOUN
admet-169	163	9	aspiration	aspiration	NOUN
admet-169	163	10	could	could	AUX
admet-169	163	11	either	either	CCONJ
admet-169	163	12	induce	induce	VERB
admet-169	163	13	stress	stress	NOUN
admet-169	163	14	on	on	ADP
admet-169	163	15	the	the	DET
admet-169	163	16	monolayer	monolayer	NOUN
admet-169	163	17	causing	cause	VERB
admet-169	163	18	a	a	DET
admet-169	163	19	break	break	NOUN
admet-169	163	20	in	in	ADP
admet-169	163	21	integrity	integrity	NOUN
admet-169	163	22	or	or	CCONJ
admet-169	163	23	introduce	introduce	VERB
admet-169	163	24	air	air	NOUN
admet-169	163	25	bubbles	bubble	NOUN
admet-169	163	26	from	from	ADP
admet-169	163	27	poor	poor	ADJ
admet-169	163	28	technique	technique	NOUN
admet-169	163	29	into	into	ADP
admet-169	163	30	the	the	DET
admet-169	163	31	pores	pore	NOUN
admet-169	163	32	of	of	ADP
admet-169	163	33	the	the	DET
admet-169	163	34	filter	filter	NOUN
admet-169	163	35	under	under	ADP
admet-169	163	36	the	the	DET
admet-169	163	37	monolayer	monolayer	NOUN
admet-169	163	38	.	.	PUNCT
admet-169	164	1	this	this	PRON
admet-169	164	2	isolated	isolate	VERB
admet-169	164	3	the	the	DET
admet-169	164	4	monolayer	monolayer	NOUN
admet-169	164	5	from	from	ADP
admet-169	164	6	the	the	DET
admet-169	164	7	receiver	receiver	ADJ
admet-169	164	8	compartment	compartment	NOUN
admet-169	164	9	,	,	PUNCT
admet-169	164	10	thereby	thereby	ADV
admet-169	164	11	decreasing	decrease	VERB
admet-169	164	12	mass	mass	NOUN
admet-169	164	13	transport	transport	NOUN
admet-169	164	14	noticeably	noticeably	ADV
admet-169	164	15	.	.	PUNCT
admet-169	165	1	a	a	DET
admet-169	165	2	broken	broken	ADJ
admet-169	165	3	monolayer	monolayer	NOUN
admet-169	165	4	exhibited	exhibit	VERB
admet-169	165	5	a	a	DET
admet-169	165	6	decrease	decrease	NOUN
admet-169	165	7	in	in	ADP
admet-169	165	8	its	its	PRON
admet-169	165	9	teer	teer	NOUN
admet-169	165	10	value	value	NOUN
admet-169	165	11	,	,	PUNCT
admet-169	165	12	but	but	CCONJ
admet-169	165	13	air	air	NOUN
admet-169	165	14	bubbles	bubble	NOUN
admet-169	165	15	increase	increase	VERB
admet-169	165	16	the	the	DET
admet-169	165	17	electrical	electrical	ADJ
admet-169	165	18	resistance	resistance	NOUN
admet-169	165	19	across	across	ADP
admet-169	165	20	the	the	DET
admet-169	165	21	monolayer	monolayer	NOUN
admet-169	165	22	artificially	artificially	ADV
admet-169	165	23	elevating	elevate	VERB
admet-169	165	24	the	the	DET
admet-169	165	25	subsequent	subsequent	ADJ
admet-169	165	26	teer	teer	NOUN
admet-169	165	27	values	value	NOUN
admet-169	165	28	.	.	PUNCT
admet-169	166	1	the	the	DET
admet-169	166	2	500	500	NUM
admet-169	166	3	µl	µl	NOUN
admet-169	166	4	of	of	ADP
admet-169	166	5	sample	sample	NOUN
admet-169	166	6	was	be	AUX
admet-169	166	7	initially	initially	ADV
admet-169	166	8	taken	take	VERB
admet-169	166	9	to	to	PART
admet-169	166	10	provide	provide	VERB
admet-169	166	11	sufficient	sufficient	ADJ
admet-169	166	12	material	material	NOUN
admet-169	166	13	for	for	ADP
admet-169	166	14	extraction	extraction	NOUN
admet-169	166	15	and	and	CCONJ
admet-169	166	16	analysis	analysis	NOUN
admet-169	166	17	of	of	ADP
admet-169	166	18	each	each	DET
admet-169	166	19	drug	drug	NOUN
admet-169	166	20	but	but	CCONJ
admet-169	166	21	caused	cause	VERB
admet-169	166	22	serious	serious	ADJ
admet-169	166	23	problems	problem	NOUN
admet-169	166	24	with	with	ADP
admet-169	166	25	the	the	DET
admet-169	166	26	monolayer	monolayer	NOUN
admet-169	166	27	.	.	PUNCT
admet-169	167	1	therefore	therefore	ADV
admet-169	167	2	,	,	PUNCT
admet-169	167	3	analytical	analytical	ADJ
admet-169	167	4	procedures	procedure	NOUN
admet-169	167	5	were	be	AUX
admet-169	167	6	developed	develop	VERB
admet-169	167	7	to	to	PART
admet-169	167	8	reduce	reduce	VERB
admet-169	167	9	the	the	DET
admet-169	167	10	amount	amount	NOUN
admet-169	167	11	of	of	ADP
admet-169	167	12	sample	sample	NOUN
admet-169	167	13	required	require	VERB
admet-169	167	14	for	for	ADP
admet-169	167	15	analysis	analysis	NOUN
admet-169	167	16	down	down	ADP
admet-169	167	17	to	to	ADP
admet-169	167	18	20	20	NUM
admet-169	167	19	µl	µl	NOUN
admet-169	167	20	while	while	SCONJ
admet-169	167	21	maintaining	maintain	VERB
admet-169	167	22	analytical	analytical	ADJ
admet-169	167	23	sensitivity	sensitivity	NOUN
admet-169	167	24	.	.	PUNCT
admet-169	168	1	hence	hence	ADV
admet-169	168	2	it	it	PRON
admet-169	168	3	became	become	VERB
admet-169	168	4	possible	possible	ADJ
admet-169	168	5	to	to	PART
admet-169	168	6	reduce	reduce	VERB
admet-169	168	7	the	the	DET
admet-169	168	8	sample	sample	NOUN
admet-169	168	9	volume	volume	NOUN
admet-169	168	10	taken	take	VERB
admet-169	168	11	on	on	ADP
admet-169	168	12	each	each	DET
admet-169	168	13	time	time	NOUN
admet-169	168	14	point	point	NOUN
admet-169	168	15	to	to	ADP
admet-169	168	16	50	50	NUM
admet-169	168	17	µl	µl	NOUN
admet-169	168	18	,	,	PUNCT
admet-169	168	19	this	this	PRON
admet-169	168	20	provided	provide	VERB
admet-169	168	21	sufficient	sufficient	ADJ
admet-169	168	22	sample	sample	NOUN
admet-169	168	23	for	for	ADP
admet-169	168	24	analysis	analysis	NOUN
admet-169	168	25	and	and	CCONJ
admet-169	168	26	additional	additional	ADJ
admet-169	168	27	volume	volume	NOUN
admet-169	168	28	for	for	ADP
admet-169	168	29	unforeseen	unforeseen	ADJ
admet-169	168	30	analytical	analytical	ADJ
admet-169	168	31	problems	problem	NOUN
admet-169	168	32	.	.	PUNCT
admet-169	169	1	the	the	DET
admet-169	169	2	reduced	reduce	VERB
admet-169	169	3	sample	sample	NOUN
admet-169	169	4	volume	volume	NOUN
admet-169	169	5	decreased	decrease	VERB
admet-169	169	6	the	the	DET
admet-169	169	7	chances	chance	NOUN
admet-169	169	8	that	that	SCONJ
admet-169	169	9	air	air	NOUN
admet-169	169	10	could	could	AUX
admet-169	169	11	get	get	VERB
admet-169	169	12	under	under	ADP
admet-169	169	13	the	the	DET
admet-169	169	14	well	well	ADV
admet-169	169	15	insert	insert	NOUN
admet-169	169	16	and	and	CCONJ
admet-169	169	17	decreased	decrease	VERB
admet-169	169	18	the	the	DET
admet-169	169	19	hydrostatic	hydrostatic	ADJ
admet-169	169	20	pressure	pressure	NOUN
admet-169	169	21	seen	see	VERB
admet-169	169	22	with	with	ADP
admet-169	169	23	the	the	DET
admet-169	169	24	50	50	NUM
admet-169	169	25	%	%	NOUN
admet-169	169	26	liquid	liquid	ADJ
admet-169	169	27	replacement	replacement	NOUN
admet-169	169	28	technique	technique	NOUN
admet-169	169	29	.	.	PUNCT
admet-169	170	1	verification	verification	NOUN
admet-169	170	2	of	of	ADP
admet-169	170	3	transport	transport	NOUN
admet-169	170	4	with	with	ADP
admet-169	170	5	gefitinib	gefitinib	NOUN
admet-169	170	6	and	and	CCONJ
admet-169	170	7	erlotinib	erlotinib	VERB
admet-169	170	8	the	the	DET
admet-169	170	9	transport	transport	NOUN
admet-169	170	10	of	of	ADP
admet-169	170	11	gefitinib	gefitinib	NOUN
admet-169	170	12	across	across	ADP
admet-169	170	13	the	the	DET
admet-169	170	14	transwell	transwell	NOUN
admet-169	170	15	system	system	NOUN
admet-169	170	16	without	without	ADP
admet-169	170	17	a	a	DET
admet-169	170	18	monolayer	monolayer	NOUN
admet-169	170	19	established	establish	VERB
admet-169	170	20	a	a	DET
admet-169	170	21	baseline	baseline	NOUN
admet-169	170	22	for	for	ADP
admet-169	170	23	passive	passive	ADJ
admet-169	170	24	diffusion	diffusion	NOUN
admet-169	170	25	across	across	ADP
admet-169	170	26	the	the	DET
admet-169	170	27	experimental	experimental	ADJ
admet-169	170	28	setup	setup	NOUN
admet-169	170	29	.	.	PUNCT
admet-169	171	1	the	the	DET
admet-169	171	2	subsequent	subsequent	ADJ
admet-169	171	3	sampling	sample	VERB
admet-169	171	4	procedure	procedure	NOUN
admet-169	171	5	dictated	dictate	VERB
admet-169	171	6	the	the	DET
admet-169	171	7	calculation	calculation	NOUN
admet-169	171	8	methodology	methodology	NOUN
admet-169	171	9	;	;	PUNCT
admet-169	171	10	each	each	DET
admet-169	171	11	15	15	NUM
admet-169	171	12	minute	minute	NOUN
admet-169	171	13	sample	sample	NOUN
admet-169	171	14	dilutes	dilute	VERB
admet-169	171	15	the	the	DET
admet-169	171	16	well	well	ADJ
admet-169	171	17	concentration	concentration	NOUN
admet-169	171	18	by	by	ADP
admet-169	171	19	a	a	DET
admet-169	171	20	factor	factor	NOUN
admet-169	171	21	of	of	ADP
admet-169	171	22	0.02	0.02	NUM
admet-169	171	23	.	.	PUNCT
admet-169	172	1	therefore	therefore	ADV
admet-169	172	2	,	,	PUNCT
admet-169	172	3	absolute	absolute	ADJ
admet-169	172	4	mass	mass	NOUN
admet-169	172	5	is	be	AUX
admet-169	172	6	determined	determine	VERB
admet-169	172	7	at	at	ADP
admet-169	172	8	each	each	DET
admet-169	172	9	time	time	NOUN
admet-169	172	10	point	point	NOUN
admet-169	172	11	,	,	PUNCT
admet-169	172	12	adjusted	adjust	VERB
admet-169	172	13	for	for	ADP
admet-169	172	14	sample	sample	NOUN
admet-169	172	15	dilution	dilution	NOUN
admet-169	172	16	and	and	CCONJ
admet-169	172	17	used	use	VERB
admet-169	172	18	as	as	ADP
admet-169	172	19	the	the	DET
admet-169	172	20	baseline	baseline	NOUN
admet-169	172	21	value	value	NOUN
admet-169	172	22	for	for	ADP
admet-169	172	23	each	each	DET
admet-169	172	24	subsequent	subsequent	ADJ
admet-169	172	25	increase	increase	NOUN
admet-169	172	26	in	in	ADP
admet-169	172	27	mass	mass	NOUN
admet-169	172	28	to	to	ADP
admet-169	172	29	the	the	DET
admet-169	172	30	next	next	ADJ
admet-169	172	31	time	time	NOUN
admet-169	172	32	point	point	NOUN
admet-169	172	33	.	.	PUNCT
admet-169	173	1	addition	addition	NOUN
admet-169	173	2	of	of	ADP
admet-169	173	3	absolute	absolute	ADJ
admet-169	173	4	mass	mass	ADJ
admet-169	173	5	transport	transport	NOUN
admet-169	173	6	for	for	ADP
admet-169	173	7	each	each	DET
admet-169	173	8	following	follow	VERB
admet-169	173	9	time	time	NOUN
admet-169	173	10	point	point	NOUN
admet-169	173	11	gave	give	VERB
admet-169	173	12	the	the	DET
admet-169	173	13	total	total	ADJ
admet-169	173	14	mass	mass	NOUN
admet-169	173	15	transported	transport	VERB
admet-169	173	16	.	.	PUNCT
admet-169	174	1	in	in	ADP
admet-169	174	2	this	this	DET
admet-169	174	3	way	way	NOUN
admet-169	174	4	absolute	absolute	ADJ
admet-169	174	5	mass	mass	NOUN
admet-169	174	6	transported	transport	VERB
admet-169	174	7	can	can	AUX
admet-169	174	8	be	be	AUX
admet-169	174	9	determined	determine	VERB
admet-169	174	10	for	for	ADP
admet-169	174	11	all	all	DET
admet-169	174	12	the	the	DET
admet-169	174	13	time	time	NOUN
admet-169	174	14	points	point	NOUN
admet-169	174	15	and	and	CCONJ
admet-169	174	16	the	the	DET
admet-169	174	17	papp	papp	NOUN
admet-169	174	18	calculated	calculate	VERB
admet-169	174	19	.	.	PUNCT
admet-169	175	1	transport	transport	NOUN
admet-169	175	2	decreased	decrease	VERB
admet-169	175	3	significantly	significantly	ADV
admet-169	175	4	when	when	SCONJ
admet-169	175	5	an	an	DET
admet-169	175	6	intact	intact	ADJ
admet-169	175	7	monolayer	monolayer	NOUN
admet-169	175	8	was	be	AUX
admet-169	175	9	used	use	VERB
admet-169	175	10	consistent	consistent	ADJ
admet-169	175	11	with	with	ADP
admet-169	175	12	expectations	expectation	NOUN
admet-169	175	13	(	(	PUNCT
admet-169	175	14	figure	figure	NOUN
admet-169	175	15	4	4	NUM
admet-169	175	16	)	)	PUNCT
admet-169	175	17	.	.	PUNCT
admet-169	176	1	this	this	PRON
admet-169	176	2	could	could	AUX
admet-169	176	3	be	be	AUX
admet-169	176	4	explained	explain	VERB
admet-169	176	5	when	when	SCONJ
admet-169	176	6	taking	take	VERB
admet-169	176	7	into	into	ADP
admet-169	176	8	account	account	NOUN
admet-169	176	9	the	the	DET
admet-169	176	10	chelation	chelation	NOUN
admet-169	176	11	complex	complex	NOUN
admet-169	176	12	being	be	AUX
admet-169	176	13	formed	form	VERB
admet-169	176	14	in	in	ADP
admet-169	176	15	both	both	CCONJ
admet-169	176	16	the	the	DET
admet-169	176	17	donor	donor	NOUN
admet-169	176	18	and	and	CCONJ
admet-169	176	19	receiver	receiver	ADJ
admet-169	176	20	compartments	compartment	NOUN
admet-169	176	21	,	,	PUNCT
admet-169	176	22	reducing	reduce	VERB
admet-169	176	23	the	the	DET
admet-169	176	24	total	total	ADJ
admet-169	176	25	drug	drug	NOUN
admet-169	176	26	being	be	AUX
admet-169	176	27	measured	measure	VERB
admet-169	176	28	by	by	ADP
admet-169	176	29	the	the	DET
admet-169	176	30	highly	highly	ADV
admet-169	176	31	specific	specific	ADJ
admet-169	176	32	lcmsms	lcmsm	NOUN
admet-169	176	33	technique	technique	NOUN
admet-169	176	34	.	.	PUNCT
admet-169	177	1	comparison	comparison	NOUN
admet-169	177	2	of	of	ADP
admet-169	177	3	the	the	DET
admet-169	177	4	accumulated	accumulate	VERB
admet-169	177	5	mass	mass	NOUN
admet-169	177	6	transport	transport	NOUN
admet-169	177	7	for	for	ADP
admet-169	177	8	gefitinib	gefitinib	NOUN
admet-169	177	9	with	with	ADP
admet-169	177	10	and	and	CCONJ
admet-169	177	11	without	without	ADP
admet-169	177	12	the	the	DET
admet-169	177	13	addition	addition	NOUN
admet-169	177	14	of	of	ADP
admet-169	177	15	bsa	bsa	PROPN
admet-169	177	16	also	also	ADV
admet-169	177	17	demonstrated	demonstrate	VERB
admet-169	177	18	a	a	DET
admet-169	177	19	clear	clear	ADJ
admet-169	177	20	trend	trend	NOUN
admet-169	177	21	(	(	PUNCT
admet-169	177	22	figure	figure	NOUN
admet-169	177	23	4	4	NUM
admet-169	177	24	)	)	PUNCT
admet-169	177	25	.	.	PUNCT
admet-169	178	1	with	with	ADP
admet-169	178	2	the	the	DET
admet-169	178	3	addition	addition	NOUN
admet-169	178	4	of	of	ADP
admet-169	178	5	bsa	bsa	PROPN
admet-169	178	6	a	a	DET
admet-169	178	7	decrease	decrease	NOUN
admet-169	178	8	in	in	ADP
admet-169	178	9	the	the	DET
admet-169	178	10	relative	relative	ADJ
admet-169	178	11	amounts	amount	NOUN
admet-169	178	12	transported	transport	VERB
admet-169	178	13	across	across	ADP
admet-169	178	14	the	the	DET
admet-169	178	15	monolayer	monolayer	NOUN
admet-169	178	16	was	be	AUX
admet-169	178	17	observed	observe	VERB
admet-169	178	18	(	(	PUNCT
admet-169	178	19	693.8	693.8	NUM
admet-169	178	20	pmol	pmol	NOUN
admet-169	178	21	vs	vs	ADP
admet-169	178	22	473.9	473.9	NUM
admet-169	178	23	pmol	pmol	NOUN
admet-169	178	24	,	,	PUNCT
admet-169	178	25	t=3	t=3	PROPN
admet-169	178	26	hr	hr	PROPN
admet-169	178	27	)	)	PUNCT
admet-169	178	28	.	.	PUNCT
admet-169	179	1	this	this	PRON
admet-169	179	2	could	could	AUX
admet-169	179	3	be	be	AUX
admet-169	179	4	explained	explain	VERB
admet-169	179	5	by	by	ADP
admet-169	179	6	the	the	DET
admet-169	179	7	high	high	ADJ
admet-169	179	8	protein	protein	NOUN
admet-169	179	9	binding	bind	VERB
admet-169	179	10	properties	property	NOUN
admet-169	179	11	of	of	ADP
admet-169	179	12	gefitinib	gefitinib	NOUN
admet-169	179	13	which	which	PRON
admet-169	179	14	would	would	AUX
admet-169	179	15	decrease	decrease	VERB
admet-169	179	16	the	the	DET
admet-169	179	17	availability	availability	NOUN
admet-169	179	18	of	of	ADP
admet-169	179	19	the	the	DET
admet-169	179	20	drug	drug	NOUN
admet-169	179	21	for	for	ADP
admet-169	179	22	transport	transport	NOUN
admet-169	179	23	across	across	ADP
admet-169	179	24	the	the	DET
admet-169	179	25	membrane	membrane	NOUN
admet-169	179	26	.	.	PUNCT
admet-169	180	1	all	all	DET
admet-169	180	2	remaining	remain	VERB
admet-169	180	3	experiments	experiment	NOUN
admet-169	180	4	were	be	AUX
admet-169	180	5	performed	perform	VERB
admet-169	180	6	with	with	ADP
admet-169	180	7	medium	medium	NOUN
admet-169	180	8	containing	contain	VERB
admet-169	180	9	5	5	NUM
admet-169	180	10	%	%	NOUN
admet-169	180	11	bsa	bsa	PROPN
admet-169	180	12	in	in	ADP
admet-169	180	13	both	both	CCONJ
admet-169	180	14	the	the	DET
admet-169	180	15	apical	apical	ADJ
admet-169	180	16	and	and	CCONJ
admet-169	180	17	basolateral	basolateral	ADJ
admet-169	180	18	compartments	compartment	NOUN
admet-169	180	19	.	.	PUNCT
admet-169	181	1	peters	peters	PROPN
admet-169	181	2	et	et	PROPN
admet-169	181	3	al	al	PROPN
admet-169	181	4	.	.	PROPN
admet-169	181	5	admet	admet	PROPN
admet-169	181	6	&	&	CCONJ
admet-169	181	7	dmpk	dmpk	PROPN
admet-169	181	8	3(1	3(1	NUM
admet-169	181	9	)	)	PUNCT
admet-169	181	10	(	(	PUNCT
admet-169	181	11	2015	2015	NUM
admet-169	181	12	)	)	PUNCT
admet-169	181	13	51	51	NUM
admet-169	181	14	-	-	SYM
admet-169	181	15	67	67	NUM
admet-169	181	16	60	60	NUM
admet-169	181	17	experiment	experiment	NOUN
admet-169	181	18	time	time	NOUN
admet-169	181	19	(	(	PUNCT
admet-169	181	20	min	min	NOUN
admet-169	181	21	)	)	PUNCT
admet-169	181	22	t	t	NOUN
admet-169	181	23	o	o	X
admet-169	181	24	ta	ta	ADP
admet-169	181	25	l	l	PROPN
admet-169	181	26	m	m	VERB
admet-169	181	27	a	a	DET
admet-169	181	28	s	s	X
admet-169	181	29	s	s	X
admet-169	181	30	(	(	PUNCT
admet-169	181	31	p	p	NOUN
admet-169	181	32	m	m	PROPN
admet-169	181	33	o	o	NOUN
admet-169	181	34	l	l	NOUN
admet-169	181	35	)	)	PUNCT
admet-169	181	36	t	t	PROPN
admet-169	181	37	ra	ra	PROPN
admet-169	182	1	n	n	PROPN
admet-169	182	2	s	s	PROPN
admet-169	182	3	p	p	NOUN
admet-169	182	4	o	o	X
admet-169	182	5	rt	rt	X
admet-169	182	6	e	e	PROPN
admet-169	182	7	d	d	PROPN
admet-169	182	8	0	0	NUM
admet-169	182	9	50	50	NUM
admet-169	182	10	100	100	NUM
admet-169	182	11	150	150	NUM
admet-169	182	12	200	200	NUM
admet-169	182	13	0	0	NUM
admet-169	182	14	500	500	NUM
admet-169	182	15	1000	1000	NUM
admet-169	182	16	1500	1500	NUM
admet-169	182	17	2000	2000	NUM
admet-169	182	18	without	without	ADP
admet-169	182	19	monolayer	monolayer	NOUN
admet-169	182	20	with	with	ADP
admet-169	182	21	monolayer	monolayer	NOUN
admet-169	182	22	with	with	ADP
admet-169	182	23	monolayer	monolayer	NOUN
admet-169	182	24	+	+	CCONJ
admet-169	182	25	5	5	NUM
admet-169	182	26	%	%	NOUN
admet-169	182	27	bsa	bsa	NOUN
admet-169	182	28	figure	figure	VERB
admet-169	182	29	4	4	NUM
admet-169	182	30	.	.	PUNCT
admet-169	182	31	graphical	graphical	ADJ
admet-169	182	32	representation	representation	NOUN
admet-169	182	33	of	of	ADP
admet-169	182	34	transport	transport	NOUN
admet-169	182	35	characteristics	characteristic	NOUN
admet-169	182	36	of	of	ADP
admet-169	182	37	gefitinib	gefitinib	NOUN
admet-169	182	38	(	(	PUNCT
admet-169	182	39	n=4	n=4	NOUN
admet-169	182	40	)	)	PUNCT
admet-169	182	41	with	with	ADP
admet-169	182	42	and	and	CCONJ
admet-169	182	43	without	without	ADP
admet-169	182	44	a	a	DET
admet-169	182	45	monolayer	monolayer	NOUN
admet-169	182	46	across	across	ADP
admet-169	182	47	the	the	DET
admet-169	182	48	transwell	transwell	NOUN
admet-169	182	49	setup	setup	NOUN
admet-169	182	50	.	.	PUNCT
admet-169	183	1	where	where	SCONJ
admet-169	183	2	the	the	DET
admet-169	183	3	medium	medium	ADJ
admet-169	183	4	(	(	PUNCT
admet-169	183	5	hbss	hbss	NOUN
admet-169	183	6	buffer	buffer	NOUN
admet-169	183	7	)	)	PUNCT
admet-169	183	8	did	do	AUX
admet-169	183	9	not	not	PART
admet-169	183	10	include	include	VERB
admet-169	183	11	bsa	bsa	PROPN
admet-169	183	12	the	the	DET
admet-169	183	13	total	total	ADJ
admet-169	183	14	mass	mass	NOUN
admet-169	183	15	transported	transport	VERB
admet-169	183	16	would	would	AUX
admet-169	183	17	have	have	AUX
admet-169	183	18	been	be	AUX
admet-169	183	19	affected	affect	VERB
admet-169	183	20	by	by	ADP
admet-169	183	21	chelation	chelation	NOUN
admet-169	183	22	of	of	ADP
admet-169	183	23	gefitinib	gefitinib	NOUN
admet-169	183	24	with	with	ADP
admet-169	183	25	either	either	CCONJ
admet-169	183	26	calcium	calcium	NOUN
admet-169	183	27	or	or	CCONJ
admet-169	183	28	magnesium	magnesium	NOUN
admet-169	183	29	reducing	reduce	VERB
admet-169	183	30	the	the	DET
admet-169	183	31	measurable	measurable	ADJ
admet-169	183	32	drug	drug	NOUN
admet-169	183	33	concentrations	concentration	NOUN
admet-169	183	34	significantly	significantly	ADV
admet-169	183	35	.	.	PUNCT
admet-169	184	1	addition	addition	NOUN
admet-169	184	2	of	of	ADP
admet-169	184	3	a	a	DET
admet-169	184	4	monolayer	monolayer	NOUN
admet-169	184	5	to	to	ADP
admet-169	184	6	the	the	DET
admet-169	184	7	system	system	NOUN
admet-169	184	8	slows	slow	VERB
admet-169	184	9	transport	transport	NOUN
admet-169	184	10	hence	hence	ADV
admet-169	184	11	total	total	ADJ
admet-169	184	12	accumulated	accumulate	VERB
admet-169	184	13	mass	mass	NOUN
admet-169	184	14	while	while	SCONJ
admet-169	184	15	further	further	ADJ
admet-169	184	16	addition	addition	NOUN
admet-169	184	17	of	of	ADP
admet-169	184	18	5	5	NUM
admet-169	184	19	%	%	NOUN
admet-169	184	20	bsa	bsa	PROPN
admet-169	184	21	also	also	ADV
admet-169	184	22	would	would	AUX
admet-169	184	23	slow	slow	VERB
admet-169	184	24	transport	transport	NOUN
admet-169	184	25	lowering	lower	VERB
admet-169	184	26	the	the	DET
admet-169	184	27	total	total	ADJ
admet-169	184	28	accumulated	accumulate	VERB
admet-169	184	29	mass	mass	NOUN
admet-169	184	30	as	as	ADV
admet-169	184	31	well	well	ADV
admet-169	184	32	.	.	PUNCT
admet-169	185	1	model	model	ADJ
admet-169	185	2	pharmacokinetic	pharmacokinetic	ADJ
admet-169	185	3	absorption	absorption	NOUN
admet-169	185	4	apical	apical	ADJ
admet-169	185	5	to	to	ADP
admet-169	185	6	basolateral	basolateral	NOUN
admet-169	185	7	(	(	PUNCT
admet-169	185	8	a	a	DET
admet-169	185	9	b	b	NOUN
admet-169	185	10	)	)	PUNCT
admet-169	185	11	accumulative	accumulative	ADJ
admet-169	185	12	mass	mass	NOUN
admet-169	185	13	transport	transport	NOUN
admet-169	185	14	of	of	ADP
admet-169	185	15	gefitinib	gefitinib	NOUN
admet-169	185	16	in	in	ADP
admet-169	185	17	the	the	DET
admet-169	185	18	apical	apical	ADJ
admet-169	185	19	to	to	ADP
admet-169	185	20	basolateral	basolateral	ADJ
admet-169	185	21	direction	direction	NOUN
admet-169	185	22	(	(	PUNCT
admet-169	185	23	figure	figure	NOUN
admet-169	185	24	5	5	NUM
admet-169	185	25	)	)	PUNCT
admet-169	185	26	showed	show	VERB
admet-169	185	27	a	a	DET
admet-169	185	28	clear	clear	ADJ
admet-169	185	29	linear	linear	ADJ
admet-169	185	30	increase	increase	NOUN
admet-169	185	31	over	over	ADP
admet-169	185	32	the	the	DET
admet-169	185	33	time	time	NOUN
admet-169	185	34	period	period	NOUN
admet-169	185	35	measured	measure	VERB
admet-169	185	36	(	(	PUNCT
admet-169	185	37	papp	papp	NOUN
admet-169	185	38	of	of	ADP
admet-169	185	39	0.38	0.38	NUM
admet-169	185	40	±	±	NUM
admet-169	185	41	0.05	0.05	NUM
admet-169	185	42	µm/	µm/	X
admet-169	185	43	s	s	NOUN
admet-169	185	44	)	)	PUNCT
admet-169	185	45	.	.	PUNCT
admet-169	186	1	when	when	SCONJ
admet-169	186	2	sodium	sodium	NOUN
admet-169	186	3	azide	azide	NOUN
admet-169	186	4	(	(	PUNCT
admet-169	186	5	nan3	nan3	PROPN
admet-169	186	6	)	)	PUNCT
admet-169	186	7	was	be	AUX
admet-169	186	8	added	add	VERB
admet-169	186	9	to	to	ADP
admet-169	186	10	the	the	DET
admet-169	186	11	system	system	NOUN
admet-169	186	12	all	all	DET
admet-169	186	13	atp	atp	PROPN
admet-169	186	14	dependent	dependent	ADJ
admet-169	186	15	transport	transport	NOUN
admet-169	186	16	processes	process	NOUN
admet-169	186	17	would	would	AUX
admet-169	186	18	have	have	AUX
admet-169	186	19	been	be	AUX
admet-169	186	20	blocked	block	VERB
admet-169	186	21	.	.	PUNCT
admet-169	187	1	in	in	ADP
admet-169	187	2	this	this	DET
admet-169	187	3	situation	situation	NOUN
admet-169	187	4	gefitinib	gefitinib	NOUN
admet-169	187	5	showed	show	VERB
admet-169	187	6	decrease	decrease	NOUN
admet-169	187	7	in	in	ADP
admet-169	187	8	the	the	DET
admet-169	187	9	observed	observe	VERB
admet-169	187	10	mass	mass	NOUN
admet-169	187	11	transported	transport	VERB
admet-169	187	12	(	(	PUNCT
admet-169	187	13	papp	papp	NOUN
admet-169	187	14	of	of	ADP
admet-169	187	15	0.32	0.32	NUM
admet-169	187	16	±	±	NUM
admet-169	187	17	0.018	0.018	NUM
admet-169	187	18	µm	µm	ADP
admet-169	187	19	/	/	SYM
admet-169	187	20	s	s	NOUN
admet-169	187	21	)	)	PUNCT
admet-169	187	22	while	while	SCONJ
admet-169	187	23	an	an	DET
admet-169	187	24	even	even	ADV
admet-169	187	25	greater	great	ADJ
admet-169	187	26	decrease	decrease	NOUN
admet-169	187	27	was	be	AUX
admet-169	187	28	observed	observe	VERB
admet-169	187	29	when	when	SCONJ
admet-169	187	30	using	use	VERB
admet-169	187	31	the	the	DET
admet-169	187	32	specific	specific	ADJ
admet-169	187	33	abg2	abg2	PROPN
admet-169	187	34	blocker	blocker	NOUN
admet-169	187	35	ko143	ko143	PROPN
admet-169	187	36	(	(	PUNCT
admet-169	187	37	papp	papp	NOUN
admet-169	187	38	of	of	ADP
admet-169	187	39	0.26	0.26	NUM
admet-169	187	40	±	±	NUM
admet-169	187	41	0.013	0.013	NUM
admet-169	187	42	)	)	PUNCT
admet-169	187	43	.	.	PUNCT
admet-169	188	1	passive	passive	ADJ
admet-169	188	2	transport	transport	NOUN
admet-169	188	3	mechanisms	mechanism	NOUN
admet-169	188	4	would	would	AUX
admet-169	188	5	not	not	PART
admet-169	188	6	be	be	AUX
admet-169	188	7	affected	affect	VERB
admet-169	188	8	by	by	ADP
admet-169	188	9	nan3	nan3	PROPN
admet-169	188	10	but	but	CCONJ
admet-169	188	11	all	all	DET
admet-169	188	12	active	active	ADJ
admet-169	188	13	mechanisms	mechanism	NOUN
admet-169	188	14	would	would	AUX
admet-169	188	15	,	,	PUNCT
admet-169	188	16	similarly	similarly	ADV
admet-169	188	17	ko143	ko143	PROPN
admet-169	188	18	would	would	AUX
admet-169	188	19	not	not	PART
admet-169	188	20	inhibit	inhibit	VERB
admet-169	188	21	passive	passive	ADJ
admet-169	188	22	diffusion	diffusion	NOUN
admet-169	188	23	but	but	CCONJ
admet-169	188	24	all	all	DET
admet-169	188	25	mechanisms	mechanism	NOUN
admet-169	188	26	involving	involve	VERB
admet-169	188	27	the	the	DET
admet-169	188	28	abcg2	abcg2	NOUN
admet-169	188	29	transporter	transporter	NOUN
admet-169	188	30	would	would	AUX
admet-169	188	31	be	be	AUX
admet-169	188	32	inhibited	inhibit	VERB
admet-169	188	33	.	.	PUNCT
admet-169	189	1	therefore	therefore	ADV
admet-169	189	2	it	it	PRON
admet-169	189	3	can	can	AUX
admet-169	189	4	be	be	AUX
admet-169	189	5	concluded	conclude	VERB
admet-169	189	6	from	from	ADP
admet-169	189	7	this	this	DET
admet-169	189	8	evidence	evidence	NOUN
admet-169	189	9	that	that	SCONJ
admet-169	189	10	gefitinib	gefitinib	NOUN
admet-169	189	11	demonstrated	demonstrate	VERB
admet-169	189	12	evidence	evidence	NOUN
admet-169	189	13	of	of	ADP
admet-169	189	14	a	a	DET
admet-169	189	15	partial	partial	ADJ
admet-169	189	16	role	role	NOUN
admet-169	189	17	for	for	ADP
admet-169	189	18	active	active	ADJ
admet-169	189	19	transport	transport	NOUN
admet-169	189	20	mechanisms	mechanism	NOUN
admet-169	189	21	that	that	PRON
admet-169	189	22	occur	occur	VERB
admet-169	189	23	alongside	alongside	ADP
admet-169	189	24	more	more	ADV
admet-169	189	25	passive	passive	ADJ
admet-169	189	26	mechanisms	mechanism	NOUN
admet-169	189	27	.	.	PUNCT
admet-169	190	1	admet	admet	PROPN
admet-169	190	2	&	&	CCONJ
admet-169	190	3	dmpk	dmpk	PROPN
admet-169	190	4	3(1	3(1	NUM
admet-169	190	5	)	)	PUNCT
admet-169	190	6	(	(	PUNCT
admet-169	190	7	2015	2015	NUM
admet-169	190	8	)	)	PUNCT
admet-169	190	9	51	51	NUM
admet-169	190	10	-	-	SYM
admet-169	190	11	67	67	NUM
admet-169	190	12	adaptation	adaptation	NOUN
admet-169	190	13	of	of	ADP
admet-169	190	14	human	human	ADJ
admet-169	190	15	gut	gut	NOUN
admet-169	190	16	epithelial	epithelial	ADJ
admet-169	190	17	model	model	NOUN
admet-169	190	18	doi	doi	NOUN
admet-169	190	19	:	:	PUNCT
admet-169	190	20	10.5599	10.5599	NUM
admet-169	190	21	/	/	SYM
admet-169	190	22	admet.3.1.169	admet.3.1.169	PROPN
admet-169	190	23	61	61	NUM
admet-169	190	24	0	0	NUM
admet-169	190	25	50	50	NUM
admet-169	190	26	100	100	NUM
admet-169	190	27	150	150	NUM
admet-169	190	28	200	200	NUM
admet-169	190	29	0	0	NUM
admet-169	190	30	200	200	NUM
admet-169	190	31	400	400	NUM
admet-169	190	32	600	600	NUM
admet-169	190	33	800	800	NUM
admet-169	190	34	apical	apical	ADJ
admet-169	190	35	to	to	ADP
admet-169	190	36	basolateral	basolateral	ADJ
admet-169	190	37	apical	apical	ADJ
admet-169	190	38	to	to	ADP
admet-169	190	39	basolateral	basolateral	ADJ
admet-169	190	40	+	+	CCONJ
admet-169	190	41	ko143	ko143	ADJ
admet-169	190	42	apical	apical	ADJ
admet-169	190	43	to	to	ADP
admet-169	190	44	basolateral	basolateral	NOUN
admet-169	190	45	+	+	CCONJ
admet-169	190	46	nan	nan	PROPN
admet-169	190	47	3	3	NUM
admet-169	190	48	t	t	NOUN
admet-169	190	49	o	o	X
admet-169	190	50	ta	ta	ADP
admet-169	190	51	l	l	PROPN
admet-169	190	52	m	m	VERB
admet-169	190	53	a	a	DET
admet-169	190	54	s	s	X
admet-169	190	55	s	s	X
admet-169	190	56	(	(	PUNCT
admet-169	190	57	p	p	NOUN
admet-169	190	58	m	m	PROPN
admet-169	190	59	o	o	NOUN
admet-169	190	60	l	l	NOUN
admet-169	190	61	)	)	PUNCT
admet-169	190	62	t	t	PROPN
admet-169	190	63	ra	ra	PROPN
admet-169	191	1	n	n	PROPN
admet-169	191	2	s	s	PROPN
admet-169	191	3	p	p	NOUN
admet-169	191	4	o	o	X
admet-169	191	5	rt	rt	PROPN
admet-169	191	6	e	e	PROPN
admet-169	191	7	d	d	PROPN
admet-169	191	8	time	time	NOUN
admet-169	191	9	(	(	PUNCT
admet-169	191	10	minutes	minute	NOUN
admet-169	191	11	)	)	PUNCT
admet-169	191	12	0	0	NUM
admet-169	191	13	50	50	NUM
admet-169	191	14	100	100	NUM
admet-169	191	15	150	150	NUM
admet-169	191	16	200	200	NUM
admet-169	191	17	0	0	NUM
admet-169	191	18	200	200	NUM
admet-169	191	19	400	400	NUM
admet-169	191	20	600	600	NUM
admet-169	191	21	800	800	NUM
admet-169	191	22	basolateral	basolateral	NOUN
admet-169	191	23	to	to	ADP
admet-169	191	24	apical	apical	ADJ
admet-169	191	25	+	+	CCONJ
admet-169	191	26	nan3	nan3	NOUN
admet-169	191	27	basolateral	basolateral	NOUN
admet-169	191	28	to	to	ADP
admet-169	191	29	apical	apical	ADJ
admet-169	191	30	+	+	CCONJ
admet-169	191	31	ko143	ko143	PROPN
admet-169	191	32	basolateral	basolateral	NOUN
admet-169	191	33	to	to	ADP
admet-169	191	34	apical	apical	ADJ
admet-169	191	35	figure	figure	NOUN
admet-169	191	36	5	5	NUM
admet-169	191	37	.	.	PUNCT
admet-169	191	38	graphical	graphical	ADJ
admet-169	191	39	representation	representation	NOUN
admet-169	191	40	of	of	ADP
admet-169	191	41	accumulated	accumulate	VERB
admet-169	191	42	drug	drug	NOUN
admet-169	191	43	transport	transport	NOUN
admet-169	191	44	in	in	ADP
admet-169	191	45	the	the	DET
admet-169	191	46	apical	apical	ADJ
admet-169	191	47	to	to	ADP
admet-169	191	48	basolateral	basolateral	NOUN
admet-169	191	49	(	(	PUNCT
admet-169	191	50	a	a	NOUN
admet-169	191	51	)	)	PUNCT
admet-169	191	52	and	and	CCONJ
admet-169	191	53	the	the	DET
admet-169	191	54	basolateral	basolateral	NOUN
admet-169	191	55	to	to	ADP
admet-169	191	56	apical	apical	ADJ
admet-169	191	57	(	(	PUNCT
admet-169	191	58	b	b	NOUN
admet-169	191	59	)	)	PUNCT
admet-169	191	60	directions	direction	NOUN
admet-169	191	61	for	for	ADP
admet-169	191	62	gefitinib	gefitinib	NOUN
admet-169	191	63	using	use	VERB
admet-169	191	64	hbss	hbss	NOUN
admet-169	191	65	medium	medium	NOUN
admet-169	191	66	containing	contain	VERB
admet-169	191	67	5	5	NUM
admet-169	191	68	%	%	NOUN
admet-169	191	69	bsa	bsa	PROPN
admet-169	191	70	.	.	PROPN
admet-169	191	71	interference	interference	NOUN
admet-169	191	72	in	in	ADP
admet-169	191	73	total	total	ADJ
admet-169	191	74	accumulated	accumulate	VERB
admet-169	191	75	transport	transport	NOUN
admet-169	191	76	is	be	AUX
admet-169	191	77	demonstrated	demonstrate	VERB
admet-169	191	78	using	use	VERB
admet-169	191	79	ko143	ko143	PROPN
admet-169	191	80	(	(	PUNCT
admet-169	191	81	abcg2	abcg2	NOUN
admet-169	191	82	inhibitor	inhibitor	NOUN
admet-169	191	83	)	)	PUNCT
admet-169	191	84	and	and	CCONJ
admet-169	191	85	nan3	nan3	PROPN
admet-169	191	86	(	(	PUNCT
admet-169	191	87	inhibitor	inhibitor	NOUN
admet-169	191	88	of	of	ADP
admet-169	191	89	atp	atp	PROPN
admet-169	191	90	processes	process	NOUN
admet-169	191	91	)	)	PUNCT
admet-169	191	92	.	.	PUNCT
admet-169	192	1	erlotinib	erlotinib	NOUN
admet-169	192	2	(	(	PUNCT
admet-169	192	3	figure	figure	NOUN
admet-169	192	4	6	6	NUM
admet-169	192	5	)	)	PUNCT
admet-169	192	6	demonstrated	demonstrate	VERB
admet-169	192	7	a	a	DET
admet-169	192	8	similar	similar	ADJ
admet-169	192	9	linear	linear	ADJ
admet-169	192	10	increase	increase	NOUN
admet-169	192	11	over	over	ADP
admet-169	192	12	the	the	DET
admet-169	192	13	time	time	NOUN
admet-169	192	14	period	period	NOUN
admet-169	192	15	to	to	ADP
admet-169	192	16	gefitinib	gefitinib	NOUN
admet-169	192	17	but	but	CCONJ
admet-169	192	18	at	at	ADP
admet-169	192	19	4	4	NUM
admet-169	192	20	4.5	4.5	NUM
admet-169	192	21	fold	fold	ADJ
admet-169	192	22	higher	high	ADJ
admet-169	192	23	concentrations	concentration	NOUN
admet-169	192	24	(	(	PUNCT
admet-169	192	25	papp	papp	NOUN
admet-169	192	26	of	of	ADP
admet-169	192	27	1.72	1.72	NUM
admet-169	192	28	±	±	NUM
admet-169	192	29	0.08	0.08	NUM
admet-169	192	30	µm/	µm/	X
admet-169	192	31	s	s	NOUN
admet-169	192	32	)	)	PUNCT
admet-169	192	33	.	.	PUNCT
admet-169	193	1	with	with	ADP
admet-169	193	2	the	the	DET
admet-169	193	3	addition	addition	NOUN
admet-169	193	4	of	of	ADP
admet-169	193	5	nan3	nan3	PROPN
admet-169	193	6	erlotinib	erlotinib	PROPN
admet-169	193	7	had	have	VERB
admet-169	193	8	an	an	DET
admet-169	193	9	increase	increase	NOUN
admet-169	193	10	in	in	ADP
admet-169	193	11	mass	mass	NOUN
admet-169	193	12	transported	transport	VERB
admet-169	193	13	(	(	PUNCT
admet-169	193	14	papp	papp	NOUN
admet-169	193	15	of	of	ADP
admet-169	193	16	2.06	2.06	NUM
admet-169	193	17	±	±	NUM
admet-169	193	18	0.15	0.15	NUM
admet-169	193	19	µm/	µm/	X
admet-169	193	20	s	s	PART
admet-169	193	21	)	)	PUNCT
admet-169	193	22	,	,	PUNCT
admet-169	193	23	however	however	ADV
admet-169	193	24	,	,	PUNCT
admet-169	193	25	this	this	PRON
admet-169	193	26	was	be	AUX
admet-169	193	27	not	not	PART
admet-169	193	28	significantly	significantly	ADV
admet-169	193	29	different	different	ADJ
admet-169	193	30	to	to	ADP
admet-169	193	31	the	the	DET
admet-169	193	32	transport	transport	NOUN
admet-169	193	33	flow	flow	NOUN
admet-169	193	34	without	without	ADP
admet-169	193	35	nan3	nan3	PROPN
admet-169	193	36	.	.	PUNCT
admet-169	194	1	the	the	DET
admet-169	194	2	limited	limited	ADJ
admet-169	194	3	effect	effect	NOUN
admet-169	194	4	of	of	ADP
admet-169	194	5	nan3	nan3	PROPN
admet-169	194	6	on	on	ADP
admet-169	194	7	the	the	DET
admet-169	194	8	transport	transport	NOUN
admet-169	194	9	of	of	ADP
admet-169	194	10	erlotinib	erlotinib	NOUN
admet-169	194	11	across	across	ADP
admet-169	194	12	the	the	DET
admet-169	194	13	membrane	membrane	NOUN
admet-169	194	14	suggested	suggest	VERB
admet-169	194	15	that	that	SCONJ
admet-169	194	16	erlotinib	erlotinib	NOUN
admet-169	194	17	transport	transport	NOUN
admet-169	194	18	is	be	AUX
admet-169	194	19	predominantly	predominantly	ADV
admet-169	194	20	a	a	DET
admet-169	194	21	passive	passive	ADJ
admet-169	194	22	system	system	NOUN
admet-169	194	23	.	.	PUNCT
admet-169	195	1	however	however	ADV
admet-169	195	2	,	,	PUNCT
admet-169	195	3	with	with	ADP
admet-169	195	4	the	the	DET
admet-169	195	5	addition	addition	NOUN
admet-169	195	6	of	of	ADP
admet-169	195	7	ko143	ko143	PROPN
admet-169	195	8	a	a	DET
admet-169	195	9	decrease	decrease	NOUN
admet-169	195	10	in	in	ADP
admet-169	195	11	mass	mass	ADJ
admet-169	195	12	transported	transport	VERB
admet-169	195	13	was	be	AUX
admet-169	195	14	observed	observe	VERB
admet-169	195	15	that	that	PRON
admet-169	195	16	was	be	AUX
admet-169	195	17	significantly	significantly	ADV
admet-169	195	18	different	different	ADJ
admet-169	195	19	to	to	ADP
admet-169	195	20	the	the	DET
admet-169	195	21	control	control	NOUN
admet-169	195	22	condition	condition	NOUN
admet-169	195	23	(	(	PUNCT
admet-169	195	24	papp	papp	NOUN
admet-169	195	25	of	of	ADP
admet-169	195	26	1.23	1.23	NUM
admet-169	195	27	±	±	NUM
admet-169	195	28	0.06	0.06	NUM
admet-169	195	29	,	,	PUNCT
admet-169	195	30	p	p	X
admet-169	195	31	>	>	X
admet-169	195	32	0.05	0.05	NUM
admet-169	195	33	)	)	PUNCT
admet-169	195	34	.	.	PUNCT
admet-169	196	1	this	this	PRON
admet-169	196	2	suggested	suggest	VERB
admet-169	196	3	that	that	SCONJ
admet-169	196	4	an	an	DET
admet-169	196	5	active	active	ADJ
admet-169	196	6	mechanism	mechanism	NOUN
admet-169	196	7	was	be	AUX
admet-169	196	8	involved	involve	VERB
admet-169	196	9	but	but	CCONJ
admet-169	196	10	was	be	AUX
admet-169	196	11	an	an	DET
admet-169	196	12	elimination	elimination	NOUN
admet-169	196	13	mechanism	mechanism	NOUN
admet-169	196	14	on	on	ADP
admet-169	196	15	the	the	DET
admet-169	196	16	apical	apical	ADJ
admet-169	196	17	membrane	membrane	NOUN
admet-169	196	18	only	only	ADV
admet-169	196	19	.	.	PUNCT
admet-169	197	1	table	table	NOUN
admet-169	197	2	3	3	NUM
admet-169	197	3	.	.	PUNCT
admet-169	198	1	summary	summary	NOUN
admet-169	198	2	of	of	ADP
admet-169	198	3	the	the	DET
admet-169	198	4	papp	papp	NOUN
admet-169	198	5	values	value	NOUN
admet-169	198	6	in	in	ADP
admet-169	198	7	both	both	CCONJ
admet-169	198	8	a	a	DET
admet-169	198	9	-	-	PUNCT
admet-169	198	10	b	b	NOUN
admet-169	198	11	and	and	CCONJ
admet-169	198	12	b	b	NOUN
admet-169	198	13	-	-	PUNCT
admet-169	198	14	a	a	PRON
admet-169	198	15	directions	direction	NOUN
admet-169	198	16	for	for	ADP
admet-169	198	17	erlotinib	erlotinib	NOUN
admet-169	198	18	and	and	CCONJ
admet-169	198	19	gefitinib	gefitinib	NOUN
admet-169	198	20	,	,	PUNCT
admet-169	198	21	with	with	ADP
admet-169	198	22	and	and	CCONJ
admet-169	198	23	without	without	ADP
admet-169	198	24	the	the	DET
admet-169	198	25	inclusion	inclusion	NOUN
admet-169	198	26	of	of	ADP
admet-169	198	27	the	the	DET
admet-169	198	28	inhibitors	inhibitor	NOUN
admet-169	198	29	ko143	ko143	NOUN
admet-169	198	30	and	and	CCONJ
admet-169	198	31	nan3.statistical	nan3.statistical	PROPN
admet-169	198	32	comparisons	comparison	NOUN
admet-169	198	33	were	be	AUX
admet-169	198	34	made	make	VERB
admet-169	198	35	using	use	VERB
admet-169	198	36	paired	pair	VERB
admet-169	198	37	students	student	NOUN
admet-169	198	38	t	t	NOUN
admet-169	198	39	-	-	PUNCT
admet-169	198	40	test	test	NOUN
admet-169	198	41	(	(	PUNCT
admet-169	198	42	#	#	NOUN
admet-169	198	43	)	)	PUNCT
admet-169	198	44	comparing	compare	VERB
admet-169	198	45	the	the	DET
admet-169	198	46	papp	papp	NOUN
admet-169	198	47	a	a	PROPN
admet-169	198	48	-	-	PUNCT
admet-169	198	49	b	b	NOUN
admet-169	198	50	to	to	ADP
admet-169	198	51	the	the	DET
admet-169	198	52	papp	papp	NOUN
admet-169	198	53	b	b	PROPN
admet-169	198	54	-	-	PUNCT
admet-169	198	55	a.	a.	NOUN
admet-169	198	56	additional	additional	ADJ
admet-169	198	57	comparisons	comparison	NOUN
admet-169	198	58	were	be	AUX
admet-169	198	59	made	make	VERB
admet-169	198	60	(	(	PUNCT
admet-169	198	61	*	*	NOUN
admet-169	198	62	)	)	PUNCT
admet-169	198	63	between	between	ADP
admet-169	198	64	the	the	DET
admet-169	198	65	control	control	NOUN
admet-169	198	66	and	and	CCONJ
admet-169	198	67	either	either	CCONJ
admet-169	198	68	the	the	DET
admet-169	198	69	addition	addition	NOUN
admet-169	198	70	of	of	ADP
admet-169	198	71	ko143	ko143	PROPN
admet-169	198	72	or	or	CCONJ
admet-169	198	73	nan3	nan3	NOUN
admet-169	198	74	gefitinib	gefitinib	NOUN
admet-169	198	75	(	(	PUNCT
admet-169	198	76	n=9	n=9	NOUN
admet-169	198	77	)	)	PUNCT
admet-169	198	78	papp	papp	NOUN
admet-169	198	79	(	(	PUNCT
admet-169	198	80	a	a	PROPN
admet-169	198	81	-	-	PUNCT
admet-169	198	82	b	b	NOUN
admet-169	198	83	)	)	PUNCT
admet-169	198	84	papp	papp	NOUN
admet-169	198	85	(	(	PUNCT
admet-169	198	86	b	b	NOUN
admet-169	198	87	-	-	PUNCT
admet-169	198	88	a	a	PRON
admet-169	198	89	)	)	PUNCT
admet-169	198	90	efflux	efflux	NOUN
admet-169	198	91	ratio	ratio	NOUN
admet-169	198	92	control	control	NOUN
admet-169	198	93	0.38	0.38	NUM
admet-169	198	94	±	±	NUM
admet-169	198	95	0.05	0.05	NUM
admet-169	198	96	µm	µm	NOUN
admet-169	198	97	/	/	SYM
admet-169	198	98	s	s	PART
admet-169	198	99	0.39	0.39	NUM
admet-169	198	100	±	±	NUM
admet-169	198	101	0.038	0.038	NUM
admet-169	198	102	µm	µm	NOUN
admet-169	198	103	/	/	SYM
admet-169	198	104	s	s	PART
admet-169	198	105	1.03	1.03	NUM
admet-169	198	106	#	#	NOUN
admet-169	198	107	+	+	PROPN
admet-169	198	108	ko143	ko143	PROPN
admet-169	198	109	0.26	0.26	NUM
admet-169	198	110	±	±	NUM
admet-169	198	111	0.013	0.013	NUM
admet-169	198	112	µm	µm	NOUN
admet-169	198	113	/	/	SYM
admet-169	198	114	s	s	PROPN
admet-169	198	115	*	*	NOUN
admet-169	198	116	*	*	PROPN
admet-169	198	117	0.26	0.26	NUM
admet-169	198	118	±	±	NUM
admet-169	198	119	0.012	0.012	NUM
admet-169	198	120	µm	µm	NOUN
admet-169	198	121	/	/	SYM
admet-169	198	122	s	s	PROPN
admet-169	198	123	*	*	NOUN
admet-169	198	124	*	*	PROPN
admet-169	198	125	1.00	1.00	NUM
admet-169	198	126	#	#	NOUN
admet-169	198	127	+	+	NOUN
admet-169	198	128	nan3	nan3	PROPN
admet-169	198	129	0.32	0.32	NUM
admet-169	198	130	±	±	NUM
admet-169	198	131	0.018	0.018	NUM
admet-169	198	132	µm	µm	ADP
admet-169	198	133	/	/	SYM
admet-169	198	134	s	s	PROPN
admet-169	198	135	*	*	PROPN
admet-169	198	136	0.57	0.57	NUM
admet-169	198	137	±	±	NUM
admet-169	198	138	0.14	0.14	NUM
admet-169	198	139	µm	µm	NOUN
admet-169	198	140	/	/	SYM
admet-169	198	141	s	s	PROPN
admet-169	198	142	*	*	NOUN
admet-169	198	143	*	*	PROPN
admet-169	199	1	1.78	1.78	NUM
admet-169	199	2	#	#	NOUN
admet-169	199	3	#	#	NOUN
admet-169	199	4	erlotinib	erlotinib	NOUN
admet-169	199	5	(	(	PUNCT
admet-169	199	6	n=12	n=12	NOUN
admet-169	199	7	)	)	PUNCT
admet-169	199	8	papp	papp	NOUN
admet-169	199	9	(	(	PUNCT
admet-169	199	10	a	a	PROPN
admet-169	199	11	-	-	PUNCT
admet-169	199	12	b	b	NOUN
admet-169	199	13	)	)	PUNCT
admet-169	199	14	papp	papp	NOUN
admet-169	199	15	(	(	PUNCT
admet-169	199	16	b	b	NOUN
admet-169	199	17	-	-	PUNCT
admet-169	199	18	a	a	PRON
admet-169	199	19	)	)	PUNCT
admet-169	199	20	efflux	efflux	NOUN
admet-169	199	21	ratio	ratio	NOUN
admet-169	199	22	control	control	NOUN
admet-169	199	23	1.72	1.72	NUM
admet-169	199	24	±	±	NUM
admet-169	199	25	0.08	0.08	NUM
admet-169	199	26	µm	µm	NOUN
admet-169	199	27	/	/	SYM
admet-169	199	28	s	s	PART
admet-169	199	29	4.51	4.51	NUM
admet-169	199	30	±	±	NUM
admet-169	199	31	0.16	0.16	NUM
admet-169	199	32	µm	µm	NOUN
admet-169	199	33	/	/	SYM
admet-169	199	34	s	s	PART
admet-169	199	35	2.62	2.62	NUM
admet-169	199	36	#	#	SYM
admet-169	199	37	#	#	SYM
admet-169	199	38	#	#	NOUN
admet-169	199	39	+	+	NOUN
admet-169	199	40	ko143	ko143	PROPN
admet-169	199	41	1.23	1.23	NUM
admet-169	199	42	±	±	NUM
admet-169	199	43	0.06	0.06	NUM
admet-169	199	44	µm	µm	ADP
admet-169	199	45	/	/	SYM
admet-169	199	46	s	s	PROPN
admet-169	199	47	*	*	PUNCT
admet-169	199	48	*	*	PUNCT
admet-169	199	49	+	+	ADJ
admet-169	199	50	nan3	nan3	PROPN
admet-169	199	51	2.06	2.06	NUM
admet-169	199	52	±	±	NUM
admet-169	199	53	0.15	0.15	NUM
admet-169	199	54	µm	µm	NOUN
admet-169	199	55	/	/	SYM
admet-169	199	56	s	s	PROPN
admet-169	199	57	*	*	X
admet-169	199	58	where	where	SCONJ
admet-169	199	59	*	*	PUNCT
admet-169	199	60	or	or	CCONJ
admet-169	199	61	#	#	NOUN
admet-169	199	62	not	not	PART
admet-169	199	63	significant	significant	ADJ
admet-169	199	64	paired	pair	VERB
admet-169	199	65	students	student	NOUN
admet-169	199	66	t	t	NOUN
admet-169	199	67	-	-	PUNCT
admet-169	199	68	test	test	NOUN
admet-169	199	69	*	*	PUNCT
admet-169	199	70	*	*	PUNCT
admet-169	199	71	or	or	CCONJ
admet-169	199	72	#	#	SYM
admet-169	199	73	#	#	NOUN
admet-169	199	74	significantly	significantly	ADV
admet-169	199	75	different	different	ADJ
admet-169	199	76	(	(	PUNCT
admet-169	199	77	p>0.05	p>0.05	NOUN
admet-169	199	78	)	)	PUNCT
admet-169	199	79	paired	pair	VERB
admet-169	199	80	students	student	NOUN
admet-169	199	81	t	t	NOUN
admet-169	199	82	-	-	PUNCT
admet-169	199	83	test	test	NOUN
admet-169	199	84	*	*	PUNCT
admet-169	200	1	*	*	PUNCT
admet-169	200	2	*	*	PUNCT
admet-169	200	3	or	or	CCONJ
admet-169	201	1	#	#	SYM
admet-169	201	2	#	#	SYM
admet-169	201	3	#	#	NOUN
admet-169	201	4	highly	highly	ADV
admet-169	201	5	significantly	significantly	ADV
admet-169	201	6	different	different	ADJ
admet-169	201	7	(	(	PUNCT
admet-169	201	8	p>0.01	p>0.01	PROPN
admet-169	201	9	)	)	PUNCT
admet-169	201	10	paired	pair	VERB
admet-169	201	11	students	student	NOUN
admet-169	201	12	t	t	NOUN
admet-169	201	13	-	-	PUNCT
admet-169	201	14	test	test	NOUN
admet-169	201	15	(	(	PUNCT
admet-169	201	16	a	a	NOUN
admet-169	202	1	)	)	PUNCT
admet-169	202	2	(	(	PUNCT
admet-169	202	3	b	b	X
admet-169	202	4	)	)	PUNCT
admet-169	202	5	peters	peters	PROPN
admet-169	202	6	et	et	PROPN
admet-169	202	7	al	al	PROPN
admet-169	202	8	.	.	PROPN
admet-169	202	9	admet	admet	PROPN
admet-169	202	10	&	&	CCONJ
admet-169	202	11	dmpk	dmpk	PROPN
admet-169	202	12	3(1	3(1	NUM
admet-169	202	13	)	)	PUNCT
admet-169	202	14	(	(	PUNCT
admet-169	202	15	2015	2015	NUM
admet-169	202	16	)	)	PUNCT
admet-169	202	17	51	51	NUM
admet-169	202	18	-	-	SYM
admet-169	202	19	67	67	NUM
admet-169	202	20	62	62	NUM
admet-169	202	21	time	time	NOUN
admet-169	202	22	(	(	PUNCT
admet-169	202	23	min	min	NOUN
admet-169	202	24	)	)	PUNCT
admet-169	202	25	a	a	DET
admet-169	202	26	c	c	NOUN
admet-169	202	27	c	c	X
admet-169	202	28	u	u	NOUN
admet-169	202	29	m	m	VERB
admet-169	202	30	u	u	NOUN
admet-169	202	31	la	la	X
admet-169	202	32	ti	ti	X
admet-169	202	33	v	v	ADP
admet-169	202	34	e	e	X
admet-169	202	35	m	m	VERB
admet-169	202	36	a	a	DET
admet-169	202	37	s	s	X
admet-169	202	38	s	s	PROPN
admet-169	202	39	t	t	PROPN
admet-169	202	40	ra	ra	PROPN
admet-169	202	41	n	n	PROPN
admet-169	202	42	s	s	PROPN
admet-169	202	43	p	p	NOUN
admet-169	202	44	o	o	X
admet-169	202	45	rt	rt	PROPN
admet-169	202	46	(	(	PUNCT
admet-169	202	47	p	p	NOUN
admet-169	202	48	m	m	PROPN
admet-169	202	49	o	o	NOUN
admet-169	202	50	l	l	NOUN
admet-169	202	51	)	)	PUNCT
admet-169	202	52	0	0	NUM
admet-169	202	53	50	50	NUM
admet-169	202	54	100	100	NUM
admet-169	202	55	150	150	NUM
admet-169	202	56	200	200	NUM
admet-169	202	57	0	0	NUM
admet-169	202	58	2000	2000	NUM
admet-169	202	59	4000	4000	NUM
admet-169	202	60	6000	6000	NUM
admet-169	202	61	apical	apical	ADJ
admet-169	202	62	to	to	ADP
admet-169	202	63	basolateral	basolateral	ADJ
admet-169	202	64	basolateral	basolateral	NOUN
admet-169	202	65	to	to	ADP
admet-169	202	66	apical	apical	ADJ
admet-169	202	67	apical	apical	NOUN
admet-169	202	68	to	to	ADP
admet-169	202	69	basolateral	basolateral	ADJ
admet-169	202	70	+	+	CCONJ
admet-169	202	71	ko143	ko143	ADJ
admet-169	202	72	apical	apical	ADJ
admet-169	202	73	to	to	ADP
admet-169	202	74	basolateral	basolateral	ADJ
admet-169	202	75	+	+	CCONJ
admet-169	202	76	nan3	nan3	NOUN
admet-169	202	77	figure	figure	NOUN
admet-169	202	78	6	6	NUM
admet-169	202	79	.	.	PUNCT
admet-169	202	80	graphical	graphical	ADJ
admet-169	202	81	representation	representation	NOUN
admet-169	202	82	of	of	ADP
admet-169	202	83	accumulated	accumulate	VERB
admet-169	202	84	drug	drug	NOUN
admet-169	202	85	transport	transport	NOUN
admet-169	202	86	in	in	ADP
admet-169	202	87	the	the	DET
admet-169	202	88	apical	apical	ADJ
admet-169	202	89	to	to	ADP
admet-169	202	90	basolateral	basolateral	NOUN
admet-169	202	91	and	and	CCONJ
admet-169	202	92	the	the	DET
admet-169	202	93	basolateral	basolateral	NOUN
admet-169	202	94	to	to	ADP
admet-169	202	95	apical	apical	ADJ
admet-169	202	96	direction	direction	NOUN
admet-169	202	97	for	for	ADP
admet-169	202	98	erlotinib	erlotinib	NOUN
admet-169	202	99	using	use	VERB
admet-169	202	100	hbss	hbss	NOUN
admet-169	202	101	medium	medium	NOUN
admet-169	202	102	containing	contain	VERB
admet-169	202	103	5	5	NUM
admet-169	202	104	%	%	NOUN
admet-169	202	105	bsa	bsa	PROPN
admet-169	202	106	.	.	PROPN
admet-169	202	107	interference	interference	NOUN
admet-169	202	108	of	of	ADP
admet-169	202	109	the	the	DET
admet-169	202	110	atp	atp	NOUN
admet-169	202	111	based	base	VERB
admet-169	202	112	active	active	ADJ
admet-169	202	113	transport	transport	NOUN
admet-169	202	114	mechanisms	mechanism	NOUN
admet-169	202	115	is	be	AUX
admet-169	202	116	demonstrated	demonstrate	VERB
admet-169	202	117	using	use	VERB
admet-169	202	118	nan3	nan3	PROPN
admet-169	202	119	and	and	CCONJ
admet-169	202	120	ko143	ko143	PROPN
admet-169	202	121	.	.	PUNCT
admet-169	203	1	basolateral	basolateral	ADJ
admet-169	203	2	to	to	ADP
admet-169	203	3	apical	apical	ADJ
admet-169	203	4	(	(	PUNCT
admet-169	203	5	b	b	NOUN
admet-169	203	6	a	a	X
admet-169	203	7	;	;	PUNCT
admet-169	203	8	+5	+5	PROPN
admet-169	203	9	%	%	NOUN
admet-169	203	10	bsa	bsa	NOUN
admet-169	203	11	)	)	PUNCT
admet-169	203	12	to	to	PART
admet-169	203	13	correctly	correctly	ADV
admet-169	203	14	interpret	interpret	VERB
admet-169	203	15	the	the	DET
admet-169	203	16	pharmacokinetic	pharmacokinetic	ADJ
admet-169	203	17	properties	property	NOUN
admet-169	203	18	of	of	ADP
admet-169	203	19	these	these	DET
admet-169	203	20	drugs	drug	NOUN
admet-169	203	21	as	as	SCONJ
admet-169	203	22	determined	determine	VERB
admet-169	203	23	using	use	VERB
admet-169	203	24	the	the	DET
admet-169	203	25	model	model	NOUN
admet-169	203	26	in	in	ADP
admet-169	203	27	the	the	DET
admet-169	203	28	apical	apical	ADJ
admet-169	203	29	to	to	ADP
admet-169	203	30	basolateral	basolateral	ADJ
admet-169	203	31	direction	direction	NOUN
admet-169	203	32	,	,	PUNCT
admet-169	203	33	transport	transport	NOUN
admet-169	203	34	from	from	ADP
admet-169	203	35	the	the	DET
admet-169	203	36	blood	blood	NOUN
admet-169	203	37	or	or	CCONJ
admet-169	203	38	cellular	cellular	ADJ
admet-169	203	39	situation	situation	NOUN
admet-169	203	40	back	back	ADV
admet-169	203	41	to	to	ADP
admet-169	203	42	the	the	DET
admet-169	203	43	epithelial	epithelial	ADJ
admet-169	203	44	side	side	NOUN
admet-169	203	45	of	of	ADP
admet-169	203	46	the	the	DET
admet-169	203	47	membrane	membrane	NOUN
admet-169	203	48	was	be	AUX
admet-169	203	49	also	also	ADV
admet-169	203	50	investigated	investigate	VERB
admet-169	203	51	.	.	PUNCT
admet-169	204	1	gefitinib	gefitinib	NOUN
admet-169	204	2	demonstrated	demonstrate	VERB
admet-169	204	3	very	very	ADV
admet-169	204	4	similar	similar	ADJ
admet-169	204	5	flow	flow	NOUN
admet-169	204	6	characteristics	characteristic	NOUN
admet-169	204	7	in	in	ADP
admet-169	204	8	the	the	DET
admet-169	204	9	b	b	NOUN
admet-169	204	10	a	a	PRON
admet-169	204	11	(	(	PUNCT
admet-169	204	12	papp	papp	NOUN
admet-169	204	13	0.39	0.39	NUM
admet-169	204	14	±	±	NUM
admet-169	204	15	0.038	0.038	NUM
admet-169	204	16	µm/	µm/	X
admet-169	204	17	s	s	NOUN
admet-169	204	18	)	)	PUNCT
admet-169	204	19	direction	direction	NOUN
admet-169	204	20	compared	compare	VERB
admet-169	204	21	to	to	ADP
admet-169	204	22	a	a	DET
admet-169	204	23	–	–	PUNCT
admet-169	204	24	b	b	NOUN
admet-169	204	25	(	(	PUNCT
admet-169	204	26	figure	figure	NOUN
admet-169	204	27	5	5	NUM
admet-169	204	28	)	)	PUNCT
admet-169	204	29	.	.	PUNCT
admet-169	205	1	however	however	ADV
admet-169	205	2	,	,	PUNCT
admet-169	205	3	with	with	ADP
admet-169	205	4	the	the	DET
admet-169	205	5	addition	addition	NOUN
admet-169	205	6	of	of	ADP
admet-169	205	7	nan3	nan3	NOUN
admet-169	205	8	the	the	DET
admet-169	205	9	flow	flow	NOUN
admet-169	205	10	of	of	ADP
admet-169	205	11	gefitinib	gefitinib	NOUN
admet-169	205	12	increased	increase	VERB
admet-169	205	13	significantly	significantly	ADV
admet-169	205	14	(	(	PUNCT
admet-169	205	15	papp	papp	NOUN
admet-169	205	16	–	–	PUNCT
admet-169	205	17	0.57	0.57	NUM
admet-169	205	18	±	±	NUM
admet-169	205	19	0.14	0.14	NUM
admet-169	205	20	µm/	µm/	X
admet-169	205	21	s	s	PROPN
admet-169	205	22	,	,	PUNCT
admet-169	205	23	p	p	X
admet-169	205	24	>	>	X
admet-169	205	25	0.05	0.05	NUM
admet-169	205	26	)	)	PUNCT
admet-169	205	27	,	,	PUNCT
admet-169	205	28	whereas	whereas	SCONJ
admet-169	205	29	with	with	ADP
admet-169	205	30	the	the	DET
admet-169	205	31	addition	addition	NOUN
admet-169	205	32	of	of	ADP
admet-169	205	33	ko143	ko143	NOUN
admet-169	205	34	the	the	DET
admet-169	205	35	flow	flow	NOUN
admet-169	205	36	decreased	decrease	VERB
admet-169	205	37	significantly	significantly	ADV
admet-169	205	38	(	(	PUNCT
admet-169	205	39	papp	papp	NOUN
admet-169	205	40	–	–	PUNCT
admet-169	205	41	0.26	0.26	NUM
admet-169	205	42	±	±	NUM
admet-169	205	43	0.012	0.012	NUM
admet-169	205	44	µm	µm	NOUN
admet-169	205	45	/	/	SYM
admet-169	205	46	s	s	PROPN
admet-169	205	47	,	,	PUNCT
admet-169	205	48	p>0.05	p>0.05	NOUN
admet-169	205	49	)	)	PUNCT
admet-169	205	50	.	.	PUNCT
admet-169	206	1	the	the	DET
admet-169	206	2	net	net	ADJ
admet-169	206	3	efflux	efflux	NOUN
admet-169	206	4	ratio	ratio	NOUN
admet-169	206	5	of	of	ADP
admet-169	206	6	gefitinib	gefitinib	NOUN
admet-169	206	7	was	be	AUX
admet-169	206	8	determined	determine	VERB
admet-169	206	9	to	to	PART
admet-169	206	10	be	be	AUX
admet-169	206	11	less	less	ADJ
admet-169	206	12	than	than	ADP
admet-169	206	13	2	2	NUM
admet-169	206	14	(	(	PUNCT
admet-169	206	15	1.0	1.0	NUM
admet-169	206	16	)	)	PUNCT
admet-169	206	17	which	which	PRON
admet-169	206	18	indicates	indicate	VERB
admet-169	206	19	a	a	DET
admet-169	206	20	predominate	predominate	ADJ
admet-169	206	21	flow	flow	NOUN
admet-169	206	22	in	in	ADP
admet-169	206	23	the	the	DET
admet-169	206	24	basolateral	basolateral	NOUN
admet-169	206	25	to	to	ADP
admet-169	206	26	apical	apical	ADJ
admet-169	206	27	direction	direction	NOUN
admet-169	206	28	.	.	PUNCT
admet-169	207	1	with	with	ADP
admet-169	207	2	the	the	DET
admet-169	207	3	introduction	introduction	NOUN
admet-169	207	4	of	of	ADP
admet-169	207	5	nan3	nan3	PROPN
admet-169	207	6	the	the	DET
admet-169	207	7	efflux	efflux	NOUN
admet-169	207	8	ratio	ratio	NOUN
admet-169	207	9	decreased	decrease	VERB
admet-169	207	10	(	(	PUNCT
admet-169	207	11	0.46	0.46	NUM
admet-169	207	12	)	)	PUNCT
admet-169	207	13	indicating	indicate	VERB
admet-169	207	14	a	a	DET
admet-169	207	15	significant	significant	ADJ
admet-169	207	16	role	role	NOUN
admet-169	207	17	of	of	ADP
admet-169	207	18	several	several	ADJ
admet-169	207	19	active	active	ADJ
admet-169	207	20	atp	atp	NOUN
admet-169	207	21	transport	transport	NOUN
admet-169	207	22	mechanisms	mechanism	NOUN
admet-169	207	23	on	on	ADP
admet-169	207	24	both	both	CCONJ
admet-169	207	25	the	the	DET
admet-169	207	26	apical	apical	ADJ
admet-169	207	27	and	and	CCONJ
admet-169	207	28	basolateral	basolateral	ADJ
admet-169	207	29	membranes	membrane	NOUN
admet-169	207	30	in	in	ADP
admet-169	207	31	the	the	DET
admet-169	207	32	uptake	uptake	NOUN
admet-169	207	33	of	of	ADP
admet-169	207	34	gefitinib	gefitinib	NOUN
admet-169	207	35	.	.	PUNCT
admet-169	208	1	for	for	ADP
admet-169	208	2	erlotinib	erlotinib	NOUN
admet-169	208	3	the	the	DET
admet-169	208	4	b	b	NOUN
admet-169	208	5	a	a	DET
admet-169	208	6	transport	transport	NOUN
admet-169	208	7	was	be	AUX
admet-169	208	8	significantly	significantly	ADV
admet-169	208	9	greater	great	ADJ
admet-169	208	10	in	in	ADP
admet-169	208	11	comparison	comparison	NOUN
admet-169	208	12	to	to	ADP
admet-169	208	13	a	a	DET
admet-169	208	14	b	b	PROPN
admet-169	208	15	(	(	PUNCT
admet-169	208	16	papp	papp	NOUN
admet-169	208	17	–	–	PUNCT
admet-169	208	18	4.51	4.51	NUM
admet-169	208	19	±	±	NUM
admet-169	208	20	0.16	0.16	NUM
admet-169	208	21	µm/	µm/	X
admet-169	208	22	s	s	PART
admet-169	208	23	vs	vs	ADP
admet-169	208	24	papp	papp	NOUN
admet-169	208	25	–	–	PUNCT
admet-169	208	26	1.72	1.72	NUM
admet-169	208	27	±	±	NUM
admet-169	208	28	0.08	0.08	NUM
admet-169	208	29	µm/	µm/	X
admet-169	208	30	s	s	PROPN
admet-169	208	31	,	,	PUNCT
admet-169	208	32	p	p	X
admet-169	208	33	>	>	X
admet-169	208	34	0.009	0.009	NUM
admet-169	208	35	)	)	PUNCT
admet-169	208	36	indicating	indicate	VERB
admet-169	208	37	a	a	DET
admet-169	208	38	very	very	ADV
admet-169	208	39	strong	strong	ADJ
admet-169	208	40	apical	apical	ADJ
admet-169	208	41	efflux	efflux	NOUN
admet-169	208	42	flow	flow	NOUN
admet-169	208	43	as	as	SCONJ
admet-169	208	44	suggested	suggest	VERB
admet-169	208	45	by	by	ADP
admet-169	208	46	the	the	DET
admet-169	208	47	data	datum	NOUN
admet-169	208	48	for	for	ADP
admet-169	208	49	the	the	DET
admet-169	208	50	apical	apical	ADJ
admet-169	208	51	to	to	ADP
admet-169	208	52	basolateral	basolateral	ADJ
admet-169	208	53	flow	flow	NOUN
admet-169	208	54	.	.	PUNCT
admet-169	209	1	cellular	cellular	ADJ
admet-169	209	2	accumulation	accumulation	NOUN
admet-169	209	3	of	of	ADP
admet-169	209	4	erlotinib	erlotinib	NOUN
admet-169	209	5	and	and	CCONJ
admet-169	209	6	gefitinib	gefitinib	VERB
admet-169	209	7	analysis	analysis	NOUN
admet-169	209	8	of	of	ADP
admet-169	209	9	cellular	cellular	ADJ
admet-169	209	10	accumulation	accumulation	NOUN
admet-169	209	11	for	for	ADP
admet-169	209	12	each	each	DET
admet-169	209	13	drug	drug	NOUN
admet-169	209	14	was	be	AUX
admet-169	209	15	performed	perform	VERB
admet-169	209	16	in	in	ADP
admet-169	209	17	the	the	DET
admet-169	209	18	cell	cell	NOUN
admet-169	209	19	pellet	pellet	NOUN
admet-169	209	20	after	after	ADP
admet-169	209	21	completion	completion	NOUN
admet-169	209	22	of	of	ADP
admet-169	209	23	the	the	DET
admet-169	209	24	transport	transport	NOUN
admet-169	209	25	studies	study	NOUN
admet-169	209	26	experiment	experiment	NOUN
admet-169	209	27	(	(	PUNCT
admet-169	209	28	table	table	NOUN
admet-169	209	29	4	4	NUM
admet-169	209	30	)	)	PUNCT
admet-169	209	31	.	.	PUNCT
admet-169	210	1	the	the	DET
admet-169	210	2	accumulation	accumulation	NOUN
admet-169	210	3	of	of	ADP
admet-169	210	4	gefitinib	gefitinib	NOUN
admet-169	210	5	was	be	AUX
admet-169	210	6	consistent	consistent	ADJ
admet-169	210	7	for	for	ADP
admet-169	210	8	both	both	CCONJ
admet-169	210	9	a	a	DET
admet-169	210	10	-	-	PUNCT
admet-169	210	11	b	b	NOUN
admet-169	210	12	and	and	CCONJ
admet-169	210	13	b	b	NOUN
admet-169	210	14	-	-	PUNCT
admet-169	210	15	a	a	DET
admet-169	210	16	transport	transport	NOUN
admet-169	210	17	mechanisms	mechanism	NOUN
admet-169	210	18	observed	observe	VERB
admet-169	210	19	during	during	ADP
admet-169	210	20	the	the	DET
admet-169	210	21	transwell	transwell	NOUN
admet-169	210	22	investigation	investigation	NOUN
admet-169	210	23	.	.	PUNCT
admet-169	211	1	for	for	ADP
admet-169	211	2	a	a	DET
admet-169	211	3	-	-	PUNCT
admet-169	211	4	b	b	NOUN
admet-169	211	5	transport	transport	NOUN
admet-169	211	6	gefitinib	gefitinib	NOUN
admet-169	211	7	accumulation	accumulation	NOUN
admet-169	211	8	was	be	AUX
admet-169	211	9	792.3	792.3	NUM
admet-169	211	10	pmol/	pmol/	NUM
admet-169	211	11	mg	mg	NOUN
admet-169	211	12	protein	protein	NOUN
admet-169	211	13	which	which	PRON
admet-169	211	14	was	be	AUX
admet-169	211	15	lower	low	ADJ
admet-169	211	16	than	than	ADP
admet-169	211	17	the	the	DET
admet-169	211	18	accumulation	accumulation	NOUN
admet-169	211	19	seen	see	VERB
admet-169	211	20	for	for	ADP
admet-169	211	21	b	b	NOUN
admet-169	211	22	-	-	PUNCT
admet-169	211	23	a	a	DET
admet-169	211	24	transport	transport	NOUN
admet-169	211	25	(	(	PUNCT
admet-169	211	26	2059.0	2059.0	NUM
admet-169	211	27	pmol/	pmol/	NUM
admet-169	211	28	mg	mg	NOUN
admet-169	211	29	protein	protein	NOUN
admet-169	211	30	)	)	PUNCT
admet-169	211	31	indicating	indicate	VERB
admet-169	211	32	either	either	CCONJ
admet-169	211	33	a	a	DET
admet-169	211	34	decreased	decrease	VERB
admet-169	211	35	uptake	uptake	NOUN
admet-169	211	36	via	via	ADP
admet-169	211	37	the	the	DET
admet-169	211	38	basolateral	basolateral	ADJ
admet-169	211	39	layer	layer	NOUN
admet-169	211	40	admet	admet	PROPN
admet-169	211	41	&	&	CCONJ
admet-169	211	42	dmpk	dmpk	PROPN
admet-169	211	43	3(1	3(1	NUM
admet-169	211	44	)	)	PUNCT
admet-169	211	45	(	(	PUNCT
admet-169	211	46	2015	2015	NUM
admet-169	211	47	)	)	PUNCT
admet-169	211	48	51	51	NUM
admet-169	211	49	-	-	SYM
admet-169	211	50	67	67	NUM
admet-169	211	51	adaptation	adaptation	NOUN
admet-169	211	52	of	of	ADP
admet-169	211	53	human	human	ADJ
admet-169	211	54	gut	gut	NOUN
admet-169	211	55	epithelial	epithelial	ADJ
admet-169	211	56	model	model	NOUN
admet-169	211	57	doi	doi	NOUN
admet-169	211	58	:	:	PUNCT
admet-169	211	59	10.5599	10.5599	NUM
admet-169	211	60	/	/	SYM
admet-169	211	61	admet.3.1.169	admet.3.1.169	PROPN
admet-169	211	62	63	63	NUM
admet-169	211	63	compared	compare	VERB
admet-169	211	64	to	to	ADP
admet-169	211	65	the	the	DET
admet-169	211	66	apical	apical	ADJ
admet-169	211	67	or	or	CCONJ
admet-169	211	68	a	a	DET
admet-169	211	69	decreased	decrease	VERB
admet-169	211	70	efflux	efflux	NOUN
admet-169	211	71	via	via	ADP
admet-169	211	72	the	the	DET
admet-169	211	73	apical	apical	ADJ
admet-169	211	74	layer	layer	NOUN
admet-169	211	75	compared	compare	VERB
admet-169	211	76	to	to	ADP
admet-169	211	77	the	the	DET
admet-169	211	78	basolateral	basolateral	NOUN
admet-169	211	79	.	.	PUNCT
admet-169	212	1	addition	addition	NOUN
admet-169	212	2	of	of	ADP
admet-169	212	3	nan3	nan3	NOUN
admet-169	212	4	to	to	ADP
admet-169	212	5	the	the	DET
admet-169	212	6	a	a	PRON
admet-169	212	7	-	-	PUNCT
admet-169	212	8	b	b	NOUN
admet-169	212	9	donor	donor	NOUN
admet-169	212	10	compartment	compartment	NOUN
admet-169	212	11	during	during	ADP
admet-169	212	12	transport	transport	NOUN
admet-169	212	13	slightly	slightly	ADV
admet-169	212	14	reduced	reduce	VERB
admet-169	212	15	cellular	cellular	ADJ
admet-169	212	16	accumulation	accumulation	NOUN
admet-169	212	17	(	(	PUNCT
admet-169	212	18	22.9	22.9	NUM
admet-169	212	19	%	%	NOUN
admet-169	212	20	)	)	PUNCT
admet-169	212	21	;	;	PUNCT
admet-169	212	22	while	while	SCONJ
admet-169	212	23	the	the	DET
admet-169	212	24	addition	addition	NOUN
admet-169	212	25	of	of	ADP
admet-169	212	26	ko143	ko143	PROPN
admet-169	212	27	had	have	VERB
admet-169	212	28	a	a	DET
admet-169	212	29	more	more	ADV
admet-169	212	30	significant	significant	ADJ
admet-169	212	31	lowering	lowering	NOUN
admet-169	212	32	effect	effect	NOUN
admet-169	212	33	(	(	PUNCT
admet-169	212	34	45.5	45.5	NUM
admet-169	212	35	%	%	NOUN
admet-169	212	36	)	)	PUNCT
admet-169	212	37	.	.	PUNCT
admet-169	213	1	for	for	ADP
admet-169	213	2	b	b	NOUN
admet-169	213	3	-	-	PUNCT
admet-169	213	4	a	a	DET
admet-169	213	5	transport	transport	NOUN
admet-169	213	6	addition	addition	NOUN
admet-169	213	7	of	of	ADP
admet-169	213	8	nan3	nan3	PROPN
admet-169	213	9	led	lead	VERB
admet-169	213	10	to	to	ADP
admet-169	213	11	a	a	DET
admet-169	213	12	similar	similar	ADJ
admet-169	213	13	decrease	decrease	NOUN
admet-169	213	14	in	in	ADP
admet-169	213	15	accumulation	accumulation	NOUN
admet-169	213	16	(	(	PUNCT
admet-169	213	17	28	28	NUM
admet-169	213	18	%	%	NOUN
admet-169	213	19	)	)	PUNCT
admet-169	214	1	but	but	CCONJ
admet-169	214	2	ko143	ko143	PROPN
admet-169	214	3	had	have	VERB
admet-169	214	4	a	a	DET
admet-169	214	5	significantly	significantly	ADV
admet-169	214	6	lower	low	ADJ
admet-169	214	7	difference	difference	NOUN
admet-169	214	8	in	in	ADP
admet-169	214	9	accumulation	accumulation	NOUN
admet-169	214	10	(	(	PUNCT
admet-169	214	11	17.8	17.8	NUM
admet-169	214	12	%	%	NOUN
admet-169	214	13	)	)	PUNCT
admet-169	214	14	.	.	PUNCT
admet-169	215	1	these	these	DET
admet-169	215	2	results	result	NOUN
admet-169	215	3	indicate	indicate	VERB
admet-169	215	4	that	that	SCONJ
admet-169	215	5	the	the	DET
admet-169	215	6	measured	measured	ADJ
admet-169	215	7	papp	papp	NOUN
admet-169	215	8	for	for	ADP
admet-169	215	9	gefitinib	gefitinib	NOUN
admet-169	215	10	transport	transport	NOUN
admet-169	215	11	is	be	AUX
admet-169	215	12	due	due	ADJ
admet-169	215	13	to	to	ADP
admet-169	215	14	a	a	DET
admet-169	215	15	combination	combination	NOUN
admet-169	215	16	of	of	ADP
admet-169	215	17	both	both	CCONJ
admet-169	215	18	passive	passive	ADJ
admet-169	215	19	and	and	CCONJ
admet-169	215	20	multiple	multiple	ADJ
admet-169	215	21	active	active	ADJ
admet-169	215	22	processes	process	NOUN
admet-169	215	23	located	locate	VERB
admet-169	215	24	on	on	ADP
admet-169	215	25	differing	differ	VERB
admet-169	215	26	membranes	membrane	NOUN
admet-169	215	27	.	.	PUNCT
admet-169	216	1	table	table	NOUN
admet-169	216	2	4	4	NUM
admet-169	216	3	.	.	PUNCT
admet-169	217	1	the	the	DET
admet-169	217	2	cellular	cellular	ADJ
admet-169	217	3	accumulation	accumulation	NOUN
admet-169	217	4	of	of	ADP
admet-169	217	5	gefitinib	gefitinib	NOUN
admet-169	217	6	and	and	CCONJ
admet-169	217	7	erlotinib	erlotinib	NOUN
admet-169	217	8	.	.	PUNCT
admet-169	218	1	concentration	concentration	NOUN
admet-169	218	2	of	of	ADP
admet-169	218	3	drug	drug	NOUN
admet-169	218	4	was	be	AUX
admet-169	218	5	determined	determine	VERB
admet-169	218	6	in	in	ADP
admet-169	218	7	the	the	DET
admet-169	218	8	recovered	recovered	ADJ
admet-169	218	9	cells	cell	NOUN
admet-169	218	10	of	of	ADP
admet-169	218	11	the	the	DET
admet-169	218	12	monolayer	monolayer	NOUN
admet-169	218	13	at	at	ADP
admet-169	218	14	the	the	DET
admet-169	218	15	end	end	NOUN
admet-169	218	16	of	of	ADP
admet-169	218	17	the	the	DET
admet-169	218	18	transwell	transwell	NOUN
admet-169	218	19	experiment	experiment	NOUN
admet-169	218	20	(	(	PUNCT
admet-169	218	21	180	180	NUM
admet-169	218	22	min	min	NOUN
admet-169	218	23	)	)	PUNCT
admet-169	218	24	.	.	PUNCT
admet-169	219	1	gefitinib	gefitinib	NOUN
admet-169	219	2	(	(	PUNCT
admet-169	219	3	pmol	pmol	X
admet-169	219	4	/	/	SYM
admet-169	219	5	mg	mg	PROPN
admet-169	219	6	protein	protein	NOUN
admet-169	219	7	)	)	PUNCT
admet-169	219	8	erlotinib	erlotinib	NOUN
admet-169	219	9	(	(	PUNCT
admet-169	219	10	pmol	pmol	PROPN
admet-169	219	11	/	/	SYM
admet-169	219	12	mg	mg	PROPN
admet-169	219	13	protein	protein	NOUN
admet-169	219	14	)	)	PUNCT
admet-169	219	15	a	a	DET
admet-169	219	16	–	–	PUNCT
admet-169	219	17	b	b	PROPN
admet-169	219	18	b	b	X
admet-169	219	19	–	–	PUNCT
admet-169	219	20	a	a	DET
admet-169	219	21	a	a	NOUN
admet-169	219	22	–	–	PUNCT
admet-169	219	23	b	b	PROPN
admet-169	219	24	b	b	NOUN
admet-169	219	25	a	a	DET
admet-169	219	26	control	control	NOUN
admet-169	219	27	(	(	PUNCT
admet-169	219	28	20	20	NUM
admet-169	219	29	µm	µm	NOUN
admet-169	219	30	)	)	PUNCT
admet-169	219	31	792.3	792.3	NUM
admet-169	219	32	±	±	NUM
admet-169	219	33	178.8	178.8	NUM
admet-169	219	34	2059	2059	NUM
admet-169	219	35	±	±	NUM
admet-169	219	36	256.5	256.5	NUM
admet-169	219	37	741.1	741.1	NUM
admet-169	219	38	±	±	NUM
admet-169	219	39	88.8	88.8	NUM
admet-169	219	40	674.6	674.6	NUM
admet-169	219	41	±	±	NUM
admet-169	219	42	71.6	71.6	NUM
admet-169	219	43	20	20	NUM
admet-169	219	44	µm	µm	ADP
admet-169	219	45	+	+	CCONJ
admet-169	219	46	ko143	ko143	PROPN
admet-169	219	47	431.7	431.7	NUM
admet-169	219	48	±	±	NUM
admet-169	219	49	165.7	165.7	NUM
admet-169	219	50	1692	1692	NUM
admet-169	219	51	±	±	NUM
admet-169	219	52	242.6	242.6	NUM
admet-169	219	53	451.6	451.6	NUM
admet-169	219	54	±	±	NUM
admet-169	219	55	81.7	81.7	NUM
admet-169	219	56	no	no	DET
admet-169	219	57	data	datum	NOUN
admet-169	219	58	20	20	NUM
admet-169	219	59	µm	µm	NOUN
admet-169	219	60	+	+	NOUN
admet-169	219	61	nan3	nan3	PROPN
admet-169	219	62	611.3	611.3	NUM
admet-169	219	63	±	±	NUM
admet-169	219	64	106.2	106.2	NUM
admet-169	219	65	1475	1475	NUM
admet-169	219	66	±	±	NUM
admet-169	219	67	156.9	156.9	NUM
admet-169	219	68	835.8	835.8	NUM
admet-169	219	69	±	±	NUM
admet-169	219	70	44.2	44.2	NUM
admet-169	219	71	erlotinib	erlotinib	NOUN
admet-169	219	72	demonstrated	demonstrate	VERB
admet-169	219	73	a	a	DET
admet-169	219	74	similar	similar	ADJ
admet-169	219	75	accumulation	accumulation	NOUN
admet-169	219	76	in	in	ADP
admet-169	219	77	both	both	CCONJ
admet-169	219	78	a	a	DET
admet-169	219	79	-	-	PUNCT
admet-169	219	80	b	b	NOUN
admet-169	219	81	and	and	CCONJ
admet-169	219	82	b	b	NOUN
admet-169	219	83	-	-	PUNCT
admet-169	219	84	a	a	PRON
admet-169	219	85	directions	direction	NOUN
admet-169	219	86	without	without	ADP
admet-169	219	87	addition	addition	NOUN
admet-169	219	88	of	of	ADP
admet-169	219	89	any	any	DET
admet-169	219	90	inhibitors	inhibitor	NOUN
admet-169	219	91	.	.	PUNCT
admet-169	220	1	with	with	ADP
admet-169	220	2	the	the	DET
admet-169	220	3	addition	addition	NOUN
admet-169	220	4	of	of	ADP
admet-169	220	5	nan3	nan3	NOUN
admet-169	220	6	to	to	ADP
admet-169	220	7	the	the	DET
admet-169	220	8	apical	apical	ADJ
admet-169	220	9	compartment	compartment	NOUN
admet-169	220	10	during	during	ADP
admet-169	220	11	a	a	DET
admet-169	220	12	-	-	PUNCT
admet-169	220	13	b	b	NOUN
admet-169	220	14	transport	transport	NOUN
admet-169	220	15	an	an	DET
admet-169	220	16	increase	increase	NOUN
admet-169	220	17	in	in	ADP
admet-169	220	18	cellular	cellular	ADJ
admet-169	220	19	accumulation	accumulation	NOUN
admet-169	220	20	is	be	AUX
admet-169	220	21	seen	see	VERB
admet-169	220	22	(	(	PUNCT
admet-169	220	23	12.8	12.8	NUM
admet-169	220	24	%	%	NOUN
admet-169	220	25	)	)	PUNCT
admet-169	220	26	,	,	PUNCT
admet-169	220	27	in	in	ADP
admet-169	220	28	contrast	contrast	NOUN
admet-169	220	29	the	the	DET
admet-169	220	30	addition	addition	NOUN
admet-169	220	31	of	of	ADP
admet-169	220	32	ko143	ko143	PROPN
admet-169	220	33	reduced	reduce	VERB
admet-169	220	34	the	the	DET
admet-169	220	35	cellular	cellular	ADJ
admet-169	220	36	accumulation	accumulation	NOUN
admet-169	220	37	similar	similar	ADJ
admet-169	220	38	to	to	ADP
admet-169	220	39	that	that	PRON
admet-169	220	40	of	of	ADP
admet-169	220	41	gefitinib	gefitinib	NOUN
admet-169	220	42	(	(	PUNCT
admet-169	220	43	39.1	39.1	NUM
admet-169	220	44	%	%	NOUN
admet-169	220	45	)	)	PUNCT
admet-169	220	46	.	.	PUNCT
admet-169	221	1	discussion	discussion	NOUN
admet-169	221	2	in	in	ADP
admet-169	221	3	this	this	DET
admet-169	221	4	paper	paper	NOUN
admet-169	221	5	we	we	PRON
admet-169	221	6	described	describe	VERB
admet-169	221	7	the	the	DET
admet-169	221	8	optimization	optimization	NOUN
admet-169	221	9	and	and	CCONJ
admet-169	221	10	validation	validation	NOUN
admet-169	221	11	of	of	ADP
admet-169	221	12	a	a	DET
admet-169	221	13	caco-2	caco-2	NUM
admet-169	221	14	gut	gut	VERB
admet-169	221	15	epithelial	epithelial	ADJ
admet-169	221	16	model	model	NOUN
admet-169	221	17	system	system	NOUN
admet-169	221	18	in	in	ADP
admet-169	221	19	order	order	NOUN
admet-169	221	20	to	to	PART
admet-169	221	21	simulate	simulate	VERB
admet-169	221	22	uptake	uptake	ADJ
admet-169	221	23	characteristics	characteristic	NOUN
admet-169	221	24	of	of	ADP
admet-169	221	25	the	the	DET
admet-169	221	26	family	family	NOUN
admet-169	221	27	of	of	ADP
admet-169	221	28	compounds	compound	NOUN
admet-169	221	29	classified	classify	VERB
admet-169	221	30	under	under	ADP
admet-169	221	31	the	the	DET
admet-169	221	32	name	name	NOUN
admet-169	221	33	of	of	ADP
admet-169	221	34	tyrosine	tyrosine	NOUN
admet-169	221	35	kinase	kinase	PROPN
admet-169	221	36	inhibitors	inhibitor	NOUN
admet-169	221	37	.	.	PUNCT
admet-169	222	1	this	this	DET
admet-169	222	2	series	series	NOUN
admet-169	222	3	of	of	ADP
admet-169	222	4	small	small	ADJ
admet-169	222	5	molecule	molecule	NOUN
admet-169	222	6	inhibitors	inhibitor	NOUN
admet-169	222	7	have	have	AUX
admet-169	222	8	demonstrated	demonstrate	VERB
admet-169	222	9	strong	strong	ADJ
admet-169	222	10	in	in	ADP
admet-169	222	11	vitro	vitro	X
admet-169	222	12	chemotherapy	chemotherapy	NOUN
admet-169	222	13	potential	potential	NOUN
admet-169	222	14	but	but	CCONJ
admet-169	222	15	many	many	ADJ
admet-169	222	16	exhibit	exhibit	VERB
admet-169	222	17	limited	limit	VERB
admet-169	222	18	to	to	ADP
admet-169	222	19	no	no	DET
admet-169	222	20	clinical	clinical	ADJ
admet-169	222	21	effect	effect	NOUN
admet-169	222	22	[	[	X
admet-169	222	23	27	27	NUM
admet-169	222	24	]	]	PUNCT
admet-169	222	25	.	.	PUNCT
admet-169	223	1	the	the	DET
admet-169	223	2	phase	phase	NOUN
admet-169	223	3	2	2	NUM
admet-169	223	4	and	and	CCONJ
admet-169	223	5	phase	phase	NOUN
admet-169	223	6	3	3	NUM
admet-169	223	7	trial	trial	NOUN
admet-169	223	8	failure	failure	NOUN
admet-169	223	9	rates	rate	NOUN
admet-169	223	10	for	for	ADP
admet-169	223	11	these	these	DET
admet-169	223	12	compounds	compound	NOUN
admet-169	223	13	is	be	AUX
admet-169	223	14	very	very	ADV
admet-169	223	15	high	high	ADJ
admet-169	223	16	with	with	ADP
admet-169	223	17	regard	regard	NOUN
admet-169	223	18	to	to	ADP
admet-169	223	19	solid	solid	ADJ
admet-169	223	20	tumours	tumour	NOUN
admet-169	223	21	.	.	PUNCT
admet-169	224	1	tkis	tkis	PROPN
admet-169	224	2	are	be	AUX
admet-169	224	3	referred	refer	VERB
admet-169	224	4	to	to	ADP
admet-169	224	5	as	as	ADP
admet-169	224	6	“	"	PUNCT
admet-169	224	7	targeted	targeted	ADJ
admet-169	224	8	chemotherapy	chemotherapy	NOUN
admet-169	224	9	”	"	PUNCT
admet-169	224	10	drugs	drug	NOUN
admet-169	224	11	but	but	CCONJ
admet-169	224	12	have	have	AUX
admet-169	224	13	been	be	AUX
admet-169	224	14	shown	show	VERB
admet-169	224	15	to	to	PART
admet-169	224	16	actually	actually	ADV
admet-169	224	17	inhibiting	inhibit	VERB
admet-169	224	18	a	a	DET
admet-169	224	19	broad	broad	ADJ
admet-169	224	20	range	range	NOUN
admet-169	224	21	of	of	ADP
admet-169	224	22	targets	target	NOUN
admet-169	224	23	which	which	PRON
admet-169	224	24	can	can	AUX
admet-169	224	25	lead	lead	VERB
admet-169	224	26	to	to	ADP
admet-169	224	27	toxicity	toxicity	NOUN
admet-169	224	28	and	and	CCONJ
admet-169	224	29	tumour	tumour	NOUN
admet-169	224	30	resistance	resistance	NOUN
admet-169	225	1	[	[	X
admet-169	225	2	27	27	NUM
admet-169	225	3	]	]	PUNCT
admet-169	225	4	.	.	PUNCT
admet-169	226	1	however	however	ADV
admet-169	226	2	,	,	PUNCT
admet-169	226	3	lack	lack	NOUN
admet-169	226	4	of	of	ADP
admet-169	226	5	target	target	NOUN
admet-169	226	6	specificity	specificity	NOUN
admet-169	226	7	does	do	AUX
admet-169	226	8	not	not	PART
admet-169	226	9	completely	completely	ADV
admet-169	226	10	explain	explain	VERB
admet-169	226	11	the	the	DET
admet-169	226	12	lack	lack	NOUN
admet-169	226	13	of	of	ADP
admet-169	226	14	clinical	clinical	ADJ
admet-169	226	15	efficacy	efficacy	NOUN
admet-169	226	16	.	.	PUNCT
admet-169	227	1	hence	hence	ADV
admet-169	227	2	we	we	PRON
admet-169	227	3	developed	develop	VERB
admet-169	227	4	an	an	DET
admet-169	227	5	adaptable	adaptable	ADJ
admet-169	227	6	model	model	NOUN
admet-169	227	7	system	system	NOUN
admet-169	227	8	to	to	PART
admet-169	227	9	investigate	investigate	VERB
admet-169	227	10	the	the	DET
admet-169	227	11	pharmacokinetic	pharmacokinetic	ADJ
admet-169	227	12	uptake	uptake	NOUN
admet-169	227	13	of	of	ADP
admet-169	227	14	these	these	DET
admet-169	227	15	molecules	molecule	NOUN
admet-169	227	16	;	;	PUNCT
admet-169	227	17	we	we	PRON
admet-169	227	18	used	use	VERB
admet-169	227	19	the	the	DET
admet-169	227	20	registered	register	VERB
admet-169	227	21	compounds	compound	NOUN
admet-169	227	22	gefitinib	gefitinib	NOUN
admet-169	227	23	and	and	CCONJ
admet-169	227	24	erlotinib	erlotinib	NOUN
admet-169	227	25	to	to	PART
admet-169	227	26	validate	validate	VERB
admet-169	227	27	the	the	DET
admet-169	227	28	models	model	NOUN
admet-169	227	29	applicability	applicability	NOUN
admet-169	227	30	[	[	X
admet-169	227	31	28	28	NUM
admet-169	227	32	]	]	PUNCT
admet-169	227	33	.	.	PUNCT
admet-169	228	1	the	the	DET
admet-169	228	2	first	first	ADJ
admet-169	228	3	major	major	ADJ
admet-169	228	4	point	point	NOUN
admet-169	228	5	of	of	ADP
admet-169	228	6	the	the	DET
admet-169	228	7	caco-2	caco-2	NUM
admet-169	228	8	model	model	NOUN
admet-169	228	9	system	system	NOUN
admet-169	228	10	is	be	AUX
admet-169	228	11	the	the	DET
admet-169	228	12	time	time	NOUN
admet-169	228	13	in	in	ADP
admet-169	228	14	which	which	PRON
admet-169	228	15	the	the	DET
admet-169	228	16	monolayers	monolayer	NOUN
admet-169	228	17	need	need	VERB
admet-169	228	18	to	to	PART
admet-169	228	19	be	be	AUX
admet-169	228	20	prepared	prepare	VERB
admet-169	228	21	,	,	PUNCT
admet-169	228	22	traditionally	traditionally	ADV
admet-169	228	23	this	this	PRON
admet-169	228	24	has	have	AUX
admet-169	228	25	been	be	AUX
admet-169	228	26	a	a	DET
admet-169	228	27	time	time	NOUN
admet-169	228	28	consuming	consume	VERB
admet-169	228	29	21	21	NUM
admet-169	228	30	days	day	NOUN
admet-169	228	31	.	.	PUNCT
admet-169	229	1	to	to	PART
admet-169	229	2	shorten	shorten	VERB
admet-169	229	3	this	this	PRON
admet-169	229	4	we	we	PRON
admet-169	229	5	utilized	utilize	VERB
admet-169	229	6	a	a	DET
admet-169	229	7	commercial	commercial	ADJ
admet-169	229	8	system	system	NOUN
admet-169	229	9	from	from	ADP
admet-169	229	10	bd	bd	PROPN
admet-169	229	11	biosciences	bioscience	NOUN
admet-169	229	12	that	that	PRON
admet-169	229	13	required	require	VERB
admet-169	229	14	only	only	ADV
admet-169	229	15	a	a	DET
admet-169	229	16	3	3	NUM
admet-169	229	17	day	day	NOUN
admet-169	229	18	growth	growth	NOUN
admet-169	229	19	period	period	NOUN
admet-169	229	20	.	.	PUNCT
admet-169	230	1	monolayers	monolayer	NOUN
admet-169	230	2	using	use	VERB
admet-169	230	3	this	this	DET
admet-169	230	4	system	system	NOUN
admet-169	230	5	have	have	AUX
admet-169	230	6	been	be	AUX
admet-169	230	7	shown	show	VERB
admet-169	230	8	to	to	PART
admet-169	230	9	have	have	VERB
admet-169	230	10	characteristics	characteristic	NOUN
admet-169	230	11	identical	identical	ADJ
admet-169	230	12	to	to	ADP
admet-169	230	13	those	those	PRON
admet-169	230	14	grown	grow	VERB
admet-169	230	15	over	over	ADP
admet-169	230	16	21	21	NUM
admet-169	230	17	days	day	NOUN
admet-169	230	18	[	[	X
admet-169	230	19	24	24	NUM
admet-169	230	20	]	]	PUNCT
admet-169	230	21	.	.	PUNCT
admet-169	231	1	initial	initial	ADJ
admet-169	231	2	testing	testing	NOUN
admet-169	231	3	demonstrated	demonstrate	VERB
admet-169	231	4	several	several	ADJ
admet-169	231	5	problems	problem	NOUN
admet-169	231	6	using	use	VERB
admet-169	231	7	this	this	DET
admet-169	231	8	system	system	NOUN
admet-169	231	9	for	for	ADP
admet-169	231	10	the	the	DET
admet-169	231	11	investigation	investigation	NOUN
admet-169	231	12	of	of	ADP
admet-169	231	13	gefitinib	gefitinib	NOUN
admet-169	231	14	or	or	CCONJ
admet-169	231	15	erlotinib	erlotinib	NOUN
admet-169	231	16	.	.	PUNCT
admet-169	232	1	it	it	PRON
admet-169	232	2	was	be	AUX
admet-169	232	3	observed	observe	VERB
admet-169	232	4	that	that	SCONJ
admet-169	232	5	the	the	DET
admet-169	232	6	donor	donor	NOUN
admet-169	232	7	compartment	compartment	NOUN
admet-169	232	8	concentrations	concentration	NOUN
admet-169	232	9	were	be	AUX
admet-169	232	10	not	not	PART
admet-169	232	11	stable	stable	ADJ
admet-169	232	12	during	during	ADP
admet-169	232	13	the	the	DET
admet-169	232	14	course	course	NOUN
admet-169	232	15	of	of	ADP
admet-169	232	16	the	the	DET
admet-169	232	17	experiment	experiment	NOUN
admet-169	232	18	showing	show	VERB
admet-169	232	19	decreases	decrease	NOUN
admet-169	232	20	of	of	ADP
admet-169	232	21	60	60	NUM
admet-169	232	22	%	%	NOUN
admet-169	232	23	or	or	CCONJ
admet-169	232	24	more	more	ADJ
admet-169	232	25	of	of	ADP
admet-169	232	26	the	the	DET
admet-169	232	27	total	total	ADJ
admet-169	232	28	drug	drug	NOUN
admet-169	232	29	added	add	VERB
admet-169	232	30	to	to	ADP
admet-169	232	31	the	the	DET
admet-169	232	32	culture	culture	NOUN
admet-169	232	33	medium	medium	NOUN
admet-169	232	34	.	.	PUNCT
admet-169	233	1	peters	peters	PROPN
admet-169	233	2	et	et	PROPN
admet-169	233	3	al	al	PROPN
admet-169	233	4	.	.	PROPN
admet-169	233	5	admet	admet	PROPN
admet-169	233	6	&	&	CCONJ
admet-169	233	7	dmpk	dmpk	PROPN
admet-169	233	8	3(1	3(1	NUM
admet-169	233	9	)	)	PUNCT
admet-169	233	10	(	(	PUNCT
admet-169	233	11	2015	2015	NUM
admet-169	233	12	)	)	PUNCT
admet-169	233	13	51	51	NUM
admet-169	233	14	-	-	SYM
admet-169	233	15	67	67	NUM
admet-169	233	16	64	64	NUM
admet-169	233	17	investigation	investigation	NOUN
admet-169	233	18	into	into	ADP
admet-169	233	19	this	this	DET
admet-169	233	20	phenomenon	phenomenon	NOUN
admet-169	233	21	indicated	indicate	VERB
admet-169	233	22	that	that	SCONJ
admet-169	233	23	this	this	PRON
admet-169	233	24	was	be	AUX
admet-169	233	25	due	due	ADJ
admet-169	233	26	to	to	ADP
admet-169	233	27	the	the	DET
admet-169	233	28	buffer	buffer	NOUN
admet-169	233	29	matrix	matrix	NOUN
admet-169	233	30	used	use	VERB
admet-169	233	31	(	(	PUNCT
admet-169	233	32	hbss),however	hbss),however	PROPN
admet-169	233	33	,	,	PUNCT
admet-169	233	34	this	this	DET
admet-169	233	35	buffer	buffer	NOUN
admet-169	233	36	contained	contain	VERB
admet-169	233	37	only	only	ADV
admet-169	233	38	ca	can	AUX
admet-169	233	39	2	2	NUM
admet-169	233	40	+	+	NUM
admet-169	233	41	and	and	CCONJ
admet-169	233	42	mg	mg	PROPN
admet-169	233	43	2	2	NUM
admet-169	233	44	+	+	NUM
admet-169	233	45	salts	salt	NOUN
admet-169	233	46	and	and	CCONJ
admet-169	233	47	no	no	DET
admet-169	233	48	degradation	degradation	NOUN
admet-169	233	49	of	of	ADP
admet-169	233	50	the	the	DET
admet-169	233	51	compounds	compound	NOUN
admet-169	233	52	could	could	AUX
admet-169	233	53	be	be	AUX
admet-169	233	54	observed	observe	VERB
admet-169	233	55	.	.	PUNCT
admet-169	234	1	mass	mass	ADJ
admet-169	234	2	spectral	spectral	ADJ
admet-169	234	3	analysis	analysis	NOUN
admet-169	234	4	of	of	ADP
admet-169	234	5	gefitinib	gefitinib	NOUN
admet-169	234	6	and	and	CCONJ
admet-169	234	7	erlotinib	erlotinib	NOUN
admet-169	234	8	incubated	incubate	VERB
admet-169	234	9	at	at	ADP
admet-169	234	10	37	37	NUM
admet-169	234	11	°	°	ADP
admet-169	234	12	c	c	NOUN
admet-169	234	13	in	in	ADP
admet-169	234	14	hbss	hbss	NOUN
admet-169	234	15	buffer	buffer	NOUN
admet-169	234	16	suggested	suggest	VERB
admet-169	234	17	that	that	SCONJ
admet-169	234	18	instead	instead	ADV
admet-169	234	19	a	a	DET
admet-169	234	20	chelation	chelation	NOUN
admet-169	234	21	effect	effect	NOUN
admet-169	234	22	was	be	AUX
admet-169	234	23	the	the	DET
admet-169	234	24	cause	cause	NOUN
admet-169	234	25	of	of	ADP
admet-169	234	26	the	the	DET
admet-169	234	27	loss	loss	NOUN
admet-169	234	28	of	of	ADP
admet-169	234	29	concentration	concentration	NOUN
admet-169	234	30	.	.	PUNCT
admet-169	235	1	yamashita	yamashita	PROPN
admet-169	235	2	et	et	PROPN
admet-169	235	3	al	al	PROPN
admet-169	235	4	reported	report	VERB
admet-169	235	5	that	that	SCONJ
admet-169	235	6	the	the	DET
admet-169	235	7	relative	relative	ADJ
admet-169	235	8	importance	importance	NOUN
admet-169	235	9	of	of	ADP
admet-169	235	10	considering	consider	VERB
admet-169	235	11	the	the	DET
admet-169	235	12	“	"	PUNCT
admet-169	235	13	physiological	physiological	ADJ
admet-169	235	14	conditions	condition	NOUN
admet-169	235	15	of	of	ADP
admet-169	235	16	the	the	DET
admet-169	235	17	in	in	ADP
admet-169	235	18	vivo	vivo	ADJ
admet-169	235	19	drug	drug	NOUN
admet-169	235	20	absorption	absorption	NOUN
admet-169	235	21	when	when	SCONJ
admet-169	235	22	optimizing	optimize	VERB
admet-169	235	23	the	the	DET
admet-169	235	24	in	in	X
admet-169	235	25	vitro	vitro	X
admet-169	235	26	experimental	experimental	ADJ
admet-169	235	27	conditions	condition	NOUN
admet-169	235	28	”	"	PUNCT
admet-169	235	29	.	.	PUNCT
admet-169	236	1	the	the	DET
admet-169	236	2	reference	reference	NOUN
admet-169	236	3	reports	report	VERB
admet-169	236	4	that	that	SCONJ
admet-169	236	5	the	the	DET
admet-169	236	6	addition	addition	NOUN
admet-169	236	7	of	of	ADP
admet-169	236	8	bsa	bsa	PROPN
admet-169	236	9	to	to	ADP
admet-169	236	10	the	the	DET
admet-169	236	11	medium	medium	NOUN
admet-169	236	12	improved	improve	VERB
admet-169	236	13	the	the	DET
admet-169	236	14	transport	transport	NOUN
admet-169	236	15	of	of	ADP
admet-169	236	16	high	high	ADJ
admet-169	236	17	lipophilic	lipophilic	ADJ
admet-169	236	18	drugs	drug	NOUN
admet-169	236	19	with	with	ADP
admet-169	236	20	poor	poor	ADJ
admet-169	236	21	medium	medium	NOUN
admet-169	236	22	solubility	solubility	NOUN
admet-169	236	23	across	across	ADP
admet-169	236	24	the	the	DET
admet-169	236	25	caco-2	caco-2	NUM
admet-169	236	26	monolayer	monolayer	NOUN
admet-169	236	27	[	[	X
admet-169	236	28	29	29	NUM
admet-169	236	29	]	]	PUNCT
admet-169	236	30	.	.	PUNCT
admet-169	237	1	both	both	DET
admet-169	237	2	gefitinib	gefitinib	NOUN
admet-169	237	3	and	and	CCONJ
admet-169	237	4	erlotinib	erlotinib	NOUN
admet-169	237	5	are	be	AUX
admet-169	237	6	poorly	poorly	ADV
admet-169	237	7	soluble	soluble	ADJ
admet-169	237	8	in	in	ADP
admet-169	237	9	aqueous	aqueous	ADJ
admet-169	237	10	solutions	solution	NOUN
admet-169	237	11	and	and	CCONJ
admet-169	237	12	are	be	AUX
admet-169	237	13	very	very	ADV
admet-169	237	14	highly	highly	ADV
admet-169	237	15	bound	bind	VERB
admet-169	237	16	to	to	ADP
admet-169	237	17	proteins	protein	NOUN
admet-169	237	18	when	when	SCONJ
admet-169	237	19	circulating	circulate	VERB
admet-169	237	20	in	in	ADP
admet-169	237	21	the	the	DET
admet-169	237	22	human	human	ADJ
admet-169	237	23	system	system	NOUN
admet-169	237	24	,	,	PUNCT
admet-169	237	25	hence	hence	ADV
admet-169	237	26	by	by	ADP
admet-169	237	27	the	the	DET
admet-169	237	28	simple	simple	ADJ
admet-169	237	29	addition	addition	NOUN
admet-169	237	30	of	of	ADP
admet-169	237	31	5	5	NUM
admet-169	237	32	%	%	NOUN
admet-169	237	33	bsa	bsa	NOUN
admet-169	237	34	we	we	PRON
admet-169	237	35	could	could	AUX
admet-169	237	36	more	more	ADV
admet-169	237	37	closely	closely	ADV
admet-169	237	38	mimic	mimic	VERB
admet-169	237	39	the	the	DET
admet-169	237	40	“	"	PUNCT
admet-169	237	41	real	real	ADJ
admet-169	237	42	situation	situation	NOUN
admet-169	237	43	”	"	PUNCT
admet-169	237	44	.	.	PUNCT
admet-169	238	1	more	more	ADV
admet-169	238	2	importantly	importantly	ADV
admet-169	238	3	5	5	NUM
admet-169	238	4	%	%	NOUN
admet-169	238	5	bsa	bsa	NOUN
admet-169	238	6	in	in	ADP
admet-169	238	7	the	the	DET
admet-169	238	8	medium	medium	NOUN
admet-169	238	9	stabilized	stabilize	VERB
admet-169	238	10	the	the	DET
admet-169	238	11	drugs	drug	NOUN
admet-169	238	12	while	while	SCONJ
admet-169	238	13	in	in	ADP
admet-169	238	14	solution	solution	NOUN
admet-169	238	15	by	by	ADP
admet-169	238	16	preventing	prevent	VERB
admet-169	238	17	“	"	PUNCT
admet-169	238	18	chelation	chelation	NOUN
admet-169	238	19	”	"	PUNCT
admet-169	238	20	with	with	ADP
admet-169	238	21	the	the	DET
admet-169	238	22	magnesium	magnesium	NOUN
admet-169	238	23	or	or	CCONJ
admet-169	238	24	calcium	calcium	NOUN
admet-169	238	25	ions	ion	NOUN
admet-169	238	26	.	.	PUNCT
admet-169	239	1	this	this	PRON
admet-169	239	2	,	,	PUNCT
admet-169	239	3	in	in	ADP
admet-169	239	4	turn	turn	NOUN
admet-169	239	5	,	,	PUNCT
admet-169	239	6	yielded	yield	VERB
admet-169	239	7	more	more	ADV
admet-169	239	8	reproducible	reproducible	ADJ
admet-169	239	9	and	and	CCONJ
admet-169	239	10	accurate	accurate	ADJ
admet-169	239	11	permeability	permeability	NOUN
admet-169	239	12	characteristics	characteristic	NOUN
admet-169	239	13	.	.	PUNCT
admet-169	240	1	it	it	PRON
admet-169	240	2	should	should	AUX
admet-169	240	3	be	be	AUX
admet-169	240	4	noted	note	VERB
admet-169	240	5	that	that	SCONJ
admet-169	240	6	the	the	DET
admet-169	240	7	addition	addition	NOUN
admet-169	240	8	of	of	ADP
admet-169	240	9	transport	transport	NOUN
admet-169	240	10	inhibitors	inhibitor	NOUN
admet-169	240	11	to	to	ADP
admet-169	240	12	this	this	DET
admet-169	240	13	protocol	protocol	NOUN
admet-169	240	14	did	do	AUX
admet-169	240	15	not	not	PART
admet-169	240	16	affect	affect	VERB
admet-169	240	17	the	the	DET
admet-169	240	18	concentrations	concentration	NOUN
admet-169	240	19	of	of	ADP
admet-169	240	20	compounds	compound	NOUN
admet-169	240	21	in	in	ADP
admet-169	240	22	the	the	DET
admet-169	240	23	initial	initial	ADJ
admet-169	240	24	matrix	matrix	NOUN
admet-169	240	25	or	or	CCONJ
admet-169	240	26	after	after	ADP
admet-169	240	27	the	the	DET
admet-169	240	28	3	3	NUM
admet-169	240	29	hour	hour	NOUN
admet-169	240	30	experimental	experimental	ADJ
admet-169	240	31	time	time	NOUN
admet-169	240	32	.	.	PUNCT
admet-169	241	1	the	the	DET
admet-169	241	2	next	next	ADJ
admet-169	241	3	issue	issue	NOUN
admet-169	241	4	we	we	PRON
admet-169	241	5	observed	observe	VERB
admet-169	241	6	was	be	AUX
admet-169	241	7	due	due	ADJ
admet-169	241	8	to	to	ADP
admet-169	241	9	the	the	DET
admet-169	241	10	sampling	sampling	NOUN
admet-169	241	11	technique	technique	NOUN
admet-169	241	12	at	at	ADP
admet-169	241	13	individual	individual	ADJ
admet-169	241	14	time	time	NOUN
admet-169	241	15	points	point	NOUN
admet-169	241	16	whereby	whereby	SCONJ
admet-169	241	17	the	the	DET
admet-169	241	18	physical	physical	ADJ
admet-169	241	19	removal	removal	NOUN
admet-169	241	20	of	of	ADP
admet-169	241	21	too	too	ADV
admet-169	241	22	much	much	ADJ
admet-169	241	23	of	of	ADP
admet-169	241	24	the	the	DET
admet-169	241	25	receiver	receiver	ADJ
admet-169	241	26	compartments	compartment	NOUN
admet-169	241	27	medium	medium	ADV
admet-169	241	28	during	during	ADP
admet-169	241	29	the	the	DET
admet-169	241	30	experiment	experiment	NOUN
admet-169	241	31	led	lead	VERB
admet-169	241	32	to	to	ADP
admet-169	241	33	problems	problem	NOUN
admet-169	241	34	with	with	ADP
admet-169	241	35	the	the	DET
admet-169	241	36	monolayer	monolayer	NOUN
admet-169	241	37	where	where	SCONJ
admet-169	241	38	either	either	CCONJ
admet-169	241	39	a	a	DET
admet-169	241	40	rapid	rapid	ADJ
admet-169	241	41	increase	increase	NOUN
admet-169	241	42	or	or	CCONJ
admet-169	241	43	a	a	DET
admet-169	241	44	sharp	sharp	ADJ
admet-169	241	45	decline	decline	NOUN
admet-169	241	46	in	in	ADP
admet-169	241	47	accumulated	accumulate	VERB
admet-169	241	48	transport	transport	NOUN
admet-169	241	49	could	could	AUX
admet-169	241	50	be	be	AUX
admet-169	241	51	observed	observe	VERB
admet-169	241	52	on	on	ADP
admet-169	241	53	a	a	DET
admet-169	241	54	random	random	ADJ
admet-169	241	55	basis	basis	NOUN
admet-169	241	56	.	.	PUNCT
admet-169	242	1	the	the	DET
admet-169	242	2	monolayer	monolayer	NOUN
admet-169	242	3	could	could	AUX
admet-169	242	4	not	not	PART
admet-169	242	5	be	be	AUX
admet-169	242	6	observed	observe	VERB
admet-169	242	7	physically	physically	ADV
admet-169	242	8	but	but	CCONJ
admet-169	242	9	it	it	PRON
admet-169	242	10	was	be	AUX
admet-169	242	11	reasoned	reason	VERB
admet-169	242	12	that	that	SCONJ
admet-169	242	13	the	the	DET
admet-169	242	14	observed	observed	ADJ
admet-169	242	15	results	result	NOUN
admet-169	242	16	were	be	AUX
admet-169	242	17	due	due	ADJ
admet-169	242	18	to	to	ADP
admet-169	242	19	either	either	CCONJ
admet-169	242	20	stress	stress	NOUN
admet-169	242	21	breaks	break	NOUN
admet-169	242	22	or	or	CCONJ
admet-169	242	23	“	"	PUNCT
admet-169	242	24	bubbling	bubble	VERB
admet-169	242	25	effects	effect	NOUN
admet-169	242	26	”	"	PUNCT
admet-169	242	27	.	.	PUNCT
admet-169	243	1	the	the	DET
admet-169	243	2	bubbling	bubble	VERB
admet-169	243	3	effect	effect	NOUN
admet-169	243	4	was	be	AUX
admet-169	243	5	where	where	SCONJ
admet-169	243	6	air	air	NOUN
admet-169	243	7	bubbles	bubble	NOUN
admet-169	243	8	from	from	ADP
admet-169	243	9	sampling	sample	VERB
admet-169	243	10	procedures	procedure	NOUN
admet-169	243	11	had	have	AUX
admet-169	243	12	become	become	VERB
admet-169	243	13	trapped	trap	VERB
admet-169	243	14	under	under	ADP
admet-169	243	15	the	the	DET
admet-169	243	16	monolayer	monolayer	NOUN
admet-169	243	17	,	,	PUNCT
admet-169	243	18	isolating	isolate	VERB
admet-169	243	19	the	the	DET
admet-169	243	20	donor	donor	NOUN
admet-169	243	21	compartment	compartment	NOUN
admet-169	243	22	from	from	ADP
admet-169	243	23	the	the	DET
admet-169	243	24	receiver	receiver	ADJ
admet-169	243	25	compartment	compartment	NOUN
admet-169	243	26	.	.	PUNCT
admet-169	244	1	this	this	PRON
admet-169	244	2	had	have	VERB
admet-169	244	3	the	the	DET
admet-169	244	4	consequence	consequence	NOUN
admet-169	244	5	of	of	ADP
admet-169	244	6	having	have	VERB
admet-169	244	7	very	very	ADV
admet-169	244	8	high	high	ADJ
admet-169	244	9	variation	variation	NOUN
admet-169	244	10	between	between	ADP
admet-169	244	11	experimental	experimental	ADJ
admet-169	244	12	duplicates	duplicate	NOUN
admet-169	244	13	and	and	CCONJ
admet-169	244	14	inconsistent	inconsistent	ADJ
admet-169	244	15	results	result	NOUN
admet-169	244	16	on	on	ADP
admet-169	244	17	an	an	DET
admet-169	244	18	intra	intra	ADJ
admet-169	244	19	-	-	ADJ
admet-169	244	20	day	day	NOUN
admet-169	244	21	basis	basis	NOUN
admet-169	244	22	.	.	PUNCT
admet-169	245	1	lowering	lower	VERB
admet-169	245	2	the	the	DET
admet-169	245	3	volume	volume	NOUN
admet-169	245	4	sampled	sample	VERB
admet-169	245	5	and	and	CCONJ
admet-169	245	6	very	very	ADV
admet-169	245	7	careful	careful	ADJ
admet-169	245	8	mixing	mixing	NOUN
admet-169	245	9	of	of	ADP
admet-169	245	10	a	a	DET
admet-169	245	11	compartment	compartment	NOUN
admet-169	245	12	contents	content	NOUN
admet-169	245	13	reduced	reduce	VERB
admet-169	245	14	this	this	DET
admet-169	245	15	issue	issue	NOUN
admet-169	245	16	down	down	ADP
admet-169	245	17	to	to	ADP
admet-169	245	18	acceptable	acceptable	ADJ
admet-169	245	19	parameters	parameter	NOUN
admet-169	245	20	.	.	PUNCT
admet-169	246	1	however	however	ADV
admet-169	246	2	,	,	PUNCT
admet-169	246	3	sample	sample	NOUN
admet-169	246	4	volume	volume	NOUN
admet-169	246	5	was	be	AUX
admet-169	246	6	reduced	reduce	VERB
admet-169	246	7	from	from	ADP
admet-169	246	8	500	500	NUM
admet-169	246	9	µl	µl	NOUN
admet-169	246	10	to	to	ADP
admet-169	246	11	50	50	NUM
admet-169	246	12	µl	µl	NOUN
admet-169	246	13	,	,	PUNCT
admet-169	246	14	requiring	require	VERB
admet-169	246	15	the	the	DET
admet-169	246	16	adaptation	adaptation	NOUN
admet-169	246	17	of	of	ADP
admet-169	246	18	the	the	DET
admet-169	246	19	lcms	lcms	PROPN
admet-169	246	20	analytical	analytical	ADJ
admet-169	246	21	techniques	technique	NOUN
admet-169	246	22	to	to	PART
admet-169	246	23	be	be	AUX
admet-169	246	24	able	able	ADJ
admet-169	246	25	to	to	PART
admet-169	246	26	utilize	utilize	VERB
admet-169	246	27	only	only	ADV
admet-169	246	28	10	10	NUM
admet-169	246	29	-	-	SYM
admet-169	246	30	20	20	NUM
admet-169	246	31	µl	µl	NOUN
admet-169	246	32	of	of	ADP
admet-169	246	33	sample	sample	NOUN
admet-169	246	34	volume	volume	NOUN
admet-169	246	35	.	.	PUNCT
admet-169	247	1	for	for	ADP
admet-169	247	2	gefitinib	gefitinib	NOUN
admet-169	247	3	and	and	CCONJ
admet-169	247	4	erlotinib	erlotinib	NOUN
admet-169	247	5	this	this	PRON
admet-169	247	6	proved	prove	VERB
admet-169	247	7	to	to	PART
admet-169	247	8	be	be	AUX
admet-169	247	9	possible	possible	ADJ
admet-169	247	10	.	.	PUNCT
admet-169	248	1	with	with	ADP
admet-169	248	2	experimental	experimental	ADJ
admet-169	248	3	parameters	parameter	NOUN
admet-169	248	4	optimized	optimize	VERB
admet-169	248	5	a	a	DET
admet-169	248	6	further	further	ADJ
admet-169	248	7	problem	problem	NOUN
admet-169	248	8	was	be	AUX
admet-169	248	9	identified	identify	VERB
admet-169	248	10	in	in	ADP
admet-169	248	11	that	that	SCONJ
admet-169	248	12	the	the	DET
admet-169	248	13	monolayers	monolayer	NOUN
admet-169	248	14	did	do	AUX
admet-169	248	15	not	not	PART
admet-169	248	16	grow	grow	VERB
admet-169	248	17	consistently	consistently	ADV
admet-169	248	18	across	across	ADP
admet-169	248	19	the	the	DET
admet-169	248	20	24	24	NUM
admet-169	248	21	well	well	NOUN
admet-169	248	22	plates	plate	NOUN
admet-169	248	23	.	.	PUNCT
admet-169	249	1	wells	well	NOUN
admet-169	249	2	in	in	ADP
admet-169	249	3	the	the	DET
admet-169	249	4	centre	centre	NOUN
admet-169	249	5	portion	portion	NOUN
admet-169	249	6	of	of	ADP
admet-169	249	7	the	the	DET
admet-169	249	8	plate	plate	NOUN
admet-169	249	9	were	be	AUX
admet-169	249	10	observed	observe	VERB
admet-169	249	11	to	to	PART
admet-169	249	12	reach	reach	VERB
admet-169	249	13	starting	start	VERB
admet-169	249	14	experimental	experimental	ADJ
admet-169	249	15	conditions	condition	NOUN
admet-169	249	16	much	much	ADV
admet-169	249	17	slower	slow	ADJ
admet-169	249	18	than	than	ADP
admet-169	249	19	those	those	PRON
admet-169	249	20	located	locate	VERB
admet-169	249	21	on	on	ADP
admet-169	249	22	the	the	DET
admet-169	249	23	outer	outer	ADJ
admet-169	249	24	rim	rim	NOUN
admet-169	249	25	of	of	ADP
admet-169	249	26	the	the	DET
admet-169	249	27	plate	plate	NOUN
admet-169	249	28	.	.	PUNCT
admet-169	250	1	this	this	PRON
admet-169	250	2	created	create	VERB
admet-169	250	3	the	the	DET
admet-169	250	4	condition	condition	NOUN
admet-169	250	5	where	where	SCONJ
admet-169	250	6	centrally	centrally	ADV
admet-169	250	7	placed	place	VERB
admet-169	250	8	monolayers	monolayer	NOUN
admet-169	250	9	were	be	AUX
admet-169	250	10	just	just	ADV
admet-169	250	11	within	within	ADP
admet-169	250	12	specifications	specification	NOUN
admet-169	250	13	while	while	SCONJ
admet-169	250	14	outer	outer	ADJ
admet-169	250	15	monolayers	monolayer	NOUN
admet-169	250	16	were	be	AUX
admet-169	250	17	at	at	ADP
admet-169	250	18	the	the	DET
admet-169	250	19	maximum	maximum	ADJ
admet-169	250	20	limit	limit	NOUN
admet-169	250	21	.	.	PUNCT
admet-169	251	1	this	this	PRON
admet-169	251	2	created	create	VERB
admet-169	251	3	significant	significant	ADJ
admet-169	251	4	variation	variation	NOUN
admet-169	251	5	in	in	ADP
admet-169	251	6	the	the	DET
admet-169	251	7	observed	observe	VERB
admet-169	251	8	transport	transport	NOUN
admet-169	251	9	characteristics	characteristic	NOUN
admet-169	251	10	.	.	PUNCT
admet-169	252	1	this	this	DET
admet-169	252	2	issue	issue	NOUN
admet-169	252	3	was	be	AUX
admet-169	252	4	solved	solve	VERB
admet-169	252	5	by	by	ADP
admet-169	252	6	isolating	isolate	VERB
admet-169	252	7	each	each	DET
admet-169	252	8	well	well	NOUN
admet-169	252	9	with	with	ADP
admet-169	252	10	a	a	DET
admet-169	252	11	breathable	breathable	ADJ
admet-169	252	12	membrane	membrane	NOUN
admet-169	252	13	during	during	ADP
admet-169	252	14	the	the	DET
admet-169	252	15	entire	entire	ADJ
admet-169	252	16	growth	growth	NOUN
admet-169	252	17	and	and	CCONJ
admet-169	252	18	experimental	experimental	ADJ
admet-169	252	19	periods	period	NOUN
admet-169	252	20	.	.	PUNCT
admet-169	253	1	the	the	DET
admet-169	253	2	resulting	result	VERB
admet-169	253	3	protocol	protocol	NOUN
admet-169	253	4	was	be	AUX
admet-169	253	5	subsequently	subsequently	ADV
admet-169	253	6	used	use	VERB
admet-169	253	7	to	to	PART
admet-169	253	8	assess	assess	VERB
admet-169	253	9	transport	transport	NOUN
admet-169	253	10	characteristics	characteristic	NOUN
admet-169	253	11	of	of	ADP
admet-169	253	12	both	both	DET
admet-169	253	13	gefitinib	gefitinib	NOUN
admet-169	253	14	and	and	CCONJ
admet-169	253	15	erlotinib	erlotinib	NOUN
admet-169	253	16	.	.	PUNCT
admet-169	254	1	initial	initial	ADJ
admet-169	254	2	investigations	investigation	NOUN
admet-169	254	3	demonstrated	demonstrate	VERB
admet-169	254	4	significant	significant	ADJ
admet-169	254	5	differences	difference	NOUN
admet-169	254	6	in	in	ADP
admet-169	254	7	the	the	DET
admet-169	254	8	transport	transport	NOUN
admet-169	254	9	characteristics	characteristic	NOUN
admet-169	254	10	between	between	ADP
admet-169	254	11	gefitinib	gefitinib	NOUN
admet-169	254	12	and	and	CCONJ
admet-169	254	13	erlotinib	erlotinib	NOUN
admet-169	254	14	.	.	PUNCT
admet-169	255	1	gefitinib	gefitinib	NOUN
admet-169	255	2	demonstrated	demonstrate	VERB
admet-169	255	3	a	a	DET
admet-169	255	4	4	4	NUM
admet-169	255	5	fold	fold	ADV
admet-169	255	6	lower	low	ADJ
admet-169	255	7	uptake	uptake	ADJ
admet-169	255	8	compared	compare	VERB
admet-169	255	9	to	to	ADP
admet-169	255	10	erlotinib	erlotinib	NOUN
admet-169	255	11	when	when	SCONJ
admet-169	255	12	considering	consider	VERB
admet-169	255	13	the	the	DET
admet-169	255	14	transport	transport	NOUN
admet-169	255	15	in	in	ADP
admet-169	255	16	the	the	DET
admet-169	255	17	apical	apical	ADJ
admet-169	255	18	to	to	ADP
admet-169	255	19	basolateral	basolateral	ADJ
admet-169	255	20	direction	direction	NOUN
admet-169	255	21	.	.	PUNCT
admet-169	256	1	however	however	ADV
admet-169	256	2	,	,	PUNCT
admet-169	256	3	in	in	ADP
admet-169	256	4	the	the	DET
admet-169	256	5	reverse	reverse	ADJ
admet-169	256	6	direction	direction	NOUN
admet-169	256	7	erlotinib	erlotinib	NOUN
admet-169	256	8	demonstrated	demonstrate	VERB
admet-169	256	9	a	a	DET
admet-169	256	10	significantly	significantly	ADV
admet-169	256	11	higher	high	ADJ
admet-169	256	12	flow	flow	NOUN
admet-169	256	13	whereas	whereas	SCONJ
admet-169	256	14	for	for	ADP
admet-169	256	15	gefitinib	gefitinib	NOUN
admet-169	256	16	it	it	PRON
admet-169	256	17	was	be	AUX
admet-169	256	18	similar	similar	ADJ
admet-169	256	19	to	to	ADP
admet-169	256	20	the	the	DET
admet-169	256	21	apical	apical	ADJ
admet-169	256	22	to	to	ADP
admet-169	256	23	basolateral	basolateral	ADJ
admet-169	256	24	flow	flow	NOUN
admet-169	256	25	.	.	PUNCT
admet-169	257	1	the	the	DET
admet-169	257	2	high	high	ADJ
admet-169	257	3	flow	flow	NOUN
admet-169	257	4	of	of	ADP
admet-169	257	5	erlotinib	erlotinib	NOUN
admet-169	257	6	indicated	indicate	VERB
admet-169	257	7	a	a	DET
admet-169	257	8	potentially	potentially	ADV
admet-169	257	9	large	large	ADJ
admet-169	257	10	negative	negative	ADJ
admet-169	257	11	flow	flow	NOUN
admet-169	257	12	from	from	ADP
admet-169	257	13	the	the	DET
admet-169	257	14	system	system	NOUN
admet-169	257	15	which	which	PRON
admet-169	257	16	would	would	AUX
admet-169	257	17	lower	lower	VERB
admet-169	257	18	its	its	PRON
admet-169	257	19	overall	overall	ADJ
admet-169	257	20	bioavailability	bioavailability	NOUN
admet-169	257	21	.	.	PUNCT
admet-169	258	1	to	to	PART
admet-169	258	2	test	test	VERB
admet-169	258	3	the	the	DET
admet-169	258	4	applicability	applicability	NOUN
admet-169	258	5	of	of	ADP
admet-169	258	6	the	the	DET
admet-169	258	7	model	model	NOUN
admet-169	258	8	system	system	NOUN
admet-169	258	9	further	far	ADV
admet-169	258	10	two	two	NUM
admet-169	258	11	active	active	ADJ
admet-169	258	12	transport	transport	NOUN
admet-169	258	13	inhibitors	inhibitor	NOUN
admet-169	258	14	were	be	AUX
admet-169	258	15	used	use	VERB
admet-169	258	16	in	in	ADP
admet-169	258	17	combination	combination	NOUN
admet-169	258	18	with	with	ADP
admet-169	258	19	gefitinib	gefitinib	NOUN
admet-169	258	20	and	and	CCONJ
admet-169	258	21	erlotinib	erlotinib	NOUN
admet-169	258	22	.	.	PUNCT
admet-169	259	1	active	active	ADJ
admet-169	259	2	transport	transport	NOUN
admet-169	259	3	systems	system	NOUN
admet-169	259	4	dependent	dependent	ADJ
admet-169	259	5	on	on	ADP
admet-169	259	6	atp	atp	PROPN
admet-169	259	7	would	would	AUX
admet-169	259	8	have	have	AUX
admet-169	259	9	been	be	AUX
admet-169	259	10	blocked	block	VERB
admet-169	259	11	and	and	CCONJ
admet-169	259	12	any	any	DET
admet-169	259	13	difference	difference	NOUN
admet-169	259	14	in	in	ADP
admet-169	259	15	transport	transport	NOUN
admet-169	259	16	behaviour	behaviour	NOUN
admet-169	259	17	would	would	AUX
admet-169	259	18	indicate	indicate	VERB
admet-169	259	19	an	an	DET
admet-169	259	20	active	active	ADJ
admet-169	259	21	transport	transport	NOUN
admet-169	259	22	mechanism	mechanism	NOUN
admet-169	259	23	for	for	ADP
admet-169	259	24	these	these	DET
admet-169	259	25	compounds	compound	NOUN
admet-169	259	26	.	.	PUNCT
admet-169	260	1	the	the	DET
admet-169	260	2	admet	admet	PROPN
admet-169	260	3	&	&	CCONJ
admet-169	260	4	dmpk	dmpk	PROPN
admet-169	260	5	3(1	3(1	NUM
admet-169	260	6	)	)	PUNCT
admet-169	260	7	(	(	PUNCT
admet-169	260	8	2015	2015	NUM
admet-169	260	9	)	)	PUNCT
admet-169	260	10	51	51	NUM
admet-169	260	11	-	-	SYM
admet-169	260	12	67	67	NUM
admet-169	260	13	adaptation	adaptation	NOUN
admet-169	260	14	of	of	ADP
admet-169	260	15	human	human	ADJ
admet-169	260	16	gut	gut	NOUN
admet-169	260	17	epithelial	epithelial	ADJ
admet-169	260	18	model	model	NOUN
admet-169	260	19	doi	doi	NOUN
admet-169	260	20	:	:	PUNCT
admet-169	260	21	10.5599	10.5599	NUM
admet-169	260	22	/	/	SYM
admet-169	260	23	admet.3.1.169	admet.3.1.169	PROPN
admet-169	260	24	65	65	NUM
admet-169	260	25	compound	compound	NOUN
admet-169	260	26	sodium	sodium	NOUN
admet-169	260	27	azide	azide	NOUN
admet-169	260	28	inhibits	inhibit	VERB
admet-169	260	29	all	all	DET
admet-169	260	30	atp	atp	PROPN
admet-169	260	31	dependent	dependent	ADJ
admet-169	260	32	processes	process	NOUN
admet-169	260	33	[	[	X
admet-169	260	34	30	30	NUM
admet-169	260	35	]	]	PUNCT
admet-169	260	36	;	;	PUNCT
admet-169	260	37	therefore	therefore	ADV
admet-169	260	38	,	,	PUNCT
admet-169	260	39	if	if	SCONJ
admet-169	260	40	an	an	DET
admet-169	260	41	atp	atp	NOUN
admet-169	260	42	dependent	dependent	ADJ
admet-169	260	43	transporter	transporter	NOUN
admet-169	260	44	is	be	AUX
admet-169	260	45	involved	involve	VERB
admet-169	260	46	the	the	DET
admet-169	260	47	total	total	ADJ
admet-169	260	48	amount	amount	NOUN
admet-169	260	49	accumulated	accumulate	VERB
admet-169	260	50	would	would	AUX
admet-169	260	51	alter	alter	VERB
admet-169	260	52	depending	depend	VERB
admet-169	260	53	on	on	ADP
admet-169	260	54	which	which	DET
admet-169	260	55	membrane	membrane	NOUN
admet-169	260	56	it	it	PRON
admet-169	260	57	was	be	AUX
admet-169	260	58	located	locate	VERB
admet-169	260	59	on	on	ADP
admet-169	260	60	and	and	CCONJ
admet-169	260	61	the	the	DET
admet-169	260	62	direction	direction	NOUN
admet-169	260	63	of	of	ADP
admet-169	260	64	flow	flow	NOUN
admet-169	260	65	.	.	PUNCT
admet-169	261	1	this	this	DET
admet-169	261	2	model	model	NOUN
admet-169	261	3	system	system	NOUN
admet-169	261	4	demonstrated	demonstrate	VERB
admet-169	261	5	consistent	consistent	ADJ
admet-169	261	6	differences	difference	NOUN
admet-169	261	7	between	between	ADP
admet-169	261	8	control	control	NOUN
admet-169	261	9	and	and	CCONJ
admet-169	261	10	inhibited	inhibited	ADJ
admet-169	261	11	situations	situation	NOUN
admet-169	261	12	indicating	indicate	VERB
admet-169	261	13	that	that	SCONJ
admet-169	261	14	both	both	CCONJ
admet-169	261	15	multiple	multiple	ADJ
admet-169	261	16	active	active	ADJ
admet-169	261	17	and	and	CCONJ
admet-169	261	18	passive	passive	ADJ
admet-169	261	19	transport	transport	NOUN
admet-169	261	20	mechanisms	mechanism	NOUN
admet-169	261	21	are	be	AUX
admet-169	261	22	involved	involve	VERB
admet-169	261	23	in	in	ADP
admet-169	261	24	the	the	DET
admet-169	261	25	uptake	uptake	NOUN
admet-169	261	26	of	of	ADP
admet-169	261	27	both	both	DET
admet-169	261	28	these	these	DET
admet-169	261	29	compounds	compound	NOUN
admet-169	261	30	.	.	PUNCT
admet-169	262	1	these	these	DET
admet-169	262	2	results	result	NOUN
admet-169	262	3	also	also	ADV
admet-169	262	4	indicate	indicate	VERB
admet-169	262	5	that	that	SCONJ
admet-169	262	6	the	the	DET
admet-169	262	7	polarized	polarize	VERB
admet-169	262	8	membranes	membrane	NOUN
admet-169	262	9	of	of	ADP
admet-169	262	10	caco-2	caco-2	NUM
admet-169	262	11	cells	cell	NOUN
admet-169	262	12	had	have	VERB
admet-169	262	13	different	different	ADJ
admet-169	262	14	mechanisms	mechanism	NOUN
admet-169	262	15	for	for	ADP
admet-169	262	16	both	both	CCONJ
admet-169	262	17	uptake	uptake	ADJ
admet-169	262	18	and	and	CCONJ
admet-169	262	19	efflux	efflux	VERB
admet-169	262	20	which	which	PRON
admet-169	262	21	were	be	AUX
admet-169	262	22	different	different	ADJ
admet-169	262	23	for	for	ADP
admet-169	262	24	both	both	DET
admet-169	262	25	compounds	compound	NOUN
admet-169	262	26	.	.	PUNCT
admet-169	263	1	the	the	DET
admet-169	263	2	other	other	ADJ
admet-169	263	3	inhibitor	inhibitor	NOUN
admet-169	263	4	used	use	VERB
admet-169	263	5	was	be	AUX
admet-169	263	6	ko143	ko143	PROPN
admet-169	263	7	,	,	PUNCT
admet-169	263	8	a	a	DET
admet-169	263	9	more	more	ADV
admet-169	263	10	specific	specific	ADJ
admet-169	263	11	inhibitor	inhibitor	NOUN
admet-169	263	12	of	of	ADP
admet-169	263	13	abcg2	abcg2	NOUN
admet-169	263	14	only	only	ADV
admet-169	263	15	[	[	X
admet-169	263	16	31	31	NUM
admet-169	263	17	]	]	PUNCT
admet-169	263	18	.	.	PUNCT
admet-169	264	1	this	this	DET
admet-169	264	2	inhibitor	inhibitor	NOUN
admet-169	264	3	also	also	ADV
admet-169	264	4	showed	show	VERB
admet-169	264	5	differences	difference	NOUN
admet-169	264	6	for	for	ADP
admet-169	264	7	both	both	DET
admet-169	264	8	drugs	drug	NOUN
admet-169	264	9	and	and	CCONJ
admet-169	264	10	between	between	ADP
admet-169	264	11	apical	apical	ADJ
admet-169	264	12	or	or	CCONJ
admet-169	264	13	basolateral	basolateral	ADJ
admet-169	264	14	membranes	membrane	NOUN
admet-169	264	15	.	.	PUNCT
admet-169	265	1	for	for	ADP
admet-169	265	2	gefitinib	gefitinib	NOUN
admet-169	265	3	,	,	PUNCT
admet-169	265	4	the	the	DET
admet-169	265	5	presence	presence	NOUN
admet-169	265	6	of	of	ADP
admet-169	265	7	nan3	nan3	PROPN
admet-169	265	8	decreased	decrease	VERB
admet-169	265	9	the	the	DET
admet-169	265	10	observed	observe	VERB
admet-169	265	11	mass	mass	NOUN
admet-169	265	12	transport	transport	NOUN
admet-169	265	13	in	in	ADP
admet-169	265	14	the	the	DET
admet-169	265	15	apical	apical	ADJ
admet-169	265	16	to	to	ADP
admet-169	265	17	basolateral	basolateral	ADJ
admet-169	265	18	direction	direction	NOUN
admet-169	265	19	but	but	CCONJ
admet-169	265	20	not	not	PART
admet-169	265	21	completely	completely	ADV
admet-169	265	22	.	.	PUNCT
admet-169	266	1	this	this	PRON
admet-169	266	2	indicated	indicate	VERB
admet-169	266	3	that	that	SCONJ
admet-169	266	4	gefitinib	gefitinib	NOUN
admet-169	266	5	is	be	AUX
admet-169	266	6	apparently	apparently	ADV
admet-169	266	7	partially	partially	ADV
admet-169	266	8	transported	transport	VERB
admet-169	266	9	by	by	ADP
admet-169	266	10	both	both	CCONJ
admet-169	266	11	an	an	DET
admet-169	266	12	active	active	ADJ
admet-169	266	13	transport	transport	NOUN
admet-169	266	14	mechanism	mechanism	NOUN
admet-169	266	15	and	and	CCONJ
admet-169	266	16	partly	partly	ADV
admet-169	266	17	by	by	ADP
admet-169	266	18	passive	passive	ADJ
admet-169	266	19	diffusion	diffusion	NOUN
admet-169	267	1	[	[	X
admet-169	267	2	7	7	NUM
admet-169	267	3	]	]	PUNCT
admet-169	267	4	.	.	PUNCT
admet-169	268	1	inhibition	inhibition	NOUN
admet-169	268	2	of	of	ADP
admet-169	268	3	abcg2	abcg2	NOUN
admet-169	268	4	seemed	seem	VERB
admet-169	268	5	to	to	PART
admet-169	268	6	block	block	VERB
admet-169	268	7	the	the	DET
admet-169	268	8	drug	drug	NOUN
admet-169	268	9	from	from	ADP
admet-169	268	10	accumulating	accumulate	VERB
admet-169	268	11	within	within	ADP
admet-169	268	12	the	the	DET
admet-169	268	13	cell	cell	NOUN
admet-169	268	14	suggesting	suggest	VERB
admet-169	268	15	that	that	SCONJ
admet-169	268	16	abcg2	abcg2	NOUN
admet-169	268	17	might	might	AUX
admet-169	268	18	be	be	AUX
admet-169	268	19	one	one	NUM
admet-169	268	20	of	of	ADP
admet-169	268	21	several	several	ADJ
admet-169	268	22	transporters	transporter	NOUN
admet-169	268	23	involved	involve	VERB
admet-169	268	24	.	.	PUNCT
admet-169	269	1	however	however	ADV
admet-169	269	2	,	,	PUNCT
admet-169	269	3	nan3	nan3	PROPN
admet-169	269	4	inhibition	inhibition	NOUN
admet-169	269	5	in	in	ADP
admet-169	269	6	the	the	DET
admet-169	269	7	basolateral	basolateral	NOUN
admet-169	269	8	to	to	ADP
admet-169	269	9	apical	apical	ADJ
admet-169	269	10	direction	direction	NOUN
admet-169	269	11	increased	increase	VERB
admet-169	269	12	gefitinib	gefitinib	NOUN
admet-169	269	13	transported	transport	VERB
admet-169	269	14	whereas	whereas	SCONJ
admet-169	269	15	ko143	ko143	PROPN
admet-169	269	16	decreased	decrease	VERB
admet-169	269	17	the	the	DET
admet-169	269	18	total	total	NOUN
admet-169	269	19	suggesting	suggest	VERB
admet-169	269	20	the	the	DET
admet-169	269	21	role	role	NOUN
admet-169	269	22	of	of	ADP
admet-169	269	23	another	another	DET
admet-169	269	24	uncharacterized	uncharacterized	ADJ
admet-169	269	25	transporter	transporter	NOUN
admet-169	269	26	in	in	ADP
admet-169	269	27	addition	addition	NOUN
admet-169	269	28	to	to	ADP
admet-169	269	29	abcg2	abcg2	PROPN
admet-169	269	30	.	.	PUNCT
admet-169	270	1	investigation	investigation	NOUN
admet-169	270	2	into	into	ADP
admet-169	270	3	characteristics	characteristic	NOUN
admet-169	270	4	of	of	ADP
admet-169	270	5	erlotinib	erlotinib	NOUN
admet-169	270	6	demonstrated	demonstrate	VERB
admet-169	270	7	a	a	DET
admet-169	270	8	different	different	ADJ
admet-169	270	9	apical	apical	NOUN
admet-169	270	10	to	to	ADP
admet-169	270	11	basolateral	basolateral	ADJ
admet-169	270	12	pattern	pattern	NOUN
admet-169	270	13	.	.	PUNCT
admet-169	271	1	here	here	ADV
admet-169	271	2	nan3	nan3	PROPN
admet-169	271	3	increased	increase	VERB
admet-169	271	4	slightly	slightly	ADV
admet-169	271	5	the	the	DET
admet-169	271	6	amount	amount	NOUN
admet-169	271	7	transported	transport	VERB
admet-169	271	8	while	while	SCONJ
admet-169	271	9	ko143	ko143	PROPN
admet-169	271	10	decreased	decrease	VERB
admet-169	271	11	the	the	DET
admet-169	271	12	total	total	NOUN
admet-169	271	13	similar	similar	ADJ
admet-169	271	14	to	to	ADP
admet-169	271	15	gefitinib	gefitinib	NOUN
admet-169	271	16	in	in	ADP
admet-169	271	17	the	the	DET
admet-169	271	18	basolateral	basolateral	NOUN
admet-169	271	19	to	to	ADP
admet-169	271	20	apical	apical	ADJ
admet-169	271	21	directions	direction	NOUN
admet-169	271	22	.	.	PUNCT
admet-169	272	1	however	however	ADV
admet-169	272	2	,	,	PUNCT
admet-169	272	3	the	the	DET
admet-169	272	4	total	total	ADJ
admet-169	272	5	erlotinib	erlotinib	NOUN
admet-169	272	6	transported	transport	VERB
admet-169	272	7	was	be	AUX
admet-169	272	8	significantly	significantly	ADV
admet-169	272	9	higher	high	ADJ
admet-169	272	10	than	than	ADP
admet-169	272	11	gefitinib	gefitinib	NOUN
admet-169	272	12	despite	despite	SCONJ
admet-169	272	13	the	the	DET
admet-169	272	14	same	same	ADJ
admet-169	272	15	starting	starting	NOUN
admet-169	272	16	concentration	concentration	NOUN
admet-169	272	17	being	be	AUX
admet-169	272	18	used	use	VERB
admet-169	272	19	.	.	PUNCT
admet-169	273	1	for	for	ADP
admet-169	273	2	erlotinib	erlotinib	NOUN
admet-169	273	3	significantly	significantly	ADV
admet-169	273	4	lower	low	ADJ
admet-169	273	5	drug	drug	NOUN
admet-169	273	6	accumulation	accumulation	NOUN
admet-169	273	7	in	in	ADP
admet-169	273	8	the	the	DET
admet-169	273	9	cell	cell	NOUN
admet-169	273	10	was	be	AUX
admet-169	273	11	detected	detect	VERB
admet-169	273	12	suggesting	suggest	VERB
admet-169	273	13	that	that	SCONJ
admet-169	273	14	equilibrium	equilibrium	NOUN
admet-169	273	15	between	between	ADP
admet-169	273	16	donor	donor	NOUN
admet-169	273	17	and	and	CCONJ
admet-169	273	18	receiver	receiver	ADJ
admet-169	273	19	compartments	compartment	NOUN
admet-169	273	20	was	be	AUX
admet-169	273	21	the	the	DET
admet-169	273	22	driving	drive	VERB
admet-169	273	23	force	force	NOUN
admet-169	273	24	of	of	ADP
admet-169	273	25	this	this	DET
admet-169	273	26	mechanism	mechanism	NOUN
admet-169	273	27	with	with	ADP
admet-169	273	28	the	the	DET
admet-169	273	29	cellular	cellular	ADJ
admet-169	273	30	membrane	membrane	NOUN
admet-169	273	31	having	have	VERB
admet-169	273	32	little	little	ADJ
admet-169	273	33	resistance	resistance	NOUN
admet-169	273	34	to	to	ADP
admet-169	273	35	passive	passive	ADJ
admet-169	273	36	diffusion	diffusion	NOUN
admet-169	273	37	;	;	PUNCT
admet-169	273	38	it	it	PRON
admet-169	273	39	should	should	AUX
admet-169	273	40	be	be	AUX
admet-169	273	41	considered	consider	VERB
admet-169	273	42	whether	whether	SCONJ
admet-169	273	43	the	the	DET
admet-169	273	44	paracellular	paracellular	ADJ
admet-169	273	45	route	route	NOUN
admet-169	273	46	is	be	AUX
admet-169	273	47	possibly	possibly	ADV
admet-169	273	48	the	the	DET
admet-169	273	49	predominant	predominant	ADJ
admet-169	273	50	mechanisn	mechanisn	VERB
admet-169	273	51	involved	involve	VERB
admet-169	273	52	for	for	ADP
admet-169	273	53	this	this	DET
admet-169	273	54	compound	compound	NOUN
admet-169	273	55	.	.	PUNCT
admet-169	274	1	theoretically	theoretically	ADV
admet-169	274	2	passive	passive	ADJ
admet-169	274	3	diffusion	diffusion	NOUN
admet-169	274	4	results	result	NOUN
admet-169	274	5	in	in	ADP
admet-169	274	6	the	the	DET
admet-169	274	7	equilibrium	equilibrium	NOUN
admet-169	274	8	of	of	ADP
admet-169	274	9	the	the	DET
admet-169	274	10	compounds	compound	NOUN
admet-169	274	11	between	between	ADP
admet-169	274	12	donor	donor	NOUN
admet-169	274	13	,	,	PUNCT
admet-169	274	14	cellular	cellular	ADJ
admet-169	274	15	and	and	CCONJ
admet-169	274	16	receiver	receiver	ADJ
admet-169	274	17	compartments	compartment	NOUN
admet-169	274	18	[	[	X
admet-169	274	19	32	32	NUM
admet-169	274	20	]	]	PUNCT
admet-169	274	21	.	.	PUNCT
admet-169	275	1	however	however	ADV
admet-169	275	2	,	,	PUNCT
admet-169	275	3	for	for	ADP
admet-169	275	4	erlotinib	erlotinib	NOUN
admet-169	275	5	the	the	DET
admet-169	275	6	most	most	ADV
admet-169	275	7	significant	significant	ADJ
admet-169	275	8	of	of	ADP
admet-169	275	9	the	the	DET
admet-169	275	10	observed	observed	ADJ
admet-169	275	11	effects	effect	NOUN
admet-169	275	12	is	be	AUX
admet-169	275	13	that	that	SCONJ
admet-169	275	14	this	this	DET
admet-169	275	15	concentration	concentration	NOUN
admet-169	275	16	gradient	gradient	NOUN
admet-169	275	17	is	be	AUX
admet-169	275	18	higher	high	ADJ
admet-169	275	19	in	in	ADP
admet-169	275	20	the	the	DET
admet-169	275	21	basolateral	basolateral	NOUN
admet-169	275	22	(	(	PUNCT
admet-169	275	23	blood	blood	NOUN
admet-169	275	24	)	)	PUNCT
admet-169	275	25	to	to	ADP
admet-169	275	26	apical	apical	ADJ
admet-169	275	27	(	(	PUNCT
admet-169	275	28	gut	gut	NOUN
admet-169	275	29	)	)	PUNCT
admet-169	275	30	direction	direction	NOUN
admet-169	275	31	.	.	PUNCT
admet-169	276	1	this	this	PRON
admet-169	276	2	could	could	AUX
admet-169	276	3	have	have	VERB
admet-169	276	4	significant	significant	ADJ
admet-169	276	5	consequences	consequence	NOUN
admet-169	276	6	when	when	SCONJ
admet-169	276	7	considered	consider	VERB
admet-169	276	8	clinically	clinically	ADV
admet-169	276	9	;	;	PUNCT
admet-169	276	10	these	these	DET
admet-169	276	11	results	result	NOUN
admet-169	276	12	suggest	suggest	VERB
admet-169	276	13	that	that	SCONJ
admet-169	276	14	high	high	ADJ
admet-169	276	15	single	single	ADJ
admet-169	276	16	dose	dose	NOUN
admet-169	276	17	schedules	schedule	NOUN
admet-169	276	18	would	would	AUX
admet-169	276	19	have	have	VERB
admet-169	276	20	a	a	DET
admet-169	276	21	better	well	ADJ
admet-169	276	22	bioavailability	bioavailability	NOUN
admet-169	276	23	compared	compare	VERB
admet-169	276	24	to	to	ADP
admet-169	276	25	regular	regular	ADJ
admet-169	276	26	but	but	CCONJ
admet-169	276	27	lower	low	ADJ
admet-169	276	28	dosing	dosing	NOUN
admet-169	276	29	.	.	PUNCT
admet-169	277	1	in	in	ADP
admet-169	277	2	conclusion	conclusion	NOUN
admet-169	277	3	we	we	PRON
admet-169	277	4	validated	validate	VERB
admet-169	277	5	a	a	DET
admet-169	277	6	gut	gut	ADJ
admet-169	277	7	epithelial	epithelial	ADJ
admet-169	277	8	model	model	NOUN
admet-169	277	9	system	system	NOUN
admet-169	277	10	to	to	PART
admet-169	277	11	study	study	VERB
admet-169	277	12	the	the	DET
admet-169	277	13	potential	potential	ADJ
admet-169	277	14	gut	gut	NOUN
admet-169	277	15	uptake	uptake	ADJ
admet-169	277	16	mechanisms	mechanism	NOUN
admet-169	277	17	for	for	ADP
admet-169	277	18	two	two	NUM
admet-169	277	19	widely	widely	ADV
admet-169	277	20	used	use	VERB
admet-169	277	21	tkis	tkis	NOUN
admet-169	277	22	,	,	PUNCT
admet-169	277	23	erlotinib	erlotinib	NOUN
admet-169	277	24	and	and	CCONJ
admet-169	277	25	gefitinib	gefitinib	NOUN
admet-169	277	26	.	.	PUNCT
admet-169	278	1	the	the	DET
admet-169	278	2	caco-2	caco-2	NUM
admet-169	278	3	cell	cell	NOUN
admet-169	278	4	monolayer	monolayer	NOUN
admet-169	278	5	transwell	transwell	NOUN
admet-169	278	6	system	system	NOUN
admet-169	278	7	with	with	ADP
admet-169	278	8	a	a	DET
admet-169	278	9	3	3	NUM
admet-169	278	10	-	-	PUNCT
admet-169	278	11	day	day	NOUN
admet-169	278	12	culture	culture	NOUN
admet-169	278	13	system	system	NOUN
admet-169	278	14	proved	prove	VERB
admet-169	278	15	to	to	PART
admet-169	278	16	be	be	AUX
admet-169	278	17	very	very	ADV
admet-169	278	18	adaptable	adaptable	ADJ
admet-169	278	19	to	to	PART
admet-169	278	20	study	study	VERB
admet-169	278	21	drug	drug	NOUN
admet-169	278	22	transport	transport	NOUN
admet-169	278	23	and	and	CCONJ
admet-169	278	24	will	will	AUX
admet-169	278	25	be	be	AUX
admet-169	278	26	very	very	ADV
admet-169	278	27	useful	useful	ADJ
admet-169	278	28	to	to	ADP
admet-169	278	29	investigating	investigate	VERB
admet-169	278	30	the	the	DET
admet-169	278	31	role	role	NOUN
admet-169	278	32	of	of	ADP
admet-169	278	33	drug	drug	NOUN
admet-169	278	34	transporters	transporter	NOUN
admet-169	278	35	using	use	VERB
admet-169	278	36	a	a	DET
admet-169	278	37	blocker	blocker	NOUN
admet-169	278	38	like	like	ADP
admet-169	278	39	probenecid	probenecid	PROPN
admet-169	278	40	(	(	PUNCT
admet-169	278	41	blocker	blocker	NOUN
admet-169	278	42	of	of	ADP
admet-169	278	43	abcc	abcc	NOUN
admet-169	278	44	)	)	PUNCT
admet-169	278	45	and	and	CCONJ
admet-169	278	46	verapamil	verapamil	NOUN
admet-169	278	47	(	(	PUNCT
admet-169	278	48	blocker	blocker	NOUN
admet-169	278	49	of	of	ADP
admet-169	278	50	abcb1	abcb1	NOUN
admet-169	278	51	)	)	PUNCT
admet-169	278	52	,	,	PUNCT
admet-169	278	53	that	that	PRON
admet-169	278	54	would	would	AUX
admet-169	278	55	contribute	contribute	VERB
admet-169	278	56	important	important	ADJ
admet-169	278	57	overview	overview	NOUN
admet-169	278	58	of	of	ADP
admet-169	278	59	drug	drug	NOUN
admet-169	278	60	transporters	transporter	NOUN
admet-169	278	61	involved	involve	VERB
admet-169	278	62	in	in	ADP
admet-169	278	63	transport	transport	NOUN
admet-169	278	64	of	of	ADP
admet-169	278	65	tkis	tkis	PROPN
admet-169	278	66	.	.	PUNCT
admet-169	279	1	conclusions	conclusion	NOUN
admet-169	279	2	in	in	ADP
admet-169	279	3	conclusion	conclusion	NOUN
admet-169	279	4	we	we	PRON
admet-169	279	5	validated	validate	VERB
admet-169	279	6	a	a	DET
admet-169	279	7	gut	gut	ADJ
admet-169	279	8	epithelial	epithelial	ADJ
admet-169	279	9	model	model	NOUN
admet-169	279	10	system	system	NOUN
admet-169	279	11	to	to	PART
admet-169	279	12	study	study	VERB
admet-169	279	13	the	the	DET
admet-169	279	14	potential	potential	ADJ
admet-169	279	15	gut	gut	NOUN
admet-169	279	16	uptake	uptake	ADJ
admet-169	279	17	mechanisms	mechanism	NOUN
admet-169	279	18	for	for	ADP
admet-169	279	19	two	two	NUM
admet-169	279	20	widely	widely	ADV
admet-169	279	21	used	use	VERB
admet-169	279	22	tkis	tkis	NOUN
admet-169	279	23	,	,	PUNCT
admet-169	279	24	erlotinib	erlotinib	NOUN
admet-169	279	25	and	and	CCONJ
admet-169	279	26	gefitinib	gefitinib	NOUN
admet-169	279	27	.	.	PUNCT
admet-169	280	1	the	the	DET
admet-169	280	2	caco-2	caco-2	NUM
admet-169	280	3	cell	cell	NOUN
admet-169	280	4	monolayer	monolayer	NOUN
admet-169	280	5	transwell	transwell	NOUN
admet-169	280	6	system	system	NOUN
admet-169	280	7	with	with	ADP
admet-169	280	8	a	a	DET
admet-169	280	9	3	3	NUM
admet-169	280	10	-	-	PUNCT
admet-169	280	11	day	day	NOUN
admet-169	280	12	culture	culture	NOUN
admet-169	280	13	system	system	NOUN
admet-169	280	14	proved	prove	VERB
admet-169	280	15	to	to	PART
admet-169	280	16	be	be	AUX
admet-169	280	17	very	very	ADV
admet-169	280	18	adaptable	adaptable	ADJ
admet-169	280	19	to	to	PART
admet-169	280	20	study	study	VERB
admet-169	280	21	drug	drug	NOUN
admet-169	280	22	transport	transport	NOUN
admet-169	280	23	and	and	CCONJ
admet-169	280	24	will	will	AUX
admet-169	280	25	be	be	AUX
admet-169	280	26	very	very	ADV
admet-169	280	27	useful	useful	ADJ
admet-169	280	28	to	to	ADP
admet-169	280	29	investigating	investigate	VERB
admet-169	280	30	the	the	DET
admet-169	280	31	role	role	NOUN
admet-169	280	32	of	of	ADP
admet-169	280	33	drug	drug	NOUN
admet-169	280	34	transporters	transporter	NOUN
admet-169	280	35	using	use	VERB
admet-169	280	36	a	a	DET
admet-169	280	37	blocker	blocker	NOUN
admet-169	280	38	like	like	ADP
admet-169	280	39	probenecid	probenecid	PROPN
admet-169	280	40	(	(	PUNCT
admet-169	280	41	blocker	blocker	NOUN
admet-169	280	42	of	of	ADP
admet-169	280	43	peters	peters	PROPN
admet-169	280	44	et	et	PROPN
admet-169	280	45	al	al	PROPN
admet-169	280	46	.	.	PROPN
admet-169	280	47	admet	admet	PROPN
admet-169	280	48	&	&	CCONJ
admet-169	280	49	dmpk	dmpk	PROPN
admet-169	280	50	3(1	3(1	NUM
admet-169	280	51	)	)	PUNCT
admet-169	280	52	(	(	PUNCT
admet-169	280	53	2015	2015	NUM
admet-169	280	54	)	)	PUNCT
admet-169	280	55	51	51	NUM
admet-169	280	56	-	-	SYM
admet-169	280	57	67	67	NUM
admet-169	280	58	66	66	NUM
admet-169	280	59	abcc	abcc	NOUN
admet-169	280	60	)	)	PUNCT
admet-169	280	61	and	and	CCONJ
admet-169	280	62	verapamil	verapamil	NOUN
admet-169	280	63	(	(	PUNCT
admet-169	280	64	blocker	blocker	NOUN
admet-169	280	65	of	of	ADP
admet-169	280	66	abcb1	abcb1	NOUN
admet-169	280	67	)	)	PUNCT
admet-169	280	68	,	,	PUNCT
admet-169	280	69	that	that	PRON
admet-169	280	70	would	would	AUX
admet-169	280	71	contribute	contribute	VERB
admet-169	280	72	important	important	ADJ
admet-169	280	73	overview	overview	NOUN
admet-169	280	74	of	of	ADP
admet-169	280	75	drug	drug	NOUN
admet-169	280	76	transporters	transporter	NOUN
admet-169	280	77	involved	involve	VERB
admet-169	280	78	in	in	ADP
admet-169	280	79	transport	transport	NOUN
admet-169	280	80	of	of	ADP
admet-169	280	81	tkis	tkis	PROPN
admet-169	280	82	.	.	PUNCT
admet-169	281	1	references	reference	NOUN
admet-169	281	2	[	[	X
admet-169	281	3	1	1	X
admet-169	281	4	]	]	PUNCT
admet-169	281	5	e.	e.	PROPN
admet-169	281	6	k.	k.	PROPN
admet-169	281	7	rowinsky	rowinsky	PROPN
admet-169	281	8	,	,	PUNCT
admet-169	281	9	annu	annu	PROPN
admet-169	281	10	.	.	PUNCT
admet-169	281	11	rev	rev	AUX
admet-169	281	12	.	.	PROPN
admet-169	281	13	med	med	PROPN
admet-169	281	14	.	.	PUNCT
admet-169	282	1	55	55	NUM
admet-169	282	2	(	(	PUNCT
admet-169	282	3	2004	2004	NUM
admet-169	282	4	)	)	PUNCT
admet-169	282	5	433	433	NUM
admet-169	282	6	-	-	SYM
admet-169	282	7	457	457	NUM
admet-169	282	8	.	.	PUNCT
admet-169	283	1	[	[	X
admet-169	283	2	2	2	NUM
admet-169	283	3	]	]	PUNCT
admet-169	283	4	f.	f.	PROPN
admet-169	283	5	duffaud	duffaud	PROPN
admet-169	283	6	and	and	CCONJ
admet-169	283	7	c.	c.	PROPN
admet-169	283	8	a.	a.	PROPN
admet-169	283	9	le	le	PROPN
admet-169	283	10	cesne	cesne	PROPN
admet-169	283	11	,	,	PUNCT
admet-169	283	12	target	target	VERB
admet-169	283	13	oncol	oncol	ADJ
admet-169	283	14	.	.	PUNCT
admet-169	284	1	4	4	NUM
admet-169	284	2	(	(	PUNCT
admet-169	284	3	2009	2009	NUM
admet-169	284	4	)	)	PUNCT
admet-169	284	5	45	45	NUM
admet-169	284	6	-	-	SYM
admet-169	284	7	56	56	NUM
admet-169	284	8	[	[	X
admet-169	284	9	3	3	NUM
admet-169	284	10	]	]	X
admet-169	284	11	f.	f.	PROPN
admet-169	284	12	roszkiewicz	roszkiewicz	PROPN
admet-169	284	13	,	,	PUNCT
admet-169	284	14	r.	r.	PROPN
admet-169	284	15	garidi	garidi	PROPN
admet-169	284	16	,	,	PUNCT
admet-169	284	17	i.	i.	PROPN
admet-169	284	18	vaida	vaida	PROPN
admet-169	284	19	,	,	PUNCT
admet-169	284	20	b.	b.	PROPN
admet-169	284	21	royer	royer	PROPN
admet-169	284	22	,	,	PUNCT
admet-169	284	23	a.	a.	NOUN
admet-169	284	24	parcelier	parcelier	NOUN
admet-169	284	25	,	,	PUNCT
admet-169	284	26	j.	j.	PROPN
admet-169	284	27	p.	p.	PROPN
admet-169	284	28	marolleau	marolleau	PROPN
admet-169	284	29	,	,	PUNCT
admet-169	284	30	and	and	CCONJ
admet-169	284	31	g.	g.	PROPN
admet-169	284	32	damaj	damaj	PROPN
admet-169	284	33	,	,	PUNCT
admet-169	284	34	pharmacology	pharmacology	NOUN
admet-169	284	35	84	84	NUM
admet-169	284	36	(	(	PUNCT
admet-169	284	37	2009	2009	NUM
admet-169	284	38	)	)	PUNCT
admet-169	284	39	38	38	NUM
admet-169	284	40	-	-	SYM
admet-169	284	41	41	41	NUM
admet-169	284	42	.	.	PUNCT
admet-169	285	1	[	[	X
admet-169	285	2	4	4	NUM
admet-169	285	3	]	]	PUNCT
admet-169	285	4	m.	m.	NOUN
admet-169	285	5	tolomeo	tolomeo	NOUN
admet-169	285	6	,	,	PUNCT
admet-169	285	7	f.	f.	PROPN
admet-169	285	8	dieli	dieli	PROPN
admet-169	285	9	,	,	PUNCT
admet-169	285	10	n.	n.	PROPN
admet-169	285	11	gebbia	gebbia	PROPN
admet-169	285	12	,	,	PUNCT
admet-169	285	13	and	and	CCONJ
admet-169	285	14	d.	d.	PROPN
admet-169	285	15	simoni	simoni	PROPN
admet-169	285	16	,	,	PUNCT
admet-169	285	17	anticancer	anticancer	NOUN
admet-169	285	18	agents	agent	NOUN
admet-169	285	19	med	me	VERB
admet-169	285	20	.	.	PUNCT
admet-169	285	21	chem	chem	PROPN
admet-169	285	22	.	.	PUNCT
admet-169	286	1	9	9	NUM
admet-169	286	2	(	(	PUNCT
admet-169	286	3	2009	2009	NUM
admet-169	286	4	)	)	PUNCT
admet-169	286	5	853	853	NUM
admet-169	286	6	-	-	SYM
admet-169	286	7	863	863	NUM
admet-169	286	8	.	.	PUNCT
admet-169	287	1	[	[	X
admet-169	287	2	5	5	NUM
admet-169	287	3	]	]	PUNCT
admet-169	287	4	r.	r.	PROPN
admet-169	287	5	l.	l.	PROPN
admet-169	287	6	comis	comis	PROPN
admet-169	287	7	,	,	PUNCT
admet-169	287	8	oncologist	oncologist	NOUN
admet-169	287	9	.	.	PUNCT
admet-169	288	1	10	10	NUM
admet-169	288	2	(	(	PUNCT
admet-169	288	3	2005	2005	NUM
admet-169	288	4	)	)	PUNCT
admet-169	288	5	467	467	NUM
admet-169	288	6	-	-	SYM
admet-169	288	7	470	470	NUM
admet-169	288	8	.	.	PUNCT
admet-169	289	1	[	[	X
admet-169	289	2	6	6	NUM
admet-169	289	3	]	]	PUNCT
admet-169	289	4	n.	n.	PROPN
admet-169	289	5	p.	p.	PROPN
admet-169	290	1	van	van	PROPN
admet-169	290	2	erp	erp	PROPN
admet-169	290	3	,	,	PUNCT
admet-169	290	4	h.	h.	PROPN
admet-169	290	5	gelderblom	gelderblom	PROPN
admet-169	290	6	,	,	PUNCT
admet-169	290	7	and	and	CCONJ
admet-169	290	8	h.	h.	PROPN
admet-169	290	9	j.	j.	PROPN
admet-169	290	10	guchelaar	guchelaar	PROPN
admet-169	290	11	,	,	PUNCT
admet-169	290	12	cancer	cancer	NOUN
admet-169	290	13	treat	treat	NOUN
admet-169	290	14	.	.	PUNCT
admet-169	291	1	rev	rev	PROPN
admet-169	291	2	.	.	PROPN
admet-169	291	3	35	35	NUM
admet-169	291	4	(	(	PUNCT
admet-169	291	5	2009	2009	NUM
admet-169	291	6	)	)	PUNCT
admet-169	291	7	692706	692706	NUM
admet-169	291	8	.	.	PUNCT
admet-169	292	1	[	[	X
admet-169	292	2	7	7	X
admet-169	292	3	]	]	X
admet-169	292	4	m.	m.	NOUN
admet-169	292	5	galetti	galetti	PROPN
admet-169	292	6	,	,	PUNCT
admet-169	292	7	r.	r.	PROPN
admet-169	292	8	r.	r.	PROPN
admet-169	292	9	alfieri	alfieri	PROPN
admet-169	292	10	,	,	PUNCT
admet-169	292	11	a.	a.	NOUN
admet-169	292	12	cavazzoni	cavazzoni	NOUN
admet-169	292	13	,	,	PUNCT
admet-169	292	14	m.	m.	NOUN
admet-169	292	15	s.	s.	PROPN
admet-169	292	16	la	la	PROPN
admet-169	292	17	,	,	PUNCT
admet-169	292	18	m.	m.	NOUN
admet-169	292	19	bonelli	bonelli	PROPN
admet-169	292	20	,	,	PUNCT
admet-169	292	21	c.	c.	PROPN
admet-169	292	22	fumarola	fumarola	PROPN
admet-169	292	23	,	,	PUNCT
admet-169	292	24	p.	p.	PROPN
admet-169	292	25	mozzoni	mozzoni	PROPN
admet-169	292	26	,	,	PUNCT
admet-169	293	1	p.	p.	PROPN
admet-169	293	2	g.	g.	PROPN
admet-169	293	3	de	de	PROPN
admet-169	293	4	,	,	PUNCT
admet-169	293	5	r.	r.	PROPN
admet-169	293	6	andreoli	andreoli	PROPN
admet-169	293	7	,	,	PUNCT
admet-169	293	8	a.	a.	PROPN
admet-169	293	9	mutti	mutti	PROPN
admet-169	293	10	,	,	PUNCT
admet-169	293	11	m.	m.	NOUN
admet-169	293	12	mor	mor	PROPN
admet-169	293	13	,	,	PUNCT
admet-169	293	14	m.	m.	NOUN
admet-169	293	15	tiseo	tiseo	PROPN
admet-169	293	16	,	,	PUNCT
admet-169	293	17	a.	a.	NOUN
admet-169	293	18	ardizzoni	ardizzoni	NOUN
admet-169	293	19	,	,	PUNCT
admet-169	293	20	and	and	CCONJ
admet-169	293	21	p.	p.	PROPN
admet-169	293	22	g.	g.	PROPN
admet-169	293	23	petronini	petronini	PROPN
admet-169	293	24	,	,	PUNCT
admet-169	293	25	biochem	biochem	PROPN
admet-169	293	26	.	.	PUNCT
admet-169	294	1	pharmacol	pharmacol	PROPN
admet-169	294	2	.	.	PROPN
admet-169	295	1	80	80	NUM
admet-169	295	2	(	(	PUNCT
admet-169	295	3	2010	2010	NUM
admet-169	295	4	)	)	PUNCT
admet-169	295	5	179	179	NUM
admet-169	295	6	-	-	SYM
admet-169	295	7	187	187	NUM
admet-169	295	8	.	.	PUNCT
admet-169	296	1	[	[	X
admet-169	296	2	8	8	NUM
admet-169	296	3	]	]	X
admet-169	296	4	p.	p.	NOUN
admet-169	296	5	borst	borst	PROPN
admet-169	296	6	and	and	CCONJ
admet-169	296	7	r.	r.	PROPN
admet-169	296	8	o.	o.	PROPN
admet-169	296	9	elferink	elferink	PROPN
admet-169	296	10	,	,	PUNCT
admet-169	296	11	annu	annu	PROPN
admet-169	296	12	.	.	PUNCT
admet-169	296	13	rev	rev	PROPN
admet-169	296	14	.	.	PROPN
admet-169	296	15	biochem	biochem	PROPN
admet-169	296	16	.	.	PUNCT
admet-169	297	1	71	71	NUM
admet-169	297	2	(	(	PUNCT
admet-169	297	3	2002	2002	NUM
admet-169	297	4	)	)	PUNCT
admet-169	297	5	537	537	NUM
admet-169	297	6	-	-	SYM
admet-169	297	7	592	592	NUM
admet-169	297	8	.	.	PUNCT
admet-169	298	1	[	[	X
admet-169	298	2	9	9	NUM
admet-169	298	3	]	]	X
admet-169	298	4	c.	c.	PROPN
admet-169	298	5	lemos	lemos	PROPN
admet-169	298	6	,	,	PUNCT
admet-169	298	7	g.	g.	PROPN
admet-169	298	8	jansen	jansen	PROPN
admet-169	298	9	,	,	PUNCT
admet-169	298	10	and	and	CCONJ
admet-169	298	11	g.	g.	PROPN
admet-169	298	12	j.	j.	PROPN
admet-169	298	13	peters	peters	PROPN
admet-169	298	14	,	,	PUNCT
admet-169	298	15	br	br	PROPN
admet-169	298	16	.	.	PUNCT
admet-169	299	1	j.	j.	PROPN
admet-169	299	2	cancer	cancer	PROPN
admet-169	299	3	98	98	NUM
admet-169	299	4	(	(	PUNCT
admet-169	299	5	2008	2008	NUM
admet-169	299	6	)	)	PUNCT
admet-169	299	7	857	857	NUM
admet-169	299	8	-	-	SYM
admet-169	299	9	862	862	NUM
admet-169	299	10	.	.	PUNCT
admet-169	300	1	[	[	X
admet-169	300	2	10	10	NUM
admet-169	300	3	]	]	PUNCT
admet-169	300	4	m.	m.	NOUN
admet-169	300	5	m.	m.	NOUN
admet-169	300	6	gottesman	gottesman	NOUN
admet-169	300	7	,	,	PUNCT
admet-169	300	8	t.	t.	NOUN
admet-169	300	9	fojo	fojo	NOUN
admet-169	300	10	,	,	PUNCT
admet-169	300	11	and	and	CCONJ
admet-169	300	12	s.	s.	PROPN
admet-169	300	13	e.	e.	PROPN
admet-169	300	14	bates	bates	PROPN
admet-169	300	15	,	,	PUNCT
admet-169	300	16	nat	nat	PROPN
admet-169	300	17	.	.	PUNCT
admet-169	301	1	rev	rev	PROPN
admet-169	301	2	.	.	PUNCT
admet-169	302	1	cancer	cancer	NOUN
admet-169	302	2	2	2	NUM
admet-169	302	3	(	(	PUNCT
admet-169	302	4	2002	2002	NUM
admet-169	302	5	)	)	PUNCT
admet-169	302	6	48	48	NUM
admet-169	302	7	-	-	SYM
admet-169	302	8	58	58	NUM
admet-169	302	9	.	.	PUNCT
admet-169	303	1	[	[	X
admet-169	303	2	11	11	NUM
admet-169	303	3	]	]	PUNCT
admet-169	303	4	m.	m.	NOUN
admet-169	303	5	dean	dean	PROPN
admet-169	303	6	,	,	PUNCT
admet-169	303	7	a.	a.	NOUN
admet-169	303	8	rzhetsky	rzhetsky	NOUN
admet-169	303	9	,	,	PUNCT
admet-169	303	10	and	and	CCONJ
admet-169	303	11	r.	r.	NOUN
admet-169	303	12	allikmets	allikmet	NOUN
admet-169	303	13	,	,	PUNCT
admet-169	303	14	genome	genome	NOUN
admet-169	303	15	res	re	NOUN
admet-169	303	16	.	.	PUNCT
admet-169	303	17	11	11	NUM
admet-169	303	18	(	(	PUNCT
admet-169	303	19	2001	2001	NUM
admet-169	303	20	)	)	PUNCT
admet-169	303	21	1156	1156	NUM
admet-169	303	22	-	-	SYM
admet-169	303	23	1166	1166	NUM
admet-169	303	24	.	.	PUNCT
admet-169	304	1	[	[	X
admet-169	304	2	12	12	NUM
admet-169	304	3	]	]	PUNCT
admet-169	304	4	j.	j.	PROPN
admet-169	304	5	li	li	PROPN
admet-169	304	6	,	,	PUNCT
admet-169	304	7	g.	g.	PROPN
admet-169	304	8	cusatis	cusatis	PROPN
admet-169	304	9	,	,	PUNCT
admet-169	304	10	j.	j.	PROPN
admet-169	304	11	brahmer	brahmer	PROPN
admet-169	304	12	,	,	PUNCT
admet-169	304	13	a.	a.	NOUN
admet-169	304	14	sparreboom	sparreboom	PROPN
admet-169	304	15	,	,	PUNCT
admet-169	304	16	r.	r.	PROPN
admet-169	304	17	w.	w.	PROPN
admet-169	304	18	robey	robey	PROPN
admet-169	304	19	,	,	PUNCT
admet-169	304	20	s.	s.	PROPN
admet-169	304	21	e.	e.	PROPN
admet-169	304	22	bates	bates	PROPN
admet-169	304	23	,	,	PUNCT
admet-169	304	24	m.	m.	NOUN
admet-169	304	25	hidalgo	hidalgo	PROPN
admet-169	304	26	,	,	PUNCT
admet-169	304	27	and	and	CCONJ
admet-169	304	28	s.	s.	PROPN
admet-169	304	29	d.	d.	PROPN
admet-169	304	30	baker	baker	PROPN
admet-169	304	31	,	,	PUNCT
admet-169	304	32	cancer	cancer	NOUN
admet-169	304	33	biol	biol	PROPN
admet-169	304	34	.	.	PUNCT
admet-169	305	1	ther	ther	INTJ
admet-169	305	2	.	.	PUNCT
admet-169	306	1	6	6	NUM
admet-169	306	2	(	(	PUNCT
admet-169	306	3	2007	2007	NUM
admet-169	306	4	)	)	PUNCT
admet-169	306	5	432	432	NUM
admet-169	306	6	-	-	SYM
admet-169	306	7	438	438	NUM
admet-169	306	8	.	.	PUNCT
admet-169	307	1	[	[	X
admet-169	307	2	13	13	NUM
admet-169	307	3	]	]	PUNCT
admet-169	307	4	z.	z.	PROPN
admet-169	307	5	shi	shi	PROPN
admet-169	307	6	,	,	PUNCT
admet-169	307	7	x.	x.	PROPN
admet-169	307	8	x.	x.	PROPN
admet-169	307	9	peng	peng	PROPN
admet-169	307	10	,	,	PUNCT
admet-169	307	11	i.	i.	PROPN
admet-169	307	12	w.	w.	PROPN
admet-169	307	13	kim	kim	PROPN
admet-169	307	14	,	,	PUNCT
admet-169	307	15	s.	s.	PROPN
admet-169	307	16	shukla	shukla	PROPN
admet-169	307	17	,	,	PUNCT
admet-169	307	18	q.	q.	PROPN
admet-169	307	19	s.	s.	PROPN
admet-169	307	20	si	si	PROPN
admet-169	307	21	,	,	PUNCT
admet-169	307	22	r.	r.	PROPN
admet-169	307	23	w.	w.	PROPN
admet-169	307	24	robey	robey	PROPN
admet-169	307	25	,	,	PUNCT
admet-169	307	26	s.	s.	PROPN
admet-169	307	27	e.	e.	PROPN
admet-169	307	28	bates	bates	PROPN
admet-169	307	29	,	,	PUNCT
admet-169	307	30	t.	t.	PROPN
admet-169	307	31	shen	shen	PROPN
admet-169	307	32	,	,	PUNCT
admet-169	307	33	c.	c.	PROPN
admet-169	307	34	r.	r.	PROPN
admet-169	307	35	ashby	ashby	PROPN
admet-169	307	36	,	,	PUNCT
admet-169	307	37	jr	jr	PROPN
admet-169	307	38	.	.	PROPN
admet-169	307	39	,	,	PUNCT
admet-169	307	40	l.	l.	PROPN
admet-169	307	41	w.	w.	PROPN
admet-169	307	42	fu	fu	PROPN
admet-169	307	43	,	,	PUNCT
admet-169	307	44	s.	s.	PROPN
admet-169	307	45	v.	v.	PROPN
admet-169	307	46	ambudkar	ambudkar	PROPN
admet-169	307	47	,	,	PUNCT
admet-169	307	48	and	and	CCONJ
admet-169	307	49	z.	z.	PROPN
admet-169	307	50	s.	s.	PROPN
admet-169	307	51	chen	chen	PROPN
admet-169	307	52	,	,	PUNCT
admet-169	307	53	cancer	cancer	NOUN
admet-169	307	54	res	re	NOUN
admet-169	307	55	.	.	PUNCT
admet-169	308	1	67	67	NUM
admet-169	308	2	(	(	PUNCT
admet-169	308	3	2007	2007	NUM
admet-169	308	4	)	)	PUNCT
admet-169	308	5	1101211020	1101211020	NUM
admet-169	308	6	.	.	PUNCT
admet-169	309	1	[	[	X
admet-169	309	2	14	14	NUM
admet-169	309	3	]	]	PUNCT
admet-169	309	4	z.	z.	PROPN
admet-169	309	5	shi	shi	PROPN
admet-169	309	6	,	,	PUNCT
admet-169	309	7	s.	s.	PROPN
admet-169	309	8	parmar	parmar	PROPN
admet-169	309	9	,	,	PUNCT
admet-169	309	10	x.	x.	PROPN
admet-169	309	11	x.	x.	PROPN
admet-169	309	12	peng	peng	PROPN
admet-169	309	13	,	,	PUNCT
admet-169	309	14	t.	t.	PROPN
admet-169	309	15	shen	shen	PROPN
admet-169	309	16	,	,	PUNCT
admet-169	309	17	r.	r.	PROPN
admet-169	309	18	w.	w.	PROPN
admet-169	309	19	robey	robey	PROPN
admet-169	309	20	,	,	PUNCT
admet-169	309	21	s.	s.	PROPN
admet-169	309	22	e.	e.	PROPN
admet-169	309	23	bates	bates	PROPN
admet-169	309	24	,	,	PUNCT
admet-169	309	25	l.	l.	PROPN
admet-169	309	26	w.	w.	PROPN
admet-169	309	27	fu	fu	PROPN
admet-169	309	28	,	,	PUNCT
admet-169	309	29	y.	y.	PROPN
admet-169	309	30	shao	shao	PROPN
admet-169	309	31	,	,	PUNCT
admet-169	309	32	y.	y.	PROPN
admet-169	309	33	m.	m.	PROPN
admet-169	309	34	chen	chen	PROPN
admet-169	309	35	,	,	PUNCT
admet-169	309	36	f.	f.	PROPN
admet-169	309	37	zang	zang	PROPN
admet-169	309	38	,	,	PUNCT
admet-169	309	39	and	and	CCONJ
admet-169	309	40	z.	z.	PROPN
admet-169	309	41	s.	s.	PROPN
admet-169	309	42	chen	chen	PROPN
admet-169	309	43	,	,	PUNCT
admet-169	309	44	oncol	oncol	PROPN
admet-169	309	45	.	.	PUNCT
admet-169	309	46	rep	rep	PROPN
admet-169	309	47	.	.	PROPN
admet-169	309	48	21	21	NUM
admet-169	309	49	(	(	PUNCT
admet-169	309	50	2009	2009	NUM
admet-169	309	51	)	)	PUNCT
admet-169	309	52	483	483	NUM
admet-169	309	53	-	-	SYM
admet-169	309	54	489	489	NUM
admet-169	309	55	.	.	PUNCT
admet-169	310	1	[	[	X
admet-169	310	2	15	15	NUM
admet-169	310	3	]	]	X
admet-169	310	4	c.	c.	PROPN
admet-169	310	5	f.	f.	PROPN
admet-169	310	6	higgins	higgins	PROPN
admet-169	310	7	and	and	CCONJ
admet-169	310	8	m.	m.	NOUN
admet-169	310	9	m.	m.	NOUN
admet-169	310	10	gottesman	gottesman	PROPN
admet-169	310	11	,	,	PUNCT
admet-169	310	12	trends	trend	VERB
admet-169	310	13	biochem	biochem	PROPN
admet-169	310	14	.	.	PUNCT
admet-169	311	1	sci	sci	PROPN
admet-169	311	2	.	.	PROPN
admet-169	312	1	17	17	NUM
admet-169	312	2	(	(	PUNCT
admet-169	312	3	1992	1992	NUM
admet-169	312	4	)	)	PUNCT
admet-169	312	5	18	18	NUM
admet-169	312	6	-	-	SYM
admet-169	312	7	21	21	NUM
admet-169	312	8	.	.	PUNCT
admet-169	313	1	[	[	X
admet-169	313	2	16	16	NUM
admet-169	313	3	]	]	PUNCT
admet-169	313	4	p.	p.	PROPN
admet-169	313	5	stenberg	stenberg	PROPN
admet-169	313	6	,	,	PUNCT
admet-169	313	7	u.	u.	PROPN
admet-169	313	8	norinder	norinder	PROPN
admet-169	313	9	,	,	PUNCT
admet-169	313	10	k.	k.	PROPN
admet-169	313	11	luthman	luthman	PROPN
admet-169	313	12	,	,	PUNCT
admet-169	313	13	and	and	CCONJ
admet-169	313	14	p.	p.	PROPN
admet-169	313	15	artursson	artursson	PROPN
admet-169	313	16	,	,	PUNCT
admet-169	313	17	j.	j.	PROPN
admet-169	313	18	med	med	PROPN
admet-169	313	19	.	.	PROPN
admet-169	313	20	chem	chem	PROPN
admet-169	313	21	.	.	PUNCT
admet-169	314	1	44	44	NUM
admet-169	314	2	(	(	PUNCT
admet-169	314	3	2001	2001	NUM
admet-169	314	4	)	)	PUNCT
admet-169	314	5	1927	1927	NUM
admet-169	314	6	-	-	SYM
admet-169	314	7	1937	1937	NUM
admet-169	314	8	.	.	PUNCT
admet-169	315	1	[	[	X
admet-169	315	2	17	17	NUM
admet-169	315	3	]	]	X
admet-169	315	4	r.	r.	PROPN
admet-169	315	5	i.	i.	PROPN
admet-169	315	6	mahato	mahato	PROPN
admet-169	315	7	,	,	PUNCT
admet-169	315	8	a.	a.	PROPN
admet-169	315	9	s.	s.	PROPN
admet-169	315	10	narang	narang	PROPN
admet-169	315	11	,	,	PUNCT
admet-169	315	12	l.	l.	PROPN
admet-169	315	13	thoma	thoma	PROPN
admet-169	315	14	,	,	PUNCT
admet-169	315	15	and	and	CCONJ
admet-169	315	16	d.	d.	PROPN
admet-169	315	17	d.	d.	PROPN
admet-169	315	18	miller	miller	PROPN
admet-169	315	19	,	,	PUNCT
admet-169	315	20	crit	crit	PROPN
admet-169	315	21	rev	rev	PROPN
admet-169	315	22	.	.	PROPN
admet-169	316	1	ther	ther	PROPN
admet-169	316	2	.	.	PUNCT
admet-169	317	1	drug	drug	NOUN
admet-169	317	2	carrier	carrier	NOUN
admet-169	317	3	syst	syst	PROPN
admet-169	317	4	.	.	PROPN
admet-169	318	1	20	20	NUM
admet-169	318	2	(	(	PUNCT
admet-169	318	3	2003	2003	NUM
admet-169	318	4	)	)	PUNCT
admet-169	318	5	153	153	NUM
admet-169	318	6	-	-	SYM
admet-169	318	7	214	214	NUM
admet-169	318	8	.	.	PUNCT
admet-169	319	1	[	[	X
admet-169	319	2	18	18	NUM
admet-169	319	3	]	]	PUNCT
admet-169	319	4	a.	a.	NOUN
admet-169	319	5	t.	t.	PROPN
admet-169	319	6	heikkinen	heikkinen	PROPN
admet-169	319	7	,	,	PUNCT
admet-169	319	8	t.	t.	NOUN
admet-169	319	9	korjamo	korjamo	PROPN
admet-169	319	10	,	,	PUNCT
admet-169	319	11	and	and	CCONJ
admet-169	319	12	j.	j.	PROPN
admet-169	319	13	monkkonen	monkkonen	PROPN
admet-169	319	14	,	,	PUNCT
admet-169	319	15	basic	basic	ADJ
admet-169	319	16	clin	clin	PROPN
admet-169	319	17	.	.	PUNCT
admet-169	320	1	pharmacol	pharmacol	PROPN
admet-169	320	2	.	.	PUNCT
admet-169	321	1	toxicol	toxicol	PROPN
admet-169	321	2	.	.	PUNCT
admet-169	322	1	106	106	NUM
admet-169	322	2	(	(	PUNCT
admet-169	322	3	2010	2010	NUM
admet-169	322	4	)	)	PUNCT
admet-169	322	5	180	180	NUM
admet-169	322	6	-	-	SYM
admet-169	322	7	188	188	NUM
admet-169	322	8	.	.	PUNCT
admet-169	323	1	[	[	X
admet-169	323	2	19	19	NUM
admet-169	323	3	]	]	X
admet-169	323	4	j.	j.	PROPN
admet-169	323	5	fogh	fogh	PROPN
admet-169	323	6	and	and	CCONJ
admet-169	323	7	g.	g.	PROPN
admet-169	323	8	trempe	trempe	PROPN
admet-169	323	9	,	,	PUNCT
admet-169	323	10	new	new	ADJ
admet-169	323	11	human	human	ADJ
admet-169	323	12	tumor	tumor	NOUN
admet-169	323	13	cell	cell	NOUN
admet-169	323	14	lines	line	NOUN
admet-169	323	15	.	.	PUNCT
admet-169	324	1	in	in	ADP
admet-169	324	2	human	human	ADJ
admet-169	324	3	tumor	tumor	NOUN
admet-169	324	4	cells	cell	NOUN
admet-169	324	5	in	in	ADP
admet-169	324	6	vitro	vitro	X
admet-169	324	7	.	.	PUNCT
admet-169	325	1	j.fogh	j.fogh	PROPN
admet-169	325	2	,	,	PUNCT
admet-169	325	3	editor	editor	NOUN
admet-169	325	4	.	.	PUNCT
admet-169	325	5	,	,	PUNCT
admet-169	325	6	plenum	plenum	PROPN
admet-169	325	7	press	press	PROPN
admet-169	325	8	,	,	PUNCT
admet-169	325	9	new	new	PROPN
admet-169	325	10	york	york	PROPN
admet-169	325	11	,	,	PUNCT
admet-169	325	12	(	(	PUNCT
admet-169	325	13	1975	1975	NUM
admet-169	325	14	)	)	PUNCT
admet-169	325	15	115	115	NUM
admet-169	325	16	-	-	SYM
admet-169	325	17	159	159	NUM
admet-169	325	18	.	.	PUNCT
admet-169	326	1	[	[	X
admet-169	326	2	20	20	NUM
admet-169	326	3	]	]	PUNCT
admet-169	326	4	p.	p.	PROPN
admet-169	326	5	h.	h.	PROPN
admet-169	326	6	vachon	vachon	PROPN
admet-169	326	7	and	and	CCONJ
admet-169	326	8	j.	j.	PROPN
admet-169	326	9	f.	f.	PROPN
admet-169	326	10	beaulieu	beaulieu	PROPN
admet-169	326	11	,	,	PUNCT
admet-169	326	12	gastroenterology	gastroenterology	NOUN
admet-169	326	13	103	103	NUM
admet-169	326	14	(	(	PUNCT
admet-169	326	15	1992	1992	NUM
admet-169	326	16	)	)	PUNCT
admet-169	326	17	414	414	NUM
admet-169	326	18	-	-	SYM
admet-169	326	19	423	423	NUM
admet-169	326	20	.	.	PUNCT
admet-169	327	1	[	[	X
admet-169	327	2	21	21	NUM
admet-169	327	3	]	]	X
admet-169	327	4	p.	p.	NOUN
admet-169	327	5	shah	shah	PROPN
admet-169	327	6	,	,	PUNCT
admet-169	327	7	v.	v.	PROPN
admet-169	327	8	jogani	jogani	PROPN
admet-169	327	9	,	,	PUNCT
admet-169	327	10	t.	t.	PROPN
admet-169	327	11	bagchi	bagchi	NOUN
admet-169	327	12	,	,	PUNCT
admet-169	327	13	and	and	CCONJ
admet-169	327	14	a.	a.	NOUN
admet-169	327	15	misra	misra	PROPN
admet-169	327	16	,	,	PUNCT
admet-169	327	17	biotechnol	biotechnol	NOUN
admet-169	327	18	.	.	PUNCT
admet-169	328	1	prog	prog	NOUN
admet-169	328	2	.	.	PROPN
admet-169	329	1	22	22	NUM
admet-169	329	2	(	(	PUNCT
admet-169	329	3	2006	2006	NUM
admet-169	329	4	)	)	PUNCT
admet-169	329	5	186	186	NUM
admet-169	329	6	-	-	SYM
admet-169	329	7	198	198	NUM
admet-169	329	8	.	.	PUNCT
admet-169	330	1	[	[	X
admet-169	330	2	22	22	NUM
admet-169	330	3	]	]	X
admet-169	330	4	i.	i.	PROPN
admet-169	330	5	j.	j.	PROPN
admet-169	330	6	hidalgo	hidalgo	PROPN
admet-169	330	7	,	,	PUNCT
admet-169	330	8	t.	t.	PROPN
admet-169	330	9	j.	j.	PROPN
admet-169	330	10	raub	raub	PROPN
admet-169	330	11	,	,	PUNCT
admet-169	330	12	and	and	CCONJ
admet-169	330	13	r.	r.	PROPN
admet-169	330	14	t.	t.	PROPN
admet-169	330	15	borchardt	borchardt	ADJ
admet-169	330	16	,	,	PUNCT
admet-169	330	17	gastroenterology	gastroenterology	NOUN
admet-169	330	18	96	96	NUM
admet-169	330	19	(	(	PUNCT
admet-169	330	20	1989	1989	NUM
admet-169	330	21	)	)	PUNCT
admet-169	330	22	736	736	NUM
admet-169	330	23	-	-	SYM
admet-169	330	24	749	749	NUM
admet-169	330	25	.	.	PUNCT
admet-169	331	1	[	[	X
admet-169	331	2	23	23	NUM
admet-169	331	3	]	]	PUNCT
admet-169	331	4	i.	i.	PROPN
admet-169	331	5	hubatsch	hubatsch	PROPN
admet-169	331	6	,	,	PUNCT
admet-169	331	7	e.	e.	PROPN
admet-169	331	8	g.	g.	PROPN
admet-169	331	9	ragnarsson	ragnarsson	PROPN
admet-169	331	10	,	,	PUNCT
admet-169	331	11	and	and	CCONJ
admet-169	331	12	p.	p.	PROPN
admet-169	331	13	artursson	artursson	PROPN
admet-169	331	14	,	,	PUNCT
admet-169	331	15	nat	nat	PROPN
admet-169	331	16	.	.	PUNCT
admet-169	332	1	protoc	protoc	VERB
admet-169	332	2	.	.	PUNCT
admet-169	333	1	2	2	NUM
admet-169	333	2	(	(	PUNCT
admet-169	333	3	2007	2007	NUM
admet-169	333	4	)	)	PUNCT
admet-169	333	5	2111	2111	NUM
admet-169	333	6	-	-	SYM
admet-169	333	7	2119	2119	NUM
admet-169	333	8	.	.	PUNCT
admet-169	334	1	[	[	X
admet-169	334	2	24	24	NUM
admet-169	334	3	]	]	PUNCT
admet-169	334	4	s.	s.	PROPN
admet-169	334	5	yamashita	yamashita	PROPN
admet-169	334	6	,	,	PUNCT
admet-169	334	7	k.	k.	PROPN
admet-169	334	8	konishi	konishi	PROPN
admet-169	334	9	,	,	PUNCT
admet-169	334	10	y.	y.	PROPN
admet-169	334	11	yamazaki	yamazaki	PROPN
admet-169	334	12	,	,	PUNCT
admet-169	334	13	y.	y.	PROPN
admet-169	334	14	taki	taki	PROPN
admet-169	334	15	,	,	PUNCT
admet-169	334	16	t.	t.	PROPN
admet-169	334	17	sakane	sakane	PROPN
admet-169	334	18	,	,	PUNCT
admet-169	334	19	h.	h.	PROPN
admet-169	334	20	sezaki	sezaki	PROPN
admet-169	334	21	,	,	PUNCT
admet-169	334	22	and	and	CCONJ
admet-169	334	23	y.	y.	PROPN
admet-169	334	24	furuyama	furuyama	PROPN
admet-169	334	25	,	,	PUNCT
admet-169	334	26	j.	j.	PROPN
admet-169	334	27	pharm	pharm	PROPN
admet-169	334	28	.	.	PUNCT
admet-169	335	1	sci	sci	PROPN
admet-169	335	2	.	.	PROPN
admet-169	336	1	91	91	NUM
admet-169	336	2	(	(	PUNCT
admet-169	336	3	2002	2002	NUM
admet-169	336	4	)	)	PUNCT
admet-169	336	5	669	669	NUM
admet-169	336	6	-	-	SYM
admet-169	336	7	679	679	NUM
admet-169	336	8	.	.	PUNCT
admet-169	337	1	admet	admet	PROPN
admet-169	337	2	&	&	CCONJ
admet-169	337	3	dmpk	dmpk	PROPN
admet-169	337	4	3(1	3(1	NUM
admet-169	337	5	)	)	PUNCT
admet-169	337	6	(	(	PUNCT
admet-169	337	7	2015	2015	NUM
admet-169	337	8	)	)	PUNCT
admet-169	337	9	51	51	NUM
admet-169	337	10	-	-	SYM
admet-169	337	11	67	67	NUM
admet-169	337	12	adaptation	adaptation	NOUN
admet-169	337	13	of	of	ADP
admet-169	337	14	human	human	ADJ
admet-169	337	15	gut	gut	NOUN
admet-169	337	16	epithelial	epithelial	ADJ
admet-169	337	17	model	model	NOUN
admet-169	337	18	doi	doi	NOUN
admet-169	337	19	:	:	PUNCT
admet-169	337	20	10.5599	10.5599	NUM
admet-169	337	21	/	/	SYM
admet-169	337	22	admet.3.1.169	admet.3.1.169	ADP
admet-169	337	23	67	67	NUM
admet-169	338	1	[	[	X
admet-169	338	2	25	25	NUM
admet-169	338	3	]	]	PUNCT
admet-169	338	4	r.	r.	PROPN
admet-169	338	5	honeywell	honeywell	PROPN
admet-169	338	6	,	,	PUNCT
admet-169	338	7	k.	k.	PROPN
admet-169	338	8	yarzadah	yarzadah	PROPN
admet-169	338	9	,	,	PUNCT
admet-169	338	10	e.	e.	PROPN
admet-169	338	11	giovannetti	giovannetti	PROPN
admet-169	338	12	,	,	PUNCT
admet-169	338	13	n.	n.	NOUN
admet-169	338	14	losekoot	losekoot	NOUN
admet-169	338	15	,	,	PUNCT
admet-169	338	16	e.	e.	PROPN
admet-169	338	17	f.	f.	PROPN
admet-169	338	18	smit	smit	PROPN
admet-169	338	19	,	,	PUNCT
admet-169	338	20	m.	m.	NOUN
admet-169	338	21	walraven	walraven	PROPN
admet-169	338	22	,	,	PUNCT
admet-169	338	23	j.	j.	PROPN
admet-169	338	24	s.	s.	PROPN
admet-169	338	25	lind	lind	PROPN
admet-169	338	26	,	,	PUNCT
admet-169	338	27	c.	c.	PROPN
admet-169	338	28	tibaldi	tibaldi	PROPN
admet-169	338	29	,	,	PUNCT
admet-169	338	30	h.	h.	PROPN
admet-169	338	31	m.	m.	PROPN
admet-169	338	32	verheul	verheul	PROPN
admet-169	338	33	,	,	PUNCT
admet-169	338	34	and	and	CCONJ
admet-169	338	35	g.	g.	PROPN
admet-169	338	36	j.	j.	PROPN
admet-169	338	37	peters	peters	PROPN
admet-169	338	38	,	,	PUNCT
admet-169	338	39	j.	j.	PROPN
admet-169	338	40	chromatogr	chromatogr	PROPN
admet-169	338	41	.	.	PUNCT
admet-169	339	1	b	b	X
admet-169	339	2	analyt	analyt	ADJ
admet-169	339	3	.	.	PUNCT
admet-169	340	1	technol	technol	PROPN
admet-169	340	2	.	.	PROPN
admet-169	340	3	biomed	biome	VERB
admet-169	340	4	.	.	PUNCT
admet-169	341	1	life	life	PROPN
admet-169	341	2	sci	sci	PROPN
admet-169	341	3	.	.	PROPN
admet-169	342	1	878	878	NUM
admet-169	342	2	(	(	PUNCT
admet-169	342	3	2010	2010	NUM
admet-169	342	4	)	)	PUNCT
admet-169	342	5	1059	1059	NUM
admet-169	342	6	-	-	SYM
admet-169	342	7	1068	1068	NUM
admet-169	342	8	.	.	PUNCT
admet-169	343	1	[	[	X
admet-169	343	2	26	26	NUM
admet-169	343	3	]	]	PUNCT
admet-169	343	4	p.	p.	PROPN
admet-169	343	5	r.	r.	PROPN
admet-169	343	6	wielinga	wielinga	PROPN
admet-169	343	7	,	,	PUNCT
admet-169	343	8	e.	e.	PROPN
admet-169	343	9	de	de	PROPN
admet-169	343	10	waal	waal	PROPN
admet-169	343	11	,	,	PUNCT
admet-169	343	12	h.	h.	PROPN
admet-169	343	13	v.	v.	PROPN
admet-169	343	14	westerhoff	westerhoff	PROPN
admet-169	343	15	,	,	PUNCT
admet-169	343	16	and	and	CCONJ
admet-169	343	17	j.	j.	PROPN
admet-169	343	18	lankelma	lankelma	PROPN
admet-169	343	19	,	,	PUNCT
admet-169	343	20	j.	j.	PROPN
admet-169	343	21	pharm	pharm	PROPN
admet-169	343	22	.	.	PUNCT
admet-169	344	1	sci	sci	PROPN
admet-169	344	2	.	.	PROPN
admet-169	345	1	88	88	NUM
admet-169	345	2	(	(	PUNCT
admet-169	345	3	1999	1999	NUM
admet-169	345	4	)	)	PUNCT
admet-169	345	5	1340	1340	NUM
admet-169	345	6	-	-	SYM
admet-169	345	7	1347	1347	NUM
admet-169	345	8	.	.	PUNCT
admet-169	346	1	[	[	X
admet-169	346	2	27	27	NUM
admet-169	346	3	]	]	X
admet-169	346	4	f.	f.	PROPN
admet-169	346	5	broekman	broekman	PROPN
admet-169	346	6	,	,	PUNCT
admet-169	346	7	e.	e.	PROPN
admet-169	346	8	giovannetti	giovannetti	PROPN
admet-169	346	9	,	,	PUNCT
admet-169	346	10	and	and	CCONJ
admet-169	346	11	g.	g.	PROPN
admet-169	346	12	j.	j.	PROPN
admet-169	346	13	peters	peters	PROPN
admet-169	346	14	,	,	PUNCT
admet-169	346	15	world	world	NOUN
admet-169	346	16	j.	j.	PROPN
admet-169	346	17	clin	clin	PROPN
admet-169	346	18	.	.	PUNCT
admet-169	347	1	oncol	oncol	ADJ
admet-169	347	2	.	.	PUNCT
admet-169	348	1	2	2	NUM
admet-169	348	2	(	(	PUNCT
admet-169	348	3	2011	2011	NUM
admet-169	348	4	)	)	PUNCT
admet-169	348	5	80	80	NUM
admet-169	348	6	-	-	SYM
admet-169	348	7	93	93	NUM
admet-169	348	8	.	.	PUNCT
admet-169	349	1	[	[	X
admet-169	349	2	28	28	NUM
admet-169	349	3	]	]	X
admet-169	349	4	e.	e.	PROPN
admet-169	349	5	galvani	galvani	PROPN
admet-169	349	6	,	,	PUNCT
admet-169	349	7	r.	r.	PROPN
admet-169	349	8	alfieri	alfieri	PROPN
admet-169	349	9	,	,	PUNCT
admet-169	349	10	e.	e.	PROPN
admet-169	349	11	giovannetti	giovannetti	PROPN
admet-169	349	12	,	,	PUNCT
admet-169	349	13	a.	a.	NOUN
admet-169	349	14	cavazzoni	cavazzoni	NOUN
admet-169	349	15	,	,	PUNCT
admet-169	349	16	m.	m.	NOUN
admet-169	349	17	s.	s.	PROPN
admet-169	349	18	la	la	PROPN
admet-169	349	19	,	,	PUNCT
admet-169	349	20	m.	m.	NOUN
admet-169	349	21	galetti	galetti	PROPN
admet-169	349	22	,	,	PUNCT
admet-169	349	23	c.	c.	PROPN
admet-169	349	24	fumarola	fumarola	PROPN
admet-169	349	25	,	,	PUNCT
admet-169	349	26	m.	m.	NOUN
admet-169	349	27	bonelli	bonelli	PROPN
admet-169	349	28	,	,	PUNCT
admet-169	349	29	m.	m.	PROPN
admet-169	349	30	mor	mor	PROPN
admet-169	349	31	,	,	PUNCT
admet-169	349	32	m.	m.	NOUN
admet-169	349	33	tiseo	tiseo	PROPN
admet-169	349	34	,	,	PUNCT
admet-169	349	35	g.	g.	PROPN
admet-169	349	36	j.	j.	PROPN
admet-169	349	37	peters	peters	PROPN
admet-169	349	38	,	,	PUNCT
admet-169	349	39	p.	p.	PROPN
admet-169	349	40	g.	g.	PROPN
admet-169	349	41	petronini	petronini	PROPN
admet-169	349	42	,	,	PUNCT
admet-169	349	43	and	and	CCONJ
admet-169	349	44	a.	a.	NOUN
admet-169	349	45	ardizzoni	ardizzoni	PROPN
admet-169	349	46	,	,	PUNCT
admet-169	349	47	curr	curr	PROPN
admet-169	349	48	.	.	PUNCT
admet-169	349	49	pharm	pharm	PROPN
admet-169	349	50	.	.	PUNCT
admet-169	350	1	des	des	PROPN
admet-169	350	2	.	.	PROPN
admet-169	350	3	19	19	NUM
admet-169	350	4	(	(	PUNCT
admet-169	350	5	2013	2013	NUM
admet-169	350	6	)	)	PUNCT
admet-169	350	7	818	818	NUM
admet-169	350	8	-	-	SYM
admet-169	350	9	832	832	NUM
admet-169	350	10	.	.	PUNCT
admet-169	351	1	[	[	X
admet-169	351	2	29	29	NUM
admet-169	351	3	]	]	PUNCT
admet-169	351	4	s.	s.	PROPN
admet-169	351	5	yamashita	yamashita	PROPN
admet-169	351	6	,	,	PUNCT
admet-169	351	7	t.	t.	PROPN
admet-169	351	8	furubayashi	furubayashi	PROPN
admet-169	351	9	,	,	PUNCT
admet-169	351	10	m.	m.	NOUN
admet-169	351	11	kataoka	kataoka	PROPN
admet-169	351	12	,	,	PUNCT
admet-169	351	13	t.	t.	PROPN
admet-169	351	14	sakane	sakane	PROPN
admet-169	351	15	,	,	PUNCT
admet-169	351	16	h.	h.	PROPN
admet-169	351	17	sezaki	sezaki	PROPN
admet-169	351	18	,	,	PUNCT
admet-169	351	19	and	and	CCONJ
admet-169	351	20	h.	h.	PROPN
admet-169	351	21	tokuda	tokuda	PROPN
admet-169	351	22	,	,	PUNCT
admet-169	351	23	eur	eur	PROPN
admet-169	351	24	.	.	PUNCT
admet-169	351	25	j.	j.	PROPN
admet-169	351	26	pharm	pharm	PROPN
admet-169	351	27	.	.	PUNCT
admet-169	352	1	sci	sci	PROPN
admet-169	352	2	.	.	PROPN
admet-169	353	1	10	10	NUM
admet-169	353	2	(	(	PUNCT
admet-169	353	3	2000	2000	NUM
admet-169	353	4	)	)	PUNCT
admet-169	353	5	195	195	NUM
admet-169	353	6	-	-	SYM
admet-169	353	7	204	204	NUM
admet-169	353	8	.	.	PUNCT
admet-169	354	1	[	[	X
admet-169	354	2	30	30	NUM
admet-169	354	3	]	]	PUNCT
admet-169	354	4	j.	j.	PROPN
admet-169	354	5	h.	h.	PROPN
admet-169	354	6	hooijberg	hooijberg	PROPN
admet-169	354	7	,	,	PUNCT
admet-169	354	8	h.	h.	PROPN
admet-169	354	9	m.	m.	PROPN
admet-169	354	10	pinedo	pinedo	PROPN
admet-169	354	11	,	,	PUNCT
admet-169	354	12	c.	c.	PROPN
admet-169	354	13	vrasdonk	vrasdonk	PROPN
admet-169	354	14	,	,	PUNCT
admet-169	354	15	w.	w.	NOUN
admet-169	354	16	priebe	priebe	PROPN
admet-169	354	17	,	,	PUNCT
admet-169	354	18	j.	j.	PROPN
admet-169	354	19	lankelma	lankelma	PROPN
admet-169	354	20	,	,	PUNCT
admet-169	354	21	and	and	CCONJ
admet-169	354	22	h.	h.	PROPN
admet-169	354	23	j.	j.	PROPN
admet-169	354	24	broxterman	broxterman	PROPN
admet-169	354	25	,	,	PUNCT
admet-169	354	26	febs	febs	VERB
admet-169	354	27	lett	lett	PROPN
admet-169	354	28	.	.	PUNCT
admet-169	355	1	469	469	NUM
admet-169	355	2	(	(	PUNCT
admet-169	355	3	2000	2000	NUM
admet-169	355	4	)	)	PUNCT
admet-169	355	5	47	47	NUM
admet-169	355	6	-	-	SYM
admet-169	355	7	51	51	NUM
admet-169	355	8	.	.	PUNCT
admet-169	356	1	[	[	X
admet-169	356	2	31	31	NUM
admet-169	356	3	]	]	X
admet-169	356	4	c.	c.	PROPN
admet-169	356	5	lemos	lemos	PROPN
admet-169	356	6	,	,	PUNCT
admet-169	356	7	i.	i.	PROPN
admet-169	356	8	kathmann	kathmann	PROPN
admet-169	356	9	,	,	PUNCT
admet-169	356	10	e.	e.	PROPN
admet-169	356	11	giovannetti	giovannetti	PROPN
admet-169	356	12	,	,	PUNCT
admet-169	356	13	h.	h.	PROPN
admet-169	356	14	dekker	dekker	PROPN
admet-169	356	15	,	,	PUNCT
admet-169	356	16	g.	g.	PROPN
admet-169	356	17	l.	l.	PROPN
admet-169	356	18	scheffer	scheffer	PROPN
admet-169	356	19	,	,	PUNCT
admet-169	356	20	c.	c.	NOUN
admet-169	356	21	calhau	calhau	NOUN
admet-169	356	22	,	,	PUNCT
admet-169	356	23	g.	g.	PROPN
admet-169	356	24	jansen	jansen	PROPN
admet-169	356	25	,	,	PUNCT
admet-169	356	26	and	and	CCONJ
admet-169	356	27	g.	g.	PROPN
admet-169	356	28	j.	j.	PROPN
admet-169	356	29	peters	peters	PROPN
admet-169	356	30	,	,	PUNCT
admet-169	356	31	int	int	NOUN
admet-169	356	32	.	.	PUNCT
admet-169	357	1	j	j	PROPN
admet-169	357	2	cancer	cancer	NOUN
admet-169	357	3	123	123	NUM
admet-169	357	4	(	(	PUNCT
admet-169	357	5	2008	2008	NUM
admet-169	357	6	)	)	PUNCT
admet-169	357	7	1712	1712	NUM
admet-169	357	8	-	-	SYM
admet-169	357	9	1720	1720	NUM
admet-169	357	10	.	.	PUNCT
admet-169	358	1	[	[	X
admet-169	358	2	32	32	NUM
admet-169	358	3	]	]	PUNCT
admet-169	358	4	c.	c.	PROPN
admet-169	358	5	g.	g.	PROPN
admet-169	358	6	da	da	PROPN
admet-169	358	7	silva	silva	PROPN
admet-169	358	8	,	,	PUNCT
admet-169	358	9	r.	r.	PROPN
admet-169	358	10	j.	j.	PROPN
admet-169	358	11	honeywell	honeywell	PROPN
admet-169	358	12	,	,	PUNCT
admet-169	358	13	h.	h.	PROPN
admet-169	358	14	dekker	dekker	PROPN
admet-169	358	15	,	,	PUNCT
admet-169	358	16	and	and	CCONJ
admet-169	358	17	g.	g.	PROPN
admet-169	358	18	j.	j.	PROPN
admet-169	358	19	peters	peters	PROPN
admet-169	358	20	,	,	PUNCT
admet-169	358	21	expert	expert	NOUN
admet-169	358	22	.	.	PUNCT
admet-169	359	1	opin	opin	NOUN
admet-169	359	2	.	.	PUNCT
admet-169	360	1	drug	drug	NOUN
admet-169	360	2	metab	metab	PROPN
admet-169	360	3	toxicol	toxicol	NOUN
admet-169	360	4	.	.	PUNCT
admet-169	361	1	29	29	NUM
admet-169	361	2	(	(	PUNCT
admet-169	361	3	2015	2015	NUM
admet-169	361	4	)	)	PUNCT
admet-169	361	5	1	1	NUM
admet-169	361	6	-	-	SYM
admet-169	361	7	15	15	NUM
admet-169	361	8	.	.	PUNCT
admet-169	362	1	©	©	PROPN
admet-169	362	2	2015	2015	NUM
admet-169	362	3	by	by	ADP
admet-169	362	4	the	the	DET
admet-169	362	5	authors	author	NOUN
admet-169	362	6	;	;	PUNCT
admet-169	362	7	licensee	licensee	PROPN
admet-169	362	8	iapc	iapc	PROPN
admet-169	362	9	,	,	PUNCT
admet-169	362	10	zagreb	zagreb	PROPN
admet-169	362	11	,	,	PUNCT
admet-169	362	12	croatia	croatia	PROPN
admet-169	362	13	.	.	PUNCT
admet-169	363	1	this	this	DET
admet-169	363	2	article	article	NOUN
admet-169	363	3	is	be	AUX
admet-169	363	4	an	an	DET
admet-169	363	5	open	open	ADJ
admet-169	363	6	-	-	PUNCT
admet-169	363	7	access	access	NOUN
admet-169	363	8	article	article	NOUN
admet-169	363	9	distributed	distribute	VERB
admet-169	363	10	under	under	ADP
admet-169	363	11	the	the	DET
admet-169	363	12	terms	term	NOUN
admet-169	363	13	and	and	CCONJ
admet-169	363	14	conditions	condition	NOUN
admet-169	363	15	of	of	ADP
admet-169	363	16	the	the	DET
admet-169	363	17	creative	creative	ADJ
admet-169	363	18	commons	common	NOUN
admet-169	363	19	attribution	attribution	NOUN
admet-169	363	20	license	license	NOUN
admet-169	363	21	(	(	PUNCT
admet-169	363	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-169	363	23	)	)	PUNCT
admet-169	363	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN