id	sid	tid	token	lemma	pos
admet-182	1	1	manuscript	manuscript	PROPN
admet-182	1	2	doi	doi	PROPN
admet-182	1	3	:	:	PUNCT
admet-182	1	4	10.5599	10.5599	NUM
admet-182	1	5	/	/	SYM
admet-182	1	6	admet.3.2.182	admet.3.2.182	NOUN
admet-182	1	7	131	131	NUM
admet-182	1	8	admet	admet	PROPN
admet-182	1	9	&	&	CCONJ
admet-182	1	10	dmpk	dmpk	PROPN
admet-182	1	11	3(2	3(2	NUM
admet-182	1	12	)	)	PUNCT
admet-182	1	13	(	(	PUNCT
admet-182	1	14	2015	2015	NUM
admet-182	1	15	)	)	PUNCT
admet-182	1	16	131	131	NUM
admet-182	1	17	-	-	SYM
admet-182	1	18	140	140	NUM
admet-182	1	19	;	;	PUNCT
admet-182	1	20	doi	doi	NOUN
admet-182	1	21	:	:	PUNCT
admet-182	1	22	10.5599	10.5599	NUM
admet-182	1	23	/	/	SYM
admet-182	1	24	admet.3.2.182	admet.3.2.182	NOUN
admet-182	1	25	open	open	ADJ
admet-182	1	26	access	access	NOUN
admet-182	1	27	:	:	PUNCT
admet-182	1	28	issn	issn	PROPN
admet-182	1	29	:	:	PUNCT
admet-182	1	30	1848	1848	NUM
admet-182	1	31	-	-	SYM
admet-182	1	32	7718	7718	NUM
admet-182	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-182	1	34	original	original	ADJ
admet-182	1	35	scientific	scientific	ADJ
admet-182	1	36	article	article	NOUN
admet-182	1	37	pka	pka	NOUN
admet-182	1	38	-	-	PUNCT
admet-182	1	39	critical	critical	ADJ
admet-182	1	40	interpretations	interpretation	NOUN
admet-182	1	41	of	of	ADP
admet-182	1	42	solubility	solubility	NOUN
admet-182	1	43	–	–	PUNCT
admet-182	1	44	ph	ph	ADJ
admet-182	1	45	profiles	profile	NOUN
admet-182	1	46	:	:	PUNCT
admet-182	1	47	pg-300995	pg-300995	NOUN
admet-182	1	48	and	and	CCONJ
admet-182	1	49	nsc-639829	nsc-639829	NOUN
admet-182	1	50	case	case	NOUN
admet-182	1	51	studies	study	NOUN
admet-182	1	52	george	george	PROPN
admet-182	1	53	butcher,1	butcher,1	PROPN
admet-182	1	54	john	john	PROPN
admet-182	1	55	comer,1	comer,1	PROPN
admet-182	1	56	alex	alex	PROPN
admet-182	1	57	avdeef	avdeef	PROPN
admet-182	1	58	2	2	NUM
admet-182	1	59	,	,	PUNCT
admet-182	1	60	*	*	PROPN
admet-182	1	61	1	1	NUM
admet-182	1	62	sirius	sirius	PROPN
admet-182	1	63	analytical	analytical	PROPN
admet-182	1	64	ltd	ltd	PROPN
admet-182	1	65	.	.	PROPN
admet-182	1	66	,	,	PUNCT
admet-182	1	67	forest	forest	NOUN
admet-182	1	68	row	row	NOUN
admet-182	1	69	,	,	PUNCT
admet-182	1	70	west	west	PROPN
admet-182	1	71	sussex	sussex	NOUN
admet-182	1	72	rh18	rh18	PROPN
admet-182	1	73	5dw	5dw	PROPN
admet-182	1	74	,	,	PUNCT
admet-182	1	75	uk	uk	PROPN
admet-182	1	76	;	;	PUNCT
admet-182	1	77	2	2	NUM
admet-182	1	78	in	in	ADP
admet-182	1	79	-	-	PUNCT
admet-182	1	80	adme	adme	NOUN
admet-182	1	81	research	research	NOUN
admet-182	1	82	,	,	PUNCT
admet-182	1	83	1732	1732	NUM
admet-182	1	84	first	first	ADJ
admet-182	1	85	avenue	avenue	PROPN
admet-182	1	86	,	,	PUNCT
admet-182	1	87	#	#	SYM
admet-182	1	88	102	102	NUM
admet-182	1	89	,	,	PUNCT
admet-182	1	90	new	new	PROPN
admet-182	1	91	york	york	PROPN
admet-182	1	92	,	,	PUNCT
admet-182	1	93	ny	ny	PROPN
admet-182	1	94	10128	10128	NUM
admet-182	1	95	,	,	PUNCT
admet-182	1	96	usa	usa	PROPN
admet-182	1	97	.	.	PROPN
admet-182	2	1	*	*	PUNCT
admet-182	2	2	corresponding	correspond	VERB
admet-182	2	3	author	author	NOUN
admet-182	2	4	:	:	PUNCT
admet-182	2	5	e	e	NOUN
admet-182	2	6	-	-	NOUN
admet-182	2	7	mail	mail	NOUN
admet-182	2	8	:	:	PUNCT
admet-182	2	9	alex@in-adme.com	alex@in-adme.com	NOUN
admet-182	2	10	;	;	PUNCT
admet-182	2	11	tel	tel	PROPN
admet-182	2	12	.	.	PUNCT
admet-182	2	13	:	:	PUNCT
admet-182	3	1	+1	+1	PROPN
admet-182	3	2	647	647	NUM
admet-182	3	3	678	678	NUM
admet-182	3	4	5713	5713	NUM
admet-182	3	5	received	receive	VERB
admet-182	3	6	:	:	PUNCT
admet-182	3	7	april	april	PROPN
admet-182	3	8	07	07	NUM
admet-182	3	9	,	,	PUNCT
admet-182	3	10	2015	2015	NUM
admet-182	3	11	;	;	PUNCT
admet-182	3	12	revised	revise	VERB
admet-182	3	13	:	:	PUNCT
admet-182	3	14	june	june	PROPN
admet-182	3	15	19	19	NUM
admet-182	3	16	,	,	PUNCT
admet-182	3	17	2015	2015	NUM
admet-182	3	18	;	;	PUNCT
admet-182	3	19	published	publish	VERB
admet-182	3	20	:	:	PUNCT
admet-182	3	21	july	july	PROPN
admet-182	3	22	01	01	NUM
admet-182	3	23	,	,	PUNCT
admet-182	3	24	2015	2015	NUM
admet-182	3	25	abstract	abstract	ADJ
admet-182	3	26	two	two	NUM
admet-182	3	27	weak	weak	ADJ
admet-182	3	28	bases	basis	NOUN
admet-182	3	29	,	,	PUNCT
admet-182	3	30	pg-300995	pg-300995	PROPN
admet-182	3	31	(	(	PUNCT
admet-182	3	32	anti	anti	ADJ
admet-182	3	33	-	-	ADJ
admet-182	3	34	hiv	hiv	ADJ
admet-182	3	35	agent	agent	NOUN
admet-182	3	36	)	)	PUNCT
admet-182	3	37	and	and	CCONJ
admet-182	3	38	nsc-639829	nsc-639829	NOUN
admet-182	3	39	(	(	PUNCT
admet-182	3	40	anti	anti	ADJ
admet-182	3	41	-	-	ADJ
admet-182	3	42	tumor	tumor	ADJ
admet-182	3	43	agent	agent	NOUN
admet-182	3	44	)	)	PUNCT
admet-182	3	45	,	,	PUNCT
admet-182	3	46	whose	whose	DET
admet-182	3	47	log	log	NOUN
admet-182	3	48	s	s	PART
admet-182	3	49	–	–	PUNCT
admet-182	3	50	ph	ph	ADJ
admet-182	3	51	profiles	profile	NOUN
admet-182	3	52	had	have	AUX
admet-182	3	53	been	be	AUX
admet-182	3	54	previously	previously	ADV
admet-182	3	55	published	publish	VERB
admet-182	3	56	,	,	PUNCT
admet-182	3	57	but	but	CCONJ
admet-182	3	58	whose	whose	DET
admet-182	3	59	pka	pka	NOUN
admet-182	3	60	values	value	NOUN
admet-182	3	61	had	have	AUX
admet-182	3	62	not	not	PART
admet-182	3	63	been	be	AUX
admet-182	3	64	reported	report	VERB
admet-182	3	65	,	,	PUNCT
admet-182	3	66	were	be	AUX
admet-182	3	67	analyzed	analyze	VERB
admet-182	3	68	using	use	VERB
admet-182	3	69	a	a	DET
admet-182	3	70	method	method	NOUN
admet-182	3	71	which	which	PRON
admet-182	3	72	can	can	AUX
admet-182	3	73	determine	determine	VERB
admet-182	3	74	pka	pka	PROPN
admet-182	3	75	values	value	NOUN
admet-182	3	76	from	from	ADP
admet-182	3	77	log	log	PROPN
admet-182	3	78	s	s	PART
admet-182	3	79	–	–	PUNCT
admet-182	3	80	ph	ph	ADJ
admet-182	3	81	data	datum	NOUN
admet-182	3	82	.	.	PUNCT
admet-182	4	1	this	this	DET
admet-182	4	2	“	"	PUNCT
admet-182	4	3	sph	sph	PROPN
admet-182	4	4	-	-	PUNCT
admet-182	4	5	pka	pka	NOUN
admet-182	4	6	”	"	PUNCT
admet-182	4	7	technique	technique	NOUN
admet-182	4	8	,	,	PUNCT
admet-182	4	9	although	although	SCONJ
admet-182	4	10	often	often	ADV
admet-182	4	11	practiced	practice	VERB
admet-182	4	12	,	,	PUNCT
admet-182	4	13	can	can	AUX
admet-182	4	14	result	result	VERB
admet-182	4	15	in	in	ADP
admet-182	4	16	inaccurate	inaccurate	ADJ
admet-182	4	17	pka	pka	PROPN
admet-182	4	18	values	value	NOUN
admet-182	4	19	,	,	PUNCT
admet-182	4	20	for	for	ADP
admet-182	4	21	a	a	DET
admet-182	4	22	variety	variety	NOUN
admet-182	4	23	of	of	ADP
admet-182	4	24	reasons	reason	NOUN
admet-182	4	25	.	.	PUNCT
admet-182	5	1	the	the	DET
admet-182	5	2	operational	operational	ADJ
admet-182	5	3	sph	sph	PROPN
admet-182	5	4	-	-	PUNCT
admet-182	5	5	pka	pka	PROPN
admet-182	5	6	values	value	NOUN
admet-182	5	7	were	be	AUX
admet-182	5	8	compared	compare	VERB
admet-182	5	9	to	to	ADP
admet-182	5	10	those	those	PRON
admet-182	5	11	predicted	predict	VERB
admet-182	5	12	by	by	ADP
admet-182	5	13	marvinsketch	marvinsketch	PROPN
admet-182	5	14	(	(	PUNCT
admet-182	5	15	chemaxon	chemaxon	NOUN
admet-182	5	16	)	)	PUNCT
admet-182	5	17	,	,	PUNCT
admet-182	5	18	admet	admet	PROPN
admet-182	5	19	predictor	predictor	PROPN
admet-182	5	20	(	(	PUNCT
admet-182	5	21	simulation	simulation	NOUN
admet-182	5	22	plus	plus	CCONJ
admet-182	5	23	)	)	PUNCT
admet-182	5	24	,	,	PUNCT
admet-182	5	25	and	and	CCONJ
admet-182	5	26	acd	acd	NOUN
admet-182	5	27	/	/	SYM
admet-182	5	28	percepta	percepta	NOUN
admet-182	5	29	(	(	PUNCT
admet-182	5	30	acd	acd	NOUN
admet-182	5	31	/	/	SYM
admet-182	5	32	labs	lab	NOUN
admet-182	5	33	)	)	PUNCT
admet-182	5	34	.	.	PUNCT
admet-182	6	1	the	the	DET
admet-182	6	2	agreement	agreement	NOUN
admet-182	6	3	for	for	ADP
admet-182	6	4	the	the	DET
admet-182	6	5	sparingly	sparingly	ADV
admet-182	6	6	-	-	PUNCT
admet-182	6	7	soluble	soluble	ADJ
admet-182	6	8	pg-300995	pg-300995	NOUN
admet-182	6	9	was	be	AUX
admet-182	6	10	reasonably	reasonably	ADV
admet-182	6	11	good	good	ADJ
admet-182	6	12	.	.	PUNCT
admet-182	7	1	however	however	ADV
admet-182	7	2	,	,	PUNCT
admet-182	7	3	a	a	DET
admet-182	7	4	substantial	substantial	ADJ
admet-182	7	5	difference	difference	NOUN
admet-182	7	6	was	be	AUX
admet-182	7	7	found	find	VERB
admet-182	7	8	for	for	ADP
admet-182	7	9	the	the	DET
admet-182	7	10	practically	practically	ADV
admet-182	7	11	-	-	PUNCT
admet-182	7	12	insoluble	insoluble	ADJ
admet-182	7	13	nsc639829	nsc639829	NOUN
admet-182	7	14	.	.	PUNCT
admet-182	8	1	to	to	PART
admet-182	8	2	probe	probe	VERB
admet-182	8	3	this	this	PRON
admet-182	8	4	further	far	ADV
admet-182	8	5	,	,	PUNCT
admet-182	8	6	the	the	DET
admet-182	8	7	pka	pka	PROPN
admet-182	8	8	of	of	ADP
admet-182	8	9	nsc-639829	nsc-639829	NOUN
admet-182	8	10	was	be	AUX
admet-182	8	11	measured	measure	VERB
admet-182	8	12	by	by	ADP
admet-182	8	13	an	an	DET
admet-182	8	14	independent	independent	ADJ
admet-182	8	15	spectrophotometric	spectrophotometric	ADJ
admet-182	8	16	cosolvent	cosolvent	ADJ
admet-182	8	17	technique	technique	NOUN
admet-182	8	18	.	.	PUNCT
admet-182	9	1	the	the	DET
admet-182	9	2	log	log	NOUN
admet-182	9	3	s	s	NOUN
admet-182	9	4	ph	ph	NOUN
admet-182	9	5	profile	profile	NOUN
admet-182	9	6	of	of	ADP
admet-182	9	7	nsc-639829	nsc-639829	NOUN
admet-182	9	8	was	be	AUX
admet-182	9	9	then	then	ADV
admet-182	9	10	re	re	VERB
admet-182	9	11	-	-	VERB
admet-182	9	12	analyzed	analyze	VERB
admet-182	9	13	with	with	ADP
admet-182	9	14	the	the	DET
admet-182	9	15	independently	independently	ADV
admet-182	9	16	-	-	PUNCT
admet-182	9	17	measured	measure	VERB
admet-182	9	18	pka	pka	NOUN
admet-182	9	19	.	.	PUNCT
admet-182	10	1	it	it	PRON
admet-182	10	2	was	be	AUX
admet-182	10	3	found	find	VERB
admet-182	10	4	that	that	SCONJ
admet-182	10	5	the	the	DET
admet-182	10	6	equilibrium	equilibrium	NOUN
admet-182	10	7	model	model	NOUN
admet-182	10	8	which	which	PRON
admet-182	10	9	best	well	ADV
admet-182	10	10	fit	fit	VERB
admet-182	10	11	the	the	DET
admet-182	10	12	solubility	solubility	NOUN
admet-182	10	13	data	datum	NOUN
admet-182	10	14	is	be	AUX
admet-182	10	15	consistent	consistent	ADJ
admet-182	10	16	with	with	ADP
admet-182	10	17	the	the	DET
admet-182	10	18	presence	presence	NOUN
admet-182	10	19	of	of	ADP
admet-182	10	20	a	a	DET
admet-182	10	21	monocationic	monocationic	ADJ
admet-182	10	22	nsc-639829	nsc-639829	NOUN
admet-182	10	23	dimeric	dimeric	ADJ
admet-182	10	24	species	specie	NOUN
admet-182	10	25	below	below	ADP
admet-182	10	26	ph	ph	NOUN
admet-182	10	27	4	4	NUM
admet-182	10	28	.	.	PUNCT
admet-182	11	1	this	this	PRON
admet-182	11	2	illustrates	illustrate	VERB
admet-182	11	3	that	that	SCONJ
admet-182	11	4	an	an	DET
admet-182	11	5	independently	independently	ADV
admet-182	11	6	-	-	PUNCT
admet-182	11	7	determined	determine	VERB
admet-182	11	8	accurate	accurate	ADJ
admet-182	11	9	pka	pka	PROPN
admet-182	11	10	is	be	AUX
admet-182	11	11	critical	critical	ADJ
admet-182	11	12	to	to	ADP
admet-182	11	13	mechanistic	mechanistic	ADJ
admet-182	11	14	interpretations	interpretation	NOUN
admet-182	11	15	of	of	ADP
admet-182	11	16	solubility	solubility	NOUN
admet-182	11	17	-	-	PUNCT
admet-182	11	18	ph	ph	ADJ
admet-182	11	19	data	datum	NOUN
admet-182	11	20	.	.	PUNCT
admet-182	12	1	apparently	apparently	ADV
admet-182	12	2	,	,	PUNCT
admet-182	12	3	the	the	DET
admet-182	12	4	henderson	henderson	PROPN
admet-182	12	5	-	-	PUNCT
admet-182	12	6	hasselbalch	hasselbalch	PROPN
admet-182	12	7	equation	equation	NOUN
admet-182	12	8	holds	hold	VERB
admet-182	12	9	for	for	ADP
admet-182	12	10	pg300995	pg300995	PROPN
admet-182	12	11	,	,	PUNCT
admet-182	12	12	but	but	CCONJ
admet-182	12	13	not	not	PART
admet-182	12	14	nsc-639829	nsc-639829	NOUN
admet-182	12	15	.	.	PUNCT
admet-182	13	1	keywords	keyword	NOUN
admet-182	13	2	sparingly	sparingly	ADV
admet-182	13	3	-	-	PUNCT
admet-182	13	4	soluble	soluble	ADJ
admet-182	13	5	;	;	PUNCT
admet-182	13	6	solubility	solubility	NOUN
admet-182	13	7	as	as	ADP
admet-182	13	8	a	a	DET
admet-182	13	9	function	function	NOUN
admet-182	13	10	of	of	ADP
admet-182	13	11	ph	ph	NOUN
admet-182	13	12	;	;	PUNCT
admet-182	13	13	solubility	solubility	NOUN
admet-182	13	14	equations	equation	NOUN
admet-182	13	15	;	;	PUNCT
admet-182	13	16	shake	shake	NOUN
admet-182	13	17	-	-	PUNCT
admet-182	13	18	flask	flask	NOUN
admet-182	13	19	solubility	solubility	NOUN
admet-182	13	20	;	;	PUNCT
admet-182	13	21	aggregation	aggregation	NOUN
admet-182	13	22	introduction	introduction	NOUN
admet-182	13	23	it	it	PRON
admet-182	13	24	is	be	AUX
admet-182	13	25	possible	possible	ADJ
admet-182	13	26	to	to	PART
admet-182	13	27	determine	determine	VERB
admet-182	13	28	the	the	DET
admet-182	13	29	ionization	ionization	NOUN
admet-182	13	30	constant	constant	ADJ
admet-182	13	31	(	(	PUNCT
admet-182	13	32	pka	pka	NOUN
admet-182	13	33	)	)	PUNCT
admet-182	13	34	of	of	ADP
admet-182	13	35	an	an	DET
admet-182	13	36	ionizable	ionizable	ADJ
admet-182	13	37	molecule	molecule	NOUN
admet-182	13	38	from	from	ADP
admet-182	13	39	its	its	PRON
admet-182	13	40	solubilityph	solubilityph	ADJ
admet-182	13	41	profile	profile	NOUN
admet-182	13	42	(	(	PUNCT
admet-182	13	43	log	log	NOUN
admet-182	13	44	s	s	PART
admet-182	13	45	ph	ph	NOUN
admet-182	13	46	)	)	PUNCT
admet-182	13	47	,	,	PUNCT
admet-182	13	48	provided	provide	VERB
admet-182	13	49	the	the	DET
admet-182	13	50	curve	curve	NOUN
admet-182	13	51	is	be	AUX
admet-182	13	52	accurately	accurately	ADV
admet-182	13	53	predicted	predict	VERB
admet-182	13	54	by	by	ADP
admet-182	13	55	the	the	DET
admet-182	13	56	well	well	ADV
admet-182	13	57	-	-	PUNCT
admet-182	13	58	known	know	VERB
admet-182	13	59	hendersonhasselbalch	hendersonhasselbalch	NOUN
admet-182	13	60	equation	equation	NOUN
admet-182	13	61	[	[	X
admet-182	13	62	1	1	NUM
admet-182	13	63	]	]	PUNCT
admet-182	13	64	(	(	PUNCT
admet-182	13	65	cf	cf	NOUN
admet-182	13	66	.	.	NOUN
admet-182	13	67	,	,	PUNCT
admet-182	13	68	appendix	appendix	NOUN
admet-182	13	69	)	)	PUNCT
admet-182	13	70	.	.	PUNCT
admet-182	14	1	this	this	DET
admet-182	14	2	simple	simple	ADJ
admet-182	14	3	pka	pka	PROPN
admet-182	14	4	-	-	PUNCT
admet-182	14	5	from	from	ADP
admet-182	14	6	-	-	PUNCT
admet-182	14	7	solubility	solubility	NOUN
admet-182	14	8	(	(	PUNCT
admet-182	14	9	sph	sph	NOUN
admet-182	14	10	-	-	PUNCT
admet-182	14	11	pka	pka	PROPN
admet-182	14	12	)	)	PUNCT
admet-182	14	13	method	method	NOUN
admet-182	14	14	has	have	AUX
admet-182	14	15	been	be	AUX
admet-182	14	16	popularized	popularize	VERB
admet-182	14	17	by	by	ADP
admet-182	14	18	zimmermann	zimmermann	PROPN
admet-182	14	19	[	[	X
admet-182	14	20	2	2	NUM
admet-182	14	21	]	]	PUNCT
admet-182	14	22	,	,	PUNCT
admet-182	14	23	and	and	CCONJ
admet-182	14	24	has	have	AUX
admet-182	14	25	been	be	AUX
admet-182	14	26	practiced	practice	VERB
admet-182	14	27	often	often	ADV
admet-182	14	28	,	,	PUNCT
admet-182	14	29	as	as	SCONJ
admet-182	14	30	noted	note	VERB
admet-182	14	31	in	in	ADP
admet-182	14	32	the	the	DET
admet-182	14	33	critical	critical	ADJ
admet-182	14	34	pka	pka	PROPN
admet-182	14	35	compilations	compilation	NOUN
admet-182	14	36	by	by	ADP
admet-182	14	37	prankerd	prankerd	NOUN
admet-182	15	1	[	[	X
admet-182	15	2	3	3	NUM
admet-182	15	3	]	]	PUNCT
admet-182	15	4	.	.	PUNCT
admet-182	16	1	however	however	ADV
admet-182	16	2	,	,	PUNCT
admet-182	16	3	the	the	DET
admet-182	16	4	sph	sph	PROPN
admet-182	16	5	-	-	PUNCT
admet-182	16	6	pka	pka	PROPN
admet-182	16	7	method	method	NOUN
admet-182	16	8	can	can	AUX
admet-182	16	9	be	be	AUX
admet-182	16	10	significantly	significantly	ADV
admet-182	16	11	inaccurate	inaccurate	ADJ
admet-182	16	12	when	when	SCONJ
admet-182	16	13	sample	sample	NOUN
admet-182	16	14	molecules	molecule	NOUN
admet-182	16	15	in	in	ADP
admet-182	16	16	saturated	saturate	VERB
admet-182	16	17	solutions	solution	NOUN
admet-182	16	18	react	react	VERB
admet-182	16	19	with	with	ADP
admet-182	16	20	buffer	buffer	NOUN
admet-182	16	21	components	component	NOUN
admet-182	16	22	to	to	PART
admet-182	16	23	form	form	VERB
admet-182	16	24	water	water	NOUN
admet-182	16	25	-	-	PUNCT
admet-182	16	26	soluble	soluble	ADJ
admet-182	16	27	complexes	complex	NOUN
admet-182	16	28	,	,	PUNCT
admet-182	16	29	or	or	CCONJ
admet-182	16	30	with	with	ADP
admet-182	16	31	each	each	DET
admet-182	16	32	other	other	ADJ
admet-182	16	33	to	to	PART
admet-182	16	34	form	form	VERB
admet-182	16	35	water	water	NOUN
admet-182	16	36	-	-	PUNCT
admet-182	16	37	soluble	soluble	ADJ
admet-182	16	38	aggregates	aggregate	NOUN
admet-182	16	39	/	/	SYM
admet-182	16	40	oligomers	oligomer	NOUN
admet-182	16	41	(	(	PUNCT
admet-182	16	42	dimers	dimer	NOUN
admet-182	16	43	,	,	PUNCT
admet-182	16	44	trimers	trimer	NOUN
admet-182	16	45	,	,	PUNCT
admet-182	16	46	…	…	PUNCT
admet-182	17	1	[	[	X
admet-182	17	2	4	4	NUM
admet-182	17	3	]	]	PUNCT
admet-182	17	4	)	)	PUNCT
admet-182	17	5	or	or	CCONJ
admet-182	17	6	micelles	micelle	NOUN
admet-182	17	7	with	with	ADP
admet-182	17	8	large	large	ADJ
admet-182	17	9	aggregation	aggregation	NOUN
admet-182	17	10	numbers	number	NOUN
admet-182	17	11	[	[	X
admet-182	17	12	5	5	NUM
admet-182	17	13	]	]	PUNCT
admet-182	17	14	.	.	PUNCT
admet-182	18	1	ionizable	ionizable	ADJ
admet-182	18	2	molecules	molecule	NOUN
admet-182	18	3	that	that	PRON
admet-182	18	4	are	be	AUX
admet-182	18	5	surface	surface	NOUN
admet-182	18	6	-	-	PUNCT
admet-182	18	7	active	active	ADJ
admet-182	18	8	(	(	PUNCT
admet-182	18	9	e.g.	e.g.	ADJ
admet-182	18	10	,	,	PUNCT
admet-182	18	11	long	long	ADJ
admet-182	18	12	-	-	PUNCT
admet-182	18	13	chain	chain	NOUN
admet-182	18	14	acylcarnitines	acylcarnitine	NOUN
admet-182	18	15	[	[	X
admet-182	18	16	5	5	NUM
admet-182	18	17	]	]	PUNCT
admet-182	18	18	,	,	PUNCT
admet-182	18	19	prostaglandins	prostaglandin	NOUN
admet-182	18	20	[	[	PUNCT
admet-182	18	21	6	6	NUM
admet-182	18	22	]	]	PUNCT
admet-182	18	23	)	)	PUNCT
admet-182	18	24	or	or	CCONJ
admet-182	18	25	that	that	PRON
admet-182	18	26	have	have	VERB
admet-182	18	27	strong	strong	ADJ
admet-182	18	28	acid	acid	NOUN
admet-182	18	29	-	-	PUNCT
admet-182	18	30	base	base	NOUN
admet-182	18	31	hydrogen	hydrogen	NOUN
admet-182	18	32	potentials	potential	NOUN
admet-182	18	33	(	(	PUNCT
admet-182	18	34	e.g.	e.g.	ADV
admet-182	18	35	,	,	PUNCT
admet-182	18	36	oxytetracycline	oxytetracycline	ADJ
admet-182	18	37	[	[	X
admet-182	18	38	7	7	NUM
admet-182	18	39	]	]	PUNCT
admet-182	18	40	,	,	PUNCT
admet-182	18	41	cefadroxyl	cefadroxyl	PROPN
admet-182	19	1	[	[	X
admet-182	19	2	8	8	NUM
admet-182	19	3	]	]	PUNCT
admet-182	19	4	)	)	PUNCT
admet-182	19	5	have	have	VERB
admet-182	19	6	a	a	DET
admet-182	19	7	tendency	tendency	NOUN
admet-182	19	8	to	to	PART
admet-182	19	9	form	form	VERB
admet-182	19	10	self	self	NOUN
admet-182	19	11	-	-	PUNCT
admet-182	19	12	aggregates	aggregate	NOUN
admet-182	19	13	and/or	and/or	CCONJ
admet-182	19	14	micelles	micelle	NOUN
admet-182	19	15	in	in	ADP
admet-182	19	16	saturated	saturate	VERB
admet-182	19	17	aqueous	aqueous	ADJ
admet-182	19	18	solutions	solution	NOUN
admet-182	19	19	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-182	19	20	mailto:alex@in-adme.com	mailto:alex@in-adme.com	PROPN
admet-182	19	21	butcher	butcher	NOUN
admet-182	19	22	,	,	PUNCT
admet-182	19	23	comer	comer	NOUN
admet-182	19	24	,	,	PUNCT
admet-182	19	25	avdeef	avdeef	NOUN
admet-182	19	26	admet	admet	PROPN
admet-182	19	27	&	&	CCONJ
admet-182	19	28	dmpk	dmpk	PROPN
admet-182	19	29	3(2	3(2	NUM
admet-182	19	30	)	)	PUNCT
admet-182	19	31	(	(	PUNCT
admet-182	19	32	2015	2015	NUM
admet-182	19	33	)	)	PUNCT
admet-182	19	34	131	131	NUM
admet-182	19	35	-	-	SYM
admet-182	19	36	140	140	NUM
admet-182	19	37	132	132	NUM
admet-182	20	1	[	[	X
admet-182	20	2	9,10	9,10	NUM
admet-182	20	3	]	]	X
admet-182	20	4	,	,	PUNCT
admet-182	20	5	especially	especially	ADV
admet-182	20	6	under	under	ADP
admet-182	20	7	the	the	DET
admet-182	20	8	high	high	ADJ
admet-182	20	9	concentrations	concentration	NOUN
admet-182	20	10	used	use	VERB
admet-182	20	11	to	to	PART
admet-182	20	12	characterize	characterize	VERB
admet-182	20	13	drug	drug	NOUN
admet-182	20	14	-	-	PUNCT
admet-182	20	15	salt	salt	NOUN
admet-182	20	16	precipitates	precipitate	NOUN
admet-182	20	17	[	[	X
admet-182	20	18	11,12	11,12	NUM
admet-182	20	19	]	]	PUNCT
admet-182	20	20	.	.	PUNCT
admet-182	21	1	these	these	DET
admet-182	21	2	complications	complication	NOUN
admet-182	21	3	are	be	AUX
admet-182	21	4	not	not	PART
admet-182	21	5	taken	take	VERB
admet-182	21	6	into	into	ADP
admet-182	21	7	account	account	NOUN
admet-182	21	8	in	in	ADP
admet-182	21	9	sph	sph	PROPN
admet-182	21	10	-	-	PUNCT
admet-182	21	11	pka	pka	PROPN
admet-182	21	12	determinations	determination	NOUN
admet-182	21	13	.	.	PUNCT
admet-182	22	1	reliable	reliable	ADJ
admet-182	22	2	and	and	CCONJ
admet-182	22	3	widely	widely	ADV
admet-182	22	4	-	-	PUNCT
admet-182	22	5	available	available	ADJ
admet-182	22	6	pka	pka	PROPN
admet-182	22	7	methods	method	NOUN
admet-182	22	8	have	have	AUX
admet-182	22	9	been	be	AUX
admet-182	22	10	developed	develop	VERB
admet-182	22	11	over	over	ADP
admet-182	22	12	the	the	DET
admet-182	22	13	last	last	ADJ
admet-182	22	14	two	two	NUM
admet-182	22	15	decades	decade	NOUN
admet-182	22	16	to	to	PART
admet-182	22	17	measure	measure	VERB
admet-182	22	18	the	the	DET
admet-182	22	19	pka	pka	NOUN
admet-182	22	20	of	of	ADP
admet-182	22	21	practically	practically	ADV
admet-182	22	22	-	-	PUNCT
admet-182	22	23	insoluble	insoluble	ADJ
admet-182	22	24	molecules	molecule	NOUN
admet-182	22	25	,	,	PUNCT
admet-182	22	26	under	under	ADP
admet-182	22	27	conditions	condition	NOUN
admet-182	22	28	where	where	SCONJ
admet-182	22	29	saturation	saturation	NOUN
admet-182	22	30	is	be	AUX
admet-182	22	31	avoided	avoid	VERB
admet-182	22	32	and	and	CCONJ
admet-182	22	33	self	self	NOUN
admet-182	22	34	-	-	PUNCT
admet-182	22	35	aggregation	aggregation	NOUN
admet-182	22	36	is	be	AUX
admet-182	22	37	minimized	minimize	VERB
admet-182	22	38	[	[	X
admet-182	22	39	13,14	13,14	NUM
admet-182	22	40	]	]	PUNCT
admet-182	22	41	.	.	PUNCT
admet-182	23	1	potentiometric	potentiometric	PROPN
admet-182	23	2	and	and	CCONJ
admet-182	23	3	uv	uv	NOUN
admet-182	23	4	methods	method	NOUN
admet-182	23	5	are	be	AUX
admet-182	23	6	particularly	particularly	ADV
admet-182	23	7	well	well	ADV
admet-182	23	8	-	-	PUNCT
admet-182	23	9	suited	suited	ADJ
admet-182	23	10	for	for	ADP
admet-182	23	11	measuring	measure	VERB
admet-182	23	12	pka	pka	PROPN
admet-182	23	13	values	value	NOUN
admet-182	23	14	.	.	PUNCT
admet-182	24	1	the	the	DET
admet-182	24	2	yasuda	yasuda	NOUN
admet-182	24	3	-	-	PUNCT
admet-182	24	4	shedlovsky	shedlovsky	NOUN
admet-182	24	5	[	[	X
admet-182	24	6	15	15	NUM
admet-182	24	7	]	]	PUNCT
admet-182	24	8	and	and	CCONJ
admet-182	24	9	origin	origin	NOUN
admet-182	24	10	-	-	PUNCT
admet-182	24	11	shifted	shift	VERB
admet-182	24	12	yasuda	yasuda	NOUN
admet-182	24	13	-	-	PUNCT
admet-182	24	14	shedlovsky	shedlovsky	NOUN
admet-182	24	15	[	[	X
admet-182	24	16	9	9	NUM
admet-182	24	17	]	]	X
admet-182	24	18	methods	method	NOUN
admet-182	24	19	employing	employ	VERB
admet-182	24	20	cosolvents	cosolvent	NOUN
admet-182	24	21	have	have	AUX
admet-182	24	22	been	be	AUX
admet-182	24	23	amply	amply	ADV
admet-182	24	24	demonstrated	demonstrate	VERB
admet-182	24	25	to	to	PART
admet-182	24	26	determine	determine	VERB
admet-182	24	27	accurate	accurate	ADJ
admet-182	24	28	pkas	pkas	NOUN
admet-182	24	29	of	of	ADP
admet-182	24	30	molecules	molecule	NOUN
admet-182	24	31	,	,	PUNCT
admet-182	24	32	some	some	PRON
admet-182	24	33	with	with	ADP
admet-182	24	34	solubility	solubility	NOUN
admet-182	24	35	as	as	ADV
admet-182	24	36	low	low	ADJ
admet-182	24	37	as	as	ADP
admet-182	24	38	2	2	NUM
admet-182	24	39	pg	pg	NOUN
admet-182	24	40	/	/	SYM
admet-182	24	41	ml	ml	PROPN
admet-182	24	42	(	(	PUNCT
admet-182	24	43	amiodarone[11,12	amiodarone[11,12	PROPN
admet-182	24	44	]	]	NUM
admet-182	24	45	)	)	PUNCT
admet-182	24	46	.	.	PUNCT
admet-182	25	1	in	in	ADP
admet-182	25	2	this	this	DET
admet-182	25	3	study	study	NOUN
admet-182	25	4	we	we	PRON
admet-182	25	5	considered	consider	VERB
admet-182	25	6	two	two	NUM
admet-182	25	7	weak	weak	ADJ
admet-182	25	8	bases	basis	NOUN
admet-182	25	9	(	(	PUNCT
admet-182	25	10	fig	fig	NOUN
admet-182	25	11	.	.	NOUN
admet-182	25	12	1	1	NUM
admet-182	25	13	)	)	PUNCT
admet-182	25	14	,	,	PUNCT
admet-182	25	15	pg-300995	pg-300995	PROPN
admet-182	25	16	(	(	PUNCT
admet-182	25	17	anti	anti	ADJ
admet-182	25	18	-	-	ADJ
admet-182	25	19	hiv	hiv	ADJ
admet-182	25	20	agent	agent	NOUN
admet-182	25	21	)	)	PUNCT
admet-182	25	22	and	and	CCONJ
admet-182	25	23	nsc-639829	nsc-639829	NOUN
admet-182	25	24	(	(	PUNCT
admet-182	25	25	anti	anti	ADJ
admet-182	25	26	-	-	ADJ
admet-182	25	27	tumor	tumor	ADJ
admet-182	25	28	agent	agent	NOUN
admet-182	25	29	)	)	PUNCT
admet-182	25	30	,	,	PUNCT
admet-182	25	31	whose	whose	DET
admet-182	25	32	log	log	NOUN
admet-182	25	33	s	s	PART
admet-182	25	34	–	–	PUNCT
admet-182	25	35	ph	ph	ADJ
admet-182	25	36	profiles	profile	NOUN
admet-182	25	37	have	have	AUX
admet-182	25	38	been	be	AUX
admet-182	25	39	published	publish	VERB
admet-182	25	40	by	by	ADP
admet-182	25	41	ran	run	VERB
admet-182	25	42	et	et	PROPN
admet-182	25	43	al	al	PROPN
admet-182	25	44	.	.	PUNCT
admet-182	26	1	[	[	X
admet-182	26	2	16	16	NUM
admet-182	26	3	]	]	PUNCT
admet-182	26	4	and	and	CCONJ
admet-182	26	5	jain	jain	PROPN
admet-182	26	6	et	et	PROPN
admet-182	26	7	al	al	PROPN
admet-182	26	8	.	.	PUNCT
admet-182	27	1	[	[	X
admet-182	27	2	17	17	NUM
admet-182	27	3	]	]	PUNCT
admet-182	27	4	,	,	PUNCT
admet-182	27	5	respectively	respectively	ADV
admet-182	27	6	.	.	PUNCT
admet-182	27	7	figure	figure	NOUN
admet-182	27	8	1	1	NUM
admet-182	27	9	.	.	PUNCT
admet-182	27	10	structures	structure	NOUN
admet-182	27	11	of	of	ADP
admet-182	27	12	the	the	DET
admet-182	27	13	molecules	molecule	NOUN
admet-182	27	14	considered	consider	VERB
admet-182	27	15	.	.	PUNCT
admet-182	28	1	in	in	ADP
admet-182	28	2	these	these	DET
admet-182	28	3	cases	case	NOUN
admet-182	28	4	,	,	PUNCT
admet-182	28	5	the	the	DET
admet-182	28	6	pka	pka	PROPN
admet-182	28	7	values	value	NOUN
admet-182	28	8	of	of	ADP
admet-182	28	9	the	the	DET
admet-182	28	10	molecules	molecule	NOUN
admet-182	28	11	had	have	AUX
admet-182	28	12	not	not	PART
admet-182	28	13	been	be	AUX
admet-182	28	14	reported	report	VERB
admet-182	28	15	.	.	PUNCT
admet-182	29	1	the	the	DET
admet-182	29	2	undistorted	undistorted	ADJ
admet-182	29	3	shapes	shape	NOUN
admet-182	29	4	[	[	X
admet-182	29	5	9	9	NUM
admet-182	29	6	]	]	PUNCT
admet-182	29	7	of	of	ADP
admet-182	29	8	the	the	DET
admet-182	29	9	two	two	NUM
admet-182	29	10	log	log	NOUN
admet-182	29	11	s	s	ADJ
admet-182	29	12	-	-	PUNCT
admet-182	29	13	ph	ph	ADJ
admet-182	29	14	profiles	profile	NOUN
admet-182	29	15	suggested	suggest	VERB
admet-182	29	16	that	that	SCONJ
admet-182	29	17	the	the	DET
admet-182	29	18	simple	simple	ADJ
admet-182	29	19	weak	weak	ADJ
admet-182	29	20	-	-	PUNCT
admet-182	29	21	base	base	NOUN
admet-182	29	22	henderson	henderson	PROPN
admet-182	29	23	-	-	PUNCT
admet-182	29	24	hasselbalch	hasselbalch	PROPN
admet-182	29	25	equation	equation	NOUN
admet-182	29	26	could	could	AUX
admet-182	29	27	be	be	AUX
admet-182	29	28	used	use	VERB
admet-182	29	29	to	to	PART
admet-182	29	30	describe	describe	VERB
admet-182	29	31	the	the	DET
admet-182	29	32	solubility	solubility	NOUN
admet-182	29	33	-	-	PUNCT
admet-182	29	34	ph	ph	NOUN
admet-182	29	35	relationship	relationship	NOUN
admet-182	29	36	.	.	PUNCT
admet-182	30	1	the	the	DET
admet-182	30	2	data	datum	NOUN
admet-182	30	3	were	be	AUX
admet-182	30	4	first	first	ADV
admet-182	30	5	analyzed	analyze	VERB
admet-182	30	6	by	by	ADP
admet-182	30	7	the	the	DET
admet-182	30	8	sph	sph	PROPN
admet-182	30	9	-	-	PUNCT
admet-182	30	10	pka	pka	PROPN
admet-182	30	11	method	method	NOUN
admet-182	30	12	,	,	PUNCT
admet-182	30	13	using	use	VERB
admet-182	30	14	the	the	DET
admet-182	30	15	computer	computer	NOUN
admet-182	30	16	program	program	NOUN
admet-182	30	17	pdisol	pdisol	NOUN
admet-182	30	18	-	-	PUNCT
admet-182	30	19	x	x	SYM
admet-182	30	20	(	(	PUNCT
admet-182	30	21	in	in	ADP
admet-182	30	22	-	-	PUNCT
admet-182	30	23	adme	adme	NOUN
admet-182	30	24	research	research	NOUN
admet-182	30	25	)	)	PUNCT
admet-182	31	1	[	[	X
admet-182	31	2	10,12,18	10,12,18	X
admet-182	31	3	]	]	X
admet-182	31	4	.	.	PUNCT
admet-182	32	1	these	these	DET
admet-182	32	2	operational	operational	ADJ
admet-182	32	3	pka	pka	PROPN
admet-182	32	4	values	value	NOUN
admet-182	32	5	were	be	AUX
admet-182	32	6	compared	compare	VERB
admet-182	32	7	to	to	ADP
admet-182	32	8	those	those	PRON
admet-182	32	9	predicted	predict	VERB
admet-182	32	10	using	use	VERB
admet-182	32	11	marvinsketch	marvinsketch	PROPN
admet-182	32	12	(	(	PUNCT
admet-182	32	13	chemaxon	chemaxon	NOUN
admet-182	32	14	)	)	PUNCT
admet-182	32	15	,	,	PUNCT
admet-182	32	16	admet	admet	PROPN
admet-182	32	17	predictor	predictor	PROPN
admet-182	32	18	(	(	PUNCT
admet-182	32	19	simulation	simulation	NOUN
admet-182	32	20	plus	plus	CCONJ
admet-182	32	21	)	)	PUNCT
admet-182	32	22	,	,	PUNCT
admet-182	32	23	and	and	CCONJ
admet-182	32	24	acd	acd	NOUN
admet-182	32	25	/	/	SYM
admet-182	32	26	percepta	percepta	NOUN
admet-182	32	27	(	(	PUNCT
admet-182	32	28	acd	acd	NOUN
admet-182	32	29	/	/	SYM
admet-182	32	30	labs	lab	NOUN
admet-182	32	31	)	)	PUNCT
admet-182	32	32	.	.	PUNCT
admet-182	33	1	with	with	ADP
admet-182	33	2	pg-300995	pg-300995	PROPN
admet-182	33	3	(	(	PUNCT
admet-182	33	4	intrinsic	intrinsic	ADJ
admet-182	33	5	solubility	solubility	NOUN
admet-182	33	6	,	,	PUNCT
admet-182	33	7	s0	s0	PROPN
admet-182	33	8	=	=	SYM
admet-182	33	9	51	51	NUM
admet-182	33	10	μg	μg	PROPN
admet-182	33	11	/	/	SYM
admet-182	33	12	ml	ml	PROPN
admet-182	34	1	[	[	X
admet-182	34	2	16	16	NUM
admet-182	34	3	]	]	SYM
admet-182	34	4	)	)	PUNCT
admet-182	34	5	,	,	PUNCT
admet-182	34	6	the	the	DET
admet-182	34	7	agreement	agreement	NOUN
admet-182	34	8	was	be	AUX
admet-182	34	9	reasonably	reasonably	ADV
admet-182	34	10	good	good	ADJ
admet-182	34	11	with	with	ADP
admet-182	34	12	two	two	NUM
admet-182	34	13	of	of	ADP
admet-182	34	14	the	the	DET
admet-182	34	15	three	three	NUM
admet-182	34	16	prediction	prediction	NOUN
admet-182	34	17	programs	program	NOUN
admet-182	34	18	.	.	PUNCT
admet-182	35	1	however	however	ADV
admet-182	35	2	,	,	PUNCT
admet-182	35	3	with	with	ADP
admet-182	35	4	the	the	DET
admet-182	35	5	practically	practically	ADV
admet-182	35	6	-	-	PUNCT
admet-182	35	7	insoluble	insoluble	ADJ
admet-182	35	8	nsc-639829	nsc-639829	NOUN
admet-182	35	9	(	(	PUNCT
admet-182	35	10	s0	s0	PROPN
admet-182	35	11	≈	≈	PROPN
admet-182	35	12	30	30	NUM
admet-182	35	13	ng	ng	NOUN
admet-182	35	14	/	/	SYM
admet-182	35	15	ml	ml	PROPN
admet-182	36	1	[	[	X
admet-182	36	2	17	17	NUM
admet-182	36	3	]	]	NUM
admet-182	36	4	)	)	PUNCT
admet-182	36	5	,	,	PUNCT
admet-182	36	6	there	there	PRON
admet-182	36	7	was	be	VERB
admet-182	36	8	a	a	DET
admet-182	36	9	substantial	substantial	ADJ
admet-182	36	10	differences	difference	NOUN
admet-182	36	11	between	between	ADP
admet-182	36	12	the	the	DET
admet-182	36	13	prediction	prediction	NOUN
admet-182	36	14	and	and	CCONJ
admet-182	36	15	the	the	DET
admet-182	36	16	value	value	NOUN
admet-182	36	17	determined	determine	VERB
admet-182	36	18	by	by	ADP
admet-182	36	19	the	the	DET
admet-182	36	20	sph	sph	PROPN
admet-182	36	21	-	-	PUNCT
admet-182	36	22	pka	pka	PROPN
admet-182	36	23	method	method	NOUN
admet-182	36	24	.	.	PUNCT
admet-182	37	1	to	to	PART
admet-182	37	2	address	address	VERB
admet-182	37	3	the	the	DET
admet-182	37	4	apparent	apparent	ADJ
admet-182	37	5	inconsistency	inconsistency	NOUN
admet-182	37	6	,	,	PUNCT
admet-182	37	7	it	it	PRON
admet-182	37	8	was	be	AUX
admet-182	37	9	decided	decide	VERB
admet-182	37	10	to	to	PART
admet-182	37	11	measure	measure	VERB
admet-182	37	12	the	the	DET
admet-182	37	13	pka	pka	NOUN
admet-182	37	14	of	of	ADP
admet-182	37	15	nsc-639829	nsc-639829	NOUN
admet-182	37	16	using	use	VERB
admet-182	37	17	dedicated	dedicated	ADJ
admet-182	37	18	instrumentation	instrumentation	NOUN
admet-182	37	19	which	which	PRON
admet-182	37	20	can	can	AUX
admet-182	37	21	determine	determine	VERB
admet-182	37	22	pka	pka	PROPN
admet-182	37	23	values	value	NOUN
admet-182	37	24	to	to	ADP
admet-182	37	25	high	high	ADJ
admet-182	37	26	precision	precision	NOUN
admet-182	37	27	.	.	PUNCT
admet-182	38	1	using	use	VERB
admet-182	38	2	the	the	DET
admet-182	38	3	measured	measured	ADJ
admet-182	38	4	pka	pka	PROPN
admet-182	38	5	,	,	PUNCT
admet-182	38	6	the	the	DET
admet-182	38	7	log	log	NOUN
admet-182	38	8	s	s	NOUN
admet-182	38	9	ph	ph	NOUN
admet-182	38	10	profile	profile	NOUN
admet-182	38	11	of	of	ADP
admet-182	38	12	nsc-639829	nsc-639829	NOUN
admet-182	38	13	was	be	AUX
admet-182	38	14	rationalized	rationalize	VERB
admet-182	38	15	with	with	ADP
admet-182	38	16	a	a	DET
admet-182	38	17	monocationic	monocationic	ADJ
admet-182	38	18	dimeric	dimeric	ADJ
admet-182	38	19	species	specie	NOUN
admet-182	38	20	,	,	PUNCT
admet-182	38	21	predominating	predominate	VERB
admet-182	38	22	below	below	ADP
admet-182	38	23	ph	ph	ADJ
admet-182	38	24	4	4	NUM
admet-182	38	25	.	.	PUNCT
admet-182	39	1	(	(	PUNCT
admet-182	39	2	we	we	PRON
admet-182	39	3	could	could	AUX
admet-182	39	4	not	not	PART
admet-182	39	5	obtain	obtain	VERB
admet-182	39	6	samples	sample	NOUN
admet-182	39	7	of	of	ADP
admet-182	39	8	pg-300995	pg-300995	NOUN
admet-182	39	9	to	to	PART
admet-182	39	10	do	do	VERB
admet-182	39	11	the	the	DET
admet-182	39	12	experimental	experimental	ADJ
admet-182	39	13	pka	pka	PROPN
admet-182	39	14	determination	determination	NOUN
admet-182	39	15	.	.	PUNCT
admet-182	39	16	)	)	PUNCT
admet-182	40	1	experimental	experimental	ADJ
admet-182	40	2	materials	material	NOUN
admet-182	40	3	nsc-639829	nsc-639829	NOUN
admet-182	40	4	(	(	PUNCT
admet-182	40	5	>	>	SYM
admet-182	40	6	99	99	NUM
admet-182	40	7	%	%	NOUN
admet-182	40	8	purity	purity	NOUN
admet-182	40	9	)	)	PUNCT
admet-182	40	10	was	be	AUX
admet-182	40	11	synthesized	synthesize	VERB
admet-182	40	12	by	by	ADP
admet-182	40	13	the	the	DET
admet-182	40	14	national	national	PROPN
admet-182	40	15	cancer	cancer	PROPN
admet-182	40	16	institute	institute	PROPN
admet-182	40	17	and	and	CCONJ
admet-182	40	18	was	be	AUX
admet-182	40	19	used	use	VERB
admet-182	40	20	as	as	SCONJ
admet-182	40	21	received	receive	VERB
admet-182	40	22	in	in	ADP
admet-182	40	23	the	the	DET
admet-182	40	24	jain	jain	PROPN
admet-182	40	25	et	et	PROPN
admet-182	40	26	al	al	PROPN
admet-182	40	27	.	.	PUNCT
admet-182	41	1	[	[	X
admet-182	41	2	17	17	NUM
admet-182	41	3	]	]	PUNCT
admet-182	41	4	study	study	NOUN
admet-182	41	5	.	.	PUNCT
admet-182	42	1	in	in	ADP
admet-182	42	2	the	the	DET
admet-182	42	3	ran	ran	NOUN
admet-182	42	4	et	et	PROPN
admet-182	42	5	al	al	PROPN
admet-182	42	6	.	.	PUNCT
admet-182	43	1	[	[	X
admet-182	43	2	16	16	NUM
admet-182	43	3	]	]	X
admet-182	43	4	study	study	NOUN
admet-182	43	5	,	,	PUNCT
admet-182	43	6	pg-300995	pg-300995	PROPN
admet-182	43	7	was	be	AUX
admet-182	43	8	a	a	DET
admet-182	43	9	gift	gift	NOUN
admet-182	43	10	from	from	ADP
admet-182	43	11	proctor	proctor	NOUN
admet-182	43	12	and	and	CCONJ
admet-182	43	13	gamble	gamble	NOUN
admet-182	43	14	.	.	PUNCT
admet-182	44	1	methanol	methanol	NOUN
admet-182	44	2	was	be	AUX
admet-182	44	3	purchased	purchase	VERB
admet-182	44	4	from	from	ADP
admet-182	44	5	sigma	sigma	PROPN
admet-182	44	6	-	-	PUNCT
admet-182	44	7	aldrich	aldrich	PROPN
admet-182	44	8	,	,	PUNCT
admet-182	44	9	st	st	PROPN
admet-182	44	10	.	.	PROPN
admet-182	44	11	louis	louis	PROPN
admet-182	44	12	,	,	PUNCT
admet-182	44	13	mo	mo	PROPN
admet-182	44	14	,	,	PUNCT
admet-182	44	15	usa	usa	PROPN
admet-182	44	16	.	.	PROPN
admet-182	44	17	solutions	solution	NOUN
admet-182	44	18	and	and	CCONJ
admet-182	44	19	solvent	solvent	NOUN
admet-182	44	20	mixtures	mixture	NOUN
admet-182	44	21	were	be	AUX
admet-182	44	22	made	make	VERB
admet-182	44	23	with	with	ADP
admet-182	44	24	distilled	distil	VERB
admet-182	44	25	water	water	NOUN
admet-182	44	26	purchased	purchase	VERB
admet-182	44	27	from	from	ADP
admet-182	44	28	emd	emd	PROPN
admet-182	44	29	millipore	millipore	PROPN
admet-182	44	30	,	,	PUNCT
admet-182	44	31	billerica	billerica	PROPN
admet-182	44	32	,	,	PUNCT
admet-182	44	33	ma	ma	PROPN
admet-182	44	34	,	,	PUNCT
admet-182	44	35	usa	usa	PROPN
admet-182	44	36	.	.	PROPN
admet-182	44	37	analytical	analytical	ADJ
admet-182	44	38	grade	grade	NOUN
admet-182	44	39	potassium	potassium	NOUN
admet-182	44	40	hydrogen	hydrogen	NOUN
admet-182	44	41	phthalate	phthalate	NOUN
admet-182	44	42	and	and	CCONJ
admet-182	44	43	kcl	kcl	PROPN
admet-182	44	44	were	be	AUX
admet-182	44	45	purchased	purchase	VERB
admet-182	44	46	from	from	ADP
admet-182	44	47	acros	acros	PROPN
admet-182	44	48	organics	organic	NOUN
admet-182	44	49	,	,	PUNCT
admet-182	44	50	new	new	PROPN
admet-182	44	51	jersey	jersey	PROPN
admet-182	44	52	,	,	PUNCT
admet-182	44	53	usa	usa	PROPN
admet-182	44	54	.	.	PUNCT
admet-182	45	1	the	the	DET
admet-182	45	2	ionic	ionic	ADJ
admet-182	45	3	strength	strength	NOUN
admet-182	45	4	of	of	ADP
admet-182	45	5	water	water	NOUN
admet-182	45	6	was	be	AUX
admet-182	45	7	adjusted	adjust	VERB
admet-182	45	8	to	to	ADP
admet-182	45	9	0.15	0.15	NUM
admet-182	45	10	m	m	NOUN
admet-182	45	11	with	with	ADP
admet-182	45	12	kcl	kcl	PROPN
admet-182	45	13	.	.	PUNCT
admet-182	46	1	the	the	DET
admet-182	46	2	admet	admet	PROPN
admet-182	46	3	&	&	CCONJ
admet-182	46	4	dmpk	dmpk	PROPN
admet-182	46	5	3(2	3(2	NUM
admet-182	46	6	)	)	PUNCT
admet-182	46	7	(	(	PUNCT
admet-182	46	8	2015	2015	NUM
admet-182	46	9	)	)	PUNCT
admet-182	46	10	131	131	NUM
admet-182	46	11	-	-	SYM
admet-182	46	12	140	140	NUM
admet-182	46	13	pka	pka	NOUN
admet-182	46	14	-	-	PUNCT
admet-182	46	15	critical	critical	ADJ
admet-182	46	16	interpretations	interpretation	NOUN
admet-182	46	17	of	of	ADP
admet-182	46	18	solubility	solubility	NOUN
admet-182	46	19	-	-	PUNCT
admet-182	46	20	ph	ph	ADJ
admet-182	46	21	profiles	profile	NOUN
admet-182	46	22	doi	doi	NOUN
admet-182	46	23	:	:	PUNCT
admet-182	46	24	10.5599	10.5599	NUM
admet-182	46	25	/	/	SYM
admet-182	46	26	admet.3.2.182	admet.3.2.182	NOUN
admet-182	46	27	133	133	NUM
admet-182	46	28	base	base	NOUN
admet-182	46	29	titrant	titrant	NOUN
admet-182	46	30	was	be	AUX
admet-182	46	31	prepared	prepare	VERB
admet-182	46	32	by	by	ADP
admet-182	46	33	diluting	dilute	VERB
admet-182	46	34	co2	co2	NOUN
admet-182	46	35	-	-	PUNCT
admet-182	46	36	free	free	ADJ
admet-182	46	37	koh	koh	PROPN
admet-182	46	38	concentrate	concentrate	NOUN
admet-182	46	39	(	(	PUNCT
admet-182	46	40	fluka	fluka	PROPN
admet-182	46	41	analytical	analytical	NOUN
admet-182	46	42	,	,	PUNCT
admet-182	46	43	st	st	PROPN
admet-182	46	44	.	.	PROPN
admet-182	46	45	louis	louis	PROPN
admet-182	46	46	,	,	PUNCT
admet-182	46	47	mo	mo	PROPN
admet-182	46	48	,	,	PUNCT
admet-182	46	49	usa	usa	PROPN
admet-182	46	50	)	)	PUNCT
admet-182	46	51	to	to	ADP
admet-182	46	52	0.5	0.5	NUM
admet-182	46	53	m.	m.	NOUN
admet-182	46	54	it	it	PRON
admet-182	46	55	was	be	AUX
admet-182	46	56	standardized	standardize	VERB
admet-182	46	57	by	by	ADP
admet-182	46	58	titration	titration	NOUN
admet-182	46	59	against	against	ADP
admet-182	46	60	potassium	potassium	NOUN
admet-182	46	61	hydrogen	hydrogen	NOUN
admet-182	46	62	phthalate	phthalate	NOUN
admet-182	46	63	.	.	PUNCT
admet-182	47	1	the	the	DET
admet-182	47	2	acid	acid	PROPN
admet-182	47	3	titrant	titrant	NOUN
admet-182	47	4	,	,	PUNCT
admet-182	47	5	standardized	standardize	VERB
admet-182	47	6	0.5	0.5	NUM
admet-182	47	7	m	m	NOUN
admet-182	47	8	hcl	hcl	PROPN
admet-182	47	9	,	,	PUNCT
admet-182	47	10	was	be	AUX
admet-182	47	11	purchased	purchase	VERB
admet-182	47	12	from	from	ADP
admet-182	47	13	sigma	sigma	PROPN
admet-182	47	14	-	-	PUNCT
admet-182	47	15	aldrich	aldrich	PROPN
admet-182	47	16	st	st	PROPN
admet-182	47	17	.	.	PROPN
admet-182	47	18	louis	louis	PROPN
admet-182	47	19	,	,	PUNCT
admet-182	47	20	mo	mo	PROPN
admet-182	47	21	,	,	PUNCT
admet-182	47	22	usa	usa	PROPN
admet-182	47	23	.	.	PROPN
admet-182	47	24	legacy	legacy	NOUN
admet-182	47	25	solubility	solubility	NOUN
admet-182	47	26	data	data	VERB
admet-182	47	27	the	the	DET
admet-182	47	28	ran	ran	NOUN
admet-182	47	29	et	et	PROPN
admet-182	47	30	al	al	PROPN
admet-182	47	31	.	.	PUNCT
admet-182	48	1	[	[	X
admet-182	48	2	16	16	NUM
admet-182	48	3	]	]	PUNCT
admet-182	48	4	and	and	CCONJ
admet-182	48	5	jain	jain	PROPN
admet-182	48	6	et	et	PROPN
admet-182	48	7	al	al	PROPN
admet-182	48	8	.	.	PUNCT
admet-182	49	1	[	[	X
admet-182	49	2	17	17	NUM
admet-182	49	3	]	]	PUNCT
admet-182	49	4	shake	shake	NOUN
admet-182	49	5	-	-	PUNCT
admet-182	49	6	flask	flask	NOUN
admet-182	49	7	solubility	solubility	NOUN
admet-182	49	8	protocols	protocol	NOUN
admet-182	49	9	were	be	AUX
admet-182	49	10	very	very	ADV
admet-182	49	11	similar	similar	ADJ
admet-182	49	12	.	.	PUNCT
admet-182	50	1	briefly	briefly	ADV
admet-182	50	2	,	,	PUNCT
admet-182	50	3	excess	excess	ADV
admet-182	50	4	solid	solid	ADJ
admet-182	50	5	was	be	AUX
admet-182	50	6	added	add	VERB
admet-182	50	7	to	to	ADP
admet-182	50	8	1	1	NUM
admet-182	50	9	-	-	SYM
admet-182	50	10	2	2	NUM
admet-182	50	11	ml	ml	NOUN
admet-182	50	12	of	of	ADP
admet-182	50	13	buffer	buffer	NOUN
admet-182	50	14	solution	solution	NOUN
admet-182	50	15	.	.	PUNCT
admet-182	51	1	enough	enough	ADJ
admet-182	51	2	nacl	nacl	NOUN
admet-182	51	3	had	have	AUX
admet-182	51	4	been	be	AUX
admet-182	51	5	added	add	VERB
admet-182	51	6	to	to	ADP
admet-182	51	7	the	the	DET
admet-182	51	8	buffers	buffer	NOUN
admet-182	51	9	to	to	PART
admet-182	51	10	produce	produce	VERB
admet-182	51	11	a	a	DET
admet-182	51	12	total	total	ADJ
admet-182	51	13	ionic	ionic	ADJ
admet-182	51	14	strength	strength	NOUN
admet-182	51	15	,	,	PUNCT
admet-182	52	1	i	i	PRON
admet-182	52	2	=	=	NOUN
admet-182	52	3	0.2	0.2	NUM
admet-182	52	4	m.	m.	NOUN
admet-182	52	5	the	the	DET
admet-182	52	6	suspensions	suspension	NOUN
admet-182	52	7	were	be	AUX
admet-182	52	8	agitated	agitate	VERB
admet-182	52	9	mildly	mildly	ADV
admet-182	52	10	for	for	ADP
admet-182	52	11	5	5	NUM
admet-182	52	12	d	d	NOUN
admet-182	52	13	at	at	ADP
admet-182	52	14	23	23	NUM
admet-182	52	15	°	°	ADP
admet-182	52	16	c	c	NOUN
admet-182	52	17	for	for	ADP
admet-182	52	18	nsc639829	nsc639829	ADJ
admet-182	52	19	and	and	CCONJ
admet-182	52	20	7	7	NUM
admet-182	52	21	-	-	SYM
admet-182	52	22	10	10	NUM
admet-182	52	23	d	d	NOUN
admet-182	52	24	at	at	ADP
admet-182	52	25	25	25	NUM
admet-182	52	26	°	°	NOUN
admet-182	52	27	c	c	NOUN
admet-182	52	28	for	for	ADP
admet-182	52	29	pg-300995	pg-300995	NOUN
admet-182	52	30	.	.	PUNCT
admet-182	53	1	at	at	ADP
admet-182	53	2	the	the	DET
admet-182	53	3	end	end	NOUN
admet-182	53	4	of	of	ADP
admet-182	53	5	the	the	DET
admet-182	53	6	stirring	stirring	ADJ
admet-182	53	7	period	period	NOUN
admet-182	53	8	,	,	PUNCT
admet-182	53	9	ph	ph	PROPN
admet-182	53	10	was	be	AUX
admet-182	53	11	read	read	VERB
admet-182	53	12	,	,	PUNCT
admet-182	53	13	after	after	ADP
admet-182	53	14	which	which	PRON
admet-182	53	15	the	the	DET
admet-182	53	16	solutions	solution	NOUN
admet-182	53	17	were	be	AUX
admet-182	53	18	filtered	filter	VERB
admet-182	53	19	and	and	CCONJ
admet-182	53	20	the	the	DET
admet-182	53	21	concentrations	concentration	NOUN
admet-182	53	22	were	be	AUX
admet-182	53	23	determined	determine	VERB
admet-182	53	24	by	by	ADP
admet-182	53	25	hplc	hplc	PROPN
admet-182	53	26	.	.	PUNCT
admet-182	54	1	mostly	mostly	ADV
admet-182	54	2	10	10	NUM
admet-182	54	3	mm	mm	NOUN
admet-182	54	4	buffers	buffer	NOUN
admet-182	54	5	were	be	AUX
admet-182	54	6	used	use	VERB
admet-182	54	7	:	:	PUNCT
admet-182	54	8	glycine	glycine	NOUN
admet-182	54	9	/	/	SYM
admet-182	54	10	hcl	hcl	PROPN
admet-182	54	11	for	for	ADP
admet-182	54	12	ph	ph	X
admet-182	54	13	<	<	X
admet-182	54	14	3	3	NUM
admet-182	54	15	,	,	PUNCT
admet-182	54	16	citrate	citrate	NOUN
admet-182	54	17	for	for	ADP
admet-182	54	18	ph	ph	ADJ
admet-182	54	19	3	3	NUM
admet-182	54	20	-	-	SYM
admet-182	54	21	5	5	NUM
admet-182	54	22	,	,	PUNCT
admet-182	54	23	phosphate	phosphate	VERB
admet-182	54	24	for	for	ADP
admet-182	54	25	ph	ph	ADJ
admet-182	54	26	5	5	NUM
admet-182	54	27	-	-	SYM
admet-182	54	28	8	8	NUM
admet-182	54	29	,	,	PUNCT
admet-182	54	30	and	and	CCONJ
admet-182	54	31	glycine	glycine	NOUN
admet-182	54	32	/	/	SYM
admet-182	54	33	naoh	naoh	NOUN
admet-182	54	34	for	for	ADP
admet-182	54	35	ph	ph	PROPN
admet-182	54	36	>	>	X
admet-182	54	37	8	8	NUM
admet-182	54	38	.	.	PUNCT
admet-182	55	1	the	the	DET
admet-182	55	2	data	datum	NOUN
admet-182	55	3	used	use	VERB
admet-182	55	4	in	in	ADP
admet-182	55	5	this	this	DET
admet-182	55	6	study	study	NOUN
admet-182	55	7	were	be	AUX
admet-182	55	8	digitized	digitize	VERB
admet-182	55	9	from	from	ADP
admet-182	55	10	the	the	DET
admet-182	55	11	log	log	NOUN
admet-182	55	12	s	s	PART
admet-182	55	13	–	–	PUNCT
admet-182	55	14	ph	ph	ADJ
admet-182	55	15	plots	plot	NOUN
admet-182	55	16	in	in	ADP
admet-182	55	17	the	the	DET
admet-182	55	18	original	original	ADJ
admet-182	55	19	publications	publication	NOUN
admet-182	55	20	(	(	PUNCT
admet-182	55	21	11	11	NUM
admet-182	55	22	and	and	CCONJ
admet-182	55	23	13	13	NUM
admet-182	55	24	ph	ph	NOUN
admet-182	55	25	points	point	NOUN
admet-182	55	26	for	for	ADP
admet-182	55	27	pg-300995	pg-300995	NOUN
admet-182	55	28	and	and	CCONJ
admet-182	55	29	nsc-639829	nsc-639829	NOUN
admet-182	55	30	,	,	PUNCT
admet-182	55	31	respectively	respectively	ADV
admet-182	55	32	)	)	PUNCT
admet-182	55	33	.	.	PUNCT
admet-182	56	1	spectroscopic	spectroscopic	ADJ
admet-182	56	2	measurement	measurement	NOUN
admet-182	56	3	of	of	ADP
admet-182	56	4	the	the	DET
admet-182	56	5	pka	pka	PROPN
admet-182	56	6	of	of	ADP
admet-182	56	7	nsc-639829	nsc-639829	NOUN
admet-182	56	8	the	the	DET
admet-182	56	9	pka	pka	PROPN
admet-182	56	10	was	be	AUX
admet-182	56	11	determined	determine	VERB
admet-182	56	12	at	at	ADP
admet-182	56	13	25	25	NUM
admet-182	56	14	±	±	NUM
admet-182	56	15	0.1	0.1	NUM
admet-182	56	16	°	°	ADP
admet-182	56	17	c	c	NOUN
admet-182	56	18	using	use	VERB
admet-182	56	19	the	the	DET
admet-182	56	20	siriust3	siriust3	NOUN
admet-182	56	21	uv	uv	NOUN
admet-182	56	22	spectroscopic	spectroscopic	NOUN
admet-182	56	23	(	(	PUNCT
admet-182	56	24	uv	uv	NOUN
admet-182	56	25	-	-	PUNCT
admet-182	56	26	metric	metric	ADJ
admet-182	56	27	)	)	PUNCT
admet-182	56	28	method	method	NOUN
admet-182	56	29	.	.	PUNCT
admet-182	57	1	the	the	DET
admet-182	57	2	sample	sample	NOUN
admet-182	57	3	was	be	AUX
admet-182	57	4	added	add	VERB
admet-182	57	5	to	to	ADP
admet-182	57	6	a	a	DET
admet-182	57	7	siriust3	siriust3	NOUN
admet-182	57	8	vial	vial	NOUN
admet-182	57	9	as	as	ADP
admet-182	57	10	5	5	NUM
admet-182	57	11	microliters	microliter	NOUN
admet-182	57	12	of	of	ADP
admet-182	57	13	10	10	NUM
admet-182	57	14	mm	mm	PROPN
admet-182	57	15	dmso	dmso	NOUN
admet-182	57	16	stock	stock	NOUN
admet-182	57	17	solution	solution	NOUN
admet-182	57	18	and	and	CCONJ
admet-182	57	19	was	be	AUX
admet-182	57	20	initially	initially	ADV
admet-182	57	21	titrated	titrate	VERB
admet-182	57	22	in	in	ADP
admet-182	57	23	a	a	DET
admet-182	57	24	fast	fast	ADJ
admet-182	57	25	-	-	PUNCT
admet-182	57	26	uv	uv	NOUN
admet-182	57	27	pka	pka	PROPN
admet-182	57	28	screening	screen	VERB
admet-182	57	29	assay	assay	VERB
admet-182	57	30	.	.	PUNCT
admet-182	58	1	the	the	DET
admet-182	58	2	sample	sample	NOUN
admet-182	58	3	was	be	AUX
admet-182	58	4	titrated	titrate	VERB
admet-182	58	5	from	from	ADP
admet-182	58	6	ph	ph	PROPN
admet-182	58	7	2	2	NUM
admet-182	58	8	12	12	NUM
admet-182	58	9	at	at	ADP
admet-182	58	10	concentrations	concentration	NOUN
admet-182	58	11	of	of	ADP
admet-182	58	12	32	32	NUM
admet-182	58	13	16	16	NUM
admet-182	58	14	µm	µm	NOUN
admet-182	58	15	under	under	ADP
admet-182	58	16	methanol	methanol	NOUN
admet-182	58	17	-	-	PUNCT
admet-182	58	18	water	water	NOUN
admet-182	58	19	co	co	ADJ
admet-182	58	20	-	-	ADJ
admet-182	58	21	solvent	solvent	ADJ
admet-182	58	22	conditions	condition	NOUN
admet-182	58	23	.	.	PUNCT
admet-182	59	1	only	only	ADV
admet-182	59	2	one	one	NUM
admet-182	59	3	pka	pka	NOUN
admet-182	59	4	,	,	PUNCT
admet-182	59	5	with	with	ADP
admet-182	59	6	a	a	DET
admet-182	59	7	value	value	NOUN
admet-182	59	8	of	of	ADP
admet-182	59	9	3.7	3.7	NUM
admet-182	59	10	,	,	PUNCT
admet-182	59	11	was	be	AUX
admet-182	59	12	observed	observe	VERB
admet-182	59	13	.	.	PUNCT
admet-182	60	1	consequently	consequently	ADV
admet-182	60	2	,	,	PUNCT
admet-182	60	3	5	5	NUM
admet-182	60	4	microliters	microliter	NOUN
admet-182	60	5	of	of	ADP
admet-182	60	6	a	a	DET
admet-182	60	7	10	10	NUM
admet-182	60	8	mm	mm	PROPN
admet-182	60	9	dmso	dmso	NOUN
admet-182	60	10	stock	stock	NOUN
admet-182	60	11	solution	solution	NOUN
admet-182	60	12	of	of	ADP
admet-182	60	13	nsc-639829	nsc-639829	NOUN
admet-182	60	14	were	be	AUX
admet-182	60	15	dispensed	dispense	VERB
admet-182	60	16	into	into	ADP
admet-182	60	17	a	a	DET
admet-182	60	18	siriust3	siriust3	NOUN
admet-182	60	19	vial	vial	NOUN
admet-182	60	20	and	and	CCONJ
admet-182	60	21	the	the	DET
admet-182	60	22	sample	sample	NOUN
admet-182	60	23	was	be	AUX
admet-182	60	24	titrated	titrate	VERB
admet-182	60	25	in	in	ADP
admet-182	60	26	a	a	DET
admet-182	60	27	triple	triple	ADJ
admet-182	60	28	titration	titration	NOUN
admet-182	60	29	from	from	ADP
admet-182	60	30	ph	ph	PROPN
admet-182	60	31	1.5	1.5	NUM
admet-182	60	32	5.0	5.0	NUM
admet-182	60	33	at	at	ADP
admet-182	60	34	concentrations	concentration	NOUN
admet-182	60	35	of	of	ADP
admet-182	60	36	29	29	NUM
admet-182	60	37	14	14	NUM
admet-182	60	38	µm	µm	NOUN
admet-182	60	39	in	in	ADP
admet-182	60	40	three	three	NUM
admet-182	60	41	different	different	ADJ
admet-182	60	42	ratios	ratio	NOUN
admet-182	60	43	of	of	ADP
admet-182	60	44	methanol	methanol	NOUN
admet-182	60	45	-	-	PUNCT
admet-182	60	46	water	water	NOUN
admet-182	60	47	cosolvent	cosolvent	NOUN
admet-182	60	48	.	.	PUNCT
admet-182	61	1	the	the	DET
admet-182	61	2	average	average	ADJ
admet-182	61	3	methanol	methanol	NOUN
admet-182	61	4	concentration	concentration	NOUN
admet-182	61	5	was	be	AUX
admet-182	61	6	40.9	40.9	NUM
admet-182	61	7	,	,	PUNCT
admet-182	61	8	30.2	30.2	NUM
admet-182	61	9	and	and	CCONJ
admet-182	61	10	21.6	21.6	NUM
admet-182	61	11	%	%	NOUN
admet-182	61	12	w	w	PROPN
admet-182	61	13	/	/	SYM
admet-182	61	14	w	w	NOUN
admet-182	61	15	in	in	ADP
admet-182	61	16	the	the	DET
admet-182	61	17	first	first	ADJ
admet-182	61	18	,	,	PUNCT
admet-182	61	19	second	second	ADJ
admet-182	61	20	and	and	CCONJ
admet-182	61	21	third	third	ADJ
admet-182	61	22	titrations	titration	NOUN
admet-182	61	23	,	,	PUNCT
admet-182	61	24	respectively	respectively	ADV
admet-182	61	25	.	.	PUNCT
admet-182	62	1	the	the	DET
admet-182	62	2	presence	presence	NOUN
admet-182	62	3	of	of	ADP
admet-182	62	4	cosolvent	cosolvent	NOUN
admet-182	62	5	caused	cause	VERB
admet-182	62	6	the	the	DET
admet-182	62	7	pka	pka	PROPN
admet-182	62	8	to	to	PART
admet-182	62	9	shift	shift	VERB
admet-182	62	10	from	from	ADP
admet-182	62	11	its	its	PRON
admet-182	62	12	aqueous	aqueous	ADJ
admet-182	62	13	value	value	NOUN
admet-182	62	14	.	.	PUNCT
admet-182	63	1	the	the	DET
admet-182	63	2	apparent	apparent	ADJ
admet-182	63	3	pka	pka	NOUN
admet-182	63	4	in	in	ADP
admet-182	63	5	the	the	DET
admet-182	63	6	presence	presence	NOUN
admet-182	63	7	of	of	ADP
admet-182	63	8	cosolvent	cosolvent	NOUN
admet-182	63	9	is	be	AUX
admet-182	63	10	referred	refer	VERB
admet-182	63	11	to	to	ADP
admet-182	63	12	as	as	ADP
admet-182	63	13	the	the	DET
admet-182	63	14	pska	pska	NOUN
admet-182	63	15	.	.	PUNCT
admet-182	64	1	multi	multi	ADJ
admet-182	64	2	-	-	ADJ
admet-182	64	3	wavelength	wavelength	ADJ
admet-182	64	4	uv	uv	NOUN
admet-182	64	5	spectra	spectra	NOUN
admet-182	64	6	(	(	PUNCT
admet-182	64	7	200	200	NUM
admet-182	64	8	750	750	NUM
admet-182	64	9	nm	nm	NOUN
admet-182	64	10	)	)	PUNCT
admet-182	64	11	and	and	CCONJ
admet-182	64	12	ph	ph	ADJ
admet-182	64	13	data	datum	NOUN
admet-182	64	14	were	be	AUX
admet-182	64	15	collected	collect	VERB
admet-182	64	16	every	every	DET
admet-182	64	17	0.2	0.2	NUM
admet-182	64	18	ph	ph	ADJ
admet-182	64	19	units	unit	NOUN
admet-182	64	20	throughout	throughout	ADP
admet-182	64	21	each	each	DET
admet-182	64	22	titration	titration	NOUN
admet-182	64	23	.	.	PUNCT
admet-182	65	1	the	the	DET
admet-182	65	2	siriust3	siriust3	PROPN
admet-182	65	3	refine	refine	PROPN
admet-182	65	4	software	software	NOUN
admet-182	65	5	used	use	VERB
admet-182	65	6	target	target	NOUN
admet-182	65	7	factor	factor	NOUN
admet-182	65	8	analysis	analysis	NOUN
admet-182	65	9	(	(	PUNCT
admet-182	65	10	tfa	tfa	NOUN
admet-182	65	11	)	)	PUNCT
admet-182	65	12	to	to	PART
admet-182	65	13	rationalize	rationalize	VERB
admet-182	65	14	the	the	DET
admet-182	65	15	3d	3d	NOUN
admet-182	65	16	matrix	matrix	NOUN
admet-182	65	17	of	of	ADP
admet-182	65	18	absorbance	absorbance	NOUN
admet-182	65	19	vs	vs	ADP
admet-182	65	20	wavelength	wavelength	NOUN
admet-182	65	21	vs	vs	ADP
admet-182	65	22	ph	ph	PROPN
admet-182	65	23	.	.	PUNCT
admet-182	66	1	the	the	DET
admet-182	66	2	pska	pska	NOUN
admet-182	66	3	values	value	NOUN
admet-182	66	4	for	for	ADP
admet-182	66	5	each	each	DET
admet-182	66	6	titration	titration	NOUN
admet-182	66	7	were	be	AUX
admet-182	66	8	determined	determine	VERB
admet-182	66	9	as	as	ADP
admet-182	66	10	the	the	DET
admet-182	66	11	point	point	NOUN
admet-182	66	12	at	at	ADP
admet-182	66	13	which	which	PRON
admet-182	66	14	the	the	DET
admet-182	66	15	rate	rate	NOUN
admet-182	66	16	of	of	ADP
admet-182	66	17	uv	uv	NOUN
admet-182	66	18	absorbance	absorbance	NOUN
admet-182	66	19	change	change	NOUN
admet-182	66	20	was	be	AUX
admet-182	66	21	greatest	great	ADJ
admet-182	66	22	across	across	ADP
admet-182	66	23	the	the	DET
admet-182	66	24	selected	select	VERB
admet-182	66	25	wavelength	wavelength	NOUN
admet-182	66	26	range	range	NOUN
admet-182	66	27	as	as	ADP
admet-182	66	28	a	a	DET
admet-182	66	29	function	function	NOUN
admet-182	66	30	of	of	ADP
admet-182	66	31	ph	ph	PROPN
admet-182	66	32	.	.	PUNCT
admet-182	67	1	the	the	DET
admet-182	67	2	aqueous	aqueous	ADJ
admet-182	67	3	pka	pka	PROPN
admet-182	67	4	was	be	AUX
admet-182	67	5	determined	determine	VERB
admet-182	67	6	by	by	ADP
admet-182	67	7	yasuda	yasuda	NOUN
admet-182	67	8	-	-	PUNCT
admet-182	67	9	shedlovsky	shedlovsky	ADJ
admet-182	67	10	extrapolation	extrapolation	NOUN
admet-182	67	11	of	of	ADP
admet-182	67	12	the	the	DET
admet-182	67	13	pska	pska	NOUN
admet-182	67	14	values	value	NOUN
admet-182	67	15	from	from	ADP
admet-182	67	16	each	each	DET
admet-182	67	17	titration	titration	NOUN
admet-182	67	18	.	.	PUNCT
admet-182	68	1	there	there	PRON
admet-182	68	2	was	be	VERB
admet-182	68	3	no	no	DET
admet-182	68	4	evidence	evidence	NOUN
admet-182	68	5	of	of	ADP
admet-182	68	6	significant	significant	ADJ
admet-182	68	7	sample	sample	NOUN
admet-182	68	8	impurities	impurity	NOUN
admet-182	68	9	in	in	ADP
admet-182	68	10	the	the	DET
admet-182	68	11	pka	pka	PROPN
admet-182	68	12	determination	determination	NOUN
admet-182	68	13	.	.	PUNCT
admet-182	69	1	predicted	predict	VERB
admet-182	69	2	pka	pka	PROPN
admet-182	69	3	values	value	NOUN
admet-182	69	4	of	of	ADP
admet-182	69	5	pka	pka	PROPN
admet-182	69	6	were	be	AUX
admet-182	69	7	predicted	predict	VERB
admet-182	69	8	using	use	VERB
admet-182	69	9	marvinsketchtm	marvinsketchtm	PROPN
admet-182	69	10	5.3.7	5.3.7	PROPN
admet-182	69	11	(	(	PUNCT
admet-182	69	12	chemaxon	chemaxon	PROPN
admet-182	69	13	ltd	ltd	PROPN
admet-182	69	14	.	.	PROPN
admet-182	69	15	,	,	PUNCT
admet-182	69	16	budapest	budapest	PROPN
admet-182	69	17	,	,	PUNCT
admet-182	69	18	hungary	hungary	PROPN
admet-182	69	19	;	;	PUNCT
admet-182	69	20	www.chemaxon.com	www.chemaxon.com	NOUN
admet-182	69	21	)	)	PUNCT
admet-182	69	22	,	,	PUNCT
admet-182	69	23	and	and	CCONJ
admet-182	69	24	corroborated	corroborate	VERB
admet-182	69	25	with	with	ADP
admet-182	69	26	admet	admet	PROPN
admet-182	69	27	predictortm	predictortm	PROPN
admet-182	69	28	7.0	7.0	NUM
admet-182	69	29	(	(	PUNCT
admet-182	69	30	simulation	simulation	NOUN
admet-182	69	31	plus	plus	PROPN
admet-182	69	32	,	,	PUNCT
admet-182	69	33	inc	inc	PROPN
admet-182	69	34	.	.	PROPN
admet-182	69	35	,	,	PUNCT
admet-182	69	36	lancaster	lancaster	PROPN
admet-182	69	37	,	,	PUNCT
admet-182	69	38	ca	ca	PROPN
admet-182	69	39	,	,	PUNCT
admet-182	69	40	usa	usa	PROPN
admet-182	69	41	;	;	PUNCT
admet-182	69	42	www.simulations-plus.com	www.simulations-plus.com	X
admet-182	69	43	)	)	PUNCT
admet-182	69	44	,	,	PUNCT
admet-182	69	45	and	and	CCONJ
admet-182	69	46	acd	acd	NOUN
admet-182	69	47	/	/	SYM
admet-182	69	48	perceptatm	perceptatm	NOUN
admet-182	69	49	14	14	NUM
admet-182	69	50	(	(	PUNCT
admet-182	69	51	acd	acd	NOUN
admet-182	69	52	/	/	SYM
admet-182	69	53	labs	labs	PROPN
admet-182	69	54	,	,	PUNCT
admet-182	69	55	toronto	toronto	PROPN
admet-182	69	56	,	,	PUNCT
admet-182	69	57	canada	canada	PROPN
admet-182	69	58	;	;	PUNCT
admet-182	69	59	www.acdlabs.com	www.acdlabs.com	X
admet-182	69	60	)	)	PUNCT
admet-182	69	61	.	.	PUNCT
admet-182	70	1	the	the	DET
admet-182	70	2	predictions	prediction	NOUN
admet-182	70	3	were	be	AUX
admet-182	70	4	used	use	VERB
admet-182	70	5	as	as	ADP
admet-182	70	6	a	a	DET
admet-182	70	7	guide	guide	NOUN
admet-182	70	8	for	for	ADP
admet-182	70	9	some	some	PRON
admet-182	70	10	of	of	ADP
admet-182	70	11	the	the	DET
admet-182	70	12	sph	sph	PROPN
admet-182	70	13	-	-	PUNCT
admet-182	70	14	pka	pka	PROPN
admet-182	70	15	analysis	analysis	NOUN
admet-182	70	16	.	.	PUNCT
admet-182	71	1	refinement	refinement	NOUN
admet-182	71	2	of	of	ADP
admet-182	71	3	intrinsic	intrinsic	ADJ
admet-182	71	4	solubility	solubility	NOUN
admet-182	71	5	,	,	PUNCT
admet-182	71	6	aggregation	aggregation	NOUN
admet-182	71	7	constants	constant	NOUN
admet-182	71	8	,	,	PUNCT
admet-182	71	9	and	and	CCONJ
admet-182	71	10	sph	sph	PROPN
admet-182	71	11	-	-	PUNCT
admet-182	71	12	pka	pka	PROPN
admet-182	71	13	detail	detail	NOUN
admet-182	71	14	of	of	ADP
admet-182	71	15	the	the	DET
admet-182	71	16	mathematical	mathematical	ADJ
admet-182	71	17	approach	approach	NOUN
admet-182	71	18	in	in	ADP
admet-182	71	19	the	the	DET
admet-182	71	20	pdisol	pdisol	NOUN
admet-182	71	21	-	-	PUNCT
admet-182	71	22	x	x	SYM
admet-182	71	23	(	(	PUNCT
admet-182	71	24	in	in	ADP
admet-182	71	25	-	-	PUNCT
admet-182	71	26	adme	adme	NOUN
admet-182	71	27	research	research	NOUN
admet-182	71	28	)	)	PUNCT
admet-182	71	29	computer	computer	NOUN
admet-182	71	30	program	program	NOUN
admet-182	71	31	has	have	AUX
admet-182	71	32	been	be	AUX
admet-182	71	33	described	describe	VERB
admet-182	71	34	by	by	ADP
admet-182	71	35	völgyi	völgyi	PROPN
admet-182	71	36	et	et	PROPN
admet-182	71	37	al	al	PROPN
admet-182	71	38	.	.	PUNCT
admet-182	72	1	[	[	X
admet-182	72	2	18	18	NUM
admet-182	72	3	]	]	PUNCT
admet-182	72	4	.	.	PUNCT
admet-182	73	1	briefly	briefly	NOUN
admet-182	73	2	,	,	PUNCT
admet-182	73	3	the	the	DET
admet-182	73	4	data	datum	NOUN
admet-182	73	5	analysis	analysis	NOUN
admet-182	73	6	method	method	NOUN
admet-182	73	7	uses	uses	AUX
admet-182	73	8	measured	measure	VERB
admet-182	73	9	log	log	NOUN
admet-182	73	10	s	s	PART
admet-182	73	11	ph	ph	VERB
admet-182	73	12	,	,	PUNCT
admet-182	73	13	along	along	ADP
admet-182	73	14	with	with	ADP
admet-182	73	15	standard	standard	ADJ
admet-182	73	16	deviations	deviation	NOUN
admet-182	73	17	,	,	PUNCT
admet-182	73	18	sd	sd	X
admet-182	73	19	(	(	PUNCT
admet-182	73	20	log	log	NOUN
admet-182	73	21	s	s	PART
admet-182	73	22	)	)	PUNCT
admet-182	73	23	,	,	PUNCT
admet-182	73	24	as	as	ADP
admet-182	73	25	input	input	NOUN
admet-182	73	26	into	into	ADP
admet-182	73	27	the	the	DET
admet-182	73	28	pdisol	pdisol	ADJ
admet-182	73	29	-	-	PUNCT
admet-182	73	30	x	x	NOUN
admet-182	73	31	program	program	NOUN
admet-182	73	32	.	.	PUNCT
admet-182	74	1	an	an	DET
admet-182	74	2	algorithm	algorithm	NOUN
admet-182	74	3	was	be	AUX
admet-182	74	4	developed	develop	VERB
admet-182	74	5	which	which	PRON
admet-182	74	6	considers	consider	VERB
admet-182	74	7	the	the	DET
admet-182	74	8	contribution	contribution	NOUN
admet-182	74	9	of	of	ADP
admet-182	74	10	all	all	DET
admet-182	74	11	species	specie	NOUN
admet-182	74	12	proposed	propose	VERB
admet-182	74	13	to	to	PART
admet-182	74	14	be	be	AUX
admet-182	74	15	present	present	ADJ
admet-182	74	16	in	in	ADP
admet-182	74	17	solution	solution	NOUN
admet-182	74	18	,	,	PUNCT
admet-182	74	19	including	include	VERB
admet-182	74	20	all	all	DET
admet-182	74	21	buffer	buffer	NOUN
admet-182	74	22	http://www.chemaxon.com/	http://www.chemaxon.com/	NOUN
admet-182	74	23	http://www.simulations-plus.com/	http://www.simulations-plus.com/	PROPN
admet-182	74	24	http://www.acdlabs.com/	http://www.acdlabs.com/	PROPN
admet-182	74	25	butcher	butcher	NOUN
admet-182	74	26	,	,	PUNCT
admet-182	74	27	comer	comer	PROPN
admet-182	74	28	,	,	PUNCT
admet-182	74	29	avdeef	avdeef	NOUN
admet-182	74	30	admet	admet	PROPN
admet-182	74	31	&	&	CCONJ
admet-182	74	32	dmpk	dmpk	PROPN
admet-182	74	33	3(2	3(2	NUM
admet-182	74	34	)	)	PUNCT
admet-182	74	35	(	(	PUNCT
admet-182	74	36	2015	2015	NUM
admet-182	74	37	)	)	PUNCT
admet-182	74	38	131	131	NUM
admet-182	74	39	-	-	SYM
admet-182	74	40	140	140	NUM
admet-182	74	41	134	134	NUM
admet-182	74	42	components	component	NOUN
admet-182	74	43	(	(	PUNCT
admet-182	74	44	e.g.	e.g.	ADV
admet-182	74	45	,	,	PUNCT
admet-182	74	46	citrate	citrate	NOUN
admet-182	74	47	,	,	PUNCT
admet-182	74	48	phosphate	phosphate	NOUN
admet-182	74	49	,	,	PUNCT
admet-182	74	50	glycine	glycine	NOUN
admet-182	74	51	)	)	PUNCT
admet-182	74	52	.	.	PUNCT
admet-182	75	1	the	the	DET
admet-182	75	2	approach	approach	NOUN
admet-182	75	3	does	do	AUX
admet-182	75	4	not	not	PART
admet-182	75	5	depend	depend	VERB
admet-182	75	6	on	on	ADP
admet-182	75	7	any	any	DET
admet-182	75	8	explicitly	explicitly	ADV
admet-182	75	9	derived	derive	VERB
admet-182	75	10	extensions	extension	NOUN
admet-182	75	11	of	of	ADP
admet-182	75	12	the	the	DET
admet-182	75	13	henderson	henderson	PROPN
admet-182	75	14	-	-	PUNCT
admet-182	75	15	hasselbalch	hasselbalch	PROPN
admet-182	75	16	equations	equation	NOUN
admet-182	75	17	.	.	PUNCT
admet-182	76	1	the	the	DET
admet-182	76	2	computational	computational	ADJ
admet-182	76	3	algorithm	algorithm	NOUN
admet-182	76	4	derives	derive	VERB
admet-182	76	5	its	its	PRON
admet-182	76	6	own	own	ADJ
admet-182	76	7	implicit	implicit	ADJ
admet-182	76	8	equations	equation	NOUN
admet-182	76	9	internally	internally	ADV
admet-182	76	10	,	,	PUNCT
admet-182	76	11	given	give	VERB
admet-182	76	12	any	any	DET
admet-182	76	13	practical	practical	ADJ
admet-182	76	14	number	number	NOUN
admet-182	76	15	of	of	ADP
admet-182	76	16	equilibria	equilibrium	NOUN
admet-182	76	17	and	and	CCONJ
admet-182	76	18	estimated	estimated	ADJ
admet-182	76	19	constants	constant	NOUN
admet-182	76	20	,	,	PUNCT
admet-182	76	21	which	which	PRON
admet-182	76	22	are	be	AUX
admet-182	76	23	subsequently	subsequently	ADV
admet-182	76	24	refined	refine	VERB
admet-182	76	25	by	by	ADP
admet-182	76	26	weighted	weight	VERB
admet-182	76	27	nonlinear	nonlinear	ADJ
admet-182	76	28	least	least	ADJ
admet-182	76	29	-	-	PUNCT
admet-182	76	30	squares	square	NOUN
admet-182	76	31	regression	regression	NOUN
admet-182	76	32	[	[	X
admet-182	76	33	9,18	9,18	X
admet-182	76	34	]	]	PUNCT
admet-182	76	35	.	.	PUNCT
admet-182	77	1	therefore	therefore	ADV
admet-182	77	2	,	,	PUNCT
admet-182	77	3	in	in	ADP
admet-182	77	4	principal	principal	NOUN
admet-182	77	5	,	,	PUNCT
admet-182	77	6	drug	drug	NOUN
admet-182	77	7	-	-	PUNCT
admet-182	77	8	salt	salt	NOUN
admet-182	77	9	precipitates	precipitate	NOUN
admet-182	77	10	,	,	PUNCT
admet-182	77	11	-aggregates	-aggregate	NOUN
admet-182	77	12	,	,	PUNCT
admet-182	77	13	-complexes	-complexe	NOUN
admet-182	77	14	,	,	PUNCT
admet-182	77	15	bile	bile	NOUN
admet-182	77	16	salts	salt	NOUN
admet-182	77	17	,	,	PUNCT
admet-182	77	18	-surfactant	-surfactant	PROPN
admet-182	77	19	can	can	AUX
admet-182	77	20	be	be	AUX
admet-182	77	21	accommodated	accommodate	VERB
admet-182	77	22	[	[	X
admet-182	77	23	4,9,18	4,9,18	X
admet-182	77	24	]	]	PUNCT
admet-182	77	25	.	.	PUNCT
admet-182	78	1	presence	presence	NOUN
admet-182	78	2	of	of	ADP
admet-182	78	3	specific	specific	ADJ
admet-182	78	4	buffer	buffer	NOUN
admet-182	78	5	-	-	PUNCT
admet-182	78	6	drug	drug	NOUN
admet-182	78	7	species	specie	NOUN
admet-182	78	8	can	can	AUX
admet-182	78	9	be	be	AUX
admet-182	78	10	tested	test	VERB
admet-182	78	11	.	.	PUNCT
admet-182	79	1	the	the	DET
admet-182	79	2	program	program	NOUN
admet-182	79	3	assumes	assume	VERB
admet-182	79	4	an	an	DET
admet-182	79	5	initial	initial	ADJ
admet-182	79	6	condition	condition	NOUN
admet-182	79	7	for	for	ADP
admet-182	79	8	the	the	DET
admet-182	79	9	suspension	suspension	NOUN
admet-182	79	10	of	of	ADP
admet-182	79	11	the	the	DET
admet-182	79	12	solid	solid	ADJ
admet-182	79	13	drug	drug	NOUN
admet-182	79	14	in	in	ADP
admet-182	79	15	the	the	DET
admet-182	79	16	buffer	buffer	NOUN
admet-182	79	17	solution	solution	NOUN
admet-182	79	18	,	,	PUNCT
admet-182	79	19	ideally	ideally	ADV
admet-182	79	20	with	with	ADP
admet-182	79	21	the	the	DET
admet-182	79	22	compound	compound	NOUN
admet-182	79	23	remaining	remaining	AUX
admet-182	79	24	saturated	saturate	VERB
admet-182	79	25	over	over	ADP
admet-182	79	26	a	a	DET
admet-182	79	27	wide	wide	ADJ
admet-182	79	28	range	range	NOUN
admet-182	79	29	of	of	ADP
admet-182	79	30	ph	ph	NOUN
admet-182	79	31	.	.	PROPN
admet-182	79	32	first	first	ADV
admet-182	79	33	,	,	PUNCT
admet-182	79	34	the	the	DET
admet-182	79	35	program	program	NOUN
admet-182	79	36	calculates	calculate	VERB
admet-182	79	37	the	the	DET
admet-182	79	38	volume	volume	NOUN
admet-182	79	39	of	of	ADP
admet-182	79	40	acid	acid	PROPN
admet-182	79	41	titrant	titrant	NOUN
admet-182	79	42	that	that	PRON
admet-182	79	43	would	would	AUX
admet-182	79	44	lower	lower	VERB
admet-182	79	45	the	the	DET
admet-182	79	46	ph	ph	NOUN
admet-182	79	47	of	of	ADP
admet-182	79	48	the	the	DET
admet-182	79	49	suspension	suspension	NOUN
admet-182	79	50	to	to	ADP
admet-182	79	51	~0	~0	NUM
admet-182	79	52	.	.	PUNCT
admet-182	80	1	from	from	ADP
admet-182	80	2	there	there	ADV
admet-182	80	3	,	,	PUNCT
admet-182	80	4	a	a	DET
admet-182	80	5	sequence	sequence	NOUN
admet-182	80	6	of	of	ADP
admet-182	80	7	perturbations	perturbation	NOUN
admet-182	80	8	with	with	ADP
admet-182	80	9	standardized	standardized	ADJ
admet-182	80	10	naoh	naoh	NOUN
admet-182	80	11	is	be	AUX
admet-182	80	12	simulated	simulate	VERB
admet-182	80	13	,	,	PUNCT
admet-182	80	14	and	and	CCONJ
admet-182	80	15	solubility	solubility	NOUN
admet-182	80	16	calculated	calculate	VERB
admet-182	80	17	at	at	ADP
admet-182	80	18	each	each	DET
admet-182	80	19	point	point	NOUN
admet-182	80	20	(	(	PUNCT
admet-182	80	21	in	in	ADP
admet-182	80	22	ph	ph	ADJ
admet-182	80	23	steps	step	NOUN
admet-182	80	24	of	of	ADP
admet-182	80	25	0.005	0.005	NUM
admet-182	80	26	-	-	PUNCT
admet-182	80	27	0.2	0.2	NUM
admet-182	80	28	)	)	PUNCT
admet-182	80	29	,	,	PUNCT
admet-182	80	30	until	until	SCONJ
admet-182	80	31	ph	ph	NOUN
admet-182	80	32	~	~	PUNCT
admet-182	80	33	13	13	NUM
admet-182	80	34	is	be	AUX
admet-182	80	35	reached	reach	VERB
admet-182	80	36	.	.	PUNCT
admet-182	81	1	the	the	DET
admet-182	81	2	ionic	ionic	ADJ
admet-182	81	3	strength	strength	NOUN
admet-182	81	4	is	be	AUX
admet-182	81	5	rigorously	rigorously	ADV
admet-182	81	6	calculated	calculate	VERB
admet-182	81	7	at	at	ADP
admet-182	81	8	each	each	DET
admet-182	81	9	step	step	NOUN
admet-182	81	10	,	,	PUNCT
admet-182	81	11	and	and	CCONJ
admet-182	81	12	pka	pka	PROPN
admet-182	81	13	values	value	NOUN
admet-182	81	14	(	(	PUNCT
admet-182	81	15	as	as	ADV
admet-182	81	16	well	well	ADV
admet-182	81	17	as	as	ADP
admet-182	81	18	solubility	solubility	NOUN
admet-182	81	19	products	product	NOUN
admet-182	81	20	,	,	PUNCT
admet-182	81	21	aggregation	aggregation	NOUN
admet-182	81	22	and	and	CCONJ
admet-182	81	23	complexation	complexation	NOUN
admet-182	81	24	constants	constant	NOUN
admet-182	81	25	)	)	PUNCT
admet-182	81	26	are	be	AUX
admet-182	81	27	accordingly	accordingly	ADV
admet-182	81	28	adjusted	adjust	VERB
admet-182	81	29	[	[	PUNCT
admet-182	81	30	9	9	NUM
admet-182	81	31	]	]	PUNCT
admet-182	81	32	.	.	PUNCT
admet-182	82	1	also	also	ADV
admet-182	82	2	,	,	PUNCT
admet-182	82	3	the	the	DET
admet-182	82	4	ph	ph	ADJ
admet-182	82	5	electrode	electrode	NOUN
admet-182	82	6	parameters	parameter	NOUN
admet-182	82	7	are	be	AUX
admet-182	82	8	adjusted	adjust	VERB
admet-182	82	9	for	for	ADP
admet-182	82	10	the	the	DET
admet-182	82	11	changing	change	VERB
admet-182	82	12	ionic	ionic	ADJ
admet-182	82	13	strength	strength	NOUN
admet-182	82	14	[	[	X
admet-182	82	15	9	9	NUM
admet-182	82	16	]	]	PUNCT
admet-182	82	17	.	.	PUNCT
admet-182	83	1	at	at	ADP
admet-182	83	2	the	the	DET
admet-182	83	3	end	end	NOUN
admet-182	83	4	of	of	ADP
admet-182	83	5	the	the	DET
admet-182	83	6	ph	ph	ADJ
admet-182	83	7	-	-	PUNCT
admet-182	83	8	speciation	speciation	NOUN
admet-182	83	9	simulation	simulation	NOUN
admet-182	83	10	,	,	PUNCT
admet-182	83	11	the	the	DET
admet-182	83	12	calculated	calculate	VERB
admet-182	83	13	log	log	NOUN
admet-182	83	14	s	s	PART
admet-182	83	15	vs.	vs.	X
admet-182	83	16	ph	ph	NOUN
admet-182	83	17	curve	curve	NOUN
admet-182	83	18	is	be	AUX
admet-182	83	19	compared	compare	VERB
admet-182	83	20	to	to	AUX
admet-182	83	21	measured	measure	VERB
admet-182	83	22	log	log	PROPN
admet-182	83	23	s	s	PROPN
admet-182	83	24	vs.	vs.	X
admet-182	83	25	ph	ph	PROPN
admet-182	83	26	.	.	PUNCT
admet-182	84	1	a	a	DET
admet-182	84	2	log	log	NOUN
admet-182	84	3	s	s	NOUN
admet-182	84	4	-	-	PUNCT
admet-182	84	5	weighted	weight	VERB
admet-182	84	6	nonlinear	nonlinear	ADJ
admet-182	84	7	least	least	ADJ
admet-182	84	8	squares	square	NOUN
admet-182	84	9	refinement	refinement	NOUN
admet-182	84	10	commences	commence	NOUN
admet-182	84	11	to	to	PART
admet-182	84	12	refine	refine	VERB
admet-182	84	13	the	the	DET
admet-182	84	14	proposed	propose	VERB
admet-182	84	15	equilibrium	equilibrium	NOUN
admet-182	84	16	model	model	NOUN
admet-182	84	17	,	,	PUNCT
admet-182	84	18	using	use	VERB
admet-182	84	19	analytical	analytical	ADJ
admet-182	84	20	expressions	expression	NOUN
admet-182	84	21	for	for	ADP
admet-182	84	22	the	the	DET
admet-182	84	23	differential	differential	ADJ
admet-182	84	24	equations	equation	NOUN
admet-182	84	25	.	.	PUNCT
admet-182	85	1	the	the	DET
admet-182	85	2	process	process	NOUN
admet-182	85	3	is	be	AUX
admet-182	85	4	repeated	repeat	VERB
admet-182	85	5	until	until	SCONJ
admet-182	85	6	the	the	DET
admet-182	85	7	differences	difference	NOUN
admet-182	85	8	between	between	ADP
admet-182	85	9	calculated	calculate	VERB
admet-182	85	10	and	and	CCONJ
admet-182	85	11	measured	measure	VERB
admet-182	85	12	log	log	NOUN
admet-182	85	13	s	s	PART
admet-182	85	14	values	value	NOUN
admet-182	85	15	reach	reach	VERB
admet-182	85	16	a	a	DET
admet-182	85	17	stable	stable	ADJ
admet-182	85	18	minimum	minimum	NOUN
admet-182	85	19	,	,	PUNCT
admet-182	85	20	as	as	SCONJ
admet-182	85	21	described	describe	VERB
admet-182	85	22	elsewhere	elsewhere	ADV
admet-182	85	23	in	in	ADP
admet-182	85	24	detail	detail	NOUN
admet-182	85	25	[	[	X
admet-182	85	26	9,18	9,18	X
admet-182	85	27	]	]	PUNCT
admet-182	85	28	.	.	PUNCT
admet-182	86	1	results	result	NOUN
admet-182	86	2	and	and	CCONJ
admet-182	86	3	discussion	discussion	VERB
admet-182	86	4	the	the	DET
admet-182	86	5	aqueous	aqueous	ADJ
admet-182	86	6	pka	pka	PROPN
admet-182	86	7	value	value	NOUN
admet-182	86	8	was	be	AUX
admet-182	86	9	determined	determine	VERB
admet-182	86	10	by	by	ADP
admet-182	86	11	yasuda	yasuda	NOUN
admet-182	86	12	-	-	PUNCT
admet-182	86	13	shedlovsky	shedlovsky	ADJ
admet-182	86	14	extrapolation	extrapolation	NOUN
admet-182	86	15	to	to	PART
admet-182	86	16	be	be	AUX
admet-182	86	17	3.76	3.76	NUM
admet-182	86	18	±	±	NUM
admet-182	86	19	0.03	0.03	NUM
admet-182	86	20	.	.	PUNCT
admet-182	87	1	figure	figure	NOUN
admet-182	87	2	2a	2a	PROPN
admet-182	87	3	shows	show	VERB
admet-182	87	4	the	the	DET
admet-182	87	5	yasuda	yasuda	NOUN
admet-182	87	6	-	-	PUNCT
admet-182	87	7	shedlovsky	shedlovsky	ADJ
admet-182	87	8	plot	plot	NOUN
admet-182	87	9	of	of	ADP
admet-182	87	10	pska	pska	NOUN
admet-182	87	11	+	+	CCONJ
admet-182	87	12	log	log	NOUN
admet-182	87	13	[	[	X
admet-182	87	14	h2o	h2o	X
admet-182	87	15	]	]	X
admet-182	87	16	vs.	vs.	ADP
admet-182	87	17	1000	1000	NUM
admet-182	87	18	/	/	SYM
admet-182	87	19	dielectric	dielectric	NOUN
admet-182	87	20	constant	constant	ADJ
admet-182	87	21	.	.	PUNCT
admet-182	88	1	the	the	DET
admet-182	88	2	spectra	spectra	NOUN
admet-182	88	3	measured	measure	VERB
admet-182	88	4	during	during	ADP
admet-182	88	5	titration	titration	NOUN
admet-182	88	6	in	in	ADP
admet-182	88	7	40.9	40.9	NUM
admet-182	88	8	%	%	NOUN
admet-182	88	9	methanol	methanol	NOUN
admet-182	88	10	are	be	AUX
admet-182	88	11	shown	show	VERB
admet-182	88	12	in	in	ADP
admet-182	88	13	figure	figure	NOUN
admet-182	88	14	2b	2b	NOUN
admet-182	88	15	.	.	PUNCT
admet-182	89	1	each	each	DET
admet-182	89	2	line	line	NOUN
admet-182	89	3	represents	represent	VERB
admet-182	89	4	a	a	DET
admet-182	89	5	spectrum	spectrum	NOUN
admet-182	89	6	measured	measure	VERB
admet-182	89	7	at	at	ADP
admet-182	89	8	a	a	DET
admet-182	89	9	particular	particular	ADJ
admet-182	89	10	ph	ph	NOUN
admet-182	89	11	between	between	ADP
admet-182	89	12	1.5	1.5	NUM
admet-182	89	13	and	and	CCONJ
admet-182	89	14	5.2	5.2	NUM
admet-182	89	15	.	.	PUNCT
admet-182	90	1	figure	figure	NOUN
admet-182	90	2	2	2	NUM
admet-182	90	3	.	.	PUNCT
admet-182	91	1	(	(	PUNCT
admet-182	91	2	a	a	X
admet-182	91	3	)	)	PUNCT
admet-182	91	4	yasuda	yasuda	NOUN
admet-182	91	5	-	-	PUNCT
admet-182	91	6	shedlovsky	shedlovsky	ADJ
admet-182	91	7	extrapolation	extrapolation	NOUN
admet-182	91	8	of	of	ADP
admet-182	91	9	pska	pska	NOUN
admet-182	91	10	(	(	PUNCT
admet-182	91	11	+	+	CCONJ
admet-182	91	12	log	log	NOUN
admet-182	91	13	[	[	X
admet-182	91	14	h2o	h2o	X
admet-182	91	15	]	]	PUNCT
admet-182	91	16	)	)	PUNCT
admet-182	91	17	at	at	ADP
admet-182	91	18	three	three	NUM
admet-182	91	19	ratios	ratio	NOUN
admet-182	91	20	of	of	ADP
admet-182	91	21	methanol	methanol	NOUN
admet-182	91	22	to	to	ADP
admet-182	91	23	water	water	NOUN
admet-182	91	24	.	.	PUNCT
admet-182	92	1	aqueous	aqueous	PROPN
admet-182	92	2	pka	pka	PROPN
admet-182	92	3	determined	determine	VERB
admet-182	92	4	from	from	ADP
admet-182	92	5	intercept	intercept	NOUN
admet-182	92	6	with	with	ADP
admet-182	92	7	vertical	vertical	ADJ
admet-182	92	8	red	red	ADJ
admet-182	92	9	line	line	NOUN
admet-182	92	10	,	,	PUNCT
admet-182	92	11	equivalent	equivalent	ADJ
admet-182	92	12	to	to	ADP
admet-182	92	13	1000	1000	NUM
admet-182	92	14	/	/	SYM
admet-182	92	15	dielectric	dielectric	NOUN
admet-182	92	16	constant	constant	ADJ
admet-182	92	17	for	for	ADP
admet-182	92	18	water	water	NOUN
admet-182	92	19	,	,	PUNCT
admet-182	92	20	minus	minus	CCONJ
admet-182	92	21	the	the	DET
admet-182	92	22	log	log	NOUN
admet-182	92	23	[	[	X
admet-182	92	24	h2o	h2o	X
admet-182	92	25	]	]	PUNCT
admet-182	92	26	.	.	PUNCT
admet-182	93	1	(	(	PUNCT
admet-182	93	2	b	b	X
admet-182	93	3	)	)	PUNCT
admet-182	93	4	spectra	spectra	NOUN
admet-182	93	5	measured	measure	VERB
admet-182	93	6	during	during	ADP
admet-182	93	7	titration	titration	NOUN
admet-182	93	8	in	in	ADP
admet-182	93	9	40.9	40.9	NUM
admet-182	93	10	%	%	NOUN
admet-182	93	11	methanol	methanol	NOUN
admet-182	93	12	.	.	PUNCT
admet-182	94	1	each	each	DET
admet-182	94	2	line	line	NOUN
admet-182	94	3	represents	represent	VERB
admet-182	94	4	spectrum	spectrum	NOUN
admet-182	94	5	measured	measure	VERB
admet-182	94	6	at	at	ADP
admet-182	94	7	a	a	DET
admet-182	94	8	different	different	ADJ
admet-182	94	9	ph	ph	NOUN
admet-182	94	10	between	between	ADP
admet-182	94	11	1.5	1.5	NUM
admet-182	94	12	and	and	CCONJ
admet-182	94	13	5.2	5.2	NUM
admet-182	94	14	.	.	PUNCT
admet-182	95	1	the	the	DET
admet-182	95	2	pka	pka	PROPN
admet-182	95	3	results	result	NOUN
admet-182	95	4	and	and	CCONJ
admet-182	95	5	those	those	PRON
admet-182	95	6	of	of	ADP
admet-182	95	7	the	the	DET
admet-182	95	8	re	re	NOUN
admet-182	95	9	-	-	NOUN
admet-182	95	10	analysis	analysis	VERB
admet-182	95	11	the	the	DET
admet-182	95	12	ran	ran	NOUN
admet-182	95	13	et	et	PROPN
admet-182	95	14	al	al	PROPN
admet-182	95	15	.	.	PUNCT
admet-182	96	1	[	[	X
admet-182	96	2	16	16	NUM
admet-182	96	3	]	]	PUNCT
admet-182	96	4	and	and	CCONJ
admet-182	96	5	jain	jain	PROPN
admet-182	96	6	et	et	PROPN
admet-182	96	7	al	al	PROPN
admet-182	96	8	.	.	PUNCT
admet-182	97	1	[	[	X
admet-182	97	2	17	17	NUM
admet-182	97	3	]	]	PUNCT
admet-182	97	4	solubility	solubility	NOUN
admet-182	97	5	-	-	PUNCT
admet-182	97	6	ph	ph	NOUN
admet-182	97	7	data	datum	NOUN
admet-182	97	8	are	be	AUX
admet-182	97	9	summarized	summarize	VERB
admet-182	97	10	in	in	ADP
admet-182	97	11	table	table	NOUN
admet-182	97	12	1	1	NUM
admet-182	97	13	.	.	PUNCT
admet-182	98	1	(	(	PUNCT
admet-182	98	2	a	a	PRON
admet-182	98	3	)	)	PUNCT
admet-182	98	4	nsc-637829	nsc-637829	NOUN
admet-182	98	5	y	y	PROPN
admet-182	98	6	-	-	PUNCT
admet-182	98	7	s	s	PART
admet-182	98	8	extrapolation	extrapolation	NOUN
admet-182	98	9	14	14	NUM
admet-182	98	10	16	16	NUM
admet-182	98	11	18	18	NUM
admet-182	98	12	20	20	NUM
admet-182	98	13	1000	1000	NUM
admet-182	98	14	/	/	SYM
admet-182	98	15	dielectric	dielectric	ADJ
admet-182	98	16	constant	constant	ADJ
admet-182	98	17	3	3	NUM
admet-182	98	18	4	4	NUM
admet-182	98	19	5	5	NUM
admet-182	98	20	p	p	NOUN
admet-182	98	21	s	s	PART
admet-182	98	22	k	k	PROPN
admet-182	98	23	a	a	X
admet-182	98	24	+	+	X
admet-182	99	1	l	l	NOUN
admet-182	99	2	o	o	X
admet-182	99	3	g	g	NOUN
admet-182	99	4	[	[	PUNCT
admet-182	99	5	h	h	NOUN
admet-182	99	6	2	2	NUM
admet-182	99	7	o	o	NOUN
admet-182	99	8	]	]	X
admet-182	99	9	(	(	PUNCT
admet-182	99	10	b	b	NOUN
admet-182	99	11	)	)	PUNCT
admet-182	99	12	nsc-637829	nsc-637829	NOUN
admet-182	99	13	spectra	spectra	NOUN
admet-182	99	14	300	300	NUM
admet-182	99	15	400	400	NUM
admet-182	99	16	wavelength	wavelength	NOUN
admet-182	99	17	(	(	PUNCT
admet-182	99	18	nm	nm	NOUN
admet-182	99	19	)	)	PUNCT
admet-182	99	20	0.0	0.0	NUM
admet-182	99	21	0.2	0.2	NUM
admet-182	99	22	0.4	0.4	NUM
admet-182	99	23	a	a	DET
admet-182	99	24	b	b	PROPN
admet-182	99	25	s	s	PART
admet-182	99	26	o	o	NOUN
admet-182	99	27	rb	rb	NOUN
admet-182	99	28	a	a	PRON
admet-182	99	29	n	n	NOUN
admet-182	99	30	c	c	NOUN
admet-182	99	31	ey	ey	X
admet-182	99	32	=	=	SYM
admet-182	99	33	-0.386x	-0.386x	PROPN
admet-182	99	34	+	+	NUM
admet-182	99	35	10.42	10.42	NUM
admet-182	99	36	admet	admet	X
admet-182	99	37	&	&	CCONJ
admet-182	99	38	dmpk	dmpk	PROPN
admet-182	99	39	3(2	3(2	NUM
admet-182	99	40	)	)	PUNCT
admet-182	99	41	(	(	PUNCT
admet-182	99	42	2015	2015	NUM
admet-182	99	43	)	)	PUNCT
admet-182	99	44	131	131	NUM
admet-182	99	45	-	-	SYM
admet-182	99	46	140	140	NUM
admet-182	99	47	pka	pka	NOUN
admet-182	99	48	-	-	PUNCT
admet-182	99	49	critical	critical	ADJ
admet-182	99	50	interpretations	interpretation	NOUN
admet-182	99	51	of	of	ADP
admet-182	99	52	solubility	solubility	NOUN
admet-182	99	53	-	-	PUNCT
admet-182	99	54	ph	ph	ADJ
admet-182	99	55	profiles	profile	NOUN
admet-182	99	56	doi	doi	NOUN
admet-182	99	57	:	:	PUNCT
admet-182	99	58	10.5599	10.5599	NUM
admet-182	99	59	/	/	SYM
admet-182	99	60	admet.3.2.182	admet.3.2.182	NOUN
admet-182	99	61	135	135	NUM
admet-182	99	62	table	table	NOUN
admet-182	99	63	1	1	NUM
admet-182	99	64	.	.	PUNCT
admet-182	100	1	summary	summary	NOUN
admet-182	100	2	of	of	ADP
admet-182	100	3	the	the	DET
admet-182	100	4	results	result	NOUN
admet-182	100	5	of	of	ADP
admet-182	100	6	the	the	DET
admet-182	100	7	re	re	NOUN
admet-182	100	8	-	-	NOUN
admet-182	100	9	analysis	analysis	NOUN
admet-182	100	10	of	of	ADP
admet-182	100	11	the	the	DET
admet-182	100	12	pg-300995	pg-300995	NOUN
admet-182	100	13	[	[	X
admet-182	100	14	16	16	NUM
admet-182	100	15	]	]	PUNCT
admet-182	100	16	and	and	CCONJ
admet-182	100	17	nsc-639829	nsc-639829	NOUN
admet-182	101	1	[	[	X
admet-182	101	2	17	17	NUM
admet-182	101	3	]	]	PUNCT
admet-182	101	4	data	datum	NOUN
admet-182	101	5	.	.	PUNCT
admet-182	102	1	a	a	DET
admet-182	102	2	pka	pka	PROPN
admet-182	102	3	values	value	NOUN
admet-182	102	4	predicted	predict	VERB
admet-182	102	5	by	by	ADP
admet-182	102	6	marvinsketch	marvinsketch	PROPN
admet-182	102	7	(	(	PUNCT
admet-182	102	8	chemaxon	chemaxon	NOUN
admet-182	102	9	)	)	PUNCT
admet-182	102	10	.	.	PUNCT
admet-182	103	1	underlined	underline	VERB
admet-182	103	2	values	value	NOUN
admet-182	103	3	refers	refer	VERB
admet-182	103	4	to	to	ADP
admet-182	103	5	acidic	acidic	ADJ
admet-182	103	6	group	group	NOUN
admet-182	103	7	ionization	ionization	NOUN
admet-182	103	8	;	;	PUNCT
admet-182	103	9	otherwise	otherwise	ADV
admet-182	103	10	,	,	PUNCT
admet-182	103	11	the	the	DET
admet-182	103	12	value	value	NOUN
admet-182	103	13	is	be	AUX
admet-182	103	14	that	that	PRON
admet-182	103	15	of	of	ADP
admet-182	103	16	basic	basic	ADJ
admet-182	103	17	group	group	NOUN
admet-182	103	18	ionization	ionization	NOUN
admet-182	103	19	.	.	PUNCT
admet-182	104	1	b	b	X
admet-182	104	2	refined	refined	ADJ
admet-182	104	3	pka	pka	PROPN
admet-182	104	4	by	by	ADP
admet-182	104	5	the	the	DET
admet-182	104	6	sph	sph	PROPN
admet-182	104	7	-	-	PUNCT
admet-182	104	8	pka	pka	PROPN
admet-182	104	9	method	method	NOUN
admet-182	104	10	.	.	PUNCT
admet-182	105	1	c	c	PROPN
admet-182	105	2	measured	measure	VERB
admet-182	105	3	pka	pka	PROPN
admet-182	105	4	by	by	ADP
admet-182	105	5	uv	uv	NOUN
admet-182	105	6	cosolvent	cosolvent	ADJ
admet-182	105	7	extrapolation	extrapolation	NOUN
admet-182	105	8	from	from	ADP
admet-182	105	9	21.6	21.6	NUM
admet-182	105	10	-	-	SYM
admet-182	105	11	40.9	40.9	NUM
admet-182	105	12	%	%	NOUN
admet-182	105	13	w	w	PROPN
admet-182	105	14	/	/	SYM
admet-182	105	15	w	w	NOUN
admet-182	105	16	ch3oh	ch3oh	ADV
admet-182	105	17	-	-	PUNCT
admet-182	105	18	h2o	h2o	NOUN
admet-182	105	19	(	(	PUNCT
admet-182	105	20	this	this	DET
admet-182	105	21	work	work	NOUN
admet-182	105	22	)	)	PUNCT
admet-182	105	23	.	.	PUNCT
admet-182	106	1	d	d	X
admet-182	106	2	s0	s0	NOUN
admet-182	106	3	=	=	SYM
admet-182	106	4	intrinsic	intrinsic	ADJ
admet-182	106	5	solubility	solubility	NOUN
admet-182	106	6	(	(	PUNCT
admet-182	106	7	this	this	DET
admet-182	106	8	work	work	NOUN
admet-182	106	9	)	)	PUNCT
admet-182	106	10	.	.	PUNCT
admet-182	107	1	e	e	X
admet-182	107	2	gof	gof	NOUN
admet-182	107	3	=	=	SYM
admet-182	107	4	goodness	goodness	NOUN
admet-182	107	5	-	-	PUNCT
admet-182	107	6	of	of	ADP
admet-182	107	7	-	-	PUNCT
admet-182	107	8	fit	fit	NOUN
admet-182	107	9	[	[	X
admet-182	107	10	9,18	9,18	NUM
admet-182	107	11	]	]	PUNCT
admet-182	107	12	.	.	PUNCT
admet-182	108	1	f	f	PROPN
admet-182	108	2	not	not	PART
admet-182	108	3	determined	determine	VERB
admet-182	108	4	.	.	PUNCT
admet-182	109	1	g	g	PROPN
admet-182	109	2	acidic	acidic	ADJ
admet-182	109	3	pka	pka	PROPN
admet-182	109	4	not	not	PART
admet-182	109	5	found	find	VERB
admet-182	109	6	experimentally	experimentally	ADV
admet-182	109	7	below	below	ADP
admet-182	109	8	ph	ph	PROPN
admet-182	109	9	12	12	NUM
admet-182	109	10	in	in	ADP
admet-182	109	11	fig.3b	fig.3b	NUM
admet-182	109	12	.	.	PUNCT
admet-182	110	1	also	also	ADV
admet-182	110	2	,	,	PUNCT
admet-182	110	3	preliminary	preliminary	ADJ
admet-182	110	4	uv	uv	PROPN
admet-182	110	5	pka	pka	PROPN
admet-182	110	6	assay	assay	ADV
admet-182	110	7	from	from	ADP
admet-182	110	8	ph	ph	PROPN
admet-182	110	9	2	2	NUM
admet-182	110	10	–	–	PUNCT
admet-182	110	11	12	12	NUM
admet-182	110	12	indicated	indicate	VERB
admet-182	110	13	no	no	DET
admet-182	110	14	additional	additional	ADJ
admet-182	110	15	pkas	pkas	NOUN
admet-182	110	16	within	within	ADP
admet-182	110	17	the	the	DET
admet-182	110	18	range	range	NOUN
admet-182	110	19	.	.	PUNCT
admet-182	111	1	pg-300995	pg-300995	PROPN
admet-182	111	2	pka	pka	PROPN
admet-182	111	3	and	and	CCONJ
admet-182	111	4	s0	s0	PROPN
admet-182	111	5	the	the	DET
admet-182	111	6	two	two	NUM
admet-182	111	7	marvinsketch	marvinsketch	NOUN
admet-182	111	8	-	-	PUNCT
admet-182	111	9	predicted	predict	VERB
admet-182	111	10	pkas	pkas	NOUN
admet-182	111	11	for	for	ADP
admet-182	111	12	pg-300995	pg-300995	PROPN
admet-182	111	13	are	be	AUX
admet-182	111	14	3.52	3.52	NUM
admet-182	111	15	(	(	PUNCT
admet-182	111	16	benzimidazole	benzimidazole	PROPN
admet-182	111	17	–	–	PUNCT
admet-182	111	18	n=	n=	ADJ
admet-182	111	19	basic	basic	ADJ
admet-182	111	20	functionality	functionality	NOUN
admet-182	111	21	)	)	PUNCT
admet-182	111	22	and	and	CCONJ
admet-182	111	23	10.58	10.58	NUM
admet-182	111	24	(	(	PUNCT
admet-182	111	25	–	–	PUNCT
admet-182	111	26	nhacidic	nhacidic	ADJ
admet-182	111	27	group	group	NOUN
admet-182	111	28	)	)	PUNCT
admet-182	111	29	.	.	PUNCT
admet-182	112	1	the	the	DET
admet-182	112	2	corresponding	corresponding	ADJ
admet-182	112	3	amine	amine	ADJ
admet-182	112	4	pka	pka	PROPN
admet-182	112	5	from	from	ADP
admet-182	112	6	admet	admet	PROPN
admet-182	112	7	predictor	predictor	PROPN
admet-182	112	8	(	(	PUNCT
admet-182	112	9	average	average	ADJ
admet-182	112	10	over	over	ADP
admet-182	112	11	2	2	NUM
admet-182	112	12	tautomers	tautomer	NOUN
admet-182	112	13	)	)	PUNCT
admet-182	112	14	was	be	AUX
admet-182	112	15	3.60	3.60	NUM
admet-182	112	16	,	,	PUNCT
admet-182	112	17	in	in	ADP
admet-182	112	18	close	close	ADJ
admet-182	112	19	agreement	agreement	NOUN
admet-182	112	20	with	with	ADP
admet-182	112	21	that	that	PRON
admet-182	112	22	of	of	ADP
admet-182	112	23	marvinsketch	marvinsketch	PROPN
admet-182	112	24	.	.	PUNCT
admet-182	113	1	however	however	ADV
admet-182	113	2	,	,	PUNCT
admet-182	113	3	the	the	DET
admet-182	113	4	value	value	NOUN
admet-182	113	5	from	from	ADP
admet-182	113	6	acd	acd	NOUN
admet-182	113	7	/	/	SYM
admet-182	113	8	percepta	percepta	NOUN
admet-182	113	9	,	,	PUNCT
admet-182	113	10	5.30	5.30	NUM
admet-182	113	11	,	,	PUNCT
admet-182	113	12	was	be	AUX
admet-182	113	13	less	less	ADV
admet-182	113	14	concordant	concordant	ADJ
admet-182	113	15	.	.	PUNCT
admet-182	114	1	the	the	DET
admet-182	114	2	refined	refine	VERB
admet-182	114	3	sph	sph	PROPN
admet-182	114	4	-	-	PUNCT
admet-182	114	5	pka	pka	PROPN
admet-182	114	6	is	be	AUX
admet-182	114	7	3.61	3.61	NUM
admet-182	114	8	±	±	NUM
admet-182	114	9	0.06	0.06	NUM
admet-182	114	10	,	,	PUNCT
admet-182	114	11	indicated	indicate	VERB
admet-182	114	12	by	by	ADP
admet-182	114	13	the	the	DET
admet-182	114	14	ph	ph	NOUN
admet-182	114	15	in	in	ADP
admet-182	114	16	the	the	DET
admet-182	114	17	bend	bend	NOUN
admet-182	114	18	in	in	ADP
admet-182	114	19	the	the	DET
admet-182	114	20	log	log	NOUN
admet-182	114	21	s	s	NOUN
admet-182	114	22	ph	ph	NOUN
admet-182	114	23	curve	curve	NOUN
admet-182	114	24	in	in	ADP
admet-182	114	25	figure	figure	NOUN
admet-182	114	26	3a	3a	NUM
admet-182	114	27	,	,	PUNCT
admet-182	114	28	agrees	agree	VERB
admet-182	114	29	very	very	ADV
admet-182	114	30	well	well	ADV
admet-182	114	31	with	with	ADP
admet-182	114	32	the	the	DET
admet-182	114	33	predictions	prediction	NOUN
admet-182	114	34	from	from	ADP
admet-182	114	35	two	two	NUM
admet-182	114	36	of	of	ADP
admet-182	114	37	the	the	DET
admet-182	114	38	commercial	commercial	ADJ
admet-182	114	39	programs	program	NOUN
admet-182	114	40	.	.	PUNCT
admet-182	115	1	there	there	PRON
admet-182	115	2	is	be	VERB
admet-182	115	3	no	no	DET
admet-182	115	4	indication	indication	NOUN
admet-182	115	5	of	of	ADP
admet-182	115	6	the	the	DET
admet-182	115	7	acidic	acidic	ADJ
admet-182	115	8	ionization	ionization	NOUN
admet-182	115	9	in	in	ADP
admet-182	115	10	the	the	DET
admet-182	115	11	solubility	solubility	NOUN
admet-182	115	12	profile	profile	NOUN
admet-182	115	13	,	,	PUNCT
admet-182	115	14	suggesting	suggest	VERB
admet-182	115	15	that	that	SCONJ
admet-182	115	16	the	the	DET
admet-182	115	17	second	second	ADJ
admet-182	115	18	pka	pka	PROPN
admet-182	115	19	must	must	AUX
admet-182	115	20	be	be	AUX
admet-182	115	21	greater	great	ADJ
admet-182	115	22	than	than	ADP
admet-182	115	23	9	9	NUM
admet-182	115	24	,	,	PUNCT
admet-182	115	25	which	which	PRON
admet-182	115	26	is	be	AUX
admet-182	115	27	consistent	consistent	ADJ
admet-182	115	28	with	with	ADP
admet-182	115	29	the	the	DET
admet-182	115	30	predicted	predict	VERB
admet-182	115	31	value	value	NOUN
admet-182	115	32	from	from	ADP
admet-182	115	33	all	all	DET
admet-182	115	34	three	three	NUM
admet-182	115	35	pka	pka	NOUN
admet-182	115	36	prediction	prediction	NOUN
admet-182	115	37	programs	program	NOUN
admet-182	115	38	.	.	PUNCT
admet-182	116	1	since	since	SCONJ
admet-182	116	2	the	the	DET
admet-182	116	3	molecule	molecule	NOUN
admet-182	116	4	is	be	AUX
admet-182	116	5	relatively	relatively	ADV
admet-182	116	6	simple	simple	ADJ
admet-182	116	7	and	and	CCONJ
admet-182	116	8	not	not	PART
admet-182	116	9	too	too	ADV
admet-182	116	10	insoluble	insoluble	ADJ
admet-182	116	11	,	,	PUNCT
admet-182	116	12	and	and	CCONJ
admet-182	116	13	since	since	SCONJ
admet-182	116	14	the	the	DET
admet-182	116	15	predicted	predict	VERB
admet-182	116	16	basic	basic	ADJ
admet-182	116	17	pka	pka	PROPN
admet-182	116	18	agrees	agree	VERB
admet-182	116	19	with	with	ADP
admet-182	116	20	the	the	DET
admet-182	116	21	measured	measure	VERB
admet-182	116	22	value	value	NOUN
admet-182	116	23	,	,	PUNCT
admet-182	116	24	the	the	DET
admet-182	116	25	refined	refine	VERB
admet-182	116	26	sph	sph	PROPN
admet-182	116	27	-	-	PUNCT
admet-182	116	28	pka	pka	PROPN
admet-182	116	29	tentatively	tentatively	ADV
admet-182	116	30	was	be	AUX
admet-182	116	31	taken	take	VERB
admet-182	116	32	to	to	PART
admet-182	116	33	be	be	AUX
admet-182	116	34	a	a	DET
admet-182	116	35	measure	measure	NOUN
admet-182	116	36	of	of	ADP
admet-182	116	37	the	the	DET
admet-182	116	38	true	true	ADJ
admet-182	116	39	pka	pka	PROPN
admet-182	116	40	.	.	PUNCT
admet-182	117	1	thus	thus	ADV
admet-182	117	2	,	,	PUNCT
admet-182	117	3	the	the	DET
admet-182	117	4	henderson	henderson	PROPN
admet-182	117	5	-	-	PUNCT
admet-182	117	6	hasselbalch	hasselbalch	PROPN
admet-182	117	7	equation	equation	NOUN
admet-182	117	8	is	be	AUX
admet-182	117	9	thought	think	VERB
admet-182	117	10	to	to	PART
admet-182	117	11	be	be	AUX
admet-182	117	12	a	a	DET
admet-182	117	13	valid	valid	ADJ
admet-182	117	14	description	description	NOUN
admet-182	117	15	of	of	ADP
admet-182	117	16	the	the	DET
admet-182	117	17	solubility	solubility	NOUN
admet-182	117	18	-	-	PUNCT
admet-182	117	19	ph	ph	NOUN
admet-182	117	20	curve	curve	NOUN
admet-182	117	21	.	.	PUNCT
admet-182	118	1	this	this	PRON
admet-182	118	2	is	be	AUX
admet-182	118	3	,	,	PUNCT
admet-182	118	4	of	of	ADP
admet-182	118	5	course	course	NOUN
admet-182	118	6	,	,	PUNCT
admet-182	118	7	a	a	DET
admet-182	118	8	tentative	tentative	ADJ
admet-182	118	9	assignment	assignment	NOUN
admet-182	118	10	,	,	PUNCT
admet-182	118	11	since	since	SCONJ
admet-182	118	12	the	the	DET
admet-182	118	13	independently	independently	ADV
admet-182	118	14	measured	measure	VERB
admet-182	118	15	value	value	NOUN
admet-182	118	16	of	of	ADP
admet-182	118	17	the	the	DET
admet-182	118	18	pka	pka	NOUN
admet-182	118	19	of	of	ADP
admet-182	118	20	pg-300995	pg-300995	PROPN
admet-182	118	21	is	be	AUX
admet-182	118	22	not	not	PART
admet-182	118	23	available	available	ADJ
admet-182	118	24	.	.	PUNCT
admet-182	119	1	the	the	DET
admet-182	119	2	refined	refined	ADJ
admet-182	119	3	intrinsic	intrinsic	ADJ
admet-182	119	4	solubility	solubility	NOUN
admet-182	119	5	,	,	PUNCT
admet-182	119	6	s0	s0	PROPN
admet-182	119	7	=	=	PUNCT
admet-182	119	8	51.3	51.3	NUM
admet-182	119	9	±	±	NUM
admet-182	119	10	0.7	0.7	NUM
admet-182	119	11	μg	μg	NOUN
admet-182	119	12	/	/	SYM
admet-182	119	13	ml	ml	PROPN
admet-182	119	14	,	,	PUNCT
admet-182	119	15	agrees	agree	VERB
admet-182	119	16	well	well	ADV
admet-182	119	17	with	with	ADP
admet-182	119	18	the	the	DET
admet-182	119	19	reported	report	VERB
admet-182	119	20	value	value	NOUN
admet-182	119	21	[	[	X
admet-182	119	22	16	16	NUM
admet-182	119	23	]	]	PUNCT
admet-182	119	24	.	.	PUNCT
admet-182	120	1	each	each	DET
admet-182	120	2	point	point	NOUN
admet-182	120	3	in	in	ADP
admet-182	120	4	figure	figure	NOUN
admet-182	120	5	3a	3a	NUM
admet-182	120	6	was	be	AUX
admet-182	120	7	assigned	assign	VERB
admet-182	120	8	the	the	DET
admet-182	120	9	standard	standard	ADJ
admet-182	120	10	deviation	deviation	NOUN
admet-182	120	11	of	of	ADP
admet-182	120	12	0.1	0.1	NUM
admet-182	120	13	(	(	PUNCT
admet-182	120	14	not	not	PART
admet-182	120	15	reported	report	VERB
admet-182	120	16	in	in	ADP
admet-182	120	17	the	the	DET
admet-182	120	18	original	original	ADJ
admet-182	120	19	publication	publication	NOUN
admet-182	120	20	)	)	PUNCT
admet-182	120	21	.	.	PUNCT
admet-182	121	1	the	the	DET
admet-182	121	2	overall	overall	ADJ
admet-182	121	3	goodness	goodness	NOUN
admet-182	121	4	-	-	PUNCT
admet-182	121	5	of	of	ADP
admet-182	121	6	-	-	PUNCT
admet-182	121	7	fit	fit	NOUN
admet-182	121	8	,	,	PUNCT
admet-182	121	9	gof	gof	NOUN
admet-182	121	10	=	=	PROPN
admet-182	121	11	0.77	0.77	NUM
admet-182	121	12	,	,	PUNCT
admet-182	121	13	suggests	suggest	VERB
admet-182	121	14	that	that	SCONJ
admet-182	121	15	the	the	DET
admet-182	121	16	points	point	NOUN
admet-182	121	17	are	be	AUX
admet-182	121	18	scattered	scatter	VERB
admet-182	121	19	by	by	ADP
admet-182	121	20	0.077	0.077	NUM
admet-182	121	21	log	log	PROPN
admet-182	121	22	units	unit	NOUN
admet-182	121	23	about	about	ADP
admet-182	121	24	the	the	DET
admet-182	121	25	best	good	ADJ
admet-182	121	26	-	-	PUNCT
admet-182	121	27	fit	fit	NOUN
admet-182	121	28	curve	curve	NOUN
admet-182	121	29	.	.	PUNCT
admet-182	122	1	nsc-639829	nsc-639829	PROPN
admet-182	123	1	pka	pka	PROPN
admet-182	123	2	the	the	DET
admet-182	123	3	two	two	NUM
admet-182	123	4	marvinsketch	marvinsketch	NOUN
admet-182	123	5	-	-	PUNCT
admet-182	123	6	predicted	predict	VERB
admet-182	123	7	pkas	pkas	NOUN
admet-182	123	8	for	for	ADP
admet-182	123	9	nsc-639829	nsc-639829	NOUN
admet-182	123	10	were	be	AUX
admet-182	123	11	far	far	ADV
admet-182	123	12	from	from	ADP
admet-182	123	13	what	what	PRON
admet-182	123	14	was	be	AUX
admet-182	123	15	indicated	indicate	VERB
admet-182	123	16	in	in	ADP
admet-182	123	17	figure	figure	NOUN
admet-182	123	18	3b	3b	NUM
admet-182	123	19	.	.	PUNCT
admet-182	124	1	it	it	PRON
admet-182	124	2	is	be	AUX
admet-182	124	3	quite	quite	ADV
admet-182	124	4	clear	clear	ADJ
admet-182	124	5	that	that	SCONJ
admet-182	124	6	there	there	PRON
admet-182	124	7	is	be	VERB
admet-182	124	8	no	no	DET
admet-182	124	9	acidic	acidic	ADJ
admet-182	124	10	ionization	ionization	NOUN
admet-182	124	11	corresponding	correspond	VERB
admet-182	124	12	to	to	ADP
admet-182	124	13	the	the	DET
admet-182	124	14	urea	urea	PROPN
admet-182	124	15	nh	nh	PROPN
admet-182	124	16	group	group	NOUN
admet-182	124	17	below	below	ADP
admet-182	124	18	ph	ph	PROPN
admet-182	124	19	12	12	NUM
admet-182	124	20	.	.	PUNCT
admet-182	125	1	this	this	PRON
admet-182	125	2	was	be	AUX
admet-182	125	3	also	also	ADV
admet-182	125	4	the	the	DET
admet-182	125	5	finding	finding	NOUN
admet-182	125	6	of	of	ADP
admet-182	125	7	the	the	DET
admet-182	125	8	spectrophotometric	spectrophotometric	ADJ
admet-182	125	9	pka	pka	PROPN
admet-182	125	10	determination	determination	NOUN
admet-182	125	11	.	.	PUNCT
admet-182	126	1	the	the	DET
admet-182	126	2	dimethylaniline	dimethylaniline	PROPN
admet-182	126	3	amine	amine	PROPN
admet-182	126	4	sphpka	sphpka	NOUN
admet-182	126	5	and	and	CCONJ
admet-182	126	6	the	the	DET
admet-182	126	7	predicted	predict	VERB
admet-182	126	8	value	value	NOUN
admet-182	126	9	(	(	PUNCT
admet-182	126	10	table	table	NOUN
admet-182	126	11	1	1	NUM
admet-182	126	12	)	)	PUNCT
admet-182	126	13	were	be	AUX
admet-182	126	14	different	different	ADJ
admet-182	126	15	by	by	ADP
admet-182	126	16	2.4	2.4	NUM
admet-182	126	17	log	log	NOUN
admet-182	126	18	units	unit	NOUN
admet-182	126	19	.	.	PUNCT
admet-182	127	1	with	with	ADP
admet-182	127	2	the	the	DET
admet-182	127	3	adage	adage	NOUN
admet-182	127	4	“	"	PUNCT
admet-182	127	5	prediction	prediction	NOUN
admet-182	127	6	guides	guide	NOUN
admet-182	127	7	but	but	CCONJ
admet-182	127	8	experiment	experiment	NOUN
admet-182	127	9	decides	decide	VERB
admet-182	127	10	,	,	PUNCT
admet-182	127	11	”	"	PUNCT
admet-182	127	12	it	it	PRON
admet-182	127	13	was	be	AUX
admet-182	127	14	decided	decide	VERB
admet-182	127	15	to	to	PART
admet-182	127	16	measure	measure	VERB
admet-182	127	17	the	the	DET
admet-182	127	18	pka(s	pka(s	PROPN
admet-182	127	19	)	)	PUNCT
admet-182	127	20	of	of	ADP
admet-182	127	21	nsc-639829	nsc-639829	NOUN
admet-182	127	22	by	by	ADP
admet-182	127	23	an	an	DET
admet-182	127	24	independent	independent	ADJ
admet-182	127	25	method	method	NOUN
admet-182	127	26	.	.	PUNCT
admet-182	128	1	one	one	NUM
admet-182	128	2	pka	pka	PROPN
admet-182	128	3	was	be	AUX
admet-182	128	4	evident	evident	ADJ
admet-182	128	5	by	by	ADP
admet-182	128	6	the	the	DET
admet-182	128	7	spectrophotometric	spectrophotometric	ADJ
admet-182	128	8	method	method	NOUN
admet-182	128	9	,	,	PUNCT
admet-182	128	10	and	and	CCONJ
admet-182	128	11	its	its	PRON
admet-182	128	12	value	value	NOUN
admet-182	128	13	was	be	AUX
admet-182	128	14	different	different	ADJ
admet-182	128	15	from	from	ADP
admet-182	128	16	both	both	CCONJ
admet-182	128	17	the	the	DET
admet-182	128	18	predicted	predict	VERB
admet-182	128	19	and	and	CCONJ
admet-182	128	20	the	the	DET
admet-182	128	21	refined	refined	ADJ
admet-182	128	22	sph	sph	PROPN
admet-182	128	23	-	-	PUNCT
admet-182	128	24	pka	pka	PROPN
admet-182	128	25	values	value	NOUN
admet-182	128	26	(	(	PUNCT
admet-182	128	27	table	table	NOUN
admet-182	128	28	1	1	NUM
admet-182	128	29	)	)	PUNCT
admet-182	128	30	.	.	PUNCT
admet-182	129	1	in	in	ADP
admet-182	129	2	depth	depth	NOUN
admet-182	129	3	analyses	analysis	NOUN
admet-182	129	4	of	of	ADP
admet-182	129	5	many	many	ADJ
admet-182	129	6	log	log	NOUN
admet-182	129	7	s	s	PART
admet-182	129	8	–	–	PUNCT
admet-182	129	9	ph	ph	ADJ
admet-182	129	10	profiles	profile	NOUN
admet-182	129	11	[	[	X
admet-182	129	12	10	10	NUM
admet-182	129	13	,	,	PUNCT
admet-182	129	14	12	12	NUM
admet-182	129	15	,	,	PUNCT
admet-182	129	16	18	18	NUM
admet-182	129	17	]	]	PUNCT
admet-182	129	18	show	show	VERB
admet-182	129	19	that	that	SCONJ
admet-182	129	20	pka	pka	PROPN
admet-182	129	21	values	value	NOUN
admet-182	129	22	determined	determine	VERB
admet-182	129	23	by	by	ADP
admet-182	129	24	modern	modern	ADJ
admet-182	129	25	purpose	purpose	NOUN
admet-182	129	26	-	-	PUNCT
admet-182	129	27	built	build	VERB
admet-182	129	28	pka	pka	NOUN
admet-182	129	29	instrumentation	instrumentation	NOUN
admet-182	129	30	[	[	X
admet-182	129	31	13	13	NUM
admet-182	129	32	,	,	PUNCT
admet-182	129	33	14	14	NUM
admet-182	129	34	]	]	PUNCT
admet-182	129	35	can	can	AUX
admet-182	129	36	differ	differ	VERB
admet-182	129	37	substantially	substantially	ADV
admet-182	129	38	from	from	ADP
admet-182	129	39	sph	sph	PROPN
admet-182	129	40	-	-	PUNCT
admet-182	129	41	pka	pka	PROPN
admet-182	129	42	values	value	NOUN
admet-182	129	43	,	,	PUNCT
admet-182	129	44	suggesting	suggest	VERB
admet-182	129	45	that	that	SCONJ
admet-182	129	46	the	the	DET
admet-182	129	47	simple	simple	ADJ
admet-182	129	48	henderson	henderson	PROPN
admet-182	129	49	-	-	PUNCT
admet-182	129	50	hasselbalch	hasselbalch	PROPN
admet-182	129	51	equation	equation	NOUN
admet-182	129	52	may	may	AUX
admet-182	129	53	not	not	PART
admet-182	129	54	always	always	ADV
admet-182	129	55	be	be	AUX
admet-182	129	56	an	an	DET
admet-182	129	57	accurate	accurate	ADJ
admet-182	129	58	predictor	predictor	NOUN
admet-182	129	59	of	of	ADP
admet-182	129	60	the	the	DET
admet-182	129	61	ph	ph	ADJ
admet-182	129	62	dependence	dependence	NOUN
admet-182	129	63	of	of	ADP
admet-182	129	64	solubility	solubility	NOUN
admet-182	129	65	.	.	PUNCT
admet-182	130	1	this	this	PRON
admet-182	130	2	is	be	AUX
admet-182	130	3	particularly	particularly	ADV
admet-182	130	4	evident	evident	ADJ
admet-182	130	5	in	in	ADP
admet-182	130	6	examples	example	NOUN
admet-182	130	7	such	such	ADJ
admet-182	130	8	as	as	ADP
admet-182	130	9	prostaglandin	prostaglandin	NOUN
admet-182	130	10	f2α	f2α	PROPN
admet-182	130	11	[	[	X
admet-182	130	12	6	6	NUM
admet-182	130	13	]	]	PUNCT
admet-182	130	14	.	.	PUNCT
admet-182	131	1	we	we	PRON
admet-182	131	2	consequently	consequently	ADV
admet-182	131	3	pursued	pursue	VERB
admet-182	131	4	possible	possible	ADJ
admet-182	131	5	explanations	explanation	NOUN
admet-182	131	6	for	for	ADP
admet-182	131	7	the	the	DET
admet-182	131	8	difference	difference	NOUN
admet-182	131	9	between	between	ADP
admet-182	131	10	sph	sph	PROPN
admet-182	131	11	-	-	PUNCT
admet-182	131	12	pka	pka	NOUN
admet-182	131	13	=	=	PUNCT
admet-182	131	14	4.70	4.70	NUM
admet-182	131	15	±	±	NUM
admet-182	131	16	0.12	0.12	NUM
admet-182	131	17	and	and	CCONJ
admet-182	131	18	the	the	DET
admet-182	131	19	uv	uv	NOUN
admet-182	131	20	-	-	PUNCT
admet-182	131	21	measured	measure	VERB
admet-182	131	22	pka	pka	NOUN
admet-182	131	23	=	=	SYM
admet-182	131	24	3.76	3.76	NUM
admet-182	131	25	±	±	NUM
admet-182	131	26	0.03	0.03	NUM
admet-182	131	27	.	.	PUNCT
admet-182	132	1	butcher	butcher	NOUN
admet-182	132	2	,	,	PUNCT
admet-182	132	3	comer	comer	PROPN
admet-182	132	4	,	,	PUNCT
admet-182	132	5	avdeef	avdeef	NOUN
admet-182	132	6	admet	admet	PROPN
admet-182	132	7	&	&	CCONJ
admet-182	132	8	dmpk	dmpk	PROPN
admet-182	132	9	3(2	3(2	NUM
admet-182	132	10	)	)	PUNCT
admet-182	132	11	(	(	PUNCT
admet-182	132	12	2015	2015	NUM
admet-182	132	13	)	)	PUNCT
admet-182	132	14	131	131	NUM
admet-182	132	15	-	-	SYM
admet-182	132	16	140	140	NUM
admet-182	132	17	136	136	NUM
admet-182	132	18	figure	figure	NOUN
admet-182	132	19	3	3	NUM
admet-182	132	20	.	.	PUNCT
admet-182	133	1	(	(	PUNCT
admet-182	133	2	a	a	X
admet-182	133	3	)	)	PUNCT
admet-182	133	4	solubility	solubility	NOUN
admet-182	133	5	profiles	profile	NOUN
admet-182	133	6	of	of	ADP
admet-182	133	7	(	(	PUNCT
admet-182	133	8	a	a	PRON
admet-182	133	9	)	)	PUNCT
admet-182	133	10	pg-300995	pg-300995	NOUN
admet-182	133	11	and	and	CCONJ
admet-182	133	12	(	(	PUNCT
admet-182	133	13	b	b	NOUN
admet-182	133	14	)	)	PUNCT
admet-182	133	15	nsc-639829	nsc-639829	NOUN
admet-182	133	16	.	.	PUNCT
admet-182	134	1	the	the	DET
admet-182	134	2	diagonal	diagonal	ADJ
admet-182	134	3	region	region	NOUN
admet-182	134	4	has	have	VERB
admet-182	134	5	slope	slope	NOUN
admet-182	134	6	of	of	ADP
admet-182	134	7	-1	-1	PUNCT
admet-182	134	8	.	.	PUNCT
admet-182	135	1	the	the	DET
admet-182	135	2	ph	ph	NOUN
admet-182	135	3	in	in	ADP
admet-182	135	4	the	the	DET
admet-182	135	5	bend	bend	NOUN
admet-182	135	6	,	,	PUNCT
admet-182	135	7	between	between	ADP
admet-182	135	8	the	the	DET
admet-182	135	9	slope	slope	NOUN
admet-182	135	10	-1	-1	NOUN
admet-182	135	11	and	and	CCONJ
admet-182	135	12	slope	slope	NOUN
admet-182	135	13	0	0	NUM
admet-182	135	14	is	be	AUX
admet-182	135	15	the	the	DET
admet-182	135	16	apparent	apparent	ADJ
admet-182	135	17	pka	pka	NOUN
admet-182	135	18	,	,	PUNCT
admet-182	135	19	which	which	PRON
admet-182	135	20	may	may	AUX
admet-182	135	21	or	or	CCONJ
admet-182	135	22	may	may	AUX
admet-182	135	23	not	not	PART
admet-182	135	24	be	be	AUX
admet-182	135	25	the	the	DET
admet-182	135	26	true	true	ADJ
admet-182	135	27	pka	pka	PROPN
admet-182	135	28	.	.	PUNCT
admet-182	136	1	a	a	DET
admet-182	136	2	step	step	NOUN
admet-182	136	3	-	-	PUNCT
admet-182	136	4	by	by	ADP
admet-182	136	5	-	-	PUNCT
admet-182	136	6	step	step	NOUN
admet-182	136	7	solubility	solubility	NOUN
admet-182	136	8	model	model	NOUN
admet-182	136	9	construction	construction	NOUN
admet-182	136	10	was	be	AUX
admet-182	136	11	described	describe	VERB
admet-182	136	12	recently	recently	ADV
admet-182	136	13	by	by	ADP
admet-182	136	14	avdeef	avdeef	PROPN
admet-182	136	15	[	[	X
admet-182	136	16	10	10	NUM
admet-182	136	17	]	]	PUNCT
admet-182	136	18	.	.	PUNCT
admet-182	137	1	knowing	know	VERB
admet-182	137	2	the	the	DET
admet-182	137	3	accurate	accurate	ADJ
admet-182	137	4	pka	pka	PROPN
admet-182	137	5	starts	start	VERB
admet-182	137	6	the	the	DET
admet-182	137	7	process	process	NOUN
admet-182	137	8	.	.	PUNCT
admet-182	138	1	the	the	DET
admet-182	138	2	shape	shape	NOUN
admet-182	138	3	of	of	ADP
admet-182	138	4	the	the	DET
admet-182	138	5	log	log	NOUN
admet-182	138	6	s	s	PART
admet-182	138	7	–	–	PUNCT
admet-182	138	8	ph	ph	ADJ
admet-182	138	9	curve	curve	NOUN
admet-182	138	10	is	be	AUX
admet-182	138	11	compared	compare	VERB
admet-182	138	12	against	against	ADP
admet-182	138	13	a	a	DET
admet-182	138	14	series	series	NOUN
admet-182	138	15	of	of	ADP
admet-182	138	16	templates	template	NOUN
admet-182	138	17	[	[	X
admet-182	138	18	4,9,10	4,9,10	NUM
admet-182	138	19	]	]	PUNCT
admet-182	138	20	.	.	PUNCT
admet-182	139	1	for	for	ADP
admet-182	139	2	the	the	DET
admet-182	139	3	profile	profile	NOUN
admet-182	139	4	in	in	ADP
admet-182	139	5	figure	figure	NOUN
admet-182	139	6	3b	3b	NUM
admet-182	139	7	,	,	PUNCT
admet-182	139	8	the	the	DET
admet-182	139	9	key	key	ADJ
admet-182	139	10	characteristics	characteristic	NOUN
admet-182	139	11	are	be	AUX
admet-182	139	12	:	:	PUNCT
admet-182	139	13	pka	pka	PROPN
admet-182	139	14	app	app	X
admet-182	139	15	>	>	X
admet-182	139	16	pka	pka	PROPN
admet-182	139	17	and	and	CCONJ
admet-182	139	18	slope	slope	NOUN
admet-182	139	19	=	=	SYM
admet-182	140	1	-1	-1	ADP
admet-182	140	2	in	in	ADP
admet-182	140	3	the	the	DET
admet-182	140	4	diagonal	diagonal	ADJ
admet-182	140	5	region	region	NOUN
admet-182	140	6	,	,	PUNCT
admet-182	140	7	suggesting	suggest	VERB
admet-182	140	8	that	that	SCONJ
admet-182	140	9	a	a	DET
admet-182	140	10	mixed	mix	VERB
admet-182	140	11	-	-	PUNCT
admet-182	140	12	charge	charge	NOUN
admet-182	140	13	dimer	dimer	NOUN
admet-182	140	14	(	(	PUNCT
admet-182	140	15	or	or	CCONJ
admet-182	140	16	higher	high	ADJ
admet-182	140	17	order	order	NOUN
admet-182	140	18	oligomer	oligomer	ADJ
admet-182	140	19	)	)	PUNCT
admet-182	140	20	needs	need	VERB
admet-182	140	21	to	to	PART
admet-182	140	22	be	be	AUX
admet-182	140	23	considered	consider	VERB
admet-182	140	24	(	(	PUNCT
admet-182	140	25	case	case	NOUN
admet-182	140	26	3b	3b	NUM
admet-182	140	27	[	[	X
admet-182	140	28	4,9,10,12	4,9,10,12	PROPN
admet-182	140	29	]	]	PUNCT
admet-182	140	30	)	)	PUNCT
admet-182	140	31	.	.	PUNCT
admet-182	141	1	the	the	DET
admet-182	141	2	log	log	NOUN
admet-182	141	3	s0	s0	PROPN
admet-182	141	4	can	can	AUX
admet-182	141	5	be	be	AUX
admet-182	141	6	estimated	estimate	VERB
admet-182	141	7	as	as	ADP
admet-182	141	8	the	the	DET
admet-182	141	9	solubility	solubility	NOUN
admet-182	141	10	in	in	ADP
admet-182	141	11	the	the	DET
admet-182	141	12	ph	ph	PROPN
admet-182	141	13	>	>	PUNCT
admet-182	141	14	>	>	X
admet-182	141	15	pka	pka	PROPN
admet-182	141	16	region	region	NOUN
admet-182	141	17	of	of	ADP
admet-182	141	18	the	the	DET
admet-182	141	19	curve	curve	NOUN
admet-182	141	20	.	.	PUNCT
admet-182	142	1	three	three	NUM
admet-182	142	2	equilibria	equilibrium	NOUN
admet-182	142	3	are	be	AUX
admet-182	142	4	needed	need	VERB
admet-182	142	5	to	to	PART
admet-182	142	6	describe	describe	VERB
admet-182	142	7	such	such	DET
admet-182	142	8	a	a	DET
admet-182	142	9	model	model	NOUN
admet-182	142	10	:	:	PUNCT
admet-182	142	11	h++b	h++b	PROPN
admet-182	142	12	↔	↔	PROPN
admet-182	142	13	bh+(pka	bh+(pka	NOUN
admet-182	142	14	)	)	PUNCT
admet-182	142	15	,	,	PUNCT
admet-182	142	16	b	b	X
admet-182	142	17	↔	↔	PROPN
admet-182	142	18	b(s	b(	NOUN
admet-182	142	19	)	)	PUNCT
admet-182	142	20	(	(	PUNCT
admet-182	142	21	1	1	NUM
admet-182	142	22	/	/	SYM
admet-182	142	23	s0	s0	PROPN
admet-182	142	24	)	)	PUNCT
admet-182	142	25	,	,	PUNCT
admet-182	142	26	and	and	CCONJ
admet-182	142	27	bh++	bh++	PROPN
admet-182	142	28	b	b	X
admet-182	142	29	↔	↔	PROPN
admet-182	142	30	bhb+	bhb+	PROPN
admet-182	142	31	(	(	PUNCT
admet-182	142	32	k2	k2	NOUN
admet-182	142	33	)	)	PUNCT
admet-182	142	34	.	.	PUNCT
admet-182	143	1	having	have	VERB
admet-182	143	2	initial	initial	ADJ
admet-182	143	3	estimates	estimate	NOUN
admet-182	143	4	of	of	ADP
admet-182	143	5	constants	constant	NOUN
admet-182	143	6	corresponding	correspond	VERB
admet-182	143	7	to	to	ADP
admet-182	143	8	proposed	propose	VERB
admet-182	143	9	equilibrium	equilibrium	NOUN
admet-182	143	10	reactions	reaction	NOUN
admet-182	143	11	,	,	PUNCT
admet-182	143	12	it	it	PRON
admet-182	143	13	is	be	AUX
admet-182	143	14	possible	possible	ADJ
admet-182	143	15	to	to	PART
admet-182	143	16	refine	refine	VERB
admet-182	143	17	the	the	DET
admet-182	143	18	model	model	NOUN
admet-182	143	19	by	by	ADP
admet-182	143	20	weighted	weight	VERB
admet-182	143	21	nonlinear	nonlinear	ADJ
admet-182	143	22	regression	regression	NOUN
admet-182	143	23	,	,	PUNCT
admet-182	143	24	a	a	DET
admet-182	143	25	procedure	procedure	NOUN
admet-182	143	26	described	describe	VERB
admet-182	143	27	elsewhere	elsewhere	ADV
admet-182	143	28	[	[	X
admet-182	143	29	18	18	NUM
admet-182	143	30	]	]	PUNCT
admet-182	143	31	.	.	PUNCT
admet-182	144	1	the	the	DET
admet-182	144	2	iterative	iterative	NOUN
admet-182	144	3	refinement	refinement	NOUN
admet-182	144	4	process	process	NOUN
admet-182	144	5	continued	continue	VERB
admet-182	144	6	to	to	PART
admet-182	144	7	convergence	convergence	VERB
admet-182	144	8	.	.	PUNCT
admet-182	145	1	figure	figure	NOUN
admet-182	145	2	4	4	NUM
admet-182	145	3	shows	show	VERB
admet-182	145	4	the	the	DET
admet-182	145	5	refined	refined	ADJ
admet-182	145	6	results	result	NOUN
admet-182	145	7	for	for	ADP
admet-182	145	8	nsc-639829	nsc-639829	NOUN
admet-182	145	9	.	.	PUNCT
admet-182	146	1	the	the	DET
admet-182	146	2	solid	solid	ADJ
admet-182	146	3	(	(	PUNCT
admet-182	146	4	red	red	ADJ
admet-182	146	5	)	)	PUNCT
admet-182	146	6	line	line	NOUN
admet-182	146	7	is	be	AUX
admet-182	146	8	the	the	DET
admet-182	146	9	best	good	ADJ
admet-182	146	10	fit	fit	NOUN
admet-182	146	11	to	to	ADP
admet-182	146	12	the	the	DET
admet-182	146	13	log	log	NOUN
admet-182	146	14	s	s	NOUN
admet-182	146	15	data	datum	NOUN
admet-182	146	16	at	at	ADP
admet-182	146	17	various	various	ADJ
admet-182	146	18	ph	ph	ADJ
admet-182	146	19	values	value	NOUN
admet-182	146	20	.	.	PUNCT
admet-182	147	1	the	the	DET
admet-182	147	2	dashed	dash	VERB
admet-182	147	3	line	line	NOUN
admet-182	147	4	is	be	AUX
admet-182	147	5	calculated	calculate	VERB
admet-182	147	6	by	by	ADP
admet-182	147	7	the	the	DET
admet-182	147	8	henderson	henderson	PROPN
admet-182	147	9	-	-	PUNCT
admet-182	147	10	hasselbalch	hasselbalch	PROPN
admet-182	147	11	equation	equation	NOUN
admet-182	147	12	,	,	PUNCT
admet-182	147	13	incorporating	incorporate	VERB
admet-182	147	14	the	the	DET
admet-182	147	15	spectrophotometrically	spectrophotometrically	ADV
admet-182	147	16	-	-	PUNCT
admet-182	147	17	measured	measure	VERB
admet-182	147	18	pka	pka	PROPN
admet-182	147	19	.	.	PUNCT
admet-182	148	1	figure	figure	NOUN
admet-182	148	2	4	4	NUM
admet-182	148	3	.	.	PUNCT
admet-182	148	4	solubility	solubility	NOUN
admet-182	148	5	profile	profile	NOUN
admet-182	148	6	of	of	ADP
admet-182	148	7	nsc-639829	nsc-639829	NOUN
admet-182	148	8	incorporating	incorporate	VERB
admet-182	148	9	the	the	DET
admet-182	148	10	uv	uv	NOUN
admet-182	148	11	-	-	PUNCT
admet-182	148	12	determined	determine	VERB
admet-182	148	13	pka	pka	PROPN
admet-182	148	14	in	in	ADP
admet-182	148	15	the	the	DET
admet-182	148	16	equilibrium	equilibrium	NOUN
admet-182	148	17	model	model	NOUN
admet-182	148	18	.	.	PUNCT
admet-182	149	1	the	the	DET
admet-182	149	2	dashed	dash	VERB
admet-182	149	3	line	line	NOUN
admet-182	149	4	is	be	AUX
admet-182	149	5	calculated	calculate	VERB
admet-182	149	6	using	use	VERB
admet-182	149	7	the	the	DET
admet-182	149	8	henderson	henderson	PROPN
admet-182	149	9	-	-	PUNCT
admet-182	149	10	hasselbalch	hasselbalch	PROPN
admet-182	149	11	equation	equation	NOUN
admet-182	149	12	.	.	PUNCT
admet-182	150	1	admet	admet	PROPN
admet-182	150	2	&	&	CCONJ
admet-182	150	3	dmpk	dmpk	PROPN
admet-182	150	4	3(2	3(2	NUM
admet-182	150	5	)	)	PUNCT
admet-182	150	6	(	(	PUNCT
admet-182	150	7	2015	2015	NUM
admet-182	150	8	)	)	PUNCT
admet-182	150	9	131	131	NUM
admet-182	150	10	-	-	SYM
admet-182	150	11	140	140	NUM
admet-182	150	12	pka	pka	NOUN
admet-182	150	13	-	-	PUNCT
admet-182	150	14	critical	critical	ADJ
admet-182	150	15	interpretations	interpretation	NOUN
admet-182	150	16	of	of	ADP
admet-182	150	17	solubility	solubility	NOUN
admet-182	150	18	-	-	PUNCT
admet-182	150	19	ph	ph	ADJ
admet-182	150	20	profiles	profile	NOUN
admet-182	150	21	doi	doi	NOUN
admet-182	150	22	:	:	PUNCT
admet-182	150	23	10.5599	10.5599	NUM
admet-182	150	24	/	/	SYM
admet-182	150	25	admet.3.2.182	admet.3.2.182	NOUN
admet-182	150	26	137	137	NUM
admet-182	150	27	figure	figure	NOUN
admet-182	150	28	5	5	NUM
admet-182	150	29	shows	show	VERB
admet-182	150	30	the	the	DET
admet-182	150	31	distribution	distribution	NOUN
admet-182	150	32	of	of	ADP
admet-182	150	33	various	various	ADJ
admet-182	150	34	species	specie	NOUN
admet-182	150	35	as	as	ADP
admet-182	150	36	a	a	DET
admet-182	150	37	function	function	NOUN
admet-182	150	38	of	of	ADP
admet-182	150	39	ph	ph	PROPN
admet-182	150	40	.	.	PROPN
admet-182	150	41	at	at	ADP
admet-182	150	42	ph	ph	NOUN
admet-182	150	43	=	=	SYM
admet-182	150	44	sph	sph	PROPN
admet-182	150	45	-	-	PUNCT
admet-182	150	46	pka	pka	PROPN
admet-182	150	47	(	(	PUNCT
admet-182	150	48	4.70	4.70	NUM
admet-182	150	49	)	)	PUNCT
admet-182	150	50	in	in	ADP
admet-182	150	51	a	a	DET
admet-182	150	52	suspension	suspension	NOUN
admet-182	150	53	containing	contain	VERB
admet-182	150	54	1	1	NUM
admet-182	150	55	mg	mg	NUM
admet-182	150	56	/	/	SYM
admet-182	150	57	ml	ml	ADV
admet-182	150	58	added	add	VERB
admet-182	150	59	drug	drug	NOUN
admet-182	150	60	,	,	PUNCT
admet-182	150	61	the	the	DET
admet-182	150	62	concentration	concentration	NOUN
admet-182	150	63	of	of	ADP
admet-182	150	64	the	the	DET
admet-182	150	65	free	free	ADJ
admet-182	150	66	base	base	NOUN
admet-182	150	67	,	,	PUNCT
admet-182	151	1	[	[	X
admet-182	151	2	b	b	X
admet-182	151	3	]	]	X
admet-182	151	4	=	=	PUNCT
admet-182	151	5	5.79	5.79	NUM
admet-182	151	6	x	x	SYM
admet-182	151	7	10	10	NUM
admet-182	151	8	-8	-8	NOUN
admet-182	151	9	m	m	PROPN
admet-182	151	10	(=	(=	X
admet-182	151	11	s0	s0	PROPN
admet-182	151	12	,	,	PUNCT
admet-182	151	13	the	the	DET
admet-182	151	14	intrinsic	intrinsic	ADJ
admet-182	151	15	solubility	solubility	NOUN
admet-182	151	16	)	)	PUNCT
admet-182	151	17	,	,	PUNCT
admet-182	151	18	accounts	account	VERB
admet-182	151	19	for	for	ADP
admet-182	151	20	66	66	NUM
admet-182	151	21	%	%	NOUN
admet-182	151	22	of	of	ADP
admet-182	151	23	the	the	DET
admet-182	151	24	total	total	ADJ
admet-182	151	25	aqueous	aqueous	ADJ
admet-182	151	26	concentration	concentration	NOUN
admet-182	151	27	of	of	ADP
admet-182	151	28	nsc-639829	nsc-639829	NOUN
admet-182	151	29	.	.	PUNCT
admet-182	152	1	at	at	ADP
admet-182	152	2	this	this	DET
admet-182	152	3	ph	ph	NOUN
admet-182	152	4	,	,	PUNCT
admet-182	152	5	[	[	X
admet-182	152	6	bh	bh	NOUN
admet-182	152	7	+	+	X
admet-182	152	8	]	]	PUNCT
admet-182	152	9	accounts	account	VERB
admet-182	152	10	for	for	ADP
admet-182	152	11	8	8	NUM
admet-182	152	12	%	%	NOUN
admet-182	152	13	of	of	ADP
admet-182	152	14	the	the	DET
admet-182	152	15	total	total	ADJ
admet-182	152	16	aqueous	aqueous	ADJ
admet-182	152	17	concentration	concentration	NOUN
admet-182	152	18	of	of	ADP
admet-182	152	19	the	the	DET
admet-182	152	20	drug	drug	NOUN
admet-182	152	21	,	,	PUNCT
admet-182	152	22	while	while	SCONJ
admet-182	152	23	[	[	X
admet-182	152	24	bhb	bhb	VERB
admet-182	152	25	+	+	X
admet-182	152	26	]	]	PUNCT
admet-182	152	27	accounts	account	VERB
admet-182	152	28	for	for	ADP
admet-182	152	29	the	the	DET
admet-182	152	30	remaining	remain	VERB
admet-182	152	31	26	26	NUM
admet-182	152	32	%	%	NOUN
admet-182	152	33	.	.	PUNCT
admet-182	153	1	the	the	DET
admet-182	153	2	molecule	molecule	NOUN
admet-182	153	3	is	be	AUX
admet-182	153	4	34	34	NUM
admet-182	153	5	%	%	NOUN
admet-182	153	6	ionized	ionize	VERB
admet-182	153	7	at	at	ADP
admet-182	153	8	this	this	DET
admet-182	153	9	ph	ph	NOUN
admet-182	153	10	.	.	PROPN
admet-182	154	1	at	at	ADP
admet-182	154	2	ph	ph	PROPN
admet-182	154	3	=	=	SYM
admet-182	154	4	pka	pka	X
admet-182	154	5	(	(	PUNCT
admet-182	154	6	3.76	3.76	NUM
admet-182	154	7	)	)	PUNCT
admet-182	154	8	in	in	ADP
admet-182	154	9	a	a	DET
admet-182	154	10	1	1	NUM
admet-182	154	11	mg	mg	NUM
admet-182	154	12	/	/	SYM
admet-182	154	13	ml	ml	NOUN
admet-182	154	14	suspension	suspension	NOUN
admet-182	154	15	,	,	PUNCT
admet-182	154	16	the	the	DET
admet-182	154	17	concentration	concentration	NOUN
admet-182	154	18	of	of	ADP
admet-182	154	19	the	the	DET
admet-182	154	20	free	free	ADJ
admet-182	154	21	base	base	NOUN
admet-182	154	22	remains	remain	VERB
admet-182	154	23	the	the	DET
admet-182	154	24	same	same	ADJ
admet-182	154	25	,	,	PUNCT
admet-182	154	26	but	but	CCONJ
admet-182	154	27	it	it	PRON
admet-182	154	28	accounts	account	VERB
admet-182	154	29	for	for	ADP
admet-182	154	30	only	only	ADV
admet-182	154	31	18	18	NUM
admet-182	154	32	%	%	NOUN
admet-182	154	33	of	of	ADP
admet-182	154	34	the	the	DET
admet-182	154	35	total	total	ADJ
admet-182	154	36	aqueous	aqueous	ADJ
admet-182	154	37	concentration	concentration	NOUN
admet-182	154	38	of	of	ADP
admet-182	154	39	nsc-639829	nsc-639829	NOUN
admet-182	154	40	.	.	PUNCT
admet-182	155	1	at	at	ADP
admet-182	155	2	this	this	DET
admet-182	155	3	ph	ph	VERB
admet-182	155	4	,	,	PUNCT
admet-182	155	5	[	[	X
admet-182	155	6	bh+	bh+	NOUN
admet-182	155	7	]	]	PUNCT
admet-182	155	8	also	also	ADV
admet-182	155	9	accounts	account	VERB
admet-182	155	10	for	for	ADP
admet-182	155	11	18	18	NUM
admet-182	155	12	%	%	NOUN
admet-182	155	13	of	of	ADP
admet-182	155	14	the	the	DET
admet-182	155	15	total	total	NOUN
admet-182	155	16	(	(	PUNCT
admet-182	155	17	[	[	X
admet-182	155	18	b	b	X
admet-182	155	19	]	]	X
admet-182	155	20	=	=	PUNCT
admet-182	156	1	[	[	X
admet-182	156	2	bh+	bh+	NOUN
admet-182	156	3	]	]	PUNCT
admet-182	156	4	when	when	SCONJ
admet-182	156	5	ph	ph	PROPN
admet-182	156	6	=	=	SYM
admet-182	156	7	pka	pka	PROPN
admet-182	156	8	)	)	PUNCT
admet-182	156	9	,	,	PUNCT
admet-182	156	10	while	while	SCONJ
admet-182	156	11	[	[	X
admet-182	156	12	bhb+	bhb+	NOUN
admet-182	156	13	]	]	PUNCT
admet-182	156	14	accounts	account	VERB
admet-182	156	15	for	for	ADP
admet-182	156	16	the	the	DET
admet-182	156	17	remaining	remain	VERB
admet-182	156	18	64	64	NUM
admet-182	156	19	%	%	NOUN
admet-182	156	20	.	.	PUNCT
admet-182	157	1	the	the	DET
admet-182	157	2	molecule	molecule	NOUN
admet-182	157	3	is	be	AUX
admet-182	157	4	82	82	NUM
admet-182	157	5	%	%	NOUN
admet-182	157	6	ionized	ionize	VERB
admet-182	157	7	at	at	ADP
admet-182	157	8	this	this	DET
admet-182	157	9	ph	ph	NOUN
admet-182	157	10	.	.	PUNCT
admet-182	158	1	according	accord	VERB
admet-182	158	2	to	to	ADP
admet-182	158	3	the	the	DET
admet-182	158	4	equilibrium	equilibrium	NOUN
admet-182	158	5	model	model	NOUN
admet-182	158	6	,	,	PUNCT
admet-182	158	7	the	the	DET
admet-182	158	8	ratio	ratio	NOUN
admet-182	158	9	[	[	X
admet-182	158	10	bhb	bhb	NOUN
admet-182	158	11	+	+	X
admet-182	158	12	]	]	PUNCT
admet-182	158	13	/[bh	/[bh	X
admet-182	159	1	+	+	NUM
admet-182	159	2	]	]	X
admet-182	159	3	=	=	SYM
admet-182	159	4	3.4	3.4	NUM
admet-182	159	5	is	be	AUX
admet-182	159	6	expected	expect	VERB
admet-182	159	7	to	to	PART
admet-182	159	8	remain	remain	VERB
admet-182	159	9	unchanged	unchanged	ADJ
admet-182	159	10	as	as	ADV
admet-182	159	11	long	long	ADV
admet-182	159	12	as	as	SCONJ
admet-182	159	13	the	the	DET
admet-182	159	14	solutions	solution	NOUN
admet-182	159	15	remain	remain	VERB
admet-182	159	16	saturated	saturated	ADJ
admet-182	159	17	(	(	PUNCT
admet-182	159	18	as	as	SCONJ
admet-182	159	19	suggested	suggest	VERB
admet-182	159	20	by	by	ADP
admet-182	159	21	the	the	DET
admet-182	159	22	two	two	NUM
admet-182	159	23	thick	thick	ADJ
admet-182	159	24	diagonal	diagonal	ADJ
admet-182	159	25	lines	line	NOUN
admet-182	159	26	of	of	ADP
admet-182	159	27	identical	identical	ADJ
admet-182	159	28	slope	slope	NOUN
admet-182	159	29	-1	-1	INTJ
admet-182	159	30	in	in	ADP
admet-182	159	31	figure	figure	NOUN
admet-182	159	32	5	5	NUM
admet-182	159	33	)	)	PUNCT
admet-182	159	34	,	,	PUNCT
admet-182	159	35	provided	provide	VERB
admet-182	159	36	there	there	PRON
admet-182	159	37	are	be	VERB
admet-182	159	38	no	no	DET
admet-182	159	39	other	other	ADJ
admet-182	159	40	unaccounted	unaccounted	ADJ
admet-182	159	41	equilibria	equilibrium	NOUN
admet-182	159	42	when	when	SCONJ
admet-182	159	43	the	the	DET
admet-182	159	44	positively	positively	ADV
admet-182	159	45	charged	charge	VERB
admet-182	159	46	species	specie	NOUN
admet-182	159	47	become	become	VERB
admet-182	159	48	less	less	ADV
admet-182	159	49	concentrated	concentrated	ADJ
admet-182	159	50	than	than	ADP
admet-182	159	51	the	the	DET
admet-182	159	52	uncharged	uncharged	ADJ
admet-182	159	53	free	free	ADJ
admet-182	159	54	base	base	NOUN
admet-182	159	55	(	(	PUNCT
admet-182	159	56	ph	ph	X
admet-182	159	57	>	>	X
admet-182	159	58	4.7	4.7	NUM
admet-182	159	59	)	)	PUNCT
admet-182	159	60	.	.	PUNCT
admet-182	160	1	figure	figure	NOUN
admet-182	160	2	5	5	NUM
admet-182	160	3	.	.	PUNCT
admet-182	160	4	speciation	speciation	NOUN
admet-182	160	5	profile	profile	NOUN
admet-182	160	6	of	of	ADP
admet-182	160	7	nsc-639829	nsc-639829	NOUN
admet-182	160	8	.	.	PUNCT
admet-182	161	1	the	the	DET
admet-182	161	2	thick	thick	ADJ
admet-182	161	3	solid	solid	ADJ
admet-182	161	4	lines	line	NOUN
admet-182	161	5	correspond	correspond	VERB
admet-182	161	6	to	to	ADP
admet-182	161	7	the	the	DET
admet-182	161	8	concentrations	concentration	NOUN
admet-182	161	9	of	of	ADP
admet-182	161	10	the	the	DET
admet-182	161	11	drug	drug	NOUN
admet-182	161	12	species	specie	NOUN
admet-182	161	13	.	.	PUNCT
admet-182	162	1	the	the	DET
admet-182	162	2	thin	thin	ADJ
admet-182	162	3	lines	line	NOUN
admet-182	162	4	correspond	correspond	VERB
admet-182	162	5	to	to	ADP
admet-182	162	6	the	the	DET
admet-182	162	7	concentrations	concentration	NOUN
admet-182	162	8	of	of	ADP
admet-182	162	9	the	the	DET
admet-182	162	10	three	three	NUM
admet-182	162	11	buffer	buffer	NOUN
admet-182	162	12	components	component	NOUN
admet-182	162	13	used	use	VERB
admet-182	162	14	to	to	PART
admet-182	162	15	simulate	simulate	VERB
admet-182	162	16	the	the	DET
admet-182	162	17	data	datum	NOUN
admet-182	162	18	:	:	PUNCT
admet-182	162	19	glycine	glycine	NOUN
admet-182	162	20	,	,	PUNCT
admet-182	162	21	phosphate	phosphate	NOUN
admet-182	162	22	,	,	PUNCT
admet-182	162	23	and	and	CCONJ
admet-182	162	24	citrate	citrate	NOUN
admet-182	162	25	.	.	PUNCT
admet-182	163	1	the	the	DET
admet-182	163	2	1	1	NUM
admet-182	163	3	mg	mg	NUM
admet-182	163	4	/	/	SYM
admet-182	163	5	ml	ml	NOUN
admet-182	163	6	used	use	VERB
admet-182	163	7	in	in	ADP
admet-182	163	8	the	the	DET
admet-182	163	9	simulation	simulation	NOUN
admet-182	163	10	suggests	suggest	VERB
admet-182	163	11	that	that	SCONJ
admet-182	163	12	all	all	PRON
admet-182	163	13	of	of	ADP
admet-182	163	14	the	the	DET
admet-182	163	15	solid	solid	ADJ
admet-182	163	16	dissolves	dissolve	NOUN
admet-182	163	17	when	when	SCONJ
admet-182	163	18	ph	ph	X
admet-182	163	19	<	<	X
admet-182	163	20	0.5	0.5	NUM
admet-182	163	21	.	.	PUNCT
admet-182	164	1	conclusions	conclusion	NOUN
admet-182	164	2	we	we	PRON
admet-182	164	3	re	re	VERB
admet-182	164	4	-	-	VERB
admet-182	164	5	analyzed	analyze	VERB
admet-182	164	6	the	the	DET
admet-182	164	7	previously	previously	ADV
admet-182	164	8	published	publish	VERB
admet-182	164	9	solubility	solubility	NOUN
admet-182	164	10	-	-	PUNCT
admet-182	164	11	ph	ph	ADJ
admet-182	164	12	data	datum	NOUN
admet-182	164	13	of	of	ADP
admet-182	164	14	two	two	NUM
admet-182	164	15	weak	weak	ADJ
admet-182	164	16	base	base	NOUN
admet-182	164	17	drugs	drug	NOUN
admet-182	164	18	.	.	PUNCT
admet-182	165	1	it	it	PRON
admet-182	165	2	was	be	AUX
admet-182	165	3	tentatively	tentatively	ADV
admet-182	165	4	proposed	propose	VERB
admet-182	165	5	,	,	PUNCT
admet-182	165	6	based	base	VERB
admet-182	165	7	on	on	ADP
admet-182	165	8	the	the	DET
admet-182	165	9	agreement	agreement	NOUN
admet-182	165	10	between	between	ADP
admet-182	165	11	the	the	DET
admet-182	165	12	apparent	apparent	ADJ
admet-182	165	13	pka	pka	PROPN
admet-182	165	14	(	(	PUNCT
admet-182	165	15	sph	sph	NOUN
admet-182	165	16	-	-	PUNCT
admet-182	165	17	pka	pka	PROPN
admet-182	165	18	)	)	PUNCT
admet-182	165	19	and	and	CCONJ
admet-182	165	20	that	that	PRON
admet-182	165	21	predicted	predict	VERB
admet-182	165	22	by	by	ADP
admet-182	165	23	marvinsketch	marvinsketch	PROPN
admet-182	165	24	and	and	CCONJ
admet-182	165	25	admet	admet	PROPN
admet-182	165	26	predictor	predictor	NOUN
admet-182	165	27	(	(	PUNCT
admet-182	165	28	but	but	CCONJ
admet-182	165	29	not	not	PART
admet-182	165	30	acd	acd	NOUN
admet-182	165	31	/	/	SYM
admet-182	165	32	percepta	percepta	NOUN
admet-182	165	33	)	)	PUNCT
admet-182	165	34	,	,	PUNCT
admet-182	165	35	that	that	SCONJ
admet-182	165	36	the	the	DET
admet-182	165	37	solubility	solubility	NOUN
admet-182	165	38	profile	profile	NOUN
admet-182	165	39	of	of	ADP
admet-182	165	40	the	the	DET
admet-182	165	41	more	more	ADV
admet-182	165	42	soluble	soluble	ADJ
admet-182	165	43	drug	drug	NOUN
admet-182	165	44	,	,	PUNCT
admet-182	165	45	pg-300995	pg-300995	PROPN
admet-182	165	46	,	,	PUNCT
admet-182	165	47	could	could	AUX
admet-182	165	48	be	be	AUX
admet-182	165	49	adequately	adequately	ADV
admet-182	165	50	predicted	predict	VERB
admet-182	165	51	by	by	ADP
admet-182	165	52	the	the	DET
admet-182	165	53	henderson	henderson	PROPN
admet-182	165	54	-	-	PUNCT
admet-182	165	55	hasselbalch	hasselbalch	PROPN
admet-182	165	56	(	(	PUNCT
admet-182	165	57	hh	hh	NOUN
admet-182	165	58	)	)	PUNCT
admet-182	165	59	equation	equation	NOUN
admet-182	165	60	.	.	PUNCT
admet-182	166	1	however	however	ADV
admet-182	166	2	,	,	PUNCT
admet-182	166	3	the	the	DET
admet-182	166	4	practically	practically	ADV
admet-182	166	5	-	-	PUNCT
admet-182	166	6	insoluble	insoluble	ADJ
admet-182	166	7	nsc-639829	nsc-639829	NOUN
admet-182	166	8	drug	drug	NOUN
admet-182	166	9	could	could	AUX
admet-182	166	10	not	not	PART
admet-182	166	11	be	be	AUX
admet-182	166	12	predicted	predict	VERB
admet-182	166	13	by	by	ADP
admet-182	166	14	the	the	DET
admet-182	166	15	simple	simple	ADJ
admet-182	166	16	hh	hh	ADJ
admet-182	166	17	equation	equation	NOUN
admet-182	166	18	.	.	PUNCT
admet-182	167	1	its	its	PRON
admet-182	167	2	pka	pka	PROPN
admet-182	167	3	was	be	AUX
admet-182	167	4	determined	determine	VERB
admet-182	167	5	here	here	ADV
admet-182	167	6	.	.	PUNCT
admet-182	168	1	the	the	DET
admet-182	168	2	inclusion	inclusion	NOUN
admet-182	168	3	of	of	ADP
admet-182	168	4	the	the	DET
admet-182	168	5	independently	independently	ADV
admet-182	168	6	-	-	PUNCT
admet-182	168	7	measured	measure	VERB
admet-182	168	8	pka	pka	NOUN
admet-182	168	9	in	in	ADP
admet-182	168	10	the	the	DET
admet-182	168	11	equilibrium	equilibrium	NOUN
admet-182	168	12	model	model	NOUN
admet-182	168	13	butcher	butcher	NOUN
admet-182	168	14	,	,	PUNCT
admet-182	168	15	comer	comer	NOUN
admet-182	168	16	,	,	PUNCT
admet-182	168	17	avdeef	avdeef	NOUN
admet-182	168	18	admet	admet	PROPN
admet-182	168	19	&	&	CCONJ
admet-182	168	20	dmpk	dmpk	PROPN
admet-182	168	21	3(2	3(2	NUM
admet-182	168	22	)	)	PUNCT
admet-182	168	23	(	(	PUNCT
admet-182	168	24	2015	2015	NUM
admet-182	168	25	)	)	PUNCT
admet-182	168	26	131	131	NUM
admet-182	168	27	-	-	SYM
admet-182	168	28	140	140	NUM
admet-182	168	29	138	138	NUM
admet-182	168	30	suggested	suggest	VERB
admet-182	168	31	that	that	SCONJ
admet-182	168	32	the	the	DET
admet-182	168	33	“	"	PUNCT
admet-182	168	34	anomalous	anomalous	ADJ
admet-182	168	35	”	"	PUNCT
admet-182	168	36	profile	profile	NOUN
admet-182	168	37	of	of	ADP
admet-182	168	38	nsc-639829	nsc-639829	NOUN
admet-182	168	39	can	can	AUX
admet-182	168	40	be	be	AUX
admet-182	168	41	explained	explain	VERB
admet-182	168	42	by	by	ADP
admet-182	168	43	presence	presence	NOUN
admet-182	168	44	of	of	ADP
admet-182	168	45	a	a	DET
admet-182	168	46	mixed	mixed	ADJ
admet-182	168	47	-	-	PUNCT
admet-182	168	48	charge	charge	NOUN
admet-182	168	49	cationic	cationic	ADJ
admet-182	168	50	dimer	dimer	NOUN
admet-182	168	51	(	(	PUNCT
admet-182	168	52	bhb	bhb	NOUN
admet-182	168	53	+	+	PUNCT
admet-182	168	54	)	)	PUNCT
admet-182	168	55	.	.	PUNCT
admet-182	169	1	this	this	PRON
admet-182	169	2	illustrates	illustrate	VERB
admet-182	169	3	that	that	SCONJ
admet-182	169	4	an	an	DET
admet-182	169	5	independently	independently	ADV
admet-182	169	6	-	-	PUNCT
admet-182	169	7	determined	determine	VERB
admet-182	169	8	accurate	accurate	ADJ
admet-182	169	9	pka	pka	PROPN
admet-182	169	10	is	be	AUX
admet-182	169	11	critical	critical	ADJ
admet-182	169	12	to	to	ADP
admet-182	169	13	interpreting	interpret	VERB
admet-182	169	14	solubility	solubility	NOUN
admet-182	169	15	-	-	PUNCT
admet-182	169	16	ph	ph	ADJ
admet-182	169	17	data	datum	NOUN
admet-182	169	18	of	of	ADP
admet-182	169	19	ionizable	ionizable	ADJ
admet-182	169	20	compounds	compound	NOUN
admet-182	169	21	.	.	PUNCT
admet-182	170	1	however	however	ADV
admet-182	170	2	,	,	PUNCT
admet-182	170	3	predicted	predict	VERB
admet-182	170	4	pka	pka	PROPN
admet-182	170	5	values	value	NOUN
admet-182	170	6	can	can	AUX
admet-182	170	7	be	be	AUX
admet-182	170	8	very	very	ADV
admet-182	170	9	helpful	helpful	ADJ
admet-182	170	10	guides	guide	NOUN
admet-182	170	11	in	in	ADP
admet-182	170	12	the	the	DET
admet-182	170	13	initial	initial	ADJ
admet-182	170	14	stages	stage	NOUN
admet-182	170	15	of	of	ADP
admet-182	170	16	such	such	ADJ
admet-182	170	17	investigations	investigation	NOUN
admet-182	170	18	.	.	PUNCT
admet-182	171	1	apparently	apparently	ADV
admet-182	171	2	,	,	PUNCT
admet-182	171	3	the	the	DET
admet-182	171	4	simple	simple	ADJ
admet-182	171	5	henderson	henderson	PROPN
admet-182	171	6	-	-	PUNCT
admet-182	171	7	hasselbalch	hasselbalch	PROPN
admet-182	171	8	equation	equation	NOUN
admet-182	171	9	holds	hold	VERB
admet-182	171	10	for	for	ADP
admet-182	171	11	pg-300995	pg-300995	NOUN
admet-182	171	12	,	,	PUNCT
admet-182	171	13	but	but	CCONJ
admet-182	171	14	not	not	PART
admet-182	171	15	nsc-639829	nsc-639829	NOUN
admet-182	171	16	.	.	PUNCT
admet-182	172	1	acknowledgements	acknowledgement	NOUN
admet-182	172	2	the	the	DET
admet-182	172	3	authors	author	NOUN
admet-182	172	4	wish	wish	VERB
admet-182	172	5	to	to	PART
admet-182	172	6	thank	thank	VERB
admet-182	172	7	professor	professor	PROPN
admet-182	172	8	samuel	samuel	PROPN
admet-182	172	9	yalkowsky	yalkowsky	PROPN
admet-182	172	10	(	(	PUNCT
admet-182	172	11	univ	univ	PROPN
admet-182	172	12	.	.	PROPN
admet-182	172	13	of	of	ADP
admet-182	172	14	arizona	arizona	PROPN
admet-182	172	15	)	)	PUNCT
admet-182	172	16	for	for	ADP
admet-182	172	17	kindly	kindly	ADV
admet-182	172	18	providing	provide	VERB
admet-182	172	19	a	a	DET
admet-182	172	20	sample	sample	NOUN
admet-182	172	21	of	of	ADP
admet-182	172	22	nsc-639829	nsc-639829	NOUN
admet-182	172	23	.	.	PUNCT
admet-182	173	1	we	we	PRON
admet-182	173	2	are	be	AUX
admet-182	173	3	also	also	ADV
admet-182	173	4	grateful	grateful	ADJ
admet-182	173	5	for	for	ADP
admet-182	173	6	very	very	ADV
admet-182	173	7	stimulating	stimulating	ADJ
admet-182	173	8	discussions	discussion	NOUN
admet-182	173	9	with	with	ADP
admet-182	173	10	drs	dr	NOUN
admet-182	173	11	.	.	PUNCT
admet-182	174	1	robert	robert	PROPN
admet-182	174	2	fraczkiewicz	fraczkiewicz	PROPN
admet-182	174	3	(	(	PUNCT
admet-182	174	4	simulations	simulation	NOUN
admet-182	174	5	plus	plus	CCONJ
admet-182	174	6	)	)	PUNCT
admet-182	174	7	,	,	PUNCT
admet-182	174	8	andreas	andreas	PROPN
admet-182	174	9	klamt	klamt	PROPN
admet-182	174	10	(	(	PUNCT
admet-182	174	11	cosmologic	cosmologic	NOUN
admet-182	174	12	)	)	PUNCT
admet-182	174	13	,	,	PUNCT
admet-182	174	14	and	and	CCONJ
admet-182	174	15	jozsef	jozsef	PROPN
admet-182	174	16	szegezdi	szegezdi	PROPN
admet-182	174	17	(	(	PUNCT
admet-182	174	18	chemaxon	chemaxon	PROPN
admet-182	174	19	)	)	PUNCT
admet-182	174	20	,	,	PUNCT
admet-182	174	21	regarding	regard	VERB
admet-182	174	22	the	the	DET
admet-182	174	23	possible	possible	ADJ
admet-182	174	24	effect	effect	NOUN
admet-182	174	25	of	of	ADP
admet-182	174	26	internally	internally	ADV
admet-182	174	27	-	-	PUNCT
admet-182	174	28	stabilized	stabilize	VERB
admet-182	174	29	hydrogen	hydrogen	NOUN
admet-182	174	30	bonding	bonding	NOUN
admet-182	174	31	in	in	ADP
admet-182	174	32	nsc-639829	nsc-639829	NOUN
admet-182	174	33	on	on	ADP
admet-182	174	34	the	the	DET
admet-182	174	35	accurate	accurate	ADJ
admet-182	174	36	prediction	prediction	NOUN
admet-182	174	37	of	of	ADP
admet-182	174	38	the	the	DET
admet-182	174	39	pka(s	pka(s	PROPN
admet-182	174	40	)	)	PUNCT
admet-182	174	41	.	.	PUNCT
admet-182	175	1	also	also	ADV
admet-182	175	2	,	,	PUNCT
admet-182	175	3	robert	robert	PROPN
admet-182	175	4	fraczkiewicz	fraczkiewicz	PROPN
admet-182	175	5	was	be	AUX
admet-182	175	6	kind	kind	ADJ
admet-182	175	7	to	to	PART
admet-182	175	8	share	share	VERB
admet-182	175	9	the	the	DET
admet-182	175	10	prediction	prediction	NOUN
admet-182	175	11	of	of	ADP
admet-182	175	12	the	the	DET
admet-182	175	13	pka	pka	PROPN
admet-182	175	14	of	of	ADP
admet-182	175	15	pg300995	pg300995	PROPN
admet-182	175	16	,	,	PUNCT
admet-182	175	17	using	use	VERB
admet-182	175	18	admet	admet	PROPN
admet-182	175	19	predictor	predictor	NOUN
admet-182	175	20	.	.	PUNCT
admet-182	176	1	references	reference	NOUN
admet-182	176	2	[	[	X
admet-182	176	3	1	1	NUM
admet-182	176	4	]	]	X
admet-182	176	5	e.	e.	PROPN
admet-182	176	6	baka	baka	PROPN
admet-182	176	7	,	,	PUNCT
admet-182	176	8	j.e.a	j.e.a	PROPN
admet-182	176	9	.	.	PUNCT
admet-182	176	10	comer	comer	PROPN
admet-182	176	11	,	,	PUNCT
admet-182	176	12	k.	k.	PROPN
admet-182	176	13	takács	takács	PROPN
admet-182	176	14	-	-	PUNCT
admet-182	176	15	novák	novák	PROPN
admet-182	176	16	,	,	PUNCT
admet-182	176	17	j.	j.	PROPN
admet-182	176	18	pharm	pharm	PROPN
admet-182	176	19	.	.	PUNCT
admet-182	176	20	biomed	biome	VERB
admet-182	176	21	.	.	PUNCT
admet-182	177	1	anal	anal	ADJ
admet-182	177	2	.	.	PUNCT
admet-182	178	1	46	46	NUM
admet-182	178	2	(	(	PUNCT
admet-182	178	3	2008	2008	NUM
admet-182	178	4	)	)	PUNCT
admet-182	178	5	335	335	NUM
admet-182	178	6	-	-	SYM
admet-182	178	7	341	341	NUM
admet-182	178	8	.	.	PUNCT
admet-182	179	1	[	[	X
admet-182	179	2	2	2	NUM
admet-182	179	3	]	]	PUNCT
admet-182	179	4	i.	i.	PROPN
admet-182	179	5	zimmermann	zimmermann	PROPN
admet-182	179	6	,	,	PUNCT
admet-182	179	7	int	int	NOUN
admet-182	179	8	.	.	PUNCT
admet-182	180	1	j.	j.	PROPN
admet-182	180	2	pharm	pharm	PROPN
admet-182	180	3	.	.	PUNCT
admet-182	181	1	13	13	NUM
admet-182	181	2	(	(	PUNCT
admet-182	181	3	1983	1983	NUM
admet-182	181	4	)	)	PUNCT
admet-182	181	5	57	57	NUM
admet-182	181	6	-	-	SYM
admet-182	181	7	65	65	NUM
admet-182	181	8	.	.	PUNCT
admet-182	182	1	[	[	X
admet-182	182	2	3	3	X
admet-182	182	3	]	]	PUNCT
admet-182	182	4	r.	r.	PROPN
admet-182	182	5	j.	j.	PROPN
admet-182	182	6	prankerd	prankerd	PROPN
admet-182	182	7	.	.	PUNCT
admet-182	183	1	critical	critical	ADJ
admet-182	183	2	compilation	compilation	NOUN
admet-182	183	3	of	of	ADP
admet-182	183	4	pka	pka	PROPN
admet-182	183	5	values	value	NOUN
admet-182	183	6	for	for	ADP
admet-182	183	7	pharmaceutical	pharmaceutical	ADJ
admet-182	183	8	substances	substance	NOUN
admet-182	183	9	.	.	PUNCT
admet-182	184	1	in	in	ADP
admet-182	184	2	:	:	PUNCT
admet-182	184	3	h.	h.	PROPN
admet-182	184	4	brittain	brittain	PROPN
admet-182	184	5	(	(	PUNCT
admet-182	184	6	ed	ed	NOUN
admet-182	184	7	.	.	PUNCT
admet-182	184	8	)	)	PUNCT
admet-182	184	9	.	.	PUNCT
admet-182	185	1	profiles	profile	NOUN
admet-182	185	2	of	of	ADP
admet-182	185	3	drug	drug	NOUN
admet-182	185	4	substances	substance	NOUN
admet-182	185	5	,	,	PUNCT
admet-182	185	6	excipients	excipient	NOUN
admet-182	185	7	,	,	PUNCT
admet-182	185	8	and	and	CCONJ
admet-182	185	9	related	related	ADJ
admet-182	185	10	methodology	methodology	NOUN
admet-182	185	11	.	.	PUNCT
admet-182	186	1	vol	vol	NOUN
admet-182	186	2	.	.	PUNCT
admet-182	187	1	33	33	NUM
admet-182	187	2	.	.	PUNCT
admet-182	188	1	elsevier	elsevier	PROPN
admet-182	188	2	,	,	PUNCT
admet-182	188	3	new	new	PROPN
admet-182	188	4	york	york	PROPN
admet-182	188	5	,	,	PUNCT
admet-182	188	6	2007	2007	NUM
admet-182	188	7	.	.	PUNCT
admet-182	189	1	[	[	X
admet-182	189	2	4	4	NUM
admet-182	189	3	]	]	PUNCT
admet-182	189	4	a.	a.	NOUN
admet-182	189	5	avdeef	avdeef	PROPN
admet-182	189	6	,	,	PUNCT
admet-182	189	7	adv	adv	PROPN
admet-182	189	8	.	.	PUNCT
admet-182	189	9	drug	drug	PROPN
admet-182	189	10	deliv	deliv	PROPN
admet-182	189	11	.	.	PUNCT
admet-182	190	1	rev	rev	PROPN
admet-182	190	2	.	.	PROPN
admet-182	190	3	59	59	NUM
admet-182	190	4	(	(	PUNCT
admet-182	190	5	2007	2007	NUM
admet-182	190	6	)	)	PUNCT
admet-182	190	7	568	568	NUM
admet-182	190	8	-	-	SYM
admet-182	190	9	590	590	NUM
admet-182	190	10	.	.	PUNCT
admet-182	191	1	[	[	X
admet-182	191	2	5	5	NUM
admet-182	191	3	]	]	X
admet-182	191	4	s.h	s.h	ADJ
admet-182	191	5	.	.	NOUN
admet-182	191	6	yalkowsky	yalkowsky	ADJ
admet-182	191	7	,	,	PUNCT
admet-182	191	8	g.	g.	PROPN
admet-182	191	9	zografi	zografi	PROPN
admet-182	191	10	,	,	PUNCT
admet-182	191	11	j.	j.	PROPN
admet-182	191	12	colloid	colloid	PROPN
admet-182	191	13	inter	inter	PROPN
admet-182	191	14	.	.	PUNCT
admet-182	192	1	sci	sci	PROPN
admet-182	192	2	.	.	PROPN
admet-182	193	1	34	34	NUM
admet-182	193	2	(	(	PUNCT
admet-182	193	3	1970	1970	NUM
admet-182	193	4	)	)	PUNCT
admet-182	193	5	525	525	NUM
admet-182	193	6	-	-	SYM
admet-182	193	7	533	533	NUM
admet-182	193	8	.	.	PUNCT
admet-182	194	1	[	[	X
admet-182	194	2	6	6	NUM
admet-182	194	3	]	]	X
admet-182	194	4	t.j	t.j	PROPN
admet-182	194	5	.	.	PROPN
admet-182	194	6	roseman	roseman	PROPN
admet-182	194	7	,	,	PUNCT
admet-182	194	8	s.h	s.h	PROPN
admet-182	194	9	.	.	PROPN
admet-182	194	10	yalkowsky	yalkowsky	PROPN
admet-182	194	11	,	,	PUNCT
admet-182	194	12	j.	j.	PROPN
admet-182	194	13	pharm	pharm	PROPN
admet-182	194	14	.	.	PUNCT
admet-182	195	1	sci	sci	PROPN
admet-182	195	2	.	.	PROPN
admet-182	196	1	62	62	NUM
admet-182	196	2	(	(	PUNCT
admet-182	196	3	1973	1973	NUM
admet-182	196	4	)	)	PUNCT
admet-182	196	5	1680	1680	NUM
admet-182	196	6	-	-	SYM
admet-182	196	7	1685	1685	NUM
admet-182	196	8	.	.	PUNCT
admet-182	197	1	[	[	X
admet-182	197	2	7	7	X
admet-182	197	3	]	]	X
admet-182	197	4	t.	t.	PROPN
admet-182	197	5	higuchi	higuchi	PROPN
admet-182	197	6	,	,	PUNCT
admet-182	197	7	m.	m.	NOUN
admet-182	197	8	gupta	gupta	PROPN
admet-182	197	9	,	,	PUNCT
admet-182	197	10	l.w	l.w	PROPN
admet-182	197	11	.	.	PROPN
admet-182	197	12	busse	busse	PROPN
admet-182	197	13	,	,	PUNCT
admet-182	197	14	j.	j.	PROPN
admet-182	197	15	am	am	PROPN
admet-182	197	16	.	.	PUNCT
admet-182	197	17	pharm	pharm	PROPN
admet-182	197	18	.	.	PUNCT
admet-182	198	1	assoc	assoc	PROPN
admet-182	198	2	.	.	PUNCT
admet-182	199	1	42	42	NUM
admet-182	199	2	(	(	PUNCT
admet-182	199	3	1953	1953	NUM
admet-182	199	4	)	)	PUNCT
admet-182	199	5	157	157	NUM
admet-182	199	6	-	-	SYM
admet-182	199	7	161	161	NUM
admet-182	199	8	.	.	PUNCT
admet-182	200	1	[	[	X
admet-182	200	2	8	8	NUM
admet-182	200	3	]	]	X
admet-182	200	4	e.	e.	PROPN
admet-182	200	5	shoghi	shoghi	PROPN
admet-182	200	6	,	,	PUNCT
admet-182	200	7	e.	e.	PROPN
admet-182	200	8	fuguet	fuguet	PROPN
admet-182	200	9	,	,	PUNCT
admet-182	200	10	e.	e.	PROPN
admet-182	200	11	bosch	bosch	PROPN
admet-182	200	12	,	,	PUNCT
admet-182	200	13	c.	c.	PROPN
admet-182	200	14	rafols	rafols	PROPN
admet-182	200	15	,	,	PUNCT
admet-182	200	16	eur	eur	PROPN
admet-182	200	17	.	.	PUNCT
admet-182	201	1	j.	j.	PROPN
admet-182	201	2	pharm	pharm	PROPN
admet-182	201	3	.	.	PUNCT
admet-182	202	1	sci	sci	PROPN
admet-182	202	2	.	.	PROPN
admet-182	203	1	48	48	NUM
admet-182	203	2	(	(	PUNCT
admet-182	203	3	2012	2012	NUM
admet-182	203	4	)	)	PUNCT
admet-182	203	5	290	290	NUM
admet-182	203	6	-	-	SYM
admet-182	203	7	300	300	NUM
admet-182	203	8	.	.	PUNCT
admet-182	204	1	[	[	X
admet-182	204	2	9	9	NUM
admet-182	204	3	]	]	PUNCT
admet-182	204	4	a.	a.	NOUN
admet-182	204	5	avdeef	avdeef	PROPN
admet-182	204	6	.	.	PUNCT
admet-182	205	1	absorption	absorption	NOUN
admet-182	205	2	and	and	CCONJ
admet-182	205	3	drug	drug	NOUN
admet-182	205	4	development	development	PROPN
admet-182	205	5	second	second	PROPN
admet-182	205	6	edition	edition	NOUN
admet-182	205	7	,	,	PUNCT
admet-182	205	8	wiley	wiley	NOUN
admet-182	205	9	-	-	PUNCT
admet-182	205	10	interscience	interscience	PROPN
admet-182	205	11	,	,	PUNCT
admet-182	205	12	hoboken	hoboken	PROPN
admet-182	205	13	,	,	PUNCT
admet-182	205	14	nj	nj	PROPN
admet-182	205	15	,	,	PUNCT
admet-182	205	16	2012	2012	NUM
admet-182	205	17	,	,	PUNCT
admet-182	205	18	pp	pp	ADV
admet-182	205	19	.	.	PUNCT
admet-182	206	1	251	251	NUM
admet-182	206	2	-	-	SYM
admet-182	206	3	318	318	NUM
admet-182	206	4	.	.	PUNCT
admet-182	207	1	[	[	X
admet-182	207	2	10	10	NUM
admet-182	207	3	]	]	PUNCT
admet-182	207	4	a.	a.	NOUN
admet-182	207	5	avdeef	avdeef	PROPN
admet-182	207	6	,	,	PUNCT
admet-182	207	7	admet	admet	PROPN
admet-182	207	8	&	&	CCONJ
admet-182	207	9	dmpk	dmpk	PROPN
admet-182	207	10	2(1	2(1	NUM
admet-182	207	11	)	)	PUNCT
admet-182	207	12	(	(	PUNCT
admet-182	207	13	2014	2014	NUM
admet-182	207	14	)	)	PUNCT
admet-182	207	15	33	33	NUM
admet-182	207	16	-	-	SYM
admet-182	207	17	42	42	NUM
admet-182	207	18	.	.	PUNCT
admet-182	208	1	[	[	X
admet-182	208	2	11	11	NUM
admet-182	208	3	]	]	PUNCT
admet-182	208	4	c.a.s	c.a.s	PROPN
admet-182	208	5	.	.	PROPN
admet-182	208	6	bergström	bergström	PROPN
admet-182	208	7	,	,	PUNCT
admet-182	208	8	k.	k.	PROPN
admet-182	208	9	luthman	luthman	PROPN
admet-182	208	10	,	,	PUNCT
admet-182	208	11	p.	p.	PROPN
admet-182	208	12	artursson	artursson	PROPN
admet-182	208	13	,	,	PUNCT
admet-182	208	14	eur	eur	PROPN
admet-182	208	15	.	.	PUNCT
admet-182	209	1	j.	j.	PROPN
admet-182	209	2	pharm	pharm	PROPN
admet-182	209	3	.	.	PUNCT
admet-182	210	1	sci	sci	PROPN
admet-182	210	2	.	.	PROPN
admet-182	211	1	22	22	NUM
admet-182	211	2	(	(	PUNCT
admet-182	211	3	2004	2004	NUM
admet-182	211	4	)	)	PUNCT
admet-182	211	5	387	387	NUM
admet-182	211	6	-	-	SYM
admet-182	211	7	398	398	NUM
admet-182	211	8	.	.	PUNCT
admet-182	212	1	[	[	X
admet-182	212	2	12	12	NUM
admet-182	212	3	]	]	PUNCT
admet-182	212	4	a.	a.	NOUN
admet-182	212	5	avdeef	avdeef	PROPN
admet-182	212	6	,	,	PUNCT
admet-182	212	7	admet	admet	PROPN
admet-182	212	8	&	&	CCONJ
admet-182	212	9	dmpk	dmpk	PROPN
admet-182	212	10	2(1	2(1	NUM
admet-182	212	11	)	)	PUNCT
admet-182	212	12	(	(	PUNCT
admet-182	212	13	2014	2014	NUM
admet-182	212	14	)	)	PUNCT
admet-182	212	15	43	43	NUM
admet-182	212	16	-	-	SYM
admet-182	212	17	55	55	NUM
admet-182	212	18	.	.	PUNCT
admet-182	213	1	[	[	X
admet-182	213	2	13	13	NUM
admet-182	213	3	]	]	PUNCT
admet-182	213	4	j.	j.	PROPN
admet-182	213	5	comer	comer	PROPN
admet-182	213	6	,	,	PUNCT
admet-182	213	7	k.	k.	PROPN
admet-182	213	8	box	box	PROPN
admet-182	213	9	,	,	PUNCT
admet-182	213	10	j.	j.	PROPN
admet-182	213	11	assoc	assoc	PROPN
admet-182	213	12	.	.	PUNCT
admet-182	213	13	lab	lab	PROPN
admet-182	213	14	.	.	PUNCT
admet-182	213	15	automat	automat	PROPN
admet-182	213	16	.	.	PROPN
admet-182	213	17	8	8	NUM
admet-182	213	18	(	(	PUNCT
admet-182	213	19	2003	2003	NUM
admet-182	213	20	)	)	PUNCT
admet-182	213	21	55	55	NUM
admet-182	213	22	-	-	SYM
admet-182	213	23	59	59	NUM
admet-182	213	24	.	.	PUNCT
admet-182	214	1	[	[	X
admet-182	214	2	14	14	NUM
admet-182	214	3	]	]	X
admet-182	214	4	n.	n.	PROPN
admet-182	214	5	sun	sun	PROPN
admet-182	214	6	,	,	PUNCT
admet-182	214	7	a.	a.	NOUN
admet-182	214	8	avdeef	avdeef	PROPN
admet-182	214	9	,	,	PUNCT
admet-182	214	10	j.	j.	PROPN
admet-182	214	11	pharm	pharm	PROPN
admet-182	214	12	.	.	PUNCT
admet-182	214	13	biomed	biome	VERB
admet-182	214	14	.	.	PUNCT
admet-182	215	1	anal	anal	ADJ
admet-182	215	2	.	.	PUNCT
admet-182	216	1	56	56	NUM
admet-182	216	2	(	(	PUNCT
admet-182	216	3	2011	2011	NUM
admet-182	216	4	)	)	PUNCT
admet-182	216	5	173	173	NUM
admet-182	216	6	-	-	SYM
admet-182	216	7	182	182	NUM
admet-182	216	8	.	.	PUNCT
admet-182	217	1	[	[	X
admet-182	217	2	15	15	NUM
admet-182	217	3	]	]	X
admet-182	217	4	k.j	k.j	PROPN
admet-182	217	5	.	.	PROPN
admet-182	217	6	box	box	PROPN
admet-182	217	7	,	,	PUNCT
admet-182	217	8	g.	g.	PROPN
admet-182	217	9	völgyi	völgyi	PROPN
admet-182	217	10	,	,	PUNCT
admet-182	217	11	r.	r.	PROPN
admet-182	217	12	ruiz	ruiz	PROPN
admet-182	217	13	,	,	PUNCT
admet-182	217	14	j.e	j.e	PROPN
admet-182	217	15	.	.	PROPN
admet-182	217	16	comer	comer	PROPN
admet-182	217	17	,	,	PUNCT
admet-182	217	18	k.	k.	PROPN
admet-182	217	19	takács	takács	PROPN
admet-182	217	20	-	-	PUNCT
admet-182	217	21	novák	novák	PROPN
admet-182	217	22	,	,	PUNCT
admet-182	217	23	e.	e.	PROPN
admet-182	217	24	bosch	bosch	PROPN
admet-182	217	25	,	,	PUNCT
admet-182	217	26	c.	c.	PROPN
admet-182	217	27	ràfols	ràfols	PROPN
admet-182	217	28	,	,	PUNCT
admet-182	217	29	m.	m.	NOUN
admet-182	217	30	rosés	rosés	PROPN
admet-182	217	31	,	,	PUNCT
admet-182	217	32	helv	helv	PROPN
admet-182	217	33	.	.	PUNCT
admet-182	218	1	chim	chim	PROPN
admet-182	218	2	.	.	PUNCT
admet-182	219	1	acta	acta	PROPN
admet-182	219	2	90	90	NUM
admet-182	219	3	(	(	PUNCT
admet-182	219	4	2007	2007	NUM
admet-182	219	5	)	)	PUNCT
admet-182	219	6	1538	1538	NUM
admet-182	219	7	-	-	SYM
admet-182	219	8	1553	1553	NUM
admet-182	219	9	.	.	PUNCT
admet-182	220	1	[	[	X
admet-182	220	2	16	16	NUM
admet-182	220	3	]	]	X
admet-182	220	4	y.	y.	PROPN
admet-182	220	5	ran	run	VERB
admet-182	220	6	,	,	PUNCT
admet-182	220	7	a.	a.	NOUN
admet-182	220	8	jain	jain	PROPN
admet-182	220	9	,	,	PUNCT
admet-182	220	10	s.h	s.h	PROPN
admet-182	220	11	.	.	PROPN
admet-182	220	12	yalkowsky	yalkowsky	PROPN
admet-182	220	13	,	,	PUNCT
admet-182	220	14	j.	j.	PROPN
admet-182	220	15	pharm	pharm	PROPN
admet-182	220	16	.	.	PUNCT
admet-182	221	1	sci	sci	PROPN
admet-182	221	2	.	.	PROPN
admet-182	222	1	94	94	NUM
admet-182	222	2	(	(	PUNCT
admet-182	222	3	2005	2005	NUM
admet-182	222	4	)	)	PUNCT
admet-182	222	5	297	297	NUM
admet-182	222	6	-	-	SYM
admet-182	222	7	303	303	NUM
admet-182	222	8	.	.	PUNCT
admet-182	223	1	[	[	X
admet-182	223	2	17	17	NUM
admet-182	223	3	]	]	X
admet-182	223	4	n.	n.	PROPN
admet-182	223	5	jain	jain	PROPN
admet-182	223	6	,	,	PUNCT
admet-182	223	7	g.	g.	PROPN
admet-182	223	8	yang	yang	PROPN
admet-182	223	9	,	,	PUNCT
admet-182	223	10	s.e	s.e	PROPN
admet-182	223	11	.	.	PROPN
admet-182	223	12	tabibi	tabibi	NOUN
admet-182	223	13	,	,	PUNCT
admet-182	223	14	s.h	s.h	PROPN
admet-182	223	15	.	.	NOUN
admet-182	223	16	yalkowsky	yalkowsky	ADJ
admet-182	223	17	,	,	PUNCT
admet-182	223	18	int	int	NOUN
admet-182	223	19	.	.	PUNCT
admet-182	224	1	j.	j.	PROPN
admet-182	224	2	pharm	pharm	PROPN
admet-182	224	3	.	.	PUNCT
admet-182	225	1	225	225	NUM
admet-182	225	2	(	(	PUNCT
admet-182	225	3	2001	2001	NUM
admet-182	225	4	)	)	PUNCT
admet-182	225	5	41	41	NUM
admet-182	225	6	-	-	SYM
admet-182	225	7	47	47	NUM
admet-182	225	8	.	.	PUNCT
admet-182	226	1	[	[	X
admet-182	226	2	18	18	NUM
admet-182	226	3	]	]	X
admet-182	226	4	g.	g.	PROPN
admet-182	226	5	völgyi	völgyi	PROPN
admet-182	226	6	,	,	PUNCT
admet-182	226	7	a.	a.	NOUN
admet-182	226	8	marosi	marosi	PROPN
admet-182	226	9	,	,	PUNCT
admet-182	226	10	k.	k.	PROPN
admet-182	226	11	takács	takács	PROPN
admet-182	226	12	-	-	PUNCT
admet-182	226	13	novák	novák	PROPN
admet-182	226	14	,	,	PUNCT
admet-182	226	15	a.	a.	PROPN
admet-182	226	16	avdeef	avdeef	PROPN
admet-182	226	17	,	,	PUNCT
admet-182	226	18	admet	admet	PROPN
admet-182	226	19	&	&	CCONJ
admet-182	226	20	dmpk	dmpk	PROPN
admet-182	226	21	1(4	1(4	NUM
admet-182	226	22	)	)	PUNCT
admet-182	226	23	(	(	PUNCT
admet-182	226	24	2013	2013	NUM
admet-182	226	25	)	)	PUNCT
admet-182	226	26	48	48	NUM
admet-182	226	27	-	-	SYM
admet-182	226	28	62	62	NUM
admet-182	226	29	.	.	PUNCT
admet-182	227	1	admet	admet	PROPN
admet-182	227	2	&	&	CCONJ
admet-182	227	3	dmpk	dmpk	PROPN
admet-182	227	4	3(2	3(2	NUM
admet-182	227	5	)	)	PUNCT
admet-182	227	6	(	(	PUNCT
admet-182	227	7	2015	2015	NUM
admet-182	227	8	)	)	PUNCT
admet-182	227	9	131	131	NUM
admet-182	227	10	-	-	SYM
admet-182	227	11	140	140	NUM
admet-182	227	12	pka	pka	NOUN
admet-182	227	13	-	-	PUNCT
admet-182	227	14	critical	critical	ADJ
admet-182	227	15	interpretations	interpretation	NOUN
admet-182	227	16	of	of	ADP
admet-182	227	17	solubility	solubility	NOUN
admet-182	227	18	-	-	PUNCT
admet-182	227	19	ph	ph	ADJ
admet-182	227	20	profiles	profile	NOUN
admet-182	227	21	doi	doi	NOUN
admet-182	227	22	:	:	PUNCT
admet-182	227	23	10.5599	10.5599	NUM
admet-182	227	24	/	/	SYM
admet-182	227	25	admet.3.2.182	admet.3.2.182	NOUN
admet-182	227	26	139	139	NUM
admet-182	227	27	appendix	appendix	NOUN
admet-182	227	28	–	–	PUNCT
admet-182	227	29	derivation	derivation	NOUN
admet-182	227	30	of	of	ADP
admet-182	227	31	the	the	DET
admet-182	227	32	solubility	solubility	NOUN
admet-182	227	33	ph	ph	NOUN
admet-182	227	34	equations	equation	NOUN
admet-182	227	35	in	in	ADP
admet-182	227	36	the	the	DET
admet-182	227	37	case	case	NOUN
admet-182	227	38	of	of	ADP
admet-182	227	39	a	a	DET
admet-182	227	40	monoprotic	monoprotic	ADJ
admet-182	227	41	weak	weak	ADJ
admet-182	227	42	base	base	NOUN
admet-182	227	43	,	,	PUNCT
admet-182	227	44	a	a	DET
admet-182	227	45	saturated	saturate	VERB
admet-182	227	46	solution	solution	NOUN
admet-182	227	47	can	can	AUX
admet-182	227	48	be	be	AUX
admet-182	227	49	defined	define	VERB
admet-182	227	50	by	by	ADP
admet-182	227	51	the	the	DET
admet-182	227	52	equations	equation	NOUN
admet-182	227	53	and	and	CCONJ
admet-182	227	54	the	the	DET
admet-182	227	55	corresponding	corresponding	ADJ
admet-182	227	56	constants	constant	NOUN
admet-182	227	57	bh	bh	NOUN
admet-182	227	58	+	+	CCONJ
admet-182	227	59			NOUN
admet-182	227	60	h	h	NOUN
admet-182	228	1	+	+	CCONJ
admet-182	229	1	+	+	CCONJ
admet-182	229	2	b	b	X
admet-182	229	3	ka	ka	NOUN
admet-182	230	1	=	=	PUNCT
admet-182	231	1	[	[	X
admet-182	231	2	h	h	NOUN
admet-182	232	1	+	+	X
admet-182	232	2	]	]	PUNCT
admet-182	232	3	[	[	X
admet-182	232	4	b	b	X
admet-182	232	5	]	]	X
admet-182	232	6	/	/	PUNCT
admet-182	233	1	[	[	X
admet-182	233	2	bh	bh	NOUN
admet-182	233	3	+	+	X
admet-182	233	4	]	]	X
admet-182	233	5	(	(	PUNCT
admet-182	233	6	a1	a1	NOUN
admet-182	233	7	)	)	PUNCT
admet-182	233	8	b(s	b(	NOUN
admet-182	233	9	)	)	PUNCT
admet-182	233	10			X
admet-182	233	11	b	b	X
admet-182	233	12	s0	s0	X
admet-182	233	13	=	=	PUNCT
admet-182	234	1	[	[	X
admet-182	234	2	b	b	X
admet-182	234	3	]	]	X
admet-182	234	4	(	(	PUNCT
admet-182	234	5	a2	a2	PROPN
admet-182	234	6	)	)	PUNCT
admet-182	234	7	solubility	solubility	NOUN
admet-182	234	8	,	,	PUNCT
admet-182	234	9	s	s	AUX
admet-182	234	10	,	,	PUNCT
admet-182	234	11	at	at	ADP
admet-182	234	12	a	a	DET
admet-182	234	13	particular	particular	ADJ
admet-182	234	14	ph	ph	NOUN
admet-182	234	15	is	be	AUX
admet-182	234	16	defined	define	VERB
admet-182	234	17	as	as	ADP
admet-182	234	18	the	the	DET
admet-182	234	19	mass	mass	NOUN
admet-182	234	20	balance	balance	NOUN
admet-182	234	21	sum	sum	NOUN
admet-182	234	22	of	of	ADP
admet-182	234	23	the	the	DET
admet-182	234	24	concentrations	concentration	NOUN
admet-182	234	25	of	of	ADP
admet-182	234	26	all	all	PRON
admet-182	234	27	of	of	ADP
admet-182	234	28	the	the	DET
admet-182	234	29	species	specie	NOUN
admet-182	234	30	dissolved	dissolve	VERB
admet-182	234	31	in	in	ADP
admet-182	234	32	the	the	DET
admet-182	234	33	aqueous	aqueous	ADJ
admet-182	234	34	phase	phase	NOUN
admet-182	234	35	:	:	PUNCT
admet-182	234	36	s	s	VERB
admet-182	234	37	=	=	PUNCT
admet-182	235	1	[	[	X
admet-182	235	2	b	b	X
admet-182	235	3	]	]	X
admet-182	235	4	+	+	CCONJ
admet-182	235	5	[	[	X
admet-182	235	6	bh+	bh+	NOUN
admet-182	235	7	]	]	PUNCT
admet-182	235	8	(	(	PUNCT
admet-182	235	9	a3	a3	NOUN
admet-182	235	10	)	)	PUNCT
admet-182	235	11	where	where	SCONJ
admet-182	235	12	the	the	DET
admet-182	235	13	square	square	ADJ
admet-182	235	14	brackets	bracket	NOUN
admet-182	235	15	denote	denote	VERB
admet-182	235	16	molar	molar	ADJ
admet-182	235	17	concentration	concentration	NOUN
admet-182	235	18	of	of	ADP
admet-182	235	19	species	specie	NOUN
admet-182	235	20	.	.	PUNCT
admet-182	236	1	the	the	DET
admet-182	236	2	above	above	ADJ
admet-182	236	3	equation	equation	NOUN
admet-182	236	4	can	can	AUX
admet-182	236	5	be	be	AUX
admet-182	236	6	transformed	transform	VERB
admet-182	236	7	into	into	ADP
admet-182	236	8	an	an	DET
admet-182	236	9	expression	expression	NOUN
admet-182	236	10	containing	contain	VERB
admet-182	236	11	only	only	ADJ
admet-182	236	12	constants	constant	NOUN
admet-182	236	13	and	and	CCONJ
admet-182	236	14	[	[	X
admet-182	236	15	h	h	NOUN
admet-182	237	1	+	+	X
admet-182	237	2	]	]	PUNCT
admet-182	237	3	(	(	PUNCT
admet-182	237	4	as	as	ADP
admet-182	237	5	the	the	DET
admet-182	237	6	only	only	ADJ
admet-182	237	7	variable	variable	NOUN
admet-182	237	8	)	)	PUNCT
admet-182	237	9	,	,	PUNCT
admet-182	237	10	by	by	ADP
admet-182	237	11	substituting	substitute	VERB
admet-182	237	12	the	the	DET
admet-182	237	13	ionization	ionization	NOUN
admet-182	237	14	and	and	CCONJ
admet-182	237	15	solubility	solubility	NOUN
admet-182	237	16	eqs	eqs	PROPN
admet-182	237	17	.	.	PUNCT
admet-182	238	1	(	(	PUNCT
admet-182	238	2	a1	a1	NOUN
admet-182	238	3	)	)	PUNCT
admet-182	238	4	and	and	CCONJ
admet-182	238	5	(	(	PUNCT
admet-182	238	6	a2	a2	PROPN
admet-182	238	7	)	)	PUNCT
admet-182	238	8	into	into	ADP
admet-182	238	9	eq	eq	NOUN
admet-182	238	10	.	.	PUNCT
admet-182	239	1	(	(	PUNCT
admet-182	239	2	a3	a3	NOUN
admet-182	239	3	)	)	PUNCT
admet-182	239	4	.	.	PUNCT
admet-182	240	1	log	log	PROPN
admet-182	240	2	s	s	PART
admet-182	240	3	=	=	NOUN
admet-182	240	4	log	log	NOUN
admet-182	240	5	(	(	PUNCT
admet-182	240	6	[	[	X
admet-182	240	7	b	b	X
admet-182	240	8	]	]	X
admet-182	240	9	+	+	CCONJ
admet-182	241	1	[	[	X
admet-182	241	2	h+][b	h+][b	X
admet-182	241	3	]	]	X
admet-182	241	4	/ka	/ka	PUNCT
admet-182	241	5	)	)	PUNCT
admet-182	241	6	=	=	PUNCT
admet-182	241	7	log	log	VERB
admet-182	242	1	[	[	X
admet-182	242	2	b	b	X
admet-182	242	3	]	]	X
admet-182	243	1	+	+	CCONJ
admet-182	243	2	log	log	NOUN
admet-182	243	3	(	(	PUNCT
admet-182	243	4	1	1	NUM
admet-182	243	5	+	+	CCONJ
admet-182	243	6	[	[	X
admet-182	243	7	h+	h+	X
admet-182	243	8	]	]	X
admet-182	243	9	/	/	SYM
admet-182	243	10	ka	ka	PROPN
admet-182	243	11	)	)	PUNCT
admet-182	244	1	=	=	PUNCT
admet-182	244	2	log	log	NOUN
admet-182	244	3	s0	s0	NOUN
admet-182	244	4	+	+	CCONJ
admet-182	244	5	log	log	NOUN
admet-182	244	6	(	(	PUNCT
admet-182	244	7	1	1	NUM
admet-182	244	8	+	+	NUM
admet-182	244	9	10	10	NUM
admet-182	244	10	+	+	ADJ
admet-182	244	11	pka	pka	X
admet-182	244	12	–	–	PUNCT
admet-182	244	13	ph	ph	NOUN
admet-182	244	14	)	)	PUNCT
admet-182	244	15	(	(	PUNCT
admet-182	244	16	a4	a4	NOUN
admet-182	244	17	)	)	PUNCT
admet-182	244	18	eq	eq	NOUN
admet-182	244	19	.	.	PUNCT
admet-182	245	1	(	(	PUNCT
admet-182	245	2	a4	a4	NOUN
admet-182	245	3	)	)	PUNCT
admet-182	245	4	is	be	AUX
admet-182	245	5	usually	usually	ADV
admet-182	245	6	called	call	VERB
admet-182	245	7	the	the	DET
admet-182	245	8	henderson	henderson	PROPN
admet-182	245	9	-	-	PUNCT
admet-182	245	10	hasselbalch	hasselbalch	PROPN
admet-182	245	11	equation	equation	NOUN
admet-182	245	12	for	for	ADP
admet-182	245	13	a	a	DET
admet-182	245	14	monoprotic	monoprotic	ADJ
admet-182	245	15	weak	weak	ADJ
admet-182	245	16	base	base	NOUN
admet-182	245	17	,	,	PUNCT
admet-182	245	18	and	and	CCONJ
admet-182	245	19	describes	describe	VERB
admet-182	245	20	a	a	DET
admet-182	245	21	hyperbolic	hyperbolic	ADV
admet-182	245	22	-	-	PUNCT
admet-182	245	23	shaped	shape	VERB
admet-182	245	24	log	log	NOUN
admet-182	245	25	s	s	PART
admet-182	245	26	–	–	PUNCT
admet-182	245	27	ph	ph	NOUN
admet-182	245	28	curve	curve	NOUN
admet-182	245	29	.	.	PUNCT
admet-182	246	1	at	at	ADP
admet-182	246	2	the	the	DET
admet-182	246	3	bend	bend	NOUN
admet-182	246	4	in	in	ADP
admet-182	246	5	the	the	DET
admet-182	246	6	log	log	NOUN
admet-182	246	7	s	s	PART
admet-182	246	8	–	–	PUNCT
admet-182	246	9	ph	ph	NOUN
admet-182	246	10	curve	curve	NOUN
admet-182	246	11	,	,	PUNCT
admet-182	246	12	the	the	DET
admet-182	246	13	ph	ph	NOUN
admet-182	246	14	equals	equal	VERB
admet-182	246	15	the	the	DET
admet-182	246	16	pka	pka	NOUN
admet-182	246	17	.	.	PUNCT
admet-182	247	1	it	it	PRON
admet-182	247	2	can	can	AUX
admet-182	247	3	be	be	AUX
admet-182	247	4	hypothesized	hypothesize	VERB
admet-182	247	5	that	that	SCONJ
admet-182	247	6	the	the	DET
admet-182	247	7	dimeric	dimeric	ADJ
admet-182	247	8	mixed	mix	VERB
admet-182	247	9	-	-	PUNCT
admet-182	247	10	charge	charge	NOUN
admet-182	247	11	weak	weak	ADJ
admet-182	247	12	base	base	NOUN
admet-182	247	13	species	specie	NOUN
admet-182	247	14	,	,	PUNCT
admet-182	247	15	(	(	PUNCT
admet-182	247	16	b.bh+	b.bh+	NOUN
admet-182	247	17	)	)	PUNCT
admet-182	247	18	,	,	PUNCT
admet-182	247	19	also	also	ADV
admet-182	247	20	forms	form	NOUN
admet-182	247	21	,	,	PUNCT
admet-182	247	22	which	which	PRON
admet-182	247	23	contains	contain	VERB
admet-182	247	24	a	a	DET
admet-182	247	25	1:1	1:1	NUM
admet-182	247	26	ratio	ratio	NOUN
admet-182	247	27	of	of	ADP
admet-182	247	28	b	b	NOUN
admet-182	247	29	and	and	CCONJ
admet-182	247	30	bh	bh	NOUN
admet-182	248	1	+	+	X
admet-182	248	2	.	.	PUNCT
admet-182	249	1	an	an	DET
admet-182	249	2	additional	additional	ADJ
admet-182	249	3	equilibrium	equilibrium	NOUN
admet-182	249	4	equation	equation	NOUN
admet-182	249	5	needs	need	VERB
admet-182	249	6	to	to	PART
admet-182	249	7	be	be	AUX
admet-182	249	8	added	add	VERB
admet-182	249	9	to	to	ADP
admet-182	249	10	the	the	DET
admet-182	249	11	mass	mass	NOUN
admet-182	249	12	balance	balance	NOUN
admet-182	249	13	.	.	PUNCT
admet-182	250	1	b	b	NOUN
admet-182	251	1	+	+	NUM
admet-182	251	2	bh+	bh+	NOUN
admet-182	251	3			NOUN
admet-182	251	4	(	(	PUNCT
admet-182	251	5	b.bh+	b.bh+	NOUN
admet-182	251	6	)	)	PUNCT
admet-182	251	7	k2	k2	NOUN
admet-182	251	8	=	=	PUNCT
admet-182	252	1	[	[	X
admet-182	252	2	b.bh+	b.bh+	NOUN
admet-182	252	3	]	]	PUNCT
admet-182	252	4	/	/	SYM
admet-182	253	1	[	[	X
admet-182	253	2	b][bh+	b][bh+	NOUN
admet-182	253	3	]	]	X
admet-182	253	4	(	(	PUNCT
admet-182	253	5	a5	a5	PROPN
admet-182	253	6	)	)	PUNCT
admet-182	253	7	eq	eq	NOUN
admet-182	253	8	.	.	PUNCT
admet-182	253	9	(	(	PUNCT
admet-182	253	10	a3	a3	NOUN
admet-182	253	11	)	)	PUNCT
admet-182	253	12	needs	need	VERB
admet-182	253	13	to	to	PART
admet-182	253	14	be	be	AUX
admet-182	253	15	expanded	expand	VERB
admet-182	253	16	accordingly	accordingly	ADV
admet-182	253	17	.	.	PUNCT
admet-182	254	1	s	s	PART
admet-182	255	1	=	=	PUNCT
admet-182	256	1	[	[	X
admet-182	256	2	b	b	X
admet-182	256	3	]	]	X
admet-182	256	4	+	+	CCONJ
admet-182	257	1	[	[	X
admet-182	257	2	bh	bh	NOUN
admet-182	257	3	+	+	X
admet-182	257	4	]	]	PUNCT
admet-182	257	5	+	+	CCONJ
admet-182	257	6	2	2	NUM
admet-182	257	7	[	[	X
admet-182	257	8	b.bh	b.bh	X
admet-182	257	9	+	+	X
admet-182	257	10	]	]	PUNCT
admet-182	257	11	(	(	PUNCT
admet-182	257	12	a6	a6	NOUN
admet-182	257	13	)	)	PUNCT
admet-182	257	14	in	in	ADP
admet-182	257	15	logarithmic	logarithmic	ADJ
admet-182	257	16	form	form	NOUN
admet-182	257	17	,	,	PUNCT
admet-182	257	18	log	log	PROPN
admet-182	257	19	s	s	PART
admet-182	257	20	=	=	NOUN
admet-182	257	21	log	log	NOUN
admet-182	257	22	(	(	PUNCT
admet-182	257	23	[	[	X
admet-182	257	24	b	b	X
admet-182	257	25	]	]	X
admet-182	257	26	+	+	CCONJ
admet-182	258	1	[	[	X
admet-182	258	2	h+][b	h+][b	X
admet-182	258	3	]	]	X
admet-182	258	4	/ka	/ka	PUNCT
admet-182	259	1	+	+	ADJ
admet-182	259	2	2	2	NUM
admet-182	259	3	k2[b][bh+	k2[b][bh+	NOUN
admet-182	259	4	]	]	X
admet-182	259	5	)	)	PUNCT
admet-182	259	6	=	=	SYM
admet-182	260	1	log	log	NOUN
admet-182	260	2	(	(	PUNCT
admet-182	260	3	[	[	X
admet-182	260	4	b	b	X
admet-182	260	5	]	]	X
admet-182	260	6	+	+	CCONJ
admet-182	261	1	[	[	X
admet-182	261	2	h+][b	h+][b	X
admet-182	261	3	]	]	X
admet-182	261	4	/ka	/ka	PUNCT
admet-182	261	5	+	+	CCONJ
admet-182	261	6	2	2	NUM
admet-182	261	7	k2[b]2	k2[b]2	NOUN
admet-182	261	8	[	[	X
admet-182	261	9	h+	h+	X
admet-182	261	10	]	]	X
admet-182	261	11	/ka	/ka	PUNCT
admet-182	261	12	)	)	PUNCT
admet-182	262	1	=	=	PUNCT
admet-182	262	2	log	log	NOUN
admet-182	262	3	s0	s0	NOUN
admet-182	262	4	+	+	CCONJ
admet-182	262	5	log	log	NOUN
admet-182	262	6	(	(	PUNCT
admet-182	262	7	1	1	NUM
admet-182	262	8	+	+	CCONJ
admet-182	262	9	{	{	PUNCT
admet-182	262	10	1	1	NUM
admet-182	262	11	+	+	SYM
admet-182	262	12	2	2	NUM
admet-182	262	13	k2	k2	ADJ
admet-182	262	14	s0	s0	PROPN
admet-182	262	15	}	}	PUNCT
admet-182	262	16	10	10	NUM
admet-182	263	1	+	+	X
admet-182	263	2	pka	pka	X
admet-182	263	3	–	–	PUNCT
admet-182	263	4	ph	ph	NOUN
admet-182	263	5	)	)	PUNCT
admet-182	263	6	(	(	PUNCT
admet-182	263	7	a7	a7	PROPN
admet-182	263	8	)	)	PUNCT
admet-182	263	9	for	for	ADP
admet-182	263	10	nsc-639829	nsc-639829	NOUN
admet-182	263	11	,	,	PUNCT
admet-182	263	12	the	the	DET
admet-182	263	13	factor	factor	NOUN
admet-182	263	14	in	in	ADP
admet-182	263	15	the	the	DET
admet-182	263	16	braces	brace	NOUN
admet-182	263	17	in	in	ADP
admet-182	263	18	eq	eq	ADP
admet-182	263	19	.	.	PUNCT
admet-182	264	1	(	(	PUNCT
admet-182	264	2	a7	a7	PROPN
admet-182	264	3	)	)	PUNCT
admet-182	264	4	equals	equal	VERB
admet-182	264	5	8.60	8.60	NUM
admet-182	264	6	(=	(=	NOUN
admet-182	264	7	1	1	NUM
admet-182	264	8	+	+	NUM
admet-182	264	9	2	2	NUM
admet-182	264	10	x	x	SYM
admet-182	264	11	10	10	NUM
admet-182	264	12	+	+	NOUN
admet-182	264	13	7.80	7.80	NUM
admet-182	264	14	x	x	SYM
admet-182	264	15	10	10	NUM
admet-182	264	16	-	-	NUM
admet-182	264	17	7.22	7.22	NUM
admet-182	264	18	)	)	PUNCT
admet-182	264	19	.	.	PUNCT
admet-182	265	1	when	when	SCONJ
admet-182	265	2	the	the	DET
admet-182	265	3	logarithm	logarithm	NOUN
admet-182	265	4	of	of	ADP
admet-182	265	5	the	the	DET
admet-182	265	6	factor	factor	NOUN
admet-182	265	7	(	(	PUNCT
admet-182	265	8	0.94	0.94	NUM
admet-182	265	9	)	)	PUNCT
admet-182	265	10	is	be	AUX
admet-182	265	11	taken	take	VERB
admet-182	265	12	into	into	ADP
admet-182	265	13	the	the	DET
admet-182	265	14	exponent	exponent	NOUN
admet-182	265	15	,	,	PUNCT
admet-182	265	16	the	the	DET
admet-182	265	17	resulting	result	VERB
admet-182	265	18	equation	equation	NOUN
admet-182	265	19	appears	appear	VERB
admet-182	265	20	to	to	PART
admet-182	265	21	equal	equal	VERB
admet-182	265	22	eq	eq	ADP
admet-182	265	23	.	.	PUNCT
admet-182	265	24	(	(	PUNCT
admet-182	265	25	a4	a4	NOUN
admet-182	265	26	)	)	PUNCT
admet-182	265	27	,	,	PUNCT
admet-182	265	28	except	except	SCONJ
admet-182	265	29	that	that	SCONJ
admet-182	265	30	the	the	DET
admet-182	265	31	pka	pka	PROPN
admet-182	265	32	is	be	AUX
admet-182	265	33	replaced	replace	VERB
admet-182	265	34	with	with	ADP
admet-182	265	35	the	the	DET
admet-182	265	36	sph	sph	PROPN
admet-182	265	37	-	-	PUNCT
admet-182	265	38	pka	pka	PROPN
admet-182	265	39	value	value	NOUN
admet-182	265	40	(	(	PUNCT
admet-182	265	41	3.76	3.76	NUM
admet-182	265	42	+	+	NUM
admet-182	265	43	0.94	0.94	NUM
admet-182	265	44	=	=	SYM
admet-182	265	45	4.70	4.70	NUM
admet-182	265	46	)	)	PUNCT
admet-182	265	47	.	.	PUNCT
admet-182	266	1	the	the	DET
admet-182	266	2	hypothesized	hypothesized	ADJ
admet-182	266	3	presence	presence	NOUN
admet-182	266	4	of	of	ADP
admet-182	266	5	the	the	DET
admet-182	266	6	mixed	mix	VERB
admet-182	266	7	-	-	PUNCT
admet-182	266	8	charge	charge	NOUN
admet-182	266	9	dimer	dimer	NOUN
admet-182	266	10	appears	appear	VERB
admet-182	266	11	to	to	PART
admet-182	266	12	shift	shift	VERB
admet-182	266	13	the	the	DET
admet-182	266	14	original	original	ADJ
admet-182	266	15	henderson	henderson	PROPN
admet-182	266	16	-	-	PUNCT
admet-182	266	17	hasselbalch	hasselbalch	PROPN
admet-182	266	18	equation	equation	NOUN
admet-182	266	19	in	in	ADP
admet-182	266	20	the	the	DET
admet-182	266	21	positive	positive	ADJ
admet-182	266	22	ph	ph	NOUN
admet-182	266	23	direction	direction	NOUN
admet-182	266	24	by	by	ADP
admet-182	266	25	nearly	nearly	ADV
admet-182	266	26	a	a	DET
admet-182	266	27	log	log	NOUN
admet-182	266	28	unit	unit	NOUN
admet-182	266	29	.	.	PUNCT
admet-182	267	1	the	the	DET
admet-182	267	2	presence	presence	NOUN
admet-182	267	3	of	of	ADP
admet-182	267	4	self	self	NOUN
admet-182	267	5	-	-	PUNCT
admet-182	267	6	aggregated	aggregate	VERB
admet-182	267	7	species	specie	NOUN
admet-182	267	8	of	of	ADP
admet-182	267	9	other	other	ADJ
admet-182	267	10	stoichiometries	stoichiometry	NOUN
admet-182	267	11	can	can	AUX
admet-182	267	12	distort	distort	VERB
admet-182	267	13	the	the	DET
admet-182	267	14	shape	shape	NOUN
admet-182	267	15	of	of	ADP
admet-182	267	16	the	the	DET
admet-182	267	17	simple	simple	ADJ
admet-182	267	18	henderson	henderson	PROPN
admet-182	267	19	-	-	PUNCT
admet-182	267	20	hasselbalch	hasselbalch	PROPN
admet-182	267	21	equation	equation	NOUN
admet-182	267	22	in	in	ADP
admet-182	267	23	a	a	DET
admet-182	267	24	number	number	NOUN
admet-182	267	25	of	of	ADP
admet-182	267	26	different	different	ADJ
admet-182	267	27	ways	way	NOUN
admet-182	268	1	[	[	X
admet-182	268	2	4,9,10,12,18	4,9,10,12,18	NOUN
admet-182	268	3	]	]	PUNCT
admet-182	268	4	.	.	PUNCT
admet-182	269	1	the	the	DET
admet-182	269	2	example	example	NOUN
admet-182	269	3	in	in	ADP
admet-182	269	4	the	the	DET
admet-182	269	5	present	present	ADJ
admet-182	269	6	study	study	NOUN
admet-182	269	7	is	be	AUX
admet-182	269	8	one	one	NUM
admet-182	269	9	of	of	ADP
admet-182	269	10	the	the	DET
admet-182	269	11	simpler	simple	ADJ
admet-182	269	12	types	type	NOUN
admet-182	269	13	of	of	ADP
admet-182	269	14	distortion	distortion	NOUN
admet-182	269	15	.	.	PUNCT
admet-182	270	1	with	with	ADP
admet-182	270	2	increasing	increase	VERB
admet-182	270	3	ph	ph	VERB
admet-182	270	4	,	,	PUNCT
admet-182	270	5	it	it	PRON
admet-182	270	6	is	be	AUX
admet-182	270	7	possible	possible	ADJ
admet-182	270	8	for	for	SCONJ
admet-182	270	9	the	the	DET
admet-182	270	10	protonated	protonate	VERB
admet-182	270	11	dimer	dimer	NOUN
admet-182	270	12	,	,	PUNCT
admet-182	270	13	b.bh+	b.bh+	NOUN
admet-182	270	14	,	,	PUNCT
admet-182	270	15	to	to	PART
admet-182	270	16	lose	lose	VERB
admet-182	270	17	the	the	DET
admet-182	270	18	ionizable	ionizable	ADJ
admet-182	270	19	proton	proton	NOUN
admet-182	270	20	to	to	PART
admet-182	270	21	become	become	VERB
admet-182	270	22	the	the	DET
admet-182	270	23	water	water	NOUN
admet-182	270	24	-	-	PUNCT
admet-182	270	25	soluble	soluble	ADJ
admet-182	270	26	neutral	neutral	ADJ
admet-182	270	27	-	-	PUNCT
admet-182	270	28	species	specie	NOUN
admet-182	270	29	dimer	dimer	NOUN
admet-182	270	30	,	,	PUNCT
admet-182	270	31	b2	b2	NOUN
admet-182	270	32	.	.	PUNCT
admet-182	271	1	the	the	DET
admet-182	271	2	pka	pka	PROPN
admet-182	271	3	for	for	ADP
admet-182	271	4	such	such	DET
admet-182	271	5	a	a	DET
admet-182	271	6	process	process	NOUN
admet-182	271	7	would	would	AUX
admet-182	271	8	not	not	PART
admet-182	271	9	be	be	AUX
admet-182	271	10	expected	expect	VERB
admet-182	271	11	to	to	PART
admet-182	271	12	be	be	AUX
admet-182	271	13	exactly	exactly	ADV
admet-182	271	14	the	the	DET
admet-182	271	15	same	same	ADJ
admet-182	271	16	as	as	ADP
admet-182	271	17	the	the	DET
admet-182	271	18	measured	measured	ADJ
admet-182	271	19	pka	pka	PROPN
admet-182	271	20	.	.	PUNCT
admet-182	272	1	for	for	ADP
admet-182	272	2	example	example	NOUN
admet-182	272	3	,	,	PUNCT
admet-182	272	4	ketoprofen	ketoprofen	VERB
admet-182	272	5	bound	bind	VERB
admet-182	272	6	to	to	ADP
admet-182	272	7	sodium	sodium	NOUN
admet-182	272	8	taurocholate	taurocholate	NOUN
admet-182	272	9	butcher	butcher	NOUN
admet-182	272	10	,	,	PUNCT
admet-182	272	11	comer	comer	NOUN
admet-182	272	12	,	,	PUNCT
admet-182	272	13	avdeef	avdeef	NOUN
admet-182	272	14	admet	admet	PROPN
admet-182	272	15	&	&	CCONJ
admet-182	272	16	dmpk	dmpk	PROPN
admet-182	272	17	3(2	3(2	NUM
admet-182	272	18	)	)	PUNCT
admet-182	272	19	(	(	PUNCT
admet-182	272	20	2015	2015	NUM
admet-182	272	21	)	)	PUNCT
admet-182	272	22	131	131	NUM
admet-182	272	23	-	-	SYM
admet-182	272	24	140	140	NUM
admet-182	272	25	140	140	NUM
admet-182	272	26	micelles	micelle	NOUN
admet-182	272	27	shows	show	VERB
admet-182	272	28	such	such	DET
admet-182	272	29	a	a	DET
admet-182	272	30	secondary	secondary	ADJ
admet-182	272	31	pka	pka	NOUN
admet-182	273	1	[	[	X
admet-182	273	2	9	9	NUM
admet-182	273	3	]	]	PUNCT
admet-182	273	4	.	.	PUNCT
admet-182	274	1	there	there	PRON
admet-182	274	2	was	be	VERB
admet-182	274	3	no	no	DET
admet-182	274	4	hint	hint	NOUN
admet-182	274	5	of	of	ADP
admet-182	274	6	such	such	DET
admet-182	274	7	a	a	DET
admet-182	274	8	process	process	NOUN
admet-182	274	9	in	in	ADP
admet-182	274	10	the	the	DET
admet-182	274	11	case	case	NOUN
admet-182	274	12	of	of	ADP
admet-182	274	13	nsc-639829	nsc-639829	NOUN
admet-182	274	14	,	,	PUNCT
admet-182	274	15	but	but	CCONJ
admet-182	274	16	a	a	DET
admet-182	274	17	more	more	ADV
admet-182	274	18	thorough	thorough	ADJ
admet-182	274	19	investigation	investigation	NOUN
admet-182	274	20	would	would	AUX
admet-182	274	21	require	require	VERB
admet-182	274	22	additional	additional	ADJ
admet-182	274	23	log	log	NOUN
admet-182	274	24	s	s	NOUN
admet-182	274	25	-	-	PUNCT
admet-182	274	26	ph	ph	ADJ
admet-182	274	27	measurements	measurement	NOUN
admet-182	274	28	with	with	ADP
admet-182	274	29	total	total	ADJ
admet-182	274	30	concentration	concentration	NOUN
admet-182	274	31	of	of	ADP
admet-182	274	32	the	the	DET
admet-182	274	33	sample	sample	NOUN
admet-182	274	34	varied	varied	ADJ
admet-182	274	35	over	over	ADP
admet-182	274	36	a	a	DET
admet-182	274	37	wide	wide	ADJ
admet-182	274	38	range	range	NOUN
admet-182	274	39	,	,	PUNCT
admet-182	274	40	since	since	SCONJ
admet-182	274	41	aggregates	aggregate	NOUN
admet-182	274	42	would	would	AUX
admet-182	274	43	be	be	AUX
admet-182	274	44	expected	expect	VERB
admet-182	274	45	to	to	PART
admet-182	274	46	have	have	VERB
admet-182	274	47	concentration	concentration	NOUN
admet-182	274	48	dependence	dependence	NOUN
admet-182	274	49	.	.	PUNCT
admet-182	275	1	©	©	X
admet-182	275	2	2015	2015	NUM
admet-182	275	3	by	by	ADP
admet-182	275	4	the	the	DET
admet-182	275	5	authors	author	NOUN
admet-182	275	6	;	;	PUNCT
admet-182	275	7	licensee	licensee	PROPN
admet-182	275	8	iapc	iapc	PROPN
admet-182	275	9	,	,	PUNCT
admet-182	275	10	zagreb	zagreb	PROPN
admet-182	275	11	,	,	PUNCT
admet-182	275	12	croatia	croatia	PROPN
admet-182	275	13	.	.	PUNCT
admet-182	276	1	this	this	DET
admet-182	276	2	article	article	NOUN
admet-182	276	3	is	be	AUX
admet-182	276	4	an	an	DET
admet-182	276	5	open	open	ADJ
admet-182	276	6	-	-	PUNCT
admet-182	276	7	access	access	NOUN
admet-182	276	8	article	article	NOUN
admet-182	276	9	distributed	distribute	VERB
admet-182	276	10	under	under	ADP
admet-182	276	11	the	the	DET
admet-182	276	12	terms	term	NOUN
admet-182	276	13	and	and	CCONJ
admet-182	276	14	conditions	condition	NOUN
admet-182	276	15	of	of	ADP
admet-182	276	16	the	the	DET
admet-182	276	17	creative	creative	ADJ
admet-182	276	18	commons	common	NOUN
admet-182	276	19	attribution	attribution	NOUN
admet-182	276	20	license	license	NOUN
admet-182	276	21	(	(	PUNCT
admet-182	276	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-182	276	23	)	)	PUNCT
admet-182	276	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN