id	sid	tid	token	lemma	pos
admet-184	1	1	doi	doi	NOUN
admet-184	1	2	:	:	PUNCT
admet-184	1	3	10.5599	10.5599	NUM
admet-184	1	4	/	/	SYM
admet-184	1	5	admet.3.3.184	admet.3.3.184	NUM
admet-184	1	6	190	190	NUM
admet-184	1	7	admet	admet	X
admet-184	1	8	&	&	CCONJ
admet-184	1	9	dmpk	dmpk	PROPN
admet-184	1	10	3(3	3(3	NUM
admet-184	1	11	)	)	PUNCT
admet-184	1	12	(	(	PUNCT
admet-184	1	13	2015	2015	NUM
admet-184	1	14	)	)	PUNCT
admet-184	1	15	190	190	NUM
admet-184	1	16	-	-	SYM
admet-184	1	17	202	202	NUM
admet-184	1	18	;	;	PUNCT
admet-184	1	19	doi	doi	NOUN
admet-184	1	20	:	:	PUNCT
admet-184	1	21	10.5599	10.5599	NUM
admet-184	1	22	/	/	SYM
admet-184	1	23	admet.3.3.184	admet.3.3.184	NUM
admet-184	1	24	open	open	ADJ
admet-184	1	25	access	access	NOUN
admet-184	1	26	:	:	PUNCT
admet-184	1	27	issn	issn	PROPN
admet-184	1	28	:	:	PUNCT
admet-184	1	29	1848	1848	NUM
admet-184	1	30	-	-	SYM
admet-184	1	31	7718	7718	NUM
admet-184	1	32	review	review	NOUN
admet-184	1	33	nose	nose	NOUN
admet-184	1	34	-	-	PUNCT
admet-184	1	35	to	to	ADP
admet-184	1	36	-	-	PUNCT
admet-184	1	37	brain	brain	NOUN
admet-184	1	38	delivery	delivery	NOUN
admet-184	1	39	of	of	ADP
admet-184	1	40	insulin	insulin	NOUN
admet-184	1	41	for	for	ADP
admet-184	1	42	alzheimer	alzheimer	PROPN
admet-184	1	43	’s	’s	PART
admet-184	1	44	disease	disease	NOUN
admet-184	1	45	martina	martina	PROPN
admet-184	1	46	stützle1,2,3	stützle1,2,3	PROPN
admet-184	1	47	,	,	PUNCT
admet-184	1	48	johannes	johannes	PROPN
admet-184	1	49	flamm1,3	flamm1,3	PROPN
admet-184	1	50	,	,	PUNCT
admet-184	1	51	stefan	stefan	PROPN
admet-184	1	52	carle1,3	carle1,3	PROPN
admet-184	1	53	and	and	CCONJ
admet-184	1	54	katharina	katharina	PROPN
admet-184	1	55	schindowski1,3	schindowski1,3	PROPN
admet-184	1	56	*	*	PROPN
admet-184	1	57	1	1	NUM
admet-184	1	58	institute	institute	NOUN
admet-184	1	59	of	of	ADP
admet-184	1	60	applied	apply	VERB
admet-184	1	61	biotechnlogy	biotechnlogy	NOUN
admet-184	1	62	,	,	PUNCT
admet-184	1	63	dept	dept	NOUN
admet-184	1	64	.	.	PUNCT
admet-184	2	1	for	for	ADP
admet-184	2	2	molecular	molecular	ADJ
admet-184	2	3	pharmacology	pharmacology	NOUN
admet-184	2	4	,	,	PUNCT
admet-184	2	5	biberach	biberach	NOUN
admet-184	2	6	university	university	NOUN
admet-184	2	7	of	of	ADP
admet-184	2	8	applied	apply	VERB
admet-184	2	9	science	science	NOUN
admet-184	2	10	,	,	PUNCT
admet-184	2	11	karlstrasse	karlstrasse	NOUN
admet-184	2	12	11	11	NUM
admet-184	2	13	,	,	PUNCT
admet-184	2	14	d-88400	d-88400	NOUN
admet-184	2	15	biberach	biberach	NOUN
admet-184	2	16	/	/	SYM
admet-184	2	17	riss	riss	PROPN
admet-184	2	18	,	,	PUNCT
admet-184	2	19	germany	germany	PROPN
admet-184	2	20	2	2	NUM
admet-184	2	21	faculty	faculty	NOUN
admet-184	2	22	of	of	ADP
admet-184	2	23	medicine	medicine	NOUN
admet-184	2	24	,	,	PUNCT
admet-184	2	25	university	university	NOUN
admet-184	2	26	of	of	ADP
admet-184	2	27	ulm	ulm	PROPN
admet-184	2	28	,	,	PUNCT
admet-184	2	29	albert	albert	PROPN
admet-184	2	30	-	-	PUNCT
admet-184	2	31	einstein	einstein	NOUN
admet-184	2	32	-	-	PUNCT
admet-184	2	33	allee	allee	NOUN
admet-184	2	34	11	11	NUM
admet-184	2	35	,	,	PUNCT
admet-184	2	36	d-89081	d-89081	PROPN
admet-184	2	37	ulm	ulm	PROPN
admet-184	2	38	,	,	PUNCT
admet-184	2	39	germany	germany	PROPN
admet-184	2	40	3	3	NUM
admet-184	2	41	faculty	faculty	NOUN
admet-184	2	42	of	of	ADP
admet-184	2	43	natural	natural	ADJ
admet-184	2	44	science	science	NOUN
admet-184	2	45	,	,	PUNCT
admet-184	2	46	university	university	NOUN
admet-184	2	47	of	of	ADP
admet-184	2	48	ulm	ulm	PROPN
admet-184	2	49	,	,	PUNCT
admet-184	2	50	albert	albert	PROPN
admet-184	2	51	-	-	PUNCT
admet-184	2	52	einstein	einstein	NOUN
admet-184	2	53	-	-	PUNCT
admet-184	2	54	allee	allee	NOUN
admet-184	2	55	11	11	NUM
admet-184	2	56	,	,	PUNCT
admet-184	2	57	d-89081	d-89081	PROPN
admet-184	2	58	ulm	ulm	PROPN
admet-184	2	59	,	,	PUNCT
admet-184	2	60	germany	germany	PROPN
admet-184	2	61	*	*	PUNCT
admet-184	2	62	corresponding	correspond	VERB
admet-184	2	63	author	author	NOUN
admet-184	2	64	:	:	PUNCT
admet-184	2	65	e	e	NOUN
admet-184	2	66	-	-	NOUN
admet-184	2	67	mail	mail	NOUN
admet-184	2	68	:	:	PUNCT
admet-184	2	69	zimmermann@hochschule-bc.de	zimmermann@hochschule-bc.de	NUM
admet-184	2	70	,	,	PUNCT
admet-184	2	71	tel	tel	PROPN
admet-184	2	72	.	.	PUNCT
admet-184	2	73	:	:	PUNCT
admet-184	3	1	+49	+49	NOUN
admet-184	3	2	-	-	PUNCT
admet-184	3	3	7351	7351	NUM
admet-184	3	4	-	-	SYM
admet-184	3	5	582	582	NUM
admet-184	3	6	498	498	NUM
admet-184	3	7	received	receive	VERB
admet-184	3	8	:	:	PUNCT
admet-184	3	9	may	may	AUX
admet-184	3	10	04	04	NUM
admet-184	3	11	,	,	PUNCT
admet-184	3	12	2015	2015	NUM
admet-184	3	13	;	;	PUNCT
admet-184	3	14	revised	revise	VERB
admet-184	3	15	:	:	PUNCT
admet-184	3	16	august	august	PROPN
admet-184	3	17	04	04	NUM
admet-184	3	18	,	,	PUNCT
admet-184	3	19	2015	2015	NUM
admet-184	3	20	;	;	PUNCT
admet-184	3	21	published	publish	VERB
admet-184	3	22	:	:	PUNCT
admet-184	3	23	september	september	PROPN
admet-184	3	24	05	05	NUM
admet-184	3	25	,	,	PUNCT
admet-184	3	26	2015	2015	NUM
admet-184	3	27	abstract	abstract	NOUN
admet-184	3	28	the	the	DET
admet-184	3	29	transport	transport	NOUN
admet-184	3	30	of	of	ADP
admet-184	3	31	small	small	ADJ
admet-184	3	32	molecules	molecule	NOUN
admet-184	3	33	,	,	PUNCT
admet-184	3	34	peptides	peptide	NOUN
admet-184	3	35	and	and	CCONJ
admet-184	3	36	proteins	protein	NOUN
admet-184	3	37	via	via	ADP
admet-184	3	38	the	the	DET
admet-184	3	39	olfactory	olfactory	NOUN
admet-184	3	40	epithelium	epithelium	NOUN
admet-184	3	41	and	and	CCONJ
admet-184	3	42	along	along	ADP
admet-184	3	43	olfactory	olfactory	NOUN
admet-184	3	44	and	and	CCONJ
admet-184	3	45	trigeminal	trigeminal	ADJ
admet-184	3	46	nerve	nerve	NOUN
admet-184	3	47	pathways	pathway	NOUN
admet-184	3	48	from	from	ADP
admet-184	3	49	the	the	DET
admet-184	3	50	nasal	nasal	ADJ
admet-184	3	51	cavity	cavity	NOUN
admet-184	3	52	to	to	ADP
admet-184	3	53	the	the	DET
admet-184	3	54	brain	brain	NOUN
admet-184	3	55	is	be	AUX
admet-184	3	56	very	very	ADV
admet-184	3	57	well	well	ADV
admet-184	3	58	known	know	VERB
admet-184	3	59	and	and	CCONJ
admet-184	3	60	clinically	clinically	ADV
admet-184	3	61	established	establish	VERB
admet-184	3	62	for	for	ADP
admet-184	3	63	central	central	ADJ
admet-184	3	64	nervous	nervous	ADJ
admet-184	3	65	system	system	NOUN
admet-184	3	66	(	(	PUNCT
admet-184	3	67	cns	cns	NOUN
admet-184	3	68	)	)	PUNCT
admet-184	3	69	active	active	ADJ
admet-184	3	70	drugs	drug	NOUN
admet-184	3	71	like	like	ADP
admet-184	3	72	oxytocin	oxytocin	PROPN
admet-184	3	73	,	,	PUNCT
admet-184	3	74	sumatriptan	sumatriptan	ADJ
admet-184	3	75	or	or	CCONJ
admet-184	3	76	insulin	insulin	NOUN
admet-184	3	77	.	.	PUNCT
admet-184	4	1	insulin	insulin	NOUN
admet-184	4	2	is	be	AUX
admet-184	4	3	a	a	DET
admet-184	4	4	clinically	clinically	ADV
admet-184	4	5	well	well	ADV
admet-184	4	6	-	-	PUNCT
admet-184	4	7	established	establish	VERB
admet-184	4	8	biopharmaceutical	biopharmaceutical	NOUN
admet-184	4	9	with	with	ADP
admet-184	4	10	a	a	DET
admet-184	4	11	validated	validate	VERB
admet-184	4	12	function	function	NOUN
admet-184	4	13	in	in	ADP
admet-184	4	14	cognition	cognition	NOUN
admet-184	4	15	.	.	PUNCT
admet-184	5	1	central	central	ADJ
admet-184	5	2	supply	supply	NOUN
admet-184	5	3	with	with	ADP
admet-184	5	4	insulin	insulin	NOUN
admet-184	5	5	via	via	ADP
admet-184	5	6	intranasal	intranasal	NOUN
admet-184	5	7	administration	administration	NOUN
admet-184	5	8	improves	improve	VERB
admet-184	5	9	cognition	cognition	NOUN
admet-184	5	10	in	in	ADP
admet-184	5	11	animal	animal	NOUN
admet-184	5	12	models	model	NOUN
admet-184	5	13	and	and	CCONJ
admet-184	5	14	in	in	ADP
admet-184	5	15	human	human	NOUN
admet-184	5	16	,	,	PUNCT
admet-184	5	17	making	make	VERB
admet-184	5	18	insulin	insulin	NOUN
admet-184	5	19	a	a	DET
admet-184	5	20	so	so	ADV
admet-184	5	21	-	-	PUNCT
admet-184	5	22	called	call	VERB
admet-184	5	23	cognitive	cognitive	ADJ
admet-184	5	24	enhancer	enhancer	NOUN
admet-184	5	25	.	.	PUNCT
admet-184	6	1	furthermore	furthermore	ADV
admet-184	6	2	,	,	PUNCT
admet-184	6	3	dysregulation	dysregulation	NOUN
admet-184	6	4	of	of	ADP
admet-184	6	5	insulin	insulin	NOUN
admet-184	6	6	is	be	AUX
admet-184	6	7	implicated	implicate	VERB
admet-184	6	8	in	in	ADP
admet-184	6	9	the	the	DET
admet-184	6	10	pathogenesis	pathogenesis	NOUN
admet-184	6	11	of	of	ADP
admet-184	6	12	alzheimer	alzheimer	PROPN
admet-184	6	13	’s	’s	PART
admet-184	6	14	disease	disease	NOUN
admet-184	6	15	,	,	PUNCT
admet-184	6	16	which	which	PRON
admet-184	6	17	is	be	AUX
admet-184	6	18	associated	associate	VERB
admet-184	6	19	with	with	ADP
admet-184	6	20	lower	low	ADJ
admet-184	6	21	levels	level	NOUN
admet-184	6	22	of	of	ADP
admet-184	6	23	insulin	insulin	NOUN
admet-184	6	24	in	in	ADP
admet-184	6	25	the	the	DET
admet-184	6	26	cerebrospinal	cerebrospinal	ADJ
admet-184	6	27	fluid	fluid	NOUN
admet-184	6	28	and	and	CCONJ
admet-184	6	29	is	be	AUX
admet-184	6	30	involved	involve	VERB
admet-184	6	31	in	in	ADP
admet-184	6	32	amyloid	amyloid	NOUN
admet-184	6	33	-	-	PUNCT
admet-184	6	34	beta	beta	NOUN
admet-184	6	35	(	(	PUNCT
admet-184	6	36	a	a	NOUN
admet-184	6	37	)	)	PUNCT
admet-184	6	38	regulation	regulation	NOUN
admet-184	6	39	.	.	PUNCT
admet-184	7	1	clinical	clinical	ADJ
admet-184	7	2	trials	trial	NOUN
admet-184	7	3	with	with	ADP
admet-184	7	4	intranasal	intranasal	ADJ
admet-184	7	5	insulin	insulin	NOUN
admet-184	7	6	implicate	implicate	VERB
admet-184	7	7	positive	positive	ADJ
admet-184	7	8	effects	effect	NOUN
admet-184	7	9	on	on	ADP
admet-184	7	10	learning	learning	NOUN
admet-184	7	11	and	and	CCONJ
admet-184	7	12	memory	memory	NOUN
admet-184	7	13	,	,	PUNCT
admet-184	7	14	but	but	CCONJ
admet-184	7	15	a	a	DET
admet-184	7	16	massive	massive	ADJ
admet-184	7	17	lack	lack	NOUN
admet-184	7	18	of	of	ADP
admet-184	7	19	pharmacokinetic	pharmacokinetic	ADJ
admet-184	7	20	and	and	CCONJ
admet-184	7	21	efficacy	efficacy	NOUN
admet-184	7	22	data	datum	NOUN
admet-184	7	23	hamper	hamper	VERB
admet-184	7	24	a	a	DET
admet-184	7	25	pharmacokinetic	pharmacokinetic	ADJ
admet-184	7	26	–	–	PUNCT
admet-184	7	27	pharmcodynamic	pharmcodynamic	NOUN
admet-184	7	28	relation	relation	NOUN
admet-184	7	29	and	and	CCONJ
admet-184	7	30	a	a	DET
admet-184	7	31	possible	possible	ADJ
admet-184	7	32	clinical	clinical	ADJ
admet-184	7	33	development	development	NOUN
admet-184	7	34	as	as	ADP
admet-184	7	35	cognition	cognition	NOUN
admet-184	7	36	enhancer	enhancer	NOUN
admet-184	7	37	.	.	PUNCT
admet-184	8	1	a	a	DET
admet-184	8	2	lack	lack	NOUN
admet-184	8	3	of	of	ADP
admet-184	8	4	such	such	ADJ
admet-184	8	5	data	datum	NOUN
admet-184	8	6	also	also	ADV
admet-184	8	7	prevents	prevent	VERB
admet-184	8	8	resolving	resolve	VERB
admet-184	8	9	the	the	DET
admet-184	8	10	mechanisms	mechanism	NOUN
admet-184	8	11	involved	involve	VERB
admet-184	8	12	in	in	ADP
admet-184	8	13	directing	direct	VERB
admet-184	8	14	insulin	insulin	NOUN
admet-184	8	15	to	to	ADP
admet-184	8	16	the	the	DET
admet-184	8	17	central	central	ADJ
admet-184	8	18	or	or	CCONJ
admet-184	8	19	to	to	ADP
admet-184	8	20	the	the	DET
admet-184	8	21	peripheral	peripheral	ADJ
admet-184	8	22	compartment	compartment	NOUN
admet-184	8	23	.	.	PUNCT
admet-184	9	1	here	here	ADV
admet-184	9	2	we	we	PRON
admet-184	9	3	discuss	discuss	VERB
admet-184	9	4	the	the	DET
admet-184	9	5	basic	basic	ADJ
admet-184	9	6	mechanism	mechanism	NOUN
admet-184	9	7	of	of	ADP
admet-184	9	8	nose	nose	NOUN
admet-184	9	9	-	-	PUNCT
admet-184	9	10	to	to	ADP
admet-184	9	11	-	-	PUNCT
admet-184	9	12	brain	brain	NOUN
admet-184	9	13	delivery	delivery	NOUN
admet-184	9	14	,	,	PUNCT
admet-184	9	15	evidences	evidence	NOUN
admet-184	9	16	for	for	ADP
admet-184	9	17	intranasal	intranasal	ADJ
admet-184	9	18	insulin	insulin	NOUN
admet-184	9	19	as	as	ADP
admet-184	9	20	cognition	cognition	NOUN
admet-184	9	21	enhancer	enhancer	NOUN
admet-184	9	22	,	,	PUNCT
admet-184	9	23	medical	medical	ADJ
admet-184	9	24	devices	device	NOUN
admet-184	9	25	for	for	ADP
admet-184	9	26	intranasal	intranasal	ADJ
admet-184	9	27	delivery	delivery	NOUN
admet-184	9	28	and	and	CCONJ
admet-184	9	29	safety	safety	NOUN
admet-184	9	30	aspects	aspect	NOUN
admet-184	9	31	.	.	PUNCT
admet-184	10	1	keywords	keyword	NOUN
admet-184	10	2	intranasal	intranasal	NOUN
admet-184	10	3	;	;	PUNCT
admet-184	10	4	insulin	insulin	NOUN
admet-184	10	5	;	;	PUNCT
admet-184	10	6	blood	blood	NOUN
admet-184	10	7	-	-	PUNCT
admet-184	10	8	brain	brain	NOUN
admet-184	10	9	-	-	PUNCT
admet-184	10	10	barrier	barrier	NOUN
admet-184	10	11	;	;	PUNCT
admet-184	10	12	medical	medical	ADJ
admet-184	10	13	device	device	NOUN
admet-184	10	14	;	;	PUNCT
admet-184	10	15	efficacy	efficacy	NOUN
admet-184	10	16	;	;	PUNCT
admet-184	10	17	cognition	cognition	NOUN
admet-184	10	18	;	;	PUNCT
admet-184	10	19	metabolism	metabolism	NOUN
admet-184	10	20	.	.	PUNCT
admet-184	11	1	cns	cns	PROPN
admet-184	11	2	delivery	delivery	NOUN
admet-184	11	3	–	–	PUNCT
admet-184	11	4	an	an	DET
admet-184	11	5	unmet	unmet	NOUN
admet-184	11	6	medical	medical	NOUN
admet-184	11	7	need	need	VERB
admet-184	11	8	the	the	DET
admet-184	11	9	world	world	NOUN
admet-184	11	10	health	health	NOUN
admet-184	11	11	organization	organization	NOUN
admet-184	11	12	(	(	PUNCT
admet-184	11	13	who	who	PRON
admet-184	11	14	)	)	PUNCT
admet-184	11	15	estimates	estimate	VERB
admet-184	11	16	that	that	SCONJ
admet-184	11	17	more	more	ADJ
admet-184	11	18	than	than	ADP
admet-184	11	19	a	a	DET
admet-184	11	20	billion	billion	NUM
admet-184	11	21	people	people	NOUN
admet-184	11	22	worldwide	worldwide	ADV
admet-184	11	23	are	be	AUX
admet-184	11	24	suffering	suffer	VERB
admet-184	11	25	from	from	ADP
admet-184	11	26	diseases	disease	NOUN
admet-184	11	27	of	of	ADP
admet-184	11	28	the	the	DET
admet-184	11	29	central	central	ADJ
admet-184	11	30	nervous	nervous	ADJ
admet-184	11	31	system	system	NOUN
admet-184	11	32	(	(	PUNCT
admet-184	11	33	cns	cns	NOUN
admet-184	11	34	;	;	PUNCT
admet-184	11	35	[	[	X
admet-184	11	36	1,2	1,2	NUM
admet-184	11	37	]	]	PUNCT
admet-184	11	38	)	)	PUNCT
admet-184	11	39	.	.	PUNCT
admet-184	12	1	alzheimer	alzheimer	PROPN
admet-184	12	2	’s	’s	PART
admet-184	12	3	disease	disease	NOUN
admet-184	12	4	(	(	PUNCT
admet-184	12	5	ad	ad	NOUN
admet-184	12	6	)	)	PUNCT
admet-184	12	7	is	be	AUX
admet-184	12	8	the	the	DET
admet-184	12	9	most	most	ADV
admet-184	12	10	common	common	ADJ
admet-184	12	11	neurodegenerative	neurodegenerative	ADJ
admet-184	12	12	dementia	dementia	NOUN
admet-184	12	13	in	in	ADP
admet-184	12	14	the	the	DET
admet-184	12	15	industrialized	industrialized	ADJ
admet-184	12	16	world	world	NOUN
admet-184	12	17	,	,	PUNCT
admet-184	12	18	with	with	ADP
admet-184	12	19	prevalence	prevalence	NOUN
admet-184	12	20	rates	rate	NOUN
admet-184	12	21	well	well	ADV
admet-184	12	22	over	over	ADP
admet-184	12	23	30	30	NUM
admet-184	12	24	%	%	NOUN
admet-184	12	25	in	in	ADP
admet-184	12	26	the	the	DET
admet-184	12	27	over	over	ADP
admet-184	12	28	80	80	NUM
admet-184	12	29	-	-	PUNCT
admet-184	12	30	years	year	NOUN
admet-184	12	31	-	-	PUNCT
admet-184	12	32	old	old	ADJ
admet-184	12	33	population	population	NOUN
admet-184	12	34	[	[	X
admet-184	12	35	1,2	1,2	NUM
admet-184	12	36	]	]	PUNCT
admet-184	12	37	.	.	PUNCT
admet-184	13	1	ad	ad	NOUN
admet-184	13	2	causes	cause	VERB
admet-184	13	3	enormous	enormous	ADJ
admet-184	13	4	costs	cost	NOUN
admet-184	13	5	to	to	ADP
admet-184	13	6	the	the	DET
admet-184	13	7	social	social	ADJ
admet-184	13	8	healthcare	healthcare	PROPN
admet-184	13	9	systems	system	NOUN
admet-184	13	10	,	,	PUNCT
admet-184	13	11	as	as	ADV
admet-184	13	12	well	well	ADV
admet-184	13	13	as	as	ADP
admet-184	13	14	personal	personal	ADJ
admet-184	13	15	tragedies	tragedy	NOUN
admet-184	13	16	for	for	ADP
admet-184	13	17	the	the	DET
admet-184	13	18	patients	patient	NOUN
admet-184	13	19	,	,	PUNCT
admet-184	13	20	families	family	NOUN
admet-184	13	21	and	and	CCONJ
admet-184	13	22	caregivers	caregiver	NOUN
admet-184	13	23	.	.	PUNCT
admet-184	14	1	like	like	ADP
admet-184	14	2	most	most	ADJ
admet-184	14	3	neurodegenerative	neurodegenerative	ADJ
admet-184	14	4	diseases	disease	NOUN
admet-184	14	5	,	,	PUNCT
admet-184	14	6	ad	ad	NOUN
admet-184	14	7	has	have	VERB
admet-184	14	8	a	a	DET
admet-184	14	9	poor	poor	ADJ
admet-184	14	10	prognosis	prognosis	NOUN
admet-184	14	11	and	and	CCONJ
admet-184	14	12	only	only	ADV
admet-184	14	13	symptomatic	symptomatic	ADJ
admet-184	14	14	therapy	therapy	NOUN
admet-184	14	15	is	be	AUX
admet-184	14	16	currently	currently	ADV
admet-184	14	17	available	available	ADJ
admet-184	14	18	.	.	PUNCT
admet-184	15	1	efficient	efficient	ADJ
admet-184	15	2	treatment	treatment	NOUN
admet-184	15	3	strategies	strategy	NOUN
admet-184	15	4	are	be	AUX
admet-184	15	5	still	still	ADV
admet-184	15	6	limited	limited	ADJ
admet-184	15	7	and	and	CCONJ
admet-184	15	8	an	an	DET
admet-184	15	9	aging	age	VERB
admet-184	15	10	society	society	NOUN
admet-184	15	11	in	in	ADP
admet-184	15	12	demographic	demographic	ADJ
admet-184	15	13	change	change	NOUN
admet-184	15	14	presents	present	VERB
admet-184	15	15	an	an	DET
admet-184	15	16	enormous	enormous	ADJ
admet-184	15	17	challenge	challenge	NOUN
admet-184	15	18	to	to	ADP
admet-184	15	19	the	the	DET
admet-184	15	20	health	health	NOUN
admet-184	15	21	systems	system	NOUN
admet-184	15	22	of	of	ADP
admet-184	15	23	industrialized	industrialized	ADJ
admet-184	15	24	nations	nation	NOUN
admet-184	15	25	.	.	PUNCT
admet-184	16	1	despite	despite	SCONJ
admet-184	16	2	the	the	DET
admet-184	16	3	extensive	extensive	ADJ
admet-184	16	4	research	research	NOUN
admet-184	16	5	and	and	CCONJ
admet-184	16	6	effort	effort	NOUN
admet-184	16	7	to	to	PART
admet-184	16	8	uncover	uncover	VERB
admet-184	16	9	the	the	DET
admet-184	16	10	mechanism	mechanism	NOUN
admet-184	16	11	of	of	ADP
admet-184	16	12	ad	ad	NOUN
admet-184	16	13	pathogenesis	pathogenesis	NOUN
admet-184	16	14	,	,	PUNCT
admet-184	16	15	more	more	ADJ
admet-184	16	16	or	or	CCONJ
admet-184	16	17	less	less	ADJ
admet-184	16	18	all	all	DET
admet-184	16	19	drug	drug	NOUN
admet-184	16	20	candidates	candidate	NOUN
admet-184	16	21	failed	fail	VERB
admet-184	16	22	to	to	PART
admet-184	16	23	demonstrate	demonstrate	VERB
admet-184	16	24	significant	significant	ADJ
admet-184	16	25	effects	effect	NOUN
admet-184	16	26	on	on	ADP
admet-184	16	27	cognition	cognition	NOUN
admet-184	16	28	in	in	ADP
admet-184	16	29	clinical	clinical	ADJ
admet-184	16	30	trials	trial	NOUN
admet-184	16	31	[	[	X
admet-184	16	32	3,4	3,4	NUM
admet-184	16	33	]	]	PUNCT
admet-184	16	34	.	.	PUNCT
admet-184	17	1	a	a	DET
admet-184	17	2	highly	highly	ADV
admet-184	17	3	critical	critical	ADJ
admet-184	17	4	point	point	NOUN
admet-184	17	5	in	in	ADP
admet-184	17	6	that	that	DET
admet-184	17	7	context	context	NOUN
admet-184	17	8	is	be	AUX
admet-184	17	9	the	the	DET
admet-184	17	10	low	low	ADJ
admet-184	17	11	central	central	ADJ
admet-184	17	12	availability	availability	NOUN
admet-184	17	13	of	of	ADP
admet-184	17	14	drugs	drug	NOUN
admet-184	17	15	.	.	PUNCT
admet-184	18	1	the	the	DET
admet-184	18	2	passage	passage	NOUN
admet-184	18	3	of	of	ADP
admet-184	18	4	most	most	ADJ
admet-184	18	5	cnsactive	cnsactive	ADJ
admet-184	18	6	drugs	drug	NOUN
admet-184	18	7	and	and	CCONJ
admet-184	18	8	in	in	ADP
admet-184	18	9	particular	particular	ADJ
admet-184	18	10	of	of	ADP
admet-184	18	11	biopharmaceuticals	biopharmaceutical	NOUN
admet-184	18	12	is	be	AUX
admet-184	18	13	massively	massively	ADV
admet-184	18	14	hampered	hamper	VERB
admet-184	18	15	by	by	ADP
admet-184	18	16	the	the	DET
admet-184	18	17	blood	blood	NOUN
admet-184	18	18	–	–	PUNCT
admet-184	18	19	brain	brain	NOUN
admet-184	18	20	barrier	barrier	NOUN
admet-184	18	21	mailto:zimmermann@hochschule-bc.de	mailto:zimmermann@hochschule-bc.de	CCONJ
admet-184	18	22	admet	admet	PROPN
admet-184	18	23	&	&	CCONJ
admet-184	18	24	dmpk	dmpk	PROPN
admet-184	18	25	3(3	3(3	NUM
admet-184	18	26	)	)	PUNCT
admet-184	18	27	(	(	PUNCT
admet-184	18	28	2015	2015	NUM
admet-184	18	29	)	)	PUNCT
admet-184	18	30	190	190	NUM
admet-184	18	31	-	-	SYM
admet-184	18	32	202	202	NUM
admet-184	18	33	intranasal	intranasal	ADJ
admet-184	18	34	insulin	insulin	NOUN
admet-184	18	35	as	as	ADP
admet-184	18	36	hope	hope	NOUN
admet-184	18	37	for	for	ADP
admet-184	18	38	ad	ad	NOUN
admet-184	18	39	?	?	PUNCT
admet-184	19	1	doi	doi	NOUN
admet-184	19	2	:	:	PUNCT
admet-184	19	3	10.5599	10.5599	NUM
admet-184	19	4	/	/	SYM
admet-184	19	5	admet.3.3.184	admet.3.3.184	NUM
admet-184	19	6	191	191	NUM
admet-184	19	7	(	(	PUNCT
admet-184	19	8	bbb	bbb	PROPN
admet-184	19	9	)	)	PUNCT
admet-184	19	10	.	.	PUNCT
admet-184	20	1	the	the	DET
admet-184	20	2	bbb	bbb	PROPN
admet-184	20	3	is	be	AUX
admet-184	20	4	located	locate	VERB
admet-184	20	5	at	at	ADP
admet-184	20	6	the	the	DET
admet-184	20	7	level	level	NOUN
admet-184	20	8	of	of	ADP
admet-184	20	9	the	the	DET
admet-184	20	10	cerebral	cerebral	ADJ
admet-184	20	11	microvasculature	microvasculature	NOUN
admet-184	20	12	and	and	CCONJ
admet-184	20	13	is	be	AUX
admet-184	20	14	important	important	ADJ
admet-184	20	15	for	for	ADP
admet-184	20	16	maintaining	maintain	VERB
admet-184	20	17	cns	cns	NOUN
admet-184	20	18	homeostasis	homeostasis	NOUN
admet-184	20	19	.	.	PUNCT
admet-184	21	1	though	though	ADV
admet-184	21	2	,	,	PUNCT
admet-184	21	3	the	the	DET
admet-184	21	4	bbb	bbb	NOUN
admet-184	21	5	restricts	restrict	VERB
admet-184	21	6	the	the	DET
admet-184	21	7	access	access	NOUN
admet-184	21	8	of	of	ADP
admet-184	21	9	potentially	potentially	ADV
admet-184	21	10	neurotoxic	neurotoxic	ADJ
admet-184	21	11	substances	substance	NOUN
admet-184	21	12	into	into	ADP
admet-184	21	13	the	the	DET
admet-184	21	14	brain	brain	NOUN
admet-184	21	15	,	,	PUNCT
admet-184	21	16	it	it	PRON
admet-184	21	17	impedes	impede	VERB
admet-184	21	18	massively	massively	ADV
admet-184	21	19	the	the	DET
admet-184	21	20	delivery	delivery	NOUN
admet-184	21	21	of	of	ADP
admet-184	21	22	therapeutic	therapeutic	ADJ
admet-184	21	23	drugs	drug	NOUN
admet-184	21	24	to	to	ADP
admet-184	21	25	the	the	DET
admet-184	21	26	cns	cns	PROPN
admet-184	21	27	.	.	PUNCT
admet-184	22	1	tight	tight	ADJ
admet-184	22	2	junctions	junction	NOUN
admet-184	22	3	between	between	ADP
admet-184	22	4	the	the	DET
admet-184	22	5	endothelial	endothelial	ADJ
admet-184	22	6	cells	cell	NOUN
admet-184	22	7	in	in	ADP
admet-184	22	8	the	the	DET
admet-184	22	9	cns	cns	NOUN
admet-184	22	10	block	block	NOUN
admet-184	22	11	the	the	DET
admet-184	22	12	natural	natural	ADJ
admet-184	22	13	transport	transport	NOUN
admet-184	22	14	and	and	CCONJ
admet-184	22	15	hence	hence	ADV
admet-184	22	16	seal	seal	VERB
admet-184	22	17	the	the	DET
admet-184	22	18	blood	blood	NOUN
admet-184	22	19	compartment	compartment	NOUN
admet-184	22	20	from	from	ADP
admet-184	22	21	the	the	DET
admet-184	22	22	brain	brain	NOUN
admet-184	22	23	compartment	compartment	NOUN
admet-184	22	24	[	[	X
admet-184	22	25	5	5	NUM
admet-184	22	26	]	]	PUNCT
admet-184	22	27	.	.	PUNCT
admet-184	23	1	a	a	DET
admet-184	23	2	limited	limited	ADJ
admet-184	23	3	number	number	NOUN
admet-184	23	4	of	of	ADP
admet-184	23	5	essential	essential	ADJ
admet-184	23	6	nutrients	nutrient	NOUN
admet-184	23	7	like	like	ADP
admet-184	23	8	glucose	glucose	NOUN
admet-184	23	9	and	and	CCONJ
admet-184	23	10	amino	amino	NOUN
admet-184	23	11	acids	acid	NOUN
admet-184	23	12	,	,	PUNCT
admet-184	23	13	co	co	NOUN
admet-184	23	14	-	-	NOUN
admet-184	23	15	factors	factor	NOUN
admet-184	23	16	like	like	ADP
admet-184	23	17	iron	iron	NOUN
admet-184	23	18	,	,	PUNCT
admet-184	23	19	and	and	CCONJ
admet-184	23	20	peptide	peptide	ADJ
admet-184	23	21	hormones	hormone	NOUN
admet-184	23	22	like	like	ADP
admet-184	23	23	insulin	insulin	NOUN
admet-184	23	24	are	be	AUX
admet-184	23	25	actively	actively	ADV
admet-184	23	26	transported	transport	VERB
admet-184	23	27	across	across	ADP
admet-184	23	28	the	the	DET
admet-184	23	29	bbb	bbb	NOUN
admet-184	24	1	[	[	X
admet-184	24	2	6	6	NUM
admet-184	24	3	-	-	SYM
admet-184	24	4	9	9	NUM
admet-184	24	5	]	]	PUNCT
admet-184	24	6	.	.	PUNCT
admet-184	25	1	molecules	molecule	NOUN
admet-184	25	2	that	that	PRON
admet-184	25	3	do	do	AUX
admet-184	25	4	not	not	PART
admet-184	25	5	possess	possess	VERB
admet-184	25	6	a	a	DET
admet-184	25	7	specific	specific	ADJ
admet-184	25	8	transport	transport	NOUN
admet-184	25	9	mechanism	mechanism	NOUN
admet-184	25	10	have	have	VERB
admet-184	25	11	only	only	ADV
admet-184	25	12	a	a	DET
admet-184	25	13	chance	chance	NOUN
admet-184	25	14	to	to	PART
admet-184	25	15	pass	pass	VERB
admet-184	25	16	the	the	DET
admet-184	25	17	bbb	bbb	NOUN
admet-184	25	18	via	via	ADP
admet-184	25	19	passive	passive	ADJ
admet-184	25	20	diffusion	diffusion	NOUN
admet-184	25	21	.	.	PUNCT
admet-184	26	1	while	while	SCONJ
admet-184	26	2	there	there	PRON
admet-184	26	3	are	be	VERB
admet-184	26	4	at	at	ADP
admet-184	26	5	least	least	ADJ
admet-184	26	6	some	some	DET
admet-184	26	7	good	good	ADJ
admet-184	26	8	examples	example	NOUN
admet-184	26	9	of	of	ADP
admet-184	26	10	chemical	chemical	ADJ
admet-184	26	11	modifications	modification	NOUN
admet-184	26	12	for	for	ADP
admet-184	26	13	small	small	ADJ
admet-184	26	14	molecule	molecule	NOUN
admet-184	26	15	drugs	drug	NOUN
admet-184	26	16	to	to	PART
admet-184	26	17	enhance	enhance	VERB
admet-184	26	18	their	their	PRON
admet-184	26	19	central	central	ADJ
admet-184	26	20	bioavailability	bioavailability	NOUN
admet-184	26	21	,	,	PUNCT
admet-184	26	22	nearly	nearly	ADV
admet-184	26	23	all	all	PRON
admet-184	26	24	of	of	ADP
admet-184	26	25	the	the	DET
admet-184	26	26	larger	large	ADJ
admet-184	26	27	molecules	molecule	NOUN
admet-184	26	28	such	such	ADJ
admet-184	26	29	as	as	ADP
admet-184	26	30	peptides	peptide	NOUN
admet-184	26	31	and	and	CCONJ
admet-184	26	32	proteins	protein	NOUN
admet-184	26	33	fail	fail	VERB
admet-184	26	34	to	to	PART
admet-184	26	35	cross	cross	VERB
admet-184	26	36	the	the	DET
admet-184	26	37	bbb	bbb	NOUN
admet-184	27	1	[	[	X
admet-184	27	2	10	10	NUM
admet-184	27	3	]	]	PUNCT
admet-184	27	4	.	.	PUNCT
admet-184	28	1	currently	currently	ADV
admet-184	28	2	,	,	PUNCT
admet-184	28	3	all	all	DET
admet-184	28	4	biopharmaceuticals	biopharmaceutical	NOUN
admet-184	28	5	that	that	PRON
admet-184	28	6	are	be	AUX
admet-184	28	7	used	use	VERB
admet-184	28	8	or	or	CCONJ
admet-184	28	9	being	be	AUX
admet-184	28	10	evaluated	evaluate	VERB
admet-184	28	11	in	in	ADP
admet-184	28	12	the	the	DET
admet-184	28	13	clinics	clinic	NOUN
admet-184	28	14	for	for	ADP
admet-184	28	15	cns	cns	PROPN
admet-184	28	16	disease	disease	NOUN
admet-184	28	17	act	act	VERB
admet-184	28	18	predominantly	predominantly	ADV
admet-184	28	19	via	via	ADP
admet-184	28	20	peripheral	peripheral	ADJ
admet-184	28	21	mechanism	mechanism	NOUN
admet-184	28	22	:	:	PUNCT
admet-184	28	23	e.g.	e.g.	ADV
admet-184	28	24	anti	anti	ADJ
admet-184	28	25	-	-	ADJ
admet-184	28	26	amyloid-	amyloid-	ADJ
admet-184	28	27	(	(	PUNCT
admet-184	28	28	a	a	NOUN
admet-184	28	29	)	)	PUNCT
admet-184	28	30	capturing	capture	VERB
admet-184	28	31	monoclonal	monoclonal	NOUN
admet-184	28	32	/	/	SYM
admet-184	28	33	polyclonal	polyclonal	ADJ
admet-184	28	34	antibodies	antibody	NOUN
admet-184	28	35	in	in	ADP
admet-184	28	36	ad	ad	NOUN
admet-184	28	37	[	[	X
admet-184	28	38	3,4	3,4	NUM
admet-184	28	39	]	]	PUNCT
admet-184	28	40	or	or	CCONJ
admet-184	28	41	immune	immune	ADJ
admet-184	28	42	cell	cell	NOUN
admet-184	28	43	regulating	regulate	VERB
admet-184	28	44	biopharmaceuticals	biopharmaceutical	NOUN
admet-184	28	45	in	in	ADP
admet-184	28	46	multiple	multiple	ADJ
admet-184	28	47	sclerosis	sclerosis	NOUN
admet-184	28	48	[	[	X
admet-184	28	49	11	11	NUM
admet-184	28	50	]	]	PUNCT
admet-184	28	51	.	.	PUNCT
admet-184	29	1	however	however	ADV
admet-184	29	2	,	,	PUNCT
admet-184	29	3	candidate	candidate	NOUN
admet-184	29	4	biopharmaceuticals	biopharmaceutical	NOUN
admet-184	29	5	reveal	reveal	VERB
admet-184	29	6	promising	promising	ADJ
admet-184	29	7	results	result	NOUN
admet-184	29	8	in	in	ADP
admet-184	29	9	cellular	cellular	ADJ
admet-184	29	10	models	model	NOUN
admet-184	29	11	or	or	CCONJ
admet-184	29	12	in	in	ADP
admet-184	29	13	animal	animal	NOUN
admet-184	29	14	models	model	NOUN
admet-184	29	15	when	when	SCONJ
admet-184	29	16	delivered	deliver	VERB
admet-184	29	17	intracerebroventricular	intracerebroventricular	ADJ
admet-184	29	18	.	.	PUNCT
admet-184	30	1	the	the	DET
admet-184	30	2	current	current	ADJ
admet-184	30	3	state	state	NOUN
admet-184	30	4	-	-	PUNCT
admet-184	30	5	of	of	ADP
admet-184	30	6	-	-	PUNCT
admet-184	30	7	the	the	DET
admet-184	30	8	-	-	PUNCT
admet-184	30	9	art	art	NOUN
admet-184	30	10	to	to	PART
admet-184	30	11	deliver	deliver	VERB
admet-184	30	12	drugs	drug	NOUN
admet-184	30	13	with	with	ADP
admet-184	30	14	a	a	DET
admet-184	30	15	low	low	ADJ
admet-184	30	16	central	central	ADJ
admet-184	30	17	bioavailability	bioavailability	NOUN
admet-184	30	18	is	be	AUX
admet-184	30	19	intrathecal	intrathecal	ADJ
admet-184	30	20	,	,	PUNCT
admet-184	30	21	intracerebroventricular	intracerebroventricular	ADJ
admet-184	30	22	or	or	CCONJ
admet-184	30	23	intraparenchymal	intraparenchymal	ADJ
admet-184	30	24	injections	injection	NOUN
admet-184	30	25	that	that	PRON
admet-184	30	26	deliver	deliver	VERB
admet-184	30	27	directly	directly	ADV
admet-184	30	28	to	to	ADP
admet-184	30	29	the	the	DET
admet-184	30	30	cerebrospinal	cerebrospinal	ADJ
admet-184	30	31	fluid	fluid	NOUN
admet-184	30	32	(	(	PUNCT
admet-184	30	33	csf	csf	NOUN
admet-184	30	34	)	)	PUNCT
admet-184	30	35	of	of	ADP
admet-184	30	36	the	the	DET
admet-184	30	37	cns	cns	NOUN
admet-184	30	38	,	,	PUNCT
admet-184	30	39	some	some	PRON
admet-184	30	40	of	of	ADP
admet-184	30	41	them	they	PRON
admet-184	30	42	are	be	AUX
admet-184	30	43	given	give	VERB
admet-184	30	44	chronically	chronically	ADV
admet-184	30	45	via	via	ADP
admet-184	30	46	an	an	DET
admet-184	30	47	implanted	implant	VERB
admet-184	30	48	intrathecal	intrathecal	ADJ
admet-184	30	49	micropump	micropump	NOUN
admet-184	30	50	(	(	PUNCT
admet-184	30	51	e.	e.	PROPN
admet-184	30	52	g.	g.	PROPN
admet-184	30	53	synchromed	synchromed	PROPN
admet-184	30	54	®	®	PROPN
admet-184	30	55	;	;	PUNCT
admet-184	30	56	[	[	X
admet-184	30	57	12,13	12,13	NUM
admet-184	30	58	]	]	PUNCT
admet-184	30	59	)	)	PUNCT
admet-184	30	60	.	.	PUNCT
admet-184	31	1	although	although	SCONJ
admet-184	31	2	,	,	PUNCT
admet-184	31	3	such	such	ADJ
admet-184	31	4	delivery	delivery	NOUN
admet-184	31	5	systems	system	NOUN
admet-184	31	6	are	be	AUX
admet-184	31	7	commonly	commonly	ADV
admet-184	31	8	used	use	VERB
admet-184	31	9	for	for	ADP
admet-184	31	10	baclofen	baclofen	NOUN
admet-184	31	11	for	for	ADP
admet-184	31	12	the	the	DET
admet-184	31	13	treatment	treatment	NOUN
admet-184	31	14	of	of	ADP
admet-184	31	15	spasticity	spasticity	NOUN
admet-184	31	16	or	or	CCONJ
admet-184	31	17	analgetics	analgetic	NOUN
admet-184	31	18	for	for	ADP
admet-184	31	19	the	the	DET
admet-184	31	20	treatment	treatment	NOUN
admet-184	31	21	of	of	ADP
admet-184	31	22	cancer	cancer	NOUN
admet-184	31	23	pain	pain	NOUN
admet-184	31	24	[	[	X
admet-184	31	25	14	14	NUM
admet-184	31	26	]	]	PUNCT
admet-184	31	27	,	,	PUNCT
admet-184	31	28	these	these	DET
admet-184	31	29	routes	route	NOUN
admet-184	31	30	of	of	ADP
admet-184	31	31	administration	administration	NOUN
admet-184	31	32	are	be	AUX
admet-184	31	33	invasive	invasive	ADJ
admet-184	31	34	and	and	CCONJ
admet-184	31	35	provide	provide	VERB
admet-184	31	36	a	a	DET
admet-184	31	37	long	long	ADJ
admet-184	31	38	list	list	NOUN
admet-184	31	39	of	of	ADP
admet-184	31	40	adverse	adverse	ADJ
admet-184	31	41	events	event	NOUN
admet-184	31	42	and	and	CCONJ
admet-184	31	43	contraindications	contraindication	NOUN
admet-184	31	44	[	[	X
admet-184	31	45	15,16	15,16	NUM
admet-184	31	46	]	]	PUNCT
admet-184	31	47	.	.	PUNCT
admet-184	32	1	hence	hence	ADV
admet-184	32	2	,	,	PUNCT
admet-184	32	3	a	a	DET
admet-184	32	4	safe	safe	ADJ
admet-184	32	5	and	and	CCONJ
admet-184	32	6	efficient	efficient	ADJ
admet-184	32	7	drug	drug	NOUN
admet-184	32	8	delivery	delivery	NOUN
admet-184	32	9	platform	platform	NOUN
admet-184	32	10	technology	technology	NOUN
admet-184	32	11	for	for	ADP
admet-184	32	12	cns	cns	NOUN
admet-184	32	13	active	active	ADJ
admet-184	32	14	molecules	molecule	NOUN
admet-184	32	15	is	be	AUX
admet-184	32	16	needed	need	VERB
admet-184	32	17	[	[	X
admet-184	32	18	17	17	NUM
admet-184	32	19	]	]	PUNCT
admet-184	32	20	.	.	PUNCT
admet-184	33	1	nose	nose	NOUN
admet-184	33	2	to	to	ADP
admet-184	33	3	brain	brain	NOUN
admet-184	33	4	(	(	PUNCT
admet-184	33	5	n2b	n2b	NOUN
admet-184	33	6	)	)	PUNCT
admet-184	33	7	intranasal	intranasal	ADJ
admet-184	33	8	delivery	delivery	NOUN
admet-184	33	9	intranasal	intranasal	NOUN
admet-184	33	10	nose	nose	NOUN
admet-184	33	11	to	to	ADP
admet-184	33	12	brain	brain	NOUN
admet-184	33	13	(	(	PUNCT
admet-184	33	14	n2b	n2b	NOUN
admet-184	33	15	)	)	PUNCT
admet-184	33	16	delivery	delivery	NOUN
admet-184	33	17	to	to	ADP
admet-184	33	18	the	the	DET
admet-184	33	19	upper	upper	ADJ
admet-184	33	20	third	third	NOUN
admet-184	33	21	of	of	ADP
admet-184	33	22	the	the	DET
admet-184	33	23	nasal	nasal	ADJ
admet-184	33	24	cavity	cavity	NOUN
admet-184	33	25	bypasses	bypass	VERB
admet-184	33	26	the	the	DET
admet-184	33	27	blood	blood	NOUN
admet-184	33	28	-	-	PUNCT
admet-184	33	29	brain	brain	NOUN
admet-184	33	30	barrier	barrier	NOUN
admet-184	33	31	to	to	PART
admet-184	33	32	rapidly	rapidly	ADV
admet-184	33	33	target	target	VERB
admet-184	33	34	therapeutics	therapeutic	NOUN
admet-184	33	35	to	to	ADP
admet-184	33	36	the	the	DET
admet-184	33	37	cns	cns	NOUN
admet-184	33	38	along	along	ADP
admet-184	33	39	the	the	DET
admet-184	33	40	olfactory	olfactory	NOUN
admet-184	33	41	and	and	CCONJ
admet-184	33	42	trigeminal	trigeminal	ADJ
admet-184	33	43	neural	neural	ADJ
admet-184	33	44	pathways	pathway	NOUN
admet-184	33	45	(	(	PUNCT
admet-184	33	46	for	for	ADP
admet-184	33	47	excellent	excellent	ADJ
admet-184	33	48	summary	summary	NOUN
admet-184	33	49	see	see	VERB
admet-184	33	50	[	[	X
admet-184	33	51	18	18	NUM
admet-184	33	52	]	]	NUM
admet-184	33	53	)	)	PUNCT
admet-184	33	54	.	.	PUNCT
admet-184	34	1	the	the	DET
admet-184	34	2	n2b	n2b	PROPN
admet-184	34	3	route	route	NOUN
admet-184	34	4	of	of	ADP
admet-184	34	5	administration	administration	NOUN
admet-184	34	6	provides	provide	VERB
admet-184	34	7	a	a	DET
admet-184	34	8	nonto	nonto	NOUN
admet-184	34	9	minimal	minimal	ADJ
admet-184	34	10	-	-	PUNCT
admet-184	34	11	invasive	invasive	ADJ
admet-184	34	12	method	method	NOUN
admet-184	34	13	of	of	ADP
admet-184	34	14	bypassing	bypass	VERB
admet-184	34	15	the	the	DET
admet-184	34	16	bbb	bbb	PROPN
admet-184	34	17	.	.	PUNCT
admet-184	35	1	anatomy	anatomy	NOUN
admet-184	35	2	and	and	CCONJ
admet-184	35	3	histology	histology	NOUN
admet-184	35	4	of	of	ADP
admet-184	35	5	the	the	DET
admet-184	35	6	nasal	nasal	ADJ
admet-184	35	7	cavity	cavity	NOUN
admet-184	35	8	the	the	DET
admet-184	35	9	nasal	nasal	ADJ
admet-184	35	10	cavity	cavity	NOUN
admet-184	35	11	is	be	AUX
admet-184	35	12	divided	divide	VERB
admet-184	35	13	longitudinally	longitudinally	ADV
admet-184	35	14	by	by	ADP
admet-184	35	15	the	the	DET
admet-184	35	16	nasal	nasal	PROPN
admet-184	35	17	septum	septum	PROPN
admet-184	35	18	and	and	CCONJ
admet-184	35	19	extends	extend	VERB
admet-184	35	20	from	from	ADP
admet-184	35	21	the	the	DET
admet-184	35	22	nostrils	nostril	NOUN
admet-184	35	23	to	to	ADP
admet-184	35	24	the	the	DET
admet-184	35	25	nasopharynx	nasopharynx	NOUN
admet-184	35	26	(	(	PUNCT
admet-184	35	27	roughly	roughly	ADV
admet-184	35	28	12–14	12–14	NUM
admet-184	35	29	cm	cm	NOUN
admet-184	35	30	)	)	PUNCT
admet-184	35	31	,	,	PUNCT
admet-184	35	32	but	but	CCONJ
admet-184	35	33	has	have	VERB
admet-184	35	34	an	an	DET
admet-184	35	35	impressively	impressively	ADV
admet-184	35	36	large	large	ADJ
admet-184	35	37	mucosa	mucosa	NOUN
admet-184	35	38	surface	surface	NOUN
admet-184	35	39	area	area	NOUN
admet-184	35	40	(	(	PUNCT
admet-184	35	41	about	about	ADV
admet-184	35	42	160	160	NUM
admet-184	35	43	cm2	cm2	NOUN
admet-184	35	44	)	)	PUNCT
admet-184	36	1	[	[	X
admet-184	36	2	18,19	18,19	NUM
admet-184	36	3	]	]	PUNCT
admet-184	36	4	.	.	PUNCT
admet-184	37	1	the	the	DET
admet-184	37	2	frontal	frontal	ADJ
admet-184	37	3	and	and	CCONJ
admet-184	37	4	lateral	lateral	ADJ
admet-184	37	5	views	view	NOUN
admet-184	37	6	are	be	AUX
admet-184	37	7	shown	show	VERB
admet-184	37	8	in	in	ADP
admet-184	37	9	figure	figure	NOUN
admet-184	37	10	1	1	NUM
admet-184	37	11	.	.	PUNCT
admet-184	37	12	three	three	NUM
admet-184	37	13	turbinates	turbinate	NOUN
admet-184	37	14	(	(	PUNCT
admet-184	37	15	also	also	ADV
admet-184	37	16	called	call	VERB
admet-184	37	17	conchae	concha	NOUN
admet-184	37	18	)	)	PUNCT
admet-184	37	19	are	be	AUX
admet-184	37	20	the	the	DET
admet-184	37	21	cause	cause	NOUN
admet-184	37	22	for	for	ADP
admet-184	37	23	the	the	DET
admet-184	37	24	large	large	ADJ
admet-184	37	25	surface	surface	NOUN
admet-184	37	26	area	area	NOUN
admet-184	37	27	and	and	CCONJ
admet-184	37	28	their	their	PRON
admet-184	37	29	biological	biological	ADJ
admet-184	37	30	function	function	NOUN
admet-184	37	31	is	be	AUX
admet-184	37	32	to	to	PART
admet-184	37	33	humidify	humidify	VERB
admet-184	37	34	,	,	PUNCT
admet-184	37	35	warm	warm	ADJ
admet-184	37	36	and	and	CCONJ
admet-184	37	37	filter	filter	VERB
admet-184	37	38	the	the	DET
admet-184	37	39	inspired	inspired	ADJ
admet-184	37	40	air	air	NOUN
admet-184	37	41	.	.	PUNCT
admet-184	38	1	nasal	nasal	ADJ
admet-184	38	2	secretions	secretion	NOUN
admet-184	38	3	and	and	CCONJ
admet-184	38	4	inhaled	inhaled	ADJ
admet-184	38	5	particles	particle	NOUN
admet-184	38	6	are	be	AUX
admet-184	38	7	transported	transport	VERB
admet-184	38	8	to	to	ADP
admet-184	38	9	the	the	DET
admet-184	38	10	nasopharynx	nasopharynx	NOUN
admet-184	38	11	via	via	ADP
admet-184	38	12	mucociliar	mucociliar	ADJ
admet-184	38	13	clearance	clearance	NOUN
admet-184	38	14	,	,	PUNCT
admet-184	38	15	where	where	SCONJ
admet-184	38	16	they	they	PRON
admet-184	38	17	are	be	AUX
admet-184	38	18	swallowed	swallow	VERB
admet-184	38	19	or	or	CCONJ
admet-184	38	20	expectorated	expectorate	VERB
admet-184	38	21	.	.	PUNCT
admet-184	39	1	importantly	importantly	ADV
admet-184	39	2	,	,	PUNCT
admet-184	39	3	the	the	DET
admet-184	39	4	nasal	nasal	ADJ
admet-184	39	5	mucosa	mucosa	PROPN
admet-184	39	6	provides	provide	VERB
admet-184	39	7	very	very	ADV
admet-184	39	8	important	important	ADJ
admet-184	39	9	immune	immune	ADJ
admet-184	39	10	function	function	NOUN
admet-184	39	11	since	since	SCONJ
admet-184	39	12	countless	countless	ADJ
admet-184	39	13	inhaled	inhale	VERB
admet-184	39	14	pathogens	pathogen	NOUN
admet-184	39	15	are	be	AUX
admet-184	39	16	filtered	filter	VERB
admet-184	39	17	here	here	ADV
admet-184	39	18	and	and	CCONJ
admet-184	39	19	transported	transport	VERB
admet-184	39	20	to	to	ADP
admet-184	39	21	the	the	DET
admet-184	39	22	nasopharynxassociated	nasopharynxassociate	VERB
admet-184	39	23	lymphoid	lymphoid	ADJ
admet-184	39	24	tissue	tissue	NOUN
admet-184	40	1	[	[	X
admet-184	40	2	20	20	NUM
admet-184	40	3	]	]	PUNCT
admet-184	40	4	.	.	PUNCT
admet-184	41	1	therefore	therefore	ADV
admet-184	41	2	,	,	PUNCT
admet-184	41	3	intranasal	intranasal	ADJ
admet-184	41	4	vaccinations	vaccination	NOUN
admet-184	41	5	like	like	ADP
admet-184	41	6	flumist	flumist	ADJ
admet-184	41	7	®	®	NOUN
admet-184	41	8	replace	replace	VERB
admet-184	41	9	more	more	ADJ
admet-184	41	10	and	and	CCONJ
admet-184	41	11	more	more	ADJ
admet-184	41	12	injection	injection	NOUN
admet-184	41	13	-	-	PUNCT
admet-184	41	14	associated	associate	VERB
admet-184	41	15	vaccinations	vaccination	NOUN
admet-184	41	16	.	.	PUNCT
admet-184	42	1	the	the	DET
admet-184	42	2	nasal	nasal	PROPN
admet-184	42	3	mucosa	mucosa	PROPN
admet-184	42	4	consists	consist	VERB
admet-184	42	5	of	of	ADP
admet-184	42	6	four	four	NUM
admet-184	42	7	different	different	ADJ
admet-184	42	8	epithelia	epithelium	NOUN
admet-184	42	9	:	:	PUNCT
admet-184	42	10	respiratory	respiratory	ADJ
admet-184	42	11	,	,	PUNCT
admet-184	42	12	olfactory	olfactory	ADJ
admet-184	42	13	,	,	PUNCT
admet-184	42	14	squamous	squamous	ADJ
admet-184	42	15	and	and	CCONJ
admet-184	42	16	transitional	transitional	ADJ
admet-184	42	17	epithelium	epithelium	NOUN
admet-184	42	18	[	[	X
admet-184	42	19	21	21	NUM
admet-184	42	20	]	]	PUNCT
admet-184	42	21	.	.	PUNCT
admet-184	43	1	the	the	DET
admet-184	43	2	squamous	squamous	ADJ
admet-184	43	3	epithelium	epithelium	NOUN
admet-184	43	4	covers	cover	VERB
admet-184	43	5	the	the	DET
admet-184	43	6	nasal	nasal	PROPN
admet-184	43	7	vestibule	vestibule	NOUN
admet-184	43	8	from	from	ADP
admet-184	43	9	the	the	DET
admet-184	43	10	nostrils	nostril	NOUN
admet-184	43	11	to	to	ADP
admet-184	43	12	the	the	DET
admet-184	43	13	anterior	anterior	ADJ
admet-184	43	14	part	part	NOUN
admet-184	43	15	of	of	ADP
admet-184	43	16	the	the	DET
admet-184	43	17	turbinates	turbinate	NOUN
admet-184	43	18	and	and	CCONJ
admet-184	43	19	harbours	harbour	VERB
admet-184	43	20	hairs	hair	NOUN
admet-184	43	21	and	and	CCONJ
admet-184	43	22	glands	gland	NOUN
admet-184	43	23	.	.	PUNCT
admet-184	44	1	the	the	DET
admet-184	44	2	transitional	transitional	ADJ
admet-184	44	3	epithelium	epithelium	NOUN
admet-184	44	4	is	be	AUX
admet-184	44	5	located	locate	VERB
admet-184	44	6	at	at	ADP
admet-184	44	7	the	the	DET
admet-184	44	8	transitions	transition	NOUN
admet-184	44	9	between	between	ADP
admet-184	44	10	the	the	DET
admet-184	44	11	other	other	ADJ
admet-184	44	12	three	three	NUM
admet-184	44	13	types	type	NOUN
admet-184	44	14	of	of	ADP
admet-184	44	15	epithelium	epithelium	NOUN
admet-184	44	16	and	and	CCONJ
admet-184	44	17	appears	appear	VERB
admet-184	44	18	not	not	PART
admet-184	44	19	to	to	PART
admet-184	44	20	have	have	VERB
admet-184	44	21	a	a	DET
admet-184	44	22	relevant	relevant	ADJ
admet-184	44	23	role	role	NOUN
admet-184	44	24	in	in	ADP
admet-184	44	25	intranasal	intranasal	ADJ
admet-184	44	26	delivery	delivery	NOUN
admet-184	44	27	.	.	PUNCT
admet-184	45	1	the	the	DET
admet-184	45	2	nasal	nasal	ADJ
admet-184	45	3	respiratory	respiratory	ADJ
admet-184	45	4	epithelium	epithelium	NOUN
admet-184	45	5	is	be	AUX
admet-184	45	6	a	a	DET
admet-184	45	7	pseudostratified	pseudostratifie	VERB
admet-184	45	8	columnar	columnar	ADJ
admet-184	45	9	secretory	secretory	NOUN
admet-184	45	10	epithelium	epithelium	NOUN
admet-184	45	11	that	that	PRON
admet-184	45	12	is	be	AUX
admet-184	45	13	formed	form	VERB
admet-184	45	14	by	by	ADP
admet-184	45	15	ciliated	ciliated	ADJ
admet-184	45	16	cells	cell	NOUN
admet-184	45	17	,	,	PUNCT
admet-184	45	18	goblet	goblet	NOUN
admet-184	45	19	cells	cell	NOUN
admet-184	45	20	,	,	PUNCT
admet-184	45	21	intermediate	intermediate	ADJ
admet-184	45	22	cells	cell	NOUN
admet-184	45	23	and	and	CCONJ
admet-184	45	24	basal	basal	ADJ
admet-184	45	25	cells	cell	NOUN
admet-184	45	26	.	.	PUNCT
admet-184	46	1	the	the	DET
admet-184	46	2	tissue	tissue	NOUN
admet-184	46	3	shares	share	VERB
admet-184	46	4	high	high	ADJ
admet-184	46	5	similarity	similarity	NOUN
admet-184	46	6	to	to	ADP
admet-184	46	7	the	the	DET
admet-184	46	8	m.	m.	NOUN
admet-184	46	9	stützle	stützle	NOUN
admet-184	46	10	,	,	PUNCT
admet-184	46	11	j.	j.	PROPN
admet-184	46	12	flamm	flamm	PROPN
admet-184	46	13	,	,	PUNCT
admet-184	46	14	s.	s.	PROPN
admet-184	46	15	carle	carle	PROPN
admet-184	46	16	and	and	CCONJ
admet-184	46	17	k.	k.	PROPN
admet-184	46	18	schindowski	schindowski	PROPN
admet-184	46	19	admet	admet	PROPN
admet-184	46	20	&	&	CCONJ
admet-184	46	21	dmpk	dmpk	PROPN
admet-184	46	22	3(3	3(3	NUM
admet-184	46	23	)	)	PUNCT
admet-184	46	24	(	(	PUNCT
admet-184	46	25	2015	2015	NUM
admet-184	46	26	)	)	PUNCT
admet-184	46	27	190	190	NUM
admet-184	46	28	-	-	SYM
admet-184	46	29	202	202	NUM
admet-184	46	30	192	192	NUM
admet-184	46	31	respiratory	respiratory	ADJ
admet-184	46	32	epithelium	epithelium	NOUN
admet-184	46	33	of	of	ADP
admet-184	46	34	the	the	DET
admet-184	46	35	lung	lung	NOUN
admet-184	46	36	and	and	CCONJ
admet-184	46	37	covers	cover	VERB
admet-184	46	38	up	up	ADP
admet-184	46	39	to	to	PART
admet-184	46	40	90	90	NUM
admet-184	46	41	%	%	NOUN
admet-184	46	42	of	of	ADP
admet-184	46	43	the	the	DET
admet-184	46	44	nasal	nasal	ADJ
admet-184	46	45	cavity	cavity	NOUN
admet-184	46	46	in	in	ADP
admet-184	46	47	humans	human	NOUN
admet-184	46	48	and	and	CCONJ
admet-184	46	49	roughly	roughly	ADV
admet-184	46	50	50	50	NUM
admet-184	46	51	%	%	NOUN
admet-184	46	52	in	in	ADP
admet-184	46	53	rodents	rodent	NOUN
admet-184	46	54	[	[	X
admet-184	46	55	18	18	NUM
admet-184	46	56	]	]	PUNCT
admet-184	46	57	.	.	PUNCT
admet-184	47	1	through	through	ADP
admet-184	47	2	close	close	ADJ
admet-184	47	3	contact	contact	NOUN
admet-184	47	4	with	with	ADP
admet-184	47	5	inspired	inspire	VERB
admet-184	47	6	air	air	NOUN
admet-184	47	7	,	,	PUNCT
admet-184	47	8	it	it	PRON
admet-184	47	9	warms	warm	VERB
admet-184	47	10	and	and	CCONJ
admet-184	47	11	humidifies	humidify	VERB
admet-184	47	12	the	the	DET
admet-184	47	13	air	air	NOUN
admet-184	47	14	and	and	CCONJ
admet-184	47	15	air	air	NOUN
admet-184	47	16	-	-	PUNCT
admet-184	47	17	borne	bear	VERB
admet-184	47	18	particles	particle	NOUN
admet-184	47	19	and	and	CCONJ
admet-184	47	20	pathogens	pathogen	NOUN
admet-184	47	21	are	be	AUX
admet-184	47	22	removed	remove	VERB
admet-184	47	23	.	.	PUNCT
admet-184	48	1	different	different	ADJ
admet-184	48	2	serous	serous	ADJ
admet-184	48	3	glands	gland	NOUN
admet-184	48	4	produce	produce	VERB
admet-184	48	5	the	the	DET
admet-184	48	6	nasal	nasal	ADJ
admet-184	48	7	mucus	mucus	NOUN
admet-184	48	8	and	and	CCONJ
admet-184	48	9	nasal	nasal	ADJ
admet-184	48	10	secretion	secretion	NOUN
admet-184	48	11	that	that	PRON
admet-184	48	12	are	be	AUX
admet-184	48	13	propelled	propel	VERB
admet-184	48	14	from	from	ADP
admet-184	48	15	the	the	DET
admet-184	48	16	ciliated	ciliated	ADJ
admet-184	48	17	cells	cell	NOUN
admet-184	48	18	to	to	ADP
admet-184	48	19	the	the	DET
admet-184	48	20	nasopharynx	nasopharynx	NOUN
admet-184	48	21	.	.	PUNCT
admet-184	49	1	the	the	DET
admet-184	49	2	mucus	mucus	NOUN
admet-184	49	3	is	be	AUX
admet-184	49	4	well	well	ADV
admet-184	49	5	characterized	characterize	VERB
admet-184	49	6	and	and	CCONJ
admet-184	49	7	creates	create	VERB
admet-184	49	8	a	a	DET
admet-184	49	9	mild	mild	ADJ
admet-184	49	10	acidic	acidic	ADJ
admet-184	49	11	and	and	CCONJ
admet-184	49	12	antibacterial	antibacterial	ADJ
admet-184	49	13	milieu	milieu	NOUN
admet-184	49	14	with	with	ADP
admet-184	49	15	a	a	DET
admet-184	49	16	ph	ph	NOUN
admet-184	49	17	of	of	ADP
admet-184	49	18	5.5	5.5	NUM
admet-184	49	19	6.5	6.5	NUM
admet-184	49	20	[	[	SYM
admet-184	49	21	19	19	NUM
admet-184	49	22	]	]	PUNCT
admet-184	49	23	.	.	PUNCT
admet-184	50	1	the	the	DET
admet-184	50	2	nasal	nasal	ADJ
admet-184	50	3	respiratory	respiratory	ADJ
admet-184	50	4	epithelium	epithelium	NOUN
admet-184	50	5	is	be	AUX
admet-184	50	6	innervated	innervate	VERB
admet-184	50	7	by	by	ADP
admet-184	50	8	the	the	DET
admet-184	50	9	trigeminal	trigeminal	ADJ
admet-184	50	10	nerve	nerve	NOUN
admet-184	50	11	,	,	PUNCT
admet-184	50	12	the	the	DET
admet-184	50	13	fifth	fifth	ADJ
admet-184	50	14	of	of	ADP
admet-184	50	15	the	the	DET
admet-184	50	16	cranial	cranial	ADJ
admet-184	50	17	nerves	nerve	NOUN
admet-184	50	18	.	.	PUNCT
admet-184	51	1	numerous	numerous	ADJ
admet-184	51	2	intraepithelial	intraepithelial	ADJ
admet-184	51	3	trigeminal	trigeminal	ADJ
admet-184	51	4	fibres	fibre	NOUN
admet-184	51	5	are	be	AUX
admet-184	51	6	located	locate	VERB
admet-184	51	7	near	near	ADP
admet-184	51	8	the	the	DET
admet-184	51	9	basal	basal	ADJ
admet-184	51	10	region	region	NOUN
admet-184	51	11	of	of	ADP
admet-184	51	12	the	the	DET
admet-184	51	13	epithelium	epithelium	NOUN
admet-184	51	14	;	;	PUNCT
admet-184	51	15	some	some	PRON
admet-184	51	16	of	of	ADP
admet-184	51	17	them	they	PRON
admet-184	51	18	extending	extend	VERB
admet-184	51	19	outward	outward	ADV
admet-184	51	20	to	to	PART
admet-184	51	21	nearly	nearly	ADV
admet-184	51	22	reach	reach	VERB
admet-184	51	23	the	the	DET
admet-184	51	24	epithelial	epithelial	ADJ
admet-184	51	25	surface	surface	NOUN
admet-184	51	26	stopping	stop	VERB
admet-184	51	27	at	at	ADP
admet-184	51	28	the	the	DET
admet-184	51	29	line	line	NOUN
admet-184	51	30	of	of	ADP
admet-184	51	31	tight	tight	ADJ
admet-184	51	32	junctions	junction	NOUN
admet-184	51	33	about	about	ADV
admet-184	51	34	1	1	NUM
admet-184	51	35	µm	µm	NOUN
admet-184	51	36	from	from	ADP
admet-184	51	37	the	the	DET
admet-184	51	38	surface	surface	NOUN
admet-184	52	1	[	[	X
admet-184	52	2	22	22	NUM
admet-184	52	3	]	]	PUNCT
admet-184	52	4	.	.	PUNCT
admet-184	53	1	the	the	DET
admet-184	53	2	largely	largely	ADV
admet-184	53	3	branched	branched	ADJ
admet-184	53	4	trigeminal	trigeminal	ADJ
admet-184	53	5	nerve	nerve	NOUN
admet-184	53	6	projects	project	NOUN
admet-184	53	7	mainly	mainly	ADV
admet-184	53	8	but	but	CCONJ
admet-184	53	9	not	not	PART
admet-184	53	10	exclusively	exclusively	ADV
admet-184	53	11	to	to	ADP
admet-184	53	12	the	the	DET
admet-184	53	13	brainstem	brainstem	NOUN
admet-184	53	14	and	and	CCONJ
admet-184	53	15	is	be	AUX
admet-184	53	16	highly	highly	ADV
admet-184	53	17	implicated	implicate	VERB
admet-184	53	18	into	into	ADP
admet-184	53	19	n2b	n2b	PROPN
admet-184	53	20	transport	transport	NOUN
admet-184	54	1	[	[	X
admet-184	54	2	22,23	22,23	NOUN
admet-184	54	3	]	]	PUNCT
admet-184	54	4	.	.	PUNCT
admet-184	55	1	the	the	DET
admet-184	55	2	respiratory	respiratory	ADJ
admet-184	55	3	epithelium	epithelium	NOUN
admet-184	55	4	has	have	VERB
admet-184	55	5	a	a	DET
admet-184	55	6	large	large	ADJ
admet-184	55	7	surface	surface	NOUN
admet-184	55	8	and	and	CCONJ
admet-184	55	9	is	be	AUX
admet-184	55	10	highly	highly	ADV
admet-184	55	11	perfused	perfuse	VERB
admet-184	55	12	;	;	PUNCT
admet-184	55	13	hence	hence	ADV
admet-184	55	14	well	well	ADV
admet-184	55	15	suitable	suitable	ADJ
admet-184	55	16	for	for	ADP
admet-184	55	17	the	the	DET
admet-184	55	18	systemic	systemic	ADJ
admet-184	55	19	absorption	absorption	NOUN
admet-184	55	20	of	of	ADP
admet-184	55	21	drugs	drug	NOUN
admet-184	55	22	[	[	X
admet-184	55	23	24	24	NUM
admet-184	55	24	]	]	PUNCT
admet-184	55	25	.	.	PUNCT
admet-184	56	1	figure	figure	NOUN
admet-184	56	2	1	1	NUM
admet-184	56	3	.	.	PUNCT
admet-184	57	1	the	the	DET
admet-184	57	2	anatomy	anatomy	NOUN
admet-184	57	3	of	of	ADP
admet-184	57	4	the	the	DET
admet-184	57	5	human	human	ADJ
admet-184	57	6	nasal	nasal	PROPN
admet-184	57	7	cavity	cavity	NOUN
admet-184	57	8	.	.	PUNCT
admet-184	58	1	the	the	DET
admet-184	58	2	olfactory	olfactory	NOUN
admet-184	58	3	region	region	NOUN
admet-184	58	4	permits	permit	VERB
admet-184	58	5	the	the	DET
admet-184	58	6	transport	transport	NOUN
admet-184	58	7	of	of	ADP
admet-184	58	8	apis	apis	PROPN
admet-184	58	9	to	to	ADP
admet-184	58	10	the	the	DET
admet-184	58	11	csf	csf	NOUN
admet-184	58	12	and	and	CCONJ
admet-184	58	13	the	the	DET
admet-184	58	14	olfactory	olfactory	NOUN
admet-184	58	15	bulb	bulb	NOUN
admet-184	58	16	.	.	PUNCT
admet-184	59	1	(	(	PUNCT
admet-184	59	2	a	a	X
admet-184	59	3	)	)	PUNCT
admet-184	59	4	frontal	frontal	ADJ
admet-184	59	5	view	view	NOUN
admet-184	59	6	with	with	ADP
admet-184	59	7	inferior	inferior	ADJ
admet-184	59	8	,	,	PUNCT
admet-184	59	9	middle	middle	ADJ
admet-184	59	10	and	and	CCONJ
admet-184	59	11	superior	superior	ADJ
admet-184	59	12	turbinate	turbinate	NOUN
admet-184	59	13	.	.	PUNCT
admet-184	60	1	(	(	PUNCT
admet-184	60	2	b	b	X
admet-184	60	3	)	)	PUNCT
admet-184	60	4	lateral	lateral	ADJ
admet-184	60	5	view	view	NOUN
admet-184	60	6	with	with	ADP
admet-184	60	7	cribriform	cribriform	NOUN
admet-184	60	8	plate	plate	NOUN
admet-184	60	9	,	,	PUNCT
admet-184	60	10	olfactory	olfactory	NOUN
admet-184	60	11	bulb	bulb	NOUN
admet-184	60	12	and	and	CCONJ
admet-184	60	13	csf	csf	ADJ
admet-184	60	14	in	in	ADP
admet-184	60	15	close	close	ADJ
admet-184	60	16	vicinity	vicinity	NOUN
admet-184	60	17	to	to	ADP
admet-184	60	18	the	the	DET
admet-184	60	19	olfactory	olfactory	ADJ
admet-184	60	20	region	region	NOUN
admet-184	60	21	.	.	PUNCT
admet-184	61	1	the	the	DET
admet-184	61	2	nasopharynx	nasopharynx	NOUN
admet-184	61	3	-	-	PUNCT
admet-184	61	4	associated	associate	VERB
admet-184	61	5	lymphatic	lymphatic	ADJ
admet-184	61	6	tissue	tissue	NOUN
admet-184	61	7	(	(	PUNCT
admet-184	61	8	nalt	nalt	NOUN
admet-184	61	9	)	)	PUNCT
admet-184	61	10	has	have	VERB
admet-184	61	11	immunological	immunological	ADJ
admet-184	61	12	functions	function	NOUN
admet-184	61	13	and	and	CCONJ
admet-184	61	14	is	be	AUX
admet-184	61	15	located	locate	VERB
admet-184	61	16	in	in	ADP
admet-184	61	17	lower	low	ADJ
admet-184	61	18	part	part	NOUN
admet-184	61	19	of	of	ADP
admet-184	61	20	the	the	DET
admet-184	61	21	nasal	nasal	ADJ
admet-184	61	22	cavity	cavity	NOUN
admet-184	61	23	close	close	ADJ
admet-184	61	24	to	to	ADP
admet-184	61	25	the	the	DET
admet-184	61	26	nasopharynx	nasopharynx	NOUN
admet-184	61	27	.	.	PUNCT
admet-184	62	1	the	the	DET
admet-184	62	2	olfactory	olfactory	NOUN
admet-184	62	3	cleft	cleave	VERB
admet-184	62	4	at	at	ADP
admet-184	62	5	the	the	DET
admet-184	62	6	roof	roof	NOUN
admet-184	62	7	of	of	ADP
admet-184	62	8	the	the	DET
admet-184	62	9	nasal	nasal	ADJ
admet-184	62	10	cavity	cavity	NOUN
admet-184	62	11	up	up	ADP
admet-184	62	12	to	to	ADP
admet-184	62	13	the	the	DET
admet-184	62	14	superior	superior	ADJ
admet-184	62	15	parts	part	NOUN
admet-184	62	16	of	of	ADP
admet-184	62	17	the	the	DET
admet-184	62	18	turbinates	turbinate	NOUN
admet-184	62	19	is	be	AUX
admet-184	62	20	covered	cover	VERB
admet-184	62	21	with	with	ADP
admet-184	62	22	olfactory	olfactory	ADJ
admet-184	62	23	epithelium	epithelium	NOUN
admet-184	62	24	.	.	PUNCT
admet-184	63	1	in	in	ADP
admet-184	63	2	humans	human	NOUN
admet-184	63	3	the	the	DET
admet-184	63	4	olfactory	olfactory	ADJ
admet-184	63	5	region	region	NOUN
admet-184	63	6	comprises	comprise	VERB
admet-184	63	7	up	up	ADP
admet-184	63	8	to	to	PART
admet-184	63	9	10	10	NUM
admet-184	63	10	%	%	NOUN
admet-184	63	11	of	of	ADP
admet-184	63	12	the	the	DET
admet-184	63	13	surface	surface	NOUN
admet-184	63	14	area	area	NOUN
admet-184	63	15	of	of	ADP
admet-184	63	16	the	the	DET
admet-184	63	17	nasal	nasal	ADJ
admet-184	63	18	epithelium	epithelium	NOUN
admet-184	63	19	while	while	SCONJ
admet-184	63	20	accounting	account	VERB
admet-184	63	21	for	for	ADP
admet-184	63	22	about	about	ADV
admet-184	63	23	30	30	NUM
admet-184	63	24	%	%	NOUN
admet-184	63	25	of	of	ADP
admet-184	63	26	the	the	DET
admet-184	63	27	surface	surface	NOUN
admet-184	63	28	area	area	NOUN
admet-184	63	29	in	in	ADP
admet-184	63	30	rodents	rodent	NOUN
admet-184	63	31	[	[	X
admet-184	63	32	18	18	NUM
admet-184	63	33	]	]	PUNCT
admet-184	63	34	.	.	PUNCT
admet-184	64	1	the	the	DET
admet-184	64	2	olfactory	olfactory	NOUN
admet-184	64	3	epithelium	epithelium	NOUN
admet-184	64	4	is	be	AUX
admet-184	64	5	formed	form	VERB
admet-184	64	6	by	by	ADP
admet-184	64	7	columnar	columnar	ADJ
admet-184	64	8	epithelial	epithelial	ADJ
admet-184	64	9	cells	cell	NOUN
admet-184	64	10	,	,	PUNCT
admet-184	64	11	olfactory	olfactory	ADJ
admet-184	64	12	neurons	neuron	NOUN
admet-184	64	13	,	,	PUNCT
admet-184	64	14	supporting	support	VERB
admet-184	64	15	cells	cell	NOUN
admet-184	64	16	,	,	PUNCT
admet-184	64	17	basal	basal	ADJ
admet-184	64	18	cells	cell	NOUN
admet-184	64	19	and	and	CCONJ
admet-184	64	20	bowman	bowman	NOUN
admet-184	64	21	’s	’s	PART
admet-184	64	22	glands	gland	NOUN
admet-184	64	23	[	[	X
admet-184	64	24	19	19	NUM
admet-184	64	25	]	]	PUNCT
admet-184	64	26	.	.	PUNCT
admet-184	65	1	olfactory	olfactory	ADJ
admet-184	65	2	neurons	neuron	NOUN
admet-184	65	3	are	be	AUX
admet-184	65	4	the	the	DET
admet-184	65	5	only	only	ADJ
admet-184	65	6	neurons	neuron	NOUN
admet-184	65	7	having	have	VERB
admet-184	65	8	their	their	PRON
admet-184	65	9	cell	cell	NOUN
admet-184	65	10	bodies	body	NOUN
admet-184	65	11	located	locate	VERB
admet-184	65	12	in	in	ADP
admet-184	65	13	a	a	DET
admet-184	65	14	distal	distal	ADJ
admet-184	65	15	epithelium	epithelium	NOUN
admet-184	65	16	and	and	CCONJ
admet-184	65	17	their	their	PRON
admet-184	65	18	non	non	ADJ
admet-184	65	19	-	-	ADJ
admet-184	65	20	motile	motile	ADJ
admet-184	65	21	cilia	cilia	NOUN
admet-184	65	22	processes	process	NOUN
admet-184	65	23	extend	extend	VERB
admet-184	65	24	into	into	ADP
admet-184	65	25	the	the	DET
admet-184	65	26	mucus	mucus	NOUN
admet-184	65	27	hence	hence	ADV
admet-184	65	28	being	be	AUX
admet-184	65	29	in	in	ADP
admet-184	65	30	direct	direct	ADJ
admet-184	65	31	contact	contact	NOUN
admet-184	65	32	to	to	ADP
admet-184	65	33	the	the	DET
admet-184	65	34	environment	environment	NOUN
admet-184	65	35	(	(	PUNCT
admet-184	65	36	figure	figure	NOUN
admet-184	65	37	2	2	NUM
admet-184	65	38	)	)	PUNCT
admet-184	65	39	.	.	PUNCT
admet-184	66	1	turbulences	turbulence	NOUN
admet-184	66	2	at	at	ADP
admet-184	66	3	the	the	DET
admet-184	66	4	olfactory	olfactory	NOUN
admet-184	66	5	cleft	cleft	NOUN
admet-184	66	6	increase	increase	VERB
admet-184	66	7	the	the	DET
admet-184	66	8	residence	residence	NOUN
admet-184	66	9	time	time	NOUN
admet-184	66	10	of	of	ADP
admet-184	66	11	the	the	DET
admet-184	66	12	inspired	inspire	VERB
admet-184	66	13	air	air	NOUN
admet-184	66	14	to	to	PART
admet-184	66	15	increase	increase	VERB
admet-184	66	16	the	the	DET
admet-184	66	17	interaction	interaction	NOUN
admet-184	66	18	of	of	ADP
admet-184	66	19	the	the	DET
admet-184	66	20	olfactory	olfactory	ADJ
admet-184	66	21	receptors	receptor	NOUN
admet-184	66	22	with	with	ADP
admet-184	66	23	odorants	odorant	NOUN
admet-184	66	24	.	.	PUNCT
admet-184	67	1	hence	hence	ADV
admet-184	67	2	,	,	PUNCT
admet-184	67	3	small	small	ADJ
admet-184	67	4	number	number	NOUN
admet-184	67	5	of	of	ADP
admet-184	67	6	odorant	odorant	ADJ
admet-184	67	7	substances	substance	NOUN
admet-184	67	8	can	can	AUX
admet-184	67	9	be	be	AUX
admet-184	67	10	detected	detect	VERB
admet-184	67	11	[	[	X
admet-184	67	12	19	19	NUM
admet-184	67	13	]	]	PUNCT
admet-184	67	14	.	.	PUNCT
admet-184	68	1	the	the	DET
admet-184	68	2	unmyelinated	unmyelinated	ADJ
admet-184	68	3	axons	axon	NOUN
admet-184	68	4	of	of	ADP
admet-184	68	5	olfactory	olfactory	ADJ
admet-184	68	6	neurons	neuron	NOUN
admet-184	68	7	spread	spread	VERB
admet-184	68	8	through	through	ADP
admet-184	68	9	the	the	DET
admet-184	68	10	basal	basal	ADJ
admet-184	68	11	lamina	lamina	NOUN
admet-184	68	12	and	and	CCONJ
admet-184	68	13	form	form	VERB
admet-184	68	14	the	the	DET
admet-184	68	15	fila	fila	PROPN
admet-184	68	16	olfactoria	olfactoria	PROPN
admet-184	68	17	nerve	nerve	NOUN
admet-184	68	18	bundles	bundle	NOUN
admet-184	68	19	enclosed	enclose	VERB
admet-184	68	20	by	by	ADP
admet-184	68	21	olfactory	olfactory	NOUN
admet-184	68	22	ensheathing	ensheathing	NOUN
admet-184	68	23	cells	cell	NOUN
admet-184	68	24	and	and	CCONJ
admet-184	68	25	olfactory	olfactory	ADJ
admet-184	68	26	nerve	nerve	NOUN
admet-184	68	27	fibroblasts	fibroblast	NOUN
admet-184	68	28	[	[	X
admet-184	68	29	25	25	NUM
admet-184	68	30	]	]	PUNCT
admet-184	68	31	.	.	PUNCT
admet-184	69	1	the	the	DET
admet-184	69	2	ensheathed	ensheathed	ADJ
admet-184	69	3	nerve	nerve	NOUN
admet-184	69	4	bundles	bundle	NOUN
admet-184	69	5	travel	travel	VERB
admet-184	69	6	through	through	ADP
admet-184	69	7	the	the	DET
admet-184	69	8	cribriform	cribriform	ADJ
admet-184	69	9	plate	plate	NOUN
admet-184	69	10	of	of	ADP
admet-184	69	11	the	the	DET
admet-184	69	12	ethmoid	ethmoid	NOUN
admet-184	69	13	bone	bone	NOUN
admet-184	69	14	into	into	ADP
admet-184	69	15	the	the	DET
admet-184	69	16	cns	cns	NOUN
admet-184	69	17	and	and	CCONJ
admet-184	69	18	terminate	terminate	NOUN
admet-184	69	19	at	at	ADP
admet-184	69	20	the	the	DET
admet-184	69	21	olfactory	olfactory	NOUN
admet-184	69	22	bulb	bulb	NOUN
admet-184	69	23	that	that	DET
admet-184	69	24	project	project	VERB
admet-184	69	25	directly	directly	ADV
admet-184	69	26	to	to	ADP
admet-184	69	27	the	the	DET
admet-184	69	28	piriform	piriform	NOUN
admet-184	69	29	cortex	cortex	NOUN
admet-184	69	30	,	,	PUNCT
admet-184	69	31	amygdala	amygdala	NOUN
admet-184	69	32	,	,	PUNCT
admet-184	69	33	entorhinal	entorhinal	ADJ
admet-184	69	34	cortex	cortex	NOUN
admet-184	69	35	and	and	CCONJ
admet-184	69	36	olfactory	olfactory	ADJ
admet-184	69	37	nuclei	nucleus	NOUN
admet-184	69	38	[	[	X
admet-184	69	39	26	26	NUM
admet-184	69	40	]	]	PUNCT
admet-184	69	41	.	.	PUNCT
admet-184	70	1	compared	compare	VERB
admet-184	70	2	to	to	ADP
admet-184	70	3	the	the	DET
admet-184	70	4	respiratory	respiratory	ADJ
admet-184	70	5	epithelium	epithelium	NOUN
admet-184	70	6	the	the	DET
admet-184	70	7	olfactory	olfactory	NOUN
admet-184	70	8	region	region	NOUN
admet-184	70	9	is	be	AUX
admet-184	70	10	less	less	ADV
admet-184	70	11	perfused	perfused	ADJ
admet-184	70	12	,	,	PUNCT
admet-184	70	13	but	but	CCONJ
admet-184	70	14	still	still	ADV
admet-184	70	15	well	well	ADV
admet-184	70	16	vasculated	vasculate	VERB
admet-184	70	17	.	.	PUNCT
admet-184	71	1	the	the	DET
admet-184	71	2	serous	serous	ADJ
admet-184	71	3	mucus	mucus	NOUN
admet-184	71	4	produced	produce	VERB
admet-184	71	5	by	by	ADP
admet-184	71	6	the	the	DET
admet-184	71	7	bowman	bowman	PROPN
admet-184	71	8	's	's	PART
admet-184	71	9	admet	admet	PROPN
admet-184	71	10	&	&	CCONJ
admet-184	71	11	dmpk	dmpk	PROPN
admet-184	71	12	3(3	3(3	NUM
admet-184	71	13	)	)	PUNCT
admet-184	71	14	(	(	PUNCT
admet-184	71	15	2015	2015	NUM
admet-184	71	16	)	)	PUNCT
admet-184	71	17	190	190	NUM
admet-184	71	18	-	-	SYM
admet-184	71	19	202	202	NUM
admet-184	71	20	intranasal	intranasal	ADJ
admet-184	71	21	insulin	insulin	NOUN
admet-184	71	22	as	as	ADP
admet-184	71	23	hope	hope	NOUN
admet-184	71	24	for	for	ADP
admet-184	71	25	ad	ad	NOUN
admet-184	71	26	?	?	PUNCT
admet-184	72	1	doi	doi	NOUN
admet-184	72	2	:	:	PUNCT
admet-184	72	3	10.5599	10.5599	NUM
admet-184	72	4	/	/	SYM
admet-184	72	5	admet.3.3.184	admet.3.3.184	ADP
admet-184	72	6	193	193	NUM
admet-184	72	7	glands	gland	NOUN
admet-184	72	8	is	be	AUX
admet-184	72	9	not	not	PART
admet-184	72	10	well	well	ADV
admet-184	72	11	characterized	characterize	VERB
admet-184	72	12	in	in	ADP
admet-184	72	13	the	the	DET
admet-184	72	14	literature	literature	NOUN
admet-184	72	15	.	.	PUNCT
admet-184	73	1	the	the	DET
admet-184	73	2	lamina	lamina	ADJ
admet-184	73	3	propria	propria	PROPN
admet-184	73	4	underneath	underneath	ADP
admet-184	73	5	the	the	DET
admet-184	73	6	olfactory	olfactory	NOUN
admet-184	73	7	epithelium	epithelium	NOUN
admet-184	73	8	harbours	harbour	VERB
admet-184	73	9	blood	blood	NOUN
admet-184	73	10	and	and	CCONJ
admet-184	73	11	lymphatic	lymphatic	ADJ
admet-184	73	12	vessels	vessel	NOUN
admet-184	73	13	in	in	ADP
admet-184	73	14	addition	addition	NOUN
admet-184	73	15	to	to	ADP
admet-184	73	16	immune	immune	ADJ
admet-184	73	17	cells	cell	NOUN
admet-184	73	18	connected	connect	VERB
admet-184	73	19	to	to	ADP
admet-184	73	20	the	the	DET
admet-184	73	21	deep	deep	ADJ
admet-184	73	22	cervical	cervical	ADJ
admet-184	73	23	lymph	lymph	NOUN
admet-184	73	24	.	.	PUNCT
admet-184	74	1	figure	figure	NOUN
admet-184	74	2	2	2	NUM
admet-184	74	3	.	.	NUM
admet-184	74	4	postulated	postulate	VERB
admet-184	74	5	n2b	n2b	PROPN
admet-184	74	6	transport	transport	NOUN
admet-184	74	7	mechanism	mechanism	NOUN
admet-184	74	8	:	:	PUNCT
admet-184	74	9	dispersed	disperse	VERB
admet-184	74	10	drug	drug	NOUN
admet-184	74	11	particles	particle	NOUN
admet-184	74	12	(	(	PUNCT
admet-184	74	13	coloured	colour	VERB
admet-184	74	14	in	in	ADP
admet-184	74	15	green	green	NOUN
admet-184	74	16	)	)	PUNCT
admet-184	74	17	are	be	AUX
admet-184	74	18	inspired	inspire	VERB
admet-184	74	19	with	with	ADP
admet-184	74	20	the	the	DET
admet-184	74	21	aid	aid	NOUN
admet-184	74	22	of	of	ADP
admet-184	74	23	a	a	DET
admet-184	74	24	nasal	nasal	ADJ
admet-184	74	25	pump	pump	NOUN
admet-184	74	26	spray	spray	NOUN
admet-184	74	27	or	or	CCONJ
admet-184	74	28	an	an	DET
admet-184	74	29	aerosol	aerosol	NOUN
admet-184	74	30	generator	generator	NOUN
admet-184	74	31	.	.	PUNCT
admet-184	75	1	drug	drug	NOUN
admet-184	75	2	molecules	molecule	NOUN
admet-184	75	3	depositing	deposit	VERB
admet-184	75	4	at	at	ADP
admet-184	75	5	the	the	DET
admet-184	75	6	olfactory	olfactory	ADJ
admet-184	75	7	region	region	NOUN
admet-184	75	8	diffuse	diffuse	VERB
admet-184	75	9	through	through	ADP
admet-184	75	10	extracellular	extracellular	ADJ
admet-184	75	11	pathways	pathway	NOUN
admet-184	75	12	(	(	PUNCT
admet-184	75	13	green	green	ADJ
admet-184	75	14	arrows	arrow	NOUN
admet-184	75	15	)	)	PUNCT
admet-184	75	16	to	to	ADP
admet-184	75	17	the	the	DET
admet-184	75	18	csf	csf	NOUN
admet-184	75	19	(	(	PUNCT
admet-184	75	20	see	see	VERB
admet-184	75	21	left	left	ADJ
admet-184	75	22	side	side	NOUN
admet-184	75	23	)	)	PUNCT
admet-184	75	24	or	or	CCONJ
admet-184	75	25	being	be	AUX
admet-184	75	26	transported	transport	VERB
admet-184	75	27	via	via	ADP
admet-184	75	28	intracellular	intracellular	ADJ
admet-184	75	29	pathways	pathway	NOUN
admet-184	75	30	to	to	ADP
admet-184	75	31	the	the	DET
admet-184	75	32	olfactory	olfactory	NOUN
admet-184	75	33	bulb	bulb	NOUN
admet-184	75	34	(	(	PUNCT
admet-184	75	35	see	see	VERB
admet-184	75	36	right	right	ADJ
admet-184	75	37	side	side	NOUN
admet-184	75	38	)	)	PUNCT
admet-184	75	39	and	and	CCONJ
admet-184	75	40	from	from	ADP
admet-184	75	41	here	here	ADV
admet-184	75	42	to	to	ADP
admet-184	75	43	other	other	ADJ
admet-184	75	44	parts	part	NOUN
admet-184	75	45	of	of	ADP
admet-184	75	46	the	the	DET
admet-184	75	47	cns	cns	PROPN
admet-184	75	48	.	.	PUNCT
admet-184	76	1	absorption	absorption	NOUN
admet-184	76	2	and	and	CCONJ
admet-184	76	3	transport	transport	NOUN
admet-184	76	4	mechanism	mechanism	NOUN
admet-184	76	5	of	of	ADP
admet-184	76	6	the	the	DET
admet-184	76	7	n2b	n2b	PROPN
admet-184	76	8	route	route	NOUN
admet-184	76	9	although	although	SCONJ
admet-184	76	10	,	,	PUNCT
admet-184	76	11	numerous	numerous	ADJ
admet-184	76	12	studies	study	NOUN
admet-184	76	13	have	have	AUX
admet-184	76	14	demonstrated	demonstrate	VERB
admet-184	76	15	central	central	ADJ
admet-184	76	16	effects	effect	NOUN
admet-184	76	17	of	of	ADP
admet-184	76	18	n2b	n2b	PROPN
admet-184	76	19	delivered	deliver	VERB
admet-184	76	20	drugs	drug	NOUN
admet-184	76	21	in	in	ADP
admet-184	76	22	rodents	rodent	NOUN
admet-184	76	23	,	,	PUNCT
admet-184	76	24	most	most	ADJ
admet-184	76	25	of	of	ADP
admet-184	76	26	these	these	DET
admet-184	76	27	studies	study	NOUN
admet-184	76	28	did	do	AUX
admet-184	76	29	not	not	PART
admet-184	76	30	show	show	VERB
admet-184	76	31	pharmacokinetic	pharmacokinetic	ADJ
admet-184	76	32	(	(	PUNCT
admet-184	76	33	pk	pk	NOUN
admet-184	76	34	)	)	PUNCT
admet-184	76	35	data	datum	NOUN
admet-184	76	36	or	or	CCONJ
admet-184	76	37	evidence	evidence	NOUN
admet-184	76	38	for	for	ADP
admet-184	76	39	brain	brain	NOUN
admet-184	76	40	uptake	uptake	ADJ
admet-184	76	41	.	.	PUNCT
admet-184	77	1	hence	hence	ADV
admet-184	77	2	,	,	PUNCT
admet-184	77	3	the	the	DET
admet-184	77	4	pk	pk	NOUN
admet-184	77	5	and	and	CCONJ
admet-184	77	6	transport	transport	NOUN
admet-184	77	7	mechanism	mechanism	NOUN
admet-184	77	8	is	be	AUX
admet-184	77	9	still	still	ADV
admet-184	77	10	far	far	ADV
admet-184	77	11	from	from	ADP
admet-184	77	12	being	be	AUX
admet-184	77	13	elucidated	elucidate	VERB
admet-184	77	14	.	.	PUNCT
admet-184	78	1	it	it	PRON
admet-184	78	2	appears	appear	VERB
admet-184	78	3	that	that	SCONJ
admet-184	78	4	intranasal	intranasal	ADJ
admet-184	78	5	delivery	delivery	NOUN
admet-184	78	6	is	be	AUX
admet-184	78	7	a	a	DET
admet-184	78	8	combination	combination	NOUN
admet-184	78	9	of	of	ADP
admet-184	78	10	different	different	ADJ
admet-184	78	11	pathways	pathway	NOUN
admet-184	79	1	[	[	X
admet-184	79	2	18	18	NUM
admet-184	79	3	]	]	PUNCT
admet-184	79	4	.	.	PUNCT
admet-184	80	1	it	it	PRON
admet-184	80	2	was	be	AUX
admet-184	80	3	found	find	VERB
admet-184	80	4	that	that	SCONJ
admet-184	80	5	crossing	crossing	NOUN
admet-184	80	6	of	of	ADP
admet-184	80	7	the	the	DET
admet-184	80	8	epithelial	epithelial	ADJ
admet-184	80	9	barrier	barrier	NOUN
admet-184	80	10	can	can	AUX
admet-184	80	11	include	include	VERB
admet-184	80	12	intracellular	intracellular	ADJ
admet-184	80	13	or	or	CCONJ
admet-184	80	14	extracellular	extracellular	ADJ
admet-184	80	15	pathways	pathway	NOUN
admet-184	80	16	.	.	PUNCT
admet-184	81	1	intracellular	intracellular	ADJ
admet-184	81	2	pathways	pathway	NOUN
admet-184	81	3	across	across	ADP
admet-184	81	4	the	the	DET
admet-184	81	5	olfactory	olfactory	ADJ
admet-184	81	6	epithelium	epithelium	NOUN
admet-184	81	7	include	include	VERB
admet-184	81	8	endocytosis	endocytosis	NOUN
admet-184	81	9	into	into	ADP
admet-184	81	10	olfactory	olfactory	ADJ
admet-184	81	11	neurons	neuron	NOUN
admet-184	81	12	shown	show	VERB
admet-184	81	13	for	for	ADP
admet-184	81	14	several	several	ADJ
admet-184	81	15	viruses	virus	NOUN
admet-184	81	16	and	and	CCONJ
admet-184	81	17	some	some	DET
admet-184	81	18	proteins	protein	NOUN
admet-184	81	19	like	like	ADP
admet-184	81	20	peroxidase	peroxidase	NOUN
admet-184	81	21	or	or	CCONJ
admet-184	81	22	albumin	albumin	NOUN
admet-184	81	23	[	[	X
admet-184	81	24	27	27	NUM
admet-184	81	25	-	-	SYM
admet-184	81	26	32	32	NUM
admet-184	81	27	]	]	PUNCT
admet-184	81	28	or	or	CCONJ
admet-184	81	29	transcytosis	transcytosis	NOUN
admet-184	81	30	across	across	ADP
admet-184	81	31	supporting	support	VERB
admet-184	81	32	cells	cell	NOUN
admet-184	81	33	to	to	ADP
admet-184	81	34	the	the	DET
admet-184	81	35	lamina	lamina	ADJ
admet-184	81	36	propria	propria	PROPN
admet-184	81	37	.	.	PUNCT
admet-184	82	1	in	in	ADP
admet-184	82	2	addition	addition	NOUN
admet-184	82	3	,	,	PUNCT
admet-184	82	4	the	the	DET
admet-184	82	5	intracellular	intracellular	ADJ
admet-184	82	6	uptake	uptake	NOUN
admet-184	82	7	by	by	ADP
admet-184	82	8	endocytosis	endocytosis	NOUN
admet-184	82	9	and	and	CCONJ
admet-184	82	10	transcytosis	transcytosis	NOUN
admet-184	82	11	across	across	ADP
admet-184	82	12	the	the	DET
admet-184	82	13	respiratory	respiratory	ADJ
admet-184	82	14	epithelium	epithelium	NOUN
admet-184	82	15	into	into	ADP
admet-184	82	16	trigeminal	trigeminal	ADJ
admet-184	82	17	nerve	nerve	NOUN
admet-184	82	18	processes	process	NOUN
admet-184	82	19	or	or	CCONJ
admet-184	82	20	basal	basal	ADJ
admet-184	82	21	lamina	lamina	PROPN
admet-184	82	22	,	,	PUNCT
admet-184	82	23	respectively	respectively	ADV
admet-184	82	24	,	,	PUNCT
admet-184	82	25	has	have	AUX
admet-184	82	26	been	be	AUX
admet-184	82	27	observed	observe	VERB
admet-184	82	28	[	[	X
admet-184	82	29	33,34	33,34	NOUN
admet-184	82	30	]	]	PUNCT
admet-184	82	31	.	.	PUNCT
admet-184	83	1	paracellular	paracellular	ADJ
admet-184	83	2	diffusion	diffusion	NOUN
admet-184	83	3	through	through	ADP
admet-184	83	4	epithelial	epithelial	ADJ
admet-184	83	5	tight	tight	ADJ
admet-184	83	6	junctions	junction	NOUN
admet-184	83	7	to	to	ADP
admet-184	83	8	the	the	DET
admet-184	83	9	underlying	underlying	ADJ
admet-184	83	10	basal	basal	NOUN
admet-184	83	11	lamina	lamina	NOUN
admet-184	83	12	is	be	AUX
admet-184	83	13	the	the	DET
admet-184	83	14	dominant	dominant	ADJ
admet-184	83	15	extracellular	extracellular	ADJ
admet-184	83	16	transport	transport	NOUN
admet-184	83	17	pathways	pathway	NOUN
admet-184	83	18	across	across	ADP
admet-184	83	19	either	either	CCONJ
admet-184	83	20	the	the	DET
admet-184	83	21	olfactory	olfactory	NOUN
admet-184	83	22	or	or	CCONJ
admet-184	83	23	respiratory	respiratory	ADJ
admet-184	83	24	epithelia	epithelia	NOUN
admet-184	83	25	(	(	PUNCT
admet-184	83	26	figure	figure	NOUN
admet-184	83	27	2	2	NUM
admet-184	83	28	)	)	PUNCT
admet-184	84	1	[	[	X
admet-184	84	2	18	18	NUM
admet-184	84	3	]	]	PUNCT
admet-184	84	4	.	.	PUNCT
admet-184	85	1	the	the	DET
admet-184	85	2	permeability	permeability	NOUN
admet-184	85	3	of	of	ADP
admet-184	85	4	the	the	DET
admet-184	85	5	nasal	nasal	ADJ
admet-184	85	6	epithelium	epithelium	NOUN
admet-184	85	7	is	be	AUX
admet-184	85	8	comparable	comparable	ADJ
admet-184	85	9	to	to	ADP
admet-184	85	10	the	the	DET
admet-184	85	11	intestinal	intestinal	ADJ
admet-184	85	12	epithelium	epithelium	NOUN
admet-184	85	13	[	[	X
admet-184	85	14	35	35	NUM
admet-184	85	15	]	]	PUNCT
admet-184	85	16	.	.	PUNCT
admet-184	86	1	the	the	DET
admet-184	86	2	use	use	NOUN
admet-184	86	3	of	of	ADP
admet-184	86	4	absorption	absorption	NOUN
admet-184	86	5	enhancers	enhancer	NOUN
admet-184	86	6	like	like	ADP
admet-184	86	7	the	the	DET
admet-184	86	8	natural	natural	ADJ
admet-184	86	9	polymer	polymer	NOUN
admet-184	86	10	chitosan	chitosan	NOUN
admet-184	86	11	or	or	CCONJ
admet-184	86	12	lipophilic	lipophilic	ADJ
admet-184	86	13	m.	m.	NOUN
admet-184	86	14	stützle	stützle	NOUN
admet-184	86	15	,	,	PUNCT
admet-184	86	16	j.	j.	PROPN
admet-184	86	17	flamm	flamm	PROPN
admet-184	86	18	,	,	PUNCT
admet-184	86	19	s.	s.	PROPN
admet-184	86	20	carle	carle	PROPN
admet-184	86	21	and	and	CCONJ
admet-184	86	22	k.	k.	PROPN
admet-184	86	23	schindowski	schindowski	PROPN
admet-184	86	24	admet	admet	PROPN
admet-184	86	25	&	&	CCONJ
admet-184	86	26	dmpk	dmpk	PROPN
admet-184	86	27	3(3	3(3	NUM
admet-184	86	28	)	)	PUNCT
admet-184	86	29	(	(	PUNCT
admet-184	86	30	2015	2015	NUM
admet-184	86	31	)	)	PUNCT
admet-184	86	32	190	190	NUM
admet-184	86	33	-	-	SYM
admet-184	86	34	202	202	NUM
admet-184	86	35	194	194	NUM
admet-184	86	36	additives	additive	NOUN
admet-184	86	37	can	can	AUX
admet-184	86	38	increase	increase	VERB
admet-184	86	39	the	the	DET
admet-184	86	40	paracellular	paracellular	ADJ
admet-184	86	41	passage	passage	NOUN
admet-184	86	42	[	[	X
admet-184	86	43	36	36	NUM
admet-184	86	44	]	]	PUNCT
admet-184	86	45	.	.	PUNCT
admet-184	87	1	after	after	SCONJ
admet-184	87	2	uptake	uptake	ADJ
admet-184	87	3	to	to	ADP
admet-184	87	4	or	or	CCONJ
admet-184	87	5	through	through	ADP
admet-184	87	6	the	the	DET
admet-184	87	7	epithelium	epithelium	NOUN
admet-184	87	8	,	,	PUNCT
admet-184	87	9	different	different	ADJ
admet-184	87	10	transport	transport	NOUN
admet-184	87	11	pathways	pathway	NOUN
admet-184	87	12	have	have	AUX
admet-184	87	13	been	be	AUX
admet-184	87	14	implicated	implicate	VERB
admet-184	87	15	.	.	PUNCT
admet-184	88	1	n2b	n2b	PROPN
admet-184	88	2	delivery	delivery	NOUN
admet-184	88	3	of	of	ADP
admet-184	88	4	radioactive	radioactive	NOUN
admet-184	88	5	labelled	label	VERB
admet-184	88	6	igf-1	igf-1	PRON
admet-184	88	7	and	and	CCONJ
admet-184	88	8	interferon-	interferon-	PROPN
admet-184	88	9	in	in	ADP
admet-184	88	10	rodents	rodent	NOUN
admet-184	88	11	and	and	CCONJ
admet-184	88	12	monkeys	monkey	NOUN
admet-184	88	13	seemed	seem	VERB
admet-184	88	14	to	to	PART
admet-184	88	15	occur	occur	VERB
admet-184	88	16	along	along	ADP
admet-184	88	17	trigeminal	trigeminal	ADJ
admet-184	88	18	and	and	CCONJ
admet-184	88	19	olfactory	olfactory	ADJ
admet-184	88	20	nerves	nerve	NOUN
admet-184	88	21	and	and	CCONJ
admet-184	88	22	to	to	PART
admet-184	88	23	reach	reach	VERB
admet-184	88	24	first	first	ADV
admet-184	88	25	the	the	DET
admet-184	88	26	brainstem	brainstem	NOUN
admet-184	88	27	and	and	CCONJ
admet-184	88	28	olfactory	olfactory	NOUN
admet-184	88	29	bulb	bulb	NOUN
admet-184	88	30	before	before	SCONJ
admet-184	88	31	the	the	DET
admet-184	88	32	proteins	protein	NOUN
admet-184	88	33	are	be	AUX
admet-184	88	34	distributed	distribute	VERB
admet-184	88	35	over	over	ADP
admet-184	88	36	the	the	DET
admet-184	88	37	cns	cns	NOUN
admet-184	89	1	[	[	X
admet-184	89	2	37,38	37,38	NOUN
admet-184	89	3	]	]	PUNCT
admet-184	89	4	.	.	PUNCT
admet-184	90	1	molecules	molecule	NOUN
admet-184	90	2	being	be	AUX
admet-184	90	3	taken	take	VERB
admet-184	90	4	-	-	PUNCT
admet-184	90	5	up	up	NOUN
admet-184	90	6	via	via	ADP
admet-184	90	7	intracellular	intracellular	ADJ
admet-184	90	8	pathways	pathway	NOUN
admet-184	90	9	continue	continue	VERB
admet-184	90	10	their	their	PRON
admet-184	90	11	passage	passage	NOUN
admet-184	90	12	via	via	ADP
admet-184	90	13	anterograde	anterograde	ADJ
admet-184	90	14	axonal	axonal	ADJ
admet-184	90	15	transport	transport	NOUN
admet-184	90	16	.	.	PUNCT
admet-184	91	1	peroxidase	peroxidase	PROPN
admet-184	91	2	is	be	AUX
admet-184	91	3	likely	likely	ADJ
admet-184	91	4	to	to	PART
admet-184	91	5	be	be	AUX
admet-184	91	6	purely	purely	ADV
admet-184	91	7	transported	transport	VERB
admet-184	91	8	with	with	ADP
admet-184	91	9	axonal	axonal	ADJ
admet-184	91	10	transport	transport	NOUN
admet-184	91	11	and	and	CCONJ
admet-184	91	12	kinetic	kinetic	ADJ
admet-184	91	13	studies	study	NOUN
admet-184	91	14	match	match	VERB
admet-184	91	15	very	very	ADV
admet-184	91	16	well	well	ADV
admet-184	91	17	with	with	ADP
admet-184	91	18	mathematical	mathematical	ADJ
admet-184	91	19	predictions	prediction	NOUN
admet-184	91	20	taking	take	VERB
admet-184	91	21	into	into	ADP
admet-184	91	22	account	account	NOUN
admet-184	91	23	the	the	DET
admet-184	91	24	transport	transport	NOUN
admet-184	91	25	rate	rate	NOUN
admet-184	91	26	[	[	X
admet-184	91	27	18	18	NUM
admet-184	91	28	]	]	PUNCT
admet-184	91	29	.	.	PUNCT
admet-184	92	1	drugs	drug	NOUN
admet-184	92	2	that	that	PRON
admet-184	92	3	have	have	AUX
admet-184	92	4	been	be	AUX
admet-184	92	5	taken	take	VERB
admet-184	92	6	-	-	PUNCT
admet-184	92	7	up	up	NOUN
admet-184	92	8	by	by	ADP
admet-184	92	9	transcellular	transcellular	NOUN
admet-184	92	10	diffusion	diffusion	NOUN
admet-184	92	11	and	and	CCONJ
admet-184	92	12	convection	convection	NOUN
admet-184	92	13	can	can	AUX
admet-184	92	14	be	be	AUX
admet-184	92	15	adsorbed	adsorb	VERB
admet-184	92	16	by	by	ADP
admet-184	92	17	the	the	DET
admet-184	92	18	lymphatic	lymphatic	ADJ
admet-184	92	19	or	or	CCONJ
admet-184	92	20	vascular	vascular	ADJ
admet-184	92	21	system	system	NOUN
admet-184	92	22	(	(	PUNCT
admet-184	92	23	and	and	CCONJ
admet-184	92	24	thereby	thereby	ADV
admet-184	92	25	having	have	VERB
admet-184	92	26	a	a	DET
admet-184	92	27	low	low	ADJ
admet-184	92	28	probability	probability	NOUN
admet-184	92	29	of	of	ADP
admet-184	92	30	entering	enter	VERB
admet-184	92	31	the	the	DET
admet-184	92	32	brain	brain	NOUN
admet-184	92	33	)	)	PUNCT
admet-184	92	34	or	or	CCONJ
admet-184	92	35	diffuse	diffuse	VERB
admet-184	92	36	to	to	PART
admet-184	92	37	perineural	perineural	ADJ
admet-184	92	38	or	or	CCONJ
admet-184	92	39	perivascular	perivascular	ADJ
admet-184	92	40	spaces	space	NOUN
admet-184	92	41	and	and	CCONJ
admet-184	92	42	thereby	thereby	ADV
admet-184	92	43	enter	enter	VERB
admet-184	92	44	the	the	DET
admet-184	92	45	cranial	cranial	ADJ
admet-184	92	46	compartment	compartment	NOUN
admet-184	92	47	.	.	PUNCT
admet-184	93	1	the	the	DET
admet-184	93	2	perineural	perineural	ADJ
admet-184	93	3	spaces	space	NOUN
admet-184	93	4	of	of	ADP
admet-184	93	5	the	the	DET
admet-184	93	6	olfactory	olfactory	NOUN
admet-184	93	7	and	and	CCONJ
admet-184	93	8	trigeminal	trigeminal	ADJ
admet-184	93	9	nerves	nerve	NOUN
admet-184	93	10	seem	seem	VERB
admet-184	93	11	to	to	PART
admet-184	93	12	allow	allow	VERB
admet-184	93	13	transport	transport	NOUN
admet-184	93	14	to	to	ADP
admet-184	93	15	the	the	DET
admet-184	93	16	csf	csf	NOUN
admet-184	93	17	of	of	ADP
admet-184	93	18	the	the	DET
admet-184	93	19	subarachnoid	subarachnoid	ADJ
admet-184	93	20	space	space	NOUN
admet-184	93	21	[	[	X
admet-184	93	22	39	39	NUM
admet-184	93	23	]	]	PUNCT
admet-184	93	24	.	.	PUNCT
admet-184	94	1	however	however	ADV
admet-184	94	2	,	,	PUNCT
admet-184	94	3	some	some	DET
admet-184	94	4	studies	study	NOUN
admet-184	94	5	suggest	suggest	VERB
admet-184	94	6	that	that	SCONJ
admet-184	94	7	n2b	n2b	NOUN
admet-184	94	8	transported	transport	VERB
admet-184	94	9	substances	substance	NOUN
admet-184	94	10	may	may	AUX
admet-184	94	11	be	be	AUX
admet-184	94	12	present	present	ADJ
admet-184	94	13	in	in	ADP
admet-184	94	14	the	the	DET
admet-184	94	15	brain	brain	NOUN
admet-184	94	16	without	without	ADP
admet-184	94	17	being	be	AUX
admet-184	94	18	detectable	detectable	ADJ
admet-184	94	19	in	in	ADP
admet-184	94	20	the	the	DET
admet-184	94	21	csf	csf	NOUN
admet-184	95	1	[	[	X
admet-184	95	2	37	37	NUM
admet-184	95	3	]	]	PUNCT
admet-184	95	4	.	.	PUNCT
admet-184	96	1	mathematical	mathematical	ADJ
admet-184	96	2	predictions	prediction	NOUN
admet-184	96	3	,	,	PUNCT
admet-184	96	4	however	however	ADV
admet-184	96	5	,	,	PUNCT
admet-184	96	6	strongly	strongly	ADV
admet-184	96	7	suggest	suggest	VERB
admet-184	96	8	that	that	SCONJ
admet-184	96	9	convection	convection	NOUN
admet-184	96	10	/	/	SYM
admet-184	96	11	bulk	bulk	ADJ
admet-184	96	12	flow	flow	NOUN
admet-184	96	13	along	along	ADP
admet-184	96	14	olfactory	olfactory	ADJ
admet-184	96	15	and	and	CCONJ
admet-184	96	16	trigeminal	trigeminal	ADJ
admet-184	96	17	nerves	nerve	NOUN
admet-184	96	18	is	be	AUX
admet-184	96	19	the	the	DET
admet-184	96	20	most	most	ADV
admet-184	96	21	plausible	plausible	ADJ
admet-184	96	22	mechanism	mechanism	NOUN
admet-184	96	23	[	[	X
admet-184	96	24	18	18	NUM
admet-184	96	25	]	]	PUNCT
admet-184	96	26	.	.	PUNCT
admet-184	97	1	is	be	AUX
admet-184	97	2	n2b	n2b	PROPN
admet-184	97	3	insulin	insulin	NOUN
admet-184	97	4	appropriate	appropriate	ADJ
admet-184	97	5	as	as	ADP
admet-184	97	6	therapy	therapy	NOUN
admet-184	97	7	for	for	ADP
admet-184	97	8	neurodegenerative	neurodegenerative	ADJ
admet-184	97	9	diseases	disease	NOUN
admet-184	97	10	?	?	PUNCT
admet-184	98	1	evidences	evidence	NOUN
admet-184	98	2	from	from	ADP
admet-184	98	3	in	in	ADP
admet-184	98	4	vivo	vivo	ADJ
admet-184	98	5	and	and	CCONJ
admet-184	98	6	clinical	clinical	ADJ
admet-184	98	7	studies	study	NOUN
admet-184	98	8	insulin	insulin	NOUN
admet-184	98	9	has	have	VERB
admet-184	98	10	a	a	DET
admet-184	98	11	molecular	molecular	ADJ
admet-184	98	12	weight	weight	NOUN
admet-184	98	13	of	of	ADP
admet-184	98	14	5.8	5.8	NUM
admet-184	98	15	kda	kda	NOUN
admet-184	98	16	and	and	CCONJ
admet-184	98	17	is	be	AUX
admet-184	98	18	one	one	NUM
admet-184	98	19	of	of	ADP
admet-184	98	20	the	the	DET
admet-184	98	21	oldest	old	ADJ
admet-184	98	22	recombinant	recombinant	ADJ
admet-184	98	23	biopharmaceuticals	biopharmaceutical	NOUN
admet-184	98	24	.	.	PUNCT
admet-184	99	1	insulin	insulin	NOUN
admet-184	99	2	has	have	VERB
admet-184	99	3	well	well	ADV
admet-184	99	4	-	-	PUNCT
admet-184	99	5	known	know	VERB
admet-184	99	6	peripheral	peripheral	ADJ
admet-184	99	7	metabolic	metabolic	NOUN
admet-184	99	8	effects	effect	NOUN
admet-184	99	9	and	and	CCONJ
admet-184	99	10	lowers	lower	VERB
admet-184	99	11	the	the	DET
admet-184	99	12	serum	serum	NOUN
admet-184	99	13	glucose	glucose	NOUN
admet-184	99	14	concentration	concentration	NOUN
admet-184	99	15	,	,	PUNCT
admet-184	99	16	but	but	CCONJ
admet-184	99	17	it	it	PRON
admet-184	99	18	also	also	ADV
admet-184	99	19	plays	play	VERB
admet-184	99	20	an	an	DET
admet-184	99	21	important	important	ADJ
admet-184	99	22	central	central	ADJ
admet-184	99	23	role	role	NOUN
admet-184	99	24	in	in	ADP
admet-184	99	25	cognition	cognition	NOUN
admet-184	99	26	,	,	PUNCT
admet-184	99	27	learning	learning	NOUN
admet-184	99	28	and	and	CCONJ
admet-184	99	29	memory	memory	NOUN
admet-184	100	1	[	[	X
admet-184	100	2	40	40	NUM
admet-184	100	3	-	-	SYM
admet-184	100	4	43	43	NUM
admet-184	100	5	]	]	PUNCT
admet-184	100	6	.	.	PUNCT
admet-184	101	1	furthermore	furthermore	ADV
admet-184	101	2	,	,	PUNCT
admet-184	101	3	dysregulation	dysregulation	NOUN
admet-184	101	4	of	of	ADP
admet-184	101	5	insulin	insulin	NOUN
admet-184	101	6	is	be	AUX
admet-184	101	7	involved	involve	VERB
admet-184	101	8	in	in	ADP
admet-184	101	9	the	the	DET
admet-184	101	10	pathogenesis	pathogenesis	NOUN
admet-184	101	11	of	of	ADP
admet-184	101	12	ad	ad	NOUN
admet-184	101	13	[	[	X
admet-184	101	14	44	44	NUM
admet-184	101	15	]	]	PUNCT
admet-184	101	16	.	.	PUNCT
admet-184	102	1	ad	ad	NOUN
admet-184	102	2	is	be	AUX
admet-184	102	3	associated	associate	VERB
admet-184	102	4	with	with	ADP
admet-184	102	5	lower	low	ADJ
admet-184	102	6	levels	level	NOUN
admet-184	102	7	of	of	ADP
admet-184	102	8	insulin	insulin	NOUN
admet-184	102	9	in	in	ADP
admet-184	102	10	the	the	DET
admet-184	102	11	csf	csf	NOUN
admet-184	102	12	and	and	CCONJ
admet-184	102	13	is	be	AUX
admet-184	102	14	involved	involve	VERB
admet-184	102	15	in	in	ADP
admet-184	102	16	amyloid	amyloid	NOUN
admet-184	102	17	-	-	PUNCT
admet-184	102	18	beta	beta	NOUN
admet-184	102	19	(	(	PUNCT
admet-184	102	20	a	a	NOUN
admet-184	102	21	)	)	PUNCT
admet-184	102	22	regulation	regulation	NOUN
admet-184	102	23	.	.	PUNCT
admet-184	103	1	in	in	ADP
admet-184	103	2	cellular	cellular	ADJ
admet-184	103	3	and	and	CCONJ
admet-184	103	4	animal	animal	NOUN
admet-184	103	5	ad	ad	NOUN
admet-184	103	6	models	model	NOUN
admet-184	103	7	,	,	PUNCT
admet-184	103	8	insulin	insulin	NOUN
admet-184	103	9	reduces	reduce	VERB
admet-184	103	10	aoligomer	aoligomer	NUM
admet-184	103	11	formation	formation	NOUN
admet-184	103	12	and	and	CCONJ
admet-184	103	13	protects	protect	VERB
admet-184	103	14	against	against	ADP
admet-184	103	15	a-toxicity	a-toxicity	NOUN
admet-184	103	16	[	[	X
admet-184	103	17	45	45	NUM
admet-184	103	18	]	]	PUNCT
admet-184	103	19	.	.	PUNCT
admet-184	104	1	in	in	ADP
admet-184	104	2	vitro	vitro	X
admet-184	104	3	studies	study	NOUN
admet-184	104	4	demonstrated	demonstrate	VERB
admet-184	104	5	that	that	SCONJ
admet-184	104	6	insulin	insulin	NOUN
admet-184	104	7	stimulates	stimulate	VERB
admet-184	104	8	the	the	DET
admet-184	104	9	formation	formation	NOUN
admet-184	104	10	of	of	ADP
admet-184	104	11	the	the	DET
admet-184	104	12	insulin	insulin	NOUN
admet-184	104	13	degrading	degrade	VERB
admet-184	104	14	enzyme	enzyme	NOUN
admet-184	104	15	(	(	PUNCT
admet-184	104	16	ide	ide	NOUN
admet-184	104	17	)	)	PUNCT
admet-184	104	18	,	,	PUNCT
admet-184	104	19	which	which	PRON
admet-184	104	20	is	be	AUX
admet-184	104	21	capable	capable	ADJ
admet-184	104	22	of	of	ADP
admet-184	104	23	degrading	degrade	VERB
admet-184	104	24	a	a	NOUN
admet-184	105	1	[	[	X
admet-184	105	2	46	46	NUM
admet-184	105	3	]	]	PUNCT
admet-184	105	4	.	.	PUNCT
admet-184	106	1	moreover	moreover	ADV
admet-184	106	2	,	,	PUNCT
admet-184	106	3	the	the	DET
admet-184	106	4	activity	activity	NOUN
admet-184	106	5	of	of	ADP
admet-184	106	6	glycogen	glycogen	NOUN
admet-184	106	7	-	-	PUNCT
admet-184	106	8	synthase	synthase	NOUN
admet-184	106	9	kinase-3	kinase-3	NOUN
admet-184	106	10	-	-	NOUN
admet-184	106	11	beta	beta	NOUN
admet-184	106	12	,	,	PUNCT
admet-184	106	13	a	a	DET
admet-184	106	14	tau	tau	PROPN
admet-184	106	15	kinase	kinase	NOUN
admet-184	106	16	associated	associate	VERB
admet-184	106	17	with	with	ADP
admet-184	106	18	the	the	DET
admet-184	106	19	formation	formation	NOUN
admet-184	106	20	of	of	ADP
admet-184	106	21	neurofibrillary	neurofibrillary	ADJ
admet-184	106	22	tangles	tangle	NOUN
admet-184	106	23	,	,	PUNCT
admet-184	106	24	has	have	AUX
admet-184	106	25	been	be	AUX
admet-184	106	26	reported	report	VERB
admet-184	106	27	to	to	PART
admet-184	106	28	be	be	AUX
admet-184	106	29	down	down	ADV
admet-184	106	30	-	-	PUNCT
admet-184	106	31	regulated	regulate	VERB
admet-184	106	32	in	in	ADP
admet-184	106	33	response	response	NOUN
admet-184	106	34	to	to	ADP
admet-184	106	35	insulin	insulin	NOUN
admet-184	106	36	[	[	X
admet-184	106	37	47	47	NUM
admet-184	106	38	]	]	PUNCT
admet-184	106	39	.	.	PUNCT
admet-184	107	1	post	post	PROPN
admet-184	107	2	mortem	mortem	X
admet-184	107	3	analyses	analysis	NOUN
admet-184	107	4	of	of	ADP
admet-184	107	5	human	human	ADJ
admet-184	107	6	ad	ad	NOUN
admet-184	107	7	brains	brain	NOUN
admet-184	107	8	have	have	AUX
admet-184	107	9	documented	document	VERB
admet-184	107	10	progressive	progressive	ADJ
admet-184	107	11	disruption	disruption	NOUN
admet-184	107	12	in	in	ADP
admet-184	107	13	central	central	ADJ
admet-184	107	14	insulin	insulin	NOUN
admet-184	107	15	regulation	regulation	NOUN
admet-184	107	16	.	.	PUNCT
admet-184	108	1	radioactive	radioactive	ADJ
admet-184	108	2	-	-	PUNCT
admet-184	108	3	labelled	label	VERB
admet-184	108	4	insulin	insulin	NOUN
admet-184	108	5	was	be	AUX
admet-184	108	6	distributed	distribute	VERB
admet-184	108	7	widely	widely	ADV
admet-184	108	8	throughout	throughout	ADP
admet-184	108	9	the	the	DET
admet-184	108	10	mouse	mouse	NOUN
admet-184	108	11	brain	brain	NOUN
admet-184	108	12	1	1	NUM
admet-184	108	13	h	h	NOUN
admet-184	108	14	following	follow	VERB
admet-184	108	15	intranasal	intranasal	ADJ
admet-184	108	16	administration	administration	NOUN
admet-184	108	17	,	,	PUNCT
admet-184	108	18	with	with	ADP
admet-184	108	19	the	the	DET
admet-184	108	20	highest	high	ADJ
admet-184	108	21	levels	level	NOUN
admet-184	108	22	detected	detect	VERB
admet-184	108	23	in	in	ADP
admet-184	108	24	the	the	DET
admet-184	108	25	trigeminal	trigeminal	ADJ
admet-184	108	26	nerve	nerve	NOUN
admet-184	108	27	and	and	CCONJ
admet-184	108	28	the	the	DET
admet-184	108	29	olfactory	olfactory	NOUN
admet-184	108	30	bulb	bulb	NOUN
admet-184	109	1	[	[	X
admet-184	109	2	43	43	NUM
admet-184	109	3	]	]	PUNCT
admet-184	109	4	.	.	PUNCT
admet-184	110	1	though	though	SCONJ
admet-184	110	2	insulin	insulin	NOUN
admet-184	110	3	undergoes	undergo	VERB
admet-184	110	4	transcytosis	transcytosis	NOUN
admet-184	110	5	at	at	ADP
admet-184	110	6	the	the	DET
admet-184	110	7	bbb	bbb	PROPN
admet-184	110	8	,	,	PUNCT
admet-184	110	9	intranasal	intranasal	ADJ
admet-184	110	10	administration	administration	NOUN
admet-184	110	11	reached	reach	VERB
admet-184	110	12	significantly	significantly	ADV
admet-184	110	13	higher	high	ADJ
admet-184	110	14	cns	cns	NOUN
admet-184	110	15	levels	level	NOUN
admet-184	110	16	when	when	SCONJ
admet-184	110	17	comparing	compare	VERB
admet-184	110	18	with	with	ADP
admet-184	110	19	subcutaneous	subcutaneous	ADJ
admet-184	110	20	administration	administration	NOUN
admet-184	110	21	at	at	ADP
admet-184	110	22	the	the	DET
admet-184	110	23	same	same	ADJ
admet-184	110	24	time	time	NOUN
admet-184	110	25	.	.	PUNCT
admet-184	111	1	intranasal	intranasal	ADJ
admet-184	111	2	insulin	insulin	NOUN
admet-184	111	3	also	also	ADV
admet-184	111	4	slowed	slow	VERB
admet-184	111	5	development	development	NOUN
admet-184	111	6	of	of	ADP
admet-184	111	7	cognitive	cognitive	ADJ
admet-184	111	8	decline	decline	NOUN
admet-184	111	9	in	in	ADP
admet-184	111	10	different	different	ADJ
admet-184	111	11	disease	disease	NOUN
admet-184	111	12	models	model	NOUN
admet-184	111	13	[	[	X
admet-184	111	14	43	43	NUM
admet-184	111	15	]	]	PUNCT
admet-184	111	16	and	and	CCONJ
admet-184	111	17	improved	improved	ADJ
admet-184	111	18	learning	learning	NOUN
admet-184	111	19	and	and	CCONJ
admet-184	111	20	memory	memory	NOUN
admet-184	111	21	in	in	ADP
admet-184	111	22	wild	wild	ADJ
admet-184	111	23	type	type	NOUN
admet-184	111	24	mice	mouse	NOUN
admet-184	111	25	[	[	X
admet-184	111	26	48	48	NUM
admet-184	111	27	]	]	PUNCT
admet-184	111	28	.	.	PUNCT
admet-184	112	1	very	very	ADV
admet-184	112	2	interestingly	interestingly	ADV
admet-184	112	3	,	,	PUNCT
admet-184	112	4	incretins	incretin	NOUN
admet-184	112	5	–	–	PUNCT
admet-184	112	6	a	a	DET
admet-184	112	7	group	group	NOUN
admet-184	112	8	of	of	ADP
admet-184	112	9	metabolic	metabolic	NOUN
admet-184	112	10	hormones	hormone	NOUN
admet-184	112	11	–	–	PUNCT
admet-184	112	12	favour	favour	VERB
admet-184	112	13	insulin	insulin	NOUN
admet-184	112	14	release	release	NOUN
admet-184	112	15	in	in	ADP
admet-184	112	16	the	the	DET
admet-184	112	17	periphery	periphery	NOUN
admet-184	112	18	and	and	CCONJ
admet-184	112	19	likewise	likewise	ADV
admet-184	112	20	they	they	PRON
admet-184	112	21	have	have	VERB
admet-184	112	22	a	a	DET
admet-184	112	23	comparable	comparable	ADJ
admet-184	112	24	central	central	ADJ
admet-184	112	25	activity	activity	NOUN
admet-184	112	26	as	as	ADP
admet-184	112	27	insulin	insulin	NOUN
admet-184	112	28	.	.	PUNCT
admet-184	113	1	exendin	exendin	VERB
admet-184	113	2	–	–	PUNCT
admet-184	113	3	an	an	DET
admet-184	113	4	agonist	agonist	NOUN
admet-184	113	5	at	at	ADP
admet-184	113	6	the	the	DET
admet-184	113	7	glp-1	glp-1	X
admet-184	113	8	(	(	PUNCT
admet-184	113	9	glucagon	glucagon	NOUN
admet-184	113	10	-	-	PUNCT
admet-184	113	11	like	like	ADJ
admet-184	113	12	peptide-1	peptide-1	NOUN
admet-184	113	13	)	)	PUNCT
admet-184	113	14	receptor	receptor	NOUN
admet-184	113	15	–	–	PUNCT
admet-184	113	16	improved	improve	VERB
admet-184	113	17	learning	learn	VERB
admet-184	114	1	[	[	X
admet-184	114	2	49	49	NUM
admet-184	114	3	]	]	PUNCT
admet-184	114	4	when	when	SCONJ
admet-184	114	5	delivered	deliver	VERB
admet-184	114	6	via	via	ADP
admet-184	114	7	n2b	n2b	PROPN
admet-184	114	8	.	.	PUNCT
admet-184	115	1	higher	high	ADJ
admet-184	115	2	brain	brain	NOUN
admet-184	115	3	levels	level	NOUN
admet-184	115	4	of	of	ADP
admet-184	115	5	exendin	exendin	NOUN
admet-184	115	6	were	be	AUX
admet-184	115	7	found	find	VERB
admet-184	115	8	after	after	ADP
admet-184	115	9	intranasal	intranasal	ADJ
admet-184	115	10	administration	administration	NOUN
admet-184	115	11	when	when	SCONJ
admet-184	115	12	compared	compare	VERB
admet-184	115	13	to	to	ADP
admet-184	115	14	intravenous	intravenous	ADJ
admet-184	115	15	injection	injection	NOUN
admet-184	115	16	[	[	X
admet-184	115	17	50	50	NUM
admet-184	115	18	]	]	PUNCT
admet-184	115	19	.	.	PUNCT
admet-184	116	1	clinical	clinical	ADJ
admet-184	116	2	trials	trial	NOUN
admet-184	116	3	with	with	ADP
admet-184	116	4	intranasal	intranasal	ADJ
admet-184	116	5	insulin	insulin	NOUN
admet-184	116	6	have	have	AUX
admet-184	116	7	provided	provide	VERB
admet-184	116	8	positive	positive	ADJ
admet-184	116	9	effects	effect	NOUN
admet-184	116	10	in	in	ADP
admet-184	116	11	small	small	ADJ
admet-184	116	12	cohorts	cohort	NOUN
admet-184	116	13	of	of	ADP
admet-184	116	14	ad	ad	NOUN
admet-184	116	15	patients	patient	NOUN
admet-184	116	16	and	and	CCONJ
admet-184	116	17	mild	mild	ADJ
admet-184	116	18	cognitive	cognitive	ADJ
admet-184	116	19	impairment	impairment	NOUN
admet-184	116	20	in	in	ADP
admet-184	116	21	verbal	verbal	ADJ
admet-184	116	22	,	,	PUNCT
admet-184	116	23	visospatial	visospatial	ADJ
admet-184	116	24	and	and	CCONJ
admet-184	116	25	episodic	episodic	ADJ
admet-184	116	26	memory	memory	NOUN
admet-184	116	27	[	[	X
admet-184	116	28	40,45,51	40,45,51	NOUN
admet-184	116	29	]	]	X
admet-184	116	30	.	.	PUNCT
admet-184	117	1	unfortunately	unfortunately	ADV
admet-184	117	2	,	,	PUNCT
admet-184	117	3	only	only	ADV
admet-184	117	4	one	one	NUM
admet-184	117	5	study	study	NOUN
admet-184	117	6	in	in	ADP
admet-184	117	7	humans	human	NOUN
admet-184	117	8	gives	give	VERB
admet-184	117	9	detailed	detailed	ADJ
admet-184	117	10	pk	pk	NOUN
admet-184	117	11	data	datum	NOUN
admet-184	117	12	(	(	PUNCT
admet-184	117	13	plasma	plasma	NOUN
admet-184	117	14	and	and	CCONJ
admet-184	117	15	csf	csf	NOUN
admet-184	117	16	)	)	PUNCT
admet-184	117	17	after	after	ADP
admet-184	117	18	n2b	n2b	PROPN
admet-184	117	19	delivery	delivery	NOUN
admet-184	117	20	of	of	ADP
admet-184	117	21	peptides	peptide	NOUN
admet-184	117	22	including	include	VERB
admet-184	117	23	insulin	insulin	NOUN
admet-184	117	24	[	[	X
admet-184	117	25	52	52	NUM
admet-184	117	26	]	]	PUNCT
admet-184	117	27	.	.	PUNCT
admet-184	118	1	interestingly	interestingly	ADV
admet-184	118	2	,	,	PUNCT
admet-184	118	3	the	the	DET
admet-184	118	4	plasma	plasma	NOUN
admet-184	118	5	levels	level	NOUN
admet-184	118	6	of	of	ADP
admet-184	118	7	insulin	insulin	NOUN
admet-184	118	8	have	have	AUX
admet-184	118	9	not	not	PART
admet-184	118	10	been	be	AUX
admet-184	118	11	altered	alter	VERB
admet-184	118	12	by	by	ADP
admet-184	118	13	intranasal	intranasal	ADJ
admet-184	118	14	administration	administration	NOUN
admet-184	118	15	of	of	ADP
admet-184	118	16	10	10	NUM
admet-184	118	17	iu	iu	ADP
admet-184	118	18	insulin	insulin	NOUN
admet-184	118	19	while	while	SCONJ
admet-184	118	20	a	a	DET
admet-184	118	21	clear	clear	ADJ
admet-184	118	22	peak	peak	NOUN
admet-184	118	23	in	in	ADP
admet-184	118	24	csf	csf	ADJ
admet-184	118	25	levels	level	NOUN
admet-184	118	26	was	be	AUX
admet-184	118	27	detectable	detectable	ADJ
admet-184	118	28	after	after	ADP
admet-184	118	29	30	30	NUM
admet-184	118	30	and	and	CCONJ
admet-184	118	31	80	80	NUM
admet-184	118	32	minutes	minute	NOUN
admet-184	118	33	.	.	PUNCT
admet-184	119	1	this	this	DET
admet-184	119	2	study	study	NOUN
admet-184	119	3	has	have	AUX
admet-184	119	4	been	be	AUX
admet-184	119	5	admet	admet	PROPN
admet-184	119	6	&	&	CCONJ
admet-184	119	7	dmpk	dmpk	PROPN
admet-184	119	8	3(3	3(3	NUM
admet-184	119	9	)	)	PUNCT
admet-184	119	10	(	(	PUNCT
admet-184	119	11	2015	2015	NUM
admet-184	119	12	)	)	PUNCT
admet-184	119	13	190	190	NUM
admet-184	119	14	-	-	SYM
admet-184	119	15	202	202	NUM
admet-184	119	16	intranasal	intranasal	ADJ
admet-184	119	17	insulin	insulin	NOUN
admet-184	119	18	as	as	ADP
admet-184	119	19	hope	hope	NOUN
admet-184	119	20	for	for	ADP
admet-184	119	21	ad	ad	NOUN
admet-184	119	22	?	?	PUNCT
admet-184	120	1	doi	doi	NOUN
admet-184	120	2	:	:	PUNCT
admet-184	120	3	10.5599	10.5599	NUM
admet-184	120	4	/	/	SYM
admet-184	120	5	admet.3.3.184	admet.3.3.184	SYM
admet-184	120	6	195	195	NUM
admet-184	120	7	conducted	conduct	VERB
admet-184	120	8	with	with	ADP
admet-184	120	9	a	a	DET
admet-184	120	10	conventional	conventional	ADJ
admet-184	120	11	nasal	nasal	NOUN
admet-184	120	12	spray	spray	NOUN
admet-184	120	13	atomizer	atomizer	NOUN
admet-184	120	14	filled	fill	VERB
admet-184	120	15	with	with	ADP
admet-184	120	16	insulin	insulin	NOUN
admet-184	120	17	formulated	formulate	VERB
admet-184	120	18	for	for	ADP
admet-184	120	19	subcutaneous	subcutaneous	ADJ
admet-184	120	20	delivery	delivery	NOUN
admet-184	120	21	.	.	PUNCT
admet-184	121	1	the	the	DET
admet-184	121	2	same	same	ADJ
admet-184	121	3	group	group	NOUN
admet-184	121	4	observed	observe	VERB
admet-184	121	5	that	that	SCONJ
admet-184	121	6	insulin	insulin	NOUN
admet-184	121	7	delivered	deliver	VERB
admet-184	121	8	intranasally	intranasally	ADV
admet-184	121	9	improved	improve	VERB
admet-184	121	10	memory	memory	NOUN
admet-184	121	11	and	and	CCONJ
admet-184	121	12	mood	mood	NOUN
admet-184	122	1	[	[	X
admet-184	122	2	40,53	40,53	NOUN
admet-184	122	3	]	]	PUNCT
admet-184	122	4	.	.	PUNCT
admet-184	123	1	in	in	ADP
admet-184	123	2	addition	addition	NOUN
admet-184	123	3	,	,	PUNCT
admet-184	123	4	n2b	n2b	PROPN
admet-184	123	5	delivered	deliver	VERB
admet-184	123	6	insulin	insulin	NOUN
admet-184	123	7	decreased	decrease	VERB
admet-184	123	8	food	food	NOUN
admet-184	123	9	intake	intake	NOUN
admet-184	123	10	and	and	CCONJ
admet-184	123	11	decreased	decrease	VERB
admet-184	123	12	postprandial	postprandial	ADJ
admet-184	123	13	serum	serum	NOUN
admet-184	123	14	insulin	insulin	NOUN
admet-184	123	15	[	[	X
admet-184	123	16	54,55	54,55	X
admet-184	123	17	]	]	PUNCT
admet-184	123	18	.	.	PUNCT
admet-184	124	1	in	in	ADP
admet-184	124	2	patients	patient	NOUN
admet-184	124	3	with	with	ADP
admet-184	124	4	amnesic	amnesic	ADJ
admet-184	124	5	mild	mild	ADJ
admet-184	124	6	cognitive	cognitive	ADJ
admet-184	124	7	impairment	impairment	NOUN
admet-184	124	8	the	the	DET
admet-184	124	9	treatment	treatment	NOUN
admet-184	124	10	modulated	modulate	VERB
admet-184	124	11	plasma	plasma	NOUN
admet-184	124	12	levels	level	NOUN
admet-184	124	13	of	of	ADP
admet-184	124	14	a	a	PROPN
admet-184	124	15	and	and	CCONJ
admet-184	124	16	improved	improved	ADJ
admet-184	124	17	memory	memory	NOUN
admet-184	124	18	,	,	PUNCT
admet-184	124	19	concluding	conclude	VERB
admet-184	124	20	intranasal	intranasal	ADJ
admet-184	124	21	delivery	delivery	NOUN
admet-184	124	22	of	of	ADP
admet-184	124	23	insulin	insulin	NOUN
admet-184	124	24	as	as	ADP
admet-184	124	25	a	a	DET
admet-184	124	26	possible	possible	ADJ
admet-184	124	27	treatment	treatment	NOUN
admet-184	124	28	for	for	ADP
admet-184	124	29	ad	ad	NOUN
admet-184	124	30	[	[	X
admet-184	124	31	56	56	NUM
admet-184	124	32	]	]	PUNCT
admet-184	124	33	.	.	PUNCT
admet-184	125	1	in	in	ADP
admet-184	125	2	ad	ad	NOUN
admet-184	125	3	patients	patient	NOUN
admet-184	125	4	a	a	DET
admet-184	125	5	chronic	chronic	ADJ
admet-184	125	6	treatment	treatment	NOUN
admet-184	125	7	over	over	ADP
admet-184	125	8	21	21	NUM
admet-184	125	9	days	day	NOUN
admet-184	125	10	with	with	ADP
admet-184	125	11	intranasal	intranasal	ADJ
admet-184	125	12	insulin	insulin	NOUN
admet-184	125	13	(	(	PUNCT
admet-184	125	14	20	20	NUM
admet-184	125	15	or	or	CCONJ
admet-184	125	16	40	40	NUM
admet-184	125	17	iu	iu	ADP
admet-184	125	18	novolin	novolin	PROPN
admet-184	125	19	r	r	PROPN
admet-184	125	20	)	)	PUNCT
admet-184	125	21	improved	improved	ADJ
admet-184	125	22	memory	memory	NOUN
admet-184	125	23	,	,	PUNCT
admet-184	125	24	attention	attention	NOUN
admet-184	125	25	and	and	CCONJ
admet-184	125	26	functioning	function	VERB
admet-184	125	27	[	[	X
admet-184	125	28	51	51	NUM
admet-184	125	29	]	]	PUNCT
admet-184	125	30	.	.	PUNCT
admet-184	126	1	in	in	ADP
admet-184	126	2	this	this	DET
admet-184	126	3	study	study	NOUN
admet-184	126	4	,	,	PUNCT
admet-184	126	5	patients	patient	NOUN
admet-184	126	6	were	be	AUX
admet-184	126	7	placed	place	VERB
admet-184	126	8	in	in	ADP
admet-184	126	9	a	a	DET
admet-184	126	10	supine	supine	ADJ
admet-184	126	11	position	position	NOUN
admet-184	126	12	with	with	ADP
admet-184	126	13	the	the	DET
admet-184	126	14	head	head	NOUN
admet-184	126	15	tilted	tilt	VERB
admet-184	126	16	back	back	ADV
admet-184	126	17	and	and	CCONJ
admet-184	126	18	insulin	insulin	NOUN
admet-184	126	19	or	or	CCONJ
admet-184	126	20	placebo	placebo	NOUN
admet-184	126	21	saline	saline	NOUN
admet-184	126	22	was	be	AUX
admet-184	126	23	administered	administer	VERB
admet-184	126	24	with	with	ADP
admet-184	126	25	a	a	DET
admet-184	126	26	needle	needle	NOUN
admet-184	126	27	-	-	PUNCT
admet-184	126	28	less	less	ADJ
admet-184	126	29	syringe	syringe	NOUN
admet-184	126	30	into	into	ADP
admet-184	126	31	alternating	alternate	VERB
admet-184	126	32	nostrils	nostril	NOUN
admet-184	126	33	with	with	ADP
admet-184	126	34	a	a	DET
admet-184	126	35	total	total	ADJ
admet-184	126	36	administration	administration	NOUN
admet-184	126	37	volume	volume	NOUN
admet-184	126	38	of	of	ADP
admet-184	126	39	400	400	NUM
admet-184	126	40	µl	µl	NOUN
admet-184	126	41	.	.	PUNCT
admet-184	127	1	a	a	DET
admet-184	127	2	validation	validation	NOUN
admet-184	127	3	of	of	ADP
admet-184	127	4	this	this	DET
admet-184	127	5	administration	administration	NOUN
admet-184	127	6	technique	technique	NOUN
admet-184	127	7	like	like	ADP
admet-184	127	8	the	the	DET
admet-184	127	9	group	group	NOUN
admet-184	127	10	of	of	ADP
admet-184	127	11	mori	mori	PROPN
admet-184	127	12	et	et	PROPN
admet-184	127	13	al	al	PROPN
admet-184	127	14	.	.	PROPN
admet-184	127	15	did	do	VERB
admet-184	128	1	[	[	X
admet-184	128	2	57	57	NUM
admet-184	128	3	]	]	PUNCT
admet-184	128	4	was	be	AUX
admet-184	128	5	not	not	PART
admet-184	128	6	presented	present	VERB
admet-184	128	7	.	.	PUNCT
admet-184	129	1	moreover	moreover	ADV
admet-184	129	2	,	,	PUNCT
admet-184	129	3	no	no	DET
admet-184	129	4	determination	determination	NOUN
admet-184	129	5	or	or	CCONJ
admet-184	129	6	estimation	estimation	NOUN
admet-184	129	7	of	of	ADP
admet-184	129	8	the	the	DET
admet-184	129	9	volume	volume	NOUN
admet-184	129	10	that	that	PRON
admet-184	129	11	reached	reach	VERB
admet-184	129	12	the	the	DET
admet-184	129	13	olfactory	olfactory	NOUN
admet-184	129	14	cleft	cleft	NOUN
admet-184	129	15	was	be	AUX
admet-184	129	16	published	publish	VERB
admet-184	129	17	.	.	PUNCT
admet-184	130	1	in	in	ADP
admet-184	130	2	addition	addition	NOUN
admet-184	130	3	,	,	PUNCT
admet-184	130	4	the	the	DET
admet-184	130	5	volume	volume	NOUN
admet-184	130	6	that	that	PRON
admet-184	130	7	was	be	AUX
admet-184	130	8	swallowed	swallow	VERB
admet-184	130	9	or	or	CCONJ
admet-184	130	10	aspirated	aspirate	VERB
admet-184	130	11	during	during	ADP
admet-184	130	12	the	the	DET
admet-184	130	13	procedure	procedure	NOUN
admet-184	130	14	was	be	AUX
admet-184	130	15	not	not	PART
admet-184	130	16	determined	determine	VERB
admet-184	130	17	.	.	PUNCT
admet-184	131	1	hence	hence	ADV
admet-184	131	2	,	,	PUNCT
admet-184	131	3	a	a	DET
admet-184	131	4	calculation	calculation	NOUN
admet-184	131	5	of	of	ADP
admet-184	131	6	the	the	DET
admet-184	131	7	central	central	ADJ
admet-184	131	8	bioavailability	bioavailability	NOUN
admet-184	131	9	e.g.	e.g.	ADV
admet-184	131	10	insulin	insulin	NOUN
admet-184	131	11	levels	level	NOUN
admet-184	131	12	in	in	ADP
admet-184	131	13	csf	csf	ADJ
admet-184	131	14	samples	sample	NOUN
admet-184	131	15	is	be	AUX
admet-184	131	16	due	due	ADJ
admet-184	131	17	to	to	ADP
admet-184	131	18	the	the	DET
admet-184	131	19	lack	lack	NOUN
admet-184	131	20	of	of	ADP
admet-184	131	21	data	datum	NOUN
admet-184	131	22	not	not	PART
admet-184	131	23	possible	possible	ADJ
admet-184	131	24	.	.	PUNCT
admet-184	132	1	the	the	DET
admet-184	132	2	serum	serum	NOUN
admet-184	132	3	levels	level	NOUN
admet-184	132	4	of	of	ADP
admet-184	132	5	insulin	insulin	NOUN
admet-184	132	6	and	and	CCONJ
admet-184	132	7	glucose	glucose	NOUN
admet-184	132	8	at	at	ADP
admet-184	132	9	baseline	baseline	NOUN
admet-184	132	10	and	and	CCONJ
admet-184	132	11	45	45	NUM
admet-184	132	12	minutes	minute	NOUN
admet-184	132	13	after	after	SCONJ
admet-184	132	14	administration	administration	NOUN
admet-184	132	15	are	be	AUX
admet-184	132	16	not	not	PART
admet-184	132	17	altered	alter	VERB
admet-184	132	18	,	,	PUNCT
admet-184	132	19	though	though	ADV
admet-184	132	20	,	,	PUNCT
admet-184	132	21	the	the	DET
admet-184	132	22	insulin	insulin	NOUN
admet-184	132	23	levels	level	NOUN
admet-184	132	24	in	in	ADP
admet-184	132	25	all	all	DET
admet-184	132	26	three	three	NUM
admet-184	132	27	arms	arm	NOUN
admet-184	132	28	were	be	AUX
admet-184	132	29	rather	rather	ADV
admet-184	132	30	high	high	ADJ
admet-184	132	31	for	for	ADP
admet-184	132	32	fasting	fast	VERB
admet-184	132	33	non	non	ADJ
admet-184	132	34	-	-	ADJ
admet-184	132	35	diabetic	diabetic	ADJ
admet-184	132	36	subjects	subject	NOUN
admet-184	132	37	.	.	PUNCT
admet-184	133	1	however	however	ADV
admet-184	133	2	,	,	PUNCT
admet-184	133	3	a	a	DET
admet-184	133	4	pk	pk	NOUN
admet-184	133	5	study	study	NOUN
admet-184	133	6	focusing	focus	VERB
admet-184	133	7	on	on	ADP
admet-184	133	8	the	the	DET
admet-184	133	9	administration	administration	NOUN
admet-184	133	10	of	of	ADP
admet-184	133	11	intranasal	intranasal	ADJ
admet-184	133	12	insulin	insulin	NOUN
admet-184	133	13	preparations	preparation	NOUN
admet-184	133	14	for	for	ADP
admet-184	133	15	the	the	DET
admet-184	133	16	treatment	treatment	NOUN
admet-184	133	17	of	of	ADP
admet-184	133	18	diabetes	diabetes	NOUN
admet-184	133	19	mellitus	mellitus	NOUN
admet-184	133	20	showed	show	VERB
admet-184	133	21	that	that	SCONJ
admet-184	133	22	the	the	DET
admet-184	133	23	serum	serum	NOUN
admet-184	133	24	insulin	insulin	NOUN
admet-184	133	25	levels	level	NOUN
admet-184	133	26	peaked	peak	VERB
admet-184	133	27	rapidly	rapidly	ADV
admet-184	133	28	after	after	ADP
admet-184	133	29	15	15	NUM
admet-184	133	30	minutes	minute	NOUN
admet-184	133	31	with	with	ADP
admet-184	133	32	25	25	NUM
admet-184	133	33	iu	iu	ADP
admet-184	133	34	insulin	insulin	NOUN
admet-184	133	35	and	and	CCONJ
admet-184	133	36	returned	return	VERB
admet-184	133	37	to	to	ADP
admet-184	133	38	the	the	DET
admet-184	133	39	baseline	baseline	NOUN
admet-184	133	40	after	after	ADP
admet-184	133	41	45	45	NUM
admet-184	133	42	minutes	minute	NOUN
admet-184	133	43	[	[	X
admet-184	133	44	58	58	NUM
admet-184	133	45	]	]	PUNCT
admet-184	133	46	.	.	PUNCT
admet-184	134	1	this	this	DET
admet-184	134	2	data	datum	NOUN
admet-184	134	3	were	be	AUX
admet-184	134	4	meanwhile	meanwhile	ADV
admet-184	134	5	confirmed	confirm	VERB
admet-184	134	6	without	without	ADP
admet-184	134	7	adsorption	adsorption	NOUN
admet-184	134	8	enhancer	enhancer	NOUN
admet-184	134	9	and	and	CCONJ
admet-184	134	10	160	160	NUM
admet-184	134	11	iu	iu	ADP
admet-184	134	12	intranasal	intranasal	ADJ
admet-184	134	13	insulin	insulin	NOUN
admet-184	134	14	with	with	ADP
admet-184	134	15	diabetic	diabetic	ADJ
admet-184	134	16	and	and	CCONJ
admet-184	134	17	control	control	NOUN
admet-184	134	18	subjects	subject	NOUN
admet-184	134	19	[	[	X
admet-184	134	20	59	59	NUM
admet-184	134	21	]	]	PUNCT
admet-184	134	22	.	.	PUNCT
admet-184	135	1	in	in	ADP
admet-184	135	2	addition	addition	NOUN
admet-184	135	3	,	,	PUNCT
admet-184	135	4	the	the	DET
admet-184	135	5	authors	author	NOUN
admet-184	135	6	specified	specify	VERB
admet-184	135	7	in	in	ADP
admet-184	135	8	the	the	DET
admet-184	135	9	procedure	procedure	NOUN
admet-184	135	10	that	that	PRON
admet-184	135	11	the	the	DET
admet-184	135	12	patients	patient	NOUN
admet-184	135	13	were	be	AUX
admet-184	135	14	fasting	fast	VERB
admet-184	135	15	at	at	ADP
admet-184	135	16	administration	administration	NOUN
admet-184	135	17	,	,	PUNCT
admet-184	135	18	but	but	CCONJ
admet-184	135	19	did	do	AUX
admet-184	135	20	not	not	PART
admet-184	135	21	specify	specify	VERB
admet-184	135	22	this	this	PRON
admet-184	135	23	for	for	ADP
admet-184	135	24	blood	blood	NOUN
admet-184	135	25	collection	collection	NOUN
admet-184	135	26	[	[	X
admet-184	135	27	60	60	NUM
admet-184	135	28	]	]	PUNCT
admet-184	135	29	.	.	PUNCT
admet-184	136	1	hence	hence	ADV
admet-184	136	2	,	,	PUNCT
admet-184	136	3	the	the	DET
admet-184	136	4	published	publish	VERB
admet-184	136	5	samples	sample	NOUN
admet-184	136	6	collected	collect	VERB
admet-184	136	7	in	in	ADP
admet-184	136	8	the	the	DET
admet-184	136	9	latter	latter	ADJ
admet-184	136	10	study	study	NOUN
admet-184	136	11	are	be	AUX
admet-184	136	12	insufficient	insufficient	ADJ
admet-184	136	13	for	for	ADP
admet-184	136	14	pk	pk	NOUN
admet-184	136	15	-	-	PUNCT
admet-184	136	16	pd	pd	NOUN
admet-184	136	17	estimation	estimation	NOUN
admet-184	136	18	.	.	PUNCT
admet-184	137	1	a	a	DET
admet-184	137	2	four	four	NUM
admet-184	137	3	-	-	PUNCT
admet-184	137	4	month	month	NOUN
admet-184	137	5	pilot	pilot	NOUN
admet-184	137	6	study	study	NOUN
admet-184	137	7	from	from	ADP
admet-184	137	8	the	the	DET
admet-184	137	9	same	same	ADJ
admet-184	137	10	group	group	NOUN
admet-184	137	11	around	around	ADP
admet-184	137	12	craft	craft	PROPN
admet-184	137	13	et	et	PROPN
admet-184	137	14	al	al	PROPN
admet-184	137	15	.	.	PROPN
admet-184	137	16	was	be	AUX
admet-184	137	17	designed	design	VERB
admet-184	137	18	with	with	ADP
admet-184	137	19	three	three	NUM
admet-184	137	20	arms	arm	NOUN
admet-184	137	21	delivering	deliver	VERB
admet-184	137	22	a	a	DET
admet-184	137	23	daily	daily	ADJ
admet-184	137	24	dose	dose	NOUN
admet-184	137	25	of	of	ADP
admet-184	137	26	20	20	NUM
admet-184	137	27	iu	iu	ADP
admet-184	137	28	or	or	CCONJ
admet-184	137	29	40	40	NUM
admet-184	137	30	iu	iu	ADV
admet-184	137	31	intranasal	intranasal	ADJ
admet-184	137	32	insulin	insulin	NOUN
admet-184	137	33	(	(	PUNCT
admet-184	137	34	novolin	novolin	PROPN
admet-184	137	35	r	r	NOUN
admet-184	137	36	)	)	PUNCT
admet-184	137	37	or	or	CCONJ
admet-184	137	38	placebo	placebo	NOUN
admet-184	137	39	twice	twice	DET
admet-184	137	40	a	a	DET
admet-184	137	41	day	day	NOUN
admet-184	137	42	with	with	ADP
admet-184	137	43	the	the	DET
admet-184	137	44	nasal	nasal	PROPN
admet-184	137	45	drug	drug	NOUN
admet-184	137	46	delivery	delivery	NOUN
admet-184	137	47	device	device	NOUN
admet-184	137	48	vianase	vianase	NOUN
admet-184	137	49	™	™	VERB
admet-184	137	50	[	[	X
admet-184	137	51	61	61	NUM
admet-184	137	52	]	]	PUNCT
admet-184	137	53	.	.	PUNCT
admet-184	138	1	the	the	DET
admet-184	138	2	20	20	NUM
admet-184	138	3	iu	iu	NOUN
admet-184	138	4	insulin	insulin	NOUN
admet-184	138	5	group	group	NOUN
admet-184	138	6	benefited	benefit	VERB
admet-184	138	7	from	from	ADP
admet-184	138	8	the	the	DET
admet-184	138	9	treatment	treatment	NOUN
admet-184	138	10	with	with	ADP
admet-184	138	11	improved	improved	ADJ
admet-184	138	12	delayed	delay	VERB
admet-184	138	13	memory	memory	NOUN
admet-184	138	14	and	and	CCONJ
admet-184	138	15	both	both	DET
admet-184	138	16	groups	group	NOUN
admet-184	138	17	profited	profit	VERB
admet-184	138	18	from	from	ADP
admet-184	138	19	improved	improve	VERB
admet-184	138	20	daily	daily	ADJ
admet-184	138	21	function	function	NOUN
admet-184	138	22	and	and	CCONJ
admet-184	138	23	cerebral	cerebral	ADJ
admet-184	138	24	metabolism	metabolism	NOUN
admet-184	138	25	determined	determine	VERB
admet-184	138	26	by	by	ADP
admet-184	138	27	fdg	fdg	PROPN
admet-184	138	28	-	-	PUNCT
admet-184	138	29	pet	pet	NOUN
admet-184	138	30	.	.	PUNCT
admet-184	139	1	no	no	DET
admet-184	139	2	changes	change	NOUN
admet-184	139	3	in	in	ADP
admet-184	139	4	insulin	insulin	NOUN
admet-184	139	5	csf	csf	ADJ
admet-184	139	6	levels	level	NOUN
admet-184	139	7	were	be	AUX
admet-184	139	8	observed	observe	VERB
admet-184	139	9	.	.	PUNCT
admet-184	140	1	again	again	ADV
admet-184	140	2	this	this	DET
admet-184	140	3	study	study	NOUN
admet-184	140	4	had	have	VERB
admet-184	140	5	several	several	ADJ
admet-184	140	6	limitations	limitation	NOUN
admet-184	140	7	that	that	PRON
admet-184	140	8	were	be	AUX
admet-184	140	9	discussed	discuss	VERB
admet-184	140	10	by	by	ADP
admet-184	140	11	the	the	DET
admet-184	140	12	authors	author	NOUN
admet-184	140	13	.	.	PUNCT
admet-184	141	1	the	the	DET
admet-184	141	2	csf	csf	PROPN
admet-184	141	3	and	and	CCONJ
admet-184	141	4	fdg	fdg	PROPN
admet-184	141	5	-	-	ADJ
admet-184	141	6	pet	pet	ADJ
admet-184	141	7	data	datum	NOUN
admet-184	141	8	were	be	AUX
admet-184	141	9	collected	collect	VERB
admet-184	141	10	for	for	ADP
admet-184	141	11	only	only	ADV
admet-184	141	12	a	a	DET
admet-184	141	13	subset	subset	NOUN
admet-184	141	14	of	of	ADP
admet-184	141	15	participants	participant	NOUN
admet-184	141	16	.	.	PUNCT
admet-184	142	1	insulin	insulin	NOUN
admet-184	142	2	levels	level	NOUN
admet-184	142	3	in	in	ADP
admet-184	142	4	csf	csf	ADJ
admet-184	142	5	were	be	AUX
admet-184	142	6	not	not	PART
admet-184	142	7	collected	collect	VERB
admet-184	142	8	directly	directly	ADV
admet-184	142	9	after	after	ADP
admet-184	142	10	insulin	insulin	NOUN
admet-184	142	11	administration	administration	NOUN
admet-184	142	12	,	,	PUNCT
admet-184	142	13	though	though	SCONJ
admet-184	142	14	it	it	PRON
admet-184	142	15	is	be	AUX
admet-184	142	16	known	know	VERB
admet-184	142	17	that	that	SCONJ
admet-184	142	18	they	they	PRON
admet-184	142	19	drop	drop	VERB
admet-184	142	20	to	to	PART
admet-184	142	21	baseline	baseline	VERB
admet-184	142	22	within	within	ADP
admet-184	142	23	1	1	NUM
admet-184	142	24	hour	hour	NOUN
admet-184	142	25	after	after	ADP
admet-184	142	26	administration	administration	NOUN
admet-184	142	27	[	[	X
admet-184	142	28	52	52	NUM
admet-184	142	29	]	]	PUNCT
admet-184	142	30	.	.	PUNCT
admet-184	143	1	compared	compare	VERB
admet-184	143	2	to	to	ADP
admet-184	143	3	placebo	placebo	NOUN
admet-184	143	4	,	,	PUNCT
admet-184	143	5	more	more	ADJ
admet-184	143	6	patients	patient	NOUN
admet-184	143	7	suffered	suffer	VERB
admet-184	143	8	from	from	ADP
admet-184	143	9	nose	nose	NOUN
admet-184	143	10	bleeds	bleed	NOUN
admet-184	143	11	in	in	ADP
admet-184	143	12	the	the	DET
admet-184	143	13	verum	verum	PROPN
admet-184	143	14	group	group	NOUN
admet-184	143	15	.	.	PUNCT
admet-184	144	1	a	a	DET
admet-184	144	2	recently	recently	ADV
admet-184	144	3	published	publish	VERB
admet-184	144	4	study	study	NOUN
admet-184	144	5	used	use	VERB
admet-184	144	6	the	the	DET
admet-184	144	7	long	long	ADV
admet-184	144	8	-	-	PUNCT
admet-184	144	9	acting	act	VERB
admet-184	144	10	insulin	insulin	NOUN
admet-184	144	11	(	(	PUNCT
admet-184	144	12	detemir	detemir	PROPN
admet-184	144	13	,	,	PUNCT
admet-184	144	14	levemir	levemir	PROPN
admet-184	144	15	®	®	PROPN
admet-184	144	16	)	)	PUNCT
admet-184	144	17	delivered	deliver	VERB
admet-184	144	18	intranasally	intranasally	ADV
admet-184	144	19	via	via	ADP
admet-184	144	20	the	the	DET
admet-184	144	21	vianase	vianase	NOUN
admet-184	144	22	™	™	ADJ
admet-184	144	23	device	device	NOUN
admet-184	144	24	twice	twice	ADV
admet-184	144	25	daily	daily	ADV
admet-184	144	26	over	over	ADP
admet-184	144	27	21	21	NUM
admet-184	144	28	days	day	NOUN
admet-184	144	29	in	in	ADP
admet-184	144	30	ad	ad	NOUN
admet-184	144	31	patients	patient	NOUN
admet-184	144	32	[	[	X
admet-184	144	33	62	62	NUM
admet-184	144	34	]	]	PUNCT
admet-184	144	35	.	.	PUNCT
admet-184	145	1	detemir	detemir	PROPN
admet-184	145	2	binds	bind	VERB
admet-184	145	3	to	to	ADP
admet-184	145	4	albumin	albumin	NOUN
admet-184	145	5	resulting	result	VERB
admet-184	145	6	in	in	ADP
admet-184	145	7	a	a	DET
admet-184	145	8	prolonged	prolonged	ADJ
admet-184	145	9	release	release	NOUN
admet-184	145	10	and	and	CCONJ
admet-184	145	11	greater	great	ADJ
admet-184	145	12	parenchymal	parenchymal	ADJ
admet-184	145	13	penetration	penetration	NOUN
admet-184	145	14	.	.	PUNCT
admet-184	146	1	however	however	ADV
admet-184	146	2	,	,	PUNCT
admet-184	146	3	peripheral	peripheral	ADJ
admet-184	146	4	administered	administer	VERB
admet-184	146	5	detemir	detemir	NOUN
admet-184	146	6	is	be	AUX
admet-184	146	7	not	not	PART
admet-184	146	8	transported	transport	VERB
admet-184	146	9	across	across	ADP
admet-184	146	10	the	the	DET
admet-184	146	11	bbb	bbb	NOUN
admet-184	146	12	to	to	ADP
admet-184	146	13	the	the	DET
admet-184	146	14	brain	brain	NOUN
admet-184	146	15	[	[	X
admet-184	146	16	63	63	NUM
admet-184	146	17	]	]	PUNCT
admet-184	146	18	.	.	PUNCT
admet-184	147	1	here	here	ADV
admet-184	147	2	,	,	PUNCT
admet-184	147	3	the	the	DET
admet-184	147	4	40	40	NUM
admet-184	147	5	iu	iu	NOUN
admet-184	147	6	group	group	NOUN
admet-184	147	7	had	have	VERB
admet-184	147	8	the	the	DET
admet-184	147	9	largest	large	ADJ
admet-184	147	10	benefit	benefit	NOUN
admet-184	147	11	for	for	ADP
admet-184	147	12	the	the	DET
admet-184	147	13	memory	memory	NOUN
admet-184	147	14	composite	composite	NOUN
admet-184	147	15	compared	compare	VERB
admet-184	147	16	with	with	ADP
admet-184	147	17	placebo	placebo	NOUN
admet-184	147	18	.	.	PUNCT
admet-184	148	1	the	the	DET
admet-184	148	2	effect	effect	NOUN
admet-184	148	3	was	be	AUX
admet-184	148	4	significantly	significantly	ADV
admet-184	148	5	modulated	modulate	VERB
admet-184	148	6	by	by	ADP
admet-184	148	7	apoe4	apoe4	PROPN
admet-184	148	8	carriage	carriage	NOUN
admet-184	148	9	a	a	DET
admet-184	148	10	genetic	genetic	ADJ
admet-184	148	11	risk	risk	NOUN
admet-184	148	12	factor	factor	NOUN
admet-184	148	13	for	for	ADP
admet-184	148	14	ad	ad	NOUN
admet-184	148	15	,	,	PUNCT
admet-184	148	16	but	but	CCONJ
admet-184	148	17	also	also	ADV
admet-184	148	18	metabolic	metabolic	NOUN
admet-184	148	19	diseases	disease	NOUN
admet-184	148	20	and	and	CCONJ
admet-184	148	21	baseline	baseline	ADJ
admet-184	148	22	insulin	insulin	NOUN
admet-184	148	23	resistance	resistance	NOUN
admet-184	148	24	,	,	PUNCT
admet-184	148	25	both	both	PRON
admet-184	148	26	being	be	AUX
admet-184	148	27	associated	associate	VERB
admet-184	148	28	with	with	ADP
admet-184	148	29	higher	high	ADJ
admet-184	148	30	baseline	baseline	NOUN
admet-184	148	31	insulin	insulin	NOUN
admet-184	148	32	auc	auc	NOUN
admet-184	148	33	(	(	PUNCT
admet-184	148	34	area	area	NOUN
admet-184	148	35	under	under	ADP
admet-184	148	36	the	the	DET
admet-184	148	37	curve	curve	NOUN
admet-184	148	38	)	)	PUNCT
admet-184	148	39	.	.	PUNCT
admet-184	149	1	apoe4	apoe4	ADJ
admet-184	149	2	negative	negative	ADJ
admet-184	149	3	patients	patient	NOUN
admet-184	149	4	showed	show	VERB
admet-184	149	5	an	an	DET
admet-184	149	6	increased	increase	VERB
admet-184	149	7	insulin	insulin	NOUN
admet-184	149	8	resistance	resistance	NOUN
admet-184	149	9	after	after	ADP
admet-184	149	10	21	21	NUM
admet-184	149	11	days	day	NOUN
admet-184	149	12	treatment	treatment	NOUN
admet-184	149	13	with	with	ADP
admet-184	149	14	40	40	NUM
admet-184	149	15	iu	iu	ADP
admet-184	149	16	insulin	insulin	NOUN
admet-184	149	17	detemir	detemir	NOUN
admet-184	149	18	.	.	PUNCT
admet-184	150	1	no	no	DET
admet-184	150	2	effects	effect	NOUN
admet-184	150	3	were	be	AUX
admet-184	150	4	reported	report	VERB
admet-184	150	5	for	for	ADP
admet-184	150	6	daily	daily	ADJ
admet-184	150	7	or	or	CCONJ
admet-184	150	8	executive	executive	ADJ
admet-184	150	9	functioning	functioning	NOUN
admet-184	150	10	.	.	PUNCT
admet-184	151	1	two	two	NUM
admet-184	151	2	recent	recent	ADJ
admet-184	151	3	proof	proof	NOUN
admet-184	151	4	-	-	PUNCT
admet-184	151	5	of	of	ADP
admet-184	151	6	-	-	PUNCT
admet-184	151	7	concept	concept	NOUN
admet-184	151	8	studies	study	NOUN
admet-184	151	9	evaluated	evaluate	VERB
admet-184	151	10	the	the	DET
admet-184	151	11	acute	acute	ADJ
admet-184	151	12	effects	effect	NOUN
admet-184	151	13	on	on	ADP
admet-184	151	14	cerebral	cerebral	ADJ
admet-184	151	15	vasoreactivity	vasoreactivity	NOUN
admet-184	151	16	and	and	CCONJ
admet-184	151	17	cognition	cognition	NOUN
admet-184	151	18	of	of	ADP
admet-184	151	19	a	a	DET
admet-184	151	20	single	single	ADJ
admet-184	151	21	40	40	NUM
admet-184	151	22	iu	iu	ADP
admet-184	151	23	dose	dose	VERB
admet-184	151	24	of	of	ADP
admet-184	151	25	intranasal	intranasal	ADJ
admet-184	151	26	insulin	insulin	NOUN
admet-184	151	27	(	(	PUNCT
admet-184	151	28	novolin	novolin	PROPN
admet-184	151	29	®	®	PROPN
admet-184	151	30	)	)	PUNCT
admet-184	151	31	via	via	ADP
admet-184	151	32	a	a	DET
admet-184	151	33	vianase	vianase	NOUN
admet-184	151	34	™	™	ADJ
admet-184	151	35	device	device	NOUN
admet-184	151	36	compared	compare	VERB
admet-184	151	37	with	with	ADP
admet-184	151	38	placebo	placebo	NOUN
admet-184	151	39	in	in	ADP
admet-184	151	40	type	type	NOUN
admet-184	151	41	2	2	NUM
admet-184	151	42	diabetes	diabetes	NOUN
admet-184	151	43	(	(	PUNCT
admet-184	151	44	t2	t2	NOUN
admet-184	151	45	dm	dm	NOUN
admet-184	151	46	;	;	PUNCT
admet-184	151	47	[	[	X
admet-184	151	48	64,65	64,65	NOUN
admet-184	151	49	]	]	PUNCT
admet-184	151	50	)	)	PUNCT
admet-184	151	51	.	.	PUNCT
admet-184	152	1	across	across	ADP
admet-184	152	2	all	all	DET
admet-184	152	3	subjects	subject	NOUN
admet-184	152	4	,	,	PUNCT
admet-184	152	5	intranasal	intranasal	ADJ
admet-184	152	6	insulin	insulin	NOUN
admet-184	152	7	administered	administer	VERB
admet-184	152	8	improved	improve	VERB
admet-184	152	9	visuospatial	visuospatial	ADJ
admet-184	152	10	memory	memory	NOUN
admet-184	152	11	and	and	CCONJ
admet-184	152	12	increased	increase	VERB
admet-184	152	13	resting	rest	VERB
admet-184	152	14	-	-	PUNCT
admet-184	152	15	state	state	NOUN
admet-184	152	16	functional	functional	ADJ
admet-184	152	17	connectivity	connectivity	NOUN
admet-184	152	18	in	in	ADP
admet-184	152	19	older	old	ADJ
admet-184	152	20	adults	adult	NOUN
admet-184	152	21	with	with	ADP
admet-184	152	22	t2	t2	PROPN
admet-184	152	23	dm	dm	PROPN
admet-184	152	24	.	.	PUNCT
admet-184	152	25	m.	m.	NOUN
admet-184	152	26	stützle	stützle	NOUN
admet-184	152	27	,	,	PUNCT
admet-184	152	28	j.	j.	PROPN
admet-184	152	29	flamm	flamm	PROPN
admet-184	152	30	,	,	PUNCT
admet-184	152	31	s.	s.	PROPN
admet-184	152	32	carle	carle	PROPN
admet-184	152	33	and	and	CCONJ
admet-184	152	34	k.	k.	PROPN
admet-184	152	35	schindowski	schindowski	PROPN
admet-184	152	36	admet	admet	PROPN
admet-184	152	37	&	&	CCONJ
admet-184	152	38	dmpk	dmpk	PROPN
admet-184	152	39	3(3	3(3	NUM
admet-184	152	40	)	)	PUNCT
admet-184	152	41	(	(	PUNCT
admet-184	152	42	2015	2015	NUM
admet-184	152	43	)	)	PUNCT
admet-184	152	44	190	190	NUM
admet-184	152	45	-	-	SYM
admet-184	152	46	202	202	NUM
admet-184	152	47	196	196	NUM
admet-184	152	48	furthermore	furthermore	ADV
admet-184	152	49	,	,	PUNCT
admet-184	152	50	intranasal	intranasal	ADJ
admet-184	152	51	insulin	insulin	NOUN
admet-184	152	52	administration	administration	NOUN
admet-184	152	53	was	be	AUX
admet-184	152	54	well	well	ADV
admet-184	152	55	tolerated	tolerate	VERB
admet-184	152	56	.	.	PUNCT
admet-184	153	1	systemic	systemic	ADJ
admet-184	153	2	glucose	glucose	NOUN
admet-184	153	3	levels	level	NOUN
admet-184	153	4	were	be	AUX
admet-184	153	5	not	not	PART
admet-184	153	6	significantly	significantly	ADV
admet-184	153	7	altered	alter	VERB
admet-184	153	8	,	,	PUNCT
admet-184	153	9	though	though	SCONJ
admet-184	153	10	a	a	DET
admet-184	153	11	tendency	tendency	NOUN
admet-184	153	12	towards	towards	ADP
admet-184	153	13	decreased	decrease	VERB
admet-184	153	14	levels	level	NOUN
admet-184	153	15	was	be	AUX
admet-184	153	16	evident	evident	ADJ
admet-184	153	17	in	in	ADP
admet-184	153	18	diabetic	diabetic	ADJ
admet-184	153	19	individuals	individual	NOUN
admet-184	153	20	.	.	PUNCT
admet-184	154	1	heni	heni	PROPN
admet-184	154	2	et	et	PROPN
admet-184	154	3	al	al	PROPN
admet-184	154	4	.	.	PROPN
admet-184	154	5	reported	report	VERB
admet-184	154	6	improved	improve	VERB
admet-184	154	7	peripheral	peripheral	ADJ
admet-184	154	8	insulin	insulin	NOUN
admet-184	154	9	sensitivity	sensitivity	NOUN
admet-184	154	10	via	via	ADP
admet-184	154	11	hypothalamus	hypothalamus	NOUN
admet-184	154	12	and	and	CCONJ
admet-184	154	13	parasympathetic	parasympathetic	ADJ
admet-184	154	14	outputs	output	NOUN
admet-184	154	15	after	after	ADP
admet-184	154	16	160	160	NUM
admet-184	154	17	iu	iu	ADP
admet-184	154	18	insulin	insulin	NOUN
admet-184	154	19	dosed	dose	VERB
admet-184	154	20	with	with	ADP
admet-184	154	21	a	a	DET
admet-184	154	22	nasal	nasal	ADJ
admet-184	154	23	pump	pump	NOUN
admet-184	154	24	spray	spray	NOUN
admet-184	154	25	without	without	ADP
admet-184	154	26	absorption	absorption	NOUN
admet-184	154	27	enhancer	enhancer	NOUN
admet-184	154	28	[	[	X
admet-184	154	29	66	66	NUM
admet-184	154	30	]	]	PUNCT
admet-184	154	31	.	.	PUNCT
admet-184	155	1	the	the	DET
admet-184	155	2	investigators	investigator	NOUN
admet-184	155	3	used	use	VERB
admet-184	155	4	a	a	DET
admet-184	155	5	hyperinsulinemic	hyperinsulinemic	ADJ
admet-184	155	6	-	-	PUNCT
admet-184	155	7	euglycemic	euglycemic	ADJ
admet-184	155	8	glucose	glucose	NOUN
admet-184	155	9	clamp	clamp	NOUN
admet-184	155	10	with	with	ADP
admet-184	155	11	an	an	DET
admet-184	155	12	intravenous	intravenous	ADJ
admet-184	155	13	bolus	bolus	ADJ
admet-184	155	14	injection	injection	NOUN
admet-184	155	15	of	of	ADP
admet-184	155	16	6.25	6.25	NUM
admet-184	155	17	mu	mu	NOUN
admet-184	155	18	/	/	SYM
admet-184	155	19	kg	kg	PROPN
admet-184	155	20	insulin	insulin	NOUN
admet-184	155	21	90	90	NUM
admet-184	155	22	minutes	minute	NOUN
admet-184	155	23	prior	prior	ADV
admet-184	155	24	to	to	ADP
admet-184	155	25	intranasal	intranasal	ADJ
admet-184	155	26	administration	administration	NOUN
admet-184	155	27	and	and	CCONJ
admet-184	155	28	a	a	DET
admet-184	155	29	continuous	continuous	ADJ
admet-184	155	30	intravenous	intravenous	ADJ
admet-184	155	31	infusion	infusion	NOUN
admet-184	155	32	of	of	ADP
admet-184	155	33	0.25	0.25	NUM
admet-184	155	34	mu	mu	NOUN
admet-184	155	35	/	/	SYM
admet-184	155	36	kg	kg	PROPN
admet-184	155	37	/	/	SYM
admet-184	155	38	min	min	NOUN
admet-184	155	39	over	over	ADP
admet-184	155	40	210	210	NUM
admet-184	155	41	minutes	minute	NOUN
admet-184	155	42	.	.	PUNCT
admet-184	156	1	even	even	ADV
admet-184	156	2	under	under	ADP
admet-184	156	3	this	this	DET
admet-184	156	4	conditions	condition	NOUN
admet-184	156	5	plasma	plasma	NOUN
admet-184	156	6	insulin	insulin	NOUN
admet-184	156	7	peaked	peak	VERB
admet-184	156	8	after	after	ADP
admet-184	156	9	15	15	NUM
admet-184	156	10	minutes	minute	NOUN
admet-184	156	11	compared	compare	VERB
admet-184	156	12	to	to	ADP
admet-184	156	13	placebo	placebo	NOUN
admet-184	156	14	.	.	PUNCT
admet-184	157	1	the	the	DET
admet-184	157	2	glucose	glucose	NOUN
admet-184	157	3	consumption	consumption	NOUN
admet-184	157	4	needed	need	VERB
admet-184	157	5	to	to	PART
admet-184	157	6	keep	keep	VERB
admet-184	157	7	the	the	DET
admet-184	157	8	serum	serum	NOUN
admet-184	157	9	glucose	glucose	NOUN
admet-184	157	10	euglycaemic	euglycaemic	NOUN
admet-184	157	11	was	be	AUX
admet-184	157	12	significantly	significantly	ADV
admet-184	157	13	higher	high	ADJ
admet-184	157	14	in	in	ADP
admet-184	157	15	the	the	DET
admet-184	157	16	intranasal	intranasal	ADJ
admet-184	157	17	insulin	insulin	NOUN
admet-184	157	18	group	group	NOUN
admet-184	157	19	.	.	PUNCT
admet-184	158	1	the	the	DET
admet-184	158	2	authors	author	NOUN
admet-184	158	3	discuss	discuss	VERB
admet-184	158	4	the	the	DET
admet-184	158	5	use	use	NOUN
admet-184	158	6	of	of	ADP
admet-184	158	7	n2b	n2b	PROPN
admet-184	158	8	insulin	insulin	NOUN
admet-184	158	9	for	for	ADP
admet-184	158	10	central	central	ADJ
admet-184	158	11	insulin	insulin	NOUN
admet-184	158	12	resistance	resistance	NOUN
admet-184	158	13	in	in	ADP
admet-184	158	14	obesity	obesity	NOUN
admet-184	158	15	;	;	PUNCT
admet-184	158	16	ad	ad	NOUN
admet-184	158	17	is	be	AUX
admet-184	158	18	also	also	ADV
admet-184	158	19	associated	associate	VERB
admet-184	158	20	with	with	ADP
admet-184	158	21	impaired	impaired	ADJ
admet-184	158	22	central	central	ADJ
admet-184	158	23	insulin	insulin	NOUN
admet-184	158	24	resistance	resistance	NOUN
admet-184	158	25	.	.	PUNCT
admet-184	159	1	one	one	NUM
admet-184	159	2	study	study	NOUN
admet-184	159	3	with	with	ADP
admet-184	159	4	20	20	NUM
admet-184	159	5	iu	iu	NOUN
admet-184	159	6	could	could	AUX
admet-184	159	7	not	not	PART
admet-184	159	8	resolve	resolve	VERB
admet-184	159	9	any	any	DET
admet-184	159	10	significant	significant	ADJ
admet-184	159	11	effect	effect	NOUN
admet-184	159	12	either	either	CCONJ
admet-184	159	13	on	on	ADP
admet-184	159	14	cerebral	cerebral	ADJ
admet-184	159	15	glutamate	glutamate	ADJ
admet-184	159	16	concentration	concentration	NOUN
admet-184	159	17	and	and	CCONJ
admet-184	159	18	on	on	ADP
admet-184	159	19	memory	memory	NOUN
admet-184	159	20	[	[	X
admet-184	159	21	67	67	NUM
admet-184	159	22	]	]	PUNCT
admet-184	159	23	.	.	PUNCT
admet-184	160	1	several	several	ADJ
admet-184	160	2	other	other	ADJ
admet-184	160	3	unpublished	unpublished	ADJ
admet-184	160	4	studies	study	NOUN
admet-184	160	5	are	be	AUX
admet-184	160	6	summarized	summarize	VERB
admet-184	160	7	in	in	ADP
admet-184	160	8	table	table	NOUN
admet-184	160	9	1	1	NUM
admet-184	160	10	.	.	PUNCT
admet-184	161	1	according	accord	VERB
admet-184	161	2	to	to	ADP
admet-184	161	3	the	the	DET
admet-184	161	4	published	publish	VERB
admet-184	161	5	studies	study	NOUN
admet-184	161	6	,	,	PUNCT
admet-184	161	7	intranasal	intranasal	ADJ
admet-184	161	8	insulin	insulin	NOUN
admet-184	161	9	administration	administration	NOUN
admet-184	161	10	generally	generally	ADV
admet-184	161	11	neither	neither	CCONJ
admet-184	161	12	causes	cause	VERB
admet-184	161	13	nasal	nasal	ADJ
admet-184	161	14	irritation	irritation	NOUN
admet-184	161	15	nor	nor	CCONJ
admet-184	161	16	destroys	destroy	VERB
admet-184	161	17	the	the	DET
admet-184	161	18	olfactory	olfactory	NOUN
admet-184	161	19	function	function	NOUN
admet-184	161	20	and	and	CCONJ
admet-184	161	21	projections	projection	NOUN
admet-184	161	22	[	[	X
admet-184	161	23	48,68	48,68	X
admet-184	161	24	]	]	X
admet-184	161	25	.	.	PUNCT
admet-184	162	1	though	though	ADV
admet-184	162	2	,	,	PUNCT
admet-184	162	3	no	no	DET
admet-184	162	4	statistically	statistically	ADV
admet-184	162	5	significant	significant	ADJ
admet-184	162	6	effects	effect	NOUN
admet-184	162	7	on	on	ADP
admet-184	162	8	lipid	lipid	ADJ
admet-184	162	9	metabolism	metabolism	NOUN
admet-184	162	10	were	be	AUX
admet-184	162	11	observed	observe	VERB
admet-184	162	12	in	in	ADP
admet-184	162	13	the	the	DET
admet-184	162	14	3	3	NUM
admet-184	162	15	-	-	PUNCT
admet-184	162	16	week	week	NOUN
admet-184	162	17	detemir	detemir	NOUN
admet-184	162	18	-	-	NOUN
admet-184	162	19	study	study	NOUN
admet-184	162	20	,	,	PUNCT
admet-184	162	21	the	the	DET
admet-184	162	22	supplementary	supplementary	ADJ
admet-184	162	23	data	datum	NOUN
admet-184	162	24	of	of	ADP
admet-184	162	25	the	the	DET
admet-184	162	26	study	study	NOUN
admet-184	162	27	implicates	implicate	VERB
admet-184	162	28	a	a	DET
admet-184	162	29	dose	dose	NOUN
admet-184	162	30	-	-	PUNCT
admet-184	162	31	dependent	dependent	ADJ
admet-184	162	32	tendency	tendency	NOUN
admet-184	162	33	associating	associate	VERB
admet-184	162	34	insulin	insulin	NOUN
admet-184	162	35	treatment	treatment	NOUN
admet-184	162	36	with	with	ADP
admet-184	162	37	higher	high	ADJ
admet-184	162	38	total	total	ADJ
admet-184	162	39	cholesterol	cholesterol	NOUN
admet-184	162	40	,	,	PUNCT
admet-184	162	41	ldl	ldl	NOUN
admet-184	162	42	and	and	CCONJ
admet-184	162	43	lower	low	ADJ
admet-184	162	44	hdl	hdl	PROPN
admet-184	162	45	levels	level	NOUN
admet-184	162	46	.	.	PUNCT
admet-184	163	1	no	no	DET
admet-184	163	2	critical	critical	ADJ
admet-184	163	3	discussion	discussion	NOUN
admet-184	163	4	was	be	AUX
admet-184	163	5	found	find	VERB
admet-184	163	6	in	in	ADP
admet-184	163	7	any	any	DET
admet-184	163	8	study	study	NOUN
admet-184	163	9	,	,	PUNCT
admet-184	163	10	asking	ask	VERB
admet-184	163	11	about	about	ADP
admet-184	163	12	the	the	DET
admet-184	163	13	long	long	ADJ
admet-184	163	14	-	-	PUNCT
admet-184	163	15	term	term	NOUN
admet-184	163	16	mutagenic	mutagenic	ADJ
admet-184	163	17	effect	effect	NOUN
admet-184	163	18	of	of	ADP
admet-184	163	19	the	the	DET
admet-184	163	20	growth	growth	NOUN
admet-184	163	21	factor	factor	NOUN
admet-184	163	22	insulin	insulin	NOUN
admet-184	163	23	that	that	PRON
admet-184	163	24	is	be	AUX
admet-184	163	25	highly	highly	ADV
admet-184	163	26	associated	associate	VERB
admet-184	163	27	with	with	ADP
admet-184	163	28	increased	increase	VERB
admet-184	163	29	risk	risk	NOUN
admet-184	163	30	of	of	ADP
admet-184	163	31	cancer	cancer	NOUN
admet-184	163	32	.	.	PUNCT
admet-184	164	1	table	table	NOUN
admet-184	164	2	1	1	NUM
admet-184	164	3	.	.	PUNCT
admet-184	165	1	a	a	DET
admet-184	165	2	selection	selection	NOUN
admet-184	165	3	of	of	ADP
admet-184	165	4	unpublished	unpublished	ADJ
admet-184	165	5	completed	complete	VERB
admet-184	165	6	clinical	clinical	ADJ
admet-184	165	7	trials	trial	NOUN
admet-184	165	8	using	use	VERB
admet-184	165	9	intranasal	intranasal	ADJ
admet-184	165	10	insulin	insulin	NOUN
admet-184	165	11	for	for	ADP
admet-184	165	12	either	either	CCONJ
admet-184	165	13	central	central	ADJ
admet-184	165	14	or	or	CCONJ
admet-184	165	15	peripheral	peripheral	ADJ
admet-184	165	16	metabolic	metabolic	NOUN
admet-184	165	17	activity	activity	NOUN
admet-184	165	18	(	(	PUNCT
admet-184	165	19	source	source	NOUN
admet-184	165	20	:	:	PUNCT
admet-184	165	21	www.clinicaltrials.gov	www.clinicaltrials.gov	NOUN
admet-184	165	22	)	)	PUNCT
admet-184	165	23	.	.	PUNCT
admet-184	166	1	study	study	NOUN
admet-184	166	2	/	/	SYM
admet-184	166	3	sponsor	sponsor	NOUN
admet-184	166	4	dose	dose	NOUN
admet-184	166	5	status	status	NOUN
admet-184	166	6	safety	safety	NOUN
admet-184	166	7	and	and	CCONJ
admet-184	166	8	effectiveness	effectiveness	NOUN
admet-184	166	9	study	study	NOUN
admet-184	166	10	of	of	ADP
admet-184	166	11	intranasal	intranasal	ADJ
admet-184	166	12	insulin	insulin	NOUN
admet-184	166	13	glulisine	glulisine	NOUN
admet-184	166	14	on	on	ADP
admet-184	166	15	cognitive	cognitive	ADJ
admet-184	166	16	and	and	CCONJ
admet-184	166	17	memory	memory	NOUN
admet-184	166	18	in	in	ADP
admet-184	166	19	mild	mild	ADJ
admet-184	166	20	-	-	PUNCT
admet-184	166	21	mod	mod	NOUN
admet-184	166	22	ad	ad	NOUN
admet-184	166	23	patients	patient	NOUN
admet-184	166	24	.	.	PUNCT
admet-184	167	1	(	(	PUNCT
admet-184	167	2	nct01436045	nct01436045	ADV
admet-184	167	3	)	)	PUNCT
admet-184	167	4	/	/	SYM
admet-184	167	5	healthpartners	healthpartner	NOUN
admet-184	167	6	institute	institute	VERB
admet-184	167	7	for	for	ADP
admet-184	167	8	education	education	NOUN
admet-184	167	9	and	and	CCONJ
admet-184	167	10	research	research	NOUN
admet-184	167	11	20	20	NUM
admet-184	167	12	iu	iu	ADP
admet-184	167	13	completed	complete	VERB
admet-184	167	14	(	(	PUNCT
admet-184	167	15	2013	2013	NUM
admet-184	167	16	)	)	PUNCT
admet-184	167	17	memory	memory	NOUN
admet-184	167	18	and	and	CCONJ
admet-184	167	19	insulin	insulin	NOUN
admet-184	167	20	in	in	ADP
admet-184	167	21	early	early	ADJ
admet-184	167	22	alzheimer	alzheimer	PROPN
admet-184	167	23	's	's	PART
admet-184	167	24	disease	disease	NOUN
admet-184	167	25	(	(	PUNCT
admet-184	167	26	nct00581867	nct00581867	NOUN
admet-184	167	27	)	)	PUNCT
admet-184	167	28	/	/	SYM
admet-184	167	29	university	university	NOUN
admet-184	167	30	of	of	ADP
admet-184	167	31	kansas	kansas	PROPN
admet-184	167	32	40	40	NUM
admet-184	167	33	iu	iu	ADP
admet-184	167	34	completed	complete	VERB
admet-184	167	35	(	(	PUNCT
admet-184	167	36	2013	2013	NUM
admet-184	167	37	)	)	PUNCT
admet-184	167	38	safety	safety	NOUN
admet-184	167	39	study	study	NOUN
admet-184	167	40	of	of	ADP
admet-184	167	41	intranasal	intranasal	ADJ
admet-184	167	42	insulin	insulin	NOUN
admet-184	167	43	in	in	ADP
admet-184	167	44	type	type	NOUN
admet-184	167	45	1	1	NUM
admet-184	167	46	diabetes	diabetes	NOUN
admet-184	167	47	and	and	CCONJ
admet-184	167	48	diabetic	diabetic	ADJ
admet-184	167	49	peripheral	peripheral	ADJ
admet-184	167	50	neuropathy	neuropathy	ADJ
admet-184	167	51	(	(	PUNCT
admet-184	167	52	nct01469559	nct01469559	NOUN
admet-184	167	53	)	)	PUNCT
admet-184	167	54	/	/	SYM
admet-184	167	55	university	university	NOUN
admet-184	167	56	of	of	ADP
admet-184	167	57	calgary	calgary	PROPN
admet-184	167	58	20	20	NUM
admet-184	167	59	iu	iu	ADP
admet-184	167	60	completed	complete	VERB
admet-184	167	61	(	(	PUNCT
admet-184	167	62	2012	2012	NUM
admet-184	167	63	)	)	PUNCT
admet-184	167	64	a	a	DET
admet-184	167	65	study	study	NOUN
admet-184	167	66	to	to	PART
admet-184	167	67	evaluate	evaluate	VERB
admet-184	167	68	the	the	DET
admet-184	167	69	effect	effect	NOUN
admet-184	167	70	of	of	ADP
admet-184	167	71	nasal	nasal	ADJ
admet-184	167	72	insulin	insulin	NOUN
admet-184	167	73	on	on	ADP
admet-184	167	74	postprandial	postprandial	ADJ
admet-184	167	75	glycemic	glycemic	ADJ
admet-184	167	76	control	control	NOUN
admet-184	167	77	in	in	ADP
admet-184	167	78	type	type	NOUN
admet-184	167	79	2	2	NUM
admet-184	167	80	diabetic	diabetic	ADJ
admet-184	167	81	patients	patient	NOUN
admet-184	167	82	(	(	PUNCT
admet-184	167	83	nct00624767	nct00624767	ADJ
admet-184	167	84	)	)	PUNCT
admet-184	167	85	/	/	SYM
admet-184	167	86	nastech	nastech	NOUN
admet-184	167	87	pharmaceutical	pharmaceutical	NOUN
admet-184	167	88	company	company	NOUN
admet-184	167	89	,	,	PUNCT
admet-184	167	90	inc	inc	PROPN
admet-184	167	91	.	.	PROPN
admet-184	167	92	30	30	NUM
admet-184	167	93	iu	iu	ADV
admet-184	167	94	completed	complete	VERB
admet-184	167	95	(	(	PUNCT
admet-184	167	96	2008	2008	NUM
admet-184	167	97	)	)	PUNCT
admet-184	167	98	medical	medical	ADJ
admet-184	167	99	devices	device	NOUN
admet-184	167	100	and	and	CCONJ
admet-184	167	101	dosage	dosage	NOUN
admet-184	167	102	forms	form	NOUN
admet-184	167	103	for	for	ADP
admet-184	167	104	intranasal	intranasal	ADJ
admet-184	167	105	delivery	delivery	NOUN
admet-184	167	106	one	one	NUM
admet-184	167	107	of	of	ADP
admet-184	167	108	the	the	DET
admet-184	167	109	first	first	ADJ
admet-184	167	110	studies	study	NOUN
admet-184	167	111	by	by	ADP
admet-184	167	112	born	bear	VERB
admet-184	167	113	et	et	PROPN
admet-184	167	114	al	al	PROPN
admet-184	167	115	.	.	PROPN
admet-184	168	1	delivered	deliver	VERB
admet-184	168	2	insulin	insulin	NOUN
admet-184	168	3	by	by	ADP
admet-184	168	4	using	use	VERB
admet-184	168	5	a	a	DET
admet-184	168	6	conventional	conventional	ADJ
admet-184	168	7	manual	manual	ADJ
admet-184	168	8	nasal	nasal	NOUN
admet-184	168	9	pump	pump	NOUN
admet-184	168	10	spray	spray	NOUN
admet-184	168	11	atomizer	atomizer	NOUN
admet-184	168	12	[	[	X
admet-184	168	13	52	52	NUM
admet-184	168	14	]	]	PUNCT
admet-184	168	15	that	that	PRON
admet-184	168	16	generates	generate	VERB
admet-184	168	17	droplets	droplet	NOUN
admet-184	168	18	of	of	ADP
admet-184	168	19	roughly	roughly	ADV
admet-184	168	20	50	50	NUM
admet-184	168	21	to	to	PART
admet-184	168	22	100	100	NUM
admet-184	168	23	µm	µm	ADP
admet-184	168	24	dependent	dependent	ADJ
admet-184	168	25	from	from	ADP
admet-184	168	26	many	many	ADJ
admet-184	168	27	different	different	ADJ
admet-184	168	28	factors	factor	NOUN
admet-184	168	29	like	like	ADP
admet-184	168	30	pressure	pressure	NOUN
admet-184	168	31	and	and	CCONJ
admet-184	168	32	distance	distance	NOUN
admet-184	168	33	to	to	ADP
admet-184	168	34	the	the	DET
admet-184	168	35	nozzle	nozzle	NOUN
admet-184	169	1	[	[	X
admet-184	169	2	69,70	69,70	NOUN
admet-184	169	3	]	]	PUNCT
admet-184	169	4	.	.	PUNCT
admet-184	170	1	hence	hence	ADV
admet-184	170	2	,	,	PUNCT
admet-184	170	3	the	the	DET
admet-184	170	4	handling	handling	NOUN
admet-184	170	5	of	of	ADP
admet-184	170	6	device	device	NOUN
admet-184	170	7	by	by	ADP
admet-184	170	8	different	different	ADJ
admet-184	170	9	patients	patient	NOUN
admet-184	170	10	or	or	CCONJ
admet-184	170	11	caregivers	caregiver	NOUN
admet-184	170	12	may	may	AUX
admet-184	170	13	vary	vary	VERB
admet-184	170	14	easily	easily	ADV
admet-184	170	15	and	and	CCONJ
admet-184	170	16	result	result	VERB
admet-184	170	17	in	in	ADP
admet-184	170	18	deposition	deposition	NOUN
admet-184	170	19	at	at	ADP
admet-184	170	20	different	different	ADJ
admet-184	170	21	sites	site	NOUN
admet-184	170	22	of	of	ADP
admet-184	170	23	the	the	DET
admet-184	170	24	nasal	nasal	PROPN
admet-184	170	25	mucosa	mucosa	PROPN
admet-184	170	26	.	.	PUNCT
admet-184	171	1	moreover	moreover	ADV
admet-184	171	2	,	,	PUNCT
admet-184	171	3	aerosols	aerosol	NOUN
admet-184	171	4	delivered	deliver	VERB
admet-184	171	5	by	by	ADP
admet-184	171	6	nasal	nasal	PROPN
admet-184	171	7	pump	pump	PROPN
admet-184	171	8	sprays	spray	NOUN
admet-184	171	9	cleared	clear	VERB
admet-184	171	10	rather	rather	ADV
admet-184	171	11	quickly	quickly	ADV
admet-184	171	12	:	:	PUNCT
admet-184	171	13	about	about	ADV
admet-184	171	14	50	50	NUM
admet-184	171	15	%	%	NOUN
admet-184	171	16	was	be	AUX
admet-184	171	17	cleared	clear	VERB
admet-184	171	18	after	after	ADP
admet-184	171	19	15	15	NUM
admet-184	171	20	minutes	minute	NOUN
admet-184	171	21	,	,	PUNCT
admet-184	171	22	and	and	CCONJ
admet-184	171	23	after	after	ADP
admet-184	171	24	6	6	NUM
admet-184	171	25	hours	hour	NOUN
admet-184	171	26	,	,	PUNCT
admet-184	171	27	less	less	ADJ
admet-184	171	28	than	than	ADP
admet-184	171	29	5	5	NUM
admet-184	171	30	%	%	NOUN
admet-184	171	31	of	of	ADP
admet-184	171	32	activity	activity	NOUN
admet-184	171	33	was	be	AUX
admet-184	171	34	retained	retain	VERB
admet-184	171	35	in	in	ADP
admet-184	171	36	the	the	DET
admet-184	171	37	nose	nose	NOUN
admet-184	172	1	[	[	X
admet-184	172	2	69	69	NUM
admet-184	172	3	]	]	PUNCT
admet-184	172	4	.	.	PUNCT
admet-184	173	1	the	the	DET
admet-184	173	2	above	above	ADV
admet-184	173	3	-	-	PUNCT
admet-184	173	4	mentioned	mention	VERB
admet-184	173	5	clinical	clinical	ADJ
admet-184	173	6	trials	trial	NOUN
admet-184	173	7	at	at	ADP
admet-184	173	8	washington	washington	PROPN
admet-184	173	9	university	university	PROPN
admet-184	173	10	administered	administer	VERB
admet-184	173	11	insulin	insulin	NOUN
admet-184	173	12	via	via	ADP
admet-184	173	13	aerosols	aerosol	NOUN
admet-184	173	14	http://www.clinicaltrials.gov/	http://www.clinicaltrials.gov/	X
admet-184	173	15	admet	admet	PROPN
admet-184	173	16	&	&	CCONJ
admet-184	173	17	dmpk	dmpk	PROPN
admet-184	173	18	3(3	3(3	NUM
admet-184	173	19	)	)	PUNCT
admet-184	173	20	(	(	PUNCT
admet-184	173	21	2015	2015	NUM
admet-184	173	22	)	)	PUNCT
admet-184	173	23	190	190	NUM
admet-184	173	24	-	-	SYM
admet-184	173	25	202	202	NUM
admet-184	173	26	intranasal	intranasal	ADJ
admet-184	173	27	insulin	insulin	NOUN
admet-184	173	28	as	as	ADP
admet-184	173	29	hope	hope	NOUN
admet-184	173	30	for	for	ADP
admet-184	173	31	ad	ad	NOUN
admet-184	173	32	?	?	PUNCT
admet-184	174	1	doi	doi	NOUN
admet-184	174	2	:	:	PUNCT
admet-184	174	3	10.5599	10.5599	NUM
admet-184	174	4	/	/	SYM
admet-184	174	5	admet.3.3.184	admet.3.3.184	SYM
admet-184	174	6	197	197	NUM
admet-184	174	7	generated	generate	VERB
admet-184	174	8	with	with	ADP
admet-184	174	9	the	the	DET
admet-184	174	10	electronic	electronic	ADJ
admet-184	174	11	atomizer	atomizer	NOUN
admet-184	174	12	vianase	vianase	NOUN
admet-184	174	13	™	™	PUNCT
admet-184	174	14	(	(	PUNCT
admet-184	174	15	kurve	kurve	PROPN
admet-184	174	16	technology	technology	PROPN
admet-184	174	17	inc	inc	PROPN
admet-184	174	18	.	.	PROPN
admet-184	174	19	)	)	PUNCT
admet-184	174	20	,	,	PUNCT
admet-184	174	21	a	a	DET
admet-184	174	22	vortex	vortex	NOUN
admet-184	174	23	-	-	PUNCT
admet-184	174	24	propelled	propel	VERB
admet-184	174	25	nebulizer	nebulizer	NOUN
admet-184	174	26	system	system	NOUN
admet-184	174	27	.	.	PUNCT
admet-184	175	1	the	the	DET
admet-184	175	2	vianase	vianase	NOUN
admet-184	175	3	device	device	NOUN
admet-184	175	4	generates	generate	VERB
admet-184	175	5	nebulized	nebulized	ADJ
admet-184	175	6	particles	particle	NOUN
admet-184	175	7	between	between	ADP
admet-184	175	8	9	9	NUM
admet-184	175	9	and	and	CCONJ
admet-184	175	10	11	11	NUM
admet-184	175	11	μm	μm	NOUN
admet-184	175	12	in	in	ADP
admet-184	175	13	size	size	NOUN
admet-184	175	14	to	to	PART
admet-184	175	15	be	be	AUX
admet-184	175	16	inhaled	inhale	VERB
admet-184	175	17	with	with	ADP
admet-184	175	18	an	an	DET
admet-184	175	19	occlusive	occlusive	ADJ
admet-184	175	20	nosepiece	nosepiece	NOUN
admet-184	175	21	over	over	ADP
admet-184	175	22	2	2	NUM
admet-184	175	23	minutes	minute	NOUN
admet-184	175	24	[	[	X
admet-184	175	25	69,71	69,71	NUM
admet-184	175	26	]	]	PUNCT
admet-184	175	27	.	.	PUNCT
admet-184	176	1	according	accord	VERB
admet-184	176	2	to	to	ADP
admet-184	176	3	the	the	DET
admet-184	176	4	manufacturer	manufacturer	NOUN
admet-184	176	5	,	,	PUNCT
admet-184	176	6	this	this	DET
admet-184	176	7	electric	electric	ADJ
admet-184	176	8	device	device	NOUN
admet-184	176	9	covers	cover	VERB
admet-184	176	10	a	a	DET
admet-184	176	11	higher	high	ADJ
admet-184	176	12	content	content	NOUN
admet-184	176	13	of	of	ADP
admet-184	176	14	the	the	DET
admet-184	176	15	nasal	nasal	ADJ
admet-184	176	16	mucosa	mucosa	NOUN
admet-184	176	17	with	with	ADP
admet-184	176	18	drug	drug	NOUN
admet-184	176	19	-	-	PUNCT
admet-184	176	20	containing	contain	VERB
admet-184	176	21	droplets	droplet	NOUN
admet-184	176	22	compared	compare	VERB
admet-184	176	23	to	to	ADP
admet-184	176	24	nasal	nasal	PROPN
admet-184	176	25	pump	pump	NOUN
admet-184	176	26	sprays	spray	NOUN
admet-184	176	27	without	without	ADP
admet-184	176	28	targeting	target	VERB
admet-184	176	29	the	the	DET
admet-184	176	30	lungs	lung	NOUN
admet-184	176	31	[	[	X
admet-184	176	32	71,72	71,72	NOUN
admet-184	176	33	]	]	PUNCT
admet-184	176	34	.	.	PUNCT
admet-184	177	1	a	a	DET
admet-184	177	2	bidirectional	bidirectional	ADJ
admet-184	177	3	breath	breath	NOUN
admet-184	177	4	-	-	PUNCT
admet-184	177	5	powered	power	VERB
admet-184	177	6	nasal	nasal	NOUN
admet-184	177	7	delivery	delivery	NOUN
admet-184	177	8	platform	platform	NOUN
admet-184	177	9	is	be	AUX
admet-184	177	10	optimist	optimist	NOUN
admet-184	177	11	™	™	ADJ
admet-184	177	12	by	by	ADP
admet-184	177	13	optinose	optinose	NUM
admet-184	177	14	.	.	PUNCT
admet-184	178	1	the	the	DET
admet-184	178	2	novel	novel	ADJ
admet-184	178	3	technology	technology	NOUN
admet-184	178	4	overcomes	overcome	VERB
admet-184	178	5	undesired	undesired	ADJ
admet-184	178	6	pulmonary	pulmonary	ADJ
admet-184	178	7	delivery	delivery	NOUN
admet-184	178	8	by	by	ADP
admet-184	178	9	a	a	DET
admet-184	178	10	breath	breath	NOUN
admet-184	178	11	-	-	PUNCT
admet-184	178	12	actuation	actuation	NOUN
admet-184	178	13	mechanism	mechanism	NOUN
admet-184	178	14	.	.	PUNCT
admet-184	179	1	the	the	DET
admet-184	179	2	mechanism	mechanism	NOUN
admet-184	179	3	is	be	AUX
admet-184	179	4	extraordinarily	extraordinarily	ADV
admet-184	179	5	simple	simple	ADJ
admet-184	179	6	:	:	PUNCT
admet-184	179	7	the	the	DET
admet-184	179	8	device	device	NOUN
admet-184	179	9	has	have	VERB
admet-184	179	10	a	a	DET
admet-184	179	11	nosepiece	nosepiece	NOUN
admet-184	179	12	and	and	CCONJ
admet-184	179	13	a	a	DET
admet-184	179	14	mouthpiece	mouthpiece	NOUN
admet-184	179	15	,	,	PUNCT
admet-184	179	16	which	which	PRON
admet-184	179	17	is	be	AUX
admet-184	179	18	inserted	insert	VERB
admet-184	179	19	into	into	ADP
admet-184	179	20	one	one	NUM
admet-184	179	21	nostril	nostril	NOUN
admet-184	179	22	and	and	CCONJ
admet-184	179	23	the	the	DET
admet-184	179	24	patient	patient	NOUN
admet-184	179	25	blows	blow	VERB
admet-184	179	26	into	into	ADP
admet-184	179	27	the	the	DET
admet-184	179	28	mouthpiece	mouthpiece	NOUN
admet-184	179	29	.	.	PUNCT
admet-184	180	1	exhalation	exhalation	NOUN
admet-184	180	2	pressure	pressure	NOUN
admet-184	180	3	releases	release	VERB
admet-184	180	4	drug	drug	NOUN
admet-184	180	5	as	as	ADP
admet-184	180	6	(	(	PUNCT
admet-184	180	7	solid	solid	ADJ
admet-184	180	8	or	or	CCONJ
admet-184	180	9	fluid	fluid	ADJ
admet-184	180	10	)	)	PUNCT
admet-184	180	11	particles	particle	NOUN
admet-184	180	12	through	through	ADP
admet-184	180	13	the	the	DET
admet-184	180	14	nosepiece	nosepiece	NOUN
admet-184	180	15	into	into	ADP
admet-184	180	16	the	the	DET
admet-184	180	17	nasal	nasal	ADJ
admet-184	180	18	cavity	cavity	NOUN
admet-184	180	19	.	.	PUNCT
admet-184	181	1	exhalation	exhalation	NOUN
admet-184	181	2	closes	close	VERB
admet-184	181	3	the	the	DET
admet-184	181	4	soft	soft	ADJ
admet-184	181	5	palate	palate	NOUN
admet-184	181	6	and	and	CCONJ
admet-184	181	7	the	the	DET
admet-184	181	8	air	air	NOUN
admet-184	181	9	flow	flow	NOUN
admet-184	181	10	can	can	AUX
admet-184	181	11	exit	exit	VERB
admet-184	181	12	through	through	ADP
admet-184	181	13	the	the	DET
admet-184	181	14	other	other	ADJ
admet-184	181	15	nostril	nostril	NOUN
admet-184	181	16	as	as	ADP
admet-184	181	17	bidirectional	bidirectional	ADJ
admet-184	181	18	flow	flow	NOUN
admet-184	181	19	reaching	reach	VERB
admet-184	181	20	both	both	DET
admet-184	181	21	parts	part	NOUN
admet-184	181	22	of	of	ADP
admet-184	181	23	the	the	DET
admet-184	181	24	nasal	nasal	ADJ
admet-184	181	25	septum	septum	NOUN
admet-184	182	1	[	[	X
admet-184	182	2	73	73	NUM
admet-184	182	3	]	]	PUNCT
admet-184	182	4	.	.	PUNCT
admet-184	183	1	through	through	ADP
admet-184	183	2	the	the	DET
admet-184	183	3	closed	closed	ADJ
admet-184	183	4	soft	soft	ADJ
admet-184	183	5	palate	palate	ADJ
admet-184	183	6	drug	drug	NOUN
admet-184	183	7	particles	particle	NOUN
admet-184	183	8	can	can	AUX
admet-184	183	9	not	not	PART
admet-184	183	10	enter	enter	VERB
admet-184	183	11	the	the	DET
admet-184	183	12	lungs	lung	NOUN
admet-184	183	13	[	[	X
admet-184	183	14	74	74	NUM
admet-184	183	15	]	]	PUNCT
admet-184	183	16	.	.	PUNCT
admet-184	184	1	optimist	optimist	NOUN
admet-184	184	2	™	™	PUNCT
admet-184	184	3	generates	generate	VERB
admet-184	184	4	droplets	droplet	NOUN
admet-184	184	5	of	of	ADP
admet-184	184	6	43	43	NUM
admet-184	184	7	μm	μm	NOUN
admet-184	184	8	diameter	diameter	NOUN
admet-184	184	9	and	and	CCONJ
admet-184	184	10	targets	target	VERB
admet-184	184	11	larger	large	ADJ
admet-184	184	12	initial	initial	ADJ
admet-184	184	13	and	and	CCONJ
admet-184	184	14	cumulative	cumulative	ADJ
admet-184	184	15	deposition	deposition	NOUN
admet-184	184	16	in	in	ADP
admet-184	184	17	the	the	DET
admet-184	184	18	upper	upper	ADJ
admet-184	184	19	posterior	posterior	ADJ
admet-184	184	20	sector	sector	NOUN
admet-184	184	21	of	of	ADP
admet-184	184	22	the	the	DET
admet-184	184	23	nasal	nasal	ADJ
admet-184	184	24	cavities	cavity	NOUN
admet-184	184	25	and	and	CCONJ
admet-184	184	26	significantly	significantly	ADV
admet-184	184	27	lower	low	ADJ
admet-184	184	28	deposition	deposition	NOUN
admet-184	184	29	in	in	ADP
admet-184	184	30	the	the	DET
admet-184	184	31	anterior	anterior	ADJ
admet-184	184	32	segment	segment	NOUN
admet-184	184	33	.	.	PUNCT
admet-184	185	1	the	the	DET
admet-184	185	2	device	device	NOUN
admet-184	185	3	is	be	AUX
admet-184	185	4	currently	currently	ADV
admet-184	185	5	evaluated	evaluate	VERB
admet-184	185	6	in	in	ADP
admet-184	185	7	a	a	DET
admet-184	185	8	clinical	clinical	ADJ
admet-184	185	9	study	study	NOUN
admet-184	185	10	for	for	ADP
admet-184	185	11	the	the	DET
admet-184	185	12	use	use	NOUN
admet-184	185	13	with	with	ADP
admet-184	185	14	the	the	DET
admet-184	185	15	peptide	peptide	ADJ
admet-184	185	16	oxytocin	oxytocin	PROPN
admet-184	185	17	.	.	PUNCT
admet-184	186	1	pressure	pressure	NOUN
admet-184	186	2	operated	operate	VERB
admet-184	186	3	devices	device	NOUN
admet-184	186	4	aim	aim	VERB
admet-184	186	5	to	to	PART
admet-184	186	6	work	work	VERB
admet-184	186	7	as	as	ADP
admet-184	186	8	precision	precision	NOUN
admet-184	186	9	olfactory	olfactory	NOUN
admet-184	186	10	delivery	delivery	NOUN
admet-184	186	11	(	(	PUNCT
admet-184	186	12	pod	pod	NOUN
admet-184	186	13	®	®	NOUN
admet-184	186	14	,	,	PUNCT
admet-184	186	15	impel	impel	ADJ
admet-184	186	16	neuropharma	neuropharma	NOUN
admet-184	186	17	)	)	PUNCT
admet-184	186	18	devices	device	NOUN
admet-184	186	19	to	to	PART
admet-184	186	20	deliver	deliver	VERB
admet-184	186	21	drugs	drug	NOUN
admet-184	186	22	to	to	ADP
admet-184	186	23	the	the	DET
admet-184	186	24	upper	upper	ADJ
admet-184	186	25	nasal	nasal	NOUN
admet-184	186	26	cavity	cavity	NOUN
admet-184	186	27	for	for	ADP
admet-184	186	28	direct	direct	ADJ
admet-184	186	29	n2b	n2b	PROPN
admet-184	186	30	transport	transport	NOUN
admet-184	186	31	.	.	PUNCT
admet-184	187	1	according	accord	VERB
admet-184	187	2	to	to	ADP
admet-184	187	3	the	the	DET
admet-184	187	4	manufacturer	manufacturer	NOUN
admet-184	187	5	the	the	DET
admet-184	187	6	pod	pod	NOUN
admet-184	187	7	device	device	NOUN
admet-184	187	8	technology	technology	NOUN
admet-184	187	9	results	result	VERB
admet-184	187	10	in	in	ADP
admet-184	187	11	over	over	ADP
admet-184	187	12	50	50	NUM
admet-184	187	13	%	%	NOUN
admet-184	187	14	deposition	deposition	NOUN
admet-184	187	15	at	at	ADP
admet-184	187	16	the	the	DET
admet-184	187	17	olfactory	olfactory	ADJ
admet-184	187	18	region	region	NOUN
admet-184	187	19	and	and	CCONJ
admet-184	187	20	enhanced	enhance	VERB
admet-184	187	21	uptake	uptake	ADJ
admet-184	187	22	into	into	ADP
admet-184	187	23	the	the	DET
admet-184	187	24	cns	cns	NOUN
admet-184	187	25	in	in	ADP
admet-184	187	26	comparison	comparison	NOUN
admet-184	187	27	to	to	ADP
admet-184	187	28	other	other	ADJ
admet-184	187	29	nasal	nasal	PROPN
admet-184	187	30	delivery	delivery	NOUN
admet-184	187	31	devices	device	NOUN
admet-184	187	32	,	,	PUNCT
admet-184	187	33	which	which	PRON
admet-184	187	34	are	be	AUX
admet-184	187	35	quickly	quickly	ADV
admet-184	187	36	cleared	clear	VERB
admet-184	187	37	by	by	ADP
admet-184	187	38	respiratory	respiratory	ADJ
admet-184	187	39	epithelium	epithelium	NOUN
admet-184	187	40	and	and	CCONJ
admet-184	187	41	absorbed	absorb	VERB
admet-184	187	42	into	into	ADP
admet-184	187	43	systemic	systemic	ADJ
admet-184	187	44	circulation	circulation	NOUN
admet-184	187	45	[	[	X
admet-184	187	46	75	75	NUM
admet-184	187	47	]	]	PUNCT
admet-184	187	48	.	.	PUNCT
admet-184	188	1	in	in	ADP
admet-184	188	2	addition	addition	NOUN
admet-184	188	3	,	,	PUNCT
admet-184	188	4	standard	standard	ADJ
admet-184	188	5	medical	medical	ADJ
admet-184	188	6	nebulizers	nebulizer	NOUN
admet-184	188	7	can	can	AUX
admet-184	188	8	be	be	AUX
admet-184	188	9	used	use	VERB
admet-184	188	10	for	for	ADP
admet-184	188	11	aerosol	aerosol	NOUN
admet-184	188	12	generation	generation	NOUN
admet-184	188	13	and	and	CCONJ
admet-184	188	14	delivery	delivery	NOUN
admet-184	188	15	into	into	ADP
admet-184	188	16	the	the	DET
admet-184	188	17	nasal	nasal	ADJ
admet-184	188	18	cavity	cavity	NOUN
admet-184	188	19	.	.	PUNCT
admet-184	189	1	however	however	ADV
admet-184	189	2	,	,	PUNCT
admet-184	189	3	most	most	ADJ
admet-184	189	4	of	of	ADP
admet-184	189	5	them	they	PRON
admet-184	189	6	have	have	AUX
admet-184	189	7	been	be	AUX
admet-184	189	8	developed	develop	VERB
admet-184	189	9	to	to	PART
admet-184	189	10	target	target	VERB
admet-184	189	11	the	the	DET
admet-184	189	12	lower	low	ADJ
admet-184	189	13	airways	airway	NOUN
admet-184	189	14	,	,	PUNCT
admet-184	189	15	but	but	CCONJ
admet-184	189	16	newer	new	ADJ
admet-184	189	17	models	model	NOUN
admet-184	189	18	engineered	engineer	VERB
admet-184	189	19	for	for	ADP
admet-184	189	20	the	the	DET
admet-184	189	21	delivery	delivery	NOUN
admet-184	189	22	of	of	ADP
admet-184	189	23	the	the	DET
admet-184	189	24	paranasal	paranasal	ADJ
admet-184	189	25	sinuses	sinus	NOUN
admet-184	189	26	(	(	PUNCT
admet-184	189	27	e.	e.	PROPN
admet-184	189	28	g.	g.	PROPN
admet-184	189	29	pari	pari	PROPN
admet-184	189	30	sinus	sinus	PROPN
admet-184	189	31	™	™	NOUN
admet-184	189	32	)	)	PUNCT
admet-184	189	33	might	might	AUX
admet-184	189	34	be	be	AUX
admet-184	189	35	suitable	suitable	ADJ
admet-184	189	36	for	for	ADP
admet-184	189	37	n2b	n2b	NOUN
admet-184	189	38	delivery	delivery	NOUN
admet-184	189	39	.	.	PUNCT
admet-184	190	1	the	the	DET
admet-184	190	2	influence	influence	NOUN
admet-184	190	3	of	of	ADP
admet-184	190	4	liposomes	liposome	NOUN
admet-184	190	5	,	,	PUNCT
admet-184	190	6	nanoparticle	nanoparticle	NOUN
admet-184	190	7	and	and	CCONJ
admet-184	190	8	gels	gel	NOUN
admet-184	190	9	as	as	SCONJ
admet-184	190	10	dosage	dosage	NOUN
admet-184	190	11	forms	form	NOUN
admet-184	190	12	for	for	ADP
admet-184	190	13	intranasal	intranasal	ADJ
admet-184	190	14	delivery	delivery	NOUN
admet-184	190	15	is	be	AUX
admet-184	190	16	summarized	summarize	VERB
admet-184	190	17	in	in	ADP
admet-184	190	18	table	table	NOUN
admet-184	190	19	2	2	NUM
admet-184	190	20	.	.	X
admet-184	190	21	intranasal	intranasal	ADJ
admet-184	190	22	insulin	insulin	NOUN
admet-184	190	23	for	for	ADP
admet-184	190	24	metabolic	metabolic	NOUN
admet-184	190	25	diseases	disease	NOUN
admet-184	190	26	n2b	n2b	PROPN
admet-184	190	27	insulin	insulin	NOUN
admet-184	190	28	delivery	delivery	NOUN
admet-184	190	29	appears	appear	VERB
admet-184	190	30	to	to	PART
admet-184	190	31	be	be	AUX
admet-184	190	32	a	a	DET
admet-184	190	33	clinically	clinically	ADV
admet-184	190	34	safe	safe	ADJ
admet-184	190	35	application	application	NOUN
admet-184	190	36	method	method	NOUN
admet-184	190	37	for	for	ADP
admet-184	190	38	the	the	DET
admet-184	190	39	dissociation	dissociation	NOUN
admet-184	190	40	of	of	ADP
admet-184	190	41	central	central	ADJ
admet-184	190	42	and	and	CCONJ
admet-184	190	43	peripheral	peripheral	ADJ
admet-184	190	44	insulin	insulin	NOUN
admet-184	190	45	effects	effect	NOUN
admet-184	190	46	[	[	X
admet-184	190	47	76	76	NUM
admet-184	190	48	]	]	PUNCT
admet-184	190	49	.	.	PUNCT
admet-184	191	1	an	an	DET
admet-184	191	2	intranasal	intranasal	ADJ
admet-184	191	3	insulin	insulin	NOUN
admet-184	191	4	spray	spray	NOUN
admet-184	191	5	containing	contain	VERB
admet-184	191	6	the	the	DET
admet-184	191	7	adsorption	adsorption	NOUN
admet-184	191	8	enhancer	enhancer	NOUN
admet-184	191	9	cyclopentadecalactone	cyclopentadecalactone	NOUN
admet-184	191	10	(	(	PUNCT
admet-184	191	11	cpe-215	cpe-215	PROPN
admet-184	191	12	)	)	PUNCT
admet-184	191	13	was	be	AUX
admet-184	191	14	developed	develop	VERB
admet-184	191	15	as	as	ADP
admet-184	191	16	nasulin	nasulin	NOUN
admet-184	191	17	™	™	PROPN
admet-184	191	18	for	for	ADP
admet-184	191	19	the	the	DET
admet-184	191	20	needle	needle	NOUN
admet-184	191	21	-	-	PUNCT
admet-184	191	22	free	free	ADJ
admet-184	191	23	regimen	regiman	NOUN
admet-184	191	24	of	of	ADP
admet-184	191	25	diabetes	diabetes	NOUN
admet-184	191	26	.	.	PUNCT
admet-184	192	1	the	the	DET
admet-184	192	2	programme	programme	NOUN
admet-184	192	3	was	be	AUX
admet-184	192	4	stopped	stop	VERB
admet-184	192	5	after	after	ADP
admet-184	192	6	disappointing	disappointing	ADJ
admet-184	192	7	results	result	NOUN
admet-184	192	8	of	of	ADP
admet-184	192	9	a	a	DET
admet-184	192	10	phase	phase	NOUN
admet-184	192	11	2a	2a	NUM
admet-184	192	12	proof	proof	NOUN
admet-184	192	13	-	-	PUNCT
admet-184	192	14	of	of	ADP
admet-184	192	15	-	-	PUNCT
admet-184	192	16	concept	concept	NOUN
admet-184	192	17	clinical	clinical	ADJ
admet-184	192	18	trial	trial	NOUN
admet-184	192	19	[	[	X
admet-184	192	20	77	77	NUM
admet-184	192	21	]	]	PUNCT
admet-184	192	22	.	.	PUNCT
admet-184	193	1	the	the	DET
admet-184	193	2	primary	primary	ADJ
admet-184	193	3	objective	objective	NOUN
admet-184	193	4	to	to	PART
admet-184	193	5	demonstrate	demonstrate	VERB
admet-184	193	6	that	that	SCONJ
admet-184	193	7	subjects	subject	NOUN
admet-184	193	8	receiving	receive	VERB
admet-184	193	9	nasulin	nasulin	NOUN
admet-184	193	10	™	™	PROPN
admet-184	193	11	would	would	AUX
admet-184	193	12	achieve	achieve	VERB
admet-184	193	13	a	a	DET
admet-184	193	14	larger	large	ADJ
admet-184	193	15	increase	increase	NOUN
admet-184	193	16	from	from	ADP
admet-184	193	17	baseline	baseline	NOUN
admet-184	193	18	in	in	ADP
admet-184	193	19	the	the	DET
admet-184	193	20	mean	mean	ADJ
admet-184	193	21	proportion	proportion	NOUN
admet-184	193	22	of	of	ADP
admet-184	193	23	time	time	NOUN
admet-184	193	24	spent	spend	VERB
admet-184	193	25	in	in	ADP
admet-184	193	26	euglycemia	euglycemia	NOUN
admet-184	193	27	than	than	ADP
admet-184	193	28	those	those	PRON
admet-184	193	29	receiving	receive	VERB
admet-184	193	30	placebo	placebo	NOUN
admet-184	193	31	failed	fail	VERB
admet-184	193	32	statistical	statistical	ADJ
admet-184	193	33	significance	significance	NOUN
admet-184	193	34	.	.	PUNCT
admet-184	194	1	like	like	INTJ
admet-184	194	2	in	in	ADP
admet-184	194	3	the	the	DET
admet-184	194	4	latter	latter	ADJ
admet-184	194	5	ad	ad	NOUN
admet-184	194	6	trials	trial	NOUN
admet-184	194	7	,	,	PUNCT
admet-184	194	8	no	no	DET
admet-184	194	9	critical	critical	ADJ
admet-184	194	10	safety	safety	NOUN
admet-184	194	11	signals	signal	NOUN
admet-184	194	12	were	be	AUX
admet-184	194	13	detected	detect	VERB
admet-184	194	14	with	with	ADP
admet-184	194	15	nasulin	nasulin	PROPN
admet-184	194	16	™	™	PROPN
admet-184	194	17	.	.	PUNCT
admet-184	195	1	the	the	DET
admet-184	195	2	most	most	ADV
admet-184	195	3	common	common	ADJ
admet-184	195	4	adverse	adverse	ADJ
admet-184	195	5	events	event	NOUN
admet-184	195	6	were	be	AUX
admet-184	195	7	those	those	PRON
admet-184	195	8	attributable	attributable	ADJ
admet-184	195	9	to	to	ADP
admet-184	195	10	administration	administration	NOUN
admet-184	195	11	site	site	NOUN
admet-184	195	12	reactions	reaction	NOUN
admet-184	195	13	associated	associate	VERB
admet-184	195	14	with	with	ADP
admet-184	195	15	the	the	DET
admet-184	195	16	nasal	nasal	PROPN
admet-184	195	17	route	route	NOUN
admet-184	195	18	of	of	ADP
admet-184	195	19	delivery	delivery	NOUN
admet-184	195	20	,	,	PUNCT
admet-184	195	21	the	the	DET
admet-184	195	22	majority	majority	NOUN
admet-184	195	23	of	of	ADP
admet-184	195	24	which	which	PRON
admet-184	195	25	were	be	AUX
admet-184	195	26	mild	mild	ADJ
admet-184	195	27	.	.	PUNCT
admet-184	196	1	the	the	DET
admet-184	196	2	percentage	percentage	NOUN
admet-184	196	3	of	of	ADP
admet-184	196	4	subjects	subject	NOUN
admet-184	196	5	reporting	report	VERB
admet-184	196	6	hypoglycemia	hypoglycemia	NOUN
admet-184	196	7	was	be	AUX
admet-184	196	8	similar	similar	ADJ
admet-184	196	9	between	between	ADP
admet-184	196	10	both	both	CCONJ
admet-184	196	11	the	the	DET
admet-184	196	12	nasulin	nasulin	NOUN
admet-184	196	13	™	™	ADJ
admet-184	196	14	and	and	CCONJ
admet-184	196	15	placebo	placebo	NOUN
admet-184	196	16	groups	group	NOUN
admet-184	196	17	.	.	PUNCT
admet-184	197	1	nevertheless	nevertheless	ADV
admet-184	197	2	,	,	PUNCT
admet-184	197	3	it	it	PRON
admet-184	197	4	seems	seem	VERB
admet-184	197	5	that	that	SCONJ
admet-184	197	6	intranasal	intranasal	ADJ
admet-184	197	7	insulin	insulin	NOUN
admet-184	197	8	is	be	AUX
admet-184	197	9	yet	yet	ADV
admet-184	197	10	not	not	PART
admet-184	197	11	dead	dead	ADJ
admet-184	197	12	.	.	PUNCT
admet-184	198	1	the	the	DET
admet-184	198	2	fda	fda	PROPN
admet-184	198	3	gave	give	VERB
admet-184	198	4	a	a	DET
admet-184	198	5	black	black	ADJ
admet-184	198	6	box	box	NOUN
admet-184	198	7	warning	warn	VERB
admet-184	198	8	to	to	ADP
admet-184	198	9	the	the	DET
admet-184	198	10	pulmonary	pulmonary	NOUN
admet-184	198	11	administered	administer	VERB
admet-184	198	12	insulin	insulin	NOUN
admet-184	198	13	exubera	exubera	NOUN
admet-184	198	14	®	®	NOUN
admet-184	198	15	since	since	SCONJ
admet-184	198	16	clinical	clinical	ADJ
admet-184	198	17	studies	study	NOUN
admet-184	198	18	reported	report	VERB
admet-184	198	19	a	a	DET
admet-184	198	20	four	four	NUM
admet-184	198	21	-	-	ADJ
admet-184	198	22	fold	fold	ADJ
admet-184	198	23	increase	increase	NOUN
admet-184	198	24	in	in	ADP
admet-184	198	25	the	the	DET
admet-184	198	26	incidence	incidence	NOUN
admet-184	198	27	of	of	ADP
admet-184	198	28	lung	lung	NOUN
admet-184	198	29	cancer	cancer	NOUN
admet-184	198	30	among	among	ADP
admet-184	198	31	patients	patient	NOUN
admet-184	198	32	with	with	ADP
admet-184	198	33	a	a	DET
admet-184	198	34	history	history	NOUN
admet-184	198	35	of	of	ADP
admet-184	198	36	smoking	smoking	NOUN
admet-184	198	37	.	.	PUNCT
admet-184	199	1	in	in	ADP
admet-184	199	2	2007	2007	NUM
admet-184	199	3	exubera	exubera	NOUN
admet-184	199	4	®	®	NOUN
admet-184	199	5	was	be	AUX
admet-184	199	6	discontinued	discontinue	VERB
admet-184	199	7	and	and	CCONJ
admet-184	199	8	shifted	shift	VERB
admet-184	199	9	back	back	ADV
admet-184	199	10	the	the	DET
admet-184	199	11	interest	interest	NOUN
admet-184	199	12	to	to	ADP
admet-184	199	13	nasal	nasal	PROPN
admet-184	199	14	insulin	insulin	NOUN
admet-184	199	15	administration	administration	NOUN
admet-184	199	16	with	with	ADP
admet-184	199	17	very	very	ADV
admet-184	199	18	recent	recent	ADJ
admet-184	199	19	studies	study	NOUN
admet-184	199	20	on	on	ADP
admet-184	199	21	beneficial	beneficial	ADJ
admet-184	199	22	metabolic	metabolic	NOUN
admet-184	199	23	effects	effect	NOUN
admet-184	199	24	of	of	ADP
admet-184	199	25	central	central	ADJ
admet-184	199	26	insulin	insulin	NOUN
admet-184	199	27	action	action	NOUN
admet-184	200	1	[	[	X
admet-184	200	2	59,66,78	59,66,78	NUM
admet-184	200	3	]	]	PUNCT
admet-184	200	4	.	.	PUNCT
admet-184	201	1	several	several	ADJ
admet-184	201	2	companies	company	NOUN
admet-184	201	3	continue	continue	VERB
admet-184	201	4	their	their	PRON
admet-184	201	5	nasal	nasal	ADJ
admet-184	201	6	insulin	insulin	NOUN
admet-184	201	7	development	development	NOUN
admet-184	201	8	programmes	programme	NOUN
admet-184	201	9	for	for	ADP
admet-184	201	10	the	the	DET
admet-184	201	11	regimen	regiman	NOUN
admet-184	201	12	of	of	ADP
admet-184	201	13	diabetes	diabetes	NOUN
admet-184	201	14	,	,	PUNCT
admet-184	201	15	all	all	PRON
admet-184	201	16	of	of	ADP
admet-184	201	17	them	they	PRON
admet-184	201	18	m.	m.	NOUN
admet-184	201	19	stützle	stützle	NOUN
admet-184	201	20	,	,	PUNCT
admet-184	201	21	j.	j.	PROPN
admet-184	201	22	flamm	flamm	PROPN
admet-184	201	23	,	,	PUNCT
admet-184	201	24	s.	s.	PROPN
admet-184	201	25	carle	carle	PROPN
admet-184	201	26	and	and	CCONJ
admet-184	201	27	k.	k.	PROPN
admet-184	201	28	schindowski	schindowski	PROPN
admet-184	201	29	admet	admet	PROPN
admet-184	201	30	&	&	CCONJ
admet-184	201	31	dmpk	dmpk	PROPN
admet-184	201	32	3(3	3(3	NUM
admet-184	201	33	)	)	PUNCT
admet-184	201	34	(	(	PUNCT
admet-184	201	35	2015	2015	NUM
admet-184	201	36	)	)	PUNCT
admet-184	201	37	190	190	NUM
admet-184	201	38	-	-	SYM
admet-184	201	39	202	202	NUM
admet-184	201	40	198	198	NUM
admet-184	201	41	using	use	VERB
admet-184	201	42	different	different	ADJ
admet-184	201	43	absorption	absorption	NOUN
admet-184	201	44	enhancers	enhancer	NOUN
admet-184	201	45	like	like	ADP
admet-184	201	46	dodecyl	dodecyl	PROPN
admet-184	201	47	-	-	PUNCT
admet-184	201	48	β	β	NOUN
admet-184	201	49	-	-	PUNCT
admet-184	201	50	d	d	NOUN
admet-184	201	51	-	-	PUNCT
admet-184	201	52	maltoside	maltoside	NOUN
admet-184	201	53	(	(	PUNCT
admet-184	201	54	aegis	aegis	PROPN
admet-184	201	55	therapeutics	therapeutics	PROPN
admet-184	201	56	inc	inc	PROPN
admet-184	201	57	.	.	PUNCT
admet-184	201	58	;	;	PUNCT
admet-184	202	1	[	[	X
admet-184	202	2	79	79	NUM
admet-184	202	3	]	]	SYM
admet-184	202	4	)	)	PUNCT
admet-184	202	5	,	,	PUNCT
admet-184	202	6	micro	micro	X
admet-184	202	7	crystalline	crystalline	NOUN
admet-184	202	8	cellulose	cellulose	NOUN
admet-184	202	9	(	(	PUNCT
admet-184	202	10	snbl	snbl	VERB
admet-184	202	11	;	;	PUNCT
admet-184	202	12	[	[	X
admet-184	202	13	80	80	NUM
admet-184	202	14	]	]	PUNCT
admet-184	202	15	)	)	PUNCT
admet-184	202	16	and	and	CCONJ
admet-184	202	17	criticalsorb	criticalsorb	ADJ
admet-184	202	18	™	™	ADJ
admet-184	202	19	(	(	PUNCT
admet-184	202	20	critical	critical	ADJ
admet-184	202	21	pharmaceuticals	pharmaceutical	NOUN
admet-184	202	22	;	;	PUNCT
admet-184	202	23	[	[	X
admet-184	202	24	81	81	NUM
admet-184	202	25	]	]	PUNCT
admet-184	202	26	)	)	PUNCT
admet-184	202	27	.	.	PUNCT
admet-184	203	1	table	table	NOUN
admet-184	204	1	2	2	NUM
admet-184	204	2	.	.	PUNCT
admet-184	204	3	dosage	dosage	NOUN
admet-184	204	4	forms	form	NOUN
admet-184	204	5	used	use	VERB
admet-184	204	6	in	in	ADP
admet-184	204	7	intranasal	intranasal	ADJ
admet-184	204	8	delivery	delivery	NOUN
admet-184	204	9	.	.	PUNCT
admet-184	205	1	liposomes	liposome	NOUN
admet-184	205	2	study	study	VERB
admet-184	205	3	compound	compound	NOUN
admet-184	205	4	formulation	formulation	NOUN
admet-184	205	5	particle	particle	NOUN
admet-184	205	6	size	size	NOUN
admet-184	205	7	outcome	outcome	NOUN
admet-184	205	8	source	source	NOUN
admet-184	205	9	preclinical/	preclinical/	PRON
admet-184	205	10	rodents	rodent	NOUN
admet-184	205	11	galantamine	galantamine	VERB
admet-184	205	12	hbr	hbr	PROPN
admet-184	205	13	soy	soy	NOUN
admet-184	205	14	phosphatidylcholine	phosphatidylcholine	PROPN
admet-184	205	15	,	,	PUNCT
admet-184	205	16	cholesterol	cholesterol	NOUN
admet-184	205	17	,	,	PUNCT
admet-184	205	18	propylene	propylene	NOUN
admet-184	205	19	glycol	glycol	NOUN
admet-184	205	20	112	112	NUM
admet-184	205	21	±	±	NUM
admet-184	205	22	8	8	NUM
admet-184	205	23	nm	nm	NOUN
admet-184	205	24	2.8	2.8	NUM
admet-184	205	25	-	-	ADJ
admet-184	205	26	fold	fold	ADJ
admet-184	205	27	increase	increase	NOUN
admet-184	205	28	of	of	ADP
admet-184	205	29	auc	auc	NOUN
admet-184	205	30	compared	compare	VERB
admet-184	205	31	to	to	ADP
admet-184	205	32	free	free	ADJ
admet-184	205	33	drug	drug	NOUN
admet-184	205	34	via	via	ADP
admet-184	205	35	n2b	n2b	PROPN
admet-184	205	36	;	;	PUNCT
admet-184	205	37	3.4	3.4	NUM
admet-184	205	38	-	-	ADJ
admet-184	205	39	fold	fold	ADJ
admet-184	205	40	increase	increase	NOUN
admet-184	205	41	compared	compare	VERB
admet-184	205	42	to	to	ADP
admet-184	205	43	oral	oral	ADJ
admet-184	205	44	delivery	delivery	NOUN
admet-184	206	1	[	[	X
admet-184	206	2	82	82	NUM
admet-184	206	3	]	]	X
admet-184	206	4	preclinical/	preclinical/	NUM
admet-184	206	5	rodents	rodent	NOUN
admet-184	206	6	rivastigmine	rivastigmine	ADJ
admet-184	206	7	cholesterol	cholesterol	NOUN
admet-184	206	8	,	,	PUNCT
admet-184	206	9	soy	soy	NOUN
admet-184	206	10	lecitihin	lecitihin	VERB
admet-184	206	11	10	10	NUM
admet-184	206	12	±	±	NUM
admet-184	206	13	2.8	2.8	NUM
admet-184	206	14	µm	µm	ADP
admet-184	206	15	3	3	NUM
admet-184	206	16	-	-	ADJ
admet-184	206	17	fold	fold	ADJ
admet-184	206	18	increase	increase	NOUN
admet-184	206	19	of	of	ADP
admet-184	206	20	auc	auc	NOUN
admet-184	206	21	compared	compare	VERB
admet-184	206	22	to	to	ADP
admet-184	206	23	free	free	ADJ
admet-184	206	24	drug	drug	NOUN
admet-184	206	25	via	via	ADP
admet-184	206	26	n2b	n2b	PROPN
admet-184	206	27	;	;	PUNCT
admet-184	206	28	5.5	5.5	NUM
admet-184	206	29	-	-	ADJ
admet-184	206	30	fold	fold	ADJ
admet-184	206	31	increase	increase	NOUN
admet-184	206	32	compared	compare	VERB
admet-184	206	33	to	to	ADP
admet-184	206	34	oral	oral	ADJ
admet-184	206	35	delivery	delivery	NOUN
admet-184	207	1	[	[	X
admet-184	207	2	83	83	NUM
admet-184	207	3	]	]	SYM
admet-184	207	4	preclinical/	preclinical/	NUM
admet-184	207	5	rodents	rodent	NOUN
admet-184	207	6	ovalbumin	ovalbumin	VERB
admet-184	207	7	as	as	ADP
admet-184	207	8	surrogate	surrogate	ADJ
admet-184	207	9	for	for	ADP
admet-184	207	10	protein	protein	NOUN
admet-184	207	11	therapeutics	therapeutic	NOUN
admet-184	207	12	dioleoylphosphatidylcholine	dioleoylphosphatidylcholine	NOUN
admet-184	207	13	,	,	PUNCT
admet-184	207	14	cholesterol	cholesterol	NOUN
admet-184	207	15	,	,	PUNCT
admet-184	207	16	stearylamine	stearylamine	VERB
admet-184	207	17	299	299	NUM
admet-184	207	18	±	±	NUM
admet-184	207	19	26.4	26.4	NUM
admet-184	207	20	nm	nm	NOUN
admet-184	207	21	>	>	ADP
admet-184	207	22	4	4	NUM
admet-184	207	23	-	-	ADJ
admet-184	207	24	fold	fold	ADJ
admet-184	207	25	higher	high	ADJ
admet-184	207	26	aucbrain	aucbrain	NOUN
admet-184	207	27	/	/	SYM
admet-184	207	28	aucblood	aucblood	NOUN
admet-184	207	29	for	for	ADP
admet-184	207	30	the	the	DET
admet-184	207	31	liposomal	liposomal	ADJ
admet-184	207	32	formulation	formulation	NOUN
admet-184	207	33	compared	compare	VERB
admet-184	207	34	to	to	ADP
admet-184	207	35	the	the	DET
admet-184	207	36	pbs	pbs	PROPN
admet-184	207	37	preparation	preparation	NOUN
admet-184	207	38	[	[	X
admet-184	207	39	84	84	NUM
admet-184	207	40	]	]	PUNCT
admet-184	207	41	nanoparticles	nanoparticle	NOUN
admet-184	207	42	study	study	VERB
admet-184	207	43	compound	compound	NOUN
admet-184	207	44	formulation	formulation	NOUN
admet-184	207	45	particle	particle	NOUN
admet-184	207	46	size	size	NOUN
admet-184	207	47	outcome	outcome	NOUN
admet-184	207	48	source	source	NOUN
admet-184	207	49	preclinical/	preclinical/	PRON
admet-184	207	50	rodents	rodent	NOUN
admet-184	207	51	insulin	insulin	NOUN
admet-184	207	52	(	(	PUNCT
admet-184	207	53	for	for	ADP
admet-184	207	54	blood	blood	NOUN
admet-184	207	55	glucose	glucose	NOUN
admet-184	207	56	management	management	NOUN
admet-184	207	57	)	)	PUNCT
admet-184	207	58	glycopolymer	glycopolymer	NOUN
admet-184	207	59	poly(2	poly(2	NOUN
admet-184	207	60	-	-	PUNCT
admet-184	207	61	lactobionamidoethylmethacrylate	lactobionamidoethylmethacrylate	ADJ
admet-184	207	62	-	-	PUNCT
admet-184	207	63	r-3acrylamidophenylboronic	r-3acrylamidophenylboronic	ADJ
admet-184	207	64	acid	acid	NOUN
admet-184	207	65	)	)	PUNCT
admet-184	207	66	p(lama	p(lama	NOUN
admet-184	207	67	-	-	PUNCT
admet-184	207	68	r	r	NOUN
admet-184	207	69	-	-	PUNCT
admet-184	207	70	aapba	aapba	NOUN
admet-184	207	71	)	)	PUNCT
admet-184	207	72	2:1	2:1	NUM
admet-184	207	73	289.4	289.4	NUM
admet-184	207	74	±	±	NUM
admet-184	207	75	2.5	2.5	NUM
admet-184	207	76	nm	nm	NUM
admet-184	207	77	80	80	NUM
admet-184	207	78	%	%	NOUN
admet-184	207	79	decrease	decrease	NOUN
admet-184	207	80	of	of	ADP
admet-184	207	81	peripheral	peripheral	ADJ
admet-184	207	82	blood	blood	NOUN
admet-184	207	83	glucose	glucose	NOUN
admet-184	207	84	levels	level	NOUN
admet-184	207	85	with	with	ADP
admet-184	207	86	nanoparticles	nanoparticle	NOUN
admet-184	207	87	,	,	PUNCT
admet-184	207	88	4	4	NUM
admet-184	207	89	-	-	ADJ
admet-184	207	90	fold	fold	ADJ
admet-184	207	91	increase	increase	NOUN
admet-184	207	92	compared	compare	VERB
admet-184	207	93	to	to	ADP
admet-184	207	94	pbs	pbs	PROPN
admet-184	207	95	formulation	formulation	NOUN
admet-184	207	96	[	[	NOUN
admet-184	207	97	85	85	NUM
admet-184	207	98	]	]	ADJ
admet-184	207	99	gels	gel	NOUN
admet-184	207	100	study	study	NOUN
admet-184	207	101	compound	compound	NOUN
admet-184	207	102	formulation	formulation	NOUN
admet-184	207	103	outcome	outcome	NOUN
admet-184	207	104	source	source	NOUN
admet-184	207	105	preclinical	preclinical	ADJ
admet-184	207	106	(	(	PUNCT
admet-184	207	107	rodents	rodent	NOUN
admet-184	207	108	)	)	PUNCT
admet-184	207	109	and	and	CCONJ
admet-184	207	110	clinical	clinical	ADJ
admet-184	207	111	(	(	PUNCT
admet-184	207	112	humans	human	NOUN
admet-184	207	113	)	)	PUNCT
admet-184	207	114	study	study	NOUN
admet-184	207	115	insulin	insulin	NOUN
admet-184	207	116	(	(	PUNCT
admet-184	207	117	for	for	ADP
admet-184	207	118	blood	blood	NOUN
admet-184	207	119	glucose	glucose	NOUN
admet-184	207	120	management	management	NOUN
admet-184	207	121	)	)	PUNCT
admet-184	207	122	carbopol	carbopol	NOUN
admet-184	207	123	934p	934p	NOUN
admet-184	207	124	and	and	CCONJ
admet-184	207	125	hydroxypropyl	hydroxypropyl	VERB
admet-184	207	126	methylcellulose	methylcellulose	NOUN
admet-184	207	127	prolonged	prolong	VERB
admet-184	207	128	effect	effect	NOUN
admet-184	207	129	on	on	ADP
admet-184	207	130	blood	blood	NOUN
admet-184	207	131	glucose	glucose	NOUN
admet-184	207	132	levels	level	NOUN
admet-184	207	133	in	in	ADP
admet-184	207	134	rodents	rodent	NOUN
admet-184	207	135	;	;	PUNCT
admet-184	207	136	decrease	decrease	NOUN
admet-184	207	137	of	of	ADP
admet-184	207	138	blood	blood	NOUN
admet-184	207	139	glucose	glucose	NOUN
admet-184	207	140	levels	level	NOUN
admet-184	207	141	by	by	ADP
admet-184	207	142	20	20	NUM
admet-184	207	143	%	%	NOUN
admet-184	207	144	with	with	ADP
admet-184	207	145	nasal	nasal	PROPN
admet-184	207	146	gel	gel	PROPN
admet-184	207	147	,	,	PUNCT
admet-184	207	148	no	no	DET
admet-184	207	149	control	control	NOUN
admet-184	207	150	group	group	NOUN
admet-184	207	151	for	for	ADP
admet-184	207	152	comparison	comparison	NOUN
admet-184	207	153	.	.	PUNCT
admet-184	208	1	[	[	X
admet-184	208	2	86	86	NUM
admet-184	208	3	]	]	X
admet-184	208	4	preclinical/	preclinical/	NUM
admet-184	208	5	rodents	rodent	NOUN
admet-184	208	6	insulin	insulin	NOUN
admet-184	208	7	(	(	PUNCT
admet-184	208	8	for	for	ADP
admet-184	208	9	blood	blood	NOUN
admet-184	208	10	glucose	glucose	NOUN
admet-184	208	11	management	management	NOUN
admet-184	208	12	)	)	PUNCT
admet-184	208	13	chitosan	chitosan	NOUN
admet-184	208	14	and	and	CCONJ
admet-184	208	15	polyvinyl	polyvinyl	NOUN
admet-184	208	16	alcohol	alcohol	NOUN
admet-184	208	17	(	(	PUNCT
admet-184	208	18	pva	pva	NOUN
admet-184	208	19	)	)	PUNCT
admet-184	208	20	prolonged	prolong	VERB
admet-184	208	21	60	60	NUM
admet-184	208	22	%	%	NOUN
admet-184	208	23	decrease	decrease	NOUN
admet-184	208	24	of	of	ADP
admet-184	208	25	peripheral	peripheral	ADJ
admet-184	208	26	blood	blood	NOUN
admet-184	208	27	glucose	glucose	NOUN
admet-184	208	28	levels	level	NOUN
admet-184	208	29	with	with	ADP
admet-184	208	30	gel	gel	NOUN
admet-184	208	31	formulation	formulation	NOUN
admet-184	208	32	[	[	X
admet-184	208	33	87	87	NUM
admet-184	208	34	]	]	PUNCT
admet-184	208	35	conclusive	conclusive	ADJ
admet-184	208	36	remarks	remark	NOUN
admet-184	208	37	about	about	ADP
admet-184	208	38	the	the	DET
admet-184	208	39	lack	lack	NOUN
admet-184	208	40	of	of	ADP
admet-184	208	41	valuable	valuable	ADJ
admet-184	208	42	pk	pk	ADJ
admet-184	208	43	-	-	ADJ
admet-184	208	44	pd	pd	NOUN
admet-184	208	45	studies	study	NOUN
admet-184	208	46	nasal	nasal	ADJ
admet-184	208	47	insulin	insulin	NOUN
admet-184	208	48	delivery	delivery	NOUN
admet-184	208	49	using	use	VERB
admet-184	208	50	such	such	ADJ
admet-184	208	51	above	above	ADP
admet-184	208	52	mentioned	mention	VERB
admet-184	208	53	absorption	absorption	NOUN
admet-184	208	54	enhancers	enhancer	NOUN
admet-184	208	55	shows	show	VERB
admet-184	208	56	rapid	rapid	ADJ
admet-184	208	57	delivery	delivery	NOUN
admet-184	208	58	of	of	ADP
admet-184	208	59	insulin	insulin	NOUN
admet-184	208	60	to	to	ADP
admet-184	208	61	the	the	DET
admet-184	208	62	serum	serum	NOUN
admet-184	209	1	[	[	X
admet-184	209	2	58,88	58,88	NOUN
admet-184	209	3	]	]	PUNCT
admet-184	209	4	.	.	PUNCT
admet-184	210	1	in	in	ADP
admet-184	210	2	addition	addition	NOUN
admet-184	210	3	,	,	PUNCT
admet-184	210	4	comparative	comparative	ADJ
admet-184	210	5	studies	study	NOUN
admet-184	210	6	are	be	AUX
admet-184	210	7	needed	need	VERB
admet-184	210	8	to	to	PART
admet-184	210	9	resolve	resolve	VERB
admet-184	210	10	the	the	DET
admet-184	210	11	mechanisms	mechanism	NOUN
admet-184	210	12	needed	need	VERB
admet-184	210	13	to	to	PART
admet-184	210	14	target	target	VERB
admet-184	210	15	insulin	insulin	NOUN
admet-184	210	16	or	or	CCONJ
admet-184	210	17	other	other	ADJ
admet-184	210	18	biopharmaceuticals	biopharmaceutical	NOUN
admet-184	210	19	either	either	CCONJ
admet-184	210	20	to	to	ADP
admet-184	210	21	the	the	DET
admet-184	210	22	periphery	periphery	NOUN
admet-184	210	23	or	or	CCONJ
admet-184	210	24	to	to	ADP
admet-184	210	25	the	the	DET
admet-184	210	26	brain	brain	NOUN
admet-184	210	27	.	.	PUNCT
admet-184	211	1	for	for	ADP
admet-184	211	2	intranasal	intranasal	ADJ
admet-184	211	3	insulin	insulin	NOUN
admet-184	211	4	that	that	PRON
admet-184	211	5	includes	include	VERB
admet-184	211	6	insulin	insulin	NOUN
admet-184	211	7	and	and	CCONJ
admet-184	211	8	glucose	glucose	NOUN
admet-184	211	9	levels	level	NOUN
admet-184	211	10	in	in	ADP
admet-184	211	11	serum	serum	NOUN
admet-184	211	12	and	and	CCONJ
admet-184	211	13	csf	csf	ADJ
admet-184	211	14	to	to	PART
admet-184	211	15	calculate	calculate	VERB
admet-184	211	16	pk	pk	PROPN
admet-184	211	17	-	-	PUNCT
admet-184	211	18	pd	pd	NOUN
admet-184	211	19	relations	relation	NOUN
admet-184	211	20	.	.	PUNCT
admet-184	212	1	the	the	DET
admet-184	212	2	bioavailability	bioavailability	NOUN
admet-184	212	3	and	and	CCONJ
admet-184	212	4	steady	steady	ADJ
admet-184	212	5	-	-	PUNCT
admet-184	212	6	state	state	NOUN
admet-184	212	7	kinetics	kinetic	NOUN
admet-184	212	8	of	of	ADP
admet-184	212	9	intranasal	intranasal	ADJ
admet-184	212	10	insulin	insulin	NOUN
admet-184	212	11	administered	administer	VERB
admet-184	212	12	over	over	ADP
admet-184	212	13	3	3	NUM
admet-184	212	14	weeks	week	NOUN
admet-184	212	15	to	to	ADP
admet-184	212	16	4	4	NUM
admet-184	212	17	months	month	NOUN
admet-184	212	18	has	have	AUX
admet-184	212	19	hardly	hardly	ADV
admet-184	212	20	been	be	AUX
admet-184	212	21	evaluated	evaluate	VERB
admet-184	212	22	.	.	PUNCT
admet-184	213	1	for	for	ADP
admet-184	213	2	a	a	DET
admet-184	213	3	convincing	convincing	ADJ
admet-184	213	4	safety	safety	NOUN
admet-184	213	5	profile	profile	NOUN
admet-184	213	6	this	this	DET
admet-184	213	7	data	datum	NOUN
admet-184	213	8	should	should	AUX
admet-184	213	9	be	be	AUX
admet-184	213	10	provided	provide	VERB
admet-184	213	11	.	.	PUNCT
admet-184	214	1	in	in	ADP
admet-184	214	2	addition	addition	NOUN
admet-184	214	3	,	,	PUNCT
admet-184	214	4	safety	safety	NOUN
admet-184	214	5	aspects	aspect	NOUN
admet-184	214	6	and	and	CCONJ
admet-184	214	7	adverse	adverse	ADJ
admet-184	214	8	events	event	NOUN
admet-184	214	9	like	like	ADP
admet-184	214	10	hypoglycaemia	hypoglycaemia	NOUN
admet-184	214	11	or	or	CCONJ
admet-184	214	12	dyslipidaemia	dyslipidaemia	NOUN
admet-184	214	13	should	should	AUX
admet-184	214	14	be	be	AUX
admet-184	214	15	adequately	adequately	ADV
admet-184	214	16	discussed	discuss	VERB
admet-184	214	17	in	in	ADP
admet-184	214	18	the	the	DET
admet-184	214	19	light	light	NOUN
admet-184	214	20	of	of	ADP
admet-184	214	21	a	a	DET
admet-184	214	22	chronic	chronic	ADJ
admet-184	214	23	treatment	treatment	NOUN
admet-184	214	24	.	.	PUNCT
admet-184	215	1	an	an	DET
admet-184	215	2	excess	excess	NOUN
admet-184	215	3	of	of	ADP
admet-184	215	4	insulin	insulin	NOUN
admet-184	215	5	that	that	PRON
admet-184	215	6	is	be	AUX
admet-184	215	7	distributed	distribute	VERB
admet-184	215	8	to	to	ADP
admet-184	215	9	the	the	DET
admet-184	215	10	vasculature	vasculature	NOUN
admet-184	215	11	might	might	AUX
admet-184	215	12	mediate	mediate	VERB
admet-184	215	13	such	such	ADJ
admet-184	215	14	adverse	adverse	ADJ
admet-184	215	15	events	event	NOUN
admet-184	215	16	.	.	PUNCT
admet-184	216	1	admet	admet	PROPN
admet-184	216	2	&	&	CCONJ
admet-184	216	3	dmpk	dmpk	PROPN
admet-184	216	4	3(3	3(3	NUM
admet-184	216	5	)	)	PUNCT
admet-184	216	6	(	(	PUNCT
admet-184	216	7	2015	2015	NUM
admet-184	216	8	)	)	PUNCT
admet-184	216	9	190	190	NUM
admet-184	216	10	-	-	SYM
admet-184	216	11	202	202	NUM
admet-184	216	12	intranasal	intranasal	ADJ
admet-184	216	13	insulin	insulin	NOUN
admet-184	216	14	as	as	ADP
admet-184	216	15	hope	hope	NOUN
admet-184	216	16	for	for	ADP
admet-184	216	17	ad	ad	NOUN
admet-184	216	18	?	?	PUNCT
admet-184	217	1	doi	doi	NOUN
admet-184	217	2	:	:	PUNCT
admet-184	217	3	10.5599	10.5599	NUM
admet-184	217	4	/	/	SYM
admet-184	217	5	admet.3.3.184	admet.3.3.184	NUM
admet-184	217	6	199	199	NUM
admet-184	217	7	though	though	ADV
admet-184	217	8	,	,	PUNCT
admet-184	217	9	any	any	DET
admet-184	217	10	ad	ad	NOUN
admet-184	217	11	study	study	NOUN
admet-184	217	12	that	that	PRON
admet-184	217	13	does	do	AUX
admet-184	217	14	not	not	PART
admet-184	217	15	fail	fail	VERB
admet-184	217	16	causes	cause	VERB
admet-184	217	17	euphoria	euphoria	NOUN
admet-184	217	18	,	,	PUNCT
admet-184	217	19	the	the	DET
admet-184	217	20	use	use	NOUN
admet-184	217	21	and	and	CCONJ
admet-184	217	22	the	the	DET
admet-184	217	23	transport	transport	NOUN
admet-184	217	24	mechanism	mechanism	NOUN
admet-184	217	25	of	of	ADP
admet-184	217	26	intranasal	intranasal	ADJ
admet-184	217	27	insulin	insulin	NOUN
admet-184	217	28	with	with	ADP
admet-184	217	29	and	and	CCONJ
admet-184	217	30	without	without	ADP
admet-184	217	31	additives	additive	NOUN
admet-184	217	32	needs	need	VERB
admet-184	217	33	to	to	PART
admet-184	217	34	be	be	AUX
admet-184	217	35	analysed	analyse	VERB
admet-184	217	36	very	very	ADV
admet-184	217	37	tightly	tightly	ADV
admet-184	217	38	and	and	CCONJ
admet-184	217	39	discussed	discuss	VERB
admet-184	217	40	more	more	ADV
admet-184	217	41	critically	critically	ADV
admet-184	217	42	in	in	ADP
admet-184	217	43	relation	relation	NOUN
admet-184	217	44	to	to	ADP
admet-184	217	45	its	its	PRON
admet-184	217	46	safety	safety	NOUN
admet-184	217	47	profile	profile	NOUN
admet-184	217	48	.	.	PUNCT
admet-184	218	1	the	the	DET
admet-184	218	2	number	number	NOUN
admet-184	218	3	of	of	ADP
admet-184	218	4	ad	ad	NOUN
admet-184	218	5	cases	case	NOUN
admet-184	218	6	increases	increase	VERB
admet-184	218	7	with	with	ADP
admet-184	218	8	the	the	DET
admet-184	218	9	demographic	demographic	ADJ
admet-184	218	10	change	change	NOUN
admet-184	218	11	and	and	CCONJ
admet-184	218	12	we	we	PRON
admet-184	218	13	need	need	VERB
admet-184	218	14	to	to	PART
admet-184	218	15	act	act	VERB
admet-184	218	16	now	now	ADV
admet-184	218	17	.	.	PUNCT
admet-184	219	1	future	future	ADJ
admet-184	219	2	ad	ad	NOUN
admet-184	219	3	patients	patient	NOUN
admet-184	219	4	are	be	AUX
admet-184	219	5	dependent	dependent	ADJ
admet-184	219	6	on	on	ADP
admet-184	219	7	our	our	PRON
admet-184	219	8	analytical	analytical	ADJ
admet-184	219	9	knowledge	knowledge	NOUN
admet-184	219	10	,	,	PUNCT
admet-184	219	11	pharmaceutical	pharmaceutical	NOUN
admet-184	219	12	expertise	expertise	NOUN
admet-184	219	13	and	and	CCONJ
admet-184	219	14	scientific	scientific	ADJ
admet-184	219	15	creativity	creativity	NOUN
admet-184	219	16	to	to	PART
admet-184	219	17	develop	develop	VERB
admet-184	219	18	candidates	candidate	NOUN
admet-184	219	19	like	like	ADP
admet-184	219	20	n2b	n2b	PROPN
admet-184	219	21	delivered	deliver	VERB
admet-184	219	22	insulin	insulin	NOUN
admet-184	219	23	to	to	ADP
admet-184	219	24	a	a	DET
admet-184	219	25	safe	safe	ADJ
admet-184	219	26	,	,	PUNCT
admet-184	219	27	suitable	suitable	ADJ
admet-184	219	28	and	and	CCONJ
admet-184	219	29	validated	validated	ADJ
admet-184	219	30	drug	drug	NOUN
admet-184	219	31	therapy	therapy	NOUN
admet-184	219	32	.	.	PUNCT
admet-184	220	1	a	a	DET
admet-184	220	2	recent	recent	ADJ
admet-184	220	3	empirical	empirical	ADJ
admet-184	220	4	analysis	analysis	NOUN
admet-184	220	5	uncovered	uncover	VERB
admet-184	220	6	the	the	DET
admet-184	220	7	massive	massive	ADJ
admet-184	220	8	lack	lack	NOUN
admet-184	220	9	of	of	ADP
admet-184	220	10	quantitative	quantitative	ADJ
admet-184	220	11	data	datum	NOUN
admet-184	220	12	in	in	ADP
admet-184	220	13	published	publish	VERB
admet-184	220	14	n2b	n2b	NOUN
admet-184	220	15	scientific	scientific	ADJ
admet-184	220	16	publications	publication	NOUN
admet-184	220	17	:	:	PUNCT
admet-184	220	18	only	only	ADV
admet-184	220	19	3	3	NUM
admet-184	220	20	%	%	NOUN
admet-184	220	21	of	of	ADP
admet-184	220	22	the	the	DET
admet-184	220	23	studies	study	NOUN
admet-184	220	24	determine	determine	VERB
admet-184	220	25	and	and	CCONJ
admet-184	220	26	publish	publish	VERB
admet-184	220	27	quantitative	quantitative	ADJ
admet-184	220	28	data	datum	NOUN
admet-184	220	29	like	like	ADP
admet-184	220	30	bioavailability	bioavailability	NOUN
admet-184	220	31	or	or	CCONJ
admet-184	220	32	similar	similar	ADJ
admet-184	220	33	[	[	X
admet-184	220	34	89	89	NUM
admet-184	220	35	]	]	PUNCT
admet-184	220	36	.	.	PUNCT
admet-184	221	1	however	however	ADV
admet-184	221	2	,	,	PUNCT
admet-184	221	3	the	the	DET
admet-184	221	4	development	development	NOUN
admet-184	221	5	of	of	ADP
admet-184	221	6	a	a	DET
admet-184	221	7	successful	successful	ADJ
admet-184	221	8	n2b	n2b	NOUN
admet-184	221	9	technique	technique	NOUN
admet-184	221	10	requires	require	VERB
admet-184	221	11	quantitative	quantitative	ADJ
admet-184	221	12	pk	pk	NOUN
admet-184	221	13	-	-	PUNCT
admet-184	221	14	pd	pd	NOUN
admet-184	221	15	data	datum	NOUN
admet-184	221	16	to	to	PART
admet-184	221	17	engineer	engineer	VERB
admet-184	221	18	a	a	DET
admet-184	221	19	safe	safe	ADJ
admet-184	221	20	and	and	CCONJ
admet-184	221	21	efficient	efficient	ADJ
admet-184	221	22	delivering	delivering	NOUN
admet-184	221	23	strategy	strategy	NOUN
admet-184	221	24	.	.	PUNCT
admet-184	222	1	acknowledgements	acknowledgement	NOUN
admet-184	222	2	:	:	PUNCT
admet-184	222	3	this	this	DET
admet-184	222	4	analysis	analysis	NOUN
admet-184	222	5	was	be	AUX
admet-184	222	6	supported	support	VERB
admet-184	222	7	by	by	ADP
admet-184	222	8	ulm	ulm	NOUN
admet-184	222	9	and	and	CCONJ
admet-184	222	10	biberach	biberach	VERB
admet-184	222	11	joint	joint	ADJ
admet-184	222	12	graduate	graduate	NOUN
admet-184	222	13	school	school	NOUN
admet-184	222	14	in	in	ADP
admet-184	222	15	pharmaceutical	pharmaceutical	NOUN
admet-184	222	16	biotechnology	biotechnology	NOUN
admet-184	222	17	funded	fund	VERB
admet-184	222	18	by	by	ADP
admet-184	222	19	the	the	DET
admet-184	222	20	baden	baden	PROPN
admet-184	222	21	-	-	PUNCT
admet-184	222	22	württemberg	württemberg	PROPN
admet-184	222	23	state	state	PROPN
admet-184	222	24	ministry	ministry	PROPN
admet-184	222	25	of	of	ADP
admet-184	222	26	science	science	PROPN
admet-184	222	27	,	,	PUNCT
admet-184	222	28	research	research	NOUN
admet-184	222	29	and	and	CCONJ
admet-184	222	30	arts	art	NOUN
admet-184	222	31	,	,	PUNCT
admet-184	222	32	from	from	ADP
admet-184	222	33	the	the	DET
admet-184	222	34	graduate	graduate	NOUN
admet-184	222	35	school	school	NOUN
admet-184	222	36	“	"	PUNCT
admet-184	222	37	molecular	molecular	ADJ
admet-184	222	38	medicine	medicine	NOUN
admet-184	222	39	”	"	PUNCT
admet-184	222	40	of	of	ADP
admet-184	222	41	ulm	ulm	PROPN
admet-184	222	42	university	university	PROPN
admet-184	222	43	(	(	PUNCT
admet-184	222	44	to	to	PART
admet-184	222	45	martina	martina	VERB
admet-184	222	46	stützle	stützle	NOUN
admet-184	222	47	)	)	PUNCT
admet-184	222	48	and	and	CCONJ
admet-184	222	49	from	from	ADP
admet-184	222	50	a	a	DET
admet-184	222	51	fellowship	fellowship	NOUN
admet-184	222	52	from	from	ADP
admet-184	222	53	the	the	DET
admet-184	222	54	stiftung	stiftung	PROPN
admet-184	222	55	der	der	PROPN
admet-184	222	56	deutschen	deutschen	PROPN
admet-184	222	57	wirtschaft	wirtschaft	PROPN
admet-184	222	58	(	(	PUNCT
admet-184	222	59	to	to	ADP
admet-184	222	60	johannes	johannes	PROPN
admet-184	222	61	flamm	flamm	PROPN
admet-184	222	62	)	)	PUNCT
admet-184	222	63	.	.	PUNCT
admet-184	223	1	special	special	ADJ
admet-184	223	2	thanks	thank	NOUN
admet-184	223	3	to	to	ADP
admet-184	223	4	anne	anne	PROPN
admet-184	223	5	-	-	PUNCT
admet-184	223	6	sophie	sophie	PROPN
admet-184	223	7	and	and	CCONJ
admet-184	223	8	jürgen	jürgen	PROPN
admet-184	223	9	zimmermann	zimmermann	PROPN
admet-184	223	10	for	for	ADP
admet-184	223	11	support	support	NOUN
admet-184	223	12	and	and	CCONJ
admet-184	223	13	help	help	VERB
admet-184	223	14	with	with	ADP
admet-184	223	15	the	the	DET
admet-184	223	16	manuscript	manuscript	NOUN
admet-184	223	17	.	.	PUNCT
admet-184	224	1	references	reference	NOUN
admet-184	224	2	[	[	X
admet-184	224	3	1	1	NUM
admet-184	224	4	]	]	X
admet-184	224	5	world_health_organization_and_alzheimer’s_disease_international	world_health_organization_and_alzheimer’s_disease_international	PROPN
admet-184	224	6	,	,	PUNCT
admet-184	224	7	dementia	dementia	NOUN
admet-184	224	8	:	:	PUNCT
admet-184	224	9	a	a	DET
admet-184	224	10	public	public	ADJ
admet-184	224	11	health	health	NOUN
admet-184	224	12	priority	priority	NOUN
admet-184	224	13	,	,	PUNCT
admet-184	224	14	2012	2012	NUM
admet-184	224	15	.	.	PUNCT
admet-184	225	1	[	[	X
admet-184	225	2	2	2	NUM
admet-184	225	3	]	]	PUNCT
admet-184	225	4	neurological	neurological	ADJ
admet-184	225	5	disorders	disorder	NOUN
admet-184	225	6	:	:	PUNCT
admet-184	225	7	public	public	ADJ
admet-184	225	8	health	health	NOUN
admet-184	225	9	challenges	challenge	NOUN
admet-184	225	10	,	,	PUNCT
admet-184	225	11	http://www.who.int/mental_health/neurology/neurodiso/en/index.html	http://www.who.int/mental_health/neurology/neurodiso/en/index.html	X
admet-184	225	12	.	.	PUNCT
admet-184	226	1	[	[	X
admet-184	226	2	3	3	X
admet-184	226	3	]	]	X
admet-184	226	4	j.	j.	PROPN
admet-184	226	5	moreth	moreth	PROPN
admet-184	226	6	,	,	PUNCT
admet-184	226	7	c.	c.	PROPN
admet-184	226	8	mavoungou	mavoungou	PROPN
admet-184	226	9	,	,	PUNCT
admet-184	226	10	k.	k.	PROPN
admet-184	226	11	schindowski	schindowski	PROPN
admet-184	226	12	,	,	PUNCT
admet-184	226	13	immunity	immunity	NOUN
admet-184	226	14	&	&	CCONJ
admet-184	226	15	ageing	age	VERB
admet-184	226	16	10:18	10:18	NUM
admet-184	226	17	(	(	PUNCT
admet-184	226	18	2013	2013	NUM
admet-184	226	19	)	)	PUNCT
admet-184	226	20	.	.	PUNCT
admet-184	227	1	[	[	X
admet-184	227	2	4	4	NUM
admet-184	227	3	]	]	X
admet-184	227	4	c.	c.	NOUN
admet-184	227	5	schindowski	schindowski	PROPN
admet-184	227	6	,	,	PUNCT
admet-184	227	7	j.	j.	PROPN
admet-184	227	8	zimmermann	zimmermann	PROPN
admet-184	227	9	,	,	PUNCT
admet-184	227	10	k.	k.	PROPN
admet-184	227	11	schindowski	schindowski	PROPN
admet-184	227	12	,	,	PUNCT
admet-184	227	13	degenerative	degenerative	ADJ
admet-184	227	14	neurological	neurological	ADJ
admet-184	227	15	&	&	CCONJ
admet-184	227	16	neuromuscular	neuromuscular	ADJ
admet-184	227	17	disease	disease	NOUN
admet-184	227	18	4	4	NUM
admet-184	227	19	(	(	PUNCT
admet-184	227	20	2014	2014	NUM
admet-184	227	21	)	)	PUNCT
admet-184	227	22	121	121	NUM
admet-184	227	23	-	-	SYM
admet-184	227	24	130	130	NUM
admet-184	227	25	.	.	PUNCT
admet-184	228	1	[	[	X
admet-184	228	2	5	5	NUM
admet-184	228	3	]	]	X
admet-184	228	4	t.s	t.s	PROPN
admet-184	228	5	.	.	PROPN
admet-184	228	6	reese	reese	PROPN
admet-184	228	7	,	,	PUNCT
admet-184	228	8	m.j	m.j	PROPN
admet-184	228	9	.	.	PROPN
admet-184	228	10	karnovsky	karnovsky	PROPN
admet-184	228	11	,	,	PUNCT
admet-184	228	12	the	the	DET
admet-184	228	13	journal	journal	NOUN
admet-184	228	14	of	of	ADP
admet-184	228	15	cell	cell	NOUN
admet-184	228	16	biology	biology	NOUN
admet-184	228	17	34	34	NUM
admet-184	228	18	(	(	PUNCT
admet-184	228	19	1967	1967	NUM
admet-184	228	20	)	)	PUNCT
admet-184	228	21	207	207	NUM
admet-184	228	22	-	-	SYM
admet-184	228	23	217	217	NUM
admet-184	228	24	.	.	PUNCT
admet-184	229	1	[	[	X
admet-184	229	2	6	6	NUM
admet-184	229	3	]	]	X
admet-184	229	4	w.a	w.a	PROPN
admet-184	229	5	.	.	PROPN
admet-184	229	6	banks	bank	NOUN
admet-184	229	7	,	,	PUNCT
admet-184	229	8	bmc	bmc	ADJ
admet-184	229	9	neurology	neurology	NOUN
admet-184	229	10	9	9	NUM
admet-184	229	11	suppl	suppl	NOUN
admet-184	229	12	1	1	NUM
admet-184	229	13	(	(	PUNCT
admet-184	229	14	2009	2009	NUM
admet-184	229	15	)	)	PUNCT
admet-184	229	16	s3	s3	PROPN
admet-184	229	17	.	.	PUNCT
admet-184	230	1	[	[	X
admet-184	230	2	7	7	NUM
admet-184	230	3	]	]	X
admet-184	230	4	a.p	a.p	PROPN
admet-184	230	5	.	.	PROPN
admet-184	230	6	dick	dick	PROPN
admet-184	230	7	,	,	PUNCT
admet-184	230	8	s.i	s.i	PROPN
admet-184	230	9	.	.	PROPN
admet-184	230	10	harik	harik	PROPN
admet-184	230	11	,	,	PUNCT
admet-184	230	12	a.	a.	NOUN
admet-184	230	13	klip	klip	PROPN
admet-184	230	14	,	,	PUNCT
admet-184	230	15	d.m	d.m	PROPN
admet-184	230	16	.	.	PROPN
admet-184	230	17	walker	walker	PROPN
admet-184	230	18	,	,	PUNCT
admet-184	230	19	proceedings	proceeding	NOUN
admet-184	230	20	of	of	ADP
admet-184	230	21	the	the	DET
admet-184	230	22	national	national	PROPN
admet-184	230	23	academy	academy	PROPN
admet-184	230	24	of	of	ADP
admet-184	230	25	sciences	sciences	PROPN
admet-184	230	26	of	of	ADP
admet-184	230	27	the	the	DET
admet-184	230	28	united	united	PROPN
admet-184	230	29	states	states	PROPN
admet-184	230	30	of	of	ADP
admet-184	230	31	america	america	PROPN
admet-184	230	32	81	81	NUM
admet-184	230	33	(	(	PUNCT
admet-184	230	34	1984	1984	NUM
admet-184	230	35	)	)	PUNCT
admet-184	230	36	7233	7233	NUM
admet-184	230	37	-	-	SYM
admet-184	230	38	7237	7237	NUM
admet-184	230	39	.	.	PUNCT
admet-184	231	1	[	[	X
admet-184	231	2	8	8	NUM
admet-184	231	3	]	]	X
admet-184	231	4	w.a	w.a	PROPN
admet-184	231	5	.	.	PROPN
admet-184	231	6	jefferies	jefferies	PROPN
admet-184	231	7	,	,	PUNCT
admet-184	231	8	m.r	m.r	PROPN
admet-184	231	9	.	.	PROPN
admet-184	231	10	brandon	brandon	PROPN
admet-184	231	11	,	,	PUNCT
admet-184	231	12	s.v	s.v	PROPN
admet-184	231	13	.	.	PROPN
admet-184	231	14	hunt	hunt	PROPN
admet-184	231	15	,	,	PUNCT
admet-184	231	16	a.f	a.f	PROPN
admet-184	231	17	.	.	PROPN
admet-184	231	18	williams	williams	PROPN
admet-184	231	19	,	,	PUNCT
admet-184	231	20	k.c	k.c	PROPN
admet-184	231	21	.	.	PROPN
admet-184	231	22	gatter	gatter	PROPN
admet-184	231	23	,	,	PUNCT
admet-184	231	24	d.y	d.y	PROPN
admet-184	231	25	.	.	PROPN
admet-184	231	26	mason	mason	PROPN
admet-184	231	27	,	,	PUNCT
admet-184	231	28	nature	nature	NOUN
admet-184	231	29	312	312	NUM
admet-184	231	30	(	(	PUNCT
admet-184	231	31	1984	1984	NUM
admet-184	231	32	)	)	PUNCT
admet-184	231	33	162	162	NUM
admet-184	231	34	-	-	SYM
admet-184	231	35	163	163	NUM
admet-184	231	36	.	.	PUNCT
admet-184	232	1	[	[	X
admet-184	232	2	9	9	NUM
admet-184	232	3	]	]	X
admet-184	232	4	w.a	w.a	PROPN
admet-184	232	5	.	.	PROPN
admet-184	232	6	banks	bank	NOUN
admet-184	232	7	,	,	PUNCT
admet-184	232	8	regulatory	regulatory	ADJ
admet-184	232	9	peptides	peptide	NOUN
admet-184	232	10	149	149	NUM
admet-184	232	11	(	(	PUNCT
admet-184	232	12	2008	2008	NUM
admet-184	232	13	)	)	PUNCT
admet-184	232	14	11	11	NUM
admet-184	232	15	-	-	SYM
admet-184	232	16	14	14	NUM
admet-184	232	17	.	.	PUNCT
admet-184	233	1	[	[	X
admet-184	233	2	10	10	NUM
admet-184	233	3	]	]	X
admet-184	233	4	d.j	d.j	PROPN
admet-184	233	5	.	.	PROPN
admet-184	233	6	begley	begley	PROPN
admet-184	233	7	,	,	PUNCT
admet-184	233	8	pharmacology	pharmacology	NOUN
admet-184	233	9	&	&	CCONJ
admet-184	233	10	therapeutics	therapeutic	NOUN
admet-184	233	11	104	104	NUM
admet-184	233	12	(	(	PUNCT
admet-184	233	13	2004	2004	NUM
admet-184	233	14	)	)	PUNCT
admet-184	233	15	29	29	NUM
admet-184	233	16	-	-	SYM
admet-184	233	17	45	45	NUM
admet-184	233	18	.	.	PUNCT
admet-184	234	1	[	[	X
admet-184	234	2	11	11	NUM
admet-184	234	3	]	]	PUNCT
admet-184	234	4	h.	h.	PROPN
admet-184	234	5	gensicke	gensicke	PROPN
admet-184	234	6	,	,	PUNCT
admet-184	234	7	d.	d.	PROPN
admet-184	234	8	leppert	leppert	PROPN
admet-184	234	9	,	,	PUNCT
admet-184	234	10	o.	o.	PROPN
admet-184	234	11	yaldizli	yaldizli	PROPN
admet-184	234	12	,	,	PUNCT
admet-184	234	13	r.l	r.l	PROPN
admet-184	234	14	.	.	PROPN
admet-184	234	15	lindberg	lindberg	PROPN
admet-184	234	16	,	,	PUNCT
admet-184	234	17	m.	m.	NOUN
admet-184	234	18	mehling	mehling	PROPN
admet-184	234	19	,	,	PUNCT
admet-184	234	20	l.	l.	PROPN
admet-184	234	21	kappos	kappos	PROPN
admet-184	234	22	,	,	PUNCT
admet-184	234	23	j.	j.	PROPN
admet-184	234	24	kuhle	kuhle	PROPN
admet-184	234	25	,	,	PUNCT
admet-184	234	26	cns	cns	PROPN
admet-184	234	27	drugs	drug	NOUN
admet-184	234	28	26	26	NUM
admet-184	234	29	(	(	PUNCT
admet-184	234	30	2012	2012	NUM
admet-184	234	31	)	)	PUNCT
admet-184	234	32	11	11	NUM
admet-184	234	33	-	-	SYM
admet-184	234	34	37	37	NUM
admet-184	234	35	.	.	PUNCT
admet-184	235	1	[	[	X
admet-184	235	2	12	12	NUM
admet-184	235	3	]	]	X
admet-184	235	4	r.m	r.m	PROPN
admet-184	235	5	.	.	PROPN
admet-184	235	6	levy	levy	PROPN
admet-184	235	7	,	,	PUNCT
admet-184	235	8	d.	d.	PROPN
admet-184	235	9	salzman	salzman	PROPN
admet-184	235	10	,	,	PUNCT
admet-184	235	11	neurosurgical	neurosurgical	ADJ
admet-184	235	12	management	management	NOUN
admet-184	235	13	of	of	ADP
admet-184	235	14	pain	pain	NOUN
admet-184	235	15	,	,	PUNCT
admet-184	235	16	(	(	PUNCT
admet-184	235	17	eds	ed	NOUN
admet-184	235	18	.	.	PUNCT
admet-184	236	1	r.b	r.b	PROPN
admet-184	236	2	.	.	PROPN
admet-184	236	3	north	north	PROPN
admet-184	236	4	,	,	PUNCT
admet-184	236	5	r.m	r.m	PROPN
admet-184	236	6	.	.	PROPN
admet-184	236	7	levy	levy	PROPN
admet-184	236	8	)	)	PUNCT
admet-184	236	9	springer	springer	NOUN
admet-184	236	10	1997	1997	NUM
admet-184	236	11	,	,	PUNCT
admet-184	236	12	p.	p.	NOUN
admet-184	236	13	302	302	NUM
admet-184	236	14	-	-	SYM
admet-184	236	15	324	324	NUM
admet-184	236	16	.	.	PUNCT
admet-184	237	1	[	[	X
admet-184	237	2	13	13	NUM
admet-184	237	3	]	]	X
admet-184	237	4	t.j	t.j	PROPN
admet-184	237	5	.	.	PROPN
admet-184	237	6	lamer	lamer	PROPN
admet-184	237	7	,	,	PUNCT
admet-184	237	8	mayo	mayo	NOUN
admet-184	237	9	clinic	clinic	NOUN
admet-184	237	10	proceedings	proceeding	NOUN
admet-184	237	11	69	69	NUM
admet-184	237	12	(	(	PUNCT
admet-184	237	13	1994	1994	NUM
admet-184	237	14	)	)	PUNCT
admet-184	237	15	473	473	NUM
admet-184	237	16	-	-	SYM
admet-184	237	17	480	480	NUM
admet-184	237	18	.	.	PUNCT
admet-184	238	1	[	[	X
admet-184	238	2	14	14	NUM
admet-184	238	3	]	]	X
admet-184	238	4	r.	r.	PROPN
admet-184	238	5	gilmartin	gilmartin	PROPN
admet-184	238	6	,	,	PUNCT
admet-184	238	7	d.	d.	PROPN
admet-184	238	8	bruce	bruce	PROPN
admet-184	238	9	,	,	PUNCT
admet-184	238	10	b.b	b.b	PROPN
admet-184	238	11	.	.	PROPN
admet-184	238	12	storrs	storrs	PROPN
admet-184	238	13	,	,	PUNCT
admet-184	238	14	r.	r.	PROPN
admet-184	238	15	abbott	abbott	PROPN
admet-184	238	16	,	,	PUNCT
admet-184	238	17	l.	l.	PROPN
admet-184	238	18	krach	krach	PROPN
admet-184	238	19	,	,	PUNCT
admet-184	238	20	j.	j.	PROPN
admet-184	238	21	ward	ward	PROPN
admet-184	238	22	,	,	PUNCT
admet-184	238	23	k.	k.	PROPN
admet-184	238	24	bloom	bloom	PROPN
admet-184	238	25	,	,	PUNCT
admet-184	238	26	w.h	w.h	PROPN
admet-184	238	27	.	.	PROPN
admet-184	238	28	brooks	brooks	PROPN
admet-184	238	29	,	,	PUNCT
admet-184	238	30	d.l	d.l	PROPN
admet-184	238	31	.	.	PROPN
admet-184	238	32	johnson	johnson	PROPN
admet-184	238	33	,	,	PUNCT
admet-184	238	34	j.r	j.r	PROPN
admet-184	238	35	.	.	PROPN
admet-184	238	36	madsen	madsen	PROPN
admet-184	238	37	,	,	PUNCT
admet-184	238	38	j.f	j.f	PROPN
admet-184	238	39	.	.	PROPN
admet-184	238	40	mclaughlin	mclaughlin	PROPN
admet-184	238	41	,	,	PUNCT
admet-184	238	42	j.	j.	PROPN
admet-184	238	43	nadell	nadell	PROPN
admet-184	238	44	,	,	PUNCT
admet-184	238	45	journal	journal	NOUN
admet-184	238	46	of	of	ADP
admet-184	238	47	child	child	NOUN
admet-184	238	48	neurology	neurology	NOUN
admet-184	238	49	15	15	NUM
admet-184	238	50	(	(	PUNCT
admet-184	238	51	2000	2000	NUM
admet-184	238	52	)	)	PUNCT
admet-184	238	53	71	71	NUM
admet-184	238	54	-	-	SYM
admet-184	238	55	77	77	NUM
admet-184	238	56	.	.	PUNCT
admet-184	239	1	[	[	X
admet-184	239	2	15	15	NUM
admet-184	239	3	]	]	X
admet-184	239	4	s.	s.	PROPN
admet-184	239	5	sgouros	sgouros	PROPN
admet-184	239	6	,	,	PUNCT
admet-184	239	7	c.	c.	PROPN
admet-184	239	8	charalambides	charalambides	PROPN
admet-184	239	9	,	,	PUNCT
admet-184	239	10	p.	p.	NOUN
admet-184	239	11	matsota	matsota	NOUN
admet-184	239	12	,	,	PUNCT
admet-184	239	13	i.	i.	PROPN
admet-184	239	14	tsangaris	tsangaris	PROPN
admet-184	239	15	,	,	PUNCT
admet-184	239	16	g.	g.	PROPN
admet-184	239	17	kostopanagiotou	kostopanagiotou	PROPN
admet-184	239	18	,	,	PUNCT
admet-184	239	19	pediatric	pediatric	ADJ
admet-184	239	20	neurosurgery	neurosurgery	NOUN
admet-184	239	21	46	46	NUM
admet-184	239	22	(	(	PUNCT
admet-184	239	23	2010	2010	NUM
admet-184	239	24	)	)	PUNCT
admet-184	239	25	62	62	NUM
admet-184	239	26	-	-	SYM
admet-184	239	27	65	65	NUM
admet-184	239	28	.	.	PUNCT
admet-184	240	1	[	[	X
admet-184	240	2	16	16	NUM
admet-184	240	3	]	]	PUNCT
admet-184	240	4	p.	p.	NOUN
admet-184	240	5	maino	maino	PROPN
admet-184	240	6	,	,	PUNCT
admet-184	240	7	e.	e.	PROPN
admet-184	240	8	koetsier	koetsier	PROPN
admet-184	240	9	,	,	PUNCT
admet-184	240	10	r.s	r.s	PROPN
admet-184	240	11	.	.	PROPN
admet-184	240	12	perez	perez	PROPN
admet-184	240	13	,	,	PUNCT
admet-184	240	14	regional	regional	ADJ
admet-184	240	15	anesthesia	anesthesia	NOUN
admet-184	240	16	and	and	CCONJ
admet-184	240	17	pain	pain	NOUN
admet-184	240	18	medicine	medicine	NOUN
admet-184	240	19	39	39	NUM
admet-184	240	20	(	(	PUNCT
admet-184	240	21	2014	2014	NUM
admet-184	240	22	)	)	PUNCT
admet-184	240	23	434	434	NUM
admet-184	240	24	-	-	SYM
admet-184	240	25	437	437	NUM
admet-184	240	26	.	.	PUNCT
admet-184	241	1	http://www.who.int/mental_health/neurology/neurodiso/en/index.html	http://www.who.int/mental_health/neurology/neurodiso/en/index.html	PUNCT
admet-184	241	2	m.	m.	NOUN
admet-184	241	3	stützle	stützle	NOUN
admet-184	241	4	,	,	PUNCT
admet-184	241	5	j.	j.	PROPN
admet-184	241	6	flamm	flamm	PROPN
admet-184	241	7	,	,	PUNCT
admet-184	241	8	s.	s.	PROPN
admet-184	241	9	carle	carle	PROPN
admet-184	241	10	and	and	CCONJ
admet-184	241	11	k.	k.	PROPN
admet-184	241	12	schindowski	schindowski	PROPN
admet-184	241	13	admet	admet	PROPN
admet-184	241	14	&	&	CCONJ
admet-184	241	15	dmpk	dmpk	PROPN
admet-184	241	16	3(3	3(3	NUM
admet-184	241	17	)	)	PUNCT
admet-184	241	18	(	(	PUNCT
admet-184	241	19	2015	2015	NUM
admet-184	241	20	)	)	PUNCT
admet-184	241	21	190	190	NUM
admet-184	241	22	-	-	SYM
admet-184	241	23	202	202	NUM
admet-184	241	24	200	200	NUM
admet-184	242	1	[	[	SYM
admet-184	242	2	17	17	NUM
admet-184	242	3	]	]	X
admet-184	242	4	e.	e.	PROPN
admet-184	242	5	neuwelt	neuwelt	PROPN
admet-184	242	6	,	,	PUNCT
admet-184	242	7	n.j	n.j	PROPN
admet-184	242	8	.	.	PROPN
admet-184	242	9	abbott	abbott	PROPN
admet-184	242	10	,	,	PUNCT
admet-184	242	11	l.	l.	PROPN
admet-184	242	12	abrey	abrey	PROPN
admet-184	242	13	,	,	PUNCT
admet-184	242	14	w.a	w.a	PROPN
admet-184	242	15	.	.	PROPN
admet-184	242	16	banks	banks	PROPN
admet-184	242	17	,	,	PUNCT
admet-184	242	18	b.	b.	PROPN
admet-184	242	19	blakley	blakley	PROPN
admet-184	242	20	,	,	PUNCT
admet-184	242	21	t.	t.	PROPN
admet-184	242	22	davis	davis	PROPN
admet-184	242	23	,	,	PUNCT
admet-184	242	24	b.	b.	PROPN
admet-184	242	25	engelhardt	engelhardt	PROPN
admet-184	242	26	,	,	PUNCT
admet-184	242	27	p.	p.	NOUN
admet-184	242	28	grammas	grammas	PROPN
admet-184	242	29	,	,	PUNCT
admet-184	242	30	m.	m.	NOUN
admet-184	242	31	nedergaard	nedergaard	PROPN
admet-184	242	32	,	,	PUNCT
admet-184	242	33	j.	j.	PROPN
admet-184	242	34	nutt	nutt	PROPN
admet-184	242	35	,	,	PUNCT
admet-184	242	36	w.	w.	PROPN
admet-184	242	37	pardridge	pardridge	PROPN
admet-184	242	38	,	,	PUNCT
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admet-184	242	40	.	.	PROPN
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admet-184	242	42	,	,	PUNCT
admet-184	242	43	q.	q.	PROPN
admet-184	242	44	smith	smith	PROPN
admet-184	242	45	,	,	PUNCT
admet-184	242	46	l.r	l.r	PROPN
admet-184	242	47	.	.	PROPN
admet-184	242	48	drewes	drewes	PROPN
admet-184	242	49	,	,	PUNCT
admet-184	242	50	the	the	DET
admet-184	242	51	lancet	lancet	NOUN
admet-184	242	52	neurology	neurology	NOUN
admet-184	242	53	7	7	NUM
admet-184	242	54	(	(	PUNCT
admet-184	242	55	2008	2008	NUM
admet-184	242	56	)	)	PUNCT
admet-184	242	57	84	84	NUM
admet-184	242	58	-	-	SYM
admet-184	242	59	96	96	NUM
admet-184	242	60	.	.	PUNCT
admet-184	243	1	[	[	X
admet-184	243	2	18	18	NUM
admet-184	243	3	]	]	X
admet-184	243	4	j.j	j.j	PROPN
admet-184	243	5	.	.	PROPN
admet-184	243	6	lochhead	lochhead	PROPN
admet-184	243	7	,	,	PUNCT
admet-184	243	8	r.g	r.g	PROPN
admet-184	243	9	.	.	PROPN
admet-184	243	10	thorne	thorne	PROPN
admet-184	243	11	,	,	PUNCT
admet-184	243	12	advanced	advanced	ADJ
admet-184	243	13	drug	drug	NOUN
admet-184	243	14	delivery	delivery	NOUN
admet-184	243	15	reviews	review	VERB
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admet-184	243	17	(	(	PUNCT
admet-184	243	18	2012	2012	NUM
admet-184	243	19	)	)	PUNCT
admet-184	243	20	614	614	NUM
admet-184	243	21	-	-	SYM
admet-184	243	22	628	628	NUM
admet-184	243	23	.	.	PUNCT
admet-184	244	1	[	[	X
admet-184	244	2	19	19	NUM
admet-184	244	3	]	]	X
admet-184	244	4	r.l	r.l	PROPN
admet-184	244	5	.	.	PROPN
admet-184	244	6	doty	doty	PROPN
admet-184	244	7	,	,	PUNCT
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admet-184	244	10	olfaction	olfaction	NOUN
admet-184	244	11	and	and	CCONJ
admet-184	244	12	gustation	gustation	NOUN
admet-184	244	13	,	,	PUNCT
admet-184	244	14	third	third	ADJ
admet-184	244	15	edition	edition	NOUN
admet-184	244	16	.	.	PUNCT
admet-184	245	1	john	john	PROPN
admet-184	245	2	wiley	wiley	PROPN
admet-184	245	3	&	&	CCONJ
admet-184	245	4	sons	sons	PROPN
admet-184	245	5	inc	inc	PROPN
admet-184	245	6	.	.	PROPN
admet-184	245	7	,	,	PUNCT
admet-184	245	8	hoboken	hoboken	PROPN
admet-184	245	9	,	,	PUNCT
admet-184	245	10	new	new	PROPN
admet-184	245	11	jersey	jersey	PROPN
admet-184	245	12	,	,	PUNCT
admet-184	245	13	2015	2015	NUM
admet-184	245	14	.	.	PUNCT
admet-184	246	1	[	[	X
admet-184	246	2	20	20	NUM
admet-184	246	3	]	]	PUNCT
admet-184	246	4	h.	h.	PROPN
admet-184	246	5	kiyono	kiyono	PROPN
admet-184	246	6	,	,	PUNCT
admet-184	246	7	s.	s.	PROPN
admet-184	246	8	fukuyama	fukuyama	PROPN
admet-184	246	9	,	,	PUNCT
admet-184	246	10	nature	nature	NOUN
admet-184	246	11	reviews	review	VERB
admet-184	246	12	immunology	immunology	NOUN
admet-184	246	13	4	4	NUM
admet-184	246	14	(	(	PUNCT
admet-184	246	15	2004	2004	NUM
admet-184	246	16	)	)	PUNCT
admet-184	246	17	699	699	NUM
admet-184	246	18	-	-	SYM
admet-184	246	19	710	710	NUM
admet-184	246	20	.	.	PUNCT
admet-184	247	1	[	[	X
admet-184	247	2	21	21	NUM
admet-184	247	3	]	]	X
admet-184	247	4	j.r	j.r	PROPN
admet-184	247	5	.	.	PROPN
admet-184	247	6	harkema	harkema	PROPN
admet-184	247	7	,	,	PUNCT
admet-184	247	8	s.a	s.a	PROPN
admet-184	247	9	.	.	PROPN
admet-184	247	10	carey	carey	PROPN
admet-184	247	11	,	,	PUNCT
admet-184	247	12	j.g	j.g	PROPN
admet-184	247	13	.	.	PROPN
admet-184	247	14	wagner	wagner	PROPN
admet-184	247	15	,	,	PUNCT
admet-184	247	16	toxicologic	toxicologic	ADJ
admet-184	247	17	pathology	pathology	NOUN
admet-184	247	18	34	34	NUM
admet-184	247	19	(	(	PUNCT
admet-184	247	20	2006	2006	NUM
admet-184	247	21	)	)	PUNCT
admet-184	247	22	252	252	NUM
admet-184	247	23	-	-	SYM
admet-184	247	24	269	269	NUM
admet-184	247	25	.	.	PUNCT
admet-184	248	1	[	[	X
admet-184	248	2	22	22	NUM
admet-184	248	3	]	]	X
admet-184	248	4	t.e	t.e	PROPN
admet-184	248	5	.	.	PROPN
admet-184	248	6	finger	finger	PROPN
admet-184	248	7	,	,	PUNCT
admet-184	248	8	v.l	v.l	PROPN
admet-184	248	9	.	.	PROPN
admet-184	248	10	st	st	PROPN
admet-184	248	11	jeor	jeor	PROPN
admet-184	248	12	,	,	PUNCT
admet-184	248	13	j.c	j.c	PROPN
admet-184	248	14	.	.	PROPN
admet-184	248	15	kinnamon	kinnamon	PROPN
admet-184	248	16	,	,	PUNCT
admet-184	248	17	w.l	w.l	PROPN
admet-184	248	18	.	.	PROPN
admet-184	248	19	silver	silver	PROPN
admet-184	248	20	,	,	PUNCT
admet-184	248	21	the	the	DET
admet-184	248	22	journal	journal	NOUN
admet-184	248	23	of	of	ADP
admet-184	248	24	comparative	comparative	ADJ
admet-184	248	25	neurology	neurology	NOUN
admet-184	248	26	294	294	NUM
admet-184	248	27	(	(	PUNCT
admet-184	248	28	1990	1990	NUM
admet-184	248	29	)	)	PUNCT
admet-184	248	30	293	293	NUM
admet-184	248	31	-	-	SYM
admet-184	248	32	305	305	NUM
admet-184	248	33	.	.	PUNCT
admet-184	249	1	[	[	X
admet-184	249	2	23	23	NUM
admet-184	249	3	]	]	X
admet-184	249	4	f.	f.	PROPN
admet-184	249	5	bojsen	bojsen	PROPN
admet-184	249	6	-	-	PUNCT
admet-184	249	7	moller	moller	PROPN
admet-184	249	8	,	,	PUNCT
admet-184	249	9	the	the	DET
admet-184	249	10	journal	journal	NOUN
admet-184	249	11	of	of	ADP
admet-184	249	12	comparative	comparative	ADJ
admet-184	249	13	neurology	neurology	NOUN
admet-184	249	14	159	159	NUM
admet-184	249	15	(	(	PUNCT
admet-184	249	16	1975	1975	NUM
admet-184	249	17	)	)	PUNCT
admet-184	249	18	245	245	NUM
admet-184	249	19	-	-	SYM
admet-184	249	20	256	256	NUM
admet-184	249	21	.	.	PUNCT
admet-184	250	1	[	[	X
admet-184	250	2	24	24	NUM
admet-184	250	3	]	]	X
admet-184	250	4	h.r	h.r	PROPN
admet-184	250	5	.	.	PROPN
admet-184	250	6	costantino	costantino	PROPN
admet-184	250	7	,	,	PUNCT
admet-184	250	8	l.	l.	PROPN
admet-184	250	9	illum	illum	PROPN
admet-184	250	10	,	,	PUNCT
admet-184	250	11	g.	g.	PROPN
admet-184	250	12	brandt	brandt	PROPN
admet-184	250	13	,	,	PUNCT
admet-184	250	14	p.h	p.h	PROPN
admet-184	250	15	.	.	PROPN
admet-184	250	16	johnson	johnson	PROPN
admet-184	250	17	,	,	PUNCT
admet-184	250	18	s.c	s.c	PROPN
admet-184	250	19	.	.	PROPN
admet-184	250	20	quay	quay	PROPN
admet-184	250	21	,	,	PUNCT
admet-184	250	22	international	international	ADJ
admet-184	250	23	journal	journal	NOUN
admet-184	250	24	of	of	ADP
admet-184	250	25	pharmaceutics	pharmaceutic	NOUN
admet-184	250	26	337	337	NUM
admet-184	250	27	(	(	PUNCT
admet-184	250	28	2007	2007	NUM
admet-184	250	29	)	)	PUNCT
admet-184	250	30	1	1	NUM
admet-184	250	31	-	-	SYM
admet-184	250	32	24	24	NUM
admet-184	250	33	.	.	PUNCT
admet-184	251	1	[	[	X
admet-184	251	2	25	25	NUM
admet-184	251	3	]	]	PUNCT
admet-184	251	4	p.	p.	NOUN
admet-184	251	5	field	field	NOUN
admet-184	251	6	,	,	PUNCT
admet-184	251	7	y.	y.	PROPN
admet-184	251	8	li	li	PROPN
admet-184	251	9	,	,	PUNCT
admet-184	251	10	g.	g.	PROPN
admet-184	251	11	raisman	raisman	PROPN
admet-184	251	12	,	,	PUNCT
admet-184	251	13	journal	journal	NOUN
admet-184	251	14	of	of	ADP
admet-184	251	15	neurocytology	neurocytology	NOUN
admet-184	251	16	32	32	NUM
admet-184	251	17	(	(	PUNCT
admet-184	251	18	2003	2003	NUM
admet-184	251	19	)	)	PUNCT
admet-184	251	20	317	317	NUM
admet-184	251	21	-	-	SYM
admet-184	251	22	324	324	NUM
admet-184	251	23	.	.	PUNCT
admet-184	252	1	[	[	X
admet-184	252	2	26	26	NUM
admet-184	252	3	]	]	X
admet-184	252	4	s.t	s.t	PROPN
admet-184	252	5	.	.	PROPN
admet-184	252	6	carmichael	carmichael	PROPN
admet-184	252	7	,	,	PUNCT
admet-184	252	8	m.c	m.c	PROPN
admet-184	252	9	.	.	PROPN
admet-184	252	10	clugnet	clugnet	PROPN
admet-184	252	11	,	,	PUNCT
admet-184	252	12	j.l	j.l	PROPN
admet-184	252	13	.	.	PROPN
admet-184	252	14	price	price	NOUN
admet-184	252	15	,	,	PUNCT
admet-184	252	16	the	the	DET
admet-184	252	17	journal	journal	NOUN
admet-184	252	18	of	of	ADP
admet-184	252	19	comparative	comparative	ADJ
admet-184	252	20	neurology	neurology	NOUN
admet-184	252	21	346	346	NUM
admet-184	252	22	(	(	PUNCT
admet-184	252	23	1994	1994	NUM
admet-184	252	24	)	)	PUNCT
admet-184	252	25	403	403	NUM
admet-184	252	26	-	-	SYM
admet-184	252	27	434	434	NUM
admet-184	252	28	.	.	PUNCT
admet-184	253	1	[	[	X
admet-184	253	2	27	27	NUM
admet-184	253	3	]	]	X
admet-184	253	4	r.g	r.g	PROPN
admet-184	253	5	.	.	PROPN
admet-184	253	6	thorne	thorne	PROPN
admet-184	253	7	,	,	PUNCT
admet-184	253	8	c.r	c.r	PROPN
admet-184	253	9	.	.	PROPN
admet-184	253	10	emory	emory	PROPN
admet-184	253	11	,	,	PUNCT
admet-184	253	12	t.a	t.a	PROPN
admet-184	253	13	.	.	PROPN
admet-184	253	14	ala	ala	PROPN
admet-184	253	15	,	,	PUNCT
admet-184	253	16	w.h	w.h	PROPN
admet-184	253	17	.	.	PROPN
admet-184	253	18	frey	frey	PROPN
admet-184	253	19	,	,	PUNCT
admet-184	253	20	brain	brain	NOUN
admet-184	253	21	research	research	NOUN
admet-184	253	22	692	692	NUM
admet-184	253	23	(	(	PUNCT
admet-184	253	24	1995	1995	NUM
admet-184	253	25	)	)	PUNCT
admet-184	253	26	278	278	NUM
admet-184	253	27	-	-	SYM
admet-184	253	28	282	282	NUM
admet-184	253	29	.	.	PUNCT
admet-184	254	1	[	[	X
admet-184	254	2	28	28	NUM
admet-184	254	3	]	]	X
admet-184	254	4	r.l	r.l	PROPN
admet-184	254	5	.	.	PROPN
admet-184	254	6	doty	doty	PROPN
admet-184	254	7	,	,	PUNCT
admet-184	254	8	annals	annal	NOUN
admet-184	254	9	of	of	ADP
admet-184	254	10	neurology	neurology	NOUN
admet-184	254	11	63	63	NUM
admet-184	254	12	(	(	PUNCT
admet-184	254	13	2008	2008	NUM
admet-184	254	14	)	)	PUNCT
admet-184	254	15	7	7	NUM
admet-184	254	16	-	-	SYM
admet-184	254	17	15	15	NUM
admet-184	254	18	.	.	PUNCT
admet-184	255	1	[	[	X
admet-184	255	2	29	29	NUM
admet-184	255	3	]	]	PUNCT
admet-184	255	4	k.	k.	PROPN
admet-184	255	5	kristensson	kristensson	PROPN
admet-184	255	6	,	,	PUNCT
admet-184	255	7	y.	y.	PROPN
admet-184	255	8	olsson	olsson	PROPN
admet-184	255	9	,	,	PUNCT
admet-184	255	10	acta	acta	PROPN
admet-184	255	11	neuropathologica	neuropathologica	PROPN
admet-184	255	12	19	19	NUM
admet-184	255	13	(	(	PUNCT
admet-184	255	14	1971	1971	NUM
admet-184	255	15	)	)	PUNCT
admet-184	255	16	145	145	NUM
admet-184	255	17	-	-	SYM
admet-184	255	18	154	154	NUM
admet-184	255	19	.	.	PUNCT
admet-184	256	1	[	[	X
admet-184	256	2	30	30	NUM
admet-184	256	3	]	]	X
admet-184	256	4	r.d	r.d	PROPN
admet-184	256	5	.	.	PROPN
admet-184	256	6	broadwell	broadwell	PROPN
admet-184	256	7	,	,	PUNCT
admet-184	256	8	b.j	b.j	PROPN
admet-184	256	9	.	.	PROPN
admet-184	256	10	balin	balin	PROPN
admet-184	256	11	,	,	PUNCT
admet-184	256	12	the	the	DET
admet-184	256	13	journal	journal	NOUN
admet-184	256	14	of	of	ADP
admet-184	256	15	comparative	comparative	ADJ
admet-184	256	16	neurology	neurology	NOUN
admet-184	256	17	242	242	NUM
admet-184	256	18	(	(	PUNCT
admet-184	256	19	1985	1985	NUM
admet-184	256	20	)	)	PUNCT
admet-184	256	21	632	632	NUM
admet-184	256	22	-	-	SYM
admet-184	256	23	650	650	NUM
admet-184	256	24	.	.	PUNCT
admet-184	257	1	[	[	X
admet-184	257	2	31	31	NUM
admet-184	257	3	]	]	PUNCT
admet-184	257	4	h.	h.	PROPN
admet-184	257	5	baker	baker	PROPN
admet-184	257	6	,	,	PUNCT
admet-184	257	7	r.f	r.f	PROPN
admet-184	257	8	.	.	PROPN
admet-184	257	9	spencer	spencer	PROPN
admet-184	257	10	,	,	PUNCT
admet-184	257	11	experimental	experimental	ADJ
admet-184	257	12	brain	brain	NOUN
admet-184	257	13	research	research	NOUN
admet-184	257	14	63	63	NUM
admet-184	257	15	(	(	PUNCT
admet-184	257	16	1986	1986	NUM
admet-184	257	17	)	)	PUNCT
admet-184	257	18	461	461	NUM
admet-184	257	19	-	-	SYM
admet-184	257	20	473	473	NUM
admet-184	257	21	.	.	PUNCT
admet-184	258	1	[	[	X
admet-184	258	2	32	32	NUM
admet-184	258	3	]	]	PUNCT
admet-184	258	4	k.	k.	PROPN
admet-184	258	5	kristensson	kristensson	PROPN
admet-184	258	6	,	,	PUNCT
admet-184	258	7	nature	nature	NOUN
admet-184	258	8	reviews	review	NOUN
admet-184	258	9	.	.	PUNCT
admet-184	259	1	neuroscience	neuroscience	NOUN
admet-184	259	2	12	12	NUM
admet-184	259	3	(	(	PUNCT
admet-184	259	4	2011	2011	NUM
admet-184	259	5	)	)	PUNCT
admet-184	259	6	345	345	NUM
admet-184	259	7	-	-	SYM
admet-184	259	8	357	357	NUM
admet-184	259	9	.	.	PUNCT
admet-184	260	1	[	[	X
admet-184	260	2	33	33	NUM
admet-184	260	3	]	]	PUNCT
admet-184	260	4	f.	f.	PROPN
admet-184	260	5	anton	anton	PROPN
admet-184	260	6	,	,	PUNCT
admet-184	260	7	p.	p.	NOUN
admet-184	260	8	peppel	peppel	NOUN
admet-184	260	9	,	,	PUNCT
admet-184	260	10	neuroscience	neuroscience	NOUN
admet-184	260	11	41	41	NUM
admet-184	260	12	(	(	PUNCT
admet-184	260	13	1991	1991	NUM
admet-184	260	14	)	)	PUNCT
admet-184	260	15	617	617	NUM
admet-184	260	16	-	-	SYM
admet-184	260	17	628	628	NUM
admet-184	260	18	.	.	PUNCT
admet-184	261	1	[	[	X
admet-184	261	2	34	34	NUM
admet-184	261	3	]	]	PUNCT
admet-184	261	4	a.m.	a.m.	ADV
admet-184	261	5	deatly	deatly	ADV
admet-184	261	6	,	,	PUNCT
admet-184	261	7	a.t	a.t	PROPN
admet-184	261	8	.	.	PROPN
admet-184	261	9	haase	haase	PROPN
admet-184	261	10	,	,	PUNCT
admet-184	261	11	p.h	p.h	PROPN
admet-184	261	12	.	.	PROPN
admet-184	261	13	fewster	fewster	PROPN
admet-184	261	14	,	,	PUNCT
admet-184	261	15	e.	e.	PROPN
admet-184	261	16	lewis	lewis	PROPN
admet-184	261	17	,	,	PUNCT
admet-184	261	18	m.j	m.j	PROPN
admet-184	261	19	.	.	PROPN
admet-184	261	20	ball	ball	PROPN
admet-184	261	21	,	,	PUNCT
admet-184	261	22	neuropathology	neuropathology	NOUN
admet-184	261	23	and	and	CCONJ
admet-184	261	24	applied	apply	VERB
admet-184	261	25	neurobiology	neurobiology	NOUN
admet-184	261	26	16	16	NUM
admet-184	261	27	(	(	PUNCT
admet-184	261	28	1990	1990	NUM
admet-184	261	29	)	)	PUNCT
admet-184	261	30	213	213	NUM
admet-184	261	31	-	-	SYM
admet-184	261	32	223	223	NUM
admet-184	261	33	.	.	PUNCT
admet-184	262	1	[	[	X
admet-184	262	2	35	35	NUM
admet-184	262	3	]	]	PUNCT
admet-184	262	4	k.	k.	PROPN
admet-184	262	5	hosoya	hosoya	PROPN
admet-184	262	6	,	,	PUNCT
admet-184	262	7	h.	h.	PROPN
admet-184	262	8	kubo	kubo	PROPN
admet-184	262	9	,	,	PUNCT
admet-184	262	10	h.	h.	PROPN
admet-184	262	11	natsume	natsume	PROPN
admet-184	262	12	,	,	PUNCT
admet-184	262	13	k.	k.	PROPN
admet-184	262	14	sugibayashi	sugibayashi	PROPN
admet-184	262	15	,	,	PUNCT
admet-184	262	16	y.	y.	PROPN
admet-184	262	17	morimoto	morimoto	PROPN
admet-184	262	18	,	,	PUNCT
admet-184	262	19	s.	s.	PROPN
admet-184	262	20	yamashita	yamashita	PROPN
admet-184	262	21	,	,	PUNCT
admet-184	262	22	biopharmaceutics	biopharmaceutics	PROPN
admet-184	262	23	&	&	CCONJ
admet-184	262	24	drug	drug	PROPN
admet-184	262	25	disposition	disposition	NOUN
admet-184	262	26	14	14	NUM
admet-184	262	27	(	(	PUNCT
admet-184	262	28	1993	1993	NUM
admet-184	262	29	)	)	PUNCT
admet-184	262	30	685	685	NUM
admet-184	262	31	-	-	SYM
admet-184	262	32	695	695	NUM
admet-184	262	33	.	.	PUNCT
admet-184	263	1	[	[	X
admet-184	263	2	36	36	NUM
admet-184	263	3	]	]	X
admet-184	263	4	s.s	s.s	PROPN
admet-184	263	5	.	.	PROPN
admet-184	263	6	davis	davis	PROPN
admet-184	263	7	,	,	PUNCT
admet-184	263	8	l.	l.	PROPN
admet-184	263	9	illum	illum	PROPN
admet-184	263	10	,	,	PUNCT
admet-184	263	11	clinical	clinical	ADJ
admet-184	263	12	pharmacokinetics	pharmacokinetic	NOUN
admet-184	263	13	42	42	NUM
admet-184	263	14	(	(	PUNCT
admet-184	263	15	2003	2003	NUM
admet-184	263	16	)	)	PUNCT
admet-184	263	17	1107	1107	NUM
admet-184	263	18	-	-	SYM
admet-184	263	19	1128	1128	NUM
admet-184	263	20	.	.	PUNCT
admet-184	264	1	[	[	X
admet-184	264	2	37	37	NUM
admet-184	264	3	]	]	X
admet-184	264	4	r.g	r.g	PROPN
admet-184	264	5	.	.	PROPN
admet-184	264	6	thorne	thorne	PROPN
admet-184	264	7	,	,	PUNCT
admet-184	264	8	g.j	g.j	PROPN
admet-184	264	9	.	.	PROPN
admet-184	264	10	pronk	pronk	PROPN
admet-184	264	11	,	,	PUNCT
admet-184	264	12	v.	v.	CCONJ
admet-184	264	13	padmanabhan	padmanabhan	PROPN
admet-184	264	14	,	,	PUNCT
admet-184	264	15	w.h	w.h	PROPN
admet-184	264	16	.	.	PROPN
admet-184	264	17	frey	frey	PROPN
admet-184	264	18	,	,	PUNCT
admet-184	264	19	neuroscience	neuroscience	NOUN
admet-184	264	20	127	127	NUM
admet-184	264	21	(	(	PUNCT
admet-184	264	22	2004	2004	NUM
admet-184	264	23	)	)	PUNCT
admet-184	264	24	481	481	NUM
admet-184	264	25	-	-	SYM
admet-184	264	26	496	496	NUM
admet-184	264	27	.	.	PUNCT
admet-184	265	1	[	[	X
admet-184	265	2	38	38	NUM
admet-184	265	3	]	]	X
admet-184	265	4	r.g	r.g	PROPN
admet-184	265	5	.	.	PROPN
admet-184	265	6	thorne	thorne	PROPN
admet-184	265	7	,	,	PUNCT
admet-184	265	8	l.r	l.r	PROPN
admet-184	265	9	.	.	PROPN
admet-184	265	10	hanson	hanson	PROPN
admet-184	265	11	,	,	PUNCT
admet-184	265	12	t.m	t.m	PROPN
admet-184	265	13	.	.	PROPN
admet-184	265	14	ross	ross	PROPN
admet-184	265	15	,	,	PUNCT
admet-184	265	16	d.	d.	PROPN
admet-184	265	17	tung	tung	PROPN
admet-184	265	18	,	,	PUNCT
admet-184	265	19	w.h	w.h	PROPN
admet-184	265	20	.	.	PROPN
admet-184	265	21	frey	frey	PROPN
admet-184	265	22	,	,	PUNCT
admet-184	265	23	neuroscience	neuroscience	NOUN
admet-184	265	24	152	152	NUM
admet-184	265	25	(	(	PUNCT
admet-184	265	26	2008	2008	NUM
admet-184	265	27	)	)	PUNCT
admet-184	265	28	785	785	NUM
admet-184	265	29	-	-	SYM
admet-184	265	30	797	797	NUM
admet-184	265	31	.	.	PUNCT
admet-184	266	1	[	[	X
admet-184	266	2	39	39	NUM
admet-184	266	3	]	]	PUNCT
admet-184	266	4	m.	m.	NOUN
admet-184	266	5	johnston	johnston	PROPN
admet-184	266	6	,	,	PUNCT
admet-184	266	7	a.	a.	NOUN
admet-184	266	8	zakharov	zakharov	PROPN
admet-184	266	9	,	,	PUNCT
admet-184	266	10	c.	c.	PROPN
admet-184	266	11	papaiconomou	papaiconomou	PROPN
admet-184	266	12	,	,	PUNCT
admet-184	266	13	g.	g.	PROPN
admet-184	266	14	salmasi	salmasi	PROPN
admet-184	266	15	,	,	PUNCT
admet-184	266	16	d.	d.	PROPN
admet-184	266	17	armstrong	armstrong	PROPN
admet-184	266	18	,	,	PUNCT
admet-184	266	19	cerebrospinal	cerebrospinal	ADJ
admet-184	266	20	fluid	fluid	NOUN
admet-184	266	21	research	research	NOUN
admet-184	266	22	1	1	NUM
admet-184	266	23	(	(	PUNCT
admet-184	266	24	2004	2004	NUM
admet-184	266	25	)	)	PUNCT
admet-184	266	26	2	2	NUM
admet-184	266	27	.	.	PUNCT
admet-184	267	1	[	[	X
admet-184	267	2	40	40	NUM
admet-184	267	3	]	]	X
admet-184	267	4	c.	c.	PROPN
admet-184	267	5	benedict	benedict	PROPN
admet-184	267	6	,	,	PUNCT
admet-184	267	7	m.	m.	PROPN
admet-184	267	8	hallschmid	hallschmid	PROPN
admet-184	267	9	,	,	PUNCT
admet-184	267	10	a.	a.	NOUN
admet-184	267	11	hatke	hatke	PROPN
admet-184	267	12	,	,	PUNCT
admet-184	267	13	b.	b.	PROPN
admet-184	267	14	schultes	schultes	PROPN
admet-184	267	15	,	,	PUNCT
admet-184	267	16	h.l	h.l	PROPN
admet-184	267	17	.	.	PROPN
admet-184	267	18	fehm	fehm	PROPN
admet-184	267	19	,	,	PUNCT
admet-184	267	20	j.	j.	PROPN
admet-184	267	21	born	bear	VERB
admet-184	267	22	,	,	PUNCT
admet-184	267	23	w.	w.	PROPN
admet-184	267	24	kern	kern	PROPN
admet-184	267	25	,	,	PUNCT
admet-184	267	26	psychoneuroendocrinology	psychoneuroendocrinology	NOUN
admet-184	267	27	29	29	NUM
admet-184	267	28	(	(	PUNCT
admet-184	267	29	2004	2004	NUM
admet-184	267	30	)	)	PUNCT
admet-184	267	31	1326	1326	NUM
admet-184	267	32	-	-	SYM
admet-184	267	33	1334	1334	NUM
admet-184	267	34	.	.	PUNCT
admet-184	268	1	[	[	X
admet-184	268	2	41	41	NUM
admet-184	268	3	]	]	X
admet-184	268	4	e.	e.	PROPN
admet-184	268	5	shemesh	shemesh	PROPN
admet-184	268	6	,	,	PUNCT
admet-184	268	7	a.	a.	NOUN
admet-184	268	8	rudich	rudich	PROPN
admet-184	268	9	,	,	PUNCT
admet-184	268	10	i.	i.	PROPN
admet-184	268	11	harman	harman	PROPN
admet-184	268	12	-	-	PUNCT
admet-184	268	13	boehm	boehm	NOUN
admet-184	268	14	,	,	PUNCT
admet-184	268	15	t.	t.	NOUN
admet-184	268	16	cukierman	cukierman	NOUN
admet-184	268	17	-	-	PUNCT
admet-184	268	18	yaffe	yaffe	NOUN
admet-184	268	19	,	,	PUNCT
admet-184	268	20	the	the	DET
admet-184	268	21	journal	journal	NOUN
admet-184	268	22	of	of	ADP
admet-184	268	23	clinical	clinical	ADJ
admet-184	268	24	endocrinology	endocrinology	NOUN
admet-184	268	25	and	and	CCONJ
admet-184	268	26	metabolism	metabolism	NOUN
admet-184	268	27	97	97	NUM
admet-184	268	28	(	(	PUNCT
admet-184	268	29	2012	2012	NUM
admet-184	268	30	)	)	PUNCT
admet-184	268	31	366	366	NUM
admet-184	268	32	-	-	SYM
admet-184	268	33	376	376	NUM
admet-184	268	34	.	.	PUNCT
admet-184	269	1	[	[	X
admet-184	269	2	42	42	NUM
admet-184	269	3	]	]	X
admet-184	269	4	l.	l.	PROPN
admet-184	269	5	plum	plum	PROPN
admet-184	269	6	,	,	PUNCT
admet-184	269	7	m.	m.	PROPN
admet-184	269	8	schubert	schubert	PROPN
admet-184	269	9	,	,	PUNCT
admet-184	269	10	j.c	j.c	PROPN
admet-184	269	11	.	.	PROPN
admet-184	269	12	bruning	bruning	PROPN
admet-184	269	13	,	,	PUNCT
admet-184	269	14	trends	trend	NOUN
admet-184	269	15	in	in	ADP
admet-184	269	16	endocrinology	endocrinology	NOUN
admet-184	269	17	and	and	CCONJ
admet-184	269	18	metabolism	metabolism	NOUN
admet-184	269	19	:	:	PUNCT
admet-184	269	20	tem	tem	PROPN
admet-184	269	21	16	16	NUM
admet-184	269	22	(	(	PUNCT
admet-184	269	23	2005	2005	NUM
admet-184	269	24	)	)	PUNCT
admet-184	269	25	59	59	NUM
admet-184	269	26	-	-	SYM
admet-184	269	27	65	65	NUM
admet-184	269	28	.	.	PUNCT
admet-184	270	1	[	[	X
admet-184	270	2	43	43	NUM
admet-184	270	3	]	]	X
admet-184	270	4	g.j	g.j	PROPN
admet-184	270	5	.	.	PROPN
admet-184	270	6	francis	francis	PROPN
admet-184	270	7	,	,	PUNCT
admet-184	270	8	j.a	j.a	PROPN
admet-184	270	9	.	.	PROPN
admet-184	270	10	martinez	martinez	PROPN
admet-184	270	11	,	,	PUNCT
admet-184	270	12	w.q	w.q	PROPN
admet-184	270	13	.	.	PROPN
admet-184	270	14	liu	liu	PROPN
admet-184	270	15	,	,	PUNCT
admet-184	270	16	k.	k.	PROPN
admet-184	270	17	xu	xu	PROPN
admet-184	270	18	,	,	PUNCT
admet-184	270	19	a.	a.	PROPN
admet-184	270	20	ayer	ayer	PROPN
admet-184	270	21	,	,	PUNCT
admet-184	270	22	j.	j.	PROPN
admet-184	270	23	fine	fine	PROPN
admet-184	270	24	,	,	PUNCT
admet-184	270	25	u.i	u.i	PROPN
admet-184	270	26	.	.	PROPN
admet-184	270	27	tuor	tuor	PROPN
admet-184	270	28	,	,	PUNCT
admet-184	270	29	g.	g.	PROPN
admet-184	270	30	glazner	glazner	PROPN
admet-184	270	31	,	,	PUNCT
admet-184	270	32	l.r	l.r	PROPN
admet-184	270	33	.	.	PROPN
admet-184	270	34	hanson	hanson	PROPN
admet-184	270	35	,	,	PUNCT
admet-184	270	36	w.h	w.h	PROPN
admet-184	270	37	.	.	PROPN
admet-184	270	38	frey	frey	PROPN
admet-184	270	39	,	,	PUNCT
admet-184	270	40	c.	c.	PROPN
admet-184	270	41	toth	toth	PROPN
admet-184	270	42	,	,	PUNCT
admet-184	270	43	brain	brain	PROPN
admet-184	270	44	:	:	PUNCT
admet-184	270	45	a	a	DET
admet-184	270	46	journal	journal	NOUN
admet-184	270	47	of	of	ADP
admet-184	270	48	neurology	neurology	NOUN
admet-184	270	49	131	131	NUM
admet-184	270	50	(	(	PUNCT
admet-184	270	51	2008	2008	NUM
admet-184	270	52	)	)	PUNCT
admet-184	270	53	3311	3311	NUM
admet-184	270	54	-	-	SYM
admet-184	270	55	3334	3334	NUM
admet-184	270	56	.	.	PUNCT
admet-184	271	1	[	[	X
admet-184	271	2	44	44	NUM
admet-184	271	3	]	]	PUNCT
admet-184	271	4	s.	s.	PROPN
admet-184	271	5	craft	craft	PROPN
admet-184	271	6	,	,	PUNCT
admet-184	271	7	g.s	g.s	PROPN
admet-184	271	8	.	.	PROPN
admet-184	271	9	watson	watson	PROPN
admet-184	271	10	,	,	PUNCT
admet-184	271	11	the	the	DET
admet-184	271	12	lancet	lancet	NOUN
admet-184	271	13	neurology	neurology	NOUN
admet-184	271	14	3	3	NUM
admet-184	271	15	(	(	PUNCT
admet-184	271	16	2004	2004	NUM
admet-184	271	17	)	)	PUNCT
admet-184	271	18	169	169	NUM
admet-184	271	19	-	-	SYM
admet-184	271	20	178	178	NUM
admet-184	271	21	.	.	PUNCT
admet-184	272	1	[	[	X
admet-184	272	2	45	45	NUM
admet-184	272	3	]	]	PUNCT
admet-184	272	4	j.	j.	PROPN
admet-184	272	5	freiherr	freiherr	PROPN
admet-184	272	6	,	,	PUNCT
admet-184	272	7	m.	m.	NOUN
admet-184	272	8	hallschmid	hallschmid	PROPN
admet-184	272	9	,	,	PUNCT
admet-184	272	10	w.h	w.h	PROPN
admet-184	272	11	.	.	PROPN
admet-184	272	12	frey	frey	PROPN
admet-184	272	13	,	,	PUNCT
admet-184	272	14	2nd	2nd	PROPN
admet-184	272	15	,	,	PUNCT
admet-184	272	16	y.f	y.f	PROPN
admet-184	272	17	.	.	PUNCT
admet-184	272	18	brunner	brunner	PROPN
admet-184	272	19	,	,	PUNCT
admet-184	272	20	c.d	c.d	PROPN
admet-184	272	21	.	.	PROPN
admet-184	272	22	chapman	chapman	PROPN
admet-184	272	23	,	,	PUNCT
admet-184	272	24	c.	c.	PROPN
admet-184	272	25	holscher	holscher	PROPN
admet-184	272	26	,	,	PUNCT
admet-184	272	27	s.	s.	PROPN
admet-184	272	28	craft	craft	PROPN
admet-184	272	29	,	,	PUNCT
admet-184	272	30	f.g	f.g	NOUN
admet-184	272	31	.	.	PROPN
admet-184	272	32	de	de	X
admet-184	272	33	felice	felice	PROPN
admet-184	272	34	,	,	PUNCT
admet-184	272	35	c.	c.	PROPN
admet-184	272	36	benedict	benedict	PROPN
admet-184	272	37	,	,	PUNCT
admet-184	272	38	cns	cns	PROPN
admet-184	272	39	drugs	drug	NOUN
admet-184	272	40	27	27	NUM
admet-184	272	41	(	(	PUNCT
admet-184	272	42	2013	2013	NUM
admet-184	272	43	)	)	PUNCT
admet-184	272	44	505	505	NUM
admet-184	272	45	-	-	SYM
admet-184	272	46	514	514	NUM
admet-184	272	47	.	.	PUNCT
admet-184	273	1	[	[	X
admet-184	273	2	46	46	NUM
admet-184	273	3	]	]	X
admet-184	273	4	s.	s.	PROPN
admet-184	273	5	craft	craft	PROPN
admet-184	273	6	,	,	PUNCT
admet-184	273	7	archives	archive	NOUN
admet-184	273	8	of	of	ADP
admet-184	273	9	neurology	neurology	NOUN
admet-184	273	10	66	66	NUM
admet-184	273	11	(	(	PUNCT
admet-184	273	12	2009	2009	NUM
admet-184	273	13	)	)	PUNCT
admet-184	273	14	300	300	NUM
admet-184	273	15	-	-	SYM
admet-184	273	16	305	305	NUM
admet-184	273	17	.	.	PUNCT
admet-184	274	1	[	[	X
admet-184	274	2	47	47	NUM
admet-184	274	3	]	]	PUNCT
admet-184	274	4	m.	m.	PROPN
admet-184	274	5	hong	hong	PROPN
admet-184	274	6	,	,	PUNCT
admet-184	274	7	v.m	v.m	PROPN
admet-184	274	8	.	.	PROPN
admet-184	274	9	lee	lee	PROPN
admet-184	274	10	,	,	PUNCT
admet-184	274	11	the	the	DET
admet-184	274	12	journal	journal	NOUN
admet-184	274	13	of	of	ADP
admet-184	274	14	biological	biological	ADJ
admet-184	274	15	chemistry	chemistry	NOUN
admet-184	274	16	272	272	NUM
admet-184	274	17	(	(	PUNCT
admet-184	274	18	1997	1997	NUM
admet-184	274	19	)	)	PUNCT
admet-184	274	20	19547	19547	NUM
admet-184	274	21	-	-	SYM
admet-184	274	22	19553	19553	NUM
admet-184	274	23	.	.	PUNCT
admet-184	275	1	[	[	X
admet-184	275	2	48	48	NUM
admet-184	275	3	]	]	X
admet-184	275	4	d.r	d.r	PROPN
admet-184	275	5	.	.	PROPN
admet-184	275	6	marks	marks	PROPN
admet-184	275	7	,	,	PUNCT
admet-184	275	8	k.	k.	PROPN
admet-184	275	9	tucker	tucker	PROPN
admet-184	275	10	,	,	PUNCT
admet-184	275	11	m.a	m.a	PROPN
admet-184	275	12	.	.	PROPN
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admet-184	275	14	,	,	PUNCT
admet-184	275	15	t.g	t.g	PROPN
admet-184	275	16	.	.	PROPN
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admet-184	275	18	,	,	PUNCT
admet-184	275	19	d.a	d.a	PROPN
admet-184	275	20	.	.	PROPN
admet-184	275	21	fadool	fadool	PROPN
admet-184	275	22	,	,	PUNCT
admet-184	275	23	the	the	DET
admet-184	275	24	journal	journal	NOUN
admet-184	275	25	of	of	ADP
admet-184	275	26	neuroscience	neuroscience	NOUN
admet-184	275	27	:	:	PUNCT
admet-184	275	28	the	the	DET
admet-184	275	29	official	official	ADJ
admet-184	275	30	journal	journal	NOUN
admet-184	275	31	of	of	ADP
admet-184	275	32	the	the	DET
admet-184	275	33	society	society	NOUN
admet-184	275	34	for	for	ADP
admet-184	275	35	neuroscience	neuroscience	NOUN
admet-184	275	36	29	29	NUM
admet-184	275	37	(	(	PUNCT
admet-184	275	38	2009	2009	NUM
admet-184	275	39	)	)	PUNCT
admet-184	275	40	6734	6734	NUM
admet-184	275	41	-	-	SYM
admet-184	275	42	6751	6751	NUM
admet-184	275	43	.	.	PUNCT
admet-184	276	1	admet	admet	PROPN
admet-184	276	2	&	&	CCONJ
admet-184	276	3	dmpk	dmpk	PROPN
admet-184	276	4	3(3	3(3	NUM
admet-184	276	5	)	)	PUNCT
admet-184	276	6	(	(	PUNCT
admet-184	276	7	2015	2015	NUM
admet-184	276	8	)	)	PUNCT
admet-184	276	9	190	190	NUM
admet-184	276	10	-	-	SYM
admet-184	276	11	202	202	NUM
admet-184	276	12	intranasal	intranasal	ADJ
admet-184	276	13	insulin	insulin	NOUN
admet-184	276	14	as	as	ADP
admet-184	276	15	hope	hope	NOUN
admet-184	276	16	for	for	ADP
admet-184	276	17	ad	ad	NOUN
admet-184	276	18	?	?	PUNCT
admet-184	277	1	doi	doi	NOUN
admet-184	277	2	:	:	PUNCT
admet-184	277	3	10.5599	10.5599	NUM
admet-184	277	4	/	/	SYM
admet-184	277	5	admet.3.3.184	admet.3.3.184	NUM
admet-184	277	6	201	201	NUM
admet-184	277	7	[	[	X
admet-184	277	8	49	49	NUM
admet-184	277	9	]	]	X
admet-184	277	10	m.j	m.j	PROPN
admet-184	277	11	.	.	PROPN
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admet-184	277	13	,	,	PUNCT
admet-184	277	14	l.	l.	PROPN
admet-184	277	15	cao	cao	PROPN
admet-184	277	16	,	,	PUNCT
admet-184	277	17	d.s	d.s	PROPN
admet-184	277	18	.	.	PROPN
admet-184	277	19	zuzga	zuzga	PROPN
admet-184	277	20	,	,	PUNCT
admet-184	277	21	j.s	j.s	PROPN
admet-184	277	22	.	.	PROPN
admet-184	277	23	francis	francis	PROPN
admet-184	277	24	,	,	PUNCT
admet-184	277	25	h.l	h.l	PROPN
admet-184	277	26	.	.	PROPN
admet-184	277	27	fitzsimons	fitzsimons	PROPN
admet-184	277	28	,	,	PUNCT
admet-184	277	29	x.	x.	PROPN
admet-184	277	30	jiao	jiao	PROPN
admet-184	277	31	,	,	PUNCT
admet-184	277	32	r.j	r.j	PROPN
admet-184	277	33	.	.	PROPN
admet-184	277	34	bland	bland	PROPN
admet-184	277	35	,	,	PUNCT
admet-184	277	36	m.	m.	NOUN
admet-184	277	37	klugmann	klugmann	PROPN
admet-184	277	38	,	,	PUNCT
admet-184	277	39	w.a	w.a	PROPN
admet-184	277	40	.	.	PROPN
admet-184	277	41	banks	banks	PROPN
admet-184	277	42	,	,	PUNCT
admet-184	277	43	d.j	d.j	PROPN
admet-184	277	44	.	.	PROPN
admet-184	277	45	drucker	drucker	PROPN
admet-184	277	46	,	,	PUNCT
admet-184	277	47	c.n	c.n	PROPN
admet-184	277	48	.	.	PROPN
admet-184	277	49	haile	haile	PROPN
admet-184	277	50	,	,	PUNCT
admet-184	277	51	nature	nature	NOUN
admet-184	277	52	medicine	medicine	NOUN
admet-184	277	53	9	9	NUM
admet-184	277	54	(	(	PUNCT
admet-184	277	55	2003	2003	NUM
admet-184	277	56	)	)	PUNCT
admet-184	277	57	1173	1173	NUM
admet-184	277	58	-	-	SYM
admet-184	277	59	1179	1179	NUM
admet-184	277	60	.	.	PUNCT
admet-184	278	1	[	[	X
admet-184	278	2	50	50	NUM
admet-184	278	3	]	]	X
admet-184	278	4	w.a	w.a	PROPN
admet-184	278	5	.	.	PROPN
admet-184	278	6	banks	banks	PROPN
admet-184	278	7	,	,	PUNCT
admet-184	278	8	m.j	m.j	PROPN
admet-184	278	9	.	.	PROPN
admet-184	278	10	during	during	ADP
admet-184	278	11	,	,	PUNCT
admet-184	278	12	m.l	m.l	PROPN
admet-184	278	13	.	.	PROPN
admet-184	278	14	niehoff	niehoff	PROPN
admet-184	278	15	,	,	PUNCT
admet-184	278	16	the	the	DET
admet-184	278	17	journal	journal	NOUN
admet-184	278	18	of	of	ADP
admet-184	278	19	pharmacology	pharmacology	NOUN
admet-184	278	20	and	and	CCONJ
admet-184	278	21	experimental	experimental	ADJ
admet-184	278	22	therapeutics	therapeutic	NOUN
admet-184	278	23	309	309	NUM
admet-184	278	24	(	(	PUNCT
admet-184	278	25	2004	2004	NUM
admet-184	278	26	)	)	PUNCT
admet-184	278	27	469	469	NUM
admet-184	278	28	-	-	SYM
admet-184	278	29	475	475	NUM
admet-184	278	30	.	.	PUNCT
admet-184	279	1	[	[	X
admet-184	279	2	51	51	NUM
admet-184	279	3	]	]	X
admet-184	279	4	m.a	m.a	PROPN
admet-184	279	5	.	.	PROPN
admet-184	279	6	reger	reger	PROPN
admet-184	279	7	,	,	PUNCT
admet-184	279	8	g.s	g.s	PROPN
admet-184	279	9	.	.	PROPN
admet-184	279	10	watson	watson	PROPN
admet-184	279	11	,	,	PUNCT
admet-184	279	12	w.h	w.h	PROPN
admet-184	279	13	.	.	PROPN
admet-184	279	14	frey	frey	PROPN
admet-184	279	15	,	,	PUNCT
admet-184	279	16	2nd	2nd	PROPN
admet-184	279	17	,	,	PUNCT
admet-184	279	18	l.d	l.d	PROPN
admet-184	279	19	.	.	PROPN
admet-184	279	20	baker	baker	PROPN
admet-184	279	21	,	,	PUNCT
admet-184	279	22	b.	b.	PROPN
admet-184	279	23	cholerton	cholerton	PROPN
admet-184	279	24	,	,	PUNCT
admet-184	279	25	m.l	m.l	PROPN
admet-184	279	26	.	.	PROPN
admet-184	279	27	keeling	keeling	PROPN
admet-184	279	28	,	,	PUNCT
admet-184	279	29	d.a	d.a	PROPN
admet-184	279	30	.	.	PROPN
admet-184	279	31	belongia	belongia	NOUN
admet-184	279	32	,	,	PUNCT
admet-184	279	33	m.a	m.a	PROPN
admet-184	279	34	.	.	PROPN
admet-184	279	35	fishel	fishel	PROPN
admet-184	279	36	,	,	PUNCT
admet-184	279	37	s.r	s.r	PROPN
admet-184	279	38	.	.	PROPN
admet-184	279	39	plymate	plymate	PROPN
admet-184	279	40	,	,	PUNCT
admet-184	279	41	g.d	g.d	PROPN
admet-184	279	42	.	.	PROPN
admet-184	279	43	schellenberg	schellenberg	PROPN
admet-184	279	44	,	,	PUNCT
admet-184	279	45	m.m	m.m	PROPN
admet-184	279	46	.	.	PROPN
admet-184	279	47	cherrier	cherrier	PROPN
admet-184	279	48	,	,	PUNCT
admet-184	279	49	s.	s.	PROPN
admet-184	279	50	craft	craft	PROPN
admet-184	279	51	,	,	PUNCT
admet-184	279	52	neurobiology	neurobiology	NOUN
admet-184	279	53	of	of	ADP
admet-184	279	54	aging	age	VERB
admet-184	279	55	27	27	NUM
admet-184	279	56	(	(	PUNCT
admet-184	279	57	2006	2006	NUM
admet-184	279	58	)	)	PUNCT
admet-184	279	59	451	451	NUM
admet-184	279	60	-	-	SYM
admet-184	279	61	458	458	NUM
admet-184	279	62	.	.	PUNCT
admet-184	280	1	[	[	X
admet-184	280	2	52	52	NUM
admet-184	280	3	]	]	PUNCT
admet-184	281	1	j.	j.	PROPN
admet-184	281	2	born	bear	VERB
admet-184	281	3	,	,	PUNCT
admet-184	281	4	t.	t.	NOUN
admet-184	281	5	lange	lange	PROPN
admet-184	281	6	,	,	PUNCT
admet-184	281	7	w.	w.	PROPN
admet-184	281	8	kern	kern	PROPN
admet-184	281	9	,	,	PUNCT
admet-184	281	10	g.p	g.p	PROPN
admet-184	281	11	.	.	PROPN
admet-184	281	12	mcgregor	mcgregor	PROPN
admet-184	281	13	,	,	PUNCT
admet-184	281	14	u.	u.	PROPN
admet-184	281	15	bickel	bickel	PROPN
admet-184	281	16	,	,	PUNCT
admet-184	281	17	h.l	h.l	PROPN
admet-184	281	18	.	.	PROPN
admet-184	281	19	fehm	fehm	PROPN
admet-184	281	20	,	,	PUNCT
admet-184	281	21	nature	nature	NOUN
admet-184	281	22	neuroscience	neuroscience	NOUN
admet-184	281	23	5	5	NUM
admet-184	281	24	(	(	PUNCT
admet-184	281	25	2002	2002	NUM
admet-184	281	26	)	)	PUNCT
admet-184	281	27	514516	514516	NUM
admet-184	281	28	.	.	PUNCT
admet-184	282	1	[	[	X
admet-184	282	2	53	53	NUM
admet-184	282	3	]	]	PUNCT
admet-184	282	4	w.	w.	PROPN
admet-184	282	5	kern	kern	PROPN
admet-184	282	6	,	,	PUNCT
admet-184	282	7	j.	j.	PROPN
admet-184	282	8	born	bear	VERB
admet-184	282	9	,	,	PUNCT
admet-184	282	10	h.	h.	PROPN
admet-184	282	11	schreiber	schreiber	PROPN
admet-184	282	12	,	,	PUNCT
admet-184	282	13	h.l	h.l	PROPN
admet-184	282	14	.	.	PROPN
admet-184	282	15	fehm	fehm	PROPN
admet-184	282	16	,	,	PUNCT
admet-184	282	17	diabetes	diabete	VERB
admet-184	282	18	48	48	NUM
admet-184	282	19	(	(	PUNCT
admet-184	282	20	1999	1999	NUM
admet-184	282	21	)	)	PUNCT
admet-184	282	22	557	557	NUM
admet-184	282	23	-	-	SYM
admet-184	282	24	563	563	NUM
admet-184	282	25	.	.	PUNCT
admet-184	283	1	[	[	X
admet-184	283	2	54	54	NUM
admet-184	283	3	]	]	X
admet-184	283	4	c.	c.	PROPN
admet-184	283	5	benedict	benedict	PROPN
admet-184	283	6	,	,	PUNCT
admet-184	283	7	s.	s.	PROPN
admet-184	283	8	brede	brede	PROPN
admet-184	283	9	,	,	PUNCT
admet-184	283	10	h.b	h.b	PROPN
admet-184	283	11	.	.	PROPN
admet-184	283	12	schioth	schioth	PROPN
admet-184	283	13	,	,	PUNCT
admet-184	283	14	h.	h.	PROPN
admet-184	283	15	lehnert	lehnert	PROPN
admet-184	283	16	,	,	PUNCT
admet-184	283	17	b.	b.	PROPN
admet-184	283	18	schultes	schultes	PROPN
admet-184	283	19	,	,	PUNCT
admet-184	283	20	j.	j.	PROPN
admet-184	283	21	born	bear	VERB
admet-184	283	22	,	,	PUNCT
admet-184	283	23	m.	m.	NOUN
admet-184	283	24	hallschmid	hallschmid	PROPN
admet-184	283	25	,	,	PUNCT
admet-184	283	26	diabetes	diabetes	NOUN
admet-184	283	27	60	60	NUM
admet-184	283	28	(	(	PUNCT
admet-184	283	29	2011	2011	NUM
admet-184	283	30	)	)	PUNCT
admet-184	283	31	114	114	NUM
admet-184	283	32	-	-	SYM
admet-184	283	33	118	118	NUM
admet-184	283	34	.	.	PUNCT
admet-184	284	1	[	[	X
admet-184	284	2	55	55	NUM
admet-184	284	3	]	]	X
admet-184	284	4	c.	c.	PROPN
admet-184	284	5	benedict	benedict	PROPN
admet-184	284	6	,	,	PUNCT
admet-184	284	7	w.	w.	PROPN
admet-184	284	8	kern	kern	PROPN
admet-184	284	9	,	,	PUNCT
admet-184	284	10	b.	b.	PROPN
admet-184	284	11	schultes	schultes	PROPN
admet-184	284	12	,	,	PUNCT
admet-184	284	13	j.	j.	PROPN
admet-184	284	14	born	bear	VERB
admet-184	284	15	,	,	PUNCT
admet-184	284	16	m.	m.	NOUN
admet-184	284	17	hallschmid	hallschmid	PROPN
admet-184	284	18	,	,	PUNCT
admet-184	284	19	the	the	DET
admet-184	284	20	journal	journal	NOUN
admet-184	284	21	of	of	ADP
admet-184	284	22	clinical	clinical	ADJ
admet-184	284	23	endocrinology	endocrinology	NOUN
admet-184	284	24	and	and	CCONJ
admet-184	284	25	metabolism	metabolism	NOUN
admet-184	284	26	93	93	NUM
admet-184	284	27	(	(	PUNCT
admet-184	284	28	2008	2008	NUM
admet-184	284	29	)	)	PUNCT
admet-184	284	30	1339	1339	NUM
admet-184	284	31	-	-	SYM
admet-184	284	32	1344	1344	NUM
admet-184	284	33	.	.	PUNCT
admet-184	285	1	[	[	X
admet-184	285	2	56	56	NUM
admet-184	285	3	]	]	X
admet-184	285	4	m.a	m.a	PROPN
admet-184	285	5	.	.	PROPN
admet-184	285	6	reger	reger	PROPN
admet-184	285	7	,	,	PUNCT
admet-184	285	8	g.s	g.s	PROPN
admet-184	285	9	.	.	PROPN
admet-184	285	10	watson	watson	PROPN
admet-184	285	11	,	,	PUNCT
admet-184	285	12	p.s	p.s	PROPN
admet-184	285	13	.	.	PROPN
admet-184	285	14	green	green	PROPN
admet-184	285	15	,	,	PUNCT
admet-184	285	16	c.w	c.w	PROPN
admet-184	285	17	.	.	PROPN
admet-184	285	18	wilkinson	wilkinson	PROPN
admet-184	285	19	,	,	PUNCT
admet-184	285	20	l.d	l.d	PROPN
admet-184	285	21	.	.	PROPN
admet-184	285	22	baker	baker	PROPN
admet-184	285	23	,	,	PUNCT
admet-184	285	24	b.	b.	PROPN
admet-184	285	25	cholerton	cholerton	PROPN
admet-184	285	26	,	,	PUNCT
admet-184	285	27	m.a	m.a	PROPN
admet-184	285	28	.	.	PROPN
admet-184	285	29	fishel	fishel	PROPN
admet-184	285	30	,	,	PUNCT
admet-184	285	31	s.r	s.r	PROPN
admet-184	285	32	.	.	PROPN
admet-184	285	33	plymate	plymate	PROPN
admet-184	285	34	,	,	PUNCT
admet-184	285	35	j.c	j.c	PROPN
admet-184	285	36	.	.	PROPN
admet-184	285	37	breitner	breitner	PROPN
admet-184	285	38	,	,	PUNCT
admet-184	285	39	w.	w.	PROPN
admet-184	285	40	degroodt	degroodt	PROPN
admet-184	285	41	,	,	PUNCT
admet-184	285	42	p.	p.	PROPN
admet-184	285	43	mehta	mehta	PROPN
admet-184	285	44	,	,	PUNCT
admet-184	285	45	s.	s.	PROPN
admet-184	285	46	craft	craft	PROPN
admet-184	285	47	,	,	PUNCT
admet-184	285	48	neurology	neurology	NOUN
admet-184	285	49	70	70	NUM
admet-184	285	50	(	(	PUNCT
admet-184	285	51	2008	2008	NUM
admet-184	285	52	)	)	PUNCT
admet-184	285	53	440	440	NUM
admet-184	285	54	-	-	SYM
admet-184	285	55	448	448	NUM
admet-184	285	56	.	.	PUNCT
admet-184	286	1	[	[	X
admet-184	286	2	57	57	NUM
admet-184	286	3	]	]	PUNCT
admet-184	286	4	e.	e.	PROPN
admet-184	286	5	mori	mori	PROPN
admet-184	286	6	,	,	PUNCT
admet-184	286	7	c.	c.	PROPN
admet-184	286	8	merkonidis	merkonidis	PROPN
admet-184	286	9	,	,	PUNCT
admet-184	286	10	m.	m.	NOUN
admet-184	286	11	cuevas	cuevas	PROPN
admet-184	286	12	,	,	PUNCT
admet-184	286	13	v.	v.	ADP
admet-184	286	14	gudziol	gudziol	NOUN
admet-184	286	15	,	,	PUNCT
admet-184	286	16	y.	y.	PROPN
admet-184	286	17	matsuwaki	matsuwaki	PROPN
admet-184	286	18	,	,	PUNCT
admet-184	286	19	t.	t.	PROPN
admet-184	286	20	hummel	hummel	PROPN
admet-184	286	21	,	,	PUNCT
admet-184	286	22	european	european	ADJ
admet-184	286	23	archives	archive	NOUN
admet-184	286	24	of	of	ADP
admet-184	286	25	otorhino	otorhino	NOUN
admet-184	286	26	-	-	PUNCT
admet-184	286	27	laryngology	laryngology	NOUN
admet-184	286	28	272	272	NUM
admet-184	286	29	(	(	PUNCT
admet-184	286	30	2015	2015	NUM
admet-184	286	31	)	)	PUNCT
admet-184	286	32	doi:10.1007	doi:10.1007	NOUN
admet-184	286	33	/	/	SYM
admet-184	286	34	s00405	s00405	PROPN
admet-184	286	35	-	-	PUNCT
admet-184	286	36	015	015	NUM
admet-184	286	37	-	-	PUNCT
admet-184	286	38	3701	3701	NUM
admet-184	286	39	-	-	PUNCT
admet-184	286	40	y.	y.	NOUN
admet-184	286	41	[	[	X
admet-184	286	42	58	58	NUM
admet-184	286	43	]	]	X
admet-184	286	44	a.c	a.c	PROPN
admet-184	286	45	.	.	PROPN
admet-184	286	46	leary	leary	PROPN
admet-184	286	47	,	,	PUNCT
admet-184	286	48	m.	m.	NOUN
admet-184	286	49	dowling	dowling	PROPN
admet-184	286	50	,	,	PUNCT
admet-184	286	51	k.	k.	PROPN
admet-184	286	52	cussen	cussen	PROPN
admet-184	286	53	,	,	PUNCT
admet-184	286	54	j.	j.	PROPN
admet-184	286	55	o'brien	o'brien	PROPN
admet-184	286	56	,	,	PUNCT
admet-184	286	57	r.m	r.m	PROPN
admet-184	286	58	.	.	PROPN
admet-184	286	59	stote	stote	PROPN
admet-184	286	60	,	,	PUNCT
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admet-184	286	64	science	science	NOUN
admet-184	286	65	and	and	CCONJ
admet-184	286	66	technology	technology	NOUN
admet-184	286	67	2	2	NUM
admet-184	286	68	(	(	PUNCT
admet-184	286	69	2008	2008	NUM
admet-184	286	70	)	)	PUNCT
admet-184	286	71	1054	1054	NUM
admet-184	286	72	-	-	SYM
admet-184	286	73	1060	1060	NUM
admet-184	286	74	.	.	PUNCT
admet-184	287	1	[	[	X
admet-184	287	2	59	59	NUM
admet-184	287	3	]	]	PUNCT
admet-184	287	4	s.	s.	PROPN
admet-184	287	5	gancheva	gancheva	PROPN
admet-184	287	6	,	,	PUNCT
admet-184	287	7	c.	c.	PROPN
admet-184	287	8	koliaki	koliaki	PROPN
admet-184	287	9	,	,	PUNCT
admet-184	287	10	a.	a.	NOUN
admet-184	287	11	bierwagen	bierwagen	NOUN
admet-184	287	12	,	,	PUNCT
admet-184	287	13	p.	p.	PROPN
admet-184	287	14	nowotny	nowotny	PROPN
admet-184	287	15	,	,	PUNCT
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admet-184	287	17	heni	heni	PROPN
admet-184	287	18	,	,	PUNCT
admet-184	287	19	a.	a.	NOUN
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admet-184	287	21	,	,	PUNCT
admet-184	287	22	h.-u	h.-u	NOUN
admet-184	287	23	.	.	PUNCT
admet-184	288	1	häring	häre	VERB
admet-184	288	2	,	,	PUNCT
admet-184	288	3	j.	j.	PROPN
admet-184	288	4	szendroedi	szendroedi	PROPN
admet-184	288	5	,	,	PUNCT
admet-184	288	6	m.	m.	NOUN
admet-184	288	7	roden	roden	PROPN
admet-184	288	8	,	,	PUNCT
admet-184	288	9	diabetes	diabete	VERB
admet-184	288	10	64	64	NUM
admet-184	288	11	(	(	PUNCT
admet-184	288	12	2015	2015	NUM
admet-184	288	13	)	)	PUNCT
admet-184	288	14	1966	1966	NUM
admet-184	288	15	-	-	SYM
admet-184	288	16	1975	1975	NUM
admet-184	288	17	.	.	PUNCT
admet-184	289	1	[	[	X
admet-184	289	2	60	60	NUM
admet-184	289	3	]	]	X
admet-184	289	4	m.s	m.s	PROPN
admet-184	289	5	.	.	PROPN
admet-184	289	6	dhamoon	dhamoon	PROPN
admet-184	289	7	,	,	PUNCT
admet-184	289	8	j.m	j.m	PROPN
admet-184	289	9	.	.	PROPN
admet-184	289	10	noble	noble	PROPN
admet-184	289	11	,	,	PUNCT
admet-184	289	12	s.	s.	PROPN
admet-184	289	13	craft	craft	PROPN
admet-184	289	14	,	,	PUNCT
admet-184	289	15	neurology	neurology	NOUN
admet-184	289	16	72	72	NUM
admet-184	289	17	(	(	PUNCT
admet-184	289	18	2009	2009	NUM
admet-184	289	19	)	)	PUNCT
admet-184	289	20	292	292	NUM
admet-184	289	21	-	-	SYM
admet-184	289	22	293	293	NUM
admet-184	289	23	;	;	PUNCT
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admet-184	289	25	reply	reply	VERB
admet-184	289	26	293	293	NUM
admet-184	289	27	-	-	SYM
admet-184	289	28	294	294	NUM
admet-184	289	29	.	.	PUNCT
admet-184	290	1	[	[	X
admet-184	290	2	61	61	NUM
admet-184	290	3	]	]	PUNCT
admet-184	290	4	s.	s.	PROPN
admet-184	290	5	craft	craft	PROPN
admet-184	290	6	,	,	PUNCT
admet-184	290	7	l.d	l.d	PROPN
admet-184	290	8	.	.	PROPN
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admet-184	290	10	,	,	PUNCT
admet-184	290	11	t.j	t.j	PROPN
admet-184	290	12	.	.	PROPN
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admet-184	290	14	,	,	PUNCT
admet-184	290	15	s.	s.	PROPN
admet-184	290	16	minoshima	minoshima	PROPN
admet-184	290	17	,	,	PUNCT
admet-184	290	18	g.s	g.s	PROPN
admet-184	290	19	.	.	PROPN
admet-184	290	20	watson	watson	PROPN
admet-184	290	21	,	,	PUNCT
admet-184	290	22	a.	a.	PROPN
admet-184	290	23	claxton	claxton	PROPN
admet-184	290	24	,	,	PUNCT
admet-184	290	25	m.	m.	PROPN
admet-184	290	26	arbuckle	arbuckle	PROPN
admet-184	290	27	,	,	PUNCT
admet-184	290	28	m.	m.	PROPN
admet-184	290	29	callaghan	callaghan	PROPN
admet-184	290	30	,	,	PUNCT
admet-184	290	31	e.	e.	PROPN
admet-184	290	32	tsai	tsai	PROPN
admet-184	290	33	,	,	PUNCT
admet-184	290	34	s.r	s.r	PROPN
admet-184	290	35	.	.	PROPN
admet-184	290	36	plymate	plymate	PROPN
admet-184	290	37	,	,	PUNCT
admet-184	290	38	p.s	p.s	PROPN
admet-184	290	39	.	.	PROPN
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admet-184	290	41	,	,	PUNCT
admet-184	290	42	j.	j.	PROPN
admet-184	290	43	leverenz	leverenz	PROPN
admet-184	290	44	,	,	PUNCT
admet-184	290	45	d.	d.	PROPN
admet-184	290	46	cross	cross	PROPN
admet-184	290	47	,	,	PUNCT
admet-184	290	48	b.	b.	PROPN
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admet-184	290	50	,	,	PUNCT
admet-184	290	51	archives	archive	NOUN
admet-184	290	52	of	of	ADP
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admet-184	290	54	69	69	NUM
admet-184	290	55	(	(	PUNCT
admet-184	290	56	2012	2012	NUM
admet-184	290	57	)	)	PUNCT
admet-184	290	58	29	29	NUM
admet-184	290	59	-	-	SYM
admet-184	290	60	38	38	NUM
admet-184	290	61	.	.	PUNCT
admet-184	291	1	[	[	X
admet-184	291	2	62	62	NUM
admet-184	291	3	]	]	PUNCT
admet-184	291	4	a.	a.	NOUN
admet-184	291	5	claxton	claxton	PROPN
admet-184	291	6	,	,	PUNCT
admet-184	291	7	l.d	l.d	PROPN
admet-184	291	8	.	.	PROPN
admet-184	291	9	baker	baker	PROPN
admet-184	291	10	,	,	PUNCT
admet-184	291	11	a.	a.	PROPN
admet-184	291	12	hanson	hanson	PROPN
admet-184	291	13	,	,	PUNCT
admet-184	291	14	e.h	e.h	PROPN
admet-184	291	15	.	.	PROPN
admet-184	291	16	trittschuh	trittschuh	PROPN
admet-184	291	17	,	,	PUNCT
admet-184	291	18	b.	b.	PROPN
admet-184	291	19	cholerton	cholerton	PROPN
admet-184	291	20	,	,	PUNCT
admet-184	291	21	a.	a.	PROPN
admet-184	291	22	morgan	morgan	PROPN
admet-184	291	23	,	,	PUNCT
admet-184	291	24	m.	m.	PROPN
admet-184	291	25	callaghan	callaghan	PROPN
admet-184	291	26	,	,	PUNCT
admet-184	291	27	m.	m.	PROPN
admet-184	291	28	arbuckle	arbuckle	PROPN
admet-184	291	29	,	,	PUNCT
admet-184	291	30	c.	c.	PROPN
admet-184	291	31	behl	behl	PROPN
admet-184	291	32	,	,	PUNCT
admet-184	291	33	s.	s.	PROPN
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admet-184	291	35	,	,	PUNCT
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admet-184	291	37	of	of	ADP
admet-184	291	38	alzheimer	alzheimer	PROPN
admet-184	291	39	's	's	PART
admet-184	291	40	disease	disease	NOUN
admet-184	291	41	:	:	PUNCT
admet-184	291	42	jad	jad	PROPN
admet-184	291	43	44	44	NUM
admet-184	291	44	(	(	PUNCT
admet-184	291	45	2015	2015	NUM
admet-184	291	46	)	)	PUNCT
admet-184	291	47	897	897	NUM
admet-184	291	48	-	-	SYM
admet-184	291	49	906	906	NUM
admet-184	291	50	.	.	PUNCT
admet-184	292	1	[	[	X
admet-184	292	2	63	63	NUM
admet-184	292	3	]	]	X
admet-184	292	4	w.a	w.a	PROPN
admet-184	292	5	.	.	PROPN
admet-184	292	6	banks	bank	NOUN
admet-184	292	7	,	,	PUNCT
admet-184	292	8	j.e	j.e	PROPN
admet-184	292	9	.	.	PROPN
admet-184	292	10	morley	morley	PROPN
admet-184	292	11	,	,	PUNCT
admet-184	292	12	j.l	j.l	PROPN
admet-184	292	13	.	.	PROPN
admet-184	292	14	lynch	lynch	PROPN
admet-184	292	15	,	,	PUNCT
admet-184	292	16	k.m	k.m	PROPN
admet-184	292	17	.	.	PROPN
admet-184	292	18	lynch	lynch	PROPN
admet-184	292	19	,	,	PUNCT
admet-184	292	20	a.d	a.d	PROPN
admet-184	292	21	.	.	PROPN
admet-184	292	22	mooradian	mooradian	PROPN
admet-184	292	23	,	,	PUNCT
admet-184	292	24	peptides	peptide	NOUN
admet-184	292	25	31	31	NUM
admet-184	292	26	(	(	PUNCT
admet-184	292	27	2010	2010	NUM
admet-184	292	28	)	)	PUNCT
admet-184	292	29	2284	2284	NUM
admet-184	292	30	-	-	SYM
admet-184	292	31	2288	2288	NUM
admet-184	292	32	.	.	PUNCT
admet-184	293	1	[	[	X
admet-184	293	2	64	64	NUM
admet-184	293	3	]	]	PUNCT
admet-184	293	4	v.	v.	CCONJ
admet-184	293	5	novak	novak	PROPN
admet-184	293	6	,	,	PUNCT
admet-184	293	7	w.	w.	PROPN
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admet-184	293	9	,	,	PUNCT
admet-184	293	10	y.	y.	PROPN
admet-184	293	11	hao	hao	PROPN
admet-184	293	12	,	,	PUNCT
admet-184	293	13	m.	m.	NOUN
admet-184	293	14	munshi	munshi	PROPN
admet-184	293	15	,	,	PUNCT
admet-184	293	16	p.	p.	PROPN
admet-184	293	17	novak	novak	PROPN
admet-184	293	18	,	,	PUNCT
admet-184	293	19	a.	a.	PROPN
admet-184	293	20	galica	galica	PROPN
admet-184	293	21	,	,	PUNCT
admet-184	293	22	b.	b.	PROPN
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admet-184	293	24	,	,	PUNCT
admet-184	293	25	p.	p.	PROPN
admet-184	293	26	roberson	roberson	PROPN
admet-184	293	27	,	,	PUNCT
admet-184	293	28	s.	s.	PROPN
admet-184	293	29	craft	craft	PROPN
admet-184	293	30	,	,	PUNCT
admet-184	293	31	a.	a.	NOUN
admet-184	293	32	abduljalil	abduljalil	PROPN
admet-184	293	33	,	,	PUNCT
admet-184	293	34	diabetes	diabetes	NOUN
admet-184	293	35	care	care	VERB
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admet-184	293	37	(	(	PUNCT
admet-184	293	38	2014	2014	NUM
admet-184	293	39	)	)	PUNCT
admet-184	293	40	751	751	NUM
admet-184	293	41	-	-	SYM
admet-184	293	42	759	759	NUM
admet-184	293	43	.	.	PUNCT
admet-184	294	1	[	[	X
admet-184	294	2	65	65	NUM
admet-184	294	3	]	]	X
admet-184	294	4	h.	h.	PROPN
admet-184	294	5	zhang	zhang	PROPN
admet-184	294	6	,	,	PUNCT
admet-184	294	7	y.	y.	PROPN
admet-184	294	8	hao	hao	PROPN
admet-184	294	9	,	,	PUNCT
admet-184	294	10	b.	b.	PROPN
admet-184	294	11	manor	manor	PROPN
admet-184	294	12	,	,	PUNCT
admet-184	294	13	p.	p.	PROPN
admet-184	294	14	novak	novak	PROPN
admet-184	294	15	,	,	PUNCT
admet-184	294	16	w.	w.	PROPN
admet-184	294	17	milberg	milberg	PROPN
admet-184	294	18	,	,	PUNCT
admet-184	294	19	j.	j.	PROPN
admet-184	294	20	zhang	zhang	PROPN
admet-184	294	21	,	,	PUNCT
admet-184	294	22	j.	j.	PROPN
admet-184	294	23	fang	fang	PROPN
admet-184	294	24	,	,	PUNCT
admet-184	294	25	v.	v.	CCONJ
admet-184	294	26	novak	novak	PROPN
admet-184	294	27	,	,	PUNCT
admet-184	294	28	diabetes	diabetes	NOUN
admet-184	294	29	64	64	NUM
admet-184	294	30	(	(	PUNCT
admet-184	294	31	2015	2015	NUM
admet-184	294	32	)	)	PUNCT
admet-184	294	33	1025	1025	NUM
admet-184	294	34	-	-	SYM
admet-184	294	35	1034	1034	NUM
admet-184	294	36	.	.	PUNCT
admet-184	295	1	[	[	X
admet-184	295	2	66	66	NUM
admet-184	295	3	]	]	PUNCT
admet-184	295	4	m.	m.	NOUN
admet-184	295	5	heni	heni	PROPN
admet-184	295	6	,	,	PUNCT
admet-184	295	7	r.	r.	PROPN
admet-184	295	8	wagner	wagner	PROPN
admet-184	295	9	,	,	PUNCT
admet-184	295	10	s.	s.	PROPN
admet-184	295	11	kullmann	kullmann	PROPN
admet-184	295	12	,	,	PUNCT
admet-184	295	13	r.	r.	PROPN
admet-184	295	14	veit	veit	PROPN
admet-184	295	15	,	,	PUNCT
admet-184	295	16	h.	h.	PROPN
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admet-184	295	19	,	,	PUNCT
admet-184	295	20	k.	k.	PROPN
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admet-184	295	22	,	,	PUNCT
admet-184	295	23	c.	c.	PROPN
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admet-184	295	25	,	,	PUNCT
admet-184	295	26	a.	a.	PROPN
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admet-184	295	28	,	,	PUNCT
admet-184	295	29	n.	n.	PROPN
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admet-184	295	31	,	,	PUNCT
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admet-184	295	33	.	.	PUNCT
admet-184	296	1	häring	häre	VERB
admet-184	296	2	,	,	PUNCT
admet-184	296	3	h.	h.	PROPN
admet-184	296	4	preissl	preissl	PROPN
admet-184	296	5	,	,	PUNCT
admet-184	296	6	a.	a.	NOUN
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admet-184	296	8	,	,	PUNCT
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admet-184	296	11	(	(	PUNCT
admet-184	296	12	2014	2014	NUM
admet-184	296	13	)	)	PUNCT
admet-184	296	14	4083	4083	NUM
admet-184	296	15	-	-	SYM
admet-184	296	16	4088	4088	NUM
admet-184	296	17	.	.	PUNCT
admet-184	297	1	[	[	X
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admet-184	297	3	]	]	PUNCT
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admet-184	297	10	,	,	PUNCT
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admet-184	297	20	(	(	PUNCT
admet-184	297	21	04/28/2015	04/28/2015	NUM
admet-184	297	22	)	)	PUNCT
admet-184	297	23	.	.	PUNCT
admet-184	298	1	[	[	X
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admet-184	298	3	]	]	PUNCT
admet-184	298	4	s.	s.	PROPN
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admet-184	298	10	,	,	PUNCT
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admet-184	298	14	k.	k.	PROPN
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admet-184	298	16	,	,	PUNCT
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admet-184	298	20	reviews	review	VERB
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admet-184	298	22	(	(	PUNCT
admet-184	298	23	2007	2007	NUM
admet-184	298	24	)	)	PUNCT
admet-184	298	25	15211546	15211546	NUM
admet-184	298	26	.	.	PUNCT
admet-184	299	1	[	[	X
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admet-184	299	3	]	]	PUNCT
admet-184	299	4	s.	s.	PROPN
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admet-184	299	9	,	,	PUNCT
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admet-184	299	12	therapy	therapy	NOUN
admet-184	299	13	6	6	NUM
admet-184	299	14	(	(	PUNCT
admet-184	299	15	2012	2012	NUM
admet-184	299	16	)	)	PUNCT
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admet-184	299	18	.	.	PUNCT
admet-184	300	1	[	[	X
admet-184	300	2	70	70	NUM
admet-184	300	3	]	]	X
admet-184	300	4	k.	k.	PROPN
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admet-184	300	6	,	,	PUNCT
admet-184	300	7	m.c	m.c	PROPN
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admet-184	300	23	drug	drug	NOUN
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admet-184	300	26	(	(	PUNCT
admet-184	300	27	2015	2015	NUM
admet-184	300	28	)	)	PUNCT
admet-184	300	29	59	59	NUM
admet-184	300	30	-	-	SYM
admet-184	300	31	67	67	NUM
admet-184	300	32	.	.	PUNCT
admet-184	301	1	[	[	X
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admet-184	301	4	p.g	p.g	PROPN
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admet-184	301	7	,	,	PUNCT
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admet-184	301	10	(	(	PUNCT
admet-184	301	11	2008	2008	NUM
admet-184	301	12	)	)	PUNCT
admet-184	301	13	864	864	NUM
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admet-184	301	18	.	.	PUNCT
admet-184	302	1	[	[	X
admet-184	302	2	72	72	NUM
admet-184	302	3	]	]	PUNCT
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admet-184	302	6	:	:	PUNCT
admet-184	302	7	a	a	DET
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admet-184	302	10	:	:	PUNCT
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admet-184	302	15	dispersiontm	dispersiontm	X
admet-184	302	16	(	(	PUNCT
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admet-184	302	18	)	)	PUNCT
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admet-184	302	21	pump	pump	NOUN
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admet-184	302	23	nebulizer	nebulizer	NOUN
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admet-184	302	26	,	,	PUNCT
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admet-184	302	28	.	.	PUNCT
admet-184	303	1	[	[	X
admet-184	303	2	73	73	NUM
admet-184	303	3	]	]	X
admet-184	303	4	p.g	p.g	PROPN
admet-184	303	5	.	.	PROPN
admet-184	303	6	djupesland	djupesland	PROPN
admet-184	303	7	,	,	PUNCT
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admet-184	303	9	skretting	skretting	PROPN
admet-184	303	10	,	,	PUNCT
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admet-184	303	15	holand	holand	PROPN
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admet-184	303	17	the	the	DET
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admet-184	303	20	(	(	PUNCT
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admet-184	303	22	)	)	PUNCT
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admet-184	303	24	-	-	SYM
admet-184	303	25	472	472	NUM
admet-184	303	26	.	.	PUNCT
admet-184	304	1	http://www.clinicaltrials.gov/ct2/show/results/nct01145482	http://www.clinicaltrials.gov/ct2/show/results/nct01145482	PROPN
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admet-184	304	3	m.	m.	NOUN
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admet-184	304	5	,	,	PUNCT
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admet-184	304	8	,	,	PUNCT
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admet-184	304	12	k.	k.	PROPN
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admet-184	304	17	3(3	3(3	NUM
admet-184	304	18	)	)	PUNCT
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admet-184	304	20	2015	2015	NUM
admet-184	304	21	)	)	PUNCT
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admet-184	304	23	-	-	SYM
admet-184	304	24	202	202	NUM
admet-184	304	25	202	202	NUM
admet-184	305	1	[	[	X
admet-184	305	2	74	74	NUM
admet-184	305	3	]	]	X
admet-184	305	4	p.g	p.g	PROPN
admet-184	305	5	.	.	PROPN
admet-184	305	6	djupesland	djupesland	PROPN
admet-184	305	7	,	,	PUNCT
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admet-184	305	9	skretting	skretting	PROPN
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admet-184	305	14	t.	t.	PROPN
admet-184	305	15	holand	holand	PROPN
admet-184	305	16	,	,	PUNCT
admet-184	305	17	journal	journal	NOUN
admet-184	305	18	of	of	ADP
admet-184	305	19	aerosol	aerosol	NOUN
admet-184	305	20	medicine	medicine	NOUN
admet-184	305	21	17	17	NUM
admet-184	305	22	(	(	PUNCT
admet-184	305	23	2004	2004	NUM
admet-184	305	24	)	)	PUNCT
admet-184	305	25	249259	249259	NUM
admet-184	305	26	.	.	PUNCT
admet-184	306	1	[	[	X
admet-184	306	2	75	75	NUM
admet-184	306	3	]	]	X
admet-184	306	4	j.d	j.d	PROPN
admet-184	306	5	.	.	PROPN
admet-184	306	6	hoekman	hoekman	PROPN
admet-184	306	7	,	,	PUNCT
admet-184	306	8	r.j	r.j	PROPN
admet-184	306	9	.	.	PROPN
admet-184	306	10	ho	ho	PROPN
admet-184	306	11	,	,	PUNCT
admet-184	306	12	anesthesia	anesthesia	PROPN
admet-184	306	13	and	and	CCONJ
admet-184	306	14	analgesia	analgesia	PROPN
admet-184	306	15	113	113	NUM
admet-184	306	16	(	(	PUNCT
admet-184	306	17	2011	2011	NUM
admet-184	306	18	)	)	PUNCT
admet-184	306	19	641	641	NUM
admet-184	306	20	.	.	PUNCT
admet-184	307	1	[	[	X
admet-184	307	2	76	76	NUM
admet-184	307	3	]	]	X
admet-184	307	4	a.	a.	NOUN
admet-184	307	5	kupila	kupila	PROPN
admet-184	307	6	,	,	PUNCT
admet-184	307	7	j.	j.	PROPN
admet-184	307	8	sipila	sipila	PROPN
admet-184	307	9	,	,	PUNCT
admet-184	307	10	p.	p.	PROPN
admet-184	307	11	keskinen	keskinen	PROPN
admet-184	307	12	,	,	PUNCT
admet-184	307	13	t.	t.	PROPN
admet-184	307	14	simell	simell	PROPN
admet-184	307	15	,	,	PUNCT
admet-184	307	16	m.	m.	NOUN
admet-184	307	17	knip	knip	NOUN
admet-184	307	18	,	,	PUNCT
admet-184	307	19	k.	k.	PROPN
admet-184	307	20	pulkki	pulkki	PROPN
admet-184	307	21	,	,	PUNCT
admet-184	307	22	o.	o.	PROPN
admet-184	307	23	simell	simell	PROPN
admet-184	307	24	,	,	PUNCT
admet-184	307	25	diabetes	diabetes	NOUN
admet-184	307	26	/	/	SYM
admet-184	307	27	metabolism	metabolism	NOUN
admet-184	307	28	research	research	NOUN
admet-184	307	29	and	and	CCONJ
admet-184	307	30	reviews	review	NOUN
admet-184	307	31	19	19	NUM
admet-184	307	32	(	(	PUNCT
admet-184	307	33	2003	2003	NUM
admet-184	307	34	)	)	PUNCT
admet-184	307	35	415	415	NUM
admet-184	307	36	-	-	SYM
admet-184	307	37	420	420	NUM
admet-184	307	38	.	.	PUNCT
admet-184	308	1	[	[	X
admet-184	308	2	77	77	NUM
admet-184	308	3	]	]	X
admet-184	308	4	cpex	cpex	NOUN
admet-184	308	5	pharmaceuticals	pharmaceutical	NOUN
admet-184	308	6	announces	announce	VERB
admet-184	308	7	preliminary	preliminary	ADJ
admet-184	308	8	results	result	NOUN
admet-184	308	9	from	from	ADP
admet-184	308	10	its	its	PRON
admet-184	308	11	phase	phase	NOUN
admet-184	308	12	2a	2a	NUM
admet-184	308	13	clinical	clinical	ADJ
admet-184	308	14	trial	trial	NOUN
admet-184	308	15	of	of	ADP
admet-184	308	16	nasulin	nasulin	NOUN
admet-184	308	17	,	,	PUNCT
admet-184	308	18	http://www.bloomberg.com/apps/news?pid=newsarchive&sid=af8dtg4w0xt4	http://www.bloomberg.com/apps/news?pid=newsarchive&sid=af8dtg4w0xt4	PROPN
admet-184	308	19	(	(	PUNCT
admet-184	308	20	03/31/2015	03/31/2015	NUM
admet-184	308	21	)	)	PUNCT
admet-184	308	22	.	.	PUNCT
admet-184	309	1	[	[	X
admet-184	309	2	78	78	NUM
admet-184	309	3	]	]	X
admet-184	309	4	s.	s.	PROPN
admet-184	309	5	dash	dash	PROPN
admet-184	309	6	,	,	PUNCT
admet-184	309	7	c.	c.	PROPN
admet-184	309	8	xiao	xiao	PROPN
admet-184	309	9	,	,	PUNCT
admet-184	309	10	c.	c.	PROPN
admet-184	309	11	morgantini	morgantini	PROPN
admet-184	309	12	,	,	PUNCT
admet-184	309	13	k.	k.	PROPN
admet-184	309	14	koulajian	koulajian	PROPN
admet-184	309	15	,	,	PUNCT
admet-184	309	16	g.f	g.f	PROPN
admet-184	309	17	.	.	PROPN
admet-184	309	18	lewis	lewis	PROPN
admet-184	309	19	,	,	PUNCT
admet-184	309	20	diabetes	diabete	VERB
admet-184	309	21	64	64	NUM
admet-184	309	22	(	(	PUNCT
admet-184	309	23	2015	2015	NUM
admet-184	309	24	)	)	PUNCT
admet-184	309	25	766	766	NUM
admet-184	309	26	-	-	SYM
admet-184	309	27	774	774	NUM
admet-184	309	28	.	.	PUNCT
admet-184	310	1	[	[	X
admet-184	310	2	79	79	NUM
admet-184	310	3	]	]	X
admet-184	310	4	e.t	e.t	PROPN
admet-184	310	5	.	.	PROPN
admet-184	310	6	maggio	maggio	PROPN
admet-184	310	7	,	,	PUNCT
admet-184	310	8	us8772231	us8772231	ADJ
admet-184	310	9	b2	b2	NOUN
admet-184	310	10	(	(	PUNCT
admet-184	310	11	2006	2006	NUM
admet-184	310	12	)	)	PUNCT
admet-184	310	13	.	.	PUNCT
admet-184	311	1	[	[	X
admet-184	311	2	80	80	NUM
admet-184	311	3	]	]	X
admet-184	311	4	licensing	licensing	NOUN
admet-184	311	5	agreement	agreement	NOUN
admet-184	311	6	for	for	ADP
admet-184	311	7	nasal	nasal	ADJ
admet-184	311	8	drug	drug	NOUN
admet-184	311	9	delivery	delivery	NOUN
admet-184	311	10	technology	technology	NOUN
admet-184	311	11	platform	platform	NOUN
admet-184	311	12	–	–	PUNCT
admet-184	311	13	nasal	nasal	NOUN
admet-184	311	14	dihydroergotamine	dihydroergotamine	NOUN
admet-184	311	15	for	for	ADP
admet-184	311	16	treatment	treatment	NOUN
admet-184	311	17	of	of	ADP
admet-184	311	18	migraine	migraine	ADJ
admet-184	311	19	headache	headache	NOUN
admet-184	311	20	,	,	PUNCT
admet-184	311	21	http://snbl.com/press-release/licensing-agreement-for-nasaldrug-delivery-technology-platform-nasal-dihydroergotamine-for-treatment-of-migraine-headache/	http://snbl.com/press-release/licensing-agreement-for-nasaldrug-delivery-technology-platform-nasal-dihydroergotamine-for-treatment-of-migraine-headache/	X
admet-184	311	22	(	(	PUNCT
admet-184	311	23	04/16/2015	04/16/2015	NUM
admet-184	311	24	)	)	PUNCT
admet-184	311	25	.	.	PUNCT
admet-184	312	1	[	[	X
admet-184	312	2	81	81	NUM
admet-184	312	3	]	]	X
admet-184	312	4	criticalsorb	criticalsorb	NOUN
admet-184	312	5	is	be	AUX
admet-184	312	6	a	a	DET
admet-184	312	7	proprietary	proprietary	ADJ
admet-184	312	8	absorption	absorption	NOUN
admet-184	312	9	promoter	promoter	NOUN
admet-184	312	10	that	that	PRON
admet-184	312	11	has	have	VERB
admet-184	312	12	the	the	DET
admet-184	312	13	potential	potential	NOUN
admet-184	312	14	to	to	PART
admet-184	312	15	provide	provide	VERB
admet-184	312	16	a	a	DET
admet-184	312	17	viable	viable	ADJ
admet-184	312	18	alternative	alternative	NOUN
admet-184	312	19	to	to	ADP
admet-184	312	20	injection	injection	NOUN
admet-184	312	21	for	for	ADP
admet-184	312	22	a	a	DET
admet-184	312	23	wide	wide	ADJ
admet-184	312	24	variety	variety	NOUN
admet-184	312	25	of	of	ADP
admet-184	312	26	biological	biological	ADJ
admet-184	312	27	and	and	CCONJ
admet-184	312	28	challenging	challenge	VERB
admet-184	312	29	small	small	ADJ
admet-184	312	30	molecule	molecule	NOUN
admet-184	312	31	drugs	drug	NOUN
admet-184	312	32	.	.	PUNCT
admet-184	312	33	,	,	PUNCT
admet-184	312	34	http://www.criticalpharmaceuticals.com/technology/criticalsorb	http://www.criticalpharmaceuticals.com/technology/criticalsorb	PROPN
admet-184	312	35	(	(	PUNCT
admet-184	312	36	04/16/2015	04/16/2015	NUM
admet-184	312	37	)	)	PUNCT
admet-184	312	38	.	.	PUNCT
admet-184	313	1	[	[	X
admet-184	313	2	82	82	X
admet-184	313	3	]	]	X
admet-184	313	4	w.	w.	PROPN
admet-184	313	5	li	li	PROPN
admet-184	313	6	,	,	PUNCT
admet-184	313	7	y.	y.	PROPN
admet-184	313	8	zhou	zhou	PROPN
admet-184	313	9	,	,	PUNCT
admet-184	313	10	n.	n.	PROPN
admet-184	313	11	zhao	zhao	PROPN
admet-184	313	12	,	,	PUNCT
admet-184	313	13	b.	b.	PROPN
admet-184	313	14	hao	hao	PROPN
admet-184	313	15	,	,	PUNCT
admet-184	313	16	x.	x.	PROPN
admet-184	313	17	wang	wang	PROPN
admet-184	313	18	,	,	PUNCT
admet-184	313	19	p.	p.	PROPN
admet-184	313	20	kong	kong	PROPN
admet-184	313	21	,	,	PUNCT
admet-184	313	22	environmental	environmental	ADJ
admet-184	313	23	toxicology	toxicology	NOUN
admet-184	313	24	and	and	CCONJ
admet-184	313	25	pharmacology	pharmacology	NOUN
admet-184	313	26	34	34	NUM
admet-184	313	27	(	(	PUNCT
admet-184	313	28	2012	2012	NUM
admet-184	313	29	)	)	PUNCT
admet-184	313	30	272	272	NUM
admet-184	313	31	-	-	SYM
admet-184	313	32	279	279	NUM
admet-184	313	33	.	.	PUNCT
admet-184	314	1	[	[	X
admet-184	314	2	83	83	NUM
admet-184	314	3	]	]	PUNCT
admet-184	314	4	k.	k.	PROPN
admet-184	314	5	arumugam	arumugam	PROPN
admet-184	314	6	,	,	PUNCT
admet-184	314	7	g.s	g.s	PROPN
admet-184	314	8	.	.	PROPN
admet-184	314	9	subramanian	subramanian	PROPN
admet-184	314	10	,	,	PUNCT
admet-184	314	11	s.r	s.r	PROPN
admet-184	314	12	.	.	PROPN
admet-184	314	13	mallayasamy	mallayasamy	PROPN
admet-184	314	14	,	,	PUNCT
admet-184	314	15	r.k	r.k	PROPN
admet-184	314	16	.	.	PROPN
admet-184	314	17	averineni	averineni	NOUN
admet-184	314	18	,	,	PUNCT
admet-184	314	19	m.s	m.s	PROPN
admet-184	314	20	.	.	PROPN
admet-184	314	21	reddy	reddy	PROPN
admet-184	314	22	,	,	PUNCT
admet-184	314	23	n.	n.	PROPN
admet-184	314	24	udupa	udupa	PROPN
admet-184	314	25	,	,	PUNCT
admet-184	314	26	acta	acta	PROPN
admet-184	314	27	pharmaceutica	pharmaceutica	PROPN
admet-184	314	28	58	58	NUM
admet-184	314	29	(	(	PUNCT
admet-184	314	30	2008	2008	NUM
admet-184	314	31	)	)	PUNCT
admet-184	314	32	287	287	NUM
admet-184	314	33	-	-	SYM
admet-184	314	34	297	297	NUM
admet-184	314	35	.	.	PUNCT
admet-184	315	1	[	[	X
admet-184	315	2	84	84	NUM
admet-184	315	3	]	]	X
admet-184	315	4	m.m	m.m	PROPN
admet-184	315	5	.	.	PROPN
admet-184	315	6	migliore	migliore	PROPN
admet-184	315	7	,	,	PUNCT
admet-184	315	8	t.k	t.k	PROPN
admet-184	315	9	.	.	PROPN
admet-184	315	10	vyas	vyas	PROPN
admet-184	315	11	,	,	PUNCT
admet-184	315	12	r.b	r.b	PROPN
admet-184	315	13	.	.	PROPN
admet-184	315	14	campbell	campbell	PROPN
admet-184	315	15	,	,	PUNCT
admet-184	315	16	m.m	m.m	PROPN
admet-184	315	17	.	.	PROPN
admet-184	315	18	amiji	amiji	PROPN
admet-184	315	19	,	,	PUNCT
admet-184	315	20	b.l	b.l	PROPN
admet-184	315	21	.	.	PROPN
admet-184	315	22	waszczak	waszczak	PROPN
admet-184	315	23	,	,	PUNCT
admet-184	315	24	journal	journal	NOUN
admet-184	315	25	of	of	ADP
admet-184	315	26	pharmaceutical	pharmaceutical	PROPN
admet-184	315	27	sciences	science	NOUN
admet-184	315	28	99	99	NUM
admet-184	315	29	(	(	PUNCT
admet-184	315	30	2010	2010	NUM
admet-184	315	31	)	)	PUNCT
admet-184	315	32	1745	1745	NUM
admet-184	315	33	-	-	SYM
admet-184	315	34	1761	1761	NUM
admet-184	315	35	.	.	PUNCT
admet-184	316	1	[	[	X
admet-184	316	2	85	85	NUM
admet-184	316	3	]	]	X
admet-184	316	4	c.	c.	PROPN
admet-184	316	5	zheng	zheng	PROPN
admet-184	316	6	,	,	PUNCT
admet-184	316	7	q.	q.	PROPN
admet-184	316	8	guo	guo	PROPN
admet-184	316	9	,	,	PUNCT
admet-184	316	10	z.	z.	PROPN
admet-184	316	11	wu	wu	PROPN
admet-184	316	12	,	,	PUNCT
admet-184	316	13	l.	l.	PROPN
admet-184	316	14	sun	sun	PROPN
admet-184	316	15	,	,	PUNCT
admet-184	316	16	z.	z.	PROPN
admet-184	316	17	zhang	zhang	PROPN
admet-184	316	18	,	,	PUNCT
admet-184	316	19	c.	c.	PROPN
admet-184	316	20	li	li	PROPN
admet-184	316	21	,	,	PUNCT
admet-184	316	22	x.	x.	PROPN
admet-184	316	23	zhang	zhang	PROPN
admet-184	316	24	,	,	PUNCT
admet-184	316	25	european	european	PROPN
admet-184	316	26	journal	journal	PROPN
admet-184	316	27	of	of	ADP
admet-184	316	28	pharmaceutical	pharmaceutical	PROPN
admet-184	316	29	sciences	science	NOUN
admet-184	316	30	49	49	NUM
admet-184	316	31	(	(	PUNCT
admet-184	316	32	2013	2013	NUM
admet-184	316	33	)	)	PUNCT
admet-184	316	34	474	474	NUM
admet-184	316	35	-	-	SYM
admet-184	316	36	482	482	NUM
admet-184	316	37	.	.	PUNCT
admet-184	317	1	[	[	X
admet-184	317	2	86	86	NUM
admet-184	317	3	]	]	X
admet-184	317	4	r.	r.	PROPN
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admet-184	317	6	,	,	PUNCT
admet-184	317	7	s.	s.	PROPN
admet-184	317	8	mutalik	mutalik	PROPN
admet-184	317	9	,	,	PUNCT
admet-184	317	10	m.	m.	NOUN
admet-184	317	11	venkatesh	venkatesh	PROPN
admet-184	317	12	,	,	PUNCT
admet-184	317	13	s.	s.	PROPN
admet-184	317	14	vidyasagar	vidyasagar	PROPN
admet-184	317	15	,	,	PUNCT
admet-184	317	16	n.	n.	PROPN
admet-184	317	17	udupa	udupa	ADJ
admet-184	317	18	,	,	PUNCT
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admet-184	317	20	pharmscitech	pharmscitech	VERB
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admet-184	317	22	(	(	PUNCT
admet-184	317	23	2005	2005	NUM
admet-184	317	24	)	)	PUNCT
admet-184	317	25	e184e189	e184e189	PUNCT
admet-184	317	26	.	.	PUNCT
admet-184	318	1	[	[	X
admet-184	318	2	87	87	NUM
admet-184	318	3	]	]	X
admet-184	318	4	a.k	a.k	PROPN
admet-184	318	5	.	.	PROPN
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admet-184	318	7	,	,	PUNCT
admet-184	318	8	p.n	p.n	PROPN
admet-184	318	9	.	.	PROPN
admet-184	318	10	gupta	gupta	PROPN
admet-184	318	11	,	,	PUNCT
admet-184	318	12	a.	a.	NOUN
admet-184	318	13	khanna	khanna	PROPN
admet-184	318	14	,	,	PUNCT
admet-184	318	15	r.k	r.k	PROPN
admet-184	318	16	.	.	PROPN
admet-184	318	17	sharma	sharma	PROPN
admet-184	318	18	,	,	PUNCT
admet-184	318	19	h.k	h.k	PROPN
admet-184	318	20	.	.	PROPN
admet-184	318	21	chandrawanshi	chandrawanshi	PROPN
admet-184	318	22	,	,	PUNCT
admet-184	318	23	n.	n.	PROPN
admet-184	318	24	gupta	gupta	PROPN
admet-184	318	25	,	,	PUNCT
admet-184	318	26	u.k	u.k	PROPN
admet-184	318	27	.	.	PROPN
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admet-184	318	29	,	,	PUNCT
admet-184	318	30	s.k	s.k	PROPN
admet-184	318	31	.	.	PROPN
admet-184	318	32	yadav	yadav	PROPN
admet-184	318	33	,	,	PUNCT
admet-184	318	34	die	die	VERB
admet-184	318	35	pharmazie	pharmazie	PROPN
admet-184	318	36	65	65	NUM
admet-184	318	37	(	(	PUNCT
admet-184	318	38	2010	2010	NUM
admet-184	318	39	)	)	PUNCT
admet-184	318	40	188	188	NUM
admet-184	318	41	-	-	SYM
admet-184	318	42	193	193	NUM
admet-184	318	43	.	.	PUNCT
admet-184	319	1	[	[	X
admet-184	319	2	88	88	NUM
admet-184	319	3	]	]	X
admet-184	319	4	r.	r.	PROPN
admet-184	319	5	stote	stote	PROPN
admet-184	319	6	,	,	PUNCT
admet-184	319	7	m.	m.	NOUN
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admet-184	319	9	,	,	PUNCT
admet-184	319	10	t.	t.	PROPN
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admet-184	319	12	,	,	PUNCT
admet-184	319	13	l.	l.	PROPN
admet-184	319	14	shi	shi	PROPN
admet-184	319	15	,	,	PUNCT
admet-184	319	16	p.	p.	PROPN
admet-184	319	17	strange	strange	ADJ
admet-184	319	18	,	,	PUNCT
admet-184	319	19	journal	journal	NOUN
admet-184	319	20	of	of	ADP
admet-184	319	21	diabetes	diabetes	NOUN
admet-184	319	22	science	science	NOUN
admet-184	319	23	and	and	CCONJ
admet-184	319	24	technology	technology	NOUN
admet-184	319	25	5	5	NUM
admet-184	319	26	(	(	PUNCT
admet-184	319	27	2011	2011	NUM
admet-184	319	28	)	)	PUNCT
admet-184	319	29	113	113	NUM
admet-184	319	30	-	-	SYM
admet-184	319	31	119	119	NUM
admet-184	319	32	.	.	PUNCT
admet-184	320	1	[	[	X
admet-184	320	2	89	89	NUM
admet-184	320	3	]	]	PUNCT
admet-184	320	4	l.	l.	PROPN
admet-184	320	5	kozlovskaya	kozlovskaya	PROPN
admet-184	320	6	,	,	PUNCT
admet-184	320	7	m.	m.	PROPN
admet-184	320	8	abou	abou	PROPN
admet-184	320	9	-	-	PUNCT
admet-184	320	10	kaoud	kaoud	PROPN
admet-184	320	11	,	,	PUNCT
admet-184	320	12	d.	d.	PROPN
admet-184	320	13	stepensky	stepensky	PROPN
admet-184	320	14	,	,	PUNCT
admet-184	320	15	journal	journal	NOUN
admet-184	320	16	of	of	ADP
admet-184	320	17	controlled	control	VERB
admet-184	320	18	release	release	NOUN
admet-184	320	19	189	189	NUM
admet-184	320	20	(	(	PUNCT
admet-184	320	21	2014	2014	NUM
admet-184	320	22	)	)	PUNCT
admet-184	320	23	133	133	NUM
admet-184	320	24	-	-	SYM
admet-184	320	25	140	140	NUM
admet-184	320	26	.	.	PUNCT
admet-184	321	1	©	©	PROPN
admet-184	321	2	2015	2015	NUM
admet-184	321	3	by	by	ADP
admet-184	321	4	the	the	DET
admet-184	321	5	authors	author	NOUN
admet-184	321	6	;	;	PUNCT
admet-184	321	7	licensee	licensee	PROPN
admet-184	321	8	iapc	iapc	PROPN
admet-184	321	9	,	,	PUNCT
admet-184	321	10	zagreb	zagreb	PROPN
admet-184	321	11	,	,	PUNCT
admet-184	321	12	croatia	croatia	PROPN
admet-184	321	13	.	.	PUNCT
admet-184	322	1	this	this	DET
admet-184	322	2	article	article	NOUN
admet-184	322	3	is	be	AUX
admet-184	322	4	an	an	DET
admet-184	322	5	open	open	ADJ
admet-184	322	6	-	-	PUNCT
admet-184	322	7	access	access	NOUN
admet-184	322	8	article	article	NOUN
admet-184	322	9	distributed	distribute	VERB
admet-184	322	10	under	under	ADP
admet-184	322	11	the	the	DET
admet-184	322	12	terms	term	NOUN
admet-184	322	13	and	and	CCONJ
admet-184	322	14	conditions	condition	NOUN
admet-184	322	15	of	of	ADP
admet-184	322	16	the	the	DET
admet-184	322	17	creative	creative	ADJ
admet-184	322	18	commons	common	NOUN
admet-184	322	19	attribution	attribution	NOUN
admet-184	322	20	license	license	NOUN
admet-184	322	21	(	(	PUNCT
admet-184	322	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN
admet-184	322	23	)	)	PUNCT
admet-184	322	24	http://www.bloomberg.com/apps/news?pid=newsarchive&sid=af8dtg4w0xt4	http://www.bloomberg.com/apps/news?pid=newsarchive&sid=af8dtg4w0xt4	NOUN
admet-184	323	1	http://snbl.com/press-release/licensing-agreement-for-nasal-drug-delivery-technology-platform-nasal-dihydroergotamine-for-treatment-of-migraine-headache/	http://snbl.com/press-release/licensing-agreement-for-nasal-drug-delivery-technology-platform-nasal-dihydroergotamine-for-treatment-of-migraine-headache/	NOUN
admet-184	323	2	http://snbl.com/press-release/licensing-agreement-for-nasal-drug-delivery-technology-platform-nasal-dihydroergotamine-for-treatment-of-migraine-headache/	http://snbl.com/press-release/licensing-agreement-for-nasal-drug-delivery-technology-platform-nasal-dihydroergotamine-for-treatment-of-migraine-headache/	NUM
admet-184	323	3	http://www.criticalpharmaceuticals.com/technology/criticalsorb	http://www.criticalpharmaceuticals.com/technology/criticalsorb	VERB
admet-184	323	4	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN