id	sid	tid	token	lemma	pos
admet-1845	1	1	preparation	preparation	NOUN
admet-1845	1	2	of	of	ADP
admet-1845	1	3	self	self	NOUN
admet-1845	1	4	-	-	PUNCT
admet-1845	1	5	assembly	assembly	NOUN
admet-1845	1	6	silica	silica	NOUN
admet-1845	1	7	redox	redox	NOUN
admet-1845	1	8	nanoparticles	nanoparticle	NOUN
admet-1845	1	9	to	to	PART
admet-1845	1	10	improve	improve	VERB
admet-1845	1	11	drug	drug	NOUN
admet-1845	1	12	encapsulation	encapsulation	NOUN
admet-1845	1	13	and	and	CCONJ
admet-1845	1	14	suppress	suppress	VERB
admet-1845	1	15	the	the	DET
admet-1845	1	16	adverse	adverse	ADJ
admet-1845	1	17	effect	effect	NOUN
admet-1845	1	18	of	of	ADP
admet-1845	1	19	doxorubicin	doxorubicin	PROPN
admet-1845	1	20	doi	doi	PROPN
admet-1845	1	21	:	:	PUNCT
admet-1845	1	22	https://doi.org/10.5599/adme	https://doi.org/10.5599/adme	NOUN
admet-1845	1	23	t.1845	t.1845	NOUN
admet-1845	1	24	551	551	NUM
admet-1845	1	25	admet	admet	X
admet-1845	1	26	&	&	CCONJ
admet-1845	1	27	dmpk	dmpk	PROPN
admet-1845	1	28	11(4	11(4	NUM
admet-1845	1	29	)	)	PUNCT
admet-1845	1	30	(	(	PUNCT
admet-1845	1	31	2023	2023	NUM
admet-1845	1	32	)	)	PUNCT
admet-1845	1	33	551	551	NUM
admet-1845	1	34	-	-	SYM
admet-1845	1	35	560	560	NUM
admet-1845	1	36	;	;	PUNCT
admet-1845	1	37	doi	doi	NOUN
admet-1845	1	38	:	:	PUNCT
admet-1845	1	39	https://doi.org/10.5599/admet.1845	https://doi.org/10.5599/admet.1845	NOUN
admet-1845	1	40	open	open	ADJ
admet-1845	1	41	access	access	NOUN
admet-1845	1	42	:	:	PUNCT
admet-1845	1	43	issn	issn	PROPN
admet-1845	1	44	:	:	PUNCT
admet-1845	1	45	1848	1848	NUM
admet-1845	1	46	-	-	SYM
admet-1845	1	47	7718	7718	NUM
admet-1845	1	48	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1845	1	49	original	original	ADJ
admet-1845	1	50	scientific	scientific	ADJ
admet-1845	1	51	paper	paper	NOUN
admet-1845	1	52	preparation	preparation	NOUN
admet-1845	1	53	of	of	ADP
admet-1845	1	54	self	self	NOUN
admet-1845	1	55	-	-	PUNCT
admet-1845	1	56	assembly	assembly	NOUN
admet-1845	1	57	silica	silica	NOUN
admet-1845	1	58	redox	redox	NOUN
admet-1845	1	59	nanoparticles	nanoparticle	NOUN
admet-1845	1	60	to	to	PART
admet-1845	1	61	improve	improve	VERB
admet-1845	1	62	drug	drug	NOUN
admet-1845	1	63	encapsulation	encapsulation	NOUN
admet-1845	1	64	and	and	CCONJ
admet-1845	1	65	suppress	suppress	VERB
admet-1845	1	66	the	the	DET
admet-1845	1	67	adverse	adverse	ADJ
admet-1845	1	68	effect	effect	NOUN
admet-1845	1	69	of	of	ADP
admet-1845	1	70	doxorubicin	doxorubicin	PROPN
admet-1845	1	71	minh	minh	PROPN
admet-1845	1	72	-	-	PUNCT
admet-1845	1	73	dat	dat	PROPN
admet-1845	1	74	quoc	quoc	NOUN
admet-1845	1	75	tang1,2	tang1,2	PROPN
admet-1845	1	76	,	,	PUNCT
admet-1845	1	77	#	#	PRON
admet-1845	1	78	,	,	PUNCT
admet-1845	1	79	nhu	nhu	PROPN
admet-1845	1	80	-	-	PROPN
admet-1845	1	81	thuy	thuy	PROPN
admet-1845	1	82	trinh1,2	trinh1,2	PROPN
admet-1845	1	83	,	,	PUNCT
admet-1845	1	84	#	#	X
admet-1845	1	85	,	,	PUNCT
admet-1845	1	86	dung	dung	NOUN
admet-1845	1	87	vu1,2	vu1,2	NOUN
admet-1845	1	88	,	,	PUNCT
admet-1845	1	89	thu	thu	PROPN
admet-1845	1	90	-	-	PUNCT
admet-1845	1	91	ha	ha	INTJ
admet-1845	1	92	thi	thi	PROPN
admet-1845	1	93	nguyen1,2	nguyen1,2	PROPN
admet-1845	1	94	,	,	PUNCT
admet-1845	1	95	hung	hung	PROPN
admet-1845	1	96	thanh	thanh	PROPN
admet-1845	1	97	dong1,2	dong1,2	PROPN
admet-1845	1	98	,	,	PUNCT
admet-1845	1	99	toi	toi	PROPN
admet-1845	1	100	van	van	PROPN
admet-1845	1	101	vo1,2	vo1,2	PROPN
admet-1845	1	102	and	and	CCONJ
admet-1845	1	103	long	long	ADJ
admet-1845	1	104	binh	binh	PROPN
admet-1845	1	105	vong1,2	vong1,2	PROPN
admet-1845	1	106	,	,	PUNCT
admet-1845	1	107	*	*	PROPN
admet-1845	2	1	1school	1school	NUM
admet-1845	2	2	of	of	ADP
admet-1845	2	3	biomedical	biomedical	ADJ
admet-1845	2	4	engineering	engineering	NOUN
admet-1845	2	5	,	,	PUNCT
admet-1845	2	6	international	international	ADJ
admet-1845	2	7	university	university	NOUN
admet-1845	2	8	,	,	PUNCT
admet-1845	2	9	ho	ho	PROPN
admet-1845	2	10	chi	chi	PROPN
admet-1845	2	11	minh	minh	PROPN
admet-1845	2	12	700000	700000	NUM
admet-1845	2	13	,	,	PUNCT
admet-1845	2	14	vietnam	vietnam	PROPN
admet-1845	2	15	2vietnam	2vietnam	NUM
admet-1845	2	16	national	national	PROPN
admet-1845	2	17	university	university	NOUN
admet-1845	2	18	ho	ho	PROPN
admet-1845	2	19	chi	chi	PROPN
admet-1845	2	20	minh	minh	PROPN
admet-1845	2	21	city	city	NOUN
admet-1845	2	22	(	(	PUNCT
admet-1845	2	23	vnu	vnu	PROPN
admet-1845	2	24	-	-	PUNCT
admet-1845	2	25	hcm	hcm	PROPN
admet-1845	2	26	)	)	PUNCT
admet-1845	2	27	,	,	PUNCT
admet-1845	2	28	ho	ho	PROPN
admet-1845	2	29	chi	chi	PROPN
admet-1845	2	30	minh	minh	PROPN
admet-1845	2	31	700000	700000	NUM
admet-1845	2	32	,	,	PUNCT
admet-1845	2	33	vietnam	vietnam	PROPN
admet-1845	2	34	#	#	SYM
admet-1845	2	35	equal	equal	ADJ
admet-1845	2	36	contribution	contribution	NOUN
admet-1845	2	37	*	*	PUNCT
admet-1845	2	38	corresponding	correspond	VERB
admet-1845	2	39	author	author	NOUN
admet-1845	2	40	:	:	PUNCT
admet-1845	2	41	e	e	NOUN
admet-1845	2	42	-	-	NOUN
admet-1845	2	43	mail	mail	NOUN
admet-1845	2	44	:	:	PUNCT
admet-1845	2	45	vblong@hcmiu.edu.vn	vblong@hcmiu.edu.vn	NOUN
admet-1845	2	46	;	;	PUNCT
admet-1845	2	47	tel	tel	PROPN
admet-1845	2	48	.	.	PROPN
admet-1845	2	49	:	:	PUNCT
admet-1845	3	1	+81	+81	PROPN
admet-1845	3	2	29	29	NUM
admet-1845	3	3	-	-	SYM
admet-1845	3	4	853	853	NUM
admet-1845	3	5	-	-	PUNCT
admet-1845	3	6	5749	5749	NUM
admet-1845	3	7	fax	fax	NOUN
admet-1845	3	8	:	:	PUNCT
admet-1845	3	9	+81	+81	ADJ
admet-1845	3	10	29	29	NUM
admet-1845	3	11	-	-	SYM
admet-1845	3	12	853	853	NUM
admet-1845	3	13	-	-	SYM
admet-1845	3	14	5749	5749	NUM
admet-1845	3	15	received	receive	VERB
admet-1845	3	16	:	:	PUNCT
admet-1845	3	17	april	april	PROPN
admet-1845	3	18	27	27	NUM
admet-1845	3	19	,	,	PUNCT
admet-1845	3	20	2023	2023	NUM
admet-1845	3	21	;	;	PUNCT
admet-1845	3	22	revised	revise	VERB
admet-1845	3	23	:	:	PUNCT
admet-1845	3	24	june	june	PROPN
admet-1845	3	25	29	29	NUM
admet-1845	3	26	,	,	PUNCT
admet-1845	3	27	2023	2023	NUM
admet-1845	3	28	;	;	PUNCT
admet-1845	3	29	published	publish	VERB
admet-1845	3	30	:	:	PUNCT
admet-1845	3	31	july	july	PROPN
admet-1845	3	32	4,2023	4,2023	PROPN
admet-1845	3	33	abstract	abstract	ADJ
admet-1845	3	34	background	background	NOUN
admet-1845	3	35	and	and	CCONJ
admet-1845	3	36	purpose	purpose	NOUN
admet-1845	3	37	:	:	PUNCT
admet-1845	3	38	the	the	DET
admet-1845	3	39	utilization	utilization	NOUN
admet-1845	3	40	of	of	ADP
admet-1845	3	41	doxorubicin	doxorubicin	PROPN
admet-1845	3	42	(	(	PUNCT
admet-1845	3	43	dox	dox	NOUN
admet-1845	3	44	)	)	PUNCT
admet-1845	3	45	in	in	ADP
admet-1845	3	46	clinal	clinal	ADJ
admet-1845	3	47	trials	trial	NOUN
admet-1845	3	48	is	be	AUX
admet-1845	3	49	also	also	ADV
admet-1845	3	50	challenging	challenge	VERB
admet-1845	3	51	owing	owe	VERB
admet-1845	3	52	to	to	ADP
admet-1845	3	53	its	its	PRON
admet-1845	3	54	adverse	adverse	ADJ
admet-1845	3	55	effects	effect	NOUN
admet-1845	3	56	,	,	PUNCT
admet-1845	3	57	including	include	VERB
admet-1845	3	58	low	low	ADJ
admet-1845	3	59	oral	oral	ADJ
admet-1845	3	60	bioavailability	bioavailability	NOUN
admet-1845	3	61	,	,	PUNCT
admet-1845	3	62	generation	generation	NOUN
admet-1845	3	63	of	of	ADP
admet-1845	3	64	reactive	reactive	ADJ
admet-1845	3	65	oxygen	oxygen	NOUN
admet-1845	3	66	species	specie	NOUN
admet-1845	3	67	(	(	PUNCT
admet-1845	3	68	ros	ros	PROPN
admet-1845	3	69	)	)	PUNCT
admet-1845	3	70	,	,	PUNCT
admet-1845	3	71	cardiotoxicity	cardiotoxicity	NOUN
admet-1845	3	72	,	,	PUNCT
admet-1845	3	73	and	and	CCONJ
admet-1845	3	74	epithelial	epithelial	ADJ
admet-1845	3	75	barrier	barrier	NOUN
admet-1845	3	76	damage	damage	NOUN
admet-1845	3	77	.	.	PUNCT
admet-1845	4	1	recently	recently	ADV
admet-1845	4	2	,	,	PUNCT
admet-1845	4	3	scavenging	scavenge	VERB
admet-1845	4	4	of	of	ADP
admet-1845	4	5	ros	ros	PROPN
admet-1845	4	6	reduced	reduce	VERB
admet-1845	4	7	the	the	DET
admet-1845	4	8	cytotoxicity	cytotoxicity	NOUN
admet-1845	4	9	of	of	ADP
admet-1845	4	10	dox	dox	NOUN
admet-1845	4	11	,	,	PUNCT
admet-1845	4	12	suggesting	suggest	VERB
admet-1845	4	13	a	a	DET
admet-1845	4	14	new	new	ADJ
admet-1845	4	15	approach	approach	NOUN
admet-1845	4	16	for	for	ADP
admet-1845	4	17	using	use	VERB
admet-1845	4	18	dox	dox	NOUN
admet-1845	4	19	as	as	ADP
admet-1845	4	20	an	an	DET
admet-1845	4	21	anticancer	anticancer	NOUN
admet-1845	4	22	treatment	treatment	NOUN
admet-1845	4	23	.	.	PUNCT
admet-1845	5	1	thus	thus	ADV
admet-1845	5	2	,	,	PUNCT
admet-1845	5	3	in	in	ADP
admet-1845	5	4	this	this	DET
admet-1845	5	5	study	study	NOUN
admet-1845	5	6	,	,	PUNCT
admet-1845	5	7	non	non	ADJ
admet-1845	5	8	-	-	NOUN
admet-1845	5	9	silica	silica	NOUN
admet-1845	5	10	and	and	CCONJ
admet-1845	5	11	silica	silica	VERB
admet-1845	5	12	redox	redox	ADJ
admet-1845	5	13	nanoparticles	nanoparticle	NOUN
admet-1845	5	14	(	(	PUNCT
admet-1845	5	15	denoted	denote	VERB
admet-1845	5	16	as	as	ADP
admet-1845	5	17	rnpn	rnpn	NOUN
admet-1845	5	18	and	and	CCONJ
admet-1845	5	19	sirnp	sirnp	PROPN
admet-1845	5	20	,	,	PUNCT
admet-1845	5	21	respectively	respectively	ADV
admet-1845	5	22	)	)	PUNCT
admet-1845	5	23	with	with	ADP
admet-1845	5	24	ros	ros	PROPN
admet-1845	5	25	scavenging	scavenging	NOUN
admet-1845	5	26	features	feature	NOUN
admet-1845	5	27	have	have	AUX
admet-1845	5	28	been	be	AUX
admet-1845	5	29	designed	design	VERB
admet-1845	5	30	to	to	PART
admet-1845	5	31	encapsulate	encapsulate	VERB
admet-1845	5	32	dox	dox	NOUN
admet-1845	5	33	and	and	CCONJ
admet-1845	5	34	reduce	reduce	VERB
admet-1845	5	35	its	its	PRON
admet-1845	5	36	cytotoxicity	cytotoxicity	NOUN
admet-1845	5	37	.	.	PUNCT
admet-1845	6	1	experimental	experimental	ADJ
admet-1845	6	2	approach	approach	NOUN
admet-1845	6	3	:	:	PUNCT
admet-1845	6	4	dox	dox	NOUN
admet-1845	6	5	-	-	PUNCT
admet-1845	6	6	loaded	load	VERB
admet-1845	6	7	rnpn	rnpn	NOUN
admet-1845	6	8	(	(	PUNCT
admet-1845	6	9	dox@rnpn	dox@rnpn	PROPN
admet-1845	6	10	)	)	PUNCT
admet-1845	6	11	and	and	CCONJ
admet-1845	6	12	dox	dox	NOUN
admet-1845	6	13	-	-	PUNCT
admet-1845	6	14	loaded	load	VERB
admet-1845	6	15	sirnp	sirnp	NOUN
admet-1845	6	16	(	(	PUNCT
admet-1845	6	17	dox@sirnp	dox@sirnp	PROPN
admet-1845	6	18	)	)	PUNCT
admet-1845	6	19	were	be	AUX
admet-1845	6	20	prepared	prepare	VERB
admet-1845	6	21	by	by	ADP
admet-1845	6	22	co	co	VERB
admet-1845	6	23	-	-	ADJ
admet-1845	6	24	dissolving	dissolve	VERB
admet-1845	6	25	dox	dox	NOUN
admet-1845	6	26	with	with	ADP
admet-1845	6	27	rnpn	rnpn	PROPN
admet-1845	6	28	and	and	CCONJ
admet-1845	6	29	sirnp	sirnp	PROPN
admet-1845	6	30	,	,	PUNCT
admet-1845	6	31	respectively	respectively	ADV
admet-1845	6	32	.	.	PUNCT
admet-1845	7	1	the	the	DET
admet-1845	7	2	size	size	NOUN
admet-1845	7	3	and	and	CCONJ
admet-1845	7	4	stability	stability	NOUN
admet-1845	7	5	of	of	ADP
admet-1845	7	6	nanoparticles	nanoparticle	NOUN
admet-1845	7	7	were	be	AUX
admet-1845	7	8	characterized	characterize	VERB
admet-1845	7	9	by	by	ADP
admet-1845	7	10	the	the	DET
admet-1845	7	11	dynamic	dynamic	ADJ
admet-1845	7	12	light	light	ADJ
admet-1845	7	13	scattering	scatter	VERB
admet-1845	7	14	system	system	NOUN
admet-1845	7	15	.	.	PUNCT
admet-1845	8	1	additionally	additionally	ADV
admet-1845	8	2	,	,	PUNCT
admet-1845	8	3	encapsulation	encapsulation	NOUN
admet-1845	8	4	efficiency	efficiency	NOUN
admet-1845	8	5	,	,	PUNCT
admet-1845	8	6	loading	loading	NOUN
admet-1845	8	7	capacity	capacity	NOUN
admet-1845	8	8	,	,	PUNCT
admet-1845	8	9	and	and	CCONJ
admet-1845	8	10	release	release	VERB
admet-1845	8	11	profile	profile	NOUN
admet-1845	8	12	of	of	ADP
admet-1845	8	13	dox@rnp	dox@rnp	PROPN
admet-1845	8	14	n	n	PROPN
admet-1845	8	15	and	and	CCONJ
admet-1845	8	16	dox@sirnp	dox@sirnp	PROPN
admet-1845	8	17	were	be	AUX
admet-1845	8	18	identified	identify	VERB
admet-1845	8	19	by	by	ADP
admet-1845	8	20	measuring	measure	VERB
admet-1845	8	21	the	the	DET
admet-1845	8	22	absorbance	absorbance	NOUN
admet-1845	8	23	of	of	ADP
admet-1845	8	24	dox	dox	NOUN
admet-1845	8	25	.	.	PUNCT
admet-1845	9	1	finally	finally	ADV
admet-1845	9	2	,	,	PUNCT
admet-1845	9	3	the	the	DET
admet-1845	9	4	cytotoxicity	cytotoxicity	NOUN
admet-1845	9	5	of	of	ADP
admet-1845	9	6	dox@rnp	dox@rnp	PROPN
admet-1845	9	7	n	n	PROPN
admet-1845	9	8	and	and	CCONJ
admet-1845	9	9	dox@sirnp	dox@sirnp	PROPN
admet-1845	9	10	against	against	ADP
admet-1845	9	11	normal	normal	ADJ
admet-1845	9	12	murine	murine	ADJ
admet-1845	9	13	fibroblast	fibroblast	ADJ
admet-1845	9	14	cells	cell	NOUN
admet-1845	9	15	(	(	PUNCT
admet-1845	9	16	l929	l929	PROPN
admet-1845	9	17	)	)	PUNCT
admet-1845	9	18	,	,	PUNCT
admet-1845	9	19	human	human	ADJ
admet-1845	9	20	hepatocellular	hepatocellular	ADJ
admet-1845	9	21	carcinoma	carcinoma	NOUN
admet-1845	9	22	cells	cell	NOUN
admet-1845	9	23	(	(	PUNCT
admet-1845	9	24	hepg2	hepg2	NOUN
admet-1845	9	25	)	)	PUNCT
admet-1845	9	26	,	,	PUNCT
admet-1845	9	27	and	and	CCONJ
admet-1845	9	28	human	human	ADJ
admet-1845	9	29	breast	breast	NOUN
admet-1845	9	30	cancer	cancer	NOUN
admet-1845	9	31	cells	cell	NOUN
admet-1845	9	32	(	(	PUNCT
admet-1845	9	33	mcf-7	mcf-7	NOUN
admet-1845	9	34	)	)	PUNCT
admet-1845	9	35	were	be	AUX
admet-1845	9	36	also	also	ADV
admet-1845	9	37	investigated	investigate	VERB
admet-1845	9	38	.	.	PUNCT
admet-1845	10	1	key	key	ADJ
admet-1845	10	2	results	result	NOUN
admet-1845	10	3	:	:	PUNCT
admet-1845	10	4	the	the	DET
admet-1845	10	5	obtained	obtain	VERB
admet-1845	10	6	result	result	NOUN
admet-1845	10	7	showed	show	VERB
admet-1845	10	8	that	that	SCONJ
admet-1845	10	9	rnpn	rnpn	NOUN
admet-1845	10	10	exhibited	exhibit	VERB
admet-1845	10	11	a	a	DET
admet-1845	10	12	ph	ph	ADJ
admet-1845	10	13	-	-	ADJ
admet-1845	10	14	sensitive	sensitive	ADJ
admet-1845	10	15	character	character	NOUN
admet-1845	10	16	while	while	SCONJ
admet-1845	10	17	silanol	silanol	ADJ
admet-1845	10	18	moieties	moiety	NOUN
admet-1845	10	19	improved	improve	VERB
admet-1845	10	20	the	the	DET
admet-1845	10	21	stability	stability	NOUN
admet-1845	10	22	of	of	ADP
admet-1845	10	23	sirnp	sirnp	PROPN
admet-1845	10	24	in	in	ADP
admet-1845	10	25	physiological	physiological	ADJ
admet-1845	10	26	conditions	condition	NOUN
admet-1845	10	27	.	.	PUNCT
admet-1845	11	1	dox@rnpn	dox@rnpn	NOUN
admet-1845	11	2	and	and	CCONJ
admet-1845	11	3	dox@sirnp	dox@sirnp	PROPN
admet-1845	11	4	were	be	AUX
admet-1845	11	5	formed	form	VERB
admet-1845	11	6	at	at	ADP
admet-1845	11	7	several	several	ADJ
admet-1845	11	8	tens	ten	NOUN
admet-1845	11	9	of	of	ADP
admet-1845	11	10	nanometers	nanometer	NOUN
admet-1845	11	11	in	in	ADP
admet-1845	11	12	diameter	diameter	NOUN
admet-1845	11	13	with	with	ADP
admet-1845	11	14	narrow	narrow	ADJ
admet-1845	11	15	distribution	distribution	NOUN
admet-1845	11	16	.	.	PUNCT
admet-1845	12	1	moreover	moreover	ADV
admet-1845	12	2	,	,	PUNCT
admet-1845	12	3	dox@sirnp	dox@sirnp	PROPN
admet-1845	12	4	stabilized	stabilize	VERB
admet-1845	12	5	under	under	ADP
admet-1845	12	6	different	different	ADJ
admet-1845	12	7	ph	ph	ADJ
admet-1845	12	8	buffers	buffer	NOUN
admet-1845	12	9	,	,	PUNCT
admet-1845	12	10	especially	especially	ADV
admet-1845	12	11	gastric	gastric	ADJ
admet-1845	12	12	ph	ph	VERB
admet-1845	12	13	,	,	PUNCT
admet-1845	12	14	and	and	CCONJ
admet-1845	12	15	improved	improve	VERB
admet-1845	12	16	encapsulation	encapsulation	NOUN
admet-1845	12	17	of	of	ADP
admet-1845	12	18	dox	dox	NOUN
admet-1845	12	19	owing	owe	VERB
admet-1845	12	20	to	to	ADP
admet-1845	12	21	the	the	DET
admet-1845	12	22	addition	addition	NOUN
admet-1845	12	23	of	of	ADP
admet-1845	12	24	silanol	silanol	NOUN
admet-1845	12	25	groups	group	NOUN
admet-1845	12	26	.	.	PUNCT
admet-1845	13	1	dox@rnp	dox@rnp	NOUN
admet-1845	13	2	n	n	ADV
admet-1845	13	3	and	and	CCONJ
admet-1845	13	4	dox@sirnp	dox@sirnp	PROPN
admet-1845	13	5	maintained	maintain	VERB
admet-1845	13	6	anticancer	anticancer	NOUN
admet-1845	13	7	activity	activity	NOUN
admet-1845	13	8	of	of	ADP
admet-1845	13	9	dox	dox	NOUN
admet-1845	13	10	against	against	ADP
admet-1845	13	11	hepg2	hepg2	PROPN
admet-1845	13	12	,	,	PUNCT
admet-1845	13	13	and	and	CCONJ
admet-1845	13	14	mcf-7	mcf-7	NOUN
admet-1845	13	15	cells	cell	NOUN
admet-1845	13	16	,	,	PUNCT
admet-1845	13	17	while	while	SCONJ
admet-1845	13	18	their	their	PRON
admet-1845	13	19	cytotoxicity	cytotoxicity	NOUN
admet-1845	13	20	on	on	ADP
admet-1845	13	21	l929	l929	PROPN
admet-1845	13	22	cells	cell	NOUN
admet-1845	13	23	was	be	AUX
admet-1845	13	24	significantly	significantly	ADV
admet-1845	13	25	reduced	reduce	VERB
admet-1845	13	26	compared	compare	VERB
admet-1845	13	27	to	to	ADP
admet-1845	13	28	free	free	ADJ
admet-1845	13	29	dox	dox	NOUN
admet-1845	13	30	treatment	treatment	NOUN
admet-1845	13	31	.	.	PUNCT
admet-1845	14	1	conclusion	conclusion	NOUN
admet-1845	14	2	:	:	PUNCT
admet-1845	14	3	dox@rnpn	dox@rnpn	NOUN
admet-1845	14	4	and	and	CCONJ
admet-1845	14	5	dox@sirnp	dox@sirnp	PROPN
admet-1845	14	6	could	could	AUX
admet-1845	14	7	effectively	effectively	ADV
admet-1845	14	8	suppress	suppress	VERB
admet-1845	14	9	the	the	DET
admet-1845	14	10	adverse	adverse	ADJ
admet-1845	14	11	effect	effect	NOUN
admet-1845	14	12	of	of	ADP
admet-1845	14	13	dox	dox	NOUN
admet-1845	14	14	,	,	PUNCT
admet-1845	14	15	suggesting	suggest	VERB
admet-1845	14	16	the	the	DET
admet-1845	14	17	potential	potential	NOUN
admet-1845	14	18	to	to	PART
admet-1845	14	19	become	become	VERB
admet-1845	14	20	promising	promising	ADJ
admet-1845	14	21	nanomedicines	nanomedicine	NOUN
admet-1845	14	22	for	for	ADP
admet-1845	14	23	cancer	cancer	NOUN
admet-1845	14	24	treatments	treatment	NOUN
admet-1845	14	25	.	.	PUNCT
admet-1845	15	1	©	©	ADP
admet-1845	15	2	2023	2023	NUM
admet-1845	15	3	by	by	ADP
admet-1845	15	4	the	the	DET
admet-1845	15	5	authors	author	NOUN
admet-1845	15	6	.	.	PUNCT
admet-1845	16	1	this	this	DET
admet-1845	16	2	article	article	NOUN
admet-1845	16	3	is	be	AUX
admet-1845	16	4	an	an	DET
admet-1845	16	5	open	open	ADJ
admet-1845	16	6	-	-	PUNCT
admet-1845	16	7	access	access	NOUN
admet-1845	16	8	article	article	NOUN
admet-1845	16	9	distributed	distribute	VERB
admet-1845	16	10	under	under	ADP
admet-1845	16	11	the	the	DET
admet-1845	16	12	terms	term	NOUN
admet-1845	16	13	and	and	CCONJ
admet-1845	16	14	conditions	condition	NOUN
admet-1845	16	15	of	of	ADP
admet-1845	16	16	the	the	DET
admet-1845	16	17	creative	creative	ADJ
admet-1845	16	18	commons	common	NOUN
admet-1845	16	19	attribution	attribution	NOUN
admet-1845	16	20	license	license	NOUN
admet-1845	16	21	(	(	PUNCT
admet-1845	16	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1845	16	23	)	)	PUNCT
admet-1845	16	24	.	.	PUNCT
admet-1845	17	1	keywords	keyword	VERB
admet-1845	17	2	chemotherapy	chemotherapy	NOUN
admet-1845	17	3	;	;	PUNCT
admet-1845	17	4	reactive	reactive	ADJ
admet-1845	17	5	oxygen	oxygen	NOUN
admet-1845	17	6	species	specie	NOUN
admet-1845	17	7	;	;	PUNCT
admet-1845	17	8	ros	ros	PROPN
admet-1845	17	9	scavengers	scavenger	NOUN
admet-1845	17	10	;	;	PUNCT
admet-1845	17	11	micelles	micelle	NOUN
admet-1845	17	12	nanoparticles	nanoparticle	NOUN
admet-1845	17	13	,	,	PUNCT
admet-1845	17	14	nanomedicine	nanomedicine	ADJ
admet-1845	17	15	introduction	introduction	NOUN
admet-1845	17	16	doxorubicin	doxorubicin	PROPN
admet-1845	17	17	(	(	PUNCT
admet-1845	17	18	dox	dox	NOUN
admet-1845	17	19	,	,	PUNCT
admet-1845	17	20	also	also	ADV
admet-1845	17	21	known	know	VERB
admet-1845	17	22	as	as	ADP
admet-1845	17	23	adriamycin	adriamycin	NOUN
admet-1845	17	24	)	)	PUNCT
admet-1845	17	25	has	have	AUX
admet-1845	17	26	been	be	AUX
admet-1845	17	27	widely	widely	ADV
admet-1845	17	28	used	use	VERB
admet-1845	17	29	to	to	PART
admet-1845	17	30	treat	treat	VERB
admet-1845	17	31	numerous	numerous	ADJ
admet-1845	17	32	cancer	cancer	NOUN
admet-1845	17	33	types	type	NOUN
admet-1845	17	34	since	since	SCONJ
admet-1845	17	35	its	its	PRON
admet-1845	17	36	approval	approval	NOUN
admet-1845	17	37	by	by	ADP
admet-1845	17	38	the	the	DET
admet-1845	17	39	fda	fda	PROPN
admet-1845	17	40	in	in	ADP
admet-1845	17	41	1974	1974	NUM
admet-1845	18	1	[	[	X
admet-1845	18	2	1	1	NUM
admet-1845	18	3	]	]	PUNCT
admet-1845	18	4	.	.	PUNCT
admet-1845	19	1	the	the	DET
admet-1845	19	2	most	most	ADV
admet-1845	19	3	well	well	ADV
admet-1845	19	4	-	-	PUNCT
admet-1845	19	5	known	know	VERB
admet-1845	19	6	anticancer	anticancer	NOUN
admet-1845	19	7	mechanism	mechanism	NOUN
admet-1845	19	8	of	of	ADP
admet-1845	19	9	dox	dox	NOUN
admet-1845	19	10	is	be	AUX
admet-1845	19	11	the	the	DET
admet-1845	19	12	interaction	interaction	NOUN
admet-1845	19	13	with	with	ADP
admet-1845	19	14	the	the	DET
admet-1845	19	15	topoisomerases	topoisomerases	PROPN
admet-1845	19	16	ii	ii	PROPN
admet-1845	19	17	,	,	PUNCT
admet-1845	19	18	leading	lead	VERB
admet-1845	19	19	to	to	PART
admet-1845	19	20	interference	interference	VERB
admet-1845	19	21	with	with	ADP
admet-1845	19	22	the	the	DET
admet-1845	19	23	dna	dna	PROPN
admet-1845	19	24	replications	replication	NOUN
admet-1845	19	25	.	.	PUNCT
admet-1845	20	1	additionally	additionally	ADV
admet-1845	20	2	,	,	PUNCT
admet-1845	20	3	dox	dox	NOUN
admet-1845	20	4	also	also	ADV
admet-1845	20	5	induces	induce	VERB
admet-1845	20	6	https://doi.org/10.5599/admet.1845	https://doi.org/10.5599/admet.1845	NOUN
admet-1845	20	7	https://doi.org/10.5599/admet.1845	https://doi.org/10.5599/admet.1845	NOUN
admet-1845	20	8	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1845	20	9	mailto:vblong@hcmiu.edu.vn	mailto:vblong@hcmiu.edu.vn	NOUN
admet-1845	20	10	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1845	20	11	m.-d	m.-d	PROPN
admet-1845	20	12	.	.	PUNCT
admet-1845	21	1	quoc	quoc	PROPN
admet-1845	21	2	tang	tang	INTJ
admet-1845	21	3	et	et	PROPN
admet-1845	21	4	al	al	PROPN
admet-1845	21	5	.	.	PROPN
admet-1845	21	6	admet	admet	PROPN
admet-1845	21	7	&	&	CCONJ
admet-1845	21	8	dmpk	dmpk	PROPN
admet-1845	21	9	11(4	11(4	NUM
admet-1845	21	10	)	)	PUNCT
admet-1845	21	11	(	(	PUNCT
admet-1845	21	12	2023	2023	NUM
admet-1845	21	13	)	)	PUNCT
admet-1845	21	14	551	551	NUM
admet-1845	21	15	-	-	SYM
admet-1845	21	16	560	560	NUM
admet-1845	21	17	552	552	NUM
admet-1845	21	18	reactive	reactive	ADJ
admet-1845	21	19	oxygen	oxygen	NOUN
admet-1845	21	20	species	specie	NOUN
admet-1845	21	21	(	(	PUNCT
admet-1845	21	22	ros	ros	PROPN
admet-1845	21	23	)	)	PUNCT
admet-1845	21	24	via	via	ADP
admet-1845	21	25	nonenzymatic	nonenzymatic	ADJ
admet-1845	21	26	and	and	CCONJ
admet-1845	21	27	enzymatic	enzymatic	ADJ
admet-1845	21	28	pathways	pathway	NOUN
admet-1845	22	1	[	[	X
admet-1845	22	2	2,3	2,3	NUM
admet-1845	22	3	]	]	PUNCT
admet-1845	22	4	.	.	PUNCT
admet-1845	23	1	consequently	consequently	ADV
admet-1845	23	2	,	,	PUNCT
admet-1845	23	3	these	these	DET
admet-1845	23	4	free	free	ADJ
admet-1845	23	5	radicals	radical	NOUN
admet-1845	23	6	cause	cause	VERB
admet-1845	23	7	intracellular	intracellular	ADJ
admet-1845	23	8	oxidative	oxidative	ADJ
admet-1845	23	9	stress	stress	NOUN
admet-1845	23	10	,	,	PUNCT
admet-1845	23	11	and	and	CCONJ
admet-1845	23	12	damage	damage	NOUN
admet-1845	23	13	cellular	cellular	ADJ
admet-1845	23	14	membranes	membrane	NOUN
admet-1845	23	15	and	and	CCONJ
admet-1845	23	16	dna	dna	NOUN
admet-1845	23	17	,	,	PUNCT
admet-1845	23	18	although	although	SCONJ
admet-1845	23	19	this	this	DET
admet-1845	23	20	mechanism	mechanism	NOUN
admet-1845	23	21	is	be	AUX
admet-1845	23	22	not	not	PART
admet-1845	23	23	considered	consider	VERB
admet-1845	23	24	to	to	PART
admet-1845	23	25	play	play	VERB
admet-1845	23	26	a	a	DET
admet-1845	23	27	major	major	ADJ
admet-1845	23	28	role	role	NOUN
admet-1845	23	29	in	in	ADP
admet-1845	23	30	killing	kill	VERB
admet-1845	23	31	cancer	cancer	NOUN
admet-1845	23	32	cells	cell	NOUN
admet-1845	23	33	[	[	X
admet-1845	23	34	4	4	NUM
admet-1845	23	35	]	]	PUNCT
admet-1845	23	36	.	.	PUNCT
admet-1845	24	1	unfortunately	unfortunately	ADV
admet-1845	24	2	,	,	PUNCT
admet-1845	24	3	dox	dox	NOUN
admet-1845	24	4	is	be	AUX
admet-1845	24	5	non	non	ADJ
admet-1845	24	6	-	-	ADJ
admet-1845	24	7	specific	specific	ADJ
admet-1845	24	8	distribution	distribution	NOUN
admet-1845	24	9	due	due	ADP
admet-1845	24	10	to	to	ADP
admet-1845	24	11	its	its	PRON
admet-1845	24	12	low	low	ADJ
admet-1845	24	13	molecular	molecular	ADJ
admet-1845	24	14	weight	weight	NOUN
admet-1845	24	15	drug	drug	NOUN
admet-1845	24	16	nature	nature	NOUN
admet-1845	24	17	,	,	PUNCT
admet-1845	24	18	resulting	result	VERB
admet-1845	24	19	in	in	ADP
admet-1845	24	20	myocyte	myocyte	PROPN
admet-1845	24	21	,	,	PUNCT
admet-1845	24	22	myelocyte	myelocyte	NOUN
admet-1845	24	23	,	,	PUNCT
admet-1845	24	24	and	and	CCONJ
admet-1845	24	25	hematocyte	hematocyte	NOUN
admet-1845	24	26	toxicities	toxicity	NOUN
admet-1845	24	27	[	[	X
admet-1845	24	28	5	5	NUM
admet-1845	24	29	-	-	SYM
admet-1845	24	30	7	7	NUM
admet-1845	24	31	]	]	PUNCT
admet-1845	24	32	.	.	PUNCT
admet-1845	25	1	dox	dox	NOUN
admet-1845	25	2	-	-	PUNCT
admet-1845	25	3	induced	induce	VERB
admet-1845	25	4	damage	damage	NOUN
admet-1845	25	5	on	on	ADP
admet-1845	25	6	intestinal	intestinal	ADJ
admet-1845	25	7	epithelium	epithelium	NOUN
admet-1845	25	8	has	have	AUX
admet-1845	25	9	also	also	ADV
admet-1845	25	10	been	be	AUX
admet-1845	25	11	reported	report	VERB
admet-1845	25	12	[	[	X
admet-1845	25	13	8	8	NUM
admet-1845	25	14	]	]	PUNCT
admet-1845	25	15	.	.	PUNCT
admet-1845	26	1	besides	besides	SCONJ
admet-1845	26	2	,	,	PUNCT
admet-1845	26	3	the	the	DET
admet-1845	26	4	low	low	ADJ
admet-1845	26	5	oral	oral	ADJ
admet-1845	26	6	bioavailability	bioavailability	NOUN
admet-1845	26	7	of	of	ADP
admet-1845	26	8	dox	dox	NOUN
admet-1845	26	9	was	be	AUX
admet-1845	26	10	reported	report	VERB
admet-1845	26	11	at	at	ADP
admet-1845	26	12	1	1	NUM
admet-1845	26	13	%	%	NOUN
admet-1845	26	14	due	due	ADP
admet-1845	26	15	to	to	ADP
admet-1845	26	16	its	its	PRON
admet-1845	26	17	absorption	absorption	NOUN
admet-1845	26	18	through	through	ADP
admet-1845	26	19	the	the	DET
admet-1845	26	20	paracellular	paracellular	ADJ
admet-1845	26	21	pathway	pathway	NOUN
admet-1845	26	22	[	[	X
admet-1845	26	23	9	9	NUM
admet-1845	26	24	]	]	PUNCT
admet-1845	26	25	.	.	PUNCT
admet-1845	27	1	lowering	lower	VERB
admet-1845	27	2	the	the	DET
admet-1845	27	3	cytotoxicity	cytotoxicity	NOUN
admet-1845	27	4	of	of	ADP
admet-1845	27	5	dox	dox	NOUN
admet-1845	27	6	and	and	CCONJ
admet-1845	27	7	enhancement	enhancement	NOUN
admet-1845	27	8	of	of	ADP
admet-1845	27	9	its	its	PRON
admet-1845	27	10	oral	oral	ADJ
admet-1845	27	11	bioavailability	bioavailability	NOUN
admet-1845	27	12	have	have	AUX
admet-1845	27	13	gained	gain	VERB
admet-1845	27	14	attention	attention	NOUN
admet-1845	27	15	to	to	PART
admet-1845	27	16	extend	extend	VERB
admet-1845	27	17	the	the	DET
admet-1845	27	18	clinical	clinical	ADJ
admet-1845	27	19	utility	utility	NOUN
admet-1845	27	20	of	of	ADP
admet-1845	27	21	dox	dox	NOUN
admet-1845	27	22	.	.	PUNCT
admet-1845	28	1	recently	recently	ADV
admet-1845	28	2	,	,	PUNCT
admet-1845	28	3	scavengers	scavenger	NOUN
admet-1845	28	4	of	of	ADP
admet-1845	28	5	free	free	ADJ
admet-1845	28	6	radicals	radical	NOUN
admet-1845	28	7	showed	show	VERB
admet-1845	28	8	prevention	prevention	NOUN
admet-1845	28	9	of	of	ADP
admet-1845	28	10	dox	dox	NOUN
admet-1845	28	11	-induced	-induce	VERB
admet-1845	28	12	cardiotoxicity	cardiotoxicity	NOUN
admet-1845	28	13	[	[	X
admet-1845	28	14	10	10	NUM
admet-1845	28	15	]	]	PUNCT
admet-1845	28	16	,	,	PUNCT
admet-1845	28	17	implying	imply	VERB
admet-1845	28	18	the	the	DET
admet-1845	28	19	important	important	ADJ
admet-1845	28	20	role	role	NOUN
admet-1845	28	21	of	of	ADP
admet-1845	28	22	ros	ros	PROPN
admet-1845	28	23	scavengers	scavenger	NOUN
admet-1845	28	24	in	in	ADP
admet-1845	28	25	reducing	reduce	VERB
admet-1845	28	26	the	the	DET
admet-1845	28	27	adverse	adverse	ADJ
admet-1845	28	28	effects	effect	NOUN
admet-1845	28	29	of	of	ADP
admet-1845	28	30	dox	dox	NOUN
admet-1845	28	31	.	.	PUNCT
admet-1845	29	1	nanoparticles	nanoparticle	NOUN
admet-1845	29	2	(	(	PUNCT
admet-1845	29	3	nps	nps	PROPN
admet-1845	29	4	)	)	PUNCT
admet-1845	29	5	have	have	AUX
admet-1845	29	6	been	be	AUX
admet-1845	29	7	widely	widely	ADV
admet-1845	29	8	developed	develop	VERB
admet-1845	29	9	as	as	ADP
admet-1845	29	10	carriers	carrier	NOUN
admet-1845	29	11	for	for	ADP
admet-1845	29	12	drug	drug	NOUN
admet-1845	29	13	delivery	delivery	NOUN
admet-1845	29	14	systems	system	NOUN
admet-1845	29	15	(	(	PUNCT
admet-1845	29	16	dds	dds	PROPN
admet-1845	29	17	)	)	PUNCT
admet-1845	29	18	to	to	PART
admet-1845	29	19	decrease	decrease	VERB
admet-1845	29	20	unwanted	unwanted	ADJ
admet-1845	29	21	diffusion	diffusion	NOUN
admet-1845	29	22	,	,	PUNCT
admet-1845	29	23	increase	increase	VERB
admet-1845	29	24	drug	drug	NOUN
admet-1845	29	25	bioavailability	bioavailability	NOUN
admet-1845	29	26	,	,	PUNCT
admet-1845	29	27	and	and	CCONJ
admet-1845	29	28	control	control	VERB
admet-1845	29	29	pharmacokinetics	pharmacokinetic	NOUN
admet-1845	30	1	[	[	X
admet-1845	30	2	11	11	NUM
admet-1845	30	3	-	-	SYM
admet-1845	30	4	13	13	NUM
admet-1845	30	5	]	]	PUNCT
admet-1845	30	6	.	.	PUNCT
admet-1845	31	1	oral	oral	ADJ
admet-1845	31	2	administration	administration	NOUN
admet-1845	31	3	is	be	AUX
admet-1845	31	4	one	one	NUM
admet-1845	31	5	of	of	ADP
admet-1845	31	6	the	the	DET
admet-1845	31	7	most	most	ADV
admet-1845	31	8	popular	popular	ADJ
admet-1845	31	9	pathways	pathway	NOUN
admet-1845	31	10	to	to	PART
admet-1845	31	11	deliver	deliver	VERB
admet-1845	31	12	nps	nps	PROPN
admet-1845	31	13	owing	owe	VERB
admet-1845	31	14	to	to	ADP
admet-1845	31	15	its	its	PRON
admet-1845	31	16	unique	unique	ADJ
admet-1845	31	17	advantages	advantage	NOUN
admet-1845	31	18	like	like	ADP
admet-1845	31	19	non	non	ADJ
admet-1845	31	20	-	-	NOUN
admet-1845	31	21	invasion	invasion	ADJ
admet-1845	31	22	,	,	PUNCT
admet-1845	31	23	painlessness	painlessness	NOUN
admet-1845	31	24	,	,	PUNCT
admet-1845	31	25	easy	easy	ADJ
admet-1845	31	26	administration	administration	NOUN
admet-1845	31	27	,	,	PUNCT
admet-1845	31	28	and	and	CCONJ
admet-1845	31	29	patient	patient	ADJ
admet-1845	31	30	compliance	compliance	NOUN
admet-1845	31	31	.	.	PUNCT
admet-1845	32	1	the	the	DET
admet-1845	32	2	various	various	ADJ
admet-1845	32	3	nps	nps	PROPN
admet-1845	32	4	,	,	PUNCT
admet-1845	32	5	such	such	ADJ
admet-1845	32	6	as	as	ADP
admet-1845	32	7	liposomes	liposome	NOUN
admet-1845	32	8	,	,	PUNCT
admet-1845	32	9	metal	metal	NOUN
admet-1845	32	10	,	,	PUNCT
admet-1845	32	11	and	and	CCONJ
admet-1845	32	12	polymeric	polymeric	ADJ
admet-1845	32	13	nps	nps	PROPN
admet-1845	32	14	,	,	PUNCT
admet-1845	32	15	have	have	AUX
admet-1845	32	16	been	be	AUX
admet-1845	32	17	designed	design	VERB
admet-1845	32	18	for	for	ADP
admet-1845	32	19	oral	oral	ADJ
admet-1845	32	20	drug	drug	NOUN
admet-1845	32	21	delivery	delivery	NOUN
admet-1845	32	22	.	.	PUNCT
admet-1845	33	1	however	however	ADV
admet-1845	33	2	,	,	PUNCT
admet-1845	33	3	most	most	ADJ
admet-1845	33	4	techniques	technique	NOUN
admet-1845	33	5	still	still	ADV
admet-1845	33	6	face	face	VERB
admet-1845	33	7	numerous	numerous	ADJ
admet-1845	33	8	challenges	challenge	NOUN
admet-1845	33	9	,	,	PUNCT
admet-1845	33	10	such	such	ADJ
admet-1845	33	11	as	as	ADP
admet-1845	33	12	gastric	gastric	ADJ
admet-1845	33	13	juice	juice	NOUN
admet-1845	33	14	influencing	influence	VERB
admet-1845	33	15	the	the	DET
admet-1845	33	16	aggregation	aggregation	NOUN
admet-1845	33	17	state	state	NOUN
admet-1845	33	18	of	of	ADP
admet-1845	33	19	liposomes	liposome	NOUN
admet-1845	33	20	[	[	X
admet-1845	33	21	14	14	NUM
admet-1845	33	22	]	]	PUNCT
admet-1845	33	23	,	,	PUNCT
admet-1845	33	24	decreasing	decrease	VERB
admet-1845	33	25	migration	migration	NOUN
admet-1845	33	26	,	,	PUNCT
admet-1845	33	27	retention	retention	NOUN
admet-1845	33	28	in	in	ADP
admet-1845	33	29	the	the	DET
admet-1845	33	30	intestinal	intestinal	ADJ
admet-1845	33	31	mucus	mucus	NOUN
admet-1845	33	32	layer	layer	NOUN
admet-1845	33	33	,	,	PUNCT
admet-1845	33	34	and	and	CCONJ
admet-1845	33	35	low	low	ADJ
admet-1845	33	36	blood	blood	NOUN
admet-1845	33	37	uptake	uptake	NOUN
admet-1845	33	38	of	of	ADP
admet-1845	33	39	the	the	DET
admet-1845	33	40	therapeutic	therapeutic	ADJ
admet-1845	33	41	agents	agent	NOUN
admet-1845	33	42	.	.	PUNCT
admet-1845	34	1	moreover	moreover	ADV
admet-1845	34	2	,	,	PUNCT
admet-1845	34	3	the	the	DET
admet-1845	34	4	activation	activation	NOUN
admet-1845	34	5	of	of	ADP
admet-1845	34	6	various	various	ADJ
admet-1845	34	7	enzymes	enzyme	NOUN
admet-1845	34	8	by	by	ADP
admet-1845	34	9	oral	oral	ADJ
admet-1845	34	10	administration	administration	NOUN
admet-1845	34	11	also	also	ADV
admet-1845	34	12	causes	cause	VERB
admet-1845	34	13	instability	instability	NOUN
admet-1845	34	14	and	and	CCONJ
admet-1845	34	15	leakage	leakage	NOUN
admet-1845	34	16	of	of	ADP
admet-1845	34	17	payload	payload	NOUN
admet-1845	34	18	,	,	PUNCT
admet-1845	34	19	suggesting	suggest	VERB
admet-1845	34	20	an	an	DET
admet-1845	34	21	efficient	efficient	ADJ
admet-1845	34	22	reduction	reduction	NOUN
admet-1845	34	23	of	of	ADP
admet-1845	34	24	drug	drug	NOUN
admet-1845	34	25	carriers	carrier	NOUN
admet-1845	34	26	and	and	CCONJ
admet-1845	34	27	toxicity	toxicity	NOUN
admet-1845	34	28	owing	owe	VERB
admet-1845	34	29	to	to	ADP
admet-1845	34	30	the	the	DET
admet-1845	34	31	exposure	exposure	NOUN
admet-1845	34	32	of	of	ADP
admet-1845	34	33	the	the	DET
admet-1845	34	34	drug	drug	NOUN
admet-1845	34	35	on	on	ADP
admet-1845	34	36	the	the	DET
admet-1845	34	37	gastrointestinal	gastrointestinal	ADJ
admet-1845	34	38	(	(	PUNCT
admet-1845	34	39	gi	gi	INTJ
admet-1845	34	40	)	)	PUNCT
admet-1845	34	41	tract	tract	NOUN
admet-1845	34	42	.	.	PUNCT
admet-1845	35	1	therefore	therefore	ADV
admet-1845	35	2	,	,	PUNCT
admet-1845	35	3	the	the	DET
admet-1845	35	4	requirements	requirement	NOUN
admet-1845	35	5	for	for	ADP
admet-1845	35	6	oral	oral	ADJ
admet-1845	35	7	dds	dds	PROPN
admet-1845	35	8	of	of	ADP
admet-1845	35	9	cancer	cancer	NOUN
admet-1845	35	10	treatment	treatment	NOUN
admet-1845	35	11	are	be	AUX
admet-1845	35	12	stable	stable	ADJ
admet-1845	35	13	dispersion	dispersion	NOUN
admet-1845	35	14	,	,	PUNCT
admet-1845	35	15	drug	drug	NOUN
admet-1845	35	16	encapsulation	encapsulation	NOUN
admet-1845	35	17	in	in	ADP
admet-1845	35	18	the	the	DET
admet-1845	35	19	harsh	harsh	ADJ
admet-1845	35	20	gi	gi	NOUN
admet-1845	35	21	tract	tract	NOUN
admet-1845	35	22	,	,	PUNCT
admet-1845	35	23	and	and	CCONJ
admet-1845	35	24	low	low	ADJ
admet-1845	35	25	toxicity	toxicity	NOUN
admet-1845	35	26	.	.	PUNCT
admet-1845	36	1	recently	recently	ADV
admet-1845	36	2	,	,	PUNCT
admet-1845	36	3	polymeric	polymeric	ADJ
admet-1845	36	4	nps	nps	PROPN
admet-1845	36	5	have	have	AUX
admet-1845	36	6	been	be	AUX
admet-1845	36	7	applied	apply	VERB
admet-1845	36	8	to	to	PART
admet-1845	36	9	improve	improve	VERB
admet-1845	36	10	the	the	DET
admet-1845	36	11	oral	oral	ADJ
admet-1845	36	12	bioavailability	bioavailability	NOUN
admet-1845	36	13	of	of	ADP
admet-1845	36	14	chemotherapy	chemotherapy	NOUN
admet-1845	36	15	.	.	PUNCT
admet-1845	37	1	for	for	ADP
admet-1845	37	2	example	example	NOUN
admet-1845	37	3	,	,	PUNCT
admet-1845	37	4	dox	dox	NOUN
admet-1845	37	5	-	-	PUNCT
admet-1845	37	6	encapsulated	encapsulate	VERB
admet-1845	37	7	enoxaparin	enoxaparin	NOUN
admet-1845	37	8	sodium	sodium	NOUN
admet-1845	37	9	-	-	PUNCT
admet-1845	37	10	plga	plga	NOUN
admet-1845	37	11	hybrid	hybrid	ADJ
admet-1845	37	12	nps	nps	PROPN
admet-1845	37	13	significantly	significantly	ADV
admet-1845	37	14	increased	increase	VERB
admet-1845	37	15	retention	retention	NOUN
admet-1845	37	16	time	time	NOUN
admet-1845	37	17	in	in	ADP
admet-1845	37	18	the	the	DET
admet-1845	37	19	pharmacokinetics	pharmacokinetic	NOUN
admet-1845	37	20	study	study	NOUN
admet-1845	37	21	[	[	X
admet-1845	37	22	15	15	NUM
admet-1845	37	23	]	]	PUNCT
admet-1845	37	24	.	.	PUNCT
admet-1845	38	1	moreover	moreover	ADV
admet-1845	38	2	,	,	PUNCT
admet-1845	38	3	polymeric	polymeric	ADJ
admet-1845	38	4	micelles	micelle	NOUN
admet-1845	38	5	,	,	PUNCT
admet-1845	38	6	a	a	DET
admet-1845	38	7	type	type	NOUN
admet-1845	38	8	of	of	ADP
admet-1845	38	9	polymeric	polymeric	ADJ
admet-1845	38	10	nps	nps	PROPN
admet-1845	38	11	with	with	ADP
admet-1845	38	12	a	a	DET
admet-1845	38	13	core	core	ADJ
admet-1845	38	14	-	-	PUNCT
admet-1845	38	15	shell	shell	NOUN
admet-1845	38	16	structure	structure	NOUN
admet-1845	38	17	,	,	PUNCT
admet-1845	38	18	can	can	AUX
admet-1845	38	19	increase	increase	VERB
admet-1845	38	20	the	the	DET
admet-1845	38	21	stability	stability	NOUN
admet-1845	38	22	,	,	PUNCT
admet-1845	38	23	and	and	CCONJ
admet-1845	38	24	permeability	permeability	NOUN
admet-1845	38	25	in	in	ADP
admet-1845	38	26	the	the	DET
admet-1845	38	27	intestinal	intestinal	ADJ
admet-1845	38	28	epithelium	epithelium	NOUN
admet-1845	38	29	and	and	CCONJ
admet-1845	38	30	reduce	reduce	VERB
admet-1845	38	31	the	the	DET
admet-1845	38	32	degradation	degradation	NOUN
admet-1845	38	33	of	of	ADP
admet-1845	38	34	anti	anti	ADJ
admet-1845	38	35	-	-	ADJ
admet-1845	38	36	cancer	cancer	ADJ
admet-1845	38	37	drugs	drug	NOUN
admet-1845	38	38	.	.	PUNCT
admet-1845	39	1	for	for	ADP
admet-1845	39	2	instance	instance	NOUN
admet-1845	39	3	,	,	PUNCT
admet-1845	39	4	dox	dox	NOUN
admet-1845	39	5	-	-	PUNCT
admet-1845	39	6	loaded	load	VERB
admet-1845	39	7	polymeric	polymeric	ADJ
admet-1845	39	8	micelles	micelle	NOUN
admet-1845	39	9	significantly	significantly	ADV
admet-1845	39	10	improved	improve	VERB
admet-1845	39	11	the	the	DET
admet-1845	39	12	intestinal	intestinal	ADJ
admet-1845	39	13	absorption	absorption	NOUN
admet-1845	39	14	rate	rate	NOUN
admet-1845	39	15	and	and	CCONJ
admet-1845	39	16	systemic	systemic	ADJ
admet-1845	39	17	circulation	circulation	NOUN
admet-1845	39	18	time	time	NOUN
admet-1845	39	19	as	as	SCONJ
admet-1845	39	20	compared	compare	VERB
admet-1845	39	21	to	to	ADP
admet-1845	39	22	free	free	ADJ
admet-1845	39	23	dox	dox	NOUN
admet-1845	39	24	[	[	X
admet-1845	39	25	16	16	NUM
admet-1845	39	26	]	]	PUNCT
admet-1845	39	27	.	.	PUNCT
admet-1845	40	1	thus	thus	ADV
admet-1845	40	2	,	,	PUNCT
admet-1845	40	3	micelles	micelle	NOUN
admet-1845	40	4	nps	nps	PROPN
admet-1845	40	5	can	can	AUX
admet-1845	40	6	be	be	AUX
admet-1845	40	7	considered	consider	VERB
admet-1845	40	8	potential	potential	ADJ
admet-1845	40	9	anti	anti	ADJ
admet-1845	40	10	-	-	ADJ
admet-1845	40	11	cancer	cancer	ADJ
admet-1845	40	12	dds	dds	PROPN
admet-1845	40	13	in	in	ADP
admet-1845	40	14	oral	oral	ADJ
admet-1845	40	15	administration	administration	NOUN
admet-1845	40	16	.	.	PUNCT
admet-1845	41	1	recently	recently	ADV
admet-1845	41	2	,	,	PUNCT
admet-1845	41	3	we	we	PRON
admet-1845	41	4	have	have	AUX
admet-1845	41	5	designed	design	VERB
admet-1845	41	6	two	two	NUM
admet-1845	41	7	types	type	NOUN
admet-1845	41	8	of	of	ADP
admet-1845	41	9	core	core	NOUN
admet-1845	41	10	-	-	PUNCT
admet-1845	41	11	shell	shell	NOUN
admet-1845	41	12	antioxidant	antioxidant	ADJ
admet-1845	41	13	nps	nps	PROPN
admet-1845	41	14	,	,	PUNCT
admet-1845	41	15	ph	ph	ADJ
admet-1845	41	16	non	non	ADJ
admet-1845	41	17	-	-	ADJ
admet-1845	41	18	sensitive	sensitive	ADJ
admet-1845	41	19	(	(	PUNCT
admet-1845	41	20	rnpo	rnpo	NOUN
admet-1845	41	21	)	)	PUNCT
admet-1845	41	22	and	and	CCONJ
admet-1845	41	23	phsensitive	phsensitive	ADJ
admet-1845	41	24	(	(	PUNCT
admet-1845	41	25	rnpn	rnpn	PROPN
admet-1845	41	26	)	)	PUNCT
admet-1845	41	27	,	,	PUNCT
admet-1845	41	28	as	as	SCONJ
admet-1845	41	29	ideal	ideal	ADJ
admet-1845	41	30	oral	oral	ADJ
admet-1845	41	31	dds	dds	PROPN
admet-1845	41	32	to	to	PART
admet-1845	41	33	solve	solve	VERB
admet-1845	41	34	these	these	DET
admet-1845	41	35	problems	problem	NOUN
admet-1845	41	36	.	.	PUNCT
admet-1845	42	1	rnpo	rnpo	ADJ
admet-1845	42	2	and	and	CCONJ
admet-1845	42	3	rnpn	rnpn	NOUN
admet-1845	42	4	were	be	AUX
admet-1845	42	5	prepared	prepare	VERB
admet-1845	42	6	through	through	ADP
admet-1845	42	7	selfassembly	selfassembly	ADV
admet-1845	42	8	amphiphilic	amphiphilic	ADJ
admet-1845	42	9	block	block	NOUN
admet-1845	42	10	copolymers	copolymer	NOUN
admet-1845	42	11	containing	contain	VERB
admet-1845	42	12	ros	ros	PROPN
admet-1845	42	13	scavengers	scavenger	NOUN
admet-1845	42	14	(	(	PUNCT
admet-1845	42	15	nitroxide	nitroxide	NOUN
admet-1845	42	16	radicals	radical	NOUN
admet-1845	42	17	,	,	PUNCT
admet-1845	42	18	tempo	tempo	PROPN
admet-1845	42	19	)	)	PUNCT
admet-1845	42	20	at	at	ADP
admet-1845	42	21	the	the	DET
admet-1845	42	22	side	side	NOUN
admet-1845	42	23	chains	chain	NOUN
admet-1845	42	24	of	of	ADP
admet-1845	42	25	the	the	DET
admet-1845	42	26	hydrophobic	hydrophobic	NOUN
admet-1845	42	27	segment	segment	NOUN
admet-1845	42	28	.	.	PUNCT
admet-1845	43	1	the	the	DET
admet-1845	43	2	ros	ros	PROPN
admet-1845	43	3	-	-	PUNCT
admet-1845	43	4	scavenging	scavenge	VERB
admet-1845	43	5	ability	ability	NOUN
admet-1845	43	6	of	of	ADP
admet-1845	43	7	rnps	rnps	PROPN
admet-1845	43	8	is	be	AUX
admet-1845	43	9	an	an	DET
admet-1845	43	10	important	important	ADJ
admet-1845	43	11	factor	factor	NOUN
admet-1845	43	12	in	in	ADP
admet-1845	43	13	decreasing	decrease	VERB
admet-1845	43	14	the	the	DET
admet-1845	43	15	dox	dox	NOUN
admet-1845	43	16	-	-	PUNCT
admet-1845	43	17	induced	induce	VERB
admet-1845	43	18	oxidation	oxidation	NOUN
admet-1845	43	19	stress	stress	NOUN
admet-1845	43	20	.	.	PUNCT
admet-1845	44	1	both	both	DET
admet-1845	44	2	rnps	rnps	PROPN
admet-1845	44	3	indicated	indicate	VERB
admet-1845	44	4	highly	highly	ADV
admet-1845	44	5	dispersible	dispersible	ADJ
admet-1845	44	6	and	and	CCONJ
admet-1845	44	7	biocompatible	biocompatible	ADJ
admet-1845	44	8	properties	property	NOUN
admet-1845	44	9	with	with	ADP
admet-1845	44	10	a	a	DET
admet-1845	44	11	long	long	ADJ
admet-1845	44	12	half	half	ADJ
admet-1845	44	13	-	-	PUNCT
admet-1845	44	14	life	life	NOUN
admet-1845	44	15	in	in	ADP
admet-1845	44	16	circulation	circulation	NOUN
admet-1845	44	17	compared	compare	VERB
admet-1845	44	18	to	to	ADP
admet-1845	44	19	free	free	ADJ
admet-1845	44	20	nitroxide	nitroxide	NOUN
admet-1845	44	21	radicals	radical	NOUN
admet-1845	44	22	.	.	PUNCT
admet-1845	45	1	in	in	ADP
admet-1845	45	2	addition	addition	NOUN
admet-1845	45	3	,	,	PUNCT
admet-1845	45	4	rnps	rnps	PROPN
admet-1845	45	5	have	have	AUX
admet-1845	45	6	be	be	AUX
admet-1845	45	7	en	en	ADV
admet-1845	45	8	researched	research	VERB
admet-1845	45	9	as	as	ADP
admet-1845	45	10	possible	possible	ADJ
admet-1845	45	11	treatments	treatment	NOUN
admet-1845	45	12	for	for	ADP
admet-1845	45	13	solid	solid	ADJ
admet-1845	45	14	tumours	tumour	NOUN
admet-1845	46	1	[	[	X
admet-1845	46	2	17,18	17,18	X
admet-1845	46	3	]	]	X
admet-1845	46	4	.	.	PUNCT
admet-1845	47	1	although	although	SCONJ
admet-1845	47	2	rnpo	rnpo	ADJ
admet-1845	47	3	prolonged	prolonged	ADJ
admet-1845	47	4	blood	blood	NOUN
admet-1845	47	5	circulation	circulation	NOUN
admet-1845	47	6	as	as	SCONJ
admet-1845	47	7	compared	compare	VERB
admet-1845	47	8	to	to	PART
admet-1845	47	9	rnpn	rnpn	VERB
admet-1845	47	10	[	[	PRON
admet-1845	47	11	19,20	19,20	NOUN
admet-1845	47	12	]	]	PUNCT
admet-1845	47	13	,	,	PUNCT
admet-1845	47	14	rnpo	rnpo	PROPN
admet-1845	47	15	was	be	AUX
admet-1845	47	16	not	not	PART
admet-1845	47	17	appropriated	appropriate	VERB
admet-1845	47	18	in	in	ADP
admet-1845	47	19	encapsulating	encapsulate	VERB
admet-1845	47	20	drugs	drug	NOUN
admet-1845	47	21	inside	inside	ADP
admet-1845	47	22	the	the	DET
admet-1845	47	23	core	core	NOUN
admet-1845	47	24	[	[	X
admet-1845	47	25	21	21	NUM
admet-1845	47	26	]	]	PUNCT
admet-1845	47	27	.	.	PUNCT
admet-1845	48	1	in	in	ADP
admet-1845	48	2	contrast	contrast	NOUN
admet-1845	48	3	,	,	PUNCT
admet-1845	48	4	gastric	gastric	ADJ
admet-1845	48	5	ph	ph	NOUN
admet-1845	48	6	is	be	AUX
admet-1845	48	7	also	also	ADV
admet-1845	48	8	challenging	challenge	VERB
admet-1845	48	9	for	for	ADP
admet-1845	48	10	rnpn	rnpn	NOUN
admet-1845	48	11	due	due	ADP
admet-1845	48	12	to	to	ADP
admet-1845	48	13	its	its	PRON
admet-1845	48	14	ph	ph	ADJ
admet-1845	48	15	sensitivity	sensitivity	NOUN
admet-1845	48	16	caused	cause	VERB
admet-1845	48	17	by	by	ADP
admet-1845	48	18	the	the	DET
admet-1845	48	19	protonation	protonation	NOUN
admet-1845	48	20	of	of	ADP
admet-1845	48	21	amino	amino	ADJ
admet-1845	48	22	groups	group	NOUN
admet-1845	48	23	on	on	ADP
admet-1845	48	24	the	the	DET
admet-1845	48	25	hydrophobic	hydrophobic	NOUN
admet-1845	48	26	core	core	NOUN
admet-1845	48	27	.	.	PUNCT
admet-1845	49	1	therefore	therefore	ADV
admet-1845	49	2	,	,	PUNCT
admet-1845	49	3	we	we	PRON
admet-1845	49	4	have	have	AUX
admet-1845	49	5	developed	develop	VERB
admet-1845	49	6	silica	silica	NOUN
admet-1845	49	7	-	-	PUNCT
admet-1845	49	8	installed	instal	VERB
admet-1845	49	9	redox	redox	PROPN
admet-1845	49	10	nps	nps	PROPN
admet-1845	49	11	(	(	PUNCT
admet-1845	49	12	sirnp	sirnp	PROPN
admet-1845	49	13	)	)	PUNCT
admet-1845	49	14	through	through	ADP
admet-1845	49	15	sol	sol	NOUN
admet-1845	49	16	-	-	PUNCT
admet-1845	49	17	gel	gel	NOUN
admet-1845	49	18	chemistry	chemistry	NOUN
admet-1845	49	19	by	by	ADP
admet-1845	49	20	the	the	DET
admet-1845	49	21	hydrolysis	hydrolysis	NOUN
admet-1845	49	22	and	and	CCONJ
admet-1845	49	23	condensation	condensation	NOUN
admet-1845	49	24	of	of	ADP
admet-1845	49	25	tetraethyl	tetraethyl	PROPN
admet-1845	49	26	orthosilicate	orthosilicate	PROPN
admet-1845	49	27	(	(	PUNCT
admet-1845	49	28	teos	teo	NOUN
admet-1845	49	29	)	)	PUNCT
admet-1845	49	30	with	with	ADP
admet-1845	49	31	the	the	DET
admet-1845	49	32	presence	presence	NOUN
admet-1845	49	33	of	of	ADP
admet-1845	49	34	ammonia	ammonia	NOUN
admet-1845	49	35	during	during	ADP
admet-1845	49	36	the	the	DET
admet-1845	49	37	preparation	preparation	NOUN
admet-1845	49	38	of	of	ADP
admet-1845	49	39	rnpn	rnpn	NOUN
admet-1845	49	40	.	.	PUNCT
admet-1845	50	1	crosslinking	crosslinke	VERB
admet-1845	50	2	of	of	ADP
admet-1845	50	3	silanol	silanol	NOUN
admet-1845	50	4	groups	group	NOUN
admet-1845	50	5	is	be	AUX
admet-1845	50	6	expected	expect	VERB
admet-1845	50	7	to	to	PART
admet-1845	50	8	improve	improve	VERB
admet-1845	50	9	the	the	DET
admet-1845	50	10	stability	stability	NOUN
admet-1845	50	11	of	of	ADP
admet-1845	50	12	nps	nps	PROPN
admet-1845	50	13	and	and	CCONJ
admet-1845	50	14	the	the	DET
admet-1845	50	15	drug	drug	NOUN
admet-1845	50	16	encapsulation	encapsulation	NOUN
admet-1845	50	17	efficacy	efficacy	NOUN
admet-1845	50	18	via	via	ADP
admet-1845	50	19	adsorption	adsorption	NOUN
admet-1845	50	20	on	on	ADP
admet-1845	50	21	the	the	DET
admet-1845	50	22	silica	silica	NOUN
admet-1845	50	23	surface	surface	NOUN
admet-1845	50	24	and	and	CCONJ
admet-1845	50	25	electrostatic	electrostatic	ADJ
admet-1845	50	26	interactions	interaction	NOUN
admet-1845	50	27	between	between	ADP
admet-1845	50	28	dox	dox	NOUN
admet-1845	50	29	and	and	CCONJ
admet-1845	50	30	silica	silica	NOUN
admet-1845	50	31	.	.	PUNCT
admet-1845	51	1	in	in	ADP
admet-1845	51	2	this	this	DET
admet-1845	51	3	work	work	NOUN
admet-1845	51	4	,	,	PUNCT
admet-1845	51	5	we	we	PRON
admet-1845	51	6	studied	study	VERB
admet-1845	51	7	the	the	DET
admet-1845	51	8	impacts	impact	NOUN
admet-1845	51	9	of	of	ADP
admet-1845	51	10	rnpn	rnpn	NOUN
admet-1845	51	11	and	and	CCONJ
admet-1845	51	12	sirnp	sirnp	PROPN
admet-1845	51	13	loading	load	VERB
admet-1845	51	14	dox	dox	NOUN
admet-1845	51	15	(	(	PUNCT
admet-1845	51	16	denoted	denote	VERB
admet-1845	51	17	as	as	ADP
admet-1845	51	18	dox@rnpn	dox@rnpn	NOUN
admet-1845	51	19	and	and	CCONJ
admet-1845	51	20	dox@sirnp	dox@sirnp	PROPN
admet-1845	51	21	,	,	PUNCT
admet-1845	51	22	respectively	respectively	ADV
admet-1845	51	23	)	)	PUNCT
admet-1845	51	24	to	to	PART
admet-1845	51	25	reduce	reduce	VERB
admet-1845	51	26	the	the	DET
admet-1845	51	27	side	side	NOUN
admet-1845	51	28	effects	effect	NOUN
admet-1845	51	29	of	of	ADP
admet-1845	51	30	dox	dox	NOUN
admet-1845	51	31	on	on	ADP
admet-1845	51	32	normal	normal	ADJ
admet-1845	51	33	cells	cell	NOUN
admet-1845	51	34	and	and	CCONJ
admet-1845	51	35	to	to	PART
admet-1845	51	36	maintain	maintain	VERB
admet-1845	51	37	the	the	DET
admet-1845	51	38	cytotoxicity	cytotoxicity	NOUN
admet-1845	51	39	properties	property	NOUN
admet-1845	51	40	of	of	ADP
admet-1845	51	41	dox	dox	NOUN
admet-1845	51	42	on	on	ADP
admet-1845	51	43	cancer	cancer	NOUN
admet-1845	51	44	cells	cell	NOUN
admet-1845	51	45	.	.	PUNCT
admet-1845	52	1	the	the	DET
admet-1845	52	2	obtained	obtain	VERB
admet-1845	52	3	result	result	NOUN
admet-1845	52	4	indicated	indicate	VERB
admet-1845	52	5	that	that	SCONJ
admet-1845	52	6	nps	nps	PROPN
admet-1845	52	7	were	be	AUX
admet-1845	52	8	nano	nano	NOUN
admet-1845	52	9	-	-	PUNCT
admet-1845	52	10	size	size	NOUN
admet-1845	52	11	distribution	distribution	NOUN
admet-1845	52	12	and	and	CCONJ
admet-1845	52	13	high	high	ADJ
admet-1845	52	14	dispersion	dispersion	NOUN
admet-1845	52	15	in	in	ADP
admet-1845	52	16	the	the	DET
admet-1845	52	17	physiological	physiological	ADJ
admet-1845	52	18	conditions	condition	NOUN
admet-1845	52	19	.	.	PUNCT
admet-1845	53	1	moreover	moreover	ADV
admet-1845	53	2	,	,	PUNCT
admet-1845	53	3	the	the	DET
admet-1845	53	4	addition	addition	NOUN
admet-1845	53	5	of	of	ADP
admet-1845	53	6	silanol	silanol	NOUN
admet-1845	53	7	groups	group	NOUN
admet-1845	53	8	significantly	significantly	ADV
admet-1845	53	9	improved	improve	VERB
admet-1845	53	10	the	the	DET
admet-1845	53	11	encapsulation	encapsulation	NOUN
admet-1845	53	12	of	of	ADP
admet-1845	53	13	dox	dox	NOUN
admet-1845	53	14	and	and	CCONJ
admet-1845	53	15	the	the	DET
admet-1845	53	16	stability	stability	NOUN
admet-1845	53	17	of	of	ADP
admet-1845	53	18	rnpn	rnpn	NOUN
admet-1845	53	19	in	in	ADP
admet-1845	53	20	gastric	gastric	ADJ
admet-1845	53	21	ph	ph	NOUN
admet-1845	53	22	.	.	PROPN
admet-1845	53	23	compared	compare	VERB
admet-1845	53	24	to	to	ADP
admet-1845	53	25	free	free	ADJ
admet-1845	53	26	dox	dox	NOUN
admet-1845	53	27	treatment	treatment	NOUN
admet-1845	53	28	,	,	PUNCT
admet-1845	53	29	the	the	DET
admet-1845	53	30	dox@rnpn	dox@rnpn	NOUN
admet-1845	53	31	and	and	CCONJ
admet-1845	53	32	dox@sirnp	dox@sirnp	PROPN
admet-1845	53	33	showed	show	VERB
admet-1845	53	34	admet	admet	PROPN
admet-1845	53	35	&	&	CCONJ
admet-1845	53	36	dmpk	dmpk	PROPN
admet-1845	53	37	11(4	11(4	NUM
admet-1845	53	38	)	)	PUNCT
admet-1845	53	39	(	(	PUNCT
admet-1845	53	40	2023	2023	NUM
admet-1845	53	41	)	)	PUNCT
admet-1845	53	42	551	551	NUM
admet-1845	53	43	-	-	SYM
admet-1845	53	44	560	560	NUM
admet-1845	53	45	drug	drug	NOUN
admet-1845	53	46	encapsulation	encapsulation	NOUN
admet-1845	53	47	and	and	CCONJ
admet-1845	53	48	suppress	suppress	VERB
admet-1845	53	49	the	the	DET
admet-1845	53	50	adverse	adverse	ADJ
admet-1845	53	51	effect	effect	NOUN
admet-1845	53	52	of	of	ADP
admet-1845	53	53	doxorubicin	doxorubicin	PROPN
admet-1845	53	54	doi	doi	PROPN
admet-1845	53	55	:	:	PUNCT
admet-1845	53	56	https://doi.org/10.5599/adme	https://doi.org/10.5599/adme	NOUN
admet-1845	53	57	t.1845	t.1845	NOUN
admet-1845	53	58	553	553	NUM
admet-1845	53	59	lower	low	ADJ
admet-1845	53	60	cytotoxicity	cytotoxicity	NOUN
admet-1845	53	61	against	against	ADP
admet-1845	53	62	murine	murine	ADJ
admet-1845	53	63	fibroblast	fibroblast	ADJ
admet-1845	53	64	cells	cell	NOUN
admet-1845	53	65	(	(	PUNCT
admet-1845	53	66	l929	l929	NUM
admet-1845	53	67	)	)	PUNCT
admet-1845	53	68	,	,	PUNCT
admet-1845	53	69	while	while	SCONJ
admet-1845	53	70	they	they	PRON
admet-1845	53	71	maintained	maintain	VERB
admet-1845	53	72	the	the	DET
admet-1845	53	73	cytotoxicity	cytotoxicity	NOUN
admet-1845	53	74	on	on	ADP
admet-1845	53	75	human	human	ADJ
admet-1845	53	76	breast	breast	NOUN
admet-1845	53	77	cancer	cancer	NOUN
admet-1845	53	78	cells	cell	NOUN
admet-1845	53	79	(	(	PUNCT
admet-1845	53	80	mcf-7	mcf-7	NOUN
admet-1845	53	81	)	)	PUNCT
admet-1845	53	82	and	and	CCONJ
admet-1845	53	83	human	human	ADJ
admet-1845	53	84	hepatocellular	hepatocellular	ADJ
admet-1845	53	85	carcinoma	carcinoma	NOUN
admet-1845	53	86	cells	cell	NOUN
admet-1845	53	87	(	(	PUNCT
admet-1845	53	88	hepg2	hepg2	NOUN
admet-1845	53	89	)	)	PUNCT
admet-1845	53	90	.	.	PUNCT
admet-1845	54	1	experimental	experimental	ADJ
admet-1845	54	2	chemicals	chemical	NOUN
admet-1845	54	3	dimethylformamide	dimethylformamide	NOUN
admet-1845	54	4	(	(	PUNCT
admet-1845	54	5	dmf	dmf	PROPN
admet-1845	54	6	,	,	PUNCT
admet-1845	54	7	sigma	sigma	PROPN
admet-1845	54	8	-	-	PUNCT
admet-1845	54	9	aldrich	aldrich	PROPN
admet-1845	54	10	,	,	PUNCT
admet-1845	54	11	usa	usa	PROPN
admet-1845	54	12	)	)	PUNCT
admet-1845	54	13	,	,	PUNCT
admet-1845	54	14	permeable	permeable	ADJ
admet-1845	54	15	membrane	membrane	NOUN
admet-1845	54	16	tube	tube	NOUN
admet-1845	54	17	(	(	PUNCT
admet-1845	54	18	mwco	mwco	NOUN
admet-1845	54	19	3.5	3.5	NUM
admet-1845	54	20	kda	kda	NOUN
admet-1845	54	21	,	,	PUNCT
admet-1845	54	22	spectrum	spectrum	PROPN
admet-1845	54	23	laboratories	laboratories	PROPN
admet-1845	54	24	inc	inc	PROPN
admet-1845	54	25	.	.	PROPN
admet-1845	54	26	,	,	PUNCT
admet-1845	54	27	japan	japan	PROPN
admet-1845	54	28	)	)	PUNCT
admet-1845	54	29	,	,	PUNCT
admet-1845	54	30	tetraethyl	tetraethyl	PROPN
admet-1845	54	31	orthosilicate	orthosilicate	PROPN
admet-1845	54	32	(	(	PUNCT
admet-1845	54	33	teos	teos	PROPN
admet-1845	54	34	,	,	PUNCT
admet-1845	54	35	sigma	sigma	PROPN
admet-1845	54	36	-	-	PUNCT
admet-1845	54	37	aldrich	aldrich	PROPN
admet-1845	54	38	,	,	PUNCT
admet-1845	54	39	usa	usa	PROPN
admet-1845	54	40	)	)	PUNCT
admet-1845	54	41	,	,	PUNCT
admet-1845	54	42	ammonia	ammonia	NOUN
admet-1845	54	43	(	(	PUNCT
admet-1845	54	44	nh3	nh3	PROPN
admet-1845	54	45	,	,	PUNCT
admet-1845	54	46	china	china	PROPN
admet-1845	54	47	)	)	PUNCT
admet-1845	54	48	,	,	PUNCT
admet-1845	54	49	doxorubicin	doxorubicin	PROPN
admet-1845	54	50	hydrochloride	hydrochloride	NOUN
admet-1845	54	51	(	(	PUNCT
admet-1845	54	52	dox	dox	NOUN
admet-1845	54	53	,	,	PUNCT
admet-1845	54	54	wako	wako	PROPN
admet-1845	54	55	,	,	PUNCT
admet-1845	54	56	japan	japan	PROPN
admet-1845	54	57	)	)	PUNCT
admet-1845	54	58	,	,	PUNCT
admet-1845	54	59	3-(4,5	3-(4,5	PROPN
admet-1845	54	60	-	-	PUNCT
admet-1845	54	61	dimethylthiazol-2	dimethylthiazol-2	NUM
admet-1845	54	62	-	-	PUNCT
admet-1845	54	63	yl)-2,5	yl)-2,5	NOUN
admet-1845	54	64	-	-	PUNCT
admet-1845	54	65	diphenyltetrazolium	diphenyltetrazolium	NOUN
admet-1845	54	66	bromide	bromide	NOUN
admet-1845	54	67	(	(	PUNCT
admet-1845	54	68	mtt	mtt	X
admet-1845	54	69	,	,	PUNCT
admet-1845	54	70	roche	roche	NOUN
admet-1845	54	71	diagnostics	diagnostic	NOUN
admet-1845	54	72	,	,	PUNCT
admet-1845	54	73	japan	japan	PROPN
admet-1845	54	74	)	)	PUNCT
admet-1845	54	75	,	,	PUNCT
admet-1845	54	76	dimethyl	dimethyl	NOUN
admet-1845	54	77	sulfoxide	sulfoxide	NOUN
admet-1845	54	78	(	(	PUNCT
admet-1845	54	79	dmso	dmso	NOUN
admet-1845	54	80	,	,	PUNCT
admet-1845	54	81	china	china	PROPN
admet-1845	54	82	)	)	PUNCT
admet-1845	54	83	,	,	PUNCT
admet-1845	54	84	dulbecco	dulbecco	NOUN
admet-1845	54	85	’s	’s	PART
admet-1845	54	86	modified	modified	PROPN
admet-1845	54	87	eagle	eagle	PROPN
admet-1845	54	88	’s	’s	PART
admet-1845	54	89	medium	medium	NOUN
admet-1845	54	90	(	(	PUNCT
admet-1845	54	91	dmem	dmem	ADJ
admet-1845	54	92	,	,	PUNCT
admet-1845	54	93	gibco	gibco	NOUN
admet-1845	54	94	,	,	PUNCT
admet-1845	54	95	usa	usa	PROPN
admet-1845	54	96	)	)	PUNCT
admet-1845	54	97	,	,	PUNCT
admet-1845	54	98	fetal	fetal	ADJ
admet-1845	54	99	bovine	bovine	NOUN
admet-1845	54	100	serum	serum	NOUN
admet-1845	54	101	(	(	PUNCT
admet-1845	54	102	fbs	fbs	PROPN
admet-1845	54	103	,	,	PUNCT
admet-1845	54	104	sigma	sigma	PROPN
admet-1845	54	105	-	-	PUNCT
admet-1845	54	106	aldrich	aldrich	PROPN
admet-1845	54	107	,	,	PUNCT
admet-1845	54	108	usa	usa	PROPN
admet-1845	54	109	)	)	PUNCT
admet-1845	54	110	,	,	PUNCT
admet-1845	54	111	and	and	CCONJ
admet-1845	54	112	antibiotics	antibiotic	NOUN
admet-1845	54	113	(	(	PUNCT
admet-1845	54	114	a	a	DET
admet-1845	54	115	mixture	mixture	NOUN
admet-1845	54	116	of	of	ADP
admet-1845	54	117	penicillin	penicillin	NOUN
admet-1845	54	118	,	,	PUNCT
admet-1845	54	119	streptomycin	streptomycin	PROPN
admet-1845	54	120	,	,	PUNCT
admet-1845	54	121	and	and	CCONJ
admet-1845	54	122	neomycin	neomycin	PROPN
admet-1845	54	123	,	,	PUNCT
admet-1845	54	124	sigma	sigma	PROPN
admet-1845	54	125	-	-	PUNCT
admet-1845	54	126	aldrich	aldrich	PROPN
admet-1845	54	127	,	,	PUNCT
admet-1845	54	128	usa	usa	PROPN
admet-1845	54	129	)	)	PUNCT
admet-1845	54	130	were	be	AUX
admet-1845	54	131	purchased	purchase	VERB
admet-1845	54	132	.	.	PUNCT
admet-1845	55	1	preparation	preparation	NOUN
admet-1845	55	2	and	and	CCONJ
admet-1845	55	3	characterization	characterization	NOUN
admet-1845	55	4	of	of	ADP
admet-1845	55	5	rnpn	rnpn	PROPN
admet-1845	55	6	and	and	CCONJ
admet-1845	55	7	sirnp	sirnp	PROPN
admet-1845	55	8	rnpn	rnpn	PROPN
admet-1845	55	9	was	be	AUX
admet-1845	55	10	prepared	prepare	VERB
admet-1845	55	11	by	by	ADP
admet-1845	55	12	self	self	NOUN
admet-1845	55	13	-	-	PUNCT
admet-1845	55	14	assembly	assembly	NOUN
admet-1845	55	15	amphiphilic	amphiphilic	ADJ
admet-1845	55	16	copolymers	copolymer	NOUN
admet-1845	55	17	peg	peg	NOUN
admet-1845	55	18	-	-	PUNCT
admet-1845	55	19	b	b	NOUN
admet-1845	55	20	-	-	PUNCT
admet-1845	55	21	pmnt	pmnt	NOUN
admet-1845	55	22	,	,	PUNCT
admet-1845	55	23	as	as	SCONJ
admet-1845	55	24	reported	report	VERB
admet-1845	55	25	in	in	ADP
admet-1845	55	26	previous	previous	ADJ
admet-1845	55	27	research	research	NOUN
admet-1845	55	28	[	[	X
admet-1845	55	29	18	18	NUM
admet-1845	55	30	]	]	PUNCT
admet-1845	55	31	.	.	PUNCT
admet-1845	56	1	briefly	briefly	NOUN
admet-1845	56	2	,	,	PUNCT
admet-1845	56	3	15	15	NUM
admet-1845	56	4	mg	mg	NOUN
admet-1845	56	5	of	of	ADP
admet-1845	56	6	peg	peg	NOUN
admet-1845	56	7	-	-	PUNCT
admet-1845	56	8	b	b	NOUN
admet-1845	56	9	-	-	PUNCT
admet-1845	56	10	pmnt	pmnt	NOUN
admet-1845	56	11	were	be	AUX
admet-1845	56	12	dissolved	dissolve	VERB
admet-1845	56	13	in	in	ADP
admet-1845	56	14	1	1	NUM
admet-1845	56	15	ml	ml	NOUN
admet-1845	56	16	of	of	ADP
admet-1845	56	17	dmf	dmf	PROPN
admet-1845	56	18	and	and	CCONJ
admet-1845	56	19	then	then	ADV
admet-1845	56	20	stirred	stir	VERB
admet-1845	56	21	on	on	ADP
admet-1845	56	22	a	a	DET
admet-1845	56	23	magnetic	magnetic	ADJ
admet-1845	56	24	stirrer	stirrer	NOUN
admet-1845	56	25	.	.	PUNCT
admet-1845	57	1	the	the	DET
admet-1845	57	2	mixture	mixture	NOUN
admet-1845	57	3	was	be	AUX
admet-1845	57	4	then	then	ADV
admet-1845	57	5	put	put	VERB
admet-1845	57	6	into	into	ADP
admet-1845	57	7	a	a	DET
admet-1845	57	8	semi	semi	ADJ
admet-1845	57	9	-	-	ADJ
admet-1845	57	10	permeable	permeable	ADJ
admet-1845	57	11	membrane	membrane	NOUN
admet-1845	57	12	tube	tube	NOUN
admet-1845	57	13	before	before	ADP
admet-1845	57	14	being	be	AUX
admet-1845	57	15	dialyzed	dialyze	VERB
admet-1845	57	16	against	against	ADP
admet-1845	57	17	distilled	distil	VERB
admet-1845	57	18	water	water	NOUN
admet-1845	57	19	for	for	ADP
admet-1845	57	20	24	24	NUM
admet-1845	57	21	h.	h.	PROPN
admet-1845	57	22	to	to	PART
admet-1845	57	23	prepare	prepare	VERB
admet-1845	57	24	sirnp	sirnp	PROPN
admet-1845	57	25	,	,	PUNCT
admet-1845	57	26	a	a	DET
admet-1845	57	27	similar	similar	ADJ
admet-1845	57	28	method	method	NOUN
admet-1845	57	29	was	be	AUX
admet-1845	57	30	conducted	conduct	VERB
admet-1845	57	31	,	,	PUNCT
admet-1845	57	32	except	except	SCONJ
admet-1845	57	33	that	that	SCONJ
admet-1845	57	34	50	50	NUM
admet-1845	57	35	µl	µl	NOUN
admet-1845	57	36	of	of	ADP
admet-1845	57	37	teos	teo	NOUN
admet-1845	57	38	and	and	CCONJ
admet-1845	57	39	50	50	NUM
admet-1845	57	40	µl	µl	NOUN
admet-1845	57	41	of	of	ADP
admet-1845	57	42	nh3	nh3	NOUN
admet-1845	57	43	were	be	AUX
admet-1845	57	44	added	add	VERB
admet-1845	57	45	during	during	ADP
admet-1845	57	46	the	the	DET
admet-1845	57	47	stirring	stirring	NOUN
admet-1845	57	48	process	process	NOUN
admet-1845	57	49	(	(	PUNCT
admet-1845	57	50	figure	figure	NOUN
admet-1845	57	51	1	1	NUM
admet-1845	57	52	)	)	PUNCT
admet-1845	57	53	.	.	PUNCT
admet-1845	58	1	the	the	DET
admet-1845	58	2	average	average	ADJ
admet-1845	58	3	size	size	NOUN
admet-1845	58	4	,	,	PUNCT
admet-1845	58	5	polydispersity	polydispersity	NOUN
admet-1845	58	6	index	index	NOUN
admet-1845	58	7	(	(	PUNCT
admet-1845	58	8	pdi	pdi	PROPN
admet-1845	58	9	)	)	PUNCT
admet-1845	58	10	,	,	PUNCT
admet-1845	58	11	and	and	CCONJ
admet-1845	58	12	size	size	NOUN
admet-1845	58	13	distribution	distribution	NOUN
admet-1845	58	14	of	of	ADP
admet-1845	58	15	rnpn	rnpn	NOUN
admet-1845	58	16	and	and	CCONJ
admet-1845	58	17	sirnp	sirnp	PROPN
admet-1845	58	18	were	be	AUX
admet-1845	58	19	then	then	ADV
admet-1845	58	20	characterized	characterize	VERB
admet-1845	58	21	by	by	ADP
admet-1845	58	22	the	the	DET
admet-1845	58	23	dynamic	dynamic	ADJ
admet-1845	58	24	light	light	NOUN
admet-1845	58	25	scattering	scattering	NOUN
admet-1845	58	26	(	(	PUNCT
admet-1845	58	27	dls	dls	PROPN
admet-1845	58	28	,	,	PUNCT
admet-1845	58	29	malvern	malvern	PROPN
admet-1845	58	30	zetasizer	zetasizer	NOUN
admet-1845	58	31	,	,	PUNCT
admet-1845	58	32	uk	uk	PROPN
admet-1845	58	33	)	)	PUNCT
admet-1845	58	34	system	system	NOUN
admet-1845	58	35	.	.	PUNCT
admet-1845	59	1	figure	figure	NOUN
admet-1845	59	2	1	1	NUM
admet-1845	59	3	.	.	PUNCT
admet-1845	60	1	illustration	illustration	NOUN
admet-1845	60	2	of	of	ADP
admet-1845	60	3	dox@rnpn	dox@rnpn	NOUN
admet-1845	60	4	and	and	CCONJ
admet-1845	60	5	dox@sirnp	dox@sirnp	PROPN
admet-1845	60	6	preparation	preparation	NOUN
admet-1845	60	7	.	.	PUNCT
admet-1845	61	1	dox@rnpn	dox@rnpn	PROPN
admet-1845	61	2	was	be	AUX
admet-1845	61	3	prepared	prepare	VERB
admet-1845	61	4	by	by	ADP
admet-1845	61	5	co	co	VERB
admet-1845	61	6	-	-	ADJ
admet-1845	61	7	dissolving	dissolve	VERB
admet-1845	61	8	amphiphilic	amphiphilic	ADJ
admet-1845	61	9	copolymers	copolymer	NOUN
admet-1845	61	10	peg	peg	NOUN
admet-1845	61	11	-	-	PUNCT
admet-1845	61	12	b	b	NOUN
admet-1845	61	13	-	-	PUNCT
admet-1845	61	14	pmnt	pmnt	NOUN
admet-1845	61	15	and	and	CCONJ
admet-1845	61	16	dox	dox	NOUN
admet-1845	61	17	while	while	SCONJ
admet-1845	61	18	dox@sirnp	dox@sirnp	PROPN
admet-1845	61	19	was	be	AUX
admet-1845	61	20	similarly	similarly	ADV
admet-1845	61	21	prepared	prepare	VERB
admet-1845	61	22	,	,	PUNCT
admet-1845	61	23	except	except	SCONJ
admet-1845	61	24	teos	teo	NOUN
admet-1845	61	25	was	be	AUX
admet-1845	61	26	added	add	VERB
admet-1845	61	27	to	to	PART
admet-1845	61	28	form	form	VERB
admet-1845	61	29	silica	silica	NOUN
admet-1845	61	30	nps	nps	PROPN
admet-1845	61	31	under	under	ADP
admet-1845	61	32	the	the	DET
admet-1845	61	33	catalyst	catalyst	NOUN
admet-1845	61	34	of	of	ADP
admet-1845	61	35	nh3	nh3	NOUN
admet-1845	61	36	during	during	ADP
admet-1845	61	37	the	the	DET
admet-1845	61	38	stirring	stirring	NOUN
admet-1845	61	39	process	process	NOUN
admet-1845	61	40	.	.	PUNCT
admet-1845	62	1	the	the	DET
admet-1845	62	2	stability	stability	NOUN
admet-1845	62	3	of	of	ADP
admet-1845	62	4	rnpn	rnpn	PROPN
admet-1845	62	5	and	and	CCONJ
admet-1845	62	6	sirnp	sirnp	PROPN
admet-1845	62	7	phosphate	phosphate	NOUN
admet-1845	62	8	-	-	PUNCT
admet-1845	62	9	buffered	buffer	VERB
admet-1845	62	10	saline	saline	NOUN
admet-1845	62	11	(	(	PUNCT
admet-1845	62	12	pbs	pbs	PROPN
admet-1845	62	13	,	,	PUNCT
admet-1845	62	14	10	10	NUM
admet-1845	62	15	mm	mm	NOUN
admet-1845	62	16	)	)	PUNCT
admet-1845	62	17	was	be	AUX
admet-1845	62	18	prepared	prepare	VERB
admet-1845	62	19	at	at	ADP
admet-1845	62	20	different	different	ADJ
admet-1845	62	21	phs	phs	NOUN
admet-1845	62	22	,	,	PUNCT
admet-1845	62	23	including	include	VERB
admet-1845	62	24	3.0	3.0	NUM
admet-1845	62	25	,	,	PUNCT
admet-1845	62	26	6.5	6.5	NUM
admet-1845	62	27	,	,	PUNCT
admet-1845	62	28	and	and	CCONJ
admet-1845	62	29	7.4	7.4	NUM
admet-1845	62	30	,	,	PUNCT
admet-1845	62	31	to	to	PART
admet-1845	62	32	mimic	mimic	VERB
admet-1845	62	33	the	the	DET
admet-1845	62	34	ph	ph	ADJ
admet-1845	62	35	levels	level	NOUN
admet-1845	62	36	of	of	ADP
admet-1845	62	37	the	the	DET
admet-1845	62	38	gastric	gastric	NOUN
admet-1845	62	39	,	,	PUNCT
admet-1845	62	40	tumour	tumour	NOUN
admet-1845	62	41	extracellular	extracellular	ADJ
admet-1845	62	42	,	,	PUNCT
admet-1845	62	43	and	and	CCONJ
admet-1845	62	44	physiological	physiological	ADJ
admet-1845	62	45	environments	environment	NOUN
admet-1845	62	46	,	,	PUNCT
admet-1845	62	47	respectively	respectively	ADV
admet-1845	62	48	.	.	PUNCT
admet-1845	63	1	rnpn	rnpn	VERB
admet-1845	63	2	https://doi.org/10.5599/admet.1845	https://doi.org/10.5599/admet.1845	NOUN
admet-1845	63	3	m.-d	m.-d	PROPN
admet-1845	63	4	.	.	PUNCT
admet-1845	64	1	quoc	quoc	PROPN
admet-1845	64	2	tang	tang	INTJ
admet-1845	64	3	et	et	PROPN
admet-1845	64	4	al	al	PROPN
admet-1845	64	5	.	.	PROPN
admet-1845	64	6	admet	admet	PROPN
admet-1845	64	7	&	&	CCONJ
admet-1845	64	8	dmpk	dmpk	PROPN
admet-1845	64	9	11(4	11(4	NUM
admet-1845	64	10	)	)	PUNCT
admet-1845	64	11	(	(	PUNCT
admet-1845	64	12	2023	2023	NUM
admet-1845	64	13	)	)	PUNCT
admet-1845	64	14	551	551	NUM
admet-1845	64	15	-	-	SYM
admet-1845	64	16	560	560	NUM
admet-1845	64	17	554	554	NUM
admet-1845	64	18	and	and	CCONJ
admet-1845	64	19	sirnp	sirnp	PROPN
admet-1845	64	20	were	be	AUX
admet-1845	64	21	then	then	ADV
admet-1845	64	22	diluted	dilute	VERB
admet-1845	64	23	in	in	ADP
admet-1845	64	24	the	the	DET
admet-1845	64	25	prepared	prepared	ADJ
admet-1845	64	26	buffers	buffer	NOUN
admet-1845	64	27	.	.	PUNCT
admet-1845	65	1	the	the	DET
admet-1845	65	2	stability	stability	NOUN
admet-1845	65	3	of	of	ADP
admet-1845	65	4	rnp	rnp	PROPN
admet-1845	65	5	n	n	PROPN
admet-1845	65	6	and	and	CCONJ
admet-1845	65	7	sirnp	sirnp	PROPN
admet-1845	65	8	was	be	AUX
admet-1845	65	9	evaluated	evaluate	VERB
admet-1845	65	10	by	by	ADP
admet-1845	65	11	measuring	measure	VERB
admet-1845	65	12	the	the	DET
admet-1845	65	13	change	change	NOUN
admet-1845	65	14	in	in	ADP
admet-1845	65	15	light	light	ADJ
admet-1845	65	16	scattering	scatter	VERB
admet-1845	65	17	intensity	intensity	NOUN
admet-1845	65	18	using	use	VERB
admet-1845	65	19	the	the	DET
admet-1845	65	20	dls	dls	PROPN
admet-1845	65	21	system	system	NOUN
admet-1845	65	22	at	at	ADP
admet-1845	65	23	25	25	NUM
admet-1845	65	24	°	°	NOUN
admet-1845	65	25	c	c	NOUN
admet-1845	65	26	for	for	ADP
admet-1845	65	27	2	2	NUM
admet-1845	65	28	h.	h.	NOUN
admet-1845	65	29	preparation	preparation	NOUN
admet-1845	65	30	and	and	CCONJ
admet-1845	65	31	characterization	characterization	NOUN
admet-1845	65	32	of	of	ADP
admet-1845	65	33	dox@rnpn	dox@rnpn	NOUN
admet-1845	65	34	and	and	CCONJ
admet-1845	65	35	dox@sirnp	dox@sirnp	PROPN
admet-1845	65	36	dox@rnpn	dox@rnpn	PROPN
admet-1845	65	37	and	and	CCONJ
admet-1845	65	38	dox@sirnp	dox@sirnp	PROPN
admet-1845	65	39	were	be	AUX
admet-1845	65	40	prepared	prepare	VERB
admet-1845	65	41	by	by	ADP
admet-1845	65	42	co	co	VERB
admet-1845	65	43	-	-	ADJ
admet-1845	65	44	dissolving	dissolve	VERB
admet-1845	65	45	1	1	NUM
admet-1845	65	46	mg	mg	NOUN
admet-1845	65	47	of	of	ADP
admet-1845	65	48	dox	dox	NOUN
admet-1845	65	49	and	and	CCONJ
admet-1845	65	50	15	15	NUM
admet-1845	65	51	mg	mg	NOUN
admet-1845	65	52	of	of	ADP
admet-1845	65	53	peg	peg	NOUN
admet-1845	65	54	-	-	PUNCT
admet-1845	65	55	b	b	NOUN
admet-1845	65	56	-	-	PUNCT
admet-1845	65	57	pmnt	pmnt	NOUN
admet-1845	65	58	in	in	ADP
admet-1845	65	59	1	1	NUM
admet-1845	65	60	ml	ml	X
admet-1845	65	61	of	of	ADP
admet-1845	65	62	dmf	dmf	PROPN
admet-1845	65	63	.	.	PROPN
admet-1845	66	1	similar	similar	ADJ
admet-1845	66	2	steps	step	NOUN
admet-1845	66	3	were	be	AUX
admet-1845	66	4	followed	follow	VERB
admet-1845	66	5	in	in	ADP
admet-1845	66	6	the	the	DET
admet-1845	66	7	preparation	preparation	NOUN
admet-1845	66	8	of	of	ADP
admet-1845	66	9	rnpn	rnpn	PROPN
admet-1845	66	10	and	and	CCONJ
admet-1845	66	11	sirnp	sirnp	PROPN
admet-1845	66	12	,	,	PUNCT
admet-1845	66	13	respectively	respectively	ADV
admet-1845	66	14	(	(	PUNCT
admet-1845	66	15	figure	figure	NOUN
admet-1845	66	16	1	1	NUM
admet-1845	66	17	)	)	PUNCT
admet-1845	66	18	.	.	PUNCT
admet-1845	67	1	additionally	additionally	ADV
admet-1845	67	2	,	,	PUNCT
admet-1845	67	3	various	various	ADJ
admet-1845	67	4	ratios	ratio	NOUN
admet-1845	67	5	of	of	ADP
admet-1845	67	6	teos	teo	NOUN
admet-1845	67	7	:	:	PUNCT
admet-1845	67	8	nh3	nh3	NUM
admet-1845	67	9	(	(	PUNCT
admet-1845	67	10	200	200	NUM
admet-1845	67	11	μl	μl	PRON
admet-1845	67	12	teos	teo	NOUN
admet-1845	67	13	:	:	PUNCT
admet-1845	67	14	200	200	NUM
admet-1845	67	15	μl	μl	ADP
admet-1845	67	16	nh3	nh3	NOUN
admet-1845	67	17	,	,	PUNCT
admet-1845	67	18	100	100	NUM
admet-1845	67	19	μl	μl	ADP
admet-1845	67	20	teos	teo	NOUN
admet-1845	67	21	:	:	PUNCT
admet-1845	67	22	100	100	NUM
admet-1845	67	23	μl	μl	ADP
admet-1845	67	24	nh3	nh3	NOUN
admet-1845	67	25	,	,	PUNCT
admet-1845	67	26	50	50	NUM
admet-1845	67	27	μl	μl	ADP
admet-1845	67	28	teos	teo	NOUN
admet-1845	67	29	:	:	PUNCT
admet-1845	67	30	50	50	NUM
admet-1845	67	31	μl	μl	ADP
admet-1845	67	32	nh3	nh3	NOUN
admet-1845	67	33	,	,	PUNCT
admet-1845	67	34	100	100	NUM
admet-1845	67	35	μl	μl	ADP
admet-1845	67	36	teos	teo	NOUN
admet-1845	67	37	:	:	PUNCT
admet-1845	67	38	50	50	NUM
admet-1845	67	39	μl	μl	ADP
admet-1845	67	40	nh3	nh3	NOUN
admet-1845	67	41	,	,	PUNCT
admet-1845	67	42	200	200	NUM
admet-1845	67	43	μl	μl	ADP
admet-1845	67	44	teos	teo	NOUN
admet-1845	67	45	:	:	PUNCT
admet-1845	67	46	50	50	NUM
admet-1845	67	47	μl	μl	PRON
admet-1845	67	48	nh3	nh3	NOUN
admet-1845	67	49	)	)	PUNCT
admet-1845	67	50	were	be	AUX
admet-1845	67	51	examined	examine	VERB
admet-1845	67	52	to	to	PART
admet-1845	67	53	optimize	optimize	VERB
admet-1845	67	54	the	the	DET
admet-1845	67	55	size	size	NOUN
admet-1845	67	56	of	of	ADP
admet-1845	67	57	dox@sirnp	dox@sirnp	PROPN
admet-1845	67	58	.	.	PUNCT
admet-1845	68	1	the	the	DET
admet-1845	68	2	dls	dls	PROPN
admet-1845	68	3	system	system	NOUN
admet-1845	68	4	was	be	AUX
admet-1845	68	5	used	use	VERB
admet-1845	68	6	to	to	PART
admet-1845	68	7	characterize	characterize	VERB
admet-1845	68	8	the	the	DET
admet-1845	68	9	average	average	ADJ
admet-1845	68	10	size	size	NOUN
admet-1845	68	11	,	,	PUNCT
admet-1845	68	12	pdi	pdi	NOUN
admet-1845	68	13	,	,	PUNCT
admet-1845	68	14	and	and	CCONJ
admet-1845	68	15	size	size	NOUN
admet-1845	68	16	distribution	distribution	NOUN
admet-1845	68	17	of	of	ADP
admet-1845	68	18	dox@rnp	dox@rnp	PROPN
admet-1845	68	19	n	n	PROPN
admet-1845	68	20	and	and	CCONJ
admet-1845	68	21	dox@sirnp	dox@sirnp	PROPN
admet-1845	68	22	.	.	PUNCT
admet-1845	69	1	drug	drug	NOUN
admet-1845	69	2	encapsulated	encapsulate	VERB
admet-1845	69	3	efficiency	efficiency	NOUN
admet-1845	69	4	and	and	CCONJ
admet-1845	69	5	loading	loading	NOUN
admet-1845	69	6	capacity	capacity	NOUN
admet-1845	69	7	of	of	ADP
admet-1845	69	8	dox@rnpn	dox@rnpn	NOUN
admet-1845	69	9	and	and	CCONJ
admet-1845	69	10	dox@sirnp	dox@sirnp	VERB
admet-1845	69	11	the	the	DET
admet-1845	69	12	encapsulation	encapsulation	NOUN
admet-1845	69	13	efficiency	efficiency	NOUN
admet-1845	69	14	(	(	PUNCT
admet-1845	69	15	ee	ee	PROPN
admet-1845	69	16	/	/	SYM
admet-1845	69	17	%	%	NOUN
admet-1845	69	18	)	)	PUNCT
admet-1845	69	19	and	and	CCONJ
admet-1845	69	20	loading	loading	NOUN
admet-1845	69	21	capacity	capacity	NOUN
admet-1845	69	22	(	(	PUNCT
admet-1845	69	23	lc	lc	PROPN
admet-1845	69	24	/	/	SYM
admet-1845	69	25	%	%	NOUN
admet-1845	69	26	)	)	PUNCT
admet-1845	69	27	of	of	ADP
admet-1845	69	28	dox@rnpn	dox@rnpn	NOUN
admet-1845	69	29	and	and	CCONJ
admet-1845	69	30	dox@sirnp	dox@sirnp	PROPN
admet-1845	69	31	were	be	AUX
admet-1845	69	32	investigated	investigate	VERB
admet-1845	69	33	based	base	VERB
admet-1845	69	34	on	on	ADP
admet-1845	69	35	the	the	DET
admet-1845	69	36	amount	amount	NOUN
admet-1845	69	37	of	of	ADP
admet-1845	69	38	loaded	loaded	ADJ
admet-1845	69	39	dox	dox	NOUN
admet-1845	69	40	evaluated	evaluate	VERB
admet-1845	69	41	by	by	ADP
admet-1845	69	42	a	a	DET
admet-1845	69	43	microplate	microplate	NOUN
admet-1845	69	44	reader	reader	NOUN
admet-1845	69	45	(	(	PUNCT
admet-1845	69	46	thermo	thermo	NOUN
admet-1845	69	47	fisher	fisher	PROPN
admet-1845	69	48	scientific	scientific	PROPN
admet-1845	69	49	,	,	PUNCT
admet-1845	69	50	usa	usa	PROPN
admet-1845	69	51	)	)	PUNCT
admet-1845	69	52	with	with	ADP
admet-1845	69	53	a	a	DET
admet-1845	69	54	calibration	calibration	NOUN
admet-1845	69	55	curve	curve	NOUN
admet-1845	69	56	of	of	ADP
admet-1845	69	57	dox	dox	NOUN
admet-1845	69	58	measured	measure	VERB
admet-1845	69	59	absorbance	absorbance	NOUN
admet-1845	69	60	at	at	ADP
admet-1845	69	61	480	480	NUM
admet-1845	69	62	nm	nm	NOUN
admet-1845	69	63	.	.	PUNCT
admet-1845	70	1	the	the	DET
admet-1845	70	2	ee	ee	PROPN
admet-1845	70	3	and	and	CCONJ
admet-1845	70	4	lc	lc	PROPN
admet-1845	70	5	were	be	AUX
admet-1845	70	6	calculated	calculate	VERB
admet-1845	70	7	by	by	ADP
admet-1845	70	8	using	use	VERB
admet-1845	70	9	equation	equation	NOUN
admet-1845	70	10	(	(	PUNCT
admet-1845	70	11	1	1	NUM
admet-1845	70	12	)	)	PUNCT
admet-1845	70	13	and	and	CCONJ
admet-1845	70	14	(	(	PUNCT
admet-1845	70	15	2	2	NUM
admet-1845	70	16	):	):	PUNCT
admet-1845	70	17	encaplulated	encaplulated	ADJ
admet-1845	70	18	theoretical	theoretical	ADJ
admet-1845	70	19	dox	dox	NOUN
admet-1845	70	20	total	total	NOUN
admet-1845	70	21	mass	mass	PROPN
admet-1845	70	22	100	100	NUM
admet-1845	70	23	total	total	ADJ
admet-1845	70	24	mass	mass	NOUN
admet-1845	70	25	ee	ee	PROPN
admet-1845	70	26	=	=	SYM
admet-1845	70	27	(	(	PUNCT
admet-1845	70	28	1	1	X
admet-1845	70	29	)	)	PUNCT
admet-1845	70	30	encaplulated	encaplulated	ADJ
admet-1845	70	31	dox	dox	NOUN
admet-1845	70	32	theoretical	theoretical	ADJ
admet-1845	70	33	polymers	polymer	NOUN
admet-1845	70	34	total	total	VERB
admet-1845	70	35	mass	mass	PROPN
admet-1845	70	36	100	100	NUM
admet-1845	70	37	total	total	ADJ
admet-1845	70	38	mass	mass	NOUN
admet-1845	70	39	lc	lc	PROPN
admet-1845	70	40	=	=	SYM
admet-1845	70	41	(	(	PUNCT
admet-1845	70	42	2	2	NUM
admet-1845	70	43	)	)	PUNCT
admet-1845	70	44	release	release	NOUN
admet-1845	70	45	profile	profile	NOUN
admet-1845	70	46	of	of	ADP
admet-1845	70	47	dox@rnpn	dox@rnpn	NOUN
admet-1845	70	48	and	and	CCONJ
admet-1845	70	49	dox@sirnp	dox@sirnp	PROPN
admet-1845	70	50	2	2	NUM
admet-1845	70	51	ml	ml	NOUN
admet-1845	70	52	of	of	ADP
admet-1845	70	53	dox@rnpn	dox@rnpn	NOUN
admet-1845	70	54	or	or	CCONJ
admet-1845	70	55	dox@sirnp	dox@sirnp	PROPN
admet-1845	70	56	were	be	AUX
admet-1845	70	57	loaded	load	VERB
admet-1845	70	58	into	into	ADP
admet-1845	70	59	separate	separate	ADJ
admet-1845	70	60	dialysis	dialysis	NOUN
admet-1845	70	61	bags	bag	NOUN
admet-1845	70	62	and	and	CCONJ
admet-1845	70	63	placed	place	VERB
admet-1845	70	64	in	in	ADP
admet-1845	70	65	different	different	ADJ
admet-1845	70	66	beakers	beaker	NOUN
admet-1845	70	67	under	under	ADP
admet-1845	70	68	stirring	stir	VERB
admet-1845	70	69	conditions	condition	NOUN
admet-1845	70	70	,	,	PUNCT
admet-1845	70	71	each	each	PRON
admet-1845	70	72	with	with	ADP
admet-1845	70	73	distinct	distinct	ADJ
admet-1845	70	74	ph	ph	NOUN
admet-1845	70	75	including	include	VERB
admet-1845	70	76	3	3	NUM
admet-1845	70	77	,	,	PUNCT
admet-1845	70	78	6.5	6.5	NUM
admet-1845	70	79	,	,	PUNCT
admet-1845	70	80	and	and	CCONJ
admet-1845	70	81	7.4	7.4	NUM
admet-1845	70	82	.	.	PUNCT
admet-1845	71	1	at	at	ADP
admet-1845	71	2	predetermined	predetermine	VERB
admet-1845	71	3	time	time	NOUN
admet-1845	71	4	points	point	NOUN
admet-1845	71	5	(	(	PUNCT
admet-1845	71	6	0	0	NUM
admet-1845	71	7	,	,	PUNCT
admet-1845	71	8	1	1	NUM
admet-1845	71	9	,	,	PUNCT
admet-1845	71	10	3	3	NUM
admet-1845	71	11	,	,	PUNCT
admet-1845	71	12	6	6	NUM
admet-1845	71	13	,	,	PUNCT
admet-1845	71	14	9	9	NUM
admet-1845	71	15	,	,	PUNCT
admet-1845	71	16	20	20	NUM
admet-1845	71	17	,	,	PUNCT
admet-1845	71	18	and	and	CCONJ
admet-1845	71	19	24	24	NUM
admet-1845	71	20	h	h	NOUN
admet-1845	71	21	)	)	PUNCT
admet-1845	71	22	,	,	PUNCT
admet-1845	71	23	samples	sample	NOUN
admet-1845	71	24	were	be	AUX
admet-1845	71	25	collected	collect	VERB
admet-1845	71	26	and	and	CCONJ
admet-1845	71	27	the	the	DET
admet-1845	71	28	absorbance	absorbance	NOUN
admet-1845	71	29	at	at	ADP
admet-1845	71	30	480	480	NUM
admet-1845	71	31	nm	nm	NOUN
admet-1845	71	32	was	be	AUX
admet-1845	71	33	measured	measure	VERB
admet-1845	71	34	to	to	PART
admet-1845	71	35	evaluate	evaluate	VERB
admet-1845	71	36	the	the	DET
admet-1845	71	37	amount	amount	NOUN
admet-1845	71	38	of	of	ADP
admet-1845	71	39	drug	drug	NOUN
admet-1845	71	40	released	release	VERB
admet-1845	71	41	from	from	ADP
admet-1845	71	42	the	the	DET
admet-1845	71	43	nps	nps	PROPN
admet-1845	71	44	.	.	PUNCT
admet-1845	72	1	cytotoxic	cytotoxic	PROPN
admet-1845	72	2	assay	assay	VERB
admet-1845	72	3	the	the	DET
admet-1845	72	4	murine	murine	ADJ
admet-1845	72	5	fibroblast	fibroblast	ADJ
admet-1845	72	6	cells	cell	NOUN
admet-1845	72	7	(	(	PUNCT
admet-1845	72	8	l929	l929	PROPN
admet-1845	72	9	)	)	PUNCT
admet-1845	72	10	,	,	PUNCT
admet-1845	72	11	human	human	ADJ
admet-1845	72	12	breast	breast	NOUN
admet-1845	72	13	cancer	cancer	NOUN
admet-1845	72	14	cells	cell	NOUN
admet-1845	72	15	(	(	PUNCT
admet-1845	72	16	mcf-7	mcf-7	NOUN
admet-1845	72	17	)	)	PUNCT
admet-1845	72	18	,	,	PUNCT
admet-1845	72	19	and	and	CCONJ
admet-1845	72	20	human	human	ADJ
admet-1845	72	21	hepatocellular	hepatocellular	ADJ
admet-1845	72	22	carcinoma	carcinoma	NOUN
admet-1845	72	23	cells	cell	NOUN
admet-1845	72	24	(	(	PUNCT
admet-1845	72	25	hepg2	hepg2	NOUN
admet-1845	72	26	)	)	PUNCT
admet-1845	72	27	were	be	AUX
admet-1845	72	28	obtained	obtain	VERB
admet-1845	72	29	from	from	ADP
admet-1845	72	30	the	the	DET
admet-1845	72	31	american	american	ADJ
admet-1845	72	32	type	type	NOUN
admet-1845	72	33	culture	culture	NOUN
admet-1845	72	34	collection	collection	NOUN
admet-1845	72	35	(	(	PUNCT
admet-1845	72	36	atcc	atcc	NOUN
admet-1845	72	37	,	,	PUNCT
admet-1845	72	38	usa	usa	PROPN
admet-1845	72	39	)	)	PUNCT
admet-1845	72	40	.	.	PUNCT
admet-1845	73	1	the	the	DET
admet-1845	73	2	cells	cell	NOUN
admet-1845	73	3	were	be	AUX
admet-1845	73	4	cultured	cultured	ADJ
admet-1845	73	5	in	in	ADP
admet-1845	73	6	dmem	dmem	ADJ
admet-1845	73	7	containing	contain	VERB
admet-1845	73	8	10	10	NUM
admet-1845	73	9	%	%	NOUN
admet-1845	73	10	fbs	fbs	ADJ
admet-1845	73	11	and	and	CCONJ
admet-1845	73	12	1	1	NUM
admet-1845	73	13	%	%	NOUN
admet-1845	73	14	antibiotics	antibiotic	NOUN
admet-1845	73	15	(	(	PUNCT
admet-1845	73	16	a	a	DET
admet-1845	73	17	mixture	mixture	NOUN
admet-1845	73	18	of	of	ADP
admet-1845	73	19	penicillin	penicillin	NOUN
admet-1845	73	20	,	,	PUNCT
admet-1845	73	21	streptomycin	streptomycin	PROPN
admet-1845	73	22	,	,	PUNCT
admet-1845	73	23	and	and	CCONJ
admet-1845	73	24	neomycin	neomycin	NOUN
admet-1845	73	25	)	)	PUNCT
admet-1845	73	26	at	at	ADP
admet-1845	73	27	37	37	NUM
admet-1845	73	28	°	°	NOUN
admet-1845	73	29	c	c	NOUN
admet-1845	73	30	and	and	CCONJ
admet-1845	73	31	5	5	NUM
admet-1845	73	32	%	%	NOUN
admet-1845	73	33	co2	co2	NOUN
admet-1845	73	34	.	.	PUNCT
admet-1845	74	1	the	the	DET
admet-1845	74	2	cells	cell	NOUN
admet-1845	74	3	were	be	AUX
admet-1845	74	4	then	then	ADV
admet-1845	74	5	seeded	seed	VERB
admet-1845	74	6	on	on	ADP
admet-1845	74	7	96	96	NUM
admet-1845	74	8	-	-	PUNCT
admet-1845	74	9	well	well	NOUN
admet-1845	74	10	plates	plate	NOUN
admet-1845	74	11	(	(	PUNCT
admet-1845	74	12	104	104	NUM
admet-1845	74	13	cells	cell	NOUN
admet-1845	74	14	/	/	SYM
admet-1845	74	15	well	well	ADV
admet-1845	74	16	)	)	PUNCT
admet-1845	74	17	and	and	CCONJ
admet-1845	74	18	incubated	incubate	VERB
admet-1845	74	19	for	for	ADP
admet-1845	74	20	24	24	NUM
admet-1845	74	21	h	h	NOUN
admet-1845	74	22	at	at	ADP
admet-1845	74	23	37	37	NUM
admet-1845	74	24	°	°	NOUN
admet-1845	74	25	c	c	NOUN
admet-1845	74	26	and	and	CCONJ
admet-1845	74	27	5	5	NUM
admet-1845	74	28	%	%	NOUN
admet-1845	74	29	co2	co2	NOUN
admet-1845	74	30	.	.	PUNCT
admet-1845	75	1	the	the	DET
admet-1845	75	2	tested	test	VERB
admet-1845	75	3	samples	sample	NOUN
admet-1845	75	4	,	,	PUNCT
admet-1845	75	5	including	include	VERB
admet-1845	75	6	rnpn	rnpn	PROPN
admet-1845	75	7	,	,	PUNCT
admet-1845	75	8	sirnp	sirnp	PROPN
admet-1845	75	9	,	,	PUNCT
admet-1845	75	10	dox	dox	NOUN
admet-1845	75	11	,	,	PUNCT
admet-1845	75	12	dox@rnpn	dox@rnpn	NOUN
admet-1845	75	13	,	,	PUNCT
admet-1845	75	14	and	and	CCONJ
admet-1845	75	15	dox@sirnp	dox@sirnp	PROPN
admet-1845	75	16	,	,	PUNCT
admet-1845	75	17	were	be	AUX
admet-1845	75	18	added	add	VERB
admet-1845	75	19	to	to	ADP
admet-1845	75	20	each	each	DET
admet-1845	75	21	well	well	NOUN
admet-1845	75	22	to	to	PART
admet-1845	75	23	obtain	obtain	VERB
admet-1845	75	24	final	final	ADJ
admet-1845	75	25	concentrations	concentration	NOUN
admet-1845	75	26	of	of	ADP
admet-1845	75	27	dox	dox	NOUN
admet-1845	75	28	at	at	ADP
admet-1845	75	29	0.25	0.25	NUM
admet-1845	75	30	,	,	PUNCT
admet-1845	75	31	0.5	0.5	NUM
admet-1845	75	32	,	,	PUNCT
admet-1845	75	33	1	1	NUM
admet-1845	75	34	,	,	PUNCT
admet-1845	75	35	2.5	2.5	NUM
admet-1845	75	36	,	,	PUNCT
admet-1845	75	37	and	and	CCONJ
admet-1845	75	38	5	5	NUM
admet-1845	75	39	µg	µg	ADV
admet-1845	75	40	/	/	SYM
admet-1845	75	41	ml	ml	NOUN
admet-1845	75	42	,	,	PUNCT
admet-1845	75	43	and	and	CCONJ
admet-1845	75	44	incubated	incubate	VERB
admet-1845	75	45	for	for	ADP
admet-1845	75	46	24	24	NUM
admet-1845	75	47	h.	h.	PROPN
admet-1845	75	48	after	after	ADP
admet-1845	75	49	that	that	PRON
admet-1845	75	50	,	,	PUNCT
admet-1845	75	51	the	the	DET
admet-1845	75	52	medium	medium	NOUN
admet-1845	75	53	was	be	AUX
admet-1845	75	54	removed	remove	VERB
admet-1845	75	55	,	,	PUNCT
admet-1845	75	56	and	and	CCONJ
admet-1845	75	57	mtt	mtt	NOUN
admet-1845	75	58	solution	solution	NOUN
admet-1845	75	59	was	be	AUX
admet-1845	75	60	added	add	VERB
admet-1845	75	61	to	to	ADP
admet-1845	75	62	each	each	DET
admet-1845	75	63	well	well	ADV
admet-1845	75	64	and	and	CCONJ
admet-1845	75	65	continuously	continuously	ADV
admet-1845	75	66	incubated	incubate	VERB
admet-1845	75	67	for	for	ADP
admet-1845	75	68	4	4	NUM
admet-1845	75	69	h.	h.	PROPN
admet-1845	75	70	finally	finally	ADV
admet-1845	75	71	,	,	PUNCT
admet-1845	75	72	dmso	dmso	NOUN
admet-1845	75	73	was	be	AUX
admet-1845	75	74	added	add	VERB
admet-1845	75	75	to	to	PART
admet-1845	75	76	dissolve	dissolve	VERB
admet-1845	75	77	crystals	crystal	NOUN
admet-1845	75	78	of	of	ADP
admet-1845	75	79	formazan	formazan	NOUN
admet-1845	75	80	inside	inside	ADP
admet-1845	75	81	the	the	DET
admet-1845	75	82	cells	cell	NOUN
admet-1845	75	83	,	,	PUNCT
admet-1845	75	84	and	and	CCONJ
admet-1845	75	85	the	the	DET
admet-1845	75	86	plates	plate	NOUN
admet-1845	75	87	were	be	AUX
admet-1845	75	88	measured	measure	VERB
admet-1845	75	89	absorbance	absorbance	NOUN
admet-1845	75	90	at	at	ADP
admet-1845	75	91	540	540	NUM
admet-1845	75	92	nm	nm	NOUN
admet-1845	75	93	by	by	ADP
admet-1845	75	94	a	a	DET
admet-1845	75	95	microplate	microplate	NOUN
admet-1845	75	96	reader	reader	NOUN
admet-1845	75	97	(	(	PUNCT
admet-1845	75	98	thermo	thermo	NOUN
admet-1845	75	99	fisher	fisher	PROPN
admet-1845	75	100	scientific	scientific	PROPN
admet-1845	75	101	,	,	PUNCT
admet-1845	75	102	usa	usa	PROPN
admet-1845	75	103	)	)	PUNCT
admet-1845	75	104	.	.	PUNCT
admet-1845	76	1	the	the	DET
admet-1845	76	2	cell	cell	NOUN
admet-1845	76	3	viability	viability	NOUN
admet-1845	76	4	(	(	PUNCT
admet-1845	76	5	%	%	INTJ
admet-1845	76	6	)	)	PUNCT
admet-1845	76	7	was	be	AUX
admet-1845	76	8	calculated	calculate	VERB
admet-1845	76	9	by	by	ADP
admet-1845	76	10	using	use	VERB
admet-1845	76	11	equation	equation	NOUN
admet-1845	76	12	(	(	PUNCT
admet-1845	76	13	3	3	NUM
admet-1845	76	14	):	):	PUNCT
admet-1845	76	15	sample	sample	NOUN
admet-1845	76	16	control	control	NOUN
admet-1845	76	17	od	od	PROPN
admet-1845	76	18	cell	cell	NOUN
admet-1845	76	19	viability	viability	NOUN
admet-1845	76	20	100	100	NUM
admet-1845	76	21	od	od	NOUN
admet-1845	76	22	=	=	PUNCT
admet-1845	76	23	(	(	PUNCT
admet-1845	76	24	3	3	NUM
admet-1845	76	25	)	)	PUNCT
admet-1845	76	26	where	where	SCONJ
admet-1845	76	27	odsample	odsample	NOUN
admet-1845	76	28	is	be	AUX
admet-1845	76	29	the	the	DET
admet-1845	76	30	absorbance	absorbance	NOUN
admet-1845	76	31	of	of	ADP
admet-1845	76	32	the	the	DET
admet-1845	76	33	sample	sample	NOUN
admet-1845	76	34	and	and	CCONJ
admet-1845	76	35	odcontrol	odcontrol	NOUN
admet-1845	76	36	is	be	AUX
admet-1845	76	37	the	the	DET
admet-1845	76	38	absorbance	absorbance	NOUN
admet-1845	76	39	of	of	ADP
admet-1845	76	40	the	the	DET
admet-1845	76	41	solvent	solvent	NOUN
admet-1845	76	42	.	.	PUNCT
admet-1845	77	1	statistical	statistical	ADJ
admet-1845	77	2	analysis	analysis	NOUN
admet-1845	77	3	statistical	statistical	ADJ
admet-1845	77	4	analysis	analysis	NOUN
admet-1845	77	5	was	be	AUX
admet-1845	77	6	performed	perform	VERB
admet-1845	77	7	using	use	VERB
admet-1845	77	8	one	one	NUM
admet-1845	77	9	-	-	PUNCT
admet-1845	77	10	way	way	NOUN
admet-1845	77	11	analysis	analysis	NOUN
admet-1845	77	12	of	of	ADP
admet-1845	77	13	variance	variance	NOUN
admet-1845	77	14	(	(	PUNCT
admet-1845	77	15	anova	anova	PROPN
admet-1845	77	16	)	)	PUNCT
admet-1845	77	17	to	to	PART
admet-1845	77	18	determine	determine	VERB
admet-1845	77	19	significant	significant	ADJ
admet-1845	77	20	differences	difference	NOUN
admet-1845	77	21	among	among	ADP
admet-1845	77	22	various	various	ADJ
admet-1845	77	23	groups	group	NOUN
admet-1845	77	24	.	.	PUNCT
admet-1845	78	1	a	a	PRON
admet-1845	78	2	p	p	NOUN
admet-1845	78	3	-	-	PUNCT
admet-1845	78	4	value	value	NOUN
admet-1845	78	5	<	<	NOUN
admet-1845	78	6	0.05	0.05	NUM
admet-1845	78	7	was	be	AUX
admet-1845	78	8	considered	consider	VERB
admet-1845	78	9	statistically	statistically	ADV
admet-1845	78	10	significant	significant	ADJ
admet-1845	78	11	.	.	PUNCT
admet-1845	79	1	data	datum	NOUN
admet-1845	79	2	were	be	AUX
admet-1845	79	3	presented	present	VERB
admet-1845	79	4	as	as	ADP
admet-1845	79	5	the	the	DET
admet-1845	79	6	mean	mean	PROPN
admet-1845	79	7	±	±	NUM
admet-1845	79	8	standard	standard	ADJ
admet-1845	79	9	deviation	deviation	NOUN
admet-1845	79	10	(	(	PUNCT
admet-1845	79	11	sd	sd	NOUN
admet-1845	79	12	)	)	PUNCT
admet-1845	79	13	.	.	PUNCT
admet-1845	80	1	admet	admet	PROPN
admet-1845	80	2	&	&	CCONJ
admet-1845	80	3	dmpk	dmpk	PROPN
admet-1845	80	4	11(4	11(4	NUM
admet-1845	80	5	)	)	PUNCT
admet-1845	80	6	(	(	PUNCT
admet-1845	80	7	2023	2023	NUM
admet-1845	80	8	)	)	PUNCT
admet-1845	80	9	551	551	NUM
admet-1845	80	10	-	-	SYM
admet-1845	80	11	560	560	NUM
admet-1845	80	12	drug	drug	NOUN
admet-1845	80	13	encapsulation	encapsulation	NOUN
admet-1845	80	14	and	and	CCONJ
admet-1845	80	15	suppress	suppress	VERB
admet-1845	80	16	the	the	DET
admet-1845	80	17	adverse	adverse	ADJ
admet-1845	80	18	effect	effect	NOUN
admet-1845	80	19	of	of	ADP
admet-1845	80	20	doxorubicin	doxorubicin	PROPN
admet-1845	80	21	doi	doi	PROPN
admet-1845	80	22	:	:	PUNCT
admet-1845	80	23	https://doi.org/10.5599/adme	https://doi.org/10.5599/adme	NOUN
admet-1845	80	24	t.1845	t.1845	NOUN
admet-1845	80	25	555	555	NUM
admet-1845	80	26	results	result	NOUN
admet-1845	80	27	and	and	CCONJ
admet-1845	80	28	discussion	discussion	NOUN
admet-1845	80	29	characterization	characterization	NOUN
admet-1845	80	30	of	of	ADP
admet-1845	80	31	rnpn	rnpn	PROPN
admet-1845	80	32	and	and	CCONJ
admet-1845	80	33	sirnp	sirnp	PROPN
admet-1845	80	34	rnpn	rnpn	PROPN
admet-1845	80	35	and	and	CCONJ
admet-1845	80	36	sirnp	sirnp	PROPN
admet-1845	80	37	were	be	AUX
admet-1845	80	38	prepared	prepare	VERB
admet-1845	80	39	by	by	ADP
admet-1845	80	40	self	self	NOUN
admet-1845	80	41	-	-	PUNCT
admet-1845	80	42	assembly	assembly	NOUN
admet-1845	80	43	amphiphilic	amphiphilic	ADJ
admet-1845	80	44	copolymers	copolymer	NOUN
admet-1845	80	45	peg	peg	NOUN
admet-1845	80	46	-	-	PUNCT
admet-1845	80	47	b	b	NOUN
admet-1845	80	48	-	-	PUNCT
admet-1845	80	49	pmnt	pmnt	NOUN
admet-1845	80	50	in	in	ADP
admet-1845	80	51	dmf	dmf	PROPN
admet-1845	80	52	,	,	PUNCT
admet-1845	80	53	followed	follow	VERB
admet-1845	80	54	by	by	ADP
admet-1845	80	55	dialysis	dialysis	NOUN
admet-1845	80	56	against	against	ADP
admet-1845	80	57	distilled	distil	VERB
admet-1845	80	58	water	water	NOUN
admet-1845	80	59	for	for	ADP
admet-1845	80	60	24	24	NUM
admet-1845	80	61	h	h	NOUN
admet-1845	80	62	to	to	PART
admet-1845	80	63	remove	remove	VERB
admet-1845	80	64	the	the	DET
admet-1845	80	65	organic	organic	ADJ
admet-1845	80	66	solvent	solvent	NOUN
admet-1845	80	67	.	.	PUNCT
admet-1845	81	1	the	the	DET
admet-1845	81	2	results	result	NOUN
admet-1845	81	3	showed	show	VERB
admet-1845	81	4	that	that	SCONJ
admet-1845	81	5	both	both	PRON
admet-1845	81	6	rnpn	rnpn	VERB
admet-1845	81	7	and	and	CCONJ
admet-1845	81	8	sirnp	sirnp	PROPN
admet-1845	81	9	were	be	AUX
admet-1845	81	10	transparent	transparent	ADJ
admet-1845	81	11	(	(	PUNCT
admet-1845	81	12	figure	figure	NOUN
admet-1845	81	13	2a	2a	NUM
admet-1845	81	14	)	)	PUNCT
admet-1845	81	15	,	,	PUNCT
admet-1845	81	16	with	with	ADP
admet-1845	81	17	average	average	ADJ
admet-1845	81	18	sizes	size	NOUN
admet-1845	81	19	of	of	ADP
admet-1845	81	20	45.5	45.5	NUM
admet-1845	81	21	and	and	CCONJ
admet-1845	81	22	85.5	85.5	NUM
admet-1845	81	23	nm	nm	NOUN
admet-1845	81	24	,	,	PUNCT
admet-1845	81	25	respectively	respectively	ADV
admet-1845	81	26	(	(	PUNCT
admet-1845	81	27	figure	figure	NOUN
admet-1845	81	28	2b	2b	NOUN
admet-1845	81	29	)	)	PUNCT
admet-1845	81	30	.	.	PUNCT
admet-1845	82	1	furthermore	furthermore	ADV
admet-1845	82	2	,	,	PUNCT
admet-1845	82	3	the	the	DET
admet-1845	82	4	pdi	pdi	NOUN
admet-1845	82	5	of	of	ADP
admet-1845	82	6	both	both	DET
admet-1845	82	7	nps	nps	PROPN
admet-1845	82	8	was	be	AUX
admet-1845	82	9	less	less	ADJ
admet-1845	82	10	than	than	ADP
admet-1845	82	11	0.3	0.3	NUM
admet-1845	82	12	,	,	PUNCT
admet-1845	82	13	indicating	indicate	VERB
admet-1845	82	14	a	a	DET
admet-1845	82	15	narrow	narrow	ADJ
admet-1845	82	16	size	size	NOUN
admet-1845	82	17	distribution	distribution	NOUN
admet-1845	82	18	.	.	PUNCT
admet-1845	83	1	the	the	DET
admet-1845	83	2	increase	increase	NOUN
admet-1845	83	3	in	in	ADP
admet-1845	83	4	the	the	DET
admet-1845	83	5	size	size	NOUN
admet-1845	83	6	of	of	ADP
admet-1845	83	7	sirnp	sirnp	PROPN
admet-1845	83	8	as	as	SCONJ
admet-1845	83	9	compared	compare	VERB
admet-1845	83	10	to	to	PART
admet-1845	83	11	rnpn	rnpn	VERB
admet-1845	83	12	might	might	AUX
admet-1845	83	13	be	be	AUX
admet-1845	83	14	explained	explain	VERB
admet-1845	83	15	by	by	ADP
admet-1845	83	16	a	a	DET
admet-1845	83	17	sol	sol	NOUN
admet-1845	83	18	-	-	PUNCT
admet-1845	83	19	gel	gel	NOUN
admet-1845	83	20	reaction	reaction	NOUN
admet-1845	83	21	of	of	ADP
admet-1845	83	22	teos	teo	NOUN
admet-1845	83	23	in	in	ADP
admet-1845	83	24	the	the	DET
admet-1845	83	25	rnpn	rnpn	NOUN
admet-1845	83	26	core	core	NOUN
admet-1845	83	27	[	[	X
admet-1845	83	28	22	22	NUM
admet-1845	83	29	]	]	PUNCT
admet-1845	83	30	.	.	PUNCT
admet-1845	84	1	the	the	DET
admet-1845	84	2	size	size	NOUN
admet-1845	84	3	of	of	ADP
admet-1845	84	4	sirnp	sirnp	PROPN
admet-1845	84	5	was	be	AUX
admet-1845	84	6	approximately	approximately	ADV
admet-1845	84	7	85	85	NUM
admet-1845	84	8	nm	nm	NOUN
admet-1845	84	9	after	after	ADP
admet-1845	84	10	the	the	DET
admet-1845	84	11	condensation	condensation	NOUN
admet-1845	84	12	reaction	reaction	NOUN
admet-1845	84	13	,	,	PUNCT
admet-1845	84	14	suggesting	suggest	VERB
admet-1845	84	15	no	no	DET
admet-1845	84	16	significant	significant	ADJ
admet-1845	84	17	aggregation	aggregation	NOUN
admet-1845	84	18	(	(	PUNCT
admet-1845	84	19	figure	figure	NOUN
admet-1845	84	20	2c	2c	NUM
admet-1845	84	21	)	)	PUNCT
admet-1845	84	22	,	,	PUNCT
admet-1845	84	23	even	even	ADV
admet-1845	84	24	though	though	SCONJ
admet-1845	84	25	silica	silica	NOUN
admet-1845	84	26	particles	particle	NOUN
admet-1845	84	27	formed	form	VERB
admet-1845	84	28	by	by	ADP
admet-1845	84	29	sol	sol	NOUN
admet-1845	84	30	-	-	PUNCT
admet-1845	84	31	gel	gel	NOUN
admet-1845	84	32	can	can	AUX
admet-1845	84	33	reach	reach	VERB
admet-1845	84	34	up	up	ADP
admet-1845	84	35	to	to	ADP
admet-1845	84	36	2000	2000	NUM
admet-1845	84	37	nm	nm	NOUN
admet-1845	84	38	.	.	PUNCT
admet-1845	85	1	we	we	PRON
admet-1845	85	2	next	next	ADV
admet-1845	85	3	examined	examine	VERB
admet-1845	85	4	the	the	DET
admet-1845	85	5	influence	influence	NOUN
admet-1845	85	6	of	of	ADP
admet-1845	85	7	different	different	ADJ
admet-1845	85	8	ph	ph	ADJ
admet-1845	85	9	buffers	buffer	NOUN
admet-1845	85	10	on	on	ADP
admet-1845	85	11	the	the	DET
admet-1845	85	12	stability	stability	NOUN
admet-1845	85	13	of	of	ADP
admet-1845	85	14	nps	nps	PROPN
admet-1845	85	15	[	[	X
admet-1845	85	16	23	23	NUM
admet-1845	85	17	]	]	PUNCT
admet-1845	85	18	.	.	PUNCT
admet-1845	86	1	as	as	SCONJ
admet-1845	86	2	shown	show	VERB
admet-1845	86	3	in	in	ADP
admet-1845	86	4	figure	figure	NOUN
admet-1845	86	5	2d	2d	NOUN
admet-1845	86	6	,	,	PUNCT
admet-1845	86	7	rnpn	rnpn	VERB
admet-1845	86	8	disintegrated	disintegrate	VERB
admet-1845	86	9	under	under	ADP
admet-1845	86	10	acidic	acidic	ADJ
admet-1845	86	11	ph	ph	NOUN
admet-1845	86	12	(	(	PUNCT
admet-1845	86	13	3.0	3.0	NUM
admet-1845	86	14	and	and	CCONJ
admet-1845	86	15	6.5	6.5	NUM
admet-1845	86	16	)	)	PUNCT
admet-1845	86	17	and	and	CCONJ
admet-1845	86	18	stabilized	stabilize	VERB
admet-1845	86	19	at	at	ADP
admet-1845	86	20	ph	ph	PROPN
admet-1845	86	21	7.4	7.4	NUM
admet-1845	86	22	.	.	PUNCT
admet-1845	87	1	in	in	ADP
admet-1845	87	2	contrast	contrast	NOUN
admet-1845	87	3	,	,	PUNCT
admet-1845	87	4	sirnp	sirnp	PROPN
admet-1845	87	5	was	be	AUX
admet-1845	87	6	stable	stable	ADJ
admet-1845	87	7	regardless	regardless	ADV
admet-1845	87	8	of	of	ADP
admet-1845	87	9	ph	ph	ADJ
admet-1845	87	10	change	change	NOUN
admet-1845	87	11	.	.	PUNCT
admet-1845	88	1	this	this	PRON
admet-1845	88	2	might	might	AUX
admet-1845	88	3	be	be	AUX
admet-1845	88	4	explained	explain	VERB
admet-1845	88	5	that	that	SCONJ
admet-1845	88	6	the	the	DET
admet-1845	88	7	amino	amino	NOUN
admet-1845	88	8	groups	group	NOUN
admet-1845	88	9	of	of	ADP
admet-1845	88	10	the	the	DET
admet-1845	88	11	pmnt	pmnt	NOUN
admet-1845	88	12	segment	segment	NOUN
admet-1845	88	13	disintegrated	disintegrate	VERB
admet-1845	88	14	due	due	ADP
admet-1845	88	15	to	to	ADP
admet-1845	88	16	their	their	PRON
admet-1845	88	17	protonation	protonation	NOUN
admet-1845	88	18	at	at	ADP
admet-1845	88	19	low	low	ADJ
admet-1845	88	20	ph	ph	PROPN
admet-1845	88	21	.	.	PROPN
admet-1845	88	22	however	however	ADV
admet-1845	88	23	,	,	PUNCT
admet-1845	88	24	adding	add	VERB
admet-1845	88	25	silica	silica	NOUN
admet-1845	88	26	would	would	AUX
admet-1845	88	27	maintain	maintain	VERB
admet-1845	88	28	the	the	DET
admet-1845	88	29	structure	structure	NOUN
admet-1845	88	30	of	of	ADP
admet-1845	88	31	nps	nps	PROPN
admet-1845	88	32	at	at	ADP
admet-1845	88	33	acidic	acidic	ADJ
admet-1845	88	34	ph	ph	NOUN
admet-1845	88	35	,	,	PUNCT
admet-1845	88	36	resulting	result	VERB
admet-1845	88	37	in	in	ADP
admet-1845	88	38	enhanced	enhanced	ADJ
admet-1845	88	39	stability	stability	NOUN
admet-1845	88	40	.	.	PUNCT
admet-1845	89	1	figure	figure	VERB
admet-1845	89	2	2	2	NUM
admet-1845	89	3	.	.	PUNCT
admet-1845	89	4	characterization	characterization	NOUN
admet-1845	89	5	of	of	ADP
admet-1845	89	6	rnpn	rnpn	PROPN
admet-1845	89	7	and	and	CCONJ
admet-1845	89	8	sirnp	sirnp	PROPN
admet-1845	89	9	.	.	PUNCT
admet-1845	90	1	the	the	DET
admet-1845	90	2	micelles	micelle	NOUN
admet-1845	90	3	were	be	AUX
admet-1845	90	4	obtained	obtain	VERB
admet-1845	90	5	by	by	ADP
admet-1845	90	6	self	self	NOUN
admet-1845	90	7	-	-	PUNCT
admet-1845	90	8	assembly	assembly	NOUN
admet-1845	90	9	amphiphilic	amphiphilic	ADJ
admet-1845	90	10	copolymers	copolymer	NOUN
admet-1845	90	11	peg	peg	NOUN
admet-1845	90	12	-	-	PUNCT
admet-1845	90	13	b	b	NOUN
admet-1845	90	14	-	-	PUNCT
admet-1845	90	15	pmnt	pmnt	NOUN
admet-1845	90	16	and	and	CCONJ
admet-1845	90	17	the	the	DET
admet-1845	90	18	addition	addition	NOUN
admet-1845	90	19	of	of	ADP
admet-1845	90	20	silanol	silanol	ADJ
admet-1845	90	21	groups	group	NOUN
admet-1845	90	22	through	through	ADP
admet-1845	90	23	the	the	DET
admet-1845	90	24	dialysis	dialysis	NOUN
admet-1845	90	25	method	method	NOUN
admet-1845	90	26	for	for	ADP
admet-1845	90	27	rnp	rnp	PROPN
admet-1845	90	28	n	n	PROPN
admet-1845	90	29	and	and	CCONJ
admet-1845	90	30	sirnp	sirnp	PROPN
admet-1845	90	31	,	,	PUNCT
admet-1845	90	32	respectively	respectively	ADV
admet-1845	90	33	,	,	PUNCT
admet-1845	90	34	and	and	CCONJ
admet-1845	90	35	then	then	ADV
admet-1845	90	36	characterized	characterize	VERB
admet-1845	90	37	by	by	ADP
admet-1845	90	38	the	the	DET
admet-1845	90	39	dls	dls	PROPN
admet-1845	90	40	system	system	NOUN
admet-1845	90	41	.	.	PUNCT
admet-1845	91	1	(	(	PUNCT
admet-1845	91	2	a	a	X
admet-1845	91	3	)	)	PUNCT
admet-1845	91	4	the	the	DET
admet-1845	91	5	photographs	photograph	NOUN
admet-1845	91	6	after	after	ADP
admet-1845	91	7	dialysis	dialysis	NOUN
admet-1845	91	8	for	for	ADP
admet-1845	91	9	24	24	NUM
admet-1845	91	10	h.	h.	PROPN
admet-1845	91	11	(	(	PUNCT
admet-1845	91	12	b	b	NOUN
admet-1845	91	13	)	)	PUNCT
admet-1845	91	14	average	average	ADJ
admet-1845	91	15	size	size	NOUN
admet-1845	91	16	.	.	PUNCT
admet-1845	92	1	(	(	PUNCT
admet-1845	92	2	c	c	X
admet-1845	92	3	)	)	PUNCT
admet-1845	92	4	size	size	NOUN
admet-1845	92	5	distribution	distribution	NOUN
admet-1845	92	6	.	.	PUNCT
admet-1845	93	1	(	(	PUNCT
admet-1845	93	2	d	d	X
admet-1845	93	3	)	)	PUNCT
admet-1845	93	4	the	the	DET
admet-1845	93	5	stability	stability	NOUN
admet-1845	93	6	of	of	ADP
admet-1845	93	7	rnpn	rnpn	PROPN
admet-1845	93	8	and	and	CCONJ
admet-1845	93	9	sirnp	sirnp	PROPN
admet-1845	93	10	in	in	ADP
admet-1845	93	11	pbs	pbs	PROPN
admet-1845	93	12	with	with	ADP
admet-1845	93	13	different	different	ADJ
admet-1845	93	14	phs	phs	NOUN
admet-1845	93	15	,	,	PUNCT
admet-1845	93	16	including	include	VERB
admet-1845	93	17	3	3	NUM
admet-1845	93	18	,	,	PUNCT
admet-1845	93	19	6.5	6.5	NUM
admet-1845	93	20	,	,	PUNCT
admet-1845	93	21	and	and	CCONJ
admet-1845	93	22	7.4	7.4	NUM
admet-1845	93	23	simulated	simulate	VERB
admet-1845	93	24	for	for	ADP
admet-1845	93	25	the	the	DET
admet-1845	93	26	gastric	gastric	NOUN
admet-1845	93	27	,	,	PUNCT
admet-1845	93	28	tumor	tumor	NOUN
admet-1845	93	29	extracellular	extracellular	ADJ
admet-1845	93	30	,	,	PUNCT
admet-1845	93	31	and	and	CCONJ
admet-1845	93	32	physiological	physiological	ADJ
admet-1845	93	33	environments	environment	NOUN
admet-1845	93	34	,	,	PUNCT
admet-1845	93	35	respectively	respectively	ADV
admet-1845	93	36	.	.	PUNCT
admet-1845	94	1	data	datum	NOUN
admet-1845	94	2	were	be	AUX
admet-1845	94	3	presented	present	VERB
admet-1845	94	4	as	as	ADP
admet-1845	94	5	the	the	DET
admet-1845	94	6	mean	mean	PROPN
admet-1845	94	7	±	±	NUM
admet-1845	94	8	standard	standard	ADJ
admet-1845	94	9	deviation	deviation	NOUN
admet-1845	94	10	(	(	PUNCT
admet-1845	94	11	sd	sd	NOUN
admet-1845	94	12	)	)	PUNCT
admet-1845	94	13	;	;	PUNCT
admet-1845	94	14	n	n	CCONJ
admet-1845	94	15	=3	=3	VERB
admet-1845	94	16	;	;	PUNCT
admet-1845	94	17	p	p	X
admet-1845	94	18	<	<	X
admet-1845	94	19	0.05	0.05	NUM
admet-1845	94	20	(	(	PUNCT
admet-1845	94	21	*	*	NOUN
admet-1845	94	22	)	)	PUNCT
admet-1845	94	23	;	;	PUNCT
admet-1845	94	24	ns	ns	PROPN
admet-1845	94	25	=	=	VERB
admet-1845	94	26	non	non	ADJ
admet-1845	94	27	-	-	ADJ
admet-1845	94	28	significant	significant	ADJ
admet-1845	94	29	.	.	PUNCT
admet-1845	95	1	characterization	characterization	NOUN
admet-1845	95	2	of	of	ADP
admet-1845	95	3	dox@rnpn	dox@rnpn	NOUN
admet-1845	95	4	and	and	CCONJ
admet-1845	95	5	dox@sirnp	dox@sirnp	PROPN
admet-1845	95	6	dox@rnpn	dox@rnpn	PROPN
admet-1845	95	7	and	and	CCONJ
admet-1845	95	8	dox@sirnp	dox@sirnp	PROPN
admet-1845	95	9	were	be	AUX
admet-1845	95	10	similarly	similarly	ADV
admet-1845	95	11	prepared	prepare	VERB
admet-1845	95	12	as	as	ADP
admet-1845	95	13	rnpn	rnpn	NOUN
admet-1845	95	14	and	and	CCONJ
admet-1845	95	15	sirnp	sirnp	PROPN
admet-1845	95	16	,	,	PUNCT
admet-1845	95	17	respectively	respectively	ADV
admet-1845	95	18	,	,	PUNCT
admet-1845	95	19	except	except	SCONJ
admet-1845	95	20	for	for	ADP
admet-1845	95	21	the	the	DET
admet-1845	95	22	addition	addition	NOUN
admet-1845	95	23	of	of	ADP
admet-1845	95	24	dox	dox	NOUN
admet-1845	95	25	during	during	ADP
admet-1845	95	26	the	the	DET
admet-1845	95	27	preparation	preparation	NOUN
admet-1845	95	28	process	process	NOUN
admet-1845	95	29	.	.	PUNCT
admet-1845	96	1	different	different	ADJ
admet-1845	96	2	concentrations	concentration	NOUN
admet-1845	96	3	of	of	ADP
admet-1845	96	4	nh3	nh3	PROPN
admet-1845	96	5	might	might	AUX
admet-1845	96	6	result	result	VERB
admet-1845	96	7	in	in	ADP
admet-1845	96	8	a	a	DET
admet-1845	96	9	change	change	NOUN
admet-1845	96	10	in	in	ADP
admet-1845	96	11	the	the	DET
admet-1845	96	12	size	size	NOUN
admet-1845	96	13	of	of	ADP
admet-1845	96	14	silica	silica	NOUN
admet-1845	96	15	nps	nps	PROPN
admet-1845	96	16	despite	despite	SCONJ
admet-1845	96	17	its	its	PRON
admet-1845	96	18	catalyzation	catalyzation	NOUN
admet-1845	96	19	role	role	NOUN
admet-1845	96	20	in	in	ADP
admet-1845	96	21	sol	sol	NOUN
admet-1845	96	22	-	-	PUNCT
admet-1845	96	23	gel	gel	NOUN
admet-1845	96	24	reactions	reaction	NOUN
admet-1845	96	25	[	[	X
admet-1845	96	26	24	24	NUM
admet-1845	96	27	]	]	PUNCT
admet-1845	96	28	.	.	PUNCT
admet-1845	97	1	thus	thus	ADV
admet-1845	97	2	,	,	PUNCT
admet-1845	97	3	different	different	ADJ
admet-1845	97	4	ratios	ratio	NOUN
admet-1845	97	5	of	of	ADP
admet-1845	97	6	teos	teo	NOUN
admet-1845	97	7	:	:	PUNCT
admet-1845	97	8	nh3	nh3	PROPN
admet-1845	97	9	were	be	AUX
admet-1845	97	10	examined	examine	VERB
admet-1845	97	11	to	to	PART
admet-1845	97	12	prepare	prepare	VERB
admet-1845	97	13	dox@sirnp	dox@sirnp	PROPN
admet-1845	97	14	with	with	ADP
admet-1845	97	15	the	the	DET
admet-1845	97	16	nano	nano	NOUN
admet-1845	97	17	-	-	PUNCT
admet-1845	97	18	size	size	NOUN
admet-1845	97	19	distribution	distribution	NOUN
admet-1845	97	20	.	.	PUNCT
admet-1845	98	1	as	as	SCONJ
admet-1845	98	2	shown	show	VERB
admet-1845	98	3	in	in	ADP
admet-1845	98	4	figure	figure	NOUN
admet-1845	98	5	3a	3a	NUM
admet-1845	98	6	,	,	PUNCT
admet-1845	98	7	dox@rnpn	dox@rnpn	NOUN
admet-1845	98	8	,	,	PUNCT
admet-1845	98	9	dox@sirnp	dox@sirnp	PROPN
admet-1845	98	10	with	with	ADP
admet-1845	98	11	ratios	ratio	NOUN
admet-1845	98	12	of	of	ADP
admet-1845	98	13	50	50	NUM
admet-1845	98	14	μl	μl	ADP
admet-1845	98	15	teos	teo	NOUN
admet-1845	98	16	:	:	PUNCT
admet-1845	98	17	50	50	NUM
admet-1845	98	18	μl	μl	ADV
admet-1845	98	19	nh3	nh3	NOUN
admet-1845	98	20	and	and	CCONJ
admet-1845	98	21	100	100	NUM
admet-1845	98	22	μl	μl	ADP
admet-1845	98	23	teos	teo	NOUN
admet-1845	98	24	:	:	PUNCT
admet-1845	98	25	50	50	NUM
admet-1845	98	26	μl	μl	PRON
admet-1845	98	27	nh3	nh3	NOUN
admet-1845	98	28	were	be	AUX
admet-1845	98	29	transparent	transparent	ADJ
admet-1845	98	30	,	,	PUNCT
admet-1845	98	31	resulting	result	VERB
admet-1845	98	32	in	in	ADP
admet-1845	98	33	https://doi.org/10.5599/admet.1845	https://doi.org/10.5599/admet.1845	NOUN
admet-1845	98	34	m.-d	m.-d	PROPN
admet-1845	98	35	.	.	PUNCT
admet-1845	99	1	quoc	quoc	PROPN
admet-1845	99	2	tang	tang	INTJ
admet-1845	99	3	et	et	PROPN
admet-1845	99	4	al	al	PROPN
admet-1845	99	5	.	.	PROPN
admet-1845	99	6	admet	admet	PROPN
admet-1845	99	7	&	&	CCONJ
admet-1845	99	8	dmpk	dmpk	PROPN
admet-1845	99	9	11(4	11(4	NUM
admet-1845	99	10	)	)	PUNCT
admet-1845	99	11	(	(	PUNCT
admet-1845	99	12	2023	2023	NUM
admet-1845	99	13	)	)	PUNCT
admet-1845	99	14	551	551	NUM
admet-1845	99	15	-	-	SYM
admet-1845	99	16	560	560	NUM
admet-1845	99	17	556	556	NUM
admet-1845	99	18	the	the	DET
admet-1845	99	19	nano	nano	NOUN
admet-1845	99	20	-	-	PUNCT
admet-1845	99	21	size	size	NOUN
admet-1845	99	22	distribution	distribution	NOUN
admet-1845	99	23	as	as	SCONJ
admet-1845	99	24	compared	compare	VERB
admet-1845	99	25	to	to	ADP
admet-1845	99	26	other	other	ADJ
admet-1845	99	27	samples	sample	NOUN
admet-1845	99	28	with	with	ADP
admet-1845	99	29	turbidity	turbidity	NOUN
admet-1845	99	30	in	in	ADP
admet-1845	99	31	solution	solution	NOUN
admet-1845	99	32	and	and	CCONJ
admet-1845	99	33	micro	micro	NOUN
admet-1845	99	34	-	-	NOUN
admet-1845	99	35	size	size	NOUN
admet-1845	99	36	distribution	distribution	NOUN
admet-1845	99	37	(	(	PUNCT
admet-1845	99	38	data	datum	NOUN
admet-1845	99	39	not	not	PART
admet-1845	99	40	shown	show	VERB
admet-1845	99	41	)	)	PUNCT
admet-1845	99	42	.	.	PUNCT
admet-1845	100	1	hence	hence	ADV
admet-1845	100	2	,	,	PUNCT
admet-1845	100	3	dox@sirnp	dox@sirnp	PROPN
admet-1845	100	4	with	with	ADP
admet-1845	100	5	a	a	DET
admet-1845	100	6	ratio	ratio	NOUN
admet-1845	100	7	of	of	ADP
admet-1845	100	8	50	50	NUM
admet-1845	100	9	μl	μl	ADP
admet-1845	100	10	teos	teo	NOUN
admet-1845	100	11	:	:	PUNCT
admet-1845	100	12	50	50	NUM
admet-1845	100	13	μl	μl	PRON
admet-1845	100	14	nh3	nh3	NOUN
admet-1845	100	15	was	be	AUX
admet-1845	100	16	chosen	choose	VERB
admet-1845	100	17	for	for	ADP
admet-1845	100	18	further	further	ADJ
admet-1845	100	19	experiments	experiment	NOUN
admet-1845	100	20	because	because	SCONJ
admet-1845	100	21	of	of	ADP
admet-1845	100	22	its	its	PRON
admet-1845	100	23	suitable	suitable	ADJ
admet-1845	100	24	size	size	NOUN
admet-1845	100	25	.	.	PUNCT
admet-1845	101	1	as	as	SCONJ
admet-1845	101	2	compared	compare	VERB
admet-1845	101	3	to	to	ADP
admet-1845	101	4	nps	nps	PROPN
admet-1845	101	5	,	,	PUNCT
admet-1845	101	6	the	the	DET
admet-1845	101	7	size	size	NOUN
admet-1845	101	8	of	of	ADP
admet-1845	101	9	both	both	CCONJ
admet-1845	101	10	dox@rnpn	dox@rnpn	NOUN
admet-1845	101	11	and	and	CCONJ
admet-1845	101	12	dox@sirnp	dox@sirnp	PROPN
admet-1845	101	13	significantly	significantly	ADV
admet-1845	101	14	increased	increase	VERB
admet-1845	101	15	to	to	ADP
admet-1845	101	16	56	56	NUM
admet-1845	101	17	and	and	CCONJ
admet-1845	101	18	90	90	NUM
admet-1845	101	19	nm	nm	NOUN
admet-1845	101	20	,	,	PUNCT
admet-1845	101	21	respectively	respectively	ADV
admet-1845	101	22	,	,	PUNCT
admet-1845	101	23	implying	imply	VERB
admet-1845	101	24	the	the	DET
admet-1845	101	25	encapsulation	encapsulation	NOUN
admet-1845	101	26	of	of	ADP
admet-1845	101	27	dox	dox	NOUN
admet-1845	101	28	in	in	ADP
admet-1845	101	29	nps	nps	PROPN
admet-1845	101	30	(	(	PUNCT
admet-1845	101	31	figure	figure	NOUN
admet-1845	101	32	3b	3b	NUM
admet-1845	101	33	)	)	PUNCT
admet-1845	101	34	.	.	PUNCT
admet-1845	102	1	the	the	DET
admet-1845	102	2	critical	critical	ADJ
admet-1845	102	3	cut	cut	NOUN
admet-1845	102	4	-	-	PUNCT
admet-1845	102	5	off	off	ADP
admet-1845	102	6	point	point	NOUN
admet-1845	102	7	for	for	ADP
admet-1845	102	8	endocytosis	endocytosis	NOUN
admet-1845	102	9	has	have	AUX
admet-1845	102	10	been	be	AUX
admet-1845	102	11	estimated	estimate	VERB
admet-1845	102	12	from	from	ADP
admet-1845	102	13	20	20	NUM
admet-1845	102	14	to	to	PART
admet-1845	102	15	500	500	NUM
admet-1845	102	16	nm	nm	NOUN
admet-1845	102	17	for	for	ADP
admet-1845	102	18	m	m	PROPN
admet-1845	102	19	cells	cell	NOUN
admet-1845	102	20	and	and	CCONJ
admet-1845	102	21	from	from	ADP
admet-1845	102	22	approximately	approximately	ADV
admet-1845	102	23	50	50	NUM
admet-1845	102	24	to	to	ADP
admet-1845	102	25	around	around	ADP
admet-1845	102	26	100	100	NUM
admet-1845	102	27	nm	nm	NOUN
admet-1845	102	28	for	for	ADP
admet-1845	102	29	enterocyte	enterocyte	NOUN
admet-1845	102	30	cells	cell	NOUN
admet-1845	102	31	[	[	X
admet-1845	102	32	25	25	NUM
admet-1845	102	33	]	]	PUNCT
admet-1845	102	34	.	.	PUNCT
admet-1845	103	1	therefore	therefore	ADV
admet-1845	103	2	,	,	PUNCT
admet-1845	103	3	dox@rnpn	dox@rnpn	PROPN
admet-1845	103	4	and	and	CCONJ
admet-1845	103	5	dox@sirnp	dox@sirnp	PROPN
admet-1845	103	6	showed	show	VERB
admet-1845	103	7	the	the	DET
admet-1845	103	8	potential	potential	NOUN
admet-1845	103	9	to	to	PART
admet-1845	103	10	increase	increase	VERB
admet-1845	103	11	the	the	DET
admet-1845	103	12	oral	oral	ADJ
admet-1845	103	13	bioavailability	bioavailability	NOUN
admet-1845	103	14	of	of	ADP
admet-1845	103	15	dox	dox	NOUN
admet-1845	103	16	.	.	PUNCT
admet-1845	104	1	moreover	moreover	ADV
admet-1845	104	2	,	,	PUNCT
admet-1845	104	3	the	the	DET
admet-1845	104	4	pdi	pdi	NOUN
admet-1845	104	5	of	of	ADP
admet-1845	104	6	both	both	DET
admet-1845	104	7	nps	nps	PROPN
admet-1845	104	8	was	be	AUX
admet-1845	104	9	around	around	ADV
admet-1845	104	10	0.3	0.3	NUM
admet-1845	104	11	,	,	PUNCT
admet-1845	104	12	indicating	indicate	VERB
admet-1845	104	13	the	the	DET
admet-1845	104	14	narrow	narrow	ADJ
admet-1845	104	15	size	size	NOUN
admet-1845	104	16	distribution	distribution	NOUN
admet-1845	104	17	even	even	ADV
admet-1845	104	18	after	after	ADP
admet-1845	104	19	drug	drug	NOUN
admet-1845	104	20	encapsulation	encapsulation	NOUN
admet-1845	104	21	(	(	PUNCT
admet-1845	104	22	figure	figure	NOUN
admet-1845	104	23	3c	3c	NUM
admet-1845	104	24	)	)	PUNCT
admet-1845	104	25	.	.	PUNCT
admet-1845	105	1	conventionally	conventionally	ADV
admet-1845	105	2	,	,	PUNCT
admet-1845	105	3	polymeric	polymeric	ADJ
admet-1845	105	4	nps	nps	PROPN
admet-1845	105	5	exhibit	exhibit	VERB
admet-1845	105	6	a	a	DET
admet-1845	105	7	low	low	ADJ
admet-1845	105	8	ee	ee	NOUN
admet-1845	105	9	by	by	ADP
admet-1845	105	10	physical	physical	ADJ
admet-1845	105	11	entrapment	entrapment	NOUN
admet-1845	105	12	of	of	ADP
admet-1845	105	13	the	the	DET
admet-1845	105	14	drug	drug	NOUN
admet-1845	105	15	(	(	PUNCT
admet-1845	105	16	less	less	ADJ
admet-1845	105	17	than	than	ADP
admet-1845	105	18	10	10	NUM
admet-1845	105	19	%	%	NOUN
admet-1845	105	20	)	)	PUNCT
admet-1845	106	1	[	[	X
admet-1845	106	2	26	26	NUM
admet-1845	106	3	-	-	SYM
admet-1845	106	4	28	28	NUM
admet-1845	106	5	]	]	PUNCT
admet-1845	106	6	.	.	PUNCT
admet-1845	107	1	for	for	ADP
admet-1845	107	2	example	example	NOUN
admet-1845	107	3	,	,	PUNCT
admet-1845	107	4	the	the	DET
admet-1845	107	5	lc	lc	PROPN
admet-1845	107	6	of	of	ADP
admet-1845	107	7	dox	dox	NOUN
admet-1845	107	8	-	-	PUNCT
admet-1845	107	9	loaded	load	VERB
admet-1845	107	10	silica	silica	NOUN
admet-1845	107	11	nps	nps	PROPN
admet-1845	107	12	was	be	AUX
admet-1845	107	13	reported	report	VERB
admet-1845	107	14	at	at	ADP
admet-1845	107	15	4.8	4.8	NUM
admet-1845	107	16	%	%	NOUN
admet-1845	107	17	[	[	X
admet-1845	107	18	29	29	NUM
admet-1845	107	19	]	]	PUNCT
admet-1845	107	20	.	.	PUNCT
admet-1845	108	1	as	as	SCONJ
admet-1845	108	2	shown	show	VERB
admet-1845	108	3	in	in	ADP
admet-1845	108	4	figure	figure	NOUN
admet-1845	108	5	3d	3d	NOUN
admet-1845	108	6	,	,	PUNCT
admet-1845	108	7	the	the	DET
admet-1845	108	8	ee	ee	PROPN
admet-1845	108	9	was	be	AUX
admet-1845	108	10	20.3	20.3	NUM
admet-1845	108	11	and	and	CCONJ
admet-1845	108	12	74.9	74.9	NUM
admet-1845	108	13	%	%	NOUN
admet-1845	108	14	,	,	PUNCT
admet-1845	108	15	and	and	CCONJ
admet-1845	108	16	the	the	DET
admet-1845	108	17	lc	lc	NOUN
admet-1845	108	18	was	be	AUX
admet-1845	108	19	1.5	1.5	NUM
admet-1845	108	20	and	and	CCONJ
admet-1845	108	21	5	5	NUM
admet-1845	108	22	%	%	NOUN
admet-1845	108	23	for	for	ADP
admet-1845	108	24	dox@rnpn	dox@rnpn	NOUN
admet-1845	108	25	and	and	CCONJ
admet-1845	108	26	dox@sirnp	dox@sirnp	PROPN
admet-1845	108	27	,	,	PUNCT
admet-1845	108	28	respectively	respectively	ADV
admet-1845	108	29	.	.	PUNCT
admet-1845	109	1	this	this	DET
admet-1845	109	2	result	result	NOUN
admet-1845	109	3	indicates	indicate	VERB
admet-1845	109	4	the	the	DET
admet-1845	109	5	appropriate	appropriate	ADJ
admet-1845	109	6	design	design	NOUN
admet-1845	109	7	of	of	ADP
admet-1845	109	8	the	the	DET
admet-1845	109	9	dox	dox	NOUN
admet-1845	109	10	encapsulation	encapsulation	NOUN
admet-1845	109	11	because	because	SCONJ
admet-1845	109	12	the	the	DET
admet-1845	109	13	silanol	silanol	NOUN
admet-1845	109	14	groups	group	NOUN
admet-1845	109	15	in	in	ADP
admet-1845	109	16	the	the	DET
admet-1845	109	17	core	core	NOUN
admet-1845	109	18	of	of	ADP
admet-1845	109	19	sirnp	sirnp	PROPN
admet-1845	109	20	significantly	significantly	ADV
admet-1845	109	21	improved	improve	VERB
admet-1845	109	22	the	the	DET
admet-1845	109	23	ee	ee	NOUN
admet-1845	109	24	and	and	CCONJ
admet-1845	109	25	lc	lc	PROPN
admet-1845	109	26	of	of	ADP
admet-1845	109	27	dox	dox	NOUN
admet-1845	109	28	.	.	PUNCT
admet-1845	110	1	this	this	DET
admet-1845	110	2	result	result	NOUN
admet-1845	110	3	could	could	AUX
admet-1845	110	4	be	be	AUX
admet-1845	110	5	explained	explain	VERB
admet-1845	110	6	by	by	ADP
admet-1845	110	7	the	the	DET
admet-1845	110	8	pka	pka	PROPN
admet-1845	110	9	of	of	ADP
admet-1845	110	10	the	the	DET
admet-1845	110	11	amino	amino	NOUN
admet-1845	110	12	group	group	NOUN
admet-1845	110	13	in	in	ADP
admet-1845	110	14	dox	dox	NOUN
admet-1845	110	15	being	be	AUX
admet-1845	110	16	around	around	ADP
admet-1845	110	17	9.9	9.9	NUM
admet-1845	110	18	,	,	PUNCT
admet-1845	110	19	thus	thus	ADV
admet-1845	110	20	most	most	ADJ
admet-1845	110	21	dox	dox	ADJ
admet-1845	110	22	molecules	molecule	NOUN
admet-1845	110	23	are	be	AUX
admet-1845	110	24	in	in	ADP
admet-1845	110	25	the	the	DET
admet-1845	110	26	positively	positively	ADV
admet-1845	110	27	charged	charge	VERB
admet-1845	110	28	form	form	NOUN
admet-1845	110	29	at	at	ADP
admet-1845	110	30	physiological	physiological	ADJ
admet-1845	110	31	ph	ph	NOUN
admet-1845	111	1	[	[	X
admet-1845	111	2	30	30	NUM
admet-1845	111	3	]	]	PUNCT
admet-1845	111	4	.	.	PUNCT
admet-1845	112	1	consequently	consequently	ADV
admet-1845	112	2	,	,	PUNCT
admet-1845	112	3	silanol	silanol	NOUN
admet-1845	112	4	moieties	moiety	NOUN
admet-1845	112	5	possessing	possess	VERB
admet-1845	112	6	a	a	DET
admet-1845	112	7	negatively	negatively	ADV
admet-1845	112	8	charged	charge	VERB
admet-1845	112	9	surface	surface	NOUN
admet-1845	112	10	could	could	AUX
admet-1845	112	11	interact	interact	VERB
admet-1845	112	12	with	with	ADP
admet-1845	112	13	dox	dox	NOUN
admet-1845	112	14	by	by	ADP
admet-1845	112	15	electrostatics	electrostatic	NOUN
admet-1845	112	16	,	,	PUNCT
admet-1845	112	17	suggesting	suggest	VERB
admet-1845	112	18	the	the	DET
admet-1845	112	19	enhancement	enhancement	NOUN
admet-1845	112	20	in	in	ADP
admet-1845	112	21	ee	ee	PROPN
admet-1845	112	22	and	and	CCONJ
admet-1845	112	23	lc	lc	PROPN
admet-1845	112	24	of	of	ADP
admet-1845	112	25	dox@sirnp	dox@sirnp	PROPN
admet-1845	112	26	.	.	PUNCT
admet-1845	113	1	figure	figure	NOUN
admet-1845	113	2	.	.	PUNCT
admet-1845	114	1	3	3	X
admet-1845	114	2	.	.	X
admet-1845	114	3	characterization	characterization	NOUN
admet-1845	114	4	of	of	ADP
admet-1845	114	5	dox@rnpn	dox@rnpn	NOUN
admet-1845	114	6	and	and	CCONJ
admet-1845	114	7	dox@sirnp	dox@sirnp	PROPN
admet-1845	114	8	.	.	PUNCT
admet-1845	115	1	the	the	DET
admet-1845	115	2	method	method	NOUN
admet-1845	115	3	for	for	ADP
admet-1845	115	4	preparation	preparation	NOUN
admet-1845	115	5	of	of	ADP
admet-1845	115	6	dox@rnpn	dox@rnpn	NOUN
admet-1845	115	7	and	and	CCONJ
admet-1845	115	8	dox@sirnp	dox@sirnp	PROPN
admet-1845	115	9	was	be	AUX
admet-1845	115	10	similar	similar	ADJ
admet-1845	115	11	to	to	ADP
admet-1845	115	12	the	the	DET
admet-1845	115	13	method	method	NOUN
admet-1845	115	14	of	of	ADP
admet-1845	115	15	rnpn	rnpn	NOUN
admet-1845	115	16	and	and	CCONJ
admet-1845	115	17	sirnp	sirnp	PROPN
admet-1845	115	18	except	except	SCONJ
admet-1845	115	19	for	for	ADP
admet-1845	115	20	the	the	DET
admet-1845	115	21	incorporation	incorporation	NOUN
admet-1845	115	22	of	of	ADP
admet-1845	115	23	dox	dox	NOUN
admet-1845	115	24	during	during	ADP
admet-1845	115	25	the	the	DET
admet-1845	115	26	stirring	stirring	NOUN
admet-1845	115	27	process	process	NOUN
admet-1845	115	28	.	.	PUNCT
admet-1845	116	1	(	(	PUNCT
admet-1845	116	2	a	a	X
admet-1845	116	3	)	)	PUNCT
admet-1845	116	4	the	the	DET
admet-1845	116	5	photographs	photograph	NOUN
admet-1845	116	6	of	of	ADP
admet-1845	116	7	dox@rnpn	dox@rnpn	NOUN
admet-1845	116	8	and	and	CCONJ
admet-1845	116	9	dox@sirnp	dox@sirnp	PROPN
admet-1845	116	10	with	with	ADP
admet-1845	116	11	different	different	ADJ
admet-1845	116	12	ratios	ratio	NOUN
admet-1845	116	13	of	of	ADP
admet-1845	116	14	teos	teo	NOUN
admet-1845	116	15	:	:	PUNCT
admet-1845	116	16	nh3	nh3	NOUN
admet-1845	116	17	after	after	ADP
admet-1845	116	18	dialysis	dialysis	NOUN
admet-1845	116	19	for	for	ADP
admet-1845	116	20	24	24	NUM
admet-1845	116	21	h.	h.	PROPN
admet-1845	116	22	(	(	PUNCT
admet-1845	116	23	b	b	NOUN
admet-1845	116	24	)	)	PUNCT
admet-1845	116	25	average	average	ADJ
admet-1845	116	26	size	size	NOUN
admet-1845	116	27	.	.	PUNCT
admet-1845	117	1	(	(	PUNCT
admet-1845	117	2	c	c	X
admet-1845	117	3	)	)	PUNCT
admet-1845	117	4	size	size	NOUN
admet-1845	117	5	distribution	distribution	NOUN
admet-1845	117	6	.	.	PUNCT
admet-1845	118	1	(	(	PUNCT
admet-1845	118	2	d	d	X
admet-1845	118	3	)	)	PUNCT
admet-1845	118	4	the	the	DET
admet-1845	118	5	ee	ee	PROPN
admet-1845	118	6	and	and	CCONJ
admet-1845	118	7	lc	lc	PROPN
admet-1845	118	8	of	of	ADP
admet-1845	118	9	dox@rnp	dox@rnp	PROPN
admet-1845	118	10	n	n	PROPN
admet-1845	118	11	and	and	CCONJ
admet-1845	118	12	dox@sirnp	dox@sirnp	PROPN
admet-1845	118	13	were	be	AUX
admet-1845	118	14	obtained	obtain	VERB
admet-1845	118	15	by	by	ADP
admet-1845	118	16	measuring	measure	VERB
admet-1845	118	17	the	the	DET
admet-1845	118	18	absorbance	absorbance	NOUN
admet-1845	118	19	at	at	ADP
admet-1845	118	20	480	480	NUM
admet-1845	118	21	nm	nm	NOUN
admet-1845	118	22	.	.	PUNCT
admet-1845	119	1	data	datum	NOUN
admet-1845	119	2	were	be	AUX
admet-1845	119	3	presented	present	VERB
admet-1845	119	4	as	as	ADP
admet-1845	119	5	the	the	DET
admet-1845	119	6	mean	mean	PROPN
admet-1845	119	7	±	±	NUM
admet-1845	119	8	standard	standard	ADJ
admet-1845	119	9	deviation	deviation	NOUN
admet-1845	119	10	(	(	PUNCT
admet-1845	119	11	sd	sd	NOUN
admet-1845	119	12	)	)	PUNCT
admet-1845	119	13	;	;	PUNCT
admet-1845	119	14	n	n	CCONJ
admet-1845	119	15	=3	=3	VERB
admet-1845	119	16	;	;	PUNCT
admet-1845	119	17	p	p	X
admet-1845	119	18	<	<	X
admet-1845	119	19	0.05	0.05	NUM
admet-1845	119	20	(	(	PUNCT
admet-1845	119	21	*	*	PROPN
admet-1845	119	22	)	)	PUNCT
admet-1845	119	23	;	;	PUNCT
admet-1845	119	24	p	p	X
admet-1845	119	25	<	<	X
admet-1845	119	26	0.01	0.01	NUM
admet-1845	119	27	(	(	PUNCT
admet-1845	119	28	*	*	NOUN
admet-1845	119	29	*	*	PUNCT
admet-1845	119	30	)	)	PUNCT
admet-1845	119	31	.	.	PUNCT
admet-1845	120	1	release	release	VERB
admet-1845	120	2	profile	profile	NOUN
admet-1845	120	3	of	of	ADP
admet-1845	120	4	dox@rnpn	dox@rnpn	NOUN
admet-1845	120	5	and	and	CCONJ
admet-1845	120	6	dox@sirnp	dox@sirnp	VERB
admet-1845	120	7	the	the	DET
admet-1845	120	8	release	release	NOUN
admet-1845	120	9	kinetics	kinetic	NOUN
admet-1845	120	10	of	of	ADP
admet-1845	120	11	dox@rnpn	dox@rnpn	NOUN
admet-1845	120	12	and	and	CCONJ
admet-1845	120	13	dox@sirnp	dox@sirnp	PROPN
admet-1845	120	14	were	be	AUX
admet-1845	120	15	evaluated	evaluate	VERB
admet-1845	120	16	under	under	ADP
admet-1845	120	17	different	different	ADJ
admet-1845	120	18	ph	ph	ADJ
admet-1845	120	19	buffers	buffer	NOUN
admet-1845	120	20	,	,	PUNCT
admet-1845	120	21	including	include	VERB
admet-1845	120	22	ph	ph	PROPN
admet-1845	120	23	3.0	3.0	NUM
admet-1845	120	24	,	,	PUNCT
admet-1845	120	25	6.5	6.5	NUM
admet-1845	120	26	,	,	PUNCT
admet-1845	120	27	and	and	CCONJ
admet-1845	120	28	7.4	7.4	NUM
admet-1845	120	29	,	,	PUNCT
admet-1845	120	30	which	which	PRON
admet-1845	120	31	mimic	mimic	VERB
admet-1845	120	32	the	the	DET
admet-1845	120	33	gastric	gastric	NOUN
admet-1845	120	34	,	,	PUNCT
admet-1845	120	35	tumour	tumour	NOUN
admet-1845	120	36	extracellular	extracellular	ADJ
admet-1845	120	37	,	,	PUNCT
admet-1845	120	38	and	and	CCONJ
admet-1845	120	39	physiological	physiological	ADJ
admet-1845	120	40	ph	ph	VERB
admet-1845	120	41	,	,	PUNCT
admet-1845	120	42	respectively	respectively	ADV
admet-1845	120	43	.	.	PUNCT
admet-1845	121	1	gastric	gastric	ADJ
admet-1845	121	2	ph	ph	PROPN
admet-1845	121	3	is	be	AUX
admet-1845	121	4	one	one	NUM
admet-1845	121	5	of	of	ADP
admet-1845	121	6	the	the	DET
admet-1845	121	7	challenging	challenging	ADJ
admet-1845	121	8	barriers	barrier	NOUN
admet-1845	121	9	for	for	ADP
admet-1845	121	10	oral	oral	ADJ
admet-1845	121	11	drug	drug	NOUN
admet-1845	121	12	delivery	delivery	NOUN
admet-1845	121	13	systems	system	NOUN
admet-1845	121	14	.	.	PUNCT
admet-1845	122	1	as	as	SCONJ
admet-1845	122	2	shown	show	VERB
admet-1845	122	3	in	in	ADP
admet-1845	122	4	figure	figure	NOUN
admet-1845	122	5	4a	4a	NOUN
admet-1845	122	6	,	,	PUNCT
admet-1845	122	7	dox@sirnp	dox@sirnp	PROPN
admet-1845	122	8	was	be	AUX
admet-1845	122	9	released	release	VERB
admet-1845	122	10	significantly	significantly	ADV
admet-1845	122	11	slower	slow	ADJ
admet-1845	122	12	than	than	ADP
admet-1845	122	13	dox@rnpn	dox@rnpn	NOUN
admet-1845	122	14	(	(	PUNCT
admet-1845	122	15	17.8	17.8	NUM
admet-1845	122	16	%	%	NOUN
admet-1845	122	17	compared	compare	VERB
admet-1845	122	18	to	to	ADP
admet-1845	122	19	35.9	35.9	NUM
admet-1845	122	20	%	%	NOUN
admet-1845	122	21	)	)	PUNCT
admet-1845	122	22	after	after	ADP
admet-1845	122	23	24	24	NUM
admet-1845	122	24	h	h	NOUN
admet-1845	122	25	,	,	PUNCT
admet-1845	122	26	even	even	ADV
admet-1845	122	27	though	though	SCONJ
admet-1845	122	28	both	both	DET
admet-1845	122	29	admet	admet	PROPN
admet-1845	122	30	&	&	CCONJ
admet-1845	122	31	dmpk	dmpk	PROPN
admet-1845	122	32	11(4	11(4	NUM
admet-1845	122	33	)	)	PUNCT
admet-1845	122	34	(	(	PUNCT
admet-1845	122	35	2023	2023	NUM
admet-1845	122	36	)	)	PUNCT
admet-1845	122	37	551	551	NUM
admet-1845	122	38	-	-	SYM
admet-1845	122	39	560	560	NUM
admet-1845	122	40	drug	drug	NOUN
admet-1845	122	41	encapsulation	encapsulation	NOUN
admet-1845	122	42	and	and	CCONJ
admet-1845	122	43	suppress	suppress	VERB
admet-1845	122	44	the	the	DET
admet-1845	122	45	adverse	adverse	ADJ
admet-1845	122	46	effect	effect	NOUN
admet-1845	122	47	of	of	ADP
admet-1845	122	48	doxorubicin	doxorubicin	PROPN
admet-1845	122	49	doi	doi	PROPN
admet-1845	122	50	:	:	PUNCT
admet-1845	122	51	https://doi.org/10.5599/adme	https://doi.org/10.5599/adme	PROPN
admet-1845	122	52	t.1845	t.1845	NOUN
admet-1845	122	53	557	557	NUM
admet-1845	122	54	experienced	experienced	ADJ
admet-1845	122	55	protonations	protonation	NOUN
admet-1845	122	56	of	of	ADP
admet-1845	122	57	amino	amino	ADJ
admet-1845	122	58	groups	group	NOUN
admet-1845	122	59	at	at	ADP
admet-1845	122	60	the	the	DET
admet-1845	122	61	hydrophobic	hydrophobic	NOUN
admet-1845	122	62	core	core	NOUN
admet-1845	122	63	.	.	PUNCT
admet-1845	123	1	however	however	ADV
admet-1845	123	2	,	,	PUNCT
admet-1845	123	3	more	more	ADJ
admet-1845	123	4	than	than	ADP
admet-1845	123	5	80	80	NUM
admet-1845	123	6	%	%	NOUN
admet-1845	123	7	of	of	ADP
admet-1845	123	8	dox@rnpn	dox@rnpn	NOUN
admet-1845	123	9	and	and	CCONJ
admet-1845	123	10	90	90	NUM
admet-1845	123	11	%	%	NOUN
admet-1845	123	12	of	of	ADP
admet-1845	123	13	dox@sirnp	dox@sirnp	PROPN
admet-1845	123	14	were	be	AUX
admet-1845	123	15	retained	retain	VERB
admet-1845	123	16	after	after	ADP
admet-1845	123	17	6	6	NUM
admet-1845	123	18	h	h	NOUN
admet-1845	123	19	,	,	PUNCT
admet-1845	123	20	suggesting	suggest	VERB
admet-1845	123	21	their	their	PRON
admet-1845	123	22	potential	potential	NOUN
admet-1845	123	23	for	for	ADP
admet-1845	123	24	in	in	ADP
admet-1845	123	25	vivo	vivo	ADJ
admet-1845	123	26	application	application	NOUN
admet-1845	123	27	as	as	SCONJ
admet-1845	123	28	they	they	PRON
admet-1845	123	29	can	can	AUX
admet-1845	123	30	withstand	withstand	VERB
admet-1845	123	31	the	the	DET
admet-1845	123	32	maximal	maximal	ADJ
admet-1845	123	33	transit	transit	NOUN
admet-1845	123	34	time	time	NOUN
admet-1845	123	35	of	of	ADP
admet-1845	123	36	the	the	DET
admet-1845	123	37	stomach	stomach	NOUN
admet-1845	123	38	in	in	ADP
admet-1845	123	39	the	the	DET
admet-1845	123	40	human	human	ADJ
admet-1845	123	41	body	body	NOUN
admet-1845	123	42	.	.	PUNCT
admet-1845	124	1	the	the	DET
admet-1845	124	2	extracellular	extracellular	ADJ
admet-1845	124	3	ph	ph	NOUN
admet-1845	124	4	of	of	ADP
admet-1845	124	5	tumors	tumor	NOUN
admet-1845	124	6	,	,	PUNCT
admet-1845	124	7	which	which	PRON
admet-1845	124	8	commonly	commonly	ADV
admet-1845	124	9	drops	drop	VERB
admet-1845	124	10	around	around	ADV
admet-1845	124	11	6.5	6.5	NUM
admet-1845	124	12	-	-	SYM
admet-1845	124	13	7.0	7.0	NUM
admet-1845	124	14	,	,	PUNCT
admet-1845	124	15	is	be	AUX
admet-1845	124	16	mainly	mainly	ADV
admet-1845	124	17	caused	cause	VERB
admet-1845	124	18	by	by	ADP
admet-1845	124	19	anaerobic	anaerobic	NOUN
admet-1845	124	20	glycolysis	glycolysis	NOUN
admet-1845	124	21	in	in	ADP
admet-1845	124	22	hypoxia	hypoxia	NOUN
admet-1845	124	23	[	[	X
admet-1845	124	24	31	31	NUM
admet-1845	124	25	]	]	PUNCT
admet-1845	124	26	.	.	PUNCT
admet-1845	125	1	as	as	SCONJ
admet-1845	125	2	shown	show	VERB
admet-1845	125	3	in	in	ADP
admet-1845	125	4	figure	figure	NOUN
admet-1845	125	5	4b	4b	PROPN
admet-1845	125	6	,	,	PUNCT
admet-1845	125	7	the	the	DET
admet-1845	125	8	release	release	NOUN
admet-1845	125	9	profiles	profile	NOUN
admet-1845	125	10	of	of	ADP
admet-1845	125	11	dox@sirnp	dox@sirnp	PROPN
admet-1845	125	12	and	and	CCONJ
admet-1845	125	13	dox@rnpn	dox@rnpn	PROPN
admet-1845	125	14	at	at	ADP
admet-1845	125	15	ph	ph	PROPN
admet-1845	125	16	6.5	6.5	NUM
admet-1845	125	17	were	be	AUX
admet-1845	125	18	16.4	16.4	NUM
admet-1845	125	19	and	and	CCONJ
admet-1845	125	20	33.0	33.0	NUM
admet-1845	125	21	%	%	NOUN
admet-1845	125	22	,	,	PUNCT
admet-1845	125	23	respectively	respectively	ADV
admet-1845	125	24	.	.	PUNCT
admet-1845	126	1	these	these	DET
admet-1845	126	2	results	result	NOUN
admet-1845	126	3	are	be	AUX
admet-1845	126	4	consistent	consistent	ADJ
admet-1845	126	5	with	with	ADP
admet-1845	126	6	the	the	DET
admet-1845	126	7	previous	previous	ADJ
admet-1845	126	8	stability	stability	NOUN
admet-1845	126	9	study	study	NOUN
admet-1845	126	10	.	.	PUNCT
admet-1845	127	1	it	it	PRON
admet-1845	127	2	is	be	AUX
admet-1845	127	3	evident	evident	ADJ
admet-1845	127	4	that	that	SCONJ
admet-1845	127	5	dox@sirnp	dox@sirnp	PROPN
admet-1845	127	6	was	be	AUX
admet-1845	127	7	less	less	ADV
admet-1845	127	8	impacted	impact	VERB
admet-1845	127	9	by	by	ADP
admet-1845	127	10	acidic	acidic	ADJ
admet-1845	127	11	ph	ph	NOUN
admet-1845	127	12	than	than	ADP
admet-1845	127	13	dox@rnpn	dox@rnpn	NOUN
admet-1845	127	14	due	due	ADP
admet-1845	127	15	to	to	ADP
admet-1845	127	16	the	the	DET
admet-1845	127	17	ability	ability	NOUN
admet-1845	127	18	of	of	ADP
admet-1845	127	19	nano	nano	NOUN
admet-1845	127	20	-	-	PUNCT
admet-1845	127	21	silica	silica	NOUN
admet-1845	127	22	to	to	PART
admet-1845	127	23	stabilize	stabilize	VERB
admet-1845	127	24	the	the	DET
admet-1845	127	25	structure	structure	NOUN
admet-1845	127	26	.	.	PUNCT
admet-1845	128	1	after	after	SCONJ
admet-1845	128	2	24	24	NUM
admet-1845	128	3	h	h	NOUN
admet-1845	128	4	at	at	ADP
admet-1845	128	5	physiological	physiological	ADJ
admet-1845	128	6	ph	ph	VERB
admet-1845	128	7	,	,	PUNCT
admet-1845	128	8	dox@rnpn	dox@rnpn	NOUN
admet-1845	128	9	and	and	CCONJ
admet-1845	128	10	dox@sirnp	dox@sirnp	PROPN
admet-1845	128	11	leaked	leak	VERB
admet-1845	128	12	at	at	ADP
admet-1845	128	13	14	14	NUM
admet-1845	128	14	and	and	CCONJ
admet-1845	128	15	15	15	NUM
admet-1845	128	16	%	%	NOUN
admet-1845	128	17	,	,	PUNCT
admet-1845	128	18	respectively	respectively	ADV
admet-1845	128	19	(	(	PUNCT
admet-1845	128	20	figure	figure	NOUN
admet-1845	128	21	4c	4c	NOUN
admet-1845	128	22	)	)	PUNCT
admet-1845	128	23	.	.	PUNCT
admet-1845	129	1	similarly	similarly	ADV
admet-1845	129	2	,	,	PUNCT
admet-1845	129	3	several	several	ADJ
admet-1845	129	4	studies	study	NOUN
admet-1845	129	5	have	have	AUX
admet-1845	129	6	reported	report	VERB
admet-1845	129	7	that	that	SCONJ
admet-1845	129	8	the	the	DET
admet-1845	129	9	release	release	NOUN
admet-1845	129	10	profile	profile	NOUN
admet-1845	129	11	of	of	ADP
admet-1845	129	12	micelle	micelle	PROPN
admet-1845	129	13	nps	nps	PROPN
admet-1845	129	14	with	with	ADP
admet-1845	129	15	ph	ph	ADJ
admet-1845	129	16	-	-	ADJ
admet-1845	129	17	sensitive	sensitive	ADJ
admet-1845	129	18	groups	group	NOUN
admet-1845	129	19	is	be	AUX
admet-1845	129	20	higher	high	ADJ
admet-1845	129	21	at	at	ADP
admet-1845	129	22	acidic	acidic	ADJ
admet-1845	129	23	ph	ph	NOUN
admet-1845	129	24	than	than	ADP
admet-1845	129	25	at	at	ADP
admet-1845	129	26	neutral	neutral	ADJ
admet-1845	129	27	ph	ph	NOUN
admet-1845	130	1	[	[	X
admet-1845	130	2	32,33	32,33	NUM
admet-1845	130	3	]	]	PUNCT
admet-1845	130	4	.	.	PUNCT
admet-1845	131	1	figure	figure	NOUN
admet-1845	131	2	4	4	NUM
admet-1845	131	3	.	.	PUNCT
admet-1845	132	1	the	the	DET
admet-1845	132	2	drug	drug	NOUN
admet-1845	132	3	release	release	NOUN
admet-1845	132	4	of	of	ADP
admet-1845	132	5	dox@rnpn	dox@rnpn	NOUN
admet-1845	132	6	and	and	CCONJ
admet-1845	132	7	dox@sirnp	dox@sirnp	PROPN
admet-1845	132	8	.	.	PUNCT
admet-1845	133	1	the	the	DET
admet-1845	133	2	release	release	NOUN
admet-1845	133	3	of	of	ADP
admet-1845	133	4	dox	dox	NOUN
admet-1845	133	5	in	in	ADP
admet-1845	133	6	pbs	pbs	PROPN
admet-1845	133	7	with	with	ADP
admet-1845	133	8	various	various	ADJ
admet-1845	133	9	ph	ph	NOUN
admet-1845	133	10	including	include	VERB
admet-1845	133	11	3.0	3.0	NUM
admet-1845	133	12	,	,	PUNCT
admet-1845	133	13	6.5	6.5	NUM
admet-1845	133	14	,	,	PUNCT
admet-1845	133	15	and	and	CCONJ
admet-1845	133	16	7.4	7.4	NUM
admet-1845	133	17	was	be	AUX
admet-1845	133	18	identified	identify	VERB
admet-1845	133	19	by	by	ADP
admet-1845	133	20	measuring	measure	VERB
admet-1845	133	21	the	the	DET
admet-1845	133	22	absorbance	absorbance	NOUN
admet-1845	133	23	at	at	ADP
admet-1845	133	24	480	480	NUM
admet-1845	133	25	nm	nm	NOUN
admet-1845	133	26	.	.	PUNCT
admet-1845	134	1	(	(	PUNCT
admet-1845	134	2	a	a	X
admet-1845	134	3	)	)	PUNCT
admet-1845	134	4	ph	ph	PROPN
admet-1845	134	5	3.0	3.0	NUM
admet-1845	134	6	.	.	PUNCT
admet-1845	135	1	(	(	PUNCT
admet-1845	135	2	b	b	NOUN
admet-1845	135	3	)	)	PUNCT
admet-1845	135	4	.	.	PUNCT
admet-1845	136	1	ph	ph	PROPN
admet-1845	136	2	6.5	6.5	NUM
admet-1845	136	3	.	.	PUNCT
admet-1845	137	1	(	(	PUNCT
admet-1845	137	2	c	c	X
admet-1845	137	3	)	)	PUNCT
admet-1845	137	4	ph	ph	NOUN
admet-1845	137	5	7.4	7.4	NUM
admet-1845	137	6	.	.	PUNCT
admet-1845	138	1	data	datum	NOUN
admet-1845	138	2	were	be	AUX
admet-1845	138	3	presented	present	VERB
admet-1845	138	4	as	as	ADP
admet-1845	138	5	the	the	DET
admet-1845	138	6	mean	mean	PROPN
admet-1845	138	7	±	±	NUM
admet-1845	138	8	standard	standard	ADJ
admet-1845	138	9	deviation	deviation	NOUN
admet-1845	138	10	(	(	PUNCT
admet-1845	138	11	sd	sd	NOUN
admet-1845	138	12	)	)	PUNCT
admet-1845	138	13	;	;	PUNCT
admet-1845	138	14	n	n	CCONJ
admet-1845	138	15	=3	=3	VERB
admet-1845	138	16	;	;	PUNCT
admet-1845	138	17	p	p	X
admet-1845	138	18	<	<	X
admet-1845	138	19	0.01	0.01	NUM
admet-1845	138	20	(	(	PUNCT
admet-1845	138	21	*	*	PUNCT
admet-1845	138	22	*	*	PUNCT
admet-1845	138	23	)	)	PUNCT
admet-1845	138	24	;	;	PUNCT
admet-1845	138	25	ns	ns	NUM
admet-1845	138	26	=	=	VERB
admet-1845	138	27	non	non	X
admet-1845	138	28	-significant	-significant	NOUN
admet-1845	138	29	.	.	PUNCT
admet-1845	139	1	in	in	ADP
admet-1845	139	2	vitro	vitro	X
admet-1845	139	3	cytotoxicity	cytotoxicity	NOUN
admet-1845	139	4	the	the	DET
admet-1845	139	5	cytotoxicity	cytotoxicity	NOUN
admet-1845	139	6	of	of	ADP
admet-1845	139	7	nps	nps	PROPN
admet-1845	139	8	was	be	AUX
admet-1845	139	9	assessed	assess	VERB
admet-1845	139	10	through	through	ADP
admet-1845	139	11	mtt	mtt	NOUN
admet-1845	139	12	assay	assay	VERB
admet-1845	139	13	on	on	ADP
admet-1845	139	14	normal	normal	ADJ
admet-1845	139	15	murine	murine	ADJ
admet-1845	139	16	fibroblast	fibroblast	ADJ
admet-1845	139	17	cells	cell	NOUN
admet-1845	139	18	(	(	PUNCT
admet-1845	139	19	l929	l929	NUM
admet-1845	139	20	)	)	PUNCT
admet-1845	139	21	and	and	CCONJ
admet-1845	139	22	cancer	cancer	NOUN
admet-1845	139	23	cells	cell	NOUN
admet-1845	139	24	,	,	PUNCT
admet-1845	139	25	including	include	VERB
admet-1845	139	26	human	human	ADJ
admet-1845	139	27	breast	breast	NOUN
admet-1845	139	28	cancer	cancer	NOUN
admet-1845	139	29	cells	cell	NOUN
admet-1845	139	30	(	(	PUNCT
admet-1845	139	31	mcf-7	mcf-7	NOUN
admet-1845	139	32	)	)	PUNCT
admet-1845	139	33	and	and	CCONJ
admet-1845	139	34	human	human	ADJ
admet-1845	139	35	hepatocellular	hepatocellular	ADJ
admet-1845	139	36	carcinoma	carcinoma	NOUN
admet-1845	139	37	cells	cell	NOUN
admet-1845	139	38	(	(	PUNCT
admet-1845	139	39	hepg2	hepg2	NOUN
admet-1845	139	40	)	)	PUNCT
admet-1845	139	41	.	.	PUNCT
admet-1845	140	1	in	in	ADP
admet-1845	140	2	addition	addition	NOUN
admet-1845	140	3	to	to	ADP
admet-1845	140	4	the	the	DET
admet-1845	140	5	well	well	ADV
admet-1845	140	6	-	-	PUNCT
admet-1845	140	7	known	know	VERB
admet-1845	140	8	anticancer	anticancer	NOUN
admet-1845	140	9	mechanism	mechanism	NOUN
admet-1845	140	10	,	,	PUNCT
admet-1845	140	11	which	which	PRON
admet-1845	140	12	involves	involve	VERB
admet-1845	140	13	interaction	interaction	NOUN
admet-1845	140	14	with	with	ADP
admet-1845	140	15	the	the	DET
admet-1845	140	16	topoisomerases	topoisomerases	PROPN
admet-1845	140	17	ii	ii	PROPN
admet-1845	140	18	to	to	PART
admet-1845	140	19	interfere	interfere	VERB
admet-1845	140	20	with	with	ADP
admet-1845	140	21	dna	dna	PROPN
admet-1845	140	22	replication	replication	NOUN
admet-1845	140	23	,	,	PUNCT
admet-1845	140	24	it	it	PRON
admet-1845	140	25	also	also	ADV
admet-1845	140	26	induces	induce	VERB
admet-1845	140	27	the	the	DET
admet-1845	140	28	over	over	NOUN
admet-1845	140	29	-	-	PUNCT
admet-1845	140	30	expression	expression	NOUN
admet-1845	140	31	of	of	ADP
admet-1845	140	32	free	free	ADJ
admet-1845	140	33	radicals	radical	NOUN
admet-1845	140	34	to	to	PART
admet-1845	140	35	kill	kill	VERB
admet-1845	140	36	cells	cell	NOUN
admet-1845	140	37	.	.	PUNCT
admet-1845	141	1	therefore	therefore	ADV
admet-1845	141	2	,	,	PUNCT
admet-1845	141	3	rnpn	rnpn	VERB
admet-1845	141	4	with	with	ADP
admet-1845	141	5	tempol	tempol	NOUN
admet-1845	141	6	,	,	PUNCT
admet-1845	141	7	a	a	DET
admet-1845	141	8	ros	ros	PROPN
admet-1845	141	9	scavenger	scavenger	NOUN
admet-1845	141	10	in	in	ADP
admet-1845	141	11	the	the	DET
admet-1845	141	12	hydrophobic	hydrophobic	NOUN
admet-1845	141	13	core	core	NOUN
admet-1845	141	14	,	,	PUNCT
admet-1845	141	15	was	be	AUX
admet-1845	141	16	used	use	VERB
admet-1845	141	17	to	to	PART
admet-1845	141	18	encapsulate	encapsulate	VERB
admet-1845	141	19	dox	dox	NOUN
admet-1845	141	20	to	to	PART
admet-1845	141	21	reduce	reduce	VERB
admet-1845	141	22	its	its	PRON
admet-1845	141	23	side	side	NOUN
admet-1845	141	24	effects	effect	NOUN
admet-1845	141	25	in	in	ADP
admet-1845	141	26	an	an	DET
admet-1845	141	27	in	in	ADP
admet-1845	141	28	vitro	vitro	X
admet-1845	141	29	model	model	NOUN
admet-1845	141	30	.	.	PUNCT
admet-1845	142	1	as	as	SCONJ
admet-1845	142	2	shown	show	VERB
admet-1845	142	3	in	in	ADP
admet-1845	142	4	figure	figure	NOUN
admet-1845	142	5	5a	5a	NUM
admet-1845	142	6	,	,	PUNCT
admet-1845	142	7	dox	dox	NOUN
admet-1845	142	8	indicated	indicate	VERB
admet-1845	142	9	dose	dose	NOUN
admet-1845	142	10	-	-	PUNCT
admet-1845	142	11	dependence	dependence	NOUN
admet-1845	142	12	,	,	PUNCT
admet-1845	142	13	with	with	ADP
admet-1845	142	14	approximately	approximately	ADV
admet-1845	142	15	50	50	NUM
admet-1845	142	16	%	%	NOUN
admet-1845	142	17	of	of	ADP
admet-1845	142	18	l929	l929	PROPN
admet-1845	142	19	cell	cell	NOUN
admet-1845	142	20	death	death	NOUN
admet-1845	142	21	at	at	ADP
admet-1845	142	22	a	a	DET
admet-1845	142	23	concentration	concentration	NOUN
admet-1845	142	24	of	of	ADP
admet-1845	142	25	5	5	NUM
admet-1845	142	26	µg	µg	ADV
admet-1845	142	27	/	/	SYM
admet-1845	142	28	ml	ml	NOUN
admet-1845	142	29	dox	dox	NOUN
admet-1845	142	30	,	,	PUNCT
admet-1845	142	31	while	while	SCONJ
admet-1845	142	32	the	the	DET
admet-1845	142	33	nps	nps	PROPN
admet-1845	142	34	significantly	significantly	ADV
admet-1845	142	35	enhanced	enhance	VERB
admet-1845	142	36	cell	cell	NOUN
admet-1845	142	37	viability	viability	NOUN
admet-1845	142	38	,	,	PUNCT
admet-1845	142	39	almost	almost	ADV
admet-1845	142	40	equal	equal	ADJ
admet-1845	142	41	to	to	ADP
admet-1845	142	42	the	the	DET
admet-1845	142	43	control	control	NOUN
admet-1845	142	44	sample	sample	NOUN
admet-1845	142	45	.	.	PUNCT
admet-1845	143	1	despite	despite	SCONJ
admet-1845	143	2	dose	dose	NOUN
admet-1845	143	3	-	-	PUNCT
admet-1845	143	4	dependent	dependent	ADJ
admet-1845	143	5	toxicity	toxicity	NOUN
admet-1845	143	6	observed	observe	VERB
admet-1845	143	7	in	in	ADP
admet-1845	143	8	dox@rnpn	dox@rnpn	NOUN
admet-1845	143	9	and	and	CCONJ
admet-1845	143	10	dox@sirnp	dox@sirnp	PROPN
admet-1845	143	11	,	,	PUNCT
admet-1845	143	12	there	there	PRON
admet-1845	143	13	was	be	VERB
admet-1845	143	14	more	more	ADJ
admet-1845	143	15	than	than	ADP
admet-1845	143	16	90	90	NUM
admet-1845	143	17	%	%	NOUN
admet-1845	143	18	of	of	ADP
admet-1845	143	19	cell	cell	NOUN
admet-1845	143	20	viability	viability	NOUN
admet-1845	143	21	after	after	ADP
admet-1845	143	22	24	24	NUM
admet-1845	143	23	h	h	NOUN
admet-1845	143	24	of	of	ADP
admet-1845	143	25	incubation	incubation	NOUN
admet-1845	143	26	due	due	ADP
admet-1845	143	27	to	to	ADP
admet-1845	143	28	the	the	DET
admet-1845	143	29	scavenging	scavenge	VERB
admet-1845	143	30	ability	ability	NOUN
admet-1845	143	31	of	of	ADP
admet-1845	143	32	tempo	tempo	NOUN
admet-1845	143	33	groups	group	NOUN
admet-1845	143	34	.	.	PUNCT
admet-1845	144	1	in	in	ADP
admet-1845	144	2	addition	addition	NOUN
admet-1845	144	3	,	,	PUNCT
admet-1845	144	4	silica	silica	NOUN
admet-1845	144	5	nps	nps	PROPN
admet-1845	144	6	have	have	AUX
admet-1845	144	7	been	be	AUX
admet-1845	144	8	reported	report	VERB
admet-1845	144	9	to	to	PART
admet-1845	144	10	cause	cause	VERB
admet-1845	144	11	cytotoxicity	cytotoxicity	NOUN
admet-1845	144	12	due	due	ADP
admet-1845	144	13	to	to	ADP
admet-1845	144	14	the	the	DET
admet-1845	144	15	overproduction	overproduction	NOUN
admet-1845	144	16	of	of	ADP
admet-1845	144	17	ros	ros	PROPN
admet-1845	144	18	[	[	X
admet-1845	144	19	34	34	NUM
admet-1845	144	20	]	]	PUNCT
admet-1845	144	21	,	,	PUNCT
admet-1845	144	22	leading	lead	VERB
admet-1845	144	23	to	to	ADP
admet-1845	144	24	lower	low	ADJ
admet-1845	144	25	cell	cell	NOUN
admet-1845	144	26	viability	viability	NOUN
admet-1845	144	27	of	of	ADP
admet-1845	144	28	sirnp	sirnp	PROPN
admet-1845	144	29	compared	compare	VERB
admet-1845	144	30	to	to	PART
admet-1845	144	31	rnpn	rnpn	VERB
admet-1845	144	32	.	.	PUNCT
admet-1845	145	1	however	however	ADV
admet-1845	145	2	,	,	PUNCT
admet-1845	145	3	sirnp	sirnp	PROPN
admet-1845	145	4	treatment	treatment	NOUN
admet-1845	145	5	exhibited	exhibit	VERB
admet-1845	145	6	more	more	ADJ
admet-1845	145	7	than	than	ADP
admet-1845	145	8	90	90	NUM
admet-1845	145	9	%	%	NOUN
admet-1845	145	10	of	of	ADP
admet-1845	145	11	cell	cell	NOUN
admet-1845	145	12	viability	viability	NOUN
admet-1845	145	13	,	,	PUNCT
admet-1845	145	14	suggesting	suggest	VERB
admet-1845	145	15	the	the	DET
admet-1845	145	16	biosafe	biosafe	ADJ
admet-1845	145	17	profile	profile	NOUN
admet-1845	145	18	of	of	ADP
admet-1845	145	19	nps	nps	PROPN
admet-1845	145	20	.	.	PUNCT
admet-1845	146	1	similarly	similarly	ADV
admet-1845	146	2	,	,	PUNCT
admet-1845	146	3	anticancer	anticancer	NOUN
admet-1845	146	4	effects	effect	NOUN
admet-1845	146	5	of	of	ADP
admet-1845	146	6	dox	dox	NOUN
admet-1845	146	7	were	be	AUX
admet-1845	146	8	observed	observe	VERB
admet-1845	146	9	on	on	ADP
admet-1845	146	10	human	human	ADJ
admet-1845	146	11	breast	breast	NOUN
admet-1845	146	12	cancer	cancer	NOUN
admet-1845	146	13	cells	cell	NOUN
admet-1845	146	14	(	(	PUNCT
admet-1845	146	15	mcf-7	mcf-7	NOUN
admet-1845	146	16	)	)	PUNCT
admet-1845	146	17	and	and	CCONJ
admet-1845	146	18	human	human	ADJ
admet-1845	146	19	hepatocellular	hepatocellular	ADJ
admet-1845	146	20	carcinoma	carcinoma	NOUN
admet-1845	146	21	cells	cell	NOUN
admet-1845	146	22	(	(	PUNCT
admet-1845	146	23	hepg2	hepg2	NOUN
admet-1845	146	24	)	)	PUNCT
admet-1845	146	25	,	,	PUNCT
admet-1845	146	26	with	with	ADP
admet-1845	146	27	dose	dose	NOUN
admet-1845	146	28	dependence	dependence	NOUN
admet-1845	146	29	(	(	PUNCT
admet-1845	146	30	figure	figure	NOUN
admet-1845	146	31	5b	5b	NUM
admet-1845	146	32	and	and	CCONJ
admet-1845	146	33	figure	figure	VERB
admet-1845	146	34	5c	5c	NUM
admet-1845	146	35	)	)	PUNCT
admet-1845	146	36	.	.	PUNCT
admet-1845	147	1	remarkably	remarkably	ADV
admet-1845	147	2	,	,	PUNCT
admet-1845	147	3	dox@sirnp	dox@sirnp	PROPN
admet-1845	147	4	caused	cause	VERB
admet-1845	147	5	fewer	few	ADJ
admet-1845	147	6	cell	cell	NOUN
admet-1845	147	7	deaths	death	NOUN
admet-1845	147	8	(	(	PUNCT
admet-1845	147	9	around	around	ADV
admet-1845	147	10	20	20	NUM
admet-1845	147	11	and	and	CCONJ
admet-1845	147	12	25	25	NUM
admet-1845	147	13	%	%	NOUN
admet-1845	147	14	)	)	PUNCT
admet-1845	147	15	compared	compare	VERB
admet-1845	147	16	to	to	ADP
admet-1845	147	17	(	(	PUNCT
admet-1845	147	18	27	27	NUM
admet-1845	147	19	and	and	CCONJ
admet-1845	147	20	32	32	NUM
admet-1845	147	21	%	%	NOUN
admet-1845	147	22	)	)	PUNCT
admet-1845	147	23	at	at	ADP
admet-1845	147	24	5	5	NUM
admet-1845	147	25	µg	µg	ADV
admet-1845	147	26	/	/	SYM
admet-1845	147	27	ml	ml	NOUN
admet-1845	147	28	of	of	ADP
admet-1845	147	29	free	free	ADJ
admet-1845	147	30	dox	dox	NOUN
admet-1845	147	31	treatment	treatment	NOUN
admet-1845	147	32	against	against	ADP
admet-1845	147	33	mcf-7	mcf-7	NOUN
admet-1845	147	34	and	and	CCONJ
admet-1845	147	35	hepg2	hepg2	PROPN
admet-1845	147	36	,	,	PUNCT
admet-1845	147	37	respectively	respectively	ADV
admet-1845	147	38	.	.	PUNCT
admet-1845	148	1	this	this	DET
admet-1845	148	2	result	result	NOUN
admet-1845	148	3	may	may	AUX
admet-1845	148	4	be	be	AUX
admet-1845	148	5	due	due	ADJ
admet-1845	148	6	to	to	ADP
admet-1845	148	7	dox	dox	NOUN
admet-1845	148	8	being	be	AUX
admet-1845	148	9	kept	keep	VERB
admet-1845	148	10	inside	inside	ADP
admet-1845	148	11	the	the	DET
admet-1845	148	12	core	core	NOUN
admet-1845	148	13	of	of	ADP
admet-1845	148	14	sirnp	sirnp	PROPN
admet-1845	148	15	,	,	PUNCT
admet-1845	148	16	resulting	result	VERB
admet-1845	148	17	in	in	ADP
admet-1845	148	18	less	less	ADJ
admet-1845	148	19	exposure	exposure	NOUN
admet-1845	148	20	to	to	ADP
admet-1845	148	21	cells	cell	NOUN
admet-1845	148	22	,	,	PUNCT
admet-1845	148	23	although	although	SCONJ
admet-1845	148	24	encapsulation	encapsulation	NOUN
admet-1845	148	25	of	of	ADP
admet-1845	148	26	dox	dox	NOUN
admet-1845	148	27	in	in	ADP
admet-1845	148	28	nps	nps	PROPN
admet-1845	148	29	was	be	AUX
admet-1845	148	30	expected	expect	VERB
admet-1845	148	31	to	to	PART
admet-1845	148	32	be	be	AUX
admet-1845	148	33	more	more	ADV
admet-1845	148	34	effective	effective	ADJ
admet-1845	148	35	at	at	ADP
admet-1845	148	36	entering	enter	VERB
admet-1845	148	37	cells	cell	NOUN
admet-1845	148	38	.	.	PUNCT
admet-1845	149	1	in	in	ADP
admet-1845	149	2	contrast	contrast	NOUN
admet-1845	149	3	,	,	PUNCT
admet-1845	149	4	the	the	DET
admet-1845	149	5	anticancer	anticancer	NOUN
admet-1845	149	6	effect	effect	NOUN
admet-1845	149	7	caused	cause	VERB
admet-1845	149	8	by	by	ADP
admet-1845	149	9	dox@rnpn	dox@rnpn	NOUN
admet-1845	149	10	(	(	PUNCT
admet-1845	149	11	5	5	NUM
admet-1845	149	12	µg	µg	NOUN
admet-1845	149	13	/	/	SYM
admet-1845	149	14	ml	ml	NOUN
admet-1845	149	15	of	of	ADP
admet-1845	149	16	dox	dox	NOUN
admet-1845	149	17	)	)	PUNCT
admet-1845	149	18	was	be	AUX
admet-1845	149	19	36	36	NUM
admet-1845	149	20	and	and	CCONJ
admet-1845	149	21	37	37	NUM
admet-1845	149	22	%	%	NOUN
admet-1845	149	23	for	for	ADP
admet-1845	149	24	mcf-7	mcf-7	NOUN
admet-1845	149	25	and	and	CCONJ
admet-1845	149	26	hepg2	hepg2	PROPN
admet-1845	149	27	,	,	PUNCT
admet-1845	149	28	respectively	respectively	ADV
admet-1845	149	29	.	.	PUNCT
admet-1845	150	1	it	it	PRON
admet-1845	150	2	is	be	AUX
admet-1845	150	3	obvious	obvious	ADJ
admet-1845	150	4	that	that	SCONJ
admet-1845	150	5	the	the	DET
admet-1845	150	6	cumulative	cumulative	ADJ
admet-1845	150	7	release	release	NOUN
admet-1845	150	8	of	of	ADP
admet-1845	150	9	dox@rnpn	dox@rnpn	NOUN
admet-1845	150	10	was	be	AUX
admet-1845	150	11	faster	fast	ADJ
admet-1845	150	12	as	as	SCONJ
admet-1845	150	13	compared	compare	VERB
admet-1845	150	14	to	to	ADP
admet-1845	150	15	dox@sirnp	dox@sirnp	PROPN
admet-1845	150	16	,	,	PUNCT
admet-1845	150	17	resulting	result	VERB
admet-1845	150	18	in	in	ADP
admet-1845	150	19	higher	high	ADJ
admet-1845	150	20	cytotoxicity	cytotoxicity	NOUN
admet-1845	150	21	when	when	SCONJ
admet-1845	150	22	entering	enter	VERB
admet-1845	150	23	cells	cell	NOUN
admet-1845	150	24	.	.	PUNCT
admet-1845	151	1	https://doi.org/10.5599/admet.1845	https://doi.org/10.5599/admet.1845	ADP
admet-1845	151	2	m.-d	m.-d	PROPN
admet-1845	151	3	.	.	PUNCT
admet-1845	152	1	quoc	quoc	PROPN
admet-1845	152	2	tang	tang	INTJ
admet-1845	152	3	et	et	PROPN
admet-1845	152	4	al	al	PROPN
admet-1845	152	5	.	.	PROPN
admet-1845	152	6	admet	admet	PROPN
admet-1845	152	7	&	&	CCONJ
admet-1845	152	8	dmpk	dmpk	PROPN
admet-1845	152	9	11(4	11(4	NUM
admet-1845	152	10	)	)	PUNCT
admet-1845	152	11	(	(	PUNCT
admet-1845	152	12	2023	2023	NUM
admet-1845	152	13	)	)	PUNCT
admet-1845	152	14	551	551	NUM
admet-1845	152	15	-	-	SYM
admet-1845	152	16	560	560	NUM
admet-1845	152	17	558	558	NUM
admet-1845	152	18	figure	figure	NOUN
admet-1845	152	19	5	5	NUM
admet-1845	152	20	.	.	PUNCT
admet-1845	153	1	the	the	DET
admet-1845	153	2	cytotoxicity	cytotoxicity	NOUN
admet-1845	153	3	on	on	ADP
admet-1845	153	4	various	various	ADJ
admet-1845	153	5	cells	cell	NOUN
admet-1845	153	6	.	.	PUNCT
admet-1845	154	1	the	the	DET
admet-1845	154	2	cell	cell	NOUN
admet-1845	154	3	viability	viability	NOUN
admet-1845	154	4	was	be	AUX
admet-1845	154	5	measured	measure	VERB
admet-1845	154	6	by	by	ADP
admet-1845	154	7	mtt	mtt	PROPN
admet-1845	154	8	assay	assay	NOUN
admet-1845	154	9	.	.	PUNCT
admet-1845	155	1	(	(	PUNCT
admet-1845	155	2	a	a	X
admet-1845	155	3	)	)	PUNCT
admet-1845	155	4	murine	murine	ADJ
admet-1845	155	5	fibroblast	fibroblast	ADJ
admet-1845	155	6	cells	cell	NOUN
admet-1845	155	7	(	(	PUNCT
admet-1845	155	8	l929	l929	PROPN
admet-1845	155	9	)	)	PUNCT
admet-1845	155	10	.	.	PUNCT
admet-1845	156	1	(	(	PUNCT
admet-1845	156	2	b	b	X
admet-1845	156	3	)	)	PUNCT
admet-1845	156	4	human	human	ADJ
admet-1845	156	5	breast	breast	NOUN
admet-1845	156	6	cancer	cancer	NOUN
admet-1845	156	7	cells	cell	NOUN
admet-1845	156	8	(	(	PUNCT
admet-1845	156	9	mcf-7	mcf-7	NOUN
admet-1845	156	10	)	)	PUNCT
admet-1845	156	11	.	.	PUNCT
admet-1845	157	1	(	(	PUNCT
admet-1845	157	2	c	c	X
admet-1845	157	3	)	)	PUNCT
admet-1845	157	4	human	human	ADJ
admet-1845	157	5	hepatocellular	hepatocellular	ADJ
admet-1845	157	6	carcinoma	carcinoma	NOUN
admet-1845	157	7	cells	cell	NOUN
admet-1845	157	8	(	(	PUNCT
admet-1845	157	9	hepg2	hepg2	NOUN
admet-1845	157	10	)	)	PUNCT
admet-1845	157	11	.	.	PUNCT
admet-1845	158	1	data	datum	NOUN
admet-1845	158	2	were	be	AUX
admet-1845	158	3	presented	present	VERB
admet-1845	158	4	as	as	ADP
admet-1845	158	5	the	the	DET
admet-1845	158	6	mean	mean	PROPN
admet-1845	158	7	±	±	NUM
admet-1845	158	8	standard	standard	ADJ
admet-1845	158	9	deviation	deviation	NOUN
admet-1845	158	10	(	(	PUNCT
admet-1845	158	11	sd	sd	NOUN
admet-1845	158	12	)	)	PUNCT
admet-1845	158	13	;	;	PUNCT
admet-1845	158	14	n	n	CCONJ
admet-1845	158	15	=3	=3	VERB
admet-1845	158	16	;	;	PUNCT
admet-1845	158	17	p	p	X
admet-1845	158	18	<	<	X
admet-1845	158	19	0.05	0.05	NUM
admet-1845	158	20	(	(	PUNCT
admet-1845	158	21	*	*	NOUN
admet-1845	158	22	)	)	PUNCT
admet-1845	158	23	.	.	PUNCT
admet-1845	159	1	conclusions	conclusion	NOUN
admet-1845	159	2	in	in	ADP
admet-1845	159	3	this	this	DET
admet-1845	159	4	study	study	NOUN
admet-1845	159	5	,	,	PUNCT
admet-1845	159	6	non	non	ADJ
admet-1845	159	7	-	-	NOUN
admet-1845	159	8	silica	silica	NOUN
admet-1845	159	9	and	and	CCONJ
admet-1845	159	10	silica	silica	NOUN
admet-1845	159	11	redox	redox	PROPN
admet-1845	159	12	nps	nps	PROPN
admet-1845	159	13	(	(	PUNCT
admet-1845	159	14	rnpn	rnpn	NOUN
admet-1845	159	15	and	and	CCONJ
admet-1845	159	16	sirnp	sirnp	PROPN
admet-1845	159	17	,	,	PUNCT
admet-1845	159	18	respectively	respectively	ADV
admet-1845	159	19	)	)	PUNCT
admet-1845	159	20	with	with	ADP
admet-1845	159	21	ros	ros	PROPN
admet-1845	159	22	scavenging	scavenging	NOUN
admet-1845	159	23	moieties	moiety	NOUN
admet-1845	159	24	on	on	ADP
admet-1845	159	25	hydrophobic	hydrophobic	NOUN
admet-1845	159	26	side	side	NOUN
admet-1845	159	27	chains	chain	NOUN
admet-1845	159	28	were	be	AUX
admet-1845	159	29	prepared	prepare	VERB
admet-1845	159	30	to	to	PART
admet-1845	159	31	encapsulate	encapsulate	VERB
admet-1845	159	32	dox	dox	NOUN
admet-1845	159	33	to	to	PART
admet-1845	159	34	reduce	reduce	VERB
admet-1845	159	35	its	its	PRON
admet-1845	159	36	adverse	adverse	ADJ
admet-1845	159	37	effects	effect	NOUN
admet-1845	159	38	.	.	PUNCT
admet-1845	160	1	the	the	DET
admet-1845	160	2	dox@rnpn	dox@rnpn	NOUN
admet-1845	160	3	and	and	CCONJ
admet-1845	160	4	dox@sirnp	dox@sirnp	PROPN
admet-1845	160	5	were	be	AUX
admet-1845	160	6	successfully	successfully	ADV
admet-1845	160	7	prepared	prepare	VERB
admet-1845	160	8	with	with	ADP
admet-1845	160	9	several	several	ADJ
admet-1845	160	10	tens	ten	NOUN
admet-1845	160	11	nm	nm	PRON
admet-1845	160	12	distributions	distribution	NOUN
admet-1845	160	13	and	and	CCONJ
admet-1845	160	14	stable	stable	ADJ
admet-1845	160	15	dispersion	dispersion	NOUN
admet-1845	160	16	.	.	PUNCT
admet-1845	161	1	the	the	DET
admet-1845	161	2	obtained	obtain	VERB
admet-1845	161	3	results	result	NOUN
admet-1845	161	4	indicated	indicate	VERB
admet-1845	161	5	that	that	SCONJ
admet-1845	161	6	the	the	DET
admet-1845	161	7	addition	addition	NOUN
admet-1845	161	8	of	of	ADP
admet-1845	161	9	silanol	silanol	NOUN
admet-1845	161	10	groups	group	NOUN
admet-1845	161	11	significantly	significantly	ADV
admet-1845	161	12	improved	improve	VERB
admet-1845	161	13	the	the	DET
admet-1845	161	14	stability	stability	NOUN
admet-1845	161	15	of	of	ADP
admet-1845	161	16	rnpn	rnpn	NOUN
admet-1845	161	17	in	in	ADP
admet-1845	161	18	acidic	acidic	ADJ
admet-1845	161	19	ph	ph	NOUN
admet-1845	161	20	and	and	CCONJ
admet-1845	161	21	the	the	DET
admet-1845	161	22	encapsulation	encapsulation	NOUN
admet-1845	161	23	efficacy	efficacy	NOUN
admet-1845	161	24	of	of	ADP
admet-1845	161	25	dox	dox	NOUN
admet-1845	161	26	into	into	ADP
admet-1845	161	27	sirnp	sirnp	PROPN
admet-1845	161	28	.	.	PUNCT
admet-1845	162	1	due	due	ADP
admet-1845	162	2	to	to	ADP
admet-1845	162	3	its	its	PRON
admet-1845	162	4	ph	ph	ADJ
admet-1845	162	5	-	-	ADJ
admet-1845	162	6	sensitive	sensitive	ADJ
admet-1845	162	7	character	character	NOUN
admet-1845	162	8	,	,	PUNCT
admet-1845	162	9	dox@rnpn	dox@rnpn	PROPN
admet-1845	162	10	exhibited	exhibit	VERB
admet-1845	162	11	a	a	DET
admet-1845	162	12	faster	fast	ADJ
admet-1845	162	13	release	release	NOUN
admet-1845	162	14	of	of	ADP
admet-1845	162	15	dox	dox	NOUN
admet-1845	162	16	under	under	ADP
admet-1845	162	17	acidic	acidic	ADJ
admet-1845	162	18	ph	ph	ADJ
admet-1845	162	19	environments	environment	NOUN
admet-1845	162	20	as	as	SCONJ
admet-1845	162	21	compared	compare	VERB
admet-1845	162	22	to	to	ADP
admet-1845	162	23	dox@sirnp	dox@sirnp	PROPN
admet-1845	162	24	.	.	PUNCT
admet-1845	163	1	both	both	PRON
admet-1845	163	2	dox@rnpn	dox@rnpn	PROPN
admet-1845	163	3	and	and	CCONJ
admet-1845	163	4	dox@sirnp	dox@sirnp	PROPN
admet-1845	163	5	suppressed	suppress	VERB
admet-1845	163	6	the	the	DET
admet-1845	163	7	cytotoxicity	cytotoxicity	NOUN
admet-1845	163	8	of	of	ADP
admet-1845	163	9	dox	dox	NOUN
admet-1845	163	10	against	against	ADP
admet-1845	163	11	normal	normal	ADJ
admet-1845	163	12	fibroblast	fibroblast	ADJ
admet-1845	163	13	cells	cell	NOUN
admet-1845	163	14	while	while	SCONJ
admet-1845	163	15	they	they	PRON
admet-1845	163	16	exhibited	exhibit	VERB
admet-1845	163	17	the	the	DET
admet-1845	163	18	anticancer	anticancer	NOUN
admet-1845	163	19	activity	activity	NOUN
admet-1845	163	20	to	to	PART
admet-1845	163	21	induce	induce	VERB
admet-1845	163	22	cell	cell	NOUN
admet-1845	163	23	death	death	NOUN
admet-1845	163	24	in	in	ADP
admet-1845	163	25	liver	liver	NOUN
admet-1845	163	26	cancer	cancer	NOUN
admet-1845	163	27	and	and	CCONJ
admet-1845	163	28	breast	breast	NOUN
admet-1845	163	29	cancer	cancer	NOUN
admet-1845	163	30	cell	cell	NOUN
admet-1845	163	31	lines	line	NOUN
admet-1845	163	32	.	.	PUNCT
admet-1845	164	1	therefore	therefore	ADV
admet-1845	164	2	,	,	PUNCT
admet-1845	164	3	dox@rnpn	dox@rnpn	PROPN
admet-1845	164	4	and	and	CCONJ
admet-1845	164	5	dox@sirnp	dox@sirnp	PROPN
admet-1845	164	6	could	could	AUX
admet-1845	164	7	be	be	AUX
admet-1845	164	8	considered	consider	VERB
admet-1845	164	9	potential	potential	ADJ
admet-1845	164	10	nanomedicines	nanomedicine	NOUN
admet-1845	164	11	for	for	ADP
admet-1845	164	12	cancer	cancer	NOUN
admet-1845	164	13	treatments	treatment	NOUN
admet-1845	164	14	.	.	PUNCT
admet-1845	165	1	conflict	conflict	NOUN
admet-1845	165	2	of	of	ADP
admet-1845	165	3	interest	interest	NOUN
admet-1845	165	4	:	:	PUNCT
admet-1845	165	5	the	the	DET
admet-1845	165	6	authors	author	NOUN
admet-1845	165	7	have	have	VERB
admet-1845	165	8	no	no	DET
admet-1845	165	9	conflicts	conflict	NOUN
admet-1845	165	10	of	of	ADP
admet-1845	165	11	interest	interest	NOUN
admet-1845	165	12	to	to	PART
admet-1845	165	13	declare	declare	VERB
admet-1845	165	14	.	.	PUNCT
admet-1845	166	1	acknowledgements	acknowledgement	NOUN
admet-1845	166	2	:	:	PUNCT
admet-1845	166	3	this	this	DET
admet-1845	166	4	work	work	NOUN
admet-1845	166	5	was	be	AUX
admet-1845	166	6	supported	support	VERB
admet-1845	166	7	by	by	ADP
admet-1845	166	8	vietnam	vietnam	PROPN
admet-1845	166	9	national	national	PROPN
admet-1845	166	10	university	university	PROPN
admet-1845	166	11	ho	ho	PROPN
admet-1845	166	12	chi	chi	PROPN
admet-1845	166	13	minh	minh	PROPN
admet-1845	166	14	city	city	NOUN
admet-1845	166	15	(	(	PUNCT
admet-1845	166	16	vnu	vnu	PROPN
admet-1845	166	17	-	-	PUNCT
admet-1845	166	18	hcm	hcm	NOUN
admet-1845	166	19	)	)	PUNCT
admet-1845	166	20	under	under	ADP
admet-1845	166	21	grant	grant	NOUN
admet-1845	166	22	numbers	number	NOUN
admet-1845	166	23	ncm2020	ncm2020	NOUN
admet-1845	166	24	-	-	PUNCT
admet-1845	166	25	28	28	NUM
admet-1845	166	26	-	-	SYM
admet-1845	166	27	01	01	NUM
admet-1845	166	28	.	.	PUNCT
admet-1845	167	1	authors	author	NOUN
admet-1845	167	2	would	would	AUX
admet-1845	167	3	like	like	VERB
admet-1845	167	4	to	to	PART
admet-1845	167	5	thank	thank	VERB
admet-1845	167	6	prof	prof	PROPN
admet-1845	167	7	.	.	PUNCT
admet-1845	168	1	nagasaki	nagasaki	PROPN
admet-1845	168	2	yukio	yukio	PROPN
admet-1845	168	3	(	(	PUNCT
admet-1845	168	4	university	university	PROPN
admet-1845	168	5	of	of	ADP
admet-1845	168	6	tsukuba	tsukuba	PROPN
admet-1845	168	7	,	,	PUNCT
admet-1845	168	8	japan	japan	PROPN
admet-1845	168	9	)	)	PUNCT
admet-1845	168	10	for	for	ADP
admet-1845	168	11	kindly	kindly	ADV
admet-1845	168	12	sharing	share	VERB
admet-1845	168	13	the	the	DET
admet-1845	168	14	polymers	polymer	NOUN
admet-1845	168	15	used	use	VERB
admet-1845	168	16	in	in	ADP
admet-1845	168	17	this	this	DET
admet-1845	168	18	study	study	NOUN
admet-1845	168	19	.	.	PUNCT
admet-1845	169	1	references	reference	NOUN
admet-1845	169	2	[	[	X
admet-1845	169	3	1	1	X
admet-1845	169	4	]	]	PUNCT
admet-1845	169	5	j.	j.	PROPN
admet-1845	169	6	sun	sun	PROPN
admet-1845	169	7	,	,	PUNCT
admet-1845	169	8	q.	q.	PROPN
admet-1845	169	9	wei	wei	PROPN
admet-1845	169	10	,	,	PUNCT
admet-1845	169	11	y.	y.	PROPN
admet-1845	169	12	zhou	zhou	PROPN
admet-1845	169	13	,	,	PUNCT
admet-1845	169	14	j.	j.	PROPN
admet-1845	169	15	wang	wang	PROPN
admet-1845	169	16	,	,	PUNCT
admet-1845	169	17	q.	q.	PROPN
admet-1845	169	18	liu	liu	PROPN
admet-1845	169	19	,	,	PUNCT
admet-1845	169	20	h.	h.	PROPN
admet-1845	169	21	xu	xu	PROPN
admet-1845	169	22	.	.	PUNCT
admet-1845	170	1	a	a	DET
admet-1845	170	2	systematic	systematic	ADJ
admet-1845	170	3	analysis	analysis	NOUN
admet-1845	170	4	of	of	ADP
admet-1845	170	5	fda	fda	PROPN
admet-1845	170	6	-	-	PUNCT
admet-1845	170	7	approved	approve	VERB
admet-1845	170	8	anticancer	anticancer	NOUN
admet-1845	170	9	drugs	drug	NOUN
admet-1845	170	10	.	.	PUNCT
admet-1845	171	1	bmc	bmc	NOUN
admet-1845	171	2	systems	system	NOUN
admet-1845	171	3	biology	biology	NOUN
admet-1845	171	4	11	11	NUM
admet-1845	171	5	(	(	PUNCT
admet-1845	171	6	2017	2017	NUM
admet-1845	171	7	)	)	PUNCT
admet-1845	171	8	1	1	NUM
admet-1845	171	9	-	-	SYM
admet-1845	171	10	17	17	NUM
admet-1845	171	11	.	.	PUNCT
admet-1845	172	1	https://doi.org/10.1186/s12918-017-0464-7	https://doi.org/10.1186/s12918-017-0464-7	X
admet-1845	173	1	[	[	X
admet-1845	173	2	2	2	NUM
admet-1845	173	3	]	]	PUNCT
admet-1845	173	4	l.	l.	PROPN
admet-1845	173	5	gianni	gianni	PROPN
admet-1845	173	6	,	,	PUNCT
admet-1845	173	7	j.l	j.l	PROPN
admet-1845	173	8	.	.	PROPN
admet-1845	173	9	zweier	zweier	PROPN
admet-1845	173	10	,	,	PUNCT
admet-1845	173	11	a.	a.	NOUN
admet-1845	173	12	levy	levy	NOUN
admet-1845	173	13	,	,	PUNCT
admet-1845	173	14	c.	c.	PROPN
admet-1845	173	15	myers	myers	PROPN
admet-1845	173	16	.	.	PUNCT
admet-1845	174	1	characterization	characterization	NOUN
admet-1845	174	2	of	of	ADP
admet-1845	174	3	the	the	DET
admet-1845	174	4	cycle	cycle	NOUN
admet-1845	174	5	of	of	ADP
admet-1845	174	6	iron	iron	NOUN
admet-1845	174	7	-	-	PUNCT
admet-1845	174	8	mediated	mediate	VERB
admet-1845	174	9	electron	electron	NOUN
admet-1845	174	10	transfer	transfer	NOUN
admet-1845	174	11	from	from	ADP
admet-1845	174	12	adriamycin	adriamycin	PRON
admet-1845	174	13	to	to	ADP
admet-1845	174	14	molecular	molecular	ADJ
admet-1845	174	15	oxygen	oxygen	NOUN
admet-1845	174	16	.	.	PUNCT
admet-1845	175	1	journal	journal	NOUN
admet-1845	175	2	of	of	ADP
admet-1845	175	3	biological	biological	ADJ
admet-1845	175	4	chemistry	chemistry	NOUN
admet-1845	175	5	260	260	NUM
admet-1845	175	6	(	(	PUNCT
admet-1845	175	7	1985	1985	NUM
admet-1845	175	8	)	)	PUNCT
admet-1845	175	9	6820	6820	NUM
admet-1845	175	10	-	-	SYM
admet-1845	175	11	6826	6826	NUM
admet-1845	175	12	.	.	PUNCT
admet-1845	176	1	https://doi.org/10.1016/s0021-9258(18)88854-8	https://doi.org/10.1016/s0021-9258(18)88854-8	NOUN
admet-1845	177	1	[	[	X
admet-1845	177	2	3	3	NUM
admet-1845	177	3	]	]	X
admet-1845	177	4	r.d	r.d	PROPN
admet-1845	177	5	.	.	PROPN
admet-1845	177	6	olson	olson	PROPN
admet-1845	177	7	,	,	PUNCT
admet-1845	177	8	p.s	p.s	PROPN
admet-1845	177	9	.	.	PUNCT
admet-1845	178	1	mushlin	mushlin	PROPN
admet-1845	178	2	.	.	PUNCT
admet-1845	179	1	doxorubicin	doxorubicin	PROPN
admet-1845	179	2	cardiotoxicity	cardiotoxicity	PROPN
admet-1845	179	3	:	:	PUNCT
admet-1845	179	4	analysis	analysis	NOUN
admet-1845	179	5	of	of	ADP
admet-1845	179	6	prevailing	prevail	VERB
admet-1845	179	7	hypotheses	hypothesis	NOUN
admet-1845	179	8	.	.	PUNCT
admet-1845	180	1	the	the	DET
admet-1845	180	2	faseb	faseb	PROPN
admet-1845	180	3	journal	journal	PROPN
admet-1845	180	4	4	4	NUM
admet-1845	180	5	(	(	PUNCT
admet-1845	180	6	1990	1990	NUM
admet-1845	180	7	)	)	PUNCT
admet-1845	180	8	3076	3076	NUM
admet-1845	180	9	-	-	SYM
admet-1845	180	10	3086	3086	NUM
admet-1845	180	11	.	.	PUNCT
admet-1845	181	1	https://doi.org/10.1096/fasebj.4.13.2210154	https://doi.org/10.1096/fasebj.4.13.2210154	NOUN
admet-1845	181	2	[	[	X
admet-1845	181	3	4	4	NUM
admet-1845	181	4	]	]	X
admet-1845	181	5	h.	h.	PROPN
admet-1845	181	6	keizer	keizer	PROPN
admet-1845	181	7	,	,	PUNCT
admet-1845	181	8	h.	h.	PROPN
admet-1845	181	9	pinedo	pinedo	PROPN
admet-1845	181	10	,	,	PUNCT
admet-1845	181	11	g.	g.	PROPN
admet-1845	181	12	schuurhuis	schuurhuis	PROPN
admet-1845	181	13	,	,	PUNCT
admet-1845	181	14	h.	h.	PROPN
admet-1845	181	15	joenje	joenje	PROPN
admet-1845	181	16	.	.	PUNCT
admet-1845	182	1	doxorubicin	doxorubicin	PROPN
admet-1845	182	2	(	(	PUNCT
admet-1845	182	3	adriamycin	adriamycin	PROPN
admet-1845	182	4	):	):	PUNCT
admet-1845	182	5	a	a	DET
admet-1845	182	6	critical	critical	ADJ
admet-1845	182	7	review	review	NOUN
admet-1845	182	8	of	of	ADP
admet-1845	182	9	free	free	ADJ
admet-1845	182	10	radicaldependent	radicaldependent	ADJ
admet-1845	182	11	mechanisms	mechanism	NOUN
admet-1845	182	12	of	of	ADP
admet-1845	182	13	cytotoxicity	cytotoxicity	NOUN
admet-1845	182	14	.	.	PUNCT
admet-1845	183	1	pharmacology	pharmacology	NOUN
admet-1845	183	2	&	&	CCONJ
admet-1845	183	3	therapeutics	therapeutic	NOUN
admet-1845	183	4	47	47	NUM
admet-1845	183	5	(	(	PUNCT
admet-1845	183	6	1990	1990	NUM
admet-1845	183	7	)	)	PUNCT
admet-1845	183	8	219	219	NUM
admet-1845	183	9	-	-	SYM
admet-1845	183	10	231	231	NUM
admet-1845	183	11	.	.	PUNCT
admet-1845	184	1	https://doi.org/	https://doi.org/	NOUN
admet-1845	184	2	10.1016/0163	10.1016/0163	NUM
admet-1845	184	3	-	-	PUNCT
admet-1845	184	4	7258(90)90088	7258(90)90088	NUM
admet-1845	184	5	-	-	PUNCT
admet-1845	184	6	j	j	NOUN
admet-1845	185	1	[	[	X
admet-1845	185	2	5	5	NUM
admet-1845	185	3	]	]	X
admet-1845	185	4	m.s	m.s	PROPN
admet-1845	185	5	.	.	PROPN
admet-1845	185	6	horenstein	horenstein	PROPN
admet-1845	185	7	,	,	PUNCT
admet-1845	185	8	r.s	r.s	PROPN
admet-1845	185	9	.	.	PROPN
admet-1845	185	10	vander	vander	PROPN
admet-1845	185	11	heide	heide	PROPN
admet-1845	185	12	,	,	PUNCT
admet-1845	185	13	t.j	t.j	PROPN
admet-1845	185	14	.	.	PROPN
admet-1845	185	15	l'ecuyer	l'ecuyer	PROPN
admet-1845	185	16	.	.	PUNCT
admet-1845	186	1	molecular	molecular	ADJ
admet-1845	186	2	basis	basis	NOUN
admet-1845	186	3	of	of	ADP
admet-1845	186	4	anthracycline	anthracycline	NOUN
admet-1845	186	5	-induced	-induce	VERB
admet-1845	186	6	cardio	cardio	NOUN
admet-1845	186	7	toxicity	toxicity	NOUN
admet-1845	186	8	and	and	CCONJ
admet-1845	186	9	its	its	PRON
admet-1845	186	10	prevention	prevention	NOUN
admet-1845	186	11	.	.	PUNCT
admet-1845	187	1	molecular	molecular	ADJ
admet-1845	187	2	genetics	genetic	NOUN
admet-1845	187	3	and	and	CCONJ
admet-1845	187	4	metabolism	metabolism	NOUN
admet-1845	187	5	71	71	NUM
admet-1845	187	6	(	(	PUNCT
admet-1845	187	7	2000	2000	NUM
admet-1845	187	8	)	)	PUNCT
admet-1845	187	9	436	436	NUM
admet-1845	187	10	-	-	SYM
admet-1845	187	11	444	444	NUM
admet-1845	187	12	.	.	PUNCT
admet-1845	188	1	https://doi.org/	https://doi.org/	NOUN
admet-1845	188	2	10.1006	10.1006	NUM
admet-1845	188	3	/	/	SYM
admet-1845	188	4	mgme.2000.3043	mgme.2000.3043	NOUN
admet-1845	189	1	[	[	X
admet-1845	189	2	6	6	NUM
admet-1845	189	3	]	]	X
admet-1845	189	4	a.g	a.g	PROPN
admet-1845	189	5	.	.	PROPN
admet-1845	189	6	patel	patel	PROPN
admet-1845	189	7	,	,	PUNCT
admet-1845	189	8	s.h	s.h	PROPN
admet-1845	189	9	.	.	PROPN
admet-1845	189	10	kaufmann	kaufmann	PROPN
admet-1845	189	11	.	.	PUNCT
admet-1845	190	1	how	how	SCONJ
admet-1845	190	2	does	do	AUX
admet-1845	190	3	doxorubicin	doxorubicin	PROPN
admet-1845	190	4	work	work	VERB
admet-1845	190	5	?	?	PUNCT
admet-1845	191	1	elife	elife	NOUN
admet-1845	191	2	1	1	NUM
admet-1845	191	3	(	(	PUNCT
admet-1845	191	4	2012	2012	NUM
admet-1845	191	5	)	)	PUNCT
admet-1845	191	6	e00387	e00387	PROPN
admet-1845	191	7	.	.	PUNCT
admet-1845	191	8	https://doi.org/	https://doi.org/	PROPN
admet-1845	191	9	10.7554	10.7554	NUM
admet-1845	191	10	/	/	SYM
admet-1845	192	1	elife.00387	elife.00387	PROPN
admet-1845	192	2	[	[	X
admet-1845	192	3	7	7	NUM
admet-1845	192	4	]	]	X
admet-1845	192	5	c.f	c.f	PROPN
admet-1845	192	6	.	.	PROPN
admet-1845	192	7	thorn	thorn	PROPN
admet-1845	192	8	,	,	PUNCT
admet-1845	192	9	c.	c.	PROPN
admet-1845	192	10	oshiro	oshiro	PROPN
admet-1845	192	11	,	,	PUNCT
admet-1845	192	12	s.	s.	PROPN
admet-1845	192	13	marsh	marsh	PROPN
admet-1845	192	14	,	,	PUNCT
admet-1845	192	15	t.	t.	PROPN
admet-1845	192	16	hernandez	hernandez	PROPN
admet-1845	192	17	-	-	PUNCT
admet-1845	192	18	boussard	boussard	PROPN
admet-1845	192	19	,	,	PUNCT
admet-1845	192	20	h.	h.	PROPN
admet-1845	192	21	mcleod	mcleod	PROPN
admet-1845	192	22	,	,	PUNCT
admet-1845	192	23	t.e	t.e	PROPN
admet-1845	192	24	.	.	PROPN
admet-1845	192	25	klein	klein	PROPN
admet-1845	192	26	,	,	PUNCT
admet-1845	192	27	r.b	r.b	PROPN
admet-1845	192	28	.	.	PROPN
admet-1845	192	29	altman	altman	PROPN
admet-1845	192	30	.	.	PUNCT
admet-1845	193	1	doxorubicin	doxorubicin	PROPN
admet-1845	193	2	pathways	pathway	NOUN
admet-1845	193	3	:	:	PUNCT
admet-1845	193	4	pharmacodynamics	pharmacodynamic	NOUN
admet-1845	193	5	and	and	CCONJ
admet-1845	193	6	adverse	adverse	ADJ
admet-1845	193	7	effects	effect	NOUN
admet-1845	193	8	.	.	PUNCT
admet-1845	194	1	pharmacogenetics	pharmacogenetic	NOUN
admet-1845	194	2	and	and	CCONJ
admet-1845	194	3	genomics	genomic	NOUN
admet-1845	194	4	21	21	NUM
admet-1845	194	5	(	(	PUNCT
admet-1845	194	6	2011	2011	NUM
admet-1845	194	7	)	)	PUNCT
admet-1845	194	8	440	440	NUM
admet-1845	194	9	.	.	PUNCT
admet-1845	194	10	https://doi.org/10.1097/fpc.0b013e32833ffb56	https://doi.org/10.1097/fpc.0b013e32833ffb56	VERB
admet-1845	194	11	https://doi.org/10.1186/s12918-017-0464-7	https://doi.org/10.1186/s12918-017-0464-7	PROPN
admet-1845	194	12	https://doi.org/10.1016/s0021-9258(18)88854-8	https://doi.org/10.1016/s0021-9258(18)88854-8	PROPN
admet-1845	194	13	https://doi.org/10.1096/fasebj.4.13.2210154	https://doi.org/10.1096/fasebj.4.13.2210154	VERB
admet-1845	194	14	https://doi.org/‌10.1016/0163-7258(90)90088-j	https://doi.org/‌10.1016/0163-7258(90)90088-j	PROPN
admet-1845	194	15	https://doi.org/‌10.1016/0163-7258(90)90088-j	https://doi.org/‌10.1016/0163-7258(90)90088-j	PROPN
admet-1845	194	16	https://doi.org/‌10.1006/mgme.2000.3043	https://doi.org/‌10.1006/mgme.2000.3043	PROPN
admet-1845	194	17	https://doi.org/‌10.1006/mgme.2000.3043	https://doi.org/‌10.1006/mgme.2000.3043	PROPN
admet-1845	194	18	https://doi.org/‌10.7554/elife.00387	https://doi.org/‌10.7554/elife.00387	NOUN
admet-1845	194	19	https://doi.org/‌10.7554/elife.00387	https://doi.org/‌10.7554/elife.00387	NOUN
admet-1845	194	20	https://doi.org/10.1097/fpc.0b013e32833ffb56	https://doi.org/10.1097/fpc.0b013e32833ffb56	NOUN
admet-1845	194	21	admet	admet	PROPN
admet-1845	194	22	&	&	CCONJ
admet-1845	194	23	dmpk	dmpk	PROPN
admet-1845	194	24	11(4	11(4	NUM
admet-1845	194	25	)	)	PUNCT
admet-1845	194	26	(	(	PUNCT
admet-1845	194	27	2023	2023	NUM
admet-1845	194	28	)	)	PUNCT
admet-1845	194	29	551	551	NUM
admet-1845	194	30	-	-	SYM
admet-1845	194	31	560	560	NUM
admet-1845	194	32	drug	drug	NOUN
admet-1845	194	33	encapsulation	encapsulation	NOUN
admet-1845	194	34	and	and	CCONJ
admet-1845	194	35	suppress	suppress	VERB
admet-1845	194	36	the	the	DET
admet-1845	194	37	adverse	adverse	ADJ
admet-1845	194	38	effect	effect	NOUN
admet-1845	194	39	of	of	ADP
admet-1845	194	40	doxorubicin	doxorubicin	PROPN
admet-1845	194	41	doi	doi	PROPN
admet-1845	194	42	:	:	PUNCT
admet-1845	194	43	https://doi.org/10.5599/adme	https://doi.org/10.5599/adme	NOUN
admet-1845	194	44	t.1845	t.1845	NOUN
admet-1845	194	45	559	559	NUM
admet-1845	194	46	[	[	NOUN
admet-1845	194	47	8	8	NUM
admet-1845	194	48	]	]	X
admet-1845	194	49	r.j	r.j	PROPN
admet-1845	194	50	.	.	PROPN
admet-1845	194	51	rigby	rigby	PROPN
admet-1845	194	52	,	,	PUNCT
admet-1845	194	53	j.	j.	PROPN
admet-1845	194	54	carr	carr	PROPN
admet-1845	194	55	,	,	PUNCT
admet-1845	194	56	k.	k.	PROPN
admet-1845	194	57	orgel	orgel	PROPN
admet-1845	194	58	,	,	PUNCT
admet-1845	194	59	s.l	s.l	PROPN
admet-1845	194	60	.	.	PROPN
admet-1845	194	61	king	king	PROPN
admet-1845	194	62	,	,	PUNCT
admet-1845	194	63	p.k	p.k	PROPN
admet-1845	194	64	.	.	PROPN
admet-1845	194	65	lund	lund	PROPN
admet-1845	194	66	,	,	PUNCT
admet-1845	194	67	c.m	c.m	PROPN
admet-1845	194	68	.	.	PROPN
admet-1845	194	69	dekaney	dekaney	PROPN
admet-1845	194	70	.	.	PUNCT
admet-1845	195	1	intestinal	intestinal	ADJ
admet-1845	195	2	bacteria	bacteria	NOUN
admet-1845	195	3	are	be	AUX
admet-1845	195	4	necessary	necessary	ADJ
admet-1845	195	5	for	for	ADP
admet-1845	195	6	doxorubicin	doxorubicin	NOUN
admet-1845	195	7	-	-	PUNCT
admet-1845	195	8	induced	induce	VERB
admet-1845	195	9	intestinal	intestinal	ADJ
admet-1845	195	10	damage	damage	NOUN
admet-1845	195	11	but	but	CCONJ
admet-1845	195	12	not	not	PART
admet-1845	195	13	for	for	ADP
admet-1845	195	14	doxorubicin	doxorubicin	NOUN
admet-1845	195	15	-	-	PUNCT
admet-1845	195	16	induced	induce	VERB
admet-1845	195	17	apoptosis	apoptosis	NOUN
admet-1845	195	18	.	.	PUNCT
admet-1845	196	1	gut	gut	NOUN
admet-1845	196	2	microbes	microbe	NOUN
admet-1845	196	3	7	7	NUM
admet-1845	196	4	(	(	PUNCT
admet-1845	196	5	2016	2016	NUM
admet-1845	196	6	)	)	PUNCT
admet-1845	196	7	414	414	NUM
admet-1845	196	8	-	-	SYM
admet-1845	196	9	423	423	NUM
admet-1845	196	10	.	.	PUNCT
admet-1845	196	11	https://doi.org/10.1080/19490976.2016.1215806	https://doi.org/10.1080/19490976.2016.1215806	PROPN
admet-1845	197	1	[	[	X
admet-1845	197	2	9	9	NUM
admet-1845	197	3	]	]	PUNCT
admet-1845	197	4	j.-e	j.-e	NOUN
admet-1845	197	5	.	.	PUNCT
admet-1845	198	1	kim	kim	PROPN
admet-1845	198	2	,	,	PUNCT
admet-1845	198	3	h.-j	h.-j	PROPN
admet-1845	198	4	.	.	PUNCT
admet-1845	199	1	cho	cho	PROPN
admet-1845	199	2	,	,	PUNCT
admet-1845	199	3	j.s	j.s	PROPN
admet-1845	199	4	.	.	PUNCT
admet-1845	199	5	kim	kim	PROPN
admet-1845	199	6	,	,	PUNCT
admet-1845	199	7	c.-k	c.-k	PROPN
admet-1845	199	8	.	.	PUNCT
admet-1845	200	1	shim	shim	NOUN
admet-1845	200	2	,	,	PUNCT
admet-1845	200	3	s.-j	s.-j	PROPN
admet-1845	200	4	.	.	PUNCT
admet-1845	201	1	chung	chung	PROPN
admet-1845	201	2	,	,	PUNCT
admet-1845	201	3	m.-h	m.-h	PROPN
admet-1845	201	4	.	.	PUNCT
admet-1845	202	1	oak	oak	NOUN
admet-1845	202	2	,	,	PUNCT
admet-1845	202	3	i.-s	i.-	NOUN
admet-1845	202	4	.	.	PUNCT
admet-1845	203	1	yoon	yoon	PROPN
admet-1845	203	2	,	,	PUNCT
admet-1845	203	3	d.-d	d.-d	PROPN
admet-1845	203	4	.	.	PUNCT
admet-1845	204	1	kim	kim	PROPN
admet-1845	204	2	.	.	PUNCT
admet-1845	205	1	the	the	DET
admet-1845	205	2	limited	limited	ADJ
admet-1845	205	3	intestinal	intestinal	ADJ
admet-1845	205	4	absorption	absorption	NOUN
admet-1845	205	5	via	via	ADP
admet-1845	205	6	paracellular	paracellular	ADJ
admet-1845	205	7	pathway	pathway	NOUN
admet-1845	205	8	is	be	AUX
admet-1845	205	9	responsible	responsible	ADJ
admet-1845	205	10	for	for	ADP
admet-1845	205	11	the	the	DET
admet-1845	205	12	low	low	ADJ
admet-1845	205	13	oral	oral	ADJ
admet-1845	205	14	bioavailability	bioavailability	NOUN
admet-1845	205	15	of	of	ADP
admet-1845	205	16	doxorubicin	doxorubicin	PROPN
admet-1845	205	17	.	.	PUNCT
admet-1845	206	1	xenobiotica	xenobiotica	PROPN
admet-1845	206	2	43	43	NUM
admet-1845	206	3	(	(	PUNCT
admet-1845	206	4	2013	2013	NUM
admet-1845	206	5	)	)	PUNCT
admet-1845	206	6	579	579	NUM
admet-1845	206	7	-	-	SYM
admet-1845	206	8	591	591	NUM
admet-1845	206	9	.	.	PUNCT
admet-1845	207	1	https://doi.org/10.3109/00498254.2012.751140	https://doi.org/10.3109/00498254.2012.751140	PROPN
admet-1845	208	1	[	[	X
admet-1845	208	2	10	10	NUM
admet-1845	208	3	]	]	X
admet-1845	208	4	s.	s.	PROPN
admet-1845	208	5	kotamraju	kotamraju	PROPN
admet-1845	208	6	,	,	PUNCT
admet-1845	208	7	e.a	e.a	PROPN
admet-1845	208	8	.	.	PROPN
admet-1845	208	9	konorev	konorev	PROPN
admet-1845	208	10	,	,	PUNCT
admet-1845	208	11	j.	j.	PROPN
admet-1845	208	12	joseph	joseph	PROPN
admet-1845	208	13	,	,	PUNCT
admet-1845	208	14	b.	b.	PROPN
admet-1845	208	15	kalyanaraman	kalyanaraman	PROPN
admet-1845	208	16	.	.	PUNCT
admet-1845	208	17	doxorubicin	doxorubicin	PROPN
admet-1845	208	18	-	-	PUNCT
admet-1845	208	19	induced	induce	VERB
admet-1845	208	20	apoptosis	apoptosis	NOUN
admet-1845	208	21	in	in	ADP
admet-1845	208	22	endothelial	endothelial	ADJ
admet-1845	208	23	cells	cell	NOUN
admet-1845	208	24	and	and	CCONJ
admet-1845	208	25	cardiomyocytes	cardiomyocyte	NOUN
admet-1845	208	26	is	be	AUX
admet-1845	208	27	ameliorated	ameliorate	VERB
admet-1845	208	28	by	by	ADP
admet-1845	208	29	nitrone	nitrone	NOUN
admet-1845	208	30	spin	spin	NOUN
admet-1845	208	31	traps	trap	NOUN
admet-1845	208	32	and	and	CCONJ
admet-1845	208	33	ebselen	ebselen	NOUN
admet-1845	208	34	:	:	PUNCT
admet-1845	208	35	role	role	NOUN
admet-1845	208	36	of	of	ADP
admet-1845	208	37	reactive	reactive	ADJ
admet-1845	208	38	oxygen	oxygen	NOUN
admet-1845	208	39	and	and	CCONJ
admet-1845	208	40	nitrogen	nitrogen	NOUN
admet-1845	208	41	species	specie	NOUN
admet-1845	208	42	.	.	PUNCT
admet-1845	209	1	journal	journal	NOUN
admet-1845	209	2	of	of	ADP
admet-1845	209	3	biological	biological	ADJ
admet-1845	209	4	chemistry	chemistry	NOUN
admet-1845	209	5	275	275	NUM
admet-1845	209	6	(	(	PUNCT
admet-1845	209	7	2000	2000	NUM
admet-1845	209	8	)	)	PUNCT
admet-1845	209	9	33585	33585	NUM
admet-1845	209	10	-	-	SYM
admet-1845	209	11	33592	33592	NUM
admet-1845	209	12	.	.	PUNCT
admet-1845	210	1	https://doi.org/10.1074/	https://doi.org/10.1074/	NOUN
admet-1845	210	2	jbc.m003890200	jbc.m003890200	PUNCT
admet-1845	211	1	[	[	X
admet-1845	211	2	11	11	NUM
admet-1845	211	3	]	]	PUNCT
admet-1845	211	4	m.	m.	NOUN
admet-1845	211	5	elsabahy	elsabahy	PROPN
admet-1845	211	6	,	,	PUNCT
admet-1845	211	7	k.l	k.l	PROPN
admet-1845	211	8	.	.	PROPN
admet-1845	211	9	wooley	wooley	PROPN
admet-1845	211	10	.	.	PUNCT
admet-1845	212	1	design	design	NOUN
admet-1845	212	2	of	of	ADP
admet-1845	212	3	polymeric	polymeric	ADJ
admet-1845	212	4	nanoparticles	nanoparticle	NOUN
admet-1845	212	5	for	for	ADP
admet-1845	212	6	biomedical	biomedical	ADJ
admet-1845	212	7	delivery	delivery	NOUN
admet-1845	212	8	applications	application	NOUN
admet-1845	212	9	.	.	PUNCT
admet-1845	213	1	chemical	chemical	PROPN
admet-1845	213	2	society	society	PROPN
admet-1845	213	3	reviews	review	VERB
admet-1845	213	4	41	41	NUM
admet-1845	213	5	(	(	PUNCT
admet-1845	213	6	2012	2012	NUM
admet-1845	213	7	)	)	PUNCT
admet-1845	213	8	2545	2545	NUM
admet-1845	213	9	-	-	SYM
admet-1845	213	10	2561	2561	NUM
admet-1845	213	11	.	.	PUNCT
admet-1845	214	1	https://doi.org/10.1039/c2cs15327k	https://doi.org/10.1039/c2cs15327k	PUNCT
admet-1845	215	1	[	[	X
admet-1845	215	2	12	12	NUM
admet-1845	215	3	]	]	X
admet-1845	215	4	n.	n.	PROPN
admet-1845	215	5	kamaly	kamaly	PROPN
admet-1845	215	6	,	,	PUNCT
admet-1845	215	7	b.	b.	PROPN
admet-1845	215	8	yameen	yameen	PROPN
admet-1845	215	9	,	,	PUNCT
admet-1845	215	10	j.	j.	PROPN
admet-1845	215	11	wu	wu	PROPN
admet-1845	215	12	,	,	PUNCT
admet-1845	215	13	o.c	o.c	PROPN
admet-1845	215	14	.	.	PROPN
admet-1845	215	15	farokhzad	farokhzad	PROPN
admet-1845	215	16	.	.	PUNCT
admet-1845	216	1	degradable	degradable	ADJ
admet-1845	216	2	controlled	control	VERB
admet-1845	216	3	-	-	PUNCT
admet-1845	216	4	release	release	NOUN
admet-1845	216	5	polymers	polymer	NOUN
admet-1845	216	6	and	and	CCONJ
admet-1845	216	7	polymeric	polymeric	ADJ
admet-1845	216	8	nanoparticles	nanoparticle	NOUN
admet-1845	216	9	:	:	PUNCT
admet-1845	216	10	mechanisms	mechanism	NOUN
admet-1845	216	11	of	of	ADP
admet-1845	216	12	controlling	control	VERB
admet-1845	216	13	drug	drug	NOUN
admet-1845	216	14	release	release	NOUN
admet-1845	216	15	.	.	PUNCT
admet-1845	217	1	chemical	chemical	ADJ
admet-1845	217	2	reviews	review	NOUN
admet-1845	217	3	116	116	NUM
admet-1845	217	4	(	(	PUNCT
admet-1845	217	5	2016	2016	NUM
admet-1845	217	6	)	)	PUNCT
admet-1845	217	7	2602	2602	NUM
admet-1845	217	8	-	-	SYM
admet-1845	217	9	2663	2663	NUM
admet-1845	217	10	.	.	PUNCT
admet-1845	218	1	https://doi.org/10.1021/acs.chemrev.5b00346	https://doi.org/10.1021/acs.chemrev.5b00346	VERB
admet-1845	218	2	[	[	PUNCT
admet-1845	218	3	13	13	NUM
admet-1845	218	4	]	]	PUNCT
admet-1845	218	5	h.	h.	PROPN
admet-1845	218	6	otsuka	otsuka	PROPN
admet-1845	218	7	,	,	PUNCT
admet-1845	218	8	y.	y.	PROPN
admet-1845	218	9	nagasaki	nagasaki	PROPN
admet-1845	218	10	,	,	PUNCT
admet-1845	218	11	k.	k.	PROPN
admet-1845	218	12	kataoka	kataoka	PROPN
admet-1845	218	13	.	.	PUNCT
admet-1845	219	1	pegylated	pegylate	VERB
admet-1845	219	2	nanoparticles	nanoparticle	NOUN
admet-1845	219	3	for	for	ADP
admet-1845	219	4	biological	biological	ADJ
admet-1845	219	5	and	and	CCONJ
admet-1845	219	6	pharmaceutical	pharmaceutical	NOUN
admet-1845	219	7	applications	application	NOUN
admet-1845	219	8	.	.	PUNCT
admet-1845	220	1	advanced	advanced	ADJ
admet-1845	220	2	drug	drug	NOUN
admet-1845	220	3	delivery	delivery	NOUN
admet-1845	220	4	reviews	review	VERB
admet-1845	220	5	55	55	NUM
admet-1845	220	6	(	(	PUNCT
admet-1845	220	7	2012	2012	NUM
admet-1845	220	8	)	)	PUNCT
admet-1845	220	9	403	403	NUM
admet-1845	220	10	-	-	SYM
admet-1845	220	11	419	419	NUM
admet-1845	220	12	.	.	PUNCT
admet-1845	221	1	https://doi.org/10.1016/j.addr.20	https://doi.org/10.1016/j.addr.20	X
admet-1845	222	1	12.09.022	12.09.022	NOUN
admet-1845	223	1	[	[	X
admet-1845	223	2	14	14	NUM
admet-1845	223	3	]	]	X
admet-1845	223	4	t.x	t.x	PROPN
admet-1845	223	5	.	.	PROPN
admet-1845	223	6	nguyen	nguyen	PROPN
admet-1845	223	7	,	,	PUNCT
admet-1845	223	8	l.	l.	PROPN
admet-1845	223	9	huang	huang	PROPN
admet-1845	223	10	,	,	PUNCT
admet-1845	223	11	m.	m.	NOUN
admet-1845	223	12	gauthier	gauthier	PROPN
admet-1845	223	13	,	,	PUNCT
admet-1845	223	14	g.	g.	PROPN
admet-1845	223	15	yang	yang	PROPN
admet-1845	223	16	,	,	PUNCT
admet-1845	223	17	q.	q.	PROPN
admet-1845	223	18	wang	wang	PROPN
admet-1845	223	19	.	.	PUNCT
admet-1845	224	1	recent	recent	ADJ
admet-1845	224	2	advances	advance	NOUN
admet-1845	224	3	in	in	ADP
admet-1845	224	4	liposome	liposome	NOUN
admet-1845	224	5	surface	surface	NOUN
admet-1845	224	6	modification	modification	NOUN
admet-1845	224	7	for	for	ADP
admet-1845	224	8	oral	oral	ADJ
admet-1845	224	9	drug	drug	NOUN
admet-1845	224	10	delivery	delivery	NOUN
admet-1845	224	11	.	.	PUNCT
admet-1845	225	1	nanomedicine	nanomedicine	NOUN
admet-1845	225	2	11	11	NUM
admet-1845	225	3	(	(	PUNCT
admet-1845	225	4	2016	2016	NUM
admet-1845	225	5	)	)	PUNCT
admet-1845	225	6	1169	1169	NUM
admet-1845	225	7	-	-	SYM
admet-1845	225	8	1185	1185	NUM
admet-1845	225	9	.	.	PUNCT
admet-1845	226	1	https://doi.org/10.2217/	https://doi.org/10.2217/	NOUN
admet-1845	226	2	nnm.16.9	nnm.16.9	NOUN
admet-1845	226	3	[	[	X
admet-1845	226	4	15	15	NUM
admet-1845	226	5	]	]	PUNCT
admet-1845	226	6	j.	j.	PROPN
admet-1845	226	7	wang	wang	PROPN
admet-1845	226	8	,	,	PUNCT
admet-1845	226	9	l.	l.	PROPN
admet-1845	226	10	li	li	PROPN
admet-1845	226	11	,	,	PUNCT
admet-1845	226	12	l.	l.	PROPN
admet-1845	226	13	wu	wu	PROPN
admet-1845	226	14	,	,	PUNCT
admet-1845	226	15	b.	b.	PROPN
admet-1845	226	16	sun	sun	PROPN
admet-1845	226	17	,	,	PUNCT
admet-1845	226	18	y.	y.	PROPN
admet-1845	226	19	du	du	PROPN
admet-1845	226	20	,	,	PUNCT
admet-1845	226	21	j.	j.	PROPN
admet-1845	226	22	sun	sun	PROPN
admet-1845	226	23	,	,	PUNCT
admet-1845	226	24	y.	y.	PROPN
admet-1845	226	25	wang	wang	PROPN
admet-1845	226	26	,	,	PUNCT
admet-1845	226	27	q.	q.	PROPN
admet-1845	226	28	fu	fu	PROPN
admet-1845	226	29	,	,	PUNCT
admet-1845	226	30	p.	p.	PROPN
admet-1845	226	31	zhang	zhang	PROPN
admet-1845	226	32	,	,	PUNCT
admet-1845	227	1	z.	z.	PROPN
admet-1845	227	2	he	he	PRON
admet-1845	227	3	.	.	PUNCT
admet-1845	228	1	development	development	NOUN
admet-1845	228	2	of	of	ADP
admet-1845	228	3	novel	novel	NOUN
admet-1845	228	4	selfassembled	selfassemble	VERB
admet-1845	228	5	es	es	VERB
admet-1845	228	6	-	-	PUNCT
admet-1845	228	7	plga	plga	NOUN
admet-1845	228	8	hybrid	hybrid	ADJ
admet-1845	228	9	nanoparticles	nanoparticle	NOUN
admet-1845	228	10	for	for	ADP
admet-1845	228	11	improving	improve	VERB
admet-1845	228	12	oral	oral	ADJ
admet-1845	228	13	absorption	absorption	NOUN
admet-1845	228	14	of	of	ADP
admet-1845	228	15	doxorubicin	doxorubicin	PROPN
admet-1845	228	16	hydrochloride	hydrochloride	NOUN
admet-1845	228	17	by	by	ADP
admet-1845	228	18	p	p	NOUN
admet-1845	228	19	-	-	PUNCT
admet-1845	228	20	gp	gp	NOUN
admet-1845	228	21	inhibition	inhibition	NOUN
admet-1845	228	22	:	:	PUNCT
admet-1845	228	23	in	in	ADP
admet-1845	228	24	vitro	vitro	X
admet-1845	228	25	and	and	CCONJ
admet-1845	228	26	in	in	ADP
admet-1845	228	27	vivo	vivo	ADJ
admet-1845	228	28	evaluation	evaluation	NOUN
admet-1845	228	29	.	.	PUNCT
admet-1845	229	1	european	european	ADJ
admet-1845	229	2	journal	journal	PROPN
admet-1845	229	3	of	of	ADP
admet-1845	229	4	pharmaceutical	pharmaceutical	PROPN
admet-1845	229	5	sciences	science	NOUN
admet-1845	229	6	99	99	NUM
admet-1845	229	7	(	(	PUNCT
admet-1845	229	8	2017	2017	NUM
admet-1845	229	9	)	)	PUNCT
admet-1845	229	10	185	185	NUM
admet-1845	229	11	-	-	SYM
admet-1845	229	12	192	192	NUM
admet-1845	229	13	.	.	PUNCT
admet-1845	229	14	https://doi.org/10.1016/j.ejps.2016.12.014	https://doi.org/10.1016/j.ejps.2016.12.014	NOUN
admet-1845	229	15	.	.	PUNCT
admet-1845	230	1	[	[	X
admet-1845	230	2	16	16	NUM
admet-1845	230	3	]	]	PUNCT
admet-1845	230	4	j.	j.	PROPN
admet-1845	230	5	wang	wang	PROPN
admet-1845	230	6	,	,	PUNCT
admet-1845	230	7	l.	l.	PROPN
admet-1845	230	8	li	li	PROPN
admet-1845	230	9	,	,	PUNCT
admet-1845	230	10	y.	y.	PROPN
admet-1845	230	11	du	du	PROPN
admet-1845	230	12	,	,	PUNCT
admet-1845	230	13	j.	j.	PROPN
admet-1845	230	14	sun	sun	PROPN
admet-1845	230	15	,	,	PUNCT
admet-1845	230	16	x.	x.	PROPN
admet-1845	230	17	han	han	PROPN
admet-1845	230	18	,	,	PUNCT
admet-1845	230	19	c.	c.	PROPN
admet-1845	230	20	luo	luo	PROPN
admet-1845	230	21	,	,	PUNCT
admet-1845	230	22	x.	x.	NOUN
admet-1845	230	23	ai	ai	PROPN
admet-1845	230	24	,	,	PUNCT
admet-1845	230	25	q.	q.	PROPN
admet-1845	230	26	zhang	zhang	PROPN
admet-1845	230	27	,	,	PUNCT
admet-1845	230	28	y.	y.	PROPN
admet-1845	230	29	wang	wang	PROPN
admet-1845	230	30	,	,	PUNCT
admet-1845	230	31	q.	q.	PROPN
admet-1845	230	32	fu	fu	PROPN
admet-1845	230	33	.	.	PUNCT
admet-1845	230	34	improved	improve	VERB
admet-1845	230	35	oral	oral	ADJ
admet-1845	230	36	absorption	absorption	NOUN
admet-1845	230	37	of	of	ADP
admet-1845	230	38	doxorubicin	doxorubicin	PROPN
admet-1845	230	39	by	by	ADP
admet-1845	230	40	amphiphilic	amphiphilic	ADJ
admet-1845	230	41	copolymer	copolymer	NOUN
admet-1845	230	42	of	of	ADP
admet-1845	230	43	lysine	lysine	NOUN
admet-1845	230	44	-	-	PUNCT
admet-1845	230	45	linked	link	VERB
admet-1845	230	46	ditocopherol	ditocopherol	NOUN
admet-1845	230	47	polyethylene	polyethylene	NOUN
admet-1845	230	48	glycol	glycol	NOUN
admet-1845	230	49	2000	2000	NUM
admet-1845	230	50	succinate	succinate	NOUN
admet-1845	230	51	:	:	PUNCT
admet-1845	230	52	in	in	ADP
admet-1845	230	53	vitro	vitro	X
admet-1845	230	54	characterization	characterization	NOUN
admet-1845	230	55	and	and	CCONJ
admet-1845	230	56	in	in	ADP
admet-1845	230	57	vivo	vivo	ADJ
admet-1845	230	58	evaluation	evaluation	NOUN
admet-1845	230	59	.	.	PUNCT
admet-1845	231	1	molecular	molecular	ADJ
admet-1845	231	2	pharmaceutics	pharmaceutic	NOUN
admet-1845	231	3	12	12	NUM
admet-1845	231	4	(	(	PUNCT
admet-1845	231	5	2015	2015	NUM
admet-1845	231	6	)	)	PUNCT
admet-1845	231	7	463	463	NUM
admet-1845	231	8	-	-	SYM
admet-1845	231	9	473	473	NUM
admet-1845	231	10	.	.	PUNCT
admet-1845	232	1	https://doi.org/10.1021/mp500833	https://doi.org/10.1021/mp500833	NOUN
admet-1845	232	2	m	m	PRON
admet-1845	233	1	[	[	X
admet-1845	233	2	17	17	NUM
admet-1845	233	3	]	]	X
admet-1845	233	4	l.b	l.b	PROPN
admet-1845	233	5	.	.	PROPN
admet-1845	233	6	vong	vong	PROPN
admet-1845	233	7	,	,	PUNCT
admet-1845	233	8	t.	t.	NOUN
admet-1845	233	9	yoshitomi	yoshitomi	NOUN
admet-1845	233	10	,	,	PUNCT
admet-1845	233	11	h.	h.	PROPN
admet-1845	233	12	matsui	matsui	PROPN
admet-1845	233	13	,	,	PUNCT
admet-1845	233	14	y.	y.	PROPN
admet-1845	233	15	nagasaki	nagasaki	PROPN
admet-1845	233	16	.	.	PUNCT
admet-1845	234	1	development	development	NOUN
admet-1845	234	2	of	of	ADP
admet-1845	234	3	an	an	DET
admet-1845	234	4	oral	oral	ADJ
admet-1845	234	5	nanotherapeutics	nanotherapeutic	NOUN
admet-1845	234	6	using	use	VERB
admet-1845	234	7	redox	redox	ADJ
admet-1845	234	8	nanoparticles	nanoparticle	NOUN
admet-1845	234	9	for	for	ADP
admet-1845	234	10	treatment	treatment	NOUN
admet-1845	234	11	of	of	ADP
admet-1845	234	12	colitis	colitis	NOUN
admet-1845	234	13	-	-	PUNCT
admet-1845	234	14	associated	associate	VERB
admet-1845	234	15	colon	colon	NOUN
admet-1845	234	16	cancer	cancer	NOUN
admet-1845	234	17	.	.	PUNCT
admet-1845	235	1	biomaterials	biomaterial	NOUN
admet-1845	235	2	55	55	NUM
admet-1845	235	3	(	(	PUNCT
admet-1845	235	4	2015	2015	NUM
admet-1845	235	5	)	)	PUNCT
admet-1845	235	6	54	54	NUM
admet-1845	235	7	-	-	SYM
admet-1845	235	8	63	63	NUM
admet-1845	235	9	.	.	PUNCT
admet-1845	236	1	https://doi.org/10.1016/j.biomaterials.2015.03.037	https://doi.org/10.1016/j.biomaterials.2015.03.037	NOUN
admet-1845	236	2	[	[	X
admet-1845	236	3	18	18	NUM
admet-1845	236	4	]	]	PUNCT
admet-1845	236	5	t.	t.	NOUN
admet-1845	236	6	yoshitomi	yoshitomi	NOUN
admet-1845	236	7	,	,	PUNCT
admet-1845	236	8	y.	y.	PROPN
admet-1845	236	9	ozaki	ozaki	PROPN
admet-1845	236	10	,	,	PUNCT
admet-1845	236	11	s.	s.	PROPN
admet-1845	236	12	thangavel	thangavel	PROPN
admet-1845	236	13	,	,	PUNCT
admet-1845	236	14	y.	y.	PROPN
admet-1845	236	15	nagasaki	nagasaki	PROPN
admet-1845	236	16	.	.	PUNCT
admet-1845	237	1	redox	redox	ADJ
admet-1845	237	2	nanoparticle	nanoparticle	NOUN
admet-1845	237	3	therapeutics	therapeutic	NOUN
admet-1845	237	4	to	to	ADP
admet-1845	237	5	cancer	cancer	NOUN
admet-1845	237	6	—	—	PUNCT
admet-1845	237	7	increase	increase	NOUN
admet-1845	237	8	in	in	ADP
admet-1845	237	9	therapeutic	therapeutic	ADJ
admet-1845	237	10	effect	effect	NOUN
admet-1845	237	11	of	of	ADP
admet-1845	237	12	doxorubicin	doxorubicin	PROPN
admet-1845	237	13	,	,	PUNCT
admet-1845	237	14	suppressing	suppress	VERB
admet-1845	237	15	its	its	PRON
admet-1845	237	16	adverse	adverse	ADJ
admet-1845	237	17	effect	effect	NOUN
admet-1845	237	18	.	.	PUNCT
admet-1845	238	1	journal	journal	NOUN
admet-1845	238	2	of	of	ADP
admet-1845	238	3	controlled	control	VERB
admet-1845	238	4	release	release	NOUN
admet-1845	238	5	172	172	NUM
admet-1845	238	6	(	(	PUNCT
admet-1845	238	7	2013	2013	NUM
admet-1845	238	8	)	)	PUNCT
admet-1845	238	9	137	137	NUM
admet-1845	238	10	-	-	SYM
admet-1845	238	11	143	143	NUM
admet-1845	238	12	.	.	PUNCT
admet-1845	239	1	https://doi.org/10.1016/j.jconrel.2013.08.011	https://doi.org/10.1016/j.jconrel.2013.08.011	NOUN
admet-1845	239	2	[	[	X
admet-1845	239	3	19	19	NUM
admet-1845	239	4	]	]	PUNCT
admet-1845	239	5	p.	p.	NOUN
admet-1845	239	6	chonpathompikunlert	chonpathompikunlert	NOUN
admet-1845	239	7	,	,	PUNCT
admet-1845	239	8	c.-h	c.-h	PROPN
admet-1845	239	9	.	.	PUNCT
admet-1845	240	1	fan	fan	PROPN
admet-1845	240	2	,	,	PUNCT
admet-1845	240	3	y.	y.	PROPN
admet-1845	240	4	ozaki	ozaki	PROPN
admet-1845	240	5	,	,	PUNCT
admet-1845	240	6	t.	t.	NOUN
admet-1845	240	7	yoshitomi	yoshitomi	NOUN
admet-1845	240	8	,	,	PUNCT
admet-1845	240	9	c.-k	c.-k	PROPN
admet-1845	240	10	.	.	PUNCT
admet-1845	241	1	yeh	yeh	PROPN
admet-1845	241	2	,	,	PUNCT
admet-1845	241	3	y.	y.	PROPN
admet-1845	241	4	nagasaki	nagasaki	PROPN
admet-1845	241	5	.	.	PUNCT
admet-1845	242	1	redox	redox	ADJ
admet-1845	242	2	nanoparticle	nanoparticle	NOUN
admet-1845	242	3	treatment	treatment	NOUN
admet-1845	242	4	protects	protect	VERB
admet-1845	242	5	against	against	ADP
admet-1845	242	6	neurological	neurological	ADJ
admet-1845	242	7	deficit	deficit	NOUN
admet-1845	242	8	in	in	ADP
admet-1845	242	9	focused	focus	VERB
admet-1845	242	10	ultrasound	ultrasound	NOUN
admet-1845	242	11	-	-	PUNCT
admet-1845	242	12	induced	induce	VERB
admet-1845	242	13	intracerebral	intracerebral	ADJ
admet-1845	242	14	hemorrhage	hemorrhage	NOUN
admet-1845	242	15	.	.	PUNCT
admet-1845	243	1	nanomedicine	nanomedicine	NOUN
admet-1845	243	2	7	7	NUM
admet-1845	243	3	(	(	PUNCT
admet-1845	243	4	2012	2012	NUM
admet-1845	243	5	)	)	PUNCT
admet-1845	243	6	1029	1029	NUM
admet-1845	243	7	-	-	SYM
admet-1845	243	8	1043	1043	NUM
admet-1845	243	9	.	.	PUNCT
admet-1845	244	1	https://doi.org/10.2217/nnm.12.2	https://doi.org/10.2217/nnm.12.2	ADJ
admet-1845	244	2	[	[	X
admet-1845	244	3	20	20	NUM
admet-1845	244	4	]	]	PUNCT
admet-1845	244	5	t.	t.	NOUN
admet-1845	244	6	yoshitomi	yoshitomi	NOUN
admet-1845	244	7	,	,	PUNCT
admet-1845	244	8	a.	a.	NOUN
admet-1845	244	9	hirayama	hirayama	PROPN
admet-1845	244	10	,	,	PUNCT
admet-1845	244	11	y.	y.	PROPN
admet-1845	244	12	nagasaki	nagasaki	PROPN
admet-1845	244	13	.	.	PUNCT
admet-1845	245	1	the	the	DET
admet-1845	245	2	ros	ros	PROPN
admet-1845	245	3	scavenging	scavenging	NOUN
admet-1845	245	4	and	and	CCONJ
admet-1845	245	5	renal	renal	ADJ
admet-1845	245	6	protective	protective	ADJ
admet-1845	245	7	effects	effect	NOUN
admet-1845	245	8	of	of	ADP
admet-1845	245	9	ph	ph	ADJ
admet-1845	245	10	-	-	ADJ
admet-1845	245	11	responsive	responsive	ADJ
admet-1845	245	12	nitroxide	nitroxide	ADJ
admet-1845	245	13	radical	radical	ADV
admet-1845	245	14	-	-	PUNCT
admet-1845	245	15	containing	contain	VERB
admet-1845	245	16	nanoparticles	nanoparticle	NOUN
admet-1845	245	17	.	.	PUNCT
admet-1845	246	1	biomaterials	biomaterial	NOUN
admet-1845	246	2	32	32	NUM
admet-1845	246	3	(	(	PUNCT
admet-1845	246	4	2011	2011	NUM
admet-1845	246	5	)	)	PUNCT
admet-1845	246	6	8021	8021	NUM
admet-1845	246	7	-	-	SYM
admet-1845	246	8	8028	8028	NUM
admet-1845	246	9	.	.	PUNCT
admet-1845	247	1	https://doi.org/0.1016/	https://doi.org/0.1016/	DET
admet-1845	247	2	j.biomaterials.2011.07.014	j.biomaterials.2011.07.014	PROPN
admet-1845	248	1	[	[	X
admet-1845	248	2	21	21	NUM
admet-1845	248	3	]	]	SYM
admet-1845	248	4	t.-h.t	t.-h.t	NOUN
admet-1845	248	5	.	.	PUNCT
admet-1845	248	6	nguyen	nguyen	NOUN
admet-1845	248	7	,	,	PUNCT
admet-1845	248	8	n.-t	n.-t	PROPN
admet-1845	248	9	.	.	PUNCT
admet-1845	249	1	trinh	trinh	PROPN
admet-1845	249	2	,	,	PUNCT
admet-1845	249	3	h.n	h.n	PROPN
admet-1845	249	4	.	.	PROPN
admet-1845	249	5	tran	tran	PROPN
admet-1845	249	6	,	,	PUNCT
admet-1845	249	7	h.t	h.t	PROPN
admet-1845	249	8	.	.	PROPN
admet-1845	249	9	tran	tran	PROPN
admet-1845	249	10	,	,	PUNCT
admet-1845	249	11	p.q	p.q	PROPN
admet-1845	249	12	.	.	PROPN
admet-1845	249	13	le	le	PROPN
admet-1845	249	14	,	,	PUNCT
admet-1845	249	15	d.-n	d.-n	PROPN
admet-1845	249	16	.	.	PUNCT
admet-1845	250	1	ngo	ngo	PROPN
admet-1845	250	2	,	,	PUNCT
admet-1845	250	3	h.	h.	PROPN
admet-1845	250	4	tran	tran	PROPN
admet-1845	250	5	-	-	PROPN
admet-1845	250	6	van	van	PROPN
admet-1845	250	7	,	,	PUNCT
admet-1845	250	8	t.	t.	PROPN
admet-1845	250	9	van	van	PROPN
admet-1845	250	10	vo	vo	PROPN
admet-1845	250	11	,	,	PUNCT
admet-1845	250	12	l.b	l.b	PROPN
admet-1845	250	13	.	.	PROPN
admet-1845	250	14	vong	vong	PROPN
admet-1845	250	15	,	,	PUNCT
admet-1845	250	16	y.	y.	PROPN
admet-1845	250	17	nagasaki	nagasaki	PROPN
admet-1845	250	18	.	.	PUNCT
admet-1845	251	1	improving	improve	VERB
admet-1845	251	2	silymarin	silymarin	NOUN
admet-1845	251	3	oral	oral	ADJ
admet-1845	251	4	bioavailability	bioavailability	NOUN
admet-1845	251	5	using	use	VERB
admet-1845	251	6	silica	silica	NOUN
admet-1845	251	7	-	-	PUNCT
admet-1845	251	8	installed	instal	VERB
admet-1845	251	9	redox	redox	NOUN
admet-1845	251	10	nanoparticle	nanoparticle	NOUN
admet-1845	251	11	to	to	PART
admet-1845	251	12	suppress	suppress	VERB
admet-1845	251	13	inflammatory	inflammatory	ADJ
admet-1845	251	14	bowel	bowel	NOUN
admet-1845	251	15	disease	disease	NOUN
admet-1845	251	16	.	.	PUNCT
admet-1845	252	1	journal	journal	PROPN
admet-1845	252	2	of	of	ADP
admet-1845	252	3	controlled	control	VERB
admet-1845	252	4	release	release	NOUN
admet-1845	252	5	331	331	NUM
admet-1845	252	6	(	(	PUNCT
admet-1845	252	7	2021	2021	NUM
admet-1845	252	8	)	)	PUNCT
admet-1845	252	9	515	515	NUM
admet-1845	252	10	-	-	SYM
admet-1845	252	11	524	524	NUM
admet-1845	252	12	.	.	PUNCT
admet-1845	253	1	https://doi.org/	https://doi.org/	VERB
admet-1845	253	2	10.1016	10.1016	NUM
admet-1845	253	3	/	/	SYM
admet-1845	253	4	j.jconrel.2020.10.042	j.jconrel.2020.10.042	X
admet-1845	253	5	[	[	X
admet-1845	253	6	22	22	NUM
admet-1845	253	7	]	]	PUNCT
admet-1845	253	8	t.	t.	NOUN
admet-1845	253	9	yoshitomi	yoshitomi	NOUN
admet-1845	253	10	,	,	PUNCT
admet-1845	253	11	y.	y.	PROPN
admet-1845	253	12	nagasaki	nagasaki	PROPN
admet-1845	253	13	.	.	PUNCT
admet-1845	254	1	development	development	NOUN
admet-1845	254	2	of	of	ADP
admet-1845	254	3	silica	silica	NOUN
admet-1845	254	4	-	-	PUNCT
admet-1845	254	5	containing	contain	VERB
admet-1845	254	6	redox	redox	ADJ
admet-1845	254	7	nanoparticles	nanoparticle	NOUN
admet-1845	254	8	for	for	ADP
admet-1845	254	9	medical	medical	ADJ
admet-1845	254	10	applications	application	NOUN
admet-1845	254	11	.	.	PUNCT
admet-1845	255	1	biomaterials	biomaterial	NOUN
admet-1845	255	2	science	science	NOUN
admet-1845	255	3	3	3	NUM
admet-1845	255	4	(	(	PUNCT
admet-1845	255	5	2015	2015	NUM
admet-1845	255	6	)	)	PUNCT
admet-1845	255	7	810	810	NUM
admet-1845	255	8	-	-	SYM
admet-1845	255	9	815	815	NUM
admet-1845	255	10	.	.	PUNCT
admet-1845	256	1	https://doi.org/10.1039/c5bm00057b	https://doi.org/10.1039/c5bm00057b	PROPN
admet-1845	257	1	[	[	X
admet-1845	257	2	23	23	NUM
admet-1845	257	3	]	]	X
admet-1845	257	4	h.t	h.t	PROPN
admet-1845	257	5	.	.	PROPN
admet-1845	257	6	tran	tran	PROPN
admet-1845	257	7	,	,	PUNCT
admet-1845	257	8	l.b	l.b	PROPN
admet-1845	257	9	.	.	PROPN
admet-1845	257	10	vong	vong	PROPN
admet-1845	257	11	,	,	PUNCT
admet-1845	257	12	y.	y.	PROPN
admet-1845	257	13	nishikawa	nishikawa	PROPN
admet-1845	257	14	,	,	PUNCT
admet-1845	257	15	y.	y.	PROPN
admet-1845	257	16	nagasaki	nagasaki	PROPN
admet-1845	257	17	.	.	PUNCT
admet-1845	258	1	sorafenib	sorafenib	PROPN
admet-1845	258	2	-	-	PUNCT
admet-1845	258	3	loaded	load	VERB
admet-1845	258	4	silica	silica	NOUN
admet-1845	258	5	-	-	PUNCT
admet-1845	258	6	containing	contain	VERB
admet-1845	258	7	redox	redox	ADJ
admet-1845	258	8	nanoparticles	nanoparticle	NOUN
admet-1845	258	9	for	for	ADP
admet-1845	258	10	oral	oral	ADJ
admet-1845	258	11	anti	anti	ADJ
admet-1845	258	12	-	-	ADJ
admet-1845	258	13	liver	liver	ADJ
admet-1845	258	14	fibrosis	fibrosis	NOUN
admet-1845	258	15	therapy	therapy	NOUN
admet-1845	258	16	.	.	PUNCT
admet-1845	259	1	journal	journal	PROPN
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admet-1845	259	3	controlled	control	VERB
admet-1845	259	4	release	release	NOUN
admet-1845	259	5	345	345	NUM
admet-1845	259	6	(	(	PUNCT
admet-1845	259	7	2022	2022	NUM
admet-1845	259	8	)	)	PUNCT
admet-1845	259	9	880	880	NUM
admet-1845	259	10	-	-	SYM
admet-1845	259	11	891	891	NUM
admet-1845	259	12	.	.	PUNCT
admet-1845	260	1	https://doi.org/	https://doi.org/	VERB
admet-1845	260	2	10.1016	10.1016	NUM
admet-1845	260	3	/	/	SYM
admet-1845	260	4	j.jconrel.2022.04.002	j.jconrel.2022.04.002	NOUN
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admet-1845	260	6	https://doi.org/10.1080/19490976.2016.1215806	https://doi.org/10.1080/19490976.2016.1215806	PROPN
admet-1845	261	1	https://doi.org/10.3109/00498254.2012.751140	https://doi.org/10.3109/00498254.2012.751140	PROPN
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admet-1845	261	5	https://doi.org/10.1021/acs.chemrev.5b00346	https://doi.org/10.1021/acs.chemrev.5b00346	ADJ
admet-1845	261	6	https://doi.org/10.1016/j.addr.20‌12.09.022	https://doi.org/10.1016/j.addr.20‌12.09.022	NOUN
admet-1845	261	7	https://doi.org/10.1016/j.addr.20‌12.09.022	https://doi.org/10.1016/j.addr.20‌12.09.022	NOUN
admet-1845	261	8	https://doi.org/10.2217/‌nnm.16.9	https://doi.org/10.2217/‌nnm.16.9	PROPN
admet-1845	261	9	https://doi.org/10.2217/‌nnm.16.9	https://doi.org/10.2217/‌nnm.16.9	ADJ
admet-1845	261	10	https://doi.org/10.1016/j.ejps.2016.12.014	https://doi.org/10.1016/j.ejps.2016.12.014	VERB
admet-1845	261	11	https://doi.org/10.1021/mp500833	https://doi.org/10.1021/mp500833	NOUN
admet-1845	261	12	m	m	VERB
admet-1845	261	13	https://doi.org/10.1016/j.biomaterials.2015.03.037	https://doi.org/10.1016/j.biomaterials.2015.03.037	VERB
admet-1845	261	14	https://doi.org/10.1016/j.jconrel.2013.08.011	https://doi.org/10.1016/j.jconrel.2013.08.011	NOUN
admet-1845	261	15	https://doi.org/10.2217/nnm.12.2	https://doi.org/10.2217/nnm.12.2	ADJ
admet-1845	261	16	https://doi.org/0.1016/‌j.biomaterials.2011.07.014	https://doi.org/0.1016/‌j.biomaterials.2011.07.014	PROPN
admet-1845	261	17	https://doi.org/0.1016/‌j.biomaterials.2011.07.014	https://doi.org/0.1016/‌j.biomaterials.2011.07.014	NOUN
admet-1845	261	18	https://doi.org/‌10.1016/j.jconrel.2020.10.042	https://doi.org/‌10.1016/j.jconrel.2020.10.042	PUNCT
admet-1845	261	19	https://doi.org/‌10.1016/j.jconrel.2020.10.042	https://doi.org/‌10.1016/j.jconrel.2020.10.042	PUNCT
admet-1845	261	20	https://doi.org/10.1039/c5bm00057b	https://doi.org/10.1039/c5bm00057b	PROPN
admet-1845	261	21	https://doi.org/‌10.1016/j.jconrel.2022.04.002	https://doi.org/‌10.1016/j.jconrel.2022.04.002	NOUN
admet-1845	261	22	https://doi.org/‌10.1016/j.jconrel.2022.04.002	https://doi.org/‌10.1016/j.jconrel.2022.04.002	NOUN
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admet-1845	262	1	quoc	quoc	PROPN
admet-1845	262	2	tang	tang	INTJ
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admet-1845	262	4	al	al	PROPN
admet-1845	262	5	.	.	PROPN
admet-1845	262	6	admet	admet	PROPN
admet-1845	262	7	&	&	CCONJ
admet-1845	262	8	dmpk	dmpk	PROPN
admet-1845	262	9	11(4	11(4	NUM
admet-1845	262	10	)	)	PUNCT
admet-1845	262	11	(	(	PUNCT
admet-1845	262	12	2023	2023	NUM
admet-1845	262	13	)	)	PUNCT
admet-1845	262	14	551	551	NUM
admet-1845	262	15	-	-	SYM
admet-1845	262	16	560	560	NUM
admet-1845	262	17	560	560	NUM
admet-1845	262	18	[	[	X
admet-1845	262	19	24	24	NUM
admet-1845	262	20	]	]	PUNCT
admet-1845	262	21	m.	m.	NOUN
admet-1845	262	22	su	su	PROPN
admet-1845	262	23	,	,	PUNCT
admet-1845	262	24	h.	h.	PROPN
admet-1845	262	25	su	su	PROPN
admet-1845	262	26	,	,	PUNCT
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admet-1845	262	33	g.	g.	PROPN
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admet-1845	262	35	,	,	PUNCT
admet-1845	262	36	s.	s.	PROPN
admet-1845	262	37	wang	wang	PROPN
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admet-1845	263	1	mesoporous	mesoporous	ADJ
admet-1845	263	2	silica	silica	NOUN
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admet-1845	263	4	monodispersed	monodisperse	VERB
admet-1845	263	5	pores	pore	NOUN
admet-1845	263	6	synthesized	synthesize	VERB
admet-1845	263	7	from	from	ADP
admet-1845	263	8	the	the	DET
admet-1845	263	9	controlled	control	VERB
admet-1845	263	10	self	self	NOUN
admet-1845	263	11	-	-	PUNCT
admet-1845	263	12	assembly	assembly	NOUN
admet-1845	263	13	of	of	ADP
admet-1845	263	14	silica	silica	NOUN
admet-1845	263	15	nanoparticles	nanoparticle	NOUN
admet-1845	263	16	.	.	PUNCT
admet-1845	264	1	korean	korean	ADJ
admet-1845	264	2	journal	journal	PROPN
admet-1845	264	3	of	of	ADP
admet-1845	264	4	chemical	chemical	PROPN
admet-1845	264	5	engineering	engineering	NOUN
admet-1845	264	6	32	32	NUM
admet-1845	264	7	(	(	PUNCT
admet-1845	264	8	2015	2015	NUM
admet-1845	264	9	)	)	PUNCT
admet-1845	264	10	852	852	NUM
admet-1845	264	11	-	-	SYM
admet-1845	264	12	859	859	NUM
admet-1845	264	13	.	.	PUNCT
admet-1845	265	1	https://doi.org/10.1007/s11814-014-0270-5	https://doi.org/10.1007/s11814-014-0270-5	PROPN
admet-1845	266	1	[	[	X
admet-1845	266	2	25	25	NUM
admet-1845	266	3	]	]	X
admet-1845	266	4	d.j	d.j	PROPN
admet-1845	266	5	.	.	PROPN
admet-1845	266	6	mcclements	mcclements	PROPN
admet-1845	266	7	.	.	PUNCT
admet-1845	267	1	edible	edible	ADJ
admet-1845	267	2	lipid	lipid	NOUN
admet-1845	267	3	nanoparticles	nanoparticle	NOUN
admet-1845	267	4	:	:	PUNCT
admet-1845	267	5	digestion	digestion	NOUN
admet-1845	267	6	,	,	PUNCT
admet-1845	267	7	absorption	absorption	NOUN
admet-1845	267	8	,	,	PUNCT
admet-1845	267	9	and	and	CCONJ
admet-1845	267	10	potential	potential	ADJ
admet-1845	267	11	toxicity	toxicity	NOUN
admet-1845	267	12	.	.	PUNCT
admet-1845	268	1	progress	progress	NOUN
admet-1845	268	2	in	in	ADP
admet-1845	268	3	lipid	lipid	ADJ
admet-1845	268	4	research	research	NOUN
admet-1845	268	5	52	52	NUM
admet-1845	268	6	(	(	PUNCT
admet-1845	268	7	2013	2013	NUM
admet-1845	268	8	)	)	PUNCT
admet-1845	268	9	409	409	NUM
admet-1845	268	10	-	-	SYM
admet-1845	268	11	423	423	NUM
admet-1845	268	12	.	.	PUNCT
admet-1845	269	1	https://doi.org/10.1016/j.plipres.2013.04.008	https://doi.org/10.1016/j.plipres.2013.04.008	NOUN
admet-1845	270	1	[	[	X
admet-1845	270	2	26	26	NUM
admet-1845	270	3	]	]	X
admet-1845	270	4	s.	s.	PROPN
admet-1845	270	5	abbad	abbad	PROPN
admet-1845	270	6	,	,	PUNCT
admet-1845	270	7	c.	c.	PROPN
admet-1845	270	8	wang	wang	PROPN
admet-1845	270	9	,	,	PUNCT
admet-1845	270	10	a.y	a.y	PROPN
admet-1845	270	11	.	.	PROPN
admet-1845	270	12	waddad	waddad	PROPN
admet-1845	270	13	,	,	PUNCT
admet-1845	270	14	h.	h.	PROPN
admet-1845	270	15	lv	lv	PROPN
admet-1845	270	16	,	,	PUNCT
admet-1845	270	17	j.	j.	PROPN
admet-1845	270	18	zhou	zhou	PROPN
admet-1845	270	19	.	.	PUNCT
admet-1845	271	1	preparation	preparation	NOUN
admet-1845	271	2	,	,	PUNCT
admet-1845	271	3	in	in	ADP
admet-1845	271	4	vitro	vitro	X
admet-1845	271	5	and	and	CCONJ
admet-1845	271	6	in	in	ADP
admet-1845	271	7	vivo	vivo	ADJ
admet-1845	271	8	evaluation	evaluation	NOUN
admet-1845	271	9	of	of	ADP
admet-1845	271	10	poly	poly	ADJ
admet-1845	271	11	meric	meric	NOUN
admet-1845	271	12	nanoparticles	nanoparticle	NOUN
admet-1845	271	13	based	base	VERB
admet-1845	271	14	on	on	ADP
admet-1845	271	15	hyaluronic	hyaluronic	ADJ
admet-1845	271	16	acid	acid	NOUN
admet-1845	271	17	-	-	PUNCT
admet-1845	271	18	poly	poly	NOUN
admet-1845	271	19	(	(	PUNCT
admet-1845	271	20	butyl	butyl	NOUN
admet-1845	271	21	cyanoacrylate	cyanoacrylate	NOUN
admet-1845	271	22	)	)	PUNCT
admet-1845	271	23	and	and	CCONJ
admet-1845	271	24	d	d	X
admet-1845	271	25	-	-	ADJ
admet-1845	271	26	alpha	alpha	ADJ
admet-1845	271	27	-	-	PUNCT
admet-1845	271	28	tocopheryl	tocopheryl	NOUN
admet-1845	271	29	polyethylene	polyethylene	NOUN
admet-1845	271	30	glycol	glycol	NOUN
admet-1845	271	31	1000	1000	NUM
admet-1845	271	32	succinate	succinate	NOUN
admet-1845	271	33	for	for	ADP
admet-1845	271	34	tumor	tumor	NOUN
admet-1845	271	35	-	-	PUNCT
admet-1845	271	36	targeted	target	VERB
admet-1845	271	37	delivery	delivery	NOUN
admet-1845	271	38	of	of	ADP
admet-1845	271	39	morin	morin	NOUN
admet-1845	271	40	hydrate	hydrate	NOUN
admet-1845	271	41	.	.	PUNCT
admet-1845	272	1	international	international	ADJ
admet-1845	272	2	journal	journal	NOUN
admet-1845	272	3	of	of	ADP
admet-1845	272	4	nanomedicine	nanomedicine	NOUN
admet-1845	272	5	10	10	NUM
admet-1845	272	6	(	(	PUNCT
admet-1845	272	7	2015	2015	NUM
admet-1845	272	8	)	)	PUNCT
admet-1845	272	9	305	305	NUM
admet-1845	272	10	.	.	PUNCT
admet-1845	273	1	https://doi.org/10.2147/ijn.s73971	https://doi.org/10.2147/ijn.s73971	X
admet-1845	274	1	[	[	X
admet-1845	274	2	27	27	NUM
admet-1845	274	3	]	]	PUNCT
admet-1845	274	4	j.	j.	PROPN
admet-1845	274	5	li	li	PROPN
admet-1845	274	6	,	,	PUNCT
admet-1845	274	7	z.	z.	PROPN
admet-1845	274	8	li	li	PROPN
admet-1845	274	9	,	,	PUNCT
admet-1845	274	10	t.	t.	PROPN
admet-1845	274	11	zhou	zhou	PROPN
admet-1845	274	12	,	,	PUNCT
admet-1845	274	13	j.	j.	PROPN
admet-1845	274	14	zhang	zhang	PROPN
admet-1845	274	15	,	,	PUNCT
admet-1845	274	16	h.	h.	PROPN
admet-1845	274	17	xia	xia	PROPN
admet-1845	274	18	,	,	PUNCT
admet-1845	274	19	h.	h.	PROPN
admet-1845	274	20	li	li	PROPN
admet-1845	274	21	,	,	PUNCT
admet-1845	274	22	j.	j.	PROPN
admet-1845	274	23	he	he	PROPN
admet-1845	274	24	,	,	PUNCT
admet-1845	274	25	s.	s.	PROPN
admet-1845	274	26	he	he	PRON
admet-1845	274	27	,	,	PUNCT
admet-1845	274	28	l.	l.	PROPN
admet-1845	274	29	wang	wang	PROPN
admet-1845	274	30	.	.	PUNCT
admet-1845	275	1	positively	positively	ADV
admet-1845	275	2	charged	charge	VERB
admet-1845	275	3	micelles	micelle	NOUN
admet-1845	275	4	based	base	VERB
admet-1845	275	5	on	on	ADP
admet-1845	275	6	a	a	DET
admet-1845	275	7	triblock	triblock	NOUN
admet-1845	275	8	copolymer	copolymer	NOUN
admet-1845	275	9	demonstrate	demonstrate	NOUN
admet-1845	275	10	enhanced	enhance	VERB
admet-1845	275	11	corneal	corneal	ADJ
admet-1845	275	12	penetration	penetration	NOUN
admet-1845	275	13	.	.	PUNCT
admet-1845	276	1	international	international	ADJ
admet-1845	276	2	journal	journal	NOUN
admet-1845	276	3	of	of	ADP
admet-1845	276	4	nanomedicine	nanomedicine	NOUN
admet-1845	276	5	10	10	NUM
admet-1845	276	6	(	(	PUNCT
admet-1845	276	7	2015	2015	NUM
admet-1845	276	8	)	)	PUNCT
admet-1845	276	9	6027	6027	NUM
admet-1845	276	10	.	.	PUNCT
admet-1845	277	1	https://doi.org/10.2147/ijn.s90347	https://doi.org/10.2147/ijn.s90347	PRON
admet-1845	278	1	[	[	X
admet-1845	278	2	28	28	NUM
admet-1845	278	3	]	]	X
admet-1845	278	4	y.	y.	PROPN
admet-1845	278	5	wang	wang	PROPN
admet-1845	278	6	,	,	PUNCT
admet-1845	278	7	l.	l.	PROPN
admet-1845	278	8	li	li	PROPN
admet-1845	278	9	,	,	PUNCT
admet-1845	278	10	j.	j.	PROPN
admet-1845	278	11	li	li	PROPN
admet-1845	278	12	,	,	PUNCT
admet-1845	278	13	b.	b.	PROPN
admet-1845	278	14	yang	yang	PROPN
admet-1845	278	15	,	,	PUNCT
admet-1845	278	16	c.	c.	PROPN
admet-1845	278	17	wang	wang	PROPN
admet-1845	278	18	,	,	PUNCT
admet-1845	278	19	w.	w.	PROPN
admet-1845	278	20	fang	fang	PROPN
admet-1845	278	21	,	,	PUNCT
admet-1845	278	22	f.	f.	PROPN
admet-1845	278	23	ji	ji	PROPN
admet-1845	278	24	,	,	PUNCT
admet-1845	278	25	y.	y.	PROPN
admet-1845	278	26	wen	wen	PROPN
admet-1845	278	27	,	,	PUNCT
admet-1845	278	28	f.	f.	PROPN
admet-1845	278	29	yao	yao	PROPN
admet-1845	278	30	.	.	PUNCT
admet-1845	279	1	stable	stable	ADJ
admet-1845	279	2	and	and	CCONJ
admet-1845	279	3	ph	ph	ADJ
admet-1845	279	4	-	-	PUNCT
admet-1845	279	5	responsive	responsive	ADJ
admet-1845	279	6	polyamidoamine	polyamidoamine	NOUN
admet-1845	279	7	based	base	VERB
admet-1845	279	8	unimolecular	unimolecular	ADJ
admet-1845	279	9	micelles	micelle	NOUN
admet-1845	279	10	capped	cap	VERB
admet-1845	279	11	with	with	ADP
admet-1845	279	12	a	a	DET
admet-1845	279	13	zwitterionic	zwitterionic	ADJ
admet-1845	279	14	polymer	polymer	NOUN
admet-1845	279	15	shell	shell	NOUN
admet-1845	279	16	for	for	ADP
admet-1845	279	17	anticancer	anticancer	NOUN
admet-1845	279	18	drug	drug	NOUN
admet-1845	279	19	delivery	delivery	NOUN
admet-1845	279	20	.	.	PUNCT
admet-1845	280	1	rsc	rsc	PROPN
admet-1845	280	2	advances	advance	VERB
admet-1845	280	3	6	6	NUM
admet-1845	280	4	(	(	PUNCT
admet-1845	280	5	2016	2016	NUM
admet-1845	280	6	)	)	PUNCT
admet-1845	280	7	17728	17728	NUM
admet-1845	280	8	-	-	SYM
admet-1845	280	9	17739	17739	NUM
admet-1845	280	10	.	.	PUNCT
admet-1845	281	1	https://doi.org/10.1039/c5ra25505h	https://doi.org/10.1039/c5ra25505h	PROPN
admet-1845	281	2	[	[	X
admet-1845	281	3	29	29	NUM
admet-1845	281	4	]	]	PUNCT
admet-1845	281	5	q.	q.	PROPN
admet-1845	281	6	zhang	zhang	PROPN
admet-1845	281	7	,	,	PUNCT
admet-1845	281	8	f.	f.	PROPN
admet-1845	281	9	liu	liu	PROPN
admet-1845	281	10	,	,	PUNCT
admet-1845	281	11	k.t	k.t	PROPN
admet-1845	281	12	.	.	PROPN
admet-1845	281	13	nguyen	nguyen	PROPN
admet-1845	281	14	,	,	PUNCT
admet-1845	281	15	x.	x.	PROPN
admet-1845	281	16	ma	ma	PROPN
admet-1845	281	17	,	,	PUNCT
admet-1845	281	18	x.	x.	PROPN
admet-1845	281	19	wang	wang	PROPN
admet-1845	281	20	,	,	PUNCT
admet-1845	281	21	b.	b.	PROPN
admet-1845	281	22	xing	xing	PROPN
admet-1845	281	23	,	,	PUNCT
admet-1845	281	24	y.	y.	PROPN
admet-1845	281	25	zhao	zhao	PROPN
admet-1845	281	26	.	.	PUNCT
admet-1845	282	1	multifunctional	multifunctional	ADJ
admet-1845	282	2	mesoporous	mesoporous	ADJ
admet-1845	282	3	silica	silica	NOUN
admet-1845	282	4	nanoparticles	nanoparticle	NOUN
admet-1845	282	5	for	for	ADP
admet-1845	282	6	cancer‐targeted	cancer‐targete	VERB
admet-1845	282	7	and	and	CCONJ
admet-1845	282	8	controlled	control	VERB
admet-1845	282	9	drug	drug	NOUN
admet-1845	282	10	delivery	delivery	NOUN
admet-1845	282	11	.	.	PUNCT
admet-1845	283	1	advanced	advanced	ADJ
admet-1845	283	2	functional	functional	ADJ
admet-1845	283	3	materials	material	NOUN
admet-1845	283	4	22	22	NUM
admet-1845	283	5	(	(	PUNCT
admet-1845	283	6	2012	2012	NUM
admet-1845	283	7	)	)	PUNCT
admet-1845	283	8	5144	5144	NUM
admet-1845	283	9	-	-	SYM
admet-1845	283	10	5156	5156	NUM
admet-1845	283	11	.	.	PUNCT
admet-1845	284	1	https://doi.org/10.1002/adfm.201201316	https://doi.org/10.1002/adfm.201201316	PROPN
admet-1845	285	1	[	[	X
admet-1845	285	2	30	30	NUM
admet-1845	285	3	]	]	X
admet-1845	285	4	a.c	a.c	PROPN
admet-1845	285	5	.	.	PROPN
admet-1845	285	6	alves	alves	PROPN
admet-1845	285	7	,	,	PUNCT
admet-1845	285	8	a.	a.	NOUN
admet-1845	285	9	magarkar	magarkar	NOUN
admet-1845	285	10	,	,	PUNCT
admet-1845	285	11	m.	m.	PROPN
admet-1845	285	12	horta	horta	PROPN
admet-1845	285	13	,	,	PUNCT
admet-1845	285	14	j.l	j.l	PROPN
admet-1845	285	15	.	.	PROPN
admet-1845	285	16	lima	lima	PROPN
admet-1845	285	17	,	,	PUNCT
admet-1845	285	18	a.	a.	NOUN
admet-1845	285	19	bunker	bunker	PROPN
admet-1845	285	20	,	,	PUNCT
admet-1845	285	21	c.	c.	PROPN
admet-1845	285	22	nunes	nunes	PROPN
admet-1845	285	23	,	,	PUNCT
admet-1845	285	24	s.	s.	PROPN
admet-1845	285	25	reis	reis	PROPN
admet-1845	285	26	.	.	PUNCT
admet-1845	286	1	influence	influence	NOUN
admet-1845	286	2	of	of	ADP
admet-1845	286	3	doxorubicin	doxorubicin	PROPN
admet-1845	286	4	on	on	ADP
admet-1845	286	5	model	model	NOUN
admet-1845	286	6	cell	cell	NOUN
admet-1845	286	7	membrane	membrane	NOUN
admet-1845	286	8	properties	property	NOUN
admet-1845	286	9	:	:	PUNCT
admet-1845	286	10	insights	insight	NOUN
admet-1845	286	11	from	from	ADP
admet-1845	286	12	in	in	ADP
admet-1845	286	13	vitro	vitro	X
admet-1845	286	14	and	and	CCONJ
admet-1845	286	15	in	in	ADP
admet-1845	286	16	silico	silico	NOUN
admet-1845	286	17	studies	study	NOUN
admet-1845	286	18	.	.	PUNCT
admet-1845	287	1	scientific	scientific	ADJ
admet-1845	287	2	reports	report	NOUN
admet-1845	287	3	7	7	NUM
admet-1845	287	4	(	(	PUNCT
admet-1845	287	5	2017	2017	NUM
admet-1845	287	6	)	)	PUNCT
admet-1845	287	7	6343	6343	NUM
admet-1845	287	8	.	.	PUNCT
admet-1845	288	1	https://doi.org/10.1038/s41598-017-06445-z	https://doi.org/10.1038/s41598-017-06445-z	PRON
admet-1845	289	1	[	[	X
admet-1845	289	2	31	31	NUM
admet-1845	289	3	]	]	X
admet-1845	289	4	y.	y.	PROPN
admet-1845	289	5	kato	kato	PROPN
admet-1845	289	6	,	,	PUNCT
admet-1845	289	7	s.	s.	PROPN
admet-1845	289	8	ozawa	ozawa	PROPN
admet-1845	289	9	,	,	PUNCT
admet-1845	289	10	c.	c.	PROPN
admet-1845	289	11	miyamoto	miyamoto	PROPN
admet-1845	289	12	,	,	PUNCT
admet-1845	289	13	y.	y.	PROPN
admet-1845	289	14	maehata	maehata	PROPN
admet-1845	289	15	,	,	PUNCT
admet-1845	289	16	a.	a.	PROPN
admet-1845	289	17	suzuki	suzuki	PROPN
admet-1845	289	18	,	,	PUNCT
admet-1845	289	19	t.	t.	PROPN
admet-1845	289	20	maeda	maeda	PROPN
admet-1845	289	21	,	,	PUNCT
admet-1845	289	22	y.	y.	PROPN
admet-1845	289	23	baba	baba	PROPN
admet-1845	289	24	.	.	PUNCT
admet-1845	290	1	acidic	acidic	ADJ
admet-1845	290	2	extracellular	extracellular	ADJ
admet-1845	290	3	microenvironment	microenvironment	NOUN
admet-1845	290	4	and	and	CCONJ
admet-1845	290	5	cancer	cancer	NOUN
admet-1845	290	6	.	.	PUNCT
admet-1845	291	1	cancer	cancer	NOUN
admet-1845	291	2	cell	cell	NOUN
admet-1845	291	3	international	international	ADJ
admet-1845	291	4	13	13	NUM
admet-1845	291	5	(	(	PUNCT
admet-1845	291	6	2013	2013	NUM
admet-1845	291	7	)	)	PUNCT
admet-1845	291	8	89	89	NUM
admet-1845	291	9	.	.	PUNCT
admet-1845	292	1	https://doi.org/10.1186/14752867-13-89	https://doi.org/10.1186/14752867-13-89	PROPN
admet-1845	293	1	[	[	X
admet-1845	293	2	32	32	NUM
admet-1845	293	3	]	]	X
admet-1845	293	4	e.s	e.s	PROPN
admet-1845	293	5	.	.	PROPN
admet-1845	293	6	lee	lee	PROPN
admet-1845	293	7	,	,	PUNCT
admet-1845	293	8	k.	k.	PROPN
admet-1845	294	1	na	na	PROPN
admet-1845	294	2	,	,	PUNCT
admet-1845	294	3	y.h	y.h	PROPN
admet-1845	294	4	.	.	PROPN
admet-1845	294	5	bae	bae	PROPN
admet-1845	294	6	.	.	PUNCT
admet-1845	295	1	doxorubicin	doxorubicin	PROPN
admet-1845	295	2	loaded	load	VERB
admet-1845	295	3	ph	ph	ADJ
admet-1845	295	4	-	-	ADJ
admet-1845	295	5	sensitive	sensitive	ADJ
admet-1845	295	6	polymeric	polymeric	ADJ
admet-1845	295	7	micelles	micelle	NOUN
admet-1845	295	8	for	for	ADP
admet-1845	295	9	reversal	reversal	NOUN
admet-1845	295	10	of	of	ADP
admet-1845	295	11	resistant	resistant	ADJ
admet-1845	295	12	mcf-7	mcf-7	NOUN
admet-1845	295	13	tumor	tumor	NOUN
admet-1845	295	14	.	.	PUNCT
admet-1845	296	1	journal	journal	PROPN
admet-1845	296	2	of	of	ADP
admet-1845	296	3	controlled	control	VERB
admet-1845	296	4	release	release	NOUN
admet-1845	296	5	103	103	NUM
admet-1845	296	6	(	(	PUNCT
admet-1845	296	7	2005	2005	NUM
admet-1845	296	8	)	)	PUNCT
admet-1845	296	9	405	405	NUM
admet-1845	296	10	-	-	SYM
admet-1845	296	11	418	418	NUM
admet-1845	296	12	.	.	PUNCT
admet-1845	297	1	https://doi.org/10.1016/j.jconrel.20	https://doi.org/10.1016/j.jconrel.20	NOUN
admet-1845	297	2	04.12.018	04.12.018	NUM
admet-1845	298	1	[	[	X
admet-1845	298	2	33	33	NUM
admet-1845	298	3	]	]	X
admet-1845	298	4	q.n	q.n	PROPN
admet-1845	298	5	.	.	PUNCT
admet-1845	298	6	nguyen	nguyen	PROPN
admet-1845	298	7	-	-	PUNCT
admet-1845	298	8	trinh	trinh	PROPN
admet-1845	298	9	,	,	PUNCT
admet-1845	298	10	k.x.t	k.x.t	PROPN
admet-1845	298	11	.	.	PROPN
admet-1845	298	12	trinh	trinh	PROPN
admet-1845	298	13	,	,	PUNCT
admet-1845	298	14	n.-t	n.-t	PROPN
admet-1845	298	15	.	.	PUNCT
admet-1845	299	1	trinh	trinh	PROPN
admet-1845	299	2	,	,	PUNCT
admet-1845	299	3	n.	n.	PROPN
admet-1845	299	4	li	li	PROPN
admet-1845	299	5	,	,	PUNCT
admet-1845	299	6	y.	y.	PROPN
admet-1845	299	7	nagasaki	nagasaki	PROPN
admet-1845	299	8	,	,	PUNCT
admet-1845	299	9	l.b	l.b	PROPN
admet-1845	299	10	.	.	PROPN
admet-1845	299	11	vong	vong	PROPN
admet-1845	299	12	.	.	PUNCT
admet-1845	300	1	a	a	DET
admet-1845	300	2	silica	silica	NOUN
admet-1845	300	3	-	-	PUNCT
admet-1845	300	4	based	base	VERB
admet-1845	300	5	antioxidant	antioxidant	ADJ
admet-1845	300	6	nanoparticle	nanoparticle	NOUN
admet-1845	300	7	for	for	ADP
admet-1845	300	8	oral	oral	ADJ
admet-1845	300	9	delivery	delivery	NOUN
admet-1845	300	10	of	of	ADP
admet-1845	300	11	camptothecin	camptothecin	NOUN
admet-1845	300	12	which	which	PRON
admet-1845	300	13	reduces	reduce	VERB
admet-1845	300	14	intestinal	intestinal	ADJ
admet-1845	300	15	side	side	NOUN
admet-1845	300	16	effects	effect	NOUN
admet-1845	300	17	while	while	SCONJ
admet-1845	300	18	improving	improve	VERB
admet-1845	300	19	drug	drug	NOUN
admet-1845	300	20	efficacy	efficacy	NOUN
admet-1845	300	21	for	for	ADP
admet-1845	300	22	colon	colon	NOUN
admet-1845	300	23	cancer	cancer	NOUN
admet-1845	300	24	treatment	treatment	NOUN
admet-1845	300	25	.	.	PUNCT
admet-1845	301	1	acta	acta	PROPN
admet-1845	301	2	biomaterialia	biomaterialia	PROPN
admet-1845	301	3	143	143	NUM
admet-1845	301	4	(	(	PUNCT
admet-1845	301	5	2022	2022	NUM
admet-1845	301	6	)	)	PUNCT
admet-1845	301	7	459	459	NUM
admet-1845	301	8	-	-	SYM
admet-1845	301	9	470	470	NUM
admet-1845	301	10	.	.	PUNCT
admet-1845	302	1	https://doi.org/10.10	https://doi.org/10.10	PROPN
admet-1845	302	2	16	16	NUM
admet-1845	302	3	/	/	SYM
admet-1845	302	4	j.actbio.2022.02.036	j.actbio.2022.02.036	X
admet-1845	303	1	[	[	X
admet-1845	303	2	34	34	NUM
admet-1845	303	3	]	]	PUNCT
admet-1845	303	4	m.	m.	NOUN
admet-1845	303	5	li	li	PROPN
admet-1845	303	6	,	,	PUNCT
admet-1845	303	7	f.	f.	PROPN
admet-1845	303	8	cheng	cheng	PROPN
admet-1845	303	9	,	,	PUNCT
admet-1845	303	10	c.	c.	PROPN
admet-1845	303	11	xue	xue	PROPN
admet-1845	303	12	,	,	PUNCT
admet-1845	303	13	h.	h.	PROPN
admet-1845	303	14	wang	wang	PROPN
admet-1845	303	15	,	,	PUNCT
admet-1845	303	16	c.	c.	PROPN
admet-1845	303	17	chen	chen	PROPN
admet-1845	303	18	,	,	PUNCT
admet-1845	303	19	q.	q.	PROPN
admet-1845	303	20	du	du	PROPN
admet-1845	303	21	,	,	PUNCT
admet-1845	303	22	d.	d.	PROPN
admet-1845	303	23	ge	ge	PROPN
admet-1845	303	24	,	,	PUNCT
admet-1845	303	25	b.	b.	PROPN
admet-1845	303	26	sun	sun	PROPN
admet-1845	303	27	.	.	PUNCT
admet-1845	304	1	surface	surface	PROPN
admet-1845	304	2	modification	modification	NOUN
admet-1845	304	3	of	of	ADP
admet-1845	304	4	stöber	stöber	PROPN
admet-1845	304	5	silica	silica	NOUN
admet-1845	304	6	nanoparticles	nanoparticle	NOUN
admet-1845	304	7	with	with	ADP
admet-1845	304	8	controlled	control	VERB
admet-1845	304	9	moiety	moiety	NOUN
admet-1845	304	10	densities	density	NOUN
admet-1845	304	11	determines	determine	VERB
admet-1845	304	12	their	their	PRON
admet-1845	304	13	cytotoxicity	cytotoxicity	NOUN
admet-1845	304	14	profiles	profile	NOUN
admet-1845	304	15	in	in	ADP
admet-1845	304	16	macrophages	macrophage	NOUN
admet-1845	304	17	.	.	PUNCT
admet-1845	305	1	langmuir	langmuir	PROPN
admet-1845	305	2	35	35	NUM
admet-1845	305	3	(	(	PUNCT
admet-1845	305	4	2019	2019	NUM
admet-1845	305	5	)	)	PUNCT
admet-1845	305	6	14688	14688	NUM
admet-1845	305	7	-	-	SYM
admet-1845	305	8	14695	14695	NUM
admet-1845	305	9	.	.	PUNCT
admet-1845	306	1	https://doi.org/10.1021/acs.langmuir.9b02578	https://doi.org/10.1021/acs.langmuir.9b02578	VERB
admet-1845	306	2	©	©	PROPN
admet-1845	306	3	2023	2023	NUM
admet-1845	306	4	by	by	ADP
admet-1845	306	5	the	the	DET
admet-1845	306	6	authors	author	NOUN
admet-1845	306	7	;	;	PUNCT
admet-1845	306	8	licensee	licensee	PROPN
admet-1845	306	9	iapc	iapc	PROPN
admet-1845	306	10	,	,	PUNCT
admet-1845	306	11	zagreb	zagreb	PROPN
admet-1845	306	12	,	,	PUNCT
admet-1845	306	13	croatia	croatia	PROPN
admet-1845	306	14	.	.	PUNCT
admet-1845	307	1	this	this	DET
admet-1845	307	2	article	article	NOUN
admet-1845	307	3	is	be	AUX
admet-1845	307	4	an	an	DET
admet-1845	307	5	open	open	ADJ
admet-1845	307	6	-	-	PUNCT
admet-1845	307	7	access	access	NOUN
admet-1845	307	8	article	article	NOUN
admet-1845	307	9	distributed	distribute	VERB
admet-1845	307	10	under	under	ADP
admet-1845	307	11	the	the	DET
admet-1845	307	12	terms	term	NOUN
admet-1845	307	13	and	and	CCONJ
admet-1845	307	14	conditions	condition	NOUN
admet-1845	307	15	of	of	ADP
admet-1845	307	16	the	the	DET
admet-1845	307	17	creative	creative	ADJ
admet-1845	307	18	commons	common	NOUN
admet-1845	307	19	attribution	attribution	NOUN
admet-1845	307	20	license	license	NOUN
admet-1845	307	21	(	(	PUNCT
admet-1845	307	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1845	307	23	)	)	PUNCT
admet-1845	307	24	https://doi.org/10.1007/s11814-014-0270-5	https://doi.org/10.1007/s11814-014-0270-5	NOUN
admet-1845	307	25	https://doi.org/10.1016/j.plipres.2013.04.008	https://doi.org/10.1016/j.plipres.2013.04.008	NOUN
admet-1845	307	26	https://doi.org/10.2147/ijn.s73971	https://doi.org/10.2147/ijn.s73971	X
admet-1845	307	27	https://doi.org/10.2147/ijn.s90347	https://doi.org/10.2147/ijn.s90347	X
admet-1845	307	28	https://doi.org/10.1039/c5ra25505h	https://doi.org/10.1039/c5ra25505h	PROPN
admet-1845	307	29	https://doi.org/10.1002/adfm.201201316	https://doi.org/10.1002/adfm.201201316	VERB
admet-1845	307	30	https://doi.org/10.1038/s41598-017-06445-z	https://doi.org/10.1038/s41598-017-06445-z	PROPN
admet-1845	307	31	https://doi.org/10.1186/1475-2867-13-89	https://doi.org/10.1186/1475-2867-13-89	PROPN
admet-1845	307	32	https://doi.org/10.1186/1475-2867-13-89	https://doi.org/10.1186/1475-2867-13-89	PROPN
admet-1845	307	33	https://doi.org/10.1016/j.jconrel.20‌04.12.018	https://doi.org/10.1016/j.jconrel.20‌04.12.018	PROPN
admet-1845	307	34	https://doi.org/10.1016/j.jconrel.20‌04.12.018	https://doi.org/10.1016/j.jconrel.20‌04.12.018	PROPN
admet-1845	307	35	https://doi.org/10.10‌16/j.actbio.2022.02.036	https://doi.org/10.10‌16/j.actbio.2022.02.036	PROPN
admet-1845	307	36	https://doi.org/10.10‌16/j.actbio.2022.02.036	https://doi.org/10.10‌16/j.actbio.2022.02.036	PROPN
admet-1845	307	37	https://doi.org/10.1021/acs.langmuir.9b02578	https://doi.org/10.1021/acs.langmuir.9b02578	ADP
admet-1845	307	38	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN