id	sid	tid	token	lemma	pos
admet-191	1	1	manuscript	manuscript	PROPN
admet-191	1	2	doi	doi	PROPN
admet-191	1	3	:	:	PUNCT
admet-191	1	4	10.5599	10.5599	NUM
admet-191	1	5	/	/	SYM
admet-191	1	6	admet.3.3.191	admet.3.3.191	NUM
admet-191	1	7	287	287	NUM
admet-191	1	8	admet	admet	X
admet-191	1	9	&	&	CCONJ
admet-191	1	10	dmpk	dmpk	PROPN
admet-191	1	11	3(3	3(3	NUM
admet-191	1	12	)	)	PUNCT
admet-191	1	13	(	(	PUNCT
admet-191	1	14	2015	2015	NUM
admet-191	1	15	)	)	PUNCT
admet-191	1	16	287	287	NUM
admet-191	1	17	-	-	SYM
admet-191	1	18	295	295	NUM
admet-191	1	19	;	;	PUNCT
admet-191	1	20	doi	doi	NOUN
admet-191	1	21	:	:	PUNCT
admet-191	1	22	10.5599	10.5599	NUM
admet-191	1	23	/	/	SYM
admet-191	1	24	admet.3.3.191	admet.3.3.191	NOUN
admet-191	1	25	open	open	ADJ
admet-191	1	26	access	access	NOUN
admet-191	1	27	:	:	PUNCT
admet-191	1	28	issn	issn	PROPN
admet-191	1	29	:	:	PUNCT
admet-191	1	30	1848	1848	NUM
admet-191	1	31	-	-	SYM
admet-191	1	32	7718	7718	NUM
admet-191	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-191	1	34	original	original	ADJ
admet-191	1	35	scientific	scientific	ADJ
admet-191	1	36	paper	paper	NOUN
admet-191	1	37	prion	prion	NOUN
admet-191	1	38	protein	protein	NOUN
admet-191	1	39	and	and	CCONJ
admet-191	1	40	its	its	PRON
admet-191	1	41	interactions	interaction	NOUN
admet-191	1	42	with	with	ADP
admet-191	1	43	metal	metal	NOUN
admet-191	1	44	ions	ion	NOUN
admet-191	1	45	(	(	PUNCT
admet-191	1	46	cu2	cu2	NOUN
admet-191	1	47	+	+	PROPN
admet-191	1	48	,	,	PUNCT
admet-191	1	49	zn2	zn2	PROPN
admet-191	1	50	+	+	PROPN
admet-191	1	51	,	,	PUNCT
admet-191	1	52	and	and	CCONJ
admet-191	1	53	cd2	cd2	NOUN
admet-191	1	54	+	+	NOUN
admet-191	1	55	)	)	PUNCT
admet-191	1	56	and	and	CCONJ
admet-191	1	57	metallothionein	metallothionein	ADJ
admet-191	1	58	3	3	NUM
admet-191	1	59	branislav	branislav	ADJ
admet-191	1	60	ruttkay	ruttkay	PROPN
admet-191	1	61	-	-	PUNCT
admet-191	1	62	nedecky1,2	nedecky1,2	PROPN
admet-191	1	63	,	,	PUNCT
admet-191	1	64	eliska	eliska	ADJ
admet-191	1	65	sedlackova1	sedlackova1	NOUN
admet-191	1	66	,	,	PUNCT
admet-191	1	67	dagmar	dagmar	PROPN
admet-191	1	68	chudobova1,2	chudobova1,2	PROPN
admet-191	1	69	,	,	PUNCT
admet-191	1	70	kristyna	kristyna	PROPN
admet-191	1	71	cihalova1,2	cihalova1,2	PROPN
admet-191	1	72	,	,	PUNCT
admet-191	1	73	ana	ana	PROPN
admet-191	1	74	maria	maria	PROPN
admet-191	1	75	jimenez	jimenez	PROPN
admet-191	1	76	jimenez1,2	jimenez1,2	PROPN
admet-191	1	77	,	,	PUNCT
admet-191	1	78	sona	sona	PROPN
admet-191	1	79	krizkova1,2	krizkova1,2	PROPN
admet-191	1	80	,	,	PUNCT
admet-191	1	81	lukas	lukas	PROPN
admet-191	1	82	richtera1,2	richtera1,2	PROPN
admet-191	1	83	,	,	PUNCT
admet-191	1	84	vojtech	vojtech	NOUN
admet-191	1	85	adam1,2	adam1,2	PROPN
admet-191	1	86	and	and	CCONJ
admet-191	1	87	rene	rene	ADJ
admet-191	1	88	kizek1,2	kizek1,2	PROPN
admet-191	1	89	*	*	PROPN
admet-191	1	90	1	1	NUM
admet-191	1	91	department	department	NOUN
admet-191	1	92	of	of	ADP
admet-191	1	93	chemistry	chemistry	NOUN
admet-191	1	94	and	and	CCONJ
admet-191	1	95	biochemistry	biochemistry	NOUN
admet-191	1	96	,	,	PUNCT
admet-191	1	97	mendel	mendel	PROPN
admet-191	1	98	university	university	PROPN
admet-191	1	99	in	in	ADP
admet-191	1	100	brno	brno	NOUN
admet-191	1	101	,	,	PUNCT
admet-191	1	102	zemedelska	zemedelska	NOUN
admet-191	1	103	1	1	NUM
admet-191	1	104	,	,	PUNCT
admet-191	1	105	cz-613	cz-613	PROPN
admet-191	1	106	00	00	NUM
admet-191	1	107	brno	brno	NOUN
admet-191	1	108	,	,	PUNCT
admet-191	1	109	czech	czech	PROPN
admet-191	1	110	republic	republic	NOUN
admet-191	1	111	,	,	PUNCT
admet-191	1	112	european	european	PROPN
admet-191	1	113	union	union	PROPN
admet-191	1	114	2	2	NUM
admet-191	1	115	central	central	PROPN
admet-191	1	116	european	european	PROPN
admet-191	1	117	institute	institute	PROPN
admet-191	1	118	of	of	ADP
admet-191	1	119	technology	technology	PROPN
admet-191	1	120	,	,	PUNCT
admet-191	1	121	brno	brno	PROPN
admet-191	1	122	university	university	PROPN
admet-191	1	123	of	of	ADP
admet-191	1	124	technology	technology	NOUN
admet-191	1	125	,	,	PUNCT
admet-191	1	126	technicka	technicka	NOUN
admet-191	1	127	3058/10	3058/10	NUM
admet-191	1	128	,	,	PUNCT
admet-191	1	129	cz-616	cz-616	PROPN
admet-191	1	130	00	00	NUM
admet-191	1	131	brno	brno	NOUN
admet-191	1	132	,	,	PUNCT
admet-191	1	133	czech	czech	PROPN
admet-191	1	134	republic	republic	NOUN
admet-191	1	135	,	,	PUNCT
admet-191	1	136	european	european	PROPN
admet-191	1	137	union	union	PROPN
admet-191	1	138	*	*	PUNCT
admet-191	1	139	corresponding	correspond	VERB
admet-191	1	140	author	author	NOUN
admet-191	1	141	:	:	PUNCT
admet-191	2	1	e	e	NOUN
admet-191	2	2	-	-	NOUN
admet-191	2	3	mail	mail	NOUN
admet-191	2	4	:	:	PUNCT
admet-191	2	5	kizek@sci.miuni.cz	kizek@sci.miuni.cz	NOUN
admet-191	2	6	;	;	PUNCT
admet-191	2	7	tel	tel	PROPN
admet-191	2	8	.	.	PROPN
admet-191	2	9	:	:	PUNCT
admet-191	3	1	+420	+420	NUM
admet-191	3	2	-	-	SYM
admet-191	3	3	5	5	NUM
admet-191	3	4	-	-	PUNCT
admet-191	3	5	4513	4513	NUM
admet-191	3	6	-	-	SYM
admet-191	3	7	3350	3350	NUM
admet-191	3	8	;	;	PUNCT
admet-191	3	9	fax	fax	NOUN
admet-191	3	10	:	:	PUNCT
admet-191	3	11	+420	+420	NUM
admet-191	3	12	-	-	PUNCT
admet-191	3	13	5	5	NUM
admet-191	3	14	-	-	PUNCT
admet-191	3	15	4521	4521	NUM
admet-191	3	16	-	-	SYM
admet-191	3	17	2044	2044	NUM
admet-191	3	18	received	receive	VERB
admet-191	3	19	:	:	PUNCT
admet-191	3	20	june	june	PROPN
admet-191	3	21	10	10	NUM
admet-191	3	22	,	,	PUNCT
admet-191	3	23	2015	2015	NUM
admet-191	3	24	;	;	PUNCT
admet-191	3	25	revised	revise	VERB
admet-191	3	26	:	:	PUNCT
admet-191	3	27	august	august	PROPN
admet-191	3	28	02	02	NUM
admet-191	3	29	,	,	PUNCT
admet-191	3	30	2015	2015	NUM
admet-191	3	31	;	;	PUNCT
admet-191	3	32	published	publish	VERB
admet-191	3	33	:	:	PUNCT
admet-191	3	34	september	september	PROPN
admet-191	3	35	05	05	NUM
admet-191	3	36	,	,	PUNCT
admet-191	3	37	2015	2015	NUM
admet-191	3	38	abstract	abstract	NOUN
admet-191	3	39	the	the	DET
admet-191	3	40	effects	effect	NOUN
admet-191	3	41	of	of	ADP
admet-191	3	42	heavy	heavy	ADJ
admet-191	3	43	metals	metal	NOUN
admet-191	3	44	(	(	PUNCT
admet-191	3	45	zn	zn	NOUN
admet-191	3	46	2	2	NUM
admet-191	3	47	+	+	CCONJ
admet-191	3	48	,	,	PUNCT
admet-191	3	49	cu	cu	PROPN
admet-191	3	50	2	2	NUM
admet-191	3	51	+	+	NUM
admet-191	3	52	,	,	PUNCT
admet-191	3	53	and/or	and/or	CCONJ
admet-191	3	54	cd	cd	PROPN
admet-191	3	55	2	2	NUM
admet-191	3	56	+	+	CCONJ
admet-191	3	57	)	)	PUNCT
admet-191	3	58	on	on	ADP
admet-191	3	59	escherichia	escherichia	NOUN
admet-191	3	60	coli	coli	NOUN
admet-191	3	61	expressing	express	VERB
admet-191	3	62	either	either	CCONJ
admet-191	3	63	prion	prion	NOUN
admet-191	3	64	(	(	PUNCT
admet-191	3	65	hprp	hprp	PROPN
admet-191	3	66	c	c	NOUN
admet-191	3	67	)	)	PUNCT
admet-191	3	68	or	or	CCONJ
admet-191	3	69	metallothionein	metallothionein	ADJ
admet-191	3	70	3	3	NUM
admet-191	3	71	(	(	PUNCT
admet-191	3	72	mt-3	mt-3	NOUN
admet-191	3	73	)	)	PUNCT
admet-191	3	74	brain	brain	NOUN
admet-191	3	75	proteins	protein	NOUN
admet-191	3	76	capable	capable	ADJ
admet-191	3	77	of	of	ADP
admet-191	3	78	binding	bind	VERB
admet-191	3	79	these	these	DET
admet-191	3	80	metals	metal	NOUN
admet-191	3	81	were	be	AUX
admet-191	3	82	investigated	investigate	VERB
admet-191	3	83	.	.	PUNCT
admet-191	4	1	the	the	DET
admet-191	4	2	expression	expression	NOUN
admet-191	4	3	of	of	ADP
admet-191	4	4	hprp	hprp	PROPN
admet-191	4	5	c	c	PROPN
admet-191	4	6	or	or	CCONJ
admet-191	4	7	mt-3	mt-3	NOUN
admet-191	4	8	in	in	ADP
admet-191	4	9	e.coli	e.coli	NOUN
admet-191	4	10	was	be	AUX
admet-191	4	11	confirmed	confirm	VERB
admet-191	4	12	using	use	VERB
admet-191	4	13	western	western	ADJ
admet-191	4	14	-	-	PUNCT
admet-191	4	15	blot	blot	NOUN
admet-191	4	16	and	and	CCONJ
admet-191	4	17	dot	dot	NOUN
admet-191	4	18	-	-	PUNCT
admet-191	4	19	blot	blot	NOUN
admet-191	4	20	methods	method	NOUN
admet-191	4	21	.	.	PUNCT
admet-191	5	1	after	after	ADP
admet-191	5	2	analyzing	analyze	VERB
admet-191	5	3	growth	growth	NOUN
admet-191	5	4	curves	curve	NOUN
admet-191	5	5	,	,	PUNCT
admet-191	5	6	we	we	PRON
admet-191	5	7	found	find	VERB
admet-191	5	8	that	that	SCONJ
admet-191	5	9	bacteria	bacteria	NOUN
admet-191	5	10	expressing	express	VERB
admet-191	5	11	prion	prion	NOUN
admet-191	5	12	protein	protein	NOUN
admet-191	5	13	better	well	ADV
admet-191	5	14	tolerated	tolerate	VERB
admet-191	5	15	the	the	DET
admet-191	5	16	presence	presence	NOUN
admet-191	5	17	of	of	ADP
admet-191	5	18	zn	zn	PROPN
admet-191	5	19	2	2	NUM
admet-191	5	20	+	+	CCONJ
admet-191	5	21	in	in	ADP
admet-191	5	22	comparison	comparison	NOUN
admet-191	5	23	with	with	ADP
admet-191	5	24	wild	wild	ADJ
admet-191	5	25	-	-	PUNCT
admet-191	5	26	type	type	NOUN
admet-191	5	27	bacteria	bacteria	NOUN
admet-191	5	28	and	and	CCONJ
admet-191	5	29	bacteria	bacteria	NOUN
admet-191	5	30	expressing	express	VERB
admet-191	5	31	mt-3	mt-3	NOUN
admet-191	5	32	.	.	PUNCT
admet-191	6	1	the	the	DET
admet-191	6	2	addition	addition	NOUN
admet-191	6	3	of	of	ADP
admet-191	6	4	cd	cd	PROPN
admet-191	6	5	2	2	NUM
admet-191	6	6	+	+	NUM
admet-191	6	7	and	and	CCONJ
admet-191	6	8	cu	cu	PROPN
admet-191	6	9	2	2	NUM
admet-191	6	10	+	+	CCONJ
admet-191	6	11	was	be	AUX
admet-191	6	12	well	well	ADV
admet-191	6	13	tolerated	tolerate	VERB
admet-191	6	14	by	by	ADP
admet-191	6	15	bacteria	bacteria	NOUN
admet-191	6	16	expressing	express	VERB
admet-191	6	17	mt-3	mt-3	NOUN
admet-191	6	18	,	,	PUNCT
admet-191	6	19	whereas	whereas	SCONJ
admet-191	6	20	the	the	DET
admet-191	6	21	bacteria	bacteria	NOUN
admet-191	6	22	expressing	express	VERB
admet-191	6	23	prion	prion	NOUN
admet-191	6	24	protein	protein	NOUN
admet-191	6	25	displayed	display	VERB
admet-191	6	26	slower	slow	ADJ
admet-191	6	27	growth	growth	NOUN
admet-191	6	28	when	when	SCONJ
admet-191	6	29	compared	compare	VERB
admet-191	6	30	to	to	ADP
admet-191	6	31	the	the	DET
admet-191	6	32	wild	wild	NOUN
admet-191	6	33	-	-	PUNCT
admet-191	6	34	type	type	NOUN
admet-191	6	35	.	.	PUNCT
admet-191	7	1	we	we	PRON
admet-191	7	2	subsequently	subsequently	ADV
admet-191	7	3	determined	determine	VERB
admet-191	7	4	total	total	ADJ
admet-191	7	5	content	content	NOUN
admet-191	7	6	of	of	ADP
admet-191	7	7	the	the	DET
admet-191	7	8	mt	mt	PROPN
admet-191	7	9	in	in	ADP
admet-191	7	10	bacteria	bacteria	NOUN
admet-191	7	11	using	use	VERB
admet-191	7	12	differential	differential	NOUN
admet-191	7	13	pulsed	pulse	VERB
admet-191	7	14	voltammetry	voltammetry	NOUN
admet-191	7	15	(	(	PUNCT
admet-191	7	16	dpv	dpv	PROPN
admet-191	7	17	)	)	PUNCT
admet-191	7	18	,	,	PUNCT
admet-191	7	19	and	and	CCONJ
admet-191	7	20	depending	depend	VERB
admet-191	7	21	on	on	ADP
admet-191	7	22	the	the	DET
admet-191	7	23	treatment	treatment	NOUN
admet-191	7	24	of	of	ADP
admet-191	7	25	the	the	DET
admet-191	7	26	individual	individual	ADJ
admet-191	7	27	metals	metal	NOUN
admet-191	7	28	.	.	PUNCT
admet-191	8	1	mt	mt	PROPN
admet-191	8	2	expression	expression	NOUN
admet-191	8	3	in	in	ADP
admet-191	8	4	mt3	mt3	NOUN
admet-191	8	5	transformed	transform	VERB
admet-191	8	6	cells	cell	NOUN
admet-191	8	7	as	as	ADV
admet-191	8	8	well	well	ADV
admet-191	8	9	as	as	ADP
admet-191	8	10	in	in	ADP
admet-191	8	11	control	control	NOUN
admet-191	8	12	e.coli	e.coli	NOUN
admet-191	8	13	cells	cell	NOUN
admet-191	8	14	increased	increase	VERB
admet-191	8	15	at	at	ADP
admet-191	8	16	the	the	DET
admet-191	8	17	lowest	low	ADJ
admet-191	8	18	metal	metal	NOUN
admet-191	8	19	concentration	concentration	NOUN
admet-191	8	20	(	(	PUNCT
admet-191	8	21	25	25	NUM
admet-191	8	22	µm	µm	NOUN
admet-191	8	23	)	)	PUNCT
admet-191	8	24	,	,	PUNCT
admet-191	8	25	followed	follow	VERB
admet-191	8	26	by	by	ADP
admet-191	8	27	a	a	DET
admet-191	8	28	decrease	decrease	NOUN
admet-191	8	29	at	at	ADP
admet-191	8	30	higher	high	ADJ
admet-191	8	31	metal	metal	NOUN
admet-191	8	32	concentrations	concentration	NOUN
admet-191	8	33	(	(	PUNCT
admet-191	8	34	50	50	NUM
admet-191	8	35	,	,	PUNCT
admet-191	8	36	75	75	NUM
admet-191	8	37	,	,	PUNCT
admet-191	8	38	and	and	CCONJ
admet-191	8	39	150	150	NUM
admet-191	8	40	µm	µm	NOUN
admet-191	8	41	)	)	PUNCT
admet-191	8	42	.	.	PUNCT
admet-191	9	1	the	the	DET
admet-191	9	2	highest	high	ADJ
admet-191	9	3	increase	increase	NOUN
admet-191	9	4	by	by	ADP
admet-191	9	5	cd	cd	PROPN
admet-191	9	6	2	2	NUM
admet-191	9	7	+	+	CCONJ
admet-191	9	8	were	be	AUX
admet-191	9	9	observed	observe	VERB
admet-191	9	10	.	.	PUNCT
admet-191	10	1	mt	mt	PROPN
admet-191	10	2	expression	expression	NOUN
admet-191	10	3	pattern	pattern	NOUN
admet-191	10	4	in	in	ADP
admet-191	10	5	hprp	hprp	PROPN
admet-191	10	6	c	c	PROPN
admet-191	10	7	transformed	transform	VERB
admet-191	10	8	cells	cell	NOUN
admet-191	10	9	was	be	AUX
admet-191	10	10	different	different	ADJ
admet-191	10	11	.	.	PUNCT
admet-191	11	1	after	after	ADP
admet-191	11	2	application	application	NOUN
admet-191	11	3	of	of	ADP
admet-191	11	4	cu	cu	PROPN
admet-191	11	5	2	2	NUM
admet-191	11	6	+	+	CCONJ
admet-191	11	7	an	an	DET
admet-191	11	8	increase	increase	NOUN
admet-191	11	9	in	in	ADP
admet-191	11	10	mt	mt	PROPN
admet-191	11	11	expression	expression	NOUN
admet-191	11	12	continued	continue	VERB
admet-191	11	13	also	also	ADV
admet-191	11	14	at	at	ADP
admet-191	11	15	higher	high	ADJ
admet-191	11	16	metal	metal	NOUN
admet-191	11	17	concentrations	concentration	NOUN
admet-191	11	18	;	;	PUNCT
admet-191	11	19	and	and	CCONJ
admet-191	11	20	after	after	ADP
admet-191	11	21	application	application	NOUN
admet-191	11	22	of	of	ADP
admet-191	11	23	cd	cd	PROPN
admet-191	11	24	2	2	NUM
admet-191	11	25	+	+	NUM
admet-191	11	26	and	and	CCONJ
admet-191	11	27	zn	zn	PROPN
admet-191	11	28	2	2	NUM
admet-191	11	29	+	+	NUM
admet-191	11	30	no	no	DET
admet-191	11	31	decrease	decrease	NOUN
admet-191	11	32	in	in	ADP
admet-191	11	33	mt	mt	PROPN
admet-191	11	34	expression	expression	NOUN
admet-191	11	35	at	at	ADP
admet-191	11	36	higher	high	ADJ
admet-191	11	37	metal	metal	NOUN
admet-191	11	38	concentrations	concentration	NOUN
admet-191	11	39	was	be	AUX
admet-191	11	40	observed	observe	VERB
admet-191	11	41	.	.	PUNCT
admet-191	12	1	keywords	keyword	NOUN
admet-191	12	2	prion	prion	NOUN
admet-191	12	3	diseases	disease	NOUN
admet-191	12	4	;	;	PUNCT
admet-191	12	5	prp	prp	PROPN
admet-191	12	6	c	c	PROPN
admet-191	12	7	;	;	PUNCT
admet-191	12	8	prpsc	prpsc	PROPN
admet-191	12	9	;	;	PUNCT
admet-191	12	10	mt	mt	PROPN
admet-191	12	11	;	;	PUNCT
admet-191	12	12	mt-3	mt-3	NUM
admet-191	12	13	;	;	PUNCT
admet-191	12	14	copper	copper	NOUN
admet-191	12	15	;	;	PUNCT
admet-191	12	16	zinc	zinc	NOUN
admet-191	12	17	;	;	PUNCT
admet-191	12	18	cadmium	cadmium	NOUN
admet-191	12	19	.	.	PUNCT
admet-191	13	1	introduction	introduction	NOUN
admet-191	13	2	numerous	numerous	ADJ
admet-191	13	3	studies	study	NOUN
admet-191	13	4	suggest	suggest	VERB
admet-191	13	5	that	that	SCONJ
admet-191	13	6	prion	prion	NOUN
admet-191	13	7	disease	disease	NOUN
admet-191	13	8	is	be	AUX
admet-191	13	9	caused	cause	VERB
admet-191	13	10	by	by	ADP
admet-191	13	11	conformational	conformational	ADJ
admet-191	13	12	conversion	conversion	NOUN
admet-191	13	13	of	of	ADP
admet-191	13	14	prpc	prpc	NOUN
admet-191	13	15	(	(	PUNCT
admet-191	13	16	the	the	DET
admet-191	13	17	normal	normal	ADJ
admet-191	13	18	cellular	cellular	ADJ
admet-191	13	19	prion	prion	NOUN
admet-191	13	20	protein	protein	NOUN
admet-191	13	21	)	)	PUNCT
admet-191	13	22	to	to	PART
admet-191	13	23	prpsc	prpsc	VERB
admet-191	13	24	(	(	PUNCT
admet-191	13	25	its	its	PRON
admet-191	13	26	abnormal	abnormal	ADJ
admet-191	13	27	isoform	isoform	NOUN
admet-191	13	28	)	)	PUNCT
admet-191	13	29	,	,	PUNCT
admet-191	13	30	which	which	PRON
admet-191	13	31	becomes	become	VERB
admet-191	13	32	infectious	infectious	ADJ
admet-191	13	33	[	[	X
admet-191	13	34	1	1	NUM
admet-191	13	35	]	]	PUNCT
admet-191	13	36	.	.	PUNCT
admet-191	14	1	in	in	ADP
admet-191	14	2	1982	1982	NUM
admet-191	14	3	,	,	PUNCT
admet-191	14	4	stanley	stanley	PROPN
admet-191	14	5	b.	b.	PROPN
admet-191	14	6	prusiner	prusiner	PROPN
admet-191	14	7	formulated	formulate	VERB
admet-191	14	8	prion	prion	NOUN
admet-191	14	9	theory	theory	NOUN
admet-191	14	10	,	,	PUNCT
admet-191	14	11	recognizing	recognize	VERB
admet-191	14	12	the	the	DET
admet-191	14	13	substance	substance	NOUN
admet-191	14	14	of	of	ADP
admet-191	14	15	which	which	PRON
admet-191	14	16	was	be	AUX
admet-191	14	17	the	the	DET
admet-191	14	18	definition	definition	NOUN
admet-191	14	19	of	of	ADP
admet-191	14	20	the	the	DET
admet-191	14	21	prion	prion	NOUN
admet-191	14	22	protein	protein	NOUN
admet-191	14	23	infectious	infectious	ADJ
admet-191	14	24	particle	particle	NOUN
admet-191	14	25	that	that	PRON
admet-191	14	26	lacks	lack	VERB
admet-191	14	27	nucleic	nucleic	ADJ
admet-191	14	28	acid	acid	NOUN
admet-191	15	1	[	[	X
admet-191	15	2	2	2	NUM
admet-191	15	3	]	]	PUNCT
admet-191	15	4	.	.	PUNCT
admet-191	16	1	prp	prp	PROPN
admet-191	16	2	is	be	AUX
admet-191	16	3	encoded	encode	VERB
admet-191	16	4	by	by	ADP
admet-191	16	5	a	a	DET
admet-191	16	6	single	single	ADJ
admet-191	16	7	copy	copy	NOUN
admet-191	16	8	of	of	ADP
admet-191	16	9	chromosomal	chromosomal	ADJ
admet-191	16	10	gene	gene	NOUN
admet-191	16	11	[	[	X
admet-191	16	12	3	3	NUM
admet-191	16	13	]	]	PUNCT
admet-191	16	14	.	.	PUNCT
admet-191	17	1	the	the	DET
admet-191	17	2	gene	gene	NOUN
admet-191	17	3	encoding	encode	VERB
admet-191	17	4	prp	prp	PROPN
admet-191	17	5	(	(	PUNCT
admet-191	17	6	prnp	prnp	PROPN
admet-191	17	7	)	)	PUNCT
admet-191	17	8	is	be	AUX
admet-191	17	9	a	a	DET
admet-191	17	10	copy	copy	NOUN
admet-191	17	11	of	of	ADP
admet-191	17	12	the	the	DET
admet-191	17	13	gene	gene	NOUN
admet-191	17	14	that	that	PRON
admet-191	17	15	is	be	AUX
admet-191	17	16	located	locate	VERB
admet-191	17	17	on	on	ADP
admet-191	17	18	the	the	DET
admet-191	17	19	20th	20th	ADJ
admet-191	17	20	chromosome	chromosome	NOUN
admet-191	17	21	in	in	ADP
admet-191	17	22	humans	human	NOUN
admet-191	17	23	[	[	X
admet-191	17	24	4	4	NUM
admet-191	17	25	]	]	PUNCT
admet-191	17	26	.	.	PUNCT
admet-191	18	1	prion	prion	NOUN
admet-191	18	2	protein	protein	NOUN
admet-191	18	3	(	(	PUNCT
admet-191	18	4	prpc	prpc	NOUN
admet-191	18	5	)	)	PUNCT
admet-191	18	6	is	be	AUX
admet-191	18	7	a	a	DET
admet-191	18	8	protein	protein	NOUN
admet-191	18	9	naturally	naturally	ADV
admet-191	18	10	present	present	ADJ
admet-191	18	11	in	in	ADP
admet-191	18	12	all	all	DET
admet-191	18	13	mammalian	mammalian	ADJ
admet-191	18	14	cells	cell	NOUN
admet-191	18	15	.	.	PUNCT
admet-191	19	1	cellular	cellular	ADJ
admet-191	19	2	prion	prion	NOUN
admet-191	19	3	protein	protein	NOUN
admet-191	19	4	(	(	PUNCT
admet-191	19	5	prpc	prpc	NOUN
admet-191	19	6	,	,	PUNCT
admet-191	19	7	fig	fig	NOUN
admet-191	19	8	.	.	PUNCT
admet-191	20	1	1a	1a	NOUN
admet-191	20	2	)	)	PUNCT
admet-191	20	3	is	be	AUX
admet-191	20	4	a	a	DET
admet-191	20	5	glycoprotein	glycoprotein	NOUN
admet-191	20	6	that	that	PRON
admet-191	20	7	is	be	AUX
admet-191	20	8	located	locate	VERB
admet-191	20	9	primarily	primarily	ADV
admet-191	20	10	in	in	ADP
admet-191	20	11	the	the	DET
admet-191	20	12	central	central	ADJ
admet-191	20	13	nervous	nervous	ADJ
admet-191	20	14	system	system	NOUN
admet-191	20	15	(	(	PUNCT
admet-191	20	16	cns	cns	NOUN
admet-191	20	17	)	)	PUNCT
admet-191	20	18	,	,	PUNCT
admet-191	20	19	but	but	CCONJ
admet-191	20	20	also	also	ADV
admet-191	20	21	occurs	occur	VERB
admet-191	20	22	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-191	20	23	ruttkay	ruttkay	PROPN
admet-191	20	24	-	-	PUNCT
admet-191	20	25	nedecky	nedecky	PROPN
admet-191	20	26	et	et	PROPN
admet-191	20	27	al	al	PROPN
admet-191	20	28	.	.	PROPN
admet-191	20	29	admet	admet	PROPN
admet-191	20	30	&	&	CCONJ
admet-191	20	31	dmpk	dmpk	PROPN
admet-191	20	32	3(3	3(3	NUM
admet-191	20	33	)	)	PUNCT
admet-191	20	34	(	(	PUNCT
admet-191	20	35	2015	2015	NUM
admet-191	20	36	)	)	PUNCT
admet-191	20	37	287	287	NUM
admet-191	20	38	-	-	SYM
admet-191	20	39	295	295	NUM
admet-191	20	40	288	288	NUM
admet-191	20	41	in	in	ADP
admet-191	20	42	smaller	small	ADJ
admet-191	20	43	quantities	quantity	NOUN
admet-191	20	44	in	in	ADP
admet-191	20	45	other	other	ADJ
admet-191	20	46	tissues	tissue	NOUN
admet-191	20	47	.	.	PUNCT
admet-191	21	1	the	the	DET
admet-191	21	2	physiological	physiological	ADJ
admet-191	21	3	function	function	NOUN
admet-191	21	4	of	of	ADP
admet-191	21	5	this	this	DET
admet-191	21	6	protein	protein	NOUN
admet-191	21	7	is	be	AUX
admet-191	21	8	not	not	PART
admet-191	21	9	yet	yet	ADV
admet-191	21	10	fully	fully	ADV
admet-191	21	11	understood	understand	VERB
admet-191	21	12	,	,	PUNCT
admet-191	21	13	but	but	CCONJ
admet-191	21	14	it	it	PRON
admet-191	21	15	is	be	AUX
admet-191	21	16	probably	probably	ADV
admet-191	21	17	involved	involve	VERB
admet-191	21	18	in	in	ADP
admet-191	21	19	cell	cell	NOUN
admet-191	21	20	differentiation	differentiation	NOUN
admet-191	21	21	and	and	CCONJ
admet-191	21	22	synaptic	synaptic	ADJ
admet-191	21	23	transmission	transmission	NOUN
admet-191	22	1	[	[	X
admet-191	22	2	5	5	NUM
admet-191	22	3	]	]	PUNCT
admet-191	22	4	.	.	PUNCT
admet-191	23	1	posttranslational	posttranslational	ADJ
admet-191	23	2	modifications	modification	NOUN
admet-191	23	3	of	of	ADP
admet-191	23	4	prpc	prpc	NOUN
admet-191	23	5	and	and	CCONJ
admet-191	23	6	conformational	conformational	ADJ
admet-191	23	7	changes	change	NOUN
admet-191	23	8	to	to	ADP
admet-191	23	9	pathological	pathological	ADJ
admet-191	23	10	isoform	isoform	NOUN
admet-191	23	11	prpsc	prpsc	NOUN
admet-191	23	12	are	be	AUX
admet-191	23	13	the	the	DET
admet-191	23	14	molecular	molecular	ADJ
admet-191	23	15	basis	basis	NOUN
admet-191	23	16	of	of	ADP
admet-191	23	17	prion	prion	NOUN
admet-191	23	18	diseases	disease	NOUN
admet-191	23	19	[	[	X
admet-191	23	20	6	6	NUM
admet-191	23	21	]	]	PUNCT
admet-191	23	22	.	.	PUNCT
admet-191	24	1	in	in	ADP
admet-191	24	2	comparison	comparison	NOUN
admet-191	24	3	with	with	ADP
admet-191	24	4	the	the	DET
admet-191	24	5	knowledge	knowledge	NOUN
admet-191	24	6	about	about	ADP
admet-191	24	7	prp	prp	PROPN
admet-191	24	8	c	c	PROPN
admet-191	24	9	,	,	PUNCT
admet-191	24	10	very	very	ADV
admet-191	24	11	little	little	ADJ
admet-191	24	12	is	be	AUX
admet-191	24	13	known	know	VERB
admet-191	24	14	about	about	ADP
admet-191	24	15	prp	prp	PROPN
admet-191	24	16	sc	sc	PROPN
admet-191	24	17	.	.	PUNCT
admet-191	25	1	the	the	DET
admet-191	25	2	pathological	pathological	ADJ
admet-191	25	3	isoform	isoform	NOUN
admet-191	25	4	(	(	PUNCT
admet-191	25	5	prp	prp	PROPN
admet-191	25	6	sc	sc	PROPN
admet-191	25	7	,	,	PUNCT
admet-191	25	8	fig	fig	NOUN
admet-191	25	9	.	.	PUNCT
admet-191	25	10	1b	1b	NUM
admet-191	25	11	)	)	PUNCT
admet-191	25	12	is	be	AUX
admet-191	25	13	highly	highly	ADV
admet-191	25	14	resistant	resistant	ADJ
admet-191	25	15	to	to	ADP
admet-191	25	16	degradation	degradation	NOUN
admet-191	25	17	processes	process	NOUN
admet-191	25	18	in	in	ADP
admet-191	25	19	the	the	DET
admet-191	25	20	cells	cell	NOUN
admet-191	25	21	and	and	CCONJ
admet-191	25	22	,	,	PUNCT
admet-191	25	23	upon	upon	SCONJ
admet-191	25	24	binding	bind	VERB
admet-191	25	25	to	to	ADP
admet-191	25	26	prp	prp	PROPN
admet-191	25	27	c	c	PROPN
admet-191	25	28	proteins	protein	NOUN
admet-191	25	29	these	these	DET
admet-191	25	30	isoforms	isoform	NOUN
admet-191	25	31	will	will	AUX
admet-191	25	32	change	change	VERB
admet-191	25	33	the	the	DET
admet-191	25	34	original	original	ADJ
admet-191	25	35	conformation	conformation	NOUN
admet-191	25	36	to	to	ADP
admet-191	25	37	the	the	DET
admet-191	25	38	conformation	conformation	NOUN
admet-191	25	39	of	of	ADP
admet-191	25	40	prp	prp	PROPN
admet-191	25	41	sc	sc	PROPN
admet-191	25	42	.	.	PUNCT
admet-191	26	1	the	the	DET
admet-191	26	2	presence	presence	NOUN
admet-191	26	3	of	of	ADP
admet-191	26	4	hardly	hardly	ADV
admet-191	26	5	degradable	degradable	ADJ
admet-191	26	6	protein	protein	NOUN
admet-191	26	7	and	and	CCONJ
admet-191	26	8	lack	lack	NOUN
admet-191	26	9	of	of	ADP
admet-191	26	10	physiological	physiological	ADJ
admet-191	26	11	prp	prp	NOUN
admet-191	26	12	c	c	PROPN
admet-191	26	13	therefore	therefore	ADV
admet-191	26	14	will	will	AUX
admet-191	26	15	lead	lead	VERB
admet-191	26	16	to	to	ADP
admet-191	26	17	the	the	DET
admet-191	26	18	emergence	emergence	NOUN
admet-191	26	19	and	and	CCONJ
admet-191	26	20	development	development	NOUN
admet-191	26	21	of	of	ADP
admet-191	26	22	progressive	progressive	ADJ
admet-191	26	23	neurodegenerative	neurodegenerative	ADJ
admet-191	26	24	diseases	disease	NOUN
admet-191	26	25	known	know	VERB
admet-191	26	26	as	as	ADP
admet-191	26	27	transmissible	transmissible	ADJ
admet-191	26	28	spongiform	spongiform	NOUN
admet-191	26	29	encephalopathy	encephalopathy	ADJ
admet-191	26	30	(	(	PUNCT
admet-191	26	31	tse	tse	PROPN
admet-191	26	32	)	)	PUNCT
admet-191	26	33	,	,	PUNCT
admet-191	26	34	which	which	PRON
admet-191	26	35	are	be	AUX
admet-191	26	36	clinically	clinically	ADV
admet-191	26	37	heterogeneous	heterogeneous	ADJ
admet-191	26	38	and	and	CCONJ
admet-191	26	39	currently	currently	ADV
admet-191	26	40	incurable	incurable	ADJ
admet-191	26	41	[	[	X
admet-191	26	42	7	7	NUM
admet-191	26	43	-	-	SYM
admet-191	26	44	9	9	NUM
admet-191	26	45	]	]	PUNCT
admet-191	26	46	.	.	PUNCT
admet-191	27	1	these	these	DET
admet-191	27	2	illnesses	illness	NOUN
admet-191	27	3	in	in	ADP
admet-191	27	4	humans	human	NOUN
admet-191	27	5	and	and	CCONJ
admet-191	27	6	animals	animal	NOUN
admet-191	27	7	include	include	VERB
admet-191	27	8	the	the	DET
admet-191	27	9	following	follow	VERB
admet-191	27	10	diseases	disease	NOUN
admet-191	27	11	:	:	PUNCT
admet-191	27	12	creutzfeldt	creutzfeldt	ADJ
admet-191	27	13	-	-	PUNCT
admet-191	27	14	jakob	jakob	ADJ
admet-191	27	15	disease	disease	NOUN
admet-191	27	16	(	(	PUNCT
admet-191	27	17	cjd	cjd	NOUN
admet-191	27	18	)	)	PUNCT
admet-191	27	19	or	or	CCONJ
admet-191	27	20	gertsman	gertsman	ADJ
admet-191	27	21	-	-	PUNCT
admet-191	27	22	straussler	straussler	NOUN
admet-191	27	23	-	-	PUNCT
admet-191	27	24	schenker	schenker	NOUN
admet-191	27	25	syndrome	syndrome	NOUN
admet-191	27	26	in	in	ADP
admet-191	27	27	humans	human	NOUN
admet-191	27	28	,	,	PUNCT
admet-191	27	29	scrapie	scrapie	NOUN
admet-191	27	30	in	in	ADP
admet-191	27	31	both	both	DET
admet-191	27	32	sheep	sheep	NOUN
admet-191	27	33	and	and	CCONJ
admet-191	27	34	goats	goat	NOUN
admet-191	27	35	,	,	PUNCT
admet-191	27	36	and	and	CCONJ
admet-191	27	37	bovine	bovine	NOUN
admet-191	27	38	spongiform	spongiform	NOUN
admet-191	27	39	encephalopathy	encephalopathy	ADJ
admet-191	27	40	(	(	PUNCT
admet-191	27	41	bse	bse	NOUN
admet-191	27	42	)	)	PUNCT
admet-191	27	43	in	in	ADP
admet-191	27	44	cows	cow	NOUN
admet-191	27	45	.	.	PUNCT
admet-191	28	1	[	[	X
admet-191	28	2	10	10	NUM
admet-191	28	3	-	-	SYM
admet-191	28	4	12	12	NUM
admet-191	28	5	]	]	PUNCT
admet-191	28	6	.	.	PUNCT
admet-191	29	1	experiments	experiment	NOUN
admet-191	29	2	with	with	ADP
admet-191	29	3	tissue	tissue	NOUN
admet-191	29	4	culture	culture	NOUN
admet-191	29	5	of	of	ADP
admet-191	29	6	cerebellum	cerebellum	PROPN
admet-191	29	7	showed	show	VERB
admet-191	29	8	that	that	SCONJ
admet-191	29	9	cells	cell	NOUN
admet-191	29	10	lacking	lack	VERB
admet-191	29	11	prp	prp	PROPN
admet-191	29	12	c	c	PROPN
admet-191	29	13	are	be	AUX
admet-191	29	14	more	more	ADV
admet-191	29	15	susceptible	susceptible	ADJ
admet-191	29	16	to	to	ADP
admet-191	29	17	oxidative	oxidative	ADJ
admet-191	29	18	stress	stress	NOUN
admet-191	29	19	and	and	CCONJ
admet-191	29	20	readily	readily	ADV
admet-191	29	21	undergo	undergo	VERB
admet-191	29	22	cell	cell	NOUN
admet-191	29	23	death	death	NOUN
admet-191	30	1	[	[	X
admet-191	30	2	13	13	NUM
admet-191	30	3	]	]	PUNCT
admet-191	30	4	.	.	PUNCT
admet-191	31	1	some	some	PRON
admet-191	31	2	of	of	ADP
admet-191	31	3	advances	advance	NOUN
admet-191	31	4	in	in	ADP
admet-191	31	5	prion	prion	NOUN
admet-191	31	6	protein	protein	NOUN
admet-191	31	7	detection	detection	NOUN
admet-191	31	8	can	can	AUX
admet-191	31	9	be	be	AUX
admet-191	31	10	found	find	VERB
admet-191	31	11	in	in	ADP
admet-191	31	12	[	[	PUNCT
admet-191	31	13	14	14	NUM
admet-191	31	14	-	-	SYM
admet-191	31	15	19	19	NUM
admet-191	31	16	]	]	PUNCT
admet-191	31	17	.	.	PUNCT
admet-191	32	1	figure	figure	NOUN
admet-191	32	2	1	1	NUM
admet-191	32	3	.	.	PUNCT
admet-191	33	1	(	(	PUNCT
admet-191	33	2	a	a	X
admet-191	33	3	)	)	PUNCT
admet-191	33	4	scheme	scheme	NOUN
admet-191	33	5	of	of	ADP
admet-191	33	6	the	the	DET
admet-191	33	7	structure	structure	NOUN
admet-191	33	8	of	of	ADP
admet-191	33	9	cellular	cellular	ADJ
admet-191	33	10	form	form	NOUN
admet-191	33	11	of	of	ADP
admet-191	33	12	prion	prion	NOUN
admet-191	33	13	protein	protein	NOUN
admet-191	33	14	(	(	PUNCT
admet-191	33	15	prpc	prpc	NOUN
admet-191	33	16	)	)	PUNCT
admet-191	33	17	.	.	PUNCT
admet-191	34	1	(	(	PUNCT
admet-191	34	2	b	b	X
admet-191	34	3	)	)	PUNCT
admet-191	34	4	the	the	DET
admet-191	34	5	structure	structure	NOUN
admet-191	34	6	of	of	ADP
admet-191	34	7	pathological	pathological	ADJ
admet-191	34	8	(	(	PUNCT
admet-191	34	9	abnormal	abnormal	ADJ
admet-191	34	10	)	)	PUNCT
admet-191	34	11	prion	prion	NOUN
admet-191	34	12	protein	protein	NOUN
admet-191	34	13	(	(	PUNCT
admet-191	34	14	prpsc	prpsc	NOUN
admet-191	34	15	)	)	PUNCT
admet-191	34	16	.	.	PUNCT
admet-191	35	1	adapted	adapt	VERB
admet-191	35	2	from	from	ADP
admet-191	35	3	[	[	X
admet-191	35	4	2	2	NUM
admet-191	35	5	]	]	PUNCT
admet-191	35	6	.	.	PUNCT
admet-191	36	1	because	because	SCONJ
admet-191	36	2	the	the	DET
admet-191	36	3	prpc	prpc	NOUN
admet-191	36	4	is	be	AUX
admet-191	36	5	a	a	DET
admet-191	36	6	metal	metal	NOUN
admet-191	36	7	binding	bind	VERB
admet-191	36	8	protein	protein	NOUN
admet-191	36	9	,	,	PUNCT
admet-191	36	10	there	there	PRON
admet-191	36	11	is	be	VERB
admet-191	36	12	a	a	DET
admet-191	36	13	hypothesis	hypothesis	NOUN
admet-191	36	14	that	that	PRON
admet-191	36	15	the	the	DET
admet-191	36	16	metal	metal	NOUN
admet-191	36	17	ions	ion	NOUN
admet-191	36	18	(	(	PUNCT
admet-191	36	19	cu2	cu2	NOUN
admet-191	36	20	+	+	PROPN
admet-191	36	21	,	,	PUNCT
admet-191	36	22	zn2	zn2	PROPN
admet-191	36	23	+	+	PUNCT
admet-191	36	24	and	and	CCONJ
admet-191	36	25	mn2	mn2	VERB
admet-191	36	26	+	+	PRON
admet-191	36	27	)	)	PUNCT
admet-191	36	28	can	can	AUX
admet-191	36	29	play	play	VERB
admet-191	36	30	a	a	DET
admet-191	36	31	role	role	NOUN
admet-191	36	32	in	in	ADP
admet-191	36	33	the	the	DET
admet-191	36	34	transformation	transformation	NOUN
admet-191	36	35	of	of	ADP
admet-191	36	36	prpc	prpc	NOUN
admet-191	36	37	to	to	PART
admet-191	36	38	prpsc	prpsc	VERB
admet-191	36	39	.	.	PUNCT
admet-191	37	1	equally	equally	ADV
admet-191	37	2	important	important	ADJ
admet-191	37	3	link	link	NOUN
admet-191	37	4	between	between	ADP
admet-191	37	5	prion	prion	NOUN
admet-191	37	6	diseases	disease	NOUN
admet-191	37	7	and	and	CCONJ
admet-191	37	8	metals	metal	NOUN
admet-191	37	9	is	be	AUX
admet-191	37	10	a	a	DET
admet-191	37	11	protein	protein	NOUN
admet-191	37	12	called	call	VERB
admet-191	37	13	metallothionein	metallothionein	ADJ
admet-191	37	14	.	.	PUNCT
admet-191	38	1	the	the	DET
admet-191	38	2	brain	brain	NOUN
admet-191	38	3	specific	specific	ADJ
admet-191	38	4	form	form	NOUN
admet-191	38	5	of	of	ADP
admet-191	38	6	metallothionein-3	metallothionein-3	PROPN
admet-191	38	7	(	(	PUNCT
admet-191	38	8	mt-3	mt-3	NUM
admet-191	38	9	)	)	PUNCT
admet-191	38	10	ensures	ensure	VERB
admet-191	38	11	the	the	DET
admet-191	38	12	maintenance	maintenance	NOUN
admet-191	38	13	of	of	ADP
admet-191	38	14	optimal	optimal	ADJ
admet-191	38	15	concentrations	concentration	NOUN
admet-191	38	16	of	of	ADP
admet-191	38	17	metals	metal	NOUN
admet-191	38	18	in	in	ADP
admet-191	38	19	the	the	DET
admet-191	38	20	brain	brain	NOUN
admet-191	38	21	.	.	PUNCT
admet-191	39	1	also	also	ADV
admet-191	39	2	the	the	DET
admet-191	39	3	involvement	involvement	NOUN
admet-191	39	4	of	of	ADP
admet-191	39	5	mt-3	mt-3	NOUN
admet-191	39	6	in	in	ADP
admet-191	39	7	the	the	DET
admet-191	39	8	formation	formation	NOUN
admet-191	39	9	of	of	ADP
admet-191	39	10	neurodegenerative	neurodegenerative	ADJ
admet-191	39	11	diseases	disease	NOUN
admet-191	39	12	was	be	AUX
admet-191	39	13	observed	observe	VERB
admet-191	39	14	as	as	SCONJ
admet-191	39	15	the	the	DET
admet-191	39	16	decrease	decrease	NOUN
admet-191	39	17	in	in	ADP
admet-191	39	18	the	the	DET
admet-191	39	19	mt-3	mt-3	NOUN
admet-191	39	20	levels	level	NOUN
admet-191	39	21	led	lead	VERB
admet-191	39	22	to	to	ADP
admet-191	39	23	the	the	DET
admet-191	39	24	formation	formation	NOUN
admet-191	39	25	of	of	ADP
admet-191	39	26	neurofibrillary	neurofibrillary	ADJ
admet-191	39	27	clusters	cluster	NOUN
admet-191	39	28	characteristic	characteristic	ADJ
admet-191	39	29	for	for	ADP
admet-191	39	30	neurodegenerative	neurodegenerative	ADJ
admet-191	39	31	diseases	disease	NOUN
admet-191	39	32	[	[	X
admet-191	39	33	20	20	NUM
admet-191	39	34	-	-	SYM
admet-191	39	35	22].the	22].the	NUM
admet-191	39	36	aim	aim	NOUN
admet-191	39	37	of	of	ADP
admet-191	39	38	this	this	DET
admet-191	39	39	study	study	NOUN
admet-191	39	40	was	be	AUX
admet-191	39	41	to	to	PART
admet-191	39	42	monitor	monitor	VERB
admet-191	39	43	heavy	heavy	ADJ
admet-191	39	44	metal	metal	NOUN
admet-191	39	45	ions	ion	NOUN
admet-191	39	46	influence	influence	NOUN
admet-191	39	47	on	on	ADP
admet-191	39	48	the	the	DET
admet-191	39	49	growth	growth	NOUN
admet-191	39	50	and	and	CCONJ
admet-191	39	51	electrochemical	electrochemical	ADJ
admet-191	39	52	properties	property	NOUN
admet-191	39	53	of	of	ADP
admet-191	39	54	e.	e.	PROPN
admet-191	39	55	coli	coli	PROPN
admet-191	39	56	strains	strain	NOUN
admet-191	39	57	transformed	transform	VERB
admet-191	39	58	with	with	ADP
admet-191	39	59	prpc	prpc	NOUN
admet-191	39	60	or	or	CCONJ
admet-191	39	61	mt-3	mt-3	NOUN
admet-191	39	62	protein	protein	NOUN
admet-191	39	63	.	.	PUNCT
admet-191	40	1	experimental	experimental	ADJ
admet-191	40	2	chemicals	chemical	NOUN
admet-191	40	3	,	,	PUNCT
admet-191	40	4	preparation	preparation	NOUN
admet-191	40	5	of	of	ADP
admet-191	40	6	deionized	deionize	VERB
admet-191	40	7	water	water	NOUN
admet-191	40	8	and	and	CCONJ
admet-191	40	9	ph	ph	ADJ
admet-191	40	10	measurement	measurement	NOUN
admet-191	40	11	chemicals	chemical	NOUN
admet-191	40	12	used	use	VERB
admet-191	40	13	in	in	ADP
admet-191	40	14	this	this	DET
admet-191	40	15	study	study	NOUN
admet-191	40	16	were	be	AUX
admet-191	40	17	purchased	purchase	VERB
admet-191	40	18	from	from	ADP
admet-191	40	19	sigma	sigma	PROPN
admet-191	40	20	-	-	PUNCT
admet-191	40	21	aldrich	aldrich	PROPN
admet-191	40	22	(	(	PUNCT
admet-191	40	23	st	st	PROPN
admet-191	40	24	.	.	PROPN
admet-191	40	25	louis	louis	PROPN
admet-191	40	26	,	,	PUNCT
admet-191	40	27	mo	mo	PROPN
admet-191	40	28	,	,	PUNCT
admet-191	40	29	usa	usa	PROPN
admet-191	40	30	)	)	PUNCT
admet-191	40	31	in	in	ADP
admet-191	40	32	american	american	PROPN
admet-191	40	33	chemical	chemical	PROPN
admet-191	40	34	society	society	PROPN
admet-191	40	35	(	(	PUNCT
admet-191	40	36	acs	acs	NOUN
admet-191	40	37	)	)	PUNCT
admet-191	40	38	purity	purity	NOUN
admet-191	40	39	unless	unless	SCONJ
admet-191	40	40	noted	note	VERB
admet-191	40	41	otherwise	otherwise	ADV
admet-191	40	42	.	.	PUNCT
admet-191	41	1	the	the	DET
admet-191	41	2	deionized	deionize	VERB
admet-191	41	3	water	water	NOUN
admet-191	41	4	was	be	AUX
admet-191	41	5	prepared	prepare	VERB
admet-191	41	6	using	use	VERB
admet-191	41	7	reverse	reverse	VERB
admet-191	41	8	a	a	DET
admet-191	41	9	b	b	NOUN
admet-191	41	10	admet	admet	X
admet-191	41	11	&	&	CCONJ
admet-191	41	12	dmpk	dmpk	PROPN
admet-191	41	13	3(3	3(3	NUM
admet-191	41	14	)	)	PUNCT
admet-191	41	15	(	(	PUNCT
admet-191	41	16	2015	2015	NUM
admet-191	41	17	)	)	PUNCT
admet-191	41	18	287	287	NUM
admet-191	41	19	-	-	SYM
admet-191	41	20	295	295	NUM
admet-191	41	21	prion	prion	NOUN
admet-191	41	22	interactions	interaction	NOUN
admet-191	41	23	with	with	ADP
admet-191	41	24	metals	metal	NOUN
admet-191	41	25	and	and	CCONJ
admet-191	41	26	metallothionein	metallothionein	ADJ
admet-191	41	27	doi	doi	PROPN
admet-191	41	28	:	:	PUNCT
admet-191	41	29	10.5599	10.5599	NUM
admet-191	41	30	/	/	SYM
admet-191	41	31	admet.3.3.191	admet.3.3.191	NUM
admet-191	41	32	289	289	NUM
admet-191	41	33	osmosis	osmosis	NOUN
admet-191	41	34	equipment	equipment	NOUN
admet-191	41	35	aqual	aqual	NOUN
admet-191	41	36	25	25	NUM
admet-191	41	37	(	(	PUNCT
admet-191	41	38	aqual	aqual	NOUN
admet-191	41	39	s.r.o	s.r.o	NOUN
admet-191	41	40	.	.	PROPN
admet-191	41	41	,	,	PUNCT
admet-191	41	42	brno	brno	PROPN
admet-191	41	43	,	,	PUNCT
admet-191	41	44	czech	czech	PROPN
admet-191	41	45	republic	republic	NOUN
admet-191	41	46	)	)	PUNCT
admet-191	41	47	.	.	PUNCT
admet-191	42	1	the	the	DET
admet-191	42	2	deionized	deionize	VERB
admet-191	42	3	water	water	NOUN
admet-191	42	4	was	be	AUX
admet-191	42	5	further	far	ADV
admet-191	42	6	purified	purify	VERB
admet-191	42	7	at	at	ADP
admet-191	42	8	18	18	NUM
admet-191	42	9	mω	mω	NOUN
admet-191	42	10	resistance	resistance	NOUN
admet-191	42	11	using	use	VERB
admet-191	42	12	miliq	miliq	ADJ
admet-191	42	13	direct	direct	PROPN
admet-191	42	14	quv	quv	PROPN
admet-191	42	15	equipped	equip	VERB
admet-191	42	16	with	with	ADP
admet-191	42	17	uv	uv	NOUN
admet-191	42	18	lamp	lamp	NOUN
admet-191	42	19	.	.	PUNCT
admet-191	43	1	the	the	DET
admet-191	43	2	ph	ph	PROPN
admet-191	43	3	was	be	AUX
admet-191	43	4	measured	measure	VERB
admet-191	43	5	using	use	VERB
admet-191	43	6	ph	ph	ADJ
admet-191	43	7	meter	meter	NOUN
admet-191	43	8	wtw	wtw	PROPN
admet-191	43	9	inolab	inolab	PROPN
admet-191	43	10	(	(	PUNCT
admet-191	43	11	weilheim	weilheim	PROPN
admet-191	43	12	,	,	PUNCT
admet-191	43	13	germany	germany	PROPN
admet-191	43	14	)	)	PUNCT
admet-191	43	15	.	.	PUNCT
admet-191	44	1	chemical	chemical	NOUN
admet-191	44	2	transformation	transformation	NOUN
admet-191	44	3	,	,	PUNCT
admet-191	44	4	growth	growth	NOUN
admet-191	44	5	conditions	condition	NOUN
admet-191	44	6	and	and	CCONJ
admet-191	44	7	isolation	isolation	NOUN
admet-191	44	8	of	of	ADP
admet-191	44	9	protein	protein	NOUN
admet-191	44	10	fraction	fraction	NOUN
admet-191	44	11	the	the	DET
admet-191	44	12	human	human	ADJ
admet-191	44	13	mt-3	mt-3	NOUN
admet-191	44	14	protein	protein	NOUN
admet-191	44	15	(	(	PUNCT
admet-191	44	16	hmt-3	hmt-3	NUM
admet-191	44	17	)	)	PUNCT
admet-191	44	18	and	and	CCONJ
admet-191	44	19	human	human	ADJ
admet-191	44	20	prion	prion	NOUN
admet-191	44	21	protein	protein	NOUN
admet-191	44	22	(	(	PUNCT
admet-191	44	23	hprp	hprp	PROPN
admet-191	44	24	c	c	PROPN
admet-191	44	25	)	)	PUNCT
admet-191	44	26	were	be	AUX
admet-191	44	27	cloned	clone	VERB
admet-191	44	28	in	in	ADP
admet-191	44	29	the	the	DET
admet-191	44	30	prset	prset	ADJ
admet-191	44	31	-	-	PUNCT
admet-191	44	32	b	b	NOUN
admet-191	44	33	vector	vector	NOUN
admet-191	44	34	(	(	PUNCT
admet-191	44	35	invitrogen	invitrogen	PROPN
admet-191	44	36	,	,	PUNCT
admet-191	44	37	usa	usa	PROPN
admet-191	44	38	)	)	PUNCT
admet-191	44	39	.	.	PUNCT
admet-191	45	1	high	high	ADJ
admet-191	45	2	levels	level	NOUN
admet-191	45	3	of	of	ADP
admet-191	45	4	expression	expression	NOUN
admet-191	45	5	of	of	ADP
admet-191	45	6	dna	dna	PROPN
admet-191	45	7	sequences	sequence	NOUN
admet-191	45	8	cloned	clone	VERB
admet-191	45	9	into	into	ADP
admet-191	45	10	the	the	DET
admet-191	45	11	prset	prset	ADJ
admet-191	45	12	vectors	vector	NOUN
admet-191	45	13	were	be	AUX
admet-191	45	14	made	make	VERB
admet-191	45	15	possible	possible	ADJ
admet-191	45	16	by	by	ADP
admet-191	45	17	the	the	DET
admet-191	45	18	presence	presence	NOUN
admet-191	45	19	of	of	ADP
admet-191	45	20	the	the	DET
admet-191	45	21	t7	t7	PROPN
admet-191	45	22	promoter	promoter	NOUN
admet-191	45	23	.	.	PUNCT
admet-191	46	1	the	the	DET
admet-191	46	2	chemical	chemical	PROPN
admet-191	46	3	transformation	transformation	NOUN
admet-191	46	4	protocol	protocol	NOUN
admet-191	46	5	was	be	AUX
admet-191	46	6	performed	perform	VERB
admet-191	46	7	following	follow	VERB
admet-191	46	8	the	the	DET
admet-191	46	9	instructions	instruction	NOUN
admet-191	46	10	of	of	ADP
admet-191	46	11	new	new	PROPN
admet-191	46	12	england	england	PROPN
admet-191	46	13	biolabs	biolabs	PROPN
admet-191	46	14	,	,	PUNCT
admet-191	46	15	using	use	VERB
admet-191	46	16	as	as	ADP
admet-191	46	17	host	host	NOUN
admet-191	46	18	bl21	bl21	PROPN
admet-191	46	19	(	(	PUNCT
admet-191	46	20	de3	de3	NOUN
admet-191	46	21	)	)	PUNCT
admet-191	46	22	plyss	plyss	NOUN
admet-191	46	23	chemically	chemically	ADV
admet-191	46	24	competent	competent	ADJ
admet-191	46	25	e.	e.	PROPN
admet-191	46	26	coli	coli	PROPN
admet-191	46	27	strain	strain	NOUN
admet-191	46	28	.	.	PUNCT
admet-191	47	1	bacteria	bacteria	NOUN
admet-191	47	2	transformed	transform	VERB
admet-191	47	3	with	with	ADP
admet-191	47	4	prset	prset	NOUN
admet-191	47	5	-	-	PUNCT
admet-191	47	6	hmt-3	hmt-3	NOUN
admet-191	47	7	or	or	CCONJ
admet-191	47	8	prset	prset	NOUN
admet-191	47	9	-	-	PUNCT
admet-191	47	10	hprp	hprp	NOUN
admet-191	47	11	c	c	NOUN
admet-191	47	12	plasmid	plasmid	NOUN
admet-191	47	13	were	be	AUX
admet-191	47	14	selected	select	VERB
admet-191	47	15	by	by	ADP
admet-191	47	16	ampicillin	ampicillin	PROPN
admet-191	47	17	resistance	resistance	NOUN
admet-191	47	18	.	.	PUNCT
admet-191	48	1	the	the	DET
admet-191	48	2	positive	positive	ADJ
admet-191	48	3	transformants	transformant	NOUN
admet-191	48	4	were	be	AUX
admet-191	48	5	confirmed	confirm	VERB
admet-191	48	6	by	by	ADP
admet-191	48	7	pcr	pcr	ADJ
admet-191	48	8	screening	screening	NOUN
admet-191	48	9	.	.	PUNCT
admet-191	49	1	the	the	DET
admet-191	49	2	positive	positive	ADJ
admet-191	49	3	transformants	transformant	NOUN
admet-191	49	4	were	be	AUX
admet-191	49	5	grown	grow	VERB
admet-191	49	6	in	in	ADP
admet-191	49	7	lb	lb	X
admet-191	49	8	(	(	PUNCT
admet-191	49	9	luria	luria	PROPN
admet-191	49	10	bertani	bertani	PROPN
admet-191	49	11	)	)	PUNCT
admet-191	49	12	medium	medium	NOUN
admet-191	49	13	(	(	PUNCT
admet-191	49	14	10	10	NUM
admet-191	49	15	g	g	NOUN
admet-191	49	16	tryptone	tryptone	NOUN
admet-191	49	17	,	,	PUNCT
admet-191	49	18	5	5	NUM
admet-191	49	19	g	g	NOUN
admet-191	49	20	yeast	yeast	NOUN
admet-191	49	21	extract	extract	NOUN
admet-191	49	22	,	,	PUNCT
admet-191	49	23	5	5	NUM
admet-191	49	24	g	g	NOUN
admet-191	49	25	nacl	nacl	NOUN
admet-191	49	26	)	)	PUNCT
admet-191	49	27	with	with	ADP
admet-191	49	28	50	50	NUM
admet-191	49	29	µg	µg	NOUN
admet-191	49	30	ml-1	ml-1	PRON
admet-191	49	31	ampicillin	ampicillin	PROPN
admet-191	49	32	and	and	CCONJ
admet-191	49	33	35	35	NUM
admet-191	49	34	µg	µg	ADV
admet-191	49	35	ml-1	ml-1	ADV
admet-191	49	36	chloramphenicol	chloramphenicol	NOUN
admet-191	49	37	shaking	shake	VERB
admet-191	49	38	at	at	ADP
admet-191	49	39	37	37	NUM
admet-191	49	40	°	°	NOUN
admet-191	49	41	c	c	NOUN
admet-191	49	42	overnight	overnight	ADV
admet-191	49	43	.	.	PUNCT
admet-191	50	1	the	the	DET
admet-191	50	2	next	next	ADJ
admet-191	50	3	day	day	NOUN
admet-191	50	4	,	,	PUNCT
admet-191	50	5	each	each	DET
admet-191	50	6	culture	culture	NOUN
admet-191	50	7	was	be	AUX
admet-191	50	8	grown	grow	VERB
admet-191	50	9	to	to	ADP
admet-191	50	10	0.1	0.1	NUM
admet-191	50	11	of	of	ADP
admet-191	50	12	od600	od600	NOUN
admet-191	50	13	nm	nm	PART
admet-191	50	14	.	.	PUNCT
admet-191	51	1	when	when	SCONJ
admet-191	51	2	the	the	DET
admet-191	51	3	culture	culture	NOUN
admet-191	51	4	reached	reach	VERB
admet-191	51	5	the	the	DET
admet-191	51	6	exponential	exponential	ADJ
admet-191	51	7	phase	phase	NOUN
admet-191	51	8	(	(	PUNCT
admet-191	51	9	0.4	0.4	NUM
admet-191	51	10	0.6	0.6	NUM
admet-191	51	11	)	)	PUNCT
admet-191	51	12	,	,	PUNCT
admet-191	51	13	iptg	iptg	X
admet-191	51	14	(	(	PUNCT
admet-191	51	15	isopropylthio	isopropylthio	PROPN
admet-191	51	16	-	-	PUNCT
admet-191	51	17	b	b	NOUN
admet-191	51	18	-	-	PUNCT
admet-191	51	19	d	d	NOUN
admet-191	51	20	-	-	PUNCT
admet-191	51	21	galactopyranoside	galactopyranoside	NOUN
admet-191	51	22	)	)	PUNCT
admet-191	51	23	was	be	AUX
admet-191	51	24	added	add	VERB
admet-191	51	25	to	to	ADP
admet-191	51	26	a	a	DET
admet-191	51	27	final	final	ADJ
admet-191	51	28	concentration	concentration	NOUN
admet-191	51	29	of	of	ADP
admet-191	51	30	1	1	NUM
admet-191	51	31	mm	mm	NOUN
admet-191	51	32	and	and	CCONJ
admet-191	51	33	the	the	DET
admet-191	51	34	cells	cell	NOUN
admet-191	51	35	were	be	AUX
admet-191	51	36	allowed	allow	VERB
admet-191	51	37	to	to	PART
admet-191	51	38	grow	grow	VERB
admet-191	51	39	for	for	ADP
admet-191	51	40	4	4	NUM
admet-191	51	41	to	to	PART
admet-191	51	42	6	6	NUM
admet-191	51	43	hours	hour	NOUN
admet-191	51	44	.	.	PUNCT
admet-191	52	1	after	after	ADP
admet-191	52	2	centrifugation	centrifugation	NOUN
admet-191	52	3	at	at	ADP
admet-191	52	4	4000	4000	NUM
admet-191	52	5	rpm	rpm	NOUN
admet-191	52	6	for	for	ADP
admet-191	52	7	10	10	NUM
admet-191	52	8	min	min	NOUN
admet-191	52	9	,	,	PUNCT
admet-191	52	10	the	the	DET
admet-191	52	11	pellet	pellet	NOUN
admet-191	52	12	was	be	AUX
admet-191	52	13	resuspended	resuspend	VERB
admet-191	52	14	,	,	PUNCT
admet-191	52	15	with	with	ADP
admet-191	52	16	20	20	NUM
admet-191	52	17	mm	mm	NOUN
admet-191	52	18	phosphate	phosphate	NOUN
admet-191	52	19	buffer	buffer	NOUN
admet-191	52	20	at	at	ADP
admet-191	52	21	neutral	neutral	ADJ
admet-191	52	22	ph	ph	NOUN
admet-191	52	23	and	and	CCONJ
admet-191	52	24	frozen	freeze	VERB
admet-191	52	25	in	in	ADP
admet-191	52	26	liquid	liquid	ADJ
admet-191	52	27	nitrogen	nitrogen	NOUN
admet-191	52	28	.	.	PUNCT
admet-191	53	1	the	the	DET
admet-191	53	2	frozen	frozen	ADJ
admet-191	53	3	lysate	lysate	NOUN
admet-191	53	4	was	be	AUX
admet-191	53	5	thawed	thaw	VERB
admet-191	53	6	at	at	ADP
admet-191	53	7	42	42	NUM
admet-191	53	8	°	°	NOUN
admet-191	53	9	c	c	NOUN
admet-191	53	10	(	(	PUNCT
admet-191	53	11	this	this	DET
admet-191	53	12	freeze	freeze	ADJ
admet-191	53	13	-	-	PUNCT
admet-191	53	14	thaw	thaw	NOUN
admet-191	53	15	action	action	NOUN
admet-191	53	16	was	be	AUX
admet-191	53	17	repeated	repeat	VERB
admet-191	53	18	three	three	NUM
admet-191	53	19	times	time	NOUN
admet-191	53	20	)	)	PUNCT
admet-191	53	21	.	.	PUNCT
admet-191	54	1	the	the	DET
admet-191	54	2	protein	protein	NOUN
admet-191	54	3	fraction	fraction	NOUN
admet-191	54	4	was	be	AUX
admet-191	54	5	harvested	harvest	VERB
admet-191	54	6	by	by	ADP
admet-191	54	7	centrifugation	centrifugation	NOUN
admet-191	54	8	at	at	ADP
admet-191	54	9	4000	4000	NUM
admet-191	54	10	rpm	rpm	NOUN
admet-191	54	11	for	for	ADP
admet-191	54	12	10	10	NUM
admet-191	54	13	minutes	minute	NOUN
admet-191	54	14	at	at	ADP
admet-191	54	15	4	4	NUM
admet-191	54	16	°	°	NOUN
admet-191	54	17	c	c	NOUN
admet-191	54	18	.	.	PUNCT
admet-191	55	1	measurement	measurement	NOUN
admet-191	55	2	of	of	ADP
admet-191	55	3	growth	growth	NOUN
admet-191	55	4	curves	curve	NOUN
admet-191	55	5	after	after	ADP
admet-191	55	6	addition	addition	NOUN
admet-191	55	7	of	of	ADP
admet-191	55	8	selected	select	VERB
admet-191	55	9	heavy	heavy	ADJ
admet-191	55	10	metal	metal	NOUN
admet-191	55	11	ions	ion	NOUN
admet-191	55	12	(	(	PUNCT
admet-191	55	13	cu2	cu2	NOUN
admet-191	55	14	+	+	PROPN
admet-191	55	15	,	,	PUNCT
admet-191	55	16	zn2	zn2	PROPN
admet-191	55	17	+	+	NOUN
admet-191	55	18	and	and	CCONJ
admet-191	55	19	cd2	cd2	NOUN
admet-191	55	20	+	+	NOUN
admet-191	55	21	)	)	PUNCT
admet-191	55	22	to	to	ADP
admet-191	55	23	the	the	DET
admet-191	55	24	bacterial	bacterial	ADJ
admet-191	55	25	cultures	culture	NOUN
admet-191	55	26	procedure	procedure	NOUN
admet-191	55	27	for	for	ADP
admet-191	55	28	the	the	DET
admet-191	55	29	evaluation	evaluation	NOUN
admet-191	55	30	of	of	ADP
admet-191	55	31	the	the	DET
admet-191	55	32	antimicrobial	antimicrobial	ADJ
admet-191	55	33	effect	effect	NOUN
admet-191	55	34	of	of	ADP
admet-191	55	35	tested	test	VERB
admet-191	55	36	compounds	compound	NOUN
admet-191	55	37	and	and	CCONJ
admet-191	55	38	their	their	PRON
admet-191	55	39	combinations	combination	NOUN
admet-191	55	40	consisted	consist	VERB
admet-191	55	41	of	of	ADP
admet-191	55	42	measuring	measure	VERB
admet-191	55	43	the	the	DET
admet-191	55	44	absorbance	absorbance	NOUN
admet-191	55	45	using	use	VERB
admet-191	55	46	the	the	DET
admet-191	55	47	apparatus	apparatus	NOUN
admet-191	55	48	multiscan	multiscan	AUX
admet-191	55	49	ex	ex	X
admet-191	55	50	(	(	PUNCT
admet-191	55	51	thermo	thermo	NOUN
admet-191	55	52	fisher	fisher	PROPN
admet-191	55	53	scientific	scientific	PROPN
admet-191	55	54	,	,	PUNCT
admet-191	55	55	germany	germany	PROPN
admet-191	55	56	)	)	PUNCT
admet-191	55	57	and	and	CCONJ
admet-191	55	58	subsequent	subsequent	ADJ
admet-191	55	59	analysis	analysis	NOUN
admet-191	55	60	in	in	ADP
admet-191	55	61	the	the	DET
admet-191	55	62	form	form	NOUN
admet-191	55	63	of	of	ADP
admet-191	55	64	growth	growth	NOUN
admet-191	55	65	curves	curve	NOUN
admet-191	55	66	.	.	PUNCT
admet-191	56	1	control	control	VERB
admet-191	56	2	bacterial	bacterial	ADJ
admet-191	56	3	cultures	culture	NOUN
admet-191	56	4	of	of	ADP
admet-191	56	5	e.	e.	PROPN
admet-191	56	6	coli	coli	PROPN
admet-191	56	7	and	and	CCONJ
admet-191	56	8	e.	e.	PROPN
admet-191	56	9	coli	coli	PROPN
admet-191	56	10	with	with	ADP
admet-191	56	11	hmt-3	hmt-3	NOUN
admet-191	56	12	or	or	CCONJ
admet-191	56	13	hprp	hprp	PROPN
admet-191	56	14	c	c	PROPN
admet-191	56	15	were	be	AUX
admet-191	56	16	cultivated	cultivate	VERB
admet-191	56	17	in	in	ADP
admet-191	56	18	lb	lb	DET
admet-191	56	19	medium	medium	NOUN
admet-191	56	20	with	with	ADP
admet-191	56	21	50	50	NUM
admet-191	56	22	µg	µg	ADV
admet-191	56	23	ml	ml	NOUN
admet-191	56	24	-1	-1	INTJ
admet-191	56	25	ampicillin	ampicillin	PROPN
admet-191	56	26	,	,	PUNCT
admet-191	56	27	35	35	NUM
admet-191	56	28	µg	µg	ADV
admet-191	56	29	ml	ml	NOUN
admet-191	56	30	-1	-1	PUNCT
admet-191	56	31	chloramphenicol	chloramphenicol	NOUN
admet-191	56	32	and	and	CCONJ
admet-191	56	33	1	1	NUM
admet-191	56	34	mm	mm	NOUN
admet-191	56	35	iptg	iptg	NOUN
admet-191	56	36	for	for	ADP
admet-191	56	37	24	24	NUM
admet-191	56	38	hours	hour	NOUN
admet-191	56	39	with	with	ADP
admet-191	56	40	shaking	shake	VERB
admet-191	56	41	.	.	PUNCT
admet-191	57	1	in	in	ADP
admet-191	57	2	the	the	DET
admet-191	57	3	microplate	microplate	NOUN
admet-191	57	4	these	these	DET
admet-191	57	5	cultures	culture	NOUN
admet-191	57	6	were	be	AUX
admet-191	57	7	mixed	mix	VERB
admet-191	57	8	with	with	ADP
admet-191	57	9	cadmium	cadmium	NOUN
admet-191	57	10	,	,	PUNCT
admet-191	57	11	zinc	zinc	NOUN
admet-191	57	12	and	and	CCONJ
admet-191	57	13	copper	copper	NOUN
admet-191	57	14	ions	ion	NOUN
admet-191	57	15	(	(	PUNCT
admet-191	57	16	10	10	NUM
admet-191	57	17	,	,	PUNCT
admet-191	57	18	50	50	NUM
admet-191	57	19	,	,	PUNCT
admet-191	57	20	150	150	NUM
admet-191	57	21	and	and	CCONJ
admet-191	57	22	300	300	NUM
admet-191	57	23	µm	µm	ADP
admet-191	57	24	concentrations	concentration	NOUN
admet-191	57	25	)	)	PUNCT
admet-191	57	26	or	or	CCONJ
admet-191	57	27	strains	strain	VERB
admet-191	57	28	without	without	ADP
admet-191	57	29	addition	addition	NOUN
admet-191	57	30	of	of	ADP
admet-191	57	31	heavy	heavy	ADJ
admet-191	57	32	metal	metal	NOUN
admet-191	57	33	ions	ion	NOUN
admet-191	57	34	alone	alone	ADV
admet-191	57	35	as	as	ADP
admet-191	57	36	a	a	DET
admet-191	57	37	control	control	NOUN
admet-191	57	38	for	for	ADP
admet-191	57	39	measurements	measurement	NOUN
admet-191	57	40	.	.	PUNCT
admet-191	58	1	total	total	ADJ
admet-191	58	2	volume	volume	NOUN
admet-191	58	3	in	in	ADP
admet-191	58	4	the	the	DET
admet-191	58	5	microplate	microplate	PROPN
admet-191	58	6	wells	wells	PROPN
admet-191	58	7	was	be	AUX
admet-191	58	8	always	always	ADV
admet-191	58	9	300	300	NUM
admet-191	58	10	µl	µl	NOUN
admet-191	58	11	.	.	PUNCT
admet-191	59	1	measurements	measurement	NOUN
admet-191	59	2	were	be	AUX
admet-191	59	3	carried	carry	VERB
admet-191	59	4	out	out	ADP
admet-191	59	5	at	at	ADP
admet-191	59	6	time	time	NOUN
admet-191	59	7	0	0	NUM
admet-191	59	8	,	,	PUNCT
admet-191	59	9	then	then	ADV
admet-191	59	10	each	each	DET
admet-191	59	11	half	half	NOUN
admet-191	59	12	-	-	PUNCT
admet-191	59	13	hourly	hourly	ADJ
admet-191	59	14	for	for	ADP
admet-191	59	15	24	24	NUM
admet-191	59	16	hours	hour	NOUN
admet-191	59	17	at	at	ADP
admet-191	59	18	37	37	NUM
admet-191	59	19	°	°	ADP
admet-191	59	20	c	c	NOUN
admet-191	59	21	and	and	CCONJ
admet-191	59	22	a	a	DET
admet-191	59	23	wavelength	wavelength	NOUN
admet-191	59	24	of	of	ADP
admet-191	59	25	620	620	NUM
admet-191	59	26	nm	nm	NOUN
admet-191	59	27	.	.	PUNCT
admet-191	60	1	preparation	preparation	NOUN
admet-191	60	2	of	of	ADP
admet-191	60	3	samples	sample	NOUN
admet-191	60	4	each	each	DET
admet-191	60	5	sample	sample	NOUN
admet-191	60	6	(	(	PUNCT
admet-191	60	7	control	control	NOUN
admet-191	60	8	strains	strain	VERB
admet-191	60	9	–	–	PUNCT
admet-191	60	10	e.	e.	PROPN
admet-191	60	11	coli	coli	PROPN
admet-191	60	12	,	,	PUNCT
admet-191	60	13	e.	e.	PROPN
admet-191	60	14	coli	coli	PROPN
admet-191	60	15	–	–	PUNCT
admet-191	60	16	mt-3	mt-3	NUM
admet-191	60	17	,	,	PUNCT
admet-191	60	18	e.	e.	PROPN
admet-191	60	19	coli	coli	NOUN
admet-191	60	20	hprpc	hprpc	NOUN
admet-191	60	21	or	or	CCONJ
admet-191	60	22	strains	strain	NOUN
admet-191	60	23	with	with	ADP
admet-191	60	24	addition	addition	NOUN
admet-191	60	25	of	of	ADP
admet-191	60	26	10	10	NUM
admet-191	60	27	,	,	PUNCT
admet-191	60	28	25	25	NUM
admet-191	60	29	,	,	PUNCT
admet-191	60	30	50	50	NUM
admet-191	60	31	,	,	PUNCT
admet-191	60	32	75	75	NUM
admet-191	60	33	,	,	PUNCT
admet-191	60	34	150	150	NUM
admet-191	60	35	and	and	CCONJ
admet-191	60	36	300	300	NUM
admet-191	60	37	µm	µm	ADP
admet-191	60	38	concentrations	concentration	NOUN
admet-191	60	39	of	of	ADP
admet-191	60	40	cu2	cu2	NOUN
admet-191	60	41	+	+	PROPN
admet-191	60	42	,	,	PUNCT
admet-191	60	43	zn2	zn2	PROPN
admet-191	60	44	+	+	NOUN
admet-191	60	45	and	and	CCONJ
admet-191	60	46	cd2	cd2	PROPN
admet-191	60	47	+	+	NOUN
admet-191	60	48	ions	ion	NOUN
admet-191	60	49	)	)	PUNCT
admet-191	60	50	was	be	AUX
admet-191	60	51	centrifuged	centrifuge	VERB
admet-191	60	52	at	at	ADP
admet-191	60	53	8000	8000	NUM
admet-191	60	54	rpm	rpm	NOUN
admet-191	60	55	for	for	ADP
admet-191	60	56	10	10	NUM
admet-191	60	57	minutes	minute	NOUN
admet-191	60	58	.	.	PUNCT
admet-191	61	1	liquid	liquid	ADJ
admet-191	61	2	nitrogen	nitrogen	NOUN
admet-191	61	3	was	be	AUX
admet-191	61	4	added	add	VERB
admet-191	61	5	to	to	ADP
admet-191	61	6	the	the	DET
admet-191	61	7	pellet	pellet	NOUN
admet-191	61	8	.	.	PUNCT
admet-191	62	1	after	after	ADP
admet-191	62	2	evaporation	evaporation	NOUN
admet-191	62	3	,	,	PUNCT
admet-191	62	4	1	1	NUM
admet-191	62	5	ml	ml	NOUN
admet-191	62	6	of	of	ADP
admet-191	62	7	phosphate	phosphate	ADJ
admet-191	62	8	buffer	buffer	NOUN
admet-191	62	9	(	(	PUNCT
admet-191	62	10	ph	ph	NOUN
admet-191	62	11	7	7	NUM
admet-191	62	12	)	)	PUNCT
admet-191	62	13	was	be	AUX
admet-191	62	14	added	add	VERB
admet-191	62	15	and	and	CCONJ
admet-191	62	16	samples	sample	NOUN
admet-191	62	17	were	be	AUX
admet-191	62	18	mixed	mix	VERB
admet-191	62	19	for	for	ADP
admet-191	62	20	30	30	NUM
admet-191	62	21	minutes	minute	NOUN
admet-191	62	22	.	.	PUNCT
admet-191	63	1	two	two	NUM
admet-191	63	2	minutes	minute	NOUN
admet-191	63	3	of	of	ADP
admet-191	63	4	ultrasound	ultrasound	NOUN
admet-191	63	5	were	be	AUX
admet-191	63	6	used	use	VERB
admet-191	63	7	for	for	ADP
admet-191	63	8	the	the	DET
admet-191	63	9	lysis	lysis	NOUN
admet-191	63	10	of	of	ADP
admet-191	63	11	cells	cell	NOUN
admet-191	63	12	.	.	PUNCT
admet-191	64	1	after	after	ADP
admet-191	64	2	centrifugation	centrifugation	NOUN
admet-191	64	3	at	at	ADP
admet-191	64	4	8000	8000	NUM
admet-191	64	5	rpm	rpm	NOUN
admet-191	64	6	for	for	ADP
admet-191	64	7	10	10	NUM
admet-191	64	8	minutes	minute	NOUN
admet-191	64	9	,	,	PUNCT
admet-191	64	10	the	the	DET
admet-191	64	11	supernatant	supernatant	NOUN
admet-191	64	12	was	be	AUX
admet-191	64	13	used	use	VERB
admet-191	64	14	in	in	ADP
admet-191	64	15	the	the	DET
admet-191	64	16	following	follow	VERB
admet-191	64	17	experiments	experiment	NOUN
admet-191	64	18	.	.	PUNCT
admet-191	65	1	for	for	ADP
admet-191	65	2	electrochemical	electrochemical	ADJ
admet-191	65	3	measurements	measurement	NOUN
admet-191	65	4	25	25	NUM
admet-191	65	5	,	,	PUNCT
admet-191	65	6	50	50	NUM
admet-191	65	7	,	,	PUNCT
admet-191	65	8	75	75	NUM
admet-191	65	9	,	,	PUNCT
admet-191	65	10	and	and	CCONJ
admet-191	65	11	150	150	NUM
admet-191	65	12	µm	µm	NOUN
admet-191	65	13	of	of	ADP
admet-191	65	14	metal	metal	NOUN
admet-191	65	15	ions	ion	NOUN
admet-191	65	16	were	be	AUX
admet-191	65	17	used	use	VERB
admet-191	65	18	.	.	PUNCT
admet-191	66	1	electrochemical	electrochemical	ADJ
admet-191	66	2	measurement	measurement	NOUN
admet-191	66	3	of	of	ADP
admet-191	66	4	metallothionein	metallothionein	ADJ
admet-191	66	5	by	by	ADP
admet-191	66	6	differential	differential	ADJ
admet-191	66	7	pulse	pulse	NOUN
admet-191	66	8	voltammetry	voltammetry	NOUN
admet-191	66	9	differential	differential	PROPN
admet-191	66	10	pulse	pulse	NOUN
admet-191	66	11	voltammetric	voltammetric	ADJ
admet-191	66	12	measurements	measurement	NOUN
admet-191	66	13	were	be	AUX
admet-191	66	14	performed	perform	VERB
admet-191	66	15	with	with	ADP
admet-191	66	16	747	747	NUM
admet-191	66	17	va	va	NOUN
admet-191	66	18	stand	stand	NOUN
admet-191	66	19	instrument	instrument	NOUN
admet-191	66	20	connected	connect	VERB
admet-191	66	21	to	to	ADP
admet-191	66	22	693	693	NUM
admet-191	66	23	va	va	NOUN
admet-191	66	24	processor	processor	NOUN
admet-191	66	25	and	and	CCONJ
admet-191	66	26	695	695	NUM
admet-191	66	27	autosampler	autosampler	NOUN
admet-191	66	28	(	(	PUNCT
admet-191	66	29	metrohm	metrohm	PROPN
admet-191	66	30	,	,	PUNCT
admet-191	66	31	switzerland	switzerland	PROPN
admet-191	66	32	)	)	PUNCT
admet-191	66	33	,	,	PUNCT
admet-191	66	34	using	use	VERB
admet-191	66	35	a	a	DET
admet-191	66	36	standard	standard	ADJ
admet-191	66	37	cell	cell	NOUN
admet-191	66	38	with	with	ADP
admet-191	66	39	three	three	NUM
admet-191	66	40	electrodes	electrode	NOUN
admet-191	66	41	,	,	PUNCT
admet-191	66	42	a	a	DET
admet-191	66	43	cooled	cool	VERB
admet-191	66	44	sample	sample	NOUN
admet-191	66	45	holder	holder	NOUN
admet-191	66	46	,	,	PUNCT
admet-191	66	47	and	and	CCONJ
admet-191	66	48	measurement	measurement	NOUN
admet-191	66	49	cell	cell	NOUN
admet-191	66	50	cooled	cool	VERB
admet-191	66	51	to	to	ADP
admet-191	66	52	4	4	NUM
admet-191	66	53	°	°	NOUN
admet-191	66	54	c	c	NOUN
admet-191	66	55	(	(	PUNCT
admet-191	66	56	julabo	julabo	PROPN
admet-191	66	57	f25	f25	PROPN
admet-191	66	58	,	,	PUNCT
admet-191	66	59	germany	germany	PROPN
admet-191	66	60	)	)	PUNCT
admet-191	66	61	.	.	PUNCT
admet-191	67	1	a	a	DET
admet-191	67	2	ruttkay	ruttkay	ADJ
admet-191	67	3	-	-	PUNCT
admet-191	67	4	nedecky	nedecky	ADJ
admet-191	67	5	et	et	PROPN
admet-191	67	6	al	al	PROPN
admet-191	67	7	.	.	PROPN
admet-191	67	8	admet	admet	PROPN
admet-191	67	9	&	&	CCONJ
admet-191	67	10	dmpk	dmpk	PROPN
admet-191	67	11	3(3	3(3	NUM
admet-191	67	12	)	)	PUNCT
admet-191	67	13	(	(	PUNCT
admet-191	67	14	2015	2015	NUM
admet-191	67	15	)	)	PUNCT
admet-191	67	16	287	287	NUM
admet-191	67	17	-	-	SYM
admet-191	67	18	295	295	NUM
admet-191	67	19	290	290	NUM
admet-191	67	20	hanging	hang	VERB
admet-191	67	21	mercury	mercury	NOUN
admet-191	67	22	drop	drop	NOUN
admet-191	67	23	electrode	electrode	NOUN
admet-191	67	24	(	(	PUNCT
admet-191	67	25	hmde	hmde	NOUN
admet-191	67	26	)	)	PUNCT
admet-191	67	27	with	with	ADP
admet-191	67	28	a	a	DET
admet-191	67	29	drop	drop	NOUN
admet-191	67	30	area	area	NOUN
admet-191	67	31	of	of	ADP
admet-191	67	32	0.4	0.4	NUM
admet-191	67	33	mm	mm	NOUN
admet-191	67	34	2	2	NUM
admet-191	67	35	was	be	AUX
admet-191	67	36	the	the	DET
admet-191	67	37	working	work	VERB
admet-191	67	38	electrode	electrode	NOUN
admet-191	67	39	.	.	PUNCT
admet-191	68	1	an	an	DET
admet-191	68	2	ag	ag	PROPN
admet-191	68	3	/	/	SYM
admet-191	68	4	agcl/3	agcl/3	PROPN
admet-191	68	5	m	m	NOUN
admet-191	68	6	kcl	kcl	ADJ
admet-191	68	7	electrode	electrode	NOUN
admet-191	68	8	was	be	AUX
admet-191	68	9	the	the	DET
admet-191	68	10	reference	reference	NOUN
admet-191	68	11	and	and	CCONJ
admet-191	68	12	platinum	platinum	NOUN
admet-191	68	13	electrode	electrode	NOUN
admet-191	68	14	was	be	AUX
admet-191	68	15	auxiliary	auxiliary	ADJ
admet-191	68	16	.	.	PUNCT
admet-191	69	1	for	for	ADP
admet-191	69	2	data	data	NOUN
admet-191	69	3	processing	processing	NOUN
admet-191	69	4	va	va	PROPN
admet-191	69	5	database	database	NOUN
admet-191	69	6	2.2	2.2	NUM
admet-191	69	7	by	by	ADP
admet-191	69	8	metrohm	metrohm	PROPN
admet-191	69	9	ch	ch	PROPN
admet-191	69	10	was	be	AUX
admet-191	69	11	employed	employ	VERB
admet-191	69	12	.	.	PUNCT
admet-191	70	1	the	the	DET
admet-191	70	2	analysed	analyse	VERB
admet-191	70	3	samples	sample	NOUN
admet-191	70	4	were	be	AUX
admet-191	70	5	deoxygenated	deoxygenate	VERB
admet-191	70	6	prior	prior	ADV
admet-191	70	7	to	to	ADP
admet-191	70	8	measurements	measurement	NOUN
admet-191	70	9	by	by	ADP
admet-191	70	10	purging	purge	VERB
admet-191	70	11	with	with	ADP
admet-191	70	12	argon	argon	NOUN
admet-191	70	13	(	(	PUNCT
admet-191	70	14	99.999	99.999	NUM
admet-191	70	15	%	%	NOUN
admet-191	70	16	)	)	PUNCT
admet-191	70	17	saturated	saturate	VERB
admet-191	70	18	with	with	ADP
admet-191	70	19	water	water	NOUN
admet-191	70	20	for	for	ADP
admet-191	70	21	120	120	NUM
admet-191	70	22	s.	s.	PROPN
admet-191	70	23	brdička	brdička	PROPN
admet-191	70	24	supporting	support	VERB
admet-191	70	25	electrolyte	electrolyte	NOUN
admet-191	70	26	containing	contain	VERB
admet-191	70	27	1	1	NUM
admet-191	70	28	mm	mm	PROPN
admet-191	70	29	co(nh3)6cl3	co(nh3)6cl3	PROPN
admet-191	70	30	and	and	CCONJ
admet-191	70	31	1	1	NUM
admet-191	70	32	m	m	NOUN
admet-191	70	33	ammonia	ammonia	NOUN
admet-191	70	34	buffer	buffer	NOUN
admet-191	70	35	(	(	PUNCT
admet-191	70	36	nh3(aq	nh3(aq	PROPN
admet-191	70	37	)	)	PUNCT
admet-191	71	1	+	+	SYM
admet-191	71	2	nh4cl	nh4cl	NUM
admet-191	71	3	,	,	PUNCT
admet-191	71	4	ph	ph	NOUN
admet-191	71	5	=	=	SYM
admet-191	71	6	9.6	9.6	NUM
admet-191	71	7	)	)	PUNCT
admet-191	71	8	was	be	AUX
admet-191	71	9	used	use	VERB
admet-191	71	10	.	.	PUNCT
admet-191	72	1	the	the	DET
admet-191	72	2	supporting	support	VERB
admet-191	72	3	electrolyte	electrolyte	NOUN
admet-191	72	4	was	be	AUX
admet-191	72	5	exchanged	exchange	VERB
admet-191	72	6	after	after	ADP
admet-191	72	7	each	each	DET
admet-191	72	8	analysis	analysis	NOUN
admet-191	72	9	.	.	PUNCT
admet-191	73	1	the	the	DET
admet-191	73	2	parameters	parameter	NOUN
admet-191	73	3	of	of	ADP
admet-191	73	4	the	the	DET
admet-191	73	5	measurement	measurement	NOUN
admet-191	73	6	were	be	AUX
admet-191	73	7	as	as	SCONJ
admet-191	73	8	follows	follow	VERB
admet-191	73	9	:	:	PUNCT
admet-191	73	10	initial	initial	ADJ
admet-191	73	11	potential	potential	NOUN
admet-191	73	12	of	of	ADP
admet-191	73	13	-0.700	-0.700	NOUN
admet-191	73	14	v	v	NOUN
admet-191	73	15	,	,	PUNCT
admet-191	73	16	end	end	VERB
admet-191	73	17	potential	potential	NOUN
admet-191	73	18	of	of	ADP
admet-191	73	19	-1.750	-1.750	PUNCT
admet-191	73	20	v	v	NOUN
admet-191	73	21	,	,	PUNCT
admet-191	73	22	modulation	modulation	NOUN
admet-191	73	23	time	time	NOUN
admet-191	73	24	0.057	0.057	NUM
admet-191	73	25	s	s	NOUN
admet-191	73	26	,	,	PUNCT
admet-191	73	27	time	time	NOUN
admet-191	73	28	interval	interval	NOUN
admet-191	73	29	0.2	0.2	NUM
admet-191	73	30	s	s	PROPN
admet-191	73	31	,	,	PUNCT
admet-191	73	32	step	step	VERB
admet-191	73	33	potential	potential	ADJ
admet-191	73	34	0.002	0.002	NUM
admet-191	73	35	v	v	NOUN
admet-191	73	36	,	,	PUNCT
admet-191	73	37	modulation	modulation	NOUN
admet-191	73	38	amplitude	amplitude	NOUN
admet-191	73	39	-0.250	-0.250	NUM
admet-191	73	40	v	v	NOUN
admet-191	73	41	,	,	PUNCT
admet-191	73	42	eads	eads	PROPN
admet-191	73	43	=	=	SYM
admet-191	73	44	0	0	NUM
admet-191	73	45	v	v	NOUN
admet-191	73	46	,	,	PUNCT
admet-191	73	47	volume	volume	NOUN
admet-191	73	48	of	of	ADP
admet-191	73	49	injected	inject	VERB
admet-191	73	50	sample	sample	NOUN
admet-191	73	51	:	:	PUNCT
admet-191	73	52	20	20	NUM
admet-191	73	53	µl	µl	NOUN
admet-191	73	54	,	,	PUNCT
admet-191	73	55	volume	volume	NOUN
admet-191	73	56	of	of	ADP
admet-191	73	57	measurement	measurement	NOUN
admet-191	73	58	cell	cell	NOUN
admet-191	73	59	2	2	NUM
admet-191	73	60	ml	ml	NOUN
admet-191	73	61	(	(	PUNCT
admet-191	73	62	20	20	NUM
admet-191	73	63	μl	μl	NOUN
admet-191	73	64	of	of	ADP
admet-191	73	65	sample	sample	NOUN
admet-191	73	66	and	and	CCONJ
admet-191	73	67	1980	1980	NUM
admet-191	73	68	µl	µl	ADP
admet-191	73	69	brdicka	brdicka	NOUN
admet-191	73	70	solution	solution	NOUN
admet-191	73	71	)	)	PUNCT
admet-191	73	72	for	for	ADP
admet-191	73	73	calibration	calibration	NOUN
admet-191	73	74	curves	curve	NOUN
admet-191	73	75	.	.	PUNCT
admet-191	74	1	for	for	ADP
admet-191	74	2	calibration	calibration	NOUN
admet-191	74	3	curve	curve	NOUN
admet-191	74	4	measurements	measurement	NOUN
admet-191	74	5	mt2a	mt2a	PROPN
admet-191	74	6	standard	standard	NOUN
admet-191	74	7	(	(	PUNCT
admet-191	74	8	ikzus	ikzus	NOUN
admet-191	74	9	proteomics	proteomic	NOUN
admet-191	74	10	,	,	PUNCT
admet-191	74	11	italy	italy	PROPN
admet-191	74	12	)	)	PUNCT
admet-191	74	13	was	be	AUX
admet-191	74	14	used	use	VERB
admet-191	74	15	.	.	PUNCT
admet-191	75	1	the	the	DET
admet-191	75	2	volume	volume	NOUN
admet-191	75	3	for	for	ADP
admet-191	75	4	the	the	DET
admet-191	75	5	measurement	measurement	NOUN
admet-191	75	6	of	of	ADP
admet-191	75	7	bacterial	bacterial	ADJ
admet-191	75	8	culture	culture	NOUN
admet-191	75	9	of	of	ADP
admet-191	75	10	e.	e.	PROPN
admet-191	75	11	coli	coli	PROPN
admet-191	75	12	and	and	CCONJ
admet-191	75	13	e.	e.	PROPN
admet-191	75	14	coli	coli	PROPN
admet-191	75	15	with	with	ADP
admet-191	75	16	mt-3	mt-3	NOUN
admet-191	75	17	or	or	CCONJ
admet-191	75	18	hprpc	hprpc	NOUN
admet-191	75	19	with	with	ADP
admet-191	75	20	metals	metal	NOUN
admet-191	75	21	was	be	AUX
admet-191	75	22	100	100	NUM
admet-191	75	23	µl	µl	ADP
admet-191	75	24	of	of	ADP
admet-191	75	25	bacterial	bacterial	ADJ
admet-191	75	26	culture	culture	NOUN
admet-191	75	27	and	and	CCONJ
admet-191	75	28	1900	1900	NUM
admet-191	75	29	µl	µl	NOUN
admet-191	75	30	of	of	ADP
admet-191	75	31	brdicka	brdicka	NOUN
admet-191	75	32	solution	solution	NOUN
admet-191	75	33	.	.	PUNCT
admet-191	76	1	statistical	statistical	ADJ
admet-191	76	2	analyses	analysis	NOUN
admet-191	76	3	software	software	NOUN
admet-191	76	4	statistica	statistica	PROPN
admet-191	76	5	(	(	PUNCT
admet-191	76	6	data	datum	NOUN
admet-191	76	7	analysis	analysis	NOUN
admet-191	76	8	software	software	NOUN
admet-191	76	9	system	system	NOUN
admet-191	76	10	)	)	PUNCT
admet-191	76	11	version	version	NOUN
admet-191	76	12	10.0	10.0	NUM
admet-191	76	13	(	(	PUNCT
admet-191	76	14	tulsa	tulsa	PROPN
admet-191	76	15	,	,	PUNCT
admet-191	76	16	oklahoma	oklahoma	PROPN
admet-191	76	17	,	,	PUNCT
admet-191	76	18	usa	usa	PROPN
admet-191	76	19	)	)	PUNCT
admet-191	76	20	was	be	AUX
admet-191	76	21	used	use	VERB
admet-191	76	22	for	for	ADP
admet-191	76	23	data	data	NOUN
admet-191	76	24	processing	processing	NOUN
admet-191	76	25	.	.	PUNCT
admet-191	77	1	half	half	ADJ
admet-191	77	2	-	-	PUNCT
admet-191	77	3	maximal	maximal	ADJ
admet-191	77	4	concentrations	concentration	NOUN
admet-191	77	5	(	(	PUNCT
admet-191	77	6	ic50	ic50	PROPN
admet-191	77	7	)	)	PUNCT
admet-191	77	8	were	be	AUX
admet-191	77	9	calculated	calculate	VERB
admet-191	77	10	from	from	ADP
admet-191	77	11	logarithmic	logarithmic	ADJ
admet-191	77	12	regression	regression	NOUN
admet-191	77	13	of	of	ADP
admet-191	77	14	sigmoidal	sigmoidal	NOUN
admet-191	77	15	dose	dose	NOUN
admet-191	77	16	-	-	PUNCT
admet-191	77	17	response	response	NOUN
admet-191	77	18	curve	curve	NOUN
admet-191	77	19	.	.	PUNCT
admet-191	78	1	general	general	ADJ
admet-191	78	2	regression	regression	NOUN
admet-191	78	3	model	model	NOUN
admet-191	78	4	was	be	AUX
admet-191	78	5	used	use	VERB
admet-191	78	6	to	to	PART
admet-191	78	7	analyse	analyse	VERB
admet-191	78	8	differences	difference	NOUN
admet-191	78	9	between	between	ADP
admet-191	78	10	the	the	DET
admet-191	78	11	combinations	combination	NOUN
admet-191	78	12	of	of	ADP
admet-191	78	13	compounds	compound	NOUN
admet-191	78	14	.	.	PUNCT
admet-191	79	1	to	to	PART
admet-191	79	2	reveal	reveal	VERB
admet-191	79	3	the	the	DET
admet-191	79	4	differences	difference	NOUN
admet-191	79	5	between	between	ADP
admet-191	79	6	cell	cell	NOUN
admet-191	79	7	lines	line	NOUN
admet-191	79	8	,	,	PUNCT
admet-191	79	9	tukey	tukey	PROPN
admet-191	79	10	’s	’s	PART
admet-191	79	11	post	post	X
admet-191	79	12	hoc	hoc	X
admet-191	79	13	test	test	NOUN
admet-191	79	14	within	within	ADP
admet-191	79	15	homogenous	homogenous	ADJ
admet-191	79	16	groups	group	NOUN
admet-191	79	17	and	and	CCONJ
admet-191	79	18	also	also	ADV
admet-191	79	19	f	f	X
admet-191	79	20	-	-	PUNCT
admet-191	79	21	test	test	NOUN
admet-191	79	22	was	be	AUX
admet-191	79	23	employed	employ	VERB
admet-191	79	24	.	.	PUNCT
admet-191	80	1	unless	unless	SCONJ
admet-191	80	2	noted	note	VERB
admet-191	80	3	otherwise	otherwise	ADV
admet-191	80	4	,	,	PUNCT
admet-191	80	5	p	p	X
admet-191	80	6	<	<	X
admet-191	80	7	0.05	0.05	NUM
admet-191	80	8	was	be	AUX
admet-191	80	9	considered	consider	VERB
admet-191	80	10	significant	significant	ADJ
admet-191	80	11	.	.	PUNCT
admet-191	81	1	data	datum	NOUN
admet-191	81	2	from	from	ADP
admet-191	81	3	3	3	NUM
admet-191	81	4	measurements	measurement	NOUN
admet-191	81	5	were	be	AUX
admet-191	81	6	analysed	analyse	VERB
admet-191	81	7	.	.	PUNCT
admet-191	82	1	results	result	NOUN
admet-191	82	2	and	and	CCONJ
admet-191	82	3	discussion	discussion	NOUN
admet-191	82	4	the	the	DET
admet-191	82	5	aim	aim	NOUN
admet-191	82	6	of	of	ADP
admet-191	82	7	this	this	DET
admet-191	82	8	study	study	NOUN
admet-191	82	9	was	be	AUX
admet-191	82	10	to	to	PART
admet-191	82	11	determine	determine	VERB
admet-191	82	12	the	the	DET
admet-191	82	13	effect	effect	NOUN
admet-191	82	14	of	of	ADP
admet-191	82	15	copper	copper	NOUN
admet-191	82	16	,	,	PUNCT
admet-191	82	17	zinc	zinc	NOUN
admet-191	82	18	and	and	CCONJ
admet-191	82	19	cadmium	cadmium	NOUN
admet-191	82	20	ions	ion	NOUN
admet-191	82	21	on	on	ADP
admet-191	82	22	metallothionein	metallothionein	ADJ
admet-191	82	23	level	level	NOUN
admet-191	82	24	and	and	CCONJ
admet-191	82	25	on	on	ADP
admet-191	82	26	the	the	DET
admet-191	82	27	growth	growth	NOUN
admet-191	82	28	of	of	ADP
admet-191	82	29	two	two	NUM
admet-191	82	30	different	different	ADJ
admet-191	82	31	e.	e.	PROPN
admet-191	82	32	coli	coli	PROPN
admet-191	82	33	bacterial	bacterial	ADJ
admet-191	82	34	cultures	culture	NOUN
admet-191	82	35	transformed	transform	VERB
admet-191	82	36	with	with	ADP
admet-191	82	37	the	the	DET
admet-191	82	38	plasmid	plasmid	NOUN
admet-191	82	39	containing	contain	VERB
admet-191	82	40	hprp	hprp	PROPN
admet-191	82	41	c	c	PROPN
admet-191	82	42	or	or	CCONJ
admet-191	82	43	mt-3	mt-3	NOUN
admet-191	82	44	gene	gene	NOUN
admet-191	82	45	,	,	PUNCT
admet-191	82	46	and	and	CCONJ
admet-191	82	47	control	control	PROPN
admet-191	82	48	e.	e.	PROPN
admet-191	82	49	coli	coli	PROPN
admet-191	82	50	(	(	PUNCT
admet-191	82	51	bl21(de3	bl21(de3	NOUN
admet-191	82	52	)	)	PUNCT
admet-191	82	53	)	)	PUNCT
admet-191	82	54	strain	strain	NOUN
admet-191	82	55	.	.	PUNCT
admet-191	83	1	proteins	protein	NOUN
admet-191	83	2	prp	prp	NOUN
admet-191	83	3	c	c	PROPN
admet-191	83	4	and	and	CCONJ
admet-191	83	5	mt-3	mt-3	NOUN
admet-191	83	6	are	be	AUX
admet-191	83	7	able	able	ADJ
admet-191	83	8	to	to	PART
admet-191	83	9	bind	bind	VERB
admet-191	83	10	heavy	heavy	ADJ
admet-191	83	11	metals	metal	NOUN
admet-191	83	12	,	,	PUNCT
admet-191	83	13	thus	thus	ADV
admet-191	83	14	protecting	protect	VERB
admet-191	83	15	cells	cell	NOUN
admet-191	83	16	from	from	ADP
admet-191	83	17	their	their	PRON
admet-191	83	18	toxicity	toxicity	NOUN
admet-191	83	19	and	and	CCONJ
admet-191	83	20	we	we	PRON
admet-191	83	21	attempted	attempt	VERB
admet-191	83	22	to	to	PART
admet-191	83	23	test	test	VERB
admet-191	83	24	this	this	DET
admet-191	83	25	hypothesis	hypothesis	NOUN
admet-191	83	26	by	by	ADP
admet-191	83	27	the	the	DET
admet-191	83	28	mentioned	mention	VERB
admet-191	83	29	experiments	experiment	NOUN
admet-191	83	30	.	.	PUNCT
admet-191	84	1	verification	verification	NOUN
admet-191	84	2	of	of	ADP
admet-191	84	3	the	the	DET
admet-191	84	4	expression	expression	NOUN
admet-191	84	5	of	of	ADP
admet-191	84	6	recombinant	recombinant	ADJ
admet-191	84	7	human	human	ADJ
admet-191	84	8	prion	prion	NOUN
admet-191	84	9	protein	protein	NOUN
admet-191	84	10	(	(	PUNCT
admet-191	84	11	hprpc	hprpc	NOUN
admet-191	84	12	)	)	PUNCT
admet-191	84	13	and	and	CCONJ
admet-191	84	14	metallothionein	metallothionein	ADJ
admet-191	84	15	3	3	NUM
admet-191	84	16	(	(	PUNCT
admet-191	84	17	mt-3	mt-3	NOUN
admet-191	84	18	)	)	PUNCT
admet-191	84	19	using	use	VERB
admet-191	84	20	western	western	ADJ
admet-191	84	21	-	-	PUNCT
admet-191	84	22	blot	blot	NOUN
admet-191	84	23	the	the	DET
admet-191	84	24	presence	presence	NOUN
admet-191	84	25	of	of	ADP
admet-191	84	26	the	the	DET
admet-191	84	27	hprpc	hprpc	NOUN
admet-191	84	28	expression	expression	NOUN
admet-191	84	29	was	be	AUX
admet-191	84	30	verified	verify	VERB
admet-191	84	31	using	use	VERB
admet-191	84	32	western	western	ADJ
admet-191	84	33	-	-	PUNCT
admet-191	84	34	blot	blot	NOUN
admet-191	84	35	(	(	PUNCT
admet-191	84	36	fig	fig	NOUN
admet-191	84	37	.	.	PUNCT
admet-191	85	1	2	2	NUM
admet-191	85	2	)	)	PUNCT
admet-191	85	3	.	.	PUNCT
admet-191	86	1	to	to	PART
admet-191	86	2	achieve	achieve	VERB
admet-191	86	3	better	well	ADJ
admet-191	86	4	production	production	NOUN
admet-191	86	5	and	and	CCONJ
admet-191	86	6	stimulation	stimulation	NOUN
admet-191	86	7	of	of	ADP
admet-191	86	8	proteins	protein	NOUN
admet-191	86	9	in	in	ADP
admet-191	86	10	bacterial	bacterial	ADJ
admet-191	86	11	cells	cell	NOUN
admet-191	86	12	iptg	iptg	NOUN
admet-191	87	1	(	(	PUNCT
admet-191	87	2	isopropyl	isopropyl	NOUN
admet-191	87	3	β	β	NOUN
admet-191	87	4	-	-	PUNCT
admet-191	87	5	d-1	d-1	NOUN
admet-191	87	6	-	-	PUNCT
admet-191	87	7	thiogalactopyranoside	thiogalactopyranoside	NOUN
admet-191	87	8	)	)	PUNCT
admet-191	87	9	was	be	AUX
admet-191	87	10	added	add	VERB
admet-191	87	11	to	to	ADP
admet-191	87	12	culture	culture	NOUN
admet-191	87	13	.	.	PUNCT
admet-191	88	1	bacterial	bacterial	ADJ
admet-191	88	2	cells	cell	NOUN
admet-191	88	3	,	,	PUNCT
admet-191	88	4	which	which	PRON
admet-191	88	5	were	be	AUX
admet-191	88	6	expressing	express	VERB
admet-191	88	7	hprpc	hprpc	NOUN
admet-191	88	8	protein	protein	NOUN
admet-191	88	9	,	,	PUNCT
admet-191	88	10	were	be	AUX
admet-191	88	11	divided	divide	VERB
admet-191	88	12	into	into	ADP
admet-191	88	13	pellet	pellet	NOUN
admet-191	88	14	and	and	CCONJ
admet-191	88	15	supernatant	supernatant	NOUN
admet-191	88	16	after	after	ADP
admet-191	88	17	lysis	lysis	NOUN
admet-191	88	18	and	and	CCONJ
admet-191	88	19	subsequent	subsequent	ADJ
admet-191	88	20	centrifugation	centrifugation	NOUN
admet-191	88	21	.	.	PUNCT
admet-191	89	1	after	after	ADP
admet-191	89	2	electrophoretic	electrophoretic	ADJ
admet-191	89	3	separation	separation	NOUN
admet-191	89	4	by	by	ADP
admet-191	89	5	sds	sds	PROPN
admet-191	89	6	-	-	PUNCT
admet-191	89	7	page	page	NOUN
admet-191	89	8	(	(	PUNCT
admet-191	89	9	fig	fig	NOUN
admet-191	89	10	.	.	PUNCT
admet-191	89	11	2a	2a	NUM
admet-191	89	12	)	)	PUNCT
admet-191	89	13	,	,	PUNCT
admet-191	89	14	the	the	DET
admet-191	89	15	proteins	protein	NOUN
admet-191	89	16	were	be	AUX
admet-191	89	17	transferred	transfer	VERB
admet-191	89	18	to	to	ADP
admet-191	89	19	a	a	DET
admet-191	89	20	nylon	nylon	NOUN
admet-191	89	21	membrane	membrane	NOUN
admet-191	89	22	where	where	SCONJ
admet-191	89	23	they	they	PRON
admet-191	89	24	were	be	AUX
admet-191	89	25	detected	detect	VERB
admet-191	89	26	with	with	ADP
admet-191	89	27	antibodies	antibody	NOUN
admet-191	89	28	against	against	ADP
admet-191	89	29	hprpc	hprpc	NOUN
admet-191	89	30	protein	protein	NOUN
admet-191	89	31	.	.	PUNCT
admet-191	90	1	positive	positive	ADJ
admet-191	90	2	band	band	NOUN
admet-191	90	3	of	of	ADP
admet-191	90	4	hprpc	hprpc	NOUN
admet-191	90	5	protein	protein	NOUN
admet-191	90	6	with	with	ADP
admet-191	90	7	size	size	NOUN
admet-191	90	8	of	of	ADP
admet-191	90	9	about	about	ADV
admet-191	90	10	20	20	NUM
admet-191	90	11	kda	kda	NOUN
admet-191	90	12	was	be	AUX
admet-191	90	13	detected	detect	VERB
admet-191	90	14	in	in	ADP
admet-191	90	15	the	the	DET
admet-191	90	16	pellet	pellet	NOUN
admet-191	90	17	of	of	ADP
admet-191	90	18	bacterial	bacterial	ADJ
admet-191	90	19	cells	cell	NOUN
admet-191	90	20	in	in	ADP
admet-191	90	21	a	a	DET
admet-191	90	22	sample	sample	NOUN
admet-191	90	23	with	with	ADP
admet-191	90	24	the	the	DET
admet-191	90	25	addition	addition	NOUN
admet-191	90	26	of	of	ADP
admet-191	90	27	iptg	iptg	NOUN
admet-191	90	28	only	only	ADV
admet-191	90	29	.	.	PUNCT
admet-191	91	1	this	this	DET
admet-191	91	2	finding	finding	NOUN
admet-191	91	3	can	can	AUX
admet-191	91	4	be	be	AUX
admet-191	91	5	explained	explain	VERB
admet-191	91	6	by	by	ADP
admet-191	91	7	possible	possible	ADJ
admet-191	91	8	aggregation	aggregation	NOUN
admet-191	91	9	and	and	CCONJ
admet-191	91	10	crystallization	crystallization	NOUN
admet-191	91	11	of	of	ADP
admet-191	91	12	hprpc	hprpc	NOUN
admet-191	91	13	in	in	ADP
admet-191	91	14	pellet	pellet	NOUN
admet-191	91	15	(	(	PUNCT
admet-191	91	16	fig	fig	NOUN
admet-191	91	17	.	.	PUNCT
admet-191	91	18	2b	2b	NUM
admet-191	91	19	)	)	PUNCT
admet-191	91	20	.	.	PUNCT
admet-191	92	1	these	these	DET
admet-191	92	2	results	result	NOUN
admet-191	92	3	were	be	AUX
admet-191	92	4	also	also	ADV
admet-191	92	5	confirmed	confirm	VERB
admet-191	92	6	by	by	ADP
admet-191	92	7	dot	dot	NOUN
admet-191	92	8	-	-	PUNCT
admet-191	92	9	blot	blot	NOUN
admet-191	92	10	(	(	PUNCT
admet-191	92	11	not	not	PART
admet-191	92	12	shown	show	VERB
admet-191	92	13	)	)	PUNCT
admet-191	92	14	.	.	PUNCT
admet-191	93	1	admet	admet	PROPN
admet-191	93	2	&	&	CCONJ
admet-191	93	3	dmpk	dmpk	PROPN
admet-191	93	4	3(3	3(3	NUM
admet-191	93	5	)	)	PUNCT
admet-191	93	6	(	(	PUNCT
admet-191	93	7	2015	2015	NUM
admet-191	93	8	)	)	PUNCT
admet-191	93	9	287	287	NUM
admet-191	93	10	-	-	SYM
admet-191	93	11	295	295	NUM
admet-191	93	12	prion	prion	NOUN
admet-191	93	13	interactions	interaction	NOUN
admet-191	93	14	with	with	ADP
admet-191	93	15	metals	metal	NOUN
admet-191	93	16	and	and	CCONJ
admet-191	93	17	metallothionein	metallothionein	ADJ
admet-191	93	18	doi	doi	PROPN
admet-191	93	19	:	:	PUNCT
admet-191	93	20	10.5599	10.5599	NUM
admet-191	93	21	/	/	SYM
admet-191	93	22	admet.3.3.191	admet.3.3.191	NUM
admet-191	93	23	291	291	NUM
admet-191	93	24	figure	figure	NOUN
admet-191	93	25	2	2	NUM
admet-191	93	26	.	.	PUNCT
admet-191	93	27	verification	verification	NOUN
admet-191	93	28	of	of	ADP
admet-191	93	29	the	the	DET
admet-191	93	30	prion	prion	NOUN
admet-191	93	31	protein	protein	NOUN
admet-191	93	32	(	(	PUNCT
admet-191	93	33	hprpc	hprpc	NOUN
admet-191	93	34	)	)	PUNCT
admet-191	93	35	presence	presence	NOUN
admet-191	93	36	in	in	ADP
admet-191	93	37	e.	e.	PROPN
admet-191	93	38	coli	coli	PROPN
admet-191	93	39	bl21(de3	bl21(de3	NOUN
admet-191	93	40	)	)	PUNCT
admet-191	93	41	cells	cell	NOUN
admet-191	93	42	transformed	transform	VERB
admet-191	93	43	with	with	ADP
admet-191	93	44	a	a	DET
admet-191	93	45	plasmid	plasmid	NOUN
admet-191	93	46	containing	contain	VERB
admet-191	93	47	hprpc	hprpc	NOUN
admet-191	93	48	gene	gene	NOUN
admet-191	93	49	.	.	PUNCT
admet-191	94	1	red	red	ADJ
admet-191	94	2	ellipse	ellipse	NOUN
admet-191	94	3	indicates	indicate	VERB
admet-191	94	4	occurrence	occurrence	NOUN
admet-191	94	5	of	of	ADP
admet-191	94	6	prion	prion	NOUN
admet-191	94	7	protein	protein	NOUN
admet-191	94	8	(	(	PUNCT
admet-191	94	9	size	size	NOUN
admet-191	94	10	20	20	NUM
admet-191	94	11	-	-	SYM
admet-191	94	12	23	23	NUM
admet-191	94	13	kda	kda	NOUN
admet-191	94	14	)	)	PUNCT
admet-191	94	15	.	.	PUNCT
admet-191	95	1	(	(	PUNCT
admet-191	95	2	a	a	X
admet-191	95	3	)	)	PUNCT
admet-191	95	4	gel	gel	NOUN
admet-191	95	5	stained	stain	VERB
admet-191	95	6	with	with	ADP
admet-191	95	7	coomassie	coomassie	ADJ
admet-191	95	8	brilliant	brilliant	ADJ
admet-191	95	9	blue	blue	ADJ
admet-191	95	10	,	,	PUNCT
admet-191	95	11	standard	standard	NOUN
admet-191	95	12	:	:	PUNCT
admet-191	95	13	precision	precision	NOUN
admet-191	95	14	plus	plus	CCONJ
admet-191	95	15	protein	protein	NOUN
admet-191	95	16	dual	dual	PROPN
admet-191	95	17	xtra	xtra	PROPN
admet-191	95	18	standards	standard	NOUN
admet-191	95	19	(	(	PUNCT
admet-191	95	20	bio	bio	NOUN
admet-191	95	21	-	-	NOUN
admet-191	95	22	rad	rad	NOUN
admet-191	95	23	)	)	PUNCT
admet-191	95	24	;	;	PUNCT
admet-191	95	25	(	(	PUNCT
admet-191	95	26	b	b	X
admet-191	95	27	)	)	PUNCT
admet-191	95	28	western	western	ADJ
admet-191	95	29	blot	blot	NOUN
admet-191	95	30	,	,	PUNCT
admet-191	95	31	standard	standard	NOUN
admet-191	95	32	:	:	PUNCT
admet-191	95	33	precision	precision	NOUN
admet-191	95	34	plus	plus	CCONJ
admet-191	95	35	protein	protein	NOUN
admet-191	95	36	dual	dual	PROPN
admet-191	95	37	xtra	xtra	PROPN
admet-191	95	38	standards	standard	NOUN
admet-191	95	39	(	(	PUNCT
admet-191	95	40	bio	bio	NOUN
admet-191	95	41	-	-	PROPN
admet-191	95	42	rad	rad	ADJ
admet-191	95	43	)	)	PUNCT
admet-191	95	44	mr	mr	ADJ
admet-191	95	45	-	-	PUNCT
admet-191	95	46	molecular	molecular	ADJ
admet-191	95	47	mass	mass	NOUN
admet-191	95	48	standard	standard	NOUN
admet-191	95	49	.	.	PUNCT
admet-191	96	1	for	for	ADP
admet-191	96	2	both	both	PRON
admet-191	96	3	(	(	PUNCT
admet-191	96	4	a	a	PRON
admet-191	96	5	and	and	CCONJ
admet-191	96	6	b	b	NOUN
admet-191	96	7	)	)	PUNCT
admet-191	96	8	,	,	PUNCT
admet-191	96	9	lane	lane	NOUN
admet-191	96	10	1	1	NUM
admet-191	96	11	:	:	PUNCT
admet-191	96	12	hprpc	hprpc	NOUN
admet-191	96	13	supernatant	supernatant	NOUN
admet-191	96	14	,	,	PUNCT
admet-191	96	15	lane	lane	NOUN
admet-191	96	16	2	2	NUM
admet-191	96	17	:	:	PUNCT
admet-191	96	18	hprpc	hprpc	NOUN
admet-191	96	19	pellet	pellet	NOUN
admet-191	96	20	,	,	PUNCT
admet-191	96	21	lane	lane	NOUN
admet-191	96	22	3	3	NUM
admet-191	96	23	:	:	PUNCT
admet-191	96	24	hprpc	hprpc	NOUN
admet-191	96	25	/+iptg	/+iptg	PUNCT
admet-191	96	26	supernatant	supernatant	NOUN
admet-191	96	27	,	,	PUNCT
admet-191	96	28	lane	lane	NOUN
admet-191	96	29	4	4	NUM
admet-191	96	30	:	:	PUNCT
admet-191	96	31	hprpc	hprpc	NOUN
admet-191	96	32	/+iptg	/+iptg	PUNCT
admet-191	96	33	pellet	pellet	NOUN
admet-191	96	34	.	.	PUNCT
admet-191	97	1	in	in	ADP
admet-191	97	2	the	the	DET
admet-191	97	3	same	same	ADJ
admet-191	97	4	way	way	NOUN
admet-191	97	5	,	,	PUNCT
admet-191	97	6	the	the	DET
admet-191	97	7	presence	presence	NOUN
admet-191	97	8	of	of	ADP
admet-191	97	9	mt-3	mt-3	NOUN
admet-191	97	10	protein	protein	NOUN
admet-191	97	11	expression	expression	NOUN
admet-191	97	12	was	be	AUX
admet-191	97	13	verified	verify	VERB
admet-191	97	14	(	(	PUNCT
admet-191	97	15	fig	fig	NOUN
admet-191	97	16	.	.	PUNCT
admet-191	98	1	3a	3a	NUM
admet-191	98	2	)	)	PUNCT
admet-191	98	3	.	.	PUNCT
admet-191	99	1	using	use	VERB
admet-191	99	2	western	western	ADJ
admet-191	99	3	-	-	PUNCT
admet-191	99	4	blot	blot	NOUN
admet-191	99	5	a	a	DET
admet-191	99	6	positive	positive	ADJ
admet-191	99	7	band	band	NOUN
admet-191	99	8	with	with	ADP
admet-191	99	9	a	a	DET
admet-191	99	10	size	size	NOUN
admet-191	99	11	of	of	ADP
admet-191	99	12	about	about	ADV
admet-191	99	13	10	10	NUM
admet-191	99	14	kda	kda	NOUN
admet-191	99	15	in	in	ADP
admet-191	99	16	both	both	DET
admet-191	99	17	cell	cell	NOUN
admet-191	99	18	fractions	fraction	NOUN
admet-191	99	19	(	(	PUNCT
admet-191	99	20	supernatant	supernatant	NOUN
admet-191	99	21	and	and	CCONJ
admet-191	99	22	pellet	pellet	NOUN
admet-191	99	23	)	)	PUNCT
admet-191	99	24	supplemented	supplement	VERB
admet-191	99	25	with	with	ADP
admet-191	99	26	iptg	iptg	NOUN
admet-191	99	27	was	be	AUX
admet-191	99	28	verified	verify	VERB
admet-191	99	29	(	(	PUNCT
admet-191	99	30	fig	fig	NOUN
admet-191	99	31	.	.	PUNCT
admet-191	100	1	3b	3b	NUM
admet-191	100	2	)	)	PUNCT
admet-191	100	3	.	.	PUNCT
admet-191	101	1	the	the	DET
admet-191	101	2	same	same	ADJ
admet-191	101	3	results	result	NOUN
admet-191	101	4	were	be	AUX
admet-191	101	5	achieved	achieve	VERB
admet-191	101	6	also	also	ADV
admet-191	101	7	by	by	ADP
admet-191	101	8	dot	dot	NOUN
admet-191	101	9	-	-	PUNCT
admet-191	101	10	blot	blot	NOUN
admet-191	101	11	method	method	NOUN
admet-191	101	12	(	(	PUNCT
admet-191	101	13	not	not	PART
admet-191	101	14	shown	show	VERB
admet-191	101	15	)	)	PUNCT
admet-191	101	16	.	.	PUNCT
admet-191	102	1	figure	figure	VERB
admet-191	102	2	3	3	NUM
admet-191	102	3	.	.	PUNCT
admet-191	103	1	verification	verification	NOUN
admet-191	103	2	of	of	ADP
admet-191	103	3	the	the	DET
admet-191	103	4	metallothionein	metallothionein	ADJ
admet-191	103	5	(	(	PUNCT
admet-191	103	6	mt-3	mt-3	NOUN
admet-191	103	7	)	)	PUNCT
admet-191	103	8	presence	presence	NOUN
admet-191	103	9	in	in	ADP
admet-191	103	10	e.	e.	PROPN
admet-191	103	11	coli	coli	PROPN
admet-191	103	12	bl21(de3	bl21(de3	NOUN
admet-191	103	13	)	)	PUNCT
admet-191	104	1	cells	cell	NOUN
admet-191	104	2	transformed	transform	VERB
admet-191	104	3	with	with	ADP
admet-191	104	4	a	a	DET
admet-191	104	5	plasmid	plasmid	NOUN
admet-191	104	6	containing	contain	VERB
admet-191	104	7	mt-3	mt-3	NOUN
admet-191	104	8	gene	gene	NOUN
admet-191	104	9	.	.	PUNCT
admet-191	105	1	red	red	ADJ
admet-191	105	2	ellipses	ellipsis	NOUN
admet-191	105	3	indicate	indicate	VERB
admet-191	105	4	occurrence	occurrence	NOUN
admet-191	105	5	of	of	ADP
admet-191	105	6	metallothionein	metallothionein	ADJ
admet-191	105	7	3	3	NUM
admet-191	105	8	protein	protein	NOUN
admet-191	105	9	(	(	PUNCT
admet-191	105	10	size	size	NOUN
admet-191	105	11	7	7	NUM
admet-191	105	12	-	-	SYM
admet-191	105	13	10	10	NUM
admet-191	105	14	kda	kda	NOUN
admet-191	105	15	)	)	PUNCT
admet-191	105	16	.	.	PUNCT
admet-191	106	1	(	(	PUNCT
admet-191	106	2	a	a	X
admet-191	106	3	)	)	PUNCT
admet-191	106	4	gel	gel	NOUN
admet-191	106	5	stained	stain	VERB
admet-191	106	6	with	with	ADP
admet-191	106	7	coomassie	coomassie	ADJ
admet-191	106	8	brilliant	brilliant	ADJ
admet-191	106	9	blue	blue	ADJ
admet-191	106	10	,	,	PUNCT
admet-191	106	11	standard	standard	NOUN
admet-191	106	12	:	:	PUNCT
admet-191	106	13	precision	precision	NOUN
admet-191	106	14	plus	plus	CCONJ
admet-191	106	15	protein	protein	NOUN
admet-191	106	16	dual	dual	PROPN
admet-191	106	17	xtra	xtra	PROPN
admet-191	106	18	standards	standard	NOUN
admet-191	106	19	(	(	PUNCT
admet-191	106	20	bio	bio	NOUN
admet-191	106	21	-	-	NOUN
admet-191	106	22	rad	rad	NOUN
admet-191	106	23	)	)	PUNCT
admet-191	106	24	;	;	PUNCT
admet-191	106	25	(	(	PUNCT
admet-191	106	26	b	b	X
admet-191	106	27	)	)	PUNCT
admet-191	106	28	western	western	ADJ
admet-191	106	29	blot	blot	NOUN
admet-191	106	30	,	,	PUNCT
admet-191	106	31	standard	standard	NOUN
admet-191	106	32	:	:	PUNCT
admet-191	106	33	precision	precision	NOUN
admet-191	106	34	plus	plus	CCONJ
admet-191	106	35	protein	protein	NOUN
admet-191	106	36	dual	dual	PROPN
admet-191	106	37	xtra	xtra	PROPN
admet-191	106	38	standards	standard	NOUN
admet-191	106	39	(	(	PUNCT
admet-191	106	40	bio	bio	NOUN
admet-191	106	41	-	-	NOUN
admet-191	106	42	rad	rad	NOUN
admet-191	106	43	)	)	PUNCT
admet-191	106	44	,	,	PUNCT
admet-191	106	45	mr	mr	PROPN
admet-191	106	46	-	-	PUNCT
admet-191	106	47	molecular	molecular	ADJ
admet-191	106	48	mass	mass	NOUN
admet-191	106	49	standard	standard	NOUN
admet-191	106	50	.	.	PUNCT
admet-191	107	1	for	for	ADP
admet-191	107	2	both	both	PRON
admet-191	107	3	(	(	PUNCT
admet-191	107	4	a	a	PRON
admet-191	107	5	and	and	CCONJ
admet-191	107	6	b	b	NOUN
admet-191	107	7	)	)	PUNCT
admet-191	107	8	,	,	PUNCT
admet-191	107	9	lane	lane	PROPN
admet-191	107	10	1	1	NUM
admet-191	107	11	e.	e.	PROPN
admet-191	107	12	coli	coli	PROPN
admet-191	107	13	bl21(de3	bl21(de3	NOUN
admet-191	107	14	)	)	PUNCT
admet-191	107	15	supernatant	supernatant	NOUN
admet-191	107	16	,	,	PUNCT
admet-191	107	17	lane	lane	NOUN
admet-191	107	18	2	2	NUM
admet-191	107	19	:	:	PUNCT
admet-191	107	20	e.	e.	PROPN
admet-191	107	21	coli	coli	PROPN
admet-191	107	22	bl21(de3	bl21(de3	NOUN
admet-191	107	23	)	)	PUNCT
admet-191	107	24	pellet	pellet	NOUN
admet-191	107	25	,	,	PUNCT
admet-191	107	26	lane	lane	NOUN
admet-191	107	27	3	3	NUM
admet-191	107	28	:	:	SYM
admet-191	107	29	mt-3	mt-3	NOUN
admet-191	107	30	supernatant	supernatant	NOUN
admet-191	107	31	,	,	PUNCT
admet-191	107	32	lane	lane	NOUN
admet-191	107	33	4	4	NUM
admet-191	107	34	:	:	PUNCT
admet-191	107	35	mt-3	mt-3	NOUN
admet-191	107	36	pellet	pellet	NOUN
admet-191	107	37	,	,	PUNCT
admet-191	107	38	lane	lane	NOUN
admet-191	107	39	5	5	NUM
admet-191	107	40	:	:	PUNCT
admet-191	107	41	mt-3/+iptg	mt-3/+iptg	NOUN
admet-191	107	42	supernatant	supernatant	NOUN
admet-191	107	43	,	,	PUNCT
admet-191	107	44	lane	lane	NOUN
admet-191	107	45	6	6	NUM
admet-191	107	46	:	:	PUNCT
admet-191	107	47	mt-3/+iptg	mt-3/+iptg	NOUN
admet-191	107	48	pellet	pellet	NOUN
admet-191	107	49	.	.	PUNCT
admet-191	108	1	ruttkay	ruttkay	VERB
admet-191	108	2	-	-	PUNCT
admet-191	108	3	nedecky	nedecky	PROPN
admet-191	108	4	et	et	PROPN
admet-191	108	5	al	al	PROPN
admet-191	108	6	.	.	PROPN
admet-191	108	7	admet	admet	PROPN
admet-191	108	8	&	&	CCONJ
admet-191	108	9	dmpk	dmpk	PROPN
admet-191	108	10	3(3	3(3	NUM
admet-191	108	11	)	)	PUNCT
admet-191	108	12	(	(	PUNCT
admet-191	108	13	2015	2015	NUM
admet-191	108	14	)	)	PUNCT
admet-191	108	15	287	287	NUM
admet-191	108	16	-	-	SYM
admet-191	108	17	295	295	NUM
admet-191	108	18	292	292	NUM
admet-191	108	19	the	the	DET
admet-191	108	20	effect	effect	NOUN
admet-191	108	21	of	of	ADP
admet-191	108	22	metal	metal	NOUN
admet-191	108	23	ions	ion	NOUN
admet-191	108	24	(	(	PUNCT
admet-191	108	25	cu	cu	PROPN
admet-191	108	26	2	2	NUM
admet-191	108	27	+	+	CCONJ
admet-191	108	28	,	,	PUNCT
admet-191	108	29	zn	zn	PROPN
admet-191	108	30	2	2	NUM
admet-191	108	31	+	+	NUM
admet-191	108	32	and	and	CCONJ
admet-191	108	33	cd	cd	PROPN
admet-191	108	34	2	2	NUM
admet-191	108	35	+	+	CCONJ
admet-191	108	36	)	)	PUNCT
admet-191	108	37	on	on	ADP
admet-191	108	38	growth	growth	NOUN
admet-191	108	39	of	of	ADP
admet-191	108	40	bacterial	bacterial	ADJ
admet-191	108	41	cultures	culture	NOUN
admet-191	108	42	expressing	express	VERB
admet-191	108	43	hprp	hprp	PROPN
admet-191	108	44	c	c	PROPN
admet-191	108	45	or	or	CCONJ
admet-191	108	46	mt-3	mt-3	NOUN
admet-191	108	47	proteins	protein	NOUN
admet-191	108	48	an	an	DET
admet-191	108	49	effect	effect	NOUN
admet-191	108	50	of	of	ADP
admet-191	108	51	copper	copper	NOUN
admet-191	108	52	,	,	PUNCT
admet-191	108	53	zinc	zinc	NOUN
admet-191	108	54	and	and	CCONJ
admet-191	108	55	cadmium	cadmium	NOUN
admet-191	108	56	ions	ion	NOUN
admet-191	108	57	on	on	ADP
admet-191	108	58	growth	growth	NOUN
admet-191	108	59	of	of	ADP
admet-191	108	60	bacterial	bacterial	ADJ
admet-191	108	61	cultures	culture	NOUN
admet-191	108	62	expressing	express	VERB
admet-191	108	63	hprp	hprp	PROPN
admet-191	108	64	c	c	PROPN
admet-191	108	65	or	or	CCONJ
admet-191	108	66	mt-3	mt-3	NOUN
admet-191	108	67	proteins	protein	NOUN
admet-191	108	68	was	be	AUX
admet-191	108	69	investigated	investigate	VERB
admet-191	108	70	by	by	ADP
admet-191	108	71	growth	growth	NOUN
admet-191	108	72	curve	curve	NOUN
admet-191	108	73	method	method	NOUN
admet-191	108	74	.	.	PUNCT
admet-191	109	1	the	the	DET
admet-191	109	2	procedure	procedure	NOUN
admet-191	109	3	for	for	ADP
admet-191	109	4	evaluating	evaluate	VERB
admet-191	109	5	antimicrobial	antimicrobial	ADJ
admet-191	109	6	activity	activity	NOUN
admet-191	109	7	of	of	ADP
admet-191	109	8	three	three	NUM
admet-191	109	9	chosen	choose	VERB
admet-191	109	10	heavy	heavy	ADJ
admet-191	109	11	metals	metal	NOUN
admet-191	109	12	(	(	PUNCT
admet-191	109	13	cu2	cu2	NOUN
admet-191	109	14	+	+	PROPN
admet-191	109	15	,	,	PUNCT
admet-191	109	16	zn2	zn2	PROPN
admet-191	109	17	+	+	NOUN
admet-191	109	18	and	and	CCONJ
admet-191	109	19	cd2	cd2	NOUN
admet-191	109	20	+	+	NOUN
admet-191	109	21	)	)	PUNCT
admet-191	109	22	was	be	AUX
admet-191	109	23	based	base	VERB
admet-191	109	24	on	on	ADP
admet-191	109	25	measuring	measure	VERB
admet-191	109	26	the	the	DET
admet-191	109	27	absorbance	absorbance	NOUN
admet-191	109	28	of	of	ADP
admet-191	109	29	transformed	transform	VERB
admet-191	109	30	bacterial	bacterial	ADJ
admet-191	109	31	cultures	culture	NOUN
admet-191	109	32	of	of	ADP
admet-191	109	33	e.	e.	PROPN
admet-191	109	34	coli	coli	NOUN
admet-191	109	35	expressing	express	VERB
admet-191	109	36	the	the	DET
admet-191	109	37	hprp	hprp	NOUN
admet-191	109	38	c	c	PROPN
admet-191	109	39	and	and	CCONJ
admet-191	109	40	mt-3	mt-3	NOUN
admet-191	109	41	proteins	protein	NOUN
admet-191	109	42	compared	compare	VERB
admet-191	109	43	to	to	PART
admet-191	109	44	control	control	VERB
admet-191	109	45	bacterial	bacterial	ADJ
admet-191	109	46	e.	e.	PROPN
admet-191	109	47	coli	coli	PROPN
admet-191	109	48	bl21(de3	bl21(de3	NOUN
admet-191	109	49	)	)	PUNCT
admet-191	109	50	culture	culture	NOUN
admet-191	109	51	,	,	PUNCT
admet-191	109	52	which	which	PRON
admet-191	109	53	was	be	AUX
admet-191	109	54	also	also	ADV
admet-191	109	55	exposed	expose	VERB
admet-191	109	56	to	to	ADP
admet-191	109	57	the	the	DET
admet-191	109	58	action	action	NOUN
admet-191	109	59	of	of	ADP
admet-191	109	60	mentioned	mention	VERB
admet-191	109	61	heavy	heavy	ADJ
admet-191	109	62	metals	metal	NOUN
admet-191	109	63	.	.	PUNCT
admet-191	110	1	figure	figure	NOUN
admet-191	110	2	4	4	NUM
admet-191	110	3	shows	show	VERB
admet-191	110	4	the	the	DET
admet-191	110	5	effect	effect	NOUN
admet-191	110	6	of	of	ADP
admet-191	110	7	metal	metal	NOUN
admet-191	110	8	ions	ion	NOUN
admet-191	110	9	(	(	PUNCT
admet-191	110	10	cu	cu	PROPN
admet-191	110	11	2	2	NUM
admet-191	110	12	+	+	CCONJ
admet-191	110	13	,	,	PUNCT
admet-191	110	14	zn	zn	PROPN
admet-191	110	15	2	2	NUM
admet-191	110	16	+	+	NUM
admet-191	110	17	and	and	CCONJ
admet-191	110	18	cd	cd	PROPN
admet-191	110	19	2	2	NUM
admet-191	110	20	+	+	CCONJ
admet-191	110	21	)	)	PUNCT
admet-191	110	22	on	on	ADP
admet-191	110	23	the	the	DET
admet-191	110	24	proliferation	proliferation	NOUN
admet-191	110	25	of	of	ADP
admet-191	110	26	transformed	transform	VERB
admet-191	110	27	bacterial	bacterial	ADJ
admet-191	110	28	cultures	culture	NOUN
admet-191	110	29	expressing	express	VERB
admet-191	110	30	hprp	hprp	PROPN
admet-191	110	31	c	c	PROPN
admet-191	110	32	or	or	CCONJ
admet-191	110	33	mt-3	mt-3	NOUN
admet-191	110	34	genes	gene	NOUN
admet-191	110	35	.	.	PUNCT
admet-191	111	1	figure	figure	NOUN
admet-191	111	2	4	4	NUM
admet-191	111	3	.	.	PUNCT
admet-191	111	4	spectrophotometric	spectrophotometric	ADJ
admet-191	111	5	determination	determination	NOUN
admet-191	111	6	of	of	ADP
admet-191	111	7	growth	growth	NOUN
admet-191	111	8	curves	curve	NOUN
admet-191	111	9	obtained	obtain	VERB
admet-191	111	10	after	after	ADP
admet-191	111	11	treatment	treatment	NOUN
admet-191	111	12	of	of	ADP
admet-191	111	13	e.	e.	PROPN
admet-191	111	14	coli	coli	NOUN
admet-191	112	1	bl21	bl21	PROPN
admet-191	112	2	cells	cell	NOUN
admet-191	112	3	transformed	transform	VERB
admet-191	112	4	with	with	ADP
admet-191	112	5	an	an	DET
admet-191	112	6	empty	empty	ADJ
admet-191	112	7	plasmid	plasmid	NOUN
admet-191	112	8	(	(	PUNCT
admet-191	112	9	a	a	X
admet-191	112	10	)	)	PUNCT
admet-191	112	11	,	,	PUNCT
admet-191	113	1	plasmid	plasmid	NOUN
admet-191	113	2	containing	contain	VERB
admet-191	113	3	hprp	hprp	PROPN
admet-191	113	4	c	c	PROPN
admet-191	113	5	gene	gene	NOUN
admet-191	113	6	(	(	PUNCT
admet-191	113	7	b	b	NOUN
admet-191	113	8	)	)	PUNCT
admet-191	113	9	or	or	CCONJ
admet-191	113	10	mt-3	mt-3	NUM
admet-191	113	11	gene	gene	NOUN
admet-191	113	12	(	(	PUNCT
admet-191	113	13	c	c	NOUN
admet-191	113	14	)	)	PUNCT
admet-191	113	15	with	with	ADP
admet-191	113	16	0	0	NUM
admet-191	113	17	,	,	PUNCT
admet-191	113	18	10	10	NUM
admet-191	113	19	,	,	PUNCT
admet-191	113	20	50	50	NUM
admet-191	113	21	,	,	PUNCT
admet-191	113	22	150	150	NUM
admet-191	113	23	and	and	CCONJ
admet-191	113	24	300	300	NUM
admet-191	113	25	μm	μm	NOUN
admet-191	113	26	concentration	concentration	NOUN
admet-191	113	27	of	of	ADP
admet-191	113	28	metal	metal	NOUN
admet-191	113	29	ions	ion	NOUN
admet-191	113	30	cd	cd	NOUN
admet-191	113	31	(	(	PUNCT
admet-191	113	32	a	a	NOUN
admet-191	113	33	)	)	PUNCT
admet-191	113	34	,	,	PUNCT
admet-191	113	35	cu	cu	PROPN
admet-191	113	36	(	(	PUNCT
admet-191	113	37	b	b	NOUN
admet-191	113	38	)	)	PUNCT
admet-191	113	39	and	and	CCONJ
admet-191	113	40	zn	zn	PROPN
admet-191	113	41	(	(	PUNCT
admet-191	113	42	c	c	NOUN
admet-191	113	43	)	)	PUNCT
admet-191	113	44	.	.	PUNCT
admet-191	114	1	average	average	ADJ
admet-191	114	2	values	value	NOUN
admet-191	114	3	ic	ic	X
admet-191	114	4	50	50	NUM
admet-191	114	5	(	(	PUNCT
admet-191	114	6	50	50	NUM
admet-191	114	7	%	%	NOUN
admet-191	114	8	inhibitory	inhibitory	ADJ
admet-191	114	9	concentration	concentration	NOUN
admet-191	114	10	)	)	PUNCT
admet-191	114	11	calculated	calculate	VERB
admet-191	114	12	from	from	ADP
admet-191	114	13	all	all	DET
admet-191	114	14	growth	growth	NOUN
admet-191	114	15	curves	curve	NOUN
admet-191	114	16	are	be	AUX
admet-191	114	17	given	give	VERB
admet-191	114	18	.	.	PUNCT
admet-191	115	1	data	datum	NOUN
admet-191	115	2	represent	represent	AUX
admet-191	115	3	mean	mean	NOUN
admet-191	115	4	calculated	calculate	VERB
admet-191	115	5	from	from	ADP
admet-191	115	6	3	3	NUM
admet-191	115	7	measurements	measurement	NOUN
admet-191	115	8	.	.	PUNCT
admet-191	116	1	cells	cell	NOUN
admet-191	116	2	,	,	PUNCT
admet-191	116	3	which	which	PRON
admet-191	116	4	expressed	express	VERB
admet-191	116	5	mt-3	mt-3	NOUN
admet-191	116	6	protein	protein	NOUN
admet-191	116	7	and	and	CCONJ
admet-191	116	8	were	be	AUX
admet-191	116	9	exposed	expose	VERB
admet-191	116	10	to	to	ADP
admet-191	116	11	the	the	DET
admet-191	116	12	increasing	increase	VERB
admet-191	116	13	concentration	concentration	NOUN
admet-191	116	14	of	of	ADP
admet-191	116	15	cadmium	cadmium	NOUN
admet-191	116	16	ions	ion	NOUN
admet-191	116	17	,	,	PUNCT
admet-191	116	18	exhibited	exhibit	VERB
admet-191	116	19	more	more	ADV
admet-191	116	20	effective	effective	ADJ
admet-191	116	21	protection	protection	NOUN
admet-191	116	22	against	against	ADP
admet-191	116	23	toxic	toxic	ADJ
admet-191	116	24	effects	effect	NOUN
admet-191	116	25	induced	induce	VERB
admet-191	116	26	by	by	ADP
admet-191	116	27	cadmium(ii	cadmium(ii	NOUN
admet-191	116	28	)	)	PUNCT
admet-191	116	29	(	(	PUNCT
admet-191	116	30	ic	ic	PROPN
admet-191	116	31	50	50	NUM
admet-191	116	32	=	=	SYM
admet-191	116	33	90.1	90.1	NUM
admet-191	116	34	μm	μm	NUM
admet-191	116	35	)	)	PUNCT
admet-191	116	36	than	than	ADP
admet-191	116	37	cells	cell	NOUN
admet-191	116	38	expressing	express	VERB
admet-191	116	39	hprpc	hprpc	NOUN
admet-191	116	40	protein	protein	NOUN
admet-191	116	41	(	(	PUNCT
admet-191	116	42	ic	ic	PROPN
admet-191	116	43	50	50	NUM
admet-191	116	44	=	=	NUM
admet-191	116	45	11.2	11.2	NUM
admet-191	116	46	μm	μm	NUM
admet-191	116	47	)	)	PUNCT
admet-191	116	48	(	(	PUNCT
admet-191	116	49	figs	fig	NOUN
admet-191	116	50	.	.	PUNCT
admet-191	117	1	4a	4a	NUM
admet-191	117	2	-	-	PUNCT
admet-191	117	3	a	a	NOUN
admet-191	117	4	,	,	PUNCT
admet-191	117	5	b	b	NOUN
admet-191	117	6	,	,	PUNCT
admet-191	117	7	c	c	NOUN
admet-191	117	8	)	)	PUNCT
admet-191	117	9	.	.	PUNCT
admet-191	118	1	on	on	ADP
admet-191	118	2	the	the	DET
admet-191	118	3	other	other	ADJ
admet-191	118	4	hand	hand	NOUN
admet-191	118	5	,	,	PUNCT
admet-191	118	6	the	the	DET
admet-191	118	7	application	application	NOUN
admet-191	118	8	of	of	ADP
admet-191	118	9	admet	admet	PROPN
admet-191	118	10	&	&	CCONJ
admet-191	118	11	dmpk	dmpk	PROPN
admet-191	118	12	3(3	3(3	NUM
admet-191	118	13	)	)	PUNCT
admet-191	118	14	(	(	PUNCT
admet-191	118	15	2015	2015	NUM
admet-191	118	16	)	)	PUNCT
admet-191	118	17	287	287	NUM
admet-191	118	18	-	-	SYM
admet-191	118	19	295	295	NUM
admet-191	118	20	prion	prion	NOUN
admet-191	118	21	interactions	interaction	NOUN
admet-191	118	22	with	with	ADP
admet-191	118	23	metals	metal	NOUN
admet-191	118	24	and	and	CCONJ
admet-191	118	25	metallothionein	metallothionein	ADJ
admet-191	118	26	doi	doi	PROPN
admet-191	118	27	:	:	PUNCT
admet-191	118	28	10.5599	10.5599	NUM
admet-191	118	29	/	/	SYM
admet-191	118	30	admet.3.3.191	admet.3.3.191	NUM
admet-191	118	31	293	293	NUM
admet-191	118	32	copper(ii	copper(ii	NOUN
admet-191	118	33	)	)	PUNCT
admet-191	118	34	ions	ion	NOUN
admet-191	118	35	caused	cause	VERB
admet-191	118	36	on	on	ADP
admet-191	118	37	the	the	DET
admet-191	118	38	cells	cell	NOUN
admet-191	118	39	expressing	express	VERB
admet-191	118	40	hprp	hprp	PROPN
admet-191	118	41	c	c	NOUN
admet-191	118	42	higher	high	ADJ
admet-191	118	43	inhibition	inhibition	NOUN
admet-191	118	44	of	of	ADP
admet-191	118	45	growth	growth	NOUN
admet-191	118	46	(	(	PUNCT
admet-191	118	47	ic	ic	PROPN
admet-191	118	48	50	50	NUM
admet-191	118	49	=	=	SYM
admet-191	118	50	2.7	2.7	NUM
admet-191	118	51	μm	μm	NUM
admet-191	118	52	)	)	PUNCT
admet-191	118	53	and	and	CCONJ
admet-191	118	54	growth	growth	NOUN
admet-191	118	55	was	be	AUX
admet-191	118	56	decreased	decrease	VERB
admet-191	118	57	by	by	ADP
admet-191	118	58	46	46	NUM
admet-191	118	59	%	%	NOUN
admet-191	118	60	in	in	ADP
admet-191	118	61	presence	presence	NOUN
admet-191	118	62	of	of	ADP
admet-191	118	63	300	300	NUM
admet-191	118	64	µm	µm	ADP
admet-191	118	65	concentration	concentration	NOUN
admet-191	118	66	of	of	ADP
admet-191	118	67	copper	copper	NOUN
admet-191	118	68	(	(	PUNCT
admet-191	118	69	figs	fig	NOUN
admet-191	118	70	.	.	PUNCT
admet-191	119	1	4b	4b	PROPN
admet-191	119	2	-	-	PUNCT
admet-191	119	3	a;b	a;b	NUM
admet-191	119	4	)	)	PUNCT
admet-191	119	5	.	.	PUNCT
admet-191	120	1	the	the	DET
admet-191	120	2	concentration	concentration	NOUN
admet-191	120	3	required	require	VERB
admet-191	120	4	for	for	ADP
admet-191	120	5	growth	growth	NOUN
admet-191	120	6	inhibition	inhibition	NOUN
admet-191	120	7	of	of	ADP
admet-191	120	8	50	50	NUM
admet-191	120	9	%	%	NOUN
admet-191	120	10	of	of	ADP
admet-191	120	11	cells	cell	NOUN
admet-191	120	12	was	be	AUX
admet-191	120	13	measured	measure	VERB
admet-191	120	14	on	on	ADP
admet-191	120	15	5.1	5.1	NUM
admet-191	120	16	µm	µm	NOUN
admet-191	120	17	and	and	CCONJ
admet-191	120	18	the	the	DET
admet-191	120	19	highest	high	ADJ
admet-191	120	20	used	use	VERB
admet-191	120	21	concentration	concentration	NOUN
admet-191	120	22	of	of	ADP
admet-191	120	23	copper	copper	NOUN
admet-191	120	24	(	(	PUNCT
admet-191	120	25	ii	ii	NOUN
admet-191	120	26	)	)	PUNCT
admet-191	120	27	caused	cause	VERB
admet-191	120	28	56	56	NUM
admet-191	120	29	%	%	NOUN
admet-191	120	30	growth	growth	NOUN
admet-191	120	31	inhibition	inhibition	NOUN
admet-191	120	32	of	of	ADP
admet-191	120	33	cells	cell	NOUN
admet-191	120	34	(	(	PUNCT
admet-191	120	35	fig	fig	NOUN
admet-191	120	36	.	.	PUNCT
admet-191	121	1	4b	4b	PROPN
admet-191	121	2	-	-	PUNCT
admet-191	121	3	a	a	NOUN
admet-191	121	4	)	)	PUNCT
admet-191	121	5	.	.	PUNCT
admet-191	122	1	the	the	DET
admet-191	122	2	best	good	ADJ
admet-191	122	3	protection	protection	NOUN
admet-191	122	4	against	against	ADP
admet-191	122	5	copper	copper	NOUN
admet-191	122	6	(	(	PUNCT
admet-191	122	7	ii	ii	NOUN
admet-191	122	8	)	)	PUNCT
admet-191	122	9	toxicity	toxicity	NOUN
admet-191	122	10	showed	show	VERB
admet-191	122	11	cells	cell	NOUN
admet-191	122	12	expressing	express	VERB
admet-191	122	13	mt-3	mt-3	NOUN
admet-191	122	14	(	(	PUNCT
admet-191	122	15	ic	ic	PROPN
admet-191	122	16	50	50	NUM
admet-191	122	17	=	=	SYM
admet-191	122	18	10.0	10.0	NUM
admet-191	122	19	μm	μm	NUM
admet-191	122	20	)	)	PUNCT
admet-191	122	21	with	with	ADP
admet-191	122	22	37	37	NUM
admet-191	122	23	%	%	NOUN
admet-191	122	24	inhibition	inhibition	NOUN
admet-191	122	25	of	of	ADP
admet-191	122	26	bacterial	bacterial	ADJ
admet-191	122	27	growth	growth	NOUN
admet-191	122	28	(	(	PUNCT
admet-191	122	29	fig	fig	NOUN
admet-191	122	30	.	.	PUNCT
admet-191	123	1	4b	4b	PROPN
admet-191	123	2	-	-	PUNCT
admet-191	123	3	c	c	NOUN
admet-191	123	4	)	)	PUNCT
admet-191	123	5	.	.	PUNCT
admet-191	124	1	similar	similar	ADJ
admet-191	124	2	findings	finding	NOUN
admet-191	124	3	as	as	ADP
admet-191	124	4	in	in	ADP
admet-191	124	5	the	the	DET
admet-191	124	6	presence	presence	NOUN
admet-191	124	7	of	of	ADP
admet-191	124	8	cadmium	cadmium	NOUN
admet-191	124	9	(	(	PUNCT
admet-191	124	10	ii	ii	NOUN
admet-191	124	11	)	)	PUNCT
admet-191	124	12	ions	ion	NOUN
admet-191	124	13	were	be	AUX
admet-191	124	14	also	also	ADV
admet-191	124	15	observed	observe	VERB
admet-191	124	16	in	in	ADP
admet-191	124	17	the	the	DET
admet-191	124	18	case	case	NOUN
admet-191	124	19	of	of	ADP
admet-191	124	20	zinc	zinc	NOUN
admet-191	124	21	(	(	PUNCT
admet-191	124	22	ii	ii	NOUN
admet-191	124	23	)	)	PUNCT
admet-191	124	24	ions	ion	NOUN
admet-191	124	25	.	.	PUNCT
admet-191	125	1	the	the	DET
admet-191	125	2	cells	cell	NOUN
admet-191	125	3	expressing	express	VERB
admet-191	125	4	hprp	hprp	PROPN
admet-191	125	5	c	c	PROPN
admet-191	125	6	protein	protein	NOUN
admet-191	125	7	were	be	AUX
admet-191	125	8	exposed	expose	VERB
admet-191	125	9	to	to	ADP
admet-191	125	10	the	the	DET
admet-191	125	11	increasing	increase	VERB
admet-191	125	12	concentration	concentration	NOUN
admet-191	125	13	of	of	ADP
admet-191	125	14	zinc(ii	zinc(ii	NUM
admet-191	125	15	)	)	PUNCT
admet-191	125	16	ions	ion	NOUN
admet-191	125	17	.	.	PUNCT
admet-191	126	1	the	the	DET
admet-191	126	2	best	good	ADJ
admet-191	126	3	protection	protection	NOUN
admet-191	126	4	against	against	ADP
admet-191	126	5	toxicity	toxicity	NOUN
admet-191	126	6	of	of	ADP
admet-191	126	7	metals	metal	NOUN
admet-191	126	8	was	be	AUX
admet-191	126	9	observed	observe	VERB
admet-191	126	10	after	after	ADP
admet-191	126	11	addition	addition	NOUN
admet-191	126	12	of	of	ADP
admet-191	126	13	zinc	zinc	NOUN
admet-191	126	14	(	(	PUNCT
admet-191	126	15	ii	ii	NOUN
admet-191	126	16	)	)	PUNCT
admet-191	126	17	ions	ion	NOUN
admet-191	126	18	(	(	PUNCT
admet-191	126	19	ic	ic	PROPN
admet-191	126	20	50	50	NUM
admet-191	126	21	=	=	NUM
admet-191	126	22	520.8	520.8	NUM
admet-191	126	23	μm	μm	NUM
admet-191	126	24	)	)	PUNCT
admet-191	126	25	,	,	PUNCT
admet-191	126	26	as	as	SCONJ
admet-191	126	27	it	it	PRON
admet-191	126	28	is	be	AUX
admet-191	126	29	shown	show	VERB
admet-191	126	30	in	in	ADP
admet-191	126	31	figs	fig	NOUN
admet-191	126	32	.	.	PUNCT
admet-191	127	1	4c	4c	NOUN
admet-191	127	2	-	-	PUNCT
admet-191	127	3	a	a	NOUN
admet-191	127	4	,	,	PUNCT
admet-191	127	5	b.	b.	NOUN
admet-191	127	6	these	these	DET
admet-191	127	7	bacterial	bacterial	ADJ
admet-191	127	8	cultures	culture	NOUN
admet-191	127	9	were	be	AUX
admet-191	127	10	inhibited	inhibit	VERB
admet-191	127	11	by	by	ADP
admet-191	127	12	treatment	treatment	NOUN
admet-191	127	13	with	with	ADP
admet-191	127	14	zinc	zinc	NOUN
admet-191	127	15	(	(	PUNCT
admet-191	127	16	ii	ii	NOUN
admet-191	127	17	)	)	PUNCT
admet-191	127	18	ions	ion	NOUN
admet-191	127	19	.	.	PUNCT
admet-191	128	1	the	the	DET
admet-191	128	2	cells	cell	NOUN
admet-191	128	3	expressing	express	VERB
admet-191	128	4	mt-3	mt-3	NOUN
admet-191	128	5	(	(	PUNCT
admet-191	128	6	ic	ic	PROPN
admet-191	128	7	50	50	NUM
admet-191	128	8	=	=	SYM
admet-191	128	9	46.9	46.9	NUM
admet-191	128	10	μm	μm	NOUN
admet-191	128	11	,	,	PUNCT
admet-191	128	12	figs	fig	NOUN
admet-191	128	13	.	.	PUNCT
admet-191	129	1	4c	4c	NOUN
admet-191	129	2	-	-	PUNCT
admet-191	129	3	c	c	NOUN
admet-191	129	4	)	)	PUNCT
admet-191	129	5	were	be	AUX
admet-191	129	6	less	less	ADV
admet-191	129	7	protected	protect	VERB
admet-191	129	8	(	(	PUNCT
admet-191	129	9	25	25	NUM
admet-191	129	10	%	%	NOUN
admet-191	129	11	inhibition	inhibition	NOUN
admet-191	129	12	of	of	ADP
admet-191	129	13	bacterial	bacterial	ADJ
admet-191	129	14	growth	growth	NOUN
admet-191	129	15	in	in	ADP
admet-191	129	16	presence	presence	NOUN
admet-191	129	17	of	of	ADP
admet-191	129	18	300	300	NUM
admet-191	129	19	μm	μm	NOUN
admet-191	129	20	concentration	concentration	NOUN
admet-191	129	21	of	of	ADP
admet-191	129	22	zinc	zinc	NOUN
admet-191	129	23	(	(	PUNCT
admet-191	129	24	ii	ii	NOUN
admet-191	129	25	)	)	PUNCT
admet-191	129	26	and	and	CCONJ
admet-191	129	27	the	the	DET
admet-191	129	28	least	least	ADJ
admet-191	129	29	protected	protect	VERB
admet-191	129	30	were	be	AUX
admet-191	129	31	the	the	DET
admet-191	129	32	control	control	NOUN
admet-191	129	33	cells	cell	NOUN
admet-191	129	34	(	(	PUNCT
admet-191	129	35	ic	ic	PROPN
admet-191	129	36	50	50	NUM
admet-191	129	37	=	=	SYM
admet-191	129	38	5.0	5.0	NUM
admet-191	129	39	μm	μm	NOUN
admet-191	129	40	,	,	PUNCT
admet-191	129	41	fig	fig	NOUN
admet-191	129	42	.	.	PUNCT
admet-191	130	1	4c	4c	NOUN
admet-191	130	2	-	-	PUNCT
admet-191	130	3	a	a	NOUN
admet-191	130	4	)	)	PUNCT
admet-191	130	5	.	.	PUNCT
admet-191	131	1	the	the	DET
admet-191	131	2	control	control	NOUN
admet-191	131	3	cells	cell	NOUN
admet-191	131	4	were	be	AUX
admet-191	131	5	inhibited	inhibit	VERB
admet-191	131	6	by	by	ADP
admet-191	131	7	up	up	ADP
admet-191	131	8	of	of	ADP
admet-191	131	9	69	69	NUM
admet-191	131	10	%	%	NOUN
admet-191	131	11	after	after	ADP
admet-191	131	12	addition	addition	NOUN
admet-191	131	13	of	of	ADP
admet-191	131	14	the	the	DET
admet-191	131	15	same	same	ADJ
admet-191	131	16	concentration	concentration	NOUN
admet-191	131	17	of	of	ADP
admet-191	131	18	zinc	zinc	NOUN
admet-191	131	19	(	(	PUNCT
admet-191	131	20	ii	ii	NOUN
admet-191	131	21	)	)	PUNCT
admet-191	131	22	ions	ion	NOUN
admet-191	131	23	.	.	PUNCT
admet-191	132	1	electrochemical	electrochemical	ADJ
admet-191	132	2	determination	determination	NOUN
admet-191	132	3	of	of	ADP
admet-191	132	4	the	the	DET
admet-191	132	5	total	total	ADJ
admet-191	132	6	mt	mt	PROPN
admet-191	132	7	level	level	NOUN
admet-191	132	8	after	after	ADP
admet-191	132	9	addition	addition	NOUN
admet-191	132	10	of	of	ADP
admet-191	132	11	metal	metal	NOUN
admet-191	132	12	ions	ion	NOUN
admet-191	132	13	(	(	PUNCT
admet-191	132	14	cu2	cu2	NOUN
admet-191	132	15	+	+	PROPN
admet-191	132	16	,	,	PUNCT
admet-191	132	17	zn2	zn2	PROPN
admet-191	132	18	+	+	NOUN
admet-191	132	19	and	and	CCONJ
admet-191	132	20	cd2	cd2	NOUN
admet-191	132	21	+	+	NOUN
admet-191	132	22	)	)	PUNCT
admet-191	132	23	to	to	ADP
admet-191	132	24	the	the	DET
admet-191	132	25	bacterial	bacterial	ADJ
admet-191	132	26	cultures	culture	NOUN
admet-191	132	27	expressing	express	VERB
admet-191	132	28	hprpc	hprpc	NOUN
admet-191	132	29	or	or	CCONJ
admet-191	132	30	mt-3	mt-3	NOUN
admet-191	132	31	proteins	protein	NOUN
admet-191	132	32	before	before	ADP
admet-191	132	33	the	the	DET
admet-191	132	34	measurement	measurement	NOUN
admet-191	132	35	of	of	ADP
admet-191	132	36	total	total	ADJ
admet-191	132	37	mt	mt	PROPN
admet-191	132	38	level	level	NOUN
admet-191	132	39	,	,	PUNCT
admet-191	132	40	a	a	DET
admet-191	132	41	calibration	calibration	NOUN
admet-191	132	42	curve	curve	NOUN
admet-191	132	43	(	(	PUNCT
admet-191	132	44	fig	fig	NOUN
admet-191	132	45	.	.	PUNCT
admet-191	133	1	5a	5a	NUM
admet-191	133	2	)	)	PUNCT
admet-191	133	3	was	be	AUX
admet-191	133	4	determined	determine	VERB
admet-191	133	5	by	by	ADP
admet-191	133	6	measuring	measure	VERB
admet-191	133	7	different	different	ADJ
admet-191	133	8	concentrations	concentration	NOUN
admet-191	133	9	of	of	ADP
admet-191	133	10	mt	mt	PROPN
admet-191	133	11	2a	2a	PROPN
admet-191	133	12	standard	standard	NOUN
admet-191	133	13	(	(	PUNCT
admet-191	133	14	0.39	0.39	NUM
admet-191	133	15	–	–	PUNCT
admet-191	133	16	25.0	25.0	NUM
admet-191	133	17	μg	μg	NOUN
admet-191	133	18	/	/	SYM
admet-191	133	19	ml	ml	NOUN
admet-191	133	20	)	)	PUNCT
admet-191	133	21	,	,	PUNCT
admet-191	133	22	whereas	whereas	SCONJ
admet-191	133	23	dp	dp	NOUN
admet-191	133	24	voltammograms	voltammogram	NOUN
admet-191	133	25	are	be	AUX
admet-191	133	26	shown	show	VERB
admet-191	133	27	in	in	ADP
admet-191	133	28	fig	fig	NOUN
admet-191	133	29	.	.	PUNCT
admet-191	134	1	5b	5b	NUM
admet-191	134	2	.	.	PUNCT
admet-191	135	1	catalytic	catalytic	ADJ
admet-191	135	2	signal	signal	PROPN
admet-191	135	3	cat2	cat2	PROPN
admet-191	135	4	measured	measure	VERB
admet-191	135	5	at	at	ADP
admet-191	135	6	the	the	DET
admet-191	135	7	potential	potential	NOUN
admet-191	135	8	of	of	ADP
admet-191	135	9	-1.56	-1.56	NUM
admet-191	135	10	v	v	NOUN
admet-191	135	11	linearly	linearly	ADV
admet-191	135	12	corresponded	correspond	VERB
admet-191	135	13	to	to	ADP
admet-191	135	14	the	the	DET
admet-191	135	15	concentration	concentration	NOUN
admet-191	135	16	of	of	ADP
admet-191	135	17	metallothionein	metallothionein	ADJ
admet-191	135	18	.	.	PUNCT
admet-191	136	1	mt	mt	PROPN
admet-191	136	2	values	value	NOUN
admet-191	136	3	obtained	obtain	VERB
admet-191	136	4	by	by	ADP
admet-191	136	5	reading	read	VERB
admet-191	136	6	from	from	ADP
admet-191	136	7	the	the	DET
admet-191	136	8	calibration	calibration	NOUN
admet-191	136	9	curve	curve	NOUN
admet-191	136	10	were	be	AUX
admet-191	136	11	recalculated	recalculate	VERB
admet-191	136	12	to	to	ADP
admet-191	136	13	mg	mg	PROPN
admet-191	136	14	of	of	ADP
admet-191	136	15	protein	protein	NOUN
admet-191	136	16	determined	determine	VERB
admet-191	136	17	in	in	ADP
admet-191	136	18	the	the	DET
admet-191	136	19	sample	sample	NOUN
admet-191	136	20	.	.	PUNCT
admet-191	137	1	figure	figure	NOUN
admet-191	137	2	5	5	NUM
admet-191	137	3	.	.	PUNCT
admet-191	138	1	(	(	PUNCT
admet-191	138	2	a	a	X
admet-191	138	3	)	)	PUNCT
admet-191	138	4	calibration	calibration	NOUN
admet-191	138	5	curve	curve	NOUN
admet-191	138	6	of	of	ADP
admet-191	138	7	total	total	ADJ
admet-191	138	8	mt	mt	PROPN
admet-191	138	9	determined	determine	VERB
admet-191	138	10	using	use	VERB
admet-191	138	11	dpv	dpv	PROPN
admet-191	138	12	method	method	NOUN
admet-191	138	13	,	,	PUNCT
admet-191	138	14	as	as	SCONJ
admet-191	138	15	electrolyte	electrolyte	ADJ
admet-191	138	16	brdicka	brdicka	NOUN
admet-191	138	17	solution	solution	NOUN
admet-191	138	18	was	be	AUX
admet-191	138	19	used	use	VERB
admet-191	138	20	(	(	PUNCT
admet-191	138	21	1	1	NUM
admet-191	138	22	mm	mm	PROPN
admet-191	138	23	co(nh3)6cl3	co(nh3)6cl3	PROPN
admet-191	138	24	and	and	CCONJ
admet-191	138	25	1	1	NUM
admet-191	138	26	m	m	NOUN
admet-191	138	27	ammonium	ammonium	NOUN
admet-191	138	28	buffer	buffer	NOUN
admet-191	138	29	(	(	PUNCT
admet-191	138	30	nh3(aq	nh3(aq	PROPN
admet-191	138	31	)	)	PUNCT
admet-191	138	32	and	and	CCONJ
admet-191	138	33	nh4cl	nh4cl	NUM
admet-191	138	34	,	,	PUNCT
admet-191	138	35	ph	ph	PROPN
admet-191	138	36	=	=	NOUN
admet-191	138	37	9.6	9.6	NUM
admet-191	138	38	)	)	PUNCT
admet-191	138	39	)	)	PUNCT
admet-191	138	40	.	.	PUNCT
admet-191	139	1	experimental	experimental	ADJ
admet-191	139	2	parameters	parameter	NOUN
admet-191	139	3	were	be	AUX
admet-191	139	4	chosen	choose	VERB
admet-191	139	5	as	as	SCONJ
admet-191	139	6	follows	follow	VERB
admet-191	139	7	:	:	PUNCT
admet-191	139	8	initial	initial	ADJ
admet-191	139	9	potential	potential	ADJ
admet-191	139	10	-0.4	-0.4	NOUN
admet-191	139	11	v	v	NOUN
admet-191	139	12	,	,	PUNCT
admet-191	139	13	end	end	VERB
admet-191	139	14	potential	potential	ADJ
admet-191	139	15	-1.75	-1.75	PROPN
admet-191	139	16	v	v	NOUN
admet-191	139	17	,	,	PUNCT
admet-191	139	18	modulation	modulation	NOUN
admet-191	139	19	time	time	NOUN
admet-191	139	20	0.057	0.057	NUM
admet-191	139	21	s	s	NOUN
admet-191	139	22	,	,	PUNCT
admet-191	139	23	time	time	NOUN
admet-191	139	24	interval	interval	NOUN
admet-191	139	25	0.2	0.2	NUM
admet-191	139	26	s	s	PROPN
admet-191	139	27	,	,	PUNCT
admet-191	139	28	step	step	VERB
admet-191	139	29	potential	potential	ADJ
admet-191	139	30	2	2	NUM
admet-191	139	31	mv	mv	NOUN
admet-191	139	32	,	,	PUNCT
admet-191	139	33	and	and	CCONJ
admet-191	139	34	modulation	modulation	NOUN
admet-191	139	35	amplitude	amplitude	NOUN
admet-191	139	36	250	250	NUM
admet-191	139	37	mv	mv	NOUN
admet-191	139	38	.	.	PUNCT
admet-191	140	1	(	(	PUNCT
admet-191	140	2	b	b	X
admet-191	140	3	)	)	PUNCT
admet-191	140	4	dp	dp	NOUN
admet-191	140	5	voltammograms	voltammogram	NOUN
admet-191	140	6	of	of	ADP
admet-191	140	7	mt	mt	PROPN
admet-191	140	8	standards	standard	NOUN
admet-191	140	9	(	(	PUNCT
admet-191	140	10	0.39	0.39	NUM
admet-191	140	11	25	25	NUM
admet-191	140	12	µg	µg	NOUN
admet-191	140	13	/	/	SYM
admet-191	140	14	ml	ml	NOUN
admet-191	140	15	)	)	PUNCT
admet-191	140	16	obtained	obtain	VERB
admet-191	140	17	from	from	ADP
admet-191	140	18	the	the	DET
admet-191	140	19	calibration	calibration	NOUN
admet-191	140	20	curve	curve	NOUN
admet-191	140	21	.	.	PUNCT
admet-191	141	1	ruttkay	ruttkay	VERB
admet-191	141	2	-	-	PUNCT
admet-191	141	3	nedecky	nedecky	PROPN
admet-191	141	4	et	et	PROPN
admet-191	141	5	al	al	PROPN
admet-191	141	6	.	.	PROPN
admet-191	141	7	admet	admet	PROPN
admet-191	141	8	&	&	CCONJ
admet-191	141	9	dmpk	dmpk	PROPN
admet-191	141	10	3(3	3(3	NUM
admet-191	141	11	)	)	PUNCT
admet-191	141	12	(	(	PUNCT
admet-191	141	13	2015	2015	NUM
admet-191	141	14	)	)	PUNCT
admet-191	141	15	287	287	NUM
admet-191	141	16	-	-	SYM
admet-191	141	17	295	295	NUM
admet-191	141	18	294	294	NUM
admet-191	141	19	further	far	ADV
admet-191	141	20	,	,	PUNCT
admet-191	141	21	dpv	dpv	PROPN
admet-191	141	22	measurements	measurement	NOUN
admet-191	141	23	of	of	ADP
admet-191	141	24	the	the	DET
admet-191	141	25	total	total	ADJ
admet-191	141	26	mt	mt	PROPN
admet-191	141	27	level	level	NOUN
admet-191	141	28	in	in	ADP
admet-191	141	29	the	the	DET
admet-191	141	30	control	control	NOUN
admet-191	141	31	e.	e.	PROPN
admet-191	141	32	coli	coli	NOUN
admet-191	141	33	cells	cell	NOUN
admet-191	141	34	and	and	CCONJ
admet-191	141	35	in	in	ADP
admet-191	141	36	e.	e.	PROPN
admet-191	141	37	coli	coli	NOUN
admet-191	141	38	cells	cell	NOUN
admet-191	141	39	expressing	express	VERB
admet-191	141	40	hprp	hprp	PROPN
admet-191	141	41	c	c	PROPN
admet-191	141	42	or	or	CCONJ
admet-191	141	43	mt-3	mt-3	NOUN
admet-191	141	44	proteins	protein	NOUN
admet-191	141	45	were	be	AUX
admet-191	141	46	performed	perform	VERB
admet-191	141	47	.	.	PUNCT
admet-191	142	1	these	these	DET
admet-191	142	2	cultures	culture	NOUN
admet-191	142	3	were	be	AUX
admet-191	142	4	exposed	expose	VERB
admet-191	142	5	to	to	ADP
admet-191	142	6	the	the	DET
admet-191	142	7	increasing	increase	VERB
admet-191	142	8	concentration	concentration	NOUN
admet-191	142	9	of	of	ADP
admet-191	142	10	two	two	NUM
admet-191	142	11	essential	essential	ADJ
admet-191	142	12	metal	metal	NOUN
admet-191	142	13	ions	ion	NOUN
admet-191	142	14	(	(	PUNCT
admet-191	142	15	cu2	cu2	NOUN
admet-191	142	16	+	+	NUM
admet-191	142	17	and	and	CCONJ
admet-191	142	18	zn2	zn2	PRON
admet-191	142	19	+	+	PROPN
admet-191	142	20	)	)	PUNCT
admet-191	142	21	and	and	CCONJ
admet-191	142	22	one	one	NUM
admet-191	142	23	toxic	toxic	ADJ
admet-191	142	24	metal	metal	NOUN
admet-191	142	25	ion	ion	NOUN
admet-191	142	26	(	(	PUNCT
admet-191	142	27	cd2	cd2	PROPN
admet-191	142	28	+	+	NOUN
admet-191	142	29	)	)	PUNCT
admet-191	142	30	.	.	PUNCT
admet-191	143	1	bacteria	bacteria	NOUN
admet-191	143	2	that	that	PRON
admet-191	143	3	expressed	express	VERB
admet-191	143	4	mt-3	mt-3	NUM
admet-191	143	5	protein	protein	NOUN
admet-191	143	6	,	,	PUNCT
admet-191	143	7	had	have	VERB
admet-191	143	8	slightly	slightly	ADV
admet-191	143	9	higher	high	ADJ
admet-191	143	10	mt	mt	PROPN
admet-191	143	11	levels	level	NOUN
admet-191	143	12	after	after	ADP
admet-191	143	13	application	application	NOUN
admet-191	143	14	of	of	ADP
admet-191	143	15	increasing	increase	VERB
admet-191	143	16	metal	metal	NOUN
admet-191	143	17	concentrations	concentration	NOUN
admet-191	143	18	(	(	PUNCT
admet-191	143	19	25	25	NUM
admet-191	143	20	,	,	PUNCT
admet-191	143	21	50	50	NUM
admet-191	143	22	,	,	PUNCT
admet-191	143	23	75	75	NUM
admet-191	143	24	and	and	CCONJ
admet-191	143	25	150	150	NUM
admet-191	143	26	µm	µm	NOUN
admet-191	143	27	)	)	PUNCT
admet-191	143	28	in	in	ADP
admet-191	143	29	comparison	comparison	NOUN
admet-191	143	30	with	with	ADP
admet-191	143	31	control	control	NOUN
admet-191	143	32	cells	cell	NOUN
admet-191	143	33	with	with	ADP
admet-191	143	34	similar	similar	ADJ
admet-191	143	35	pattern	pattern	NOUN
admet-191	143	36	(	(	PUNCT
admet-191	143	37	fig	fig	NOUN
admet-191	143	38	.	.	PUNCT
admet-191	144	1	6	6	NUM
admet-191	144	2	)	)	PUNCT
admet-191	144	3	.	.	PUNCT
admet-191	145	1	mt	mt	PROPN
admet-191	145	2	expression	expression	NOUN
admet-191	145	3	increased	increase	VERB
admet-191	145	4	at	at	ADP
admet-191	145	5	lowest	low	ADJ
admet-191	145	6	metal	metal	NOUN
admet-191	145	7	concentration	concentration	NOUN
admet-191	145	8	(	(	PUNCT
admet-191	145	9	25	25	NUM
admet-191	145	10	µm	µm	NOUN
admet-191	145	11	)	)	PUNCT
admet-191	145	12	,	,	PUNCT
admet-191	145	13	followed	follow	VERB
admet-191	145	14	by	by	ADP
admet-191	145	15	a	a	DET
admet-191	145	16	decrease	decrease	NOUN
admet-191	145	17	at	at	ADP
admet-191	145	18	higher	high	ADJ
admet-191	145	19	metal	metal	NOUN
admet-191	145	20	concentrations	concentration	NOUN
admet-191	145	21	(	(	PUNCT
admet-191	145	22	50	50	NUM
admet-191	145	23	,	,	PUNCT
admet-191	145	24	75	75	NUM
admet-191	145	25	,	,	PUNCT
admet-191	145	26	and	and	CCONJ
admet-191	145	27	150	150	NUM
admet-191	145	28	µm	µm	NOUN
admet-191	145	29	)	)	PUNCT
admet-191	145	30	.	.	PUNCT
admet-191	146	1	the	the	DET
admet-191	146	2	highest	high	ADJ
admet-191	146	3	increase	increase	NOUN
admet-191	146	4	in	in	ADP
admet-191	146	5	mt	mt	PROPN
admet-191	146	6	levels	level	NOUN
admet-191	146	7	in	in	ADP
admet-191	146	8	bacterial	bacterial	ADJ
admet-191	146	9	cells	cell	NOUN
admet-191	146	10	after	after	ADP
admet-191	146	11	application	application	NOUN
admet-191	146	12	of	of	ADP
admet-191	146	13	cd	cd	PROPN
admet-191	146	14	2	2	NUM
admet-191	146	15	+	+	CCONJ
admet-191	146	16	were	be	AUX
admet-191	146	17	observed	observe	VERB
admet-191	146	18	followed	follow	VERB
admet-191	146	19	by	by	ADP
admet-191	146	20	cells	cell	NOUN
admet-191	146	21	with	with	ADP
admet-191	146	22	addition	addition	NOUN
admet-191	146	23	of	of	ADP
admet-191	146	24	zn	zn	PROPN
admet-191	146	25	2	2	NUM
admet-191	146	26	+	+	NUM
admet-191	146	27	.	.	PUNCT
admet-191	147	1	the	the	DET
admet-191	147	2	smallest	small	ADJ
admet-191	147	3	increases	increase	NOUN
admet-191	147	4	in	in	ADP
admet-191	147	5	mt	mt	PROPN
admet-191	147	6	levels	level	NOUN
admet-191	147	7	were	be	AUX
admet-191	147	8	observed	observe	VERB
admet-191	147	9	in	in	ADP
admet-191	147	10	cells	cell	NOUN
admet-191	147	11	with	with	ADP
admet-191	147	12	addition	addition	NOUN
admet-191	147	13	of	of	ADP
admet-191	147	14	cu	cu	PROPN
admet-191	147	15	2	2	NUM
admet-191	147	16	+	+	NUM
admet-191	147	17	.	.	PUNCT
admet-191	148	1	mt	mt	PROPN
admet-191	148	2	expression	expression	NOUN
admet-191	148	3	pattern	pattern	NOUN
admet-191	148	4	in	in	ADP
admet-191	148	5	hprpc	hprpc	NOUN
admet-191	148	6	transformed	transform	VERB
admet-191	148	7	cells	cell	NOUN
admet-191	148	8	was	be	AUX
admet-191	148	9	different	different	ADJ
admet-191	148	10	.	.	PUNCT
admet-191	149	1	after	after	ADP
admet-191	149	2	application	application	NOUN
admet-191	149	3	of	of	ADP
admet-191	149	4	cu2	cu2	NOUN
admet-191	149	5	+	+	CCONJ
admet-191	149	6	an	an	DET
admet-191	149	7	increase	increase	NOUN
admet-191	149	8	in	in	ADP
admet-191	149	9	mt	mt	PROPN
admet-191	149	10	expression	expression	NOUN
admet-191	149	11	continued	continue	VERB
admet-191	149	12	also	also	ADV
admet-191	149	13	at	at	ADP
admet-191	149	14	higher	high	ADJ
admet-191	149	15	metal	metal	NOUN
admet-191	149	16	concentrations	concentration	NOUN
admet-191	149	17	;	;	PUNCT
admet-191	149	18	and	and	CCONJ
admet-191	149	19	after	after	ADP
admet-191	149	20	application	application	NOUN
admet-191	149	21	of	of	ADP
admet-191	149	22	cd2	cd2	PROPN
admet-191	149	23	+	+	PROPN
admet-191	149	24	and	and	CCONJ
admet-191	149	25	zn2	zn2	PRON
admet-191	149	26	+	+	CCONJ
admet-191	149	27	no	no	DET
admet-191	149	28	decrease	decrease	NOUN
admet-191	149	29	in	in	ADP
admet-191	149	30	mt	mt	PROPN
admet-191	149	31	expression	expression	NOUN
admet-191	149	32	at	at	ADP
admet-191	149	33	higher	high	ADJ
admet-191	149	34	metal	metal	NOUN
admet-191	149	35	concentrations	concentration	NOUN
admet-191	149	36	was	be	AUX
admet-191	149	37	observed	observe	VERB
admet-191	149	38	.	.	PUNCT
admet-191	150	1	figure	figure	VERB
admet-191	150	2	6	6	NUM
admet-191	150	3	.	.	PUNCT
admet-191	151	1	metallothionein	metallothionein	ADJ
admet-191	151	2	content	content	NOUN
admet-191	151	3	in	in	ADP
admet-191	151	4	e.	e.	PROPN
admet-191	151	5	coli	coli	NOUN
admet-191	151	6	cells	cell	NOUN
admet-191	151	7	bl21	bl21	PROPN
admet-191	151	8	transformed	transform	VERB
admet-191	151	9	with	with	ADP
admet-191	151	10	an	an	DET
admet-191	151	11	empty	empty	ADJ
admet-191	151	12	plasmid	plasmid	NOUN
admet-191	151	13	,	,	PUNCT
admet-191	151	14	the	the	DET
admet-191	151	15	plasmid	plasmid	NOUN
admet-191	151	16	containing	contain	VERB
admet-191	151	17	hprp	hprp	PROPN
admet-191	151	18	c	c	PROPN
admet-191	151	19	or	or	CCONJ
admet-191	151	20	mt-3	mt-3	NOUN
admet-191	151	21	gene	gene	NOUN
admet-191	151	22	after	after	ADP
admet-191	151	23	incubation	incubation	NOUN
admet-191	151	24	with	with	ADP
admet-191	151	25	different	different	ADJ
admet-191	151	26	concentrations	concentration	NOUN
admet-191	151	27	of	of	ADP
admet-191	151	28	(	(	PUNCT
admet-191	151	29	a	a	X
admet-191	151	30	)	)	PUNCT
admet-191	151	31	cu	cu	PROPN
admet-191	151	32	,	,	PUNCT
admet-191	151	33	(	(	PUNCT
admet-191	151	34	b	b	X
admet-191	151	35	)	)	PUNCT
admet-191	151	36	zn	zn	PROPN
admet-191	151	37	and	and	CCONJ
admet-191	151	38	(	(	PUNCT
admet-191	151	39	c	c	X
admet-191	151	40	)	)	PUNCT
admet-191	151	41	cd	cd	PROPN
admet-191	151	42	in	in	ADP
admet-191	151	43	concentrations	concentration	NOUN
admet-191	151	44	of	of	ADP
admet-191	151	45	25	25	NUM
admet-191	151	46	,	,	PUNCT
admet-191	151	47	50	50	NUM
admet-191	151	48	,	,	PUNCT
admet-191	151	49	75	75	NUM
admet-191	151	50	,	,	PUNCT
admet-191	151	51	and	and	CCONJ
admet-191	151	52	150	150	NUM
admet-191	151	53	μm	μm	NOUN
admet-191	151	54	compared	compare	VERB
admet-191	151	55	to	to	ADP
admet-191	151	56	control	control	VERB
admet-191	151	57	cells	cell	NOUN
admet-191	151	58	without	without	ADP
admet-191	151	59	addition	addition	NOUN
admet-191	151	60	of	of	ADP
admet-191	151	61	metal	metal	NOUN
admet-191	151	62	.	.	PUNCT
admet-191	152	1	data	datum	NOUN
admet-191	152	2	represent	represent	VERB
admet-191	152	3	mean	mean	PROPN
admet-191	152	4	±	±	PROPN
admet-191	152	5	s.d	s.d	PROPN
admet-191	152	6	.	.	PROPN
admet-191	152	7	calculated	calculate	VERB
admet-191	152	8	from	from	ADP
admet-191	152	9	3	3	NUM
admet-191	152	10	measurements	measurement	NOUN
admet-191	152	11	,	,	PUNCT
admet-191	152	12	ns	ns	ADJ
admet-191	152	13	,	,	PUNCT
admet-191	152	14	not	not	PART
admet-191	152	15	significant	significant	ADJ
admet-191	152	16	,	,	PUNCT
admet-191	152	17	*	*	PUNCT
admet-191	152	18	p	p	X
admet-191	152	19	<	<	X
admet-191	152	20	0.05	0.05	NUM
admet-191	152	21	.	.	PUNCT
admet-191	153	1	conclusions	conclusion	NOUN
admet-191	153	2	clarifying	clarify	VERB
admet-191	153	3	the	the	DET
admet-191	153	4	precise	precise	ADJ
admet-191	153	5	function	function	NOUN
admet-191	153	6	of	of	ADP
admet-191	153	7	mt-3	mt-3	NOUN
admet-191	153	8	and	and	CCONJ
admet-191	153	9	the	the	DET
admet-191	153	10	conversion	conversion	NOUN
admet-191	153	11	of	of	ADP
admet-191	153	12	the	the	DET
admet-191	153	13	prion	prion	NOUN
admet-191	153	14	protein	protein	NOUN
admet-191	153	15	into	into	ADP
admet-191	153	16	its	its	PRON
admet-191	153	17	pathological	pathological	ADJ
admet-191	153	18	form	form	NOUN
admet-191	153	19	would	would	AUX
admet-191	153	20	contribute	contribute	VERB
admet-191	153	21	to	to	ADP
admet-191	153	22	a	a	DET
admet-191	153	23	better	well	ADJ
admet-191	153	24	understanding	understanding	NOUN
admet-191	153	25	of	of	ADP
admet-191	153	26	the	the	DET
admet-191	153	27	emergence	emergence	NOUN
admet-191	153	28	of	of	ADP
admet-191	153	29	transmissible	transmissible	ADJ
admet-191	153	30	spongiform	spongiform	NOUN
admet-191	153	31	encephalopathies	encephalopathy	NOUN
admet-191	153	32	and	and	CCONJ
admet-191	153	33	the	the	DET
admet-191	153	34	development	development	NOUN
admet-191	153	35	of	of	ADP
admet-191	153	36	effective	effective	ADJ
admet-191	153	37	drugs	drug	NOUN
admet-191	153	38	to	to	PART
admet-191	153	39	cure	cure	VERB
admet-191	153	40	them	they	PRON
admet-191	153	41	.	.	PUNCT
admet-191	154	1	the	the	DET
admet-191	154	2	first	first	ADJ
admet-191	154	3	step	step	NOUN
admet-191	154	4	for	for	ADP
admet-191	154	5	research	research	NOUN
admet-191	154	6	of	of	ADP
admet-191	154	7	brain	brain	NOUN
admet-191	154	8	protein	protein	NOUN
admet-191	154	9	functions	function	NOUN
admet-191	154	10	is	be	AUX
admet-191	154	11	the	the	DET
admet-191	154	12	use	use	NOUN
admet-191	154	13	of	of	ADP
admet-191	154	14	a	a	DET
admet-191	154	15	bacterial	bacterial	ADJ
admet-191	154	16	model	model	NOUN
admet-191	154	17	,	,	PUNCT
admet-191	154	18	where	where	SCONJ
admet-191	154	19	it	it	PRON
admet-191	154	20	is	be	AUX
admet-191	154	21	possible	possible	ADJ
admet-191	154	22	to	to	PART
admet-191	154	23	observe	observe	VERB
admet-191	154	24	the	the	DET
admet-191	154	25	effect	effect	NOUN
admet-191	154	26	of	of	ADP
admet-191	154	27	metals	metal	NOUN
admet-191	154	28	on	on	ADP
admet-191	154	29	growth	growth	NOUN
admet-191	154	30	of	of	ADP
admet-191	154	31	bacterial	bacterial	ADJ
admet-191	154	32	cells	cell	NOUN
admet-191	154	33	,	,	PUNCT
admet-191	154	34	in	in	ADP
admet-191	154	35	which	which	PRON
admet-191	154	36	the	the	DET
admet-191	154	37	brain	brain	NOUN
admet-191	154	38	proteins	protein	NOUN
admet-191	154	39	are	be	AUX
admet-191	154	40	produced	produce	VERB
admet-191	154	41	.	.	PUNCT
admet-191	155	1	another	another	DET
admet-191	155	2	interesting	interesting	ADJ
admet-191	155	3	topic	topic	NOUN
admet-191	155	4	is	be	AUX
admet-191	155	5	the	the	DET
admet-191	155	6	monitoring	monitoring	NOUN
admet-191	155	7	of	of	ADP
admet-191	155	8	interconnection	interconnection	NOUN
admet-191	155	9	between	between	ADP
admet-191	155	10	functions	function	NOUN
admet-191	155	11	of	of	ADP
admet-191	155	12	prion	prion	NOUN
admet-191	155	13	protein	protein	NOUN
admet-191	155	14	and	and	CCONJ
admet-191	155	15	mt-3	mt-3	NOUN
admet-191	155	16	.	.	PUNCT
admet-191	156	1	in	in	ADP
admet-191	156	2	this	this	DET
admet-191	156	3	work	work	NOUN
admet-191	156	4	the	the	DET
admet-191	156	5	presence	presence	NOUN
admet-191	156	6	of	of	ADP
admet-191	156	7	both	both	PRON
admet-191	156	8	hprpc	hprpc	NOUN
admet-191	156	9	and	and	CCONJ
admet-191	156	10	mt-3	mt-3	NOUN
admet-191	156	11	protein	protein	NOUN
admet-191	156	12	expression	expression	NOUN
admet-191	156	13	in	in	ADP
admet-191	156	14	bacterial	bacterial	ADJ
admet-191	156	15	cells	cell	NOUN
admet-191	156	16	was	be	AUX
admet-191	156	17	verified	verify	VERB
admet-191	156	18	using	use	VERB
admet-191	156	19	western	western	ADJ
admet-191	156	20	-	-	PUNCT
admet-191	156	21	blot	blot	NOUN
admet-191	156	22	and	and	CCONJ
admet-191	156	23	dot	dot	NOUN
admet-191	156	24	-	-	PUNCT
admet-191	156	25	blot	blot	NOUN
admet-191	156	26	.	.	PUNCT
admet-191	157	1	furthermore	furthermore	ADV
admet-191	157	2	,	,	PUNCT
admet-191	157	3	by	by	ADP
admet-191	157	4	the	the	DET
admet-191	157	5	growth	growth	NOUN
admet-191	157	6	curve	curve	NOUN
admet-191	157	7	measurement	measurement	NOUN
admet-191	157	8	and	and	CCONJ
admet-191	157	9	electrochemical	electrochemical	ADJ
admet-191	157	10	admet	admet	PROPN
admet-191	157	11	&	&	CCONJ
admet-191	157	12	dmpk	dmpk	PROPN
admet-191	157	13	3(3	3(3	NUM
admet-191	157	14	)	)	PUNCT
admet-191	157	15	(	(	PUNCT
admet-191	157	16	2015	2015	NUM
admet-191	157	17	)	)	PUNCT
admet-191	157	18	287	287	NUM
admet-191	157	19	-	-	SYM
admet-191	157	20	295	295	NUM
admet-191	157	21	prion	prion	NOUN
admet-191	157	22	interactions	interaction	NOUN
admet-191	157	23	with	with	ADP
admet-191	157	24	metals	metal	NOUN
admet-191	157	25	and	and	CCONJ
admet-191	157	26	metallothionein	metallothionein	ADJ
admet-191	157	27	doi	doi	PROPN
admet-191	157	28	:	:	PUNCT
admet-191	157	29	10.5599	10.5599	NUM
admet-191	157	30	/	/	SYM
admet-191	157	31	admet.3.3.191	admet.3.3.191	VERB
admet-191	157	32	295	295	NUM
admet-191	157	33	determination	determination	NOUN
admet-191	157	34	of	of	ADP
admet-191	157	35	mt	mt	PROPN
admet-191	157	36	protein	protein	NOUN
admet-191	157	37	levels	level	NOUN
admet-191	157	38	,	,	PUNCT
admet-191	157	39	it	it	PRON
admet-191	157	40	was	be	AUX
admet-191	157	41	found	find	VERB
admet-191	157	42	that	that	SCONJ
admet-191	157	43	after	after	ADP
admet-191	157	44	addition	addition	NOUN
admet-191	157	45	of	of	ADP
admet-191	157	46	zn	zn	PROPN
admet-191	157	47	2	2	NUM
admet-191	157	48	+	+	CCONJ
admet-191	157	49	and	and	CCONJ
admet-191	157	50	cd	cd	PROPN
admet-191	157	51	2	2	NUM
admet-191	157	52	+	+	NUM
admet-191	157	53	mt-3	mt-3	NOUN
admet-191	157	54	protein	protein	NOUN
admet-191	157	55	was	be	AUX
admet-191	157	56	more	more	ADV
admet-191	157	57	effective	effective	ADJ
admet-191	157	58	in	in	ADP
admet-191	157	59	protection	protection	NOUN
admet-191	157	60	of	of	ADP
admet-191	157	61	bacterial	bacterial	ADJ
admet-191	157	62	cells	cell	NOUN
admet-191	157	63	against	against	ADP
admet-191	157	64	toxicity	toxicity	NOUN
admet-191	157	65	of	of	ADP
admet-191	157	66	metals	metal	NOUN
admet-191	157	67	(	(	PUNCT
admet-191	157	68	zn	zn	NOUN
admet-191	157	69	2	2	NUM
admet-191	157	70	+	+	NUM
admet-191	157	71	and	and	CCONJ
admet-191	157	72	cd	cd	PROPN
admet-191	157	73	2	2	NUM
admet-191	157	74	+	+	CCONJ
admet-191	157	75	)	)	PUNCT
admet-191	157	76	than	than	ADP
admet-191	157	77	hprp	hprp	PROPN
admet-191	157	78	c	c	PROPN
admet-191	157	79	.	.	PUNCT
admet-191	158	1	the	the	DET
admet-191	158	2	different	different	ADJ
admet-191	158	3	situation	situation	NOUN
admet-191	158	4	occurred	occur	VERB
admet-191	158	5	in	in	ADP
admet-191	158	6	the	the	DET
admet-191	158	7	case	case	NOUN
admet-191	158	8	of	of	ADP
admet-191	158	9	addition	addition	NOUN
admet-191	158	10	of	of	ADP
admet-191	158	11	cu2	cu2	NOUN
admet-191	158	12	+	+	PROPN
admet-191	158	13	,	,	PUNCT
admet-191	158	14	when	when	SCONJ
admet-191	158	15	the	the	DET
admet-191	158	16	mt-3	mt-3	NOUN
admet-191	158	17	was	be	AUX
admet-191	158	18	equally	equally	ADV
admet-191	158	19	effective	effective	ADJ
admet-191	158	20	as	as	ADP
admet-191	158	21	hprpc	hprpc	NOUN
admet-191	158	22	,	,	PUNCT
admet-191	158	23	whose	whose	DET
admet-191	158	24	expression	expression	NOUN
admet-191	158	25	even	even	ADV
admet-191	158	26	increased	increase	VERB
admet-191	158	27	the	the	DET
admet-191	158	28	inhibitory	inhibitory	ADJ
admet-191	158	29	effect	effect	NOUN
admet-191	158	30	of	of	ADP
admet-191	158	31	copper	copper	NOUN
admet-191	158	32	ions	ion	NOUN
admet-191	158	33	on	on	ADP
admet-191	158	34	the	the	DET
admet-191	158	35	growth	growth	NOUN
admet-191	158	36	of	of	ADP
admet-191	158	37	bacterial	bacterial	ADJ
admet-191	158	38	cells	cell	NOUN
admet-191	158	39	.	.	PUNCT
admet-191	159	1	acknowledgements	acknowledgement	NOUN
admet-191	159	2	:	:	PUNCT
admet-191	159	3	financial	financial	ADJ
admet-191	159	4	support	support	NOUN
admet-191	159	5	by	by	ADP
admet-191	159	6	ceitec	ceitec	ADJ
admet-191	159	7	cz.1.05/1.1.00/02.0068	cz.1.05/1.1.00/02.0068	PROPN
admet-191	159	8	is	be	AUX
admet-191	159	9	highly	highly	ADV
admet-191	159	10	acknowledged	acknowledge	VERB
admet-191	159	11	.	.	PUNCT
admet-191	160	1	the	the	DET
admet-191	160	2	authors	author	NOUN
admet-191	160	3	express	express	VERB
admet-191	160	4	their	their	PRON
admet-191	160	5	thanks	thank	NOUN
admet-191	160	6	to	to	ADP
admet-191	160	7	vladimir	vladimir	PROPN
admet-191	160	8	pekarik	pekarik	PROPN
admet-191	160	9	for	for	ADP
admet-191	160	10	the	the	DET
admet-191	160	11	preparation	preparation	NOUN
admet-191	160	12	of	of	ADP
admet-191	160	13	plasmids	plasmid	NOUN
admet-191	160	14	and	and	CCONJ
admet-191	160	15	to	to	PART
admet-191	160	16	yazan	yazan	PROPN
admet-191	160	17	haddad	haddad	PROPN
admet-191	160	18	for	for	ADP
admet-191	160	19	a	a	DET
admet-191	160	20	correction	correction	NOUN
admet-191	160	21	of	of	ADP
admet-191	160	22	the	the	DET
admet-191	160	23	english	english	ADJ
admet-191	160	24	language	language	NOUN
admet-191	160	25	style	style	NOUN
admet-191	160	26	.	.	PUNCT
admet-191	161	1	references	reference	NOUN
admet-191	161	2	[	[	X
admet-191	161	3	1	1	X
admet-191	161	4	]	]	PUNCT
admet-191	161	5	s.	s.	PROPN
admet-191	161	6	ortega	ortega	PROPN
admet-191	161	7	-	-	PUNCT
admet-191	161	8	cubero	cubero	PROPN
admet-191	161	9	,	,	PUNCT
admet-191	161	10	m.r	m.r	PROPN
admet-191	161	11	.	.	PROPN
admet-191	161	12	luquin	luquin	PROPN
admet-191	161	13	,	,	PUNCT
admet-191	161	14	i.	i.	PROPN
admet-191	161	15	dominguez	dominguez	PROPN
admet-191	161	16	,	,	PUNCT
admet-191	161	17	j.	j.	PROPN
admet-191	161	18	arbizu	arbizu	PROPN
admet-191	161	19	,	,	PUNCT
admet-191	161	20	i.	i.	PROPN
admet-191	161	21	pagola	pagola	PROPN
admet-191	161	22	,	,	PUNCT
admet-191	161	23	m.m	m.m	PROPN
admet-191	161	24	.	.	PROPN
admet-191	161	25	carmona	carmona	PROPN
admet-191	161	26	-	-	PUNCT
admet-191	161	27	abellan	abellan	NOUN
admet-191	161	28	,	,	PUNCT
admet-191	161	29	m.	m.	NOUN
admet-191	161	30	riverol	riverol	NOUN
admet-191	161	31	,	,	PUNCT
admet-191	161	32	neurologia	neurologia	PROPN
admet-191	161	33	28	28	NUM
admet-191	161	34	(	(	PUNCT
admet-191	161	35	2013	2013	NUM
admet-191	161	36	)	)	PUNCT
admet-191	161	37	299	299	NUM
admet-191	161	38	-	-	SYM
admet-191	161	39	308	308	NUM
admet-191	161	40	.	.	PUNCT
admet-191	162	1	[	[	X
admet-191	162	2	2	2	NUM
admet-191	162	3	]	]	PUNCT
admet-191	162	4	s.b	s.b	PROPN
admet-191	162	5	.	.	PROPN
admet-191	162	6	prusiner	prusiner	PROPN
admet-191	162	7	,	,	PUNCT
admet-191	162	8	m.r	m.r	PROPN
admet-191	162	9	.	.	PROPN
admet-191	162	10	scott	scott	PROPN
admet-191	162	11	,	,	PUNCT
admet-191	162	12	s.j	s.j	PROPN
admet-191	162	13	.	.	PROPN
admet-191	162	14	dearmond	dearmond	PROPN
admet-191	162	15	,	,	PUNCT
admet-191	162	16	f.e	f.e	PROPN
admet-191	162	17	.	.	PROPN
admet-191	162	18	cohen	cohen	PROPN
admet-191	162	19	,	,	PUNCT
admet-191	162	20	cell	cell	NOUN
admet-191	162	21	93	93	NUM
admet-191	162	22	(	(	PUNCT
admet-191	162	23	1998	1998	NUM
admet-191	162	24	)	)	PUNCT
admet-191	162	25	337	337	NUM
admet-191	162	26	-	-	SYM
admet-191	162	27	348	348	NUM
admet-191	162	28	.	.	PUNCT
admet-191	163	1	[	[	X
admet-191	163	2	3	3	X
admet-191	163	3	]	]	X
admet-191	163	4	k.m	k.m	PROPN
admet-191	163	5	.	.	PROPN
admet-191	163	6	pan	pan	PROPN
admet-191	163	7	,	,	PUNCT
admet-191	163	8	n.	n.	PROPN
admet-191	163	9	stahl	stahl	PROPN
admet-191	163	10	,	,	PUNCT
admet-191	163	11	s.b	s.b	PROPN
admet-191	163	12	.	.	PROPN
admet-191	163	13	prusiner	prusiner	NOUN
admet-191	163	14	,	,	PUNCT
admet-191	163	15	protein	protein	NOUN
admet-191	163	16	sci	sci	PROPN
admet-191	163	17	.	.	PROPN
admet-191	163	18	1	1	NUM
admet-191	163	19	(	(	PUNCT
admet-191	163	20	1992	1992	NUM
admet-191	163	21	)	)	PUNCT
admet-191	163	22	1343	1343	NUM
admet-191	163	23	-	-	SYM
admet-191	163	24	1352	1352	NUM
admet-191	163	25	.	.	PUNCT
admet-191	164	1	[	[	X
admet-191	164	2	4	4	NUM
admet-191	164	3	]	]	PUNCT
admet-191	164	4	m.	m.	NOUN
admet-191	164	5	glatzel	glatzel	PROPN
admet-191	164	6	,	,	PUNCT
admet-191	164	7	k.	k.	PROPN
admet-191	164	8	stoeck	stoeck	PROPN
admet-191	164	9	,	,	PUNCT
admet-191	164	10	h.	h.	PROPN
admet-191	164	11	seeger	seeger	PROPN
admet-191	164	12	,	,	PUNCT
admet-191	164	13	t.	t.	PROPN
admet-191	164	14	luhrs	luhrs	PROPN
admet-191	164	15	,	,	PUNCT
admet-191	164	16	a.	a.	NOUN
admet-191	164	17	aguzzi	aguzzi	PROPN
admet-191	164	18	,	,	PUNCT
admet-191	164	19	arch	arch	NOUN
admet-191	164	20	.	.	PUNCT
admet-191	165	1	neurol	neurol	NOUN
admet-191	165	2	.	.	PUNCT
admet-191	166	1	62	62	NUM
admet-191	166	2	(	(	PUNCT
admet-191	166	3	2005	2005	NUM
admet-191	166	4	)	)	PUNCT
admet-191	166	5	545	545	NUM
admet-191	166	6	-	-	SYM
admet-191	166	7	552	552	NUM
admet-191	166	8	.	.	PUNCT
admet-191	167	1	[	[	X
admet-191	167	2	5	5	NUM
admet-191	167	3	]	]	PUNCT
admet-191	167	4	a.	a.	PROPN
admet-191	167	5	gaeta	gaeta	PROPN
admet-191	167	6	,	,	PUNCT
admet-191	167	7	r.c	r.c	PROPN
admet-191	167	8	.	.	PROPN
admet-191	167	9	hider	hider	PROPN
admet-191	167	10	,	,	PUNCT
admet-191	167	11	br	br	PROPN
admet-191	167	12	.	.	PUNCT
admet-191	167	13	j.	j.	PROPN
admet-191	167	14	pharmacol	pharmacol	PROPN
admet-191	167	15	.	.	PUNCT
admet-191	168	1	146	146	NUM
admet-191	168	2	(	(	PUNCT
admet-191	168	3	2005	2005	NUM
admet-191	168	4	)	)	PUNCT
admet-191	168	5	1041	1041	NUM
admet-191	168	6	-	-	SYM
admet-191	168	7	1059	1059	NUM
admet-191	168	8	.	.	PUNCT
admet-191	169	1	[	[	X
admet-191	169	2	6	6	NUM
admet-191	169	3	]	]	PUNCT
admet-191	169	4	k.	k.	PROPN
admet-191	169	5	hur	hur	PROPN
admet-191	169	6	,	,	PUNCT
admet-191	169	7	j.i	j.i	PROPN
admet-191	169	8	.	.	PROPN
admet-191	169	9	kim	kim	PROPN
admet-191	169	10	,	,	PUNCT
admet-191	169	11	s.i	s.i	PROPN
admet-191	169	12	.	.	PROPN
admet-191	169	13	choi	choi	PROPN
admet-191	169	14	,	,	PUNCT
admet-191	169	15	e.k	e.k	PROPN
admet-191	169	16	.	.	PROPN
admet-191	169	17	choi	choi	PROPN
admet-191	169	18	,	,	PUNCT
admet-191	169	19	r.i	r.i	PROPN
admet-191	169	20	.	.	PROPN
admet-191	169	21	carp	carp	PROPN
admet-191	169	22	,	,	PUNCT
admet-191	169	23	y.s	y.s	PROPN
admet-191	169	24	.	.	PROPN
admet-191	169	25	kim	kim	PROPN
admet-191	169	26	,	,	PUNCT
admet-191	169	27	mech	mech	NOUN
admet-191	169	28	.	.	PUNCT
admet-191	169	29	ageing	age	VERB
admet-191	169	30	dev	dev	PROPN
admet-191	169	31	.	.	PROPN
admet-191	170	1	123	123	NUM
admet-191	170	2	(	(	PUNCT
admet-191	170	3	2002	2002	NUM
admet-191	170	4	)	)	PUNCT
admet-191	170	5	1637	1637	NUM
admet-191	170	6	-	-	SYM
admet-191	170	7	1647	1647	NUM
admet-191	170	8	.	.	PUNCT
admet-191	171	1	[	[	X
admet-191	171	2	7	7	X
admet-191	171	3	]	]	X
admet-191	171	4	h.f	h.f	PROPN
admet-191	171	5	.	.	PROPN
admet-191	172	1	ji	ji	PROPN
admet-191	172	2	,	,	PUNCT
admet-191	172	3	h.y	h.y	PROPN
admet-191	172	4	.	.	PROPN
admet-191	172	5	zhang	zhang	PROPN
admet-191	172	6	,	,	PUNCT
admet-191	172	7	trends	trend	VERB
admet-191	172	8	biochem	biochem	PROPN
admet-191	172	9	.	.	PUNCT
admet-191	173	1	sci	sci	PROPN
admet-191	173	2	.	.	PROPN
admet-191	173	3	35	35	NUM
admet-191	173	4	(	(	PUNCT
admet-191	173	5	2010	2010	NUM
admet-191	173	6	)	)	PUNCT
admet-191	173	7	129	129	NUM
admet-191	173	8	-	-	SYM
admet-191	173	9	134	134	NUM
admet-191	173	10	.	.	PUNCT
admet-191	174	1	[	[	X
admet-191	174	2	8	8	NUM
admet-191	174	3	]	]	PUNCT
admet-191	174	4	p.	p.	NOUN
admet-191	174	5	tiraboschi	tiraboschi	PROPN
admet-191	174	6	,	,	PUNCT
admet-191	174	7	f.	f.	PROPN
admet-191	174	8	tagliavini	tagliavini	PROPN
admet-191	174	9	,	,	PUNCT
admet-191	174	10	nat	nat	PROPN
admet-191	174	11	.	.	PUNCT
admet-191	174	12	rev	rev	PROPN
admet-191	174	13	.	.	PUNCT
admet-191	175	1	neurol	neurol	PROPN
admet-191	175	2	.	.	PUNCT
admet-191	176	1	9	9	NUM
admet-191	176	2	(	(	PUNCT
admet-191	176	3	2013	2013	NUM
admet-191	176	4	)	)	PUNCT
admet-191	176	5	366	366	NUM
admet-191	176	6	-	-	SYM
admet-191	176	7	367	367	NUM
admet-191	176	8	.	.	PUNCT
admet-191	177	1	[	[	X
admet-191	177	2	9	9	NUM
admet-191	177	3	]	]	X
admet-191	177	4	p.e	p.e	PROPN
admet-191	177	5	.	.	PROPN
admet-191	177	6	fraser	fraser	PROPN
admet-191	177	7	,	,	PUNCT
admet-191	177	8	j.	j.	PROPN
admet-191	177	9	biol	biol	PROPN
admet-191	177	10	.	.	PUNCT
admet-191	178	1	chem	chem	NOUN
admet-191	178	2	.	.	PUNCT
admet-191	179	1	289	289	NUM
admet-191	179	2	(	(	PUNCT
admet-191	179	3	2014	2014	NUM
admet-191	179	4	)	)	PUNCT
admet-191	179	5	19839	19839	NUM
admet-191	179	6	-	-	SYM
admet-191	179	7	19840	19840	NUM
admet-191	179	8	.	.	PUNCT
admet-191	180	1	[	[	X
admet-191	180	2	10	10	NUM
admet-191	180	3	]	]	X
admet-191	180	4	v.c	v.c	PROPN
admet-191	180	5	.	.	PROPN
admet-191	180	6	dodelet	dodelet	PROPN
admet-191	180	7	,	,	PUNCT
admet-191	180	8	n.	n.	PROPN
admet-191	180	9	r.	r.	PROPN
admet-191	180	10	cashman	cashman	PROPN
admet-191	180	11	,	,	PUNCT
admet-191	180	12	blood	blood	NOUN
admet-191	180	13	91	91	NUM
admet-191	180	14	(	(	PUNCT
admet-191	180	15	1998	1998	NUM
admet-191	180	16	)	)	PUNCT
admet-191	180	17	1556	1556	NUM
admet-191	180	18	-	-	SYM
admet-191	180	19	1561	1561	NUM
admet-191	180	20	.	.	PUNCT
admet-191	181	1	[	[	X
admet-191	181	2	11	11	NUM
admet-191	181	3	]	]	X
admet-191	181	4	s.b	s.b	PROPN
admet-191	181	5	.	.	PROPN
admet-191	181	6	prusiner	prusiner	NOUN
admet-191	181	7	,	,	PUNCT
admet-191	181	8	science	science	NOUN
admet-191	181	9	252	252	NUM
admet-191	181	10	(	(	PUNCT
admet-191	181	11	1991	1991	NUM
admet-191	181	12	)	)	PUNCT
admet-191	181	13	1515	1515	NUM
admet-191	181	14	-	-	SYM
admet-191	181	15	1522	1522	NUM
admet-191	181	16	.	.	PUNCT
admet-191	182	1	[	[	X
admet-191	182	2	12	12	NUM
admet-191	182	3	]	]	X
admet-191	182	4	h.	h.	PROPN
admet-191	182	5	kretzschmar	kretzschmar	PROPN
admet-191	182	6	,	,	PUNCT
admet-191	182	7	j.	j.	PROPN
admet-191	182	8	tatzelt	tatzelt	PROPN
admet-191	182	9	,	,	PUNCT
admet-191	182	10	brain	brain	NOUN
admet-191	182	11	pathol	pathol	NOUN
admet-191	182	12	.	.	PUNCT
admet-191	183	1	23	23	NUM
admet-191	183	2	(	(	PUNCT
admet-191	183	3	2013	2013	NUM
admet-191	183	4	)	)	PUNCT
admet-191	183	5	321	321	NUM
admet-191	183	6	-	-	SYM
admet-191	183	7	332	332	NUM
admet-191	183	8	.	.	PUNCT
admet-191	184	1	[	[	X
admet-191	184	2	13	13	NUM
admet-191	184	3	]	]	X
admet-191	184	4	d.r	d.r	PROPN
admet-191	184	5	.	.	PROPN
admet-191	184	6	brown	brown	PROPN
admet-191	184	7	,	,	PUNCT
admet-191	184	8	w.j	w.j	PROPN
admet-191	184	9	.	.	PROPN
admet-191	184	10	schulzschaeffer	schulzschaeffer	PROPN
admet-191	184	11	,	,	PUNCT
admet-191	184	12	b.	b.	PROPN
admet-191	184	13	schmidt	schmidt	PROPN
admet-191	184	14	,	,	PUNCT
admet-191	184	15	h.a	h.a	PROPN
admet-191	184	16	.	.	PROPN
admet-191	184	17	kretzschmar	kretzschmar	PROPN
admet-191	184	18	,	,	PUNCT
admet-191	184	19	exp	exp	NOUN
admet-191	184	20	.	.	PUNCT
admet-191	184	21	neurol	neurol	PROPN
admet-191	184	22	.	.	PUNCT
admet-191	185	1	146	146	NUM
admet-191	185	2	(	(	PUNCT
admet-191	185	3	1997	1997	NUM
admet-191	185	4	)	)	PUNCT
admet-191	185	5	104	104	NUM
admet-191	185	6	-	-	SYM
admet-191	185	7	112	112	NUM
admet-191	185	8	.	.	PUNCT
admet-191	186	1	[	[	X
admet-191	186	2	14	14	NUM
admet-191	186	3	]	]	PUNCT
admet-191	186	4	p.	p.	NOUN
admet-191	186	5	sobrova	sobrova	PROPN
admet-191	186	6	,	,	PUNCT
admet-191	186	7	m.	m.	PROPN
admet-191	186	8	ryvolova	ryvolova	PROPN
admet-191	186	9	,	,	PUNCT
admet-191	186	10	v.	v.	ADP
admet-191	186	11	adam	adam	PROPN
admet-191	186	12	,	,	PUNCT
admet-191	186	13	r.	r.	PROPN
admet-191	186	14	kizek	kizek	PROPN
admet-191	186	15	,	,	PUNCT
admet-191	186	16	electrophoresis	electrophoresis	NOUN
admet-191	186	17	33	33	NUM
admet-191	186	18	(	(	PUNCT
admet-191	186	19	2012	2012	NUM
admet-191	186	20	)	)	PUNCT
admet-191	186	21	3644	3644	NUM
admet-191	186	22	-	-	SYM
admet-191	186	23	3652	3652	NUM
admet-191	186	24	.	.	PUNCT
admet-191	187	1	[	[	X
admet-191	187	2	15	15	NUM
admet-191	187	3	]	]	PUNCT
admet-191	187	4	p.	p.	NOUN
admet-191	187	5	sobrova	sobrova	PROPN
admet-191	187	6	,	,	PUNCT
admet-191	187	7	m.	m.	PROPN
admet-191	187	8	ryvolova	ryvolova	PROPN
admet-191	187	9	,	,	PUNCT
admet-191	187	10	d.	d.	PROPN
admet-191	187	11	hynek	hynek	PROPN
admet-191	187	12	,	,	PUNCT
admet-191	187	13	v.	v.	ADP
admet-191	187	14	adam	adam	PROPN
admet-191	187	15	,	,	PUNCT
admet-191	187	16	j.	j.	PROPN
admet-191	187	17	hubalek	hubalek	PROPN
admet-191	187	18	,	,	PUNCT
admet-191	187	19	r.	r.	PROPN
admet-191	187	20	kizek	kizek	PROPN
admet-191	187	21	,	,	PUNCT
admet-191	187	22	int	int	PROPN
admet-191	187	23	.	.	PUNCT
admet-191	188	1	j.	j.	PROPN
admet-191	188	2	electrochem	electrochem	PROPN
admet-191	188	3	.	.	PUNCT
admet-191	189	1	sci	sci	PROPN
admet-191	189	2	.	.	PROPN
admet-191	189	3	7	7	NUM
admet-191	189	4	(	(	PUNCT
admet-191	189	5	2012	2012	NUM
admet-191	189	6	)	)	PUNCT
admet-191	189	7	928	928	NUM
admet-191	189	8	-	-	SYM
admet-191	189	9	942	942	NUM
admet-191	189	10	.	.	PUNCT
admet-191	190	1	[	[	X
admet-191	190	2	16	16	NUM
admet-191	190	3	]	]	PUNCT
admet-191	190	4	p.	p.	NOUN
admet-191	190	5	sobrova	sobrova	PROPN
admet-191	190	6	,	,	PUNCT
admet-191	190	7	i.	i.	PROPN
admet-191	190	8	blazkova	blazkova	PROPN
admet-191	190	9	,	,	PUNCT
admet-191	190	10	j.	j.	PROPN
admet-191	190	11	chomoucka	chomoucka	PROPN
admet-191	190	12	,	,	PUNCT
admet-191	190	13	j.	j.	PROPN
admet-191	190	14	drbohlavova	drbohlavova	PROPN
admet-191	190	15	,	,	PUNCT
admet-191	190	16	m.	m.	NOUN
admet-191	190	17	vaculovicova	vaculovicova	PROPN
admet-191	190	18	,	,	PUNCT
admet-191	190	19	p.	p.	PROPN
admet-191	190	20	kopel	kopel	PROPN
admet-191	190	21	,	,	PUNCT
admet-191	190	22	j.	j.	PROPN
admet-191	190	23	hubalek	hubalek	PROPN
admet-191	190	24	,	,	PUNCT
admet-191	190	25	r.	r.	PROPN
admet-191	190	26	kizek	kizek	PROPN
admet-191	190	27	,	,	PUNCT
admet-191	190	28	v.	v.	ADP
admet-191	190	29	adam	adam	PROPN
admet-191	190	30	,	,	PUNCT
admet-191	190	31	prion	prion	NOUN
admet-191	190	32	7	7	NUM
admet-191	190	33	(	(	PUNCT
admet-191	190	34	2013	2013	NUM
admet-191	190	35	)	)	PUNCT
admet-191	190	36	349	349	NUM
admet-191	190	37	-	-	SYM
admet-191	190	38	358	358	NUM
admet-191	190	39	.	.	PUNCT
admet-191	191	1	[	[	X
admet-191	191	2	17	17	NUM
admet-191	191	3	]	]	PUNCT
admet-191	191	4	p.	p.	NOUN
admet-191	191	5	sobrova	sobrova	PROPN
admet-191	191	6	,	,	PUNCT
admet-191	191	7	m.	m.	PROPN
admet-191	191	8	ryvolova	ryvolova	PROPN
admet-191	191	9	,	,	PUNCT
admet-191	191	10	v.	v.	PROPN
admet-191	191	11	pekarik	pekarik	PROPN
admet-191	191	12	,	,	PUNCT
admet-191	191	13	j.	j.	PROPN
admet-191	191	14	hubalek	hubalek	PROPN
admet-191	191	15	,	,	PUNCT
admet-191	191	16	v.	v.	ADP
admet-191	191	17	adam	adam	PROPN
admet-191	191	18	,	,	PUNCT
admet-191	191	19	r.	r.	PROPN
admet-191	191	20	kizek	kizek	PROPN
admet-191	191	21	,	,	PUNCT
admet-191	191	22	int	int	PROPN
admet-191	191	23	.	.	PUNCT
admet-191	192	1	j.	j.	PROPN
admet-191	192	2	electrochem	electrochem	PROPN
admet-191	192	3	.	.	PUNCT
admet-191	193	1	sci	sci	PROPN
admet-191	193	2	.	.	PROPN
admet-191	193	3	8	8	NUM
admet-191	193	4	(	(	PUNCT
admet-191	193	5	2013	2013	NUM
admet-191	193	6	)	)	PUNCT
admet-191	193	7	12466	12466	NUM
admet-191	193	8	-	-	SYM
admet-191	193	9	12475	12475	NUM
admet-191	193	10	.	.	PUNCT
admet-191	194	1	[	[	X
admet-191	194	2	18	18	NUM
admet-191	194	3	]	]	PUNCT
admet-191	194	4	a.	a.	NOUN
admet-191	194	5	cardova	cardova	PROPN
admet-191	194	6	,	,	PUNCT
admet-191	194	7	p.	p.	PROPN
admet-191	194	8	sobrova	sobrova	PROPN
admet-191	194	9	,	,	PUNCT
admet-191	194	10	r.	r.	PROPN
admet-191	194	11	bujdoso	bujdoso	PROPN
admet-191	194	12	,	,	PUNCT
admet-191	194	13	v.	v.	CCONJ
admet-191	194	14	adam	adam	PROPN
admet-191	194	15	,	,	PUNCT
admet-191	194	16	r.	r.	PROPN
admet-191	194	17	kizek	kizek	PROPN
admet-191	194	18	,	,	PUNCT
admet-191	194	19	j.	j.	PROPN
admet-191	194	20	metallomics	metallomics	PROPN
admet-191	194	21	nanotech	nanotech	PROPN
admet-191	194	22	.	.	PROPN
admet-191	194	23	1	1	NUM
admet-191	194	24	(	(	PUNCT
admet-191	194	25	2014	2014	NUM
admet-191	194	26	)	)	PUNCT
admet-191	194	27	27	27	NUM
admet-191	194	28	-	-	SYM
admet-191	194	29	29	29	NUM
admet-191	194	30	.	.	PUNCT
admet-191	195	1	[	[	X
admet-191	195	2	19	19	NUM
admet-191	195	3	]	]	X
admet-191	195	4	e.	e.	PROPN
admet-191	195	5	sedlackova	sedlackova	PROPN
admet-191	195	6	,	,	PUNCT
admet-191	195	7	a.	a.	PROPN
admet-191	195	8	cardova	cardova	PROPN
admet-191	195	9	,	,	PUNCT
admet-191	195	10	v.	v.	ADP
admet-191	195	11	adam	adam	PROPN
admet-191	195	12	,	,	PUNCT
admet-191	195	13	r.	r.	PROPN
admet-191	195	14	kizek	kizek	PROPN
admet-191	195	15	,	,	PUNCT
admet-191	195	16	j.	j.	PROPN
admet-191	195	17	metallomics	metallomics	PROPN
admet-191	195	18	nanotech	nanotech	PROPN
admet-191	195	19	.	.	PROPN
admet-191	195	20	1	1	NUM
admet-191	195	21	(	(	PUNCT
admet-191	195	22	2014	2014	NUM
admet-191	195	23	)	)	PUNCT
admet-191	195	24	23	23	NUM
admet-191	195	25	-	-	SYM
admet-191	195	26	26	26	NUM
admet-191	195	27	.	.	PUNCT
admet-191	196	1	[	[	X
admet-191	196	2	20	20	NUM
admet-191	196	3	]	]	X
admet-191	196	4	c.	c.	PROPN
admet-191	196	5	cirelli	cirelli	PROPN
admet-191	196	6	,	,	PUNCT
admet-191	196	7	g.	g.	PROPN
admet-191	196	8	tononi	tononi	PROPN
admet-191	196	9	,	,	PUNCT
admet-191	196	10	brain	brain	NOUN
admet-191	196	11	res	re	NOUN
admet-191	196	12	.	.	PROPN
admet-191	196	13	885	885	NUM
admet-191	196	14	(	(	PUNCT
admet-191	196	15	2000	2000	NUM
admet-191	196	16	)	)	PUNCT
admet-191	196	17	303	303	NUM
admet-191	196	18	-	-	SYM
admet-191	196	19	321	321	NUM
admet-191	196	20	.	.	PUNCT
admet-191	197	1	[	[	X
admet-191	197	2	21	21	NUM
admet-191	197	3	]	]	X
admet-191	197	4	g.	g.	PROPN
admet-191	197	5	meloni	meloni	PROPN
admet-191	197	6	,	,	PUNCT
admet-191	197	7	v.	v.	ADP
admet-191	197	8	sonois	sonois	NOUN
admet-191	197	9	,	,	PUNCT
admet-191	197	10	t.	t.	PROPN
admet-191	197	11	delaine	delaine	PROPN
admet-191	197	12	,	,	PUNCT
admet-191	197	13	l.	l.	PROPN
admet-191	197	14	guilloreau	guilloreau	PROPN
admet-191	197	15	,	,	PUNCT
admet-191	197	16	a.	a.	NOUN
admet-191	197	17	gillet	gillet	PROPN
admet-191	197	18	,	,	PUNCT
admet-191	197	19	j.	j.	PROPN
admet-191	197	20	teissie	teissie	PROPN
admet-191	197	21	,	,	PUNCT
admet-191	197	22	p.	p.	NOUN
admet-191	197	23	faller	faller	NOUN
admet-191	197	24	,	,	PUNCT
admet-191	197	25	m.	m.	NOUN
admet-191	197	26	vasak	vasak	PROPN
admet-191	197	27	,	,	PUNCT
admet-191	197	28	nat	nat	PROPN
admet-191	197	29	.	.	PUNCT
admet-191	198	1	chem	chem	PROPN
admet-191	198	2	.	.	PUNCT
admet-191	199	1	biol	biol	PROPN
admet-191	199	2	.	.	PUNCT
admet-191	200	1	4	4	NUM
admet-191	200	2	(	(	PUNCT
admet-191	200	3	2008	2008	NUM
admet-191	200	4	)	)	PUNCT
admet-191	200	5	366	366	NUM
admet-191	200	6	-	-	SYM
admet-191	200	7	372	372	NUM
admet-191	200	8	.	.	PUNCT
admet-191	201	1	[	[	X
admet-191	201	2	22	22	NUM
admet-191	201	3	]	]	PUNCT
admet-191	201	4	m.	m.	NOUN
admet-191	201	5	vasak	vasak	NOUN
admet-191	201	6	,	,	PUNCT
admet-191	201	7	d.w	d.w	PROPN
admet-191	201	8	.	.	PROPN
admet-191	201	9	hasler	hasler	PROPN
admet-191	201	10	,	,	PUNCT
admet-191	201	11	curr	curr	PROPN
admet-191	201	12	.	.	PUNCT
admet-191	202	1	opin	opin	NOUN
admet-191	202	2	.	.	PUNCT
admet-191	203	1	chem	chem	NOUN
admet-191	203	2	.	.	PUNCT
admet-191	204	1	biol	biol	PROPN
admet-191	204	2	.	.	PUNCT
admet-191	205	1	4	4	NUM
admet-191	205	2	(	(	PUNCT
admet-191	205	3	2000	2000	NUM
admet-191	205	4	)	)	PUNCT
admet-191	205	5	177	177	NUM
admet-191	205	6	-	-	SYM
admet-191	205	7	183	183	NUM
admet-191	205	8	.	.	PUNCT
admet-191	206	1	©	©	PROPN
admet-191	206	2	2015	2015	NUM
admet-191	206	3	by	by	ADP
admet-191	206	4	the	the	DET
admet-191	206	5	authors	author	NOUN
admet-191	206	6	;	;	PUNCT
admet-191	206	7	licensee	licensee	PROPN
admet-191	206	8	iapc	iapc	PROPN
admet-191	206	9	,	,	PUNCT
admet-191	206	10	zagreb	zagreb	PROPN
admet-191	206	11	,	,	PUNCT
admet-191	206	12	croatia	croatia	PROPN
admet-191	206	13	.	.	PUNCT
admet-191	207	1	this	this	DET
admet-191	207	2	article	article	NOUN
admet-191	207	3	is	be	AUX
admet-191	207	4	an	an	DET
admet-191	207	5	open	open	ADJ
admet-191	207	6	-	-	PUNCT
admet-191	207	7	access	access	NOUN
admet-191	207	8	article	article	NOUN
admet-191	207	9	distributed	distribute	VERB
admet-191	207	10	under	under	ADP
admet-191	207	11	the	the	DET
admet-191	207	12	terms	term	NOUN
admet-191	207	13	and	and	CCONJ
admet-191	207	14	conditions	condition	NOUN
admet-191	207	15	of	of	ADP
admet-191	207	16	the	the	DET
admet-191	207	17	creative	creative	ADJ
admet-191	207	18	commons	common	NOUN
admet-191	207	19	attribution	attribution	NOUN
admet-191	207	20	license	license	NOUN
admet-191	207	21	(	(	PUNCT
admet-191	207	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-191	207	23	)	)	PUNCT
admet-191	207	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN