id	sid	tid	token	lemma	pos
admet-193	1	1	manuscript	manuscript	PROPN
admet-193	1	2	doi	doi	PROPN
admet-193	1	3	:	:	PUNCT
admet-193	1	4	10.5599	10.5599	NUM
admet-193	1	5	/	/	SYM
admet-193	1	6	admet.3.2.193	admet.3.2.193	PROPN
admet-193	1	7	84	84	NUM
admet-193	1	8	admet	admet	NOUN
admet-193	1	9	&	&	CCONJ
admet-193	1	10	dmpk	dmpk	PROPN
admet-193	1	11	3(2	3(2	NUM
admet-193	1	12	)	)	PUNCT
admet-193	1	13	(	(	PUNCT
admet-193	1	14	2015	2015	NUM
admet-193	1	15	)	)	PUNCT
admet-193	1	16	84	84	NUM
admet-193	1	17	-	-	SYM
admet-193	1	18	109	109	NUM
admet-193	1	19	;	;	PUNCT
admet-193	1	20	doi	doi	NOUN
admet-193	1	21	:	:	PUNCT
admet-193	1	22	10.5599	10.5599	NUM
admet-193	1	23	/	/	SYM
admet-193	1	24	admet.3.2.193	admet.3.2.193	ADJ
admet-193	1	25	open	open	ADJ
admet-193	1	26	access	access	NOUN
admet-193	1	27	:	:	PUNCT
admet-193	1	28	issn	issn	PROPN
admet-193	1	29	:	:	PUNCT
admet-193	1	30	1848	1848	NUM
admet-193	1	31	-	-	SYM
admet-193	1	32	7718	7718	NUM
admet-193	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-193	1	34	review	review	NOUN
admet-193	1	35	suggested	suggest	VERB
admet-193	1	36	improvements	improvement	NOUN
admet-193	1	37	for	for	ADP
admet-193	1	38	measurement	measurement	NOUN
admet-193	1	39	of	of	ADP
admet-193	1	40	equilibrium	equilibrium	NOUN
admet-193	1	41	solubility	solubility	NOUN
admet-193	1	42	-	-	PUNCT
admet-193	1	43	ph	ph	NOUN
admet-193	1	44	of	of	ADP
admet-193	1	45	ionizable	ionizable	ADJ
admet-193	1	46	drugs	drug	NOUN
admet-193	1	47	alex	alex	PROPN
admet-193	1	48	avdeef	avdeef	PROPN
admet-193	1	49	in	in	ADP
admet-193	1	50	-	-	PUNCT
admet-193	1	51	adme	adme	NOUN
admet-193	1	52	research	research	NOUN
admet-193	1	53	,	,	PUNCT
admet-193	1	54	1732	1732	NUM
admet-193	1	55	first	first	ADJ
admet-193	1	56	avenue	avenue	PROPN
admet-193	1	57	#	#	SYM
admet-193	1	58	102	102	NUM
admet-193	1	59	,	,	PUNCT
admet-193	1	60	new	new	PROPN
admet-193	1	61	york	york	PROPN
admet-193	1	62	,	,	PUNCT
admet-193	1	63	ny	ny	PROPN
admet-193	1	64	10128	10128	NUM
admet-193	1	65	usa	usa	PROPN
admet-193	1	66	corresponding	corresponding	PROPN
admet-193	1	67	author	author	NOUN
admet-193	1	68	:	:	PUNCT
admet-193	1	69	e	e	NOUN
admet-193	1	70	-	-	NOUN
admet-193	1	71	mail	mail	NOUN
admet-193	1	72	:	:	PUNCT
admet-193	1	73	alex@in-adme.com	alex@in-adme.com	NOUN
admet-193	1	74	;	;	PUNCT
admet-193	1	75	tel	tel	PROPN
admet-193	1	76	.	.	PUNCT
admet-193	1	77	:	:	PUNCT
admet-193	2	1	+1	+1	PROPN
admet-193	2	2	-	-	PUNCT
admet-193	2	3	646	646	NUM
admet-193	2	4	-	-	PUNCT
admet-193	2	5	678	678	NUM
admet-193	2	6	-	-	SYM
admet-193	2	7	5713	5713	NUM
admet-193	2	8	received	receive	VERB
admet-193	2	9	:	:	PUNCT
admet-193	2	10	june	june	PROPN
admet-193	2	11	14	14	NUM
admet-193	2	12	,	,	PUNCT
admet-193	2	13	2015	2015	NUM
admet-193	2	14	;	;	PUNCT
admet-193	2	15	revised	revise	VERB
admet-193	2	16	:	:	PUNCT
admet-193	2	17	june	june	PROPN
admet-193	2	18	22	22	NUM
admet-193	2	19	,	,	PUNCT
admet-193	2	20	2015	2015	NUM
admet-193	2	21	;	;	PUNCT
admet-193	2	22	published	publish	VERB
admet-193	2	23	:	:	PUNCT
admet-193	2	24	july	july	PROPN
admet-193	2	25	01	01	NUM
admet-193	2	26	,	,	PUNCT
admet-193	2	27	2015	2015	NUM
admet-193	2	28	abstract	abstract	NOUN
admet-193	2	29	the	the	DET
admet-193	2	30	accurate	accurate	ADJ
admet-193	2	31	prediction	prediction	NOUN
admet-193	2	32	of	of	ADP
admet-193	2	33	solubility	solubility	NOUN
admet-193	2	34	of	of	ADP
admet-193	2	35	drug	drug	NOUN
admet-193	2	36	-	-	PUNCT
admet-193	2	37	like	like	ADJ
admet-193	2	38	molecules	molecule	NOUN
admet-193	2	39	is	be	AUX
admet-193	2	40	difficult	difficult	ADJ
admet-193	2	41	,	,	PUNCT
admet-193	2	42	and	and	CCONJ
admet-193	2	43	perhaps	perhaps	ADV
admet-193	2	44	a	a	DET
admet-193	2	45	satisfactory	satisfactory	ADJ
admet-193	2	46	general	general	ADJ
admet-193	2	47	model	model	NOUN
admet-193	2	48	is	be	AUX
admet-193	2	49	not	not	PART
admet-193	2	50	yet	yet	ADV
admet-193	2	51	available	available	ADJ
admet-193	2	52	.	.	PUNCT
admet-193	3	1	the	the	DET
admet-193	3	2	most	most	ADV
admet-193	3	3	cited	cite	VERB
admet-193	3	4	challenge	challenge	NOUN
admet-193	3	5	to	to	ADP
admet-193	3	6	good	good	ADJ
admet-193	3	7	prediction	prediction	NOUN
admet-193	3	8	has	have	AUX
admet-193	3	9	been	be	AUX
admet-193	3	10	the	the	DET
admet-193	3	11	lack	lack	NOUN
admet-193	3	12	of	of	ADP
admet-193	3	13	enough	enough	ADJ
admet-193	3	14	highquality	highquality	NOUN
admet-193	3	15	and	and	CCONJ
admet-193	3	16	drug	drug	NOUN
admet-193	3	17	-	-	PUNCT
admet-193	3	18	relevant	relevant	ADJ
admet-193	3	19	solubility	solubility	NOUN
admet-193	3	20	data	datum	NOUN
admet-193	3	21	that	that	PRON
admet-193	3	22	adequately	adequately	ADV
admet-193	3	23	cover	cover	VERB
admet-193	3	24	the	the	DET
admet-193	3	25	chemical	chemical	ADJ
admet-193	3	26	space	space	NOUN
admet-193	3	27	of	of	ADP
admet-193	3	28	drugs	drug	NOUN
admet-193	3	29	.	.	PUNCT
admet-193	4	1	this	this	DET
admet-193	4	2	review	review	NOUN
admet-193	4	3	addresses	address	VERB
admet-193	4	4	data	datum	NOUN
admet-193	4	5	quality	quality	NOUN
admet-193	4	6	in	in	ADP
admet-193	4	7	solubility	solubility	NOUN
admet-193	4	8	measurement	measurement	NOUN
admet-193	4	9	.	.	PUNCT
admet-193	5	1	specifically	specifically	ADV
admet-193	5	2	,	,	PUNCT
admet-193	5	3	the	the	DET
admet-193	5	4	“	"	PUNCT
admet-193	5	5	gold	gold	ADJ
admet-193	5	6	standard	standard	NOUN
admet-193	5	7	”	"	PUNCT
admet-193	5	8	shake	shake	NOUN
admet-193	5	9	-	-	PUNCT
admet-193	5	10	flask	flask	NOUN
admet-193	5	11	and	and	CCONJ
admet-193	5	12	related	related	ADJ
admet-193	5	13	methods	method	NOUN
admet-193	5	14	used	use	VERB
admet-193	5	15	to	to	PART
admet-193	5	16	measure	measure	VERB
admet-193	5	17	equilibrium	equilibrium	NOUN
admet-193	5	18	solubility	solubility	NOUN
admet-193	5	19	of	of	ADP
admet-193	5	20	ionizable	ionizable	ADJ
admet-193	5	21	drug	drug	NOUN
admet-193	5	22	-	-	PUNCT
admet-193	5	23	like	like	ADJ
admet-193	5	24	compounds	compound	NOUN
admet-193	5	25	as	as	ADP
admet-193	5	26	a	a	DET
admet-193	5	27	function	function	NOUN
admet-193	5	28	of	of	ADP
admet-193	5	29	ph	ph	NOUN
admet-193	5	30	were	be	AUX
admet-193	5	31	reviewed	review	VERB
admet-193	5	32	.	.	PUNCT
admet-193	6	1	over	over	ADP
admet-193	6	2	800	800	NUM
admet-193	6	3	publications	publication	NOUN
admet-193	6	4	were	be	AUX
admet-193	6	5	examined	examine	VERB
admet-193	6	6	.	.	PUNCT
admet-193	7	1	many	many	ADJ
admet-193	7	2	factors	factor	NOUN
admet-193	7	3	affecting	affect	VERB
admet-193	7	4	the	the	DET
admet-193	7	5	quality	quality	NOUN
admet-193	7	6	of	of	ADP
admet-193	7	7	the	the	DET
admet-193	7	8	measurement	measurement	NOUN
admet-193	7	9	were	be	AUX
admet-193	7	10	recognized	recognize	VERB
admet-193	7	11	,	,	PUNCT
admet-193	7	12	and	and	CCONJ
admet-193	7	13	a	a	DET
admet-193	7	14	number	number	NOUN
admet-193	7	15	of	of	ADP
admet-193	7	16	suggestions	suggestion	NOUN
admet-193	7	17	are	be	AUX
admet-193	7	18	offered	offer	VERB
admet-193	7	19	to	to	PART
admet-193	7	20	improve	improve	VERB
admet-193	7	21	the	the	DET
admet-193	7	22	experimental	experimental	ADJ
admet-193	7	23	methodology	methodology	NOUN
admet-193	7	24	.	.	PUNCT
admet-193	8	1	some	some	PRON
admet-193	8	2	of	of	ADP
admet-193	8	3	the	the	DET
admet-193	8	4	suggestions	suggestion	NOUN
admet-193	8	5	focus	focus	VERB
admet-193	8	6	on	on	ADP
admet-193	8	7	improving	improve	VERB
admet-193	8	8	methods	method	NOUN
admet-193	8	9	for	for	ADP
admet-193	8	10	future	future	ADJ
admet-193	8	11	measurements	measurement	NOUN
admet-193	8	12	,	,	PUNCT
admet-193	8	13	and	and	CCONJ
admet-193	8	14	some	some	PRON
admet-193	8	15	refer	refer	VERB
admet-193	8	16	to	to	ADP
admet-193	8	17	improvements	improvement	NOUN
admet-193	8	18	in	in	ADP
admet-193	8	19	data	datum	NOUN
admet-193	8	20	mining	mining	NOUN
admet-193	8	21	,	,	PUNCT
admet-193	8	22	i.e.	i.e.	X
admet-193	8	23	,	,	PUNCT
admet-193	8	24	to	to	ADP
admet-193	8	25	ways	way	NOUN
admet-193	8	26	of	of	ADP
admet-193	8	27	extracting	extract	VERB
admet-193	8	28	more	more	ADV
admet-193	8	29	reliable	reliable	ADJ
admet-193	8	30	information	information	NOUN
admet-193	8	31	from	from	ADP
admet-193	8	32	existing	exist	VERB
admet-193	8	33	data	datum	NOUN
admet-193	8	34	.	.	PUNCT
admet-193	9	1	by	by	ADP
admet-193	9	2	normalizing	normalize	VERB
admet-193	9	3	data	datum	NOUN
admet-193	9	4	for	for	ADP
admet-193	9	5	ph	ph	PROPN
admet-193	9	6	(	(	PUNCT
admet-193	9	7	i.e.	i.e.	X
admet-193	9	8	,	,	PUNCT
admet-193	9	9	deriving	derive	VERB
admet-193	9	10	intrinsic	intrinsic	ADJ
admet-193	9	11	solubility	solubility	NOUN
admet-193	9	12	,	,	PUNCT
admet-193	9	13	s0	s0	PROPN
admet-193	9	14	)	)	PUNCT
admet-193	9	15	and	and	CCONJ
admet-193	9	16	for	for	ADP
admet-193	9	17	temperature	temperature	NOUN
admet-193	9	18	(	(	PUNCT
admet-193	9	19	by	by	ADP
admet-193	9	20	transforming	transform	VERB
admet-193	9	21	measurements	measurement	NOUN
admet-193	9	22	performed	perform	VERB
admet-193	9	23	in	in	ADP
admet-193	9	24	the	the	DET
admet-193	9	25	range	range	NOUN
admet-193	9	26	20	20	NUM
admet-193	9	27	–	–	SYM
admet-193	9	28	40	40	NUM
admet-193	9	29	°	°	ADP
admet-193	9	30	c	c	NOUN
admet-193	9	31	to	to	ADP
admet-193	9	32	25	25	NUM
admet-193	9	33	°	°	NOUN
admet-193	9	34	c	c	NOUN
admet-193	9	35	)	)	PUNCT
admet-193	9	36	,	,	PUNCT
admet-193	9	37	it	it	PRON
admet-193	9	38	is	be	AUX
admet-193	9	39	suggested	suggest	VERB
admet-193	9	40	that	that	SCONJ
admet-193	9	41	the	the	DET
admet-193	9	42	0.6	0.6	NUM
admet-193	9	43	-	-	SYM
admet-193	9	44	0.7	0.7	NUM
admet-193	9	45	log	log	NOUN
admet-193	9	46	unit	unit	NOUN
admet-193	9	47	currently	currently	ADV
admet-193	9	48	expected	expect	VERB
admet-193	9	49	interlaboratory	interlaboratory	ADJ
admet-193	9	50	reproducibility	reproducibility	NOUN
admet-193	9	51	can	can	AUX
admet-193	9	52	be	be	AUX
admet-193	9	53	reduced	reduce	VERB
admet-193	9	54	to	to	ADP
admet-193	9	55	near	near	ADP
admet-193	9	56	0.15	0.15	NUM
admet-193	9	57	.	.	PUNCT
admet-193	10	1	it	it	PRON
admet-193	10	2	is	be	AUX
admet-193	10	3	the	the	DET
admet-193	10	4	aim	aim	NOUN
admet-193	10	5	of	of	ADP
admet-193	10	6	the	the	DET
admet-193	10	7	review	review	NOUN
admet-193	10	8	that	that	SCONJ
admet-193	10	9	the	the	DET
admet-193	10	10	improvements	improvement	NOUN
admet-193	10	11	in	in	ADP
admet-193	10	12	data	datum	NOUN
admet-193	10	13	quality	quality	NOUN
admet-193	10	14	would	would	AUX
admet-193	10	15	lead	lead	VERB
admet-193	10	16	to	to	ADP
admet-193	10	17	better	well	ADJ
admet-193	10	18	predictions	prediction	NOUN
admet-193	10	19	of	of	ADP
admet-193	10	20	drug	drug	NOUN
admet-193	10	21	solubility	solubility	NOUN
admet-193	10	22	using	use	VERB
admet-193	10	23	in	in	ADP
admet-193	10	24	silico	silico	NOUN
admet-193	10	25	methods	method	NOUN
admet-193	10	26	.	.	PUNCT
admet-193	11	1	keywords	keyword	NOUN
admet-193	11	2	shake	shake	NOUN
admet-193	11	3	-	-	PUNCT
admet-193	11	4	flask	flask	NOUN
admet-193	11	5	solubility	solubility	NOUN
admet-193	11	6	;	;	PUNCT
admet-193	11	7	intrinsic	intrinsic	ADJ
admet-193	11	8	solubility	solubility	NOUN
admet-193	11	9	;	;	PUNCT
admet-193	11	10	henderson	henderson	PROPN
admet-193	11	11	-	-	PUNCT
admet-193	11	12	hasselbalch	hasselbalch	PROPN
admet-193	11	13	equation	equation	NOUN
admet-193	11	14	;	;	PUNCT
admet-193	11	15	aggregates	aggregate	NOUN
admet-193	11	16	;	;	PUNCT
admet-193	11	17	oligomers	oligomer	NOUN
admet-193	11	18	;	;	PUNCT
admet-193	11	19	micelles	micelle	NOUN
admet-193	11	20	.	.	PUNCT
admet-193	12	1	introduction	introduction	NOUN
admet-193	12	2	since	since	SCONJ
admet-193	12	3	the	the	DET
admet-193	12	4	mid-1990s	mid-1990	NOUN
admet-193	12	5	there	there	PRON
admet-193	12	6	has	have	AUX
admet-193	12	7	been	be	AUX
admet-193	12	8	a	a	DET
admet-193	12	9	heightened	heightened	ADJ
admet-193	12	10	effort	effort	NOUN
admet-193	12	11	in	in	ADP
admet-193	12	12	drug	drug	NOUN
admet-193	12	13	discovery	discovery	NOUN
admet-193	12	14	to	to	PART
admet-193	12	15	predict	predict	VERB
admet-193	12	16	drug	drug	NOUN
admet-193	12	17	-	-	PUNCT
admet-193	12	18	relevant	relevant	ADJ
admet-193	12	19	aqueous	aqueous	ADJ
admet-193	12	20	solubility	solubility	NOUN
admet-193	12	21	,	,	PUNCT
admet-193	12	22	described	describe	VERB
admet-193	12	23	in	in	ADP
admet-193	12	24	at	at	ADV
admet-193	12	25	least	least	ADJ
admet-193	12	26	a	a	DET
admet-193	12	27	hundred	hundred	NUM
admet-193	12	28	publications	publication	NOUN
admet-193	12	29	(	(	PUNCT
admet-193	12	30	e.g.	e.g.	ADV
admet-193	12	31	,	,	PUNCT
admet-193	12	32	huuskonen	huuskonen	PROPN
admet-193	12	33	et	et	PROPN
admet-193	12	34	al	al	PROPN
admet-193	12	35	.	.	PUNCT
admet-193	13	1	[	[	X
admet-193	13	2	1,2	1,2	NUM
admet-193	13	3	]	]	PUNCT
admet-193	13	4	;	;	PUNCT
admet-193	13	5	abraham	abraham	PROPN
admet-193	13	6	and	and	CCONJ
admet-193	13	7	le	le	X
admet-193	14	1	[	[	X
admet-193	14	2	3	3	NUM
admet-193	14	3	]	]	PUNCT
admet-193	14	4	;	;	PUNCT
admet-193	14	5	jorgensen	jorgensen	PROPN
admet-193	14	6	and	and	CCONJ
admet-193	14	7	duffy	duffy	PROPN
admet-193	14	8	[	[	X
admet-193	14	9	4,5	4,5	NUM
admet-193	14	10	]	]	PUNCT
admet-193	14	11	;	;	PUNCT
admet-193	14	12	bergström	bergström	NOUN
admet-193	14	13	et	et	PROPN
admet-193	14	14	al	al	PROPN
admet-193	14	15	.	.	PUNCT
admet-193	15	1	[	[	X
admet-193	15	2	6	6	NUM
admet-193	15	3	]	]	PUNCT
admet-193	15	4	;	;	PUNCT
admet-193	15	5	hou	hou	PROPN
admet-193	15	6	et	et	PROPN
admet-193	15	7	al	al	PROPN
admet-193	15	8	.	.	PUNCT
admet-193	16	1	[	[	X
admet-193	16	2	7	7	NUM
admet-193	16	3	]	]	PUNCT
admet-193	16	4	;	;	PUNCT
admet-193	16	5	delaney	delaney	PROPN
admet-193	16	6	[	[	X
admet-193	16	7	8	8	NUM
admet-193	16	8	]	]	PUNCT
admet-193	16	9	;	;	PUNCT
admet-193	16	10	dearden	dearden	X
admet-193	17	1	[	[	X
admet-193	17	2	9	9	NUM
admet-193	17	3	]	]	PUNCT
admet-193	17	4	;	;	PUNCT
admet-193	17	5	balakin	balakin	PROPN
admet-193	17	6	et	et	PROPN
admet-193	17	7	al	al	PROPN
admet-193	17	8	.	.	PUNCT
admet-193	18	1	[	[	X
admet-193	18	2	10	10	NUM
admet-193	18	3	]	]	X
admet-193	18	4	;	;	PUNCT
admet-193	18	5	taskinen	taskinen	NOUN
admet-193	18	6	and	and	CCONJ
admet-193	18	7	norinder	norinder	NOUN
admet-193	18	8	[	[	X
admet-193	18	9	11	11	NUM
admet-193	18	10	]	]	PUNCT
admet-193	18	11	;	;	PUNCT
admet-193	18	12	jain	jain	NOUN
admet-193	18	13	and	and	CCONJ
admet-193	18	14	yalkowsky	yalkowsky	ADJ
admet-193	18	15	[	[	X
admet-193	18	16	12	12	NUM
admet-193	18	17	]	]	X
admet-193	18	18	;	;	PUNCT
admet-193	18	19	shayanfar	shayanfar	ADJ
admet-193	18	20	and	and	CCONJ
admet-193	18	21	jouyban	jouyban	ADJ
admet-193	18	22	[	[	X
admet-193	18	23	13	13	NUM
admet-193	18	24	]	]	PUNCT
admet-193	18	25	;	;	PUNCT
admet-193	18	26	wang	wang	PROPN
admet-193	18	27	and	and	CCONJ
admet-193	18	28	hou	hou	PROPN
admet-193	19	1	[	[	X
admet-193	19	2	14	14	NUM
admet-193	19	3	]	]	X
admet-193	19	4	;	;	PUNCT
admet-193	19	5	elder	elder	NOUN
admet-193	19	6	and	and	CCONJ
admet-193	19	7	holm	holm	PROPN
admet-193	19	8	[	[	X
admet-193	19	9	15	15	NUM
admet-193	19	10	]	]	PUNCT
admet-193	19	11	;	;	PUNCT
admet-193	19	12	mcdonagh	mcdonagh	PROPN
admet-193	19	13	et	et	PROPN
admet-193	19	14	al	al	PROPN
admet-193	19	15	.	.	PUNCT
admet-193	20	1	[	[	X
admet-193	20	2	16	16	NUM
admet-193	20	3	]	]	PUNCT
admet-193	20	4	)	)	PUNCT
admet-193	20	5	.	.	PUNCT
admet-193	21	1	the	the	DET
admet-193	21	2	typical	typical	ADJ
admet-193	21	3	errors	error	NOUN
admet-193	21	4	in	in	ADP
admet-193	21	5	drug	drug	NOUN
admet-193	21	6	solubility	solubility	NOUN
admet-193	21	7	prediction	prediction	NOUN
admet-193	21	8	are	be	AUX
admet-193	21	9	0.7	0.7	NUM
admet-193	21	10	–	–	PUNCT
admet-193	21	11	1.0	1.0	NUM
admet-193	21	12	log	log	NOUN
admet-193	21	13	unit	unit	NOUN
admet-193	21	14	,	,	PUNCT
admet-193	21	15	and	and	CCONJ
admet-193	21	16	for	for	ADP
admet-193	21	17	low	low	ADJ
admet-193	21	18	-	-	PUNCT
admet-193	21	19	soluble	soluble	ADJ
admet-193	21	20	compounds	compound	NOUN
admet-193	21	21	,	,	PUNCT
admet-193	21	22	errors	error	NOUN
admet-193	21	23	are	be	AUX
admet-193	21	24	considerably	considerably	ADV
admet-193	21	25	greater	great	ADJ
admet-193	21	26	than	than	ADP
admet-193	21	27	a	a	DET
admet-193	21	28	log	log	NOUN
admet-193	21	29	unit	unit	NOUN
admet-193	21	30	(	(	PUNCT
admet-193	21	31	jorgensen	jorgensen	PROPN
admet-193	21	32	and	and	CCONJ
admet-193	21	33	duffy	duffy	PROPN
admet-193	22	1	[	[	X
admet-193	22	2	5	5	NUM
admet-193	22	3	]	]	PUNCT
admet-193	22	4	;	;	PUNCT
admet-193	22	5	palmer	palmer	PROPN
admet-193	22	6	and	and	CCONJ
admet-193	22	7	mitchell	mitchell	PROPN
admet-193	23	1	[	[	X
admet-193	23	2	17	17	NUM
admet-193	23	3	]	]	PUNCT
admet-193	23	4	)	)	PUNCT
admet-193	23	5	.	.	PUNCT
admet-193	24	1	according	accord	VERB
admet-193	24	2	to	to	ADP
admet-193	24	3	faller	faller	NOUN
admet-193	24	4	and	and	CCONJ
admet-193	24	5	ertl	ertl	PROPN
admet-193	24	6	[	[	X
admet-193	24	7	18	18	NUM
admet-193	24	8	]	]	PUNCT
admet-193	24	9	,	,	PUNCT
admet-193	24	10	whose	whose	DET
admet-193	24	11	sentiment	sentiment	NOUN
admet-193	24	12	may	may	AUX
admet-193	24	13	be	be	AUX
admet-193	24	14	broadly	broadly	ADV
admet-193	24	15	shared	share	VERB
admet-193	24	16	,	,	PUNCT
admet-193	24	17	“	"	PUNCT
admet-193	24	18	no	no	DET
admet-193	24	19	really	really	ADV
admet-193	24	20	satisfactory	satisfactory	ADJ
admet-193	24	21	approach	approach	NOUN
admet-193	24	22	to	to	ADP
admet-193	24	23	(	(	PUNCT
admet-193	24	24	drug	drug	NOUN
admet-193	24	25	)	)	PUNCT
admet-193	24	26	solubility	solubility	NOUN
admet-193	24	27	prediction	prediction	NOUN
admet-193	24	28	is	be	AUX
admet-193	24	29	available	available	ADJ
admet-193	24	30	yet	yet	ADV
admet-193	24	31	,	,	PUNCT
admet-193	24	32	”	"	PUNCT
admet-193	24	33	in	in	ADP
admet-193	24	34	spite	spite	NOUN
admet-193	24	35	of	of	ADP
admet-193	24	36	the	the	DET
admet-193	24	37	large	large	ADJ
admet-193	24	38	number	number	NOUN
admet-193	24	39	of	of	ADP
admet-193	24	40	prediction	prediction	NOUN
admet-193	24	41	studies	study	NOUN
admet-193	24	42	.	.	PUNCT
admet-193	25	1	two	two	NUM
admet-193	25	2	large	large	ADJ
admet-193	25	3	aqueous	aqueous	ADJ
admet-193	25	4	solubility	solubility	NOUN
admet-193	25	5	databases	database	NOUN
admet-193	25	6	have	have	AUX
admet-193	25	7	been	be	AUX
admet-193	25	8	the	the	DET
admet-193	25	9	sources	source	NOUN
admet-193	25	10	for	for	ADP
admet-193	25	11	many	many	ADJ
admet-193	25	12	of	of	ADP
admet-193	25	13	the	the	PRON
admet-193	25	14	in	in	ADP
admet-193	25	15	silico	silico	NOUN
admet-193	25	16	studies	study	NOUN
admet-193	25	17	.	.	PUNCT
admet-193	26	1	first	first	ADV
admet-193	26	2	,	,	PUNCT
admet-193	26	3	the	the	DET
admet-193	26	4	1608	1608	NUM
admet-193	26	5	-	-	PUNCT
admet-193	26	6	page	page	NOUN
admet-193	26	7	handbook	handbook	NOUN
admet-193	26	8	of	of	ADP
admet-193	26	9	aqueous	aqueous	ADJ
admet-193	26	10	solubility	solubility	NOUN
admet-193	26	11	data	datum	NOUN
admet-193	26	12	,	,	PUNCT
admet-193	26	13	second	second	ADJ
admet-193	26	14	edition	edition	NOUN
admet-193	26	15	(	(	PUNCT
admet-193	26	16	yalkowsky	yalkowsky	PROPN
admet-193	26	17	et	et	PROPN
admet-193	26	18	al	al	PROPN
admet-193	26	19	.	.	PUNCT
admet-193	27	1	[	[	X
admet-193	27	2	19	19	NUM
admet-193	27	3	]	]	PUNCT
admet-193	27	4	)	)	PUNCT
admet-193	27	5	contains	contain	VERB
admet-193	27	6	over	over	ADP
admet-193	27	7	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-193	27	8	mailto:alex@in-adme.com	mailto:alex@in-adme.com	PROPN
admet-193	27	9	admet	admet	PROPN
admet-193	27	10	&	&	CCONJ
admet-193	27	11	dmpk	dmpk	PROPN
admet-193	27	12	3(2	3(2	NUM
admet-193	27	13	)	)	PUNCT
admet-193	27	14	(	(	PUNCT
admet-193	27	15	2015	2015	NUM
admet-193	27	16	)	)	PUNCT
admet-193	27	17	84	84	NUM
admet-193	27	18	-	-	SYM
admet-193	27	19	109	109	NUM
admet-193	27	20	equilibrium	equilibrium	NOUN
admet-193	27	21	solubility	solubility	NOUN
admet-193	27	22	measurements	measurement	NOUN
admet-193	27	23	improvements	improvement	NOUN
admet-193	27	24	doi	doi	NOUN
admet-193	27	25	:	:	PUNCT
admet-193	27	26	10.5599	10.5599	NUM
admet-193	27	27	/	/	SYM
admet-193	27	28	admet.3.2.193	admet.3.2.193	X
admet-193	27	29	85	85	NUM
admet-193	27	30	18,000	18,000	NUM
admet-193	27	31	solubility	solubility	NOUN
admet-193	27	32	values	value	NOUN
admet-193	27	33	covering	cover	VERB
admet-193	27	34	4661	4661	NUM
admet-193	27	35	molecules	molecule	NOUN
admet-193	27	36	,	,	PUNCT
admet-193	27	37	collected	collect	VERB
admet-193	27	38	from	from	ADP
admet-193	27	39	many	many	ADJ
admet-193	27	40	chemical	chemical	ADJ
admet-193	27	41	classes	class	NOUN
admet-193	27	42	,	,	PUNCT
admet-193	27	43	including	include	VERB
admet-193	27	44	pharmaceuticals	pharmaceutical	NOUN
admet-193	27	45	.	.	PUNCT
admet-193	28	1	second	second	ADJ
admet-193	28	2	,	,	PUNCT
admet-193	28	3	the	the	DET
admet-193	28	4	physprop	physprop	NOUN
admet-193	28	5	database	database	NOUN
admet-193	28	6	(	(	PUNCT
admet-193	28	7	howard	howard	PROPN
admet-193	28	8	and	and	CCONJ
admet-193	28	9	meylan	meylan	PROPN
admet-193	28	10	[	[	X
admet-193	28	11	20,21	20,21	NUM
admet-193	28	12	]	]	PUNCT
admet-193	28	13	)	)	PUNCT
admet-193	28	14	from	from	ADP
admet-193	28	15	syracuse	syracuse	PROPN
admet-193	28	16	research	research	PROPN
admet-193	28	17	corp	corp	PROPN
admet-193	28	18	.	.	PROPN
admet-193	28	19	(	(	PUNCT
admet-193	28	20	http://www.srcinc.com/	http://www.srcinc.com/	NOUN
admet-193	28	21	)	)	PUNCT
admet-193	28	22	had	have	AUX
admet-193	28	23	accumulated	accumulate	VERB
admet-193	28	24	over	over	ADP
admet-193	28	25	6000	6000	NUM
admet-193	28	26	measured	measure	VERB
admet-193	28	27	solubility	solubility	NOUN
admet-193	28	28	values	value	NOUN
admet-193	28	29	,	,	PUNCT
admet-193	28	30	with	with	ADP
admet-193	28	31	substantial	substantial	ADJ
admet-193	28	32	coverage	coverage	NOUN
admet-193	28	33	of	of	ADP
admet-193	28	34	agrochemicals	agrochemical	NOUN
admet-193	28	35	and	and	CCONJ
admet-193	28	36	potential	potential	ADJ
admet-193	28	37	environmental	environmental	ADJ
admet-193	28	38	pollutants	pollutant	NOUN
admet-193	28	39	.	.	PUNCT
admet-193	29	1	in	in	ADP
admet-193	29	2	the	the	DET
admet-193	29	3	two	two	NUM
admet-193	29	4	curated	curate	VERB
admet-193	29	5	compilations	compilation	NOUN
admet-193	29	6	,	,	PUNCT
admet-193	29	7	the	the	DET
admet-193	29	8	ph	ph	NOUN
admet-193	29	9	of	of	ADP
admet-193	29	10	saturated	saturate	VERB
admet-193	29	11	solutions	solution	NOUN
admet-193	29	12	had	have	AUX
admet-193	29	13	not	not	PART
admet-193	29	14	been	be	AUX
admet-193	29	15	reported	report	VERB
admet-193	29	16	for	for	ADP
admet-193	29	17	most	most	ADJ
admet-193	29	18	of	of	ADP
admet-193	29	19	the	the	DET
admet-193	29	20	ionizable	ionizable	ADJ
admet-193	29	21	compounds	compound	NOUN
admet-193	29	22	.	.	PUNCT
admet-193	30	1	in	in	ADP
admet-193	30	2	addition	addition	NOUN
admet-193	30	3	,	,	PUNCT
admet-193	30	4	smaller	small	ADJ
admet-193	30	5	databases	database	NOUN
admet-193	30	6	of	of	ADP
admet-193	30	7	crystalline	crystalline	ADJ
admet-193	30	8	drug	drug	NOUN
admet-193	30	9	-	-	PUNCT
admet-193	30	10	like	like	ADJ
admet-193	30	11	molecules	molecule	NOUN
admet-193	30	12	have	have	AUX
admet-193	30	13	been	be	AUX
admet-193	30	14	published	publish	VERB
admet-193	30	15	(	(	PUNCT
admet-193	30	16	analytical	analytical	ADJ
admet-193	30	17	profiles	profile	NOUN
admet-193	30	18	of	of	ADP
admet-193	30	19	drug	drug	NOUN
admet-193	30	20	substances	substance	NOUN
admet-193	31	1	[	[	X
admet-193	31	2	22	22	NUM
admet-193	31	3	]	]	PUNCT
admet-193	31	4	,	,	PUNCT
admet-193	31	5	mcfarland	mcfarland	PROPN
admet-193	31	6	et	et	PROPN
admet-193	31	7	al	al	PROPN
admet-193	31	8	.	.	PUNCT
admet-193	32	1	[	[	X
admet-193	32	2	23	23	NUM
admet-193	32	3	]	]	PUNCT
admet-193	32	4	;	;	PUNCT
admet-193	32	5	rytting	rytte	VERB
admet-193	32	6	et	et	PROPN
admet-193	32	7	al	al	PROPN
admet-193	32	8	.	.	PUNCT
admet-193	33	1	[	[	X
admet-193	33	2	24	24	NUM
admet-193	33	3	]	]	PUNCT
admet-193	33	4	;	;	PUNCT
admet-193	33	5	bergström	bergström	NOUN
admet-193	33	6	et	et	PROPN
admet-193	33	7	al	al	PROPN
admet-193	33	8	.	.	PUNCT
admet-193	34	1	[	[	X
admet-193	34	2	25	25	NUM
admet-193	34	3	]	]	X
admet-193	34	4	;	;	PUNCT
admet-193	34	5	faller	faller	NOUN
admet-193	34	6	and	and	CCONJ
admet-193	34	7	ertl	ertl	PROPN
admet-193	35	1	[	[	X
admet-193	35	2	18	18	NUM
admet-193	35	3	]	]	X
admet-193	35	4	;	;	PUNCT
admet-193	35	5	llinàs	llinàs	PROPN
admet-193	35	6	et	et	PROPN
admet-193	35	7	al	al	PROPN
admet-193	35	8	.	.	PUNCT
admet-193	36	1	[	[	X
admet-193	36	2	26	26	NUM
admet-193	36	3	]	]	X
admet-193	36	4	;	;	PUNCT
admet-193	36	5	hopfinger	hopfinger	PROPN
admet-193	36	6	et	et	PROPN
admet-193	36	7	al	al	PROPN
admet-193	36	8	.	.	PUNCT
admet-193	37	1	[	[	X
admet-193	37	2	27	27	NUM
admet-193	37	3	]	]	NUM
admet-193	37	4	)	)	PUNCT
admet-193	37	5	.	.	PUNCT
admet-193	38	1	these	these	DET
admet-193	38	2	smaller	small	ADJ
admet-193	38	3	databases	database	NOUN
admet-193	38	4	consist	consist	VERB
admet-193	38	5	largely	largely	ADV
admet-193	38	6	of	of	ADP
admet-193	38	7	intrinsic	intrinsic	ADJ
admet-193	38	8	solubility	solubility	NOUN
admet-193	38	9	values	value	NOUN
admet-193	38	10	,	,	PUNCT
admet-193	38	11	s0	s0	PROPN
admet-193	38	12	–	–	PUNCT
admet-193	38	13	i.e.	i.e.	X
admet-193	38	14	,	,	PUNCT
admet-193	38	15	the	the	DET
admet-193	38	16	solubility	solubility	NOUN
admet-193	38	17	of	of	ADP
admet-193	38	18	the	the	DET
admet-193	38	19	neutral	neutral	ADJ
admet-193	38	20	species	specie	NOUN
admet-193	38	21	.	.	PUNCT
admet-193	39	1	the	the	DET
admet-193	39	2	most	most	ADV
admet-193	39	3	cited	cite	VERB
admet-193	39	4	challenge	challenge	NOUN
admet-193	39	5	to	to	ADP
admet-193	39	6	good	good	ADJ
admet-193	39	7	prediction	prediction	NOUN
admet-193	39	8	has	have	AUX
admet-193	39	9	been	be	AUX
admet-193	39	10	the	the	DET
admet-193	39	11	difficulty	difficulty	NOUN
admet-193	39	12	to	to	PART
admet-193	39	13	access	access	VERB
admet-193	39	14	enough	enough	ADJ
admet-193	39	15	high	high	ADJ
admet-193	39	16	-	-	PUNCT
admet-193	39	17	quality	quality	NOUN
admet-193	39	18	,	,	PUNCT
admet-193	39	19	drugrelevant	drugrelevant	NOUN
admet-193	39	20	,	,	PUNCT
admet-193	39	21	and	and	CCONJ
admet-193	39	22	sufficiently	sufficiently	ADV
admet-193	39	23	-	-	PUNCT
admet-193	39	24	diverse	diverse	ADJ
admet-193	39	25	solubility	solubility	NOUN
admet-193	39	26	data	datum	NOUN
admet-193	39	27	that	that	PRON
admet-193	39	28	adequately	adequately	ADV
admet-193	39	29	cover	cover	VERB
admet-193	39	30	the	the	DET
admet-193	39	31	chemical	chemical	ADJ
admet-193	39	32	space	space	NOUN
admet-193	39	33	of	of	ADP
admet-193	39	34	drugs	drug	NOUN
admet-193	39	35	and	and	CCONJ
admet-193	39	36	hopefully	hopefully	ADV
admet-193	39	37	that	that	PRON
admet-193	39	38	of	of	ADP
admet-193	39	39	research	research	NOUN
admet-193	39	40	compounds	compound	NOUN
admet-193	39	41	.	.	PUNCT
admet-193	40	1	in	in	ADP
admet-193	40	2	this	this	DET
admet-193	40	3	context	context	NOUN
admet-193	40	4	,	,	PUNCT
admet-193	40	5	the	the	DET
admet-193	40	6	focus	focus	NOUN
admet-193	40	7	on	on	ADP
admet-193	40	8	drug	drug	NOUN
admet-193	40	9	molecules	molecule	NOUN
admet-193	40	10	is	be	AUX
admet-193	40	11	important	important	ADJ
admet-193	40	12	,	,	PUNCT
admet-193	40	13	since	since	SCONJ
admet-193	40	14	it	it	PRON
admet-193	40	15	is	be	AUX
admet-193	40	16	consistently	consistently	ADV
admet-193	40	17	shown	show	VERB
admet-193	40	18	that	that	SCONJ
admet-193	40	19	the	the	DET
admet-193	40	20	best	good	ADJ
admet-193	40	21	prediction	prediction	NOUN
admet-193	40	22	models	model	NOUN
admet-193	40	23	are	be	AUX
admet-193	40	24	devised	devise	VERB
admet-193	40	25	from	from	ADP
admet-193	40	26	training	training	NOUN
admet-193	40	27	sets	set	NOUN
admet-193	40	28	most	most	ADV
admet-193	40	29	similar	similar	ADJ
admet-193	40	30	to	to	ADP
admet-193	40	31	the	the	DET
admet-193	40	32	test	test	NOUN
admet-193	40	33	sets	set	NOUN
admet-193	40	34	(	(	PUNCT
admet-193	40	35	walters	walter	NOUN
admet-193	40	36	[	[	X
admet-193	40	37	28	28	NUM
admet-193	40	38	]	]	NUM
admet-193	40	39	)	)	PUNCT
admet-193	40	40	.	.	PUNCT
admet-193	41	1	however	however	ADV
admet-193	41	2	,	,	PUNCT
admet-193	41	3	palmer	palmer	PROPN
admet-193	41	4	and	and	CCONJ
admet-193	41	5	mitchell	mitchell	PROPN
admet-193	41	6	[	[	X
admet-193	41	7	17	17	NUM
admet-193	41	8	]	]	PUNCT
admet-193	41	9	posed	pose	VERB
admet-193	41	10	a	a	DET
admet-193	41	11	contrarian	contrarian	ADJ
admet-193	41	12	view	view	NOUN
admet-193	41	13	that	that	SCONJ
admet-193	41	14	the	the	DET
admet-193	41	15	challenge	challenge	NOUN
admet-193	41	16	to	to	ADP
admet-193	41	17	good	good	ADJ
admet-193	41	18	prediction	prediction	NOUN
admet-193	41	19	might	might	AUX
admet-193	41	20	rest	rest	VERB
admet-193	41	21	in	in	ADP
admet-193	41	22	the	the	DET
admet-193	41	23	deficiency	deficiency	NOUN
admet-193	41	24	of	of	ADP
admet-193	41	25	current	current	ADJ
admet-193	41	26	qspr	qspr	NOUN
admet-193	41	27	methods	method	NOUN
admet-193	41	28	.	.	PUNCT
admet-193	42	1	measuring	measure	VERB
admet-193	42	2	high	high	ADJ
admet-193	42	3	quality	quality	NOUN
admet-193	42	4	data	datum	NOUN
admet-193	42	5	is	be	AUX
admet-193	42	6	expensive	expensive	ADJ
admet-193	42	7	and	and	CCONJ
admet-193	42	8	analytical	analytical	ADJ
admet-193	42	9	-	-	PUNCT
admet-193	42	10	resource	resource	NOUN
admet-193	42	11	consuming	consuming	NOUN
admet-193	42	12	.	.	PUNCT
admet-193	43	1	even	even	ADV
admet-193	43	2	with	with	ADP
admet-193	43	3	great	great	ADJ
admet-193	43	4	costing	costing	NOUN
admet-193	43	5	,	,	PUNCT
admet-193	43	6	quality	quality	NOUN
admet-193	43	7	is	be	AUX
admet-193	43	8	not	not	PART
admet-193	43	9	ensured	ensure	VERB
admet-193	43	10	when	when	SCONJ
admet-193	43	11	results	result	NOUN
admet-193	43	12	are	be	AUX
admet-193	43	13	determined	determine	VERB
admet-193	43	14	from	from	ADP
admet-193	43	15	poorly	poorly	ADV
admet-193	43	16	-	-	PUNCT
admet-193	43	17	designed	design	VERB
admet-193	43	18	assays	assay	NOUN
admet-193	43	19	.	.	PUNCT
admet-193	44	1	selecting	select	VERB
admet-193	44	2	training	training	NOUN
admet-193	44	3	set	set	VERB
admet-193	44	4	molecules	molecule	NOUN
admet-193	44	5	which	which	PRON
admet-193	44	6	are	be	AUX
admet-193	44	7	ionizable	ionizable	ADJ
admet-193	44	8	,	,	PUNCT
admet-193	44	9	but	but	CCONJ
admet-193	44	10	ignoring	ignore	VERB
admet-193	44	11	the	the	DET
admet-193	44	12	effect	effect	NOUN
admet-193	44	13	of	of	ADP
admet-193	44	14	ph	ph	NOUN
admet-193	44	15	,	,	PUNCT
admet-193	44	16	can	can	AUX
admet-193	44	17	mitigate	mitigate	VERB
admet-193	44	18	accurate	accurate	ADJ
admet-193	44	19	prediction	prediction	NOUN
admet-193	44	20	.	.	PUNCT
admet-193	45	1	drawing	draw	VERB
admet-193	45	2	on	on	ADP
admet-193	45	3	data	datum	NOUN
admet-193	45	4	from	from	ADP
admet-193	45	5	a	a	DET
admet-193	45	6	range	range	NOUN
admet-193	45	7	of	of	ADP
admet-193	45	8	temperatures	temperature	NOUN
admet-193	45	9	without	without	ADP
admet-193	45	10	adjustments	adjustment	NOUN
admet-193	45	11	also	also	ADV
admet-193	45	12	can	can	AUX
admet-193	45	13	be	be	AUX
admet-193	45	14	problematic	problematic	ADJ
admet-193	45	15	.	.	PUNCT
admet-193	46	1	there	there	PRON
admet-193	46	2	are	be	VERB
admet-193	46	3	other	other	ADJ
admet-193	46	4	factors	factor	NOUN
admet-193	46	5	that	that	PRON
admet-193	46	6	affect	affect	VERB
admet-193	46	7	data	datum	NOUN
admet-193	46	8	quality	quality	NOUN
admet-193	46	9	.	.	PUNCT
admet-193	47	1	to	to	PART
admet-193	47	2	address	address	VERB
admet-193	47	3	many	many	ADJ
admet-193	47	4	of	of	ADP
admet-193	47	5	the	the	DET
admet-193	47	6	above	above	ADJ
admet-193	47	7	concerns	concern	NOUN
admet-193	47	8	,	,	PUNCT
admet-193	47	9	this	this	DET
admet-193	47	10	review	review	NOUN
admet-193	47	11	draws	draw	VERB
admet-193	47	12	on	on	ADP
admet-193	47	13	our	our	PRON
admet-193	47	14	past	past	ADJ
admet-193	47	15	experiences	experience	NOUN
admet-193	47	16	and	and	CCONJ
admet-193	47	17	also	also	ADV
admet-193	47	18	on	on	ADP
admet-193	47	19	the	the	DET
admet-193	47	20	examination	examination	NOUN
admet-193	47	21	of	of	ADP
admet-193	47	22	over	over	ADP
admet-193	47	23	800	800	NUM
admet-193	47	24	publications	publication	NOUN
admet-193	47	25	to	to	PART
admet-193	47	26	suggest	suggest	VERB
admet-193	47	27	ways	way	NOUN
admet-193	47	28	(	(	PUNCT
admet-193	47	29	a	a	NOUN
admet-193	47	30	)	)	PUNCT
admet-193	47	31	to	to	PART
admet-193	47	32	improve	improve	VERB
admet-193	47	33	the	the	DET
admet-193	47	34	quality	quality	NOUN
admet-193	47	35	of	of	ADP
admet-193	47	36	future	future	ADJ
admet-193	47	37	measurement	measurement	NOUN
admet-193	47	38	of	of	ADP
admet-193	47	39	equilibrium	equilibrium	NOUN
admet-193	47	40	solubility	solubility	NOUN
admet-193	47	41	and	and	CCONJ
admet-193	47	42	(	(	PUNCT
admet-193	47	43	b	b	NOUN
admet-193	47	44	)	)	PUNCT
admet-193	47	45	to	to	PART
admet-193	47	46	normalize	normalize	VERB
admet-193	47	47	existing	exist	VERB
admet-193	47	48	data	datum	NOUN
admet-193	47	49	for	for	ADP
admet-193	47	50	ph	ph	ADJ
admet-193	47	51	and	and	CCONJ
admet-193	47	52	temperature	temperature	NOUN
admet-193	47	53	effects	effect	NOUN
admet-193	47	54	to	to	PART
admet-193	47	55	extract	extract	VERB
admet-193	47	56	intrinsic	intrinsic	ADJ
admet-193	47	57	solubility	solubility	NOUN
admet-193	47	58	values	value	NOUN
admet-193	47	59	with	with	ADP
admet-193	47	60	improved	improved	ADJ
admet-193	47	61	accuracy	accuracy	NOUN
admet-193	47	62	.	.	PUNCT
admet-193	48	1	we	we	PRON
admet-193	48	2	focus	focus	VERB
admet-193	48	3	on	on	ADP
admet-193	48	4	the	the	DET
admet-193	48	5	shake	shake	NOUN
admet-193	48	6	-	-	PUNCT
admet-193	48	7	flask	flask	NOUN
admet-193	48	8	solubility	solubility	NOUN
admet-193	48	9	measurement	measurement	NOUN
admet-193	48	10	as	as	ADP
admet-193	48	11	a	a	DET
admet-193	48	12	function	function	NOUN
admet-193	48	13	of	of	ADP
admet-193	48	14	ph	ph	NOUN
admet-193	48	15	which	which	PRON
admet-193	48	16	is	be	AUX
admet-193	48	17	still	still	ADV
admet-193	48	18	the	the	DET
admet-193	48	19	“	"	PUNCT
admet-193	48	20	gold	gold	ADJ
admet-193	48	21	standard	standard	NOUN
admet-193	48	22	”	"	PUNCT
admet-193	48	23	methodology	methodology	NOUN
admet-193	48	24	in	in	ADP
admet-193	48	25	the	the	DET
admet-193	48	26	minds	mind	NOUN
admet-193	48	27	of	of	ADP
admet-193	48	28	most	most	ADJ
admet-193	48	29	experimentalists	experimentalist	NOUN
admet-193	48	30	.	.	PUNCT
admet-193	49	1	also	also	ADV
admet-193	49	2	,	,	PUNCT
admet-193	49	3	two	two	NUM
admet-193	49	4	potentiometric	potentiometric	ADJ
admet-193	49	5	methods	method	NOUN
admet-193	49	6	are	be	AUX
admet-193	49	7	considered	consider	VERB
admet-193	49	8	.	.	PUNCT
admet-193	50	1	the	the	DET
admet-193	50	2	characterization	characterization	NOUN
admet-193	50	3	of	of	ADP
admet-193	50	4	solid	solid	ADJ
admet-193	50	5	forms	form	NOUN
admet-193	50	6	(	(	PUNCT
admet-193	50	7	crystalline	crystalline	NOUN
admet-193	50	8	,	,	PUNCT
admet-193	50	9	amorphous	amorphous	ADJ
admet-193	50	10	,	,	PUNCT
admet-193	50	11	nanoparticle	nanoparticle	NOUN
admet-193	50	12	,	,	PUNCT
admet-193	50	13	etc	etc	X
admet-193	50	14	.	.	X
admet-193	50	15	)	)	PUNCT
admet-193	50	16	and	and	CCONJ
admet-193	50	17	their	their	PRON
admet-193	50	18	impact	impact	NOUN
admet-193	50	19	on	on	ADP
admet-193	50	20	the	the	DET
admet-193	50	21	measured	measured	ADJ
admet-193	50	22	solubility	solubility	NOUN
admet-193	50	23	are	be	AUX
admet-193	50	24	beyond	beyond	ADP
admet-193	50	25	the	the	DET
admet-193	50	26	scope	scope	NOUN
admet-193	50	27	of	of	ADP
admet-193	50	28	this	this	DET
admet-193	50	29	review	review	NOUN
admet-193	50	30	,	,	PUNCT
admet-193	50	31	although	although	SCONJ
admet-193	50	32	some	some	DET
admet-193	50	33	aspects	aspect	NOUN
admet-193	50	34	(	(	PUNCT
admet-193	50	35	i.e.	i.e.	X
admet-193	50	36	,	,	PUNCT
admet-193	50	37	solvate	solvate	NOUN
admet-193	50	38	,	,	PUNCT
admet-193	50	39	polymorph	polymorph	NOUN
admet-193	50	40	,	,	PUNCT
admet-193	50	41	racemate	racemate	ADJ
admet-193	50	42	effects	effect	NOUN
admet-193	50	43	)	)	PUNCT
admet-193	50	44	are	be	AUX
admet-193	50	45	noted	note	VERB
admet-193	50	46	.	.	PUNCT
admet-193	51	1	in	in	ADP
admet-193	51	2	part	part	NOUN
admet-193	51	3	,	,	PUNCT
admet-193	51	4	this	this	DET
admet-193	51	5	review	review	NOUN
admet-193	51	6	serves	serve	VERB
admet-193	51	7	as	as	ADP
admet-193	51	8	background	background	NOUN
admet-193	51	9	preparation	preparation	NOUN
admet-193	51	10	for	for	ADP
admet-193	51	11	the	the	DET
admet-193	51	12	“	"	PUNCT
admet-193	51	13	panel	panel	NOUN
admet-193	51	14	of	of	ADP
admet-193	51	15	experts	expert	NOUN
admet-193	51	16	”	"	PUNCT
admet-193	51	17	solubility	solubility	NOUN
admet-193	51	18	session	session	NOUN
admet-193	51	19	at	at	ADP
admet-193	51	20	the	the	DET
admet-193	51	21	4th	4th	ADJ
admet-193	51	22	world	world	NOUN
admet-193	51	23	conference	conference	NOUN
admet-193	51	24	on	on	ADP
admet-193	51	25	physico	physico	NOUN
admet-193	51	26	chemical	chemical	NOUN
admet-193	51	27	methods	method	NOUN
admet-193	51	28	in	in	ADP
admet-193	51	29	drug	drug	NOUN
admet-193	51	30	discovery	discovery	NOUN
admet-193	51	31	and	and	CCONJ
admet-193	51	32	development	development	NOUN
admet-193	51	33	(	(	PUNCT
admet-193	51	34	pcmddd-4	pcmddd-4	NOUN
admet-193	51	35	)	)	PUNCT
admet-193	51	36	in	in	ADP
admet-193	51	37	croatia	croatia	PROPN
admet-193	51	38	,	,	PUNCT
admet-193	51	39	21	21	NUM
admet-193	51	40	-	-	SYM
admet-193	51	41	24	24	NUM
admet-193	51	42	september	september	PROPN
admet-193	51	43	2015	2015	NUM
admet-193	51	44	(	(	PUNCT
admet-193	51	45	http://www.iapchem.org/page.php?page_id=56	http://www.iapchem.org/page.php?page_id=56	NOUN
admet-193	51	46	)	)	PUNCT
admet-193	51	47	.	.	PUNCT
admet-193	52	1	methods	method	NOUN
admet-193	52	2	briefly	briefly	ADV
admet-193	52	3	stated	state	VERB
admet-193	52	4	,	,	PUNCT
admet-193	52	5	in	in	ADP
admet-193	52	6	the	the	DET
admet-193	52	7	course	course	NOUN
admet-193	52	8	of	of	ADP
admet-193	52	9	gathering	gather	VERB
admet-193	52	10	published	publish	VERB
admet-193	52	11	aqueous	aqueous	ADJ
admet-193	52	12	solubility	solubility	NOUN
admet-193	52	13	training	training	NOUN
admet-193	52	14	data	datum	NOUN
admet-193	52	15	,	,	PUNCT
admet-193	52	16	803	803	NUM
admet-193	52	17	publications	publication	NOUN
admet-193	52	18	have	have	AUX
admet-193	52	19	been	be	AUX
admet-193	52	20	examined	examine	VERB
admet-193	52	21	and	and	CCONJ
admet-193	52	22	a	a	DET
admet-193	52	23	largely	largely	ADV
admet-193	52	24	fresh	fresh	ADJ
admet-193	52	25	intrinsic	intrinsic	ADJ
admet-193	52	26	solubility	solubility	NOUN
admet-193	52	27	database	database	NOUN
admet-193	52	28	containing	contain	VERB
admet-193	52	29	4557	4557	NUM
admet-193	52	30	entries	entry	NOUN
admet-193	52	31	for	for	ADP
admet-193	52	32	2413	2413	NUM
admet-193	52	33	compounds	compound	NOUN
admet-193	52	34	has	have	AUX
admet-193	52	35	been	be	AUX
admet-193	52	36	assembled	assemble	VERB
admet-193	52	37	.	.	PUNCT
admet-193	53	1	in	in	ADP
admet-193	53	2	addition	addition	NOUN
admet-193	53	3	to	to	ADP
admet-193	53	4	this	this	PRON
admet-193	53	5	,	,	PUNCT
admet-193	53	6	666	666	NUM
admet-193	53	7	publications	publication	NOUN
admet-193	53	8	reporting	report	VERB
admet-193	53	9	pka	pka	PROPN
admet-193	53	10	values	value	NOUN
admet-193	53	11	have	have	AUX
admet-193	53	12	been	be	AUX
admet-193	53	13	processed	process	VERB
admet-193	53	14	,	,	PUNCT
admet-193	53	15	to	to	PART
admet-193	53	16	add	add	VERB
admet-193	53	17	to	to	ADP
admet-193	53	18	the	the	DET
admet-193	53	19	in	in	ADP
admet-193	53	20	-	-	PUNCT
admet-193	53	21	adme	adme	NOUN
admet-193	53	22	research	research	NOUN
admet-193	53	23	wiki	wiki	PROPN
admet-193	53	24	-	-	PUNCT
admet-193	53	25	pka	pka	NOUN
admet-193	53	26	database	database	NOUN
admet-193	53	27	,	,	PUNCT
admet-193	53	28	now	now	ADV
admet-193	53	29	consisting	consist	VERB
admet-193	53	30	of	of	ADP
admet-193	53	31	2651	2651	NUM
admet-193	53	32	qualified	qualified	ADJ
admet-193	53	33	entries	entry	NOUN
admet-193	53	34	(	(	PUNCT
admet-193	53	35	www.in-adme.com/wiki_pka.php	www.in-adme.com/wiki_pka.php	PROPN
admet-193	53	36	)	)	PUNCT
admet-193	53	37	.	.	PUNCT
admet-193	54	1	it	it	PRON
admet-193	54	2	has	have	AUX
admet-193	54	3	been	be	AUX
admet-193	54	4	nearly	nearly	ADV
admet-193	54	5	a	a	DET
admet-193	54	6	full	full	ADJ
admet-193	54	7	-	-	PUNCT
admet-193	54	8	time	time	NOUN
admet-193	54	9	project	project	NOUN
admet-193	54	10	at	at	ADP
admet-193	54	11	in	in	ADP
admet-193	54	12	-	-	PUNCT
admet-193	54	13	adme	adme	NOUN
admet-193	54	14	research	research	NOUN
admet-193	54	15	since	since	SCONJ
admet-193	54	16	2011	2011	NUM
admet-193	54	17	.	.	PUNCT
admet-193	55	1	the	the	DET
admet-193	55	2	collection	collection	NOUN
admet-193	55	3	of	of	ADP
admet-193	55	4	training	training	NOUN
admet-193	55	5	data	datum	NOUN
admet-193	55	6	is	be	AUX
admet-193	55	7	nearing	near	VERB
admet-193	55	8	a	a	DET
admet-193	55	9	state	state	NOUN
admet-193	55	10	suitable	suitable	ADJ
admet-193	55	11	to	to	PART
admet-193	55	12	support	support	VERB
admet-193	55	13	a	a	DET
admet-193	55	14	new	new	ADJ
admet-193	55	15	solubility	solubility	NOUN
admet-193	55	16	prediction	prediction	NOUN
admet-193	55	17	effort	effort	NOUN
admet-193	55	18	,	,	PUNCT
admet-193	55	19	which	which	PRON
admet-193	55	20	is	be	AUX
admet-193	55	21	planned	plan	VERB
admet-193	55	22	to	to	PART
admet-193	55	23	be	be	AUX
admet-193	55	24	the	the	DET
admet-193	55	25	subject	subject	NOUN
admet-193	55	26	of	of	ADP
admet-193	55	27	another	another	DET
admet-193	55	28	publication	publication	NOUN
admet-193	55	29	.	.	PUNCT
admet-193	56	1	we	we	PRON
admet-193	56	2	are	be	AUX
admet-193	56	3	energized	energize	VERB
admet-193	56	4	to	to	PART
admet-193	56	5	improve	improve	VERB
admet-193	56	6	the	the	DET
admet-193	56	7	accuracy	accuracy	NOUN
admet-193	56	8	of	of	ADP
admet-193	56	9	the	the	DET
admet-193	56	10	prediction	prediction	NOUN
admet-193	56	11	of	of	ADP
admet-193	56	12	intrinsic	intrinsic	ADJ
admet-193	56	13	solubility	solubility	NOUN
admet-193	56	14	from	from	ADP
admet-193	56	15	2d	2d	NUM
admet-193	56	16	structure	structure	NOUN
admet-193	56	17	,	,	PUNCT
admet-193	56	18	particularly	particularly	ADV
admet-193	56	19	of	of	ADP
admet-193	56	20	sparingly	sparingly	ADV
admet-193	56	21	-	-	PUNCT
admet-193	56	22	soluble	soluble	ADJ
admet-193	56	23	(	(	PUNCT
admet-193	56	24	or	or	CCONJ
admet-193	56	25	practically	practically	ADV
admet-193	56	26	-	-	PUNCT
admet-193	56	27	insoluble	insoluble	ADJ
admet-193	56	28	)	)	PUNCT
admet-193	56	29	ionizable	ionizable	ADJ
admet-193	56	30	drug	drug	NOUN
admet-193	56	31	-	-	PUNCT
admet-193	56	32	relevant	relevant	ADJ
admet-193	56	33	molecules	molecule	NOUN
admet-193	56	34	.	.	PUNCT
admet-193	57	1	preliminary	preliminary	ADJ
admet-193	57	2	random	random	ADJ
admet-193	57	3	forest	forest	NOUN
admet-193	57	4	regression	regression	NOUN
admet-193	57	5	modeling	modeling	NOUN
admet-193	57	6	(	(	PUNCT
admet-193	57	7	walters	walters	PROPN
admet-193	57	8	[	[	X
admet-193	57	9	28	28	NUM
admet-193	57	10	]	]	PUNCT
admet-193	57	11	)	)	PUNCT
admet-193	57	12	has	have	AUX
admet-193	57	13	been	be	AUX
admet-193	57	14	tried	try	VERB
admet-193	57	15	using	use	VERB
admet-193	57	16	the	the	DET
admet-193	57	17	193	193	NUM
admet-193	57	18	descriptors	descriptor	NOUN
admet-193	57	19	calculated	calculate	VERB
admet-193	57	20	by	by	ADP
admet-193	57	21	the	the	DET
admet-193	57	22	open	open	ADJ
admet-193	57	23	-	-	PUNCT
admet-193	57	24	source	source	NOUN
admet-193	57	25	chemoinformatics	chemoinformatic	NOUN
admet-193	57	26	and	and	CCONJ
admet-193	57	27	machine	machine	NOUN
admet-193	57	28	learning	learn	VERB
admet-193	57	29	http://www.srcinc.com/	http://www.srcinc.com/	NOUN
admet-193	57	30	http://www.iapchem.org/page.php?page_id=56	http://www.iapchem.org/page.php?page_id=56	NOUN
admet-193	57	31	avdeef	avdeef	NOUN
admet-193	57	32	admet	admet	PROPN
admet-193	57	33	&	&	CCONJ
admet-193	57	34	dmpk	dmpk	PROPN
admet-193	57	35	3(2	3(2	NUM
admet-193	57	36	)	)	PUNCT
admet-193	57	37	(	(	PUNCT
admet-193	57	38	2015	2015	NUM
admet-193	57	39	)	)	PUNCT
admet-193	57	40	84	84	NUM
admet-193	57	41	-	-	SYM
admet-193	57	42	109	109	NUM
admet-193	57	43	86	86	NUM
admet-193	57	44	rdkit	rdkit	ADJ
admet-193	57	45	library	library	NOUN
admet-193	57	46	of	of	ADP
admet-193	57	47	programs	program	NOUN
admet-193	57	48	(	(	PUNCT
admet-193	57	49	landrum	landrum	PROPN
admet-193	57	50	et	et	PROPN
admet-193	57	51	al	al	PROPN
admet-193	57	52	.	.	PUNCT
admet-193	58	1	[	[	X
admet-193	58	2	29	29	NUM
admet-193	58	3	]	]	PUNCT
admet-193	58	4	;	;	PUNCT
admet-193	58	5	http://rdkit.readthedocs.org/en/latest/	http://rdkit.readthedocs.org/en/latest/	PROPN
admet-193	58	6	)	)	PUNCT
admet-193	58	7	,	,	PUNCT
admet-193	58	8	combined	combine	VERB
admet-193	58	9	with	with	ADP
admet-193	58	10	the	the	DET
admet-193	58	11	abraham	abraham	PROPN
admet-193	58	12	five	five	NUM
admet-193	58	13	solvation	solvation	NOUN
admet-193	58	14	descriptors	descriptor	NOUN
admet-193	58	15	(	(	PUNCT
admet-193	58	16	abraham	abraham	PROPN
admet-193	58	17	et	et	PROPN
admet-193	58	18	al	al	PROPN
admet-193	58	19	.	.	PUNCT
admet-193	59	1	[	[	X
admet-193	59	2	30	30	NUM
admet-193	59	3	]	]	NUM
admet-193	59	4	)	)	PUNCT
admet-193	59	5	,	,	PUNCT
admet-193	59	6	and	and	CCONJ
admet-193	59	7	lang	lang	PROPN
admet-193	59	8	and	and	CCONJ
admet-193	59	9	bradley	bradley	PROPN
admet-193	60	1	[	[	X
admet-193	60	2	31	31	NUM
admet-193	60	3	]	]	PUNCT
admet-193	60	4	predicted	predict	VERB
admet-193	60	5	melting	melting	NOUN
admet-193	60	6	points	point	NOUN
admet-193	60	7	in	in	ADP
admet-193	60	8	the	the	DET
admet-193	60	9	qsardb	qsardb	NOUN
admet-193	60	10	open	open	ADJ
admet-193	60	11	repository	repository	NOUN
admet-193	60	12	of	of	ADP
admet-193	60	13	data	datum	NOUN
admet-193	60	14	and	and	CCONJ
admet-193	60	15	prediction	prediction	NOUN
admet-193	60	16	tools	tool	NOUN
admet-193	60	17	(	(	PUNCT
admet-193	60	18	http://qsardb.org/repository/handle/10967/104	http://qsardb.org/repository/handle/10967/104	NOUN
admet-193	60	19	)	)	PUNCT
admet-193	60	20	.	.	PUNCT
admet-193	61	1	the	the	DET
admet-193	61	2	most	most	ADV
admet-193	61	3	sensitive	sensitive	ADJ
admet-193	61	4	molecular	molecular	ADJ
admet-193	61	5	descriptors	descriptor	NOUN
admet-193	61	6	will	will	AUX
admet-193	61	7	be	be	AUX
admet-193	61	8	further	far	ADV
admet-193	61	9	tested	test	VERB
admet-193	61	10	in	in	ADP
admet-193	61	11	partial	partial	ADJ
admet-193	61	12	least	least	ADJ
admet-193	61	13	squares	square	NOUN
admet-193	61	14	models	model	NOUN
admet-193	61	15	,	,	PUNCT
admet-193	61	16	to	to	PART
admet-193	61	17	better	well	ADV
admet-193	61	18	understand	understand	VERB
admet-193	61	19	the	the	DET
admet-193	61	20	impact	impact	NOUN
admet-193	61	21	of	of	ADP
admet-193	61	22	specific	specific	ADJ
admet-193	61	23	descriptors	descriptor	NOUN
admet-193	61	24	on	on	ADP
admet-193	61	25	the	the	DET
admet-193	61	26	predicted	predict	VERB
admet-193	61	27	solubility	solubility	NOUN
admet-193	61	28	.	.	PUNCT
admet-193	62	1	in	in	ADP
admet-193	62	2	the	the	DET
admet-193	62	3	database	database	NOUN
admet-193	62	4	construction	construction	NOUN
admet-193	62	5	,	,	PUNCT
admet-193	62	6	intrinsic	intrinsic	ADJ
admet-193	62	7	solubility	solubility	NOUN
admet-193	62	8	(	(	PUNCT
admet-193	62	9	s0	s0	PROPN
admet-193	62	10	)	)	PUNCT
admet-193	62	11	values	value	NOUN
admet-193	62	12	were	be	AUX
admet-193	62	13	mostly	mostly	ADV
admet-193	62	14	derived	derive	VERB
admet-193	62	15	from	from	ADP
admet-193	62	16	(	(	PUNCT
admet-193	62	17	a	a	X
admet-193	62	18	)	)	PUNCT
admet-193	62	19	sw	sw	PROPN
admet-193	62	20	aqueous	aqueous	PROPN
admet-193	62	21	solubility	solubility	NOUN
admet-193	62	22	determined	determine	VERB
admet-193	62	23	in	in	ADP
admet-193	62	24	distilled	distilled	ADJ
admet-193	62	25	water	water	NOUN
admet-193	62	26	,	,	PUNCT
admet-193	62	27	often	often	ADV
admet-193	62	28	with	with	ADP
admet-193	62	29	ph	ph	NOUN
admet-193	62	30	not	not	PART
admet-193	62	31	reported	report	VERB
admet-193	62	32	,	,	PUNCT
admet-193	62	33	(	(	PUNCT
admet-193	62	34	b	b	X
admet-193	62	35	)	)	PUNCT
admet-193	62	36	sph	sph	NOUN
admet-193	62	37	single	single	ADJ
admet-193	62	38	-	-	PUNCT
admet-193	62	39	ph	ph	ADJ
admet-193	62	40	buffer	buffer	NOUN
admet-193	62	41	values	value	NOUN
admet-193	62	42	,	,	PUNCT
admet-193	62	43	and	and	CCONJ
admet-193	62	44	(	(	PUNCT
admet-193	62	45	c	c	NOUN
admet-193	62	46	)	)	PUNCT
admet-193	62	47	multiple	multiple	ADJ
admet-193	62	48	-	-	PUNCT
admet-193	62	49	ph	ph	ADJ
admet-193	62	50	buffer	buffer	NOUN
admet-193	62	51	sph	sph	NOUN
admet-193	62	52	values	value	NOUN
admet-193	62	53	(	(	PUNCT
admet-193	62	54	log	log	PROPN
admet-193	62	55	s	s	X
admet-193	62	56	vs.	vs.	X
admet-193	62	57	ph	ph	NOUN
admet-193	62	58	)	)	PUNCT
admet-193	62	59	.	.	PUNCT
admet-193	63	1	in	in	ADP
admet-193	63	2	cases	case	NOUN
admet-193	63	3	(	(	PUNCT
admet-193	63	4	a	a	NOUN
admet-193	63	5	)	)	PUNCT
admet-193	63	6	and	and	CCONJ
admet-193	63	7	(	(	PUNCT
admet-193	63	8	b	b	NOUN
admet-193	63	9	)	)	PUNCT
admet-193	63	10	,	,	PUNCT
admet-193	63	11	the	the	DET
admet-193	63	12	henderson	henderson	PROPN
admet-193	63	13	-	-	PUNCT
admet-193	63	14	hasselbalch	hasselbalch	PROPN
admet-193	63	15	equation	equation	NOUN
admet-193	63	16	(	(	PUNCT
admet-193	63	17	discussed	discuss	VERB
admet-193	63	18	below	below	ADV
admet-193	63	19	)	)	PUNCT
admet-193	63	20	was	be	AUX
admet-193	63	21	assumed	assume	VERB
admet-193	63	22	to	to	PART
admet-193	63	23	be	be	AUX
admet-193	63	24	valid	valid	ADJ
admet-193	63	25	.	.	PUNCT
admet-193	64	1	the	the	DET
admet-193	64	2	pdisol	pdisol	ADJ
admet-193	64	3	-	-	PUNCT
admet-193	64	4	x	x	NOUN
admet-193	64	5	program	program	NOUN
admet-193	64	6	(	(	PUNCT
admet-193	64	7	in	in	ADP
admet-193	64	8	-	-	PUNCT
admet-193	64	9	adme	adme	NOUN
admet-193	64	10	research	research	NOUN
admet-193	64	11	;	;	PUNCT
admet-193	64	12	www.in-adme.com/pdisol_x.html	www.in-adme.com/pdisol_x.html	PROPN
admet-193	64	13	)	)	PUNCT
admet-193	64	14	was	be	AUX
admet-193	64	15	used	use	VERB
admet-193	64	16	to	to	PART
admet-193	64	17	determine	determine	VERB
admet-193	64	18	the	the	DET
admet-193	64	19	s0	s0	PROPN
admet-193	64	20	values	value	NOUN
admet-193	64	21	from	from	ADP
admet-193	64	22	the	the	DET
admet-193	64	23	reported	report	VERB
admet-193	64	24	sw	sw	PROPN
admet-193	64	25	and	and	CCONJ
admet-193	64	26	sph	sph	PROPN
admet-193	64	27	data	data	PROPN
admet-193	64	28	,	,	PUNCT
admet-193	64	29	as	as	SCONJ
admet-193	64	30	described	describe	VERB
admet-193	64	31	in	in	ADP
admet-193	64	32	völgyi	völgyi	PROPN
admet-193	64	33	et	et	PROPN
admet-193	64	34	al	al	PROPN
admet-193	64	35	.	.	PUNCT
admet-193	65	1	[	[	X
admet-193	65	2	32	32	NUM
admet-193	65	3	]	]	PUNCT
admet-193	65	4	and	and	CCONJ
admet-193	65	5	avdeef	avdeef	NOUN
admet-193	66	1	[	[	X
admet-193	66	2	33,34	33,34	NOUN
admet-193	66	3	]	]	PUNCT
admet-193	66	4	.	.	PUNCT
admet-193	67	1	data	datum	NOUN
admet-193	67	2	the	the	DET
admet-193	67	3	4557	4557	NUM
admet-193	67	4	set	set	NOUN
admet-193	67	5	of	of	ADP
admet-193	67	6	measured	measure	VERB
admet-193	67	7	solubility	solubility	NOUN
admet-193	67	8	values	value	NOUN
admet-193	67	9	used	use	VERB
admet-193	67	10	to	to	PART
admet-193	67	11	deduce	deduce	VERB
admet-193	67	12	the	the	DET
admet-193	67	13	intrinsic	intrinsic	ADJ
admet-193	67	14	solubility	solubility	NOUN
admet-193	67	15	(	(	PUNCT
admet-193	67	16	s0	s0	PROPN
admet-193	67	17	)	)	PUNCT
admet-193	67	18	database	database	NOUN
admet-193	67	19	were	be	AUX
admet-193	67	20	collected	collect	VERB
admet-193	67	21	from	from	ADP
admet-193	67	22	four	four	NUM
admet-193	67	23	secondary	secondary	ADJ
admet-193	67	24	sources	source	NOUN
admet-193	67	25	(	(	PUNCT
admet-193	67	26	57	57	NUM
admet-193	67	27	%	%	NOUN
admet-193	67	28	)	)	PUNCT
admet-193	67	29	and	and	CCONJ
admet-193	67	30	the	the	DET
admet-193	67	31	rest	rest	NOUN
admet-193	67	32	from	from	ADP
admet-193	67	33	primary	primary	ADJ
admet-193	67	34	sources	source	NOUN
admet-193	67	35	(	(	PUNCT
admet-193	67	36	43	43	NUM
admet-193	67	37	%	%	NOUN
admet-193	67	38	):	):	PUNCT
admet-193	67	39			NOUN
admet-193	67	40	physprop	physprop	PROPN
admet-193	67	41	database	database	NOUN
admet-193	67	42	(	(	PUNCT
admet-193	67	43	sep	sep	PROPN
admet-193	67	44	.	.	PROPN
admet-193	67	45	1999	1999	NUM
admet-193	68	1	version	version	NOUN
admet-193	68	2	:	:	PUNCT
admet-193	68	3	6356	6356	NUM
admet-193	68	4	measured	measure	VERB
admet-193	68	5	water	water	NOUN
admet-193	68	6	solubility	solubility	NOUN
admet-193	68	7	,	,	PUNCT
admet-193	68	8	sw	sw	PROPN
admet-193	68	9	)	)	PUNCT
admet-193	69	1	[	[	X
admet-193	69	2	20,21	20,21	NUM
admet-193	69	3	]	]	PUNCT
admet-193	69	4	:	:	PUNCT
admet-193	69	5	1327	1327	NUM
admet-193	69	6	shake	shake	NOUN
admet-193	69	7	-	-	PUNCT
admet-193	69	8	flask	flask	NOUN
admet-193	69	9	values	value	NOUN
admet-193	69	10	were	be	AUX
admet-193	69	11	selected	select	VERB
admet-193	69	12	of	of	ADP
admet-193	69	13	molecules	molecule	NOUN
admet-193	69	14	which	which	PRON
admet-193	69	15	were	be	AUX
admet-193	69	16	not	not	PART
admet-193	69	17	appreciably	appreciably	ADV
admet-193	69	18	ionized	ionize	VERB
admet-193	69	19	at	at	ADP
admet-193	69	20	ph~7	ph~7	NOUN
admet-193	69	21	.	.	PUNCT
admet-193	70	1	filters	filter	NOUN
admet-193	70	2	used	use	VERB
admet-193	70	3	to	to	PART
admet-193	70	4	exclude	exclude	VERB
admet-193	70	5	compounds	compound	NOUN
admet-193	70	6	were	be	AUX
admet-193	70	7	:	:	PUNCT
admet-193	70	8	(	(	PUNCT
admet-193	70	9	a	a	X
admet-193	70	10	)	)	PUNCT
admet-193	70	11	melting	melting	NOUN
admet-193	70	12	point	point	NOUN
admet-193	70	13	<	<	X
admet-193	70	14	40	40	NUM
admet-193	70	15	°	°	NOUN
admet-193	70	16	c	c	NOUN
admet-193	70	17	,	,	PUNCT
admet-193	70	18	(	(	PUNCT
admet-193	70	19	b	b	X
admet-193	70	20	)	)	PUNCT
admet-193	70	21	log	log	NOUN
admet-193	70	22	sw	sw	PROPN
admet-193	70	23	<	<	X
admet-193	70	24	-8	-8	NOUN
admet-193	70	25	or	or	CCONJ
admet-193	70	26	>	>	X
admet-193	70	27	0	0	NUM
admet-193	70	28	,	,	PUNCT
admet-193	70	29	(	(	PUNCT
admet-193	70	30	c	c	NOUN
admet-193	70	31	)	)	PUNCT
admet-193	70	32	surfactants	surfactant	NOUN
admet-193	70	33	or	or	CCONJ
admet-193	70	34	compounds	compound	NOUN
admet-193	70	35	with	with	ADP
admet-193	70	36	long	long	ADJ
admet-193	70	37	aliphatic	aliphatic	ADJ
admet-193	70	38	chains	chain	NOUN
admet-193	70	39	,	,	PUNCT
admet-193	70	40	(	(	PUNCT
admet-193	70	41	d	d	X
admet-193	70	42	)	)	PUNCT
admet-193	70	43	multi	multi	ADJ
admet-193	70	44	-	-	ADJ
admet-193	70	45	ring	ring	ADJ
admet-193	70	46	aromatic	aromatic	ADJ
admet-193	70	47	hydrocarbons	hydrocarbon	NOUN
admet-193	70	48	,	,	PUNCT
admet-193	70	49	(	(	PUNCT
admet-193	70	50	e	e	NOUN
admet-193	70	51	)	)	PUNCT
admet-193	70	52	peroxides	peroxide	NOUN
admet-193	70	53	,	,	PUNCT
admet-193	70	54	(	(	PUNCT
admet-193	70	55	f	f	X
admet-193	70	56	)	)	PUNCT
admet-193	70	57	carboxylic	carboxylic	ADJ
admet-193	70	58	acids	acid	NOUN
admet-193	70	59	,	,	PUNCT
admet-193	70	60	(	(	PUNCT
admet-193	70	61	g	g	NOUN
admet-193	70	62	)	)	PUNCT
admet-193	70	63	salts	salt	NOUN
admet-193	70	64	/	/	SYM
admet-193	70	65	complexes	complex	NOUN
admet-193	70	66	with	with	ADP
admet-193	70	67	chloride	chloride	NOUN
admet-193	70	68	,	,	PUNCT
admet-193	70	69	bromide	bromide	NOUN
admet-193	70	70	,	,	PUNCT
admet-193	70	71	iodide	iodide	NOUN
admet-193	70	72	,	,	PUNCT
admet-193	70	73	sulfate	sulfate	NOUN
admet-193	70	74	,	,	PUNCT
admet-193	70	75	phosphate	phosphate	NOUN
admet-193	70	76	,	,	PUNCT
admet-193	70	77	sodium	sodium	NOUN
admet-193	70	78	,	,	PUNCT
admet-193	70	79	potassium	potassium	NOUN
admet-193	70	80	,	,	PUNCT
admet-193	70	81	lithium	lithium	NOUN
admet-193	70	82	,	,	PUNCT
admet-193	70	83	calcium	calcium	NOUN
admet-193	70	84	,	,	PUNCT
admet-193	70	85	magnesium	magnesium	NOUN
admet-193	70	86	,	,	PUNCT
admet-193	70	87	zinc	zinc	NOUN
admet-193	70	88	,	,	PUNCT
admet-193	70	89	copper	copper	NOUN
admet-193	70	90	,	,	PUNCT
admet-193	70	91	arsenic	arsenic	NOUN
admet-193	70	92	,	,	PUNCT
admet-193	70	93	mercury	mercury	NOUN
admet-193	70	94	,	,	PUNCT
admet-193	70	95	lead	lead	NOUN
admet-193	70	96	,	,	PUNCT
admet-193	70	97	antimony	antimony	NOUN
admet-193	70	98	,	,	PUNCT
admet-193	70	99	silver	silver	NOUN
admet-193	70	100	,	,	PUNCT
admet-193	70	101	silicon	silicon	NOUN
admet-193	70	102	,	,	PUNCT
admet-193	70	103	tin	tin	NOUN
admet-193	70	104	,	,	PUNCT
admet-193	70	105	etc	etc	X
admet-193	70	106	.	.	X
admet-193	70	107	,	,	PUNCT
admet-193	70	108	(	(	PUNCT
admet-193	70	109	h	h	NOUN
admet-193	70	110	)	)	PUNCT
admet-193	70	111	dyes	dye	NOUN
admet-193	70	112	or	or	CCONJ
admet-193	70	113	names	name	NOUN
admet-193	70	114	containing	contain	VERB
admet-193	70	115	color	color	NOUN
admet-193	70	116	,	,	PUNCT
admet-193	70	117	and	and	CCONJ
admet-193	70	118	(	(	PUNCT
admet-193	70	119	i	i	NOUN
admet-193	70	120	)	)	PUNCT
admet-193	70	121	herbicides	herbicide	NOUN
admet-193	70	122	,	,	PUNCT
admet-193	70	123	pesticides	pesticide	NOUN
admet-193	70	124	,	,	PUNCT
admet-193	70	125	insecticides	insecticide	NOUN
admet-193	70	126	,	,	PUNCT
admet-193	70	127	rodenticides	rodenticide	NOUN
admet-193	70	128	,	,	PUNCT
admet-193	70	129	and	and	CCONJ
admet-193	70	130	acaricides	acaricide	NOUN
admet-193	70	131	(	(	PUNCT
admet-193	70	132	as	as	SCONJ
admet-193	70	133	indicated	indicate	VERB
admet-193	70	134	by	by	ADP
admet-193	70	135	“	"	PUNCT
admet-193	70	136	tags	tag	NOUN
admet-193	70	137	”	"	PUNCT
admet-193	70	138	at	at	ADP
admet-193	70	139	the	the	DET
admet-193	70	140	royal	royal	ADJ
admet-193	70	141	society	society	NOUN
admet-193	70	142	of	of	ADP
admet-193	70	143	chemistry	chemistry	NOUN
admet-193	70	144	chemspider	chemspider	NOUN
admet-193	70	145	website	website	NOUN
admet-193	70	146	:	:	PUNCT
admet-193	70	147	http://www.chemspider.com/	http://www.chemspider.com/	NOUN
admet-193	70	148	)	)	PUNCT
admet-193	70	149	.	.	PUNCT
admet-193	71	1	of	of	ADP
admet-193	71	2	the	the	DET
admet-193	71	3	selected	select	VERB
admet-193	71	4	compounds	compound	NOUN
admet-193	71	5	,	,	PUNCT
admet-193	71	6	the	the	DET
admet-193	71	7	sw	sw	PROPN
admet-193	71	8	values	value	NOUN
admet-193	71	9	of	of	ADP
admet-193	71	10	1210	1210	NUM
admet-193	71	11	nonionizable	nonionizable	ADJ
admet-193	71	12	/	/	SYM
admet-193	71	13	nonionized	nonionize	VERB
admet-193	71	14	molecules	molecule	NOUN
admet-193	71	15	were	be	AUX
admet-193	71	16	taken	take	VERB
admet-193	71	17	to	to	PART
admet-193	71	18	be	be	AUX
admet-193	71	19	s0	s0	PROPN
admet-193	71	20	.	.	PUNCT
admet-193	72	1	the	the	DET
admet-193	72	2	remaining	remain	VERB
admet-193	72	3	117	117	NUM
admet-193	72	4	compounds	compound	NOUN
admet-193	72	5	were	be	AUX
admet-193	72	6	processed	process	VERB
admet-193	72	7	by	by	ADP
admet-193	72	8	pdisol	pdisol	ADJ
admet-193	72	9	-	-	PUNCT
admet-193	72	10	x	x	NOUN
admet-193	72	11	to	to	PART
admet-193	72	12	calculate	calculate	VERB
admet-193	72	13	s0	s0	NOUN
admet-193	72	14	and	and	CCONJ
admet-193	72	15	phsat	phsat	PROPN
admet-193	72	16	(	(	PUNCT
admet-193	72	17	ph	ph	NOUN
admet-193	72	18	of	of	ADP
admet-193	72	19	saturated	saturated	ADJ
admet-193	72	20	aqueous	aqueous	ADJ
admet-193	72	21	solution	solution	NOUN
admet-193	72	22	)	)	PUNCT
admet-193	72	23	from	from	ADP
admet-193	72	24	the	the	DET
admet-193	72	25	given	give	VERB
admet-193	72	26	sw	sw	PROPN
admet-193	72	27	and	and	CCONJ
admet-193	72	28	pka	pka	PROPN
admet-193	72	29	.	.	PUNCT
admet-193	73	1			PROPN
admet-193	73	2	handbook	handbook	NOUN
admet-193	73	3	of	of	ADP
admet-193	73	4	aqueous	aqueous	ADJ
admet-193	73	5	solubility	solubility	NOUN
admet-193	73	6	data	datum	NOUN
admet-193	73	7	[	[	X
admet-193	73	8	19	19	NUM
admet-193	73	9	]	]	SYM
admet-193	73	10	:	:	PUNCT
admet-193	73	11	1130	1130	NUM
admet-193	73	12	sw	sw	PROPN
admet-193	73	13	data	datum	NOUN
admet-193	73	14	were	be	AUX
admet-193	73	15	selected	select	VERB
admet-193	73	16	,	,	PUNCT
admet-193	73	17	with	with	ADP
admet-193	73	18	776	776	NUM
admet-193	73	19	values	value	NOUN
admet-193	73	20	subjected	subject	VERB
admet-193	73	21	to	to	ADP
admet-193	73	22	pdisol	pdisol	ADJ
admet-193	73	23	-	-	PUNCT
admet-193	73	24	x	x	NOUN
admet-193	73	25	analysis	analysis	NOUN
admet-193	73	26	to	to	PART
admet-193	73	27	determine	determine	VERB
admet-193	73	28	s0	s0	PROPN
admet-193	73	29	values	value	NOUN
admet-193	73	30	.	.	PUNCT
admet-193	74	1	a	a	DET
admet-193	74	2	few	few	ADJ
admet-193	74	3	of	of	ADP
admet-193	74	4	the	the	DET
admet-193	74	5	same	same	ADJ
admet-193	74	6	preceding	precede	VERB
admet-193	74	7	filters	filter	NOUN
admet-193	74	8	were	be	AUX
admet-193	74	9	used	use	VERB
admet-193	74	10	in	in	ADP
admet-193	74	11	the	the	DET
admet-193	74	12	selections	selection	NOUN
admet-193	74	13	.	.	PUNCT
admet-193	75	1			X
admet-193	75	2	analytical	analytical	ADJ
admet-193	75	3	profiles	profile	NOUN
admet-193	75	4	of	of	ADP
admet-193	75	5	drug	drug	NOUN
admet-193	75	6	substances	substance	NOUN
admet-193	75	7	[	[	X
admet-193	75	8	22	22	NUM
admet-193	75	9	]	]	X
admet-193	75	10	:	:	PUNCT
admet-193	75	11	all	all	DET
admet-193	75	12	39	39	NUM
admet-193	75	13	volumes	volume	NOUN
admet-193	75	14	of	of	ADP
admet-193	75	15	the	the	DET
admet-193	75	16	series	series	NOUN
admet-193	75	17	of	of	ADP
admet-193	75	18	monographs	monograph	NOUN
admet-193	75	19	were	be	AUX
admet-193	75	20	searched	search	VERB
admet-193	75	21	for	for	ADP
admet-193	75	22	quantitative	quantitative	ADJ
admet-193	75	23	solubility	solubility	NOUN
admet-193	75	24	data	datum	NOUN
admet-193	75	25	.	.	PUNCT
admet-193	76	1	monographs	monograph	NOUN
admet-193	76	2	on	on	ADP
admet-193	76	3	155	155	NUM
admet-193	76	4	molecules	molecule	NOUN
admet-193	76	5	were	be	AUX
admet-193	76	6	found	find	VERB
admet-193	76	7	to	to	PART
admet-193	76	8	be	be	AUX
admet-193	76	9	useful	useful	ADJ
admet-193	76	10	.	.	PUNCT
admet-193	77	1	most	most	ADJ
admet-193	77	2	of	of	ADP
admet-193	77	3	the	the	DET
admet-193	77	4	reported	report	VERB
admet-193	77	5	solubility	solubility	NOUN
admet-193	77	6	values	value	NOUN
admet-193	77	7	of	of	ADP
admet-193	77	8	ionizable	ionizable	ADJ
admet-193	77	9	molecules	molecule	NOUN
admet-193	77	10	were	be	AUX
admet-193	77	11	measured	measure	VERB
admet-193	77	12	in	in	ADP
admet-193	77	13	pure	pure	ADJ
admet-193	77	14	water	water	NOUN
admet-193	77	15	with	with	ADP
admet-193	77	16	unspecified	unspecified	ADJ
admet-193	77	17	saturation	saturation	NOUN
admet-193	77	18	ph	ph	VERB
admet-193	77	19	.	.	PROPN
admet-193	77	20	for	for	ADP
admet-193	77	21	those	those	DET
admet-193	77	22	ionizable	ionizable	ADJ
admet-193	77	23	molecules	molecule	NOUN
admet-193	77	24	which	which	PRON
admet-193	77	25	were	be	AUX
admet-193	77	26	not	not	PART
admet-193	77	27	salts	salt	NOUN
admet-193	77	28	,	,	PUNCT
admet-193	77	29	the	the	DET
admet-193	77	30	intrinsic	intrinsic	ADJ
admet-193	77	31	values	value	NOUN
admet-193	77	32	were	be	AUX
admet-193	77	33	calculated	calculate	VERB
admet-193	77	34	by	by	ADP
admet-193	77	35	pdisol	pdisol	NOUN
admet-193	77	36	-	-	PUNCT
admet-193	77	37	x.	x.	NOUN
admet-193	77	38	unfortunately	unfortunately	ADV
admet-193	77	39	,	,	PUNCT
admet-193	77	40	the	the	DET
admet-193	77	41	solubility	solubility	NOUN
admet-193	77	42	accompanied	accompany	VERB
admet-193	77	43	scant	scant	ADJ
admet-193	77	44	experimental	experimental	ADJ
admet-193	77	45	detail	detail	NOUN
admet-193	77	46	(	(	PUNCT
admet-193	77	47	e.g.	e.g.	ADV
admet-193	77	48	,	,	PUNCT
admet-193	77	49	temperature	temperature	NOUN
admet-193	77	50	not	not	PART
admet-193	77	51	always	always	ADV
admet-193	77	52	reported	report	VERB
admet-193	77	53	)	)	PUNCT
admet-193	77	54	,	,	PUNCT
admet-193	77	55	and	and	CCONJ
admet-193	77	56	many	many	ADJ
admet-193	77	57	entries	entry	NOUN
admet-193	77	58	were	be	AUX
admet-193	77	59	referenced	reference	VERB
admet-193	77	60	as	as	ADP
admet-193	77	61	‘	'	PUNCT
admet-193	77	62	personal	personal	ADJ
admet-193	77	63	communication	communication	NOUN
admet-193	77	64	.	.	PUNCT
admet-193	77	65	’	'	PUNCT
admet-193	78	1	but	but	CCONJ
admet-193	78	2	there	there	PRON
admet-193	78	3	are	be	VERB
admet-193	78	4	several	several	ADJ
admet-193	78	5	high	high	ADJ
admet-193	78	6	-	-	PUNCT
admet-193	78	7	quality	quality	NOUN
admet-193	78	8	log	log	NOUN
admet-193	78	9	s	s	NOUN
admet-193	78	10	ph	ph	ADJ
admet-193	78	11	data	data	NOUN
admet-193	78	12	sets	set	NOUN
admet-193	78	13	in	in	ADP
admet-193	78	14	the	the	DET
admet-193	78	15	monographs	monograph	NOUN
admet-193	78	16	.	.	PUNCT
admet-193	79	1			X
admet-193	79	2	miscellaneous	miscellaneous	ADJ
admet-193	79	3	publications	publication	NOUN
admet-193	79	4	(	(	PUNCT
admet-193	79	5	shake	shake	NOUN
admet-193	79	6	-	-	PUNCT
admet-193	79	7	flask	flask	NOUN
admet-193	79	8	data	datum	NOUN
admet-193	79	9	,	,	PUNCT
admet-193	79	10	some	some	PRON
admet-193	79	11	from	from	ADP
admet-193	79	12	secondary	secondary	ADJ
admet-193	79	13	sources	source	NOUN
admet-193	79	14	):	):	PUNCT
admet-193	79	15	852	852	NUM
admet-193	79	16	s0	s0	NOUN
admet-193	79	17	values	value	NOUN
admet-193	79	18	(	(	PUNCT
admet-193	79	19	taken	take	VERB
admet-193	79	20	as	as	SCONJ
admet-193	79	21	reported	report	VERB
admet-193	79	22	)	)	PUNCT
admet-193	79	23	.	.	PUNCT
admet-193	80	1			PROPN
admet-193	80	2	cheqsol	cheqsol	PROPN
admet-193	80	3	s0	s0	PROPN
admet-193	80	4	data	data	PROPN
admet-193	80	5	(	(	PUNCT
admet-193	80	6	potentiometric	potentiometric	ADJ
admet-193	80	7	):	):	PUNCT
admet-193	80	8	201	201	NUM
admet-193	80	9	values	value	NOUN
admet-193	80	10	for	for	ADP
admet-193	80	11	151	151	NUM
admet-193	80	12	molecules	molecule	NOUN
admet-193	80	13	collected	collect	VERB
admet-193	80	14	from	from	ADP
admet-193	80	15	several	several	ADJ
admet-193	80	16	publications	publication	NOUN
admet-193	80	17	(	(	PUNCT
admet-193	80	18	stuart	stuart	PROPN
admet-193	80	19	and	and	CCONJ
admet-193	80	20	box	box	PROPN
admet-193	81	1	[	[	X
admet-193	81	2	35	35	NUM
admet-193	81	3	]	]	X
admet-193	81	4	;	;	PUNCT
admet-193	81	5	sköld	sköld	NOUN
admet-193	81	6	et	et	NOUN
admet-193	81	7	al	al	PROPN
admet-193	81	8	.	.	PUNCT
admet-193	82	1	[	[	X
admet-193	82	2	36	36	NUM
admet-193	82	3	]	]	PUNCT
admet-193	82	4	;	;	PUNCT
admet-193	82	5	llinàs	llinàs	PROPN
admet-193	82	6	et	et	PROPN
admet-193	82	7	al	al	PROPN
admet-193	82	8	.	.	PUNCT
admet-193	83	1	[	[	X
admet-193	83	2	26,37	26,37	X
admet-193	83	3	]	]	X
admet-193	83	4	;	;	PUNCT
admet-193	83	5	box	box	PROPN
admet-193	83	6	et	et	PROPN
admet-193	83	7	al	al	PROPN
admet-193	83	8	.	.	PUNCT
admet-193	84	1	[	[	X
admet-193	84	2	38	38	NUM
admet-193	84	3	]	]	PUNCT
admet-193	84	4	;	;	PUNCT
admet-193	84	5	hopfinger	hopfinger	PROPN
admet-193	84	6	et	et	PROPN
admet-193	84	7	al	al	PROPN
admet-193	84	8	.	.	PUNCT
admet-193	85	1	[	[	X
admet-193	85	2	27	27	NUM
admet-193	85	3	]	]	PUNCT
admet-193	85	4	;	;	PUNCT
admet-193	85	5	narasimham	narasimham	PROPN
admet-193	85	6	et	et	PROPN
admet-193	85	7	al	al	PROPN
admet-193	85	8	.	.	PUNCT
admet-193	86	1	[	[	X
admet-193	86	2	39	39	NUM
admet-193	86	3	]	]	PUNCT
admet-193	86	4	;	;	PUNCT
admet-193	86	5	hsieh	hsieh	PROPN
admet-193	86	6	et	et	PROPN
admet-193	86	7	al	al	PROPN
admet-193	86	8	.	.	PUNCT
admet-193	87	1	[	[	X
admet-193	87	2	40	40	NUM
admet-193	87	3	]	]	X
admet-193	87	4	;	;	PUNCT
admet-193	87	5	comer	comer	NOUN
admet-193	87	6	et	et	PROPN
admet-193	87	7	al	al	PROPN
admet-193	87	8	.	.	PUNCT
admet-193	88	1	[	[	X
admet-193	88	2	41	41	NUM
admet-193	88	3	]	]	X
admet-193	88	4	;	;	PUNCT
admet-193	88	5	palmer	palmer	PROPN
admet-193	88	6	and	and	CCONJ
admet-193	88	7	mitchell	mitchell	PROPN
admet-193	88	8	[	[	X
admet-193	88	9	17	17	NUM
admet-193	88	10	]	]	X
admet-193	88	11	;	;	PUNCT
admet-193	88	12	schönherr	schönherr	PROPN
admet-193	88	13	et	et	PROPN
admet-193	88	14	al	al	PROPN
admet-193	88	15	.	.	PUNCT
admet-193	89	1	[	[	X
admet-193	89	2	42	42	NUM
admet-193	89	3	]	]	PUNCT
admet-193	89	4	)	)	PUNCT
admet-193	89	5	.	.	PUNCT
admet-193	90	1	http://rdkit.readthedocs.org/en/latest/	http://rdkit.readthedocs.org/en/latest/	PROPN
admet-193	90	2	http://qsardb.org/repository/handle/10967/104	http://qsardb.org/repository/handle/10967/104	PROPN
admet-193	90	3	http://www.chemspider.com/	http://www.chemspider.com/	PROPN
admet-193	90	4	admet	admet	PROPN
admet-193	90	5	&	&	CCONJ
admet-193	90	6	dmpk	dmpk	PROPN
admet-193	90	7	3(2	3(2	NUM
admet-193	90	8	)	)	PUNCT
admet-193	90	9	(	(	PUNCT
admet-193	90	10	2015	2015	NUM
admet-193	90	11	)	)	PUNCT
admet-193	90	12	84	84	NUM
admet-193	90	13	-	-	SYM
admet-193	90	14	109	109	NUM
admet-193	90	15	equilibrium	equilibrium	NOUN
admet-193	90	16	solubility	solubility	NOUN
admet-193	90	17	measurements	measurement	NOUN
admet-193	90	18	improvements	improvement	NOUN
admet-193	90	19	doi	doi	NOUN
admet-193	90	20	:	:	PUNCT
admet-193	90	21	10.5599	10.5599	NUM
admet-193	90	22	/	/	SYM
admet-193	90	23	admet.3.2.193	admet.3.2.193	ADJ
admet-193	90	24	87	87	NUM
admet-193	90	25			NOUN
admet-193	90	26	dissolution	dissolution	NOUN
admet-193	90	27	template	template	NOUN
admet-193	90	28	titration	titration	NOUN
admet-193	90	29	(	(	PUNCT
admet-193	90	30	dtt	dtt	NOUN
admet-193	90	31	)	)	PUNCT
admet-193	90	32	s0	s0	PROPN
admet-193	90	33	data	datum	NOUN
admet-193	90	34	(	(	PUNCT
admet-193	90	35	potentiometric	potentiometric	ADJ
admet-193	90	36	):	):	PUNCT
admet-193	90	37	75	75	NUM
admet-193	90	38	published	publish	VERB
admet-193	90	39	values	value	NOUN
admet-193	90	40	were	be	AUX
admet-193	90	41	collected	collect	VERB
admet-193	90	42	(	(	PUNCT
admet-193	90	43	avdeef	avdeef	VERB
admet-193	90	44	[	[	X
admet-193	90	45	43,46	43,46	NOUN
admet-193	90	46	]	]	PUNCT
admet-193	90	47	;	;	PUNCT
admet-193	90	48	avdeef	avdeef	PROPN
admet-193	90	49	et	et	PROPN
admet-193	90	50	al	al	PROPN
admet-193	90	51	.	.	PUNCT
admet-193	91	1	[	[	X
admet-193	91	2	44	44	NUM
admet-193	91	3	]	]	PUNCT
admet-193	91	4	;	;	PUNCT
admet-193	91	5	avdeef	avdeef	NOUN
admet-193	91	6	and	and	CCONJ
admet-193	91	7	berger	berger	PROPN
admet-193	92	1	[	[	X
admet-193	92	2	45	45	NUM
admet-193	92	3	]	]	X
admet-193	92	4	;	;	PUNCT
admet-193	92	5	faller	faller	NOUN
admet-193	92	6	and	and	CCONJ
admet-193	92	7	wohnsland	wohnsland	NOUN
admet-193	93	1	[	[	X
admet-193	93	2	47	47	NUM
admet-193	93	3	]	]	PUNCT
admet-193	93	4	;	;	PUNCT
admet-193	93	5	bergström	bergström	NOUN
admet-193	93	6	et	et	PROPN
admet-193	93	7	al	al	PROPN
admet-193	93	8	.	.	PUNCT
admet-193	94	1	[	[	X
admet-193	94	2	48	48	NUM
admet-193	94	3	]	]	PUNCT
admet-193	94	4	;	;	PUNCT
admet-193	94	5	fioritto	fioritto	PROPN
admet-193	94	6	et	et	PROPN
admet-193	94	7	al	al	PROPN
admet-193	94	8	.	.	PUNCT
admet-193	95	1	[	[	X
admet-193	95	2	49	49	NUM
admet-193	95	3	]	]	PUNCT
admet-193	95	4	;	;	PUNCT
admet-193	95	5	ottaviani	ottaviani	PROPN
admet-193	95	6	et	et	PROPN
admet-193	95	7	al	al	PROPN
admet-193	95	8	.	.	PUNCT
admet-193	96	1	[	[	X
admet-193	96	2	50	50	NUM
admet-193	96	3	]	]	NUM
admet-193	96	4	)	)	PUNCT
admet-193	96	5	.	.	PUNCT
admet-193	97	1			NOUN
admet-193	98	1	rytting	rytte	VERB
admet-193	98	2	et	et	PROPN
admet-193	98	3	al	al	PROPN
admet-193	98	4	.	.	PUNCT
admet-193	99	1	[	[	X
admet-193	99	2	24	24	NUM
admet-193	99	3	]	]	X
admet-193	99	4	free	free	ADJ
admet-193	99	5	-	-	PUNCT
admet-193	99	6	base	base	NOUN
admet-193	99	7	and	and	CCONJ
admet-193	99	8	-acid	-acid	ADJ
admet-193	99	9	(	(	PUNCT
admet-193	99	10	no	no	DET
admet-193	99	11	salts	salt	NOUN
admet-193	99	12	used	use	VERB
admet-193	99	13	)	)	PUNCT
admet-193	99	14	shake	shake	NOUN
admet-193	99	15	-	-	PUNCT
admet-193	99	16	flask	flask	NOUN
admet-193	99	17	sw	sw	PROPN
admet-193	99	18	:	:	PUNCT
admet-193	99	19	solubility	solubility	NOUN
admet-193	99	20	of	of	ADP
admet-193	99	21	122	122	NUM
admet-193	99	22	molecules	molecule	NOUN
admet-193	99	23	were	be	AUX
admet-193	99	24	gathered	gather	VERB
admet-193	99	25	,	,	PUNCT
admet-193	99	26	all	all	PRON
admet-193	99	27	measured	measure	VERB
admet-193	99	28	in	in	ADP
admet-193	99	29	one	one	NUM
admet-193	99	30	laboratory	laboratory	NOUN
admet-193	99	31	,	,	PUNCT
admet-193	99	32	with	with	SCONJ
admet-193	99	33	s0	s0	PROPN
admet-193	99	34	calculated	calculate	VERB
admet-193	99	35	by	by	ADP
admet-193	99	36	pdisol	pdisol	ADJ
admet-193	99	37	-	-	PUNCT
admet-193	99	38	x.	x.	NOUN
admet-193	99	39			NOUN
admet-193	99	40	shake	shake	NOUN
admet-193	99	41	-	-	PUNCT
admet-193	99	42	flask	flask	NOUN
admet-193	99	43	measurements	measurement	NOUN
admet-193	99	44	in	in	ADP
admet-193	99	45	two	two	NUM
admet-193	99	46	or	or	CCONJ
admet-193	99	47	more	more	ADJ
admet-193	99	48	ph	ph	ADJ
admet-193	99	49	buffers	buffer	NOUN
admet-193	99	50	(	(	PUNCT
admet-193	99	51	primary	primary	ADJ
admet-193	99	52	sources	source	NOUN
admet-193	99	53	):	):	PUNCT
admet-193	99	54	697	697	NUM
admet-193	99	55	molecules	molecule	NOUN
admet-193	99	56	with	with	ADP
admet-193	99	57	s	s	NOUN
admet-193	99	58	-	-	PUNCT
admet-193	99	59	ph	ph	ADJ
admet-193	99	60	data	datum	NOUN
admet-193	99	61	were	be	AUX
admet-193	99	62	analyzed	analyze	VERB
admet-193	99	63	by	by	ADP
admet-193	99	64	pdisol	pdisol	ADJ
admet-193	99	65	-	-	PUNCT
admet-193	99	66	x	x	NOUN
admet-193	99	67	to	to	PART
admet-193	99	68	determine	determine	VERB
admet-193	99	69	s0	s0	PROPN
admet-193	99	70	.	.	PUNCT
admet-193	100	1	figure	figure	PROPN
admet-193	100	2	1a	1a	PROPN
admet-193	100	3	shows	show	VERB
admet-193	100	4	the	the	DET
admet-193	100	5	frequency	frequency	NOUN
admet-193	100	6	distribution	distribution	NOUN
admet-193	100	7	of	of	ADP
admet-193	100	8	the	the	DET
admet-193	100	9	multi	multi	ADJ
admet-193	100	10	-	-	ADJ
admet-193	100	11	ph	ph	ADJ
admet-193	100	12	data	datum	NOUN
admet-193	100	13	.	.	PUNCT
admet-193	101	1	there	there	PRON
admet-193	101	2	were	be	VERB
admet-193	101	3	101	101	NUM
admet-193	101	4	studies	study	NOUN
admet-193	101	5	(	(	PUNCT
admet-193	101	6	14	14	NUM
admet-193	101	7	%	%	NOUN
admet-193	101	8	)	)	PUNCT
admet-193	101	9	with	with	ADP
admet-193	101	10	2	2	NUM
admet-193	101	11	ph	ph	NOUN
admet-193	101	12	/	/	SYM
admet-193	101	13	assay	assay	NOUN
admet-193	101	14	and	and	CCONJ
admet-193	101	15	164	164	NUM
admet-193	101	16	studies	study	NOUN
admet-193	101	17	(	(	PUNCT
admet-193	101	18	24	24	NUM
admet-193	101	19	%	%	NOUN
admet-193	101	20	)	)	PUNCT
admet-193	101	21	with	with	ADP
admet-193	101	22	3	3	NUM
admet-193	101	23	-	-	SYM
admet-193	101	24	5	5	NUM
admet-193	101	25	ph	ph	NOUN
admet-193	101	26	/	/	SYM
admet-193	101	27	assay	assay	NOUN
admet-193	101	28	.	.	PUNCT
admet-193	102	1	eight	eight	NUM
admet-193	102	2	studies	study	NOUN
admet-193	102	3	were	be	AUX
admet-193	102	4	reported	report	VERB
admet-193	102	5	,	,	PUNCT
admet-193	102	6	each	each	PRON
admet-193	102	7	with	with	ADP
admet-193	102	8	more	more	ADJ
admet-193	102	9	than	than	ADP
admet-193	102	10	40	40	NUM
admet-193	102	11	ph	ph	ADJ
admet-193	102	12	points	point	NOUN
admet-193	102	13	defining	define	VERB
admet-193	102	14	the	the	DET
admet-193	102	15	log	log	NOUN
admet-193	102	16	s	s	NOUN
admet-193	102	17	-	-	PUNCT
admet-193	102	18	ph	ph	ADJ
admet-193	102	19	profile	profile	NOUN
admet-193	102	20	.	.	PUNCT
admet-193	103	1	the	the	DET
admet-193	103	2	median	median	NOUN
admet-193	103	3	in	in	ADP
admet-193	103	4	the	the	DET
admet-193	103	5	set	set	NOUN
admet-193	103	6	of	of	ADP
admet-193	103	7	697	697	NUM
admet-193	103	8	compounds	compound	NOUN
admet-193	103	9	was	be	AUX
admet-193	103	10	seven	seven	NUM
admet-193	103	11	s	s	NOUN
admet-193	103	12	-	-	PUNCT
admet-193	103	13	ph	ph	ADJ
admet-193	103	14	points	point	NOUN
admet-193	103	15	per	per	ADP
admet-193	103	16	molecule	molecule	NOUN
admet-193	103	17	.	.	PUNCT
admet-193	104	1	most	most	ADJ
admet-193	104	2	of	of	ADP
admet-193	104	3	the	the	DET
admet-193	104	4	published	publish	VERB
admet-193	104	5	data	datum	NOUN
admet-193	104	6	were	be	AUX
admet-193	104	7	presented	present	VERB
admet-193	104	8	graphically	graphically	ADV
admet-193	104	9	as	as	ADP
admet-193	104	10	log	log	PROPN
admet-193	104	11	s	s	PART
admet-193	104	12	vs.	vs.	ADP
admet-193	104	13	ph	ph	ADJ
admet-193	104	14	plots	plot	NOUN
admet-193	104	15	.	.	PUNCT
admet-193	105	1	the	the	DET
admet-193	105	2	process	process	NOUN
admet-193	105	3	of	of	ADP
admet-193	105	4	digitizing	digitize	VERB
admet-193	105	5	data	datum	NOUN
admet-193	105	6	from	from	ADP
admet-193	105	7	plots	plot	NOUN
admet-193	105	8	introduced	introduce	VERB
admet-193	105	9	some	some	DET
admet-193	105	10	small	small	ADJ
admet-193	105	11	error	error	NOUN
admet-193	105	12	.	.	PUNCT
admet-193	106	1	it	it	PRON
admet-193	106	2	was	be	AUX
admet-193	106	3	not	not	PART
admet-193	106	4	possible	possible	ADJ
admet-193	106	5	to	to	PART
admet-193	106	6	digitize	digitize	VERB
admet-193	106	7	the	the	DET
admet-193	106	8	graphs	graph	NOUN
admet-193	106	9	entirely	entirely	ADV
admet-193	106	10	if	if	SCONJ
admet-193	106	11	the	the	DET
admet-193	106	12	molecules	molecule	NOUN
admet-193	106	13	were	be	AUX
admet-193	106	14	low	low	ADV
admet-193	106	15	soluble	soluble	ADJ
admet-193	106	16	and	and	CCONJ
admet-193	106	17	the	the	DET
admet-193	106	18	plots	plot	NOUN
admet-193	106	19	were	be	AUX
admet-193	106	20	in	in	ADP
admet-193	106	21	non	non	ADJ
admet-193	106	22	-	-	ADJ
admet-193	106	23	logarithmic	logarithmic	ADJ
admet-193	106	24	s	s	PART
admet-193	106	25	units	unit	NOUN
admet-193	106	26	vs.	vs.	ADP
admet-193	106	27	ph	ph	PROPN
admet-193	106	28	.	.	PROPN
admet-193	107	1	a	a	DET
admet-193	107	2	large	large	ADJ
admet-193	107	3	fraction	fraction	NOUN
admet-193	107	4	of	of	ADP
admet-193	107	5	the	the	DET
admet-193	107	6	primary	primary	ADJ
admet-193	107	7	source	source	NOUN
admet-193	107	8	data	datum	NOUN
admet-193	107	9	originated	originate	VERB
admet-193	107	10	from	from	ADP
admet-193	107	11	five	five	NUM
admet-193	107	12	journals	journal	NOUN
admet-193	107	13	(	(	PUNCT
admet-193	107	14	in	in	ADP
admet-193	107	15	rank	rank	NOUN
admet-193	107	16	order	order	NOUN
admet-193	107	17	):	):	PUNCT
admet-193	107	18	int	int	NOUN
admet-193	107	19	.	.	PUNCT
admet-193	108	1	j.	j.	PROPN
admet-193	108	2	pharm	pharm	PROPN
admet-193	108	3	.	.	PROPN
admet-193	108	4	,	,	PUNCT
admet-193	108	5	j.	j.	PROPN
admet-193	108	6	pharm	pharm	PROPN
admet-193	108	7	.	.	PUNCT
admet-193	109	1	sci	sci	PROPN
admet-193	109	2	.	.	PROPN
admet-193	109	3	,	,	PUNCT
admet-193	109	4	pharm	pharm	PROPN
admet-193	109	5	.	.	PUNCT
admet-193	110	1	res	re	NOUN
admet-193	110	2	.	.	PROPN
admet-193	110	3	,	,	PUNCT
admet-193	110	4	j.	j.	PROPN
admet-193	110	5	chem	chem	PROPN
admet-193	110	6	.	.	PUNCT
admet-193	111	1	eng	eng	PROPN
admet-193	111	2	.	.	PROPN
admet-193	111	3	data	data	PROPN
admet-193	111	4	,	,	PUNCT
admet-193	111	5	and	and	CCONJ
admet-193	111	6	eur	eur	PROPN
admet-193	111	7	.	.	PUNCT
admet-193	112	1	j.	j.	PROPN
admet-193	112	2	pharm	pharm	PROPN
admet-193	112	3	.	.	PUNCT
admet-193	113	1	sci	sci	PROPN
admet-193	113	2	.	.	PUNCT
admet-193	114	1	it	it	PRON
admet-193	114	2	is	be	AUX
admet-193	114	3	primarily	primarily	ADV
admet-193	114	4	from	from	ADP
admet-193	114	5	this	this	DET
admet-193	114	6	group	group	NOUN
admet-193	114	7	of	of	ADP
admet-193	114	8	697	697	NUM
admet-193	114	9	“	"	PUNCT
admet-193	114	10	gold	gold	ADJ
admet-193	114	11	standard	standard	NOUN
admet-193	114	12	”	"	PUNCT
admet-193	114	13	shake	shake	NOUN
admet-193	114	14	-	-	PUNCT
admet-193	114	15	flask	flask	NOUN
admet-193	114	16	multi	multi	ADJ
admet-193	114	17	-	-	ADJ
admet-193	114	18	ph	ph	ADJ
admet-193	114	19	measurements	measurement	NOUN
admet-193	114	20	that	that	PRON
admet-193	114	21	many	many	ADJ
admet-193	114	22	of	of	ADP
admet-193	114	23	the	the	DET
admet-193	114	24	suggestions	suggestion	NOUN
admet-193	114	25	below	below	ADV
admet-193	114	26	were	be	AUX
admet-193	114	27	formulated	formulate	VERB
admet-193	114	28	.	.	PUNCT
admet-193	115	1	the	the	DET
admet-193	115	2	assembled	assemble	VERB
admet-193	115	3	4557	4557	NUM
admet-193	115	4	intrinsic	intrinsic	ADJ
admet-193	115	5	solubility	solubility	NOUN
admet-193	115	6	set	set	VERB
admet-193	115	7	ranges	range	NOUN
admet-193	115	8	in	in	ADP
admet-193	115	9	log	log	NOUN
admet-193	115	10	s0	s0	PROPN
admet-193	115	11	from	from	ADP
admet-193	115	12	-11.6	-11.6	PRON
admet-193	115	13	to	to	ADP
admet-193	115	14	+1.8	+1.8	X
admet-193	115	15	(	(	PUNCT
admet-193	115	16	log	log	NOUN
admet-193	115	17	molarity	molarity	NOUN
admet-193	115	18	)	)	PUNCT
admet-193	115	19	.	.	PUNCT
admet-193	116	1	figure	figure	NOUN
admet-193	116	2	1b	1b	PROPN
admet-193	116	3	shows	show	VERB
admet-193	116	4	a	a	DET
admet-193	116	5	frequency	frequency	NOUN
admet-193	116	6	distribution	distribution	NOUN
admet-193	116	7	for	for	ADP
admet-193	116	8	the	the	DET
admet-193	116	9	set	set	NOUN
admet-193	116	10	.	.	PUNCT
admet-193	117	1	about	about	ADV
admet-193	117	2	40	40	NUM
admet-193	117	3	%	%	NOUN
admet-193	117	4	of	of	ADP
admet-193	117	5	the	the	DET
admet-193	117	6	compounds	compound	NOUN
admet-193	117	7	have	have	AUX
admet-193	117	8	log	log	NOUN
admet-193	117	9	s0	s0	NOUN
admet-193	117	10	between	between	ADP
admet-193	117	11	-6	-6	PROPN
admet-193	117	12	and	and	CCONJ
admet-193	117	13	-3	-3	PUNCT
admet-193	117	14	,	,	PUNCT
admet-193	117	15	the	the	DET
admet-193	117	16	typical	typical	ADJ
admet-193	117	17	range	range	NOUN
admet-193	117	18	of	of	ADP
admet-193	117	19	values	value	NOUN
admet-193	117	20	for	for	ADP
admet-193	117	21	research	research	NOUN
admet-193	117	22	compounds	compound	NOUN
admet-193	117	23	(	(	PUNCT
admet-193	117	24	faller	faller	NOUN
admet-193	117	25	and	and	CCONJ
admet-193	117	26	ertl	ertl	PROPN
admet-193	118	1	[	[	X
admet-193	118	2	18	18	NUM
admet-193	118	3	]	]	X
admet-193	118	4	;	;	PUNCT
admet-193	118	5	walters	walter	NOUN
admet-193	118	6	[	[	X
admet-193	118	7	28	28	NUM
admet-193	118	8	]	]	NUM
admet-193	118	9	)	)	PUNCT
admet-193	118	10	.	.	PUNCT
admet-193	119	1	the	the	DET
admet-193	119	2	median	median	ADJ
admet-193	119	3	log	log	NOUN
admet-193	119	4	s0	s0	NOUN
admet-193	119	5	of	of	ADP
admet-193	119	6	the	the	DET
admet-193	119	7	distribution	distribution	NOUN
admet-193	119	8	is	be	AUX
admet-193	119	9	-2.8	-2.8	ADJ
admet-193	119	10	.	.	PUNCT
admet-193	120	1	about	about	ADV
admet-193	120	2	5	5	NUM
admet-193	120	3	%	%	NOUN
admet-193	120	4	of	of	ADP
admet-193	120	5	the	the	DET
admet-193	120	6	molecules	molecule	NOUN
admet-193	120	7	have	have	AUX
admet-193	120	8	log	log	VERB
admet-193	120	9	s0	s0	PROPN
admet-193	120	10	<	<	X
admet-193	121	1	-6	-6	PROPN
admet-193	121	2	.	.	PUNCT
admet-193	122	1	the	the	DET
admet-193	122	2	least	least	ADV
admet-193	122	3	-	-	PUNCT
admet-193	122	4	soluble	soluble	ADJ
admet-193	122	5	molecules	molecule	NOUN
admet-193	122	6	(	(	PUNCT
admet-193	122	7	log	log	NOUN
admet-193	122	8	s0	s0	NOUN
admet-193	122	9	<	<	X
admet-193	122	10	-8	-8	PROPN
admet-193	122	11	)	)	PUNCT
admet-193	122	12	in	in	ADP
admet-193	122	13	the	the	DET
admet-193	122	14	set	set	NOUN
admet-193	122	15	are	be	AUX
admet-193	122	16	amiodarone	amiodarone	NOUN
admet-193	122	17	,	,	PUNCT
admet-193	122	18	cosalane	cosalane	NOUN
admet-193	122	19	,	,	PUNCT
admet-193	122	20	halofantrine	halofantrine	NOUN
admet-193	122	21	,	,	PUNCT
admet-193	122	22	clofazimine	clofazimine	ADJ
admet-193	122	23	,	,	PUNCT
admet-193	122	24	itraconazole	itraconazole	NOUN
admet-193	122	25	,	,	PUNCT
admet-193	122	26	quinclorac	quinclorac	PROPN
admet-193	122	27	,	,	PUNCT
admet-193	122	28	probucol	probucol	PROPN
admet-193	122	29	,	,	PUNCT
admet-193	122	30	brodifacoum	brodifacoum	NOUN
admet-193	122	31	,	,	PUNCT
admet-193	122	32	epristeride	epristeride	ADJ
admet-193	122	33	,	,	PUNCT
admet-193	122	34	silafluofen	silafluofen	NOUN
admet-193	122	35	,	,	PUNCT
admet-193	122	36	carbenoxolone	carbenoxolone	NOUN
admet-193	122	37	,	,	PUNCT
admet-193	122	38	tamoxifen	tamoxifen	NOUN
admet-193	122	39	,	,	PUNCT
admet-193	122	40	fluotrimazole	fluotrimazole	NOUN
admet-193	122	41	,	,	PUNCT
admet-193	122	42	moteretinide	moteretinide	ADJ
admet-193	122	43	,	,	PUNCT
admet-193	122	44	esfenvalerate	esfenvalerate	NOUN
admet-193	122	45	etofenprox	etofenprox	NOUN
admet-193	122	46	,	,	PUNCT
admet-193	122	47	etretinate	etretinate	NOUN
admet-193	122	48	,	,	PUNCT
admet-193	122	49	and	and	CCONJ
admet-193	122	50	npc-1161c	npc-1161c	NUM
admet-193	122	51	(	(	PUNCT
admet-193	122	52	which	which	PRON
admet-193	122	53	includes	include	VERB
admet-193	122	54	four	four	NUM
admet-193	122	55	agro	agro	ADJ
admet-193	122	56	-	-	PUNCT
admet-193	122	57	chemicals	chemical	NOUN
admet-193	122	58	)	)	PUNCT
admet-193	122	59	.	.	PUNCT
admet-193	123	1	the	the	DET
admet-193	123	2	most	most	ADV
admet-193	123	3	soluble	soluble	ADJ
admet-193	123	4	(	(	PUNCT
admet-193	123	5	log	log	NOUN
admet-193	123	6	s0	s0	PROPN
admet-193	123	7	>	>	X
admet-193	123	8	0	0	NUM
admet-193	123	9	)	)	PUNCT
admet-193	123	10	substances	substance	NOUN
admet-193	123	11	are	be	AUX
admet-193	123	12	amino	amino	ADJ
admet-193	123	13	acids	acid	NOUN
admet-193	123	14	,	,	PUNCT
admet-193	123	15	simple	simple	ADJ
admet-193	123	16	carboxylic	carboxylic	ADJ
admet-193	123	17	acids	acid	NOUN
admet-193	123	18	,	,	PUNCT
admet-193	123	19	and	and	CCONJ
admet-193	123	20	carbohydrates	carbohydrate	NOUN
admet-193	123	21	.	.	PUNCT
admet-193	124	1	the	the	DET
admet-193	124	2	compounds	compound	NOUN
admet-193	124	3	in	in	ADP
admet-193	124	4	the	the	DET
admet-193	124	5	4557	4557	NUM
admet-193	124	6	-	-	PUNCT
admet-193	124	7	set	set	VERB
admet-193	124	8	are	be	AUX
admet-193	124	9	solids	solid	NOUN
admet-193	124	10	at	at	ADP
admet-193	124	11	room	room	NOUN
admet-193	124	12	temperature	temperature	NOUN
admet-193	124	13	,	,	PUNCT
admet-193	124	14	with	with	ADP
admet-193	124	15	propofol	propofol	NOUN
admet-193	124	16	and	and	CCONJ
admet-193	124	17	nitroglycerin	nitroglycerin	NOUN
admet-193	124	18	at	at	ADP
admet-193	124	19	the	the	DET
admet-193	124	20	border	border	NOUN
admet-193	124	21	line	line	NOUN
admet-193	124	22	with	with	ADP
admet-193	124	23	the	the	DET
admet-193	124	24	melting	melting	NOUN
admet-193	124	25	points	point	NOUN
admet-193	124	26	19	19	NUM
admet-193	124	27	and	and	CCONJ
admet-193	124	28	14	14	NUM
admet-193	124	29	°	°	NOUN
admet-193	124	30	c	c	NOUN
admet-193	124	31	,	,	PUNCT
admet-193	124	32	respectively	respectively	ADV
admet-193	124	33	.	.	PUNCT
admet-193	125	1	the	the	DET
admet-193	125	2	shake	shake	NOUN
admet-193	125	3	-	-	PUNCT
admet-193	125	4	flask	flask	NOUN
admet-193	125	5	values	value	NOUN
admet-193	125	6	were	be	AUX
admet-193	125	7	mainly	mainly	ADV
admet-193	125	8	clustered	cluster	VERB
admet-193	125	9	around	around	ADP
admet-193	125	10	room	room	NOUN
admet-193	125	11	and	and	CCONJ
admet-193	125	12	physiological	physiological	ADJ
admet-193	125	13	temperatures	temperature	NOUN
admet-193	125	14	:	:	PUNCT
admet-193	125	15	23	23	NUM
admet-193	125	16	±	±	NUM
admet-193	125	17	3	3	NUM
admet-193	125	18	°	°	ADP
admet-193	125	19	c	c	X
admet-193	125	20	(	(	PUNCT
admet-193	125	21	78	78	NUM
admet-193	125	22	%	%	NOUN
admet-193	125	23	)	)	PUNCT
admet-193	125	24	and	and	CCONJ
admet-193	125	25	37	37	NUM
admet-193	125	26	±	±	NUM
admet-193	125	27	5	5	NUM
admet-193	125	28	°	°	ADP
admet-193	125	29	c	c	X
admet-193	125	30	(	(	PUNCT
admet-193	125	31	22	22	NUM
admet-193	125	32	%	%	NOUN
admet-193	125	33	)	)	PUNCT
admet-193	125	34	.	.	PUNCT
admet-193	126	1	figure	figure	NOUN
admet-193	126	2	1c	1c	NOUN
admet-193	126	3	shows	show	VERB
admet-193	126	4	the	the	DET
admet-193	126	5	temperature	temperature	NOUN
admet-193	126	6	frequency	frequency	NOUN
admet-193	126	7	distribution	distribution	NOUN
admet-193	126	8	.	.	PUNCT
admet-193	127	1	surprisingly	surprisingly	ADV
admet-193	127	2	,	,	PUNCT
admet-193	127	3	a	a	DET
admet-193	127	4	large	large	ADJ
admet-193	127	5	number	number	NOUN
admet-193	127	6	of	of	ADP
admet-193	127	7	sources	source	NOUN
admet-193	127	8	do	do	AUX
admet-193	127	9	n’t	not	PART
admet-193	127	10	state	state	VERB
admet-193	127	11	the	the	DET
admet-193	127	12	temperature	temperature	NOUN
admet-193	127	13	used	use	VERB
admet-193	127	14	in	in	ADP
admet-193	127	15	the	the	DET
admet-193	127	16	assay	assay	NOUN
admet-193	127	17	.	.	PUNCT
admet-193	128	1	contextually	contextually	ADV
admet-193	128	2	,	,	PUNCT
admet-193	128	3	room	room	NOUN
admet-193	128	4	temperature	temperature	NOUN
admet-193	128	5	is	be	AUX
admet-193	128	6	a	a	DET
admet-193	128	7	reasonable	reasonable	ADJ
admet-193	128	8	guess	guess	NOUN
admet-193	128	9	in	in	ADP
admet-193	128	10	most	most	ADJ
admet-193	128	11	instances	instance	NOUN
admet-193	128	12	.	.	PUNCT
admet-193	129	1	other	other	ADJ
admet-193	129	2	publications	publication	NOUN
admet-193	129	3	cite	cite	VERB
admet-193	129	4	“	"	PUNCT
admet-193	129	5	room	room	NOUN
admet-193	129	6	temperature	temperature	NOUN
admet-193	129	7	.	.	PUNCT
admet-193	129	8	”	"	PUNCT
admet-193	130	1	where	where	SCONJ
admet-193	130	2	the	the	DET
admet-193	130	3	precise	precise	ADJ
admet-193	130	4	temperature	temperature	NOUN
admet-193	130	5	was	be	AUX
admet-193	130	6	not	not	PART
admet-193	130	7	reported	report	VERB
admet-193	130	8	,	,	PUNCT
admet-193	130	9	it	it	PRON
admet-193	130	10	was	be	AUX
admet-193	130	11	taken	take	VERB
admet-193	130	12	to	to	PART
admet-193	130	13	be	be	AUX
admet-193	130	14	23	23	NUM
admet-193	130	15	°	°	ADP
admet-193	130	16	c	c	NOUN
admet-193	130	17	in	in	ADP
admet-193	130	18	the	the	DET
admet-193	130	19	assembled	assemble	VERB
admet-193	130	20	database	database	NOUN
admet-193	130	21	.	.	PUNCT
admet-193	131	1	figure	figure	NOUN
admet-193	131	2	2	2	NUM
admet-193	131	3	shows	show	VERB
admet-193	131	4	plots	plot	NOUN
admet-193	131	5	of	of	ADP
admet-193	131	6	six	six	NUM
admet-193	131	7	high	high	ADJ
admet-193	131	8	-	-	PUNCT
admet-193	131	9	quality	quality	NOUN
admet-193	131	10	examples	example	NOUN
admet-193	131	11	of	of	ADP
admet-193	131	12	multi	multi	ADJ
admet-193	131	13	-	-	ADJ
admet-193	131	14	ph	ph	ADJ
admet-193	131	15	solubility	solubility	NOUN
admet-193	131	16	data	datum	NOUN
admet-193	131	17	analyzed	analyze	VERB
admet-193	131	18	by	by	ADP
admet-193	131	19	pdisol	pdisol	NOUN
admet-193	131	20	-	-	PUNCT
admet-193	131	21	x.	x.	NOUN
admet-193	131	22	most	most	ADJ
admet-193	131	23	of	of	ADP
admet-193	131	24	the	the	DET
admet-193	131	25	compounds	compound	NOUN
admet-193	131	26	can	can	AUX
admet-193	131	27	be	be	AUX
admet-193	131	28	represented	represent	VERB
admet-193	131	29	by	by	ADP
admet-193	131	30	simple	simple	ADJ
admet-193	131	31	henderson	henderson	PROPN
admet-193	131	32	-	-	PUNCT
admet-193	131	33	hasselbalch	hasselbalch	PROPN
admet-193	131	34	equations	equation	NOUN
admet-193	131	35	(	(	PUNCT
admet-193	132	1	cf	cf	NOUN
admet-193	132	2	.	.	NOUN
admet-193	132	3	,	,	PUNCT
admet-193	132	4	below	below	ADP
admet-193	132	5	)	)	PUNCT
admet-193	132	6	.	.	PUNCT
admet-193	133	1	the	the	DET
admet-193	133	2	data	datum	NOUN
admet-193	133	3	from	from	ADP
admet-193	133	4	verapamil	verapamil	NOUN
admet-193	133	5	was	be	AUX
admet-193	133	6	best	well	ADV
admet-193	133	7	fit	fit	ADJ
admet-193	133	8	with	with	ADP
admet-193	133	9	a	a	DET
admet-193	133	10	tricationic	tricationic	ADJ
admet-193	133	11	aggregate	aggregate	NOUN
admet-193	133	12	below	below	ADP
admet-193	133	13	ph	ph	PROPN
admet-193	133	14	7	7	NUM
admet-193	133	15	.	.	NOUN
admet-193	133	16	above	above	ADP
admet-193	133	17	ph	ph	PROPN
admet-193	133	18	9	9	NUM
admet-193	133	19	the	the	DET
admet-193	133	20	free	free	ADJ
admet-193	133	21	-	-	PUNCT
admet-193	133	22	base	base	NOUN
admet-193	133	23	form	form	NOUN
admet-193	133	24	of	of	ADP
admet-193	133	25	verapamil	verapamil	NOUN
admet-193	133	26	may	may	AUX
admet-193	133	27	participate	participate	VERB
admet-193	133	28	in	in	ADP
admet-193	133	29	the	the	DET
admet-193	133	30	formation	formation	NOUN
admet-193	133	31	of	of	ADP
admet-193	133	32	uncharged	uncharged	ADJ
admet-193	133	33	water	water	NOUN
admet-193	133	34	-	-	PUNCT
admet-193	133	35	soluble	soluble	ADJ
admet-193	133	36	aggregates	aggregate	NOUN
admet-193	133	37	or	or	CCONJ
admet-193	133	38	micelle	micelle	NOUN
admet-193	133	39	-	-	PUNCT
admet-193	133	40	like	like	ADJ
admet-193	133	41	structures	structure	NOUN
admet-193	133	42	,	,	PUNCT
admet-193	133	43	consistent	consistent	ADJ
admet-193	133	44	with	with	ADP
admet-193	133	45	the	the	DET
admet-193	133	46	discussion	discussion	NOUN
admet-193	133	47	by	by	ADP
admet-193	133	48	surakitbanharn	surakitbanharn	NOUN
admet-193	133	49	et	et	PROPN
admet-193	133	50	al	al	PROPN
admet-193	133	51	.	.	PUNCT
admet-193	134	1	[	[	X
admet-193	134	2	51	51	NUM
admet-193	134	3	]	]	PUNCT
admet-193	134	4	.	.	PUNCT
admet-193	134	5	avdeef	avdeef	PROPN
admet-193	134	6	admet	admet	PROPN
admet-193	134	7	&	&	CCONJ
admet-193	134	8	dmpk	dmpk	PROPN
admet-193	134	9	3(2	3(2	NUM
admet-193	134	10	)	)	PUNCT
admet-193	134	11	(	(	PUNCT
admet-193	134	12	2015	2015	NUM
admet-193	134	13	)	)	PUNCT
admet-193	134	14	84	84	NUM
admet-193	134	15	-	-	SYM
admet-193	134	16	109	109	NUM
admet-193	134	17	88	88	NUM
admet-193	134	18	figure	figure	NOUN
admet-193	134	19	1	1	NUM
admet-193	134	20	.	.	PUNCT
admet-193	134	21	(	(	PUNCT
admet-193	134	22	a	a	X
admet-193	134	23	)	)	PUNCT
admet-193	134	24	distribution	distribution	NOUN
admet-193	134	25	of	of	ADP
admet-193	134	26	the	the	DET
admet-193	134	27	number	number	NOUN
admet-193	134	28	of	of	ADP
admet-193	134	29	multiple	multiple	ADJ
admet-193	134	30	-	-	PUNCT
admet-193	134	31	ph	ph	ADJ
admet-193	134	32	shake	shake	NOUN
admet-193	134	33	-	-	PUNCT
admet-193	134	34	flask	flask	NOUN
admet-193	134	35	measurements	measurement	NOUN
admet-193	134	36	per	per	ADP
admet-193	134	37	assay	assay	NOUN
admet-193	134	38	.	.	PUNCT
admet-193	135	1	(	(	PUNCT
admet-193	135	2	b	b	X
admet-193	135	3	)	)	PUNCT
admet-193	135	4	intrinsic	intrinsic	ADJ
admet-193	135	5	solubility	solubility	NOUN
admet-193	135	6	,	,	PUNCT
admet-193	135	7	log	log	NOUN
admet-193	135	8	s0	s0	NOUN
admet-193	135	9	,	,	PUNCT
admet-193	135	10	distribution	distribution	NOUN
admet-193	135	11	,	,	PUNCT
admet-193	135	12	as	as	ADP
admet-193	135	13	counts	count	NOUN
admet-193	135	14	in	in	ADP
admet-193	135	15	0.1	0.1	NUM
admet-193	135	16	log	log	NOUN
admet-193	135	17	unit	unit	NOUN
admet-193	135	18	intervals	interval	NOUN
admet-193	135	19	.	.	PUNCT
admet-193	136	1	(	(	PUNCT
admet-193	136	2	c	c	X
admet-193	136	3	)	)	PUNCT
admet-193	136	4	distribution	distribution	NOUN
admet-193	136	5	of	of	ADP
admet-193	136	6	assay	assay	ADJ
admet-193	136	7	temperature	temperature	NOUN
admet-193	136	8	in	in	ADP
admet-193	136	9	the	the	DET
admet-193	136	10	4557	4557	NUM
admet-193	136	11	-	-	PUNCT
admet-193	136	12	set	set	NOUN
admet-193	136	13	.	.	PUNCT
admet-193	137	1	on	on	ADP
admet-193	137	2	the	the	DET
admet-193	137	3	average	average	NOUN
admet-193	137	4	,	,	PUNCT
admet-193	137	5	log	log	NOUN
admet-193	137	6	s0	s0	NOUN
admet-193	137	7	increases	increase	NOUN
admet-193	137	8	by	by	ADP
admet-193	137	9	0.134	0.134	NUM
admet-193	137	10	log	log	NOUN
admet-193	137	11	unit	unit	NOUN
admet-193	137	12	as	as	SCONJ
admet-193	137	13	temperature	temperature	NOUN
admet-193	137	14	goes	go	VERB
admet-193	137	15	from	from	ADP
admet-193	137	16	25	25	NUM
admet-193	137	17	to	to	ADP
admet-193	137	18	37	37	NUM
admet-193	137	19	°	°	NOUN
admet-193	137	20	c	c	X
admet-193	137	21	.	.	PUNCT
admet-193	138	1	admet	admet	PROPN
admet-193	138	2	&	&	CCONJ
admet-193	138	3	dmpk	dmpk	PROPN
admet-193	138	4	3(2	3(2	NUM
admet-193	138	5	)	)	PUNCT
admet-193	138	6	(	(	PUNCT
admet-193	138	7	2015	2015	NUM
admet-193	138	8	)	)	PUNCT
admet-193	138	9	84	84	NUM
admet-193	138	10	-	-	SYM
admet-193	138	11	109	109	NUM
admet-193	138	12	equilibrium	equilibrium	NOUN
admet-193	138	13	solubility	solubility	NOUN
admet-193	138	14	measurements	measurement	NOUN
admet-193	138	15	improvements	improvement	NOUN
admet-193	138	16	doi	doi	NOUN
admet-193	138	17	:	:	PUNCT
admet-193	138	18	10.5599	10.5599	NUM
admet-193	138	19	/	/	SYM
admet-193	138	20	admet.3.2.193	admet.3.2.193	X
admet-193	138	21	89	89	NUM
admet-193	138	22	figure	figure	NOUN
admet-193	138	23	2	2	NUM
admet-193	138	24	.	.	PUNCT
admet-193	139	1	examples	example	NOUN
admet-193	139	2	of	of	ADP
admet-193	139	3	log	log	NOUN
admet-193	139	4	s	s	PART
admet-193	139	5	–	–	PUNCT
admet-193	139	6	ph	ph	ADJ
admet-193	139	7	profiles	profile	NOUN
admet-193	139	8	from	from	ADP
admet-193	139	9	well	well	ADV
admet-193	139	10	-	-	PUNCT
admet-193	139	11	designed	design	VERB
admet-193	139	12	assays	assay	NOUN
admet-193	139	13	for	for	ADP
admet-193	139	14	an	an	DET
admet-193	139	15	acid	acid	NOUN
admet-193	139	16	(	(	PUNCT
admet-193	139	17	flufenamic	flufenamic	ADJ
admet-193	139	18	acid	acid	NOUN
admet-193	139	19	)	)	PUNCT
admet-193	139	20	,	,	PUNCT
admet-193	139	21	three	three	NUM
admet-193	139	22	bases	basis	NOUN
admet-193	139	23	(	(	PUNCT
admet-193	139	24	oxycodone	oxycodone	NOUN
admet-193	139	25	,	,	PUNCT
admet-193	139	26	verapamil	verapamil	NOUN
admet-193	139	27	,	,	PUNCT
admet-193	139	28	and	and	CCONJ
admet-193	139	29	indinavir	indinavir	NOUN
admet-193	139	30	)	)	PUNCT
admet-193	139	31	,	,	PUNCT
admet-193	139	32	and	and	CCONJ
admet-193	139	33	two	two	NUM
admet-193	139	34	ampholytes	ampholyte	NOUN
admet-193	139	35	(	(	PUNCT
admet-193	139	36	dorzolamide	dorzolamide	NOUN
admet-193	139	37	and	and	CCONJ
admet-193	139	38	tyrosine	tyrosine	NOUN
admet-193	139	39	)	)	PUNCT
admet-193	139	40	.	.	PUNCT
admet-193	140	1	note	note	VERB
admet-193	140	2	that	that	SCONJ
admet-193	140	3	the	the	DET
admet-193	140	4	tyrosine	tyrosine	NOUN
admet-193	140	5	is	be	AUX
admet-193	140	6	based	base	VERB
admet-193	140	7	on	on	ADP
admet-193	140	8	measurements	measurement	NOUN
admet-193	140	9	done	do	VERB
admet-193	140	10	in	in	ADP
admet-193	140	11	1924	1924	NUM
admet-193	140	12	.	.	PUNCT
admet-193	141	1	the	the	DET
admet-193	141	2	solid	solid	ADJ
admet-193	141	3	(	(	PUNCT
admet-193	141	4	red	red	ADJ
admet-193	141	5	)	)	PUNCT
admet-193	141	6	curves	curve	NOUN
admet-193	141	7	represent	represent	VERB
admet-193	141	8	the	the	DET
admet-193	141	9	best	good	ADJ
admet-193	141	10	-	-	PUNCT
admet-193	141	11	fit	fit	ADJ
admet-193	141	12	pdisol	pdisol	ADJ
admet-193	141	13	-	-	PUNCT
admet-193	141	14	x	x	NOUN
admet-193	141	15	model	model	NOUN
admet-193	141	16	which	which	PRON
admet-193	141	17	rationalizes	rationalize	VERB
admet-193	141	18	the	the	DET
admet-193	141	19	measured	measured	ADJ
admet-193	141	20	solubility	solubility	NOUN
admet-193	141	21	values	value	NOUN
admet-193	141	22	(	(	PUNCT
admet-193	141	23	filled	fill	VERB
admet-193	141	24	circle	circle	NOUN
admet-193	141	25	symbols	symbol	NOUN
admet-193	141	26	)	)	PUNCT
admet-193	141	27	.	.	PUNCT
admet-193	142	1	the	the	DET
admet-193	142	2	dotted	dot	VERB
admet-193	142	3	curves	curve	NOUN
admet-193	142	4	depict	depict	VERB
admet-193	142	5	the	the	DET
admet-193	142	6	ph	ph	ADJ
admet-193	142	7	interval	interval	NOUN
admet-193	142	8	where	where	SCONJ
admet-193	142	9	the	the	DET
admet-193	142	10	compounds	compound	NOUN
admet-193	142	11	were	be	AUX
admet-193	142	12	fully	fully	ADV
admet-193	142	13	-	-	PUNCT
admet-193	142	14	dissolved	dissolve	VERB
admet-193	142	15	.	.	PUNCT
admet-193	143	1	the	the	DET
admet-193	143	2	dashed	dash	VERB
admet-193	143	3	curves	curve	NOUN
admet-193	143	4	were	be	AUX
admet-193	143	5	calculated	calculate	VERB
admet-193	143	6	from	from	ADP
admet-193	143	7	the	the	DET
admet-193	143	8	hendersonhasselbalch	hendersonhasselbalch	PROPN
admet-193	143	9	equations	equation	NOUN
admet-193	143	10	.	.	PUNCT
admet-193	144	1	flufenamic	flufenamic	ADJ
admet-193	144	2	acid	acid	NOUN
admet-193	144	3	,	,	PUNCT
admet-193	144	4	oxycodone	oxycodone	NOUN
admet-193	144	5	,	,	PUNCT
admet-193	144	6	and	and	CCONJ
admet-193	144	7	dorzolamide	dorzolamide	NOUN
admet-193	144	8	were	be	AUX
admet-193	144	9	studied	study	VERB
admet-193	144	10	at	at	ADP
admet-193	144	11	concentrations	concentration	NOUN
admet-193	144	12	high	high	ADJ
admet-193	144	13	enough	enough	ADV
admet-193	144	14	to	to	PART
admet-193	144	15	effect	effect	VERB
admet-193	144	16	salt	salt	NOUN
admet-193	144	17	precipitation	precipitation	NOUN
admet-193	144	18	.	.	PUNCT
admet-193	145	1	in	in	ADP
admet-193	145	2	all	all	DET
admet-193	145	3	cases	case	NOUN
admet-193	145	4	but	but	CCONJ
admet-193	145	5	verapamil	verapamil	NOUN
admet-193	145	6	,	,	PUNCT
admet-193	145	7	it	it	PRON
admet-193	145	8	was	be	AUX
admet-193	145	9	possible	possible	ADJ
admet-193	145	10	to	to	PART
admet-193	145	11	refine	refine	VERB
admet-193	145	12	the	the	DET
admet-193	145	13	pka	pka	PROPN
admet-193	145	14	values	value	NOUN
admet-193	145	15	.	.	PUNCT
admet-193	146	1	verapamil	verapamil	NOUN
admet-193	146	2	and	and	CCONJ
admet-193	146	3	flufenamic	flufenamic	PROPN
admet-193	146	4	acid	acid	NOUN
admet-193	146	5	show	show	VERB
admet-193	146	6	some	some	DET
admet-193	146	7	evidence	evidence	NOUN
admet-193	146	8	of	of	ADP
admet-193	146	9	formation	formation	NOUN
admet-193	146	10	of	of	ADP
admet-193	146	11	aggregates	aggregate	NOUN
admet-193	146	12	.	.	PUNCT
admet-193	147	1	avdeef	avdeef	PROPN
admet-193	147	2	admet	admet	PROPN
admet-193	147	3	&	&	CCONJ
admet-193	147	4	dmpk	dmpk	PROPN
admet-193	147	5	3(2	3(2	NUM
admet-193	147	6	)	)	PUNCT
admet-193	147	7	(	(	PUNCT
admet-193	147	8	2015	2015	NUM
admet-193	147	9	)	)	PUNCT
admet-193	147	10	84	84	NUM
admet-193	147	11	-	-	SYM
admet-193	147	12	109	109	NUM
admet-193	147	13	90	90	NUM
admet-193	147	14	results	result	NOUN
admet-193	147	15	and	and	CCONJ
admet-193	147	16	discussion	discussion	NOUN
admet-193	147	17	solubility	solubility	NOUN
admet-193	147	18	units	unit	NOUN
admet-193	147	19	and	and	CCONJ
admet-193	147	20	conversion	conversion	NOUN
admet-193	147	21	issues	issue	NOUN
admet-193	147	22	solubility	solubility	NOUN
admet-193	147	23	measurements	measurement	NOUN
admet-193	147	24	have	have	AUX
admet-193	147	25	been	be	AUX
admet-193	147	26	reported	report	VERB
admet-193	147	27	in	in	ADP
admet-193	147	28	a	a	DET
admet-193	147	29	multiplicity	multiplicity	NOUN
admet-193	147	30	of	of	ADP
admet-193	147	31	concentration	concentration	NOUN
admet-193	147	32	units	unit	NOUN
admet-193	147	33	:	:	PUNCT
admet-193	147	34	mol	mol	PROPN
admet-193	147	35	/	/	SYM
admet-193	147	36	l	l	NOUN
admet-193	147	37	(	(	PUNCT
admet-193	147	38	molarity	molarity	NOUN
admet-193	147	39	,	,	PUNCT
admet-193	147	40	m	m	PROPN
admet-193	147	41	)	)	PUNCT
admet-193	147	42	,	,	PUNCT
admet-193	147	43	mm	mm	PROPN
admet-193	147	44	,	,	PUNCT
admet-193	147	45	μm	μm	INTJ
admet-193	147	46	,	,	PUNCT
admet-193	147	47	mol	mol	PROPN
admet-193	147	48	/	/	SYM
admet-193	147	49	kg	kg	PROPN
admet-193	147	50	(	(	PUNCT
admet-193	147	51	molality	molality	NOUN
admet-193	147	52	,	,	PUNCT
admet-193	147	53	m	m	PROPN
admet-193	147	54	)	)	PUNCT
admet-193	147	55	,	,	PUNCT
admet-193	147	56	mole	mole	NOUN
admet-193	147	57	fraction	fraction	NOUN
admet-193	147	58	,	,	PUNCT
admet-193	147	59	mass	mass	NOUN
admet-193	147	60	fraction	fraction	NOUN
admet-193	147	61	,	,	PUNCT
admet-193	147	62	weight	weight	NOUN
admet-193	147	63	/	/	SYM
admet-193	147	64	ml	ml	NOUN
admet-193	147	65	(	(	PUNCT
admet-193	147	66	e.g.	e.g.	ADV
admet-193	147	67	,	,	PUNCT
admet-193	147	68	mg	mg	PROPN
admet-193	147	69	/	/	SYM
admet-193	147	70	ml	ml	PROPN
admet-193	147	71	,	,	PUNCT
admet-193	147	72	μg	μg	PROPN
admet-193	147	73	/	/	SYM
admet-193	147	74	ml	ml	PROPN
admet-193	147	75	,	,	PUNCT
admet-193	147	76	ng	ng	PROPN
admet-193	147	77	/	/	SYM
admet-193	147	78	ml	ml	PROPN
admet-193	147	79	,	,	PUNCT
admet-193	147	80	pg	pg	NOUN
admet-193	147	81	/	/	SYM
admet-193	147	82	ml	ml	NOUN
admet-193	147	83	…	…	PUNCT
admet-193	147	84	)	)	PUNCT
admet-193	147	85	,	,	PUNCT
admet-193	147	86	mg/100	mg/100	NOUN
admet-193	147	87	ml	ml	NOUN
admet-193	147	88	,	,	PUNCT
admet-193	147	89	mg	mg	PROPN
admet-193	147	90	/	/	SYM
admet-193	147	91	dl	dl	PROPN
admet-193	147	92	,	,	PUNCT
admet-193	147	93	%	%	INTJ
admet-193	147	94	w	w	PROPN
admet-193	147	95	/	/	SYM
admet-193	147	96	v	v	NOUN
admet-193	147	97	,	,	PUNCT
admet-193	147	98	g%ml	g%ml	NOUN
admet-193	147	99	,	,	PUNCT
admet-193	147	100	mg	mg	PROPN
admet-193	147	101	/	/	SYM
admet-193	147	102	ml%	ml%	PROPN
admet-193	147	103	,	,	PUNCT
admet-193	147	104	mg%	mg%	NOUN
admet-193	147	105	,	,	PUNCT
admet-193	147	106	“	"	PUNCT
admet-193	147	107	1	1	NUM
admet-193	147	108	in	in	ADP
admet-193	147	109	40	40	NUM
admet-193	147	110	of	of	ADP
admet-193	147	111	water	water	NOUN
admet-193	147	112	,	,	PUNCT
admet-193	147	113	”	"	PUNCT
admet-193	147	114	“	"	PUNCT
admet-193	147	115	soluble	soluble	ADJ
admet-193	147	116	in	in	ADP
admet-193	147	117	2	2	NUM
admet-193	147	118	parts	part	NOUN
admet-193	147	119	of	of	ADP
admet-193	147	120	water	water	NOUN
admet-193	147	121	,	,	PUNCT
admet-193	147	122	”	"	PUNCT
admet-193	147	123	“	"	PUNCT
admet-193	147	124	3	3	NUM
admet-193	147	125	%	%	NOUN
admet-193	147	126	soluble	soluble	ADJ
admet-193	147	127	in	in	ADP
admet-193	147	128	water	water	NOUN
admet-193	147	129	,	,	PUNCT
admet-193	147	130	”	"	PUNCT
admet-193	147	131	units	unit	NOUN
admet-193	147	132	of	of	ADP
admet-193	147	133	iu	iu	ADP
admet-193	147	134	/	/	SYM
admet-193	147	135	ml	ml	NOUN
admet-193	147	136	,	,	PUNCT
admet-193	147	137	etc	etc	X
admet-193	147	138	.	.	X
admet-193	147	139	mole	mole	NOUN
admet-193	147	140	fraction	fraction	NOUN
admet-193	147	141	,	,	PUNCT
admet-193	147	142	mass	mass	NOUN
admet-193	147	143	fraction	fraction	NOUN
admet-193	147	144	,	,	PUNCT
admet-193	147	145	and	and	CCONJ
admet-193	147	146	molality	molality	NOUN
admet-193	147	147	units	unit	NOUN
admet-193	147	148	are	be	AUX
admet-193	147	149	almost	almost	ADV
admet-193	147	150	always	always	ADV
admet-193	147	151	used	use	VERB
admet-193	147	152	when	when	SCONJ
admet-193	147	153	solubility	solubility	NOUN
admet-193	147	154	is	be	AUX
admet-193	147	155	determined	determine	VERB
admet-193	147	156	over	over	ADP
admet-193	147	157	a	a	DET
admet-193	147	158	wide	wide	ADJ
admet-193	147	159	range	range	NOUN
admet-193	147	160	of	of	ADP
admet-193	147	161	temperatures	temperature	NOUN
admet-193	147	162	,	,	PUNCT
admet-193	147	163	since	since	SCONJ
admet-193	147	164	the	the	DET
admet-193	147	165	units	unit	NOUN
admet-193	147	166	do	do	AUX
admet-193	147	167	not	not	PART
admet-193	147	168	depend	depend	VERB
admet-193	147	169	on	on	ADP
admet-193	147	170	the	the	DET
admet-193	147	171	density	density	NOUN
admet-193	147	172	of	of	ADP
admet-193	147	173	the	the	DET
admet-193	147	174	solutions	solution	NOUN
admet-193	147	175	.	.	PUNCT
admet-193	148	1	it	it	PRON
admet-193	148	2	is	be	AUX
admet-193	148	3	not	not	PART
admet-193	148	4	clear	clear	ADJ
admet-193	148	5	why	why	SCONJ
admet-193	148	6	units	unit	NOUN
admet-193	148	7	such	such	ADJ
admet-193	148	8	as	as	ADP
admet-193	148	9	mg%	mg%	NOUN
admet-193	148	10	would	would	AUX
admet-193	148	11	be	be	AUX
admet-193	148	12	preferred	prefer	VERB
admet-193	148	13	.	.	PUNCT
admet-193	149	1	in	in	ADP
admet-193	149	2	certain	certain	ADJ
admet-193	149	3	publications	publication	NOUN
admet-193	149	4	such	such	ADJ
admet-193	149	5	units	unit	NOUN
admet-193	149	6	are	be	AUX
admet-193	149	7	not	not	PART
admet-193	149	8	explicitly	explicitly	ADV
admet-193	149	9	defined	define	VERB
admet-193	149	10	.	.	PUNCT
admet-193	150	1	usually	usually	ADV
admet-193	150	2	(	(	PUNCT
admet-193	150	3	but	but	CCONJ
admet-193	150	4	not	not	PART
admet-193	150	5	always	always	ADV
admet-193	150	6	)	)	PUNCT
admet-193	150	7	,	,	PUNCT
admet-193	150	8	mol	mol	ADP
admet-193	150	9	fractions	fraction	NOUN
admet-193	150	10	are	be	AUX
admet-193	150	11	precisely	precisely	ADV
admet-193	150	12	defined	define	VERB
admet-193	150	13	in	in	ADP
admet-193	150	14	the	the	DET
admet-193	150	15	publication	publication	NOUN
admet-193	150	16	,	,	PUNCT
admet-193	150	17	so	so	SCONJ
admet-193	150	18	that	that	SCONJ
admet-193	150	19	conversion	conversion	NOUN
admet-193	150	20	to	to	ADP
admet-193	150	21	molarity	molarity	NOUN
admet-193	150	22	is	be	AUX
admet-193	150	23	straight	straight	ADV
admet-193	150	24	forward	forward	ADV
admet-193	150	25	if	if	SCONJ
admet-193	150	26	the	the	DET
admet-193	150	27	solution	solution	NOUN
admet-193	150	28	density	density	NOUN
admet-193	150	29	is	be	AUX
admet-193	150	30	known	know	VERB
admet-193	150	31	(	(	PUNCT
admet-193	150	32	which	which	PRON
admet-193	150	33	is	be	AUX
admet-193	150	34	slightly	slightly	ADV
admet-193	150	35	higher	high	ADJ
admet-193	150	36	than	than	ADP
admet-193	150	37	that	that	PRON
admet-193	150	38	of	of	ADP
admet-193	150	39	pure	pure	ADJ
admet-193	150	40	water	water	NOUN
admet-193	150	41	)	)	PUNCT
admet-193	150	42	.	.	PUNCT
admet-193	151	1	the	the	DET
admet-193	151	2	same	same	ADJ
admet-193	151	3	can	can	AUX
admet-193	151	4	not	not	PART
admet-193	151	5	be	be	AUX
admet-193	151	6	said	say	VERB
admet-193	151	7	of	of	ADP
admet-193	151	8	the	the	DET
admet-193	151	9	very	very	ADV
admet-193	151	10	frequently	frequently	ADV
admet-193	151	11	used	use	VERB
admet-193	151	12	weight	weight	NOUN
admet-193	151	13	/	/	SYM
admet-193	151	14	ml	ml	VERB
admet-193	151	15	“	"	PUNCT
admet-193	151	16	practical	practical	ADJ
admet-193	151	17	”	"	PUNCT
admet-193	151	18	units	unit	NOUN
admet-193	151	19	.	.	PUNCT
admet-193	152	1	in	in	ADP
admet-193	152	2	the	the	DET
admet-193	152	3	clearly	clearly	ADV
admet-193	152	4	presented	present	VERB
admet-193	152	5	papers	paper	NOUN
admet-193	152	6	,	,	PUNCT
admet-193	152	7	the	the	DET
admet-193	152	8	equivalent	equivalent	ADJ
admet-193	152	9	molecular	molecular	ADJ
admet-193	152	10	weight	weight	NOUN
admet-193	152	11	to	to	PART
admet-193	152	12	use	use	VERB
admet-193	152	13	to	to	PART
admet-193	152	14	convert	convert	VERB
admet-193	152	15	the	the	DET
admet-193	152	16	practical	practical	ADJ
admet-193	152	17	values	value	NOUN
admet-193	152	18	to	to	ADP
admet-193	152	19	molarity	molarity	NOUN
admet-193	152	20	is	be	AUX
admet-193	152	21	stated	state	VERB
admet-193	152	22	(	(	PUNCT
admet-193	152	23	e.g.	e.g.	ADV
admet-193	152	24	,	,	PUNCT
admet-193	152	25	“	"	PUNCT
admet-193	152	26	concentration	concentration	NOUN
admet-193	152	27	is	be	AUX
admet-193	152	28	expressed	express	VERB
admet-193	152	29	as	as	ADP
admet-193	152	30	free	free	ADJ
admet-193	152	31	base	base	NOUN
admet-193	152	32	equivalent	equivalent	NOUN
admet-193	152	33	”	"	PUNCT
admet-193	152	34	)	)	PUNCT
admet-193	152	35	or	or	CCONJ
admet-193	152	36	is	be	AUX
admet-193	152	37	evident	evident	ADJ
admet-193	152	38	,	,	PUNCT
admet-193	152	39	but	but	CCONJ
admet-193	152	40	too	too	ADV
admet-193	152	41	often	often	ADV
admet-193	152	42	,	,	PUNCT
admet-193	152	43	the	the	DET
admet-193	152	44	reader	reader	NOUN
admet-193	152	45	has	have	VERB
admet-193	152	46	to	to	PART
admet-193	152	47	guess	guess	VERB
admet-193	152	48	what	what	PRON
admet-193	152	49	the	the	DET
admet-193	152	50	authors	author	NOUN
admet-193	152	51	intended	intend	VERB
admet-193	152	52	.	.	PUNCT
admet-193	153	1	for	for	ADP
admet-193	153	2	a	a	DET
admet-193	153	3	given	give	VERB
admet-193	153	4	molecule	molecule	NOUN
admet-193	153	5	,	,	PUNCT
admet-193	153	6	often	often	ADV
admet-193	153	7	the	the	DET
admet-193	153	8	uncertain	uncertain	ADJ
admet-193	153	9	units	unit	NOUN
admet-193	153	10	became	become	VERB
admet-193	153	11	evident	evident	ADJ
admet-193	153	12	when	when	SCONJ
admet-193	153	13	compared	compare	VERB
admet-193	153	14	to	to	ADP
admet-193	153	15	results	result	NOUN
admet-193	153	16	from	from	ADP
admet-193	153	17	different	different	ADJ
admet-193	153	18	publications	publication	NOUN
admet-193	153	19	.	.	PUNCT
admet-193	154	1	as	as	SCONJ
admet-193	154	2	different	different	ADJ
admet-193	154	3	units	unit	NOUN
admet-193	154	4	are	be	AUX
admet-193	154	5	in	in	ADP
admet-193	154	6	common	common	ADJ
admet-193	154	7	usage	usage	NOUN
admet-193	154	8	,	,	PUNCT
admet-193	154	9	consequently	consequently	ADV
admet-193	154	10	a	a	DET
admet-193	154	11	useful	useful	ADJ
admet-193	154	12	sense	sense	NOUN
admet-193	154	13	of	of	ADP
admet-193	154	14	comparisons	comparison	NOUN
admet-193	154	15	between	between	ADP
admet-193	154	16	different	different	ADJ
admet-193	154	17	studies	study	NOUN
admet-193	154	18	is	be	AUX
admet-193	154	19	a	a	DET
admet-193	154	20	challenge	challenge	NOUN
admet-193	154	21	.	.	PUNCT
admet-193	155	1	on	on	ADP
admet-193	155	2	a	a	DET
admet-193	155	3	practical	practical	ADJ
admet-193	155	4	note	note	NOUN
admet-193	155	5	,	,	PUNCT
admet-193	155	6	it	it	PRON
admet-193	155	7	is	be	AUX
admet-193	155	8	all	all	ADV
admet-193	155	9	too	too	ADV
admet-193	155	10	easy	easy	ADJ
admet-193	155	11	to	to	PART
admet-193	155	12	make	make	VERB
admet-193	155	13	a	a	DET
admet-193	155	14	mistake	mistake	NOUN
admet-193	155	15	in	in	ADP
admet-193	155	16	converting	convert	VERB
admet-193	155	17	the	the	DET
admet-193	155	18	units	unit	NOUN
admet-193	155	19	to	to	ADP
admet-193	155	20	the	the	DET
admet-193	155	21	preferred	preferred	ADJ
admet-193	155	22	molarity	molarity	NOUN
admet-193	155	23	scale	scale	NOUN
admet-193	155	24	of	of	ADP
admet-193	155	25	the	the	DET
admet-193	155	26	database	database	NOUN
admet-193	155	27	.	.	PUNCT
admet-193	156	1	it	it	PRON
admet-193	156	2	could	could	AUX
admet-193	156	3	be	be	AUX
admet-193	156	4	argued	argue	VERB
admet-193	156	5	that	that	SCONJ
admet-193	156	6	solubility	solubility	NOUN
admet-193	156	7	should	should	AUX
admet-193	156	8	be	be	AUX
admet-193	156	9	presented	present	VERB
admet-193	156	10	in	in	ADP
admet-193	156	11	log	log	NOUN
admet-193	156	12	units	unit	NOUN
admet-193	156	13	(	(	PUNCT
admet-193	156	14	preferably	preferably	ADV
admet-193	156	15	based	base	VERB
admet-193	156	16	on	on	ADP
admet-193	156	17	molarity	molarity	NOUN
admet-193	156	18	)	)	PUNCT
admet-193	156	19	,	,	PUNCT
admet-193	156	20	since	since	SCONJ
admet-193	156	21	(	(	PUNCT
admet-193	156	22	a	a	X
admet-193	156	23	)	)	PUNCT
admet-193	156	24	direct	direct	ADJ
admet-193	156	25	values	value	NOUN
admet-193	156	26	span	span	VERB
admet-193	156	27	over	over	ADP
admet-193	156	28	12	12	NUM
admet-193	156	29	orders	order	NOUN
admet-193	156	30	of	of	ADP
admet-193	156	31	magnitude	magnitude	NOUN
admet-193	156	32	and	and	CCONJ
admet-193	156	33	can	can	AUX
admet-193	156	34	not	not	PART
admet-193	156	35	be	be	AUX
admet-193	156	36	accurately	accurately	ADV
admet-193	156	37	depicted	depict	VERB
admet-193	156	38	in	in	ADP
admet-193	156	39	s	s	ADJ
admet-193	156	40	-	-	PUNCT
admet-193	156	41	ph	ph	ADJ
admet-193	156	42	plots	plot	NOUN
admet-193	156	43	at	at	ADP
admet-193	156	44	the	the	DET
admet-193	156	45	low	low	ADJ
admet-193	156	46	end	end	NOUN
admet-193	156	47	of	of	ADP
admet-193	156	48	the	the	DET
admet-193	156	49	scale	scale	NOUN
admet-193	156	50	,	,	PUNCT
admet-193	156	51	and	and	CCONJ
admet-193	156	52	(	(	PUNCT
admet-193	156	53	b	b	X
admet-193	156	54	)	)	PUNCT
admet-193	156	55	since	since	SCONJ
admet-193	156	56	errors	error	NOUN
admet-193	156	57	in	in	ADP
admet-193	156	58	log	log	NOUN
admet-193	156	59	values	value	NOUN
admet-193	156	60	do	do	AUX
admet-193	156	61	not	not	PART
admet-193	156	62	depend	depend	VERB
admet-193	156	63	on	on	ADP
admet-193	156	64	the	the	DET
admet-193	156	65	magnitude	magnitude	NOUN
admet-193	156	66	of	of	ADP
admet-193	156	67	the	the	DET
admet-193	156	68	log	log	NOUN
admet-193	156	69	solubility	solubility	NOUN
admet-193	156	70	(	(	PUNCT
admet-193	156	71	whereas	whereas	SCONJ
admet-193	156	72	they	they	PRON
admet-193	156	73	do	do	VERB
admet-193	156	74	when	when	SCONJ
admet-193	156	75	direct	direct	ADJ
admet-193	156	76	units	unit	NOUN
admet-193	156	77	are	be	AUX
admet-193	156	78	considered	consider	VERB
admet-193	156	79	)	)	PUNCT
admet-193	156	80	.	.	PUNCT
admet-193	157	1	for	for	ADP
admet-193	157	2	example	example	NOUN
admet-193	157	3	,	,	PUNCT
admet-193	157	4	it	it	PRON
admet-193	157	5	should	should	AUX
admet-193	157	6	be	be	AUX
admet-193	157	7	possible	possible	ADJ
admet-193	157	8	to	to	PART
admet-193	157	9	claim	claim	VERB
admet-193	157	10	that	that	SCONJ
admet-193	157	11	shake	shake	NOUN
admet-193	157	12	-	-	PUNCT
admet-193	157	13	flask	flask	NOUN
admet-193	157	14	log	log	NOUN
admet-193	157	15	s	s	NOUN
admet-193	157	16	values	value	NOUN
admet-193	157	17	have	have	VERB
admet-193	157	18	an	an	DET
admet-193	157	19	average	average	ADJ
admet-193	157	20	reproducibility	reproducibility	NOUN
admet-193	157	21	of	of	ADP
admet-193	157	22	0.1	0.1	NUM
admet-193	157	23	log	log	NOUN
admet-193	157	24	unit	unit	NOUN
admet-193	157	25	for	for	ADP
admet-193	157	26	a	a	DET
admet-193	157	27	given	give	VERB
admet-193	157	28	molecule	molecule	NOUN
admet-193	157	29	between	between	ADP
admet-193	157	30	values	value	NOUN
admet-193	157	31	reported	report	VERB
admet-193	157	32	in	in	ADP
admet-193	157	33	different	different	ADJ
admet-193	157	34	publications	publication	NOUN
admet-193	157	35	;	;	PUNCT
admet-193	157	36	it	it	PRON
admet-193	157	37	makes	make	VERB
admet-193	157	38	no	no	DET
admet-193	157	39	obvious	obvious	ADJ
admet-193	157	40	sense	sense	NOUN
admet-193	157	41	to	to	PART
admet-193	157	42	present	present	VERB
admet-193	157	43	an	an	DET
admet-193	157	44	average	average	ADJ
admet-193	157	45	reproducibility	reproducibility	NOUN
admet-193	157	46	value	value	NOUN
admet-193	157	47	of	of	ADP
admet-193	157	48	s	s	NOUN
admet-193	157	49	measurements	measurement	NOUN
admet-193	157	50	that	that	PRON
admet-193	157	51	can	can	AUX
admet-193	157	52	span	span	VERB
admet-193	157	53	so	so	ADV
admet-193	157	54	many	many	ADJ
admet-193	157	55	orders	order	NOUN
admet-193	157	56	of	of	ADP
admet-193	157	57	magnitude	magnitude	NOUN
admet-193	157	58	.	.	PUNCT
admet-193	158	1	in	in	ADP
admet-193	158	2	the	the	DET
admet-193	158	3	4557	4557	NUM
admet-193	158	4	-	-	PUNCT
admet-193	158	5	set	set	VERB
admet-193	158	6	database	database	NOUN
admet-193	158	7	,	,	PUNCT
admet-193	158	8	values	value	NOUN
admet-193	158	9	reported	report	VERB
admet-193	158	10	in	in	ADP
admet-193	158	11	molality	molality	NOUN
admet-193	158	12	units	unit	NOUN
admet-193	158	13	were	be	AUX
admet-193	158	14	noted	note	VERB
admet-193	158	15	,	,	PUNCT
admet-193	158	16	but	but	CCONJ
admet-193	158	17	not	not	PART
admet-193	158	18	converted	convert	VERB
admet-193	158	19	to	to	ADP
admet-193	158	20	those	those	PRON
admet-193	158	21	in	in	ADP
admet-193	158	22	molarity	molarity	NOUN
admet-193	158	23	(	(	PUNCT
admet-193	158	24	by	by	ADP
admet-193	158	25	correcting	correct	VERB
admet-193	158	26	for	for	ADP
admet-193	158	27	density	density	NOUN
admet-193	158	28	)	)	PUNCT
admet-193	158	29	,	,	PUNCT
admet-193	158	30	since	since	SCONJ
admet-193	158	31	the	the	DET
admet-193	158	32	differences	difference	NOUN
admet-193	158	33	are	be	AUX
admet-193	158	34	small	small	ADJ
admet-193	158	35	near	near	ADP
admet-193	158	36	the	the	DET
admet-193	158	37	temperature	temperature	NOUN
admet-193	158	38	range	range	NOUN
admet-193	158	39	of	of	ADP
admet-193	158	40	interest	interest	NOUN
admet-193	158	41	(	(	PUNCT
admet-193	158	42	20	20	NUM
admet-193	158	43	-	-	SYM
admet-193	158	44	40	40	NUM
admet-193	158	45	°	°	NOUN
admet-193	158	46	c	c	NOUN
admet-193	158	47	)	)	PUNCT
admet-193	158	48	,	,	PUNCT
admet-193	158	49	and	and	CCONJ
admet-193	158	50	the	the	PRON
admet-193	158	51	since	since	SCONJ
admet-193	158	52	the	the	DET
admet-193	158	53	actual	actual	ADJ
admet-193	158	54	solution	solution	NOUN
admet-193	158	55	density	density	NOUN
admet-193	158	56	is	be	AUX
admet-193	158	57	seldom	seldom	ADV
admet-193	158	58	reported	report	VERB
admet-193	158	59	.	.	PUNCT
admet-193	159	1	impact	impact	NOUN
admet-193	159	2	of	of	ADP
admet-193	159	3	accuracy	accuracy	NOUN
admet-193	159	4	in	in	ADP
admet-193	159	5	the	the	DET
admet-193	159	6	type	type	NOUN
admet-193	159	7	of	of	ADP
admet-193	159	8	data	datum	NOUN
admet-193	159	9	used	use	VERB
admet-193	159	10	for	for	ADP
admet-193	159	11	prediction	prediction	NOUN
admet-193	159	12	training	training	NOUN
admet-193	159	13	sets	set	NOUN
admet-193	159	14	most	most	ADJ
admet-193	159	15	studies	study	NOUN
admet-193	159	16	aimed	aim	VERB
admet-193	159	17	to	to	PART
admet-193	159	18	predict	predict	VERB
admet-193	159	19	s0	s0	PROPN
admet-193	159	20	values	value	NOUN
admet-193	159	21	,	,	PUNCT
admet-193	159	22	whether	whether	SCONJ
admet-193	159	23	explicitly	explicitly	ADV
admet-193	159	24	stated	state	VERB
admet-193	159	25	or	or	CCONJ
admet-193	159	26	not	not	PART
admet-193	159	27	.	.	PUNCT
admet-193	160	1	however	however	ADV
admet-193	160	2	,	,	PUNCT
admet-193	160	3	most	most	ADJ
admet-193	160	4	studies	study	NOUN
admet-193	160	5	used	use	VERB
admet-193	160	6	sw	sw	PROPN
admet-193	160	7	values	value	NOUN
admet-193	160	8	in	in	ADP
admet-193	160	9	the	the	DET
admet-193	160	10	training	training	NOUN
admet-193	160	11	sets	set	NOUN
admet-193	160	12	,	,	PUNCT
admet-193	160	13	which	which	PRON
admet-193	160	14	resulted	result	VERB
admet-193	160	15	in	in	ADP
admet-193	160	16	increased	increase	VERB
admet-193	160	17	errors	error	NOUN
admet-193	160	18	for	for	ADP
admet-193	160	19	low	low	ADJ
admet-193	160	20	soluble	soluble	ADJ
admet-193	160	21	ionizable	ionizable	ADJ
admet-193	160	22	molecules	molecule	NOUN
admet-193	160	23	.	.	PUNCT
admet-193	161	1	the	the	DET
admet-193	161	2	exception	exception	NOUN
admet-193	161	3	is	be	AUX
admet-193	161	4	with	with	ADP
admet-193	161	5	nonionizable	nonionizable	ADJ
admet-193	161	6	molecules	molecule	NOUN
admet-193	161	7	,	,	PUNCT
admet-193	161	8	where	where	SCONJ
admet-193	161	9	water	water	NOUN
admet-193	161	10	and	and	CCONJ
admet-193	161	11	intrinsic	intrinsic	ADJ
admet-193	161	12	solubility	solubility	NOUN
admet-193	161	13	are	be	AUX
admet-193	161	14	the	the	DET
admet-193	161	15	same	same	ADJ
admet-193	161	16	:	:	PUNCT
admet-193	161	17	sw	sw	PROPN
admet-193	161	18	=	=	SYM
admet-193	161	19	s0	s0	PROPN
admet-193	161	20	.	.	PUNCT
admet-193	162	1	the	the	DET
admet-193	162	2	majority	majority	NOUN
admet-193	162	3	of	of	ADP
admet-193	162	4	the	the	DET
admet-193	162	5	aqueous	aqueous	ADJ
admet-193	162	6	solubility	solubility	NOUN
admet-193	162	7	values	value	NOUN
admet-193	162	8	,	,	PUNCT
admet-193	162	9	sw	sw	PROPN
admet-193	162	10	,	,	PUNCT
admet-193	162	11	were	be	AUX
admet-193	162	12	measured	measure	VERB
admet-193	162	13	by	by	ADP
admet-193	162	14	adding	add	VERB
admet-193	162	15	excess	excess	ADJ
admet-193	162	16	solid	solid	ADJ
admet-193	162	17	(	(	PUNCT
admet-193	162	18	ideally	ideally	ADV
admet-193	162	19	,	,	PUNCT
admet-193	162	20	the	the	DET
admet-193	162	21	free	free	ADJ
admet-193	162	22	-	-	PUNCT
admet-193	162	23	acid	acid	ADJ
admet-193	162	24	or	or	CCONJ
admet-193	162	25	free	free	ADJ
admet-193	162	26	-	-	PUNCT
admet-193	162	27	base	base	NOUN
admet-193	162	28	,	,	PUNCT
admet-193	162	29	not	not	PART
admet-193	162	30	the	the	DET
admet-193	162	31	salt	salt	NOUN
admet-193	162	32	)	)	PUNCT
admet-193	162	33	to	to	ADP
admet-193	162	34	distilled	distil	VERB
admet-193	162	35	water	water	NOUN
admet-193	162	36	.	.	PUNCT
admet-193	163	1	frequently	frequently	ADV
admet-193	163	2	,	,	PUNCT
admet-193	163	3	ph	ph	NOUN
admet-193	163	4	of	of	ADP
admet-193	163	5	the	the	DET
admet-193	163	6	saturated	saturate	VERB
admet-193	163	7	solution	solution	NOUN
admet-193	163	8	,	,	PUNCT
admet-193	163	9	phsat	phsat	NOUN
admet-193	163	10	,	,	PUNCT
admet-193	163	11	was	be	AUX
admet-193	163	12	not	not	PART
admet-193	163	13	reported	report	VERB
admet-193	163	14	(	(	PUNCT
admet-193	163	15	and	and	CCONJ
admet-193	163	16	probably	probably	ADV
admet-193	163	17	not	not	PART
admet-193	163	18	measured	measure	VERB
admet-193	163	19	)	)	PUNCT
admet-193	163	20	.	.	PUNCT
admet-193	164	1	when	when	SCONJ
admet-193	164	2	a	a	DET
admet-193	164	3	moderately	moderately	ADV
admet-193	164	4	soluble	soluble	ADJ
admet-193	164	5	weak	weak	ADJ
admet-193	164	6	acid	acid	NOUN
admet-193	164	7	or	or	CCONJ
admet-193	164	8	base	base	NOUN
admet-193	164	9	is	be	AUX
admet-193	164	10	added	add	VERB
admet-193	164	11	to	to	ADP
admet-193	164	12	distilled	distilled	ADJ
admet-193	164	13	water	water	NOUN
admet-193	164	14	,	,	PUNCT
admet-193	164	15	the	the	DET
admet-193	164	16	aqueous	aqueous	ADJ
admet-193	164	17	ph	ph	NOUN
admet-193	164	18	is	be	AUX
admet-193	164	19	altered	alter	VERB
admet-193	164	20	by	by	ADP
admet-193	164	21	the	the	DET
admet-193	164	22	ionizing	ionize	VERB
admet-193	164	23	molecule	molecule	NOUN
admet-193	164	24	,	,	PUNCT
admet-193	164	25	in	in	ADP
admet-193	164	26	the	the	DET
admet-193	164	27	direction	direction	NOUN
admet-193	164	28	where	where	SCONJ
admet-193	164	29	the	the	DET
admet-193	164	30	molecule	molecule	NOUN
admet-193	164	31	remains	remain	VERB
admet-193	164	32	largely	largely	ADV
admet-193	164	33	in	in	ADP
admet-193	164	34	the	the	DET
admet-193	164	35	uncharged	uncharged	ADJ
admet-193	164	36	form	form	NOUN
admet-193	164	37	:	:	PUNCT
admet-193	164	38	sw	sw	PROPN
admet-193	164	39	≈	≈	PROPN
admet-193	164	40	s0	s0	PROPN
admet-193	164	41	,	,	PUNCT
admet-193	164	42	provided	provide	VERB
admet-193	164	43	the	the	DET
admet-193	164	44	compound	compound	NOUN
admet-193	164	45	is	be	AUX
admet-193	164	46	added	add	VERB
admet-193	164	47	as	as	ADP
admet-193	164	48	a	a	DET
admet-193	164	49	pure	pure	ADJ
admet-193	164	50	free	free	ADJ
admet-193	164	51	acid	acid	NOUN
admet-193	164	52	or	or	CCONJ
admet-193	164	53	free	free	ADJ
admet-193	164	54	base	base	NOUN
admet-193	164	55	.	.	PUNCT
admet-193	165	1	for	for	ADP
admet-193	165	2	compounds	compound	NOUN
admet-193	165	3	added	add	VERB
admet-193	165	4	as	as	ADP
admet-193	165	5	salts	salt	NOUN
admet-193	165	6	,	,	PUNCT
admet-193	165	7	it	it	PRON
admet-193	165	8	is	be	AUX
admet-193	165	9	frequently	frequently	ADV
admet-193	165	10	not	not	PART
admet-193	165	11	possible	possible	ADJ
admet-193	165	12	to	to	PART
admet-193	165	13	deduce	deduce	VERB
admet-193	165	14	s0	s0	NOUN
admet-193	165	15	and	and	CCONJ
admet-193	165	16	phsat	phsat	VERB
admet-193	165	17	from	from	ADP
admet-193	165	18	just	just	ADV
admet-193	165	19	sw	sw	PROPN
admet-193	165	20	and	and	CCONJ
admet-193	165	21	pka	pka	PROPN
admet-193	165	22	,	,	PUNCT
admet-193	165	23	since	since	SCONJ
admet-193	165	24	the	the	DET
admet-193	165	25	total	total	ADJ
admet-193	165	26	added	add	VERB
admet-193	165	27	amount	amount	NOUN
admet-193	165	28	of	of	ADP
admet-193	165	29	compound	compound	NOUN
admet-193	165	30	can	can	AUX
admet-193	165	31	affect	affect	VERB
admet-193	165	32	the	the	DET
admet-193	165	33	disposition	disposition	NOUN
admet-193	165	34	of	of	ADP
admet-193	165	35	the	the	DET
admet-193	165	36	saturated	saturate	VERB
admet-193	165	37	solution	solution	NOUN
admet-193	165	38	.	.	PUNCT
admet-193	166	1	for	for	ADP
admet-193	166	2	example	example	NOUN
admet-193	166	3	,	,	PUNCT
admet-193	166	4	if	if	SCONJ
admet-193	166	5	not	not	PART
admet-193	166	6	enough	enough	ADJ
admet-193	166	7	salt	salt	NOUN
admet-193	166	8	form	form	NOUN
admet-193	166	9	of	of	ADP
admet-193	166	10	the	the	DET
admet-193	166	11	admet	admet	PROPN
admet-193	166	12	&	&	CCONJ
admet-193	166	13	dmpk	dmpk	PROPN
admet-193	166	14	3(2	3(2	NUM
admet-193	166	15	)	)	PUNCT
admet-193	166	16	(	(	PUNCT
admet-193	166	17	2015	2015	NUM
admet-193	166	18	)	)	PUNCT
admet-193	166	19	84	84	NUM
admet-193	166	20	-	-	SYM
admet-193	166	21	109	109	NUM
admet-193	166	22	equilibrium	equilibrium	NOUN
admet-193	166	23	solubility	solubility	NOUN
admet-193	166	24	measurements	measurement	NOUN
admet-193	166	25	improvements	improvement	NOUN
admet-193	166	26	doi	doi	NOUN
admet-193	166	27	:	:	PUNCT
admet-193	166	28	10.5599	10.5599	NUM
admet-193	166	29	/	/	SYM
admet-193	166	30	admet.3.2.193	admet.3.2.193	PROPN
admet-193	166	31	91	91	NUM
admet-193	166	32	drug	drug	NOUN
admet-193	166	33	is	be	AUX
admet-193	166	34	added	add	VERB
admet-193	166	35	,	,	PUNCT
admet-193	166	36	the	the	DET
admet-193	166	37	solid	solid	ADJ
admet-193	166	38	disproportionates	disproportionate	NOUN
admet-193	166	39	to	to	ADP
admet-193	166	40	the	the	DET
admet-193	166	41	free	free	ADJ
admet-193	166	42	acid	acid	NOUN
admet-193	166	43	/	/	SYM
admet-193	166	44	base	base	NOUN
admet-193	166	45	in	in	ADP
admet-193	166	46	the	the	DET
admet-193	166	47	saturated	saturate	VERB
admet-193	166	48	solution	solution	NOUN
admet-193	166	49	,	,	PUNCT
admet-193	166	50	with	with	ADP
admet-193	166	51	phsat	phsat	NOUN
admet-193	166	52	depending	depend	VERB
admet-193	166	53	on	on	ADP
admet-193	166	54	the	the	DET
admet-193	166	55	weight	weight	NOUN
admet-193	166	56	of	of	ADP
admet-193	166	57	salt	salt	NOUN
admet-193	166	58	added	add	VERB
admet-193	166	59	.	.	PUNCT
admet-193	167	1	if	if	SCONJ
admet-193	167	2	the	the	DET
admet-193	167	3	ionizable	ionizable	ADJ
admet-193	167	4	compound	compound	NOUN
admet-193	167	5	is	be	AUX
admet-193	167	6	practically	practically	ADV
admet-193	167	7	insoluble	insoluble	ADJ
admet-193	167	8	,	,	PUNCT
admet-193	167	9	then	then	ADV
admet-193	167	10	the	the	DET
admet-193	167	11	value	value	NOUN
admet-193	167	12	of	of	ADP
admet-193	167	13	sw	sw	PROPN
admet-193	167	14	can	can	AUX
admet-193	167	15	be	be	AUX
admet-193	167	16	quite	quite	ADV
admet-193	167	17	different	different	ADJ
admet-193	167	18	from	from	ADP
admet-193	167	19	s0	s0	PROPN
admet-193	167	20	,	,	PUNCT
admet-193	167	21	since	since	SCONJ
admet-193	167	22	not	not	PART
admet-193	167	23	enough	enough	ADJ
admet-193	167	24	of	of	ADP
admet-193	167	25	the	the	DET
admet-193	167	26	compound	compound	NOUN
admet-193	167	27	dissolves	dissolve	VERB
admet-193	167	28	to	to	PART
admet-193	167	29	alter	alter	VERB
admet-193	167	30	the	the	DET
admet-193	167	31	ph	ph	NOUN
admet-193	167	32	in	in	ADP
admet-193	167	33	the	the	DET
admet-193	167	34	direction	direction	NOUN
admet-193	167	35	of	of	ADP
admet-193	167	36	maintaining	maintain	VERB
admet-193	167	37	a	a	DET
admet-193	167	38	nearly	nearly	ADV
admet-193	167	39	uncharged	uncharged	ADJ
admet-193	167	40	molecule	molecule	NOUN
admet-193	167	41	.	.	PUNCT
admet-193	168	1	in	in	ADP
admet-193	168	2	such	such	ADJ
admet-193	168	3	cases	case	NOUN
admet-193	168	4	,	,	PUNCT
admet-193	168	5	it	it	PRON
admet-193	168	6	is	be	AUX
admet-193	168	7	possible	possible	ADJ
admet-193	168	8	to	to	PART
admet-193	168	9	calculate	calculate	VERB
admet-193	168	10	the	the	DET
admet-193	168	11	phsat	phsat	NOUN
admet-193	168	12	,	,	PUNCT
admet-193	168	13	as	as	ADV
admet-193	168	14	well	well	ADV
admet-193	168	15	as	as	ADP
admet-193	168	16	s0	s0	NOUN
admet-193	168	17	,	,	PUNCT
admet-193	168	18	provided	provide	VERB
admet-193	168	19	the	the	DET
admet-193	168	20	pka	pka	PROPN
admet-193	168	21	is	be	AUX
admet-193	168	22	known	know	VERB
admet-193	168	23	and	and	CCONJ
admet-193	168	24	that	that	SCONJ
admet-193	168	25	the	the	DET
admet-193	168	26	henderson	henderson	PROPN
admet-193	168	27	-	-	PUNCT
admet-193	168	28	hasselbalch	hasselbalch	PROPN
admet-193	168	29	equation	equation	NOUN
admet-193	168	30	accurately	accurately	ADV
admet-193	168	31	describes	describe	VERB
admet-193	168	32	the	the	DET
admet-193	168	33	solubility	solubility	NOUN
admet-193	168	34	-	-	PUNCT
admet-193	168	35	ph	ph	NOUN
admet-193	168	36	relationship	relationship	NOUN
admet-193	168	37	for	for	ADP
admet-193	168	38	a	a	DET
admet-193	168	39	one	one	NUM
admet-193	168	40	-	-	PUNCT
admet-193	168	41	pka	pka	NOUN
admet-193	168	42	molecule	molecule	NOUN
admet-193	168	43	(	(	PUNCT
admet-193	168	44	‘	'	PUNCT
admet-193	168	45	±	±	NUM
admet-193	168	46	’	'	PUNCT
admet-193	168	47	in	in	ADP
admet-193	168	48	eq	eq	NOUN
admet-193	168	49	.	.	PROPN
admet-193	168	50	1	1	NUM
admet-193	168	51	:	:	PUNCT
admet-193	168	52	acid	acid	VERB
admet-193	168	53	when	when	SCONJ
admet-193	168	54	‘	'	PUNCT
admet-193	168	55	+	+	NOUN
admet-193	168	56	’	'	PUNCT
admet-193	168	57	and	and	CCONJ
admet-193	168	58	base	base	NOUN
admet-193	168	59	when	when	SCONJ
admet-193	168	60	‘	'	PUNCT
admet-193	168	61	-	-	PUNCT
admet-193	168	62	‘	'	PUNCT
admet-193	168	63	):	):	PUNCT
admet-193	168	64	log	log	PROPN
admet-193	168	65	s	s	PART
admet-193	168	66	=	=	NOUN
admet-193	168	67	log	log	NOUN
admet-193	168	68	s0	s0	NOUN
admet-193	168	69	+	+	CCONJ
admet-193	168	70	log	log	PROPN
admet-193	168	71	{	{	PUNCT
admet-193	168	72	10	10	NUM
admet-193	168	73	±(ph	±(ph	NOUN
admet-193	168	74	–	–	PUNCT
admet-193	168	75	pka	pka	NOUN
admet-193	168	76	)	)	PUNCT
admet-193	168	77	+	+	CCONJ
admet-193	168	78	1	1	X
admet-193	168	79	}	}	PUNCT
admet-193	168	80	(	(	PUNCT
admet-193	168	81	1	1	NUM
admet-193	168	82	)	)	PUNCT
admet-193	168	83	more	more	ADV
admet-193	168	84	complex	complex	ADJ
admet-193	168	85	henderson	henderson	PROPN
admet-193	168	86	-	-	PUNCT
admet-193	168	87	hasselbalch	hasselbalch	PROPN
admet-193	168	88	equations	equation	NOUN
admet-193	168	89	for	for	ADP
admet-193	168	90	ampholytes	ampholyte	NOUN
admet-193	168	91	and	and	CCONJ
admet-193	168	92	multiprotic	multiprotic	ADJ
admet-193	168	93	acids	acid	NOUN
admet-193	168	94	and	and	CCONJ
admet-193	168	95	bases	basis	NOUN
admet-193	168	96	have	have	AUX
admet-193	168	97	been	be	AUX
admet-193	168	98	tabulated	tabulate	VERB
admet-193	168	99	elsewhere	elsewhere	ADV
admet-193	168	100	[	[	X
admet-193	168	101	52,57	52,57	NOUN
admet-193	168	102	]	]	PUNCT
admet-193	168	103	.	.	PUNCT
admet-193	169	1	a	a	DET
admet-193	169	2	feature	feature	NOUN
admet-193	169	3	of	of	ADP
admet-193	169	4	pdisol	pdisol	ADJ
admet-193	169	5	-	-	PUNCT
admet-193	169	6	x	x	PRON
admet-193	169	7	allows	allow	VERB
admet-193	169	8	the	the	DET
admet-193	169	9	calculation	calculation	NOUN
admet-193	169	10	of	of	ADP
admet-193	169	11	phsat	phsat	NOUN
admet-193	169	12	:	:	PUNCT
admet-193	169	13	when	when	SCONJ
admet-193	169	14	the	the	DET
admet-193	169	15	ph	ph	NOUN
admet-193	169	16	is	be	AUX
admet-193	169	17	not	not	PART
admet-193	169	18	reported	report	VERB
admet-193	169	19	with	with	ADP
admet-193	169	20	the	the	DET
admet-193	169	21	sw	sw	PROPN
admet-193	169	22	value	value	NOUN
admet-193	169	23	,	,	PUNCT
admet-193	169	24	a	a	DET
admet-193	169	25	phsat	phsat	NOUN
admet-193	169	26	of	of	ADP
admet-193	169	27	7.0	7.0	NUM
admet-193	169	28	is	be	AUX
admet-193	169	29	initially	initially	ADV
admet-193	169	30	assumed	assume	VERB
admet-193	169	31	,	,	PUNCT
admet-193	169	32	and	and	CCONJ
admet-193	169	33	the	the	DET
admet-193	169	34	regular	regular	ADJ
admet-193	169	35	mass	mass	NOUN
admet-193	169	36	balance	balance	NOUN
admet-193	169	37	regression	regression	NOUN
admet-193	169	38	analysis	analysis	NOUN
admet-193	169	39	is	be	AUX
admet-193	169	40	performed	perform	VERB
admet-193	169	41	[	[	PUNCT
admet-193	169	42	32	32	NUM
admet-193	169	43	]	]	PUNCT
admet-193	169	44	.	.	PUNCT
admet-193	170	1	(	(	PUNCT
admet-193	170	2	fixed	fix	VERB
admet-193	170	3	values	value	NOUN
admet-193	170	4	of	of	ADP
admet-193	170	5	carbon	carbon	NOUN
admet-193	170	6	dioxide	dioxide	NOUN
admet-193	170	7	may	may	AUX
admet-193	170	8	be	be	AUX
admet-193	170	9	included	include	VERB
admet-193	170	10	.	.	PUNCT
admet-193	170	11	)	)	PUNCT
admet-193	171	1	the	the	DET
admet-193	171	2	ph	ph	ADJ
admet-193	171	3	titrant	titrant	NOUN
admet-193	171	4	volume	volume	NOUN
admet-193	171	5	is	be	AUX
admet-193	171	6	calculated	calculate	VERB
admet-193	171	7	.	.	PUNCT
admet-193	172	1	if	if	SCONJ
admet-193	172	2	the	the	DET
admet-193	172	3	volume	volume	NOUN
admet-193	172	4	is	be	AUX
admet-193	172	5	non	non	ADJ
admet-193	172	6	-	-	ADJ
admet-193	172	7	zero	zero	NUM
admet-193	172	8	,	,	PUNCT
admet-193	172	9	the	the	DET
admet-193	172	10	value	value	NOUN
admet-193	172	11	of	of	ADP
admet-193	172	12	phsat	phsat	NOUN
admet-193	172	13	is	be	AUX
admet-193	172	14	adjusted	adjust	VERB
admet-193	172	15	iteratively	iteratively	ADV
admet-193	172	16	by	by	ADP
admet-193	172	17	the	the	DET
admet-193	172	18	regression	regression	NOUN
admet-193	172	19	procedure	procedure	NOUN
admet-193	172	20	until	until	SCONJ
admet-193	172	21	the	the	DET
admet-193	172	22	calculated	calculate	VERB
admet-193	172	23	volume	volume	NOUN
admet-193	172	24	is	be	AUX
admet-193	172	25	driven	drive	VERB
admet-193	172	26	to	to	ADP
admet-193	172	27	zero	zero	NUM
admet-193	172	28	.	.	PUNCT
admet-193	173	1	at	at	ADP
admet-193	173	2	the	the	DET
admet-193	173	3	same	same	ADJ
admet-193	173	4	time	time	NOUN
admet-193	173	5	,	,	PUNCT
admet-193	173	6	s0	s0	PROPN
admet-193	173	7	is	be	AUX
admet-193	173	8	refined	refine	VERB
admet-193	173	9	.	.	PUNCT
admet-193	174	1	variance	variance	NOUN
admet-193	174	2	increase	increase	NOUN
admet-193	174	3	due	due	ADJ
admet-193	174	4	to	to	ADP
admet-193	174	5	pooling	pool	VERB
admet-193	174	6	of	of	ADP
admet-193	174	7	training	training	NOUN
admet-193	174	8	set	set	VERB
admet-193	174	9	solubility	solubility	NOUN
admet-193	174	10	data	datum	NOUN
admet-193	174	11	determined	determine	VERB
admet-193	174	12	at	at	ADP
admet-193	174	13	different	different	ADJ
admet-193	174	14	temperatures	temperature	NOUN
admet-193	174	15	it	it	PRON
admet-193	174	16	appears	appear	VERB
admet-193	174	17	that	that	SCONJ
admet-193	174	18	many	many	ADJ
admet-193	174	19	of	of	ADP
admet-193	174	20	the	the	DET
admet-193	174	21	published	publish	VERB
admet-193	174	22	prediction	prediction	NOUN
admet-193	174	23	studies	study	NOUN
admet-193	174	24	have	have	AUX
admet-193	174	25	drawn	draw	VERB
admet-193	174	26	data	datum	NOUN
admet-193	174	27	from	from	ADP
admet-193	174	28	two	two	NUM
admet-193	174	29	large	large	ADJ
admet-193	174	30	secondary	secondary	ADJ
admet-193	174	31	sources	source	NOUN
admet-193	174	32	,	,	PUNCT
admet-193	174	33	as	as	SCONJ
admet-193	174	34	noted	note	VERB
admet-193	174	35	above	above	ADV
admet-193	174	36	.	.	PUNCT
admet-193	175	1	these	these	DET
admet-193	175	2	two	two	NUM
admet-193	175	3	compilations	compilation	NOUN
admet-193	175	4	have	have	VERB
admet-193	175	5	data	datum	NOUN
admet-193	175	6	collected	collect	VERB
admet-193	175	7	mostly	mostly	ADV
admet-193	175	8	in	in	ADP
admet-193	175	9	the	the	DET
admet-193	175	10	range	range	NOUN
admet-193	175	11	20	20	NUM
admet-193	175	12	–	–	SYM
admet-193	175	13	40	40	NUM
admet-193	175	14	°	°	NOUN
admet-193	175	15	c	c	NOUN
admet-193	175	16	,	,	PUNCT
admet-193	175	17	roughly	roughly	ADV
admet-193	175	18	in	in	ADP
admet-193	175	19	a	a	DET
admet-193	175	20	bimodal	bimodal	NOUN
admet-193	175	21	distribution	distribution	NOUN
admet-193	175	22	(	(	PUNCT
admet-193	175	23	cf	cf	NOUN
admet-193	175	24	.	.	NOUN
admet-193	175	25	,	,	PUNCT
admet-193	175	26	fig	fig	NOUN
admet-193	175	27	.	.	PUNCT
admet-193	176	1	1c	1c	NOUN
admet-193	176	2	)	)	PUNCT
admet-193	176	3	.	.	PUNCT
admet-193	177	1	some	some	DET
admet-193	177	2	prediction	prediction	NOUN
admet-193	177	3	papers	paper	NOUN
admet-193	177	4	state	state	VERB
admet-193	177	5	that	that	SCONJ
admet-193	177	6	only	only	ADV
admet-193	177	7	25	25	NUM
admet-193	177	8	°	°	NOUN
admet-193	177	9	c	c	NOUN
admet-193	177	10	data	datum	NOUN
admet-193	177	11	were	be	AUX
admet-193	177	12	used	use	VERB
admet-193	177	13	.	.	PUNCT
admet-193	178	1	many	many	ADJ
admet-193	178	2	prediction	prediction	NOUN
admet-193	178	3	papers	paper	NOUN
admet-193	178	4	are	be	AUX
admet-193	178	5	less	less	ADV
admet-193	178	6	clear	clear	ADJ
admet-193	178	7	,	,	PUNCT
admet-193	178	8	and	and	CCONJ
admet-193	178	9	it	it	PRON
admet-193	178	10	might	might	AUX
admet-193	178	11	be	be	AUX
admet-193	178	12	that	that	SCONJ
admet-193	178	13	some	some	DET
admet-193	178	14	pooling	pooling	NOUN
admet-193	178	15	from	from	ADP
admet-193	178	16	different	different	ADJ
admet-193	178	17	temperatures	temperature	NOUN
admet-193	178	18	takes	take	VERB
admet-193	178	19	place	place	NOUN
admet-193	178	20	,	,	PUNCT
admet-193	178	21	which	which	PRON
admet-193	178	22	would	would	AUX
admet-193	178	23	contribute	contribute	VERB
admet-193	178	24	to	to	ADP
admet-193	178	25	increased	increase	VERB
admet-193	178	26	variance	variance	NOUN
admet-193	178	27	in	in	ADP
admet-193	178	28	the	the	DET
admet-193	178	29	experimental	experimental	ADJ
admet-193	178	30	training	training	NOUN
admet-193	178	31	set	set	VERB
admet-193	178	32	data	datum	NOUN
admet-193	178	33	.	.	PUNCT
admet-193	179	1	if	if	SCONJ
admet-193	179	2	the	the	DET
admet-193	179	3	temperature	temperature	NOUN
admet-193	179	4	dependence	dependence	NOUN
admet-193	179	5	of	of	ADP
admet-193	179	6	solubility	solubility	NOUN
admet-193	179	7	could	could	AUX
admet-193	179	8	be	be	AUX
admet-193	179	9	predicted	predict	VERB
admet-193	179	10	,	,	PUNCT
admet-193	179	11	then	then	ADV
admet-193	179	12	the	the	DET
admet-193	179	13	number	number	NOUN
admet-193	179	14	of	of	ADP
admet-193	179	15	available	available	ADJ
admet-193	179	16	training	training	NOUN
admet-193	179	17	set	set	VERB
admet-193	179	18	values	value	NOUN
admet-193	179	19	in	in	ADP
admet-193	179	20	the	the	DET
admet-193	179	21	former	former	ADJ
admet-193	179	22	case	case	NOUN
admet-193	179	23	would	would	AUX
admet-193	179	24	increase	increase	VERB
admet-193	179	25	,	,	PUNCT
admet-193	179	26	and	and	CCONJ
admet-193	179	27	in	in	ADP
admet-193	179	28	the	the	DET
admet-193	179	29	latter	latter	ADJ
admet-193	179	30	case	case	NOUN
admet-193	179	31	the	the	DET
admet-193	179	32	variance	variance	NOUN
admet-193	179	33	in	in	ADP
admet-193	179	34	the	the	DET
admet-193	179	35	measured	measured	ADJ
admet-193	179	36	data	datum	NOUN
admet-193	179	37	would	would	AUX
admet-193	179	38	decrease	decrease	VERB
admet-193	179	39	.	.	PUNCT
admet-193	180	1	that	that	PRON
admet-193	180	2	is	is	ADV
admet-193	180	3	,	,	PUNCT
admet-193	180	4	solubility	solubility	NOUN
admet-193	180	5	values	value	NOUN
admet-193	180	6	could	could	AUX
admet-193	180	7	be	be	AUX
admet-193	180	8	normalized	normalize	VERB
admet-193	180	9	to	to	ADP
admet-193	180	10	a	a	DET
admet-193	180	11	single	single	ADJ
admet-193	180	12	reference	reference	NOUN
admet-193	180	13	temperature	temperature	NOUN
admet-193	180	14	,	,	PUNCT
admet-193	180	15	e.g.	e.g.	ADV
admet-193	180	16	,	,	PUNCT
admet-193	180	17	25	25	NUM
admet-193	180	18	°	°	NOUN
admet-193	180	19	c	c	NOUN
admet-193	180	20	.	.	PUNCT
admet-193	181	1	as	as	ADV
admet-193	181	2	far	far	ADV
admet-193	181	3	as	as	SCONJ
admet-193	181	4	we	we	PRON
admet-193	181	5	are	be	AUX
admet-193	181	6	aware	aware	ADJ
admet-193	181	7	,	,	PUNCT
admet-193	181	8	there	there	PRON
admet-193	181	9	are	be	VERB
admet-193	181	10	no	no	DET
admet-193	181	11	publications	publication	NOUN
admet-193	181	12	where	where	SCONJ
admet-193	181	13	temperature	temperature	NOUN
admet-193	181	14	dependence	dependence	NOUN
admet-193	181	15	of	of	ADP
admet-193	181	16	solubility	solubility	NOUN
admet-193	181	17	is	be	AUX
admet-193	181	18	predicted	predict	VERB
admet-193	181	19	solely	solely	ADV
admet-193	181	20	from	from	ADP
admet-193	181	21	2d	2d	NUM
admet-193	181	22	structures	structure	NOUN
admet-193	181	23	.	.	PUNCT
admet-193	182	1	we	we	PRON
admet-193	182	2	have	have	AUX
admet-193	182	3	collected	collect	VERB
admet-193	182	4	a	a	DET
admet-193	182	5	database	database	NOUN
admet-193	182	6	of	of	ADP
admet-193	182	7	626	626	NUM
admet-193	182	8	values	value	NOUN
admet-193	182	9	of	of	ADP
admet-193	182	10	enthalpies	enthalpy	NOUN
admet-193	182	11	of	of	ADP
admet-193	182	12	solution	solution	NOUN
admet-193	182	13	,	,	PUNCT
admet-193	182	14	with	with	ADP
admet-193	182	15	77	77	NUM
admet-193	182	16	determined	determine	VERB
admet-193	182	17	by	by	ADP
admet-193	182	18	calorimetric	calorimetric	ADJ
admet-193	182	19	methods	method	NOUN
admet-193	182	20	,	,	PUNCT
admet-193	182	21	and	and	CCONJ
admet-193	182	22	the	the	DET
admet-193	182	23	rest	rest	NOUN
admet-193	182	24	by	by	ADP
admet-193	182	25	solubility	solubility	NOUN
admet-193	182	26	methods	method	NOUN
admet-193	182	27	(	(	PUNCT
admet-193	182	28	van’t	van’t	NUM
admet-193	182	29	hoff	hoff	NOUN
admet-193	182	30	slopes	slope	NOUN
admet-193	182	31	from	from	ADP
admet-193	182	32	log	log	PROPN
admet-193	182	33	s	s	PROPN
admet-193	182	34	vs.	vs.	ADP
admet-193	182	35	1	1	NUM
admet-193	182	36	/	/	SYM
admet-193	182	37	t	t	NOUN
admet-193	182	38	plots	plot	NOUN
admet-193	182	39	)	)	PUNCT
admet-193	182	40	.	.	PUNCT
admet-193	183	1	the	the	DET
admet-193	183	2	calorimetric	calorimetric	ADJ
admet-193	183	3	data	datum	NOUN
admet-193	183	4	are	be	AUX
admet-193	183	5	producing	produce	VERB
admet-193	183	6	the	the	DET
admet-193	183	7	most	most	ADV
admet-193	183	8	promising	promising	ADJ
admet-193	183	9	results	result	NOUN
admet-193	183	10	,	,	PUNCT
admet-193	183	11	with	with	ADP
admet-193	183	12	r2	r2	PROPN
admet-193	183	13	>	>	X
admet-193	183	14	0.5	0.5	NUM
admet-193	183	15	using	use	VERB
admet-193	183	16	just	just	ADV
admet-193	183	17	the	the	DET
admet-193	183	18	abraham	abraham	PROPN
admet-193	183	19	solvation	solvation	NOUN
admet-193	183	20	descriptors	descriptor	NOUN
admet-193	183	21	.	.	PUNCT
admet-193	184	1	this	this	DET
admet-193	184	2	procedure	procedure	NOUN
admet-193	184	3	will	will	AUX
admet-193	184	4	be	be	AUX
admet-193	184	5	described	describe	VERB
admet-193	184	6	in	in	ADP
admet-193	184	7	a	a	DET
admet-193	184	8	separate	separate	ADJ
admet-193	184	9	publication	publication	NOUN
admet-193	184	10	.	.	PUNCT
admet-193	185	1	as	as	ADP
admet-193	185	2	a	a	DET
admet-193	185	3	preliminary	preliminary	ADJ
admet-193	185	4	observation	observation	NOUN
admet-193	185	5	,	,	PUNCT
admet-193	185	6	on	on	ADP
admet-193	185	7	the	the	DET
admet-193	185	8	average	average	ADJ
admet-193	185	9	,	,	PUNCT
admet-193	185	10	measured	measure	VERB
admet-193	185	11	log	log	NOUN
admet-193	185	12	s0	s0	NOUN
admet-193	185	13	values	value	NOUN
admet-193	185	14	increase	increase	VERB
admet-193	185	15	by	by	ADP
admet-193	185	16	0.13	0.13	NUM
admet-193	185	17	log	log	NOUN
admet-193	185	18	unit	unit	NOUN
admet-193	185	19	(	(	PUNCT
admet-193	185	20	cf	cf	NOUN
admet-193	185	21	.	.	NOUN
admet-193	185	22	,	,	PUNCT
admet-193	185	23	fig	fig	NOUN
admet-193	185	24	.	.	PUNCT
admet-193	186	1	1c	1c	NOUN
admet-193	186	2	)	)	PUNCT
admet-193	186	3	,	,	PUNCT
admet-193	186	4	as	as	SCONJ
admet-193	186	5	the	the	DET
admet-193	186	6	temperature	temperature	NOUN
admet-193	186	7	is	be	AUX
admet-193	186	8	raised	raise	VERB
admet-193	186	9	from	from	ADP
admet-193	186	10	25	25	NUM
admet-193	186	11	to	to	PART
admet-193	186	12	37	37	NUM
admet-193	186	13	°	°	NOUN
admet-193	186	14	c	c	NOUN
admet-193	186	15	.	.	PUNCT
admet-193	187	1	in	in	ADP
admet-193	187	2	cases	case	NOUN
admet-193	187	3	where	where	SCONJ
admet-193	187	4	the	the	DET
admet-193	187	5	training	training	NOUN
admet-193	187	6	set	set	NOUN
admet-193	187	7	data	datum	NOUN
admet-193	187	8	are	be	AUX
admet-193	187	9	pooled	pool	VERB
admet-193	187	10	from	from	ADP
admet-193	187	11	multiple	multiple	ADJ
admet-193	187	12	temperatures	temperature	NOUN
admet-193	187	13	,	,	PUNCT
admet-193	187	14	the	the	DET
admet-193	187	15	variance	variance	NOUN
admet-193	187	16	can	can	AUX
admet-193	187	17	be	be	AUX
admet-193	187	18	expected	expect	VERB
admet-193	187	19	to	to	PART
admet-193	187	20	increase	increase	VERB
admet-193	187	21	by	by	ADP
admet-193	187	22	about	about	ADV
admet-193	187	23	0.13	0.13	NUM
admet-193	187	24	log	log	NOUN
admet-193	187	25	unit	unit	NOUN
admet-193	187	26	.	.	PUNCT
admet-193	188	1	this	this	PRON
admet-193	188	2	can	can	AUX
admet-193	188	3	be	be	AUX
admet-193	188	4	avoided	avoid	VERB
admet-193	188	5	if	if	SCONJ
admet-193	188	6	the	the	DET
admet-193	188	7	data	data	NOUN
admet-193	188	8	mining	mining	NOUN
admet-193	188	9	process	process	NOUN
admet-193	188	10	were	be	AUX
admet-193	188	11	to	to	PART
admet-193	188	12	convert	convert	VERB
admet-193	188	13	measurements	measurement	NOUN
admet-193	188	14	to	to	ADP
admet-193	188	15	a	a	DET
admet-193	188	16	single	single	ADJ
admet-193	188	17	reference	reference	NOUN
admet-193	188	18	temperature	temperature	NOUN
admet-193	188	19	.	.	PUNCT
admet-193	189	1	limitations	limitation	NOUN
admet-193	189	2	of	of	ADP
admet-193	189	3	intrinsic	intrinsic	ADJ
admet-193	189	4	solubility	solubility	NOUN
admet-193	189	5	,	,	PUNCT
admet-193	189	6	s0	s0	PROPN
admet-193	189	7	,	,	PUNCT
admet-193	189	8	determined	determine	VERB
admet-193	189	9	from	from	ADP
admet-193	189	10	a	a	DET
admet-193	189	11	single	single	ADJ
admet-193	189	12	measurement	measurement	NOUN
admet-193	189	13	of	of	ADP
admet-193	189	14	sw	sw	PROPN
admet-193	189	15	when	when	SCONJ
admet-193	189	16	measured	measure	VERB
admet-193	189	17	compounds	compound	NOUN
admet-193	189	18	contain	contain	VERB
admet-193	189	19	protogenic	protogenic	ADJ
admet-193	189	20	impurities	impurity	NOUN
admet-193	189	21	,	,	PUNCT
admet-193	189	22	the	the	DET
admet-193	189	23	phsat	phsat	NOUN
admet-193	189	24	may	may	AUX
admet-193	189	25	be	be	AUX
admet-193	189	26	affected	affect	VERB
admet-193	189	27	,	,	PUNCT
admet-193	189	28	which	which	PRON
admet-193	189	29	could	could	AUX
admet-193	189	30	lead	lead	VERB
admet-193	189	31	to	to	ADP
admet-193	189	32	a	a	DET
admet-193	189	33	change	change	NOUN
admet-193	189	34	in	in	ADP
admet-193	189	35	the	the	DET
admet-193	189	36	measured	measured	ADJ
admet-193	189	37	sw	sw	PROPN
admet-193	189	38	.	.	PUNCT
admet-193	190	1	for	for	ADP
admet-193	190	2	this	this	DET
admet-193	190	3	reason	reason	NOUN
admet-193	190	4	,	,	PUNCT
admet-193	190	5	it	it	PRON
admet-193	190	6	is	be	AUX
admet-193	190	7	highly	highly	ADV
admet-193	190	8	recommended	recommend	VERB
admet-193	190	9	that	that	SCONJ
admet-193	190	10	phsat	phsat	NOUN
admet-193	190	11	be	be	AUX
admet-193	190	12	measured	measure	VERB
admet-193	190	13	and	and	CCONJ
admet-193	190	14	not	not	PART
admet-193	190	15	just	just	ADV
admet-193	190	16	calculated	calculate	VERB
admet-193	190	17	.	.	PUNCT
admet-193	191	1	otherwise	otherwise	ADV
admet-193	191	2	,	,	PUNCT
admet-193	191	3	the	the	DET
admet-193	191	4	conversion	conversion	NOUN
admet-193	191	5	of	of	ADP
admet-193	191	6	sw	sw	PROPN
admet-193	191	7	to	to	ADP
admet-193	191	8	s0	s0	PROPN
admet-193	191	9	may	may	AUX
admet-193	191	10	be	be	AUX
admet-193	191	11	inaccurate	inaccurate	ADJ
admet-193	191	12	.	.	PUNCT
admet-193	192	1	avdeef	avdeef	PROPN
admet-193	192	2	admet	admet	PROPN
admet-193	192	3	&	&	CCONJ
admet-193	192	4	dmpk	dmpk	PROPN
admet-193	192	5	3(2	3(2	NUM
admet-193	192	6	)	)	PUNCT
admet-193	192	7	(	(	PUNCT
admet-193	192	8	2015	2015	NUM
admet-193	192	9	)	)	PUNCT
admet-193	192	10	84	84	NUM
admet-193	192	11	-	-	SYM
admet-193	192	12	109	109	NUM
admet-193	192	13	92	92	NUM
admet-193	192	14	abraham	abraham	NOUN
admet-193	192	15	and	and	CCONJ
admet-193	192	16	le	le	X
admet-193	193	1	[	[	X
admet-193	193	2	3	3	X
admet-193	193	3	]	]	PUNCT
admet-193	193	4	discussed	discuss	VERB
admet-193	193	5	the	the	DET
admet-193	193	6	relationship	relationship	NOUN
admet-193	193	7	between	between	ADP
admet-193	193	8	the	the	DET
admet-193	193	9	measured	measured	ADJ
admet-193	193	10	sw	sw	PROPN
admet-193	193	11	and	and	CCONJ
admet-193	193	12	the	the	DET
admet-193	193	13	underlying	underlie	VERB
admet-193	193	14	s0	s0	NOUN
admet-193	193	15	for	for	ADP
admet-193	193	16	ionizable	ionizable	ADJ
admet-193	193	17	molecules	molecule	NOUN
admet-193	193	18	,	,	PUNCT
admet-193	193	19	and	and	CCONJ
admet-193	193	20	identified	identify	VERB
admet-193	193	21	under	under	ADP
admet-193	193	22	which	which	PRON
admet-193	193	23	circumstances	circumstance	NOUN
admet-193	193	24	large	large	ADJ
admet-193	193	25	errors	error	NOUN
admet-193	193	26	could	could	AUX
admet-193	193	27	result	result	VERB
admet-193	193	28	for	for	SCONJ
admet-193	193	29	sw	sw	PROPN
admet-193	193	30	used	use	VERB
admet-193	193	31	(	(	PUNCT
admet-193	193	32	in	in	ADP
admet-193	193	33	place	place	NOUN
admet-193	193	34	of	of	ADP
admet-193	193	35	the	the	DET
admet-193	193	36	calculated	calculated	ADJ
admet-193	193	37	s0	s0	NOUN
admet-193	193	38	)	)	PUNCT
admet-193	193	39	as	as	ADP
admet-193	193	40	the	the	DET
admet-193	193	41	training	training	NOUN
admet-193	193	42	set	set	VERB
admet-193	193	43	values	value	NOUN
admet-193	193	44	.	.	PUNCT
admet-193	194	1	the	the	DET
admet-193	194	2	authors	author	NOUN
admet-193	194	3	derived	derive	VERB
admet-193	194	4	useful	useful	ADJ
admet-193	194	5	plots	plot	NOUN
admet-193	194	6	of	of	ADP
admet-193	194	7	s0	s0	PROPN
admet-193	194	8	/	/	SYM
admet-193	194	9	sw	sw	PROPN
admet-193	194	10	vs.	vs.	ADP
admet-193	194	11	log	log	NOUN
admet-193	194	12	sw	sw	PROPN
admet-193	194	13	for	for	ADP
admet-193	194	14	acids	acid	NOUN
admet-193	194	15	and	and	CCONJ
admet-193	194	16	bases	basis	NOUN
admet-193	194	17	over	over	ADP
admet-193	194	18	a	a	DET
admet-193	194	19	range	range	NOUN
admet-193	194	20	of	of	ADP
admet-193	194	21	pka	pka	PROPN
admet-193	194	22	values	value	NOUN
admet-193	194	23	.	.	PUNCT
admet-193	195	1	for	for	ADP
admet-193	195	2	example	example	NOUN
admet-193	195	3	,	,	PUNCT
admet-193	195	4	sw	sw	PROPN
admet-193	195	5	≈	≈	PROPN
admet-193	195	6	s0	s0	PROPN
admet-193	195	7	for	for	ADP
admet-193	195	8	acids	acid	NOUN
admet-193	195	9	with	with	ADP
admet-193	195	10	pka	pka	PROPN
admet-193	195	11	5	5	NUM
admet-193	195	12	and	and	CCONJ
admet-193	195	13	sw	sw	X
admet-193	195	14	>	>	X
admet-193	195	15	0.001	0.001	NUM
admet-193	195	16	m	m	NOUN
admet-193	195	17	,	,	PUNCT
admet-193	195	18	or	or	CCONJ
admet-193	195	19	with	with	ADP
admet-193	195	20	pka	pka	PROPN
admet-193	195	21	3	3	NUM
admet-193	195	22	and	and	CCONJ
admet-193	195	23	sw	sw	PROPN
admet-193	195	24	>	>	SYM
admet-193	195	25	0.1	0.1	NUM
admet-193	195	26	m.	m.	NOUN
admet-193	195	27	with	with	ADP
admet-193	195	28	bases	basis	NOUN
admet-193	195	29	,	,	PUNCT
admet-193	195	30	sw	sw	PROPN
admet-193	195	31	≈	≈	PROPN
admet-193	195	32	s0	s0	PROPN
admet-193	195	33	for	for	ADP
admet-193	195	34	pka	pka	PROPN
admet-193	195	35	10	10	NUM
admet-193	195	36	with	with	ADP
admet-193	195	37	sw	sw	PROPN
admet-193	195	38	>	>	PUNCT
admet-193	195	39	0.01	0.01	NUM
admet-193	195	40	m	m	PROPN
admet-193	195	41	,	,	PUNCT
admet-193	195	42	or	or	CCONJ
admet-193	195	43	pka	pka	X
admet-193	195	44	8	8	NUM
admet-193	195	45	with	with	ADP
admet-193	195	46	sw	sw	PROPN
admet-193	195	47	>	>	SYM
admet-193	195	48	0.0001	0.0001	NUM
admet-193	195	49	m.	m.	NOUN
admet-193	195	50	there	there	PRON
admet-193	195	51	are	be	VERB
admet-193	195	52	further	further	ADJ
admet-193	195	53	considerations	consideration	NOUN
admet-193	195	54	.	.	PUNCT
admet-193	196	1	when	when	SCONJ
admet-193	196	2	the	the	DET
admet-193	196	3	aqueous	aqueous	ADJ
admet-193	196	4	solubility	solubility	NOUN
admet-193	196	5	of	of	ADP
admet-193	196	6	practically	practically	ADV
admet-193	196	7	insoluble	insoluble	ADJ
admet-193	196	8	free	free	ADJ
admet-193	196	9	bases	basis	NOUN
admet-193	196	10	(	(	PUNCT
admet-193	196	11	pka	pka	X
admet-193	196	12	>	>	X
admet-193	196	13	9	9	NUM
admet-193	196	14	)	)	PUNCT
admet-193	196	15	are	be	AUX
admet-193	196	16	measured	measure	VERB
admet-193	196	17	in	in	ADP
admet-193	196	18	distilled	distil	VERB
admet-193	196	19	water	water	NOUN
admet-193	196	20	,	,	PUNCT
admet-193	196	21	the	the	DET
admet-193	196	22	ph	ph	NOUN
admet-193	196	23	is	be	AUX
admet-193	196	24	only	only	ADV
admet-193	196	25	slightly	slightly	ADV
admet-193	196	26	affected	affect	VERB
admet-193	196	27	by	by	ADP
admet-193	196	28	the	the	DET
admet-193	196	29	extent	extent	NOUN
admet-193	196	30	to	to	PART
admet-193	196	31	which	which	PRON
admet-193	196	32	the	the	DET
admet-193	196	33	base	base	NOUN
admet-193	196	34	dissolves	dissolve	VERB
admet-193	196	35	.	.	PUNCT
admet-193	197	1	most	most	ADV
admet-193	197	2	notably	notably	ADV
admet-193	197	3	,	,	PUNCT
admet-193	197	4	the	the	DET
admet-193	197	5	observed	observe	VERB
admet-193	197	6	ph	ph	NOUN
admet-193	197	7	often	often	ADV
admet-193	197	8	is	be	AUX
admet-193	197	9	regulated	regulate	VERB
admet-193	197	10	by	by	ADP
admet-193	197	11	a	a	DET
admet-193	197	12	much	much	ADV
admet-193	197	13	stronger	strong	ADJ
admet-193	197	14	buffer	buffer	NOUN
admet-193	197	15	present	present	ADJ
admet-193	197	16	in	in	ADP
admet-193	197	17	water	water	NOUN
admet-193	197	18	:	:	PUNCT
admet-193	197	19	ambient	ambient	ADJ
admet-193	197	20	dissolved	dissolve	VERB
admet-193	197	21	carbon	carbon	NOUN
admet-193	197	22	dioxide	dioxide	NOUN
admet-193	197	23	.	.	PUNCT
admet-193	198	1	this	this	PRON
admet-193	198	2	is	be	AUX
admet-193	198	3	often	often	ADV
admet-193	198	4	overlooked	overlook	VERB
admet-193	198	5	.	.	PUNCT
admet-193	199	1	the	the	DET
admet-193	199	2	ph	ph	NOUN
admet-193	199	3	of	of	ADP
admet-193	199	4	the	the	DET
admet-193	199	5	drug	drug	NOUN
admet-193	199	6	-	-	PUNCT
admet-193	199	7	saturated	saturate	VERB
admet-193	199	8	solution	solution	NOUN
admet-193	199	9	can	can	AUX
admet-193	199	10	vary	vary	VERB
admet-193	199	11	from	from	ADP
admet-193	199	12	610	610	NUM
admet-193	199	13	,	,	PUNCT
admet-193	199	14	depending	depend	VERB
admet-193	199	15	on	on	ADP
admet-193	199	16	how	how	SCONJ
admet-193	199	17	much	much	ADJ
admet-193	199	18	co2	co2	NOUN
admet-193	199	19	is	be	AUX
admet-193	199	20	dissolved	dissolve	VERB
admet-193	199	21	in	in	ADP
admet-193	199	22	water	water	NOUN
admet-193	199	23	and	and	CCONJ
admet-193	199	24	how	how	SCONJ
admet-193	199	25	insoluble	insoluble	ADJ
admet-193	199	26	the	the	DET
admet-193	199	27	basic	basic	ADJ
admet-193	199	28	compound	compound	NOUN
admet-193	199	29	is	be	AUX
admet-193	199	30	.	.	PUNCT
admet-193	200	1	for	for	ADP
admet-193	200	2	example	example	NOUN
admet-193	200	3	,	,	PUNCT
admet-193	200	4	rytting	rytte	VERB
admet-193	200	5	et	et	NOUN
admet-193	200	6	al	al	PROPN
admet-193	200	7	.	.	PUNCT
admet-193	201	1	[	[	X
admet-193	201	2	24	24	NUM
admet-193	201	3	]	]	PUNCT
admet-193	201	4	reported	report	VERB
admet-193	201	5	log	log	PROPN
admet-193	201	6	sw	sw	PROPN
admet-193	201	7	=	=	PUNCT
admet-193	201	8	-4.87	-4.87	PROPN
admet-193	201	9	(	(	PUNCT
admet-193	201	10	molarity	molarity	NOUN
admet-193	201	11	)	)	PUNCT
admet-193	201	12	for	for	ADP
admet-193	201	13	terfenadine	terfenadine	NOUN
admet-193	201	14	dissolved	dissolve	VERB
admet-193	201	15	in	in	ADP
admet-193	201	16	water	water	NOUN
admet-193	201	17	.	.	PUNCT
admet-193	202	1	if	if	SCONJ
admet-193	202	2	co2	co2	NOUN
admet-193	202	3	content	content	NOUN
admet-193	202	4	in	in	ADP
admet-193	202	5	solution	solution	NOUN
admet-193	202	6	were	be	AUX
admet-193	202	7	ignored	ignore	VERB
admet-193	202	8	,	,	PUNCT
admet-193	202	9	the	the	DET
admet-193	202	10	calculated	calculate	VERB
admet-193	202	11	log	log	NOUN
admet-193	202	12	s0	s0	NOUN
admet-193	202	13	=	=	PUNCT
admet-193	202	14	-5.7	-5.7	PROPN
admet-193	202	15	and	and	CCONJ
admet-193	202	16	phsat	phsat	VERB
admet-193	202	17	=	=	NOUN
admet-193	202	18	9.2	9.2	NUM
admet-193	202	19	.	.	PUNCT
admet-193	203	1	however	however	ADV
admet-193	203	2	,	,	PUNCT
admet-193	203	3	if	if	SCONJ
admet-193	203	4	[	[	X
admet-193	203	5	co2	co2	X
admet-193	203	6	]	]	X
admet-193	203	7	=	=	SYM
admet-193	203	8	20	20	NUM
admet-193	203	9	μm	μm	NOUN
admet-193	203	10	(	(	PUNCT
admet-193	203	11	a	a	DET
admet-193	203	12	common	common	ADJ
admet-193	203	13	ambient	ambient	ADJ
admet-193	203	14	level	level	NOUN
admet-193	203	15	)	)	PUNCT
admet-193	203	16	,	,	PUNCT
admet-193	203	17	the	the	DET
admet-193	203	18	calculated	calculate	VERB
admet-193	203	19	log	log	NOUN
admet-193	203	20	s0	s0	NOUN
admet-193	203	21	=	=	PUNCT
admet-193	203	22	-8.3	-8.3	PUNCT
admet-193	203	23	and	and	CCONJ
admet-193	203	24	phsat	phsat	ADJ
admet-193	203	25	=	=	PUNCT
admet-193	203	26	6.6	6.6	NUM
admet-193	203	27	.	.	PUNCT
admet-193	204	1	the	the	DET
admet-193	204	2	error	error	NOUN
admet-193	204	3	in	in	ADP
admet-193	204	4	determining	determine	VERB
admet-193	204	5	s0	s0	NOUN
admet-193	204	6	of	of	ADP
admet-193	204	7	molecules	molecule	NOUN
admet-193	204	8	like	like	ADP
admet-193	204	9	terfenadine	terfenadine	NOUN
admet-193	204	10	in	in	ADP
admet-193	204	11	distilled	distil	VERB
admet-193	204	12	water	water	NOUN
admet-193	204	13	is	be	AUX
admet-193	204	14	expected	expect	VERB
admet-193	204	15	to	to	PART
admet-193	204	16	be	be	AUX
admet-193	204	17	enormous	enormous	ADJ
admet-193	204	18	(	(	PUNCT
admet-193	204	19	as	as	ADV
admet-193	204	20	much	much	ADJ
admet-193	204	21	as	as	ADP
admet-193	204	22	3	3	NUM
admet-193	204	23	log	log	NOUN
admet-193	204	24	units	unit	NOUN
admet-193	204	25	)	)	PUNCT
admet-193	204	26	,	,	PUNCT
admet-193	204	27	since	since	SCONJ
admet-193	204	28	it	it	PRON
admet-193	204	29	is	be	AUX
admet-193	204	30	very	very	ADV
admet-193	204	31	difficult	difficult	ADJ
admet-193	204	32	to	to	PART
admet-193	204	33	eliminate	eliminate	VERB
admet-193	204	34	co2	co2	NOUN
admet-193	204	35	entirely	entirely	ADV
admet-193	204	36	simply	simply	ADV
admet-193	204	37	by	by	ADP
admet-193	204	38	bubbling	bubble	VERB
admet-193	204	39	an	an	DET
admet-193	204	40	inert	inert	ADJ
admet-193	204	41	gas	gas	NOUN
admet-193	204	42	through	through	ADP
admet-193	204	43	solution	solution	NOUN
admet-193	204	44	.	.	PUNCT
admet-193	205	1	in	in	ADP
admet-193	205	2	fact	fact	NOUN
admet-193	205	3	,	,	PUNCT
admet-193	205	4	any	any	DET
admet-193	205	5	protogenic	protogenic	ADJ
admet-193	205	6	drug	drug	NOUN
admet-193	205	7	impurity	impurity	NOUN
admet-193	205	8	in	in	ADP
admet-193	205	9	solution	solution	NOUN
admet-193	205	10	under	under	ADP
admet-193	205	11	the	the	DET
admet-193	205	12	circumstances	circumstance	NOUN
admet-193	205	13	would	would	AUX
admet-193	205	14	lead	lead	VERB
admet-193	205	15	to	to	ADP
admet-193	205	16	large	large	ADJ
admet-193	205	17	uncertainties	uncertainty	NOUN
admet-193	205	18	in	in	ADP
admet-193	205	19	the	the	DET
admet-193	205	20	intrinsic	intrinsic	ADJ
admet-193	205	21	solubility	solubility	NOUN
admet-193	205	22	of	of	ADP
admet-193	205	23	the	the	DET
admet-193	205	24	drug	drug	NOUN
admet-193	205	25	substance	substance	NOUN
admet-193	205	26	of	of	ADP
admet-193	205	27	interest	interest	NOUN
admet-193	205	28	.	.	PUNCT
admet-193	206	1	the	the	DET
admet-193	206	2	simple	simple	ADJ
admet-193	206	3	remedy	remedy	NOUN
admet-193	206	4	might	might	AUX
admet-193	206	5	be	be	AUX
admet-193	206	6	to	to	PART
admet-193	206	7	measure	measure	VERB
admet-193	206	8	the	the	DET
admet-193	206	9	ph	ph	NOUN
admet-193	206	10	of	of	ADP
admet-193	206	11	the	the	DET
admet-193	206	12	saturated	saturate	VERB
admet-193	206	13	solution	solution	NOUN
admet-193	206	14	.	.	PUNCT
admet-193	207	1	however	however	ADV
admet-193	207	2	,	,	PUNCT
admet-193	207	3	measuring	measure	VERB
admet-193	207	4	the	the	DET
admet-193	207	5	ph	ph	NOUN
admet-193	207	6	accurately	accurately	ADV
admet-193	207	7	when	when	SCONJ
admet-193	207	8	the	the	DET
admet-193	207	9	solution	solution	NOUN
admet-193	207	10	is	be	AUX
admet-193	207	11	essentially	essentially	ADV
admet-193	207	12	unbuffered	unbuffered	ADJ
admet-193	207	13	is	be	AUX
admet-193	207	14	problematic	problematic	ADJ
admet-193	207	15	,	,	PUNCT
admet-193	207	16	due	due	ADP
admet-193	207	17	to	to	ADP
admet-193	207	18	the	the	DET
admet-193	207	19	effects	effect	NOUN
admet-193	207	20	of	of	ADP
admet-193	207	21	uncontrolled	uncontrolled	ADJ
admet-193	207	22	electrode	electrode	NOUN
admet-193	207	23	junction	junction	NOUN
admet-193	207	24	potentials	potential	NOUN
admet-193	207	25	and	and	CCONJ
admet-193	207	26	other	other	ADJ
admet-193	207	27	factors	factor	NOUN
admet-193	207	28	[	[	X
admet-193	207	29	52	52	NUM
admet-193	207	30	]	]	PUNCT
admet-193	207	31	.	.	PUNCT
admet-193	208	1	added	add	VERB
admet-193	208	2	buffer	buffer	NOUN
admet-193	208	3	improves	improve	VERB
admet-193	208	4	accuracy	accuracy	NOUN
admet-193	208	5	when	when	SCONJ
admet-193	208	6	measuring	measure	VERB
admet-193	208	7	aqueous	aqueous	ADJ
admet-193	208	8	solubility	solubility	NOUN
admet-193	208	9	(	(	PUNCT
admet-193	208	10	sph	sph	NOUN
admet-193	208	11	)	)	PUNCT
admet-193	208	12	at	at	ADP
admet-193	208	13	a	a	DET
admet-193	208	14	single	single	ADJ
admet-193	208	15	ph	ph	NOUN
admet-193	208	16	the	the	DET
admet-193	208	17	above	above	ADJ
admet-193	208	18	terfenadine	terfenadine	NOUN
admet-193	208	19	water	water	NOUN
admet-193	208	20	solubility	solubility	NOUN
admet-193	208	21	example	example	NOUN
admet-193	208	22	illustrates	illustrate	VERB
admet-193	208	23	that	that	SCONJ
admet-193	208	24	high	high	ADJ
admet-193	208	25	errors	error	NOUN
admet-193	208	26	can	can	AUX
admet-193	208	27	result	result	VERB
admet-193	208	28	when	when	SCONJ
admet-193	208	29	the	the	DET
admet-193	208	30	ph	ph	NOUN
admet-193	208	31	of	of	ADP
admet-193	208	32	the	the	DET
admet-193	208	33	saturated	saturate	VERB
admet-193	208	34	solution	solution	NOUN
admet-193	208	35	is	be	AUX
admet-193	208	36	not	not	PART
admet-193	208	37	known	know	VERB
admet-193	208	38	or	or	CCONJ
admet-193	208	39	whose	whose	DET
admet-193	208	40	measurement	measurement	NOUN
admet-193	208	41	is	be	AUX
admet-193	208	42	problematic	problematic	ADJ
admet-193	208	43	.	.	PUNCT
admet-193	209	1	the	the	DET
admet-193	209	2	remedy	remedy	NOUN
admet-193	209	3	is	be	AUX
admet-193	209	4	to	to	PART
admet-193	209	5	buffer	buffer	VERB
admet-193	209	6	the	the	DET
admet-193	209	7	solution	solution	NOUN
admet-193	209	8	(	(	PUNCT
admet-193	209	9	but	but	CCONJ
admet-193	209	10	not	not	PART
admet-193	209	11	excessively	excessively	ADV
admet-193	209	12	)	)	PUNCT
admet-193	209	13	and	and	CCONJ
admet-193	209	14	actually	actually	ADV
admet-193	209	15	measure	measure	VERB
admet-193	209	16	the	the	DET
admet-193	209	17	ph	ph	NOUN
admet-193	209	18	when	when	SCONJ
admet-193	209	19	the	the	DET
admet-193	209	20	saturated	saturate	VERB
admet-193	209	21	solution	solution	NOUN
admet-193	209	22	reaches	reach	VERB
admet-193	209	23	equilibrium	equilibrium	NOUN
admet-193	209	24	.	.	PUNCT
admet-193	210	1	however	however	ADV
admet-193	210	2	,	,	PUNCT
admet-193	210	3	when	when	SCONJ
admet-193	210	4	only	only	ADV
admet-193	210	5	a	a	DET
admet-193	210	6	single	single	ADJ
admet-193	210	7	aqueous	aqueous	ADJ
admet-193	210	8	solubility	solubility	NOUN
admet-193	210	9	at	at	ADP
admet-193	210	10	a	a	DET
admet-193	210	11	known	know	VERB
admet-193	210	12	ph	ph	NOUN
admet-193	210	13	,	,	PUNCT
admet-193	210	14	sph	sph	PROPN
admet-193	210	15	,	,	PUNCT
admet-193	210	16	is	be	AUX
admet-193	210	17	measured	measure	VERB
admet-193	210	18	,	,	PUNCT
admet-193	210	19	it	it	PRON
admet-193	210	20	is	be	AUX
admet-193	210	21	still	still	ADV
admet-193	210	22	necessary	necessary	ADJ
admet-193	210	23	to	to	PART
admet-193	210	24	assume	assume	VERB
admet-193	210	25	that	that	SCONJ
admet-193	210	26	the	the	DET
admet-193	210	27	henderson	henderson	PROPN
admet-193	210	28	-	-	PUNCT
admet-193	210	29	hasselbalch	hasselbalch	PROPN
admet-193	210	30	equation	equation	NOUN
admet-193	210	31	accurately	accurately	ADV
admet-193	210	32	describes	describe	VERB
admet-193	210	33	the	the	DET
admet-193	210	34	log	log	NOUN
admet-193	210	35	s	s	NOUN
admet-193	210	36	ph	ph	NOUN
admet-193	210	37	profile	profile	NOUN
admet-193	210	38	,	,	PUNCT
admet-193	210	39	in	in	ADP
admet-193	210	40	order	order	NOUN
admet-193	210	41	to	to	PART
admet-193	210	42	calculate	calculate	VERB
admet-193	210	43	the	the	DET
admet-193	210	44	s0	s0	NOUN
admet-193	210	45	,	,	PUNCT
admet-193	210	46	given	give	VERB
admet-193	210	47	an	an	DET
admet-193	210	48	accurate	accurate	ADJ
admet-193	210	49	independently	independently	ADV
admet-193	210	50	-	-	PUNCT
admet-193	210	51	determined	determine	VERB
admet-193	210	52	pka	pka	PROPN
admet-193	210	53	.	.	PROPN
admet-193	210	54	measurement	measurement	NOUN
admet-193	210	55	of	of	ADP
admet-193	210	56	aqueous	aqueous	ADJ
admet-193	210	57	solubility	solubility	NOUN
admet-193	210	58	at	at	ADP
admet-193	210	59	several	several	ADJ
admet-193	210	60	buffered	buffer	VERB
admet-193	210	61	ph	ph	NOUN
admet-193	210	62	,	,	PUNCT
admet-193	210	63	below	below	ADV
admet-193	210	64	and	and	CCONJ
admet-193	210	65	above	above	ADP
admet-193	210	66	the	the	DET
admet-193	210	67	pka	pka	PROPN
admet-193	210	68	,	,	PUNCT
admet-193	210	69	for	for	ADP
admet-193	210	70	best	good	ADJ
admet-193	210	71	accuracy	accuracy	NOUN
admet-193	210	72	by	by	ADP
admet-193	210	73	measuring	measure	VERB
admet-193	210	74	solubility	solubility	NOUN
admet-193	210	75	at	at	ADP
admet-193	210	76	several	several	ADJ
admet-193	210	77	different	different	ADJ
admet-193	210	78	values	value	NOUN
admet-193	210	79	of	of	ADP
admet-193	210	80	ph	ph	NOUN
admet-193	210	81	(	(	PUNCT
admet-193	210	82	cf	cf	NOUN
admet-193	210	83	.	.	PUNCT
admet-193	210	84	,	,	PUNCT
admet-193	210	85	fig	fig	NOUN
admet-193	210	86	.	.	PUNCT
admet-193	211	1	2	2	NUM
admet-193	211	2	)	)	PUNCT
admet-193	211	3	below	below	ADP
admet-193	211	4	and	and	CCONJ
admet-193	211	5	above	above	ADP
admet-193	211	6	the	the	DET
admet-193	211	7	pka	pka	NOUN
admet-193	211	8	of	of	ADP
admet-193	211	9	an	an	DET
admet-193	211	10	ionizable	ionizable	ADJ
admet-193	211	11	molecule	molecule	NOUN
admet-193	211	12	,	,	PUNCT
admet-193	211	13	it	it	PRON
admet-193	211	14	’s	’	VERB
admet-193	211	15	possible	possible	ADJ
admet-193	211	16	to	to	PART
admet-193	211	17	overcome	overcome	VERB
admet-193	211	18	several	several	ADJ
admet-193	211	19	of	of	ADP
admet-193	211	20	the	the	DET
admet-193	211	21	above	above	ADJ
admet-193	211	22	sources	source	NOUN
admet-193	211	23	of	of	ADP
admet-193	211	24	error	error	NOUN
admet-193	211	25	.	.	PUNCT
admet-193	212	1	the	the	DET
admet-193	212	2	log	log	NOUN
admet-193	212	3	s	s	NOUN
admet-193	212	4	data	datum	NOUN
admet-193	212	5	as	as	ADP
admet-193	212	6	a	a	DET
admet-193	212	7	function	function	NOUN
admet-193	212	8	of	of	ADP
admet-193	212	9	ph	ph	NOUN
admet-193	212	10	can	can	AUX
admet-193	212	11	be	be	AUX
admet-193	212	12	analyzed	analyze	VERB
admet-193	212	13	,	,	PUNCT
admet-193	212	14	to	to	PART
admet-193	212	15	determine	determine	VERB
admet-193	212	16	the	the	DET
admet-193	212	17	value	value	NOUN
admet-193	212	18	of	of	ADP
admet-193	212	19	s0	s0	PROPN
admet-193	212	20	.	.	PUNCT
admet-193	213	1	the	the	DET
admet-193	213	2	validity	validity	NOUN
admet-193	213	3	of	of	ADP
admet-193	213	4	the	the	DET
admet-193	213	5	henderson	henderson	PROPN
admet-193	213	6	-	-	PUNCT
admet-193	213	7	hasselbalch	hasselbalch	PROPN
admet-193	213	8	equation	equation	NOUN
admet-193	213	9	can	can	AUX
admet-193	213	10	be	be	AUX
admet-193	213	11	easily	easily	ADV
admet-193	213	12	tested	test	VERB
admet-193	213	13	in	in	ADP
admet-193	213	14	such	such	ADJ
admet-193	213	15	analysis	analysis	NOUN
admet-193	213	16	,	,	PUNCT
admet-193	213	17	using	use	VERB
admet-193	213	18	mass	mass	NOUN
admet-193	213	19	-	-	PUNCT
admet-193	213	20	balance	balance	NOUN
admet-193	213	21	based	base	VERB
admet-193	213	22	solubility	solubility	NOUN
admet-193	213	23	simulation	simulation	NOUN
admet-193	213	24	software	software	NOUN
admet-193	213	25	(	(	PUNCT
admet-193	213	26	e.g.	e.g.	ADV
admet-193	213	27	,	,	PUNCT
admet-193	213	28	pdisol	pdisol	ADJ
admet-193	213	29	-	-	PUNCT
admet-193	213	30	x	x	NOUN
admet-193	213	31	)	)	PUNCT
admet-193	213	32	.	.	PUNCT
admet-193	214	1	a	a	DET
admet-193	214	2	universal	universal	ADJ
admet-193	214	3	buffer	buffer	NOUN
admet-193	214	4	mixture	mixture	NOUN
admet-193	214	5	(	(	PUNCT
admet-193	214	6	e.g.	e.g.	ADV
admet-193	214	7	,	,	PUNCT
admet-193	214	8	whose	whose	DET
admet-193	214	9	ph	ph	NOUN
admet-193	214	10	is	be	AUX
admet-193	214	11	nearly	nearly	ADV
admet-193	214	12	linearly	linearly	ADV
admet-193	214	13	controlled	control	VERB
admet-193	214	14	by	by	ADP
admet-193	214	15	added	add	VERB
admet-193	214	16	aliquots	aliquot	NOUN
admet-193	214	17	of	of	ADP
admet-193	214	18	standardized	standardized	ADJ
admet-193	214	19	naoh	naoh	NOUN
admet-193	214	20	solution	solution	NOUN
admet-193	214	21	)	)	PUNCT
admet-193	214	22	or	or	CCONJ
admet-193	214	23	several	several	ADJ
admet-193	214	24	independent	independent	ADJ
admet-193	214	25	buffers	buffer	NOUN
admet-193	214	26	may	may	AUX
admet-193	214	27	be	be	AUX
admet-193	214	28	used	use	VERB
admet-193	214	29	,	,	PUNCT
admet-193	214	30	but	but	CCONJ
admet-193	214	31	the	the	DET
admet-193	214	32	ph	ph	NOUN
admet-193	214	33	still	still	ADV
admet-193	214	34	needs	need	VERB
admet-193	214	35	to	to	PART
admet-193	214	36	be	be	AUX
admet-193	214	37	measured	measure	VERB
admet-193	214	38	when	when	SCONJ
admet-193	214	39	the	the	DET
admet-193	214	40	saturated	saturate	VERB
admet-193	214	41	solution	solution	NOUN
admet-193	214	42	reaches	reach	VERB
admet-193	214	43	equilibrium	equilibrium	NOUN
admet-193	214	44	.	.	PUNCT
admet-193	215	1	it	it	PRON
admet-193	215	2	can	can	AUX
admet-193	215	3	be	be	AUX
admet-193	215	4	misleading	misleading	ADJ
admet-193	215	5	to	to	PART
admet-193	215	6	assume	assume	VERB
admet-193	215	7	that	that	SCONJ
admet-193	215	8	the	the	DET
admet-193	215	9	buffer	buffer	NOUN
admet-193	215	10	ph	ph	NOUN
admet-193	215	11	will	will	AUX
admet-193	215	12	remain	remain	VERB
admet-193	215	13	unchanged	unchanged	ADJ
admet-193	215	14	in	in	ADP
admet-193	215	15	the	the	DET
admet-193	215	16	course	course	NOUN
admet-193	215	17	of	of	ADP
admet-193	215	18	the	the	DET
admet-193	215	19	drug	drug	NOUN
admet-193	215	20	dissolution	dissolution	NOUN
admet-193	215	21	.	.	PUNCT
admet-193	216	1	nor	nor	CCONJ
admet-193	216	2	is	be	AUX
admet-193	216	3	it	it	PRON
admet-193	216	4	a	a	DET
admet-193	216	5	good	good	ADJ
admet-193	216	6	idea	idea	NOUN
admet-193	216	7	to	to	PART
admet-193	216	8	use	use	VERB
admet-193	216	9	excessively	excessively	ADV
admet-193	216	10	high	high	ADJ
admet-193	216	11	concentrations	concentration	NOUN
admet-193	216	12	of	of	ADP
admet-193	216	13	buffers	buffer	NOUN
admet-193	216	14	,	,	PUNCT
admet-193	216	15	since	since	SCONJ
admet-193	216	16	drug	drug	NOUN
admet-193	216	17	-	-	PUNCT
admet-193	216	18	buffer	buffer	NOUN
admet-193	216	19	complexes	complex	NOUN
admet-193	216	20	and	and	CCONJ
admet-193	216	21	precipitates	precipitate	NOUN
admet-193	216	22	may	may	AUX
admet-193	216	23	form	form	VERB
admet-193	216	24	,	,	PUNCT
admet-193	216	25	affecting	affect	VERB
admet-193	216	26	the	the	DET
admet-193	216	27	measured	measured	ADJ
admet-193	216	28	solubility	solubility	NOUN
admet-193	216	29	(	(	PUNCT
admet-193	216	30	shoghi	shoghi	X
admet-193	216	31	et	et	PROPN
admet-193	216	32	al	al	PROPN
admet-193	216	33	.	.	PUNCT
admet-193	217	1	[	[	X
admet-193	217	2	53	53	NUM
admet-193	217	3	]	]	PUNCT
admet-193	217	4	)	)	PUNCT
admet-193	217	5	.	.	PUNCT
admet-193	218	1	in	in	ADP
admet-193	218	2	simply	simply	ADV
admet-193	218	3	-	-	PUNCT
admet-193	218	4	behaving	behave	VERB
admet-193	218	5	systems	system	NOUN
admet-193	218	6	,	,	PUNCT
admet-193	218	7	even	even	ADV
admet-193	218	8	the	the	DET
admet-193	218	9	pka	pka	NOUN
admet-193	218	10	can	can	AUX
admet-193	218	11	be	be	AUX
admet-193	218	12	determined	determine	VERB
admet-193	218	13	from	from	ADP
admet-193	218	14	the	the	DET
admet-193	218	15	log	log	NOUN
admet-193	218	16	s	s	PART
admet-193	218	17	–	–	PUNCT
admet-193	218	18	ph	ph	ADJ
admet-193	218	19	data	datum	NOUN
admet-193	218	20	(	(	PUNCT
admet-193	218	21	zimmermann	zimmermann	PROPN
admet-193	218	22	[	[	X
admet-193	218	23	54	54	NUM
admet-193	218	24	]	]	PUNCT
admet-193	218	25	;	;	PUNCT
admet-193	218	26	cf	cf	X
admet-193	218	27	.	.	PUNCT
admet-193	218	28	,	,	PUNCT
admet-193	218	29	fig	fig	NOUN
admet-193	218	30	.	.	PUNCT
admet-193	219	1	2	2	NUM
admet-193	219	2	)	)	PUNCT
admet-193	219	3	,	,	PUNCT
admet-193	219	4	but	but	CCONJ
admet-193	219	5	this	this	PRON
admet-193	219	6	is	be	AUX
admet-193	219	7	not	not	PART
admet-193	219	8	generally	generally	ADV
admet-193	219	9	recommended	recommend	VERB
admet-193	219	10	[	[	PUNCT
admet-193	219	11	32	32	NUM
admet-193	219	12	-	-	SYM
admet-193	219	13	34	34	NUM
admet-193	219	14	]	]	PUNCT
admet-193	219	15	.	.	PUNCT
admet-193	220	1	it	it	PRON
admet-193	220	2	is	be	AUX
admet-193	220	3	far	far	ADV
admet-193	220	4	more	more	ADV
admet-193	220	5	reliable	reliable	ADJ
admet-193	220	6	to	to	PART
admet-193	220	7	use	use	VERB
admet-193	220	8	purposedesigned	purposedesigne	VERB
admet-193	220	9	pka	pka	PROPN
admet-193	220	10	measurement	measurement	NOUN
admet-193	220	11	techniques	technique	NOUN
admet-193	220	12	(	(	PUNCT
admet-193	220	13	e.g.	e.g.	ADV
admet-193	220	14	,	,	PUNCT
admet-193	220	15	potentiometric	potentiometric	ADJ
admet-193	220	16	,	,	PUNCT
admet-193	220	17	spectrophotometric	spectrophotometric	ADJ
admet-193	220	18	,	,	PUNCT
admet-193	220	19	or	or	CCONJ
admet-193	220	20	capillary	capillary	ADJ
admet-193	220	21	admet	admet	NOUN
admet-193	220	22	&	&	CCONJ
admet-193	220	23	dmpk	dmpk	PROPN
admet-193	220	24	3(2	3(2	NUM
admet-193	220	25	)	)	PUNCT
admet-193	220	26	(	(	PUNCT
admet-193	220	27	2015	2015	NUM
admet-193	220	28	)	)	PUNCT
admet-193	220	29	84	84	NUM
admet-193	220	30	-	-	SYM
admet-193	220	31	109	109	NUM
admet-193	220	32	equilibrium	equilibrium	NOUN
admet-193	220	33	solubility	solubility	NOUN
admet-193	220	34	measurements	measurement	NOUN
admet-193	220	35	improvements	improvement	NOUN
admet-193	220	36	doi	doi	NOUN
admet-193	220	37	:	:	PUNCT
admet-193	220	38	10.5599	10.5599	NUM
admet-193	220	39	/	/	SYM
admet-193	220	40	admet.3.2.193	admet.3.2.193	PROPN
admet-193	220	41	93	93	NUM
admet-193	220	42	electrophoretic	electrophoretic	NOUN
admet-193	220	43	)	)	PUNCT
admet-193	220	44	,	,	PUNCT
admet-193	220	45	under	under	ADP
admet-193	220	46	conditions	condition	NOUN
admet-193	220	47	where	where	SCONJ
admet-193	220	48	ionic	ionic	ADJ
admet-193	220	49	strength	strength	NOUN
admet-193	220	50	is	be	AUX
admet-193	220	51	well	well	ADV
admet-193	220	52	controlled	control	VERB
admet-193	220	53	and	and	CCONJ
admet-193	220	54	complications	complication	NOUN
admet-193	220	55	due	due	ADP
admet-193	220	56	to	to	ADP
admet-193	220	57	sample	sample	NOUN
admet-193	220	58	complexation	complexation	NOUN
admet-193	220	59	,	,	PUNCT
admet-193	220	60	self	self	NOUN
admet-193	220	61	-	-	PUNCT
admet-193	220	62	aggregation	aggregation	NOUN
admet-193	220	63	,	,	PUNCT
admet-193	220	64	or	or	CCONJ
admet-193	220	65	precipitation	precipitation	NOUN
admet-193	220	66	are	be	AUX
admet-193	220	67	avoided	avoid	VERB
admet-193	220	68	.	.	PUNCT
admet-193	221	1	calibration	calibration	NOUN
admet-193	221	2	of	of	ADP
admet-193	221	3	ph	ph	ADJ
admet-193	221	4	electrode	electrode	NOUN
admet-193	221	5	glass	glass	NOUN
admet-193	221	6	ph	ph	NOUN
admet-193	221	7	electrodes	electrode	NOUN
admet-193	221	8	are	be	AUX
admet-193	221	9	not	not	PART
admet-193	221	10	all	all	ADV
admet-193	221	11	equal	equal	ADJ
admet-193	221	12	.	.	PUNCT
admet-193	222	1	there	there	PRON
admet-193	222	2	is	be	VERB
admet-193	222	3	no	no	DET
admet-193	222	4	single	single	ADJ
admet-193	222	5	standard	standard	ADJ
admet-193	222	6	method	method	NOUN
admet-193	222	7	for	for	ADP
admet-193	222	8	calibrating	calibrate	VERB
admet-193	222	9	electrodes	electrode	NOUN
admet-193	222	10	.	.	PUNCT
admet-193	223	1	in	in	ADP
admet-193	223	2	solubility	solubility	NOUN
admet-193	223	3	publications	publication	NOUN
admet-193	223	4	,	,	PUNCT
admet-193	223	5	the	the	DET
admet-193	223	6	electrode	electrode	NOUN
admet-193	223	7	calibration	calibration	NOUN
admet-193	223	8	is	be	AUX
admet-193	223	9	virtually	virtually	ADV
admet-193	223	10	never	never	ADV
admet-193	223	11	described	describe	VERB
admet-193	223	12	.	.	PUNCT
admet-193	224	1	the	the	DET
admet-193	224	2	make	make	NOUN
admet-193	224	3	of	of	ADP
admet-193	224	4	the	the	DET
admet-193	224	5	electrode	electrode	NOUN
admet-193	224	6	is	be	AUX
admet-193	224	7	hardly	hardly	ADV
admet-193	224	8	ever	ever	ADV
admet-193	224	9	stated	state	VERB
admet-193	224	10	.	.	PUNCT
admet-193	225	1	in	in	ADP
admet-193	225	2	contrast	contrast	NOUN
admet-193	225	3	,	,	PUNCT
admet-193	225	4	researchers	researcher	NOUN
admet-193	225	5	who	who	PRON
admet-193	225	6	determine	determine	VERB
admet-193	225	7	pka	pka	PROPN
admet-193	225	8	values	value	NOUN
admet-193	225	9	using	use	VERB
admet-193	225	10	commercial	commercial	ADJ
admet-193	225	11	instruments	instrument	NOUN
admet-193	225	12	are	be	AUX
admet-193	225	13	well	well	ADV
admet-193	225	14	acquainted	acquaint	VERB
admet-193	225	15	with	with	ADP
admet-193	225	16	the	the	DET
admet-193	225	17	routinely	routinely	ADV
admet-193	225	18	-	-	PUNCT
admet-193	225	19	used	use	VERB
admet-193	225	20	four	four	NUM
admet-193	225	21	-	-	PUNCT
admet-193	225	22	parameter	parameter	NOUN
admet-193	225	23	procedure	procedure	NOUN
admet-193	225	24	(	(	PUNCT
admet-193	225	25	avdeef	avdeef	NOUN
admet-193	225	26	and	and	CCONJ
admet-193	225	27	bucher	bucher	NOUN
admet-193	225	28	[	[	X
admet-193	225	29	55	55	NUM
admet-193	225	30	]	]	NUM
admet-193	225	31	)	)	PUNCT
admet-193	225	32	.	.	PUNCT
admet-193	226	1	measurements	measurement	NOUN
admet-193	226	2	of	of	ADP
admet-193	226	3	ph	ph	NOUN
admet-193	226	4	are	be	AUX
admet-193	226	5	sensitive	sensitive	ADJ
admet-193	226	6	to	to	ADP
admet-193	226	7	ionic	ionic	ADJ
admet-193	226	8	strength	strength	NOUN
admet-193	226	9	effects	effect	NOUN
admet-193	226	10	,	,	PUNCT
admet-193	226	11	especially	especially	ADV
admet-193	226	12	in	in	ADP
admet-193	226	13	poorly	poorly	ADV
admet-193	226	14	buffered	buffer	VERB
admet-193	226	15	solutions	solution	NOUN
admet-193	226	16	.	.	PUNCT
admet-193	227	1	in	in	ADP
admet-193	227	2	measurements	measurement	NOUN
admet-193	227	3	of	of	ADP
admet-193	227	4	salt	salt	NOUN
admet-193	227	5	solubility	solubility	NOUN
admet-193	227	6	,	,	PUNCT
admet-193	227	7	it	it	PRON
admet-193	227	8	is	be	AUX
admet-193	227	9	not	not	PART
admet-193	227	10	uncommon	uncommon	ADJ
admet-193	227	11	to	to	PART
admet-193	227	12	have	have	VERB
admet-193	227	13	the	the	DET
admet-193	227	14	ionic	ionic	ADJ
admet-193	227	15	strength	strength	NOUN
admet-193	227	16	reach	reach	VERB
admet-193	227	17	1	1	NUM
admet-193	227	18	-	-	SYM
admet-193	227	19	3	3	NUM
admet-193	227	20	m.	m.	NOUN
admet-193	227	21	methods	method	NOUN
admet-193	227	22	for	for	ADP
admet-193	227	23	electrode	electrode	ADJ
admet-193	227	24	calibration	calibration	NOUN
admet-193	227	25	to	to	PART
admet-193	227	26	address	address	VERB
admet-193	227	27	these	these	DET
admet-193	227	28	challenging	challenging	ADJ
admet-193	227	29	conditions	condition	NOUN
admet-193	227	30	have	have	AUX
admet-193	227	31	been	be	AUX
admet-193	227	32	discussed	discuss	VERB
admet-193	227	33	in	in	ADP
admet-193	227	34	the	the	DET
admet-193	227	35	literature	literature	NOUN
admet-193	227	36	(	(	PUNCT
admet-193	227	37	völgyi	völgyi	NOUN
admet-193	227	38	et	et	PROPN
admet-193	227	39	al	al	PROPN
admet-193	227	40	.	.	PUNCT
admet-193	228	1	[	[	X
admet-193	228	2	32	32	NUM
admet-193	228	3	]	]	PUNCT
admet-193	228	4	;	;	PUNCT
admet-193	228	5	wang	wang	PROPN
admet-193	228	6	et	et	PROPN
admet-193	228	7	al	al	PROPN
admet-193	228	8	.	.	PUNCT
admet-193	229	1	[	[	X
admet-193	229	2	56	56	NUM
admet-193	229	3	]	]	PUNCT
admet-193	229	4	)	)	PUNCT
admet-193	229	5	.	.	PUNCT
admet-193	230	1	errors	error	NOUN
admet-193	230	2	in	in	ADP
admet-193	230	3	the	the	DET
admet-193	230	4	ph	ph	ADJ
admet-193	230	5	scale	scale	NOUN
admet-193	230	6	can	can	AUX
admet-193	230	7	easily	easily	ADV
admet-193	230	8	exceed	exceed	VERB
admet-193	230	9	0.1	0.1	NUM
admet-193	230	10	-	-	PUNCT
admet-193	230	11	0.2	0.2	NUM
admet-193	230	12	units	unit	NOUN
admet-193	230	13	in	in	ADP
admet-193	230	14	the	the	DET
admet-193	230	15	mid	mid	ADJ
admet-193	230	16	-	-	ADJ
admet-193	230	17	scale	scale	ADJ
admet-193	230	18	region	region	NOUN
admet-193	230	19	.	.	PUNCT
admet-193	231	1	for	for	ADP
admet-193	231	2	measurements	measurement	NOUN
admet-193	231	3	at	at	ADP
admet-193	231	4	ph	ph	NOUN
admet-193	231	5	<	<	X
admet-193	231	6	1	1	NUM
admet-193	231	7	or	or	CCONJ
admet-193	231	8	ph	ph	ADJ
admet-193	231	9	>	>	X
admet-193	231	10	12	12	NUM
admet-193	231	11	,	,	PUNCT
admet-193	231	12	the	the	DET
admet-193	231	13	ph	ph	ADJ
admet-193	231	14	scale	scale	NOUN
admet-193	231	15	can	can	AUX
admet-193	231	16	be	be	AUX
admet-193	231	17	in	in	ADP
admet-193	231	18	error	error	NOUN
admet-193	231	19	by	by	ADP
admet-193	231	20	as	as	ADV
admet-193	231	21	much	much	ADJ
admet-193	231	22	as	as	ADP
admet-193	231	23	0.5	0.5	NUM
admet-193	231	24	log	log	NOUN
admet-193	231	25	unit	unit	NOUN
admet-193	231	26	.	.	PUNCT
admet-193	232	1	the	the	DET
admet-193	232	2	ph	ph	ADJ
admet-193	232	3	electrode	electrode	NOUN
admet-193	232	4	practices	practice	NOUN
admet-193	232	5	routinely	routinely	ADV
admet-193	232	6	used	use	VERB
admet-193	232	7	in	in	ADP
admet-193	232	8	modern	modern	ADJ
admet-193	232	9	pka	pka	PROPN
admet-193	232	10	methodology	methodology	NOUN
admet-193	232	11	would	would	AUX
admet-193	232	12	benefit	benefit	VERB
admet-193	232	13	solubility	solubility	NOUN
admet-193	232	14	measurement	measurement	NOUN
admet-193	232	15	and	and	CCONJ
admet-193	232	16	lead	lead	VERB
admet-193	232	17	to	to	ADP
admet-193	232	18	improved	improved	ADJ
admet-193	232	19	quality	quality	NOUN
admet-193	232	20	of	of	ADP
admet-193	232	21	results	result	NOUN
admet-193	232	22	.	.	PUNCT
admet-193	233	1	separating	separate	VERB
admet-193	233	2	solid	solid	ADV
admet-193	233	3	from	from	ADP
admet-193	233	4	saturated	saturated	ADJ
admet-193	233	5	solution	solution	NOUN
admet-193	233	6	an	an	DET
admet-193	233	7	advantage	advantage	NOUN
admet-193	233	8	of	of	ADP
admet-193	233	9	the	the	DET
admet-193	233	10	potentiometric	potentiometric	ADJ
admet-193	233	11	methods	method	NOUN
admet-193	233	12	is	be	AUX
admet-193	233	13	that	that	SCONJ
admet-193	233	14	they	they	PRON
admet-193	233	15	do	do	AUX
admet-193	233	16	not	not	PART
admet-193	233	17	require	require	VERB
admet-193	233	18	phase	phase	NOUN
admet-193	233	19	separation	separation	NOUN
admet-193	233	20	.	.	PUNCT
admet-193	234	1	also	also	ADV
admet-193	234	2	,	,	PUNCT
admet-193	234	3	certain	certain	ADJ
admet-193	234	4	fiber	fiber	NOUN
admet-193	234	5	optic	optic	NOUN
admet-193	234	6	probe	probe	NOUN
admet-193	234	7	methods	method	NOUN
admet-193	234	8	can	can	AUX
admet-193	234	9	determine	determine	VERB
admet-193	234	10	concentrations	concentration	NOUN
admet-193	234	11	in	in	ADP
admet-193	234	12	turbid	turbid	ADJ
admet-193	234	13	solutions	solution	NOUN
admet-193	234	14	(	(	PUNCT
admet-193	234	15	cf	cf	NOUN
admet-193	234	16	.	.	NOUN
admet-193	234	17	,	,	PUNCT
admet-193	234	18	appendix	appendix	NOUN
admet-193	234	19	)	)	PUNCT
admet-193	234	20	.	.	PUNCT
admet-193	235	1	however	however	ADV
admet-193	235	2	,	,	PUNCT
admet-193	235	3	most	most	ADV
admet-193	235	4	traditional	traditional	ADJ
admet-193	235	5	methods	method	NOUN
admet-193	235	6	require	require	VERB
admet-193	235	7	some	some	DET
admet-193	235	8	sort	sort	NOUN
admet-193	235	9	of	of	ADP
admet-193	235	10	phase	phase	NOUN
admet-193	235	11	separation	separation	NOUN
admet-193	235	12	.	.	PUNCT
admet-193	236	1	of	of	ADP
admet-193	236	2	the	the	DET
admet-193	236	3	4557	4557	NUM
admet-193	236	4	entries	entry	NOUN
admet-193	236	5	in	in	ADP
admet-193	236	6	database	database	NOUN
admet-193	236	7	,	,	PUNCT
admet-193	236	8	there	there	PRON
admet-193	236	9	were	be	VERB
admet-193	236	10	only	only	ADV
admet-193	236	11	583	583	NUM
admet-193	236	12	indications	indication	NOUN
admet-193	236	13	of	of	ADP
admet-193	236	14	the	the	DET
admet-193	236	15	type	type	NOUN
admet-193	236	16	of	of	ADP
admet-193	236	17	phase	phase	NOUN
admet-193	236	18	separation	separation	NOUN
admet-193	236	19	used	use	VERB
admet-193	236	20	.	.	PUNCT
admet-193	237	1	it	it	PRON
admet-193	237	2	’s	’	VERB
admet-193	237	3	surprising	surprising	ADJ
admet-193	237	4	that	that	SCONJ
admet-193	237	5	not	not	PART
admet-193	237	6	all	all	DET
admet-193	237	7	primary	primary	ADJ
admet-193	237	8	sources	source	NOUN
admet-193	237	9	identified	identify	VERB
admet-193	237	10	the	the	DET
admet-193	237	11	means	mean	NOUN
admet-193	237	12	of	of	ADP
admet-193	237	13	separation	separation	NOUN
admet-193	237	14	,	,	PUNCT
admet-193	237	15	although	although	SCONJ
admet-193	237	16	one	one	PRON
admet-193	237	17	might	might	AUX
admet-193	237	18	surmise	surmise	VERB
admet-193	237	19	that	that	SCONJ
admet-193	237	20	most	most	ADJ
admet-193	237	21	of	of	ADP
admet-193	237	22	these	these	DET
admet-193	237	23	employed	employ	VERB
admet-193	237	24	filtration	filtration	NOUN
admet-193	237	25	.	.	PUNCT
admet-193	238	1	none	none	NOUN
admet-193	238	2	of	of	ADP
admet-193	238	3	the	the	DET
admet-193	238	4	secondary	secondary	ADJ
admet-193	238	5	sources	source	NOUN
admet-193	238	6	lists	list	VERB
admet-193	238	7	such	such	ADJ
admet-193	238	8	detail	detail	NOUN
admet-193	238	9	.	.	PUNCT
admet-193	239	1	of	of	ADP
admet-193	239	2	the	the	DET
admet-193	239	3	indicated	indicate	VERB
admet-193	239	4	values	value	NOUN
admet-193	239	5	,	,	PUNCT
admet-193	239	6	44	44	NUM
admet-193	239	7	%	%	NOUN
admet-193	239	8	used	use	VERB
admet-193	239	9	some	some	DET
admet-193	239	10	means	mean	NOUN
admet-193	239	11	of	of	ADP
admet-193	239	12	filtration	filtration	NOUN
admet-193	239	13	,	,	PUNCT
admet-193	239	14	14	14	NUM
admet-193	239	15	%	%	NOUN
admet-193	239	16	used	use	VERB
admet-193	239	17	centrifugation	centrifugation	NOUN
admet-193	239	18	,	,	PUNCT
admet-193	239	19	and	and	CCONJ
admet-193	239	20	9	9	NUM
admet-193	239	21	%	%	NOUN
admet-193	239	22	used	use	VERB
admet-193	239	23	sedimentation	sedimentation	NOUN
admet-193	239	24	solely	solely	ADV
admet-193	239	25	.	.	PUNCT
admet-193	240	1	the	the	DET
admet-193	240	2	majority	majority	NOUN
admet-193	240	3	of	of	ADP
admet-193	240	4	those	those	PRON
admet-193	240	5	using	use	VERB
admet-193	240	6	filtration	filtration	NOUN
admet-193	240	7	seemed	seem	VERB
admet-193	240	8	to	to	PART
admet-193	240	9	be	be	AUX
admet-193	240	10	aware	aware	ADJ
admet-193	240	11	of	of	ADP
admet-193	240	12	the	the	DET
admet-193	240	13	problem	problem	NOUN
admet-193	240	14	of	of	ADP
admet-193	240	15	filter	filter	NOUN
admet-193	240	16	adsorption	adsorption	NOUN
admet-193	240	17	and	and	CCONJ
admet-193	240	18	discarded	discard	VERB
admet-193	240	19	the	the	DET
admet-193	240	20	initial	initial	ADJ
admet-193	240	21	filtrate	filtrate	ADJ
admet-193	240	22	solution	solution	NOUN
admet-193	240	23	or	or	CCONJ
admet-193	240	24	performed	perform	VERB
admet-193	240	25	“	"	PUNCT
admet-193	240	26	double	double	ADJ
admet-193	240	27	filtration	filtration	NOUN
admet-193	240	28	”	"	PUNCT
admet-193	241	1	[	[	X
admet-193	241	2	52,57	52,57	NOUN
admet-193	241	3	]	]	PUNCT
admet-193	241	4	.	.	PUNCT
admet-193	242	1	a	a	DET
admet-193	242	2	few	few	ADJ
admet-193	242	3	of	of	ADP
admet-193	242	4	those	those	PRON
admet-193	242	5	using	use	VERB
admet-193	242	6	filtration	filtration	NOUN
admet-193	242	7	did	do	AUX
admet-193	242	8	not	not	PART
admet-193	242	9	take	take	VERB
admet-193	242	10	heed	heed	NOUN
admet-193	242	11	of	of	ADP
admet-193	242	12	the	the	DET
admet-193	242	13	chen	chen	PROPN
admet-193	242	14	et	et	PROPN
admet-193	242	15	al	al	PROPN
admet-193	242	16	.	.	PUNCT
admet-193	243	1	[	[	X
admet-193	243	2	58	58	NUM
admet-193	243	3	]	]	PUNCT
admet-193	243	4	recommendations	recommendation	NOUN
admet-193	243	5	against	against	ADP
admet-193	243	6	using	use	VERB
admet-193	243	7	nylon	nylon	NOUN
admet-193	243	8	filters	filter	NOUN
admet-193	243	9	.	.	PUNCT
admet-193	244	1	a	a	DET
admet-193	244	2	solid	solid	ADJ
admet-193	244	3	drug	drug	NOUN
admet-193	244	4	substance	substance	NOUN
admet-193	244	5	in	in	ADP
admet-193	244	6	equilibrium	equilibrium	NOUN
admet-193	244	7	with	with	ADP
admet-193	244	8	its	its	PRON
admet-193	244	9	saturated	saturate	VERB
admet-193	244	10	solution	solution	NOUN
admet-193	244	11	is	be	AUX
admet-193	244	12	dynamically	dynamically	ADV
admet-193	244	13	dissolving	dissolve	VERB
admet-193	244	14	and	and	CCONJ
admet-193	244	15	precipitating	precipitate	VERB
admet-193	244	16	at	at	ADP
admet-193	244	17	equal	equal	ADJ
admet-193	244	18	rates	rate	NOUN
admet-193	244	19	.	.	PUNCT
admet-193	245	1	since	since	SCONJ
admet-193	245	2	that	that	DET
admet-193	245	3	equilibrium	equilibrium	NOUN
admet-193	245	4	is	be	AUX
admet-193	245	5	maintained	maintain	VERB
admet-193	245	6	by	by	ADP
admet-193	245	7	the	the	DET
admet-193	245	8	presence	presence	NOUN
admet-193	245	9	of	of	ADP
admet-193	245	10	the	the	DET
admet-193	245	11	solid	solid	ADJ
admet-193	245	12	,	,	PUNCT
admet-193	245	13	the	the	DET
admet-193	245	14	act	act	NOUN
admet-193	245	15	of	of	ADP
admet-193	245	16	separation	separation	NOUN
admet-193	245	17	by	by	ADP
admet-193	245	18	filtration	filtration	NOUN
admet-193	245	19	disrupts	disrupt	VERB
admet-193	245	20	the	the	DET
admet-193	245	21	process	process	NOUN
admet-193	245	22	,	,	PUNCT
admet-193	245	23	to	to	ADP
admet-193	245	24	the	the	DET
admet-193	245	25	extent	extent	NOUN
admet-193	245	26	that	that	SCONJ
admet-193	245	27	the	the	DET
admet-193	245	28	solution	solution	NOUN
admet-193	245	29	concentrations	concentration	NOUN
admet-193	245	30	may	may	AUX
admet-193	245	31	be	be	AUX
admet-193	245	32	altered	alter	VERB
admet-193	245	33	by	by	ADP
admet-193	245	34	reactions	reaction	NOUN
admet-193	245	35	of	of	ADP
admet-193	245	36	the	the	DET
admet-193	245	37	substance	substance	NOUN
admet-193	245	38	with	with	ADP
admet-193	245	39	the	the	DET
admet-193	245	40	container	container	NOUN
admet-193	245	41	and	and	CCONJ
admet-193	245	42	filter	filter	NOUN
admet-193	245	43	surfaces	surface	NOUN
admet-193	245	44	.	.	PUNCT
admet-193	246	1	thus	thus	ADV
admet-193	246	2	,	,	PUNCT
admet-193	246	3	avoiding	avoid	VERB
admet-193	246	4	filtration	filtration	NOUN
admet-193	246	5	,	,	PUNCT
admet-193	246	6	if	if	SCONJ
admet-193	246	7	possible	possible	ADJ
admet-193	246	8	,	,	PUNCT
admet-193	246	9	can	can	AUX
admet-193	246	10	be	be	AUX
admet-193	246	11	recommended	recommend	VERB
admet-193	246	12	.	.	PUNCT
admet-193	247	1	however	however	ADV
admet-193	247	2	,	,	PUNCT
admet-193	247	3	it	it	PRON
admet-193	247	4	is	be	AUX
admet-193	247	5	such	such	DET
admet-193	247	6	a	a	DET
admet-193	247	7	popular	popular	ADJ
admet-193	247	8	procedure	procedure	NOUN
admet-193	247	9	,	,	PUNCT
admet-193	247	10	that	that	SCONJ
admet-193	247	11	most	most	ADJ
admet-193	247	12	non	non	ADJ
admet-193	247	13	-	-	ADJ
admet-193	247	14	potentiometric	potentiometric	ADJ
admet-193	247	15	protocols	protocol	NOUN
admet-193	247	16	use	use	VERB
admet-193	247	17	it	it	PRON
admet-193	247	18	.	.	PUNCT
admet-193	248	1	especially	especially	ADV
admet-193	248	2	noteworthy	noteworthy	ADJ
admet-193	248	3	,	,	PUNCT
admet-193	248	4	13	13	NUM
admet-193	248	5	%	%	NOUN
admet-193	248	6	of	of	ADP
admet-193	248	7	separations	separation	NOUN
admet-193	248	8	were	be	AUX
admet-193	248	9	done	do	VERB
admet-193	248	10	by	by	ADP
admet-193	248	11	centrifugation	centrifugation	NOUN
admet-193	248	12	,	,	PUNCT
admet-193	248	13	followed	follow	VERB
admet-193	248	14	by	by	ADP
admet-193	248	15	filtration	filtration	NOUN
admet-193	248	16	.	.	PUNCT
admet-193	249	1	this	this	PRON
admet-193	249	2	can	can	AUX
admet-193	249	3	be	be	AUX
admet-193	249	4	problematic	problematic	ADJ
admet-193	249	5	with	with	ADP
admet-193	249	6	low	low	ADJ
admet-193	249	7	soluble	soluble	ADJ
admet-193	249	8	compounds	compound	NOUN
admet-193	249	9	,	,	PUNCT
admet-193	249	10	for	for	ADP
admet-193	249	11	the	the	DET
admet-193	249	12	above	above	ADJ
admet-193	249	13	reasons	reason	NOUN
admet-193	249	14	.	.	PUNCT
admet-193	250	1	if	if	SCONJ
admet-193	250	2	a	a	DET
admet-193	250	3	saturated	saturate	VERB
admet-193	250	4	solution	solution	NOUN
admet-193	250	5	is	be	AUX
admet-193	250	6	devoid	devoid	ADJ
admet-193	250	7	of	of	ADP
admet-193	250	8	excess	excess	ADJ
admet-193	250	9	solid	solid	ADJ
admet-193	250	10	(	(	PUNCT
admet-193	250	11	which	which	DET
admet-193	250	12	centrifugation	centrifugation	NOUN
admet-193	250	13	removes	remove	VERB
admet-193	250	14	)	)	PUNCT
admet-193	250	15	,	,	PUNCT
admet-193	250	16	then	then	ADV
admet-193	250	17	passing	pass	VERB
admet-193	250	18	the	the	DET
admet-193	250	19	weakly	weakly	ADV
admet-193	250	20	-	-	PUNCT
admet-193	250	21	poised	poise	VERB
admet-193	250	22	(	(	PUNCT
admet-193	250	23	i.e.	i.e.	X
admet-193	250	24	,	,	PUNCT
admet-193	250	25	nearly	nearly	ADV
admet-193	250	26	subsaturated	subsaturate	VERB
admet-193	250	27	)	)	PUNCT
admet-193	250	28	solution	solution	NOUN
admet-193	250	29	through	through	ADP
admet-193	250	30	a	a	DET
admet-193	250	31	filter	filter	NOUN
admet-193	250	32	can	can	AUX
admet-193	250	33	produce	produce	VERB
admet-193	250	34	a	a	DET
admet-193	250	35	significantly	significantly	ADV
admet-193	250	36	subsaturated	subsaturate	VERB
admet-193	250	37	solution	solution	NOUN
admet-193	250	38	.	.	PUNCT
admet-193	251	1	vessel	vessel	NOUN
admet-193	251	2	surface	surface	NOUN
admet-193	251	3	adsorption	adsorption	NOUN
admet-193	251	4	may	may	AUX
admet-193	251	5	contribute	contribute	VERB
admet-193	251	6	to	to	ADP
admet-193	251	7	a	a	DET
admet-193	251	8	further	further	ADJ
admet-193	251	9	lowering	lowering	NOUN
admet-193	251	10	of	of	ADP
admet-193	251	11	the	the	DET
admet-193	251	12	amount	amount	NOUN
admet-193	251	13	of	of	ADP
admet-193	251	14	dissolved	dissolved	ADJ
admet-193	251	15	sample	sample	NOUN
admet-193	251	16	.	.	PUNCT
admet-193	252	1	in	in	ADP
admet-193	252	2	such	such	DET
admet-193	252	3	a	a	DET
admet-193	252	4	combined	combined	ADJ
admet-193	252	5	procedure	procedure	NOUN
admet-193	252	6	,	,	PUNCT
admet-193	252	7	solubility	solubility	NOUN
admet-193	252	8	may	may	AUX
admet-193	252	9	be	be	AUX
admet-193	252	10	significantly	significantly	ADV
admet-193	252	11	underestimated	underestimate	VERB
admet-193	252	12	.	.	PUNCT
admet-193	253	1	the	the	DET
admet-193	253	2	above	above	ADJ
admet-193	253	3	practice	practice	NOUN
admet-193	253	4	is	be	AUX
admet-193	253	5	best	well	ADV
admet-193	253	6	avoided	avoid	VERB
admet-193	253	7	,	,	PUNCT
admet-193	253	8	especially	especially	ADV
admet-193	253	9	with	with	ADP
admet-193	253	10	low	low	ADJ
admet-193	253	11	soluble	soluble	ADJ
admet-193	253	12	compounds	compound	NOUN
admet-193	253	13	.	.	PUNCT
admet-193	254	1	avdeef	avdeef	PROPN
admet-193	254	2	admet	admet	PROPN
admet-193	254	3	&	&	CCONJ
admet-193	254	4	dmpk	dmpk	PROPN
admet-193	254	5	3(2	3(2	NUM
admet-193	254	6	)	)	PUNCT
admet-193	254	7	(	(	PUNCT
admet-193	254	8	2015	2015	NUM
admet-193	254	9	)	)	PUNCT
admet-193	254	10	84	84	NUM
admet-193	254	11	-	-	SYM
admet-193	254	12	109	109	NUM
admet-193	254	13	94	94	NUM
admet-193	254	14	figure	figure	NOUN
admet-193	254	15	3	3	NUM
admet-193	254	16	.	.	NOUN
admet-193	254	17	comparison	comparison	NOUN
admet-193	254	18	of	of	ADP
admet-193	254	19	traditional	traditional	ADJ
admet-193	254	20	shake	shake	NOUN
admet-193	254	21	-	-	PUNCT
admet-193	254	22	flask	flask	NOUN
admet-193	254	23	measurements	measurement	NOUN
admet-193	254	24	to	to	ADP
admet-193	254	25	(	(	PUNCT
admet-193	254	26	a	a	X
admet-193	254	27	)	)	PUNCT
admet-193	254	28	the	the	DET
admet-193	254	29	dissolution	dissolution	NOUN
admet-193	254	30	template	template	NOUN
admet-193	254	31	titration	titration	NOUN
admet-193	254	32	(	(	PUNCT
admet-193	254	33	dtt	dtt	NOUN
admet-193	254	34	)	)	PUNCT
admet-193	254	35	potentiometric	potentiometric	ADJ
admet-193	254	36	method	method	NOUN
admet-193	254	37	,	,	PUNCT
admet-193	254	38	(	(	PUNCT
admet-193	254	39	b	b	X
admet-193	254	40	)	)	PUNCT
admet-193	254	41	the	the	DET
admet-193	254	42	cheqsol	cheqsol	ADJ
admet-193	254	43	potentiometric	potentiometric	ADJ
admet-193	254	44	method	method	NOUN
admet-193	254	45	,	,	PUNCT
admet-193	254	46	and	and	CCONJ
admet-193	254	47	(	(	PUNCT
admet-193	254	48	c	c	X
admet-193	254	49	)	)	PUNCT
admet-193	254	50	the	the	DET
admet-193	254	51	shake	shake	NOUN
admet-193	254	52	-	-	PUNCT
admet-193	254	53	flask	flask	NOUN
admet-193	254	54	method	method	NOUN
admet-193	254	55	done	do	VERB
admet-193	254	56	in	in	ADP
admet-193	254	57	one	one	NUM
admet-193	254	58	laboratory	laboratory	NOUN
admet-193	254	59	using	use	VERB
admet-193	254	60	the	the	DET
admet-193	254	61	same	same	ADJ
admet-193	254	62	protocol	protocol	NOUN
admet-193	254	63	.	.	PUNCT
admet-193	255	1	centrifugation	centrifugation	NOUN
admet-193	255	2	is	be	AUX
admet-193	255	3	needed	need	VERB
admet-193	255	4	in	in	ADP
admet-193	255	5	cases	case	NOUN
admet-193	255	6	of	of	ADP
admet-193	255	7	samples	sample	NOUN
admet-193	255	8	that	that	PRON
admet-193	255	9	form	form	NOUN
admet-193	255	10	(	(	PUNCT
admet-193	255	11	a	a	PRON
admet-193	255	12	)	)	PUNCT
admet-193	255	13	opalescent	opalescent	NOUN
admet-193	255	14	saturated	saturate	VERB
admet-193	255	15	solutions	solution	NOUN
admet-193	255	16	(	(	PUNCT
admet-193	255	17	e.g.	e.g.	ADV
admet-193	255	18	,	,	PUNCT
admet-193	255	19	colloid	colloid	NOUN
admet-193	255	20	systems	system	NOUN
admet-193	255	21	)	)	PUNCT
admet-193	255	22	,	,	PUNCT
admet-193	255	23	or	or	CCONJ
admet-193	255	24	(	(	PUNCT
admet-193	255	25	b	b	NOUN
admet-193	255	26	)	)	PUNCT
admet-193	255	27	stable	stable	ADJ
admet-193	255	28	suspensions	suspension	NOUN
admet-193	255	29	that	that	PRON
admet-193	255	30	do	do	AUX
admet-193	255	31	not	not	PART
admet-193	255	32	sediment	sediment	VERB
admet-193	255	33	easily	easily	ADV
admet-193	255	34	,	,	PUNCT
admet-193	255	35	or	or	CCONJ
admet-193	255	36	(	(	PUNCT
admet-193	255	37	c	c	NOUN
admet-193	255	38	)	)	PUNCT
admet-193	255	39	small	small	ADJ
admet-193	255	40	agglomerate	agglomerate	NOUN
admet-193	255	41	particulates	particulate	NOUN
admet-193	255	42	that	that	PRON
admet-193	255	43	can	can	AUX
admet-193	255	44	pass	pass	VERB
admet-193	255	45	through	through	ADP
admet-193	255	46	commonly	commonly	ADV
admet-193	255	47	-	-	PUNCT
admet-193	255	48	used	use	VERB
admet-193	255	49	filtration	filtration	NOUN
admet-193	255	50	membranes	membrane	NOUN
admet-193	255	51	.	.	PUNCT
admet-193	256	1	it	it	PRON
admet-193	256	2	was	be	AUX
admet-193	256	3	shown	show	VERB
admet-193	256	4	by	by	ADP
admet-193	256	5	mcgovern	mcgovern	PROPN
admet-193	256	6	et	et	PROPN
admet-193	256	7	al	al	PROPN
admet-193	256	8	.	.	PUNCT
admet-193	257	1	[	[	X
admet-193	257	2	59	59	NUM
admet-193	257	3	]	]	PUNCT
admet-193	257	4	that	that	SCONJ
admet-193	257	5	certain	certain	ADJ
admet-193	257	6	types	type	NOUN
admet-193	257	7	of	of	ADP
admet-193	257	8	low	low	ADJ
admet-193	257	9	soluble	soluble	ADJ
admet-193	257	10	research	research	NOUN
admet-193	257	11	compounds	compound	NOUN
admet-193	257	12	,	,	PUNCT
admet-193	257	13	dubbed	dub	VERB
admet-193	257	14	“	"	PUNCT
admet-193	257	15	promiscuous	promiscuous	ADJ
admet-193	257	16	inhibitors	inhibitor	NOUN
admet-193	257	17	,	,	PUNCT
admet-193	257	18	”	"	PUNCT
admet-193	257	19	form	form	NOUN
admet-193	257	20	agglomerates	agglomerate	NOUN
admet-193	257	21	of	of	ADP
admet-193	257	22	the	the	DET
admet-193	257	23	order	order	NOUN
admet-193	257	24	of	of	ADP
admet-193	257	25	0.1	0.1	NUM
admet-193	257	26	μm	μm	NOUN
admet-193	257	27	in	in	ADP
admet-193	257	28	size	size	NOUN
admet-193	257	29	.	.	PUNCT
admet-193	258	1	these	these	PRON
admet-193	258	2	can	can	AUX
admet-193	258	3	pass	pass	VERB
admet-193	258	4	through	through	ADP
admet-193	258	5	most	most	ADJ
admet-193	258	6	filters	filter	NOUN
admet-193	258	7	used	use	VERB
admet-193	258	8	for	for	ADP
admet-193	258	9	phase	phase	NOUN
admet-193	258	10	separation	separation	NOUN
admet-193	258	11	,	,	PUNCT
admet-193	258	12	leading	lead	VERB
admet-193	258	13	to	to	ADP
admet-193	258	14	overestimates	overestimate	NOUN
admet-193	258	15	of	of	ADP
admet-193	258	16	the	the	DET
admet-193	258	17	solubility	solubility	NOUN
admet-193	258	18	.	.	PUNCT
admet-193	259	1	if	if	SCONJ
admet-193	259	2	such	such	ADJ
admet-193	259	3	compounds	compound	NOUN
admet-193	259	4	are	be	AUX
admet-193	259	5	suspected	suspect	VERB
admet-193	259	6	,	,	PUNCT
admet-193	259	7	it	it	PRON
admet-193	259	8	may	may	AUX
admet-193	259	9	be	be	AUX
admet-193	259	10	a	a	DET
admet-193	259	11	useful	useful	ADJ
admet-193	259	12	first	first	ADV
admet-193	259	13	to	to	PART
admet-193	259	14	filter	filter	VERB
admet-193	259	15	the	the	DET
admet-193	259	16	suspension	suspension	NOUN
admet-193	259	17	and	and	CCONJ
admet-193	259	18	then	then	ADV
admet-193	259	19	to	to	PART
admet-193	259	20	ultracentrifuge	ultracentrifuge	VERB
admet-193	259	21	it	it	PRON
admet-193	259	22	(	(	PUNCT
admet-193	259	23	in	in	ADP
admet-193	259	24	that	that	DET
admet-193	259	25	order	order	NOUN
admet-193	259	26	)	)	PUNCT
admet-193	259	27	.	.	PUNCT
admet-193	260	1	equilibration	equilibration	NOUN
admet-193	260	2	time	time	NOUN
admet-193	260	3	and	and	CCONJ
admet-193	260	4	identifying	identify	VERB
admet-193	260	5	the	the	DET
admet-193	260	6	final	final	ADJ
admet-193	260	7	form	form	NOUN
admet-193	260	8	of	of	ADP
admet-193	260	9	the	the	DET
admet-193	260	10	solid	solid	NOUN
admet-193	260	11	in	in	ADP
admet-193	260	12	the	the	DET
admet-193	260	13	saturated	saturate	VERB
admet-193	260	14	solution	solution	NOUN
admet-193	260	15	most	most	ADJ
admet-193	260	16	of	of	ADP
admet-193	260	17	the	the	DET
admet-193	260	18	equilibrium	equilibrium	NOUN
admet-193	260	19	protocols	protocol	NOUN
admet-193	260	20	reviewed	review	VERB
admet-193	260	21	here	here	ADV
admet-193	260	22	strive	strive	VERB
admet-193	260	23	to	to	PART
admet-193	260	24	determine	determine	VERB
admet-193	260	25	the	the	DET
admet-193	260	26	solubility	solubility	NOUN
admet-193	260	27	of	of	ADP
admet-193	260	28	the	the	DET
admet-193	260	29	most	most	ADV
admet-193	260	30	stable	stable	ADJ
admet-193	260	31	form	form	NOUN
admet-193	260	32	of	of	ADP
admet-193	260	33	the	the	DET
admet-193	260	34	solid	solid	ADJ
admet-193	260	35	,	,	PUNCT
admet-193	260	36	most	most	ADV
admet-193	260	37	likely	likely	ADJ
admet-193	260	38	crystalline	crystalline	NOUN
admet-193	260	39	(	(	PUNCT
admet-193	260	40	and	and	CCONJ
admet-193	260	41	sometimes	sometimes	ADV
admet-193	260	42	hydrated	hydrated	ADJ
admet-193	260	43	)	)	PUNCT
admet-193	260	44	.	.	PUNCT
admet-193	261	1	assay	assay	PROPN
admet-193	261	2	times	time	NOUN
admet-193	261	3	are	be	AUX
admet-193	261	4	selected	select	VERB
admet-193	261	5	to	to	PART
admet-193	261	6	be	be	AUX
admet-193	261	7	long	long	ADV
admet-193	261	8	enough	enough	ADV
admet-193	261	9	to	to	PART
admet-193	261	10	ensure	ensure	VERB
admet-193	261	11	that	that	SCONJ
admet-193	261	12	the	the	DET
admet-193	261	13	measured	measured	ADJ
admet-193	261	14	solubility	solubility	NOUN
admet-193	261	15	is	be	AUX
admet-193	261	16	no	no	ADV
admet-193	261	17	longer	long	ADV
admet-193	261	18	changing	change	VERB
admet-193	261	19	and	and	CCONJ
admet-193	261	20	that	that	SCONJ
admet-193	261	21	it	it	PRON
admet-193	261	22	has	have	AUX
admet-193	261	23	reached	reach	VERB
admet-193	261	24	its	its	PRON
admet-193	261	25	lowest	low	ADJ
admet-193	261	26	value	value	NOUN
admet-193	261	27	.	.	PUNCT
admet-193	262	1	it	it	PRON
admet-193	262	2	is	be	AUX
admet-193	262	3	a	a	DET
admet-193	262	4	common	common	ADJ
admet-193	262	5	practice	practice	NOUN
admet-193	262	6	in	in	ADP
admet-193	262	7	pharmaceutical	pharmaceutical	ADJ
admet-193	262	8	research	research	NOUN
admet-193	262	9	to	to	PART
admet-193	262	10	adopt	adopt	VERB
admet-193	262	11	24	24	NUM
admet-193	262	12	h	h	NOUN
admet-193	262	13	for	for	ADP
admet-193	262	14	the	the	DET
admet-193	262	15	equilibration	equilibration	NOUN
admet-193	262	16	time	time	NOUN
admet-193	262	17	(	(	PUNCT
admet-193	262	18	“	"	PUNCT
admet-193	262	19	one	one	NUM
admet-193	262	20	-	-	PUNCT
admet-193	262	21	shoe	shoe	NOUN
admet-193	262	22	-	-	PUNCT
admet-193	262	23	size	size	NOUN
admet-193	262	24	-	-	PUNCT
admet-193	262	25	fits	fit	VERB
admet-193	262	26	-	-	PUNCT
admet-193	262	27	all	all	PRON
admet-193	262	28	”	"	PUNCT
admet-193	262	29	approach	approach	NOUN
admet-193	262	30	)	)	PUNCT
admet-193	262	31	.	.	PUNCT
admet-193	263	1	in	in	ADP
admet-193	263	2	most	most	ADJ
admet-193	263	3	cases	case	NOUN
admet-193	263	4	,	,	PUNCT
admet-193	263	5	24	24	NUM
admet-193	263	6	h	h	NOUN
admet-193	263	7	is	be	AUX
admet-193	263	8	enough	enough	ADJ
admet-193	263	9	,	,	PUNCT
admet-193	263	10	but	but	CCONJ
admet-193	263	11	certain	certain	ADJ
admet-193	263	12	practically	practically	ADV
admet-193	263	13	-	-	PUNCT
admet-193	263	14	insoluble	insoluble	ADJ
admet-193	263	15	compounds	compound	NOUN
admet-193	263	16	,	,	PUNCT
admet-193	263	17	which	which	PRON
admet-193	263	18	consequently	consequently	ADV
admet-193	263	19	have	have	VERB
admet-193	263	20	very	very	ADV
admet-193	263	21	slow	slow	ADJ
admet-193	263	22	dissolution	dissolution	NOUN
admet-193	263	23	rates	rate	NOUN
admet-193	263	24	may	may	AUX
admet-193	263	25	require	require	VERB
admet-193	263	26	much	much	ADV
admet-193	263	27	longer	long	ADJ
admet-193	263	28	times	time	NOUN
admet-193	264	1	[	[	X
admet-193	264	2	34	34	NUM
admet-193	264	3	]	]	PUNCT
admet-193	264	4	.	.	PUNCT
admet-193	265	1	loftsson	loftsson	NOUN
admet-193	265	2	et	et	PROPN
admet-193	265	3	al	al	PROPN
admet-193	265	4	.	.	PUNCT
admet-193	266	1	[	[	X
admet-193	266	2	60	60	NUM
admet-193	266	3	]	]	PUNCT
admet-193	266	4	allowed	allow	VERB
admet-193	266	5	3	3	NUM
admet-193	266	6	-	-	SYM
admet-193	266	7	7	7	NUM
admet-193	266	8	days	day	NOUN
admet-193	266	9	for	for	ADP
admet-193	266	10	equilibration	equilibration	NOUN
admet-193	266	11	to	to	PART
admet-193	266	12	be	be	AUX
admet-193	266	13	reached	reach	VERB
admet-193	266	14	for	for	ADP
admet-193	266	15	a	a	DET
admet-193	266	16	variety	variety	NOUN
admet-193	266	17	of	of	ADP
admet-193	266	18	low	low	ADJ
admet-193	266	19	soluble	soluble	ADJ
admet-193	266	20	compounds	compound	NOUN
admet-193	266	21	.	.	PUNCT
admet-193	267	1	other	other	ADJ
admet-193	267	2	researchers	researcher	NOUN
admet-193	267	3	used	use	VERB
admet-193	267	4	2	2	NUM
admet-193	267	5	-	-	SYM
admet-193	267	6	10	10	NUM
admet-193	267	7	days	day	NOUN
admet-193	267	8	equilibration	equilibration	NOUN
admet-193	267	9	times	time	NOUN
admet-193	267	10	for	for	ADP
admet-193	267	11	practically	practically	ADV
admet-193	267	12	-	-	PUNCT
admet-193	267	13	insoluble	insoluble	ADJ
admet-193	267	14	anticancer	anticancer	NOUN
admet-193	267	15	drugs	drug	NOUN
admet-193	267	16	(	(	PUNCT
admet-193	267	17	venkatesh	venkatesh	PROPN
admet-193	267	18	et	et	PROPN
admet-193	267	19	al	al	PROPN
admet-193	267	20	.	.	PUNCT
admet-193	268	1	[	[	X
admet-193	268	2	61	61	NUM
admet-193	268	3	]	]	PUNCT
admet-193	268	4	;	;	PUNCT
admet-193	268	5	he	he	PRON
admet-193	268	6	et	et	PROPN
admet-193	268	7	al	al	PROPN
admet-193	268	8	.	.	PUNCT
admet-193	269	1	[	[	X
admet-193	269	2	62	62	NUM
admet-193	269	3	]	]	SYM
admet-193	269	4	)	)	PUNCT
admet-193	269	5	.	.	PUNCT
admet-193	270	1	fini	fini	PROPN
admet-193	270	2	et	et	PROPN
admet-193	270	3	al	al	PROPN
admet-193	270	4	.	.	PUNCT
admet-193	271	1	[	[	X
admet-193	271	2	63	63	NUM
admet-193	271	3	]	]	PUNCT
admet-193	271	4	allowed	allow	VERB
admet-193	271	5	diclofenac	diclofenac	ADJ
admet-193	271	6	suspensions	suspension	NOUN
admet-193	271	7	to	to	PART
admet-193	271	8	incubate	incubate	VERB
admet-193	271	9	for	for	ADP
admet-193	271	10	30	30	NUM
admet-193	271	11	days	day	NOUN
admet-193	271	12	.	.	PUNCT
admet-193	272	1	undeniably	undeniably	ADV
admet-193	272	2	,	,	PUNCT
admet-193	272	3	the	the	DET
admet-193	272	4	stability	stability	NOUN
admet-193	272	5	of	of	ADP
admet-193	272	6	the	the	DET
admet-193	272	7	compound	compound	NOUN
admet-193	272	8	needs	need	VERB
admet-193	272	9	to	to	PART
admet-193	272	10	be	be	AUX
admet-193	272	11	verified	verify	VERB
admet-193	272	12	when	when	SCONJ
admet-193	272	13	such	such	ADJ
admet-193	272	14	long	long	ADJ
admet-193	272	15	times	time	NOUN
admet-193	272	16	are	be	AUX
admet-193	272	17	used	use	VERB
admet-193	272	18	.	.	PUNCT
admet-193	273	1	all	all	ADV
admet-193	273	2	too	too	ADV
admet-193	273	3	often	often	ADV
admet-193	273	4	,	,	PUNCT
admet-193	273	5	at	at	ADP
admet-193	273	6	the	the	DET
admet-193	273	7	end	end	NOUN
admet-193	273	8	of	of	ADP
admet-193	273	9	equilibration	equilibration	NOUN
admet-193	273	10	,	,	PUNCT
admet-193	273	11	the	the	DET
admet-193	273	12	actual	actual	ADJ
admet-193	273	13	form	form	NOUN
admet-193	273	14	of	of	ADP
admet-193	273	15	the	the	DET
admet-193	273	16	solid	solid	NOUN
admet-193	273	17	is	be	AUX
admet-193	273	18	not	not	PART
admet-193	273	19	characterized	characterize	VERB
admet-193	273	20	in	in	ADP
admet-193	273	21	reported	report	VERB
admet-193	273	22	studies	study	NOUN
admet-193	273	23	.	.	PUNCT
admet-193	274	1	often	often	ADV
admet-193	274	2	the	the	DET
admet-193	274	3	monoor	monoor	ADJ
admet-193	274	4	dihydrate	dihydrate	NOUN
admet-193	274	5	is	be	AUX
admet-193	274	6	more	more	ADV
admet-193	274	7	stable	stable	ADJ
admet-193	274	8	(	(	PUNCT
admet-193	274	9	i.e.	i.e.	X
admet-193	274	10	,	,	PUNCT
admet-193	274	11	less	less	ADV
admet-193	274	12	soluble	soluble	ADJ
admet-193	274	13	)	)	PUNCT
admet-193	274	14	than	than	ADP
admet-193	274	15	the	the	DET
admet-193	274	16	anhydrous	anhydrous	ADJ
admet-193	274	17	form	form	NOUN
admet-193	274	18	of	of	ADP
admet-193	274	19	the	the	DET
admet-193	274	20	solid	solid	NOUN
admet-193	274	21	.	.	PUNCT
admet-193	275	1	sometimes	sometimes	ADV
admet-193	275	2	,	,	PUNCT
admet-193	275	3	multiple	multiple	ADJ
admet-193	275	4	-	-	PUNCT
admet-193	275	5	hydrate	hydrate	NOUN
admet-193	275	6	forms	form	NOUN
admet-193	275	7	of	of	ADP
admet-193	275	8	the	the	DET
admet-193	275	9	solid	solid	ADJ
admet-193	275	10	precipitate	precipitate	NOUN
admet-193	275	11	in	in	ADP
admet-193	275	12	the	the	DET
admet-193	275	13	crystalline	crystalline	NOUN
admet-193	275	14	form	form	NOUN
admet-193	275	15	.	.	PUNCT
admet-193	276	1	but	but	CCONJ
admet-193	276	2	this	this	PRON
admet-193	276	3	is	be	AUX
admet-193	276	4	not	not	PART
admet-193	276	5	always	always	ADV
admet-193	276	6	characterized	characterize	VERB
admet-193	276	7	in	in	ADP
admet-193	276	8	published	publish	VERB
admet-193	276	9	solubility	solubility	NOUN
admet-193	276	10	-	-	PUNCT
admet-193	276	11	ph	ph	ADJ
admet-193	276	12	studies	study	NOUN
admet-193	276	13	.	.	PUNCT
admet-193	277	1	admet	admet	PROPN
admet-193	277	2	&	&	CCONJ
admet-193	277	3	dmpk	dmpk	PROPN
admet-193	277	4	3(2	3(2	NUM
admet-193	277	5	)	)	PUNCT
admet-193	277	6	(	(	PUNCT
admet-193	277	7	2015	2015	NUM
admet-193	277	8	)	)	PUNCT
admet-193	277	9	84	84	NUM
admet-193	277	10	-	-	SYM
admet-193	277	11	109	109	NUM
admet-193	277	12	equilibrium	equilibrium	NOUN
admet-193	277	13	solubility	solubility	NOUN
admet-193	277	14	measurements	measurement	NOUN
admet-193	277	15	improvements	improvement	NOUN
admet-193	277	16	doi	doi	NOUN
admet-193	277	17	:	:	PUNCT
admet-193	277	18	10.5599	10.5599	NUM
admet-193	277	19	/	/	SYM
admet-193	277	20	admet.3.2.193	admet.3.2.193	PROPN
admet-193	277	21	95	95	NUM
admet-193	277	22	solvates	solvate	NOUN
admet-193	277	23	aside	aside	ADV
admet-193	277	24	,	,	PUNCT
admet-193	277	25	different	different	ADJ
admet-193	277	26	polymorphs	polymorph	NOUN
admet-193	277	27	of	of	ADP
admet-193	277	28	the	the	DET
admet-193	277	29	same	same	ADJ
admet-193	277	30	stoichiometry	stoichiometry	NOUN
admet-193	277	31	may	may	AUX
admet-193	277	32	form	form	VERB
admet-193	277	33	,	,	PUNCT
admet-193	277	34	depending	depend	VERB
admet-193	277	35	on	on	ADP
admet-193	277	36	the	the	DET
admet-193	277	37	specific	specific	ADJ
admet-193	277	38	assay	assay	NOUN
admet-193	277	39	protocol	protocol	NOUN
admet-193	277	40	.	.	PUNCT
admet-193	278	1	pudipeddi	pudipeddi	NOUN
admet-193	278	2	and	and	CCONJ
admet-193	278	3	serajuddin	serajuddin	VERB
admet-193	278	4	[	[	PUNCT
admet-193	278	5	64	64	NUM
admet-193	278	6	]	]	PUNCT
admet-193	278	7	examined	examine	VERB
admet-193	278	8	the	the	DET
admet-193	278	9	differences	difference	NOUN
admet-193	278	10	between	between	ADP
admet-193	278	11	the	the	DET
admet-193	278	12	solubility	solubility	NOUN
admet-193	278	13	values	value	NOUN
admet-193	278	14	of	of	ADP
admet-193	278	15	polymorphs	polymorph	NOUN
admet-193	278	16	of	of	ADP
admet-193	278	17	various	various	ADJ
admet-193	278	18	substances	substance	NOUN
admet-193	278	19	and	and	CCONJ
admet-193	278	20	found	find	VERB
admet-193	278	21	that	that	SCONJ
admet-193	278	22	0.3	0.3	NUM
admet-193	278	23	log	log	NOUN
admet-193	278	24	unit	unit	NOUN
admet-193	278	25	was	be	AUX
admet-193	278	26	a	a	DET
admet-193	278	27	typical	typical	ADJ
admet-193	278	28	spread	spread	NOUN
admet-193	278	29	.	.	PUNCT
admet-193	279	1	a	a	DET
admet-193	279	2	few	few	ADJ
admet-193	279	3	substances	substance	NOUN
admet-193	279	4	showed	show	VERB
admet-193	279	5	differences	difference	NOUN
admet-193	279	6	as	as	ADV
admet-193	279	7	high	high	ADJ
admet-193	279	8	as	as	ADP
admet-193	279	9	a	a	DET
admet-193	279	10	log	log	NOUN
admet-193	279	11	unit	unit	NOUN
admet-193	279	12	.	.	PUNCT
admet-193	280	1	dl	dl	AUX
admet-193	280	2	-	-	PUNCT
admet-193	280	3	racemates	racemate	NOUN
admet-193	280	4	of	of	ADP
admet-193	280	5	optically	optically	ADV
admet-193	280	6	active	active	ADJ
admet-193	280	7	molecules	molecule	NOUN
admet-193	280	8	can	can	AUX
admet-193	280	9	have	have	VERB
admet-193	280	10	solubilities	solubility	NOUN
admet-193	280	11	lower	low	ADJ
admet-193	280	12	than	than	ADP
admet-193	280	13	those	those	PRON
admet-193	280	14	of	of	ADP
admet-193	280	15	pure	pure	ADJ
admet-193	280	16	enantiomers	enantiomer	NOUN
admet-193	280	17	.	.	PUNCT
admet-193	281	1	for	for	ADP
admet-193	281	2	example	example	NOUN
admet-193	281	3	,	,	PUNCT
admet-193	281	4	at	at	ADP
admet-193	281	5	25	25	NUM
admet-193	281	6	°	°	NOUN
admet-193	281	7	c	c	NOUN
admet-193	281	8	,	,	PUNCT
admet-193	281	9	dl	dl	ADJ
admet-193	281	10	-	-	PUNCT
admet-193	281	11	tartaric	tartaric	ADJ
admet-193	281	12	acid	acid	NOUN
admet-193	281	13	has	have	AUX
admet-193	281	14	log	log	VERB
admet-193	281	15	s0	s0	PROPN
admet-193	281	16	=	=	SYM
admet-193	281	17	+0.18	+0.18	PROPN
admet-193	281	18	,	,	PUNCT
admet-193	281	19	but	but	CCONJ
admet-193	281	20	the	the	DET
admet-193	281	21	l	l	NOUN
admet-193	281	22	-	-	NOUN
admet-193	281	23	form	form	NOUN
admet-193	281	24	has	have	VERB
admet-193	281	25	+0.58	+0.58	PROPN
admet-193	281	26	,	,	PUNCT
admet-193	281	27	an	an	DET
admet-193	281	28	increase	increase	NOUN
admet-193	281	29	of	of	ADP
admet-193	281	30	0.40	0.40	NUM
admet-193	281	31	log	log	NOUN
admet-193	281	32	unit	unit	NOUN
admet-193	281	33	.	.	PUNCT
admet-193	282	1	fourteen	fourteen	NUM
admet-193	282	2	amino	amino	ADJ
admet-193	282	3	acids	acid	NOUN
admet-193	282	4	were	be	AUX
admet-193	282	5	found	find	VERB
admet-193	282	6	with	with	ADP
admet-193	282	7	solubility	solubility	NOUN
admet-193	282	8	values	value	NOUN
admet-193	282	9	reported	report	VERB
admet-193	282	10	for	for	ADP
admet-193	282	11	both	both	CCONJ
admet-193	282	12	the	the	DET
admet-193	282	13	dland	dland	NOUN
admet-193	282	14	lforms	lform	NOUN
admet-193	282	15	.	.	PUNCT
admet-193	283	1	on	on	ADP
admet-193	283	2	the	the	DET
admet-193	283	3	average	average	NOUN
admet-193	283	4	the	the	DET
admet-193	283	5	log	log	NOUN
admet-193	283	6	s0	s0	NOUN
admet-193	283	7	of	of	ADP
admet-193	283	8	the	the	DET
admet-193	283	9	dlenantiomer	dlenantiomer	NOUN
admet-193	283	10	is	be	AUX
admet-193	283	11	0.15	0.15	NUM
admet-193	283	12	lower	low	ADJ
admet-193	283	13	(	(	PUNCT
admet-193	283	14	more	more	ADV
admet-193	283	15	insoluble	insoluble	ADJ
admet-193	283	16	)	)	PUNCT
admet-193	283	17	than	than	ADP
admet-193	283	18	that	that	PRON
admet-193	283	19	of	of	ADP
admet-193	283	20	the	the	DET
admet-193	283	21	lenantiomer	lenantiomer	PROPN
admet-193	283	22	.	.	PUNCT
admet-193	284	1	the	the	DET
admet-193	284	2	least	least	ADV
admet-193	284	3	-	-	PUNCT
admet-193	284	4	soluble	soluble	ADJ
admet-193	284	5	amino	amino	NOUN
admet-193	284	6	acids	acid	NOUN
admet-193	284	7	(	(	PUNCT
admet-193	284	8	tryptophan	tryptophan	NOUN
admet-193	284	9	,	,	PUNCT
admet-193	284	10	tyrosine	tyrosine	NOUN
admet-193	284	11	,	,	PUNCT
admet-193	284	12	and	and	CCONJ
admet-193	284	13	cystine	cystine	NOUN
admet-193	284	14	)	)	PUNCT
admet-193	284	15	show	show	VERB
admet-193	284	16	the	the	DET
admet-193	284	17	largest	large	ADJ
admet-193	284	18	differences	difference	NOUN
admet-193	284	19	in	in	ADP
admet-193	284	20	the	the	DET
admet-193	284	21	solubility	solubility	NOUN
admet-193	284	22	between	between	ADP
admet-193	284	23	the	the	DET
admet-193	284	24	dland	dland	NOUN
admet-193	284	25	the	the	DET
admet-193	284	26	l	l	NOUN
admet-193	284	27	-	-	NOUN
admet-193	284	28	forms	form	NOUN
admet-193	284	29	(	(	PUNCT
admet-193	284	30	i.e.	i.e.	X
admet-193	284	31	,	,	PUNCT
admet-193	284	32	dl	dl	NOUN
admet-193	284	33	-	-	PUNCT
admet-193	284	34	forms	form	NOUN
admet-193	284	35	less	less	ADV
admet-193	284	36	soluble	soluble	ADJ
admet-193	284	37	)	)	PUNCT
admet-193	284	38	.	.	PUNCT
admet-193	285	1	very	very	ADV
admet-193	285	2	few	few	ADJ
admet-193	285	3	chiral	chiral	ADJ
admet-193	285	4	drugs	drug	NOUN
admet-193	285	5	have	have	AUX
admet-193	285	6	both	both	PRON
admet-193	285	7	dland	dland	NOUN
admet-193	285	8	l-/d	l-/d	PROPN
admet-193	285	9	form	form	NOUN
admet-193	285	10	solubilities	solubility	NOUN
admet-193	285	11	reported	report	VERB
admet-193	285	12	.	.	PUNCT
admet-193	286	1	as	as	ADP
admet-193	286	2	an	an	DET
admet-193	286	3	example	example	NOUN
admet-193	286	4	,	,	PUNCT
admet-193	286	5	dl	dl	NOUN
admet-193	286	6	-	-	PUNCT
admet-193	286	7	atropine	atropine	NOUN
admet-193	286	8	has	have	AUX
admet-193	286	9	log	log	VERB
admet-193	286	10	s0	s0	PROPN
admet-193	286	11	=	=	PUNCT
admet-193	286	12	-2.20	-2.20	NUM
admet-193	286	13	±	±	NUM
admet-193	286	14	0.03	0.03	NUM
admet-193	286	15	(	(	PUNCT
admet-193	286	16	n=3	n=3	NOUN
admet-193	286	17	)	)	PUNCT
admet-193	286	18	;	;	PUNCT
admet-193	286	19	l	l	X
admet-193	286	20	-	-	NOUN
admet-193	286	21	atropine	atropine	NOUN
admet-193	286	22	has	have	VERB
admet-193	286	23	-1.84	-1.84	NOUN
admet-193	286	24	±	±	NUM
admet-193	286	25	0.10	0.10	NUM
admet-193	286	26	(	(	PUNCT
admet-193	286	27	n=2	n=2	X
admet-193	286	28	)	)	PUNCT
admet-193	286	29	,	,	PUNCT
admet-193	286	30	an	an	DET
admet-193	286	31	increase	increase	NOUN
admet-193	286	32	of	of	ADP
admet-193	286	33	0.36	0.36	NUM
admet-193	286	34	log	log	NOUN
admet-193	286	35	unit	unit	NOUN
admet-193	286	36	.	.	PUNCT
admet-193	287	1	when	when	SCONJ
admet-193	287	2	solubility	solubility	NOUN
admet-193	287	3	of	of	ADP
admet-193	287	4	chiral	chiral	ADJ
admet-193	287	5	molecules	molecule	NOUN
admet-193	287	6	is	be	AUX
admet-193	287	7	reported	report	VERB
admet-193	287	8	without	without	ADP
admet-193	287	9	mention	mention	NOUN
admet-193	287	10	of	of	ADP
admet-193	287	11	the	the	DET
admet-193	287	12	enantiomeric	enantiomeric	ADJ
admet-193	287	13	state	state	NOUN
admet-193	287	14	,	,	PUNCT
admet-193	287	15	racemic	racemic	ADJ
admet-193	287	16	mixture	mixture	NOUN
admet-193	287	17	is	be	AUX
admet-193	287	18	probably	probably	ADV
admet-193	287	19	implied	imply	VERB
admet-193	287	20	.	.	PUNCT
admet-193	288	1	as	as	SCONJ
admet-193	288	2	mentioned	mention	VERB
admet-193	288	3	above	above	ADV
admet-193	288	4	,	,	PUNCT
admet-193	288	5	in	in	ADP
admet-193	288	6	many	many	ADJ
admet-193	288	7	solubility	solubility	NOUN
admet-193	288	8	studies	study	NOUN
admet-193	288	9	,	,	PUNCT
admet-193	288	10	the	the	DET
admet-193	288	11	solid	solid	ADJ
admet-193	288	12	added	add	VERB
admet-193	288	13	to	to	ADP
admet-193	288	14	solution	solution	NOUN
admet-193	288	15	is	be	AUX
admet-193	288	16	in	in	ADP
admet-193	288	17	the	the	DET
admet-193	288	18	salt	salt	NOUN
admet-193	288	19	form	form	NOUN
admet-193	288	20	(	(	PUNCT
admet-193	288	21	chloride	chloride	NOUN
admet-193	288	22	,	,	PUNCT
admet-193	288	23	maleate	maleate	NOUN
admet-193	288	24	,	,	PUNCT
admet-193	288	25	tartrate	tartrate	NOUN
admet-193	288	26	,	,	PUNCT
admet-193	288	27	sodium	sodium	NOUN
admet-193	288	28	,	,	PUNCT
admet-193	288	29	etc	etc	X
admet-193	288	30	.	.	X
admet-193	288	31	)	)	PUNCT
admet-193	288	32	.	.	PUNCT
admet-193	289	1	the	the	DET
admet-193	289	2	solid	solid	ADJ
admet-193	289	3	that	that	PRON
admet-193	289	4	is	be	AUX
admet-193	289	5	isolated	isolate	VERB
admet-193	289	6	at	at	ADP
admet-193	289	7	the	the	DET
admet-193	289	8	end	end	NOUN
admet-193	289	9	of	of	ADP
admet-193	289	10	equilibration	equilibration	NOUN
admet-193	289	11	may	may	AUX
admet-193	289	12	not	not	PART
admet-193	289	13	be	be	AUX
admet-193	289	14	that	that	PRON
admet-193	289	15	of	of	ADP
admet-193	289	16	the	the	DET
admet-193	289	17	original	original	ADJ
admet-193	289	18	salt	salt	NOUN
admet-193	289	19	form	form	NOUN
admet-193	289	20	,	,	PUNCT
admet-193	289	21	but	but	CCONJ
admet-193	289	22	rather	rather	ADV
admet-193	289	23	of	of	ADP
admet-193	289	24	the	the	DET
admet-193	289	25	free	free	NOUN
admet-193	289	26	-	-	PUNCT
admet-193	289	27	acid/-base	acid/-base	NOUN
admet-193	289	28	.	.	PUNCT
admet-193	290	1	this	this	PRON
admet-193	290	2	can	can	AUX
admet-193	290	3	lead	lead	VERB
admet-193	290	4	to	to	ADP
admet-193	290	5	ambiguity	ambiguity	NOUN
admet-193	290	6	in	in	ADP
admet-193	290	7	ascribing	ascribe	VERB
admet-193	290	8	the	the	DET
admet-193	290	9	reported	report	VERB
admet-193	290	10	solubility	solubility	NOUN
admet-193	290	11	(	(	PUNCT
admet-193	290	12	anderson	anderson	PROPN
admet-193	290	13	and	and	CCONJ
admet-193	290	14	flora	flora	NOUN
admet-193	290	15	[	[	X
admet-193	290	16	65	65	NUM
admet-193	290	17	]	]	NUM
admet-193	290	18	)	)	PUNCT
admet-193	290	19	.	.	PUNCT
admet-193	291	1	consequently	consequently	ADV
admet-193	291	2	,	,	PUNCT
admet-193	291	3	crystal	crystal	NOUN
admet-193	291	4	-	-	PUNCT
admet-193	291	5	form	form	NOUN
admet-193	291	6	uncertainty	uncertainty	NOUN
admet-193	291	7	translates	translate	VERB
admet-193	291	8	to	to	ADP
admet-193	291	9	higher	high	ADJ
admet-193	291	10	variances	variance	NOUN
admet-193	291	11	in	in	ADP
admet-193	291	12	prediction	prediction	NOUN
admet-193	291	13	studies	study	NOUN
admet-193	291	14	,	,	PUNCT
admet-193	291	15	where	where	SCONJ
admet-193	291	16	many	many	ADJ
admet-193	291	17	literature	literature	NOUN
admet-193	291	18	values	value	NOUN
admet-193	291	19	are	be	AUX
admet-193	291	20	pooled	pool	VERB
admet-193	291	21	into	into	ADP
admet-193	291	22	the	the	DET
admet-193	291	23	same	same	ADJ
admet-193	291	24	training	training	NOUN
admet-193	291	25	set	set	NOUN
admet-193	291	26	.	.	PUNCT
admet-193	292	1	molecular	molecular	ADJ
admet-193	292	2	descriptors	descriptor	NOUN
admet-193	292	3	based	base	VERB
admet-193	292	4	on	on	ADP
admet-193	292	5	2d	2d	NUM
admet-193	292	6	considerations	consideration	NOUN
admet-193	292	7	may	may	AUX
admet-193	292	8	be	be	AUX
admet-193	292	9	difficult	difficult	ADJ
admet-193	292	10	to	to	PART
admet-193	292	11	assign	assign	VERB
admet-193	292	12	to	to	PART
admet-193	292	13	test	test	NOUN
admet-193	292	14	compounds	compound	NOUN
admet-193	292	15	which	which	PRON
admet-193	292	16	may	may	AUX
admet-193	292	17	exhibit	exhibit	VERB
admet-193	292	18	significant	significant	ADJ
admet-193	292	19	polymorphism	polymorphism	NOUN
admet-193	292	20	/	/	SYM
admet-193	292	21	solvatomorphism	solvatomorphism	NOUN
admet-193	292	22	.	.	PUNCT
admet-193	293	1	reproducibility	reproducibility	NOUN
admet-193	293	2	of	of	ADP
admet-193	293	3	experimental	experimental	ADJ
admet-193	293	4	solubility	solubility	NOUN
admet-193	293	5	data	data	NOUN
admet-193	293	6	interlaboratory	interlaboratory	NOUN
admet-193	293	7	reproducibility	reproducibility	NOUN
admet-193	293	8	can	can	AUX
admet-193	293	9	be	be	AUX
admet-193	293	10	assessed	assess	VERB
admet-193	293	11	for	for	ADP
admet-193	293	12	a	a	DET
admet-193	293	13	few	few	ADJ
admet-193	293	14	model	model	NOUN
admet-193	293	15	compounds	compound	NOUN
admet-193	293	16	which	which	PRON
admet-193	293	17	are	be	AUX
admet-193	293	18	repeatedly	repeatedly	ADV
admet-193	293	19	used	use	VERB
admet-193	293	20	in	in	ADP
admet-193	293	21	solubility	solubility	NOUN
admet-193	293	22	studies	study	NOUN
admet-193	293	23	.	.	PUNCT
admet-193	294	1	for	for	ADP
admet-193	294	2	example	example	NOUN
admet-193	294	3	,	,	PUNCT
admet-193	294	4	reported	report	VERB
admet-193	294	5	solubility	solubility	NOUN
admet-193	294	6	of	of	ADP
admet-193	294	7	anthracene	anthracene	NOUN
admet-193	294	8	from	from	ADP
admet-193	294	9	17	17	NUM
admet-193	294	10	different	different	ADJ
admet-193	294	11	laboratories	laboratory	NOUN
admet-193	294	12	indicate	indicate	VERB
admet-193	294	13	standard	standard	ADJ
admet-193	294	14	deviation	deviation	NOUN
admet-193	294	15	,	,	PUNCT
admet-193	294	16	sd	sd	ADP
admet-193	294	17	=	=	SYM
admet-193	295	1	0.17	0.17	NUM
admet-193	295	2	log	log	NOUN
admet-193	295	3	unit	unit	NOUN
admet-193	295	4	(	(	PUNCT
admet-193	295	5	kishi	kishi	PROPN
admet-193	295	6	and	and	CCONJ
admet-193	295	7	hashimoto	hashimoto	NOUN
admet-193	295	8	[	[	X
admet-193	295	9	66	66	NUM
admet-193	295	10	]	]	PUNCT
admet-193	295	11	)	)	PUNCT
admet-193	295	12	.	.	PUNCT
admet-193	296	1	additional	additional	ADJ
admet-193	296	2	examples	example	NOUN
admet-193	296	3	for	for	ADP
admet-193	296	4	phenytoin	phenytoin	NOUN
admet-193	296	5	,	,	PUNCT
admet-193	296	6	sd	sd	ADP
admet-193	296	7	=	=	SYM
admet-193	296	8	0.15	0.15	NUM
admet-193	296	9	(	(	PUNCT
admet-193	296	10	n=16	n=16	NOUN
admet-193	296	11	)	)	PUNCT
admet-193	296	12	,	,	PUNCT
admet-193	296	13	flurbiprofen	flurbiprofen	NOUN
admet-193	296	14	,	,	PUNCT
admet-193	296	15	sd	sd	ADP
admet-193	296	16	=	=	SYM
admet-193	296	17	0.19	0.19	NUM
admet-193	296	18	(	(	PUNCT
admet-193	296	19	n=16	n=16	NOUN
admet-193	296	20	)	)	PUNCT
admet-193	296	21	,	,	PUNCT
admet-193	296	22	and	and	CCONJ
admet-193	296	23	diclofenac	diclofenac	NOUN
admet-193	296	24	,	,	PUNCT
admet-193	296	25	sd	sd	ADP
admet-193	296	26	=	=	SYM
admet-193	296	27	0.20	0.20	NUM
admet-193	296	28	(	(	PUNCT
admet-193	296	29	n=20	n=20	NOUN
admet-193	296	30	)	)	PUNCT
admet-193	296	31	show	show	VERB
admet-193	296	32	similar	similar	ADJ
admet-193	296	33	reproducibility	reproducibility	NOUN
admet-193	296	34	(	(	PUNCT
admet-193	296	35	this	this	DET
admet-193	296	36	work	work	NOUN
admet-193	296	37	)	)	PUNCT
admet-193	296	38	.	.	PUNCT
admet-193	297	1	perhaps	perhaps	ADV
admet-193	297	2	,	,	PUNCT
admet-193	297	3	these	these	PRON
admet-193	297	4	can	can	AUX
admet-193	297	5	be	be	AUX
admet-193	297	6	the	the	DET
admet-193	297	7	expected	expect	VERB
admet-193	297	8	interlaboratory	interlaboratory	NOUN
admet-193	297	9	reproducibility	reproducibility	NOUN
admet-193	297	10	values	value	NOUN
admet-193	297	11	for	for	ADP
admet-193	297	12	such	such	ADJ
admet-193	297	13	relatively	relatively	ADV
admet-193	297	14	simple	simple	ADJ
admet-193	297	15	molecules	molecule	NOUN
admet-193	297	16	.	.	PUNCT
admet-193	298	1	however	however	ADV
admet-193	298	2	,	,	PUNCT
admet-193	298	3	ionizable	ionizable	ADJ
admet-193	298	4	molecules	molecule	NOUN
admet-193	298	5	with	with	ADP
admet-193	298	6	very	very	ADV
admet-193	298	7	low	low	ADJ
admet-193	298	8	solubility	solubility	NOUN
admet-193	298	9	might	might	AUX
admet-193	298	10	be	be	AUX
admet-193	298	11	expected	expect	VERB
admet-193	298	12	to	to	PART
admet-193	298	13	have	have	VERB
admet-193	298	14	poorer	poor	ADJ
admet-193	298	15	reproducibility	reproducibility	NOUN
admet-193	298	16	.	.	PUNCT
admet-193	299	1	particularly	particularly	ADV
admet-193	299	2	poignant	poignant	ADJ
admet-193	299	3	examples	example	NOUN
admet-193	299	4	are	be	AUX
admet-193	299	5	indicated	indicate	VERB
admet-193	299	6	(	(	PUNCT
admet-193	299	7	this	this	DET
admet-193	299	8	work	work	NOUN
admet-193	299	9	)	)	PUNCT
admet-193	299	10	by	by	ADP
admet-193	299	11	indomethacin	indomethacin	NOUN
admet-193	299	12	(	(	PUNCT
admet-193	299	13	which	which	PRON
admet-193	299	14	can	can	AUX
admet-193	299	15	be	be	AUX
admet-193	299	16	unstable	unstable	ADJ
admet-193	299	17	at	at	ADP
admet-193	299	18	elevated	elevated	ADJ
admet-193	299	19	ph	ph	NOUN
admet-193	299	20	)	)	PUNCT
admet-193	299	21	,	,	PUNCT
admet-193	299	22	sd	sd	ADP
admet-193	299	23	=	=	SYM
admet-193	299	24	0.79	0.79	NUM
admet-193	299	25	(	(	PUNCT
admet-193	299	26	n=12	n=12	NOUN
admet-193	299	27	)	)	PUNCT
admet-193	299	28	,	,	PUNCT
admet-193	299	29	and	and	CCONJ
admet-193	299	30	terfenadine	terfenadine	NOUN
admet-193	299	31	(	(	PUNCT
admet-193	299	32	whose	whose	DET
admet-193	299	33	unbuffered	unbuffered	ADJ
admet-193	299	34	sw	sw	PROPN
admet-193	299	35	is	be	AUX
admet-193	299	36	strongly	strongly	ADV
admet-193	299	37	affected	affect	VERB
admet-193	299	38	by	by	ADP
admet-193	299	39	ambient	ambient	ADJ
admet-193	299	40	co2	co2	NOUN
admet-193	299	41	)	)	PUNCT
admet-193	299	42	,	,	PUNCT
admet-193	299	43	sd	sd	ADP
admet-193	299	44	=	=	SYM
admet-193	299	45	1.48	1.48	NUM
admet-193	299	46	(	(	PUNCT
admet-193	299	47	n=12	n=12	NOUN
admet-193	299	48	)	)	PUNCT
admet-193	299	49	.	.	PUNCT
admet-193	300	1	the	the	DET
admet-193	300	2	handbook	handbook	NOUN
admet-193	300	3	of	of	ADP
admet-193	300	4	aqueous	aqueous	ADJ
admet-193	300	5	solubility	solubility	NOUN
admet-193	300	6	data	datum	NOUN
admet-193	300	7	[	[	X
admet-193	300	8	19	19	NUM
admet-193	300	9	]	]	PUNCT
admet-193	300	10	is	be	AUX
admet-193	300	11	a	a	DET
admet-193	300	12	massive	massive	ADJ
admet-193	300	13	source	source	NOUN
admet-193	300	14	of	of	ADP
admet-193	300	15	values	value	NOUN
admet-193	300	16	to	to	PART
admet-193	300	17	estimate	estimate	VERB
admet-193	300	18	interlaboratory	interlaboratory	ADJ
admet-193	300	19	reproducibility	reproducibility	NOUN
admet-193	300	20	,	,	PUNCT
admet-193	300	21	although	although	SCONJ
admet-193	300	22	a	a	DET
admet-193	300	23	systematic	systematic	ADJ
admet-193	300	24	analysis	analysis	NOUN
admet-193	300	25	of	of	ADP
admet-193	300	26	the	the	DET
admet-193	300	27	compiled	compile	VERB
admet-193	300	28	data	datum	NOUN
admet-193	300	29	has	have	AUX
admet-193	300	30	not	not	PART
admet-193	300	31	been	be	AUX
admet-193	300	32	published	publish	VERB
admet-193	300	33	,	,	PUNCT
admet-193	300	34	as	as	ADV
admet-193	300	35	far	far	ADV
admet-193	300	36	as	as	SCONJ
admet-193	300	37	we	we	PRON
admet-193	300	38	are	be	AUX
admet-193	300	39	aware	aware	ADJ
admet-193	300	40	.	.	PUNCT
admet-193	301	1	for	for	ADP
admet-193	301	2	411	411	NUM
admet-193	301	3	compounds	compound	NOUN
admet-193	301	4	with	with	ADP
admet-193	301	5	reported	report	VERB
admet-193	301	6	replicate	replicate	ADJ
admet-193	301	7	measurements	measurement	NOUN
admet-193	301	8	,	,	PUNCT
admet-193	301	9	katritzky	katritzky	PROPN
admet-193	301	10	et	et	PROPN
admet-193	301	11	al	al	PROPN
admet-193	301	12	.	.	PUNCT
admet-193	302	1	[	[	X
admet-193	302	2	67	67	NUM
admet-193	302	3	]	]	PUNCT
admet-193	302	4	found	find	VERB
admet-193	302	5	average	average	ADJ
admet-193	302	6	sd	sd	ADP
admet-193	302	7	=	=	SYM
admet-193	302	8	0.58	0.58	NUM
admet-193	302	9	.	.	PUNCT
admet-193	303	1	comparable	comparable	ADJ
admet-193	303	2	values	value	NOUN
admet-193	303	3	have	have	AUX
admet-193	303	4	been	be	AUX
admet-193	303	5	reported	report	VERB
admet-193	303	6	for	for	ADP
admet-193	303	7	research	research	NOUN
admet-193	303	8	compounds	compound	NOUN
admet-193	303	9	.	.	PUNCT
admet-193	304	1	according	accord	VERB
admet-193	304	2	to	to	ADP
admet-193	304	3	taskinen	taskinen	NOUN
admet-193	304	4	and	and	CCONJ
admet-193	304	5	norinder	norinder	VERB
admet-193	304	6	[	[	X
admet-193	304	7	11	11	NUM
admet-193	304	8	]	]	PUNCT
admet-193	304	9	,	,	PUNCT
admet-193	304	10	an	an	DET
admet-193	304	11	astrazeneca	astrazeneca	NOUN
admet-193	304	12	in	in	ADP
admet-193	304	13	-	-	PUNCT
admet-193	304	14	house	house	NOUN
admet-193	304	15	database	database	NOUN
admet-193	304	16	of	of	ADP
admet-193	304	17	solubility	solubility	NOUN
admet-193	304	18	measurements	measurement	NOUN
admet-193	304	19	of	of	ADP
admet-193	304	20	different	different	ADJ
admet-193	304	21	batches	batch	NOUN
admet-193	304	22	of	of	ADP
admet-193	304	23	the	the	DET
admet-193	304	24	same	same	ADJ
admet-193	304	25	compound	compound	NOUN
admet-193	304	26	typically	typically	ADV
admet-193	304	27	showed	show	VERB
admet-193	304	28	reproducibility	reproducibility	NOUN
admet-193	304	29	of	of	ADP
admet-193	304	30	0.49	0.49	NUM
admet-193	304	31	log	log	NOUN
admet-193	304	32	units	unit	NOUN
admet-193	304	33	.	.	PUNCT
admet-193	305	1	higher	high	ADJ
admet-193	305	2	uncertainties	uncertainty	NOUN
admet-193	305	3	had	have	AUX
admet-193	305	4	been	be	AUX
admet-193	305	5	suggested	suggest	VERB
admet-193	305	6	(	(	PUNCT
admet-193	305	7	jorgensen	jorgensen	NOUN
admet-193	305	8	and	and	CCONJ
admet-193	305	9	duffy	duffy	PROPN
admet-193	306	1	[	[	X
admet-193	306	2	5	5	NUM
admet-193	306	3	]	]	PUNCT
admet-193	306	4	;	;	PUNCT
admet-193	306	5	palmer	palmer	PROPN
admet-193	306	6	and	and	CCONJ
admet-193	306	7	mitchell	mitchell	PROPN
admet-193	307	1	[	[	X
admet-193	307	2	17	17	NUM
admet-193	307	3	]	]	PUNCT
admet-193	307	4	)	)	PUNCT
admet-193	307	5	.	.	PUNCT
admet-193	308	1	however	however	ADV
admet-193	308	2	,	,	PUNCT
admet-193	308	3	there	there	PRON
admet-193	308	4	are	be	VERB
admet-193	308	5	many	many	ADJ
admet-193	308	6	compounds	compound	NOUN
admet-193	308	7	determined	determine	VERB
admet-193	308	8	in	in	ADP
admet-193	308	9	different	different	ADJ
admet-193	308	10	laboratories	laboratory	NOUN
admet-193	308	11	that	that	PRON
admet-193	308	12	indicate	indicate	VERB
admet-193	308	13	reproducibility	reproducibility	NOUN
admet-193	308	14	much	much	ADV
admet-193	308	15	less	less	ADJ
admet-193	308	16	than	than	ADP
admet-193	308	17	the	the	DET
admet-193	308	18	above	above	ADJ
admet-193	308	19	sd	sd	ADP
admet-193	308	20	values	value	NOUN
admet-193	308	21	.	.	PUNCT
admet-193	309	1	for	for	ADP
admet-193	309	2	example	example	NOUN
admet-193	309	3	,	,	PUNCT
admet-193	309	4	barbital	barbital	ADJ
admet-193	309	5	,	,	PUNCT
admet-193	309	6	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-193	309	7	,	,	PUNCT
admet-193	309	8	and	and	CCONJ
admet-193	309	9	lidocaine	lidocaine	NOUN
admet-193	309	10	show	show	NOUN
admet-193	309	11	sd	sd	ADP
admet-193	309	12	=	=	SYM
admet-193	309	13	0.08	0.08	NUM
admet-193	309	14	log	log	NOUN
admet-193	309	15	unit	unit	NOUN
admet-193	309	16	for	for	ADP
admet-193	309	17	n	n	NOUN
admet-193	309	18	=	=	SYM
admet-193	309	19	10	10	NUM
admet-193	309	20	-	-	SYM
admet-193	309	21	14	14	NUM
admet-193	309	22	each	each	PRON
admet-193	309	23	;	;	PUNCT
admet-193	309	24	for	for	ADP
admet-193	309	25	hydrocortisone	hydrocortisone	NOUN
admet-193	309	26	sd	sd	NOUN
admet-193	309	27	=	=	SYM
admet-193	309	28	0.07	0.07	NUM
admet-193	309	29	(	(	PUNCT
admet-193	309	30	n=11	n=11	NOUN
admet-193	309	31	)	)	PUNCT
admet-193	309	32	;	;	PUNCT
admet-193	309	33	for	for	ADP
admet-193	309	34	testosterone	testosterone	NOUN
admet-193	309	35	sd	sd	NOUN
admet-193	309	36	=	=	SYM
admet-193	309	37	0.06	0.06	NUM
admet-193	309	38	(	(	PUNCT
admet-193	309	39	n	n	NOUN
admet-193	309	40	=	=	NUM
admet-193	309	41	10	10	NUM
admet-193	309	42	)	)	PUNCT
admet-193	309	43	,	,	PUNCT
admet-193	309	44	and	and	CCONJ
admet-193	309	45	for	for	ADP
admet-193	309	46	acetanilide	acetanilide	ADJ
admet-193	309	47	,	,	PUNCT
admet-193	309	48	aminopyrine	aminopyrine	NOUN
admet-193	309	49	,	,	PUNCT
admet-193	309	50	threonine	threonine	NOUN
admet-193	309	51	,	,	PUNCT
admet-193	309	52	alanine	alanine	NOUN
admet-193	309	53	,	,	PUNCT
admet-193	309	54	5	5	NUM
admet-193	309	55	-	-	PUNCT
admet-193	309	56	fluorouracil	fluorouracil	NOUN
admet-193	309	57	,	,	PUNCT
admet-193	309	58	budesonide	budesonide	NOUN
admet-193	309	59	,	,	PUNCT
admet-193	309	60	minoxidil	minoxidil	ADJ
admet-193	309	61	,	,	PUNCT
admet-193	309	62	fluconazole	fluconazole	NOUN
admet-193	309	63	,	,	PUNCT
admet-193	309	64	avdeef	avdeef	NOUN
admet-193	309	65	admet	admet	PROPN
admet-193	309	66	&	&	CCONJ
admet-193	309	67	dmpk	dmpk	PROPN
admet-193	309	68	3(2	3(2	NUM
admet-193	309	69	)	)	PUNCT
admet-193	309	70	(	(	PUNCT
admet-193	309	71	2015	2015	NUM
admet-193	309	72	)	)	PUNCT
admet-193	309	73	84	84	NUM
admet-193	309	74	-	-	SYM
admet-193	309	75	109	109	NUM
admet-193	309	76	96	96	NUM
admet-193	309	77	corticosterone	corticosterone	NOUN
admet-193	309	78	,	,	PUNCT
admet-193	309	79	phenobarbital	phenobarbital	ADJ
admet-193	309	80	,	,	PUNCT
admet-193	309	81	lidocaine	lidocaine	NOUN
admet-193	309	82	,	,	PUNCT
admet-193	309	83	hydroflumethiazide	hydroflumethiazide	ADV
admet-193	309	84	,	,	PUNCT
admet-193	309	85	acetaminophen	acetaminophen	NOUN
admet-193	309	86	,	,	PUNCT
admet-193	309	87	serine	serine	NOUN
admet-193	309	88	,	,	PUNCT
admet-193	309	89	glycine	glycine	NOUN
admet-193	309	90	,	,	PUNCT
admet-193	309	91	atenolol	atenolol	PROPN
admet-193	309	92	,	,	PUNCT
admet-193	309	93	sd	sd	ADP
admet-193	309	94	=	=	SYM
admet-193	309	95	0.01	0.01	NUM
admet-193	309	96	–	–	PUNCT
admet-193	309	97	0.05	0.05	NUM
admet-193	309	98	(	(	PUNCT
admet-193	309	99	n=	n=	ADJ
admet-193	309	100	4	4	NUM
admet-193	309	101	-	-	SYM
admet-193	309	102	11	11	NUM
admet-193	309	103	)	)	PUNCT
admet-193	309	104	.	.	PUNCT
admet-193	310	1	in	in	ADP
admet-193	310	2	this	this	DET
admet-193	310	3	review	review	NOUN
admet-193	310	4	of	of	ADP
admet-193	310	5	shake	shake	NOUN
admet-193	310	6	-	-	PUNCT
admet-193	310	7	flask	flask	NOUN
admet-193	310	8	solubility	solubility	NOUN
admet-193	310	9	measurement	measurement	NOUN
admet-193	310	10	,	,	PUNCT
admet-193	310	11	it	it	PRON
admet-193	310	12	was	be	AUX
admet-193	310	13	decided	decide	VERB
admet-193	310	14	to	to	PART
admet-193	310	15	include	include	VERB
admet-193	310	16	data	datum	NOUN
admet-193	310	17	from	from	ADP
admet-193	310	18	two	two	NUM
admet-193	310	19	potentiometric	potentiometric	ADJ
admet-193	310	20	methods	method	NOUN
admet-193	310	21	(	(	PUNCT
admet-193	310	22	dtt	dtt	NOUN
admet-193	310	23	and	and	CCONJ
admet-193	310	24	cheqsol	cheqsol	ADJ
admet-193	310	25	–	–	PUNCT
admet-193	310	26	c.f	c.f	PROPN
admet-193	310	27	.	.	PROPN
admet-193	310	28	,	,	PUNCT
admet-193	310	29	appendix	appendix	NOUN
admet-193	310	30	)	)	PUNCT
admet-193	310	31	.	.	PUNCT
admet-193	311	1	it	it	PRON
admet-193	311	2	was	be	AUX
admet-193	311	3	thus	thus	ADV
admet-193	311	4	of	of	ADP
admet-193	311	5	interest	interest	NOUN
admet-193	311	6	to	to	PART
admet-193	311	7	estimate	estimate	VERB
admet-193	311	8	how	how	SCONJ
admet-193	311	9	concordant	concordant	ADJ
admet-193	311	10	the	the	DET
admet-193	311	11	dtt	dtt	NOUN
admet-193	311	12	and	and	CCONJ
admet-193	311	13	cheqsol	cheqsol	PROPN
admet-193	311	14	data	datum	NOUN
admet-193	311	15	are	be	AUX
admet-193	311	16	with	with	ADP
admet-193	311	17	shake	shake	NOUN
admet-193	311	18	-	-	PUNCT
admet-193	311	19	flask	flask	NOUN
admet-193	311	20	(	(	PUNCT
admet-193	311	21	sf	sf	NOUN
admet-193	311	22	)	)	PUNCT
admet-193	311	23	results	result	NOUN
admet-193	311	24	for	for	ADP
admet-193	311	25	molecules	molecule	NOUN
admet-193	311	26	evaluated	evaluate	VERB
admet-193	311	27	by	by	ADP
admet-193	311	28	the	the	DET
admet-193	311	29	different	different	ADJ
admet-193	311	30	approaches	approach	NOUN
admet-193	311	31	from	from	ADP
admet-193	311	32	different	different	ADJ
admet-193	311	33	laboratories	laboratory	NOUN
admet-193	311	34	.	.	PUNCT
admet-193	312	1	figure	figure	NOUN
admet-193	312	2	3a	3a	PROPN
admet-193	312	3	shows	show	VERB
admet-193	312	4	a	a	DET
admet-193	312	5	correlation	correlation	NOUN
admet-193	312	6	plot	plot	NOUN
admet-193	312	7	of	of	ADP
admet-193	312	8	log	log	NOUN
admet-193	312	9	s0	s0	PROPN
admet-193	312	10	(	(	PUNCT
admet-193	312	11	sf	sf	PROPN
admet-193	312	12	)	)	PUNCT
admet-193	312	13	vs.	vs.	ADP
admet-193	312	14	log	log	NOUN
admet-193	312	15	s0	s0	PROPN
admet-193	312	16	(	(	PUNCT
admet-193	312	17	dtt	dtt	PROPN
admet-193	312	18	)	)	PUNCT
admet-193	312	19	.	.	PUNCT
admet-193	313	1	although	although	SCONJ
admet-193	313	2	some	some	PRON
admet-193	313	3	replicate	replicate	VERB
admet-193	313	4	sf	sf	ADJ
admet-193	313	5	measurements	measurement	NOUN
admet-193	313	6	possess	possess	VERB
admet-193	313	7	large	large	ADJ
admet-193	313	8	variances	variance	NOUN
admet-193	313	9	,	,	PUNCT
admet-193	313	10	the	the	DET
admet-193	313	11	two	two	NUM
admet-193	313	12	sets	set	NOUN
admet-193	313	13	of	of	ADP
admet-193	313	14	log	log	NOUN
admet-193	313	15	s0	s0	PROPN
admet-193	313	16	values	value	NOUN
admet-193	313	17	correlated	correlate	VERB
admet-193	313	18	well	well	ADV
admet-193	313	19	:	:	PUNCT
admet-193	313	20	log	log	VERB
admet-193	313	21	s0	s0	PROPN
admet-193	313	22	sf	sf	PROPN
admet-193	313	23	=	=	PUNCT
admet-193	314	1	-0.02	-0.02	PROPN
admet-193	314	2	+	+	NUM
admet-193	314	3	1.01	1.01	NUM
admet-193	314	4	log	log	NOUN
admet-193	314	5	s0	s0	PROPN
admet-193	314	6	dtt	dtt	PROPN
admet-193	314	7	,	,	PUNCT
admet-193	314	8	r2	r2	PROPN
admet-193	314	9	=	=	NOUN
admet-193	314	10	0.95	0.95	NUM
admet-193	314	11	,	,	PUNCT
admet-193	314	12	s	s	NOUN
admet-193	314	13	=	=	NOUN
admet-193	314	14	0.36	0.36	NUM
admet-193	314	15	,	,	PUNCT
admet-193	314	16	f	f	PROPN
admet-193	314	17	=	=	SYM
admet-193	314	18	1093	1093	NUM
admet-193	314	19	,	,	PUNCT
admet-193	314	20	n	n	PROPN
admet-193	314	21	=	=	SYM
admet-193	314	22	62	62	NUM
admet-193	314	23	.	.	PUNCT
admet-193	315	1	based	base	VERB
admet-193	315	2	on	on	ADP
admet-193	315	3	sf	sf	PROPN
admet-193	315	4	replicates	replicate	NOUN
admet-193	315	5	,	,	PUNCT
admet-193	315	6	the	the	DET
admet-193	315	7	average	average	NOUN
admet-193	315	8	sd	sd	NOUN
admet-193	315	9	=	=	SYM
admet-193	315	10	0.27	0.27	NUM
admet-193	315	11	,	,	PUNCT
admet-193	315	12	which	which	PRON
admet-193	315	13	is	be	AUX
admet-193	315	14	not	not	PART
admet-193	315	15	very	very	ADV
admet-193	315	16	different	different	ADJ
admet-193	315	17	for	for	ADP
admet-193	315	18	the	the	DET
admet-193	315	19	correlation	correlation	NOUN
admet-193	315	20	standard	standard	ADJ
admet-193	315	21	deviation	deviation	NOUN
admet-193	315	22	,	,	PUNCT
admet-193	315	23	s	s	NOUN
admet-193	315	24	=	=	NOUN
admet-193	315	25	0.36	0.36	NUM
admet-193	315	26	.	.	PUNCT
admet-193	316	1	the	the	DET
admet-193	316	2	differences	difference	NOUN
admet-193	316	3	between	between	ADP
admet-193	316	4	the	the	DET
admet-193	316	5	two	two	NUM
admet-193	316	6	log	log	NOUN
admet-193	316	7	s0	s0	NOUN
admet-193	316	8	sets	set	NOUN
admet-193	316	9	were	be	AUX
admet-193	316	10	≤	≤	NUM
admet-193	316	11	0.25	0.25	NUM
admet-193	316	12	for	for	ADP
admet-193	316	13	66	66	NUM
admet-193	316	14	%	%	NOUN
admet-193	316	15	of	of	ADP
admet-193	316	16	the	the	DET
admet-193	316	17	molecules	molecule	NOUN
admet-193	316	18	.	.	PUNCT
admet-193	317	1	a	a	DET
admet-193	317	2	weighted	weight	VERB
admet-193	317	3	linear	linear	PROPN
admet-193	317	4	regression	regression	NOUN
admet-193	317	5	,	,	PUNCT
admet-193	317	6	using	use	VERB
admet-193	317	7	the	the	DET
admet-193	317	8	individual	individual	ADJ
admet-193	317	9	inverse	inverse	NOUN
admet-193	317	10	variances	variance	NOUN
admet-193	317	11	of	of	ADP
admet-193	317	12	the	the	DET
admet-193	317	13	sf	sf	PROPN
admet-193	317	14	data	datum	NOUN
admet-193	317	15	as	as	ADP
admet-193	317	16	weights	weight	NOUN
admet-193	317	17	did	do	AUX
admet-193	317	18	not	not	PART
admet-193	317	19	appreciable	appreciable	ADJ
admet-193	317	20	change	change	VERB
admet-193	317	21	the	the	DET
admet-193	317	22	statistics	statistic	NOUN
admet-193	317	23	of	of	ADP
admet-193	317	24	the	the	DET
admet-193	317	25	sf	sf	PROPN
admet-193	317	26	dtt	dtt	PROPN
admet-193	317	27	comparison	comparison	NOUN
admet-193	317	28	.	.	PUNCT
admet-193	318	1	figure	figure	NOUN
admet-193	318	2	3b	3b	PROPN
admet-193	318	3	shows	show	VERB
admet-193	318	4	a	a	DET
admet-193	318	5	plot	plot	NOUN
admet-193	318	6	comparing	compare	VERB
admet-193	318	7	sf	sf	NOUN
admet-193	318	8	to	to	ADP
admet-193	318	9	cheqsol	cheqsol	ADJ
admet-193	318	10	measurements	measurement	NOUN
admet-193	318	11	,	,	PUNCT
admet-193	318	12	indicating	indicate	VERB
admet-193	318	13	that	that	SCONJ
admet-193	318	14	the	the	DET
admet-193	318	15	two	two	NUM
admet-193	318	16	sets	set	NOUN
admet-193	318	17	appear	appear	VERB
admet-193	318	18	comparable	comparable	ADJ
admet-193	318	19	:	:	PUNCT
admet-193	318	20	log	log	NOUN
admet-193	318	21	s0	s0	PROPN
admet-193	318	22	sf	sf	PROPN
admet-193	318	23	=	=	PUNCT
admet-193	319	1	-0.13	-0.13	X
admet-193	320	1	+	+	NUM
admet-193	320	2	1.00	1.00	NUM
admet-193	320	3	log	log	NOUN
admet-193	320	4	s0	s0	PROPN
admet-193	320	5	cheqsol	cheqsol	NOUN
admet-193	320	6	,	,	PUNCT
admet-193	320	7	r2	r2	PROPN
admet-193	320	8	=	=	PUNCT
admet-193	320	9	0.90	0.90	NUM
admet-193	320	10	,	,	PUNCT
admet-193	320	11	s	s	PART
admet-193	320	12	=	=	NOUN
admet-193	320	13	0.52	0.52	NUM
admet-193	320	14	,	,	PUNCT
admet-193	320	15	f	f	PROPN
admet-193	320	16	=	=	SYM
admet-193	320	17	1094	1094	NUM
admet-193	320	18	,	,	PUNCT
admet-193	320	19	n	n	NOUN
admet-193	320	20	=	=	SYM
admet-193	320	21	125	125	NUM
admet-193	320	22	.	.	PUNCT
admet-193	321	1	there	there	PRON
admet-193	321	2	is	be	VERB
admet-193	321	3	a	a	DET
admet-193	321	4	slight	slight	ADJ
admet-193	321	5	bias	bias	NOUN
admet-193	321	6	:	:	PUNCT
admet-193	321	7	s0	s0	PROPN
admet-193	321	8	cheqsol	cheqsol	NOUN
admet-193	321	9	/s0	/s0	PUNCT
admet-193	322	1	sf	sf	NOUN
admet-193	322	2	=	=	PUNCT
admet-193	322	3	1.35	1.35	NUM
admet-193	322	4	(	(	PUNCT
admet-193	322	5	based	base	VERB
admet-193	322	6	on	on	ADP
admet-193	322	7	the	the	DET
admet-193	322	8	intercept	intercept	NOUN
admet-193	322	9	in	in	ADP
admet-193	322	10	the	the	DET
admet-193	322	11	fit	fit	NOUN
admet-193	322	12	)	)	PUNCT
admet-193	322	13	.	.	PUNCT
admet-193	323	1	the	the	DET
admet-193	323	2	average	average	ADJ
admet-193	323	3	sd	sd	NOUN
admet-193	323	4	=	=	SYM
admet-193	323	5	0.25	0.25	NUM
admet-193	323	6	,	,	PUNCT
admet-193	323	7	based	base	VERB
admet-193	323	8	on	on	ADP
admet-193	323	9	sf	sf	PROPN
admet-193	323	10	replicates	replicate	NOUN
admet-193	323	11	,	,	PUNCT
admet-193	323	12	which	which	PRON
admet-193	323	13	is	be	AUX
admet-193	323	14	notably	notably	ADV
admet-193	323	15	less	less	ADJ
admet-193	323	16	than	than	ADP
admet-193	323	17	the	the	DET
admet-193	323	18	s	s	X
admet-193	323	19	=	=	NOUN
admet-193	323	20	0.52	0.52	NUM
admet-193	323	21	from	from	ADP
admet-193	323	22	the	the	DET
admet-193	323	23	correlation	correlation	NOUN
admet-193	323	24	plot	plot	NOUN
admet-193	323	25	.	.	PUNCT
admet-193	324	1	the	the	DET
admet-193	324	2	differences	difference	NOUN
admet-193	324	3	between	between	ADP
admet-193	324	4	the	the	DET
admet-193	324	5	two	two	NUM
admet-193	324	6	sets	set	NOUN
admet-193	324	7	of	of	ADP
admet-193	324	8	log	log	NOUN
admet-193	324	9	s0	s0	PROPN
admet-193	324	10	values	value	NOUN
admet-193	324	11	were	be	AUX
admet-193	324	12	≤	≤	NUM
admet-193	324	13	0.25	0.25	NUM
admet-193	324	14	for	for	ADP
admet-193	324	15	61	61	NUM
admet-193	324	16	%	%	NOUN
admet-193	324	17	of	of	ADP
admet-193	324	18	the	the	DET
admet-193	324	19	molecules	molecule	NOUN
admet-193	324	20	.	.	PUNCT
admet-193	325	1	using	use	VERB
admet-193	325	2	sf	sf	NOUN
admet-193	325	3	-	-	PUNCT
admet-193	325	4	based	base	VERB
admet-193	325	5	variances	variance	NOUN
admet-193	325	6	in	in	ADP
admet-193	325	7	a	a	DET
admet-193	325	8	weighted	weight	VERB
admet-193	325	9	linear	linear	ADJ
admet-193	325	10	regression	regression	NOUN
admet-193	325	11	analysis	analysis	NOUN
admet-193	325	12	produced	produce	VERB
admet-193	325	13	:	:	PUNCT
admet-193	325	14	log	log	NOUN
admet-193	325	15	s0	s0	PROPN
admet-193	325	16	sf	sf	NOUN
admet-193	325	17	=	=	PUNCT
admet-193	326	1	-0.08	-0.08	PRON
admet-193	326	2	+	+	NOUN
admet-193	326	3	0.99	0.99	NUM
admet-193	326	4	log	log	NOUN
admet-193	326	5	s0	s0	PROPN
admet-193	326	6	cheqsol	cheqsol	NOUN
admet-193	326	7	,	,	PUNCT
admet-193	326	8	with	with	ADP
admet-193	326	9	goodness	goodness	NOUN
admet-193	326	10	-	-	PUNCT
admet-193	326	11	of	of	ADP
admet-193	326	12	-	-	PUNCT
admet-193	326	13	fit	fit	NOUN
admet-193	326	14	=	=	NOUN
admet-193	326	15	2.4	2.4	NUM
admet-193	326	16	.	.	PUNCT
admet-193	327	1	it	it	PRON
admet-193	327	2	appears	appear	VERB
admet-193	327	3	that	that	SCONJ
admet-193	327	4	the	the	DET
admet-193	327	5	bias	bias	NOUN
admet-193	327	6	in	in	ADP
admet-193	327	7	the	the	DET
admet-193	327	8	unweighted	unweighted	ADJ
admet-193	327	9	regression	regression	NOUN
admet-193	327	10	is	be	AUX
admet-193	327	11	influenced	influence	VERB
admet-193	327	12	,	,	PUNCT
admet-193	327	13	in	in	ADP
admet-193	327	14	part	part	NOUN
admet-193	327	15	,	,	PUNCT
admet-193	327	16	by	by	ADP
admet-193	327	17	the	the	DET
admet-193	327	18	high	high	ADJ
admet-193	327	19	variance	variance	NOUN
admet-193	327	20	of	of	ADP
admet-193	327	21	some	some	PRON
admet-193	327	22	of	of	ADP
admet-193	327	23	the	the	DET
admet-193	327	24	sf	sf	PROPN
admet-193	327	25	values	value	NOUN
admet-193	327	26	.	.	PUNCT
admet-193	328	1	to	to	PART
admet-193	328	2	put	put	VERB
admet-193	328	3	the	the	DET
admet-193	328	4	above	above	ADJ
admet-193	328	5	two	two	NUM
admet-193	328	6	comparisons	comparison	NOUN
admet-193	328	7	into	into	ADP
admet-193	328	8	perspective	perspective	NOUN
admet-193	328	9	,	,	PUNCT
admet-193	328	10	we	we	PRON
admet-193	328	11	selected	select	VERB
admet-193	328	12	a	a	DET
admet-193	328	13	one	one	NUM
admet-193	328	14	-	-	PUNCT
admet-193	328	15	source	source	NOUN
admet-193	328	16	set	set	NOUN
admet-193	328	17	of	of	ADP
admet-193	328	18	sf	sf	NUM
admet-193	328	19	distilled	distil	VERB
admet-193	328	20	-	-	PUNCT
admet-193	328	21	water	water	NOUN
admet-193	328	22	sw	sw	NOUN
admet-193	328	23	measurements	measurement	NOUN
admet-193	328	24	(	(	PUNCT
admet-193	328	25	with	with	ADP
admet-193	328	26	phsat	phsat	NOUN
admet-193	328	27	and	and	CCONJ
admet-193	328	28	s0	s0	PROPN
admet-193	328	29	calculated	calculate	VERB
admet-193	328	30	with	with	ADP
admet-193	328	31	pdisol	pdisol	ADJ
admet-193	328	32	-	-	PUNCT
admet-193	328	33	x	x	NOUN
admet-193	328	34	)	)	PUNCT
admet-193	328	35	,	,	PUNCT
admet-193	328	36	performed	perform	VERB
admet-193	328	37	in	in	ADP
admet-193	328	38	the	the	DET
admet-193	328	39	same	same	ADJ
admet-193	328	40	laboratory	laboratory	NOUN
admet-193	328	41	using	use	VERB
admet-193	328	42	the	the	DET
admet-193	328	43	same	same	ADJ
admet-193	328	44	assay	assay	NOUN
admet-193	328	45	protocol	protocol	NOUN
admet-193	328	46	for	for	ADP
admet-193	328	47	122	122	NUM
admet-193	328	48	free	free	ADJ
admet-193	328	49	-	-	PUNCT
admet-193	328	50	acids/-bases	acids/-base	NOUN
admet-193	328	51	(	(	PUNCT
admet-193	328	52	rytting	rytte	VERB
admet-193	328	53	et	et	NOUN
admet-193	328	54	al	al	PROPN
admet-193	328	55	.	.	PUNCT
admet-193	329	1	[	[	X
admet-193	329	2	24	24	NUM
admet-193	329	3	]	]	PUNCT
admet-193	329	4	)	)	PUNCT
admet-193	329	5	.	.	PUNCT
admet-193	330	1	for	for	ADP
admet-193	330	2	117	117	NUM
admet-193	330	3	of	of	ADP
admet-193	330	4	the	the	DET
admet-193	330	5	molecules	molecule	NOUN
admet-193	330	6	,	,	PUNCT
admet-193	330	7	there	there	PRON
admet-193	330	8	were	be	VERB
admet-193	330	9	reported	report	VERB
admet-193	330	10	sf	sf	ADJ
admet-193	330	11	values	value	NOUN
admet-193	330	12	from	from	ADP
admet-193	330	13	other	other	ADJ
admet-193	330	14	laboratories	laboratory	NOUN
admet-193	330	15	.	.	PUNCT
admet-193	331	1	figure	figure	VERB
admet-193	331	2	3c	3c	NUM
admet-193	331	3	shows	show	VERB
admet-193	331	4	the	the	DET
admet-193	331	5	sf	sf	PROPN
admet-193	331	6	-	-	PUNCT
admet-193	331	7	to	to	ADP
admet-193	331	8	-	-	PUNCT
admet-193	331	9	sf	sf	NOUN
admet-193	331	10	correlation	correlation	NOUN
admet-193	331	11	plot	plot	NOUN
admet-193	331	12	.	.	PUNCT
admet-193	332	1	as	as	SCONJ
admet-193	332	2	expected	expect	VERB
admet-193	332	3	,	,	PUNCT
admet-193	332	4	the	the	DET
admet-193	332	5	two	two	NUM
admet-193	332	6	sets	set	NOUN
admet-193	332	7	of	of	ADP
admet-193	332	8	data	datum	NOUN
admet-193	332	9	compared	compare	VERB
admet-193	332	10	reasonably	reasonably	ADV
admet-193	332	11	well	well	ADV
admet-193	332	12	:	:	PUNCT
admet-193	332	13	log	log	VERB
admet-193	332	14	s0	s0	PROPN
admet-193	332	15	sf	sf	PROPN
admet-193	332	16	=	=	PUNCT
admet-193	333	1	-0.02	-0.02	PROPN
admet-193	333	2	+	+	NUM
admet-193	333	3	1.01	1.01	NUM
admet-193	333	4	log	log	NOUN
admet-193	333	5	s0	s0	PROPN
admet-193	333	6	rytting	rytting	NOUN
admet-193	333	7	-	-	PUNCT
admet-193	333	8	sf	sf	PROPN
admet-193	333	9	,	,	PUNCT
admet-193	333	10	r2	r2	PROPN
admet-193	333	11	=	=	PROPN
admet-193	333	12	0.93	0.93	NUM
admet-193	333	13	,	,	PUNCT
admet-193	333	14	s	s	PART
admet-193	333	15	=	=	NOUN
admet-193	333	16	0.39	0.39	NUM
admet-193	333	17	,	,	PUNCT
admet-193	333	18	f	f	PROPN
admet-193	333	19	=	=	SYM
admet-193	333	20	1637	1637	NUM
admet-193	333	21	,	,	PUNCT
admet-193	333	22	n	n	NOUN
admet-193	333	23	=	=	SYM
admet-193	333	24	117	117	NUM
admet-193	333	25	.	.	PUNCT
admet-193	334	1	the	the	DET
admet-193	334	2	average	average	ADJ
admet-193	334	3	sd	sd	NOUN
admet-193	334	4	=	=	SYM
admet-193	334	5	0.17	0.17	NUM
admet-193	334	6	,	,	PUNCT
admet-193	334	7	based	base	VERB
admet-193	334	8	on	on	ADP
admet-193	334	9	non	non	ADJ
admet-193	334	10	-	-	ADJ
admet-193	334	11	rytting	rytte	VERB
admet-193	334	12	sf	sf	NOUN
admet-193	334	13	replicates	replicate	NOUN
admet-193	334	14	.	.	PUNCT
admet-193	335	1	(	(	PUNCT
admet-193	335	2	it	it	PRON
admet-193	335	3	is	be	AUX
admet-193	335	4	noteworthy	noteworthy	ADJ
admet-193	335	5	that	that	SCONJ
admet-193	335	6	–	–	PUNCT
admet-193	335	7	with	with	ADP
admet-193	335	8	the	the	DET
admet-193	335	9	exception	exception	NOUN
admet-193	335	10	of	of	ADP
admet-193	335	11	clofazimine	clofazimine	ADJ
admet-193	335	12	–	–	PUNCT
admet-193	335	13	the	the	DET
admet-193	335	14	rytting	rytte	VERB
admet-193	335	15	set	set	NOUN
admet-193	335	16	of	of	ADP
admet-193	335	17	molecules	molecule	NOUN
admet-193	335	18	were	be	AUX
admet-193	335	19	relatively	relatively	ADV
admet-193	335	20	simple	simple	ADJ
admet-193	335	21	.	.	PUNCT
admet-193	335	22	)	)	PUNCT
admet-193	336	1	the	the	DET
admet-193	336	2	differences	difference	NOUN
admet-193	336	3	between	between	ADP
admet-193	336	4	log	log	NOUN
admet-193	336	5	s0	s0	NOUN
admet-193	336	6	values	value	NOUN
admet-193	336	7	from	from	ADP
admet-193	336	8	the	the	DET
admet-193	336	9	two	two	NUM
admet-193	336	10	sf	sf	PROPN
admet-193	336	11	sources	source	NOUN
admet-193	336	12	were	be	AUX
admet-193	336	13	≤	≤	NUM
admet-193	336	14	0.25	0.25	NUM
admet-193	336	15	log	log	NOUN
admet-193	336	16	unit	unit	NOUN
admet-193	336	17	for	for	ADP
admet-193	336	18	70	70	NUM
admet-193	336	19	%	%	NOUN
admet-193	336	20	of	of	ADP
admet-193	336	21	the	the	DET
admet-193	336	22	molecules	molecule	NOUN
admet-193	336	23	.	.	PUNCT
admet-193	337	1	from	from	ADP
admet-193	337	2	the	the	DET
admet-193	337	3	correlation	correlation	NOUN
admet-193	337	4	plots	plot	NOUN
admet-193	337	5	in	in	ADP
admet-193	337	6	figure	figure	NOUN
admet-193	337	7	3	3	NUM
admet-193	337	8	,	,	PUNCT
admet-193	337	9	one	one	PRON
admet-193	337	10	may	may	AUX
admet-193	337	11	conclude	conclude	VERB
admet-193	337	12	that	that	SCONJ
admet-193	337	13	diverse	diverse	ADJ
admet-193	337	14	sets	set	NOUN
admet-193	337	15	of	of	ADP
admet-193	337	16	molecules	molecule	NOUN
admet-193	337	17	show	show	VERB
admet-193	337	18	average	average	ADJ
admet-193	337	19	reproducibility	reproducibility	NOUN
admet-193	337	20	in	in	ADP
admet-193	337	21	the	the	DET
admet-193	337	22	range	range	NOUN
admet-193	337	23	0.17	0.17	NUM
admet-193	337	24	to	to	PART
admet-193	337	25	0.39	0.39	NUM
admet-193	337	26	log	log	NOUN
admet-193	337	27	unit	unit	NOUN
admet-193	337	28	by	by	ADP
admet-193	337	29	the	the	DET
admet-193	337	30	“	"	PUNCT
admet-193	337	31	gold	gold	ADJ
admet-193	337	32	standard	standard	NOUN
admet-193	337	33	”	"	PUNCT
admet-193	337	34	shake	shake	NOUN
admet-193	337	35	-	-	PUNCT
admet-193	337	36	flask	flask	NOUN
admet-193	337	37	method	method	NOUN
admet-193	337	38	.	.	PUNCT
admet-193	338	1	the	the	DET
admet-193	338	2	highsolubility	highsolubility	NOUN
admet-193	338	3	end	end	NOUN
admet-193	338	4	of	of	ADP
admet-193	338	5	the	the	DET
admet-193	338	6	range	range	NOUN
admet-193	338	7	may	may	AUX
admet-193	338	8	be	be	AUX
admet-193	338	9	better	well	ADV
admet-193	338	10	determined	determine	VERB
admet-193	338	11	,	,	PUNCT
admet-193	338	12	whereas	whereas	SCONJ
admet-193	338	13	the	the	DET
admet-193	338	14	low	low	ADJ
admet-193	338	15	-	-	PUNCT
admet-193	338	16	solubility	solubility	NOUN
admet-193	338	17	end	end	NOUN
admet-193	338	18	may	may	AUX
admet-193	338	19	have	have	VERB
admet-193	338	20	higher	high	ADJ
admet-193	338	21	measurement	measurement	NOUN
admet-193	338	22	errors	error	NOUN
admet-193	338	23	.	.	PUNCT
admet-193	339	1	the	the	DET
admet-193	339	2	expected	expect	VERB
admet-193	339	3	reproducibility	reproducibility	NOUN
admet-193	339	4	of	of	ADP
admet-193	339	5	the	the	DET
admet-193	339	6	dtt	dtt	NOUN
admet-193	339	7	method	method	NOUN
admet-193	339	8	,	,	PUNCT
admet-193	339	9	s	s	PART
admet-193	339	10	=	=	NOUN
admet-193	339	11	0.36	0.36	NUM
admet-193	339	12	,	,	PUNCT
admet-193	339	13	appears	appear	VERB
admet-193	339	14	to	to	PART
admet-193	339	15	match	match	VERB
admet-193	339	16	that	that	PRON
admet-193	339	17	of	of	ADP
admet-193	339	18	the	the	DET
admet-193	339	19	sf	sf	PROPN
admet-193	339	20	method	method	NOUN
admet-193	339	21	,	,	PUNCT
admet-193	339	22	while	while	SCONJ
admet-193	339	23	the	the	DET
admet-193	339	24	cheqsol	cheqsol	ADJ
admet-193	339	25	method	method	NOUN
admet-193	339	26	shows	show	VERB
admet-193	339	27	a	a	DET
admet-193	339	28	slightly	slightly	ADV
admet-193	339	29	higher	high	ADJ
admet-193	339	30	value	value	NOUN
admet-193	339	31	,	,	PUNCT
admet-193	339	32	s	s	PART
admet-193	339	33	=	=	SYM
admet-193	339	34	0.52	0.52	NUM
admet-193	339	35	(	(	PUNCT
admet-193	339	36	similar	similar	ADJ
admet-193	339	37	to	to	ADP
admet-193	339	38	the	the	DET
admet-193	339	39	katritzky	katritzky	PROPN
admet-193	339	40	et	et	PROPN
admet-193	339	41	al	al	PROPN
admet-193	339	42	.	.	PUNCT
admet-193	340	1	[	[	X
admet-193	340	2	67	67	NUM
admet-193	340	3	]	]	SYM
admet-193	340	4	estimate	estimate	NOUN
admet-193	340	5	)	)	PUNCT
admet-193	340	6	.	.	PUNCT
admet-193	341	1	in	in	ADP
admet-193	341	2	the	the	DET
admet-193	341	3	entire	entire	ADJ
admet-193	341	4	4557	4557	NUM
admet-193	341	5	-	-	PUNCT
admet-193	341	6	set	set	NOUN
admet-193	341	7	,	,	PUNCT
admet-193	341	8	there	there	PRON
admet-193	341	9	were	be	VERB
admet-193	341	10	786	786	NUM
admet-193	341	11	replicate	replicate	ADJ
admet-193	341	12	log	log	NOUN
admet-193	341	13	s0	s0	NOUN
admet-193	341	14	values	value	NOUN
admet-193	341	15	from	from	ADP
admet-193	341	16	different	different	ADJ
admet-193	341	17	laboratories	laboratory	NOUN
admet-193	341	18	,	,	PUNCT
admet-193	341	19	where	where	SCONJ
admet-193	341	20	two	two	NUM
admet-193	341	21	or	or	CCONJ
admet-193	341	22	more	more	ADJ
admet-193	341	23	values	value	NOUN
admet-193	341	24	could	could	AUX
admet-193	341	25	be	be	AUX
admet-193	341	26	averaged	average	VERB
admet-193	341	27	.	.	PUNCT
admet-193	342	1	the	the	DET
admet-193	342	2	mean	mean	ADJ
admet-193	342	3	sd	sd	NOUN
admet-193	342	4	of	of	ADP
admet-193	342	5	all	all	DET
admet-193	342	6	the	the	DET
admet-193	342	7	averaged	averaged	ADJ
admet-193	342	8	values	value	NOUN
admet-193	342	9	is	be	AUX
admet-193	342	10	0.19	0.19	NUM
admet-193	342	11	log	log	NOUN
admet-193	342	12	unit	unit	NOUN
admet-193	342	13	.	.	PUNCT
admet-193	343	1	it	it	PRON
admet-193	343	2	is	be	AUX
admet-193	343	3	expected	expect	VERB
admet-193	343	4	that	that	SCONJ
admet-193	343	5	the	the	DET
admet-193	343	6	mean	mean	ADJ
admet-193	343	7	value	value	NOUN
admet-193	343	8	of	of	ADP
admet-193	343	9	0.19	0.19	NUM
admet-193	343	10	could	could	AUX
admet-193	343	11	be	be	AUX
admet-193	343	12	further	far	ADV
admet-193	343	13	reduced	reduce	VERB
admet-193	343	14	,	,	PUNCT
admet-193	343	15	to	to	ADP
admet-193	343	16	near	near	ADP
admet-193	343	17	0.15	0.15	NUM
admet-193	343	18	log	log	NOUN
admet-193	343	19	unit	unit	NOUN
admet-193	343	20	,	,	PUNCT
admet-193	343	21	if	if	SCONJ
admet-193	343	22	corrections	correction	NOUN
admet-193	343	23	were	be	AUX
admet-193	343	24	applied	apply	VERB
admet-193	343	25	to	to	PART
admet-193	343	26	normalize	normalize	VERB
admet-193	343	27	log	log	NOUN
admet-193	343	28	s0	s0	PROPN
admet-193	343	29	values	value	NOUN
admet-193	343	30	to	to	ADP
admet-193	343	31	a	a	DET
admet-193	343	32	common	common	ADJ
admet-193	343	33	temperature	temperature	NOUN
admet-193	343	34	(	(	PUNCT
admet-193	343	35	e.g.	e.g.	ADV
admet-193	343	36	,	,	PUNCT
admet-193	343	37	25	25	NUM
admet-193	343	38	°	°	NOUN
admet-193	343	39	c	c	NOUN
admet-193	343	40	)	)	PUNCT
admet-193	343	41	.	.	PUNCT
admet-193	344	1	summary	summary	NOUN
admet-193	344	2	of	of	ADP
admet-193	344	3	the	the	DET
admet-193	344	4	factors	factor	NOUN
admet-193	344	5	affecting	affect	VERB
admet-193	344	6	reproducibility	reproducibility	NOUN
admet-193	344	7	some	some	PRON
admet-193	344	8	of	of	ADP
admet-193	344	9	the	the	DET
admet-193	344	10	factors	factor	NOUN
admet-193	344	11	affecting	affect	VERB
admet-193	344	12	reproducibility	reproducibility	NOUN
admet-193	344	13	of	of	ADP
admet-193	344	14	equilibrium	equilibrium	NOUN
admet-193	344	15	solubility	solubility	NOUN
admet-193	344	16	measurement	measurement	NOUN
admet-193	344	17	discussed	discuss	VERB
admet-193	344	18	above	above	ADV
admet-193	344	19	may	may	AUX
admet-193	344	20	be	be	AUX
admet-193	344	21	summarized	summarize	VERB
admet-193	344	22	in	in	ADP
admet-193	344	23	the	the	DET
admet-193	344	24	list	list	NOUN
admet-193	344	25	:	:	PUNCT
admet-193	344	26			NOUN
admet-193	344	27	incomplete	incomplete	ADJ
admet-193	344	28	dissolution	dissolution	NOUN
admet-193	344	29	over	over	ADP
admet-193	344	30	the	the	DET
admet-193	344	31	equilibration	equilibration	NOUN
admet-193	344	32	time	time	NOUN
admet-193	344	33	(	(	PUNCT
admet-193	344	34	e.g.	e.g.	ADV
admet-193	344	35	,	,	PUNCT
admet-193	344	36	latent	latent	NOUN
admet-193	344	37	supersatured	supersature	VERB
admet-193	344	38	conditions	condition	NOUN
admet-193	344	39	)	)	PUNCT
admet-193	344	40	admet	admet	PROPN
admet-193	344	41	&	&	CCONJ
admet-193	344	42	dmpk	dmpk	PROPN
admet-193	344	43	3(2	3(2	NUM
admet-193	344	44	)	)	PUNCT
admet-193	344	45	(	(	PUNCT
admet-193	344	46	2015	2015	NUM
admet-193	344	47	)	)	PUNCT
admet-193	344	48	84	84	NUM
admet-193	344	49	-	-	SYM
admet-193	344	50	109	109	NUM
admet-193	344	51	equilibrium	equilibrium	NOUN
admet-193	344	52	solubility	solubility	NOUN
admet-193	344	53	measurements	measurement	NOUN
admet-193	344	54	improvements	improvement	NOUN
admet-193	344	55	doi	doi	NOUN
admet-193	344	56	:	:	PUNCT
admet-193	344	57	10.5599	10.5599	NUM
admet-193	344	58	/	/	SYM
admet-193	344	59	admet.3.2.193	admet.3.2.193	PROPN
admet-193	344	60	97	97	NUM
admet-193	344	61			NOUN
admet-193	344	62	inappropriate	inappropriate	ADJ
admet-193	344	63	phase	phase	NOUN
admet-193	344	64	separation	separation	NOUN
admet-193	344	65	(	(	PUNCT
admet-193	344	66	e.g.	e.g.	ADV
admet-193	344	67	,	,	PUNCT
admet-193	344	68	first	first	ADV
admet-193	344	69	centrifuging	centrifuge	VERB
admet-193	344	70	a	a	DET
admet-193	344	71	saturated	saturate	VERB
admet-193	344	72	solution	solution	NOUN
admet-193	344	73	,	,	PUNCT
admet-193	344	74	then	then	ADV
admet-193	344	75	filtering	filter	VERB
admet-193	344	76	the	the	DET
admet-193	344	77	supernatant	supernatant	NOUN
admet-193	344	78	)	)	PUNCT
admet-193	344	79			NOUN
admet-193	344	80	adsorption	adsorption	NOUN
admet-193	344	81	to	to	ADP
admet-193	344	82	the	the	DET
admet-193	344	83	filter	filter	NOUN
admet-193	344	84	or	or	CCONJ
admet-193	344	85	assay	assay	VERB
admet-193	344	86	vial	vial	ADJ
admet-193	344	87	surfaces	surface	NOUN
admet-193	344	88			NOUN
admet-193	344	89	poor	poor	ADJ
admet-193	344	90	wettability	wettability	NOUN
admet-193	344	91			NOUN
admet-193	344	92	formations	formation	NOUN
admet-193	344	93	of	of	ADP
admet-193	344	94	drug	drug	NOUN
admet-193	344	95	aggregates	aggregate	NOUN
admet-193	344	96	/	/	SYM
admet-193	344	97	oligomers	oligomer	NOUN
admet-193	344	98	(	(	PUNCT
admet-193	344	99	dimers	dimer	NOUN
admet-193	344	100	,	,	PUNCT
admet-193	344	101	trimers	trimer	NOUN
admet-193	344	102	,	,	PUNCT
admet-193	344	103	…	…	PUNCT
admet-193	344	104	)	)	PUNCT
admet-193	344	105	,	,	PUNCT
admet-193	344	106	micelles	micelle	NOUN
admet-193	344	107	,	,	PUNCT
admet-193	344	108	and	and	CCONJ
admet-193	344	109	drug	drug	NOUN
admet-193	344	110	-	-	PUNCT
admet-193	344	111	buffer	buffer	NOUN
admet-193	344	112	complexes	complex	NOUN
admet-193	344	113			NOUN
admet-193	344	114	formation	formation	NOUN
admet-193	344	115	of	of	ADP
admet-193	344	116	ion	ion	NOUN
admet-193	344	117	-	-	PUNCT
admet-193	344	118	pair	pair	NOUN
admet-193	344	119	between	between	ADP
admet-193	344	120	ionic	ionic	ADJ
admet-193	344	121	strength	strength	NOUN
admet-193	344	122	adjustor	adjustor	NOUN
admet-193	344	123	(	(	PUNCT
admet-193	344	124	e.g.	e.g.	ADV
admet-193	344	125	,	,	PUNCT
admet-193	344	126	nacl	nacl	NOUN
admet-193	344	127	,	,	PUNCT
admet-193	344	128	kcl	kcl	PROPN
admet-193	344	129	,	,	PUNCT
admet-193	344	130	etc	etc	X
admet-193	344	131	.	.	X
admet-193	344	132	)	)	PUNCT
admet-193	344	133	and	and	CCONJ
admet-193	344	134	charged	charge	VERB
admet-193	344	135	form	form	NOUN
admet-193	344	136	of	of	ADP
admet-193	344	137	drug	drug	NOUN
admet-193	344	138			NOUN
admet-193	344	139	polymorphs	polymorph	NOUN
admet-193	344	140	,	,	PUNCT
admet-193	344	141	hydrates	hydrate	NOUN
admet-193	344	142	,	,	PUNCT
admet-193	344	143	solvates	solvate	NOUN
admet-193	344	144	,	,	PUNCT
admet-193	344	145	amorphous	amorphous	ADJ
admet-193	344	146	forms	form	NOUN
admet-193	344	147			NOUN
admet-193	344	148	stereoisomers	stereoisomer	NOUN
admet-193	344	149	(	(	PUNCT
admet-193	344	150	dl-	dl-	NUM
admet-193	344	151	,	,	PUNCT
admet-193	344	152	d-	d-	X
admet-193	344	153	,	,	PUNCT
admet-193	344	154	l-	l-	NUM
admet-193	344	155	)	)	PUNCT
admet-193	344	156			PUNCT
admet-193	345	1	cis-/transisomers	cis-/transisomer	NOUN
admet-193	345	2			NOUN
admet-193	345	3	not	not	PART
admet-193	345	4	using	use	VERB
admet-193	345	5	buffers	buffer	NOUN
admet-193	345	6	with	with	ADP
admet-193	345	7	low	low	ADJ
admet-193	345	8	-	-	PUNCT
admet-193	345	9	soluble	soluble	ADJ
admet-193	345	10	ionizable	ionizable	ADJ
admet-193	345	11	drugs	drug	NOUN
admet-193	345	12			NOUN
admet-193	345	13	not	not	PART
admet-193	345	14	taking	take	VERB
admet-193	345	15	into	into	ADP
admet-193	345	16	account	account	NOUN
admet-193	345	17	the	the	DET
admet-193	345	18	effect	effect	NOUN
admet-193	345	19	of	of	ADP
admet-193	345	20	ambient	ambient	ADJ
admet-193	345	21	co2	co2	NOUN
admet-193	345	22	on	on	ADP
admet-193	345	23	the	the	DET
admet-193	345	24	water	water	NOUN
admet-193	345	25	solubility	solubility	NOUN
admet-193	345	26	of	of	ADP
admet-193	345	27	low	low	ADJ
admet-193	345	28	-	-	PUNCT
admet-193	345	29	soluble	soluble	ADJ
admet-193	345	30	bases	basis	NOUN
admet-193	345	31			NOUN
admet-193	345	32	using	use	VERB
admet-193	345	33	unnecessarily	unnecessarily	ADV
admet-193	345	34	high	high	ADJ
admet-193	345	35	buffer	buffer	NOUN
admet-193	345	36	concentrations	concentration	NOUN
admet-193	345	37	,	,	PUNCT
admet-193	345	38	possibly	possibly	ADV
admet-193	345	39	effecting	effect	VERB
admet-193	345	40	drug	drug	NOUN
admet-193	345	41	-	-	PUNCT
admet-193	345	42	buffer	buffer	NOUN
admet-193	345	43	complexation	complexation	NOUN
admet-193	345	44			NOUN
admet-193	345	45	not	not	PART
admet-193	345	46	measuring	measure	VERB
admet-193	345	47	the	the	DET
admet-193	345	48	final	final	ADJ
admet-193	345	49	ph	ph	NOUN
admet-193	345	50	of	of	ADP
admet-193	345	51	the	the	DET
admet-193	345	52	equilibrated	equilibrate	VERB
admet-193	345	53	saturated	saturate	VERB
admet-193	345	54	solution	solution	NOUN
admet-193	345	55	of	of	ADP
admet-193	345	56	ionizable	ionizable	ADJ
admet-193	345	57	drugs	drug	NOUN
admet-193	345	58			NOUN
admet-193	345	59	inadequate	inadequate	ADJ
admet-193	345	60	ph	ph	ADJ
admet-193	345	61	electrode	electrode	NOUN
admet-193	345	62	calibration	calibration	NOUN
admet-193	345	63	procedure	procedure	NOUN
admet-193	345	64	at	at	ADP
admet-193	345	65	low	low	ADJ
admet-193	345	66	and	and	CCONJ
admet-193	345	67	high	high	ADJ
admet-193	345	68	ph	ph	NOUN
admet-193	345	69	and	and	CCONJ
admet-193	345	70	in	in	ADP
admet-193	345	71	salt	salt	NOUN
admet-193	345	72	solubility	solubility	NOUN
admet-193	345	73	studies	study	NOUN
admet-193	345	74			NOUN
admet-193	345	75	effect	effect	NOUN
admet-193	345	76	of	of	ADP
admet-193	345	77	impurities	impurity	NOUN
admet-193	345	78	,	,	PUNCT
admet-193	345	79	especially	especially	ADV
admet-193	345	80	those	those	PRON
admet-193	345	81	which	which	PRON
admet-193	345	82	are	be	AUX
admet-193	345	83	ionizable	ionizable	ADJ
admet-193	345	84			NOUN
admet-193	345	85	“	"	PUNCT
admet-193	345	86	promiscuous	promiscuous	ADJ
admet-193	345	87	inhibitor	inhibitor	NOUN
admet-193	345	88	”	"	PUNCT
admet-193	345	89	particles	particle	NOUN
admet-193	345	90	passing	pass	VERB
admet-193	345	91	through	through	ADP
admet-193	345	92	filter	filter	NOUN
admet-193	345	93			NOUN
admet-193	345	94	compound	compound	NOUN
admet-193	345	95	instability	instability	NOUN
admet-193	345	96	at	at	ADP
admet-193	345	97	the	the	DET
admet-193	345	98	extremes	extreme	NOUN
admet-193	345	99	of	of	ADP
admet-193	345	100	ph	ph	PROPN
admet-193	345	101	or	or	CCONJ
admet-193	345	102	over	over	ADP
admet-193	345	103	long	long	ADJ
admet-193	345	104	saturation	saturation	NOUN
admet-193	345	105	times	time	NOUN
admet-193	345	106			NOUN
admet-193	345	107	not	not	PART
admet-193	345	108	sufficiently	sufficiently	ADV
admet-193	345	109	sensitive	sensitive	ADJ
admet-193	345	110	analytical	analytical	ADJ
admet-193	345	111	methods	method	NOUN
admet-193	345	112	used	use	VERB
admet-193	345	113	to	to	PART
admet-193	345	114	determine	determine	VERB
admet-193	345	115	very	very	ADV
admet-193	345	116	low	low	ADJ
admet-193	345	117	drug	drug	NOUN
admet-193	345	118	concentration	concentration	NOUN
admet-193	345	119	from	from	ADP
admet-193	345	120	the	the	DET
admet-193	345	121	perspective	perspective	NOUN
admet-193	345	122	of	of	ADP
admet-193	345	123	predicting	predict	VERB
admet-193	345	124	solubility	solubility	NOUN
admet-193	345	125	,	,	PUNCT
admet-193	345	126	the	the	DET
admet-193	345	127	impact	impact	NOUN
admet-193	345	128	of	of	ADP
admet-193	345	129	many	many	ADJ
admet-193	345	130	of	of	ADP
admet-193	345	131	the	the	DET
admet-193	345	132	above	above	ADJ
admet-193	345	133	factors	factor	NOUN
admet-193	345	134	can	can	AUX
admet-193	345	135	be	be	AUX
admet-193	345	136	minimized	minimize	VERB
admet-193	345	137	by	by	ADP
admet-193	345	138	employing	employ	VERB
admet-193	345	139	good	good	ADJ
admet-193	345	140	experimental	experimental	ADJ
admet-193	345	141	and	and	CCONJ
admet-193	345	142	data	datum	NOUN
admet-193	345	143	analysis	analysis	NOUN
admet-193	345	144	practices	practice	NOUN
admet-193	345	145	.	.	PUNCT
admet-193	346	1	however	however	ADV
admet-193	346	2	,	,	PUNCT
admet-193	346	3	some	some	PRON
admet-193	346	4	of	of	ADP
admet-193	346	5	the	the	DET
admet-193	346	6	factors	factor	NOUN
admet-193	346	7	leading	lead	VERB
admet-193	346	8	to	to	ADP
admet-193	346	9	variability	variability	NOUN
admet-193	346	10	in	in	ADP
admet-193	346	11	measured	measure	VERB
admet-193	346	12	solubility	solubility	NOUN
admet-193	346	13	,	,	PUNCT
admet-193	346	14	such	such	ADJ
admet-193	346	15	as	as	ADP
admet-193	346	16	the	the	DET
admet-193	346	17	formation	formation	NOUN
admet-193	346	18	of	of	ADP
admet-193	346	19	polymorphs	polymorph	NOUN
admet-193	346	20	,	,	PUNCT
admet-193	346	21	hydrates	hydrate	NOUN
admet-193	346	22	,	,	PUNCT
admet-193	346	23	solvates	solvate	NOUN
admet-193	346	24	,	,	PUNCT
admet-193	346	25	amorphous	amorphous	ADJ
admet-193	346	26	solids	solid	NOUN
admet-193	346	27	,	,	PUNCT
admet-193	346	28	and	and	CCONJ
admet-193	346	29	the	the	DET
admet-193	346	30	impact	impact	NOUN
admet-193	346	31	of	of	ADP
admet-193	346	32	stereoisomers	stereoisomer	NOUN
admet-193	346	33	will	will	AUX
admet-193	346	34	be	be	AUX
admet-193	346	35	harder	hard	ADJ
admet-193	346	36	to	to	PART
admet-193	346	37	deal	deal	VERB
admet-193	346	38	with	with	ADP
admet-193	346	39	.	.	PUNCT
admet-193	347	1	further	far	ADV
admet-193	347	2	in	in	ADP
admet-193	347	3	silico	silico	NOUN
admet-193	347	4	insights	insight	NOUN
admet-193	347	5	will	will	AUX
admet-193	347	6	be	be	AUX
admet-193	347	7	needed	need	VERB
admet-193	347	8	to	to	PART
admet-193	347	9	address	address	VERB
admet-193	347	10	these	these	DET
admet-193	347	11	challenges	challenge	NOUN
admet-193	347	12	.	.	PUNCT
admet-193	348	1	recommended	recommend	VERB
admet-193	348	2	procedures	procedure	NOUN
admet-193	348	3	for	for	ADP
admet-193	348	4	more	more	ADV
admet-193	348	5	accurate	accurate	ADJ
admet-193	348	6	solubility	solubility	NOUN
admet-193	348	7	-	-	PUNCT
admet-193	348	8	ph	ph	ADJ
admet-193	348	9	measurements	measurement	NOUN
admet-193	348	10	solubility	solubility	NOUN
admet-193	348	11	units	unit	NOUN
admet-193	348	12	,	,	PUNCT
admet-193	348	13	tabulation	tabulation	NOUN
admet-193	348	14	of	of	ADP
admet-193	348	15	results	result	NOUN
admet-193	348	16	and	and	CCONJ
admet-193	348	17	the	the	DET
admet-193	348	18	use	use	NOUN
admet-193	348	19	of	of	ADP
admet-193	348	20	logarithmic	logarithmic	ADJ
admet-193	348	21	plots	plot	NOUN
admet-193	348	22	following	follow	VERB
admet-193	348	23	the	the	DET
admet-193	348	24	format	format	NOUN
admet-193	348	25	used	use	VERB
admet-193	348	26	in	in	ADP
admet-193	348	27	the	the	DET
admet-193	348	28	handbook	handbook	NOUN
admet-193	348	29	of	of	ADP
admet-193	348	30	aqueous	aqueous	ADJ
admet-193	348	31	solubility	solubility	NOUN
admet-193	348	32	data	datum	NOUN
admet-193	348	33	(	(	PUNCT
admet-193	348	34	yalkowsky	yalkowsky	PROPN
admet-193	348	35	et	et	PROPN
admet-193	348	36	al	al	PROPN
admet-193	348	37	.	.	PUNCT
admet-193	349	1	[	[	X
admet-193	349	2	19	19	NUM
admet-193	349	3	]	]	NUM
admet-193	349	4	)	)	PUNCT
admet-193	349	5	,	,	PUNCT
admet-193	349	6	it	it	PRON
admet-193	349	7	is	be	AUX
admet-193	349	8	recommended	recommend	VERB
admet-193	349	9	that	that	SCONJ
admet-193	349	10	solubility	solubility	NOUN
admet-193	349	11	be	be	AUX
admet-193	349	12	tabulated	tabulate	VERB
admet-193	349	13	both	both	CCONJ
admet-193	349	14	in	in	ADP
admet-193	349	15	molarity	molarity	NOUN
admet-193	349	16	and	and	CCONJ
admet-193	349	17	in	in	ADP
admet-193	349	18	practical	practical	ADJ
admet-193	349	19	(	(	PUNCT
admet-193	349	20	mg	mg	NOUN
admet-193	349	21	/	/	SYM
admet-193	349	22	ml	ml	NOUN
admet-193	349	23	)	)	PUNCT
admet-193	349	24	units	unit	NOUN
admet-193	349	25	.	.	PUNCT
admet-193	350	1	standard	standard	ADJ
admet-193	350	2	deviations	deviation	NOUN
admet-193	350	3	in	in	ADP
admet-193	350	4	the	the	DET
admet-193	350	5	measured	measured	ADJ
admet-193	350	6	solubility	solubility	NOUN
admet-193	350	7	(	(	PUNCT
admet-193	350	8	based	base	VERB
admet-193	350	9	on	on	ADP
admet-193	350	10	averaging	average	VERB
admet-193	350	11	three	three	NUM
admet-193	350	12	or	or	CCONJ
admet-193	350	13	more	more	ADJ
admet-193	350	14	values	value	NOUN
admet-193	350	15	)	)	PUNCT
admet-193	350	16	should	should	AUX
admet-193	350	17	be	be	AUX
admet-193	350	18	included	include	VERB
admet-193	350	19	in	in	ADP
admet-193	350	20	the	the	DET
admet-193	350	21	table	table	NOUN
admet-193	350	22	of	of	ADP
admet-193	350	23	values	value	NOUN
admet-193	350	24	.	.	PUNCT
admet-193	351	1	additionally	additionally	ADV
admet-193	351	2	,	,	PUNCT
admet-193	351	3	a	a	DET
admet-193	351	4	graphical	graphical	ADJ
admet-193	351	5	display	display	NOUN
admet-193	351	6	of	of	ADP
admet-193	351	7	log	log	PROPN
admet-193	351	8	s	s	PROPN
admet-193	351	9	vs.	vs.	X
admet-193	351	10	ph	ph	NOUN
admet-193	351	11	(	(	PUNCT
admet-193	351	12	but	but	CCONJ
admet-193	351	13	not	not	PART
admet-193	351	14	s	s	PROPN
admet-193	351	15	vs.	vs.	X
admet-193	351	16	ph	ph	NOUN
admet-193	351	17	)	)	PUNCT
admet-193	351	18	would	would	AUX
admet-193	351	19	be	be	AUX
admet-193	351	20	visually	visually	ADV
admet-193	351	21	helpful	helpful	ADJ
admet-193	351	22	.	.	PUNCT
admet-193	352	1	in	in	ADP
admet-193	352	2	the	the	DET
admet-193	352	3	logarithmic	logarithmic	ADJ
admet-193	352	4	forms	form	NOUN
admet-193	352	5	,	,	PUNCT
admet-193	352	6	the	the	DET
admet-193	352	7	plots	plot	NOUN
admet-193	352	8	can	can	AUX
admet-193	352	9	serve	serve	VERB
admet-193	352	10	as	as	ADP
admet-193	352	11	templates	template	NOUN
admet-193	352	12	[	[	X
admet-193	352	13	52,57	52,57	NOUN
admet-193	352	14	]	]	PUNCT
admet-193	352	15	,	,	PUNCT
admet-193	352	16	to	to	PART
admet-193	352	17	recognize	recognize	VERB
admet-193	352	18	the	the	DET
admet-193	352	19	presence	presence	NOUN
admet-193	352	20	of	of	ADP
admet-193	352	21	aggregates	aggregate	NOUN
admet-193	352	22	,	,	PUNCT
admet-193	352	23	incomplete	incomplete	ADJ
admet-193	352	24	equilibration	equilibration	NOUN
admet-193	352	25	,	,	PUNCT
admet-193	352	26	corrections	correction	NOUN
admet-193	352	27	for	for	ADP
admet-193	352	28	the	the	DET
admet-193	352	29	presence	presence	NOUN
admet-193	352	30	of	of	ADP
admet-193	352	31	small	small	ADJ
admet-193	352	32	quantities	quantity	NOUN
admet-193	352	33	of	of	ADP
admet-193	352	34	dmso	dmso	NOUN
admet-193	352	35	,	,	PUNCT
admet-193	352	36	etc	etc	X
admet-193	352	37	.	.	X
admet-193	352	38	solubility	solubility	NOUN
admet-193	352	39	methodology	methodology	NOUN
admet-193	352	40	and	and	CCONJ
admet-193	352	41	the	the	DET
admet-193	352	42	benefits	benefit	NOUN
admet-193	352	43	of	of	ADP
admet-193	352	44	knowing	know	VERB
admet-193	352	45	the	the	DET
admet-193	352	46	accurate	accurate	ADJ
admet-193	352	47	pka	pka	PROPN
admet-193	352	48	the	the	DET
admet-193	352	49	“	"	PUNCT
admet-193	352	50	gold	gold	ADJ
admet-193	352	51	standard	standard	NOUN
admet-193	352	52	”	"	PUNCT
admet-193	352	53	multiple	multiple	ADJ
admet-193	352	54	-	-	PUNCT
admet-193	352	55	ph	ph	ADJ
admet-193	352	56	buffer	buffer	NOUN
admet-193	352	57	shake	shake	NOUN
admet-193	352	58	-	-	PUNCT
admet-193	352	59	flask	flask	NOUN
admet-193	352	60	measurement	measurement	NOUN
admet-193	352	61	is	be	AUX
admet-193	352	62	recommended	recommend	VERB
admet-193	352	63	for	for	ADP
admet-193	352	64	challenging	challenge	VERB
admet-193	352	65	ionizable	ionizable	ADJ
admet-193	352	66	molecules	molecule	NOUN
admet-193	352	67	.	.	PUNCT
admet-193	353	1	other	other	ADJ
admet-193	353	2	methods	method	NOUN
admet-193	353	3	may	may	AUX
admet-193	353	4	also	also	ADV
admet-193	353	5	be	be	AUX
admet-193	353	6	satisfactory	satisfactory	ADJ
admet-193	353	7	,	,	PUNCT
admet-193	353	8	provided	provide	VERB
admet-193	353	9	that	that	SCONJ
admet-193	353	10	the	the	DET
admet-193	353	11	henderson	henderson	PROPN
admet-193	353	12	-	-	PUNCT
admet-193	353	13	hasselbalch	hasselbalch	PROPN
admet-193	353	14	relationship	relationship	NOUN
admet-193	353	15	is	be	AUX
admet-193	353	16	independently	independently	ADV
admet-193	353	17	validated	validate	VERB
admet-193	353	18	.	.	PUNCT
admet-193	354	1	miniaturization	miniaturization	NOUN
admet-193	354	2	can	can	AUX
admet-193	354	3	be	be	AUX
admet-193	354	4	recommended	recommend	VERB
admet-193	354	5	,	,	PUNCT
admet-193	354	6	as	as	ADV
admet-193	354	7	long	long	ADV
admet-193	354	8	as	as	SCONJ
admet-193	354	9	the	the	DET
admet-193	354	10	protocols	protocol	NOUN
admet-193	354	11	are	be	AUX
admet-193	354	12	rigorous	rigorous	ADJ
admet-193	354	13	and	and	CCONJ
admet-193	354	14	well	well	ADV
admet-193	354	15	validated	validate	VERB
admet-193	354	16	.	.	PUNCT
admet-193	355	1	for	for	ADP
admet-193	355	2	ionizable	ionizable	ADJ
admet-193	355	3	molecules	molecule	NOUN
admet-193	355	4	,	,	PUNCT
admet-193	355	5	the	the	DET
admet-193	355	6	measurement	measurement	NOUN
admet-193	355	7	of	of	ADP
admet-193	355	8	sw	sw	PROPN
admet-193	355	9	without	without	ADP
admet-193	355	10	stating	state	VERB
admet-193	355	11	the	the	DET
admet-193	355	12	ph	ph	NOUN
admet-193	355	13	is	be	AUX
admet-193	355	14	not	not	PART
admet-193	355	15	recommended	recommend	VERB
admet-193	355	16	.	.	PUNCT
admet-193	356	1	it	it	PRON
admet-193	356	2	is	be	AUX
admet-193	356	3	far	far	ADV
admet-193	356	4	better	well	ADJ
admet-193	356	5	to	to	PART
admet-193	356	6	measure	measure	VERB
admet-193	356	7	sph	sph	NOUN
admet-193	356	8	values	value	NOUN
admet-193	356	9	in	in	ADP
admet-193	356	10	well	well	ADV
admet-193	356	11	-	-	PUNCT
admet-193	356	12	qualified	qualified	ADJ
admet-193	356	13	buffers	buffer	NOUN
admet-193	356	14	(	(	PUNCT
admet-193	356	15	see	see	VERB
admet-193	356	16	below	below	ADV
admet-193	356	17	)	)	PUNCT
admet-193	356	18	,	,	PUNCT
admet-193	356	19	at	at	ADP
admet-193	356	20	three	three	NUM
admet-193	356	21	or	or	CCONJ
admet-193	356	22	more	more	ADJ
admet-193	356	23	ph	ph	ADJ
admet-193	356	24	values	value	NOUN
admet-193	356	25	,	,	PUNCT
admet-193	356	26	bracketing	bracket	VERB
admet-193	356	27	the	the	DET
admet-193	356	28	pka	pka	PROPN
admet-193	356	29	.	.	PUNCT
admet-193	357	1	avdeef	avdeef	PROPN
admet-193	357	2	admet	admet	PROPN
admet-193	357	3	&	&	CCONJ
admet-193	357	4	dmpk	dmpk	PROPN
admet-193	357	5	3(2	3(2	NUM
admet-193	357	6	)	)	PUNCT
admet-193	357	7	(	(	PUNCT
admet-193	357	8	2015	2015	NUM
admet-193	357	9	)	)	PUNCT
admet-193	357	10	84	84	NUM
admet-193	357	11	-	-	SYM
admet-193	357	12	109	109	NUM
admet-193	357	13	98	98	NUM
admet-193	357	14	ionization	ionization	NOUN
admet-193	357	15	constant	constant	ADJ
admet-193	357	16	the	the	DET
admet-193	357	17	log	log	NOUN
admet-193	357	18	s	s	PART
admet-193	357	19	–	–	PUNCT
admet-193	357	20	ph	ph	ADJ
admet-193	357	21	data	datum	NOUN
admet-193	357	22	should	should	AUX
admet-193	357	23	be	be	AUX
admet-193	357	24	evaluated	evaluate	VERB
admet-193	357	25	to	to	PART
admet-193	357	26	estimate	estimate	VERB
admet-193	357	27	the	the	DET
admet-193	357	28	value	value	NOUN
admet-193	357	29	of	of	ADP
admet-193	357	30	the	the	DET
admet-193	357	31	intrinsic	intrinsic	ADJ
admet-193	357	32	solubility	solubility	NOUN
admet-193	357	33	,	,	PUNCT
admet-193	357	34	s0	s0	PROPN
admet-193	357	35	.	.	PUNCT
admet-193	358	1	to	to	PART
admet-193	358	2	do	do	VERB
admet-193	358	3	this	this	PRON
admet-193	358	4	,	,	PUNCT
admet-193	358	5	the	the	DET
admet-193	358	6	independently	independently	ADV
admet-193	358	7	-	-	PUNCT
admet-193	358	8	determined	determine	VERB
admet-193	358	9	pka	pka	PROPN
admet-193	358	10	is	be	AUX
admet-193	358	11	needed	need	VERB
admet-193	358	12	.	.	PUNCT
admet-193	359	1	it	it	PRON
admet-193	359	2	is	be	AUX
admet-193	359	3	sometimes	sometimes	ADV
admet-193	359	4	very	very	ADV
admet-193	359	5	inaccurate	inaccurate	ADJ
admet-193	359	6	to	to	PART
admet-193	359	7	use	use	VERB
admet-193	359	8	the	the	DET
admet-193	359	9	solubility	solubility	NOUN
admet-193	359	10	-	-	PUNCT
admet-193	359	11	ph	ph	NOUN
admet-193	359	12	data	datum	NOUN
admet-193	359	13	to	to	PART
admet-193	359	14	determine	determine	VERB
admet-193	359	15	the	the	DET
admet-193	359	16	pka	pka	NOUN
admet-193	359	17	,	,	PUNCT
admet-193	359	18	because	because	SCONJ
admet-193	359	19	usually	usually	ADV
admet-193	359	20	the	the	DET
admet-193	359	21	required	required	ADJ
admet-193	359	22	assumption	assumption	NOUN
admet-193	359	23	is	be	AUX
admet-193	359	24	that	that	SCONJ
admet-193	359	25	the	the	DET
admet-193	359	26	henderson	henderson	PROPN
admet-193	359	27	-	-	PUNCT
admet-193	359	28	hasselbalch	hasselbalch	PROPN
admet-193	359	29	equation	equation	NOUN
admet-193	359	30	is	be	AUX
admet-193	359	31	valid	valid	ADJ
admet-193	359	32	,	,	PUNCT
admet-193	359	33	but	but	CCONJ
admet-193	359	34	it	it	PRON
admet-193	359	35	may	may	AUX
admet-193	359	36	not	not	PART
admet-193	359	37	be	be	AUX
admet-193	359	38	so	so	ADV
admet-193	359	39	for	for	ADP
admet-193	359	40	some	some	DET
admet-193	359	41	particular	particular	ADJ
admet-193	359	42	low	low	ADJ
admet-193	359	43	soluble	soluble	ADJ
admet-193	359	44	molecule	molecule	NOUN
admet-193	359	45	,	,	PUNCT
admet-193	359	46	or	or	CCONJ
admet-193	359	47	when	when	SCONJ
admet-193	359	48	high	high	ADJ
admet-193	359	49	concentrations	concentration	NOUN
admet-193	359	50	are	be	AUX
admet-193	359	51	used	use	VERB
admet-193	359	52	to	to	PART
admet-193	359	53	characterize	characterize	VERB
admet-193	359	54	salt	salt	NOUN
admet-193	359	55	solubility	solubility	NOUN
admet-193	359	56	.	.	PUNCT
admet-193	360	1	it	it	PRON
admet-193	360	2	is	be	AUX
admet-193	360	3	recommended	recommend	VERB
admet-193	360	4	that	that	SCONJ
admet-193	360	5	methods	method	NOUN
admet-193	360	6	specifically	specifically	ADV
admet-193	360	7	designed	design	VERB
admet-193	360	8	to	to	PART
admet-193	360	9	determine	determine	VERB
admet-193	360	10	the	the	DET
admet-193	360	11	ionization	ionization	NOUN
admet-193	360	12	constants	constant	NOUN
admet-193	360	13	of	of	ADP
admet-193	360	14	very	very	ADV
admet-193	360	15	poorly	poorly	ADV
admet-193	360	16	soluble	soluble	ADJ
admet-193	360	17	molecules	molecule	NOUN
admet-193	360	18	are	be	AUX
admet-193	360	19	used	use	VERB
admet-193	360	20	(	(	PUNCT
admet-193	360	21	e.g.	e.g.	ADV
admet-193	360	22	,	,	PUNCT
admet-193	360	23	state	state	NOUN
admet-193	360	24	-	-	PUNCT
admet-193	360	25	of	of	ADP
admet-193	360	26	-	-	PUNCT
admet-193	360	27	the	the	DET
admet-193	360	28	-	-	PUNCT
admet-193	360	29	art	art	NOUN
admet-193	360	30	uv	uv	NOUN
admet-193	360	31	spectrophotometry	spectrophotometry	NOUN
admet-193	360	32	,	,	PUNCT
admet-193	360	33	capillary	capillary	ADJ
admet-193	360	34	electrophoresis	electrophoresis	NOUN
admet-193	360	35	,	,	PUNCT
admet-193	360	36	potentiometry	potentiometry	NOUN
admet-193	360	37	)	)	PUNCT
admet-193	360	38	.	.	PUNCT
admet-193	361	1	these	these	DET
admet-193	361	2	methods	method	NOUN
admet-193	361	3	are	be	AUX
admet-193	361	4	widely	widely	ADV
admet-193	361	5	available	available	ADJ
admet-193	361	6	and	and	CCONJ
admet-193	361	7	have	have	AUX
admet-193	361	8	been	be	AUX
admet-193	361	9	fine	fine	ADV
admet-193	361	10	-	-	PUNCT
admet-193	361	11	tuned	tune	VERB
admet-193	361	12	for	for	ADP
admet-193	361	13	the	the	DET
admet-193	361	14	challenge	challenge	NOUN
admet-193	361	15	.	.	PUNCT
admet-193	362	1	commercial	commercial	ADJ
admet-193	362	2	pka	pka	PROPN
admet-193	362	3	instruments	instrument	NOUN
admet-193	362	4	based	base	VERB
admet-193	362	5	on	on	ADP
admet-193	362	6	the	the	DET
admet-193	362	7	above	above	ADJ
admet-193	362	8	three	three	NUM
admet-193	362	9	technologies	technology	NOUN
admet-193	362	10	are	be	AUX
admet-193	362	11	generally	generally	ADV
admet-193	362	12	well	well	ADV
admet-193	362	13	-	-	PUNCT
admet-193	362	14	supported	support	VERB
admet-193	362	15	by	by	ADP
admet-193	362	16	their	their	PRON
admet-193	362	17	manufacturers	manufacturer	NOUN
admet-193	362	18	.	.	PUNCT
admet-193	363	1	temperature	temperature	NOUN
admet-193	363	2	solubility	solubility	NOUN
admet-193	363	3	is	be	AUX
admet-193	363	4	a	a	DET
admet-193	363	5	function	function	NOUN
admet-193	363	6	of	of	ADP
admet-193	363	7	temperature	temperature	NOUN
admet-193	363	8	,	,	PUNCT
admet-193	363	9	so	so	CCONJ
admet-193	363	10	the	the	DET
admet-193	363	11	assay	assay	NOUN
admet-193	363	12	temperature	temperature	NOUN
admet-193	363	13	always	always	ADV
admet-193	363	14	needs	need	VERB
admet-193	363	15	to	to	PART
admet-193	363	16	be	be	AUX
admet-193	363	17	reported	report	VERB
admet-193	363	18	.	.	PUNCT
admet-193	364	1	it	it	PRON
admet-193	364	2	is	be	AUX
admet-193	364	3	clear	clear	ADJ
admet-193	364	4	that	that	SCONJ
admet-193	364	5	“	"	PUNCT
admet-193	364	6	room	room	NOUN
admet-193	364	7	temperature	temperature	NOUN
admet-193	364	8	”	"	PUNCT
admet-193	364	9	can	can	AUX
admet-193	364	10	be	be	AUX
admet-193	364	11	different	different	ADJ
admet-193	364	12	from	from	ADP
admet-193	364	13	laboratory	laboratory	NOUN
admet-193	364	14	to	to	ADP
admet-193	364	15	laboratory	laboratory	NOUN
admet-193	364	16	,	,	PUNCT
admet-193	364	17	and	and	CCONJ
admet-193	364	18	in	in	ADP
admet-193	364	19	some	some	DET
admet-193	364	20	cases	case	NOUN
admet-193	364	21	,	,	PUNCT
admet-193	364	22	seasonally	seasonally	ADV
admet-193	364	23	variable	variable	ADJ
admet-193	364	24	.	.	PUNCT
admet-193	365	1	it	it	PRON
admet-193	365	2	is	be	AUX
admet-193	365	3	advisable	advisable	ADJ
admet-193	365	4	to	to	PART
admet-193	365	5	measure	measure	VERB
admet-193	365	6	and	and	CCONJ
admet-193	365	7	record	record	VERB
admet-193	365	8	the	the	DET
admet-193	365	9	actual	actual	ADJ
admet-193	365	10	temperature	temperature	NOUN
admet-193	365	11	in	in	ADP
admet-193	365	12	the	the	DET
admet-193	365	13	sample	sample	NOUN
admet-193	365	14	vessel	vessel	NOUN
admet-193	365	15	during	during	ADP
admet-193	365	16	the	the	DET
admet-193	365	17	equilibration	equilibration	NOUN
admet-193	365	18	period	period	NOUN
admet-193	365	19	.	.	PUNCT
admet-193	366	1	or	or	CCONJ
admet-193	366	2	better	well	ADV
admet-193	366	3	yet	yet	ADV
admet-193	366	4	,	,	PUNCT
admet-193	366	5	the	the	DET
admet-193	366	6	measurement	measurement	NOUN
admet-193	366	7	is	be	AUX
admet-193	366	8	performed	perform	VERB
admet-193	366	9	in	in	ADP
admet-193	366	10	a	a	DET
admet-193	366	11	thermostated	thermostated	ADJ
admet-193	366	12	vessel	vessel	NOUN
admet-193	366	13	kept	keep	VERB
admet-193	366	14	at	at	ADP
admet-193	366	15	25/37	25/37	NUM
admet-193	366	16	°	°	ADP
admet-193	366	17	c	c	NOUN
admet-193	366	18	.	.	PUNCT
admet-193	367	1	ionic	ionic	ADJ
admet-193	367	2	strength	strength	NOUN
admet-193	367	3	measured	measure	VERB
admet-193	367	4	solubility	solubility	NOUN
admet-193	367	5	can	can	AUX
admet-193	367	6	be	be	AUX
admet-193	367	7	affected	affect	VERB
admet-193	367	8	by	by	ADP
admet-193	367	9	ionic	ionic	ADJ
admet-193	367	10	strength	strength	NOUN
admet-193	367	11	(	(	PUNCT
admet-193	367	12	particularly	particularly	ADV
admet-193	367	13	when	when	SCONJ
admet-193	367	14	salt	salt	NOUN
admet-193	367	15	solubility	solubility	NOUN
admet-193	367	16	is	be	AUX
admet-193	367	17	measured	measure	VERB
admet-193	367	18	)	)	PUNCT
admet-193	367	19	,	,	PUNCT
admet-193	367	20	so	so	CCONJ
admet-193	367	21	the	the	DET
admet-193	367	22	ionic	ionic	ADJ
admet-193	367	23	strength	strength	NOUN
admet-193	367	24	usually	usually	ADV
admet-193	367	25	needs	need	VERB
admet-193	367	26	to	to	PART
admet-193	367	27	be	be	AUX
admet-193	367	28	reported	report	VERB
admet-193	367	29	.	.	PUNCT
admet-193	368	1	not	not	PART
admet-193	368	2	only	only	ADV
admet-193	368	3	do	do	VERB
admet-193	368	4	the	the	DET
admet-193	368	5	ionic	ionic	ADJ
admet-193	368	6	strength	strength	NOUN
admet-193	368	7	adjustor	adjustor	NOUN
admet-193	368	8	(	(	PUNCT
admet-193	368	9	nacl	nacl	NOUN
admet-193	368	10	,	,	PUNCT
admet-193	368	11	kcl	kcl	PROPN
admet-193	368	12	,	,	PUNCT
admet-193	368	13	etc	etc	X
admet-193	368	14	.	.	X
admet-193	368	15	)	)	PUNCT
admet-193	368	16	and	and	CCONJ
admet-193	368	17	buffers	buffer	NOUN
admet-193	368	18	contribute	contribute	VERB
admet-193	368	19	to	to	ADP
admet-193	368	20	the	the	DET
admet-193	368	21	ionic	ionic	ADJ
admet-193	368	22	strength	strength	NOUN
admet-193	368	23	,	,	PUNCT
admet-193	368	24	but	but	CCONJ
admet-193	368	25	so	so	ADV
admet-193	368	26	does	do	VERB
admet-193	368	27	the	the	DET
admet-193	368	28	sample	sample	NOUN
admet-193	368	29	,	,	PUNCT
admet-193	368	30	especially	especially	ADV
admet-193	368	31	when	when	SCONJ
admet-193	368	32	introduced	introduce	VERB
admet-193	368	33	in	in	ADP
admet-193	368	34	salt	salt	NOUN
admet-193	368	35	form	form	NOUN
admet-193	368	36	.	.	PUNCT
admet-193	369	1	equilibration	equilibration	NOUN
admet-193	369	2	time	time	NOUN
admet-193	369	3	and	and	CCONJ
admet-193	369	4	stirring	stirring	ADJ
admet-193	369	5	protocol	protocol	NOUN
admet-193	369	6	finely	finely	ADV
admet-193	369	7	granulated	granulate	VERB
admet-193	369	8	crystals	crystal	NOUN
admet-193	369	9	dissolve	dissolve	VERB
admet-193	369	10	more	more	ADV
admet-193	369	11	quickly	quickly	ADV
admet-193	369	12	than	than	ADP
admet-193	369	13	large	large	ADJ
admet-193	369	14	crystals	crystal	NOUN
admet-193	369	15	,	,	PUNCT
admet-193	369	16	illustrating	illustrate	VERB
admet-193	369	17	the	the	DET
admet-193	369	18	surface	surface	NOUN
admet-193	369	19	area	area	NOUN
admet-193	369	20	effect	effect	NOUN
admet-193	369	21	in	in	ADP
admet-193	369	22	the	the	DET
admet-193	369	23	classical	classical	ADJ
admet-193	369	24	noyce	noyce	PROPN
admet-193	369	25	-	-	PUNCT
admet-193	369	26	whitney	whitney	PROPN
admet-193	369	27	equation	equation	NOUN
admet-193	369	28	(	(	PUNCT
admet-193	369	29	eq	eq	NOUN
admet-193	369	30	.	.	NOUN
admet-193	369	31	5	5	NUM
admet-193	369	32	in	in	ADP
admet-193	369	33	the	the	DET
admet-193	369	34	appendix	appendix	NOUN
admet-193	369	35	)	)	PUNCT
admet-193	369	36	.	.	PUNCT
admet-193	370	1	amorphous	amorphous	ADJ
admet-193	370	2	solids	solid	NOUN
admet-193	370	3	,	,	PUNCT
admet-193	370	4	which	which	PRON
admet-193	370	5	are	be	AUX
admet-193	370	6	generally	generally	ADV
admet-193	370	7	more	more	ADV
admet-193	370	8	soluble	soluble	ADJ
admet-193	370	9	than	than	ADP
admet-193	370	10	their	their	PRON
admet-193	370	11	crystalline	crystalline	NOUN
admet-193	370	12	counterparts	counterpart	NOUN
admet-193	370	13	,	,	PUNCT
admet-193	370	14	dissolve	dissolve	VERB
admet-193	370	15	more	more	ADV
admet-193	370	16	quickly	quickly	ADV
admet-193	370	17	than	than	ADP
admet-193	370	18	crystals	crystal	NOUN
admet-193	370	19	,	,	PUNCT
admet-193	370	20	illustrating	illustrate	VERB
admet-193	370	21	the	the	DET
admet-193	370	22	solubility	solubility	NOUN
admet-193	370	23	effect	effect	NOUN
admet-193	370	24	–	–	PUNCT
admet-193	370	25	the	the	DET
admet-193	370	26	rate	rate	NOUN
admet-193	370	27	of	of	ADP
admet-193	370	28	dissolution	dissolution	NOUN
admet-193	370	29	is	be	AUX
admet-193	370	30	proportional	proportional	ADJ
admet-193	370	31	to	to	ADP
admet-193	370	32	the	the	DET
admet-193	370	33	solubility	solubility	NOUN
admet-193	370	34	(	(	PUNCT
admet-193	370	35	cf	cf	NOUN
admet-193	370	36	.	.	PROPN
admet-193	370	37	,	,	PUNCT
admet-193	370	38	noyce	noyce	PROPN
admet-193	370	39	-	-	PUNCT
admet-193	370	40	whitney	whitney	PROPN
admet-193	370	41	equation	equation	NOUN
admet-193	370	42	,	,	PUNCT
admet-193	370	43	eq	eq	NOUN
admet-193	370	44	.	.	PROPN
admet-193	370	45	5	5	NUM
admet-193	370	46	in	in	ADP
admet-193	370	47	the	the	DET
admet-193	370	48	appendix	appendix	NOUN
admet-193	370	49	)	)	PUNCT
admet-193	370	50	.	.	PUNCT
admet-193	371	1	other	other	ADJ
admet-193	371	2	examples	example	NOUN
admet-193	371	3	of	of	ADP
admet-193	371	4	this	this	PRON
admet-193	371	5	are	be	AUX
admet-193	371	6	:	:	PUNCT
admet-193	371	7	anhydrous	anhydrous	ADJ
admet-193	371	8	crystals	crystal	NOUN
admet-193	371	9	dissolve	dissolve	VERB
admet-193	371	10	more	more	ADV
admet-193	371	11	quickly	quickly	ADV
admet-193	371	12	than	than	ADP
admet-193	371	13	hydrates	hydrate	NOUN
admet-193	371	14	;	;	PUNCT
admet-193	371	15	usually	usually	ADV
admet-193	371	16	pure	pure	ADJ
admet-193	371	17	enantiomers	enantiomer	NOUN
admet-193	371	18	dissolve	dissolve	VERB
admet-193	371	19	more	more	ADV
admet-193	371	20	quickly	quickly	ADV
admet-193	371	21	than	than	ADP
admet-193	371	22	racemic	racemic	ADJ
admet-193	371	23	mixtures	mixture	NOUN
admet-193	371	24	.	.	PUNCT
admet-193	372	1	vigorous	vigorous	ADJ
admet-193	372	2	stirring	stirring	NOUN
admet-193	372	3	during	during	ADP
admet-193	372	4	the	the	DET
admet-193	372	5	equilibration	equilibration	NOUN
admet-193	372	6	period	period	NOUN
admet-193	372	7	can	can	AUX
admet-193	372	8	hasten	hasten	VERB
admet-193	372	9	the	the	DET
admet-193	372	10	rate	rate	NOUN
admet-193	372	11	of	of	ADP
admet-193	372	12	dissolution	dissolution	NOUN
admet-193	372	13	,	,	PUNCT
admet-193	372	14	allowing	allow	VERB
admet-193	372	15	for	for	SCONJ
admet-193	372	16	equilibrium	equilibrium	NOUN
admet-193	372	17	to	to	PART
admet-193	372	18	be	be	AUX
admet-193	372	19	reached	reach	VERB
admet-193	372	20	more	more	ADV
admet-193	372	21	quickly	quickly	ADV
admet-193	372	22	(	(	PUNCT
admet-193	372	23	cf	cf	NOUN
admet-193	372	24	.	.	NOUN
admet-193	372	25	,	,	PUNCT
admet-193	372	26	simple	simple	ADJ
admet-193	372	27	noyce	noyce	PROPN
admet-193	372	28	-	-	PUNCT
admet-193	372	29	whitney	whitney	PROPN
admet-193	372	30	equation	equation	NOUN
admet-193	372	31	)	)	PUNCT
admet-193	372	32	.	.	PUNCT
admet-193	373	1	however	however	ADV
admet-193	373	2	,	,	PUNCT
admet-193	373	3	for	for	ADP
admet-193	373	4	particle	particle	NOUN
admet-193	373	5	less	less	ADJ
admet-193	373	6	than	than	ADP
admet-193	373	7	1	1	NUM
admet-193	373	8	-	-	SYM
admet-193	373	9	5	5	NUM
admet-193	373	10	μm	μm	NOUN
admet-193	373	11	in	in	ADP
admet-193	373	12	diameter	diameter	NOUN
admet-193	373	13	,	,	PUNCT
admet-193	373	14	stirring	stir	VERB
admet-193	373	15	speed	speed	NOUN
admet-193	373	16	has	have	VERB
admet-193	373	17	little	little	ADJ
admet-193	373	18	influence	influence	NOUN
admet-193	373	19	on	on	ADP
admet-193	373	20	the	the	DET
admet-193	373	21	rate	rate	NOUN
admet-193	373	22	of	of	ADP
admet-193	373	23	dissolution	dissolution	NOUN
admet-193	373	24	.	.	PUNCT
admet-193	374	1	towards	towards	ADP
admet-193	374	2	the	the	DET
admet-193	374	3	end	end	NOUN
admet-193	374	4	of	of	ADP
admet-193	374	5	the	the	DET
admet-193	374	6	equilibration	equilibration	NOUN
admet-193	374	7	period	period	NOUN
admet-193	374	8	,	,	PUNCT
admet-193	374	9	stopping	stop	VERB
admet-193	374	10	(	(	PUNCT
admet-193	374	11	or	or	CCONJ
admet-193	374	12	slowing	slow	VERB
admet-193	374	13	)	)	PUNCT
admet-193	374	14	the	the	DET
admet-193	374	15	stirring	stirring	NOUN
admet-193	374	16	and	and	CCONJ
admet-193	374	17	allowing	allow	VERB
admet-193	374	18	the	the	DET
admet-193	374	19	solid	solid	NOUN
admet-193	374	20	to	to	ADP
admet-193	374	21	sediment	sediment	NOUN
admet-193	374	22	probably	probably	ADV
admet-193	374	23	contributes	contribute	VERB
admet-193	374	24	to	to	ADP
admet-193	374	25	formation	formation	NOUN
admet-193	374	26	of	of	ADP
admet-193	374	27	better	well	ADJ
admet-193	374	28	quality	quality	NOUN
admet-193	374	29	crystals	crystal	NOUN
admet-193	374	30	.	.	PUNCT
admet-193	375	1	the	the	DET
admet-193	375	2	80	80	NUM
admet-193	375	3	%	%	NOUN
admet-193	375	4	stirring	stirring	NOUN
admet-193	375	5	–	–	PUNCT
admet-193	375	6	20	20	NUM
admet-193	375	7	%	%	NOUN
admet-193	375	8	sedimentation	sedimentation	NOUN
admet-193	375	9	timing	timing	NOUN
admet-193	375	10	protocol	protocol	NOUN
admet-193	375	11	describe	describe	NOUN
admet-193	375	12	by	by	ADP
admet-193	375	13	baka	baka	PROPN
admet-193	375	14	et	et	PROPN
admet-193	375	15	al	al	PROPN
admet-193	375	16	.	.	PUNCT
admet-193	376	1	[	[	X
admet-193	376	2	68	68	NUM
admet-193	376	3	]	]	X
admet-193	376	4	can	can	AUX
admet-193	376	5	be	be	AUX
admet-193	376	6	recommended	recommend	VERB
admet-193	376	7	.	.	PUNCT
admet-193	377	1	in	in	ADP
admet-193	377	2	regions	region	NOUN
admet-193	377	3	of	of	ADP
admet-193	377	4	ph	ph	NOUN
admet-193	377	5	where	where	SCONJ
admet-193	377	6	the	the	DET
admet-193	377	7	sample	sample	NOUN
admet-193	377	8	molecule	molecule	NOUN
admet-193	377	9	is	be	AUX
admet-193	377	10	largely	largely	ADV
admet-193	377	11	ionized	ionize	VERB
admet-193	377	12	,	,	PUNCT
admet-193	377	13	equilibration	equilibration	NOUN
admet-193	377	14	times	time	NOUN
admet-193	377	15	as	as	ADV
admet-193	377	16	short	short	ADJ
admet-193	377	17	as	as	ADP
admet-193	377	18	1	1	NUM
admet-193	377	19	-	-	SYM
admet-193	377	20	6	6	NUM
admet-193	377	21	hours	hour	NOUN
admet-193	377	22	may	may	AUX
admet-193	377	23	be	be	AUX
admet-193	377	24	adequate	adequate	ADJ
admet-193	377	25	.	.	PUNCT
admet-193	378	1	but	but	CCONJ
admet-193	378	2	for	for	ADP
admet-193	378	3	practically	practically	ADV
admet-193	378	4	insoluble	insoluble	ADJ
admet-193	378	5	molecules	molecule	NOUN
admet-193	378	6	,	,	PUNCT
admet-193	378	7	in	in	ADP
admet-193	378	8	ph	ph	ADJ
admet-193	378	9	regions	region	NOUN
admet-193	378	10	where	where	SCONJ
admet-193	378	11	the	the	DET
admet-193	378	12	molecule	molecule	NOUN
admet-193	378	13	is	be	AUX
admet-193	378	14	largely	largely	ADV
admet-193	378	15	in	in	ADP
admet-193	378	16	its	its	PRON
admet-193	378	17	uncharged	uncharged	ADJ
admet-193	378	18	form	form	NOUN
admet-193	378	19	,	,	PUNCT
admet-193	378	20	equilibration	equilibration	NOUN
admet-193	378	21	times	time	NOUN
admet-193	378	22	of	of	ADP
admet-193	378	23	24	24	NUM
admet-193	378	24	-	-	SYM
admet-193	378	25	72	72	NUM
admet-193	378	26	h	h	NOUN
admet-193	378	27	may	may	AUX
admet-193	378	28	be	be	AUX
admet-193	378	29	required	require	VERB
admet-193	378	30	to	to	PART
admet-193	378	31	reach	reach	VERB
admet-193	378	32	equilibrium	equilibrium	NOUN
admet-193	378	33	.	.	PUNCT
admet-193	379	1	often	often	ADV
admet-193	379	2	,	,	PUNCT
admet-193	379	3	the	the	DET
admet-193	379	4	conversion	conversion	NOUN
admet-193	379	5	from	from	ADP
admet-193	379	6	less	less	ADV
admet-193	379	7	stable	stable	ADJ
admet-193	379	8	amorphous	amorphous	ADJ
admet-193	379	9	or	or	CCONJ
admet-193	379	10	anhydrous	anhydrous	ADJ
admet-193	379	11	solids	solid	NOUN
admet-193	379	12	to	to	ADP
admet-193	379	13	more	more	ADV
admet-193	379	14	stable	stable	ADJ
admet-193	379	15	crystalline	crystalline	NOUN
admet-193	379	16	(	(	PUNCT
admet-193	379	17	often	often	ADV
admet-193	379	18	hydrate	hydrate	ADJ
admet-193	379	19	/	/	SYM
admet-193	379	20	solvate	solvate	NOUN
admet-193	379	21	form	form	NOUN
admet-193	379	22	)	)	PUNCT
admet-193	379	23	takes	take	VERB
admet-193	379	24	12	12	NUM
admet-193	379	25	-	-	SYM
admet-193	379	26	24	24	NUM
admet-193	379	27	h	h	NOUN
admet-193	379	28	,	,	PUNCT
admet-193	379	29	and	and	CCONJ
admet-193	379	30	sometimes	sometimes	ADV
admet-193	379	31	longer	long	ADV
admet-193	379	32	.	.	PUNCT
admet-193	380	1	in	in	ADP
admet-193	380	2	rigorous	rigorous	ADJ
admet-193	380	3	applications	application	NOUN
admet-193	380	4	,	,	PUNCT
admet-193	380	5	the	the	DET
admet-193	380	6	shake	shake	NOUN
admet-193	380	7	-	-	PUNCT
admet-193	380	8	flask	flask	NOUN
admet-193	380	9	method	method	NOUN
admet-193	380	10	usually	usually	ADV
admet-193	380	11	determines	determine	VERB
admet-193	380	12	the	the	DET
admet-193	380	13	equilibrium	equilibrium	NOUN
admet-193	380	14	solubility	solubility	NOUN
admet-193	380	15	of	of	ADP
admet-193	380	16	the	the	DET
admet-193	380	17	most	most	ADV
admet-193	380	18	stable	stable	ADJ
admet-193	380	19	solid	solid	ADJ
admet-193	380	20	state	state	NOUN
admet-193	380	21	form	form	NOUN
admet-193	380	22	of	of	ADP
admet-193	380	23	the	the	DET
admet-193	380	24	compound	compound	NOUN
admet-193	380	25	.	.	PUNCT
admet-193	381	1	equilibration	equilibration	NOUN
admet-193	381	2	times	time	NOUN
admet-193	381	3	as	as	ADV
admet-193	381	4	long	long	ADV
admet-193	381	5	as	as	SCONJ
admet-193	381	6	several	several	ADJ
admet-193	381	7	days	day	NOUN
admet-193	381	8	have	have	AUX
admet-193	381	9	been	be	AUX
admet-193	381	10	used	use	VERB
admet-193	381	11	.	.	PUNCT
admet-193	382	1	admet	admet	PROPN
admet-193	382	2	&	&	CCONJ
admet-193	382	3	dmpk	dmpk	PROPN
admet-193	382	4	3(2	3(2	NUM
admet-193	382	5	)	)	PUNCT
admet-193	382	6	(	(	PUNCT
admet-193	382	7	2015	2015	NUM
admet-193	382	8	)	)	PUNCT
admet-193	382	9	84	84	NUM
admet-193	382	10	-	-	SYM
admet-193	382	11	109	109	NUM
admet-193	382	12	equilibrium	equilibrium	NOUN
admet-193	382	13	solubility	solubility	NOUN
admet-193	382	14	measurements	measurement	NOUN
admet-193	382	15	improvements	improvement	NOUN
admet-193	382	16	doi	doi	NOUN
admet-193	382	17	:	:	PUNCT
admet-193	382	18	10.5599	10.5599	NUM
admet-193	382	19	/	/	SYM
admet-193	382	20	admet.3.2.193	admet.3.2.193	X
admet-193	382	21	99	99	NUM
admet-193	382	22	for	for	ADP
admet-193	382	23	example	example	NOUN
admet-193	382	24	,	,	PUNCT
admet-193	382	25	terfenadine	terfenadine	NOUN
admet-193	382	26	studies	study	NOUN
admet-193	382	27	have	have	AUX
admet-193	382	28	used	use	VERB
admet-193	382	29	3	3	NUM
admet-193	382	30	-	-	SYM
admet-193	382	31	4	4	NUM
admet-193	382	32	d	d	NOUN
admet-193	382	33	equilibration	equilibration	NOUN
admet-193	382	34	times	time	NOUN
admet-193	382	35	.	.	PUNCT
admet-193	383	1	steroids	steroid	NOUN
admet-193	383	2	have	have	AUX
admet-193	383	3	been	be	AUX
admet-193	383	4	allowed	allow	VERB
admet-193	383	5	to	to	PART
admet-193	383	6	incubate	incubate	VERB
admet-193	383	7	for	for	ADP
admet-193	383	8	2	2	NUM
admet-193	383	9	-12	-12	NOUN
admet-193	383	10	d.	d.	NOUN
admet-193	383	11	probably	probably	ADV
admet-193	383	12	24	24	NUM
admet-193	383	13	hours	hour	NOUN
admet-193	383	14	is	be	AUX
admet-193	383	15	a	a	DET
admet-193	383	16	good	good	ADJ
admet-193	383	17	average	average	ADJ
admet-193	383	18	time	time	NOUN
admet-193	383	19	,	,	PUNCT
admet-193	383	20	but	but	CCONJ
admet-193	383	21	it	it	PRON
admet-193	383	22	is	be	AUX
admet-193	383	23	a	a	DET
admet-193	383	24	good	good	ADJ
admet-193	383	25	idea	idea	NOUN
admet-193	383	26	to	to	PART
admet-193	383	27	test	test	VERB
admet-193	383	28	longer	long	ADJ
admet-193	383	29	times	time	NOUN
admet-193	383	30	when	when	SCONJ
admet-193	383	31	measuring	measure	VERB
admet-193	383	32	the	the	DET
admet-193	383	33	equilibrium	equilibrium	NOUN
admet-193	383	34	solubility	solubility	NOUN
admet-193	383	35	of	of	ADP
admet-193	383	36	very	very	ADV
admet-193	383	37	poorly	poorly	ADV
admet-193	383	38	-	-	PUNCT
admet-193	383	39	soluble	soluble	ADJ
admet-193	383	40	drugs	drug	NOUN
admet-193	383	41	:	:	PUNCT
admet-193	383	42	48	48	NUM
admet-193	383	43	h	h	NOUN
admet-193	383	44	,	,	PUNCT
admet-193	383	45	or	or	CCONJ
admet-193	383	46	even	even	ADV
admet-193	383	47	3	3	NUM
admet-193	383	48	7	7	NUM
admet-193	383	49	d.	d.	PROPN
admet-193	383	50	perhaps	perhaps	ADV
admet-193	383	51	special	special	ADJ
admet-193	383	52	cases	case	NOUN
admet-193	383	53	like	like	ADP
admet-193	383	54	amiodarone	amiodarone	NOUN
admet-193	383	55	(	(	PUNCT
admet-193	383	56	30	30	NUM
admet-193	383	57	d	d	NOUN
admet-193	383	58	for	for	ADP
admet-193	383	59	full	full	ADJ
admet-193	383	60	therapeutic	therapeutic	ADJ
admet-193	383	61	effect	effect	NOUN
admet-193	383	62	of	of	ADP
admet-193	383	63	oral	oral	ADJ
admet-193	383	64	dose	dose	NOUN
admet-193	383	65	)	)	PUNCT
admet-193	383	66	may	may	AUX
admet-193	383	67	warrant	warrant	VERB
admet-193	383	68	long	long	ADJ
admet-193	383	69	equilibration	equilibration	NOUN
admet-193	383	70	times	time	NOUN
admet-193	383	71	.	.	PUNCT
admet-193	384	1	ordinarily	ordinarily	ADV
admet-193	384	2	,	,	PUNCT
admet-193	384	3	such	such	ADJ
admet-193	384	4	long	long	ADJ
admet-193	384	5	times	time	NOUN
admet-193	384	6	are	be	AUX
admet-193	384	7	not	not	PART
admet-193	384	8	recommended	recommend	VERB
admet-193	384	9	.	.	PUNCT
admet-193	385	1	shortening	shorten	VERB
admet-193	385	2	the	the	DET
admet-193	385	3	equilibration	equilibration	NOUN
admet-193	385	4	time	time	NOUN
admet-193	385	5	the	the	DET
admet-193	385	6	cheqsol	cheqsol	ADJ
admet-193	385	7	method	method	NOUN
admet-193	385	8	uses	use	VERB
admet-193	385	9	cycles	cycle	NOUN
admet-193	385	10	of	of	ADP
admet-193	385	11	dissolution	dissolution	NOUN
admet-193	385	12	and	and	CCONJ
admet-193	385	13	re	re	NOUN
admet-193	385	14	-	-	NOUN
admet-193	385	15	precipitation	precipitation	NOUN
admet-193	385	16	by	by	ADP
admet-193	385	17	ph	ph	ADJ
admet-193	385	18	adjustment	adjustment	NOUN
admet-193	385	19	to	to	PART
admet-193	385	20	shorten	shorten	VERB
admet-193	385	21	the	the	DET
admet-193	385	22	time	time	NOUN
admet-193	385	23	to	to	PART
admet-193	385	24	reach	reach	VERB
admet-193	385	25	equilibrium	equilibrium	NOUN
admet-193	385	26	.	.	PUNCT
admet-193	386	1	presumably	presumably	ADV
admet-193	386	2	,	,	PUNCT
admet-193	386	3	the	the	DET
admet-193	386	4	solid	solid	ADJ
admet-193	386	5	which	which	PRON
admet-193	386	6	re	re	VERB
admet-193	386	7	-	-	NOUN
admet-193	386	8	precipitates	precipitate	NOUN
admet-193	386	9	in	in	ADP
admet-193	386	10	subsequent	subsequent	ADJ
admet-193	386	11	cycles	cycle	NOUN
admet-193	386	12	is	be	AUX
admet-193	386	13	more	more	ADV
admet-193	386	14	active	active	ADJ
admet-193	386	15	than	than	ADP
admet-193	386	16	the	the	DET
admet-193	386	17	original	original	ADJ
admet-193	386	18	crystalline	crystalline	NOUN
admet-193	386	19	material	material	NOUN
admet-193	386	20	,	,	PUNCT
admet-193	386	21	perhaps	perhaps	ADV
admet-193	386	22	being	be	AUX
admet-193	386	23	of	of	ADP
admet-193	386	24	small	small	ADJ
admet-193	386	25	particle	particle	NOUN
admet-193	386	26	size	size	NOUN
admet-193	386	27	(	(	PUNCT
admet-193	386	28	high	high	ADJ
admet-193	386	29	surface	surface	NOUN
admet-193	386	30	area	area	NOUN
admet-193	386	31	)	)	PUNCT
admet-193	386	32	and	and	CCONJ
admet-193	386	33	possibly	possibly	ADV
admet-193	386	34	amorphous	amorphous	ADJ
admet-193	386	35	.	.	PUNCT
admet-193	387	1	loftsson	loftsson	NOUN
admet-193	387	2	et	et	PROPN
admet-193	387	3	al	al	PROPN
admet-193	387	4	.	.	PUNCT
admet-193	388	1	[	[	X
admet-193	388	2	60	60	NUM
admet-193	388	3	]	]	PUNCT
admet-193	388	4	describes	describe	VERB
admet-193	388	5	using	use	VERB
admet-193	388	6	temperature	temperature	NOUN
admet-193	388	7	spiking	spike	VERB
admet-193	388	8	cycles	cycle	NOUN
admet-193	388	9	and	and	CCONJ
admet-193	388	10	seed	seed	NOUN
admet-193	388	11	crystal	crystal	NOUN
admet-193	388	12	to	to	PART
admet-193	388	13	hasten	hasten	VERB
admet-193	388	14	the	the	DET
admet-193	388	15	equilibration	equilibration	NOUN
admet-193	388	16	period	period	NOUN
admet-193	388	17	.	.	PUNCT
admet-193	389	1	the	the	DET
admet-193	389	2	facilitated	facilitate	VERB
admet-193	389	3	dissolution	dissolution	NOUN
admet-193	389	4	method	method	NOUN
admet-193	389	5	of	of	ADP
admet-193	389	6	higuchi	higuchi	PROPN
admet-193	389	7	,	,	PUNCT
admet-193	389	8	described	describe	VERB
admet-193	389	9	in	in	ADP
admet-193	389	10	the	the	DET
admet-193	389	11	appendix	appendix	NOUN
admet-193	389	12	can	can	AUX
admet-193	389	13	be	be	AUX
admet-193	389	14	used	use	VERB
admet-193	389	15	to	to	PART
admet-193	389	16	speed	speed	VERB
admet-193	389	17	up	up	ADP
admet-193	389	18	the	the	DET
admet-193	389	19	rate	rate	NOUN
admet-193	389	20	of	of	ADP
admet-193	389	21	equilibration	equilibration	NOUN
admet-193	389	22	.	.	PUNCT
admet-193	390	1	the	the	DET
admet-193	390	2	method	method	NOUN
admet-193	390	3	is	be	AUX
admet-193	390	4	fundamentally	fundamentally	ADV
admet-193	390	5	rigorous	rigorous	ADJ
admet-193	390	6	and	and	CCONJ
admet-193	390	7	deserved	deserve	VERB
admet-193	390	8	much	much	ADV
admet-193	390	9	more	more	ADJ
admet-193	390	10	attention	attention	NOUN
admet-193	390	11	than	than	SCONJ
admet-193	390	12	it	it	PRON
admet-193	390	13	has	have	AUX
admet-193	390	14	received	receive	VERB
admet-193	390	15	.	.	PUNCT
admet-193	391	1	a	a	DET
admet-193	391	2	comprehensive	comprehensive	ADJ
admet-193	391	3	validation	validation	NOUN
admet-193	391	4	study	study	NOUN
admet-193	391	5	would	would	AUX
admet-193	391	6	be	be	AUX
admet-193	391	7	welcomed	welcome	VERB
admet-193	391	8	.	.	PUNCT
admet-193	392	1	solution	solution	NOUN
admet-193	392	2	composition	composition	NOUN
admet-193	392	3	it	it	PRON
admet-193	392	4	is	be	AUX
admet-193	392	5	a	a	DET
admet-193	392	6	good	good	ADJ
admet-193	392	7	idea	idea	NOUN
admet-193	392	8	to	to	PART
admet-193	392	9	keep	keep	VERB
admet-193	392	10	the	the	DET
admet-193	392	11	assay	assay	NOUN
admet-193	392	12	solutions	solution	NOUN
admet-193	392	13	simple	simple	ADJ
admet-193	392	14	and	and	CCONJ
admet-193	392	15	to	to	PART
admet-193	392	16	define	define	VERB
admet-193	392	17	all	all	DET
admet-193	392	18	components	component	NOUN
admet-193	392	19	precisely	precisely	ADV
admet-193	392	20	!	!	PUNCT
admet-193	393	1	when	when	SCONJ
admet-193	393	2	studying	study	VERB
admet-193	393	3	salt	salt	NOUN
admet-193	393	4	solubility	solubility	NOUN
admet-193	393	5	,	,	PUNCT
admet-193	393	6	it	it	PRON
admet-193	393	7	is	be	AUX
admet-193	393	8	particularly	particularly	ADV
admet-193	393	9	helpful	helpful	ADJ
admet-193	393	10	(	(	PUNCT
admet-193	393	11	and	and	CCONJ
admet-193	393	12	perhaps	perhaps	ADV
admet-193	393	13	necessary	necessary	ADJ
admet-193	393	14	)	)	PUNCT
admet-193	393	15	to	to	PART
admet-193	393	16	specify	specify	VERB
admet-193	393	17	the	the	DET
admet-193	393	18	actual	actual	ADJ
admet-193	393	19	weight	weight	NOUN
admet-193	393	20	of	of	ADP
admet-193	393	21	sample	sample	NOUN
admet-193	393	22	in	in	ADP
admet-193	393	23	each	each	DET
admet-193	393	24	vial	vial	NOUN
admet-193	393	25	.	.	PUNCT
admet-193	394	1	it	it	PRON
admet-193	394	2	is	be	AUX
admet-193	394	3	unhelpful	unhelpful	ADJ
admet-193	394	4	to	to	PART
admet-193	394	5	see	see	VERB
admet-193	394	6	statements	statement	NOUN
admet-193	394	7	such	such	ADJ
admet-193	394	8	as	as	ADP
admet-193	394	9	“	"	PUNCT
admet-193	394	10	excess	excess	ADJ
admet-193	394	11	solid	solid	NOUN
admet-193	394	12	was	be	AUX
admet-193	394	13	added	add	VERB
admet-193	394	14	.	.	PUNCT
admet-193	394	15	”	"	PUNCT
admet-193	395	1	it	it	PRON
admet-193	395	2	is	be	AUX
admet-193	395	3	not	not	PART
admet-193	395	4	enough	enough	ADJ
admet-193	395	5	to	to	PART
admet-193	395	6	state	state	VERB
admet-193	395	7	that	that	SCONJ
admet-193	395	8	“	"	PUNCT
admet-193	395	9	water	water	NOUN
admet-193	395	10	was	be	AUX
admet-193	395	11	used	use	VERB
admet-193	395	12	”	"	PUNCT
admet-193	395	13	as	as	ADP
admet-193	395	14	the	the	DET
admet-193	395	15	solvent	solvent	NOUN
admet-193	395	16	.	.	PUNCT
admet-193	396	1	was	be	AUX
admet-193	396	2	there	there	PRON
admet-193	396	3	any	any	DET
admet-193	396	4	added	add	VERB
admet-193	396	5	ionic	ionic	ADJ
admet-193	396	6	strength	strength	NOUN
admet-193	396	7	adjustor	adjustor	NOUN
admet-193	396	8	(	(	PUNCT
admet-193	396	9	e.g.	e.g.	ADV
admet-193	396	10	,	,	PUNCT
admet-193	396	11	0.15	0.15	NUM
admet-193	396	12	m	m	NOUN
admet-193	396	13	nacl	nacl	NOUN
admet-193	396	14	,	,	PUNCT
admet-193	396	15	etc	etc	X
admet-193	396	16	.	.	X
admet-193	396	17	)	)	PUNCT
admet-193	396	18	?	?	PUNCT
admet-193	397	1	was	be	AUX
admet-193	397	2	carbon	carbon	NOUN
admet-193	397	3	dioxide	dioxide	NOUN
admet-193	397	4	purged	purge	VERB
admet-193	397	5	out	out	ADP
admet-193	397	6	?	?	PUNCT
admet-193	398	1	low	low	ADJ
admet-193	398	2	soluble	soluble	ADJ
admet-193	398	3	bases	basis	NOUN
admet-193	398	4	such	such	ADJ
admet-193	398	5	as	as	ADP
admet-193	398	6	terfenadine	terfenadine	NOUN
admet-193	398	7	can	can	AUX
admet-193	398	8	indicate	indicate	VERB
admet-193	398	9	solubility	solubility	NOUN
admet-193	398	10	over	over	ADP
admet-193	398	11	several	several	ADJ
admet-193	398	12	magnitudes	magnitude	NOUN
admet-193	398	13	due	due	ADP
admet-193	398	14	to	to	ADP
admet-193	398	15	the	the	DET
admet-193	398	16	effect	effect	NOUN
admet-193	398	17	of	of	ADP
admet-193	398	18	ambient	ambient	ADJ
admet-193	398	19	co2	co2	NOUN
admet-193	398	20	in	in	ADP
admet-193	398	21	unbuffered	unbuffered	ADJ
admet-193	398	22	solutions	solution	NOUN
admet-193	398	23	.	.	PUNCT
admet-193	399	1	ph	ph	PROPN
admet-193	399	2	measurement	measurement	NOUN
admet-193	399	3	using	use	VERB
admet-193	399	4	glass	glass	NOUN
admet-193	399	5	electrodes	electrode	NOUN
admet-193	399	6	it	it	PRON
admet-193	399	7	is	be	AUX
admet-193	399	8	not	not	PART
admet-193	399	9	a	a	DET
admet-193	399	10	good	good	ADJ
admet-193	399	11	practice	practice	NOUN
admet-193	399	12	to	to	PART
admet-193	399	13	assume	assume	VERB
admet-193	399	14	that	that	SCONJ
admet-193	399	15	the	the	DET
admet-193	399	16	assay	assay	NOUN
admet-193	399	17	buffer	buffer	NOUN
admet-193	399	18	ph	ph	NOUN
admet-193	399	19	is	be	AUX
admet-193	399	20	not	not	PART
admet-193	399	21	altered	alter	VERB
admet-193	399	22	by	by	ADP
admet-193	399	23	the	the	DET
admet-193	399	24	addition	addition	NOUN
admet-193	399	25	of	of	ADP
admet-193	399	26	sample	sample	NOUN
admet-193	399	27	.	.	PUNCT
admet-193	400	1	it	it	PRON
admet-193	400	2	is	be	AUX
admet-193	400	3	highly	highly	ADV
admet-193	400	4	recommended	recommend	VERB
admet-193	400	5	that	that	SCONJ
admet-193	400	6	the	the	DET
admet-193	400	7	final	final	ADJ
admet-193	400	8	ph	ph	NOUN
admet-193	400	9	of	of	ADP
admet-193	400	10	the	the	DET
admet-193	400	11	saturated	saturate	VERB
admet-193	400	12	solution	solution	NOUN
admet-193	400	13	be	be	AUX
admet-193	400	14	carefully	carefully	ADV
admet-193	400	15	measured	measure	VERB
admet-193	400	16	,	,	PUNCT
admet-193	400	17	using	use	VERB
admet-193	400	18	a	a	DET
admet-193	400	19	properly	properly	ADV
admet-193	400	20	standardized	standardize	VERB
admet-193	400	21	electrodes	electrode	NOUN
admet-193	400	22	.	.	PUNCT
admet-193	401	1	particular	particular	ADJ
admet-193	401	2	attention	attention	NOUN
admet-193	401	3	should	should	AUX
admet-193	401	4	be	be	AUX
admet-193	401	5	given	give	VERB
admet-193	401	6	to	to	ADP
admet-193	401	7	the	the	DET
admet-193	401	8	ph	ph	ADJ
admet-193	401	9	electrode	electrode	NOUN
admet-193	401	10	calibration	calibration	NOUN
admet-193	401	11	,	,	PUNCT
admet-193	401	12	especially	especially	ADV
admet-193	401	13	when	when	SCONJ
admet-193	401	14	extreme	extreme	ADJ
admet-193	401	15	ph	ph	NOUN
admet-193	401	16	is	be	AUX
admet-193	401	17	measured	measure	VERB
admet-193	401	18	(	(	PUNCT
admet-193	401	19	ph	ph	X
admet-193	401	20	<	<	X
admet-193	401	21	1	1	NUM
admet-193	401	22	or	or	CCONJ
admet-193	401	23	ph	ph	ADJ
admet-193	401	24	>	>	X
admet-193	401	25	12	12	NUM
admet-193	401	26	)	)	PUNCT
admet-193	401	27	or	or	CCONJ
admet-193	401	28	when	when	SCONJ
admet-193	401	29	the	the	DET
admet-193	401	30	ionic	ionic	ADJ
admet-193	401	31	strength	strength	NOUN
admet-193	401	32	reaches	reach	VERB
admet-193	401	33	high	high	ADJ
admet-193	401	34	values	value	NOUN
admet-193	401	35	,	,	PUNCT
admet-193	401	36	as	as	ADP
admet-193	401	37	in	in	ADP
admet-193	401	38	the	the	DET
admet-193	401	39	case	case	NOUN
admet-193	401	40	of	of	ADP
admet-193	401	41	salt	salt	NOUN
admet-193	401	42	solubility	solubility	NOUN
admet-193	401	43	measurement	measurement	NOUN
admet-193	401	44	.	.	PUNCT
admet-193	402	1	it	it	PRON
admet-193	402	2	is	be	AUX
admet-193	402	3	recommended	recommend	VERB
admet-193	402	4	that	that	SCONJ
admet-193	402	5	research	research	NOUN
admet-193	402	6	-	-	PUNCT
admet-193	402	7	grade	grade	NOUN
admet-193	402	8	combination	combination	NOUN
admet-193	402	9	ph	ph	NOUN
admet-193	402	10	electrodes	electrode	NOUN
admet-193	402	11	be	be	AUX
admet-193	402	12	used	use	VERB
admet-193	402	13	,	,	PUNCT
admet-193	402	14	with	with	ADP
admet-193	402	15	adequately	adequately	ADV
admet-193	402	16	described	describe	VERB
admet-193	402	17	calibration	calibration	NOUN
admet-193	402	18	procedure	procedure	NOUN
admet-193	402	19	.	.	PUNCT
admet-193	403	1	ideally	ideally	ADV
admet-193	403	2	,	,	PUNCT
admet-193	403	3	the	the	DET
admet-193	403	4	four	four	NUM
admet-193	403	5	-	-	PUNCT
admet-193	403	6	parameter	parameter	NOUN
admet-193	403	7	electrode	electrode	NOUN
admet-193	403	8	calibration	calibration	NOUN
admet-193	403	9	is	be	AUX
admet-193	403	10	recommended	recommend	VERB
admet-193	403	11	[	[	PUNCT
admet-193	403	12	55	55	NUM
admet-193	403	13	]	]	PUNCT
admet-193	403	14	.	.	PUNCT
admet-193	404	1	those	those	PRON
admet-193	404	2	using	use	VERB
admet-193	404	3	the	the	DET
admet-193	404	4	sirius	sirius	PROPN
admet-193	404	5	titrators	titrator	NOUN
admet-193	404	6	will	will	AUX
admet-193	404	7	recognize	recognize	VERB
admet-193	404	8	the	the	DET
admet-193	404	9	procedure	procedure	NOUN
admet-193	404	10	as	as	ADP
admet-193	404	11	“	"	PUNCT
admet-193	404	12	four	four	NUM
admet-193	404	13	-	-	PUNCT
admet-193	404	14	plus	plus	NOUN
admet-193	404	15	”	"	PUNCT
admet-193	404	16	method	method	NOUN
admet-193	404	17	,	,	PUNCT
admet-193	404	18	and	and	CCONJ
admet-193	404	19	those	those	PRON
admet-193	404	20	using	use	VERB
admet-193	404	21	the	the	DET
admet-193	404	22	pion	pion	NOUN
admet-193	404	23	titrators	titrator	NOUN
admet-193	404	24	will	will	AUX
admet-193	404	25	recognize	recognize	VERB
admet-193	404	26	it	it	PRON
admet-193	404	27	as	as	ADP
admet-193	404	28	the	the	DET
admet-193	404	29	“	"	PUNCT
admet-193	404	30	abc	abc	PROPN
admet-193	404	31	”	"	PUNCT
admet-193	404	32	method	method	NOUN
admet-193	404	33	.	.	PUNCT
admet-193	405	1	simpler	simple	ADJ
admet-193	405	2	procedures	procedure	NOUN
admet-193	405	3	may	may	AUX
admet-193	405	4	be	be	AUX
admet-193	405	5	satisfactory	satisfactory	ADJ
admet-193	405	6	,	,	PUNCT
admet-193	405	7	as	as	ADV
admet-193	405	8	long	long	ADV
admet-193	405	9	as	as	SCONJ
admet-193	405	10	they	they	PRON
admet-193	405	11	are	be	AUX
admet-193	405	12	described	describe	VERB
admet-193	405	13	precisely	precisely	ADV
admet-193	405	14	.	.	PUNCT
admet-193	406	1	the	the	DET
admet-193	406	2	reported	report	VERB
admet-193	406	3	ph	ph	NOUN
admet-193	406	4	should	should	AUX
admet-193	406	5	be	be	AUX
admet-193	406	6	evidently	evidently	ADV
admet-193	406	7	either	either	CCONJ
admet-193	406	8	on	on	ADP
admet-193	406	9	the	the	DET
admet-193	406	10	“	"	PUNCT
admet-193	406	11	operational	operational	ADJ
admet-193	406	12	”	"	PUNCT
admet-193	406	13	or	or	CCONJ
admet-193	406	14	the	the	DET
admet-193	406	15	“	"	PUNCT
admet-193	406	16	concentration	concentration	NOUN
admet-193	406	17	”	"	PUNCT
admet-193	406	18	scale	scale	NOUN
admet-193	406	19	;	;	PUNCT
admet-193	406	20	the	the	DET
admet-193	406	21	“	"	PUNCT
admet-193	406	22	mixed	mixed	ADJ
admet-193	406	23	”	"	PUNCT
admet-193	406	24	scale	scale	NOUN
admet-193	406	25	is	be	AUX
admet-193	406	26	not	not	PART
admet-193	406	27	recommended	recommend	VERB
admet-193	406	28	[	[	PUNCT
admet-193	406	29	52	52	NUM
admet-193	406	30	]	]	PUNCT
admet-193	406	31	.	.	PUNCT
admet-193	407	1	a	a	DET
admet-193	407	2	strong	strong	ADJ
admet-193	407	3	case	case	NOUN
admet-193	407	4	can	can	AUX
admet-193	407	5	be	be	AUX
admet-193	407	6	made	make	VERB
admet-193	407	7	that	that	DET
admet-193	407	8	general	general	ADJ
admet-193	407	9	solubility	solubility	NOUN
admet-193	407	10	equilibrium	equilibrium	NOUN
admet-193	407	11	quotients	quotient	NOUN
admet-193	407	12	are	be	AUX
admet-193	407	13	best	well	ADV
admet-193	407	14	formulated	formulate	VERB
admet-193	407	15	in	in	ADP
admet-193	407	16	the	the	DET
admet-193	407	17	concentration	concentration	NOUN
admet-193	407	18	scale	scale	NOUN
admet-193	407	19	(	(	PUNCT
admet-193	407	20	rather	rather	ADV
admet-193	407	21	than	than	ADP
admet-193	407	22	activity	activity	NOUN
admet-193	407	23	)	)	PUNCT
admet-193	407	24	,	,	PUNCT
admet-193	407	25	with	with	SCONJ
admet-193	407	26	ph	ph	ADJ
admet-193	407	27	electrodes	electrode	NOUN
admet-193	407	28	standardized	standardize	VERB
admet-193	407	29	in	in	ADP
admet-193	407	30	a	a	DET
admet-193	407	31	constant	constant	ADJ
admet-193	407	32	ionic	ionic	ADJ
admet-193	407	33	medium	medium	NOUN
admet-193	407	34	,	,	PUNCT
admet-193	407	35	e.g.	e.g.	ADV
admet-193	407	36	,	,	PUNCT
admet-193	407	37	0.15	0.15	NUM
admet-193	407	38	m	m	NOUN
admet-193	407	39	nacl	nacl	NOUN
admet-193	408	1	[	[	X
admet-193	408	2	52	52	NUM
admet-193	408	3	]	]	PUNCT
admet-193	408	4	.	.	PUNCT
admet-193	409	1	this	this	PRON
admet-193	409	2	may	may	AUX
admet-193	409	3	be	be	AUX
admet-193	409	4	especially	especially	ADV
admet-193	409	5	important	important	ADJ
admet-193	409	6	when	when	SCONJ
admet-193	409	7	salt	salt	NOUN
admet-193	409	8	solubility	solubility	NOUN
admet-193	409	9	measurements	measurement	NOUN
admet-193	409	10	are	be	AUX
admet-193	409	11	performed	perform	VERB
admet-193	409	12	.	.	PUNCT
admet-193	410	1	avdeef	avdeef	PROPN
admet-193	410	2	admet	admet	PROPN
admet-193	410	3	&	&	CCONJ
admet-193	410	4	dmpk	dmpk	PROPN
admet-193	410	5	3(2	3(2	NUM
admet-193	410	6	)	)	PUNCT
admet-193	410	7	(	(	PUNCT
admet-193	410	8	2015	2015	NUM
admet-193	410	9	)	)	PUNCT
admet-193	410	10	84	84	NUM
admet-193	410	11	-	-	SYM
admet-193	410	12	109	109	NUM
admet-193	410	13	100	100	NUM
admet-193	410	14	how	how	SCONJ
admet-193	410	15	was	be	AUX
admet-193	410	16	ph	ph	ADJ
admet-193	410	17	adjusted	adjust	VERB
admet-193	410	18	(	(	PUNCT
admet-193	410	19	e.g.	e.g.	ADV
admet-193	410	20	,	,	PUNCT
admet-193	410	21	0.1	0.1	NUM
admet-193	410	22	m	m	NOUN
admet-193	410	23	hcl	hcl	PROPN
admet-193	410	24	,	,	PUNCT
admet-193	410	25	1	1	NUM
admet-193	410	26	m	m	NOUN
admet-193	410	27	naoh	naoh	NOUN
admet-193	410	28	)	)	PUNCT
admet-193	410	29	?	?	PUNCT
admet-193	411	1	statements	statement	NOUN
admet-193	411	2	like	like	ADP
admet-193	411	3	:	:	PUNCT
admet-193	411	4	“	"	PUNCT
admet-193	411	5	concentrated	concentrated	ADJ
admet-193	411	6	h3po4	h3po4	NOUN
admet-193	411	7	was	be	AUX
admet-193	411	8	added	add	VERB
admet-193	411	9	drop	drop	NOUN
admet-193	411	10	-	-	ADJ
admet-193	411	11	wise	wise	ADJ
admet-193	411	12	to	to	PART
admet-193	411	13	adjust	adjust	VERB
admet-193	411	14	the	the	DET
admet-193	411	15	ph	ph	NOUN
admet-193	411	16	”	"	PUNCT
admet-193	411	17	are	be	AUX
admet-193	411	18	not	not	PART
admet-193	411	19	clear	clear	ADJ
admet-193	411	20	enough	enough	ADV
admet-193	411	21	.	.	PUNCT
admet-193	412	1	it	it	PRON
admet-193	412	2	is	be	AUX
admet-193	412	3	far	far	ADV
admet-193	412	4	better	well	ADJ
admet-193	412	5	to	to	PART
admet-193	412	6	state	state	VERB
admet-193	412	7	the	the	DET
admet-193	412	8	precise	precise	ADJ
admet-193	412	9	concentration	concentration	NOUN
admet-193	412	10	of	of	ADP
admet-193	412	11	the	the	DET
admet-193	412	12	acid	acid	NOUN
admet-193	412	13	used	use	VERB
admet-193	412	14	.	.	PUNCT
admet-193	413	1	record	record	VERB
admet-193	413	2	the	the	DET
admet-193	413	3	precise	precise	ADJ
admet-193	413	4	volume	volume	NOUN
admet-193	413	5	of	of	ADP
admet-193	413	6	ph	ph	ADJ
admet-193	413	7	adjustor	adjustor	NOUN
admet-193	413	8	solution	solution	NOUN
admet-193	413	9	added	add	VERB
admet-193	413	10	.	.	PUNCT
admet-193	414	1	if	if	SCONJ
admet-193	414	2	one	one	PRON
admet-193	414	3	wishes	wish	VERB
admet-193	414	4	to	to	PART
admet-193	414	5	use	use	VERB
admet-193	414	6	ionizable	ionizable	ADJ
admet-193	414	7	titrants	titrant	NOUN
admet-193	414	8	,	,	PUNCT
admet-193	414	9	such	such	ADJ
admet-193	414	10	as	as	ADP
admet-193	414	11	phosphoric	phosphoric	ADJ
admet-193	414	12	acid	acid	NOUN
admet-193	414	13	,	,	PUNCT
admet-193	414	14	acetic	acetic	ADJ
admet-193	414	15	acid	acid	NOUN
admet-193	414	16	,	,	PUNCT
admet-193	414	17	maleic	maleic	VERB
admet-193	414	18	acid	acid	NOUN
admet-193	414	19	,	,	PUNCT
admet-193	414	20	tartaric	tartaric	NOUN
admet-193	414	21	acid	acid	NOUN
admet-193	414	22	,	,	PUNCT
admet-193	414	23	etc	etc	X
admet-193	414	24	.	.	X
admet-193	414	25	,	,	PUNCT
admet-193	414	26	it	it	PRON
admet-193	414	27	may	may	AUX
admet-193	414	28	be	be	AUX
admet-193	414	29	useful	useful	ADJ
admet-193	414	30	to	to	PART
admet-193	414	31	add	add	VERB
admet-193	414	32	enough	enough	ADJ
admet-193	414	33	of	of	ADP
admet-193	414	34	the	the	DET
admet-193	414	35	titrant	titrant	NOUN
admet-193	414	36	so	so	SCONJ
admet-193	414	37	the	the	DET
admet-193	414	38	starting	start	VERB
admet-193	414	39	ph	ph	NOUN
admet-193	414	40	is	be	AUX
admet-193	414	41	as	as	ADV
admet-193	414	42	low	low	ADJ
admet-193	414	43	as	as	SCONJ
admet-193	414	44	desired	desire	VERB
admet-193	414	45	in	in	ADP
admet-193	414	46	the	the	DET
admet-193	414	47	assay	assay	NOUN
admet-193	414	48	.	.	PUNCT
admet-193	415	1	that	that	DET
admet-193	415	2	way	way	NOUN
admet-193	415	3	,	,	PUNCT
admet-193	415	4	the	the	DET
admet-193	415	5	pre	pre	ADJ
admet-193	415	6	-	-	ADJ
admet-193	415	7	acidified	acidify	VERB
admet-193	415	8	solution	solution	NOUN
admet-193	415	9	ph	ph	NOUN
admet-193	415	10	can	can	AUX
admet-193	415	11	be	be	AUX
admet-193	415	12	solely	solely	ADV
admet-193	415	13	regulated	regulate	VERB
admet-193	415	14	by	by	ADP
admet-193	415	15	the	the	DET
admet-193	415	16	amount	amount	NOUN
admet-193	415	17	of	of	ADP
admet-193	415	18	base	base	NOUN
admet-193	415	19	titrant	titrant	NOUN
admet-193	415	20	added	add	VERB
admet-193	415	21	.	.	PUNCT
admet-193	416	1	there	there	PRON
admet-193	416	2	is	be	VERB
admet-193	416	3	no	no	DET
admet-193	416	4	real	real	ADJ
admet-193	416	5	need	need	NOUN
admet-193	416	6	to	to	PART
admet-193	416	7	have	have	AUX
admet-193	416	8	a	a	DET
admet-193	416	9	separate	separate	ADJ
admet-193	416	10	burette	burette	NOUN
admet-193	416	11	dedicated	dedicate	VERB
admet-193	416	12	to	to	ADP
admet-193	416	13	the	the	DET
admet-193	416	14	ionizable	ionizable	ADJ
admet-193	416	15	acid	acid	PROPN
admet-193	416	16	titrant	titrant	NOUN
admet-193	416	17	.	.	PUNCT
admet-193	417	1	result	result	NOUN
admet-193	417	2	computation	computation	NOUN
admet-193	417	3	will	will	AUX
admet-193	417	4	be	be	AUX
admet-193	417	5	greatly	greatly	ADV
admet-193	417	6	simplified	simplify	VERB
admet-193	417	7	.	.	PUNCT
admet-193	418	1	buffers	buffer	NOUN
admet-193	418	2	sufficient	sufficient	ADJ
admet-193	418	3	buffering	buffering	NOUN
admet-193	418	4	is	be	AUX
admet-193	418	5	needed	need	VERB
admet-193	418	6	so	so	SCONJ
admet-193	418	7	that	that	SCONJ
admet-193	418	8	reliable	reliable	ADJ
admet-193	418	9	ph	ph	NOUN
admet-193	418	10	can	can	AUX
admet-193	418	11	be	be	AUX
admet-193	418	12	measured	measure	VERB
admet-193	418	13	and	and	CCONJ
admet-193	418	14	that	that	SCONJ
admet-193	418	15	the	the	DET
admet-193	418	16	titrant	titrant	NOUN
admet-193	418	17	can	can	AUX
admet-193	418	18	be	be	AUX
admet-193	418	19	dispensed	dispense	VERB
admet-193	418	20	precisely	precisely	ADV
admet-193	418	21	enough	enough	ADV
admet-193	418	22	to	to	PART
admet-193	418	23	adjust	adjust	VERB
admet-193	418	24	the	the	DET
admet-193	418	25	solution	solution	NOUN
admet-193	418	26	to	to	ADP
admet-193	418	27	the	the	DET
admet-193	418	28	desired	desire	VERB
admet-193	418	29	ph	ph	NOUN
admet-193	418	30	.	.	PROPN
admet-193	418	31	ordinarily	ordinarily	ADV
admet-193	418	32	,	,	PUNCT
admet-193	418	33	relatively	relatively	ADV
admet-193	418	34	low	low	ADJ
admet-193	418	35	buffer	buffer	NOUN
admet-193	418	36	concentrations	concentration	NOUN
admet-193	418	37	(	(	PUNCT
admet-193	418	38	e.g.	e.g.	ADV
admet-193	418	39	,	,	PUNCT
admet-193	418	40	5	5	NUM
admet-193	418	41	-	-	SYM
admet-193	418	42	10	10	NUM
admet-193	418	43	mm	mm	NOUN
admet-193	418	44	)	)	PUNCT
admet-193	418	45	can	can	AUX
admet-193	418	46	be	be	AUX
admet-193	418	47	recommended	recommend	VERB
admet-193	418	48	.	.	PUNCT
admet-193	419	1	the	the	DET
admet-193	419	2	sample	sample	NOUN
admet-193	419	3	itself	itself	PRON
admet-193	419	4	may	may	AUX
admet-193	419	5	be	be	AUX
admet-193	419	6	an	an	DET
admet-193	419	7	adequate	adequate	ADJ
admet-193	419	8	buffer	buffer	NOUN
admet-193	419	9	.	.	PUNCT
admet-193	420	1	it	it	PRON
admet-193	420	2	is	be	AUX
admet-193	420	3	not	not	PART
admet-193	420	4	beneficial	beneficial	ADJ
admet-193	420	5	to	to	PART
admet-193	420	6	overload	overload	VERB
admet-193	420	7	the	the	DET
admet-193	420	8	assay	assay	NOUN
admet-193	420	9	protocol	protocol	NOUN
admet-193	420	10	with	with	ADP
admet-193	420	11	added	add	VERB
admet-193	420	12	complications	complication	NOUN
admet-193	420	13	arising	arise	VERB
admet-193	420	14	from	from	ADP
admet-193	420	15	possible	possible	ADJ
admet-193	420	16	buffer	buffer	NOUN
admet-193	420	17	-	-	PUNCT
admet-193	420	18	drug	drug	NOUN
admet-193	420	19	interactions	interaction	NOUN
admet-193	420	20	.	.	PUNCT
admet-193	421	1	the	the	DET
admet-193	421	2	use	use	NOUN
admet-193	421	3	of	of	ADP
admet-193	421	4	universal	universal	ADJ
admet-193	421	5	buffers	buffer	NOUN
admet-193	421	6	(	(	PUNCT
admet-193	421	7	e.g.	e.g.	ADV
admet-193	421	8	,	,	PUNCT
admet-193	421	9	britton	britton	PROPN
admet-193	421	10	-	-	PUNCT
admet-193	421	11	robinson	robinson	PROPN
admet-193	421	12	,	,	PUNCT
admet-193	421	13	sorensen	sorensen	PROPN
admet-193	421	14	,	,	PUNCT
admet-193	421	15	mcilvaine	mcilvaine	ADJ
admet-193	421	16	)	)	PUNCT
admet-193	421	17	can	can	AUX
admet-193	421	18	be	be	AUX
admet-193	421	19	very	very	ADV
admet-193	421	20	useful	useful	ADJ
admet-193	421	21	,	,	PUNCT
admet-193	421	22	but	but	CCONJ
admet-193	421	23	it	it	PRON
admet-193	421	24	may	may	AUX
admet-193	421	25	also	also	ADV
admet-193	421	26	be	be	AUX
admet-193	421	27	a	a	DET
admet-193	421	28	source	source	NOUN
admet-193	421	29	of	of	ADP
admet-193	421	30	unintended	unintended	ADJ
admet-193	421	31	/	/	SYM
admet-193	421	32	unnecessary	unnecessary	ADJ
admet-193	421	33	complications	complication	NOUN
admet-193	421	34	when	when	SCONJ
admet-193	421	35	it	it	PRON
admet-193	421	36	comes	come	VERB
admet-193	421	37	to	to	ADP
admet-193	421	38	processing	process	VERB
admet-193	421	39	log	log	NOUN
admet-193	421	40	s	s	PART
admet-193	421	41	–	–	PUNCT
admet-193	421	42	ph	ph	ADJ
admet-193	421	43	data	datum	NOUN
admet-193	421	44	,	,	PUNCT
admet-193	421	45	due	due	ADP
admet-193	421	46	to	to	ADP
admet-193	421	47	drug	drug	NOUN
admet-193	421	48	-	-	PUNCT
admet-193	421	49	buffer	buffer	NOUN
admet-193	421	50	interactions	interaction	NOUN
admet-193	421	51	,	,	PUNCT
admet-193	421	52	particularly	particularly	ADV
admet-193	421	53	when	when	SCONJ
admet-193	421	54	salt	salt	NOUN
admet-193	421	55	solubility	solubility	NOUN
admet-193	421	56	is	be	AUX
admet-193	421	57	measured	measure	VERB
admet-193	421	58	.	.	PUNCT
admet-193	422	1	some	some	DET
admet-193	422	2	buffer	buffer	NOUN
admet-193	422	3	components	component	NOUN
admet-193	422	4	may	may	AUX
admet-193	422	5	cause	cause	VERB
admet-193	422	6	difficulties	difficulty	NOUN
admet-193	422	7	in	in	ADP
admet-193	422	8	uv	uv	NOUN
admet-193	422	9	measurement	measurement	NOUN
admet-193	422	10	.	.	PUNCT
admet-193	423	1	high	high	ADJ
admet-193	423	2	concentration	concentration	NOUN
admet-193	423	3	phosphate	phosphate	NOUN
admet-193	423	4	buffer	buffer	NOUN
admet-193	423	5	is	be	AUX
admet-193	423	6	not	not	PART
admet-193	423	7	recommended	recommend	VERB
admet-193	423	8	;	;	PUNCT
admet-193	423	9	however	however	ADV
admet-193	423	10	drug	drug	NOUN
admet-193	423	11	regulatory	regulatory	ADJ
admet-193	423	12	agencies	agency	NOUN
admet-193	423	13	may	may	AUX
admet-193	423	14	prescribe	prescribe	VERB
admet-193	423	15	it	it	PRON
admet-193	423	16	.	.	PUNCT
admet-193	424	1	it	it	PRON
admet-193	424	2	is	be	AUX
admet-193	424	3	inadequate	inadequate	ADJ
admet-193	424	4	to	to	AUX
admet-193	424	5	state	state	VERB
admet-193	424	6	that	that	SCONJ
admet-193	424	7	“	"	PUNCT
admet-193	424	8	buffers	buffer	NOUN
admet-193	424	9	were	be	AUX
admet-193	424	10	used	use	VERB
admet-193	424	11	”	"	PUNCT
admet-193	424	12	.	.	PUNCT
admet-193	425	1	precisely	precisely	ADV
admet-193	425	2	which	which	DET
admet-193	425	3	buffer	buffer	NOUN
admet-193	425	4	compounds	compound	NOUN
admet-193	425	5	were	be	AUX
admet-193	425	6	used	use	VERB
admet-193	425	7	?	?	PUNCT
admet-193	426	1	which	which	DET
admet-193	426	2	salt	salt	NOUN
admet-193	426	3	forms	form	NOUN
admet-193	426	4	of	of	ADP
admet-193	426	5	buffers	buffer	NOUN
admet-193	426	6	were	be	AUX
admet-193	426	7	used	use	VERB
admet-193	426	8	?	?	PUNCT
admet-193	427	1	at	at	ADP
admet-193	427	2	what	what	DET
admet-193	427	3	concentrations	concentration	NOUN
admet-193	427	4	were	be	AUX
admet-193	427	5	they	they	PRON
admet-193	427	6	prepared	prepare	VERB
admet-193	427	7	?	?	PUNCT
admet-193	428	1	this	this	DET
admet-193	428	2	information	information	NOUN
admet-193	428	3	will	will	AUX
admet-193	428	4	be	be	AUX
admet-193	428	5	needed	need	VERB
admet-193	428	6	to	to	PART
admet-193	428	7	calculate	calculate	VERB
admet-193	428	8	the	the	DET
admet-193	428	9	total	total	ADJ
admet-193	428	10	ionic	ionic	ADJ
admet-193	428	11	strength	strength	NOUN
admet-193	428	12	.	.	PUNCT
admet-193	429	1	it	it	PRON
admet-193	429	2	may	may	AUX
admet-193	429	3	be	be	AUX
admet-193	429	4	a	a	DET
admet-193	429	5	good	good	ADJ
admet-193	429	6	idea	idea	NOUN
admet-193	429	7	to	to	PART
admet-193	429	8	use	use	VERB
admet-193	429	9	zwitterionic	zwitterionic	ADJ
admet-193	429	10	buffers	buffer	NOUN
admet-193	429	11	generally	generally	ADV
admet-193	429	12	,	,	PUNCT
admet-193	429	13	or	or	CCONJ
admet-193	429	14	acid	acid	NOUN
admet-193	429	15	buffers	buffer	NOUN
admet-193	429	16	with	with	ADP
admet-193	429	17	weak	weak	ADJ
admet-193	429	18	acid	acid	NOUN
admet-193	429	19	samples	sample	NOUN
admet-193	429	20	and	and	CCONJ
admet-193	429	21	basic	basic	ADJ
admet-193	429	22	buffers	buffer	NOUN
admet-193	429	23	with	with	ADP
admet-193	429	24	base	base	NOUN
admet-193	429	25	samples	sample	NOUN
admet-193	429	26	.	.	PUNCT
admet-193	430	1	phosphate	phosphate	ADJ
admet-193	430	2	buffers	buffer	NOUN
admet-193	430	3	interact	interact	VERB
admet-193	430	4	with	with	ADP
admet-193	430	5	weak	weak	ADJ
admet-193	430	6	base	base	NOUN
admet-193	430	7	drugs	drug	NOUN
admet-193	430	8	.	.	PUNCT
admet-193	431	1	so	so	ADV
admet-193	431	2	,	,	PUNCT
admet-193	431	3	caution	caution	NOUN
admet-193	431	4	is	be	AUX
admet-193	431	5	needed	need	VERB
admet-193	431	6	when	when	SCONJ
admet-193	431	7	phosphate	phosphate	ADJ
admet-193	431	8	buffers	buffer	NOUN
admet-193	431	9	are	be	AUX
admet-193	431	10	used	use	VERB
admet-193	431	11	with	with	ADP
admet-193	431	12	low	low	ADJ
admet-193	431	13	-	-	PUNCT
admet-193	431	14	soluble	soluble	ADJ
admet-193	431	15	basic	basic	ADJ
admet-193	431	16	drugs	drug	NOUN
admet-193	431	17	.	.	PUNCT
admet-193	432	1	purpose	purpose	NOUN
admet-193	432	2	designed	design	VERB
admet-193	432	3	assays	assay	NOUN
admet-193	432	4	can	can	AUX
admet-193	432	5	better	well	ADV
admet-193	432	6	address	address	VERB
admet-193	432	7	the	the	DET
admet-193	432	8	effect	effect	NOUN
admet-193	432	9	of	of	ADP
admet-193	432	10	phosphate	phosphate	ADJ
admet-193	432	11	anions	anion	NOUN
admet-193	432	12	on	on	ADP
admet-193	432	13	positively	positively	ADV
admet-193	432	14	-	-	PUNCT
admet-193	432	15	charged	charge	VERB
admet-193	432	16	sample	sample	NOUN
admet-193	432	17	molecules	molecule	NOUN
admet-193	432	18	.	.	PUNCT
admet-193	433	1	separating	separate	VERB
admet-193	433	2	solid	solid	ADV
admet-193	433	3	from	from	ADP
admet-193	433	4	saturated	saturate	VERB
admet-193	433	5	solution	solution	NOUN
admet-193	433	6	filtration	filtration	NOUN
admet-193	433	7	can	can	AUX
admet-193	433	8	be	be	AUX
admet-193	433	9	recommended	recommend	VERB
admet-193	433	10	,	,	PUNCT
admet-193	433	11	using	use	VERB
admet-193	433	12	hydrophilic	hydrophilic	ADJ
admet-193	433	13	filters	filter	NOUN
admet-193	433	14	,	,	PUNCT
admet-193	433	15	typically	typically	ADV
admet-193	433	16	0.2	0.2	NUM
admet-193	433	17	-	-	PUNCT
admet-193	433	18	0.45	0.45	NUM
admet-193	433	19	μm	μm	NUM
admet-193	433	20	pore	pore	ADJ
admet-193	433	21	sizes	size	NOUN
admet-193	433	22	.	.	PUNCT
admet-193	434	1	chen	chen	PROPN
admet-193	434	2	et	et	PROPN
admet-193	434	3	al	al	PROPN
admet-193	434	4	.	.	PUNCT
admet-193	435	1	[	[	X
admet-193	435	2	58	58	NUM
admet-193	435	3	]	]	PUNCT
admet-193	435	4	found	find	VERB
admet-193	435	5	the	the	DET
admet-193	435	6	hydrophilic	hydrophilic	ADJ
admet-193	435	7	pvdf	pvdf	PROPN
admet-193	435	8	(	(	PUNCT
admet-193	435	9	polyvinylidene	polyvinylidene	NOUN
admet-193	435	10	fluoride	fluoride	NOUN
admet-193	435	11	)	)	PUNCT
admet-193	435	12	and	and	CCONJ
admet-193	435	13	pes	pe	NOUN
admet-193	435	14	(	(	PUNCT
admet-193	435	15	polyether	polyether	NOUN
admet-193	435	16	sulfone	sulfone	NOUN
admet-193	435	17	)	)	PUNCT
admet-193	435	18	filters	filter	NOUN
admet-193	435	19	performing	perform	VERB
admet-193	435	20	the	the	DET
admet-193	435	21	best	good	ADJ
admet-193	435	22	,	,	PUNCT
admet-193	435	23	and	and	CCONJ
admet-193	435	24	nylon	nylon	NOUN
admet-193	435	25	the	the	DET
admet-193	435	26	worst	bad	ADJ
admet-193	435	27	,	,	PUNCT
admet-193	435	28	in	in	ADP
admet-193	435	29	terms	term	NOUN
admet-193	435	30	of	of	ADP
admet-193	435	31	excessive	excessive	ADJ
admet-193	435	32	compound	compound	NOUN
admet-193	435	33	adsorption	adsorption	NOUN
admet-193	435	34	.	.	PUNCT
admet-193	436	1	it	it	PRON
admet-193	436	2	is	be	AUX
admet-193	436	3	useful	useful	ADJ
admet-193	436	4	to	to	PART
admet-193	436	5	discard	discard	VERB
admet-193	436	6	the	the	DET
admet-193	436	7	first	first	ADJ
admet-193	436	8	1025	1025	NUM
admet-193	436	9	%	%	NOUN
admet-193	436	10	filtered	filter	VERB
admet-193	436	11	solution	solution	NOUN
admet-193	436	12	,	,	PUNCT
admet-193	436	13	to	to	PART
admet-193	436	14	allow	allow	VERB
admet-193	436	15	filters	filter	NOUN
admet-193	436	16	and	and	CCONJ
admet-193	436	17	surfaces	surface	NOUN
admet-193	436	18	to	to	PART
admet-193	436	19	be	be	AUX
admet-193	436	20	saturated	saturate	VERB
admet-193	436	21	with	with	ADP
admet-193	436	22	adsorbed	adsorb	VERB
admet-193	436	23	compound	compound	NOUN
admet-193	436	24	.	.	PUNCT
admet-193	437	1	the	the	DET
admet-193	437	2	filtration	filtration	NOUN
admet-193	437	3	step	step	NOUN
admet-193	437	4	should	should	AUX
admet-193	437	5	not	not	PART
admet-193	437	6	be	be	AUX
admet-193	437	7	rushed	rush	VERB
admet-193	437	8	.	.	PUNCT
admet-193	438	1	if	if	SCONJ
admet-193	438	2	“	"	PUNCT
admet-193	438	3	promiscuous	promiscuous	ADJ
admet-193	438	4	inhibitors	inhibitor	NOUN
admet-193	438	5	”	"	PUNCT
admet-193	438	6	(	(	PUNCT
admet-193	438	7	mcgovern	mcgovern	PROPN
admet-193	438	8	et	et	PROPN
admet-193	438	9	al	al	PROPN
admet-193	438	10	.	.	PUNCT
admet-193	439	1	[	[	X
admet-193	439	2	59	59	NUM
admet-193	439	3	]	]	PUNCT
admet-193	439	4	)	)	PUNCT
admet-193	439	5	are	be	AUX
admet-193	439	6	suspected	suspect	VERB
admet-193	439	7	,	,	PUNCT
admet-193	439	8	then	then	ADV
admet-193	439	9	the	the	DET
admet-193	439	10	filtered	filter	VERB
admet-193	439	11	solutions	solution	NOUN
admet-193	439	12	may	may	AUX
admet-193	439	13	be	be	AUX
admet-193	439	14	further	far	ADV
admet-193	439	15	subjected	subject	VERB
admet-193	439	16	to	to	ADP
admet-193	439	17	ultracentrifugation	ultracentrifugation	NOUN
admet-193	439	18	.	.	PUNCT
admet-193	440	1	it	it	PRON
admet-193	440	2	is	be	AUX
admet-193	440	3	highly	highly	ADV
admet-193	440	4	inadvisable	inadvisable	ADJ
admet-193	440	5	to	to	PART
admet-193	440	6	centrifuge	centrifuge	VERB
admet-193	440	7	first	first	ADV
admet-193	440	8	and	and	CCONJ
admet-193	440	9	then	then	ADV
admet-193	440	10	filter	filter	VERB
admet-193	440	11	,	,	PUNCT
admet-193	440	12	for	for	ADP
admet-193	440	13	reasons	reason	NOUN
admet-193	440	14	discussed	discuss	VERB
admet-193	440	15	in	in	ADP
admet-193	440	16	the	the	DET
admet-193	440	17	review	review	NOUN
admet-193	440	18	.	.	PUNCT
admet-193	441	1	conclusions	conclusion	NOUN
admet-193	441	2	over	over	ADP
admet-193	441	3	800	800	NUM
admet-193	441	4	publications	publication	NOUN
admet-193	441	5	describing	describe	VERB
admet-193	441	6	equilibrium	equilibrium	NOUN
admet-193	441	7	solubility	solubility	NOUN
admet-193	441	8	measurement	measurement	NOUN
admet-193	441	9	of	of	ADP
admet-193	441	10	sparingly	sparingly	ADV
admet-193	441	11	-	-	PUNCT
admet-193	441	12	soluble	soluble	ADJ
admet-193	441	13	ionizable	ionizable	ADJ
admet-193	441	14	drug	drug	NOUN
admet-193	441	15	-	-	PUNCT
admet-193	441	16	like	like	ADJ
admet-193	441	17	molecules	molecule	NOUN
admet-193	441	18	by	by	ADP
admet-193	441	19	the	the	DET
admet-193	441	20	shake	shake	NOUN
admet-193	441	21	-	-	PUNCT
admet-193	441	22	flask	flask	NOUN
admet-193	441	23	and	and	CCONJ
admet-193	441	24	related	related	ADJ
admet-193	441	25	methods	method	NOUN
admet-193	441	26	were	be	AUX
admet-193	441	27	examined	examine	VERB
admet-193	441	28	.	.	PUNCT
admet-193	442	1	many	many	ADJ
admet-193	442	2	factors	factor	NOUN
admet-193	442	3	affecting	affect	VERB
admet-193	442	4	the	the	DET
admet-193	442	5	quality	quality	NOUN
admet-193	442	6	of	of	ADP
admet-193	442	7	the	the	DET
admet-193	442	8	measurement	measurement	NOUN
admet-193	442	9	were	be	AUX
admet-193	442	10	identified	identify	VERB
admet-193	442	11	,	,	PUNCT
admet-193	442	12	and	and	CCONJ
admet-193	442	13	a	a	DET
admet-193	442	14	number	number	NOUN
admet-193	442	15	of	of	ADP
admet-193	442	16	suggestions	suggestion	NOUN
admet-193	442	17	were	be	AUX
admet-193	442	18	offered	offer	VERB
admet-193	442	19	to	to	PART
admet-193	442	20	improve	improve	VERB
admet-193	442	21	the	the	DET
admet-193	442	22	methodology	methodology	NOUN
admet-193	442	23	.	.	PUNCT
admet-193	443	1	some	some	PRON
admet-193	443	2	of	of	ADP
admet-193	443	3	the	the	DET
admet-193	443	4	suggestions	suggestion	NOUN
admet-193	443	5	focused	focus	VERB
admet-193	443	6	on	on	ADP
admet-193	443	7	improving	improve	VERB
admet-193	443	8	methods	method	NOUN
admet-193	443	9	for	for	ADP
admet-193	443	10	future	future	ADJ
admet-193	443	11	measurements	measurement	NOUN
admet-193	443	12	,	,	PUNCT
admet-193	443	13	and	and	CCONJ
admet-193	443	14	some	some	PRON
admet-193	443	15	referred	refer	VERB
admet-193	443	16	to	to	ADP
admet-193	443	17	ways	way	NOUN
admet-193	443	18	of	of	ADP
admet-193	443	19	extracting	extract	VERB
admet-193	443	20	more	more	ADV
admet-193	443	21	reliable	reliable	ADJ
admet-193	443	22	information	information	NOUN
admet-193	443	23	from	from	ADP
admet-193	443	24	existing	exist	VERB
admet-193	443	25	measurements	measurement	NOUN
admet-193	443	26	.	.	PUNCT
admet-193	444	1	by	by	ADP
admet-193	444	2	normalizing	normalize	VERB
admet-193	444	3	data	datum	NOUN
admet-193	444	4	for	for	ADP
admet-193	444	5	ph	ph	NOUN
admet-193	444	6	(	(	PUNCT
admet-193	444	7	by	by	ADP
admet-193	444	8	using	use	VERB
admet-193	444	9	intrinsic	intrinsic	ADJ
admet-193	444	10	solubility	solubility	NOUN
admet-193	444	11	,	,	PUNCT
admet-193	444	12	s0	s0	PROPN
admet-193	444	13	,	,	PUNCT
admet-193	444	14	derived	derive	VERB
admet-193	444	15	from	from	ADP
admet-193	444	16	water	water	NOUN
admet-193	444	17	solubility	solubility	PROPN
admet-193	444	18	,	,	PUNCT
admet-193	444	19	sw	sw	PROPN
admet-193	444	20	)	)	PUNCT
admet-193	444	21	and	and	CCONJ
admet-193	444	22	temperature	temperature	NOUN
admet-193	444	23	effects	effect	NOUN
admet-193	444	24	(	(	PUNCT
admet-193	444	25	by	by	ADP
admet-193	444	26	admet	admet	PROPN
admet-193	444	27	&	&	CCONJ
admet-193	444	28	dmpk	dmpk	PROPN
admet-193	444	29	3(2	3(2	NUM
admet-193	444	30	)	)	PUNCT
admet-193	444	31	(	(	PUNCT
admet-193	444	32	2015	2015	NUM
admet-193	444	33	)	)	PUNCT
admet-193	444	34	84	84	NUM
admet-193	444	35	-	-	SYM
admet-193	444	36	109	109	NUM
admet-193	444	37	equilibrium	equilibrium	NOUN
admet-193	444	38	solubility	solubility	NOUN
admet-193	444	39	measurements	measurement	NOUN
admet-193	444	40	improvements	improvement	NOUN
admet-193	444	41	doi	doi	NOUN
admet-193	444	42	:	:	PUNCT
admet-193	444	43	10.5599	10.5599	NUM
admet-193	444	44	/	/	SYM
admet-193	444	45	admet.3.2.193	admet.3.2.193	X
admet-193	444	46	101	101	NUM
admet-193	444	47	transforming	transform	VERB
admet-193	444	48	measurements	measurement	NOUN
admet-193	444	49	performed	perform	VERB
admet-193	444	50	in	in	ADP
admet-193	444	51	the	the	DET
admet-193	444	52	range	range	NOUN
admet-193	444	53	20	20	NUM
admet-193	444	54	–	–	SYM
admet-193	444	55	40	40	NUM
admet-193	444	56	°	°	ADP
admet-193	444	57	c	c	NOUN
admet-193	444	58	to	to	ADP
admet-193	444	59	the	the	DET
admet-193	444	60	standard	standard	ADJ
admet-193	444	61	value	value	NOUN
admet-193	444	62	of	of	ADP
admet-193	444	63	25	25	NUM
admet-193	444	64	°	°	NOUN
admet-193	444	65	c	c	NOUN
admet-193	444	66	)	)	PUNCT
admet-193	444	67	,	,	PUNCT
admet-193	444	68	it	it	PRON
admet-193	444	69	can	can	AUX
admet-193	444	70	be	be	AUX
admet-193	444	71	demonstrated	demonstrate	VERB
admet-193	444	72	that	that	SCONJ
admet-193	444	73	the	the	DET
admet-193	444	74	expected	expect	VERB
admet-193	444	75	interlaboratory	interlaboratory	ADJ
admet-193	444	76	reproducibility	reproducibility	NOUN
admet-193	444	77	of	of	ADP
admet-193	444	78	0.7	0.7	NUM
admet-193	444	79	log	log	NOUN
admet-193	444	80	unit	unit	NOUN
admet-193	444	81	can	can	AUX
admet-193	444	82	be	be	AUX
admet-193	444	83	reduced	reduce	VERB
admet-193	444	84	to	to	ADP
admet-193	444	85	near	near	ADP
admet-193	444	86	0.15	0.15	NUM
admet-193	444	87	.	.	PUNCT
admet-193	445	1	glossary	glossary	NOUN
admet-193	445	2	dtt	dtt	PROPN
admet-193	445	3	dissolution	dissolution	PROPN
admet-193	445	4	titration	titration	NOUN
admet-193	445	5	template	template	NOUN
admet-193	445	6	potentiometric	potentiometric	ADJ
admet-193	445	7	method	method	NOUN
admet-193	445	8	used	use	VERB
admet-193	445	9	to	to	PART
admet-193	445	10	determine	determine	VERB
admet-193	445	11	intrinsic	intrinsic	ADJ
admet-193	445	12	solubility	solubility	NOUN
admet-193	445	13	,	,	PUNCT
admet-193	445	14	s0	s0	PROPN
admet-193	445	15	sf	sf	PROPN
admet-193	445	16	shake	shake	NOUN
admet-193	445	17	-	-	PUNCT
admet-193	445	18	flask	flask	NOUN
admet-193	445	19	method	method	NOUN
admet-193	445	20	,	,	PUNCT
admet-193	445	21	the	the	DET
admet-193	445	22	“	"	PUNCT
admet-193	445	23	gold	gold	ADJ
admet-193	445	24	standard	standard	NOUN
admet-193	445	25	”	"	PUNCT
admet-193	445	26	solubility	solubility	NOUN
admet-193	445	27	measurement	measurement	NOUN
admet-193	445	28	method	method	PROPN
admet-193	445	29	hh	hh	PROPN
admet-193	445	30	henderson	henderson	PROPN
admet-193	445	31	-	-	PUNCT
admet-193	445	32	hasselbalch	hasselbalch	PROPN
admet-193	445	33	equation	equation	NOUN
admet-193	445	34	(	(	PUNCT
admet-193	445	35	e.g.	e.g.	ADV
admet-193	445	36	,	,	PUNCT
admet-193	445	37	eq	eq	NOUN
admet-193	445	38	.	.	NOUN
admet-193	445	39	1	1	NUM
admet-193	445	40	)	)	PUNCT
admet-193	445	41	kn	kn	PROPN
admet-193	445	42	aggregation	aggregation	NOUN
admet-193	445	43	constant	constant	ADJ
admet-193	445	44	,	,	PUNCT
admet-193	445	45	where	where	SCONJ
admet-193	445	46	n	n	PRON
admet-193	445	47	is	be	AUX
admet-193	445	48	the	the	DET
admet-193	445	49	degree	degree	NOUN
admet-193	445	50	of	of	ADP
admet-193	445	51	aggregation	aggregation	NOUN
admet-193	445	52	pka	pka	PROPN
admet-193	445	53	negative	negative	ADJ
admet-193	445	54	logarithm	logarithm	NOUN
admet-193	445	55	of	of	ADP
admet-193	445	56	the	the	DET
admet-193	445	57	ionization	ionization	NOUN
admet-193	445	58	constant	constant	NOUN
admet-193	445	59	phsat	phsat	VERB
admet-193	445	60	the	the	DET
admet-193	445	61	equilibrium	equilibrium	NOUN
admet-193	445	62	ph	ph	NOUN
admet-193	445	63	of	of	ADP
admet-193	445	64	a	a	DET
admet-193	445	65	saturated	saturate	VERB
admet-193	445	66	solution	solution	NOUN
admet-193	445	67	s	s	PART
admet-193	445	68	solubility	solubility	NOUN
admet-193	445	69	,	,	PUNCT
admet-193	445	70	ideally	ideally	ADV
admet-193	445	71	expressed	express	VERB
admet-193	445	72	in	in	ADP
admet-193	445	73	units	unit	NOUN
admet-193	445	74	of	of	ADP
admet-193	445	75	mol	mol	PROPN
admet-193	445	76	/	/	SYM
admet-193	445	77	l	l	NOUN
admet-193	445	78	(	(	PUNCT
admet-193	445	79	m	m	PROPN
admet-193	445	80	)	)	PUNCT
admet-193	445	81	,	,	PUNCT
admet-193	445	82	μg	μg	PROPN
admet-193	445	83	/	/	SYM
admet-193	445	84	ml	ml	PROPN
admet-193	445	85	,	,	PUNCT
admet-193	445	86	or	or	CCONJ
admet-193	445	87	mg	mg	PROPN
admet-193	445	88	/	/	SYM
admet-193	445	89	ml	ml	NOUN
admet-193	445	90	s0	s0	NOUN
admet-193	445	91	“	"	PUNCT
admet-193	445	92	intrinsic	intrinsic	ADJ
admet-193	445	93	”	"	PUNCT
admet-193	445	94	solubility	solubility	NOUN
admet-193	445	95	(	(	PUNCT
admet-193	445	96	i.e.	i.e.	X
admet-193	445	97	,	,	PUNCT
admet-193	445	98	the	the	DET
admet-193	445	99	solubility	solubility	NOUN
admet-193	445	100	of	of	ADP
admet-193	445	101	the	the	DET
admet-193	445	102	uncharged	uncharged	ADJ
admet-193	445	103	form	form	NOUN
admet-193	445	104	of	of	ADP
admet-193	445	105	the	the	DET
admet-193	445	106	compound	compound	NOUN
admet-193	445	107	)	)	PUNCT
admet-193	445	108	sw	sw	PROPN
admet-193	445	109	“	"	PUNCT
admet-193	445	110	water	water	NOUN
admet-193	445	111	”	"	PUNCT
admet-193	445	112	solubility	solubility	NOUN
admet-193	445	113	,	,	PUNCT
admet-193	445	114	defined	define	VERB
admet-193	445	115	by	by	ADP
admet-193	445	116	dissolving	dissolve	VERB
admet-193	445	117	enough	enough	ADJ
admet-193	445	118	pure	pure	ADJ
admet-193	445	119	free	free	ADJ
admet-193	445	120	acid	acid	NOUN
admet-193	445	121	/	/	SYM
admet-193	445	122	base	base	NOUN
admet-193	445	123	in	in	ADP
admet-193	445	124	distilled	distil	VERB
admet-193	445	125	water	water	NOUN
admet-193	445	126	(	(	PUNCT
admet-193	445	127	or	or	CCONJ
admet-193	445	128	water	water	NOUN
admet-193	445	129	containing	contain	VERB
admet-193	445	130	an	an	DET
admet-193	445	131	inert	inert	ADJ
admet-193	445	132	salt	salt	NOUN
admet-193	445	133	as	as	ADP
admet-193	445	134	ionic	ionic	ADJ
admet-193	445	135	strength	strength	NOUN
admet-193	445	136	adjustor	adjustor	NOUN
admet-193	445	137	)	)	PUNCT
admet-193	445	138	to	to	PART
admet-193	445	139	form	form	VERB
admet-193	445	140	a	a	DET
admet-193	445	141	saturated	saturate	VERB
admet-193	445	142	solution	solution	NOUN
admet-193	445	143	.	.	PUNCT
admet-193	446	1	the	the	DET
admet-193	446	2	final	final	ADJ
admet-193	446	3	ph	ph	NOUN
admet-193	446	4	of	of	ADP
admet-193	446	5	the	the	DET
admet-193	446	6	suspension	suspension	NOUN
admet-193	446	7	,	,	PUNCT
admet-193	446	8	phsat	phsat	NOUN
admet-193	446	9	,	,	PUNCT
admet-193	446	10	and	and	CCONJ
admet-193	446	11	s0	s0	PROPN
admet-193	446	12	can	can	AUX
admet-193	446	13	be	be	AUX
admet-193	446	14	calculated	calculate	VERB
admet-193	446	15	by	by	ADP
admet-193	446	16	the	the	DET
admet-193	446	17	hh	hh	PROPN
admet-193	446	18	equation	equation	NOUN
admet-193	446	19	(	(	PUNCT
admet-193	446	20	when	when	SCONJ
admet-193	446	21	valid	valid	ADJ
admet-193	446	22	)	)	PUNCT
admet-193	446	23	,	,	PUNCT
admet-193	446	24	provided	provide	VERB
admet-193	446	25	the	the	DET
admet-193	446	26	true	true	ADJ
admet-193	446	27	pka	pka	PROPN
admet-193	446	28	is	be	AUX
admet-193	446	29	known	know	VERB
admet-193	446	30	.	.	PUNCT
admet-193	447	1	compound	compound	NOUN
admet-193	447	2	added	add	VERB
admet-193	447	3	as	as	ADP
admet-193	447	4	a	a	DET
admet-193	447	5	salt	salt	NOUN
admet-193	447	6	form	form	NOUN
admet-193	447	7	may	may	AUX
admet-193	447	8	disproportionate	disproportionate	VERB
admet-193	447	9	into	into	ADP
admet-193	447	10	free	free	ADJ
admet-193	447	11	acid	acid	NOUN
admet-193	447	12	/	/	SYM
admet-193	447	13	base	base	NOUN
admet-193	447	14	,	,	PUNCT
admet-193	447	15	depending	depend	VERB
admet-193	447	16	on	on	ADP
admet-193	447	17	how	how	SCONJ
admet-193	447	18	much	much	ADJ
admet-193	447	19	solid	solid	ADJ
admet-193	447	20	had	have	AUX
admet-193	447	21	been	be	AUX
admet-193	447	22	added	add	VERB
admet-193	447	23	.	.	PUNCT
admet-193	448	1	it	it	PRON
admet-193	448	2	is	be	AUX
admet-193	448	3	not	not	PART
admet-193	448	4	generally	generally	ADV
admet-193	448	5	possible	possible	ADJ
admet-193	448	6	to	to	PART
admet-193	448	7	calculate	calculate	VERB
admet-193	448	8	the	the	DET
admet-193	448	9	ph	ph	NOUN
admet-193	448	10	and	and	CCONJ
admet-193	448	11	s0	s0	PROPN
admet-193	448	12	of	of	ADP
admet-193	448	13	such	such	DET
admet-193	448	14	a	a	DET
admet-193	448	15	drug	drug	NOUN
admet-193	448	16	salt	salt	NOUN
admet-193	448	17	suspension	suspension	NOUN
admet-193	448	18	.	.	PUNCT
admet-193	449	1	sph	sph	NOUN
admet-193	449	2	“	"	PUNCT
admet-193	449	3	ph	ph	ADJ
admet-193	449	4	buffer	buffer	NOUN
admet-193	449	5	”	"	PUNCT
admet-193	449	6	solubility	solubility	NOUN
admet-193	449	7	(	(	PUNCT
admet-193	449	8	i.e.	i.e.	X
admet-193	449	9	,	,	PUNCT
admet-193	449	10	the	the	DET
admet-193	449	11	total	total	ADJ
admet-193	449	12	solubility	solubility	NOUN
admet-193	449	13	of	of	ADP
admet-193	449	14	the	the	DET
admet-193	449	15	compound	compound	NOUN
admet-193	449	16	at	at	ADP
admet-193	449	17	a	a	DET
admet-193	449	18	well	well	ADV
admet-193	449	19	-	-	PUNCT
admet-193	449	20	defined	define	VERB
admet-193	449	21	phsat	phsat	NOUN
admet-193	449	22	)	)	PUNCT
admet-193	449	23	acknowledgements	acknowledgement	VERB
admet-193	449	24	helpful	helpful	ADJ
admet-193	449	25	discussions	discussion	NOUN
admet-193	449	26	with	with	ADP
admet-193	449	27	antonio	antonio	PROPN
admet-193	449	28	llinàs	llinàs	PROPN
admet-193	449	29	(	(	PUNCT
admet-193	449	30	astrazeneca	astrazeneca	PROPN
admet-193	449	31	)	)	PUNCT
admet-193	449	32	,	,	PUNCT
admet-193	449	33	krisztina	krisztina	PROPN
admet-193	449	34	takács	takács	PROPN
admet-193	449	35	-	-	PUNCT
admet-193	449	36	novák	novák	NOUN
admet-193	449	37	and	and	CCONJ
admet-193	449	38	gergely	gergely	ADV
admet-193	449	39	völgyi	völgyi	ADV
admet-193	449	40	(	(	PUNCT
admet-193	449	41	semmelweis	semmelweis	PROPN
admet-193	449	42	university	university	NOUN
admet-193	449	43	,	,	PUNCT
admet-193	449	44	budapest	budapest	PROPN
admet-193	449	45	)	)	PUNCT
admet-193	449	46	,	,	PUNCT
admet-193	449	47	christel	christel	PROPN
admet-193	449	48	bergström	bergström	PROPN
admet-193	449	49	(	(	PUNCT
admet-193	449	50	uppsala	uppsala	PROPN
admet-193	449	51	university	university	PROPN
admet-193	449	52	)	)	PUNCT
admet-193	449	53	,	,	PUNCT
admet-193	449	54	and	and	CCONJ
admet-193	449	55	tatjana	tatjana	PROPN
admet-193	449	56	verbić	verbić	PROPN
admet-193	449	57	(	(	PUNCT
admet-193	449	58	university	university	NOUN
admet-193	449	59	of	of	ADP
admet-193	449	60	belgrade	belgrade	PROPN
admet-193	449	61	)	)	PUNCT
admet-193	449	62	are	be	AUX
admet-193	449	63	much	much	ADV
admet-193	449	64	appreciated	appreciated	ADJ
admet-193	449	65	.	.	PUNCT
admet-193	450	1	we	we	PRON
admet-193	450	2	are	be	AUX
admet-193	450	3	greatly	greatly	ADV
admet-193	450	4	indebted	indebted	ADJ
admet-193	450	5	to	to	ADP
admet-193	450	6	agustin	agustin	PROPN
admet-193	450	7	g.	g.	PROPN
admet-193	450	8	asuero	asuero	PROPN
admet-193	450	9	(	(	PUNCT
admet-193	450	10	univ	univ	PROPN
admet-193	450	11	.	.	PROPN
admet-193	450	12	of	of	ADP
admet-193	450	13	seville	seville	PROPN
admet-193	450	14	)	)	PUNCT
admet-193	450	15	,	,	PUNCT
admet-193	450	16	michael	michael	PROPN
admet-193	450	17	h.	h.	PROPN
admet-193	450	18	abraham	abraham	PROPN
admet-193	450	19	(	(	PUNCT
admet-193	450	20	university	university	NOUN
admet-193	450	21	of	of	ADP
admet-193	450	22	london	london	PROPN
admet-193	450	23	)	)	PUNCT
admet-193	450	24	,	,	PUNCT
admet-193	450	25	and	and	CCONJ
admet-193	450	26	william	william	PROPN
admet-193	450	27	e.	e.	PROPN
admet-193	450	28	acree	acree	PROPN
admet-193	450	29	,	,	PUNCT
admet-193	450	30	jr	jr	PROPN
admet-193	450	31	.	.	PROPN
admet-193	450	32	(	(	PUNCT
admet-193	450	33	univ	univ	PROPN
admet-193	450	34	.	.	PROPN
admet-193	450	35	of	of	ADP
admet-193	450	36	n.	n.	PROPN
admet-193	450	37	texas	texas	PROPN
admet-193	450	38	)	)	PUNCT
admet-193	450	39	for	for	ADP
admet-193	450	40	pointing	point	VERB
admet-193	450	41	out	out	ADP
admet-193	450	42	many	many	ADJ
admet-193	450	43	important	important	ADJ
admet-193	450	44	log	log	NOUN
admet-193	450	45	s	s	NOUN
admet-193	450	46	-	-	PUNCT
admet-193	450	47	ph	ph	ADJ
admet-193	450	48	publications	publication	NOUN
admet-193	450	49	.	.	PUNCT
admet-193	451	1	uko	uko	PROPN
admet-193	451	2	maran	maran	PROPN
admet-193	451	3	(	(	PUNCT
admet-193	451	4	univ	univ	PROPN
admet-193	451	5	.	.	PROPN
admet-193	451	6	of	of	ADP
admet-193	451	7	tartu	tartu	NOUN
admet-193	451	8	)	)	PUNCT
admet-193	451	9	,	,	PUNCT
admet-193	451	10	manfred	manfred	PROPN
admet-193	451	11	kansy	kansy	PROPN
admet-193	451	12	,	,	PUNCT
admet-193	451	13	holger	holger	PROPN
admet-193	451	14	fischer	fischer	PROPN
admet-193	451	15	,	,	PUNCT
admet-193	451	16	and	and	CCONJ
admet-193	451	17	stefanie	stefanie	PROPN
admet-193	451	18	bendels	bendel	NOUN
admet-193	451	19	(	(	PUNCT
admet-193	451	20	hoffman	hoffman	NOUN
admet-193	451	21	-	-	PUNCT
admet-193	451	22	la	la	X
admet-193	451	23	roche	roche	NOUN
admet-193	451	24	)	)	PUNCT
admet-193	451	25	have	have	AUX
admet-193	451	26	provided	provide	VERB
admet-193	451	27	valuable	valuable	ADJ
admet-193	451	28	insights	insight	NOUN
admet-193	451	29	and	and	CCONJ
admet-193	451	30	leads	lead	VERB
admet-193	451	31	into	into	ADP
admet-193	451	32	the	the	DET
admet-193	451	33	literature	literature	NOUN
admet-193	451	34	of	of	ADP
admet-193	451	35	chemoinformatics	chemoinformatic	NOUN
admet-193	451	36	,	,	PUNCT
admet-193	451	37	for	for	ADP
admet-193	451	38	which	which	PRON
admet-193	451	39	we	we	PRON
admet-193	451	40	are	be	AUX
admet-193	451	41	grateful	grateful	ADJ
admet-193	451	42	.	.	PUNCT
admet-193	452	1	references	reference	NOUN
admet-193	452	2	[	[	X
admet-193	452	3	1	1	X
admet-193	452	4	]	]	PUNCT
admet-193	452	5	j.	j.	PROPN
admet-193	452	6	huuskonen	huuskonen	PROPN
admet-193	452	7	,	,	PUNCT
admet-193	452	8	m.	m.	PROPN
admet-193	452	9	salo	salo	PROPN
admet-193	452	10	,	,	PUNCT
admet-193	452	11	j.	j.	PROPN
admet-193	452	12	taskinen	taskinen	PROPN
admet-193	452	13	,	,	PUNCT
admet-193	452	14	j.	j.	PROPN
admet-193	452	15	chem	chem	PROPN
admet-193	452	16	.	.	PUNCT
admet-193	453	1	inf	inf	PROPN
admet-193	453	2	.	.	PUNCT
admet-193	454	1	sci	sci	PROPN
admet-193	454	2	.	.	PROPN
admet-193	455	1	38	38	NUM
admet-193	455	2	(	(	PUNCT
admet-193	455	3	1998	1998	NUM
admet-193	455	4	)	)	PUNCT
admet-193	455	5	450	450	NUM
admet-193	455	6	-	-	NUM
admet-193	455	7	456	456	NUM
admet-193	455	8	.	.	PUNCT
admet-193	456	1	[	[	X
admet-193	456	2	2	2	X
admet-193	456	3	]	]	PUNCT
admet-193	456	4	j.	j.	PROPN
admet-193	456	5	huuskonen	huuskonen	PROPN
admet-193	456	6	,	,	PUNCT
admet-193	456	7	j.	j.	PROPN
admet-193	456	8	rantanen	rantanen	PROPN
admet-193	456	9	,	,	PUNCT
admet-193	456	10	d.	d.	PROPN
admet-193	456	11	livingstone	livingstone	PROPN
admet-193	456	12	,	,	PUNCT
admet-193	456	13	eur	eur	PROPN
admet-193	456	14	.	.	PUNCT
admet-193	457	1	j.	j.	PROPN
admet-193	457	2	med	med	PROPN
admet-193	457	3	.	.	PROPN
admet-193	457	4	chem	chem	PROPN
admet-193	457	5	.	.	PUNCT
admet-193	458	1	35	35	NUM
admet-193	458	2	(	(	PUNCT
admet-193	458	3	2000	2000	NUM
admet-193	458	4	)	)	PUNCT
admet-193	458	5	1081	1081	NUM
admet-193	458	6	-	-	SYM
admet-193	458	7	1088	1088	NUM
admet-193	458	8	.	.	PUNCT
admet-193	459	1	[	[	X
admet-193	459	2	3	3	X
admet-193	459	3	]	]	X
admet-193	459	4	m.h	m.h	PROPN
admet-193	459	5	.	.	PROPN
admet-193	459	6	abraham	abraham	PROPN
admet-193	459	7	,	,	PUNCT
admet-193	459	8	j.	j.	PROPN
admet-193	459	9	le	le	PROPN
admet-193	459	10	,	,	PUNCT
admet-193	459	11	j.	j.	PROPN
admet-193	459	12	pharm	pharm	PROPN
admet-193	459	13	.	.	PUNCT
admet-193	460	1	sci	sci	PROPN
admet-193	460	2	.	.	PROPN
admet-193	460	3	88	88	NUM
admet-193	460	4	(	(	PUNCT
admet-193	460	5	1999	1999	NUM
admet-193	460	6	)	)	PUNCT
admet-193	460	7	868	868	NUM
admet-193	460	8	-	-	SYM
admet-193	460	9	880	880	NUM
admet-193	460	10	.	.	PUNCT
admet-193	461	1	[	[	X
admet-193	461	2	4	4	NUM
admet-193	461	3	]	]	X
admet-193	461	4	w.l	w.l	PROPN
admet-193	461	5	.	.	PROPN
admet-193	461	6	jorgensen	jorgensen	PROPN
admet-193	461	7	,	,	PUNCT
admet-193	461	8	e.m	e.m	PROPN
admet-193	461	9	.	.	PROPN
admet-193	461	10	duffy	duffy	PROPN
admet-193	461	11	,	,	PUNCT
admet-193	461	12	bioorg	bioorg	PROPN
admet-193	461	13	.	.	PUNCT
admet-193	462	1	med	med	PROPN
admet-193	462	2	.	.	PROPN
admet-193	462	3	chem	chem	PROPN
admet-193	462	4	.	.	PUNCT
admet-193	463	1	lett	lett	PROPN
admet-193	463	2	.	.	PUNCT
admet-193	464	1	10	10	NUM
admet-193	464	2	(	(	PUNCT
admet-193	464	3	2000	2000	NUM
admet-193	464	4	)	)	PUNCT
admet-193	464	5	1155	1155	NUM
admet-193	464	6	-	-	SYM
admet-193	464	7	1158	1158	NUM
admet-193	464	8	.	.	PUNCT
admet-193	465	1	[	[	X
admet-193	465	2	5	5	NUM
admet-193	465	3	]	]	X
admet-193	465	4	w.l	w.l	PROPN
admet-193	465	5	.	.	PROPN
admet-193	465	6	jorgensen	jorgensen	PROPN
admet-193	465	7	,	,	PUNCT
admet-193	465	8	e.m	e.m	PROPN
admet-193	465	9	.	.	PROPN
admet-193	465	10	duffy	duffy	PROPN
admet-193	465	11	,	,	PUNCT
admet-193	465	12	adv	adv	PROPN
admet-193	465	13	.	.	PUNCT
admet-193	465	14	drug	drug	PROPN
admet-193	465	15	deliv	deliv	PROPN
admet-193	465	16	.	.	PUNCT
admet-193	465	17	rev	rev	PROPN
admet-193	465	18	.	.	PROPN
admet-193	465	19	54	54	NUM
admet-193	465	20	(	(	PUNCT
admet-193	465	21	2002	2002	NUM
admet-193	465	22	)	)	PUNCT
admet-193	466	1	355–366	355–366	NUM
admet-193	466	2	.	.	PUNCT
admet-193	467	1	[	[	X
admet-193	467	2	6	6	NUM
admet-193	467	3	]	]	PUNCT
admet-193	467	4	c.a.s	c.a.s	PROPN
admet-193	467	5	.	.	PUNCT
admet-193	467	6	bergström	bergström	NOUN
admet-193	467	7	,	,	PUNCT
admet-193	467	8	u.	u.	PROPN
admet-193	467	9	norinder	norinder	PROPN
admet-193	467	10	,	,	PUNCT
admet-193	467	11	k.	k.	PROPN
admet-193	467	12	luthman	luthman	PROPN
admet-193	467	13	,	,	PUNCT
admet-193	467	14	p.	p.	PROPN
admet-193	467	15	artursson	artursson	PROPN
admet-193	467	16	,	,	PUNCT
admet-193	467	17	pharm	pharm	PROPN
admet-193	467	18	.	.	PUNCT
admet-193	468	1	res	re	NOUN
admet-193	468	2	.	.	PROPN
admet-193	469	1	19	19	NUM
admet-193	469	2	(	(	PUNCT
admet-193	469	3	2002	2002	NUM
admet-193	469	4	)	)	PUNCT
admet-193	469	5	182	182	NUM
admet-193	469	6	-	-	SYM
admet-193	469	7	188	188	NUM
admet-193	469	8	.	.	PUNCT
admet-193	470	1	[	[	X
admet-193	470	2	7	7	X
admet-193	470	3	]	]	X
admet-193	470	4	t.j	t.j	PROPN
admet-193	470	5	.	.	PROPN
admet-193	470	6	hou	hou	PROPN
admet-193	470	7	,	,	PUNCT
admet-193	470	8	k.	k.	PROPN
admet-193	470	9	xia	xia	PROPN
admet-193	470	10	,	,	PUNCT
admet-193	470	11	w.	w.	PROPN
admet-193	470	12	zhang	zhang	PROPN
admet-193	470	13	,	,	PUNCT
admet-193	470	14	x.j	x.j	PROPN
admet-193	470	15	.	.	PROPN
admet-193	470	16	xu	xu	PROPN
admet-193	470	17	,	,	PUNCT
admet-193	470	18	j.	j.	PROPN
admet-193	470	19	chem	chem	PROPN
admet-193	470	20	.	.	PUNCT
admet-193	471	1	inf	inf	PROPN
admet-193	471	2	.	.	PUNCT
admet-193	471	3	comput	comput	PROPN
admet-193	471	4	.	.	PUNCT
admet-193	472	1	sci	sci	PROPN
admet-193	472	2	.	.	PROPN
admet-193	473	1	44	44	NUM
admet-193	473	2	(	(	PUNCT
admet-193	473	3	2004	2004	NUM
admet-193	473	4	)	)	PUNCT
admet-193	473	5	266	266	NUM
admet-193	473	6	-	-	SYM
admet-193	473	7	275	275	NUM
admet-193	473	8	.	.	PUNCT
admet-193	474	1	[	[	X
admet-193	474	2	8	8	NUM
admet-193	474	3	]	]	X
admet-193	474	4	j.s	j.s	PROPN
admet-193	474	5	.	.	PUNCT
admet-193	474	6	delaney	delaney	PROPN
admet-193	474	7	,	,	PUNCT
admet-193	474	8	drug	drug	NOUN
admet-193	474	9	discov	discov	NOUN
admet-193	474	10	.	.	PUNCT
admet-193	475	1	today	today	NOUN
admet-193	475	2	10	10	NUM
admet-193	475	3	(	(	PUNCT
admet-193	475	4	2005	2005	NUM
admet-193	475	5	)	)	PUNCT
admet-193	475	6	289	289	NUM
admet-193	475	7	-	-	SYM
admet-193	475	8	295	295	NUM
admet-193	475	9	.	.	PUNCT
admet-193	476	1	[	[	X
admet-193	476	2	9	9	NUM
admet-193	476	3	]	]	X
admet-193	476	4	j.c	j.c	PROPN
admet-193	476	5	.	.	PROPN
admet-193	476	6	dearden	dearden	PROPN
admet-193	476	7	,	,	PUNCT
admet-193	476	8	expert	expert	ADJ
admet-193	476	9	opin	opin	NOUN
admet-193	476	10	.	.	PUNCT
admet-193	477	1	drug	drug	NOUN
admet-193	477	2	discov	discov	NOUN
admet-193	477	3	.	.	PUNCT
admet-193	478	1	1	1	NUM
admet-193	478	2	(	(	PUNCT
admet-193	478	3	2006	2006	NUM
admet-193	478	4	)	)	PUNCT
admet-193	478	5	31	31	NUM
admet-193	478	6	-	-	SYM
admet-193	478	7	52	52	NUM
admet-193	478	8	.	.	PUNCT
admet-193	479	1	[	[	X
admet-193	479	2	10	10	NUM
admet-193	479	3	]	]	X
admet-193	479	4	k.v	k.v	PROPN
admet-193	479	5	.	.	PROPN
admet-193	479	6	balakin	balakin	PROPN
admet-193	479	7	,	,	PUNCT
admet-193	479	8	n.p	n.p	PROPN
admet-193	479	9	.	.	PROPN
admet-193	479	10	savchuk	savchuk	PROPN
admet-193	479	11	,	,	PUNCT
admet-193	479	12	i.v	i.v	PROPN
admet-193	479	13	.	.	PUNCT
admet-193	479	14	tetko	tetko	PROPN
admet-193	479	15	,	,	PUNCT
admet-193	479	16	curr	curr	PROPN
admet-193	479	17	.	.	PUNCT
admet-193	479	18	med	med	PROPN
admet-193	479	19	.	.	PROPN
admet-193	479	20	chem	chem	PROPN
admet-193	479	21	.	.	PUNCT
admet-193	480	1	13	13	NUM
admet-193	480	2	(	(	PUNCT
admet-193	480	3	2006	2006	NUM
admet-193	480	4	)	)	PUNCT
admet-193	480	5	223	223	NUM
admet-193	480	6	-	-	SYM
admet-193	480	7	241	241	NUM
admet-193	480	8	.	.	PUNCT
admet-193	481	1	[	[	X
admet-193	481	2	11	11	NUM
admet-193	481	3	]	]	PUNCT
admet-193	481	4	j.	j.	PROPN
admet-193	481	5	taskinen	taskinen	PROPN
admet-193	481	6	,	,	PUNCT
admet-193	481	7	u.	u.	PROPN
admet-193	481	8	norinder	norinder	PROPN
admet-193	481	9	,	,	PUNCT
admet-193	481	10	in	in	ADP
admet-193	481	11	silico	silico	NOUN
admet-193	481	12	predictions	prediction	NOUN
admet-193	481	13	of	of	ADP
admet-193	481	14	solubility	solubility	NOUN
admet-193	481	15	.	.	PUNCT
admet-193	482	1	in	in	ADP
admet-193	482	2	:	:	PUNCT
admet-193	482	3	b.	b.	PROPN
admet-193	482	4	testa	testa	PROPN
admet-193	482	5	,	,	PUNCT
admet-193	482	6	h.	h.	PROPN
admet-193	482	7	van	van	PROPN
admet-193	482	8	de	de	PROPN
admet-193	482	9	waterbeemd	waterbeemd	PROPN
admet-193	482	10	(	(	PUNCT
admet-193	482	11	eds	ed	NOUN
admet-193	482	12	.	.	PUNCT
admet-193	482	13	)	)	PUNCT
admet-193	482	14	.	.	PUNCT
admet-193	483	1	comprehensive	comprehensive	ADJ
admet-193	483	2	medicinal	medicinal	PROPN
admet-193	483	3	chemistry	chemistry	PROPN
admet-193	483	4	ii	ii	PROPN
admet-193	483	5	,	,	PUNCT
admet-193	483	6	elsevier	elsevier	NOUN
admet-193	483	7	:	:	PUNCT
admet-193	483	8	oxford	oxford	PROPN
admet-193	483	9	,	,	PUNCT
admet-193	483	10	uk	uk	PROPN
admet-193	483	11	,	,	PUNCT
admet-193	483	12	2007	2007	NUM
admet-193	483	13	,	,	PUNCT
admet-193	483	14	pp	pp	ADJ
admet-193	483	15	.	.	PUNCT
admet-193	484	1	627	627	NUM
admet-193	484	2	-	-	SYM
admet-193	484	3	648	648	NUM
admet-193	484	4	.	.	PUNCT
admet-193	485	1	avdeef	avdeef	PROPN
admet-193	485	2	admet	admet	PROPN
admet-193	485	3	&	&	CCONJ
admet-193	485	4	dmpk	dmpk	PROPN
admet-193	485	5	3(2	3(2	NUM
admet-193	485	6	)	)	PUNCT
admet-193	485	7	(	(	PUNCT
admet-193	485	8	2015	2015	NUM
admet-193	485	9	)	)	PUNCT
admet-193	485	10	84	84	NUM
admet-193	485	11	-	-	SYM
admet-193	485	12	109	109	NUM
admet-193	485	13	102	102	NUM
admet-193	485	14	[	[	X
admet-193	485	15	12	12	NUM
admet-193	485	16	]	]	PUNCT
admet-193	485	17	p.	p.	NOUN
admet-193	485	18	jain	jain	PROPN
admet-193	485	19	,	,	PUNCT
admet-193	485	20	s.h	s.h	PROPN
admet-193	485	21	.	.	PROPN
admet-193	485	22	yalkowsky	yalkowsky	ADJ
admet-193	485	23	,	,	PUNCT
admet-193	485	24	int	int	NOUN
admet-193	485	25	.	.	PUNCT
admet-193	486	1	j.	j.	PROPN
admet-193	486	2	pharm	pharm	PROPN
admet-193	486	3	.	.	PUNCT
admet-193	487	1	385	385	NUM
admet-193	487	2	(	(	PUNCT
admet-193	487	3	2010	2010	NUM
admet-193	487	4	)	)	PUNCT
admet-193	487	5	1–5	1–5	NUM
admet-193	487	6	.	.	PUNCT
admet-193	488	1	[	[	X
admet-193	488	2	13	13	NUM
admet-193	488	3	]	]	PUNCT
admet-193	488	4	a.	a.	NOUN
admet-193	488	5	shayanfar	shayanfar	PROPN
admet-193	488	6	,	,	PUNCT
admet-193	488	7	a.	a.	PROPN
admet-193	488	8	jouyban	jouyban	PROPN
admet-193	488	9	,	,	PUNCT
admet-193	488	10	lat	lat	PROPN
admet-193	488	11	.	.	PUNCT
admet-193	488	12	am	be	AUX
admet-193	488	13	.	.	PUNCT
admet-193	489	1	j.	j.	PROPN
admet-193	489	2	pharm	pharm	PROPN
admet-193	489	3	.	.	PUNCT
admet-193	490	1	30	30	NUM
admet-193	490	2	(	(	PUNCT
admet-193	490	3	2011	2011	NUM
admet-193	490	4	)	)	PUNCT
admet-193	490	5	1525	1525	NUM
admet-193	490	6	-	-	SYM
admet-193	490	7	1530	1530	NUM
admet-193	490	8	.	.	PUNCT
admet-193	491	1	[	[	X
admet-193	491	2	14	14	NUM
admet-193	491	3	]	]	PUNCT
admet-193	491	4	j.	j.	PROPN
admet-193	491	5	wang	wang	PROPN
admet-193	491	6	,	,	PUNCT
admet-193	491	7	t.	t.	PROPN
admet-193	491	8	hou	hou	PROPN
admet-193	491	9	,	,	PUNCT
admet-193	491	10	combi	combi	PROPN
admet-193	491	11	.	.	PUNCT
admet-193	492	1	chem	chem	PROPN
admet-193	492	2	.	.	PUNCT
admet-193	493	1	high	high	ADJ
admet-193	493	2	throughput	throughput	PROPN
admet-193	493	3	scr	scr	NOUN
admet-193	493	4	.	.	PROPN
admet-193	494	1	14	14	NUM
admet-193	494	2	(	(	PUNCT
admet-193	494	3	2011	2011	NUM
admet-193	494	4	)	)	PUNCT
admet-193	494	5	1	1	NUM
admet-193	494	6	-	-	SYM
admet-193	494	7	11	11	NUM
admet-193	494	8	.	.	PUNCT
admet-193	495	1	[	[	X
admet-193	495	2	15	15	NUM
admet-193	495	3	]	]	X
admet-193	495	4	d.	d.	PROPN
admet-193	495	5	elder	elder	PROPN
admet-193	495	6	,	,	PUNCT
admet-193	495	7	r.	r.	PROPN
admet-193	495	8	holm	holm	PROPN
admet-193	495	9	,	,	PUNCT
admet-193	495	10	int	int	NOUN
admet-193	495	11	.	.	PUNCT
admet-193	496	1	j.	j.	PROPN
admet-193	496	2	pharm	pharm	PROPN
admet-193	496	3	.	.	PUNCT
admet-193	497	1	453	453	NUM
admet-193	497	2	(	(	PUNCT
admet-193	497	3	2013	2013	NUM
admet-193	497	4	)	)	PUNCT
admet-193	497	5	3	3	NUM
admet-193	497	6	-	-	SYM
admet-193	497	7	11	11	NUM
admet-193	497	8	.	.	PUNCT
admet-193	498	1	[	[	X
admet-193	498	2	16	16	NUM
admet-193	498	3	]	]	X
admet-193	498	4	j.l	j.l	PROPN
admet-193	498	5	.	.	PROPN
admet-193	498	6	mcdonagh	mcdonagh	PROPN
admet-193	498	7	,	,	PUNCT
admet-193	498	8	n.	n.	PROPN
admet-193	498	9	nath	nath	PROPN
admet-193	498	10	,	,	PUNCT
admet-193	498	11	l.	l.	PROPN
admet-193	498	12	de	de	PROPN
admet-193	498	13	ferrari	ferrari	PROPN
admet-193	498	14	,	,	PUNCT
admet-193	498	15	t.	t.	PROPN
admet-193	498	16	van	van	PROPN
admet-193	498	17	mourik	mourik	PROPN
admet-193	498	18	,	,	PUNCT
admet-193	498	19	j.b	j.b	PROPN
admet-193	498	20	.	.	PROPN
admet-193	498	21	mitchell	mitchell	PROPN
admet-193	498	22	,	,	PUNCT
admet-193	498	23	j.	j.	PROPN
admet-193	498	24	chem	chem	PROPN
admet-193	498	25	.	.	PUNCT
admet-193	499	1	inf	inf	PROPN
admet-193	499	2	.	.	PROPN
admet-193	499	3	model	model	PROPN
admet-193	499	4	.	.	PUNCT
admet-193	500	1	54	54	NUM
admet-193	500	2	(	(	PUNCT
admet-193	500	3	2014	2014	NUM
admet-193	500	4	)	)	PUNCT
admet-193	500	5	844	844	NUM
admet-193	500	6	-	-	SYM
admet-193	500	7	856	856	NUM
admet-193	500	8	.	.	PUNCT
admet-193	501	1	[	[	X
admet-193	501	2	17	17	NUM
admet-193	501	3	]	]	X
admet-193	501	4	d.s	d.s	PROPN
admet-193	501	5	.	.	PROPN
admet-193	501	6	palmer	palmer	PROPN
admet-193	501	7	,	,	PUNCT
admet-193	501	8	j.b.o	j.b.o	PROPN
admet-193	501	9	.	.	PROPN
admet-193	501	10	mitchell	mitchell	PROPN
admet-193	501	11	,	,	PUNCT
admet-193	501	12	mol	mol	PROPN
admet-193	501	13	.	.	PUNCT
admet-193	501	14	pharmaceutics	pharmaceutic	NOUN
admet-193	501	15	11	11	NUM
admet-193	501	16	(	(	PUNCT
admet-193	501	17	2014	2014	NUM
admet-193	501	18	)	)	PUNCT
admet-193	501	19	2962	2962	NUM
admet-193	501	20	-	-	SYM
admet-193	501	21	2972	2972	NUM
admet-193	501	22	.	.	PUNCT
admet-193	502	1	[	[	X
admet-193	502	2	18	18	NUM
admet-193	502	3	]	]	X
admet-193	502	4	b.	b.	PROPN
admet-193	502	5	faller	faller	PROPN
admet-193	502	6	,	,	PUNCT
admet-193	502	7	p.	p.	PROPN
admet-193	502	8	ertl	ertl	PROPN
admet-193	502	9	,	,	PUNCT
admet-193	502	10	adv	adv	PROPN
admet-193	502	11	.	.	PUNCT
admet-193	502	12	drug	drug	PROPN
admet-193	502	13	deliv	deliv	PROPN
admet-193	502	14	.	.	PUNCT
admet-193	502	15	rev	rev	PROPN
admet-193	502	16	.	.	PROPN
admet-193	502	17	59	59	NUM
admet-193	502	18	(	(	PUNCT
admet-193	502	19	2007	2007	NUM
admet-193	502	20	)	)	PUNCT
admet-193	503	1	533–545	533–545	NUM
admet-193	503	2	.	.	PUNCT
admet-193	504	1	[	[	X
admet-193	504	2	19	19	NUM
admet-193	504	3	]	]	X
admet-193	504	4	s.h	s.h	PROPN
admet-193	504	5	.	.	NOUN
admet-193	504	6	yalkowsky	yalkowsky	ADJ
admet-193	504	7	,	,	PUNCT
admet-193	504	8	y.	y.	PROPN
admet-193	504	9	he	he	PRON
admet-193	504	10	,	,	PUNCT
admet-193	504	11	p.	p.	PROPN
admet-193	504	12	jain	jain	PROPN
admet-193	504	13	,	,	PUNCT
admet-193	504	14	handbook	handbook	NOUN
admet-193	504	15	of	of	ADP
admet-193	504	16	aqueous	aqueous	ADJ
admet-193	504	17	solubility	solubility	NOUN
admet-193	504	18	data	datum	NOUN
admet-193	504	19	,	,	PUNCT
admet-193	504	20	second	second	ADJ
admet-193	504	21	edition	edition	NOUN
admet-193	504	22	.	.	PUNCT
admet-193	505	1	crc	crc	PROPN
admet-193	505	2	press	press	PROPN
admet-193	505	3	,	,	PUNCT
admet-193	505	4	boca	boca	PROPN
admet-193	505	5	raton	raton	PROPN
admet-193	505	6	,	,	PUNCT
admet-193	505	7	fl	fl	PROPN
admet-193	505	8	,	,	PUNCT
admet-193	505	9	2010	2010	NUM
admet-193	505	10	.	.	PUNCT
admet-193	506	1	[	[	X
admet-193	506	2	20	20	NUM
admet-193	506	3	]	]	PUNCT
admet-193	506	4	p.	p.	PROPN
admet-193	506	5	howard	howard	PROPN
admet-193	506	6	,	,	PUNCT
admet-193	506	7	w.	w.	PROPN
admet-193	506	8	meylan	meylan	PROPN
admet-193	506	9	,	,	PUNCT
admet-193	506	10	physprop	physprop	PROPN
admet-193	506	11	database	database	NOUN
admet-193	506	12	.	.	PUNCT
admet-193	507	1	syracuse	syracuse	PROPN
admet-193	507	2	research	research	PROPN
admet-193	507	3	corp	corp	PROPN
admet-193	507	4	.	.	PROPN
admet-193	507	5	,	,	PUNCT
admet-193	507	6	environmental	environmental	ADJ
admet-193	507	7	science	science	NOUN
admet-193	507	8	center	center	NOUN
admet-193	507	9	,	,	PUNCT
admet-193	507	10	n.	n.	PROPN
admet-193	507	11	syracuse	syracuse	PROPN
admet-193	507	12	,	,	PUNCT
admet-193	507	13	ny	ny	PROPN
admet-193	507	14	,	,	PUNCT
admet-193	507	15	sept	sept	PROPN
admet-193	507	16	.	.	PROPN
admet-193	507	17	1999	1999	NUM
admet-193	507	18	.	.	PUNCT
admet-193	508	1	[	[	X
admet-193	508	2	21	21	NUM
admet-193	508	3	]	]	X
admet-193	508	4	syracuse	syracuse	PROPN
admet-193	508	5	research	research	PROPN
admet-193	508	6	corporation	corporation	PROPN
admet-193	508	7	.	.	PUNCT
admet-193	509	1	the	the	DET
admet-193	509	2	physical	physical	ADJ
admet-193	509	3	properties	property	NOUN
admet-193	509	4	database	database	NOUN
admet-193	509	5	(	(	PUNCT
admet-193	509	6	physprop	physprop	PROPN
admet-193	509	7	)	)	PUNCT
admet-193	509	8	http://www.srcinc.com/what-we-do/environmental/scientific-databases.html	http://www.srcinc.com/what-we-do/environmental/scientific-databases.html	NOUN
admet-193	509	9	(	(	PUNCT
admet-193	509	10	accessed	access	VERB
admet-193	509	11	18	18	NUM
admet-193	509	12	feb	feb	NOUN
admet-193	509	13	2015	2015	NUM
admet-193	509	14	)	)	PUNCT
admet-193	509	15	.	.	PUNCT
admet-193	510	1	[	[	X
admet-193	510	2	22	22	NUM
admet-193	510	3	]	]	X
admet-193	510	4	analytical	analytical	ADJ
admet-193	510	5	profiles	profile	NOUN
admet-193	510	6	of	of	ADP
admet-193	510	7	drug	drug	NOUN
admet-193	510	8	substances	substance	NOUN
admet-193	510	9	(	(	PUNCT
admet-193	510	10	analytical	analytical	ADJ
admet-193	510	11	profiles	profile	NOUN
admet-193	510	12	of	of	ADP
admet-193	510	13	drug	drug	NOUN
admet-193	510	14	substances	substance	NOUN
admet-193	510	15	and	and	CCONJ
admet-193	510	16	excipients	excipient	NOUN
admet-193	510	17	;	;	PUNCT
admet-193	510	18	profiles	profile	NOUN
admet-193	510	19	of	of	ADP
admet-193	510	20	drug	drug	NOUN
admet-193	510	21	substances	substance	NOUN
admet-193	510	22	,	,	PUNCT
admet-193	510	23	excipients	excipient	NOUN
admet-193	510	24	and	and	CCONJ
admet-193	510	25	related	relate	VERB
admet-193	510	26	methodology	methodology	NOUN
admet-193	510	27	)	)	PUNCT
admet-193	510	28	.	.	PUNCT
admet-193	511	1	k.	k.	PROPN
admet-193	511	2	florey	florey	PROPN
admet-193	512	1	(	(	PUNCT
admet-193	512	2	ed	ed	NOUN
admet-193	512	3	.	.	PROPN
admet-193	512	4	,	,	PUNCT
admet-193	512	5	vols	vol	NOUN
admet-193	512	6	.	.	PUNCT
admet-193	513	1	1	1	NUM
admet-193	513	2	-	-	SYM
admet-193	513	3	20),h.g	20),h.g	NUM
admet-193	513	4	.	.	PUNCT
admet-193	514	1	brittain	brittain	PROPN
admet-193	514	2	(	(	PUNCT
admet-193	514	3	ed	ed	NOUN
admet-193	514	4	.	.	PROPN
admet-193	514	5	,	,	PUNCT
admet-193	514	6	vols	vol	NOUN
admet-193	514	7	.	.	PUNCT
admet-193	515	1	21	21	NUM
admet-193	515	2	-	-	SYM
admet-193	515	3	39	39	NUM
admet-193	515	4	)	)	PUNCT
admet-193	515	5	.	.	PUNCT
admet-193	516	1	academic	academic	ADJ
admet-193	516	2	press	press	NOUN
admet-193	516	3	,	,	PUNCT
admet-193	516	4	san	san	PROPN
admet-193	516	5	diego	diego	PROPN
admet-193	516	6	,	,	PUNCT
admet-193	516	7	1972	1972	NUM
admet-193	516	8	-	-	SYM
admet-193	516	9	2014	2014	NUM
admet-193	516	10	.	.	PUNCT
admet-193	517	1	[	[	X
admet-193	517	2	23	23	NUM
admet-193	517	3	]	]	X
admet-193	517	4	j.w	j.w	PROPN
admet-193	517	5	.	.	PROPN
admet-193	517	6	mcfarland	mcfarland	PROPN
admet-193	517	7	,	,	PUNCT
admet-193	517	8	a.	a.	PROPN
admet-193	517	9	avdeef	avdeef	PROPN
admet-193	517	10	,	,	PUNCT
admet-193	517	11	c.m	c.m	PROPN
admet-193	517	12	.	.	PROPN
admet-193	517	13	berger	berger	PROPN
admet-193	517	14	,	,	PUNCT
admet-193	517	15	o.a	o.a	PROPN
admet-193	517	16	.	.	PROPN
admet-193	517	17	raevsky	raevsky	PROPN
admet-193	517	18	,	,	PUNCT
admet-193	517	19	j.	j.	PROPN
admet-193	517	20	chem	chem	PROPN
admet-193	517	21	.	.	PUNCT
admet-193	518	1	inf	inf	PROPN
admet-193	518	2	.	.	PUNCT
admet-193	518	3	comput	comput	PROPN
admet-193	518	4	.	.	PUNCT
admet-193	519	1	sci	sci	PROPN
admet-193	519	2	.	.	PROPN
admet-193	520	1	41	41	NUM
admet-193	520	2	(	(	PUNCT
admet-193	520	3	2001	2001	NUM
admet-193	520	4	)	)	PUNCT
admet-193	520	5	13551359	13551359	NUM
admet-193	520	6	.	.	PUNCT
admet-193	521	1	[	[	X
admet-193	521	2	24	24	NUM
admet-193	521	3	]	]	X
admet-193	521	4	e.	e.	PROPN
admet-193	521	5	rytting	rytting	PROPN
admet-193	521	6	,	,	PUNCT
admet-193	521	7	k.a	k.a	PROPN
admet-193	521	8	.	.	PROPN
admet-193	521	9	lentz	lentz	PROPN
admet-193	521	10	,	,	PUNCT
admet-193	521	11	x.q	x.q	PROPN
admet-193	521	12	.	.	PROPN
admet-193	521	13	chen	chen	PROPN
admet-193	521	14	,	,	PUNCT
admet-193	521	15	f.	f.	PROPN
admet-193	521	16	qian	qian	PROPN
admet-193	521	17	,	,	PUNCT
admet-193	521	18	s.	s.	PROPN
admet-193	521	19	venkatesh	venkatesh	PROPN
admet-193	521	20	,	,	PUNCT
admet-193	521	21	pharm	pharm	NOUN
admet-193	521	22	res	re	NOUN
admet-193	521	23	.	.	PUNCT
admet-193	521	24	21	21	NUM
admet-193	521	25	(	(	PUNCT
admet-193	521	26	2004	2004	NUM
admet-193	521	27	)	)	PUNCT
admet-193	521	28	237	237	NUM
admet-193	521	29	-	-	SYM
admet-193	521	30	244	244	NUM
admet-193	521	31	.	.	PUNCT
admet-193	522	1	[	[	X
admet-193	522	2	25	25	NUM
admet-193	522	3	]	]	PUNCT
admet-193	522	4	c.a.s	c.a.s	PROPN
admet-193	522	5	.	.	PROPN
admet-193	522	6	bergström	bergström	PROPN
admet-193	522	7	,	,	PUNCT
admet-193	522	8	c.m	c.m	PROPN
admet-193	522	9	.	.	PROPN
admet-193	522	10	wassvik	wassvik	PROPN
admet-193	522	11	,	,	PUNCT
admet-193	522	12	u.	u.	PROPN
admet-193	522	13	norinder	norinder	PROPN
admet-193	522	14	,	,	PUNCT
admet-193	522	15	k.	k.	PROPN
admet-193	522	16	luthman	luthman	PROPN
admet-193	522	17	,	,	PUNCT
admet-193	522	18	p.	p.	PROPN
admet-193	522	19	artursson	artursson	PROPN
admet-193	522	20	,	,	PUNCT
admet-193	522	21	j.	j.	PROPN
admet-193	522	22	chem	chem	PROPN
admet-193	522	23	.	.	PUNCT
admet-193	523	1	inf	inf	PROPN
admet-193	523	2	.	.	PUNCT
admet-193	523	3	comput	comput	PROPN
admet-193	523	4	.	.	PUNCT
admet-193	524	1	sci	sci	PROPN
admet-193	524	2	.	.	PROPN
admet-193	525	1	44	44	NUM
admet-193	525	2	(	(	PUNCT
admet-193	525	3	2004	2004	NUM
admet-193	525	4	)	)	PUNCT
admet-193	525	5	1477	1477	NUM
admet-193	525	6	-	-	SYM
admet-193	525	7	1488	1488	NUM
admet-193	525	8	.	.	PUNCT
admet-193	526	1	[	[	X
admet-193	526	2	26	26	NUM
admet-193	526	3	]	]	PUNCT
admet-193	526	4	a.	a.	NOUN
admet-193	526	5	llinàs	llinàs	PROPN
admet-193	526	6	,	,	PUNCT
admet-193	526	7	r.c	r.c	PROPN
admet-193	526	8	.	.	PROPN
admet-193	526	9	glen	glen	PROPN
admet-193	526	10	,	,	PUNCT
admet-193	526	11	j.m	j.m	PROPN
admet-193	526	12	.	.	PROPN
admet-193	526	13	goodman	goodman	PROPN
admet-193	526	14	,	,	PUNCT
admet-193	526	15	j.	j.	PROPN
admet-193	526	16	chem	chem	PROPN
admet-193	526	17	.	.	PUNCT
admet-193	527	1	inf	inf	PROPN
admet-193	527	2	.	.	PROPN
admet-193	527	3	model	model	PROPN
admet-193	527	4	.	.	PUNCT
admet-193	528	1	48	48	NUM
admet-193	528	2	(	(	PUNCT
admet-193	528	3	2008	2008	NUM
admet-193	528	4	)	)	PUNCT
admet-193	528	5	1289–1303	1289–1303	NUM
admet-193	528	6	.	.	PUNCT
admet-193	529	1	[	[	X
admet-193	529	2	27	27	NUM
admet-193	529	3	]	]	X
admet-193	529	4	a.j	a.j	PROPN
admet-193	529	5	.	.	PROPN
admet-193	529	6	hopfinger	hopfinger	PROPN
admet-193	529	7	,	,	PUNCT
admet-193	529	8	e.x	e.x	PROPN
admet-193	529	9	.	.	PROPN
admet-193	529	10	esposito	esposito	PROPN
admet-193	529	11	,	,	PUNCT
admet-193	529	12	a.	a.	PROPN
admet-193	529	13	llinàs	llinàs	PROPN
admet-193	529	14	,	,	PUNCT
admet-193	529	15	r.c	r.c	PROPN
admet-193	529	16	.	.	PROPN
admet-193	529	17	glen	glen	PROPN
admet-193	529	18	,	,	PUNCT
admet-193	529	19	j.m	j.m	PROPN
admet-193	529	20	.	.	PROPN
admet-193	529	21	goodman	goodman	PROPN
admet-193	529	22	,	,	PUNCT
admet-193	529	23	j.	j.	PROPN
admet-193	529	24	chem	chem	PROPN
admet-193	529	25	.	.	PUNCT
admet-193	530	1	inf	inf	PROPN
admet-193	530	2	.	.	PROPN
admet-193	530	3	model	model	PROPN
admet-193	530	4	.	.	PUNCT
admet-193	531	1	49	49	NUM
admet-193	531	2	(	(	PUNCT
admet-193	531	3	2009	2009	NUM
admet-193	531	4	)	)	PUNCT
admet-193	531	5	1	1	NUM
admet-193	531	6	-	-	SYM
admet-193	531	7	5	5	NUM
admet-193	531	8	.	.	PUNCT
admet-193	532	1	[	[	X
admet-193	532	2	28	28	NUM
admet-193	532	3	]	]	X
admet-193	532	4	w.p	w.p	PROPN
admet-193	532	5	.	.	PROPN
admet-193	532	6	walters	walters	PROPN
admet-193	532	7	,	,	PUNCT
admet-193	532	8	what	what	PRON
admet-193	532	9	are	be	AUX
admet-193	532	10	our	our	PRON
admet-193	532	11	models	model	NOUN
admet-193	532	12	really	really	ADV
admet-193	532	13	telling	tell	VERB
admet-193	532	14	us	we	PRON
admet-193	532	15	?	?	PUNCT
admet-193	533	1	a	a	DET
admet-193	533	2	practical	practical	ADJ
admet-193	533	3	tutorial	tutorial	NOUN
admet-193	533	4	on	on	ADP
admet-193	533	5	avoiding	avoid	VERB
admet-193	533	6	common	common	ADJ
admet-193	533	7	mistakes	mistake	NOUN
admet-193	533	8	when	when	SCONJ
admet-193	533	9	building	build	VERB
admet-193	533	10	predictive	predictive	ADJ
admet-193	533	11	models	model	NOUN
admet-193	533	12	.	.	PUNCT
admet-193	534	1	in	in	ADP
admet-193	534	2	:	:	PUNCT
admet-193	534	3	j.	j.	PROPN
admet-193	534	4	bajorath	bajorath	PROPN
admet-193	534	5	(	(	PUNCT
admet-193	534	6	ed	ed	NOUN
admet-193	534	7	.	.	PUNCT
admet-193	534	8	)	)	PUNCT
admet-193	534	9	.	.	PUNCT
admet-193	535	1	chemoinformatics	chemoinformatic	NOUN
admet-193	535	2	for	for	ADP
admet-193	535	3	drug	drug	NOUN
admet-193	535	4	discovery	discovery	NOUN
admet-193	535	5	.	.	PUNCT
admet-193	536	1	john	john	PROPN
admet-193	536	2	wiley	wiley	PROPN
admet-193	536	3	&	&	CCONJ
admet-193	536	4	sons	sons	PROPN
admet-193	536	5	,	,	PUNCT
admet-193	536	6	hoboken	hoboken	PROPN
admet-193	536	7	,	,	PUNCT
admet-193	536	8	nj	nj	PROPN
admet-193	536	9	,	,	PUNCT
admet-193	536	10	2014	2014	NUM
admet-193	536	11	,	,	PUNCT
admet-193	536	12	pp	pp	ADJ
admet-193	536	13	.	.	PUNCT
admet-193	537	1	1	1	NUM
admet-193	537	2	-	-	SYM
admet-193	537	3	31	31	NUM
admet-193	537	4	.	.	PUNCT
admet-193	538	1	[	[	X
admet-193	538	2	29	29	NUM
admet-193	538	3	]	]	X
admet-193	538	4	g.	g.	PROPN
admet-193	538	5	landrum	landrum	PROPN
admet-193	538	6	,	,	PUNCT
admet-193	538	7	r.	r.	PROPN
admet-193	538	8	lewis	lewis	PROPN
admet-193	538	9	,	,	PUNCT
admet-193	538	10	a.	a.	NOUN
admet-193	538	11	palmer	palmer	PROPN
admet-193	538	12	,	,	PUNCT
admet-193	538	13	n.	n.	PROPN
admet-193	538	14	stiefl	stiefl	PROPN
admet-193	538	15	,	,	PUNCT
admet-193	538	16	a.	a.	PROPN
admet-193	538	17	vulpetti	vulpetti	PROPN
admet-193	538	18	,	,	PUNCT
admet-193	538	19	j.	j.	PROPN
admet-193	538	20	cheminform	cheminform	PROPN
admet-193	538	21	.	.	PUNCT
admet-193	539	1	3	3	NUM
admet-193	539	2	(	(	PUNCT
admet-193	539	3	2011	2011	NUM
admet-193	539	4	)	)	PUNCT
admet-193	539	5	1	1	NUM
admet-193	539	6	-	-	SYM
admet-193	539	7	1	1	NUM
admet-193	539	8	.	.	PUNCT
admet-193	540	1	[	[	X
admet-193	540	2	30	30	NUM
admet-193	540	3	]	]	X
admet-193	540	4	m.h	m.h	PROPN
admet-193	540	5	.	.	PROPN
admet-193	540	6	abraham	abraham	PROPN
admet-193	540	7	,	,	PUNCT
admet-193	540	8	a.	a.	PROPN
admet-193	540	9	ibrahim	ibrahim	PROPN
admet-193	540	10	,	,	PUNCT
admet-193	540	11	a.m.	a.m.	PROPN
admet-193	540	12	zissimos	zissimos	PROPN
admet-193	540	13	,	,	PUNCT
admet-193	540	14	y.h	y.h	PROPN
admet-193	540	15	.	.	PROPN
admet-193	540	16	zhao	zhao	PROPN
admet-193	540	17	,	,	PUNCT
admet-193	540	18	j.	j.	PROPN
admet-193	540	19	comer	comer	PROPN
admet-193	540	20	,	,	PUNCT
admet-193	540	21	d.p	d.p	PROPN
admet-193	540	22	.	.	PROPN
admet-193	540	23	reynolds	reynolds	PROPN
admet-193	540	24	,	,	PUNCT
admet-193	540	25	drug	drug	NOUN
admet-193	540	26	disc	disc	NOUN
admet-193	540	27	.	.	PUNCT
admet-193	541	1	today	today	NOUN
admet-193	541	2	7	7	NUM
admet-193	541	3	(	(	PUNCT
admet-193	541	4	2002	2002	NUM
admet-193	541	5	)	)	PUNCT
admet-193	541	6	1056	1056	NUM
admet-193	541	7	-	-	SYM
admet-193	541	8	1063	1063	NUM
admet-193	541	9	.	.	PUNCT
admet-193	542	1	[	[	X
admet-193	542	2	31	31	NUM
admet-193	542	3	]	]	PUNCT
admet-193	542	4	a.	a.	PROPN
admet-193	542	5	sid	sid	PROPN
admet-193	542	6	lang	lang	PROPN
admet-193	542	7	,	,	PUNCT
admet-193	542	8	j	j	PROPN
admet-193	542	9	-	-	PROPN
admet-193	542	10	c	c	PROPN
admet-193	542	11	bradley	bradley	PROPN
admet-193	542	12	,	,	PUNCT
admet-193	542	13	ons	ons	PROPN
admet-193	542	14	melting	melting	NOUN
admet-193	542	15	point	point	NOUN
admet-193	542	16	model	model	NOUN
admet-193	542	17	010	010	NUM
admet-193	542	18	.	.	PUNCT
admet-193	543	1	qdb	qdb	PROPN
admet-193	543	2	archive	archive	NOUN
admet-193	543	3	,	,	PUNCT
admet-193	543	4	doi	doi	NOUN
admet-193	543	5	:	:	PUNCT
admet-193	543	6	10.15152	10.15152	NUM
admet-193	543	7	/	/	SYM
admet-193	543	8	qdb.104	qdb.104	PROPN
admet-193	543	9	.	.	PUNCT
admet-193	544	1	qsardb	qsardb	PROPN
admet-193	544	2	content	content	PROPN
admet-193	544	3	.	.	PUNCT
admet-193	545	1	property	property	NOUN
admet-193	545	2	mpc	mpc	PROPN
admet-193	545	3	.	.	PUNCT
admet-193	546	1	[	[	X
admet-193	546	2	32	32	NUM
admet-193	546	3	]	]	PUNCT
admet-193	546	4	g.	g.	PROPN
admet-193	546	5	völgyi	völgyi	PROPN
admet-193	546	6	,	,	PUNCT
admet-193	546	7	a.	a.	NOUN
admet-193	546	8	marosi	marosi	PROPN
admet-193	546	9	,	,	PUNCT
admet-193	546	10	k.	k.	PROPN
admet-193	546	11	takács	takács	PROPN
admet-193	546	12	-	-	PUNCT
admet-193	546	13	novák	novák	PROPN
admet-193	546	14	,	,	PUNCT
admet-193	546	15	a.	a.	PROPN
admet-193	546	16	avdeef	avdeef	PROPN
admet-193	546	17	,	,	PUNCT
admet-193	546	18	admet	admet	PROPN
admet-193	546	19	&	&	CCONJ
admet-193	546	20	dmpk	dmpk	PROPN
admet-193	546	21	1(4	1(4	NUM
admet-193	546	22	)	)	PUNCT
admet-193	546	23	(	(	PUNCT
admet-193	546	24	2013	2013	NUM
admet-193	546	25	)	)	PUNCT
admet-193	546	26	48	48	NUM
admet-193	546	27	-	-	SYM
admet-193	546	28	62	62	NUM
admet-193	546	29	.	.	PUNCT
admet-193	547	1	[	[	X
admet-193	547	2	33	33	NUM
admet-193	547	3	]	]	PUNCT
admet-193	547	4	a.	a.	NOUN
admet-193	547	5	avdeef	avdeef	PROPN
admet-193	547	6	,	,	PUNCT
admet-193	547	7	admet	admet	PROPN
admet-193	547	8	&	&	CCONJ
admet-193	547	9	dmpk	dmpk	PROPN
admet-193	547	10	2(1	2(1	NUM
admet-193	547	11	)	)	PUNCT
admet-193	547	12	(	(	PUNCT
admet-193	547	13	2014	2014	NUM
admet-193	547	14	)	)	PUNCT
admet-193	547	15	33	33	NUM
admet-193	547	16	-	-	SYM
admet-193	547	17	42	42	NUM
admet-193	547	18	.	.	PUNCT
admet-193	548	1	[	[	X
admet-193	548	2	34	34	NUM
admet-193	548	3	]	]	PUNCT
admet-193	548	4	a.	a.	NOUN
admet-193	548	5	avdeef	avdeef	PROPN
admet-193	548	6	,	,	PUNCT
admet-193	548	7	admet	admet	PROPN
admet-193	548	8	&	&	CCONJ
admet-193	548	9	dmpk	dmpk	PROPN
admet-193	548	10	2(1	2(1	NUM
admet-193	548	11	)	)	PUNCT
admet-193	548	12	(	(	PUNCT
admet-193	548	13	2014	2014	NUM
admet-193	548	14	)	)	PUNCT
admet-193	548	15	43	43	NUM
admet-193	548	16	-	-	SYM
admet-193	548	17	55	55	NUM
admet-193	548	18	.	.	PUNCT
admet-193	549	1	[	[	X
admet-193	549	2	35	35	NUM
admet-193	549	3	]	]	PUNCT
admet-193	549	4	m.	m.	PROPN
admet-193	549	5	stuart	stuart	PROPN
admet-193	549	6	,	,	PUNCT
admet-193	549	7	k.	k.	PROPN
admet-193	549	8	box	box	PROPN
admet-193	549	9	,	,	PUNCT
admet-193	549	10	anal	anal	NOUN
admet-193	549	11	.	.	PUNCT
admet-193	549	12	chem	chem	PROPN
admet-193	549	13	.	.	PUNCT
admet-193	550	1	77	77	NUM
admet-193	550	2	(	(	PUNCT
admet-193	550	3	2005	2005	NUM
admet-193	550	4	)	)	PUNCT
admet-193	551	1	983–990	983–990	NUM
admet-193	551	2	.	.	PUNCT
admet-193	552	1	[	[	X
admet-193	552	2	36	36	NUM
admet-193	552	3	]	]	X
admet-193	552	4	c.	c.	NOUN
admet-193	552	5	sköld	sköld	NOUN
admet-193	552	6	,	,	PUNCT
admet-193	552	7	s.	s.	PROPN
admet-193	552	8	winiwarter	winiwarter	PROPN
admet-193	552	9	,	,	PUNCT
admet-193	552	10	j.	j.	PROPN
admet-193	552	11	wernevik	wernevik	PROPN
admet-193	552	12	,	,	PUNCT
admet-193	552	13	f.	f.	PROPN
admet-193	552	14	bergström	bergström	PROPN
admet-193	552	15	,	,	PUNCT
admet-193	552	16	l.	l.	PROPN
admet-193	552	17	engström	engström	PROPN
admet-193	552	18	,	,	PUNCT
admet-193	552	19	r.	r.	PROPN
admet-193	552	20	allen	allen	PROPN
admet-193	552	21	,	,	PUNCT
admet-193	552	22	l.	l.	PROPN
admet-193	552	23	box	box	PROPN
admet-193	552	24	,	,	PUNCT
admet-193	552	25	j.	j.	PROPN
admet-193	552	26	comer	comer	PROPN
admet-193	552	27	,	,	PUNCT
admet-193	552	28	j.	j.	PROPN
admet-193	552	29	mole	mole	PROPN
admet-193	552	30	,	,	PUNCT
admet-193	552	31	a.	a.	PROPN
admet-193	552	32	hallberg	hallberg	PROPN
admet-193	552	33	,	,	PUNCT
admet-193	552	34	h.	h.	PROPN
admet-193	552	35	lennernäs	lennernäs	PROPN
admet-193	552	36	,	,	PUNCT
admet-193	552	37	t.	t.	PROPN
admet-193	552	38	lundstedt	lundstedt	PROPN
admet-193	552	39	,	,	PUNCT
admet-193	552	40	a	a	DET
admet-193	552	41	-	-	PUNCT
admet-193	552	42	l.	l.	NOUN
admet-193	552	43	ungell	ungell	PROPN
admet-193	552	44	,	,	PUNCT
admet-193	552	45	a.	a.	NOUN
admet-193	552	46	karlén	karlén	PROPN
admet-193	552	47	,	,	PUNCT
admet-193	552	48	j.	j.	PROPN
admet-193	552	49	med	med	PROPN
admet-193	552	50	.	.	PROPN
admet-193	552	51	chem	chem	PROPN
admet-193	552	52	.	.	PUNCT
admet-193	553	1	49	49	NUM
admet-193	553	2	(	(	PUNCT
admet-193	553	3	2006	2006	NUM
admet-193	553	4	)	)	PUNCT
admet-193	553	5	6660	6660	NUM
admet-193	553	6	-	-	SYM
admet-193	553	7	6671	6671	NUM
admet-193	553	8	.	.	PUNCT
admet-193	554	1	[	[	X
admet-193	554	2	37	37	NUM
admet-193	554	3	]	]	PUNCT
admet-193	554	4	a.	a.	NOUN
admet-193	554	5	llinàs	llinàs	PROPN
admet-193	554	6	,	,	PUNCT
admet-193	554	7	j.c	j.c	PROPN
admet-193	554	8	.	.	PROPN
admet-193	554	9	burley	burley	PROPN
admet-193	554	10	,	,	PUNCT
admet-193	554	11	k.j	k.j	PROPN
admet-193	554	12	.	.	PROPN
admet-193	554	13	box	box	PROPN
admet-193	554	14	,	,	PUNCT
admet-193	554	15	r.c	r.c	PROPN
admet-193	554	16	.	.	PROPN
admet-193	554	17	glen	glen	PROPN
admet-193	554	18	,	,	PUNCT
admet-193	554	19	j.m	j.m	PROPN
admet-193	554	20	.	.	PROPN
admet-193	554	21	goodman	goodman	PROPN
admet-193	554	22	,	,	PUNCT
admet-193	554	23	j.	j.	PROPN
admet-193	554	24	med	med	PROPN
admet-193	554	25	.	.	PROPN
admet-193	554	26	chem	chem	PROPN
admet-193	554	27	.	.	PUNCT
admet-193	555	1	50	50	NUM
admet-193	555	2	(	(	PUNCT
admet-193	555	3	2007	2007	NUM
admet-193	555	4	)	)	PUNCT
admet-193	555	5	979	979	NUM
admet-193	555	6	-	-	SYM
admet-193	555	7	983	983	NUM
admet-193	555	8	.	.	PUNCT
admet-193	556	1	[	[	X
admet-193	556	2	38	38	NUM
admet-193	556	3	]	]	X
admet-193	556	4	k.j	k.j	PROPN
admet-193	556	5	.	.	PROPN
admet-193	556	6	box	box	PROPN
admet-193	556	7	,	,	PUNCT
admet-193	556	8	j.e.a	j.e.a	PROPN
admet-193	556	9	.	.	PUNCT
admet-193	556	10	comer	comer	PROPN
admet-193	556	11	,	,	PUNCT
admet-193	556	12	curr	curr	PROPN
admet-193	556	13	.	.	PROPN
admet-193	556	14	drug	drug	PROPN
admet-193	556	15	metab	metab	NOUN
admet-193	556	16	.	.	PUNCT
admet-193	557	1	9	9	NUM
admet-193	557	2	(	(	PUNCT
admet-193	557	3	2008	2008	NUM
admet-193	557	4	)	)	PUNCT
admet-193	557	5	869	869	NUM
admet-193	557	6	-	-	SYM
admet-193	557	7	878	878	NUM
admet-193	557	8	.	.	PUNCT
admet-193	558	1	[	[	X
admet-193	558	2	39	39	NUM
admet-193	558	3	]	]	SYM
admet-193	558	4	l.y.s	l.y.s	PROPN
admet-193	558	5	.	.	PUNCT
admet-193	558	6	narasimham	narasimham	PROPN
admet-193	558	7	,	,	PUNCT
admet-193	558	8	v.d	v.d	PROPN
admet-193	558	9	.	.	PROPN
admet-193	558	10	barhate	barhate	PROPN
admet-193	558	11	,	,	PUNCT
admet-193	558	12	j.	j.	PROPN
admet-193	558	13	pharmacy	pharmacy	PROPN
admet-193	558	14	res	re	NOUN
admet-193	558	15	.	.	PUNCT
admet-193	559	1	4(2	4(2	NUM
admet-193	559	2	)	)	PUNCT
admet-193	560	1	(	(	PUNCT
admet-193	560	2	2011	2011	NUM
admet-193	560	3	)	)	PUNCT
admet-193	560	4	532	532	NUM
admet-193	560	5	-	-	SYM
admet-193	560	6	536	536	NUM
admet-193	560	7	.	.	PUNCT
admet-193	561	1	[	[	X
admet-193	561	2	40	40	NUM
admet-193	561	3	]	]	PUNCT
admet-193	561	4	y.-l	y.-l	NOUN
admet-193	561	5	.	.	PUNCT
admet-193	562	1	hsieh	hsieh	PROPN
admet-193	562	2	,	,	PUNCT
admet-193	562	3	g.a	g.a	PROPN
admet-193	562	4	.	.	PROPN
admet-193	562	5	ilevbare	ilevbare	PROPN
admet-193	562	6	,	,	PUNCT
admet-193	562	7	b.	b.	PROPN
admet-193	562	8	van	van	PROPN
admet-193	562	9	eerdenbrugh	eerdenbrugh	PROPN
admet-193	562	10	,	,	PUNCT
admet-193	562	11	k.j	k.j	PROPN
admet-193	562	12	.	.	PROPN
admet-193	562	13	box	box	PROPN
admet-193	562	14	,	,	PUNCT
admet-193	562	15	m.v	m.v	PROPN
admet-193	562	16	.	.	PROPN
admet-193	562	17	sanchez	sanchez	PROPN
admet-193	562	18	-	-	PUNCT
admet-193	562	19	felix	felix	PROPN
admet-193	562	20	,	,	PUNCT
admet-193	562	21	l.s	l.s	PROPN
admet-193	562	22	.	.	PROPN
admet-193	562	23	taylor	taylor	PROPN
admet-193	562	24	,	,	PUNCT
admet-193	562	25	pharm	pharm	PROPN
admet-193	562	26	.	.	PUNCT
admet-193	563	1	res	re	NOUN
admet-193	563	2	.	.	PROPN
admet-193	564	1	29	29	NUM
admet-193	564	2	(	(	PUNCT
admet-193	564	3	2012	2012	NUM
admet-193	564	4	)	)	PUNCT
admet-193	564	5	2738	2738	NUM
admet-193	564	6	-	-	SYM
admet-193	564	7	2753	2753	NUM
admet-193	564	8	.	.	PUNCT
admet-193	565	1	[	[	X
admet-193	565	2	41	41	NUM
admet-193	565	3	]	]	PUNCT
admet-193	565	4	j.	j.	PROPN
admet-193	565	5	comer	comer	PROPN
admet-193	565	6	,	,	PUNCT
admet-193	565	7	s.	s.	PROPN
admet-193	565	8	judge	judge	PROPN
admet-193	565	9	,	,	PUNCT
admet-193	565	10	d.	d.	PROPN
admet-193	565	11	matthews	matthews	PROPN
admet-193	565	12	,	,	PUNCT
admet-193	565	13	l.	l.	PROPN
admet-193	565	14	towes	towes	PROPN
admet-193	565	15	,	,	PUNCT
admet-193	565	16	b.	b.	PROPN
admet-193	565	17	falcone	falcone	PROPN
admet-193	565	18	,	,	PUNCT
admet-193	565	19	j.	j.	PROPN
admet-193	565	20	goodman	goodman	PROPN
admet-193	565	21	,	,	PUNCT
admet-193	565	22	j.	j.	PROPN
admet-193	565	23	dearden	dearden	PROPN
admet-193	565	24	,	,	PUNCT
admet-193	565	25	admet	admet	PROPN
admet-193	565	26	&	&	CCONJ
admet-193	565	27	dmpk	dmpk	PROPN
admet-193	565	28	2(1	2(1	NUM
admet-193	565	29	)	)	PUNCT
admet-193	565	30	(	(	PUNCT
admet-193	565	31	2014	2014	NUM
admet-193	565	32	)	)	PUNCT
admet-193	565	33	18	18	NUM
admet-193	565	34	-	-	SYM
admet-193	565	35	32	32	NUM
admet-193	565	36	.	.	PUNCT
admet-193	566	1	[	[	X
admet-193	566	2	42	42	NUM
admet-193	566	3	]	]	X
admet-193	566	4	d.	d.	PROPN
admet-193	566	5	schönherr	schönherr	PROPN
admet-193	566	6	,	,	PUNCT
admet-193	566	7	u.	u.	PROPN
admet-193	566	8	wollatz	wollatz	PROPN
admet-193	566	9	,	,	PUNCT
admet-193	566	10	d.	d.	PROPN
admet-193	566	11	haznar	haznar	PROPN
admet-193	566	12	-	-	PUNCT
admet-193	566	13	garbacz	garbacz	NOUN
admet-193	566	14	,	,	PUNCT
admet-193	566	15	u.	u.	PROPN
admet-193	566	16	hanke	hanke	PROPN
admet-193	566	17	,	,	PUNCT
admet-193	566	18	k.j	k.j	PROPN
admet-193	566	19	.	.	PROPN
admet-193	566	20	box	box	PROPN
admet-193	566	21	,	,	PUNCT
admet-193	566	22	r.	r.	PROPN
admet-193	566	23	taylor	taylor	PROPN
admet-193	566	24	,	,	PUNCT
admet-193	566	25	r.	r.	PROPN
admet-193	566	26	ruiz	ruiz	PROPN
admet-193	566	27	,	,	PUNCT
admet-193	566	28	s.	s.	PROPN
admet-193	566	29	beato	beato	PROPN
admet-193	566	30	,	,	PUNCT
admet-193	566	31	d.	d.	PROPN
admet-193	566	32	http://www.srcinc.com/what-we-do/environmental/scientific-databases.html	http://www.srcinc.com/what-we-do/environmental/scientific-databases.html	PROPN
admet-193	566	33	admet	admet	PROPN
admet-193	566	34	&	&	CCONJ
admet-193	566	35	dmpk	dmpk	PROPN
admet-193	566	36	3(2	3(2	NUM
admet-193	566	37	)	)	PUNCT
admet-193	566	38	(	(	PUNCT
admet-193	566	39	2015	2015	NUM
admet-193	566	40	)	)	PUNCT
admet-193	566	41	84	84	NUM
admet-193	566	42	-	-	SYM
admet-193	566	43	109	109	NUM
admet-193	566	44	equilibrium	equilibrium	NOUN
admet-193	566	45	solubility	solubility	NOUN
admet-193	566	46	measurements	measurement	NOUN
admet-193	566	47	improvements	improvement	NOUN
admet-193	566	48	doi	doi	NOUN
admet-193	566	49	:	:	PUNCT
admet-193	566	50	10.5599	10.5599	NUM
admet-193	566	51	/	/	SYM
admet-193	566	52	admet.3.2.193	admet.3.2.193	ADJ
admet-193	566	53	103	103	NUM
admet-193	566	54	becker	becker	NOUN
admet-193	566	55	,	,	PUNCT
admet-193	566	56	w.	w.	PROPN
admet-193	566	57	weitschies	weitschie	NOUN
admet-193	566	58	,	,	PUNCT
admet-193	566	59	eur	eur	PROPN
admet-193	566	60	.	.	PUNCT
admet-193	566	61	j.	j.	PROPN
admet-193	566	62	pharm	pharm	PROPN
admet-193	566	63	.	.	PUNCT
admet-193	567	1	biopharm	biopharm	PROPN
admet-193	567	2	.	.	PUNCT
admet-193	568	1	92	92	NUM
admet-193	568	2	(	(	PUNCT
admet-193	568	3	2015	2015	NUM
admet-193	568	4	)	)	PUNCT
admet-193	568	5	155–170	155–170	NUM
admet-193	568	6	.	.	PUNCT
admet-193	569	1	[	[	X
admet-193	569	2	43	43	NUM
admet-193	569	3	]	]	PUNCT
admet-193	569	4	a.	a.	NOUN
admet-193	569	5	avdeef	avdeef	PROPN
admet-193	569	6	,	,	PUNCT
admet-193	569	7	pharm	pharm	PROPN
admet-193	569	8	.	.	PUNCT
admet-193	570	1	pharmacol	pharmacol	PROPN
admet-193	570	2	.	.	PUNCT
admet-193	571	1	commun	commun	PROPN
admet-193	571	2	.	.	PUNCT
admet-193	572	1	4	4	NUM
admet-193	572	2	(	(	PUNCT
admet-193	572	3	1998	1998	NUM
admet-193	572	4	)	)	PUNCT
admet-193	572	5	165	165	NUM
admet-193	572	6	-	-	SYM
admet-193	572	7	178	178	NUM
admet-193	572	8	.	.	PUNCT
admet-193	573	1	[	[	X
admet-193	573	2	44	44	NUM
admet-193	573	3	]	]	PUNCT
admet-193	573	4	a.	a.	NOUN
admet-193	573	5	avdeef	avdeef	PROPN
admet-193	573	6	,	,	PUNCT
admet-193	573	7	c.m	c.m	PROPN
admet-193	573	8	.	.	PROPN
admet-193	573	9	berger	berger	PROPN
admet-193	573	10	,	,	PUNCT
admet-193	573	11	c.	c.	PROPN
admet-193	573	12	brownell	brownell	PROPN
admet-193	573	13	,	,	PUNCT
admet-193	573	14	pharm	pharm	PROPN
admet-193	573	15	.	.	PUNCT
admet-193	574	1	res	re	NOUN
admet-193	574	2	.	.	PROPN
admet-193	575	1	17	17	NUM
admet-193	575	2	(	(	PUNCT
admet-193	575	3	2000	2000	NUM
admet-193	575	4	)	)	PUNCT
admet-193	575	5	85	85	NUM
admet-193	575	6	-	-	SYM
admet-193	575	7	89	89	NUM
admet-193	575	8	.	.	PUNCT
admet-193	576	1	[	[	X
admet-193	576	2	45	45	NUM
admet-193	576	3	]	]	PUNCT
admet-193	576	4	a.	a.	NOUN
admet-193	576	5	avdeef	avdeef	PROPN
admet-193	576	6	,	,	PUNCT
admet-193	576	7	c.m	c.m	PROPN
admet-193	576	8	.	.	PROPN
admet-193	576	9	berger	berger	PROPN
admet-193	576	10	,	,	PUNCT
admet-193	576	11	eur	eur	PROPN
admet-193	576	12	.	.	PUNCT
admet-193	577	1	j.	j.	PROPN
admet-193	577	2	pharm	pharm	PROPN
admet-193	577	3	.	.	PUNCT
admet-193	578	1	sci	sci	PROPN
admet-193	578	2	.	.	PROPN
admet-193	579	1	14	14	NUM
admet-193	579	2	(	(	PUNCT
admet-193	579	3	2001	2001	NUM
admet-193	579	4	)	)	PUNCT
admet-193	579	5	281	281	NUM
admet-193	579	6	-	-	SYM
admet-193	579	7	291	291	NUM
admet-193	579	8	.	.	PUNCT
admet-193	580	1	[	[	X
admet-193	580	2	46	46	NUM
admet-193	580	3	]	]	PUNCT
admet-193	580	4	a.	a.	NOUN
admet-193	580	5	avdeef	avdeef	PROPN
admet-193	580	6	,	,	PUNCT
admet-193	580	7	curr	curr	PROPN
admet-193	580	8	.	.	PUNCT
admet-193	581	1	topics	topic	NOUN
admet-193	581	2	med	me	VERB
admet-193	581	3	.	.	PUNCT
admet-193	581	4	chem	chem	PROPN
admet-193	581	5	.	.	PUNCT
admet-193	582	1	1	1	NUM
admet-193	582	2	(	(	PUNCT
admet-193	582	3	2001	2001	NUM
admet-193	582	4	)	)	PUNCT
admet-193	582	5	277	277	NUM
admet-193	582	6	-	-	SYM
admet-193	582	7	351	351	NUM
admet-193	582	8	.	.	PUNCT
admet-193	583	1	[	[	X
admet-193	583	2	47	47	NUM
admet-193	583	3	]	]	X
admet-193	583	4	b.	b.	PROPN
admet-193	583	5	faller	faller	PROPN
admet-193	583	6	,	,	PUNCT
admet-193	583	7	f.	f.	PROPN
admet-193	583	8	wohnsland	wohnsland	PROPN
admet-193	583	9	,	,	PUNCT
admet-193	583	10	physicochemical	physicochemical	ADJ
admet-193	583	11	parameters	parameter	NOUN
admet-193	583	12	as	as	ADP
admet-193	583	13	tools	tool	NOUN
admet-193	583	14	in	in	ADP
admet-193	583	15	drug	drug	NOUN
admet-193	583	16	discovery	discovery	NOUN
admet-193	583	17	and	and	CCONJ
admet-193	583	18	lead	lead	VERB
admet-193	583	19	optimization	optimization	NOUN
admet-193	583	20	.	.	PUNCT
admet-193	584	1	in	in	ADP
admet-193	584	2	:	:	PUNCT
admet-193	584	3	b.	b.	PROPN
admet-193	584	4	testa	testa	PROPN
admet-193	584	5	,	,	PUNCT
admet-193	584	6	h.	h.	PROPN
admet-193	584	7	van	van	PROPN
admet-193	584	8	de	de	PROPN
admet-193	584	9	waterbeemd	waterbeemd	PROPN
admet-193	584	10	,	,	PUNCT
admet-193	584	11	g.	g.	PROPN
admet-193	584	12	folkers	folkers	PROPN
admet-193	584	13	,	,	PUNCT
admet-193	584	14	r.	r.	PROPN
admet-193	584	15	guy	guy	PROPN
admet-193	584	16	,	,	PUNCT
admet-193	584	17	r.	r.	PROPN
admet-193	584	18	(	(	PUNCT
admet-193	584	19	eds	eds	PROPN
admet-193	584	20	.	.	PUNCT
admet-193	584	21	)	)	PUNCT
admet-193	584	22	.	.	PUNCT
admet-193	585	1	pharmacokinetic	pharmacokinetic	ADJ
admet-193	585	2	optimization	optimization	NOUN
admet-193	585	3	in	in	ADP
admet-193	585	4	drug	drug	NOUN
admet-193	585	5	research	research	NOUN
admet-193	585	6	.	.	PUNCT
admet-193	586	1	verlag	verlag	PROPN
admet-193	586	2	helvetica	helvetica	PROPN
admet-193	586	3	chimica	chimica	PROPN
admet-193	586	4	acta	acta	PROPN
admet-193	586	5	:	:	PUNCT
admet-193	586	6	zürich	zürich	NOUN
admet-193	586	7	and	and	CCONJ
admet-193	586	8	wiley	wiley	PROPN
admet-193	586	9	vch	vch	PROPN
admet-193	586	10	:	:	PUNCT
admet-193	586	11	weinheim	weinheim	PROPN
admet-193	586	12	,	,	PUNCT
admet-193	586	13	pp	pp	ADP
admet-193	586	14	.	.	PUNCT
admet-193	587	1	257	257	NUM
admet-193	587	2	-	-	SYM
admet-193	587	3	274	274	NUM
admet-193	587	4	(	(	PUNCT
admet-193	587	5	2001	2001	NUM
admet-193	587	6	)	)	PUNCT
admet-193	587	7	.	.	PUNCT
admet-193	588	1	[	[	X
admet-193	588	2	48	48	NUM
admet-193	588	3	]	]	PUNCT
admet-193	588	4	c.a.s	c.a.s	PROPN
admet-193	588	5	.	.	PROPN
admet-193	588	6	bergström	bergström	NOUN
admet-193	588	7	,	,	PUNCT
admet-193	588	8	m.	m.	NOUN
admet-193	588	9	strafford	strafford	PROPN
admet-193	588	10	,	,	PUNCT
admet-193	588	11	l.	l.	PROPN
admet-193	588	12	lazarova	lazarova	PROPN
admet-193	588	13	,	,	PUNCT
admet-193	588	14	a.	a.	NOUN
admet-193	588	15	avdeef	avdeef	PROPN
admet-193	588	16	,	,	PUNCT
admet-193	588	17	k.	k.	PROPN
admet-193	588	18	luthman	luthman	PROPN
admet-193	588	19	,	,	PUNCT
admet-193	588	20	p.	p.	PROPN
admet-193	588	21	artursson	artursson	PROPN
admet-193	588	22	,	,	PUNCT
admet-193	588	23	j.	j.	PROPN
admet-193	588	24	med	med	PROPN
admet-193	588	25	.	.	PROPN
admet-193	588	26	chem	chem	PROPN
admet-193	588	27	.	.	PUNCT
admet-193	589	1	46	46	NUM
admet-193	589	2	(	(	PUNCT
admet-193	589	3	2003	2003	NUM
admet-193	589	4	)	)	PUNCT
admet-193	589	5	558	558	NUM
admet-193	589	6	-	-	SYM
admet-193	589	7	570	570	NUM
admet-193	589	8	.	.	PUNCT
admet-193	590	1	[	[	X
admet-193	590	2	49	49	NUM
admet-193	590	3	]	]	X
admet-193	590	4	a.f	a.f	PROPN
admet-193	590	5	.	.	PROPN
admet-193	590	6	fioritto	fioritto	PROPN
admet-193	590	7	,	,	PUNCT
admet-193	590	8	s.n	s.n	PROPN
admet-193	590	9	.	.	PROPN
admet-193	590	10	bhattachar	bhattachar	PROPN
admet-193	590	11	,	,	PUNCT
admet-193	590	12	j.a	j.a	PROPN
admet-193	590	13	.	.	PROPN
admet-193	590	14	wesley	wesley	PROPN
admet-193	590	15	,	,	PUNCT
admet-193	590	16	int	int	PROPN
admet-193	590	17	.	.	PUNCT
admet-193	591	1	j.	j.	PROPN
admet-193	591	2	pharm	pharm	PROPN
admet-193	591	3	.	.	PUNCT
admet-193	592	1	330	330	NUM
admet-193	592	2	(	(	PUNCT
admet-193	592	3	2007	2007	NUM
admet-193	592	4	)	)	PUNCT
admet-193	592	5	105	105	NUM
admet-193	592	6	-	-	SYM
admet-193	592	7	113	113	NUM
admet-193	592	8	.	.	PUNCT
admet-193	593	1	[	[	X
admet-193	593	2	50	50	NUM
admet-193	593	3	]	]	X
admet-193	593	4	g.	g.	PROPN
admet-193	593	5	ottaviani	ottaviani	PROPN
admet-193	593	6	,	,	PUNCT
admet-193	593	7	d.j	d.j	PROPN
admet-193	593	8	.	.	PROPN
admet-193	593	9	gosling	gosling	PROPN
admet-193	593	10	,	,	PUNCT
admet-193	593	11	c.	c.	PROPN
admet-193	593	12	patissier	patissier	PROPN
admet-193	593	13	,	,	PUNCT
admet-193	593	14	s.	s.	PROPN
admet-193	593	15	rodde	rodde	PROPN
admet-193	593	16	,	,	PUNCT
admet-193	593	17	l.	l.	PROPN
admet-193	593	18	zhou	zhou	PROPN
admet-193	593	19	,	,	PUNCT
admet-193	593	20	b.	b.	PROPN
admet-193	593	21	faller	faller	PROPN
admet-193	593	22	,	,	PUNCT
admet-193	593	23	eur	eur	PROPN
admet-193	593	24	.	.	PUNCT
admet-193	594	1	j.	j.	PROPN
admet-193	594	2	pharm	pharm	PROPN
admet-193	594	3	.	.	PUNCT
admet-193	595	1	sci	sci	PROPN
admet-193	595	2	.	.	PROPN
admet-193	596	1	41	41	NUM
admet-193	596	2	(	(	PUNCT
admet-193	596	3	2010	2010	NUM
admet-193	596	4	)	)	PUNCT
admet-193	596	5	452457	452457	NUM
admet-193	596	6	.	.	PUNCT
admet-193	597	1	[	[	X
admet-193	597	2	51	51	NUM
admet-193	597	3	]	]	X
admet-193	597	4	y.	y.	NOUN
admet-193	597	5	surakitbanharn	surakitbanharn	PROPN
admet-193	597	6	,	,	PUNCT
admet-193	597	7	r.	r.	PROPN
admet-193	597	8	mccandless	mccandless	PROPN
admet-193	597	9	,	,	PUNCT
admet-193	597	10	j.p	j.p	PROPN
admet-193	597	11	.	.	PROPN
admet-193	597	12	krzyzaniak	krzyzaniak	PROPN
admet-193	597	13	,	,	PUNCT
admet-193	597	14	r	r	NOUN
admet-193	597	15	-	-	PUNCT
admet-193	597	16	m.	m.	NOUN
admet-193	597	17	dannenfelser	dannenfelser	NOUN
admet-193	597	18	,	,	PUNCT
admet-193	597	19	s.h	s.h	PROPN
admet-193	597	20	.	.	PROPN
admet-193	597	21	yalkowsky	yalkowsky	PROPN
admet-193	597	22	,	,	PUNCT
admet-193	597	23	j.	j.	PROPN
admet-193	597	24	pharm	pharm	PROPN
admet-193	597	25	.	.	PUNCT
admet-193	598	1	sci	sci	PROPN
admet-193	598	2	.	.	PROPN
admet-193	599	1	84	84	NUM
admet-193	599	2	(	(	PUNCT
admet-193	599	3	1995	1995	NUM
admet-193	599	4	)	)	PUNCT
admet-193	599	5	720	720	NUM
admet-193	599	6	-	-	SYM
admet-193	599	7	723	723	NUM
admet-193	599	8	.	.	PUNCT
admet-193	600	1	[	[	X
admet-193	600	2	52	52	NUM
admet-193	600	3	]	]	PUNCT
admet-193	600	4	a.	a.	NOUN
admet-193	600	5	avdeef	avdeef	PROPN
admet-193	600	6	,	,	PUNCT
admet-193	600	7	absorption	absorption	NOUN
admet-193	600	8	and	and	CCONJ
admet-193	600	9	drug	drug	NOUN
admet-193	600	10	development	development	PROPN
admet-193	600	11	second	second	PROPN
admet-193	600	12	edition	edition	PROPN
admet-193	600	13	.	.	PUNCT
admet-193	601	1	wiley	wiley	PROPN
admet-193	601	2	-	-	PUNCT
admet-193	601	3	interscience	interscience	PROPN
admet-193	601	4	:	:	PUNCT
admet-193	601	5	new	new	PROPN
admet-193	601	6	york	york	PROPN
admet-193	601	7	.	.	PUNCT
admet-193	601	8	2012	2012	NUM
admet-193	601	9	.	.	PUNCT
admet-193	602	1	[	[	X
admet-193	602	2	53	53	NUM
admet-193	602	3	]	]	PUNCT
admet-193	602	4	e.	e.	PROPN
admet-193	602	5	shoghi	shoghi	PROPN
admet-193	602	6	,	,	PUNCT
admet-193	602	7	e.	e.	PROPN
admet-193	602	8	fuguet	fuguet	PROPN
admet-193	602	9	,	,	PUNCT
admet-193	602	10	e.	e.	PROPN
admet-193	602	11	bosch	bosch	PROPN
admet-193	602	12	,	,	PUNCT
admet-193	602	13	c.	c.	PROPN
admet-193	602	14	rafols	rafols	PROPN
admet-193	602	15	,	,	PUNCT
admet-193	602	16	eur	eur	PROPN
admet-193	602	17	.	.	PUNCT
admet-193	603	1	j.	j.	PROPN
admet-193	603	2	pharm	pharm	PROPN
admet-193	603	3	.	.	PUNCT
admet-193	604	1	sci	sci	PROPN
admet-193	604	2	.	.	PROPN
admet-193	605	1	48	48	NUM
admet-193	605	2	(	(	PUNCT
admet-193	605	3	2012	2012	NUM
admet-193	605	4	)	)	PUNCT
admet-193	605	5	290	290	NUM
admet-193	605	6	-	-	SYM
admet-193	605	7	300	300	NUM
admet-193	605	8	.	.	PUNCT
admet-193	606	1	[	[	X
admet-193	606	2	54	54	NUM
admet-193	606	3	]	]	PUNCT
admet-193	606	4	i.	i.	PROPN
admet-193	606	5	zimmermann	zimmermann	PROPN
admet-193	606	6	,	,	PUNCT
admet-193	606	7	int	int	NOUN
admet-193	606	8	.	.	PUNCT
admet-193	607	1	j.	j.	PROPN
admet-193	607	2	pharm	pharm	PROPN
admet-193	607	3	.	.	PUNCT
admet-193	608	1	31	31	NUM
admet-193	608	2	(	(	PUNCT
admet-193	608	3	1986	1986	NUM
admet-193	608	4	)	)	PUNCT
admet-193	608	5	69	69	NUM
admet-193	608	6	-	-	SYM
admet-193	608	7	74	74	NUM
admet-193	608	8	.	.	PUNCT
admet-193	609	1	[	[	X
admet-193	609	2	55	55	NUM
admet-193	609	3	]	]	PUNCT
admet-193	609	4	a.	a.	NOUN
admet-193	609	5	avdeef	avdeef	PROPN
admet-193	609	6	,	,	PUNCT
admet-193	609	7	j.j	j.j	PROPN
admet-193	609	8	.	.	PROPN
admet-193	609	9	bucher	bucher	PROPN
admet-193	609	10	,	,	PUNCT
admet-193	609	11	anal	anal	PROPN
admet-193	609	12	.	.	PUNCT
admet-193	609	13	chem	chem	PROPN
admet-193	609	14	.	.	PUNCT
admet-193	610	1	50	50	NUM
admet-193	610	2	(	(	PUNCT
admet-193	610	3	1978	1978	NUM
admet-193	610	4	)	)	PUNCT
admet-193	610	5	2137	2137	NUM
admet-193	610	6	-	-	SYM
admet-193	610	7	2142	2142	NUM
admet-193	610	8	.	.	PUNCT
admet-193	611	1	[	[	X
admet-193	611	2	56	56	NUM
admet-193	611	3	]	]	PUNCT
admet-193	611	4	z.	z.	PROPN
admet-193	611	5	wang	wang	PROPN
admet-193	611	6	,	,	PUNCT
admet-193	611	7	l.s	l.s	PROPN
admet-193	611	8	.	.	PROPN
admet-193	611	9	burrell	burrell	PROPN
admet-193	611	10	,	,	PUNCT
admet-193	611	11	w.j	w.j	PROPN
admet-193	611	12	.	.	PROPN
admet-193	611	13	lambert	lambert	PROPN
admet-193	611	14	,	,	PUNCT
admet-193	611	15	j.	j.	PROPN
admet-193	611	16	pharm	pharm	PROPN
admet-193	611	17	.	.	PUNCT
admet-193	612	1	sci	sci	PROPN
admet-193	612	2	.	.	PROPN
admet-193	613	1	91	91	NUM
admet-193	613	2	(	(	PUNCT
admet-193	613	3	2002	2002	NUM
admet-193	613	4	)	)	PUNCT
admet-193	613	5	1445	1445	NUM
admet-193	613	6	-	-	SYM
admet-193	613	7	1455	1455	NUM
admet-193	613	8	.	.	PUNCT
admet-193	614	1	[	[	X
admet-193	614	2	57	57	NUM
admet-193	614	3	]	]	PUNCT
admet-193	614	4	a.	a.	NOUN
admet-193	614	5	avdeef	avdeef	PROPN
admet-193	614	6	,	,	PUNCT
admet-193	614	7	adv	adv	PROPN
admet-193	614	8	.	.	PUNCT
admet-193	614	9	drug	drug	PROPN
admet-193	614	10	deliv	deliv	PROPN
admet-193	614	11	.	.	PUNCT
admet-193	615	1	rev	rev	PROPN
admet-193	615	2	.	.	PROPN
admet-193	615	3	59	59	NUM
admet-193	615	4	(	(	PUNCT
admet-193	615	5	2007	2007	NUM
admet-193	615	6	)	)	PUNCT
admet-193	615	7	568	568	NUM
admet-193	615	8	-	-	SYM
admet-193	615	9	590	590	NUM
admet-193	615	10	[	[	X
admet-193	615	11	58	58	NUM
admet-193	615	12	]	]	SYM
admet-193	615	13	t	t	PROPN
admet-193	615	14	-	-	PUNCT
admet-193	615	15	m.	m.	NOUN
admet-193	615	16	chen	chen	PROPN
admet-193	615	17	,	,	PUNCT
admet-193	615	18	h.	h.	PROPN
admet-193	615	19	shen	shen	PROPN
admet-193	615	20	,	,	PUNCT
admet-193	615	21	c.	c.	PROPN
admet-193	615	22	zhu	zhu	PROPN
admet-193	615	23	,	,	PUNCT
admet-193	615	24	combi	combi	PROPN
admet-193	615	25	.	.	PUNCT
admet-193	616	1	chem	chem	PROPN
admet-193	616	2	.	.	PUNCT
admet-193	617	1	hts	hts	PROPN
admet-193	617	2	5	5	NUM
admet-193	617	3	(	(	PUNCT
admet-193	617	4	2002	2002	NUM
admet-193	617	5	)	)	PUNCT
admet-193	617	6	575	575	NUM
admet-193	617	7	-	-	SYM
admet-193	617	8	581	581	NUM
admet-193	617	9	.	.	PUNCT
admet-193	618	1	[	[	X
admet-193	618	2	59	59	NUM
admet-193	618	3	]	]	X
admet-193	618	4	s.l	s.l	PROPN
admet-193	618	5	.	.	PROPN
admet-193	618	6	mcgovern	mcgovern	PROPN
admet-193	618	7	,	,	PUNCT
admet-193	618	8	e.	e.	PROPN
admet-193	618	9	caselli	caselli	PROPN
admet-193	618	10	,	,	PUNCT
admet-193	618	11	n.	n.	PROPN
admet-193	618	12	grigorieff	grigorieff	PROPN
admet-193	618	13	,	,	PUNCT
admet-193	618	14	b.k	b.k	PROPN
admet-193	618	15	.	.	PROPN
admet-193	618	16	shoichet	shoichet	PROPN
admet-193	618	17	,	,	PUNCT
admet-193	618	18	j.	j.	PROPN
admet-193	618	19	med	med	PROPN
admet-193	618	20	.	.	PROPN
admet-193	618	21	chem	chem	PROPN
admet-193	618	22	.	.	PUNCT
admet-193	619	1	45	45	NUM
admet-193	619	2	(	(	PUNCT
admet-193	619	3	2002	2002	NUM
admet-193	619	4	)	)	PUNCT
admet-193	619	5	1712	1712	NUM
admet-193	619	6	-	-	SYM
admet-193	619	7	1722	1722	NUM
admet-193	619	8	.	.	PUNCT
admet-193	620	1	[	[	X
admet-193	620	2	60	60	NUM
admet-193	620	3	]	]	PUNCT
admet-193	620	4	t.	t.	PROPN
admet-193	620	5	loftsson	loftsson	PROPN
admet-193	620	6	,	,	PUNCT
admet-193	620	7	d.	d.	PROPN
admet-193	620	8	hreinsdóttir	hreinsdóttir	PROPN
admet-193	620	9	,	,	PUNCT
admet-193	620	10	m.	m.	NOUN
admet-193	620	11	másson	másson	PROPN
admet-193	620	12	,	,	PUNCT
admet-193	620	13	int	int	NOUN
admet-193	620	14	.	.	PUNCT
admet-193	621	1	j.	j.	PROPN
admet-193	621	2	pharm	pharm	PROPN
admet-193	621	3	.	.	PUNCT
admet-193	622	1	302	302	NUM
admet-193	622	2	(	(	PUNCT
admet-193	622	3	2005	2005	NUM
admet-193	622	4	)	)	PUNCT
admet-193	622	5	18–28	18–28	NUM
admet-193	622	6	.	.	PUNCT
admet-193	623	1	[	[	X
admet-193	623	2	61	61	NUM
admet-193	623	3	]	]	PUNCT
admet-193	623	4	s.	s.	PROPN
admet-193	623	5	venkatesh	venkatesh	PROPN
admet-193	623	6	,	,	PUNCT
admet-193	623	7	j.	j.	PROPN
admet-193	623	8	li	li	PROPN
admet-193	623	9	,	,	PUNCT
admet-193	623	10	y.	y.	PROPN
admet-193	623	11	xu	xu	PROPN
admet-193	623	12	,	,	PUNCT
admet-193	623	13	r.	r.	PROPN
admet-193	623	14	vishnuvajjala	vishnuvajjala	PROPN
admet-193	623	15	,	,	PUNCT
admet-193	623	16	pharm	pharm	NOUN
admet-193	623	17	.	.	PUNCT
admet-193	624	1	res	re	NOUN
admet-193	624	2	.	.	PROPN
admet-193	624	3	13	13	NUM
admet-193	624	4	(	(	PUNCT
admet-193	624	5	1996	1996	NUM
admet-193	624	6	)	)	PUNCT
admet-193	624	7	1453	1453	NUM
admet-193	624	8	-	-	SYM
admet-193	624	9	1459	1459	NUM
admet-193	624	10	.	.	PUNCT
admet-193	625	1	[	[	X
admet-193	625	2	62	62	NUM
admet-193	625	3	]	]	X
admet-193	625	4	y.	y.	NOUN
admet-193	625	5	he	he	PRON
admet-193	625	6	,	,	PUNCT
admet-193	625	7	s.e	s.e	PROPN
admet-193	625	8	.	.	PROPN
admet-193	625	9	tabibi	tabibi	NOUN
admet-193	625	10	,	,	PUNCT
admet-193	625	11	s.h	s.h	PROPN
admet-193	625	12	.	.	NOUN
admet-193	625	13	yalkowsky	yalkowsky	PROPN
admet-193	625	14	,	,	PUNCT
admet-193	625	15	j.	j.	PROPN
admet-193	625	16	pharm	pharm	PROPN
admet-193	625	17	.	.	PUNCT
admet-193	626	1	sci	sci	PROPN
admet-193	626	2	.	.	PROPN
admet-193	627	1	95	95	NUM
admet-193	627	2	(	(	PUNCT
admet-193	627	3	2006	2006	NUM
admet-193	627	4	)	)	PUNCT
admet-193	627	5	97	97	NUM
admet-193	627	6	-	-	SYM
admet-193	627	7	107	107	NUM
admet-193	627	8	.	.	PUNCT
admet-193	628	1	[	[	X
admet-193	628	2	63	63	NUM
admet-193	628	3	]	]	PUNCT
admet-193	628	4	a.	a.	NOUN
admet-193	628	5	fini	fini	PROPN
admet-193	628	6	,	,	PUNCT
admet-193	628	7	g.	g.	PROPN
admet-193	628	8	fazio	fazio	PROPN
admet-193	628	9	,	,	PUNCT
admet-193	628	10	g.	g.	PROPN
admet-193	628	11	feroci	feroci	PROPN
admet-193	628	12	,	,	PUNCT
admet-193	628	13	int	int	PROPN
admet-193	628	14	.	.	PUNCT
admet-193	629	1	j.	j.	PROPN
admet-193	629	2	pharm	pharm	PROPN
admet-193	629	3	.	.	PUNCT
admet-193	630	1	126	126	NUM
admet-193	630	2	(	(	PUNCT
admet-193	630	3	1995	1995	NUM
admet-193	630	4	)	)	PUNCT
admet-193	630	5	95	95	NUM
admet-193	630	6	-	-	SYM
admet-193	630	7	102	102	NUM
admet-193	630	8	.	.	PUNCT
admet-193	631	1	[	[	X
admet-193	631	2	64	64	NUM
admet-193	631	3	]	]	PUNCT
admet-193	631	4	m.	m.	NOUN
admet-193	631	5	pudipeddi	pudipeddi	NOUN
admet-193	631	6	,	,	PUNCT
admet-193	631	7	a.t.m	a.t.m	PROPN
admet-193	631	8	.	.	PUNCT
admet-193	631	9	serajuddin	serajuddin	PROPN
admet-193	631	10	,	,	PUNCT
admet-193	631	11	j.	j.	PROPN
admet-193	631	12	pharm	pharm	PROPN
admet-193	631	13	.	.	PUNCT
admet-193	632	1	sci	sci	PROPN
admet-193	632	2	.	.	PROPN
admet-193	633	1	94	94	NUM
admet-193	633	2	(	(	PUNCT
admet-193	633	3	2005	2005	NUM
admet-193	633	4	)	)	PUNCT
admet-193	633	5	929	929	NUM
admet-193	633	6	-	-	SYM
admet-193	633	7	939	939	NUM
admet-193	633	8	.	.	PUNCT
admet-193	634	1	[	[	X
admet-193	634	2	65	65	NUM
admet-193	634	3	]	]	X
admet-193	634	4	b.d	b.d	PROPN
admet-193	634	5	.	.	PROPN
admet-193	634	6	anderson	anderson	PROPN
admet-193	634	7	,	,	PUNCT
admet-193	634	8	k.p	k.p	PROPN
admet-193	634	9	.	.	PROPN
admet-193	634	10	flora	flora	PROPN
admet-193	634	11	,	,	PUNCT
admet-193	634	12	preparation	preparation	NOUN
admet-193	634	13	of	of	ADP
admet-193	634	14	water	water	NOUN
admet-193	634	15	-	-	PUNCT
admet-193	634	16	soluble	soluble	ADJ
admet-193	634	17	compounds	compound	NOUN
admet-193	634	18	through	through	ADP
admet-193	634	19	salt	salt	NOUN
admet-193	634	20	formation	formation	NOUN
admet-193	634	21	.	.	PUNCT
admet-193	635	1	in	in	ADP
admet-193	635	2	:	:	PUNCT
admet-193	635	3	c.g	c.g	PROPN
admet-193	635	4	.	.	PROPN
admet-193	635	5	wermuth	wermuth	PROPN
admet-193	635	6	,	,	PUNCT
admet-193	635	7	(	(	PUNCT
admet-193	635	8	ed	ed	NOUN
admet-193	635	9	.	.	PUNCT
admet-193	635	10	)	)	PUNCT
admet-193	635	11	.	.	PUNCT
admet-193	636	1	the	the	DET
admet-193	636	2	practice	practice	NOUN
admet-193	636	3	of	of	ADP
admet-193	636	4	medicinal	medicinal	ADJ
admet-193	636	5	chemistry	chemistry	NOUN
admet-193	636	6	.	.	PUNCT
admet-193	637	1	academic	academic	ADJ
admet-193	637	2	press	press	PROPN
admet-193	637	3	,	,	PUNCT
admet-193	637	4	london	london	PROPN
admet-193	637	5	,	,	PUNCT
admet-193	637	6	pp	pp	ADP
admet-193	637	7	.	.	PUNCT
admet-193	638	1	739	739	NUM
admet-193	638	2	-	-	SYM
admet-193	638	3	754	754	NUM
admet-193	638	4	(	(	PUNCT
admet-193	638	5	1996	1996	NUM
admet-193	638	6	)	)	PUNCT
admet-193	638	7	.	.	PUNCT
admet-193	639	1	[	[	X
admet-193	639	2	66	66	NUM
admet-193	639	3	]	]	PUNCT
admet-193	639	4	h.	h.	PROPN
admet-193	639	5	kishi	kishi	PROPN
admet-193	639	6	,	,	PUNCT
admet-193	639	7	y.	y.	PROPN
admet-193	639	8	hashimoto	hashimoto	PROPN
admet-193	639	9	,	,	PUNCT
admet-193	639	10	chemosphere	chemosphere	ADV
admet-193	639	11	18	18	NUM
admet-193	639	12	(	(	PUNCT
admet-193	639	13	1989	1989	NUM
admet-193	639	14	)	)	PUNCT
admet-193	639	15	1749	1749	NUM
admet-193	639	16	-	-	SYM
admet-193	639	17	1759	1759	NUM
admet-193	639	18	.	.	PUNCT
admet-193	640	1	[	[	X
admet-193	640	2	67	67	NUM
admet-193	640	3	]	]	X
admet-193	640	4	a.r	a.r	PROPN
admet-193	640	5	.	.	PROPN
admet-193	640	6	katritzky	katritzky	PROPN
admet-193	640	7	,	,	PUNCT
admet-193	640	8	y.	y.	PROPN
admet-193	640	9	wang	wang	PROPN
admet-193	640	10	,	,	PUNCT
admet-193	640	11	s.	s.	PROPN
admet-193	640	12	sild	sild	PROPN
admet-193	640	13	,	,	PUNCT
admet-193	640	14	t.	t.	PROPN
admet-193	640	15	tamm	tamm	PROPN
admet-193	640	16	,	,	PUNCT
admet-193	640	17	m.	m.	PROPN
admet-193	640	18	karelson	karelson	PROPN
admet-193	640	19	,	,	PUNCT
admet-193	640	20	j.	j.	PROPN
admet-193	640	21	chem	chem	PROPN
admet-193	640	22	.	.	PUNCT
admet-193	641	1	inf	inf	PROPN
admet-193	641	2	.	.	PUNCT
admet-193	641	3	comput	comput	PROPN
admet-193	641	4	.	.	PUNCT
admet-193	642	1	sci	sci	PROPN
admet-193	642	2	.	.	PROPN
admet-193	643	1	38	38	NUM
admet-193	643	2	(	(	PUNCT
admet-193	643	3	1998	1998	NUM
admet-193	643	4	)	)	PUNCT
admet-193	643	5	720	720	NUM
admet-193	643	6	-	-	SYM
admet-193	643	7	725	725	NUM
admet-193	643	8	.	.	PUNCT
admet-193	644	1	[	[	X
admet-193	644	2	68	68	NUM
admet-193	644	3	]	]	X
admet-193	644	4	e.	e.	PROPN
admet-193	644	5	baka	baka	PROPN
admet-193	644	6	,	,	PUNCT
admet-193	644	7	j.e.a	j.e.a	PROPN
admet-193	644	8	.	.	PUNCT
admet-193	644	9	comer	comer	PROPN
admet-193	644	10	,	,	PUNCT
admet-193	644	11	k.	k.	PROPN
admet-193	644	12	takács	takács	PROPN
admet-193	644	13	-	-	PUNCT
admet-193	644	14	novák	novák	PROPN
admet-193	644	15	,	,	PUNCT
admet-193	644	16	j.	j.	PROPN
admet-193	644	17	pharm	pharm	PROPN
admet-193	644	18	.	.	PUNCT
admet-193	644	19	biomed	biome	VERB
admet-193	644	20	.	.	PUNCT
admet-193	645	1	anal	anal	ADJ
admet-193	645	2	.	.	PUNCT
admet-193	646	1	46	46	NUM
admet-193	646	2	(	(	PUNCT
admet-193	646	3	2008	2008	NUM
admet-193	646	4	)	)	PUNCT
admet-193	646	5	335	335	NUM
admet-193	646	6	-	-	SYM
admet-193	646	7	341	341	NUM
admet-193	646	8	.	.	PUNCT
admet-193	647	1	[	[	X
admet-193	647	2	69	69	NUM
admet-193	647	3	]	]	PUNCT
admet-193	647	4	a.	a.	NOUN
admet-193	647	5	avdeef	avdeef	PROPN
admet-193	647	6	,	,	PUNCT
admet-193	647	7	d.	d.	PROPN
admet-193	647	8	voloboy	voloboy	PROPN
admet-193	647	9	,	,	PUNCT
admet-193	647	10	a.	a.	NOUN
admet-193	647	11	foreman	foreman	NOUN
admet-193	647	12	,	,	PUNCT
admet-193	647	13	dissolution	dissolution	NOUN
admet-193	647	14	and	and	CCONJ
admet-193	647	15	solubility	solubility	NOUN
admet-193	647	16	.	.	PUNCT
admet-193	648	1	in	in	ADP
admet-193	648	2	:	:	PUNCT
admet-193	648	3	b.	b.	PROPN
admet-193	648	4	testa	testa	PROPN
admet-193	648	5	,	,	PUNCT
admet-193	648	6	h.	h.	PROPN
admet-193	648	7	van	van	PROPN
admet-193	648	8	de	de	PROPN
admet-193	648	9	waterbeemd	waterbeemd	PROPN
admet-193	648	10	(	(	PUNCT
admet-193	648	11	eds	ed	NOUN
admet-193	648	12	.	.	PUNCT
admet-193	648	13	)	)	PUNCT
admet-193	648	14	.	.	PUNCT
admet-193	649	1	comprehensive	comprehensive	ADJ
admet-193	649	2	medicinal	medicinal	PROPN
admet-193	649	3	chemistry	chemistry	PROPN
admet-193	649	4	ii	ii	PROPN
admet-193	649	5	,	,	PUNCT
admet-193	649	6	elsevier	elsevier	NOUN
admet-193	649	7	:	:	PUNCT
admet-193	649	8	oxford	oxford	PROPN
admet-193	649	9	,	,	PUNCT
admet-193	649	10	uk	uk	PROPN
admet-193	649	11	,	,	PUNCT
admet-193	649	12	2007	2007	NUM
admet-193	649	13	,	,	PUNCT
admet-193	649	14	pp	pp	ADJ
admet-193	649	15	.	.	PUNCT
admet-193	650	1	399	399	NUM
admet-193	650	2	-	-	SYM
admet-193	650	3	423	423	NUM
admet-193	650	4	.	.	PUNCT
admet-193	651	1	[	[	X
admet-193	651	2	70	70	NUM
admet-193	651	3	]	]	PUNCT
admet-193	651	4	a.	a.	NOUN
admet-193	651	5	avdeef	avdeef	PROPN
admet-193	651	6	,	,	PUNCT
admet-193	651	7	o.	o.	PROPN
admet-193	651	8	tsinman	tsinman	NOUN
admet-193	651	9	,	,	PUNCT
admet-193	651	10	pharm	pharm	PROPN
admet-193	651	11	.	.	PUNCT
admet-193	652	1	res	re	NOUN
admet-193	652	2	.	.	PROPN
admet-193	653	1	25	25	NUM
admet-193	653	2	(	(	PUNCT
admet-193	653	3	2008	2008	NUM
admet-193	653	4	)	)	PUNCT
admet-193	653	5	2613	2613	NUM
admet-193	653	6	-	-	SYM
admet-193	653	7	2627	2627	NUM
admet-193	653	8	.	.	PUNCT
admet-193	654	1	[	[	X
admet-193	654	2	71	71	NUM
admet-193	654	3	]	]	PUNCT
admet-193	654	4	k.	k.	PROPN
admet-193	654	5	tsinman	tsinman	PROPN
admet-193	654	6	,	,	PUNCT
admet-193	654	7	a.	a.	NOUN
admet-193	654	8	avdeef	avdeef	PROPN
admet-193	654	9	,	,	PUNCT
admet-193	654	10	o.	o.	PROPN
admet-193	654	11	tsinman	tsinman	PROPN
admet-193	654	12	,	,	PUNCT
admet-193	654	13	d.	d.	PROPN
admet-193	654	14	voloboy	voloboy	PROPN
admet-193	654	15	,	,	PUNCT
admet-193	654	16	pharm	pharm	PROPN
admet-193	654	17	.	.	PUNCT
admet-193	655	1	res	re	NOUN
admet-193	655	2	.	.	PROPN
admet-193	656	1	26	26	NUM
admet-193	656	2	(	(	PUNCT
admet-193	656	3	2009	2009	NUM
admet-193	656	4	)	)	PUNCT
admet-193	656	5	2093	2093	NUM
admet-193	656	6	-	-	SYM
admet-193	656	7	2100	2100	NUM
admet-193	656	8	.	.	PUNCT
admet-193	657	1	[	[	X
admet-193	657	2	72	72	NUM
admet-193	657	3	]	]	X
admet-193	657	4	a.	a.	NOUN
admet-193	657	5	avdeef	avdeef	PROPN
admet-193	657	6	,	,	PUNCT
admet-193	657	7	k.	k.	PROPN
admet-193	657	8	tsinman	tsinman	PROPN
admet-193	657	9	,	,	PUNCT
admet-193	657	10	o.	o.	PROPN
admet-193	657	11	tsinman	tsinman	NOUN
admet-193	657	12	,	,	PUNCT
admet-193	657	13	n.	n.	PROPN
admet-193	657	14	sun	sun	PROPN
admet-193	657	15	,	,	PUNCT
admet-193	657	16	d.	d.	PROPN
admet-193	657	17	voloboy	voloboy	PROPN
admet-193	657	18	,	,	PUNCT
admet-193	657	19	chem	chem	NOUN
admet-193	657	20	.	.	PUNCT
admet-193	658	1	biodiv	biodiv	PROPN
admet-193	658	2	.	.	PUNCT
admet-193	659	1	11	11	NUM
admet-193	659	2	(	(	PUNCT
admet-193	659	3	2009	2009	NUM
admet-193	659	4	)	)	PUNCT
admet-193	659	5	1796	1796	NUM
admet-193	659	6	-	-	SYM
admet-193	659	7	1811	1811	NUM
admet-193	659	8	.	.	PUNCT
admet-193	660	1	[	[	X
admet-193	660	2	73	73	NUM
admet-193	660	3	]	]	X
admet-193	660	4	j.h	j.h	PROPN
admet-193	660	5	.	.	PROPN
admet-193	660	6	fagerberg	fagerberg	PROPN
admet-193	660	7	,	,	PUNCT
admet-193	660	8	o.	o.	PROPN
admet-193	660	9	tsinman	tsinman	PROPN
admet-193	660	10	,	,	PUNCT
admet-193	660	11	k.	k.	PROPN
admet-193	660	12	tsinman	tsinman	PROPN
admet-193	660	13	,	,	PUNCT
admet-193	660	14	n.	n.	PROPN
admet-193	660	15	sun	sun	PROPN
admet-193	660	16	,	,	PUNCT
admet-193	660	17	a.	a.	NOUN
admet-193	660	18	avdeef	avdeef	PROPN
admet-193	660	19	,	,	PUNCT
admet-193	660	20	c.a.s	c.a.s	PROPN
admet-193	660	21	.	.	PROPN
admet-193	660	22	bergström	bergström	PROPN
admet-193	660	23	,	,	PUNCT
admet-193	660	24	mol	mol	PROPN
admet-193	660	25	.	.	PUNCT
admet-193	661	1	pharmaceutics	pharmaceutic	NOUN
admet-193	661	2	7	7	NUM
admet-193	661	3	(	(	PUNCT
admet-193	661	4	2010	2010	NUM
admet-193	661	5	)	)	PUNCT
admet-193	661	6	1419	1419	NUM
admet-193	661	7	-	-	SYM
admet-193	661	8	1430	1430	NUM
admet-193	661	9	.	.	PUNCT
admet-193	662	1	[	[	X
admet-193	662	2	74	74	NUM
admet-193	662	3	]	]	PUNCT
admet-193	662	4	a.	a.	NOUN
admet-193	662	5	avdeef	avdeef	PROPN
admet-193	662	6	,	,	PUNCT
admet-193	662	7	s.	s.	PROPN
admet-193	662	8	bendels	bendels	PROPN
admet-193	662	9	,	,	PUNCT
admet-193	662	10	o.	o.	NOUN
admet-193	662	11	tsinman	tsinman	NOUN
admet-193	662	12	,	,	PUNCT
admet-193	662	13	m.	m.	PROPN
admet-193	662	14	kansy	kansy	PROPN
admet-193	662	15	,	,	PUNCT
admet-193	662	16	pharm	pharm	PROPN
admet-193	662	17	.	.	PUNCT
admet-193	663	1	res	re	NOUN
admet-193	663	2	.	.	PROPN
admet-193	664	1	24	24	NUM
admet-193	664	2	(	(	PUNCT
admet-193	664	3	2007	2007	NUM
admet-193	664	4	)	)	PUNCT
admet-193	664	5	530	530	NUM
admet-193	664	6	-	-	SYM
admet-193	664	7	545	545	NUM
admet-193	664	8	.	.	PUNCT
admet-193	665	1	[	[	X
admet-193	665	2	75	75	NUM
admet-193	665	3	]	]	PUNCT
admet-193	665	4	j.	j.	PROPN
admet-193	665	5	alsenz	alsenz	PROPN
admet-193	665	6	,	,	PUNCT
admet-193	665	7	m.	m.	PROPN
admet-193	665	8	kansy	kansy	PROPN
admet-193	665	9	,	,	PUNCT
admet-193	665	10	adv	adv	PROPN
admet-193	665	11	.	.	PUNCT
admet-193	665	12	drug	drug	PROPN
admet-193	665	13	deliv	deliv	PROPN
admet-193	665	14	.	.	PUNCT
admet-193	665	15	rev	rev	PROPN
admet-193	665	16	.	.	PROPN
admet-193	665	17	59	59	NUM
admet-193	665	18	(	(	PUNCT
admet-193	665	19	2007	2007	NUM
admet-193	665	20	)	)	PUNCT
admet-193	665	21	546–567	546–567	NUM
admet-193	665	22	.	.	PUNCT
admet-193	666	1	[	[	X
admet-193	666	2	76	76	NUM
admet-193	666	3	]	]	X
admet-193	666	4	j.	j.	PROPN
admet-193	666	5	alsenz	alsenz	PROPN
admet-193	666	6	,	,	PUNCT
admet-193	666	7	e.	e.	PROPN
admet-193	666	8	meister	meister	PROPN
admet-193	666	9	,	,	PUNCT
admet-193	666	10	e.	e.	PROPN
admet-193	666	11	haenel	haenel	PROPN
admet-193	666	12	,	,	PUNCT
admet-193	666	13	j.	j.	PROPN
admet-193	666	14	pharm	pharm	PROPN
admet-193	666	15	.	.	PUNCT
admet-193	667	1	sci	sci	PROPN
admet-193	667	2	.	.	PROPN
admet-193	668	1	96	96	NUM
admet-193	668	2	(	(	PUNCT
admet-193	668	3	2007	2007	NUM
admet-193	668	4	)	)	PUNCT
admet-193	668	5	1748	1748	NUM
admet-193	668	6	-	-	SYM
admet-193	668	7	1762	1762	NUM
admet-193	668	8	.	.	PUNCT
admet-193	669	1	[	[	X
admet-193	669	2	77	77	NUM
admet-193	669	3	]	]	PUNCT
admet-193	669	4	c.a.s	c.a.s	PROPN
admet-193	669	5	.	.	PROPN
admet-193	669	6	bergström	bergström	PROPN
admet-193	669	7	,	,	PUNCT
admet-193	669	8	k.	k.	PROPN
admet-193	669	9	luthman	luthman	PROPN
admet-193	669	10	,	,	PUNCT
admet-193	669	11	p.	p.	PROPN
admet-193	669	12	artursson	artursson	PROPN
admet-193	669	13	,	,	PUNCT
admet-193	669	14	eur	eur	PROPN
admet-193	669	15	.	.	PUNCT
admet-193	670	1	j.	j.	PROPN
admet-193	670	2	pharm	pharm	PROPN
admet-193	670	3	.	.	PUNCT
admet-193	671	1	sci	sci	PROPN
admet-193	671	2	.	.	PROPN
admet-193	672	1	22	22	NUM
admet-193	672	2	(	(	PUNCT
admet-193	672	3	2004	2004	NUM
admet-193	672	4	)	)	PUNCT
admet-193	672	5	387	387	NUM
admet-193	672	6	-	-	SYM
admet-193	672	7	398	398	NUM
admet-193	672	8	.	.	PUNCT
admet-193	673	1	avdeef	avdeef	PROPN
admet-193	673	2	admet	admet	PROPN
admet-193	673	3	&	&	CCONJ
admet-193	673	4	dmpk	dmpk	PROPN
admet-193	673	5	3(2	3(2	NUM
admet-193	673	6	)	)	PUNCT
admet-193	673	7	(	(	PUNCT
admet-193	673	8	2015	2015	NUM
admet-193	673	9	)	)	PUNCT
admet-193	673	10	84	84	NUM
admet-193	673	11	-	-	SYM
admet-193	673	12	109	109	NUM
admet-193	673	13	104	104	NUM
admet-193	674	1	[	[	X
admet-193	674	2	78	78	NUM
admet-193	674	3	]	]	PUNCT
admet-193	674	4	a.	a.	NOUN
admet-193	674	5	glomme	glomme	PROPN
admet-193	674	6	,	,	PUNCT
admet-193	674	7	j.	j.	PROPN
admet-193	674	8	märz	märz	PROPN
admet-193	674	9	,	,	PUNCT
admet-193	674	10	j.b	j.b	PROPN
admet-193	674	11	.	.	PROPN
admet-193	674	12	dressman	dressman	PROPN
admet-193	674	13	,	,	PUNCT
admet-193	674	14	j.	j.	PROPN
admet-193	674	15	pharm	pharm	PROPN
admet-193	674	16	.	.	PUNCT
admet-193	675	1	sci	sci	PROPN
admet-193	675	2	.	.	PROPN
admet-193	675	3	,	,	PUNCT
admet-193	675	4	94	94	NUM
admet-193	675	5	(	(	PUNCT
admet-193	675	6	2005	2005	NUM
admet-193	675	7	)	)	PUNCT
admet-193	675	8	1	1	NUM
admet-193	675	9	-	-	SYM
admet-193	675	10	16	16	NUM
admet-193	675	11	.	.	PUNCT
admet-193	676	1	[	[	X
admet-193	676	2	79	79	NUM
admet-193	676	3	]	]	PUNCT
admet-193	676	4	t.	t.	PROPN
admet-193	676	5	higuchi	higuchi	PROPN
admet-193	676	6	,	,	PUNCT
admet-193	676	7	f.m	f.m	PROPN
admet-193	676	8	.	.	PROPN
admet-193	676	9	shih	shih	NOUN
admet-193	676	10	,	,	PUNCT
admet-193	676	11	t.	t.	PROPN
admet-193	676	12	kimura	kimura	PROPN
admet-193	676	13	,	,	PUNCT
admet-193	676	14	j.h	j.h	PROPN
admet-193	676	15	.	.	PROPN
admet-193	676	16	rytting	rytting	NOUN
admet-193	676	17	,	,	PUNCT
admet-193	676	18	j.	j.	PROPN
admet-193	676	19	pharm	pharm	PROPN
admet-193	676	20	.	.	PUNCT
admet-193	677	1	sci	sci	PROPN
admet-193	677	2	.	.	PROPN
admet-193	678	1	68	68	NUM
admet-193	678	2	(	(	PUNCT
admet-193	678	3	1979	1979	NUM
admet-193	678	4	)	)	PUNCT
admet-193	678	5	1267	1267	NUM
admet-193	678	6	-	-	SYM
admet-193	678	7	1272	1272	NUM
admet-193	678	8	.	.	PUNCT
admet-193	679	1	[	[	X
admet-193	679	2	80	80	NUM
admet-193	679	3	]	]	X
admet-193	679	4	w.h	w.h	PROPN
admet-193	679	5	.	.	PROPN
admet-193	679	6	streng	streng	PROPN
admet-193	679	7	,	,	PUNCT
admet-193	679	8	s.k	s.k	PROPN
admet-193	679	9	.	.	PUNCT
admet-193	680	1	his	his	PRON
admet-193	680	2	,	,	PUNCT
admet-193	680	3	p.e	p.e	PROPN
admet-193	680	4	.	.	PROPN
admet-193	680	5	helms	helm	NOUN
admet-193	680	6	,	,	PUNCT
admet-193	680	7	h.g.h	h.g.h	NOUN
admet-193	680	8	.	.	PUNCT
admet-193	681	1	tan	tan	PROPN
admet-193	681	2	,	,	PUNCT
admet-193	681	3	j.	j.	PROPN
admet-193	681	4	pharm	pharm	PROPN
admet-193	681	5	.	.	PUNCT
admet-193	682	1	sci	sci	PROPN
admet-193	682	2	.	.	PROPN
admet-193	683	1	73	73	NUM
admet-193	683	2	(	(	PUNCT
admet-193	683	3	1984	1984	NUM
admet-193	683	4	)	)	PUNCT
admet-193	683	5	1679	1679	NUM
admet-193	683	6	-	-	SYM
admet-193	683	7	1684	1684	NUM
admet-193	683	8	.	.	PUNCT
admet-193	684	1	[	[	X
admet-193	684	2	81	81	NUM
admet-193	684	3	]	]	PUNCT
admet-193	684	4	f.	f.	PROPN
admet-193	684	5	wohnsland	wohnsland	PROPN
admet-193	684	6	,	,	PUNCT
admet-193	684	7	b.	b.	PROPN
admet-193	684	8	faller	faller	PROPN
admet-193	684	9	,	,	PUNCT
admet-193	684	10	j.	j.	PROPN
admet-193	684	11	med	med	PROPN
admet-193	684	12	.	.	PROPN
admet-193	684	13	chem	chem	PROPN
admet-193	684	14	.	.	PUNCT
admet-193	685	1	44	44	NUM
admet-193	685	2	(	(	PUNCT
admet-193	685	3	2001	2001	NUM
admet-193	685	4	)	)	PUNCT
admet-193	685	5	923	923	NUM
admet-193	685	6	-	-	SYM
admet-193	685	7	930	930	NUM
admet-193	685	8	.	.	PUNCT
admet-193	686	1	[	[	X
admet-193	686	2	82	82	NUM
admet-193	686	3	]	]	X
admet-193	686	4	g.	g.	PROPN
admet-193	686	5	völgyi	völgyi	PROPN
admet-193	686	6	,	,	PUNCT
admet-193	686	7	e.	e.	PROPN
admet-193	686	8	baka	baka	PROPN
admet-193	686	9	,	,	PUNCT
admet-193	686	10	k.j	k.j	PROPN
admet-193	686	11	.	.	PROPN
admet-193	686	12	box	box	PROPN
admet-193	686	13	,	,	PUNCT
admet-193	686	14	j.e.a	j.e.a	PROPN
admet-193	686	15	.	.	PUNCT
admet-193	686	16	comer	comer	PROPN
admet-193	686	17	,	,	PUNCT
admet-193	686	18	k.	k.	PROPN
admet-193	686	19	takács	takács	PROPN
admet-193	686	20	-	-	PUNCT
admet-193	686	21	novák	novák	PROPN
admet-193	686	22	,	,	PUNCT
admet-193	686	23	anal.chim	anal.chim	PROPN
admet-193	686	24	.	.	PUNCT
admet-193	687	1	acta	acta	PROPN
admet-193	687	2	673	673	NUM
admet-193	687	3	(	(	PUNCT
admet-193	687	4	2010	2010	NUM
admet-193	687	5	)	)	PUNCT
admet-193	687	6	40–46	40–46	NUM
admet-193	687	7	.	.	PUNCT
admet-193	688	1	admet	admet	PROPN
admet-193	688	2	&	&	CCONJ
admet-193	688	3	dmpk	dmpk	PROPN
admet-193	688	4	3(2	3(2	NUM
admet-193	688	5	)	)	PUNCT
admet-193	688	6	(	(	PUNCT
admet-193	688	7	2015	2015	NUM
admet-193	688	8	)	)	PUNCT
admet-193	688	9	84	84	NUM
admet-193	688	10	-	-	SYM
admet-193	688	11	109	109	NUM
admet-193	688	12	equilibrium	equilibrium	NOUN
admet-193	688	13	solubility	solubility	NOUN
admet-193	688	14	measurements	measurement	NOUN
admet-193	688	15	improvements	improvement	NOUN
admet-193	688	16	doi	doi	NOUN
admet-193	688	17	:	:	PUNCT
admet-193	688	18	10.5599	10.5599	NUM
admet-193	688	19	/	/	SYM
admet-193	688	20	admet.3.2.193	admet.3.2.193	PROPN
admet-193	688	21	105	105	NUM
admet-193	688	22	appendix	appendix	ADJ
admet-193	688	23	brief	brief	ADJ
admet-193	688	24	summary	summary	NOUN
admet-193	688	25	of	of	ADP
admet-193	688	26	methods	method	NOUN
admet-193	688	27	suitable	suitable	ADJ
admet-193	688	28	for	for	ADP
admet-193	688	29	measuring	measure	VERB
admet-193	688	30	equilibrium	equilibrium	NOUN
admet-193	688	31	solubility	solubility	NOUN
admet-193	688	32	the	the	DET
admet-193	688	33	appendix	appendix	NOUN
admet-193	688	34	briefly	briefly	NOUN
admet-193	688	35	describes	describe	VERB
admet-193	688	36	methods	method	NOUN
admet-193	688	37	which	which	PRON
admet-193	688	38	can	can	AUX
admet-193	688	39	potentially	potentially	ADV
admet-193	688	40	be	be	AUX
admet-193	688	41	used	use	VERB
admet-193	688	42	to	to	PART
admet-193	688	43	generate	generate	VERB
admet-193	688	44	intrinsic	intrinsic	ADJ
admet-193	688	45	solubility	solubility	NOUN
admet-193	688	46	of	of	ADP
admet-193	688	47	sparingly	sparingly	ADV
admet-193	688	48	-	-	PUNCT
admet-193	688	49	soluble	soluble	ADJ
admet-193	688	50	drugs	drug	NOUN
admet-193	688	51	.	.	PUNCT
admet-193	689	1	kinetic	kinetic	ADJ
admet-193	689	2	methods	method	NOUN
admet-193	689	3	are	be	AUX
admet-193	689	4	not	not	PART
admet-193	689	5	suitable	suitable	ADJ
admet-193	689	6	for	for	ADP
admet-193	689	7	such	such	ADJ
admet-193	689	8	application	application	NOUN
admet-193	689	9	,	,	PUNCT
admet-193	689	10	and	and	CCONJ
admet-193	689	11	are	be	AUX
admet-193	689	12	thus	thus	ADV
admet-193	689	13	not	not	PART
admet-193	689	14	considered	consider	VERB
admet-193	689	15	.	.	PUNCT
admet-193	690	1	classical	classical	ADJ
admet-193	690	2	saturation	saturation	NOUN
admet-193	690	3	shake	shake	NOUN
admet-193	690	4	-	-	PUNCT
admet-193	690	5	flask	flask	NOUN
admet-193	690	6	(	(	PUNCT
admet-193	690	7	sf	sf	PROPN
admet-193	690	8	)	)	PUNCT
admet-193	690	9	–	–	PUNCT
admet-193	690	10	still	still	ADV
admet-193	690	11	the	the	DET
admet-193	690	12	‘	'	PUNCT
admet-193	690	13	gold	gold	ADJ
admet-193	690	14	standard	standard	NOUN
admet-193	690	15	’	'	PUNCT
admet-193	690	16	solubility	solubility	NOUN
admet-193	690	17	measurement	measurement	NOUN
admet-193	690	18	as	as	ADP
admet-193	690	19	a	a	DET
admet-193	690	20	function	function	NOUN
admet-193	690	21	of	of	ADP
admet-193	690	22	ph	ph	NOUN
admet-193	690	23	under	under	ADP
admet-193	690	24	equilibrium	equilibrium	NOUN
admet-193	690	25	conditions	condition	NOUN
admet-193	690	26	usually	usually	ADV
admet-193	690	27	requires	require	VERB
admet-193	690	28	long	long	ADJ
admet-193	690	29	equilibration	equilibration	NOUN
admet-193	690	30	times	time	NOUN
admet-193	690	31	(	(	PUNCT
admet-193	690	32	12	12	NUM
admet-193	690	33	h	h	NOUN
admet-193	690	34	7	7	NUM
admet-193	690	35	d	d	NOUN
admet-193	690	36	)	)	PUNCT
admet-193	690	37	.	.	PUNCT
admet-193	691	1	the	the	DET
admet-193	691	2	shake	shake	NOUN
admet-193	691	3	-	-	PUNCT
admet-193	691	4	flask	flask	NOUN
admet-193	691	5	(	(	PUNCT
admet-193	691	6	sf	sf	NOUN
admet-193	691	7	)	)	PUNCT
admet-193	691	8	method	method	NOUN
admet-193	691	9	is	be	AUX
admet-193	691	10	a	a	DET
admet-193	691	11	relatively	relatively	ADV
admet-193	691	12	simple	simple	ADJ
admet-193	691	13	procedure	procedure	NOUN
admet-193	691	14	:	:	PUNCT
admet-193	691	15	the	the	DET
admet-193	691	16	drug	drug	NOUN
admet-193	691	17	is	be	AUX
admet-193	691	18	added	add	VERB
admet-193	691	19	as	as	ADP
admet-193	691	20	solid	solid	ADJ
admet-193	691	21	to	to	ADP
admet-193	691	22	a	a	DET
admet-193	691	23	standard	standard	ADJ
admet-193	691	24	buffer	buffer	NOUN
admet-193	691	25	solution	solution	NOUN
admet-193	691	26	(	(	PUNCT
admet-193	691	27	in	in	ADP
admet-193	691	28	a	a	DET
admet-193	691	29	flask	flask	NOUN
admet-193	691	30	)	)	PUNCT
admet-193	691	31	until	until	SCONJ
admet-193	691	32	saturation	saturation	NOUN
admet-193	691	33	occurs	occur	VERB
admet-193	691	34	,	,	PUNCT
admet-193	691	35	indicated	indicate	VERB
admet-193	691	36	by	by	ADP
admet-193	691	37	excess	excess	ADJ
admet-193	691	38	undissolved	undissolve	VERB
admet-193	691	39	drug	drug	NOUN
admet-193	691	40	.	.	PUNCT
admet-193	692	1	the	the	DET
admet-193	692	2	thermostated	thermostat	VERB
admet-193	692	3	saturated	saturate	VERB
admet-193	692	4	solution	solution	NOUN
admet-193	692	5	is	be	AUX
admet-193	692	6	shaken	shake	VERB
admet-193	692	7	as	as	ADP
admet-193	692	8	the	the	DET
admet-193	692	9	suspension	suspension	NOUN
admet-193	692	10	equilibrates	equilibrate	VERB
admet-193	692	11	.	.	PUNCT
admet-193	693	1	after	after	ADP
admet-193	693	2	filtration	filtration	NOUN
admet-193	693	3	or	or	CCONJ
admet-193	693	4	centrifugation	centrifugation	NOUN
admet-193	693	5	,	,	PUNCT
admet-193	693	6	the	the	DET
admet-193	693	7	concentration	concentration	NOUN
admet-193	693	8	of	of	ADP
admet-193	693	9	the	the	DET
admet-193	693	10	substance	substance	NOUN
admet-193	693	11	in	in	ADP
admet-193	693	12	the	the	DET
admet-193	693	13	supernatant	supernatant	NOUN
admet-193	693	14	solution	solution	NOUN
admet-193	693	15	is	be	AUX
admet-193	693	16	then	then	ADV
admet-193	693	17	determined	determine	VERB
admet-193	693	18	using	use	VERB
admet-193	693	19	hplc	hplc	NOUN
admet-193	693	20	,	,	PUNCT
admet-193	693	21	usually	usually	ADV
admet-193	693	22	with	with	ADP
admet-193	693	23	uv	uv	NOUN
admet-193	693	24	detection	detection	NOUN
admet-193	693	25	.	.	PUNCT
admet-193	694	1	for	for	ADP
admet-193	694	2	a	a	DET
admet-193	694	3	solubility	solubility	NOUN
admet-193	694	4	-	-	PUNCT
admet-193	694	5	ph	ph	ADJ
admet-193	694	6	profile	profile	NOUN
admet-193	694	7	,	,	PUNCT
admet-193	694	8	parallel	parallel	ADJ
admet-193	694	9	measurements	measurement	NOUN
admet-193	694	10	need	need	VERB
admet-193	694	11	to	to	PART
admet-193	694	12	be	be	AUX
admet-193	694	13	performed	perform	VERB
admet-193	694	14	in	in	ADP
admet-193	694	15	several	several	ADJ
admet-193	694	16	different	different	ADJ
admet-193	694	17	ph	ph	ADJ
admet-193	694	18	buffers	buffer	NOUN
admet-193	694	19	.	.	PUNCT
admet-193	695	1	baka	baka	PROPN
admet-193	695	2	et	et	PROPN
admet-193	695	3	al	al	PROPN
admet-193	695	4	.	.	PUNCT
admet-193	696	1	[	[	X
admet-193	696	2	68	68	NUM
admet-193	696	3	]	]	PUNCT
admet-193	696	4	suggested	suggest	VERB
admet-193	696	5	concrete	concrete	ADJ
admet-193	696	6	ways	way	NOUN
admet-193	696	7	to	to	PART
admet-193	696	8	improve	improve	VERB
admet-193	696	9	the	the	DET
admet-193	696	10	quality	quality	NOUN
admet-193	696	11	of	of	ADP
admet-193	696	12	the	the	DET
admet-193	696	13	sf	sf	PROPN
admet-193	696	14	measurements	measurement	NOUN
admet-193	696	15	.	.	PUNCT
admet-193	697	1	in	in	ADP
admet-193	697	2	high	high	ADJ
admet-193	697	3	-	-	PUNCT
admet-193	697	4	quality	quality	NOUN
admet-193	697	5	sf	sf	NOUN
admet-193	697	6	measurements	measurement	NOUN
admet-193	697	7	,	,	PUNCT
admet-193	697	8	(	(	PUNCT
admet-193	697	9	a	a	X
admet-193	697	10	)	)	PUNCT
admet-193	697	11	it	it	PRON
admet-193	697	12	is	be	AUX
admet-193	697	13	actually	actually	ADV
admet-193	697	14	verified	verify	VERB
admet-193	697	15	that	that	SCONJ
admet-193	697	16	the	the	DET
admet-193	697	17	dissolution	dissolution	NOUN
admet-193	697	18	/	/	SYM
admet-193	697	19	precipitation	precipitation	NOUN
admet-193	697	20	of	of	ADP
admet-193	697	21	the	the	DET
admet-193	697	22	solid	solid	NOUN
admet-193	697	23	has	have	AUX
admet-193	697	24	reached	reach	VERB
admet-193	697	25	equilibrium	equilibrium	NOUN
admet-193	697	26	,	,	PUNCT
admet-193	697	27	(	(	PUNCT
admet-193	697	28	b	b	X
admet-193	697	29	)	)	PUNCT
admet-193	697	30	the	the	DET
admet-193	697	31	final	final	ADJ
admet-193	697	32	(	(	PUNCT
admet-193	697	33	equilibrium	equilibrium	NOUN
admet-193	697	34	)	)	PUNCT
admet-193	697	35	ph	ph	NOUN
admet-193	697	36	is	be	AUX
admet-193	697	37	measured	measure	VERB
admet-193	697	38	,	,	PUNCT
admet-193	697	39	and	and	CCONJ
admet-193	697	40	(	(	PUNCT
admet-193	697	41	c	c	X
admet-193	697	42	)	)	PUNCT
admet-193	697	43	the	the	DET
admet-193	697	44	equilibrated	equilibrate	VERB
admet-193	697	45	solid	solid	NOUN
admet-193	697	46	is	be	AUX
admet-193	697	47	isolated	isolate	VERB
admet-193	697	48	and	and	CCONJ
admet-193	697	49	identified	identify	VERB
admet-193	697	50	(	(	PUNCT
admet-193	697	51	or	or	CCONJ
admet-193	697	52	characterized	characterize	VERB
admet-193	697	53	)	)	PUNCT
admet-193	697	54	.	.	PUNCT
admet-193	698	1	the	the	DET
admet-193	698	2	measured	measure	VERB
admet-193	698	3	solubility	solubility	NOUN
admet-193	698	4	is	be	AUX
admet-193	698	5	expected	expect	VERB
admet-193	698	6	to	to	PART
admet-193	698	7	be	be	AUX
admet-193	698	8	that	that	PRON
admet-193	698	9	of	of	ADP
admet-193	698	10	the	the	DET
admet-193	698	11	most	most	ADV
admet-193	698	12	stable	stable	ADJ
admet-193	698	13	polymorph	polymorph	NOUN
admet-193	698	14	,	,	PUNCT
admet-193	698	15	which	which	PRON
admet-193	698	16	can	can	AUX
admet-193	698	17	often	often	ADV
admet-193	698	18	be	be	AUX
admet-193	698	19	a	a	DET
admet-193	698	20	hydrate	hydrate	NOUN
admet-193	698	21	.	.	PUNCT
admet-193	699	1	micro	micro	NOUN
admet-193	699	2	-	-	NOUN
admet-193	699	3	dissolution	dissolution	NOUN
admet-193	699	4	for	for	ADP
admet-193	699	5	polymorph	polymorph	NOUN
admet-193	699	6	/	/	SYM
admet-193	699	7	solvate	solvate	NOUN
admet-193	699	8	solubility	solubility	NOUN
admet-193	699	9	measurement	measurement	NOUN
admet-193	699	10	(	(	PUNCT
admet-193	699	11	μdiss	μdiss	NOUN
admet-193	699	12	profiler	profiler	NOUN
admet-193	699	13	)	)	PUNCT
admet-193	699	14	by	by	ADP
admet-193	699	15	usp	usp	PROPN
admet-193	699	16	standards	standard	NOUN
admet-193	699	17	,	,	PUNCT
admet-193	699	18	dissolution	dissolution	ADJ
admet-193	699	19	equipment	equipment	NOUN
admet-193	699	20	typically	typically	ADV
admet-193	699	21	uses	use	VERB
admet-193	699	22	900	900	NUM
admet-193	699	23	-	-	PUNCT
admet-193	699	24	ml	ml	NOUN
admet-193	699	25	solution	solution	NOUN
admet-193	699	26	volumes	volume	NOUN
admet-193	699	27	,	,	PUNCT
admet-193	699	28	so	so	SCONJ
admet-193	699	29	it	it	PRON
admet-193	699	30	would	would	AUX
admet-193	699	31	be	be	AUX
admet-193	699	32	impractical	impractical	ADJ
admet-193	699	33	to	to	PART
admet-193	699	34	determine	determine	VERB
admet-193	699	35	solubility	solubility	NOUN
admet-193	699	36	of	of	ADP
admet-193	699	37	drugs	drug	NOUN
admet-193	699	38	,	,	PUNCT
admet-193	699	39	since	since	SCONJ
admet-193	699	40	an	an	DET
admet-193	699	41	excessive	excessive	ADJ
admet-193	699	42	amount	amount	NOUN
admet-193	699	43	of	of	ADP
admet-193	699	44	compound	compound	NOUN
admet-193	699	45	would	would	AUX
admet-193	699	46	be	be	AUX
admet-193	699	47	required	require	VERB
admet-193	699	48	to	to	PART
admet-193	699	49	form	form	VERB
admet-193	699	50	a	a	DET
admet-193	699	51	saturated	saturate	VERB
admet-193	699	52	solution	solution	NOUN
admet-193	699	53	.	.	PUNCT
admet-193	700	1	however	however	ADV
admet-193	700	2	,	,	PUNCT
admet-193	700	3	the	the	DET
admet-193	700	4	miniaturized	miniaturize	VERB
admet-193	700	5	-	-	PUNCT
admet-193	700	6	volume	volume	NOUN
admet-193	700	7	dissolution	dissolution	NOUN
admet-193	700	8	apparatus	apparatus	NOUN
admet-193	700	9	,	,	PUNCT
admet-193	700	10	µdiss	µdiss	NOUN
admet-193	700	11	profiler	profiler	NOUN
admet-193	700	12	(	(	PUNCT
admet-193	700	13	pion	pion	PROPN
admet-193	700	14	inc	inc	PROPN
admet-193	700	15	.	.	PROPN
admet-193	700	16	)	)	PUNCT
admet-193	700	17	,	,	PUNCT
admet-193	700	18	uses	use	VERB
admet-193	700	19	1.0	1.0	NUM
admet-193	700	20	ml	ml	NOUN
admet-193	700	21	working	work	VERB
admet-193	700	22	volumes	volume	NOUN
admet-193	700	23	and	and	CCONJ
admet-193	700	24	makes	make	VERB
admet-193	700	25	it	it	PRON
admet-193	700	26	practical	practical	ADJ
admet-193	700	27	to	to	PART
admet-193	700	28	determine	determine	VERB
admet-193	700	29	solubility	solubility	NOUN
admet-193	700	30	(	(	PUNCT
admet-193	700	31	avdeef	avdeef	NOUN
admet-193	700	32	et	et	PROPN
admet-193	700	33	al	al	PROPN
admet-193	700	34	.	.	PUNCT
admet-193	701	1	[	[	X
admet-193	701	2	69	69	NUM
admet-193	701	3	]	]	X
admet-193	701	4	;	;	PUNCT
admet-193	701	5	avdeef	avdeef	NOUN
admet-193	701	6	and	and	CCONJ
admet-193	701	7	tsinman	tsinman	NOUN
admet-193	701	8	[	[	X
admet-193	701	9	70	70	NUM
admet-193	701	10	]	]	PUNCT
admet-193	701	11	;	;	PUNCT
admet-193	701	12	tsinman	tsinman	NOUN
admet-193	701	13	et	et	PROPN
admet-193	701	14	al	al	PROPN
admet-193	701	15	.	.	PUNCT
admet-193	702	1	[	[	X
admet-193	702	2	71	71	NUM
admet-193	702	3	]	]	X
admet-193	702	4	;	;	PUNCT
admet-193	702	5	avdeef	avdeef	PROPN
admet-193	702	6	et	et	PROPN
admet-193	702	7	al	al	PROPN
admet-193	702	8	.	.	PUNCT
admet-193	703	1	[	[	X
admet-193	703	2	72	72	NUM
admet-193	703	3	]	]	X
admet-193	703	4	;	;	PUNCT
admet-193	703	5	fagerberg	fagerberg	PROPN
admet-193	703	6	et	et	PROPN
admet-193	703	7	al	al	PROPN
admet-193	703	8	.	.	PUNCT
admet-193	704	1	[	[	X
admet-193	704	2	73	73	NUM
admet-193	704	3	]	]	PUNCT
admet-193	704	4	)	)	PUNCT
admet-193	704	5	.	.	PUNCT
admet-193	705	1	since	since	SCONJ
admet-193	705	2	the	the	DET
admet-193	705	3	instrument	instrument	NOUN
admet-193	705	4	uses	use	VERB
admet-193	705	5	in	in	ADP
admet-193	705	6	situ	situ	ADJ
admet-193	705	7	fiber	fiber	NOUN
admet-193	705	8	optic	optic	NOUN
admet-193	705	9	uv	uv	NOUN
admet-193	705	10	(	(	PUNCT
admet-193	705	11	diode	diode	NOUN
admet-193	705	12	array	array	NOUN
admet-193	705	13	)	)	PUNCT
admet-193	705	14	detection	detection	NOUN
admet-193	705	15	,	,	PUNCT
admet-193	705	16	the	the	DET
admet-193	705	17	progression	progression	NOUN
admet-193	705	18	of	of	ADP
admet-193	705	19	dissolution	dissolution	NOUN
admet-193	705	20	may	may	AUX
admet-193	705	21	be	be	AUX
admet-193	705	22	followed	follow	VERB
admet-193	705	23	in	in	ADP
admet-193	705	24	real	real	ADJ
admet-193	705	25	time	time	NOUN
admet-193	705	26	,	,	PUNCT
admet-193	705	27	making	make	VERB
admet-193	705	28	it	it	PRON
admet-193	705	29	possible	possible	ADJ
admet-193	705	30	to	to	PART
admet-193	705	31	characterize	characterize	VERB
admet-193	705	32	the	the	DET
admet-193	705	33	(	(	PUNCT
admet-193	705	34	transient	transient	NOUN
admet-193	705	35	)	)	PUNCT
admet-193	705	36	solubility	solubility	NOUN
admet-193	705	37	of	of	ADP
admet-193	705	38	different	different	ADJ
admet-193	705	39	polymorphs	polymorph	NOUN
admet-193	705	40	/	/	SYM
admet-193	705	41	solvates	solvate	NOUN
admet-193	705	42	,	,	PUNCT
admet-193	705	43	over	over	ADP
admet-193	705	44	periods	period	NOUN
admet-193	705	45	of	of	ADP
admet-193	705	46	days	day	NOUN
admet-193	705	47	,	,	PUNCT
admet-193	705	48	if	if	SCONJ
admet-193	705	49	necessary	necessary	ADJ
admet-193	705	50	.	.	PUNCT
admet-193	706	1	it	it	PRON
admet-193	706	2	has	have	AUX
admet-193	706	3	been	be	AUX
admet-193	706	4	demonstrated	demonstrate	VERB
admet-193	706	5	that	that	SCONJ
admet-193	706	6	10	10	NUM
admet-193	706	7	-	-	SYM
admet-193	706	8	100	100	NUM
admet-193	706	9	μg	μg	NOUN
admet-193	706	10	of	of	ADP
admet-193	706	11	powder	powder	NOUN
admet-193	706	12	can	can	AUX
admet-193	706	13	be	be	AUX
admet-193	706	14	characterized	characterize	VERB
admet-193	706	15	for	for	ADP
admet-193	706	16	both	both	CCONJ
admet-193	706	17	the	the	DET
admet-193	706	18	transient	transient	ADJ
admet-193	706	19	polymorph	polymorph	NOUN
admet-193	706	20	solubility	solubility	NOUN
admet-193	706	21	and	and	CCONJ
admet-193	706	22	equilibrium	equilibrium	NOUN
admet-193	706	23	solubility	solubility	NOUN
admet-193	706	24	of	of	ADP
admet-193	706	25	the	the	DET
admet-193	706	26	most	most	ADV
admet-193	706	27	stable	stable	ADJ
admet-193	706	28	form	form	NOUN
admet-193	706	29	of	of	ADP
admet-193	706	30	the	the	DET
admet-193	706	31	solid	solid	NOUN
admet-193	706	32	.	.	PUNCT
admet-193	707	1	a	a	DET
admet-193	707	2	hydroxypropyl	hydroxypropyl	NOUN
admet-193	707	3	-	-	PUNCT
admet-193	707	4	β	β	NOUN
admet-193	707	5	-	-	PUNCT
admet-193	707	6	cyclodextrin	cyclodextrin	NOUN
admet-193	707	7	phase	phase	NOUN
admet-193	707	8	-	-	PUNCT
admet-193	707	9	solubility	solubility	NOUN
admet-193	707	10	study	study	NOUN
admet-193	707	11	of	of	ADP
admet-193	707	12	itraconazole	itraconazole	PROPN
admet-193	707	13	using	use	VERB
admet-193	707	14	the	the	DET
admet-193	707	15	micro	micro	ADJ
admet-193	707	16	-	-	NOUN
admet-193	707	17	dissolution	dissolution	ADJ
admet-193	707	18	apparatus	apparatus	NOUN
admet-193	707	19	estimated	estimate	VERB
admet-193	707	20	the	the	DET
admet-193	707	21	active	active	ADJ
admet-193	707	22	polymorph	polymorph	NOUN
admet-193	707	23	solubility	solubility	NOUN
admet-193	707	24	of	of	ADP
admet-193	707	25	itraconazole	itraconazole	NOUN
admet-193	707	26	to	to	PART
admet-193	707	27	be	be	AUX
admet-193	707	28	<	<	X
admet-193	707	29	9	9	NUM
admet-193	707	30	ng	ng	PROPN
admet-193	707	31	/	/	SYM
admet-193	707	32	ml	ml	PROPN
admet-193	707	33	.	.	PUNCT
admet-193	708	1	equilibrium	equilibrium	NOUN
admet-193	708	2	96	96	NUM
admet-193	708	3	-	-	PUNCT
admet-193	708	4	well	well	NOUN
admet-193	708	5	microtitre	microtitre	NOUN
admet-193	708	6	plate	plate	NOUN
admet-193	708	7	methods	method	NOUN
admet-193	708	8	to	to	PART
admet-193	708	9	increase	increase	VERB
admet-193	708	10	throughput	throughput	NOUN
admet-193	708	11	and	and	CCONJ
admet-193	708	12	decrease	decrease	VERB
admet-193	708	13	sample	sample	NOUN
admet-193	708	14	consumption	consumption	NOUN
admet-193	708	15	,	,	PUNCT
admet-193	708	16	several	several	ADJ
admet-193	708	17	pharmaceutical	pharmaceutical	ADJ
admet-193	708	18	companies	company	NOUN
admet-193	708	19	have	have	AUX
admet-193	708	20	transferred	transfer	VERB
admet-193	708	21	the	the	DET
admet-193	708	22	larger	large	ADJ
admet-193	708	23	-	-	PUNCT
admet-193	708	24	volume	volume	NOUN
admet-193	708	25	classical	classical	ADJ
admet-193	708	26	sf	sf	PROPN
admet-193	708	27	method	method	NOUN
admet-193	708	28	to	to	ADP
admet-193	708	29	smaller	small	ADJ
admet-193	708	30	-	-	PUNCT
admet-193	708	31	volume	volume	NOUN
admet-193	708	32	96	96	NUM
admet-193	708	33	-	-	PUNCT
admet-193	708	34	well	well	PROPN
admet-193	708	35	microtitre	microtitre	NOUN
admet-193	708	36	plate	plate	NOUN
admet-193	708	37	format	format	NOUN
admet-193	708	38	linked	link	VERB
admet-193	708	39	to	to	ADP
admet-193	708	40	robotic	robotic	ADJ
admet-193	708	41	liquid	liquid	ADJ
admet-193	708	42	handling	handling	NOUN
admet-193	708	43	systems	system	NOUN
admet-193	708	44	,	,	PUNCT
admet-193	708	45	using	use	VERB
admet-193	708	46	several	several	ADJ
admet-193	708	47	distinct	distinct	ADJ
admet-193	708	48	approaches	approach	NOUN
admet-193	708	49	(	(	PUNCT
admet-193	708	50	including	include	VERB
admet-193	708	51	those	those	PRON
admet-193	708	52	which	which	PRON
admet-193	708	53	avoid	avoid	VERB
admet-193	708	54	use	use	NOUN
admet-193	708	55	of	of	ADP
admet-193	708	56	dmso	dmso	NOUN
admet-193	708	57	)	)	PUNCT
admet-193	708	58	.	.	PUNCT
admet-193	709	1	there	there	PRON
admet-193	709	2	are	be	VERB
admet-193	709	3	trade	trade	NOUN
admet-193	709	4	-	-	PUNCT
admet-193	709	5	offs	off	NOUN
admet-193	709	6	in	in	ADP
admet-193	709	7	the	the	DET
admet-193	709	8	high	high	ADJ
admet-193	709	9	-	-	PUNCT
admet-193	709	10	throughput	throughput	NOUN
admet-193	709	11	methods	method	NOUN
admet-193	709	12	,	,	PUNCT
admet-193	709	13	and	and	CCONJ
admet-193	709	14	usually	usually	ADV
admet-193	709	15	,	,	PUNCT
admet-193	709	16	the	the	DET
admet-193	709	17	quality	quality	NOUN
admet-193	709	18	of	of	ADP
admet-193	709	19	the	the	DET
admet-193	709	20	data	datum	NOUN
admet-193	709	21	are	be	AUX
admet-193	709	22	not	not	PART
admet-193	709	23	expected	expect	VERB
admet-193	709	24	to	to	PART
admet-193	709	25	be	be	AUX
admet-193	709	26	as	as	ADV
admet-193	709	27	accurate	accurate	ADJ
admet-193	709	28	as	as	ADP
admet-193	709	29	those	those	PRON
admet-193	709	30	obtained	obtain	VERB
admet-193	709	31	by	by	ADP
admet-193	709	32	the	the	DET
admet-193	709	33	sf	sf	PROPN
admet-193	709	34	method	method	NOUN
admet-193	709	35	.	.	PUNCT
admet-193	710	1	since	since	SCONJ
admet-193	710	2	the	the	DET
admet-193	710	3	compound	compound	NOUN
admet-193	710	4	is	be	AUX
admet-193	710	5	usually	usually	ADV
admet-193	710	6	introduced	introduce	VERB
admet-193	710	7	as	as	ADP
admet-193	710	8	aliquots	aliquot	NOUN
admet-193	710	9	of	of	ADP
admet-193	710	10	a	a	DET
admet-193	710	11	10	10	NUM
admet-193	710	12	mm	mm	PROPN
admet-193	710	13	dmso	dmso	NOUN
admet-193	710	14	stock	stock	NOUN
admet-193	710	15	solution	solution	NOUN
admet-193	710	16	,	,	PUNCT
admet-193	710	17	such	such	ADJ
admet-193	710	18	methods	method	NOUN
admet-193	710	19	have	have	VERB
admet-193	710	20	an	an	DET
admet-193	710	21	upper	upper	ADJ
admet-193	710	22	solubility	solubility	NOUN
admet-193	710	23	limit	limit	NOUN
admet-193	710	24	,	,	PUNCT
admet-193	710	25	typically	typically	ADV
admet-193	710	26	less	less	ADJ
admet-193	710	27	than	than	ADP
admet-193	710	28	150	150	NUM
admet-193	710	29	μm	μm	NOUN
admet-193	710	30	.	.	PUNCT
admet-193	711	1	also	also	ADV
admet-193	711	2	,	,	PUNCT
admet-193	711	3	the	the	DET
admet-193	711	4	presence	presence	NOUN
admet-193	711	5	of	of	ADP
admet-193	711	6	the	the	DET
admet-193	711	7	small	small	ADJ
admet-193	711	8	amount	amount	NOUN
admet-193	711	9	of	of	ADP
admet-193	711	10	dmso	dmso	NOUN
admet-193	711	11	in	in	ADP
admet-193	711	12	the	the	DET
admet-193	711	13	final	final	ADJ
admet-193	711	14	buffer	buffer	NOUN
admet-193	711	15	solution	solution	NOUN
admet-193	711	16	increases	increase	VERB
admet-193	711	17	the	the	DET
admet-193	711	18	measured	measured	ADJ
admet-193	711	19	solubility	solubility	NOUN
admet-193	711	20	values	value	NOUN
admet-193	711	21	of	of	ADP
admet-193	711	22	the	the	DET
admet-193	711	23	most	most	ADV
admet-193	711	24	insoluble	insoluble	ADJ
admet-193	711	25	compounds	compound	NOUN
admet-193	711	26	by	by	ADP
admet-193	711	27	up	up	ADP
admet-193	711	28	to	to	PART
admet-193	711	29	100	100	NUM
admet-193	711	30	-	-	NUM
admet-193	711	31	fold	fold	ADJ
admet-193	711	32	(	(	PUNCT
admet-193	711	33	e.g.	e.g.	ADJ
admet-193	711	34	,	,	PUNCT
admet-193	711	35	glibenclamide	glibenclamide	ADJ
admet-193	711	36	,	,	PUNCT
admet-193	711	37	clotrimazole	clotrimazole	NOUN
admet-193	711	38	)	)	PUNCT
admet-193	711	39	,	,	PUNCT
admet-193	711	40	compared	compare	VERB
admet-193	711	41	to	to	ADP
admet-193	711	42	dmso	dmso	ADJ
admet-193	711	43	-	-	PUNCT
admet-193	711	44	free	free	ADJ
admet-193	711	45	conditions	condition	NOUN
admet-193	711	46	.	.	PUNCT
admet-193	712	1	this	this	PRON
admet-193	712	2	appears	appear	VERB
admet-193	712	3	to	to	PART
admet-193	712	4	be	be	AUX
admet-193	712	5	highly	highly	ADV
admet-193	712	6	compound	compound	NOUN
admet-193	712	7	-	-	PUNCT
admet-193	712	8	dependent	dependent	ADJ
admet-193	712	9	(	(	PUNCT
admet-193	712	10	chen	chen	PROPN
admet-193	712	11	et	et	PROPN
admet-193	712	12	al	al	PROPN
admet-193	712	13	.	.	PUNCT
admet-193	713	1	[	[	X
admet-193	713	2	58	58	NUM
admet-193	713	3	]	]	SYM
admet-193	713	4	)	)	PUNCT
admet-193	713	5	.	.	PUNCT
admet-193	714	1	quality	quality	NOUN
admet-193	714	2	results	result	NOUN
admet-193	714	3	require	require	VERB
admet-193	714	4	this	this	DET
admet-193	714	5	dmso	dmso	NOUN
admet-193	714	6	-	-	NOUN
admet-193	714	7	effect	effect	NOUN
admet-193	714	8	to	to	PART
admet-193	714	9	be	be	AUX
admet-193	714	10	factored	factor	VERB
admet-193	714	11	out	out	ADP
admet-193	714	12	(	(	PUNCT
admet-193	714	13	e.g.	e.g.	ADV
admet-193	714	14	,	,	PUNCT
admet-193	714	15	pdisol	pdisol	ADJ
admet-193	714	16	-	-	PUNCT
admet-193	714	17	x	x	SYM
admet-193	714	18	method	method	NOUN
admet-193	714	19	)	)	PUNCT
admet-193	714	20	.	.	PUNCT
admet-193	715	1	avdeef	avdeef	PROPN
admet-193	715	2	admet	admet	PROPN
admet-193	715	3	&	&	CCONJ
admet-193	715	4	dmpk	dmpk	PROPN
admet-193	715	5	3(2	3(2	NUM
admet-193	715	6	)	)	PUNCT
admet-193	715	7	(	(	PUNCT
admet-193	715	8	2015	2015	NUM
admet-193	715	9	)	)	PUNCT
admet-193	715	10	84	84	NUM
admet-193	715	11	-	-	SYM
admet-193	715	12	109	109	NUM
admet-193	715	13	106	106	NUM
admet-193	715	14	for	for	ADP
admet-193	715	15	acceptably	acceptably	ADV
admet-193	715	16	reliable	reliable	ADJ
admet-193	715	17	aqueous	aqueous	ADJ
admet-193	715	18	intrinsic	intrinsic	ADJ
admet-193	715	19	solubility	solubility	NOUN
admet-193	715	20	(	(	PUNCT
admet-193	715	21	s0	s0	PROPN
admet-193	715	22	)	)	PUNCT
admet-193	715	23	to	to	PART
admet-193	715	24	be	be	AUX
admet-193	715	25	determined	determine	VERB
admet-193	715	26	from	from	ADP
admet-193	715	27	single	single	ADJ
admet-193	715	28	-	-	PUNCT
admet-193	715	29	ph	ph	NOUN
admet-193	715	30	determination	determination	NOUN
admet-193	715	31	(	(	PUNCT
admet-193	715	32	of	of	ADP
admet-193	715	33	compounds	compound	NOUN
admet-193	715	34	introduced	introduce	VERB
admet-193	715	35	from	from	ADP
admet-193	715	36	dmso	dmso	ADJ
admet-193	715	37	stock	stock	NOUN
admet-193	715	38	solutions	solution	NOUN
admet-193	715	39	)	)	PUNCT
admet-193	715	40	,	,	PUNCT
admet-193	715	41	it	it	PRON
admet-193	715	42	is	be	AUX
admet-193	715	43	necessary	necessary	ADJ
admet-193	715	44	(	(	PUNCT
admet-193	715	45	a	a	NOUN
admet-193	715	46	)	)	PUNCT
admet-193	715	47	to	to	PART
admet-193	715	48	remove	remove	VERB
admet-193	715	49	the	the	DET
admet-193	715	50	dmso	dmso	NOUN
admet-193	715	51	originating	originate	VERB
admet-193	715	52	from	from	ADP
admet-193	715	53	the	the	DET
admet-193	715	54	stock	stock	NOUN
admet-193	715	55	solution	solution	NOUN
admet-193	715	56	,	,	PUNCT
admet-193	715	57	(	(	PUNCT
admet-193	715	58	b	b	X
admet-193	715	59	)	)	PUNCT
admet-193	715	60	to	to	PART
admet-193	715	61	know	know	VERB
admet-193	715	62	the	the	DET
admet-193	715	63	pka	pka	PROPN
admet-193	715	64	value	value	NOUN
admet-193	715	65	of	of	ADP
admet-193	715	66	the	the	DET
admet-193	715	67	test	test	NOUN
admet-193	715	68	compound	compound	NOUN
admet-193	715	69	,	,	PUNCT
admet-193	715	70	and	and	CCONJ
admet-193	715	71	(	(	PUNCT
admet-193	715	72	c	c	NOUN
admet-193	715	73	)	)	PUNCT
admet-193	715	74	to	to	PART
admet-193	715	75	assume	assume	VERB
admet-193	715	76	that	that	SCONJ
admet-193	715	77	the	the	DET
admet-193	715	78	henderson	henderson	PROPN
admet-193	715	79	-	-	PUNCT
admet-193	715	80	hasselbalch	hasselbalch	PROPN
admet-193	715	81	(	(	PUNCT
admet-193	715	82	hh	hh	NOUN
admet-193	715	83	)	)	PUNCT
admet-193	715	84	equation	equation	NOUN
admet-193	715	85	is	be	AUX
admet-193	715	86	a	a	DET
admet-193	715	87	valid	valid	ADJ
admet-193	715	88	description	description	NOUN
admet-193	715	89	of	of	ADP
admet-193	715	90	the	the	DET
admet-193	715	91	log	log	NOUN
admet-193	715	92	s	s	NOUN
admet-193	715	93	ph	ph	NOUN
admet-193	715	94	relationship	relationship	NOUN
admet-193	715	95	.	.	PUNCT
admet-193	716	1	if	if	SCONJ
admet-193	716	2	the	the	DET
admet-193	716	3	measurement	measurement	NOUN
admet-193	716	4	is	be	AUX
admet-193	716	5	performed	perform	VERB
admet-193	716	6	in	in	ADP
admet-193	716	7	the	the	DET
admet-193	716	8	presence	presence	NOUN
admet-193	716	9	of	of	ADP
admet-193	716	10	≤1	≤1	PROPN
admet-193	716	11	%	%	NOUN
admet-193	716	12	v	v	ADP
admet-193	716	13	/	/	SYM
admet-193	716	14	v	v	NOUN
admet-193	716	15	dmso	dmso	NOUN
admet-193	716	16	,	,	PUNCT
admet-193	716	17	there	there	PRON
admet-193	716	18	is	be	VERB
admet-193	716	19	a	a	DET
admet-193	716	20	way	way	NOUN
admet-193	716	21	to	to	PART
admet-193	716	22	determine	determine	VERB
admet-193	716	23	s0	s0	PROPN
admet-193	716	24	,	,	PUNCT
admet-193	716	25	provided	provide	VERB
admet-193	716	26	that	that	SCONJ
admet-193	716	27	the	the	DET
admet-193	716	28	solubility	solubility	NOUN
admet-193	716	29	measurement	measurement	NOUN
admet-193	716	30	is	be	AUX
admet-193	716	31	done	do	VERB
admet-193	716	32	at	at	ADP
admet-193	716	33	several	several	ADJ
admet-193	716	34	values	value	NOUN
admet-193	716	35	of	of	ADP
admet-193	716	36	ph	ph	NOUN
admet-193	716	37	over	over	ADP
admet-193	716	38	a	a	DET
admet-193	716	39	wide	wide	ADJ
admet-193	716	40	enough	enough	ADV
admet-193	716	41	a	a	DET
admet-193	716	42	ph	ph	ADJ
admet-193	716	43	range	range	NOUN
admet-193	716	44	(	(	PUNCT
admet-193	716	45	[	[	X
admet-193	716	46	52	52	NUM
admet-193	716	47	]	]	PUNCT
admet-193	716	48	;	;	PUNCT
admet-193	716	49	pdisol	pdisol	X
admet-193	716	50	-	-	PUNCT
admet-193	716	51	x	x	SYM
admet-193	716	52	method	method	NOUN
admet-193	716	53	)	)	PUNCT
admet-193	716	54	.	.	PUNCT
admet-193	717	1	if	if	SCONJ
admet-193	717	2	the	the	DET
admet-193	717	3	pka	pka	PROPN
admet-193	717	4	is	be	AUX
admet-193	717	5	known	know	VERB
admet-193	717	6	,	,	PUNCT
admet-193	717	7	then	then	ADV
admet-193	717	8	it	it	PRON
admet-193	717	9	is	be	AUX
admet-193	717	10	not	not	PART
admet-193	717	11	necessary	necessary	ADJ
admet-193	717	12	to	to	PART
admet-193	717	13	assume	assume	VERB
admet-193	717	14	that	that	SCONJ
admet-193	717	15	the	the	DET
admet-193	717	16	hh	hh	PROPN
admet-193	717	17	equation	equation	NOUN
admet-193	717	18	holds	hold	VERB
admet-193	717	19	,	,	PUNCT
admet-193	717	20	as	as	SCONJ
admet-193	717	21	has	have	AUX
admet-193	717	22	been	be	AUX
admet-193	717	23	demonstrated	demonstrate	VERB
admet-193	717	24	by	by	ADP
admet-193	717	25	avdeef	avdeef	PROPN
admet-193	717	26	et	et	PROPN
admet-193	717	27	al	al	PROPN
admet-193	717	28	.	.	PUNCT
admet-193	718	1	[	[	X
admet-193	718	2	74	74	NUM
admet-193	718	3	]	]	PUNCT
admet-193	718	4	.	.	PUNCT
admet-193	718	5	lyophilization	lyophilization	NOUN
admet-193	718	6	method	method	NOUN
admet-193	718	7	(	(	PUNCT
admet-193	718	8	‘	'	PUNCT
admet-193	718	9	genevac	genevac	NOUN
admet-193	718	10	’	'	PUNCT
admet-193	718	11	96	96	NUM
admet-193	718	12	-	-	PUNCT
admet-193	718	13	well	well	NOUN
admet-193	718	14	dmso	dmso	NOUN
admet-193	718	15	-	-	PUNCT
admet-193	718	16	removing	remove	VERB
admet-193	718	17	device	device	NOUN
admet-193	718	18	)	)	PUNCT
admet-193	718	19	some	some	DET
admet-193	718	20	pharmaceutical	pharmaceutical	ADJ
admet-193	718	21	companies	company	NOUN
admet-193	718	22	have	have	AUX
admet-193	718	23	implemented	implement	VERB
admet-193	718	24	methods	method	NOUN
admet-193	718	25	where	where	SCONJ
admet-193	718	26	aliquots	aliquot	NOUN
admet-193	718	27	of	of	ADP
admet-193	718	28	10	10	NUM
admet-193	718	29	mm	mm	PROPN
admet-193	718	30	dmso	dmso	NOUN
admet-193	718	31	stock	stock	NOUN
admet-193	718	32	solutions	solution	NOUN
admet-193	718	33	of	of	ADP
admet-193	718	34	test	test	NOUN
admet-193	718	35	compounds	compound	NOUN
admet-193	718	36	are	be	AUX
admet-193	718	37	added	add	VERB
admet-193	718	38	to	to	ADP
admet-193	718	39	a	a	DET
admet-193	718	40	microtitre	microtitre	NOUN
admet-193	718	41	plate	plate	NOUN
admet-193	718	42	.	.	PUNCT
admet-193	719	1	then	then	ADV
admet-193	719	2	,	,	PUNCT
admet-193	719	3	the	the	DET
admet-193	719	4	dmso	dmso	NOUN
admet-193	719	5	is	be	AUX
admet-193	719	6	removed	remove	VERB
admet-193	719	7	by	by	ADP
admet-193	719	8	lyophilization	lyophilization	NOUN
admet-193	719	9	(	(	PUNCT
admet-193	719	10	e.g.	e.g.	ADV
admet-193	719	11	,	,	PUNCT
admet-193	719	12	using	use	VERB
admet-193	719	13	genevac	genevac	PROPN
admet-193	719	14	vacuum	vacuum	NOUN
admet-193	719	15	centrifugation	centrifugation	NOUN
admet-193	719	16	apparatus	apparatus	NOUN
admet-193	719	17	)	)	PUNCT
admet-193	719	18	,	,	PUNCT
admet-193	719	19	after	after	ADP
admet-193	719	20	which	which	PRON
admet-193	719	21	,	,	PUNCT
admet-193	719	22	a	a	DET
admet-193	719	23	ph	ph	NOUN
admet-193	719	24	6.5	6.5	NUM
admet-193	719	25	or	or	CCONJ
admet-193	719	26	7.4	7.4	NUM
admet-193	719	27	buffer	buffer	NOUN
admet-193	719	28	is	be	AUX
admet-193	719	29	added	add	VERB
admet-193	719	30	to	to	ADP
admet-193	719	31	the	the	DET
admet-193	719	32	compound	compound	NOUN
admet-193	719	33	residues	residue	NOUN
admet-193	719	34	in	in	ADP
admet-193	719	35	the	the	DET
admet-193	719	36	microtitre	microtitre	NOUN
admet-193	719	37	plate	plate	NOUN
admet-193	719	38	.	.	PUNCT
admet-193	720	1	the	the	DET
admet-193	720	2	plate	plate	NOUN
admet-193	720	3	is	be	AUX
admet-193	720	4	sealed	seal	VERB
admet-193	720	5	and	and	CCONJ
admet-193	720	6	allowed	allow	VERB
admet-193	720	7	to	to	PART
admet-193	720	8	incubate	incubate	VERB
admet-193	720	9	up	up	ADP
admet-193	720	10	to	to	PART
admet-193	720	11	24	24	NUM
admet-193	720	12	h	h	NOUN
admet-193	720	13	,	,	PUNCT
admet-193	720	14	usually	usually	ADV
admet-193	720	15	at	at	ADP
admet-193	720	16	room	room	NOUN
admet-193	720	17	temperature	temperature	NOUN
admet-193	720	18	,	,	PUNCT
admet-193	720	19	during	during	ADP
admet-193	720	20	which	which	DET
admet-193	720	21	time	time	NOUN
admet-193	720	22	the	the	DET
admet-193	720	23	plate	plate	NOUN
admet-193	720	24	may	may	AUX
admet-193	720	25	be	be	AUX
admet-193	720	26	shaken	shake	VERB
admet-193	720	27	.	.	PUNCT
admet-193	721	1	for	for	ADP
admet-193	721	2	best	good	ADJ
admet-193	721	3	results	result	NOUN
admet-193	721	4	,	,	PUNCT
admet-193	721	5	the	the	DET
admet-193	721	6	final	final	ADJ
admet-193	721	7	(	(	PUNCT
admet-193	721	8	equilibrium	equilibrium	NOUN
admet-193	721	9	)	)	PUNCT
admet-193	721	10	ph	ph	NOUN
admet-193	721	11	needs	need	NOUN
admet-193	721	12	to	to	PART
admet-193	721	13	be	be	AUX
admet-193	721	14	measured	measure	VERB
admet-193	721	15	.	.	PUNCT
admet-193	722	1	with	with	SCONJ
admet-193	722	2	the	the	DET
admet-193	722	3	initial	initial	ADJ
admet-193	722	4	dmso	dmso	NOUN
admet-193	722	5	removed	remove	VERB
admet-193	722	6	,	,	PUNCT
admet-193	722	7	measured	measure	VERB
admet-193	722	8	solubility	solubility	NOUN
admet-193	722	9	values	value	NOUN
admet-193	722	10	can	can	AUX
admet-193	722	11	match	match	VERB
admet-193	722	12	those	those	PRON
admet-193	722	13	obtained	obtain	VERB
admet-193	722	14	by	by	ADP
admet-193	722	15	the	the	DET
admet-193	722	16	traditional	traditional	ADJ
admet-193	722	17	sf	sf	NOUN
admet-193	722	18	method	method	NOUN
admet-193	722	19	.	.	PUNCT
admet-193	723	1	alsenz	alsenz	PROPN
admet-193	723	2	and	and	CCONJ
admet-193	723	3	kansy	kansy	VERB
admet-193	724	1	[	[	X
admet-193	724	2	75	75	NUM
admet-193	724	3	]	]	PUNCT
admet-193	724	4	described	describe	VERB
admet-193	724	5	the	the	DET
admet-193	724	6	lyophilization	lyophilization	NOUN
admet-193	724	7	solubility	solubility	NOUN
admet-193	724	8	assay	assay	VERB
admet-193	724	9	(	(	PUNCT
admet-193	724	10	lysa	lysa	PROPN
admet-193	724	11	)	)	PUNCT
admet-193	724	12	based	base	VERB
admet-193	724	13	on	on	ADP
admet-193	724	14	uv	uv	NOUN
admet-193	724	15	plate	plate	NOUN
admet-193	724	16	reader	reader	NOUN
admet-193	724	17	and	and	CCONJ
admet-193	724	18	hplc	hplc	NOUN
admet-193	724	19	methods	method	NOUN
admet-193	724	20	.	.	PUNCT
admet-193	725	1	equilibrium	equilibrium	NOUN
admet-193	725	2	solubility	solubility	NOUN
admet-193	725	3	assay	assay	VERB
admet-193	725	4	(	(	PUNCT
admet-193	725	5	dmso	dmso	VERB
admet-193	725	6	-	-	ADJ
admet-193	725	7	free	free	ADJ
admet-193	725	8	‘	'	PUNCT
admet-193	725	9	thesa	thesa	NOUN
admet-193	725	10	’	'	PUNCT
admet-193	725	11	method	method	NOUN
admet-193	725	12	)	)	PUNCT
admet-193	725	13	alsenz	alsenz	PROPN
admet-193	725	14	and	and	CCONJ
admet-193	725	15	kansy	kansy	VERB
admet-193	726	1	[	[	X
admet-193	726	2	75	75	NUM
admet-193	726	3	]	]	PUNCT
admet-193	726	4	also	also	ADV
admet-193	726	5	described	describe	VERB
admet-193	726	6	the	the	DET
admet-193	726	7	thermodynamic	thermodynamic	ADJ
admet-193	726	8	solubility	solubility	NOUN
admet-193	726	9	assay	assay	X
admet-193	726	10	(	(	PUNCT
admet-193	726	11	thesa	thesa	NOUN
admet-193	726	12	)	)	PUNCT
admet-193	726	13	microtitre	microtitre	PROPN
admet-193	726	14	plate	plate	NOUN
admet-193	726	15	method	method	NOUN
admet-193	726	16	where	where	SCONJ
admet-193	726	17	<	<	X
admet-193	726	18	1	1	NUM
admet-193	726	19	mg	mg	ADP
admet-193	726	20	of	of	ADP
admet-193	726	21	weighed	weigh	VERB
admet-193	726	22	solid	solid	ADJ
admet-193	726	23	sample	sample	NOUN
admet-193	726	24	is	be	AUX
admet-193	726	25	added	add	VERB
admet-193	726	26	a	a	DET
admet-193	726	27	ph	ph	ADJ
admet-193	726	28	6.5	6.5	NUM
admet-193	726	29	buffer	buffer	NOUN
admet-193	726	30	solution	solution	NOUN
admet-193	726	31	.	.	PUNCT
admet-193	727	1	the	the	DET
admet-193	727	2	suspensions	suspension	NOUN
admet-193	727	3	are	be	AUX
admet-193	727	4	stirred	stir	VERB
admet-193	727	5	for	for	ADP
admet-193	727	6	2	2	NUM
admet-193	727	7	h	h	NOUN
admet-193	727	8	and	and	CCONJ
admet-193	727	9	allowed	allow	VERB
admet-193	727	10	to	to	PART
admet-193	727	11	sit	sit	VERB
admet-193	727	12	for	for	ADP
admet-193	727	13	another	another	DET
admet-193	727	14	20	20	NUM
admet-193	727	15	h	h	NOUN
admet-193	727	16	,	,	PUNCT
admet-193	727	17	before	before	ADP
admet-193	727	18	filtration	filtration	NOUN
admet-193	727	19	.	.	PUNCT
admet-193	728	1	a	a	DET
admet-193	728	2	provision	provision	NOUN
admet-193	728	3	for	for	ADP
admet-193	728	4	reading	read	VERB
admet-193	728	5	the	the	DET
admet-193	728	6	final	final	ADJ
admet-193	728	7	ph	ph	NOUN
admet-193	728	8	is	be	AUX
admet-193	728	9	included	include	VERB
admet-193	728	10	in	in	ADP
admet-193	728	11	the	the	DET
admet-193	728	12	protocol	protocol	NOUN
admet-193	728	13	.	.	PUNCT
admet-193	729	1	the	the	DET
admet-193	729	2	advantage	advantage	NOUN
admet-193	729	3	of	of	ADP
admet-193	729	4	the	the	DET
admet-193	729	5	thesa	thesa	NOUN
admet-193	729	6	method	method	NOUN
admet-193	729	7	is	be	AUX
admet-193	729	8	that	that	SCONJ
admet-193	729	9	the	the	DET
admet-193	729	10	compound	compound	NOUN
admet-193	729	11	is	be	AUX
admet-193	729	12	introduced	introduce	VERB
admet-193	729	13	in	in	ADP
admet-193	729	14	the	the	DET
admet-193	729	15	original	original	ADJ
admet-193	729	16	solid	solid	ADJ
admet-193	729	17	state	state	NOUN
admet-193	729	18	.	.	PUNCT
admet-193	730	1	partially	partially	ADV
admet-193	730	2	-	-	PUNCT
admet-193	730	3	automated	automate	VERB
admet-193	730	4	solubility	solubility	NOUN
admet-193	730	5	screening	screening	NOUN
admet-193	730	6	(	(	PUNCT
admet-193	730	7	dmso	dmso	ADJ
admet-193	730	8	-	-	ADJ
admet-193	730	9	free	free	ADJ
admet-193	730	10	‘	'	PUNCT
admet-193	730	11	pass	pass	VERB
admet-193	730	12	’	'	PUNCT
admet-193	730	13	method	method	NOUN
admet-193	730	14	)	)	PUNCT
admet-193	730	15	alsenz	alsenz	PROPN
admet-193	730	16	et	et	PROPN
admet-193	730	17	al	al	PROPN
admet-193	730	18	.	.	PUNCT
admet-193	731	1	[	[	X
admet-193	731	2	76	76	NUM
admet-193	731	3	]	]	PUNCT
admet-193	731	4	described	describe	VERB
admet-193	731	5	the	the	DET
admet-193	731	6	microtitre	microtitre	PROPN
admet-193	731	7	plate	plate	NOUN
admet-193	731	8	partially	partially	ADV
admet-193	731	9	-	-	PUNCT
admet-193	731	10	automated	automate	VERB
admet-193	731	11	solubility	solubility	NOUN
admet-193	731	12	screening	screening	NOUN
admet-193	731	13	(	(	PUNCT
admet-193	731	14	pass	pass	NOUN
admet-193	731	15	)	)	PUNCT
admet-193	731	16	,	,	PUNCT
admet-193	731	17	where	where	SCONJ
admet-193	731	18	solid	solid	ADJ
admet-193	731	19	compounds	compound	NOUN
admet-193	731	20	(	(	PUNCT
admet-193	731	21	dmso	dmso	ADJ
admet-193	731	22	-	-	PUNCT
admet-193	731	23	free	free	ADJ
admet-193	731	24	)	)	PUNCT
admet-193	731	25	are	be	AUX
admet-193	731	26	suspended	suspend	VERB
admet-193	731	27	as	as	ADP
admet-193	731	28	slurries	slurry	NOUN
admet-193	731	29	in	in	ADP
admet-193	731	30	volatile	volatile	ADJ
admet-193	731	31	heptane	heptane	NOUN
admet-193	731	32	,	,	PUNCT
admet-193	731	33	sonicated	sonicate	VERB
admet-193	731	34	to	to	PART
admet-193	731	35	increase	increase	VERB
admet-193	731	36	fractionation	fractionation	NOUN
admet-193	731	37	and	and	CCONJ
admet-193	731	38	dispersion	dispersion	NOUN
admet-193	731	39	,	,	PUNCT
admet-193	731	40	and	and	CCONJ
admet-193	731	41	then	then	ADV
admet-193	731	42	dispensed	dispense	VERB
admet-193	731	43	quickly	quickly	ADV
admet-193	731	44	in	in	ADP
admet-193	731	45	small	small	ADJ
admet-193	731	46	aliquots	aliquot	NOUN
admet-193	731	47	into	into	ADP
admet-193	731	48	microtitre	microtitre	PROPN
admet-193	731	49	plate	plate	NOUN
admet-193	731	50	wells	wells	PROPN
admet-193	731	51	.	.	PUNCT
admet-193	732	1	from	from	ADP
admet-193	732	2	the	the	DET
admet-193	732	3	dispensed	dispense	VERB
admet-193	732	4	volume	volume	NOUN
admet-193	732	5	,	,	PUNCT
admet-193	732	6	the	the	DET
admet-193	732	7	weight	weight	NOUN
admet-193	732	8	of	of	ADP
admet-193	732	9	drug	drug	NOUN
admet-193	732	10	is	be	AUX
admet-193	732	11	calculated	calculate	VERB
admet-193	732	12	.	.	PUNCT
admet-193	733	1	the	the	DET
admet-193	733	2	advantage	advantage	NOUN
admet-193	733	3	of	of	ADP
admet-193	733	4	the	the	DET
admet-193	733	5	pass	pass	NOUN
admet-193	733	6	method	method	NOUN
admet-193	733	7	is	be	AUX
admet-193	733	8	that	that	SCONJ
admet-193	733	9	the	the	DET
admet-193	733	10	compound	compound	NOUN
admet-193	733	11	is	be	AUX
admet-193	733	12	introduced	introduce	VERB
admet-193	733	13	in	in	ADP
admet-193	733	14	the	the	DET
admet-193	733	15	original	original	ADJ
admet-193	733	16	solid	solid	ADJ
admet-193	733	17	state	state	NOUN
admet-193	733	18	.	.	PUNCT
admet-193	734	1	the	the	DET
admet-193	734	2	heptane	heptane	NOUN
admet-193	734	3	is	be	AUX
admet-193	734	4	allowed	allow	VERB
admet-193	734	5	to	to	PART
admet-193	734	6	evaporate	evaporate	VERB
admet-193	734	7	,	,	PUNCT
admet-193	734	8	before	before	SCONJ
admet-193	734	9	buffer	buffer	NOUN
admet-193	734	10	is	be	AUX
admet-193	734	11	added	add	VERB
admet-193	734	12	.	.	PUNCT
admet-193	735	1	this	this	DET
admet-193	735	2	procedure	procedure	NOUN
admet-193	735	3	inherently	inherently	ADV
admet-193	735	4	can	can	AUX
admet-193	735	5	be	be	AUX
admet-193	735	6	used	use	VERB
admet-193	735	7	to	to	PART
admet-193	735	8	assess	assess	VERB
admet-193	735	9	relatively	relatively	ADV
admet-193	735	10	high	high	ADJ
admet-193	735	11	solubility	solubility	NOUN
admet-193	735	12	(	(	PUNCT
admet-193	735	13	several	several	ADJ
admet-193	735	14	mg	mg	NOUN
admet-193	735	15	/	/	SYM
admet-193	735	16	ml	ml	NOUN
admet-193	735	17	)	)	PUNCT
admet-193	735	18	by	by	ADP
admet-193	735	19	a	a	DET
admet-193	735	20	microtitre	microtitre	NOUN
admet-193	735	21	plate	plate	NOUN
admet-193	735	22	method	method	NOUN
admet-193	735	23	.	.	PUNCT
admet-193	736	1	the	the	DET
admet-193	736	2	comparison	comparison	NOUN
admet-193	736	3	of	of	ADP
admet-193	736	4	pass	pass	NOUN
admet-193	736	5	solubility	solubility	NOUN
admet-193	736	6	values	value	NOUN
admet-193	736	7	to	to	ADP
admet-193	736	8	those	those	PRON
admet-193	736	9	from	from	ADP
admet-193	736	10	standard	standard	ADJ
admet-193	736	11	sf	sf	PROPN
admet-193	736	12	values	value	NOUN
admet-193	736	13	was	be	AUX
admet-193	736	14	good	good	ADJ
admet-193	736	15	.	.	PUNCT
admet-193	737	1	small	small	ADJ
admet-193	737	2	-	-	PUNCT
admet-193	737	3	scale	scale	NOUN
admet-193	737	4	shake	shake	NOUN
admet-193	737	5	-	-	PUNCT
admet-193	737	6	flask	flask	NOUN
admet-193	737	7	method	method	NOUN
admet-193	737	8	(	(	PUNCT
admet-193	737	9	ssf	ssf	NOUN
admet-193	737	10	)	)	PUNCT
admet-193	737	11	bergström	bergström	NOUN
admet-193	737	12	et	et	PROPN
admet-193	737	13	al	al	PROPN
admet-193	737	14	.	.	PUNCT
admet-193	738	1	[	[	X
admet-193	738	2	6	6	NUM
admet-193	738	3	]	]	PUNCT
admet-193	738	4	described	describe	VERB
admet-193	738	5	the	the	DET
admet-193	738	6	small	small	ADJ
admet-193	738	7	-	-	PUNCT
admet-193	738	8	scale	scale	NOUN
admet-193	738	9	shake	shake	NOUN
admet-193	738	10	-	-	PUNCT
admet-193	738	11	flask	flask	NOUN
admet-193	738	12	(	(	PUNCT
admet-193	738	13	ssf	ssf	NOUN
admet-193	738	14	)	)	PUNCT
admet-193	738	15	method	method	NOUN
admet-193	738	16	,	,	PUNCT
admet-193	738	17	where	where	SCONJ
admet-193	738	18	crystalline	crystalline	NOUN
admet-193	738	19	compounds	compound	NOUN
admet-193	738	20	were	be	AUX
admet-193	738	21	added	add	VERB
admet-193	738	22	to	to	ADP
admet-193	738	23	50	50	NUM
admet-193	738	24	-	-	SYM
admet-193	738	25	200	200	NUM
admet-193	738	26	μl	μl	ADP
admet-193	738	27	solutions	solution	NOUN
admet-193	738	28	whose	whose	DET
admet-193	738	29	ph	ph	NOUN
admet-193	738	30	was	be	AUX
admet-193	738	31	then	then	ADV
admet-193	738	32	adjusted	adjust	VERB
admet-193	738	33	to	to	ADP
admet-193	738	34	at	at	ADV
admet-193	738	35	least	least	ADV
admet-193	738	36	one	one	NUM
admet-193	738	37	ph	ph	NOUN
admet-193	738	38	below	below	ADP
admet-193	738	39	the	the	DET
admet-193	738	40	pka	pka	NOUN
admet-193	738	41	for	for	ADP
admet-193	738	42	acids	acid	NOUN
admet-193	738	43	and	and	CCONJ
admet-193	738	44	one	one	NUM
admet-193	738	45	ph	ph	NOUN
admet-193	738	46	above	above	ADP
admet-193	738	47	the	the	DET
admet-193	738	48	pka	pka	NOUN
admet-193	738	49	for	for	ADP
admet-193	738	50	bases	basis	NOUN
admet-193	738	51	,	,	PUNCT
admet-193	738	52	in	in	ADP
admet-193	738	53	an	an	DET
admet-193	738	54	effort	effort	NOUN
admet-193	738	55	to	to	PART
admet-193	738	56	measure	measure	VERB
admet-193	738	57	s0	s0	PROPN
admet-193	738	58	directly	directly	ADV
admet-193	738	59	.	.	PUNCT
admet-193	739	1	after	after	ADP
admet-193	739	2	24	24	NUM
admet-193	739	3	-	-	SYM
admet-193	739	4	72	72	NUM
admet-193	739	5	h	h	NOUN
admet-193	739	6	of	of	ADP
admet-193	739	7	stirring	stirring	NOUN
admet-193	739	8	,	,	PUNCT
admet-193	739	9	the	the	DET
admet-193	739	10	solutions	solution	NOUN
admet-193	739	11	were	be	AUX
admet-193	739	12	centrifuged	centrifuge	VERB
admet-193	739	13	to	to	PART
admet-193	739	14	separate	separate	VERB
admet-193	739	15	the	the	DET
admet-193	739	16	phases	phase	NOUN
admet-193	739	17	.	.	PUNCT
admet-193	740	1	seventeen	seventeen	NUM
admet-193	740	2	compounds	compound	NOUN
admet-193	740	3	were	be	AUX
admet-193	740	4	measured	measure	VERB
admet-193	740	5	(	(	PUNCT
admet-193	740	6	0.7	0.7	NUM
admet-193	740	7	ng	ng	NOUN
admet-193	740	8	/	/	SYM
admet-193	740	9	ml	ml	NOUN
admet-193	740	10	to	to	ADP
admet-193	740	11	6	6	NUM
admet-193	740	12	mg	mg	NOUN
admet-193	740	13	/	/	SYM
admet-193	740	14	ml	ml	NOUN
admet-193	740	15	)	)	PUNCT
admet-193	740	16	.	.	PUNCT
admet-193	741	1	expanding	expand	VERB
admet-193	741	2	the	the	DET
admet-193	741	3	ssf	ssf	NOUN
admet-193	741	4	approach	approach	NOUN
admet-193	741	5	,	,	PUNCT
admet-193	741	6	bergström	bergström	NOUN
admet-193	741	7	et	et	PROPN
admet-193	741	8	al	al	AUX
admet-193	741	9	.	.	PUNCT
admet-193	742	1	[	[	X
admet-193	742	2	77	77	NUM
admet-193	742	3	]	]	PUNCT
admet-193	742	4	further	far	ADV
admet-193	742	5	studied	study	VERB
admet-193	742	6	25	25	NUM
admet-193	742	7	bases	basis	NOUN
admet-193	742	8	over	over	ADP
admet-193	742	9	a	a	DET
admet-193	742	10	wide	wide	ADJ
admet-193	742	11	ph	ph	ADJ
admet-193	742	12	range	range	NOUN
admet-193	742	13	,	,	PUNCT
admet-193	742	14	using	use	VERB
admet-193	742	15	0.15	0.15	NUM
admet-193	742	16	m	m	NOUN
admet-193	742	17	phosphate	phosphate	ADJ
admet-193	742	18	buffer	buffer	NOUN
admet-193	742	19	adjusted	adjust	VERB
admet-193	742	20	with	with	ADP
admet-193	742	21	koh	koh	PROPN
admet-193	742	22	or	or	CCONJ
admet-193	742	23	h3po4	h3po4	NOUN
admet-193	742	24	.	.	PUNCT
admet-193	743	1	the	the	DET
admet-193	743	2	suspensions	suspension	NOUN
admet-193	743	3	were	be	AUX
admet-193	743	4	incubated	incubate	VERB
admet-193	743	5	for	for	ADP
admet-193	743	6	24	24	NUM
admet-193	743	7	h.	h.	PROPN
admet-193	743	8	phases	phase	NOUN
admet-193	743	9	were	be	AUX
admet-193	743	10	separated	separate	VERB
admet-193	743	11	by	by	ADP
admet-193	743	12	centrifugation	centrifugation	NOUN
admet-193	743	13	.	.	PUNCT
admet-193	744	1	an	an	DET
admet-193	744	2	in	in	ADP
admet-193	744	3	-	-	PUNCT
admet-193	744	4	depth	depth	NOUN
admet-193	744	5	analysis	analysis	NOUN
admet-193	744	6	of	of	ADP
admet-193	744	7	the	the	DET
admet-193	744	8	25	25	NUM
admet-193	744	9	bases	basis	NOUN
admet-193	744	10	has	have	AUX
admet-193	744	11	been	be	AUX
admet-193	744	12	recently	recently	ADV
admet-193	744	13	reported	report	VERB
admet-193	744	14	admet	admet	PROPN
admet-193	744	15	&	&	CCONJ
admet-193	744	16	dmpk	dmpk	PROPN
admet-193	744	17	3(2	3(2	NUM
admet-193	744	18	)	)	PUNCT
admet-193	744	19	(	(	PUNCT
admet-193	744	20	2015	2015	NUM
admet-193	744	21	)	)	PUNCT
admet-193	744	22	84	84	NUM
admet-193	744	23	-	-	SYM
admet-193	744	24	109	109	NUM
admet-193	744	25	equilibrium	equilibrium	NOUN
admet-193	744	26	solubility	solubility	NOUN
admet-193	744	27	measurements	measurement	NOUN
admet-193	744	28	improvements	improvement	NOUN
admet-193	744	29	doi	doi	NOUN
admet-193	744	30	:	:	PUNCT
admet-193	744	31	10.5599	10.5599	NUM
admet-193	744	32	/	/	SYM
admet-193	744	33	admet.3.2.193	admet.3.2.193	X
admet-193	745	1	107	107	NUM
admet-193	746	1	[	[	X
admet-193	746	2	34	34	NUM
admet-193	746	3	]	]	PUNCT
admet-193	746	4	,	,	PUNCT
admet-193	746	5	where	where	SCONJ
admet-193	746	6	it	it	PRON
admet-193	746	7	was	be	AUX
admet-193	746	8	tentatively	tentatively	ADV
admet-193	746	9	suggested	suggest	VERB
admet-193	746	10	that	that	SCONJ
admet-193	746	11	24	24	NUM
admet-193	746	12	h	h	NOUN
admet-193	746	13	may	may	AUX
admet-193	746	14	not	not	PART
admet-193	746	15	be	be	AUX
admet-193	746	16	sufficient	sufficient	ADJ
admet-193	746	17	equilibration	equilibration	NOUN
admet-193	746	18	time	time	NOUN
admet-193	746	19	for	for	ADP
admet-193	746	20	several	several	ADJ
admet-193	746	21	of	of	ADP
admet-193	746	22	the	the	DET
admet-193	746	23	sparingly	sparingly	ADV
admet-193	746	24	-	-	PUNCT
admet-193	746	25	soluble	soluble	ADJ
admet-193	746	26	bases	basis	NOUN
admet-193	746	27	studied	study	VERB
admet-193	746	28	.	.	PUNCT
admet-193	747	1	other	other	ADJ
admet-193	747	2	concerns	concern	NOUN
admet-193	747	3	about	about	ADP
admet-193	747	4	ph	ph	NOUN
admet-193	747	5	control	control	NOUN
admet-193	747	6	were	be	AUX
admet-193	747	7	raised	raise	VERB
admet-193	747	8	by	by	ADP
admet-193	747	9	völgyi	völgyi	NOUN
admet-193	747	10	et	et	PROPN
admet-193	747	11	al	al	PROPN
admet-193	747	12	.	.	PUNCT
admet-193	748	1	[	[	X
admet-193	748	2	82	82	NUM
admet-193	748	3	]	]	PUNCT
admet-193	748	4	.	.	PUNCT
admet-193	748	5	miniaturized	miniaturize	VERB
admet-193	748	6	shake	shake	NOUN
admet-193	748	7	-	-	PUNCT
admet-193	748	8	flask	flask	NOUN
admet-193	748	9	(	(	PUNCT
admet-193	748	10	msf	msf	NOUN
admet-193	748	11	)	)	PUNCT
admet-193	748	12	glomme	glomme	NOUN
admet-193	748	13	et	et	PROPN
admet-193	748	14	al	al	PROPN
admet-193	748	15	.	.	PUNCT
admet-193	749	1	[	[	X
admet-193	749	2	78	78	NUM
admet-193	749	3	]	]	PUNCT
admet-193	749	4	described	describe	VERB
admet-193	749	5	the	the	DET
admet-193	749	6	miniaturized	miniaturize	VERB
admet-193	749	7	shake	shake	NOUN
admet-193	749	8	-	-	PUNCT
admet-193	749	9	flask	flask	NOUN
admet-193	749	10	(	(	PUNCT
admet-193	749	11	msf	msf	NOUN
admet-193	749	12	)	)	PUNCT
admet-193	749	13	method	method	NOUN
admet-193	749	14	.	.	PUNCT
admet-193	750	1	the	the	DET
admet-193	750	2	sample	sample	NOUN
admet-193	750	3	is	be	AUX
admet-193	750	4	weighed	weigh	VERB
admet-193	750	5	(	(	PUNCT
admet-193	750	6	twice	twice	DET
admet-193	750	7	the	the	PRON
admet-193	750	8	in	in	ADP
admet-193	750	9	silico	silico	NOUN
admet-193	750	10	-	-	PUNCT
admet-193	750	11	estimated	estimate	VERB
admet-193	750	12	solubility	solubility	NOUN
admet-193	750	13	)	)	PUNCT
admet-193	750	14	directly	directly	ADV
admet-193	750	15	into	into	ADP
admet-193	750	16	the	the	DET
admet-193	750	17	whatman	whatman	NOUN
admet-193	750	18	uniprep	uniprep	PROPN
admet-193	750	19	filter	filter	NOUN
admet-193	750	20	chamber	chamber	PROPN
admet-193	750	21	,	,	PUNCT
admet-193	750	22	which	which	PRON
admet-193	750	23	is	be	AUX
admet-193	750	24	then	then	ADV
admet-193	750	25	filled	fill	VERB
admet-193	750	26	with	with	ADP
admet-193	750	27	2	2	NUM
admet-193	750	28	ml	ml	NOUN
admet-193	750	29	of	of	ADP
admet-193	750	30	buffer	buffer	NOUN
admet-193	750	31	solution	solution	NOUN
admet-193	750	32	.	.	PUNCT
admet-193	751	1	the	the	DET
admet-193	751	2	capped	cap	VERB
admet-193	751	3	chambers	chamber	NOUN
admet-193	751	4	are	be	AUX
admet-193	751	5	agitated	agitate	VERB
admet-193	751	6	for	for	ADP
admet-193	751	7	24	24	NUM
admet-193	751	8	h	h	NOUN
admet-193	751	9	at	at	ADP
admet-193	751	10	37	37	NUM
admet-193	751	11	°	°	NOUN
admet-193	751	12	c	c	NOUN
admet-193	751	13	.	.	PUNCT
admet-193	752	1	afterwards	afterwards	ADV
admet-193	752	2	,	,	PUNCT
admet-193	752	3	a	a	DET
admet-193	752	4	chambermated	chambermate	VERB
admet-193	752	5	plunger	plunger	NOUN
admet-193	752	6	equipped	equip	VERB
admet-193	752	7	with	with	ADP
admet-193	752	8	a	a	DET
admet-193	752	9	filter	filter	NOUN
admet-193	752	10	is	be	AUX
admet-193	752	11	pushed	push	VERB
admet-193	752	12	over	over	ADP
admet-193	752	13	the	the	DET
admet-193	752	14	sample	sample	NOUN
admet-193	752	15	solution	solution	NOUN
admet-193	752	16	to	to	PART
admet-193	752	17	separate	separate	VERB
admet-193	752	18	the	the	DET
admet-193	752	19	solid	solid	NOUN
admet-193	752	20	.	.	PUNCT
admet-193	753	1	the	the	DET
admet-193	753	2	final	final	ADJ
admet-193	753	3	ph	ph	NOUN
admet-193	753	4	is	be	AUX
admet-193	753	5	read	read	VERB
admet-193	753	6	at	at	ADP
admet-193	753	7	the	the	DET
admet-193	753	8	end	end	NOUN
admet-193	753	9	of	of	ADP
admet-193	753	10	the	the	DET
admet-193	753	11	equilibration	equilibration	NOUN
admet-193	753	12	period	period	NOUN
admet-193	753	13	.	.	PUNCT
admet-193	754	1	dual	dual	ADJ
admet-193	754	2	-	-	PUNCT
admet-193	754	3	phase	phase	NOUN
admet-193	754	4	potentiometric	potentiometric	ADJ
admet-193	754	5	methods	method	NOUN
admet-193	754	6	the	the	DET
admet-193	754	7	two	two	NUM
admet-193	754	8	related	relate	VERB
admet-193	754	9	potentiometric	potentiometric	ADJ
admet-193	754	10	methods	method	NOUN
admet-193	754	11	described	describe	VERB
admet-193	754	12	below	below	ADV
admet-193	754	13	are	be	AUX
admet-193	754	14	only	only	ADV
admet-193	754	15	suitable	suitable	ADJ
admet-193	754	16	for	for	ADP
admet-193	754	17	ionizable	ionizable	ADJ
admet-193	754	18	compounds	compound	NOUN
admet-193	754	19	,	,	PUNCT
admet-193	754	20	whose	whose	DET
admet-193	754	21	pka	pka	NOUN
admet-193	754	22	can	can	AUX
admet-193	754	23	be	be	AUX
admet-193	754	24	determined	determine	VERB
admet-193	754	25	in	in	ADP
admet-193	754	26	situ	situ	NOUN
admet-193	754	27	(	(	PUNCT
admet-193	754	28	dtt	dtt	NOUN
admet-193	754	29	)	)	PUNCT
admet-193	754	30	or	or	CCONJ
admet-193	754	31	need	need	VERB
admet-193	754	32	to	to	PART
admet-193	754	33	be	be	AUX
admet-193	754	34	determined	determine	VERB
admet-193	754	35	in	in	ADP
admet-193	754	36	a	a	DET
admet-193	754	37	separate	separate	ADJ
admet-193	754	38	method	method	NOUN
admet-193	754	39	(	(	PUNCT
admet-193	754	40	cheqsol	cheqsol	PROPN
admet-193	754	41	)	)	PUNCT
admet-193	754	42	.	.	PUNCT
admet-193	755	1	dissolution	dissolution	NOUN
admet-193	755	2	template	template	NOUN
admet-193	755	3	titration	titration	NOUN
admet-193	755	4	method	method	NOUN
admet-193	755	5	(	(	PUNCT
admet-193	755	6	dtt	dtt	PROPN
admet-193	755	7	)	)	PUNCT
admet-193	755	8	the	the	DET
admet-193	755	9	dissolution	dissolution	NOUN
admet-193	755	10	template	template	NOUN
admet-193	755	11	titration	titration	NOUN
admet-193	755	12	(	(	PUNCT
admet-193	755	13	dtt	dtt	NOUN
admet-193	755	14	)	)	PUNCT
admet-193	755	15	semi	semi	ADJ
admet-193	755	16	-	-	ADJ
admet-193	755	17	automated	automated	ADJ
admet-193	755	18	intrinsic	intrinsic	ADJ
admet-193	755	19	solubility	solubility	NOUN
admet-193	755	20	potentiometric	potentiometric	ADJ
admet-193	755	21	method	method	NOUN
admet-193	755	22	[	[	X
admet-193	755	23	43	43	NUM
admet-193	755	24	]	]	PUNCT
admet-193	755	25	takes	take	VERB
admet-193	755	26	the	the	DET
admet-193	755	27	estimated	estimate	VERB
admet-193	755	28	pka	pka	NOUN
admet-193	755	29	and	and	CCONJ
admet-193	755	30	the	the	DET
admet-193	755	31	octanol	octanol	NOUN
admet-193	755	32	/	/	SYM
admet-193	755	33	water	water	NOUN
admet-193	755	34	partition	partition	NOUN
admet-193	755	35	coefficient	coefficient	NOUN
admet-193	755	36	,	,	PUNCT
admet-193	755	37	log	log	PROPN
admet-193	755	38	poct	poct	NOUN
admet-193	755	39	,	,	PUNCT
admet-193	755	40	as	as	SCONJ
admet-193	755	41	input	input	NOUN
admet-193	755	42	parameters	parameter	NOUN
admet-193	755	43	to	to	PART
admet-193	755	44	predict	predict	VERB
admet-193	755	45	s0	s0	PROPN
admet-193	755	46	.	.	PUNCT
admet-193	756	1	the	the	DET
admet-193	756	2	dtt	dtt	NOUN
admet-193	756	3	procedure	procedure	NOUN
admet-193	756	4	then	then	ADV
admet-193	756	5	simulates	simulate	VERB
admet-193	756	6	the	the	DET
admet-193	756	7	entire	entire	ADJ
admet-193	756	8	titration	titration	NOUN
admet-193	756	9	curve	curve	NOUN
admet-193	756	10	before	before	ADP
admet-193	756	11	the	the	DET
admet-193	756	12	assay	assay	NOUN
admet-193	756	13	starts	start	NOUN
admet-193	756	14	.	.	PUNCT
admet-193	757	1	this	this	PRON
admet-193	757	2	defines	define	VERB
admet-193	757	3	a	a	DET
admet-193	757	4	“	"	PUNCT
admet-193	757	5	template	template	NOUN
admet-193	757	6	”	"	PUNCT
admet-193	757	7	for	for	ADP
admet-193	757	8	data	data	NOUN
admet-193	757	9	collection	collection	NOUN
admet-193	757	10	.	.	PUNCT
admet-193	758	1	titration	titration	NOUN
admet-193	758	2	is	be	AUX
admet-193	758	3	done	do	VERB
admet-193	758	4	in	in	ADP
admet-193	758	5	the	the	DET
admet-193	758	6	direction	direction	NOUN
admet-193	758	7	of	of	ADP
admet-193	758	8	increasing	increase	VERB
admet-193	758	9	dissolution	dissolution	NOUN
admet-193	758	10	,	,	PUNCT
admet-193	758	11	taking	take	VERB
admet-193	758	12	the	the	DET
admet-193	758	13	saturated	saturate	VERB
admet-193	758	14	solutions	solution	NOUN
admet-193	758	15	past	past	ADP
admet-193	758	16	the	the	DET
admet-193	758	17	point	point	NOUN
admet-193	758	18	of	of	ADP
admet-193	758	19	complete	complete	ADJ
admet-193	758	20	dissolution	dissolution	NOUN
admet-193	758	21	.	.	PUNCT
admet-193	759	1	the	the	DET
admet-193	759	2	noyes	noyes	PROPN
admet-193	759	3	-	-	PUNCT
admet-193	759	4	whitney	whitney	PROPN
admet-193	759	5	equation	equation	NOUN
admet-193	759	6	(	(	PUNCT
admet-193	759	7	eq	eq	NOUN
admet-193	759	8	.	.	NOUN
admet-193	759	9	5	5	NUM
admet-193	759	10	below	below	ADV
admet-193	759	11	)	)	PUNCT
admet-193	759	12	is	be	AUX
admet-193	759	13	used	use	VERB
admet-193	759	14	to	to	PART
admet-193	759	15	set	set	VERB
admet-193	759	16	the	the	DET
admet-193	759	17	pace	pace	NOUN
admet-193	759	18	of	of	ADP
admet-193	759	19	data	datum	NOUN
admet-193	759	20	collection	collection	NOUN
admet-193	759	21	.	.	PUNCT
admet-193	760	1	the	the	DET
admet-193	760	2	more	more	ADV
admet-193	760	3	insoluble	insoluble	ADJ
admet-193	760	4	the	the	DET
admet-193	760	5	compound	compound	NOUN
admet-193	760	6	is	be	AUX
admet-193	760	7	(	(	PUNCT
admet-193	760	8	based	base	VERB
admet-193	760	9	on	on	ADP
admet-193	760	10	the	the	DET
admet-193	760	11	template	template	NOUN
admet-193	760	12	)	)	PUNCT
admet-193	760	13	,	,	PUNCT
admet-193	760	14	the	the	PRON
admet-193	760	15	longer	long	ADV
admet-193	760	16	is	be	AUX
admet-193	760	17	the	the	DET
admet-193	760	18	assay	assay	ADJ
admet-193	760	19	time	time	NOUN
admet-193	760	20	(	(	PUNCT
admet-193	760	21	typically	typically	ADV
admet-193	760	22	,	,	PUNCT
admet-193	760	23	3	3	NUM
admet-193	760	24	10	10	NUM
admet-193	760	25	h	h	NOUN
admet-193	760	26	)	)	PUNCT
admet-193	760	27	.	.	PUNCT
admet-193	761	1	data	datum	NOUN
admet-193	761	2	are	be	AUX
admet-193	761	3	analyzed	analyze	VERB
admet-193	761	4	using	use	VERB
admet-193	761	5	bjerrum	bjerrum	NOUN
admet-193	761	6	plots	plot	NOUN
admet-193	761	7	:	:	PUNCT
admet-193	761	8	͞nh	͞nh	PUNCT
admet-193	761	9	,	,	PUNCT
admet-193	761	10	the	the	DET
admet-193	761	11	average	average	ADJ
admet-193	761	12	number	number	NOUN
admet-193	761	13	of	of	ADP
admet-193	761	14	bound	bind	VERB
admet-193	761	15	protons	proton	NOUN
admet-193	761	16	,	,	PUNCT
admet-193	761	17	versus	versus	X
admet-193	761	18	ph	ph	PROPN
admet-193	761	19	.	.	PROPN
admet-193	762	1	since	since	SCONJ
admet-193	762	2	it	it	PRON
admet-193	762	3	is	be	AUX
admet-193	762	4	known	know	VERB
admet-193	762	5	how	how	SCONJ
admet-193	762	6	much	much	ADJ
admet-193	762	7	strong	strong	ADJ
admet-193	762	8	acid	acid	NOUN
admet-193	762	9	,	,	PUNCT
admet-193	762	10	[	[	X
admet-193	762	11	hcl	hcl	X
admet-193	762	12	]	]	X
admet-193	762	13	,	,	PUNCT
admet-193	762	14	and	and	CCONJ
admet-193	762	15	strong	strong	ADJ
admet-193	762	16	base	base	NOUN
admet-193	762	17	,	,	PUNCT
admet-193	762	18	[	[	X
admet-193	762	19	koh	koh	X
admet-193	762	20	]	]	X
admet-193	762	21	,	,	PUNCT
admet-193	762	22	have	have	AUX
admet-193	762	23	been	be	AUX
admet-193	762	24	added	add	VERB
admet-193	762	25	to	to	ADP
admet-193	762	26	the	the	DET
admet-193	762	27	solution	solution	NOUN
admet-193	762	28	at	at	ADP
admet-193	762	29	any	any	DET
admet-193	762	30	point	point	NOUN
admet-193	762	31	and	and	CCONJ
admet-193	762	32	since	since	SCONJ
admet-193	762	33	it	it	PRON
admet-193	762	34	is	be	AUX
admet-193	762	35	known	know	VERB
admet-193	762	36	how	how	SCONJ
admet-193	762	37	many	many	ADJ
admet-193	762	38	dissociable	dissociable	ADJ
admet-193	762	39	protons	proton	NOUN
admet-193	762	40	,	,	PUNCT
admet-193	762	41	n	n	CCONJ
admet-193	762	42	,	,	PUNCT
admet-193	762	43	the	the	DET
admet-193	762	44	sample	sample	NOUN
admet-193	762	45	adds	add	VERB
admet-193	762	46	to	to	ADP
admet-193	762	47	the	the	DET
admet-193	762	48	solution	solution	NOUN
admet-193	762	49	,	,	PUNCT
admet-193	762	50	the	the	DET
admet-193	762	51	total	total	ADJ
admet-193	762	52	hydrogen	hydrogen	NOUN
admet-193	762	53	ion	ion	NOUN
admet-193	762	54	concentration	concentration	NOUN
admet-193	762	55	is	be	AUX
admet-193	762	56	defined	define	VERB
admet-193	762	57	.	.	PUNCT
admet-193	763	1	the	the	DET
admet-193	763	2	difference	difference	NOUN
admet-193	763	3	between	between	ADP
admet-193	763	4	the	the	DET
admet-193	763	5	latter	latter	ADJ
admet-193	763	6	and	and	CCONJ
admet-193	763	7	the	the	DET
admet-193	763	8	free	free	ADJ
admet-193	763	9	hydrogen	hydrogen	NOUN
admet-193	763	10	(	(	PUNCT
admet-193	763	11	ph	ph	ADJ
admet-193	763	12	electrode	electrode	NOUN
admet-193	763	13	reading	reading	NOUN
admet-193	763	14	)	)	PUNCT
admet-193	763	15	concentrations	concentration	NOUN
admet-193	763	16	is	be	AUX
admet-193	763	17	equal	equal	ADJ
admet-193	763	18	to	to	ADP
admet-193	763	19	the	the	DET
admet-193	763	20	concentration	concentration	NOUN
admet-193	763	21	of	of	ADP
admet-193	763	22	the	the	DET
admet-193	763	23	bound	bind	VERB
admet-193	763	24	hydrogen	hydrogen	NOUN
admet-193	763	25	,	,	PUNCT
admet-193	763	26	which	which	PRON
admet-193	763	27	,	,	PUNCT
admet-193	763	28	when	when	SCONJ
admet-193	763	29	divided	divide	VERB
admet-193	763	30	by	by	ADP
admet-193	763	31	the	the	DET
admet-193	763	32	sample	sample	NOUN
admet-193	763	33	concentration	concentration	NOUN
admet-193	763	34	,	,	PUNCT
admet-193	763	35	c	c	X
admet-193	763	36	,	,	PUNCT
admet-193	763	37	results	result	VERB
admet-193	763	38	in	in	ADP
admet-193	763	39	͞nh	͞nh	X
admet-193	763	40	=	=	SYM
admet-193	763	41	{	{	PUNCT
admet-193	764	1	[	[	X
admet-193	764	2	hcl	hcl	X
admet-193	764	3	]	]	X
admet-193	765	1	[	[	X
admet-193	765	2	koh	koh	X
admet-193	765	3	]	]	X
admet-193	765	4	+	+	CCONJ
admet-193	765	5	n	n	PRON
admet-193	765	6	c	c	NOUN
admet-193	766	1	[	[	X
admet-193	766	2	h+	h+	X
admet-193	766	3	]	]	X
admet-193	767	1	+	+	CCONJ
admet-193	768	1	[	[	X
admet-193	768	2	oh-	oh-	X
admet-193	768	3	]	]	X
admet-193	768	4	}	}	PUNCT
admet-193	768	5	/	/	SYM
admet-193	768	6	c.	c.	NOUN
admet-193	768	7	the	the	DET
admet-193	768	8	ph	ph	NOUN
admet-193	768	9	at	at	ADP
admet-193	768	10	half	half	ADJ
admet-193	768	11	-	-	PUNCT
admet-193	768	12	integral	integral	ADJ
admet-193	768	13	value	value	NOUN
admet-193	768	14	of	of	ADP
admet-193	768	15	͞nh	͞nh	PUNCT
admet-193	768	16	equals	equal	VERB
admet-193	768	17	pka	pka	PROPN
admet-193	768	18	app	app	PROPN
admet-193	768	19	,	,	PUNCT
admet-193	768	20	the	the	DET
admet-193	768	21	apparent	apparent	ADJ
admet-193	768	22	pka	pka	PROPN
admet-193	768	23	.	.	PUNCT
admet-193	769	1	the	the	DET
admet-193	769	2	presence	presence	NOUN
admet-193	769	3	of	of	ADP
admet-193	769	4	precipitate	precipitate	NOUN
admet-193	769	5	is	be	AUX
admet-193	769	6	indicated	indicate	VERB
admet-193	769	7	by	by	ADP
admet-193	769	8	the	the	DET
admet-193	769	9	pka	pka	PROPN
admet-193	769	10	app	app	NOUN
admet-193	769	11	shifting	shift	VERB
admet-193	769	12	to	to	ADP
admet-193	769	13	a	a	DET
admet-193	769	14	higher	high	ADJ
admet-193	769	15	value	value	NOUN
admet-193	769	16	for	for	ADP
admet-193	769	17	acids	acid	NOUN
admet-193	769	18	and	and	CCONJ
admet-193	769	19	to	to	ADP
admet-193	769	20	a	a	DET
admet-193	769	21	lower	low	ADJ
admet-193	769	22	value	value	NOUN
admet-193	769	23	for	for	ADP
admet-193	769	24	bases	basis	NOUN
admet-193	769	25	,	,	PUNCT
admet-193	769	26	compared	compare	VERB
admet-193	769	27	to	to	ADP
admet-193	769	28	the	the	DET
admet-193	769	29	true	true	ADJ
admet-193	769	30	pka	pka	PROPN
admet-193	769	31	.	.	PUNCT
admet-193	770	1	the	the	DET
admet-193	770	2	intrinsic	intrinsic	ADJ
admet-193	770	3	solubility	solubility	NOUN
admet-193	770	4	can	can	AUX
admet-193	770	5	be	be	AUX
admet-193	770	6	deduced	deduce	VERB
admet-193	770	7	by	by	ADP
admet-193	770	8	inspection	inspection	NOUN
admet-193	770	9	of	of	ADP
admet-193	770	10	the	the	DET
admet-193	770	11	curves	curve	NOUN
admet-193	770	12	and	and	CCONJ
admet-193	770	13	applying	apply	VERB
admet-193	770	14	the	the	DET
admet-193	770	15	relationship	relationship	NOUN
admet-193	770	16	log	log	NOUN
admet-193	770	17	s0	s0	PROPN
admet-193	770	18	=	=	SYM
admet-193	770	19	log(c/2	log(c/2	PROPN
admet-193	770	20	)	)	PUNCT
admet-193	770	21	-|	-|	PROPN
admet-193	770	22	pka	pka	PROPN
admet-193	770	23	app	app	PROPN
admet-193	770	24	pka	pka	PROPN
admet-193	770	25	|	|	NOUN
admet-193	770	26	.	.	PUNCT
admet-193	771	1	the	the	DET
admet-193	771	2	graphically	graphically	ADV
admet-193	771	3	-	-	PUNCT
admet-193	771	4	estimated	estimate	VERB
admet-193	771	5	constant	constant	ADJ
admet-193	771	6	is	be	AUX
admet-193	771	7	subsequently	subsequently	ADV
admet-193	771	8	refined	refine	VERB
admet-193	771	9	by	by	ADP
admet-193	771	10	a	a	DET
admet-193	771	11	massbalance	massbalance	NOUN
admet-193	771	12	weighted	weight	VERB
admet-193	771	13	nonlinear	nonlinear	ADJ
admet-193	771	14	regression	regression	NOUN
admet-193	771	15	procedure	procedure	NOUN
admet-193	771	16	,	,	PUNCT
admet-193	771	17	which	which	PRON
admet-193	771	18	does	do	AUX
admet-193	771	19	not	not	PART
admet-193	771	20	require	require	VERB
admet-193	771	21	that	that	SCONJ
admet-193	771	22	the	the	DET
admet-193	771	23	henderson	henderson	PROPN
admet-193	771	24	-	-	PUNCT
admet-193	771	25	hasselbalch	hasselbalch	PROPN
admet-193	771	26	relationship	relationship	NOUN
admet-193	771	27	be	be	AUX
admet-193	771	28	valid	valid	ADJ
admet-193	771	29	(	(	PUNCT
admet-193	771	30	although	although	ADV
admet-193	771	31	,	,	PUNCT
admet-193	771	32	often	often	ADV
admet-193	771	33	,	,	PUNCT
admet-193	771	34	it	it	PRON
admet-193	771	35	is	be	AUX
admet-193	771	36	assumed	assume	VERB
admet-193	771	37	to	to	PART
admet-193	771	38	be	be	AUX
admet-193	771	39	so	so	ADV
admet-193	771	40	)	)	PUNCT
admet-193	771	41	.	.	PUNCT
admet-193	772	1	the	the	DET
admet-193	772	2	pka	pka	PROPN
admet-193	772	3	can	can	AUX
admet-193	772	4	be	be	AUX
admet-193	772	5	determined	determine	VERB
admet-193	772	6	alongside	alongside	ADP
admet-193	772	7	intrinsic	intrinsic	ADJ
admet-193	772	8	solubility	solubility	NOUN
admet-193	772	9	.	.	PUNCT
admet-193	773	1	cheqsol	cheqsol	PROPN
admet-193	773	2	potentiometric	potentiometric	PROPN
admet-193	773	3	method	method	PROPN
admet-193	773	4	stuart	stuart	PROPN
admet-193	773	5	and	and	CCONJ
admet-193	773	6	box	box	PROPN
admet-193	774	1	[	[	X
admet-193	774	2	35	35	NUM
admet-193	774	3	]	]	PUNCT
admet-193	774	4	embraced	embrace	VERB
admet-193	774	5	the	the	DET
admet-193	774	6	͞nh	͞nh	NUM
admet-193	774	7	part	part	NOUN
admet-193	774	8	of	of	ADP
admet-193	774	9	the	the	DET
admet-193	774	10	dtt	dtt	NOUN
admet-193	774	11	method	method	NOUN
admet-193	774	12	and	and	CCONJ
admet-193	774	13	developed	develop	VERB
admet-193	774	14	a	a	DET
admet-193	774	15	valuable	valuable	ADJ
admet-193	774	16	novel	novel	ADJ
admet-193	774	17	way	way	NOUN
admet-193	774	18	to	to	PART
admet-193	774	19	speed	speed	VERB
admet-193	774	20	up	up	ADP
admet-193	774	21	the	the	DET
admet-193	774	22	time	time	NOUN
admet-193	774	23	to	to	PART
admet-193	774	24	reach	reach	VERB
admet-193	774	25	equilibration	equilibration	NOUN
admet-193	774	26	.	.	PUNCT
admet-193	775	1	focusing	focus	VERB
admet-193	775	2	on	on	ADP
admet-193	775	3	the	the	DET
admet-193	775	4	ph	ph	ADJ
admet-193	775	5	region	region	NOUN
admet-193	775	6	where	where	SCONJ
admet-193	775	7	͞nh	͞nh	PUNCT
admet-193	775	8	is	be	AUX
admet-193	775	9	expected	expect	VERB
admet-193	775	10	to	to	PART
admet-193	775	11	be	be	AUX
admet-193	775	12	near	near	ADP
admet-193	775	13	halfintegral	halfintegral	NOUN
admet-193	775	14	,	,	PUNCT
admet-193	775	15	the	the	DET
admet-193	775	16	cheqsol	cheqsol	ADJ
admet-193	775	17	instrument	instrument	NOUN
admet-193	775	18	quickly	quickly	ADV
admet-193	775	19	dissolves	dissolve	VERB
admet-193	775	20	the	the	DET
admet-193	775	21	solid	solid	NOUN
admet-193	775	22	by	by	ADP
admet-193	775	23	raising	raise	VERB
admet-193	775	24	the	the	DET
admet-193	775	25	ph	ph	NOUN
admet-193	775	26	for	for	ADP
admet-193	775	27	acids	acid	NOUN
admet-193	775	28	(	(	PUNCT
admet-193	775	29	e.g.	e.g.	ADV
admet-193	775	30	,	,	PUNCT
admet-193	775	31	to	to	ADP
admet-193	775	32	10	10	NUM
admet-193	775	33	-	-	SYM
admet-193	775	34	12	12	NUM
admet-193	775	35	)	)	PUNCT
admet-193	775	36	or	or	CCONJ
admet-193	775	37	lowering	lower	VERB
admet-193	775	38	the	the	DET
admet-193	775	39	ph	ph	NOUN
admet-193	775	40	for	for	ADP
admet-193	775	41	bases	basis	NOUN
admet-193	775	42	(	(	PUNCT
admet-193	775	43	e.g.	e.g.	ADV
admet-193	775	44	,	,	PUNCT
admet-193	775	45	to	to	ADP
admet-193	775	46	1	1	NUM
admet-193	775	47	-	-	SYM
admet-193	775	48	2	2	NUM
admet-193	775	49	)	)	PUNCT
admet-193	775	50	.	.	PUNCT
admet-193	776	1	afterwards	afterwards	ADV
admet-193	776	2	,	,	PUNCT
admet-193	776	3	the	the	DET
admet-193	776	4	original	original	ADJ
admet-193	776	5	ph	ph	NOUN
admet-193	776	6	is	be	AUX
admet-193	776	7	re	re	VERB
admet-193	776	8	-	-	VERB
admet-193	776	9	established	establish	VERB
admet-193	776	10	by	by	ADP
admet-193	776	11	adding	add	VERB
admet-193	776	12	acid	acid	NOUN
admet-193	776	13	/	/	SYM
admet-193	776	14	base	base	NOUN
admet-193	776	15	titrant	titrant	NOUN
admet-193	776	16	,	,	PUNCT
admet-193	776	17	whereupon	whereupon	ADV
admet-193	776	18	the	the	DET
admet-193	776	19	solid	solid	ADJ
admet-193	776	20	re	re	NOUN
admet-193	776	21	-	-	NOUN
admet-193	776	22	precipitates	precipitate	NOUN
admet-193	776	23	,	,	PUNCT
admet-193	776	24	possibly	possibly	ADV
admet-193	776	25	as	as	ADP
admet-193	776	26	an	an	DET
admet-193	776	27	amorphous	amorphous	ADJ
admet-193	776	28	phase	phase	NOUN
admet-193	776	29	.	.	PUNCT
admet-193	777	1	the	the	DET
admet-193	777	2	procedure	procedure	NOUN
admet-193	777	3	of	of	ADP
admet-193	777	4	dissolution	dissolution	NOUN
admet-193	777	5	-	-	PUNCT
admet-193	777	6	precipitation	precipitation	NOUN
admet-193	777	7	is	be	AUX
admet-193	777	8	cycled	cycle	VERB
admet-193	777	9	several	several	ADJ
admet-193	777	10	times	time	NOUN
admet-193	777	11	,	,	PUNCT
admet-193	777	12	from	from	ADP
admet-193	777	13	which	which	PRON
admet-193	777	14	the	the	DET
admet-193	777	15	ph	ph	NOUN
admet-193	777	16	corresponding	corresponding	NOUN
admet-193	777	17	to	to	ADP
admet-193	777	18	a	a	DET
admet-193	777	19	known	know	VERB
admet-193	777	20	value	value	NOUN
admet-193	777	21	of	of	ADP
admet-193	777	22	nh	nh	PROPN
admet-193	777	23	(	(	PUNCT
admet-193	777	24	near	near	ADP
admet-193	777	25	0.5	0.5	NUM
admet-193	777	26	)	)	PUNCT
admet-193	777	27	is	be	AUX
admet-193	777	28	determined	determine	VERB
admet-193	777	29	by	by	ADP
admet-193	777	30	interpolation	interpolation	NOUN
admet-193	777	31	.	.	PUNCT
admet-193	778	1	using	use	VERB
admet-193	778	2	the	the	DET
admet-193	778	3	ddt	ddt	PROPN
admet-193	778	4	nh	nh	PROPN
admet-193	778	5	relationships	relationship	NOUN
admet-193	778	6	,	,	PUNCT
admet-193	778	7	the	the	DET
admet-193	778	8	intrinsic	intrinsic	ADJ
admet-193	778	9	s0	s0	NOUN
admet-193	778	10	is	be	AUX
admet-193	778	11	calculated	calculate	VERB
admet-193	778	12	from	from	ADP
admet-193	778	13	avdeef	avdeef	PROPN
admet-193	778	14	admet	admet	PROPN
admet-193	778	15	&	&	CCONJ
admet-193	778	16	dmpk	dmpk	PROPN
admet-193	778	17	3(2	3(2	NUM
admet-193	778	18	)	)	PUNCT
admet-193	778	19	(	(	PUNCT
admet-193	778	20	2015	2015	NUM
admet-193	778	21	)	)	PUNCT
admet-193	778	22	84	84	NUM
admet-193	778	23	-	-	SYM
admet-193	778	24	109	109	NUM
admet-193	778	25	108	108	NUM
admet-193	778	26	a	a	DET
admet-193	778	27	single	single	ADJ
admet-193	778	28	ph	ph	NOUN
admet-193	778	29	point	point	NOUN
admet-193	778	30	,	,	PUNCT
admet-193	778	31	suggested	suggest	VERB
admet-193	778	32	by	by	ADP
admet-193	778	33	the	the	DET
admet-193	778	34	value	value	NOUN
admet-193	778	35	of	of	ADP
admet-193	778	36	the	the	DET
admet-193	778	37	pka	pka	PROPN
admet-193	778	38	.	.	PUNCT
admet-193	779	1	since	since	SCONJ
admet-193	779	2	the	the	DET
admet-193	779	3	method	method	NOUN
admet-193	779	4	is	be	AUX
admet-193	779	5	not	not	PART
admet-193	779	6	based	base	VERB
admet-193	779	7	on	on	ADP
admet-193	779	8	the	the	DET
admet-193	779	9	general	general	ADJ
admet-193	779	10	massbalance	massbalance	NOUN
admet-193	779	11	base	base	NOUN
admet-193	779	12	regression	regression	NOUN
admet-193	779	13	analysis	analysis	NOUN
admet-193	779	14	,	,	PUNCT
admet-193	779	15	cheqsol	cheqsol	NOUN
admet-193	779	16	implicitly	implicitly	ADV
admet-193	779	17	assumes	assume	VERB
admet-193	779	18	that	that	SCONJ
admet-193	779	19	the	the	DET
admet-193	779	20	henderson	henderson	PROPN
admet-193	779	21	-	-	PUNCT
admet-193	779	22	hasselbalch	hasselbalch	PROPN
admet-193	779	23	equation	equation	NOUN
admet-193	779	24	is	be	AUX
admet-193	779	25	always	always	ADV
admet-193	779	26	valid	valid	ADJ
admet-193	779	27	,	,	PUNCT
admet-193	779	28	which	which	PRON
admet-193	779	29	in	in	ADP
admet-193	779	30	some	some	DET
admet-193	779	31	cases	case	NOUN
admet-193	779	32	could	could	AUX
admet-193	779	33	potentially	potentially	ADV
admet-193	779	34	be	be	AUX
admet-193	779	35	a	a	DET
admet-193	779	36	source	source	NOUN
admet-193	779	37	of	of	ADP
admet-193	779	38	systematic	systematic	ADJ
admet-193	779	39	error	error	NOUN
admet-193	779	40	.	.	PUNCT
admet-193	780	1	facilitated	facilitate	VERB
admet-193	780	2	dissolution	dissolution	NOUN
admet-193	780	3	method	method	NOUN
admet-193	780	4	(	(	PUNCT
admet-193	780	5	fdm	fdm	NOUN
admet-193	780	6	)	)	PUNCT
admet-193	780	7	the	the	DET
admet-193	780	8	facilitated	facilitate	VERB
admet-193	780	9	dissolution	dissolution	NOUN
admet-193	780	10	method	method	NOUN
admet-193	780	11	(	(	PUNCT
admet-193	780	12	fdm	fdm	NOUN
admet-193	780	13	)	)	PUNCT
admet-193	780	14	,	,	PUNCT
admet-193	780	15	devised	devise	VERB
admet-193	780	16	by	by	ADP
admet-193	780	17	higuchi	higuchi	PROPN
admet-193	780	18	et	et	PROPN
admet-193	780	19	al	al	PROPN
admet-193	780	20	.	.	PUNCT
admet-193	781	1	[	[	X
admet-193	781	2	79	79	NUM
admet-193	781	3	]	]	PUNCT
admet-193	781	4	,	,	PUNCT
admet-193	781	5	can	can	AUX
admet-193	781	6	be	be	AUX
admet-193	781	7	used	use	VERB
admet-193	781	8	to	to	PART
admet-193	781	9	overcome	overcome	VERB
admet-193	781	10	extremely	extremely	ADV
admet-193	781	11	low	low	ADJ
admet-193	781	12	equilibration	equilibration	NOUN
admet-193	781	13	rates	rate	NOUN
admet-193	781	14	during	during	ADP
admet-193	781	15	solubility	solubility	NOUN
admet-193	781	16	measurement	measurement	NOUN
admet-193	781	17	of	of	ADP
admet-193	781	18	practically	practically	ADV
admet-193	781	19	-	-	PUNCT
admet-193	781	20	insoluble	insoluble	ADJ
admet-193	781	21	compounds	compound	NOUN
admet-193	781	22	.	.	PUNCT
admet-193	782	1	since	since	SCONJ
admet-193	782	2	it	it	PRON
admet-193	782	3	is	be	AUX
admet-193	782	4	rarely	rarely	ADV
admet-193	782	5	practiced	practice	VERB
admet-193	782	6	,	,	PUNCT
admet-193	782	7	the	the	DET
admet-193	782	8	method	method	NOUN
admet-193	782	9	is	be	AUX
admet-193	782	10	described	describe	VERB
admet-193	782	11	here	here	ADV
admet-193	782	12	in	in	ADP
admet-193	782	13	some	some	DET
admet-193	782	14	detail	detail	NOUN
admet-193	782	15	(	(	PUNCT
admet-193	782	16	cf	cf	NOUN
admet-193	782	17	.	.	PUNCT
admet-193	782	18	,	,	PUNCT
admet-193	783	1	[	[	X
admet-193	783	2	52	52	NUM
admet-193	783	3	]	]	PUNCT
admet-193	783	4	)	)	PUNCT
admet-193	783	5	.	.	PUNCT
admet-193	784	1	in	in	ADP
admet-193	784	2	the	the	DET
admet-193	784	3	fdm	fdm	NOUN
admet-193	784	4	approach	approach	NOUN
admet-193	784	5	,	,	PUNCT
admet-193	784	6	a	a	DET
admet-193	784	7	twofold	twofold	ADJ
admet-193	784	8	excess	excess	NOUN
admet-193	784	9	of	of	ADP
admet-193	784	10	solid	solid	ADJ
admet-193	784	11	over	over	ADP
admet-193	784	12	that	that	PRON
admet-193	784	13	needed	need	VERB
admet-193	784	14	to	to	PART
admet-193	784	15	saturate	saturate	VERB
admet-193	784	16	the	the	DET
admet-193	784	17	solution	solution	NOUN
admet-193	784	18	is	be	AUX
admet-193	784	19	recommended	recommend	VERB
admet-193	784	20	.	.	PUNCT
admet-193	785	1	to	to	PART
admet-193	785	2	overcome	overcome	VERB
admet-193	785	3	the	the	DET
admet-193	785	4	expected	expect	VERB
admet-193	785	5	slow	slow	ADJ
admet-193	785	6	dissolution	dissolution	NOUN
admet-193	785	7	,	,	PUNCT
admet-193	785	8	a	a	DET
admet-193	785	9	small	small	ADJ
admet-193	785	10	volume	volume	NOUN
admet-193	785	11	of	of	ADP
admet-193	785	12	an	an	DET
admet-193	785	13	immiscible	immiscible	ADJ
admet-193	785	14	organic	organic	ADJ
admet-193	785	15	solvent	solvent	NOUN
admet-193	785	16	(	(	PUNCT
admet-193	785	17	e.g.	e.g.	ADV
admet-193	785	18	,	,	PUNCT
admet-193	785	19	2	2	NUM
admet-193	785	20	%	%	NOUN
admet-193	785	21	v	v	ADP
admet-193	785	22	/	/	SYM
admet-193	785	23	v	v	NOUN
admet-193	785	24	hexadecane	hexadecane	NOUN
admet-193	785	25	)	)	PUNCT
admet-193	785	26	is	be	AUX
admet-193	785	27	added	add	VERB
admet-193	785	28	to	to	ADP
admet-193	785	29	the	the	DET
admet-193	785	30	aqueous	aqueous	ADJ
admet-193	785	31	solution	solution	NOUN
admet-193	785	32	of	of	ADP
admet-193	785	33	the	the	DET
admet-193	785	34	sparingly	sparingly	ADV
admet-193	785	35	-	-	PUNCT
admet-193	785	36	soluble	soluble	ADJ
admet-193	785	37	compound	compound	NOUN
admet-193	785	38	.	.	PUNCT
admet-193	786	1	as	as	ADV
admet-193	786	2	long	long	ADV
admet-193	786	3	as	as	SCONJ
admet-193	786	4	the	the	DET
admet-193	786	5	saturated	saturate	VERB
admet-193	786	6	system	system	NOUN
admet-193	786	7	contains	contain	VERB
admet-193	786	8	three	three	NUM
admet-193	786	9	distinct	distinct	ADJ
admet-193	786	10	phases	phase	NOUN
admet-193	786	11	(	(	PUNCT
admet-193	786	12	solid	solid	ADJ
admet-193	786	13	,	,	PUNCT
admet-193	786	14	oil	oil	NOUN
admet-193	786	15	,	,	PUNCT
admet-193	786	16	and	and	CCONJ
admet-193	786	17	water	water	NOUN
admet-193	786	18	)	)	PUNCT
admet-193	786	19	,	,	PUNCT
admet-193	786	20	the	the	DET
admet-193	786	21	solubility	solubility	NOUN
admet-193	786	22	value	value	NOUN
admet-193	786	23	is	be	AUX
admet-193	786	24	not	not	PART
admet-193	786	25	altered	alter	VERB
admet-193	786	26	by	by	ADP
admet-193	786	27	the	the	DET
admet-193	786	28	presence	presence	NOUN
admet-193	786	29	of	of	ADP
admet-193	786	30	the	the	DET
admet-193	786	31	water	water	NOUN
admet-193	786	32	-	-	PUNCT
admet-193	786	33	immiscible	immiscible	ADJ
admet-193	786	34	oil	oil	NOUN
admet-193	786	35	.	.	PUNCT
admet-193	787	1	(	(	PUNCT
admet-193	787	2	this	this	PRON
admet-193	787	3	is	be	AUX
admet-193	787	4	sufficiently	sufficiently	ADV
admet-193	787	5	but	but	CCONJ
admet-193	787	6	not	not	PART
admet-193	787	7	precisely	precisely	ADV
admet-193	787	8	true	true	ADJ
admet-193	787	9	for	for	ADP
admet-193	787	10	ionizable	ionizable	ADJ
admet-193	787	11	compounds	compound	NOUN
admet-193	787	12	,	,	PUNCT
admet-193	787	13	as	as	SCONJ
admet-193	787	14	commented	comment	VERB
admet-193	787	15	below	below	ADP
admet-193	787	16	.	.	PUNCT
admet-193	787	17	)	)	PUNCT
admet-193	788	1	to	to	PART
admet-193	788	2	show	show	VERB
admet-193	788	3	this	this	PRON
admet-193	788	4	,	,	PUNCT
admet-193	788	5	consider	consider	VERB
admet-193	788	6	a	a	DET
admet-193	788	7	weak	weak	ADJ
admet-193	788	8	base	base	NOUN
admet-193	788	9	example	example	NOUN
admet-193	788	10	(	(	PUNCT
admet-193	788	11	e.g.	e.g.	ADJ
admet-193	788	12	,	,	PUNCT
admet-193	788	13	terfenadine	terfenadine	NOUN
admet-193	788	14	)	)	PUNCT
admet-193	788	15	,	,	PUNCT
admet-193	788	16	for	for	ADP
admet-193	788	17	which	which	PRON
admet-193	788	18	the	the	DET
admet-193	788	19	fdm	fdm	NOUN
admet-193	788	20	equilibrium	equilibrium	NOUN
admet-193	788	21	reactions	reaction	NOUN
admet-193	788	22	are	be	AUX
admet-193	788	23	:	:	PUNCT
admet-193	788	24	b(s	b(	NOUN
admet-193	788	25	)	)	PUNCT
admet-193	788	26	↔	↔	PROPN
admet-193	788	27	b(org	b(org	X
admet-193	788	28	)	)	PUNCT
admet-193	788	29	sorg	sorg	NOUN
admet-193	788	30	=	=	PROPN
admet-193	789	1	[	[	X
admet-193	789	2	b(org	b(org	X
admet-193	789	3	)	)	PUNCT
admet-193	789	4	]	]	PUNCT
admet-193	790	1	(	(	PUNCT
admet-193	790	2	2	2	X
admet-193	790	3	)	)	PUNCT
admet-193	790	4	b↔	b↔	ADV
admet-193	790	5	b(org	b(org	PROPN
admet-193	790	6	)	)	PUNCT
admet-193	790	7	po	po	NOUN
admet-193	790	8	/	/	SYM
admet-193	790	9	w	w	NOUN
admet-193	790	10	=	=	PUNCT
admet-193	791	1	[	[	X
admet-193	791	2	b(org	b(org	X
admet-193	791	3	)	)	PUNCT
admet-193	791	4	]	]	PUNCT
admet-193	791	5	/	/	PUNCT
admet-193	792	1	[	[	X
admet-193	792	2	b	b	X
admet-193	792	3	]	]	X
admet-193	792	4	(	(	PUNCT
admet-193	792	5	3	3	X
admet-193	792	6	)	)	PUNCT
admet-193	792	7	where	where	SCONJ
admet-193	792	8	eq	eq	NOUN
admet-193	792	9	.	.	NOUN
admet-193	792	10	2	2	NUM
admet-193	792	11	denotes	denote	VERB
admet-193	792	12	the	the	DET
admet-193	792	13	solubility	solubility	NOUN
admet-193	792	14	of	of	ADP
admet-193	792	15	the	the	DET
admet-193	792	16	compound	compound	NOUN
admet-193	792	17	in	in	ADP
admet-193	792	18	oil	oil	NOUN
admet-193	792	19	,	,	PUNCT
admet-193	792	20	sorg	sorg	NOUN
admet-193	792	21	,	,	PUNCT
admet-193	792	22	and	and	CCONJ
admet-193	792	23	eq	eq	NOUN
admet-193	792	24	.	.	NOUN
admet-193	792	25	3	3	NUM
admet-193	792	26	denotes	denote	VERB
admet-193	792	27	the	the	DET
admet-193	792	28	oil	oil	NOUN
admet-193	792	29	-	-	PUNCT
admet-193	792	30	water	water	NOUN
admet-193	792	31	partition	partition	NOUN
admet-193	792	32	coefficient	coefficient	NOUN
admet-193	792	33	of	of	ADP
admet-193	792	34	the	the	DET
admet-193	792	35	compound	compound	NOUN
admet-193	792	36	,	,	PUNCT
admet-193	792	37	po	po	NOUN
admet-193	792	38	/	/	SYM
admet-193	792	39	w.	w.	NOUN
admet-193	792	40	by	by	ADP
admet-193	792	41	subtracting	subtract	VERB
admet-193	792	42	the	the	DET
admet-193	792	43	partition	partition	NOUN
admet-193	792	44	reaction	reaction	NOUN
admet-193	792	45	from	from	ADP
admet-193	792	46	the	the	DET
admet-193	792	47	solubility	solubility	NOUN
admet-193	792	48	-	-	PUNCT
admet-193	792	49	in	in	ADP
admet-193	792	50	-	-	PUNCT
admet-193	792	51	oil	oil	NOUN
admet-193	792	52	reaction	reaction	NOUN
admet-193	792	53	,	,	PUNCT
admet-193	792	54	one	one	PRON
admet-193	792	55	gets	get	VERB
admet-193	792	56	the	the	DET
admet-193	792	57	expected	expect	VERB
admet-193	792	58	solubility	solubility	NOUN
admet-193	792	59	-	-	PUNCT
admet-193	792	60	in	in	ADP
admet-193	792	61	-	-	PUNCT
admet-193	792	62	water	water	NOUN
admet-193	792	63	equation	equation	NOUN
admet-193	792	64	,	,	PUNCT
admet-193	792	65	b(s	b(	NOUN
admet-193	792	66	)	)	PUNCT
admet-193	793	1	↔	↔	PROPN
admet-193	793	2	b	b	X
admet-193	793	3	sw	sw	PROPN
admet-193	793	4	=	=	SYM
admet-193	793	5	sorg	sorg	PROPN
admet-193	793	6	/	/	SYM
admet-193	793	7	po	po	PROPN
admet-193	793	8	/	/	SYM
admet-193	793	9	w	w	PROPN
admet-193	793	10	(	(	PUNCT
admet-193	793	11	4	4	NUM
admet-193	793	12	)	)	PUNCT
admet-193	793	13	so	so	ADV
admet-193	793	14	,	,	PUNCT
admet-193	793	15	the	the	DET
admet-193	793	16	presence	presence	NOUN
admet-193	793	17	of	of	ADP
admet-193	793	18	a	a	DET
admet-193	793	19	small	small	ADJ
admet-193	793	20	quantity	quantity	NOUN
admet-193	793	21	of	of	ADP
admet-193	793	22	oil	oil	NOUN
admet-193	793	23	,	,	PUNCT
admet-193	793	24	into	into	ADP
admet-193	793	25	which	which	PRON
admet-193	793	26	the	the	DET
admet-193	793	27	water	water	NOUN
admet-193	793	28	sparingly	sparingly	ADV
admet-193	793	29	-	-	PUNCT
admet-193	793	30	soluble	soluble	ADJ
admet-193	793	31	compound	compound	NOUN
admet-193	793	32	can	can	AUX
admet-193	793	33	appreciably	appreciably	ADV
admet-193	793	34	dissolve	dissolve	VERB
admet-193	793	35	,	,	PUNCT
admet-193	793	36	does	do	AUX
admet-193	793	37	not	not	PART
admet-193	793	38	affect	affect	VERB
admet-193	793	39	the	the	DET
admet-193	793	40	aqueous	aqueous	ADJ
admet-193	793	41	solubility	solubility	NOUN
admet-193	793	42	value	value	NOUN
admet-193	793	43	.	.	PUNCT
admet-193	794	1	according	accord	VERB
admet-193	794	2	to	to	ADP
admet-193	794	3	the	the	DET
admet-193	794	4	noyes	noyes	PROPN
admet-193	794	5	-	-	PUNCT
admet-193	794	6	whitney	whitney	PROPN
admet-193	794	7	dissolution	dissolution	PROPN
admet-193	794	8	rate	rate	NOUN
admet-193	794	9	(	(	PUNCT
admet-193	794	10	µg	µg	NOUN
admet-193	794	11	/	/	SYM
admet-193	794	12	cm3∙s	cm3∙	NOUN
admet-193	794	13	)	)	PUNCT
admet-193	794	14	equation	equation	NOUN
admet-193	794	15	under	under	ADP
admet-193	794	16	sink	sink	NOUN
admet-193	794	17	condition	condition	NOUN
admet-193	794	18	,	,	PUNCT
admet-193	794	19	d[b]/dt	d[b]/dt	X
admet-193	794	20	=	=	SYM
admet-193	794	21	(	(	PUNCT
admet-193	794	22	a	a	DET
admet-193	794	23	/	/	SYM
admet-193	794	24	v	v	NOUN
admet-193	794	25	)	)	PUNCT
admet-193	794	26	pabl	pabl	PROPN
admet-193	794	27	sw	sw	PROPN
admet-193	794	28	(	(	PUNCT
admet-193	794	29	5	5	NUM
admet-193	794	30	)	)	PUNCT
admet-193	794	31	where	where	SCONJ
admet-193	794	32	a	a	DET
admet-193	794	33	=	=	NOUN
admet-193	794	34	powder	powder	NOUN
admet-193	794	35	surface	surface	NOUN
admet-193	794	36	area	area	NOUN
admet-193	794	37	(	(	PUNCT
admet-193	794	38	cm2	cm2	NOUN
admet-193	794	39	)	)	PUNCT
admet-193	794	40	,	,	PUNCT
admet-193	794	41	v	v	X
admet-193	794	42	=	=	SYM
admet-193	794	43	volume	volume	NOUN
admet-193	794	44	of	of	ADP
admet-193	794	45	aqueous	aqueous	ADJ
admet-193	794	46	solution	solution	NOUN
admet-193	794	47	(	(	PUNCT
admet-193	794	48	cm3	cm3	NOUN
admet-193	794	49	)	)	PUNCT
admet-193	794	50	,	,	PUNCT
admet-193	794	51	pabl	pabl	NOUN
admet-193	794	52	=	=	SYM
admet-193	794	53	permeability	permeability	NOUN
admet-193	794	54	of	of	ADP
admet-193	794	55	the	the	DET
admet-193	794	56	aqueous	aqueous	ADJ
admet-193	794	57	boundary	boundary	ADJ
admet-193	794	58	layer	layer	NOUN
admet-193	794	59	adjacent	adjacent	ADJ
admet-193	794	60	to	to	ADP
admet-193	794	61	the	the	DET
admet-193	794	62	surface	surface	NOUN
admet-193	794	63	of	of	ADP
admet-193	794	64	the	the	DET
admet-193	794	65	solid	solid	ADJ
admet-193	794	66	particles	particle	NOUN
admet-193	794	67	(	(	PUNCT
admet-193	794	68	cm	cm	NOUN
admet-193	794	69	/	/	SYM
admet-193	794	70	s	s	NOUN
admet-193	794	71	)	)	PUNCT
admet-193	794	72	,	,	PUNCT
admet-193	794	73	and	and	CCONJ
admet-193	794	74	sw	sw	NOUN
admet-193	794	75	=	=	SYM
admet-193	794	76	aqueous	aqueous	ADJ
admet-193	794	77	solubility	solubility	NOUN
admet-193	794	78	(	(	PUNCT
admet-193	794	79	µg	µg	NOUN
admet-193	794	80	/	/	SYM
admet-193	794	81	cm3	cm3	NOUN
admet-193	794	82	)	)	PUNCT
admet-193	794	83	.	.	PUNCT
admet-193	795	1	the	the	DET
admet-193	795	2	addition	addition	NOUN
admet-193	795	3	of	of	ADP
admet-193	795	4	the	the	DET
admet-193	795	5	oil	oil	NOUN
admet-193	795	6	may	may	AUX
admet-193	795	7	also	also	ADV
admet-193	795	8	alleviate	alleviate	VERB
admet-193	795	9	problems	problem	NOUN
admet-193	795	10	due	due	ADJ
admet-193	795	11	to	to	ADP
admet-193	795	12	poor	poor	ADJ
admet-193	795	13	wettability	wettability	NOUN
admet-193	795	14	of	of	ADP
admet-193	795	15	the	the	DET
admet-193	795	16	original	original	ADJ
admet-193	795	17	crystalline	crystalline	NOUN
admet-193	795	18	solid	solid	NOUN
admet-193	795	19	.	.	PUNCT
admet-193	796	1	let	let	VERB
admet-193	796	2	's	us	PRON
admet-193	796	3	consider	consider	VERB
admet-193	796	4	the	the	DET
admet-193	796	5	terfenadine	terfenadine	NOUN
admet-193	796	6	fdm	fdm	PROPN
admet-193	796	7	example	example	NOUN
admet-193	796	8	explicitly	explicitly	ADV
admet-193	796	9	.	.	PUNCT
admet-193	797	1	the	the	DET
admet-193	797	2	intrinsic	intrinsic	ADJ
admet-193	797	3	solubility	solubility	NOUN
admet-193	797	4	of	of	ADP
admet-193	797	5	the	the	DET
admet-193	797	6	weak	weak	ADJ
admet-193	797	7	base	base	NOUN
admet-193	797	8	in	in	ADP
admet-193	797	9	water	water	NOUN
admet-193	797	10	is	be	AUX
admet-193	797	11	5.6x10	5.6x10	NUM
admet-193	797	12	-	-	SYM
admet-193	797	13	8	8	NUM
admet-193	797	14	m	m	NOUN
admet-193	797	15	(	(	PUNCT
admet-193	797	16	log	log	NOUN
admet-193	797	17	s0	s0	NOUN
admet-193	797	18	=	=	SYM
admet-193	797	19	-7.25	-7.25	PROPN
admet-193	797	20	)	)	PUNCT
admet-193	797	21	at	at	ADP
admet-193	797	22	25	25	NUM
admet-193	797	23	°	°	NOUN
admet-193	797	24	c	c	NOUN
admet-193	797	25	(	(	PUNCT
admet-193	797	26	streng	streng	PROPN
admet-193	797	27	et	et	PROPN
admet-193	797	28	al	al	PROPN
admet-193	797	29	.	.	PUNCT
admet-193	798	1	[	[	X
admet-193	798	2	80	80	NUM
admet-193	798	3	]	]	X
admet-193	798	4	;	;	PUNCT
admet-193	798	5	data	datum	NOUN
admet-193	798	6	analyzed	analyze	VERB
admet-193	798	7	using	use	VERB
admet-193	798	8	pdisol	pdisol	ADJ
admet-193	798	9	-	-	PUNCT
admet-193	798	10	x	x	NOUN
admet-193	798	11	)	)	PUNCT
admet-193	798	12	.	.	PUNCT
admet-193	799	1	the	the	DET
admet-193	799	2	measured	measured	ADJ
admet-193	799	3	pka	pka	PROPN
admet-193	799	4	is	be	AUX
admet-193	799	5	9.91	9.91	NUM
admet-193	799	6	at	at	ADP
admet-193	799	7	25	25	NUM
admet-193	799	8	°	°	NOUN
admet-193	799	9	c	c	NOUN
admet-193	799	10	,	,	PUNCT
admet-193	799	11	i	i	NOUN
admet-193	799	12	=	=	PROPN
admet-193	799	13	0.15	0.15	NUM
admet-193	799	14	m	m	NOUN
admet-193	799	15	(	(	PUNCT
admet-193	799	16	origin	origin	NOUN
admet-193	799	17	-	-	PUNCT
admet-193	799	18	shifted	shift	VERB
admet-193	799	19	yasuda	yasuda	NOUN
admet-193	799	20	-	-	PUNCT
admet-193	799	21	shedlovsky	shedlovsky	ADJ
admet-193	799	22	method	method	NOUN
admet-193	799	23	[	[	X
admet-193	799	24	52	52	NUM
admet-193	799	25	]	]	PUNCT
admet-193	799	26	)	)	PUNCT
admet-193	799	27	.	.	PUNCT
admet-193	800	1	consider	consider	VERB
admet-193	800	2	20	20	NUM
admet-193	800	3	μg	μg	PROPN
admet-193	800	4	of	of	ADP
admet-193	800	5	terfenadine	terfenadine	PROPN
admet-193	800	6	free	free	ADJ
admet-193	800	7	base	base	NOUN
admet-193	800	8	added	add	VERB
admet-193	800	9	to	to	ADP
admet-193	800	10	1	1	NUM
admet-193	800	11	ml	ml	NOUN
admet-193	800	12	of	of	ADP
admet-193	800	13	10	10	NUM
admet-193	800	14	mm	mm	NOUN
admet-193	800	15	taurine	taurine	ADJ
admet-193	800	16	buffer	buffer	NOUN
admet-193	800	17	in	in	ADP
admet-193	800	18	0.15	0.15	NUM
admet-193	800	19	m	m	NOUN
admet-193	800	20	nacl	nacl	NOUN
admet-193	800	21	at	at	ADP
admet-193	800	22	ph	ph	PROPN
admet-193	800	23	9.0	9.0	NUM
admet-193	800	24	,	,	PUNCT
admet-193	800	25	containing	contain	VERB
admet-193	800	26	20	20	NUM
admet-193	800	27	μl	μl	ADP
admet-193	800	28	of	of	ADP
admet-193	800	29	hexadecane	hexadecane	PROPN
admet-193	800	30	.	.	PUNCT
admet-193	801	1	let	let	VERB
admet-193	801	2	's	us	PRON
admet-193	801	3	assume	assume	VERB
admet-193	802	1	100	100	NUM
admet-193	802	2	μm	μm	NOUN
admet-193	802	3	(	(	PUNCT
admet-193	802	4	diam	diam	PROPN
admet-193	802	5	.	.	PUNCT
admet-193	802	6	)	)	PUNCT
admet-193	803	1	spherical	spherical	ADJ
admet-193	803	2	particles	particle	NOUN
admet-193	803	3	of	of	ADP
admet-193	803	4	solid	solid	ADJ
admet-193	803	5	in	in	ADP
admet-193	803	6	the	the	DET
admet-193	803	7	suspension	suspension	NOUN
admet-193	803	8	at	at	ADP
admet-193	803	9	the	the	DET
admet-193	803	10	start	start	NOUN
admet-193	803	11	.	.	PUNCT
admet-193	804	1	the	the	DET
admet-193	804	2	hexadecanewater	hexadecanewater	NOUN
admet-193	804	3	partition	partition	NOUN
admet-193	804	4	coefficient	coefficient	NOUN
admet-193	804	5	of	of	ADP
admet-193	804	6	terfenadine	terfenadine	NOUN
admet-193	804	7	is	be	AUX
admet-193	804	8	estimated	estimate	VERB
admet-193	804	9	to	to	PART
admet-193	804	10	be	be	AUX
admet-193	804	11	log	log	NOUN
admet-193	804	12	phxd	phxd	VERB
admet-193	804	13	/	/	SYM
admet-193	804	14	w	w	PROPN
admet-193	805	1	=	=	NOUN
admet-193	805	2	2.3	2.3	NUM
admet-193	805	3	(	(	PUNCT
admet-193	805	4	using	use	VERB
admet-193	805	5	calibration	calibration	NOUN
admet-193	805	6	standards	standard	NOUN
admet-193	805	7	from	from	ADP
admet-193	805	8	wohnsland	wohnsland	NOUN
admet-193	805	9	and	and	CCONJ
admet-193	805	10	faller	faller	NOUN
admet-193	805	11	[	[	X
admet-193	805	12	81	81	NUM
admet-193	805	13	]	]	PUNCT
admet-193	805	14	)	)	PUNCT
admet-193	805	15	.	.	PUNCT
admet-193	806	1	the	the	DET
admet-193	806	2	dissolution	dissolution	PROPN
admet-193	806	3	simulation	simulation	NOUN
admet-193	806	4	feature	feature	NOUN
admet-193	806	5	of	of	ADP
admet-193	806	6	pdisol	pdisol	NOUN
admet-193	806	7	-	-	PUNCT
admet-193	806	8	x	x	NOUN
admet-193	806	9	was	be	AUX
admet-193	806	10	used	use	VERB
admet-193	806	11	to	to	PART
admet-193	806	12	calculate	calculate	VERB
admet-193	806	13	the	the	DET
admet-193	806	14	precise	precise	ADJ
admet-193	806	15	concentrations	concentration	NOUN
admet-193	806	16	and	and	CCONJ
admet-193	806	17	quantities	quantity	NOUN
admet-193	806	18	in	in	ADP
admet-193	806	19	each	each	PRON
admet-193	806	20	of	of	ADP
admet-193	806	21	the	the	DET
admet-193	806	22	three	three	NUM
admet-193	806	23	phases	phase	NOUN
admet-193	806	24	.	.	PUNCT
admet-193	807	1	at	at	ADP
admet-193	807	2	ph	ph	PROPN
admet-193	807	3	9.0	9.0	NUM
admet-193	807	4	,	,	PUNCT
admet-193	807	5	0.302	0.302	NUM
admet-193	807	6	μg	μg	NOUN
admet-193	807	7	of	of	ADP
admet-193	807	8	the	the	DET
admet-193	807	9	drug	drug	NOUN
admet-193	807	10	is	be	AUX
admet-193	807	11	predicted	predict	VERB
admet-193	807	12	to	to	PART
admet-193	807	13	dissolve	dissolve	VERB
admet-193	807	14	in	in	ADP
admet-193	807	15	the	the	DET
admet-193	807	16	buffer	buffer	NOUN
admet-193	807	17	in	in	ADP
admet-193	807	18	the	the	DET
admet-193	807	19	absence	absence	NOUN
admet-193	807	20	of	of	ADP
admet-193	807	21	added	add	VERB
admet-193	807	22	hexadecane	hexadecane	NOUN
admet-193	807	23	,	,	PUNCT
admet-193	807	24	with	with	ADP
admet-193	807	25	19.70	19.70	NUM
admet-193	807	26	μg	μg	NUM
admet-193	807	27	remaining	remain	VERB
admet-193	807	28	in	in	ADP
admet-193	807	29	the	the	DET
admet-193	807	30	solid	solid	ADJ
admet-193	807	31	state	state	NOUN
admet-193	807	32	.	.	PUNCT
admet-193	808	1	the	the	DET
admet-193	808	2	calculated	calculate	VERB
admet-193	808	3	total	total	ADJ
admet-193	808	4	surface	surface	NOUN
admet-193	808	5	area	area	NOUN
admet-193	808	6	of	of	ADP
admet-193	808	7	the	the	DET
admet-193	808	8	solid	solid	NOUN
admet-193	808	9	is	be	AUX
admet-193	808	10	initially	initially	ADV
admet-193	808	11	0.0086	0.0086	NUM
admet-193	808	12	cm2	cm2	NOUN
admet-193	808	13	and	and	CCONJ
admet-193	808	14	decreases	decrease	NOUN
admet-193	808	15	by	by	ADP
admet-193	808	16	1.3	1.3	NUM
admet-193	808	17	%	%	NOUN
admet-193	808	18	at	at	ADP
admet-193	808	19	saturation	saturation	NOUN
admet-193	808	20	.	.	PUNCT
admet-193	809	1	the	the	DET
admet-193	809	2	(	(	PUNCT
admet-193	809	3	a	a	PRON
admet-193	809	4	/	/	SYM
admet-193	809	5	v	v	NOUN
admet-193	809	6	)	)	PUNCT
admet-193	809	7	factor	factor	NOUN
admet-193	809	8	for	for	ADP
admet-193	809	9	eq	eq	NOUN
admet-193	809	10	.	.	PROPN
admet-193	809	11	5	5	NUM
admet-193	809	12	is	be	AUX
admet-193	809	13	0.0086	0.0086	NUM
admet-193	809	14	cm-1	cm-1	NOUN
admet-193	809	15	.	.	PUNCT
admet-193	810	1	after	after	SCONJ
admet-193	810	2	the	the	DET
admet-193	810	3	addition	addition	NOUN
admet-193	810	4	of	of	ADP
admet-193	810	5	20	20	NUM
admet-193	810	6	μl	μl	ADP
admet-193	810	7	of	of	ADP
admet-193	810	8	hexadecane	hexadecane	PROPN
admet-193	810	9	,	,	PUNCT
admet-193	810	10	the	the	DET
admet-193	810	11	admet	admet	PROPN
admet-193	810	12	&	&	CCONJ
admet-193	810	13	dmpk	dmpk	PROPN
admet-193	810	14	3(2	3(2	NUM
admet-193	810	15	)	)	PUNCT
admet-193	810	16	(	(	PUNCT
admet-193	810	17	2015	2015	NUM
admet-193	810	18	)	)	PUNCT
admet-193	810	19	84	84	NUM
admet-193	810	20	-	-	SYM
admet-193	810	21	109	109	NUM
admet-193	810	22	equilibrium	equilibrium	NOUN
admet-193	810	23	solubility	solubility	NOUN
admet-193	810	24	measurements	measurement	NOUN
admet-193	810	25	improvements	improvement	NOUN
admet-193	810	26	doi	doi	NOUN
admet-193	810	27	:	:	PUNCT
admet-193	810	28	10.5599	10.5599	NUM
admet-193	810	29	/	/	SYM
admet-193	810	30	admet.3.2.193	admet.3.2.193	ADJ
admet-193	810	31	109	109	NUM
admet-193	810	32	calculated	calculate	VERB
admet-193	810	33	amount	amount	NOUN
admet-193	810	34	of	of	ADP
admet-193	810	35	the	the	DET
admet-193	810	36	drug	drug	NOUN
admet-193	810	37	in	in	ADP
admet-193	810	38	water	water	NOUN
admet-193	810	39	is	be	AUX
admet-193	810	40	still	still	ADV
admet-193	810	41	exactly	exactly	ADV
admet-193	810	42	0.302	0.302	NUM
admet-193	810	43	μg	μg	NOUN
admet-193	810	44	;	;	PUNCT
admet-193	810	45	the	the	DET
admet-193	810	46	amount	amount	NOUN
admet-193	810	47	in	in	ADP
admet-193	810	48	the	the	DET
admet-193	810	49	solid	solid	NOUN
admet-193	810	50	is	be	AUX
admet-193	810	51	now	now	ADV
admet-193	810	52	19.59	19.59	NUM
admet-193	810	53	μg	μg	NOUN
admet-193	810	54	,	,	PUNCT
admet-193	810	55	as	as	ADP
admet-193	810	56	0.20	0.20	NUM
admet-193	810	57	μg	μg	NOUN
admet-193	810	58	of	of	ADP
admet-193	810	59	the	the	DET
admet-193	810	60	drug	drug	NOUN
admet-193	810	61	partitions	partition	NOUN
admet-193	810	62	into	into	ADP
admet-193	810	63	the	the	DET
admet-193	810	64	20	20	NUM
admet-193	810	65	μl	μl	ADP
admet-193	810	66	of	of	ADP
admet-193	810	67	hexadecane	hexadecane	PROPN
admet-193	810	68	.	.	PUNCT
admet-193	811	1	the	the	DET
admet-193	811	2	solubility	solubility	NOUN
admet-193	811	3	in	in	ADP
admet-193	811	4	hexadecane	hexadecane	NOUN
admet-193	811	5	is	be	AUX
admet-193	811	6	calculated	calculate	VERB
admet-193	811	7	to	to	PART
admet-193	811	8	be	be	AUX
admet-193	811	9	2.2x10	2.2x10	NUM
admet-193	811	10	-7	-7	NOUN
admet-193	811	11	m	m	PROPN
admet-193	811	12	,	,	PUNCT
admet-193	811	13	compared	compare	VERB
admet-193	811	14	to	to	ADP
admet-193	811	15	6.4x10	6.4x10	NUM
admet-193	811	16	-7	-7	NOUN
admet-193	811	17	m	m	NOUN
admet-193	811	18	in	in	ADP
admet-193	811	19	the	the	DET
admet-193	811	20	buffer	buffer	NOUN
admet-193	811	21	.	.	PUNCT
admet-193	812	1	the	the	DET
admet-193	812	2	smaller	small	ADJ
admet-193	812	3	volume	volume	NOUN
admet-193	812	4	of	of	ADP
admet-193	812	5	the	the	DET
admet-193	812	6	oil	oil	NOUN
admet-193	812	7	phase	phase	NOUN
admet-193	812	8	increase	increase	VERB
admet-193	812	9	the	the	DET
admet-193	812	10	rate	rate	NOUN
admet-193	812	11	of	of	ADP
admet-193	812	12	dissolution	dissolution	NOUN
admet-193	812	13	into	into	ADP
admet-193	812	14	the	the	DET
admet-193	812	15	oil	oil	NOUN
admet-193	812	16	phase	phase	NOUN
admet-193	812	17	:	:	PUNCT
admet-193	812	18	the	the	DET
admet-193	812	19	(	(	PUNCT
admet-193	812	20	a	a	PRON
admet-193	812	21	/	/	SYM
admet-193	812	22	v	v	NOUN
admet-193	812	23	)	)	PUNCT
admet-193	812	24	factor	factor	NOUN
admet-193	812	25	between	between	ADP
admet-193	812	26	the	the	DET
admet-193	812	27	solid	solid	ADJ
admet-193	812	28	surface	surface	NOUN
admet-193	812	29	and	and	CCONJ
admet-193	812	30	the	the	DET
admet-193	812	31	oil	oil	NOUN
admet-193	812	32	volume	volume	NOUN
admet-193	812	33	is	be	AUX
admet-193	812	34	0.0086	0.0086	NUM
admet-193	812	35	cm	cm	NUM
admet-193	812	36	2	2	NUM
admet-193	812	37	/0.02	/0.02	SYM
admet-193	812	38	cm	cm	NOUN
admet-193	812	39	3	3	NUM
admet-193	812	40	=	=	SYM
admet-193	812	41	0.43	0.43	NUM
admet-193	812	42	cm	cm	NOUN
admet-193	812	43	-1	-1	INTJ
admet-193	812	44	.	.	PUNCT
admet-193	813	1	this	this	PRON
admet-193	813	2	suggests	suggest	VERB
admet-193	813	3	that	that	SCONJ
admet-193	813	4	the	the	DET
admet-193	813	5	rate	rate	NOUN
admet-193	813	6	of	of	ADP
admet-193	813	7	dissolution	dissolution	NOUN
admet-193	813	8	into	into	ADP
admet-193	813	9	the	the	DET
admet-193	813	10	oil	oil	NOUN
admet-193	813	11	phase	phase	NOUN
admet-193	813	12	will	will	AUX
admet-193	813	13	be	be	AUX
admet-193	813	14	about	about	ADV
admet-193	813	15	50	50	NUM
admet-193	813	16	times	time	NOUN
admet-193	813	17	greater	great	ADJ
admet-193	813	18	than	than	ADP
admet-193	813	19	the	the	DET
admet-193	813	20	rate	rate	NOUN
admet-193	813	21	of	of	ADP
admet-193	813	22	dissolution	dissolution	NOUN
admet-193	813	23	into	into	ADP
admet-193	813	24	the	the	DET
admet-193	813	25	water	water	NOUN
admet-193	813	26	phase	phase	NOUN
admet-193	813	27	.	.	PUNCT
admet-193	814	1	what	what	PRON
admet-193	814	2	about	about	ADP
admet-193	814	3	the	the	DET
admet-193	814	4	rate	rate	NOUN
admet-193	814	5	of	of	ADP
admet-193	814	6	transfer	transfer	NOUN
admet-193	814	7	from	from	ADP
admet-193	814	8	the	the	DET
admet-193	814	9	oil	oil	NOUN
admet-193	814	10	phase	phase	NOUN
admet-193	814	11	into	into	ADP
admet-193	814	12	water	water	NOUN
admet-193	814	13	(	(	PUNCT
admet-193	814	14	to	to	PART
admet-193	814	15	complete	complete	VERB
admet-193	814	16	the	the	DET
admet-193	814	17	transfer	transfer	NOUN
admet-193	814	18	cycle	cycle	NOUN
admet-193	814	19	in	in	ADP
admet-193	814	20	eq	eq	NOUN
admet-193	814	21	.	.	PROPN
admet-193	814	22	4	4	NUM
admet-193	814	23	)	)	PUNCT
admet-193	814	24	?	?	PUNCT
admet-193	815	1	this	this	PRON
admet-193	815	2	is	be	AUX
admet-193	815	3	expected	expect	VERB
admet-193	815	4	to	to	PART
admet-193	815	5	be	be	AUX
admet-193	815	6	high	high	ADJ
admet-193	815	7	in	in	ADP
admet-193	815	8	a	a	DET
admet-193	815	9	well	well	ADV
admet-193	815	10	stirred	stir	VERB
admet-193	815	11	(	(	PUNCT
admet-193	815	12	e.g.	e.g.	ADV
admet-193	815	13	,	,	PUNCT
admet-193	815	14	500	500	NUM
admet-193	815	15	rpm	rpm	NOUN
admet-193	815	16	)	)	PUNCT
admet-193	815	17	solution	solution	NOUN
admet-193	815	18	,	,	PUNCT
admet-193	815	19	dispersing	disperse	VERB
admet-193	815	20	the	the	DET
admet-193	815	21	oil	oil	NOUN
admet-193	815	22	into	into	ADP
admet-193	815	23	tiny	tiny	ADJ
admet-193	815	24	droplets	droplet	NOUN
admet-193	815	25	,	,	PUNCT
admet-193	815	26	thus	thus	ADV
admet-193	815	27	increasing	increase	VERB
admet-193	815	28	oil	oil	NOUN
admet-193	815	29	-	-	PUNCT
admet-193	815	30	water	water	NOUN
admet-193	815	31	interfacial	interfacial	ADJ
admet-193	815	32	surface	surface	NOUN
admet-193	815	33	area	area	NOUN
admet-193	815	34	.	.	PUNCT
admet-193	816	1	hence	hence	ADV
admet-193	816	2	,	,	PUNCT
admet-193	816	3	a	a	DET
admet-193	816	4	small	small	ADJ
admet-193	816	5	amount	amount	NOUN
admet-193	816	6	of	of	ADP
admet-193	816	7	adjunct	adjunct	ADJ
admet-193	816	8	oil	oil	NOUN
admet-193	816	9	substantially	substantially	ADV
admet-193	816	10	increases	increase	VERB
admet-193	816	11	the	the	DET
admet-193	816	12	overall	overall	ADJ
admet-193	816	13	dissolution	dissolution	NOUN
admet-193	816	14	rate	rate	NOUN
admet-193	816	15	associated	associate	VERB
admet-193	816	16	with	with	ADP
admet-193	816	17	eq	eq	PROPN
admet-193	816	18	.	.	PROPN
admet-193	816	19	5	5	NUM
admet-193	816	20	,	,	PUNCT
admet-193	816	21	without	without	ADP
admet-193	816	22	affecting	affect	VERB
admet-193	816	23	the	the	DET
admet-193	816	24	equilibrium	equilibrium	NOUN
admet-193	816	25	solubility	solubility	NOUN
admet-193	816	26	of	of	ADP
admet-193	816	27	terfenadine	terfenadine	NOUN
admet-193	816	28	.	.	PUNCT
admet-193	817	1	it	it	PRON
admet-193	817	2	is	be	AUX
admet-193	817	3	important	important	ADJ
admet-193	817	4	to	to	PART
admet-193	817	5	point	point	VERB
admet-193	817	6	out	out	ADP
admet-193	817	7	that	that	SCONJ
admet-193	817	8	the	the	DET
admet-193	817	9	fdm	fdm	NOUN
admet-193	817	10	approach	approach	NOUN
admet-193	817	11	does	do	AUX
admet-193	817	12	not	not	PART
admet-193	817	13	work	work	VERB
admet-193	817	14	for	for	ADP
admet-193	817	15	ionizable	ionizable	ADJ
admet-193	817	16	compounds	compound	NOUN
admet-193	817	17	in	in	ADP
admet-193	817	18	poorlybuffered	poorlybuffere	VERB
admet-193	817	19	solutions	solution	NOUN
admet-193	817	20	,	,	PUNCT
admet-193	817	21	and	and	CCONJ
admet-193	817	22	generally	generally	ADV
admet-193	817	23	can	can	AUX
admet-193	817	24	not	not	PART
admet-193	817	25	be	be	AUX
admet-193	817	26	applied	apply	VERB
admet-193	817	27	in	in	ADP
admet-193	817	28	the	the	DET
admet-193	817	29	dtt	dtt	NOUN
admet-193	817	30	or	or	CCONJ
admet-193	817	31	the	the	DET
admet-193	817	32	cheqsol	cheqsol	ADJ
admet-193	817	33	method	method	NOUN
admet-193	817	34	(	(	PUNCT
admet-193	817	35	since	since	SCONJ
admet-193	817	36	buffers	buffer	NOUN
admet-193	817	37	are	be	AUX
admet-193	817	38	not	not	PART
admet-193	817	39	generally	generally	ADV
admet-193	817	40	used	use	VERB
admet-193	817	41	)	)	PUNCT
admet-193	817	42	.	.	PUNCT
admet-193	818	1	using	use	VERB
admet-193	818	2	the	the	DET
admet-193	818	3	pdisol	pdisol	ADJ
admet-193	818	4	-	-	PUNCT
admet-193	818	5	x	x	NOUN
admet-193	818	6	program	program	NOUN
admet-193	818	7	,	,	PUNCT
admet-193	818	8	simulations	simulation	NOUN
admet-193	818	9	in	in	ADP
admet-193	818	10	buffer	buffer	NOUN
admet-193	818	11	-	-	PUNCT
admet-193	818	12	free	free	ADJ
admet-193	818	13	solutions	solution	NOUN
admet-193	818	14	show	show	VERB
admet-193	818	15	that	that	SCONJ
admet-193	818	16	the	the	DET
admet-193	818	17	addition	addition	NOUN
admet-193	818	18	of	of	ADP
admet-193	818	19	10	10	NUM
admet-193	818	20	μl	μl	INTJ
admet-193	818	21	hexadecane	hexadecane	NOUN
admet-193	818	22	can	can	AUX
admet-193	818	23	affect	affect	VERB
admet-193	818	24	the	the	DET
admet-193	818	25	water	water	NOUN
admet-193	818	26	solubility	solubility	NOUN
admet-193	818	27	of	of	ADP
admet-193	818	28	terfenadine	terfenadine	NOUN
admet-193	818	29	,	,	PUNCT
admet-193	818	30	through	through	ADP
admet-193	818	31	a	a	DET
admet-193	818	32	subtle	subtle	ADJ
admet-193	818	33	interplay	interplay	NOUN
admet-193	818	34	of	of	ADP
admet-193	818	35	the	the	DET
admet-193	818	36	various	various	ADJ
admet-193	818	37	ph	ph	ADJ
admet-193	818	38	-	-	ADJ
admet-193	818	39	dependent	dependent	ADJ
admet-193	818	40	equilibria	equilibrium	NOUN
admet-193	818	41	.	.	PUNCT
admet-193	819	1	the	the	DET
admet-193	819	2	effect	effect	NOUN
admet-193	819	3	is	be	AUX
admet-193	819	4	lessened	lessen	VERB
admet-193	819	5	if	if	SCONJ
admet-193	819	6	a	a	DET
admet-193	819	7	very	very	ADV
admet-193	819	8	large	large	ADJ
admet-193	819	9	excess	excess	NOUN
admet-193	819	10	of	of	ADP
admet-193	819	11	terfenadine	terfenadine	NOUN
admet-193	819	12	were	be	AUX
admet-193	819	13	added	add	VERB
admet-193	819	14	.	.	PUNCT
admet-193	820	1	but	but	CCONJ
admet-193	820	2	this	this	PRON
admet-193	820	3	is	be	AUX
admet-193	820	4	not	not	PART
admet-193	820	5	recommended	recommend	VERB
admet-193	820	6	,	,	PUNCT
admet-193	820	7	as	as	SCONJ
admet-193	820	8	discussed	discuss	VERB
admet-193	820	9	by	by	ADP
admet-193	820	10	higuchi	higuchi	PROPN
admet-193	820	11	et	et	PROPN
admet-193	820	12	al	al	PROPN
admet-193	820	13	.	.	PUNCT
admet-193	821	1	[	[	X
admet-193	821	2	79	79	NUM
admet-193	821	3	]	]	PUNCT
admet-193	821	4	.	.	PUNCT
admet-193	822	1	as	as	ADV
admet-193	822	2	far	far	ADV
admet-193	822	3	as	as	SCONJ
admet-193	822	4	we	we	PRON
admet-193	822	5	are	be	AUX
admet-193	822	6	aware	aware	ADJ
admet-193	822	7	,	,	PUNCT
admet-193	822	8	the	the	DET
admet-193	822	9	fdm	fdm	NOUN
admet-193	822	10	approach	approach	NOUN
admet-193	822	11	was	be	AUX
admet-193	822	12	last	last	ADV
admet-193	822	13	applied	apply	VERB
admet-193	822	14	by	by	ADP
admet-193	822	15	venkatesh	venkatesh	PROPN
admet-193	822	16	et	et	PROPN
admet-193	822	17	al	al	PROPN
admet-193	822	18	.	.	PUNCT
admet-193	823	1	[	[	X
admet-193	823	2	61	61	NUM
admet-193	823	3	]	]	PUNCT
admet-193	823	4	in	in	ADP
admet-193	823	5	the	the	DET
admet-193	823	6	solubility	solubility	NOUN
admet-193	823	7	determination	determination	NOUN
admet-193	823	8	of	of	ADP
admet-193	823	9	cosalane	cosalane	NOUN
admet-193	823	10	,	,	PUNCT
admet-193	823	11	a	a	DET
admet-193	823	12	steroid	steroid	NOUN
admet-193	823	13	derivative	derivative	NOUN
admet-193	823	14	with	with	ADP
admet-193	823	15	aqueous	aqueous	ADJ
admet-193	823	16	intrinsic	intrinsic	ADJ
admet-193	823	17	solubility	solubility	NOUN
admet-193	823	18	of	of	ADP
admet-193	823	19	much	much	ADV
admet-193	823	20	less	less	ADJ
admet-193	823	21	than	than	ADP
admet-193	823	22	1	1	NUM
admet-193	823	23	ng	ng	PROPN
admet-193	823	24	/	/	SYM
admet-193	823	25	ml	ml	PROPN
admet-193	823	26	.	.	PUNCT
admet-193	824	1	the	the	DET
admet-193	824	2	pka	pka	PROPN
admet-193	824	3	values	value	NOUN
admet-193	824	4	of	of	ADP
admet-193	824	5	cosalane	cosalane	NOUN
admet-193	824	6	have	have	AUX
admet-193	824	7	not	not	PART
admet-193	824	8	been	be	AUX
admet-193	824	9	reported	report	VERB
admet-193	824	10	to	to	ADP
admet-193	824	11	date	date	NOUN
admet-193	824	12	,	,	PUNCT
admet-193	824	13	so	so	SCONJ
admet-193	824	14	there	there	PRON
admet-193	824	15	may	may	AUX
admet-193	824	16	be	be	AUX
admet-193	824	17	some	some	DET
admet-193	824	18	uncertainty	uncertainty	NOUN
admet-193	824	19	in	in	ADP
admet-193	824	20	the	the	DET
admet-193	824	21	intrinsic	intrinsic	ADJ
admet-193	824	22	solubility	solubility	NOUN
admet-193	824	23	of	of	ADP
admet-193	824	24	cosalane	cosalane	NOUN
admet-193	824	25	.	.	PUNCT
admet-193	825	1	since	since	SCONJ
admet-193	825	2	the	the	DET
admet-193	825	3	fdm	fdm	NOUN
admet-193	825	4	method	method	NOUN
admet-193	825	5	is	be	AUX
admet-193	825	6	best	well	ADV
admet-193	825	7	applied	apply	VERB
admet-193	825	8	to	to	ADP
admet-193	825	9	practically	practically	ADV
admet-193	825	10	-	-	PUNCT
admet-193	825	11	insoluble	insoluble	ADJ
admet-193	825	12	molecules	molecule	NOUN
admet-193	825	13	,	,	PUNCT
admet-193	825	14	probably	probably	ADV
admet-193	825	15	lc	lc	PROPN
admet-193	825	16	/	/	SYM
admet-193	825	17	ms	ms	PROPN
admet-193	825	18	-	-	PUNCT
admet-193	825	19	ms	ms	PROPN
admet-193	825	20	resources	resource	NOUN
admet-193	825	21	would	would	AUX
admet-193	825	22	be	be	AUX
admet-193	825	23	required	require	VERB
admet-193	825	24	to	to	PART
admet-193	825	25	measure	measure	VERB
admet-193	825	26	the	the	DET
admet-193	825	27	extremely	extremely	ADV
admet-193	825	28	low	low	ADJ
admet-193	825	29	sample	sample	NOUN
admet-193	825	30	concentrations	concentration	NOUN
admet-193	825	31	in	in	ADP
admet-193	825	32	saturated	saturated	ADJ
admet-193	825	33	solutions	solution	NOUN
admet-193	825	34	.	.	PUNCT
admet-193	826	1	©	©	X
admet-193	826	2	2015	2015	NUM
admet-193	826	3	by	by	ADP
admet-193	826	4	the	the	DET
admet-193	826	5	authors	author	NOUN
admet-193	826	6	;	;	PUNCT
admet-193	826	7	licensee	licensee	PROPN
admet-193	826	8	iapc	iapc	PROPN
admet-193	826	9	,	,	PUNCT
admet-193	826	10	zagreb	zagreb	PROPN
admet-193	826	11	,	,	PUNCT
admet-193	826	12	croatia	croatia	PROPN
admet-193	826	13	.	.	PUNCT
admet-193	827	1	this	this	DET
admet-193	827	2	article	article	NOUN
admet-193	827	3	is	be	AUX
admet-193	827	4	an	an	DET
admet-193	827	5	open	open	ADJ
admet-193	827	6	-	-	PUNCT
admet-193	827	7	access	access	NOUN
admet-193	827	8	article	article	NOUN
admet-193	827	9	distributed	distribute	VERB
admet-193	827	10	under	under	ADP
admet-193	827	11	the	the	DET
admet-193	827	12	terms	term	NOUN
admet-193	827	13	and	and	CCONJ
admet-193	827	14	conditions	condition	NOUN
admet-193	827	15	of	of	ADP
admet-193	827	16	the	the	DET
admet-193	827	17	creative	creative	ADJ
admet-193	827	18	commons	common	NOUN
admet-193	827	19	attribution	attribution	NOUN
admet-193	827	20	license	license	NOUN
admet-193	827	21	(	(	PUNCT
admet-193	827	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-193	827	23	)	)	PUNCT
admet-193	827	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN