id	sid	tid	token	lemma	pos
admet-194	1	1	manuscript	manuscript	PROPN
admet-194	1	2	doi	doi	PROPN
admet-194	1	3	:	:	PUNCT
admet-194	1	4	10.5599	10.5599	NUM
admet-194	1	5	/	/	SYM
admet-194	1	6	admet.3.3.194	admet.3.3.194	PROPN
admet-194	1	7	216	216	NUM
admet-194	1	8	admet	admet	X
admet-194	1	9	&	&	CCONJ
admet-194	1	10	dmpk	dmpk	PROPN
admet-194	1	11	3(3	3(3	NUM
admet-194	1	12	)	)	PUNCT
admet-194	1	13	(	(	PUNCT
admet-194	1	14	2015	2015	NUM
admet-194	1	15	)	)	PUNCT
admet-194	1	16	216	216	NUM
admet-194	1	17	-	-	SYM
admet-194	1	18	234	234	NUM
admet-194	1	19	;	;	PUNCT
admet-194	1	20	doi	doi	NOUN
admet-194	1	21	:	:	PUNCT
admet-194	1	22	10.5599	10.5599	NUM
admet-194	1	23	/	/	SYM
admet-194	1	24	admet.3.3.194	admet.3.3.194	PROPN
admet-194	1	25	open	open	ADJ
admet-194	1	26	access	access	NOUN
admet-194	1	27	:	:	PUNCT
admet-194	1	28	issn	issn	PROPN
admet-194	1	29	:	:	PUNCT
admet-194	1	30	1848	1848	NUM
admet-194	1	31	-	-	SYM
admet-194	1	32	7718	7718	NUM
admet-194	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-194	1	34	review	review	NOUN
admet-194	1	35	chemical	chemical	NOUN
admet-194	1	36	and	and	CCONJ
admet-194	1	37	physical	physical	ADJ
admet-194	1	38	approaches	approach	NOUN
admet-194	1	39	for	for	ADP
admet-194	1	40	the	the	DET
admet-194	1	41	treatment	treatment	NOUN
admet-194	1	42	of	of	ADP
admet-194	1	43	alzheimer	alzheimer	PROPN
admet-194	1	44	's	's	PART
admet-194	1	45	disease	disease	NOUN
admet-194	1	46	jing	jing	PROPN
admet-194	1	47	li	li	PROPN
admet-194	1	48	,	,	PUNCT
admet-194	1	49	wei	wei	PROPN
admet-194	1	50	zhou	zhou	PROPN
admet-194	1	51	,	,	PUNCT
admet-194	1	52	xiaoli	xiaoli	PROPN
admet-194	1	53	wu	wu	PROPN
admet-194	1	54	and	and	CCONJ
admet-194	1	55	kin	kin	PROPN
admet-194	1	56	tam	tam	PROPN
admet-194	1	57	*	*	PROPN
admet-194	1	58	faculty	faculty	NOUN
admet-194	1	59	of	of	ADP
admet-194	1	60	health	health	NOUN
admet-194	1	61	sciences	sciences	PROPN
admet-194	1	62	,	,	PUNCT
admet-194	1	63	university	university	NOUN
admet-194	1	64	of	of	ADP
admet-194	1	65	macau	macau	PROPN
admet-194	1	66	,	,	PUNCT
admet-194	1	67	macau	macau	PROPN
admet-194	1	68	,	,	PUNCT
admet-194	1	69	china	china	PROPN
admet-194	1	70	*	*	PUNCT
admet-194	1	71	corresponding	correspond	VERB
admet-194	1	72	author	author	NOUN
admet-194	1	73	:	:	PUNCT
admet-194	1	74	e	e	NOUN
admet-194	1	75	-	-	NOUN
admet-194	1	76	mail	mail	NOUN
admet-194	1	77	:	:	PUNCT
admet-194	2	1	kintam@umac.mo	kintam@umac.mo	PROPN
admet-194	2	2	;	;	PUNCT
admet-194	2	3	tel	tel	PROPN
admet-194	2	4	.	.	PUNCT
admet-194	2	5	:	:	PUNCT
admet-194	2	6	+853	+853	NUM
admet-194	2	7	-	-	PUNCT
admet-194	2	8	8822	8822	NUM
admet-194	2	9	-	-	SYM
admet-194	2	10	4988	4988	NUM
admet-194	2	11	;	;	PUNCT
admet-194	2	12	fax	fax	NOUN
admet-194	2	13	:	:	PUNCT
admet-194	2	14	+853	+853	NOUN
admet-194	2	15	-	-	PUNCT
admet-194	2	16	8822	8822	NUM
admet-194	2	17	-	-	SYM
admet-194	2	18	2314	2314	NUM
admet-194	2	19	received	receive	VERB
admet-194	2	20	:	:	PUNCT
admet-194	2	21	june	june	PROPN
admet-194	2	22	18	18	NUM
admet-194	2	23	,	,	PUNCT
admet-194	2	24	2015	2015	NUM
admet-194	2	25	;	;	PUNCT
admet-194	2	26	revised	revise	VERB
admet-194	2	27	:	:	PUNCT
admet-194	2	28	august	august	PROPN
admet-194	2	29	20	20	NUM
admet-194	2	30	,	,	PUNCT
admet-194	2	31	2015	2015	NUM
admet-194	2	32	;	;	PUNCT
admet-194	2	33	published	publish	VERB
admet-194	2	34	:	:	PUNCT
admet-194	2	35	september	september	PROPN
admet-194	2	36	05	05	NUM
admet-194	2	37	,	,	PUNCT
admet-194	2	38	2015	2015	NUM
admet-194	2	39	abstract	abstract	PROPN
admet-194	2	40	alzheimer	alzheimer	PROPN
admet-194	2	41	’s	’s	PART
admet-194	2	42	disease	disease	NOUN
admet-194	2	43	(	(	PUNCT
admet-194	2	44	ad	ad	NOUN
admet-194	2	45	)	)	PUNCT
admet-194	2	46	is	be	AUX
admet-194	2	47	a	a	DET
admet-194	2	48	destructive	destructive	ADJ
admet-194	2	49	neurodegenerative	neurodegenerative	ADJ
admet-194	2	50	disorder	disorder	NOUN
admet-194	2	51	,	,	PUNCT
admet-194	2	52	which	which	PRON
admet-194	2	53	threatens	threaten	VERB
admet-194	2	54	elderly	elderly	ADJ
admet-194	2	55	people	people	NOUN
admet-194	2	56	in	in	ADP
admet-194	2	57	their	their	PRON
admet-194	2	58	mental	mental	ADJ
admet-194	2	59	health	health	NOUN
admet-194	2	60	irreversibly	irreversibly	ADV
admet-194	2	61	,	,	PUNCT
admet-194	2	62	causing	cause	VERB
admet-194	2	63	cognitive	cognitive	ADJ
admet-194	2	64	deficit	deficit	NOUN
admet-194	2	65	such	such	ADJ
admet-194	2	66	as	as	ADP
admet-194	2	67	learning	learn	VERB
admet-194	2	68	difficulties	difficulty	NOUN
admet-194	2	69	and	and	CCONJ
admet-194	2	70	memory	memory	NOUN
admet-194	2	71	loss	loss	NOUN
admet-194	2	72	.	.	PUNCT
admet-194	3	1	neurobiological	neurobiological	ADJ
admet-194	3	2	pathogenesis	pathogenesis	NOUN
admet-194	3	3	leading	lead	VERB
admet-194	3	4	to	to	ADP
admet-194	3	5	the	the	DET
admet-194	3	6	neuronal	neuronal	ADJ
admet-194	3	7	dysfunction	dysfunction	NOUN
admet-194	3	8	in	in	ADP
admet-194	3	9	ad	ad	NOUN
admet-194	3	10	are	be	AUX
admet-194	3	11	mainly	mainly	ADV
admet-194	3	12	rationalized	rationalize	VERB
admet-194	3	13	by	by	ADP
admet-194	3	14	two	two	NUM
admet-194	3	15	hypotheses	hypothesis	NOUN
admet-194	3	16	:	:	PUNCT
admet-194	3	17	1	1	NUM
admet-194	3	18	)	)	PUNCT
admet-194	3	19	extracellular	extracellular	ADJ
admet-194	3	20	aggregation	aggregation	NOUN
admet-194	3	21	of	of	ADP
admet-194	3	22	the	the	DET
admet-194	3	23	β	β	NOUN
admet-194	3	24	-	-	NOUN
admet-194	3	25	amyloid	amyloid	NOUN
admet-194	3	26	(	(	PUNCT
admet-194	3	27	aβ	aβ	NOUN
admet-194	3	28	)	)	PUNCT
admet-194	3	29	peptide	peptide	NOUN
admet-194	3	30	,	,	PUNCT
admet-194	3	31	which	which	PRON
admet-194	3	32	impacts	impact	VERB
admet-194	3	33	on	on	ADP
admet-194	3	34	the	the	DET
admet-194	3	35	normal	normal	ADJ
admet-194	3	36	neuronal	neuronal	ADJ
admet-194	3	37	pathways	pathway	NOUN
admet-194	3	38	through	through	ADP
admet-194	3	39	excessive	excessive	ADJ
admet-194	3	40	oxidative	oxidative	ADJ
admet-194	3	41	stress	stress	NOUN
admet-194	3	42	and	and	CCONJ
admet-194	3	43	damages	damage	NOUN
admet-194	3	44	neurons	neuron	NOUN
admet-194	3	45	;	;	PUNCT
admet-194	3	46	and	and	CCONJ
admet-194	3	47	2	2	X
admet-194	3	48	)	)	PUNCT
admet-194	3	49	intracellular	intracellular	ADJ
admet-194	3	50	hyperphosphorylation	hyperphosphorylation	NOUN
admet-194	3	51	of	of	ADP
admet-194	3	52	tau	tau	PROPN
admet-194	3	53	protein	protein	NOUN
admet-194	3	54	,	,	PUNCT
admet-194	3	55	which	which	PRON
admet-194	3	56	forms	form	VERB
admet-194	3	57	the	the	DET
admet-194	3	58	paired	pair	VERB
admet-194	3	59	helical	helical	ADJ
admet-194	3	60	filaments	filament	NOUN
admet-194	3	61	,	,	PUNCT
admet-194	3	62	then	then	ADV
admet-194	3	63	gravely	gravely	ADV
admet-194	3	64	impacts	impact	VERB
admet-194	3	65	axonal	axonal	ADJ
admet-194	3	66	transport	transport	NOUN
admet-194	3	67	.	.	PUNCT
admet-194	4	1	in	in	ADP
admet-194	4	2	this	this	DET
admet-194	4	3	review	review	NOUN
admet-194	4	4	,	,	PUNCT
admet-194	4	5	we	we	PRON
admet-194	4	6	firstly	firstly	ADV
admet-194	4	7	introduce	introduce	VERB
admet-194	4	8	the	the	DET
admet-194	4	9	neurobiological	neurobiological	ADJ
admet-194	4	10	concept	concept	NOUN
admet-194	4	11	of	of	ADP
admet-194	4	12	ad	ad	NOUN
admet-194	4	13	,	,	PUNCT
admet-194	4	14	and	and	CCONJ
admet-194	4	15	its	its	PRON
admet-194	4	16	pathogenesis	pathogenesis	NOUN
admet-194	4	17	.	.	PUNCT
admet-194	5	1	then	then	ADV
admet-194	5	2	we	we	PRON
admet-194	5	3	review	review	VERB
admet-194	5	4	the	the	DET
admet-194	5	5	chemical	chemical	NOUN
admet-194	5	6	approaches	approach	VERB
admet-194	5	7	pointedly	pointedly	ADV
admet-194	5	8	directing	direct	VERB
admet-194	5	9	at	at	ADP
admet-194	5	10	aβ	aβ	NOUN
admet-194	5	11	peptide	peptide	NOUN
admet-194	5	12	and	and	CCONJ
admet-194	5	13	tau	tau	PROPN
admet-194	5	14	protein	protein	NOUN
admet-194	5	15	,	,	PUNCT
admet-194	5	16	and	and	CCONJ
admet-194	5	17	the	the	DET
admet-194	5	18	clinical	clinical	ADJ
admet-194	5	19	reality	reality	NOUN
admet-194	5	20	of	of	ADP
admet-194	5	21	these	these	DET
admet-194	5	22	pharmacological	pharmacological	ADJ
admet-194	5	23	strategies	strategy	NOUN
admet-194	5	24	.	.	PUNCT
admet-194	6	1	thirdly	thirdly	ADV
admet-194	6	2	,	,	PUNCT
admet-194	6	3	we	we	PRON
admet-194	6	4	discuss	discuss	VERB
admet-194	6	5	a	a	DET
admet-194	6	6	physical	physical	ADJ
admet-194	6	7	approach	approach	NOUN
admet-194	6	8	,	,	PUNCT
admet-194	6	9	deep	deep	ADJ
admet-194	6	10	brain	brain	NOUN
admet-194	6	11	stimulation	stimulation	NOUN
admet-194	6	12	(	(	PUNCT
admet-194	6	13	dbs	dbs	PROPN
admet-194	6	14	)	)	PUNCT
admet-194	6	15	,	,	PUNCT
admet-194	6	16	which	which	PRON
admet-194	6	17	is	be	AUX
admet-194	6	18	receiving	receive	VERB
admet-194	6	19	considerable	considerable	ADJ
admet-194	6	20	attention	attention	NOUN
admet-194	6	21	in	in	ADP
admet-194	6	22	recent	recent	ADJ
admet-194	6	23	years	year	NOUN
admet-194	6	24	due	due	ADP
admet-194	6	25	to	to	ADP
admet-194	6	26	its	its	PRON
admet-194	6	27	success	success	NOUN
admet-194	6	28	in	in	ADP
admet-194	6	29	treating	treat	VERB
admet-194	6	30	parkinson	parkinson	NOUN
admet-194	6	31	disease	disease	NOUN
admet-194	6	32	clinically	clinically	ADV
admet-194	6	33	.	.	PUNCT
admet-194	7	1	dbs	dbs	PROPN
admet-194	7	2	delivers	deliver	VERB
admet-194	7	3	current	current	ADJ
admet-194	7	4	pulses	pulse	NOUN
admet-194	7	5	,	,	PUNCT
admet-194	7	6	which	which	PRON
admet-194	7	7	are	be	AUX
admet-194	7	8	generated	generate	VERB
admet-194	7	9	by	by	ADP
admet-194	7	10	a	a	DET
admet-194	7	11	implanted	implant	VERB
admet-194	7	12	pacemaker	pacemaker	NOUN
admet-194	7	13	,	,	PUNCT
admet-194	7	14	through	through	ADP
admet-194	7	15	electrodes	electrode	NOUN
admet-194	7	16	into	into	ADP
admet-194	7	17	dysfunctional	dysfunctional	ADJ
admet-194	7	18	brain	brain	NOUN
admet-194	7	19	structures	structure	NOUN
admet-194	7	20	to	to	PART
admet-194	7	21	influence	influence	VERB
admet-194	7	22	neural	neural	ADJ
admet-194	7	23	activities	activity	NOUN
admet-194	7	24	with	with	ADP
admet-194	7	25	the	the	DET
admet-194	7	26	possibility	possibility	NOUN
admet-194	7	27	to	to	PART
admet-194	7	28	improve	improve	VERB
admet-194	7	29	the	the	DET
admet-194	7	30	cognitive	cognitive	ADJ
admet-194	7	31	function	function	NOUN
admet-194	7	32	.	.	PUNCT
admet-194	8	1	we	we	PRON
admet-194	8	2	will	will	AUX
admet-194	8	3	summarize	summarize	VERB
admet-194	8	4	the	the	DET
admet-194	8	5	clinical	clinical	ADJ
admet-194	8	6	applications	application	NOUN
admet-194	8	7	of	of	ADP
admet-194	8	8	dbs	dbs	NOUN
admet-194	8	9	to	to	PART
admet-194	8	10	restore	restore	VERB
admet-194	8	11	cognitive	cognitive	ADJ
admet-194	8	12	impairments	impairment	NOUN
admet-194	8	13	due	due	ADP
admet-194	8	14	to	to	ADP
admet-194	8	15	ad	ad	NOUN
admet-194	8	16	,	,	PUNCT
admet-194	8	17	and	and	CCONJ
admet-194	8	18	animal	animal	NOUN
admet-194	8	19	studies	study	NOUN
admet-194	8	20	related	relate	VERB
admet-194	8	21	with	with	ADP
admet-194	8	22	dbs	dbs	PROPN
admet-194	8	23	.	.	PUNCT
admet-194	9	1	finally	finally	ADV
admet-194	9	2	,	,	PUNCT
admet-194	9	3	we	we	PRON
admet-194	9	4	will	will	AUX
admet-194	9	5	discuss	discuss	VERB
admet-194	9	6	the	the	DET
admet-194	9	7	current	current	ADJ
admet-194	9	8	study	study	NOUN
admet-194	9	9	obstacles	obstacle	NOUN
admet-194	9	10	and	and	CCONJ
admet-194	9	11	future	future	ADJ
admet-194	9	12	research	research	NOUN
admet-194	9	13	development	development	NOUN
admet-194	9	14	of	of	ADP
admet-194	9	15	dbs	dbs	PROPN
admet-194	9	16	in	in	ADP
admet-194	9	17	preclinical	preclinical	ADJ
admet-194	9	18	and	and	CCONJ
admet-194	9	19	clinical	clinical	ADJ
admet-194	9	20	investigations	investigation	NOUN
admet-194	9	21	of	of	ADP
admet-194	9	22	ad	ad	NOUN
admet-194	9	23	.	.	PUNCT
admet-194	10	1	keywords	keyword	VERB
admet-194	10	2	alzheimer	alzheimer	PROPN
admet-194	10	3	’s	’s	PART
admet-194	10	4	disease	disease	NOUN
admet-194	10	5	;	;	PUNCT
admet-194	10	6	neurobiological	neurobiological	ADJ
admet-194	10	7	pathogenesis	pathogenesis	NOUN
admet-194	10	8	;	;	PUNCT
admet-194	10	9	β	β	X
admet-194	10	10	-	-	NOUN
admet-194	10	11	amyloid	amyloid	NOUN
admet-194	10	12	peptide	peptide	NOUN
admet-194	10	13	;	;	PUNCT
admet-194	10	14	tau	tau	PROPN
admet-194	10	15	protein	protein	NOUN
admet-194	10	16	;	;	PUNCT
admet-194	10	17	pharmacological	pharmacological	ADJ
admet-194	10	18	strategies	strategy	NOUN
admet-194	10	19	;	;	PUNCT
admet-194	10	20	deep	deep	ADJ
admet-194	10	21	brain	brain	NOUN
admet-194	10	22	stimulation	stimulation	NOUN
admet-194	10	23	1	1	NUM
admet-194	10	24	.	.	PUNCT
admet-194	11	1	introduction	introduction	NOUN
admet-194	11	2	a	a	DET
admet-194	11	3	growing	grow	VERB
admet-194	11	4	number	number	NOUN
admet-194	11	5	of	of	ADP
admet-194	11	6	people	people	NOUN
admet-194	11	7	suffer	suffer	VERB
admet-194	11	8	from	from	ADP
admet-194	11	9	ad	ad	NOUN
admet-194	11	10	due	due	ADP
admet-194	11	11	to	to	ADP
admet-194	11	12	the	the	DET
admet-194	11	13	aggravation	aggravation	NOUN
admet-194	11	14	of	of	ADP
admet-194	11	15	social	social	ADJ
admet-194	11	16	aging	aging	NOUN
admet-194	11	17	and	and	CCONJ
admet-194	11	18	the	the	DET
admet-194	11	19	dilation	dilation	NOUN
admet-194	11	20	of	of	ADP
admet-194	11	21	average	average	ADJ
admet-194	11	22	life	life	NOUN
admet-194	11	23	expectancy	expectancy	NOUN
admet-194	11	24	,	,	PUNCT
admet-194	11	25	which	which	PRON
admet-194	11	26	brings	bring	VERB
admet-194	11	27	about	about	ADP
admet-194	11	28	heavy	heavy	ADJ
admet-194	11	29	burden	burden	NOUN
admet-194	11	30	to	to	ADP
admet-194	11	31	the	the	DET
admet-194	11	32	families	family	NOUN
admet-194	11	33	,	,	PUNCT
admet-194	11	34	the	the	DET
admet-194	11	35	society	society	NOUN
admet-194	11	36	and	and	CCONJ
admet-194	11	37	the	the	DET
admet-194	11	38	whole	whole	ADJ
admet-194	11	39	world	world	NOUN
admet-194	12	1	[	[	X
admet-194	12	2	1	1	NUM
admet-194	12	3	]	]	PUNCT
admet-194	12	4	.	.	PUNCT
admet-194	13	1	therefore	therefore	ADV
admet-194	13	2	numerous	numerous	ADJ
admet-194	13	3	researchers	researcher	NOUN
admet-194	13	4	and	and	CCONJ
admet-194	13	5	clinicians	clinician	NOUN
admet-194	13	6	have	have	AUX
admet-194	13	7	spent	spend	VERB
admet-194	13	8	considerable	considerable	ADJ
admet-194	13	9	effort	effort	NOUN
admet-194	13	10	to	to	PART
admet-194	13	11	find	find	VERB
admet-194	13	12	a	a	DET
admet-194	13	13	cure	cure	NOUN
admet-194	13	14	.	.	PUNCT
admet-194	14	1	the	the	DET
admet-194	14	2	initial	initial	ADJ
admet-194	14	3	histopathologic	histopathologic	ADJ
admet-194	14	4	hallmarks	hallmark	NOUN
admet-194	14	5	of	of	ADP
admet-194	14	6	ad	ad	NOUN
admet-194	14	7	are	be	AUX
admet-194	14	8	the	the	DET
admet-194	14	9	presence	presence	NOUN
admet-194	14	10	of	of	ADP
admet-194	14	11	intracellular	intracellular	ADJ
admet-194	14	12	neurofibrillary	neurofibrillary	ADJ
admet-194	14	13	tangles	tangle	NOUN
admet-194	14	14	(	(	PUNCT
admet-194	14	15	nfts	nft	NOUN
admet-194	14	16	)	)	PUNCT
admet-194	14	17	and	and	CCONJ
admet-194	14	18	extracellular	extracellular	ADJ
admet-194	14	19	depositional	depositional	ADJ
admet-194	14	20	β	β	NOUN
admet-194	14	21	-	-	NOUN
admet-194	14	22	amyloid	amyloid	NOUN
admet-194	14	23	(	(	PUNCT
admet-194	14	24	aβ	aβ	NOUN
admet-194	14	25	)	)	PUNCT
admet-194	14	26	plaques	plaque	NOUN
admet-194	14	27	[	[	X
admet-194	14	28	2	2	NUM
admet-194	14	29	]	]	PUNCT
admet-194	14	30	.	.	PUNCT
admet-194	15	1	other	other	ADJ
admet-194	15	2	histopathologic	histopathologic	ADJ
admet-194	15	3	distinctions	distinction	NOUN
admet-194	15	4	differing	differ	VERB
admet-194	15	5	from	from	ADP
admet-194	15	6	healthy	healthy	ADJ
admet-194	15	7	people	people	NOUN
admet-194	15	8	are	be	AUX
admet-194	15	9	loss	loss	NOUN
admet-194	15	10	of	of	ADP
admet-194	15	11	hippocampal	hippocampal	ADJ
admet-194	15	12	neurons	neuron	NOUN
admet-194	15	13	and	and	CCONJ
admet-194	15	14	degeneration	degeneration	NOUN
admet-194	15	15	of	of	ADP
admet-194	15	16	synapses	synapsis	NOUN
admet-194	15	17	[	[	X
admet-194	15	18	3	3	NUM
admet-194	15	19	]	]	PUNCT
admet-194	15	20	.	.	PUNCT
admet-194	16	1	ad	ad	NOUN
admet-194	16	2	is	be	AUX
admet-194	16	3	difficult	difficult	ADJ
admet-194	16	4	to	to	PART
admet-194	16	5	diagnosis	diagnosis	VERB
admet-194	16	6	for	for	ADP
admet-194	16	7	its	its	PRON
admet-194	16	8	inconspicuous	inconspicuous	ADJ
admet-194	16	9	initial	initial	ADJ
admet-194	16	10	symptoms	symptom	NOUN
admet-194	16	11	.	.	PUNCT
admet-194	17	1	the	the	DET
admet-194	17	2	disruption	disruption	NOUN
admet-194	17	3	of	of	ADP
admet-194	17	4	episodic	episodic	ADJ
admet-194	17	5	memory	memory	NOUN
admet-194	17	6	,	,	PUNCT
admet-194	17	7	emerging	emerge	VERB
admet-194	17	8	firstly	firstly	ADV
admet-194	17	9	in	in	ADP
admet-194	17	10	ad	ad	NOUN
admet-194	17	11	patients	patient	NOUN
admet-194	17	12	[	[	X
admet-194	17	13	4,5	4,5	NUM
admet-194	17	14	]	]	PUNCT
admet-194	17	15	,	,	PUNCT
admet-194	17	16	as	as	ADV
admet-194	17	17	well	well	ADV
admet-194	17	18	as	as	ADP
admet-194	17	19	other	other	ADJ
admet-194	17	20	subsequent	subsequent	ADJ
admet-194	17	21	cognitive	cognitive	ADJ
admet-194	17	22	impairments	impairment	NOUN
admet-194	17	23	,	,	PUNCT
admet-194	17	24	especially	especially	ADV
admet-194	17	25	in	in	ADP
admet-194	17	26	attention	attention	NOUN
admet-194	17	27	and	and	CCONJ
admet-194	17	28	execution	execution	NOUN
admet-194	17	29	,	,	PUNCT
admet-194	17	30	semantic	semantic	ADJ
admet-194	17	31	memory	memory	NOUN
admet-194	17	32	,	,	PUNCT
admet-194	17	33	language	language	NOUN
admet-194	17	34	expression	expression	NOUN
admet-194	17	35	,	,	PUNCT
admet-194	17	36	and	and	CCONJ
admet-194	17	37	orientation	orientation	NOUN
admet-194	18	1	[	[	X
admet-194	18	2	6,7	6,7	NUM
admet-194	18	3	]	]	PUNCT
admet-194	18	4	may	may	AUX
admet-194	18	5	not	not	PART
admet-194	18	6	draw	draw	VERB
admet-194	18	7	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-194	18	8	admet	admet	PROPN
admet-194	18	9	&	&	CCONJ
admet-194	18	10	dmpk	dmpk	PROPN
admet-194	18	11	3(3	3(3	NUM
admet-194	18	12	)	)	PUNCT
admet-194	18	13	(	(	PUNCT
admet-194	18	14	2015	2015	NUM
admet-194	18	15	)	)	PUNCT
admet-194	18	16	216	216	NUM
admet-194	18	17	-	-	SYM
admet-194	18	18	234	234	NUM
admet-194	18	19	chemical	chemical	NOUN
admet-194	18	20	and	and	CCONJ
admet-194	18	21	physical	physical	ADJ
admet-194	18	22	approaches	approach	NOUN
admet-194	18	23	for	for	ADP
admet-194	18	24	the	the	DET
admet-194	18	25	treatment	treatment	NOUN
admet-194	18	26	of	of	ADP
admet-194	18	27	ad	ad	NOUN
admet-194	18	28	doi	doi	NOUN
admet-194	18	29	:	:	PUNCT
admet-194	18	30	10.5599	10.5599	NUM
admet-194	18	31	/	/	SYM
admet-194	18	32	admet.3.3.194	admet.3.3.194	PROPN
admet-194	18	33	217	217	NUM
admet-194	18	34	attention	attention	NOUN
admet-194	18	35	of	of	ADP
admet-194	18	36	patients	patient	NOUN
admet-194	18	37	and	and	CCONJ
admet-194	18	38	their	their	PRON
admet-194	18	39	family	family	NOUN
admet-194	18	40	members	member	NOUN
admet-194	18	41	.	.	PUNCT
admet-194	19	1	the	the	DET
admet-194	19	2	clinical	clinical	ADJ
admet-194	19	3	diagnosis	diagnosis	NOUN
admet-194	19	4	of	of	ADP
admet-194	19	5	ad	ad	NOUN
admet-194	19	6	would	would	AUX
admet-194	19	7	not	not	PART
admet-194	19	8	be	be	AUX
admet-194	19	9	definitive	definitive	ADJ
admet-194	19	10	until	until	SCONJ
admet-194	19	11	the	the	DET
admet-194	19	12	cognitive	cognitive	ADJ
admet-194	19	13	impairments	impairment	NOUN
admet-194	19	14	become	become	VERB
admet-194	19	15	serious	serious	ADJ
admet-194	19	16	enough	enough	ADV
admet-194	19	17	to	to	PART
admet-194	19	18	affect	affect	VERB
admet-194	19	19	normal	normal	ADJ
admet-194	19	20	social	social	ADJ
admet-194	19	21	function	function	NOUN
admet-194	19	22	.	.	PUNCT
admet-194	20	1	pathogenesis	pathogenesis	NOUN
admet-194	20	2	of	of	ADP
admet-194	20	3	ad	ad	NOUN
admet-194	20	4	is	be	AUX
admet-194	20	5	considered	consider	VERB
admet-194	20	6	to	to	PART
admet-194	20	7	be	be	AUX
admet-194	20	8	the	the	DET
admet-194	20	9	result	result	NOUN
admet-194	20	10	of	of	ADP
admet-194	20	11	the	the	DET
admet-194	20	12	accumulation	accumulation	NOUN
admet-194	20	13	of	of	ADP
admet-194	20	14	the	the	DET
admet-194	20	15	aβ	aβ	NOUN
admet-194	20	16	,	,	PUNCT
admet-194	20	17	which	which	PRON
admet-194	20	18	is	be	AUX
admet-194	20	19	triggered	trigger	VERB
admet-194	20	20	by	by	ADP
admet-194	20	21	the	the	DET
admet-194	20	22	overproduction	overproduction	NOUN
admet-194	20	23	of	of	ADP
admet-194	20	24	aβ	aβ	PRON
admet-194	20	25	and	and	CCONJ
admet-194	20	26	the	the	DET
admet-194	20	27	lack	lack	NOUN
admet-194	20	28	of	of	ADP
admet-194	20	29	clearance	clearance	NOUN
admet-194	20	30	mechanisms	mechanism	NOUN
admet-194	20	31	.	.	PUNCT
admet-194	21	1	aβ	aβ	PRON
admet-194	21	2	self	self	NOUN
admet-194	21	3	-	-	PUNCT
admet-194	21	4	aggregates	aggregate	NOUN
admet-194	21	5	into	into	ADP
admet-194	21	6	oligomers	oligomer	NOUN
admet-194	21	7	,	,	PUNCT
admet-194	21	8	and	and	CCONJ
admet-194	21	9	then	then	ADV
admet-194	21	10	forms	form	VERB
admet-194	21	11	neuritic	neuritic	ADJ
admet-194	21	12	plaques	plaque	NOUN
admet-194	21	13	in	in	ADP
admet-194	21	14	brain	brain	NOUN
admet-194	22	1	[	[	X
admet-194	22	2	8	8	NUM
admet-194	22	3	]	]	PUNCT
admet-194	22	4	.	.	PUNCT
admet-194	23	1	the	the	DET
admet-194	23	2	potent	potent	ADJ
admet-194	23	3	synaptotoxin	synaptotoxin	NOUN
admet-194	23	4	of	of	ADP
admet-194	23	5	insoluble	insoluble	ADJ
admet-194	23	6	aβ	aβ	NOUN
admet-194	23	7	plaques	plaque	NOUN
admet-194	23	8	is	be	AUX
admet-194	23	9	endangering	endanger	VERB
admet-194	23	10	proteasome	proteasome	NOUN
admet-194	23	11	function	function	NOUN
admet-194	23	12	,	,	PUNCT
admet-194	23	13	mitochondrial	mitochondrial	ADJ
admet-194	23	14	activity	activity	NOUN
admet-194	23	15	,	,	PUNCT
admet-194	23	16	neuronal	neuronal	ADJ
admet-194	23	17	function	function	NOUN
admet-194	23	18	and	and	CCONJ
admet-194	23	19	so	so	ADV
admet-194	23	20	forth	forth	ADV
admet-194	23	21	.	.	PUNCT
admet-194	24	1	on	on	ADP
admet-194	24	2	the	the	DET
admet-194	24	3	other	other	ADJ
admet-194	24	4	hand	hand	NOUN
admet-194	24	5	,	,	PUNCT
admet-194	24	6	hyperphosphorylated	hyperphosphorylate	VERB
admet-194	24	7	tau	tau	PROPN
admet-194	24	8	destabilizes	destabilize	VERB
admet-194	24	9	microtubules	microtubule	NOUN
admet-194	24	10	,	,	PUNCT
admet-194	24	11	resulting	result	VERB
admet-194	24	12	in	in	ADP
admet-194	24	13	the	the	DET
admet-194	24	14	damage	damage	NOUN
admet-194	24	15	of	of	ADP
admet-194	24	16	axonal	axonal	ADJ
admet-194	24	17	transport	transport	NOUN
admet-194	24	18	and	and	CCONJ
admet-194	24	19	then	then	ADV
admet-194	24	20	leading	lead	VERB
admet-194	24	21	to	to	ADP
admet-194	24	22	neuronal	neuronal	ADJ
admet-194	24	23	dysfunction	dysfunction	NOUN
admet-194	24	24	[	[	X
admet-194	24	25	9	9	NUM
admet-194	24	26	]	]	PUNCT
admet-194	24	27	.	.	PUNCT
admet-194	25	1	moreover	moreover	ADV
admet-194	25	2	,	,	PUNCT
admet-194	25	3	hyperphosphorylated	hyperphosphorylated	ADJ
admet-194	25	4	tau	tau	PROPN
admet-194	25	5	can	can	AUX
admet-194	25	6	self	self	NOUN
admet-194	25	7	-	-	PUNCT
admet-194	25	8	accumulate	accumulate	NOUN
admet-194	25	9	into	into	ADP
admet-194	25	10	nfts	nft	NOUN
admet-194	25	11	which	which	PRON
admet-194	25	12	are	be	AUX
admet-194	25	13	also	also	ADV
admet-194	25	14	harmful	harmful	ADJ
admet-194	25	15	to	to	ADP
admet-194	25	16	neurons	neuron	NOUN
admet-194	25	17	.	.	PUNCT
admet-194	26	1	furthermore	furthermore	ADV
admet-194	26	2	,	,	PUNCT
admet-194	26	3	the	the	DET
admet-194	26	4	cleanup	cleanup	NOUN
admet-194	26	5	process	process	NOUN
admet-194	26	6	of	of	ADP
admet-194	26	7	hyperphosphorylated	hyperphosphorylated	ADJ
admet-194	26	8	tau	tau	PROPN
admet-194	26	9	is	be	AUX
admet-194	26	10	suppressed	suppress	VERB
admet-194	26	11	by	by	ADP
admet-194	26	12	the	the	DET
admet-194	26	13	actions	action	NOUN
admet-194	26	14	of	of	ADP
admet-194	26	15	aβ	aβ	NOUN
admet-194	26	16	[	[	X
admet-194	26	17	10	10	NUM
admet-194	26	18	]	]	PUNCT
admet-194	26	19	.	.	PUNCT
admet-194	27	1	therefore	therefore	ADV
admet-194	27	2	,	,	PUNCT
admet-194	27	3	aβ	aβ	PRON
admet-194	27	4	cascade	cascade	NOUN
admet-194	27	5	and	and	CCONJ
admet-194	27	6	hyperphosphorylated	hyperphosphorylate	VERB
admet-194	27	7	tau	tau	PROPN
admet-194	27	8	protein	protein	NOUN
admet-194	27	9	represent	represent	VERB
admet-194	27	10	two	two	NUM
admet-194	27	11	essential	essential	ADJ
admet-194	27	12	therapeutic	therapeutic	ADJ
admet-194	27	13	targets	target	NOUN
admet-194	27	14	for	for	ADP
admet-194	27	15	researchers	researcher	NOUN
admet-194	27	16	and	and	CCONJ
admet-194	27	17	clinicians	clinician	NOUN
admet-194	27	18	.	.	PUNCT
admet-194	28	1	the	the	DET
admet-194	28	2	effective	effective	ADJ
admet-194	28	3	pharmacological	pharmacological	ADJ
admet-194	28	4	treatment	treatment	NOUN
admet-194	28	5	and	and	CCONJ
admet-194	28	6	prevention	prevention	NOUN
admet-194	28	7	of	of	ADP
admet-194	28	8	ad	ad	NOUN
admet-194	28	9	is	be	AUX
admet-194	28	10	exactly	exactly	ADV
admet-194	28	11	the	the	DET
admet-194	28	12	disease	disease	NOUN
admet-194	28	13	-	-	PUNCT
admet-194	28	14	modifying	modify	VERB
admet-194	28	15	therapies	therapy	NOUN
admet-194	28	16	which	which	PRON
admet-194	28	17	researchers	researcher	NOUN
admet-194	28	18	and	and	CCONJ
admet-194	28	19	clinicians	clinician	NOUN
admet-194	28	20	are	be	AUX
admet-194	28	21	now	now	ADV
admet-194	28	22	trying	try	VERB
admet-194	28	23	to	to	PART
admet-194	28	24	develop	develop	VERB
admet-194	28	25	.	.	PUNCT
admet-194	29	1	as	as	ADP
admet-194	29	2	aβ	aβ	PRON
admet-194	29	3	cascade	cascade	NOUN
admet-194	29	4	and	and	CCONJ
admet-194	29	5	hyperphosphorylated	hyperphosphorylate	VERB
admet-194	29	6	tau	tau	PROPN
admet-194	29	7	protein	protein	NOUN
admet-194	29	8	are	be	AUX
admet-194	29	9	generally	generally	ADV
admet-194	29	10	recognized	recognize	VERB
admet-194	29	11	as	as	ADP
admet-194	29	12	vital	vital	ADJ
admet-194	29	13	therapeutic	therapeutic	ADJ
admet-194	29	14	targets	target	NOUN
admet-194	29	15	,	,	PUNCT
admet-194	29	16	the	the	DET
admet-194	29	17	processes	process	NOUN
admet-194	29	18	of	of	ADP
admet-194	29	19	developing	develop	VERB
admet-194	29	20	disease	disease	NOUN
admet-194	29	21	-	-	PUNCT
admet-194	29	22	modifying	modify	VERB
admet-194	29	23	therapies	therapy	NOUN
admet-194	29	24	are	be	AUX
admet-194	29	25	concentrated	concentrate	VERB
admet-194	29	26	on	on	ADP
admet-194	29	27	them	they	PRON
admet-194	30	1	[	[	X
admet-194	30	2	11,12	11,12	NUM
admet-194	30	3	]	]	PUNCT
admet-194	30	4	.	.	PUNCT
admet-194	31	1	here	here	ADV
admet-194	31	2	we	we	PRON
admet-194	31	3	address	address	VERB
admet-194	31	4	the	the	DET
admet-194	31	5	4	4	NUM
admet-194	31	6	main	main	ADJ
admet-194	31	7	strategies	strategy	NOUN
admet-194	31	8	focusing	focus	VERB
admet-194	31	9	on	on	ADP
admet-194	31	10	aβ	aβ	DET
admet-194	31	11	cascade	cascade	NOUN
admet-194	31	12	from	from	ADP
admet-194	31	13	different	different	ADJ
admet-194	31	14	directions	direction	NOUN
admet-194	31	15	,	,	PUNCT
admet-194	31	16	and	and	CCONJ
admet-194	31	17	5	5	NUM
admet-194	31	18	diverse	diverse	ADJ
admet-194	31	19	means	mean	VERB
admet-194	31	20	aiming	aim	VERB
admet-194	31	21	at	at	ADP
admet-194	31	22	hyperphosphorylated	hyperphosphorylate	VERB
admet-194	31	23	tau	tau	PROPN
admet-194	31	24	in	in	ADP
admet-194	31	25	details	detail	NOUN
admet-194	31	26	.	.	PUNCT
admet-194	32	1	it	it	PRON
admet-194	32	2	is	be	AUX
admet-194	32	3	important	important	ADJ
admet-194	32	4	to	to	PART
admet-194	32	5	note	note	VERB
admet-194	32	6	that	that	SCONJ
admet-194	32	7	we	we	PRON
admet-194	32	8	have	have	AUX
admet-194	32	9	already	already	ADV
admet-194	32	10	faced	face	VERB
admet-194	32	11	many	many	ADJ
admet-194	32	12	failures	failure	NOUN
admet-194	32	13	in	in	ADP
admet-194	32	14	the	the	DET
admet-194	32	15	course	course	NOUN
admet-194	32	16	of	of	ADP
admet-194	32	17	developing	develop	VERB
admet-194	32	18	diseasemodifying	diseasemodifye	VERB
admet-194	32	19	therapies	therapy	NOUN
admet-194	32	20	,	,	PUNCT
admet-194	32	21	while	while	SCONJ
admet-194	32	22	it	it	PRON
admet-194	32	23	is	be	AUX
admet-194	32	24	nice	nice	ADJ
admet-194	32	25	to	to	PART
admet-194	32	26	see	see	VERB
admet-194	32	27	some	some	DET
admet-194	32	28	successes	success	NOUN
admet-194	32	29	in	in	ADP
admet-194	32	30	the	the	DET
admet-194	32	31	development	development	NOUN
admet-194	32	32	of	of	ADP
admet-194	32	33	symptomatic	symptomatic	ADJ
admet-194	32	34	treatment	treatment	NOUN
admet-194	32	35	therapies	therapy	NOUN
admet-194	32	36	[	[	X
admet-194	32	37	13	13	NUM
admet-194	32	38	]	]	PUNCT
admet-194	32	39	.	.	PUNCT
admet-194	33	1	available	available	ADJ
admet-194	33	2	drugs	drug	NOUN
admet-194	33	3	nowadays	nowadays	ADV
admet-194	33	4	for	for	ADP
admet-194	33	5	treating	treat	VERB
admet-194	33	6	alzheimer	alzheimer	PROPN
admet-194	33	7	’s	’s	PART
admet-194	33	8	disease	disease	NOUN
admet-194	33	9	are	be	AUX
admet-194	33	10	directing	direct	VERB
admet-194	33	11	on	on	ADP
admet-194	33	12	cholinesterase	cholinesterase	NOUN
admet-194	33	13	and	and	CCONJ
admet-194	33	14	n	n	CCONJ
admet-194	33	15	-	-	PUNCT
admet-194	33	16	methyl	methyl	NOUN
admet-194	33	17	-	-	PUNCT
admet-194	33	18	d	d	NOUN
admet-194	33	19	-	-	NOUN
admet-194	33	20	aspartate	aspartate	ADJ
admet-194	33	21	(	(	PUNCT
admet-194	33	22	amda	amda	ADJ
admet-194	33	23	)	)	PUNCT
admet-194	33	24	receptor	receptor	NOUN
admet-194	33	25	,	,	PUNCT
admet-194	33	26	which	which	PRON
admet-194	33	27	are	be	AUX
admet-194	33	28	donepezil	donepezil	NOUN
admet-194	33	29	,	,	PUNCT
admet-194	33	30	galantamine	galantamine	NOUN
admet-194	33	31	,	,	PUNCT
admet-194	33	32	rivastigmine	rivastigmine	NOUN
admet-194	33	33	and	and	CCONJ
admet-194	33	34	huperzine	huperzine	NOUN
admet-194	33	35	a	a	PRON
admet-194	33	36	,	,	PUNCT
admet-194	33	37	as	as	ADV
admet-194	33	38	well	well	ADV
admet-194	33	39	as	as	ADP
admet-194	33	40	memantine	memantine	ADJ
admet-194	33	41	[	[	X
admet-194	33	42	1,12,13	1,12,13	NUM
admet-194	33	43	]	]	PUNCT
admet-194	33	44	.	.	PUNCT
admet-194	34	1	in	in	ADP
admet-194	34	2	addition	addition	NOUN
admet-194	34	3	to	to	ADP
admet-194	34	4	the	the	DET
admet-194	34	5	traditional	traditional	ADJ
admet-194	34	6	ad	ad	NOUN
admet-194	34	7	-	-	PUNCT
admet-194	34	8	oriented	orient	VERB
admet-194	34	9	chemical	chemical	NOUN
admet-194	34	10	methods	method	NOUN
admet-194	34	11	,	,	PUNCT
admet-194	34	12	one	one	NUM
admet-194	34	13	physical	physical	ADJ
admet-194	34	14	method	method	NOUN
admet-194	34	15	,	,	PUNCT
admet-194	34	16	which	which	PRON
admet-194	34	17	is	be	AUX
admet-194	34	18	called	call	VERB
admet-194	34	19	deep	deep	ADJ
admet-194	34	20	brain	brain	NOUN
admet-194	34	21	stimulation	stimulation	NOUN
admet-194	34	22	(	(	PUNCT
admet-194	34	23	dbs	dbs	PROPN
admet-194	34	24	)	)	PUNCT
admet-194	34	25	,	,	PUNCT
admet-194	34	26	appears	appear	VERB
admet-194	34	27	to	to	PART
admet-194	34	28	be	be	AUX
admet-194	34	29	a	a	DET
admet-194	34	30	promising	promising	ADJ
admet-194	34	31	approach	approach	NOUN
admet-194	34	32	to	to	PART
admet-194	34	33	modulate	modulate	VERB
admet-194	34	34	the	the	DET
admet-194	34	35	symptoms	symptom	NOUN
admet-194	34	36	of	of	ADP
admet-194	34	37	some	some	DET
admet-194	34	38	neurodegenerative	neurodegenerative	ADJ
admet-194	34	39	diseases	disease	NOUN
admet-194	34	40	[	[	X
admet-194	34	41	14	14	NUM
admet-194	34	42	]	]	PUNCT
admet-194	34	43	.	.	PUNCT
admet-194	35	1	existing	exist	VERB
admet-194	35	2	for	for	ADP
admet-194	35	3	years	year	NOUN
admet-194	35	4	,	,	PUNCT
admet-194	35	5	dbs	dbs	PROPN
admet-194	35	6	is	be	AUX
admet-194	35	7	a	a	DET
admet-194	35	8	fairly	fairly	ADV
admet-194	35	9	minimally	minimally	ADV
admet-194	35	10	invasive	invasive	ADJ
admet-194	35	11	neurological	neurological	ADJ
admet-194	35	12	procedure	procedure	NOUN
admet-194	35	13	which	which	PRON
admet-194	35	14	involves	involve	VERB
admet-194	35	15	the	the	DET
admet-194	35	16	implantation	implantation	NOUN
admet-194	35	17	of	of	ADP
admet-194	35	18	a	a	DET
admet-194	35	19	brain	brain	NOUN
admet-194	35	20	pacemaker	pacemaker	NOUN
admet-194	35	21	sending	send	VERB
admet-194	35	22	mild	mild	ADJ
admet-194	35	23	electrical	electrical	ADJ
admet-194	35	24	impulses	impulse	NOUN
admet-194	35	25	to	to	PART
admet-194	35	26	target	target	VERB
admet-194	35	27	encephalic	encephalic	ADJ
admet-194	35	28	regions	region	NOUN
admet-194	35	29	,	,	PUNCT
admet-194	35	30	with	with	ADP
admet-194	35	31	the	the	DET
admet-194	35	32	aim	aim	NOUN
admet-194	35	33	to	to	PART
admet-194	35	34	treat	treat	VERB
admet-194	35	35	certain	certain	ADJ
admet-194	35	36	affective	affective	NOUN
admet-194	35	37	and	and	CCONJ
admet-194	35	38	movement	movement	NOUN
admet-194	35	39	disorders	disorder	NOUN
admet-194	35	40	[	[	X
admet-194	35	41	15	15	NUM
admet-194	35	42	]	]	PUNCT
admet-194	35	43	.	.	PUNCT
admet-194	36	1	the	the	DET
admet-194	36	2	origins	origin	NOUN
admet-194	36	3	of	of	ADP
admet-194	36	4	dbs	dbs	PROPN
admet-194	36	5	are	be	AUX
admet-194	36	6	connected	connect	VERB
admet-194	36	7	to	to	ADP
admet-194	36	8	the	the	DET
admet-194	36	9	beneficial	beneficial	ADJ
admet-194	36	10	effects	effect	NOUN
admet-194	36	11	of	of	ADP
admet-194	36	12	electrical	electrical	ADJ
admet-194	36	13	stimulation	stimulation	NOUN
admet-194	36	14	in	in	ADP
admet-194	36	15	certain	certain	ADJ
admet-194	36	16	deep	deep	ADJ
admet-194	36	17	brain	brain	NOUN
admet-194	36	18	areas	area	NOUN
admet-194	36	19	,	,	PUNCT
admet-194	36	20	and	and	CCONJ
admet-194	36	21	performed	perform	VERB
admet-194	36	22	during	during	ADP
admet-194	36	23	the	the	DET
admet-194	36	24	stereotactic	stereotactic	ADJ
admet-194	36	25	functional	functional	ADJ
admet-194	36	26	neurosurgery	neurosurgery	NOUN
admet-194	36	27	to	to	PART
admet-194	36	28	identify	identify	VERB
admet-194	36	29	the	the	DET
admet-194	36	30	right	right	ADJ
admet-194	36	31	position	position	NOUN
admet-194	36	32	of	of	ADP
admet-194	36	33	the	the	DET
admet-194	36	34	electrodes	electrode	NOUN
admet-194	36	35	for	for	ADP
admet-194	36	36	treating	treat	VERB
admet-194	36	37	movement	movement	NOUN
admet-194	36	38	disorders	disorder	NOUN
admet-194	36	39	and	and	CCONJ
admet-194	36	40	tremor	tremor	NOUN
admet-194	36	41	in	in	ADP
admet-194	36	42	parkinson	parkinson	NOUN
admet-194	36	43	disease	disease	NOUN
admet-194	36	44	(	(	PUNCT
admet-194	36	45	pd	pd	X
admet-194	36	46	)	)	PUNCT
admet-194	37	1	[	[	X
admet-194	37	2	16	16	NUM
admet-194	37	3	]	]	PUNCT
admet-194	37	4	.	.	PUNCT
admet-194	38	1	as	as	SCONJ
admet-194	38	2	the	the	DET
admet-194	38	3	significantly	significantly	ADV
admet-194	38	4	advantageous	advantageous	ADJ
admet-194	38	5	outcomes	outcome	NOUN
admet-194	38	6	and	and	CCONJ
admet-194	38	7	favourable	favourable	ADJ
admet-194	38	8	actions	action	NOUN
admet-194	38	9	result	result	VERB
admet-194	38	10	from	from	ADP
admet-194	38	11	treatment	treatment	NOUN
admet-194	38	12	of	of	ADP
admet-194	38	13	pd	pd	PROPN
admet-194	38	14	which	which	PRON
admet-194	38	15	is	be	AUX
admet-194	38	16	conducted	conduct	VERB
admet-194	38	17	by	by	ADP
admet-194	38	18	dbs	dbs	PROPN
admet-194	38	19	,	,	PUNCT
admet-194	38	20	it	it	PRON
admet-194	38	21	could	could	AUX
admet-194	38	22	be	be	AUX
admet-194	38	23	beneficial	beneficial	ADJ
admet-194	38	24	to	to	PART
admet-194	38	25	apply	apply	VERB
admet-194	38	26	dbs	dbs	NOUN
admet-194	38	27	in	in	ADP
admet-194	38	28	the	the	DET
admet-194	38	29	context	context	NOUN
admet-194	38	30	of	of	ADP
admet-194	38	31	ad	ad	NOUN
admet-194	38	32	,	,	PUNCT
admet-194	38	33	especially	especially	ADV
admet-194	38	34	to	to	PART
admet-194	38	35	mitigate	mitigate	VERB
admet-194	38	36	the	the	DET
admet-194	38	37	symptoms	symptom	NOUN
admet-194	38	38	resulting	result	VERB
admet-194	38	39	from	from	ADP
admet-194	38	40	cognitive	cognitive	ADJ
admet-194	38	41	impairment	impairment	NOUN
admet-194	38	42	.	.	PUNCT
admet-194	39	1	the	the	DET
admet-194	39	2	objective	objective	NOUN
admet-194	39	3	of	of	ADP
admet-194	39	4	this	this	DET
admet-194	39	5	review	review	NOUN
admet-194	39	6	seeks	seek	VERB
admet-194	39	7	to	to	PART
admet-194	39	8	unfold	unfold	VERB
admet-194	39	9	a	a	DET
admet-194	39	10	retrospection	retrospection	NOUN
admet-194	39	11	of	of	ADP
admet-194	39	12	the	the	DET
admet-194	39	13	chemical	chemical	ADJ
admet-194	39	14	anti	anti	ADJ
admet-194	39	15	-	-	ADJ
admet-194	39	16	ad	ad	ADJ
admet-194	39	17	researches	research	NOUN
admet-194	39	18	and	and	CCONJ
admet-194	39	19	clinical	clinical	ADJ
admet-194	39	20	reality	reality	NOUN
admet-194	39	21	of	of	ADP
admet-194	39	22	chemical	chemical	ADJ
admet-194	39	23	treatment	treatment	NOUN
admet-194	39	24	,	,	PUNCT
admet-194	39	25	as	as	ADV
admet-194	39	26	well	well	ADV
admet-194	39	27	as	as	ADP
admet-194	39	28	the	the	DET
admet-194	39	29	physical	physical	ADJ
admet-194	39	30	anti	anti	ADJ
admet-194	39	31	-	-	ADJ
admet-194	39	32	ad	ad	ADJ
admet-194	39	33	strategy	strategy	NOUN
admet-194	39	34	in	in	ADP
admet-194	39	35	both	both	CCONJ
admet-194	39	36	preclinical	preclinical	ADJ
admet-194	39	37	and	and	CCONJ
admet-194	39	38	clinical	clinical	ADJ
admet-194	39	39	studies	study	NOUN
admet-194	39	40	.	.	PUNCT
admet-194	40	1	2	2	X
admet-194	40	2	.	.	X
admet-194	40	3	chemical	chemical	ADJ
admet-194	40	4	methods	method	NOUN
admet-194	40	5	to	to	PART
admet-194	40	6	treat	treat	VERB
admet-194	40	7	ad	ad	NOUN
admet-194	40	8	2.1	2.1	NUM
admet-194	40	9	pharmacological	pharmacological	ADJ
admet-194	40	10	strategies	strategy	NOUN
admet-194	40	11	of	of	ADP
admet-194	40	12	disease	disease	NOUN
admet-194	40	13	-	-	PUNCT
admet-194	40	14	modifying	modify	VERB
admet-194	40	15	therapeutic	therapeutic	ADJ
admet-194	40	16	methods	method	NOUN
admet-194	40	17	2.1.1	2.1.1	NUM
admet-194	40	18	aβ	aβ	NOUN
admet-194	40	19	-	-	PUNCT
admet-194	40	20	targeting	target	VERB
admet-194	40	21	strategies	strategy	NOUN
admet-194	40	22	aβ	aβ	PRON
admet-194	40	23	is	be	AUX
admet-194	40	24	produced	produce	VERB
admet-194	40	25	by	by	ADP
admet-194	40	26	sequential	sequential	ADJ
admet-194	40	27	proteolysis	proteolysis	NOUN
admet-194	40	28	,	,	PUNCT
admet-194	40	29	where	where	SCONJ
admet-194	40	30	the	the	DET
admet-194	40	31	overexpressed	overexpresse	VERB
admet-194	40	32	amyloid	amyloid	NOUN
admet-194	40	33	precursor	precursor	NOUN
admet-194	40	34	protein	protein	NOUN
admet-194	40	35	(	(	PUNCT
admet-194	40	36	app	app	X
admet-194	40	37	)	)	PUNCT
admet-194	40	38	is	be	AUX
admet-194	40	39	successively	successively	ADV
admet-194	40	40	cleaved	cleave	VERB
admet-194	40	41	by	by	ADP
admet-194	40	42	β	β	NOUN
admet-194	40	43	-	-	NOUN
admet-194	40	44	secretase	secretase	NOUN
admet-194	40	45	in	in	ADP
admet-194	40	46	extracellular	extracellular	ADJ
admet-194	40	47	region	region	NOUN
admet-194	40	48	,	,	PUNCT
admet-194	40	49	and	and	CCONJ
admet-194	40	50	γ	γ	NOUN
admet-194	40	51	-	-	NOUN
admet-194	40	52	secretase	secretase	NOUN
admet-194	40	53	in	in	ADP
admet-194	40	54	transmembrane	transmembrane	ADJ
admet-194	40	55	domain	domain	NOUN
admet-194	40	56	[	[	X
admet-194	40	57	17	17	NUM
admet-194	40	58	]	]	PUNCT
admet-194	40	59	.	.	PUNCT
admet-194	41	1	jing	jing	PROPN
admet-194	41	2	li	li	PROPN
admet-194	41	3	et	et	PROPN
admet-194	41	4	al	al	PROPN
admet-194	41	5	.	.	PROPN
admet-194	41	6	admet	admet	PROPN
admet-194	41	7	&	&	CCONJ
admet-194	41	8	dmpk	dmpk	PROPN
admet-194	41	9	3(3	3(3	NUM
admet-194	41	10	)	)	PUNCT
admet-194	41	11	(	(	PUNCT
admet-194	41	12	2015	2015	NUM
admet-194	41	13	)	)	PUNCT
admet-194	41	14	216	216	NUM
admet-194	41	15	-	-	SYM
admet-194	41	16	234	234	NUM
admet-194	41	17	218	218	NUM
admet-194	41	18	alternatively	alternatively	ADV
admet-194	41	19	,	,	PUNCT
admet-194	41	20	aβ	aβ	PRON
admet-194	41	21	would	would	AUX
admet-194	41	22	not	not	PART
admet-194	41	23	be	be	AUX
admet-194	41	24	generated	generate	VERB
admet-194	41	25	if	if	SCONJ
admet-194	41	26	app	app	PROPN
admet-194	41	27	is	be	AUX
admet-194	41	28	cleaved	cleave	VERB
admet-194	41	29	by	by	ADP
admet-194	41	30	the	the	DET
admet-194	41	31	α	α	NOUN
admet-194	41	32	-	-	NOUN
admet-194	41	33	secretase	secretase	NOUN
admet-194	41	34	,	,	PUNCT
admet-194	41	35	and	and	CCONJ
admet-194	41	36	another	another	DET
admet-194	41	37	soluble	soluble	ADJ
admet-194	41	38	neurotrophic	neurotrophic	NOUN
admet-194	41	39	,	,	PUNCT
admet-194	41	40	sappα	sappα	NOUN
admet-194	41	41	is	be	AUX
admet-194	41	42	the	the	DET
admet-194	41	43	hydrolysis	hydrolysis	NOUN
admet-194	41	44	product	product	NOUN
admet-194	41	45	in	in	ADP
admet-194	41	46	this	this	DET
admet-194	41	47	case	case	NOUN
admet-194	42	1	[	[	X
admet-194	42	2	17	17	NUM
admet-194	42	3	]	]	PUNCT
admet-194	42	4	.	.	PUNCT
admet-194	43	1	details	detail	NOUN
admet-194	43	2	are	be	AUX
admet-194	43	3	shown	show	VERB
admet-194	43	4	in	in	ADP
admet-194	43	5	figure	figure	NOUN
admet-194	43	6	1	1	NUM
admet-194	43	7	.	.	PUNCT
admet-194	44	1	however	however	ADV
admet-194	44	2	,	,	PUNCT
admet-194	44	3	due	due	ADP
admet-194	44	4	to	to	ADP
admet-194	44	5	the	the	DET
admet-194	44	6	high	high	ADJ
admet-194	44	7	expression	expression	NOUN
admet-194	44	8	level	level	NOUN
admet-194	44	9	of	of	ADP
admet-194	44	10	β	β	NOUN
admet-194	44	11	-	-	NOUN
admet-194	44	12	secretase	secretase	NOUN
admet-194	44	13	,	,	PUNCT
admet-194	44	14	amyloidogenic	amyloidogenic	ADJ
admet-194	44	15	pathway	pathway	NOUN
admet-194	44	16	is	be	AUX
admet-194	44	17	more	more	ADV
admet-194	44	18	likely	likely	ADJ
admet-194	44	19	to	to	PART
admet-194	44	20	occur	occur	VERB
admet-194	44	21	than	than	ADP
admet-194	44	22	nonamyloidogenic	nonamyloidogenic	ADJ
admet-194	44	23	pathway	pathway	NOUN
admet-194	44	24	in	in	ADP
admet-194	44	25	neurons	neuron	NOUN
admet-194	44	26	[	[	X
admet-194	44	27	18	18	NUM
admet-194	44	28	]	]	PUNCT
admet-194	44	29	.	.	PUNCT
admet-194	45	1	aβ	aβ	PRON
admet-194	45	2	isoforms	isoform	NOUN
admet-194	45	3	are	be	AUX
admet-194	45	4	proteins	protein	NOUN
admet-194	45	5	containing	contain	VERB
admet-194	45	6	36	36	NUM
admet-194	45	7	-	-	SYM
admet-194	45	8	43	43	NUM
admet-194	45	9	amino	amino	NOUN
admet-194	45	10	acid	acid	NOUN
admet-194	45	11	residues	residue	NOUN
admet-194	45	12	,	,	PUNCT
admet-194	45	13	where	where	SCONJ
admet-194	45	14	aβ40	aβ40	PROPN
admet-194	45	15	and	and	CCONJ
admet-194	45	16	aβ42	aβ42	PROPN
admet-194	45	17	are	be	AUX
admet-194	45	18	the	the	DET
admet-194	45	19	two	two	NUM
admet-194	45	20	major	major	ADJ
admet-194	45	21	isoforms	isoform	NOUN
admet-194	45	22	.	.	PUNCT
admet-194	46	1	aβ42	aβ42	NOUN
admet-194	46	2	is	be	AUX
admet-194	46	3	predominant	predominant	ADJ
admet-194	46	4	in	in	ADP
admet-194	46	5	the	the	DET
admet-194	46	6	brain	brain	NOUN
admet-194	46	7	parenchyma	parenchyma	NOUN
admet-194	46	8	of	of	ADP
admet-194	46	9	ad	ad	NOUN
admet-194	46	10	patients	patient	NOUN
admet-194	46	11	,	,	PUNCT
admet-194	46	12	which	which	PRON
admet-194	46	13	may	may	AUX
admet-194	46	14	result	result	VERB
admet-194	46	15	from	from	ADP
admet-194	46	16	fibrillogenic	fibrillogenic	ADJ
admet-194	46	17	feature	feature	NOUN
admet-194	46	18	.	.	PUNCT
admet-194	47	1	if	if	SCONJ
admet-194	47	2	aβ	aβ	DET
admet-194	47	3	cascade	cascade	NOUN
admet-194	47	4	is	be	AUX
admet-194	47	5	chosen	choose	VERB
admet-194	47	6	as	as	ADP
admet-194	47	7	therapeutic	therapeutic	ADJ
admet-194	47	8	target	target	NOUN
admet-194	47	9	,	,	PUNCT
admet-194	47	10	four	four	NUM
admet-194	47	11	main	main	ADJ
admet-194	47	12	options	option	NOUN
admet-194	47	13	seem	seem	VERB
admet-194	47	14	to	to	PART
admet-194	47	15	be	be	AUX
admet-194	47	16	feasible	feasible	ADJ
admet-194	47	17	to	to	PART
admet-194	47	18	tackle	tackle	VERB
admet-194	47	19	the	the	DET
admet-194	47	20	problem	problem	NOUN
admet-194	47	21	:	:	PUNCT
admet-194	47	22	(	(	PUNCT
admet-194	47	23	1	1	X
admet-194	47	24	)	)	PUNCT
admet-194	47	25	suppression	suppression	NOUN
admet-194	47	26	of	of	ADP
admet-194	47	27	aβ	aβ	DET
admet-194	47	28	production	production	NOUN
admet-194	47	29	,	,	PUNCT
admet-194	47	30	(	(	PUNCT
admet-194	47	31	2	2	NUM
admet-194	47	32	)	)	PUNCT
admet-194	47	33	stimulation	stimulation	NOUN
admet-194	47	34	of	of	ADP
admet-194	47	35	aβ	aβ	DET
admet-194	47	36	clearance	clearance	NOUN
admet-194	47	37	,	,	PUNCT
admet-194	47	38	(	(	PUNCT
admet-194	47	39	3	3	X
admet-194	47	40	)	)	PUNCT
admet-194	47	41	prevention	prevention	NOUN
admet-194	47	42	of	of	ADP
admet-194	47	43	aβ	aβ	PRON
admet-194	47	44	aggregation	aggregation	NOUN
admet-194	47	45	into	into	ADP
admet-194	47	46	amyloid	amyloid	NOUN
admet-194	47	47	plaques	plaque	NOUN
admet-194	47	48	,	,	PUNCT
admet-194	47	49	and	and	CCONJ
admet-194	47	50	(	(	PUNCT
admet-194	47	51	4	4	X
admet-194	47	52	)	)	PUNCT
admet-194	47	53	raising	raise	VERB
admet-194	47	54	brain	brain	NOUN
admet-194	47	55	resistance	resistance	NOUN
admet-194	47	56	to	to	ADP
admet-194	47	57	aβ	aβ	PRON
admet-194	47	58	[	[	X
admet-194	47	59	1	1	NUM
admet-194	47	60	,	,	PUNCT
admet-194	47	61	13	13	NUM
admet-194	47	62	]	]	PUNCT
admet-194	47	63	.	.	PUNCT
admet-194	48	1	figure	figure	NOUN
admet-194	48	2	1	1	NUM
admet-194	48	3	.	.	PUNCT
admet-194	49	1	aβ	aβ	NOUN
admet-194	49	2	cascade	cascade	NOUN
admet-194	49	3	and	and	CCONJ
admet-194	49	4	tau	tau	PROPN
admet-194	49	5	process	process	NOUN
admet-194	49	6	:	:	PUNCT
admet-194	49	7	(	(	PUNCT
admet-194	49	8	a	a	X
admet-194	49	9	)	)	PUNCT
admet-194	49	10	amyloidogenic	amyloidogenic	ADJ
admet-194	49	11	pathway	pathway	NOUN
admet-194	49	12	of	of	ADP
admet-194	49	13	app	app	NOUN
admet-194	49	14	proteolysis	proteolysis	NOUN
admet-194	49	15	,	,	PUNCT
admet-194	49	16	(	(	PUNCT
admet-194	49	17	b	b	X
admet-194	49	18	)	)	PUNCT
admet-194	49	19	non	non	ADJ
admet-194	49	20	-	-	ADJ
admet-194	49	21	amyloidogenic	amyloidogenic	ADJ
admet-194	49	22	pathway	pathway	NOUN
admet-194	49	23	of	of	ADP
admet-194	49	24	app	app	NOUN
admet-194	49	25	processing	processing	NOUN
admet-194	49	26	,	,	PUNCT
admet-194	49	27	(	(	PUNCT
admet-194	49	28	c	c	NOUN
admet-194	49	29	)	)	PUNCT
admet-194	49	30	interaction	interaction	NOUN
admet-194	49	31	between	between	ADP
admet-194	49	32	aβ	aβ	NOUN
admet-194	49	33	cascade	cascade	NOUN
admet-194	49	34	and	and	CCONJ
admet-194	49	35	tau	tau	PROPN
admet-194	49	36	process	process	NOUN
admet-194	49	37	,	,	PUNCT
admet-194	49	38	(	(	PUNCT
admet-194	49	39	d	d	X
admet-194	49	40	)	)	PUNCT
admet-194	49	41	tau	tau	NOUN
admet-194	49	42	process	process	NOUN
admet-194	49	43	.	.	PUNCT
admet-194	50	1	2.1.1.1	2.1.1.1	NUM
admet-194	50	2	three	three	NUM
admet-194	50	3	strategies	strategy	NOUN
admet-194	50	4	of	of	ADP
admet-194	50	5	decreasing	decrease	VERB
admet-194	50	6	aβ	aβ	DET
admet-194	50	7	production	production	NOUN
admet-194	50	8	the	the	DET
admet-194	50	9	extracellular	extracellular	ADJ
admet-194	50	10	accumulation	accumulation	NOUN
admet-194	50	11	of	of	ADP
admet-194	50	12	senile	senile	ADJ
admet-194	50	13	plaques	plaque	NOUN
admet-194	50	14	composes	compose	VERB
admet-194	50	15	of	of	ADP
admet-194	50	16	the	the	DET
admet-194	50	17	aβ	aβ	NOUN
admet-194	50	18	peptide	peptide	NOUN
admet-194	50	19	,	,	PUNCT
admet-194	50	20	which	which	PRON
admet-194	50	21	represents	represent	VERB
admet-194	50	22	one	one	NUM
admet-194	50	23	of	of	ADP
admet-194	50	24	the	the	DET
admet-194	50	25	two	two	NUM
admet-194	50	26	defining	define	VERB
admet-194	50	27	lesions	lesion	NOUN
admet-194	50	28	in	in	ADP
admet-194	50	29	ad	ad	NOUN
admet-194	50	30	brain	brain	NOUN
admet-194	50	31	.	.	PUNCT
admet-194	51	1	as	as	ADP
admet-194	51	2	a	a	DET
admet-194	51	3	vital	vital	ADJ
admet-194	51	4	step	step	NOUN
admet-194	51	5	of	of	ADP
admet-194	51	6	ad	ad	NOUN
admet-194	51	7	pathogenesis	pathogenesis	NOUN
admet-194	51	8	,	,	PUNCT
admet-194	51	9	aβ	aβ	DET
admet-194	51	10	production	production	NOUN
admet-194	51	11	is	be	AUX
admet-194	51	12	a	a	DET
admet-194	51	13	potentially	potentially	ADV
admet-194	51	14	crucial	crucial	ADJ
admet-194	51	15	target	target	NOUN
admet-194	51	16	for	for	ADP
admet-194	51	17	disease	disease	NOUN
admet-194	51	18	-	-	PUNCT
admet-194	51	19	modifying	modify	VERB
admet-194	51	20	therapeutic	therapeutic	ADJ
admet-194	51	21	methods	method	NOUN
admet-194	51	22	which	which	PRON
admet-194	51	23	attempt	attempt	VERB
admet-194	51	24	to	to	PART
admet-194	51	25	restrain	restrain	VERB
admet-194	51	26	the	the	DET
admet-194	51	27	disease	disease	NOUN
admet-194	51	28	at	at	ADP
admet-194	51	29	early	early	ADJ
admet-194	51	30	stages	stage	NOUN
admet-194	52	1	[	[	X
admet-194	52	2	12,19	12,19	NOUN
admet-194	52	3	]	]	PUNCT
admet-194	52	4	.	.	PUNCT
admet-194	53	1	2.1.1.1.1	2.1.1.1.1	NUM
admet-194	53	2	β	β	X
admet-194	53	3	-	-	NOUN
admet-194	53	4	secretase	secretase	NOUN
admet-194	53	5	inhibition	inhibition	VERB
admet-194	53	6	β	β	X
admet-194	53	7	-	-	NOUN
admet-194	53	8	secretase	secretase	NOUN
admet-194	53	9	is	be	AUX
admet-194	53	10	an	an	DET
admet-194	53	11	obvious	obvious	ADJ
admet-194	53	12	therapeutic	therapeutic	ADJ
admet-194	53	13	target	target	NOUN
admet-194	53	14	because	because	SCONJ
admet-194	53	15	it	it	PRON
admet-194	53	16	initiates	initiate	VERB
admet-194	53	17	the	the	DET
admet-194	53	18	amyloidogenic	amyloidogenic	ADJ
admet-194	53	19	processing	processing	NOUN
admet-194	53	20	.	.	PUNCT
admet-194	54	1	however	however	ADV
admet-194	54	2	,	,	PUNCT
admet-194	54	3	the	the	DET
admet-194	54	4	development	development	NOUN
admet-194	54	5	of	of	ADP
admet-194	54	6	β	β	NOUN
admet-194	54	7	-	-	ADJ
admet-194	54	8	secretase	secretase	ADJ
admet-194	54	9	inhibitors	inhibitor	NOUN
admet-194	54	10	does	do	AUX
admet-194	54	11	not	not	PART
admet-194	54	12	appear	appear	VERB
admet-194	54	13	to	to	PART
admet-194	54	14	be	be	AUX
admet-194	54	15	straight	straight	ADV
admet-194	54	16	forward	forward	ADV
admet-194	54	17	since	since	SCONJ
admet-194	54	18	the	the	DET
admet-194	54	19	physiological	physiological	ADJ
admet-194	54	20	roles	role	NOUN
admet-194	54	21	and	and	CCONJ
admet-194	54	22	functions	function	NOUN
admet-194	54	23	of	of	ADP
admet-194	54	24	this	this	DET
admet-194	54	25	enzyme	enzyme	NOUN
admet-194	54	26	are	be	AUX
admet-194	54	27	not	not	PART
admet-194	54	28	fully	fully	ADV
admet-194	54	29	understood	understand	VERB
admet-194	54	30	[	[	X
admet-194	54	31	20	20	NUM
admet-194	54	32	]	]	PUNCT
admet-194	54	33	.	.	PUNCT
admet-194	55	1	besides	besides	SCONJ
admet-194	55	2	,	,	PUNCT
admet-194	55	3	it	it	PRON
admet-194	55	4	could	could	AUX
admet-194	55	5	be	be	AUX
admet-194	55	6	challenging	challenge	VERB
admet-194	55	7	to	to	PART
admet-194	55	8	develop	develop	VERB
admet-194	55	9	a	a	DET
admet-194	55	10	blood	blood	NOUN
admet-194	55	11	brain	brain	NOUN
admet-194	55	12	barrier	barrier	NOUN
admet-194	55	13	permeable	permeable	ADJ
admet-194	55	14	drug	drug	NOUN
admet-194	55	15	which	which	PRON
admet-194	55	16	can	can	AUX
admet-194	55	17	bind	bind	VERB
admet-194	55	18	effectively	effectively	ADV
admet-194	55	19	to	to	ADP
admet-194	55	20	the	the	DET
admet-194	55	21	large	large	ADJ
admet-194	55	22	catalytic	catalytic	ADJ
admet-194	55	23	pocket	pocket	NOUN
admet-194	55	24	of	of	ADP
admet-194	55	25	the	the	DET
admet-194	55	26	enzyme	enzyme	NOUN
admet-194	55	27	.	.	PUNCT
admet-194	56	1	the	the	DET
admet-194	56	2	oral	oral	ADJ
admet-194	56	3	drugs	drug	NOUN
admet-194	56	4	for	for	ADP
admet-194	56	5	type	type	NOUN
admet-194	56	6	2	2	NUM
admet-194	56	7	diabetes	diabetes	NOUN
admet-194	56	8	,	,	PUNCT
admet-194	56	9	rosiglitazone	rosiglitazone	NOUN
admet-194	56	10	and	and	CCONJ
admet-194	56	11	pioglitazone	pioglitazone	NOUN
admet-194	56	12	show	show	VERB
admet-194	56	13	the	the	DET
admet-194	56	14	ability	ability	NOUN
admet-194	56	15	to	to	PART
admet-194	56	16	inhibit	inhibit	VERB
admet-194	56	17	β	β	NOUN
admet-194	56	18	-	-	NOUN
admet-194	56	19	secretase	secretase	NOUN
admet-194	56	20	by	by	ADP
admet-194	56	21	activating	activate	VERB
admet-194	56	22	the	the	DET
admet-194	56	23	peroxisome	peroxisome	NOUN
admet-194	56	24	-	-	PUNCT
admet-194	56	25	proliferator	proliferator	NOUN
admet-194	56	26	activated	activate	VERB
admet-194	56	27	receptor	receptor	NOUN
admet-194	56	28	-	-	PUNCT
admet-194	56	29	γ	γ	NOUN
admet-194	56	30	(	(	PUNCT
admet-194	56	31	pparγ	pparγ	NOUN
admet-194	56	32	)	)	PUNCT
admet-194	56	33	,	,	PUNCT
admet-194	56	34	which	which	PRON
admet-194	56	35	can	can	AUX
admet-194	56	36	suppress	suppress	VERB
admet-194	56	37	the	the	DET
admet-194	56	38	expression	expression	NOUN
admet-194	56	39	of	of	ADP
admet-194	56	40	app	app	NOUN
admet-194	56	41	and	and	CCONJ
admet-194	56	42	β	β	NOUN
admet-194	56	43	-	-	NOUN
admet-194	56	44	secretase	secretase	NOUN
admet-194	56	45	[	[	X
admet-194	56	46	21	21	NUM
admet-194	56	47	]	]	PUNCT
admet-194	56	48	.	.	PUNCT
admet-194	57	1	rosiglitazone	rosiglitazone	NOUN
admet-194	57	2	has	have	AUX
admet-194	57	3	been	be	AUX
admet-194	57	4	studied	study	VERB
admet-194	57	5	in	in	ADP
admet-194	57	6	a	a	DET
admet-194	57	7	large	large	ADJ
admet-194	57	8	phase	phase	NOUN
admet-194	57	9	3	3	NUM
admet-194	57	10	trial	trial	NOUN
admet-194	57	11	with	with	ADP
admet-194	57	12	ad	ad	NOUN
admet-194	57	13	patients	patient	NOUN
admet-194	57	14	,	,	PUNCT
admet-194	57	15	but	but	CCONJ
admet-194	57	16	the	the	DET
admet-194	57	17	admet	admet	PROPN
admet-194	57	18	&	&	CCONJ
admet-194	57	19	dmpk	dmpk	PROPN
admet-194	57	20	3(3	3(3	NUM
admet-194	57	21	)	)	PUNCT
admet-194	57	22	(	(	PUNCT
admet-194	57	23	2015	2015	NUM
admet-194	57	24	)	)	PUNCT
admet-194	57	25	216	216	NUM
admet-194	57	26	-	-	SYM
admet-194	57	27	234	234	NUM
admet-194	57	28	chemical	chemical	NOUN
admet-194	57	29	and	and	CCONJ
admet-194	57	30	physical	physical	ADJ
admet-194	57	31	approaches	approach	NOUN
admet-194	57	32	for	for	ADP
admet-194	57	33	the	the	DET
admet-194	57	34	treatment	treatment	NOUN
admet-194	57	35	of	of	ADP
admet-194	57	36	ad	ad	NOUN
admet-194	57	37	doi	doi	NOUN
admet-194	57	38	:	:	PUNCT
admet-194	57	39	10.5599	10.5599	NUM
admet-194	57	40	/	/	SYM
admet-194	57	41	admet.3.3.194	admet.3.3.194	PROPN
admet-194	57	42	219	219	NUM
admet-194	57	43	result	result	NOUN
admet-194	57	44	was	be	AUX
admet-194	57	45	negative	negative	ADJ
admet-194	57	46	[	[	X
admet-194	57	47	22	22	NUM
admet-194	57	48	]	]	PUNCT
admet-194	57	49	.	.	PUNCT
admet-194	58	1	and	and	CCONJ
admet-194	58	2	it	it	PRON
admet-194	58	3	is	be	AUX
admet-194	58	4	also	also	ADV
admet-194	58	5	warned	warn	VERB
admet-194	58	6	by	by	ADP
admet-194	58	7	fda	fda	PROPN
admet-194	58	8	that	that	SCONJ
admet-194	58	9	rosiglitazone	rosiglitazone	NOUN
admet-194	58	10	may	may	AUX
admet-194	58	11	be	be	AUX
admet-194	58	12	associated	associate	VERB
admet-194	58	13	with	with	ADP
admet-194	58	14	cardiac	cardiac	ADJ
admet-194	58	15	risks	risk	NOUN
admet-194	58	16	.	.	PUNCT
admet-194	59	1	pioglitazone	pioglitazone	NOUN
admet-194	59	2	exhibited	exhibit	VERB
admet-194	59	3	its	its	PRON
admet-194	59	4	therapeutic	therapeutic	ADJ
admet-194	59	5	effect	effect	NOUN
admet-194	59	6	of	of	ADP
admet-194	59	7	cognitive	cognitive	ADJ
admet-194	59	8	and	and	CCONJ
admet-194	59	9	functional	functional	ADJ
admet-194	59	10	improvements	improvement	NOUN
admet-194	59	11	,	,	PUNCT
admet-194	59	12	and	and	CCONJ
admet-194	59	13	the	the	DET
admet-194	59	14	effect	effect	NOUN
admet-194	59	15	of	of	ADP
admet-194	59	16	disease	disease	NOUN
admet-194	59	17	stabilization	stabilization	NOUN
admet-194	59	18	in	in	ADP
admet-194	59	19	diabetic	diabetic	ADJ
admet-194	59	20	patients	patient	NOUN
admet-194	59	21	with	with	ADP
admet-194	59	22	ad	ad	NOUN
admet-194	59	23	in	in	ADP
admet-194	59	24	a	a	DET
admet-194	59	25	japanese	japanese	ADJ
admet-194	59	26	open	open	ADJ
admet-194	59	27	-	-	PUNCT
admet-194	59	28	label	label	NOUN
admet-194	59	29	study	study	NOUN
admet-194	59	30	[	[	X
admet-194	59	31	23	23	NUM
admet-194	59	32	]	]	PUNCT
admet-194	59	33	.	.	PUNCT
admet-194	60	1	and	and	CCONJ
admet-194	60	2	one	one	NUM
admet-194	60	3	phase	phase	NOUN
admet-194	60	4	2	2	NUM
admet-194	60	5	study	study	NOUN
admet-194	60	6	showed	show	VERB
admet-194	60	7	no	no	DET
admet-194	60	8	unanticipated	unanticipated	ADJ
admet-194	60	9	or	or	CCONJ
admet-194	60	10	serious	serious	ADJ
admet-194	60	11	adverse	adverse	ADJ
admet-194	60	12	events	event	NOUN
admet-194	60	13	attributable	attributable	ADJ
admet-194	60	14	to	to	ADP
admet-194	60	15	pioglitazone	pioglitazone	NOUN
admet-194	60	16	over	over	ADP
admet-194	60	17	a	a	DET
admet-194	60	18	long	long	ADJ
admet-194	60	19	-	-	PUNCT
admet-194	60	20	term	term	NOUN
admet-194	60	21	exposure	exposure	NOUN
admet-194	60	22	in	in	ADP
admet-194	60	23	nondiabetic	nondiabetic	ADJ
admet-194	60	24	patients	patient	NOUN
admet-194	60	25	with	with	ADP
admet-194	60	26	ad	ad	NOUN
admet-194	60	27	,	,	PUNCT
admet-194	60	28	though	though	SCONJ
admet-194	60	29	no	no	DET
admet-194	60	30	significant	significant	ADJ
admet-194	60	31	treatment	treatment	NOUN
admet-194	60	32	effect	effect	NOUN
admet-194	60	33	was	be	AUX
admet-194	60	34	observed	observe	VERB
admet-194	60	35	[	[	X
admet-194	60	36	24	24	NUM
admet-194	60	37	]	]	PUNCT
admet-194	60	38	.	.	PUNCT
admet-194	61	1	an	an	DET
admet-194	61	2	ongoing	ongoing	ADJ
admet-194	61	3	phase	phase	NOUN
admet-194	61	4	3	3	NUM
admet-194	61	5	trial	trial	NOUN
admet-194	61	6	(	(	PUNCT
admet-194	61	7	5,800	5,800	NUM
admet-194	61	8	cognitively	cognitively	ADV
admet-194	61	9	normal	normal	ADJ
admet-194	61	10	participants	participant	NOUN
admet-194	61	11	in	in	ADP
admet-194	61	12	the	the	DET
admet-194	61	13	united	united	PROPN
admet-194	61	14	states	states	PROPN
admet-194	61	15	,	,	PUNCT
admet-194	61	16	australia	australia	PROPN
admet-194	61	17	,	,	PUNCT
admet-194	61	18	europe	europe	PROPN
admet-194	61	19	,	,	PUNCT
admet-194	61	20	and	and	CCONJ
admet-194	61	21	russia	russia	PROPN
admet-194	61	22	)	)	PUNCT
admet-194	61	23	is	be	AUX
admet-194	61	24	underway	underway	ADJ
admet-194	61	25	to	to	PART
admet-194	61	26	evaluate	evaluate	VERB
admet-194	61	27	pioglitazone	pioglitazone	NOUN
admet-194	61	28	's	's	PART
admet-194	61	29	ability	ability	NOUN
admet-194	61	30	to	to	PART
admet-194	61	31	delay	delay	VERB
admet-194	61	32	this	this	DET
admet-194	61	33	diagnosis	diagnosis	NOUN
admet-194	61	34	in	in	ADP
admet-194	61	35	people	people	NOUN
admet-194	61	36	deemed	deem	VERB
admet-194	61	37	high	high	ADJ
admet-194	61	38	-	-	PUNCT
admet-194	61	39	risk	risk	NOUN
admet-194	61	40	with	with	ADP
admet-194	61	41	ad	ad	NOUN
admet-194	61	42	[	[	X
admet-194	61	43	25	25	NUM
admet-194	61	44	]	]	PUNCT
admet-194	61	45	.	.	PUNCT
admet-194	62	1	another	another	DET
admet-194	62	2	β	β	X
admet-194	62	3	-	-	ADJ
admet-194	62	4	secretase	secretase	ADJ
admet-194	62	5	inhibitor	inhibitor	NOUN
admet-194	62	6	,	,	PUNCT
admet-194	62	7	cts-21166	cts-21166	NOUN
admet-194	62	8	has	have	AUX
admet-194	62	9	been	be	AUX
admet-194	62	10	evaluated	evaluate	VERB
admet-194	62	11	in	in	ADP
admet-194	62	12	a	a	DET
admet-194	62	13	phase	phase	NOUN
admet-194	62	14	1	1	NUM
admet-194	62	15	study	study	NOUN
admet-194	62	16	.	.	PUNCT
admet-194	63	1	preliminary	preliminary	ADJ
admet-194	63	2	clinical	clinical	ADJ
admet-194	63	3	results	result	NOUN
admet-194	63	4	suggested	suggest	VERB
admet-194	63	5	that	that	SCONJ
admet-194	63	6	this	this	DET
admet-194	63	7	inhibitor	inhibitor	NOUN
admet-194	63	8	was	be	AUX
admet-194	63	9	able	able	ADJ
admet-194	63	10	to	to	PART
admet-194	63	11	reduce	reduce	VERB
admet-194	63	12	the	the	DET
admet-194	63	13	aβ	aβ	PROPN
admet-194	63	14	levels	level	NOUN
admet-194	63	15	in	in	ADP
admet-194	63	16	human	human	ADJ
admet-194	63	17	plasma	plasma	NOUN
admet-194	64	1	[	[	X
admet-194	64	2	26	26	NUM
admet-194	64	3	]	]	PUNCT
admet-194	64	4	.	.	PUNCT
admet-194	65	1	other	other	ADJ
admet-194	65	2	βsecretase	βsecretase	NOUN
admet-194	65	3	inhibitors	inhibitor	NOUN
admet-194	65	4	such	such	ADJ
admet-194	65	5	as	as	ADP
admet-194	65	6	gsk188909	gsk188909	ADJ
admet-194	65	7	and	and	CCONJ
admet-194	65	8	pms777	pms777	PROPN
admet-194	65	9	have	have	AUX
admet-194	65	10	been	be	AUX
admet-194	65	11	reported	report	VERB
admet-194	65	12	to	to	PART
admet-194	65	13	reduce	reduce	VERB
admet-194	65	14	the	the	DET
admet-194	65	15	level	level	NOUN
admet-194	65	16	of	of	ADP
admet-194	65	17	aβ42	aβ42	PROPN
admet-194	65	18	in	in	ADP
admet-194	65	19	vitro	vitro	X
admet-194	65	20	[	[	X
admet-194	65	21	27	27	NUM
admet-194	65	22	,	,	PUNCT
admet-194	65	23	28	28	NUM
admet-194	65	24	]	]	PUNCT
admet-194	65	25	,	,	PUNCT
admet-194	65	26	but	but	CCONJ
admet-194	65	27	no	no	DET
admet-194	65	28	clinical	clinical	ADJ
admet-194	65	29	trial	trial	NOUN
admet-194	65	30	is	be	AUX
admet-194	65	31	conducted	conduct	VERB
admet-194	65	32	now	now	ADV
admet-194	65	33	.	.	PUNCT
admet-194	66	1	with	with	ADP
admet-194	66	2	more	more	ADV
admet-194	66	3	promising	promising	ADJ
admet-194	66	4	β	β	X
admet-194	66	5	-	-	ADJ
admet-194	66	6	secretase	secretase	ADJ
admet-194	66	7	inhibitors	inhibitor	NOUN
admet-194	66	8	come	come	VERB
admet-194	66	9	to	to	ADP
admet-194	66	10	the	the	DET
admet-194	66	11	horizon	horizon	NOUN
admet-194	66	12	,	,	PUNCT
admet-194	66	13	it	it	PRON
admet-194	66	14	is	be	AUX
admet-194	66	15	expected	expect	VERB
admet-194	66	16	that	that	SCONJ
admet-194	66	17	some	some	PRON
admet-194	66	18	of	of	ADP
admet-194	66	19	them	they	PRON
admet-194	66	20	might	might	AUX
admet-194	66	21	be	be	AUX
admet-194	66	22	developed	develop	VERB
admet-194	66	23	into	into	ADP
admet-194	66	24	candidate	candidate	NOUN
admet-194	66	25	drugs	drug	NOUN
admet-194	66	26	showing	show	VERB
admet-194	66	27	positive	positive	ADJ
admet-194	66	28	indications	indication	NOUN
admet-194	66	29	in	in	ADP
admet-194	66	30	future	future	ADJ
admet-194	66	31	clinical	clinical	ADJ
admet-194	66	32	evaluations	evaluation	NOUN
admet-194	66	33	for	for	ADP
admet-194	66	34	the	the	DET
admet-194	66	35	modulation	modulation	NOUN
admet-194	66	36	of	of	ADP
admet-194	66	37	cognitive	cognitive	ADJ
admet-194	66	38	decline	decline	NOUN
admet-194	66	39	in	in	ADP
admet-194	66	40	ad	ad	NOUN
admet-194	66	41	patients	patient	NOUN
admet-194	66	42	[	[	X
admet-194	66	43	29	29	NUM
admet-194	66	44	]	]	PUNCT
admet-194	66	45	.	.	PUNCT
admet-194	67	1	2.1.1.1.2	2.1.1.1.2	NUM
admet-194	67	2	γ	γ	X
admet-194	67	3	-	-	PUNCT
admet-194	67	4	secretase	secretase	ADJ
admet-194	67	5	modulation	modulation	NOUN
admet-194	67	6	/	/	SYM
admet-194	67	7	inhibition	inhibition	NOUN
admet-194	67	8	similar	similar	ADJ
admet-194	67	9	to	to	ADP
admet-194	67	10	β	β	NOUN
admet-194	67	11	-	-	NOUN
admet-194	67	12	secretase	secretase	NOUN
admet-194	67	13	,	,	PUNCT
admet-194	67	14	γ	γ	PROPN
admet-194	67	15	-	-	PUNCT
admet-194	67	16	secretase	secretase	NOUN
admet-194	67	17	also	also	ADV
admet-194	67	18	has	have	VERB
admet-194	67	19	many	many	ADJ
admet-194	67	20	other	other	ADJ
admet-194	67	21	substrates	substrate	NOUN
admet-194	67	22	besides	besides	SCONJ
admet-194	67	23	app	app	PROPN
admet-194	67	24	,	,	PUNCT
admet-194	67	25	including	include	VERB
admet-194	67	26	the	the	DET
admet-194	67	27	notch	notch	ADJ
admet-194	67	28	receptor	receptor	NOUN
admet-194	67	29	and	and	CCONJ
admet-194	67	30	other	other	ADJ
admet-194	67	31	neuronal	neuronal	ADJ
admet-194	67	32	substrates	substrate	NOUN
admet-194	67	33	.	.	PUNCT
admet-194	68	1	notch	notch	ADJ
admet-194	68	2	,	,	PUNCT
admet-194	68	3	involving	involve	VERB
admet-194	68	4	in	in	ADP
admet-194	68	5	cell	cell	NOUN
admet-194	68	6	differentiation	differentiation	NOUN
admet-194	68	7	,	,	PUNCT
admet-194	68	8	is	be	AUX
admet-194	68	9	necessary	necessary	ADJ
admet-194	68	10	for	for	ADP
admet-194	68	11	growth	growth	NOUN
admet-194	68	12	and	and	CCONJ
admet-194	68	13	development	development	NOUN
admet-194	68	14	.	.	PUNCT
admet-194	69	1	the	the	DET
admet-194	69	2	side	side	NOUN
admet-194	69	3	effects	effect	NOUN
admet-194	69	4	of	of	ADP
admet-194	69	5	γ	γ	NOUN
admet-194	69	6	-	-	PUNCT
admet-194	69	7	secretase	secretase	NOUN
admet-194	69	8	inhibition	inhibition	NOUN
admet-194	69	9	which	which	PRON
admet-194	69	10	is	be	AUX
admet-194	69	11	associated	associate	VERB
admet-194	69	12	with	with	ADP
admet-194	69	13	notch	notch	ADJ
admet-194	69	14	(	(	PUNCT
admet-194	69	15	gastrointestinal	gastrointestinal	ADJ
admet-194	69	16	and	and	CCONJ
admet-194	69	17	haematological	haematological	ADJ
admet-194	69	18	toxicity	toxicity	NOUN
admet-194	69	19	,	,	PUNCT
admet-194	69	20	skin	skin	NOUN
admet-194	69	21	cancer	cancer	NOUN
admet-194	69	22	,	,	PUNCT
admet-194	69	23	and	and	CCONJ
admet-194	69	24	changes	change	NOUN
admet-194	69	25	in	in	ADP
admet-194	69	26	hair	hair	NOUN
admet-194	69	27	colour	colour	NOUN
admet-194	69	28	)	)	PUNCT
admet-194	69	29	have	have	AUX
admet-194	69	30	been	be	AUX
admet-194	69	31	hindering	hinder	VERB
admet-194	69	32	the	the	DET
admet-194	69	33	development	development	NOUN
admet-194	69	34	of	of	ADP
admet-194	69	35	γsecretase	γsecretase	ADJ
admet-194	69	36	inhibitors	inhibitor	NOUN
admet-194	69	37	[	[	X
admet-194	69	38	30	30	NUM
admet-194	69	39	]	]	PUNCT
admet-194	69	40	.	.	PUNCT
admet-194	70	1	several	several	ADJ
admet-194	70	2	γ	γ	PROPN
admet-194	70	3	-	-	PUNCT
admet-194	70	4	secretase	secretase	ADJ
admet-194	70	5	inhibitors	inhibitor	NOUN
admet-194	70	6	linked	link	VERB
admet-194	70	7	with	with	ADP
admet-194	70	8	ad	ad	NOUN
admet-194	70	9	,	,	PUNCT
admet-194	70	10	like	like	ADP
admet-194	70	11	semagacestat	semagacestat	NOUN
admet-194	70	12	(	(	PUNCT
admet-194	70	13	ly-450139	ly-450139	PROPN
admet-194	70	14	)	)	PUNCT
admet-194	70	15	,	,	PUNCT
admet-194	70	16	pf-3084014	pf-3084014	NOUN
admet-194	70	17	,	,	PUNCT
admet-194	70	18	avagacestat	avagacestat	NOUN
admet-194	70	19	(	(	PUNCT
admet-194	70	20	bms-708163	bms-708163	NOUN
admet-194	70	21	)	)	PUNCT
admet-194	70	22	,	,	PUNCT
admet-194	70	23	begacestat	begacestat	X
admet-194	70	24	(	(	PUNCT
admet-194	70	25	gsi-953	gsi-953	NOUN
admet-194	70	26	)	)	PUNCT
admet-194	70	27	,	,	PUNCT
admet-194	70	28	and	and	CCONJ
admet-194	70	29	nic5	nic5	PROPN
admet-194	70	30	-	-	PUNCT
admet-194	70	31	15	15	NUM
admet-194	70	32	have	have	AUX
admet-194	70	33	reached	reach	VERB
admet-194	70	34	clinical	clinical	ADJ
admet-194	70	35	trial	trial	NOUN
admet-194	70	36	.	.	PUNCT
admet-194	71	1	semagacestat	semagacestat	PROPN
admet-194	71	2	is	be	AUX
admet-194	71	3	the	the	DET
admet-194	71	4	first	first	ADJ
admet-194	71	5	γsecretase	γsecretase	ADJ
admet-194	71	6	inhibitor	inhibitor	NOUN
admet-194	71	7	to	to	PART
admet-194	71	8	have	have	AUX
admet-194	71	9	been	be	AUX
admet-194	71	10	taken	take	VERB
admet-194	71	11	into	into	ADP
admet-194	71	12	phase	phase	NOUN
admet-194	71	13	3	3	NUM
admet-194	71	14	clinical	clinical	ADJ
admet-194	71	15	trials	trial	NOUN
admet-194	71	16	.	.	PUNCT
admet-194	72	1	however	however	ADV
admet-194	72	2	,	,	PUNCT
admet-194	72	3	the	the	DET
admet-194	72	4	trials	trial	NOUN
admet-194	72	5	were	be	AUX
admet-194	72	6	suspended	suspend	VERB
admet-194	72	7	because	because	SCONJ
admet-194	72	8	of	of	ADP
admet-194	72	9	no	no	DET
admet-194	72	10	efficacy	efficacy	NOUN
admet-194	72	11	on	on	ADP
admet-194	72	12	cognition	cognition	NOUN
admet-194	72	13	or	or	CCONJ
admet-194	72	14	function	function	NOUN
admet-194	72	15	and	and	CCONJ
admet-194	72	16	increased	increase	VERB
admet-194	72	17	risk	risk	NOUN
admet-194	72	18	of	of	ADP
admet-194	72	19	infections	infection	NOUN
admet-194	72	20	and	and	CCONJ
admet-194	72	21	skin	skin	NOUN
admet-194	72	22	cancer	cancer	NOUN
admet-194	72	23	[	[	X
admet-194	72	24	31	31	NUM
admet-194	72	25	]	]	PUNCT
admet-194	72	26	.	.	PUNCT
admet-194	73	1	a	a	DET
admet-194	73	2	phase	phase	NOUN
admet-194	73	3	1	1	NUM
admet-194	73	4	clinical	clinical	ADJ
admet-194	73	5	trial	trial	NOUN
admet-194	73	6	with	with	ADP
admet-194	73	7	healthy	healthy	ADJ
admet-194	73	8	subjects	subject	NOUN
admet-194	73	9	showed	show	VERB
admet-194	73	10	that	that	DET
admet-194	73	11	pf-3084014	pf-3084014	NOUN
admet-194	73	12	with	with	ADP
admet-194	73	13	high	high	ADJ
admet-194	73	14	selectivity	selectivity	NOUN
admet-194	73	15	for	for	ADP
admet-194	73	16	app	app	NOUN
admet-194	73	17	had	have	VERB
admet-194	73	18	good	good	ADJ
admet-194	73	19	activity	activity	NOUN
admet-194	73	20	exhibiting	exhibit	VERB
admet-194	73	21	a	a	DET
admet-194	73	22	dose	dose	NOUN
admet-194	73	23	-	-	PUNCT
admet-194	73	24	dependent	dependent	ADJ
admet-194	73	25	decrease	decrease	NOUN
admet-194	73	26	in	in	ADP
admet-194	73	27	plasma	plasma	NOUN
admet-194	73	28	aβ	aβ	NOUN
admet-194	73	29	concentrations	concentration	NOUN
admet-194	73	30	,	,	PUNCT
admet-194	73	31	though	though	SCONJ
admet-194	73	32	its	its	PRON
admet-194	73	33	effects	effect	NOUN
admet-194	73	34	on	on	ADP
admet-194	73	35	cerebrospinal	cerebrospinal	ADJ
admet-194	73	36	fluid	fluid	NOUN
admet-194	73	37	(	(	PUNCT
admet-194	73	38	csf	csf	NOUN
admet-194	73	39	)	)	PUNCT
admet-194	73	40	were	be	AUX
admet-194	73	41	low	low	ADJ
admet-194	73	42	[	[	X
admet-194	73	43	32	32	NUM
admet-194	73	44	]	]	PUNCT
admet-194	73	45	.	.	PUNCT
admet-194	74	1	avagacestat	avagacestat	PROPN
admet-194	74	2	,	,	PUNCT
admet-194	74	3	begacestat	begacestat	NOUN
admet-194	74	4	and	and	CCONJ
admet-194	74	5	nic5	nic5	PROPN
admet-194	74	6	-	-	PUNCT
admet-194	74	7	15	15	NUM
admet-194	74	8	are	be	AUX
admet-194	74	9	notch	notch	ADV
admet-194	74	10	-	-	PUNCT
admet-194	74	11	sparing	spare	VERB
admet-194	74	12	γ	γ	NOUN
admet-194	74	13	-	-	ADJ
admet-194	74	14	secretase	secretase	ADJ
admet-194	74	15	inhibitors	inhibitor	NOUN
admet-194	74	16	,	,	PUNCT
admet-194	74	17	which	which	PRON
admet-194	74	18	can	can	AUX
admet-194	74	19	be	be	AUX
admet-194	74	20	considered	consider	VERB
admet-194	74	21	to	to	PART
admet-194	74	22	have	have	VERB
admet-194	74	23	the	the	DET
admet-194	74	24	effect	effect	NOUN
admet-194	74	25	of	of	ADP
admet-194	74	26	decreasing	decrease	VERB
admet-194	74	27	csf	csf	ADJ
admet-194	74	28	aβ	aβ	NOUN
admet-194	74	29	concentration	concentration	NOUN
admet-194	74	30	without	without	ADP
admet-194	74	31	arousing	arouse	VERB
admet-194	74	32	notch	notch	ADV
admet-194	74	33	-	-	PUNCT
admet-194	74	34	related	relate	VERB
admet-194	74	35	toxicity	toxicity	NOUN
admet-194	74	36	.	.	PUNCT
admet-194	75	1	however	however	ADV
admet-194	75	2	,	,	PUNCT
admet-194	75	3	most	most	ADJ
admet-194	75	4	patients	patient	NOUN
admet-194	75	5	ceased	cease	VERB
admet-194	75	6	the	the	DET
admet-194	75	7	phase	phase	NOUN
admet-194	75	8	2	2	NUM
admet-194	75	9	trials	trial	NOUN
admet-194	75	10	with	with	ADP
admet-194	75	11	avagacestat	avagacestat	NOUN
admet-194	75	12	because	because	SCONJ
admet-194	75	13	of	of	ADP
admet-194	75	14	gastrointestinal	gastrointestinal	ADJ
admet-194	75	15	and	and	CCONJ
admet-194	75	16	dermatological	dermatological	ADJ
admet-194	75	17	side	side	NOUN
admet-194	75	18	effects	effect	NOUN
admet-194	75	19	such	such	ADJ
admet-194	75	20	as	as	ADP
admet-194	75	21	diarrhea	diarrhea	NOUN
admet-194	75	22	,	,	PUNCT
admet-194	75	23	nausea	nausea	NOUN
admet-194	75	24	,	,	PUNCT
admet-194	75	25	vomiting	vomiting	NOUN
admet-194	75	26	,	,	PUNCT
admet-194	75	27	rash	rash	ADJ
admet-194	75	28	,	,	PUNCT
admet-194	75	29	and	and	CCONJ
admet-194	75	30	itching	itching	NOUN
admet-194	75	31	skin	skin	NOUN
admet-194	75	32	,	,	PUNCT
admet-194	75	33	and	and	CCONJ
admet-194	75	34	even	even	ADV
admet-194	75	35	nonmelanoma	nonmelanoma	VERB
admet-194	75	36	skin	skin	NOUN
admet-194	75	37	cancers	cancer	NOUN
admet-194	75	38	[	[	X
admet-194	75	39	33	33	NUM
admet-194	75	40	]	]	PUNCT
admet-194	75	41	.	.	PUNCT
admet-194	76	1	begacestat	begacestat	PROPN
admet-194	76	2	has	have	AUX
admet-194	76	3	been	be	AUX
admet-194	76	4	tested	test	VERB
admet-194	76	5	in	in	ADP
admet-194	76	6	a	a	DET
admet-194	76	7	phase	phase	NOUN
admet-194	76	8	1	1	NUM
admet-194	76	9	trial	trial	NOUN
admet-194	76	10	with	with	ADP
admet-194	76	11	the	the	DET
admet-194	76	12	consequence	consequence	NOUN
admet-194	76	13	of	of	ADP
admet-194	76	14	reducing	reduce	VERB
admet-194	76	15	aβ	aβ	DET
admet-194	76	16	concentrations	concentration	NOUN
admet-194	76	17	in	in	ADP
admet-194	76	18	the	the	DET
admet-194	76	19	plasma	plasma	NOUN
admet-194	76	20	(	(	PUNCT
admet-194	76	21	with	with	ADP
admet-194	76	22	delayed	delay	VERB
admet-194	76	23	rebound	rebound	NOUN
admet-194	76	24	)	)	PUNCT
admet-194	77	1	[	[	X
admet-194	77	2	34	34	NUM
admet-194	77	3	]	]	X
admet-194	77	4	,	,	PUNCT
admet-194	77	5	without	without	ADP
admet-194	77	6	significant	significant	ADJ
admet-194	77	7	reduction	reduction	NOUN
admet-194	77	8	of	of	ADP
admet-194	77	9	csf	csf	ADJ
admet-194	77	10	aβ40	aβ40	PROPN
admet-194	77	11	.	.	PUNCT
admet-194	78	1	nic5	nic5	PROPN
admet-194	78	2	-	-	PUNCT
admet-194	78	3	15	15	NUM
admet-194	78	4	is	be	AUX
admet-194	78	5	a	a	DET
admet-194	78	6	small	small	ADJ
admet-194	78	7	and	and	CCONJ
admet-194	78	8	single	single	ADJ
admet-194	78	9	monosaccharide	monosaccharide	NOUN
admet-194	78	10	exited	exit	VERB
admet-194	78	11	in	in	ADP
admet-194	78	12	soy	soy	NOUN
admet-194	78	13	and	and	CCONJ
admet-194	78	14	other	other	ADJ
admet-194	78	15	plants	plant	NOUN
admet-194	78	16	and	and	CCONJ
admet-194	78	17	fruits	fruit	NOUN
admet-194	78	18	.	.	PUNCT
admet-194	79	1	it	it	PRON
admet-194	79	2	has	have	AUX
admet-194	79	3	been	be	AUX
admet-194	79	4	tested	test	VERB
admet-194	79	5	in	in	ADP
admet-194	79	6	ad	ad	NOUN
admet-194	79	7	patients	patient	NOUN
admet-194	79	8	in	in	ADP
admet-194	79	9	a	a	DET
admet-194	79	10	finished	finished	ADJ
admet-194	79	11	phase	phase	NOUN
admet-194	79	12	2	2	NUM
admet-194	79	13	trial	trial	NOUN
admet-194	79	14	to	to	PART
admet-194	79	15	assess	assess	VERB
admet-194	79	16	its	its	PRON
admet-194	79	17	safety	safety	NOUN
admet-194	79	18	and	and	CCONJ
admet-194	79	19	efficacy	efficacy	NOUN
admet-194	79	20	,	,	PUNCT
admet-194	79	21	and	and	CCONJ
admet-194	79	22	the	the	DET
admet-194	79	23	preliminary	preliminary	ADJ
admet-194	79	24	results	result	NOUN
admet-194	79	25	have	have	AUX
admet-194	79	26	shown	show	VERB
admet-194	79	27	that	that	SCONJ
admet-194	79	28	this	this	DET
admet-194	79	29	compound	compound	NOUN
admet-194	79	30	is	be	AUX
admet-194	79	31	safe	safe	ADJ
admet-194	79	32	and	and	CCONJ
admet-194	79	33	well	well	ADV
admet-194	79	34	tolerated	tolerate	VERB
admet-194	79	35	[	[	PUNCT
admet-194	79	36	35].the	35].the	DET
admet-194	79	37	other	other	ADJ
admet-194	79	38	phase	phase	NOUN
admet-194	79	39	2	2	NUM
admet-194	79	40	trial	trial	NOUN
admet-194	79	41	was	be	AUX
admet-194	79	42	initiated	initiate	VERB
admet-194	79	43	in	in	ADP
admet-194	79	44	2012	2012	NUM
admet-194	79	45	,	,	PUNCT
admet-194	79	46	and	and	CCONJ
admet-194	79	47	no	no	DET
admet-194	79	48	study	study	NOUN
admet-194	79	49	results	result	NOUN
admet-194	79	50	have	have	AUX
admet-194	79	51	been	be	AUX
admet-194	79	52	reported	report	VERB
admet-194	79	53	[	[	X
admet-194	79	54	36	36	NUM
admet-194	79	55	]	]	PUNCT
admet-194	79	56	.	.	PUNCT
admet-194	80	1	with	with	ADP
admet-194	80	2	selective	selective	ADJ
admet-194	80	3	inhibition	inhibition	NOUN
admet-194	80	4	of	of	ADP
admet-194	80	5	app	app	ADJ
admet-194	80	6	proteolysis	proteolysis	NOUN
admet-194	80	7	and	and	CCONJ
admet-194	80	8	no	no	DET
admet-194	80	9	notch	notch	ADV
admet-194	80	10	-	-	PUNCT
admet-194	80	11	based	base	VERB
admet-194	80	12	adverse	adverse	ADJ
admet-194	80	13	effects	effect	NOUN
admet-194	80	14	,	,	PUNCT
admet-194	80	15	γ	γ	NOUN
admet-194	80	16	-	-	PUNCT
admet-194	80	17	secretase	secretase	ADJ
admet-194	80	18	modulators	modulator	NOUN
admet-194	80	19	have	have	AUX
admet-194	80	20	been	be	AUX
admet-194	80	21	given	give	VERB
admet-194	80	22	much	much	ADJ
admet-194	80	23	attention	attention	NOUN
admet-194	80	24	,	,	PUNCT
admet-194	80	25	which	which	PRON
admet-194	80	26	can	can	AUX
admet-194	80	27	shift	shift	VERB
admet-194	80	28	the	the	DET
admet-194	80	29	γ	γ	NOUN
admet-194	80	30	-	-	ADJ
admet-194	80	31	secretase	secretase	ADJ
admet-194	80	32	cleavage	cleavage	NOUN
admet-194	80	33	point	point	NOUN
admet-194	80	34	to	to	PART
admet-194	80	35	obtain	obtain	VERB
admet-194	80	36	nontoxic	nontoxic	ADJ
admet-194	80	37	,	,	PUNCT
admet-194	80	38	shorter	short	ADJ
admet-194	80	39	aβ	aβ	NOUN
admet-194	80	40	isoforms	isoform	NOUN
admet-194	80	41	.	.	PUNCT
admet-194	81	1	several	several	ADJ
admet-194	81	2	non	non	ADJ
admet-194	81	3	-	-	ADJ
admet-194	81	4	steroidal	steroidal	ADJ
admet-194	81	5	anti	anti	ADJ
admet-194	81	6	-	-	ADJ
admet-194	81	7	inflammatory	inflammatory	ADJ
admet-194	81	8	drugs	drug	NOUN
admet-194	81	9	(	(	PUNCT
admet-194	81	10	nsaids	nsaid	NOUN
admet-194	81	11	)	)	PUNCT
admet-194	81	12	were	be	AUX
admet-194	81	13	reported	report	VERB
admet-194	81	14	as	as	ADP
admet-194	81	15	aβ42	aβ42	PROPN
admet-194	81	16	-	-	PUNCT
admet-194	81	17	lowering	lower	VERB
admet-194	81	18	γsecretase	γsecretase	NOUN
admet-194	81	19	modulators	modulator	NOUN
admet-194	81	20	,	,	PUNCT
admet-194	81	21	including	include	VERB
admet-194	81	22	sulindacsulfide	sulindacsulfide	ADV
admet-194	81	23	,	,	PUNCT
admet-194	81	24	indomethacin	indomethacin	NOUN
admet-194	81	25	,	,	PUNCT
admet-194	81	26	and	and	CCONJ
admet-194	81	27	ibuprofen	ibuprofen	NOUN
admet-194	81	28	.	.	PUNCT
admet-194	82	1	they	they	PRON
admet-194	82	2	can	can	AUX
admet-194	82	3	bind	bind	VERB
admet-194	82	4	to	to	ADP
admet-194	82	5	app	app	NOUN
admet-194	82	6	to	to	ADP
admet-194	82	7	jing	jing	PROPN
admet-194	82	8	li	li	PROPN
admet-194	82	9	et	et	PROPN
admet-194	82	10	al	al	PROPN
admet-194	82	11	.	.	PROPN
admet-194	82	12	admet	admet	PROPN
admet-194	82	13	&	&	CCONJ
admet-194	82	14	dmpk	dmpk	PROPN
admet-194	82	15	3(3	3(3	NUM
admet-194	82	16	)	)	PUNCT
admet-194	82	17	(	(	PUNCT
admet-194	82	18	2015	2015	NUM
admet-194	82	19	)	)	PUNCT
admet-194	82	20	216	216	NUM
admet-194	82	21	-	-	SYM
admet-194	82	22	234	234	NUM
admet-194	82	23	220	220	NUM
admet-194	82	24	reduce	reduce	VERB
admet-194	82	25	the	the	DET
admet-194	82	26	generation	generation	NOUN
admet-194	82	27	of	of	ADP
admet-194	82	28	aβ40	aβ40	PROPN
admet-194	82	29	and	and	CCONJ
admet-194	82	30	aβ42	aβ42	PROPN
admet-194	82	31	,	,	PUNCT
admet-194	82	32	and	and	CCONJ
admet-194	82	33	enhance	enhance	VERB
admet-194	82	34	the	the	DET
admet-194	82	35	production	production	NOUN
admet-194	82	36	of	of	ADP
admet-194	82	37	aβ38	aβ38	PROPN
admet-194	82	38	[	[	X
admet-194	82	39	37	37	NUM
admet-194	82	40	]	]	PUNCT
admet-194	82	41	.	.	PUNCT
admet-194	83	1	as	as	ADP
admet-194	83	2	a	a	DET
admet-194	83	3	promising	promising	ADJ
admet-194	83	4	candidate	candidate	NOUN
admet-194	83	5	,	,	PUNCT
admet-194	83	6	tarenflurbil	tarenflurbil	VERB
admet-194	83	7	,	,	PUNCT
admet-194	83	8	the	the	DET
admet-194	83	9	r	r	NOUN
admet-194	83	10	enantiomer	enantiomer	NOUN
admet-194	83	11	of	of	ADP
admet-194	83	12	fluriprofen	fluriprofen	NOUN
admet-194	83	13	,	,	PUNCT
admet-194	83	14	failed	fail	VERB
admet-194	83	15	in	in	ADP
admet-194	83	16	phase	phase	NOUN
admet-194	83	17	3	3	NUM
admet-194	83	18	trial	trial	NOUN
admet-194	83	19	for	for	ADP
admet-194	83	20	ad	ad	NOUN
admet-194	83	21	patients	patient	NOUN
admet-194	83	22	.	.	PUNCT
admet-194	84	1	disappointingly	disappointingly	ADV
admet-194	84	2	,	,	PUNCT
admet-194	84	3	ad	ad	NOUN
admet-194	84	4	patients	patient	NOUN
admet-194	84	5	treated	treat	VERB
admet-194	84	6	with	with	ADP
admet-194	84	7	this	this	DET
admet-194	84	8	compound	compound	NOUN
admet-194	84	9	showed	show	VERB
admet-194	84	10	progressive	progressive	ADJ
admet-194	84	11	deterioration	deterioration	NOUN
admet-194	84	12	in	in	ADP
admet-194	84	13	cognitive	cognitive	ADJ
admet-194	84	14	functions	function	NOUN
admet-194	84	15	and	and	CCONJ
admet-194	84	16	daily	daily	ADJ
admet-194	84	17	activities	activity	NOUN
admet-194	84	18	.	.	PUNCT
admet-194	85	1	this	this	DET
admet-194	85	2	negative	negative	ADJ
admet-194	85	3	result	result	NOUN
admet-194	85	4	might	might	AUX
admet-194	85	5	be	be	AUX
admet-194	85	6	ascribed	ascribe	VERB
admet-194	85	7	to	to	ADP
admet-194	85	8	the	the	DET
admet-194	85	9	low	low	ADJ
admet-194	85	10	γ	γ	ADJ
admet-194	85	11	-	-	ADJ
admet-194	85	12	secretase	secretase	ADJ
admet-194	85	13	modulator	modulator	NOUN
admet-194	85	14	potency	potency	NOUN
admet-194	85	15	and	and	CCONJ
admet-194	85	16	poor	poor	ADJ
admet-194	85	17	cns	cns	NOUN
admet-194	85	18	penetration	penetration	NOUN
admet-194	85	19	[	[	X
admet-194	85	20	38	38	NUM
admet-194	85	21	]	]	PUNCT
admet-194	85	22	.	.	PUNCT
admet-194	86	1	and	and	CCONJ
admet-194	86	2	another	another	DET
admet-194	86	3	compound	compound	NOUN
admet-194	86	4	called	call	VERB
admet-194	86	5	chf-5074	chf-5074	NOUN
admet-194	86	6	showed	show	VERB
admet-194	86	7	antiinflammatory	antiinflammatory	NOUN
admet-194	86	8	benefit	benefit	NOUN
admet-194	86	9	and	and	CCONJ
admet-194	86	10	improvement	improvement	NOUN
admet-194	86	11	of	of	ADP
admet-194	86	12	executive	executive	ADJ
admet-194	86	13	function	function	NOUN
admet-194	86	14	in	in	ADP
admet-194	86	15	phase	phase	NOUN
admet-194	86	16	2	2	NUM
admet-194	86	17	trial	trial	NOUN
admet-194	86	18	,	,	PUNCT
admet-194	86	19	with	with	ADP
admet-194	86	20	adverse	adverse	ADJ
admet-194	86	21	events	event	NOUN
admet-194	86	22	of	of	ADP
admet-194	86	23	mild	mild	ADJ
admet-194	86	24	diarrhoea	diarrhoea	NOUN
admet-194	86	25	,	,	PUNCT
admet-194	86	26	dizziness	dizziness	NOUN
admet-194	86	27	and	and	CCONJ
admet-194	86	28	backache	backache	NOUN
admet-194	86	29	[	[	X
admet-194	86	30	39	39	NUM
admet-194	86	31	]	]	PUNCT
admet-194	86	32	.	.	PUNCT
admet-194	87	1	not	not	PART
admet-194	87	2	unexpectedly	unexpectedly	ADV
admet-194	87	3	,	,	PUNCT
admet-194	87	4	another	another	DET
admet-194	87	5	phase	phase	NOUN
admet-194	87	6	2	2	NUM
admet-194	87	7	trial	trial	NOUN
admet-194	87	8	with	with	ADP
admet-194	87	9	chf-5074	chf-5074	NOUN
admet-194	87	10	was	be	AUX
admet-194	87	11	withdrawn	withdraw	VERB
admet-194	87	12	from	from	ADP
admet-194	87	13	clinicaltrials.gov	clinicaltrials.gov	X
admet-194	87	14	prior	prior	ADV
admet-194	87	15	to	to	ADP
admet-194	87	16	enrolment	enrolment	NOUN
admet-194	87	17	[	[	X
admet-194	87	18	40	40	NUM
admet-194	87	19	]	]	PUNCT
admet-194	87	20	.	.	PUNCT
admet-194	88	1	2.1.1.1.3	2.1.1.1.3	NUM
admet-194	88	2	α	α	NOUN
admet-194	88	3	-	-	PUNCT
admet-194	88	4	secretase	secretase	ADJ
admet-194	88	5	activation	activation	NOUN
admet-194	88	6	since	since	SCONJ
admet-194	88	7	α	α	NOUN
admet-194	88	8	-	-	NOUN
admet-194	88	9	secretase	secretase	NOUN
admet-194	88	10	competes	compete	VERB
admet-194	88	11	for	for	ADP
admet-194	88	12	cleaving	cleave	VERB
admet-194	88	13	app	app	NOUN
admet-194	88	14	with	with	ADP
admet-194	88	15	β	β	NOUN
admet-194	88	16	-	-	NOUN
admet-194	88	17	secretase	secretase	NOUN
admet-194	88	18	,	,	PUNCT
admet-194	88	19	enhancement	enhancement	NOUN
admet-194	88	20	of	of	ADP
admet-194	88	21	α	α	NOUN
admet-194	88	22	-	-	PUNCT
admet-194	88	23	secretase	secretase	NOUN
admet-194	88	24	activity	activity	NOUN
admet-194	88	25	can	can	AUX
admet-194	88	26	upregulate	upregulate	VERB
admet-194	88	27	non	non	ADJ
admet-194	88	28	-	-	ADJ
admet-194	88	29	amyloidogenic	amyloidogenic	ADJ
admet-194	88	30	pathway	pathway	NOUN
admet-194	88	31	,	,	PUNCT
admet-194	88	32	which	which	PRON
admet-194	88	33	may	may	AUX
admet-194	88	34	decrease	decrease	VERB
admet-194	88	35	aβ	aβ	DET
admet-194	88	36	generation	generation	NOUN
admet-194	88	37	and	and	CCONJ
admet-194	88	38	have	have	VERB
admet-194	88	39	therapeutic	therapeutic	ADJ
admet-194	88	40	potential	potential	NOUN
admet-194	88	41	.	.	PUNCT
admet-194	89	1	a	a	DET
admet-194	89	2	phase	phase	NOUN
admet-194	89	3	2a	2a	NUM
admet-194	89	4	trial	trial	NOUN
admet-194	89	5	with	with	ADP
admet-194	89	6	etazolate	etazolate	ADJ
admet-194	89	7	(	(	PUNCT
admet-194	89	8	eht-0202	eht-0202	NOUN
admet-194	89	9	)	)	PUNCT
admet-194	89	10	has	have	AUX
admet-194	89	11	elaborated	elaborate	VERB
admet-194	89	12	that	that	SCONJ
admet-194	89	13	this	this	DET
admet-194	89	14	drug	drug	NOUN
admet-194	89	15	is	be	AUX
admet-194	89	16	safe	safe	ADJ
admet-194	89	17	for	for	ADP
admet-194	89	18	ad	ad	NOUN
admet-194	89	19	patients	patient	NOUN
admet-194	89	20	and	and	CCONJ
admet-194	89	21	well	well	ADV
admet-194	89	22	tolerated	tolerate	VERB
admet-194	89	23	,	,	PUNCT
admet-194	89	24	which	which	PRON
admet-194	89	25	offer	offer	VERB
admet-194	89	26	a	a	DET
admet-194	89	27	good	good	ADJ
admet-194	89	28	support	support	NOUN
admet-194	89	29	for	for	ADP
admet-194	89	30	further	further	ADJ
admet-194	89	31	studies	study	NOUN
admet-194	89	32	of	of	ADP
admet-194	89	33	this	this	DET
admet-194	89	34	compound	compound	NOUN
admet-194	90	1	[	[	X
admet-194	90	2	41	41	NUM
admet-194	90	3	]	]	PUNCT
admet-194	90	4	.	.	PUNCT
admet-194	91	1	bryostatin-1	bryostatin-1	NUM
admet-194	91	2	is	be	AUX
admet-194	91	3	another	another	DET
admet-194	91	4	compound	compound	NOUN
admet-194	91	5	which	which	PRON
admet-194	91	6	has	have	AUX
admet-194	91	7	entered	enter	VERB
admet-194	91	8	phase	phase	NOUN
admet-194	91	9	2	2	NUM
admet-194	91	10	trials	trial	NOUN
admet-194	91	11	to	to	PART
admet-194	91	12	evaluate	evaluate	VERB
admet-194	91	13	its	its	PRON
admet-194	91	14	safety	safety	NOUN
admet-194	91	15	,	,	PUNCT
admet-194	91	16	tolerability	tolerability	NOUN
admet-194	91	17	and	and	CCONJ
admet-194	91	18	potential	potential	ADJ
admet-194	91	19	effectiveness	effectiveness	NOUN
admet-194	91	20	,	,	PUNCT
admet-194	91	21	for	for	SCONJ
admet-194	91	22	it	it	PRON
admet-194	91	23	showed	show	VERB
admet-194	91	24	encouraging	encouraging	ADJ
admet-194	91	25	capacities	capacity	NOUN
admet-194	91	26	of	of	ADP
admet-194	91	27	inhibiting	inhibit	VERB
admet-194	91	28	aβ40	aβ40	PROPN
admet-194	91	29	and	and	CCONJ
admet-194	91	30	aβ42	aβ42	PROPN
admet-194	91	31	,	,	PUNCT
admet-194	91	32	and	and	CCONJ
admet-194	91	33	improving	improve	VERB
admet-194	91	34	behavioural	behavioural	ADJ
admet-194	91	35	assessment	assessment	NOUN
admet-194	91	36	in	in	ADP
admet-194	91	37	ad	ad	NOUN
admet-194	91	38	mouse	mouse	NOUN
admet-194	91	39	model	model	NOUN
admet-194	91	40	[	[	X
admet-194	91	41	42	42	NUM
admet-194	91	42	]	]	PUNCT
admet-194	91	43	.	.	PUNCT
admet-194	92	1	however	however	ADV
admet-194	92	2	,	,	PUNCT
admet-194	92	3	the	the	DET
admet-194	92	4	process	process	NOUN
admet-194	92	5	of	of	ADP
admet-194	92	6	this	this	DET
admet-194	92	7	compound	compound	NOUN
admet-194	92	8	in	in	ADP
admet-194	92	9	one	one	NUM
admet-194	92	10	phase	phase	NOUN
admet-194	92	11	2	2	NUM
admet-194	92	12	trial	trial	NOUN
admet-194	92	13	is	be	AUX
admet-194	92	14	uncovered	uncover	VERB
admet-194	92	15	[	[	X
admet-194	92	16	43	43	NUM
admet-194	92	17	]	]	PUNCT
admet-194	92	18	,	,	PUNCT
admet-194	92	19	and	and	CCONJ
admet-194	92	20	one	one	NUM
admet-194	92	21	was	be	AUX
admet-194	92	22	terminated	terminate	VERB
admet-194	92	23	[	[	X
admet-194	92	24	44	44	NUM
admet-194	92	25	]	]	PUNCT
admet-194	92	26	,	,	PUNCT
admet-194	92	27	and	and	CCONJ
admet-194	92	28	another	another	PRON
admet-194	92	29	is	be	AUX
admet-194	92	30	not	not	PART
admet-194	92	31	open	open	ADJ
admet-194	92	32	yet	yet	ADV
admet-194	92	33	for	for	ADP
admet-194	92	34	participant	participant	ADJ
admet-194	92	35	recruitment	recruitment	NOUN
admet-194	93	1	[	[	X
admet-194	93	2	45	45	NUM
admet-194	93	3	]	]	PUNCT
admet-194	93	4	.	.	PUNCT
admet-194	94	1	it	it	PRON
admet-194	94	2	remains	remain	VERB
admet-194	94	3	to	to	PART
admet-194	94	4	be	be	AUX
admet-194	94	5	seen	see	VERB
admet-194	94	6	if	if	SCONJ
admet-194	94	7	this	this	DET
admet-194	94	8	compound	compound	NOUN
admet-194	94	9	shows	show	VERB
admet-194	94	10	positive	positive	ADJ
admet-194	94	11	indications	indication	NOUN
admet-194	94	12	.	.	PUNCT
admet-194	95	1	another	another	DET
admet-194	95	2	compound	compound	NOUN
admet-194	95	3	,	,	PUNCT
admet-194	95	4	exebryl-1	exebryl-1	PRON
admet-194	95	5	,	,	PUNCT
admet-194	95	6	also	also	ADV
admet-194	95	7	showed	show	VERB
admet-194	95	8	positive	positive	ADJ
admet-194	95	9	results	result	NOUN
admet-194	95	10	with	with	ADP
admet-194	95	11	substantial	substantial	ADJ
admet-194	95	12	reduction	reduction	NOUN
admet-194	95	13	of	of	ADP
admet-194	95	14	aβ	aβ	DET
admet-194	95	15	formation	formation	NOUN
admet-194	95	16	and	and	CCONJ
admet-194	95	17	aggregation	aggregation	NOUN
admet-194	95	18	in	in	ADP
admet-194	95	19	ad	ad	NOUN
admet-194	95	20	transgenic	transgenic	NOUN
admet-194	95	21	mice	mouse	NOUN
admet-194	95	22	,	,	PUNCT
admet-194	95	23	it	it	PRON
admet-194	95	24	has	have	AUX
admet-194	95	25	been	be	AUX
admet-194	95	26	regarded	regard	VERB
admet-194	95	27	as	as	ADP
admet-194	95	28	another	another	DET
admet-194	95	29	promising	promising	ADJ
admet-194	95	30	candidate	candidate	NOUN
admet-194	95	31	to	to	PART
admet-194	95	32	cure	cure	VERB
admet-194	95	33	ad	ad	NOUN
admet-194	95	34	[	[	X
admet-194	95	35	46	46	NUM
admet-194	95	36	]	]	PUNCT
admet-194	95	37	.	.	PUNCT
admet-194	96	1	accordingly	accordingly	ADV
admet-194	96	2	,	,	PUNCT
admet-194	96	3	clinical	clinical	ADJ
admet-194	96	4	evaluation	evaluation	NOUN
admet-194	96	5	is	be	AUX
admet-194	96	6	expected	expect	VERB
admet-194	96	7	to	to	PART
admet-194	96	8	take	take	VERB
admet-194	96	9	place	place	NOUN
admet-194	96	10	in	in	ADP
admet-194	96	11	china	china	PROPN
admet-194	96	12	and	and	CCONJ
admet-194	96	13	us	we	PRON
admet-194	96	14	.	.	PUNCT
admet-194	97	1	2.1.1.2	2.1.1.2	NUM
admet-194	97	2	promotion	promotion	NOUN
admet-194	97	3	of	of	ADP
admet-194	97	4	aβ	aβ	NOUN
admet-194	97	5	clearance	clearance	NOUN
admet-194	97	6	2.1.1.2.1	2.1.1.2.1	NUM
admet-194	97	7	immunotherapy	immunotherapy	NOUN
admet-194	97	8	active	active	ADJ
admet-194	97	9	(	(	PUNCT
admet-194	97	10	vaccination	vaccination	NOUN
admet-194	97	11	)	)	PUNCT
admet-194	97	12	and	and	CCONJ
admet-194	97	13	passive	passive	ADJ
admet-194	97	14	(	(	PUNCT
admet-194	97	15	monoclonal	monoclonal	NOUN
admet-194	97	16	antibodies	antibody	NOUN
admet-194	97	17	)	)	PUNCT
admet-194	97	18	immunizations	immunization	NOUN
admet-194	97	19	have	have	AUX
admet-194	97	20	been	be	AUX
admet-194	97	21	focused	focus	VERB
admet-194	97	22	on	on	ADP
admet-194	97	23	to	to	PART
admet-194	97	24	remove	remove	VERB
admet-194	97	25	soluble	soluble	ADJ
admet-194	97	26	and	and	CCONJ
admet-194	97	27	aggregated	aggregate	VERB
admet-194	97	28	aβ	aβ	NOUN
admet-194	97	29	for	for	ADP
admet-194	97	30	their	their	PRON
admet-194	97	31	promising	promising	ADJ
admet-194	97	32	data	datum	NOUN
admet-194	97	33	from	from	ADP
admet-194	97	34	in	in	ADP
admet-194	97	35	vitro	vitro	X
admet-194	97	36	researches	research	NOUN
admet-194	97	37	and	and	CCONJ
admet-194	97	38	animal	animal	NOUN
admet-194	97	39	studies	study	NOUN
admet-194	97	40	.	.	PUNCT
admet-194	98	1	one	one	NUM
admet-194	98	2	of	of	ADP
admet-194	98	3	the	the	DET
admet-194	98	4	premier	premier	ADJ
admet-194	98	5	active	active	ADJ
admet-194	98	6	immunization	immunization	NOUN
admet-194	98	7	trials	trial	NOUN
admet-194	98	8	was	be	AUX
admet-194	98	9	conducted	conduct	VERB
admet-194	98	10	using	use	VERB
admet-194	98	11	human	human	ADJ
admet-194	98	12	aβ42	aβ42	PROPN
admet-194	98	13	(	(	PUNCT
admet-194	98	14	an-1792	an-1792	NOUN
admet-194	98	15	)	)	PUNCT
admet-194	98	16	and	and	CCONJ
admet-194	98	17	a	a	DET
admet-194	98	18	thelper	thelper	NOUN
admet-194	98	19	adjuvant	adjuvant	ADJ
admet-194	98	20	(	(	PUNCT
admet-194	98	21	qs-21	qs-21	NUM
admet-194	98	22	)	)	PUNCT
admet-194	98	23	in	in	ADP
admet-194	98	24	combination	combination	NOUN
admet-194	98	25	.	.	PUNCT
admet-194	99	1	however	however	ADV
admet-194	99	2	,	,	PUNCT
admet-194	99	3	the	the	DET
admet-194	99	4	phase	phase	NOUN
admet-194	99	5	2	2	NUM
admet-194	99	6	study	study	NOUN
admet-194	99	7	was	be	AUX
admet-194	99	8	terminated	terminate	VERB
admet-194	99	9	because	because	SCONJ
admet-194	99	10	of	of	ADP
admet-194	99	11	severe	severe	ADJ
admet-194	99	12	side	side	NOUN
admet-194	99	13	effect	effect	NOUN
admet-194	99	14	,	,	PUNCT
admet-194	99	15	meningoencephalitis	meningoencephalitis	NOUN
admet-194	99	16	,	,	PUNCT
admet-194	99	17	and	and	CCONJ
admet-194	99	18	low	low	ADJ
admet-194	99	19	probability	probability	NOUN
admet-194	99	20	of	of	ADP
admet-194	99	21	predetermined	predetermined	ADJ
admet-194	99	22	antibody	antibody	NOUN
admet-194	99	23	response	response	NOUN
admet-194	99	24	[	[	X
admet-194	99	25	47	47	NUM
admet-194	99	26	]	]	PUNCT
admet-194	99	27	.	.	PUNCT
admet-194	100	1	the	the	DET
admet-194	100	2	development	development	NOUN
admet-194	100	3	of	of	ADP
admet-194	100	4	new	new	ADJ
admet-194	100	5	vaccines	vaccine	NOUN
admet-194	100	6	without	without	ADP
admet-194	100	7	the	the	DET
admet-194	100	8	amino	amino	NOUN
admet-194	100	9	acid	acid	NOUN
admet-194	100	10	parts	part	NOUN
admet-194	100	11	that	that	PRON
admet-194	100	12	stimulating	stimulate	VERB
admet-194	100	13	t	t	NOUN
admet-194	100	14	cells	cell	NOUN
admet-194	100	15	has	have	AUX
admet-194	100	16	been	be	AUX
admet-194	100	17	considered	consider	VERB
admet-194	100	18	to	to	PART
admet-194	100	19	avoid	avoid	VERB
admet-194	100	20	neuroinflammation	neuroinflammation	NOUN
admet-194	100	21	and	and	CCONJ
admet-194	100	22	toxicity	toxicity	NOUN
admet-194	100	23	.	.	PUNCT
admet-194	101	1	as	as	SCONJ
admet-194	101	2	cad-106	cad-106	NOUN
admet-194	101	3	has	have	AUX
admet-194	101	4	shown	show	VERB
admet-194	101	5	a	a	DET
admet-194	101	6	good	good	ADJ
admet-194	101	7	safety	safety	NOUN
admet-194	101	8	profile	profile	NOUN
admet-194	101	9	and	and	CCONJ
admet-194	101	10	acceptable	acceptable	ADJ
admet-194	101	11	antibody	antibody	NOUN
admet-194	101	12	response	response	NOUN
admet-194	101	13	in	in	ADP
admet-194	101	14	a	a	DET
admet-194	101	15	phase	phase	NOUN
admet-194	101	16	1	1	NUM
admet-194	101	17	trial	trial	NOUN
admet-194	101	18	[	[	X
admet-194	101	19	48	48	NUM
admet-194	101	20	]	]	PUNCT
admet-194	101	21	,	,	PUNCT
admet-194	101	22	it	it	PRON
admet-194	101	23	is	be	AUX
admet-194	101	24	now	now	ADV
admet-194	101	25	being	be	AUX
admet-194	101	26	tested	test	VERB
admet-194	101	27	in	in	ADP
admet-194	101	28	phase	phase	NOUN
admet-194	101	29	2	2	NUM
admet-194	101	30	trials	trial	NOUN
admet-194	101	31	.	.	PUNCT
admet-194	102	1	acc-001	acc-001	NOUN
admet-194	102	2	and	and	CCONJ
admet-194	102	3	v950	v950	PROPN
admet-194	102	4	are	be	AUX
admet-194	102	5	conjugate	conjugate	ADJ
admet-194	102	6	of	of	ADP
admet-194	102	7	multiple	multiple	ADJ
admet-194	102	8	short	short	ADJ
admet-194	102	9	aβ	aβ	NOUN
admet-194	102	10	fragments	fragment	NOUN
admet-194	102	11	,	,	PUNCT
admet-194	102	12	which	which	PRON
admet-194	102	13	can	can	AUX
admet-194	102	14	cause	cause	VERB
admet-194	102	15	an	an	DET
admet-194	102	16	immune	immune	ADJ
admet-194	102	17	response	response	NOUN
admet-194	102	18	based	base	VERB
admet-194	102	19	on	on	ADP
admet-194	102	20	the	the	DET
admet-194	102	21	bcell	bcell	PROPN
admet-194	102	22	epitope	epitope	PROPN
admet-194	102	23	that	that	PRON
admet-194	102	24	is	be	AUX
admet-194	102	25	included	include	VERB
admet-194	102	26	in	in	ADP
admet-194	102	27	the	the	DET
admet-194	102	28	n	n	CCONJ
admet-194	102	29	-	-	PUNCT
admet-194	102	30	terminal	terminal	ADJ
admet-194	102	31	aβ	aβ	PRON
admet-194	102	32	fragment	fragment	NOUN
admet-194	103	1	[	[	X
admet-194	103	2	13	13	NUM
admet-194	103	3	]	]	PUNCT
admet-194	103	4	.	.	PUNCT
admet-194	104	1	v950	v950	PROPN
admet-194	104	2	was	be	AUX
admet-194	104	3	tested	test	VERB
admet-194	104	4	in	in	ADP
admet-194	104	5	a	a	DET
admet-194	104	6	phase	phase	NOUN
admet-194	104	7	1	1	NUM
admet-194	104	8	trial	trial	NOUN
admet-194	104	9	as	as	ADP
admet-194	104	10	an	an	DET
admet-194	104	11	aluminium	aluminium	NOUN
admet-194	104	12	-	-	PUNCT
admet-194	104	13	containing	contain	VERB
admet-194	104	14	adjuvant	adjuvant	NOUN
admet-194	104	15	[	[	X
admet-194	104	16	49	49	NUM
admet-194	104	17	]	]	PUNCT
admet-194	104	18	,	,	PUNCT
admet-194	104	19	which	which	PRON
admet-194	104	20	was	be	AUX
admet-194	104	21	completed	complete	VERB
admet-194	104	22	in	in	ADP
admet-194	104	23	2012	2012	NUM
admet-194	104	24	.	.	PUNCT
admet-194	105	1	acc-001	acc-001	PROPN
admet-194	105	2	was	be	AUX
admet-194	105	3	being	be	AUX
admet-194	105	4	tested	test	VERB
admet-194	105	5	in	in	ADP
admet-194	105	6	multiple	multiple	ADJ
admet-194	105	7	phase	phase	NOUN
admet-194	105	8	2	2	NUM
admet-194	105	9	trials	trial	NOUN
admet-194	105	10	,	,	PUNCT
admet-194	105	11	with	with	ADP
admet-194	105	12	or	or	CCONJ
admet-194	105	13	without	without	ADP
admet-194	105	14	qs-21	qs-21	NOUN
admet-194	105	15	.	.	PUNCT
admet-194	106	1	however	however	ADV
admet-194	106	2	,	,	PUNCT
admet-194	106	3	acc-001	acc-001	PROPN
admet-194	106	4	has	have	AUX
admet-194	106	5	been	be	AUX
admet-194	106	6	discontinued	discontinue	VERB
admet-194	106	7	from	from	ADP
admet-194	106	8	development	development	NOUN
admet-194	106	9	since	since	SCONJ
admet-194	106	10	may	may	PROPN
admet-194	106	11	9	9	NUM
admet-194	106	12	,	,	PUNCT
admet-194	106	13	2013	2013	NUM
admet-194	106	14	[	[	X
admet-194	106	15	50	50	NUM
admet-194	106	16	]	]	PUNCT
admet-194	106	17	.	.	PUNCT
admet-194	107	1	a	a	DET
admet-194	107	2	phase	phase	NOUN
admet-194	107	3	1/2	1/2	NUM
admet-194	107	4	trial	trial	NOUN
admet-194	107	5	of	of	ADP
admet-194	107	6	aci-24	aci-24	ADJ
admet-194	107	7	began	begin	VERB
admet-194	107	8	in	in	ADP
admet-194	107	9	the	the	DET
admet-194	107	10	year	year	NOUN
admet-194	107	11	of	of	ADP
admet-194	107	12	2009	2009	NUM
admet-194	107	13	,	,	PUNCT
admet-194	107	14	to	to	PART
admet-194	107	15	explore	explore	VERB
admet-194	107	16	the	the	DET
admet-194	107	17	safety	safety	NOUN
admet-194	107	18	,	,	PUNCT
admet-194	107	19	efficacy	efficacy	NOUN
admet-194	107	20	,	,	PUNCT
admet-194	107	21	and	and	CCONJ
admet-194	107	22	immunogenicity	immunogenicity	NOUN
admet-194	107	23	of	of	ADP
admet-194	107	24	this	this	DET
admet-194	107	25	liposome	liposome	NOUN
admet-194	107	26	vaccine	vaccine	NOUN
admet-194	107	27	,	,	PUNCT
admet-194	107	28	which	which	PRON
admet-194	107	29	showed	show	VERB
admet-194	107	30	positive	positive	ADJ
admet-194	107	31	consequence	consequence	NOUN
admet-194	107	32	in	in	ADP
admet-194	107	33	ad	ad	NOUN
admet-194	107	34	transgenic	transgenic	NOUN
admet-194	107	35	mice	mouse	NOUN
admet-194	107	36	[	[	X
admet-194	107	37	51	51	NUM
admet-194	107	38	]	]	PUNCT
admet-194	107	39	.	.	PUNCT
admet-194	108	1	another	another	DET
admet-194	108	2	compound	compound	NOUN
admet-194	108	3	ub311	ub311	NOUN
admet-194	108	4	was	be	AUX
admet-194	108	5	undergone	undergo	VERB
admet-194	108	6	a	a	DET
admet-194	108	7	phase	phase	NOUN
admet-194	108	8	1	1	NUM
admet-194	108	9	study	study	NOUN
admet-194	108	10	in	in	ADP
admet-194	108	11	taiwan	taiwan	PROPN
admet-194	108	12	to	to	PART
admet-194	108	13	address	address	VERB
admet-194	108	14	the	the	DET
admet-194	108	15	safety	safety	NOUN
admet-194	108	16	,	,	PUNCT
admet-194	108	17	tolerability	tolerability	NOUN
admet-194	108	18	and	and	CCONJ
admet-194	108	19	immunogenicity	immunogenicity	NOUN
admet-194	108	20	issues	issue	NOUN
admet-194	108	21	with	with	ADP
admet-194	108	22	favourable	favourable	ADJ
admet-194	108	23	results	result	NOUN
admet-194	108	24	obtained	obtain	VERB
admet-194	108	25	,	,	PUNCT
admet-194	108	26	including	include	VERB
admet-194	108	27	positive	positive	ADJ
admet-194	108	28	antibody	antibody	NOUN
admet-194	108	29	responses	response	NOUN
admet-194	108	30	and	and	CCONJ
admet-194	108	31	elevated	elevated	ADJ
admet-194	108	32	neuropsychological	neuropsychological	ADJ
admet-194	108	33	outcomes	outcome	NOUN
admet-194	108	34	without	without	ADP
admet-194	108	35	any	any	DET
admet-194	108	36	serious	serious	ADJ
admet-194	108	37	side	side	NOUN
admet-194	108	38	effects	effect	NOUN
admet-194	108	39	[	[	X
admet-194	108	40	52	52	NUM
admet-194	108	41	]	]	PUNCT
admet-194	108	42	.	.	PUNCT
admet-194	109	1	the	the	DET
admet-194	109	2	other	other	ADJ
admet-194	109	3	phase	phase	NOUN
admet-194	109	4	1	1	NUM
admet-194	109	5	trial	trial	NOUN
admet-194	109	6	held	hold	VERB
admet-194	109	7	by	by	ADP
admet-194	109	8	the	the	DET
admet-194	109	9	same	same	ADJ
admet-194	109	10	group	group	NOUN
admet-194	109	11	to	to	PART
admet-194	109	12	monitor	monitor	VERB
admet-194	109	13	long	long	ADJ
admet-194	109	14	-	-	PUNCT
admet-194	109	15	term	term	NOUN
admet-194	109	16	efficacy	efficacy	NOUN
admet-194	109	17	and	and	CCONJ
admet-194	109	18	immunogenicity	immunogenicity	NOUN
admet-194	109	19	of	of	ADP
admet-194	109	20	the	the	DET
admet-194	109	21	same	same	ADJ
admet-194	109	22	vaccine	vaccine	NOUN
admet-194	109	23	was	be	AUX
admet-194	109	24	completed	complete	VERB
admet-194	109	25	in	in	ADP
admet-194	109	26	the	the	DET
admet-194	109	27	year	year	NOUN
admet-194	109	28	of	of	ADP
admet-194	109	29	2011	2011	NUM
admet-194	109	30	but	but	CCONJ
admet-194	109	31	no	no	DET
admet-194	109	32	result	result	NOUN
admet-194	109	33	has	have	AUX
admet-194	109	34	reported	report	VERB
admet-194	109	35	[	[	X
admet-194	109	36	53	53	NUM
admet-194	109	37	]	]	PUNCT
admet-194	109	38	.	.	PUNCT
admet-194	110	1	a	a	DET
admet-194	110	2	phase	phase	NOUN
admet-194	110	3	2	2	NUM
admet-194	110	4	trial	trial	NOUN
admet-194	110	5	of	of	ADP
admet-194	110	6	ub311	ub311	NOUN
admet-194	110	7	was	be	AUX
admet-194	110	8	reported	report	VERB
admet-194	110	9	being	be	AUX
admet-194	110	10	initiated	initiate	VERB
admet-194	110	11	by	by	ADP
admet-194	110	12	admet	admet	PROPN
admet-194	110	13	&	&	CCONJ
admet-194	110	14	dmpk	dmpk	PROPN
admet-194	110	15	3(3	3(3	NUM
admet-194	110	16	)	)	PUNCT
admet-194	110	17	(	(	PUNCT
admet-194	110	18	2015	2015	NUM
admet-194	110	19	)	)	PUNCT
admet-194	110	20	216	216	NUM
admet-194	110	21	-	-	SYM
admet-194	110	22	234	234	NUM
admet-194	110	23	chemical	chemical	NOUN
admet-194	110	24	and	and	CCONJ
admet-194	110	25	physical	physical	ADJ
admet-194	110	26	approaches	approach	NOUN
admet-194	110	27	for	for	ADP
admet-194	110	28	the	the	DET
admet-194	110	29	treatment	treatment	NOUN
admet-194	110	30	of	of	ADP
admet-194	110	31	ad	ad	NOUN
admet-194	110	32	doi	doi	NOUN
admet-194	110	33	:	:	PUNCT
admet-194	110	34	10.5599	10.5599	NUM
admet-194	110	35	/	/	SYM
admet-194	110	36	admet.3.3.194	admet.3.3.194	PROPN
admet-194	110	37	221	221	NUM
admet-194	110	38	united	united	ADJ
admet-194	110	39	biochemical	biochemical	PROPN
admet-194	110	40	,	,	PUNCT
admet-194	110	41	inc	inc	PROPN
admet-194	110	42	.	.	PROPN
admet-194	110	43	recently	recently	ADV
admet-194	111	1	[	[	X
admet-194	111	2	54	54	NUM
admet-194	111	3	]	]	PUNCT
admet-194	111	4	.	.	PUNCT
admet-194	112	1	some	some	DET
admet-194	112	2	severe	severe	ADJ
admet-194	112	3	side	side	NOUN
admet-194	112	4	effects	effect	NOUN
admet-194	112	5	induced	induce	VERB
admet-194	112	6	by	by	ADP
admet-194	112	7	vaccination	vaccination	NOUN
admet-194	112	8	and	and	CCONJ
admet-194	112	9	passive	passive	ADJ
admet-194	112	10	immunotherapy	immunotherapy	NOUN
admet-194	112	11	have	have	AUX
admet-194	112	12	been	be	AUX
admet-194	112	13	considered	consider	VERB
admet-194	112	14	an	an	DET
admet-194	112	15	alternative	alternative	ADJ
admet-194	112	16	immunotherapeutic	immunotherapeutic	ADJ
admet-194	112	17	strategy	strategy	NOUN
admet-194	112	18	,	,	PUNCT
admet-194	112	19	which	which	PRON
admet-194	112	20	are	be	AUX
admet-194	112	21	based	base	VERB
admet-194	112	22	on	on	ADP
admet-194	112	23	monoclonal	monoclonal	NOUN
admet-194	112	24	antibodies	antibody	NOUN
admet-194	112	25	or	or	CCONJ
admet-194	112	26	polyclonal	polyclonal	ADJ
admet-194	112	27	immunoglobulins	immunoglobulin	NOUN
admet-194	112	28	to	to	PART
admet-194	112	29	promote	promote	VERB
admet-194	112	30	the	the	DET
admet-194	112	31	clearance	clearance	NOUN
admet-194	112	32	of	of	ADP
admet-194	112	33	aβ	aβ	NOUN
admet-194	112	34	.	.	PUNCT
admet-194	113	1	however	however	ADV
admet-194	113	2	,	,	PUNCT
admet-194	113	3	revascularization	revascularization	NOUN
admet-194	113	4	would	would	AUX
admet-194	113	5	be	be	AUX
admet-194	113	6	a	a	DET
admet-194	113	7	potential	potential	ADJ
admet-194	113	8	issue	issue	NOUN
admet-194	113	9	for	for	ADP
admet-194	113	10	long	long	ADJ
admet-194	113	11	term	term	NOUN
admet-194	113	12	treatment	treatment	NOUN
admet-194	113	13	of	of	ADP
admet-194	113	14	passive	passive	ADJ
admet-194	113	15	immunization	immunization	NOUN
admet-194	113	16	,	,	PUNCT
admet-194	113	17	for	for	SCONJ
admet-194	113	18	these	these	DET
admet-194	113	19	therapies	therapy	NOUN
admet-194	113	20	could	could	AUX
admet-194	113	21	lead	lead	VERB
admet-194	113	22	to	to	ADP
admet-194	113	23	cerebral	cerebral	ADJ
admet-194	113	24	microhemorrhages	microhemorrhage	NOUN
admet-194	113	25	related	relate	VERB
admet-194	113	26	to	to	ADP
admet-194	113	27	vascular	vascular	ADJ
admet-194	113	28	amyloid	amyloid	NOUN
admet-194	113	29	deposits	deposit	NOUN
admet-194	113	30	[	[	X
admet-194	113	31	55	55	NUM
admet-194	113	32	]	]	PUNCT
admet-194	113	33	.	.	PUNCT
admet-194	114	1	nevertheless	nevertheless	ADV
admet-194	114	2	,	,	PUNCT
admet-194	114	3	some	some	DET
admet-194	114	4	monoclonal	monoclonal	NOUN
admet-194	114	5	antibodies	antibody	NOUN
admet-194	114	6	have	have	AUX
admet-194	114	7	already	already	ADV
admet-194	114	8	been	be	AUX
admet-194	114	9	tested	test	VERB
admet-194	114	10	in	in	ADP
admet-194	114	11	ad	ad	NOUN
admet-194	114	12	patients	patient	NOUN
admet-194	114	13	,	,	PUNCT
admet-194	114	14	like	like	ADP
admet-194	114	15	solanezumab	solanezumab	NOUN
admet-194	114	16	(	(	PUNCT
admet-194	114	17	ly-2062430	ly-2062430	NOUN
admet-194	114	18	)	)	PUNCT
admet-194	114	19	,	,	PUNCT
admet-194	114	20	bapineuzumab	bapineuzumab	X
admet-194	114	21	(	(	PUNCT
admet-194	114	22	aab-001	aab-001	PROPN
admet-194	114	23	)	)	PUNCT
admet-194	114	24	,	,	PUNCT
admet-194	114	25	and	and	CCONJ
admet-194	114	26	gantenerumab	gantenerumab	NOUN
admet-194	114	27	(	(	PUNCT
admet-194	114	28	rg1450	rg1450	ADV
admet-194	114	29	)	)	PUNCT
admet-194	114	30	,	,	PUNCT
admet-194	114	31	ponezumab	ponezumab	NOUN
admet-194	114	32	(	(	PUNCT
admet-194	114	33	pf-04360365	pf-04360365	PROPN
admet-194	114	34	)	)	PUNCT
admet-194	114	35	,	,	PUNCT
admet-194	114	36	gsk-933776	gsk-933776	NOUN
admet-194	114	37	,	,	PUNCT
admet-194	114	38	mabt-5102a	mabt-5102a	NOUN
admet-194	114	39	and	and	CCONJ
admet-194	114	40	immunoglobulins	immunoglobulin	NOUN
admet-194	114	41	(	(	PUNCT
admet-194	114	42	ivig	ivig	NOUN
admet-194	114	43	)	)	PUNCT
admet-194	115	1	[	[	X
admet-194	115	2	13	13	NUM
admet-194	115	3	]	]	PUNCT
admet-194	115	4	.	.	PUNCT
admet-194	116	1	serious	serious	ADJ
admet-194	116	2	adverse	adverse	ADJ
admet-194	116	3	effect	effect	NOUN
admet-194	116	4	,	,	PUNCT
admet-194	116	5	vasogenicedema	vasogenicedema	NOUN
admet-194	116	6	,	,	PUNCT
admet-194	116	7	occurred	occur	VERB
admet-194	116	8	in	in	ADP
admet-194	116	9	the	the	DET
admet-194	116	10	phase	phase	NOUN
admet-194	116	11	2	2	NUM
admet-194	116	12	trial	trial	NOUN
admet-194	116	13	of	of	ADP
admet-194	116	14	bapineuzumab	bapineuzumab	NOUN
admet-194	116	15	,	,	PUNCT
admet-194	116	16	with	with	ADP
admet-194	116	17	no	no	DET
admet-194	116	18	significant	significant	ADJ
admet-194	116	19	improvements	improvement	NOUN
admet-194	116	20	of	of	ADP
admet-194	116	21	cognition	cognition	NOUN
admet-194	116	22	and	and	CCONJ
admet-194	116	23	daily	daily	ADJ
admet-194	116	24	activities	activity	NOUN
admet-194	116	25	[	[	X
admet-194	116	26	56	56	NUM
admet-194	116	27	]	]	PUNCT
admet-194	116	28	.	.	PUNCT
admet-194	117	1	non	non	ADJ
admet-194	117	2	-	-	ADJ
admet-194	117	3	significant	significant	ADJ
admet-194	117	4	efficacy	efficacy	NOUN
admet-194	117	5	and	and	CCONJ
admet-194	117	6	cognitive	cognitive	ADJ
admet-194	117	7	enhancement	enhancement	NOUN
admet-194	117	8	were	be	AUX
admet-194	117	9	found	find	VERB
admet-194	117	10	in	in	ADP
admet-194	117	11	apoe	apoe	PROPN
admet-194	117	12	ε4	ε4	PROPN
admet-194	117	13	non	non	ADJ
admet-194	117	14	-	-	NOUN
admet-194	117	15	carriers	carrier	NOUN
admet-194	117	16	,	,	PUNCT
admet-194	117	17	so	so	ADV
admet-194	117	18	two	two	NUM
admet-194	117	19	phase	phase	NOUN
admet-194	117	20	3	3	NUM
admet-194	117	21	trials	trial	NOUN
admet-194	117	22	of	of	ADP
admet-194	117	23	this	this	DET
admet-194	117	24	humanized	humanize	VERB
admet-194	117	25	monoclonal	monoclonal	NOUN
admet-194	117	26	antibody	antibody	NOUN
admet-194	117	27	were	be	AUX
admet-194	117	28	initiated	initiate	VERB
admet-194	117	29	using	use	VERB
admet-194	117	30	apoe	apoe	ADJ
admet-194	117	31	ε4	ε4	NOUN
admet-194	117	32	carriers	carrier	NOUN
admet-194	117	33	and	and	CCONJ
admet-194	117	34	non	non	NOUN
admet-194	117	35	-	-	NOUN
admet-194	117	36	carriers	carrier	NOUN
admet-194	117	37	respectively	respectively	ADV
admet-194	117	38	in	in	ADP
admet-194	117	39	mild	mild	ADJ
admet-194	117	40	-	-	PUNCT
admet-194	117	41	to	to	ADP
admet-194	117	42	-	-	PUNCT
admet-194	117	43	moderate	moderate	ADJ
admet-194	117	44	ad	ad	NOUN
admet-194	117	45	patients	patient	NOUN
admet-194	117	46	.	.	PUNCT
admet-194	118	1	unfortunately	unfortunately	ADV
admet-194	118	2	,	,	PUNCT
admet-194	118	3	the	the	DET
admet-194	118	4	consequences	consequence	NOUN
admet-194	118	5	were	be	AUX
admet-194	118	6	disillusionary	disillusionary	ADJ
admet-194	118	7	and	and	CCONJ
admet-194	118	8	bapineuzumab	bapineuzumab	NOUN
admet-194	118	9	did	do	AUX
admet-194	118	10	not	not	PART
admet-194	118	11	improve	improve	VERB
admet-194	118	12	clinical	clinical	ADJ
admet-194	118	13	outcomes	outcome	NOUN
admet-194	118	14	in	in	ADP
admet-194	118	15	ad	ad	NOUN
admet-194	118	16	patients	patient	NOUN
admet-194	118	17	[	[	X
admet-194	118	18	57	57	NUM
admet-194	118	19	]	]	PUNCT
admet-194	118	20	.	.	PUNCT
admet-194	119	1	the	the	DET
admet-194	119	2	results	result	NOUN
admet-194	119	3	of	of	ADP
admet-194	119	4	phase	phase	NOUN
admet-194	119	5	1	1	NUM
admet-194	119	6	and	and	CCONJ
admet-194	119	7	2	2	NUM
admet-194	119	8	trials	trial	NOUN
admet-194	119	9	showed	show	VERB
admet-194	119	10	that	that	SCONJ
admet-194	119	11	solanezumab	solanezumab	NOUN
admet-194	119	12	might	might	AUX
admet-194	119	13	have	have	VERB
admet-194	119	14	pharmacological	pharmacological	ADJ
admet-194	119	15	function	function	NOUN
admet-194	119	16	in	in	ADP
admet-194	119	17	ad	ad	NOUN
admet-194	119	18	[	[	X
admet-194	119	19	58	58	NUM
admet-194	119	20	,	,	PUNCT
admet-194	119	21	59	59	NUM
admet-194	119	22	]	]	PUNCT
admet-194	119	23	,	,	PUNCT
admet-194	119	24	and	and	CCONJ
admet-194	119	25	two	two	NUM
admet-194	119	26	phase	phase	NOUN
admet-194	119	27	3	3	NUM
admet-194	119	28	trials	trial	NOUN
admet-194	119	29	were	be	AUX
admet-194	119	30	held	hold	VERB
admet-194	119	31	to	to	PART
admet-194	119	32	further	far	ADV
admet-194	119	33	explore	explore	VERB
admet-194	119	34	the	the	DET
admet-194	119	35	efficacy	efficacy	NOUN
admet-194	119	36	of	of	ADP
admet-194	119	37	this	this	DET
admet-194	119	38	humanized	humanize	VERB
admet-194	119	39	monoclonal	monoclonal	NOUN
admet-194	119	40	antibody	antibody	NOUN
admet-194	119	41	.	.	PUNCT
admet-194	120	1	however	however	ADV
admet-194	120	2	,	,	PUNCT
admet-194	120	3	the	the	DET
admet-194	120	4	disappointing	disappointing	ADJ
admet-194	120	5	results	result	NOUN
admet-194	120	6	showed	show	VERB
admet-194	120	7	that	that	SCONJ
admet-194	120	8	it	it	PRON
admet-194	120	9	failed	fail	VERB
admet-194	120	10	to	to	PART
admet-194	120	11	provide	provide	VERB
admet-194	120	12	improvement	improvement	NOUN
admet-194	120	13	of	of	ADP
admet-194	120	14	cognition	cognition	NOUN
admet-194	120	15	and	and	CCONJ
admet-194	120	16	functional	functional	ADJ
admet-194	120	17	ability	ability	NOUN
admet-194	120	18	[	[	X
admet-194	120	19	60	60	NUM
admet-194	120	20	]	]	PUNCT
admet-194	120	21	.	.	PUNCT
admet-194	121	1	as	as	ADP
admet-194	121	2	a	a	DET
admet-194	121	3	fully	fully	ADV
admet-194	121	4	human	human	ADJ
admet-194	121	5	anti	anti	ADJ
admet-194	121	6	-	-	ADJ
admet-194	121	7	aβ	aβ	ADJ
admet-194	121	8	antibody	antibody	NOUN
admet-194	121	9	,	,	PUNCT
admet-194	121	10	gantenerumab	gantenerumab	NOUN
admet-194	121	11	could	could	AUX
admet-194	121	12	reduce	reduce	VERB
admet-194	121	13	small	small	ADJ
admet-194	121	14	plaques	plaque	NOUN
admet-194	121	15	by	by	ADP
admet-194	121	16	recruiting	recruit	VERB
admet-194	121	17	microglia	microglia	NOUN
admet-194	121	18	,	,	PUNCT
admet-194	121	19	and	and	CCONJ
admet-194	121	20	prevents	prevent	VERB
admet-194	121	21	new	new	ADJ
admet-194	121	22	plaque	plaque	NOUN
admet-194	121	23	formation	formation	NOUN
admet-194	122	1	[	[	X
admet-194	122	2	61	61	NUM
admet-194	122	3	]	]	PUNCT
admet-194	122	4	.	.	PUNCT
admet-194	123	1	a	a	DET
admet-194	123	2	phase	phase	NOUN
admet-194	123	3	3	3	NUM
admet-194	123	4	trial	trial	NOUN
admet-194	123	5	of	of	ADP
admet-194	123	6	gantenerumab	gantenerumab	NOUN
admet-194	123	7	in	in	ADP
admet-194	123	8	1,000	1,000	NUM
admet-194	123	9	mild	mild	ADJ
admet-194	123	10	ad	ad	NOUN
admet-194	123	11	patients	patient	NOUN
admet-194	123	12	was	be	AUX
admet-194	123	13	initiated	initiate	VERB
admet-194	123	14	in	in	ADP
admet-194	123	15	the	the	DET
admet-194	123	16	year	year	NOUN
admet-194	123	17	of	of	ADP
admet-194	123	18	2014	2014	NUM
admet-194	123	19	[	[	X
admet-194	123	20	62	62	NUM
admet-194	123	21	]	]	PUNCT
admet-194	123	22	.	.	PUNCT
admet-194	124	1	ponezumab	ponezumab	NOUN
admet-194	124	2	is	be	AUX
admet-194	124	3	a	a	DET
admet-194	124	4	humanized	humanize	VERB
admet-194	124	5	igg2δa	igg2δa	PROPN
admet-194	124	6	monoclonal	monoclonal	NOUN
admet-194	124	7	antibody	antibody	NOUN
admet-194	124	8	which	which	PRON
admet-194	124	9	can	can	AUX
admet-194	124	10	bind	bind	VERB
admet-194	124	11	to	to	ADP
admet-194	124	12	aβ40	aβ40	PROPN
admet-194	124	13	.	.	PUNCT
admet-194	125	1	phase	phase	NOUN
admet-194	125	2	1	1	NUM
admet-194	125	3	trial	trial	NOUN
admet-194	125	4	manifested	manifest	VERB
admet-194	125	5	its	its	PRON
admet-194	125	6	good	good	ADJ
admet-194	125	7	tolerability	tolerability	NOUN
admet-194	125	8	in	in	ADP
admet-194	125	9	patients	patient	NOUN
admet-194	125	10	with	with	ADP
admet-194	125	11	mild	mild	ADJ
admet-194	125	12	-	-	PUNCT
admet-194	125	13	to	to	ADP
admet-194	125	14	-	-	PUNCT
admet-194	125	15	moderate	moderate	ADJ
admet-194	125	16	ad	ad	NOUN
admet-194	125	17	[	[	X
admet-194	125	18	63	63	NUM
admet-194	125	19	]	]	PUNCT
admet-194	125	20	,	,	PUNCT
admet-194	125	21	but	but	CCONJ
admet-194	125	22	two	two	NUM
admet-194	125	23	phase	phase	NOUN
admet-194	125	24	2	2	NUM
admet-194	125	25	trials	trial	NOUN
admet-194	125	26	showed	show	VERB
admet-194	125	27	no	no	DET
admet-194	125	28	effect	effect	NOUN
admet-194	125	29	on	on	ADP
admet-194	125	30	the	the	DET
admet-194	125	31	primary	primary	ADJ
admet-194	125	32	endpoints	endpoint	NOUN
admet-194	125	33	of	of	ADP
admet-194	125	34	change	change	NOUN
admet-194	125	35	in	in	ADP
admet-194	125	36	brain	brain	NOUN
admet-194	125	37	or	or	CCONJ
admet-194	125	38	cerebrospinal	cerebrospinal	ADJ
admet-194	125	39	fluid	fluid	NOUN
admet-194	125	40	(	(	PUNCT
admet-194	125	41	csf	csf	NOUN
admet-194	125	42	)	)	PUNCT
admet-194	125	43	aβ	aβ	NOUN
admet-194	125	44	burden	burden	NOUN
admet-194	126	1	[	[	X
admet-194	126	2	64	64	NUM
admet-194	126	3	]	]	PUNCT
admet-194	126	4	.	.	PUNCT
admet-194	127	1	the	the	DET
admet-194	127	2	safety	safety	NOUN
admet-194	127	3	and	and	CCONJ
admet-194	127	4	tolerability	tolerability	NOUN
admet-194	127	5	,	,	PUNCT
admet-194	127	6	as	as	ADV
admet-194	127	7	well	well	ADV
admet-194	127	8	as	as	ADP
admet-194	127	9	pharmacokinetics	pharmacokinetic	NOUN
admet-194	127	10	and	and	CCONJ
admet-194	127	11	pharmacodynamics	pharmacodynamic	NOUN
admet-194	127	12	of	of	ADP
admet-194	127	13	gsk-933776	gsk-933776	NOUN
admet-194	127	14	were	be	AUX
admet-194	127	15	investigated	investigate	VERB
admet-194	127	16	by	by	ADP
admet-194	127	17	two	two	NUM
admet-194	127	18	phase	phase	NOUN
admet-194	127	19	1	1	NUM
admet-194	127	20	trials	trial	NOUN
admet-194	127	21	with	with	ADP
admet-194	127	22	positive	positive	ADJ
admet-194	127	23	results	result	NOUN
admet-194	127	24	[	[	X
admet-194	127	25	65	65	NUM
admet-194	127	26	,	,	PUNCT
admet-194	127	27	66	66	NUM
admet-194	127	28	]	]	PUNCT
admet-194	127	29	.	.	PUNCT
admet-194	128	1	further	further	ADJ
admet-194	128	2	clinical	clinical	ADJ
admet-194	128	3	study	study	NOUN
admet-194	128	4	is	be	AUX
admet-194	128	5	expected	expect	VERB
admet-194	128	6	to	to	PART
admet-194	128	7	take	take	VERB
admet-194	128	8	place	place	NOUN
admet-194	128	9	in	in	ADP
admet-194	128	10	due	due	ADJ
admet-194	128	11	course	course	NOUN
admet-194	128	12	.	.	PUNCT
admet-194	129	1	natural	natural	ADJ
admet-194	129	2	anti	anti	ADJ
admet-194	129	3	-	-	ADJ
admet-194	129	4	amyloid	amyloid	ADJ
admet-194	129	5	antibodies	antibody	NOUN
admet-194	129	6	have	have	AUX
admet-194	129	7	been	be	AUX
admet-194	129	8	identified	identify	VERB
admet-194	129	9	in	in	ADP
admet-194	129	10	human	human	PROPN
admet-194	129	11	intravenous	intravenous	ADJ
admet-194	129	12	ivig	ivig	NOUN
admet-194	129	13	,	,	PUNCT
admet-194	129	14	which	which	PRON
admet-194	129	15	were	be	AUX
admet-194	129	16	isolated	isolate	VERB
admet-194	129	17	from	from	ADP
admet-194	129	18	pooled	pool	VERB
admet-194	129	19	plasma	plasma	NOUN
admet-194	129	20	of	of	ADP
admet-194	129	21	healthy	healthy	ADJ
admet-194	129	22	blood	blood	NOUN
admet-194	129	23	donors	donor	NOUN
admet-194	129	24	.	.	PUNCT
admet-194	130	1	a	a	DET
admet-194	130	2	phase	phase	NOUN
admet-194	130	3	1	1	NUM
admet-194	130	4	trial	trial	NOUN
admet-194	130	5	has	have	AUX
admet-194	130	6	been	be	AUX
admet-194	130	7	carried	carry	VERB
admet-194	130	8	out	out	ADP
admet-194	130	9	with	with	ADP
admet-194	130	10	eight	eight	NUM
admet-194	130	11	patients	patient	NOUN
admet-194	130	12	treated	treat	VERB
admet-194	130	13	with	with	ADP
admet-194	130	14	ivig	ivig	NOUN
admet-194	130	15	,	,	PUNCT
admet-194	130	16	and	and	CCONJ
admet-194	130	17	been	be	AUX
admet-194	130	18	completed	complete	VERB
admet-194	130	19	with	with	ADP
admet-194	130	20	seven	seven	NUM
admet-194	130	21	patients	patient	NOUN
admet-194	130	22	.	.	PUNCT
admet-194	131	1	the	the	DET
admet-194	131	2	exciting	exciting	ADJ
admet-194	131	3	results	result	NOUN
admet-194	131	4	showed	show	VERB
admet-194	131	5	that	that	SCONJ
admet-194	131	6	ivig	ivig	NOUN
admet-194	131	7	prevented	prevent	VERB
admet-194	131	8	the	the	DET
admet-194	131	9	decline	decline	NOUN
admet-194	131	10	of	of	ADP
admet-194	131	11	cognitive	cognitive	ADJ
admet-194	131	12	function	function	NOUN
admet-194	131	13	in	in	ADP
admet-194	131	14	all	all	DET
admet-194	131	15	seven	seven	NUM
admet-194	131	16	patients	patient	NOUN
admet-194	131	17	and	and	CCONJ
admet-194	131	18	even	even	ADV
admet-194	131	19	improved	improved	ADJ
admet-194	131	20	cognition	cognition	NOUN
admet-194	131	21	in	in	ADP
admet-194	131	22	six	six	NUM
admet-194	132	1	[	[	NOUN
admet-194	132	2	67	67	NUM
admet-194	132	3	]	]	PUNCT
admet-194	132	4	.	.	PUNCT
admet-194	133	1	a	a	DET
admet-194	133	2	phase	phase	NOUN
admet-194	133	3	3	3	NUM
admet-194	133	4	clinical	clinical	ADJ
admet-194	133	5	study	study	NOUN
admet-194	133	6	with	with	ADP
admet-194	133	7	more	more	ADJ
admet-194	133	8	than	than	ADP
admet-194	133	9	360	360	NUM
admet-194	133	10	ad	ad	NOUN
admet-194	133	11	patients	patient	NOUN
admet-194	133	12	was	be	AUX
admet-194	133	13	started	start	VERB
admet-194	133	14	in	in	ADP
admet-194	133	15	2009	2009	NUM
admet-194	133	16	.	.	PUNCT
admet-194	134	1	the	the	DET
admet-194	134	2	results	result	NOUN
admet-194	134	3	from	from	ADP
admet-194	134	4	this	this	DET
admet-194	134	5	clinical	clinical	ADJ
admet-194	134	6	trial	trial	NOUN
admet-194	134	7	may	may	AUX
admet-194	134	8	provide	provide	VERB
admet-194	134	9	conclusive	conclusive	ADJ
admet-194	134	10	evidence	evidence	NOUN
admet-194	134	11	as	as	ADP
admet-194	134	12	to	to	ADP
admet-194	134	13	whether	whether	SCONJ
admet-194	134	14	ivig	ivig	NOUN
admet-194	134	15	can	can	AUX
admet-194	134	16	be	be	AUX
admet-194	134	17	used	use	VERB
admet-194	134	18	as	as	ADP
admet-194	134	19	a	a	DET
admet-194	134	20	treatment	treatment	NOUN
admet-194	134	21	option	option	NOUN
admet-194	134	22	for	for	ADP
admet-194	134	23	ad	ad	NOUN
admet-194	134	24	[	[	X
admet-194	134	25	67	67	NUM
admet-194	134	26	]	]	PUNCT
admet-194	134	27	.	.	PUNCT
admet-194	135	1	2.1.1.2.2	2.1.1.2.2	NUM
admet-194	135	2	aβ	aβ	ADV
admet-194	135	3	-	-	PUNCT
admet-194	135	4	degrading	degrade	VERB
admet-194	135	5	enzymes	enzyme	NOUN
admet-194	135	6	recent	recent	ADJ
admet-194	135	7	studies	study	NOUN
admet-194	135	8	have	have	AUX
admet-194	135	9	showed	show	VERB
admet-194	135	10	that	that	SCONJ
admet-194	135	11	the	the	DET
admet-194	135	12	decreased	decrease	VERB
admet-194	135	13	clearance	clearance	NOUN
admet-194	135	14	of	of	ADP
admet-194	135	15	aβ	aβ	DET
admet-194	135	16	peptide	peptide	NOUN
admet-194	135	17	played	play	VERB
admet-194	135	18	a	a	DET
admet-194	135	19	more	more	ADV
admet-194	135	20	important	important	ADJ
admet-194	135	21	role	role	NOUN
admet-194	135	22	than	than	ADP
admet-194	135	23	its	its	PRON
admet-194	135	24	increased	increase	VERB
admet-194	135	25	production	production	NOUN
admet-194	135	26	in	in	ADP
admet-194	135	27	sporadic	sporadic	ADJ
admet-194	135	28	ad	ad	NOUN
admet-194	135	29	[	[	X
admet-194	135	30	68	68	NUM
admet-194	135	31	,	,	PUNCT
admet-194	135	32	69	69	NUM
admet-194	135	33	]	]	PUNCT
admet-194	135	34	,	,	PUNCT
admet-194	135	35	and	and	CCONJ
admet-194	135	36	the	the	DET
admet-194	135	37	way	way	NOUN
admet-194	135	38	to	to	PART
admet-194	135	39	upgrade	upgrade	VERB
admet-194	135	40	or	or	CCONJ
admet-194	135	41	activate	activate	VERB
admet-194	135	42	aβ	aβ	PRON
admet-194	135	43	-	-	PUNCT
admet-194	135	44	degrading	degrade	VERB
admet-194	135	45	enzymes	enzyme	NOUN
admet-194	135	46	would	would	AUX
admet-194	135	47	be	be	AUX
admet-194	135	48	another	another	DET
admet-194	135	49	potential	potential	ADJ
admet-194	135	50	approach	approach	NOUN
admet-194	135	51	to	to	PART
admet-194	135	52	conquer	conquer	VERB
admet-194	135	53	ad	ad	NOUN
admet-194	135	54	.	.	PUNCT
admet-194	136	1	several	several	ADJ
admet-194	136	2	proteinases	proteinase	NOUN
admet-194	136	3	,	,	PUNCT
admet-194	136	4	such	such	ADJ
admet-194	136	5	as	as	ADP
admet-194	136	6	,	,	PUNCT
admet-194	136	7	neprilysin	neprilysin	NOUN
admet-194	136	8	(	(	PUNCT
admet-194	136	9	nep	nep	NOUN
admet-194	136	10	)	)	PUNCT
admet-194	137	1	[	[	X
admet-194	137	2	70	70	NUM
admet-194	137	3	,	,	PUNCT
admet-194	137	4	71	71	NUM
admet-194	137	5	]	]	PUNCT
admet-194	137	6	,	,	PUNCT
admet-194	137	7	angiotensin	angiotensin	NOUN
admet-194	137	8	-	-	PUNCT
admet-194	137	9	converting	convert	VERB
admet-194	137	10	enzyme	enzyme	NOUN
admet-194	137	11	(	(	PUNCT
admet-194	137	12	ace	ace	NOUN
admet-194	137	13	)	)	PUNCT
admet-194	138	1	[	[	X
admet-194	138	2	1	1	NUM
admet-194	138	3	]	]	PUNCT
admet-194	138	4	,	,	PUNCT
admet-194	138	5	plasmin	plasmin	NOUN
admet-194	138	6	[	[	X
admet-194	138	7	1	1	NUM
admet-194	138	8	]	]	PUNCT
admet-194	138	9	,	,	PUNCT
admet-194	138	10	insulin	insulin	NOUN
admet-194	138	11	degrading	degrade	VERB
admet-194	138	12	enzyme	enzyme	NOUN
admet-194	138	13	(	(	PUNCT
admet-194	138	14	ide	ide	NOUN
admet-194	138	15	)	)	PUNCT
admet-194	138	16	[	[	X
admet-194	138	17	1	1	NUM
admet-194	138	18	]	]	PUNCT
admet-194	138	19	,	,	PUNCT
admet-194	138	20	and	and	CCONJ
admet-194	138	21	endothelin	endothelin	PROPN
admet-194	138	22	converting	convert	VERB
admet-194	138	23	enzyme	enzyme	NOUN
admet-194	138	24	(	(	PUNCT
admet-194	138	25	ece	ece	PROPN
admet-194	138	26	)	)	PUNCT
admet-194	138	27	1	1	NUM
admet-194	138	28	and	and	CCONJ
admet-194	138	29	2	2	NUM
admet-194	139	1	[	[	X
admet-194	139	2	1	1	NUM
admet-194	139	3	]	]	PUNCT
admet-194	139	4	,	,	PUNCT
admet-194	139	5	were	be	AUX
admet-194	139	6	shown	show	VERB
admet-194	139	7	to	to	PART
admet-194	139	8	be	be	AUX
admet-194	139	9	able	able	ADJ
admet-194	139	10	to	to	PART
admet-194	139	11	degrade	degrade	VERB
admet-194	139	12	aβ	aβ	DET
admet-194	139	13	peptides	peptide	NOUN
admet-194	139	14	in	in	ADP
admet-194	139	15	vitro	vitro	X
admet-194	139	16	or	or	CCONJ
admet-194	139	17	in	in	ADP
admet-194	139	18	animal	animal	NOUN
admet-194	139	19	models	model	NOUN
admet-194	139	20	.	.	PUNCT
admet-194	140	1	2.1.1.3	2.1.1.3	NUM
admet-194	140	2	suppression	suppression	NOUN
admet-194	140	3	of	of	ADP
admet-194	140	4	aβ	aβ	PRON
admet-194	140	5	aggregation	aggregation	NOUN
admet-194	140	6	jing	jing	PROPN
admet-194	140	7	li	li	PROPN
admet-194	140	8	et	et	PROPN
admet-194	140	9	al	al	PROPN
admet-194	140	10	.	.	PROPN
admet-194	140	11	admet	admet	PROPN
admet-194	140	12	&	&	CCONJ
admet-194	140	13	dmpk	dmpk	PROPN
admet-194	140	14	3(3	3(3	NUM
admet-194	140	15	)	)	PUNCT
admet-194	140	16	(	(	PUNCT
admet-194	140	17	2015	2015	NUM
admet-194	140	18	)	)	PUNCT
admet-194	140	19	216	216	NUM
admet-194	140	20	-	-	SYM
admet-194	140	21	234	234	NUM
admet-194	140	22	222	222	NUM
admet-194	140	23	the	the	DET
admet-194	140	24	aβ	aβ	NOUN
admet-194	140	25	-	-	PUNCT
admet-194	140	26	induced	induce	VERB
admet-194	140	27	neurotoxicity	neurotoxicity	NOUN
admet-194	140	28	has	have	AUX
admet-194	140	29	been	be	AUX
admet-194	140	30	shown	show	VERB
admet-194	140	31	on	on	ADP
admet-194	140	32	a	a	DET
admet-194	140	33	number	number	NOUN
admet-194	140	34	of	of	ADP
admet-194	140	35	occasions	occasion	NOUN
admet-194	140	36	.	.	PUNCT
admet-194	141	1	potentially	potentially	ADV
admet-194	141	2	it	it	PRON
admet-194	141	3	may	may	AUX
admet-194	141	4	be	be	AUX
admet-194	141	5	possible	possible	ADJ
admet-194	141	6	to	to	PART
admet-194	141	7	elicit	elicit	VERB
admet-194	141	8	a	a	DET
admet-194	141	9	therapeutic	therapeutic	ADJ
admet-194	141	10	effect	effect	NOUN
admet-194	141	11	by	by	ADP
admet-194	141	12	inhibiting	inhibit	VERB
admet-194	141	13	the	the	DET
admet-194	141	14	aβ	aβ	NOUN
admet-194	141	15	peptide	peptide	NOUN
admet-194	141	16	aggregation	aggregation	NOUN
admet-194	141	17	.	.	PUNCT
admet-194	142	1	as	as	ADP
admet-194	142	2	the	the	DET
admet-194	142	3	only	only	ADJ
admet-194	142	4	aggregation	aggregation	NOUN
admet-194	142	5	inhibitor	inhibitor	NOUN
admet-194	142	6	entering	enter	VERB
admet-194	142	7	phase	phase	NOUN
admet-194	142	8	3	3	NUM
admet-194	142	9	trial	trial	NOUN
admet-194	142	10	,	,	PUNCT
admet-194	142	11	tramiprosate	tramiprosate	VERB
admet-194	142	12	(	(	PUNCT
admet-194	142	13	3aps	3ap	NOUN
admet-194	142	14	)	)	PUNCT
admet-194	142	15	showed	show	VERB
admet-194	142	16	negative	negative	ADJ
admet-194	142	17	clinical	clinical	ADJ
admet-194	142	18	efficacy	efficacy	NOUN
admet-194	142	19	,	,	PUNCT
admet-194	142	20	which	which	PRON
admet-194	142	21	resulted	result	VERB
admet-194	142	22	in	in	ADP
admet-194	142	23	the	the	DET
admet-194	142	24	discontinuation	discontinuation	NOUN
admet-194	142	25	of	of	ADP
admet-194	142	26	clinical	clinical	ADJ
admet-194	142	27	trial	trial	NOUN
admet-194	142	28	of	of	ADP
admet-194	142	29	this	this	DET
admet-194	142	30	drug	drug	NOUN
admet-194	142	31	[	[	X
admet-194	142	32	72	72	NUM
admet-194	142	33	]	]	PUNCT
admet-194	142	34	.	.	PUNCT
admet-194	143	1	though	though	SCONJ
admet-194	143	2	showing	show	VERB
admet-194	143	3	positive	positive	ADJ
admet-194	143	4	results	result	NOUN
admet-194	143	5	in	in	ADP
admet-194	143	6	phase	phase	NOUN
admet-194	143	7	2	2	NUM
admet-194	143	8	trials	trial	NOUN
admet-194	143	9	,	,	PUNCT
admet-194	143	10	the	the	DET
admet-194	143	11	development	development	NOUN
admet-194	143	12	of	of	ADP
admet-194	143	13	clioquinol	clioquinol	PROPN
admet-194	143	14	(	(	PUNCT
admet-194	143	15	pbt1	pbt1	PROPN
admet-194	143	16	)	)	PUNCT
admet-194	143	17	was	be	AUX
admet-194	143	18	suspended	suspend	VERB
admet-194	143	19	by	by	ADP
admet-194	143	20	its	its	PRON
admet-194	143	21	manufacturer	manufacturer	NOUN
admet-194	143	22	[	[	X
admet-194	143	23	73	73	NUM
admet-194	143	24	]	]	PUNCT
admet-194	143	25	.	.	PUNCT
admet-194	144	1	another	another	DET
admet-194	144	2	compound	compound	NOUN
admet-194	144	3	with	with	ADP
admet-194	144	4	the	the	DET
admet-194	144	5	same	same	ADJ
admet-194	144	6	production	production	NOUN
admet-194	144	7	line	line	NOUN
admet-194	144	8	,	,	PUNCT
admet-194	144	9	pbt2	pbt2	PROPN
admet-194	144	10	,	,	PUNCT
admet-194	144	11	failed	fail	VERB
admet-194	144	12	to	to	PART
admet-194	144	13	achieve	achieve	VERB
admet-194	144	14	its	its	PRON
admet-194	144	15	targets	target	NOUN
admet-194	144	16	in	in	ADP
admet-194	144	17	phase	phase	NOUN
admet-194	144	18	2	2	NUM
admet-194	144	19	trials	trial	NOUN
admet-194	144	20	,	,	PUNCT
admet-194	144	21	and	and	CCONJ
admet-194	144	22	failed	fail	VERB
admet-194	144	23	to	to	PART
admet-194	144	24	show	show	VERB
admet-194	144	25	any	any	DET
admet-194	144	26	benefits	benefit	NOUN
admet-194	144	27	[	[	X
admet-194	144	28	74	74	NUM
admet-194	144	29	,	,	PUNCT
admet-194	144	30	75	75	NUM
admet-194	144	31	]	]	PUNCT
admet-194	144	32	.	.	PUNCT
admet-194	145	1	primary	primary	ADJ
admet-194	145	2	clinical	clinical	ADJ
admet-194	145	3	efficacy	efficacy	NOUN
admet-194	145	4	outcomes	outcome	NOUN
admet-194	145	5	of	of	ADP
admet-194	145	6	a	a	DET
admet-194	145	7	phase	phase	NOUN
admet-194	145	8	2	2	NUM
admet-194	145	9	trial	trial	NOUN
admet-194	145	10	of	of	ADP
admet-194	145	11	another	another	DET
admet-194	145	12	compound	compound	NOUN
admet-194	145	13	,	,	PUNCT
admet-194	145	14	elnd005	elnd005	PROPN
admet-194	145	15	(	(	PUNCT
admet-194	145	16	scylloinositol	scylloinositol	PROPN
admet-194	145	17	)	)	PUNCT
admet-194	145	18	,	,	PUNCT
admet-194	145	19	were	be	AUX
admet-194	145	20	not	not	PART
admet-194	145	21	significant	significant	ADJ
admet-194	145	22	[	[	X
admet-194	145	23	76	76	NUM
admet-194	145	24	]	]	PUNCT
admet-194	145	25	.	.	PUNCT
admet-194	146	1	2.1.1.4	2.1.1.4	NUM
admet-194	146	2	raising	raise	VERB
admet-194	146	3	brain	brain	NOUN
admet-194	146	4	resistance	resistance	NOUN
admet-194	146	5	to	to	ADP
admet-194	146	6	aβ	aβ	PRON
admet-194	146	7	for	for	ADP
admet-194	146	8	increasing	increase	VERB
admet-194	146	9	brain	brain	NOUN
admet-194	146	10	resistance	resistance	NOUN
admet-194	146	11	to	to	ADP
admet-194	146	12	aβ	aβ	PROPN
admet-194	146	13	,	,	PUNCT
admet-194	146	14	one	one	NUM
admet-194	146	15	target	target	NOUN
admet-194	146	16	is	be	AUX
admet-194	146	17	the	the	DET
admet-194	146	18	group	group	NOUN
admet-194	146	19	iv	iv	NUM
admet-194	146	20	phospholipase	phospholipase	NOUN
admet-194	146	21	a2	a2	PROPN
admet-194	146	22	(	(	PUNCT
admet-194	146	23	giva	giva	X
admet-194	146	24	-	-	PUNCT
admet-194	146	25	pla2	pla2	PROPN
admet-194	146	26	)	)	PUNCT
admet-194	146	27	,	,	PUNCT
admet-194	146	28	which	which	PRON
admet-194	146	29	is	be	AUX
admet-194	146	30	involved	involve	VERB
admet-194	146	31	in	in	ADP
admet-194	146	32	neurovirulence	neurovirulence	NOUN
admet-194	146	33	of	of	ADP
admet-194	146	34	aβ	aβ	PROPN
admet-194	146	35	.	.	PUNCT
admet-194	147	1	studies	study	NOUN
admet-194	147	2	showed	show	VERB
admet-194	147	3	genetic	genetic	ADJ
admet-194	147	4	reduction	reduction	NOUN
admet-194	147	5	or	or	CCONJ
admet-194	147	6	ablation	ablation	NOUN
admet-194	147	7	of	of	ADP
admet-194	147	8	giva	giva	NOUN
admet-194	147	9	-	-	PUNCT
admet-194	147	10	pla2	pla2	PROPN
admet-194	147	11	inhibits	inhibits	AUX
admet-194	147	12	aβinduced	aβinduce	VERB
admet-194	147	13	cognitive	cognitive	ADJ
admet-194	147	14	deficit	deficit	NOUN
admet-194	147	15	in	in	ADP
admet-194	147	16	animal	animal	NOUN
admet-194	147	17	models	model	NOUN
admet-194	147	18	[	[	X
admet-194	147	19	77	77	NUM
admet-194	147	20	]	]	PUNCT
admet-194	147	21	.	.	PUNCT
admet-194	148	1	however	however	ADV
admet-194	148	2	specific	specific	ADJ
admet-194	148	3	drugs	drug	NOUN
admet-194	148	4	to	to	PART
admet-194	148	5	inhibit	inhibit	VERB
admet-194	148	6	giva	giva	NOUN
admet-194	148	7	-	-	PUNCT
admet-194	148	8	pla2	pla2	NOUN
admet-194	148	9	remain	remain	VERB
admet-194	148	10	to	to	PART
admet-194	148	11	be	be	AUX
admet-194	148	12	confirmed	confirm	VERB
admet-194	148	13	.	.	PUNCT
admet-194	149	1	the	the	DET
admet-194	149	2	other	other	ADJ
admet-194	149	3	target	target	NOUN
admet-194	149	4	is	be	AUX
admet-194	149	5	tau	tau	NOUN
admet-194	149	6	protein	protein	NOUN
admet-194	149	7	level	level	NOUN
admet-194	149	8	since	since	SCONJ
admet-194	149	9	it	it	PRON
admet-194	149	10	may	may	AUX
admet-194	149	11	involve	involve	VERB
admet-194	149	12	the	the	DET
admet-194	149	13	mediation	mediation	NOUN
admet-194	149	14	of	of	ADP
admet-194	149	15	aβ	aβ	NOUN
admet-194	149	16	-	-	PUNCT
admet-194	149	17	dependent	dependent	ADJ
admet-194	149	18	neuronal	neuronal	ADJ
admet-194	149	19	dysfunction	dysfunction	NOUN
admet-194	149	20	.	.	PUNCT
admet-194	150	1	it	it	PRON
admet-194	150	2	has	have	AUX
admet-194	150	3	been	be	AUX
admet-194	150	4	showed	show	VERB
admet-194	150	5	that	that	SCONJ
admet-194	150	6	genetic	genetic	ADJ
admet-194	150	7	reduction	reduction	NOUN
admet-194	150	8	or	or	CCONJ
admet-194	150	9	ablation	ablation	NOUN
admet-194	150	10	of	of	ADP
admet-194	150	11	tau	tau	PROPN
admet-194	150	12	suppresses	suppress	VERB
admet-194	150	13	aβ	aβ	ADV
admet-194	150	14	-	-	PUNCT
admet-194	150	15	induced	induce	VERB
admet-194	150	16	cognitive	cognitive	ADJ
admet-194	150	17	deficit	deficit	NOUN
admet-194	150	18	,	,	PUNCT
admet-194	150	19	but	but	CCONJ
admet-194	150	20	does	do	AUX
admet-194	150	21	not	not	PART
admet-194	150	22	affect	affect	VERB
admet-194	150	23	the	the	DET
admet-194	150	24	plaque	plaque	NOUN
admet-194	150	25	burden	burden	NOUN
admet-194	150	26	or	or	CCONJ
admet-194	150	27	aβ	aβ	PRON
admet-194	150	28	oligomer	oligomer	ADJ
admet-194	150	29	levels	level	NOUN
admet-194	150	30	in	in	ADP
admet-194	150	31	animal	animal	NOUN
admet-194	150	32	models	model	NOUN
admet-194	150	33	[	[	X
admet-194	150	34	78	78	NUM
admet-194	150	35	]	]	PUNCT
admet-194	150	36	.	.	PUNCT
admet-194	151	1	2.1.2	2.1.2	NUM
admet-194	151	2	tau	tau	ADV
admet-194	151	3	-	-	PUNCT
admet-194	151	4	targeting	target	VERB
admet-194	151	5	strategies	strategy	NOUN
admet-194	151	6	tau	tau	NOUN
admet-194	151	7	protein	protein	NOUN
admet-194	151	8	is	be	AUX
admet-194	151	9	a	a	DET
admet-194	151	10	cytoplasmatic	cytoplasmatic	ADJ
admet-194	151	11	microtubule	microtubule	NOUN
admet-194	151	12	-	-	PUNCT
admet-194	151	13	associated	associate	VERB
admet-194	151	14	protein	protein	NOUN
admet-194	151	15	that	that	PRON
admet-194	151	16	is	be	AUX
admet-194	151	17	more	more	ADV
admet-194	151	18	frequently	frequently	ADV
admet-194	151	19	found	find	VERB
admet-194	151	20	in	in	ADP
admet-194	151	21	neurons	neuron	NOUN
admet-194	151	22	than	than	ADP
admet-194	151	23	non	non	ADJ
admet-194	151	24	-	-	ADJ
admet-194	151	25	neuronal	neuronal	ADJ
admet-194	151	26	cells	cell	NOUN
admet-194	151	27	[	[	X
admet-194	151	28	79	79	NUM
admet-194	151	29	]	]	PUNCT
admet-194	151	30	.	.	PUNCT
admet-194	152	1	the	the	DET
admet-194	152	2	main	main	ADJ
admet-194	152	3	function	function	NOUN
admet-194	152	4	of	of	ADP
admet-194	152	5	tau	tau	PROPN
admet-194	152	6	is	be	AUX
admet-194	152	7	stabilizing	stabilize	VERB
admet-194	152	8	axonal	axonal	ADJ
admet-194	152	9	microtubules	microtubule	NOUN
admet-194	152	10	through	through	ADP
admet-194	152	11	interacting	interact	VERB
admet-194	152	12	with	with	ADP
admet-194	152	13	tubulin	tubulin	NOUN
admet-194	152	14	during	during	ADP
admet-194	152	15	its	its	PRON
admet-194	152	16	polymerization	polymerization	NOUN
admet-194	152	17	[	[	X
admet-194	152	18	80	80	NUM
admet-194	152	19	]	]	PUNCT
admet-194	152	20	.	.	PUNCT
admet-194	153	1	abnormally	abnormally	ADV
admet-194	153	2	hyperphosphorylated	hyperphosphorylate	VERB
admet-194	153	3	tau	tau	PROPN
admet-194	153	4	develops	develop	VERB
admet-194	153	5	the	the	DET
admet-194	153	6	paired	pair	VERB
admet-194	153	7	helical	helical	ADJ
admet-194	153	8	filaments	filament	NOUN
admet-194	153	9	(	(	PUNCT
admet-194	153	10	phf	phf	NOUN
admet-194	153	11	)	)	PUNCT
admet-194	153	12	,	,	PUNCT
admet-194	153	13	which	which	PRON
admet-194	153	14	has	have	VERB
admet-194	153	15	severe	severe	ADJ
admet-194	153	16	toxicity	toxicity	NOUN
admet-194	153	17	impairing	impair	VERB
admet-194	153	18	axonal	axonal	ADJ
admet-194	153	19	transport	transport	NOUN
admet-194	153	20	gravely	gravely	ADV
admet-194	153	21	.	.	PUNCT
admet-194	154	1	tau	tau	PROPN
admet-194	154	2	hypothesis	hypothesis	NOUN
admet-194	154	3	is	be	AUX
admet-194	154	4	the	the	DET
admet-194	154	5	main	main	ADJ
admet-194	154	6	competitor	competitor	NOUN
admet-194	154	7	of	of	ADP
admet-194	154	8	the	the	DET
admet-194	154	9	aβ	aβ	PROPN
admet-194	154	10	hypothesis	hypothesis	NOUN
admet-194	154	11	in	in	ADP
admet-194	154	12	ad	ad	NOUN
admet-194	154	13	pathologies	pathology	NOUN
admet-194	154	14	[	[	X
admet-194	154	15	81	81	NUM
admet-194	154	16	]	]	PUNCT
admet-194	154	17	,	,	PUNCT
admet-194	154	18	but	but	CCONJ
admet-194	154	19	it	it	PRON
admet-194	154	20	is	be	AUX
admet-194	154	21	also	also	ADV
admet-194	154	22	interacts	interact	VERB
admet-194	154	23	with	with	ADP
admet-194	154	24	aβ	aβ	NOUN
admet-194	154	25	cascade	cascade	NOUN
admet-194	154	26	.	.	PUNCT
admet-194	155	1	the	the	DET
admet-194	155	2	strategies	strategy	NOUN
admet-194	155	3	concentrated	concentrate	VERB
admet-194	155	4	on	on	ADP
admet-194	155	5	tau	tau	PROPN
admet-194	155	6	protein	protein	NOUN
admet-194	155	7	mainly	mainly	ADV
admet-194	155	8	based	base	VERB
admet-194	155	9	on	on	ADP
admet-194	155	10	its	its	PRON
admet-194	155	11	phosphorylation	phosphorylation	NOUN
admet-194	155	12	,	,	PUNCT
admet-194	155	13	aggregation	aggregation	NOUN
admet-194	155	14	and	and	CCONJ
admet-194	155	15	misfolding	misfolding	NOUN
admet-194	155	16	.	.	PUNCT
admet-194	156	1	2.1.2.1	2.1.2.1	NUM
admet-194	156	2	prevention	prevention	NOUN
admet-194	156	3	of	of	ADP
admet-194	156	4	tau	tau	PROPN
admet-194	156	5	phosphorylation	phosphorylation	NOUN
admet-194	156	6	the	the	DET
admet-194	156	7	phosphorylation	phosphorylation	NOUN
admet-194	156	8	of	of	ADP
admet-194	156	9	tau	tau	PROPN
admet-194	156	10	protein	protein	NOUN
admet-194	156	11	,	,	PUNCT
admet-194	156	12	which	which	PRON
admet-194	156	13	mainly	mainly	ADV
admet-194	156	14	mediated	mediate	VERB
admet-194	156	15	by	by	ADP
admet-194	156	16	microtubule	microtubule	NOUN
admet-194	156	17	-	-	PUNCT
admet-194	156	18	associated	associate	VERB
admet-194	156	19	regulatory	regulatory	ADJ
admet-194	156	20	kinase	kinase	PROPN
admet-194	156	21	(	(	PUNCT
admet-194	156	22	mark	mark	PROPN
admet-194	156	23	)	)	PUNCT
admet-194	156	24	,	,	PUNCT
admet-194	156	25	cyclin	cyclin	NOUN
admet-194	156	26	-	-	PUNCT
admet-194	156	27	dependent	dependent	ADJ
admet-194	156	28	kinase-5	kinase-5	PROPN
admet-194	156	29	(	(	PUNCT
admet-194	156	30	cdk5	cdk5	PROPN
admet-194	156	31	)	)	PUNCT
admet-194	156	32	,	,	PUNCT
admet-194	156	33	and	and	CCONJ
admet-194	156	34	glycogen	glycogen	NOUN
admet-194	156	35	synthase	synthase	NOUN
admet-194	156	36	kinase	kinase	PROPN
admet-194	156	37	3β	3β	PROPN
admet-194	156	38	(	(	PUNCT
admet-194	156	39	gsk-3β	gsk-3β	PROPN
admet-194	156	40	)	)	PUNCT
admet-194	156	41	,	,	PUNCT
admet-194	156	42	increases	increase	VERB
admet-194	156	43	dramatically	dramatically	ADV
admet-194	156	44	in	in	ADP
admet-194	156	45	ad	ad	NOUN
admet-194	156	46	patients	patient	NOUN
admet-194	156	47	[	[	X
admet-194	156	48	82	82	NUM
admet-194	156	49	,	,	PUNCT
admet-194	156	50	83	83	NUM
admet-194	156	51	]	]	PUNCT
admet-194	156	52	,	,	PUNCT
admet-194	156	53	showing	show	VERB
admet-194	156	54	that	that	SCONJ
admet-194	156	55	the	the	DET
admet-194	156	56	inhibitors	inhibitor	NOUN
admet-194	156	57	of	of	ADP
admet-194	156	58	tau	tau	PROPN
admet-194	156	59	kinases	kinase	NOUN
admet-194	156	60	could	could	AUX
admet-194	156	61	have	have	VERB
admet-194	156	62	the	the	DET
admet-194	156	63	ability	ability	NOUN
admet-194	156	64	of	of	ADP
admet-194	156	65	antiad	antiad	PROPN
admet-194	156	66	.	.	PUNCT
admet-194	157	1	valproate	valproate	ADJ
admet-194	157	2	(	(	PUNCT
admet-194	157	3	vpa	vpa	PROPN
admet-194	157	4	)	)	PUNCT
admet-194	157	5	showed	show	VERB
admet-194	157	6	its	its	PRON
admet-194	157	7	inhibitory	inhibitory	ADJ
admet-194	157	8	effects	effect	NOUN
admet-194	157	9	on	on	ADP
admet-194	157	10	tau	tau	PROPN
admet-194	157	11	hyperphosphorylation	hyperphosphorylation	NOUN
admet-194	157	12	in	in	ADP
admet-194	157	13	both	both	DET
admet-194	157	14	ad	ad	NOUN
admet-194	157	15	transgenic	transgenic	NOUN
admet-194	157	16	mice	mouse	NOUN
admet-194	157	17	and	and	CCONJ
admet-194	157	18	sh	sh	NOUN
admet-194	157	19	-	-	PUNCT
admet-194	157	20	sy5y	sy5y	PROPN
admet-194	157	21	cell	cell	NOUN
admet-194	157	22	model	model	NOUN
admet-194	157	23	,	,	PUNCT
admet-194	157	24	which	which	PRON
admet-194	157	25	might	might	AUX
admet-194	157	26	be	be	AUX
admet-194	157	27	realized	realize	VERB
admet-194	157	28	through	through	ADP
admet-194	157	29	both	both	PRON
admet-194	157	30	regulating	regulate	VERB
admet-194	157	31	gsk3β	gsk3β	PROPN
admet-194	157	32	and	and	CCONJ
admet-194	157	33	cdk5	cdk5	PROPN
admet-194	157	34	signalling	signal	VERB
admet-194	157	35	pathways	pathway	NOUN
admet-194	157	36	[	[	X
admet-194	157	37	84	84	NUM
admet-194	157	38	]	]	PUNCT
admet-194	157	39	.	.	PUNCT
admet-194	158	1	as	as	SCONJ
admet-194	158	2	the	the	DET
admet-194	158	3	first	first	ADJ
admet-194	158	4	drug	drug	NOUN
admet-194	158	5	aiming	aim	VERB
admet-194	158	6	at	at	ADP
admet-194	158	7	tau	tau	PROPN
admet-194	158	8	hyperphosphorylation	hyperphosphorylation	NOUN
admet-194	158	9	has	have	AUX
admet-194	158	10	entered	enter	VERB
admet-194	158	11	phase	phase	NOUN
admet-194	158	12	3	3	NUM
admet-194	158	13	trial	trial	NOUN
admet-194	158	14	,	,	PUNCT
admet-194	158	15	valproate	valproate	NOUN
admet-194	158	16	showed	show	VERB
admet-194	158	17	disappointingly	disappointingly	ADV
admet-194	158	18	negative	negative	ADJ
admet-194	158	19	results	result	NOUN
admet-194	158	20	for	for	ADP
admet-194	158	21	no	no	DET
admet-194	158	22	improvements	improvement	NOUN
admet-194	158	23	on	on	ADP
admet-194	158	24	cognitive	cognitive	ADJ
admet-194	158	25	and	and	CCONJ
admet-194	158	26	functional	functional	ADJ
admet-194	158	27	performance	performance	NOUN
admet-194	158	28	of	of	ADP
admet-194	158	29	ad	ad	NOUN
admet-194	158	30	patients	patient	NOUN
admet-194	158	31	[	[	X
admet-194	158	32	85	85	NUM
admet-194	158	33	,	,	PUNCT
admet-194	158	34	86	86	NUM
admet-194	158	35	]	]	PUNCT
admet-194	158	36	.	.	PUNCT
admet-194	159	1	the	the	DET
admet-194	159	2	most	most	ADV
admet-194	159	3	studied	study	VERB
admet-194	159	4	compound	compound	NOUN
admet-194	159	5	having	have	VERB
admet-194	159	6	capacity	capacity	NOUN
admet-194	159	7	of	of	ADP
admet-194	159	8	suppressing	suppress	VERB
admet-194	159	9	gsk3β	gsk3β	PROPN
admet-194	159	10	is	be	AUX
admet-194	159	11	lithium	lithium	NOUN
admet-194	159	12	[	[	X
admet-194	159	13	87	87	NUM
admet-194	159	14	]	]	PUNCT
admet-194	159	15	,	,	PUNCT
admet-194	159	16	but	but	CCONJ
admet-194	159	17	it	it	PRON
admet-194	159	18	did	do	AUX
admet-194	159	19	not	not	PART
admet-194	159	20	show	show	VERB
admet-194	159	21	its	its	PRON
admet-194	159	22	ability	ability	NOUN
admet-194	159	23	of	of	ADP
admet-194	159	24	improving	improve	VERB
admet-194	159	25	working	working	NOUN
admet-194	159	26	memory	memory	NOUN
admet-194	159	27	in	in	ADP
admet-194	159	28	aged	aged	ADJ
admet-194	159	29	3xtg	3xtg	PROPN
admet-194	159	30	-	-	PUNCT
admet-194	159	31	ad	ad	NOUN
admet-194	159	32	mice	mouse	NOUN
admet-194	159	33	[	[	X
admet-194	159	34	88	88	NUM
admet-194	159	35	]	]	PUNCT
admet-194	159	36	,	,	PUNCT
admet-194	159	37	so	so	ADV
admet-194	159	38	the	the	DET
admet-194	159	39	most	most	ADV
admet-194	159	40	efficacious	efficacious	ADJ
admet-194	159	41	treatment	treatment	NOUN
admet-194	159	42	might	might	AUX
admet-194	159	43	be	be	AUX
admet-194	159	44	the	the	DET
admet-194	159	45	combination	combination	NOUN
admet-194	159	46	of	of	ADP
admet-194	159	47	lithium	lithium	NOUN
admet-194	159	48	and	and	CCONJ
admet-194	159	49	other	other	ADJ
admet-194	159	50	anti	anti	ADJ
admet-194	159	51	-	-	ADJ
admet-194	159	52	aβ	aβ	ADJ
admet-194	159	53	interventions	intervention	NOUN
admet-194	159	54	.	.	PUNCT
admet-194	160	1	unfortunately	unfortunately	ADV
admet-194	160	2	,	,	PUNCT
admet-194	160	3	the	the	DET
admet-194	160	4	clinical	clinical	ADJ
admet-194	160	5	consequence	consequence	NOUN
admet-194	160	6	of	of	ADP
admet-194	160	7	a	a	DET
admet-194	160	8	phase	phase	NOUN
admet-194	160	9	2	2	NUM
admet-194	160	10	trial	trial	NOUN
admet-194	160	11	showed	show	VERB
admet-194	160	12	us	we	PRON
admet-194	160	13	the	the	DET
admet-194	160	14	negative	negative	ADJ
admet-194	160	15	side	side	NOUN
admet-194	160	16	of	of	ADP
admet-194	160	17	this	this	DET
admet-194	160	18	drug	drug	NOUN
admet-194	160	19	,	,	PUNCT
admet-194	160	20	which	which	PRON
admet-194	160	21	manifested	manifest	VERB
admet-194	160	22	no	no	DET
admet-194	160	23	effect	effect	NOUN
admet-194	160	24	on	on	ADP
admet-194	160	25	gsk-3	gsk-3	PUNCT
admet-194	160	26	activity	activity	NOUN
admet-194	160	27	and	and	CCONJ
admet-194	160	28	no	no	DET
admet-194	160	29	improvement	improvement	NOUN
admet-194	160	30	in	in	ADP
admet-194	160	31	global	global	ADJ
admet-194	160	32	cognitive	cognitive	ADJ
admet-194	160	33	performance	performance	NOUN
admet-194	160	34	[	[	X
admet-194	160	35	89	89	NUM
admet-194	160	36	]	]	PUNCT
admet-194	160	37	.	.	PUNCT
admet-194	161	1	besides	besides	SCONJ
admet-194	161	2	inhibiting	inhibit	VERB
admet-194	161	3	the	the	DET
admet-194	161	4	action	action	NOUN
admet-194	161	5	of	of	ADP
admet-194	161	6	mapk	mapk	NOUN
admet-194	161	7	,	,	PUNCT
admet-194	161	8	protein	protein	NOUN
admet-194	161	9	phosphatase	phosphatase	NOUN
admet-194	161	10	pp-2a	pp-2a	PROPN
admet-194	161	11	could	could	AUX
admet-194	161	12	also	also	ADV
admet-194	161	13	increase	increase	VERB
admet-194	161	14	tau	tau	PROPN
admet-194	161	15	dephosphorylation	dephosphorylation	NOUN
admet-194	161	16	.	.	PUNCT
admet-194	162	1	the	the	DET
admet-194	162	2	inhibitors	inhibitor	NOUN
admet-194	162	3	of	of	ADP
admet-194	162	4	cdk5	cdk5	PROPN
admet-194	162	5	seem	seem	VERB
admet-194	162	6	to	to	PART
admet-194	162	7	impair	impair	VERB
admet-194	162	8	the	the	DET
admet-194	162	9	development	development	NOUN
admet-194	162	10	of	of	ADP
admet-194	162	11	pathology	pathology	NOUN
admet-194	162	12	in	in	ADP
admet-194	162	13	tau	tau	PROPN
admet-194	162	14	transgenic	transgenic	NOUN
admet-194	162	15	mice	mouse	NOUN
admet-194	162	16	[	[	X
admet-194	162	17	90	90	NUM
admet-194	162	18	]	]	PUNCT
admet-194	162	19	.	.	PUNCT
admet-194	163	1	the	the	DET
admet-194	163	2	m1	m1	PROPN
admet-194	163	3	muscarinic	muscarinic	ADJ
admet-194	163	4	agonist	agonist	NOUN
admet-194	163	5	af267b	af267b	PROPN
admet-194	163	6	(	(	PUNCT
admet-194	163	7	ngx267	ngx267	PROPN
admet-194	163	8	)	)	PUNCT
admet-194	163	9	can	can	AUX
admet-194	163	10	inhibit	inhibit	VERB
admet-194	163	11	gsk-3β	gsk-3β	PROPN
admet-194	163	12	[	[	X
admet-194	163	13	1	1	NUM
admet-194	163	14	]	]	PUNCT
admet-194	163	15	.	.	PUNCT
admet-194	164	1	also	also	ADV
admet-194	164	2	,	,	PUNCT
admet-194	164	3	minocycline	minocycline	PROPN
admet-194	164	4	could	could	AUX
admet-194	164	5	inhibit	inhibit	VERB
admet-194	164	6	tau	tau	PROPN
admet-194	164	7	aggregation	aggregation	NOUN
admet-194	164	8	,	,	PUNCT
admet-194	164	9	which	which	PRON
admet-194	164	10	associated	associate	VERB
admet-194	164	11	with	with	ADP
admet-194	164	12	the	the	DET
admet-194	164	13	suppression	suppression	NOUN
admet-194	164	14	of	of	ADP
admet-194	164	15	aβ	aβ	ADV
admet-194	164	16	-	-	PUNCT
admet-194	164	17	induced	induce	VERB
admet-194	164	18	neuronal	neuronal	ADJ
admet-194	164	19	death	death	NOUN
admet-194	164	20	and	and	CCONJ
admet-194	164	21	cognitive	cognitive	ADJ
admet-194	164	22	impairment	impairment	NOUN
admet-194	164	23	in	in	ADP
admet-194	164	24	animal	animal	NOUN
admet-194	164	25	models	model	NOUN
admet-194	164	26	[	[	X
admet-194	164	27	91	91	NUM
admet-194	164	28	]	]	PUNCT
admet-194	164	29	.	.	PUNCT
admet-194	165	1	2.1.2.2	2.1.2.2	NUM
admet-194	165	2	prevention	prevention	NOUN
admet-194	165	3	of	of	ADP
admet-194	165	4	tau	tau	PROPN
admet-194	165	5	aggregation	aggregation	NOUN
admet-194	165	6	though	though	SCONJ
admet-194	165	7	it	it	PRON
admet-194	165	8	is	be	AUX
admet-194	165	9	an	an	DET
admet-194	165	10	ordinarily	ordinarily	ADV
admet-194	165	11	soluble	soluble	ADJ
admet-194	165	12	protein	protein	NOUN
admet-194	165	13	,	,	PUNCT
admet-194	165	14	tau	tau	PROPN
admet-194	165	15	forms	form	VERB
admet-194	165	16	insoluble	insoluble	ADJ
admet-194	165	17	,	,	PUNCT
admet-194	165	18	filamentous	filamentous	ADJ
admet-194	165	19	accumulation	accumulation	NOUN
admet-194	165	20	in	in	ADP
admet-194	165	21	the	the	DET
admet-194	165	22	course	course	NOUN
admet-194	165	23	of	of	ADP
admet-194	165	24	nfts	nft	NOUN
admet-194	165	25	formation	formation	NOUN
admet-194	165	26	.	.	PUNCT
admet-194	166	1	inhibitors	inhibitor	NOUN
admet-194	166	2	of	of	ADP
admet-194	166	3	tau	tau	PROPN
admet-194	166	4	aggregation	aggregation	NOUN
admet-194	166	5	independent	independent	ADJ
admet-194	166	6	of	of	ADP
admet-194	166	7	phosphorylation	phosphorylation	NOUN
admet-194	166	8	have	have	AUX
admet-194	166	9	been	be	AUX
admet-194	166	10	found	find	VERB
admet-194	166	11	and	and	CCONJ
admet-194	166	12	tested	test	VERB
admet-194	166	13	admet	admet	PROPN
admet-194	166	14	&	&	CCONJ
admet-194	166	15	dmpk	dmpk	PROPN
admet-194	166	16	3(3	3(3	NUM
admet-194	166	17	)	)	PUNCT
admet-194	166	18	(	(	PUNCT
admet-194	166	19	2015	2015	NUM
admet-194	166	20	)	)	PUNCT
admet-194	166	21	216	216	NUM
admet-194	166	22	-	-	SYM
admet-194	166	23	234	234	NUM
admet-194	166	24	chemical	chemical	NOUN
admet-194	166	25	and	and	CCONJ
admet-194	166	26	physical	physical	ADJ
admet-194	166	27	approaches	approach	NOUN
admet-194	166	28	for	for	ADP
admet-194	166	29	the	the	DET
admet-194	166	30	treatment	treatment	NOUN
admet-194	166	31	of	of	ADP
admet-194	166	32	ad	ad	NOUN
admet-194	166	33	doi	doi	NOUN
admet-194	166	34	:	:	PUNCT
admet-194	166	35	10.5599	10.5599	NUM
admet-194	166	36	/	/	SYM
admet-194	166	37	admet.3.3.194	admet.3.3.194	PROPN
admet-194	166	38	223	223	NUM
admet-194	166	39	in	in	ADP
admet-194	166	40	cell	cell	NOUN
admet-194	166	41	cultures	culture	NOUN
admet-194	166	42	[	[	X
admet-194	166	43	92	92	NUM
admet-194	166	44	]	]	PUNCT
admet-194	166	45	,	,	PUNCT
admet-194	166	46	including	include	VERB
admet-194	166	47	n	n	CCONJ
admet-194	166	48	-	-	PUNCT
admet-194	166	49	phenylamines	phenylamine	NOUN
admet-194	166	50	,	,	PUNCT
admet-194	166	51	phenothiazines	phenothiazine	NOUN
admet-194	166	52	,	,	PUNCT
admet-194	166	53	thiazolyl	thiazolyl	NOUN
admet-194	166	54	-	-	PUNCT
admet-194	166	55	hydrazides	hydrazide	NOUN
admet-194	166	56	,	,	PUNCT
admet-194	166	57	anthraquinones	anthraquinone	NOUN
admet-194	166	58	,	,	PUNCT
admet-194	166	59	thiacarbocyanine	thiacarbocyanine	NOUN
admet-194	166	60	dyes	dye	NOUN
admet-194	166	61	,	,	PUNCT
admet-194	166	62	polyphenols	polyphenol	NOUN
admet-194	166	63	,	,	PUNCT
admet-194	166	64	aminothienopyridazines	aminothienopyridazine	NOUN
admet-194	166	65	,	,	PUNCT
admet-194	166	66	rhodanines	rhodanine	NOUN
admet-194	166	67	,	,	PUNCT
admet-194	166	68	quinoxalines	quinoxaline	NOUN
admet-194	166	69	and	and	CCONJ
admet-194	166	70	so	so	ADV
admet-194	166	71	on	on	ADP
admet-194	166	72	[	[	PUNCT
admet-194	166	73	93	93	NUM
admet-194	166	74	]	]	PUNCT
admet-194	166	75	.	.	PUNCT
admet-194	167	1	2.1.2.3	2.1.2.3	NUM
admet-194	167	2	prevention	prevention	NOUN
admet-194	167	3	of	of	ADP
admet-194	167	4	tau	tau	PROPN
admet-194	167	5	misfolding	misfolde	VERB
admet-194	167	6	besides	besides	SCONJ
admet-194	167	7	tau	tau	PROPN
admet-194	167	8	aggregation	aggregation	NOUN
admet-194	167	9	,	,	PUNCT
admet-194	167	10	the	the	DET
admet-194	167	11	misfolding	misfolding	NOUN
admet-194	167	12	of	of	ADP
admet-194	167	13	hyperphosphorylated	hyperphosphorylated	ADJ
admet-194	167	14	tau	tau	PROPN
admet-194	167	15	is	be	AUX
admet-194	167	16	conducive	conducive	ADJ
admet-194	167	17	to	to	ADP
admet-194	167	18	the	the	DET
admet-194	167	19	pathology	pathology	NOUN
admet-194	167	20	of	of	ADP
admet-194	167	21	ad	ad	NOUN
admet-194	167	22	.	.	PUNCT
admet-194	168	1	it	it	PRON
admet-194	168	2	has	have	AUX
admet-194	168	3	been	be	AUX
admet-194	168	4	suggested	suggest	VERB
admet-194	168	5	that	that	SCONJ
admet-194	168	6	the	the	DET
admet-194	168	7	misfolding	misfolding	NOUN
admet-194	168	8	of	of	ADP
admet-194	168	9	tau	tau	PROPN
admet-194	168	10	and	and	CCONJ
admet-194	168	11	the	the	DET
admet-194	168	12	development	development	NOUN
admet-194	168	13	of	of	ADP
admet-194	168	14	nfts	nft	NOUN
admet-194	168	15	might	might	AUX
admet-194	168	16	be	be	AUX
admet-194	168	17	prevented	prevent	VERB
admet-194	168	18	by	by	ADP
admet-194	168	19	molecular	molecular	ADJ
admet-194	168	20	chaperones	chaperone	NOUN
admet-194	169	1	[	[	X
admet-194	169	2	94	94	NUM
admet-194	169	3	]	]	PUNCT
admet-194	169	4	.	.	PUNCT
admet-194	170	1	moreover	moreover	ADV
admet-194	170	2	,	,	PUNCT
admet-194	170	3	heat	heat	NOUN
admet-194	170	4	shock	shock	NOUN
admet-194	170	5	proteins	protein	NOUN
admet-194	170	6	could	could	AUX
admet-194	170	7	activate	activate	VERB
admet-194	170	8	chaperones	chaperone	NOUN
admet-194	170	9	to	to	PART
admet-194	170	10	contribute	contribute	VERB
admet-194	170	11	to	to	PART
admet-194	170	12	prevent	prevent	VERB
admet-194	170	13	misfolding	misfolding	NOUN
admet-194	170	14	of	of	ADP
admet-194	170	15	tau	tau	PROPN
admet-194	171	1	[	[	X
admet-194	171	2	95	95	NUM
admet-194	171	3	]	]	PUNCT
admet-194	171	4	.	.	PUNCT
admet-194	172	1	2.1.2.4	2.1.2.4	NUM
admet-194	172	2	anti	anti	ADJ
admet-194	172	3	-	-	ADJ
admet-194	172	4	phospho	phospho	ADJ
admet-194	172	5	tau	tau	PROPN
admet-194	172	6	antibodies	antibodie	VERB
admet-194	172	7	it	it	PRON
admet-194	172	8	would	would	AUX
admet-194	172	9	be	be	AUX
admet-194	172	10	possible	possible	ADJ
admet-194	172	11	to	to	PART
admet-194	172	12	prevent	prevent	VERB
admet-194	172	13	the	the	DET
admet-194	172	14	aggregation	aggregation	NOUN
admet-194	172	15	of	of	ADP
admet-194	172	16	hyperphosphorylated	hyperphosphorylated	ADJ
admet-194	172	17	tau	tau	PROPN
admet-194	172	18	in	in	ADP
admet-194	172	19	order	order	NOUN
admet-194	172	20	to	to	PART
admet-194	172	21	limit	limit	VERB
admet-194	172	22	its	its	PRON
admet-194	172	23	neurotoxic	neurotoxic	ADJ
admet-194	172	24	effect	effect	NOUN
admet-194	172	25	.	.	PUNCT
admet-194	173	1	sigurdsson	sigurdsson	NOUN
admet-194	173	2	and	and	CCONJ
admet-194	173	3	his	his	PRON
admet-194	173	4	colleagues	colleague	NOUN
admet-194	173	5	suggested	suggest	VERB
admet-194	173	6	that	that	SCONJ
admet-194	173	7	anti	anti	ADJ
admet-194	173	8	-	-	ADJ
admet-194	173	9	phospho	phospho	ADJ
admet-194	173	10	tau	tau	PROPN
admet-194	173	11	antibodies	antibodie	VERB
admet-194	173	12	could	could	AUX
admet-194	173	13	inhibit	inhibit	VERB
admet-194	173	14	brain	brain	NOUN
admet-194	173	15	aggregated	aggregate	VERB
admet-194	173	16	tau	tau	PROPN
admet-194	173	17	and	and	CCONJ
admet-194	173	18	suppress	suppress	VERB
admet-194	173	19	progression	progression	NOUN
admet-194	173	20	of	of	ADP
admet-194	173	21	tangle	tangle	NOUN
admet-194	173	22	-	-	PUNCT
admet-194	173	23	related	relate	VERB
admet-194	173	24	behavioural	behavioural	ADJ
admet-194	173	25	phenotype	phenotype	NOUN
admet-194	173	26	in	in	ADP
admet-194	173	27	mouse	mouse	NOUN
admet-194	173	28	models	model	NOUN
admet-194	173	29	[	[	X
admet-194	173	30	96	96	NUM
admet-194	173	31	]	]	PUNCT
admet-194	173	32	.	.	PUNCT
admet-194	174	1	2.1.2.5	2.1.2.5	NUM
admet-194	174	2	compensation	compensation	NOUN
admet-194	174	3	for	for	ADP
admet-194	174	4	tau	tau	PROPN
admet-194	174	5	function	function	NOUN
admet-194	174	6	since	since	SCONJ
admet-194	174	7	hyperphosphorylated	hyperphosphorylate	VERB
admet-194	174	8	tau	tau	PROPN
admet-194	174	9	lose	lose	VERB
admet-194	174	10	the	the	DET
admet-194	174	11	physiological	physiological	ADJ
admet-194	174	12	cellular	cellular	ADJ
admet-194	174	13	function	function	NOUN
admet-194	174	14	of	of	ADP
admet-194	174	15	binding	bind	VERB
admet-194	174	16	and	and	CCONJ
admet-194	174	17	stabilizing	stabilize	VERB
admet-194	174	18	microtubules	microtubule	NOUN
admet-194	174	19	,	,	PUNCT
admet-194	174	20	possessing	possess	VERB
admet-194	174	21	the	the	DET
admet-194	174	22	function	function	NOUN
admet-194	174	23	of	of	ADP
admet-194	174	24	stabilizing	stabilize	VERB
admet-194	174	25	microtubules	microtubule	NOUN
admet-194	174	26	,	,	PUNCT
admet-194	174	27	bms-241027	bms-241027	NOUN
admet-194	174	28	may	may	AUX
admet-194	174	29	compensate	compensate	VERB
admet-194	174	30	for	for	ADP
admet-194	174	31	the	the	DET
admet-194	174	32	loss	loss	NOUN
admet-194	174	33	of	of	ADP
admet-194	174	34	normal	normal	ADJ
admet-194	174	35	tau	tau	NOUN
admet-194	174	36	,	,	PUNCT
admet-194	174	37	and	and	CCONJ
admet-194	174	38	then	then	ADV
admet-194	174	39	suppress	suppress	VERB
admet-194	174	40	neurodegeneration	neurodegeneration	NOUN
admet-194	174	41	and	and	CCONJ
admet-194	174	42	succeeding	succeed	VERB
admet-194	174	43	cognitive	cognitive	ADJ
admet-194	174	44	decline	decline	NOUN
admet-194	174	45	[	[	X
admet-194	174	46	97	97	NUM
admet-194	174	47	]	]	PUNCT
admet-194	174	48	.	.	PUNCT
admet-194	175	1	bms241027	bms241027	PROPN
admet-194	175	2	showed	show	VERB
admet-194	175	3	its	its	PRON
admet-194	175	4	functions	function	NOUN
admet-194	175	5	of	of	ADP
admet-194	175	6	reversing	reverse	VERB
admet-194	175	7	behavioral	behavioral	ADJ
admet-194	175	8	and	and	CCONJ
admet-194	175	9	cognitive	cognitive	ADJ
admet-194	175	10	deficiencies	deficiency	NOUN
admet-194	175	11	and	and	CCONJ
admet-194	175	12	restraining	restrain	VERB
admet-194	175	13	neuron	neuron	NOUN
admet-194	175	14	loss	loss	NOUN
admet-194	175	15	in	in	ADP
admet-194	175	16	mouse	mouse	NOUN
admet-194	175	17	models	model	NOUN
admet-194	175	18	[	[	X
admet-194	175	19	98	98	NUM
admet-194	175	20	,	,	PUNCT
admet-194	175	21	99	99	NUM
admet-194	175	22	]	]	PUNCT
admet-194	175	23	.	.	PUNCT
admet-194	176	1	a	a	DET
admet-194	176	2	phase	phase	NOUN
admet-194	176	3	1	1	NUM
admet-194	176	4	trial	trial	NOUN
admet-194	176	5	to	to	PART
admet-194	176	6	evaluate	evaluate	VERB
admet-194	176	7	the	the	DET
admet-194	176	8	tolerability	tolerability	NOUN
admet-194	176	9	and	and	CCONJ
admet-194	176	10	pharmacology	pharmacology	NOUN
admet-194	176	11	of	of	ADP
admet-194	176	12	bms-241027	bms-241027	NOUN
admet-194	176	13	was	be	AUX
admet-194	176	14	completed	complete	VERB
admet-194	176	15	in	in	ADP
admet-194	176	16	2013	2013	NUM
admet-194	176	17	,	,	PUNCT
admet-194	176	18	but	but	CCONJ
admet-194	176	19	no	no	DET
admet-194	176	20	consequences	consequence	NOUN
admet-194	176	21	have	have	AUX
admet-194	176	22	been	be	AUX
admet-194	176	23	demonstrated	demonstrate	VERB
admet-194	176	24	[	[	X
admet-194	176	25	100	100	NUM
admet-194	176	26	]	]	PUNCT
admet-194	176	27	.	.	PUNCT
admet-194	177	1	2.2	2.2	NUM
admet-194	177	2	symptomatic	symptomatic	ADJ
admet-194	177	3	therapies	therapy	NOUN
admet-194	177	4	:	:	PUNCT
admet-194	177	5	approved	approve	VERB
admet-194	177	6	drugs	drug	NOUN
admet-194	177	7	for	for	ADP
admet-194	177	8	treatment	treatment	NOUN
admet-194	177	9	in	in	ADP
admet-194	177	10	alzheimer	alzheimer	PROPN
admet-194	177	11	’s	’s	PART
admet-194	177	12	disease	disease	NOUN
admet-194	177	13	until	until	ADP
admet-194	177	14	now	now	ADV
admet-194	177	15	,	,	PUNCT
admet-194	177	16	though	though	SCONJ
admet-194	177	17	there	there	PRON
admet-194	177	18	are	be	VERB
admet-194	177	19	no	no	DET
admet-194	177	20	available	available	ADJ
admet-194	177	21	drugs	drug	NOUN
admet-194	177	22	which	which	PRON
admet-194	177	23	can	can	AUX
admet-194	177	24	cure	cure	VERB
admet-194	177	25	ad	ad	NOUN
admet-194	177	26	,	,	PUNCT
admet-194	177	27	some	some	DET
admet-194	177	28	drugs	drug	NOUN
admet-194	177	29	have	have	VERB
admet-194	177	30	the	the	DET
admet-194	177	31	ability	ability	NOUN
admet-194	177	32	to	to	PART
admet-194	177	33	improve	improve	VERB
admet-194	177	34	symptoms	symptom	NOUN
admet-194	177	35	,	,	PUNCT
admet-194	177	36	or	or	CCONJ
admet-194	177	37	slow	slow	VERB
admet-194	177	38	down	down	ADP
admet-194	177	39	their	their	PRON
admet-194	177	40	progression	progression	NOUN
admet-194	177	41	in	in	ADP
admet-194	177	42	some	some	DET
admet-194	177	43	patients	patient	NOUN
admet-194	177	44	.	.	PUNCT
admet-194	178	1	current	current	ADJ
admet-194	178	2	drugs	drug	NOUN
admet-194	178	3	for	for	ADP
admet-194	178	4	treating	treat	VERB
admet-194	178	5	ad	ad	NOUN
admet-194	178	6	have	have	AUX
admet-194	178	7	been	be	AUX
admet-194	178	8	categorized	categorize	VERB
admet-194	178	9	into	into	ADP
admet-194	178	10	two	two	NUM
admet-194	178	11	types	type	NOUN
admet-194	178	12	:	:	PUNCT
admet-194	178	13	one	one	NUM
admet-194	178	14	is	be	AUX
admet-194	178	15	inhibitors	inhibitor	NOUN
admet-194	178	16	of	of	ADP
admet-194	178	17	the	the	DET
admet-194	178	18	acetylcholinesterase	acetylcholinesterase	NOUN
admet-194	178	19	(	(	PUNCT
admet-194	178	20	acheis	acheis	PROPN
admet-194	178	21	)	)	PUNCT
admet-194	178	22	,	,	PUNCT
admet-194	178	23	and	and	CCONJ
admet-194	178	24	the	the	DET
admet-194	178	25	other	other	ADJ
admet-194	178	26	one	one	NOUN
admet-194	178	27	is	be	AUX
admet-194	178	28	n	n	CCONJ
admet-194	178	29	-	-	PUNCT
admet-194	178	30	methyl	methyl	NOUN
admet-194	178	31	-	-	PUNCT
admet-194	178	32	d	d	NOUN
admet-194	178	33	-	-	NOUN
admet-194	178	34	aspartate	aspartate	ADJ
admet-194	178	35	(	(	PUNCT
admet-194	178	36	nmda	nmda	ADJ
admet-194	178	37	)	)	PUNCT
admet-194	178	38	receptor	receptor	NOUN
admet-194	178	39	antagonists	antagonist	NOUN
admet-194	178	40	,	,	PUNCT
admet-194	178	41	which	which	PRON
admet-194	178	42	target	target	VERB
admet-194	178	43	glutamatergic	glutamatergic	ADJ
admet-194	178	44	and	and	CCONJ
admet-194	178	45	cholinergic	cholinergic	ADJ
admet-194	178	46	neurotransmission	neurotransmission	NOUN
admet-194	178	47	to	to	PART
admet-194	178	48	improve	improve	VERB
admet-194	178	49	the	the	DET
admet-194	178	50	symptoms	symptom	NOUN
admet-194	178	51	[	[	X
admet-194	178	52	13	13	NUM
admet-194	178	53	]	]	PUNCT
admet-194	178	54	,	,	PUNCT
admet-194	178	55	though	though	SCONJ
admet-194	178	56	their	their	PRON
admet-194	178	57	neuroprotective	neuroprotective	ADJ
admet-194	178	58	activity	activity	NOUN
admet-194	178	59	nowadays	nowadays	ADV
admet-194	178	60	is	be	AUX
admet-194	178	61	still	still	ADV
admet-194	178	62	controversial	controversial	ADJ
admet-194	178	63	.	.	PUNCT
admet-194	179	1	as	as	SCONJ
admet-194	179	2	acheis	acheis	NOUN
admet-194	179	3	can	can	AUX
admet-194	179	4	increase	increase	VERB
admet-194	179	5	the	the	DET
admet-194	179	6	levels	level	NOUN
admet-194	179	7	of	of	ADP
admet-194	179	8	acetylcholine	acetylcholine	NOUN
admet-194	179	9	,	,	PUNCT
admet-194	179	10	a	a	DET
admet-194	179	11	key	key	ADJ
admet-194	179	12	neurotransmitter	neurotransmitter	NOUN
admet-194	179	13	involved	involve	VERB
admet-194	179	14	in	in	ADP
admet-194	179	15	memory	memory	NOUN
admet-194	179	16	,	,	PUNCT
admet-194	179	17	they	they	PRON
admet-194	179	18	are	be	AUX
admet-194	179	19	now	now	ADV
admet-194	179	20	utilized	utilize	VERB
admet-194	179	21	as	as	ADP
admet-194	179	22	long	long	ADJ
admet-194	179	23	-	-	PUNCT
admet-194	179	24	term	term	NOUN
admet-194	179	25	symptomatic	symptomatic	ADJ
admet-194	179	26	treatments	treatment	NOUN
admet-194	179	27	for	for	ADP
admet-194	179	28	ad	ad	NOUN
admet-194	179	29	patients	patient	NOUN
admet-194	179	30	[	[	X
admet-194	179	31	101	101	NUM
admet-194	179	32	]	]	PUNCT
admet-194	179	33	.	.	PUNCT
admet-194	180	1	ad	ad	NOUN
admet-194	180	2	damages	damage	NOUN
admet-194	180	3	or	or	CCONJ
admet-194	180	4	destroys	destroy	VERB
admet-194	180	5	neurons	neuron	NOUN
admet-194	180	6	which	which	PRON
admet-194	180	7	produce	produce	VERB
admet-194	180	8	and	and	CCONJ
admet-194	180	9	use	use	VERB
admet-194	180	10	acetylcholine	acetylcholine	NOUN
admet-194	180	11	(	(	PUNCT
admet-194	180	12	ach	ach	PROPN
admet-194	180	13	)	)	PUNCT
admet-194	180	14	,	,	PUNCT
admet-194	180	15	then	then	ADV
admet-194	180	16	reducing	reduce	VERB
admet-194	180	17	the	the	DET
admet-194	180	18	amount	amount	NOUN
admet-194	180	19	available	available	ADJ
admet-194	180	20	to	to	PART
admet-194	180	21	carry	carry	VERB
admet-194	180	22	messages	message	NOUN
admet-194	180	23	.	.	PUNCT
admet-194	181	1	an	an	DET
admet-194	181	2	achei	achei	PROPN
admet-194	181	3	slows	slow	VERB
admet-194	181	4	the	the	DET
admet-194	181	5	breakdown	breakdown	NOUN
admet-194	181	6	of	of	ADP
admet-194	181	7	ach	ach	NOUN
admet-194	181	8	by	by	ADP
admet-194	181	9	blocking	block	VERB
admet-194	181	10	the	the	DET
admet-194	181	11	activity	activity	NOUN
admet-194	181	12	of	of	ADP
admet-194	181	13	ache	ache	ADV
admet-194	181	14	.	.	PUNCT
admet-194	182	1	by	by	ADP
admet-194	182	2	maintaining	maintain	VERB
admet-194	182	3	ach	ach	NOUN
admet-194	182	4	levels	level	NOUN
admet-194	182	5	,	,	PUNCT
admet-194	182	6	the	the	DET
admet-194	182	7	drug	drug	NOUN
admet-194	182	8	may	may	AUX
admet-194	182	9	help	help	VERB
admet-194	182	10	compensate	compensate	VERB
admet-194	182	11	for	for	ADP
admet-194	182	12	the	the	DET
admet-194	182	13	loss	loss	NOUN
admet-194	182	14	of	of	ADP
admet-194	182	15	functioning	function	VERB
admet-194	182	16	neurons	neuron	NOUN
admet-194	182	17	.	.	PUNCT
admet-194	183	1	it	it	PRON
admet-194	183	2	has	have	AUX
admet-194	183	3	also	also	ADV
admet-194	183	4	been	be	AUX
admet-194	183	5	shown	show	VERB
admet-194	183	6	that	that	SCONJ
admet-194	183	7	acheis	acheis	NOUN
admet-194	183	8	intervene	intervene	VERB
admet-194	183	9	with	with	ADP
admet-194	183	10	app	app	NOUN
admet-194	183	11	cleavage	cleavage	NOUN
admet-194	183	12	and	and	CCONJ
admet-194	183	13	decrease	decrease	VERB
admet-194	183	14	aβ	aβ	NOUN
admet-194	183	15	-	-	PUNCT
admet-194	183	16	induced	induce	VERB
admet-194	183	17	toxicity	toxicity	NOUN
admet-194	183	18	through	through	ADP
admet-194	183	19	some	some	DET
admet-194	183	20	mechanisms	mechanism	NOUN
admet-194	183	21	,	,	PUNCT
admet-194	183	22	including	include	VERB
admet-194	183	23	interference	interference	NOUN
admet-194	183	24	of	of	ADP
admet-194	183	25	the	the	DET
admet-194	183	26	aβ	aβ	NOUN
admet-194	183	27	production	production	NOUN
admet-194	183	28	,	,	PUNCT
admet-194	183	29	alteration	alteration	NOUN
admet-194	183	30	of	of	ADP
admet-194	183	31	the	the	DET
admet-194	183	32	aβ	aβ	NOUN
admet-194	183	33	levels	level	NOUN
admet-194	183	34	,	,	PUNCT
admet-194	183	35	and	and	CCONJ
admet-194	183	36	formation	formation	NOUN
admet-194	183	37	of	of	ADP
admet-194	183	38	the	the	DET
admet-194	183	39	soluble	soluble	ADJ
admet-194	183	40	form	form	NOUN
admet-194	183	41	of	of	ADP
admet-194	183	42	app	app	NOUN
admet-194	184	1	[	[	X
admet-194	184	2	101	101	NUM
admet-194	184	3	]	]	PUNCT
admet-194	184	4	.	.	PUNCT
admet-194	185	1	acheis	acheis	PROPN
admet-194	185	2	can	can	AUX
admet-194	185	3	also	also	ADV
admet-194	185	4	modulate	modulate	VERB
admet-194	185	5	the	the	DET
admet-194	185	6	expression	expression	NOUN
admet-194	185	7	of	of	ADP
admet-194	185	8	ache	ache	NOUN
admet-194	185	9	isoforms	isoform	NOUN
admet-194	185	10	;	;	PUNCT
admet-194	185	11	increase	increase	VERB
admet-194	185	12	the	the	DET
admet-194	185	13	expression	expression	NOUN
admet-194	185	14	of	of	ADP
admet-194	185	15	nicotinic	nicotinic	ADJ
admet-194	185	16	receptors	receptor	NOUN
admet-194	185	17	,	,	PUNCT
admet-194	185	18	via	via	ADP
admet-194	185	19	which	which	DET
admet-194	185	20	nicotine	nicotine	NOUN
admet-194	185	21	can	can	AUX
admet-194	185	22	show	show	VERB
admet-194	185	23	its	its	PRON
admet-194	185	24	protective	protective	ADJ
admet-194	185	25	effect	effect	NOUN
admet-194	185	26	by	by	ADP
admet-194	185	27	suppress	suppress	VERB
admet-194	185	28	aβ	aβ	NOUN
admet-194	185	29	toxicity	toxicity	NOUN
admet-194	185	30	and	and	CCONJ
admet-194	185	31	aβ	aβ	NOUN
admet-194	186	1	[	[	X
admet-194	186	2	102	102	NUM
admet-194	186	3	]	]	PUNCT
admet-194	186	4	.	.	PUNCT
admet-194	187	1	although	although	SCONJ
admet-194	187	2	modest	modest	ADJ
admet-194	187	3	,	,	PUNCT
admet-194	187	4	acheis	acheis	NOUN
admet-194	187	5	still	still	ADV
admet-194	187	6	exhibit	exhibit	VERB
admet-194	187	7	a	a	DET
admet-194	187	8	significant	significant	ADJ
admet-194	187	9	effect	effect	NOUN
admet-194	187	10	on	on	ADP
admet-194	187	11	the	the	DET
admet-194	187	12	cognitive	cognitive	ADJ
admet-194	187	13	functions	function	NOUN
admet-194	187	14	of	of	ADP
admet-194	187	15	ad	ad	NOUN
admet-194	187	16	patients	patient	NOUN
admet-194	187	17	,	,	PUNCT
admet-194	187	18	and	and	CCONJ
admet-194	187	19	also	also	ADV
admet-194	187	20	show	show	VERB
admet-194	187	21	a	a	DET
admet-194	187	22	positive	positive	ADJ
admet-194	187	23	effect	effect	NOUN
admet-194	187	24	on	on	ADP
admet-194	187	25	behavior	behavior	NOUN
admet-194	187	26	and	and	CCONJ
admet-194	187	27	mood	mood	NOUN
admet-194	187	28	[	[	X
admet-194	187	29	103	103	NUM
admet-194	187	30	]	]	PUNCT
admet-194	187	31	.	.	PUNCT
admet-194	188	1	in	in	ADP
admet-194	188	2	general	general	ADJ
admet-194	188	3	,	,	PUNCT
admet-194	188	4	acheis	achei	NOUN
admet-194	188	5	are	be	AUX
admet-194	188	6	well	well	ADV
admet-194	188	7	tolerated	tolerate	VERB
admet-194	188	8	,	,	PUNCT
admet-194	188	9	but	but	CCONJ
admet-194	188	10	the	the	DET
admet-194	188	11	possibility	possibility	NOUN
admet-194	188	12	of	of	ADP
admet-194	188	13	adverse	adverse	ADJ
admet-194	188	14	effects	effect	NOUN
admet-194	188	15	still	still	ADV
admet-194	188	16	exists	exist	VERB
admet-194	188	17	.	.	PUNCT
admet-194	189	1	different	different	ADJ
admet-194	189	2	acheis	acheis	NOUN
admet-194	189	3	may	may	AUX
admet-194	189	4	have	have	VERB
admet-194	189	5	different	different	ADJ
admet-194	189	6	safety	safety	NOUN
admet-194	189	7	profiles	profile	NOUN
admet-194	189	8	[	[	X
admet-194	189	9	104	104	NUM
admet-194	189	10	]	]	PUNCT
admet-194	189	11	.	.	PUNCT
admet-194	190	1	it	it	PRON
admet-194	190	2	is	be	AUX
admet-194	190	3	believed	believe	VERB
admet-194	190	4	that	that	SCONJ
admet-194	190	5	the	the	DET
admet-194	190	6	benefits	benefit	NOUN
admet-194	190	7	of	of	ADP
admet-194	190	8	the	the	DET
admet-194	190	9	usage	usage	NOUN
admet-194	190	10	of	of	ADP
admet-194	190	11	acheis	acheis	NOUN
admet-194	190	12	outweigh	outweigh	VERB
admet-194	190	13	their	their	PRON
admet-194	190	14	risks	risk	NOUN
admet-194	190	15	and	and	CCONJ
admet-194	190	16	costs	cost	NOUN
admet-194	190	17	.	.	PUNCT
admet-194	191	1	acheis	acheis	PROPN
admet-194	191	2	now	now	ADV
admet-194	191	3	are	be	AUX
admet-194	191	4	considered	consider	VERB
admet-194	191	5	as	as	ADP
admet-194	191	6	primary	primary	ADJ
admet-194	191	7	therapy	therapy	NOUN
admet-194	191	8	for	for	ADP
admet-194	191	9	the	the	DET
admet-194	191	10	patients	patient	NOUN
admet-194	191	11	with	with	ADP
admet-194	191	12	mild	mild	ADJ
admet-194	191	13	to	to	AUX
admet-194	191	14	moderate	moderate	ADJ
admet-194	191	15	ad	ad	NOUN
admet-194	191	16	[	[	X
admet-194	191	17	12	12	NUM
admet-194	191	18	]	]	PUNCT
admet-194	191	19	.	.	PUNCT
admet-194	192	1	four	four	NUM
admet-194	192	2	different	different	ADJ
admet-194	192	3	acheis	acheis	NOUN
admet-194	192	4	drugs	drug	NOUN
admet-194	192	5	have	have	AUX
admet-194	192	6	been	be	AUX
admet-194	192	7	approved	approve	VERB
admet-194	192	8	by	by	ADP
admet-194	192	9	u.s	u.s	PROPN
admet-194	192	10	.	.	PROPN
admet-194	192	11	fda	fda	PROPN
admet-194	192	12	to	to	PART
admet-194	192	13	treat	treat	VERB
admet-194	192	14	ad	ad	NOUN
admet-194	192	15	symptoms	symptom	NOUN
admet-194	192	16	,	,	PUNCT
admet-194	192	17	which	which	PRON
admet-194	192	18	are	be	AUX
admet-194	192	19	jing	je	VERB
admet-194	192	20	li	li	PROPN
admet-194	192	21	et	et	PROPN
admet-194	192	22	al	al	PROPN
admet-194	192	23	.	.	PROPN
admet-194	192	24	admet	admet	PROPN
admet-194	192	25	&	&	CCONJ
admet-194	192	26	dmpk	dmpk	PROPN
admet-194	192	27	3(3	3(3	NUM
admet-194	192	28	)	)	PUNCT
admet-194	192	29	(	(	PUNCT
admet-194	192	30	2015	2015	NUM
admet-194	192	31	)	)	PUNCT
admet-194	192	32	216	216	NUM
admet-194	192	33	-	-	SYM
admet-194	192	34	234	234	NUM
admet-194	192	35	224	224	NUM
admet-194	192	36	donepezil	donepezil	NOUN
admet-194	192	37	,	,	PUNCT
admet-194	192	38	rivastigmine	rivastigmine	NOUN
admet-194	192	39	,	,	PUNCT
admet-194	192	40	galantamine	galantamine	NOUN
admet-194	192	41	and	and	CCONJ
admet-194	192	42	tacrine	tacrine	NOUN
admet-194	192	43	.	.	PUNCT
admet-194	193	1	donepezil	donepezil	PROPN
admet-194	193	2	is	be	AUX
admet-194	193	3	approved	approve	VERB
admet-194	193	4	to	to	PART
admet-194	193	5	treat	treat	VERB
admet-194	193	6	all	all	DET
admet-194	193	7	stages	stage	NOUN
admet-194	193	8	of	of	ADP
admet-194	193	9	ad	ad	NOUN
admet-194	194	1	[	[	X
admet-194	194	2	101,105,106	101,105,106	NUM
admet-194	194	3	]	]	X
admet-194	194	4	;	;	PUNCT
admet-194	194	5	rivastigmine	rivastigmine	NOUN
admet-194	194	6	and	and	CCONJ
admet-194	194	7	galantamine	galantamine	NOUN
admet-194	194	8	are	be	AUX
admet-194	194	9	approved	approve	VERB
admet-194	194	10	to	to	PART
admet-194	194	11	treat	treat	VERB
admet-194	194	12	mild	mild	ADJ
admet-194	194	13	to	to	ADP
admet-194	194	14	moderate	moderate	ADJ
admet-194	194	15	stages	stage	NOUN
admet-194	194	16	[	[	X
admet-194	194	17	101	101	NUM
admet-194	194	18	]	]	PUNCT
admet-194	194	19	.	.	PUNCT
admet-194	195	1	although	although	SCONJ
admet-194	195	2	tacrine	tacrine	NOUN
admet-194	195	3	is	be	AUX
admet-194	195	4	the	the	DET
admet-194	195	5	first	first	ADJ
admet-194	195	6	achei	achei	PROPN
admet-194	195	7	which	which	PRON
admet-194	195	8	was	be	AUX
admet-194	195	9	approved	approve	VERB
admet-194	195	10	by	by	ADP
admet-194	195	11	the	the	DET
admet-194	195	12	fda	fda	PROPN
admet-194	195	13	in	in	ADP
admet-194	195	14	1993	1993	NUM
admet-194	195	15	,	,	PUNCT
admet-194	195	16	some	some	DET
admet-194	195	17	side	side	NOUN
admet-194	195	18	effects	effect	NOUN
admet-194	195	19	including	include	VERB
admet-194	195	20	hepatotoxic	hepatotoxic	ADJ
admet-194	195	21	effects	effect	NOUN
admet-194	195	22	[	[	X
admet-194	195	23	107	107	NUM
admet-194	195	24	]	]	PUNCT
admet-194	195	25	lead	lead	NOUN
admet-194	195	26	to	to	ADP
admet-194	195	27	its	its	PRON
admet-194	195	28	rare	rare	ADJ
admet-194	195	29	usage	usage	NOUN
admet-194	195	30	.	.	PUNCT
admet-194	196	1	the	the	DET
admet-194	196	2	fifth	fifth	PROPN
admet-194	196	3	alzheimer	alzheimer	PROPN
admet-194	196	4	's	's	PART
admet-194	196	5	drug	drug	NOUN
admet-194	196	6	,	,	PUNCT
admet-194	196	7	memantine	memantine	NOUN
admet-194	196	8	,	,	PUNCT
admet-194	196	9	is	be	AUX
admet-194	196	10	an	an	DET
admet-194	196	11	nmda	nmda	ADJ
admet-194	196	12	receptor	receptor	NOUN
admet-194	196	13	antagonist	antagonist	NOUN
admet-194	196	14	,	,	PUNCT
admet-194	196	15	which	which	PRON
admet-194	196	16	has	have	VERB
admet-194	196	17	the	the	DET
admet-194	196	18	capability	capability	NOUN
admet-194	196	19	of	of	ADP
admet-194	196	20	suppressing	suppress	VERB
admet-194	196	21	aβ	aβ	NOUN
admet-194	196	22	toxicity	toxicity	NOUN
admet-194	196	23	and	and	CCONJ
admet-194	196	24	microglia	microglia	ADV
admet-194	196	25	-	-	PUNCT
admet-194	196	26	associated	associated	ADJ
admet-194	196	27	inflammation	inflammation	NOUN
admet-194	196	28	;	;	PUNCT
admet-194	196	29	preventing	prevent	VERB
admet-194	196	30	hyperphosphorylation	hyperphosphorylation	NOUN
admet-194	196	31	of	of	ADP
admet-194	196	32	tau	tau	PROPN
admet-194	196	33	;	;	PUNCT
admet-194	196	34	increasing	increase	VERB
admet-194	196	35	the	the	DET
admet-194	196	36	release	release	NOUN
admet-194	196	37	of	of	ADP
admet-194	196	38	neurotrophic	neurotrophic	ADJ
admet-194	196	39	factors	factor	NOUN
admet-194	196	40	from	from	ADP
admet-194	196	41	astroglia	astroglia	PROPN
admet-194	196	42	[	[	X
admet-194	196	43	108	108	NUM
admet-194	196	44	-	-	SYM
admet-194	196	45	110	110	NUM
admet-194	196	46	]	]	PUNCT
admet-194	196	47	.	.	PUNCT
admet-194	197	1	memantine	memantine	NOUN
admet-194	197	2	works	work	NOUN
admet-194	197	3	via	via	ADP
admet-194	197	4	decreasing	decrease	VERB
admet-194	197	5	glutamate	glutamate	ADJ
admet-194	197	6	excitotoxicity	excitotoxicity	NOUN
admet-194	197	7	.	.	PUNCT
admet-194	198	1	glutamate	glutamate	VERB
admet-194	198	2	itself	itself	PRON
admet-194	198	3	is	be	AUX
admet-194	198	4	a	a	DET
admet-194	198	5	vital	vital	ADJ
admet-194	198	6	neurotransmitter	neurotransmitter	NOUN
admet-194	198	7	which	which	PRON
admet-194	198	8	involved	involve	VERB
admet-194	198	9	in	in	ADP
admet-194	198	10	learning	learning	NOUN
admet-194	198	11	and	and	CCONJ
admet-194	198	12	memory	memory	NOUN
admet-194	198	13	in	in	ADP
admet-194	198	14	the	the	DET
admet-194	198	15	brain	brain	NOUN
admet-194	199	1	[	[	X
admet-194	199	2	111	111	NUM
admet-194	199	3	]	]	PUNCT
admet-194	199	4	.	.	PUNCT
admet-194	200	1	nmda	nmda	ADJ
admet-194	200	2	receptors	receptor	NOUN
admet-194	200	3	permit	permit	VERB
admet-194	200	4	calcium	calcium	NOUN
admet-194	200	5	to	to	PART
admet-194	200	6	enter	enter	VERB
admet-194	200	7	the	the	DET
admet-194	200	8	cell	cell	NOUN
admet-194	200	9	when	when	SCONJ
admet-194	200	10	combining	combine	VERB
admet-194	200	11	with	with	ADP
admet-194	200	12	glutamate	glutamate	NOUN
admet-194	200	13	,	,	PUNCT
admet-194	200	14	which	which	PRON
admet-194	200	15	is	be	AUX
admet-194	200	16	imperative	imperative	ADJ
admet-194	200	17	for	for	ADP
admet-194	200	18	cell	cell	NOUN
admet-194	200	19	signaling	signal	VERB
admet-194	200	20	,	,	PUNCT
admet-194	200	21	and	and	CCONJ
admet-194	200	22	then	then	ADV
admet-194	200	23	for	for	ADP
admet-194	200	24	learning	learning	NOUN
admet-194	200	25	and	and	CCONJ
admet-194	200	26	memory	memory	NOUN
admet-194	200	27	[	[	X
admet-194	200	28	112	112	NUM
admet-194	200	29	]	]	PUNCT
admet-194	200	30	.	.	PUNCT
admet-194	201	1	however	however	ADV
admet-194	201	2	,	,	PUNCT
admet-194	201	3	excess	excess	ADJ
admet-194	201	4	glutamate	glutamate	NOUN
admet-194	201	5	can	can	AUX
admet-194	201	6	be	be	AUX
admet-194	201	7	released	release	VERB
admet-194	201	8	from	from	ADP
admet-194	201	9	impaired	impaired	ADJ
admet-194	201	10	neurons	neuron	NOUN
admet-194	201	11	in	in	ADP
admet-194	201	12	ad	ad	NOUN
admet-194	201	13	,	,	PUNCT
admet-194	201	14	resulting	result	VERB
admet-194	201	15	in	in	ADP
admet-194	201	16	chronic	chronic	ADJ
admet-194	201	17	overexposure	overexposure	NOUN
admet-194	201	18	to	to	ADP
admet-194	201	19	calcium	calcium	NOUN
admet-194	201	20	,	,	PUNCT
admet-194	201	21	which	which	PRON
admet-194	201	22	can	can	AUX
admet-194	201	23	in	in	ADP
admet-194	201	24	turn	turn	NOUN
admet-194	201	25	accelerate	accelerate	VERB
admet-194	201	26	neuron	neuron	NOUN
admet-194	201	27	impairment	impairment	NOUN
admet-194	202	1	[	[	X
admet-194	202	2	113	113	NUM
admet-194	202	3	]	]	SYM
admet-194	202	4	.	.	PUNCT
admet-194	203	1	memantine	memantine	PROPN
admet-194	203	2	can	can	AUX
admet-194	203	3	partially	partially	ADV
admet-194	203	4	block	block	VERB
admet-194	203	5	the	the	DET
admet-194	203	6	nmda	nmda	ADJ
admet-194	203	7	receptors	receptor	NOUN
admet-194	203	8	,	,	PUNCT
admet-194	203	9	and	and	CCONJ
admet-194	203	10	then	then	ADV
admet-194	203	11	prevent	prevent	VERB
admet-194	203	12	this	this	DET
admet-194	203	13	destructive	destructive	ADJ
admet-194	203	14	chain	chain	NOUN
admet-194	203	15	of	of	ADP
admet-194	203	16	events	event	NOUN
admet-194	203	17	[	[	X
admet-194	203	18	108	108	NUM
admet-194	203	19	,	,	PUNCT
admet-194	203	20	109	109	NUM
admet-194	203	21	]	]	PUNCT
admet-194	203	22	.	.	PUNCT
admet-194	204	1	3	3	X
admet-194	204	2	.	.	X
admet-194	204	3	physical	physical	ADJ
admet-194	204	4	methods	method	NOUN
admet-194	204	5	to	to	PART
admet-194	204	6	treat	treat	VERB
admet-194	204	7	ad	ad	NOUN
admet-194	204	8	3.1	3.1	NUM
admet-194	204	9	clinical	clinical	ADJ
admet-194	204	10	studies	study	NOUN
admet-194	204	11	of	of	ADP
admet-194	204	12	deep	deep	ADJ
admet-194	204	13	brain	brain	NOUN
admet-194	204	14	stimulation	stimulation	NOUN
admet-194	204	15	although	although	SCONJ
admet-194	204	16	dbs	dbs	NOUN
admet-194	204	17	has	have	AUX
admet-194	204	18	been	be	AUX
admet-194	204	19	approved	approve	VERB
admet-194	204	20	to	to	PART
admet-194	204	21	treat	treat	VERB
admet-194	204	22	some	some	DET
admet-194	204	23	progressive	progressive	ADJ
admet-194	204	24	neurodegenerative	neurodegenerative	ADJ
admet-194	204	25	illness	illness	NOUN
admet-194	204	26	,	,	PUNCT
admet-194	204	27	such	such	ADJ
admet-194	204	28	as	as	ADP
admet-194	204	29	parkinson	parkinson	NOUN
admet-194	204	30	disease	disease	NOUN
admet-194	204	31	(	(	PUNCT
admet-194	204	32	pd	pd	PROPN
admet-194	204	33	)	)	PUNCT
admet-194	204	34	,	,	PUNCT
admet-194	204	35	the	the	DET
admet-194	204	36	quantity	quantity	NOUN
admet-194	204	37	of	of	ADP
admet-194	204	38	researches	research	NOUN
admet-194	204	39	concentrating	concentrate	VERB
admet-194	204	40	on	on	ADP
admet-194	204	41	the	the	DET
admet-194	204	42	potential	potential	ADJ
admet-194	204	43	therapeutic	therapeutic	ADJ
admet-194	204	44	effect	effect	NOUN
admet-194	204	45	of	of	ADP
admet-194	204	46	clinical	clinical	ADJ
admet-194	204	47	dbs	dbs	NOUN
admet-194	204	48	on	on	ADP
admet-194	204	49	the	the	DET
admet-194	204	50	dementia	dementia	NOUN
admet-194	204	51	has	have	AUX
admet-194	204	52	been	be	AUX
admet-194	204	53	still	still	ADV
admet-194	204	54	quite	quite	ADV
admet-194	204	55	limited	limited	ADJ
admet-194	204	56	till	till	SCONJ
admet-194	204	57	now	now	ADV
admet-194	204	58	.	.	PUNCT
admet-194	205	1	in	in	ADP
admet-194	205	2	brief	brief	NOUN
admet-194	205	3	,	,	PUNCT
admet-194	205	4	the	the	DET
admet-194	205	5	dbs	dbs	NOUN
admet-194	205	6	technique	technique	NOUN
admet-194	205	7	involves	involve	VERB
admet-194	205	8	stereotactically	stereotactically	ADV
admet-194	205	9	guided	guide	VERB
admet-194	205	10	implantation	implantation	NOUN
admet-194	205	11	of	of	ADP
admet-194	205	12	one	one	NUM
admet-194	205	13	or	or	CCONJ
admet-194	205	14	more	more	ADJ
admet-194	205	15	electrodes	electrode	NOUN
admet-194	205	16	into	into	ADP
admet-194	205	17	targeted	targeted	ADJ
admet-194	205	18	brain	brain	NOUN
admet-194	205	19	region	region	NOUN
admet-194	205	20	,	,	PUNCT
admet-194	205	21	and	and	CCONJ
admet-194	205	22	the	the	DET
admet-194	205	23	electric	electric	ADJ
admet-194	205	24	pulses	pulse	NOUN
admet-194	205	25	which	which	PRON
admet-194	205	26	are	be	AUX
admet-194	205	27	generated	generate	VERB
admet-194	205	28	by	by	ADP
admet-194	205	29	a	a	DET
admet-194	205	30	pacemaker	pacemaker	NOUN
admet-194	205	31	implanted	implant	VERB
admet-194	205	32	in	in	ADP
admet-194	205	33	infraclavicular	infraclavicular	ADJ
admet-194	205	34	area	area	NOUN
admet-194	205	35	will	will	AUX
admet-194	205	36	be	be	AUX
admet-194	205	37	sent	send	VERB
admet-194	205	38	through	through	ADP
admet-194	205	39	wires	wire	NOUN
admet-194	205	40	and	and	CCONJ
admet-194	205	41	then	then	ADV
admet-194	205	42	electrode	electrode	VERB
admet-194	205	43	into	into	ADP
admet-194	205	44	brain	brain	NOUN
admet-194	205	45	to	to	AUX
admet-194	205	46	influence	influence	VERB
admet-194	205	47	neural	neural	ADJ
admet-194	205	48	activities	activity	NOUN
admet-194	205	49	[	[	X
admet-194	205	50	114,115	114,115	NUM
admet-194	205	51	]	]	PUNCT
admet-194	205	52	(	(	PUNCT
admet-194	205	53	see	see	VERB
admet-194	205	54	figure	figure	NOUN
admet-194	205	55	2	2	NUM
admet-194	205	56	)	)	PUNCT
admet-194	205	57	.	.	PUNCT
admet-194	206	1	figure	figure	VERB
admet-194	206	2	2.diagrammatic	2.diagrammatic	NUM
admet-194	206	3	sketch	sketch	NOUN
admet-194	206	4	of	of	ADP
admet-194	206	5	deep	deep	ADJ
admet-194	206	6	brain	brain	NOUN
admet-194	206	7	stimulation	stimulation	NOUN
admet-194	206	8	.	.	PUNCT
admet-194	207	1	dbs	dbs	PROPN
admet-194	207	2	is	be	AUX
admet-194	207	3	a	a	DET
admet-194	207	4	fairly	fairly	ADV
admet-194	207	5	minimally	minimally	ADV
admet-194	207	6	invasive	invasive	ADJ
admet-194	207	7	neurological	neurological	ADJ
admet-194	207	8	procedure	procedure	NOUN
admet-194	207	9	which	which	PRON
admet-194	207	10	involves	involve	VERB
admet-194	207	11	the	the	DET
admet-194	207	12	implantation	implantation	NOUN
admet-194	207	13	of	of	ADP
admet-194	207	14	a	a	DET
admet-194	207	15	brain	brain	NOUN
admet-194	207	16	pacemaker	pacemaker	NOUN
admet-194	207	17	sending	send	VERB
admet-194	207	18	mild	mild	ADJ
admet-194	207	19	electrical	electrical	ADJ
admet-194	207	20	impulses	impulse	NOUN
admet-194	207	21	to	to	ADP
admet-194	207	22	targeted	target	VERB
admet-194	207	23	encephalic	encephalic	ADJ
admet-194	207	24	regions	region	NOUN
admet-194	207	25	to	to	PART
admet-194	207	26	treat	treat	VERB
admet-194	207	27	certain	certain	ADJ
admet-194	207	28	affective	affective	NOUN
admet-194	207	29	and	and	CCONJ
admet-194	207	30	movement	movement	NOUN
admet-194	207	31	disorders	disorder	NOUN
admet-194	207	32	the	the	DET
admet-194	207	33	first	first	ADJ
admet-194	207	34	clinical	clinical	ADJ
admet-194	207	35	dbs	dbs	NOUN
admet-194	207	36	treatment	treatment	NOUN
admet-194	207	37	that	that	PRON
admet-194	207	38	approved	approve	VERB
admet-194	207	39	by	by	ADP
admet-194	207	40	the	the	DET
admet-194	207	41	food	food	NOUN
admet-194	207	42	and	and	CCONJ
admet-194	207	43	drug	drug	NOUN
admet-194	207	44	administration	administration	NOUN
admet-194	207	45	in	in	ADP
admet-194	207	46	1997	1997	NUM
admet-194	207	47	was	be	AUX
admet-194	207	48	for	for	ADP
admet-194	207	49	admet	admet	PROPN
admet-194	207	50	&	&	CCONJ
admet-194	207	51	dmpk	dmpk	PROPN
admet-194	207	52	3(3	3(3	NUM
admet-194	207	53	)	)	PUNCT
admet-194	207	54	(	(	PUNCT
admet-194	207	55	2015	2015	NUM
admet-194	207	56	)	)	PUNCT
admet-194	207	57	216	216	NUM
admet-194	207	58	-	-	SYM
admet-194	207	59	234	234	NUM
admet-194	207	60	chemical	chemical	NOUN
admet-194	207	61	and	and	CCONJ
admet-194	207	62	physical	physical	ADJ
admet-194	207	63	approaches	approach	NOUN
admet-194	207	64	for	for	ADP
admet-194	207	65	the	the	DET
admet-194	207	66	treatment	treatment	NOUN
admet-194	207	67	of	of	ADP
admet-194	207	68	ad	ad	NOUN
admet-194	207	69	doi	doi	NOUN
admet-194	207	70	:	:	PUNCT
admet-194	207	71	10.5599	10.5599	NUM
admet-194	207	72	/	/	SYM
admet-194	207	73	admet.3.3.194	admet.3.3.194	PROPN
admet-194	207	74	225	225	NUM
admet-194	207	75	essential	essential	ADJ
admet-194	207	76	tremor	tremor	NOUN
admet-194	207	77	,	,	PUNCT
admet-194	207	78	later	later	ADV
admet-194	207	79	for	for	ADP
admet-194	207	80	parkinson	parkinson	NOUN
admet-194	207	81	’s	’s	PART
admet-194	207	82	disease	disease	NOUN
admet-194	207	83	in	in	ADP
admet-194	207	84	2002	2002	NUM
admet-194	207	85	,	,	PUNCT
admet-194	207	86	then	then	ADV
admet-194	207	87	for	for	ADP
admet-194	207	88	dystonia	dystonia	NOUN
admet-194	207	89	in	in	ADP
admet-194	207	90	2003	2003	NUM
admet-194	207	91	,	,	PUNCT
admet-194	207	92	and	and	CCONJ
admet-194	207	93	obsessive	obsessive	ADJ
admet-194	207	94	-	-	PUNCT
admet-194	207	95	compulsive	compulsive	ADJ
admet-194	207	96	disorder	disorder	NOUN
admet-194	207	97	(	(	PUNCT
admet-194	207	98	ocd	ocd	NOUN
admet-194	207	99	)	)	PUNCT
admet-194	207	100	in	in	ADP
admet-194	207	101	2009	2009	NUM
admet-194	207	102	[	[	X
admet-194	207	103	116	116	NUM
admet-194	207	104	]	]	PUNCT
admet-194	207	105	.	.	PUNCT
admet-194	208	1	dbs	dbs	PROPN
admet-194	208	2	can	can	AUX
admet-194	208	3	also	also	ADV
admet-194	208	4	be	be	AUX
admet-194	208	5	used	use	VERB
admet-194	208	6	in	in	ADP
admet-194	208	7	research	research	NOUN
admet-194	208	8	studies	study	NOUN
admet-194	208	9	of	of	ADP
admet-194	208	10	major	major	ADJ
admet-194	208	11	depression	depression	NOUN
admet-194	208	12	[	[	X
admet-194	208	13	117,118	117,118	NUM
admet-194	208	14	]	]	PUNCT
admet-194	208	15	and	and	CCONJ
admet-194	208	16	other	other	ADJ
admet-194	208	17	affective	affective	ADJ
admet-194	208	18	disorders	disorder	NOUN
admet-194	208	19	[	[	X
admet-194	208	20	119	119	NUM
admet-194	208	21	]	]	PUNCT
admet-194	208	22	,	,	PUNCT
admet-194	208	23	as	as	ADV
admet-194	208	24	well	well	ADV
admet-194	208	25	as	as	ADP
admet-194	208	26	in	in	ADP
admet-194	208	27	treatment	treatment	NOUN
admet-194	208	28	of	of	ADP
admet-194	208	29	chronic	chronic	ADJ
admet-194	208	30	pain	pain	NOUN
admet-194	209	1	[	[	X
admet-194	209	2	120,121	120,121	NUM
admet-194	209	3	]	]	PUNCT
admet-194	209	4	,	,	PUNCT
admet-194	209	5	though	though	SCONJ
admet-194	209	6	none	none	NOUN
admet-194	209	7	of	of	ADP
admet-194	209	8	these	these	DET
admet-194	209	9	newer	new	ADJ
admet-194	209	10	indications	indication	NOUN
admet-194	209	11	have	have	AUX
admet-194	209	12	been	be	AUX
admet-194	209	13	approved	approve	VERB
admet-194	209	14	by	by	ADP
admet-194	209	15	fda	fda	PROPN
admet-194	209	16	till	till	SCONJ
admet-194	209	17	now	now	ADV
admet-194	209	18	,	,	PUNCT
admet-194	209	19	which	which	PRON
admet-194	209	20	may	may	AUX
admet-194	209	21	probably	probably	ADV
admet-194	209	22	due	due	ADJ
admet-194	209	23	to	to	ADP
admet-194	209	24	high	high	ADJ
admet-194	209	25	complication	complication	NOUN
admet-194	209	26	rates	rate	NOUN
admet-194	209	27	and	and	CCONJ
admet-194	209	28	side	side	NOUN
admet-194	209	29	effects	effect	NOUN
admet-194	209	30	.	.	PUNCT
admet-194	210	1	so	so	ADV
admet-194	210	2	far	far	ADV
admet-194	210	3	,	,	PUNCT
admet-194	210	4	only	only	ADV
admet-194	210	5	two	two	NUM
admet-194	210	6	feasibility	feasibility	NOUN
admet-194	210	7	studies	study	NOUN
admet-194	210	8	focusing	focus	VERB
admet-194	210	9	on	on	ADP
admet-194	210	10	fornix	fornix	NOUN
admet-194	210	11	dbs	dbs	PROPN
admet-194	211	1	[	[	X
admet-194	211	2	122	122	NUM
admet-194	211	3	,	,	PUNCT
admet-194	211	4	123	123	NUM
admet-194	211	5	]	]	PUNCT
admet-194	211	6	with	with	ADP
admet-194	211	7	published	publish	VERB
admet-194	211	8	consequences	consequence	NOUN
admet-194	211	9	and	and	CCONJ
admet-194	211	10	one	one	NUM
admet-194	211	11	case	case	NOUN
admet-194	211	12	study	study	NOUN
admet-194	211	13	[	[	X
admet-194	211	14	124	124	NUM
admet-194	211	15	]	]	PUNCT
admet-194	211	16	and	and	CCONJ
admet-194	211	17	one	one	NUM
admet-194	211	18	phase	phase	NOUN
admet-194	211	19	1	1	NUM
admet-194	211	20	trial	trial	NOUN
admet-194	211	21	[	[	X
admet-194	211	22	125	125	NUM
admet-194	211	23	]	]	PUNCT
admet-194	211	24	of	of	ADP
admet-194	211	25	nucleus	nucleus	ADJ
admet-194	211	26	basalis	basali	NOUN
admet-194	211	27	of	of	ADP
admet-194	211	28	meynert	meynert	PROPN
admet-194	211	29	(	(	PUNCT
admet-194	211	30	nbm	nbm	PROPN
admet-194	211	31	)	)	PUNCT
admet-194	211	32	dbs	dbs	PROPN
admet-194	211	33	have	have	AUX
admet-194	211	34	been	be	AUX
admet-194	211	35	undertaken	undertake	VERB
admet-194	211	36	to	to	PART
admet-194	211	37	evaluate	evaluate	VERB
admet-194	211	38	if	if	SCONJ
admet-194	211	39	this	this	DET
admet-194	211	40	method	method	NOUN
admet-194	211	41	could	could	AUX
admet-194	211	42	improve	improve	VERB
admet-194	211	43	the	the	DET
admet-194	211	44	cognitive	cognitive	ADJ
admet-194	211	45	functions	function	NOUN
admet-194	211	46	in	in	ADP
admet-194	211	47	pd	pd	NOUN
admet-194	211	48	or	or	CCONJ
admet-194	211	49	ad	ad	NOUN
admet-194	211	50	patients	patient	NOUN
admet-194	211	51	.	.	PUNCT
admet-194	212	1	3.1.1	3.1.1	NUM
admet-194	212	2	fornix	fornix	NOUN
admet-194	212	3	stimulation	stimulation	NOUN
admet-194	212	4	fornix	fornix	NOUN
admet-194	212	5	,	,	PUNCT
admet-194	212	6	a	a	DET
admet-194	212	7	c	c	NOUN
admet-194	212	8	-	-	PUNCT
admet-194	212	9	shaped	shape	VERB
admet-194	212	10	bundle	bundle	NOUN
admet-194	212	11	of	of	ADP
admet-194	212	12	fibers	fiber	NOUN
admet-194	212	13	(	(	PUNCT
admet-194	212	14	axons	axon	NOUN
admet-194	212	15	)	)	PUNCT
admet-194	212	16	in	in	ADP
admet-194	212	17	brain	brain	NOUN
admet-194	212	18	,	,	PUNCT
admet-194	212	19	is	be	AUX
admet-194	212	20	a	a	DET
admet-194	212	21	key	key	ADJ
admet-194	212	22	element	element	NOUN
admet-194	212	23	of	of	ADP
admet-194	212	24	the	the	DET
admet-194	212	25	memory	memory	NOUN
admet-194	212	26	circuitry	circuitry	NOUN
admet-194	212	27	.	.	PUNCT
admet-194	213	1	it	it	PRON
admet-194	213	2	carries	carry	VERB
admet-194	213	3	signals	signal	NOUN
admet-194	213	4	from	from	ADP
admet-194	213	5	the	the	DET
admet-194	213	6	hippocampus	hippocampus	NOUN
admet-194	213	7	to	to	ADP
admet-194	213	8	the	the	DET
admet-194	213	9	anterior	anterior	ADJ
admet-194	213	10	thalamic	thalamic	ADJ
admet-194	213	11	nuclei	nucleus	NOUN
admet-194	213	12	[	[	X
admet-194	213	13	126	126	NUM
admet-194	213	14	,	,	PUNCT
admet-194	213	15	127	127	NUM
admet-194	213	16	]	]	PUNCT
admet-194	213	17	.	.	PUNCT
admet-194	214	1	the	the	DET
admet-194	214	2	main	main	ADJ
admet-194	214	3	characters	character	NOUN
admet-194	214	4	of	of	ADP
admet-194	214	5	ad	ad	NOUN
admet-194	214	6	are	be	AUX
admet-194	214	7	the	the	DET
admet-194	214	8	damages	damage	NOUN
admet-194	214	9	of	of	ADP
admet-194	214	10	neurons	neuron	NOUN
admet-194	214	11	and	and	CCONJ
admet-194	214	12	neural	neural	ADJ
admet-194	214	13	circuits	circuit	NOUN
admet-194	214	14	which	which	PRON
admet-194	214	15	relate	relate	VERB
admet-194	214	16	to	to	ADP
admet-194	214	17	cognitive	cognitive	ADJ
admet-194	214	18	functions	function	NOUN
admet-194	214	19	.	.	PUNCT
admet-194	215	1	fornix	fornix	PROPN
admet-194	215	2	dbs	dbs	PROPN
admet-194	215	3	could	could	AUX
admet-194	215	4	have	have	VERB
admet-194	215	5	the	the	DET
admet-194	215	6	potential	potential	NOUN
admet-194	215	7	to	to	PART
admet-194	215	8	modulate	modulate	VERB
admet-194	215	9	the	the	DET
admet-194	215	10	neurophysiological	neurophysiological	ADJ
admet-194	215	11	activities	activity	NOUN
admet-194	215	12	,	,	PUNCT
admet-194	215	13	which	which	PRON
admet-194	215	14	may	may	AUX
admet-194	215	15	offer	offer	VERB
admet-194	215	16	good	good	ADJ
admet-194	215	17	clinical	clinical	ADJ
admet-194	215	18	outcomes	outcome	NOUN
admet-194	215	19	.	.	PUNCT
admet-194	216	1	in	in	ADP
admet-194	216	2	one	one	NUM
admet-194	216	3	study	study	NOUN
admet-194	216	4	,	,	PUNCT
admet-194	216	5	this	this	DET
admet-194	216	6	treatment	treatment	NOUN
admet-194	216	7	was	be	AUX
admet-194	216	8	applied	apply	VERB
admet-194	216	9	to	to	ADP
admet-194	216	10	a	a	DET
admet-194	216	11	patient	patient	NOUN
admet-194	216	12	with	with	ADP
admet-194	216	13	morbid	morbid	ADJ
admet-194	216	14	obesity	obesity	NOUN
admet-194	216	15	.	.	PUNCT
admet-194	217	1	it	it	PRON
admet-194	217	2	has	have	AUX
admet-194	217	3	been	be	AUX
admet-194	217	4	shown	show	VERB
admet-194	217	5	that	that	SCONJ
admet-194	217	6	hypothalamic	hypothalamic	ADJ
admet-194	217	7	/	/	SYM
admet-194	217	8	fornix	fornix	PROPN
admet-194	217	9	dbs	dbs	PROPN
admet-194	217	10	modulated	modulate	VERB
admet-194	217	11	limbic	limbic	ADJ
admet-194	217	12	activity	activity	NOUN
admet-194	217	13	of	of	ADP
admet-194	217	14	that	that	DET
admet-194	217	15	patient	patient	NOUN
admet-194	217	16	and	and	CCONJ
admet-194	217	17	improved	improve	VERB
admet-194	217	18	his	his	PRON
admet-194	217	19	memory	memory	NOUN
admet-194	217	20	[	[	X
admet-194	217	21	128	128	NUM
admet-194	217	22	]	]	PUNCT
admet-194	217	23	.	.	PUNCT
admet-194	218	1	then	then	ADV
admet-194	218	2	a	a	DET
admet-194	218	3	phase	phase	NOUN
admet-194	218	4	1	1	NUM
admet-194	218	5	trial	trial	NOUN
admet-194	218	6	with	with	ADP
admet-194	218	7	6	6	NUM
admet-194	218	8	mild	mild	ADJ
admet-194	218	9	ad	ad	NOUN
admet-194	218	10	patients	patient	NOUN
admet-194	218	11	was	be	AUX
admet-194	218	12	investigated	investigate	VERB
admet-194	218	13	by	by	ADP
admet-194	218	14	laxton	laxton	NOUN
admet-194	218	15	and	and	CCONJ
admet-194	218	16	his	his	PRON
admet-194	218	17	colleagues	colleague	NOUN
admet-194	218	18	[	[	X
admet-194	218	19	122	122	NUM
admet-194	218	20	]	]	PUNCT
admet-194	218	21	.	.	PUNCT
admet-194	219	1	electrodes	electrode	NOUN
admet-194	219	2	were	be	AUX
admet-194	219	3	located	locate	VERB
admet-194	219	4	2	2	NUM
admet-194	219	5	mm	mm	NOUN
admet-194	219	6	anterior	anterior	NOUN
admet-194	219	7	and	and	CCONJ
admet-194	219	8	parallel	parallel	ADJ
admet-194	219	9	to	to	ADP
admet-194	219	10	the	the	DET
admet-194	219	11	vertical	vertical	ADJ
admet-194	219	12	portion	portion	NOUN
admet-194	219	13	of	of	ADP
admet-194	219	14	the	the	DET
admet-194	219	15	fornix	fornix	NOUN
admet-194	219	16	bilaterally	bilaterally	ADV
admet-194	219	17	.	.	PUNCT
admet-194	220	1	the	the	DET
admet-194	220	2	neural	neural	ADJ
admet-194	220	3	activities	activity	NOUN
admet-194	220	4	in	in	ADP
admet-194	220	5	entorhinal	entorhinal	ADJ
admet-194	220	6	cortex	cortex	NOUN
admet-194	220	7	and	and	CCONJ
admet-194	220	8	hippocampus	hippocampus	PROPN
admet-194	220	9	,	,	PUNCT
admet-194	220	10	which	which	PRON
admet-194	220	11	was	be	AUX
admet-194	220	12	part	part	NOUN
admet-194	220	13	of	of	ADP
admet-194	220	14	the	the	DET
admet-194	220	15	memory	memory	NOUN
admet-194	220	16	circuit	circuit	NOUN
admet-194	220	17	,	,	PUNCT
admet-194	220	18	were	be	AUX
admet-194	220	19	enhanced	enhance	VERB
admet-194	220	20	by	by	ADP
admet-194	220	21	fornix	fornix	PROPN
admet-194	220	22	dbs	dbs	PROPN
admet-194	220	23	.	.	PUNCT
admet-194	221	1	the	the	DET
admet-194	221	2	damaged	damage	VERB
admet-194	221	3	glucose	glucose	NOUN
admet-194	221	4	utilization	utilization	NOUN
admet-194	221	5	in	in	ADP
admet-194	221	6	the	the	DET
admet-194	221	7	temporal	temporal	ADJ
admet-194	221	8	lobe	lobe	NOUN
admet-194	221	9	and	and	CCONJ
admet-194	221	10	parietal	parietal	ADJ
admet-194	221	11	lobe	lobe	PROPN
admet-194	221	12	was	be	AUX
admet-194	221	13	sustained	sustain	VERB
admet-194	221	14	and	and	CCONJ
admet-194	221	15	reversed	reverse	VERB
admet-194	221	16	strikingly	strikingly	ADV
admet-194	221	17	after	after	ADP
admet-194	221	18	the	the	DET
admet-194	221	19	clinical	clinical	ADJ
admet-194	221	20	dbs	dbs	NOUN
admet-194	221	21	.	.	PUNCT
admet-194	222	1	moreover	moreover	ADV
admet-194	222	2	,	,	PUNCT
admet-194	222	3	the	the	DET
admet-194	222	4	improvements	improvement	NOUN
admet-194	222	5	of	of	ADP
admet-194	222	6	cognitive	cognitive	ADJ
admet-194	222	7	functions	function	NOUN
admet-194	222	8	and/or	and/or	CCONJ
admet-194	222	9	the	the	DET
admet-194	222	10	reduction	reduction	NOUN
admet-194	222	11	in	in	ADP
admet-194	222	12	the	the	DET
admet-194	222	13	rate	rate	NOUN
admet-194	222	14	of	of	ADP
admet-194	222	15	cognitive	cognitive	ADJ
admet-194	222	16	decline	decline	NOUN
admet-194	222	17	in	in	ADP
admet-194	222	18	some	some	DET
admet-194	222	19	patients	patient	NOUN
admet-194	222	20	were	be	AUX
admet-194	222	21	clearly	clearly	ADV
admet-194	222	22	demonstrated	demonstrate	VERB
admet-194	222	23	.	.	PUNCT
admet-194	223	1	minor	minor	ADJ
admet-194	223	2	side	side	NOUN
admet-194	223	3	effects	effect	NOUN
admet-194	223	4	in	in	ADP
admet-194	223	5	some	some	DET
admet-194	223	6	patients	patient	NOUN
admet-194	223	7	were	be	AUX
admet-194	223	8	observed	observe	VERB
admet-194	223	9	,	,	PUNCT
admet-194	223	10	encompassing	encompass	VERB
admet-194	223	11	minor	minor	ADJ
admet-194	223	12	heat	heat	NOUN
admet-194	223	13	production	production	NOUN
admet-194	223	14	,	,	PUNCT
admet-194	223	15	sweating	sweating	NOUN
admet-194	223	16	,	,	PUNCT
admet-194	223	17	increases	increase	NOUN
admet-194	223	18	in	in	ADP
admet-194	223	19	blood	blood	NOUN
admet-194	223	20	pressure	pressure	NOUN
admet-194	223	21	and	and	CCONJ
admet-194	223	22	heart	heart	NOUN
admet-194	223	23	rate	rate	NOUN
admet-194	223	24	.	.	PUNCT
admet-194	224	1	a	a	DET
admet-194	224	2	feasibility	feasibility	NOUN
admet-194	224	3	study	study	NOUN
admet-194	224	4	with	with	ADP
admet-194	224	5	nine	nine	NUM
admet-194	224	6	patients	patient	NOUN
admet-194	224	7	was	be	AUX
admet-194	224	8	conducted	conduct	VERB
admet-194	224	9	by	by	ADP
admet-194	224	10	fontaine	fontaine	PROPN
admet-194	224	11	and	and	CCONJ
admet-194	224	12	his	his	PRON
admet-194	224	13	colleagues	colleague	NOUN
admet-194	224	14	to	to	PART
admet-194	224	15	explore	explore	VERB
admet-194	224	16	the	the	DET
admet-194	224	17	effect	effect	NOUN
admet-194	224	18	and	and	CCONJ
admet-194	224	19	safety	safety	NOUN
admet-194	224	20	of	of	ADP
admet-194	224	21	dbs	dbs	NOUN
admet-194	224	22	in	in	ADP
admet-194	224	23	ad	ad	NOUN
admet-194	224	24	patients	patient	NOUN
admet-194	224	25	who	who	PRON
admet-194	224	26	got	get	VERB
admet-194	224	27	mild	mild	ADJ
admet-194	224	28	cognitive	cognitive	ADJ
admet-194	224	29	deficit	deficit	NOUN
admet-194	224	30	[	[	X
admet-194	224	31	123	123	NUM
admet-194	224	32	]	]	PUNCT
admet-194	224	33	.	.	PUNCT
admet-194	225	1	however	however	ADV
admet-194	225	2	,	,	PUNCT
admet-194	225	3	only	only	ADV
admet-194	225	4	one	one	NUM
admet-194	225	5	patient	patient	NOUN
admet-194	225	6	agreed	agree	VERB
admet-194	225	7	to	to	PART
admet-194	225	8	accept	accept	VERB
admet-194	225	9	the	the	DET
admet-194	225	10	surgery	surgery	NOUN
admet-194	225	11	,	,	PUNCT
admet-194	225	12	and	and	CCONJ
admet-194	225	13	accomplished	accomplish	VERB
admet-194	225	14	the	the	DET
admet-194	225	15	study	study	NOUN
admet-194	225	16	.	.	PUNCT
admet-194	226	1	the	the	DET
admet-194	226	2	patient	patient	NOUN
admet-194	226	3	received	receive	VERB
admet-194	226	4	stimulation	stimulation	NOUN
admet-194	226	5	bilaterally	bilaterally	ADV
admet-194	226	6	for	for	ADP
admet-194	226	7	12	12	NUM
admet-194	226	8	months	month	NOUN
admet-194	226	9	,	,	PUNCT
admet-194	226	10	and	and	CCONJ
admet-194	226	11	the	the	DET
admet-194	226	12	electrode	electrode	NOUN
admet-194	226	13	target	target	NOUN
admet-194	226	14	was	be	AUX
admet-194	226	15	the	the	DET
admet-194	226	16	same	same	ADJ
admet-194	226	17	as	as	ADP
admet-194	226	18	laxton	laxton	NOUN
admet-194	226	19	’s	’s	PART
admet-194	226	20	study	study	NOUN
admet-194	226	21	.	.	PUNCT
admet-194	227	1	the	the	DET
admet-194	227	2	memory	memory	NOUN
admet-194	227	3	scores	score	NOUN
admet-194	227	4	were	be	AUX
admet-194	227	5	stabilized	stabilize	VERB
admet-194	227	6	comparing	compare	VERB
admet-194	227	7	to	to	AUX
admet-194	227	8	control	control	VERB
admet-194	227	9	conditions	condition	NOUN
admet-194	227	10	,	,	PUNCT
admet-194	227	11	and	and	CCONJ
admet-194	227	12	a	a	DET
admet-194	227	13	subjective	subjective	ADJ
admet-194	227	14	view	view	NOUN
admet-194	227	15	of	of	ADP
admet-194	227	16	memory	memory	NOUN
admet-194	227	17	improvement	improvement	NOUN
admet-194	227	18	was	be	AUX
admet-194	227	19	delivered	deliver	VERB
admet-194	227	20	by	by	ADP
admet-194	227	21	the	the	DET
admet-194	227	22	only	only	ADJ
admet-194	227	23	patient	patient	NOUN
admet-194	227	24	herself	herself	PRON
admet-194	227	25	,	,	PUNCT
admet-194	227	26	without	without	ADP
admet-194	227	27	significant	significant	ADJ
admet-194	227	28	225ehavioural	225ehavioural	ADJ
admet-194	227	29	improvement	improvement	NOUN
admet-194	227	30	or	or	CCONJ
admet-194	227	31	mood	mood	NOUN
admet-194	227	32	enhancement	enhancement	NOUN
admet-194	227	33	,	,	PUNCT
admet-194	227	34	however	however	ADV
admet-194	227	35	.	.	PUNCT
admet-194	228	1	furthermore	furthermore	ADV
admet-194	228	2	,	,	PUNCT
admet-194	228	3	the	the	DET
admet-194	228	4	glucose	glucose	NOUN
admet-194	228	5	metabolism	metabolism	NOUN
admet-194	228	6	in	in	ADP
admet-194	228	7	medial	medial	ADJ
admet-194	228	8	temporal	temporal	ADJ
admet-194	228	9	lobes	lobe	NOUN
admet-194	228	10	slightly	slightly	ADV
admet-194	228	11	increased	increase	VERB
admet-194	228	12	.	.	PUNCT
admet-194	229	1	unfortunately	unfortunately	ADV
admet-194	229	2	these	these	DET
admet-194	229	3	results	result	NOUN
admet-194	229	4	are	be	AUX
admet-194	229	5	not	not	PART
admet-194	229	6	enough	enough	ADJ
admet-194	229	7	to	to	PART
admet-194	229	8	demonstrate	demonstrate	VERB
admet-194	229	9	the	the	DET
admet-194	229	10	feasibility	feasibility	NOUN
admet-194	229	11	of	of	ADP
admet-194	229	12	the	the	DET
admet-194	229	13	technique	technique	NOUN
admet-194	229	14	due	due	ADP
admet-194	229	15	to	to	ADP
admet-194	229	16	the	the	DET
admet-194	229	17	great	great	ADJ
admet-194	229	18	limitation	limitation	NOUN
admet-194	229	19	of	of	ADP
admet-194	229	20	the	the	DET
admet-194	229	21	extremely	extremely	ADV
admet-194	229	22	small	small	ADJ
admet-194	229	23	numbers	number	NOUN
admet-194	229	24	of	of	ADP
admet-194	229	25	the	the	DET
admet-194	229	26	patients	patient	NOUN
admet-194	229	27	.	.	PUNCT
admet-194	230	1	another	another	DET
admet-194	230	2	combination	combination	NOUN
admet-194	230	3	of	of	ADP
admet-194	230	4	phase	phase	NOUN
admet-194	230	5	1	1	NUM
admet-194	230	6	and	and	CCONJ
admet-194	230	7	2	2	NUM
admet-194	230	8	trial	trial	NOUN
admet-194	230	9	of	of	ADP
admet-194	230	10	fornix	fornix	PROPN
admet-194	230	11	dbs	dbs	PROPN
admet-194	230	12	is	be	AUX
admet-194	230	13	now	now	ADV
admet-194	230	14	ongoing	ongoing	ADJ
admet-194	230	15	with	with	SCONJ
admet-194	230	16	about	about	ADV
admet-194	230	17	50	50	NUM
admet-194	230	18	mild	mild	ADJ
admet-194	230	19	probable	probable	ADJ
admet-194	230	20	ad	ad	NOUN
admet-194	230	21	patients	patient	NOUN
admet-194	230	22	to	to	PART
admet-194	230	23	evaluate	evaluate	VERB
admet-194	230	24	the	the	DET
admet-194	230	25	acute	acute	ADJ
admet-194	230	26	and	and	CCONJ
admet-194	230	27	long	long	ADJ
admet-194	230	28	-	-	PUNCT
admet-194	230	29	term	term	NOUN
admet-194	230	30	safety	safety	NOUN
admet-194	230	31	of	of	ADP
admet-194	230	32	this	this	DET
admet-194	230	33	system	system	NOUN
admet-194	230	34	[	[	X
admet-194	230	35	129	129	NUM
admet-194	230	36	]	]	PUNCT
admet-194	230	37	.	.	PUNCT
admet-194	231	1	3.1.2	3.1.2	NUM
admet-194	231	2	nucleus	nucleus	ADJ
admet-194	231	3	basalis	basali	NOUN
admet-194	231	4	of	of	ADP
admet-194	231	5	meynert	meynert	PROPN
admet-194	231	6	(	(	PUNCT
admet-194	231	7	nbm	nbm	PROPN
admet-194	231	8	)	)	PUNCT
admet-194	231	9	stimulation	stimulation	NOUN
admet-194	231	10	it	it	PRON
admet-194	231	11	has	have	AUX
admet-194	231	12	been	be	AUX
admet-194	231	13	shown	show	VERB
admet-194	231	14	that	that	SCONJ
admet-194	231	15	nbm	nbm	PROPN
admet-194	231	16	lesions	lesion	NOUN
admet-194	231	17	can	can	AUX
admet-194	231	18	result	result	VERB
admet-194	231	19	in	in	ADP
admet-194	231	20	neurodegenerative	neurodegenerative	ADJ
admet-194	231	21	changes	change	NOUN
admet-194	231	22	in	in	ADP
admet-194	231	23	hippocampal	hippocampal	ADJ
admet-194	231	24	mossy	mossy	NOUN
admet-194	231	25	fibers	fiber	NOUN
admet-194	231	26	and	and	CCONJ
admet-194	231	27	dentate	dentate	ADJ
admet-194	231	28	gyrus	gyrus	NOUN
admet-194	231	29	[	[	X
admet-194	231	30	130,131	130,131	NUM
admet-194	231	31	]	]	PUNCT
admet-194	231	32	,	,	PUNCT
admet-194	231	33	as	as	ADV
admet-194	231	34	well	well	ADV
admet-194	231	35	as	as	ADP
admet-194	231	36	the	the	DET
admet-194	231	37	nadph	nadph	ADJ
admet-194	231	38	-	-	PUNCT
admet-194	231	39	diaphorase	diaphorase	NOUN
admet-194	231	40	enhancement	enhancement	NOUN
admet-194	231	41	in	in	ADP
admet-194	231	42	the	the	DET
admet-194	231	43	dorsal	dorsal	NOUN
admet-194	231	44	ca1	ca1	PROPN
admet-194	231	45	-	-	PUNCT
admet-194	231	46	ca3	ca3	NOUN
admet-194	231	47	of	of	ADP
admet-194	231	48	the	the	DET
admet-194	231	49	hippocampus	hippocampus	NOUN
admet-194	231	50	[	[	X
admet-194	231	51	132	132	NUM
admet-194	231	52	]	]	PUNCT
admet-194	231	53	.	.	PUNCT
admet-194	232	1	characterized	characterize	VERB
admet-194	232	2	by	by	ADP
admet-194	232	3	the	the	DET
admet-194	232	4	intrinsic	intrinsic	ADJ
admet-194	232	5	organization	organization	NOUN
admet-194	232	6	,	,	PUNCT
admet-194	232	7	anatomy	anatomy	NOUN
admet-194	232	8	,	,	PUNCT
admet-194	232	9	and	and	CCONJ
admet-194	232	10	cholinergic	cholinergic	ADJ
admet-194	232	11	innervation	innervation	NOUN
admet-194	232	12	,	,	PUNCT
admet-194	232	13	nbm	nbm	PROPN
admet-194	232	14	is	be	AUX
admet-194	232	15	thought	think	VERB
admet-194	232	16	to	to	PART
admet-194	232	17	be	be	AUX
admet-194	232	18	an	an	DET
admet-194	232	19	auspicious	auspicious	ADJ
admet-194	232	20	target	target	NOUN
admet-194	232	21	structure	structure	NOUN
admet-194	232	22	for	for	ADP
admet-194	232	23	clinical	clinical	ADJ
admet-194	232	24	dbs	dbs	NOUN
admet-194	232	25	in	in	ADP
admet-194	232	26	dementia	dementia	NOUN
admet-194	232	27	.	.	PUNCT
admet-194	233	1	there	there	PRON
admet-194	233	2	is	be	VERB
admet-194	233	3	plentiful	plentiful	ADJ
admet-194	233	4	experimental	experimental	ADJ
admet-194	233	5	evidence	evidence	NOUN
admet-194	233	6	showing	show	VERB
admet-194	233	7	that	that	SCONJ
admet-194	233	8	the	the	DET
admet-194	233	9	nbm	nbm	PROPN
admet-194	233	10	projects	project	VERB
admet-194	233	11	cholinergic	cholinergic	ADJ
admet-194	233	12	innervation	innervation	NOUN
admet-194	233	13	to	to	ADP
admet-194	233	14	the	the	DET
admet-194	233	15	whole	whole	ADJ
admet-194	233	16	cortex	cortex	NOUN
admet-194	233	17	[	[	X
admet-194	233	18	133	133	NUM
admet-194	233	19	-	-	SYM
admet-194	233	20	136	136	NUM
admet-194	233	21	]	]	PUNCT
admet-194	233	22	,	,	PUNCT
admet-194	233	23	complemented	complement	VERB
admet-194	233	24	by	by	ADP
admet-194	233	25	gabaergic	gabaergic	ADJ
admet-194	233	26	projections	projection	NOUN
admet-194	233	27	and	and	CCONJ
admet-194	233	28	glutaminergic	glutaminergic	NOUN
admet-194	233	29	projections	projection	NOUN
admet-194	233	30	from	from	ADP
admet-194	233	31	basal	basal	ADJ
admet-194	233	32	forebrain	forebrain	NOUN
admet-194	233	33	[	[	X
admet-194	233	34	124,137	124,137	NUM
admet-194	233	35	]	]	PUNCT
admet-194	233	36	.	.	PUNCT
admet-194	234	1	jing	jing	PROPN
admet-194	234	2	li	li	PROPN
admet-194	234	3	et	et	PROPN
admet-194	234	4	al	al	PROPN
admet-194	234	5	.	.	PROPN
admet-194	234	6	admet	admet	PROPN
admet-194	234	7	&	&	CCONJ
admet-194	234	8	dmpk	dmpk	PROPN
admet-194	234	9	3(3	3(3	NUM
admet-194	234	10	)	)	PUNCT
admet-194	234	11	(	(	PUNCT
admet-194	234	12	2015	2015	NUM
admet-194	234	13	)	)	PUNCT
admet-194	234	14	216	216	NUM
admet-194	234	15	-	-	SYM
admet-194	234	16	234	234	NUM
admet-194	234	17	226	226	NUM
admet-194	234	18	in	in	ADP
admet-194	234	19	the	the	DET
admet-194	234	20	case	case	NOUN
admet-194	234	21	study	study	NOUN
admet-194	234	22	of	of	ADP
admet-194	234	23	freund	freund	PROPN
admet-194	234	24	and	and	CCONJ
admet-194	234	25	his	his	PRON
admet-194	234	26	colleagues	colleague	NOUN
admet-194	234	27	,	,	PUNCT
admet-194	234	28	nbm	nbm	PROPN
admet-194	234	29	dbs	dbs	PROPN
admet-194	234	30	was	be	AUX
admet-194	234	31	applied	apply	VERB
admet-194	234	32	to	to	ADP
admet-194	234	33	a	a	DET
admet-194	234	34	patient	patient	NOUN
admet-194	234	35	who	who	PRON
admet-194	234	36	got	get	VERB
admet-194	234	37	severe	severe	ADJ
admet-194	234	38	parkinson	parkinson	NOUN
admet-194	234	39	-	-	PUNCT
admet-194	234	40	dementia	dementia	NOUN
admet-194	234	41	syndrome	syndrome	NOUN
admet-194	234	42	(	(	PUNCT
admet-194	234	43	pdd	pdd	NOUN
admet-194	234	44	)	)	PUNCT
admet-194	234	45	to	to	PART
admet-194	234	46	investigate	investigate	VERB
admet-194	234	47	the	the	DET
admet-194	234	48	potential	potential	NOUN
admet-194	234	49	of	of	ADP
admet-194	234	50	this	this	DET
admet-194	234	51	new	new	ADJ
admet-194	234	52	dbs	dbs	NOUN
admet-194	234	53	strategy	strategy	NOUN
admet-194	234	54	in	in	ADP
admet-194	234	55	modifying	modify	VERB
admet-194	234	56	the	the	DET
admet-194	234	57	cognitive	cognitive	ADJ
admet-194	234	58	functions	function	NOUN
admet-194	234	59	[	[	X
admet-194	234	60	124	124	NUM
admet-194	234	61	]	]	PUNCT
admet-194	234	62	.	.	PUNCT
admet-194	235	1	the	the	DET
admet-194	235	2	only	only	ADJ
admet-194	235	3	patient	patient	NOUN
admet-194	235	4	who	who	PRON
admet-194	235	5	received	receive	VERB
admet-194	235	6	this	this	DET
admet-194	235	7	surgery	surgery	NOUN
admet-194	235	8	is	be	AUX
admet-194	235	9	a	a	DET
admet-194	235	10	71	71	NUM
admet-194	235	11	-	-	PUNCT
admet-194	235	12	year	year	NOUN
admet-194	235	13	-	-	PUNCT
admet-194	235	14	old	old	ADJ
admet-194	235	15	man	man	NOUN
admet-194	235	16	with	with	ADP
admet-194	235	17	pdd	pdd	NOUN
admet-194	235	18	.	.	PUNCT
admet-194	236	1	the	the	DET
admet-194	236	2	target	target	NOUN
admet-194	236	3	areas	area	NOUN
admet-194	236	4	were	be	AUX
admet-194	236	5	bilateral	bilateral	ADJ
admet-194	236	6	nbm	nbm	PROPN
admet-194	236	7	and	and	CCONJ
admet-194	236	8	subthalamic	subthalamic	ADJ
admet-194	236	9	nucleus	nucleus	NOUN
admet-194	236	10	(	(	PUNCT
admet-194	236	11	stn	stn	PROPN
admet-194	236	12	)	)	PUNCT
admet-194	236	13	.	.	PUNCT
admet-194	237	1	the	the	DET
admet-194	237	2	stn	stn	PROPN
admet-194	237	3	dbs	dbs	PROPN
admet-194	237	4	led	lead	VERB
admet-194	237	5	to	to	ADP
admet-194	237	6	the	the	DET
admet-194	237	7	only	only	ADJ
admet-194	237	8	improvement	improvement	NOUN
admet-194	237	9	of	of	ADP
admet-194	237	10	motor	motor	NOUN
admet-194	237	11	symptoms	symptom	NOUN
admet-194	237	12	,	,	PUNCT
admet-194	237	13	while	while	SCONJ
admet-194	237	14	the	the	DET
admet-194	237	15	nbm	nbm	PROPN
admet-194	237	16	dbs	dbs	PROPN
admet-194	237	17	resulted	result	VERB
admet-194	237	18	in	in	ADP
admet-194	237	19	significant	significant	ADJ
admet-194	237	20	improvement	improvement	NOUN
admet-194	237	21	cognitive	cognitive	ADJ
admet-194	237	22	functions	function	NOUN
admet-194	237	23	,	,	PUNCT
admet-194	237	24	including	include	VERB
admet-194	237	25	the	the	DET
admet-194	237	26	attention	attention	NOUN
admet-194	237	27	,	,	PUNCT
admet-194	237	28	alertness	alertness	NOUN
admet-194	237	29	,	,	PUNCT
admet-194	237	30	concentration	concentration	NOUN
admet-194	237	31	,	,	PUNCT
admet-194	237	32	spontaneity	spontaneity	NOUN
admet-194	237	33	,	,	PUNCT
admet-194	237	34	and	and	CCONJ
admet-194	237	35	drive	drive	NOUN
admet-194	237	36	.	.	PUNCT
admet-194	238	1	therefore	therefore	ADV
admet-194	238	2	the	the	DET
admet-194	238	3	patient	patient	NOUN
admet-194	238	4	’s	’s	PART
admet-194	238	5	executive	executive	ADJ
admet-194	238	6	and	and	CCONJ
admet-194	238	7	social	social	ADJ
admet-194	238	8	functions	function	NOUN
admet-194	238	9	had	have	AUX
admet-194	238	10	been	be	AUX
admet-194	238	11	markedly	markedly	ADV
admet-194	238	12	improved	improve	VERB
admet-194	238	13	.	.	PUNCT
admet-194	239	1	the	the	DET
admet-194	239	2	enhancements	enhancement	NOUN
admet-194	239	3	in	in	ADP
admet-194	239	4	226ehavioural	226ehavioural	ADJ
admet-194	239	5	and	and	CCONJ
admet-194	239	6	cognitive	cognitive	ADJ
admet-194	239	7	performance	performance	NOUN
admet-194	239	8	might	might	AUX
admet-194	239	9	be	be	AUX
admet-194	239	10	connected	connect	VERB
admet-194	239	11	with	with	ADP
admet-194	239	12	the	the	DET
admet-194	239	13	effects	effect	NOUN
admet-194	239	14	of	of	ADP
admet-194	239	15	irritating	irritate	VERB
admet-194	239	16	residual	residual	ADJ
admet-194	239	17	cholinergic	cholinergic	ADJ
admet-194	239	18	projections	projection	NOUN
admet-194	239	19	and	and	CCONJ
admet-194	239	20	neuronal	neuronal	ADJ
admet-194	239	21	bodies	body	NOUN
admet-194	239	22	in	in	ADP
admet-194	239	23	nbm	nbm	PROPN
admet-194	239	24	.	.	PUNCT
admet-194	240	1	a	a	DET
admet-194	240	2	clinical	clinical	ADJ
admet-194	240	3	study	study	NOUN
admet-194	240	4	with	with	ADP
admet-194	240	5	six	six	NUM
admet-194	240	6	mild	mild	ADJ
admet-194	240	7	-	-	PUNCT
admet-194	240	8	to	to	ADP
admet-194	240	9	-	-	PUNCT
admet-194	240	10	moderate	moderate	ADJ
admet-194	240	11	ad	ad	NOUN
admet-194	240	12	patients	patient	NOUN
admet-194	240	13	was	be	AUX
admet-194	240	14	conducted	conduct	VERB
admet-194	240	15	by	by	ADP
admet-194	240	16	kuhn	kuhn	PROPN
admet-194	240	17	and	and	CCONJ
admet-194	240	18	his	his	PRON
admet-194	240	19	colleagues	colleague	NOUN
admet-194	240	20	through	through	ADP
admet-194	240	21	applying	apply	VERB
admet-194	240	22	bilateral	bilateral	ADJ
admet-194	240	23	low	low	ADJ
admet-194	240	24	-	-	PUNCT
admet-194	240	25	frequency	frequency	NOUN
admet-194	240	26	nbm	nbm	PROPN
admet-194	240	27	dbs	dbs	NOUN
admet-194	241	1	[	[	X
admet-194	241	2	125	125	NUM
admet-194	241	3	]	]	PUNCT
admet-194	241	4	.	.	PUNCT
admet-194	242	1	the	the	DET
admet-194	242	2	whole	whole	ADJ
admet-194	242	3	trial	trial	NOUN
admet-194	242	4	encompassed	encompass	VERB
admet-194	242	5	a	a	DET
admet-194	242	6	4	4	NUM
admet-194	242	7	-	-	PUNCT
admet-194	242	8	week	week	NOUN
admet-194	242	9	randomized	randomize	VERB
admet-194	242	10	sham	sham	NOUN
admet-194	242	11	-	-	PUNCT
admet-194	242	12	controlled	control	VERB
admet-194	242	13	stimulation	stimulation	NOUN
admet-194	242	14	period	period	NOUN
admet-194	242	15	and	and	CCONJ
admet-194	242	16	a	a	DET
admet-194	242	17	subsequent	subsequent	ADJ
admet-194	242	18	11	11	NUM
admet-194	242	19	-	-	PUNCT
admet-194	242	20	month	month	NOUN
admet-194	242	21	continued	continue	VERB
admet-194	242	22	open	open	ADJ
admet-194	242	23	stimulation	stimulation	NOUN
admet-194	242	24	phase	phase	NOUN
admet-194	242	25	.	.	PUNCT
admet-194	243	1	the	the	DET
admet-194	243	2	consequences	consequence	NOUN
admet-194	243	3	were	be	AUX
admet-194	243	4	assessed	assess	VERB
admet-194	243	5	by	by	ADP
admet-194	243	6	cognitive	cognitive	ADJ
admet-194	243	7	subscale	subscale	NOUN
admet-194	243	8	of	of	ADP
admet-194	243	9	the	the	DET
admet-194	243	10	ad	ad	NOUN
admet-194	243	11	assessment	assessment	NOUN
admet-194	243	12	scale	scale	NOUN
admet-194	243	13	and	and	CCONJ
admet-194	243	14	other	other	ADJ
admet-194	243	15	psychological	psychological	ADJ
admet-194	243	16	tests	test	NOUN
admet-194	243	17	.	.	PUNCT
admet-194	244	1	electroencephalogram	electroencephalogram	NOUN
admet-194	244	2	(	(	PUNCT
admet-194	244	3	eeg	eeg	NOUN
admet-194	244	4	)	)	PUNCT
admet-194	244	5	and	and	CCONJ
admet-194	244	6	positron	positron	NOUN
admet-194	244	7	emission	emission	NOUN
admet-194	244	8	tomography	tomography	NOUN
admet-194	244	9	(	(	PUNCT
admet-194	244	10	pet	pet	NOUN
admet-194	244	11	)	)	PUNCT
admet-194	244	12	were	be	AUX
admet-194	244	13	also	also	ADV
admet-194	244	14	applied	apply	VERB
admet-194	244	15	to	to	PART
admet-194	244	16	access	access	VERB
admet-194	244	17	the	the	DET
admet-194	244	18	changes	change	NOUN
admet-194	244	19	before	before	ADP
admet-194	244	20	and	and	CCONJ
admet-194	244	21	psychological	psychological	ADJ
admet-194	244	22	test	test	NOUN
admet-194	244	23	after	after	ADP
admet-194	244	24	the	the	DET
admet-194	244	25	surgery	surgery	NOUN
admet-194	244	26	.	.	PUNCT
admet-194	245	1	nearly	nearly	ADV
admet-194	245	2	no	no	DET
admet-194	245	3	adverse	adverse	ADJ
admet-194	245	4	effect	effect	NOUN
admet-194	245	5	showed	show	VERB
admet-194	245	6	the	the	DET
admet-194	245	7	expected	expected	ADJ
admet-194	245	8	inner	inner	ADJ
admet-194	245	9	restlessness	restlessness	NOUN
admet-194	245	10	that	that	SCONJ
admet-194	245	11	one	one	NUM
admet-194	245	12	patient	patient	NOUN
admet-194	245	13	declared	declare	VERB
admet-194	245	14	.	.	PUNCT
admet-194	246	1	although	although	SCONJ
admet-194	246	2	the	the	DET
admet-194	246	3	patients	patient	NOUN
admet-194	246	4	’	'	PUNCT
admet-194	246	5	average	average	ADJ
admet-194	246	6	quality	quality	NOUN
admet-194	246	7	of	of	ADP
admet-194	246	8	life	life	NOUN
admet-194	246	9	did	do	AUX
admet-194	246	10	n’t	not	PART
admet-194	246	11	change	change	VERB
admet-194	246	12	,	,	PUNCT
admet-194	246	13	it	it	PRON
admet-194	246	14	could	could	AUX
admet-194	246	15	also	also	ADV
admet-194	246	16	be	be	AUX
admet-194	246	17	considered	consider	VERB
admet-194	246	18	as	as	ADP
admet-194	246	19	a	a	DET
admet-194	246	20	safe	safe	ADJ
admet-194	246	21	procedure	procedure	NOUN
admet-194	246	22	obviously	obviously	ADV
admet-194	246	23	without	without	ADP
admet-194	246	24	significant	significant	ADJ
admet-194	246	25	stimulation	stimulation	NOUN
admet-194	246	26	-	-	PUNCT
admet-194	246	27	induced	induce	VERB
admet-194	246	28	adverse	adverse	ADJ
admet-194	246	29	effects	effect	NOUN
admet-194	246	30	,	,	PUNCT
admet-194	246	31	since	since	SCONJ
admet-194	246	32	we	we	PRON
admet-194	246	33	have	have	VERB
admet-194	246	34	to	to	PART
admet-194	246	35	take	take	VERB
admet-194	246	36	all	all	DET
admet-194	246	37	limitations	limitation	NOUN
admet-194	246	38	of	of	ADP
admet-194	246	39	a	a	DET
admet-194	246	40	pilot	pilot	NOUN
admet-194	246	41	study	study	NOUN
admet-194	246	42	into	into	ADP
admet-194	246	43	consideration	consideration	NOUN
admet-194	246	44	.	.	PUNCT
admet-194	247	1	3.2	3.2	NUM
admet-194	247	2	animal	animal	NOUN
admet-194	247	3	researches	research	VERB
admet-194	247	4	related	relate	VERB
admet-194	247	5	with	with	ADP
admet-194	247	6	deep	deep	ADJ
admet-194	247	7	brain	brain	NOUN
admet-194	247	8	stimulation	stimulation	NOUN
admet-194	247	9	there	there	ADV
admet-194	247	10	are	be	VERB
admet-194	247	11	several	several	ADJ
admet-194	247	12	relevant	relevant	ADJ
admet-194	247	13	animal	animal	NOUN
admet-194	247	14	studies	study	NOUN
admet-194	247	15	concentrating	concentrate	VERB
admet-194	247	16	on	on	ADP
admet-194	247	17	dbs	dbs	ADJ
admet-194	247	18	-	-	ADJ
admet-194	247	19	induced	induced	ADJ
admet-194	247	20	changes	change	NOUN
admet-194	247	21	on	on	ADP
admet-194	247	22	behavior	behavior	NOUN
admet-194	247	23	,	,	PUNCT
admet-194	247	24	memory	memory	NOUN
admet-194	247	25	,	,	PUNCT
admet-194	247	26	cognition	cognition	NOUN
admet-194	247	27	,	,	PUNCT
admet-194	247	28	and/or	and/or	CCONJ
admet-194	247	29	neurogenesis	neurogenesis	VERB
admet-194	247	30	.	.	PUNCT
admet-194	248	1	10	10	NUM
admet-194	248	2	brain	brain	NOUN
admet-194	248	3	regions	region	NOUN
admet-194	248	4	have	have	AUX
admet-194	248	5	been	be	AUX
admet-194	248	6	explored	explore	VERB
admet-194	248	7	in	in	ADP
admet-194	248	8	different	different	ADJ
admet-194	248	9	animal	animal	NOUN
admet-194	248	10	models	model	NOUN
admet-194	248	11	to	to	PART
admet-194	248	12	investigate	investigate	VERB
admet-194	248	13	their	their	PRON
admet-194	248	14	functions	function	NOUN
admet-194	248	15	in	in	ADP
admet-194	248	16	memory	memory	NOUN
admet-194	248	17	enhancement	enhancement	NOUN
admet-194	248	18	,	,	PUNCT
admet-194	248	19	which	which	PRON
admet-194	248	20	are	be	AUX
admet-194	248	21	fornix	fornix	PROPN
admet-194	248	22	,	,	PUNCT
admet-194	248	23	nbm	nbm	PROPN
admet-194	248	24	,	,	PUNCT
admet-194	248	25	hippocampus	hippocampus	NOUN
admet-194	248	26	enthorinal	enthorinal	ADJ
admet-194	248	27	cortex	cortex	NOUN
admet-194	248	28	(	(	PUNCT
admet-194	248	29	ec	ec	PROPN
admet-194	248	30	)	)	PUNCT
admet-194	248	31	,	,	PUNCT
admet-194	248	32	midline	midline	VERB
admet-194	248	33	thalamic	thalamic	ADJ
admet-194	248	34	nuclei	nucleus	NOUN
admet-194	248	35	(	(	PUNCT
admet-194	248	36	mtn	mtn	PROPN
admet-194	248	37	)	)	PUNCT
admet-194	248	38	,	,	PUNCT
admet-194	248	39	anterior	anterior	ADJ
admet-194	248	40	thalamic	thalamic	ADJ
admet-194	248	41	nucleus	nucleus	NOUN
admet-194	248	42	(	(	PUNCT
admet-194	248	43	an	an	PROPN
admet-194	248	44	)	)	PUNCT
admet-194	248	45	,	,	PUNCT
admet-194	248	46	perforant	perforant	ADJ
admet-194	248	47	path	path	NOUN
admet-194	248	48	of	of	ADP
admet-194	248	49	hippocampus	hippocampus	NOUN
admet-194	248	50	,	,	PUNCT
admet-194	248	51	dorsal	dorsal	NOUN
admet-194	248	52	striatum	striatum	NOUN
admet-194	248	53	(	(	PUNCT
admet-194	248	54	ds	ds	NOUN
admet-194	248	55	)	)	PUNCT
admet-194	248	56	,	,	PUNCT
admet-194	248	57	anterior	anterior	ADJ
admet-194	248	58	caudate	caudate	ADJ
admet-194	248	59	nucleus	nucleus	NOUN
admet-194	248	60	,	,	PUNCT
admet-194	248	61	central	central	ADJ
admet-194	248	62	thalamus	thalamus	NOUN
admet-194	248	63	(	(	PUNCT
admet-194	248	64	ct	ct	NOUN
admet-194	248	65	)	)	PUNCT
admet-194	248	66	,	,	PUNCT
admet-194	248	67	and	and	CCONJ
admet-194	248	68	lateral	lateral	ADJ
admet-194	248	69	hypothalamus	hypothalamus	NOUN
admet-194	248	70	(	(	PUNCT
admet-194	248	71	lh	lh	PROPN
admet-194	248	72	)	)	PUNCT
admet-194	248	73	.	.	PUNCT
admet-194	249	1	3.2.1	3.2.1	NUM
admet-194	249	2	fornix	fornix	NOUN
admet-194	249	3	and	and	CCONJ
admet-194	249	4	nucleus	nucleus	ADJ
admet-194	249	5	basalis	basali	NOUN
admet-194	249	6	of	of	ADP
admet-194	249	7	meynert	meynert	PROPN
admet-194	249	8	(	(	PUNCT
admet-194	249	9	nbm	nbm	PROPN
admet-194	249	10	)	)	PUNCT
admet-194	249	11	fornix	fornix	PROPN
admet-194	249	12	dbs	dbs	PROPN
admet-194	249	13	could	could	AUX
admet-194	249	14	antagonize	antagonize	VERB
admet-194	249	15	the	the	DET
admet-194	249	16	memory	memory	NOUN
admet-194	249	17	impairing	impair	VERB
admet-194	249	18	effects	effect	NOUN
admet-194	249	19	resulting	result	VERB
admet-194	249	20	from	from	ADP
admet-194	249	21	scopolamine	scopolamine	ADJ
admet-194	249	22	injection	injection	NOUN
admet-194	249	23	in	in	ADP
admet-194	249	24	rats	rat	NOUN
admet-194	249	25	[	[	X
admet-194	249	26	138	138	NUM
admet-194	249	27	]	]	PUNCT
admet-194	249	28	.	.	PUNCT
admet-194	250	1	the	the	DET
admet-194	250	2	important	important	ADJ
admet-194	250	3	favorable	favorable	ADJ
admet-194	250	4	role	role	NOUN
admet-194	250	5	of	of	ADP
admet-194	250	6	nbm	nbm	PROPN
admet-194	250	7	dbs	dbs	PROPN
admet-194	250	8	on	on	ADP
admet-194	250	9	memory	memory	NOUN
admet-194	250	10	acquisition	acquisition	NOUN
admet-194	250	11	was	be	AUX
admet-194	250	12	investigated	investigate	VERB
admet-194	250	13	in	in	ADP
admet-194	250	14	rats	rat	NOUN
admet-194	250	15	[	[	X
admet-194	250	16	139	139	NUM
admet-194	250	17	]	]	PUNCT
admet-194	250	18	,	,	PUNCT
admet-194	250	19	in	in	ADP
admet-194	250	20	which	which	PRON
admet-194	250	21	investigators	investigator	NOUN
admet-194	250	22	considered	consider	VERB
admet-194	250	23	dbs	dbs	NOUN
admet-194	250	24	could	could	AUX
admet-194	250	25	increase	increase	VERB
admet-194	250	26	ach	ach	NOUN
admet-194	250	27	release	release	NOUN
admet-194	250	28	from	from	ADP
admet-194	250	29	nbm	nbm	PROPN
admet-194	250	30	neurons	neuron	NOUN
admet-194	250	31	that	that	SCONJ
admet-194	250	32	in	in	ADP
admet-194	250	33	return	return	NOUN
admet-194	250	34	helpfully	helpfully	ADV
admet-194	250	35	influenced	influence	VERB
admet-194	250	36	neural	neural	ADJ
admet-194	250	37	plasticity	plasticity	NOUN
admet-194	250	38	mechanisms	mechanism	NOUN
admet-194	250	39	.	.	PUNCT
admet-194	251	1	one	one	NUM
admet-194	251	2	study	study	NOUN
admet-194	251	3	suggested	suggest	VERB
admet-194	251	4	that	that	SCONJ
admet-194	251	5	pertaining	pertain	VERB
admet-194	251	6	nbm	nbm	PROPN
admet-194	251	7	electrical	electrical	ADJ
admet-194	251	8	stimulation	stimulation	NOUN
admet-194	251	9	facilitates	facilitate	VERB
admet-194	251	10	the	the	DET
admet-194	251	11	memory	memory	NOUN
admet-194	251	12	acquisition	acquisition	NOUN
admet-194	252	1	[	[	X
admet-194	252	2	140	140	NUM
admet-194	252	3	]	]	X
admet-194	252	4	,	,	PUNCT
admet-194	252	5	which	which	PRON
admet-194	252	6	supported	support	VERB
admet-194	252	7	the	the	DET
admet-194	252	8	fact	fact	NOUN
admet-194	252	9	that	that	SCONJ
admet-194	252	10	nbm	nbm	PROPN
admet-194	252	11	could	could	AUX
admet-194	252	12	play	play	VERB
admet-194	252	13	a	a	DET
admet-194	252	14	part	part	NOUN
admet-194	252	15	in	in	ADP
admet-194	252	16	the	the	DET
admet-194	252	17	early	early	ADJ
admet-194	252	18	stages	stage	NOUN
admet-194	252	19	of	of	ADP
admet-194	252	20	memory	memory	NOUN
admet-194	252	21	formation	formation	NOUN
admet-194	252	22	.	.	PUNCT
admet-194	253	1	another	another	DET
admet-194	253	2	study	study	NOUN
admet-194	253	3	also	also	ADV
admet-194	253	4	manifested	manifest	VERB
admet-194	253	5	the	the	DET
admet-194	253	6	positive	positive	ADJ
admet-194	253	7	consequences	consequence	NOUN
admet-194	253	8	of	of	ADP
admet-194	253	9	nbm	nbm	PROPN
admet-194	253	10	dbs	dbs	PROPN
admet-194	253	11	which	which	PRON
admet-194	253	12	were	be	AUX
admet-194	253	13	assistance	assistance	NOUN
admet-194	253	14	of	of	ADP
admet-194	253	15	maintain	maintain	VERB
admet-194	253	16	neuronal	neuronal	ADJ
admet-194	253	17	plasticity	plasticity	NOUN
admet-194	253	18	and	and	CCONJ
admet-194	253	19	protective	protective	ADJ
admet-194	253	20	effect	effect	NOUN
admet-194	253	21	on	on	ADP
admet-194	253	22	the	the	DET
admet-194	253	23	cortex	cortex	NOUN
admet-194	253	24	[	[	X
admet-194	253	25	141	141	NUM
admet-194	253	26	]	]	PUNCT
admet-194	253	27	.	.	PUNCT
admet-194	254	1	3.2.2	3.2.2	NUM
admet-194	254	2	hippocampus	hippocampus	NOUN
admet-194	254	3	enthorinal	enthorinal	ADJ
admet-194	254	4	cortex	cortex	NOUN
admet-194	254	5	(	(	PUNCT
admet-194	254	6	ec	ec	PROPN
admet-194	254	7	)	)	PUNCT
admet-194	254	8	application	application	NOUN
admet-194	254	9	of	of	ADP
admet-194	254	10	acute	acute	ADJ
admet-194	254	11	high	high	ADJ
admet-194	254	12	-	-	PUNCT
admet-194	254	13	frequency	frequency	NOUN
admet-194	254	14	dbs	dbs	NOUN
admet-194	254	15	in	in	ADP
admet-194	254	16	hippocampus	hippocampus	NOUN
admet-194	254	17	ec	ec	PROPN
admet-194	254	18	of	of	ADP
admet-194	254	19	mice	mouse	NOUN
admet-194	254	20	could	could	AUX
admet-194	254	21	lead	lead	VERB
admet-194	254	22	to	to	ADP
admet-194	254	23	a	a	DET
admet-194	254	24	transiently	transiently	ADV
admet-194	254	25	promoted	promote	VERB
admet-194	254	26	proliferation	proliferation	NOUN
admet-194	254	27	in	in	ADP
admet-194	254	28	the	the	DET
admet-194	254	29	dentate	dentate	ADJ
admet-194	254	30	gyrus	gyrus	NOUN
admet-194	254	31	(	(	PUNCT
admet-194	254	32	dg	dg	X
admet-194	254	33	)	)	PUNCT
admet-194	255	1	[	[	X
admet-194	255	2	142	142	NUM
admet-194	255	3	]	]	PUNCT
admet-194	255	4	,	,	PUNCT
admet-194	255	5	and	and	CCONJ
admet-194	255	6	these	these	DET
admet-194	255	7	dbs	dbs	ADJ
admet-194	255	8	-	-	ADJ
admet-194	255	9	induced	induced	ADJ
admet-194	255	10	neurons	neuron	NOUN
admet-194	255	11	merged	merge	VERB
admet-194	255	12	with	with	ADP
admet-194	255	13	hippocampal	hippocampal	ADJ
admet-194	255	14	circuits	circuit	NOUN
admet-194	255	15	once	once	SCONJ
admet-194	255	16	they	they	PRON
admet-194	255	17	were	be	AUX
admet-194	255	18	mature	mature	ADJ
admet-194	255	19	.	.	PUNCT
admet-194	256	1	3.2.3	3.2.3	NUM
admet-194	256	2	midline	midline	NOUN
admet-194	256	3	thalamic	thalamic	ADJ
admet-194	256	4	nuclei	nucleus	NOUN
admet-194	256	5	(	(	PUNCT
admet-194	256	6	mtn	mtn	PROPN
admet-194	256	7	)	)	PUNCT
admet-194	256	8	mtn	mtn	PROPN
admet-194	256	9	dbs	dbs	PROPN
admet-194	256	10	was	be	AUX
admet-194	256	11	found	find	VERB
admet-194	256	12	to	to	PART
admet-194	256	13	increase	increase	VERB
admet-194	256	14	short	short	ADJ
admet-194	256	15	-	-	PUNCT
admet-194	256	16	term	term	NOUN
admet-194	256	17	memory	memory	NOUN
admet-194	256	18	in	in	ADP
admet-194	256	19	the	the	DET
admet-194	256	20	ca1	ca1	NOUN
admet-194	256	21	of	of	ADP
admet-194	256	22	hippocampus	hippocampus	NOUN
admet-194	256	23	in	in	ADP
admet-194	256	24	transgenic	transgenic	NOUN
admet-194	256	25	mice	mouse	NOUN
admet-194	256	26	[	[	X
admet-194	256	27	143	143	NUM
admet-194	256	28	]	]	PUNCT
admet-194	256	29	with	with	ADP
admet-194	256	30	the	the	DET
admet-194	256	31	results	result	NOUN
admet-194	256	32	of	of	ADP
admet-194	256	33	enhancing	enhance	VERB
admet-194	256	34	object	object	NOUN
admet-194	256	35	recognition	recognition	NOUN
admet-194	256	36	memory	memory	NOUN
admet-194	256	37	during	during	ADP
admet-194	256	38	behavioral	behavioral	ADJ
admet-194	256	39	studies	study	NOUN
admet-194	256	40	and	and	CCONJ
admet-194	256	41	promoting	promote	VERB
admet-194	256	42	synaptic	synaptic	ADJ
admet-194	256	43	plasticity	plasticity	NOUN
admet-194	256	44	in	in	ADP
admet-194	256	45	ca1	ca1	PROPN
admet-194	256	46	of	of	ADP
admet-194	256	47	hippocampal	hippocampal	ADJ
admet-194	256	48	slices	slice	NOUN
admet-194	256	49	.	.	PUNCT
admet-194	257	1	3.2.4	3.2.4	NUM
admet-194	257	2	anterior	anterior	ADJ
admet-194	257	3	nucleus	nucleus	NOUN
admet-194	257	4	(	(	PUNCT
admet-194	257	5	an	an	NOUN
admet-194	257	6	)	)	PUNCT
admet-194	257	7	of	of	ADP
admet-194	257	8	the	the	DET
admet-194	257	9	thalamus	thalamus	NOUN
admet-194	257	10	admet	admet	PROPN
admet-194	257	11	&	&	CCONJ
admet-194	257	12	dmpk	dmpk	PROPN
admet-194	257	13	3(3	3(3	NUM
admet-194	257	14	)	)	PUNCT
admet-194	257	15	(	(	PUNCT
admet-194	257	16	2015	2015	NUM
admet-194	257	17	)	)	PUNCT
admet-194	257	18	216	216	NUM
admet-194	257	19	-	-	SYM
admet-194	257	20	234	234	NUM
admet-194	257	21	chemical	chemical	NOUN
admet-194	257	22	and	and	CCONJ
admet-194	257	23	physical	physical	ADJ
admet-194	257	24	approaches	approach	NOUN
admet-194	257	25	for	for	ADP
admet-194	257	26	the	the	DET
admet-194	257	27	treatment	treatment	NOUN
admet-194	257	28	of	of	ADP
admet-194	257	29	ad	ad	NOUN
admet-194	257	30	doi	doi	NOUN
admet-194	257	31	:	:	PUNCT
admet-194	257	32	10.5599	10.5599	NUM
admet-194	257	33	/	/	SYM
admet-194	257	34	admet.3.3.194	admet.3.3.194	PROPN
admet-194	257	35	227	227	NUM
admet-194	257	36	the	the	DET
admet-194	257	37	role	role	NOUN
admet-194	257	38	of	of	ADP
admet-194	257	39	an	an	DET
admet-194	257	40	dbs	dbs	NOUN
admet-194	257	41	in	in	ADP
admet-194	257	42	memory	memory	NOUN
admet-194	257	43	might	might	AUX
admet-194	257	44	depend	depend	VERB
admet-194	257	45	on	on	ADP
admet-194	257	46	current	current	ADJ
admet-194	257	47	intensity	intensity	NOUN
admet-194	257	48	[	[	X
admet-194	257	49	144	144	NUM
admet-194	257	50	]	]	PUNCT
admet-194	257	51	.	.	PUNCT
admet-194	258	1	high	high	ADJ
admet-194	258	2	current	current	ADJ
admet-194	258	3	treatment	treatment	NOUN
admet-194	258	4	improved	improve	VERB
admet-194	258	5	hippocampal	hippocampal	ADJ
admet-194	258	6	activity	activity	NOUN
admet-194	258	7	,	,	PUNCT
admet-194	258	8	while	while	SCONJ
admet-194	258	9	relatively	relatively	ADV
admet-194	258	10	high	high	ADJ
admet-194	258	11	current	current	ADJ
admet-194	258	12	disrupted	disrupt	VERB
admet-194	258	13	memory	memory	NOUN
admet-194	258	14	acquisition	acquisition	NOUN
admet-194	258	15	.	.	PUNCT
admet-194	259	1	interestingly	interestingly	ADV
admet-194	259	2	,	,	PUNCT
admet-194	259	3	the	the	DET
admet-194	259	4	results	result	NOUN
admet-194	259	5	of	of	ADP
admet-194	259	6	the	the	DET
admet-194	259	7	other	other	ADJ
admet-194	259	8	study	study	NOUN
admet-194	259	9	of	of	ADP
admet-194	259	10	the	the	DET
admet-194	259	11	same	same	ADJ
admet-194	259	12	research	research	NOUN
admet-194	259	13	group	group	NOUN
admet-194	259	14	showed	show	VERB
admet-194	259	15	that	that	SCONJ
admet-194	259	16	the	the	DET
admet-194	259	17	positive	positive	ADJ
admet-194	259	18	role	role	NOUN
admet-194	259	19	of	of	ADP
admet-194	259	20	an	an	DET
admet-194	259	21	dbs	dbs	NOUN
admet-194	259	22	on	on	ADP
admet-194	259	23	memory	memory	NOUN
admet-194	259	24	and	and	CCONJ
admet-194	259	25	neurogenesis	neurogenesis	NOUN
admet-194	259	26	seemed	seem	VERB
admet-194	259	27	to	to	PART
admet-194	259	28	be	be	AUX
admet-194	259	29	dependent	dependent	ADJ
admet-194	259	30	on	on	ADP
admet-194	259	31	long	long	ADJ
admet-194	259	32	-	-	PUNCT
admet-194	259	33	term	term	NOUN
admet-194	259	34	plastic	plastic	NOUN
admet-194	259	35	changes	change	NOUN
admet-194	259	36	,	,	PUNCT
admet-194	259	37	leading	lead	VERB
admet-194	259	38	to	to	ADP
admet-194	259	39	memory	memory	NOUN
admet-194	259	40	enhancement	enhancement	NOUN
admet-194	259	41	when	when	SCONJ
admet-194	259	42	the	the	DET
admet-194	259	43	training	training	NOUN
admet-194	259	44	was	be	AUX
admet-194	259	45	conducted	conduct	VERB
admet-194	259	46	at	at	ADP
admet-194	259	47	longer	long	ADJ
admet-194	259	48	intervals	interval	NOUN
admet-194	259	49	[	[	X
admet-194	259	50	144	144	NUM
admet-194	259	51	]	]	PUNCT
admet-194	259	52	.	.	PUNCT
admet-194	260	1	another	another	DET
admet-194	260	2	study	study	NOUN
admet-194	260	3	also	also	ADV
admet-194	260	4	demonstrated	demonstrate	VERB
admet-194	260	5	that	that	SCONJ
admet-194	260	6	an	an	DET
admet-194	260	7	dbs	dbs	NOUN
admet-194	260	8	in	in	ADP
admet-194	260	9	rats	rat	NOUN
admet-194	260	10	had	have	VERB
admet-194	260	11	the	the	DET
admet-194	260	12	ability	ability	NOUN
admet-194	260	13	to	to	PART
admet-194	260	14	improve	improve	VERB
admet-194	260	15	the	the	DET
admet-194	260	16	hippocampal	hippocampal	ADJ
admet-194	260	17	neurogenesis	neurogenesis	NOUN
admet-194	260	18	and	and	CCONJ
admet-194	260	19	reverse	reverse	VERB
admet-194	260	20	experimentally	experimentally	ADV
admet-194	260	21	inhibited	inhibit	VERB
admet-194	260	22	neurogenesis	neurogenesis	NOUN
admet-194	260	23	[	[	X
admet-194	260	24	145	145	NUM
admet-194	260	25	]	]	PUNCT
admet-194	260	26	.	.	PUNCT
admet-194	261	1	3.2.5	3.2.5	NUM
admet-194	261	2	perforant	perforant	ADJ
admet-194	261	3	path	path	NOUN
admet-194	261	4	of	of	ADP
admet-194	261	5	hippocampus	hippocampus	NOUN
admet-194	261	6	the	the	DET
admet-194	261	7	perforant	perforant	ADJ
admet-194	261	8	path	path	NOUN
admet-194	261	9	is	be	AUX
admet-194	261	10	the	the	DET
admet-194	261	11	connection	connection	NOUN
admet-194	261	12	which	which	PRON
admet-194	261	13	originates	originate	VERB
admet-194	261	14	from	from	ADP
admet-194	261	15	the	the	DET
admet-194	261	16	hippocampus	hippocampus	PROPN
admet-194	261	17	ec	ec	PROPN
admet-194	261	18	,	,	PUNCT
admet-194	261	19	and	and	CCONJ
admet-194	261	20	projects	project	NOUN
admet-194	261	21	into	into	ADP
admet-194	261	22	all	all	DET
admet-194	261	23	areas	area	NOUN
admet-194	261	24	of	of	ADP
admet-194	261	25	the	the	DET
admet-194	261	26	hippocampus	hippocampus	NOUN
admet-194	261	27	.	.	PUNCT
admet-194	262	1	it	it	PRON
admet-194	262	2	triggers	trigger	VERB
admet-194	262	3	θ	θ	ADJ
admet-194	262	4	-	-	PUNCT
admet-194	262	5	phase	phase	NOUN
admet-194	262	6	resetting	resetting	NOUN
admet-194	262	7	and	and	CCONJ
admet-194	262	8	the	the	DET
admet-194	262	9	release	release	NOUN
admet-194	262	10	of	of	ADP
admet-194	262	11	ach	ach	PROPN
admet-194	262	12	,	,	PUNCT
admet-194	262	13	the	the	DET
admet-194	262	14	necessary	necessary	ADJ
admet-194	262	15	condition	condition	NOUN
admet-194	262	16	of	of	ADP
admet-194	262	17	long	long	ADJ
admet-194	262	18	-	-	PUNCT
admet-194	262	19	term	term	NOUN
admet-194	262	20	potentiation	potentiation	NOUN
admet-194	262	21	(	(	PUNCT
admet-194	262	22	ltp	ltp	NOUN
admet-194	262	23	)	)	PUNCT
admet-194	263	1	[	[	X
admet-194	263	2	14	14	NUM
admet-194	263	3	]	]	PUNCT
admet-194	263	4	.	.	PUNCT
admet-194	264	1	one	one	NUM
admet-194	264	2	study	study	NOUN
admet-194	264	3	investigated	investigate	VERB
admet-194	264	4	whether	whether	SCONJ
admet-194	264	5	perforant	perforant	ADJ
admet-194	264	6	path	path	NOUN
admet-194	264	7	dbs	dbs	PROPN
admet-194	264	8	intervened	intervene	VERB
admet-194	264	9	with	with	ADP
admet-194	264	10	the	the	DET
admet-194	264	11	circuits	circuit	NOUN
admet-194	264	12	related	relate	VERB
admet-194	264	13	to	to	ADP
admet-194	264	14	encoding	encode	VERB
admet-194	264	15	and	and	CCONJ
admet-194	264	16	retrieving	retrieve	VERB
admet-194	264	17	the	the	DET
admet-194	264	18	information	information	NOUN
admet-194	264	19	of	of	ADP
admet-194	264	20	the	the	DET
admet-194	264	21	received	receive	VERB
admet-194	264	22	stimuli	stimulus	NOUN
admet-194	264	23	in	in	ADP
admet-194	264	24	the	the	DET
admet-194	264	25	working	working	NOUN
admet-194	264	26	memory	memory	NOUN
admet-194	264	27	task	task	NOUN
admet-194	264	28	[	[	X
admet-194	264	29	146	146	NUM
admet-194	264	30	]	]	PUNCT
admet-194	264	31	.	.	PUNCT
admet-194	265	1	the	the	DET
admet-194	265	2	result	result	NOUN
admet-194	265	3	could	could	AUX
admet-194	265	4	be	be	AUX
admet-194	265	5	explained	explain	VERB
admet-194	265	6	through	through	ADP
admet-194	265	7	this	this	DET
admet-194	265	8	way	way	NOUN
admet-194	265	9	:	:	PUNCT
admet-194	265	10	θ	θ	ADJ
admet-194	265	11	-	-	PUNCT
admet-194	265	12	phase	phase	NOUN
admet-194	265	13	resetting	resetting	NOUN
admet-194	265	14	might	might	AUX
admet-194	265	15	synchronize	synchronize	VERB
admet-194	265	16	stimuli	stimulus	NOUN
admet-194	265	17	with	with	ADP
admet-194	265	18	the	the	DET
admet-194	265	19	neural	neural	ADJ
admet-194	265	20	circuits	circuit	NOUN
admet-194	265	21	in	in	ADP
admet-194	265	22	hippocampus	hippocampus	NOUN
admet-194	265	23	to	to	PART
admet-194	265	24	ensure	ensure	VERB
admet-194	265	25	the	the	DET
admet-194	265	26	favorable	favorable	ADJ
admet-194	265	27	conditions	condition	NOUN
admet-194	265	28	to	to	PART
admet-194	265	29	facilitate	facilitate	VERB
admet-194	265	30	the	the	DET
admet-194	265	31	encoding	encoding	NOUN
admet-194	265	32	of	of	ADP
admet-194	265	33	the	the	DET
admet-194	265	34	received	receive	VERB
admet-194	265	35	information	information	NOUN
admet-194	265	36	into	into	ADP
admet-194	265	37	memory	memory	NOUN
admet-194	265	38	.	.	PUNCT
admet-194	266	1	3.2.6	3.2.6	NUM
admet-194	266	2	other	other	ADJ
admet-194	266	3	brain	brain	NOUN
admet-194	266	4	regions	region	NOUN
admet-194	266	5	there	there	PRON
admet-194	266	6	are	be	VERB
admet-194	266	7	other	other	ADJ
admet-194	266	8	four	four	NUM
admet-194	266	9	brain	brain	NOUN
admet-194	266	10	regions	region	NOUN
admet-194	266	11	related	relate	VERB
admet-194	266	12	to	to	ADP
admet-194	266	13	dementia	dementia	NOUN
admet-194	266	14	where	where	SCONJ
admet-194	266	15	dbs	dbs	PROPN
admet-194	266	16	could	could	AUX
admet-194	266	17	play	play	VERB
admet-194	266	18	a	a	DET
admet-194	266	19	role	role	NOUN
admet-194	266	20	,	,	PUNCT
admet-194	266	21	which	which	PRON
admet-194	266	22	are	be	AUX
admet-194	266	23	dorsal	dorsal	NOUN
admet-194	266	24	stritum	stritum	NOUN
admet-194	266	25	,	,	PUNCT
admet-194	266	26	anterior	anterior	ADJ
admet-194	266	27	caudate	caudate	ADJ
admet-194	266	28	nucleus	nucleus	NOUN
admet-194	266	29	,	,	PUNCT
admet-194	266	30	central	central	ADJ
admet-194	266	31	thalamus	thalamus	NOUN
admet-194	266	32	and	and	CCONJ
admet-194	266	33	lateral	lateral	ADJ
admet-194	266	34	hypothalamus	hypothalamus	PROPN
admet-194	266	35	.	.	PUNCT
admet-194	267	1	dorsal	dorsal	NOUN
admet-194	267	2	stritum	stritum	PROPN
admet-194	267	3	has	have	AUX
admet-194	267	4	been	be	AUX
admet-194	267	5	shown	show	VERB
admet-194	267	6	to	to	PART
admet-194	267	7	relate	relate	VERB
admet-194	267	8	to	to	ADP
admet-194	267	9	procedural	procedural	ADJ
admet-194	267	10	memory	memory	NOUN
admet-194	267	11	[	[	X
admet-194	267	12	147	147	NUM
admet-194	267	13	]	]	PUNCT
admet-194	267	14	.	.	PUNCT
admet-194	268	1	anterior	anterior	ADJ
admet-194	268	2	caudate	caudate	NOUN
admet-194	268	3	nucleus	nucleus	NOUN
admet-194	268	4	is	be	AUX
admet-194	268	5	in	in	ADP
admet-194	268	6	charge	charge	NOUN
admet-194	268	7	of	of	ADP
admet-194	268	8	implementing	implement	VERB
admet-194	268	9	selective	selective	ADJ
admet-194	268	10	adjustments	adjustment	NOUN
admet-194	268	11	to	to	ADP
admet-194	268	12	the	the	DET
admet-194	268	13	‘	'	PUNCT
admet-194	268	14	associative	associative	ADJ
admet-194	268	15	weights	weight	NOUN
admet-194	268	16	’	'	PUNCT
admet-194	268	17	between	between	ADP
admet-194	268	18	sensory	sensory	ADJ
admet-194	268	19	cues	cue	NOUN
admet-194	268	20	and	and	CCONJ
admet-194	268	21	motor	motor	NOUN
admet-194	268	22	responses	response	NOUN
admet-194	268	23	during	during	ADP
admet-194	268	24	the	the	DET
admet-194	268	25	learning	learning	NOUN
admet-194	268	26	period	period	NOUN
admet-194	268	27	[	[	X
admet-194	268	28	148	148	NUM
admet-194	268	29	]	]	PUNCT
admet-194	268	30	.	.	PUNCT
admet-194	269	1	dbs	dbs	PROPN
admet-194	269	2	in	in	ADP
admet-194	269	3	central	central	ADJ
admet-194	269	4	thalamus	thalamus	NOUN
admet-194	269	5	could	could	AUX
admet-194	269	6	lead	lead	VERB
admet-194	269	7	to	to	ADP
admet-194	269	8	a	a	DET
admet-194	269	9	complicated	complicated	ADJ
admet-194	269	10	situation	situation	NOUN
admet-194	269	11	in	in	ADP
admet-194	269	12	arousal	arousal	NOUN
admet-194	269	13	,	,	PUNCT
admet-194	269	14	behavior	behavior	NOUN
admet-194	269	15	,	,	PUNCT
admet-194	269	16	and	and	CCONJ
admet-194	269	17	cognition	cognition	NOUN
admet-194	269	18	[	[	X
admet-194	269	19	149	149	NUM
admet-194	269	20	-	-	NUM
admet-194	269	21	151	151	NUM
admet-194	269	22	]	]	PUNCT
admet-194	269	23	.	.	PUNCT
admet-194	270	1	with	with	ADP
admet-194	270	2	regard	regard	NOUN
admet-194	270	3	to	to	ADP
admet-194	270	4	the	the	DET
admet-194	270	5	lateral	lateral	ADJ
admet-194	270	6	hypothalamus	hypothalamus	NOUN
admet-194	270	7	,	,	PUNCT
admet-194	270	8	the	the	DET
admet-194	270	9	post	post	ADJ
admet-194	270	10	-	-	ADJ
admet-194	270	11	training	training	ADJ
admet-194	270	12	icss	icss	NOUN
admet-194	270	13	(	(	PUNCT
admet-194	270	14	the	the	DET
admet-194	270	15	intracranial	intracranial	ADJ
admet-194	270	16	self	self	NOUN
admet-194	270	17	-	-	PUNCT
admet-194	270	18	stimulation	stimulation	NOUN
admet-194	270	19	)	)	PUNCT
admet-194	270	20	could	could	AUX
admet-194	270	21	enhance	enhance	VERB
admet-194	270	22	the	the	DET
admet-194	270	23	hippocampus	hippocampus	NOUN
admet-194	270	24	-	-	PUNCT
admet-194	270	25	dependent	dependent	ADJ
admet-194	270	26	memories	memory	NOUN
admet-194	270	27	via	via	ADP
admet-194	270	28	improving	improve	VERB
admet-194	270	29	molecular	molecular	ADJ
admet-194	270	30	and	and	CCONJ
admet-194	270	31	cellular	cellular	ADJ
admet-194	270	32	mechanisms	mechanism	NOUN
admet-194	270	33	associated	associate	VERB
admet-194	270	34	with	with	ADP
admet-194	270	35	synaptic	synaptic	ADJ
admet-194	270	36	plasticity	plasticity	NOUN
admet-194	270	37	,	,	PUNCT
admet-194	270	38	neurogenesis	neurogenesis	NOUN
admet-194	270	39	,	,	PUNCT
admet-194	270	40	and	and	CCONJ
admet-194	270	41	neuroprotection	neuroprotection	NOUN
admet-194	270	42	[	[	X
admet-194	270	43	152	152	NUM
admet-194	270	44	-	-	SYM
admet-194	270	45	155	155	NUM
admet-194	270	46	]	]	PUNCT
admet-194	270	47	.	.	PUNCT
admet-194	271	1	4	4	X
admet-194	271	2	.	.	X
admet-194	271	3	conclusions	conclusion	NOUN
admet-194	271	4	researches	research	VERB
admet-194	271	5	on	on	ADP
admet-194	271	6	ad	ad	NOUN
admet-194	271	7	therapy	therapy	NOUN
admet-194	271	8	have	have	AUX
admet-194	271	9	had	have	VERB
admet-194	271	10	some	some	DET
admet-194	271	11	success	success	NOUN
admet-194	271	12	in	in	ADP
admet-194	271	13	the	the	DET
admet-194	271	14	field	field	NOUN
admet-194	271	15	of	of	ADP
admet-194	271	16	symptomatic	symptomatic	ADJ
admet-194	271	17	treatments	treatment	NOUN
admet-194	271	18	,	,	PUNCT
admet-194	271	19	but	but	CCONJ
admet-194	271	20	there	there	PRON
admet-194	271	21	have	have	AUX
admet-194	271	22	also	also	ADV
admet-194	271	23	been	be	AUX
admet-194	271	24	many	many	ADJ
admet-194	271	25	failures	failure	NOUN
admet-194	271	26	in	in	ADP
admet-194	271	27	the	the	DET
admet-194	271	28	development	development	NOUN
admet-194	271	29	of	of	ADP
admet-194	271	30	disease	disease	NOUN
admet-194	271	31	-	-	PUNCT
admet-194	271	32	modifying	modify	VERB
admet-194	271	33	drugs	drug	NOUN
admet-194	271	34	.	.	PUNCT
admet-194	272	1	in	in	ADP
admet-194	272	2	spite	spite	NOUN
admet-194	272	3	of	of	ADP
admet-194	272	4	the	the	DET
admet-194	272	5	frustrating	frustrating	ADJ
admet-194	272	6	research	research	NOUN
admet-194	272	7	progress	progress	NOUN
admet-194	272	8	,	,	PUNCT
admet-194	272	9	more	more	ADJ
admet-194	272	10	and	and	CCONJ
admet-194	272	11	more	more	ADJ
admet-194	272	12	researchers	researcher	NOUN
admet-194	272	13	and	and	CCONJ
admet-194	272	14	clinicians	clinician	NOUN
admet-194	272	15	are	be	AUX
admet-194	272	16	dedicating	dedicate	VERB
admet-194	272	17	all	all	DET
admet-194	272	18	their	their	PRON
admet-194	272	19	energy	energy	NOUN
admet-194	272	20	to	to	ADP
admet-194	272	21	fighting	fight	VERB
admet-194	272	22	with	with	ADP
admet-194	272	23	this	this	DET
admet-194	272	24	complicated	complicated	ADJ
admet-194	272	25	disease	disease	NOUN
admet-194	272	26	,	,	PUNCT
admet-194	272	27	and	and	CCONJ
admet-194	272	28	still	still	ADV
admet-194	272	29	more	more	ADV
admet-194	272	30	and	and	CCONJ
admet-194	272	31	more	more	ADV
admet-194	272	32	clinical	clinical	ADJ
admet-194	272	33	and	and	CCONJ
admet-194	272	34	experimental	experimental	ADJ
admet-194	272	35	studies	study	NOUN
admet-194	272	36	are	be	AUX
admet-194	272	37	now	now	ADV
admet-194	272	38	underway	underway	ADJ
admet-194	272	39	.	.	PUNCT
admet-194	273	1	it	it	PRON
admet-194	273	2	would	would	AUX
admet-194	273	3	be	be	AUX
admet-194	273	4	beneficial	beneficial	ADJ
admet-194	273	5	to	to	PART
admet-194	273	6	explore	explore	VERB
admet-194	273	7	different	different	ADJ
admet-194	273	8	approaches	approach	NOUN
admet-194	273	9	to	to	PART
admet-194	273	10	narrow	narrow	VERB
admet-194	273	11	the	the	DET
admet-194	273	12	gap	gap	NOUN
admet-194	273	13	between	between	ADP
admet-194	273	14	successful	successful	ADJ
admet-194	273	15	preclinical	preclinical	ADJ
admet-194	273	16	investigations	investigation	NOUN
admet-194	273	17	and	and	CCONJ
admet-194	273	18	unsuccessful	unsuccessful	ADJ
admet-194	273	19	clinical	clinical	ADJ
admet-194	273	20	studies	study	NOUN
admet-194	273	21	via	via	ADP
admet-194	273	22	the	the	DET
admet-194	273	23	rationalization	rationalization	NOUN
admet-194	273	24	of	of	ADP
admet-194	273	25	the	the	DET
admet-194	273	26	disease	disease	NOUN
admet-194	273	27	progression	progression	NOUN
admet-194	273	28	mechanisms	mechanism	NOUN
admet-194	273	29	.	.	PUNCT
admet-194	274	1	chemical	chemical	NOUN
admet-194	274	2	approaches	approach	NOUN
admet-194	274	3	we	we	PRON
admet-194	274	4	have	have	AUX
admet-194	274	5	discussed	discuss	VERB
admet-194	274	6	here	here	ADV
admet-194	274	7	are	be	AUX
admet-194	274	8	divided	divide	VERB
admet-194	274	9	into	into	ADP
admet-194	274	10	two	two	NUM
admet-194	274	11	categories	category	NOUN
admet-194	274	12	,	,	PUNCT
admet-194	274	13	one	one	NUM
admet-194	274	14	is	be	AUX
admet-194	274	15	disease	disease	NOUN
admet-194	274	16	-	-	PUNCT
admet-194	274	17	modifying	modify	VERB
admet-194	274	18	therapeutic	therapeutic	ADJ
admet-194	274	19	approaches	approach	NOUN
admet-194	274	20	,	,	PUNCT
admet-194	274	21	and	and	CCONJ
admet-194	274	22	the	the	DET
admet-194	274	23	other	other	ADJ
admet-194	274	24	is	be	AUX
admet-194	274	25	symptomatic	symptomatic	ADJ
admet-194	274	26	treatments	treatment	NOUN
admet-194	274	27	,	,	PUNCT
admet-194	274	28	in	in	ADP
admet-194	274	29	which	which	PRON
admet-194	274	30	the	the	DET
admet-194	274	31	former	former	ADJ
admet-194	274	32	is	be	AUX
admet-194	274	33	focused	focus	VERB
admet-194	274	34	on	on	ADP
admet-194	274	35	the	the	DET
admet-194	274	36	aβ	aβ	NOUN
admet-194	274	37	cascade	cascade	NOUN
admet-194	274	38	and	and	CCONJ
admet-194	274	39	hyperphosphorylated	hyperphosphorylate	VERB
admet-194	274	40	tau	tau	PROPN
admet-194	274	41	protein	protein	NOUN
admet-194	274	42	,	,	PUNCT
admet-194	274	43	and	and	CCONJ
admet-194	274	44	the	the	DET
admet-194	274	45	latter	latter	ADJ
admet-194	274	46	is	be	AUX
admet-194	274	47	concentrated	concentrate	VERB
admet-194	274	48	on	on	ADP
admet-194	274	49	cholinesterase	cholinesterase	NOUN
admet-194	274	50	and	and	CCONJ
admet-194	274	51	amda	amda	ADJ
admet-194	274	52	receptor	receptor	NOUN
admet-194	274	53	.	.	PUNCT
admet-194	275	1	many	many	ADJ
admet-194	275	2	clinical	clinical	ADJ
admet-194	275	3	studies	study	NOUN
admet-194	275	4	of	of	ADP
admet-194	275	5	disease	disease	NOUN
admet-194	275	6	-	-	PUNCT
admet-194	275	7	modifying	modify	VERB
admet-194	275	8	drugs	drug	NOUN
admet-194	275	9	failed	fail	VERB
admet-194	275	10	,	,	PUNCT
admet-194	275	11	and	and	CCONJ
admet-194	275	12	still	still	ADV
admet-194	275	13	many	many	ADJ
admet-194	275	14	are	be	AUX
admet-194	275	15	now	now	ADV
admet-194	275	16	being	be	AUX
admet-194	275	17	kept	keep	VERB
admet-194	275	18	ongoing	ongoing	ADJ
admet-194	275	19	,	,	PUNCT
admet-194	275	20	but	but	CCONJ
admet-194	275	21	the	the	DET
admet-194	275	22	symptomatic	symptomatic	ADJ
admet-194	275	23	therapies	therapy	NOUN
admet-194	275	24	have	have	AUX
admet-194	275	25	received	receive	VERB
admet-194	275	26	some	some	DET
admet-194	275	27	successes	success	NOUN
admet-194	275	28	.	.	PUNCT
admet-194	276	1	it	it	PRON
admet-194	276	2	is	be	AUX
admet-194	276	3	difficult	difficult	ADJ
admet-194	276	4	for	for	SCONJ
admet-194	276	5	us	we	PRON
admet-194	276	6	to	to	PART
admet-194	276	7	estimate	estimate	VERB
admet-194	276	8	the	the	PRON
admet-194	276	9	when	when	SCONJ
admet-194	276	10	the	the	DET
admet-194	276	11	successful	successful	ADJ
admet-194	276	12	treatment	treatment	NOUN
admet-194	276	13	of	of	ADP
admet-194	276	14	ad	ad	NOUN
admet-194	276	15	will	will	AUX
admet-194	276	16	be	be	AUX
admet-194	276	17	available	available	ADJ
admet-194	276	18	,	,	PUNCT
admet-194	276	19	but	but	CCONJ
admet-194	276	20	it	it	PRON
admet-194	276	21	is	be	AUX
admet-194	276	22	easy	easy	ADJ
admet-194	276	23	for	for	SCONJ
admet-194	276	24	us	we	PRON
admet-194	276	25	to	to	PART
admet-194	276	26	tell	tell	VERB
admet-194	276	27	that	that	SCONJ
admet-194	276	28	the	the	DET
admet-194	276	29	consequences	consequence	NOUN
admet-194	276	30	from	from	ADP
admet-194	276	31	clinical	clinical	ADJ
admet-194	276	32	researches	research	NOUN
admet-194	276	33	are	be	AUX
admet-194	276	34	not	not	PART
admet-194	276	35	in	in	ADP
admet-194	276	36	accordance	accordance	NOUN
admet-194	276	37	with	with	ADP
admet-194	276	38	optimistic	optimistic	ADJ
admet-194	276	39	preclinical	preclinical	ADJ
admet-194	276	40	studies	study	NOUN
admet-194	276	41	.	.	PUNCT
admet-194	277	1	the	the	DET
admet-194	277	2	pessimistic	pessimistic	ADJ
admet-194	277	3	outcomes	outcome	NOUN
admet-194	277	4	of	of	ADP
admet-194	277	5	most	most	ADJ
admet-194	277	6	clinical	clinical	ADJ
admet-194	277	7	studies	study	NOUN
admet-194	277	8	may	may	AUX
admet-194	277	9	be	be	AUX
admet-194	277	10	partly	partly	ADV
admet-194	277	11	due	due	ADJ
admet-194	277	12	to	to	ADP
admet-194	277	13	diverse	diverse	ADJ
admet-194	277	14	errors	error	NOUN
admet-194	277	15	,	,	PUNCT
admet-194	277	16	which	which	PRON
admet-194	277	17	can	can	AUX
admet-194	277	18	be	be	AUX
admet-194	277	19	categorized	categorize	VERB
admet-194	277	20	into	into	ADP
admet-194	277	21	the	the	DET
admet-194	277	22	choice	choice	NOUN
admet-194	277	23	of	of	ADP
admet-194	277	24	patients	patient	NOUN
admet-194	277	25	,	,	PUNCT
admet-194	277	26	the	the	DET
admet-194	277	27	choice	choice	NOUN
admet-194	277	28	of	of	ADP
admet-194	277	29	drugs	drug	NOUN
admet-194	277	30	,	,	PUNCT
admet-194	277	31	the	the	DET
admet-194	277	32	outcome	outcome	NOUN
admet-194	277	33	measurements	measurement	NOUN
admet-194	277	34	,	,	PUNCT
admet-194	277	35	trial	trial	NOUN
admet-194	277	36	protocols	protocol	NOUN
admet-194	277	37	,	,	PUNCT
admet-194	277	38	and	and	CCONJ
admet-194	277	39	optimization	optimization	NOUN
admet-194	277	40	of	of	ADP
admet-194	277	41	resources	resource	NOUN
admet-194	277	42	[	[	X
admet-194	277	43	13	13	NUM
admet-194	277	44	]	]	PUNCT
admet-194	277	45	.	.	PUNCT
admet-194	278	1	clearly	clearly	ADV
admet-194	278	2	,	,	PUNCT
admet-194	278	3	the	the	DET
admet-194	278	4	problem	problem	NOUN
admet-194	278	5	is	be	AUX
admet-194	278	6	largely	largely	ADV
admet-194	278	7	due	due	ADJ
admet-194	278	8	to	to	ADP
admet-194	278	9	our	our	PRON
admet-194	278	10	limited	limited	ADJ
admet-194	278	11	knowledge	knowledge	NOUN
admet-194	278	12	to	to	ADP
admet-194	278	13	the	the	DET
admet-194	278	14	pathogenesis	pathogenesis	NOUN
admet-194	278	15	of	of	ADP
admet-194	278	16	ad	ad	NOUN
admet-194	278	17	.	.	PUNCT
admet-194	279	1	as	as	SCONJ
admet-194	279	2	ad	ad	NOUN
admet-194	279	3	is	be	AUX
admet-194	279	4	a	a	DET
admet-194	279	5	jing	jing	NOUN
admet-194	279	6	li	li	PROPN
admet-194	279	7	et	et	PROPN
admet-194	279	8	al	al	PROPN
admet-194	279	9	.	.	PROPN
admet-194	279	10	admet	admet	PROPN
admet-194	279	11	&	&	CCONJ
admet-194	279	12	dmpk	dmpk	PROPN
admet-194	279	13	3(3	3(3	NUM
admet-194	279	14	)	)	PUNCT
admet-194	279	15	(	(	PUNCT
admet-194	279	16	2015	2015	NUM
admet-194	279	17	)	)	PUNCT
admet-194	279	18	216	216	NUM
admet-194	279	19	-	-	SYM
admet-194	279	20	234	234	NUM
admet-194	279	21	228	228	NUM
admet-194	279	22	complex	complex	ADJ
admet-194	279	23	multifactorial	multifactorial	ADJ
admet-194	279	24	disorder	disorder	NOUN
admet-194	279	25	[	[	X
admet-194	279	26	156	156	NUM
admet-194	279	27	]	]	PUNCT
admet-194	279	28	,	,	PUNCT
admet-194	279	29	the	the	DET
admet-194	279	30	details	detail	NOUN
admet-194	279	31	of	of	ADP
admet-194	279	32	its	its	PRON
admet-194	279	33	pathogenesis	pathogenesis	NOUN
admet-194	279	34	are	be	AUX
admet-194	279	35	not	not	PART
admet-194	279	36	yet	yet	ADV
admet-194	279	37	fully	fully	ADV
admet-194	279	38	understood	understand	VERB
admet-194	279	39	to	to	PART
admet-194	279	40	support	support	VERB
admet-194	279	41	the	the	DET
admet-194	279	42	development	development	NOUN
admet-194	279	43	of	of	ADP
admet-194	279	44	viable	viable	ADJ
admet-194	279	45	drug	drug	NOUN
admet-194	279	46	targets	target	NOUN
admet-194	279	47	and	and	CCONJ
admet-194	279	48	therapeutic	therapeutic	ADJ
admet-194	279	49	agents	agent	NOUN
admet-194	279	50	.	.	PUNCT
admet-194	280	1	how	how	SCONJ
admet-194	280	2	to	to	PART
admet-194	280	3	solve	solve	VERB
admet-194	280	4	this	this	DET
admet-194	280	5	problem	problem	NOUN
admet-194	280	6	?	?	PUNCT
admet-194	281	1	on	on	ADP
admet-194	281	2	one	one	NUM
admet-194	281	3	hand	hand	NOUN
admet-194	281	4	,	,	PUNCT
admet-194	281	5	we	we	PRON
admet-194	281	6	need	need	VERB
admet-194	281	7	to	to	PART
admet-194	281	8	do	do	VERB
admet-194	281	9	further	further	ADJ
admet-194	281	10	research	research	NOUN
admet-194	281	11	to	to	PART
admet-194	281	12	explore	explore	VERB
admet-194	281	13	the	the	DET
admet-194	281	14	real	real	ADJ
admet-194	281	15	pathogenesis	pathogenesis	NOUN
admet-194	281	16	of	of	ADP
admet-194	281	17	ad	ad	NOUN
admet-194	281	18	,	,	PUNCT
admet-194	281	19	not	not	PART
admet-194	281	20	only	only	ADV
admet-194	281	21	limited	limit	VERB
admet-194	281	22	to	to	ADP
admet-194	281	23	aβ	aβ	NOUN
admet-194	281	24	cascade	cascade	NOUN
admet-194	281	25	and	and	CCONJ
admet-194	281	26	hyperphosphorylated	hyperphosphorylate	VERB
admet-194	281	27	tau	tau	NOUN
admet-194	281	28	;	;	PUNCT
admet-194	281	29	on	on	ADP
admet-194	281	30	the	the	DET
admet-194	281	31	other	other	ADJ
admet-194	281	32	hand	hand	NOUN
admet-194	281	33	,	,	PUNCT
admet-194	281	34	the	the	DET
admet-194	281	35	strategies	strategy	NOUN
admet-194	281	36	of	of	ADP
admet-194	281	37	one	one	NUM
admet-194	281	38	drug	drug	NOUN
admet-194	281	39	directing	directing	NOUN
admet-194	281	40	at	at	ADP
admet-194	281	41	one	one	NUM
admet-194	281	42	disease	disease	NOUN
admet-194	281	43	hypothesis	hypothesis	NOUN
admet-194	281	44	to	to	PART
admet-194	281	45	develop	develop	VERB
admet-194	281	46	ad	ad	NOUN
admet-194	281	47	therapies	therapy	NOUN
admet-194	281	48	need	need	VERB
admet-194	281	49	to	to	PART
admet-194	281	50	be	be	AUX
admet-194	281	51	revised	revise	VERB
admet-194	281	52	,	,	PUNCT
admet-194	281	53	for	for	ADP
admet-194	281	54	a	a	DET
admet-194	281	55	single	single	ADJ
admet-194	281	56	pathogenic	pathogenic	ADJ
admet-194	281	57	pathway	pathway	NOUN
admet-194	281	58	for	for	ADP
admet-194	281	59	ad	ad	NOUN
admet-194	281	60	is	be	AUX
admet-194	281	61	not	not	PART
admet-194	281	62	possible	possible	ADJ
admet-194	281	63	to	to	PART
admet-194	281	64	be	be	AUX
admet-194	281	65	identified	identify	VERB
admet-194	281	66	[	[	PUNCT
admet-194	281	67	13	13	NUM
admet-194	281	68	]	]	PUNCT
admet-194	281	69	.	.	PUNCT
admet-194	282	1	physical	physical	ADJ
admet-194	282	2	approach	approach	NOUN
admet-194	282	3	using	use	VERB
admet-194	282	4	dbs	dbs	PROPN
admet-194	282	5	seems	seem	VERB
admet-194	282	6	to	to	PART
admet-194	282	7	be	be	AUX
admet-194	282	8	a	a	DET
admet-194	282	9	feasible	feasible	ADJ
admet-194	282	10	and	and	CCONJ
admet-194	282	11	safe	safe	ADJ
admet-194	282	12	treatment	treatment	NOUN
admet-194	282	13	for	for	ADP
admet-194	282	14	patients	patient	NOUN
admet-194	282	15	with	with	ADP
admet-194	282	16	dementia	dementia	NOUN
admet-194	282	17	,	,	PUNCT
admet-194	282	18	in	in	ADP
admet-194	282	19	consideration	consideration	NOUN
admet-194	282	20	of	of	ADP
admet-194	282	21	the	the	DET
admet-194	282	22	general	general	ADJ
admet-194	282	23	low	low	ADJ
admet-194	282	24	complication	complication	NOUN
admet-194	282	25	rate	rate	NOUN
admet-194	282	26	in	in	ADP
admet-194	282	27	about	about	ADV
admet-194	282	28	100,000	100,000	NUM
admet-194	282	29	pd	pd	NOUN
admet-194	282	30	patients	patient	NOUN
admet-194	282	31	treated	treat	VERB
admet-194	282	32	with	with	ADP
admet-194	282	33	dbs	dbs	PROPN
admet-194	282	34	all	all	ADV
admet-194	282	35	over	over	ADP
admet-194	282	36	the	the	DET
admet-194	282	37	world	world	NOUN
admet-194	283	1	[	[	X
admet-194	283	2	157,158	157,158	NUM
admet-194	283	3	]	]	PUNCT
admet-194	283	4	.	.	PUNCT
admet-194	284	1	currently	currently	ADV
admet-194	284	2	,	,	PUNCT
admet-194	284	3	the	the	DET
admet-194	284	4	fornix	fornix	NOUN
admet-194	284	5	is	be	AUX
admet-194	284	6	the	the	DET
admet-194	284	7	most	most	ADV
admet-194	284	8	frequently	frequently	ADV
admet-194	284	9	chosen	choose	VERB
admet-194	284	10	targeting	targeting	NOUN
admet-194	284	11	area	area	NOUN
admet-194	284	12	for	for	ADP
admet-194	284	13	treating	treat	VERB
admet-194	284	14	dementia	dementia	NOUN
admet-194	284	15	,	,	PUNCT
admet-194	284	16	including	include	VERB
admet-194	284	17	ad	ad	NOUN
admet-194	284	18	and	and	CCONJ
admet-194	284	19	pdd	pdd	NOUN
admet-194	284	20	,	,	PUNCT
admet-194	284	21	according	accord	VERB
admet-194	284	22	to	to	ADP
admet-194	284	23	the	the	DET
admet-194	284	24	extremely	extremely	ADV
admet-194	284	25	small	small	ADJ
admet-194	284	26	number	number	NOUN
admet-194	284	27	of	of	ADP
admet-194	284	28	cases	case	NOUN
admet-194	284	29	.	.	PUNCT
admet-194	285	1	the	the	DET
admet-194	285	2	potential	potential	NOUN
admet-194	285	3	of	of	ADP
admet-194	285	4	the	the	DET
admet-194	285	5	nbm	nbm	PROPN
admet-194	285	6	for	for	ADP
admet-194	285	7	dbs	dbs	PROPN
admet-194	285	8	treatment	treatment	NOUN
admet-194	285	9	in	in	ADP
admet-194	285	10	dementia	dementia	NOUN
admet-194	285	11	is	be	AUX
admet-194	285	12	auspicious	auspicious	ADJ
admet-194	285	13	,	,	PUNCT
admet-194	285	14	which	which	PRON
admet-194	285	15	may	may	AUX
admet-194	285	16	be	be	AUX
admet-194	285	17	due	due	ADJ
admet-194	285	18	to	to	ADP
admet-194	285	19	its	its	PRON
admet-194	285	20	characteristics	characteristic	NOUN
admet-194	285	21	in	in	ADP
admet-194	285	22	the	the	DET
admet-194	285	23	anatomy	anatomy	NOUN
admet-194	285	24	,	,	PUNCT
admet-194	285	25	connectivity	connectivity	NOUN
admet-194	285	26	of	of	ADP
admet-194	285	27	the	the	DET
admet-194	285	28	cholinergic	cholinergic	ADJ
admet-194	285	29	nucleus	nucleus	NOUN
admet-194	285	30	,	,	PUNCT
admet-194	285	31	and	and	CCONJ
admet-194	285	32	intrinsic	intrinsic	ADJ
admet-194	285	33	organization	organization	NOUN
admet-194	285	34	.	.	PUNCT
admet-194	286	1	other	other	ADJ
admet-194	286	2	brain	brain	NOUN
admet-194	286	3	structures	structure	NOUN
admet-194	286	4	we	we	PRON
admet-194	286	5	have	have	AUX
admet-194	286	6	already	already	ADV
admet-194	286	7	mentioned	mention	VERB
admet-194	286	8	are	be	AUX
admet-194	286	9	still	still	ADV
admet-194	286	10	lack	lack	NOUN
admet-194	286	11	of	of	ADP
admet-194	286	12	human	human	ADJ
admet-194	286	13	data	datum	NOUN
admet-194	286	14	.	.	PUNCT
admet-194	287	1	the	the	DET
admet-194	287	2	situation	situation	NOUN
admet-194	287	3	in	in	ADP
admet-194	287	4	human	human	ADJ
admet-194	287	5	brain	brain	NOUN
admet-194	287	6	is	be	AUX
admet-194	287	7	much	much	ADV
admet-194	287	8	more	more	ADV
admet-194	287	9	complicated	complicated	ADJ
admet-194	287	10	and	and	CCONJ
admet-194	287	11	intricate	intricate	ADJ
admet-194	287	12	.	.	PUNCT
admet-194	288	1	the	the	DET
admet-194	288	2	recruitment	recruitment	NOUN
admet-194	288	3	of	of	ADP
admet-194	288	4	patients	patient	NOUN
admet-194	288	5	in	in	ADP
admet-194	288	6	clinical	clinical	ADJ
admet-194	288	7	evaluation	evaluation	NOUN
admet-194	288	8	in	in	ADP
admet-194	288	9	dbs	dbs	PROPN
admet-194	288	10	study	study	NOUN
admet-194	288	11	on	on	ADP
admet-194	288	12	ad	ad	NOUN
admet-194	288	13	was	be	AUX
admet-194	288	14	not	not	PART
admet-194	288	15	easy	easy	ADJ
admet-194	288	16	.	.	PUNCT
admet-194	289	1	clearly	clearly	ADV
admet-194	289	2	there	there	PRON
admet-194	289	3	is	be	VERB
admet-194	289	4	an	an	DET
admet-194	289	5	important	important	ADJ
admet-194	289	6	role	role	NOUN
admet-194	289	7	in	in	ADP
admet-194	289	8	the	the	DET
admet-194	289	9	preclinical	preclinical	ADJ
admet-194	289	10	animal	animal	NOUN
admet-194	289	11	research	research	NOUN
admet-194	289	12	of	of	ADP
admet-194	289	13	dbs	dbs	NOUN
admet-194	289	14	for	for	ADP
admet-194	289	15	ad	ad	NOUN
admet-194	289	16	,	,	PUNCT
admet-194	289	17	which	which	PRON
admet-194	289	18	is	be	AUX
admet-194	289	19	extremely	extremely	ADV
admet-194	289	20	limited	limited	ADJ
admet-194	289	21	at	at	ADP
admet-194	289	22	present	present	ADJ
admet-194	289	23	,	,	PUNCT
admet-194	289	24	though	though	ADV
admet-194	289	25	.	.	PUNCT
admet-194	290	1	with	with	ADP
admet-194	290	2	this	this	DET
admet-194	290	3	data	data	NOUN
admet-194	290	4	,	,	PUNCT
admet-194	290	5	it	it	PRON
admet-194	290	6	may	may	AUX
admet-194	290	7	be	be	AUX
admet-194	290	8	possible	possible	ADJ
admet-194	290	9	to	to	PART
admet-194	290	10	move	move	VERB
admet-194	290	11	toward	toward	ADP
admet-194	290	12	the	the	DET
admet-194	290	13	rationalization	rationalization	NOUN
admet-194	290	14	of	of	ADP
admet-194	290	15	the	the	DET
admet-194	290	16	mechanisms	mechanism	NOUN
admet-194	290	17	leading	lead	VERB
admet-194	290	18	to	to	ADP
admet-194	290	19	the	the	DET
admet-194	290	20	disease	disease	NOUN
admet-194	290	21	progression	progression	NOUN
admet-194	290	22	.	.	PUNCT
admet-194	291	1	it	it	PRON
admet-194	291	2	must	must	AUX
admet-194	291	3	be	be	AUX
admet-194	291	4	emphasized	emphasize	VERB
admet-194	291	5	that	that	SCONJ
admet-194	291	6	continuing	continue	VERB
admet-194	291	7	preclinical	preclinical	ADJ
admet-194	291	8	animal	animal	NOUN
admet-194	291	9	experiments	experiment	NOUN
admet-194	291	10	and	and	CCONJ
admet-194	291	11	clinical	clinical	ADJ
admet-194	291	12	studies	study	NOUN
admet-194	291	13	are	be	AUX
admet-194	291	14	utmost	utmost	ADJ
admet-194	291	15	important	important	ADJ
admet-194	291	16	to	to	PART
admet-194	291	17	demonstrate	demonstrate	VERB
admet-194	291	18	the	the	DET
admet-194	291	19	promising	promising	ADJ
admet-194	291	20	efficacy	efficacy	NOUN
admet-194	291	21	of	of	ADP
admet-194	291	22	dbs	dbs	PROPN
admet-194	291	23	in	in	ADP
admet-194	291	24	future	future	ADJ
admet-194	291	25	treatment	treatment	NOUN
admet-194	291	26	of	of	ADP
admet-194	291	27	ad	ad	NOUN
admet-194	291	28	.	.	PUNCT
admet-194	292	1	apparently	apparently	ADV
admet-194	292	2	,	,	PUNCT
admet-194	292	3	dbs	dbs	PROPN
admet-194	292	4	is	be	AUX
admet-194	292	5	being	be	AUX
admet-194	292	6	used	use	VERB
admet-194	292	7	in	in	ADP
admet-194	292	8	the	the	DET
admet-194	292	9	general	general	ADJ
admet-194	292	10	population	population	NOUN
admet-194	292	11	now	now	ADV
admet-194	292	12	.	.	PUNCT
admet-194	293	1	yet	yet	ADV
admet-194	293	2	,	,	PUNCT
admet-194	293	3	the	the	DET
admet-194	293	4	strategies	strategy	NOUN
admet-194	293	5	to	to	PART
admet-194	293	6	find	find	VERB
admet-194	293	7	satisfactory	satisfactory	ADJ
admet-194	293	8	pharmacotherapeutics	pharmacotherapeutic	NOUN
admet-194	293	9	breakthrough	breakthrough	NOUN
admet-194	293	10	are	be	AUX
admet-194	293	11	quite	quite	ADV
admet-194	293	12	limited	limited	ADJ
admet-194	293	13	.	.	PUNCT
admet-194	294	1	therefore	therefore	ADV
admet-194	294	2	,	,	PUNCT
admet-194	294	3	dbs	dbs	PROPN
admet-194	294	4	may	may	AUX
admet-194	294	5	be	be	AUX
admet-194	294	6	a	a	DET
admet-194	294	7	good	good	ADJ
admet-194	294	8	option	option	NOUN
admet-194	294	9	for	for	ADP
admet-194	294	10	some	some	DET
admet-194	294	11	ad	ad	NOUN
admet-194	294	12	patients	patient	NOUN
admet-194	294	13	if	if	SCONJ
admet-194	294	14	it	it	PRON
admet-194	294	15	is	be	AUX
admet-194	294	16	proved	prove	VERB
admet-194	294	17	to	to	PART
admet-194	294	18	be	be	AUX
admet-194	294	19	a	a	DET
admet-194	294	20	valid	valid	ADJ
admet-194	294	21	treatment	treatment	NOUN
admet-194	294	22	.	.	PUNCT
admet-194	295	1	as	as	SCONJ
admet-194	295	2	more	more	ADV
admet-194	295	3	clinical	clinical	ADJ
admet-194	295	4	data	datum	NOUN
admet-194	295	5	emerge	emerge	VERB
admet-194	295	6	,	,	PUNCT
admet-194	295	7	it	it	PRON
admet-194	295	8	will	will	AUX
admet-194	295	9	be	be	AUX
admet-194	295	10	possible	possible	ADJ
admet-194	295	11	to	to	PART
admet-194	295	12	properly	properly	ADV
admet-194	295	13	evaluate	evaluate	VERB
admet-194	295	14	the	the	DET
admet-194	295	15	applications	application	NOUN
admet-194	295	16	of	of	ADP
admet-194	295	17	dbs	dbs	NOUN
admet-194	295	18	in	in	ADP
admet-194	295	19	the	the	DET
admet-194	295	20	treatment	treatment	NOUN
admet-194	295	21	of	of	ADP
admet-194	295	22	ad	ad	NOUN
admet-194	295	23	and	and	CCONJ
admet-194	295	24	other	other	ADJ
admet-194	295	25	dementia	dementia	NOUN
admet-194	295	26	.	.	PUNCT
admet-194	296	1	acknowledgement	acknowledgement	NOUN
admet-194	296	2	we	we	PRON
admet-194	296	3	thank	thank	VERB
admet-194	296	4	the	the	DET
admet-194	296	5	financial	financial	ADJ
admet-194	296	6	support	support	NOUN
admet-194	296	7	from	from	ADP
admet-194	296	8	the	the	DET
admet-194	296	9	science	science	NOUN
admet-194	296	10	and	and	CCONJ
admet-194	296	11	technology	technology	NOUN
admet-194	296	12	development	development	NOUN
admet-194	296	13	fund	fund	PROPN
admet-194	296	14	,	,	PUNCT
admet-194	296	15	macao	macao	PROPN
admet-194	296	16	s.a.r	s.a.r	PROPN
admet-194	296	17	(	(	PUNCT
admet-194	296	18	fdct	fdct	PROPN
admet-194	296	19	)	)	PUNCT
admet-194	296	20	(	(	PUNCT
admet-194	296	21	project	project	NOUN
admet-194	296	22	reference	reference	NOUN
admet-194	296	23	no	no	INTJ
admet-194	296	24	.	.	PUNCT
admet-194	297	1	:	:	PUNCT
admet-194	297	2	118/2013	118/2013	NUM
admet-194	297	3	/	/	SYM
admet-194	297	4	a3	a3	NOUN
admet-194	297	5	)	)	PUNCT
admet-194	297	6	.	.	PUNCT
admet-194	298	1	references	reference	NOUN
admet-194	298	2	[	[	X
admet-194	298	3	1	1	X
admet-194	298	4	]	]	X
admet-194	298	5	y.	y.	PROPN
admet-194	298	6	hong	hong	PROPN
admet-194	298	7	-	-	PUNCT
admet-194	298	8	qi	qi	PROPN
admet-194	298	9	,	,	PUNCT
admet-194	298	10	s.	s.	PROPN
admet-194	298	11	zhi	zhi	PROPN
admet-194	298	12	-	-	PUNCT
admet-194	298	13	kun	kun	PROPN
admet-194	298	14	,	,	PUNCT
admet-194	298	15	c.	c.	PROPN
admet-194	298	16	sheng	sheng	PROPN
admet-194	298	17	-	-	PUNCT
admet-194	298	18	di	di	PROPN
admet-194	298	19	,	,	PUNCT
admet-194	298	20	translational	translational	ADJ
admet-194	298	21	neurodegeneration	neurodegeneration	NOUN
admet-194	298	22	1	1	NUM
admet-194	298	23	(	(	PUNCT
admet-194	298	24	2012	2012	NUM
admet-194	298	25	)	)	PUNCT
admet-194	298	26	21	21	NUM
admet-194	298	27	.	.	PUNCT
admet-194	299	1	[	[	X
admet-194	299	2	2	2	X
admet-194	299	3	]	]	PUNCT
admet-194	299	4	j.	j.	PROPN
admet-194	299	5	hardy	hardy	PROPN
admet-194	299	6	,	,	PUNCT
admet-194	299	7	neuron	neuron	VERB
admet-194	299	8	52	52	NUM
admet-194	299	9	(	(	PUNCT
admet-194	299	10	2006	2006	NUM
admet-194	299	11	)	)	PUNCT
admet-194	299	12	3	3	NUM
admet-194	299	13	-	-	SYM
admet-194	299	14	13	13	NUM
admet-194	299	15	.	.	PUNCT
admet-194	300	1	[	[	X
admet-194	300	2	3	3	X
admet-194	300	3	]	]	PUNCT
admet-194	300	4	z.	z.	PROPN
admet-194	300	5	s.	s.	PROPN
admet-194	300	6	khachaturian	khachaturian	PROPN
admet-194	300	7	,	,	PUNCT
admet-194	300	8	archives	archive	NOUN
admet-194	300	9	of	of	ADP
admet-194	300	10	neurology	neurology	NOUN
admet-194	300	11	42	42	NUM
admet-194	300	12	(	(	PUNCT
admet-194	300	13	1985	1985	NUM
admet-194	300	14	)	)	PUNCT
admet-194	300	15	1097	1097	NUM
admet-194	300	16	-	-	SYM
admet-194	300	17	1105	1105	NUM
admet-194	300	18	.	.	PUNCT
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admet-194	301	2	4	4	X
admet-194	301	3	]	]	PUNCT
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admet-194	301	7	,	,	PUNCT
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admet-194	301	10	,	,	PUNCT
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admet-194	301	16	c.	c.	PROPN
admet-194	301	17	mohs	mohs	PROPN
admet-194	301	18	,	,	PUNCT
admet-194	301	19	a.	a.	NOUN
admet-194	301	20	heyman	heyman	PROPN
admet-194	301	21	,	,	PUNCT
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admet-194	301	25	49	49	NUM
admet-194	301	26	(	(	PUNCT
admet-194	301	27	1992	1992	NUM
admet-194	301	28	)	)	PUNCT
admet-194	301	29	448452	448452	NUM
admet-194	301	30	.	.	PUNCT
admet-194	302	1	[	[	X
admet-194	302	2	5	5	X
admet-194	302	3	]	]	PUNCT
admet-194	302	4	s.	s.	PROPN
admet-194	302	5	artero	artero	PROPN
admet-194	302	6	,	,	PUNCT
admet-194	302	7	m.	m.	PROPN
admet-194	302	8	c.	c.	PROPN
admet-194	302	9	tierney	tierney	PROPN
admet-194	302	10	,	,	PUNCT
admet-194	302	11	j.	j.	PROPN
admet-194	302	12	touchon	touchon	PROPN
admet-194	302	13	,	,	PUNCT
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admet-194	302	16	,	,	PUNCT
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admet-194	302	21	(	(	PUNCT
admet-194	302	22	2003	2003	NUM
admet-194	302	23	)	)	PUNCT
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admet-194	302	25	-	-	SYM
admet-194	302	26	393	393	NUM
admet-194	302	27	.	.	PUNCT
admet-194	303	1	[	[	X
admet-194	303	2	6	6	NUM
admet-194	303	3	]	]	PUNCT
admet-194	303	4	r.	r.	PROPN
admet-194	303	5	j.	j.	PROPN
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admet-194	303	7	,	,	PUNCT
admet-194	303	8	j.	j.	PROPN
admet-194	303	9	r.	r.	PROPN
admet-194	303	10	hodges	hodges	PROPN
admet-194	303	11	,	,	PUNCT
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admet-194	303	13	122	122	NUM
admet-194	303	14	(	(	PUNCT
admet-194	303	15	1999	1999	NUM
admet-194	303	16	)	)	PUNCT
admet-194	303	17	383	383	NUM
admet-194	303	18	-	-	SYM
admet-194	303	19	404	404	NUM
admet-194	303	20	.	.	PUNCT
admet-194	304	1	[	[	X
admet-194	304	2	7	7	X
admet-194	304	3	]	]	X
admet-194	304	4	m.	m.	NOUN
admet-194	304	5	a.	a.	PROPN
admet-194	304	6	l.	l.	PROPN
admet-194	304	7	ralph	ralph	PROPN
admet-194	304	8	,	,	PUNCT
admet-194	304	9	k.	k.	PROPN
admet-194	304	10	patterson	patterson	PROPN
admet-194	304	11	,	,	PUNCT
admet-194	304	12	n.	n.	PROPN
admet-194	304	13	graham	graham	PROPN
admet-194	304	14	,	,	PUNCT
admet-194	304	15	k.	k.	PROPN
admet-194	304	16	dawson	dawson	PROPN
admet-194	304	17	,	,	PUNCT
admet-194	304	18	j.	j.	PROPN
admet-194	304	19	r.	r.	PROPN
admet-194	304	20	hodges	hodges	PROPN
admet-194	304	21	,	,	PUNCT
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admet-194	304	23	126	126	NUM
admet-194	304	24	(	(	PUNCT
admet-194	304	25	2003	2003	NUM
admet-194	304	26	)	)	PUNCT
admet-194	304	27	2350	2350	NUM
admet-194	304	28	-	-	SYM
admet-194	304	29	2362	2362	NUM
admet-194	304	30	.	.	PUNCT
admet-194	305	1	[	[	X
admet-194	305	2	8	8	NUM
admet-194	305	3	]	]	X
admet-194	305	4	d.	d.	PROPN
admet-194	305	5	j.	j.	PROPN
admet-194	305	6	selkoe	selkoe	PROPN
admet-194	305	7	,	,	PUNCT
admet-194	305	8	journal	journal	PROPN
admet-194	305	9	of	of	ADP
admet-194	305	10	alzheimer	alzheimer	PROPN
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admet-194	305	12	disesae	disesae	NOUN
admet-194	305	13	3	3	NUM
admet-194	305	14	(	(	PUNCT
admet-194	305	15	2001	2001	NUM
admet-194	305	16	)	)	PUNCT
admet-194	305	17	75	75	NUM
admet-194	305	18	-	-	SYM
admet-194	305	19	80	80	NUM
admet-194	305	20	.	.	PUNCT
admet-194	306	1	[	[	X
admet-194	306	2	9	9	X
admet-194	306	3	]	]	PUNCT
admet-194	306	4	p.	p.	NOUN
admet-194	306	5	h.	h.	PROPN
admet-194	306	6	reddy	reddy	PROPN
admet-194	306	7	,	,	PUNCT
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admet-194	306	10	1415	1415	NUM
admet-194	306	11	(	(	PUNCT
admet-194	306	12	2011	2011	NUM
admet-194	306	13	)	)	PUNCT
admet-194	306	14	136	136	NUM
admet-194	306	15	-	-	SYM
admet-194	306	16	148	148	NUM
admet-194	306	17	.	.	PUNCT
admet-194	307	1	[	[	X
admet-194	307	2	10	10	NUM
admet-194	307	3	]	]	PUNCT
admet-194	307	4	b.	b.	PROPN
admet-194	307	5	p.	p.	PROPN
admet-194	307	6	tseng	tseng	PROPN
admet-194	307	7	,	,	PUNCT
admet-194	307	8	k.	k.	PROPN
admet-194	307	9	n.	n.	PROPN
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admet-194	307	11	,	,	PUNCT
admet-194	307	12	j.	j.	PROPN
admet-194	307	13	l.	l.	PROPN
admet-194	307	14	chan	chan	PROPN
admet-194	307	15	,	,	PUNCT
admet-194	307	16	m.	m.	PROPN
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admet-194	307	18	-	-	PUNCT
admet-194	307	19	jones	jones	PROPN
admet-194	307	20	,	,	PUNCT
admet-194	307	21	f.	f.	PROPN
admet-194	307	22	m.	m.	PROPN
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admet-194	307	24	,	,	PUNCT
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admet-194	307	26	of	of	ADP
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admet-194	307	28	29	29	NUM
admet-194	307	29	(	(	PUNCT
admet-194	307	30	2008	2008	NUM
admet-194	307	31	)	)	PUNCT
admet-194	307	32	1607	1607	NUM
admet-194	307	33	-	-	SYM
admet-194	307	34	1618	1618	NUM
admet-194	307	35	.	.	PUNCT
admet-194	308	1	[	[	X
admet-194	308	2	11	11	NUM
admet-194	308	3	]	]	PUNCT
admet-194	308	4	t.	t.	PROPN
admet-194	308	5	e.	e.	PROPN
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admet-194	308	7	,	,	PUNCT
admet-194	308	8	journal	journal	NOUN
admet-194	308	9	of	of	ADP
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admet-194	308	12	(	(	PUNCT
admet-194	308	13	2006	2006	NUM
admet-194	308	14	)	)	PUNCT
admet-194	308	15	689	689	NUM
admet-194	308	16	-	-	SYM
admet-194	308	17	707	707	NUM
admet-194	308	18	.	.	PUNCT
admet-194	309	1	[	[	X
admet-194	309	2	12	12	NUM
admet-194	309	3	]	]	X
admet-194	309	4	d.	d.	PROPN
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admet-194	309	6	,	,	PUNCT
admet-194	309	7	e.	e.	PROPN
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admet-194	309	9	,	,	PUNCT
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admet-194	309	15	4	4	NUM
admet-194	309	16	(	(	PUNCT
admet-194	309	17	2011	2011	NUM
admet-194	309	18	)	)	PUNCT
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admet-194	309	20	-	-	SYM
admet-194	309	21	216	216	NUM
admet-194	309	22	.	.	PUNCT
admet-194	310	1	[	[	X
admet-194	310	2	13	13	NUM
admet-194	310	3	]	]	PUNCT
admet-194	310	4	f.	f.	PROPN
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admet-194	310	6	,	,	PUNCT
admet-194	310	7	a.	a.	PROPN
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admet-194	310	9	,	,	PUNCT
admet-194	310	10	b.	b.	PROPN
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admet-194	310	12	,	,	PUNCT
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admet-194	310	15	,	,	PUNCT
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admet-194	310	18	,	,	PUNCT
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admet-194	310	21	9	9	NUM
admet-194	310	22	(	(	PUNCT
admet-194	310	23	2010	2010	NUM
admet-194	310	24	)	)	PUNCT
admet-194	310	25	702716	702716	NUM
admet-194	310	26	.	.	PUNCT
admet-194	311	1	[	[	X
admet-194	311	2	14	14	NUM
admet-194	311	3	]	]	PUNCT
admet-194	311	4	k.	k.	PROPN
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admet-194	311	9	,	,	PUNCT
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admet-194	311	13	4	4	NUM
admet-194	311	14	(	(	PUNCT
admet-194	311	15	2013	2013	NUM
admet-194	311	16	)	)	PUNCT
admet-194	311	17	159	159	NUM
admet-194	311	18	.	.	PUNCT
admet-194	312	1	admet	admet	PROPN
admet-194	312	2	&	&	CCONJ
admet-194	312	3	dmpk	dmpk	PROPN
admet-194	312	4	3(3	3(3	NUM
admet-194	312	5	)	)	PUNCT
admet-194	312	6	(	(	PUNCT
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admet-194	312	8	)	)	PUNCT
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admet-194	312	10	-	-	SYM
admet-194	312	11	234	234	NUM
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admet-194	313	1	[	[	X
admet-194	313	2	15	15	NUM
admet-194	313	3	]	]	X
admet-194	313	4	m.	m.	NOUN
admet-194	313	5	l.	l.	PROPN
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admet-194	313	10	,	,	PUNCT
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admet-194	313	14	,	,	PUNCT
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admet-194	313	16	z.	z.	PROPN
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admet-194	313	18	,	,	PUNCT
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admet-194	313	22	8	8	NUM
admet-194	313	23	(	(	PUNCT
admet-194	313	24	2007	2007	NUM
admet-194	313	25	)	)	PUNCT
admet-194	313	26	623	623	NUM
admet-194	313	27	-	-	SYM
admet-194	313	28	635	635	NUM
admet-194	313	29	.	.	PUNCT
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admet-194	314	2	16	16	NUM
admet-194	314	3	]	]	X
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admet-194	314	10	,	,	PUNCT
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admet-194	314	13	(	(	PUNCT
admet-194	314	14	2008	2008	NUM
admet-194	314	15	)	)	PUNCT
admet-194	314	16	3	3	NUM
admet-194	314	17	-	-	SYM
admet-194	314	18	13	13	NUM
admet-194	314	19	.	.	PUNCT
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admet-194	315	2	17	17	NUM
admet-194	315	3	]	]	PUNCT
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admet-194	315	6	,	,	PUNCT
admet-194	315	7	t.	t.	PROPN
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admet-194	315	9	,	,	PUNCT
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admet-194	315	16	(	(	PUNCT
admet-194	315	17	2006	2006	NUM
admet-194	315	18	)	)	PUNCT
admet-194	315	19	470s-474s	470s-474s	NUM
admet-194	315	20	.	.	PUNCT
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admet-194	316	2	18	18	NUM
admet-194	316	3	]	]	X
admet-194	316	4	r.	r.	PROPN
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admet-194	316	12	(	(	PUNCT
admet-194	316	13	2004	2004	NUM
admet-194	316	14	)	)	PUNCT
admet-194	316	15	105	105	NUM
admet-194	316	16	-	-	SYM
admet-194	316	17	114	114	NUM
admet-194	316	18	.	.	PUNCT
admet-194	317	1	[	[	X
admet-194	317	2	19	19	NUM
admet-194	317	3	]	]	PUNCT
admet-194	317	4	t.	t.	PROPN
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admet-194	317	11	(	(	PUNCT
admet-194	317	12	2005	2005	NUM
admet-194	317	13	)	)	PUNCT
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admet-194	317	15	-	-	SYM
admet-194	317	16	87	87	NUM
admet-194	317	17	.	.	PUNCT
admet-194	318	1	[	[	X
admet-194	318	2	20	20	NUM
admet-194	318	3	]	]	X
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admet-194	318	29	(	(	PUNCT
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admet-194	318	31	)	)	PUNCT
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admet-194	318	33	-	-	SYM
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admet-194	318	35	.	.	PUNCT
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admet-194	319	3	]	]	X
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admet-194	319	19	(	(	PUNCT
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admet-194	319	21	)	)	PUNCT
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admet-194	319	23	-	-	SYM
admet-194	319	24	489	489	NUM
admet-194	319	25	.	.	PUNCT
admet-194	320	1	[	[	X
admet-194	320	2	22	22	NUM
admet-194	320	3	]	]	PUNCT
admet-194	320	4	m.	m.	NOUN
admet-194	320	5	gold	gold	NOUN
admet-194	320	6	,	,	PUNCT
admet-194	320	7	c.	c.	PROPN
admet-194	320	8	alderton	alderton	PROPN
admet-194	320	9	,	,	PUNCT
admet-194	320	10	m.	m.	NOUN
admet-194	320	11	zvartau	zvartau	NOUN
admet-194	320	12	-	-	PUNCT
admet-194	320	13	hind	hind	NOUN
admet-194	320	14	,	,	PUNCT
admet-194	320	15	s.	s.	PROPN
admet-194	320	16	egginton	egginton	PROPN
admet-194	320	17	,	,	PUNCT
admet-194	320	18	a.m.	a.m.	PROPN
admet-194	320	19	saunders	saunder	NOUN
admet-194	320	20	,	,	PUNCT
admet-194	320	21	m.	m.	NOUN
admet-194	320	22	irizarry	irizarry	NOUN
admet-194	320	23	,	,	PUNCT
admet-194	320	24	s.	s.	PROPN
admet-194	320	25	craft	craft	PROPN
admet-194	320	26	,	,	PUNCT
admet-194	320	27	g.	g.	PROPN
admet-194	320	28	landreth	landreth	PROPN
admet-194	320	29	,	,	PUNCT
admet-194	320	30	u.	u.	PROPN
admet-194	320	31	linnamägi	linnamägi	PROPN
admet-194	320	32	,	,	PUNCT
admet-194	320	33	s.	s.	PROPN
admet-194	320	34	sawchak	sawchak	PROPN
admet-194	320	35	,	,	PUNCT
admet-194	320	36	dementia	dementia	NOUN
admet-194	320	37	and	and	CCONJ
admet-194	320	38	geriatric	geriatric	ADJ
admet-194	320	39	cognitive	cognitive	ADJ
admet-194	320	40	disorders	disorder	NOUN
admet-194	320	41	30	30	NUM
admet-194	320	42	(	(	PUNCT
admet-194	320	43	2010	2010	NUM
admet-194	320	44	)	)	PUNCT
admet-194	320	45	131	131	NUM
admet-194	320	46	-	-	SYM
admet-194	320	47	146	146	NUM
admet-194	320	48	.	.	PUNCT
admet-194	321	1	[	[	X
admet-194	321	2	23	23	NUM
admet-194	321	3	]	]	PUNCT
admet-194	321	4	t.	t.	PROPN
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admet-194	321	6	,	,	PUNCT
admet-194	321	7	h.	h.	PROPN
admet-194	321	8	hanyu	hanyu	PROPN
admet-194	321	9	,	,	PUNCT
admet-194	321	10	k.	k.	PROPN
admet-194	321	11	hirao	hirao	PROPN
admet-194	321	12	,	,	PUNCT
admet-194	321	13	h.	h.	PROPN
admet-194	321	14	kanetaka	kanetaka	PROPN
admet-194	321	15	,	,	PUNCT
admet-194	321	16	h.	h.	PROPN
admet-194	321	17	sakurai	sakurai	PROPN
admet-194	321	18	,	,	PUNCT
admet-194	321	19	t.	t.	PROPN
admet-194	321	20	iwamoto	iwamoto	NOUN
admet-194	321	21	,	,	PUNCT
admet-194	321	22	neurobiology	neurobiology	NOUN
admet-194	321	23	of	of	ADP
admet-194	321	24	aging	age	VERB
admet-194	321	25	32	32	NUM
admet-194	321	26	(	(	PUNCT
admet-194	321	27	2011	2011	NUM
admet-194	321	28	)	)	PUNCT
admet-194	321	29	1626	1626	NUM
admet-194	321	30	-	-	SYM
admet-194	321	31	1633	1633	NUM
admet-194	321	32	.	.	PUNCT
admet-194	322	1	[	[	X
admet-194	322	2	24	24	NUM
admet-194	322	3	]	]	X
admet-194	322	4	d.	d.	PROPN
admet-194	322	5	s.	s.	PROPN
admet-194	322	6	geldmacher	geldmacher	PROPN
admet-194	322	7	,	,	PUNCT
admet-194	322	8	t.	t.	PROPN
admet-194	322	9	fritsch	fritsch	PROPN
admet-194	322	10	,	,	PUNCT
admet-194	322	11	m.	m.	PROPN
admet-194	322	12	j.	j.	PROPN
admet-194	322	13	mcclendon	mcclendon	PROPN
admet-194	322	14	,	,	PUNCT
admet-194	322	15	g.	g.	PROPN
admet-194	322	16	landreth	landreth	PROPN
admet-194	322	17	,	,	PUNCT
admet-194	322	18	archives	archive	NOUN
admet-194	322	19	of	of	ADP
admet-194	322	20	neurology	neurology	NOUN
admet-194	322	21	68	68	NUM
admet-194	322	22	(	(	PUNCT
admet-194	322	23	2011	2011	NUM
admet-194	322	24	)	)	PUNCT
admet-194	322	25	45	45	NUM
admet-194	322	26	-	-	SYM
admet-194	322	27	50	50	NUM
admet-194	322	28	.	.	PUNCT
admet-194	323	1	[	[	X
admet-194	323	2	25	25	NUM
admet-194	323	3	]	]	PUNCT
admet-194	323	4	biomarker	biomarker	NOUN
admet-194	323	5	qualification	qualification	NOUN
admet-194	323	6	for	for	ADP
admet-194	323	7	risk	risk	NOUN
admet-194	323	8	of	of	ADP
admet-194	323	9	mild	mild	ADJ
admet-194	323	10	cognitive	cognitive	ADJ
admet-194	323	11	impairment	impairment	NOUN
admet-194	323	12	(	(	PUNCT
admet-194	323	13	mci	mci	NOUN
admet-194	323	14	)	)	PUNCT
admet-194	323	15	due	due	ADP
admet-194	323	16	to	to	ADP
admet-194	323	17	alzheimer	alzheimer	PROPN
admet-194	323	18	's	's	PART
admet-194	323	19	disease	disease	NOUN
admet-194	323	20	(	(	PUNCT
admet-194	323	21	ad	ad	NOUN
admet-194	323	22	)	)	PUNCT
admet-194	323	23	and	and	CCONJ
admet-194	323	24	safety	safety	NOUN
admet-194	323	25	and	and	CCONJ
admet-194	323	26	efficacy	efficacy	NOUN
admet-194	323	27	evaluation	evaluation	NOUN
admet-194	323	28	of	of	ADP
admet-194	323	29	pioglitazone	pioglitazone	NOUN
admet-194	323	30	in	in	ADP
admet-194	323	31	delaying	delay	VERB
admet-194	323	32	its	its	PRON
admet-194	323	33	onset	onset	NOUN
admet-194	323	34	,	,	PUNCT
admet-194	323	35	https://www.clinicaltrials.gov/ct2/show/nct01931566?term=pioglitazone%2c+alzheimer&rank=1	https://www.clinicaltrials.gov/ct2/show/nct01931566?term=pioglitazone%2c+alzheimer&rank=1	PROPN
admet-194	323	36	(	(	PUNCT
admet-194	323	37	october	october	PROPN
admet-194	323	38	2014	2014	NUM
admet-194	323	39	)	)	PUNCT
admet-194	323	40	.	.	PUNCT
admet-194	324	1	[	[	X
admet-194	324	2	26	26	NUM
admet-194	324	3	]	]	PUNCT
admet-194	324	4	j.	j.	PROPN
admet-194	324	5	hey	hey	PROPN
admet-194	324	6	,	,	PUNCT
admet-194	324	7	g.	g.	PROPN
admet-194	324	8	koelsch	koelsch	PROPN
admet-194	324	9	,	,	PUNCT
admet-194	324	10	g.	g.	PROPN
admet-194	324	11	bilcer	bilcer	PROPN
admet-194	324	12	,	,	PUNCT
admet-194	324	13	a.	a.	PROPN
admet-194	324	14	jacobs	jacobs	PROPN
admet-194	324	15	,	,	PUNCT
admet-194	324	16	m.	m.	PROPN
admet-194	324	17	tolar	tolar	PROPN
admet-194	324	18	,	,	PUNCT
admet-194	324	19	j.	j.	PROPN
admet-194	324	20	tang	tang	PROPN
admet-194	324	21	,	,	PUNCT
admet-194	324	22	international	international	ADJ
admet-194	324	23	conference	conference	NOUN
admet-194	324	24	on	on	ADP
admet-194	324	25	alzheimer	alzheimer	PROPN
admet-194	324	26	's	's	PART
admet-194	324	27	disease	disease	NOUN
admet-194	324	28	(	(	PUNCT
admet-194	324	29	icad	icad	PROPN
admet-194	324	30	)	)	PUNCT
admet-194	324	31	,	,	PUNCT
admet-194	324	32	chicago	chicago	PROPN
admet-194	324	33	,	,	PUNCT
admet-194	324	34	il	il	PROPN
admet-194	324	35	,	,	PUNCT
admet-194	324	36	usa	usa	PROPN
admet-194	324	37	(	(	PUNCT
admet-194	324	38	2008	2008	NUM
admet-194	324	39	)	)	PUNCT
admet-194	324	40	26	26	NUM
admet-194	324	41	-	-	SYM
admet-194	324	42	31	31	NUM
admet-194	324	43	.	.	PUNCT
admet-194	325	1	[	[	X
admet-194	325	2	27	27	NUM
admet-194	325	3	]	]	X
admet-194	325	4	i.	i.	PROPN
admet-194	325	5	hussain	hussain	PROPN
admet-194	325	6	,	,	PUNCT
admet-194	325	7	j.	j.	PROPN
admet-194	325	8	hawkins	hawkins	PROPN
admet-194	325	9	,	,	PUNCT
admet-194	325	10	d.	d.	PROPN
admet-194	325	11	harrison	harrison	PROPN
admet-194	325	12	,	,	PUNCT
admet-194	325	13	c.	c.	PROPN
admet-194	325	14	hille	hille	PROPN
admet-194	325	15	,	,	PUNCT
admet-194	325	16	g.	g.	PROPN
admet-194	325	17	wayne	wayne	PROPN
admet-194	325	18	,	,	PUNCT
admet-194	325	19	l.	l.	PROPN
admet-194	325	20	cutler	cutler	PROPN
admet-194	325	21	,	,	PUNCT
admet-194	325	22	t.	t.	NOUN
admet-194	325	23	buck	buck	PROPN
admet-194	325	24	,	,	PUNCT
admet-194	325	25	d.	d.	PROPN
admet-194	325	26	walter	walter	PROPN
admet-194	325	27	,	,	PUNCT
admet-194	325	28	e.	e.	PROPN
admet-194	325	29	demont	demont	PROPN
admet-194	325	30	,	,	PUNCT
admet-194	325	31	c.	c.	PROPN
admet-194	325	32	howes	howes	PROPN
admet-194	325	33	,	,	PUNCT
admet-194	325	34	a.	a.	PROPN
admet-194	325	35	naylor	naylor	PROPN
admet-194	325	36	,	,	PUNCT
admet-194	325	37	p.	p.	PROPN
admet-194	325	38	jeffrey	jeffrey	PROPN
admet-194	325	39	,	,	PUNCT
admet-194	325	40	m.i	m.i	PROPN
admet-194	325	41	.	.	PROPN
admet-194	325	42	gonzalez	gonzalez	PROPN
admet-194	325	43	,	,	PUNCT
admet-194	325	44	c.	c.	PROPN
admet-194	325	45	dingwall	dingwall	PROPN
admet-194	325	46	,	,	PUNCT
admet-194	325	47	a.	a.	PROPN
admet-194	325	48	michel	michel	PROPN
admet-194	325	49	,	,	PUNCT
admet-194	325	50	s.	s.	PROPN
admet-194	325	51	redshaw	redshaw	PROPN
admet-194	325	52	,	,	PUNCT
admet-194	325	53	j.b	j.b	PROPN
admet-194	325	54	.	.	PUNCT
admet-194	325	55	davis	davis	PROPN
admet-194	325	56	,	,	PUNCT
admet-194	325	57	journal	journal	NOUN
admet-194	325	58	of	of	ADP
admet-194	325	59	neurochemistry	neurochemistry	NOUN
admet-194	325	60	100	100	NUM
admet-194	325	61	(	(	PUNCT
admet-194	325	62	2007	2007	NUM
admet-194	325	63	)	)	PUNCT
admet-194	325	64	802	802	NUM
admet-194	325	65	-	-	SYM
admet-194	325	66	809	809	NUM
admet-194	325	67	.	.	PUNCT
admet-194	326	1	[	[	X
admet-194	326	2	28	28	NUM
admet-194	326	3	]	]	X
admet-194	326	4	j.	j.	PROPN
admet-194	326	5	li	li	PROPN
admet-194	326	6	,	,	PUNCT
admet-194	326	7	j.	j.	PROPN
admet-194	326	8	hu	hu	PROPN
admet-194	326	9	,	,	PUNCT
admet-194	326	10	b.	b.	PROPN
admet-194	326	11	shao	shao	PROPN
admet-194	326	12	,	,	PUNCT
admet-194	326	13	w.	w.	PROPN
admet-194	326	14	zhou	zhou	PROPN
admet-194	326	15	,	,	PUNCT
admet-194	326	16	y.	y.	PROPN
admet-194	326	17	cui	cui	PROPN
admet-194	326	18	,	,	PUNCT
admet-194	326	19	c.	c.	PROPN
admet-194	326	20	dong	dong	PROPN
admet-194	326	21	,	,	PUNCT
admet-194	326	22	j.m	j.m	PROPN
admet-194	326	23	.	.	PROPN
admet-194	326	24	ezoulin	ezoulin	PROPN
admet-194	326	25	,	,	PUNCT
admet-194	326	26	x.	x.	PROPN
admet-194	326	27	zhu	zhu	PROPN
admet-194	326	28	,	,	PUNCT
admet-194	326	29	w.	w.	PROPN
admet-194	326	30	ding	ding	PROPN
admet-194	326	31	,	,	PUNCT
admet-194	326	32	f.	f.	PROPN
admet-194	326	33	heymans	heymans	PROPN
admet-194	326	34	,	,	PUNCT
admet-194	326	35	h.	h.	PROPN
admet-194	326	36	chen	chen	PROPN
admet-194	326	37	,	,	PUNCT
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admet-194	326	39	and	and	CCONJ
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admet-194	326	41	neurobiology	neurobiology	NOUN
admet-194	326	42	29	29	NUM
admet-194	326	43	(	(	PUNCT
admet-194	326	44	2009	2009	NUM
admet-194	326	45	)	)	PUNCT
admet-194	326	46	589	589	NUM
admet-194	326	47	-	-	SYM
admet-194	326	48	595	595	NUM
admet-194	326	49	.	.	PUNCT
admet-194	327	1	[	[	X
admet-194	327	2	29	29	NUM
admet-194	327	3	]	]	PUNCT
admet-194	327	4	a.	a.	PROPN
admet-194	327	5	k.	k.	PROPN
admet-194	327	6	ghosh	ghosh	PROPN
admet-194	327	7	,	,	PUNCT
admet-194	327	8	m.	m.	NOUN
admet-194	327	9	brindisi	brindisi	PROPN
admet-194	327	10	,	,	PUNCT
admet-194	327	11	j.	j.	PROPN
admet-194	327	12	tang	tang	PROPN
admet-194	327	13	,	,	PUNCT
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admet-194	327	16	neurochemistry	neurochemistry	NOUN
admet-194	327	17	120	120	NUM
admet-194	327	18	suppl	suppl	ADJ
admet-194	327	19	1	1	NUM
admet-194	327	20	(	(	PUNCT
admet-194	327	21	2012	2012	NUM
admet-194	327	22	)	)	PUNCT
admet-194	327	23	71	71	NUM
admet-194	327	24	-	-	SYM
admet-194	327	25	83	83	NUM
admet-194	327	26	.	.	PUNCT
admet-194	328	1	[	[	X
admet-194	328	2	30	30	NUM
admet-194	328	3	]	]	X
admet-194	328	4	g.t	g.t	PROPN
admet-194	328	5	.	.	PROPN
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admet-194	328	7	,	,	PUNCT
admet-194	328	8	d.	d.	PROPN
admet-194	328	9	manfra	manfra	PROPN
admet-194	328	10	,	,	PUNCT
admet-194	328	11	f.m	f.m	PROPN
admet-194	328	12	.	.	PROPN
admet-194	328	13	poulet	poulet	PROPN
admet-194	328	14	,	,	PUNCT
admet-194	328	15	q.	q.	PROPN
admet-194	328	16	zhang	zhang	PROPN
admet-194	328	17	,	,	PUNCT
admet-194	328	18	h.	h.	PROPN
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admet-194	328	20	,	,	PUNCT
admet-194	328	21	t.	t.	PROPN
admet-194	328	22	bara	bara	PROPN
admet-194	328	23	,	,	PUNCT
admet-194	328	24	l.	l.	PROPN
admet-194	328	25	engstrom	engstrom	PROPN
admet-194	328	26	,	,	PUNCT
admet-194	328	27	m.	m.	NOUN
admet-194	328	28	pinzon	pinzon	PROPN
admet-194	328	29	-	-	PUNCT
admet-194	328	30	ortiz	ortiz	PROPN
admet-194	328	31	,	,	PUNCT
admet-194	328	32	j.s	j.s	PROPN
admet-194	328	33	.	.	PROPN
admet-194	328	34	fine	fine	PROPN
admet-194	328	35	,	,	PUNCT
admet-194	328	36	h.j.j	h.j.j	PROPN
admet-194	328	37	.	.	PROPN
admet-194	328	38	lee	lee	PROPN
admet-194	328	39	,	,	PUNCT
admet-194	328	40	l.	l.	PROPN
admet-194	328	41	zhang	zhang	PROPN
admet-194	328	42	,	,	PUNCT
admet-194	328	43	g.a	g.a	PROPN
admet-194	328	44	.	.	PROPN
admet-194	328	45	higgins	higgins	PROPN
admet-194	328	46	,	,	PUNCT
admet-194	328	47	e.m	e.m	PROPN
admet-194	328	48	.	.	PROPN
admet-194	328	49	parker	parker	PROPN
admet-194	328	50	,	,	PUNCT
admet-194	328	51	journal	journal	NOUN
admet-194	328	52	of	of	ADP
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admet-194	328	54	chemistry	chemistry	NOUN
admet-194	328	55	279	279	NUM
admet-194	328	56	(	(	PUNCT
admet-194	328	57	2004	2004	NUM
admet-194	328	58	)	)	PUNCT
admet-194	328	59	1287612882	1287612882	NUM
admet-194	328	60	.	.	PUNCT
admet-194	329	1	[	[	X
admet-194	329	2	31	31	NUM
admet-194	329	3	]	]	X
admet-194	329	4	r.s	r.s	PROPN
admet-194	329	5	.	.	PROPN
admet-194	329	6	doody	doody	PROPN
admet-194	329	7	,	,	PUNCT
admet-194	329	8	r.	r.	PROPN
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admet-194	329	10	,	,	PUNCT
admet-194	329	11	m.	m.	NOUN
admet-194	329	12	farlow	farlow	NOUN
admet-194	329	13	,	,	PUNCT
admet-194	329	14	t.	t.	PROPN
admet-194	329	15	iwatsubo	iwatsubo	PROPN
admet-194	329	16	,	,	PUNCT
admet-194	329	17	b.	b.	PROPN
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admet-194	329	20	s.	s.	PROPN
admet-194	329	21	joffe	joffe	PROPN
admet-194	329	22	,	,	PUNCT
admet-194	329	23	k.	k.	PROPN
admet-194	329	24	kieburtz	kieburtz	PROPN
admet-194	329	25	,	,	PUNCT
admet-194	329	26	f.	f.	PROPN
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admet-194	329	29	x.	x.	PROPN
admet-194	329	30	sun	sun	PROPN
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admet-194	329	36	p.s	p.s	PROPN
admet-194	329	37	.	.	PROPN
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admet-194	329	39	;	;	PUNCT
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admet-194	329	43	cooperative	cooperative	ADJ
admet-194	329	44	study	study	NOUN
admet-194	329	45	steering	steering	NOUN
admet-194	329	46	committee	committee	NOUN
admet-194	329	47	,	,	PUNCT
admet-194	329	48	e.	e.	PROPN
admet-194	329	49	siemers	siemers	PROPN
admet-194	329	50	,	,	PUNCT
admet-194	329	51	g.	g.	PROPN
admet-194	329	52	sethuraman	sethuraman	PROPN
admet-194	329	53	,	,	PUNCT
admet-194	329	54	r.	r.	PROPN
admet-194	329	55	mohs	mohs	PROPN
admet-194	329	56	;	;	PUNCT
admet-194	329	57	semagacestat	semagacestat	PROPN
admet-194	329	58	study	study	NOUN
admet-194	329	59	group	group	NOUN
admet-194	329	60	,	,	PUNCT
admet-194	329	61	new	new	PROPN
admet-194	329	62	england	england	PROPN
admet-194	329	63	journal	journal	PROPN
admet-194	329	64	of	of	ADP
admet-194	329	65	medicine	medicine	PROPN
admet-194	329	66	369	369	NUM
admet-194	329	67	(	(	PUNCT
admet-194	329	68	2013	2013	NUM
admet-194	329	69	)	)	PUNCT
admet-194	329	70	341350	341350	NUM
admet-194	329	71	.	.	PUNCT
admet-194	330	1	[	[	X
admet-194	330	2	32	32	NUM
admet-194	330	3	]	]	PUNCT
admet-194	330	4	r.	r.	PROPN
admet-194	330	5	n.	n.	PROPN
admet-194	330	6	soares	soares	PROPN
admet-194	330	7	h	h	PROPN
admet-194	330	8	,	,	PUNCT
admet-194	330	9	sikpi	sikpi	PROPN
admet-194	330	10	m	m	PROPN
admet-194	330	11	,	,	PUNCT
admet-194	330	12	et	et	PROPN
admet-194	330	13	al	al	PROPN
admet-194	330	14	.	.	PROPN
admet-194	330	15	,	,	PUNCT
admet-194	330	16	alzheimer	alzheimer	PROPN
admet-194	330	17	’s	’s	PART
admet-194	330	18	&	&	CCONJ
admet-194	330	19	dementia	dementia	PROPN
admet-194	330	20	5	5	NUM
admet-194	330	21	(	(	PUNCT
admet-194	330	22	2009	2009	NUM
admet-194	330	23	)	)	PUNCT
admet-194	330	24	252	252	NUM
admet-194	330	25	.	.	PUNCT
admet-194	331	1	[	[	X
admet-194	331	2	33	33	NUM
admet-194	331	3	]	]	PUNCT
admet-194	331	4	v.	v.	CCONJ
admet-194	331	5	ćorić	ćorić	ADJ
admet-194	331	6	,	,	PUNCT
admet-194	331	7	c.h	c.h	PROPN
admet-194	331	8	.	.	PROPN
admet-194	331	9	van	van	PROPN
admet-194	331	10	dyck	dyck	PROPN
admet-194	331	11	,	,	PUNCT
admet-194	331	12	s.	s.	PROPN
admet-194	331	13	salloway	salloway	PROPN
admet-194	331	14	,	,	PUNCT
admet-194	331	15	n.	n.	NOUN
admet-194	331	16	andreasen	andreasen	PROPN
admet-194	331	17	,	,	PUNCT
admet-194	331	18	m.	m.	NOUN
admet-194	331	19	brody	brody	PROPN
admet-194	331	20	,	,	PUNCT
admet-194	331	21	r.w	r.w	PROPN
admet-194	331	22	.	.	PROPN
admet-194	331	23	richter	richter	PROPN
admet-194	331	24	,	,	PUNCT
admet-194	331	25	h.	h.	PROPN
admet-194	331	26	soininen	soininen	PROPN
admet-194	331	27	,	,	PUNCT
admet-194	331	28	s.	s.	PROPN
admet-194	331	29	thein	thein	PROPN
admet-194	331	30	,	,	PUNCT
admet-194	331	31	t.	t.	PROPN
admet-194	331	32	shiovitz	shiovitz	PROPN
admet-194	331	33	,	,	PUNCT
admet-194	331	34	g.	g.	PROPN
admet-194	331	35	pilcher	pilcher	PROPN
admet-194	331	36	,	,	PUNCT
admet-194	331	37	s.	s.	PROPN
admet-194	331	38	colby	colby	PROPN
admet-194	331	39	,	,	PUNCT
admet-194	331	40	l.	l.	PROPN
admet-194	331	41	rollin	rollin	PROPN
admet-194	331	42	,	,	PUNCT
admet-194	331	43	r.	r.	PROPN
admet-194	331	44	dockens	dockens	PROPN
admet-194	331	45	,	,	PUNCT
admet-194	331	46	c.	c.	PROPN
admet-194	331	47	pachai	pachai	PROPN
admet-194	331	48	,	,	PUNCT
admet-194	331	49	e.	e.	PROPN
admet-194	331	50	portelius	portelius	PROPN
admet-194	331	51	,	,	PUNCT
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admet-194	331	54	,	,	PUNCT
admet-194	331	55	k.	k.	PROPN
admet-194	331	56	blennow	blennow	PROPN
admet-194	331	57	,	,	PUNCT
admet-194	331	58	h.	h.	PROPN
admet-194	331	59	soares	soares	PROPN
admet-194	331	60	,	,	PUNCT
admet-194	331	61	c.	c.	PROPN
admet-194	331	62	albright	albright	PROPN
admet-194	331	63	,	,	PUNCT
admet-194	331	64	h.h	h.h	PROPN
admet-194	331	65	.	.	PROPN
admet-194	331	66	feldman	feldman	PROPN
admet-194	331	67	,	,	PUNCT
admet-194	331	68	r.m	r.m	PROPN
admet-194	331	69	.	.	PROPN
admet-194	331	70	berman	berman	PROPN
admet-194	331	71	,	,	PUNCT
admet-194	331	72	archive	archive	NOUN
admet-194	331	73	of	of	ADP
admet-194	331	74	neurology	neurology	NOUN
admet-194	331	75	69	69	NUM
admet-194	331	76	(	(	PUNCT
admet-194	331	77	2012	2012	NUM
admet-194	331	78	)	)	PUNCT
admet-194	331	79	1430	1430	NUM
admet-194	331	80	-	-	SYM
admet-194	331	81	1440	1440	NUM
admet-194	331	82	.	.	PUNCT
admet-194	332	1	[	[	X
admet-194	332	2	34	34	NUM
admet-194	332	3	]	]	X
admet-194	332	4	r.l	r.l	PROPN
admet-194	332	5	.	.	PROPN
admet-194	332	6	martone	martone	PROPN
admet-194	332	7	,	,	PUNCT
admet-194	332	8	h.	h.	PROPN
admet-194	332	9	,	,	PUNCT
admet-194	332	10	zhou	zhou	PROPN
admet-194	332	11	,	,	PUNCT
admet-194	332	12	k.	k.	PROPN
admet-194	332	13	atchison	atchison	PROPN
admet-194	332	14	,	,	PUNCT
admet-194	332	15	t.	t.	NOUN
admet-194	332	16	comery	comery	PROPN
admet-194	332	17	,	,	PUNCT
admet-194	332	18	j.z	j.z	PROPN
admet-194	332	19	.	.	PROPN
admet-194	332	20	xu	xu	PROPN
admet-194	332	21	,	,	PUNCT
admet-194	332	22	x.	x.	PROPN
admet-194	332	23	huang	huang	PROPN
admet-194	332	24	,	,	PUNCT
admet-194	332	25	x.	x.	PROPN
admet-194	332	26	gong	gong	PROPN
admet-194	332	27	,	,	PUNCT
admet-194	332	28	m.	m.	NOUN
admet-194	332	29	jin	jin	PROPN
admet-194	332	30	,	,	PUNCT
admet-194	332	31	a.	a.	PROPN
admet-194	332	32	kreft	kreft	PROPN
admet-194	332	33	,	,	PUNCT
admet-194	332	34	b.	b.	PROPN
admet-194	332	35	harrison	harrison	PROPN
admet-194	332	36	,	,	PUNCT
admet-194	332	37	s.c	s.c	PROPN
admet-194	332	38	.	.	PROPN
admet-194	332	39	mayer	mayer	PROPN
admet-194	332	40	,	,	PUNCT
admet-194	332	41	s.	s.	PROPN
admet-194	332	42	aschmies	aschmies	PROPN
admet-194	332	43	,	,	PUNCT
admet-194	332	44	c.	c.	PROPN
admet-194	332	45	gonzales	gonzales	PROPN
admet-194	332	46	,	,	PUNCT
admet-194	332	47	m.m	m.m	PROPN
admet-194	332	48	.	.	PROPN
admet-194	332	49	zaleska	zaleska	PROPN
admet-194	332	50	,	,	PUNCT
admet-194	332	51	d.r	d.r	PROPN
admet-194	332	52	.	.	PROPN
admet-194	332	53	riddell	riddell	PROPN
admet-194	332	54	,	,	PUNCT
admet-194	332	55	e.	e.	PROPN
admet-194	332	56	wagner	wagner	PROPN
admet-194	332	57	,	,	PUNCT
admet-194	332	58	p.	p.	PROPN
admet-194	332	59	lu	lu	PROPN
admet-194	332	60	,	,	PUNCT
admet-194	332	61	s.c	s.c	PROPN
admet-194	332	62	.	.	PROPN
admet-194	332	63	sun	sun	PROPN
admet-194	332	64	,	,	PUNCT
admet-194	332	65	j.	j.	PROPN
admet-194	332	66	sonnenberg	sonnenberg	PROPN
admet-194	332	67	-	-	PUNCT
admet-194	332	68	reines	reines	PROPN
admet-194	332	69	,	,	PUNCT
admet-194	332	70	a.	a.	NOUN
admet-194	332	71	oganesian	oganesian	PROPN
admet-194	332	72	,	,	PUNCT
admet-194	332	73	k.	k.	PROPN
admet-194	332	74	adkins	adkins	PROPN
admet-194	332	75	,	,	PUNCT
admet-194	332	76	m.w	m.w	PROPN
admet-194	332	77	.	.	PROPN
admet-194	332	78	leach	leach	NOUN
admet-194	332	79	,	,	PUNCT
admet-194	332	80	d.w	d.w	PROPN
admet-194	332	81	.	.	PROPN
admet-194	332	82	clarke	clarke	PROPN
admet-194	332	83	,	,	PUNCT
admet-194	332	84	d.	d.	PROPN
admet-194	332	85	huryn	huryn	PROPN
admet-194	332	86	,	,	PUNCT
admet-194	332	87	m.	m.	PROPN
admet-194	332	88	abou	abou	PROPN
admet-194	332	89	-	-	PUNCT
admet-194	332	90	gharbia	gharbia	PROPN
admet-194	332	91	,	,	PUNCT
admet-194	332	92	r.	r.	PROPN
admet-194	332	93	magolda	magolda	PROPN
admet-194	332	94	,	,	PUNCT
admet-194	332	95	j.	j.	PROPN
admet-194	332	96	bard	bard	PROPN
admet-194	332	97	,	,	PUNCT
admet-194	332	98	g.	g.	PROPN
admet-194	332	99	frick	frick	PROPN
admet-194	332	100	,	,	PUNCT
admet-194	332	101	s.	s.	PROPN
admet-194	332	102	raje	raje	PROPN
admet-194	332	103	,	,	PUNCT
admet-194	332	104	s.b	s.b	PROPN
admet-194	332	105	.	.	PROPN
admet-194	332	106	forlow	forlow	PROPN
admet-194	332	107	,	,	PUNCT
admet-194	332	108	c.	c.	PROPN
admet-194	332	109	balliet	balliet	PROPN
admet-194	332	110	,	,	PUNCT
admet-194	332	111	m.e	m.e	PROPN
admet-194	332	112	.	.	PROPN
admet-194	332	113	burczynski	burczynski	PROPN
admet-194	332	114	,	,	PUNCT
admet-194	332	115	p.h	p.h	PROPN
admet-194	332	116	.	.	PROPN
admet-194	332	117	reinhart	reinhart	PROPN
admet-194	332	118	,	,	PUNCT
admet-194	332	119	h.i	h.i	PROPN
admet-194	332	120	.	.	PROPN
admet-194	332	121	wan	wan	PROPN
admet-194	332	122	,	,	PUNCT
admet-194	332	123	m.n	m.n	PROPN
admet-194	332	124	.	.	PROPN
admet-194	332	125	pangalos	pangalos	PROPN
admet-194	332	126	,	,	PUNCT
admet-194	332	127	j.s	j.s	PROPN
admet-194	332	128	.	.	PROPN
admet-194	332	129	jacobsen	jacobsen	PROPN
admet-194	332	130	,	,	PUNCT
admet-194	332	131	journal	journal	NOUN
admet-194	332	132	of	of	ADP
admet-194	332	133	pharmacology	pharmacology	NOUN
admet-194	332	134	and	and	CCONJ
admet-194	332	135	experimental	experimental	ADJ
admet-194	332	136	therapeutics	therapeutic	NOUN
admet-194	332	137	331	331	NUM
admet-194	332	138	(	(	PUNCT
admet-194	332	139	2009	2009	NUM
admet-194	332	140	)	)	PUNCT
admet-194	332	141	598	598	NUM
admet-194	332	142	-	-	SYM
admet-194	332	143	608	608	NUM
admet-194	332	144	.	.	PUNCT
admet-194	333	1	[	[	X
admet-194	333	2	35	35	NUM
admet-194	333	3	]	]	PUNCT
admet-194	333	4	m.	m.	NOUN
admet-194	333	5	g.	g.	PROPN
admet-194	333	6	grossman	grossman	PROPN
admet-194	333	7	h	h	PROPN
admet-194	333	8	,	,	PUNCT
admet-194	333	9	luo	luo	PROPN
admet-194	333	10	x	x	PROPN
admet-194	333	11	,	,	PUNCT
admet-194	333	12	leroith	leroith	PROPN
admet-194	333	13	d	d	PROPN
admet-194	333	14	,	,	PUNCT
admet-194	333	15	sano	sano	PROPN
admet-194	333	16	m	m	PROPN
admet-194	333	17	,	,	PUNCT
admet-194	333	18	pasinetti	pasinetti	VERB
admet-194	333	19	g	g	PROPN
admet-194	333	20	,	,	PUNCT
admet-194	333	21	alzheimer	alzheimer	PROPN
admet-194	333	22	’s	’s	NOUN
admet-194	333	23	&	&	CCONJ
admet-194	333	24	dementia	dementia	PROPN
admet-194	333	25	5	5	NUM
admet-194	333	26	(	(	PUNCT
admet-194	333	27	2009	2009	NUM
admet-194	333	28	)	)	PUNCT
admet-194	333	29	259	259	NUM
admet-194	333	30	.	.	PUNCT
admet-194	334	1	[	[	X
admet-194	334	2	36	36	NUM
admet-194	334	3	]	]	PUNCT
admet-194	334	4	a	a	DET
admet-194	334	5	single	single	ADJ
admet-194	334	6	site	site	NOUN
admet-194	334	7	,	,	PUNCT
admet-194	334	8	randomized	randomize	VERB
admet-194	334	9	,	,	PUNCT
admet-194	334	10	double	double	ADJ
admet-194	334	11	-	-	PUNCT
admet-194	334	12	blind	blind	ADJ
admet-194	334	13	,	,	PUNCT
admet-194	334	14	placebo	placebo	NOUN
admet-194	334	15	controlled	control	VERB
admet-194	334	16	trial	trial	NOUN
admet-194	334	17	of	of	ADP
admet-194	334	18	nic5	nic5	NOUN
admet-194	334	19	-	-	PUNCT
admet-194	334	20	15	15	NUM
admet-194	334	21	in	in	ADP
admet-194	334	22	subjects	subject	NOUN
admet-194	334	23	with	with	ADP
admet-194	334	24	alzheimer	alzheimer	PROPN
admet-194	334	25	's	's	PART
admet-194	334	26	disease	disease	NOUN
admet-194	334	27	,	,	PUNCT
admet-194	334	28	https://clinicaltrials.gov/ct2/show/record/nct01928420?term=nic5-15&rank=1	https://clinicaltrials.gov/ct2/show/record/nct01928420?term=nic5-15&rank=1	PROPN
admet-194	334	29	(	(	PUNCT
admet-194	334	30	august	august	PROPN
admet-194	334	31	2013	2013	NUM
admet-194	334	32	)	)	PUNCT
admet-194	334	33	.	.	PUNCT
admet-194	335	1	[	[	X
admet-194	335	2	37	37	NUM
admet-194	335	3	]	]	PUNCT
admet-194	335	4	t.	t.	PROPN
admet-194	335	5	tomita	tomita	PROPN
admet-194	335	6	,	,	PUNCT
admet-194	335	7	expert	expert	NOUN
admet-194	335	8	review	review	NOUN
admet-194	335	9	of	of	ADP
admet-194	335	10	neurotherapeutics	neurotherapeutic	NOUN
admet-194	335	11	9	9	NUM
admet-194	335	12	(	(	PUNCT
admet-194	335	13	2009	2009	NUM
admet-194	335	14	)	)	PUNCT
admet-194	335	15	661	661	NUM
admet-194	335	16	-	-	SYM
admet-194	335	17	679	679	NUM
admet-194	335	18	.	.	PUNCT
admet-194	336	1	[	[	X
admet-194	336	2	38	38	NUM
admet-194	336	3	]	]	X
admet-194	336	4	r.c	r.c	PROPN
admet-194	336	5	.	.	PROPN
admet-194	336	6	green	green	PROPN
admet-194	336	7	,	,	PUNCT
admet-194	336	8	l.s	l.s	PROPN
admet-194	336	9	.	.	PROPN
admet-194	336	10	schneider	schneider	PROPN
admet-194	336	11	,	,	PUNCT
admet-194	336	12	d.a	d.a	PROPN
admet-194	336	13	.	.	PROPN
admet-194	336	14	amato	amato	PROPN
admet-194	336	15	,	,	PUNCT
admet-194	336	16	a.p	a.p	PROPN
admet-194	336	17	.	.	PROPN
admet-194	336	18	beelen	beelen	PROPN
admet-194	336	19	,	,	PUNCT
admet-194	336	20	g.	g.	PROPN
admet-194	336	21	wilcock	wilcock	PROPN
admet-194	336	22	,	,	PUNCT
admet-194	336	23	e.a	e.a	PROPN
admet-194	336	24	.	.	PROPN
admet-194	336	25	swabb	swabb	PROPN
admet-194	336	26	,	,	PUNCT
admet-194	336	27	k.h	k.h	PROPN
admet-194	336	28	.	.	PROPN
admet-194	336	29	zavitz	zavitz	PROPN
admet-194	336	30	,	,	PUNCT
admet-194	336	31	journal	journal	NOUN
admet-194	336	32	of	of	ADP
admet-194	336	33	the	the	DET
admet-194	336	34	american	american	PROPN
admet-194	336	35	medical	medical	PROPN
admet-194	336	36	association	association	PROPN
admet-194	336	37	302	302	NUM
admet-194	336	38	(	(	PUNCT
admet-194	336	39	2009	2009	NUM
admet-194	336	40	)	)	PUNCT
admet-194	336	41	2557	2557	NUM
admet-194	336	42	-	-	SYM
admet-194	336	43	2564	2564	NUM
admet-194	336	44	.	.	PUNCT
admet-194	337	1	https://www.clinicaltrials.gov/ct2/show/nct01931566?term=pioglitazone%2c+alzheimer&rank=1	https://www.clinicaltrials.gov/ct2/show/nct01931566?term=pioglitazone%2c+alzheimer&rank=1	PROPN
admet-194	337	2	https://clinicaltrials.gov/ct2/show/record/nct01928420?term=nic5-15&rank=1	https://clinicaltrials.gov/ct2/show/record/nct01928420?term=nic5-15&rank=1	PROPN
admet-194	337	3	jing	jing	PROPN
admet-194	337	4	li	li	PROPN
admet-194	337	5	et	et	PROPN
admet-194	337	6	al	al	PROPN
admet-194	337	7	.	.	PROPN
admet-194	337	8	admet	admet	PROPN
admet-194	337	9	&	&	CCONJ
admet-194	337	10	dmpk	dmpk	PROPN
admet-194	337	11	3(3	3(3	NUM
admet-194	337	12	)	)	PUNCT
admet-194	337	13	(	(	PUNCT
admet-194	337	14	2015	2015	NUM
admet-194	337	15	)	)	PUNCT
admet-194	337	16	216	216	NUM
admet-194	337	17	-	-	SYM
admet-194	337	18	234	234	NUM
admet-194	337	19	230	230	NUM
admet-194	337	20	[	[	SYM
admet-194	337	21	39	39	NUM
admet-194	337	22	]	]	PUNCT
admet-194	337	23	j.	j.	PROPN
admet-194	337	24	ross	ross	PROPN
admet-194	337	25	,	,	PUNCT
admet-194	337	26	s.	s.	PROPN
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admet-194	337	28	,	,	PUNCT
admet-194	337	29	j.	j.	PROPN
admet-194	337	30	winston	winston	PROPN
admet-194	337	31	,	,	PUNCT
admet-194	337	32	m.	m.	PROPN
admet-194	337	33	nunez	nunez	PROPN
admet-194	337	34	,	,	PUNCT
admet-194	337	35	g.	g.	PROPN
admet-194	337	36	bottini	bottini	PROPN
admet-194	337	37	,	,	PUNCT
admet-194	337	38	m.	m.	NOUN
admet-194	337	39	franceschi	franceschi	PROPN
admet-194	337	40	,	,	PUNCT
admet-194	337	41	e.	e.	PROPN
admet-194	337	42	scarpini	scarpini	PROPN
admet-194	337	43	,	,	PUNCT
admet-194	337	44	e.	e.	PROPN
admet-194	337	45	frigerio	frigerio	PROPN
admet-194	337	46	,	,	PUNCT
admet-194	337	47	f.	f.	PROPN
admet-194	337	48	fiorentini	fiorentini	PROPN
admet-194	337	49	,	,	PUNCT
admet-194	337	50	m.	m.	NOUN
admet-194	337	51	fernandez	fernandez	PROPN
admet-194	337	52	,	,	PUNCT
admet-194	337	53	s.	s.	PROPN
admet-194	337	54	sivilia	sivilia	PROPN
admet-194	337	55	,	,	PUNCT
admet-194	337	56	l.	l.	PROPN
admet-194	337	57	giardino	giardino	PROPN
admet-194	337	58	,	,	PUNCT
admet-194	337	59	l.	l.	PROPN
admet-194	337	60	calza	calza	PROPN
admet-194	337	61	,	,	PUNCT
admet-194	337	62	d.	d.	PROPN
admet-194	337	63	norris	norris	PROPN
admet-194	337	64	,	,	PUNCT
admet-194	337	65	h.	h.	PROPN
admet-194	337	66	cicirello	cicirello	PROPN
admet-194	337	67	,	,	PUNCT
admet-194	337	68	d.	d.	PROPN
admet-194	337	69	casula	casula	PROPN
admet-194	337	70	,	,	PUNCT
admet-194	337	71	b.p	b.p	PROPN
admet-194	337	72	.	.	PROPN
admet-194	337	73	imbimbo	imbimbo	PROPN
admet-194	337	74	,	,	PUNCT
admet-194	337	75	current	current	ADJ
admet-194	337	76	alzheimer	alzheimer	PROPN
admet-194	337	77	research	research	PROPN
admet-194	337	78	10	10	NUM
admet-194	337	79	(	(	PUNCT
admet-194	337	80	2013	2013	NUM
admet-194	337	81	)	)	PUNCT
admet-194	337	82	742	742	NUM
admet-194	337	83	-	-	SYM
admet-194	337	84	753	753	NUM
admet-194	337	85	.	.	PUNCT
admet-194	338	1	[	[	X
admet-194	338	2	40	40	NUM
admet-194	338	3	]	]	PUNCT
admet-194	338	4	evaluation	evaluation	NOUN
admet-194	338	5	of	of	ADP
admet-194	338	6	effects	effect	NOUN
admet-194	338	7	of	of	ADP
admet-194	338	8	multiple	multiple	ADJ
admet-194	338	9	dose	dose	NOUN
admet-194	338	10	regimens	regimen	NOUN
admet-194	338	11	of	of	ADP
admet-194	338	12	chf	chf	NOUN
admet-194	338	13	5074	5074	NUM
admet-194	338	14	on	on	ADP
admet-194	338	15	potential	potential	ADJ
admet-194	338	16	biomarkers	biomarker	NOUN
admet-194	338	17	of	of	ADP
admet-194	338	18	neurodegeneration	neurodegeneration	NOUN
admet-194	338	19	in	in	ADP
admet-194	338	20	subjects	subject	NOUN
admet-194	338	21	with	with	ADP
admet-194	338	22	mild	mild	ADJ
admet-194	338	23	cognitive	cognitive	ADJ
admet-194	338	24	impairment	impairment	NOUN
admet-194	338	25	(	(	PUNCT
admet-194	338	26	ct05	ct05	PROPN
admet-194	338	27	)	)	PUNCT
admet-194	338	28	,	,	PUNCT
admet-194	338	29	https://clinicaltrials.gov/ct2/show/nct01723670?term=chf-5074&rank=7	https://clinicaltrials.gov/ct2/show/nct01723670?term=chf-5074&rank=7	X
admet-194	338	30	(	(	PUNCT
admet-194	338	31	february	february	PROPN
admet-194	338	32	2015	2015	NUM
admet-194	338	33	)	)	PUNCT
admet-194	338	34	.	.	PUNCT
admet-194	339	1	[	[	X
admet-194	339	2	41	41	NUM
admet-194	339	3	]	]	X
admet-194	339	4	b.	b.	PROPN
admet-194	339	5	vellas	vellas	PROPN
admet-194	339	6	,	,	PUNCT
admet-194	339	7	o.	o.	PROPN
admet-194	339	8	sol	sol	PROPN
admet-194	339	9	,	,	PUNCT
admet-194	339	10	p.j	p.j	PROPN
admet-194	339	11	.	.	PROPN
admet-194	339	12	snyder	snyder	PROPN
admet-194	339	13	,	,	PUNCT
admet-194	339	14	p.j	p.j	PROPN
admet-194	339	15	.	.	PROPN
admet-194	339	16	ousset	ousset	PROPN
admet-194	339	17	,	,	PUNCT
admet-194	339	18	r.	r.	PROPN
admet-194	339	19	haddad	haddad	PROPN
admet-194	339	20	,	,	PUNCT
admet-194	339	21	m.	m.	NOUN
admet-194	339	22	maurin	maurin	NOUN
admet-194	339	23	,	,	PUNCT
admet-194	339	24	j.c	j.c	PROPN
admet-194	339	25	.	.	PROPN
admet-194	339	26	lemarié	lemarié	PROPN
admet-194	339	27	,	,	PUNCT
admet-194	339	28	l.	l.	PROPN
admet-194	339	29	désiré	désiré	PROPN
admet-194	339	30	,	,	PUNCT
admet-194	339	31	m.p	m.p	PROPN
admet-194	339	32	.	.	PROPN
admet-194	339	33	pando	pando	PROPN
admet-194	339	34	,	,	PUNCT
admet-194	339	35	current	current	ADJ
admet-194	339	36	alzheimer	alzheimer	PROPN
admet-194	339	37	research	research	NOUN
admet-194	339	38	8	8	NUM
admet-194	339	39	(	(	PUNCT
admet-194	339	40	2011	2011	NUM
admet-194	339	41	)	)	PUNCT
admet-194	339	42	203	203	NUM
admet-194	339	43	-	-	SYM
admet-194	339	44	212	212	NUM
admet-194	339	45	.	.	PUNCT
admet-194	340	1	[	[	X
admet-194	340	2	42	42	NUM
admet-194	340	3	]	]	PUNCT
admet-194	340	4	r.	r.	PROPN
admet-194	340	5	etcheberrigaray	etcheberrigaray	PROPN
admet-194	340	6	,	,	PUNCT
admet-194	340	7	m.	m.	PROPN
admet-194	340	8	tan	tan	PROPN
admet-194	340	9	,	,	PUNCT
admet-194	340	10	i.	i.	PROPN
admet-194	340	11	dewachter	dewachter	PROPN
admet-194	340	12	,	,	PUNCT
admet-194	340	13	c.	c.	PROPN
admet-194	340	14	kuipéri	kuipéri	PROPN
admet-194	340	15	,	,	PUNCT
admet-194	340	16	i.	i.	PROPN
admet-194	340	17	van	van	PROPN
admet-194	340	18	der	der	PROPN
admet-194	340	19	auwera	auwera	PROPN
admet-194	340	20	,	,	PUNCT
admet-194	340	21	s.	s.	PROPN
admet-194	340	22	wera	wera	PROPN
admet-194	340	23	,	,	PUNCT
admet-194	340	24	l.	l.	PROPN
admet-194	340	25	qiao	qiao	PROPN
admet-194	340	26	,	,	PUNCT
admet-194	340	27	b.	b.	PROPN
admet-194	340	28	bank	bank	PROPN
admet-194	340	29	,	,	PUNCT
admet-194	340	30	t.j	t.j	PROPN
admet-194	340	31	.	.	PROPN
admet-194	340	32	nelson	nelson	PROPN
admet-194	340	33	,	,	PUNCT
admet-194	340	34	a.p	a.p	PROPN
admet-194	340	35	.	.	PROPN
admet-194	340	36	kozikowski	kozikowski	PROPN
admet-194	340	37	,	,	PUNCT
admet-194	340	38	f.	f.	PROPN
admet-194	340	39	van	van	PROPN
admet-194	340	40	leuven	leuven	PROPN
admet-194	340	41	,	,	PUNCT
admet-194	340	42	d.l	d.l	PROPN
admet-194	340	43	.	.	PROPN
admet-194	340	44	alkon	alkon	PROPN
admet-194	340	45	,	,	PUNCT
admet-194	340	46	proceedings	proceeding	NOUN
admet-194	340	47	of	of	ADP
admet-194	340	48	the	the	DET
admet-194	340	49	national	national	PROPN
admet-194	340	50	academy	academy	PROPN
admet-194	340	51	of	of	ADP
admet-194	340	52	sciences	sciences	PROPN
admet-194	340	53	of	of	ADP
admet-194	340	54	the	the	DET
admet-194	340	55	united	united	PROPN
admet-194	340	56	states	states	PROPN
admet-194	340	57	of	of	ADP
admet-194	340	58	america	america	PROPN
admet-194	340	59	101	101	NUM
admet-194	340	60	(	(	PUNCT
admet-194	340	61	2004	2004	NUM
admet-194	340	62	)	)	PUNCT
admet-194	340	63	11141	11141	NUM
admet-194	340	64	-	-	SYM
admet-194	340	65	11146	11146	NUM
admet-194	340	66	.	.	PUNCT
admet-194	341	1	[	[	X
admet-194	341	2	43	43	NUM
admet-194	341	3	]	]	X
admet-194	341	4	safety	safety	NOUN
admet-194	341	5	,	,	PUNCT
admet-194	341	6	efficacy	efficacy	NOUN
admet-194	341	7	,	,	PUNCT
admet-194	341	8	pharmacokinetics	pharmacokinetic	NOUN
admet-194	341	9	,	,	PUNCT
admet-194	341	10	and	and	CCONJ
admet-194	341	11	pharmacodynamics	pharmacodynamic	NOUN
admet-194	341	12	study	study	NOUN
admet-194	341	13	of	of	ADP
admet-194	341	14	bryostatin	bryostatin	PROPN
admet-194	341	15	1	1	NUM
admet-194	341	16	in	in	ADP
admet-194	341	17	patients	patient	NOUN
admet-194	341	18	with	with	ADP
admet-194	341	19	alzheimer	alzheimer	PROPN
admet-194	341	20	's	's	PART
admet-194	341	21	disease	disease	NOUN
admet-194	341	22	,	,	PUNCT
admet-194	341	23	https://clinicaltrials.gov/ct2/show/nct00606164?term=bryostatin1+alzheimer&rank=1	https://clinicaltrials.gov/ct2/show/nct00606164?term=bryostatin1+alzheimer&rank=1	PROPN
admet-194	341	24	(	(	PUNCT
admet-194	341	25	january	january	PROPN
admet-194	341	26	2008	2008	NUM
admet-194	341	27	)	)	PUNCT
admet-194	341	28	.	.	PUNCT
admet-194	342	1	[	[	X
admet-194	342	2	44	44	NUM
admet-194	342	3	]	]	PUNCT
admet-194	342	4	study	study	NOUN
admet-194	342	5	to	to	PART
admet-194	342	6	evaluate	evaluate	VERB
admet-194	342	7	the	the	DET
admet-194	342	8	preliminary	preliminary	ADJ
admet-194	342	9	safety	safety	NOUN
admet-194	342	10	,	,	PUNCT
admet-194	342	11	efficacy	efficacy	NOUN
admet-194	342	12	,	,	PUNCT
admet-194	342	13	pk	pk	NOUN
admet-194	342	14	and	and	CCONJ
admet-194	342	15	pd	pd	PROPN
admet-194	342	16	of	of	ADP
admet-194	342	17	bryostatin	bryostatin	PROPN
admet-194	342	18	1	1	NUM
admet-194	342	19	in	in	ADP
admet-194	342	20	patients	patient	NOUN
admet-194	342	21	with	with	ADP
admet-194	342	22	alzheimer	alzheimer	PROPN
admet-194	342	23	's	's	PART
admet-194	342	24	disease	disease	NOUN
admet-194	342	25	,	,	PUNCT
admet-194	342	26	https://clinicaltrials.gov/ct2/show/nct02221947?term=bryostatin1+alzheimer&rank=2	https://clinicaltrials.gov/ct2/show/nct02221947?term=bryostatin1+alzheimer&rank=2	PROPN
admet-194	342	27	(	(	PUNCT
admet-194	342	28	april	april	PROPN
admet-194	342	29	2015	2015	NUM
admet-194	342	30	)	)	PUNCT
admet-194	342	31	.	.	PUNCT
admet-194	343	1	[	[	X
admet-194	343	2	45	45	NUM
admet-194	343	3	]	]	PUNCT
admet-194	343	4	a	a	DET
admet-194	343	5	study	study	NOUN
admet-194	343	6	assessing	assess	VERB
admet-194	343	7	bryostatin	bryostatin	NOUN
admet-194	343	8	in	in	ADP
admet-194	343	9	the	the	DET
admet-194	343	10	treatment	treatment	NOUN
admet-194	343	11	of	of	ADP
admet-194	343	12	moderately	moderately	ADV
admet-194	343	13	severe	severe	ADJ
admet-194	343	14	to	to	ADP
admet-194	343	15	severe	severe	ADJ
admet-194	343	16	alzheimer	alzheimer	PROPN
admet-194	343	17	's	's	PART
admet-194	343	18	disease	disease	NOUN
admet-194	343	19	,	,	PUNCT
admet-194	343	20	https://clinicaltrials.gov/ct2/show/nct02431468?term=bryostatin-1+alzheimer&rank=3	https://clinicaltrials.gov/ct2/show/nct02431468?term=bryostatin-1+alzheimer&rank=3	NOUN
admet-194	343	21	(	(	PUNCT
admet-194	343	22	april	april	PROPN
admet-194	343	23	2015	2015	NUM
admet-194	343	24	)	)	PUNCT
admet-194	343	25	.	.	PUNCT
admet-194	344	1	[	[	X
admet-194	344	2	46	46	NUM
admet-194	344	3	]	]	X
admet-194	344	4	a.d	a.d	PROPN
admet-194	344	5	.	.	PROPN
admet-194	344	6	snow	snow	PROPN
admet-194	344	7	,	,	PUNCT
admet-194	344	8	j.	j.	PROPN
admet-194	344	9	cummings	cummings	PROPN
admet-194	344	10	,	,	PUNCT
admet-194	344	11	t.	t.	PROPN
admet-194	344	12	lake	lake	PROPN
admet-194	344	13	,	,	PUNCT
admet-194	344	14	q.	q.	PROPN
admet-194	344	15	hu	hu	PROPN
admet-194	344	16	,	,	PUNCT
admet-194	344	17	l.	l.	PROPN
admet-194	344	18	esposito	esposito	PROPN
admet-194	344	19	,	,	PUNCT
admet-194	344	20	j.	j.	PROPN
admet-194	344	21	cam	cam	PROPN
admet-194	344	22	,	,	PUNCT
admet-194	344	23	m.	m.	PROPN
admet-194	344	24	hudson	hudson	PROPN
admet-194	344	25	,	,	PUNCT
admet-194	344	26	e.	e.	PROPN
admet-194	344	27	smith	smith	PROPN
admet-194	344	28	,	,	PUNCT
admet-194	344	29	s.	s.	PROPN
admet-194	344	30	runnels	runnels	PROPN
admet-194	344	31	,	,	PUNCT
admet-194	344	32	alzheimer	alzheimer	PROPN
admet-194	344	33	’s	’s	PART
admet-194	344	34	&	&	CCONJ
admet-194	344	35	dementia	dementia	PROPN
admet-194	344	36	5	5	NUM
admet-194	344	37	(	(	PUNCT
admet-194	344	38	2009	2009	NUM
admet-194	344	39	)	)	PUNCT
admet-194	344	40	418	418	NUM
admet-194	344	41	.	.	PUNCT
admet-194	345	1	[	[	X
admet-194	345	2	47	47	NUM
admet-194	345	3	]	]	PUNCT
admet-194	345	4	s.	s.	PROPN
admet-194	345	5	gilman	gilman	PROPN
admet-194	345	6	,	,	PUNCT
admet-194	345	7	m.	m.	PROPN
admet-194	345	8	koller	koller	PROPN
admet-194	345	9	,	,	PUNCT
admet-194	345	10	r.s	r.s	PROPN
admet-194	345	11	.	.	PROPN
admet-194	345	12	black	black	PROPN
admet-194	345	13	,	,	PUNCT
admet-194	345	14	l.	l.	PROPN
admet-194	345	15	jenkins	jenkins	PROPN
admet-194	345	16	,	,	PUNCT
admet-194	345	17	s.g	s.g	PROPN
admet-194	345	18	.	.	PROPN
admet-194	345	19	griffith	griffith	PROPN
admet-194	345	20	,	,	PUNCT
admet-194	345	21	n.c	n.c	PROPN
admet-194	345	22	.	.	PROPN
admet-194	345	23	fox	fox	PROPN
admet-194	345	24	,	,	PUNCT
admet-194	345	25	l.	l.	PROPN
admet-194	345	26	eisner	eisner	PROPN
admet-194	345	27	,	,	PUNCT
admet-194	345	28	l.	l.	PROPN
admet-194	345	29	kirby	kirby	PROPN
admet-194	345	30	,	,	PUNCT
admet-194	345	31	m.b	m.b	PROPN
admet-194	345	32	.	.	PROPN
admet-194	345	33	rovira	rovira	PROPN
admet-194	345	34	,	,	PUNCT
admet-194	345	35	f.	f.	PROPN
admet-194	345	36	forette	forette	PROPN
admet-194	345	37	,	,	PUNCT
admet-194	345	38	j.m	j.m	PROPN
admet-194	345	39	.	.	PROPN
admet-194	345	40	orgogozo	orgogozo	PROPN
admet-194	345	41	,	,	PUNCT
admet-194	345	42	an1792(qs-21)-201	an1792(qs-21)-201	NOUN
admet-194	345	43	study	study	NOUN
admet-194	345	44	team	team	NOUN
admet-194	345	45	,	,	PUNCT
admet-194	345	46	neurology	neurology	NOUN
admet-194	345	47	64	64	NUM
admet-194	345	48	(	(	PUNCT
admet-194	345	49	2005	2005	NUM
admet-194	345	50	)	)	PUNCT
admet-194	345	51	1553	1553	NUM
admet-194	345	52	-	-	SYM
admet-194	345	53	1562	1562	NUM
admet-194	345	54	.	.	PUNCT
admet-194	346	1	[	[	X
admet-194	346	2	48	48	NUM
admet-194	346	3	]	]	PUNCT
admet-194	346	4	b.	b.	PROPN
admet-194	346	5	winblad	winblad	PROPN
admet-194	346	6	,	,	PUNCT
admet-194	346	7	n.	n.	NOUN
admet-194	346	8	andreasen	andreasen	PROPN
admet-194	346	9	,	,	PUNCT
admet-194	346	10	l.	l.	PROPN
admet-194	346	11	minthon	minthon	PROPN
admet-194	346	12	,	,	PUNCT
admet-194	346	13	a.	a.	NOUN
admet-194	346	14	floesser	floesser	PROPN
admet-194	346	15	,	,	PUNCT
admet-194	346	16	g.	g.	PROPN
admet-194	346	17	imbert	imbert	PROPN
admet-194	346	18	,	,	PUNCT
admet-194	346	19	t.	t.	PROPN
admet-194	346	20	dumortier	dumortier	NOUN
admet-194	346	21	,	,	PUNCT
admet-194	346	22	r.p	r.p	PROPN
admet-194	346	23	.	.	PROPN
admet-194	346	24	maguire	maguire	PROPN
admet-194	346	25	,	,	PUNCT
admet-194	346	26	k.	k.	PROPN
admet-194	346	27	blennow	blennow	PROPN
admet-194	346	28	,	,	PUNCT
admet-194	346	29	j.	j.	PROPN
admet-194	346	30	lundmark	lundmark	PROPN
admet-194	346	31	,	,	PUNCT
admet-194	346	32	m.	m.	PROPN
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admet-194	346	34	,	,	PUNCT
admet-194	346	35	j.m	j.m	PROPN
admet-194	346	36	.	.	PROPN
admet-194	346	37	orgogozo	orgogozo	PROPN
admet-194	346	38	,	,	PUNCT
admet-194	346	39	a.	a.	NOUN
admet-194	346	40	graf	graf	PROPN
admet-194	346	41	,	,	PUNCT
admet-194	346	42	lancet	lancet	NOUN
admet-194	346	43	neurology	neurology	NOUN
admet-194	346	44	11	11	NUM
admet-194	346	45	(	(	PUNCT
admet-194	346	46	2012	2012	NUM
admet-194	346	47	)	)	PUNCT
admet-194	346	48	597	597	NUM
admet-194	346	49	-	-	SYM
admet-194	346	50	604	604	NUM
admet-194	346	51	[	[	X
admet-194	346	52	49	49	NUM
admet-194	346	53	]	]	PUNCT
admet-194	346	54	d.	d.	PROPN
admet-194	346	55	l.	l.	PROPN
admet-194	346	56	brody	brody	PROPN
admet-194	346	57	,	,	PUNCT
admet-194	346	58	d.	d.	PROPN
admet-194	346	59	m.	m.	PROPN
admet-194	346	60	holtzman	holtzman	PROPN
admet-194	346	61	,	,	PUNCT
admet-194	346	62	annual	annual	ADJ
admet-194	346	63	review	review	NOUN
admet-194	346	64	in	in	ADP
admet-194	346	65	neuroscience	neuroscience	NOUN
admet-194	346	66	31	31	NUM
admet-194	346	67	(	(	PUNCT
admet-194	346	68	2008	2008	NUM
admet-194	346	69	)	)	PUNCT
admet-194	346	70	175	175	NUM
admet-194	346	71	-	-	SYM
admet-194	346	72	193	193	NUM
admet-194	346	73	.	.	PUNCT
admet-194	347	1	[	[	X
admet-194	347	2	50	50	NUM
admet-194	347	3	]	]	PUNCT
admet-194	347	4	pfizer	pfizer	NOUN
admet-194	347	5	pipeline	pipeline	NOUN
admet-194	347	6	,	,	PUNCT
admet-194	347	7	http://www.pfizer.com/sites/default/files/product-pipeline/pipeline_080913_0.pdf	http://www.pfizer.com/sites/default/files/product-pipeline/pipeline_080913_0.pdf	PROPN
admet-194	347	8	(	(	PUNCT
admet-194	347	9	august	august	PROPN
admet-194	347	10	9	9	NUM
admet-194	347	11	,	,	PUNCT
admet-194	347	12	2013	2013	NUM
admet-194	347	13	)	)	PUNCT
admet-194	347	14	.	.	PUNCT
admet-194	348	1	[	[	X
admet-194	348	2	51	51	NUM
admet-194	348	3	]	]	PUNCT
admet-194	348	4	a.	a.	NOUN
admet-194	348	5	muhs	muhs	PROPN
admet-194	348	6	,	,	PUNCT
admet-194	348	7	d.t	d.t	PROPN
admet-194	348	8	.	.	PROPN
admet-194	348	9	hickman	hickman	PROPN
admet-194	348	10	,	,	PUNCT
admet-194	348	11	m.	m.	NOUN
admet-194	348	12	pihlgren	pihlgren	PROPN
admet-194	348	13	,	,	PUNCT
admet-194	348	14	n.	n.	NOUN
admet-194	348	15	chuard	chuard	NOUN
admet-194	348	16	,	,	PUNCT
admet-194	348	17	v.	v.	CCONJ
admet-194	348	18	giriens	giriens	PROPN
admet-194	348	19	,	,	PUNCT
admet-194	348	20	c.	c.	PROPN
admet-194	348	21	meerschman	meerschman	NOUN
admet-194	348	22	,	,	PUNCT
admet-194	348	23	i.	i.	PROPN
admet-194	348	24	van	van	PROPN
admet-194	348	25	der	der	PROPN
admet-194	348	26	auwera	auwera	PROPN
admet-194	348	27	,	,	PUNCT
admet-194	348	28	f.	f.	PROPN
admet-194	348	29	van	van	PROPN
admet-194	348	30	leuven	leuven	PROPN
admet-194	348	31	,	,	PUNCT
admet-194	348	32	m.	m.	NOUN
admet-194	348	33	sugawara	sugawara	PROPN
admet-194	348	34	,	,	PUNCT
admet-194	348	35	m.c	m.c	PROPN
admet-194	348	36	.	.	PROPN
admet-194	348	37	weingertner	weingertner	PROPN
admet-194	348	38	,	,	PUNCT
admet-194	348	39	b.	b.	PROPN
admet-194	348	40	bechinger	bechinger	PROPN
admet-194	348	41	,	,	PUNCT
admet-194	348	42	r.	r.	PROPN
admet-194	348	43	greferath	greferath	PROPN
admet-194	348	44	,	,	PUNCT
admet-194	348	45	n.	n.	PROPN
admet-194	348	46	kolonko	kolonko	PROPN
admet-194	348	47	,	,	PUNCT
admet-194	348	48	l.	l.	PROPN
admet-194	348	49	nagel	nagel	PROPN
admet-194	348	50	-	-	PUNCT
admet-194	348	51	steger	steger	PROPN
admet-194	348	52	,	,	PUNCT
admet-194	348	53	d.	d.	PROPN
admet-194	348	54	riesner	riesner	PROPN
admet-194	348	55	,	,	PUNCT
admet-194	348	56	r.o	r.o	PROPN
admet-194	348	57	.	.	PROPN
admet-194	348	58	brady	brady	PROPN
admet-194	348	59	,	,	PUNCT
admet-194	348	60	a.	a.	NOUN
admet-194	348	61	pfeifer	pfeifer	PROPN
admet-194	348	62	,	,	PUNCT
admet-194	348	63	c.	c.	PROPN
admet-194	348	64	nicolau	nicolau	PROPN
admet-194	348	65	,	,	PUNCT
admet-194	348	66	proceedings	proceeding	NOUN
admet-194	348	67	of	of	ADP
admet-194	348	68	the	the	DET
admet-194	348	69	national	national	PROPN
admet-194	348	70	academy	academy	PROPN
admet-194	348	71	of	of	ADP
admet-194	348	72	sciences	sciences	PROPN
admet-194	348	73	of	of	ADP
admet-194	348	74	the	the	DET
admet-194	348	75	united	united	PROPN
admet-194	348	76	states	states	PROPN
admet-194	348	77	of	of	ADP
admet-194	348	78	america	america	PROPN
admet-194	348	79	104	104	NUM
admet-194	348	80	(	(	PUNCT
admet-194	348	81	2007	2007	NUM
admet-194	348	82	)	)	PUNCT
admet-194	348	83	9810	9810	NUM
admet-194	348	84	-	-	SYM
admet-194	348	85	9815	9815	NUM
admet-194	348	86	.	.	PUNCT
admet-194	349	1	[	[	X
admet-194	349	2	52	52	NUM
admet-194	349	3	]	]	PUNCT
admet-194	349	4	c.	c.	PROPN
admet-194	349	5	y.	y.	PROPN
admet-194	349	6	w.	w.	PROPN
admet-194	349	7	s.	s.	PROPN
admet-194	349	8	lynn	lynn	PROPN
admet-194	349	9	*	*	PROPN
admet-194	349	10	,	,	PUNCT
admet-194	349	11	c.	c.	PROPN
admet-194	349	12	l.	l.	PROPN
admet-194	349	13	finstad	finstad	PROPN
admet-194	349	14	,	,	PUNCT
admet-194	349	15	s.-n	s.-n	PROPN
admet-194	349	16	.	.	PUNCT
admet-194	350	1	hsu	hsu	PROPN
admet-194	350	2	,	,	PUNCT
admet-194	350	3	y.	y.	PROPN
admet-194	350	4	kao	kao	PROPN
admet-194	350	5	,	,	PUNCT
admet-194	350	6	c.-f	c.-f	NOUN
admet-194	350	7	.	.	PUNCT
admet-194	351	1	wu	wu	PROPN
admet-194	351	2	,	,	PUNCT
admet-194	351	3	p.-n	p.-n	PROPN
admet-194	351	4	.	.	PUNCT
admet-194	352	1	wang	wang	PROPN
admet-194	352	2	,	,	PUNCT
admet-194	352	3	m.-j	m.-j	PROPN
admet-194	352	4	.	.	PUNCT
admet-194	353	1	chiu	chiu	PROPN
admet-194	353	2	,	,	PUNCT
admet-194	353	3	28th	28th	ADJ
admet-194	353	4	international	international	ADJ
admet-194	353	5	conference	conference	NOUN
admet-194	353	6	of	of	ADP
admet-194	353	7	alzheimer	alzheimer	PROPN
admet-194	353	8	's	's	PART
admet-194	353	9	disease	disease	NOUN
admet-194	353	10	international	international	ADJ
admet-194	353	11	(	(	PUNCT
admet-194	353	12	2013	2013	NUM
admet-194	353	13	)	)	PUNCT
admet-194	353	14	40	40	NUM
admet-194	353	15	.	.	PUNCT
admet-194	354	1	[	[	X
admet-194	354	2	53	53	NUM
admet-194	354	3	]	]	PUNCT
admet-194	354	4	study	study	NOUN
admet-194	354	5	to	to	PART
admet-194	354	6	evaluate	evaluate	VERB
admet-194	354	7	safety	safety	NOUN
admet-194	354	8	,	,	PUNCT
admet-194	354	9	tolerability	tolerability	NOUN
admet-194	354	10	and	and	CCONJ
admet-194	354	11	immunogenicity	immunogenicity	NOUN
admet-194	354	12	of	of	ADP
admet-194	354	13	vaccine	vaccine	NOUN
admet-194	354	14	(	(	PUNCT
admet-194	354	15	ub	ub	PROPN
admet-194	354	16	311	311	NUM
admet-194	354	17	)	)	PUNCT
admet-194	354	18	in	in	ADP
admet-194	354	19	subjects	subject	NOUN
admet-194	354	20	with	with	ADP
admet-194	354	21	alzheimer	alzheimer	PROPN
admet-194	354	22	's	's	PART
admet-194	354	23	disease	disease	NOUN
admet-194	354	24	,	,	PUNCT
admet-194	354	25	https://clinicaltrials.gov/ct2/show/nct00965588?term=ub311&rank=1	https://clinicaltrials.gov/ct2/show/nct00965588?term=ub311&rank=1	PROPN
admet-194	354	26	(	(	PUNCT
admet-194	354	27	august	august	PROPN
admet-194	354	28	2011	2011	NUM
admet-194	354	29	)	)	PUNCT
admet-194	354	30	.	.	PUNCT
admet-194	355	1	[	[	X
admet-194	355	2	54	54	NUM
admet-194	355	3	]	]	PUNCT
admet-194	355	4	b.	b.	PROPN
admet-194	355	5	winblad	winblad	PROPN
admet-194	355	6	,	,	PUNCT
admet-194	355	7	a.	a.	NOUN
admet-194	355	8	graf	graf	PROPN
admet-194	355	9	,	,	PUNCT
admet-194	355	10	m.	m.	PROPN
admet-194	355	11	e.	e.	PROPN
admet-194	355	12	riviere	riviere	PROPN
admet-194	355	13	,	,	PUNCT
admet-194	355	14	n.	n.	PROPN
admet-194	355	15	andreasen	andreasen	PROPN
admet-194	355	16	,	,	PUNCT
admet-194	355	17	j.	j.	PROPN
admet-194	355	18	m.	m.	PROPN
admet-194	355	19	ryan	ryan	PROPN
admet-194	355	20	,	,	PUNCT
admet-194	355	21	alzheimer	alzheimer	PROPN
admet-194	355	22	's	's	PART
admet-194	355	23	research	research	NOUN
admet-194	355	24	&	&	CCONJ
admet-194	355	25	therapy	therapy	NOUN
admet-194	355	26	6	6	NUM
admet-194	355	27	(	(	PUNCT
admet-194	355	28	2014	2014	NUM
admet-194	355	29	)	)	PUNCT
admet-194	355	30	7	7	NUM
admet-194	355	31	.	.	PUNCT
admet-194	356	1	[	[	X
admet-194	356	2	55	55	NUM
admet-194	356	3	]	]	X
admet-194	356	4	d.	d.	PROPN
admet-194	356	5	m.	m.	PROPN
admet-194	356	6	wilcock	wilcock	PROPN
admet-194	356	7	,	,	PUNCT
admet-194	356	8	p.	p.	NOUN
admet-194	356	9	t.	t.	PROPN
admet-194	356	10	jantzen	jantzen	PROPN
admet-194	356	11	,	,	PUNCT
admet-194	356	12	q.	q.	PROPN
admet-194	356	13	li	li	PROPN
admet-194	356	14	,	,	PUNCT
admet-194	356	15	d.	d.	PROPN
admet-194	356	16	morgan	morgan	PROPN
admet-194	356	17	,	,	PUNCT
admet-194	356	18	m.	m.	PROPN
admet-194	356	19	n.	n.	PROPN
admet-194	356	20	gordon	gordon	PROPN
admet-194	356	21	,	,	PUNCT
admet-194	356	22	neuroscience	neuroscience	NOUN
admet-194	356	23	144	144	NUM
admet-194	356	24	(	(	PUNCT
admet-194	356	25	2007	2007	NUM
admet-194	356	26	)	)	PUNCT
admet-194	356	27	950	950	NUM
admet-194	356	28	-	-	SYM
admet-194	356	29	960	960	NUM
admet-194	356	30	.	.	PUNCT
admet-194	357	1	[	[	X
admet-194	357	2	56	56	NUM
admet-194	357	3	]	]	X
admet-194	357	4	s.	s.	PROPN
admet-194	357	5	salloway	salloway	PROPN
admet-194	357	6	,	,	PUNCT
admet-194	357	7	r.	r.	PROPN
admet-194	357	8	sperling	sperling	PROPN
admet-194	357	9	,	,	PUNCT
admet-194	357	10	s.	s.	PROPN
admet-194	357	11	gilman	gilman	PROPN
admet-194	357	12	,	,	PUNCT
admet-194	357	13	n.c	n.c	PROPN
admet-194	357	14	.	.	PROPN
admet-194	357	15	fox	fox	PROPN
admet-194	357	16	,	,	PUNCT
admet-194	357	17	k.	k.	PROPN
admet-194	357	18	blennow	blennow	PROPN
admet-194	357	19	,	,	PUNCT
admet-194	357	20	m.	m.	NOUN
admet-194	357	21	raskind	raskind	NOUN
admet-194	357	22	,	,	PUNCT
admet-194	357	23	m.	m.	NOUN
admet-194	357	24	sabbagh	sabbagh	PROPN
admet-194	357	25	,	,	PUNCT
admet-194	357	26	l.s	l.s	PROPN
admet-194	357	27	.	.	PROPN
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admet-194	357	29	,	,	PUNCT
admet-194	357	30	r.	r.	PROPN
admet-194	357	31	doody	doody	PROPN
admet-194	357	32	,	,	PUNCT
admet-194	357	33	c.h	c.h	PROPN
admet-194	357	34	.	.	PROPN
admet-194	358	1	van	van	PROPN
admet-194	358	2	dyck	dyck	PROPN
admet-194	358	3	,	,	PUNCT
admet-194	358	4	r.	r.	PROPN
admet-194	358	5	mulnard	mulnard	PROPN
admet-194	358	6	,	,	PUNCT
admet-194	358	7	j.	j.	PROPN
admet-194	358	8	barakos	barakos	PROPN
admet-194	358	9	,	,	PUNCT
admet-194	358	10	k.m	k.m	PROPN
admet-194	358	11	.	.	PROPN
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admet-194	358	13	,	,	PUNCT
admet-194	358	14	e.	e.	PROPN
admet-194	358	15	liu	liu	PROPN
admet-194	358	16	,	,	PUNCT
admet-194	358	17	i.	i.	PROPN
admet-194	358	18	lieberburg	lieberburg	PROPN
admet-194	358	19	,	,	PUNCT
admet-194	358	20	d.	d.	PROPN
admet-194	358	21	schenk	schenk	PROPN
admet-194	358	22	,	,	PUNCT
admet-194	358	23	r.	r.	PROPN
admet-194	358	24	black	black	PROPN
admet-194	358	25	,	,	PUNCT
admet-194	358	26	m.	m.	NOUN
admet-194	358	27	grundman	grundman	NOUN
admet-194	358	28	;	;	PUNCT
admet-194	358	29	bapineuzumab	bapineuzumab	VERB
admet-194	358	30	201	201	NUM
admet-194	358	31	clinical	clinical	ADJ
admet-194	358	32	trial	trial	NOUN
admet-194	358	33	investigators	investigator	NOUN
admet-194	358	34	,	,	PUNCT
admet-194	358	35	neurology	neurology	NOUN
admet-194	358	36	73	73	NUM
admet-194	358	37	(	(	PUNCT
admet-194	358	38	2009	2009	NUM
admet-194	358	39	)	)	PUNCT
admet-194	358	40	2061	2061	NUM
admet-194	358	41	-	-	SYM
admet-194	358	42	2070	2070	NUM
admet-194	358	43	.	.	PUNCT
admet-194	359	1	[	[	X
admet-194	359	2	57	57	NUM
admet-194	359	3	]	]	PUNCT
admet-194	359	4	s.	s.	PROPN
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admet-194	359	6	,	,	PUNCT
admet-194	359	7	r.	r.	PROPN
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admet-194	359	9	,	,	PUNCT
admet-194	359	10	n.c	n.c	PROPN
admet-194	359	11	.	.	PROPN
admet-194	359	12	fox	fox	PROPN
admet-194	359	13	,	,	PUNCT
admet-194	359	14	k.	k.	PROPN
admet-194	359	15	blennow	blennow	PROPN
admet-194	359	16	,	,	PUNCT
admet-194	359	17	w.	w.	PROPN
admet-194	359	18	klunk	klunk	PROPN
admet-194	359	19	,	,	PUNCT
admet-194	359	20	m.	m.	NOUN
admet-194	359	21	raskind	raskind	NOUN
admet-194	359	22	,	,	PUNCT
admet-194	359	23	m.	m.	NOUN
admet-194	359	24	sabbagh	sabbagh	PROPN
admet-194	359	25	,	,	PUNCT
admet-194	359	26	l.s	l.s	PROPN
admet-194	359	27	.	.	PROPN
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admet-194	359	29	,	,	PUNCT
admet-194	359	30	a.p	a.p	PROPN
admet-194	359	31	.	.	PROPN
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admet-194	359	33	,	,	PUNCT
admet-194	359	34	s.	s.	PROPN
admet-194	359	35	ferris	ferris	PROPN
admet-194	359	36	,	,	PUNCT
admet-194	359	37	m.	m.	PROPN
admet-194	359	38	reichert	reichert	PROPN
admet-194	359	39	,	,	PUNCT
admet-194	359	40	n.	n.	PROPN
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admet-194	359	42	,	,	PUNCT
admet-194	359	43	b.	b.	PROPN
admet-194	359	44	nejadnik	nejadnik	PROPN
admet-194	359	45	,	,	PUNCT
admet-194	359	46	v.	v.	ADP
admet-194	359	47	guenzler	guenzler	NOUN
admet-194	359	48	,	,	PUNCT
admet-194	359	49	m.	m.	NOUN
admet-194	359	50	miloslavsky	miloslavsky	NOUN
admet-194	359	51	,	,	PUNCT
admet-194	359	52	d.	d.	PROPN
admet-194	359	53	wang	wang	PROPN
admet-194	359	54	,	,	PUNCT
admet-194	359	55	y.	y.	PROPN
admet-194	359	56	lu	lu	PROPN
admet-194	359	57	,	,	PUNCT
admet-194	359	58	j.	j.	PROPN
admet-194	359	59	lull	lull	PROPN
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admet-194	359	61	i.c	i.c	PROPN
admet-194	359	62	.	.	PROPN
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admet-194	359	64	,	,	PUNCT
admet-194	359	65	e.	e.	PROPN
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admet-194	359	67	,	,	PUNCT
admet-194	359	68	m.	m.	NOUN
admet-194	359	69	grundman	grundman	PROPN
admet-194	359	70	,	,	PUNCT
admet-194	359	71	e.	e.	PROPN
admet-194	359	72	yuen	yuen	PROPN
admet-194	359	73	,	,	PUNCT
admet-194	359	74	r.	r.	PROPN
admet-194	359	75	black	black	PROPN
admet-194	359	76	,	,	PUNCT
admet-194	359	77	h.r	h.r	PROPN
admet-194	359	78	.	.	PROPN
admet-194	359	79	brashear	brashear	PROPN
admet-194	359	80	;	;	PUNCT
admet-194	359	81	bapineuzumab	bapineuzumab	NOUN
admet-194	359	82	301	301	NUM
admet-194	359	83	and	and	CCONJ
admet-194	359	84	302	302	NUM
admet-194	359	85	clinical	clinical	ADJ
admet-194	359	86	trial	trial	NOUN
admet-194	359	87	investigators	investigator	NOUN
admet-194	359	88	,	,	PUNCT
admet-194	359	89	new	new	PROPN
admet-194	359	90	england	england	PROPN
admet-194	359	91	journal	journal	PROPN
admet-194	359	92	of	of	ADP
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admet-194	359	94	370	370	NUM
admet-194	359	95	(	(	PUNCT
admet-194	359	96	2014	2014	NUM
admet-194	359	97	)	)	PUNCT
admet-194	359	98	322	322	NUM
admet-194	359	99	-	-	SYM
admet-194	359	100	333	333	NUM
admet-194	359	101	.	.	PUNCT
admet-194	360	1	[	[	X
admet-194	360	2	58	58	NUM
admet-194	360	3	]	]	X
admet-194	360	4	e.r	e.r	PROPN
admet-194	360	5	.	.	PROPN
admet-194	360	6	siemers	siemer	NOUN
admet-194	360	7	,	,	PUNCT
admet-194	360	8	s.	s.	PROPN
admet-194	360	9	friedrich	friedrich	PROPN
admet-194	360	10	,	,	PUNCT
admet-194	360	11	r.a	r.a	PROPN
admet-194	360	12	.	.	PROPN
admet-194	360	13	dean	dean	PROPN
admet-194	360	14	,	,	PUNCT
admet-194	360	15	c.r	c.r	PROPN
admet-194	360	16	.	.	PROPN
admet-194	360	17	gonzales	gonzales	PROPN
admet-194	360	18	,	,	PUNCT
admet-194	360	19	m.r	m.r	PROPN
admet-194	360	20	.	.	PROPN
admet-194	360	21	farlow	farlow	PROPN
admet-194	360	22	,	,	PUNCT
admet-194	360	23	s.m	s.m	PROPN
admet-194	360	24	.	.	PROPN
admet-194	360	25	paul	paul	PROPN
admet-194	360	26	,	,	PUNCT
admet-194	360	27	r.b	r.b	PROPN
admet-194	360	28	.	.	PROPN
admet-194	360	29	demattos	demattos	PROPN
admet-194	360	30	,	,	PUNCT
admet-194	360	31	clinical	clinical	ADJ
admet-194	360	32	neuropharmacology	neuropharmacology	NOUN
admet-194	360	33	33	33	NUM
admet-194	360	34	(	(	PUNCT
admet-194	360	35	2010	2010	NUM
admet-194	360	36	)	)	PUNCT
admet-194	360	37	67	67	NUM
admet-194	360	38	-	-	SYM
admet-194	360	39	73	73	NUM
admet-194	360	40	.	.	PUNCT
admet-194	361	1	https://clinicaltrials.gov/ct2/show/nct01723670?term=chf-5074&rank=7	https://clinicaltrials.gov/ct2/show/nct01723670?term=chf-5074&rank=7	NOUN
admet-194	361	2	https://clinicaltrials.gov/ct2/show/nct00606164?term=bryostatin-1+alzheimer&rank=1	https://clinicaltrials.gov/ct2/show/nct00606164?term=bryostatin-1+alzheimer&rank=1	PROPN
admet-194	361	3	https://clinicaltrials.gov/ct2/show/nct00606164?term=bryostatin-1+alzheimer&rank=1	https://clinicaltrials.gov/ct2/show/nct00606164?term=bryostatin-1+alzheimer&rank=1	PROPN
admet-194	361	4	https://clinicaltrials.gov/ct2/show/nct02221947?term=bryostatin-1+alzheimer&rank=2	https://clinicaltrials.gov/ct2/show/nct02221947?term=bryostatin-1+alzheimer&rank=2	PROPN
admet-194	361	5	https://clinicaltrials.gov/ct2/show/nct02221947?term=bryostatin-1+alzheimer&rank=2	https://clinicaltrials.gov/ct2/show/nct02221947?term=bryostatin-1+alzheimer&rank=2	NOUN
admet-194	361	6	https://clinicaltrials.gov/ct2/show/nct02431468?term=bryostatin-1+alzheimer&rank=3	https://clinicaltrials.gov/ct2/show/nct02431468?term=bryostatin-1+alzheimer&rank=3	VERB
admet-194	361	7	http://www.pfizer.com/sites/default/files/product-pipeline/pipeline_080913_0.pdf	http://www.pfizer.com/sites/default/files/product-pipeline/pipeline_080913_0.pdf	ADJ
admet-194	361	8	https://clinicaltrials.gov/ct2/show/nct00965588?term=ub311&rank=1	https://clinicaltrials.gov/ct2/show/nct00965588?term=ub311&rank=1	PROPN
admet-194	361	9	admet	admet	PROPN
admet-194	361	10	&	&	CCONJ
admet-194	361	11	dmpk	dmpk	PROPN
admet-194	361	12	3(3	3(3	NUM
admet-194	361	13	)	)	PUNCT
admet-194	361	14	(	(	PUNCT
admet-194	361	15	2015	2015	NUM
admet-194	361	16	)	)	PUNCT
admet-194	361	17	216	216	NUM
admet-194	361	18	-	-	SYM
admet-194	361	19	234	234	NUM
admet-194	361	20	chemical	chemical	NOUN
admet-194	361	21	and	and	CCONJ
admet-194	361	22	physical	physical	ADJ
admet-194	361	23	approaches	approach	NOUN
admet-194	361	24	for	for	ADP
admet-194	361	25	the	the	DET
admet-194	361	26	treatment	treatment	NOUN
admet-194	361	27	of	of	ADP
admet-194	361	28	ad	ad	NOUN
admet-194	361	29	doi	doi	NOUN
admet-194	361	30	:	:	PUNCT
admet-194	361	31	10.5599	10.5599	NUM
admet-194	361	32	/	/	SYM
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admet-194	361	35	[	[	SYM
admet-194	361	36	59	59	NUM
admet-194	361	37	]	]	PUNCT
admet-194	361	38	m.	m.	NOUN
admet-194	361	39	farlow	farlow	NOUN
admet-194	361	40	,	,	PUNCT
admet-194	361	41	s.e	s.e	PROPN
admet-194	361	42	.	.	PROPN
admet-194	361	43	arnold	arnold	PROPN
admet-194	361	44	,	,	PUNCT
admet-194	361	45	c.h	c.h	PROPN
admet-194	361	46	.	.	PROPN
admet-194	361	47	van	van	PROPN
admet-194	361	48	dyck	dyck	PROPN
admet-194	361	49	,	,	PUNCT
admet-194	361	50	p.s	p.s	PROPN
admet-194	361	51	.	.	PROPN
admet-194	361	52	aisen	aisen	PROPN
admet-194	361	53	,	,	PUNCT
admet-194	361	54	b.j	b.j	PROPN
admet-194	361	55	.	.	PROPN
admet-194	361	56	snider	snider	PROPN
admet-194	361	57	,	,	PUNCT
admet-194	361	58	a.p	a.p	PROPN
admet-194	361	59	.	.	PROPN
admet-194	361	60	porsteinsson	porsteinsson	PROPN
admet-194	361	61	,	,	PUNCT
admet-194	361	62	s.	s.	PROPN
admet-194	361	63	friedrich	friedrich	PROPN
admet-194	361	64	,	,	PUNCT
admet-194	361	65	r.a	r.a	PROPN
admet-194	361	66	.	.	PROPN
admet-194	361	67	dean	dean	PROPN
admet-194	361	68	,	,	PUNCT
admet-194	361	69	c.	c.	PROPN
admet-194	361	70	gonzales	gonzales	PROPN
admet-194	361	71	,	,	PUNCT
admet-194	361	72	g.	g.	PROPN
admet-194	361	73	sethuraman	sethuraman	PROPN
admet-194	361	74	,	,	PUNCT
admet-194	361	75	r.b	r.b	PROPN
admet-194	361	76	.	.	PROPN
admet-194	361	77	demattos	demattos	PROPN
admet-194	361	78	,	,	PUNCT
admet-194	361	79	r.	r.	PROPN
admet-194	361	80	mohs	mohs	PROPN
admet-194	361	81	,	,	PUNCT
admet-194	361	82	s.m	s.m	PROPN
admet-194	361	83	.	.	PROPN
admet-194	361	84	paul	paul	PROPN
admet-194	361	85	,	,	PUNCT
admet-194	361	86	e.r	e.r	PROPN
admet-194	361	87	.	.	PROPN
admet-194	361	88	siemers	siemer	NOUN
admet-194	361	89	,	,	PUNCT
admet-194	361	90	alzheimer	alzheimer	PROPN
admet-194	361	91	’s	’s	PART
admet-194	361	92	&	&	CCONJ
admet-194	361	93	dementia	dementia	PROPN
admet-194	361	94	8	8	NUM
admet-194	361	95	(	(	PUNCT
admet-194	361	96	2012	2012	NUM
admet-194	361	97	)	)	PUNCT
admet-194	361	98	261	261	NUM
admet-194	361	99	-	-	SYM
admet-194	361	100	271	271	NUM
admet-194	361	101	.	.	PUNCT
admet-194	362	1	[	[	X
admet-194	362	2	60	60	NUM
admet-194	362	3	]	]	X
admet-194	362	4	r.s	r.s	PROPN
admet-194	362	5	.	.	PROPN
admet-194	362	6	doody	doody	PROPN
admet-194	362	7	,	,	PUNCT
admet-194	362	8	r.g	r.g	PROPN
admet-194	362	9	.	.	PROPN
admet-194	362	10	thomas	thomas	PROPN
admet-194	362	11	,	,	PUNCT
admet-194	362	12	m.	m.	NOUN
admet-194	362	13	farlow	farlow	NOUN
admet-194	362	14	,	,	PUNCT
admet-194	362	15	t.	t.	PROPN
admet-194	362	16	iwatsubo	iwatsubo	PROPN
admet-194	362	17	,	,	PUNCT
admet-194	362	18	b.	b.	PROPN
admet-194	362	19	vellas	vellas	PROPN
admet-194	362	20	,	,	PUNCT
admet-194	362	21	s.	s.	PROPN
admet-194	362	22	joffe	joffe	PROPN
admet-194	362	23	,	,	PUNCT
admet-194	362	24	k.	k.	PROPN
admet-194	362	25	kieburtz	kieburtz	PROPN
admet-194	362	26	,	,	PUNCT
admet-194	362	27	r.	r.	PROPN
admet-194	362	28	raman	raman	PROPN
admet-194	362	29	,	,	PUNCT
admet-194	362	30	x.	x.	PROPN
admet-194	362	31	sun	sun	PROPN
admet-194	362	32	,	,	PUNCT
admet-194	362	33	p.s	p.s	PROPN
admet-194	362	34	.	.	PROPN
admet-194	362	35	aisen	aisen	PROPN
admet-194	362	36	,	,	PUNCT
admet-194	362	37	e.	e.	PROPN
admet-194	362	38	siemers	siemers	PROPN
admet-194	362	39	,	,	PUNCT
admet-194	362	40	h.	h.	PROPN
admet-194	362	41	liu	liu	PROPN
admet-194	362	42	-	-	PUNCT
admet-194	362	43	seifert	seifert	PROPN
admet-194	362	44	,	,	PUNCT
admet-194	362	45	r.	r.	PROPN
admet-194	362	46	mohs	mohs	PROPN
admet-194	362	47	;	;	PUNCT
admet-194	362	48	alzheimer	alzheimer	PROPN
admet-194	362	49	's	's	PART
admet-194	362	50	disease	disease	NOUN
admet-194	362	51	cooperative	cooperative	ADJ
admet-194	362	52	study	study	NOUN
admet-194	362	53	steering	steering	NOUN
admet-194	362	54	committee	committee	NOUN
admet-194	362	55	;	;	PUNCT
admet-194	362	56	solanezumab	solanezumab	NOUN
admet-194	362	57	study	study	NOUN
admet-194	362	58	group	group	NOUN
admet-194	362	59	.	.	PUNCT
admet-194	362	60	,	,	PUNCT
admet-194	362	61	new	new	PROPN
admet-194	362	62	england	england	PROPN
admet-194	362	63	journal	journal	PROPN
admet-194	362	64	of	of	ADP
admet-194	362	65	medicine	medicine	NOUN
admet-194	362	66	370	370	NUM
admet-194	362	67	(	(	PUNCT
admet-194	362	68	2014	2014	NUM
admet-194	362	69	)	)	PUNCT
admet-194	362	70	311	311	NUM
admet-194	362	71	-	-	SYM
admet-194	362	72	321	321	NUM
admet-194	362	73	.	.	PUNCT
admet-194	363	1	[	[	X
admet-194	363	2	61	61	NUM
admet-194	363	3	]	]	PUNCT
admet-194	363	4	b.	b.	PROPN
admet-194	363	5	bohrmann	bohrmann	PROPN
admet-194	363	6	,	,	PUNCT
admet-194	363	7	k.	k.	PROPN
admet-194	363	8	baumann	baumann	PROPN
admet-194	363	9	,	,	PUNCT
admet-194	363	10	j.	j.	PROPN
admet-194	363	11	benz	benz	PROPN
admet-194	363	12	,	,	PUNCT
admet-194	363	13	f.	f.	PROPN
admet-194	363	14	gerber	gerber	PROPN
admet-194	363	15	,	,	PUNCT
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admet-194	363	19	f.	f.	PROPN
admet-194	363	20	knoflach	knoflach	PROPN
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admet-194	363	22	j.	j.	PROPN
admet-194	363	23	messer	messer	PROPN
admet-194	363	24	,	,	PUNCT
admet-194	363	25	k.	k.	PROPN
admet-194	363	26	oroszlan	oroszlan	PROPN
admet-194	363	27	,	,	PUNCT
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admet-194	363	30	,	,	PUNCT
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admet-194	363	32	.	.	PROPN
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admet-194	363	34	,	,	PUNCT
admet-194	363	35	c.	c.	PROPN
admet-194	363	36	rothe	rothe	PROPN
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admet-194	363	40	,	,	PUNCT
admet-194	363	41	m.	m.	NOUN
admet-194	363	42	bardroff	bardroff	PROPN
admet-194	363	43	,	,	PUNCT
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admet-194	363	46	,	,	PUNCT
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admet-194	363	49	,	,	PUNCT
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admet-194	363	52	,	,	PUNCT
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admet-194	363	59	(	(	PUNCT
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admet-194	363	61	)	)	PUNCT
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admet-194	363	63	-	-	SYM
admet-194	363	64	69	69	NUM
admet-194	363	65	.	.	PUNCT
admet-194	364	1	[	[	X
admet-194	364	2	62	62	NUM
admet-194	364	3	]	]	PUNCT
admet-194	364	4	a	a	DET
admet-194	364	5	study	study	NOUN
admet-194	364	6	of	of	ADP
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admet-194	364	8	in	in	ADP
admet-194	364	9	patients	patient	NOUN
admet-194	364	10	with	with	ADP
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admet-194	364	12	alzheimer	alzheimer	NOUN
admet-194	364	13	disease	disease	NOUN
admet-194	364	14	,	,	PUNCT
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admet-194	364	20	)	)	PUNCT
admet-194	364	21	.	.	PUNCT
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admet-194	365	4	j.w	j.w	PROPN
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admet-194	365	8	q.	q.	PROPN
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admet-194	365	11	s.	s.	PROPN
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admet-194	365	13	,	,	PUNCT
admet-194	365	14	m.	m.	NOUN
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admet-194	365	17	m.	m.	PROPN
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admet-194	365	19	,	,	PUNCT
admet-194	365	20	c.b	c.b	PROPN
admet-194	365	21	.	.	PROPN
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admet-194	365	28	c.	c.	PROPN
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admet-194	365	34	j.	j.	PROPN
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admet-194	365	36	,	,	PUNCT
admet-194	365	37	j.w	j.w	PROPN
admet-194	365	38	.	.	PROPN
admet-194	365	39	kupiec	kupiec	PROPN
admet-194	365	40	,	,	PUNCT
admet-194	365	41	m.m	m.m	PROPN
admet-194	365	42	.	.	PROPN
admet-194	365	43	bednar	bednar	PROPN
admet-194	365	44	,	,	PUNCT
admet-194	365	45	clinical	clinical	ADJ
admet-194	365	46	neuropharmacology	neuropharmacology	NOUN
admet-194	365	47	36	36	NUM
admet-194	365	48	(	(	PUNCT
admet-194	365	49	2013	2013	NUM
admet-194	365	50	)	)	PUNCT
admet-194	365	51	14	14	NUM
admet-194	365	52	-	-	SYM
admet-194	365	53	23	23	NUM
admet-194	365	54	.	.	PUNCT
admet-194	366	1	[	[	X
admet-194	366	2	64	64	NUM
admet-194	366	3	]	]	X
admet-194	366	4	ponezumab	ponezumab	NOUN
admet-194	366	5	,	,	PUNCT
admet-194	366	6	http://www.alzforum.org/therapeutics/ponezumab	http://www.alzforum.org/therapeutics/ponezumab	NOUN
admet-194	366	7	(	(	PUNCT
admet-194	366	8	2015	2015	NUM
admet-194	366	9	)	)	PUNCT
admet-194	366	10	.	.	PUNCT
admet-194	367	1	[	[	X
admet-194	367	2	65	65	NUM
admet-194	367	3	]	]	X
admet-194	367	4	t.	t.	PROPN
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admet-194	367	6	,	,	PUNCT
admet-194	367	7	n.	n.	PROPN
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admet-194	367	9	,	,	PUNCT
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admet-194	367	20	,	,	PUNCT
admet-194	367	21	x.	x.	PROPN
admet-194	367	22	tong	tong	PROPN
admet-194	367	23	,	,	PUNCT
admet-194	367	24	a.	a.	PROPN
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admet-194	367	26	,	,	PUNCT
admet-194	367	27	s.	s.	PROPN
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admet-194	367	29	,	,	PUNCT
admet-194	367	30	a.	a.	NOUN
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admet-194	367	32	,	,	PUNCT
admet-194	367	33	m.	m.	NOUN
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admet-194	367	36	c.	c.	PROPN
admet-194	367	37	hottenstein	hottenstein	PROPN
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admet-194	367	39	h.	h.	PROPN
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admet-194	367	47	,	,	PUNCT
admet-194	367	48	alzheimer	alzheimer	PROPN
admet-194	367	49	’s	’s	PART
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admet-194	367	51	and	and	CCONJ
admet-194	367	52	therapy	therapy	NOUN
admet-194	367	53	6	6	NUM
admet-194	367	54	(	(	PUNCT
admet-194	367	55	2014	2014	NUM
admet-194	367	56	)	)	PUNCT
admet-194	367	57	19	19	NUM
admet-194	367	58	.	.	PUNCT
admet-194	368	1	[	[	X
admet-194	368	2	66	66	NUM
admet-194	368	3	]	]	X
admet-194	368	4	n.	n.	NOUN
admet-194	368	5	andreasen	andreasen	PROPN
admet-194	368	6	,	,	PUNCT
admet-194	368	7	m.	m.	NOUN
admet-194	368	8	simeoni	simeoni	NOUN
admet-194	368	9	,	,	PUNCT
admet-194	368	10	h.	h.	PROPN
admet-194	368	11	ostlund	ostlund	PROPN
admet-194	368	12	,	,	PUNCT
admet-194	368	13	p.i	p.i	PROPN
admet-194	368	14	.	.	PROPN
admet-194	368	15	lisjo	lisjo	PROPN
admet-194	368	16	,	,	PUNCT
admet-194	368	17	t.	t.	NOUN
admet-194	368	18	fladby	fladby	NOUN
admet-194	368	19	,	,	PUNCT
admet-194	368	20	a.e	a.e	PROPN
admet-194	368	21	.	.	PROPN
admet-194	368	22	loercher	loercher	PROPN
admet-194	368	23	,	,	PUNCT
admet-194	368	24	g.j	g.j	PROPN
admet-194	368	25	.	.	PROPN
admet-194	368	26	byrne	byrne	PROPN
admet-194	368	27	,	,	PUNCT
admet-194	368	28	f.	f.	PROPN
admet-194	368	29	murray	murray	PROPN
admet-194	368	30	,	,	PUNCT
admet-194	368	31	p.t	p.t	PROPN
admet-194	368	32	.	.	PROPN
admet-194	368	33	scott	scott	PROPN
admet-194	368	34	-	-	PUNCT
admet-194	368	35	stevens	stevens	PROPN
admet-194	368	36	,	,	PUNCT
admet-194	368	37	a.	a.	NOUN
admet-194	368	38	wallin	wallin	PROPN
admet-194	368	39	,	,	PUNCT
admet-194	368	40	y.y	y.y	PROPN
admet-194	368	41	.	.	PROPN
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admet-194	368	43	,	,	PUNCT
admet-194	368	44	l.h	l.h	PROPN
admet-194	368	45	.	.	PROPN
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admet-194	368	47	,	,	PUNCT
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admet-194	368	50	,	,	PUNCT
admet-194	368	51	a.k	a.k	PROPN
admet-194	368	52	.	.	PROPN
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admet-194	368	54	,	,	PUNCT
admet-194	368	55	a.j	a.j	PROPN
admet-194	368	56	.	.	PROPN
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admet-194	368	58	,	,	PUNCT
admet-194	368	59	s.a	s.a	PROPN
admet-194	368	60	.	.	PROPN
admet-194	368	61	khan	khan	PROPN
admet-194	368	62	,	,	PUNCT
admet-194	368	63	j.	j.	PROPN
admet-194	368	64	hilpert	hilpert	PROPN
admet-194	368	65	,	,	PUNCT
admet-194	368	66	p.c	p.c	PROPN
admet-194	368	67	.	.	PROPN
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admet-194	368	69	,	,	PUNCT
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admet-194	368	71	one	one	NUM
admet-194	368	72	10	10	NUM
admet-194	368	73	(	(	PUNCT
admet-194	368	74	2015	2015	NUM
admet-194	368	75	)	)	PUNCT
admet-194	368	76	e0098153	e0098153	PROPN
admet-194	368	77	.	.	PUNCT
admet-194	369	1	[	[	X
admet-194	369	2	67	67	NUM
admet-194	369	3	]	]	X
admet-194	369	4	r.	r.	PROPN
admet-194	369	5	dodel	dodel	PROPN
admet-194	369	6	,	,	PUNCT
admet-194	369	7	f.	f.	PROPN
admet-194	369	8	neff	neff	PROPN
admet-194	369	9	,	,	PUNCT
admet-194	369	10	c.	c.	PROPN
admet-194	369	11	noelker	noelker	PROPN
admet-194	369	12	,	,	PUNCT
admet-194	369	13	r.	r.	PROPN
admet-194	369	14	pul	pul	PROPN
admet-194	369	15	,	,	PUNCT
admet-194	369	16	y.	y.	PROPN
admet-194	369	17	du	du	PROPN
admet-194	369	18	,	,	PUNCT
admet-194	369	19	m.	m.	NOUN
admet-194	369	20	bacher	bacher	PROPN
admet-194	369	21	,	,	PUNCT
admet-194	369	22	w.	w.	PROPN
admet-194	369	23	oertel	oertel	PROPN
admet-194	369	24	,	,	PUNCT
admet-194	369	25	drugs	drug	NOUN
admet-194	369	26	70	70	NUM
admet-194	369	27	(	(	PUNCT
admet-194	369	28	2010	2010	NUM
admet-194	369	29	)	)	PUNCT
admet-194	369	30	513	513	NUM
admet-194	369	31	-	-	SYM
admet-194	369	32	528	528	NUM
admet-194	369	33	.	.	PUNCT
admet-194	370	1	[	[	X
admet-194	370	2	68	68	NUM
admet-194	370	3	]	]	X
admet-194	370	4	k.g	k.g	PROPN
admet-194	370	5	.	.	PROPN
admet-194	370	6	mawuenyega	mawuenyega	PROPN
admet-194	370	7	,	,	PUNCT
admet-194	370	8	w.	w.	PROPN
admet-194	370	9	sigurdson	sigurdson	PROPN
admet-194	370	10	,	,	PUNCT
admet-194	370	11	v.	v.	CCONJ
admet-194	370	12	ovod	ovod	PROPN
admet-194	370	13	,	,	PUNCT
admet-194	370	14	l.	l.	PROPN
admet-194	370	15	munsell	munsell	PROPN
admet-194	370	16	,	,	PUNCT
admet-194	370	17	t.	t.	PROPN
admet-194	370	18	kasten	kasten	PROPN
admet-194	370	19	,	,	PUNCT
admet-194	370	20	j.c	j.c	PROPN
admet-194	370	21	.	.	PROPN
admet-194	370	22	morris	morris	PROPN
admet-194	370	23	,	,	PUNCT
admet-194	370	24	k.e	k.e	PROPN
admet-194	370	25	.	.	PROPN
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admet-194	370	27	,	,	PUNCT
admet-194	370	28	r.j	r.j	PROPN
admet-194	370	29	.	.	PROPN
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admet-194	370	31	,	,	PUNCT
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admet-194	370	33	330	330	NUM
admet-194	370	34	(	(	PUNCT
admet-194	370	35	2010	2010	NUM
admet-194	370	36	)	)	PUNCT
admet-194	370	37	1774	1774	NUM
admet-194	370	38	.	.	PUNCT
admet-194	371	1	[	[	X
admet-194	371	2	69	69	NUM
admet-194	371	3	]	]	PUNCT
admet-194	371	4	s.	s.	PROPN
admet-194	371	5	d.	d.	PROPN
admet-194	371	6	mulder	mulder	PROPN
admet-194	371	7	,	,	PUNCT
admet-194	371	8	r.	r.	PROPN
admet-194	371	9	veerhuis	veerhuis	PROPN
admet-194	371	10	,	,	PUNCT
admet-194	371	11	m.	m.	NOUN
admet-194	371	12	a.	a.	NOUN
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admet-194	371	14	,	,	PUNCT
admet-194	371	15	h.	h.	PROPN
admet-194	371	16	m.	m.	PROPN
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admet-194	371	18	,	,	PUNCT
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admet-194	371	22	(	(	PUNCT
admet-194	371	23	2012	2012	NUM
admet-194	371	24	)	)	PUNCT
admet-194	371	25	373379	373379	NUM
admet-194	371	26	.	.	PUNCT
admet-194	372	1	[	[	X
admet-194	372	2	70	70	NUM
admet-194	372	3	]	]	X
admet-194	372	4	c.	c.	PROPN
admet-194	372	5	bauer	bauer	PROPN
admet-194	372	6	,	,	PUNCT
admet-194	372	7	r.	r.	PROPN
admet-194	372	8	pardossi	pardossi	NOUN
admet-194	372	9	-	-	PUNCT
admet-194	372	10	piquard	piquard	NOUN
admet-194	372	11	,	,	PUNCT
admet-194	372	12	j.	j.	PROPN
admet-194	372	13	dunys	dunys	PROPN
admet-194	372	14	,	,	PUNCT
admet-194	372	15	m.	m.	PROPN
admet-194	372	16	roy	roy	PROPN
admet-194	372	17	,	,	PUNCT
admet-194	372	18	f.	f.	PROPN
admet-194	372	19	checler	checler	PROPN
admet-194	372	20	,	,	PUNCT
admet-194	372	21	journal	journal	NOUN
admet-194	372	22	of	of	ADP
admet-194	372	23	alzheimer	alzheimer	PROPN
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admet-194	372	25	disease	disease	NOUN
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admet-194	372	27	(	(	PUNCT
admet-194	372	28	2011	2011	NUM
admet-194	372	29	)	)	PUNCT
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admet-194	372	31	-	-	SYM
admet-194	372	32	520	520	NUM
admet-194	372	33	.	.	PUNCT
admet-194	373	1	[	[	X
admet-194	373	2	71	71	NUM
admet-194	373	3	]	]	X
admet-194	373	4	n.n	n.n	PROPN
admet-194	373	5	.	.	PROPN
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admet-194	373	7	,	,	PUNCT
admet-194	373	8	n.d	n.d	PROPN
admet-194	373	9	.	.	PROPN
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admet-194	373	11	,	,	PUNCT
admet-194	373	12	d.i	d.i	PROPN
admet-194	373	13	.	.	PROPN
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admet-194	373	15	,	,	PUNCT
admet-194	373	16	a.r	a.r	PROPN
admet-194	373	17	.	.	PROPN
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admet-194	373	19	,	,	PUNCT
admet-194	373	20	n.z	n.z	PROPN
admet-194	373	21	.	.	PROPN
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admet-194	373	23	,	,	PUNCT
admet-194	373	24	d.i	d.i	PROPN
admet-194	373	25	.	.	PROPN
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admet-194	373	27	,	,	PUNCT
admet-194	373	28	n.m	n.m	PROPN
admet-194	373	29	.	.	PROPN
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admet-194	373	31	,	,	PUNCT
admet-194	373	32	s.a	s.a	PROPN
admet-194	373	33	.	.	PROPN
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admet-194	373	35	,	,	PUNCT
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admet-194	373	37	.	.	PROPN
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admet-194	373	39	,	,	PUNCT
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admet-194	373	41	.	.	PROPN
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admet-194	373	43	,	,	PUNCT
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admet-194	373	49	(	(	PUNCT
admet-194	373	50	2012	2012	NUM
admet-194	373	51	)	)	PUNCT
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admet-194	373	53	-	-	SYM
admet-194	373	54	577	577	NUM
admet-194	373	55	.	.	PUNCT
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admet-194	374	3	]	]	X
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admet-194	374	6	,	,	PUNCT
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admet-194	374	8	i.	i.	PROPN
admet-194	374	9	c.	c.	PROPN
admet-194	374	10	scopes	scopes	PROPN
admet-194	374	11	,	,	PUNCT
admet-194	374	12	journal	journal	NOUN
admet-194	374	13	of	of	ADP
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admet-194	374	15	disease	disease	NOUN
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admet-194	374	17	(	(	PUNCT
admet-194	374	18	2009	2009	NUM
admet-194	374	19	)	)	PUNCT
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admet-194	374	21	-	-	SYM
admet-194	374	22	47	47	NUM
admet-194	374	23	.	.	PUNCT
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admet-194	375	3	]	]	X
admet-194	375	4	p.a	p.a	PROPN
admet-194	375	5	.	.	PROPN
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admet-194	375	7	,	,	PUNCT
admet-194	375	8	r.a	r.a	PROPN
admet-194	375	9	.	.	PROPN
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admet-194	375	11	,	,	PUNCT
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admet-194	375	13	.	.	PROPN
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admet-194	375	15	,	,	PUNCT
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admet-194	375	19	e.	e.	PROPN
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admet-194	375	21	,	,	PUNCT
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admet-194	375	23	cortes	corte	NOUN
admet-194	375	24	,	,	PUNCT
admet-194	375	25	i.	i.	PROPN
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admet-194	375	37	,	,	PUNCT
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admet-194	375	41	q.x	q.x	PROPN
admet-194	375	42	.	.	PROPN
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admet-194	375	44	,	,	PUNCT
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admet-194	375	46	.	.	PROPN
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admet-194	375	48	,	,	PUNCT
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admet-194	375	50	.	.	PROPN
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admet-194	375	52	,	,	PUNCT
admet-194	375	53	s.	s.	PROPN
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admet-194	375	55	,	,	PUNCT
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admet-194	375	68	,	,	PUNCT
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admet-194	375	72	,	,	PUNCT
admet-194	375	73	r.	r.	PROPN
admet-194	375	74	cappai	cappai	PROPN
admet-194	375	75	,	,	PUNCT
admet-194	375	76	c.l	c.l	PROPN
admet-194	375	77	.	.	PROPN
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admet-194	375	79	,	,	PUNCT
admet-194	375	80	k.j	k.j	PROPN
admet-194	375	81	.	.	PUNCT
admet-194	375	82	barnham	barnham	PROPN
admet-194	375	83	,	,	PUNCT
admet-194	375	84	a.i	a.i	PROPN
admet-194	375	85	.	.	PROPN
admet-194	375	86	bush	bush	PROPN
admet-194	375	87	,	,	PUNCT
admet-194	375	88	neuron	neuron	VERB
admet-194	375	89	59	59	NUM
admet-194	375	90	(	(	PUNCT
admet-194	375	91	2008	2008	NUM
admet-194	375	92	)	)	PUNCT
admet-194	375	93	43	43	NUM
admet-194	375	94	-	-	SYM
admet-194	375	95	55	55	NUM
admet-194	375	96	.	.	PUNCT
admet-194	376	1	[	[	X
admet-194	376	2	74	74	NUM
admet-194	376	3	]	]	PUNCT
admet-194	376	4	there	there	PRON
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admet-194	376	8	that	that	SCONJ
admet-194	376	9	mpacs	mpac	NOUN
admet-194	376	10	(	(	PUNCT
admet-194	376	11	pbt1	pbt1	PROPN
admet-194	376	12	or	or	CCONJ
admet-194	376	13	pbt2	pbt2	NOUN
admet-194	376	14	)	)	PUNCT
admet-194	376	15	are	be	AUX
admet-194	376	16	of	of	ADP
admet-194	376	17	benefit	benefit	NOUN
admet-194	376	18	in	in	ADP
admet-194	376	19	alzheimer	alzheimer	PROPN
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admet-194	376	24	(	(	PUNCT
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admet-194	376	29	)	)	PUNCT
admet-194	376	30	.	.	PUNCT
admet-194	377	1	[	[	X
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admet-194	377	3	]	]	X
admet-194	377	4	pbt2	pbt2	NOUN
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admet-194	377	6	a	a	DET
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admet-194	377	8	in	in	ADP
admet-194	377	9	phase	phase	NOUN
admet-194	377	10	2	2	NUM
admet-194	377	11	alzheimer	alzheimer	NOUN
admet-194	377	12	's	's	PART
admet-194	377	13	trial	trial	NOUN
admet-194	377	14	,	,	PUNCT
admet-194	377	15	http://www.alzforum.org/news/research-news/pbt2takes-dive-phase-2-alzheimers-trial	http://www.alzforum.org/news/research-news/pbt2takes-dive-phase-2-alzheimers-trial	PROPN
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admet-194	378	66	)	)	PUNCT
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admet-194	378	68	-	-	SYM
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admet-194	378	70	.	.	PUNCT
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admet-194	379	3	]	]	X
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admet-194	379	9	,	,	PUNCT
admet-194	379	10	j.w	j.w	PROPN
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admet-194	379	13	,	,	PUNCT
admet-194	379	14	s.	s.	PROPN
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admet-194	379	16	,	,	PUNCT
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admet-194	379	18	.	.	PROPN
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admet-194	379	21	y.	y.	PROPN
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admet-194	379	32	-	-	PUNCT
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admet-194	379	38	,	,	PUNCT
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admet-194	379	41	,	,	PUNCT
admet-194	379	42	j.j	j.j	PROPN
admet-194	379	43	.	.	PROPN
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admet-194	379	45	,	,	PUNCT
admet-194	379	46	j.v	j.v	PROPN
admet-194	379	47	.	.	PROPN
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admet-194	379	49	,	,	PUNCT
admet-194	379	50	l.	l.	PROPN
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admet-194	379	52	,	,	PUNCT
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admet-194	379	56	(	(	PUNCT
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admet-194	379	58	)	)	PUNCT
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admet-194	379	60	-	-	SYM
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admet-194	379	62	.	.	PUNCT
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admet-194	380	7	,	,	PUNCT
admet-194	380	8	k.	k.	PROPN
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admet-194	380	10	-	-	PUNCT
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admet-194	380	13	j.j	j.j	PROPN
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admet-194	380	16	,	,	PUNCT
admet-194	380	17	f.	f.	PROPN
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admet-194	380	19	,	,	PUNCT
admet-194	380	20	i.h	i.h	PROPN
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admet-194	380	36	,	,	PUNCT
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admet-194	380	39	(	(	PUNCT
admet-194	380	40	2007	2007	NUM
admet-194	380	41	)	)	PUNCT
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admet-194	380	43	-	-	SYM
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admet-194	380	45	.	.	PUNCT
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admet-194	381	19	)	)	PUNCT
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admet-194	381	21	-	-	SYM
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admet-194	381	23	.	.	PUNCT
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admet-194	382	43	-	-	SYM
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admet-194	384	15	)	)	PUNCT
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admet-194	384	17	-	-	SYM
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admet-194	385	14	(	(	PUNCT
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admet-194	385	18	-	-	SYM
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admet-194	385	20	.	.	PUNCT
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admet-194	386	19	)	)	PUNCT
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admet-194	386	21	-	-	SYM
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admet-194	390	10	,	,	PUNCT
admet-194	390	11	j.	j.	PROPN
admet-194	390	12	cummings	cummings	PROPN
admet-194	390	13	,	,	PUNCT
admet-194	390	14	l.	l.	PROPN
admet-194	390	15	jakimovich	jakimovich	PROPN
admet-194	390	16	,	,	PUNCT
admet-194	390	17	l.	l.	PROPN
admet-194	390	18	schneider	schneider	PROPN
admet-194	390	19	,	,	PUNCT
admet-194	390	20	r.	r.	PROPN
admet-194	390	21	thomas	thomas	PROPN
admet-194	390	22	,	,	PUNCT
admet-194	390	23	l.	l.	PROPN
admet-194	390	24	becerra	becerra	PROPN
admet-194	390	25	,	,	PUNCT
admet-194	390	26	r.	r.	PROPN
admet-194	390	27	loy	loy	PROPN
admet-194	390	28	,	,	PUNCT
admet-194	390	29	alzheimer	alzheimer	PROPN
admet-194	390	30	’s	’s	PART
admet-194	390	31	&	&	CCONJ
admet-194	390	32	dementia	dementia	PROPN
admet-194	390	33	5	5	NUM
admet-194	390	34	(	(	PUNCT
admet-194	390	35	2009	2009	NUM
admet-194	390	36	)	)	PUNCT
admet-194	390	37	84–85	84–85	NUM
admet-194	390	38	.	.	PUNCT
admet-194	391	1	[	[	X
admet-194	391	2	87	87	NUM
admet-194	391	3	]	]	PUNCT
admet-194	391	4	a.	a.	NOUN
admet-194	391	5	martinez	martinez	PROPN
admet-194	391	6	,	,	PUNCT
admet-194	391	7	d.	d.	PROPN
admet-194	391	8	i.	i.	PROPN
admet-194	391	9	perez	perez	PROPN
admet-194	391	10	,	,	PUNCT
admet-194	391	11	journal	journal	NOUN
admet-194	391	12	of	of	ADP
admet-194	391	13	alzheimers	alzheimers	PROPN
admet-194	391	14	disease	disease	NOUN
admet-194	391	15	15	15	NUM
admet-194	391	16	(	(	PUNCT
admet-194	391	17	2008	2008	NUM
admet-194	391	18	)	)	PUNCT
admet-194	391	19	181	181	NUM
admet-194	391	20	-	-	SYM
admet-194	391	21	191	191	NUM
admet-194	391	22	.	.	PUNCT
admet-194	392	1	[	[	X
admet-194	392	2	88	88	NUM
admet-194	392	3	]	]	PUNCT
admet-194	392	4	a.	a.	NOUN
admet-194	392	5	caccamo	caccamo	PROPN
admet-194	392	6	,	,	PUNCT
admet-194	392	7	s.	s.	PROPN
admet-194	392	8	oddo	oddo	PROPN
admet-194	392	9	,	,	PUNCT
admet-194	392	10	l.	l.	PROPN
admet-194	392	11	x.	x.	PROPN
admet-194	392	12	tran	tran	PROPN
admet-194	392	13	,	,	PUNCT
admet-194	392	14	f.	f.	PROPN
admet-194	392	15	m.	m.	PROPN
admet-194	392	16	laferla	laferla	PROPN
admet-194	392	17	,	,	PUNCT
admet-194	392	18	american	american	ADJ
admet-194	392	19	journal	journal	PROPN
admet-194	392	20	of	of	ADP
admet-194	392	21	pathology	pathology	PROPN
admet-194	392	22	170	170	NUM
admet-194	392	23	(	(	PUNCT
admet-194	392	24	2007	2007	NUM
admet-194	392	25	)	)	PUNCT
admet-194	392	26	1669	1669	NUM
admet-194	392	27	-	-	SYM
admet-194	392	28	1675	1675	NUM
admet-194	392	29	.	.	PUNCT
admet-194	393	1	[	[	X
admet-194	393	2	89	89	NUM
admet-194	393	3	]	]	PUNCT
admet-194	393	4	h.	h.	PROPN
admet-194	393	5	hampel	hampel	PROPN
admet-194	393	6	,	,	PUNCT
admet-194	393	7	m.	m.	NOUN
admet-194	393	8	ewers	ewer	NOUN
admet-194	393	9	,	,	PUNCT
admet-194	393	10	k.	k.	NOUN
admet-194	393	11	bürger	bürger	PROPN
admet-194	393	12	,	,	PUNCT
admet-194	393	13	p.	p.	NOUN
admet-194	393	14	annas	annas	PROPN
admet-194	393	15	,	,	PUNCT
admet-194	393	16	a.	a.	PROPN
admet-194	393	17	mörtberg	mörtberg	PROPN
admet-194	393	18	,	,	PUNCT
admet-194	393	19	a.	a.	PROPN
admet-194	393	20	bogstedt	bogstedt	PROPN
admet-194	393	21	,	,	PUNCT
admet-194	393	22	l.	l.	PROPN
admet-194	393	23	frölich	frölich	PROPN
admet-194	393	24	,	,	PUNCT
admet-194	393	25	j.	j.	PROPN
admet-194	393	26	schröder	schröder	PROPN
admet-194	393	27	,	,	PUNCT
admet-194	393	28	p.	p.	NOUN
admet-194	393	29	schönknecht	schönknecht	PROPN
admet-194	393	30	,	,	PUNCT
admet-194	393	31	m.w	m.w	PROPN
admet-194	393	32	.	.	PROPN
admet-194	393	33	riepe	riepe	PROPN
admet-194	393	34	,	,	PUNCT
admet-194	393	35	i.	i.	NOUN
admet-194	393	36	kraft	kraft	PROPN
admet-194	393	37	,	,	PUNCT
admet-194	393	38	t.	t.	NOUN
admet-194	393	39	gasser	gasser	NOUN
admet-194	393	40	,	,	PUNCT
admet-194	393	41	t.	t.	PROPN
admet-194	393	42	leyhe	leyhe	PROPN
admet-194	393	43	,	,	PUNCT
admet-194	393	44	h.j	h.j	PROPN
admet-194	393	45	.	.	PROPN
admet-194	393	46	möller	möller	PROPN
admet-194	393	47	,	,	PUNCT
admet-194	393	48	h.	h.	PROPN
admet-194	393	49	basun	basun	PROPN
admet-194	393	50	,	,	PUNCT
admet-194	393	51	journal	journal	NOUN
admet-194	393	52	of	of	ADP
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admet-194	393	54	psychiatry	psychiatry	NOUN
admet-194	393	55	70	70	NUM
admet-194	393	56	(	(	PUNCT
admet-194	393	57	2009	2009	NUM
admet-194	393	58	)	)	PUNCT
admet-194	393	59	922	922	NUM
admet-194	393	60	-	-	NUM
admet-194	393	61	931	931	NUM
admet-194	393	62	.	.	PUNCT
admet-194	394	1	[	[	X
admet-194	394	2	90	90	NUM
admet-194	394	3	]	]	PUNCT
admet-194	394	4	w.	w.	PROPN
admet-194	394	5	noble	noble	PROPN
admet-194	394	6	,	,	PUNCT
admet-194	394	7	v.	v.	CCONJ
admet-194	394	8	olm	olm	PROPN
admet-194	394	9	,	,	PUNCT
admet-194	394	10	k.	k.	PROPN
admet-194	394	11	takata	takata	PROPN
admet-194	394	12	,	,	PUNCT
admet-194	394	13	e.	e.	PROPN
admet-194	394	14	casey	casey	PROPN
admet-194	394	15	,	,	PUNCT
admet-194	394	16	o.	o.	PROPN
admet-194	394	17	mary	mary	PROPN
admet-194	394	18	,	,	PUNCT
admet-194	394	19	j.	j.	PROPN
admet-194	394	20	meyerson	meyerson	PROPN
admet-194	394	21	,	,	PUNCT
admet-194	394	22	k.	k.	PROPN
admet-194	394	23	gaynor	gaynor	PROPN
admet-194	394	24	,	,	PUNCT
admet-194	394	25	j.	j.	PROPN
admet-194	394	26	lafrancois	lafrancois	PROPN
admet-194	394	27	,	,	PUNCT
admet-194	394	28	l.	l.	PROPN
admet-194	394	29	wang	wang	PROPN
admet-194	394	30	,	,	PUNCT
admet-194	394	31	t.	t.	PROPN
admet-194	394	32	kondo	kondo	PROPN
admet-194	394	33	,	,	PUNCT
admet-194	394	34	p.	p.	PROPN
admet-194	394	35	davies	davy	NOUN
admet-194	394	36	,	,	PUNCT
admet-194	394	37	m.	m.	NOUN
admet-194	394	38	burns	burn	NOUN
admet-194	394	39	,	,	PUNCT
admet-194	394	40	a.	a.	NOUN
admet-194	394	41	veer	veer	NOUN
admet-194	394	42	,	,	PUNCT
admet-194	394	43	r.	r.	PROPN
admet-194	394	44	nixon	nixon	PROPN
admet-194	394	45	,	,	PUNCT
admet-194	394	46	d.	d.	PROPN
admet-194	394	47	dickson	dickson	PROPN
admet-194	394	48	,	,	PUNCT
admet-194	394	49	y.	y.	PROPN
admet-194	394	50	matsuoka	matsuoka	PROPN
admet-194	394	51	,	,	PUNCT
admet-194	394	52	m.	m.	NOUN
admet-194	394	53	ahlijanian	ahlijanian	PROPN
admet-194	394	54	,	,	PUNCT
admet-194	394	55	l.f	l.f	PROPN
admet-194	394	56	.	.	PROPN
admet-194	394	57	lau	lau	PROPN
admet-194	394	58	,	,	PUNCT
admet-194	394	59	k.	k.	PROPN
admet-194	394	60	duff	duff	PROPN
admet-194	394	61	,	,	PUNCT
admet-194	394	62	neuron	neuron	VERB
admet-194	394	63	38	38	NUM
admet-194	394	64	(	(	PUNCT
admet-194	394	65	2003	2003	NUM
admet-194	394	66	)	)	PUNCT
admet-194	394	67	555	555	NUM
admet-194	394	68	-	-	SYM
admet-194	394	69	565	565	NUM
admet-194	394	70	.	.	PUNCT
admet-194	395	1	[	[	X
admet-194	395	2	91	91	X
admet-194	395	3	]	]	X
admet-194	395	4	y.	y.	NOUN
admet-194	395	5	choi	choi	PROPN
admet-194	395	6	,	,	PUNCT
admet-194	395	7	h.s	h.s	PROPN
admet-194	395	8	.	.	PROPN
admet-194	395	9	kim	kim	PROPN
admet-194	395	10	,	,	PUNCT
admet-194	395	11	k.y	k.y	PROPN
admet-194	395	12	.	.	PROPN
admet-194	395	13	shin	shin	PROPN
admet-194	395	14	,	,	PUNCT
admet-194	395	15	e.m	e.m	PROPN
admet-194	395	16	.	.	PROPN
admet-194	395	17	kim	kim	PROPN
admet-194	395	18	,	,	PUNCT
admet-194	395	19	m.	m.	PROPN
admet-194	395	20	kim	kim	PROPN
admet-194	395	21	,	,	PUNCT
admet-194	395	22	h.s	h.s	PROPN
admet-194	395	23	.	.	PROPN
admet-194	395	24	kim	kim	PROPN
admet-194	395	25	,	,	PUNCT
admet-194	395	26	c.h	c.h	PROPN
admet-194	395	27	.	.	PROPN
admet-194	395	28	park	park	PROPN
admet-194	395	29	,	,	PUNCT
admet-194	395	30	y.h	y.h	PROPN
admet-194	395	31	.	.	PROPN
admet-194	395	32	jeong	jeong	PROPN
admet-194	395	33	,	,	PUNCT
admet-194	395	34	j.	j.	PROPN
admet-194	395	35	yoo	yoo	PROPN
admet-194	395	36	,	,	PUNCT
admet-194	395	37	j.p	j.p	PROPN
admet-194	395	38	.	.	PROPN
admet-194	395	39	lee	lee	PROPN
admet-194	395	40	,	,	PUNCT
admet-194	395	41	k.a	k.a	PROPN
admet-194	395	42	.	.	PROPN
admet-194	395	43	chang	chang	PROPN
admet-194	395	44	,	,	PUNCT
admet-194	395	45	s.	s.	PROPN
admet-194	395	46	kim	kim	PROPN
admet-194	395	47	,	,	PUNCT
admet-194	395	48	y.h	y.h	PROPN
admet-194	395	49	.	.	PROPN
admet-194	395	50	suh	suh	PROPN
admet-194	395	51	,	,	PUNCT
admet-194	395	52	neuropsychopharmacology	neuropsychopharmacology	PROPN
admet-194	395	53	32	32	NUM
admet-194	395	54	(	(	PUNCT
admet-194	395	55	2007	2007	NUM
admet-194	395	56	)	)	PUNCT
admet-194	395	57	2393	2393	NUM
admet-194	395	58	-	-	SYM
admet-194	395	59	2404	2404	NUM
admet-194	395	60	.	.	PUNCT
admet-194	396	1	[	[	X
admet-194	396	2	92	92	NUM
admet-194	396	3	]	]	PUNCT
admet-194	396	4	m.	m.	NOUN
admet-194	396	5	pickhardt	pickhardt	NOUN
admet-194	396	6	,	,	PUNCT
admet-194	396	7	z.	z.	PROPN
admet-194	396	8	gazova	gazova	PROPN
admet-194	396	9	,	,	PUNCT
admet-194	396	10	m.	m.	PROPN
admet-194	396	11	von	von	PROPN
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admet-194	396	13	,	,	PUNCT
admet-194	396	14	i.	i.	PROPN
admet-194	396	15	khlistunova	khlistunova	PROPN
admet-194	396	16	,	,	PUNCT
admet-194	396	17	y.	y.	PROPN
admet-194	396	18	wang	wang	PROPN
admet-194	396	19	,	,	PUNCT
admet-194	396	20	a.	a.	NOUN
admet-194	396	21	hascher	hascher	PROPN
admet-194	396	22	,	,	PUNCT
admet-194	396	23	e.m	e.m	PROPN
admet-194	396	24	.	.	PROPN
admet-194	396	25	mandelkow	mandelkow	PROPN
admet-194	396	26	,	,	PUNCT
admet-194	396	27	j.	j.	PROPN
admet-194	396	28	biernat	biernat	PROPN
admet-194	396	29	,	,	PUNCT
admet-194	396	30	e.	e.	PROPN
admet-194	396	31	mandelkow	mandelkow	PROPN
admet-194	396	32	,	,	PUNCT
admet-194	396	33	journal	journal	NOUN
admet-194	396	34	of	of	ADP
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admet-194	396	37	280	280	NUM
admet-194	396	38	(	(	PUNCT
admet-194	396	39	2005	2005	NUM
admet-194	396	40	)	)	PUNCT
admet-194	396	41	3628	3628	NUM
admet-194	396	42	-	-	SYM
admet-194	396	43	363	363	NUM
admet-194	396	44	.	.	PUNCT
admet-194	397	1	[	[	X
admet-194	397	2	93	93	NUM
admet-194	397	3	]	]	PUNCT
admet-194	397	4	c.	c.	NOUN
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admet-194	397	6	,	,	PUNCT
admet-194	397	7	k.r	k.r	PROPN
admet-194	397	8	.	.	PROPN
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admet-194	397	10	,	,	PUNCT
admet-194	397	11	j.q	j.q	PROPN
admet-194	397	12	.	.	PROPN
admet-194	397	13	trojanowski	trojanowski	PROPN
admet-194	397	14	,	,	PUNCT
admet-194	397	15	v.m	v.m	PROPN
admet-194	397	16	.	.	PROPN
admet-194	397	17	lee	lee	PROPN
admet-194	397	18	,	,	PUNCT
admet-194	397	19	a.b	a.b	PROPN
admet-194	397	20	.	.	PROPN
admet-194	397	21	smith	smith	PROPN
admet-194	397	22	3rd	3rd	PROPN
admet-194	397	23	,	,	PUNCT
admet-194	397	24	d.m	d.m	PROPN
admet-194	397	25	.	.	PUNCT
admet-194	397	26	huryn	huryn	PROPN
admet-194	397	27	,	,	PUNCT
admet-194	397	28	current	current	ADJ
admet-194	397	29	topics	topic	NOUN
admet-194	397	30	in	in	ADP
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admet-194	397	32	chemistry	chemistry	NOUN
admet-194	397	33	11	11	NUM
admet-194	397	34	(	(	PUNCT
admet-194	397	35	2011	2011	NUM
admet-194	397	36	)	)	PUNCT
admet-194	397	37	317	317	NUM
admet-194	397	38	-	-	SYM
admet-194	397	39	330	330	NUM
admet-194	397	40	.	.	PUNCT
admet-194	398	1	[	[	X
admet-194	398	2	94	94	X
admet-194	398	3	]	]	X
admet-194	398	4	f.	f.	PROPN
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admet-194	398	6	,	,	PUNCT
admet-194	398	7	w.j	w.j	PROPN
admet-194	398	8	.	.	PROPN
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admet-194	398	10	,	,	PUNCT
admet-194	398	11	k.	k.	PROPN
admet-194	398	12	tanemura	tanemura	PROPN
admet-194	398	13	,	,	PUNCT
admet-194	398	14	f.	f.	PROPN
admet-194	398	15	li	li	PROPN
admet-194	398	16	,	,	PUNCT
admet-194	398	17	f.u	f.u	PROPN
admet-194	398	18	.	.	PROPN
admet-194	398	19	hartl	hartl	NOUN
admet-194	398	20	,	,	PUNCT
admet-194	398	21	a.	a.	NOUN
admet-194	398	22	takashima	takashima	PROPN
admet-194	398	23	,	,	PUNCT
admet-194	398	24	g.k	g.k	PROPN
admet-194	398	25	.	.	PROPN
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admet-194	398	27	,	,	PUNCT
admet-194	398	28	p.	p.	NOUN
admet-194	398	29	greengard	greengard	NOUN
admet-194	398	30	,	,	PUNCT
admet-194	398	31	h.	h.	PROPN
admet-194	398	32	xu	xu	PROPN
admet-194	398	33	,	,	PUNCT
admet-194	398	34	proceedings	proceeding	NOUN
admet-194	398	35	of	of	ADP
admet-194	398	36	the	the	DET
admet-194	398	37	national	national	PROPN
admet-194	398	38	academy	academy	PROPN
admet-194	398	39	of	of	ADP
admet-194	398	40	sciences	sciences	PROPN
admet-194	398	41	of	of	ADP
admet-194	398	42	the	the	DET
admet-194	398	43	united	united	PROPN
admet-194	398	44	states	states	PROPN
admet-194	398	45	of	of	ADP
admet-194	398	46	america	america	PROPN
admet-194	398	47	100	100	NUM
admet-194	398	48	(	(	PUNCT
admet-194	398	49	2003	2003	NUM
admet-194	398	50	)	)	PUNCT
admet-194	398	51	721	721	NUM
admet-194	398	52	-	-	SYM
admet-194	398	53	726	726	NUM
admet-194	398	54	.	.	PUNCT
admet-194	399	1	[	[	X
admet-194	399	2	95	95	NUM
admet-194	399	3	]	]	X
admet-194	399	4	c.	c.	PROPN
admet-194	399	5	a.	a.	PROPN
admet-194	399	6	dickey	dickey	PROPN
admet-194	399	7	,	,	PUNCT
admet-194	399	8	j.	j.	PROPN
admet-194	399	9	dunmore	dunmore	PROPN
admet-194	399	10	,	,	PUNCT
admet-194	399	11	b.	b.	PROPN
admet-194	399	12	lu	lu	PROPN
admet-194	399	13	,	,	PUNCT
admet-194	399	14	j.w	j.w	PROPN
admet-194	399	15	.	.	PROPN
admet-194	399	16	wang	wang	PROPN
admet-194	399	17	,	,	PUNCT
admet-194	399	18	w.c	w.c	PROPN
admet-194	399	19	.	.	PROPN
admet-194	399	20	lee	lee	PROPN
admet-194	399	21	,	,	PUNCT
admet-194	399	22	a.	a.	PROPN
admet-194	399	23	kamal	kamal	PROPN
admet-194	399	24	,	,	PUNCT
admet-194	399	25	f.	f.	PROPN
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admet-194	399	27	,	,	PUNCT
admet-194	399	28	c.	c.	PROPN
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admet-194	399	31	m.	m.	PROPN
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admet-194	399	34	l.	l.	PROPN
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admet-194	399	40	(	(	PUNCT
admet-194	399	41	2006	2006	NUM
admet-194	399	42	)	)	PUNCT
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admet-194	399	44	-	-	SYM
admet-194	399	45	755	755	NUM
admet-194	399	46	.	.	PUNCT
admet-194	400	1	[	[	X
admet-194	400	2	96	96	NUM
admet-194	400	3	]	]	X
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admet-194	400	5	m.	m.	PROPN
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admet-194	400	9	of	of	ADP
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admet-194	400	14	(	(	PUNCT
admet-194	400	15	2008	2008	NUM
admet-194	400	16	)	)	PUNCT
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admet-194	400	18	-	-	SYM
admet-194	400	19	168	168	NUM
admet-194	400	20	.	.	PUNCT
admet-194	401	1	[	[	X
admet-194	401	2	97	97	NUM
admet-194	401	3	]	]	PUNCT
admet-194	401	4	k.	k.	PROPN
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admet-194	401	7	,	,	PUNCT
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admet-194	401	20	,	,	PUNCT
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admet-194	401	24	m.	m.	PROPN
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admet-194	401	27	m.j	m.j	PROPN
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admet-194	401	42	,	,	PUNCT
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admet-194	401	44	.	.	PROPN
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admet-194	401	46	,	,	PUNCT
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admet-194	401	55	(	(	PUNCT
admet-194	401	56	2010	2010	NUM
admet-194	401	57	)	)	PUNCT
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admet-194	401	59	-	-	SYM
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admet-194	401	61	.	.	PUNCT
admet-194	402	1	[	[	X
admet-194	402	2	98	98	NUM
admet-194	402	3	]	]	PUNCT
admet-194	402	4	b.	b.	PROPN
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admet-194	402	7	j.	j.	PROPN
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admet-194	402	9	,	,	PUNCT
admet-194	402	10	j.q	j.q	PROPN
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admet-194	402	13	,	,	PUNCT
admet-194	402	14	y.	y.	PROPN
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admet-194	402	17	m.	m.	PROPN
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admet-194	402	19	,	,	PUNCT
admet-194	402	20	j.s	j.s	PROPN
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admet-194	402	23	,	,	PUNCT
admet-194	402	24	a.m.	a.m.	PROPN
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admet-194	402	26	,	,	PUNCT
admet-194	402	27	s.x	s.x	PROPN
admet-194	402	28	.	.	PUNCT
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admet-194	402	30	,	,	PUNCT
admet-194	402	31	c.	c.	PROPN
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admet-194	402	33	,	,	PUNCT
admet-194	402	34	a.b	a.b	PROPN
admet-194	402	35	.	.	PROPN
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admet-194	402	38	,	,	PUNCT
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admet-194	402	40	.	.	PROPN
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admet-194	402	42	,	,	PUNCT
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admet-194	402	44	.	.	PROPN
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admet-194	402	46	,	,	PUNCT
admet-194	402	47	journal	journal	NOUN
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admet-194	402	50	32	32	NUM
admet-194	402	51	(	(	PUNCT
admet-194	402	52	2012	2012	NUM
admet-194	402	53	)	)	PUNCT
admet-194	402	54	3601	3601	NUM
admet-194	402	55	-	-	SYM
admet-194	402	56	3611	3611	NUM
admet-194	402	57	.	.	PUNCT
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admet-194	403	3	]	]	X
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admet-194	403	11	porcel	porcel	PROPN
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admet-194	403	13	m.	m.	PROPN
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admet-194	403	15	,	,	PUNCT
admet-194	403	16	a.k	a.k	PROPN
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admet-194	403	19	,	,	PUNCT
admet-194	403	20	s.m	s.m	PROPN
admet-194	403	21	.	.	PROPN
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admet-194	403	23	,	,	PUNCT
admet-194	403	24	j.q	j.q	PROPN
admet-194	403	25	.	.	PROPN
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admet-194	403	27	,	,	PUNCT
admet-194	403	28	v.	v.	PROPN
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admet-194	403	32	,	,	PUNCT
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admet-194	403	38	(	(	PUNCT
admet-194	403	39	2010	2010	NUM
admet-194	403	40	)	)	PUNCT
admet-194	403	41	1977	1977	NUM
admet-194	403	42	-	-	SYM
admet-194	403	43	1988	1988	NUM
admet-194	403	44	.	.	PUNCT
admet-194	404	1	[	[	X
admet-194	404	2	100	100	NUM
admet-194	404	3	]	]	PUNCT
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admet-194	404	9	,	,	PUNCT
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admet-194	404	14	of	of	ADP
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admet-194	404	26	disease	disease	NOUN
admet-194	404	27	,	,	PUNCT
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admet-194	404	32	)	)	PUNCT
admet-194	404	33	.	.	PUNCT
admet-194	405	1	[	[	X
admet-194	405	2	101	101	NUM
admet-194	405	3	]	]	PUNCT
admet-194	405	4	a.	a.	PROPN
admet-194	405	5	nordberg	nordberg	PROPN
admet-194	405	6	,	,	PUNCT
admet-194	405	7	alzheimer	alzheimer	PROPN
admet-194	405	8	disease	disease	NOUN
admet-194	405	9	and	and	CCONJ
admet-194	405	10	associated	associated	ADJ
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admet-194	405	12	20	20	NUM
admet-194	405	13	(	(	PUNCT
admet-194	405	14	2006	2006	NUM
admet-194	405	15	)	)	PUNCT
admet-194	405	16	s12	s12	PROPN
admet-194	405	17	-	-	PUNCT
admet-194	405	18	s18	s18	PROPN
admet-194	405	19	.	.	PUNCT
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admet-194	406	3	]	]	X
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admet-194	406	18	,	,	PUNCT
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admet-194	406	20	.	.	PROPN
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admet-194	406	39	(	(	PUNCT
admet-194	406	40	2004	2004	NUM
admet-194	406	41	)	)	PUNCT
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admet-194	406	43	-	-	SYM
admet-194	406	44	1193	1193	NUM
admet-194	406	45	.	.	PUNCT
admet-194	407	1	[	[	X
admet-194	407	2	103	103	NUM
admet-194	407	3	]	]	X
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admet-194	407	14	)	)	PUNCT
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admet-194	407	16	.	.	PUNCT
admet-194	408	1	[	[	X
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admet-194	408	20	(	(	PUNCT
admet-194	408	21	2012	2012	NUM
admet-194	408	22	)	)	PUNCT
admet-194	408	23	728983	728983	NUM
admet-194	408	24	.	.	PUNCT
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admet-194	409	3	]	]	X
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admet-194	409	40	(	(	PUNCT
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admet-194	409	42	)	)	PUNCT
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admet-194	409	44	-	-	SYM
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admet-194	409	46	.	.	PUNCT
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admet-194	410	3	]	]	PUNCT
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admet-194	410	17	(	(	PUNCT
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admet-194	410	19	)	)	PUNCT
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admet-194	410	21	-	-	SYM
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admet-194	411	3	]	]	PUNCT
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admet-194	411	33	)	)	PUNCT
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admet-194	411	35	-	-	SYM
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admet-194	411	37	.	.	PUNCT
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admet-194	412	3	]	]	PUNCT
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admet-194	412	7	,	,	PUNCT
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admet-194	412	9	g.	g.	PROPN
admet-194	412	10	parsons	parsons	PROPN
admet-194	412	11	,	,	PUNCT
admet-194	412	12	w.	w.	PROPN
admet-194	412	13	danysz	danysz	PROPN
admet-194	412	14	,	,	PUNCT
admet-194	412	15	behavioural	behavioural	ADJ
admet-194	412	16	pharmacology	pharmacology	NOUN
admet-194	412	17	17	17	NUM
admet-194	412	18	(	(	PUNCT
admet-194	412	19	2006	2006	NUM
admet-194	412	20	)	)	PUNCT
admet-194	412	21	411	411	NUM
admet-194	412	22	-	-	SYM
admet-194	412	23	424	424	NUM
admet-194	412	24	.	.	PUNCT
admet-194	413	1	https://clinicaltrials.gov/ct2/show/nct01492374?term=bms-241027&rank=1	https://clinicaltrials.gov/ct2/show/nct01492374?term=bms-241027&rank=1	PROPN
admet-194	413	2	admet	admet	PROPN
admet-194	413	3	&	&	CCONJ
admet-194	413	4	dmpk	dmpk	PROPN
admet-194	413	5	3(3	3(3	NUM
admet-194	413	6	)	)	PUNCT
admet-194	413	7	(	(	PUNCT
admet-194	413	8	2015	2015	NUM
admet-194	413	9	)	)	PUNCT
admet-194	413	10	216	216	NUM
admet-194	413	11	-	-	SYM
admet-194	413	12	234	234	NUM
admet-194	413	13	chemical	chemical	NOUN
admet-194	413	14	and	and	CCONJ
admet-194	413	15	physical	physical	ADJ
admet-194	413	16	approaches	approach	NOUN
admet-194	413	17	for	for	ADP
admet-194	413	18	the	the	DET
admet-194	413	19	treatment	treatment	NOUN
admet-194	413	20	of	of	ADP
admet-194	413	21	ad	ad	NOUN
admet-194	413	22	doi	doi	NOUN
admet-194	413	23	:	:	PUNCT
admet-194	413	24	10.5599	10.5599	NUM
admet-194	413	25	/	/	SYM
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admet-194	413	27	233	233	NUM
admet-194	413	28	[	[	X
admet-194	413	29	109	109	NUM
admet-194	413	30	]	]	PUNCT
admet-194	413	31	j.	j.	PROPN
admet-194	413	32	j.	j.	PROPN
admet-194	413	33	pei	pei	PROPN
admet-194	413	34	,	,	PUNCT
admet-194	413	35	m.	m.	PROPN
admet-194	413	36	sjogren	sjogren	PROPN
admet-194	413	37	,	,	PUNCT
admet-194	413	38	b.	b.	PROPN
admet-194	413	39	winblad	winblad	PROPN
admet-194	413	40	,	,	PUNCT
admet-194	413	41	current	current	ADJ
admet-194	413	42	opinion	opinion	NOUN
admet-194	413	43	in	in	ADP
admet-194	413	44	psychiatry	psychiatry	NOUN
admet-194	413	45	21	21	NUM
admet-194	413	46	(	(	PUNCT
admet-194	413	47	2008	2008	NUM
admet-194	413	48	)	)	PUNCT
admet-194	413	49	555	555	NUM
admet-194	413	50	-	-	SYM
admet-194	413	51	561	561	NUM
admet-194	413	52	.	.	PUNCT
admet-194	414	1	[	[	X
admet-194	414	2	110	110	NUM
admet-194	414	3	]	]	X
admet-194	414	4	h.m	h.m	PROPN
admet-194	414	5	.	.	PROPN
admet-194	414	6	wu	wu	PROPN
admet-194	414	7	,	,	PUNCT
admet-194	414	8	n.s	n.s	PROPN
admet-194	414	9	.	.	PROPN
admet-194	414	10	tzeng	tzeng	PROPN
admet-194	414	11	,	,	PUNCT
admet-194	414	12	l.	l.	PROPN
admet-194	414	13	qian	qian	PROPN
admet-194	414	14	,	,	PUNCT
admet-194	414	15	s.j	s.j	PROPN
admet-194	414	16	.	.	PROPN
admet-194	414	17	wei	wei	PROPN
admet-194	414	18	,	,	PUNCT
admet-194	414	19	x.	x.	PROPN
admet-194	414	20	hu	hu	PROPN
admet-194	414	21	,	,	PUNCT
admet-194	414	22	s.h	s.h	PROPN
admet-194	414	23	.	.	PROPN
admet-194	414	24	chen	chen	PROPN
admet-194	414	25	,	,	PUNCT
admet-194	414	26	s.m	s.m	PROPN
admet-194	414	27	.	.	PROPN
admet-194	414	28	rawls	rawls	PROPN
admet-194	414	29	,	,	PUNCT
admet-194	414	30	p.	p.	NOUN
admet-194	414	31	flood	flood	PROPN
admet-194	414	32	,	,	PUNCT
admet-194	414	33	j.s	j.s	PROPN
admet-194	414	34	.	.	PROPN
admet-194	414	35	hong	hong	PROPN
admet-194	414	36	,	,	PUNCT
admet-194	414	37	r.b	r.b	PROPN
admet-194	414	38	.	.	PROPN
admet-194	414	39	lu	lu	PROPN
admet-194	414	40	,	,	PUNCT
admet-194	414	41	neuropsychopharmacology	neuropsychopharmacology	X
admet-194	414	42	34	34	NUM
admet-194	414	43	(	(	PUNCT
admet-194	414	44	2009	2009	NUM
admet-194	414	45	)	)	PUNCT
admet-194	414	46	2344	2344	NUM
admet-194	414	47	-	-	SYM
admet-194	414	48	2357	2357	NUM
admet-194	414	49	.	.	PUNCT
admet-194	415	1	[	[	X
admet-194	415	2	111	111	NUM
admet-194	415	3	]	]	PUNCT
admet-194	415	4	g.	g.	PROPN
admet-194	415	5	riedel	riedel	PROPN
admet-194	415	6	,	,	PUNCT
admet-194	415	7	b.	b.	PROPN
admet-194	415	8	platt	platt	PROPN
admet-194	415	9	,	,	PUNCT
admet-194	415	10	j.	j.	PROPN
admet-194	415	11	micheau	micheau	PROPN
admet-194	415	12	,	,	PUNCT
admet-194	415	13	behavioural	behavioural	ADJ
admet-194	415	14	brain	brain	NOUN
admet-194	415	15	research	research	NOUN
admet-194	415	16	140	140	NUM
admet-194	415	17	(	(	PUNCT
admet-194	415	18	2003	2003	NUM
admet-194	415	19	)	)	PUNCT
admet-194	415	20	1	1	NUM
admet-194	415	21	-	-	SYM
admet-194	415	22	47	47	NUM
admet-194	415	23	.	.	PUNCT
admet-194	416	1	[	[	X
admet-194	416	2	112	112	NUM
admet-194	416	3	]	]	PUNCT
admet-194	416	4	a.	a.	PROPN
admet-194	416	5	sanchez	sanchez	PROPN
admet-194	416	6	-	-	PUNCT
admet-194	416	7	perez	perez	PROPN
admet-194	416	8	,	,	PUNCT
admet-194	416	9	m.	m.	NOUN
admet-194	416	10	llansola	llansola	PROPN
admet-194	416	11	,	,	PUNCT
admet-194	416	12	o.	o.	PROPN
admet-194	416	13	cauli	cauli	PROPN
admet-194	416	14	,	,	PUNCT
admet-194	416	15	v.	v.	ADP
admet-194	416	16	felipo	felipo	NOUN
admet-194	416	17	,	,	PUNCT
admet-194	416	18	cerebellum	cerebellum	NOUN
admet-194	416	19	4	4	NUM
admet-194	416	20	(	(	PUNCT
admet-194	416	21	2005	2005	NUM
admet-194	416	22	)	)	PUNCT
admet-194	416	23	162	162	NUM
admet-194	416	24	-	-	SYM
admet-194	416	25	170	170	NUM
admet-194	416	26	.	.	PUNCT
admet-194	417	1	[	[	X
admet-194	417	2	113	113	NUM
admet-194	417	3	]	]	X
admet-194	417	4	u.	u.	NOUN
admet-194	417	5	wojda	wojda	PROPN
admet-194	417	6	,	,	PUNCT
admet-194	417	7	e.	e.	PROPN
admet-194	417	8	salinska	salinska	PROPN
admet-194	417	9	,	,	PUNCT
admet-194	417	10	j.	j.	PROPN
admet-194	417	11	kuznicki	kuznicki	PROPN
admet-194	417	12	,	,	PUNCT
admet-194	417	13	iubmb	iubmb	NOUN
admet-194	417	14	life	life	NOUN
admet-194	417	15	60	60	NUM
admet-194	417	16	(	(	PUNCT
admet-194	417	17	2008	2008	NUM
admet-194	417	18	)	)	PUNCT
admet-194	417	19	575	575	NUM
admet-194	417	20	-	-	SYM
admet-194	417	21	590	590	NUM
admet-194	417	22	.	.	PUNCT
admet-194	418	1	[	[	X
admet-194	418	2	114	114	NUM
admet-194	418	3	]	]	PUNCT
admet-194	418	4	e.	e.	PROPN
admet-194	418	5	bell	bell	PROPN
admet-194	418	6	,	,	PUNCT
admet-194	418	7	g.	g.	PROPN
admet-194	418	8	mathieu	mathieu	PROPN
admet-194	418	9	,	,	PUNCT
admet-194	418	10	e.	e.	PROPN
admet-194	418	11	racine	racine	PROPN
admet-194	418	12	,	,	PUNCT
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admet-194	418	15	72	72	NUM
admet-194	418	16	(	(	PUNCT
admet-194	418	17	2009	2009	NUM
admet-194	418	18	)	)	PUNCT
admet-194	418	19	577	577	NUM
admet-194	418	20	-	-	SYM
admet-194	418	21	586	586	NUM
admet-194	418	22	;	;	PUNCT
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admet-194	418	24	586	586	NUM
admet-194	418	25	.	.	PUNCT
admet-194	419	1	[	[	X
admet-194	419	2	115	115	NUM
admet-194	419	3	]	]	PUNCT
admet-194	419	4	p.	p.	PROPN
admet-194	419	5	e.	e.	PROPN
admet-194	419	6	holtzheimer	holtzheimer	PROPN
admet-194	419	7	,	,	PUNCT
admet-194	419	8	h.	h.	PROPN
admet-194	419	9	s.	s.	PROPN
admet-194	419	10	mayberg	mayberg	PROPN
admet-194	419	11	,	,	PUNCT
admet-194	419	12	annual	annual	ADJ
admet-194	419	13	review	review	NOUN
admet-194	419	14	of	of	ADP
admet-194	419	15	neuroscience	neuroscience	NOUN
admet-194	419	16	34	34	NUM
admet-194	419	17	(	(	PUNCT
admet-194	419	18	2011	2011	NUM
admet-194	419	19	)	)	PUNCT
admet-194	419	20	289	289	NUM
admet-194	419	21	-	-	SYM
admet-194	419	22	307	307	NUM
admet-194	419	23	.	.	PUNCT
admet-194	420	1	[	[	X
admet-194	420	2	116	116	X
admet-194	420	3	]	]	X
admet-194	420	4	s.	s.	PROPN
admet-194	420	5	miocinovic	miocinovic	PROPN
admet-194	420	6	,	,	PUNCT
admet-194	420	7	s.	s.	PROPN
admet-194	420	8	somayajula	somayajula	PROPN
admet-194	420	9	,	,	PUNCT
admet-194	420	10	s.	s.	PROPN
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admet-194	420	12	,	,	PUNCT
admet-194	420	13	j.	j.	PROPN
admet-194	420	14	l.	l.	PROPN
admet-194	420	15	vitek	vitek	PROPN
admet-194	420	16	,	,	PUNCT
admet-194	420	17	journal	journal	NOUN
admet-194	420	18	of	of	ADP
admet-194	420	19	the	the	DET
admet-194	420	20	american	american	PROPN
admet-194	420	21	medical	medical	PROPN
admet-194	420	22	association	association	PROPN
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admet-194	420	24	70	70	NUM
admet-194	420	25	(	(	PUNCT
admet-194	420	26	2013	2013	NUM
admet-194	420	27	)	)	PUNCT
admet-194	420	28	163	163	NUM
admet-194	420	29	-	-	SYM
admet-194	420	30	171	171	NUM
admet-194	420	31	.	.	PUNCT
admet-194	421	1	[	[	X
admet-194	421	2	117	117	NUM
admet-194	421	3	]	]	X
admet-194	421	4	r.j	r.j	PROPN
admet-194	421	5	.	.	PROPN
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admet-194	421	7	,	,	PUNCT
admet-194	421	8	m.a	m.a	PROPN
admet-194	421	9	.	.	PROPN
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admet-194	421	11	,	,	PUNCT
admet-194	421	12	o.a	o.a	PROPN
admet-194	421	13	.	.	PROPN
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admet-194	421	15	,	,	PUNCT
admet-194	421	16	k.h	k.h	PROPN
admet-194	421	17	.	.	PROPN
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admet-194	421	19	,	,	PUNCT
admet-194	421	20	j.a	j.a	PROPN
admet-194	421	21	.	.	PROPN
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admet-194	421	23	,	,	PUNCT
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admet-194	421	27	s.j	s.j	PROPN
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admet-194	421	30	,	,	PUNCT
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admet-194	421	32	and	and	CCONJ
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admet-194	421	34	reviews	review	NOUN
admet-194	421	35	36	36	NUM
admet-194	421	36	(	(	PUNCT
admet-194	421	37	2012	2012	NUM
admet-194	421	38	)	)	PUNCT
admet-194	421	39	1920	1920	NUM
admet-194	421	40	-	-	SYM
admet-194	421	41	1933	1933	NUM
admet-194	421	42	.	.	PUNCT
admet-194	422	1	[	[	X
admet-194	422	2	118	118	NUM
admet-194	422	3	]	]	X
admet-194	422	4	t.e	t.e	PROPN
admet-194	422	5	.	.	PROPN
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admet-194	422	7	,	,	PUNCT
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admet-194	422	9	.	.	PROPN
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admet-194	422	11	,	,	PUNCT
admet-194	422	12	c.	c.	PROPN
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admet-194	422	14	,	,	PUNCT
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admet-194	422	16	kosel	kosel	PROPN
admet-194	422	17	,	,	PUNCT
admet-194	422	18	d.	d.	PROPN
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admet-194	422	20	,	,	PUNCT
admet-194	422	21	n.	n.	PROPN
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admet-194	422	23	,	,	PUNCT
admet-194	423	1	a.y	a.y	PROPN
admet-194	423	2	.	.	PROPN
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admet-194	423	4	,	,	PUNCT
admet-194	423	5	m.	m.	NOUN
admet-194	423	6	kreft	kreft	PROPN
admet-194	423	7	,	,	PUNCT
admet-194	423	8	d.	d.	PROPN
admet-194	423	9	lenartz	lenartz	PROPN
admet-194	423	10	,	,	PUNCT
admet-194	423	11	v.	v.	PROPN
admet-194	423	12	sturm	sturm	PROPN
admet-194	423	13	,	,	PUNCT
admet-194	423	14	neuropsychopharmacology	neuropsychopharmacology	PROPN
admet-194	423	15	33	33	NUM
admet-194	423	16	(	(	PUNCT
admet-194	423	17	2008	2008	NUM
admet-194	423	18	)	)	PUNCT
admet-194	423	19	368	368	NUM
admet-194	423	20	-	-	SYM
admet-194	423	21	377	377	NUM
admet-194	423	22	.	.	PUNCT
admet-194	424	1	[	[	X
admet-194	424	2	119	119	NUM
admet-194	424	3	]	]	X
admet-194	424	4	b.	b.	PROPN
admet-194	424	5	velasques	velasques	PROPN
admet-194	424	6	,	,	PUNCT
admet-194	424	7	c.	c.	PROPN
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admet-194	424	9	,	,	PUNCT
admet-194	424	10	s.	s.	PROPN
admet-194	424	11	teixeira	teixeira	PROPN
admet-194	424	12	,	,	PUNCT
admet-194	424	13	c.	c.	PROPN
admet-194	424	14	cartier	cartier	NOUN
admet-194	424	15	,	,	PUNCT
admet-194	424	16	c.	c.	PROPN
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admet-194	424	18	,	,	PUNCT
admet-194	424	19	f.	f.	PROPN
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admet-194	424	25	,	,	PUNCT
admet-194	424	26	a.	a.	PROPN
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admet-194	424	28	,	,	PUNCT
admet-194	424	29	j.	j.	PROPN
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admet-194	424	31	,	,	PUNCT
admet-194	424	32	a.e	a.e	PROPN
admet-194	424	33	.	.	PROPN
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admet-194	424	35	,	,	PUNCT
admet-194	424	36	e.	e.	PROPN
admet-194	424	37	cheniaux	cheniaux	PROPN
admet-194	424	38	,	,	PUNCT
admet-194	424	39	l.	l.	PROPN
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admet-194	424	41	,	,	PUNCT
admet-194	424	42	m.	m.	NOUN
admet-194	424	43	cagy	cagy	PROPN
admet-194	424	44	,	,	PUNCT
admet-194	424	45	r.	r.	PROPN
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admet-194	424	47	,	,	PUNCT
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admet-194	424	50	,	,	PUNCT
admet-194	424	51	cns	cns	PROPN
admet-194	424	52	&	&	CCONJ
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admet-194	424	54	disorders	disorder	NOUN
admet-194	424	55	-	-	PUNCT
admet-194	424	56	drug	drug	NOUN
admet-194	424	57	targets	target	NOUN
admet-194	424	58	13	13	NUM
admet-194	424	59	(	(	PUNCT
admet-194	424	60	2014	2014	NUM
admet-194	424	61	)	)	PUNCT
admet-194	424	62	961	961	NUM
admet-194	424	63	-	-	PUNCT
admet-194	424	64	971	971	NUM
admet-194	424	65	.	.	PUNCT
admet-194	425	1	[	[	X
admet-194	425	2	120	120	NUM
admet-194	425	3	]	]	PUNCT
admet-194	425	4	r.	r.	PROPN
admet-194	425	5	f.	f.	PROPN
admet-194	425	6	young	young	PROPN
admet-194	425	7	,	,	PUNCT
admet-194	425	8	t.	t.	PROPN
admet-194	425	9	brechner	brechner	NOUN
admet-194	425	10	,	,	PUNCT
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admet-194	425	12	57	57	NUM
admet-194	425	13	(	(	PUNCT
admet-194	425	14	1986	1986	NUM
admet-194	425	15	)	)	PUNCT
admet-194	425	16	1266	1266	NUM
admet-194	425	17	-	-	SYM
admet-194	425	18	1272	1272	NUM
admet-194	425	19	.	.	PUNCT
admet-194	426	1	[	[	X
admet-194	426	2	121	121	NUM
admet-194	426	3	]	]	PUNCT
admet-194	426	4	b.	b.	PROPN
admet-194	426	5	jenkins	jenkins	PROPN
admet-194	426	6	,	,	PUNCT
admet-194	426	7	s.	s.	PROPN
admet-194	426	8	j.	j.	PROPN
admet-194	426	9	tepper	tepper	PROPN
admet-194	426	10	,	,	PUNCT
admet-194	426	11	headache	headache	PROPN
admet-194	426	12	51	51	NUM
admet-194	426	13	(	(	PUNCT
admet-194	426	14	2011	2011	NUM
admet-194	426	15	)	)	PUNCT
admet-194	426	16	1408	1408	NUM
admet-194	426	17	-	-	SYM
admet-194	426	18	1418	1418	NUM
admet-194	426	19	.	.	PUNCT
admet-194	427	1	[	[	X
admet-194	427	2	122	122	NUM
admet-194	427	3	]	]	X
admet-194	427	4	a.w	a.w	PROPN
admet-194	427	5	.	.	PROPN
admet-194	427	6	laxton	laxton	PROPN
admet-194	427	7	,	,	PUNCT
admet-194	427	8	d.f	d.f	PROPN
admet-194	427	9	.	.	PROPN
admet-194	427	10	tang	tang	PROPN
admet-194	427	11	-	-	PUNCT
admet-194	427	12	wai	wai	PROPN
admet-194	427	13	,	,	PUNCT
admet-194	427	14	m.p	m.p	PROPN
admet-194	427	15	.	.	PROPN
admet-194	427	16	mcandrews	mcandrews	PROPN
admet-194	427	17	,	,	PUNCT
admet-194	427	18	d.	d.	PROPN
admet-194	427	19	zumsteg	zumsteg	PROPN
admet-194	427	20	,	,	PUNCT
admet-194	427	21	r.	r.	PROPN
admet-194	427	22	wennberg	wennberg	PROPN
admet-194	427	23	,	,	PUNCT
admet-194	427	24	r.	r.	PROPN
admet-194	427	25	keren	keren	PROPN
admet-194	427	26	,	,	PUNCT
admet-194	427	27	j.	j.	PROPN
admet-194	427	28	wherrett	wherrett	PROPN
admet-194	427	29	,	,	PUNCT
admet-194	427	30	g.	g.	PROPN
admet-194	427	31	naglie	naglie	PROPN
admet-194	427	32	,	,	PUNCT
admet-194	427	33	c.	c.	PROPN
admet-194	427	34	hamani	hamani	PROPN
admet-194	427	35	,	,	PUNCT
admet-194	427	36	g.s	g.s	PROPN
admet-194	427	37	.	.	PROPN
admet-194	427	38	smith	smith	PROPN
admet-194	427	39	,	,	PUNCT
admet-194	427	40	a.m.	a.m.	PROPN
admet-194	427	41	lozano	lozano	PROPN
admet-194	427	42	,	,	PUNCT
admet-194	427	43	annals	annal	NOUN
admet-194	427	44	of	of	ADP
admet-194	427	45	neurology	neurology	NOUN
admet-194	427	46	68	68	NUM
admet-194	427	47	(	(	PUNCT
admet-194	427	48	2010	2010	NUM
admet-194	427	49	)	)	PUNCT
admet-194	427	50	521	521	NUM
admet-194	427	51	-	-	SYM
admet-194	427	52	534	534	NUM
admet-194	427	53	.	.	PUNCT
admet-194	428	1	[	[	X
admet-194	428	2	123	123	NUM
admet-194	428	3	]	]	X
admet-194	428	4	d.	d.	PROPN
admet-194	428	5	fontaine	fontaine	PROPN
admet-194	428	6	,	,	PUNCT
admet-194	428	7	a.	a.	NOUN
admet-194	428	8	deudon	deudon	PROPN
admet-194	428	9	,	,	PUNCT
admet-194	428	10	j.j	j.j	PROPN
admet-194	428	11	.	.	PROPN
admet-194	428	12	lemaire	lemaire	PROPN
admet-194	428	13	,	,	PUNCT
admet-194	428	14	m.	m.	NOUN
admet-194	428	15	razzouk	razzouk	PROPN
admet-194	428	16	,	,	PUNCT
admet-194	428	17	p.	p.	PROPN
admet-194	428	18	viau	viau	PROPN
admet-194	428	19	,	,	PUNCT
admet-194	428	20	j.	j.	PROPN
admet-194	428	21	darcourt	darcourt	PROPN
admet-194	428	22	,	,	PUNCT
admet-194	428	23	p.	p.	PROPN
admet-194	428	24	robert	robert	PROPN
admet-194	428	25	,	,	PUNCT
admet-194	428	26	journal	journal	PROPN
admet-194	428	27	of	of	ADP
admet-194	428	28	alzheimer	alzheimer	PROPN
admet-194	428	29	’s	’s	PART
admet-194	428	30	disease	disease	NOUN
admet-194	428	31	34	34	NUM
admet-194	428	32	(	(	PUNCT
admet-194	428	33	2013	2013	NUM
admet-194	428	34	)	)	PUNCT
admet-194	428	35	315	315	NUM
admet-194	428	36	-	-	SYM
admet-194	428	37	323	323	NUM
admet-194	428	38	.	.	PUNCT
admet-194	429	1	[	[	X
admet-194	429	2	124	124	NUM
admet-194	429	3	]	]	X
admet-194	429	4	h.j	h.j	PROPN
admet-194	429	5	.	.	PROPN
admet-194	429	6	freund	freund	PROPN
admet-194	429	7	,	,	PUNCT
admet-194	429	8	j.	j.	PROPN
admet-194	429	9	kuhn	kuhn	PROPN
admet-194	429	10	,	,	PUNCT
admet-194	429	11	d.	d.	PROPN
admet-194	429	12	lenartz	lenartz	PROPN
admet-194	429	13	,	,	PUNCT
admet-194	429	14	j.k	j.k	PROPN
admet-194	429	15	.	.	PROPN
admet-194	429	16	mai	mai	PROPN
admet-194	429	17	,	,	PUNCT
admet-194	429	18	t.	t.	PROPN
admet-194	429	19	schnell	schnell	PROPN
admet-194	429	20	,	,	PUNCT
admet-194	429	21	j.	j.	PROPN
admet-194	429	22	klosterkoetter	klosterkoetter	PROPN
admet-194	429	23	,	,	PUNCT
admet-194	429	24	v.	v.	PROPN
admet-194	429	25	sturm	sturm	PROPN
admet-194	429	26	,	,	PUNCT
admet-194	429	27	archives	archive	NOUN
admet-194	429	28	of	of	ADP
admet-194	429	29	neurology	neurology	NOUN
admet-194	429	30	66	66	NUM
admet-194	429	31	(	(	PUNCT
admet-194	429	32	2009	2009	NUM
admet-194	429	33	)	)	PUNCT
admet-194	429	34	781	781	NUM
admet-194	429	35	-	-	SYM
admet-194	429	36	785	785	NUM
admet-194	429	37	.	.	PUNCT
admet-194	430	1	[	[	X
admet-194	430	2	125	125	NUM
admet-194	430	3	]	]	PUNCT
admet-194	430	4	j.	j.	PROPN
admet-194	430	5	kuhn	kuhn	PROPN
admet-194	430	6	,	,	PUNCT
admet-194	430	7	k.	k.	PROPN
admet-194	430	8	hardenacke	hardenacke	PROPN
admet-194	430	9	,	,	PUNCT
admet-194	430	10	d.	d.	PROPN
admet-194	430	11	lenartz	lenartz	PROPN
admet-194	430	12	,	,	PUNCT
admet-194	430	13	t.	t.	NOUN
admet-194	430	14	gruendler	gruendler	NOUN
admet-194	430	15	,	,	PUNCT
admet-194	430	16	m.	m.	NOUN
admet-194	430	17	ullsperger	ullsperger	NOUN
admet-194	430	18	,	,	PUNCT
admet-194	430	19	c.	c.	PROPN
admet-194	430	20	bartsch	bartsch	PROPN
admet-194	430	21	,	,	PUNCT
admet-194	430	22	j.k	j.k	PROPN
admet-194	430	23	.	.	PROPN
admet-194	430	24	mai	mai	PROPN
admet-194	430	25	,	,	PUNCT
admet-194	430	26	k.	k.	PROPN
admet-194	430	27	zilles	zilles	PROPN
admet-194	430	28	,	,	PUNCT
admet-194	430	29	a.	a.	PROPN
admet-194	430	30	bauer	bauer	PROPN
admet-194	430	31	,	,	PUNCT
admet-194	430	32	a.	a.	NOUN
admet-194	430	33	matusch	matusch	PROPN
admet-194	430	34	,	,	PUNCT
admet-194	430	35	r.j	r.j	PROPN
admet-194	430	36	.	.	PROPN
admet-194	430	37	schulz	schulz	PROPN
admet-194	430	38	,	,	PUNCT
admet-194	430	39	m.	m.	PROPN
admet-194	430	40	noreik	noreik	PROPN
admet-194	430	41	,	,	PUNCT
admet-194	430	42	c.p	c.p	PROPN
admet-194	430	43	.	.	PROPN
admet-194	430	44	bührle	bührle	PROPN
admet-194	430	45	,	,	PUNCT
admet-194	430	46	d.	d.	PROPN
admet-194	430	47	maintz	maintz	PROPN
admet-194	430	48	,	,	PUNCT
admet-194	430	49	c.	c.	PROPN
admet-194	430	50	woopen	woopen	PROPN
admet-194	430	51	,	,	PUNCT
admet-194	430	52	p.	p.	PROPN
admet-194	430	53	häussermann	häussermann	PROPN
admet-194	430	54	,	,	PUNCT
admet-194	430	55	m.	m.	PROPN
admet-194	430	56	hellmich	hellmich	PROPN
admet-194	430	57	,	,	PUNCT
admet-194	430	58	j.	j.	PROPN
admet-194	430	59	klosterkötter	klosterkötter	PROPN
admet-194	430	60	,	,	PUNCT
admet-194	430	61	j.	j.	PROPN
admet-194	430	62	wiltfang	wiltfang	PROPN
admet-194	430	63	,	,	PUNCT
admet-194	430	64	m.	m.	PROPN
admet-194	430	65	maarouf	maarouf	PROPN
admet-194	430	66	,	,	PUNCT
admet-194	430	67	h.j	h.j	PROPN
admet-194	430	68	.	.	PROPN
admet-194	430	69	freund	freund	PROPN
admet-194	430	70	,	,	PUNCT
admet-194	430	71	v.	v.	PROPN
admet-194	430	72	sturm	sturm	PROPN
admet-194	430	73	,	,	PUNCT
admet-194	430	74	molecular	molecular	ADJ
admet-194	430	75	psychiatry	psychiatry	NOUN
admet-194	430	76	20	20	NUM
admet-194	430	77	(	(	PUNCT
admet-194	430	78	2015	2015	NUM
admet-194	430	79	)	)	PUNCT
admet-194	430	80	353360	353360	NUM
admet-194	430	81	.	.	PUNCT
admet-194	431	1	[	[	X
admet-194	431	2	126	126	NUM
admet-194	431	3	]	]	PUNCT
admet-194	431	4	j.	j.	PROPN
admet-194	431	5	p.	p.	PROPN
admet-194	431	6	aggleton	aggleton	PROPN
admet-194	431	7	,	,	PUNCT
admet-194	431	8	r.	r.	PROPN
admet-194	431	9	desimone	desimone	PROPN
admet-194	431	10	,	,	PUNCT
admet-194	431	11	m.	m.	NOUN
admet-194	431	12	mishkin	mishkin	PROPN
admet-194	431	13	,	,	PUNCT
admet-194	431	14	journal	journal	NOUN
admet-194	431	15	of	of	ADP
admet-194	431	16	comparative	comparative	ADJ
admet-194	431	17	neurology	neurology	NOUN
admet-194	431	18	243	243	NUM
admet-194	431	19	(	(	PUNCT
admet-194	431	20	1986	1986	NUM
admet-194	431	21	)	)	PUNCT
admet-194	431	22	409	409	NUM
admet-194	431	23	-	-	SYM
admet-194	431	24	421	421	NUM
admet-194	431	25	.	.	PUNCT
admet-194	432	1	[	[	X
admet-194	432	2	127	127	NUM
admet-194	432	3	]	]	X
admet-194	432	4	n.	n.	PROPN
admet-194	432	5	neave	neave	PROPN
admet-194	432	6	,	,	PUNCT
admet-194	432	7	s.	s.	PROPN
admet-194	432	8	lloyd	lloyd	PROPN
admet-194	432	9	,	,	PUNCT
admet-194	432	10	a.	a.	PROPN
admet-194	432	11	sahgal	sahgal	PROPN
admet-194	432	12	,	,	PUNCT
admet-194	432	13	j.	j.	PROPN
admet-194	432	14	p.	p.	PROPN
admet-194	432	15	aggleton	aggleton	PROPN
admet-194	432	16	,	,	PUNCT
admet-194	432	17	behavioural	behavioural	ADJ
admet-194	432	18	brain	brain	NOUN
admet-194	432	19	research	research	NOUN
admet-194	432	20	65	65	NUM
admet-194	432	21	(	(	PUNCT
admet-194	432	22	1994	1994	NUM
admet-194	432	23	)	)	PUNCT
admet-194	432	24	89	89	NUM
admet-194	432	25	-	-	SYM
admet-194	432	26	101	101	NUM
admet-194	432	27	.	.	PUNCT
admet-194	433	1	[	[	X
admet-194	433	2	128	128	NUM
admet-194	433	3	]	]	X
admet-194	433	4	c.	c.	PROPN
admet-194	433	5	hamani	hamani	PROPN
admet-194	433	6	,	,	PUNCT
admet-194	433	7	m.p	m.p	PROPN
admet-194	433	8	.	.	PROPN
admet-194	433	9	mcandrews	mcandrews	PROPN
admet-194	433	10	,	,	PUNCT
admet-194	433	11	m.	m.	PROPN
admet-194	433	12	cohn	cohn	PROPN
admet-194	433	13	,	,	PUNCT
admet-194	433	14	m.	m.	NOUN
admet-194	433	15	oh	oh	INTJ
admet-194	433	16	,	,	PUNCT
admet-194	433	17	d.	d.	PROPN
admet-194	433	18	zumsteg	zumsteg	PROPN
admet-194	433	19	,	,	PUNCT
admet-194	433	20	c.m	c.m	PROPN
admet-194	433	21	.	.	PROPN
admet-194	433	22	shapiro	shapiro	PROPN
admet-194	433	23	,	,	PUNCT
admet-194	433	24	r.a	r.a	PROPN
admet-194	433	25	.	.	PROPN
admet-194	433	26	wennberg	wennberg	PROPN
admet-194	433	27	,	,	PUNCT
admet-194	433	28	a.m.	a.m.	PROPN
admet-194	434	1	lozano	lozano	PROPN
admet-194	434	2	,	,	PUNCT
admet-194	434	3	annals	annal	NOUN
admet-194	434	4	of	of	ADP
admet-194	434	5	neurology	neurology	NOUN
admet-194	434	6	63	63	NUM
admet-194	434	7	(	(	PUNCT
admet-194	434	8	2008	2008	NUM
admet-194	434	9	)	)	PUNCT
admet-194	434	10	119	119	NUM
admet-194	434	11	-	-	SYM
admet-194	434	12	123	123	NUM
admet-194	434	13	.	.	PUNCT
admet-194	435	1	[	[	X
admet-194	435	2	129	129	NUM
admet-194	435	3	]	]	PUNCT
admet-194	435	4	advance	advance	NOUN
admet-194	435	5	dbs	dbs	PROPN
admet-194	435	6	-	-	PROPN
admet-194	435	7	f	f	PROPN
admet-194	435	8	in	in	ADP
admet-194	435	9	patients	patient	NOUN
admet-194	435	10	with	with	ADP
admet-194	435	11	mild	mild	ADJ
admet-194	435	12	probable	probable	ADJ
admet-194	435	13	alzheimer	alzheimer	NOUN
admet-194	435	14	's	's	PART
admet-194	435	15	disease	disease	NOUN
admet-194	435	16	,	,	PUNCT
admet-194	435	17	https://clinicaltrials.gov/ct2/show/nct01608061?term=fornix+dbs&rank=4	https://clinicaltrials.gov/ct2/show/nct01608061?term=fornix+dbs&rank=4	PROPN
admet-194	435	18	(	(	PUNCT
admet-194	435	19	march	march	PROPN
admet-194	435	20	2015	2015	NUM
admet-194	435	21	)	)	PUNCT
admet-194	435	22	.	.	PUNCT
admet-194	436	1	[	[	X
admet-194	436	2	130	130	NUM
admet-194	436	3	]	]	PUNCT
admet-194	436	4	f.	f.	PROPN
admet-194	436	5	amenta	amenta	PROPN
admet-194	436	6	,	,	PUNCT
admet-194	436	7	e.	e.	PROPN
admet-194	436	8	bronzetti	bronzetti	PROPN
admet-194	436	9	,	,	PUNCT
admet-194	436	10	m.g	m.g	PROPN
admet-194	436	11	.	.	PROPN
admet-194	436	12	caporali	caporali	PROPN
admet-194	436	13	,	,	PUNCT
admet-194	436	14	e.	e.	PROPN
admet-194	436	15	ciriaco	ciriaco	PROPN
admet-194	436	16	,	,	PUNCT
admet-194	436	17	g.p	g.p	PROPN
admet-194	436	18	.	.	PROPN
admet-194	436	19	germana	germana	PROPN
admet-194	436	20	,	,	PUNCT
admet-194	436	21	t.	t.	PROPN
admet-194	436	22	niglio	niglio	NOUN
admet-194	436	23	,	,	PUNCT
admet-194	436	24	a.	a.	PROPN
admet-194	436	25	ricci	ricci	PROPN
admet-194	436	26	,	,	PUNCT
admet-194	436	27	a.s	a.s	PROPN
admet-194	436	28	.	.	PROPN
admet-194	436	29	de	de	PROPN
admet-194	436	30	carolis	carolis	PROPN
admet-194	436	31	,	,	PUNCT
admet-194	436	32	archives	archive	NOUN
admet-194	436	33	of	of	ADP
admet-194	436	34	gerontology	gerontology	NOUN
admet-194	436	35	and	and	CCONJ
admet-194	436	36	geriatrics	geriatric	NOUN
admet-194	436	37	12	12	NUM
admet-194	436	38	(	(	PUNCT
admet-194	436	39	1991	1991	NUM
admet-194	436	40	)	)	PUNCT
admet-194	436	41	49	49	NUM
admet-194	436	42	-	-	SYM
admet-194	436	43	58	58	NUM
admet-194	436	44	.	.	PUNCT
admet-194	437	1	[	[	X
admet-194	437	2	131	131	NUM
admet-194	437	3	]	]	X
admet-194	437	4	i.	i.	PROPN
admet-194	437	5	panocka	panocka	PROPN
admet-194	437	6	,	,	PUNCT
admet-194	437	7	s.	s.	PROPN
admet-194	437	8	sagratella	sagratella	PROPN
admet-194	437	9	,	,	PUNCT
admet-194	437	10	a.	a.	NOUN
admet-194	437	11	scotti	scotti	PROPN
admet-194	437	12	de	de	X
admet-194	437	13	carolis	carolis	PROPN
admet-194	437	14	,	,	PUNCT
admet-194	437	15	y.	y.	PROPN
admet-194	437	16	c.	c.	PROPN
admet-194	437	17	zeng	zeng	PROPN
admet-194	437	18	,	,	PUNCT
admet-194	437	19	f.	f.	PROPN
admet-194	437	20	amenta	amenta	PROPN
admet-194	437	21	,	,	PUNCT
admet-194	437	22	neuroscience	neuroscience	NOUN
admet-194	437	23	letter	letter	NOUN
admet-194	437	24	190	190	NUM
admet-194	437	25	(	(	PUNCT
admet-194	437	26	1995	1995	NUM
admet-194	437	27	)	)	PUNCT
admet-194	437	28	207	207	NUM
admet-194	437	29	-	-	SYM
admet-194	437	30	211	211	NUM
admet-194	437	31	.	.	PUNCT
admet-194	438	1	[	[	X
admet-194	438	2	132	132	NUM
admet-194	438	3	]	]	PUNCT
admet-194	438	4	m.	m.	NOUN
admet-194	438	5	sabbatini	sabbatini	PROPN
admet-194	438	6	et	et	PROPN
admet-194	438	7	al	al	PROPN
admet-194	438	8	.	.	PROPN
admet-194	438	9	,	,	PUNCT
admet-194	438	10	mechanisms	mechanism	NOUN
admet-194	438	11	of	of	ADP
admet-194	438	12	ageing	ageing	NOUN
admet-194	438	13	and	and	CCONJ
admet-194	438	14	development	development	NOUN
admet-194	438	15	107	107	NUM
admet-194	438	16	(	(	PUNCT
admet-194	438	17	1999	1999	NUM
admet-194	438	18	)	)	PUNCT
admet-194	438	19	147	147	NUM
admet-194	438	20	-	-	SYM
admet-194	438	21	157	157	NUM
admet-194	438	22	.	.	PUNCT
admet-194	439	1	[	[	X
admet-194	439	2	133	133	NUM
admet-194	439	3	]	]	X
admet-194	439	4	v.	v.	ADP
admet-194	439	5	parikh	parikh	PROPN
admet-194	439	6	,	,	PUNCT
admet-194	439	7	m.	m.	NOUN
admet-194	439	8	sarter	sarter	PROPN
admet-194	439	9	,	,	PUNCT
admet-194	439	10	molecular	molecular	ADJ
admet-194	439	11	and	and	CCONJ
admet-194	439	12	biophysical	biophysical	ADJ
admet-194	439	13	mechanisms	mechanism	NOUN
admet-194	439	14	of	of	ADP
admet-194	439	15	arousal	arousal	NOUN
admet-194	439	16	,	,	PUNCT
admet-194	439	17	alertness	alertness	NOUN
admet-194	439	18	,	,	PUNCT
admet-194	439	19	and	and	CCONJ
admet-194	439	20	attention	attention	NOUN
admet-194	439	21	1129	1129	NUM
admet-194	439	22	(	(	PUNCT
admet-194	439	23	2008	2008	NUM
admet-194	439	24	)	)	PUNCT
admet-194	439	25	225	225	NUM
admet-194	439	26	-	-	SYM
admet-194	439	27	235	235	NUM
admet-194	439	28	.	.	PUNCT
admet-194	440	1	[	[	X
admet-194	440	2	134	134	NUM
admet-194	440	3	]	]	PUNCT
admet-194	440	4	b.	b.	PROPN
admet-194	440	5	j.	j.	PROPN
admet-194	440	6	everitt	everitt	PROPN
admet-194	440	7	,	,	PUNCT
admet-194	440	8	t.	t.	PROPN
admet-194	440	9	w.	w.	PROPN
admet-194	440	10	robbins	robbins	PROPN
admet-194	440	11	,	,	PUNCT
admet-194	440	12	annual	annual	ADJ
admet-194	440	13	review	review	NOUN
admet-194	440	14	of	of	ADP
admet-194	440	15	psychology	psychology	NOUN
admet-194	440	16	48	48	NUM
admet-194	440	17	(	(	PUNCT
admet-194	440	18	1997	1997	NUM
admet-194	440	19	)	)	PUNCT
admet-194	440	20	649	649	NUM
admet-194	440	21	-	-	SYM
admet-194	440	22	684	684	NUM
admet-194	440	23	.	.	PUNCT
admet-194	441	1	[	[	X
admet-194	441	2	135	135	NUM
admet-194	441	3	]	]	PUNCT
admet-194	441	4	m.	m.	NOUN
admet-194	441	5	sarter	sarter	PROPN
admet-194	441	6	,	,	PUNCT
admet-194	441	7	j.	j.	PROPN
admet-194	441	8	p.	p.	PROPN
admet-194	441	9	bruno	bruno	PROPN
admet-194	441	10	,	,	PUNCT
admet-194	441	11	brain	brain	NOUN
admet-194	441	12	research	research	NOUN
admet-194	441	13	reviews	review	NOUN
admet-194	441	14	23	23	NUM
admet-194	441	15	(	(	PUNCT
admet-194	441	16	1997	1997	NUM
admet-194	441	17	)	)	PUNCT
admet-194	441	18	28	28	NUM
admet-194	441	19	-	-	SYM
admet-194	441	20	46	46	NUM
admet-194	441	21	.	.	PUNCT
admet-194	442	1	[	[	X
admet-194	442	2	136	136	NUM
admet-194	442	3	]	]	PUNCT
admet-194	442	4	l.	l.	PROPN
admet-194	442	5	zaborszky	zaborszky	PROPN
admet-194	442	6	,	,	PUNCT
admet-194	442	7	k.	k.	PROPN
admet-194	442	8	pang	pang	PROPN
admet-194	442	9	,	,	PUNCT
admet-194	442	10	j.	j.	PROPN
admet-194	442	11	somogyi	somogyi	PROPN
admet-194	442	12	,	,	PUNCT
admet-194	442	13	z.	z.	PROPN
admet-194	442	14	nadasdy	nadasdy	PROPN
admet-194	442	15	,	,	PUNCT
admet-194	442	16	i.	i.	PROPN
admet-194	442	17	kallo	kallo	PROPN
admet-194	442	18	,	,	PUNCT
admet-194	442	19	advancing	advance	VERB
admet-194	442	20	from	from	ADP
admet-194	442	21	the	the	DET
admet-194	442	22	ventral	ventral	ADJ
admet-194	442	23	striatum	striatum	NOUN
admet-194	442	24	to	to	ADP
admet-194	442	25	the	the	DET
admet-194	442	26	extended	extended	ADJ
admet-194	442	27	amygdala	amygdala	NOUN
admet-194	442	28	877	877	NUM
admet-194	442	29	(	(	PUNCT
admet-194	442	30	1999	1999	NUM
admet-194	442	31	)	)	PUNCT
admet-194	442	32	339	339	NUM
admet-194	442	33	-	-	SYM
admet-194	442	34	367	367	NUM
admet-194	442	35	.	.	PUNCT
admet-194	443	1	https://clinicaltrials.gov/ct2/show/nct01608061?term=fornix+dbs&rank=4	https://clinicaltrials.gov/ct2/show/nct01608061?term=fornix+dbs&rank=4	PROPN
admet-194	443	2	jing	jing	PROPN
admet-194	443	3	li	li	PROPN
admet-194	443	4	et	et	PROPN
admet-194	443	5	al	al	PROPN
admet-194	443	6	.	.	PROPN
admet-194	443	7	admet	admet	PROPN
admet-194	443	8	&	&	CCONJ
admet-194	443	9	dmpk	dmpk	PROPN
admet-194	443	10	3(3	3(3	NUM
admet-194	443	11	)	)	PUNCT
admet-194	443	12	(	(	PUNCT
admet-194	443	13	2015	2015	NUM
admet-194	443	14	)	)	PUNCT
admet-194	443	15	216	216	NUM
admet-194	443	16	-	-	SYM
admet-194	443	17	234	234	NUM
admet-194	443	18	234	234	NUM
admet-194	443	19	[	[	X
admet-194	443	20	137	137	NUM
admet-194	443	21	]	]	PUNCT
admet-194	443	22	a.	a.	NOUN
admet-194	443	23	montero	montero	PROPN
admet-194	443	24	-	-	PUNCT
admet-194	443	25	pastor	pastor	NOUN
admet-194	443	26	,	,	PUNCT
admet-194	443	27	a.	a.	NOUN
admet-194	443	28	vale	vale	PROPN
admet-194	443	29	-	-	PUNCT
admet-194	443	30	martinez	martinez	PROPN
admet-194	443	31	,	,	PUNCT
admet-194	443	32	g.	g.	PROPN
admet-194	443	33	g.	g.	PROPN
admet-194	443	34	guillazo	guillazo	NOUN
admet-194	443	35	-	-	PUNCT
admet-194	443	36	blanch	blanch	NOUN
admet-194	443	37	,	,	PUNCT
admet-194	443	38	m.	m.	NOUN
admet-194	443	39	marti	marti	PROPN
admet-194	443	40	-	-	PUNCT
admet-194	443	41	nicolovius	nicolovius	PROPN
admet-194	443	42	,	,	PUNCT
admet-194	443	43	behavioural	behavioural	ADJ
admet-194	443	44	brain	brain	NOUN
admet-194	443	45	research	research	NOUN
admet-194	443	46	154	154	NUM
admet-194	443	47	(	(	PUNCT
admet-194	443	48	2004	2004	NUM
admet-194	443	49	)	)	PUNCT
admet-194	443	50	41	41	NUM
admet-194	443	51	-	-	SYM
admet-194	443	52	54	54	NUM
admet-194	443	53	.	.	PUNCT
admet-194	444	1	[	[	X
admet-194	444	2	138	138	NUM
admet-194	444	3	]	]	X
admet-194	444	4	s.	s.	PROPN
admet-194	444	5	hescham	hescham	PROPN
admet-194	444	6	,	,	PUNCT
admet-194	444	7	l.w	l.w	PROPN
admet-194	444	8	.	.	PROPN
admet-194	444	9	lim	lim	PROPN
admet-194	444	10	,	,	PUNCT
admet-194	444	11	a.	a.	NOUN
admet-194	444	12	jahanshahi	jahanshahi	PROPN
admet-194	444	13	,	,	PUNCT
admet-194	444	14	h.w	h.w	PROPN
admet-194	444	15	.	.	PROPN
admet-194	444	16	steinbusch	steinbusch	PROPN
admet-194	444	17	,	,	PUNCT
admet-194	444	18	j.	j.	PROPN
admet-194	444	19	prickaerts	prickaerts	PROPN
admet-194	444	20	,	,	PUNCT
admet-194	444	21	a	a	DET
admet-194	444	22	blokland	blokland	NOUN
admet-194	444	23	,	,	PUNCT
admet-194	444	24	y.	y.	PROPN
admet-194	444	25	temel	temel	PROPN
admet-194	444	26	,	,	PUNCT
admet-194	444	27	brain	brain	NOUN
admet-194	444	28	stimulation	stimulation	NOUN
admet-194	444	29	6	6	NUM
admet-194	444	30	(	(	PUNCT
admet-194	444	31	2013	2013	NUM
admet-194	444	32	)	)	PUNCT
admet-194	444	33	72	72	NUM
admet-194	444	34	-	-	SYM
admet-194	444	35	77	77	NUM
admet-194	444	36	.	.	PUNCT
admet-194	445	1	[	[	X
admet-194	445	2	139	139	NUM
admet-194	445	3	]	]	PUNCT
admet-194	445	4	a.	a.	NOUN
admet-194	445	5	montero	montero	PROPN
admet-194	445	6	-	-	PUNCT
admet-194	445	7	pastor	pastor	NOUN
admet-194	445	8	,	,	PUNCT
admet-194	445	9	a.	a.	NOUN
admet-194	445	10	vale	vale	PROPN
admet-194	445	11	-	-	PUNCT
admet-194	445	12	martinez	martinez	PROPN
admet-194	445	13	,	,	PUNCT
admet-194	445	14	g.	g.	PROPN
admet-194	445	15	guillazo	guillazo	NOUN
admet-194	445	16	-	-	PUNCT
admet-194	445	17	blanch	blanch	NOUN
admet-194	445	18	,	,	PUNCT
admet-194	445	19	m.	m.	NOUN
admet-194	445	20	marti	marti	PROPN
admet-194	445	21	-	-	PUNCT
admet-194	445	22	nicolovius	nicolovius	PROPN
admet-194	445	23	,	,	PUNCT
admet-194	445	24	behavioural	behavioural	ADJ
admet-194	445	25	brain	brain	NOUN
admet-194	445	26	research	research	NOUN
admet-194	445	27	154	154	NUM
admet-194	445	28	(	(	PUNCT
admet-194	445	29	2004	2004	NUM
admet-194	445	30	)	)	PUNCT
admet-194	445	31	41	41	NUM
admet-194	445	32	-	-	SYM
admet-194	445	33	54	54	NUM
admet-194	445	34	.	.	PUNCT
admet-194	446	1	[	[	X
admet-194	446	2	140	140	NUM
admet-194	446	3	]	]	X
admet-194	446	4	n.	n.	NOUN
admet-194	446	5	boix	boix	PROPN
admet-194	446	6	-	-	PUNCT
admet-194	446	7	trelis	trelis	PROPN
admet-194	446	8	,	,	PUNCT
admet-194	446	9	a.	a.	NOUN
admet-194	446	10	vale	vale	PROPN
admet-194	446	11	-	-	PUNCT
admet-194	446	12	martinez	martinez	PROPN
admet-194	446	13	,	,	PUNCT
admet-194	446	14	g.	g.	PROPN
admet-194	446	15	guillazo	guillazo	NOUN
admet-194	446	16	-	-	PUNCT
admet-194	446	17	blanch	blanch	NOUN
admet-194	446	18	,	,	PUNCT
admet-194	446	19	d.	d.	PROPN
admet-194	446	20	costa	costa	PROPN
admet-194	446	21	-	-	PUNCT
admet-194	446	22	miserachs	miserach	NOUN
admet-194	446	23	,	,	PUNCT
admet-194	446	24	m.	m.	NOUN
admet-194	446	25	marti	marti	PROPN
admet-194	446	26	-	-	PUNCT
admet-194	446	27	nicolovius	nicolovius	PROPN
admet-194	446	28	,	,	PUNCT
admet-194	446	29	learn	learn	VERB
admet-194	446	30	memory	memory	NOUN
admet-194	446	31	13	13	NUM
admet-194	446	32	(	(	PUNCT
admet-194	446	33	2006	2006	NUM
admet-194	446	34	)	)	PUNCT
admet-194	446	35	783	783	NUM
admet-194	446	36	-	-	SYM
admet-194	446	37	793	793	NUM
admet-194	446	38	.	.	PUNCT
admet-194	447	1	[	[	X
admet-194	447	2	141	141	NUM
admet-194	447	3	]	]	X
admet-194	447	4	h.	h.	PROPN
admet-194	447	5	hotta	hotta	PROPN
admet-194	447	6	,	,	PUNCT
admet-194	447	7	f.	f.	PROPN
admet-194	447	8	kagitani	kagitani	PROPN
admet-194	447	9	,	,	PUNCT
admet-194	447	10	m.	m.	PROPN
admet-194	447	11	kondo	kondo	PROPN
admet-194	447	12	,	,	PUNCT
admet-194	447	13	s.	s.	PROPN
admet-194	447	14	uchida	uchida	PROPN
admet-194	447	15	,	,	PUNCT
admet-194	447	16	neuroscience	neuroscience	NOUN
admet-194	447	17	research	research	NOUN
admet-194	447	18	63	63	NUM
admet-194	447	19	(	(	PUNCT
admet-194	447	20	2009	2009	NUM
admet-194	447	21	)	)	PUNCT
admet-194	447	22	122	122	NUM
admet-194	447	23	-	-	SYM
admet-194	447	24	128	128	NUM
admet-194	447	25	.	.	PUNCT
admet-194	448	1	[	[	X
admet-194	448	2	142	142	NUM
admet-194	448	3	]	]	X
admet-194	448	4	s.s.d	s.s.d	ADJ
admet-194	448	5	.	.	PUNCT
admet-194	448	6	stone	stone	PROPN
admet-194	448	7	,	,	PUNCT
admet-194	448	8	c.m	c.m	PROPN
admet-194	448	9	.	.	PROPN
admet-194	448	10	teixeira	teixeira	PROPN
admet-194	448	11	,	,	PUNCT
admet-194	448	12	l.m	l.m	PROPN
admet-194	448	13	.	.	PROPN
admet-194	448	14	devito	devito	PROPN
admet-194	448	15	,	,	PUNCT
admet-194	448	16	k.	k.	PROPN
admet-194	448	17	zaslavsky	zaslavsky	PROPN
admet-194	448	18	,	,	PUNCT
admet-194	448	19	s.a	s.a	PROPN
admet-194	448	20	.	.	PROPN
admet-194	448	21	josselyn	josselyn	PROPN
admet-194	448	22	,	,	PUNCT
admet-194	449	1	a.m.	a.m.	PROPN
admet-194	449	2	lozano	lozano	PROPN
admet-194	449	3	,	,	PUNCT
admet-194	449	4	p.w	p.w	PROPN
admet-194	449	5	.	.	PROPN
admet-194	449	6	frankland	frankland	PROPN
admet-194	449	7	,	,	PUNCT
admet-194	449	8	journal	journal	NOUN
admet-194	449	9	of	of	ADP
admet-194	449	10	neuroscience	neuroscience	NOUN
admet-194	449	11	31	31	NUM
admet-194	449	12	(	(	PUNCT
admet-194	449	13	2011	2011	NUM
admet-194	449	14	)	)	PUNCT
admet-194	449	15	13469	13469	NUM
admet-194	449	16	-	-	SYM
admet-194	449	17	13484	13484	NUM
admet-194	449	18	.	.	PUNCT
admet-194	450	1	[	[	X
admet-194	450	2	143	143	NUM
admet-194	450	3	]	]	X
admet-194	450	4	i.	i.	PROPN
admet-194	450	5	arrieta	arrieta	PROPN
admet-194	450	6	-	-	PUNCT
admet-194	450	7	cruz	cruz	PROPN
admet-194	450	8	,	,	PUNCT
admet-194	450	9	c.	c.	PROPN
admet-194	450	10	pavlides	pavlide	NOUN
admet-194	450	11	,	,	PUNCT
admet-194	450	12	g.	g.	PROPN
admet-194	450	13	m.	m.	PROPN
admet-194	450	14	pasinetti	pasinetti	PROPN
admet-194	450	15	,	,	PUNCT
admet-194	450	16	translational	translational	ADJ
admet-194	450	17	neuroscience	neuroscience	NOUN
admet-194	450	18	1	1	NUM
admet-194	450	19	(	(	PUNCT
admet-194	450	20	2010	2010	NUM
admet-194	450	21	)	)	PUNCT
admet-194	450	22	188	188	NUM
admet-194	450	23	-	-	SYM
admet-194	450	24	194	194	NUM
admet-194	450	25	.	.	PUNCT
admet-194	451	1	[	[	X
admet-194	451	2	144	144	NUM
admet-194	451	3	]	]	X
admet-194	451	4	c.	c.	PROPN
admet-194	451	5	hamani	hamani	PROPN
admet-194	451	6	,	,	PUNCT
admet-194	451	7	s.	s.	PROPN
admet-194	451	8	s.	s.	PROPN
admet-194	451	9	stone	stone	PROPN
admet-194	451	10	,	,	PUNCT
admet-194	451	11	a.	a.	NOUN
admet-194	451	12	garten	garten	PROPN
admet-194	451	13	,	,	PUNCT
admet-194	451	14	a.	a.	NOUN
admet-194	451	15	m.	m.	NOUN
admet-194	451	16	lozano	lozano	PROPN
admet-194	451	17	,	,	PUNCT
admet-194	451	18	g.	g.	PROPN
admet-194	451	19	winocur	winocur	PROPN
admet-194	451	20	,	,	PUNCT
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admet-194	451	22	neurology	neurology	NOUN
admet-194	451	23	232	232	NUM
admet-194	451	24	(	(	PUNCT
admet-194	451	25	2011	2011	NUM
admet-194	451	26	)	)	PUNCT
admet-194	451	27	100104	100104	NUM
admet-194	451	28	.	.	PUNCT
admet-194	452	1	[	[	X
admet-194	452	2	145	145	NUM
admet-194	452	3	]	]	X
admet-194	452	4	h.	h.	PROPN
admet-194	452	5	toda	toda	PROPN
admet-194	452	6	,	,	PUNCT
admet-194	452	7	c.	c.	PROPN
admet-194	452	8	hamani	hamani	PROPN
admet-194	452	9	,	,	PUNCT
admet-194	452	10	a.	a.	PROPN
admet-194	452	11	p.	p.	PROPN
admet-194	452	12	fawcett	fawcett	PROPN
admet-194	452	13	,	,	PUNCT
admet-194	452	14	w.	w.	PROPN
admet-194	452	15	d.	d.	PROPN
admet-194	452	16	hutchison	hutchison	PROPN
admet-194	452	17	,	,	PUNCT
admet-194	452	18	a.	a.	PROPN
admet-194	452	19	m.	m.	PROPN
admet-194	452	20	lozano	lozano	PROPN
admet-194	452	21	,	,	PUNCT
admet-194	452	22	journal	journal	NOUN
admet-194	452	23	of	of	ADP
admet-194	452	24	neurosurgery	neurosurgery	NOUN
admet-194	452	25	108	108	NUM
admet-194	452	26	(	(	PUNCT
admet-194	452	27	2008	2008	NUM
admet-194	452	28	)	)	PUNCT
admet-194	452	29	132	132	NUM
admet-194	452	30	-	-	SYM
admet-194	452	31	138	138	NUM
admet-194	452	32	.	.	PUNCT
admet-194	453	1	[	[	X
admet-194	453	2	146	146	NUM
admet-194	453	3	]	]	X
admet-194	453	4	h.	h.	PROPN
admet-194	453	5	mccartney	mccartney	PROPN
admet-194	453	6	,	,	PUNCT
admet-194	453	7	a.	a.	PROPN
admet-194	453	8	d.	d.	PROPN
admet-194	453	9	johnson	johnson	PROPN
admet-194	453	10	,	,	PUNCT
admet-194	453	11	z.	z.	PROPN
admet-194	453	12	m.	m.	PROPN
admet-194	453	13	weil	weil	PROPN
admet-194	453	14	,	,	PUNCT
admet-194	453	15	b.	b.	PROPN
admet-194	453	16	givens	givens	PROPN
admet-194	453	17	,	,	PUNCT
admet-194	453	18	hippocampus	hippocampus	NOUN
admet-194	453	19	14	14	NUM
admet-194	453	20	(	(	PUNCT
admet-194	453	21	2004	2004	NUM
admet-194	453	22	)	)	PUNCT
admet-194	453	23	684	684	NUM
admet-194	453	24	-	-	NUM
admet-194	453	25	687	687	NUM
admet-194	453	26	.	.	PUNCT
admet-194	454	1	[	[	X
admet-194	454	2	147	147	NUM
admet-194	454	3	]	]	PUNCT
admet-194	454	4	a.	a.	NOUN
admet-194	454	5	schumacher	schumacher	PROPN
admet-194	454	6	,	,	PUNCT
admet-194	454	7	a.	a.	PROPN
admet-194	454	8	p.	p.	PROPN
admet-194	454	9	de	de	PROPN
admet-194	454	10	vasconcelos	vasconcelos	PROPN
admet-194	454	11	,	,	PUNCT
admet-194	454	12	l.	l.	PROPN
admet-194	454	13	lecourtier	lecourtier	PROPN
admet-194	454	14	,	,	PUNCT
admet-194	454	15	a.	a.	PROPN
admet-194	454	16	moser	moser	PROPN
admet-194	454	17	,	,	PUNCT
admet-194	454	18	j.	j.	PROPN
admet-194	454	19	c.	c.	PROPN
admet-194	454	20	cassel	cassel	PROPN
admet-194	454	21	,	,	PUNCT
admet-194	454	22	behavioural	behavioural	ADJ
admet-194	454	23	brain	brain	NOUN
admet-194	454	24	research	research	NOUN
admet-194	454	25	222	222	NUM
admet-194	454	26	(	(	PUNCT
admet-194	454	27	2011	2011	NUM
admet-194	454	28	)	)	PUNCT
admet-194	454	29	368	368	NUM
admet-194	454	30	-	-	SYM
admet-194	454	31	374	374	NUM
admet-194	454	32	.	.	PUNCT
admet-194	455	1	[	[	X
admet-194	455	2	148	148	NUM
admet-194	455	3	]	]	PUNCT
admet-194	455	4	z.	z.	PROPN
admet-194	455	5	m.	m.	PROPN
admet-194	455	6	williams	williams	PROPN
admet-194	455	7	,	,	PUNCT
admet-194	455	8	e.	e.	PROPN
admet-194	455	9	n.	n.	PROPN
admet-194	455	10	eskandar	eskandar	PROPN
admet-194	455	11	,	,	PUNCT
admet-194	455	12	nature	nature	NOUN
admet-194	455	13	neuroscience	neuroscience	NOUN
admet-194	455	14	9	9	NUM
admet-194	455	15	(	(	PUNCT
admet-194	455	16	2006	2006	NUM
admet-194	455	17	)	)	PUNCT
admet-194	455	18	562	562	NUM
admet-194	455	19	-	-	SYM
admet-194	455	20	568	568	NUM
admet-194	455	21	.	.	PUNCT
admet-194	456	1	[	[	X
admet-194	456	2	149	149	NUM
admet-194	456	3	]	]	X
admet-194	456	4	a.c	a.c	PROPN
admet-194	456	5	.	.	PROPN
admet-194	456	6	smith	smith	PROPN
admet-194	456	7	,	,	PUNCT
admet-194	456	8	s.a	s.a	PROPN
admet-194	456	9	.	.	PROPN
admet-194	456	10	shah	shah	PROPN
admet-194	456	11	,	,	PUNCT
admet-194	456	12	a.e	a.e	PROPN
admet-194	456	13	.	.	PROPN
admet-194	456	14	hudson	hudson	PROPN
admet-194	456	15	,	,	PUNCT
admet-194	456	16	k.p	k.p	PROPN
admet-194	456	17	.	.	PROPN
admet-194	456	18	purpura	purpura	PROPN
admet-194	456	19	,	,	PUNCT
admet-194	456	20	j.d	j.d	PROPN
admet-194	456	21	.	.	PROPN
admet-194	456	22	victor	victor	PROPN
admet-194	456	23	,	,	PUNCT
admet-194	456	24	e.n	e.n	PROPN
admet-194	456	25	.	.	PROPN
admet-194	456	26	brown	brown	PROPN
admet-194	456	27	,	,	PUNCT
admet-194	456	28	n.d	n.d	PROPN
admet-194	456	29	.	.	PROPN
admet-194	456	30	schiff	schiff	PROPN
admet-194	456	31	,	,	PUNCT
admet-194	456	32	journal	journal	NOUN
admet-194	456	33	of	of	ADP
admet-194	456	34	neuroscience	neuroscience	NOUN
admet-194	456	35	methods	method	NOUN
admet-194	456	36	183	183	NUM
admet-194	456	37	(	(	PUNCT
admet-194	456	38	2009	2009	NUM
admet-194	456	39	)	)	PUNCT
admet-194	456	40	267	267	NUM
admet-194	456	41	-	-	SYM
admet-194	456	42	276	276	NUM
admet-194	456	43	.	.	PUNCT
admet-194	457	1	[	[	X
admet-194	457	2	150	150	NUM
admet-194	457	3	]	]	PUNCT
admet-194	457	4	s.	s.	PROPN
admet-194	457	5	a.	a.	PROPN
admet-194	457	6	shah	shah	PROPN
admet-194	457	7	,	,	PUNCT
admet-194	457	8	j.	j.	PROPN
admet-194	457	9	l.	l.	PROPN
admet-194	457	10	baker	baker	PROPN
admet-194	457	11	,	,	PUNCT
admet-194	457	12	j.	j.	PROPN
admet-194	457	13	w.	w.	PROPN
admet-194	457	14	ryou	ryou	PROPN
admet-194	457	15	,	,	PUNCT
admet-194	457	16	k.	k.	PROPN
admet-194	457	17	p.	p.	PROPN
admet-194	457	18	purpura	purpura	PROPN
admet-194	457	19	,	,	PUNCT
admet-194	457	20	n.	n.	PROPN
admet-194	457	21	d.	d.	PROPN
admet-194	457	22	schiff	schiff	PROPN
admet-194	457	23	,	,	PUNCT
admet-194	457	24	conference	conference	NOUN
admet-194	457	25	proceeding	proceed	VERB
admet-194	457	26	ieee	ieee	PROPN
admet-194	457	27	engineering	engineering	NOUN
admet-194	457	28	in	in	ADP
admet-194	457	29	medicine	medicine	NOUN
admet-194	457	30	and	and	CCONJ
admet-194	457	31	biology	biology	NOUN
admet-194	457	32	society	society	NOUN
admet-194	457	33	.	.	PUNCT
admet-194	458	1	2009	2009	NUM
admet-194	458	2	(	(	PUNCT
admet-194	458	3	2009	2009	NUM
admet-194	458	4	)	)	PUNCT
admet-194	458	5	3314	3314	NUM
admet-194	458	6	-	-	SYM
admet-194	458	7	3317	3317	NUM
admet-194	458	8	.	.	PUNCT
admet-194	459	1	[	[	X
admet-194	459	2	151	151	NUM
admet-194	459	3	]	]	PUNCT
admet-194	459	4	r.	r.	PROPN
admet-194	459	5	g.	g.	PROPN
admet-194	459	6	mair	mair	PROPN
admet-194	459	7	,	,	PUNCT
admet-194	459	8	j.	j.	PROPN
admet-194	459	9	r.	r.	PROPN
admet-194	459	10	hembrook	hembrook	PROPN
admet-194	459	11	,	,	PUNCT
admet-194	459	12	journal	journal	NOUN
admet-194	459	13	of	of	ADP
admet-194	459	14	neuroscience	neuroscience	NOUN
admet-194	459	15	28	28	NUM
admet-194	459	16	(	(	PUNCT
admet-194	459	17	2008	2008	NUM
admet-194	459	18	)	)	PUNCT
admet-194	459	19	14293	14293	NUM
admet-194	459	20	-	-	SYM
admet-194	459	21	14300	14300	NUM
admet-194	459	22	.	.	PUNCT
admet-194	460	1	[	[	X
admet-194	460	2	152	152	NUM
admet-194	460	3	]	]	X
admet-194	460	4	c.	c.	PROPN
admet-194	460	5	soriano	soriano	PROPN
admet-194	460	6	-	-	PUNCT
admet-194	460	7	mas	mas	PROPN
admet-194	460	8	,	,	PUNCT
admet-194	460	9	d.	d.	PROPN
admet-194	460	10	redolar	redolar	PROPN
admet-194	460	11	-	-	PUNCT
admet-194	460	12	ripoll	ripoll	ADJ
admet-194	460	13	,	,	PUNCT
admet-194	460	14	l.	l.	PROPN
admet-194	460	15	aldavert	aldavert	PROPN
admet-194	460	16	-	-	PUNCT
admet-194	460	17	vera	vera	PROPN
admet-194	460	18	,	,	PUNCT
admet-194	460	19	i.	i.	PROPN
admet-194	460	20	morgado	morgado	PROPN
admet-194	460	21	-	-	PUNCT
admet-194	460	22	bernal	bernal	NOUN
admet-194	460	23	,	,	PUNCT
admet-194	460	24	p.	p.	PROPN
admet-194	460	25	segura	segura	NOUN
admet-194	460	26	-	-	PUNCT
admet-194	460	27	torres	torre	NOUN
admet-194	460	28	,	,	PUNCT
admet-194	460	29	behavioural	behavioural	ADJ
admet-194	460	30	brain	brain	NOUN
admet-194	460	31	research	research	NOUN
admet-194	460	32	160	160	NUM
admet-194	460	33	(	(	PUNCT
admet-194	460	34	2005	2005	NUM
admet-194	460	35	)	)	PUNCT
admet-194	460	36	141	141	NUM
admet-194	460	37	-	-	SYM
admet-194	460	38	147	147	NUM
admet-194	460	39	.	.	PUNCT
admet-194	461	1	[	[	X
admet-194	461	2	153	153	NUM
admet-194	461	3	]	]	X
admet-194	461	4	c.	c.	PROPN
admet-194	461	5	soriano	soriano	PROPN
admet-194	461	6	-	-	PUNCT
admet-194	461	7	mas	mas	PROPN
admet-194	461	8	,	,	PUNCT
admet-194	461	9	d.	d.	PROPN
admet-194	461	10	redolar	redolar	PROPN
admet-194	461	11	-	-	PUNCT
admet-194	461	12	ripoll	ripoll	ADJ
admet-194	461	13	,	,	PUNCT
admet-194	461	14	g.	g.	PROPN
admet-194	461	15	guillazo	guillazo	NOUN
admet-194	461	16	-	-	PUNCT
admet-194	461	17	blanch	blanch	NOUN
admet-194	461	18	,	,	PUNCT
admet-194	461	19	i.	i.	PROPN
admet-194	461	20	morgado	morgado	PROPN
admet-194	461	21	-	-	PUNCT
admet-194	461	22	bernal	bernal	NOUN
admet-194	461	23	,	,	PUNCT
admet-194	461	24	p.	p.	PROPN
admet-194	461	25	segura	segura	NOUN
admet-194	461	26	-	-	PUNCT
admet-194	461	27	torres	torre	NOUN
admet-194	461	28	,	,	PUNCT
admet-194	461	29	brain	brain	NOUN
admet-194	461	30	research	research	NOUN
admet-194	461	31	bulletin	bulletin	NOUN
admet-194	461	32	74	74	NUM
admet-194	461	33	(	(	PUNCT
admet-194	461	34	2007	2007	NUM
admet-194	461	35	)	)	PUNCT
admet-194	461	36	51	51	NUM
admet-194	461	37	-	-	SYM
admet-194	461	38	57	57	NUM
admet-194	461	39	.	.	PUNCT
admet-194	462	1	[	[	X
admet-194	462	2	154	154	NUM
admet-194	462	3	]	]	X
admet-194	462	4	g.	g.	PROPN
admet-194	462	5	huguet	huguet	PROPN
admet-194	462	6	,	,	PUNCT
admet-194	462	7	l.	l.	PROPN
admet-194	462	8	aldavert	aldavert	PROPN
admet-194	462	9	-	-	PUNCT
admet-194	462	10	vera	vera	PROPN
admet-194	462	11	,	,	PUNCT
admet-194	462	12	e.	e.	PROPN
admet-194	462	13	kádár	kádár	PROPN
admet-194	462	14	,	,	PUNCT
admet-194	462	15	s.	s.	PROPN
admet-194	462	16	peña	peña	PROPN
admet-194	462	17	de	de	PROPN
admet-194	462	18	ortiz	ortiz	PROPN
admet-194	462	19	,	,	PUNCT
admet-194	462	20	i.	i.	PROPN
admet-194	462	21	morgado	morgado	PROPN
admet-194	462	22	-	-	PUNCT
admet-194	462	23	bernal	bernal	NOUN
admet-194	462	24	,	,	PUNCT
admet-194	462	25	p.	p.	PROPN
admet-194	462	26	segura	segura	NOUN
admet-194	462	27	-	-	PUNCT
admet-194	462	28	torres	torre	NOUN
admet-194	462	29	,	,	PUNCT
admet-194	462	30	neuroscience	neuroscience	NOUN
admet-194	462	31	162	162	NUM
admet-194	462	32	(	(	PUNCT
admet-194	462	33	2009	2009	NUM
admet-194	462	34	)	)	PUNCT
admet-194	462	35	359	359	NUM
admet-194	462	36	-	-	SYM
admet-194	462	37	374	374	NUM
admet-194	462	38	.	.	PUNCT
admet-194	463	1	[	[	X
admet-194	463	2	155	155	NUM
admet-194	463	3	]	]	X
admet-194	463	4	e.	e.	PROPN
admet-194	463	5	kadar	kadar	PROPN
admet-194	463	6	,	,	PUNCT
admet-194	463	7	l.	l.	PROPN
admet-194	463	8	aldavert	aldavert	PROPN
admet-194	463	9	-	-	PUNCT
admet-194	463	10	vera	vera	PROPN
admet-194	463	11	,	,	PUNCT
admet-194	463	12	g.	g.	PROPN
admet-194	463	13	huguet	huguet	PROPN
admet-194	463	14	,	,	PUNCT
admet-194	463	15	d.	d.	PROPN
admet-194	463	16	costa	costa	PROPN
admet-194	463	17	-	-	PUNCT
admet-194	463	18	miserachs	miserach	NOUN
admet-194	463	19	,	,	PUNCT
admet-194	463	20	i.	i.	NOUN
admet-194	463	21	morgado	morgado	PROPN
admet-194	463	22	-	-	PUNCT
admet-194	463	23	bernal	bernal	NOUN
admet-194	463	24	,	,	PUNCT
admet-194	463	25	p.	p.	PROPN
admet-194	463	26	segura	segura	NOUN
admet-194	463	27	-	-	PUNCT
admet-194	463	28	torres	torre	NOUN
admet-194	463	29	,	,	PUNCT
admet-194	463	30	genes	gene	NOUN
admet-194	463	31	,	,	PUNCT
admet-194	463	32	brain	brain	NOUN
admet-194	463	33	and	and	CCONJ
admet-194	463	34	behavior	behavior	NOUN
admet-194	463	35	10	10	NUM
admet-194	463	36	(	(	PUNCT
admet-194	463	37	2011	2011	NUM
admet-194	463	38	)	)	PUNCT
admet-194	463	39	69	69	NUM
admet-194	463	40	-	-	SYM
admet-194	463	41	77	77	NUM
admet-194	463	42	.	.	PUNCT
admet-194	464	1	[	[	X
admet-194	464	2	156	156	NUM
admet-194	464	3	]	]	X
admet-194	464	4	h.	h.	PROPN
admet-194	464	5	w.	w.	PROPN
admet-194	464	6	querfurth	querfurth	PROPN
admet-194	464	7	,	,	PUNCT
admet-194	464	8	f.	f.	PROPN
admet-194	464	9	m.	m.	PROPN
admet-194	464	10	laferla	laferla	PROPN
admet-194	464	11	,	,	PUNCT
admet-194	464	12	new	new	PROPN
admet-194	464	13	england	england	PROPN
admet-194	464	14	journal	journal	PROPN
admet-194	464	15	of	of	ADP
admet-194	464	16	medicine	medicine	PROPN
admet-194	464	17	362	362	NUM
admet-194	464	18	(	(	PUNCT
admet-194	464	19	2010	2010	NUM
admet-194	464	20	)	)	PUNCT
admet-194	464	21	329	329	NUM
admet-194	464	22	-	-	SYM
admet-194	464	23	344	344	NUM
admet-194	464	24	.	.	PUNCT
admet-194	465	1	[	[	X
admet-194	465	2	157	157	NUM
admet-194	465	3	]	]	X
admet-194	465	4	g.	g.	PROPN
admet-194	465	5	deuschl	deuschl	PROPN
admet-194	465	6	,	,	PUNCT
admet-194	465	7	c.	c.	PROPN
admet-194	465	8	schade	schade	PROPN
admet-194	465	9	-	-	PUNCT
admet-194	465	10	brittinger	brittinger	NOUN
admet-194	465	11	,	,	PUNCT
admet-194	465	12	p.	p.	NOUN
admet-194	465	13	krack	krack	NOUN
admet-194	465	14	,	,	PUNCT
admet-194	465	15	j.	j.	PROPN
admet-194	465	16	volkmann	volkmann	PROPN
admet-194	465	17	,	,	PUNCT
admet-194	465	18	h.	h.	PROPN
admet-194	465	19	schäfer	schäfer	PROPN
admet-194	465	20	,	,	PUNCT
admet-194	465	21	k.	k.	PROPN
admet-194	465	22	bötzel	bötzel	PROPN
admet-194	465	23	,	,	PUNCT
admet-194	465	24	c.	c.	PROPN
admet-194	465	25	daniels	daniels	PROPN
admet-194	465	26	,	,	PUNCT
admet-194	465	27	a.	a.	NOUN
admet-194	465	28	deutschländer	deutschländer	PROPN
admet-194	465	29	,	,	PUNCT
admet-194	465	30	u.	u.	PROPN
admet-194	465	31	dillmann	dillmann	PROPN
admet-194	465	32	,	,	PUNCT
admet-194	465	33	w.	w.	PROPN
admet-194	465	34	eisner	eisner	PROPN
admet-194	465	35	,	,	PUNCT
admet-194	465	36	d.	d.	PROPN
admet-194	465	37	gruber	gruber	PROPN
admet-194	465	38	,	,	PUNCT
admet-194	465	39	w.	w.	PROPN
admet-194	465	40	hamel	hamel	PROPN
admet-194	465	41	,	,	PUNCT
admet-194	465	42	j.	j.	PROPN
admet-194	465	43	herzog	herzog	PROPN
admet-194	465	44	,	,	PUNCT
admet-194	465	45	r.	r.	PROPN
admet-194	465	46	hilker	hilker	PROPN
admet-194	465	47	,	,	PUNCT
admet-194	465	48	s.	s.	PROPN
admet-194	465	49	klebe	klebe	PROPN
admet-194	465	50	,	,	PUNCT
admet-194	465	51	m.	m.	PROPN
admet-194	465	52	kloss	kloss	PROPN
admet-194	465	53	,	,	PUNCT
admet-194	465	54	j.	j.	PROPN
admet-194	465	55	koy	koy	PROPN
admet-194	465	56	,	,	PUNCT
admet-194	465	57	m.	m.	NOUN
admet-194	465	58	krause	krause	PROPN
admet-194	465	59	,	,	PUNCT
admet-194	465	60	a.	a.	PROPN
admet-194	465	61	kupsch	kupsch	PROPN
admet-194	465	62	,	,	PUNCT
admet-194	465	63	d.	d.	PROPN
admet-194	465	64	lorenz	lorenz	PROPN
admet-194	465	65	,	,	PUNCT
admet-194	465	66	s.	s.	PROPN
admet-194	465	67	lorenzl	lorenzl	PROPN
admet-194	465	68	,	,	PUNCT
admet-194	465	69	h.m	h.m	PROPN
admet-194	465	70	.	.	PROPN
admet-194	465	71	mehdorn	mehdorn	PROPN
admet-194	465	72	,	,	PUNCT
admet-194	465	73	j.r	j.r	PROPN
admet-194	465	74	.	.	PROPN
admet-194	465	75	moringlane	moringlane	PROPN
admet-194	465	76	,	,	PUNCT
admet-194	465	77	w.	w.	PROPN
admet-194	465	78	oertel	oertel	PROPN
admet-194	465	79	,	,	PUNCT
admet-194	465	80	m.o	m.o	PROPN
admet-194	465	81	.	.	PROPN
admet-194	465	82	pinsker	pinsker	PROPN
admet-194	465	83	,	,	PUNCT
admet-194	465	84	h.	h.	PROPN
admet-194	465	85	reichmann	reichmann	PROPN
admet-194	465	86	,	,	PUNCT
admet-194	465	87	a.	a.	NOUN
admet-194	465	88	reuss	reuss	PROPN
admet-194	465	89	,	,	PUNCT
admet-194	465	90	g.h	g.h	PROPN
admet-194	465	91	.	.	PROPN
admet-194	465	92	schneider	schneider	PROPN
admet-194	465	93	,	,	PUNCT
admet-194	465	94	a.	a.	NOUN
admet-194	465	95	schnitzler	schnitzler	PROPN
admet-194	465	96	,	,	PUNCT
admet-194	465	97	u.	u.	PROPN
admet-194	465	98	steude	steude	PROPN
admet-194	465	99	,	,	PUNCT
admet-194	465	100	v.	v.	PROPN
admet-194	465	101	sturm	sturm	PROPN
admet-194	465	102	,	,	PUNCT
admet-194	465	103	l.	l.	PROPN
admet-194	465	104	timmermann	timmermann	PROPN
admet-194	465	105	,	,	PUNCT
admet-194	465	106	v.	v.	ADP
admet-194	465	107	tronnier	tronnier	NOUN
admet-194	465	108	,	,	PUNCT
admet-194	465	109	t.	t.	PROPN
admet-194	465	110	trottenberg	trottenberg	PROPN
admet-194	465	111	,	,	PUNCT
admet-194	465	112	l.	l.	PROPN
admet-194	465	113	wojtecki	wojtecki	PROPN
admet-194	465	114	,	,	PUNCT
admet-194	465	115	e.	e.	PROPN
admet-194	465	116	wolf	wolf	PROPN
admet-194	465	117	,	,	PUNCT
admet-194	465	118	w.	w.	PROPN
admet-194	465	119	poewe	poewe	PROPN
admet-194	465	120	,	,	PUNCT
admet-194	465	121	j.	j.	PROPN
admet-194	465	122	voges	voge	VERB
admet-194	465	123	;	;	PUNCT
admet-194	465	124	german	german	ADJ
admet-194	465	125	parkinson	parkinson	NOUN
admet-194	465	126	study	study	NOUN
admet-194	465	127	group	group	NOUN
admet-194	465	128	,	,	PUNCT
admet-194	465	129	neurostimulation	neurostimulation	NOUN
admet-194	465	130	section	section	NOUN
admet-194	465	131	,	,	PUNCT
admet-194	465	132	new	new	PROPN
admet-194	465	133	england	england	PROPN
admet-194	465	134	journal	journal	PROPN
admet-194	465	135	of	of	ADP
admet-194	465	136	medicine	medicine	NOUN
admet-194	465	137	355	355	NUM
admet-194	465	138	(	(	PUNCT
admet-194	465	139	2006	2006	NUM
admet-194	465	140	)	)	PUNCT
admet-194	465	141	896	896	NUM
admet-194	465	142	-	-	SYM
admet-194	465	143	908	908	NUM
admet-194	465	144	.	.	PUNCT
admet-194	466	1	[	[	X
admet-194	466	2	158	158	NUM
admet-194	466	3	]	]	X
admet-194	466	4	j.	j.	PROPN
admet-194	466	5	voges	voge	VERB
admet-194	466	6	,	,	PUNCT
admet-194	466	7	y.	y.	NOUN
admet-194	466	8	waerzeggers	waerzegger	NOUN
admet-194	466	9	,	,	PUNCT
admet-194	466	10	m.	m.	PROPN
admet-194	466	11	maarouf	maarouf	PROPN
admet-194	466	12	,	,	PUNCT
admet-194	466	13	r.	r.	PROPN
admet-194	466	14	lehrke	lehrke	PROPN
admet-194	466	15	,	,	PUNCT
admet-194	466	16	a.	a.	NOUN
admet-194	466	17	koulousakis	koulousakis	PROPN
admet-194	466	18	,	,	PUNCT
admet-194	466	19	d.	d.	PROPN
admet-194	466	20	lenartz	lenartz	PROPN
admet-194	466	21	,	,	PUNCT
admet-194	466	22	v.	v.	PROPN
admet-194	466	23	sturm	sturm	PROPN
admet-194	466	24	,	,	PUNCT
admet-194	466	25	journal	journal	NOUN
admet-194	466	26	of	of	ADP
admet-194	466	27	neurology	neurology	NOUN
admet-194	466	28	,	,	PUNCT
admet-194	466	29	neurosurgery	neurosurgery	PROPN
admet-194	466	30	&	&	CCONJ
admet-194	466	31	psychiatry	psychiatry	PROPN
admet-194	466	32	77	77	NUM
admet-194	466	33	(	(	PUNCT
admet-194	466	34	2006	2006	NUM
admet-194	466	35	)	)	PUNCT
admet-194	466	36	868	868	NUM
admet-194	466	37	-	-	SYM
admet-194	466	38	872	872	NUM
admet-194	466	39	.	.	PUNCT
admet-194	467	1	©	©	PROPN
admet-194	467	2	2015	2015	NUM
admet-194	467	3	by	by	ADP
admet-194	467	4	the	the	DET
admet-194	467	5	authors	author	NOUN
admet-194	467	6	;	;	PUNCT
admet-194	467	7	licensee	licensee	PROPN
admet-194	467	8	iapc	iapc	PROPN
admet-194	467	9	,	,	PUNCT
admet-194	467	10	zagreb	zagreb	PROPN
admet-194	467	11	,	,	PUNCT
admet-194	467	12	croatia	croatia	PROPN
admet-194	467	13	.	.	PUNCT
admet-194	468	1	this	this	DET
admet-194	468	2	article	article	NOUN
admet-194	468	3	is	be	AUX
admet-194	468	4	an	an	DET
admet-194	468	5	open	open	ADJ
admet-194	468	6	-	-	PUNCT
admet-194	468	7	access	access	NOUN
admet-194	468	8	article	article	NOUN
admet-194	468	9	distributed	distribute	VERB
admet-194	468	10	under	under	ADP
admet-194	468	11	the	the	DET
admet-194	468	12	terms	term	NOUN
admet-194	468	13	and	and	CCONJ
admet-194	468	14	conditions	condition	NOUN
admet-194	468	15	of	of	ADP
admet-194	468	16	the	the	DET
admet-194	468	17	creative	creative	ADJ
admet-194	468	18	commons	common	NOUN
admet-194	468	19	attribution	attribution	NOUN
admet-194	468	20	license(http://creativecommons.org	license(http://creativecommons.org	X
admet-194	468	21	/	/	SYM
admet-194	468	22	licenses	license	NOUN
admet-194	468	23	/	/	SYM
admet-194	468	24	by/3.0/	by/3.0/	NOUN
admet-194	468	25	)	)	PUNCT
admet-194	468	26	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN