id sid tid token lemma pos admet-2022 1 1 food food NOUN admet-2022 1 2 and and CCONJ admet-2022 1 3 bile bile NOUN admet-2022 1 4 micelle micelle NOUN admet-2022 1 5 binding bind VERB admet-2022 1 6 of of ADP admet-2022 1 7 quaternary quaternary ADJ admet-2022 1 8 ammonium ammonium NOUN admet-2022 1 9 compounds compound NOUN admet-2022 1 10 doi doi NOUN admet-2022 1 11 : : PUNCT admet-2022 1 12 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 1 13 167 167 NUM admet-2022 1 14 admet admet X admet-2022 1 15 & & CCONJ admet-2022 1 16 dmpk dmpk PROPN admet-2022 1 17 12(1 12(1 PROPN admet-2022 1 18 ) ) PUNCT admet-2022 1 19 ( ( PUNCT admet-2022 1 20 2024 2024 NUM admet-2022 1 21 ) ) PUNCT admet-2022 1 22 167 167 NUM admet-2022 1 23 - - SYM admet-2022 1 24 176 176 NUM admet-2022 1 25 ; ; PUNCT admet-2022 1 26 doi doi NOUN admet-2022 1 27 : : PUNCT admet-2022 1 28 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 1 29 open open ADJ admet-2022 1 30 access access NOUN admet-2022 1 31 : : PUNCT admet-2022 1 32 issn issn PROPN admet-2022 1 33 : : PUNCT admet-2022 1 34 1848 1848 NUM admet-2022 1 35 - - SYM admet-2022 1 36 7718 7718 NUM admet-2022 1 37 http://www.pub.iapchem.org/ojs/index.php/admet/index http://www.pub.iapchem.org/ojs/index.php/admet/index NOUN admet-2022 1 38 original original ADJ admet-2022 1 39 scientific scientific ADJ admet-2022 1 40 paper paper NOUN admet-2022 1 41 oral oral ADJ admet-2022 1 42 bioavailability bioavailability NOUN admet-2022 1 43 enhancement enhancement NOUN admet-2022 1 44 of of ADP admet-2022 1 45 doxazosin doxazosin PROPN admet-2022 1 46 mesylate mesylate NOUN admet-2022 1 47 : : PUNCT admet-2022 1 48 nanosuspension nanosuspension NOUN admet-2022 1 49 versus versus ADP admet-2022 1 50 self self NOUN admet-2022 1 51 - - PUNCT admet-2022 1 52 nanoemulsifying nanoemulsifye VERB admet-2022 1 53 drug drug NOUN admet-2022 1 54 delivery delivery NOUN admet-2022 1 55 systems system NOUN admet-2022 1 56 al al PROPN admet-2022 1 57 zahraa zahraa PROPN admet-2022 1 58 g. g. PROPN admet-2022 1 59 al al PROPN admet-2022 1 60 ashmawy1 ashmawy1 PROPN admet-2022 1 61 , , PUNCT admet-2022 1 62 mohammad mohammad PROPN admet-2022 1 63 h. h. PROPN admet-2022 1 64 alyami2 alyami2 PROPN admet-2022 1 65 , , PUNCT admet-2022 1 66 noura noura NOUN admet-2022 1 67 g. g. PROPN admet-2022 1 68 eissa3,4 eissa3,4 PROPN admet-2022 1 69 , , PUNCT admet-2022 1 70 gehan gehan PROPN admet-2022 1 71 f. f. PROPN admet-2022 1 72 balata4,5 balata4,5 PROPN admet-2022 1 73 and and CCONJ admet-2022 1 74 hanan hanan PROPN admet-2022 1 75 m. m. PROPN admet-2022 1 76 el el PROPN admet-2022 1 77 nahas4 nahas4 PROPN admet-2022 1 78 , , PUNCT admet-2022 1 79 * * PROPN admet-2022 1 80 1department 1department NUM admet-2022 1 81 of of ADP admet-2022 1 82 pharmaceutics pharmaceutic NOUN admet-2022 1 83 and and CCONJ admet-2022 1 84 pharmaceutical pharmaceutical NOUN admet-2022 1 85 technology technology NOUN admet-2022 1 86 , , PUNCT admet-2022 1 87 faculty faculty NOUN admet-2022 1 88 of of ADP admet-2022 1 89 pharmacy pharmacy NOUN admet-2022 1 90 , , PUNCT admet-2022 1 91 heliopolis heliopolis PROPN admet-2022 1 92 university university PROPN admet-2022 1 93 , , PUNCT admet-2022 1 94 cairo cairo PROPN admet-2022 1 95 11785 11785 NUM admet-2022 1 96 , , PUNCT admet-2022 1 97 egypt egypt PROPN admet-2022 1 98 2department 2department NUM admet-2022 1 99 of of ADP admet-2022 1 100 pharmaceutics pharmaceutic NOUN admet-2022 1 101 , , PUNCT admet-2022 1 102 college college NOUN admet-2022 1 103 of of ADP admet-2022 1 104 pharmacy pharmacy NOUN admet-2022 1 105 , , PUNCT admet-2022 1 106 najran najran ADJ admet-2022 1 107 university university NOUN admet-2022 1 108 , , PUNCT admet-2022 1 109 najran najran NOUN admet-2022 1 110 66462 66462 NUM admet-2022 1 111 , , PUNCT admet-2022 1 112 saudi saudi PROPN admet-2022 1 113 arabia arabia PROPN admet-2022 1 114 3badr 3badr NUM admet-2022 1 115 university university NOUN admet-2022 1 116 in in ADP admet-2022 1 117 cairo cairo PROPN admet-2022 1 118 research research NOUN admet-2022 1 119 center center PROPN admet-2022 1 120 , , PUNCT admet-2022 1 121 badr badr PROPN admet-2022 1 122 university university PROPN admet-2022 1 123 in in ADP admet-2022 1 124 cairo cairo PROPN admet-2022 1 125 , , PUNCT admet-2022 1 126 badr badr PROPN admet-2022 1 127 city city PROPN admet-2022 1 128 , , PUNCT admet-2022 1 129 cairo cairo PROPN admet-2022 1 130 11829 11829 NUM admet-2022 1 131 , , PUNCT admet-2022 1 132 egypt egypt PROPN admet-2022 1 133 4department 4department NUM admet-2022 1 134 of of ADP admet-2022 1 135 pharmaceutics pharmaceutic NOUN admet-2022 1 136 and and CCONJ admet-2022 1 137 industrial industrial ADJ admet-2022 1 138 pharmacy pharmacy NOUN admet-2022 1 139 , , PUNCT admet-2022 1 140 faculty faculty NOUN admet-2022 1 141 of of ADP admet-2022 1 142 pharmacy pharmacy NOUN admet-2022 1 143 , , PUNCT admet-2022 1 144 zagazig zagazig PROPN admet-2022 1 145 university university PROPN admet-2022 1 146 , , PUNCT admet-2022 1 147 zagazig zagazig PROPN admet-2022 1 148 44519 44519 NUM admet-2022 1 149 , , PUNCT admet-2022 1 150 egypt egypt PROPN admet-2022 1 151 5pharmacy 5pharmacy NUM admet-2022 1 152 practice practice NOUN admet-2022 1 153 department department NOUN admet-2022 1 154 , , PUNCT admet-2022 1 155 faculty faculty NOUN admet-2022 1 156 of of ADP admet-2022 1 157 pharmacy pharmacy NOUN admet-2022 1 158 , , PUNCT admet-2022 1 159 heliopolis heliopolis PROPN admet-2022 1 160 university university PROPN admet-2022 1 161 , , PUNCT admet-2022 1 162 cairo cairo PROPN admet-2022 1 163 11785 11785 NUM admet-2022 1 164 , , PUNCT admet-2022 1 165 egypt egypt PROPN admet-2022 1 166 * * PUNCT admet-2022 1 167 corresponding correspond VERB admet-2022 1 168 author author NOUN admet-2022 1 169 : : PUNCT admet-2022 1 170 e e NOUN admet-2022 1 171 - - NOUN admet-2022 1 172 mail mail NOUN admet-2022 1 173 : : PUNCT admet-2022 1 174 zahraa_ashmawy@yahoo.com zahraa_ashmawy@yahoo.com NOUN admet-2022 1 175 ; ; PUNCT admet-2022 1 176 tel tel PROPN admet-2022 1 177 . . PROPN admet-2022 1 178 : : PUNCT admet-2022 1 179 01018377688 01018377688 NUM admet-2022 1 180 ; ; PUNCT admet-2022 1 181 fax fax NOUN admet-2022 1 182 : : PUNCT admet-2022 1 183 02/26588154 02/26588154 NOUN admet-2022 1 184 received receive VERB admet-2022 1 185 : : PUNCT admet-2022 1 186 august august PROPN admet-2022 1 187 13 13 NUM admet-2022 1 188 , , PUNCT admet-2022 1 189 2023 2023 NUM admet-2022 1 190 ; ; PUNCT admet-2022 1 191 revised revise VERB admet-2022 1 192 : : PUNCT admet-2022 1 193 october october PROPN admet-2022 1 194 29 29 NUM admet-2022 1 195 , , PUNCT admet-2022 1 196 2023 2023 NUM admet-2022 1 197 ; ; PUNCT admet-2022 1 198 published publish VERB admet-2022 1 199 : : PUNCT admet-2022 1 200 november november PROPN admet-2022 1 201 3 3 NUM admet-2022 1 202 , , PUNCT admet-2022 1 203 2023 2023 NUM admet-2022 1 204 abstract abstract ADJ admet-2022 1 205 background background NOUN admet-2022 1 206 and and CCONJ admet-2022 1 207 purpose purpose NOUN admet-2022 1 208 : : PUNCT admet-2022 1 209 doxazosin doxazosin VERB admet-2022 1 210 mesylate mesylate NOUN admet-2022 1 211 ( ( PUNCT admet-2022 1 212 dox dox NOUN admet-2022 1 213 ) ) PUNCT admet-2022 1 214 is be AUX admet-2022 1 215 an an DET admet-2022 1 216 antihypertensive antihypertensive ADJ admet-2022 1 217 drug drug NOUN admet-2022 1 218 that that PRON admet-2022 1 219 possesses possess VERB admet-2022 1 220 poor poor ADJ admet-2022 1 221 water water NOUN admet-2022 1 222 solubility solubility NOUN admet-2022 1 223 and and CCONJ admet-2022 1 224 , , PUNCT admet-2022 1 225 hence hence ADV admet-2022 1 226 , , PUNCT admet-2022 1 227 poor poor ADJ admet-2022 1 228 release release NOUN admet-2022 1 229 properties property NOUN admet-2022 1 230 . . PUNCT admet-2022 2 1 both both DET admet-2022 2 2 nanosuspensions nanosuspension NOUN admet-2022 2 3 and and CCONJ admet-2022 2 4 self self NOUN admet-2022 2 5 - - PUNCT admet-2022 2 6 nanoemulsifying nanoemulsifye VERB admet-2022 2 7 drug drug NOUN admet-2022 2 8 delivery delivery NOUN admet-2022 2 9 systems system NOUN admet-2022 2 10 ( ( PUNCT admet-2022 2 11 snedds snedds PROPN admet-2022 2 12 ) ) PUNCT admet-2022 2 13 are be AUX admet-2022 2 14 becoming become VERB admet-2022 2 15 nanotechnology nanotechnology NOUN admet-2022 2 16 techniques technique NOUN admet-2022 2 17 for for ADP admet-2022 2 18 the the DET admet-2022 2 19 enhancement enhancement NOUN admet-2022 2 20 of of ADP admet-2022 2 21 water water NOUN admet-2022 2 22 solubility solubility NOUN admet-2022 2 23 of of ADP admet-2022 2 24 different different ADJ admet-2022 2 25 drugs drug NOUN admet-2022 2 26 . . PUNCT admet-2022 3 1 experimental experimental ADJ admet-2022 3 2 approach approach NOUN admet-2022 3 3 : : PUNCT admet-2022 3 4 the the DET admet-2022 3 5 study study NOUN admet-2022 3 6 's 's PART admet-2022 3 7 goal goal NOUN admet-2022 3 8 was be AUX admet-2022 3 9 to to PART admet-2022 3 10 identify identify VERB admet-2022 3 11 the the DET admet-2022 3 12 best good ADJ admet-2022 3 13 drug drug NOUN admet-2022 3 14 delivery delivery NOUN admet-2022 3 15 system system NOUN admet-2022 3 16 able able ADJ admet-2022 3 17 to to PART admet-2022 3 18 enhance enhance VERB admet-2022 3 19 the the DET admet-2022 3 20 release release NOUN admet-2022 3 21 and and CCONJ admet-2022 3 22 antihypertensive antihypertensive ADJ admet-2022 3 23 effect effect NOUN admet-2022 3 24 of of ADP admet-2022 3 25 dox dox NOUN admet-2022 3 26 by by ADP admet-2022 3 27 comparing compare VERB admet-2022 3 28 the the DET admet-2022 3 29 physical physical ADJ admet-2022 3 30 characteristics characteristic NOUN admet-2022 3 31 such such ADJ admet-2022 3 32 as as ADP admet-2022 3 33 particle particle NOUN admet-2022 3 34 size size NOUN admet-2022 3 35 , , PUNCT admet-2022 3 36 zeta zeta NOUN admet-2022 3 37 potential potential NOUN admet-2022 3 38 , , PUNCT admet-2022 3 39 entrapment entrapment ADJ admet-2022 3 40 efficiency efficiency NOUN admet-2022 3 41 , , PUNCT admet-2022 3 42 release release NOUN admet-2022 3 43 rate rate NOUN admet-2022 3 44 , , PUNCT admet-2022 3 45 and and CCONJ admet-2022 3 46 main main ADJ admet-2022 3 47 arterial arterial ADJ admet-2022 3 48 blood blood NOUN admet-2022 3 49 pressure pressure NOUN admet-2022 3 50 of of ADP admet-2022 3 51 doxloaded doxloaded ADJ admet-2022 3 52 nanosuspensions nanosuspension NOUN admet-2022 3 53 and and CCONJ admet-2022 3 54 snedds snedd VERB admet-2022 3 55 in in ADP admet-2022 3 56 liquid liquid ADJ admet-2022 3 57 and and CCONJ admet-2022 3 58 solid solid ADJ admet-2022 3 59 form form NOUN admet-2022 3 60 . . PUNCT admet-2022 4 1 key key ADJ admet-2022 4 2 results result NOUN admet-2022 4 3 : : PUNCT admet-2022 4 4 dox dox NOUN admet-2022 4 5 nanosuspension nanosuspension NOUN admet-2022 4 6 preparation preparation NOUN admet-2022 4 7 had have AUX admet-2022 4 8 a a DET admet-2022 4 9 particle particle NOUN admet-2022 4 10 size size NOUN admet-2022 4 11 of of ADP admet-2022 4 12 385±13 385±13 PROPN admet-2022 4 13 nm nm NOUN admet-2022 4 14 , , PUNCT admet-2022 4 15 poly poly ADJ admet-2022 4 16 - - PUNCT admet-2022 4 17 dispersity dispersity NOUN admet-2022 4 18 index index NOUN admet-2022 4 19 of of ADP admet-2022 4 20 0.049±3 0.049±3 PROPN admet-2022 4 21 , , PUNCT admet-2022 4 22 zeta zeta NOUN admet-2022 4 23 potential potential NOUN admet-2022 4 24 of of ADP admet-2022 4 25 50 50 NUM admet-2022 4 26 ± ± NUM admet-2022 4 27 4 4 NUM admet-2022 4 28 mv mv NOUN admet-2022 4 29 and and CCONJ admet-2022 4 30 drug drug NOUN admet-2022 4 31 release release NOUN admet-2022 4 32 after after ADP admet-2022 4 33 20 20 NUM admet-2022 4 34 min min NOUN admet-2022 4 35 ( ( PUNCT admet-2022 4 36 91±0.43 91±0.43 NUM admet-2022 4 37 % % NOUN admet-2022 4 38 ) ) PUNCT admet-2022 4 39 . . PUNCT admet-2022 5 1 liquid liquid NOUN admet-2022 5 2 snedds snedd NOUN admet-2022 5 3 had have VERB admet-2022 5 4 a a DET admet-2022 5 5 droplet droplet ADJ admet-2022 5 6 size size NOUN admet-2022 5 7 of of ADP admet-2022 5 8 224±15 224±15 NUM admet-2022 5 9 nm nm ADJ admet-2022 5 10 , , PUNCT admet-2022 5 11 poly poly ADJ admet-2022 5 12 - - PUNCT admet-2022 5 13 dispersity dispersity NOUN admet-2022 5 14 index index NOUN admet-2022 5 15 of of ADP admet-2022 5 16 ( ( PUNCT admet-2022 5 17 0.470±0.01 0.470±0.01 NOUN admet-2022 5 18 ) ) PUNCT admet-2022 5 19 , , PUNCT admet-2022 5 20 zeta zeta NOUN admet-2022 5 21 potential potential NOUN admet-2022 5 22 of of ADP admet-2022 5 23 -5±0.10 -5±0.10 NOUN admet-2022 5 24 mv mv PROPN admet-2022 5 25 and and CCONJ admet-2022 5 26 dr20min dr20min PROPN admet-2022 5 27 of of ADP admet-2022 5 28 93±4 93±4 NOUN admet-2022 5 29 % % NOUN admet-2022 5 30 . . PUNCT admet-2022 6 1 solid solid ADJ admet-2022 6 2 sedds sedd NOUN admet-2022 6 3 showed show VERB admet-2022 6 4 particle particle NOUN admet-2022 6 5 size size NOUN admet-2022 6 6 of of ADP admet-2022 6 7 79±14 79±14 NUM admet-2022 6 8 nm nm NOUN admet-2022 6 9 , , PUNCT admet-2022 6 10 poly poly ADJ admet-2022 6 11 - - PUNCT admet-2022 6 12 dispersity dispersity NOUN admet-2022 6 13 index index NOUN admet-2022 6 14 of of ADP admet-2022 6 15 1±0.00 1±0.00 NUM admet-2022 6 16 , , PUNCT admet-2022 6 17 a a DET admet-2022 6 18 zeta zeta NOUN admet-2022 6 19 potential potential NOUN admet-2022 6 20 of of ADP admet-2022 6 21 -18 -18 ADP admet-2022 6 22 ±0.26 ±0.26 ADJ admet-2022 6 23 mv mv PROPN admet-2022 6 24 and and CCONJ admet-2022 6 25 dr20min dr20min PROPN admet-2022 6 26 of of ADP admet-2022 6 27 100 100 NUM admet-2022 6 28 ±2.72 ±2.72 NOUN admet-2022 6 29 % % NOUN admet-2022 6 30 . . PUNCT admet-2022 7 1 conclusion conclusion NOUN admet-2022 7 2 : : PUNCT admet-2022 7 3 finally finally ADV admet-2022 7 4 , , PUNCT admet-2022 7 5 in in ADP admet-2022 7 6 terms term NOUN admet-2022 7 7 of of ADP admet-2022 7 8 the the DET admet-2022 7 9 mean mean ADJ admet-2022 7 10 arterial arterial ADJ admet-2022 7 11 blood blood NOUN admet-2022 7 12 pressure pressure NOUN admet-2022 7 13 lowering lower VERB admet-2022 7 14 , , PUNCT admet-2022 7 15 solid solid ADJ admet-2022 7 16 snedds snedd NOUN admet-2022 7 17 performed perform VERB admet-2022 7 18 better well ADJ admet-2022 7 19 effect effect NOUN admet-2022 7 20 than than ADP admet-2022 7 21 both both PRON admet-2022 7 22 liquid liquid ADJ admet-2022 7 23 snedds snedd NOUN admet-2022 7 24 and and CCONJ admet-2022 7 25 nanosuspension nanosuspension NOUN admet-2022 7 26 ( ( PUNCT admet-2022 7 27 p p X admet-2022 7 28 > > X admet-2022 7 29 0.05 0.05 NUM admet-2022 7 30 ) ) PUNCT admet-2022 7 31 . . PUNCT admet-2022 8 1 © © PROPN admet-2022 8 2 2023 2023 NUM admet-2022 8 3 by by ADP admet-2022 8 4 the the DET admet-2022 8 5 authors author NOUN admet-2022 8 6 . . PUNCT admet-2022 9 1 this this DET admet-2022 9 2 article article NOUN admet-2022 9 3 is be AUX admet-2022 9 4 an an DET admet-2022 9 5 open open ADJ admet-2022 9 6 - - PUNCT admet-2022 9 7 access access NOUN admet-2022 9 8 article article NOUN admet-2022 9 9 distributed distribute VERB admet-2022 9 10 under under ADP admet-2022 9 11 the the DET admet-2022 9 12 terms term NOUN admet-2022 9 13 and and CCONJ admet-2022 9 14 conditions condition NOUN admet-2022 9 15 of of ADP admet-2022 9 16 the the DET admet-2022 9 17 creative creative ADJ admet-2022 9 18 commons common NOUN admet-2022 9 19 attribution attribution NOUN admet-2022 9 20 license license NOUN admet-2022 9 21 ( ( PUNCT admet-2022 9 22 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ PROPN admet-2022 9 23 ) ) PUNCT admet-2022 9 24 . . PUNCT admet-2022 10 1 keywords keyword VERB admet-2022 10 2 hypertension hypertension NOUN admet-2022 10 3 , , PUNCT admet-2022 10 4 solubility solubility NOUN admet-2022 10 5 , , PUNCT admet-2022 10 6 zeta zeta NOUN admet-2022 10 7 potential potential NOUN admet-2022 10 8 , , PUNCT admet-2022 10 9 mean mean VERB admet-2022 10 10 arterial arterial ADJ admet-2022 10 11 blood blood NOUN admet-2022 10 12 pressure pressure NOUN admet-2022 10 13 , , PUNCT admet-2022 10 14 dissolution dissolution ADJ admet-2022 10 15 introduction introduction NOUN admet-2022 10 16 there there PRON admet-2022 10 17 are be VERB admet-2022 10 18 many many ADJ admet-2022 10 19 different different ADJ admet-2022 10 20 pharmacological pharmacological NOUN admet-2022 10 21 compounds compound NOUN admet-2022 10 22 and and CCONJ admet-2022 10 23 drug drug NOUN admet-2022 10 24 candidates candidate NOUN admet-2022 10 25 in in ADP admet-2022 10 26 the the DET admet-2022 10 27 world world NOUN admet-2022 10 28 of of ADP admet-2022 10 29 pharmaceutical pharmaceutical NOUN admet-2022 10 30 product product NOUN admet-2022 10 31 development development NOUN admet-2022 10 32 , , PUNCT admet-2022 10 33 however however ADV admet-2022 10 34 , , PUNCT admet-2022 10 35 despite despite SCONJ admet-2022 10 36 their their PRON admet-2022 10 37 therapeutic therapeutic ADJ admet-2022 10 38 efficacy efficacy NOUN admet-2022 10 39 , , PUNCT admet-2022 10 40 they they PRON admet-2022 10 41 frequently frequently ADV admet-2022 10 42 have have VERB admet-2022 10 43 poor poor ADJ admet-2022 10 44 water water NOUN admet-2022 10 45 solubility solubility NOUN admet-2022 10 46 , , PUNCT admet-2022 10 47 so so CCONJ admet-2022 10 48 the the DET admet-2022 10 49 rate rate NOUN admet-2022 10 50 of of ADP admet-2022 10 51 drug drug NOUN admet-2022 10 52 release release NOUN admet-2022 10 53 and and CCONJ admet-2022 10 54 absorption absorption NOUN admet-2022 10 55 will will AUX admet-2022 10 56 be be AUX admet-2022 10 57 limited limit VERB admet-2022 10 58 , , PUNCT admet-2022 10 59 reflecting reflect VERB admet-2022 10 60 on on ADP admet-2022 10 61 the the DET admet-2022 10 62 therapeutic therapeutic ADJ admet-2022 10 63 drug drug NOUN admet-2022 10 64 effect effect NOUN admet-2022 10 65 . . PUNCT admet-2022 11 1 for for ADP admet-2022 11 2 improving improve VERB admet-2022 11 3 the the DET admet-2022 11 4 low low ADJ admet-2022 11 5 solubility solubility NOUN admet-2022 11 6 and and CCONJ admet-2022 11 7 release release NOUN admet-2022 11 8 rate rate NOUN admet-2022 11 9 of of ADP admet-2022 11 10 hydrophobic hydrophobic NOUN admet-2022 11 11 drugs drug NOUN admet-2022 11 12 , , PUNCT admet-2022 11 13 many many ADJ admet-2022 11 14 strategies strategy NOUN admet-2022 11 15 , , PUNCT admet-2022 11 16 including include VERB admet-2022 11 17 solid solid ADJ admet-2022 11 18 dispersion dispersion NOUN admet-2022 11 19 [ [ X admet-2022 11 20 1 1 NUM admet-2022 11 21 ] ] PUNCT admet-2022 11 22 , , PUNCT admet-2022 11 23 micronization micronization NOUN admet-2022 11 24 [ [ X admet-2022 11 25 2 2 NUM admet-2022 11 26 ] ] PUNCT admet-2022 11 27 , , PUNCT admet-2022 11 28 ph ph ADJ admet-2022 11 29 modification modification NOUN admet-2022 11 30 [ [ X admet-2022 11 31 3 3 NUM admet-2022 11 32 ] ] PUNCT admet-2022 11 33 , , PUNCT admet-2022 11 34 crystal crystal NOUN admet-2022 11 35 modification modification NOUN admet-2022 11 36 [ [ X admet-2022 11 37 4 4 NUM admet-2022 11 38 ] ] PUNCT admet-2022 11 39 , , PUNCT admet-2022 11 40 and and CCONJ admet-2022 11 41 self self NOUN admet-2022 11 42 - - PUNCT admet-2022 11 43 emulsifying emulsify VERB admet-2022 11 44 drug drug NOUN admet-2022 11 45 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 11 46 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 11 47 http://www.pub.iapchem.org/ojs/index.php/admet/index http://www.pub.iapchem.org/ojs/index.php/admet/index NOUN admet-2022 11 48 mailto:zahraa_ashmawy@yahoo.com mailto:zahraa_ashmawy@yahoo.com X admet-2022 11 49 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ PROPN admet-2022 11 50 a. a. NOUN admet-2022 11 51 z. z. PROPN admet-2022 11 52 g. g. PROPN admet-2022 11 53 al al PROPN admet-2022 11 54 ashmawy ashmawy PROPN admet-2022 11 55 et et PROPN admet-2022 11 56 al al PROPN admet-2022 11 57 . . PROPN admet-2022 11 58 admet admet PROPN admet-2022 11 59 & & CCONJ admet-2022 11 60 dmpk dmpk PROPN admet-2022 11 61 12(1 12(1 PROPN admet-2022 11 62 ) ) PUNCT admet-2022 11 63 ( ( PUNCT admet-2022 11 64 2024 2024 NUM admet-2022 11 65 ) ) PUNCT admet-2022 11 66 167 167 NUM admet-2022 11 67 - - SYM admet-2022 11 68 176 176 NUM admet-2022 11 69 168 168 NUM admet-2022 11 70 delivery delivery NOUN admet-2022 11 71 systems system NOUN admet-2022 11 72 , , PUNCT admet-2022 11 73 have have AUX admet-2022 11 74 been be AUX admet-2022 11 75 investigated investigate VERB admet-2022 11 76 [ [ PUNCT admet-2022 11 77 5 5 NUM admet-2022 11 78 ] ] PUNCT admet-2022 11 79 . . PUNCT admet-2022 12 1 both both PRON admet-2022 12 2 nanosuspensions nanosuspension NOUN admet-2022 12 3 and and CCONJ admet-2022 12 4 self self NOUN admet-2022 12 5 - - PUNCT admet-2022 12 6 nanoemulsifying nanoemulsifye VERB admet-2022 12 7 drug drug NOUN admet-2022 12 8 delivery delivery NOUN admet-2022 12 9 systems system NOUN admet-2022 12 10 ( ( PUNCT admet-2022 12 11 snedds snedds PROPN admet-2022 12 12 ) ) PUNCT admet-2022 12 13 are be AUX admet-2022 12 14 emerging emerge VERB admet-2022 12 15 nanotechnology nanotechnology NOUN admet-2022 12 16 techniques technique NOUN admet-2022 12 17 for for ADP admet-2022 12 18 the the DET admet-2022 12 19 enhancement enhancement NOUN admet-2022 12 20 of of ADP admet-2022 12 21 water water NOUN admet-2022 12 22 solubility solubility NOUN admet-2022 12 23 and and CCONJ admet-2022 12 24 bioavailability bioavailability NOUN admet-2022 12 25 of of ADP admet-2022 12 26 poorly poorly ADV admet-2022 12 27 water water NOUN admet-2022 12 28 - - PUNCT admet-2022 12 29 soluble soluble ADJ admet-2022 12 30 drugs drug NOUN admet-2022 12 31 with with ADP admet-2022 12 32 safe safe ADJ admet-2022 12 33 components component NOUN admet-2022 13 1 [ [ X admet-2022 13 2 6,7 6,7 NUM admet-2022 13 3 ] ] PUNCT admet-2022 13 4 . . PUNCT admet-2022 14 1 nanosuspensions nanosuspension NOUN admet-2022 14 2 are be AUX admet-2022 14 3 submicron submicron NOUN admet-2022 14 4 colloidal colloidal NOUN admet-2022 14 5 dispersions dispersion NOUN admet-2022 14 6 of of ADP admet-2022 14 7 drugs drug NOUN admet-2022 14 8 stabilized stabilize VERB admet-2022 14 9 by by ADP admet-2022 14 10 surfactants surfactant NOUN admet-2022 14 11 [ [ X admet-2022 14 12 7 7 NUM admet-2022 14 13 ] ] PUNCT admet-2022 14 14 . . PUNCT admet-2022 15 1 the the DET admet-2022 15 2 drug drug NOUN admet-2022 15 3 powder powder NOUN admet-2022 15 4 is be AUX admet-2022 15 5 transferred transfer VERB admet-2022 15 6 to to ADP admet-2022 15 7 drug drug NOUN admet-2022 15 8 nanoparticles nanoparticle NOUN admet-2022 15 9 using use VERB admet-2022 15 10 bottom bottom NOUN admet-2022 15 11 - - PUNCT admet-2022 15 12 up up NOUN admet-2022 15 13 and and CCONJ admet-2022 15 14 top top ADJ admet-2022 15 15 - - PUNCT admet-2022 15 16 down down ADP admet-2022 15 17 technologies technology NOUN admet-2022 15 18 [ [ X admet-2022 15 19 8 8 NUM admet-2022 15 20 ] ] PUNCT admet-2022 15 21 . . PUNCT admet-2022 16 1 nanosuspension nanosuspension NOUN admet-2022 16 2 emerged emerge VERB admet-2022 16 3 as as ADP admet-2022 16 4 a a DET admet-2022 16 5 solution solution NOUN admet-2022 16 6 to to PART admet-2022 16 7 deliver deliver VERB admet-2022 16 8 hydrophobic hydrophobic NOUN admet-2022 16 9 drugs drug NOUN admet-2022 16 10 . . PUNCT admet-2022 17 1 scaling scale VERB admet-2022 17 2 down down ADP admet-2022 17 3 nanoparticles nanoparticle NOUN admet-2022 17 4 increases increase VERB admet-2022 17 5 surface surface NOUN admet-2022 17 6 area area NOUN admet-2022 17 7 and and CCONJ admet-2022 17 8 enhances enhance VERB admet-2022 17 9 drug drug NOUN admet-2022 17 10 aqueous aqueous ADJ admet-2022 17 11 solubility solubility NOUN admet-2022 17 12 and and CCONJ admet-2022 17 13 bioavailability bioavailability NOUN admet-2022 17 14 [ [ X admet-2022 17 15 8,9 8,9 NUM admet-2022 17 16 ] ] PUNCT admet-2022 17 17 . . PUNCT admet-2022 18 1 the the DET admet-2022 18 2 main main ADJ admet-2022 18 3 components component NOUN admet-2022 18 4 of of ADP admet-2022 18 5 nanosuspensions nanosuspension NOUN admet-2022 18 6 are be AUX admet-2022 18 7 stabilizers stabilizer NOUN admet-2022 18 8 , , PUNCT admet-2022 18 9 organic organic ADJ admet-2022 18 10 solvents solvent NOUN admet-2022 18 11 , , PUNCT admet-2022 18 12 surfactants surfactant NOUN admet-2022 18 13 , , PUNCT admet-2022 18 14 co co NOUN admet-2022 18 15 - - NOUN admet-2022 18 16 surfactants surfactant NOUN admet-2022 18 17 and and CCONJ admet-2022 18 18 cryoprotectants cryoprotectant NOUN admet-2022 19 1 [ [ X admet-2022 19 2 10 10 NUM admet-2022 19 3 ] ] PUNCT admet-2022 19 4 . . PUNCT admet-2022 20 1 snedds snedd NOUN admet-2022 20 2 are be AUX admet-2022 20 3 anhydrous anhydrous ADJ admet-2022 20 4 mixtures mixture NOUN admet-2022 20 5 of of ADP admet-2022 20 6 oil oil NOUN admet-2022 20 7 , , PUNCT admet-2022 20 8 surfactant surfactant NOUN admet-2022 20 9 and and CCONJ admet-2022 20 10 co co NOUN admet-2022 20 11 - - NOUN admet-2022 20 12 surfactant surfactant ADJ admet-2022 20 13 in in ADP admet-2022 20 14 which which PRON admet-2022 20 15 the the DET admet-2022 20 16 drug drug NOUN admet-2022 20 17 is be AUX admet-2022 20 18 dissolved dissolve VERB admet-2022 20 19 . . PUNCT admet-2022 21 1 according accord VERB admet-2022 21 2 to to ADP admet-2022 21 3 their their PRON admet-2022 21 4 capacity capacity NOUN admet-2022 21 5 to to PART admet-2022 21 6 spontaneously spontaneously ADV admet-2022 21 7 generate generate VERB admet-2022 21 8 nanoemulsion nanoemulsion NOUN admet-2022 21 9 in in ADP admet-2022 21 10 the the DET admet-2022 21 11 gastrointestinal gastrointestinal ADJ admet-2022 21 12 environment environment NOUN admet-2022 21 13 following follow VERB admet-2022 21 14 oral oral ADJ admet-2022 21 15 administration administration NOUN admet-2022 21 16 , , PUNCT admet-2022 21 17 suitable suitable ADJ admet-2022 21 18 excipients excipient NOUN admet-2022 21 19 for for ADP admet-2022 21 20 snedds snedd NOUN admet-2022 21 21 , , PUNCT admet-2022 21 22 such such ADJ admet-2022 21 23 as as ADP admet-2022 21 24 oil oil NOUN admet-2022 21 25 , , PUNCT admet-2022 21 26 surfactant surfactant NOUN admet-2022 21 27 , , PUNCT admet-2022 21 28 and and CCONJ admet-2022 21 29 co co NOUN admet-2022 21 30 - - NOUN admet-2022 21 31 surfactant surfactant ADJ admet-2022 21 32 , , PUNCT admet-2022 21 33 are be AUX admet-2022 21 34 chosen choose VERB admet-2022 21 35 [ [ PUNCT admet-2022 21 36 11,12 11,12 NUM admet-2022 21 37 ] ] PUNCT admet-2022 21 38 . . PUNCT admet-2022 22 1 additionally additionally ADV admet-2022 22 2 , , PUNCT admet-2022 22 3 in in ADP admet-2022 22 4 situ situ NOUN admet-2022 22 5 solubilized solubilize VERB admet-2022 22 6 drugs drug NOUN admet-2022 22 7 that that PRON admet-2022 22 8 develop develop VERB admet-2022 22 9 in in ADP admet-2022 22 10 the the DET admet-2022 22 11 gastrointestinal gastrointestinal ADJ admet-2022 22 12 tract tract NOUN admet-2022 22 13 ( ( PUNCT admet-2022 22 14 git git NOUN admet-2022 22 15 ) ) PUNCT admet-2022 22 16 lumen luman NOUN admet-2022 22 17 can can AUX admet-2022 22 18 be be AUX admet-2022 22 19 ultimately ultimately ADV admet-2022 22 20 absorbed absorb VERB admet-2022 22 21 via via ADP admet-2022 22 22 the the DET admet-2022 22 23 lymphatic lymphatic ADJ admet-2022 22 24 system system NOUN admet-2022 22 25 without without ADP admet-2022 22 26 going go VERB admet-2022 22 27 through through ADP admet-2022 22 28 the the DET admet-2022 22 29 liver liver NOUN admet-2022 22 30 's 's PART admet-2022 22 31 first first ADJ admet-2022 22 32 - - PUNCT admet-2022 22 33 pass pass VERB admet-2022 22 34 metabolism metabolism NOUN admet-2022 22 35 [ [ X admet-2022 22 36 13 13 NUM admet-2022 22 37 ] ] PUNCT admet-2022 22 38 . . PUNCT admet-2022 23 1 they they PRON admet-2022 23 2 are be AUX admet-2022 23 3 kept keep VERB admet-2022 23 4 anhydrous anhydrous ADJ admet-2022 23 5 until until ADP admet-2022 23 6 diluted dilute VERB admet-2022 23 7 with with ADP admet-2022 23 8 gastrointestinal gastrointestinal ADJ admet-2022 23 9 tract tract NOUN admet-2022 23 10 fluids fluid NOUN admet-2022 23 11 and and CCONJ admet-2022 23 12 turned turn VERB admet-2022 23 13 into into ADP admet-2022 23 14 oil oil NOUN admet-2022 23 15 in in ADP admet-2022 23 16 water water NOUN admet-2022 23 17 emulsion emulsion NOUN admet-2022 23 18 of of ADP admet-2022 23 19 very very ADV admet-2022 23 20 small small ADJ admet-2022 23 21 size size NOUN admet-2022 23 22 , , PUNCT admet-2022 23 23 nearly nearly ADV admet-2022 23 24 200 200 NUM admet-2022 23 25 nm nm NOUN admet-2022 23 26 or or CCONJ admet-2022 23 27 less less ADJ admet-2022 23 28 [ [ X admet-2022 23 29 6,14 6,14 NUM admet-2022 23 30 ] ] PUNCT admet-2022 23 31 . . PUNCT admet-2022 24 1 snedds snedd NOUN admet-2022 24 2 become become VERB admet-2022 24 3 preferable preferable ADJ admet-2022 24 4 to to ADP admet-2022 24 5 nanoemulsions nanoemulsion NOUN admet-2022 24 6 for for ADP admet-2022 24 7 many many ADJ admet-2022 24 8 reasons reason NOUN admet-2022 24 9 , , PUNCT admet-2022 24 10 including include VERB admet-2022 24 11 that that SCONJ admet-2022 24 12 snedds snedd NOUN admet-2022 24 13 give give VERB admet-2022 24 14 rise rise NOUN admet-2022 24 15 to to ADP admet-2022 24 16 more more ADV admet-2022 24 17 stable stable ADJ admet-2022 24 18 formulations formulation NOUN admet-2022 24 19 that that PRON admet-2022 24 20 can can AUX admet-2022 24 21 be be AUX admet-2022 24 22 stored store VERB admet-2022 24 23 longer long ADV admet-2022 24 24 . . PUNCT admet-2022 25 1 also also ADV admet-2022 25 2 , , PUNCT admet-2022 25 3 it it PRON admet-2022 25 4 can can AUX admet-2022 25 5 be be AUX admet-2022 25 6 easily easily ADV admet-2022 25 7 filled fill VERB admet-2022 25 8 into into ADP admet-2022 25 9 capsules capsule NOUN admet-2022 25 10 [ [ X admet-2022 25 11 6 6 NUM admet-2022 25 12 ] ] PUNCT admet-2022 25 13 . . PUNCT admet-2022 26 1 both both DET admet-2022 26 2 nanosuspensions nanosuspension NOUN admet-2022 26 3 and and CCONJ admet-2022 26 4 nanoemulsions nanoemulsion NOUN admet-2022 26 5 are be AUX admet-2022 26 6 able able ADJ admet-2022 26 7 to to PART admet-2022 26 8 increase increase VERB admet-2022 26 9 water water NOUN admet-2022 26 10 solubility solubility NOUN admet-2022 26 11 and and CCONJ admet-2022 26 12 , , PUNCT admet-2022 26 13 hence hence ADV admet-2022 26 14 , , PUNCT admet-2022 26 15 bioavailability bioavailability NOUN admet-2022 26 16 of of ADP admet-2022 26 17 poorly poorly ADV admet-2022 26 18 water water NOUN admet-2022 26 19 - - PUNCT admet-2022 26 20 soluble soluble ADJ admet-2022 26 21 drugs drug NOUN admet-2022 26 22 . . PUNCT admet-2022 27 1 doxazosin doxazosin VERB admet-2022 27 2 mesylate mesylate NOUN admet-2022 27 3 ( ( PUNCT admet-2022 27 4 dox dox NOUN admet-2022 27 5 ) ) PUNCT admet-2022 27 6 , , PUNCT admet-2022 27 7 α1 α1 ADJ admet-2022 27 8 - - PUNCT admet-2022 27 9 adrenergic adrenergic ADJ admet-2022 27 10 receptor receptor NOUN admet-2022 27 11 blocker blocker NOUN admet-2022 27 12 , , PUNCT admet-2022 27 13 is be AUX admet-2022 27 14 an an DET admet-2022 27 15 antihypertensive antihypertensive ADJ admet-2022 27 16 drug drug NOUN admet-2022 27 17 that that PRON admet-2022 27 18 suffers suffer VERB admet-2022 27 19 from from ADP admet-2022 27 20 low low ADJ admet-2022 27 21 bioavailability bioavailability NOUN admet-2022 27 22 ( ( PUNCT admet-2022 27 23 65 65 NUM admet-2022 27 24 % % NOUN admet-2022 27 25 ) ) PUNCT admet-2022 27 26 due due ADP admet-2022 27 27 to to ADP admet-2022 27 28 poor poor ADJ admet-2022 27 29 aqueous aqueous ADJ admet-2022 27 30 solubility solubility NOUN admet-2022 27 31 and and CCONJ admet-2022 27 32 extensive extensive ADJ admet-2022 27 33 first first ADJ admet-2022 27 34 - - PUNCT admet-2022 27 35 pass pass VERB admet-2022 27 36 metabolism metabolism NOUN admet-2022 27 37 [ [ X admet-2022 27 38 15 15 NUM admet-2022 27 39 ] ] PUNCT admet-2022 27 40 . . PUNCT admet-2022 28 1 the the DET admet-2022 28 2 immediate immediate ADJ admet-2022 28 3 - - PUNCT admet-2022 28 4 release release NOUN admet-2022 28 5 and and CCONJ admet-2022 28 6 the the DET admet-2022 28 7 extended extend VERB admet-2022 28 8 - - PUNCT admet-2022 28 9 release release NOUN admet-2022 28 10 forms form NOUN admet-2022 28 11 of of ADP admet-2022 28 12 doxazosin doxazosin NOUN admet-2022 28 13 are be AUX admet-2022 28 14 used use VERB admet-2022 28 15 to to PART admet-2022 28 16 treat treat VERB admet-2022 28 17 benign benign ADJ admet-2022 28 18 prostatic prostatic ADJ admet-2022 28 19 hyperplasia hyperplasia NOUN admet-2022 28 20 ( ( PUNCT admet-2022 28 21 bph bph NOUN admet-2022 28 22 ) ) PUNCT admet-2022 28 23 . . PUNCT admet-2022 29 1 the the DET admet-2022 29 2 immediate immediate ADJ admet-2022 29 3 - - PUNCT admet-2022 29 4 release release NOUN admet-2022 29 5 tablets tablet NOUN admet-2022 29 6 are be AUX admet-2022 29 7 also also ADV admet-2022 29 8 used use VERB admet-2022 29 9 to to PART admet-2022 29 10 treat treat VERB admet-2022 29 11 high high ADJ admet-2022 29 12 blood blood NOUN admet-2022 29 13 pressure pressure NOUN admet-2022 29 14 . . PUNCT admet-2022 30 1 doxazosin doxazosin PROPN admet-2022 30 2 works work VERB admet-2022 30 3 by by ADP admet-2022 30 4 blocking block VERB admet-2022 30 5 the the DET admet-2022 30 6 alpha-1a alpha-1a NOUN admet-2022 30 7 , , PUNCT admet-2022 30 8 alpha-1b alpha-1b PUNCT admet-2022 30 9 , , PUNCT admet-2022 30 10 and and CCONJ admet-2022 30 11 alpha-1d alpha-1d ADP admet-2022 30 12 subtypes subtype NOUN admet-2022 30 13 , , PUNCT admet-2022 30 14 which which PRON admet-2022 30 15 helps help VERB admet-2022 30 16 to to PART admet-2022 30 17 widen widen VERB admet-2022 30 18 blood blood NOUN admet-2022 30 19 vessels vessel NOUN admet-2022 30 20 and and CCONJ admet-2022 30 21 relax relax VERB admet-2022 30 22 muscles muscle NOUN admet-2022 30 23 in in ADP admet-2022 30 24 the the DET admet-2022 30 25 prostate prostate NOUN admet-2022 30 26 and and CCONJ admet-2022 30 27 bladder bladder NOUN admet-2022 30 28 . . PUNCT admet-2022 31 1 the the DET admet-2022 31 2 immediate immediate ADJ admet-2022 31 3 - - PUNCT admet-2022 31 4 release release NOUN admet-2022 31 5 formulation formulation NOUN admet-2022 31 6 can can AUX admet-2022 31 7 be be AUX admet-2022 31 8 a a DET admet-2022 31 9 second second ADJ admet-2022 31 10 - - PUNCT admet-2022 31 11 line line NOUN admet-2022 31 12 agent agent NOUN admet-2022 31 13 for for ADP admet-2022 31 14 managing manage VERB admet-2022 31 15 hypertension hypertension NOUN admet-2022 31 16 in in ADP admet-2022 31 17 patients patient NOUN admet-2022 31 18 with with ADP admet-2022 31 19 concomitant concomitant ADJ admet-2022 31 20 bph bph NOUN admet-2022 31 21 [ [ X admet-2022 31 22 16 16 NUM admet-2022 31 23 ] ] PUNCT admet-2022 31 24 . . PUNCT admet-2022 32 1 the the DET admet-2022 32 2 aim aim NOUN admet-2022 32 3 of of ADP admet-2022 32 4 the the DET admet-2022 32 5 study study NOUN admet-2022 32 6 is be AUX admet-2022 32 7 to to PART admet-2022 32 8 compare compare VERB admet-2022 32 9 the the DET admet-2022 32 10 efficiency efficiency NOUN admet-2022 32 11 of of ADP admet-2022 32 12 different different ADJ admet-2022 32 13 formulations formulation NOUN admet-2022 32 14 of of ADP admet-2022 32 15 dox dox NOUN admet-2022 32 16 in in ADP admet-2022 32 17 the the DET admet-2022 32 18 immediate immediate ADJ admet-2022 32 19 release release NOUN admet-2022 32 20 form form NOUN admet-2022 32 21 , , PUNCT admet-2022 32 22 i.e. i.e. X admet-2022 32 23 , , PUNCT admet-2022 32 24 nanosuspension nanosuspension NOUN admet-2022 32 25 , , PUNCT admet-2022 32 26 liquid liquid ADJ admet-2022 32 27 snedds snedd NOUN admet-2022 32 28 and and CCONJ admet-2022 32 29 solid solid ADJ admet-2022 32 30 snedds snedd NOUN admet-2022 32 31 , , PUNCT admet-2022 32 32 in in ADP admet-2022 32 33 improving improve VERB admet-2022 32 34 the the DET admet-2022 32 35 release release NOUN admet-2022 32 36 properties property NOUN admet-2022 32 37 of of ADP admet-2022 32 38 dox dox NOUN admet-2022 32 39 as as ADV admet-2022 32 40 well well ADV admet-2022 32 41 as as ADP admet-2022 32 42 its its PRON admet-2022 32 43 antihypertensive antihypertensive ADJ admet-2022 32 44 effect effect NOUN admet-2022 32 45 . . PUNCT admet-2022 33 1 experimental experimental ADJ admet-2022 33 2 materials material NOUN admet-2022 33 3 doxazosin doxazosin VERB admet-2022 33 4 mesylate mesylate NOUN admet-2022 33 5 , , PUNCT admet-2022 33 6 peg peg NOUN admet-2022 33 7 400 400 NUM admet-2022 33 8 , , PUNCT admet-2022 33 9 avicel avicel VERB admet-2022 33 10 101 101 NUM admet-2022 33 11 , , PUNCT admet-2022 33 12 aerosil aerosil NOUN admet-2022 33 13 200 200 NUM admet-2022 33 14 , , PUNCT admet-2022 33 15 polyvinylpyrrolidone polyvinylpyrrolidone NOUN admet-2022 33 16 k-30 k-30 NOUN admet-2022 33 17 ( ( PUNCT admet-2022 33 18 pvp pvp VERB admet-2022 33 19 k k PROPN admet-2022 33 20 30 30 NUM admet-2022 33 21 ) ) PUNCT admet-2022 33 22 , , PUNCT admet-2022 33 23 poloxamer poloxamer NOUN admet-2022 33 24 407 407 NUM admet-2022 33 25 , , PUNCT admet-2022 33 26 microcrystalline microcrystalline NOUN admet-2022 33 27 cellulose cellulose NOUN admet-2022 33 28 , , PUNCT admet-2022 33 29 crospovidone crospovidone NOUN admet-2022 33 30 , , PUNCT admet-2022 33 31 ac ac PROPN admet-2022 33 32 - - PUNCT admet-2022 33 33 di di NOUN admet-2022 33 34 - - PUNCT admet-2022 33 35 sol sol NOUN admet-2022 33 36 , , PUNCT admet-2022 33 37 sodium sodium NOUN admet-2022 33 38 starch starch NOUN admet-2022 33 39 glycolate glycolate NOUN admet-2022 33 40 , , PUNCT admet-2022 33 41 sodium sodium NOUN admet-2022 33 42 saccharin saccharin NOUN admet-2022 33 43 , , PUNCT admet-2022 33 44 mint mint NOUN admet-2022 33 45 flavour flavour NOUN admet-2022 33 46 , , PUNCT admet-2022 33 47 magnesium magnesium NOUN admet-2022 33 48 stearate stearate NOUN admet-2022 33 49 , , PUNCT admet-2022 33 50 talc talc NOUN admet-2022 33 51 powder powder NOUN admet-2022 33 52 and and CCONJ admet-2022 33 53 marketed market VERB admet-2022 33 54 tablet tablet NOUN admet-2022 33 55 dosin dosin NOUN admet-2022 33 56 ® ® NOUN admet-2022 33 57 were be AUX admet-2022 33 58 kindly kindly ADV admet-2022 33 59 supplied supply VERB admet-2022 33 60 from from ADP admet-2022 33 61 epico epico PROPN admet-2022 33 62 co. co. PROPN admet-2022 33 63 , , PUNCT admet-2022 33 64 egypt egypt PROPN admet-2022 33 65 . . PUNCT admet-2022 34 1 10 10 NUM admet-2022 34 2 % % NOUN admet-2022 34 3 glucose glucose NOUN admet-2022 34 4 solution solution NOUN admet-2022 34 5 and and CCONJ admet-2022 34 6 oleic oleic VERB admet-2022 34 7 acid acid PROPN admet-2022 34 8 were be AUX admet-2022 34 9 purchased purchase VERB admet-2022 34 10 from from ADP admet-2022 34 11 sigma sigma PROPN admet-2022 34 12 chemical chemical PROPN admet-2022 34 13 co. co. PROPN admet-2022 34 14 , , PUNCT admet-2022 34 15 st st PROPN admet-2022 34 16 . . PROPN admet-2022 34 17 louis louis PROPN admet-2022 34 18 , , PUNCT admet-2022 34 19 mo mo PROPN admet-2022 34 20 , , PUNCT admet-2022 34 21 usa usa PROPN admet-2022 34 22 . . PROPN admet-2022 35 1 all all DET admet-2022 35 2 the the DET admet-2022 35 3 chemicals chemical NOUN admet-2022 35 4 used use VERB admet-2022 35 5 were be AUX admet-2022 35 6 at at ADP admet-2022 35 7 analytical analytical ADJ admet-2022 35 8 grade grade NOUN admet-2022 35 9 . . PUNCT admet-2022 36 1 preparation preparation NOUN admet-2022 36 2 of of ADP admet-2022 36 3 dox dox NOUN admet-2022 36 4 nanosuspension nanosuspension NOUN admet-2022 36 5 dox dox NOUN admet-2022 36 6 nanosuspension nanosuspension NOUN admet-2022 36 7 formula formula NOUN admet-2022 36 8 ( ( PUNCT admet-2022 36 9 f f X admet-2022 36 10 ) ) PUNCT admet-2022 36 11 was be AUX admet-2022 36 12 prepared prepare VERB admet-2022 36 13 via via ADP admet-2022 36 14 emulsion emulsion NOUN admet-2022 36 15 solvent solvent NOUN admet-2022 36 16 diffusion diffusion NOUN admet-2022 36 17 technique technique NOUN admet-2022 36 18 using use VERB admet-2022 36 19 533 533 NUM admet-2022 36 20 mg mg NOUN admet-2022 36 21 of of ADP admet-2022 36 22 pvp pvp PROPN admet-2022 36 23 k-30 k-30 PROPN admet-2022 36 24 , , PUNCT admet-2022 36 25 133 133 NUM admet-2022 36 26 mg mg NOUN admet-2022 36 27 of of ADP admet-2022 36 28 poloxamer-407 poloxamer-407 NOUN admet-2022 36 29 and and CCONJ admet-2022 36 30 133 133 NUM admet-2022 36 31 mg mg NOUN admet-2022 36 32 of of ADP admet-2022 36 33 sls sls PROPN admet-2022 36 34 as as ADP admet-2022 36 35 stabilizers stabilizer NOUN admet-2022 36 36 and and CCONJ admet-2022 36 37 methanol methanol NOUN admet-2022 36 38 ( ( PUNCT admet-2022 36 39 100 100 NUM admet-2022 36 40 ml ml NOUN admet-2022 36 41 ) ) PUNCT admet-2022 36 42 as as ADP admet-2022 36 43 a a DET admet-2022 36 44 solvent solvent NOUN admet-2022 36 45 to to PART admet-2022 36 46 form form VERB admet-2022 36 47 a a DET admet-2022 36 48 solution solution NOUN admet-2022 36 49 of of ADP admet-2022 36 50 dox dox NOUN admet-2022 36 51 ( ( PUNCT admet-2022 36 52 400 400 NUM admet-2022 36 53 mg mg NUM admet-2022 36 54 ) ) PUNCT admet-2022 36 55 . . PUNCT admet-2022 37 1 the the DET admet-2022 37 2 solution solution NOUN admet-2022 37 3 was be AUX admet-2022 37 4 homogenized homogenize VERB admet-2022 37 5 ( ( PUNCT admet-2022 37 6 ika ika PROPN admet-2022 37 7 t t PROPN admet-2022 37 8 25 25 NUM admet-2022 37 9 digital digital PROPN admet-2022 37 10 ultraturrax ultraturrax NOUN admet-2022 37 11 ) ) PUNCT admet-2022 37 12 at at ADP admet-2022 37 13 7400 7400 NUM admet-2022 37 14 rpm rpm NOUN admet-2022 37 15 for for ADP admet-2022 37 16 7 7 NUM admet-2022 37 17 min min NOUN admet-2022 37 18 , , PUNCT admet-2022 37 19 then then ADV admet-2022 37 20 accelerated accelerate VERB admet-2022 37 21 to to ADP admet-2022 37 22 24,000 24,000 NUM admet-2022 37 23 rpm rpm NOUN admet-2022 37 24 for for ADP admet-2022 37 25 6 6 NUM admet-2022 37 26 min min NOUN admet-2022 37 27 at at ADP admet-2022 37 28 room room NOUN admet-2022 37 29 temperature temperature NOUN admet-2022 37 30 . . PUNCT admet-2022 38 1 a a DET admet-2022 38 2 probe probe NOUN admet-2022 38 3 sonicator sonicator NOUN admet-2022 38 4 ( ( PUNCT admet-2022 38 5 model model NOUN admet-2022 38 6 ge ge PROPN admet-2022 38 7 50 50 NUM admet-2022 38 8 , , PUNCT admet-2022 38 9 scientific scientific ADJ admet-2022 38 10 engineering engineering PROPN admet-2022 38 11 inc inc PROPN admet-2022 38 12 . . PROPN admet-2022 38 13 , , PUNCT admet-2022 38 14 woodbridge woodbridge PROPN admet-2022 38 15 , , PUNCT admet-2022 38 16 virginia virginia PROPN admet-2022 38 17 , , PUNCT admet-2022 38 18 usa usa PROPN admet-2022 38 19 ) ) PUNCT admet-2022 38 20 was be AUX admet-2022 38 21 then then ADV admet-2022 38 22 used use VERB admet-2022 38 23 to to PART admet-2022 38 24 sonicate sonicate VERB admet-2022 38 25 the the DET admet-2022 38 26 formed form VERB admet-2022 38 27 suspension suspension NOUN admet-2022 38 28 . . PUNCT admet-2022 39 1 finally finally ADV admet-2022 39 2 , , PUNCT admet-2022 39 3 30 30 NUM admet-2022 39 4 ml ml NOUN admet-2022 39 5 of of ADP admet-2022 39 6 distilled distil VERB admet-2022 39 7 water water NOUN admet-2022 39 8 was be AUX admet-2022 39 9 added add VERB admet-2022 39 10 to to ADP admet-2022 39 11 the the DET admet-2022 39 12 suspension suspension NOUN admet-2022 39 13 and and CCONJ admet-2022 39 14 stirred stir VERB admet-2022 39 15 using use VERB admet-2022 39 16 a a DET admet-2022 39 17 magnetic magnetic ADJ admet-2022 39 18 stirrer stirrer NOUN admet-2022 39 19 ( ( PUNCT admet-2022 39 20 type type PROPN admet-2022 39 21 mm5 mm5 PROPN admet-2022 39 22 , , PUNCT admet-2022 39 23 poland poland PROPN admet-2022 39 24 ) ) PUNCT admet-2022 39 25 for for ADP admet-2022 39 26 1 1 NUM admet-2022 39 27 h. h. PROPN admet-2022 39 28 admet admet PROPN admet-2022 39 29 & & CCONJ admet-2022 39 30 dmpk dmpk PROPN admet-2022 39 31 12(1 12(1 PROPN admet-2022 39 32 ) ) PUNCT admet-2022 39 33 ( ( PUNCT admet-2022 39 34 2024 2024 NUM admet-2022 39 35 ) ) PUNCT admet-2022 39 36 167 167 NUM admet-2022 39 37 - - SYM admet-2022 39 38 176 176 NUM admet-2022 39 39 nanosuspension nanosuspension NOUN admet-2022 39 40 versus versus ADP admet-2022 39 41 self self NOUN admet-2022 39 42 - - PUNCT admet-2022 39 43 nanoemulsifying nanoemulsifye VERB admet-2022 39 44 drug drug NOUN admet-2022 39 45 delivery delivery NOUN admet-2022 39 46 doi doi NOUN admet-2022 39 47 : : PUNCT admet-2022 39 48 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 39 49 169 169 NUM admet-2022 39 50 nanosuspension nanosuspension NOUN admet-2022 39 51 formed form VERB admet-2022 39 52 was be AUX admet-2022 39 53 lyophilized lyophilize VERB admet-2022 39 54 ( ( PUNCT admet-2022 39 55 heto heto NOUN admet-2022 39 56 power power NOUN admet-2022 39 57 dry dry ADJ admet-2022 39 58 ll1500 ll1500 NOUN admet-2022 39 59 - - PUNCT admet-2022 39 60 thermo thermo NOUN admet-2022 39 61 electron electron NOUN admet-2022 39 62 corporation corporation NOUN admet-2022 39 63 , , PUNCT admet-2022 39 64 usa usa PROPN admet-2022 39 65 ) ) PUNCT admet-2022 39 66 for for ADP admet-2022 39 67 48 48 NUM admet-2022 39 68 h h NOUN admet-2022 39 69 , , PUNCT admet-2022 39 70 at at ADP admet-2022 39 71 -75 -75 PROPN admet-2022 39 72 ° ° PROPN admet-2022 39 73 c c NOUN admet-2022 39 74 at at ADP admet-2022 39 75 an an DET admet-2022 39 76 increasing increase VERB admet-2022 39 77 rate rate NOUN admet-2022 39 78 of of ADP admet-2022 39 79 5 5 NUM admet-2022 39 80 ° ° NOUN admet-2022 39 81 c c NOUN admet-2022 39 82 h-1 h-1 NOUN admet-2022 40 1 [ [ X admet-2022 40 2 8 8 NUM admet-2022 40 3 ] ] PUNCT admet-2022 40 4 , , PUNCT admet-2022 40 5 to to PART admet-2022 40 6 attain attain VERB admet-2022 40 7 a a DET admet-2022 40 8 dry dry ADJ admet-2022 40 9 stable stable ADJ admet-2022 40 10 form form NOUN admet-2022 40 11 of of ADP admet-2022 40 12 nanosuspension nanosuspension NOUN admet-2022 40 13 ( ( PUNCT admet-2022 40 14 f f NOUN admet-2022 40 15 ) ) PUNCT admet-2022 40 16 . . PUNCT admet-2022 41 1 glucose glucose NOUN admet-2022 41 2 solution solution NOUN admet-2022 41 3 ( ( PUNCT admet-2022 41 4 10 10 NUM admet-2022 41 5 % % NOUN admet-2022 41 6 ) ) PUNCT admet-2022 41 7 was be AUX admet-2022 41 8 used use VERB admet-2022 41 9 as as ADP admet-2022 41 10 a a DET admet-2022 41 11 cryoprotectant cryoprotectant NOUN admet-2022 41 12 . . PUNCT admet-2022 42 1 preparation preparation NOUN admet-2022 42 2 of of ADP admet-2022 42 3 snedds snedd NOUN admet-2022 42 4 according accord VERB admet-2022 42 5 to to ADP admet-2022 42 6 ali ali PROPN admet-2022 42 7 and and CCONJ admet-2022 42 8 hussein hussein PROPN admet-2022 42 9 , , PUNCT admet-2022 42 10 2017 2017 NUM admet-2022 43 1 [ [ X admet-2022 43 2 17 17 NUM admet-2022 43 3 ] ] PUNCT admet-2022 43 4 , , PUNCT admet-2022 43 5 the the DET admet-2022 43 6 liquid liquid ADJ admet-2022 43 7 formula formula NOUN admet-2022 43 8 of of ADP admet-2022 43 9 snedds snedds PROPN admet-2022 43 10 ( ( PUNCT admet-2022 43 11 l l NOUN admet-2022 43 12 ) ) PUNCT admet-2022 43 13 was be AUX admet-2022 43 14 prepared prepare VERB admet-2022 43 15 ( ( PUNCT admet-2022 43 16 10 10 NUM admet-2022 43 17 % % NOUN admet-2022 43 18 oleic oleic ADV admet-2022 43 19 acid acid NOUN admet-2022 43 20 , , PUNCT admet-2022 43 21 67.5 67.5 NUM admet-2022 43 22 % % NOUN admet-2022 43 23 tween tween NOUN admet-2022 43 24 80 80 NUM admet-2022 43 25 , , PUNCT admet-2022 43 26 11.25 11.25 NUM admet-2022 43 27 % % NOUN admet-2022 43 28 peg peg NOUN admet-2022 43 29 400 400 NUM admet-2022 43 30 and and CCONJ admet-2022 43 31 11.25 11.25 NUM admet-2022 43 32 % % NOUN admet-2022 43 33 ethanol ethanol NOUN admet-2022 43 34 ) ) PUNCT admet-2022 43 35 in in ADP admet-2022 43 36 the the DET admet-2022 43 37 ratio ratio NOUN admet-2022 43 38 ( ( PUNCT admet-2022 43 39 oil oil NOUN admet-2022 43 40 : : PUNCT admet-2022 43 41 smix smix NOUN admet-2022 43 42 ( ( PUNCT admet-2022 43 43 surfactant surfactant NOUN admet-2022 43 44 : : PUNCT admet-2022 43 45 co co ADJ admet-2022 43 46 - - ADJ admet-2022 43 47 surfactant surfactant ADJ admet-2022 43 48 mixture mixture NOUN admet-2022 43 49 ) ) PUNCT admet-2022 43 50 of of ADP admet-2022 43 51 1:9 1:9 NUM admet-2022 43 52 ) ) PUNCT admet-2022 43 53 , , PUNCT admet-2022 43 54 the the DET admet-2022 43 55 mixture mixture NOUN admet-2022 43 56 contains contain VERB admet-2022 43 57 400 400 NUM admet-2022 43 58 mg mg PROPN admet-2022 43 59 dox dox NOUN admet-2022 43 60 . . PUNCT admet-2022 44 1 preparation preparation NOUN admet-2022 44 2 of of ADP admet-2022 44 3 dox dox NOUN admet-2022 44 4 solid solid ADJ admet-2022 44 5 snedds snedd NOUN admet-2022 44 6 0.6 0.6 NUM admet-2022 44 7 g g NOUN admet-2022 44 8 of of ADP admet-2022 44 9 freshly freshly ADV admet-2022 44 10 prepared prepare VERB admet-2022 44 11 liquid liquid ADJ admet-2022 44 12 sneeds sneed NOUN admet-2022 44 13 of of ADP admet-2022 44 14 dox dox NOUN admet-2022 44 15 ( ( PUNCT admet-2022 44 16 l l NOUN admet-2022 44 17 ) ) PUNCT admet-2022 44 18 , , PUNCT admet-2022 44 19 equivalent equivalent ADJ admet-2022 44 20 to to ADP admet-2022 44 21 400 400 NUM admet-2022 44 22 mg mg NOUN admet-2022 44 23 of of ADP admet-2022 44 24 dox dox NOUN admet-2022 44 25 was be AUX admet-2022 44 26 dried dry VERB admet-2022 44 27 to to ADP admet-2022 44 28 the the DET admet-2022 44 29 solid solid ADJ admet-2022 44 30 form form NOUN admet-2022 44 31 using use VERB admet-2022 44 32 a a DET admet-2022 44 33 mixture mixture NOUN admet-2022 44 34 of of ADP admet-2022 44 35 avicel avicel PROPN admet-2022 44 36 101 101 NUM admet-2022 44 37 and and CCONJ admet-2022 44 38 aerosil aerosil NOUN admet-2022 44 39 200 200 NUM admet-2022 44 40 ( ( PUNCT admet-2022 44 41 600 600 NUM admet-2022 44 42 mg mg NOUN admet-2022 44 43 and and CCONJ admet-2022 44 44 15 15 NUM admet-2022 44 45 mg mg PROPN admet-2022 44 46 , , PUNCT admet-2022 44 47 respectively respectively ADV admet-2022 44 48 ) ) PUNCT admet-2022 44 49 in in ADP admet-2022 44 50 a a DET admet-2022 44 51 ratio ratio NOUN admet-2022 44 52 of of ADP admet-2022 44 53 ( ( PUNCT admet-2022 44 54 40:1 40:1 NUM admet-2022 44 55 w w PROPN admet-2022 44 56 / / SYM admet-2022 44 57 w w PROPN admet-2022 44 58 ) ) PUNCT admet-2022 44 59 , , PUNCT admet-2022 44 60 their their PRON admet-2022 44 61 mixing mixing NOUN admet-2022 44 62 was be AUX admet-2022 44 63 done do VERB admet-2022 44 64 in in ADP admet-2022 44 65 a a DET admet-2022 44 66 porcelain porcelain NOUN admet-2022 44 67 mortar mortar NOUN admet-2022 44 68 . . PUNCT admet-2022 45 1 characterization characterization NOUN admet-2022 45 2 of of ADP admet-2022 45 3 dox dox NOUN admet-2022 45 4 nanosuspension nanosuspension NOUN admet-2022 45 5 and and CCONJ admet-2022 45 6 snedds snedd VERB admet-2022 45 7 drug drug NOUN admet-2022 45 8 content content PROPN admet-2022 45 9 analysis analysis NOUN admet-2022 45 10 of of ADP admet-2022 45 11 nanosuspension nanosuspension NOUN admet-2022 45 12 10 10 NUM admet-2022 45 13 ml ml NOUN admet-2022 45 14 of of ADP admet-2022 45 15 all all PRON admet-2022 45 16 freshly freshly ADV admet-2022 45 17 made make VERB admet-2022 45 18 nanosuspension nanosuspension NOUN admet-2022 45 19 were be AUX admet-2022 45 20 centrifugated centrifugate VERB admet-2022 45 21 at at ADP admet-2022 45 22 10,000 10,000 NUM admet-2022 45 23 rpm rpm NOUN admet-2022 45 24 at at ADP admet-2022 45 25 25 25 NUM admet-2022 45 26 ° ° NOUN admet-2022 45 27 c c NOUN admet-2022 45 28 for for ADP admet-2022 45 29 10 10 NUM admet-2022 45 30 min min NOUN admet-2022 45 31 using use VERB admet-2022 45 32 a a DET admet-2022 45 33 centrifuge centrifuge NOUN admet-2022 45 34 ( ( PUNCT admet-2022 45 35 model model NOUN admet-2022 45 36 z z PROPN admet-2022 45 37 300 300 NUM admet-2022 45 38 k k NOUN admet-2022 45 39 , , PUNCT admet-2022 45 40 hermle hermle NOUN admet-2022 45 41 labortechnik labortechnik VERB admet-2022 45 42 gmbh gmbh PROPN admet-2022 45 43 , , PUNCT admet-2022 45 44 wehingen wehingen PROPN admet-2022 45 45 , , PUNCT admet-2022 45 46 germany germany PROPN admet-2022 45 47 ) ) PUNCT admet-2022 45 48 . . PUNCT admet-2022 46 1 in in ADP admet-2022 46 2 order order NOUN admet-2022 46 3 to to PART admet-2022 46 4 determine determine VERB admet-2022 46 5 the the DET admet-2022 46 6 free free ADJ admet-2022 46 7 drug drug NOUN admet-2022 46 8 , , PUNCT admet-2022 46 9 the the DET admet-2022 46 10 supernatant supernatant NOUN admet-2022 46 11 was be AUX admet-2022 46 12 then then ADV admet-2022 46 13 analysed analyse VERB admet-2022 46 14 at at ADP admet-2022 46 15 λmax λmax NOUN admet-2022 46 16 266 266 NUM admet-2022 46 17 nm nm NOUN admet-2022 46 18 by by ADP admet-2022 46 19 uv uv NOUN admet-2022 46 20 - - PUNCT admet-2022 46 21 vis vis X admet-2022 46 22 spectrophotometer spectrophotometer X admet-2022 46 23 ( ( PUNCT admet-2022 46 24 genesys genesys PROPN admet-2022 46 25 10s 10 NOUN admet-2022 46 26 uv uv NOUN admet-2022 46 27 - - PUNCT admet-2022 46 28 vis vis X admet-2022 46 29 , , PUNCT admet-2022 46 30 thermo thermo NOUN admet-2022 46 31 spectronic spectronic ADJ admet-2022 46 32 , , PUNCT admet-2022 46 33 waltham waltham PROPN admet-2022 46 34 , , PUNCT admet-2022 46 35 ma ma PROPN admet-2022 46 36 , , PUNCT admet-2022 46 37 usa usa PROPN admet-2022 46 38 ) ) PUNCT admet-2022 46 39 . . PUNCT admet-2022 47 1 drug drug NOUN admet-2022 47 2 content content NOUN admet-2022 47 3 was be AUX admet-2022 47 4 calculated calculate VERB admet-2022 47 5 using use VERB admet-2022 47 6 equation equation NOUN admet-2022 47 7 1 1 NUM admet-2022 48 1 [ [ X admet-2022 48 2 18 18 NUM admet-2022 48 3 ] ] PUNCT admet-2022 48 4 . . PUNCT admet-2022 49 1 initial initial ADJ admet-2022 49 2     SPACE admet-2022 49 3 drug drug NOUN admet-2022 49 4 free free ADJ admet-2022 49 5     SPACE admet-2022 49 6 drug drug NOUN admet-2022 49 7 initial initial ADJ admet-2022 49 8     SPACE admet-2022 49 9 drug drug NOUN admet-2022 49 10 drug drug NOUN admet-2022 49 11     SPACE admet-2022 49 12 content content NOUN admet-2022 49 13     SPACE admet-2022 49 14 100 100 NUM admet-2022 49 15 w w PROPN admet-2022 49 16 w w PROPN admet-2022 49 17 w w PROPN admet-2022 49 18   PROPN admet-2022 49 19 − − NOUN admet-2022 49 20 = = SYM admet-2022 49 21   NOUN admet-2022 49 22   PROPN admet-2022 49 23   NOUN admet-2022 49 24   PROPN admet-2022 49 25   PROPN admet-2022 49 26 ( ( PUNCT admet-2022 49 27 1 1 NUM admet-2022 49 28 ) ) PUNCT admet-2022 49 29 where where SCONJ admet-2022 49 30 , , PUNCT admet-2022 49 31 winitial winitial ADJ admet-2022 49 32 drug drug NOUN admet-2022 49 33 = = NOUN admet-2022 49 34 weight weight NOUN admet-2022 49 35 of of ADP admet-2022 49 36 the the DET admet-2022 49 37 initial initial ADJ admet-2022 49 38 drug drug NOUN admet-2022 49 39 added add VERB admet-2022 49 40 and and CCONJ admet-2022 49 41 wfree wfree NOUN admet-2022 49 42 drug drug NOUN admet-2022 49 43 = = NOUN admet-2022 49 44 weight weight NOUN admet-2022 49 45 of of ADP admet-2022 49 46 the the DET admet-2022 49 47 free free ADJ admet-2022 49 48 drug drug NOUN admet-2022 49 49 in in ADP admet-2022 49 50 the the DET admet-2022 49 51 supernatant supernatant NOUN admet-2022 49 52 . . PUNCT admet-2022 50 1 drug drug NOUN admet-2022 50 2 entrapment entrapment ADJ admet-2022 50 3 efficiency efficiency NOUN admet-2022 50 4 of of ADP admet-2022 50 5 liquid liquid ADJ admet-2022 50 6 and and CCONJ admet-2022 50 7 solid solid ADJ admet-2022 50 8 snedds snedds PROPN admet-2022 50 9 precise precise ADJ admet-2022 50 10 amounts amount NOUN admet-2022 50 11 of of ADP admet-2022 50 12 liquid liquid ADJ admet-2022 50 13 and and CCONJ admet-2022 50 14 solid solid ADJ admet-2022 50 15 snedds snedd NOUN admet-2022 50 16 equivalent equivalent ADJ admet-2022 50 17 to to ADP admet-2022 50 18 2 2 NUM admet-2022 50 19 mg mg NOUN admet-2022 50 20 of of ADP admet-2022 50 21 dox dox NOUN admet-2022 50 22 were be AUX admet-2022 50 23 diluted dilute VERB admet-2022 50 24 using use VERB admet-2022 50 25 methanol methanol NOUN admet-2022 50 26 to to PART admet-2022 50 27 obtain obtain VERB admet-2022 50 28 a a DET admet-2022 50 29 concentration concentration NOUN admet-2022 50 30 of of ADP admet-2022 50 31 0.2 0.2 NUM admet-2022 50 32 mg mg NUM admet-2022 50 33 ml-1 ml-1 PROPN admet-2022 50 34 . . PUNCT admet-2022 51 1 then then ADV admet-2022 51 2 the the DET admet-2022 51 3 solutions solution NOUN admet-2022 51 4 were be AUX admet-2022 51 5 analysed analyse VERB admet-2022 51 6 using use VERB admet-2022 51 7 a a DET admet-2022 51 8 uv uv NOUN admet-2022 51 9 spectrophotometer spectrophotometer NOUN admet-2022 51 10 at at ADP admet-2022 51 11 a a DET admet-2022 51 12 maximum maximum NOUN admet-2022 51 13 of of ADP admet-2022 51 14 266 266 NUM admet-2022 51 15 nm nm NOUN admet-2022 52 1 [ [ X admet-2022 52 2 15 15 NUM admet-2022 52 3 ] ] PUNCT admet-2022 52 4 . . PUNCT admet-2022 53 1 measurement measurement NOUN admet-2022 53 2 of of ADP admet-2022 53 3 particle/ particle/ NUM admet-2022 53 4 droplet droplet ADJ admet-2022 53 5 size size NOUN admet-2022 53 6 and and CCONJ admet-2022 53 7 zeta zeta NOUN admet-2022 53 8 potential potential ADJ admet-2022 53 9 nanosuspension nanosuspension NOUN admet-2022 53 10 , , PUNCT admet-2022 53 11 liquid liquid ADJ admet-2022 53 12 and and CCONJ admet-2022 53 13 solid solid ADJ admet-2022 53 14 snedds snedd NOUN admet-2022 53 15 were be AUX admet-2022 53 16 characterized characterize VERB admet-2022 53 17 by by ADP admet-2022 53 18 the the DET admet-2022 53 19 measurement measurement NOUN admet-2022 53 20 of of ADP admet-2022 53 21 the the DET admet-2022 53 22 droplet droplet ADJ admet-2022 53 23 or or CCONJ admet-2022 53 24 particle particle NOUN admet-2022 53 25 size size NOUN admet-2022 53 26 and and CCONJ admet-2022 53 27 zeta zeta NOUN admet-2022 53 28 potential potential NOUN admet-2022 53 29 by by ADP admet-2022 53 30 dynamic dynamic ADJ admet-2022 53 31 light light NOUN admet-2022 53 32 scattering scatter VERB admet-2022 53 33 ( ( PUNCT admet-2022 53 34 zetasizer zetasizer X admet-2022 53 35 nano nano NOUN admet-2022 53 36 zs-90 zs-90 ADJ admet-2022 53 37 , , PUNCT admet-2022 53 38 malvern malvern PROPN admet-2022 53 39 instruments instrument NOUN admet-2022 53 40 , , PUNCT admet-2022 53 41 worcestershire worcestershire NOUN admet-2022 53 42 , , PUNCT admet-2022 53 43 uk uk PROPN admet-2022 53 44 ) ) PUNCT admet-2022 53 45 . . PUNCT admet-2022 54 1 distilled distil VERB admet-2022 54 2 water water NOUN admet-2022 54 3 was be AUX admet-2022 54 4 used use VERB admet-2022 54 5 for for ADP admet-2022 54 6 the the DET admet-2022 54 7 dilution dilution NOUN admet-2022 54 8 of of ADP admet-2022 54 9 each each DET admet-2022 54 10 sample sample NOUN admet-2022 54 11 10 10 NUM admet-2022 54 12 times time NOUN admet-2022 54 13 and and CCONJ admet-2022 54 14 each each DET admet-2022 54 15 measurement measurement NOUN admet-2022 54 16 was be AUX admet-2022 54 17 repeated repeat VERB admet-2022 54 18 three three NUM admet-2022 54 19 times time NOUN admet-2022 55 1 [ [ X admet-2022 55 2 15,19,20 15,19,20 NUM admet-2022 55 3 ] ] PUNCT admet-2022 55 4 in in ADP admet-2022 55 5 vitro vitro X admet-2022 55 6 studies study NOUN admet-2022 55 7 in in ADP admet-2022 55 8 vitro vitro X admet-2022 55 9 dissolution dissolution NOUN admet-2022 55 10 study study NOUN admet-2022 55 11 of of ADP admet-2022 55 12 pure pure ADJ admet-2022 55 13 dox dox NOUN admet-2022 55 14 and and CCONJ admet-2022 55 15 nanosuspension nanosuspension NOUN admet-2022 55 16 ( ( PUNCT admet-2022 55 17 f f X admet-2022 55 18 ) ) PUNCT admet-2022 55 19 and and CCONJ admet-2022 55 20 release release VERB admet-2022 55 21 studies study NOUN admet-2022 55 22 of of ADP admet-2022 55 23 liquid liquid NOUN admet-2022 55 24 ( ( PUNCT admet-2022 55 25 l l NOUN admet-2022 55 26 ) ) PUNCT admet-2022 55 27 and and CCONJ admet-2022 55 28 solid solid ADJ admet-2022 55 29 ( ( PUNCT admet-2022 55 30 s s X admet-2022 55 31 ) ) PUNCT admet-2022 55 32 snedds snedd NOUN admet-2022 55 33 were be AUX admet-2022 55 34 performed perform VERB admet-2022 55 35 using use VERB admet-2022 55 36 pharma pharma PROPN admet-2022 55 37 test test NOUN admet-2022 55 38 dissolution dissolution PROPN admet-2022 55 39 tester tester PROPN admet-2022 55 40 type type PROPN admet-2022 55 41 ii ii PROPN admet-2022 55 42 ( ( PUNCT admet-2022 55 43 paddle paddle NOUN admet-2022 55 44 apparatus apparatus NOUN admet-2022 55 45 , , PUNCT admet-2022 55 46 sp6 sp6 NOUN admet-2022 55 47 - - PUNCT admet-2022 55 48 400 400 NUM admet-2022 55 49 hamburg hamburg PROPN admet-2022 55 50 , , PUNCT admet-2022 55 51 germany germany PROPN admet-2022 55 52 ) ) PUNCT admet-2022 55 53 , , PUNCT admet-2022 55 54 500 500 NUM admet-2022 55 55 ml ml NOUN admet-2022 55 56 of of ADP admet-2022 55 57 phosphate phosphate ADJ admet-2022 55 58 buffer buffer NOUN admet-2022 55 59 ph ph VERB admet-2022 55 60 6.8 6.8 NUM admet-2022 55 61 with with SCONJ admet-2022 55 62 1 1 NUM admet-2022 55 63 % % NOUN admet-2022 55 64 tween tween NOUN admet-2022 55 65 80 80 NUM admet-2022 55 66 was be AUX admet-2022 55 67 used use VERB admet-2022 55 68 as as ADP admet-2022 55 69 a a DET admet-2022 55 70 release release NOUN admet-2022 55 71 media medium NOUN admet-2022 55 72 and and CCONJ admet-2022 55 73 maintained maintain VERB admet-2022 55 74 at at ADP admet-2022 55 75 37±0.2 37±0.2 NUM admet-2022 55 76 ° ° NOUN admet-2022 55 77 c c NOUN admet-2022 55 78 and and CCONJ admet-2022 55 79 100 100 NUM admet-2022 55 80 rpm rpm NOUN admet-2022 56 1 [ [ X admet-2022 56 2 12 12 NUM admet-2022 56 3 ] ] PUNCT admet-2022 56 4 . . PUNCT admet-2022 57 1 in in ADP admet-2022 57 2 float float NOUN admet-2022 57 3 - - PUNCT admet-2022 57 4 a a DET admet-2022 57 5 - - PUNCT admet-2022 57 6 lyzer lyzer NOUN admet-2022 57 7 cellulose cellulose NOUN admet-2022 57 8 ester ester NOUN admet-2022 57 9 dialysis dialysis NOUN admet-2022 57 10 tubes tube NOUN admet-2022 57 11 ( ( PUNCT admet-2022 57 12 1 1 NUM admet-2022 57 13 ml ml NOUN admet-2022 57 14 , , PUNCT admet-2022 57 15 molecular molecular ADJ admet-2022 57 16 weight weight NOUN admet-2022 57 17 cut cut NOUN admet-2022 57 18 - - PUNCT admet-2022 57 19 off off NOUN admet-2022 57 20 of of ADP admet-2022 57 21 10 10 NUM admet-2022 57 22 kda kda NOUN admet-2022 57 23 , , PUNCT admet-2022 57 24 spectrum spectrum NOUN admet-2022 57 25 laboratories laboratory NOUN admet-2022 57 26 , , PUNCT admet-2022 57 27 los los PROPN admet-2022 57 28 angeles angeles PROPN admet-2022 57 29 , , PUNCT admet-2022 57 30 ca ca PROPN admet-2022 57 31 , , PUNCT admet-2022 57 32 usa usa PROPN admet-2022 57 33 ) ) PUNCT admet-2022 57 34 , , PUNCT admet-2022 57 35 8 8 NUM admet-2022 57 36 mg mg NOUN admet-2022 57 37 of of ADP admet-2022 57 38 pure pure ADJ admet-2022 57 39 drug drug NOUN admet-2022 57 40 and and CCONJ admet-2022 57 41 equivalent equivalent ADJ admet-2022 57 42 amounts amount NOUN admet-2022 57 43 of of ADP admet-2022 57 44 tested test VERB admet-2022 57 45 preparation preparation NOUN admet-2022 57 46 were be AUX admet-2022 57 47 added add VERB admet-2022 57 48 to to ADP admet-2022 57 49 the the DET admet-2022 57 50 dissolution dissolution NOUN admet-2022 57 51 apparatus apparatus NOUN admet-2022 57 52 . . PUNCT admet-2022 58 1 samples sample NOUN admet-2022 58 2 ( ( PUNCT admet-2022 58 3 3 3 NUM admet-2022 58 4 ml ml NOUN admet-2022 58 5 for for ADP admet-2022 58 6 each each PRON admet-2022 58 7 ) ) PUNCT admet-2022 58 8 were be AUX admet-2022 58 9 withdrawn withdraw VERB admet-2022 58 10 after after ADP admet-2022 58 11 ( ( PUNCT admet-2022 58 12 3 3 NUM admet-2022 58 13 , , PUNCT admet-2022 58 14 5 5 NUM admet-2022 58 15 , , PUNCT admet-2022 58 16 7 7 NUM admet-2022 58 17 , , PUNCT admet-2022 58 18 10 10 NUM admet-2022 58 19 and and CCONJ admet-2022 58 20 20 20 NUM admet-2022 58 21 min min NOUN admet-2022 58 22 ) ) PUNCT admet-2022 58 23 , , PUNCT admet-2022 58 24 then then ADV admet-2022 58 25 filtered filter VERB admet-2022 58 26 and and CCONJ admet-2022 58 27 tested test VERB admet-2022 58 28 spectrophotometrically spectrophotometrically ADV admet-2022 58 29 at at ADP admet-2022 58 30 266 266 NUM admet-2022 58 31 nm nm NOUN admet-2022 58 32 . . PUNCT admet-2022 59 1 the the DET admet-2022 59 2 volume volume NOUN admet-2022 59 3 was be AUX admet-2022 59 4 maintained maintain VERB admet-2022 59 5 by by ADP admet-2022 59 6 using use VERB admet-2022 59 7 freshly freshly ADV admet-2022 59 8 prepared prepare VERB admet-2022 59 9 phosphate phosphate ADJ admet-2022 59 10 buffer buffer NOUN admet-2022 59 11 . . PUNCT admet-2022 60 1 the the DET admet-2022 60 2 release release NOUN admet-2022 60 3 percent percent NOUN admet-2022 60 4 of of ADP admet-2022 60 5 dox dox NOUN admet-2022 60 6 after after SCONJ admet-2022 60 7 20 20 NUM admet-2022 60 8 min min NOUN admet-2022 60 9 was be AUX admet-2022 60 10 calculated calculate VERB admet-2022 60 11 . . PUNCT admet-2022 61 1 the the DET admet-2022 61 2 similarity similarity NOUN admet-2022 61 3 factor factor NOUN admet-2022 61 4 ( ( PUNCT admet-2022 61 5 f2 f2 PROPN admet-2022 61 6 ) ) PUNCT admet-2022 61 7 was be AUX admet-2022 61 8 calculated calculate VERB admet-2022 61 9 according accord VERB admet-2022 61 10 to to ADP admet-2022 61 11 equation equation NOUN admet-2022 61 12 ( ( PUNCT admet-2022 61 13 2 2 NUM admet-2022 61 14 ) ) PUNCT admet-2022 61 15 . . PUNCT admet-2022 62 1 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 62 2 a. a. PROPN admet-2022 62 3 z. z. PROPN admet-2022 62 4 g. g. PROPN admet-2022 62 5 al al PROPN admet-2022 62 6 ashmawy ashmawy PROPN admet-2022 62 7 et et PROPN admet-2022 62 8 al al PROPN admet-2022 62 9 . . PROPN admet-2022 62 10 admet admet PROPN admet-2022 62 11 & & CCONJ admet-2022 62 12 dmpk dmpk PROPN admet-2022 62 13 12(1 12(1 PROPN admet-2022 62 14 ) ) PUNCT admet-2022 62 15 ( ( PUNCT admet-2022 62 16 2024 2024 NUM admet-2022 62 17 ) ) PUNCT admet-2022 62 18 167 167 NUM admet-2022 62 19 - - SYM admet-2022 62 20 176 176 NUM admet-2022 62 21 170 170 NUM admet-2022 62 22 ( ( PUNCT admet-2022 62 23 ) ) PUNCT admet-2022 62 24 0.5 0.5 NUM admet-2022 62 25 1 1 NUM admet-2022 62 26 1 1 NUM admet-2022 62 27 f2 f2 PROPN admet-2022 62 28 50 50 NUM admet-2022 62 29 log log NOUN admet-2022 62 30 1 1 NUM admet-2022 62 31         SPACE admet-2022 62 32 100 100 NUM admet-2022 63 1 n n NUM admet-2022 63 2 t t NOUN admet-2022 63 3 t t NOUN admet-2022 63 4 r r NOUN admet-2022 63 5 wt wt NOUN admet-2022 63 6 r r NOUN admet-2022 63 7 t t NOUN admet-2022 63 8 n n CCONJ admet-2022 63 9 − − NOUN admet-2022 64 1 = = NOUN admet-2022 64 2   NOUN admet-2022 64 3   NOUN admet-2022 64 4 = = PUNCT admet-2022 65 1 + + NUM admet-2022 65 2 − − PROPN admet-2022 65 3   CCONJ admet-2022 66 1   PROPN admet-2022 66 2   NOUN admet-2022 66 3   X admet-2022 66 4 ( ( PUNCT admet-2022 66 5 2 2 NUM admet-2022 66 6 ) ) PUNCT admet-2022 66 7 where where SCONJ admet-2022 66 8 , , PUNCT admet-2022 66 9 n n NOUN admet-2022 66 10 = = NOUN admet-2022 66 11 number number NOUN admet-2022 66 12 of of ADP admet-2022 66 13 time time NOUN admet-2022 66 14 points point NOUN admet-2022 66 15 , , PUNCT admet-2022 66 16 wt wt NOUN admet-2022 66 17 = = PUNCT admet-2022 66 18 optional optional ADJ admet-2022 66 19 weighting weighting NOUN admet-2022 66 20 factor factor NOUN admet-2022 66 21 , , PUNCT admet-2022 66 22 r r NOUN admet-2022 66 23 = = PUNCT admet-2022 66 24 the the DET admet-2022 66 25 lower low ADJ admet-2022 66 26 limit limit NOUN admet-2022 66 27 of of ADP admet-2022 66 28 summation summation NOUN admet-2022 66 29 , , PUNCT admet-2022 66 30 rt rt PROPN admet-2022 66 31 / / SYM admet-2022 66 32 % % NOUN admet-2022 66 33 = = NOUN admet-2022 66 34 amount amount NOUN admet-2022 66 35 of of ADP admet-2022 66 36 drug drug NOUN admet-2022 66 37 dissolved dissolve VERB admet-2022 66 38 of of ADP admet-2022 66 39 reference reference NOUN admet-2022 66 40 product product NOUN admet-2022 66 41 at at ADP admet-2022 66 42 time time NOUN admet-2022 66 43 t t PROPN admet-2022 66 44 , , PUNCT admet-2022 66 45 and and CCONJ admet-2022 66 46 tt tt PROPN admet-2022 66 47 / / SYM admet-2022 66 48 % % NOUN admet-2022 67 1 = = NOUN admet-2022 67 2 amount amount NOUN admet-2022 67 3 of of ADP admet-2022 67 4 drug drug NOUN admet-2022 67 5 dissolved dissolve VERB admet-2022 67 6 of of ADP admet-2022 67 7 test test NOUN admet-2022 67 8 product product NOUN admet-2022 67 9 at at ADP admet-2022 67 10 that that DET admet-2022 67 11 same same ADJ admet-2022 67 12 time time NOUN admet-2022 67 13 point point NOUN admet-2022 67 14 . . PUNCT admet-2022 68 1 transmission transmission NOUN admet-2022 68 2 electron electron NOUN admet-2022 68 3 microscopy microscopy NOUN admet-2022 68 4 pure pure ADJ admet-2022 68 5 dox dox NOUN admet-2022 68 6 , , PUNCT admet-2022 68 7 nanosuspension nanosuspension NOUN admet-2022 68 8 , , PUNCT admet-2022 68 9 liquid liquid NOUN admet-2022 68 10 , , PUNCT admet-2022 68 11 and and CCONJ admet-2022 68 12 solid solid ADJ admet-2022 68 13 snedds snedd NOUN admet-2022 68 14 were be AUX admet-2022 68 15 imaged image VERB admet-2022 68 16 using use VERB admet-2022 68 17 transmission transmission NOUN admet-2022 68 18 electron electron NOUN admet-2022 68 19 microscop microscop NOUN admet-2022 68 20 ( ( PUNCT admet-2022 68 21 tem tem PROPN admet-2022 68 22 ) ) PUNCT admet-2022 68 23 ( ( PUNCT admet-2022 68 24 jeol jeol PROPN admet-2022 68 25 jem–2100 jem–2100 PROPN admet-2022 68 26 , , PUNCT admet-2022 68 27 jeol jeol PROPN admet-2022 68 28 ltd ltd PROPN admet-2022 68 29 , , PUNCT admet-2022 68 30 tokyo tokyo PROPN admet-2022 68 31 , , PUNCT admet-2022 68 32 japan japan PROPN admet-2022 68 33 ) ) PUNCT admet-2022 68 34 to to PART admet-2022 68 35 observe observe VERB admet-2022 68 36 their their PRON admet-2022 68 37 shape shape NOUN admet-2022 68 38 . . PUNCT admet-2022 69 1 each each PRON admet-2022 69 2 was be AUX admet-2022 69 3 diluted dilute VERB admet-2022 69 4 using use VERB admet-2022 69 5 distilled distil VERB admet-2022 69 6 water water NOUN admet-2022 69 7 and and CCONJ admet-2022 69 8 then then ADV admet-2022 69 9 added add VERB admet-2022 69 10 to to ADP admet-2022 69 11 carbon carbon NOUN admet-2022 69 12 - - PUNCT admet-2022 69 13 coated coat VERB admet-2022 69 14 grids grid NOUN admet-2022 69 15 . . PUNCT admet-2022 70 1 after after ADP admet-2022 70 2 this this PRON admet-2022 70 3 , , PUNCT admet-2022 70 4 2 2 NUM admet-2022 70 5 % % NOUN admet-2022 70 6 phospho phospho ADJ admet-2022 70 7 - - PUNCT admet-2022 70 8 tungstic tungstic NOUN admet-2022 70 9 acid acid NOUN admet-2022 70 10 was be AUX admet-2022 70 11 used use VERB admet-2022 70 12 for for ADP admet-2022 70 13 the the DET admet-2022 70 14 staining stain VERB admet-2022 70 15 and and CCONJ admet-2022 70 16 left leave VERB admet-2022 70 17 for for ADP admet-2022 70 18 30 30 NUM admet-2022 70 19 s. s. PROPN admet-2022 70 20 using use VERB admet-2022 70 21 vacuum vacuum NOUN admet-2022 70 22 dryers dryer NOUN admet-2022 70 23 , , PUNCT admet-2022 70 24 samples sample NOUN admet-2022 70 25 were be AUX admet-2022 70 26 dried dry VERB admet-2022 70 27 by by ADP admet-2022 70 28 air air NOUN admet-2022 70 29 and and CCONJ admet-2022 70 30 imaged image VERB admet-2022 70 31 by by ADP admet-2022 70 32 tem tem PROPN admet-2022 71 1 [ [ X admet-2022 71 2 21 21 NUM admet-2022 71 3 ] ] PUNCT admet-2022 71 4 . . PUNCT admet-2022 72 1 fourier fourier PROPN admet-2022 72 2 transform transform VERB admet-2022 72 3 infrared infrared ADJ admet-2022 72 4 spectroscopy spectroscopy NOUN admet-2022 72 5 to to PART admet-2022 72 6 detect detect VERB admet-2022 72 7 any any DET admet-2022 72 8 interaction interaction NOUN admet-2022 72 9 occurring occur VERB admet-2022 72 10 between between ADP admet-2022 72 11 dox dox NOUN admet-2022 72 12 and and CCONJ admet-2022 72 13 other other ADJ admet-2022 72 14 ingredients ingredient NOUN admet-2022 72 15 of of ADP admet-2022 72 16 nanosuspensions nanosuspension NOUN admet-2022 72 17 and and CCONJ admet-2022 72 18 snedds snedd VERB admet-2022 72 19 as as ADV admet-2022 72 20 well well ADV admet-2022 72 21 as as ADP admet-2022 72 22 solid solid ADJ admet-2022 72 23 snedds snedds NOUN admet-2022 72 24 , , PUNCT admet-2022 72 25 fourier fourier NOUN admet-2022 72 26 transform transform VERB admet-2022 72 27 infrared infrared ADJ admet-2022 72 28 spectroscopy spectroscopy NOUN admet-2022 72 29 ( ( PUNCT admet-2022 72 30 ftir ftir PROPN admet-2022 72 31 ) ) PUNCT admet-2022 72 32 ( ( PUNCT admet-2022 72 33 perkinelmer perkinelmer NOUN admet-2022 72 34 1600 1600 NUM admet-2022 72 35 ftir ftir PROPN admet-2022 72 36 spectrophotometer spectrophotometer PROPN admet-2022 72 37 , , PUNCT admet-2022 72 38 norwalk norwalk PROPN admet-2022 72 39 , , PUNCT admet-2022 72 40 usa usa PROPN admet-2022 72 41 ) ) PUNCT admet-2022 72 42 was be AUX admet-2022 72 43 used use VERB admet-2022 72 44 . . PUNCT admet-2022 73 1 200 200 NUM admet-2022 73 2 mg mg NOUN admet-2022 73 3 of of ADP admet-2022 73 4 kbr kbr PROPN admet-2022 73 5 was be AUX admet-2022 73 6 mixed mix VERB admet-2022 73 7 with with ADP admet-2022 73 8 each each PRON admet-2022 73 9 separately separately ADV admet-2022 73 10 , , PUNCT admet-2022 73 11 compressed compress VERB admet-2022 73 12 into into ADP admet-2022 73 13 discs disc NOUN admet-2022 73 14 and and CCONJ admet-2022 73 15 scanned scan VERB admet-2022 73 16 at at ADP admet-2022 73 17 a a DET admet-2022 73 18 rate rate NOUN admet-2022 73 19 of of ADP admet-2022 73 20 4 4 NUM admet-2022 73 21 mm mm NOUN admet-2022 73 22 s-1 s-1 NOUN admet-2022 73 23 in in ADP admet-2022 73 24 the the DET admet-2022 73 25 range range NOUN admet-2022 73 26 of of ADP admet-2022 73 27 4000 4000 NUM admet-2022 73 28 - - SYM admet-2022 73 29 400 400 NUM admet-2022 73 30 cm-1 cm-1 NOUN admet-2022 73 31 at at ADP admet-2022 73 32 1 1 NUM admet-2022 73 33 cm-1 cm-1 NOUN admet-2022 73 34 resolution resolution NOUN admet-2022 73 35 [ [ X admet-2022 73 36 21 21 NUM admet-2022 73 37 ] ] PUNCT admet-2022 73 38 . . PUNCT admet-2022 74 1 evaluation evaluation NOUN admet-2022 74 2 of of ADP admet-2022 74 3 the the DET admet-2022 74 4 antihypertensive antihypertensive ADJ admet-2022 74 5 effects effect NOUN admet-2022 74 6 of of ADP admet-2022 74 7 dox dox ADJ admet-2022 74 8 preparations preparation NOUN admet-2022 74 9 adult adult NOUN admet-2022 74 10 male male NOUN admet-2022 74 11 albino albino NOUN admet-2022 74 12 rats rat NOUN admet-2022 74 13 of of ADP admet-2022 74 14 an an DET admet-2022 74 15 average average ADJ admet-2022 74 16 weight weight NOUN admet-2022 74 17 ranging range VERB admet-2022 74 18 from from ADP admet-2022 74 19 200 200 NUM admet-2022 74 20 to to PART admet-2022 74 21 250 250 NUM admet-2022 74 22 g g NOUN admet-2022 74 23 were be AUX admet-2022 74 24 classified classify VERB admet-2022 74 25 into into ADP admet-2022 74 26 five five NUM admet-2022 74 27 groups group NOUN admet-2022 74 28 ( ( PUNCT admet-2022 74 29 each each DET admet-2022 74 30 group group NOUN admet-2022 74 31 contained contain VERB admet-2022 74 32 five five NUM admet-2022 74 33 rats rat NOUN admet-2022 74 34 ) ) PUNCT admet-2022 74 35 . . PUNCT admet-2022 75 1 each each DET admet-2022 75 2 group group NOUN admet-2022 75 3 received receive VERB admet-2022 75 4 the the DET admet-2022 75 5 treatment treatment NOUN admet-2022 75 6 mentioned mention VERB admet-2022 75 7 in in ADP admet-2022 75 8 table table NOUN admet-2022 75 9 1 1 NUM admet-2022 76 1 [ [ X admet-2022 76 2 22 22 NUM admet-2022 76 3 ] ] PUNCT admet-2022 76 4 using use VERB admet-2022 76 5 an an DET admet-2022 76 6 oral oral ADJ admet-2022 76 7 gavage gavage NOUN admet-2022 76 8 ( ( PUNCT admet-2022 76 9 instech instech PROPN admet-2022 76 10 laboratories laboratories PROPN admet-2022 76 11 inc inc PROPN admet-2022 76 12 . . PROPN admet-2022 76 13 , , PUNCT admet-2022 76 14 plymouth plymouth PROPN admet-2022 76 15 meeting meeting NOUN admet-2022 76 16 , , PUNCT admet-2022 76 17 pa pa PROPN admet-2022 76 18 , , PUNCT admet-2022 76 19 usa usa PROPN admet-2022 76 20 ) ) PUNCT admet-2022 76 21 . . PUNCT admet-2022 77 1 rats rat NOUN admet-2022 77 2 were be AUX admet-2022 77 3 purchased purchase VERB admet-2022 77 4 from from ADP admet-2022 77 5 an an DET admet-2022 77 6 animal animal NOUN admet-2022 77 7 breeding breeding NOUN admet-2022 77 8 centre centre NOUN admet-2022 77 9 ( ( PUNCT admet-2022 77 10 department department NOUN admet-2022 77 11 of of ADP admet-2022 77 12 pharmacology pharmacology NOUN admet-2022 77 13 , , PUNCT admet-2022 77 14 faculty faculty NOUN admet-2022 77 15 of of ADP admet-2022 77 16 medicine medicine NOUN admet-2022 77 17 ) ) PUNCT admet-2022 77 18 . . PUNCT admet-2022 78 1 hypertension hypertension NOUN admet-2022 78 2 was be AUX admet-2022 78 3 introduced introduce VERB admet-2022 78 4 to to ADP admet-2022 78 5 the the DET admet-2022 78 6 rats rat NOUN admet-2022 78 7 according accord VERB admet-2022 78 8 to to ADP admet-2022 78 9 the the DET admet-2022 78 10 parasuraman parasuraman NOUN admet-2022 78 11 and and CCONJ admet-2022 78 12 raveendran raveendran ADJ admet-2022 78 13 method method NOUN admet-2022 78 14 [ [ X admet-2022 78 15 23 23 NUM admet-2022 78 16 ] ] PUNCT admet-2022 78 17 . . PUNCT admet-2022 79 1 the the DET admet-2022 79 2 mean mean ADJ admet-2022 79 3 arterial arterial ADJ admet-2022 79 4 blood blood NOUN admet-2022 79 5 pressure pressure NOUN admet-2022 79 6 ( ( PUNCT admet-2022 79 7 map map NOUN admet-2022 79 8 ) ) PUNCT admet-2022 79 9 was be AUX admet-2022 79 10 calculated calculate VERB admet-2022 79 11 for for ADP admet-2022 79 12 each each DET admet-2022 79 13 rat rat NOUN admet-2022 79 14 after after ADP admet-2022 79 15 treatment treatment NOUN admet-2022 79 16 with with ADP admet-2022 79 17 different different ADJ admet-2022 79 18 dox dox ADJ admet-2022 79 19 preparations preparation NOUN admet-2022 79 20 using use VERB admet-2022 79 21 equation equation NOUN admet-2022 79 22 3 3 NUM admet-2022 79 23 [ [ X admet-2022 79 24 24 24 NUM admet-2022 79 25 ] ] PUNCT admet-2022 79 26 . . PUNCT admet-2022 79 27     SPACE admet-2022 79 28 systolic systolic ADJ admet-2022 79 29     SPACE admet-2022 79 30 bp bp PROPN admet-2022 79 31 diastolic diastolic PROPN admet-2022 79 32     SPACE admet-2022 79 33 bp bp PROPN admet-2022 79 34 map map VERB admet-2022 79 35 diastolic diastolic NOUN admet-2022 79 36     SPACE admet-2022 79 37 bp bp PROPN admet-2022 79 38 3 3 NUM admet-2022 80 1 = = SYM admet-2022 80 2 + + CCONJ admet-2022 80 3 ( ( PUNCT admet-2022 80 4 3 3 NUM admet-2022 80 5 ) ) PUNCT admet-2022 80 6 where where SCONJ admet-2022 80 7 , , PUNCT admet-2022 80 8 bp bp PROPN admet-2022 80 9 is be AUX admet-2022 80 10 the the DET admet-2022 80 11 rat rat NOUN admet-2022 80 12 ’s ’s PART admet-2022 80 13 blood blood NOUN admet-2022 80 14 pressure pressure NOUN admet-2022 80 15 . . PUNCT admet-2022 81 1 table table NOUN admet-2022 81 2 1 1 NUM admet-2022 81 3 . . PUNCT admet-2022 82 1 classification classification NOUN admet-2022 82 2 of of ADP admet-2022 82 3 the the DET admet-2022 82 4 five five NUM admet-2022 82 5 rat rat NOUN admet-2022 82 6 groups group NOUN admet-2022 82 7 treatment treatment NOUN admet-2022 82 8 group group NOUN admet-2022 82 9 no no INTJ admet-2022 82 10 . . PUNCT admet-2022 83 1 hypertensive hypertensive ADJ admet-2022 83 2 rats rat NOUN admet-2022 83 3 treated treat VERB admet-2022 83 4 by by ADP admet-2022 83 5 market market NOUN admet-2022 83 6 tablet tablet NOUN admet-2022 83 7 dosin dosin NOUN admet-2022 83 8 ® ® NOUN admet-2022 83 9 i i PRON admet-2022 83 10 hypertensive hypertensive VERB admet-2022 83 11 rats rat NOUN admet-2022 83 12 treated treat VERB admet-2022 83 13 by by ADP admet-2022 83 14 nanosuspension nanosuspension NOUN admet-2022 83 15 containing contain VERB admet-2022 83 16 12 12 NUM admet-2022 83 17 mg mg NOUN admet-2022 83 18 of of ADP admet-2022 83 19 dox dox NOUN admet-2022 83 20 nanosuspension nanosuspension NOUN admet-2022 83 21 ( ( PUNCT admet-2022 83 22 equivalent equivalent ADJ admet-2022 83 23 to to ADP admet-2022 83 24 4 4 NUM admet-2022 83 25 mg mg PROPN admet-2022 83 26 dox dox NOUN admet-2022 83 27 ) ) PUNCT admet-2022 83 28 ii ii PROPN admet-2022 83 29 hypertensive hypertensive ADJ admet-2022 83 30 rats rat NOUN admet-2022 83 31 treated treat VERB admet-2022 83 32 with with ADP admet-2022 83 33 1.2 1.2 NUM admet-2022 83 34 ml ml NOUN admet-2022 83 35 of of ADP admet-2022 83 36 a a DET admet-2022 83 37 selected select VERB admet-2022 83 38 formula formula NOUN admet-2022 83 39 of of ADP admet-2022 83 40 liquid liquid ADJ admet-2022 83 41 snnedds snnedd NOUN admet-2022 83 42 ( ( PUNCT admet-2022 83 43 equivalent equivalent ADJ admet-2022 83 44 to to ADP admet-2022 83 45 4 4 NUM admet-2022 83 46 mg mg PROPN admet-2022 83 47 dox dox NOUN admet-2022 83 48 ) ) PUNCT admet-2022 83 49 iii iii NUM admet-2022 83 50 hypertensive hypertensive ADJ admet-2022 83 51 rats rat NOUN admet-2022 83 52 treated treat VERB admet-2022 83 53 with with ADP admet-2022 83 54 1230 1230 NUM admet-2022 83 55 mg mg NOUN admet-2022 83 56 of of ADP admet-2022 83 57 a a DET admet-2022 83 58 selected select VERB admet-2022 83 59 formula formula NOUN admet-2022 83 60 of of ADP admet-2022 83 61 solid solid ADJ admet-2022 83 62 snnedds snnedd NOUN admet-2022 83 63 ( ( PUNCT admet-2022 83 64 equivalent equivalent ADJ admet-2022 83 65 to to ADP admet-2022 83 66 4 4 NUM admet-2022 83 67 mg mg PROPN admet-2022 83 68 dox dox NOUN admet-2022 83 69 ) ) PUNCT admet-2022 83 70 redispersed redisperse VERB admet-2022 83 71 in in ADP admet-2022 83 72 1 1 NUM admet-2022 83 73 ml ml NOUN admet-2022 83 74 of of ADP admet-2022 83 75 distilled distil VERB admet-2022 83 76 water water NOUN admet-2022 83 77 . . PUNCT admet-2022 84 1 iv iv NUM admet-2022 84 2 untreated untreated ADJ admet-2022 84 3 hypertensive hypertensive ADJ admet-2022 84 4 rats rat NOUN admet-2022 84 5 ( ( PUNCT admet-2022 84 6 positive positive ADJ admet-2022 84 7 control control NOUN admet-2022 84 8 ) ) PUNCT admet-2022 84 9 v v ADP admet-2022 84 10 statistical statistical ADJ admet-2022 84 11 analysis analysis NOUN admet-2022 84 12 both both CCONJ admet-2022 84 13 in in ADP admet-2022 84 14 vitro vitro X admet-2022 84 15 and and CCONJ admet-2022 84 16 in in ADP admet-2022 84 17 vivo vivo ADJ admet-2022 84 18 data datum NOUN admet-2022 84 19 ( ( PUNCT admet-2022 84 20 percent percent NOUN admet-2022 84 21 drug drug NOUN admet-2022 84 22 release release NOUN admet-2022 84 23 after after ADP admet-2022 84 24 3 3 NUM admet-2022 84 25 , , PUNCT admet-2022 84 26 5 5 NUM admet-2022 84 27 , , PUNCT admet-2022 84 28 7 7 NUM admet-2022 84 29 , , PUNCT admet-2022 84 30 10 10 NUM admet-2022 84 31 and and CCONJ admet-2022 84 32 20 20 NUM admet-2022 84 33 min min NOUN admet-2022 84 34 and and CCONJ admet-2022 84 35 mean mean VERB admet-2022 84 36 arterial arterial ADJ admet-2022 84 37 blood blood NOUN admet-2022 84 38 pressure pressure NOUN admet-2022 84 39 of of ADP admet-2022 84 40 the the DET admet-2022 84 41 rats rat NOUN admet-2022 84 42 after after ADP admet-2022 84 43 0 0 NUM admet-2022 84 44 , , PUNCT admet-2022 84 45 15 15 NUM admet-2022 84 46 , , PUNCT admet-2022 84 47 30 30 NUM admet-2022 84 48 , , PUNCT admet-2022 84 49 60 60 NUM admet-2022 84 50 , , PUNCT admet-2022 84 51 90 90 NUM admet-2022 84 52 , , PUNCT admet-2022 84 53 120 120 NUM admet-2022 84 54 and and CCONJ admet-2022 84 55 180 180 NUM admet-2022 84 56 min min NOUN admet-2022 84 57 , , PUNCT admet-2022 84 58 respectively respectively ADV admet-2022 84 59 ) ) PUNCT admet-2022 84 60 were be AUX admet-2022 84 61 statistically statistically ADV admet-2022 84 62 analysed analyse VERB admet-2022 84 63 using use VERB admet-2022 84 64 one one NUM admet-2022 84 65 - - PUNCT admet-2022 84 66 way way NOUN admet-2022 84 67 analysis analysis NOUN admet-2022 84 68 of of ADP admet-2022 84 69 variance variance NOUN admet-2022 84 70 ( ( PUNCT admet-2022 84 71 anova anova PROPN admet-2022 84 72 ) ) PUNCT admet-2022 84 73 using use VERB admet-2022 84 74 minitab minitab PROPN admet-2022 84 75 software software NOUN admet-2022 84 76 , , PUNCT admet-2022 84 77 version version NOUN admet-2022 84 78 17 17 NUM admet-2022 84 79 and and CCONJ admet-2022 84 80 the the DET admet-2022 84 81 parameters parameter NOUN admet-2022 84 82 were be AUX admet-2022 84 83 significant significant ADJ admet-2022 84 84 for for ADP admet-2022 84 85 the the DET admet-2022 84 86 p p X admet-2022 84 87 < < X admet-2022 84 88 0.05 0.05 NUM admet-2022 84 89 . . PUNCT admet-2022 85 1 admet admet PROPN admet-2022 85 2 & & CCONJ admet-2022 85 3 dmpk dmpk PROPN admet-2022 85 4 12(1 12(1 PROPN admet-2022 85 5 ) ) PUNCT admet-2022 85 6 ( ( PUNCT admet-2022 85 7 2024 2024 NUM admet-2022 85 8 ) ) PUNCT admet-2022 85 9 167 167 NUM admet-2022 85 10 - - SYM admet-2022 85 11 176 176 NUM admet-2022 85 12 nanosuspension nanosuspension NOUN admet-2022 85 13 versus versus ADP admet-2022 85 14 self self NOUN admet-2022 85 15 - - PUNCT admet-2022 85 16 nanoemulsifying nanoemulsifye VERB admet-2022 85 17 drug drug NOUN admet-2022 85 18 delivery delivery NOUN admet-2022 85 19 doi doi NOUN admet-2022 85 20 : : PUNCT admet-2022 85 21 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 85 22 171 171 NUM admet-2022 85 23 results result NOUN admet-2022 85 24 and and CCONJ admet-2022 85 25 discussion discussion NOUN admet-2022 85 26 drug drug NOUN admet-2022 85 27 content content NOUN admet-2022 85 28 and and CCONJ admet-2022 85 29 entrapment entrapment ADJ admet-2022 85 30 efficiency efficiency NOUN admet-2022 85 31 determination determination NOUN admet-2022 85 32 the the DET admet-2022 85 33 drug drug NOUN admet-2022 85 34 content content NOUN admet-2022 85 35 of of ADP admet-2022 85 36 the the DET admet-2022 85 37 dox dox NOUN admet-2022 85 38 nanosuspension nanosuspension NOUN admet-2022 85 39 formulation formulation NOUN admet-2022 85 40 was be AUX admet-2022 85 41 99.99 99.99 NUM admet-2022 85 42 , , PUNCT admet-2022 85 43 demonstrating demonstrate VERB admet-2022 85 44 the the DET admet-2022 85 45 correctness correctness NOUN admet-2022 85 46 of of ADP admet-2022 85 47 the the DET admet-2022 85 48 preparation preparation NOUN admet-2022 85 49 procedure procedure NOUN admet-2022 85 50 ( ( PUNCT admet-2022 85 51 emulsification emulsification NOUN admet-2022 85 52 solvent solvent NOUN admet-2022 85 53 diffusion diffusion NOUN admet-2022 85 54 ) ) PUNCT admet-2022 86 1 [ [ X admet-2022 86 2 25 25 NUM admet-2022 86 3 ] ] PUNCT admet-2022 86 4 . . PUNCT admet-2022 87 1 both both PRON admet-2022 87 2 solid solid ADJ admet-2022 87 3 and and CCONJ admet-2022 87 4 liquid liquid ADJ admet-2022 87 5 sneeds sneed NOUN admet-2022 87 6 had have VERB admet-2022 87 7 a a DET admet-2022 87 8 100 100 NUM admet-2022 87 9 % % NOUN admet-2022 87 10 entrapment entrapment ADJ admet-2022 87 11 efficiency efficiency NOUN admet-2022 87 12 . . PUNCT admet-2022 88 1 tween tween NOUN admet-2022 88 2 80 80 NUM admet-2022 88 3 has have VERB admet-2022 88 4 a a DET admet-2022 88 5 high high ADJ admet-2022 88 6 hydrophiliclipophilic hydrophiliclipophilic ADJ admet-2022 88 7 balance balance NOUN admet-2022 88 8 ( ( PUNCT admet-2022 88 9 hlb hlb PROPN admet-2022 88 10 ) ) PUNCT admet-2022 88 11 value value NOUN admet-2022 88 12 of of ADP admet-2022 88 13 15 15 NUM admet-2022 88 14 and and CCONJ admet-2022 88 15 enhances enhance VERB admet-2022 88 16 the the DET admet-2022 88 17 drug drug NOUN admet-2022 88 18 solubility solubility NOUN admet-2022 88 19 in in ADP admet-2022 88 20 oleic oleic NOUN admet-2022 88 21 acid acid PROPN admet-2022 88 22 with with ADP admet-2022 88 23 a a DET admet-2022 88 24 subsequent subsequent ADJ admet-2022 88 25 increase increase NOUN admet-2022 88 26 in in ADP admet-2022 88 27 entrapment entrapment ADJ admet-2022 88 28 efficiency efficiency NOUN admet-2022 89 1 [ [ X admet-2022 89 2 26 26 NUM admet-2022 89 3 ] ] PUNCT admet-2022 89 4 . . PUNCT admet-2022 90 1 measurement measurement NOUN admet-2022 90 2 of of ADP admet-2022 90 3 particle particle NOUN admet-2022 90 4 / / SYM admet-2022 90 5 droplet droplet ADJ admet-2022 90 6 size size NOUN admet-2022 90 7 and and CCONJ admet-2022 90 8 zeta zeta NOUN admet-2022 90 9 potential potential NOUN admet-2022 90 10 of of ADP admet-2022 90 11 dox dox NOUN admet-2022 90 12 nanosuspension nanosuspension NOUN admet-2022 90 13 , , PUNCT admet-2022 90 14 liquid liquid ADJ admet-2022 90 15 and and CCONJ admet-2022 90 16 solid solid ADJ admet-2022 90 17 snedds snedd NOUN admet-2022 90 18 both both CCONJ admet-2022 90 19 liquid liquid ADJ admet-2022 90 20 ( ( PUNCT admet-2022 90 21 l l NOUN admet-2022 90 22 ) ) PUNCT admet-2022 90 23 and and CCONJ admet-2022 90 24 solid solid ADJ admet-2022 90 25 ( ( PUNCT admet-2022 90 26 s s X admet-2022 90 27 ) ) PUNCT admet-2022 90 28 snedds snedd NOUN admet-2022 90 29 exhibited exhibit VERB admet-2022 90 30 lower low ADJ admet-2022 90 31 droplet droplet ADJ admet-2022 90 32 / / SYM admet-2022 90 33 particle particle NOUN admet-2022 90 34 size size NOUN admet-2022 90 35 than than ADP admet-2022 90 36 dox dox NOUN admet-2022 90 37 nanosuspension nanosuspension NOUN admet-2022 90 38 ( ( PUNCT admet-2022 90 39 f f X admet-2022 90 40 ) ) PUNCT admet-2022 90 41 , , PUNCT admet-2022 90 42 as as SCONJ admet-2022 90 43 shown show VERB admet-2022 90 44 in in ADP admet-2022 90 45 table table NOUN admet-2022 90 46 2 2 NUM admet-2022 90 47 . . PUNCT admet-2022 91 1 this this DET admet-2022 91 2 result result NOUN admet-2022 91 3 may may AUX admet-2022 91 4 be be AUX admet-2022 91 5 ascribed ascribe VERB admet-2022 91 6 to to ADP admet-2022 91 7 the the DET admet-2022 91 8 presence presence NOUN admet-2022 91 9 of of ADP admet-2022 91 10 a a DET admet-2022 91 11 combination combination NOUN admet-2022 91 12 of of ADP admet-2022 91 13 three three NUM admet-2022 91 14 stabilizers stabilizer NOUN admet-2022 91 15 for for ADP admet-2022 91 16 nanosuspension nanosuspension NOUN admet-2022 91 17 preparation preparation NOUN admet-2022 91 18 in in ADP admet-2022 91 19 which which PRON admet-2022 91 20 their their PRON admet-2022 91 21 amounts amount NOUN admet-2022 91 22 should should AUX admet-2022 91 23 be be AUX admet-2022 91 24 controlled control VERB admet-2022 91 25 to to PART admet-2022 91 26 obtain obtain VERB admet-2022 91 27 particles particle NOUN admet-2022 91 28 in in ADP admet-2022 91 29 the the DET admet-2022 91 30 nano nano NOUN admet-2022 91 31 range range NOUN admet-2022 91 32 . . PUNCT admet-2022 92 1 on on ADP admet-2022 92 2 the the DET admet-2022 92 3 other other ADJ admet-2022 92 4 hand hand NOUN admet-2022 92 5 , , PUNCT admet-2022 92 6 snedds snedd NOUN admet-2022 92 7 were be AUX admet-2022 92 8 prepared prepare VERB admet-2022 92 9 in in ADP admet-2022 92 10 oil oil NOUN admet-2022 92 11 : : PUNCT admet-2022 92 12 smix smix NOUN admet-2022 92 13 of of ADP admet-2022 92 14 1:9 1:9 NUM admet-2022 92 15 w w PROPN admet-2022 92 16 / / SYM admet-2022 92 17 w w PROPN admet-2022 92 18 , , PUNCT admet-2022 92 19 which which PRON admet-2022 92 20 was be AUX admet-2022 92 21 previously previously ADV admet-2022 92 22 reported report VERB admet-2022 92 23 to to PART admet-2022 92 24 produce produce VERB admet-2022 92 25 systems system NOUN admet-2022 92 26 of of ADP admet-2022 92 27 nanosized nanosized ADJ admet-2022 92 28 droplets droplet NOUN admet-2022 92 29 ( ( PUNCT admet-2022 92 30 20 20 NUM admet-2022 92 31 to to PART admet-2022 92 32 200 200 NUM admet-2022 92 33 nm nm NOUN admet-2022 92 34 ) ) PUNCT admet-2022 93 1 [ [ X admet-2022 93 2 27 27 NUM admet-2022 93 3 ] ] PUNCT admet-2022 93 4 . . PUNCT admet-2022 94 1 nanosuspension nanosuspension PROPN admet-2022 94 2 's 's PART admet-2022 94 3 zeta zeta NOUN admet-2022 94 4 potential potential NOUN admet-2022 94 5 is be AUX admet-2022 94 6 50.33±4.2 50.33±4.2 PROPN admet-2022 94 7 mv mv PROPN admet-2022 94 8 owing owe VERB admet-2022 94 9 to to ADP admet-2022 94 10 its its PRON admet-2022 94 11 composition composition NOUN admet-2022 94 12 ( ( PUNCT admet-2022 94 13 pvp pvp NOUN admet-2022 94 14 k k PROPN admet-2022 94 15 30 30 NUM admet-2022 94 16 , , PUNCT admet-2022 94 17 poloxamer poloxamer NOUN admet-2022 94 18 407 407 NUM admet-2022 94 19 and and CCONJ admet-2022 94 20 sls sls PROPN admet-2022 94 21 ) ) PUNCT admet-2022 94 22 , , PUNCT admet-2022 94 23 which which PRON admet-2022 94 24 is be AUX admet-2022 94 25 considered consider VERB admet-2022 94 26 stable stable ADJ admet-2022 94 27 in in ADP admet-2022 94 28 contrast contrast NOUN admet-2022 94 29 with with ADP admet-2022 94 30 both both PRON admet-2022 94 31 l l NOUN admet-2022 94 32 and and CCONJ admet-2022 94 33 s s AUX admet-2022 94 34 possessing possess VERB admet-2022 94 35 lower low ADJ admet-2022 94 36 values value NOUN admet-2022 94 37 and and CCONJ admet-2022 94 38 considered consider VERB admet-2022 94 39 electrokinetically electrokinetically ADV admet-2022 94 40 unstable unstable ADJ admet-2022 94 41 . . PUNCT admet-2022 95 1 comparing compare VERB admet-2022 95 2 the the DET admet-2022 95 3 zeta zeta NOUN admet-2022 95 4 potentials potential NOUN admet-2022 95 5 of of ADP admet-2022 95 6 both both DET admet-2022 95 7 l l NOUN admet-2022 95 8 and and CCONJ admet-2022 95 9 s s X admet-2022 95 10 , , PUNCT admet-2022 95 11 it it PRON admet-2022 95 12 was be AUX admet-2022 95 13 found find VERB admet-2022 95 14 that that SCONJ admet-2022 95 15 s s AUX admet-2022 95 16 possesses possess VERB admet-2022 95 17 a a DET admet-2022 95 18 higher high ADJ admet-2022 95 19 value value NOUN admet-2022 95 20 than than ADP admet-2022 95 21 l l NOUN admet-2022 95 22 , , PUNCT admet-2022 95 23 possibly possibly ADV admet-2022 95 24 due due ADP admet-2022 95 25 to to ADP admet-2022 95 26 the the DET admet-2022 95 27 presence presence NOUN admet-2022 95 28 of of ADP admet-2022 95 29 an an DET admet-2022 95 30 adsorbent adsorbent NOUN admet-2022 95 31 mixture mixture NOUN admet-2022 95 32 . . PUNCT admet-2022 96 1 the the DET admet-2022 96 2 negative negative ADJ admet-2022 96 3 sign sign NOUN admet-2022 96 4 of of ADP admet-2022 96 5 zeta zeta PROPN admet-2022 96 6 potential potential NOUN admet-2022 96 7 is be AUX admet-2022 96 8 mainly mainly ADV admet-2022 96 9 due due ADJ admet-2022 96 10 to to ADP admet-2022 96 11 the the DET admet-2022 96 12 oil oil NOUN admet-2022 96 13 content content NOUN admet-2022 96 14 [ [ X admet-2022 96 15 28 28 NUM admet-2022 96 16 ] ] PUNCT admet-2022 96 17 , , PUNCT admet-2022 96 18 with with ADP admet-2022 96 19 the the DET admet-2022 96 20 adsorbent adsorbent NOUN admet-2022 96 21 mixture mixture NOUN admet-2022 96 22 contributing contribute VERB admet-2022 96 23 to to ADP admet-2022 96 24 the the DET admet-2022 96 25 negative negative ADJ admet-2022 96 26 sign sign NOUN admet-2022 96 27 of of ADP admet-2022 96 28 zeta zeta PROPN admet-2022 96 29 potential potential NOUN admet-2022 96 30 . . PUNCT admet-2022 97 1 aerosil aerosil NOUN admet-2022 97 2 200 200 NUM admet-2022 97 3 adsorbs adsorb VERB admet-2022 97 4 protons proton NOUN admet-2022 97 5 on on ADP admet-2022 97 6 its its PRON admet-2022 97 7 surface surface NOUN admet-2022 97 8 , , PUNCT admet-2022 97 9 leading lead VERB admet-2022 97 10 to to ADP admet-2022 97 11 the the DET admet-2022 97 12 ionization ionization NOUN admet-2022 97 13 of of ADP admet-2022 97 14 its its PRON admet-2022 97 15 silanol silanol NOUN admet-2022 97 16 groups group NOUN admet-2022 97 17 [ [ X admet-2022 97 18 29 29 NUM admet-2022 97 19 ] ] PUNCT admet-2022 97 20 , , PUNCT admet-2022 97 21 and and CCONJ admet-2022 97 22 avicel avicel VERB admet-2022 97 23 101 101 NUM admet-2022 97 24 also also ADV admet-2022 97 25 adsorbs adsorb VERB admet-2022 97 26 sulphate sulphate NOUN admet-2022 97 27 ions ion NOUN admet-2022 97 28 on on ADP admet-2022 97 29 its its PRON admet-2022 97 30 surface surface NOUN admet-2022 98 1 [ [ X admet-2022 98 2 30 30 NUM admet-2022 98 3 ] ] PUNCT admet-2022 98 4 . . PUNCT admet-2022 99 1 table table NOUN admet-2022 99 2 2 2 NUM admet-2022 99 3 . . PUNCT admet-2022 99 4 particle particle NOUN admet-2022 99 5 size size NOUN admet-2022 99 6 and and CCONJ admet-2022 99 7 zeta zeta NOUN admet-2022 99 8 potential potential NOUN admet-2022 99 9 of of ADP admet-2022 99 10 nanosuspension nanosuspension NOUN admet-2022 99 11 , , PUNCT admet-2022 99 12 liquid liquid ADJ admet-2022 99 13 snedds snedd NOUN admet-2022 99 14 and and CCONJ admet-2022 99 15 solid solid ADJ admet-2022 99 16 snedds snedds PROPN admet-2022 99 17 . . PUNCT admet-2022 100 1 formula formula NOUN admet-2022 100 2 particle particle NOUN admet-2022 100 3 size size NOUN admet-2022 100 4 , , PUNCT admet-2022 100 5 nm nm NOUN admet-2022 100 6 zeta zeta NOUN admet-2022 100 7 potential potential NOUN admet-2022 100 8 , , PUNCT admet-2022 100 9 mv mv PROPN admet-2022 100 10 poly poly ADJ admet-2022 100 11 - - PUNCT admet-2022 100 12 dispersity dispersity NOUN admet-2022 100 13 index index NOUN admet-2022 100 14 f f PROPN admet-2022 100 15 385.00±13.00 385.00±13.00 NUM admet-2022 100 16 50.33±4.20 50.33±4.20 NUM admet-2022 100 17 0.44±0.01 0.44±0.01 NOUN admet-2022 100 18 l l NOUN admet-2022 100 19 224.40±15.55 224.40±15.55 NUM admet-2022 100 20 -5.57±0.10 -5.57±0.10 VERB admet-2022 100 21 1.00±0.00 1.00±0.00 NUM admet-2022 100 22 s s PART admet-2022 100 23 79.80±14.39 79.80±14.39 NUM admet-2022 100 24 -18.10±0.26 -18.10±0.26 NOUN admet-2022 100 25 0.47±0.01 0.47±0.01 NOUN admet-2022 100 26 in in ADP admet-2022 100 27 vitro vitro X admet-2022 100 28 evaluation evaluation NOUN admet-2022 100 29 of of ADP admet-2022 100 30 dox dox NOUN admet-2022 100 31 nanosuspension nanosuspension NOUN admet-2022 100 32 , , PUNCT admet-2022 100 33 liquid liquid ADJ admet-2022 100 34 and and CCONJ admet-2022 100 35 solid solid ADJ admet-2022 100 36 snedds snedd NOUN admet-2022 100 37 ( ( PUNCT admet-2022 100 38 f f X admet-2022 100 39 , , PUNCT admet-2022 100 40 l l PROPN admet-2022 100 41 and and CCONJ admet-2022 100 42 s s NOUN admet-2022 100 43 ) ) PUNCT admet-2022 100 44 release release NOUN admet-2022 100 45 percentages percentage NOUN admet-2022 100 46 of of ADP admet-2022 100 47 different different ADJ admet-2022 100 48 dox dox NOUN admet-2022 100 49 formulations formulation NOUN admet-2022 100 50 and and CCONJ admet-2022 100 51 their their PRON admet-2022 100 52 release release NOUN admet-2022 100 53 profiles profile NOUN admet-2022 100 54 compared compare VERB admet-2022 100 55 with with ADP admet-2022 100 56 pure pure ADJ admet-2022 100 57 dox dox NOUN admet-2022 100 58 are be AUX admet-2022 100 59 presented present VERB admet-2022 100 60 in in ADP admet-2022 100 61 figure figure NOUN admet-2022 100 62 1 1 NUM admet-2022 100 63 . . PUNCT admet-2022 101 1 pure pure ADJ admet-2022 101 2 dox dox NOUN admet-2022 101 3 exhibited exhibit VERB admet-2022 101 4 poor poor ADJ admet-2022 101 5 release release NOUN admet-2022 101 6 properties property NOUN admet-2022 101 7 , , PUNCT admet-2022 101 8 about about ADV admet-2022 101 9 39±1.00 39±1.00 NUM admet-2022 101 10 % % NOUN admet-2022 101 11 . . PUNCT admet-2022 102 1 it it PRON admet-2022 102 2 was be AUX admet-2022 102 3 91± 91± NUM admet-2022 102 4 0.43 0.43 NUM admet-2022 102 5 % % NOUN admet-2022 102 6 , , PUNCT admet-2022 102 7 93± 93± NUM admet-2022 102 8 4.47 4.47 NUM admet-2022 102 9 % % NOUN admet-2022 102 10 and and CCONJ admet-2022 102 11 100±2.72 100±2.72 NUM admet-2022 102 12 % % NOUN admet-2022 102 13 for for ADP admet-2022 102 14 f f PROPN admet-2022 102 15 , , PUNCT admet-2022 102 16 l l PROPN admet-2022 102 17 and and CCONJ admet-2022 102 18 s s PROPN admet-2022 102 19 , , PUNCT admet-2022 102 20 respectively respectively ADV admet-2022 102 21 . . PUNCT admet-2022 103 1 it it PRON admet-2022 103 2 is be AUX admet-2022 103 3 worth worth ADJ admet-2022 103 4 mentioning mention VERB admet-2022 103 5 that that SCONJ admet-2022 103 6 the the DET admet-2022 103 7 formulation formulation NOUN admet-2022 103 8 of of ADP admet-2022 103 9 dox dox NOUN admet-2022 103 10 , , PUNCT admet-2022 103 11 either either CCONJ admet-2022 103 12 nanosuspension nanosuspension NOUN admet-2022 103 13 or or CCONJ admet-2022 103 14 snedds snedds PROPN admet-2022 103 15 , , PUNCT admet-2022 103 16 had have VERB admet-2022 103 17 a a DET admet-2022 103 18 significant significant ADJ admet-2022 103 19 effect effect NOUN admet-2022 103 20 on on ADP admet-2022 103 21 the the DET admet-2022 103 22 enhancement enhancement NOUN admet-2022 103 23 of of ADP admet-2022 103 24 release release NOUN admet-2022 103 25 properties property NOUN admet-2022 103 26 ( ( PUNCT admet-2022 103 27 about about ADP admet-2022 103 28 a a DET admet-2022 103 29 twofold twofold NOUN admet-2022 103 30 increase increase NOUN admet-2022 103 31 ) ) PUNCT admet-2022 103 32 compared compare VERB admet-2022 103 33 with with ADP admet-2022 103 34 its its PRON admet-2022 103 35 pure pure ADJ admet-2022 103 36 form form NOUN admet-2022 103 37 . . PUNCT admet-2022 104 1 however however ADV admet-2022 104 2 , , PUNCT admet-2022 104 3 solid solid ADJ admet-2022 104 4 snedds snedd NOUN admet-2022 104 5 had have VERB admet-2022 104 6 a a DET admet-2022 104 7 superior superior ADJ admet-2022 104 8 effect effect NOUN admet-2022 104 9 compared compare VERB admet-2022 104 10 to to ADP admet-2022 104 11 liquid liquid ADJ admet-2022 104 12 snedds snedd NOUN admet-2022 104 13 and and CCONJ admet-2022 104 14 dox dox NOUN admet-2022 104 15 nanosuspension nanosuspension NOUN admet-2022 104 16 ( ( PUNCT admet-2022 104 17 p p X admet-2022 104 18 < < X admet-2022 104 19 0.05 0.05 NUM admet-2022 104 20 ) ) PUNCT admet-2022 104 21 due due ADP admet-2022 104 22 to to ADP admet-2022 104 23 its its PRON admet-2022 104 24 smaller small ADJ admet-2022 104 25 particle particle NOUN admet-2022 104 26 size size NOUN admet-2022 104 27 . . PUNCT admet-2022 105 1 dissolution dissolution NOUN admet-2022 105 2 rates rate NOUN admet-2022 105 3 of of ADP admet-2022 105 4 f f PROPN admet-2022 105 5 , , PUNCT admet-2022 105 6 l l PROPN admet-2022 105 7 and and CCONJ admet-2022 105 8 s s PROPN admet-2022 105 9 show show VERB admet-2022 105 10 a a DET admet-2022 105 11 significant significant ADJ admet-2022 105 12 difference difference NOUN admet-2022 105 13 , , PUNCT admet-2022 105 14 confirmed confirm VERB admet-2022 105 15 by by ADP admet-2022 105 16 the the DET admet-2022 105 17 similarity similarity NOUN admet-2022 105 18 factor factor NOUN admet-2022 105 19 ( ( PUNCT admet-2022 105 20 f2 f2 PROPN admet-2022 105 21 ) ) PUNCT admet-2022 105 22 between between ADP admet-2022 105 23 f f PROPN admet-2022 105 24 , , PUNCT admet-2022 105 25 l l PROPN admet-2022 105 26 and and CCONJ admet-2022 105 27 s s PROPN admet-2022 105 28 , , PUNCT admet-2022 105 29 which which PRON admet-2022 105 30 is be AUX admet-2022 105 31 100 100 NUM admet-2022 105 32 . . PUNCT admet-2022 105 33 time time NOUN admet-2022 105 34 , , PUNCT admet-2022 105 35 min min NOUN admet-2022 105 36 figure figure NOUN admet-2022 105 37 1 1 NUM admet-2022 105 38 . . PUNCT admet-2022 105 39 release release NOUN admet-2022 105 40 profiles profile NOUN admet-2022 105 41 of of ADP admet-2022 105 42 pure pure ADJ admet-2022 105 43 dox dox NOUN admet-2022 105 44 , , PUNCT admet-2022 105 45 nanosuspension nanosuspension NOUN admet-2022 105 46 , , PUNCT admet-2022 105 47 liquid liquid ADJ admet-2022 105 48 snedds snedd NOUN admet-2022 105 49 and and CCONJ admet-2022 105 50 solid solid ADJ admet-2022 105 51 snedds snedd NOUN admet-2022 105 52 in in ADP admet-2022 105 53 phosphate phosphate ADJ admet-2022 105 54 buffer buffer NOUN admet-2022 105 55 ( ( PUNCT admet-2022 105 56 ph ph NOUN admet-2022 105 57 6.8 6.8 NUM admet-2022 105 58 ) ) PUNCT admet-2022 105 59 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 105 60 a. a. NOUN admet-2022 105 61 z. z. PROPN admet-2022 105 62 g. g. PROPN admet-2022 105 63 al al PROPN admet-2022 105 64 ashmawy ashmawy PROPN admet-2022 105 65 et et PROPN admet-2022 105 66 al al PROPN admet-2022 105 67 . . PROPN admet-2022 105 68 admet admet PROPN admet-2022 105 69 & & CCONJ admet-2022 105 70 dmpk dmpk PROPN admet-2022 105 71 12(1 12(1 PROPN admet-2022 105 72 ) ) PUNCT admet-2022 105 73 ( ( PUNCT admet-2022 105 74 2024 2024 NUM admet-2022 105 75 ) ) PUNCT admet-2022 105 76 167 167 NUM admet-2022 105 77 - - SYM admet-2022 105 78 176 176 NUM admet-2022 105 79 172 172 NUM admet-2022 105 80 characterization characterization NOUN admet-2022 105 81 of of ADP admet-2022 105 82 dox dox NOUN admet-2022 105 83 nanosuspension nanosuspension NOUN admet-2022 105 84 , , PUNCT admet-2022 105 85 liquid liquid ADJ admet-2022 105 86 and and CCONJ admet-2022 105 87 solid solid ADJ admet-2022 105 88 snedds snedd NOUN admet-2022 105 89 ( ( PUNCT admet-2022 105 90 f f X admet-2022 105 91 , , PUNCT admet-2022 105 92 l l PROPN admet-2022 105 93 and and CCONJ admet-2022 105 94 s s NOUN admet-2022 105 95 ) ) PUNCT admet-2022 105 96 using use VERB admet-2022 105 97 tem tem PROPN admet-2022 105 98 characterization characterization NOUN admet-2022 105 99 results result NOUN admet-2022 105 100 of of ADP admet-2022 105 101 all all DET admet-2022 105 102 dox dox NOUN admet-2022 105 103 formulations formulation NOUN admet-2022 105 104 revealed reveal VERB admet-2022 105 105 significant significant ADJ admet-2022 105 106 changes change NOUN admet-2022 105 107 in in ADP admet-2022 105 108 their their PRON admet-2022 105 109 shape shape NOUN admet-2022 105 110 , , PUNCT admet-2022 105 111 as as SCONJ admet-2022 105 112 shown show VERB admet-2022 105 113 in in ADP admet-2022 105 114 figure figure NOUN admet-2022 105 115 2b 2b NOUN admet-2022 105 116 , , PUNCT admet-2022 105 117 f f PROPN admet-2022 105 118 appearing appear VERB admet-2022 105 119 as as ADV admet-2022 105 120 discrete discrete ADJ admet-2022 105 121 particles particle NOUN admet-2022 105 122 [ [ X admet-2022 105 123 31 31 NUM admet-2022 105 124 ] ] PUNCT admet-2022 105 125 . . PUNCT admet-2022 106 1 on on ADP admet-2022 106 2 the the DET admet-2022 106 3 other other ADJ admet-2022 106 4 hand hand NOUN admet-2022 106 5 , , PUNCT admet-2022 106 6 comparing compare VERB admet-2022 106 7 the the DET admet-2022 106 8 tem tem NOUN admet-2022 106 9 of of ADP admet-2022 106 10 pure pure ADJ admet-2022 106 11 dox dox NOUN admet-2022 106 12 with with ADP admet-2022 106 13 the the DET admet-2022 106 14 tem tem PROPN admet-2022 106 15 of of ADP admet-2022 106 16 both both DET admet-2022 106 17 l l PROPN admet-2022 106 18 and and CCONJ admet-2022 106 19 s s PROPN admet-2022 106 20 ( ( PUNCT admet-2022 106 21 figures figure NOUN admet-2022 106 22 2a 2a NUM admet-2022 106 23 , , PUNCT admet-2022 106 24 2c 2c NOUN admet-2022 106 25 and and CCONJ admet-2022 106 26 2d 2d NOUN admet-2022 106 27 , , PUNCT admet-2022 106 28 respectively respectively ADV admet-2022 106 29 ) ) PUNCT admet-2022 106 30 , , PUNCT admet-2022 106 31 it it PRON admet-2022 106 32 was be AUX admet-2022 106 33 found find VERB admet-2022 106 34 that that SCONJ admet-2022 106 35 pure pure ADJ admet-2022 106 36 dox dox NOUN admet-2022 106 37 shape shape NOUN admet-2022 106 38 was be AUX admet-2022 106 39 changed change VERB admet-2022 106 40 in in ADP admet-2022 106 41 both both DET admet-2022 106 42 c c PROPN admet-2022 106 43 and and CCONJ admet-2022 106 44 d d X admet-2022 106 45 with with ADP admet-2022 106 46 smaller small ADJ admet-2022 106 47 particle particle NOUN admet-2022 106 48 size size NOUN admet-2022 106 49 in in ADP admet-2022 106 50 d d PROPN admet-2022 106 51 , , PUNCT admet-2022 106 52 confirming confirm VERB admet-2022 106 53 by by ADP admet-2022 106 54 particle particle NOUN admet-2022 106 55 size size NOUN admet-2022 106 56 results result NOUN admet-2022 106 57 [ [ X admet-2022 106 58 32 32 NUM admet-2022 106 59 ] ] PUNCT admet-2022 106 60 . . PUNCT admet-2022 107 1 a a DET admet-2022 107 2 b b X admet-2022 107 3 c c NOUN admet-2022 107 4 d d NOUN admet-2022 107 5 figure figure NOUN admet-2022 107 6 2 2 NUM admet-2022 107 7 . . X admet-2022 107 8 tem tem PROPN admet-2022 107 9 of of ADP admet-2022 107 10 ( ( PUNCT admet-2022 107 11 a a X admet-2022 107 12 ) ) PUNCT admet-2022 107 13 pure pure ADJ admet-2022 107 14 dox dox NOUN admet-2022 107 15 , , PUNCT admet-2022 107 16 ( ( PUNCT admet-2022 107 17 b b NOUN admet-2022 107 18 ) ) PUNCT admet-2022 107 19 nanosuspension nanosuspension NOUN admet-2022 107 20 , , PUNCT admet-2022 107 21 ( ( PUNCT admet-2022 107 22 c c X admet-2022 107 23 ) ) PUNCT admet-2022 107 24 liquid liquid NOUN admet-2022 107 25 snedds snedds NOUN admet-2022 107 26 , , PUNCT admet-2022 107 27 ( ( PUNCT admet-2022 107 28 d d X admet-2022 107 29 ) ) PUNCT admet-2022 107 30 solid solid ADJ admet-2022 107 31 snedds snedds PROPN admet-2022 107 32 . . PUNCT admet-2022 107 33 characterization characterization NOUN admet-2022 107 34 of of ADP admet-2022 107 35 dox dox NOUN admet-2022 107 36 nanosuspension nanosuspension NOUN admet-2022 107 37 , , PUNCT admet-2022 107 38 liquid liquid ADJ admet-2022 107 39 and and CCONJ admet-2022 107 40 solid solid ADJ admet-2022 107 41 snedds snedd NOUN admet-2022 107 42 using use VERB admet-2022 107 43 ftir ftir PROPN admet-2022 107 44 figure figure NOUN admet-2022 107 45 3 3 NUM admet-2022 107 46 shows show VERB admet-2022 107 47 the the DET admet-2022 107 48 ir ir PROPN admet-2022 107 49 spectrum spectrum NOUN admet-2022 107 50 of of ADP admet-2022 107 51 pure pure ADJ admet-2022 107 52 dox dox NOUN admet-2022 107 53 , , PUNCT admet-2022 107 54 f f PROPN admet-2022 107 55 , , PUNCT admet-2022 107 56 l l PROPN admet-2022 107 57 and and CCONJ admet-2022 107 58 s. s. PROPN admet-2022 107 59 table table NOUN admet-2022 107 60 3 3 NUM admet-2022 107 61 shows show VERB admet-2022 107 62 the the DET admet-2022 107 63 characteristic characteristic ADJ admet-2022 107 64 peak peak NOUN admet-2022 107 65 of of ADP admet-2022 107 66 pure pure ADJ admet-2022 107 67 dox dox NOUN admet-2022 107 68 ( ( PUNCT admet-2022 107 69 3180 3180 NUM admet-2022 107 70 cm-1 cm-1 NOUN admet-2022 107 71 ) ) PUNCT admet-2022 107 72 , , PUNCT admet-2022 107 73 which which PRON admet-2022 107 74 reflects reflect VERB admet-2022 107 75 the the DET admet-2022 107 76 presence presence NOUN admet-2022 107 77 of of ADP admet-2022 107 78 the the DET admet-2022 107 79 nh2 nh2 PROPN admet-2022 107 80 group group NOUN admet-2022 107 81 , , PUNCT admet-2022 107 82 shifted shift VERB admet-2022 107 83 in in ADP admet-2022 107 84 nanosuspension nanosuspension NOUN admet-2022 107 85 to to ADP admet-2022 107 86 3224 3224 NUM admet-2022 107 87 cm-1 cm-1 NOUN admet-2022 107 88 . . PUNCT admet-2022 108 1 another another DET admet-2022 108 2 peak peak NOUN admet-2022 108 3 in in ADP admet-2022 108 4 pure pure ADJ admet-2022 108 5 dox dox NOUN admet-2022 108 6 at at ADP admet-2022 108 7 1651 1651 NUM admet-2022 108 8 cm-1 cm-1 NOUN admet-2022 108 9 , , PUNCT admet-2022 108 10 reflecting reflect VERB admet-2022 108 11 the the DET admet-2022 108 12 c c PROPN admet-2022 108 13 = = NOUN admet-2022 108 14 o o NOUN admet-2022 108 15 group group NOUN admet-2022 108 16 , , PUNCT admet-2022 108 17 was be AUX admet-2022 108 18 shifted shift VERB admet-2022 108 19 in in ADP admet-2022 108 20 nanosuspension nanosuspension NOUN admet-2022 108 21 to to ADP admet-2022 108 22 1642 1642 NUM admet-2022 108 23 cm-1 cm-1 NOUN admet-2022 108 24 . . PUNCT admet-2022 109 1 the the DET admet-2022 109 2 peak peak NOUN admet-2022 109 3 at at ADP admet-2022 109 4 position position NOUN admet-2022 109 5 1591 1591 NUM admet-2022 109 6 cm-1 cm-1 PROPN admet-2022 109 7 , , PUNCT admet-2022 109 8 corresponding correspond VERB admet-2022 109 9 to to ADP admet-2022 109 10 the the DET admet-2022 109 11 c c PROPN admet-2022 109 12 = = PROPN admet-2022 109 13 n n PRON admet-2022 109 14 group group NOUN admet-2022 109 15 , , PUNCT admet-2022 109 16 was be AUX admet-2022 109 17 shifted shift VERB admet-2022 109 18 in in ADP admet-2022 109 19 nanosuspension nanosuspension NOUN admet-2022 109 20 to to ADP admet-2022 109 21 1600 1600 NUM admet-2022 109 22 cm-1 cm-1 NOUN admet-2022 109 23 . . PUNCT admet-2022 110 1 figure figure NOUN admet-2022 110 2 3 3 NUM admet-2022 110 3 . . PUNCT admet-2022 110 4 ftir ftir PROPN admet-2022 110 5 spectra spectra PROPN admet-2022 110 6 of of ADP admet-2022 110 7 ( ( PUNCT admet-2022 110 8 a a X admet-2022 110 9 ) ) PUNCT admet-2022 110 10 pure pure ADJ admet-2022 110 11 dox dox NOUN admet-2022 110 12 , , PUNCT admet-2022 110 13 ( ( PUNCT admet-2022 110 14 b b NOUN admet-2022 110 15 ) ) PUNCT admet-2022 110 16 nanosuspension nanosuspension NOUN admet-2022 110 17 , , PUNCT admet-2022 110 18 ( ( PUNCT admet-2022 110 19 c c X admet-2022 110 20 ) ) PUNCT admet-2022 110 21 liquid liquid NOUN admet-2022 110 22 snedds snedd NOUN admet-2022 110 23 and and CCONJ admet-2022 110 24 ( ( PUNCT admet-2022 110 25 d d NOUN admet-2022 110 26 ) ) PUNCT admet-2022 110 27 solid solid ADJ admet-2022 110 28 snedds snedds PROPN admet-2022 111 1 . . PUNCT admet-2022 111 2 admet admet PROPN admet-2022 111 3 & & CCONJ admet-2022 111 4 dmpk dmpk PROPN admet-2022 111 5 12(1 12(1 PROPN admet-2022 111 6 ) ) PUNCT admet-2022 111 7 ( ( PUNCT admet-2022 111 8 2024 2024 NUM admet-2022 111 9 ) ) PUNCT admet-2022 111 10 167 167 NUM admet-2022 111 11 - - SYM admet-2022 111 12 176 176 NUM admet-2022 111 13 nanosuspension nanosuspension NOUN admet-2022 111 14 versus versus ADP admet-2022 111 15 self self NOUN admet-2022 111 16 - - PUNCT admet-2022 111 17 nanoemulsifying nanoemulsifye VERB admet-2022 111 18 drug drug NOUN admet-2022 111 19 delivery delivery NOUN admet-2022 111 20 doi doi NOUN admet-2022 111 21 : : PUNCT admet-2022 111 22 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 111 23 173 173 NUM admet-2022 111 24 regarding regard VERB admet-2022 111 25 the the DET admet-2022 111 26 ir ir PROPN admet-2022 111 27 spectra spectra NOUN admet-2022 111 28 of of ADP admet-2022 111 29 liquid liquid ADJ admet-2022 111 30 and and CCONJ admet-2022 111 31 solid solid ADJ admet-2022 111 32 snedds snedd NOUN admet-2022 111 33 , , PUNCT admet-2022 111 34 the the DET admet-2022 111 35 disappearance disappearance NOUN admet-2022 111 36 of of ADP admet-2022 111 37 the the DET admet-2022 111 38 characteristic characteristic ADJ admet-2022 111 39 peaks peak NOUN admet-2022 111 40 of of ADP admet-2022 111 41 dox dox NOUN admet-2022 111 42 reflecting reflect VERB admet-2022 111 43 nh2 nh2 PROPN admet-2022 111 44 group group NOUN admet-2022 111 45 was be AUX admet-2022 111 46 observed observe VERB admet-2022 111 47 , , PUNCT admet-2022 111 48 suggesting suggest VERB admet-2022 111 49 the the DET admet-2022 111 50 protonation protonation NOUN admet-2022 111 51 of of ADP admet-2022 111 52 the the DET admet-2022 111 53 nh2 nh2 PROPN admet-2022 111 54 group group NOUN admet-2022 111 55 of of ADP admet-2022 111 56 dox dox NOUN admet-2022 111 57 forming form VERB admet-2022 111 58 ion ion NOUN admet-2022 111 59 pair pair NOUN admet-2022 111 60 with with ADP admet-2022 111 61 ionized ionized ADJ admet-2022 111 62 -cooh -cooh ADJ admet-2022 111 63 group group NOUN admet-2022 111 64 of of ADP admet-2022 111 65 oleic oleic ADJ admet-2022 111 66 acid acid PROPN admet-2022 111 67 . . PUNCT admet-2022 112 1 the the DET admet-2022 112 2 peak peak NOUN admet-2022 112 3 of of ADP admet-2022 112 4 the the DET admet-2022 112 5 c c PROPN admet-2022 112 6 = = NOUN admet-2022 112 7 n n PROPN admet-2022 112 8 group group NOUN admet-2022 112 9 at at ADP admet-2022 112 10 1651 1651 NUM admet-2022 112 11 cm-1 cm-1 VERB admet-2022 112 12 was be AUX admet-2022 112 13 shifted shift VERB admet-2022 112 14 to to ADP admet-2022 112 15 1644 1644 NUM admet-2022 112 16 and and CCONJ admet-2022 112 17 1631 1631 NUM admet-2022 112 18 cm1 cm1 NOUN admet-2022 112 19 in in ADP admet-2022 112 20 liquid liquid ADJ admet-2022 112 21 and and CCONJ admet-2022 112 22 solid solid ADJ admet-2022 112 23 snedds snedds PROPN admet-2022 112 24 , , PUNCT admet-2022 112 25 respectively respectively ADV admet-2022 112 26 . . PUNCT admet-2022 113 1 another another DET admet-2022 113 2 peak peak NOUN admet-2022 113 3 at at ADP admet-2022 113 4 1039 1039 NUM admet-2022 113 5 cm-1 cm-1 NOUN admet-2022 113 6 corresponding correspond VERB admet-2022 113 7 to to ADP admet-2022 113 8 the the DET admet-2022 113 9 c c PROPN admet-2022 113 10 - - PUNCT admet-2022 113 11 o o PROPN admet-2022 113 12 group group NOUN admet-2022 113 13 was be AUX admet-2022 113 14 shifted shift VERB admet-2022 113 15 to to ADP admet-2022 113 16 1248 1248 NUM admet-2022 113 17 cm-1 cm-1 VERB admet-2022 113 18 in in ADP admet-2022 113 19 both both CCONJ admet-2022 113 20 liquid liquid ADJ admet-2022 113 21 and and CCONJ admet-2022 113 22 solid solid ADJ admet-2022 113 23 snedds snedd NOUN admet-2022 113 24 . . PUNCT admet-2022 114 1 the the DET admet-2022 114 2 final final ADJ admet-2022 114 3 peak peak NOUN admet-2022 114 4 for for ADP admet-2022 114 5 the the DET admet-2022 114 6 c c PROPN admet-2022 114 7 = = PROPN admet-2022 114 8 c c PROPN admet-2022 114 9 group group NOUN admet-2022 114 10 of of ADP admet-2022 114 11 dox dox NOUN admet-2022 114 12 appearing appear VERB admet-2022 114 13 in in ADP admet-2022 114 14 1490 1490 NUM admet-2022 114 15 cm-1 cm-1 NOUN admet-2022 114 16 was be AUX admet-2022 114 17 shifted shift VERB admet-2022 114 18 to to ADP admet-2022 114 19 1460 1460 NUM admet-2022 114 20 cm-1 cm-1 VERB admet-2022 114 21 in in ADP admet-2022 114 22 both both CCONJ admet-2022 114 23 liquid liquid ADJ admet-2022 114 24 and and CCONJ admet-2022 114 25 solid solid ADJ admet-2022 114 26 snedds snedd NOUN admet-2022 114 27 . . PUNCT admet-2022 115 1 those those DET admet-2022 115 2 changes change NOUN admet-2022 115 3 confirm confirm VERB admet-2022 115 4 the the DET admet-2022 115 5 presence presence NOUN admet-2022 115 6 of of ADP admet-2022 115 7 liquid liquid ADJ admet-2022 115 8 and and CCONJ admet-2022 115 9 solid solid ADJ admet-2022 115 10 snedds snedd NOUN admet-2022 115 11 , , PUNCT admet-2022 115 12 as as SCONJ admet-2022 115 13 illustrated illustrate VERB admet-2022 115 14 previously previously ADV admet-2022 115 15 [ [ X admet-2022 115 16 20 20 NUM admet-2022 115 17 ] ] PUNCT admet-2022 115 18 . . PUNCT admet-2022 116 1 the the DET admet-2022 116 2 particle particle NOUN admet-2022 116 3 size size NOUN admet-2022 116 4 of of ADP admet-2022 116 5 solid solid ADJ admet-2022 116 6 snedds snedd NOUN admet-2022 116 7 is be AUX admet-2022 116 8 less less ADJ admet-2022 116 9 than than ADP admet-2022 116 10 the the DET admet-2022 116 11 droplet droplet ADJ admet-2022 116 12 size size NOUN admet-2022 116 13 of of ADP admet-2022 116 14 liquid liquid NOUN admet-2022 116 15 snedds snedd NOUN admet-2022 116 16 due due ADP admet-2022 116 17 to to ADP admet-2022 116 18 the the DET admet-2022 116 19 formation formation NOUN admet-2022 116 20 of of ADP admet-2022 116 21 hydrogen hydrogen NOUN admet-2022 116 22 bonding bonding NOUN admet-2022 116 23 between between ADP admet-2022 116 24 the the DET admet-2022 116 25 snedds snedds PROPN admet-2022 116 26 and and CCONJ admet-2022 116 27 -oh -oh ADJ admet-2022 116 28 group group NOUN admet-2022 116 29 of of ADP admet-2022 116 30 the the DET admet-2022 116 31 adsorbent adsorbent NOUN admet-2022 116 32 mixture mixture NOUN admet-2022 116 33 ( ( PUNCT admet-2022 116 34 aerosil aerosil NOUN admet-2022 116 35 200 200 NUM admet-2022 116 36 and and CCONJ admet-2022 116 37 avicel avicel VERB admet-2022 116 38 101 101 NUM admet-2022 116 39 ) ) PUNCT admet-2022 117 1 [ [ X admet-2022 117 2 20 20 NUM admet-2022 117 3 ] ] PUNCT admet-2022 117 4 . . PUNCT admet-2022 118 1 table table NOUN admet-2022 118 2 3 3 NUM admet-2022 118 3 . . PUNCT admet-2022 118 4 functional functional ADJ admet-2022 118 5 groups group NOUN admet-2022 118 6 of of ADP admet-2022 118 7 ftir ftir PROPN admet-2022 118 8 spectra spectra PROPN admet-2022 118 9 group group PROPN admet-2022 118 10 wavenumber wavenumber NOUN admet-2022 118 11 , , PUNCT admet-2022 118 12 cm cm NOUN admet-2022 118 13 -1 -1 ADP admet-2022 118 14 pure pure ADJ admet-2022 118 15 dox dox NOUN admet-2022 118 16 f f PROPN admet-2022 118 17 l l NOUN admet-2022 118 18 s s VERB admet-2022 118 19 nh2 nh2 NOUN admet-2022 118 20 3180 3180 NUM admet-2022 118 21 3224 3224 NUM admet-2022 118 22 c c X admet-2022 118 23 = = SYM admet-2022 118 24 o o NOUN admet-2022 118 25 164 164 NUM admet-2022 118 26 1642 1642 NUM admet-2022 118 27 c c NOUN admet-2022 118 28 - - PUNCT admet-2022 118 29 o o NOUN admet-2022 118 30 1039 1039 NUM admet-2022 118 31 1248 1248 NUM admet-2022 118 32 1248 1248 NUM admet-2022 118 33 c c X admet-2022 118 34 = = SYM admet-2022 118 35 n n PROPN admet-2022 118 36 1591 1591 NUM admet-2022 118 37 1600 1600 NUM admet-2022 118 38 1644 1644 NUM admet-2022 118 39 1631 1631 NUM admet-2022 119 1 c c X admet-2022 119 2 = = SYM admet-2022 119 3 c c NOUN admet-2022 119 4 1490 1490 NUM admet-2022 119 5 1460 1460 NUM admet-2022 119 6 1460 1460 NUM admet-2022 119 7 in in ADP admet-2022 119 8 vivo vivo ADJ admet-2022 119 9 evaluation evaluation NOUN admet-2022 119 10 of of ADP admet-2022 119 11 dox dox NOUN admet-2022 119 12 nanosuspension nanosuspension NOUN admet-2022 119 13 , , PUNCT admet-2022 119 14 liquid liquid ADJ admet-2022 119 15 and and CCONJ admet-2022 119 16 solid solid ADJ admet-2022 119 17 snedds snedd NOUN admet-2022 119 18 ( ( PUNCT admet-2022 119 19 f f X admet-2022 119 20 , , PUNCT admet-2022 119 21 l l PROPN admet-2022 119 22 and and CCONJ admet-2022 119 23 s s NOUN admet-2022 119 24 ) ) PUNCT admet-2022 119 25 induction induction NOUN admet-2022 119 26 of of ADP admet-2022 119 27 hypertension hypertension NOUN admet-2022 119 28 in in ADP admet-2022 119 29 rats rat NOUN admet-2022 119 30 resulted result VERB admet-2022 119 31 in in ADP admet-2022 119 32 a a DET admet-2022 119 33 highly highly ADV admet-2022 119 34 significant significant ADJ admet-2022 119 35 ( ( PUNCT admet-2022 119 36 p p NOUN admet-2022 119 37 = = NOUN admet-2022 119 38 0.00 0.00 NUM admet-2022 119 39 ) ) PUNCT admet-2022 119 40 increase increase NOUN admet-2022 119 41 in in ADP admet-2022 119 42 their their PRON admet-2022 119 43 mean mean ADJ admet-2022 119 44 arterial arterial ADJ admet-2022 119 45 blood blood NOUN admet-2022 119 46 pressure pressure NOUN admet-2022 119 47 ( ( PUNCT admet-2022 119 48 map map NOUN admet-2022 119 49 ) ) PUNCT admet-2022 119 50 . . PUNCT admet-2022 120 1 similar similar ADJ admet-2022 120 2 results result NOUN admet-2022 120 3 were be AUX admet-2022 120 4 reported report VERB admet-2022 120 5 by by ADP admet-2022 120 6 wei wei PROPN admet-2022 120 7 et et PROPN admet-2022 120 8 al al PROPN admet-2022 120 9 . . PUNCT admet-2022 121 1 [ [ X admet-2022 121 2 33 33 NUM admet-2022 121 3 ] ] PUNCT admet-2022 121 4 . . PUNCT admet-2022 122 1 comparing compare VERB admet-2022 122 2 the the DET admet-2022 122 3 effectiveness effectiveness NOUN admet-2022 122 4 of of ADP admet-2022 122 5 dox dox NOUN admet-2022 122 6 lyophilized lyophilize VERB admet-2022 122 7 nanosuspension nanosuspension NOUN admet-2022 122 8 ( ( PUNCT admet-2022 122 9 group group NOUN admet-2022 122 10 ii ii PROPN admet-2022 122 11 ) ) PUNCT admet-2022 122 12 with with ADP admet-2022 122 13 market market NOUN admet-2022 122 14 tablet tablet NOUN admet-2022 122 15 dosin dosin NOUN admet-2022 122 16 ® ® NOUN admet-2022 122 17 ( ( PUNCT admet-2022 122 18 group group NOUN admet-2022 122 19 i i PROPN admet-2022 122 20 ) ) PUNCT admet-2022 122 21 , , PUNCT admet-2022 122 22 it it PRON admet-2022 122 23 is be AUX admet-2022 122 24 clear clear ADJ admet-2022 122 25 that that SCONJ admet-2022 122 26 there there PRON admet-2022 122 27 was be VERB admet-2022 122 28 a a DET admet-2022 122 29 significant significant ADJ admet-2022 122 30 ( ( PUNCT admet-2022 122 31 p p X admet-2022 122 32 = = NOUN admet-2022 122 33 0.016 0.016 NUM admet-2022 122 34 ) ) PUNCT admet-2022 122 35 difference difference NOUN admet-2022 122 36 in in ADP admet-2022 122 37 the the DET admet-2022 122 38 map map NOUN admet-2022 122 39 of of ADP admet-2022 122 40 rats rat NOUN admet-2022 122 41 of of ADP admet-2022 122 42 both both DET admet-2022 122 43 groups group NOUN admet-2022 122 44 . . PUNCT admet-2022 123 1 also also ADV admet-2022 123 2 , , PUNCT admet-2022 123 3 on on ADP admet-2022 123 4 comparing compare VERB admet-2022 123 5 rat rat NOUN admet-2022 123 6 groups group NOUN admet-2022 123 7 treated treat VERB admet-2022 123 8 with with ADP admet-2022 123 9 either either CCONJ admet-2022 123 10 market market NOUN admet-2022 123 11 tablet tablet NOUN admet-2022 123 12 dosin dosin PROPN admet-2022 123 13 ® ® PROPN admet-2022 123 14 , , PUNCT admet-2022 123 15 l l PROPN admet-2022 123 16 or or CCONJ admet-2022 123 17 s s X admet-2022 123 18 ( ( PUNCT admet-2022 123 19 groups group NOUN admet-2022 123 20 i i PRON admet-2022 123 21 , , PUNCT admet-2022 123 22 iii iii PROPN admet-2022 123 23 and and CCONJ admet-2022 123 24 iv iv NUM admet-2022 123 25 respectively respectively ADV admet-2022 123 26 ) ) PUNCT admet-2022 123 27 , , PUNCT admet-2022 123 28 they they PRON admet-2022 123 29 showed show VERB admet-2022 123 30 significant significant ADJ admet-2022 123 31 ( ( PUNCT admet-2022 123 32 p p NOUN admet-2022 123 33 = = NOUN admet-2022 123 34 0.00 0.00 NUM admet-2022 123 35 ) ) PUNCT admet-2022 123 36 reduction reduction NOUN admet-2022 123 37 in in ADP admet-2022 123 38 map map NOUN admet-2022 123 39 compared compare VERB admet-2022 123 40 to to ADP admet-2022 123 41 the the DET admet-2022 123 42 hypertensive hypertensive ADJ admet-2022 123 43 non non ADJ admet-2022 123 44 - - ADJ admet-2022 123 45 treated treat VERB admet-2022 123 46 rats rat NOUN admet-2022 123 47 ( ( PUNCT admet-2022 123 48 group group NOUN admet-2022 123 49 v v NOUN admet-2022 123 50 ) ) PUNCT admet-2022 123 51 ( ( PUNCT admet-2022 123 52 table table NOUN admet-2022 123 53 4 4 NUM admet-2022 123 54 and and CCONJ admet-2022 123 55 figure figure VERB admet-2022 123 56 4 4 NUM admet-2022 123 57 ) ) PUNCT admet-2022 123 58 . . PUNCT admet-2022 124 1 dosin dosin NOUN admet-2022 124 2 ® ® NOUN admet-2022 124 3 was be AUX admet-2022 124 4 able able ADJ admet-2022 124 5 to to PART admet-2022 124 6 decrease decrease VERB admet-2022 124 7 the the DET admet-2022 124 8 map map NOUN admet-2022 124 9 of of ADP admet-2022 124 10 hypertensive hypertensive ADJ admet-2022 124 11 rats rat NOUN admet-2022 124 12 to to ADP admet-2022 124 13 normal normal ADJ admet-2022 124 14 values value NOUN admet-2022 124 15 ( ( PUNCT admet-2022 124 16 group group NOUN admet-2022 124 17 i i PROPN admet-2022 124 18 ) ) PUNCT admet-2022 124 19 for for ADP admet-2022 124 20 only only ADV admet-2022 124 21 15 15 NUM admet-2022 124 22 min min NOUN admet-2022 124 23 , , PUNCT admet-2022 124 24 followed follow VERB admet-2022 124 25 by by ADP admet-2022 124 26 a a DET admet-2022 124 27 re re NOUN admet-2022 124 28 - - NOUN admet-2022 124 29 increase increase VERB admet-2022 124 30 in in ADP admet-2022 124 31 map map NOUN admet-2022 124 32 . . PUNCT admet-2022 125 1 on on ADP admet-2022 125 2 the the DET admet-2022 125 3 contrary contrary NOUN admet-2022 125 4 , , PUNCT admet-2022 125 5 f f PROPN admet-2022 125 6 ( ( PUNCT admet-2022 125 7 dox dox NOUN admet-2022 125 8 lyophilized lyophilize VERB admet-2022 125 9 nanosuspension nanosuspension NOUN admet-2022 125 10 ) ) PUNCT admet-2022 125 11 , , PUNCT admet-2022 125 12 l l NOUN admet-2022 125 13 and and CCONJ admet-2022 125 14 s s VERB admet-2022 125 15 showed show VERB admet-2022 125 16 a a DET admet-2022 125 17 decrease decrease NOUN admet-2022 125 18 in in ADP admet-2022 125 19 map map NOUN admet-2022 125 20 of of ADP admet-2022 125 21 hypertensive hypertensive ADJ admet-2022 125 22 rats rat NOUN admet-2022 125 23 ( ( PUNCT admet-2022 125 24 group group NOUN admet-2022 125 25 ii ii PROPN admet-2022 125 26 , , PUNCT admet-2022 125 27 iii iii PROPN admet-2022 125 28 and and CCONJ admet-2022 125 29 iv iv X admet-2022 125 30 ) ) PUNCT admet-2022 125 31 to to ADP admet-2022 125 32 normal normal ADJ admet-2022 125 33 values value NOUN admet-2022 125 34 for for ADP admet-2022 125 35 more more ADJ admet-2022 125 36 than than ADP admet-2022 125 37 180 180 NUM admet-2022 125 38 min min NOUN admet-2022 125 39 . . NOUN admet-2022 125 40 liquid liquid ADJ admet-2022 125 41 and and CCONJ admet-2022 125 42 solid solid ADJ admet-2022 125 43 snedds snedd NOUN admet-2022 125 44 showed show VERB admet-2022 125 45 a a DET admet-2022 125 46 higher high ADJ admet-2022 125 47 decrease decrease NOUN admet-2022 125 48 in in ADP admet-2022 125 49 map map NOUN admet-2022 125 50 than than ADP admet-2022 125 51 the the DET admet-2022 125 52 nanosuspension nanosuspension NOUN admet-2022 125 53 owing owe VERB admet-2022 125 54 to to ADP admet-2022 125 55 the the DET admet-2022 125 56 use use NOUN admet-2022 125 57 of of ADP admet-2022 125 58 tween tween NOUN admet-2022 125 59 80 80 NUM admet-2022 125 60 ( ( PUNCT admet-2022 125 61 surfactant surfactant NOUN admet-2022 125 62 ) ) PUNCT admet-2022 125 63 , , PUNCT admet-2022 125 64 which which PRON admet-2022 125 65 has have VERB admet-2022 125 66 a a DET admet-2022 125 67 high high ADJ admet-2022 125 68 hlb hlb NOUN admet-2022 125 69 value value NOUN admet-2022 125 70 and and CCONJ admet-2022 125 71 creates create VERB admet-2022 125 72 micelle micelle NOUN admet-2022 125 73 structures structure NOUN admet-2022 125 74 that that PRON admet-2022 125 75 entrap entrap VERB admet-2022 125 76 dox dox NOUN admet-2022 125 77 and and CCONJ admet-2022 125 78 improve improve VERB admet-2022 125 79 its its PRON admet-2022 125 80 solubility solubility NOUN admet-2022 125 81 . . PUNCT admet-2022 126 1 however however ADV admet-2022 126 2 , , PUNCT admet-2022 126 3 the the DET admet-2022 126 4 effect effect NOUN admet-2022 126 5 of of ADP admet-2022 126 6 solid solid ADJ admet-2022 126 7 snedds snedd NOUN admet-2022 126 8 on on ADP admet-2022 126 9 map map NOUN admet-2022 126 10 reduction reduction NOUN admet-2022 126 11 was be AUX admet-2022 126 12 superior superior ADJ admet-2022 126 13 ( ( PUNCT admet-2022 126 14 p p X admet-2022 126 15 < < X admet-2022 126 16 0.05 0.05 NUM admet-2022 126 17 ) ) PUNCT admet-2022 126 18 to to ADP admet-2022 126 19 both both CCONJ admet-2022 126 20 liquid liquid ADJ admet-2022 126 21 snedds snedd NOUN admet-2022 126 22 and and CCONJ admet-2022 126 23 lyophilized lyophilized ADJ admet-2022 126 24 nanosuspension nanosuspension NOUN admet-2022 126 25 . . PUNCT admet-2022 127 1 there there PRON admet-2022 127 2 are be VERB admet-2022 127 3 statistically statistically ADV admet-2022 127 4 significant significant ADJ admet-2022 127 5 differences difference NOUN admet-2022 127 6 between between ADP admet-2022 127 7 the the DET admet-2022 127 8 map map NOUN admet-2022 127 9 of of ADP admet-2022 127 10 rats rat NOUN admet-2022 127 11 in in ADP admet-2022 127 12 the the DET admet-2022 127 13 untreated untreated ADJ admet-2022 127 14 control control PROPN admet-2022 127 15 group group NOUN admet-2022 127 16 ( ( PUNCT admet-2022 127 17 group group NOUN admet-2022 127 18 v v NOUN admet-2022 127 19 ) ) PUNCT admet-2022 127 20 and and CCONJ admet-2022 127 21 the the DET admet-2022 127 22 map map NOUN admet-2022 127 23 of of ADP admet-2022 127 24 rats rat NOUN admet-2022 127 25 in in ADP admet-2022 127 26 groups group NOUN admet-2022 127 27 ( ( PUNCT admet-2022 127 28 ii ii PROPN admet-2022 127 29 , , PUNCT admet-2022 127 30 iii iii PROPN admet-2022 127 31 and and CCONJ admet-2022 127 32 iv iv NOUN admet-2022 127 33 ) ) PUNCT admet-2022 127 34 as as SCONJ admet-2022 127 35 shown show VERB admet-2022 127 36 in in ADP admet-2022 127 37 table table NOUN admet-2022 127 38 4 4 NUM admet-2022 127 39 . . PUNCT admet-2022 128 1 this this DET admet-2022 128 2 result result NOUN admet-2022 128 3 may may AUX admet-2022 128 4 be be AUX admet-2022 128 5 explained explain VERB admet-2022 128 6 on on ADP admet-2022 128 7 the the DET admet-2022 128 8 basis basis NOUN admet-2022 128 9 of of ADP admet-2022 128 10 the the DET admet-2022 128 11 difference difference NOUN admet-2022 128 12 in in ADP admet-2022 128 13 particle particle NOUN admet-2022 128 14 size size NOUN admet-2022 128 15 between between ADP admet-2022 128 16 the the DET admet-2022 128 17 three three NUM admet-2022 128 18 formulations formulation NOUN admet-2022 128 19 . . PUNCT admet-2022 129 1 table table NOUN admet-2022 129 2 4 4 NUM admet-2022 129 3 . . X admet-2022 129 4 map map NOUN admet-2022 129 5 of of ADP admet-2022 129 6 the the DET admet-2022 129 7 five five NUM admet-2022 129 8 rat rat NOUN admet-2022 129 9 groups group NOUN admet-2022 129 10 ( ( PUNCT admet-2022 129 11 n n NOUN admet-2022 129 12 = = SYM admet-2022 129 13 5 5 NUM admet-2022 129 14 ; ; PUNCT admet-2022 129 15 mean mean PROPN admet-2022 129 16 ± ± NUM admet-2022 129 17 sd sd NOUN admet-2022 129 18 ) ) PUNCT admet-2022 129 19 . . PUNCT admet-2022 130 1 time time NOUN admet-2022 130 2 , , PUNCT admet-2022 130 3 min min NOUN admet-2022 130 4 map map NOUN admet-2022 130 5 , , PUNCT admet-2022 130 6 kpa kpa PROPN admet-2022 130 7 group group PROPN admet-2022 130 8 i i PROPN admet-2022 130 9 group group PROPN admet-2022 130 10 ii ii PROPN admet-2022 130 11 group group PROPN admet-2022 130 12 iii iii PROPN admet-2022 130 13 group group PROPN admet-2022 130 14 iv iv NUM admet-2022 130 15 group group NOUN admet-2022 130 16 v v PROPN admet-2022 130 17 * * PROPN admet-2022 130 18 0 0 NUM admet-2022 130 19 143.66±083 143.66±083 NUM admet-2022 130 20 165.33±2.00 165.33±2.00 NUM admet-2022 130 21 158.33±3.51 158.33±3.51 NUM admet-2022 130 22 160.00±2.00 160.00±2.00 NUM admet-2022 130 23 141.00±2.45 141.00±2.45 NUM admet-2022 130 24 15 15 NUM admet-2022 130 25 134.33±1.90 134.33±1.90 NUM admet-2022 130 26 146.66±2.03 146.66±2.03 NUM admet-2022 130 27 146.33±4.72 146.33±4.72 NUM admet-2022 130 28 130.00±9.00 130.00±9.00 NUM admet-2022 130 29 135.33±2.54 135.33±2.54 NUM admet-2022 130 30 30 30 NUM admet-2022 130 31 142.00±6.83 142.00±6.83 NUM admet-2022 130 32 132.00±7.17 132.00±7.17 NUM admet-2022 130 33 135.00±5.77 135.00±5.77 NUM admet-2022 130 34 126.00±6.24 126.00±6.24 NUM admet-2022 130 35 144.33±3.39 144.33±3.39 NUM admet-2022 130 36 60 60 NUM admet-2022 130 37 147.00±1.84 147.00±1.84 NUM admet-2022 130 38 131.66±8.00 131.66±8.00 NUM admet-2022 130 39 122.00±6.00 122.00±6.00 NUM admet-2022 130 40 106.00±11.53 106.00±11.53 NUM admet-2022 130 41 145.33±5.52 145.33±5.52 NUM admet-2022 130 42 90 90 NUM admet-2022 130 43 153.33±2.00 153.33±2.00 NUM admet-2022 130 44 126.33±1.16 126.33±1.16 NUM admet-2022 130 45 120.33±1.52 120.33±1.52 NUM admet-2022 130 46 108.33±6.50 108.33±6.50 NUM admet-2022 130 47 145.00±2.21 145.00±2.21 NUM admet-2022 130 48 120 120 NUM admet-2022 130 49 152.00±1.53 152.00±1.53 NUM admet-2022 130 50 123.00±5.02 123.00±5.02 NUM admet-2022 130 51 120.66±0.57 120.66±0.57 NUM admet-2022 130 52 107.00±1.42 107.00±1.42 NUM admet-2022 130 53 146.00±2.87 146.00±2.87 NUM admet-2022 130 54 150 150 NUM admet-2022 130 55 150.00±1.67 150.00±1.67 NUM admet-2022 130 56 123.33±3.00 123.33±3.00 NUM admet-2022 130 57 118.00±1.73 118.00±1.73 NUM admet-2022 130 58 106.00±2.00 106.00±2.00 NUM admet-2022 130 59 141.66±2.03 141.66±2.03 NUM admet-2022 130 60 180 180 NUM admet-2022 130 61 151.66±2.03 151.66±2.03 NUM admet-2022 130 62 123.00±1.88 123.00±1.88 NUM admet-2022 130 63 118.33±2.08 118.33±2.08 NUM admet-2022 130 64 104.66±1.15 104.66±1.15 NUM admet-2022 130 65 141.66±1.07 141.66±1.07 NUM admet-2022 130 66 * * PUNCT admet-2022 130 67 significantly significantly ADV admet-2022 130 68 high high ADJ admet-2022 130 69 blood blood NOUN admet-2022 130 70 pressure pressure NOUN admet-2022 130 71 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 130 72 a. a. NOUN admet-2022 130 73 z. z. PROPN admet-2022 130 74 g. g. PROPN admet-2022 130 75 al al PROPN admet-2022 130 76 ashmawy ashmawy PROPN admet-2022 130 77 et et PROPN admet-2022 130 78 al al PROPN admet-2022 130 79 . . PROPN admet-2022 130 80 admet admet PROPN admet-2022 130 81 & & CCONJ admet-2022 130 82 dmpk dmpk PROPN admet-2022 130 83 12(1 12(1 PROPN admet-2022 130 84 ) ) PUNCT admet-2022 130 85 ( ( PUNCT admet-2022 130 86 2024 2024 NUM admet-2022 130 87 ) ) PUNCT admet-2022 130 88 167 167 NUM admet-2022 130 89 - - SYM admet-2022 130 90 176 176 NUM admet-2022 130 91 174 174 NUM admet-2022 130 92 figure figure NOUN admet-2022 130 93 4 4 NUM admet-2022 130 94 . . NOUN admet-2022 130 95 map map NOUN admet-2022 130 96 of of ADP admet-2022 130 97 five five NUM admet-2022 130 98 rat rat NOUN admet-2022 130 99 groups group NOUN admet-2022 130 100 . . PUNCT admet-2022 131 1 conclusions conclusion NOUN admet-2022 131 2 this this DET admet-2022 131 3 study study NOUN admet-2022 131 4 demonstrated demonstrate VERB admet-2022 131 5 the the DET admet-2022 131 6 effectiveness effectiveness NOUN admet-2022 131 7 of of ADP admet-2022 131 8 applied apply VERB admet-2022 131 9 techniques technique NOUN admet-2022 131 10 in in ADP admet-2022 131 11 the the DET admet-2022 131 12 preparation preparation NOUN admet-2022 131 13 of of ADP admet-2022 131 14 the the DET admet-2022 131 15 nano nano NOUN admet-2022 131 16 formula formula NOUN admet-2022 131 17 of of ADP admet-2022 131 18 doxazosin doxazosin PROPN admet-2022 131 19 mesylate mesylate NOUN admet-2022 131 20 . . PUNCT admet-2022 132 1 from from ADP admet-2022 132 2 the the DET admet-2022 132 3 above above ADJ admet-2022 132 4 results result NOUN admet-2022 132 5 , , PUNCT admet-2022 132 6 it it PRON admet-2022 132 7 is be AUX admet-2022 132 8 clear clear ADJ admet-2022 132 9 that that SCONJ admet-2022 132 10 the the DET admet-2022 132 11 incorporation incorporation NOUN admet-2022 132 12 of of ADP admet-2022 132 13 dox dox NOUN admet-2022 132 14 in in ADP admet-2022 132 15 nano nano NOUN admet-2022 132 16 - - PUNCT admet-2022 132 17 suspension suspension NOUN admet-2022 132 18 and and CCONJ admet-2022 132 19 sedds sedd NOUN admet-2022 132 20 in in ADP admet-2022 132 21 liquid liquid ADJ admet-2022 132 22 and and CCONJ admet-2022 132 23 solid solid ADJ admet-2022 132 24 form form NOUN admet-2022 132 25 leads lead VERB admet-2022 132 26 to to ADP admet-2022 132 27 an an DET admet-2022 132 28 increase increase NOUN admet-2022 132 29 in in ADP admet-2022 132 30 surface surface NOUN admet-2022 132 31 area area NOUN admet-2022 132 32 , , PUNCT admet-2022 132 33 drug drug NOUN admet-2022 132 34 ’s ’s PART admet-2022 132 35 solubility solubility NOUN admet-2022 132 36 and and CCONJ admet-2022 132 37 release release NOUN admet-2022 132 38 rate rate NOUN admet-2022 132 39 of of ADP admet-2022 132 40 dox dox NOUN admet-2022 132 41 compared compare VERB admet-2022 132 42 to to ADP admet-2022 132 43 the the DET admet-2022 132 44 pure pure ADJ admet-2022 132 45 drug drug NOUN admet-2022 132 46 . . PUNCT admet-2022 133 1 incorporation incorporation NOUN admet-2022 133 2 of of ADP admet-2022 133 3 dox dox NOUN admet-2022 133 4 in in ADP admet-2022 133 5 solid solid ADJ admet-2022 133 6 snedds snedd NOUN admet-2022 133 7 , , PUNCT admet-2022 133 8 liquid liquid ADJ admet-2022 133 9 snedds snedd NOUN admet-2022 133 10 and and CCONJ admet-2022 133 11 nanosuspension nanosuspension NOUN admet-2022 133 12 led lead VERB admet-2022 133 13 to to ADP admet-2022 133 14 a a DET admet-2022 133 15 significant significant ADJ admet-2022 133 16 reduction reduction NOUN admet-2022 133 17 in in ADP admet-2022 133 18 map map NOUN admet-2022 133 19 of of ADP admet-2022 133 20 hypertensive hypertensive ADJ admet-2022 133 21 rats rat NOUN admet-2022 133 22 for for ADP admet-2022 133 23 more more ADJ admet-2022 133 24 than than ADP admet-2022 133 25 180 180 NUM admet-2022 133 26 min min NOUN admet-2022 133 27 when when SCONJ admet-2022 133 28 compared compare VERB admet-2022 133 29 with with ADP admet-2022 133 30 the the DET admet-2022 133 31 marketed market VERB admet-2022 133 32 tablet tablet NOUN admet-2022 133 33 ( ( PUNCT admet-2022 133 34 dosin dosin NOUN admet-2022 133 35 ® ® PROPN admet-2022 133 36 ) ) PUNCT admet-2022 133 37 . . PUNCT admet-2022 134 1 acknowledgements acknowledgement NOUN admet-2022 134 2 : : PUNCT admet-2022 134 3 the the DET admet-2022 134 4 authors author NOUN admet-2022 134 5 are be AUX admet-2022 134 6 thankful thankful ADJ admet-2022 134 7 to to ADP admet-2022 134 8 the the DET admet-2022 134 9 deanship deanship NOUN admet-2022 134 10 of of ADP admet-2022 134 11 scientific scientific ADJ admet-2022 134 12 research research NOUN admet-2022 134 13 at at ADP admet-2022 134 14 najran najran ADJ admet-2022 134 15 university university PROPN admet-2022 134 16 for for ADP admet-2022 134 17 funding fund VERB admet-2022 134 18 this this DET admet-2022 134 19 work work NOUN admet-2022 134 20 under under ADP admet-2022 134 21 the the DET admet-2022 134 22 general general ADJ admet-2022 134 23 research research PROPN admet-2022 134 24 funding funding NOUN admet-2022 134 25 program program NOUN admet-2022 134 26 grant grant NOUN admet-2022 134 27 code code PROPN admet-2022 134 28 ( ( PUNCT admet-2022 134 29 nu nu PROPN admet-2022 134 30 / / SYM admet-2022 134 31 drp drp PROPN admet-2022 134 32 / / SYM admet-2022 134 33 mrc/12/40 mrc/12/40 PROPN admet-2022 134 34 ) ) PUNCT admet-2022 134 35 . . PUNCT admet-2022 135 1 conflict conflict NOUN admet-2022 135 2 of of ADP admet-2022 135 3 interest interest NOUN admet-2022 135 4 : : PUNCT admet-2022 135 5 the the DET admet-2022 135 6 authors author NOUN admet-2022 135 7 declare declare VERB admet-2022 135 8 they they PRON admet-2022 135 9 have have VERB admet-2022 135 10 no no DET admet-2022 135 11 conflict conflict NOUN admet-2022 135 12 of of ADP admet-2022 135 13 interest interest NOUN admet-2022 135 14 . . PUNCT admet-2022 136 1 ethics ethic NOUN admet-2022 136 2 approval approval NOUN admet-2022 136 3 and and CCONJ admet-2022 136 4 consent consent NOUN admet-2022 136 5 to to PART admet-2022 136 6 participate participate VERB admet-2022 136 7 : : PUNCT admet-2022 136 8 animal animal NOUN admet-2022 136 9 study study NOUN admet-2022 136 10 was be AUX admet-2022 136 11 approved approve VERB admet-2022 136 12 by by ADP admet-2022 136 13 the the DET admet-2022 136 14 zagazig zagazig PROPN admet-2022 136 15 ethical ethical PROPN admet-2022 136 16 committee committee PROPN admet-2022 136 17 for for ADP admet-2022 136 18 animal animal NOUN admet-2022 136 19 handling handling NOUN admet-2022 136 20 “ " PUNCT admet-2022 136 21 zecah zecah PROPN admet-2022 136 22 ” " PUNCT admet-2022 136 23 guidelines guideline NOUN admet-2022 136 24 ( ( PUNCT admet-2022 136 25 approval approval NOUN admet-2022 136 26 no no INTJ admet-2022 136 27 : : PUNCT admet-2022 136 28 zu zu NOUN admet-2022 136 29 - - PUNCT admet-2022 136 30 iacuc/2 iacuc/2 PRON admet-2022 136 31 / / SYM admet-2022 136 32 f/213/2019 f/213/2019 VERB admet-2022 136 33 ) ) PUNCT admet-2022 136 34 . . PUNCT admet-2022 137 1 references reference NOUN admet-2022 137 2 [ [ X admet-2022 137 3 1 1 X admet-2022 137 4 ] ] PUNCT admet-2022 137 5 s. s. PROPN admet-2022 137 6 kim kim PROPN admet-2022 137 7 , , PUNCT admet-2022 137 8 h. h. PROPN admet-2022 137 9 lee lee PROPN admet-2022 137 10 , , PUNCT admet-2022 137 11 y. y. PROPN admet-2022 137 12 na na PROPN admet-2022 137 13 , , PUNCT admet-2022 137 14 k. k. PROPN admet-2022 137 15 bang bang PROPN admet-2022 137 16 , , PUNCT admet-2022 137 17 h. h. PROPN admet-2022 137 18 lee lee PROPN admet-2022 137 19 , , PUNCT admet-2022 137 20 m. m. PROPN admet-2022 137 21 wang wang PROPN admet-2022 137 22 , , PUNCT admet-2022 137 23 h. h. PROPN admet-2022 137 24 huh huh PROPN admet-2022 137 25 , , PUNCT admet-2022 137 26 c. c. PROPN admet-2022 137 27 cho cho PROPN admet-2022 137 28 . . PUNCT admet-2022 138 1 a a DET admet-2022 138 2 novel novel ADJ admet-2022 138 3 composition composition NOUN admet-2022 138 4 of of ADP admet-2022 138 5 ticagrelor ticagrelor NOUN admet-2022 138 6 by by ADP admet-2022 138 7 solid solid ADJ admet-2022 138 8 dispersion dispersion NOUN admet-2022 138 9 technique technique NOUN admet-2022 138 10 for for ADP admet-2022 138 11 increasing increase VERB admet-2022 138 12 solubility solubility NOUN admet-2022 138 13 and and CCONJ admet-2022 138 14 intestinal intestinal ADJ admet-2022 138 15 permeability permeability NOUN admet-2022 138 16 . . PUNCT admet-2022 139 1 international international ADJ admet-2022 139 2 journal journal PROPN admet-2022 139 3 of of ADP admet-2022 139 4 pharmaceutics pharmaceutic NOUN admet-2022 139 5 555 555 NUM admet-2022 139 6 ( ( PUNCT admet-2022 139 7 2019 2019 NUM admet-2022 139 8 ) ) PUNCT admet-2022 139 9 11 11 NUM admet-2022 139 10 - - SYM admet-2022 139 11 18 18 NUM admet-2022 139 12 . . PUNCT admet-2022 139 13 http://doi.org/10.1016/j.ijpharm.2018.11.038 http://doi.org/10.1016/j.ijpharm.2018.11.038 PROPN admet-2022 139 14 . . PUNCT admet-2022 140 1 [ [ X admet-2022 140 2 2 2 NUM admet-2022 140 3 ] ] X admet-2022 140 4 n. n. NOUN admet-2022 140 5 rasenack rasenack NOUN admet-2022 140 6 , , PUNCT admet-2022 140 7 b. b. PROPN admet-2022 140 8 w. w. PROPN admet-2022 140 9 müller müller PROPN admet-2022 140 10 . . PUNCT admet-2022 141 1 release release NOUN admet-2022 141 2 rate rate NOUN admet-2022 141 3 enhancement enhancement NOUN admet-2022 141 4 by by ADP admet-2022 141 5 in in ADP admet-2022 141 6 situ situ ADJ admet-2022 141 7 micronization micronization NOUN admet-2022 141 8 of of ADP admet-2022 141 9 poorly poorly ADV admet-2022 141 10 watersoluble watersoluble ADJ admet-2022 141 11 drugs drug NOUN admet-2022 141 12 . . PUNCT admet-2022 142 1 pharmaceutical pharmaceutical ADJ admet-2022 142 2 research research NOUN admet-2022 142 3 19 19 NUM admet-2022 142 4 ( ( PUNCT admet-2022 142 5 2002 2002 NUM admet-2022 142 6 ) ) PUNCT admet-2022 142 7 1894 1894 NUM admet-2022 142 8 - - SYM admet-2022 142 9 1900 1900 NUM admet-2022 142 10 . . PUNCT admet-2022 143 1 https://doi.org/10.1023/a:1021410028371 https://doi.org/10.1023/a:1021410028371 PROPN admet-2022 143 2 . . PUNCT admet-2022 144 1 [ [ X admet-2022 144 2 3 3 X admet-2022 144 3 ] ] X admet-2022 144 4 c. c. PROPN admet-2022 144 5 taniguchi taniguchi PROPN admet-2022 144 6 , , PUNCT admet-2022 144 7 y. y. PROPN admet-2022 144 8 kawabata kawabata PROPN admet-2022 144 9 , , PUNCT admet-2022 144 10 k. k. PROPN admet-2022 144 11 wada wada PROPN admet-2022 144 12 , , PUNCT admet-2022 144 13 s. s. PROPN admet-2022 144 14 yamada yamada PROPN admet-2022 144 15 , , PUNCT admet-2022 144 16 s. s. PROPN admet-2022 144 17 onoue onoue PROPN admet-2022 144 18 . . PUNCT admet-2022 145 1 microenvironmental microenvironmental ADJ admet-2022 145 2 ph ph NOUN admet-2022 145 3 - - NOUN admet-2022 145 4 modification modification NOUN admet-2022 145 5 to to PART admet-2022 145 6 improve improve VERB admet-2022 145 7 release release NOUN admet-2022 145 8 behavior behavior NOUN admet-2022 145 9 and and CCONJ admet-2022 145 10 oral oral ADJ admet-2022 145 11 absorption absorption NOUN admet-2022 145 12 for for ADP admet-2022 145 13 drugs drug NOUN admet-2022 145 14 with with ADP admet-2022 145 15 ph ph ADJ admet-2022 145 16 - - ADJ admet-2022 145 17 dependent dependent ADJ admet-2022 145 18 solubility solubility NOUN admet-2022 145 19 . . PUNCT admet-2022 146 1 expert expert ADJ admet-2022 146 2 opinion opinion NOUN admet-2022 146 3 on on ADP admet-2022 146 4 drug drug NOUN admet-2022 146 5 delivery delivery NOUN admet-2022 146 6 11 11 NUM admet-2022 146 7 ( ( PUNCT admet-2022 146 8 2014 2014 NUM admet-2022 146 9 ) ) PUNCT admet-2022 146 10 505 505 NUM admet-2022 146 11 - - SYM admet-2022 146 12 516 516 NUM admet-2022 146 13 . . PUNCT admet-2022 147 1 https://doi.org/10.1517/17425247.2014.881798 https://doi.org/10.1517/17425247.2014.881798 INTJ admet-2022 147 2 . . PUNCT admet-2022 148 1 [ [ X admet-2022 148 2 4 4 X admet-2022 148 3 ] ] PUNCT admet-2022 148 4 m. m. NOUN admet-2022 148 5 ishikawa ishikawa PROPN admet-2022 148 6 , , PUNCT admet-2022 148 7 y. y. PROPN admet-2022 148 8 hashimoto hashimoto NOUN admet-2022 148 9 . . PUNCT admet-2022 149 1 improvement improvement NOUN admet-2022 149 2 in in ADP admet-2022 149 3 aqueous aqueous ADJ admet-2022 149 4 solubility solubility NOUN admet-2022 149 5 in in ADP admet-2022 149 6 small small ADJ admet-2022 149 7 molecule molecule NOUN admet-2022 149 8 drug drug NOUN admet-2022 149 9 discovery discovery NOUN admet-2022 149 10 programs program NOUN admet-2022 149 11 by by ADP admet-2022 149 12 disruption disruption NOUN admet-2022 149 13 of of ADP admet-2022 149 14 molecular molecular ADJ admet-2022 149 15 planarity planarity NOUN admet-2022 149 16 and and CCONJ admet-2022 149 17 symmetry symmetry NOUN admet-2022 149 18 . . PUNCT admet-2022 150 1 journal journal PROPN admet-2022 150 2 of of ADP admet-2022 150 3 medicinal medicinal ADJ admet-2022 150 4 chemistry chemistry NOUN admet-2022 150 5 54 54 NUM admet-2022 150 6 ( ( PUNCT admet-2022 150 7 2011 2011 NUM admet-2022 150 8 ) ) PUNCT admet-2022 150 9 1539 1539 NUM admet-2022 150 10 - - SYM admet-2022 150 11 1554 1554 NUM admet-2022 150 12 . . PUNCT admet-2022 151 1 https://doi.org/10.1021/jm101356p https://doi.org/10.1021/jm101356p NOUN admet-2022 151 2 . . PUNCT admet-2022 152 1 [ [ X admet-2022 152 2 5 5 X admet-2022 152 3 ] ] PUNCT admet-2022 152 4 d. d. PROPN admet-2022 152 5 van van PROPN admet-2022 152 6 staden staden PROPN admet-2022 152 7 , , PUNCT admet-2022 152 8 j. j. PROPN admet-2022 152 9 du du PROPN admet-2022 152 10 plessis plessis PROPN admet-2022 152 11 , , PUNCT admet-2022 152 12 j. j. PROPN admet-2022 152 13 viljoen viljoen PROPN admet-2022 152 14 . . PUNCT admet-2022 153 1 development development NOUN admet-2022 153 2 of of ADP admet-2022 153 3 topical topical ADJ admet-2022 153 4 / / SYM admet-2022 153 5 transdermal transdermal ADJ admet-2022 153 6 self self NOUN admet-2022 153 7 - - PUNCT admet-2022 153 8 emulsifying emulsify VERB admet-2022 153 9 drug drug NOUN admet-2022 153 10 delivery delivery NOUN admet-2022 153 11 systems system NOUN admet-2022 153 12 , , PUNCT admet-2022 153 13 not not PART admet-2022 153 14 as as ADV admet-2022 153 15 simple simple ADJ admet-2022 153 16 as as SCONJ admet-2022 153 17 expected expect VERB admet-2022 153 18 . . PUNCT admet-2022 154 1 scientia scientia PROPN admet-2022 154 2 pharmaceutica pharmaceutica PROPN admet-2022 154 3 88 88 NUM admet-2022 154 4 ( ( PUNCT admet-2022 154 5 2020 2020 NUM admet-2022 154 6 ) ) PUNCT admet-2022 154 7 17 17 NUM admet-2022 154 8 . . PUNCT admet-2022 155 1 https://doi.org/10.3390/scipharm88020017 https://doi.org/10.3390/scipharm88020017 X admet-2022 155 2 . . PUNCT admet-2022 156 1 [ [ X admet-2022 156 2 6 6 NUM admet-2022 156 3 ] ] SYM admet-2022 156 4 a.a a.a PROPN admet-2022 156 5 . . PROPN admet-2022 156 6 date date NOUN admet-2022 156 7 , , PUNCT admet-2022 156 8 n. n. PROPN admet-2022 156 9 desai desai PROPN admet-2022 156 10 , , PUNCT admet-2022 156 11 r. r. PROPN admet-2022 156 12 dixit dixit PROPN admet-2022 156 13 , , PUNCT admet-2022 156 14 m. m. NOUN admet-2022 156 15 nagarsenker nagarsenker PROPN admet-2022 156 16 . . PUNCT admet-2022 157 1 self self NOUN admet-2022 157 2 - - PUNCT admet-2022 157 3 nanoemulsifying nanoemulsifye VERB admet-2022 157 4 drug drug NOUN admet-2022 157 5 delivery delivery NOUN admet-2022 157 6 systems system NOUN admet-2022 157 7 : : PUNCT admet-2022 157 8 formulation formulation NOUN admet-2022 157 9 insights insight NOUN admet-2022 157 10 , , PUNCT admet-2022 157 11 applications application NOUN admet-2022 157 12 and and CCONJ admet-2022 157 13 advances advance NOUN admet-2022 157 14 . . PUNCT admet-2022 158 1 nanomedicine nanomedicine NOUN admet-2022 158 2 5 5 NUM admet-2022 158 3 ( ( PUNCT admet-2022 158 4 2010 2010 NUM admet-2022 158 5 ) ) PUNCT admet-2022 158 6 1595 1595 NUM admet-2022 158 7 - - SYM admet-2022 158 8 1616 1616 NUM admet-2022 158 9 . . PUNCT admet-2022 159 1 https://doi.org/10.2217/nnm.10.126 https://doi.org/10.2217/nnm.10.126 NOUN admet-2022 159 2 . . PUNCT admet-2022 160 1 http://doi.org/10.1016/j.ijpharm.2018.11.038 http://doi.org/10.1016/j.ijpharm.2018.11.038 PROPN admet-2022 160 2 https://doi.org/10.1023/a:1021410028371 https://doi.org/10.1023/a:1021410028371 PROPN admet-2022 160 3 https://doi.org/10.1517/17425247.2014.881798 https://doi.org/10.1517/17425247.2014.881798 PROPN admet-2022 160 4 https://doi.org/10.1021/jm101356p https://doi.org/10.1021/jm101356p X admet-2022 160 5 https://doi.org/10.3390/scipharm88020017 https://doi.org/10.3390/scipharm88020017 X admet-2022 160 6 https://doi.org/10.2217/nnm.10.126 https://doi.org/10.2217/nnm.10.126 PROPN admet-2022 160 7 admet admet PROPN admet-2022 160 8 & & CCONJ admet-2022 160 9 dmpk dmpk PROPN admet-2022 160 10 12(1 12(1 PROPN admet-2022 160 11 ) ) PUNCT admet-2022 160 12 ( ( PUNCT admet-2022 160 13 2024 2024 NUM admet-2022 160 14 ) ) PUNCT admet-2022 160 15 167 167 NUM admet-2022 160 16 - - SYM admet-2022 160 17 176 176 NUM admet-2022 160 18 nanosuspension nanosuspension NOUN admet-2022 160 19 versus versus ADP admet-2022 160 20 self self NOUN admet-2022 160 21 - - PUNCT admet-2022 160 22 nanoemulsifying nanoemulsifye VERB admet-2022 160 23 drug drug NOUN admet-2022 160 24 delivery delivery NOUN admet-2022 160 25 doi doi NOUN admet-2022 160 26 : : PUNCT admet-2022 160 27 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 NOUN admet-2022 160 28 175 175 NUM admet-2022 161 1 [ [ X admet-2022 161 2 7 7 NUM admet-2022 161 3 ] ] X admet-2022 161 4 v.r v.r PROPN admet-2022 161 5 . . PROPN admet-2022 161 6 patel patel PROPN admet-2022 161 7 , , PUNCT admet-2022 161 8 y. y. PROPN admet-2022 161 9 agrawal agrawal PROPN admet-2022 161 10 . . PUNCT admet-2022 162 1 nanosuspension nanosuspension NOUN admet-2022 162 2 : : PUNCT admet-2022 162 3 an an DET admet-2022 162 4 approach approach NOUN admet-2022 162 5 to to PART admet-2022 162 6 enhance enhance VERB admet-2022 162 7 solubility solubility NOUN admet-2022 162 8 of of ADP admet-2022 162 9 drugs drug NOUN admet-2022 162 10 . . PUNCT admet-2022 163 1 journal journal NOUN admet-2022 163 2 of of ADP admet-2022 163 3 advanced advanced ADJ admet-2022 163 4 pharmaceutical pharmaceutical NOUN admet-2022 163 5 technology technology NOUN admet-2022 163 6 & & CCONJ admet-2022 163 7 research research PROPN admet-2022 163 8 2 2 NUM admet-2022 163 9 ( ( PUNCT admet-2022 163 10 2011 2011 NUM admet-2022 163 11 ) ) PUNCT admet-2022 163 12 81 81 NUM admet-2022 163 13 . . PUNCT admet-2022 164 1 https://doi.org/10.4103/2231-4040.82950 https://doi.org/10.4103/2231-4040.82950 PROPN admet-2022 164 2 . . PUNCT admet-2022 165 1 [ [ X admet-2022 165 2 8 8 NUM admet-2022 165 3 ] ] X admet-2022 165 4 v.b v.b PROPN admet-2022 165 5 . . PROPN admet-2022 165 6 patravale patravale PROPN admet-2022 165 7 , , PUNCT admet-2022 165 8 a.a a.a PROPN admet-2022 165 9 . . PROPN admet-2022 165 10 date date PROPN admet-2022 165 11 , , PUNCT admet-2022 165 12 r.m r.m PROPN admet-2022 165 13 . . PROPN admet-2022 165 14 kulkarni kulkarni PROPN admet-2022 165 15 . . PUNCT admet-2022 166 1 nanosuspensions nanosuspension NOUN admet-2022 166 2 : : PUNCT admet-2022 166 3 a a DET admet-2022 166 4 promising promising ADJ admet-2022 166 5 drug drug NOUN admet-2022 166 6 delivery delivery NOUN admet-2022 166 7 systems system NOUN admet-2022 166 8 . . PUNCT admet-2022 167 1 international international ADJ admet-2022 167 2 journal journal PROPN admet-2022 167 3 of of ADP admet-2022 167 4 pharmaceutical pharmaceutical NOUN admet-2022 167 5 sciences science NOUN admet-2022 167 6 and and CCONJ admet-2022 167 7 nanotechnology nanotechnology PROPN admet-2022 167 8 ( ( PUNCT admet-2022 167 9 ijpsn ijpsn PROPN admet-2022 167 10 ) ) PUNCT admet-2022 167 11 2 2 NUM admet-2022 167 12 ( ( PUNCT admet-2022 167 13 2009 2009 NUM admet-2022 167 14 ) ) PUNCT admet-2022 167 15 679 679 NUM admet-2022 167 16 - - SYM admet-2022 167 17 684 684 NUM admet-2022 167 18 . . PUNCT admet-2022 168 1 https://doi.org/10.1211/0022357023691 https://doi.org/10.1211/0022357023691 PROPN admet-2022 168 2 . . PUNCT admet-2022 169 1 [ [ X admet-2022 169 2 9 9 NUM admet-2022 169 3 ] ] PUNCT admet-2022 169 4 r. r. PROPN admet-2022 169 5 yadollahi yadollahi PROPN admet-2022 169 6 , , PUNCT admet-2022 169 7 k. k. PROPN admet-2022 169 8 vasilev vasilev PROPN admet-2022 169 9 , , PUNCT admet-2022 169 10 s. s. PROPN admet-2022 169 11 simovic simovic PROPN admet-2022 169 12 . . PUNCT admet-2022 170 1 nanosuspension nanosuspension NOUN admet-2022 170 2 technologies technology NOUN admet-2022 170 3 for for ADP admet-2022 170 4 delivery delivery NOUN admet-2022 170 5 of of ADP admet-2022 170 6 poorly poorly ADV admet-2022 170 7 soluble soluble ADJ admet-2022 170 8 drugs drug NOUN admet-2022 170 9 . . PUNCT admet-2022 171 1 journal journal NOUN admet-2022 171 2 of of ADP admet-2022 171 3 nanomaterials nanomaterial NOUN admet-2022 171 4 2015 2015 NUM admet-2022 171 5 ( ( PUNCT admet-2022 171 6 2015 2015 NUM admet-2022 171 7 ) ) PUNCT admet-2022 171 8 216375 216375 NUM admet-2022 171 9 . . PUNCT admet-2022 172 1 https://doi.org/10.1155/2015/216375 https://doi.org/10.1155/2015/216375 INTJ admet-2022 172 2 . . PUNCT admet-2022 173 1 [ [ X admet-2022 173 2 10 10 NUM admet-2022 173 3 ] ] X admet-2022 173 4 s. s. PROPN admet-2022 173 5 jacob jacob PROPN admet-2022 173 6 , , PUNCT admet-2022 173 7 a.b a.b PROPN admet-2022 173 8 . . PROPN admet-2022 173 9 nair nair PROPN admet-2022 173 10 , , PUNCT admet-2022 173 11 j. j. PROPN admet-2022 173 12 shah shah PROPN admet-2022 173 13 . . PUNCT admet-2022 174 1 emerging emerge VERB admet-2022 174 2 role role NOUN admet-2022 174 3 of of ADP admet-2022 174 4 nanosuspensions nanosuspension NOUN admet-2022 174 5 in in ADP admet-2022 174 6 drug drug NOUN admet-2022 174 7 delivery delivery NOUN admet-2022 174 8 systems system NOUN admet-2022 174 9 . . PUNCT admet-2022 175 1 biomaterials biomaterial NOUN admet-2022 175 2 research research VERB admet-2022 175 3 24 24 NUM admet-2022 175 4 ( ( PUNCT admet-2022 175 5 2020 2020 NUM admet-2022 175 6 ) ) PUNCT admet-2022 175 7 3 3 NUM admet-2022 175 8 . . PUNCT admet-2022 176 1 https://doi.org/10.1186/s40824-020-0184-8 https://doi.org/10.1186/s40824-020-0184-8 PRON admet-2022 176 2 . . PUNCT admet-2022 177 1 [ [ X admet-2022 177 2 11 11 NUM admet-2022 177 3 ] ] X admet-2022 177 4 m.d m.d PROPN admet-2022 177 5 . . PROPN admet-2022 177 6 prajapat prajapat PROPN admet-2022 177 7 , , PUNCT admet-2022 177 8 n.j n.j PROPN admet-2022 177 9 . . PROPN admet-2022 177 10 patel patel PROPN admet-2022 177 11 , , PUNCT admet-2022 177 12 a. a. NOUN admet-2022 177 13 bariya bariya PROPN admet-2022 177 14 , , PUNCT admet-2022 177 15 s.s s.s PROPN admet-2022 177 16 . . PROPN admet-2022 177 17 patel patel PROPN admet-2022 177 18 , , PUNCT admet-2022 177 19 s.b s.b PROPN admet-2022 177 20 . . PROPN admet-2022 177 21 butani butani PROPN admet-2022 177 22 . . PUNCT admet-2022 178 1 formulation formulation NOUN admet-2022 178 2 and and CCONJ admet-2022 178 3 evaluation evaluation NOUN admet-2022 178 4 of of ADP admet-2022 178 5 selfemulsifying selfemulsifye VERB admet-2022 178 6 drug drug NOUN admet-2022 178 7 delivery delivery NOUN admet-2022 178 8 system system NOUN admet-2022 178 9 for for ADP admet-2022 178 10 nimodipine nimodipine NOUN admet-2022 178 11 , , PUNCT admet-2022 178 12 a a DET admet-2022 178 13 bcs bcs NOUN admet-2022 178 14 class class NOUN admet-2022 178 15 ii ii NOUN admet-2022 178 16 drug drug NOUN admet-2022 178 17 . . PUNCT admet-2022 179 1 journal journal PROPN admet-2022 179 2 of of ADP admet-2022 179 3 drug drug NOUN admet-2022 179 4 delivery delivery NOUN admet-2022 179 5 science science NOUN admet-2022 179 6 and and CCONJ admet-2022 179 7 technology technology NOUN admet-2022 179 8 39 39 NUM admet-2022 179 9 ( ( PUNCT admet-2022 179 10 2017 2017 NUM admet-2022 179 11 ) ) PUNCT admet-2022 179 12 59 59 NUM admet-2022 179 13 - - SYM admet-2022 179 14 68 68 NUM admet-2022 179 15 . . PUNCT admet-2022 179 16 https://doi.org/10.1016/j.jddst.2017.02.002 https://doi.org/10.1016/j.jddst.2017.02.002 X admet-2022 179 17 . . PUNCT admet-2022 180 1 [ [ X admet-2022 180 2 12 12 NUM admet-2022 180 3 ] ] PUNCT admet-2022 180 4 k. k. PROPN admet-2022 180 5 sanka sanka PROPN admet-2022 180 6 , , PUNCT admet-2022 180 7 d. d. PROPN admet-2022 180 8 suda suda PROPN admet-2022 180 9 , , PUNCT admet-2022 180 10 v. v. PROPN admet-2022 180 11 bakshi bakshi PROPN admet-2022 180 12 . . PUNCT admet-2022 181 1 optimization optimization NOUN admet-2022 181 2 of of ADP admet-2022 181 3 solid solid ADJ admet-2022 181 4 - - PUNCT admet-2022 181 5 self self NOUN admet-2022 181 6 nanoemulsifying nanoemulsifye VERB admet-2022 181 7 drug drug NOUN admet-2022 181 8 delivery delivery NOUN admet-2022 181 9 system system NOUN admet-2022 181 10 for for ADP admet-2022 181 11 solubility solubility NOUN admet-2022 181 12 and and CCONJ admet-2022 181 13 release release VERB admet-2022 181 14 profile profile NOUN admet-2022 181 15 of of ADP admet-2022 181 16 clonazepam clonazepam NOUN admet-2022 181 17 using use VERB admet-2022 181 18 simplex simplex NOUN admet-2022 181 19 lattice lattice PROPN admet-2022 181 20 design design NOUN admet-2022 181 21 . . PUNCT admet-2022 182 1 journal journal NOUN admet-2022 182 2 of of ADP admet-2022 182 3 drug drug NOUN admet-2022 182 4 delivery delivery NOUN admet-2022 182 5 science science NOUN admet-2022 182 6 and and CCONJ admet-2022 182 7 technology technology NOUN admet-2022 182 8 33 33 NUM admet-2022 182 9 ( ( PUNCT admet-2022 182 10 2016 2016 NUM admet-2022 182 11 ) ) PUNCT admet-2022 182 12 114 114 NUM admet-2022 182 13 - - SYM admet-2022 182 14 124 124 NUM admet-2022 182 15 . . PUNCT admet-2022 183 1 https://doi.org/10.1016/j.jddst.2016.04.003 https://doi.org/10.1016/j.jddst.2016.04.003 PROPN admet-2022 183 2 . . PUNCT admet-2022 184 1 [ [ X admet-2022 184 2 13 13 NUM admet-2022 184 3 ] ] PUNCT admet-2022 184 4 k. k. PROPN admet-2022 184 5 kohli kohli PROPN admet-2022 184 6 , , PUNCT admet-2022 184 7 s. s. PROPN admet-2022 184 8 chopra chopra PROPN admet-2022 184 9 , , PUNCT admet-2022 184 10 d. d. PROPN admet-2022 184 11 dhar dhar PROPN admet-2022 184 12 , , PUNCT admet-2022 184 13 s. s. PROPN admet-2022 184 14 arora arora PROPN admet-2022 184 15 , , PUNCT admet-2022 184 16 r.k r.k PROPN admet-2022 184 17 . . PROPN admet-2022 184 18 khar khar PROPN admet-2022 184 19 . . PUNCT admet-2022 184 20 self self NOUN admet-2022 184 21 - - PUNCT admet-2022 184 22 emulsifying emulsify VERB admet-2022 184 23 drug drug NOUN admet-2022 184 24 delivery delivery NOUN admet-2022 184 25 systems system NOUN admet-2022 184 26 : : PUNCT admet-2022 184 27 an an DET admet-2022 184 28 approach approach NOUN admet-2022 184 29 to to PART admet-2022 184 30 enhance enhance VERB admet-2022 184 31 oral oral ADJ admet-2022 184 32 bioavailability bioavailability NOUN admet-2022 184 33 . . PUNCT admet-2022 185 1 drug drug NOUN admet-2022 185 2 discovery discovery PROPN admet-2022 185 3 today today NOUN admet-2022 185 4 15 15 NUM admet-2022 185 5 ( ( PUNCT admet-2022 185 6 2010 2010 NUM admet-2022 185 7 ) ) PUNCT admet-2022 185 8 958 958 NUM admet-2022 185 9 - - SYM admet-2022 185 10 965 965 NUM admet-2022 185 11 . . PUNCT admet-2022 186 1 https://doi.org/10.1016/j.drudis.2010.08.007 https://doi.org/10.1016/j.drudis.2010.08.007 NOUN admet-2022 186 2 . . PUNCT admet-2022 187 1 [ [ X admet-2022 187 2 14 14 NUM admet-2022 187 3 ] ] PUNCT admet-2022 187 4 m. m. NOUN admet-2022 187 5 shafique shafique NOUN admet-2022 187 6 , , PUNCT admet-2022 187 7 m.a m.a PROPN admet-2022 187 8 . . PROPN admet-2022 187 9 khan khan PROPN admet-2022 187 10 , , PUNCT admet-2022 187 11 w.s w.s PROPN admet-2022 187 12 . . PROPN admet-2022 187 13 khan khan PROPN admet-2022 187 14 , , PUNCT admet-2022 187 15 w. w. PROPN admet-2022 187 16 ahmad ahmad PROPN admet-2022 187 17 , , PUNCT admet-2022 187 18 s. s. PROPN admet-2022 187 19 khan khan PROPN admet-2022 187 20 . . PUNCT admet-2022 188 1 fabrication fabrication NOUN admet-2022 188 2 , , PUNCT admet-2022 188 3 characterization characterization NOUN admet-2022 188 4 , , PUNCT admet-2022 188 5 and and CCONJ admet-2022 188 6 in in ADP admet-2022 188 7 vivo vivo ADJ admet-2022 188 8 evaluation evaluation NOUN admet-2022 188 9 of of ADP admet-2022 188 10 famotidine famotidine NOUN admet-2022 188 11 loaded load VERB admet-2022 188 12 solid solid ADJ admet-2022 188 13 lipid lipid NOUN admet-2022 188 14 nanoparticles nanoparticle NOUN admet-2022 188 15 for for ADP admet-2022 188 16 boosting boost VERB admet-2022 188 17 oral oral ADJ admet-2022 188 18 bioavailability bioavailability NOUN admet-2022 188 19 . . PUNCT admet-2022 189 1 journal journal PROPN admet-2022 189 2 of of ADP admet-2022 189 3 nanomaterials nanomaterial NOUN admet-2022 189 4 2017 2017 NUM admet-2022 189 5 ( ( PUNCT admet-2022 189 6 2017 2017 NUM admet-2022 189 7 ) ) PUNCT admet-2022 189 8 7357150 7357150 NUM admet-2022 189 9 . . PUNCT admet-2022 190 1 https://doi.org/10.1155/2017/7357150 https://doi.org/10.1155/2017/7357150 NOUN admet-2022 190 2 . . PUNCT admet-2022 191 1 [ [ X admet-2022 191 2 15 15 NUM admet-2022 191 3 ] ] X admet-2022 191 4 a. a. NOUN admet-2022 191 5 nasr nasr PROPN admet-2022 191 6 , , PUNCT admet-2022 191 7 a. a. NOUN admet-2022 191 8 gardouh gardouh PROPN admet-2022 191 9 , , PUNCT admet-2022 191 10 m. m. NOUN admet-2022 191 11 ghorab ghorab NOUN admet-2022 191 12 . . PUNCT admet-2022 192 1 novel novel PROPN admet-2022 192 2 solid solid ADJ admet-2022 192 3 self self NOUN admet-2022 192 4 - - PUNCT admet-2022 192 5 nanoemulsifying nanoemulsifye VERB admet-2022 192 6 drug drug NOUN admet-2022 192 7 delivery delivery NOUN admet-2022 192 8 system system NOUN admet-2022 192 9 ( ( PUNCT admet-2022 192 10 ssnedds ssnedds PROPN admet-2022 192 11 ) ) PUNCT admet-2022 192 12 for for ADP admet-2022 192 13 oral oral ADJ admet-2022 192 14 delivery delivery NOUN admet-2022 192 15 of of ADP admet-2022 192 16 olmesartan olmesartan PROPN admet-2022 192 17 medoxomil medoxomil PROPN admet-2022 192 18 : : PUNCT admet-2022 192 19 design design NOUN admet-2022 192 20 , , PUNCT admet-2022 192 21 formulation formulation NOUN admet-2022 192 22 , , PUNCT admet-2022 192 23 pharmacokinetic pharmacokinetic ADJ admet-2022 192 24 and and CCONJ admet-2022 192 25 bioavailability bioavailability NOUN admet-2022 192 26 evaluation evaluation NOUN admet-2022 192 27 . . PUNCT admet-2022 193 1 pharmaceutics pharmaceutic NOUN admet-2022 193 2 8 8 NUM admet-2022 193 3 ( ( PUNCT admet-2022 193 4 2016 2016 NUM admet-2022 193 5 ) ) PUNCT admet-2022 193 6 20 20 NUM admet-2022 193 7 . . PUNCT admet-2022 193 8 https://doi.org/10.3390/pharmaceutics8030020 https://doi.org/10.3390/pharmaceutics8030020 NOUN admet-2022 193 9 . . PUNCT admet-2022 194 1 [ [ X admet-2022 194 2 16 16 NUM admet-2022 194 3 ] ] X admet-2022 194 4 p.k p.k PROPN admet-2022 194 5 . . PROPN admet-2022 194 6 whelton whelton PROPN admet-2022 194 7 , , PUNCT admet-2022 194 8 r.m r.m PROPN admet-2022 194 9 . . PROPN admet-2022 194 10 carey carey PROPN admet-2022 194 11 , , PUNCT admet-2022 194 12 w.s w.s PROPN admet-2022 194 13 . . PROPN admet-2022 194 14 aronow aronow PROPN admet-2022 194 15 , , PUNCT admet-2022 194 16 d.e d.e PROPN admet-2022 194 17 . . PROPN admet-2022 194 18 casey casey PROPN admet-2022 194 19 , , PUNCT admet-2022 194 20 k.j k.j PROPN admet-2022 194 21 . . PROPN admet-2022 194 22 collins collins PROPN admet-2022 194 23 , , PUNCT admet-2022 194 24 c. c. PROPN admet-2022 194 25 dennison dennison PROPN admet-2022 194 26 himmelfarb himmelfarb PROPN admet-2022 194 27 , , PUNCT admet-2022 194 28 s.m s.m PROPN admet-2022 194 29 . . PROPN admet-2022 194 30 depalma depalma PROPN admet-2022 194 31 , , PUNCT admet-2022 194 32 s. s. PROPN admet-2022 194 33 gidding gidding PROPN admet-2022 194 34 , , PUNCT admet-2022 194 35 k.a k.a PROPN admet-2022 194 36 . . PROPN admet-2022 194 37 jamerson jamerson PROPN admet-2022 194 38 , , PUNCT admet-2022 194 39 d.w d.w PROPN admet-2022 194 40 . . PROPN admet-2022 194 41 jones jones PROPN admet-2022 194 42 . . PROPN admet-2022 194 43 2017 2017 NUM admet-2022 194 44 acc acc PROPN admet-2022 194 45 / / SYM admet-2022 194 46 aha aha INTJ admet-2022 194 47 / / SYM admet-2022 194 48 aapa aapa VERB admet-2022 194 49 / / SYM admet-2022 194 50 abc abc PROPN admet-2022 194 51 / / SYM admet-2022 194 52 acpm acpm NOUN admet-2022 194 53 / / SYM admet-2022 194 54 ags ag NOUN admet-2022 194 55 / / SYM admet-2022 194 56 apha/ apha/ NUM admet-2022 194 57 /ash /ash ADJ admet-2022 194 58 / / SYM admet-2022 194 59 aspc aspc NOUN admet-2022 194 60 / / SYM admet-2022 194 61 nma nma PROPN admet-2022 194 62 / / SYM admet-2022 194 63 pcna pcna PROPN admet-2022 194 64 guideline guideline NOUN admet-2022 194 65 for for ADP admet-2022 194 66 the the DET admet-2022 194 67 prevention prevention NOUN admet-2022 194 68 , , PUNCT admet-2022 194 69 detection detection NOUN admet-2022 194 70 , , PUNCT admet-2022 194 71 evaluation evaluation NOUN admet-2022 194 72 , , PUNCT admet-2022 194 73 and and CCONJ admet-2022 194 74 management management NOUN admet-2022 194 75 of of ADP admet-2022 194 76 high high ADJ admet-2022 194 77 blood blood NOUN admet-2022 194 78 pressure pressure NOUN admet-2022 194 79 in in ADP admet-2022 194 80 adults adult NOUN admet-2022 194 81 : : PUNCT admet-2022 194 82 a a DET admet-2022 194 83 report report NOUN admet-2022 194 84 of of ADP admet-2022 194 85 the the DET admet-2022 194 86 american american PROPN admet-2022 194 87 college college PROPN admet-2022 194 88 of of ADP admet-2022 194 89 cardiology cardiology NOUN admet-2022 194 90 / / SYM admet-2022 194 91 american american PROPN admet-2022 194 92 heart heart PROPN admet-2022 194 93 association association PROPN admet-2022 194 94 task task NOUN admet-2022 194 95 force force NOUN admet-2022 194 96 on on ADP admet-2022 194 97 clinical clinical ADJ admet-2022 194 98 practice practice NOUN admet-2022 194 99 guidelines guideline NOUN admet-2022 194 100 . . PUNCT admet-2022 195 1 journal journal NOUN admet-2022 195 2 of of ADP admet-2022 195 3 the the DET admet-2022 195 4 american american PROPN admet-2022 195 5 college college PROPN admet-2022 195 6 of of ADP admet-2022 195 7 cardiology cardiology NOUN admet-2022 195 8 71 71 NUM admet-2022 195 9 ( ( PUNCT admet-2022 195 10 2018 2018 NUM admet-2022 195 11 ) ) PUNCT admet-2022 195 12 e127 e127 PROPN admet-2022 195 13 - - PUNCT admet-2022 195 14 e248 e248 PROPN admet-2022 195 15 . . PUNCT admet-2022 196 1 https://doi.org/10.1001/jama.2017.18209 https://doi.org/10.1001/jama.2017.18209 NOUN admet-2022 196 2 . . PUNCT admet-2022 197 1 [ [ X admet-2022 197 2 17 17 NUM admet-2022 197 3 ] ] X admet-2022 197 4 h.h h.h PROPN admet-2022 197 5 . . PROPN admet-2022 197 6 ali ali PROPN admet-2022 197 7 , , PUNCT admet-2022 197 8 a.a a.a PROPN admet-2022 197 9 . . PROPN admet-2022 197 10 hussein hussein PROPN admet-2022 197 11 . . PUNCT admet-2022 198 1 oral oral ADJ admet-2022 198 2 solid solid ADJ admet-2022 198 3 self self NOUN admet-2022 198 4 - - PUNCT admet-2022 198 5 nanoemulsifying nanoemulsifye VERB admet-2022 198 6 drug drug NOUN admet-2022 198 7 delivery delivery NOUN admet-2022 198 8 systems system NOUN admet-2022 198 9 of of ADP admet-2022 198 10 candesartan candesartan PROPN admet-2022 198 11 citexetil citexetil PROPN admet-2022 198 12 : : PUNCT admet-2022 198 13 formulation formulation NOUN admet-2022 198 14 , , PUNCT admet-2022 198 15 characterization characterization NOUN admet-2022 198 16 and and CCONJ admet-2022 198 17 in in ADP admet-2022 198 18 vitro vitro X admet-2022 198 19 drug drug NOUN admet-2022 198 20 release release NOUN admet-2022 198 21 studies study NOUN admet-2022 198 22 . . PUNCT admet-2022 199 1 aaps aap NOUN admet-2022 199 2 open open VERB admet-2022 199 3 3 3 NUM admet-2022 199 4 ( ( PUNCT admet-2022 199 5 2017 2017 NUM admet-2022 199 6 ) ) PUNCT admet-2022 199 7 6 6 NUM admet-2022 199 8 . . PUNCT admet-2022 200 1 https://doi.org/10.1186/s41120-017-0015-8 https://doi.org/10.1186/s41120-017-0015-8 NUM admet-2022 200 2 . . PUNCT admet-2022 201 1 [ [ X admet-2022 201 2 18 18 NUM admet-2022 201 3 ] ] X admet-2022 201 4 g. g. PROPN admet-2022 201 5 preethi preethi PROPN admet-2022 201 6 , , PUNCT admet-2022 201 7 s. s. PROPN admet-2022 201 8 banerjee banerjee PROPN admet-2022 201 9 , , PUNCT admet-2022 201 10 h. h. PROPN admet-2022 201 11 shivakumar shivakumar PROPN admet-2022 201 12 , , PUNCT admet-2022 201 13 m. m. PROPN admet-2022 201 14 ravi ravi PROPN admet-2022 201 15 kumar kumar PROPN admet-2022 201 16 . . PUNCT admet-2022 202 1 formulation formulation NOUN admet-2022 202 2 of of ADP admet-2022 202 3 fast fast ADV admet-2022 202 4 - - PUNCT admet-2022 202 5 dissolving dissolve VERB admet-2022 202 6 tablets tablet NOUN admet-2022 202 7 of of ADP admet-2022 202 8 doxazosin doxazosin NOUN admet-2022 202 9 mesylate mesylate NOUN admet-2022 202 10 drug drug NOUN admet-2022 202 11 by by ADP admet-2022 202 12 direct direct ADJ admet-2022 202 13 compression compression NOUN admet-2022 202 14 method method NOUN admet-2022 202 15 . . PUNCT admet-2022 203 1 international international ADJ admet-2022 203 2 journal journal NOUN admet-2022 203 3 of of ADP admet-2022 203 4 applied apply VERB admet-2022 203 5 pharmaceutics pharmaceutic NOUN admet-2022 203 6 9 9 NUM admet-2022 203 7 ( ( PUNCT admet-2022 203 8 2017 2017 NUM admet-2022 203 9 ) ) PUNCT admet-2022 203 10 22 22 NUM admet-2022 203 11 - - SYM admet-2022 203 12 28 28 NUM admet-2022 203 13 . . PUNCT admet-2022 204 1 https://doi.org/10.22159/ijap.2017v9i5.18168 https://doi.org/10.22159/ijap.2017v9i5.18168 NOUN admet-2022 204 2 . . PUNCT admet-2022 205 1 [ [ X admet-2022 205 2 19 19 NUM admet-2022 205 3 ] ] X admet-2022 205 4 a.g a.g PROPN admet-2022 205 5 . . PROPN admet-2022 205 6 al al PROPN admet-2022 205 7 ashmawy ashmawy PROPN admet-2022 205 8 , , PUNCT admet-2022 205 9 n.g n.g PROPN admet-2022 205 10 . . PROPN admet-2022 205 11 eissa eissa PROPN admet-2022 205 12 , , PUNCT admet-2022 205 13 h.m h.m PROPN admet-2022 205 14 . . PROPN admet-2022 205 15 el el PROPN admet-2022 205 16 nahas nahas PROPN admet-2022 205 17 , , PUNCT admet-2022 205 18 g.f g.f PROPN admet-2022 205 19 . . PROPN admet-2022 205 20 balata balata PROPN admet-2022 205 21 . . PUNCT admet-2022 206 1 fast fast ADJ admet-2022 206 2 disintegrating disintegrate VERB admet-2022 206 3 tablet tablet NOUN admet-2022 206 4 of of ADP admet-2022 206 5 doxazosin doxazosin PROPN admet-2022 206 6 mesylate mesylate NOUN admet-2022 206 7 nanosuspension nanosuspension NOUN admet-2022 206 8 : : PUNCT admet-2022 206 9 preparation preparation NOUN admet-2022 206 10 and and CCONJ admet-2022 206 11 characterization characterization NOUN admet-2022 206 12 . . PUNCT admet-2022 207 1 journal journal NOUN admet-2022 207 2 of of ADP admet-2022 207 3 drug drug NOUN admet-2022 207 4 delivery delivery NOUN admet-2022 207 5 science science NOUN admet-2022 207 6 and and CCONJ admet-2022 207 7 technology technology NOUN admet-2022 207 8 61 61 NUM admet-2022 207 9 ( ( PUNCT admet-2022 207 10 2021 2021 NUM admet-2022 207 11 ) ) PUNCT admet-2022 207 12 102210 102210 NUM admet-2022 207 13 . . PUNCT admet-2022 208 1 https://doi.org/10.1016/j.jddst.2020.102210 https://doi.org/10.1016/j.jddst.2020.102210 NOUN admet-2022 208 2 . . PUNCT admet-2022 209 1 [ [ X admet-2022 209 2 20 20 NUM admet-2022 209 3 ] ] X admet-2022 209 4 a.g a.g PROPN admet-2022 209 5 . . PROPN admet-2022 209 6 al al PROPN admet-2022 209 7 ashmawy ashmawy PROPN admet-2022 209 8 , , PUNCT admet-2022 209 9 n.g n.g PROPN admet-2022 209 10 . . PROPN admet-2022 209 11 eissa eissa PROPN admet-2022 209 12 , , PUNCT admet-2022 209 13 g.f g.f PROPN admet-2022 209 14 . . PROPN admet-2022 209 15 balata balata PROPN admet-2022 209 16 , , PUNCT admet-2022 209 17 h.m h.m PROPN admet-2022 209 18 . . PROPN admet-2022 209 19 el el PROPN admet-2022 209 20 nahas nahas PROPN admet-2022 209 21 . . PUNCT admet-2022 209 22 new new ADJ admet-2022 209 23 approach approach NOUN admet-2022 209 24 for for ADP admet-2022 209 25 administration administration NOUN admet-2022 209 26 of of ADP admet-2022 209 27 doxazosin doxazosin PROPN admet-2022 209 28 mesylate mesylate NOUN admet-2022 209 29 : : PUNCT admet-2022 209 30 comparative comparative ADJ admet-2022 209 31 study study NOUN admet-2022 209 32 between between ADP admet-2022 209 33 liquid liquid NOUN admet-2022 209 34 and and CCONJ admet-2022 209 35 solid solid ADJ admet-2022 209 36 self self NOUN admet-2022 209 37 - - PUNCT admet-2022 209 38 nanoemulsifying nanoemulsifye VERB admet-2022 209 39 drug drug NOUN admet-2022 209 40 delivery delivery NOUN admet-2022 209 41 systems system NOUN admet-2022 209 42 . . PUNCT admet-2022 210 1 international international ADJ admet-2022 210 2 journal journal PROPN admet-2022 210 3 of of ADP admet-2022 210 4 research research NOUN admet-2022 210 5 in in ADP admet-2022 210 6 pharmaceutical pharmaceutical ADJ admet-2022 210 7 sciences science NOUN admet-2022 210 8 12(2 12(2 NUM admet-2022 210 9 ) ) PUNCT admet-2022 210 10 ( ( PUNCT admet-2022 210 11 2021 2021 NUM admet-2022 210 12 ) ) PUNCT admet-2022 210 13 10951101 10951101 NUM admet-2022 210 14 . . PUNCT admet-2022 211 1 https://ijrps.com/home/article/view/93 https://ijrps.com/home/article/view/93 PROPN admet-2022 211 2 . . PUNCT admet-2022 212 1 [ [ X admet-2022 212 2 21 21 NUM admet-2022 212 3 ] ] X admet-2022 212 4 m.a m.a PROPN admet-2022 212 5 . . PROPN admet-2022 212 6 hadi hadi PROPN admet-2022 212 7 , , PUNCT admet-2022 212 8 n.r n.r PROPN admet-2022 212 9 . . PROPN admet-2022 212 10 rao rao PROPN admet-2022 212 11 , , PUNCT admet-2022 212 12 a.s a.s PROPN admet-2022 212 13 . . PROPN admet-2022 212 14 rao rao PROPN admet-2022 212 15 . . PUNCT admet-2022 213 1 formulation formulation NOUN admet-2022 213 2 and and CCONJ admet-2022 213 3 evaluation evaluation NOUN admet-2022 213 4 of of ADP admet-2022 213 5 ph ph ADJ admet-2022 213 6 - - PUNCT admet-2022 213 7 responsive responsive ADJ admet-2022 213 8 mini mini NOUN admet-2022 213 9 - - NOUN admet-2022 213 10 tablets tablet NOUN admet-2022 213 11 for for ADP admet-2022 213 12 ileocolonic ileocolonic ADJ admet-2022 213 13 targeted target VERB admet-2022 213 14 drug drug NOUN admet-2022 213 15 delivery delivery NOUN admet-2022 213 16 . . PUNCT admet-2022 214 1 tropical tropical ADJ admet-2022 214 2 journal journal PROPN admet-2022 214 3 of of ADP admet-2022 214 4 pharmaceutical pharmaceutical ADJ admet-2022 214 5 research research NOUN admet-2022 214 6 13 13 NUM admet-2022 214 7 ( ( PUNCT admet-2022 214 8 2014 2014 NUM admet-2022 214 9 ) ) PUNCT admet-2022 214 10 1021 1021 NUM admet-2022 214 11 - - SYM admet-2022 214 12 1029 1029 NUM admet-2022 214 13 . . PUNCT admet-2022 215 1 https://doi.org/10.4314/tjpr.v13i7.3 https://doi.org/10.4314/tjpr.v13i7.3 PROPN admet-2022 215 2 . . PUNCT admet-2022 216 1 [ [ X admet-2022 216 2 22 22 NUM admet-2022 216 3 ] ] PUNCT admet-2022 216 4 b. b. PROPN admet-2022 216 5 pe pe PROPN admet-2022 216 6 . . PUNCT admet-2022 217 1 percutaneous percutaneous ADJ admet-2022 217 2 treatment treatment NOUN admet-2022 217 3 of of ADP admet-2022 217 4 low low ADJ admet-2022 217 5 flow flow NOUN admet-2022 217 6 vascular vascular ADJ admet-2022 217 7 malformations malformation NOUN admet-2022 217 8 . . PUNCT admet-2022 218 1 journal journal NOUN admet-2022 218 2 of of ADP admet-2022 218 3 vascular vascular ADJ admet-2022 218 4 and and CCONJ admet-2022 218 5 interventional interventional ADJ admet-2022 218 6 radiology radiology NOUN admet-2022 218 7 15 15 NUM admet-2022 218 8 ( ( PUNCT admet-2022 218 9 2004 2004 NUM admet-2022 218 10 ) ) PUNCT admet-2022 218 11 431 431 NUM admet-2022 218 12 - - SYM admet-2022 218 13 445 445 NUM admet-2022 218 14 . . PUNCT admet-2022 219 1 https://doi.org/10.1097/01.rvi.0000124949.24134.cf https://doi.org/10.1097/01.rvi.0000124949.24134.cf AUX admet-2022 219 2 . . PUNCT admet-2022 219 3 https://doi.org/10.5599/admet.2022 https://doi.org/10.5599/admet.2022 PROPN admet-2022 219 4 https://doi.org/10.4103/2231-4040.82950 https://doi.org/10.4103/2231-4040.82950 PROPN admet-2022 219 5 https://doi.org/10.1211/0022357023691 https://doi.org/10.1211/0022357023691 X admet-2022 220 1 https://doi.org/10.1155/2015/216375 https://doi.org/10.1155/2015/216375 PROPN admet-2022 220 2 https://doi.org/10.1186/s40824-020-0184-8 https://doi.org/10.1186/s40824-020-0184-8 NUM admet-2022 221 1 https://doi.org/10.1016/j.jddst.2017.02.002 https://doi.org/10.1016/j.jddst.2017.02.002 NUM admet-2022 221 2 https://doi.org/10.1016/j.jddst.2016.04.003 https://doi.org/10.1016/j.jddst.2016.04.003 PROPN admet-2022 221 3 https://doi.org/10.1016/j.drudis.2010.08.007 https://doi.org/10.1016/j.drudis.2010.08.007 PROPN admet-2022 221 4 https://doi.org/10.1155/2017/7357150 https://doi.org/10.1155/2017/7357150 PROPN admet-2022 221 5 https://doi.org/10.3390/pharmaceutics8030020 https://doi.org/10.3390/pharmaceutics8030020 NOUN admet-2022 221 6 https://doi.org/10.1001/jama.2017.18209 https://doi.org/10.1001/jama.2017.18209 PROPN admet-2022 221 7 https://doi.org/10.1186/s41120-017-0015-8 https://doi.org/10.1186/s41120-017-0015-8 NUM admet-2022 221 8 https://doi.org/10.22159/ijap.2017v9i5.18168 https://doi.org/10.22159/ijap.2017v9i5.18168 NUM admet-2022 221 9 https://doi.org/10.1016/j.jddst.2020.102210 https://doi.org/10.1016/j.jddst.2020.102210 PROPN admet-2022 221 10 https://ijrps.com/home/article/view/93 https://ijrps.com/home/article/view/93 PROPN admet-2022 221 11 https://doi.org/10.4314/tjpr.v13i7.3 https://doi.org/10.4314/tjpr.v13i7.3 PROPN admet-2022 221 12 https://doi.org/10.1097/01.rvi.0000124949.24134.cf https://doi.org/10.1097/01.rvi.0000124949.24134.cf PROPN admet-2022 221 13 a. a. NOUN admet-2022 221 14 z. z. PROPN admet-2022 221 15 g. g. PROPN admet-2022 221 16 al al PROPN admet-2022 221 17 ashmawy ashmawy PROPN admet-2022 221 18 et et PROPN admet-2022 221 19 al al PROPN admet-2022 221 20 . . PROPN admet-2022 221 21 admet admet PROPN admet-2022 221 22 & & CCONJ admet-2022 221 23 dmpk dmpk PROPN admet-2022 221 24 12(1 12(1 PROPN admet-2022 221 25 ) ) PUNCT admet-2022 221 26 ( ( PUNCT admet-2022 221 27 2024 2024 NUM admet-2022 221 28 ) ) PUNCT admet-2022 221 29 167 167 NUM admet-2022 221 30 - - SYM admet-2022 221 31 176 176 NUM admet-2022 221 32 176 176 NUM admet-2022 221 33 [ [ X admet-2022 221 34 23 23 NUM admet-2022 221 35 ] ] X admet-2022 221 36 s. s. PROPN admet-2022 221 37 parasuraman parasuraman PROPN admet-2022 221 38 , , PUNCT admet-2022 221 39 r. r. PROPN admet-2022 221 40 raveendran raveendran PROPN admet-2022 221 41 . . PUNCT admet-2022 222 1 measurement measurement NOUN admet-2022 222 2 of of ADP admet-2022 222 3 invasive invasive ADJ admet-2022 222 4 blood blood NOUN admet-2022 222 5 pressure pressure NOUN admet-2022 222 6 in in ADP admet-2022 222 7 rats rat NOUN admet-2022 222 8 . . PUNCT admet-2022 223 1 journal journal NOUN admet-2022 223 2 of of ADP admet-2022 223 3 pharmacology pharmacology NOUN admet-2022 223 4 and and CCONJ admet-2022 223 5 pharmacotherapeutics pharmacotherapeutic NOUN admet-2022 223 6 3 3 NUM admet-2022 223 7 ( ( PUNCT admet-2022 223 8 2012 2012 NUM admet-2022 223 9 ) ) PUNCT admet-2022 223 10 172 172 NUM admet-2022 223 11 - - SYM admet-2022 223 12 177 177 NUM admet-2022 223 13 . . PUNCT admet-2022 224 1 https://pubmed.ncbi.nlm.nih.gov/22629093/. https://pubmed.ncbi.nlm.nih.gov/22629093/. PROPN admet-2022 224 2 [ [ X admet-2022 224 3 24 24 NUM admet-2022 224 4 ] ] X admet-2022 224 5 h. h. PROPN admet-2022 224 6 kiers kiers PROPN admet-2022 224 7 , , PUNCT admet-2022 224 8 j. j. PROPN admet-2022 224 9 hofstra hofstra PROPN admet-2022 224 10 , , PUNCT admet-2022 224 11 j. j. PROPN admet-2022 224 12 wetzels wetzels PROPN admet-2022 224 13 . . PUNCT admet-2022 225 1 oscillometric oscillometric ADJ admet-2022 225 2 blood blood NOUN admet-2022 225 3 pressure pressure NOUN admet-2022 225 4 measurements measurement NOUN admet-2022 225 5 : : PUNCT admet-2022 225 6 differences difference NOUN admet-2022 225 7 between between ADP admet-2022 225 8 measured measured ADJ admet-2022 225 9 and and CCONJ admet-2022 225 10 calculated calculate VERB admet-2022 225 11 mean mean NOUN admet-2022 225 12 arterial arterial ADJ admet-2022 225 13 pressure pressure NOUN admet-2022 225 14 . . PUNCT admet-2022 226 1 the the DET admet-2022 226 2 netherlands netherlands PROPN admet-2022 226 3 journal journal PROPN admet-2022 226 4 of of ADP admet-2022 226 5 medicine medicine NOUN admet-2022 226 6 66 66 NUM admet-2022 226 7 ( ( PUNCT admet-2022 226 8 2008 2008 NUM admet-2022 226 9 ) ) PUNCT admet-2022 226 10 474 474 NUM admet-2022 226 11 - - SYM admet-2022 226 12 479 479 NUM admet-2022 226 13 . . PUNCT admet-2022 227 1 https://europepmc.org/article/med/19075313 https://europepmc.org/article/med/19075313 PROPN admet-2022 227 2 . . PUNCT admet-2022 228 1 [ [ X admet-2022 228 2 25 25 NUM admet-2022 228 3 ] ] PUNCT admet-2022 228 4 s.g.m s.g.m PROPN admet-2022 228 5 . . PROPN admet-2022 228 6 ong ong PROPN admet-2022 228 7 , , PUNCT admet-2022 228 8 l.c l.c PROPN admet-2022 228 9 . . PROPN admet-2022 228 10 ming ming PROPN admet-2022 228 11 , , PUNCT admet-2022 228 12 k.s k.s PROPN admet-2022 228 13 . . PROPN admet-2022 228 14 lee lee PROPN admet-2022 228 15 , , PUNCT admet-2022 228 16 k.h k.h PROPN admet-2022 228 17 . . PROPN admet-2022 228 18 yuen yuen PROPN admet-2022 228 19 . . PUNCT admet-2022 229 1 influence influence NOUN admet-2022 229 2 of of ADP admet-2022 229 3 the the DET admet-2022 229 4 encapsulation encapsulation NOUN admet-2022 229 5 efficiency efficiency NOUN admet-2022 229 6 and and CCONJ admet-2022 229 7 size size NOUN admet-2022 229 8 of of ADP admet-2022 229 9 liposome liposome NOUN admet-2022 229 10 on on ADP admet-2022 229 11 the the DET admet-2022 229 12 oral oral ADJ admet-2022 229 13 bioavailability bioavailability NOUN admet-2022 229 14 of of ADP admet-2022 229 15 griseofulvin griseofulvin NOUN admet-2022 229 16 - - PUNCT admet-2022 229 17 loaded load VERB admet-2022 229 18 liposomes liposome NOUN admet-2022 229 19 . . PUNCT admet-2022 230 1 pharmaceutics pharmaceutic NOUN admet-2022 230 2 8 8 NUM admet-2022 230 3 ( ( PUNCT admet-2022 230 4 2016 2016 NUM admet-2022 230 5 ) ) PUNCT admet-2022 230 6 25 25 NUM admet-2022 230 7 . . PUNCT admet-2022 230 8 https://doi.org/10.3390/pharmaceutics8030025 https://doi.org/10.3390/pharmaceutics8030025 NOUN admet-2022 230 9 . . PUNCT admet-2022 231 1 [ [ X admet-2022 231 2 26 26 NUM admet-2022 231 3 ] ] SYM admet-2022 231 4 p.m. p.m. NOUN admet-2022 232 1 chaudhari chaudhari PROPN admet-2022 232 2 , , PUNCT admet-2022 232 3 m.a m.a PROPN admet-2022 232 4 . . PROPN admet-2022 232 5 kuchekar kuchekar PROPN admet-2022 232 6 . . PUNCT admet-2022 233 1 development development NOUN admet-2022 233 2 and and CCONJ admet-2022 233 3 evaluation evaluation NOUN admet-2022 233 4 of of ADP admet-2022 233 5 nanoemulsion nanoemulsion NOUN admet-2022 233 6 as as ADP admet-2022 233 7 a a DET admet-2022 233 8 carrier carrier NOUN admet-2022 233 9 for for ADP admet-2022 233 10 topical topical ADJ admet-2022 233 11 delivery delivery NOUN admet-2022 233 12 system system NOUN admet-2022 233 13 by by ADP admet-2022 233 14 box box NOUN admet-2022 233 15 - - PUNCT admet-2022 233 16 behnken behnken VERB admet-2022 233 17 design design NOUN admet-2022 233 18 . . PUNCT admet-2022 234 1 development development NOUN admet-2022 234 2 11 11 NUM admet-2022 234 3 ( ( PUNCT admet-2022 234 4 2018 2018 NUM admet-2022 234 5 ) ) PUNCT admet-2022 234 6 286 286 NUM admet-2022 234 7 - - SYM admet-2022 234 8 293 293 NUM admet-2022 234 9 . . PUNCT admet-2022 235 1 https://doi.org/10.22159/ajpcr.2018.v11i8.26359 https://doi.org/10.22159/ajpcr.2018.v11i8.26359 X admet-2022 235 2 . . PUNCT admet-2022 236 1 [ [ X admet-2022 236 2 27 27 NUM admet-2022 236 3 ] ] PUNCT admet-2022 236 4 m. m. NOUN admet-2022 236 5 kazi kazi PROPN admet-2022 236 6 , , PUNCT admet-2022 236 7 m. m. PROPN admet-2022 236 8 al al PROPN admet-2022 236 9 - - PUNCT admet-2022 236 10 swairi swairi PROPN admet-2022 236 11 , , PUNCT admet-2022 236 12 a. a. PROPN admet-2022 236 13 ahmad ahmad PROPN admet-2022 236 14 , , PUNCT admet-2022 236 15 m. m. NOUN admet-2022 236 16 raish raish NOUN admet-2022 236 17 , , PUNCT admet-2022 236 18 f.k f.k PROPN admet-2022 236 19 . . PROPN admet-2022 236 20 alanazi alanazi PROPN admet-2022 236 21 , , PUNCT admet-2022 236 22 m.m m.m PROPN admet-2022 236 23 . . PROPN admet-2022 236 24 badran badran PROPN admet-2022 236 25 , , PUNCT admet-2022 236 26 a.a a.a PROPN admet-2022 236 27 . . PROPN admet-2022 236 28 khan khan PROPN admet-2022 236 29 , , PUNCT admet-2022 236 30 a.m. a.m. PROPN admet-2022 236 31 alanazi alanazi PROPN admet-2022 236 32 , , PUNCT admet-2022 236 33 m.d m.d PROPN admet-2022 236 34 . . PROPN admet-2022 236 35 hussain hussain PROPN admet-2022 236 36 . . PUNCT admet-2022 237 1 evaluation evaluation NOUN admet-2022 237 2 of of ADP admet-2022 237 3 self self NOUN admet-2022 237 4 - - PUNCT admet-2022 237 5 nanoemulsifying nanoemulsifye VERB admet-2022 237 6 drug drug NOUN admet-2022 237 7 delivery delivery NOUN admet-2022 237 8 systems system NOUN admet-2022 237 9 ( ( PUNCT admet-2022 237 10 snedds snedds PROPN admet-2022 237 11 ) ) PUNCT admet-2022 237 12 for for ADP admet-2022 237 13 poorly poorly ADV admet-2022 237 14 water water NOUN admet-2022 237 15 - - PUNCT admet-2022 237 16 soluble soluble ADJ admet-2022 237 17 talinolol talinolol NOUN admet-2022 237 18 : : PUNCT admet-2022 237 19 preparation preparation NOUN admet-2022 237 20 , , PUNCT admet-2022 237 21 in in ADP admet-2022 237 22 vitro vitro X admet-2022 237 23 and and CCONJ admet-2022 237 24 in in ADP admet-2022 237 25 vivo vivo ADJ admet-2022 237 26 assessment assessment NOUN admet-2022 237 27 . . PUNCT admet-2022 238 1 frontiers frontier NOUN admet-2022 238 2 in in ADP admet-2022 238 3 pharmacology pharmacology NOUN admet-2022 238 4 10 10 NUM admet-2022 238 5 ( ( PUNCT admet-2022 238 6 2019 2019 NUM admet-2022 238 7 ) ) PUNCT admet-2022 238 8 459 459 NUM admet-2022 238 9 . . PUNCT admet-2022 239 1 https://doi.org/10.3389/fphar.2019.00459 https://doi.org/10.3389/fphar.2019.00459 PROPN admet-2022 239 2 . . PUNCT admet-2022 240 1 [ [ X admet-2022 240 2 28 28 NUM admet-2022 240 3 ] ] PUNCT admet-2022 240 4 a. a. NOUN admet-2022 240 5 khames khame NOUN admet-2022 240 6 . . PUNCT admet-2022 241 1 formulation formulation NOUN admet-2022 241 2 and and CCONJ admet-2022 241 3 characterization characterization NOUN admet-2022 241 4 of of ADP admet-2022 241 5 eplerenone eplerenone NOUN admet-2022 241 6 nanoemulsion nanoemulsion NOUN admet-2022 241 7 liquisolids liquisolid NOUN admet-2022 241 8 , , PUNCT admet-2022 241 9 an an DET admet-2022 241 10 oral oral ADJ admet-2022 241 11 delivery delivery NOUN admet-2022 241 12 system system NOUN admet-2022 241 13 with with ADP admet-2022 241 14 higher high ADJ admet-2022 241 15 release release NOUN admet-2022 241 16 rate rate NOUN admet-2022 241 17 and and CCONJ admet-2022 241 18 improved improved ADJ admet-2022 241 19 bioavailability bioavailability NOUN admet-2022 241 20 . . PUNCT admet-2022 242 1 pharmaceutics pharmaceutic NOUN admet-2022 242 2 11 11 NUM admet-2022 242 3 ( ( PUNCT admet-2022 242 4 2019 2019 NUM admet-2022 242 5 ) ) PUNCT admet-2022 242 6 40 40 NUM admet-2022 242 7 . . PUNCT admet-2022 243 1 https://doi.org/10.3390/pharmaceutics11010040 https://doi.org/10.3390/pharmaceutics11010040 NOUN admet-2022 243 2 . . PUNCT admet-2022 244 1 [ [ X admet-2022 244 2 29 29 NUM admet-2022 244 3 ] ] X admet-2022 244 4 u. u. PROPN admet-2022 244 5 farooq farooq PROPN admet-2022 244 6 , , PUNCT admet-2022 244 7 m.t m.t PROPN admet-2022 244 8 . . PROPN admet-2022 244 9 tweheyo tweheyo PROPN admet-2022 244 10 , , PUNCT admet-2022 244 11 j. j. PROPN admet-2022 244 12 sjöblom sjöblom PROPN admet-2022 244 13 , , PUNCT admet-2022 244 14 g. g. PROPN admet-2022 244 15 øye øye PROPN admet-2022 244 16 . . PUNCT admet-2022 245 1 surface surface NOUN admet-2022 245 2 characterization characterization NOUN admet-2022 245 3 of of ADP admet-2022 245 4 model model NOUN admet-2022 245 5 , , PUNCT admet-2022 245 6 outcrop outcrop NOUN admet-2022 245 7 , , PUNCT admet-2022 245 8 and and CCONJ admet-2022 245 9 reservoir reservoir NOUN admet-2022 245 10 samples sample NOUN admet-2022 245 11 in in ADP admet-2022 245 12 low low ADJ admet-2022 245 13 salinity salinity NOUN admet-2022 245 14 aqueous aqueous ADJ admet-2022 245 15 solutions solution NOUN admet-2022 245 16 . . PUNCT admet-2022 246 1 journal journal NOUN admet-2022 246 2 of of ADP admet-2022 246 3 dispersion dispersion NOUN admet-2022 246 4 science science NOUN admet-2022 246 5 and and CCONJ admet-2022 246 6 technology technology NOUN admet-2022 246 7 32 32 NUM admet-2022 246 8 ( ( PUNCT admet-2022 246 9 2011 2011 NUM admet-2022 246 10 ) ) PUNCT admet-2022 246 11 519 519 NUM admet-2022 246 12 - - SYM admet-2022 246 13 531 531 NUM admet-2022 246 14 . . PUNCT admet-2022 247 1 https://doi.org/10.1080/01932691003756936 https://doi.org/10.1080/01932691003756936 X admet-2022 247 2 . . PUNCT admet-2022 248 1 [ [ X admet-2022 248 2 30 30 NUM admet-2022 248 3 ] ] X admet-2022 248 4 l. l. PROPN admet-2022 248 5 du du PROPN admet-2022 248 6 , , PUNCT admet-2022 248 7 j. j. PROPN admet-2022 248 8 wang wang PROPN admet-2022 248 9 , , PUNCT admet-2022 248 10 y. y. PROPN admet-2022 248 11 zhang zhang PROPN admet-2022 248 12 , , PUNCT admet-2022 248 13 c. c. PROPN admet-2022 248 14 qi qi PROPN admet-2022 248 15 , , PUNCT admet-2022 248 16 m.p m.p PROPN admet-2022 248 17 . . PROPN admet-2022 248 18 wolcott wolcott PROPN admet-2022 248 19 , , PUNCT admet-2022 248 20 z. z. PROPN admet-2022 248 21 yu yu PROPN admet-2022 248 22 . . PUNCT admet-2022 249 1 preparation preparation NOUN admet-2022 249 2 and and CCONJ admet-2022 249 3 characterization characterization NOUN admet-2022 249 4 of of ADP admet-2022 249 5 cellulose cellulose NOUN admet-2022 249 6 nanocrystals nanocrystal NOUN admet-2022 249 7 from from ADP admet-2022 249 8 the the DET admet-2022 249 9 bio bio ADJ admet-2022 249 10 - - ADJ admet-2022 249 11 ethanol ethanol NOUN admet-2022 249 12 residuals residual NOUN admet-2022 249 13 . . PUNCT admet-2022 250 1 nanomaterials nanomaterial NOUN admet-2022 250 2 7 7 NUM admet-2022 250 3 ( ( PUNCT admet-2022 250 4 2017 2017 NUM admet-2022 250 5 ) ) PUNCT admet-2022 250 6 51 51 NUM admet-2022 250 7 . . PUNCT admet-2022 250 8 https://doi.org/10.3390/nano7030051 https://doi.org/10.3390/nano7030051 PROPN admet-2022 250 9 . . PUNCT admet-2022 251 1 [ [ X admet-2022 251 2 31 31 NUM admet-2022 251 3 ] ] PUNCT admet-2022 251 4 a. a. NOUN admet-2022 251 5 kaur kaur PROPN admet-2022 251 6 , , PUNCT admet-2022 251 7 p.k p.k PROPN admet-2022 251 8 . . PROPN admet-2022 251 9 parmar parmar PROPN admet-2022 251 10 , , PUNCT admet-2022 251 11 a.k a.k PROPN admet-2022 251 12 . . PROPN admet-2022 251 13 bansal bansal NOUN admet-2022 251 14 . . PUNCT admet-2022 252 1 evaluation evaluation NOUN admet-2022 252 2 of of ADP admet-2022 252 3 different different ADJ admet-2022 252 4 techniques technique NOUN admet-2022 252 5 for for ADP admet-2022 252 6 size size NOUN admet-2022 252 7 determination determination NOUN admet-2022 252 8 of of ADP admet-2022 252 9 drug drug NOUN admet-2022 252 10 nanocrystals nanocrystal NOUN admet-2022 252 11 : : PUNCT admet-2022 252 12 a a DET admet-2022 252 13 case case NOUN admet-2022 252 14 study study NOUN admet-2022 252 15 of of ADP admet-2022 252 16 celecoxib celecoxib VERB admet-2022 252 17 nanocrystalline nanocrystalline ADJ admet-2022 252 18 solid solid ADJ admet-2022 252 19 dispersion dispersion NOUN admet-2022 252 20 . . PUNCT admet-2022 253 1 pharmaceutics pharmaceutic NOUN admet-2022 253 2 11 11 NUM admet-2022 253 3 ( ( PUNCT admet-2022 253 4 2019 2019 NUM admet-2022 253 5 ) ) PUNCT admet-2022 253 6 516 516 NUM admet-2022 253 7 . . PUNCT admet-2022 254 1 https://doi.org/10.3390/pharmaceutics11100516 https://doi.org/10.3390/pharmaceutics11100516 ADJ admet-2022 254 2 . . PUNCT admet-2022 255 1 [ [ X admet-2022 255 2 32 32 NUM admet-2022 255 3 ] ] X admet-2022 255 4 c. c. PROPN admet-2022 255 5 bhagat bhagat PROPN admet-2022 255 6 , , PUNCT admet-2022 255 7 s.k s.k PROPN admet-2022 255 8 . . PROPN admet-2022 255 9 singh singh PROPN admet-2022 255 10 , , PUNCT admet-2022 255 11 p.r.p p.r.p NOUN admet-2022 255 12 . . PUNCT admet-2022 255 13 verma verma PROPN admet-2022 255 14 , , PUNCT admet-2022 255 15 n. n. PROPN admet-2022 255 16 singh singh PROPN admet-2022 255 17 , , PUNCT admet-2022 255 18 s. s. PROPN admet-2022 255 19 verma verma PROPN admet-2022 255 20 , , PUNCT admet-2022 255 21 m.n m.n PROPN admet-2022 255 22 . . PROPN admet-2022 255 23 ahsan ahsan PROPN admet-2022 255 24 . . PUNCT admet-2022 256 1 crystalline crystalline NOUN admet-2022 256 2 and and CCONJ admet-2022 256 3 amorphous amorphous ADJ admet-2022 256 4 carvedilol carvedilol NOUN admet-2022 256 5 - - PUNCT admet-2022 256 6 loaded load VERB admet-2022 256 7 nanoemulsions nanoemulsion NOUN admet-2022 256 8 : : PUNCT admet-2022 256 9 formulation formulation NOUN admet-2022 256 10 optimisation optimisation NOUN admet-2022 256 11 using use VERB admet-2022 256 12 response response NOUN admet-2022 256 13 surface surface NOUN admet-2022 256 14 methodology methodology NOUN admet-2022 256 15 . . PUNCT admet-2022 257 1 journal journal PROPN admet-2022 257 2 of of ADP admet-2022 257 3 experimental experimental ADJ admet-2022 257 4 nanoscience nanoscience NOUN admet-2022 257 5 8 8 NUM admet-2022 257 6 ( ( PUNCT admet-2022 257 7 2013 2013 NUM admet-2022 257 8 ) ) PUNCT admet-2022 257 9 971 971 NUM admet-2022 257 10 - - SYM admet-2022 257 11 992 992 NUM admet-2022 257 12 . . PUNCT admet-2022 258 1 https://doi.org/10.1080/17458080.2011.630037 https://doi.org/10.1080/17458080.2011.630037 NOUN admet-2022 258 2 . . PUNCT admet-2022 259 1 [ [ X admet-2022 259 2 33 33 NUM admet-2022 259 3 ] ] PUNCT admet-2022 259 4 j. j. PROPN admet-2022 259 5 wei wei PROPN admet-2022 259 6 , , PUNCT admet-2022 259 7 j. j. PROPN admet-2022 259 8 zhang zhang PROPN admet-2022 259 9 , , PUNCT admet-2022 259 10 l. l. PROPN admet-2022 259 11 wang wang PROPN admet-2022 259 12 , , PUNCT admet-2022 259 13 b.j b.j PROPN admet-2022 259 14 . . PROPN admet-2022 259 15 cha cha PROPN admet-2022 259 16 , , PUNCT admet-2022 259 17 s. s. PROPN admet-2022 259 18 jiang jiang PROPN admet-2022 259 19 , , PUNCT admet-2022 259 20 r. r. PROPN admet-2022 259 21 liu liu PROPN admet-2022 259 22 . . PUNCT admet-2022 260 1 a a DET admet-2022 260 2 new new ADJ admet-2022 260 3 low low ADJ admet-2022 260 4 - - PUNCT admet-2022 260 5 nephron nephron NOUN admet-2022 260 6 ckd ckd NOUN admet-2022 260 7 model model NOUN admet-2022 260 8 with with ADP admet-2022 260 9 hypertension hypertension NOUN admet-2022 260 10 , , PUNCT admet-2022 260 11 progressive progressive ADJ admet-2022 260 12 decline decline NOUN admet-2022 260 13 of of ADP admet-2022 260 14 renal renal ADJ admet-2022 260 15 function function NOUN admet-2022 260 16 , , PUNCT admet-2022 260 17 and and CCONJ admet-2022 260 18 enhanced enhance VERB admet-2022 260 19 inflammation inflammation NOUN admet-2022 260 20 in in ADP admet-2022 260 21 c57bl/6 c57bl/6 NOUN admet-2022 260 22 mice mouse NOUN admet-2022 260 23 . . 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