id	sid	tid	token	lemma	pos
admet-2042	1	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	1	2	evaluation	evaluation	NOUN
admet-2042	1	3	of	of	ADP
admet-2042	1	4	newly	newly	ADV
admet-2042	1	5	formulated	formulate	VERB
admet-2042	1	6	beads	bead	NOUN
admet-2042	1	7	alginate	alginate	NOUN
admet-2042	1	8	/	/	SYM
admet-2042	1	9	gum	gum	NOUN
admet-2042	1	10	acacia	acacia	NOUN
admet-2042	1	11	loaded	load	VERB
admet-2042	1	12	ketoconazole	ketoconazole	NOUN
admet-2042	1	13	in	in	ADP
admet-2042	1	14	rabbit	rabbit	NOUN
admet-2042	1	15	plasma	plasma	NOUN
admet-2042	1	16	by	by	ADP
admet-2042	1	17	oral	oral	ADJ
admet-2042	1	18	administration	administration	NOUN
admet-2042	1	19	doi	doi	PROPN
admet-2042	1	20	:	:	PUNCT
admet-2042	1	21	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	NOUN
admet-2042	1	22	335	335	NUM
admet-2042	1	23	admet	admet	X
admet-2042	1	24	&	&	CCONJ
admet-2042	1	25	dmpk	dmpk	PROPN
admet-2042	1	26	12(2	12(2	NUM
admet-2042	1	27	)	)	PUNCT
admet-2042	1	28	(	(	PUNCT
admet-2042	1	29	2024	2024	NUM
admet-2042	1	30	)	)	PUNCT
admet-2042	1	31	335	335	NUM
admet-2042	1	32	-	-	SYM
admet-2042	1	33	341	341	NUM
admet-2042	1	34	;	;	PUNCT
admet-2042	1	35	doi	doi	NOUN
admet-2042	1	36	:	:	PUNCT
admet-2042	1	37	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	NOUN
admet-2042	1	38	open	open	ADJ
admet-2042	1	39	access	access	NOUN
admet-2042	1	40	:	:	PUNCT
admet-2042	1	41	issn	issn	PROPN
admet-2042	1	42	:	:	PUNCT
admet-2042	1	43	1848	1848	NUM
admet-2042	1	44	-	-	SYM
admet-2042	1	45	7718	7718	NUM
admet-2042	1	46	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2042	1	47	original	original	ADJ
admet-2042	1	48	scientific	scientific	ADJ
admet-2042	1	49	paper	paper	NOUN
admet-2042	1	50	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	1	51	evaluation	evaluation	NOUN
admet-2042	1	52	of	of	ADP
admet-2042	1	53	newly	newly	ADV
admet-2042	1	54	formulated	formulate	VERB
admet-2042	1	55	beads	bead	NOUN
admet-2042	1	56	alginate	alginate	NOUN
admet-2042	1	57	/	/	SYM
admet-2042	1	58	gum	gum	NOUN
admet-2042	1	59	acacia	acacia	NOUN
admet-2042	1	60	loaded	load	VERB
admet-2042	1	61	ketoconazole	ketoconazole	NOUN
admet-2042	1	62	in	in	ADP
admet-2042	1	63	rabbit	rabbit	NOUN
admet-2042	1	64	plasma	plasma	NOUN
admet-2042	1	65	by	by	ADP
admet-2042	1	66	oral	oral	ADJ
admet-2042	1	67	administration	administration	NOUN
admet-2042	1	68	viviane	viviane	PROPN
admet-2042	1	69	annisa1	annisa1	NOUN
admet-2042	1	70	,	,	PUNCT
admet-2042	1	71	teuku	teuku	PRON
admet-2042	1	72	nanda	nanda	ADV
admet-2042	1	73	saifullah	saifullah	VERB
admet-2042	1	74	sulaiman2	sulaiman2	PROPN
admet-2042	1	75	,	,	PUNCT
admet-2042	1	76	akhmad	akhmad	PROPN
admet-2042	1	77	kharis	kharis	VERB
admet-2042	1	78	nugroho2	nugroho2	ADV
admet-2042	1	79	and	and	CCONJ
admet-2042	1	80	agung	agung	PROPN
admet-2042	1	81	endro	endro	PROPN
admet-2042	1	82	nugroho3	nugroho3	PROPN
admet-2042	1	83	,	,	PUNCT
admet-2042	1	84	*	*	PROPN
admet-2042	1	85	1program	1program	NUM
admet-2042	1	86	doctoral	doctoral	ADJ
admet-2042	1	87	faculty	faculty	NOUN
admet-2042	1	88	of	of	ADP
admet-2042	1	89	pharmacy	pharmacy	NOUN
admet-2042	1	90	,	,	PUNCT
admet-2042	1	91	universitas	universita	NOUN
admet-2042	1	92	gadjah	gadjah	PROPN
admet-2042	1	93	mada	mada	PROPN
admet-2042	1	94	,	,	PUNCT
admet-2042	1	95	indonesia	indonesia	PROPN
admet-2042	1	96	2departement	2departement	NUM
admet-2042	1	97	of	of	ADP
admet-2042	1	98	pharmaceutics	pharmaceutic	NOUN
admet-2042	1	99	,	,	PUNCT
admet-2042	1	100	faculty	faculty	NOUN
admet-2042	1	101	of	of	ADP
admet-2042	1	102	pharmacy	pharmacy	NOUN
admet-2042	1	103	,	,	PUNCT
admet-2042	1	104	universitas	universita	NOUN
admet-2042	1	105	gadjah	gadjah	PROPN
admet-2042	1	106	mada	mada	PROPN
admet-2042	1	107	,	,	PUNCT
admet-2042	1	108	indonesia	indonesia	PROPN
admet-2042	1	109	3departement	3departement	NUM
admet-2042	1	110	of	of	ADP
admet-2042	1	111	pharmacology	pharmacology	NOUN
admet-2042	1	112	and	and	CCONJ
admet-2042	1	113	clinical	clinical	ADJ
admet-2042	1	114	pharmacy	pharmacy	NOUN
admet-2042	1	115	,	,	PUNCT
admet-2042	1	116	faculty	faculty	NOUN
admet-2042	1	117	of	of	ADP
admet-2042	1	118	pharmacy	pharmacy	NOUN
admet-2042	1	119	,	,	PUNCT
admet-2042	1	120	universitas	universita	NOUN
admet-2042	1	121	gadjah	gadjah	PROPN
admet-2042	1	122	mada	mada	PROPN
admet-2042	1	123	,	,	PUNCT
admet-2042	1	124	indonesia	indonesia	PROPN
admet-2042	1	125	*	*	PUNCT
admet-2042	1	126	corresponding	correspond	VERB
admet-2042	1	127	author	author	NOUN
admet-2042	1	128	:	:	PUNCT
admet-2042	1	129	e	e	NOUN
admet-2042	1	130	-	-	NOUN
admet-2042	1	131	mail	mail	NOUN
admet-2042	1	132	:	:	PUNCT
admet-2042	1	133	nugroho_ae@ugm.ac.id	nugroho_ae@ugm.ac.id	ADJ
admet-2042	1	134	,	,	PUNCT
admet-2042	1	135	tel	tel	PROPN
admet-2042	1	136	.	.	PUNCT
admet-2042	2	1	:	:	PUNCT
admet-2042	2	2	+62	+62	PROPN
admet-2042	2	3	85643929723	85643929723	NUM
admet-2042	2	4	received	receive	VERB
admet-2042	2	5	:	:	PUNCT
admet-2042	2	6	august	august	PROPN
admet-2042	2	7	22	22	NUM
admet-2042	2	8	,	,	PUNCT
admet-2042	2	9	2023	2023	NUM
admet-2042	2	10	;	;	PUNCT
admet-2042	2	11	revised	revise	VERB
admet-2042	2	12	:	:	PUNCT
admet-2042	2	13	november	november	PROPN
admet-2042	2	14	19	19	NUM
admet-2042	2	15	,	,	PUNCT
admet-2042	2	16	2023	2023	NUM
admet-2042	2	17	;	;	PUNCT
admet-2042	2	18	published	publish	VERB
admet-2042	2	19	:	:	PUNCT
admet-2042	2	20	november	november	PROPN
admet-2042	2	21	30	30	NUM
admet-2042	2	22	,	,	PUNCT
admet-2042	2	23	2023	2023	NUM
admet-2042	2	24	abstract	abstract	ADJ
admet-2042	2	25	background	background	NOUN
admet-2042	2	26	and	and	CCONJ
admet-2042	2	27	purporse	purporse	NOUN
admet-2042	2	28	:	:	PUNCT
admet-2042	2	29	the	the	DET
admet-2042	2	30	combination	combination	NOUN
admet-2042	2	31	of	of	ADP
admet-2042	2	32	alginate	alginate	NOUN
admet-2042	2	33	and	and	CCONJ
admet-2042	2	34	gum	gum	NOUN
admet-2042	2	35	acacia	acacia	NOUN
admet-2042	2	36	in	in	ADP
admet-2042	2	37	previous	previous	ADJ
admet-2042	2	38	studies	study	NOUN
admet-2042	2	39	showed	show	VERB
admet-2042	2	40	good	good	ADJ
admet-2042	2	41	results	result	NOUN
admet-2042	2	42	in	in	ADP
admet-2042	2	43	inhibiting	inhibit	VERB
admet-2042	2	44	ketoconazole	ketoconazole	NOUN
admet-2042	2	45	precipitation	precipitation	NOUN
admet-2042	2	46	due	due	ADP
admet-2042	2	47	to	to	ADP
admet-2042	2	48	the	the	DET
admet-2042	2	49	supersaturation	supersaturation	NOUN
admet-2042	2	50	phenomenon	phenomenon	NOUN
admet-2042	2	51	.	.	PUNCT
admet-2042	3	1	ketoconazole	ketoconazole	NOUN
admet-2042	3	2	-	-	PUNCT
admet-2042	3	3	loaded	load	VERB
admet-2042	3	4	alginate	alginate	NOUN
admet-2042	3	5	and	and	CCONJ
admet-2042	3	6	gum	gum	NOUN
admet-2042	3	7	acacia	acacia	NOUN
admet-2042	3	8	can	can	AUX
admet-2042	3	9	produce	produce	VERB
admet-2042	3	10	hydrogel	hydrogel	NOUN
admet-2042	3	11	beads	bead	NOUN
admet-2042	3	12	through	through	ADP
admet-2042	3	13	cross	cross	NOUN
admet-2042	3	14	-	-	ADJ
admet-2042	3	15	linking	link	VERB
admet-2042	3	16	with	with	ADP
admet-2042	3	17	ca2	ca2	PROPN
admet-2042	3	18	+	+	PROPN
admet-2042	3	19	using	use	VERB
admet-2042	3	20	ionotropic	ionotropic	ADJ
admet-2042	3	21	gelation	gelation	NOUN
admet-2042	3	22	techniques	technique	NOUN
admet-2042	3	23	.	.	PUNCT
admet-2042	4	1	however	however	ADV
admet-2042	4	2	,	,	PUNCT
admet-2042	4	3	the	the	DET
admet-2042	4	4	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	4	5	study	study	NOUN
admet-2042	4	6	of	of	ADP
admet-2042	4	7	the	the	DET
admet-2042	4	8	ketoconazole	ketoconazole	NOUN
admet-2042	4	9	beads	bead	NOUN
admet-2042	4	10	loaded	load	VERB
admet-2042	4	11	to	to	PART
admet-2042	4	12	alginate	alginate	VERB
admet-2042	4	13	and	and	CCONJ
admet-2042	4	14	gum	gum	NOUN
admet-2042	4	15	acacia	acacia	NOUN
admet-2042	4	16	needs	need	VERB
admet-2042	4	17	further	further	ADJ
admet-2042	4	18	investigation	investigation	NOUN
admet-2042	4	19	.	.	PUNCT
admet-2042	5	1	this	this	DET
admet-2042	5	2	study	study	NOUN
admet-2042	5	3	aimed	aim	VERB
admet-2042	5	4	to	to	PART
admet-2042	5	5	evaluate	evaluate	VERB
admet-2042	5	6	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	5	7	parameters	parameter	NOUN
admet-2042	5	8	using	use	VERB
admet-2042	5	9	rabbits	rabbit	NOUN
admet-2042	5	10	via	via	ADP
admet-2042	5	11	oral	oral	ADJ
admet-2042	5	12	administration	administration	NOUN
admet-2042	5	13	.	.	PUNCT
admet-2042	6	1	experimental	experimental	ADJ
admet-2042	6	2	approach	approach	NOUN
admet-2042	6	3	:	:	PUNCT
admet-2042	6	4	the	the	DET
admet-2042	6	5	drug	drug	NOUN
admet-2042	6	6	was	be	AUX
admet-2042	6	7	administered	administer	VERB
admet-2042	6	8	orally	orally	ADV
admet-2042	6	9	to	to	ADP
admet-2042	6	10	2	2	NUM
admet-2042	6	11	groups	group	NOUN
admet-2042	6	12	of	of	ADP
admet-2042	6	13	rabbits	rabbit	NOUN
admet-2042	6	14	:	:	PUNCT
admet-2042	6	15	pure	pure	ADJ
admet-2042	6	16	ketoconazole	ketoconazole	NOUN
admet-2042	6	17	(	(	PUNCT
admet-2042	6	18	ktz	ktz	PROPN
admet-2042	6	19	)	)	PUNCT
admet-2042	6	20	and	and	CCONJ
admet-2042	6	21	formulation	formulation	NOUN
admet-2042	6	22	of	of	ADP
admet-2042	6	23	ketoconazole	ketoconazole	NOUN
admet-2042	6	24	(	(	PUNCT
admet-2042	6	25	ag75	ag75	PROPN
admet-2042	6	26	)	)	PUNCT
admet-2042	6	27	groups	group	NOUN
admet-2042	6	28	.	.	PUNCT
admet-2042	7	1	blood	blood	NOUN
admet-2042	7	2	samples	sample	NOUN
admet-2042	7	3	were	be	AUX
admet-2042	7	4	obtained	obtain	VERB
admet-2042	7	5	from	from	ADP
admet-2042	7	6	the	the	DET
admet-2042	7	7	ear	ear	NOUN
admet-2042	7	8	marginal	marginal	ADJ
admet-2042	7	9	vein	vein	NOUN
admet-2042	7	10	at	at	ADP
admet-2042	7	11	various	various	ADJ
admet-2042	7	12	time	time	NOUN
admet-2042	7	13	points	point	NOUN
admet-2042	7	14	:	:	PUNCT
admet-2042	7	15	0	0	NUM
admet-2042	8	1	(	(	PUNCT
admet-2042	8	2	before	before	ADP
admet-2042	8	3	administration	administration	NOUN
admet-2042	8	4	)	)	PUNCT
admet-2042	8	5	,	,	PUNCT
admet-2042	8	6	15	15	NUM
admet-2042	8	7	,	,	PUNCT
admet-2042	8	8	30	30	NUM
admet-2042	8	9	,	,	PUNCT
admet-2042	8	10	45	45	NUM
admet-2042	8	11	,	,	PUNCT
admet-2042	8	12	60	60	NUM
admet-2042	8	13	,	,	PUNCT
admet-2042	8	14	90	90	NUM
admet-2042	8	15	,	,	PUNCT
admet-2042	8	16	120	120	NUM
admet-2042	8	17	,	,	PUNCT
admet-2042	8	18	150	150	NUM
admet-2042	8	19	,	,	PUNCT
admet-2042	8	20	180	180	NUM
admet-2042	8	21	,	,	PUNCT
admet-2042	8	22	240	240	NUM
admet-2042	8	23	,	,	PUNCT
admet-2042	8	24	300	300	NUM
admet-2042	8	25	,	,	PUNCT
admet-2042	8	26	360	360	NUM
admet-2042	8	27	,	,	PUNCT
admet-2042	8	28	and	and	CCONJ
admet-2042	8	29	420	420	NUM
admet-2042	8	30	minutes	minute	NOUN
admet-2042	8	31	after	after	ADP
admet-2042	8	32	oral	oral	ADJ
admet-2042	8	33	dosage	dosage	NOUN
admet-2042	8	34	.	.	PUNCT
admet-2042	9	1	the	the	DET
admet-2042	9	2	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	9	3	study	study	NOUN
admet-2042	9	4	employed	employ	VERB
admet-2042	9	5	a	a	DET
admet-2042	9	6	non	non	ADJ
admet-2042	9	7	-	-	ADJ
admet-2042	9	8	compartment	compartment	ADJ
admet-2042	9	9	analysis	analysis	NOUN
admet-2042	9	10	to	to	PART
admet-2042	9	11	calculate	calculate	VERB
admet-2042	9	12	the	the	DET
admet-2042	9	13	area	area	NOUN
admet-2042	9	14	under	under	ADP
admet-2042	9	15	the	the	DET
admet-2042	9	16	curve	curve	NOUN
admet-2042	9	17	(	(	PUNCT
admet-2042	9	18	auc	auc	NOUN
admet-2042	9	19	)	)	PUNCT
admet-2042	9	20	,	,	PUNCT
admet-2042	9	21	the	the	DET
admet-2042	9	22	volume	volume	NOUN
admet-2042	9	23	of	of	ADP
admet-2042	9	24	distribution	distribution	NOUN
admet-2042	9	25	(	(	PUNCT
admet-2042	9	26	vd	vd	NOUN
admet-2042	9	27	f-1	f-1	NOUN
admet-2042	9	28	)	)	PUNCT
admet-2042	9	29	,	,	PUNCT
admet-2042	9	30	clearance	clearance	NOUN
admet-2042	9	31	(	(	PUNCT
admet-2042	9	32	cl	cl	NOUN
admet-2042	9	33	f-1	f-1	NOUN
admet-2042	9	34	)	)	PUNCT
admet-2042	9	35	,	,	PUNCT
admet-2042	9	36	maximum	maximum	ADJ
admet-2042	9	37	concentration	concentration	NOUN
admet-2042	9	38	(	(	PUNCT
admet-2042	9	39	cmax	cmax	NOUN
admet-2042	9	40	)	)	PUNCT
admet-2042	9	41	,	,	PUNCT
admet-2042	9	42	and	and	CCONJ
admet-2042	9	43	time	time	NOUN
admet-2042	9	44	to	to	PART
admet-2042	9	45	reach	reach	VERB
admet-2042	9	46	maximum	maximum	ADJ
admet-2042	9	47	concentration	concentration	NOUN
admet-2042	9	48	(	(	PUNCT
admet-2042	9	49	tmax	tmax	ADJ
admet-2042	9	50	)	)	PUNCT
admet-2042	9	51	.	.	PUNCT
admet-2042	10	1	the	the	DET
admet-2042	10	2	data	datum	NOUN
admet-2042	10	3	obtained	obtain	VERB
admet-2042	10	4	from	from	ADP
admet-2042	10	5	the	the	DET
admet-2042	10	6	parameter	parameter	NOUN
admet-2042	10	7	result	result	NOUN
admet-2042	10	8	was	be	AUX
admet-2042	10	9	analyzed	analyze	VERB
admet-2042	10	10	using	use	VERB
admet-2042	10	11	the	the	DET
admet-2042	10	12	independent	independent	ADJ
admet-2042	10	13	-	-	PUNCT
admet-2042	10	14	sample	sample	NOUN
admet-2042	10	15	t	t	NOUN
admet-2042	10	16	-	-	PUNCT
admet-2042	10	17	test	test	NOUN
admet-2042	10	18	.	.	PUNCT
admet-2042	11	1	key	key	ADJ
admet-2042	11	2	result	result	NOUN
admet-2042	11	3	:	:	PUNCT
admet-2042	11	4	the	the	DET
admet-2042	11	5	results	result	NOUN
admet-2042	11	6	of	of	ADP
admet-2042	11	7	the	the	DET
admet-2042	11	8	ktz	ktz	PROPN
admet-2042	11	9	group	group	NOUN
admet-2042	11	10	include	include	VERB
admet-2042	11	11	auc	auc	NOUN
admet-2042	11	12	of	of	ADP
admet-2042	11	13	15.83±0.62	15.83±0.62	NUM
admet-2042	11	14	h	h	NOUN
admet-2042	11	15	µg	µg	ADP
admet-2042	11	16	ml-1	ml-1	X
admet-2042	11	17	,	,	PUNCT
admet-2042	11	18	vdf-1	vdf-1	X
admet-2042	11	19	of	of	ADP
admet-2042	11	20	8.95±1.17	8.95±1.17	PROPN
admet-2042	11	21	ml	ml	NOUN
admet-2042	11	22	,	,	PUNCT
admet-2042	11	23	clf-1	clf-1	NUM
admet-2042	11	24	of	of	ADP
admet-2042	11	25	3.45±0.3	3.45±0.3	NUM
admet-2042	11	26	ml	ml	NOUN
admet-2042	11	27	h-1	h-1	NOUN
admet-2042	11	28	,	,	PUNCT
admet-2042	11	29	cmax	cmax	NOUN
admet-2042	11	30	of	of	ADP
admet-2042	11	31	4.7±0.69	4.7±0.69	NUM
admet-2042	11	32	µg	µg	ADV
admet-2042	11	33	ml-1	ml-1	X
admet-2042	11	34	,	,	PUNCT
admet-2042	11	35	and	and	CCONJ
admet-2042	11	36	tmax	tmax	ADP
admet-2042	11	37	of	of	ADP
admet-2042	11	38	1.67±0.17	1.67±0.17	PROPN
admet-2042	11	39	h.	h.	NOUN
admet-2042	11	40	the	the	DET
admet-2042	11	41	results	result	NOUN
admet-2042	11	42	of	of	ADP
admet-2042	11	43	the	the	DET
admet-2042	11	44	ag75	ag75	PROPN
admet-2042	11	45	group	group	NOUN
admet-2042	11	46	include	include	VERB
admet-2042	11	47	auc	auc	NOUN
admet-2042	11	48	of	of	ADP
admet-2042	11	49	27.8±1.01	27.8±1.01	NUM
admet-2042	11	50	h	h	NOUN
admet-2042	11	51	µg	µg	ADV
admet-2042	11	52	ml-1	ml-1	X
admet-2042	11	53	,	,	PUNCT
admet-2042	11	54	vdf-1	vdf-1	X
admet-2042	11	55	of	of	ADP
admet-2042	11	56	11.5±2.4	11.5±2.4	NUM
admet-2042	11	57	ml	ml	NOUN
admet-2042	11	58	,	,	PUNCT
admet-2042	11	59	clf-1	clf-1	NUM
admet-2042	11	60	of	of	ADP
admet-2042	11	61	2.15±0.11	2.15±0.11	NUM
admet-2042	11	62	ml	ml	NOUN
admet-2042	11	63	h-1	h-1	NOUN
admet-2042	11	64	,	,	PUNCT
admet-2042	11	65	cmax	cmax	NOUN
admet-2042	11	66	of	of	ADP
admet-2042	11	67	4.49±0.52	4.49±0.52	NOUN
admet-2042	11	68	µg	µg	ADV
admet-2042	11	69	ml-1	ml-1	X
admet-2042	11	70	,	,	PUNCT
admet-2042	11	71	and	and	CCONJ
admet-2042	11	72	tmax	tmax	ADP
admet-2042	11	73	of	of	ADP
admet-2042	11	74	2.5±0.5	2.5±0.5	NUM
admet-2042	11	75	h.	h.	NOUN
admet-2042	11	76	conclusion	conclusion	NOUN
admet-2042	11	77	:	:	PUNCT
admet-2042	11	78	the	the	DET
admet-2042	11	79	formulation	formulation	NOUN
admet-2042	11	80	incorporating	incorporate	VERB
admet-2042	11	81	ketoconazole	ketoconazole	NOUN
admet-2042	11	82	beads	bead	NOUN
admet-2042	11	83	resulted	result	VERB
admet-2042	11	84	in	in	ADP
admet-2042	11	85	a	a	DET
admet-2042	11	86	higher	high	ADJ
admet-2042	11	87	auc0-∞	auc0-∞	NUM
admet-2042	11	88	than	than	ADP
admet-2042	11	89	the	the	DET
admet-2042	11	90	pure	pure	ADJ
admet-2042	11	91	ketoconazole	ketoconazole	NOUN
admet-2042	11	92	.	.	PUNCT
admet-2042	12	1	this	this	DET
admet-2042	12	2	finding	finding	NOUN
admet-2042	12	3	suggests	suggest	VERB
admet-2042	12	4	that	that	SCONJ
admet-2042	12	5	the	the	DET
admet-2042	12	6	created	create	VERB
admet-2042	12	7	formulation	formulation	NOUN
admet-2042	12	8	has	have	AUX
admet-2042	12	9	enhanced	enhance	VERB
admet-2042	12	10	the	the	DET
admet-2042	12	11	bioavailability	bioavailability	NOUN
admet-2042	12	12	of	of	ADP
admet-2042	12	13	ketoconazole	ketoconazole	NOUN
admet-2042	12	14	.	.	PUNCT
admet-2042	13	1	©	©	PROPN
admet-2042	13	2	2023	2023	NUM
admet-2042	13	3	by	by	ADP
admet-2042	13	4	the	the	DET
admet-2042	13	5	authors	author	NOUN
admet-2042	13	6	.	.	PUNCT
admet-2042	14	1	this	this	DET
admet-2042	14	2	article	article	NOUN
admet-2042	14	3	is	be	AUX
admet-2042	14	4	an	an	DET
admet-2042	14	5	open	open	ADJ
admet-2042	14	6	-	-	PUNCT
admet-2042	14	7	access	access	NOUN
admet-2042	14	8	article	article	NOUN
admet-2042	14	9	distributed	distribute	VERB
admet-2042	14	10	under	under	ADP
admet-2042	14	11	the	the	DET
admet-2042	14	12	terms	term	NOUN
admet-2042	14	13	and	and	CCONJ
admet-2042	14	14	conditions	condition	NOUN
admet-2042	14	15	of	of	ADP
admet-2042	14	16	the	the	DET
admet-2042	14	17	creative	creative	ADJ
admet-2042	14	18	commons	common	NOUN
admet-2042	14	19	attribution	attribution	NOUN
admet-2042	14	20	license	license	NOUN
admet-2042	14	21	(	(	PUNCT
admet-2042	14	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2042	14	23	)	)	PUNCT
admet-2042	14	24	.	.	PUNCT
admet-2042	15	1	keywords	keyword	NOUN
admet-2042	15	2	in	in	ADP
admet-2042	15	3	vivo	vivo	NOUN
admet-2042	15	4	;	;	PUNCT
admet-2042	15	5	drug	drug	NOUN
admet-2042	15	6	;	;	PUNCT
admet-2042	15	7	bioavailability	bioavailability	NOUN
admet-2042	15	8	;	;	PUNCT
admet-2042	15	9	hydrogel	hydrogel	NOUN
admet-2042	15	10	;	;	PUNCT
admet-2042	15	11	polymer	polymer	NOUN
admet-2042	15	12	introduction	introduction	NOUN
admet-2042	15	13	ketoconazole	ketoconazole	NOUN
admet-2042	15	14	is	be	AUX
admet-2042	15	15	categorized	categorize	VERB
admet-2042	15	16	as	as	ADP
admet-2042	15	17	the	the	DET
admet-2042	15	18	biopharmaceutics	biopharmaceutics	NOUN
admet-2042	15	19	classification	classification	NOUN
admet-2042	15	20	system	system	NOUN
admet-2042	15	21	(	(	PUNCT
admet-2042	15	22	bcs	bcs	NOUN
admet-2042	15	23	)	)	PUNCT
admet-2042	15	24	class	class	NOUN
admet-2042	15	25	iib	iib	NOUN
admet-2042	15	26	due	due	ADP
admet-2042	15	27	to	to	ADP
admet-2042	15	28	its	its	PRON
admet-2042	15	29	limited	limited	ADJ
admet-2042	15	30	solubility	solubility	NOUN
admet-2042	15	31	.	.	PUNCT
admet-2042	16	1	the	the	DET
admet-2042	16	2	substance	substance	NOUN
admet-2042	16	3	's	's	PART
admet-2042	16	4	solubility	solubility	NOUN
admet-2042	16	5	increases	increase	VERB
admet-2042	16	6	in	in	ADP
admet-2042	16	7	acidic	acidic	ADJ
admet-2042	16	8	conditions	condition	NOUN
admet-2042	16	9	,	,	PUNCT
admet-2042	16	10	such	such	ADJ
admet-2042	16	11	as	as	ADP
admet-2042	16	12	low	low	ADJ
admet-2042	16	13	ph	ph	NOUN
admet-2042	16	14	or	or	CCONJ
admet-2042	16	15	the	the	DET
admet-2042	16	16	ph	ph	ADJ
admet-2042	16	17	range	range	NOUN
admet-2042	16	18	of	of	ADP
admet-2042	16	19	the	the	DET
admet-2042	16	20	stomach	stomach	NOUN
admet-2042	16	21	(	(	PUNCT
admet-2042	16	22	ph	ph	NOUN
admet-2042	16	23	1	1	NUM
admet-2042	16	24	to	to	ADP
admet-2042	16	25	3	3	NUM
admet-2042	16	26	)	)	PUNCT
admet-2042	17	1	[	[	X
admet-2042	17	2	1	1	NUM
admet-2042	17	3	]	]	PUNCT
admet-2042	17	4	.	.	PUNCT
admet-2042	18	1	on	on	ADP
admet-2042	18	2	the	the	DET
admet-2042	18	3	other	other	ADJ
admet-2042	18	4	hand	hand	NOUN
admet-2042	18	5	,	,	PUNCT
admet-2042	18	6	the	the	DET
admet-2042	18	7	solubility	solubility	NOUN
admet-2042	18	8	of	of	ADP
admet-2042	18	9	ketoconazole	ketoconazole	NOUN
admet-2042	18	10	will	will	AUX
admet-2042	18	11	decrease	decrease	VERB
admet-2042	18	12	under	under	ADP
admet-2042	18	13	alkaline	alkaline	NOUN
admet-2042	18	14	conditions	condition	NOUN
admet-2042	18	15	,	,	PUNCT
admet-2042	18	16	such	such	ADJ
admet-2042	18	17	as	as	ADP
admet-2042	18	18	the	the	DET
admet-2042	18	19	intestinal	intestinal	ADJ
admet-2042	18	20	ph	ph	ADJ
admet-2042	18	21	level	level	NOUN
admet-2042	18	22	[	[	X
admet-2042	18	23	2	2	NUM
admet-2042	18	24	]	]	PUNCT
admet-2042	18	25	.	.	PUNCT
admet-2042	19	1	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	PROPN
admet-2042	19	2	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	ADP
admet-2042	19	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2042	19	4	mailto:nugroho_ae@ugm.ac.id	mailto:nugroho_ae@ugm.ac.id	PROPN
admet-2042	19	5	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2042	19	6	v.	v.	ADP
admet-2042	19	7	annisa	annisa	ADP
admet-2042	19	8	et	et	PROPN
admet-2042	19	9	al	al	PROPN
admet-2042	19	10	.	.	PROPN
admet-2042	19	11	admet	admet	PROPN
admet-2042	19	12	&	&	CCONJ
admet-2042	19	13	dmpk	dmpk	PROPN
admet-2042	19	14	12(2	12(2	NUM
admet-2042	19	15	)	)	PUNCT
admet-2042	19	16	(	(	PUNCT
admet-2042	19	17	2024	2024	NUM
admet-2042	19	18	)	)	PUNCT
admet-2042	19	19	335	335	NUM
admet-2042	19	20	-	-	SYM
admet-2042	19	21	341	341	NUM
admet-2042	19	22	336	336	NUM
admet-2042	19	23	the	the	DET
admet-2042	19	24	phenomenon	phenomenon	NOUN
admet-2042	19	25	of	of	ADP
admet-2042	19	26	supersaturation	supersaturation	NOUN
admet-2042	19	27	is	be	AUX
admet-2042	19	28	triggered	trigger	VERB
admet-2042	19	29	by	by	ADP
admet-2042	19	30	the	the	DET
admet-2042	19	31	decrease	decrease	NOUN
admet-2042	19	32	in	in	ADP
admet-2042	19	33	solubility	solubility	NOUN
admet-2042	19	34	resulting	result	VERB
admet-2042	19	35	from	from	ADP
admet-2042	19	36	the	the	DET
admet-2042	19	37	ph	ph	ADJ
admet-2042	19	38	increase	increase	NOUN
admet-2042	19	39	as	as	SCONJ
admet-2042	19	40	the	the	DET
admet-2042	19	41	substances	substance	NOUN
admet-2042	19	42	proceed	proceed	VERB
admet-2042	19	43	from	from	ADP
admet-2042	19	44	the	the	DET
admet-2042	19	45	stomach	stomach	NOUN
admet-2042	19	46	to	to	ADP
admet-2042	19	47	the	the	DET
admet-2042	19	48	small	small	ADJ
admet-2042	19	49	intestine	intestine	NOUN
admet-2042	19	50	.	.	PUNCT
admet-2042	20	1	supersaturation	supersaturation	NOUN
admet-2042	20	2	is	be	AUX
admet-2042	20	3	a	a	DET
admet-2042	20	4	state	state	NOUN
admet-2042	20	5	characterized	characterize	VERB
admet-2042	20	6	by	by	ADP
admet-2042	20	7	the	the	DET
admet-2042	20	8	concentration	concentration	NOUN
admet-2042	20	9	of	of	ADP
admet-2042	20	10	the	the	DET
admet-2042	20	11	drug	drug	NOUN
admet-2042	20	12	exceeding	exceed	VERB
admet-2042	20	13	the	the	DET
admet-2042	20	14	solubility	solubility	NOUN
admet-2042	20	15	equilibrium	equilibrium	NOUN
admet-2042	20	16	.	.	PUNCT
admet-2042	21	1	in	in	ADP
admet-2042	21	2	the	the	DET
admet-2042	21	3	present	present	ADJ
admet-2042	21	4	circumstances	circumstance	NOUN
admet-2042	21	5	,	,	PUNCT
admet-2042	21	6	there	there	PRON
admet-2042	21	7	is	be	VERB
admet-2042	21	8	a	a	DET
admet-2042	21	9	considerable	considerable	ADJ
admet-2042	21	10	augmentation	augmentation	NOUN
admet-2042	21	11	in	in	ADP
admet-2042	21	12	the	the	DET
admet-2042	21	13	drug	drug	NOUN
admet-2042	21	14	's	's	PART
admet-2042	21	15	solubility	solubility	NOUN
admet-2042	21	16	;	;	PUNCT
admet-2042	21	17	nonetheless	nonetheless	ADV
admet-2042	21	18	,	,	PUNCT
admet-2042	21	19	it	it	PRON
admet-2042	21	20	is	be	AUX
admet-2042	21	21	imperative	imperative	ADJ
admet-2042	21	22	to	to	PART
admet-2042	21	23	understand	understand	VERB
admet-2042	21	24	that	that	DET
admet-2042	21	25	supersaturation	supersaturation	NOUN
admet-2042	21	26	exhibits	exhibit	VERB
admet-2042	21	27	inherent	inherent	ADJ
admet-2042	21	28	thermodynamic	thermodynamic	ADJ
admet-2042	21	29	instability	instability	NOUN
admet-2042	21	30	.	.	PUNCT
admet-2042	22	1	hence	hence	ADV
admet-2042	22	2	,	,	PUNCT
admet-2042	22	3	when	when	SCONJ
admet-2042	22	4	reaching	reach	VERB
admet-2042	22	5	its	its	PRON
admet-2042	22	6	critical	critical	ADJ
admet-2042	22	7	concentration	concentration	NOUN
admet-2042	22	8	,	,	PUNCT
admet-2042	22	9	the	the	DET
admet-2042	22	10	drug	drug	NOUN
admet-2042	22	11	undergoes	undergo	VERB
admet-2042	22	12	nucleation	nucleation	NOUN
admet-2042	22	13	,	,	PUNCT
admet-2042	22	14	subsequently	subsequently	ADV
admet-2042	22	15	leading	lead	VERB
admet-2042	22	16	to	to	ADP
admet-2042	22	17	precipitation	precipitation	NOUN
admet-2042	22	18	.	.	PUNCT
admet-2042	23	1	the	the	DET
admet-2042	23	2	occurrence	occurrence	NOUN
admet-2042	23	3	of	of	ADP
admet-2042	23	4	precipitation	precipitation	NOUN
admet-2042	23	5	reduces	reduce	VERB
admet-2042	23	6	concentration	concentration	NOUN
admet-2042	23	7	due	due	ADP
admet-2042	23	8	to	to	ADP
admet-2042	23	9	the	the	DET
admet-2042	23	10	expansion	expansion	NOUN
admet-2042	23	11	of	of	ADP
admet-2042	23	12	particles	particle	NOUN
admet-2042	23	13	originating	originate	VERB
admet-2042	23	14	from	from	ADP
admet-2042	23	15	nuclei	nucleus	NOUN
admet-2042	23	16	[	[	X
admet-2042	23	17	3,4	3,4	NUM
admet-2042	23	18	]	]	PUNCT
admet-2042	23	19	.	.	PUNCT
admet-2042	24	1	the	the	DET
admet-2042	24	2	presence	presence	NOUN
admet-2042	24	3	of	of	ADP
admet-2042	24	4	precipitation	precipitation	NOUN
admet-2042	24	5	might	might	AUX
admet-2042	24	6	influence	influence	VERB
admet-2042	24	7	the	the	DET
admet-2042	24	8	rate	rate	NOUN
admet-2042	24	9	and	and	CCONJ
admet-2042	24	10	amount	amount	NOUN
admet-2042	24	11	of	of	ADP
admet-2042	24	12	drug	drug	NOUN
admet-2042	24	13	absorption	absorption	NOUN
admet-2042	24	14	within	within	ADP
admet-2042	24	15	the	the	DET
admet-2042	24	16	gastrointestinal	gastrointestinal	ADJ
admet-2042	24	17	tract	tract	NOUN
admet-2042	24	18	,	,	PUNCT
admet-2042	24	19	thereby	thereby	ADV
admet-2042	24	20	impacting	impact	VERB
admet-2042	24	21	the	the	DET
admet-2042	24	22	bioavailability	bioavailability	NOUN
admet-2042	24	23	of	of	ADP
admet-2042	24	24	the	the	DET
admet-2042	24	25	therapy	therapy	NOUN
admet-2042	24	26	[	[	X
admet-2042	24	27	5	5	NUM
admet-2042	24	28	]	]	PUNCT
admet-2042	24	29	.	.	PUNCT
admet-2042	25	1	the	the	DET
admet-2042	25	2	combination	combination	NOUN
admet-2042	25	3	of	of	ADP
admet-2042	25	4	alginate	alginate	NOUN
admet-2042	25	5	:	:	PUNCT
admet-2042	25	6	gum	gum	NOUN
admet-2042	25	7	acacia	acacia	NOUN
admet-2042	25	8	with	with	ADP
admet-2042	25	9	mass	mass	ADJ
admet-2042	25	10	ratio	ratio	NOUN
admet-2042	25	11	75:25	75:25	NUM
admet-2042	25	12	in	in	ADP
admet-2042	25	13	previous	previous	ADJ
admet-2042	25	14	studies	study	NOUN
admet-2042	25	15	showed	show	VERB
admet-2042	25	16	good	good	ADJ
admet-2042	25	17	results	result	NOUN
admet-2042	25	18	in	in	ADP
admet-2042	25	19	inhibiting	inhibit	VERB
admet-2042	25	20	ketoconazole	ketoconazole	NOUN
admet-2042	25	21	precipitation	precipitation	NOUN
admet-2042	25	22	,	,	PUNCT
admet-2042	25	23	which	which	PRON
admet-2042	25	24	can	can	AUX
admet-2042	25	25	maintain	maintain	VERB
admet-2042	25	26	the	the	DET
admet-2042	25	27	supersaturation	supersaturation	NOUN
admet-2042	25	28	phase	phase	NOUN
admet-2042	25	29	for	for	ADP
admet-2042	25	30	60	60	NUM
admet-2042	25	31	minutes	minute	NOUN
admet-2042	25	32	compared	compare	VERB
admet-2042	25	33	to	to	ADP
admet-2042	25	34	pure	pure	ADJ
admet-2042	25	35	ketoconazole	ketoconazole	NOUN
admet-2042	25	36	,	,	PUNCT
admet-2042	25	37	which	which	PRON
admet-2042	25	38	is	be	AUX
admet-2042	25	39	only	only	ADV
admet-2042	25	40	20	20	NUM
admet-2042	25	41	minutes	minute	NOUN
admet-2042	25	42	.	.	PUNCT
admet-2042	26	1	this	this	DET
admet-2042	26	2	interaction	interaction	NOUN
admet-2042	26	3	occurs	occur	VERB
admet-2042	26	4	through	through	ADP
admet-2042	26	5	hydrogen	hydrogen	NOUN
admet-2042	26	6	bonding	bonding	NOUN
admet-2042	26	7	between	between	ADP
admet-2042	26	8	the	the	DET
admet-2042	26	9	negative	negative	ADJ
admet-2042	26	10	group	group	NOUN
admet-2042	26	11	of	of	ADP
admet-2042	26	12	the	the	DET
admet-2042	26	13	polymer	polymer	NOUN
admet-2042	26	14	as	as	ADP
admet-2042	26	15	a	a	DET
admet-2042	26	16	hydrogen	hydrogen	NOUN
admet-2042	26	17	group	group	NOUN
admet-2042	26	18	donor	donor	NOUN
admet-2042	26	19	and	and	CCONJ
admet-2042	26	20	the	the	DET
admet-2042	26	21	hydrogen	hydrogen	NOUN
admet-2042	26	22	receptor	receptor	NOUN
admet-2042	26	23	group	group	NOUN
admet-2042	26	24	on	on	ADP
admet-2042	26	25	ketoconazole	ketoconazole	PROPN
admet-2042	26	26	.	.	PUNCT
admet-2042	27	1	hydrogen	hydrogen	NOUN
admet-2042	27	2	bonding	bonding	NOUN
admet-2042	27	3	between	between	ADP
admet-2042	27	4	drug	drug	NOUN
admet-2042	27	5	molecules	molecule	NOUN
admet-2042	27	6	and	and	CCONJ
admet-2042	27	7	polymers	polymer	NOUN
admet-2042	27	8	can	can	AUX
admet-2042	27	9	increase	increase	VERB
admet-2042	27	10	the	the	DET
admet-2042	27	11	activation	activation	NOUN
admet-2042	27	12	energy	energy	NOUN
admet-2042	27	13	of	of	ADP
admet-2042	27	14	nucleation	nucleation	NOUN
admet-2042	27	15	,	,	PUNCT
admet-2042	27	16	thus	thus	ADV
admet-2042	27	17	inhibiting	inhibit	VERB
admet-2042	27	18	nucleation	nucleation	NOUN
admet-2042	27	19	and	and	CCONJ
admet-2042	27	20	crystal	crystal	NOUN
admet-2042	27	21	growth	growth	NOUN
admet-2042	27	22	[	[	X
admet-2042	27	23	6	6	NUM
admet-2042	27	24	]	]	PUNCT
admet-2042	27	25	.	.	PUNCT
admet-2042	28	1	alginate	alginate	NOUN
admet-2042	28	2	and	and	CCONJ
admet-2042	28	3	gum	gum	NOUN
admet-2042	28	4	acacia	acacia	NOUN
admet-2042	28	5	can	can	AUX
admet-2042	28	6	produce	produce	VERB
admet-2042	28	7	a	a	DET
admet-2042	28	8	hydrogel	hydrogel	NOUN
admet-2042	28	9	through	through	ADP
admet-2042	28	10	cross	cross	NOUN
admet-2042	28	11	-	-	ADJ
admet-2042	28	12	linking	link	VERB
admet-2042	28	13	with	with	ADP
admet-2042	28	14	ca2	ca2	PROPN
admet-2042	28	15	+	+	PROPN
admet-2042	28	16	using	use	VERB
admet-2042	28	17	ionotropic	ionotropic	ADJ
admet-2042	28	18	gelation	gelation	NOUN
admet-2042	28	19	techniques	technique	NOUN
admet-2042	28	20	[	[	X
admet-2042	28	21	7	7	NUM
admet-2042	28	22	]	]	PUNCT
admet-2042	28	23	.	.	PUNCT
admet-2042	29	1	the	the	DET
admet-2042	29	2	combination	combination	NOUN
admet-2042	29	3	produces	produce	VERB
admet-2042	29	4	mechanical	mechanical	ADJ
admet-2042	29	5	properties	property	NOUN
admet-2042	29	6	of	of	ADP
admet-2042	29	7	the	the	DET
admet-2042	29	8	polymer	polymer	NOUN
admet-2042	29	9	network	network	NOUN
admet-2042	29	10	to	to	PART
admet-2042	29	11	form	form	VERB
admet-2042	29	12	a	a	DET
admet-2042	29	13	stronger	strong	ADJ
admet-2042	29	14	hydrogel	hydrogel	NOUN
admet-2042	29	15	.	.	PUNCT
admet-2042	30	1	gum	gum	NOUN
admet-2042	30	2	acacia	acacia	NOUN
admet-2042	30	3	is	be	AUX
admet-2042	30	4	a	a	DET
admet-2042	30	5	good	good	ADJ
admet-2042	30	6	material	material	NOUN
admet-2042	30	7	to	to	PART
admet-2042	30	8	improve	improve	VERB
admet-2042	30	9	the	the	DET
admet-2042	30	10	physico	physico	NOUN
admet-2042	30	11	-	-	PUNCT
admet-2042	30	12	chemical	chemical	NOUN
admet-2042	30	13	properties	property	NOUN
admet-2042	30	14	of	of	ADP
admet-2042	30	15	alginate	alginate	NOUN
admet-2042	30	16	hydrogel	hydrogel	NOUN
admet-2042	30	17	beads	bead	NOUN
admet-2042	30	18	.	.	PUNCT
admet-2042	31	1	the	the	DET
admet-2042	31	2	addition	addition	NOUN
admet-2042	31	3	of	of	ADP
admet-2042	31	4	gum	gum	NOUN
admet-2042	31	5	acacia	acacia	NOUN
admet-2042	31	6	to	to	ADP
admet-2042	31	7	the	the	DET
admet-2042	31	8	alginate	alginate	NOUN
admet-2042	31	9	solution	solution	NOUN
admet-2042	31	10	can	can	AUX
admet-2042	31	11	reduce	reduce	VERB
admet-2042	31	12	the	the	DET
admet-2042	31	13	side	side	NOUN
admet-2042	31	14	-	-	PUNCT
admet-2042	31	15	by	by	ADP
admet-2042	31	16	-	-	PUNCT
admet-2042	31	17	side	side	NOUN
admet-2042	31	18	aggregation	aggregation	NOUN
admet-2042	31	19	of	of	ADP
admet-2042	31	20	the	the	DET
admet-2042	31	21	alginate	alginate	NOUN
admet-2042	31	22	egg	egg	NOUN
admet-2042	31	23	-	-	PUNCT
admet-2042	31	24	box	box	NOUN
admet-2042	31	25	structure	structure	NOUN
admet-2042	31	26	due	due	ADP
admet-2042	31	27	to	to	ADP
admet-2042	31	28	the	the	DET
admet-2042	31	29	presence	presence	NOUN
admet-2042	31	30	of	of	ADP
admet-2042	31	31	ca2	ca2	PROPN
admet-2042	31	32	+	+	PROPN
admet-2042	32	1	[	[	X
admet-2042	32	2	8	8	NUM
admet-2042	32	3	]	]	PUNCT
admet-2042	32	4	.	.	PUNCT
admet-2042	33	1	the	the	DET
admet-2042	33	2	results	result	NOUN
admet-2042	33	3	of	of	ADP
admet-2042	33	4	synergistic	synergistic	ADJ
admet-2042	33	5	testing	testing	NOUN
admet-2042	33	6	of	of	ADP
admet-2042	33	7	the	the	DET
admet-2042	33	8	ag75	ag75	PROPN
admet-2042	33	9	combination	combination	NOUN
admet-2042	33	10	that	that	PRON
admet-2042	33	11	has	have	AUX
admet-2042	33	12	been	be	AUX
admet-2042	33	13	carried	carry	VERB
admet-2042	33	14	out	out	ADP
admet-2042	33	15	previously	previously	ADV
admet-2042	33	16	show	show	VERB
admet-2042	33	17	a	a	DET
admet-2042	33	18	synergistic	synergistic	ADJ
admet-2042	33	19	effect	effect	NOUN
admet-2042	33	20	between	between	ADP
admet-2042	33	21	alginate	alginate	NOUN
admet-2042	33	22	and	and	CCONJ
admet-2042	33	23	gum	gum	NOUN
admet-2042	33	24	acacia	acacia	NOUN
admet-2042	33	25	with	with	ADP
admet-2042	33	26	a	a	DET
admet-2042	33	27	mass	mass	ADJ
admet-2042	33	28	ratio	ratio	NOUN
admet-2042	33	29	of	of	ADP
admet-2042	33	30	75:25	75:25	NUM
admet-2042	33	31	[	[	X
admet-2042	33	32	9	9	NUM
admet-2042	33	33	]	]	PUNCT
admet-2042	33	34	.	.	PUNCT
admet-2042	34	1	however	however	ADV
admet-2042	34	2	,	,	PUNCT
admet-2042	34	3	the	the	DET
admet-2042	34	4	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	34	5	study	study	NOUN
admet-2042	34	6	of	of	ADP
admet-2042	34	7	the	the	DET
admet-2042	34	8	ketoconazole	ketoconazole	NOUN
admet-2042	34	9	beads	bead	NOUN
admet-2042	34	10	loaded	load	VERB
admet-2042	34	11	to	to	PART
admet-2042	34	12	alginate	alginate	VERB
admet-2042	34	13	and	and	CCONJ
admet-2042	34	14	gum	gum	NOUN
admet-2042	34	15	acacia	acacia	NOUN
admet-2042	34	16	needs	need	VERB
admet-2042	34	17	further	further	ADJ
admet-2042	34	18	investigation	investigation	NOUN
admet-2042	34	19	.	.	PUNCT
admet-2042	35	1	therefore	therefore	ADV
admet-2042	35	2	,	,	PUNCT
admet-2042	35	3	the	the	DET
admet-2042	35	4	aim	aim	NOUN
admet-2042	35	5	of	of	ADP
admet-2042	35	6	this	this	DET
admet-2042	35	7	research	research	NOUN
admet-2042	35	8	was	be	AUX
admet-2042	35	9	to	to	PART
admet-2042	35	10	evaluate	evaluate	VERB
admet-2042	35	11	the	the	DET
admet-2042	35	12	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	35	13	parameter	parameter	NOUN
admet-2042	35	14	of	of	ADP
admet-2042	35	15	ketoconazole	ketoconazole	NOUN
admet-2042	35	16	-	-	PUNCT
admet-2042	35	17	loaded	load	VERB
admet-2042	35	18	alginat	alginat	NOUN
admet-2042	35	19	:	:	PUNCT
admet-2042	35	20	gum	gum	NOUN
admet-2042	35	21	acacia	acacia	NOUN
admet-2042	35	22	with	with	ADP
admet-2042	35	23	a	a	DET
admet-2042	35	24	mass	mass	ADJ
admet-2042	35	25	ratio	ratio	NOUN
admet-2042	35	26	of	of	ADP
admet-2042	35	27	75:25	75:25	NUM
admet-2042	35	28	produced	produce	VERB
admet-2042	35	29	and	and	CCONJ
admet-2042	35	30	characterized	characterize	VERB
admet-2042	35	31	in	in	ADP
admet-2042	35	32	the	the	DET
admet-2042	35	33	previous	previous	ADJ
admet-2042	35	34	study	study	NOUN
admet-2042	35	35	[	[	X
admet-2042	35	36	10	10	NUM
admet-2042	35	37	]	]	PUNCT
admet-2042	35	38	.	.	PUNCT
admet-2042	36	1	the	the	DET
admet-2042	36	2	characterization	characterization	NOUN
admet-2042	36	3	results	result	NOUN
admet-2042	36	4	show	show	VERB
admet-2042	36	5	that	that	SCONJ
admet-2042	36	6	ketoconazole	ketoconazole	NOUN
admet-2042	36	7	was	be	AUX
admet-2042	36	8	successfully	successfully	ADV
admet-2042	36	9	loaded	load	VERB
admet-2042	36	10	in	in	ADP
admet-2042	36	11	the	the	DET
admet-2042	36	12	matrix	matrix	NOUN
admet-2042	36	13	polymer	polymer	NOUN
admet-2042	36	14	,	,	PUNCT
admet-2042	36	15	the	the	DET
admet-2042	36	16	testing	testing	NOUN
admet-2042	36	17	including	include	VERB
admet-2042	36	18	differential	differential	NOUN
admet-2042	36	19	scanning	scanning	NOUN
admet-2042	36	20	calorimetry	calorimetry	NOUN
admet-2042	36	21	(	(	PUNCT
admet-2042	36	22	dsc	dsc	NOUN
admet-2042	36	23	)	)	PUNCT
admet-2042	36	24	,	,	PUNCT
admet-2042	36	25	scanning	scan	VERB
admet-2042	36	26	electron	electron	NOUN
admet-2042	36	27	microscopy	microscopy	NOUN
admet-2042	36	28	(	(	PUNCT
admet-2042	36	29	sem	sem	NOUN
admet-2042	36	30	)	)	PUNCT
admet-2042	36	31	,	,	PUNCT
admet-2042	36	32	fourier	fourier	NOUN
admet-2042	36	33	transform	transform	VERB
admet-2042	36	34	infrared	infrared	ADJ
admet-2042	36	35	(	(	PUNCT
admet-2042	36	36	ft	ft	NOUN
admet-2042	36	37	-	-	PUNCT
admet-2042	36	38	ir	ir	NOUN
admet-2042	36	39	)	)	PUNCT
admet-2042	36	40	,	,	PUNCT
admet-2042	36	41	x	x	X
admet-2042	36	42	-	-	NOUN
admet-2042	36	43	ray	ray	NOUN
admet-2042	36	44	diffraction	diffraction	NOUN
admet-2042	36	45	(	(	PUNCT
admet-2042	36	46	xrd	xrd	NOUN
admet-2042	36	47	)	)	PUNCT
admet-2042	36	48	,	,	PUNCT
admet-2042	36	49	swelling	swell	VERB
admet-2042	36	50	study	study	NOUN
admet-2042	36	51	,	,	PUNCT
admet-2042	36	52	in	in	ADP
admet-2042	36	53	vitro	vitro	X
admet-2042	36	54	drug	drug	NOUN
admet-2042	36	55	release	release	NOUN
admet-2042	36	56	study	study	NOUN
admet-2042	36	57	,	,	PUNCT
admet-2042	36	58	and	and	CCONJ
admet-2042	36	59	solubility	solubility	NOUN
admet-2042	36	60	determination	determination	NOUN
admet-2042	36	61	.	.	PUNCT
admet-2042	37	1	experimental	experimental	ADJ
admet-2042	37	2	materials	material	NOUN
admet-2042	37	3	ketoconazole	ketoconazole	NOUN
admet-2042	37	4	and	and	CCONJ
admet-2042	37	5	itraconazole	itraconazole	PROPN
admet-2042	37	6	standard	standard	PROPN
admet-2042	37	7	were	be	AUX
admet-2042	37	8	bought	buy	VERB
admet-2042	37	9	from	from	ADP
admet-2042	37	10	bpom	bpom	NOUN
admet-2042	37	11	,	,	PUNCT
admet-2042	37	12	indonesia	indonesia	PROPN
admet-2042	37	13	.	.	PUNCT
admet-2042	38	1	ketoconazole	ketoconazole	PROPN
admet-2042	38	2	's	's	PART
admet-2042	38	3	active	active	ADJ
admet-2042	38	4	component	component	NOUN
admet-2042	38	5	was	be	AUX
admet-2042	38	6	obtained	obtain	VERB
admet-2042	38	7	from	from	ADP
admet-2042	38	8	kimia	kimia	NOUN
admet-2042	38	9	farma	farma	PROPN
admet-2042	38	10	corps	corps	PROPN
admet-2042	38	11	,	,	PUNCT
admet-2042	38	12	indonesia	indonesia	PROPN
admet-2042	38	13	.	.	PUNCT
admet-2042	39	1	edta	edta	PROPN
admet-2042	39	2	k3	k3	VERB
admet-2042	39	3	2	2	NUM
admet-2042	39	4	ml	ml	NOUN
admet-2042	39	5	(	(	PUNCT
admet-2042	39	6	golden	golden	ADJ
admet-2042	39	7	vac	vac	NOUN
admet-2042	39	8	,	,	PUNCT
admet-2042	39	9	china	china	PROPN
admet-2042	39	10	)	)	PUNCT
admet-2042	39	11	.	.	PUNCT
admet-2042	40	1	the	the	DET
admet-2042	40	2	sterile	sterile	ADJ
admet-2042	40	3	water	water	NOUN
admet-2042	40	4	for	for	ADP
admet-2042	40	5	injection	injection	NOUN
admet-2042	40	6	was	be	AUX
admet-2042	40	7	manufactured	manufacture	VERB
admet-2042	40	8	by	by	ADP
admet-2042	40	9	ikapharmindo	ikapharmindo	PROPN
admet-2042	40	10	,	,	PUNCT
admet-2042	40	11	indonesia	indonesia	PROPN
admet-2042	40	12	.	.	PROPN
admet-2042	41	1	deionized	deionize	VERB
admet-2042	41	2	water	water	NOUN
admet-2042	41	3	was	be	AUX
admet-2042	41	4	supplied	supply	VERB
admet-2042	41	5	from	from	ADP
admet-2042	41	6	cv	cv	PROPN
admet-2042	41	7	.	.	PROPN
admet-2042	41	8	alfa	alfa	PROPN
admet-2042	41	9	kimia	kimia	PROPN
admet-2042	41	10	.	.	PUNCT
admet-2042	42	1	acetonitrile	acetonitrile	ADJ
admet-2042	42	2	gradient	gradient	PROPN
admet-2042	42	3	grades	grade	NOUN
admet-2042	42	4	for	for	ADP
admet-2042	42	5	hplc	hplc	NOUN
admet-2042	42	6	(	(	PUNCT
admet-2042	42	7	merck	merck	PROPN
admet-2042	42	8	,	,	PUNCT
admet-2042	42	9	germany	germany	PROPN
admet-2042	42	10	)	)	PUNCT
admet-2042	42	11	,	,	PUNCT
admet-2042	42	12	nah2po2	nah2po2	PROPN
admet-2042	42	13	(	(	PUNCT
admet-2042	42	14	merck	merck	PROPN
admet-2042	42	15	,	,	PUNCT
admet-2042	42	16	germany	germany	PROPN
admet-2042	42	17	)	)	PUNCT
admet-2042	42	18	,	,	PUNCT
admet-2042	42	19	and	and	CCONJ
admet-2042	42	20	naoh	naoh	NOUN
admet-2042	42	21	(	(	PUNCT
admet-2042	42	22	merck	merck	PROPN
admet-2042	42	23	,	,	PUNCT
admet-2042	42	24	germany	germany	PROPN
admet-2042	42	25	)	)	PUNCT
admet-2042	42	26	.	.	PUNCT
admet-2042	43	1	animals	animal	NOUN
admet-2042	43	2	three	three	NUM
admet-2042	43	3	male	male	ADJ
admet-2042	43	4	new	new	ADJ
admet-2042	43	5	zealand	zealand	PROPN
admet-2042	43	6	white	white	PROPN
admet-2042	43	7	rabbits	rabbit	NOUN
admet-2042	43	8	,	,	PUNCT
admet-2042	43	9	aged	age	VERB
admet-2042	43	10	between	between	ADP
admet-2042	43	11	three	three	NUM
admet-2042	43	12	to	to	PART
admet-2042	43	13	four	four	NUM
admet-2042	43	14	months	month	NOUN
admet-2042	43	15	,	,	PUNCT
admet-2042	43	16	with	with	ADP
admet-2042	43	17	an	an	DET
admet-2042	43	18	average	average	ADJ
admet-2042	43	19	weight	weight	NOUN
admet-2042	43	20	ranging	range	VERB
admet-2042	43	21	from	from	ADP
admet-2042	43	22	2.5	2.5	NUM
admet-2042	43	23	to	to	PART
admet-2042	43	24	3	3	NUM
admet-2042	43	25	kilograms	kilogram	NOUN
admet-2042	43	26	,	,	PUNCT
admet-2042	43	27	were	be	AUX
admet-2042	43	28	bought	buy	VERB
admet-2042	43	29	from	from	ADP
admet-2042	43	30	terminal	terminal	ADJ
admet-2042	43	31	kelinci	kelinci	PROPN
admet-2042	43	32	,	,	PUNCT
admet-2042	43	33	a	a	DET
admet-2042	43	34	reputable	reputable	ADJ
admet-2042	43	35	rabbit	rabbit	NOUN
admet-2042	43	36	breeder	breeder	NOUN
admet-2042	43	37	in	in	ADP
admet-2042	43	38	yogyakarta	yogyakarta	PROPN
admet-2042	43	39	,	,	PUNCT
admet-2042	43	40	indonesia	indonesia	PROPN
admet-2042	43	41	.	.	PUNCT
admet-2042	44	1	three	three	NUM
admet-2042	44	2	rabbits	rabbit	NOUN
admet-2042	44	3	were	be	AUX
admet-2042	44	4	housed	house	VERB
admet-2042	44	5	in	in	ADP
admet-2042	44	6	a	a	DET
admet-2042	44	7	controlled	control	VERB
admet-2042	44	8	environment	environment	NOUN
admet-2042	44	9	within	within	ADP
admet-2042	44	10	the	the	DET
admet-2042	44	11	laboratory	laboratory	NOUN
admet-2042	44	12	animal	animal	NOUN
admet-2042	44	13	building	building	NOUN
admet-2042	44	14	,	,	PUNCT
admet-2042	44	15	specifically	specifically	ADV
admet-2042	44	16	at	at	ADP
admet-2042	44	17	the	the	DET
admet-2042	44	18	pharmacology	pharmacology	NOUN
admet-2042	44	19	department	department	NOUN
admet-2042	44	20	of	of	ADP
admet-2042	44	21	the	the	DET
admet-2042	44	22	faculty	faculty	NOUN
admet-2042	44	23	of	of	ADP
admet-2042	44	24	pharmacy	pharmacy	NOUN
admet-2042	44	25	in	in	ADP
admet-2042	44	26	indonesia	indonesia	PROPN
admet-2042	44	27	.	.	PUNCT
admet-2042	45	1	the	the	DET
admet-2042	45	2	rabbits	rabbit	NOUN
admet-2042	45	3	were	be	AUX
admet-2042	45	4	subjected	subject	VERB
admet-2042	45	5	to	to	ADP
admet-2042	45	6	a	a	DET
admet-2042	45	7	12	12	NUM
admet-2042	45	8	-	-	PUNCT
admet-2042	45	9	hour	hour	NOUN
admet-2042	45	10	light	light	NOUN
admet-2042	45	11	and	and	CCONJ
admet-2042	45	12	dark	dark	ADJ
admet-2042	45	13	cycle	cycle	NOUN
admet-2042	45	14	.	.	PUNCT
admet-2042	46	1	their	their	PRON
admet-2042	46	2	diet	diet	NOUN
admet-2042	46	3	consisted	consist	VERB
admet-2042	46	4	of	of	ADP
admet-2042	46	5	vital	vital	ADJ
admet-2042	46	6	rabbit	rabbit	NOUN
admet-2042	46	7	chow	chow	NOUN
admet-2042	46	8	,	,	PUNCT
admet-2042	46	9	manufactured	manufacture	VERB
admet-2042	46	10	by	by	ADP
admet-2042	46	11	citrafeed	citrafeed	NOUN
admet-2042	46	12	in	in	ADP
admet-2042	46	13	indonesia	indonesia	PROPN
admet-2042	46	14	,	,	PUNCT
admet-2042	46	15	and	and	CCONJ
admet-2042	46	16	they	they	PRON
admet-2042	46	17	had	have	VERB
admet-2042	46	18	unrestricted	unrestricted	ADJ
admet-2042	46	19	access	access	NOUN
admet-2042	46	20	to	to	ADP
admet-2042	46	21	water	water	NOUN
admet-2042	46	22	.	.	PUNCT
admet-2042	47	1	admet	admet	PROPN
admet-2042	47	2	&	&	CCONJ
admet-2042	47	3	dmpk	dmpk	PROPN
admet-2042	47	4	12(2	12(2	NUM
admet-2042	47	5	)	)	PUNCT
admet-2042	47	6	(	(	PUNCT
admet-2042	47	7	2024	2024	NUM
admet-2042	47	8	)	)	PUNCT
admet-2042	47	9	335	335	NUM
admet-2042	47	10	-	-	SYM
admet-2042	47	11	341	341	NUM
admet-2042	47	12	newly	newly	ADV
admet-2042	47	13	formulated	formulate	VERB
admet-2042	47	14	beads	bead	NOUN
admet-2042	47	15	alginate	alginate	NOUN
admet-2042	47	16	/	/	SYM
admet-2042	47	17	gum	gum	NOUN
admet-2042	47	18	acacia	acacia	NOUN
admet-2042	47	19	loaded	load	VERB
admet-2042	47	20	ketoconazole	ketoconazole	NOUN
admet-2042	47	21	doi	doi	PROPN
admet-2042	47	22	:	:	PUNCT
admet-2042	47	23	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	NOUN
admet-2042	47	24	337	337	NUM
admet-2042	47	25	blood	blood	NOUN
admet-2042	47	26	sampling	sampling	NOUN
admet-2042	47	27	and	and	CCONJ
admet-2042	47	28	sample	sample	NOUN
admet-2042	47	29	preparation	preparation	NOUN
admet-2042	47	30	the	the	DET
admet-2042	47	31	rabbits	rabbit	NOUN
admet-2042	47	32	underwent	undergo	VERB
admet-2042	47	33	an	an	DET
admet-2042	47	34	overnight	overnight	ADJ
admet-2042	47	35	fasting	fasting	NOUN
admet-2042	47	36	period	period	NOUN
admet-2042	47	37	before	before	ADP
admet-2042	47	38	the	the	DET
admet-2042	47	39	commencement	commencement	NOUN
admet-2042	47	40	of	of	ADP
admet-2042	47	41	the	the	DET
admet-2042	47	42	experiment	experiment	NOUN
admet-2042	47	43	.	.	PUNCT
admet-2042	48	1	a	a	DET
admet-2042	48	2	dosage	dosage	NOUN
admet-2042	48	3	of	of	ADP
admet-2042	48	4	14	14	NUM
admet-2042	48	5	mg	mg	PROPN
admet-2042	48	6	kg-1	kg-1	NOUN
admet-2042	48	7	of	of	ADP
admet-2042	48	8	ktz	ktz	PROPN
admet-2042	48	9	was	be	AUX
admet-2042	48	10	supplied	supply	VERB
admet-2042	48	11	to	to	ADP
admet-2042	48	12	the	the	DET
admet-2042	48	13	rabbits	rabbit	NOUN
admet-2042	48	14	,	,	PUNCT
admet-2042	48	15	similar	similar	ADJ
admet-2042	48	16	to	to	ADP
admet-2042	48	17	the	the	DET
admet-2042	48	18	human	human	ADJ
admet-2042	48	19	dosage	dosage	NOUN
admet-2042	48	20	of	of	ADP
admet-2042	48	21	400	400	NUM
admet-2042	48	22	mg	mg	NOUN
admet-2042	48	23	of	of	ADP
admet-2042	48	24	ktz	ktz	NOUN
admet-2042	48	25	.	.	PUNCT
admet-2042	49	1	the	the	DET
admet-2042	49	2	drugs	drug	NOUN
admet-2042	49	3	were	be	AUX
admet-2042	49	4	administered	administer	VERB
admet-2042	49	5	orally	orally	ADV
admet-2042	49	6	to	to	ADP
admet-2042	49	7	the	the	DET
admet-2042	49	8	rabbit	rabbit	NOUN
admet-2042	49	9	via	via	ADP
admet-2042	49	10	a	a	DET
admet-2042	49	11	tube	tube	NOUN
admet-2042	49	12	.	.	PUNCT
admet-2042	50	1	approximately	approximately	ADV
admet-2042	50	2	2	2	NUM
admet-2042	50	3	ml	ml	NOUN
admet-2042	50	4	blood	blood	NOUN
admet-2042	50	5	samples	sample	NOUN
admet-2042	50	6	were	be	AUX
admet-2042	50	7	obtained	obtain	VERB
admet-2042	50	8	as	as	ADP
admet-2042	50	9	aliquots	aliquot	NOUN
admet-2042	50	10	from	from	ADP
admet-2042	50	11	the	the	DET
admet-2042	50	12	ear	ear	NOUN
admet-2042	50	13	marginal	marginal	ADJ
admet-2042	50	14	vein	vein	NOUN
admet-2042	50	15	at	at	ADP
admet-2042	50	16	various	various	ADJ
admet-2042	50	17	time	time	NOUN
admet-2042	50	18	points	point	NOUN
admet-2042	50	19	:	:	PUNCT
admet-2042	50	20	0	0	NUM
admet-2042	51	1	(	(	PUNCT
admet-2042	51	2	before	before	ADP
admet-2042	51	3	administration	administration	NOUN
admet-2042	51	4	)	)	PUNCT
admet-2042	51	5	,	,	PUNCT
admet-2042	51	6	15	15	NUM
admet-2042	51	7	,	,	PUNCT
admet-2042	51	8	30	30	NUM
admet-2042	51	9	,	,	PUNCT
admet-2042	51	10	45	45	NUM
admet-2042	51	11	,	,	PUNCT
admet-2042	51	12	60	60	NUM
admet-2042	51	13	,	,	PUNCT
admet-2042	51	14	90	90	NUM
admet-2042	51	15	,	,	PUNCT
admet-2042	51	16	120	120	NUM
admet-2042	51	17	,	,	PUNCT
admet-2042	51	18	150	150	NUM
admet-2042	51	19	,	,	PUNCT
admet-2042	51	20	180	180	NUM
admet-2042	51	21	,	,	PUNCT
admet-2042	51	22	240	240	NUM
admet-2042	51	23	,	,	PUNCT
admet-2042	51	24	300	300	NUM
admet-2042	51	25	,	,	PUNCT
admet-2042	51	26	360	360	NUM
admet-2042	51	27	,	,	PUNCT
admet-2042	51	28	and	and	CCONJ
admet-2042	51	29	420	420	NUM
admet-2042	51	30	minutes	minute	NOUN
admet-2042	51	31	after	after	ADP
admet-2042	51	32	oral	oral	ADJ
admet-2042	51	33	dosage	dosage	NOUN
admet-2042	51	34	.	.	PUNCT
admet-2042	52	1	the	the	DET
admet-2042	52	2	sample	sample	NOUN
admet-2042	52	3	was	be	AUX
admet-2042	52	4	obtained	obtain	VERB
admet-2042	52	5	and	and	CCONJ
admet-2042	52	6	placed	place	VERB
admet-2042	52	7	in	in	ADP
admet-2042	52	8	a	a	DET
admet-2042	52	9	tube	tube	NOUN
admet-2042	52	10	containing	contain	VERB
admet-2042	52	11	3	3	NUM
admet-2042	52	12	ml	ml	NOUN
admet-2042	52	13	of	of	ADP
admet-2042	52	14	ethylenediaminetetraacetic	ethylenediaminetetraacetic	ADJ
admet-2042	52	15	acid	acid	NOUN
admet-2042	52	16	(	(	PUNCT
admet-2042	52	17	edta	edta	NOUN
admet-2042	52	18	)	)	PUNCT
admet-2042	52	19	.	.	PUNCT
admet-2042	53	1	the	the	DET
admet-2042	53	2	blood	blood	NOUN
admet-2042	53	3	samples	sample	NOUN
admet-2042	53	4	were	be	AUX
admet-2042	53	5	centrifugated	centrifugate	VERB
admet-2042	53	6	at	at	ADP
admet-2042	53	7	a	a	DET
admet-2042	53	8	speed	speed	NOUN
admet-2042	53	9	of	of	ADP
admet-2042	53	10	3000	3000	NUM
admet-2042	53	11	rpm	rpm	NOUN
admet-2042	53	12	for	for	ADP
admet-2042	53	13	10	10	NUM
admet-2042	53	14	minutes	minute	NOUN
admet-2042	53	15	to	to	PART
admet-2042	53	16	get	get	VERB
admet-2042	53	17	plasma	plasma	NOUN
admet-2042	53	18	.	.	PUNCT
admet-2042	54	1	the	the	DET
admet-2042	54	2	plasma	plasma	NOUN
admet-2042	54	3	sample	sample	NOUN
admet-2042	54	4	was	be	AUX
admet-2042	54	5	transferred	transfer	VERB
admet-2042	54	6	to	to	ADP
admet-2042	54	7	a	a	DET
admet-2042	54	8	1.5	1.5	NUM
admet-2042	54	9	ml	ml	NOUN
admet-2042	54	10	microtube	microtube	NOUN
admet-2042	54	11	as	as	ADP
admet-2042	54	12	the	the	DET
admet-2042	54	13	supernatant	supernatant	NOUN
admet-2042	54	14	.	.	PUNCT
admet-2042	55	1	the	the	DET
admet-2042	55	2	specimens	specimen	NOUN
admet-2042	55	3	were	be	AUX
admet-2042	55	4	stored	store	VERB
admet-2042	55	5	at	at	ADP
admet-2042	55	6	a	a	DET
admet-2042	55	7	temperature	temperature	NOUN
admet-2042	55	8	of	of	ADP
admet-2042	55	9	-18	-18	PROPN
admet-2042	55	10	°	°	ADP
admet-2042	55	11	c	c	NOUN
admet-2042	55	12	until	until	SCONJ
admet-2042	55	13	they	they	PRON
admet-2042	55	14	were	be	AUX
admet-2042	55	15	subjected	subject	VERB
admet-2042	55	16	to	to	ADP
admet-2042	55	17	analysis	analysis	NOUN
admet-2042	55	18	.	.	PUNCT
admet-2042	56	1	the	the	DET
admet-2042	56	2	addition	addition	NOUN
admet-2042	56	3	of	of	ADP
admet-2042	56	4	itraconazole	itraconazole	NOUN
admet-2042	56	5	as	as	ADP
admet-2042	56	6	the	the	DET
admet-2042	56	7	internal	internal	ADJ
admet-2042	56	8	standard	standard	NOUN
admet-2042	56	9	(	(	PUNCT
admet-2042	56	10	is	be	AUX
admet-2042	56	11	)	)	PUNCT
admet-2042	56	12	involved	involve	VERB
admet-2042	56	13	the	the	DET
admet-2042	56	14	placement	placement	NOUN
admet-2042	56	15	of	of	ADP
admet-2042	56	16	100	100	NUM
admet-2042	56	17	µl	µl	NOUN
admet-2042	56	18	of	of	ADP
admet-2042	56	19	the	the	PRON
admet-2042	56	20	is	be	AUX
admet-2042	56	21	into	into	ADP
admet-2042	56	22	a	a	DET
admet-2042	56	23	1.5	1.5	NUM
admet-2042	56	24	ml	ml	NOUN
admet-2042	56	25	microtube	microtube	NOUN
admet-2042	56	26	containing	contain	VERB
admet-2042	56	27	150	150	NUM
admet-2042	56	28	µl	µl	NOUN
admet-2042	56	29	of	of	ADP
admet-2042	56	30	rabbit	rabbit	NOUN
admet-2042	56	31	plasma	plasma	NOUN
admet-2042	56	32	sample	sample	NOUN
admet-2042	56	33	.	.	PUNCT
admet-2042	57	1	subsequently	subsequently	ADV
admet-2042	57	2	,	,	PUNCT
admet-2042	57	3	the	the	DET
admet-2042	57	4	sample	sample	NOUN
admet-2042	57	5	was	be	AUX
admet-2042	57	6	subjected	subject	VERB
admet-2042	57	7	to	to	ADP
admet-2042	57	8	deproteinization	deproteinization	NOUN
admet-2042	57	9	using	use	VERB
admet-2042	57	10	300	300	NUM
admet-2042	57	11	µl	µl	NOUN
admet-2042	57	12	of	of	ADP
admet-2042	57	13	acetonitrile	acetonitrile	NOUN
admet-2042	57	14	.	.	PUNCT
admet-2042	58	1	following	follow	VERB
admet-2042	58	2	vortexing	vortexe	VERB
admet-2042	58	3	for	for	ADP
admet-2042	58	4	1	1	NUM
admet-2042	58	5	minute	minute	NOUN
admet-2042	58	6	,	,	PUNCT
admet-2042	58	7	the	the	DET
admet-2042	58	8	plasma	plasma	NOUN
admet-2042	58	9	sample	sample	NOUN
admet-2042	58	10	was	be	AUX
admet-2042	58	11	centrifugated	centrifugate	VERB
admet-2042	58	12	with	with	ADP
admet-2042	58	13	12000	12000	NUM
admet-2042	58	14	g	g	NOUN
admet-2042	58	15	for	for	ADP
admet-2042	58	16	10	10	NUM
admet-2042	58	17	minutes	minute	NOUN
admet-2042	58	18	.	.	PUNCT
admet-2042	59	1	subsequently	subsequently	ADV
admet-2042	59	2	,	,	PUNCT
admet-2042	59	3	100	100	NUM
admet-2042	59	4	µl	µl	NOUN
admet-2042	59	5	of	of	ADP
admet-2042	59	6	the	the	DET
admet-2042	59	7	resulting	result	VERB
admet-2042	59	8	supernatant	supernatant	NOUN
admet-2042	59	9	was	be	AUX
admet-2042	59	10	carefully	carefully	ADV
admet-2042	59	11	transferred	transfer	VERB
admet-2042	59	12	to	to	ADP
admet-2042	59	13	a	a	DET
admet-2042	59	14	sterile	sterile	ADJ
admet-2042	59	15	1.5	1.5	NUM
admet-2042	59	16	ml	ml	NOUN
admet-2042	59	17	microtube	microtube	NOUN
admet-2042	59	18	.	.	PUNCT
admet-2042	60	1	before	before	ADP
admet-2042	60	2	conducting	conduct	VERB
admet-2042	60	3	the	the	DET
admet-2042	60	4	analysis	analysis	NOUN
admet-2042	60	5	,	,	PUNCT
admet-2042	60	6	the	the	DET
admet-2042	60	7	analyte	analyte	NOUN
admet-2042	60	8	underwent	underwent	NOUN
admet-2042	60	9	filtration	filtration	NOUN
admet-2042	60	10	using	use	VERB
admet-2042	60	11	a	a	DET
admet-2042	60	12	membrane	membrane	NOUN
admet-2042	60	13	filter	filter	NOUN
admet-2042	60	14	with	with	ADP
admet-2042	60	15	a	a	DET
admet-2042	60	16	pore	pore	ADJ
admet-2042	60	17	size	size	NOUN
admet-2042	60	18	of	of	ADP
admet-2042	60	19	0.45	0.45	NUM
admet-2042	60	20	µm	µm	NOUN
admet-2042	60	21	.	.	PUNCT
admet-2042	61	1	the	the	DET
admet-2042	61	2	concentration	concentration	NOUN
admet-2042	61	3	in	in	ADP
admet-2042	61	4	the	the	DET
admet-2042	61	5	supernatant	supernatant	NOUN
admet-2042	61	6	was	be	AUX
admet-2042	61	7	assessed	assess	VERB
admet-2042	61	8	by	by	ADP
admet-2042	61	9	employing	employ	VERB
admet-2042	61	10	the	the	DET
admet-2042	61	11	rp	rp	NOUN
admet-2042	61	12	-	-	PUNCT
admet-2042	61	13	hplc	hplc	NOUN
admet-2042	61	14	technique	technique	NOUN
admet-2042	61	15	for	for	ADP
admet-2042	61	16	analysis	analysis	NOUN
admet-2042	61	17	(	(	PUNCT
admet-2042	61	18	figure	figure	NOUN
admet-2042	61	19	1	1	NUM
admet-2042	61	20	)	)	PUNCT
admet-2042	61	21	.	.	PUNCT
admet-2042	62	1	figure	figure	NOUN
admet-2042	62	2	1	1	NUM
admet-2042	62	3	.	.	PUNCT
admet-2042	63	1	preparation	preparation	NOUN
admet-2042	63	2	of	of	ADP
admet-2042	63	3	blood	blood	NOUN
admet-2042	63	4	plasma	plasma	NOUN
admet-2042	63	5	rabbit	rabbit	NOUN
admet-2042	63	6	before	before	ADP
admet-2042	63	7	analysis	analysis	NOUN
admet-2042	63	8	using	use	VERB
admet-2042	63	9	rp	rp	NOUN
admet-2042	63	10	-	-	PUNCT
admet-2042	63	11	hplc	hplc	NOUN
admet-2042	63	12	.	.	PUNCT
admet-2042	64	1	analytical	analytical	ADJ
admet-2042	64	2	method	method	NOUN
admet-2042	64	3	the	the	DET
admet-2042	64	4	method	method	NOUN
admet-2042	64	5	has	have	AUX
admet-2042	64	6	been	be	AUX
admet-2042	64	7	validated	validate	VERB
admet-2042	64	8	with	with	ADP
admet-2042	64	9	the	the	DET
admet-2042	64	10	result	result	NOUN
admet-2042	64	11	of	of	ADP
admet-2042	64	12	linearity	linearity	NOUN
admet-2042	64	13	in	in	ADP
admet-2042	64	14	the	the	DET
admet-2042	64	15	0.05	0.05	NUM
admet-2042	64	16	-	-	SYM
admet-2042	64	17	8	8	NUM
admet-2042	64	18	µg	µg	NOUN
admet-2042	64	19	ml-1	ml-1	ADV
admet-2042	64	20	with	with	ADP
admet-2042	64	21	r2=0.9969	r2=0.9969	PROPN
admet-2042	64	22	and	and	CCONJ
admet-2042	64	23	lloq	lloq	PROPN
admet-2042	64	24	is	be	AUX
admet-2042	64	25	0.05	0.05	NUM
admet-2042	64	26	µg	µg	ADP
admet-2042	64	27	ml-1	ml-1	PUNCT
admet-2042	65	1	[	[	X
admet-2042	65	2	11	11	NUM
admet-2042	65	3	]	]	PUNCT
admet-2042	65	4	.	.	PUNCT
admet-2042	66	1	the	the	DET
admet-2042	66	2	experimental	experimental	ADJ
admet-2042	66	3	setup	setup	NOUN
admet-2042	66	4	included	include	VERB
admet-2042	66	5	an	an	DET
admet-2042	66	6	elite	elite	ADJ
admet-2042	66	7	lachrom	lachrom	ADJ
admet-2042	66	8	high	high	ADJ
admet-2042	66	9	-	-	PUNCT
admet-2042	66	10	performance	performance	NOUN
admet-2042	66	11	liquid	liquid	ADJ
admet-2042	66	12	chromategraphy	chromategraphy	NOUN
admet-2042	66	13	(	(	PUNCT
admet-2042	66	14	hplc	hplc	NOUN
admet-2042	66	15	)	)	PUNCT
admet-2042	66	16	system	system	NOUN
admet-2042	66	17	,	,	PUNCT
admet-2042	66	18	a	a	DET
admet-2042	66	19	hitachi	hitachi	PROPN
admet-2042	66	20	uv	uv	NOUN
admet-2042	66	21	-	-	PUNCT
admet-2042	66	22	vis	vis	X
admet-2042	66	23	detector	detector	NOUN
admet-2042	66	24	l-2420	l-2420	PROPN
admet-2042	66	25	,	,	PUNCT
admet-2042	66	26	and	and	CCONJ
admet-2042	66	27	a	a	DET
admet-2042	66	28	hitachi	hitachi	PROPN
admet-2042	66	29	pump	pump	NOUN
admet-2042	66	30	l-2130	l-2130	PROPN
admet-2042	66	31	.	.	PUNCT
admet-2042	67	1	a	a	DET
admet-2042	67	2	phenomenex	phenomenex	ADV
admet-2042	67	3	luna	luna	PROPN
admet-2042	67	4	column	column	NOUN
admet-2042	67	5	with	with	ADP
admet-2042	67	6	dimensions	dimension	NOUN
admet-2042	67	7	of	of	ADP
admet-2042	67	8	250×4.6	250×4.6	NUM
admet-2042	67	9	mm	mm	NOUN
admet-2042	67	10	and	and	CCONJ
admet-2042	67	11	a	a	DET
admet-2042	67	12	particle	particle	NOUN
admet-2042	67	13	size	size	NOUN
admet-2042	67	14	of	of	ADP
admet-2042	67	15	5	5	NUM
admet-2042	67	16	µm	µm	NOUN
admet-2042	67	17	was	be	AUX
admet-2042	67	18	utilized	utilize	VERB
admet-2042	67	19	.	.	PUNCT
admet-2042	68	1	the	the	DET
admet-2042	68	2	mobile	mobile	ADJ
admet-2042	68	3	phase	phase	NOUN
admet-2042	68	4	utilized	utilize	VERB
admet-2042	68	5	in	in	ADP
admet-2042	68	6	this	this	DET
admet-2042	68	7	experiment	experiment	NOUN
admet-2042	68	8	was	be	AUX
admet-2042	68	9	composed	compose	VERB
admet-2042	68	10	of	of	ADP
admet-2042	68	11	a	a	DET
admet-2042	68	12	solution	solution	NOUN
admet-2042	68	13	containing	contain	VERB
admet-2042	68	14	0.02	0.02	NUM
admet-2042	68	15	m	m	VERB
admet-2042	68	16	nah2po4	nah2po4	NOUN
admet-2042	68	17	at	at	ADP
admet-2042	68	18	a	a	DET
admet-2042	68	19	ph	ph	NOUN
admet-2042	68	20	of	of	ADP
admet-2042	68	21	7.0	7.0	NUM
admet-2042	68	22	,	,	PUNCT
admet-2042	68	23	which	which	PRON
admet-2042	68	24	was	be	AUX
admet-2042	68	25	adjusted	adjust	VERB
admet-2042	68	26	using	use	VERB
admet-2042	68	27	1	1	NUM
admet-2042	68	28	m	m	NOUN
admet-2042	68	29	naoh	naoh	NOUN
admet-2042	68	30	.	.	PUNCT
admet-2042	69	1	additionally	additionally	ADV
admet-2042	69	2	,	,	PUNCT
admet-2042	69	3	acetonitrile	acetonitrile	NOUN
admet-2042	69	4	was	be	AUX
admet-2042	69	5	included	include	VERB
admet-2042	69	6	in	in	ADP
admet-2042	69	7	the	the	DET
admet-2042	69	8	mixture	mixture	NOUN
admet-2042	69	9	at	at	ADP
admet-2042	69	10	a	a	DET
admet-2042	69	11	volume	volume	NOUN
admet-2042	69	12	ratio	ratio	NOUN
admet-2042	69	13	of	of	ADP
admet-2042	69	14	30:70	30:70	NUM
admet-2042	69	15	.	.	PUNCT
admet-2042	70	1	the	the	DET
admet-2042	70	2	flow	flow	NOUN
admet-2042	70	3	rate	rate	NOUN
admet-2042	70	4	of	of	ADP
admet-2042	70	5	the	the	DET
admet-2042	70	6	mobile	mobile	ADJ
admet-2042	70	7	phase	phase	NOUN
admet-2042	70	8	was	be	AUX
admet-2042	70	9	maintained	maintain	VERB
admet-2042	70	10	at	at	ADP
admet-2042	70	11	1	1	NUM
admet-2042	70	12	ml	ml	NOUN
admet-2042	70	13	min-1	min-1	NOUN
admet-2042	70	14	.	.	PUNCT
admet-2042	71	1	the	the	DET
admet-2042	71	2	volume	volume	NOUN
admet-2042	71	3	of	of	ADP
admet-2042	71	4	the	the	DET
admet-2042	71	5	injection	injection	NOUN
admet-2042	71	6	was	be	AUX
admet-2042	71	7	20	20	NUM
admet-2042	71	8	µl	µl	NOUN
admet-2042	71	9	.	.	PUNCT
admet-2042	72	1	the	the	PRON
admet-2042	72	2	cellulose	cellulose	NOUN
admet-2042	72	3	0.45	0.45	NUM
admet-2042	72	4	µm	µm	ADP
admet-2042	72	5	membrane	membrane	NOUN
admet-2042	72	6	filter	filter	NOUN
admet-2042	72	7	was	be	AUX
admet-2042	72	8	employed	employ	VERB
admet-2042	72	9	to	to	PART
admet-2042	72	10	filter	filter	VERB
admet-2042	72	11	the	the	DET
admet-2042	72	12	mobile	mobile	ADJ
admet-2042	72	13	phase	phase	NOUN
admet-2042	72	14	.	.	PUNCT
admet-2042	73	1	the	the	DET
admet-2042	73	2	retention	retention	NOUN
admet-2042	73	3	times	time	NOUN
admet-2042	73	4	for	for	ADP
admet-2042	73	5	ketoconazole	ketoconazole	NOUN
admet-2042	73	6	and	and	CCONJ
admet-2042	73	7	itraconazole	itraconazole	PROPN
admet-2042	73	8	,	,	PUNCT
admet-2042	73	9	used	use	VERB
admet-2042	73	10	as	as	ADP
admet-2042	73	11	standard	standard	ADJ
admet-2042	73	12	internal	internal	ADJ
admet-2042	73	13	compounds	compound	NOUN
admet-2042	73	14	,	,	PUNCT
admet-2042	73	15	were	be	AUX
admet-2042	73	16	around	around	ADV
admet-2042	73	17	5	5	NUM
admet-2042	73	18	and	and	CCONJ
admet-2042	73	19	11	11	NUM
admet-2042	73	20	minutes	minute	NOUN
admet-2042	73	21	,	,	PUNCT
admet-2042	73	22	respectively	respectively	ADV
admet-2042	73	23	.	.	PUNCT
admet-2042	74	1	data	datum	NOUN
admet-2042	74	2	and	and	CCONJ
admet-2042	74	3	statistical	statistical	ADJ
admet-2042	74	4	analysis	analysis	NOUN
admet-2042	74	5	the	the	DET
admet-2042	74	6	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	74	7	study	study	NOUN
admet-2042	74	8	employed	employ	VERB
admet-2042	74	9	a	a	DET
admet-2042	74	10	non	non	ADJ
admet-2042	74	11	-	-	ADJ
admet-2042	74	12	compartment	compartment	ADJ
admet-2042	74	13	analysis	analysis	NOUN
admet-2042	74	14	using	use	VERB
admet-2042	74	15	pk	pk	PROPN
admet-2042	74	16	analysis-2021r1	analysis-2021r1	PROPN
admet-2042	74	17	to	to	PART
admet-2042	74	18	calculate	calculate	VERB
admet-2042	74	19	various	various	ADJ
admet-2042	74	20	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	74	21	parameters	parameter	NOUN
admet-2042	74	22	,	,	PUNCT
admet-2042	74	23	including	include	VERB
admet-2042	74	24	total	total	ADJ
admet-2042	74	25	area	area	NOUN
admet-2042	74	26	under	under	ADP
admet-2042	74	27	the	the	DET
admet-2042	74	28	curve	curve	NOUN
admet-2042	74	29	from	from	ADP
admet-2042	74	30	time	time	NOUN
admet-2042	74	31	zero	zero	NUM
admet-2042	74	32	to	to	ADP
admet-2042	74	33	infinity	infinity	NOUN
admet-2042	74	34	(	(	PUNCT
admet-2042	74	35	auc0-∞	auc0-∞	NUM
admet-2042	74	36	)	)	PUNCT
admet-2042	74	37	,	,	PUNCT
admet-2042	74	38	the	the	DET
admet-2042	74	39	volume	volume	NOUN
admet-2042	74	40	of	of	ADP
admet-2042	74	41	distribution	distribution	NOUN
admet-2042	74	42	(	(	PUNCT
admet-2042	74	43	vd	vd	NOUN
admet-2042	74	44	f-1	f-1	NOUN
admet-2042	74	45	)	)	PUNCT
admet-2042	74	46	,	,	PUNCT
admet-2042	74	47	clearance	clearance	NOUN
admet-2042	74	48	(	(	PUNCT
admet-2042	74	49	cl	cl	NOUN
admet-2042	74	50	f-1	f-1	NOUN
admet-2042	74	51	)	)	PUNCT
admet-2042	74	52	,	,	PUNCT
admet-2042	74	53	maximum	maximum	ADJ
admet-2042	74	54	concentration	concentration	NOUN
admet-2042	74	55	(	(	PUNCT
admet-2042	74	56	cmax	cmax	NOUN
admet-2042	74	57	)	)	PUNCT
admet-2042	74	58	,	,	PUNCT
admet-2042	74	59	and	and	CCONJ
admet-2042	74	60	time	time	NOUN
admet-2042	74	61	to	to	PART
admet-2042	74	62	reach	reach	VERB
admet-2042	74	63	maximum	maximum	ADJ
admet-2042	74	64	concentration	concentration	NOUN
admet-2042	74	65	(	(	PUNCT
admet-2042	74	66	tmax	tmax	ADJ
admet-2042	74	67	)	)	PUNCT
admet-2042	74	68	.	.	PUNCT
admet-2042	75	1	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	PROPN
admet-2042	76	1	v.	v.	CCONJ
admet-2042	76	2	annisa	annisa	ADP
admet-2042	76	3	et	et	PROPN
admet-2042	76	4	al	al	PROPN
admet-2042	76	5	.	.	PROPN
admet-2042	76	6	admet	admet	PROPN
admet-2042	76	7	&	&	CCONJ
admet-2042	76	8	dmpk	dmpk	PROPN
admet-2042	76	9	12(2	12(2	NUM
admet-2042	76	10	)	)	PUNCT
admet-2042	76	11	(	(	PUNCT
admet-2042	76	12	2024	2024	NUM
admet-2042	76	13	)	)	PUNCT
admet-2042	76	14	335	335	NUM
admet-2042	76	15	-	-	SYM
admet-2042	76	16	341	341	NUM
admet-2042	76	17	338	338	NUM
admet-2042	76	18	the	the	DET
admet-2042	76	19	data	datum	NOUN
admet-2042	76	20	obtained	obtain	VERB
admet-2042	76	21	from	from	ADP
admet-2042	76	22	the	the	DET
admet-2042	76	23	parameter	parameter	NOUN
admet-2042	76	24	resulted	result	VERB
admet-2042	76	25	in	in	ADP
admet-2042	76	26	an	an	DET
admet-2042	76	27	average	average	ADJ
admet-2042	76	28	±	±	NOUN
admet-2042	76	29	standard	standard	NOUN
admet-2042	76	30	error	error	NOUN
admet-2042	76	31	of	of	ADP
admet-2042	76	32	measurement	measurement	NOUN
admet-2042	76	33	(	(	PUNCT
admet-2042	76	34	sem	sem	NOUN
admet-2042	76	35	)	)	PUNCT
admet-2042	76	36	and	and	CCONJ
admet-2042	76	37	was	be	AUX
admet-2042	76	38	analyzed	analyze	VERB
admet-2042	76	39	using	use	VERB
admet-2042	76	40	the	the	DET
admet-2042	76	41	independent	independent	ADJ
admet-2042	76	42	-	-	PUNCT
admet-2042	76	43	sample	sample	NOUN
admet-2042	76	44	t	t	NOUN
admet-2042	76	45	-	-	PUNCT
admet-2042	76	46	test	test	NOUN
admet-2042	76	47	.	.	PUNCT
admet-2042	77	1	statistically	statistically	ADV
admet-2042	77	2	significant	significant	ADJ
admet-2042	77	3	differences	difference	NOUN
admet-2042	77	4	were	be	AUX
admet-2042	77	5	seen	see	VERB
admet-2042	77	6	when	when	SCONJ
admet-2042	77	7	the	the	DET
admet-2042	77	8	p	p	NOUN
admet-2042	77	9	-	-	PUNCT
admet-2042	77	10	value	value	NOUN
admet-2042	77	11	was	be	AUX
admet-2042	77	12	less	less	ADJ
admet-2042	77	13	than	than	ADP
admet-2042	77	14	0.1	0.1	NUM
admet-2042	77	15	.	.	PUNCT
admet-2042	78	1	results	result	NOUN
admet-2042	78	2	and	and	CCONJ
admet-2042	78	3	discussion	discussion	VERB
admet-2042	78	4	the	the	DET
admet-2042	78	5	materials	material	NOUN
admet-2042	78	6	employed	employ	VERB
admet-2042	78	7	in	in	ADP
admet-2042	78	8	this	this	DET
admet-2042	78	9	investigation	investigation	NOUN
admet-2042	78	10	encompassed	encompass	VERB
admet-2042	78	11	pure	pure	ADJ
admet-2042	78	12	ketoconazole	ketoconazole	NOUN
admet-2042	78	13	powder	powder	NOUN
admet-2042	78	14	and	and	CCONJ
admet-2042	78	15	ag75	ag75	PROPN
admet-2042	78	16	ketoconazole	ketoconazole	NOUN
admet-2042	78	17	beads	bead	VERB
admet-2042	78	18	.	.	PUNCT
admet-2042	79	1	however	however	ADV
admet-2042	79	2	,	,	PUNCT
admet-2042	79	3	other	other	ADJ
admet-2042	79	4	ketoconazole	ketoconazole	NOUN
admet-2042	79	5	beads	bead	NOUN
admet-2042	79	6	were	be	AUX
admet-2042	79	7	excluded	exclude	VERB
admet-2042	79	8	from	from	ADP
admet-2042	79	9	further	further	ADJ
admet-2042	79	10	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	79	11	evaluation	evaluation	NOUN
admet-2042	79	12	due	due	ADP
admet-2042	79	13	to	to	ADP
admet-2042	79	14	their	their	PRON
admet-2042	79	15	inability	inability	NOUN
admet-2042	79	16	to	to	PART
admet-2042	79	17	impede	impede	VERB
admet-2042	79	18	ketoconazole	ketoconazole	NOUN
admet-2042	79	19	precipitation	precipitation	NOUN
admet-2042	79	20	.	.	PUNCT
admet-2042	80	1	the	the	DET
admet-2042	80	2	administration	administration	NOUN
admet-2042	80	3	of	of	ADP
admet-2042	80	4	each	each	DET
admet-2042	80	5	sample	sample	NOUN
admet-2042	80	6	was	be	AUX
admet-2042	80	7	conducted	conduct	VERB
admet-2042	80	8	by	by	ADP
admet-2042	80	9	introducing	introduce	VERB
admet-2042	80	10	it	it	PRON
admet-2042	80	11	into	into	ADP
admet-2042	80	12	the	the	DET
admet-2042	80	13	oral	oral	ADJ
admet-2042	80	14	cavity	cavity	NOUN
admet-2042	80	15	of	of	ADP
admet-2042	80	16	the	the	DET
admet-2042	80	17	rabbit	rabbit	NOUN
admet-2042	80	18	by	by	ADP
admet-2042	80	19	the	the	DET
admet-2042	80	20	utilization	utilization	NOUN
admet-2042	80	21	of	of	ADP
admet-2042	80	22	a	a	DET
admet-2042	80	23	funnel	funnel	NOUN
admet-2042	80	24	/	/	SYM
admet-2042	80	25	tube	tube	NOUN
admet-2042	80	26	.	.	PUNCT
admet-2042	81	1	subsequently	subsequently	ADV
admet-2042	81	2	,	,	PUNCT
admet-2042	81	3	a	a	DET
admet-2042	81	4	syringe	syringe	NOUN
admet-2042	81	5	supplemented	supplement	VERB
admet-2042	81	6	3	3	NUM
admet-2042	81	7	-	-	SYM
admet-2042	81	8	6	6	NUM
admet-2042	81	9	ml	ml	NOUN
admet-2042	81	10	of	of	ADP
admet-2042	81	11	water	water	NOUN
admet-2042	81	12	to	to	ADP
admet-2042	81	13	the	the	DET
admet-2042	81	14	sample	sample	NOUN
admet-2042	81	15	.	.	PUNCT
admet-2042	82	1	the	the	DET
admet-2042	82	2	administered	administer	VERB
admet-2042	82	3	ketoconazole	ketoconazole	NOUN
admet-2042	82	4	dosage	dosage	NOUN
admet-2042	82	5	was	be	AUX
admet-2042	82	6	400	400	NUM
admet-2042	82	7	mg	mg	NOUN
admet-2042	82	8	,	,	PUNCT
admet-2042	82	9	subsequently	subsequently	ADV
admet-2042	82	10	translated	translate	VERB
admet-2042	82	11	into	into	ADP
admet-2042	82	12	a	a	DET
admet-2042	82	13	rabbit	rabbit	NOUN
admet-2042	82	14	-	-	PUNCT
admet-2042	82	15	specific	specific	ADJ
admet-2042	82	16	dosage	dosage	NOUN
admet-2042	82	17	of	of	ADP
admet-2042	82	18	18.67	18.67	NUM
admet-2042	82	19	mg	mg	NOUN
admet-2042	82	20	per	per	ADP
admet-2042	82	21	kilogram	kilogram	PROPN
admet-2042	82	22	of	of	ADP
admet-2042	82	23	body	body	NOUN
admet-2042	82	24	weight	weight	NOUN
admet-2042	82	25	.	.	PUNCT
admet-2042	83	1	the	the	DET
admet-2042	83	2	selection	selection	NOUN
admet-2042	83	3	of	of	ADP
admet-2042	83	4	the	the	DET
admet-2042	83	5	400	400	NUM
admet-2042	83	6	mg	mg	NOUN
admet-2042	83	7	dose	dose	VERB
admet-2042	83	8	over	over	ADP
admet-2042	83	9	the	the	DET
admet-2042	83	10	200	200	NUM
admet-2042	83	11	mg	mg	NOUN
admet-2042	83	12	dose	dose	NOUN
admet-2042	83	13	was	be	AUX
admet-2042	83	14	made	make	VERB
admet-2042	83	15	in	in	ADP
admet-2042	83	16	order	order	NOUN
admet-2042	83	17	to	to	PART
admet-2042	83	18	enhance	enhance	VERB
admet-2042	83	19	the	the	DET
admet-2042	83	20	sensitivity	sensitivity	NOUN
admet-2042	83	21	of	of	ADP
admet-2042	83	22	the	the	DET
admet-2042	83	23	testing	testing	NOUN
admet-2042	83	24	device	device	NOUN
admet-2042	83	25	in	in	ADP
admet-2042	83	26	detecting	detect	VERB
admet-2042	83	27	the	the	DET
admet-2042	83	28	drug	drug	NOUN
admet-2042	83	29	concentration	concentration	NOUN
admet-2042	83	30	within	within	ADP
admet-2042	83	31	the	the	DET
admet-2042	83	32	blood	blood	NOUN
admet-2042	83	33	plasma	plasma	NOUN
admet-2042	83	34	matrix	matrix	NOUN
admet-2042	83	35	.	.	PUNCT
admet-2042	84	1	figure	figure	NOUN
admet-2042	84	2	2	2	NUM
admet-2042	84	3	shows	show	VERB
admet-2042	84	4	the	the	DET
admet-2042	84	5	concentration	concentration	NOUN
admet-2042	84	6	results	result	NOUN
admet-2042	84	7	of	of	ADP
admet-2042	84	8	purified	purified	ADJ
admet-2042	84	9	ketoconazole	ketoconazole	NOUN
admet-2042	84	10	and	and	CCONJ
admet-2042	84	11	ketoconazole	ketoconazole	PROPN
admet-2042	84	12	beads	bead	NOUN
admet-2042	84	13	obtained	obtain	VERB
admet-2042	84	14	from	from	ADP
admet-2042	84	15	blood	blood	NOUN
admet-2042	84	16	plasma	plasma	NOUN
admet-2042	84	17	at	at	ADP
admet-2042	84	18	each	each	DET
admet-2042	84	19	sampling	sample	VERB
admet-2042	84	20	time	time	NOUN
admet-2042	84	21	.	.	PUNCT
admet-2042	85	1	figure	figure	NOUN
admet-2042	85	2	2	2	NUM
admet-2042	85	3	.	.	PUNCT
admet-2042	86	1	the	the	DET
admet-2042	86	2	concentration	concentration	NOUN
admet-2042	86	3	of	of	ADP
admet-2042	86	4	ketoconazole	ketoconazole	NOUN
admet-2042	86	5	in	in	ADP
admet-2042	86	6	rabbit	rabbit	NOUN
admet-2042	86	7	plasma	plasma	NOUN
admet-2042	86	8	by	by	ADP
admet-2042	86	9	oral	oral	ADJ
admet-2042	86	10	administration	administration	NOUN
admet-2042	86	11	at	at	ADP
admet-2042	86	12	a	a	DET
admet-2042	86	13	dose	dose	NOUN
admet-2042	86	14	of	of	ADP
admet-2042	86	15	18.67	18.67	NUM
admet-2042	86	16	mg	mg	PROPN
admet-2042	86	17	kg-1	kg-1	NOUN
admet-2042	86	18	in	in	ADP
admet-2042	86	19	pure	pure	ADJ
admet-2042	86	20	ketoconazole	ketoconazole	NOUN
admet-2042	86	21	as	as	ADP
admet-2042	86	22	control	control	NOUN
admet-2042	86	23	(	(	PUNCT
admet-2042	86	24	a	a	NOUN
admet-2042	86	25	)	)	PUNCT
admet-2042	86	26	,	,	PUNCT
admet-2042	86	27	beads	bead	NOUN
admet-2042	86	28	as	as	ADP
admet-2042	86	29	formula	formula	NOUN
admet-2042	86	30	(	(	PUNCT
admet-2042	86	31	b	b	NOUN
admet-2042	86	32	)	)	PUNCT
admet-2042	86	33	,	,	PUNCT
admet-2042	86	34	overlapping	overlap	VERB
admet-2042	86	35	of	of	ADP
admet-2042	86	36	ag75	ag75	PROPN
admet-2042	86	37	(	(	PUNCT
admet-2042	86	38	alginate	alginate	NOUN
admet-2042	86	39	-	-	PUNCT
admet-2042	86	40	gum	gum	NOUN
admet-2042	86	41	acacia	acacia	NOUN
admet-2042	86	42	75:25	75:25	NUM
admet-2042	86	43	)	)	PUNCT
admet-2042	86	44	and	and	CCONJ
admet-2042	86	45	ktz	ktz	PROPN
admet-2042	86	46	(	(	PUNCT
admet-2042	86	47	ketoconazole	ketoconazole	NOUN
admet-2042	86	48	)	)	PUNCT
admet-2042	86	49	(	(	PUNCT
admet-2042	86	50	c	c	NOUN
admet-2042	86	51	)	)	PUNCT
admet-2042	86	52	and	and	CCONJ
admet-2042	86	53	in	in	ADP
admet-2042	86	54	semi	semi	ADJ
admet-2042	86	55	-	-	ADJ
admet-2042	86	56	log	log	ADJ
admet-2042	86	57	graph	graph	NOUN
admet-2042	86	58	(	(	PUNCT
admet-2042	86	59	d	d	NOUN
admet-2042	86	60	)	)	PUNCT
admet-2042	86	61	.	.	PUNCT
admet-2042	87	1	mean	mean	VERB
admet-2042	87	2	data	datum	NOUN
admet-2042	87	3	from	from	ADP
admet-2042	87	4	n=3±sem	n=3±sem	PROPN
admet-2042	87	5	.	.	PUNCT
admet-2042	88	1	based	base	VERB
admet-2042	88	2	on	on	ADP
admet-2042	88	3	the	the	DET
admet-2042	88	4	available	available	ADJ
admet-2042	88	5	data	datum	NOUN
admet-2042	88	6	,	,	PUNCT
admet-2042	88	7	it	it	PRON
admet-2042	88	8	is	be	AUX
admet-2042	88	9	evident	evident	ADJ
admet-2042	88	10	that	that	SCONJ
admet-2042	88	11	variability	variability	NOUN
admet-2042	88	12	exists	exist	VERB
admet-2042	88	13	across	across	ADP
admet-2042	88	14	replicates	replicate	NOUN
admet-2042	88	15	,	,	PUNCT
admet-2042	88	16	which	which	PRON
admet-2042	88	17	can	can	AUX
admet-2042	88	18	be	be	AUX
admet-2042	88	19	attributed	attribute	VERB
admet-2042	88	20	to	to	ADP
admet-2042	88	21	physiological	physiological	ADJ
admet-2042	88	22	peculiarities	peculiarity	NOUN
admet-2042	88	23	inherent	inherent	ADJ
admet-2042	88	24	to	to	ADP
admet-2042	88	25	each	each	DET
admet-2042	88	26	rabbit	rabbit	NOUN
admet-2042	88	27	.	.	PUNCT
admet-2042	89	1	furthermore	furthermore	ADV
admet-2042	89	2	,	,	PUNCT
admet-2042	89	3	administering	administer	VERB
admet-2042	89	4	drugs	drug	NOUN
admet-2042	89	5	only	only	ADV
admet-2042	89	6	through	through	ADP
admet-2042	89	7	the	the	DET
admet-2042	89	8	oral	oral	ADJ
admet-2042	89	9	route	route	NOUN
admet-2042	89	10	can	can	AUX
admet-2042	89	11	lead	lead	VERB
admet-2042	89	12	to	to	ADP
admet-2042	89	13	variations	variation	NOUN
admet-2042	89	14	in	in	ADP
admet-2042	89	15	the	the	DET
admet-2042	89	16	drug	drug	NOUN
admet-2042	89	17	's	's	PART
admet-2042	89	18	entry	entry	NOUN
admet-2042	89	19	time	time	NOUN
admet-2042	89	20	into	into	ADP
admet-2042	89	21	the	the	DET
admet-2042	89	22	gastrointestinal	gastrointestinal	ADJ
admet-2042	89	23	tract	tract	NOUN
admet-2042	89	24	,	,	PUNCT
admet-2042	89	25	allowing	allow	VERB
admet-2042	89	26	for	for	ADP
admet-2042	89	27	sufficient	sufficient	ADJ
admet-2042	89	28	time	time	NOUN
admet-2042	89	29	for	for	SCONJ
admet-2042	89	30	the	the	DET
admet-2042	89	31	rabbit	rabbit	NOUN
admet-2042	89	32	to	to	PART
admet-2042	89	33	chew	chew	VERB
admet-2042	89	34	the	the	DET
admet-2042	89	35	beads	bead	NOUN
admet-2042	89	36	before	before	ADP
admet-2042	89	37	swallowing	swallow	VERB
admet-2042	89	38	.	.	PUNCT
admet-2042	90	1	ideally	ideally	ADV
admet-2042	90	2	,	,	PUNCT
admet-2042	90	3	drug	drug	NOUN
admet-2042	90	4	administration	administration	NOUN
admet-2042	90	5	is	be	AUX
admet-2042	90	6	performed	perform	VERB
admet-2042	90	7	with	with	ADP
admet-2042	90	8	a	a	DET
admet-2042	90	9	catheter	catheter	NOUN
admet-2042	90	10	that	that	PRON
admet-2042	90	11	enables	enable	VERB
admet-2042	90	12	direct	direct	ADJ
admet-2042	90	13	oral	oral	ADJ
admet-2042	90	14	administration	administration	NOUN
admet-2042	90	15	into	into	ADP
admet-2042	90	16	the	the	DET
admet-2042	90	17	gastric	gastric	ADJ
admet-2042	90	18	cavity	cavity	NOUN
admet-2042	90	19	.	.	PUNCT
admet-2042	91	1	nevertheless	nevertheless	ADV
admet-2042	91	2	,	,	PUNCT
admet-2042	91	3	the	the	DET
admet-2042	91	4	aperture	aperture	NOUN
admet-2042	91	5	proved	prove	VERB
admet-2042	91	6	insufficient	insufficient	ADJ
admet-2042	91	7	a	a	DET
admet-2042	91	8	b	b	NOUN
admet-2042	91	9	0	0	NUM
admet-2042	91	10	0.2	0.2	NUM
admet-2042	91	11	5	5	NUM
admet-2042	91	12	0.5	0.5	NUM
admet-2042	91	13	0	0	NUM
admet-2042	91	14	0.7	0.7	NUM
admet-2042	91	15	5	5	NUM
admet-2042	91	16	1.0	1.0	NUM
admet-2042	91	17	0	0	NUM
admet-2042	91	18	1.5	1.5	NUM
admet-2042	91	19	2.0	2.0	NUM
admet-2042	91	20	2.5	2.5	NUM
admet-2042	91	21	3.0	3.0	NUM
admet-2042	91	22	4.0	4.0	NUM
admet-2042	91	23	5.0	5.0	NUM
admet-2042	91	24	6.0	6.0	NUM
admet-2042	91	25	7.0	7.0	NUM
admet-2042	91	26	0	0	NUM
admet-2042	91	27	2	2	NUM
admet-2042	91	28	4	4	NUM
admet-2042	91	29	6	6	NUM
admet-2042	91	30	time	time	NOUN
admet-2042	91	31	,	,	PUNCT
admet-2042	91	32	h	h	NOUN
admet-2042	92	1	c	c	NOUN
admet-2042	92	2	/µ	/µ	PUNCT
admet-2042	93	1	g	g	PROPN
admet-2042	93	2	m	m	PROPN
admet-2042	93	3	l-1	l-1	NOUN
admet-2042	93	4	0	0	NUM
admet-2042	93	5	0.2	0.2	NUM
admet-2042	93	6	5	5	NUM
admet-2042	93	7	0.5	0.5	NUM
admet-2042	93	8	0	0	NUM
admet-2042	93	9	0.7	0.7	NUM
admet-2042	93	10	5	5	NUM
admet-2042	93	11	1.0	1.0	NUM
admet-2042	93	12	0	0	NUM
admet-2042	93	13	1.5	1.5	NUM
admet-2042	93	14	2.0	2.0	NUM
admet-2042	93	15	2.5	2.5	NUM
admet-2042	93	16	3.0	3.0	NUM
admet-2042	93	17	4.0	4.0	NUM
admet-2042	93	18	5.0	5.0	NUM
admet-2042	93	19	6.0	6.0	NUM
admet-2042	93	20	7.0	7.0	NUM
admet-2042	93	21	0	0	NUM
admet-2042	93	22	2	2	NUM
admet-2042	93	23	4	4	NUM
admet-2042	93	24	6	6	NUM
admet-2042	93	25	time	time	NOUN
admet-2042	93	26	,	,	PUNCT
admet-2042	93	27	h	h	NOUN
admet-2042	94	1	c	c	NOUN
admet-2042	94	2	/µ	/µ	PUNCT
admet-2042	95	1	g	g	PROPN
admet-2042	95	2	m	m	PROPN
admet-2042	96	1	l-1	l-1	NOUN
admet-2042	96	2	c	c	PROPN
admet-2042	97	1	d	d	SYM
admet-2042	97	2	0	0	NUM
admet-2042	97	3	0.2	0.2	NUM
admet-2042	97	4	5	5	NUM
admet-2042	97	5	0.5	0.5	NUM
admet-2042	97	6	0	0	NUM
admet-2042	97	7	0.7	0.7	NUM
admet-2042	97	8	5	5	NUM
admet-2042	97	9	1.0	1.0	NUM
admet-2042	97	10	0	0	NUM
admet-2042	97	11	1.5	1.5	NUM
admet-2042	97	12	2.0	2.0	NUM
admet-2042	97	13	2.5	2.5	NUM
admet-2042	97	14	3.0	3.0	NUM
admet-2042	97	15	4.0	4.0	NUM
admet-2042	97	16	5.0	5.0	NUM
admet-2042	97	17	6.0	6.0	NUM
admet-2042	97	18	7.0	7.0	NUM
admet-2042	97	19	0	0	NUM
admet-2042	97	20	1	1	NUM
admet-2042	97	21	2	2	NUM
admet-2042	97	22	3	3	NUM
admet-2042	97	23	4	4	NUM
admet-2042	97	24	5	5	NUM
admet-2042	97	25	time	time	NOUN
admet-2042	97	26	,	,	PUNCT
admet-2042	97	27	h	h	NOUN
admet-2042	97	28	c	c	NOUN
admet-2042	97	29	/µ	/µ	PUNCT
admet-2042	98	1	g	g	PROPN
admet-2042	98	2	m	m	NOUN
admet-2042	98	3	l-1	l-1	NOUN
admet-2042	99	1	ag75	ag75	PROPN
admet-2042	99	2	ktz	ktz	PROPN
admet-2042	99	3	0	0	NUM
admet-2042	99	4	0.2	0.2	NUM
admet-2042	99	5	5	5	NUM
admet-2042	99	6	0.5	0.5	NUM
admet-2042	99	7	0	0	NUM
admet-2042	99	8	0.7	0.7	NUM
admet-2042	99	9	5	5	NUM
admet-2042	99	10	1.0	1.0	NUM
admet-2042	99	11	0	0	NUM
admet-2042	99	12	1.5	1.5	NUM
admet-2042	99	13	2.0	2.0	NUM
admet-2042	99	14	2.5	2.5	NUM
admet-2042	99	15	3.0	3.0	NUM
admet-2042	99	16	4.0	4.0	NUM
admet-2042	99	17	5.0	5.0	NUM
admet-2042	99	18	6.0	6.0	NUM
admet-2042	99	19	7.0	7.0	NUM
admet-2042	99	20	0.1	0.1	NUM
admet-2042	99	21	1	1	NUM
admet-2042	99	22	10	10	NUM
admet-2042	99	23	time	time	NOUN
admet-2042	99	24	,	,	PUNCT
admet-2042	99	25	h	h	NOUN
admet-2042	99	26	lo	lo	PROPN
admet-2042	99	27	g	g	PROPN
admet-2042	99	28	(	(	PUNCT
admet-2042	99	29	c	c	NOUN
admet-2042	99	30	/	/	PUNCT
admet-2042	99	31	µg	µg	NOUN
admet-2042	99	32	m	m	VERB
admet-2042	99	33	l-1	l-1	PRON
admet-2042	99	34	)	)	PUNCT
admet-2042	100	1	ag75	ag75	PROPN
admet-2042	100	2	ktz	ktz	PROPN
admet-2042	100	3	admet	admet	PROPN
admet-2042	100	4	&	&	CCONJ
admet-2042	100	5	dmpk	dmpk	PROPN
admet-2042	100	6	12(2	12(2	NUM
admet-2042	100	7	)	)	PUNCT
admet-2042	100	8	(	(	PUNCT
admet-2042	100	9	2024	2024	NUM
admet-2042	100	10	)	)	PUNCT
admet-2042	100	11	335	335	NUM
admet-2042	100	12	-	-	SYM
admet-2042	100	13	341	341	NUM
admet-2042	100	14	newly	newly	ADV
admet-2042	100	15	formulated	formulate	VERB
admet-2042	100	16	beads	bead	NOUN
admet-2042	100	17	alginate	alginate	NOUN
admet-2042	100	18	/	/	SYM
admet-2042	100	19	gum	gum	NOUN
admet-2042	100	20	acacia	acacia	NOUN
admet-2042	100	21	loaded	load	VERB
admet-2042	100	22	ketoconazole	ketoconazole	NOUN
admet-2042	100	23	doi	doi	PROPN
admet-2042	100	24	:	:	PUNCT
admet-2042	100	25	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	NOUN
admet-2042	100	26	339	339	NUM
admet-2042	100	27	in	in	ADP
admet-2042	100	28	size	size	NOUN
admet-2042	100	29	,	,	PUNCT
admet-2042	100	30	impeding	impede	VERB
admet-2042	100	31	the	the	DET
admet-2042	100	32	medicine	medicine	NOUN
admet-2042	100	33	from	from	ADP
admet-2042	100	34	being	be	AUX
admet-2042	100	35	discharged	discharge	VERB
admet-2042	100	36	into	into	ADP
admet-2042	100	37	the	the	DET
admet-2042	100	38	conduit	conduit	NOUN
admet-2042	100	39	.	.	PUNCT
admet-2042	101	1	inserting	insert	VERB
admet-2042	101	2	a	a	DET
admet-2042	101	3	bigger	big	ADJ
admet-2042	101	4	tube	tube	NOUN
admet-2042	101	5	into	into	ADP
admet-2042	101	6	the	the	DET
admet-2042	101	7	rabbit	rabbit	NOUN
admet-2042	101	8	's	's	PART
admet-2042	101	9	stomach	stomach	NOUN
admet-2042	101	10	through	through	ADP
admet-2042	101	11	the	the	DET
admet-2042	101	12	mouth	mouth	NOUN
admet-2042	101	13	cavity	cavity	NOUN
admet-2042	101	14	may	may	AUX
admet-2042	101	15	provide	provide	VERB
admet-2042	101	16	challenges	challenge	NOUN
admet-2042	101	17	.	.	PUNCT
admet-2042	102	1	consequently	consequently	ADV
admet-2042	102	2	,	,	PUNCT
admet-2042	102	3	the	the	DET
admet-2042	102	4	drug	drug	NOUN
admet-2042	102	5	was	be	AUX
admet-2042	102	6	introduced	introduce	VERB
admet-2042	102	7	via	via	ADP
admet-2042	102	8	the	the	DET
admet-2042	102	9	oral	oral	ADJ
admet-2042	102	10	route	route	NOUN
admet-2042	102	11	by	by	ADP
admet-2042	102	12	use	use	NOUN
admet-2042	102	13	of	of	ADP
admet-2042	102	14	the	the	DET
admet-2042	102	15	mouthpiece	mouthpiece	NOUN
admet-2042	102	16	straight	straight	ADV
admet-2042	102	17	into	into	ADP
admet-2042	102	18	the	the	DET
admet-2042	102	19	oral	oral	ADJ
admet-2042	102	20	cavity	cavity	NOUN
admet-2042	102	21	of	of	ADP
admet-2042	102	22	the	the	DET
admet-2042	102	23	rabbit	rabbit	NOUN
admet-2042	102	24	.	.	PUNCT
admet-2042	103	1	table	table	NOUN
admet-2042	103	2	1	1	NUM
admet-2042	103	3	displays	display	VERB
admet-2042	103	4	the	the	DET
admet-2042	103	5	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	103	6	parameters	parameter	NOUN
admet-2042	103	7	examined	examine	VERB
admet-2042	103	8	,	,	PUNCT
admet-2042	103	9	encompassing	encompass	VERB
admet-2042	103	10	auc0-∞	auc0-∞	NOUN
admet-2042	103	11	,	,	PUNCT
admet-2042	103	12	cmax	cmax	NOUN
admet-2042	103	13	,	,	PUNCT
admet-2042	103	14	tmax	tmax	ADV
admet-2042	103	15	,	,	PUNCT
admet-2042	103	16	vd	vd	NOUN
admet-2042	103	17	f-1	f-1	NOUN
admet-2042	103	18	,	,	PUNCT
admet-2042	103	19	and	and	CCONJ
admet-2042	103	20	cl	cl	NOUN
admet-2042	103	21	f-1	f-1	NOUN
admet-2042	103	22	.	.	PUNCT
admet-2042	104	1	the	the	DET
admet-2042	104	2	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	104	3	properties	property	NOUN
admet-2042	104	4	of	of	ADP
admet-2042	104	5	the	the	DET
admet-2042	104	6	control	control	NOUN
admet-2042	104	7	drug	drug	NOUN
admet-2042	104	8	and	and	CCONJ
admet-2042	104	9	formula	formula	NOUN
admet-2042	104	10	were	be	AUX
admet-2042	104	11	examined	examine	VERB
admet-2042	104	12	and	and	CCONJ
admet-2042	104	13	compared	compare	VERB
admet-2042	104	14	using	use	VERB
admet-2042	104	15	an	an	DET
admet-2042	104	16	independent	independent	ADJ
admet-2042	104	17	sample	sample	NOUN
admet-2042	104	18	ttest	ttest	NOUN
admet-2042	104	19	at	at	ADP
admet-2042	104	20	a	a	DET
admet-2042	104	21	confidence	confidence	NOUN
admet-2042	104	22	level	level	NOUN
admet-2042	104	23	of	of	ADP
admet-2042	104	24	90	90	NUM
admet-2042	104	25	%	%	NOUN
admet-2042	104	26	.	.	PUNCT
admet-2042	105	1	the	the	DET
admet-2042	105	2	results	result	NOUN
admet-2042	105	3	demonstrated	demonstrate	VERB
admet-2042	105	4	statistically	statistically	ADV
admet-2042	105	5	significant	significant	ADJ
admet-2042	105	6	differences	difference	NOUN
admet-2042	105	7	in	in	ADP
admet-2042	105	8	the	the	DET
admet-2042	105	9	auc	auc	NOUN
admet-2042	105	10	and	and	CCONJ
admet-2042	105	11	cl	cl	NOUN
admet-2042	105	12	f-1	f-1	NOUN
admet-2042	105	13	values	value	NOUN
admet-2042	105	14	.	.	PUNCT
admet-2042	106	1	however	however	ADV
admet-2042	106	2	,	,	PUNCT
admet-2042	106	3	no	no	DET
admet-2042	106	4	statistically	statistically	ADV
admet-2042	106	5	significant	significant	ADJ
admet-2042	106	6	variances	variance	NOUN
admet-2042	106	7	were	be	AUX
admet-2042	106	8	seen	see	VERB
admet-2042	106	9	in	in	ADP
admet-2042	106	10	the	the	DET
admet-2042	106	11	remaining	remain	VERB
admet-2042	106	12	parameters	parameter	NOUN
admet-2042	106	13	.	.	PUNCT
admet-2042	107	1	table	table	NOUN
admet-2042	107	2	1	1	NUM
admet-2042	107	3	:	:	PUNCT
admet-2042	107	4	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	107	5	parameters	parameter	NOUN
admet-2042	107	6	of	of	ADP
admet-2042	107	7	ketoconazole	ketoconazole	NOUN
admet-2042	107	8	in	in	ADP
admet-2042	107	9	rabbit	rabbit	NOUN
admet-2042	107	10	plasma	plasma	NOUN
admet-2042	107	11	by	by	ADP
admet-2042	107	12	oral	oral	ADJ
admet-2042	107	13	administration	administration	NOUN
admet-2042	107	14	at	at	ADP
admet-2042	107	15	a	a	DET
admet-2042	107	16	dose	dose	NOUN
admet-2042	107	17	of	of	ADP
admet-2042	107	18	18.67	18.67	NUM
admet-2042	107	19	mg	mg	PROPN
admet-2042	107	20	kg-1	kg-1	NOUN
admet-2042	107	21	parameter	parameter	PROPN
admet-2042	107	22	ktz	ktz	VERB
admet-2042	108	1	ag75	ag75	PROPN
admet-2042	108	2	#	#	SYM
admet-2042	108	3	1	1	NUM
admet-2042	108	4	#	#	SYM
admet-2042	108	5	2	2	NUM
admet-2042	108	6	#	#	SYM
admet-2042	108	7	3	3	NUM
admet-2042	108	8	average±sem	average±sem	PROPN
admet-2042	108	9	#	#	SYM
admet-2042	108	10	1	1	NUM
admet-2042	108	11	#	#	SYM
admet-2042	108	12	2	2	NUM
admet-2042	108	13	#	#	SYM
admet-2042	108	14	3	3	NUM
admet-2042	108	15	average±sem	average±sem	PROPN
admet-2042	108	16	auc0-∞	auc0-∞	NUM
admet-2042	108	17	,	,	PUNCT
admet-2042	108	18	h	h	NOUN
admet-2042	108	19	µg	µg	VERB
admet-2042	108	20	ml-1	ml-1	PROPN
admet-2042	108	21	*	*	PROPN
admet-2042	108	22	16.53	16.53	NUM
admet-2042	108	23	15.34	15.34	NUM
admet-2042	108	24	15.62	15.62	NUM
admet-2042	108	25	15.83±0.62	15.83±0.62	NUM
admet-2042	108	26	29.83	29.83	NUM
admet-2042	108	27	26.78	26.78	NUM
admet-2042	108	28	26.79	26.79	NUM
admet-2042	108	29	27.8±1.01	27.8±1.01	NUM
admet-2042	108	30	cmax	cmax	NOUN
admet-2042	108	31	/µg	/µg	PUNCT
admet-2042	108	32	ml-1	ml-1	ADV
admet-2042	108	33	5.69	5.69	NUM
admet-2042	108	34	5.04	5.04	NUM
admet-2042	108	35	3.37	3.37	NUM
admet-2042	108	36	4.7±0.69	4.7±0.69	NUM
admet-2042	108	37	4.76	4.76	NUM
admet-2042	108	38	5.22	5.22	NUM
admet-2042	108	39	3.49	3.49	NUM
admet-2042	108	40	4.49±0.52	4.49±0.52	NUM
admet-2042	108	41	tmax	tmax	NOUN
admet-2042	108	42	/h	/h	NOUN
admet-2042	108	43	1.5	1.5	NUM
admet-2042	108	44	1.5	1.5	NUM
admet-2042	108	45	2	2	NUM
admet-2042	108	46	1.67±0.17	1.67±0.17	NUM
admet-2042	108	47	3	3	NUM
admet-2042	108	48	1.5	1.5	NUM
admet-2042	108	49	3	3	NUM
admet-2042	108	50	2.5±0.5	2.5±0.5	NUM
admet-2042	108	51	vd	vd	NOUN
admet-2042	108	52	f-1/	f-1/	NOUN
admet-2042	108	53	ml	ml	PROPN
admet-2042	108	54	6.82	6.82	NUM
admet-2042	108	55	9.17	9.17	NUM
admet-2042	108	56	10.86	10.86	NUM
admet-2042	108	57	8.95±1.17	8.95±1.17	NUM
admet-2042	108	58	11.11	11.11	NUM
admet-2042	108	59	7.56	7.56	NUM
admet-2042	108	60	15.84	15.84	NUM
admet-2042	108	61	11.5±2.4	11.5±2.4	NUM
admet-2042	108	62	cl	cl	NOUN
admet-2042	108	63	f-1/	f-1/	NOUN
admet-2042	108	64	ml	ml	NOUN
admet-2042	108	65	h-1	h-1	NOUN
admet-2042	108	66	*	*	PUNCT
admet-2042	108	67	2.84	2.84	NUM
admet-2042	108	68	3.78	3.78	NUM
admet-2042	108	69	3.71	3.71	NUM
admet-2042	108	70	3.45±0.3	3.45±0.3	NUM
admet-2042	108	71	2.11	2.11	NUM
admet-2042	108	72	1.98	1.98	NUM
admet-2042	108	73	2.35	2.35	NUM
admet-2042	108	74	2.15±0.11	2.15±0.11	NUM
admet-2042	108	75	the	the	DET
admet-2042	108	76	parameters	parameter	NOUN
admet-2042	108	77	of	of	ADP
admet-2042	108	78	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	108	79	are	be	AUX
admet-2042	108	80	the	the	DET
admet-2042	108	81	area	area	NOUN
admet-2042	108	82	under	under	ADP
admet-2042	108	83	the	the	DET
admet-2042	108	84	curve	curve	NOUN
admet-2042	108	85	(	(	PUNCT
admet-2042	108	86	auc	auc	NOUN
admet-2042	108	87	)	)	PUNCT
admet-2042	108	88	,	,	PUNCT
admet-2042	108	89	volume	volume	NOUN
admet-2042	108	90	of	of	ADP
admet-2042	108	91	distribution	distribution	NOUN
admet-2042	108	92	(	(	PUNCT
admet-2042	108	93	vd	vd	NOUN
admet-2042	108	94	f-1	f-1	NOUN
admet-2042	108	95	)	)	PUNCT
admet-2042	108	96	,	,	PUNCT
admet-2042	108	97	clearance	clearance	NOUN
admet-2042	108	98	(	(	PUNCT
admet-2042	108	99	cl	cl	NOUN
admet-2042	108	100	f-1	f-1	NOUN
admet-2042	108	101	)	)	PUNCT
admet-2042	108	102	,	,	PUNCT
admet-2042	108	103	maximum	maximum	ADJ
admet-2042	108	104	concentration	concentration	NOUN
admet-2042	108	105	(	(	PUNCT
admet-2042	108	106	cmax	cmax	NOUN
admet-2042	108	107	)	)	PUNCT
admet-2042	108	108	,	,	PUNCT
admet-2042	108	109	and	and	CCONJ
admet-2042	108	110	time	time	NOUN
admet-2042	108	111	to	to	PART
admet-2042	108	112	reach	reach	VERB
admet-2042	108	113	maximum	maximum	ADJ
admet-2042	108	114	concentration	concentration	NOUN
admet-2042	108	115	(	(	PUNCT
admet-2042	108	116	tmax	tmax	ADV
admet-2042	108	117	)	)	PUNCT
admet-2042	108	118	.	.	PUNCT
admet-2042	109	1	the	the	DET
admet-2042	109	2	#	#	SYM
admet-2042	109	3	1	1	NUM
admet-2042	109	4	,	,	PUNCT
admet-2042	109	5	#	#	SYM
admet-2042	109	6	2	2	NUM
admet-2042	109	7	,	,	PUNCT
admet-2042	109	8	and	and	CCONJ
admet-2042	109	9	#	#	SYM
admet-2042	109	10	3	3	NUM
admet-2042	109	11	are	be	AUX
admet-2042	109	12	means	mean	NOUN
admet-2042	109	13	to	to	PART
admet-2042	109	14	replicate	replicate	VERB
admet-2042	109	15	from	from	ADP
admet-2042	109	16	the	the	DET
admet-2042	109	17	rabbits	rabbit	NOUN
admet-2042	109	18	.	.	PUNCT
admet-2042	110	1	*	*	PUNCT
admet-2042	110	2	significantly	significantly	ADV
admet-2042	110	3	different	different	ADJ
admet-2042	110	4	(	(	PUNCT
admet-2042	110	5	p	p	X
admet-2042	110	6	<	<	X
admet-2042	110	7	0.1	0.1	NUM
admet-2042	110	8	)	)	PUNCT
admet-2042	110	9	between	between	ADP
admet-2042	110	10	ag75	ag75	PROPN
admet-2042	110	11	(	(	PUNCT
admet-2042	110	12	alginate	alginate	NOUN
admet-2042	110	13	-	-	PUNCT
admet-2042	110	14	gum	gum	NOUN
admet-2042	110	15	acacia	acacia	NOUN
admet-2042	110	16	75:25	75:25	NUM
admet-2042	110	17	)	)	PUNCT
admet-2042	110	18	and	and	CCONJ
admet-2042	110	19	ktz	ktz	PROPN
admet-2042	110	20	(	(	PUNCT
admet-2042	110	21	ketoconazole	ketoconazole	NOUN
admet-2042	110	22	)	)	PUNCT
admet-2042	110	23	.	.	PUNCT
admet-2042	111	1	mean	mean	VERB
admet-2042	111	2	data	datum	NOUN
admet-2042	111	3	from	from	ADP
admet-2042	111	4	n	n	NOUN
admet-2042	111	5	=	=	SYM
admet-2042	111	6	3±sem	3±sem	NUM
admet-2042	111	7	.	.	PUNCT
admet-2042	111	8	ketoconazole	ketoconazole	PROPN
admet-2042	111	9	concentration	concentration	NOUN
admet-2042	111	10	data	datum	NOUN
admet-2042	111	11	in	in	ADP
admet-2042	111	12	blood	blood	NOUN
admet-2042	111	13	plasma	plasma	NOUN
admet-2042	111	14	was	be	AUX
admet-2042	111	15	processed	process	VERB
admet-2042	111	16	using	use	VERB
admet-2042	111	17	pk	pk	NOUN
admet-2042	111	18	-	-	PUNCT
admet-2042	111	19	analysis	analysis	NOUN
admet-2042	111	20	software	software	NOUN
admet-2042	111	21	with	with	ADP
admet-2042	111	22	noncompartment	noncompartment	PROPN
admet-2042	111	23	analysis	analysis	NOUN
admet-2042	111	24	.	.	PUNCT
admet-2042	112	1	in	in	ADP
admet-2042	112	2	this	this	DET
admet-2042	112	3	study	study	NOUN
admet-2042	112	4	,	,	PUNCT
admet-2042	112	5	the	the	DET
admet-2042	112	6	formulation	formulation	NOUN
admet-2042	112	7	group	group	NOUN
admet-2042	112	8	produced	produce	VERB
admet-2042	112	9	higher	high	ADJ
admet-2042	112	10	vd	vd	NOUN
admet-2042	112	11	f-1	f-1	NOUN
admet-2042	112	12	values	value	NOUN
admet-2042	112	13	,	,	PUNCT
admet-2042	112	14	from	from	ADP
admet-2042	112	15	8.95	8.95	NUM
admet-2042	112	16	to	to	ADP
admet-2042	112	17	11.5	11.5	NUM
admet-2042	112	18	ml	ml	NOUN
admet-2042	112	19	,	,	PUNCT
admet-2042	112	20	and	and	CCONJ
admet-2042	112	21	lower	low	ADJ
admet-2042	112	22	cl	cl	NOUN
admet-2042	112	23	f-1	f-1	NOUN
admet-2042	112	24	values	value	NOUN
admet-2042	112	25	,	,	PUNCT
admet-2042	112	26	from	from	ADP
admet-2042	112	27	3.45	3.45	NUM
admet-2042	112	28	hour	hour	NOUN
admet-2042	112	29	to	to	ADP
admet-2042	112	30	2.15	2.15	NUM
admet-2042	112	31	ml	ml	NOUN
admet-2042	112	32	h-1	h-1	NOUN
admet-2042	112	33	,	,	PUNCT
admet-2042	112	34	compared	compare	VERB
admet-2042	112	35	to	to	ADP
admet-2042	112	36	the	the	DET
admet-2042	112	37	control	control	NOUN
admet-2042	112	38	group	group	NOUN
admet-2042	112	39	.	.	PUNCT
admet-2042	113	1	the	the	DET
admet-2042	113	2	clearance	clearance	NOUN
admet-2042	113	3	of	of	ADP
admet-2042	113	4	pure	pure	ADJ
admet-2042	113	5	ketoconazole	ketoconazole	NOUN
admet-2042	113	6	400	400	NUM
admet-2042	113	7	mg	mg	ADV
admet-2042	113	8	in	in	ADP
admet-2042	113	9	the	the	DET
admet-2042	113	10	form	form	NOUN
admet-2042	113	11	of	of	ADP
admet-2042	113	12	a	a	DET
admet-2042	113	13	solution	solution	NOUN
admet-2042	113	14	preparation	preparation	NOUN
admet-2042	113	15	has	have	AUX
admet-2042	113	16	been	be	AUX
admet-2042	113	17	studied	study	VERB
admet-2042	113	18	previously	previously	ADV
admet-2042	113	19	by	by	ADP
admet-2042	113	20	huang	huang	PROPN
admet-2042	113	21	et	et	PROPN
admet-2042	113	22	al	al	PROPN
admet-2042	113	23	.	.	PUNCT
admet-2042	114	1	[	[	X
admet-2042	114	2	12	12	NUM
admet-2042	114	3	]	]	PUNCT
admet-2042	114	4	.	.	PUNCT
admet-2042	115	1	the	the	DET
admet-2042	115	2	results	result	NOUN
admet-2042	115	3	obtained	obtain	VERB
admet-2042	115	4	a	a	DET
admet-2042	115	5	clearance	clearance	NOUN
admet-2042	115	6	of	of	ADP
admet-2042	115	7	2.05	2.05	NUM
admet-2042	115	8	ml	ml	NOUN
admet-2042	115	9	h-1	h-1	NOUN
admet-2042	115	10	,	,	PUNCT
admet-2042	115	11	which	which	PRON
admet-2042	115	12	is	be	AUX
admet-2042	115	13	not	not	PART
admet-2042	115	14	much	much	ADV
admet-2042	115	15	different	different	ADJ
admet-2042	115	16	from	from	ADP
admet-2042	115	17	the	the	DET
admet-2042	115	18	results	result	NOUN
admet-2042	115	19	in	in	ADP
admet-2042	115	20	this	this	DET
admet-2042	115	21	study	study	NOUN
admet-2042	115	22	,	,	PUNCT
admet-2042	115	23	which	which	PRON
admet-2042	115	24	is	be	AUX
admet-2042	115	25	3.45	3.45	NUM
admet-2042	115	26	ml	ml	NOUN
admet-2042	115	27	h-1	h-1	NOUN
admet-2042	115	28	.	.	PUNCT
admet-2042	116	1	clearance	clearance	NOUN
admet-2042	116	2	is	be	AUX
admet-2042	116	3	defined	define	VERB
admet-2042	116	4	as	as	ADP
admet-2042	116	5	the	the	DET
admet-2042	116	6	clearance	clearance	NOUN
admet-2042	116	7	of	of	ADP
admet-2042	116	8	a	a	DET
admet-2042	116	9	drug	drug	NOUN
admet-2042	116	10	from	from	ADP
admet-2042	116	11	plasma	plasma	NOUN
admet-2042	116	12	in	in	ADP
admet-2042	116	13	a	a	DET
admet-2042	116	14	certain	certain	ADJ
admet-2042	116	15	period	period	NOUN
admet-2042	116	16	.	.	PUNCT
admet-2042	117	1	the	the	DET
admet-2042	117	2	process	process	NOUN
admet-2042	117	3	of	of	ADP
admet-2042	117	4	reducing	reduce	VERB
admet-2042	117	5	drugs	drug	NOUN
admet-2042	117	6	from	from	ADP
admet-2042	117	7	plasma	plasma	NOUN
admet-2042	117	8	can	can	AUX
admet-2042	117	9	be	be	AUX
admet-2042	117	10	through	through	ADP
admet-2042	117	11	metabolism	metabolism	NOUN
admet-2042	117	12	and	and	CCONJ
admet-2042	117	13	elimination	elimination	NOUN
admet-2042	117	14	.	.	PUNCT
admet-2042	118	1	ketoconazole	ketoconazole	PROPN
admet-2042	118	2	undergoes	undergo	VERB
admet-2042	118	3	first	first	ADJ
admet-2042	118	4	-	-	PUNCT
admet-2042	118	5	pass	pass	VERB
admet-2042	118	6	metabolism	metabolism	NOUN
admet-2042	118	7	in	in	ADP
admet-2042	118	8	the	the	DET
admet-2042	118	9	liver	liver	NOUN
admet-2042	118	10	and	and	CCONJ
admet-2042	118	11	gastrointestinal	gastrointestinal	ADJ
admet-2042	118	12	tract	tract	NOUN
admet-2042	118	13	,	,	PUNCT
admet-2042	118	14	which	which	PRON
admet-2042	118	15	occurs	occur	VERB
admet-2042	118	16	extensively	extensively	ADV
admet-2042	118	17	after	after	ADP
admet-2042	118	18	absorption	absorption	NOUN
admet-2042	118	19	[	[	X
admet-2042	118	20	12,13	12,13	NUM
admet-2042	118	21	]	]	PUNCT
admet-2042	118	22	.	.	PUNCT
admet-2042	119	1	ketoconazole	ketoconazole	PROPN
admet-2042	119	2	is	be	AUX
admet-2042	119	3	excreted	excrete	VERB
admet-2042	119	4	in	in	ADP
admet-2042	119	5	feces	fece	NOUN
admet-2042	119	6	through	through	ADP
admet-2042	119	7	bile	bile	NOUN
admet-2042	119	8	as	as	ADV
admet-2042	119	9	much	much	ADJ
admet-2042	119	10	as	as	ADP
admet-2042	119	11	20	20	NUM
admet-2042	119	12	to	to	PART
admet-2042	119	13	65	65	NUM
admet-2042	119	14	%	%	NOUN
admet-2042	119	15	,	,	PUNCT
admet-2042	119	16	while	while	SCONJ
admet-2042	119	17	in	in	ADP
admet-2042	119	18	urine	urine	NOUN
admet-2042	119	19	,	,	PUNCT
admet-2042	119	20	only	only	ADV
admet-2042	119	21	2	2	NUM
admet-2042	119	22	to	to	PART
admet-2042	119	23	4	4	NUM
admet-2042	119	24	%	%	NOUN
admet-2042	120	1	[	[	X
admet-2042	120	2	13,14	13,14	NUM
admet-2042	120	3	]	]	X
admet-2042	120	4	.	.	PUNCT
admet-2042	121	1	the	the	DET
admet-2042	121	2	beads	bead	NOUN
admet-2042	121	3	form	form	NOUN
admet-2042	121	4	of	of	ADP
admet-2042	121	5	ketoconazole	ketoconazole	NOUN
admet-2042	121	6	do	do	AUX
admet-2042	121	7	not	not	PART
admet-2042	121	8	affect	affect	VERB
admet-2042	121	9	ketoconazole	ketoconazole	NOUN
admet-2042	121	10	clearance	clearance	NOUN
admet-2042	121	11	.	.	PUNCT
admet-2042	122	1	the	the	DET
admet-2042	122	2	vd	vd	NOUN
admet-2042	122	3	f-1	f-1	NOUN
admet-2042	122	4	value	value	NOUN
admet-2042	122	5	is	be	AUX
admet-2042	122	6	not	not	PART
admet-2042	122	7	significantly	significantly	ADV
admet-2042	122	8	different	different	ADJ
admet-2042	122	9	between	between	ADP
admet-2042	122	10	the	the	DET
admet-2042	122	11	control	control	NOUN
admet-2042	122	12	group	group	NOUN
admet-2042	122	13	and	and	CCONJ
admet-2042	122	14	the	the	DET
admet-2042	122	15	formulation	formulation	NOUN
admet-2042	122	16	,	,	PUNCT
admet-2042	122	17	so	so	SCONJ
admet-2042	122	18	it	it	PRON
admet-2042	122	19	can	can	AUX
admet-2042	122	20	be	be	AUX
admet-2042	122	21	said	say	VERB
admet-2042	122	22	that	that	SCONJ
admet-2042	122	23	the	the	DET
admet-2042	122	24	shape	shape	NOUN
admet-2042	122	25	of	of	ADP
admet-2042	122	26	ketoconazole	ketoconazole	NOUN
admet-2042	122	27	beads	bead	NOUN
admet-2042	122	28	does	do	AUX
admet-2042	122	29	not	not	PART
admet-2042	122	30	affect	affect	VERB
admet-2042	122	31	the	the	DET
admet-2042	122	32	volume	volume	NOUN
admet-2042	122	33	of	of	ADP
admet-2042	122	34	distribution	distribution	NOUN
admet-2042	122	35	of	of	ADP
admet-2042	122	36	ketoconazole	ketoconazole	NOUN
admet-2042	122	37	.	.	PUNCT
admet-2042	123	1	the	the	DET
admet-2042	123	2	volume	volume	NOUN
admet-2042	123	3	of	of	ADP
admet-2042	123	4	distribution	distribution	NOUN
admet-2042	123	5	depends	depend	VERB
admet-2042	123	6	on	on	ADP
admet-2042	123	7	the	the	DET
admet-2042	123	8	binding	binding	NOUN
admet-2042	123	9	in	in	ADP
admet-2042	123	10	plasma	plasma	NOUN
admet-2042	123	11	and	and	CCONJ
admet-2042	123	12	tissue	tissue	NOUN
admet-2042	123	13	,	,	PUNCT
admet-2042	123	14	the	the	DET
admet-2042	123	15	accessibility	accessibility	NOUN
admet-2042	123	16	of	of	ADP
admet-2042	123	17	cells	cell	NOUN
admet-2042	123	18	,	,	PUNCT
admet-2042	123	19	and	and	CCONJ
admet-2042	123	20	its	its	PRON
admet-2042	123	21	partitioning	partitioning	NOUN
admet-2042	123	22	into	into	ADP
admet-2042	123	23	lipids	lipid	NOUN
admet-2042	123	24	[	[	X
admet-2042	123	25	15	15	NUM
admet-2042	123	26	]	]	PUNCT
admet-2042	123	27	.	.	PUNCT
admet-2042	124	1	the	the	DET
admet-2042	124	2	measured	measured	ADJ
admet-2042	124	3	volume	volume	NOUN
admet-2042	124	4	of	of	ADP
admet-2042	124	5	distribution	distribution	NOUN
admet-2042	124	6	is	be	AUX
admet-2042	124	7	the	the	DET
admet-2042	124	8	unbound	unbound	NOUN
admet-2042	124	9	form	form	NOUN
admet-2042	124	10	in	in	ADP
admet-2042	124	11	plasma	plasma	NOUN
admet-2042	124	12	.	.	PUNCT
admet-2042	125	1	ketoconazole	ketoconazole	PROPN
admet-2042	125	2	is	be	AUX
admet-2042	125	3	99	99	NUM
admet-2042	125	4	%	%	NOUN
admet-2042	125	5	bound	bind	VERB
admet-2042	125	6	and	and	CCONJ
admet-2042	125	7	only	only	ADV
admet-2042	125	8	1	1	NUM
admet-2042	125	9	%	%	NOUN
admet-2042	125	10	free	free	ADJ
admet-2042	125	11	[	[	X
admet-2042	125	12	16	16	NUM
admet-2042	125	13	]	]	PUNCT
admet-2042	125	14	.	.	PUNCT
admet-2042	126	1	because	because	SCONJ
admet-2042	126	2	the	the	DET
admet-2042	126	3	drugs	drug	NOUN
admet-2042	126	4	used	use	VERB
admet-2042	126	5	are	be	AUX
admet-2042	126	6	the	the	DET
admet-2042	126	7	same	same	ADJ
admet-2042	126	8	,	,	PUNCT
admet-2042	126	9	the	the	DET
admet-2042	126	10	vd	vd	NOUN
admet-2042	126	11	f-1	f-1	NOUN
admet-2042	126	12	value	value	NOUN
admet-2042	126	13	of	of	ADP
admet-2042	126	14	pure	pure	ADJ
admet-2042	126	15	and	and	CCONJ
admet-2042	126	16	formulated	formulated	ADJ
admet-2042	126	17	ketoconazole	ketoconazole	NOUN
admet-2042	126	18	.	.	PUNCT
admet-2042	127	1	research	research	NOUN
admet-2042	127	2	on	on	ADP
admet-2042	127	3	vd	vd	NOUN
admet-2042	127	4	f-1	f-1	NOUN
admet-2042	127	5	ketoconazole	ketoconazole	NOUN
admet-2042	127	6	with	with	ADP
admet-2042	127	7	a	a	DET
admet-2042	127	8	dose	dose	NOUN
admet-2042	127	9	of	of	ADP
admet-2042	127	10	400	400	NUM
admet-2042	127	11	mg	mg	NOUN
admet-2042	127	12	has	have	AUX
admet-2042	127	13	not	not	PART
admet-2042	127	14	been	be	AUX
admet-2042	127	15	conducted	conduct	VERB
admet-2042	127	16	before	before	ADV
admet-2042	127	17	,	,	PUNCT
admet-2042	127	18	so	so	SCONJ
admet-2042	127	19	it	it	PRON
admet-2042	127	20	can	can	AUX
admet-2042	127	21	not	not	PART
admet-2042	127	22	be	be	AUX
admet-2042	127	23	compared	compare	VERB
admet-2042	127	24	.	.	PUNCT
admet-2042	128	1	the	the	DET
admet-2042	128	2	results	result	NOUN
admet-2042	128	3	of	of	ADP
admet-2042	128	4	statistical	statistical	ADJ
admet-2042	128	5	testing	testing	NOUN
admet-2042	128	6	of	of	ADP
admet-2042	128	7	cl	cl	NOUN
admet-2042	128	8	values	value	NOUN
admet-2042	128	9	between	between	ADP
admet-2042	128	10	control	control	NOUN
admet-2042	128	11	and	and	CCONJ
admet-2042	128	12	formulation	formulation	NOUN
admet-2042	128	13	groups	group	NOUN
admet-2042	128	14	are	be	AUX
admet-2042	128	15	significantly	significantly	ADV
admet-2042	128	16	different	different	ADJ
admet-2042	128	17	.	.	PUNCT
admet-2042	129	1	auc	auc	NOUN
admet-2042	129	2	is	be	AUX
admet-2042	129	3	inversely	inversely	ADV
admet-2042	129	4	proportional	proportional	ADJ
admet-2042	129	5	to	to	AUX
admet-2042	129	6	clearance	clearance	VERB
admet-2042	129	7	and	and	CCONJ
admet-2042	129	8	is	be	AUX
admet-2042	129	9	not	not	PART
admet-2042	129	10	significantly	significantly	ADV
admet-2042	129	11	affected	affect	VERB
admet-2042	129	12	by	by	ADP
admet-2042	129	13	the	the	DET
admet-2042	129	14	vd	vd	NOUN
admet-2042	129	15	f-1	f-1	NOUN
admet-2042	129	16	value	value	NOUN
admet-2042	129	17	[	[	X
admet-2042	129	18	17	17	NUM
admet-2042	129	19	]	]	PUNCT
admet-2042	129	20	.	.	PUNCT
admet-2042	130	1	in	in	ADP
admet-2042	130	2	the	the	DET
admet-2042	130	3	previous	previous	ADJ
admet-2042	130	4	study	study	NOUN
admet-2042	130	5	,	,	PUNCT
admet-2042	130	6	the	the	DET
admet-2042	130	7	tmax	tmax	ADJ
admet-2042	130	8	value	value	NOUN
admet-2042	130	9	of	of	ADP
admet-2042	130	10	ketoconazole	ketoconazole	NOUN
admet-2042	130	11	400	400	NUM
admet-2042	130	12	mg	mg	PROPN
admet-2042	130	13	tablets	tablet	NOUN
admet-2042	130	14	obtained	obtain	VERB
admet-2042	130	15	were	be	AUX
admet-2042	130	16	1.7	1.7	NUM
admet-2042	130	17	h	h	NOUN
admet-2042	131	1	[	[	X
admet-2042	131	2	18	18	NUM
admet-2042	131	3	]	]	PUNCT
admet-2042	131	4	,	,	PUNCT
admet-2042	131	5	1.1	1.1	NUM
admet-2042	131	6	h	h	NOUN
admet-2042	132	1	[	[	X
admet-2042	132	2	19	19	NUM
admet-2042	132	3	]	]	PUNCT
admet-2042	132	4	,	,	PUNCT
admet-2042	132	5	and	and	CCONJ
admet-2042	132	6	1.58	1.58	NUM
admet-2042	132	7	h	h	NOUN
admet-2042	133	1	[	[	X
admet-2042	133	2	20	20	NUM
admet-2042	133	3	]	]	PUNCT
admet-2042	133	4	,	,	PUNCT
admet-2042	133	5	while	while	SCONJ
admet-2042	133	6	for	for	ADP
admet-2042	133	7	ketoconazole	ketoconazole	NOUN
admet-2042	133	8	400	400	NUM
admet-2042	133	9	mg	mg	NOUN
admet-2042	133	10	solution	solution	NOUN
admet-2042	133	11	dosage	dosage	NOUN
admet-2042	133	12	was	be	AUX
admet-2042	133	13	1.08	1.08	NUM
admet-2042	133	14	h	h	NOUN
admet-2042	134	1	[	[	X
admet-2042	134	2	12	12	NUM
admet-2042	134	3	]	]	PUNCT
admet-2042	134	4	.	.	PUNCT
admet-2042	135	1	in	in	ADP
admet-2042	135	2	this	this	DET
admet-2042	135	3	study	study	NOUN
admet-2042	135	4	,	,	PUNCT
admet-2042	135	5	the	the	DET
admet-2042	135	6	tmax	tmax	NOUN
admet-2042	135	7	obtained	obtain	VERB
admet-2042	135	8	was	be	AUX
admet-2042	135	9	1.67	1.67	NUM
admet-2042	135	10	h	h	NOUN
admet-2042	135	11	for	for	ADP
admet-2042	135	12	pure	pure	ADJ
admet-2042	135	13	ketoconazole	ketoconazole	NOUN
admet-2042	135	14	powder	powder	NOUN
admet-2042	135	15	and	and	CCONJ
admet-2042	135	16	2.5	2.5	NUM
admet-2042	135	17	h	h	NOUN
admet-2042	135	18	for	for	ADP
admet-2042	135	19	ketoconazole	ketoconazole	NOUN
admet-2042	135	20	beads	bead	NOUN
admet-2042	135	21	.	.	PUNCT
admet-2042	136	1	the	the	DET
admet-2042	136	2	tmax	tmax	ADJ
admet-2042	136	3	value	value	NOUN
admet-2042	136	4	of	of	ADP
admet-2042	136	5	ketoconazole	ketoconazole	NOUN
admet-2042	136	6	beads	bead	NOUN
admet-2042	136	7	was	be	AUX
admet-2042	136	8	greater	great	ADJ
admet-2042	136	9	than	than	ADP
admet-2042	136	10	that	that	PRON
admet-2042	136	11	of	of	ADP
admet-2042	136	12	pure	pure	ADJ
admet-2042	136	13	ketoconazole	ketoconazole	NOUN
admet-2042	136	14	and	and	CCONJ
admet-2042	136	15	tablets	tablet	NOUN
admet-2042	136	16	.	.	PUNCT
admet-2042	137	1	it	it	PRON
admet-2042	137	2	indicates	indicate	VERB
admet-2042	137	3	that	that	SCONJ
admet-2042	137	4	the	the	DET
admet-2042	137	5	sustained	sustained	ADJ
admet-2042	137	6	release	release	NOUN
admet-2042	137	7	of	of	ADP
admet-2042	137	8	ketoconazole	ketoconazole	NOUN
admet-2042	137	9	is	be	AUX
admet-2042	137	10	released	release	VERB
admet-2042	137	11	,	,	PUNCT
admet-2042	137	12	so	so	SCONJ
admet-2042	137	13	the	the	DET
admet-2042	137	14	time	time	NOUN
admet-2042	137	15	required	require	VERB
admet-2042	137	16	to	to	PART
admet-2042	137	17	reach	reach	VERB
admet-2042	137	18	the	the	DET
admet-2042	137	19	maximum	maximum	ADJ
admet-2042	137	20	concentration	concentration	NOUN
admet-2042	137	21	is	be	AUX
admet-2042	137	22	longer	long	ADJ
admet-2042	137	23	.	.	PUNCT
admet-2042	138	1	however	however	ADV
admet-2042	138	2	,	,	PUNCT
admet-2042	138	3	the	the	DET
admet-2042	138	4	results	result	NOUN
admet-2042	138	5	of	of	ADP
admet-2042	138	6	statistical	statistical	ADJ
admet-2042	138	7	testing	testing	NOUN
admet-2042	138	8	of	of	ADP
admet-2042	138	9	the	the	DET
admet-2042	138	10	control	control	NOUN
admet-2042	138	11	and	and	CCONJ
admet-2042	138	12	formulation	formulation	NOUN
admet-2042	138	13	groups	group	NOUN
admet-2042	138	14	were	be	AUX
admet-2042	138	15	not	not	PART
admet-2042	138	16	significantly	significantly	ADV
admet-2042	138	17	different	different	ADJ
admet-2042	138	18	.	.	PUNCT
admet-2042	139	1	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	PROPN
admet-2042	140	1	v.	v.	CCONJ
admet-2042	140	2	annisa	annisa	ADP
admet-2042	140	3	et	et	PROPN
admet-2042	140	4	al	al	PROPN
admet-2042	140	5	.	.	PROPN
admet-2042	140	6	admet	admet	PROPN
admet-2042	140	7	&	&	CCONJ
admet-2042	140	8	dmpk	dmpk	PROPN
admet-2042	140	9	12(2	12(2	NUM
admet-2042	140	10	)	)	PUNCT
admet-2042	140	11	(	(	PUNCT
admet-2042	140	12	2024	2024	NUM
admet-2042	140	13	)	)	PUNCT
admet-2042	140	14	335	335	NUM
admet-2042	140	15	-	-	SYM
admet-2042	140	16	341	341	NUM
admet-2042	140	17	340	340	NUM
admet-2042	140	18	in	in	ADP
admet-2042	140	19	this	this	DET
admet-2042	140	20	study	study	NOUN
admet-2042	140	21	,	,	PUNCT
admet-2042	140	22	the	the	DET
admet-2042	140	23	cmax	cmax	NOUN
admet-2042	140	24	obtained	obtain	VERB
admet-2042	140	25	was	be	AUX
admet-2042	140	26	4.7	4.7	NUM
admet-2042	140	27	µg	µg	ADV
admet-2042	140	28	ml-1	ml-1	ADV
admet-2042	140	29	for	for	ADP
admet-2042	140	30	pure	pure	ADJ
admet-2042	140	31	ketoconazole	ketoconazole	NOUN
admet-2042	140	32	powder	powder	NOUN
admet-2042	140	33	and	and	CCONJ
admet-2042	140	34	4.49	4.49	NUM
admet-2042	140	35	µg	µg	ADV
admet-2042	140	36	ml-1	ml-1	ADV
admet-2042	140	37	for	for	ADP
admet-2042	140	38	ketoconazole	ketoconazole	NOUN
admet-2042	140	39	beads	bead	NOUN
admet-2042	140	40	.	.	PUNCT
admet-2042	141	1	both	both	DET
admet-2042	141	2	results	result	NOUN
admet-2042	141	3	were	be	AUX
admet-2042	141	4	not	not	PART
admet-2042	141	5	significantly	significantly	ADV
admet-2042	141	6	different	different	ADJ
admet-2042	141	7	(	(	PUNCT
admet-2042	141	8	p>0.1	p>0.1	NOUN
admet-2042	141	9	)	)	PUNCT
admet-2042	141	10	.	.	PUNCT
admet-2042	142	1	in	in	ADP
admet-2042	142	2	the	the	DET
admet-2042	142	3	previous	previous	ADJ
admet-2042	142	4	study	study	NOUN
admet-2042	142	5	,	,	PUNCT
admet-2042	142	6	the	the	DET
admet-2042	142	7	cmax	cmax	NOUN
admet-2042	142	8	value	value	NOUN
admet-2042	142	9	of	of	ADP
admet-2042	142	10	ketoconazole	ketoconazole	NOUN
admet-2042	142	11	400	400	NUM
admet-2042	142	12	mg	mg	PROPN
admet-2042	142	13	tablets	tablet	NOUN
admet-2042	142	14	obtained	obtain	VERB
admet-2042	142	15	was	be	AUX
admet-2042	142	16	7.08	7.08	NUM
admet-2042	142	17	µg	µg	ADP
admet-2042	142	18	ml-1	ml-1	NOUN
admet-2042	143	1	[	[	X
admet-2042	143	2	18	18	NUM
admet-2042	143	3	]	]	PUNCT
admet-2042	143	4	and	and	CCONJ
admet-2042	143	5	5.71	5.71	NUM
admet-2042	143	6	µg	µg	ADP
admet-2042	143	7	ml-1	ml-1	NOUN
admet-2042	144	1	[	[	X
admet-2042	144	2	20	20	NUM
admet-2042	144	3	]	]	PUNCT
admet-2042	144	4	.	.	PUNCT
admet-2042	145	1	the	the	DET
admet-2042	145	2	cmax	cmax	NOUN
admet-2042	145	3	values	value	NOUN
admet-2042	145	4	of	of	ADP
admet-2042	145	5	ketoconazole	ketoconazole	NOUN
admet-2042	145	6	beads	bead	NOUN
admet-2042	145	7	and	and	CCONJ
admet-2042	145	8	pure	pure	ADJ
admet-2042	145	9	ketoconazole	ketoconazole	NOUN
admet-2042	145	10	have	have	VERB
admet-2042	145	11	smaller	small	ADJ
admet-2042	145	12	values	value	NOUN
admet-2042	145	13	than	than	ADP
admet-2042	145	14	previous	previous	ADJ
admet-2042	145	15	studies	study	NOUN
admet-2042	145	16	.	.	PUNCT
admet-2042	146	1	it	it	PRON
admet-2042	146	2	is	be	AUX
admet-2042	146	3	in	in	ADP
admet-2042	146	4	line	line	NOUN
admet-2042	146	5	with	with	ADP
admet-2042	146	6	the	the	DET
admet-2042	146	7	resulting	result	VERB
admet-2042	146	8	auc	auc	NOUN
admet-2042	146	9	value	value	NOUN
admet-2042	146	10	and	and	CCONJ
admet-2042	146	11	is	be	AUX
admet-2042	146	12	also	also	ADV
admet-2042	146	13	smaller	small	ADJ
admet-2042	146	14	.	.	PUNCT
admet-2042	147	1	it	it	PRON
admet-2042	147	2	might	might	AUX
admet-2042	147	3	be	be	AUX
admet-2042	147	4	because	because	SCONJ
admet-2042	147	5	the	the	DET
admet-2042	147	6	drug	drug	NOUN
admet-2042	147	7	administration	administration	NOUN
admet-2042	147	8	to	to	ADP
admet-2042	147	9	rabbits	rabbit	NOUN
admet-2042	147	10	in	in	ADP
admet-2042	147	11	this	this	DET
admet-2042	147	12	study	study	NOUN
admet-2042	147	13	was	be	AUX
admet-2042	147	14	less	less	ADJ
admet-2042	147	15	than	than	ADP
admet-2042	147	16	optimal	optimal	ADJ
admet-2042	147	17	.	.	PUNCT
admet-2042	148	1	the	the	DET
admet-2042	148	2	drug	drug	NOUN
admet-2042	148	3	that	that	PRON
admet-2042	148	4	is	be	AUX
admet-2042	148	5	inserted	insert	VERB
admet-2042	148	6	directly	directly	ADV
admet-2042	148	7	through	through	ADP
admet-2042	148	8	the	the	DET
admet-2042	148	9	funnel	funnel	NOUN
admet-2042	148	10	has	have	VERB
admet-2042	148	11	the	the	DET
admet-2042	148	12	potential	potential	NOUN
admet-2042	148	13	not	not	PART
admet-2042	148	14	to	to	PART
admet-2042	148	15	be	be	AUX
admet-2042	148	16	swallowed	swallow	VERB
admet-2042	148	17	by	by	ADP
admet-2042	148	18	rabbits	rabbit	NOUN
admet-2042	148	19	.	.	PUNCT
admet-2042	149	1	there	there	PRON
admet-2042	149	2	is	be	VERB
admet-2042	149	3	also	also	ADV
admet-2042	149	4	the	the	DET
admet-2042	149	5	possibility	possibility	NOUN
admet-2042	149	6	of	of	ADP
admet-2042	149	7	residual	residual	ADJ
admet-2042	149	8	drug	drug	NOUN
admet-2042	149	9	stuck	stick	VERB
admet-2042	149	10	to	to	ADP
admet-2042	149	11	the	the	DET
admet-2042	149	12	tube	tube	NOUN
admet-2042	149	13	wall	wall	NOUN
admet-2042	149	14	to	to	PART
admet-2042	149	15	reduce	reduce	VERB
admet-2042	149	16	the	the	DET
admet-2042	149	17	amount	amount	NOUN
admet-2042	149	18	of	of	ADP
admet-2042	149	19	drug	drug	NOUN
admet-2042	149	20	administered	administer	VERB
admet-2042	149	21	.	.	PUNCT
admet-2042	150	1	conclusions	conclusion	NOUN
admet-2042	150	2	the	the	DET
admet-2042	150	3	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	150	4	profile	profile	NOUN
admet-2042	150	5	of	of	ADP
admet-2042	150	6	beads	bead	NOUN
admet-2042	150	7	ketoconazole	ketoconazole	NOUN
admet-2042	150	8	via	via	ADP
admet-2042	150	9	oral	oral	ADJ
admet-2042	150	10	route	route	NOUN
admet-2042	150	11	was	be	AUX
admet-2042	150	12	evaluated	evaluate	VERB
admet-2042	150	13	.	.	PUNCT
admet-2042	151	1	the	the	DET
admet-2042	151	2	formulation	formulation	NOUN
admet-2042	151	3	incorporating	incorporate	VERB
admet-2042	151	4	ketoconazole	ketoconazole	NOUN
admet-2042	151	5	beads	bead	NOUN
admet-2042	151	6	exhibited	exhibit	VERB
admet-2042	151	7	a	a	DET
admet-2042	151	8	higher	high	ADJ
admet-2042	151	9	auc0-∞	auc0-∞	PROPN
admet-2042	151	10	than	than	ADP
admet-2042	151	11	the	the	DET
admet-2042	151	12	pure	pure	ADJ
admet-2042	151	13	ketoconazole	ketoconazole	NOUN
admet-2042	151	14	.	.	PUNCT
admet-2042	152	1	this	this	DET
admet-2042	152	2	finding	finding	NOUN
admet-2042	152	3	suggests	suggest	VERB
admet-2042	152	4	that	that	SCONJ
admet-2042	152	5	the	the	DET
admet-2042	152	6	created	create	VERB
admet-2042	152	7	formulation	formulation	NOUN
admet-2042	152	8	has	have	AUX
admet-2042	152	9	enhanced	enhance	VERB
admet-2042	152	10	the	the	DET
admet-2042	152	11	bioavailability	bioavailability	NOUN
admet-2042	152	12	of	of	ADP
admet-2042	152	13	ketoconazole	ketoconazole	NOUN
admet-2042	152	14	.	.	PUNCT
admet-2042	153	1	ethics	ethic	NOUN
admet-2042	153	2	approval	approval	NOUN
admet-2042	153	3	and	and	CCONJ
admet-2042	153	4	consent	consent	NOUN
admet-2042	153	5	to	to	PART
admet-2042	153	6	participate	participate	VERB
admet-2042	153	7	:	:	PUNCT
admet-2042	153	8	the	the	DET
admet-2042	153	9	study	study	NOUN
admet-2042	153	10	received	receive	VERB
admet-2042	153	11	ethical	ethical	ADJ
admet-2042	153	12	clearance	clearance	NOUN
admet-2042	153	13	from	from	ADP
admet-2042	153	14	the	the	DET
admet-2042	153	15	faculty	faculty	NOUN
admet-2042	153	16	of	of	ADP
admet-2042	153	17	veterinary	veterinary	NOUN
admet-2042	153	18	at	at	ADP
admet-2042	153	19	universitas	universita	NOUN
admet-2042	153	20	gadjah	gadjah	PROPN
admet-2042	153	21	mada	mada	PROPN
admet-2042	153	22	in	in	ADP
admet-2042	153	23	indonesia	indonesia	PROPN
admet-2042	153	24	(	(	PUNCT
admet-2042	153	25	approval	approval	NOUN
admet-2042	153	26	number	number	NOUN
admet-2042	153	27	039	039	NUM
admet-2042	153	28	/	/	SYM
admet-2042	153	29	ec	ec	NOUN
admet-2042	153	30	-	-	PUNCT
admet-2042	153	31	fkh	fkh	PROPN
admet-2042	153	32	/	/	SYM
admet-2042	153	33	eks./2022	eks./2022	NOUN
admet-2042	153	34	)	)	PUNCT
admet-2042	153	35	.	.	PUNCT
admet-2042	154	1	acknowledgments	acknowledgment	NOUN
admet-2042	154	2	:	:	PUNCT
admet-2042	154	3	the	the	DET
admet-2042	154	4	authors	author	NOUN
admet-2042	154	5	would	would	AUX
admet-2042	154	6	like	like	VERB
admet-2042	154	7	to	to	PART
admet-2042	154	8	acknowledge	acknowledge	VERB
admet-2042	154	9	for	for	ADP
admet-2042	154	10	financial	financial	ADJ
admet-2042	154	11	support	support	NOUN
admet-2042	154	12	by	by	ADP
admet-2042	154	13	final	final	ADJ
admet-2042	154	14	project	project	NOUN
admet-2042	154	15	recognition	recognition	NOUN
admet-2042	154	16	grant	grant	NOUN
admet-2042	154	17	universitas	universita	NOUN
admet-2042	154	18	gadjah	gadjah	PROPN
admet-2042	154	19	mada	mada	PROPN
admet-2042	155	1	[	[	X
admet-2042	155	2	grant	grant	VERB
admet-2042	155	3	number	number	NOUN
admet-2042	155	4	5075	5075	NUM
admet-2042	155	5	/	/	SYM
admet-2042	155	6	un1.p.ii	un1.p.ii	PROPN
admet-2042	155	7	/	/	SYM
admet-2042	155	8	dit	dit	NOUN
admet-2042	155	9	-	-	PUNCT
admet-2042	155	10	lit	light	VERB
admet-2042	155	11	/	/	SYM
admet-2042	155	12	pt.01.01/2023	pt.01.01/2023	NOUN
admet-2042	155	13	]	]	PUNCT
admet-2042	155	14	.	.	PUNCT
admet-2042	156	1	conflict	conflict	NOUN
admet-2042	156	2	of	of	ADP
admet-2042	156	3	interest	interest	NOUN
admet-2042	156	4	:	:	PUNCT
admet-2042	156	5	the	the	DET
admet-2042	156	6	authors	author	NOUN
admet-2042	156	7	declare	declare	VERB
admet-2042	156	8	that	that	SCONJ
admet-2042	156	9	they	they	PRON
admet-2042	156	10	have	have	VERB
admet-2042	156	11	no	no	DET
admet-2042	156	12	conflict	conflict	NOUN
admet-2042	156	13	of	of	ADP
admet-2042	156	14	interest	interest	NOUN
admet-2042	156	15	.	.	PUNCT
admet-2042	157	1	references	reference	NOUN
admet-2042	157	2	[	[	X
admet-2042	157	3	1	1	NUM
admet-2042	157	4	]	]	PUNCT
admet-2042	157	5	a.	a.	NOUN
admet-2042	157	6	ullrich	ullrich	PROPN
admet-2042	157	7	,	,	PUNCT
admet-2042	157	8	h.a	h.a	PROPN
admet-2042	157	9	.	.	PROPN
admet-2042	157	10	schiffter	schiffter	NOUN
admet-2042	157	11	.	.	PUNCT
admet-2042	158	1	the	the	DET
admet-2042	158	2	influence	influence	NOUN
admet-2042	158	3	of	of	ADP
admet-2042	158	4	polymer	polymer	NOUN
admet-2042	158	5	excipients	excipient	NOUN
admet-2042	158	6	on	on	ADP
admet-2042	158	7	the	the	DET
admet-2042	158	8	dissolution	dissolution	NOUN
admet-2042	158	9	and	and	CCONJ
admet-2042	158	10	recrystallization	recrystallization	NOUN
admet-2042	158	11	behavior	behavior	NOUN
admet-2042	158	12	of	of	ADP
admet-2042	158	13	ketoconazole	ketoconazole	NOUN
admet-2042	158	14	:	:	PUNCT
admet-2042	158	15	application	application	NOUN
admet-2042	158	16	,	,	PUNCT
admet-2042	158	17	variation	variation	NOUN
admet-2042	158	18	and	and	CCONJ
admet-2042	158	19	practical	practical	ADJ
admet-2042	158	20	aspects	aspect	NOUN
admet-2042	158	21	of	of	ADP
admet-2042	158	22	a	a	DET
admet-2042	158	23	ph	ph	ADJ
admet-2042	158	24	shift	shift	NOUN
admet-2042	158	25	method	method	NOUN
admet-2042	158	26	.	.	PUNCT
admet-2042	159	1	european	european	PROPN
admet-2042	159	2	journal	journal	PROPN
admet-2042	159	3	of	of	ADP
admet-2042	159	4	pharmaceutics	pharmaceutic	NOUN
admet-2042	159	5	and	and	CCONJ
admet-2042	159	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2042	159	7	133	133	NUM
admet-2042	159	8	(	(	PUNCT
admet-2042	159	9	2018	2018	NUM
admet-2042	159	10	)	)	PUNCT
admet-2042	159	11	20	20	NUM
admet-2042	159	12	-	-	SYM
admet-2042	159	13	30	30	NUM
admet-2042	159	14	.	.	PUNCT
admet-2042	160	1	https://doi.org/10.1016/j.ejpb.2018.09.018	https://doi.org/10.1016/j.ejpb.2018.09.018	NOUN
admet-2042	160	2	.	.	PUNCT
admet-2042	161	1	[	[	X
admet-2042	161	2	2	2	NUM
admet-2042	161	3	]	]	PUNCT
admet-2042	161	4	c.	c.	PROPN
admet-2042	161	5	de	de	PROPN
admet-2042	161	6	c.	c.	PROPN
admet-2042	161	7	spadari	spadari	PROPN
admet-2042	161	8	,	,	PUNCT
admet-2042	161	9	l.b	l.b	PROPN
admet-2042	161	10	.	.	PROPN
admet-2042	161	11	lopes	lopes	PROPN
admet-2042	161	12	,	,	PUNCT
admet-2042	161	13	k.	k.	PROPN
admet-2042	161	14	ishida	ishida	PROPN
admet-2042	161	15	.	.	PUNCT
admet-2042	161	16	potential	potential	ADJ
admet-2042	161	17	use	use	NOUN
admet-2042	161	18	of	of	ADP
admet-2042	161	19	alginate	alginate	NOUN
admet-2042	161	20	-	-	PUNCT
admet-2042	161	21	based	base	VERB
admet-2042	161	22	carriers	carrier	NOUN
admet-2042	161	23	as	as	ADP
admet-2042	161	24	antifungal	antifungal	ADJ
admet-2042	161	25	delivery	delivery	NOUN
admet-2042	161	26	system	system	NOUN
admet-2042	161	27	.	.	PUNCT
admet-2042	162	1	frontiers	frontier	NOUN
admet-2042	162	2	in	in	ADP
admet-2042	162	3	microbiology	microbiology	NOUN
admet-2042	162	4	8	8	NUM
admet-2042	162	5	(	(	PUNCT
admet-2042	162	6	2017	2017	NUM
admet-2042	162	7	)	)	PUNCT
admet-2042	162	8	97	97	NUM
admet-2042	162	9	.	.	PUNCT
admet-2042	163	1	https://doi.org/10.3389/fmicb.2017.00097	https://doi.org/10.3389/fmicb.2017.00097	PROPN
admet-2042	163	2	.	.	PUNCT
admet-2042	164	1	[	[	X
admet-2042	164	2	3	3	X
admet-2042	164	3	]	]	PUNCT
admet-2042	164	4	s.	s.	PROPN
admet-2042	164	5	ozaki	ozaki	PROPN
admet-2042	164	6	,	,	PUNCT
admet-2042	164	7	t.	t.	PROPN
admet-2042	164	8	minamisono	minamisono	PROPN
admet-2042	164	9	,	,	PUNCT
admet-2042	164	10	t.	t.	PROPN
admet-2042	164	11	yamashita	yamashita	PROPN
admet-2042	164	12	,	,	PUNCT
admet-2042	164	13	t.	t.	PROPN
admet-2042	164	14	kato	kato	PROPN
admet-2042	164	15	,	,	PUNCT
admet-2042	164	16	i.	i.	PROPN
admet-2042	164	17	kushida	kushida	PROPN
admet-2042	164	18	.	.	PUNCT
admet-2042	165	1	supersaturation	supersaturation	NOUN
admet-2042	165	2	-	-	PUNCT
admet-2042	165	3	nucleation	nucleation	NOUN
admet-2042	165	4	behavior	behavior	NOUN
admet-2042	165	5	of	of	ADP
admet-2042	165	6	poorly	poorly	ADV
admet-2042	165	7	soluble	soluble	ADJ
admet-2042	165	8	drugs	drug	NOUN
admet-2042	165	9	and	and	CCONJ
admet-2042	165	10	its	its	PRON
admet-2042	165	11	impact	impact	NOUN
admet-2042	165	12	on	on	ADP
admet-2042	165	13	the	the	DET
admet-2042	165	14	oral	oral	ADJ
admet-2042	165	15	absorption	absorption	NOUN
admet-2042	165	16	of	of	ADP
admet-2042	165	17	drugs	drug	NOUN
admet-2042	165	18	in	in	ADP
admet-2042	165	19	thermodynamically	thermodynamically	ADV
admet-2042	165	20	highenergy	highenergy	NOUN
admet-2042	165	21	forms	form	NOUN
admet-2042	165	22	.	.	PUNCT
admet-2042	166	1	journal	journal	NOUN
admet-2042	166	2	of	of	ADP
admet-2042	166	3	pharmaceutical	pharmaceutical	PROPN
admet-2042	166	4	sciences	science	NOUN
admet-2042	166	5	101	101	NUM
admet-2042	166	6	(	(	PUNCT
admet-2042	166	7	2012	2012	NUM
admet-2042	166	8	)	)	PUNCT
admet-2042	166	9	2271	2271	NUM
admet-2042	166	10	-	-	SYM
admet-2042	166	11	2280	2280	NUM
admet-2042	166	12	.	.	PUNCT
admet-2042	167	1	https://doi.org/10.1002/jps.22760	https://doi.org/10.1002/jps.22760	NOUN
admet-2042	167	2	.	.	PUNCT
admet-2042	168	1	[	[	X
admet-2042	168	2	4	4	NUM
admet-2042	168	3	]	]	PUNCT
admet-2042	168	4	a.	a.	NOUN
admet-2042	168	5	kambayashi	kambayashi	PROPN
admet-2042	168	6	,	,	PUNCT
admet-2042	168	7	j.b	j.b	PROPN
admet-2042	168	8	.	.	PROPN
admet-2042	168	9	dressman	dressman	PROPN
admet-2042	168	10	.	.	PUNCT
admet-2042	169	1	predicting	predict	VERB
admet-2042	169	2	the	the	DET
admet-2042	169	3	changes	change	NOUN
admet-2042	169	4	in	in	ADP
admet-2042	169	5	oral	oral	ADJ
admet-2042	169	6	absorption	absorption	NOUN
admet-2042	169	7	of	of	ADP
admet-2042	169	8	weak	weak	ADJ
admet-2042	169	9	base	base	NOUN
admet-2042	169	10	drugs	drug	NOUN
admet-2042	169	11	under	under	ADP
admet-2042	169	12	elevated	elevated	ADJ
admet-2042	169	13	gastric	gastric	ADJ
admet-2042	169	14	ph	ph	NOUN
admet-2042	169	15	using	use	VERB
admet-2042	169	16	an	an	DET
admet-2042	169	17	in	in	NOUN
admet-2042	169	18	vitro	vitro	X
admet-2042	169	19	-	-	PUNCT
admet-2042	169	20	in	in	ADP
admet-2042	169	21	silico	silico	NOUN
admet-2042	169	22	-	-	PUNCT
admet-2042	169	23	in	in	ADP
admet-2042	169	24	vivo	vivo	NOUN
admet-2042	169	25	approach	approach	NOUN
admet-2042	169	26	:	:	PUNCT
admet-2042	169	27	case	case	NOUN
admet-2042	169	28	examples	example	NOUN
admet-2042	169	29	—	—	PUNCT
admet-2042	169	30	dipyridamole	dipyridamole	NOUN
admet-2042	169	31	,	,	PUNCT
admet-2042	169	32	prasugrel	prasugrel	NOUN
admet-2042	169	33	,	,	PUNCT
admet-2042	169	34	and	and	CCONJ
admet-2042	169	35	nelfinavir	nelfinavir	PROPN
admet-2042	169	36	.	.	PUNCT
admet-2042	170	1	journal	journal	PROPN
admet-2042	170	2	of	of	ADP
admet-2042	170	3	pharmaceutical	pharmaceutical	PROPN
admet-2042	170	4	sciences	science	NOUN
admet-2042	170	5	108	108	NUM
admet-2042	170	6	(	(	PUNCT
admet-2042	170	7	2019	2019	NUM
admet-2042	170	8	)	)	PUNCT
admet-2042	170	9	584	584	NUM
admet-2042	170	10	-	-	SYM
admet-2042	170	11	591	591	NUM
admet-2042	170	12	.	.	PUNCT
admet-2042	171	1	https://doi.org/10.1016/j.xphs.2018.11.008	https://doi.org/10.1016/j.xphs.2018.11.008	NOUN
admet-2042	171	2	.	.	PUNCT
admet-2042	172	1	[	[	X
admet-2042	172	2	5	5	X
admet-2042	172	3	]	]	PUNCT
admet-2042	172	4	s.	s.	PROPN
admet-2042	172	5	carlert	carlert	PROPN
admet-2042	172	6	,	,	PUNCT
admet-2042	172	7	a.	a.	NOUN
admet-2042	172	8	pålsson	pålsson	PROPN
admet-2042	172	9	,	,	PUNCT
admet-2042	172	10	g.	g.	PROPN
admet-2042	172	11	hanisch	hanisch	PROPN
admet-2042	172	12	,	,	PUNCT
admet-2042	172	13	c.	c.	PROPN
admet-2042	172	14	von	von	PROPN
admet-2042	172	15	corswant	corswant	PROPN
admet-2042	172	16	,	,	PUNCT
admet-2042	172	17	c.	c.	PROPN
admet-2042	172	18	nilsson	nilsson	PROPN
admet-2042	172	19	,	,	PUNCT
admet-2042	172	20	l.	l.	PROPN
admet-2042	172	21	lindfors	lindfors	PROPN
admet-2042	172	22	,	,	PUNCT
admet-2042	172	23	h.	h.	PROPN
admet-2042	172	24	lennernäs	lennernäs	PROPN
admet-2042	172	25	,	,	PUNCT
admet-2042	172	26	b.	b.	PROPN
admet-2042	172	27	abrahamsson	abrahamsson	PROPN
admet-2042	172	28	.	.	PUNCT
admet-2042	173	1	predicting	predict	VERB
admet-2042	173	2	intestinal	intestinal	ADJ
admet-2042	173	3	precipitation	precipitation	NOUN
admet-2042	173	4	-	-	PUNCT
admet-2042	173	5	a	a	DET
admet-2042	173	6	case	case	NOUN
admet-2042	173	7	example	example	NOUN
admet-2042	173	8	for	for	ADP
admet-2042	173	9	a	a	DET
admet-2042	173	10	basic	basic	ADJ
admet-2042	173	11	bcs	bcs	NOUN
admet-2042	173	12	class	class	NOUN
admet-2042	173	13	ii	ii	NOUN
admet-2042	173	14	drug	drug	NOUN
admet-2042	173	15	.	.	PUNCT
admet-2042	174	1	pharmaceutical	pharmaceutical	PROPN
admet-2042	174	2	research	research	NOUN
admet-2042	174	3	27	27	NUM
admet-2042	174	4	(	(	PUNCT
admet-2042	174	5	2010	2010	NUM
admet-2042	174	6	)	)	PUNCT
admet-2042	174	7	2119	2119	NUM
admet-2042	174	8	-	-	SYM
admet-2042	174	9	2130	2130	NUM
admet-2042	174	10	.	.	PUNCT
admet-2042	175	1	https://doi.org/10.1007/s11095-010-0213-8	https://doi.org/10.1007/s11095-010-0213-8	NOUN
admet-2042	175	2	.	.	PUNCT
admet-2042	176	1	[	[	X
admet-2042	176	2	6	6	NUM
admet-2042	176	3	]	]	PUNCT
admet-2042	176	4	s.	s.	PROPN
admet-2042	176	5	xua	xua	PROPN
admet-2042	176	6	,	,	PUNCT
admet-2042	176	7	w.g	w.g	PROPN
admet-2042	176	8	.	.	PROPN
admet-2042	176	9	dai	dai	PROPN
admet-2042	176	10	.	.	PROPN
admet-2042	176	11	drug	drug	PROPN
admet-2042	176	12	precipitation	precipitation	NOUN
admet-2042	176	13	inhibitors	inhibitor	NOUN
admet-2042	176	14	in	in	ADP
admet-2042	176	15	supersaturable	supersaturable	ADJ
admet-2042	176	16	formulations	formulation	NOUN
admet-2042	176	17	.	.	PUNCT
admet-2042	177	1	international	international	ADJ
admet-2042	177	2	journal	journal	PROPN
admet-2042	177	3	of	of	ADP
admet-2042	177	4	pharmaceutics	pharmaceutic	NOUN
admet-2042	177	5	453	453	NUM
admet-2042	177	6	(	(	PUNCT
admet-2042	177	7	2013	2013	NUM
admet-2042	177	8	)	)	PUNCT
admet-2042	177	9	36	36	NUM
admet-2042	177	10	-	-	SYM
admet-2042	177	11	43	43	NUM
admet-2042	177	12	.	.	PUNCT
admet-2042	178	1	https://doi.org/10.1016/j.ijpharm.2013.05.013	https://doi.org/10.1016/j.ijpharm.2013.05.013	PROPN
admet-2042	178	2	.	.	PUNCT
admet-2042	179	1	[	[	X
admet-2042	179	2	7	7	NUM
admet-2042	179	3	]	]	PUNCT
admet-2042	179	4	a.	a.	NOUN
admet-2042	179	5	hassani	hassani	PROPN
admet-2042	179	6	,	,	PUNCT
admet-2042	179	7	s.	s.	PROPN
admet-2042	179	8	mahmood	mahmood	PROPN
admet-2042	179	9	,	,	PUNCT
admet-2042	179	10	h.h	h.h	PROPN
admet-2042	179	11	.	.	PROPN
admet-2042	179	12	enezei	enezei	PROPN
admet-2042	179	13	,	,	PUNCT
admet-2042	179	14	s.a	s.a	PROPN
admet-2042	179	15	.	.	PROPN
admet-2042	179	16	hussain	hussain	PROPN
admet-2042	179	17	,	,	PUNCT
admet-2042	179	18	h.a	h.a	PROPN
admet-2042	179	19	.	.	PROPN
admet-2042	179	20	hamad	hamad	PROPN
admet-2042	179	21	,	,	PUNCT
admet-2042	179	22	a.f	a.f	PROPN
admet-2042	179	23	.	.	PROPN
admet-2042	179	24	aldoghachi	aldoghachi	PROPN
admet-2042	179	25	,	,	PUNCT
admet-2042	179	26	a.	a.	NOUN
admet-2042	179	27	hagar	hagar	PROPN
admet-2042	179	28	,	,	PUNCT
admet-2042	179	29	a.a	a.a	PROPN
admet-2042	179	30	.	.	PROPN
admet-2042	179	31	doolaanea	doolaanea	PROPN
admet-2042	179	32	,	,	PUNCT
admet-2042	179	33	w.n	w.n	PROPN
admet-2042	179	34	.	.	PROPN
admet-2042	179	35	ibrahim	ibrahim	PROPN
admet-2042	179	36	.	.	PUNCT
admet-2042	180	1	formulation	formulation	NOUN
admet-2042	180	2	,	,	PUNCT
admet-2042	180	3	characterization	characterization	NOUN
admet-2042	180	4	and	and	CCONJ
admet-2042	180	5	biological	biological	ADJ
admet-2042	180	6	activity	activity	NOUN
admet-2042	180	7	screening	screening	NOUN
admet-2042	180	8	of	of	ADP
admet-2042	180	9	sodium	sodium	NOUN
admet-2042	180	10	alginate	alginate	NOUN
admet-2042	180	11	-	-	PUNCT
admet-2042	180	12	gum	gum	NOUN
admet-2042	180	13	arabic	arabic	ADJ
admet-2042	180	14	nanoparticles	nanoparticle	NOUN
admet-2042	180	15	loaded	load	VERB
admet-2042	180	16	with	with	ADP
admet-2042	180	17	curcumin	curcumin	NOUN
admet-2042	180	18	.	.	PUNCT
admet-2042	181	1	molecules	molecule	NOUN
admet-2042	181	2	25	25	NUM
admet-2042	181	3	(	(	PUNCT
admet-2042	181	4	2020	2020	NUM
admet-2042	181	5	)	)	PUNCT
admet-2042	181	6	2244	2244	NUM
admet-2042	181	7	.	.	PUNCT
admet-2042	182	1	https://doi.org/10.3390/molecules25092244	https://doi.org/10.3390/molecules25092244	PROPN
admet-2042	182	2	.	.	PUNCT
admet-2042	183	1	[	[	X
admet-2042	183	2	8	8	X
admet-2042	183	3	]	]	PUNCT
admet-2042	183	4	v.	v.	ADP
admet-2042	183	5	annisa	annisa	NOUN
admet-2042	183	6	,	,	PUNCT
admet-2042	183	7	t.n.s	t.n.s	PROPN
admet-2042	183	8	.	.	PUNCT
admet-2042	183	9	sulaiman	sulaiman	PROPN
admet-2042	183	10	,	,	PUNCT
admet-2042	183	11	a.k	a.k	PROPN
admet-2042	183	12	.	.	PROPN
admet-2042	183	13	nugroho	nugroho	PROPN
admet-2042	183	14	,	,	PUNCT
admet-2042	183	15	a.e	a.e	PROPN
admet-2042	183	16	.	.	PROPN
admet-2042	183	17	nugroho	nugroho	PROPN
admet-2042	183	18	.	.	PUNCT
admet-2042	184	1	review	review	NOUN
admet-2042	184	2	sinergisitas	sinergisita	NOUN
admet-2042	184	3	kombinasi	kombinasi	NOUN
admet-2042	184	4	polimer	polimer	NOUN
admet-2042	184	5	alami	alami	PROPN
admet-2042	184	6	serta	serta	PROPN
admet-2042	184	7	pemanfaatan	pemanfaatan	PROPN
admet-2042	184	8	dalam	dalam	PROPN
admet-2042	184	9	formulasi	formulasi	PROPN
admet-2042	184	10	obat	obat	PROPN
admet-2042	184	11	.	.	PUNCT
admet-2042	185	1	majalah	majalah	PROPN
admet-2042	185	2	farmasetika	farmasetika	X
admet-2042	185	3	6	6	NUM
admet-2042	185	4	(	(	PUNCT
admet-2042	185	5	2021	2021	NUM
admet-2042	185	6	)	)	PUNCT
admet-2042	185	7	436	436	NUM
admet-2042	185	8	.	.	PUNCT
admet-2042	186	1	https://doi.org/10.24198/mfarmasetika.v6i5.35935	https://doi.org/10.24198/mfarmasetika.v6i5.35935	X
admet-2042	186	2	.	.	PUNCT
admet-2042	187	1	https://doi.org/10.1016/j.ejpb.2018.09.018	https://doi.org/10.1016/j.ejpb.2018.09.018	NOUN
admet-2042	187	2	https://doi.org/10.3389/fmicb.2017.00097	https://doi.org/10.3389/fmicb.2017.00097	PROPN
admet-2042	187	3	https://doi.org/10.1002/jps.22760	https://doi.org/10.1002/jps.22760	PROPN
admet-2042	187	4	https://doi.org/10.1016/j.xphs.2018.11.008	https://doi.org/10.1016/j.xphs.2018.11.008	NOUN
admet-2042	187	5	https://doi.org/10.1007/s11095-010-0213-8	https://doi.org/10.1007/s11095-010-0213-8	NOUN
admet-2042	187	6	https://doi.org/10.1016/j.ijpharm.2013.05.013	https://doi.org/10.1016/j.ijpharm.2013.05.013	NUM
admet-2042	187	7	https://doi.org/10.3390/molecules25092244	https://doi.org/10.3390/molecules25092244	NOUN
admet-2042	188	1	https://doi.org/10.24198/mfarmasetika.v6i5.35935	https://doi.org/10.24198/mfarmasetika.v6i5.35935	PROPN
admet-2042	188	2	admet	admet	PROPN
admet-2042	188	3	&	&	CCONJ
admet-2042	188	4	dmpk	dmpk	PROPN
admet-2042	188	5	12(2	12(2	NUM
admet-2042	188	6	)	)	PUNCT
admet-2042	188	7	(	(	PUNCT
admet-2042	188	8	2024	2024	NUM
admet-2042	188	9	)	)	PUNCT
admet-2042	188	10	335	335	NUM
admet-2042	188	11	-	-	SYM
admet-2042	188	12	341	341	NUM
admet-2042	188	13	newly	newly	ADV
admet-2042	188	14	formulated	formulate	VERB
admet-2042	188	15	beads	bead	NOUN
admet-2042	188	16	alginate	alginate	NOUN
admet-2042	188	17	/	/	SYM
admet-2042	188	18	gum	gum	NOUN
admet-2042	188	19	acacia	acacia	NOUN
admet-2042	188	20	loaded	load	VERB
admet-2042	188	21	ketoconazole	ketoconazole	NOUN
admet-2042	188	22	doi	doi	PROPN
admet-2042	188	23	:	:	PUNCT
admet-2042	188	24	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	NOUN
admet-2042	188	25	341	341	NUM
admet-2042	188	26	[	[	SYM
admet-2042	188	27	9	9	NUM
admet-2042	188	28	]	]	PUNCT
admet-2042	188	29	v.	v.	ADP
admet-2042	188	30	annisa	annisa	NOUN
admet-2042	188	31	,	,	PUNCT
admet-2042	188	32	t.n.s	t.n.s	PROPN
admet-2042	188	33	.	.	PUNCT
admet-2042	189	1	sulaiman	sulaiman	PROPN
admet-2042	189	2	,	,	PUNCT
admet-2042	189	3	a.k	a.k	PROPN
admet-2042	189	4	.	.	PROPN
admet-2042	189	5	nugroho	nugroho	PROPN
admet-2042	189	6	,	,	PUNCT
admet-2042	189	7	a.e	a.e	PROPN
admet-2042	189	8	.	.	PROPN
admet-2042	189	9	nugroho	nugroho	PROPN
admet-2042	189	10	.	.	PUNCT
admet-2042	190	1	characterization	characterization	NOUN
admet-2042	190	2	of	of	ADP
admet-2042	190	3	alginate	alginate	NOUN
admet-2042	190	4	with	with	ADP
admet-2042	190	5	natural	natural	ADJ
admet-2042	190	6	polymers	polymer	NOUN
admet-2042	190	7	combination	combination	NOUN
admet-2042	190	8	for	for	ADP
admet-2042	190	9	drug	drug	NOUN
admet-2042	190	10	encapsulation	encapsulation	NOUN
admet-2042	190	11	.	.	PUNCT
admet-2042	191	1	iraqi	iraqi	ADJ
admet-2042	191	2	journal	journal	PROPN
admet-2042	191	3	of	of	ADP
admet-2042	191	4	pharmaceutical	pharmaceutical	ADJ
admet-2042	191	5	sciences	science	NOUN
admet-2042	191	6	31	31	NUM
admet-2042	191	7	(	(	PUNCT
admet-2042	191	8	2022	2022	NUM
admet-2042	191	9	)	)	PUNCT
admet-2042	191	10	150	150	NUM
admet-2042	191	11	-	-	SYM
admet-2042	191	12	159	159	NUM
admet-2042	191	13	.	.	PUNCT
admet-2042	191	14	https://doi.org/10.31351/vol31iss2pp150-159	https://doi.org/10.31351/vol31iss2pp150-159	NOUN
admet-2042	191	15	.	.	PUNCT
admet-2042	192	1	[	[	X
admet-2042	192	2	10	10	NUM
admet-2042	192	3	]	]	X
admet-2042	192	4	v.	v.	ADP
admet-2042	192	5	annisa	annisa	NOUN
admet-2042	192	6	,	,	PUNCT
admet-2042	192	7	t.n.s	t.n.s	PROPN
admet-2042	192	8	.	.	PUNCT
admet-2042	193	1	sulaiman	sulaiman	PROPN
admet-2042	193	2	,	,	PUNCT
admet-2042	193	3	a.k	a.k	PROPN
admet-2042	193	4	.	.	PROPN
admet-2042	193	5	nugroho	nugroho	PROPN
admet-2042	193	6	,	,	PUNCT
admet-2042	193	7	a.e	a.e	PROPN
admet-2042	193	8	.	.	PROPN
admet-2042	193	9	nugroho	nugroho	PROPN
admet-2042	193	10	.	.	PUNCT
admet-2042	194	1	a	a	DET
admet-2042	194	2	novel	novel	ADJ
admet-2042	194	3	formulation	formulation	NOUN
admet-2042	194	4	of	of	ADP
admet-2042	194	5	ketoconazole	ketoconazole	NOUN
admet-2042	194	6	entrapped	entrap	VERB
admet-2042	194	7	in	in	ADP
admet-2042	194	8	alginate	alginate	NOUN
admet-2042	194	9	with	with	ADP
admet-2042	194	10	anionic	anionic	ADJ
admet-2042	194	11	polymer	polymer	NOUN
admet-2042	194	12	beads	bead	NOUN
admet-2042	194	13	for	for	ADP
admet-2042	194	14	solubility	solubility	NOUN
admet-2042	194	15	enhancement	enhancement	NOUN
admet-2042	194	16	:	:	PUNCT
admet-2042	194	17	preparation	preparation	NOUN
admet-2042	194	18	and	and	CCONJ
admet-2042	194	19	characterization	characterization	NOUN
admet-2042	194	20	.	.	PUNCT
admet-2042	195	1	pharmacia	pharmacia	PROPN
admet-2042	195	2	(	(	PUNCT
admet-2042	195	3	2023	2023	NUM
admet-2042	195	4	)	)	PUNCT
admet-2042	195	5	108120	108120	NUM
admet-2042	195	6	(	(	PUNCT
admet-2042	195	7	accepted	accept	VERB
admet-2042	195	8	,	,	PUNCT
admet-2042	195	9	in	in	ADP
admet-2042	195	10	press	press	NOUN
admet-2042	195	11	)	)	PUNCT
admet-2042	195	12	.	.	PUNCT
admet-2042	196	1	[	[	X
admet-2042	196	2	11	11	NUM
admet-2042	196	3	]	]	X
admet-2042	196	4	v.	v.	ADP
admet-2042	196	5	annisa	annisa	NOUN
admet-2042	196	6	,	,	PUNCT
admet-2042	196	7	t.n.s	t.n.s	PROPN
admet-2042	196	8	.	.	PUNCT
admet-2042	196	9	sulaiman	sulaiman	PROPN
admet-2042	196	10	,	,	PUNCT
admet-2042	196	11	a.k	a.k	PROPN
admet-2042	196	12	.	.	PROPN
admet-2042	196	13	nugroho	nugroho	PROPN
admet-2042	196	14	,	,	PUNCT
admet-2042	196	15	a.e	a.e	PROPN
admet-2042	196	16	.	.	PROPN
admet-2042	196	17	nugroho	nugroho	PROPN
admet-2042	196	18	.	.	PUNCT
admet-2042	197	1	validation	validation	NOUN
admet-2042	197	2	of	of	ADP
admet-2042	197	3	rp	rp	NOUN
admet-2042	197	4	-	-	PUNCT
admet-2042	197	5	hplc	hplc	NOUN
admet-2042	197	6	uv	uv	NOUN
admet-2042	197	7	method	method	NOUN
admet-2042	197	8	for	for	ADP
admet-2042	197	9	determination	determination	NOUN
admet-2042	197	10	ketoconazole	ketoconazole	NOUN
admet-2042	197	11	in	in	ADP
admet-2042	197	12	rabbit	rabbit	NOUN
admet-2042	197	13	plasma	plasma	NOUN
admet-2042	197	14	:	:	PUNCT
admet-2042	197	15	an	an	DET
admet-2042	197	16	application	application	NOUN
admet-2042	197	17	to	to	ADP
admet-2042	197	18	the	the	DET
admet-2042	197	19	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	197	20	study	study	NOUN
admet-2042	197	21	.	.	PUNCT
admet-2042	198	1	fabad	fabad	PROPN
admet-2042	198	2	journal	journal	PROPN
admet-2042	198	3	of	of	ADP
admet-2042	198	4	pharmaceutical	pharmaceutical	ADJ
admet-2042	198	5	sciences	science	NOUN
admet-2042	198	6	(	(	PUNCT
admet-2042	198	7	2023	2023	NUM
admet-2042	198	8	)	)	PUNCT
admet-2042	198	9	285	285	NUM
admet-2042	198	10	-	-	SYM
admet-2042	198	11	294	294	NUM
admet-2042	198	12	.	.	PUNCT
admet-2042	199	1	https://doi.org/10.55262/fabadeczacilik.1259636	https://doi.org/10.55262/fabadeczacilik.1259636	X
admet-2042	199	2	.	.	PUNCT
admet-2042	200	1	[	[	X
admet-2042	200	2	12	12	NUM
admet-2042	200	3	]	]	PUNCT
admet-2042	200	4	y.-c	y.-c	PROPN
admet-2042	200	5	.	.	PUNCT
admet-2042	200	6	huang	huang	PROPN
admet-2042	200	7	,	,	PUNCT
admet-2042	200	8	’	'	PUNCT
admet-2042	200	9	,	,	PUNCT
admet-2042	200	10	j.l	j.l	PROPN
admet-2042	200	11	.	.	PROPN
admet-2042	200	12	colaizzi	colaizzi	NOUN
admet-2042	200	13	,	,	PUNCT
admet-2042	200	14	’	'	PUNCT
admet-2042	200	15	,	,	PUNCT
admet-2042	200	16	r.h	r.h	PROPN
admet-2042	200	17	.	.	PROPN
admet-2042	200	18	bierman	bierman	PROPN
admet-2042	200	19	,	,	PUNCT
admet-2042	200	20	r.	r.	PROPN
admet-2042	200	21	woestenborghs	woestenborghs	PROPN
admet-2042	200	22	,	,	PUNCT
admet-2042	200	23	a.j	a.j	PROPN
admet-2042	200	24	.	.	PROPN
admet-2042	200	25	heykants3	heykants3	PROPN
admet-2042	200	26	.	.	PUNCT
admet-2042	201	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	201	2	and	and	CCONJ
admet-2042	201	3	dose	dose	NOUN
admet-2042	201	4	proportionality	proportionality	NOUN
admet-2042	201	5	of	of	ADP
admet-2042	201	6	ketoconazole	ketoconazole	NOUN
admet-2042	201	7	in	in	ADP
admet-2042	201	8	normal	normal	ADJ
admet-2042	201	9	volunteers	volunteer	NOUN
admet-2042	201	10	.	.	PUNCT
admet-2042	202	1	antimicrobial	antimicrobial	ADJ
admet-2042	202	2	agents	agent	NOUN
admet-2042	202	3	and	and	CCONJ
admet-2042	202	4	chemotherapy	chemotherapy	NOUN
admet-2042	202	5	30	30	NUM
admet-2042	202	6	(	(	PUNCT
admet-2042	202	7	1986	1986	NUM
admet-2042	202	8	)	)	PUNCT
admet-2042	202	9	206	206	NUM
admet-2042	202	10	-	-	SYM
admet-2042	202	11	210	210	NUM
admet-2042	202	12	.	.	PUNCT
admet-2042	203	1	https://doi.org/10.1128/aac.30.2.206	https://doi.org/10.1128/aac.30.2.206	NOUN
admet-2042	203	2	.	.	PUNCT
admet-2042	204	1	[	[	X
admet-2042	204	2	13	13	NUM
admet-2042	204	3	]	]	X
admet-2042	204	4	t.k	t.k	PROPN
admet-2042	204	5	.	.	PROPN
admet-2042	204	6	daneshmend	daneshmend	PROPN
admet-2042	204	7	,	,	PUNCT
admet-2042	204	8	d.w	d.w	PROPN
admet-2042	204	9	.	.	PROPN
admet-2042	204	10	warnock	warnock	PROPN
admet-2042	204	11	.	.	PUNCT
admet-2042	205	1	clinical	clinical	ADJ
admet-2042	205	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	205	3	of	of	ADP
admet-2042	205	4	ketoconazole	ketoconazole	NOUN
admet-2042	205	5	.	.	PUNCT
admet-2042	206	1	clinical	clinical	ADJ
admet-2042	206	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	206	3	14	14	NUM
admet-2042	206	4	(	(	PUNCT
admet-2042	206	5	1988	1988	NUM
admet-2042	206	6	)	)	PUNCT
admet-2042	206	7	13	13	NUM
admet-2042	206	8	-	-	SYM
admet-2042	206	9	34	34	NUM
admet-2042	206	10	.	.	PUNCT
admet-2042	206	11	https://doi.org/10.2165/00003088-198814010-00002	https://doi.org/10.2165/00003088-198814010-00002	NOUN
admet-2042	206	12	.	.	PUNCT
admet-2042	207	1	[	[	X
admet-2042	207	2	14	14	NUM
admet-2042	207	3	]	]	PUNCT
admet-2042	207	4	b.	b.	PROPN
admet-2042	207	5	kukanich	kukanich	PROPN
admet-2042	207	6	,	,	PUNCT
admet-2042	207	7	m.	m.	NOUN
admet-2042	207	8	hubin	hubin	PROPN
admet-2042	207	9	.	.	PUNCT
admet-2042	208	1	the	the	DET
admet-2042	208	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	208	3	of	of	ADP
admet-2042	208	4	ketoconazole	ketoconazole	NOUN
admet-2042	208	5	and	and	CCONJ
admet-2042	208	6	its	its	PRON
admet-2042	208	7	effects	effect	NOUN
admet-2042	208	8	on	on	ADP
admet-2042	208	9	the	the	DET
admet-2042	208	10	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	208	11	of	of	ADP
admet-2042	208	12	midazolam	midazolam	PROPN
admet-2042	208	13	and	and	CCONJ
admet-2042	208	14	fentanyl	fentanyl	NOUN
admet-2042	208	15	in	in	ADP
admet-2042	208	16	dogs	dog	NOUN
admet-2042	208	17	.	.	PUNCT
admet-2042	209	1	journal	journal	NOUN
admet-2042	209	2	of	of	ADP
admet-2042	209	3	veterinary	veterinary	ADJ
admet-2042	209	4	pharmacology	pharmacology	NOUN
admet-2042	209	5	and	and	CCONJ
admet-2042	209	6	therapeutics	therapeutic	NOUN
admet-2042	209	7	33	33	NUM
admet-2042	209	8	(	(	PUNCT
admet-2042	209	9	2010	2010	NUM
admet-2042	209	10	)	)	PUNCT
admet-2042	209	11	42	42	NUM
admet-2042	209	12	-	-	SYM
admet-2042	209	13	49	49	NUM
admet-2042	209	14	.	.	PUNCT
admet-2042	210	1	https://doi.org/10.1111/j.1365-2885.2009.01105.x	https://doi.org/10.1111/j.1365-2885.2009.01105.x	NOUN
admet-2042	210	2	.	.	PUNCT
admet-2042	211	1	[	[	X
admet-2042	211	2	15	15	NUM
admet-2042	211	3	]	]	X
admet-2042	211	4	t.n	t.n	PROPN
admet-2042	211	5	.	.	PROPN
admet-2042	211	6	tozer	tozer	PROPN
admet-2042	211	7	.	.	PUNCT
admet-2042	211	8	farmakokinetika	farmakokinetika	PROPN
admet-2042	211	9	dan	dan	PROPN
admet-2042	211	10	farmakodinamika	farmakodinamika	PROPN
admet-2042	211	11	:	:	PUNCT
admet-2042	211	12	dasar	dasar	VERB
admet-2042	211	13	kuantitatif	kuantitatif	PROPN
admet-2042	211	14	terapi	terapi	PROPN
admet-2042	211	15	obat	obat	PROPN
admet-2042	211	16	,	,	PUNCT
admet-2042	211	17	egc	egc	PROPN
admet-2042	211	18	,	,	PUNCT
admet-2042	211	19	jakarta	jakarta	PROPN
admet-2042	211	20	,	,	PUNCT
admet-2042	211	21	2011	2011	NUM
admet-2042	211	22	.	.	PUNCT
admet-2042	212	1	https://onesearch.id/record/ios3107.50575	https://onesearch.id/record/ios3107.50575	PROPN
admet-2042	212	2	(	(	PUNCT
admet-2042	212	3	in	in	ADP
admet-2042	212	4	indonesian	indonesian	ADJ
admet-2042	212	5	)	)	PUNCT
admet-2042	213	1	[	[	X
admet-2042	213	2	16	16	NUM
admet-2042	213	3	]	]	X
admet-2042	213	4	r.	r.	PROPN
admet-2042	213	5	cristofoletti	cristofoletti	PROPN
admet-2042	213	6	,	,	PUNCT
admet-2042	213	7	n.	n.	PROPN
admet-2042	213	8	patel	patel	PROPN
admet-2042	213	9	,	,	PUNCT
admet-2042	213	10	j.b	j.b	PROPN
admet-2042	213	11	.	.	PROPN
admet-2042	213	12	dressman	dressman	PROPN
admet-2042	213	13	.	.	PUNCT
admet-2042	213	14	assessment	assessment	NOUN
admet-2042	213	15	of	of	ADP
admet-2042	213	16	bioequivalence	bioequivalence	NOUN
admet-2042	213	17	of	of	ADP
admet-2042	213	18	weak	weak	ADJ
admet-2042	213	19	base	base	NOUN
admet-2042	213	20	formulations	formulation	NOUN
admet-2042	213	21	under	under	ADP
admet-2042	213	22	various	various	ADJ
admet-2042	213	23	dosing	dose	VERB
admet-2042	213	24	conditions	condition	NOUN
admet-2042	213	25	using	use	VERB
admet-2042	213	26	physiologically	physiologically	ADV
admet-2042	213	27	based	base	VERB
admet-2042	213	28	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	213	29	simulations	simulation	NOUN
admet-2042	213	30	in	in	ADP
admet-2042	213	31	virtual	virtual	ADJ
admet-2042	213	32	populations	population	NOUN
admet-2042	213	33	.	.	PUNCT
admet-2042	214	1	case	case	NOUN
admet-2042	214	2	examples	example	NOUN
admet-2042	214	3	:	:	PUNCT
admet-2042	214	4	ketoconazole	ketoconazole	NOUN
admet-2042	214	5	and	and	CCONJ
admet-2042	214	6	posaconazole	posaconazole	NOUN
admet-2042	214	7	.	.	PUNCT
admet-2042	215	1	journal	journal	NOUN
admet-2042	215	2	of	of	ADP
admet-2042	215	3	pharmaceutical	pharmaceutical	PROPN
admet-2042	215	4	sciences	science	NOUN
admet-2042	215	5	106	106	NUM
admet-2042	215	6	(	(	PUNCT
admet-2042	215	7	2017	2017	NUM
admet-2042	215	8	)	)	PUNCT
admet-2042	215	9	560	560	NUM
admet-2042	215	10	-	-	SYM
admet-2042	215	11	569	569	NUM
admet-2042	215	12	.	.	PUNCT
admet-2042	216	1	https://doi.org/10.1016/j.xphs.2016.10.008	https://doi.org/10.1016/j.xphs.2016.10.008	NOUN
admet-2042	216	2	.	.	PUNCT
admet-2042	217	1	[	[	X
admet-2042	217	2	17	17	NUM
admet-2042	217	3	]	]	X
admet-2042	217	4	p.h	p.h	PROPN
admet-2042	217	5	.	.	PROPN
admet-2042	217	6	marathe	marathe	PROPN
admet-2042	217	7	.	.	PUNCT
admet-2042	217	8	pharmacokinetic	pharmacokinetic	ADJ
admet-2042	217	9	considerations	consideration	NOUN
admet-2042	217	10	in	in	ADP
admet-2042	217	11	drug	drug	NOUN
admet-2042	217	12	design	design	NOUN
admet-2042	217	13	and	and	CCONJ
admet-2042	217	14	development	development	NOUN
admet-2042	217	15	.	.	PUNCT
admet-2042	218	1	in	in	ADP
admet-2042	218	2	:	:	PUNCT
admet-2042	218	3	acs	acs	PROPN
admet-2042	218	4	webinar	webinar	NOUN
admet-2042	218	5	,	,	PUNCT
admet-2042	218	6	acs	acs	PROPN
admet-2042	218	7	chemistry	chemistry	NOUN
admet-2042	218	8	for	for	ADP
admet-2042	218	9	life	life	NOUN
admet-2042	218	10	,	,	PUNCT
admet-2042	218	11	washington	washington	PROPN
admet-2042	218	12	dc	dc	PROPN
admet-2042	218	13	,	,	PUNCT
admet-2042	218	14	2015	2015	NUM
admet-2042	218	15	.	.	PUNCT
admet-2042	219	1	https://www.acs.org/content/dam/acsorg/events/drugdiscovery/slides/2015-10-29-ddds10-pharmacokinetics.pdf	https://www.acs.org/content/dam/acsorg/events/drugdiscovery/slides/2015-10-29-ddds10-pharmacokinetics.pdf	PROPN
admet-2042	219	2	.	.	PUNCT
admet-2042	220	1	[	[	X
admet-2042	220	2	18	18	NUM
admet-2042	220	3	]	]	X
admet-2042	220	4	h.r	h.r	PROPN
admet-2042	220	5	.	.	PROPN
admet-2042	220	6	sadeghnia	sadeghnia	PROPN
admet-2042	220	7	,	,	PUNCT
admet-2042	220	8	m.	m.	NOUN
admet-2042	220	9	hassanzadeh	hassanzadeh	NOUN
admet-2042	220	10	-	-	PUNCT
admet-2042	220	11	khayyat	khayyat	PROPN
admet-2042	220	12	.	.	PUNCT
admet-2042	221	1	bioequivalency	bioequivalency	PROPN
admet-2042	221	2	study	study	NOUN
admet-2042	221	3	of	of	ADP
admet-2042	221	4	two	two	NUM
admet-2042	221	5	formulations	formulation	NOUN
admet-2042	221	6	of	of	ADP
admet-2042	221	7	ketoconazole	ketoconazole	PROPN
admet-2042	221	8	tablet	tablet	NOUN
admet-2042	221	9	in	in	ADP
admet-2042	221	10	healthy	healthy	ADJ
admet-2042	221	11	volunteers	volunteer	NOUN
admet-2042	221	12	.	.	PUNCT
admet-2042	222	1	iranian	iranian	ADJ
admet-2042	222	2	journal	journal	PROPN
admet-2042	222	3	of	of	ADP
admet-2042	222	4	pharmaceutical	pharmaceutical	PROPN
admet-2042	222	5	sciences	sciences	PROPN
admet-2042	222	6	autumn	autumn	NOUN
admet-2042	222	7	1	1	NUM
admet-2042	222	8	(	(	PUNCT
admet-2042	222	9	2005	2005	NUM
admet-2042	222	10	)	)	PUNCT
admet-2042	222	11	209	209	NUM
admet-2042	222	12	-	-	SYM
admet-2042	222	13	215	215	NUM
admet-2042	222	14	.	.	PUNCT
admet-2042	223	1	https://www.ijps.ir/article_1914.html	https://www.ijps.ir/article_1914.html	X
admet-2042	223	2	.	.	PUNCT
admet-2042	224	1	[	[	X
admet-2042	224	2	19	19	NUM
admet-2042	224	3	]	]	X
admet-2042	224	4	j.g	j.g	PROPN
admet-2042	224	5	.	.	PROPN
admet-2042	224	6	baxter	baxter	PROPN
admet-2042	224	7	,	,	PUNCT
admet-2042	224	8	c.	c.	PROPN
admet-2042	224	9	brass	brass	PROPN
admet-2042	224	10	,	,	PUNCT
admet-2042	224	11	j.j	j.j	PROPN
admet-2042	224	12	.	.	PROPN
admet-2042	224	13	schentag	schentag	ADJ
admet-2042	224	14	,	,	PUNCT
admet-2042	224	15	r.l	r.l	PROPN
admet-2042	224	16	.	.	PROPN
admet-2042	224	17	slaughter	slaughter	PROPN
admet-2042	224	18	.	.	PUNCT
admet-2042	225	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	225	2	of	of	ADP
admet-2042	225	3	ketoconazole	ketoconazole	NOUN
admet-2042	225	4	administered	administer	VERB
admet-2042	225	5	intravenously	intravenously	ADV
admet-2042	225	6	to	to	ADP
admet-2042	225	7	dogs	dog	NOUN
admet-2042	225	8	and	and	CCONJ
admet-2042	225	9	orally	orally	ADV
admet-2042	225	10	as	as	ADP
admet-2042	225	11	tablet	tablet	NOUN
admet-2042	225	12	and	and	CCONJ
admet-2042	225	13	solution	solution	NOUN
admet-2042	225	14	to	to	ADP
admet-2042	225	15	humans	human	NOUN
admet-2042	225	16	and	and	CCONJ
admet-2042	225	17	dogs	dog	NOUN
admet-2042	225	18	.	.	PUNCT
admet-2042	226	1	journal	journal	NOUN
admet-2042	226	2	of	of	ADP
admet-2042	226	3	pharmaceutical	pharmaceutical	NOUN
admet-2042	226	4	sciences	science	NOUN
admet-2042	226	5	75	75	NUM
admet-2042	226	6	(	(	PUNCT
admet-2042	226	7	1986	1986	NUM
admet-2042	226	8	)	)	PUNCT
admet-2042	226	9	443	443	NUM
admet-2042	226	10	-	-	SYM
admet-2042	226	11	447	447	NUM
admet-2042	226	12	.	.	PUNCT
admet-2042	227	1	https://doi.org/10.1002/jps.2600750504	https://doi.org/10.1002/jps.2600750504	PROPN
admet-2042	227	2	.	.	PUNCT
admet-2042	228	1	[	[	X
admet-2042	228	2	20	20	NUM
admet-2042	228	3	]	]	X
admet-2042	228	4	j.h	j.h	PROPN
admet-2042	228	5	.	.	PROPN
admet-2042	228	6	van	van	PROPN
admet-2042	228	7	tyle	tyle	PROPN
admet-2042	228	8	.	.	PUNCT
admet-2042	228	9	ketoconazole	ketoconazole	PROPN
admet-2042	228	10	.	.	PUNCT
admet-2042	229	1	mechanism	mechanism	NOUN
admet-2042	229	2	of	of	ADP
admet-2042	229	3	action	action	NOUN
admet-2042	229	4	,	,	PUNCT
admet-2042	229	5	spectrum	spectrum	NOUN
admet-2042	229	6	of	of	ADP
admet-2042	229	7	activity	activity	NOUN
admet-2042	229	8	,	,	PUNCT
admet-2042	229	9	pharmacokinetics	pharmacokinetic	NOUN
admet-2042	229	10	,	,	PUNCT
admet-2042	229	11	drug	drug	NOUN
admet-2042	229	12	interactions	interaction	NOUN
admet-2042	229	13	,	,	PUNCT
admet-2042	229	14	adverse	adverse	ADJ
admet-2042	229	15	reactions	reaction	NOUN
admet-2042	229	16	and	and	CCONJ
admet-2042	229	17	therapeutic	therapeutic	ADJ
admet-2042	229	18	use	use	NOUN
admet-2042	229	19	.	.	PUNCT
admet-2042	230	1	pharmacotherapy	pharmacotherapy	NOUN
admet-2042	230	2	4	4	NUM
admet-2042	230	3	(	(	PUNCT
admet-2042	230	4	1984	1984	NUM
admet-2042	230	5	)	)	PUNCT
admet-2042	230	6	343	343	NUM
admet-2042	230	7	-	-	SYM
admet-2042	230	8	373	373	NUM
admet-2042	230	9	.	.	PUNCT
admet-2042	231	1	https://doi.org/10.1002/j.1875-9114.1984.tb03398.x	https://doi.org/10.1002/j.1875-9114.1984.tb03398.x	PROPN
admet-2042	231	2	.	.	PUNCT
admet-2042	232	1	©	©	PROPN
admet-2042	232	2	2023	2023	NUM
admet-2042	232	3	by	by	ADP
admet-2042	232	4	the	the	DET
admet-2042	232	5	authors	author	NOUN
admet-2042	232	6	;	;	PUNCT
admet-2042	232	7	licensee	licensee	PROPN
admet-2042	232	8	iapc	iapc	PROPN
admet-2042	232	9	,	,	PUNCT
admet-2042	232	10	zagreb	zagreb	PROPN
admet-2042	232	11	,	,	PUNCT
admet-2042	232	12	croatia	croatia	PROPN
admet-2042	232	13	.	.	PUNCT
admet-2042	233	1	this	this	DET
admet-2042	233	2	article	article	NOUN
admet-2042	233	3	is	be	AUX
admet-2042	233	4	an	an	DET
admet-2042	233	5	open	open	ADJ
admet-2042	233	6	-	-	PUNCT
admet-2042	233	7	access	access	NOUN
admet-2042	233	8	article	article	NOUN
admet-2042	233	9	distributed	distribute	VERB
admet-2042	233	10	under	under	ADP
admet-2042	233	11	the	the	DET
admet-2042	233	12	terms	term	NOUN
admet-2042	233	13	and	and	CCONJ
admet-2042	233	14	conditions	condition	NOUN
admet-2042	233	15	of	of	ADP
admet-2042	233	16	the	the	DET
admet-2042	233	17	creative	creative	ADJ
admet-2042	233	18	commons	common	NOUN
admet-2042	233	19	attribution	attribution	NOUN
admet-2042	233	20	license	license	NOUN
admet-2042	233	21	(	(	PUNCT
admet-2042	233	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2042	233	23	)	)	PUNCT
admet-2042	233	24	https://doi.org/10.5599/admet.2042	https://doi.org/10.5599/admet.2042	NOUN
admet-2042	233	25	https://doi.org/10.31351/vol31iss2pp150-159	https://doi.org/10.31351/vol31iss2pp150-159	NOUN
admet-2042	233	26	https://doi.org/10.55262/fabadeczacilik.1259636	https://doi.org/10.55262/fabadeczacilik.1259636	NOUN
admet-2042	233	27	https://doi.org/10.1128/aac.30.2.206	https://doi.org/10.1128/aac.30.2.206	AUX
admet-2042	233	28	https://doi.org/10.2165/00003088-198814010-00002	https://doi.org/10.2165/00003088-198814010-00002	NOUN
admet-2042	233	29	https://doi.org/10.1111/j.1365-2885.2009.01105.x	https://doi.org/10.1111/j.1365-2885.2009.01105.x	VERB
admet-2042	233	30	https://onesearch.id/record/ios3107.50575	https://onesearch.id/record/ios3107.50575	PROPN
admet-2042	233	31	https://doi.org/10.1016/j.xphs.2016.10.008	https://doi.org/10.1016/j.xphs.2016.10.008	PROPN
admet-2042	233	32	https://www.acs.org/content/dam/acsorg/events/drug-discovery/slides/2015-10-29-ddds10-pharmacokinetics.pdf	https://www.acs.org/content/dam/acsorg/events/drug-discovery/slides/2015-10-29-ddds10-pharmacokinetics.pdf	PROPN
admet-2042	233	33	https://www.acs.org/content/dam/acsorg/events/drug-discovery/slides/2015-10-29-ddds10-pharmacokinetics.pdf	https://www.acs.org/content/dam/acsorg/events/drug-discovery/slides/2015-10-29-ddds10-pharmacokinetics.pdf	PROPN
admet-2042	233	34	https://www.ijps.ir/article_1914.html	https://www.ijps.ir/article_1914.html	PROPN
admet-2042	233	35	https://doi.org/10.1002/jps.2600750504	https://doi.org/10.1002/jps.2600750504	PROPN
admet-2042	233	36	https://doi.org/10.1002/j.1875-9114.1984.tb03398.x	https://doi.org/10.1002/j.1875-9114.1984.tb03398.x	PROPN
admet-2042	233	37	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN