id	sid	tid	token	lemma	pos
admet-2043	1	1	doi	doi	PROPN
admet-2043	1	2	:	:	PUNCT
admet-2043	1	3	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1	4	63	63	NUM
admet-2043	1	5	admet	admet	X
admet-2043	1	6	&	&	CCONJ
admet-2043	1	7	dmpk	dmpk	PROPN
admet-2043	1	8	12(1	12(1	PROPN
admet-2043	1	9	)	)	PUNCT
admet-2043	1	10	(	(	PUNCT
admet-2043	1	11	2024	2024	NUM
admet-2043	1	12	)	)	PUNCT
admet-2043	1	13	63	63	NUM
admet-2043	1	14	-	-	SYM
admet-2043	1	15	105	105	NUM
admet-2043	1	16	;	;	PUNCT
admet-2043	1	17	doi	doi	NOUN
admet-2043	1	18	:	:	PUNCT
admet-2043	1	19	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1	20	open	open	ADJ
admet-2043	1	21	access	access	NOUN
admet-2043	1	22	:	:	PUNCT
admet-2043	1	23	issn	issn	PROPN
admet-2043	1	24	:	:	PUNCT
admet-2043	1	25	1848	1848	NUM
admet-2043	1	26	-	-	SYM
admet-2043	1	27	7718	7718	NUM
admet-2043	1	28	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2043	1	29	review	review	NOUN
admet-2043	1	30	nanomaterials	nanomaterial	NOUN
admet-2043	1	31	as	as	ADP
admet-2043	1	32	drug	drug	NOUN
admet-2043	1	33	delivery	delivery	NOUN
admet-2043	1	34	agents	agent	NOUN
admet-2043	1	35	for	for	ADP
admet-2043	1	36	overcoming	overcome	VERB
admet-2043	1	37	the	the	DET
admet-2043	1	38	blood	blood	NOUN
admet-2043	1	39	-	-	PUNCT
admet-2043	1	40	brain	brain	NOUN
admet-2043	1	41	barrier	barrier	NOUN
admet-2043	1	42	:	:	PUNCT
admet-2043	1	43	a	a	DET
admet-2043	1	44	comprehensive	comprehensive	ADJ
admet-2043	1	45	review	review	NOUN
admet-2043	1	46	mangesh	mangesh	ADJ
admet-2043	1	47	kulkarni1	kulkarni1	PROPN
admet-2043	1	48	,	,	PUNCT
admet-2043	1	49	krishi	krishi	PROPN
admet-2043	1	50	patel2	patel2	PROPN
admet-2043	1	51	,	,	PUNCT
admet-2043	1	52	ayush	ayush	PROPN
admet-2043	1	53	patel2	patel2	PROPN
admet-2043	1	54	,	,	PUNCT
admet-2043	1	55	swayamprakash	swayamprakash	NOUN
admet-2043	1	56	patel2	patel2	PROPN
admet-2043	1	57	,	,	PUNCT
admet-2043	1	58	*	*	PUNCT
admet-2043	1	59	,	,	PUNCT
admet-2043	1	60	jagruti	jagruti	PROPN
admet-2043	1	61	desai2	desai2	PROPN
admet-2043	1	62	,	,	PUNCT
admet-2043	1	63	mehul	mehul	PROPN
admet-2043	1	64	patel2	patel2	PROPN
admet-2043	1	65	,	,	PUNCT
admet-2043	1	66	umang	umang	PROPN
admet-2043	1	67	shah2	shah2	PROPN
admet-2043	1	68	,	,	PUNCT
admet-2043	1	69	ashish	ashish	ADJ
admet-2043	1	70	patel2	patel2	NOUN
admet-2043	1	71	and	and	CCONJ
admet-2043	1	72	nilay	nilay	VERB
admet-2043	1	73	solanki2	solanki2	PROPN
admet-2043	1	74	1department	1department	NUM
admet-2043	1	75	of	of	ADP
admet-2043	1	76	pharmaceutical	pharmaceutical	ADJ
admet-2043	1	77	technology	technology	NOUN
admet-2043	1	78	;	;	PUNCT
admet-2043	1	79	l	l	PROPN
admet-2043	1	80	j	j	PROPN
admet-2043	1	81	institute	institute	PROPN
admet-2043	1	82	of	of	ADP
admet-2043	1	83	pharmacy	pharmacy	NOUN
admet-2043	1	84	;	;	PUNCT
admet-2043	1	85	l	l	PROPN
admet-2043	1	86	j	j	PROPN
admet-2043	1	87	university	university	PROPN
admet-2043	1	88	;	;	PUNCT
admet-2043	1	89	opp	opp	PROPN
admet-2043	1	90	.	.	PUNCT
admet-2043	1	91	kataria	kataria	PROPN
admet-2043	1	92	motors	motors	PROPN
admet-2043	1	93	;	;	PUNCT
admet-2043	1	94	sarkhejgandhinagar	sarkhejgandhinagar	NOUN
admet-2043	1	95	highway-382210	highway-382210	NOUN
admet-2043	1	96	,	,	PUNCT
admet-2043	1	97	india	india	PROPN
admet-2043	1	98	2department	2department	PROPN
admet-2043	1	99	of	of	ADP
admet-2043	1	100	pharmaceutics	pharmaceutic	NOUN
admet-2043	1	101	,	,	PUNCT
admet-2043	1	102	ramanbhai	ramanbhai	PROPN
admet-2043	1	103	patel	patel	PROPN
admet-2043	1	104	college	college	PROPN
admet-2043	1	105	of	of	ADP
admet-2043	1	106	pharmacy	pharmacy	PROPN
admet-2043	1	107	,	,	PUNCT
admet-2043	1	108	charotar	charotar	PROPN
admet-2043	1	109	university	university	PROPN
admet-2043	1	110	of	of	ADP
admet-2043	1	111	science	science	NOUN
admet-2043	1	112	and	and	CCONJ
admet-2043	1	113	technology	technology	NOUN
admet-2043	1	114	(	(	PUNCT
admet-2043	1	115	charusat	charusat	VERB
admet-2043	1	116	)	)	PUNCT
admet-2043	1	117	,	,	PUNCT
admet-2043	1	118	charusat	charusat	VERB
admet-2043	1	119	campus	campus	NOUN
admet-2043	1	120	,	,	PUNCT
admet-2043	1	121	changa	changa	PROPN
admet-2043	1	122	388421	388421	NUM
admet-2043	1	123	,	,	PUNCT
admet-2043	1	124	india	india	PROPN
admet-2043	1	125	*	*	PUNCT
admet-2043	1	126	corresponding	correspond	VERB
admet-2043	1	127	author	author	NOUN
admet-2043	1	128	:	:	PUNCT
admet-2043	1	129	e	e	NOUN
admet-2043	1	130	-	-	NOUN
admet-2043	1	131	mail	mail	NOUN
admet-2043	1	132	:	:	PUNCT
admet-2043	1	133	swayamprakash.patel@gmail.com	swayamprakash.patel@gmail.com	X
admet-2043	1	134	received	receive	VERB
admet-2043	1	135	:	:	PUNCT
admet-2043	1	136	august	august	PROPN
admet-2043	1	137	21	21	NUM
admet-2043	1	138	,	,	PUNCT
admet-2043	1	139	2023	2023	NUM
admet-2043	1	140	;	;	PUNCT
admet-2043	1	141	revised	revise	VERB
admet-2043	1	142	:	:	PUNCT
admet-2043	1	143	october	october	PROPN
admet-2043	1	144	23	23	NUM
admet-2043	1	145	,	,	PUNCT
admet-2043	1	146	2023	2023	NUM
admet-2043	1	147	;	;	PUNCT
admet-2043	1	148	published	publish	VERB
admet-2043	1	149	:	:	PUNCT
admet-2043	1	150	october	october	PROPN
admet-2043	1	151	31	31	NUM
admet-2043	1	152	,	,	PUNCT
admet-2043	1	153	2023	2023	NUM
admet-2043	1	154	abstract	abstract	ADJ
admet-2043	1	155	background	background	NOUN
admet-2043	1	156	and	and	CCONJ
admet-2043	1	157	purpose	purpose	NOUN
admet-2043	1	158	:	:	PUNCT
admet-2043	1	159	the	the	DET
admet-2043	1	160	blood	blood	NOUN
admet-2043	1	161	-	-	PUNCT
admet-2043	1	162	brain	brain	NOUN
admet-2043	1	163	barrier	barrier	NOUN
admet-2043	1	164	(	(	PUNCT
admet-2043	1	165	bbb	bbb	PROPN
admet-2043	1	166	)	)	PUNCT
admet-2043	1	167	,	,	PUNCT
admet-2043	1	168	a	a	DET
admet-2043	1	169	critical	critical	ADJ
admet-2043	1	170	interface	interface	NOUN
admet-2043	1	171	of	of	ADP
admet-2043	1	172	specialized	specialized	ADJ
admet-2043	1	173	endothelial	endothelial	ADJ
admet-2043	1	174	cells	cell	NOUN
admet-2043	1	175	,	,	PUNCT
admet-2043	1	176	plays	play	VERB
admet-2043	1	177	a	a	DET
admet-2043	1	178	pivotal	pivotal	ADJ
admet-2043	1	179	role	role	NOUN
admet-2043	1	180	in	in	ADP
admet-2043	1	181	regulating	regulate	VERB
admet-2043	1	182	molecular	molecular	ADJ
admet-2043	1	183	and	and	CCONJ
admet-2043	1	184	ion	ion	NOUN
admet-2043	1	185	transport	transport	NOUN
admet-2043	1	186	between	between	ADP
admet-2043	1	187	the	the	DET
admet-2043	1	188	central	central	ADJ
admet-2043	1	189	nervous	nervous	ADJ
admet-2043	1	190	system	system	NOUN
admet-2043	1	191	(	(	PUNCT
admet-2043	1	192	cns	cns	NOUN
admet-2043	1	193	)	)	PUNCT
admet-2043	1	194	and	and	CCONJ
admet-2043	1	195	systemic	systemic	ADJ
admet-2043	1	196	circulation	circulation	NOUN
admet-2043	1	197	.	.	PUNCT
admet-2043	2	1	experimental	experimental	ADJ
admet-2043	2	2	approach	approach	NOUN
admet-2043	2	3	:	:	PUNCT
admet-2043	2	4	this	this	DET
admet-2043	2	5	review	review	NOUN
admet-2043	2	6	aims	aim	VERB
admet-2043	2	7	to	to	PART
admet-2043	2	8	delve	delve	VERB
admet-2043	2	9	into	into	ADP
admet-2043	2	10	the	the	DET
admet-2043	2	11	intricate	intricate	ADJ
admet-2043	2	12	architecture	architecture	NOUN
admet-2043	2	13	and	and	CCONJ
admet-2043	2	14	functions	function	NOUN
admet-2043	2	15	of	of	ADP
admet-2043	2	16	the	the	DET
admet-2043	2	17	bbb	bbb	NOUN
admet-2043	2	18	while	while	SCONJ
admet-2043	2	19	addressing	address	VERB
admet-2043	2	20	challenges	challenge	NOUN
admet-2043	2	21	associated	associate	VERB
admet-2043	2	22	with	with	ADP
admet-2043	2	23	delivering	deliver	VERB
admet-2043	2	24	therapeutics	therapeutic	NOUN
admet-2043	2	25	to	to	ADP
admet-2043	2	26	the	the	DET
admet-2043	2	27	brain	brain	NOUN
admet-2043	2	28	.	.	PUNCT
admet-2043	3	1	historical	historical	ADJ
admet-2043	3	2	milestones	milestone	NOUN
admet-2043	3	3	and	and	CCONJ
admet-2043	3	4	contemporary	contemporary	ADJ
admet-2043	3	5	insights	insight	NOUN
admet-2043	3	6	underscore	underscore	VERB
admet-2043	3	7	the	the	DET
admet-2043	3	8	bbb	bbb	NOUN
admet-2043	3	9	's	's	PART
admet-2043	3	10	significance	significance	NOUN
admet-2043	3	11	in	in	ADP
admet-2043	3	12	protecting	protect	VERB
admet-2043	3	13	the	the	DET
admet-2043	3	14	cns	cns	NOUN
admet-2043	3	15	.	.	PUNCT
admet-2043	4	1	key	key	ADJ
admet-2043	4	2	results	result	NOUN
admet-2043	4	3	:	:	PUNCT
admet-2043	4	4	innovative	innovative	ADJ
admet-2043	4	5	approaches	approach	NOUN
admet-2043	4	6	for	for	ADP
admet-2043	4	7	enhanced	enhanced	ADJ
admet-2043	4	8	drug	drug	NOUN
admet-2043	4	9	transport	transport	NOUN
admet-2043	4	10	include	include	VERB
admet-2043	4	11	intranasal	intranasal	ADJ
admet-2043	4	12	delivery	delivery	NOUN
admet-2043	4	13	exploiting	exploit	VERB
admet-2043	4	14	olfactory	olfactory	ADJ
admet-2043	4	15	and	and	CCONJ
admet-2043	4	16	trigeminal	trigeminal	ADJ
admet-2043	4	17	pathways	pathway	NOUN
admet-2043	4	18	,	,	PUNCT
admet-2043	4	19	as	as	ADV
admet-2043	4	20	well	well	ADV
admet-2043	4	21	as	as	ADP
admet-2043	4	22	techniques	technique	NOUN
admet-2043	4	23	like	like	ADP
admet-2043	4	24	temporary	temporary	ADJ
admet-2043	4	25	bbb	bbb	NOUN
admet-2043	4	26	opening	opening	NOUN
admet-2043	4	27	through	through	ADP
admet-2043	4	28	chemicals	chemical	NOUN
admet-2043	4	29	,	,	PUNCT
admet-2043	4	30	receptors	receptor	NOUN
admet-2043	4	31	,	,	PUNCT
admet-2043	4	32	or	or	CCONJ
admet-2043	4	33	focused	focus	VERB
admet-2043	4	34	ultrasound	ultrasound	NOUN
admet-2043	4	35	.	.	PUNCT
admet-2043	5	1	these	these	DET
admet-2043	5	2	avenues	avenue	NOUN
admet-2043	5	3	hold	hold	VERB
admet-2043	5	4	the	the	DET
admet-2043	5	5	potential	potential	NOUN
admet-2043	5	6	to	to	PART
admet-2043	5	7	reshape	reshape	VERB
admet-2043	5	8	conventional	conventional	ADJ
admet-2043	5	9	drug	drug	NOUN
admet-2043	5	10	delivery	delivery	NOUN
admet-2043	5	11	paradigms	paradigm	VERB
admet-2043	5	12	and	and	CCONJ
admet-2043	5	13	address	address	VERB
admet-2043	5	14	the	the	DET
admet-2043	5	15	limitations	limitation	NOUN
admet-2043	5	16	posed	pose	VERB
admet-2043	5	17	by	by	ADP
admet-2043	5	18	the	the	DET
admet-2043	5	19	bbb	bbb	PROPN
admet-2043	5	20	's	's	PART
admet-2043	5	21	selectivity	selectivity	NOUN
admet-2043	5	22	.	.	PUNCT
admet-2043	6	1	conclusion	conclusion	NOUN
admet-2043	6	2	:	:	PUNCT
admet-2043	6	3	this	this	DET
admet-2043	6	4	review	review	NOUN
admet-2043	6	5	underscores	underscore	VERB
admet-2043	6	6	the	the	DET
admet-2043	6	7	vital	vital	ADJ
admet-2043	6	8	role	role	NOUN
admet-2043	6	9	of	of	ADP
admet-2043	6	10	the	the	DET
admet-2043	6	11	bbb	bbb	NOUN
admet-2043	6	12	in	in	ADP
admet-2043	6	13	maintaining	maintain	VERB
admet-2043	6	14	cns	cns	NOUN
admet-2043	6	15	health	health	NOUN
admet-2043	6	16	and	and	CCONJ
admet-2043	6	17	emphasizes	emphasize	VERB
admet-2043	6	18	the	the	DET
admet-2043	6	19	importance	importance	NOUN
admet-2043	6	20	of	of	ADP
admet-2043	6	21	effective	effective	ADJ
admet-2043	6	22	drug	drug	NOUN
admet-2043	6	23	delivery	delivery	NOUN
admet-2043	6	24	through	through	ADP
admet-2043	6	25	this	this	DET
admet-2043	6	26	barrier	barrier	NOUN
admet-2043	6	27	.	.	PUNCT
admet-2043	7	1	nanoparticles	nanoparticle	NOUN
admet-2043	7	2	emerge	emerge	VERB
admet-2043	7	3	as	as	ADP
admet-2043	7	4	promising	promise	VERB
admet-2043	7	5	candidates	candidate	NOUN
admet-2043	7	6	to	to	PART
admet-2043	7	7	overcome	overcome	VERB
admet-2043	7	8	bbb	bbb	NOUN
admet-2043	7	9	limitations	limitation	NOUN
admet-2043	7	10	and	and	CCONJ
admet-2043	7	11	potentially	potentially	ADV
admet-2043	7	12	revolutionize	revolutionize	VERB
admet-2043	7	13	the	the	DET
admet-2043	7	14	treatment	treatment	NOUN
admet-2043	7	15	of	of	ADP
admet-2043	7	16	cns	cns	NOUN
admet-2043	7	17	disorders	disorder	NOUN
admet-2043	7	18	.	.	PUNCT
admet-2043	8	1	as	as	SCONJ
admet-2043	8	2	research	research	NOUN
admet-2043	8	3	progresses	progress	NOUN
admet-2043	8	4	,	,	PUNCT
admet-2043	8	5	the	the	DET
admet-2043	8	6	application	application	NOUN
admet-2043	8	7	of	of	ADP
admet-2043	8	8	nanomaterials	nanomaterial	NOUN
admet-2043	8	9	shows	show	VERB
admet-2043	8	10	immense	immense	ADJ
admet-2043	8	11	potential	potential	NOUN
admet-2043	8	12	for	for	ADP
admet-2043	8	13	advancing	advance	VERB
admet-2043	8	14	neurological	neurological	ADJ
admet-2043	8	15	therapeutics	therapeutic	NOUN
admet-2043	8	16	,	,	PUNCT
admet-2043	8	17	albeit	albeit	SCONJ
admet-2043	8	18	with	with	ADP
admet-2043	8	19	careful	careful	ADJ
admet-2043	8	20	consideration	consideration	NOUN
admet-2043	8	21	of	of	ADP
admet-2043	8	22	safety	safety	NOUN
admet-2043	8	23	aspects	aspect	NOUN
admet-2043	8	24	.	.	PUNCT
admet-2043	9	1	©	©	NOUN
admet-2043	9	2	2023	2023	NUM
admet-2043	9	3	by	by	ADP
admet-2043	9	4	the	the	DET
admet-2043	9	5	authors	author	NOUN
admet-2043	9	6	.	.	PUNCT
admet-2043	10	1	this	this	DET
admet-2043	10	2	article	article	NOUN
admet-2043	10	3	is	be	AUX
admet-2043	10	4	an	an	DET
admet-2043	10	5	open	open	ADJ
admet-2043	10	6	-	-	PUNCT
admet-2043	10	7	access	access	NOUN
admet-2043	10	8	article	article	NOUN
admet-2043	10	9	distributed	distribute	VERB
admet-2043	10	10	under	under	ADP
admet-2043	10	11	the	the	DET
admet-2043	10	12	terms	term	NOUN
admet-2043	10	13	and	and	CCONJ
admet-2043	10	14	conditions	condition	NOUN
admet-2043	10	15	of	of	ADP
admet-2043	10	16	the	the	DET
admet-2043	10	17	creative	creative	ADJ
admet-2043	10	18	commons	common	NOUN
admet-2043	10	19	attribution	attribution	NOUN
admet-2043	10	20	license	license	NOUN
admet-2043	10	21	(	(	PUNCT
admet-2043	10	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2043	10	23	)	)	PUNCT
admet-2043	10	24	.	.	PUNCT
admet-2043	11	1	keywords	keyword	VERB
admet-2043	11	2	cns	cns	NOUN
admet-2043	11	3	;	;	PUNCT
admet-2043	11	4	drug	drug	NOUN
admet-2043	11	5	delivery	delivery	NOUN
admet-2043	11	6	;	;	PUNCT
admet-2043	11	7	nanoparticle	nanoparticle	NOUN
admet-2043	11	8	;	;	PUNCT
admet-2043	11	9	liposomes	liposome	NOUN
admet-2043	11	10	;	;	PUNCT
admet-2043	11	11	dendrimer	dendrimer	NOUN
admet-2043	11	12	;	;	PUNCT
admet-2043	11	13	safety	safety	NOUN
admet-2043	11	14	and	and	CCONJ
admet-2043	11	15	regulation	regulation	NOUN
admet-2043	11	16	introduction	introduction	NOUN
admet-2043	11	17	to	to	ADP
admet-2043	11	18	blood	blood	NOUN
admet-2043	11	19	-	-	PUNCT
admet-2043	11	20	brain	brain	NOUN
admet-2043	11	21	barrier	barrier	NOUN
admet-2043	11	22	background	background	NOUN
admet-2043	11	23	of	of	ADP
admet-2043	11	24	blood	blood	NOUN
admet-2043	11	25	-	-	PUNCT
admet-2043	11	26	brain	brain	NOUN
admet-2043	11	27	barrier	barrier	NOUN
admet-2043	11	28	the	the	DET
admet-2043	11	29	blood	blood	NOUN
admet-2043	11	30	-	-	PUNCT
admet-2043	11	31	brain	brain	NOUN
admet-2043	11	32	barrier	barrier	NOUN
admet-2043	11	33	(	(	PUNCT
admet-2043	11	34	bbb	bbb	PROPN
admet-2043	11	35	)	)	PUNCT
admet-2043	11	36	,	,	PUNCT
admet-2043	11	37	formed	form	VERB
admet-2043	11	38	by	by	ADP
admet-2043	11	39	the	the	DET
admet-2043	11	40	endothelial	endothelial	ADJ
admet-2043	11	41	cells	cell	NOUN
admet-2043	11	42	that	that	PRON
admet-2043	11	43	line	line	VERB
admet-2043	11	44	cerebral	cerebral	ADJ
admet-2043	11	45	micro	micro	ADJ
admet-2043	11	46	vessels	vessel	NOUN
admet-2043	11	47	,	,	PUNCT
admet-2043	11	48	plays	play	VERB
admet-2043	11	49	a	a	DET
admet-2043	11	50	crucial	crucial	ADJ
admet-2043	11	51	part	part	NOUN
admet-2043	11	52	in	in	ADP
admet-2043	11	53	maintaining	maintain	VERB
admet-2043	11	54	a	a	DET
admet-2043	11	55	carefully	carefully	ADV
admet-2043	11	56	regulated	regulate	VERB
admet-2043	11	57	milieu	milieu	NOUN
admet-2043	11	58	for	for	ADP
admet-2043	11	59	dependable	dependable	ADJ
admet-2043	11	60	neuronal	neuronal	ADJ
admet-2043	11	61	signalling	signalling	NOUN
admet-2043	11	62	.	.	PUNCT
admet-2043	12	1	this	this	PRON
admet-2043	12	2	is	be	AUX
admet-2043	12	3	because	because	SCONJ
admet-2043	12	4	the	the	DET
admet-2043	12	5	bbb	bbb	PROPN
admet-2043	12	6	is	be	AUX
admet-2043	12	7	formed	form	VERB
admet-2043	12	8	by	by	ADP
admet-2043	12	9	the	the	DET
admet-2043	12	10	endothelial	endothelial	ADJ
admet-2043	12	11	cells	cell	NOUN
admet-2043	12	12	that	that	PRON
admet-2043	12	13	line	line	VERB
admet-2043	12	14	cerebral	cerebral	PROPN
admet-2043	12	15	micro	micro	PROPN
admet-2043	12	16	capillaries	capillary	NOUN
admet-2043	12	17	.	.	PUNCT
admet-2043	13	1	much	much	ADJ
admet-2043	13	2	research	research	NOUN
admet-2043	13	3	is	be	AUX
admet-2043	13	4	being	be	AUX
admet-2043	13	5	done	do	VERB
admet-2043	13	6	on	on	ADP
admet-2043	13	7	how	how	SCONJ
admet-2043	13	8	brain	brain	NOUN
admet-2043	13	9	micro	micro	ADJ
admet-2043	13	10	vessels	vessel	NOUN
admet-2043	13	11	,	,	PUNCT
admet-2043	13	12	astrocytes	astrocyte	NOUN
admet-2043	13	13	,	,	PUNCT
admet-2043	13	14	and	and	CCONJ
admet-2043	13	15	neurons	neuron	NOUN
admet-2043	13	16	can	can	AUX
admet-2043	13	17	work	work	VERB
admet-2043	13	18	together	together	ADV
admet-2043	13	19	to	to	PART
admet-2043	13	20	produce	produce	VERB
admet-2043	13	21	functional	functional	ADJ
admet-2043	13	22	neurovascular	neurovascular	ADJ
admet-2043	13	23	units	unit	NOUN
admet-2043	13	24	,	,	PUNCT
admet-2043	13	25	and	and	CCONJ
admet-2043	13	26	new	new	ADJ
admet-2043	13	27	studies	study	NOUN
admet-2043	13	28	have	have	AUX
admet-2043	13	29	shed	shed	VERB
admet-2043	13	30	light	light	NOUN
admet-2043	13	31	on	on	ADP
admet-2043	13	32	how	how	SCONJ
admet-2043	13	33	important	important	ADJ
admet-2043	13	34	brain	brain	NOUN
admet-2043	13	35	endothelial	endothelial	NOUN
admet-2043	13	36	cells	cell	NOUN
admet-2043	13	37	are	be	AUX
admet-2043	13	38	in	in	ADP
admet-2043	13	39	this	this	DET
admet-2043	13	40	modular	modular	ADJ
admet-2043	13	41	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	13	42	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	13	43	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2043	13	44	mailto:swayamprakash.patel@gmail.com	mailto:swayamprakash.patel@gmail.com	X
admet-2043	14	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2043	14	2	m.	m.	PROPN
admet-2043	14	3	kulkarni	kulkarni	PROPN
admet-2043	14	4	et	et	PROPN
admet-2043	14	5	al	al	PROPN
admet-2043	14	6	.	.	PROPN
admet-2043	14	7	admet	admet	PROPN
admet-2043	14	8	&	&	CCONJ
admet-2043	14	9	dmpk	dmpk	PROPN
admet-2043	14	10	12(1	12(1	PROPN
admet-2043	14	11	)	)	PUNCT
admet-2043	14	12	(	(	PUNCT
admet-2043	14	13	2024	2024	NUM
admet-2043	14	14	)	)	PUNCT
admet-2043	14	15	63	63	NUM
admet-2043	14	16	-	-	SYM
admet-2043	14	17	105	105	NUM
admet-2043	14	18	64	64	NUM
admet-2043	14	19	organisation	organisation	NOUN
admet-2043	14	20	.	.	PUNCT
admet-2043	15	1	the	the	DET
admet-2043	15	2	anatomical	anatomical	ADJ
admet-2043	15	3	representation	representation	NOUN
admet-2043	15	4	of	of	ADP
admet-2043	15	5	the	the	DET
admet-2043	15	6	blood	blood	NOUN
admet-2043	15	7	-	-	PUNCT
admet-2043	15	8	brain	brain	NOUN
admet-2043	15	9	barrier	barrier	NOUN
admet-2043	15	10	(	(	PUNCT
admet-2043	15	11	bbb	bbb	NOUN
admet-2043	15	12	)	)	PUNCT
admet-2043	15	13	is	be	AUX
admet-2043	15	14	shown	show	VERB
admet-2043	15	15	in	in	ADP
admet-2043	15	16	figure	figure	NOUN
admet-2043	15	17	1	1	NUM
admet-2043	15	18	,	,	PUNCT
admet-2043	15	19	where	where	SCONJ
admet-2043	15	20	various	various	ADJ
admet-2043	15	21	parts	part	NOUN
admet-2043	15	22	of	of	ADP
admet-2043	15	23	the	the	DET
admet-2043	15	24	bbb	bbb	PROPN
admet-2043	15	25	have	have	AUX
admet-2043	15	26	been	be	AUX
admet-2043	15	27	depicted	depict	VERB
admet-2043	15	28	.	.	PUNCT
admet-2043	16	1	the	the	DET
admet-2043	16	2	presence	presence	NOUN
admet-2043	16	3	of	of	ADP
admet-2043	16	4	bbb	bbb	PROPN
admet-2043	16	5	was	be	AUX
admet-2043	16	6	first	first	ADV
admet-2043	16	7	found	find	VERB
admet-2043	16	8	by	by	ADP
admet-2043	16	9	paul	paul	PROPN
admet-2043	16	10	ehrlich	ehrlich	PROPN
admet-2043	16	11	and	and	CCONJ
admet-2043	16	12	confirmed	confirm	VERB
admet-2043	16	13	by	by	ADP
admet-2043	16	14	edwin	edwin	PROPN
admet-2043	16	15	goldmann	goldmann	PROPN
admet-2043	16	16	.	.	PUNCT
admet-2043	17	1	bbb	bbb	PROPN
admet-2043	17	2	isolates	isolate	VERB
admet-2043	17	3	foreign	foreign	ADJ
admet-2043	17	4	particles	particle	NOUN
admet-2043	17	5	in	in	ADP
admet-2043	17	6	the	the	DET
admet-2043	17	7	blood	blood	NOUN
admet-2043	17	8	from	from	ADP
admet-2043	17	9	the	the	DET
admet-2043	17	10	central	central	ADJ
admet-2043	17	11	nervous	nervous	ADJ
admet-2043	17	12	system	system	NOUN
admet-2043	17	13	(	(	PUNCT
admet-2043	17	14	cns	cns	NOUN
admet-2043	17	15	)	)	PUNCT
admet-2043	17	16	and	and	CCONJ
admet-2043	17	17	thus	thus	ADV
admet-2043	17	18	plays	play	VERB
admet-2043	17	19	a	a	DET
admet-2043	17	20	crucial	crucial	ADJ
admet-2043	17	21	role	role	NOUN
admet-2043	17	22	in	in	ADP
admet-2043	17	23	the	the	DET
admet-2043	17	24	protection	protection	NOUN
admet-2043	17	25	of	of	ADP
admet-2043	17	26	the	the	DET
admet-2043	17	27	cns	cns	NOUN
admet-2043	18	1	[	[	X
admet-2043	18	2	1	1	NUM
admet-2043	18	3	]	]	PUNCT
admet-2043	18	4	.	.	PUNCT
admet-2043	19	1	the	the	DET
admet-2043	19	2	cns	cns	PROPN
admet-2043	19	3	is	be	AUX
admet-2043	19	4	composed	compose	VERB
admet-2043	19	5	of	of	ADP
admet-2043	19	6	two	two	NUM
admet-2043	19	7	vital	vital	ADJ
admet-2043	19	8	segments	segment	NOUN
admet-2043	19	9	of	of	ADP
admet-2043	19	10	the	the	DET
admet-2043	19	11	human	human	ADJ
admet-2043	19	12	body	body	NOUN
admet-2043	19	13	,	,	PUNCT
admet-2043	19	14	namely	namely	ADV
admet-2043	19	15	the	the	DET
admet-2043	19	16	human	human	ADJ
admet-2043	19	17	brain	brain	NOUN
admet-2043	19	18	and	and	CCONJ
admet-2043	19	19	the	the	DET
admet-2043	19	20	spinal	spinal	NOUN
admet-2043	19	21	cord	cord	NOUN
admet-2043	19	22	.	.	PUNCT
admet-2043	20	1	the	the	DET
admet-2043	20	2	bbb	bbb	PROPN
admet-2043	20	3	and	and	CCONJ
admet-2043	20	4	blood	blood	NOUN
admet-2043	20	5	-	-	PUNCT
admet-2043	20	6	cerebrospinal	cerebrospinal	ADJ
admet-2043	20	7	fluid	fluid	NOUN
admet-2043	20	8	barrier	barrier	NOUN
admet-2043	20	9	(	(	PUNCT
admet-2043	20	10	bcb	bcb	PROPN
admet-2043	20	11	)	)	PUNCT
admet-2043	20	12	cover	cover	VERB
admet-2043	20	13	these	these	DET
admet-2043	20	14	two	two	NUM
admet-2043	20	15	.	.	PUNCT
admet-2043	21	1	the	the	DET
admet-2043	21	2	bbb	bbb	PROPN
admet-2043	21	3	functions	function	NOUN
admet-2043	21	4	as	as	ADP
admet-2043	21	5	an	an	DET
admet-2043	21	6	extremely	extremely	ADV
admet-2043	21	7	selective	selective	ADJ
admet-2043	21	8	permeable	permeable	ADJ
admet-2043	21	9	barrier	barrier	NOUN
admet-2043	21	10	that	that	PRON
admet-2043	21	11	mediates	mediate	VERB
admet-2043	21	12	the	the	DET
admet-2043	21	13	transport	transport	NOUN
admet-2043	21	14	of	of	ADP
admet-2043	21	15	ions	ion	NOUN
admet-2043	21	16	and	and	CCONJ
admet-2043	21	17	molecules	molecule	NOUN
admet-2043	21	18	between	between	ADP
admet-2043	21	19	the	the	DET
admet-2043	21	20	systemic	systemic	ADJ
admet-2043	21	21	circulation	circulation	NOUN
admet-2043	21	22	and	and	CCONJ
admet-2043	21	23	the	the	DET
admet-2043	21	24	central	central	ADJ
admet-2043	21	25	nervous	nervous	ADJ
admet-2043	21	26	system	system	NOUN
admet-2043	21	27	[	[	X
admet-2043	21	28	2	2	NUM
admet-2043	21	29	]	]	PUNCT
admet-2043	21	30	.	.	PUNCT
admet-2043	22	1	the	the	DET
admet-2043	22	2	blood	blood	NOUN
admet-2043	22	3	-	-	PUNCT
admet-2043	22	4	brain	brain	NOUN
admet-2043	22	5	barrier	barrier	NOUN
admet-2043	22	6	comprises	comprise	VERB
admet-2043	22	7	two	two	NUM
admet-2043	22	8	distinct	distinct	ADJ
admet-2043	22	9	cellular	cellular	ADJ
admet-2043	22	10	components	component	NOUN
admet-2043	22	11	:	:	PUNCT
admet-2043	22	12	endothelial	endothelial	ADJ
admet-2043	22	13	cells	cell	NOUN
admet-2043	22	14	(	(	PUNCT
admet-2043	22	15	ecs	ec	NOUN
admet-2043	22	16	)	)	PUNCT
admet-2043	22	17	and	and	CCONJ
admet-2043	22	18	mural	mural	ADJ
admet-2043	22	19	cells	cell	NOUN
admet-2043	22	20	(	(	PUNCT
admet-2043	22	21	mcs	mcs	NOUN
admet-2043	22	22	)	)	PUNCT
admet-2043	22	23	.	.	PUNCT
admet-2043	23	1	endothelial	endothelial	ADJ
admet-2043	23	2	cells	cell	NOUN
admet-2043	23	3	,	,	PUNCT
admet-2043	23	4	which	which	PRON
admet-2043	23	5	constitute	constitute	VERB
admet-2043	23	6	the	the	DET
admet-2043	23	7	inner	inner	ADJ
admet-2043	23	8	lining	lining	NOUN
admet-2043	23	9	of	of	ADP
admet-2043	23	10	blood	blood	NOUN
admet-2043	23	11	vessels	vessel	NOUN
admet-2043	23	12	,	,	PUNCT
admet-2043	23	13	are	be	AUX
admet-2043	23	14	modified	modify	VERB
admet-2043	23	15	simple	simple	ADJ
admet-2043	23	16	squamous	squamous	ADJ
admet-2043	23	17	epithelial	epithelial	ADJ
admet-2043	23	18	cells	cell	NOUN
admet-2043	23	19	originating	originate	VERB
admet-2043	23	20	from	from	ADP
admet-2043	23	21	the	the	DET
admet-2043	23	22	mesoderm	mesoderm	NOUN
admet-2043	23	23	.	.	PUNCT
admet-2043	24	1	the	the	DET
admet-2043	24	2	ecs	ecs	PROPN
admet-2043	24	3	exhibit	exhibit	VERB
admet-2043	24	4	a	a	DET
admet-2043	24	5	microvascular	microvascular	ADJ
admet-2043	24	6	phenotype	phenotype	NOUN
admet-2043	24	7	and	and	CCONJ
admet-2043	24	8	display	display	VERB
admet-2043	24	9	a	a	DET
admet-2043	24	10	thickness	thickness	NOUN
admet-2043	24	11	that	that	PRON
admet-2043	24	12	is	be	AUX
admet-2043	24	13	39	39	NUM
admet-2043	24	14	%	%	NOUN
admet-2043	24	15	lower	low	ADJ
admet-2043	24	16	than	than	ADP
admet-2043	24	17	that	that	PRON
admet-2043	24	18	of	of	ADP
admet-2043	24	19	the	the	DET
admet-2043	24	20	muscular	muscular	ADJ
admet-2043	24	21	ecs	ec	NOUN
admet-2043	24	22	[	[	X
admet-2043	24	23	3	3	NUM
admet-2043	24	24	]	]	PUNCT
admet-2043	24	25	.	.	PUNCT
admet-2043	25	1	the	the	DET
admet-2043	25	2	ecs	ecs	PROPN
admet-2043	25	3	of	of	ADP
admet-2043	25	4	the	the	DET
admet-2043	25	5	blood	blood	NOUN
admet-2043	25	6	-	-	PUNCT
admet-2043	25	7	brain	brain	NOUN
admet-2043	25	8	barrier	barrier	NOUN
admet-2043	25	9	exhibit	exhibit	VERB
admet-2043	25	10	distinctive	distinctive	ADJ
admet-2043	25	11	features	feature	NOUN
admet-2043	25	12	,	,	PUNCT
admet-2043	25	13	enabling	enable	VERB
admet-2043	25	14	them	they	PRON
admet-2043	25	15	to	to	PART
admet-2043	25	16	govern	govern	VERB
admet-2043	25	17	the	the	DET
admet-2043	25	18	transport	transport	NOUN
admet-2043	25	19	of	of	ADP
admet-2043	25	20	ions	ion	NOUN
admet-2043	25	21	,	,	PUNCT
admet-2043	25	22	molecules	molecule	NOUN
admet-2043	25	23	,	,	PUNCT
admet-2043	25	24	and	and	CCONJ
admet-2043	25	25	cells	cell	NOUN
admet-2043	25	26	across	across	ADP
admet-2043	25	27	the	the	DET
admet-2043	25	28	interface	interface	NOUN
admet-2043	25	29	,	,	PUNCT
admet-2043	25	30	separating	separate	VERB
admet-2043	25	31	the	the	DET
admet-2043	25	32	bloodstream	bloodstream	NOUN
admet-2043	25	33	and	and	CCONJ
admet-2043	25	34	the	the	DET
admet-2043	25	35	brain	brain	NOUN
admet-2043	25	36	.	.	PUNCT
admet-2043	26	1	the	the	DET
admet-2043	26	2	observed	observe	VERB
admet-2043	26	3	phenomenon	phenomenon	NOUN
admet-2043	26	4	exhibits	exhibit	VERB
admet-2043	26	5	a	a	DET
admet-2043	26	6	low	low	ADJ
admet-2043	26	7	incidence	incidence	NOUN
admet-2043	26	8	of	of	ADP
admet-2043	26	9	cytopempsis	cytopempsis	NOUN
admet-2043	26	10	,	,	PUNCT
admet-2043	26	11	a	a	DET
admet-2043	26	12	transcellular	transcellular	NOUN
admet-2043	26	13	transport	transport	NOUN
admet-2043	26	14	mechanism	mechanism	NOUN
admet-2043	26	15	facilitating	facilitate	VERB
admet-2043	26	16	the	the	DET
admet-2043	26	17	intracellular	intracellular	ADJ
admet-2043	26	18	movement	movement	NOUN
admet-2043	26	19	of	of	ADP
admet-2043	26	20	diverse	diverse	ADJ
admet-2043	26	21	macromolecules	macromolecule	NOUN
admet-2043	26	22	.	.	PUNCT
admet-2043	27	1	the	the	DET
admet-2043	27	2	intercellular	intercellular	ADJ
admet-2043	27	3	tight	tight	ADJ
admet-2043	27	4	junction	junction	NOUN
admet-2043	27	5	(	(	PUNCT
admet-2043	27	6	tj	tj	NOUN
admet-2043	27	7	)	)	PUNCT
admet-2043	27	8	proteins	protein	NOUN
admet-2043	27	9	expressed	express	VERB
admet-2043	27	10	by	by	ADP
admet-2043	27	11	these	these	DET
admet-2043	27	12	endothelial	endothelial	ADJ
admet-2043	27	13	cells	cell	NOUN
admet-2043	27	14	play	play	VERB
admet-2043	27	15	a	a	DET
admet-2043	27	16	crucial	crucial	ADJ
admet-2043	27	17	role	role	NOUN
admet-2043	27	18	in	in	ADP
admet-2043	27	19	impeding	impede	VERB
admet-2043	27	20	paracellular	paracellular	ADJ
admet-2043	27	21	transport	transport	NOUN
admet-2043	27	22	[	[	X
admet-2043	27	23	4	4	NUM
admet-2043	27	24	]	]	PUNCT
admet-2043	27	25	.	.	PUNCT
admet-2043	28	1	mural	mural	ADJ
admet-2043	28	2	cells	cell	NOUN
admet-2043	28	3	,	,	PUNCT
admet-2043	28	4	herein	herein	NOUN
admet-2043	28	5	referred	refer	VERB
admet-2043	28	6	to	to	ADP
admet-2043	28	7	as	as	ADP
admet-2043	28	8	mcs	mcs	PROPN
admet-2043	28	9	,	,	PUNCT
admet-2043	28	10	comprise	comprise	VERB
admet-2043	28	11	smooth	smooth	ADJ
admet-2043	28	12	muscle	muscle	NOUN
admet-2043	28	13	cells	cell	NOUN
admet-2043	28	14	enveloped	envelop	VERB
admet-2043	28	15	by	by	ADP
admet-2043	28	16	large	large	ADJ
admet-2043	28	17	vessels	vessel	NOUN
admet-2043	28	18	and	and	CCONJ
admet-2043	28	19	pericytes	pericyte	NOUN
admet-2043	28	20	.	.	PUNCT
admet-2043	29	1	pericytes	pericyte	NOUN
admet-2043	29	2	are	be	AUX
admet-2043	29	3	recognised	recognise	VERB
admet-2043	29	4	to	to	PART
admet-2043	29	5	harbour	harbour	VERB
admet-2043	29	6	contractile	contractile	NOUN
admet-2043	29	7	proteins	protein	NOUN
admet-2043	29	8	and	and	CCONJ
admet-2043	29	9	illustrate	illustrate	VERB
admet-2043	29	10	an	an	DET
admet-2043	29	11	impulse	impulse	NOUN
admet-2043	29	12	to	to	PART
admet-2043	29	13	contract	contract	VERB
admet-2043	29	14	,	,	PUNCT
admet-2043	29	15	thereby	thereby	ADV
admet-2043	29	16	regulating	regulate	VERB
admet-2043	29	17	the	the	DET
admet-2043	29	18	diameter	diameter	NOUN
admet-2043	29	19	of	of	ADP
admet-2043	29	20	the	the	DET
admet-2043	29	21	capillaries	capillary	NOUN
admet-2043	29	22	[	[	X
admet-2043	29	23	3	3	NUM
admet-2043	29	24	]	]	PUNCT
admet-2043	29	25	.	.	PUNCT
admet-2043	30	1	the	the	DET
admet-2043	30	2	bbb	bbb	PROPN
admet-2043	30	3	is	be	AUX
admet-2043	30	4	comprised	comprise	VERB
admet-2043	30	5	of	of	ADP
admet-2043	30	6	a	a	DET
admet-2043	30	7	series	series	NOUN
admet-2043	30	8	of	of	ADP
admet-2043	30	9	uninterrupted	uninterrupted	ADJ
admet-2043	30	10	ecs	ec	NOUN
admet-2043	30	11	that	that	PRON
admet-2043	30	12	are	be	AUX
admet-2043	30	13	reinforced	reinforce	VERB
admet-2043	30	14	by	by	ADP
admet-2043	30	15	tight	tight	ADJ
admet-2043	30	16	junctions	junction	NOUN
admet-2043	30	17	(	(	PUNCT
admet-2043	30	18	tjs	tjs	NOUN
admet-2043	30	19	)	)	PUNCT
admet-2043	30	20	,	,	PUNCT
admet-2043	30	21	adherent	adherent	NOUN
admet-2043	30	22	junctions	junction	NOUN
admet-2043	30	23	(	(	PUNCT
admet-2043	30	24	ajs	ajs	PROPN
admet-2043	30	25	)	)	PUNCT
admet-2043	30	26	,	,	PUNCT
admet-2043	30	27	and	and	CCONJ
admet-2043	30	28	gap	gap	NOUN
admet-2043	30	29	junctions	junction	NOUN
admet-2043	30	30	(	(	PUNCT
admet-2043	30	31	gjs	gjs	NOUN
admet-2043	30	32	)	)	PUNCT
admet-2043	30	33	.	.	PUNCT
admet-2043	31	1	the	the	DET
admet-2043	31	2	tjs	tjs	NOUN
admet-2043	31	3	are	be	AUX
admet-2043	31	4	a	a	DET
admet-2043	31	5	crucial	crucial	ADJ
admet-2043	31	6	component	component	NOUN
admet-2043	31	7	of	of	ADP
admet-2043	31	8	the	the	DET
admet-2043	31	9	bbb	bbb	PROPN
admet-2043	31	10	,	,	PUNCT
admet-2043	31	11	providing	provide	VERB
admet-2043	31	12	increased	increase	VERB
admet-2043	31	13	trans	trans	ADJ
admet-2043	31	14	-	-	ADJ
admet-2043	31	15	endothelial	endothelial	ADJ
admet-2043	31	16	resistance	resistance	NOUN
admet-2043	31	17	within	within	ADP
admet-2043	31	18	the	the	DET
admet-2043	31	19	bbb	bbb	NOUN
admet-2043	31	20	[	[	X
admet-2043	31	21	5	5	NUM
admet-2043	31	22	]	]	PUNCT
admet-2043	31	23	.	.	PUNCT
admet-2043	32	1	the	the	DET
admet-2043	32	2	present	present	ADJ
admet-2043	32	3	study	study	NOUN
admet-2043	32	4	elucidates	elucidate	VERB
admet-2043	32	5	that	that	SCONJ
admet-2043	32	6	the	the	DET
admet-2043	32	7	aforementioned	aforementioned	ADJ
admet-2043	32	8	intercellular	intercellular	ADJ
admet-2043	32	9	junctions	junction	NOUN
admet-2043	32	10	function	function	VERB
admet-2043	32	11	as	as	ADP
admet-2043	32	12	drug	drug	NOUN
admet-2043	32	13	monitoring	monitoring	NOUN
admet-2043	32	14	agents	agent	NOUN
admet-2043	32	15	via	via	ADP
admet-2043	32	16	cellular	cellular	ADJ
admet-2043	32	17	tethering	tethering	NOUN
admet-2043	32	18	,	,	PUNCT
admet-2043	32	19	resulting	result	VERB
admet-2043	32	20	in	in	ADP
admet-2043	32	21	intercellular	intercellular	ADJ
admet-2043	32	22	space	space	NOUN
admet-2043	32	23	occlusion	occlusion	NOUN
admet-2043	32	24	[	[	X
admet-2043	32	25	6	6	NUM
admet-2043	32	26	]	]	PUNCT
admet-2043	32	27	.	.	PUNCT
admet-2043	33	1	the	the	DET
admet-2043	33	2	first	first	ADJ
admet-2043	33	3	evidence	evidence	NOUN
admet-2043	33	4	of	of	ADP
admet-2043	33	5	the	the	DET
admet-2043	33	6	presence	presence	NOUN
admet-2043	33	7	of	of	ADP
admet-2043	33	8	bbb	bbb	PROPN
admet-2043	33	9	was	be	AUX
admet-2043	33	10	seen	see	VERB
admet-2043	33	11	in	in	ADP
admet-2043	33	12	the	the	DET
admet-2043	33	13	late	late	ADJ
admet-2043	33	14	1800	1800	NUM
admet-2043	33	15	’s	’s	NOUN
admet-2043	33	16	.	.	PUNCT
admet-2043	34	1	the	the	DET
admet-2043	34	2	discovery	discovery	NOUN
admet-2043	34	3	of	of	ADP
admet-2043	34	4	the	the	DET
admet-2043	34	5	physical	physical	ADJ
admet-2043	34	6	layer	layer	NOUN
admet-2043	34	7	of	of	ADP
admet-2043	34	8	bbb	bbb	PROPN
admet-2043	34	9	was	be	AUX
admet-2043	34	10	made	make	VERB
admet-2043	34	11	in	in	ADP
admet-2043	34	12	the	the	DET
admet-2043	34	13	1960s	1960	NOUN
admet-2043	34	14	.	.	PUNCT
admet-2043	35	1	the	the	DET
admet-2043	35	2	transmembrane	transmembrane	NOUN
admet-2043	35	3	multiprotein	multiprotein	ADJ
admet-2043	35	4	junction	junction	NOUN
admet-2043	35	5	was	be	AUX
admet-2043	35	6	discovered	discover	VERB
admet-2043	35	7	in	in	ADP
admet-2043	35	8	the	the	DET
admet-2043	35	9	era	era	NOUN
admet-2043	35	10	of	of	ADP
admet-2043	35	11	1980s	1980s	NUM
admet-2043	35	12	.	.	PUNCT
admet-2043	36	1	figure	figure	NOUN
admet-2043	36	2	2	2	NUM
admet-2043	36	3	represents	represent	VERB
admet-2043	36	4	the	the	DET
admet-2043	36	5	roadmap	roadmap	NOUN
admet-2043	36	6	to	to	ADP
admet-2043	36	7	the	the	DET
admet-2043	36	8	discovery	discovery	NOUN
admet-2043	36	9	and	and	CCONJ
admet-2043	36	10	development	development	NOUN
admet-2043	36	11	of	of	ADP
admet-2043	36	12	the	the	DET
admet-2043	36	13	bbb	bbb	PROPN
admet-2043	36	14	.	.	PUNCT
admet-2043	37	1	figure	figure	NOUN
admet-2043	37	2	1	1	NUM
admet-2043	37	3	.	.	PUNCT
admet-2043	37	4	pictorial	pictorial	ADJ
admet-2043	37	5	representation	representation	NOUN
admet-2043	37	6	of	of	ADP
admet-2043	37	7	the	the	DET
admet-2043	37	8	blood	blood	NOUN
admet-2043	37	9	-	-	PUNCT
admet-2043	37	10	brain	brain	NOUN
admet-2043	37	11	barrier	barrier	NOUN
admet-2043	37	12	admet	admet	PROPN
admet-2043	37	13	&	&	CCONJ
admet-2043	37	14	dmpk	dmpk	PROPN
admet-2043	37	15	12(1	12(1	PROPN
admet-2043	37	16	)	)	PUNCT
admet-2043	37	17	(	(	PUNCT
admet-2043	37	18	2024	2024	NUM
admet-2043	37	19	)	)	PUNCT
admet-2043	37	20	63	63	NUM
admet-2043	37	21	-	-	SYM
admet-2043	37	22	105	105	NUM
admet-2043	37	23	nanomaterials	nanomaterial	NOUN
admet-2043	37	24	as	as	ADP
admet-2043	37	25	drug	drug	NOUN
admet-2043	37	26	delivery	delivery	NOUN
admet-2043	37	27	agents	agent	NOUN
admet-2043	37	28	for	for	ADP
admet-2043	37	29	overcoming	overcome	VERB
admet-2043	37	30	bbb	bbb	PROPN
admet-2043	37	31	doi	doi	NOUN
admet-2043	37	32	:	:	PUNCT
admet-2043	37	33	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	37	34	65	65	NUM
admet-2043	37	35	figure	figure	NOUN
admet-2043	37	36	2	2	NUM
admet-2043	37	37	.	.	PUNCT
admet-2043	37	38	roadmap	roadmap	NOUN
admet-2043	37	39	of	of	ADP
admet-2043	37	40	discovery	discovery	NOUN
admet-2043	37	41	and	and	CCONJ
admet-2043	37	42	development	development	NOUN
admet-2043	37	43	of	of	ADP
admet-2043	37	44	blood	blood	NOUN
admet-2043	37	45	-	-	PUNCT
admet-2043	37	46	brain	brain	NOUN
admet-2043	37	47	barrier	barrier	NOUN
admet-2043	37	48	challenges	challenge	NOUN
admet-2043	37	49	in	in	ADP
admet-2043	37	50	drug	drug	NOUN
admet-2043	37	51	delivery	delivery	NOUN
admet-2043	37	52	to	to	ADP
admet-2043	37	53	bbb	bbb	PROPN
admet-2043	37	54	at	at	ADP
admet-2043	37	55	present	present	ADJ
admet-2043	37	56	,	,	PUNCT
admet-2043	37	57	there	there	PRON
admet-2043	37	58	exists	exist	VERB
admet-2043	37	59	a	a	DET
admet-2043	37	60	global	global	ADJ
admet-2043	37	61	population	population	NOUN
admet-2043	37	62	of	of	ADP
admet-2043	37	63	approximately	approximately	ADV
admet-2043	37	64	1.5	1.5	NUM
admet-2043	37	65	billion	billion	NUM
admet-2043	37	66	individuals	individual	NOUN
admet-2043	37	67	who	who	PRON
admet-2043	37	68	are	be	AUX
admet-2043	37	69	afflicted	afflict	VERB
admet-2043	37	70	with	with	ADP
admet-2043	37	71	various	various	ADJ
admet-2043	37	72	cns	cns	NOUN
admet-2043	37	73	disorders	disorder	NOUN
admet-2043	37	74	at	at	ADP
admet-2043	37	75	any	any	DET
admet-2043	37	76	given	give	VERB
admet-2043	37	77	point	point	NOUN
admet-2043	37	78	in	in	ADP
admet-2043	37	79	time	time	NOUN
admet-2043	37	80	.	.	PUNCT
admet-2043	38	1	the	the	DET
admet-2043	38	2	primary	primary	ADJ
admet-2043	38	3	impediment	impediment	NOUN
admet-2043	38	4	to	to	ADP
admet-2043	38	5	effective	effective	ADJ
admet-2043	38	6	drug	drug	NOUN
admet-2043	38	7	delivery	delivery	NOUN
admet-2043	38	8	to	to	ADP
admet-2043	38	9	the	the	DET
admet-2043	38	10	brain	brain	NOUN
admet-2043	38	11	is	be	AUX
admet-2043	38	12	the	the	DET
admet-2043	38	13	bbb	bbb	NOUN
admet-2043	38	14	and	and	CCONJ
admet-2043	38	15	the	the	DET
admet-2043	38	16	associated	associated	ADJ
admet-2043	38	17	enzymatic	enzymatic	ADJ
admet-2043	38	18	activity	activity	NOUN
admet-2043	38	19	that	that	PRON
admet-2043	38	20	regulates	regulate	VERB
admet-2043	38	21	the	the	DET
admet-2043	38	22	influx	influx	NOUN
admet-2043	38	23	of	of	ADP
admet-2043	38	24	molecules	molecule	NOUN
admet-2043	38	25	into	into	ADP
admet-2043	38	26	the	the	DET
admet-2043	38	27	cns	cns	NOUN
admet-2043	39	1	[	[	X
admet-2043	39	2	7	7	NUM
admet-2043	39	3	]	]	PUNCT
admet-2043	39	4	.	.	PUNCT
admet-2043	40	1	figure	figure	NOUN
admet-2043	40	2	3	3	NUM
admet-2043	40	3	elaborates	elaborate	VERB
admet-2043	40	4	on	on	ADP
admet-2043	40	5	the	the	DET
admet-2043	40	6	factors	factor	NOUN
admet-2043	40	7	that	that	PRON
admet-2043	40	8	affect	affect	VERB
admet-2043	40	9	drug	drug	NOUN
admet-2043	40	10	delivery	delivery	NOUN
admet-2043	40	11	across	across	ADP
admet-2043	40	12	the	the	DET
admet-2043	40	13	bbb	bbb	PROPN
admet-2043	40	14	.	.	PUNCT
admet-2043	41	1	figure	figure	NOUN
admet-2043	41	2	3	3	NUM
admet-2043	41	3	.	.	PUNCT
admet-2043	42	1	factors	factor	NOUN
admet-2043	42	2	affecting	affect	VERB
admet-2043	42	3	drug	drug	NOUN
admet-2043	42	4	delivery	delivery	NOUN
admet-2043	42	5	across	across	ADP
admet-2043	42	6	bbb	bbb	NOUN
admet-2043	42	7	importance	importance	NOUN
admet-2043	42	8	of	of	ADP
admet-2043	42	9	nanoparticles	nanoparticle	NOUN
admet-2043	42	10	in	in	ADP
admet-2043	42	11	overcoming	overcome	VERB
admet-2043	42	12	bbb	bbb	PROPN
admet-2043	42	13	limitations	limitation	NOUN
admet-2043	42	14	the	the	DET
admet-2043	42	15	administration	administration	NOUN
admet-2043	42	16	of	of	ADP
admet-2043	42	17	pharmacological	pharmacological	ADJ
admet-2043	42	18	agents	agent	NOUN
admet-2043	42	19	to	to	ADP
admet-2043	42	20	the	the	DET
admet-2043	42	21	brain	brain	NOUN
admet-2043	42	22	can	can	AUX
admet-2043	42	23	be	be	AUX
admet-2043	42	24	achieved	achieve	VERB
admet-2043	42	25	through	through	ADP
admet-2043	42	26	a	a	DET
admet-2043	42	27	multitude	multitude	NOUN
admet-2043	42	28	of	of	ADP
admet-2043	42	29	delivery	delivery	NOUN
admet-2043	42	30	methods	method	NOUN
admet-2043	42	31	.	.	PUNCT
admet-2043	43	1	initially	initially	ADV
admet-2043	43	2	,	,	PUNCT
admet-2043	43	3	the	the	DET
admet-2043	43	4	administration	administration	NOUN
admet-2043	43	5	of	of	ADP
admet-2043	43	6	pharmaceutical	pharmaceutical	ADJ
admet-2043	43	7	agents	agent	NOUN
admet-2043	43	8	can	can	AUX
admet-2043	43	9	be	be	AUX
admet-2043	43	10	achieved	achieve	VERB
admet-2043	43	11	via	via	ADP
admet-2043	43	12	localised	localised	ADJ
admet-2043	43	13	delivery	delivery	NOUN
admet-2043	43	14	.	.	PUNCT
admet-2043	44	1	the	the	DET
admet-2043	44	2	administration	administration	NOUN
admet-2043	44	3	of	of	ADP
admet-2043	44	4	therapeutic	therapeutic	ADJ
admet-2043	44	5	agents	agent	NOUN
admet-2043	44	6	in	in	ADP
admet-2043	44	7	a	a	DET
admet-2043	44	8	localised	localise	VERB
admet-2043	44	9	manner	manner	NOUN
admet-2043	44	10	can	can	AUX
admet-2043	44	11	be	be	AUX
admet-2043	44	12	achieved	achieve	VERB
admet-2043	44	13	through	through	ADP
admet-2043	44	14	the	the	DET
admet-2043	44	15	utilisation	utilisation	NOUN
admet-2043	44	16	of	of	ADP
admet-2043	44	17	catheter	catheter	NOUN
admet-2043	44	18	-	-	PUNCT
admet-2043	44	19	based	base	VERB
admet-2043	44	20	injection	injection	NOUN
admet-2043	44	21	or	or	CCONJ
admet-2043	44	22	convection	convection	NOUN
admet-2043	44	23	-	-	PUNCT
admet-2043	44	24	enhanced	enhance	VERB
admet-2043	44	25	delivery	delivery	NOUN
admet-2043	44	26	systems	system	NOUN
admet-2043	44	27	.	.	PUNCT
admet-2043	45	1	biodegradable	biodegradable	ADJ
admet-2043	45	2	implants	implant	NOUN
admet-2043	45	3	have	have	VERB
admet-2043	45	4	the	the	DET
admet-2043	45	5	potential	potential	NOUN
admet-2043	45	6	to	to	PART
admet-2043	45	7	provide	provide	VERB
admet-2043	45	8	sustained	sustained	ADJ
admet-2043	45	9	drug	drug	NOUN
admet-2043	45	10	release	release	NOUN
admet-2043	45	11	capabilities	capability	NOUN
admet-2043	45	12	[	[	X
admet-2043	45	13	8	8	NUM
admet-2043	45	14	]	]	PUNCT
admet-2043	45	15	.	.	PUNCT
admet-2043	46	1	the	the	DET
admet-2043	46	2	aforementioned	aforementione	VERB
admet-2043	46	3	procedures	procedure	NOUN
admet-2043	46	4	are	be	AUX
admet-2043	46	5	inherently	inherently	ADV
admet-2043	46	6	invasive	invasive	ADJ
admet-2043	46	7	due	due	ADP
admet-2043	46	8	to	to	ADP
admet-2043	46	9	their	their	PRON
admet-2043	46	10	surgical	surgical	ADJ
admet-2043	46	11	nature	nature	NOUN
admet-2043	46	12	.	.	PUNCT
admet-2043	47	1	this	this	DET
admet-2043	47	2	area	area	NOUN
admet-2043	47	3	presents	present	VERB
admet-2043	47	4	a	a	DET
admet-2043	47	5	potential	potential	ADJ
admet-2043	47	6	opportunity	opportunity	NOUN
admet-2043	47	7	for	for	ADP
admet-2043	47	8	localised	localised	ADJ
admet-2043	47	9	drug	drug	NOUN
admet-2043	47	10	delivery	delivery	NOUN
admet-2043	47	11	,	,	PUNCT
admet-2043	47	12	potentially	potentially	ADV
admet-2043	47	13	representing	represent	VERB
admet-2043	47	14	a	a	DET
admet-2043	47	15	novel	novel	ADJ
admet-2043	47	16	frontier	frontier	NOUN
admet-2043	47	17	in	in	ADP
admet-2043	47	18	the	the	DET
admet-2043	47	19	field	field	NOUN
admet-2043	47	20	.	.	PUNCT
admet-2043	48	1	an	an	DET
admet-2043	48	2	alternative	alternative	ADJ
admet-2043	48	3	method	method	NOUN
admet-2043	48	4	for	for	ADP
admet-2043	48	5	drug	drug	NOUN
admet-2043	48	6	delivery	delivery	NOUN
admet-2043	48	7	involves	involve	VERB
admet-2043	48	8	administration	administration	NOUN
admet-2043	48	9	via	via	ADP
admet-2043	48	10	the	the	DET
admet-2043	48	11	intranasal	intranasal	ADJ
admet-2043	48	12	route	route	NOUN
admet-2043	48	13	.	.	PUNCT
admet-2043	49	1	upon	upon	SCONJ
admet-2043	49	2	arrival	arrival	NOUN
admet-2043	49	3	at	at	ADP
admet-2043	49	4	the	the	DET
admet-2043	49	5	nasal	nasal	ADJ
admet-2043	49	6	cavity	cavity	NOUN
admet-2043	49	7	,	,	PUNCT
admet-2043	49	8	the	the	DET
admet-2043	49	9	transportation	transportation	NOUN
admet-2043	49	10	process	process	NOUN
admet-2043	49	11	may	may	AUX
admet-2043	49	12	proceed	proceed	VERB
admet-2043	49	13	via	via	ADP
admet-2043	49	14	the	the	DET
admet-2043	49	15	olfactory	olfactory	NOUN
admet-2043	49	16	and	and	CCONJ
admet-2043	49	17	trigeminal	trigeminal	ADJ
admet-2043	49	18	pathways	pathway	NOUN
admet-2043	49	19	,	,	PUNCT
admet-2043	49	20	ultimately	ultimately	ADV
admet-2043	49	21	leading	lead	VERB
admet-2043	49	22	access	access	NOUN
admet-2043	49	23	to	to	ADP
admet-2043	49	24	the	the	DET
admet-2043	49	25	cns	cns	NOUN
admet-2043	50	1	[	[	X
admet-2043	50	2	9	9	NUM
admet-2043	50	3	]	]	PUNCT
admet-2043	50	4	.	.	PUNCT
admet-2043	51	1	the	the	DET
admet-2043	51	2	non	non	ADJ
admet-2043	51	3	-	-	ADJ
admet-2043	51	4	invasive	invasive	ADJ
admet-2043	51	5	and	and	CCONJ
admet-2043	51	6	innovative	innovative	ADJ
admet-2043	51	7	approach	approach	NOUN
admet-2043	51	8	has	have	AUX
admet-2043	51	9	garnered	garner	VERB
admet-2043	51	10	the	the	DET
admet-2043	51	11	interest	interest	NOUN
admet-2043	51	12	of	of	ADP
admet-2043	51	13	numerous	numerous	ADJ
admet-2043	51	14	researchers	researcher	NOUN
admet-2043	51	15	.	.	PUNCT
admet-2043	52	1	the	the	DET
admet-2043	52	2	nasal	nasal	PROPN
admet-2043	52	3	administration	administration	PROPN
admet-2043	52	4	modality	modality	NOUN
admet-2043	52	5	exhibits	exhibit	VERB
admet-2043	52	6	certain	certain	ADJ
admet-2043	52	7	limitations	limitation	NOUN
admet-2043	52	8	,	,	PUNCT
admet-2043	52	9	such	such	ADJ
admet-2043	52	10	as	as	ADP
admet-2043	52	11	the	the	DET
admet-2043	52	12	lack	lack	NOUN
admet-2043	52	13	of	of	ADP
admet-2043	52	14	consistency	consistency	NOUN
admet-2043	52	15	in	in	ADP
admet-2043	52	16	the	the	DET
admet-2043	52	17	administered	administer	VERB
admet-2043	52	18	dosage	dosage	NOUN
admet-2043	52	19	of	of	ADP
admet-2043	52	20	the	the	DET
admet-2043	52	21	formulation	formulation	NOUN
admet-2043	52	22	[	[	X
admet-2043	52	23	10	10	NUM
admet-2043	52	24	]	]	PUNCT
admet-2043	52	25	.	.	PUNCT
admet-2043	53	1	one	one	NUM
admet-2043	53	2	potential	potential	ADJ
admet-2043	53	3	avenue	avenue	NOUN
admet-2043	53	4	for	for	ADP
admet-2043	53	5	improving	improve	VERB
admet-2043	53	6	drug	drug	NOUN
admet-2043	53	7	delivery	delivery	NOUN
admet-2043	53	8	involves	involve	VERB
admet-2043	53	9	augmenting	augment	VERB
admet-2043	53	10	the	the	DET
admet-2043	53	11	capacity	capacity	NOUN
admet-2043	53	12	of	of	ADP
admet-2043	53	13	drugs	drug	NOUN
admet-2043	53	14	to	to	PART
admet-2043	53	15	traverse	traverse	VERB
admet-2043	53	16	the	the	DET
admet-2043	53	17	bbb	bbb	NOUN
admet-2043	53	18	through	through	ADP
admet-2043	53	19	modifications	modification	NOUN
admet-2043	53	20	to	to	ADP
admet-2043	53	21	their	their	PRON
admet-2043	53	22	molecular	molecular	ADJ
admet-2043	53	23	architecture	architecture	NOUN
admet-2043	53	24	or	or	CCONJ
admet-2043	53	25	the	the	DET
admet-2043	53	26	implementation	implementation	NOUN
admet-2043	53	27	of	of	ADP
admet-2043	53	28	prodrug	prodrug	NOUN
admet-2043	53	29	strategies	strategy	NOUN
admet-2043	53	30	.	.	PUNCT
admet-2043	54	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	54	2	m.	m.	NOUN
admet-2043	54	3	kulkarni	kulkarni	PROPN
admet-2043	54	4	et	et	PROPN
admet-2043	54	5	al	al	PROPN
admet-2043	54	6	.	.	PROPN
admet-2043	54	7	admet	admet	PROPN
admet-2043	54	8	&	&	CCONJ
admet-2043	54	9	dmpk	dmpk	PROPN
admet-2043	54	10	12(1	12(1	PROPN
admet-2043	54	11	)	)	PUNCT
admet-2043	54	12	(	(	PUNCT
admet-2043	54	13	2024	2024	NUM
admet-2043	54	14	)	)	PUNCT
admet-2043	54	15	63	63	NUM
admet-2043	54	16	-	-	SYM
admet-2043	54	17	105	105	NUM
admet-2043	54	18	66	66	NUM
admet-2043	54	19	levodopa	levodopa	NOUN
admet-2043	54	20	,	,	PUNCT
admet-2043	54	21	a	a	DET
admet-2043	54	22	prodrug	prodrug	NOUN
admet-2043	54	23	for	for	ADP
admet-2043	54	24	dopamine	dopamine	NOUN
admet-2043	54	25	,	,	PUNCT
admet-2043	54	26	is	be	AUX
admet-2043	54	27	a	a	DET
admet-2043	54	28	notable	notable	ADJ
admet-2043	54	29	illustration	illustration	NOUN
admet-2043	54	30	of	of	ADP
admet-2043	54	31	this	this	DET
admet-2043	54	32	approach	approach	NOUN
admet-2043	54	33	and	and	CCONJ
admet-2043	54	34	is	be	AUX
admet-2043	54	35	employed	employ	VERB
admet-2043	54	36	to	to	PART
admet-2043	54	37	treat	treat	VERB
admet-2043	54	38	parkinson	parkinson	NOUN
admet-2043	54	39	's	's	PART
admet-2043	54	40	disease	disease	NOUN
admet-2043	54	41	.	.	PUNCT
admet-2043	55	1	the	the	DET
admet-2043	55	2	feasibility	feasibility	NOUN
admet-2043	55	3	of	of	ADP
admet-2043	55	4	this	this	DET
admet-2043	55	5	option	option	NOUN
admet-2043	55	6	is	be	AUX
admet-2043	55	7	often	often	ADV
admet-2043	55	8	constrained	constrain	VERB
admet-2043	55	9	by	by	ADP
admet-2043	55	10	the	the	DET
admet-2043	55	11	limitations	limitation	NOUN
admet-2043	55	12	associated	associate	VERB
admet-2043	55	13	with	with	ADP
admet-2043	55	14	molecular	molecular	ADJ
admet-2043	55	15	modification	modification	NOUN
admet-2043	55	16	or	or	CCONJ
admet-2043	55	17	fabrication	fabrication	NOUN
admet-2043	55	18	.	.	PUNCT
admet-2043	56	1	in	in	ADP
admet-2043	56	2	addition	addition	NOUN
admet-2043	56	3	,	,	PUNCT
admet-2043	56	4	the	the	DET
admet-2043	56	5	potential	potential	NOUN
admet-2043	56	6	for	for	ADP
admet-2043	56	7	reversible	reversible	ADJ
admet-2043	56	8	disruption	disruption	NOUN
admet-2043	56	9	may	may	AUX
admet-2043	56	10	be	be	AUX
admet-2043	56	11	explored	explore	VERB
admet-2043	56	12	through	through	ADP
admet-2043	56	13	the	the	DET
admet-2043	56	14	utilisation	utilisation	NOUN
admet-2043	56	15	of	of	ADP
admet-2043	56	16	hyperosmolar	hyperosmolar	ADJ
admet-2043	56	17	agents	agent	NOUN
admet-2043	56	18	such	such	ADJ
admet-2043	56	19	as	as	ADP
admet-2043	56	20	mannitol	mannitol	NOUN
admet-2043	56	21	injection	injection	NOUN
admet-2043	56	22	[	[	X
admet-2043	56	23	11	11	NUM
admet-2043	56	24	]	]	PUNCT
admet-2043	56	25	or	or	CCONJ
admet-2043	56	26	by	by	ADP
admet-2043	56	27	using	use	VERB
admet-2043	56	28	physical	physical	ADJ
admet-2043	56	29	methodology	methodology	NOUN
admet-2043	56	30	such	such	ADJ
admet-2043	56	31	as	as	ADP
admet-2043	56	32	ultrasound	ultrasound	NOUN
admet-2043	56	33	[	[	X
admet-2043	56	34	12	12	NUM
admet-2043	56	35	]	]	PUNCT
admet-2043	56	36	,	,	PUNCT
admet-2043	56	37	thereby	thereby	ADV
admet-2043	56	38	presenting	present	VERB
admet-2043	56	39	a	a	DET
admet-2043	56	40	viable	viable	ADJ
admet-2043	56	41	alternative	alternative	NOUN
admet-2043	56	42	.	.	PUNCT
admet-2043	57	1	however	however	ADV
admet-2043	57	2	,	,	PUNCT
admet-2043	57	3	the	the	DET
admet-2043	57	4	disruption	disruption	NOUN
admet-2043	57	5	of	of	ADP
admet-2043	57	6	the	the	DET
admet-2043	57	7	bbb	bbb	PROPN
admet-2043	57	8	can	can	AUX
admet-2043	57	9	result	result	VERB
admet-2043	57	10	in	in	ADP
admet-2043	57	11	considerable	considerable	ADJ
admet-2043	57	12	harm	harm	NOUN
admet-2043	57	13	to	to	ADP
admet-2043	57	14	the	the	DET
admet-2043	57	15	brain	brain	NOUN
admet-2043	57	16	,	,	PUNCT
admet-2043	57	17	as	as	SCONJ
admet-2043	57	18	the	the	DET
admet-2043	57	19	bbb	bbb	PROPN
admet-2043	57	20	serves	serve	VERB
admet-2043	57	21	as	as	ADP
admet-2043	57	22	a	a	DET
admet-2043	57	23	crucial	crucial	ADJ
admet-2043	57	24	protective	protective	ADJ
admet-2043	57	25	barrier	barrier	NOUN
admet-2043	57	26	for	for	ADP
admet-2043	57	27	the	the	DET
admet-2043	57	28	human	human	ADJ
admet-2043	57	29	brain	brain	NOUN
admet-2043	58	1	[	[	X
admet-2043	58	2	13	13	NUM
admet-2043	58	3	]	]	PUNCT
admet-2043	58	4	.	.	PUNCT
admet-2043	59	1	various	various	ADJ
admet-2043	59	2	techniques	technique	NOUN
admet-2043	59	3	are	be	AUX
admet-2043	59	4	available	available	ADJ
admet-2043	59	5	to	to	PART
admet-2043	59	6	explore	explore	VERB
admet-2043	59	7	drug	drug	NOUN
admet-2043	59	8	delivery	delivery	NOUN
admet-2043	59	9	methods	method	NOUN
admet-2043	59	10	to	to	ADP
admet-2043	59	11	the	the	DET
admet-2043	59	12	brain	brain	NOUN
admet-2043	59	13	.	.	PUNCT
admet-2043	60	1	localized	localize	VERB
admet-2043	60	2	drug	drug	NOUN
admet-2043	60	3	delivery	delivery	NOUN
admet-2043	60	4	through	through	ADP
admet-2043	60	5	catheter	catheter	NOUN
admet-2043	60	6	-	-	PUNCT
admet-2043	60	7	based	base	VERB
admet-2043	60	8	injection	injection	NOUN
admet-2043	60	9	,	,	PUNCT
admet-2043	60	10	convection	convection	NOUN
admet-2043	60	11	-	-	PUNCT
admet-2043	60	12	enhanced	enhance	VERB
admet-2043	60	13	delivery	delivery	NOUN
admet-2043	60	14	systems	system	NOUN
admet-2043	60	15	,	,	PUNCT
admet-2043	60	16	and	and	CCONJ
admet-2043	60	17	biodegradable	biodegradable	ADJ
admet-2043	60	18	implants	implant	NOUN
admet-2043	60	19	offer	offer	VERB
admet-2043	60	20	potential	potential	ADJ
admet-2043	60	21	advantages	advantage	NOUN
admet-2043	60	22	.	.	PUNCT
admet-2043	61	1	however	however	ADV
admet-2043	61	2	,	,	PUNCT
admet-2043	61	3	it	it	PRON
admet-2043	61	4	's	be	AUX
admet-2043	61	5	important	important	ADJ
admet-2043	61	6	to	to	PART
admet-2043	61	7	acknowledge	acknowledge	VERB
admet-2043	61	8	the	the	DET
admet-2043	61	9	invasiveness	invasiveness	NOUN
admet-2043	61	10	associated	associate	VERB
admet-2043	61	11	with	with	ADP
admet-2043	61	12	these	these	DET
admet-2043	61	13	surgical	surgical	ADJ
admet-2043	61	14	procedures	procedure	NOUN
admet-2043	61	15	.	.	PUNCT
admet-2043	62	1	despite	despite	SCONJ
admet-2043	62	2	this	this	PRON
admet-2043	62	3	,	,	PUNCT
admet-2043	62	4	the	the	DET
admet-2043	62	5	potential	potential	NOUN
admet-2043	62	6	for	for	ADP
admet-2043	62	7	localized	localized	ADJ
admet-2043	62	8	drug	drug	NOUN
admet-2043	62	9	delivery	delivery	NOUN
admet-2043	62	10	in	in	ADP
admet-2043	62	11	this	this	DET
admet-2043	62	12	domain	domain	NOUN
admet-2043	62	13	holds	hold	VERB
admet-2043	62	14	promise	promise	NOUN
admet-2043	62	15	and	and	CCONJ
admet-2043	62	16	may	may	AUX
admet-2043	62	17	signify	signify	VERB
admet-2043	62	18	a	a	DET
admet-2043	62	19	significant	significant	ADJ
admet-2043	62	20	advancement	advancement	NOUN
admet-2043	62	21	in	in	ADP
admet-2043	62	22	the	the	DET
admet-2043	62	23	field	field	NOUN
admet-2043	62	24	.	.	PUNCT
admet-2043	63	1	an	an	DET
admet-2043	63	2	intriguing	intriguing	ADJ
admet-2043	63	3	non	non	ADJ
admet-2043	63	4	-	-	ADJ
admet-2043	63	5	invasive	invasive	ADJ
admet-2043	63	6	alternative	alternative	NOUN
admet-2043	63	7	is	be	AUX
admet-2043	63	8	intranasal	intranasal	ADJ
admet-2043	63	9	drug	drug	NOUN
admet-2043	63	10	administration	administration	NOUN
admet-2043	63	11	,	,	PUNCT
admet-2043	63	12	which	which	PRON
admet-2043	63	13	has	have	AUX
admet-2043	63	14	attracted	attract	VERB
admet-2043	63	15	considerable	considerable	ADJ
admet-2043	63	16	interest	interest	NOUN
admet-2043	63	17	among	among	ADP
admet-2043	63	18	researchers	researcher	NOUN
admet-2043	63	19	.	.	PUNCT
admet-2043	64	1	although	although	SCONJ
admet-2043	64	2	it	it	PRON
admet-2043	64	3	has	have	VERB
admet-2043	64	4	challenges	challenge	NOUN
admet-2043	64	5	,	,	PUNCT
admet-2043	64	6	notably	notably	ADV
admet-2043	64	7	in	in	ADP
admet-2043	64	8	maintaining	maintain	VERB
admet-2043	64	9	consistent	consistent	ADJ
admet-2043	64	10	dosages	dosage	NOUN
admet-2043	64	11	,	,	PUNCT
admet-2043	64	12	the	the	DET
admet-2043	64	13	potential	potential	NOUN
admet-2043	64	14	for	for	ADP
admet-2043	64	15	delivering	deliver	VERB
admet-2043	64	16	drugs	drug	NOUN
admet-2043	64	17	to	to	ADP
admet-2043	64	18	the	the	DET
admet-2043	64	19	cns	cns	NOUN
admet-2043	64	20	through	through	ADP
admet-2043	64	21	this	this	DET
admet-2043	64	22	route	route	NOUN
admet-2043	64	23	is	be	AUX
admet-2043	64	24	notable	notable	ADJ
admet-2043	64	25	.	.	PUNCT
admet-2043	65	1	one	one	NUM
admet-2043	65	2	key	key	ADJ
admet-2043	65	3	area	area	NOUN
admet-2043	65	4	of	of	ADP
admet-2043	65	5	interest	interest	NOUN
admet-2043	65	6	is	be	AUX
admet-2043	65	7	the	the	DET
admet-2043	65	8	utilization	utilization	NOUN
admet-2043	65	9	of	of	ADP
admet-2043	65	10	nanoparticles	nanoparticle	NOUN
admet-2043	65	11	to	to	PART
admet-2043	65	12	overcome	overcome	VERB
admet-2043	65	13	the	the	DET
admet-2043	65	14	bbb	bbb	PROPN
admet-2043	65	15	limitations	limitation	NOUN
admet-2043	65	16	.	.	PUNCT
admet-2043	66	1	modifying	modify	VERB
admet-2043	66	2	drug	drug	NOUN
admet-2043	66	3	molecular	molecular	ADJ
admet-2043	66	4	structures	structure	NOUN
admet-2043	66	5	or	or	CCONJ
admet-2043	66	6	employing	employ	VERB
admet-2043	66	7	prodrug	prodrug	NOUN
admet-2043	66	8	strategies	strategy	NOUN
admet-2043	66	9	,	,	PUNCT
admet-2043	66	10	as	as	SCONJ
admet-2043	66	11	demonstrated	demonstrate	VERB
admet-2043	66	12	by	by	ADP
admet-2043	66	13	levodopa	levodopa	NOUN
admet-2043	66	14	,	,	PUNCT
admet-2043	66	15	offers	offer	VERB
admet-2043	66	16	exciting	exciting	ADJ
admet-2043	66	17	potential	potential	NOUN
admet-2043	66	18	for	for	ADP
admet-2043	66	19	improving	improve	VERB
admet-2043	66	20	drug	drug	NOUN
admet-2043	66	21	delivery	delivery	NOUN
admet-2043	66	22	to	to	ADP
admet-2043	66	23	the	the	DET
admet-2043	66	24	brain	brain	NOUN
admet-2043	66	25	.	.	PUNCT
admet-2043	67	1	however	however	ADV
admet-2043	67	2	,	,	PUNCT
admet-2043	67	3	it	it	PRON
admet-2043	67	4	's	be	AUX
admet-2043	67	5	essential	essential	ADJ
admet-2043	67	6	to	to	PART
admet-2043	67	7	recognize	recognize	VERB
admet-2043	67	8	the	the	DET
admet-2043	67	9	constraints	constraint	NOUN
admet-2043	67	10	and	and	CCONJ
admet-2043	67	11	potential	potential	ADJ
admet-2043	67	12	risks	risk	NOUN
admet-2043	67	13	associated	associate	VERB
admet-2043	67	14	with	with	ADP
admet-2043	67	15	these	these	DET
admet-2043	67	16	strategies	strategy	NOUN
admet-2043	67	17	,	,	PUNCT
admet-2043	67	18	particularly	particularly	ADV
admet-2043	67	19	in	in	ADP
admet-2043	67	20	terms	term	NOUN
admet-2043	67	21	of	of	ADP
admet-2043	67	22	the	the	DET
admet-2043	67	23	bbb	bbb	PROPN
admet-2043	67	24	's	's	PART
admet-2043	67	25	protective	protective	ADJ
admet-2043	67	26	function	function	NOUN
admet-2043	67	27	for	for	ADP
admet-2043	67	28	the	the	DET
admet-2043	67	29	brain	brain	NOUN
admet-2043	67	30	.	.	PUNCT
admet-2043	68	1	additionally	additionally	ADV
admet-2043	68	2	,	,	PUNCT
admet-2043	68	3	considering	consider	VERB
admet-2043	68	4	reversible	reversible	ADJ
admet-2043	68	5	disruption	disruption	NOUN
admet-2043	68	6	of	of	ADP
admet-2043	68	7	the	the	DET
admet-2043	68	8	bbb	bbb	NOUN
admet-2043	68	9	using	use	VERB
admet-2043	68	10	agents	agent	NOUN
admet-2043	68	11	like	like	ADP
admet-2043	68	12	mannitol	mannitol	NOUN
admet-2043	68	13	injection	injection	NOUN
admet-2043	68	14	or	or	CCONJ
admet-2043	68	15	physical	physical	ADJ
admet-2043	68	16	methodologies	methodology	NOUN
admet-2043	68	17	such	such	ADJ
admet-2043	68	18	as	as	ADP
admet-2043	68	19	ultrasound	ultrasound	NOUN
admet-2043	68	20	represents	represent	VERB
admet-2043	68	21	an	an	DET
admet-2043	68	22	intriguing	intriguing	ADJ
admet-2043	68	23	direction	direction	NOUN
admet-2043	68	24	for	for	ADP
admet-2043	68	25	research	research	NOUN
admet-2043	68	26	.	.	PUNCT
admet-2043	69	1	nonetheless	nonetheless	ADV
admet-2043	69	2	,	,	PUNCT
admet-2043	69	3	the	the	DET
admet-2043	69	4	balance	balance	NOUN
admet-2043	69	5	between	between	ADP
admet-2043	69	6	enhancing	enhance	VERB
admet-2043	69	7	drug	drug	NOUN
admet-2043	69	8	delivery	delivery	NOUN
admet-2043	69	9	and	and	CCONJ
admet-2043	69	10	preserving	preserve	VERB
admet-2043	69	11	the	the	DET
admet-2043	69	12	bbb	bbb	NOUN
admet-2043	69	13	's	's	PART
admet-2043	69	14	protective	protective	ADJ
admet-2043	69	15	role	role	NOUN
admet-2043	69	16	is	be	AUX
admet-2043	69	17	a	a	DET
admet-2043	69	18	critical	critical	ADJ
admet-2043	69	19	consideration	consideration	NOUN
admet-2043	69	20	in	in	ADP
admet-2043	69	21	pursuing	pursue	VERB
admet-2043	69	22	innovation	innovation	NOUN
admet-2043	69	23	within	within	ADP
admet-2043	69	24	the	the	DET
admet-2043	69	25	field	field	NOUN
admet-2043	69	26	.	.	PUNCT
admet-2043	70	1	anatomy	anatomy	NOUN
admet-2043	70	2	of	of	ADP
admet-2043	70	3	bbb	bbb	PROPN
admet-2043	70	4	structure	structure	NOUN
admet-2043	70	5	and	and	CCONJ
admet-2043	70	6	composition	composition	NOUN
admet-2043	70	7	of	of	ADP
admet-2043	70	8	bbb	bbb	PROPN
admet-2043	70	9	bbb	bbb	PROPN
admet-2043	70	10	is	be	AUX
admet-2043	70	11	comprised	comprise	VERB
admet-2043	70	12	of	of	ADP
admet-2043	70	13	various	various	ADJ
admet-2043	70	14	cellular	cellular	ADJ
admet-2043	70	15	components	component	NOUN
admet-2043	70	16	,	,	PUNCT
admet-2043	70	17	including	include	VERB
admet-2043	70	18	endothelial	endothelial	ADJ
admet-2043	70	19	cells	cell	NOUN
admet-2043	70	20	(	(	PUNCT
admet-2043	70	21	ecs	ecs	PROPN
admet-2043	70	22	)	)	PUNCT
admet-2043	70	23	,	,	PUNCT
admet-2043	70	24	tight	tight	ADJ
admet-2043	70	25	junctions	junction	NOUN
admet-2043	70	26	(	(	PUNCT
admet-2043	70	27	tjs	tjs	NOUN
admet-2043	70	28	)	)	PUNCT
admet-2043	70	29	,	,	PUNCT
admet-2043	70	30	and	and	CCONJ
admet-2043	70	31	adherent	adherent	ADJ
admet-2043	70	32	junctions	junction	NOUN
admet-2043	70	33	(	(	PUNCT
admet-2043	70	34	ajs	ajs	PROPN
admet-2043	70	35	)	)	PUNCT
admet-2043	70	36	.	.	PUNCT
admet-2043	71	1	these	these	DET
admet-2043	71	2	components	component	NOUN
admet-2043	71	3	regulate	regulate	VERB
admet-2043	71	4	and	and	CCONJ
admet-2043	71	5	facilitate	facilitate	VERB
admet-2043	71	6	the	the	DET
admet-2043	71	7	emergence	emergence	NOUN
admet-2043	71	8	and	and	CCONJ
admet-2043	71	9	maintenance	maintenance	NOUN
admet-2043	71	10	of	of	ADP
admet-2043	71	11	the	the	DET
admet-2043	71	12	bbb	bbb	NOUN
admet-2043	71	13	through	through	ADP
admet-2043	71	14	the	the	DET
admet-2043	71	15	control	control	NOUN
admet-2043	71	16	of	of	ADP
admet-2043	71	17	ec	ec	PROPN
admet-2043	71	18	proliferation	proliferation	NOUN
admet-2043	71	19	,	,	PUNCT
admet-2043	71	20	migration	migration	NOUN
admet-2043	71	21	,	,	PUNCT
admet-2043	71	22	and	and	CCONJ
admet-2043	71	23	vascular	vascular	ADJ
admet-2043	71	24	branching	branching	NOUN
admet-2043	71	25	within	within	ADP
admet-2043	71	26	the	the	DET
admet-2043	71	27	brain	brain	NOUN
admet-2043	71	28	.	.	PUNCT
admet-2043	72	1	the	the	DET
admet-2043	72	2	extracellular	extracellular	ADJ
admet-2043	72	3	matrix	matrix	NOUN
admet-2043	72	4	,	,	PUNCT
admet-2043	72	5	known	know	VERB
admet-2043	72	6	as	as	ADP
admet-2043	72	7	the	the	DET
admet-2043	72	8	basement	basement	NOUN
admet-2043	72	9	membrane	membrane	NOUN
admet-2043	72	10	,	,	PUNCT
admet-2043	72	11	is	be	AUX
admet-2043	72	12	essential	essential	ADJ
admet-2043	72	13	for	for	ADP
admet-2043	72	14	providing	provide	VERB
admet-2043	72	15	structural	structural	ADJ
admet-2043	72	16	support	support	NOUN
admet-2043	72	17	in	in	ADP
admet-2043	72	18	the	the	DET
admet-2043	72	19	vicinity	vicinity	NOUN
admet-2043	72	20	of	of	ADP
admet-2043	72	21	pericytes	pericyte	NOUN
admet-2043	72	22	and	and	CCONJ
admet-2043	72	23	endothelial	endothelial	ADJ
admet-2043	72	24	cells	cell	NOUN
admet-2043	72	25	.	.	PUNCT
admet-2043	73	1	the	the	DET
admet-2043	73	2	basal	basal	ADJ
admet-2043	73	3	lamina	lamina	NOUN
admet-2043	73	4	exhibits	exhibit	VERB
admet-2043	73	5	continuity	continuity	NOUN
admet-2043	73	6	with	with	ADP
admet-2043	73	7	the	the	DET
admet-2043	73	8	plasma	plasma	NOUN
admet-2043	73	9	membrane	membrane	NOUN
admet-2043	73	10	of	of	ADP
admet-2043	73	11	the	the	DET
admet-2043	73	12	astrocyte	astrocyte	NOUN
admet-2043	73	13	end	end	NOUN
admet-2043	73	14	-	-	PUNCT
admet-2043	73	15	feet	foot	NOUN
admet-2043	73	16	[	[	X
admet-2043	73	17	14	14	NUM
admet-2043	73	18	]	]	PUNCT
admet-2043	73	19	.	.	PUNCT
admet-2043	74	1	endothelial	endothelial	ADJ
admet-2043	74	2	cells	cell	NOUN
admet-2043	74	3	(	(	PUNCT
admet-2043	74	4	ecs	ec	NOUN
admet-2043	74	5	)	)	PUNCT
admet-2043	74	6	the	the	DET
admet-2043	74	7	mitochondrial	mitochondrial	ADJ
admet-2043	74	8	content	content	NOUN
admet-2043	74	9	of	of	ADP
admet-2043	74	10	bbb	bbb	PROPN
admet-2043	74	11	ecs	ecs	PROPN
admet-2043	74	12	is	be	AUX
admet-2043	74	13	comparatively	comparatively	ADV
admet-2043	74	14	higher	high	ADJ
admet-2043	74	15	than	than	ADP
admet-2043	74	16	that	that	PRON
admet-2043	74	17	of	of	ADP
admet-2043	74	18	the	the	DET
admet-2043	74	19	peripheral	peripheral	ADJ
admet-2043	74	20	vasculature	vasculature	NOUN
admet-2043	74	21	.	.	PUNCT
admet-2043	75	1	these	these	DET
admet-2043	75	2	cells	cell	NOUN
admet-2043	75	3	also	also	ADV
admet-2043	75	4	display	display	VERB
admet-2043	75	5	minimal	minimal	ADJ
admet-2043	75	6	pinocytic	pinocytic	ADJ
admet-2043	75	7	activity	activity	NOUN
admet-2043	75	8	and	and	CCONJ
admet-2043	75	9	are	be	AUX
admet-2043	75	10	devoid	devoid	ADJ
admet-2043	75	11	of	of	ADP
admet-2043	75	12	fenestrations	fenestration	NOUN
admet-2043	75	13	.	.	PUNCT
admet-2043	76	1	the	the	DET
admet-2043	76	2	limited	limited	ADJ
admet-2043	76	3	paracellular	paracellular	ADJ
admet-2043	76	4	permeability	permeability	NOUN
admet-2043	76	5	of	of	ADP
admet-2043	76	6	the	the	DET
admet-2043	76	7	endothelial	endothelial	ADJ
admet-2043	76	8	cell	cell	NOUN
admet-2043	76	9	layer	layer	NOUN
admet-2043	76	10	is	be	AUX
admet-2043	76	11	justified	justify	VERB
admet-2043	76	12	due	due	ADP
admet-2043	76	13	to	to	ADP
admet-2043	76	14	the	the	DET
admet-2043	76	15	presence	presence	NOUN
admet-2043	76	16	of	of	ADP
admet-2043	76	17	two	two	NUM
admet-2043	76	18	intercellular	intercellular	ADJ
admet-2043	76	19	molecular	molecular	ADJ
admet-2043	76	20	binding	bind	VERB
admet-2043	76	21	mechanisms	mechanism	NOUN
admet-2043	76	22	.	.	PUNCT
admet-2043	77	1	the	the	DET
admet-2043	77	2	present	present	ADJ
admet-2043	77	3	study	study	NOUN
admet-2043	77	4	aims	aim	VERB
admet-2043	77	5	to	to	PART
admet-2043	77	6	investigate	investigate	VERB
admet-2043	77	7	the	the	DET
admet-2043	77	8	potential	potential	ADJ
admet-2043	77	9	relationship	relationship	NOUN
admet-2043	77	10	between	between	ADP
admet-2043	77	11	tjs	tjs	NOUN
admet-2043	77	12	and	and	CCONJ
admet-2043	77	13	ajs	ajs	PROPN
admet-2043	77	14	[	[	X
admet-2043	77	15	15	15	NUM
admet-2043	77	16	]	]	PUNCT
admet-2043	77	17	.	.	PUNCT
admet-2043	78	1	astrocytes	astrocyte	NOUN
admet-2043	78	2	astrocytes	astrocytes	PROPN
admet-2043	78	3	,	,	PUNCT
admet-2043	78	4	an	an	DET
admet-2043	78	5	assortment	assortment	NOUN
admet-2043	78	6	of	of	ADP
admet-2043	78	7	glial	glial	ADJ
admet-2043	78	8	cells	cell	NOUN
admet-2043	78	9	,	,	PUNCT
admet-2043	78	10	are	be	AUX
admet-2043	78	11	imperative	imperative	ADJ
admet-2043	78	12	in	in	ADP
admet-2043	78	13	the	the	DET
admet-2043	78	14	upkeep	upkeep	NOUN
admet-2043	78	15	and	and	CCONJ
admet-2043	78	16	safety	safety	NOUN
admet-2043	78	17	of	of	ADP
admet-2043	78	18	neurons	neuron	NOUN
admet-2043	78	19	.	.	PUNCT
admet-2043	79	1	they	they	PRON
admet-2043	79	2	achieve	achieve	VERB
admet-2043	79	3	this	this	PRON
admet-2043	79	4	by	by	ADP
admet-2043	79	5	regulating	regulate	VERB
admet-2043	79	6	neurotransmitter	neurotransmitter	NOUN
admet-2043	79	7	and	and	CCONJ
admet-2043	79	8	ion	ion	NOUN
admet-2043	79	9	concentrations	concentration	NOUN
admet-2043	79	10	,	,	PUNCT
admet-2043	79	11	which	which	PRON
admet-2043	79	12	helps	help	VERB
admet-2043	79	13	to	to	PART
admet-2043	79	14	maintain	maintain	VERB
admet-2043	79	15	the	the	DET
admet-2043	79	16	homeostatic	homeostatic	ADJ
admet-2043	79	17	balance	balance	NOUN
admet-2043	79	18	of	of	ADP
admet-2043	79	19	the	the	DET
admet-2043	79	20	neural	neural	ADJ
admet-2043	79	21	microenvironment	microenvironment	NOUN
admet-2043	79	22	.	.	PUNCT
admet-2043	80	1	additionally	additionally	ADV
admet-2043	80	2	,	,	PUNCT
admet-2043	80	3	astrocytes	astrocyte	NOUN
admet-2043	80	4	modulate	modulate	VERB
admet-2043	80	5	synaptic	synaptic	ADJ
admet-2043	80	6	transmission	transmission	NOUN
admet-2043	80	7	and	and	CCONJ
admet-2043	80	8	regulate	regulate	VERB
admet-2043	80	9	immune	immune	ADJ
admet-2043	80	10	reactions	reaction	NOUN
admet-2043	80	11	,	,	PUNCT
admet-2043	80	12	further	far	ADV
admet-2043	80	13	contributing	contribute	VERB
admet-2043	80	14	to	to	ADP
admet-2043	80	15	their	their	PRON
admet-2043	80	16	important	important	ADJ
admet-2043	80	17	role	role	NOUN
admet-2043	80	18	in	in	ADP
admet-2043	80	19	neural	neural	ADJ
admet-2043	80	20	function	function	NOUN
admet-2043	81	1	[	[	X
admet-2043	81	2	16	16	NUM
admet-2043	81	3	]	]	PUNCT
admet-2043	81	4	by	by	ADP
admet-2043	81	5	interacting	interact	VERB
admet-2043	81	6	with	with	ADP
admet-2043	81	7	endothelial	endothelial	ADJ
admet-2043	81	8	cells	cell	NOUN
admet-2043	81	9	through	through	ADP
admet-2043	81	10	their	their	PRON
admet-2043	81	11	end	end	NOUN
admet-2043	81	12	feet	foot	NOUN
admet-2043	81	13	projections	projection	NOUN
admet-2043	81	14	that	that	PRON
admet-2043	81	15	encircle	encircle	VERB
admet-2043	81	16	the	the	DET
admet-2043	81	17	basolateral	basolateral	ADJ
admet-2043	81	18	side	side	NOUN
admet-2043	81	19	of	of	ADP
admet-2043	81	20	cerebral	cerebral	ADJ
admet-2043	81	21	capillaries	capillary	NOUN
admet-2043	81	22	,	,	PUNCT
admet-2043	81	23	admet	admet	PROPN
admet-2043	81	24	&	&	CCONJ
admet-2043	81	25	dmpk	dmpk	PROPN
admet-2043	81	26	12(1	12(1	PROPN
admet-2043	81	27	)	)	PUNCT
admet-2043	81	28	(	(	PUNCT
admet-2043	81	29	2024	2024	NUM
admet-2043	81	30	)	)	PUNCT
admet-2043	81	31	63	63	NUM
admet-2043	81	32	-	-	SYM
admet-2043	81	33	105	105	NUM
admet-2043	81	34	nanomaterials	nanomaterial	NOUN
admet-2043	81	35	as	as	ADP
admet-2043	81	36	drug	drug	NOUN
admet-2043	81	37	delivery	delivery	NOUN
admet-2043	81	38	agents	agent	NOUN
admet-2043	81	39	for	for	ADP
admet-2043	81	40	overcoming	overcome	VERB
admet-2043	81	41	bbb	bbb	PROPN
admet-2043	81	42	doi	doi	NOUN
admet-2043	81	43	:	:	PUNCT
admet-2043	81	44	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	81	45	67	67	NUM
admet-2043	81	46	astrocytes	astrocyte	NOUN
admet-2043	81	47	exhibit	exhibit	VERB
admet-2043	81	48	a	a	DET
admet-2043	81	49	profusion	profusion	NOUN
admet-2043	81	50	of	of	ADP
admet-2043	81	51	slender	slender	ADJ
admet-2043	81	52	projections	projection	NOUN
admet-2043	81	53	that	that	SCONJ
admet-2043	81	54	sheath	sheath	NOUN
admet-2043	81	55	cerebral	cerebral	ADJ
admet-2043	81	56	vasculature	vasculature	NOUN
admet-2043	81	57	and	and	CCONJ
admet-2043	81	58	enwrap	enwrap	VERB
admet-2043	81	59	both	both	PRON
admet-2043	81	60	individual	individual	ADJ
admet-2043	81	61	and	and	CCONJ
admet-2043	81	62	clustered	clustered	ADJ
admet-2043	81	63	synaptic	synaptic	ADJ
admet-2043	81	64	junctions	junction	NOUN
admet-2043	81	65	[	[	X
admet-2043	81	66	17	17	NUM
admet-2043	81	67	]	]	PUNCT
admet-2043	81	68	astrocytes	astrocyte	NOUN
admet-2043	81	69	are	be	AUX
admet-2043	81	70	the	the	DET
admet-2043	81	71	predominant	predominant	ADJ
admet-2043	81	72	cell	cell	NOUN
admet-2043	81	73	type	type	NOUN
admet-2043	81	74	found	find	VERB
admet-2043	81	75	in	in	ADP
admet-2043	81	76	the	the	DET
admet-2043	81	77	cns	cns	NOUN
admet-2043	81	78	and	and	CCONJ
admet-2043	81	79	are	be	AUX
admet-2043	81	80	known	know	VERB
admet-2043	81	81	to	to	PART
admet-2043	81	82	participate	participate	VERB
admet-2043	81	83	in	in	ADP
admet-2043	81	84	a	a	DET
admet-2043	81	85	variety	variety	NOUN
admet-2043	81	86	of	of	ADP
admet-2043	81	87	physiological	physiological	ADJ
admet-2043	81	88	and	and	CCONJ
admet-2043	81	89	biochemical	biochemical	ADJ
admet-2043	81	90	processes	process	NOUN
admet-2043	81	91	[	[	X
admet-2043	81	92	18	18	NUM
admet-2043	81	93	]	]	PUNCT
admet-2043	81	94	.	.	PUNCT
admet-2043	82	1	the	the	DET
admet-2043	82	2	functions	function	NOUN
admet-2043	82	3	mentioned	mention	VERB
admet-2043	82	4	earlier	early	ADV
admet-2043	82	5	encompass	encompass	NOUN
admet-2043	82	6	(	(	PUNCT
admet-2043	82	7	1	1	X
admet-2043	82	8	)	)	PUNCT
admet-2043	82	9	the	the	DET
admet-2043	82	10	emergence	emergence	NOUN
admet-2043	82	11	of	of	ADP
admet-2043	82	12	distinct	distinct	ADJ
admet-2043	82	13	compartments	compartment	NOUN
admet-2043	82	14	within	within	ADP
admet-2043	82	15	the	the	DET
admet-2043	82	16	parenchyma	parenchyma	NOUN
admet-2043	82	17	,	,	PUNCT
admet-2043	82	18	(	(	PUNCT
admet-2043	82	19	2	2	X
admet-2043	82	20	)	)	PUNCT
admet-2043	82	21	the	the	DET
admet-2043	82	22	preservation	preservation	NOUN
admet-2043	82	23	of	of	ADP
admet-2043	82	24	extracellular	extracellular	ADJ
admet-2043	82	25	ionic	ionic	ADJ
admet-2043	82	26	homeostasis	homeostasis	NOUN
admet-2043	82	27	,	,	PUNCT
admet-2043	82	28	(	(	PUNCT
admet-2043	82	29	3	3	X
admet-2043	82	30	)	)	PUNCT
admet-2043	82	31	regulation	regulation	NOUN
admet-2043	82	32	of	of	ADP
admet-2043	82	33	ph	ph	NOUN
admet-2043	82	34	,	,	PUNCT
admet-2043	82	35	(	(	PUNCT
admet-2043	82	36	4	4	X
admet-2043	82	37	)	)	PUNCT
admet-2043	82	38	the	the	DET
admet-2043	82	39	facilitation	facilitation	NOUN
admet-2043	82	40	of	of	ADP
admet-2043	82	41	uptake	uptake	NOUN
admet-2043	82	42	of	of	ADP
admet-2043	82	43	neurotransmitters	neurotransmitter	NOUN
admet-2043	82	44	,	,	PUNCT
admet-2043	82	45	and	and	CCONJ
admet-2043	82	46	(	(	PUNCT
admet-2043	82	47	5	5	X
admet-2043	82	48	)	)	PUNCT
admet-2043	82	49	the	the	DET
admet-2043	82	50	mediation	mediation	NOUN
admet-2043	82	51	of	of	ADP
admet-2043	82	52	neuronal	neuronal	ADJ
admet-2043	82	53	signals	signal	NOUN
admet-2043	82	54	to	to	ADP
admet-2043	82	55	the	the	DET
admet-2043	82	56	vasculature	vasculature	NOUN
admet-2043	82	57	.	.	PUNCT
admet-2043	83	1	pericytes	pericyte	NOUN
admet-2043	83	2	while	while	SCONJ
admet-2043	83	3	eberth	eberth	ADV
admet-2043	83	4	initially	initially	ADV
admet-2043	83	5	reported	report	VERB
admet-2043	83	6	their	their	PRON
admet-2043	83	7	existence	existence	NOUN
admet-2043	83	8	in	in	ADP
admet-2043	83	9	1871	1871	NUM
admet-2043	83	10	,	,	PUNCT
admet-2043	83	11	the	the	DET
admet-2043	83	12	credit	credit	NOUN
admet-2043	83	13	for	for	ADP
admet-2043	83	14	the	the	DET
admet-2043	83	15	discovery	discovery	NOUN
admet-2043	83	16	of	of	ADP
admet-2043	83	17	pericytes	pericyte	NOUN
admet-2043	83	18	is	be	AUX
admet-2043	83	19	generally	generally	ADV
admet-2043	83	20	attributed	attribute	VERB
admet-2043	83	21	to	to	ADP
admet-2043	83	22	charles	charles	PROPN
admet-2043	83	23	-	-	PUNCT
admet-2043	83	24	marie	marie	PROPN
admet-2043	83	25	benjamin	benjamin	PROPN
admet-2043	83	26	rouget	rouget	PROPN
admet-2043	83	27	,	,	PUNCT
admet-2043	83	28	a	a	DET
admet-2043	83	29	french	french	ADJ
admet-2043	83	30	researcher	researcher	NOUN
admet-2043	83	31	who	who	PRON
admet-2043	83	32	,	,	PUNCT
admet-2043	83	33	two	two	NUM
admet-2043	83	34	years	year	NOUN
admet-2043	83	35	later	later	ADV
admet-2043	83	36	,	,	PUNCT
admet-2043	83	37	identified	identify	VERB
admet-2043	83	38	a	a	DET
admet-2043	83	39	group	group	NOUN
admet-2043	83	40	of	of	ADP
admet-2043	83	41	contractile	contractile	NOUN
admet-2043	83	42	cells	cell	NOUN
admet-2043	83	43	that	that	PRON
admet-2043	83	44	encircle	encircle	VERB
admet-2043	83	45	the	the	DET
admet-2043	83	46	endothelial	endothelial	ADJ
admet-2043	83	47	cells	cell	NOUN
admet-2043	83	48	of	of	ADP
admet-2043	83	49	minor	minor	ADJ
admet-2043	83	50	blood	blood	NOUN
admet-2043	83	51	vessels	vessel	NOUN
admet-2043	83	52	.	.	PUNCT
admet-2043	84	1	pericytes	pericyte	NOUN
admet-2043	84	2	,	,	PUNCT
admet-2043	84	3	also	also	ADV
admet-2043	84	4	referred	refer	VERB
admet-2043	84	5	to	to	ADP
admet-2043	84	6	as	as	ADP
admet-2043	84	7	rouget	rouget	VERB
admet-2043	84	8	cells	cell	NOUN
admet-2043	84	9	or	or	CCONJ
admet-2043	84	10	mural	mural	ADJ
admet-2043	84	11	cells	cell	NOUN
admet-2043	84	12	,	,	PUNCT
admet-2043	84	13	have	have	AUX
admet-2043	84	14	been	be	AUX
admet-2043	84	15	observed	observe	VERB
admet-2043	84	16	to	to	PART
admet-2043	84	17	be	be	AUX
admet-2043	84	18	present	present	ADJ
admet-2043	84	19	in	in	ADP
admet-2043	84	20	nearly	nearly	ADV
admet-2043	84	21	all	all	PRON
admet-2043	84	22	capillaries	capillary	NOUN
admet-2043	84	23	,	,	PUNCT
admet-2043	84	24	in	in	ADP
admet-2043	84	25	addition	addition	NOUN
admet-2043	84	26	to	to	ADP
admet-2043	84	27	small	small	ADJ
admet-2043	84	28	arterioles	arteriole	NOUN
admet-2043	84	29	and	and	CCONJ
admet-2043	84	30	venules	venule	NOUN
admet-2043	84	31	.	.	PUNCT
admet-2043	85	1	the	the	DET
admet-2043	85	2	aforementioned	aforementioned	ADJ
admet-2043	85	3	entities	entity	NOUN
admet-2043	85	4	are	be	AUX
admet-2043	85	5	diminutive	diminutive	ADJ
admet-2043	85	6	cellular	cellular	ADJ
admet-2043	85	7	structures	structure	NOUN
admet-2043	85	8	in	in	ADP
admet-2043	85	9	the	the	DET
admet-2043	85	10	extravascular	extravascular	ADJ
admet-2043	85	11	space	space	NOUN
admet-2043	85	12	,	,	PUNCT
admet-2043	85	13	interposed	interpose	VERB
admet-2043	85	14	amidst	amidst	ADP
admet-2043	85	15	the	the	DET
admet-2043	85	16	endothelial	endothelial	ADJ
admet-2043	85	17	monolayer	monolayer	NOUN
admet-2043	85	18	and	and	CCONJ
admet-2043	85	19	the	the	DET
admet-2043	85	20	parenchymal	parenchymal	ADJ
admet-2043	85	21	tissue	tissue	NOUN
admet-2043	85	22	.	.	PUNCT
admet-2043	86	1	the	the	DET
admet-2043	86	2	basal	basal	ADJ
admet-2043	86	3	lamina	lamina	NOUN
admet-2043	86	4	serves	serve	VERB
admet-2043	86	5	as	as	ADP
admet-2043	86	6	a	a	DET
admet-2043	86	7	partition	partition	NOUN
admet-2043	86	8	between	between	ADP
admet-2043	86	9	the	the	DET
admet-2043	86	10	parenchyma	parenchyma	NOUN
admet-2043	86	11	and	and	CCONJ
admet-2043	86	12	the	the	DET
admet-2043	86	13	pericyte	pericyte	NOUN
admet-2043	86	14	and	and	CCONJ
admet-2043	86	15	endothelial	endothelial	ADJ
admet-2043	86	16	cells	cell	NOUN
admet-2043	86	17	.	.	PUNCT
admet-2043	87	1	the	the	DET
admet-2043	87	2	morphological	morphological	ADJ
admet-2043	87	3	characteristics	characteristic	NOUN
admet-2043	87	4	of	of	ADP
admet-2043	87	5	pericytes	pericyte	NOUN
admet-2043	87	6	exhibit	exhibit	VERB
admet-2043	87	7	variability	variability	NOUN
admet-2043	87	8	based	base	VERB
admet-2043	87	9	on	on	ADP
admet-2043	87	10	their	their	PRON
admet-2043	87	11	location	location	NOUN
admet-2043	87	12	along	along	ADP
admet-2043	87	13	the	the	DET
admet-2043	87	14	arteriovenous	arteriovenous	ADJ
admet-2043	87	15	axis	axis	NOUN
admet-2043	87	16	and	and	CCONJ
admet-2043	87	17	the	the	DET
admet-2043	87	18	vascular	vascular	ADJ
admet-2043	87	19	bed	bed	NOUN
admet-2043	87	20	.	.	PUNCT
admet-2043	88	1	typically	typically	ADV
admet-2043	88	2	,	,	PUNCT
admet-2043	88	3	pericytes	pericyte	NOUN
admet-2043	88	4	extend	extend	VERB
admet-2043	88	5	primary	primary	ADJ
admet-2043	88	6	projections	projection	NOUN
admet-2043	88	7	in	in	ADP
admet-2043	88	8	both	both	DET
admet-2043	88	9	directions	direction	NOUN
admet-2043	88	10	along	along	ADP
admet-2043	88	11	the	the	DET
admet-2043	88	12	vessel	vessel	NOUN
admet-2043	88	13	from	from	ADP
admet-2043	88	14	the	the	DET
admet-2043	88	15	soma	soma	NOUN
admet-2043	88	16	.	.	PUNCT
admet-2043	89	1	these	these	DET
admet-2043	89	2	projections	projection	NOUN
admet-2043	89	3	subsequently	subsequently	ADV
admet-2043	89	4	give	give	VERB
admet-2043	89	5	rise	rise	NOUN
admet-2043	89	6	to	to	ADP
admet-2043	89	7	secondary	secondary	ADJ
admet-2043	89	8	and	and	CCONJ
admet-2043	89	9	tertiary	tertiary	ADJ
admet-2043	89	10	processes	process	NOUN
admet-2043	89	11	that	that	PRON
admet-2043	89	12	envelop	envelop	VERB
admet-2043	89	13	the	the	DET
admet-2043	89	14	vessel	vessel	NOUN
admet-2043	89	15	[	[	X
admet-2043	89	16	19	19	NUM
admet-2043	89	17	]	]	PUNCT
admet-2043	89	18	.	.	PUNCT
admet-2043	90	1	pericytes	pericyte	NOUN
admet-2043	90	2	maintain	maintain	VERB
admet-2043	90	3	bbb	bbb	PROPN
admet-2043	90	4	integrity	integrity	NOUN
admet-2043	90	5	[	[	X
admet-2043	90	6	20	20	NUM
admet-2043	90	7	]	]	PUNCT
admet-2043	90	8	,	,	PUNCT
admet-2043	90	9	regulate	regulate	VERB
admet-2043	90	10	angiogenesis	angiogenesis	NOUN
admet-2043	90	11	(	(	PUNCT
admet-2043	90	12	microvascular	microvascular	ADJ
admet-2043	90	13	remodelling	remodelling	NOUN
admet-2043	90	14	)	)	PUNCT
admet-2043	90	15	,	,	PUNCT
admet-2043	90	16	regulate	regulate	VERB
admet-2043	90	17	phagocytosis	phagocytosis	NOUN
admet-2043	90	18	[	[	X
admet-2043	90	19	21	21	NUM
admet-2043	90	20	]	]	PUNCT
admet-2043	90	21	,	,	PUNCT
admet-2043	90	22	maintain	maintain	VERB
admet-2043	90	23	blood	blood	NOUN
admet-2043	90	24	flow	flow	NOUN
admet-2043	90	25	and	and	CCONJ
admet-2043	90	26	capillary	capillary	ADJ
admet-2043	90	27	diameter	diameter	NOUN
admet-2043	90	28	,	,	PUNCT
admet-2043	90	29	regulate	regulate	VERB
admet-2043	90	30	leukocyte	leukocyte	NOUN
admet-2043	90	31	trafficking	trafficking	NOUN
admet-2043	90	32	into	into	ADP
admet-2043	90	33	the	the	DET
admet-2043	90	34	brain	brain	NOUN
admet-2043	90	35	and	and	CCONJ
admet-2043	90	36	maintain	maintain	VERB
admet-2043	90	37	multipotent	multipotent	NOUN
admet-2043	90	38	stem	stem	NOUN
admet-2043	90	39	activity	activity	NOUN
admet-2043	90	40	.	.	PUNCT
admet-2043	91	1	pericytes	pericyte	NOUN
admet-2043	91	2	are	be	AUX
admet-2043	91	3	a	a	DET
admet-2043	91	4	crucial	crucial	ADJ
admet-2043	91	5	component	component	NOUN
admet-2043	91	6	of	of	ADP
admet-2043	91	7	the	the	DET
admet-2043	91	8	cerebral	cerebral	ADJ
admet-2043	91	9	capillary	capillary	ADJ
admet-2043	91	10	and	and	CCONJ
admet-2043	91	11	exhibit	exhibit	VERB
admet-2043	91	12	varying	vary	VERB
admet-2043	91	13	densities	density	NOUN
admet-2043	91	14	across	across	ADP
admet-2043	91	15	distinct	distinct	ADJ
admet-2043	91	16	vascular	vascular	ADJ
admet-2043	91	17	regions	region	NOUN
admet-2043	91	18	.	.	PUNCT
admet-2043	92	1	the	the	DET
admet-2043	92	2	cells	cell	NOUN
admet-2043	92	3	exhibit	exhibit	VERB
admet-2043	92	4	high	high	ADJ
admet-2043	92	5	prevalence	prevalence	NOUN
admet-2043	92	6	within	within	ADP
admet-2043	92	7	the	the	DET
admet-2043	92	8	central	central	ADJ
admet-2043	92	9	nervous	nervous	ADJ
admet-2043	92	10	system	system	NOUN
admet-2043	92	11	,	,	PUNCT
admet-2043	92	12	with	with	ADP
admet-2043	92	13	a	a	DET
admet-2043	92	14	notable	notable	ADJ
admet-2043	92	15	concentration	concentration	NOUN
admet-2043	92	16	observed	observe	VERB
admet-2043	92	17	within	within	ADP
admet-2043	92	18	the	the	DET
admet-2043	92	19	retinal	retinal	ADJ
admet-2043	92	20	tissue	tissue	NOUN
admet-2043	92	21	[	[	X
admet-2043	92	22	22	22	NUM
admet-2043	92	23	]	]	PUNCT
admet-2043	92	24	.	.	PUNCT
admet-2043	93	1	functions	function	NOUN
admet-2043	93	2	of	of	ADP
admet-2043	93	3	bbb	bbb	PROPN
admet-2043	93	4	the	the	DET
admet-2043	93	5	human	human	PROPN
admet-2043	93	6	bbb	bbb	PROPN
admet-2043	93	7	has	have	VERB
admet-2043	93	8	several	several	ADJ
admet-2043	93	9	functions	function	NOUN
admet-2043	93	10	that	that	PRON
admet-2043	93	11	are	be	AUX
admet-2043	93	12	pivotal	pivotal	ADJ
admet-2043	93	13	in	in	ADP
admet-2043	93	14	maintaining	maintain	VERB
admet-2043	93	15	neuronal	neuronal	ADJ
admet-2043	93	16	health	health	NOUN
admet-2043	93	17	.	.	PUNCT
admet-2043	94	1	the	the	DET
admet-2043	94	2	major	major	ADJ
admet-2043	94	3	functions	function	NOUN
admet-2043	94	4	have	have	AUX
admet-2043	94	5	been	be	AUX
admet-2043	94	6	explained	explain	VERB
admet-2043	94	7	below	below	ADV
admet-2043	94	8	:	:	PUNCT
admet-2043	94	9	maintaining	maintain	VERB
admet-2043	94	10	ionic	ionic	ADJ
admet-2043	94	11	homeostasis	homeostasis	NOUN
admet-2043	94	12	and	and	CCONJ
admet-2043	94	13	brain	brain	NOUN
admet-2043	94	14	nutrition	nutrition	NOUN
admet-2043	94	15	the	the	DET
admet-2043	94	16	bbb	bbb	PROPN
admet-2043	94	17	maintains	maintain	VERB
admet-2043	94	18	a	a	DET
admet-2043	94	19	regulated	regulated	ADJ
admet-2043	94	20	microenvironment	microenvironment	NOUN
admet-2043	94	21	by	by	ADP
admet-2043	94	22	means	mean	NOUN
admet-2043	94	23	of	of	ADP
admet-2043	94	24	selective	selective	ADJ
admet-2043	94	25	ion	ion	NOUN
admet-2043	94	26	channels	channel	NOUN
admet-2043	94	27	and	and	CCONJ
admet-2043	94	28	transporters	transporter	NOUN
admet-2043	94	29	that	that	PRON
admet-2043	94	30	ensure	ensure	VERB
admet-2043	94	31	the	the	DET
admet-2043	94	32	ideal	ideal	ADJ
admet-2043	94	33	ionic	ionic	ADJ
admet-2043	94	34	composition	composition	NOUN
admet-2043	94	35	for	for	ADP
admet-2043	94	36	efficient	efficient	ADJ
admet-2043	94	37	neural	neural	ADJ
admet-2043	94	38	and	and	CCONJ
admet-2043	94	39	synaptic	synaptic	ADJ
admet-2043	94	40	signalling	signal	VERB
admet-2043	94	41	processes	process	NOUN
admet-2043	94	42	.	.	PUNCT
admet-2043	95	1	the	the	DET
admet-2043	95	2	maintenance	maintenance	NOUN
admet-2043	95	3	of	of	ADP
admet-2043	95	4	potassium	potassium	NOUN
admet-2043	95	5	levels	level	NOUN
admet-2043	95	6	in	in	ADP
admet-2043	95	7	cerebrospinal	cerebrospinal	ADJ
admet-2043	95	8	fluid	fluid	NOUN
admet-2043	95	9	(	(	PUNCT
admet-2043	95	10	csf	csf	NOUN
admet-2043	95	11	)	)	PUNCT
admet-2043	95	12	and	and	CCONJ
admet-2043	95	13	interstitial	interstitial	ADJ
admet-2043	95	14	fluid	fluid	NOUN
admet-2043	95	15	(	(	PUNCT
admet-2043	95	16	isf	isf	NOUN
admet-2043	95	17	)	)	PUNCT
admet-2043	95	18	is	be	AUX
admet-2043	95	19	observed	observe	VERB
admet-2043	95	20	to	to	PART
admet-2043	95	21	be	be	AUX
admet-2043	95	22	approximately	approximately	ADV
admet-2043	95	23	2.5	2.5	NUM
admet-2043	95	24	-	-	SYM
admet-2043	95	25	2.9	2.9	NUM
admet-2043	95	26	millimolars	millimolar	NOUN
admet-2043	95	27	(	(	PUNCT
admet-2043	95	28	mm	mm	NOUN
admet-2043	95	29	)	)	PUNCT
admet-2043	95	30	.	.	PUNCT
admet-2043	96	1	the	the	DET
admet-2043	96	2	plasma	plasma	NOUN
admet-2043	96	3	concentration	concentration	NOUN
admet-2043	96	4	,	,	PUNCT
admet-2043	96	5	when	when	SCONJ
admet-2043	96	6	compared	compare	VERB
admet-2043	96	7	,	,	PUNCT
admet-2043	96	8	exhibits	exhibit	VERB
admet-2043	96	9	an	an	DET
admet-2043	96	10	approximate	approximate	ADJ
admet-2043	96	11	value	value	NOUN
admet-2043	96	12	of	of	ADP
admet-2043	96	13	4.5	4.5	NUM
admet-2043	96	14	mm	mm	NOUN
admet-2043	96	15	.	.	PUNCT
admet-2043	97	1	however	however	ADV
admet-2043	97	2	,	,	PUNCT
admet-2043	97	3	it	it	PRON
admet-2043	97	4	is	be	AUX
admet-2043	97	5	noteworthy	noteworthy	ADJ
admet-2043	97	6	that	that	SCONJ
admet-2043	97	7	fluctuations	fluctuation	NOUN
admet-2043	97	8	in	in	ADP
admet-2043	97	9	potassium	potassium	NOUN
admet-2043	97	10	plasma	plasma	NOUN
admet-2043	97	11	levels	level	NOUN
admet-2043	97	12	may	may	AUX
admet-2043	97	13	arise	arise	VERB
admet-2043	97	14	due	due	ADP
admet-2043	97	15	to	to	ADP
admet-2043	97	16	various	various	ADJ
admet-2043	97	17	factors	factor	NOUN
admet-2043	97	18	such	such	ADJ
admet-2043	97	19	as	as	ADP
admet-2043	97	20	exercise	exercise	NOUN
admet-2043	97	21	,	,	PUNCT
admet-2043	97	22	meal	meal	NOUN
admet-2043	97	23	consumption	consumption	NOUN
admet-2043	97	24	,	,	PUNCT
admet-2043	97	25	experimental	experimental	ADJ
admet-2043	97	26	imposition	imposition	NOUN
admet-2043	97	27	,	,	PUNCT
admet-2043	97	28	or	or	CCONJ
admet-2043	97	29	pathological	pathological	ADJ
admet-2043	97	30	conditions	condition	NOUN
admet-2043	97	31	[	[	X
admet-2043	97	32	23	23	NUM
admet-2043	97	33	]	]	PUNCT
admet-2043	97	34	.	.	PUNCT
admet-2043	98	1	the	the	DET
admet-2043	98	2	presence	presence	NOUN
admet-2043	98	3	of	of	ADP
admet-2043	98	4	distinct	distinct	ADJ
admet-2043	98	5	ion	ion	NOUN
admet-2043	98	6	channels	channel	NOUN
admet-2043	98	7	and	and	CCONJ
admet-2043	98	8	transporters	transporter	NOUN
admet-2043	98	9	at	at	ADP
admet-2043	98	10	the	the	DET
admet-2043	98	11	bbb	bbb	PROPN
admet-2043	98	12	creates	create	VERB
admet-2043	98	13	an	an	DET
admet-2043	98	14	ideal	ideal	ADJ
admet-2043	98	15	milieu	milieu	NOUN
admet-2043	98	16	for	for	ADP
admet-2043	98	17	the	the	DET
admet-2043	98	18	maintenance	maintenance	NOUN
admet-2043	98	19	of	of	ADP
admet-2043	98	20	synaptic	synaptic	ADJ
admet-2043	98	21	and	and	CCONJ
admet-2043	98	22	neural	neural	ADJ
admet-2043	98	23	function	function	NOUN
admet-2043	98	24	.	.	PUNCT
admet-2043	99	1	neurotransmitter	neurotransmitter	NOUN
admet-2043	99	2	level	level	NOUN
admet-2043	99	3	regulation	regulation	NOUN
admet-2043	99	4	the	the	DET
admet-2043	99	5	transportation	transportation	NOUN
admet-2043	99	6	of	of	ADP
admet-2043	99	7	neurotransmitters	neurotransmitter	NOUN
admet-2043	99	8	from	from	ADP
admet-2043	99	9	the	the	DET
admet-2043	99	10	brain	brain	NOUN
admet-2043	99	11	to	to	ADP
admet-2043	99	12	the	the	DET
admet-2043	99	13	bloodstream	bloodstream	NOUN
admet-2043	99	14	predominantly	predominantly	ADV
admet-2043	99	15	relies	rely	VERB
admet-2043	99	16	on	on	ADP
admet-2043	99	17	sodium	sodium	NOUN
admet-2043	99	18	-	-	PUNCT
admet-2043	99	19	coupled	couple	VERB
admet-2043	99	20	and	and	CCONJ
admet-2043	99	21	sodium	sodium	NOUN
admet-2043	99	22	-	-	PUNCT
admet-2043	99	23	independent	independent	ADJ
admet-2043	99	24	amino	amino	NOUN
admet-2043	99	25	acid	acid	NOUN
admet-2043	99	26	transporters	transporter	NOUN
admet-2043	99	27	.	.	PUNCT
admet-2043	100	1	the	the	DET
admet-2043	100	2	bbb	bbb	PROPN
admet-2043	100	3	restricts	restrict	VERB
admet-2043	100	4	the	the	DET
admet-2043	100	5	entry	entry	NOUN
admet-2043	100	6	of	of	ADP
admet-2043	100	7	certain	certain	ADJ
admet-2043	100	8	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	100	9	m.	m.	NOUN
admet-2043	100	10	kulkarni	kulkarni	PROPN
admet-2043	100	11	et	et	PROPN
admet-2043	100	12	al	al	PROPN
admet-2043	100	13	.	.	PROPN
admet-2043	100	14	admet	admet	PROPN
admet-2043	100	15	&	&	CCONJ
admet-2043	100	16	dmpk	dmpk	PROPN
admet-2043	100	17	12(1	12(1	PROPN
admet-2043	100	18	)	)	PUNCT
admet-2043	100	19	(	(	PUNCT
admet-2043	100	20	2024	2024	NUM
admet-2043	100	21	)	)	PUNCT
admet-2043	100	22	63	63	NUM
admet-2043	100	23	-	-	SYM
admet-2043	100	24	105	105	NUM
admet-2043	100	25	68	68	NUM
admet-2043	100	26	amino	amino	NOUN
admet-2043	100	27	acids	acid	NOUN
admet-2043	100	28	,	,	PUNCT
admet-2043	100	29	such	such	ADJ
admet-2043	100	30	as	as	ADP
admet-2043	100	31	the	the	DET
admet-2043	100	32	neurotransmitters	neurotransmitter	NOUN
admet-2043	100	33	glutamate	glutamate	VERB
admet-2043	100	34	and	and	CCONJ
admet-2043	100	35	glycine	glycine	NOUN
admet-2043	100	36	,	,	PUNCT
admet-2043	100	37	while	while	SCONJ
admet-2043	100	38	facilitating	facilitate	VERB
admet-2043	100	39	the	the	DET
admet-2043	100	40	exit	exit	NOUN
admet-2043	100	41	of	of	ADP
admet-2043	100	42	numerous	numerous	ADJ
admet-2043	100	43	other	other	ADJ
admet-2043	100	44	indispensable	indispensable	ADJ
admet-2043	100	45	amino	amino	NOUN
admet-2043	100	46	acids	acid	NOUN
admet-2043	101	1	[	[	X
admet-2043	101	2	24	24	NUM
admet-2043	101	3	]	]	PUNCT
admet-2043	101	4	.	.	PUNCT
admet-2043	102	1	prevention	prevention	NOUN
admet-2043	102	2	of	of	ADP
admet-2043	102	3	macromolecule	macromolecule	ADJ
admet-2043	102	4	entry	entry	NOUN
admet-2043	102	5	into	into	ADP
admet-2043	102	6	the	the	DET
admet-2043	102	7	human	human	ADJ
admet-2043	102	8	brain	brain	NOUN
admet-2043	102	9	under	under	ADP
admet-2043	102	10	normal	normal	ADJ
admet-2043	102	11	body	body	NOUN
admet-2043	102	12	conditions	condition	NOUN
admet-2043	102	13	,	,	PUNCT
admet-2043	102	14	the	the	DET
admet-2043	102	15	bbb	bbb	NOUN
admet-2043	102	16	prevents	prevent	VERB
admet-2043	102	17	the	the	DET
admet-2043	102	18	entry	entry	NOUN
admet-2043	102	19	of	of	ADP
admet-2043	102	20	macromolecules	macromolecule	NOUN
admet-2043	102	21	.	.	PUNCT
admet-2043	103	1	plasma	plasma	NOUN
admet-2043	103	2	proteins	protein	NOUN
admet-2043	103	3	like	like	ADP
admet-2043	103	4	albumin	albumin	NOUN
admet-2043	103	5	,	,	PUNCT
admet-2043	103	6	prothrombin	prothrombin	NOUN
admet-2043	103	7	and	and	CCONJ
admet-2043	103	8	plasminogen	plasminogen	NOUN
admet-2043	103	9	could	could	AUX
admet-2043	103	10	harm	harm	VERB
admet-2043	103	11	the	the	DET
admet-2043	103	12	nervous	nervous	ADJ
admet-2043	103	13	tissues	tissue	NOUN
admet-2043	103	14	,	,	PUNCT
admet-2043	103	15	triggering	trigger	VERB
admet-2043	103	16	cellular	cellular	ADJ
admet-2043	103	17	activation	activation	NOUN
admet-2043	103	18	,	,	PUNCT
admet-2043	103	19	which	which	PRON
admet-2043	103	20	might	might	AUX
admet-2043	103	21	lead	lead	VERB
admet-2043	103	22	to	to	AUX
admet-2043	103	23	apoptosis	apoptosis	VERB
admet-2043	103	24	.	.	PUNCT
admet-2043	104	1	there	there	PRON
admet-2043	104	2	is	be	VERB
admet-2043	104	3	an	an	DET
admet-2043	104	4	evidential	evidential	ADJ
admet-2043	104	5	presence	presence	NOUN
admet-2043	104	6	of	of	ADP
admet-2043	104	7	various	various	ADJ
admet-2043	104	8	activators	activator	NOUN
admet-2043	104	9	in	in	ADP
admet-2043	104	10	the	the	DET
admet-2043	104	11	human	human	ADJ
admet-2043	104	12	brain	brain	NOUN
admet-2043	104	13	and	and	CCONJ
admet-2043	104	14	within	within	ADP
admet-2043	104	15	the	the	DET
admet-2043	104	16	cns	cns	NOUN
admet-2043	104	17	;	;	PUNCT
admet-2043	104	18	one	one	NUM
admet-2043	104	19	of	of	ADP
admet-2043	104	20	these	these	PRON
admet-2043	104	21	is	be	AUX
admet-2043	104	22	factor	factor	NOUN
admet-2043	104	23	xa	xa	PROPN
admet-2043	104	24	.	.	PUNCT
admet-2043	105	1	factor	factor	PROPN
admet-2043	105	2	xa	xa	PROPN
admet-2043	105	3	is	be	AUX
admet-2043	105	4	responsible	responsible	ADJ
admet-2043	105	5	for	for	ADP
admet-2043	105	6	the	the	DET
admet-2043	105	7	conversion	conversion	NOUN
admet-2043	105	8	of	of	ADP
admet-2043	105	9	prothrombin	prothrombin	NOUN
admet-2043	105	10	to	to	ADP
admet-2043	105	11	thrombin	thrombin	NOUN
admet-2043	105	12	,	,	PUNCT
admet-2043	105	13	or	or	CCONJ
admet-2043	105	14	tissue	tissue	NOUN
admet-2043	105	15	plasminogen	plasminogen	NOUN
admet-2043	105	16	activator	activator	NOUN
admet-2043	105	17	,	,	PUNCT
admet-2043	105	18	which	which	PRON
admet-2043	105	19	converts	convert	VERB
admet-2043	105	20	plasminogen	plasminogen	NOUN
admet-2043	105	21	to	to	PART
admet-2043	105	22	plasmin	plasmin	PROPN
admet-2043	105	23	.	.	PUNCT
admet-2043	106	1	the	the	DET
admet-2043	106	2	resulting	result	VERB
admet-2043	106	3	proteins	protein	NOUN
admet-2043	106	4	,	,	PUNCT
admet-2043	106	5	plasmin	plasmin	NOUN
admet-2043	106	6	or	or	CCONJ
admet-2043	106	7	thrombin	thrombin	NOUN
admet-2043	106	8	,	,	PUNCT
admet-2043	106	9	can	can	AUX
admet-2043	106	10	attach	attach	VERB
admet-2043	106	11	to	to	ADP
admet-2043	106	12	their	their	PRON
admet-2043	106	13	receptors	receptor	NOUN
admet-2043	106	14	in	in	ADP
admet-2043	106	15	the	the	DET
admet-2043	106	16	human	human	ADJ
admet-2043	106	17	brain	brain	NOUN
admet-2043	106	18	tissue	tissue	NOUN
admet-2043	106	19	and	and	CCONJ
admet-2043	106	20	trigger	trigger	NOUN
admet-2043	106	21	or	or	CCONJ
admet-2043	106	22	cascade	cascade	NOUN
admet-2043	106	23	sequences	sequence	NOUN
admet-2043	106	24	of	of	ADP
admet-2043	106	25	events	event	NOUN
admet-2043	106	26	like	like	ADP
admet-2043	106	27	seizures	seizure	NOUN
admet-2043	106	28	,	,	PUNCT
admet-2043	106	29	glial	glial	ADJ
admet-2043	106	30	activation	activation	NOUN
admet-2043	106	31	,	,	PUNCT
admet-2043	106	32	glial	glial	ADJ
admet-2043	106	33	cell	cell	NOUN
admet-2043	106	34	division	division	NOUN
admet-2043	106	35	,	,	PUNCT
admet-2043	106	36	and	and	CCONJ
admet-2043	106	37	scarring	scarring	NOUN
admet-2043	106	38	followed	follow	VERB
admet-2043	106	39	by	by	ADP
admet-2043	106	40	cell	cell	NOUN
admet-2043	106	41	death	death	NOUN
admet-2043	106	42	.	.	PUNCT
admet-2043	107	1	thus	thus	ADV
admet-2043	107	2	,	,	PUNCT
admet-2043	107	3	it	it	PRON
admet-2043	107	4	is	be	AUX
admet-2043	107	5	evident	evident	ADJ
admet-2043	107	6	that	that	SCONJ
admet-2043	107	7	the	the	DET
admet-2043	107	8	bbb	bbb	PROPN
admet-2043	107	9	is	be	AUX
admet-2043	107	10	a	a	DET
admet-2043	107	11	“	"	PUNCT
admet-2043	107	12	gatekeeper	gatekeeper	NOUN
admet-2043	107	13	”	"	PUNCT
admet-2043	107	14	for	for	ADP
admet-2043	107	15	the	the	DET
admet-2043	107	16	human	human	ADJ
admet-2043	107	17	brain	brain	NOUN
admet-2043	107	18	and	and	CCONJ
admet-2043	107	19	the	the	DET
admet-2043	107	20	cns	cns	NOUN
admet-2043	107	21	system	system	NOUN
admet-2043	107	22	,	,	PUNCT
admet-2043	107	23	which	which	PRON
admet-2043	107	24	selectively	selectively	ADV
admet-2043	107	25	allows	allow	VERB
admet-2043	107	26	the	the	DET
admet-2043	107	27	entry	entry	NOUN
admet-2043	107	28	of	of	ADP
admet-2043	107	29	only	only	ADV
admet-2043	107	30	those	those	DET
admet-2043	107	31	seemingly	seemingly	ADV
admet-2043	107	32	beneficial	beneficial	ADJ
admet-2043	107	33	components	component	NOUN
admet-2043	107	34	.	.	PUNCT
admet-2043	108	1	protection	protection	NOUN
admet-2043	108	2	against	against	ADP
admet-2043	108	3	neurotoxins	neurotoxin	NOUN
admet-2043	108	4	numerous	numerous	ADJ
admet-2043	108	5	neurotoxins	neurotoxin	NOUN
admet-2043	108	6	derived	derive	VERB
admet-2043	108	7	endogenously	endogenously	ADV
admet-2043	108	8	from	from	ADP
admet-2043	108	9	metabolites	metabolite	NOUN
admet-2043	108	10	or	or	CCONJ
admet-2043	108	11	proteins	protein	NOUN
admet-2043	108	12	or	or	CCONJ
admet-2043	108	13	exogenously	exogenously	ADV
admet-2043	108	14	from	from	ADP
admet-2043	108	15	xenobiotics	xenobiotic	NOUN
admet-2043	108	16	are	be	AUX
admet-2043	108	17	often	often	ADV
admet-2043	108	18	detected	detect	VERB
admet-2043	108	19	circulating	circulate	VERB
admet-2043	108	20	in	in	ADP
admet-2043	108	21	the	the	DET
admet-2043	108	22	human	human	ADJ
admet-2043	108	23	blood	blood	NOUN
admet-2043	108	24	.	.	PUNCT
admet-2043	109	1	the	the	DET
admet-2043	109	2	atp	atp	NOUN
admet-2043	109	3	-	-	PUNCT
admet-2043	109	4	binding	bind	VERB
admet-2043	109	5	cassette	cassette	NOUN
admet-2043	109	6	(	(	PUNCT
admet-2043	109	7	abc	abc	PROPN
admet-2043	109	8	energydependent	energydependent	PROPN
admet-2043	109	9	efflux	efflux	VERB
admet-2043	109	10	transporters	transporter	NOUN
admet-2043	109	11	)	)	PUNCT
admet-2043	109	12	occupies	occupy	VERB
admet-2043	109	13	the	the	DET
admet-2043	109	14	bbb	bbb	PROPN
admet-2043	109	15	luminal	luminal	ADJ
admet-2043	109	16	surface	surface	NOUN
admet-2043	110	1	[	[	X
admet-2043	110	2	25	25	NUM
admet-2043	110	3	]	]	PUNCT
admet-2043	110	4	.	.	PUNCT
admet-2043	111	1	the	the	DET
admet-2043	111	2	cns	cns	NOUN
admet-2043	111	3	of	of	ADP
admet-2043	111	4	an	an	DET
admet-2043	111	5	adult	adult	NOUN
admet-2043	111	6	individual	individual	NOUN
admet-2043	111	7	has	have	AUX
admet-2043	111	8	limited	limit	VERB
admet-2043	111	9	regenerative	regenerative	ADJ
admet-2043	111	10	ability	ability	NOUN
admet-2043	111	11	if	if	SCONJ
admet-2043	111	12	damaged	damage	VERB
admet-2043	111	13	by	by	ADP
admet-2043	111	14	any	any	DET
admet-2043	111	15	means	mean	NOUN
admet-2043	111	16	.	.	PUNCT
admet-2043	112	1	from	from	ADP
admet-2043	112	2	the	the	DET
admet-2043	112	3	birth	birth	NOUN
admet-2043	112	4	of	of	ADP
admet-2043	112	5	the	the	DET
admet-2043	112	6	human	human	ADJ
admet-2043	112	7	being	being	NOUN
admet-2043	112	8	,	,	PUNCT
admet-2043	112	9	neuronal	neuronal	ADJ
admet-2043	112	10	cell	cell	NOUN
admet-2043	112	11	death	death	NOUN
admet-2043	112	12	is	be	AUX
admet-2043	112	13	inevitable	inevitable	ADJ
admet-2043	112	14	,	,	PUNCT
admet-2043	112	15	but	but	CCONJ
admet-2043	112	16	this	this	PRON
admet-2043	112	17	occurs	occur	VERB
admet-2043	112	18	comparatively	comparatively	ADV
admet-2043	112	19	slowly	slowly	ADV
admet-2043	112	20	.	.	PUNCT
admet-2043	113	1	the	the	DET
admet-2043	113	2	presence	presence	NOUN
admet-2043	113	3	of	of	ADP
admet-2043	113	4	neurotoxins	neurotoxin	NOUN
admet-2043	113	5	would	would	AUX
admet-2043	113	6	trigger	trigger	VERB
admet-2043	113	7	this	this	DET
admet-2043	113	8	pace	pace	NOUN
admet-2043	113	9	and	and	CCONJ
admet-2043	113	10	would	would	AUX
admet-2043	113	11	turn	turn	VERB
admet-2043	113	12	prematurely	prematurely	ADV
admet-2043	113	13	debilitating	debilitate	VERB
admet-2043	113	14	[	[	X
admet-2043	113	15	26	26	NUM
admet-2043	113	16	]	]	PUNCT
admet-2043	113	17	.	.	PUNCT
admet-2043	114	1	nanomaterials	nanomaterial	NOUN
admet-2043	114	2	for	for	ADP
admet-2043	114	3	drug	drug	NOUN
admet-2043	114	4	delivery	delivery	NOUN
admet-2043	114	5	across	across	ADP
admet-2043	114	6	bbb	bbb	PROPN
admet-2043	114	7	as	as	SCONJ
admet-2043	114	8	previously	previously	ADV
admet-2043	114	9	stated	state	VERB
admet-2043	114	10	,	,	PUNCT
admet-2043	114	11	the	the	DET
admet-2043	114	12	transportation	transportation	NOUN
admet-2043	114	13	of	of	ADP
admet-2043	114	14	drugs	drug	NOUN
admet-2043	114	15	to	to	ADP
admet-2043	114	16	the	the	DET
admet-2043	114	17	brain	brain	NOUN
admet-2043	114	18	can	can	AUX
admet-2043	114	19	be	be	AUX
admet-2043	114	20	achieved	achieve	VERB
admet-2043	114	21	through	through	ADP
admet-2043	114	22	either	either	CCONJ
admet-2043	114	23	invasive	invasive	ADJ
admet-2043	114	24	or	or	CCONJ
admet-2043	114	25	non	non	ADJ
admet-2043	114	26	-	-	ADJ
admet-2043	114	27	invasive	invasive	ADJ
admet-2043	114	28	means	mean	NOUN
admet-2043	114	29	.	.	PUNCT
admet-2043	115	1	the	the	DET
admet-2043	115	2	utilization	utilization	NOUN
admet-2043	115	3	of	of	ADP
admet-2043	115	4	nanomaterials	nanomaterial	NOUN
admet-2043	115	5	as	as	ADP
admet-2043	115	6	a	a	DET
admet-2043	115	7	drug	drug	NOUN
admet-2043	115	8	delivery	delivery	NOUN
admet-2043	115	9	system	system	NOUN
admet-2043	115	10	offers	offer	VERB
admet-2043	115	11	a	a	DET
admet-2043	115	12	versatile	versatile	ADJ
admet-2043	115	13	approach	approach	NOUN
admet-2043	115	14	to	to	ADP
admet-2043	115	15	administering	administer	VERB
admet-2043	115	16	drugs	drug	NOUN
admet-2043	115	17	,	,	PUNCT
admet-2043	115	18	as	as	SCONJ
admet-2043	115	19	the	the	DET
admet-2043	115	20	methodology	methodology	NOUN
admet-2043	115	21	can	can	AUX
admet-2043	115	22	be	be	AUX
admet-2043	115	23	tailored	tailor	VERB
admet-2043	115	24	to	to	PART
admet-2043	115	25	meet	meet	VERB
admet-2043	115	26	the	the	DET
admet-2043	115	27	specific	specific	ADJ
admet-2043	115	28	requirements	requirement	NOUN
admet-2043	115	29	of	of	ADP
admet-2043	115	30	the	the	DET
admet-2043	115	31	drug	drug	NOUN
admet-2043	115	32	delivery	delivery	NOUN
admet-2043	115	33	process	process	NOUN
admet-2043	115	34	.	.	PUNCT
admet-2043	116	1	this	this	PRON
admet-2043	116	2	involves	involve	VERB
admet-2043	116	3	designing	design	VERB
admet-2043	116	4	,	,	PUNCT
admet-2043	116	5	fabricating	fabricating	NOUN
admet-2043	116	6	,	,	PUNCT
admet-2043	116	7	and	and	CCONJ
admet-2043	116	8	characterizing	characterize	VERB
admet-2043	116	9	such	such	ADJ
admet-2043	116	10	structures	structure	NOUN
admet-2043	116	11	,	,	PUNCT
admet-2043	116	12	with	with	ADP
admet-2043	116	13	the	the	DET
admet-2043	116	14	ultimate	ultimate	ADJ
admet-2043	116	15	goal	goal	NOUN
admet-2043	116	16	of	of	ADP
admet-2043	116	17	comprehending	comprehend	VERB
admet-2043	116	18	and	and	CCONJ
admet-2043	116	19	leveraging	leverage	VERB
admet-2043	116	20	their	their	PRON
admet-2043	116	21	unique	unique	ADJ
admet-2043	116	22	properties	property	NOUN
admet-2043	116	23	and	and	CCONJ
admet-2043	116	24	functionalities	functionality	NOUN
admet-2043	116	25	.	.	PUNCT
admet-2043	117	1	nanomaterials	nanomaterial	NOUN
admet-2043	117	2	can	can	AUX
admet-2043	117	3	potentially	potentially	ADV
admet-2043	117	4	infiltrate	infiltrate	VERB
admet-2043	117	5	the	the	DET
admet-2043	117	6	human	human	ADJ
admet-2043	117	7	body	body	NOUN
admet-2043	117	8	through	through	ADP
admet-2043	117	9	various	various	ADJ
admet-2043	117	10	pathways	pathway	NOUN
admet-2043	117	11	,	,	PUNCT
admet-2043	117	12	including	include	VERB
admet-2043	117	13	the	the	DET
admet-2043	117	14	respiratory	respiratory	ADJ
admet-2043	117	15	,	,	PUNCT
admet-2043	117	16	dermal	dermal	ADJ
admet-2043	117	17	,	,	PUNCT
admet-2043	117	18	gastrointestinal	gastrointestinal	ADJ
admet-2043	117	19	,	,	PUNCT
admet-2043	117	20	and	and	CCONJ
admet-2043	117	21	parenteral	parenteral	ADJ
admet-2043	117	22	routes	route	NOUN
admet-2043	117	23	.	.	PUNCT
admet-2043	118	1	the	the	DET
admet-2043	118	2	need	need	NOUN
admet-2043	118	3	to	to	PART
admet-2043	118	4	mould	mould	AUX
admet-2043	118	5	pharmaceutical	pharmaceutical	VERB
admet-2043	118	6	active	active	ADJ
admet-2043	118	7	ingredients	ingredient	NOUN
admet-2043	118	8	into	into	ADP
admet-2043	118	9	nanomaterials	nanomaterial	NOUN
admet-2043	118	10	stems	stem	VERB
admet-2043	118	11	from	from	ADP
admet-2043	118	12	their	their	PRON
admet-2043	118	13	remarkable	remarkable	ADJ
admet-2043	118	14	capacity	capacity	NOUN
admet-2043	118	15	to	to	PART
admet-2043	118	16	encapsulate	encapsulate	VERB
admet-2043	118	17	,	,	PUNCT
admet-2043	118	18	release	release	NOUN
admet-2043	118	19	,	,	PUNCT
admet-2043	118	20	and	and	CCONJ
admet-2043	118	21	selectively	selectively	ADV
admet-2043	118	22	target	target	VERB
admet-2043	118	23	drugs	drug	NOUN
admet-2043	118	24	to	to	ADP
admet-2043	118	25	virtually	virtually	ADV
admet-2043	118	26	any	any	DET
admet-2043	118	27	organ	organ	NOUN
admet-2043	118	28	within	within	ADP
admet-2043	118	29	the	the	DET
admet-2043	118	30	body	body	NOUN
admet-2043	118	31	[	[	X
admet-2043	118	32	27	27	NUM
admet-2043	118	33	]	]	PUNCT
admet-2043	118	34	.	.	PUNCT
admet-2043	119	1	numerous	numerous	ADJ
admet-2043	119	2	investigations	investigation	NOUN
admet-2043	119	3	have	have	AUX
admet-2043	119	4	documented	document	VERB
admet-2043	119	5	the	the	DET
admet-2043	119	6	efficacious	efficacious	ADJ
admet-2043	119	7	transport	transport	NOUN
admet-2043	119	8	of	of	ADP
admet-2043	119	9	hydrophilic	hydrophilic	ADJ
admet-2043	119	10	and	and	CCONJ
admet-2043	119	11	hydrophobic	hydrophobic	NOUN
admet-2043	119	12	drugs	drug	NOUN
admet-2043	119	13	,	,	PUNCT
admet-2043	119	14	proteins	protein	NOUN
admet-2043	119	15	,	,	PUNCT
admet-2043	119	16	biological	biological	ADJ
admet-2043	119	17	macromolecules	macromolecule	NOUN
admet-2043	119	18	,	,	PUNCT
admet-2043	119	19	and	and	CCONJ
admet-2043	119	20	even	even	ADV
admet-2043	119	21	vaccines	vaccine	NOUN
admet-2043	119	22	using	use	VERB
admet-2043	119	23	nanoparticles	nanoparticle	NOUN
admet-2043	119	24	as	as	ADP
admet-2043	119	25	transport	transport	NOUN
admet-2043	119	26	systems	system	NOUN
admet-2043	119	27	[	[	X
admet-2043	119	28	28	28	NUM
admet-2043	119	29	]	]	PUNCT
admet-2043	119	30	.	.	PUNCT
admet-2043	120	1	nanoparticles	nanoparticle	NOUN
admet-2043	120	2	(	(	PUNCT
admet-2043	120	3	nps	nps	PROPN
admet-2043	120	4	)	)	PUNCT
admet-2043	120	5	possess	possess	VERB
admet-2043	120	6	the	the	DET
admet-2043	120	7	potential	potential	NOUN
admet-2043	120	8	to	to	PART
admet-2043	120	9	be	be	AUX
admet-2043	120	10	modified	modify	VERB
admet-2043	120	11	in	in	ADP
admet-2043	120	12	order	order	NOUN
admet-2043	120	13	to	to	PART
admet-2043	120	14	incorporate	incorporate	VERB
admet-2043	120	15	a	a	DET
admet-2043	120	16	range	range	NOUN
admet-2043	120	17	of	of	ADP
admet-2043	120	18	features	feature	NOUN
admet-2043	120	19	,	,	PUNCT
admet-2043	120	20	including	include	VERB
admet-2043	120	21	but	but	CCONJ
admet-2043	120	22	not	not	PART
admet-2043	120	23	limited	limit	VERB
admet-2043	120	24	to	to	ADP
admet-2043	120	25	:	:	PUNCT
admet-2043	120	26	i.	i.	PROPN
admet-2043	120	27	biocompatibility	biocompatibility	PROPN
admet-2043	120	28	,	,	PUNCT
admet-2043	120	29	ii	ii	PROPN
admet-2043	120	30	.	.	PROPN
admet-2043	121	1	reduced	reduce	VERB
admet-2043	121	2	toxicity	toxicity	NOUN
admet-2043	121	3	,	,	PUNCT
admet-2043	121	4	iii	iii	NOUN
admet-2043	121	5	.	.	PUNCT
admet-2043	122	1	the	the	DET
admet-2043	122	2	capacity	capacity	NOUN
admet-2043	122	3	to	to	PART
admet-2043	122	4	bind	bind	VERB
admet-2043	122	5	and	and	CCONJ
admet-2043	122	6	transport	transport	VERB
admet-2043	122	7	multiple	multiple	ADJ
admet-2043	122	8	loads	load	NOUN
admet-2043	122	9	,	,	PUNCT
admet-2043	122	10	iv	iv	X
admet-2043	122	11	.	.	PUNCT
admet-2043	123	1	the	the	DET
admet-2043	123	2	ability	ability	NOUN
admet-2043	123	3	to	to	PART
admet-2043	123	4	protect	protect	VERB
admet-2043	123	5	therapeutics	therapeutic	NOUN
admet-2043	123	6	from	from	ADP
admet-2043	123	7	in	in	ADP
admet-2043	123	8	vivo	vivo	ADJ
admet-2043	123	9	degradation	degradation	NOUN
admet-2043	123	10	,	,	PUNCT
admet-2043	123	11	v.	v.	ADP
admet-2043	123	12	the	the	DET
admet-2043	123	13	ability	ability	NOUN
admet-2043	123	14	to	to	PART
admet-2043	123	15	regulate	regulate	VERB
admet-2043	123	16	the	the	DET
admet-2043	123	17	release	release	NOUN
admet-2043	123	18	of	of	ADP
admet-2043	123	19	therapeutics	therapeutic	NOUN
admet-2043	123	20	over	over	ADP
admet-2043	123	21	extended	extended	ADJ
admet-2043	123	22	periods	period	NOUN
admet-2043	123	23	,	,	PUNCT
admet-2043	123	24	and	and	CCONJ
admet-2043	123	25	vi	vi	NOUN
admet-2043	123	26	.	.	PUNCT
admet-2043	124	1	the	the	DET
admet-2043	124	2	ability	ability	NOUN
admet-2043	124	3	to	to	PART
admet-2043	124	4	traverse	traverse	VERB
admet-2043	124	5	the	the	DET
admet-2043	124	6	bbb	bbb	PROPN
admet-2043	124	7	.	.	PUNCT
admet-2043	125	1	various	various	ADJ
admet-2043	125	2	nanomaterials	nanomaterial	NOUN
admet-2043	125	3	have	have	VERB
admet-2043	125	4	the	the	DET
admet-2043	125	5	capability	capability	NOUN
admet-2043	125	6	to	to	PART
admet-2043	125	7	encapsulate	encapsulate	VERB
admet-2043	125	8	,	,	PUNCT
admet-2043	125	9	absorb	absorb	VERB
admet-2043	125	10	,	,	PUNCT
admet-2043	125	11	attach	attach	VERB
admet-2043	125	12	,	,	PUNCT
admet-2043	125	13	or	or	CCONJ
admet-2043	125	14	trap	trap	NOUN
admet-2043	125	15	drug	drug	NOUN
admet-2043	125	16	moieties	moiety	NOUN
admet-2043	125	17	.	.	PUNCT
admet-2043	126	1	nanoparticles	nanoparticle	NOUN
admet-2043	126	2	or	or	CCONJ
admet-2043	126	3	nanomaterials	nanomaterial	NOUN
admet-2043	126	4	exhibit	exhibit	VERB
admet-2043	126	5	a	a	DET
admet-2043	126	6	noteworthy	noteworthy	ADJ
admet-2043	126	7	advantage	advantage	NOUN
admet-2043	126	8	in	in	SCONJ
admet-2043	126	9	that	that	SCONJ
admet-2043	126	10	they	they	PRON
admet-2043	126	11	can	can	AUX
admet-2043	126	12	be	be	AUX
admet-2043	126	13	employed	employ	VERB
admet-2043	126	14	for	for	ADP
admet-2043	126	15	intravenous	intravenous	ADJ
admet-2043	126	16	delivery	delivery	NOUN
admet-2043	126	17	in	in	ADP
admet-2043	126	18	preference	preference	NOUN
admet-2043	126	19	to	to	ADP
admet-2043	126	20	other	other	ADJ
admet-2043	126	21	microparticles	microparticle	NOUN
admet-2043	126	22	[	[	X
admet-2043	126	23	29	29	NUM
admet-2043	126	24	]	]	PUNCT
admet-2043	126	25	.	.	PUNCT
admet-2043	127	1	the	the	DET
admet-2043	127	2	diverse	diverse	ADJ
admet-2043	127	3	mechanisms	mechanism	NOUN
admet-2043	127	4	by	by	ADP
admet-2043	127	5	which	which	PRON
admet-2043	127	6	a	a	DET
admet-2043	127	7	pharmaceutical	pharmaceutical	ADJ
admet-2043	127	8	agent	agent	NOUN
admet-2043	127	9	can	can	AUX
admet-2043	127	10	be	be	AUX
admet-2043	127	11	administered	administer	VERB
admet-2043	127	12	to	to	ADP
admet-2043	127	13	the	the	DET
admet-2043	127	14	human	human	ADJ
admet-2043	127	15	blood	blood	NOUN
admet-2043	127	16	-	-	PUNCT
admet-2043	127	17	brain	brain	NOUN
admet-2043	127	18	barrier	barrier	NOUN
admet-2043	127	19	(	(	PUNCT
admet-2043	127	20	bbb	bbb	NOUN
admet-2043	127	21	)	)	PUNCT
admet-2043	127	22	comprise	comprise	VERB
admet-2043	127	23	the	the	DET
admet-2043	127	24	subsequent	subsequent	ADJ
admet-2043	127	25	approaches	approach	NOUN
admet-2043	127	26	admet	admet	PROPN
admet-2043	127	27	&	&	CCONJ
admet-2043	127	28	dmpk	dmpk	PROPN
admet-2043	127	29	12(1	12(1	PROPN
admet-2043	127	30	)	)	PUNCT
admet-2043	127	31	(	(	PUNCT
admet-2043	127	32	2024	2024	NUM
admet-2043	127	33	)	)	PUNCT
admet-2043	127	34	63	63	NUM
admet-2043	127	35	-	-	SYM
admet-2043	127	36	105	105	NUM
admet-2043	127	37	nanomaterials	nanomaterial	NOUN
admet-2043	127	38	as	as	ADP
admet-2043	127	39	drug	drug	NOUN
admet-2043	127	40	delivery	delivery	NOUN
admet-2043	127	41	agents	agent	NOUN
admet-2043	127	42	for	for	ADP
admet-2043	127	43	overcoming	overcome	VERB
admet-2043	127	44	bbb	bbb	PROPN
admet-2043	127	45	doi	doi	NOUN
admet-2043	127	46	:	:	PUNCT
admet-2043	127	47	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	127	48	69	69	NUM
admet-2043	127	49	mentioned	mention	VERB
admet-2043	127	50	in	in	ADP
admet-2043	127	51	figure	figure	NOUN
admet-2043	127	52	4	4	NUM
admet-2043	127	53	.	.	PUNCT
admet-2043	127	54	figure	figure	VERB
admet-2043	127	55	4	4	NUM
admet-2043	127	56	illustrates	illustrate	VERB
admet-2043	127	57	the	the	DET
admet-2043	127	58	diverse	diverse	ADJ
admet-2043	127	59	methodologies	methodology	NOUN
admet-2043	127	60	employed	employ	VERB
admet-2043	127	61	for	for	ADP
admet-2043	127	62	the	the	DET
admet-2043	127	63	transportation	transportation	NOUN
admet-2043	127	64	of	of	ADP
admet-2043	127	65	therapeutic	therapeutic	ADJ
admet-2043	127	66	agents	agent	NOUN
admet-2043	127	67	across	across	ADP
admet-2043	127	68	bbb	bbb	PROPN
admet-2043	127	69	.	.	PUNCT
admet-2043	128	1	figure	figure	NOUN
admet-2043	128	2	4	4	NUM
admet-2043	128	3	.	.	PUNCT
admet-2043	129	1	diverse	diverse	ADJ
admet-2043	129	2	methodologies	methodology	NOUN
admet-2043	129	3	employed	employ	VERB
admet-2043	129	4	for	for	ADP
admet-2043	129	5	the	the	DET
admet-2043	129	6	transportation	transportation	NOUN
admet-2043	129	7	of	of	ADP
admet-2043	129	8	therapeutic	therapeutic	ADJ
admet-2043	129	9	agents	agent	NOUN
admet-2043	129	10	.	.	PUNCT
admet-2043	130	1	the	the	DET
admet-2043	130	2	objective	objective	NOUN
admet-2043	130	3	is	be	AUX
admet-2043	130	4	to	to	PART
admet-2043	130	5	induce	induce	VERB
admet-2043	130	6	the	the	DET
admet-2043	130	7	opening	opening	NOUN
admet-2043	130	8	of	of	ADP
admet-2043	130	9	tjs	tjs	NOUN
admet-2043	130	10	or	or	CCONJ
admet-2043	130	11	elicit	elicit	ADJ
admet-2043	130	12	localized	localized	ADJ
admet-2043	130	13	toxic	toxic	ADJ
admet-2043	130	14	effects	effect	NOUN
admet-2043	130	15	,	,	PUNCT
admet-2043	130	16	which	which	PRON
admet-2043	130	17	may	may	AUX
admet-2043	130	18	lead	lead	VERB
admet-2043	130	19	to	to	ADP
admet-2043	130	20	an	an	DET
admet-2043	130	21	augmented	augment	VERB
admet-2043	130	22	permeability	permeability	NOUN
admet-2043	130	23	of	of	ADP
admet-2043	130	24	the	the	DET
admet-2043	130	25	bbb	bbb	PROPN
admet-2043	130	26	.	.	PUNCT
admet-2043	131	1	this	this	PRON
admet-2043	131	2	,	,	PUNCT
admet-2043	131	3	in	in	ADP
admet-2043	131	4	turn	turn	NOUN
admet-2043	131	5	,	,	PUNCT
admet-2043	131	6	would	would	AUX
admet-2043	131	7	make	make	VERB
admet-2043	131	8	it	it	PRON
admet-2043	131	9	possible	possible	ADJ
admet-2043	131	10	for	for	ADP
admet-2043	131	11	the	the	DET
admet-2043	131	12	infiltration	infiltration	NOUN
admet-2043	131	13	of	of	ADP
admet-2043	131	14	drugs	drug	NOUN
admet-2043	131	15	or	or	CCONJ
admet-2043	131	16	drugloaded	drugloade	VERB
admet-2043	131	17	nanomaterials	nanomaterial	NOUN
admet-2043	131	18	into	into	ADP
admet-2043	131	19	the	the	DET
admet-2043	131	20	cns	cns	NOUN
admet-2043	132	1	[	[	X
admet-2043	132	2	30	30	NUM
admet-2043	132	3	]	]	PUNCT
admet-2043	132	4	.	.	PUNCT
admet-2043	133	1	the	the	DET
admet-2043	133	2	transcytosis	transcytosis	NOUN
admet-2043	133	3	mechanism	mechanism	NOUN
admet-2043	133	4	enables	enable	VERB
admet-2043	133	5	passage	passage	NOUN
admet-2043	133	6	through	through	ADP
admet-2043	133	7	the	the	DET
admet-2043	133	8	ecs	ecs	PROPN
admet-2043	134	1	[	[	X
admet-2043	134	2	31	31	NUM
admet-2043	134	3	]	]	PUNCT
admet-2043	134	4	.	.	PUNCT
admet-2043	135	1	the	the	DET
admet-2043	135	2	ecs	ecs	PROPN
admet-2043	135	3	have	have	VERB
admet-2043	135	4	the	the	DET
admet-2043	135	5	ability	ability	NOUN
admet-2043	135	6	to	to	PART
admet-2043	135	7	internalize	internalize	VERB
admet-2043	135	8	the	the	DET
admet-2043	135	9	particles	particle	NOUN
admet-2043	135	10	through	through	ADP
admet-2043	135	11	the	the	DET
admet-2043	135	12	process	process	NOUN
admet-2043	135	13	of	of	ADP
admet-2043	135	14	endocytosis	endocytosis	NOUN
admet-2043	135	15	,	,	PUNCT
admet-2043	135	16	which	which	PRON
admet-2043	135	17	is	be	AUX
admet-2043	135	18	then	then	ADV
admet-2043	135	19	followed	follow	VERB
admet-2043	135	20	by	by	ADP
admet-2043	135	21	the	the	DET
admet-2043	135	22	release	release	NOUN
admet-2043	135	23	of	of	ADP
admet-2043	135	24	their	their	PRON
admet-2043	135	25	intracellular	intracellular	ADJ
admet-2043	135	26	cargo	cargo	NOUN
admet-2043	135	27	[	[	X
admet-2043	135	28	32	32	NUM
admet-2043	135	29	]	]	PUNCT
admet-2043	135	30	.	.	PUNCT
admet-2043	136	1	table	table	NOUN
admet-2043	136	2	1	1	NUM
admet-2043	136	3	depicts	depict	VERB
admet-2043	136	4	techniques	technique	NOUN
admet-2043	136	5	involving	involve	VERB
admet-2043	136	6	invasive	invasive	ADJ
admet-2043	136	7	and	and	CCONJ
admet-2043	136	8	non	non	ADJ
admet-2043	136	9	-	-	ADJ
admet-2043	136	10	invasive	invasive	ADJ
admet-2043	136	11	routes	route	NOUN
admet-2043	136	12	to	to	PART
admet-2043	136	13	deliver	deliver	VERB
admet-2043	136	14	therapeutics	therapeutic	NOUN
admet-2043	136	15	to	to	ADP
admet-2043	136	16	the	the	DET
admet-2043	136	17	human	human	ADJ
admet-2043	136	18	brain	brain	NOUN
admet-2043	136	19	.	.	PUNCT
admet-2043	137	1	table	table	NOUN
admet-2043	137	2	1	1	NUM
admet-2043	137	3	.	.	X
admet-2043	137	4	list	list	NOUN
admet-2043	137	5	of	of	ADP
admet-2043	137	6	invasive	invasive	ADJ
admet-2043	137	7	and	and	CCONJ
admet-2043	137	8	non	non	ADJ
admet-2043	137	9	-	-	ADJ
admet-2043	137	10	invasive	invasive	ADJ
admet-2043	137	11	techniques	technique	NOUN
admet-2043	137	12	for	for	ADP
admet-2043	137	13	drug	drug	NOUN
admet-2043	137	14	delivery	delivery	NOUN
admet-2043	137	15	to	to	ADP
admet-2043	137	16	the	the	DET
admet-2043	137	17	human	human	ADJ
admet-2043	137	18	brain	brain	NOUN
admet-2043	137	19	techniques	technique	NOUN
admet-2043	137	20	methods	method	NOUN
admet-2043	137	21	/	/	SYM
admet-2043	137	22	mode	mode	NOUN
admet-2043	137	23	strategy	strategy	NOUN
admet-2043	137	24	invasive	invasive	ADJ
admet-2043	137	25	bbb	bbb	PROPN
admet-2043	137	26	disruption	disruption	NOUN
admet-2043	137	27	techniques	technique	NOUN
admet-2043	137	28	osmotic	osmotic	ADJ
admet-2043	137	29	bbb	bbb	PROPN
admet-2043	137	30	disruption	disruption	NOUN
admet-2043	137	31	strategy	strategy	NOUN
admet-2043	137	32	,	,	PUNCT
admet-2043	137	33	biochemical	biochemical	ADJ
admet-2043	137	34	bbb	bbb	NOUN
admet-2043	137	35	disruption	disruption	NOUN
admet-2043	137	36	strategy	strategy	NOUN
admet-2043	137	37	,	,	PUNCT
admet-2043	137	38	ultrasound	ultrasound	NOUN
admet-2043	137	39	mediated	mediate	VERB
admet-2043	137	40	bbb	bbb	NOUN
admet-2043	137	41	disruption	disruption	NOUN
admet-2043	137	42	strategy	strategy	NOUN
admet-2043	138	1	[	[	X
admet-2043	138	2	33	33	NUM
admet-2043	138	3	]	]	PUNCT
admet-2043	138	4	other	other	ADJ
admet-2043	138	5	routes	route	NOUN
admet-2043	138	6	for	for	ADP
admet-2043	138	7	cns	cns	NOUN
admet-2043	138	8	drug	drug	NOUN
admet-2043	138	9	delivery	delivery	NOUN
admet-2043	138	10	other	other	ADJ
admet-2043	138	11	routes	route	NOUN
admet-2043	138	12	olfactory	olfactory	ADJ
admet-2043	138	13	pathway	pathway	NOUN
admet-2043	138	14	,	,	PUNCT
admet-2043	138	15	trigeminal	trigeminal	ADJ
admet-2043	138	16	pathway	pathway	NOUN
admet-2043	138	17	,	,	PUNCT
admet-2043	138	18	intranasal	intranasal	ADJ
admet-2043	138	19	delivery	delivery	NOUN
admet-2043	138	20	,	,	PUNCT
admet-2043	138	21	iontophoretic	iontophoretic	ADJ
admet-2043	138	22	delivery	delivery	NOUN
admet-2043	138	23	non	non	ADJ
admet-2043	138	24	-	-	ADJ
admet-2043	138	25	invasive	invasive	ADJ
admet-2043	138	26	chemical	chemical	ADJ
admet-2043	138	27	lipophilic	lipophilic	ADJ
admet-2043	138	28	analogs	analog	NOUN
admet-2043	138	29	,	,	PUNCT
admet-2043	138	30	prodrugs	prodrug	NOUN
admet-2043	138	31	,	,	PUNCT
admet-2043	138	32	chemical	chemical	NOUN
admet-2043	138	33	drug	drug	NOUN
admet-2043	138	34	delivery	delivery	NOUN
admet-2043	138	35	system	system	NOUN
admet-2043	138	36	,	,	PUNCT
admet-2043	138	37	molecular	molecular	ADJ
admet-2043	138	38	packaging	packaging	NOUN
admet-2043	138	39	,	,	PUNCT
admet-2043	138	40	receptor	receptor	NOUN
admet-2043	138	41	/	/	SYM
admet-2043	138	42	vector	vector	NOUN
admet-2043	138	43	mediated	mediate	VERB
admet-2043	138	44	delivery	delivery	NOUN
admet-2043	138	45	of	of	ADP
admet-2043	138	46	chimeric	chimeric	ADJ
admet-2043	138	47	peptides	peptide	NOUN
admet-2043	138	48	non	non	ADJ
admet-2043	138	49	-	-	ADJ
admet-2043	138	50	invasive	invasive	ADJ
admet-2043	138	51	biological	biological	ADJ
admet-2043	138	52	viral	viral	ADJ
admet-2043	138	53	vectors	vector	NOUN
admet-2043	138	54	,	,	PUNCT
admet-2043	138	55	cell	cell	NOUN
admet-2043	138	56	penetrating	penetrate	VERB
admet-2043	138	57	peptide	peptide	NOUN
admet-2043	138	58	-	-	PUNCT
admet-2043	138	59	mediated	mediate	VERB
admet-2043	138	60	drug	drug	NOUN
admet-2043	138	61	delivery	delivery	NOUN
admet-2043	138	62	,	,	PUNCT
admet-2043	138	63	nanospheres	nanosphere	NOUN
admet-2043	138	64	,	,	PUNCT
admet-2043	138	65	nano	nano	NOUN
admet-2043	138	66	capsules	capsule	NOUN
admet-2043	138	67	non	non	ADJ
admet-2043	138	68	-	-	ADJ
admet-2043	138	69	invasive	invasive	ADJ
admet-2043	138	70	colloidal	colloidal	NOUN
admet-2043	138	71	drug	drug	NOUN
admet-2043	138	72	carriers	carrier	NOUN
admet-2043	138	73	solid	solid	ADJ
admet-2043	138	74	lipid	lipid	ADJ
admet-2043	138	75	nanoparticles	nanoparticle	NOUN
admet-2043	138	76	(	(	PUNCT
admet-2043	138	77	slns	slns	NOUN
admet-2043	138	78	)	)	PUNCT
admet-2043	138	79	,	,	PUNCT
admet-2043	138	80	dendrimers	dendrimer	NOUN
admet-2043	138	81	,	,	PUNCT
admet-2043	138	82	single	single	ADJ
admet-2043	138	83	and	and	CCONJ
admet-2043	138	84	multiwalled	multiwalle	VERB
admet-2043	138	85	carbon	carbon	NOUN
admet-2043	138	86	nanotubes	nanotube	NOUN
admet-2043	138	87	[	[	PUNCT
admet-2043	138	88	34	34	NUM
admet-2043	138	89	]	]	X
admet-2043	138	90	non	non	ADJ
admet-2043	138	91	-	-	ADJ
admet-2043	138	92	invasive	invasive	ADJ
admet-2043	138	93	pharmacological	pharmacological	ADJ
admet-2043	138	94	intraventricular	intraventricular	ADJ
admet-2043	138	95	/	/	SYM
admet-2043	138	96	intrathecal	intrathecal	ADJ
admet-2043	138	97	/	/	SYM
admet-2043	138	98	interstitial	interstitial	ADJ
admet-2043	138	99	delivery	delivery	NOUN
admet-2043	138	100	,	,	PUNCT
admet-2043	138	101	biological	biological	ADJ
admet-2043	138	102	tissue	tissue	NOUN
admet-2043	138	103	delivery	delivery	NOUN
admet-2043	138	104	,	,	PUNCT
admet-2043	138	105	convection	convection	NOUN
admet-2043	138	106	-	-	PUNCT
admet-2043	138	107	enhanced	enhance	VERB
admet-2043	138	108	delivery	delivery	NOUN
admet-2043	138	109	[	[	X
admet-2043	138	110	35	35	NUM
admet-2043	138	111	]	]	SYM
admet-2043	138	112	ideal	ideal	ADJ
admet-2043	138	113	properties	property	NOUN
admet-2043	138	114	of	of	ADP
admet-2043	138	115	nanomaterials	nanomaterial	NOUN
admet-2043	138	116	figure	figure	NOUN
admet-2043	138	117	5	5	NUM
admet-2043	138	118	outlines	outline	VERB
admet-2043	138	119	the	the	DET
admet-2043	138	120	optimal	optimal	ADJ
admet-2043	138	121	prerequisites	prerequisite	NOUN
admet-2043	138	122	for	for	SCONJ
admet-2043	138	123	a	a	DET
admet-2043	138	124	nanomaterial	nanomaterial	NOUN
admet-2043	138	125	to	to	PART
admet-2043	138	126	be	be	AUX
admet-2043	138	127	considered	consider	VERB
admet-2043	138	128	suitable	suitable	ADJ
admet-2043	138	129	for	for	ADP
admet-2043	138	130	the	the	DET
admet-2043	138	131	delivery	delivery	NOUN
admet-2043	138	132	of	of	ADP
admet-2043	138	133	drugs	drug	NOUN
admet-2043	138	134	to	to	ADP
admet-2043	138	135	the	the	DET
admet-2043	138	136	human	human	ADJ
admet-2043	138	137	brain	brain	NOUN
admet-2043	138	138	.	.	PUNCT
admet-2043	139	1	figure	figure	NOUN
admet-2043	139	2	5	5	NUM
admet-2043	139	3	mentions	mention	VERB
admet-2043	139	4	the	the	DET
admet-2043	139	5	ideal	ideal	ADJ
admet-2043	139	6	prerequisites	prerequisite	NOUN
admet-2043	139	7	for	for	SCONJ
admet-2043	139	8	nanomaterials	nanomaterial	NOUN
admet-2043	139	9	to	to	PART
admet-2043	139	10	be	be	AUX
admet-2043	139	11	used	use	VERB
admet-2043	139	12	in	in	ADP
admet-2043	139	13	therapeutics	therapeutic	NOUN
admet-2043	139	14	.	.	PUNCT
admet-2043	140	1	nanomaterials	nanomaterial	NOUN
admet-2043	140	2	explored	explore	VERB
admet-2043	140	3	for	for	ADP
admet-2043	140	4	drug	drug	NOUN
admet-2043	140	5	delivery	delivery	NOUN
admet-2043	140	6	to	to	ADP
admet-2043	140	7	the	the	DET
admet-2043	140	8	brain	brain	NOUN
admet-2043	140	9	in	in	ADP
admet-2043	140	10	1961	1961	NUM
admet-2043	140	11	,	,	PUNCT
admet-2043	140	12	muller	muller	NOUN
admet-2043	140	13	and	and	CCONJ
admet-2043	140	14	gasco	gasco	NOUN
admet-2043	140	15	rendered	render	VERB
admet-2043	140	16	the	the	DET
admet-2043	140	17	discovery	discovery	NOUN
admet-2043	140	18	of	of	ADP
admet-2043	140	19	lipidic	lipidic	ADJ
admet-2043	140	20	nanoparticles	nanoparticle	NOUN
admet-2043	140	21	.	.	PUNCT
admet-2043	141	1	lipidic	lipidic	ADJ
admet-2043	141	2	nanoparticles	nanoparticle	NOUN
admet-2043	141	3	(	(	PUNCT
admet-2043	141	4	lns	lns	PROPN
admet-2043	141	5	)	)	PUNCT
admet-2043	141	6	are	be	AUX
admet-2043	141	7	a	a	DET
admet-2043	141	8	class	class	NOUN
admet-2043	141	9	of	of	ADP
admet-2043	141	10	nanotechnology	nanotechnology	NOUN
admet-2043	141	11	drug	drug	NOUN
admet-2043	141	12	delivery	delivery	NOUN
admet-2043	141	13	systems	system	NOUN
admet-2043	141	14	that	that	PRON
admet-2043	141	15	encompass	encompass	VERB
admet-2043	141	16	solid	solid	ADJ
admet-2043	141	17	lipid	lipid	NOUN
admet-2043	141	18	nanoparticles	nanoparticle	NOUN
admet-2043	141	19	(	(	PUNCT
admet-2043	141	20	slns	slns	NOUN
admet-2043	141	21	)	)	PUNCT
admet-2043	142	1	[	[	X
admet-2043	142	2	36	36	NUM
admet-2043	142	3	]	]	PUNCT
admet-2043	142	4	,	,	PUNCT
admet-2043	142	5	nanostructured	nanostructure	VERB
admet-2043	142	6	lipid	lipid	NOUN
admet-2043	142	7	carriers	carrier	NOUN
admet-2043	142	8	(	(	PUNCT
admet-2043	142	9	nlcs	nlcs	PROPN
admet-2043	142	10	)	)	PUNCT
admet-2043	142	11	,	,	PUNCT
admet-2043	142	12	and	and	CCONJ
admet-2043	142	13	liposomes	liposome	VERB
admet-2043	142	14	[	[	X
admet-2043	142	15	37	37	NUM
admet-2043	142	16	]	]	PUNCT
admet-2043	142	17	.	.	PUNCT
admet-2043	143	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	143	2	m.	m.	NOUN
admet-2043	143	3	kulkarni	kulkarni	PROPN
admet-2043	143	4	et	et	PROPN
admet-2043	143	5	al	al	PROPN
admet-2043	143	6	.	.	PROPN
admet-2043	143	7	admet	admet	PROPN
admet-2043	143	8	&	&	CCONJ
admet-2043	143	9	dmpk	dmpk	PROPN
admet-2043	143	10	12(1	12(1	PROPN
admet-2043	143	11	)	)	PUNCT
admet-2043	143	12	(	(	PUNCT
admet-2043	143	13	2024	2024	NUM
admet-2043	143	14	)	)	PUNCT
admet-2043	143	15	63	63	NUM
admet-2043	143	16	-	-	SYM
admet-2043	143	17	105	105	NUM
admet-2043	143	18	70	70	NUM
admet-2043	143	19	figure	figure	NOUN
admet-2043	143	20	5	5	NUM
admet-2043	143	21	.	.	PUNCT
admet-2043	143	22	ideal	ideal	ADJ
admet-2043	143	23	properties	property	NOUN
admet-2043	143	24	of	of	ADP
admet-2043	143	25	nanomaterials	nanomaterial	NOUN
admet-2043	143	26	to	to	PART
admet-2043	143	27	deliver	deliver	VERB
admet-2043	143	28	drugs	drug	NOUN
admet-2043	143	29	across	across	ADP
admet-2043	143	30	bbb	bbb	PROPN
admet-2043	143	31	lns	lns	PROPN
admet-2043	143	32	exhibit	exhibit	VERB
admet-2043	143	33	a	a	DET
admet-2043	143	34	number	number	NOUN
admet-2043	143	35	of	of	ADP
admet-2043	143	36	benefits	benefit	NOUN
admet-2043	143	37	over	over	ADP
admet-2043	143	38	colloidal	colloidal	NOUN
admet-2043	143	39	nanoparticles	nanoparticle	NOUN
admet-2043	143	40	,	,	PUNCT
admet-2043	143	41	including	include	VERB
admet-2043	143	42	improved	improve	VERB
admet-2043	143	43	drug	drug	NOUN
admet-2043	143	44	entrapment	entrapment	NOUN
admet-2043	143	45	,	,	PUNCT
admet-2043	143	46	extended	extend	VERB
admet-2043	143	47	drug	drug	NOUN
admet-2043	143	48	release	release	NOUN
admet-2043	143	49	,	,	PUNCT
admet-2043	143	50	amplified	amplify	VERB
admet-2043	143	51	physical	physical	ADJ
admet-2043	143	52	and	and	CCONJ
admet-2043	143	53	chemical	chemical	NOUN
admet-2043	143	54	stability	stability	NOUN
admet-2043	143	55	,	,	PUNCT
admet-2043	143	56	and	and	CCONJ
admet-2043	143	57	superior	superior	ADJ
admet-2043	143	58	incorporation	incorporation	NOUN
admet-2043	143	59	or	or	CCONJ
admet-2043	143	60	encapsulation	encapsulation	NOUN
admet-2043	143	61	of	of	ADP
admet-2043	143	62	lipophilic	lipophilic	ADJ
admet-2043	143	63	drugs	drug	NOUN
admet-2043	143	64	within	within	ADP
admet-2043	143	65	the	the	DET
admet-2043	143	66	core	core	NOUN
admet-2043	143	67	of	of	ADP
admet-2043	143	68	slns	slns	NOUN
admet-2043	144	1	[	[	X
admet-2043	144	2	38	38	NUM
admet-2043	144	3	]	]	PUNCT
admet-2043	144	4	and	and	CCONJ
admet-2043	144	5	nlcs	nlcs	PROPN
admet-2043	144	6	[	[	X
admet-2043	144	7	39	39	NUM
admet-2043	144	8	]	]	PUNCT
admet-2043	144	9	.	.	PUNCT
admet-2043	145	1	figure	figure	NOUN
admet-2043	145	2	6	6	NUM
admet-2043	145	3	represents	represent	VERB
admet-2043	145	4	various	various	ADJ
admet-2043	145	5	types	type	NOUN
admet-2043	145	6	of	of	ADP
admet-2043	145	7	lipidic	lipidic	ADJ
admet-2043	145	8	nanoparticles	nanoparticle	NOUN
admet-2043	145	9	.	.	PUNCT
admet-2043	146	1	it	it	PRON
admet-2043	146	2	generally	generally	ADV
admet-2043	146	3	encompasses	encompass	VERB
admet-2043	146	4	slns	slns	NOUN
admet-2043	146	5	,	,	PUNCT
admet-2043	146	6	nlcs	nlcs	PROPN
admet-2043	146	7	,	,	PUNCT
admet-2043	146	8	liposomes	liposome	NOUN
admet-2043	146	9	,	,	PUNCT
admet-2043	146	10	transferosomes	transferosome	NOUN
admet-2043	146	11	and	and	CCONJ
admet-2043	146	12	niosomes	niosome	NOUN
admet-2043	146	13	.	.	PUNCT
admet-2043	147	1	these	these	DET
admet-2043	147	2	nanoparticles	nanoparticle	NOUN
admet-2043	147	3	offer	offer	VERB
admet-2043	147	4	a	a	DET
admet-2043	147	5	range	range	NOUN
admet-2043	147	6	of	of	ADP
admet-2043	147	7	advantages	advantage	NOUN
admet-2043	147	8	over	over	ADP
admet-2043	147	9	colloidal	colloidal	NOUN
admet-2043	147	10	nanoparticles	nanoparticle	NOUN
admet-2043	147	11	.	.	PUNCT
admet-2043	148	1	firstly	firstly	ADV
admet-2043	148	2	,	,	PUNCT
admet-2043	148	3	they	they	PRON
admet-2043	148	4	demonstrate	demonstrate	VERB
admet-2043	148	5	improved	improved	ADJ
admet-2043	148	6	drug	drug	NOUN
admet-2043	148	7	entrapment	entrapment	NOUN
admet-2043	148	8	,	,	PUNCT
admet-2043	148	9	ensuring	ensure	VERB
admet-2043	148	10	a	a	DET
admet-2043	148	11	higher	high	ADJ
admet-2043	148	12	drug	drug	NOUN
admet-2043	148	13	payload	payload	NOUN
admet-2043	148	14	can	can	AUX
admet-2043	148	15	be	be	AUX
admet-2043	148	16	incorporated	incorporate	VERB
admet-2043	148	17	.	.	PUNCT
admet-2043	149	1	secondly	secondly	ADV
admet-2043	149	2	,	,	PUNCT
admet-2043	149	3	lipid	lipid	NOUN
admet-2043	149	4	nanoparticles	nanoparticle	NOUN
admet-2043	149	5	enable	enable	VERB
admet-2043	149	6	extended	extended	ADJ
admet-2043	149	7	drug	drug	NOUN
admet-2043	149	8	release	release	NOUN
admet-2043	149	9	,	,	PUNCT
admet-2043	149	10	ensuring	ensure	VERB
admet-2043	149	11	a	a	DET
admet-2043	149	12	more	more	ADV
admet-2043	149	13	sustained	sustained	ADJ
admet-2043	149	14	and	and	CCONJ
admet-2043	149	15	controlled	control	VERB
admet-2043	149	16	drug	drug	NOUN
admet-2043	149	17	release	release	NOUN
admet-2043	149	18	,	,	PUNCT
admet-2043	149	19	which	which	PRON
admet-2043	149	20	is	be	AUX
admet-2043	149	21	crucial	crucial	ADJ
admet-2043	149	22	for	for	ADP
admet-2043	149	23	effective	effective	ADJ
admet-2043	149	24	therapeutic	therapeutic	ADJ
admet-2043	149	25	outcomes	outcome	NOUN
admet-2043	149	26	.	.	PUNCT
admet-2043	150	1	additionally	additionally	ADV
admet-2043	150	2	,	,	PUNCT
admet-2043	150	3	they	they	PRON
admet-2043	150	4	provide	provide	VERB
admet-2043	150	5	enhanced	enhance	VERB
admet-2043	150	6	physical	physical	ADJ
admet-2043	150	7	and	and	CCONJ
admet-2043	150	8	chemical	chemical	NOUN
admet-2043	150	9	stability	stability	NOUN
admet-2043	150	10	,	,	PUNCT
admet-2043	150	11	making	make	VERB
admet-2043	150	12	them	they	PRON
admet-2043	150	13	a	a	DET
admet-2043	150	14	reliable	reliable	ADJ
admet-2043	150	15	choice	choice	NOUN
admet-2043	150	16	for	for	ADP
admet-2043	150	17	drug	drug	NOUN
admet-2043	150	18	delivery	delivery	NOUN
admet-2043	150	19	systems	system	NOUN
admet-2043	150	20	.	.	PUNCT
admet-2043	151	1	notably	notably	ADV
admet-2043	151	2	,	,	PUNCT
admet-2043	151	3	lipid	lipid	ADJ
admet-2043	151	4	nanoparticles	nanoparticle	NOUN
admet-2043	151	5	excel	excel	VERB
admet-2043	151	6	in	in	ADP
admet-2043	151	7	incorporating	incorporate	VERB
admet-2043	151	8	or	or	CCONJ
admet-2043	151	9	encapsulating	encapsulate	VERB
admet-2043	151	10	lipophilic	lipophilic	ADJ
admet-2043	151	11	drugs	drug	NOUN
admet-2043	151	12	within	within	ADP
admet-2043	151	13	the	the	DET
admet-2043	151	14	core	core	NOUN
admet-2043	151	15	,	,	PUNCT
admet-2043	151	16	making	make	VERB
admet-2043	151	17	them	they	PRON
admet-2043	151	18	efficient	efficient	ADJ
admet-2043	151	19	carriers	carrier	NOUN
admet-2043	151	20	for	for	ADP
admet-2043	151	21	these	these	DET
admet-2043	151	22	types	type	NOUN
admet-2043	151	23	of	of	ADP
admet-2043	151	24	drugs	drug	NOUN
admet-2043	151	25	.	.	PUNCT
admet-2043	152	1	slns	slns	NOUN
admet-2043	152	2	and	and	CCONJ
admet-2043	152	3	nlcs	nlcs	PROPN
admet-2043	152	4	are	be	AUX
admet-2043	152	5	specifically	specifically	ADV
admet-2043	152	6	highlighted	highlight	VERB
admet-2043	152	7	within	within	ADP
admet-2043	152	8	this	this	DET
admet-2043	152	9	category	category	NOUN
admet-2043	152	10	of	of	ADP
admet-2043	152	11	nanoparticles	nanoparticle	NOUN
admet-2043	152	12	.	.	PUNCT
admet-2043	153	1	these	these	DET
admet-2043	153	2	subtypes	subtype	NOUN
admet-2043	153	3	offer	offer	VERB
admet-2043	153	4	versatile	versatile	ADJ
admet-2043	153	5	drug	drug	NOUN
admet-2043	153	6	delivery	delivery	NOUN
admet-2043	153	7	options	option	NOUN
admet-2043	153	8	due	due	ADP
admet-2043	153	9	to	to	ADP
admet-2043	153	10	their	their	PRON
admet-2043	153	11	solid	solid	ADJ
admet-2043	153	12	lipid	lipid	NOUN
admet-2043	153	13	matrix	matrix	NOUN
admet-2043	153	14	that	that	PRON
admet-2043	153	15	can	can	AUX
admet-2043	153	16	effectively	effectively	ADV
admet-2043	153	17	entrap	entrap	VERB
admet-2043	153	18	drugs	drug	NOUN
admet-2043	153	19	.	.	PUNCT
admet-2043	154	1	liposomes	liposome	NOUN
admet-2043	154	2	,	,	PUNCT
admet-2043	154	3	transferosomes	transferosome	NOUN
admet-2043	154	4	,	,	PUNCT
admet-2043	154	5	and	and	CCONJ
admet-2043	154	6	niosomes	niosome	NOUN
admet-2043	154	7	are	be	AUX
admet-2043	154	8	also	also	ADV
admet-2043	154	9	part	part	NOUN
admet-2043	154	10	of	of	ADP
admet-2043	154	11	this	this	DET
admet-2043	154	12	category	category	NOUN
admet-2043	154	13	and	and	CCONJ
admet-2043	154	14	contribute	contribute	VERB
admet-2043	154	15	to	to	ADP
admet-2043	154	16	the	the	DET
admet-2043	154	17	diverse	diverse	ADJ
admet-2043	154	18	array	array	NOUN
admet-2043	154	19	of	of	ADP
admet-2043	154	20	lipidic	lipidic	ADJ
admet-2043	154	21	nanoparticles	nanoparticle	NOUN
admet-2043	154	22	available	available	ADJ
admet-2043	154	23	for	for	ADP
admet-2043	154	24	drug	drug	NOUN
admet-2043	154	25	delivery	delivery	NOUN
admet-2043	154	26	.	.	PUNCT
admet-2043	155	1	figure	figure	NOUN
admet-2043	155	2	6	6	NUM
admet-2043	155	3	.	.	PUNCT
admet-2043	156	1	several	several	ADJ
admet-2043	156	2	types	type	NOUN
admet-2043	156	3	of	of	ADP
admet-2043	156	4	lipidic	lipidic	ADJ
admet-2043	156	5	nanoparticles	nanoparticle	NOUN
admet-2043	156	6	the	the	DET
admet-2043	156	7	main	main	ADJ
admet-2043	156	8	lipid	lipid	NOUN
admet-2043	156	9	-	-	PUNCT
admet-2043	156	10	based	base	VERB
admet-2043	156	11	carriers	carrier	NOUN
admet-2043	156	12	include	include	VERB
admet-2043	156	13	:	:	PUNCT
admet-2043	156	14	a	a	X
admet-2043	156	15	)	)	PUNCT
admet-2043	156	16	niosomes	niosome	NOUN
admet-2043	156	17	:	:	PUNCT
admet-2043	156	18	niosomes	niosome	NOUN
admet-2043	156	19	are	be	AUX
admet-2043	156	20	lamellar	lamellar	ADJ
admet-2043	156	21	,	,	PUNCT
admet-2043	156	22	self	self	NOUN
admet-2043	156	23	-	-	PUNCT
admet-2043	156	24	assembled	assemble	VERB
admet-2043	156	25	structures	structure	NOUN
admet-2043	156	26	comprising	comprise	VERB
admet-2043	156	27	non	non	ADJ
admet-2043	156	28	-	-	ADJ
admet-2043	156	29	ionic	ionic	ADJ
admet-2043	156	30	surfactants	surfactant	NOUN
admet-2043	156	31	and	and	CCONJ
admet-2043	156	32	cholesterol	cholesterol	NOUN
admet-2043	157	1	[	[	X
admet-2043	157	2	40	40	NUM
admet-2043	157	3	]	]	PUNCT
admet-2043	157	4	.	.	PUNCT
admet-2043	158	1	b	b	X
admet-2043	158	2	)	)	PUNCT
admet-2043	158	3	transferosomes	transferosome	NOUN
admet-2043	158	4	:	:	PUNCT
admet-2043	158	5	they	they	PRON
admet-2043	158	6	are	be	AUX
admet-2043	158	7	identical	identical	ADJ
admet-2043	158	8	to	to	ADP
admet-2043	158	9	niosomes	niosome	NOUN
admet-2043	158	10	and	and	CCONJ
admet-2043	158	11	liposomes	liposome	NOUN
admet-2043	158	12	and	and	CCONJ
admet-2043	158	13	they	they	PRON
admet-2043	158	14	also	also	ADV
admet-2043	158	15	have	have	VERB
admet-2043	158	16	a	a	DET
admet-2043	158	17	lipid	lipid	ADJ
admet-2043	158	18	bilayer	bilayer	NOUN
admet-2043	158	19	developed	develop	VERB
admet-2043	158	20	by	by	ADP
admet-2043	158	21	a	a	DET
admet-2043	158	22	lipid	lipid	NOUN
admet-2043	158	23	matrix	matrix	NOUN
admet-2043	158	24	that	that	PRON
admet-2043	158	25	is	be	AUX
admet-2043	158	26	stabilized	stabilize	VERB
admet-2043	158	27	by	by	ADP
admet-2043	158	28	the	the	DET
admet-2043	158	29	usage	usage	NOUN
admet-2043	158	30	of	of	ADP
admet-2043	158	31	several	several	ADJ
admet-2043	158	32	surfactants	surfactant	NOUN
admet-2043	158	33	.	.	PUNCT
admet-2043	159	1	c	c	X
admet-2043	159	2	)	)	PUNCT
admet-2043	159	3	liposomes	liposome	NOUN
admet-2043	159	4	:	:	PUNCT
admet-2043	159	5	the	the	DET
admet-2043	159	6	liposomes	liposome	NOUN
admet-2043	159	7	are	be	AUX
admet-2043	159	8	bilayer	bilayer	NOUN
admet-2043	159	9	vesicles	vesicle	NOUN
admet-2043	159	10	consisting	consist	VERB
admet-2043	159	11	of	of	ADP
admet-2043	159	12	phospholipids	phospholipid	NOUN
admet-2043	160	1	[	[	X
admet-2043	160	2	41,42	41,42	NOUN
admet-2043	160	3	]	]	PUNCT
admet-2043	160	4	.	.	PUNCT
admet-2043	161	1	admet	admet	PROPN
admet-2043	161	2	&	&	CCONJ
admet-2043	161	3	dmpk	dmpk	PROPN
admet-2043	161	4	12(1	12(1	PROPN
admet-2043	161	5	)	)	PUNCT
admet-2043	161	6	(	(	PUNCT
admet-2043	161	7	2024	2024	NUM
admet-2043	161	8	)	)	PUNCT
admet-2043	161	9	63	63	NUM
admet-2043	161	10	-	-	SYM
admet-2043	161	11	105	105	NUM
admet-2043	161	12	nanomaterials	nanomaterial	NOUN
admet-2043	161	13	as	as	ADP
admet-2043	161	14	drug	drug	NOUN
admet-2043	161	15	delivery	delivery	NOUN
admet-2043	161	16	agents	agent	NOUN
admet-2043	161	17	for	for	ADP
admet-2043	161	18	overcoming	overcome	VERB
admet-2043	161	19	bbb	bbb	PROPN
admet-2043	161	20	doi	doi	NOUN
admet-2043	161	21	:	:	PUNCT
admet-2043	161	22	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	161	23	71	71	NUM
admet-2043	161	24	d	d	NOUN
admet-2043	161	25	)	)	PUNCT
admet-2043	161	26	solid	solid	ADJ
admet-2043	161	27	lipid	lipid	NOUN
admet-2043	161	28	nanoparticles	nanoparticle	NOUN
admet-2043	161	29	(	(	PUNCT
admet-2043	161	30	slns	slns	NOUN
admet-2043	161	31	):	):	PUNCT
admet-2043	161	32	the	the	DET
admet-2043	161	33	slns	slns	NOUN
admet-2043	161	34	contain	contain	VERB
admet-2043	161	35	a	a	DET
admet-2043	161	36	core	core	NOUN
admet-2043	161	37	of	of	ADP
admet-2043	161	38	solid	solid	ADJ
admet-2043	161	39	lipid	lipid	NOUN
admet-2043	161	40	that	that	PRON
admet-2043	161	41	helps	help	VERB
admet-2043	161	42	to	to	PART
admet-2043	161	43	encapsulate	encapsulate	VERB
admet-2043	161	44	the	the	DET
admet-2043	161	45	drug	drug	NOUN
admet-2043	161	46	[	[	X
admet-2043	161	47	43	43	NUM
admet-2043	161	48	]	]	PUNCT
admet-2043	161	49	.	.	PUNCT
admet-2043	162	1	e	e	X
admet-2043	162	2	)	)	PUNCT
admet-2043	162	3	nanostructured	nanostructure	VERB
admet-2043	162	4	lipid	lipid	NOUN
admet-2043	162	5	carriers	carrier	NOUN
admet-2043	162	6	(	(	PUNCT
admet-2043	162	7	nlcs	nlcs	PROPN
admet-2043	162	8	):	):	PUNCT
admet-2043	162	9	the	the	DET
admet-2043	162	10	nlcs	nlcs	NOUN
admet-2043	162	11	have	have	VERB
admet-2043	162	12	a	a	DET
admet-2043	162	13	core	core	NOUN
admet-2043	162	14	of	of	ADP
admet-2043	162	15	liquid	liquid	ADJ
admet-2043	162	16	lipid	lipid	NOUN
admet-2043	162	17	interior	interior	NOUN
admet-2043	162	18	to	to	ADP
admet-2043	162	19	the	the	DET
admet-2043	162	20	solid	solid	ADJ
admet-2043	162	21	lipid	lipid	NOUN
admet-2043	162	22	phase	phase	NOUN
admet-2043	162	23	[	[	X
admet-2043	162	24	44	44	NUM
admet-2043	162	25	]	]	PUNCT
admet-2043	162	26	.	.	PUNCT
admet-2043	163	1	strategies	strategy	NOUN
admet-2043	163	2	to	to	PART
admet-2043	163	3	modify	modify	VERB
admet-2043	163	4	drug	drug	NOUN
admet-2043	163	5	release	release	NOUN
admet-2043	163	6	through	through	ADP
admet-2043	163	7	bbb	bbb	PROPN
admet-2043	163	8	penetration	penetration	NOUN
admet-2043	163	9	physiological	physiological	ADJ
admet-2043	163	10	transport	transport	NOUN
admet-2043	163	11	mechanism	mechanism	NOUN
admet-2043	163	12	receptor	receptor	NOUN
admet-2043	163	13	-	-	PUNCT
admet-2043	163	14	mediated	mediate	VERB
admet-2043	163	15	transportation	transportation	NOUN
admet-2043	163	16	(	(	PUNCT
admet-2043	163	17	rmt	rmt	NOUN
admet-2043	163	18	)	)	PUNCT
admet-2043	163	19	receptor	receptor	NOUN
admet-2043	163	20	-	-	PUNCT
admet-2043	163	21	mediated	mediate	VERB
admet-2043	163	22	transcytosis	transcytosis	NOUN
admet-2043	163	23	encompasses	encompass	VERB
admet-2043	163	24	the	the	DET
admet-2043	163	25	intricate	intricate	ADJ
admet-2043	163	26	process	process	NOUN
admet-2043	163	27	by	by	ADP
admet-2043	163	28	which	which	DET
admet-2043	163	29	nanoparticles	nanoparticle	NOUN
admet-2043	163	30	effectively	effectively	ADV
admet-2043	163	31	interact	interact	VERB
admet-2043	163	32	with	with	ADP
admet-2043	163	33	specific	specific	ADJ
admet-2043	163	34	receptors	receptor	NOUN
admet-2043	163	35	situated	situate	VERB
admet-2043	163	36	on	on	ADP
admet-2043	163	37	the	the	DET
admet-2043	163	38	apical	apical	ADJ
admet-2043	163	39	surface	surface	NOUN
admet-2043	163	40	of	of	ADP
admet-2043	163	41	endothelial	endothelial	ADJ
admet-2043	163	42	cells	cell	NOUN
admet-2043	163	43	,	,	PUNCT
admet-2043	163	44	facilitated	facilitate	VERB
admet-2043	163	45	by	by	ADP
admet-2043	163	46	a	a	DET
admet-2043	163	47	diverse	diverse	ADJ
admet-2043	163	48	array	array	NOUN
admet-2043	163	49	of	of	ADP
admet-2043	163	50	ligands	ligand	NOUN
admet-2043	163	51	.	.	PUNCT
admet-2043	164	1	this	this	DET
admet-2043	164	2	interaction	interaction	NOUN
admet-2043	164	3	subsequently	subsequently	ADV
admet-2043	164	4	triggers	trigger	VERB
admet-2043	164	5	the	the	DET
admet-2043	164	6	internalisation	internalisation	NOUN
admet-2043	164	7	of	of	ADP
admet-2043	164	8	the	the	DET
admet-2043	164	9	nanoparticles	nanoparticle	NOUN
admet-2043	164	10	via	via	ADP
admet-2043	164	11	endocytosis	endocytosis	NOUN
admet-2043	164	12	.	.	PUNCT
admet-2043	165	1	in	in	ADP
admet-2043	165	2	a	a	DET
admet-2043	165	3	manner	manner	NOUN
admet-2043	165	4	akin	akin	ADJ
admet-2043	165	5	to	to	ADP
admet-2043	165	6	adsorptive	adsorptive	ADJ
admet-2043	165	7	-	-	PUNCT
admet-2043	165	8	mediated	mediate	VERB
admet-2043	165	9	transcytosis	transcytosis	NOUN
admet-2043	165	10	(	(	PUNCT
admet-2043	165	11	amt	amt	PROPN
admet-2043	165	12	)	)	PUNCT
admet-2043	165	13	,	,	PUNCT
admet-2043	165	14	the	the	DET
admet-2043	165	15	process	process	NOUN
admet-2043	165	16	of	of	ADP
admet-2043	165	17	intracellular	intracellular	ADJ
admet-2043	165	18	transport	transport	NOUN
admet-2043	165	19	vesicle	vesicle	NOUN
admet-2043	165	20	formation	formation	NOUN
admet-2043	165	21	involves	involve	VERB
admet-2043	165	22	the	the	DET
admet-2043	165	23	inward	inward	ADJ
admet-2043	165	24	folding	folding	NOUN
admet-2043	165	25	of	of	ADP
admet-2043	165	26	the	the	DET
admet-2043	165	27	cell	cell	NOUN
admet-2043	165	28	membrane	membrane	NOUN
admet-2043	165	29	,	,	PUNCT
admet-2043	165	30	facilitating	facilitate	VERB
admet-2043	165	31	the	the	DET
admet-2043	165	32	transportation	transportation	NOUN
admet-2043	165	33	of	of	ADP
admet-2043	165	34	nps	nps	PROPN
admet-2043	165	35	towards	towards	ADP
admet-2043	165	36	the	the	DET
admet-2043	165	37	basolateral	basolateral	ADJ
admet-2043	165	38	surface	surface	NOUN
admet-2043	166	1	[	[	X
admet-2043	166	2	45	45	NUM
admet-2043	166	3	]	]	PUNCT
admet-2043	166	4	.	.	PUNCT
admet-2043	167	1	nps	nps	PROPN
admet-2043	167	2	may	may	AUX
admet-2043	167	3	be	be	AUX
admet-2043	167	4	conjugated	conjugate	VERB
admet-2043	167	5	into	into	ADP
admet-2043	167	6	organic	organic	ADJ
admet-2043	167	7	or	or	CCONJ
admet-2043	167	8	synthetic	synthetic	ADJ
admet-2043	167	9	ligands	ligand	NOUN
admet-2043	167	10	,	,	PUNCT
admet-2043	167	11	and	and	CCONJ
admet-2043	167	12	rmt	rmt	NOUN
admet-2043	167	13	controls	control	VERB
admet-2043	167	14	the	the	DET
admet-2043	167	15	homeostasis	homeostasis	NOUN
admet-2043	167	16	of	of	ADP
admet-2043	167	17	nutrients	nutrient	NOUN
admet-2043	167	18	,	,	PUNCT
admet-2043	167	19	including	include	VERB
admet-2043	167	20	iron	iron	NOUN
admet-2043	167	21	,	,	PUNCT
admet-2043	167	22	insulin	insulin	NOUN
admet-2043	167	23	,	,	PUNCT
admet-2043	167	24	and	and	CCONJ
admet-2043	167	25	leptin	leptin	NOUN
admet-2043	167	26	.	.	PUNCT
admet-2043	168	1	these	these	DET
admet-2043	168	2	ligands	ligand	NOUN
admet-2043	168	3	serve	serve	VERB
admet-2043	168	4	as	as	ADP
admet-2043	168	5	np	np	PROPN
admet-2043	168	6	's	's	PART
admet-2043	168	7	"	"	PUNCT
admet-2043	168	8	trojan	trojan	NOUN
admet-2043	168	9	horses	horse	NOUN
admet-2043	168	10	"	"	PUNCT
admet-2043	168	11	to	to	PART
admet-2043	168	12	enter	enter	VERB
admet-2043	168	13	the	the	DET
admet-2043	168	14	brain	brain	NOUN
admet-2043	168	15	.	.	PUNCT
admet-2043	169	1	rmt	rmt	NOUN
admet-2043	169	2	makes	make	VERB
admet-2043	169	3	it	it	PRON
admet-2043	169	4	possible	possible	ADJ
admet-2043	169	5	to	to	PART
admet-2043	169	6	precisely	precisely	ADV
admet-2043	169	7	target	target	VERB
admet-2043	169	8	tumour	tumour	NOUN
admet-2043	169	9	cells	cell	NOUN
admet-2043	169	10	and	and	CCONJ
admet-2043	169	11	brain	brain	NOUN
admet-2043	169	12	tissue	tissue	NOUN
admet-2043	169	13	[	[	X
admet-2043	169	14	46	46	NUM
admet-2043	169	15	]	]	PUNCT
admet-2043	169	16	.	.	PUNCT
admet-2043	170	1	by	by	ADP
admet-2043	170	2	developing	develop	VERB
admet-2043	170	3	ligands	ligand	NOUN
admet-2043	170	4	that	that	PRON
admet-2043	170	5	can	can	AUX
admet-2043	170	6	bind	bind	VERB
admet-2043	170	7	to	to	ADP
admet-2043	170	8	receptors	receptor	NOUN
admet-2043	170	9	on	on	ADP
admet-2043	170	10	the	the	DET
admet-2043	170	11	apical	apical	ADJ
admet-2043	170	12	surface	surface	NOUN
admet-2043	170	13	of	of	ADP
admet-2043	170	14	bbb	bbb	PROPN
admet-2043	170	15	endothelial	endothelial	NOUN
admet-2043	170	16	cells	cell	NOUN
admet-2043	170	17	as	as	ADV
admet-2043	170	18	well	well	ADV
admet-2043	170	19	as	as	ADP
admet-2043	170	20	target	target	NOUN
admet-2043	170	21	tissue	tissue	NOUN
admet-2043	170	22	,	,	PUNCT
admet-2043	170	23	such	such	ADJ
admet-2043	170	24	as	as	ADP
admet-2043	170	25	transferrin	transferrin	NOUN
admet-2043	170	26	and	and	CCONJ
admet-2043	170	27	low	low	ADJ
admet-2043	170	28	-	-	PUNCT
admet-2043	170	29	density	density	NOUN
admet-2043	170	30	lipoprotein	lipoprotein	ADJ
admet-2043	170	31	receptors	receptor	NOUN
admet-2043	170	32	,	,	PUNCT
admet-2043	170	33	which	which	PRON
admet-2043	170	34	are	be	AUX
admet-2043	170	35	found	find	VERB
admet-2043	170	36	at	at	ADP
admet-2043	170	37	the	the	DET
admet-2043	170	38	bbb	bbb	NOUN
admet-2043	170	39	and	and	CCONJ
admet-2043	170	40	are	be	AUX
admet-2043	170	41	overexpressed	overexpresse	VERB
admet-2043	170	42	in	in	ADP
admet-2043	170	43	cancer	cancer	NOUN
admet-2043	170	44	cells	cell	NOUN
admet-2043	170	45	,	,	PUNCT
admet-2043	170	46	nps	nps	PROPN
admet-2043	170	47	may	may	AUX
admet-2043	170	48	be	be	AUX
admet-2043	170	49	directed	direct	VERB
admet-2043	170	50	to	to	ADP
admet-2043	170	51	particular	particular	ADJ
admet-2043	170	52	brain	brain	NOUN
admet-2043	170	53	areas	area	NOUN
admet-2043	170	54	[	[	X
admet-2043	170	55	47	47	NUM
admet-2043	170	56	]	]	PUNCT
admet-2043	170	57	.	.	PUNCT
admet-2043	171	1	liang	liang	PROPN
admet-2043	172	1	[	[	X
admet-2043	172	2	48	48	NUM
admet-2043	172	3	]	]	PUNCT
admet-2043	172	4	et	et	PROPN
admet-2043	172	5	al	al	PROPN
admet-2043	172	6	.	.	PROPN
admet-2043	172	7	,	,	PUNCT
admet-2043	172	8	for	for	ADP
admet-2043	172	9	instance	instance	NOUN
admet-2043	172	10	,	,	PUNCT
admet-2043	172	11	established	establish	VERB
admet-2043	172	12	in	in	ADP
admet-2043	172	13	mice	mouse	NOUN
admet-2043	172	14	that	that	SCONJ
admet-2043	172	15	the	the	DET
admet-2043	172	16	chemotherapeutic	chemotherapeutic	ADJ
admet-2043	172	17	vincristine	vincristine	NOUN
admet-2043	172	18	sulphate	sulphate	NOUN
admet-2043	172	19	may	may	AUX
admet-2043	172	20	specifically	specifically	ADV
admet-2043	172	21	bind	bind	VERB
admet-2043	172	22	the	the	DET
admet-2043	172	23	ldl	ldl	NOUN
admet-2043	172	24	receptor	receptor	NOUN
admet-2043	172	25	and	and	CCONJ
admet-2043	172	26	target	target	VERB
admet-2043	172	27	glioma	glioma	NOUN
admet-2043	172	28	cells	cell	NOUN
admet-2043	172	29	via	via	ADP
admet-2043	172	30	conjugating	conjugate	VERB
admet-2043	172	31	ldl	ldl	NOUN
admet-2043	172	32	(	(	PUNCT
admet-2043	172	33	low	low	ADJ
admet-2043	172	34	-	-	PUNCT
admet-2043	172	35	density	density	NOUN
admet-2043	172	36	lipoprotein	lipoprotein	ADJ
admet-2043	172	37	)	)	PUNCT
admet-2043	172	38	particles	particle	NOUN
admet-2043	172	39	.	.	PUNCT
admet-2043	173	1	however	however	ADV
admet-2043	173	2	,	,	PUNCT
admet-2043	173	3	excessive	excessive	ADJ
admet-2043	173	4	avidity	avidity	NOUN
admet-2043	173	5	of	of	ADP
admet-2043	173	6	nps	nps	PROPN
admet-2043	173	7	may	may	AUX
admet-2043	173	8	prevent	prevent	VERB
admet-2043	173	9	them	they	PRON
admet-2043	173	10	from	from	ADP
admet-2043	173	11	dissociating	dissociate	VERB
admet-2043	173	12	from	from	ADP
admet-2043	173	13	their	their	PRON
admet-2043	173	14	receptor	receptor	NOUN
admet-2043	173	15	and	and	CCONJ
admet-2043	173	16	keep	keep	VERB
admet-2043	173	17	them	they	PRON
admet-2043	173	18	attached	attach	VERB
admet-2043	173	19	to	to	ADP
admet-2043	173	20	endothelial	endothelial	ADJ
admet-2043	173	21	cells	cell	NOUN
admet-2043	173	22	,	,	PUNCT
admet-2043	173	23	which	which	PRON
admet-2043	173	24	is	be	AUX
admet-2043	173	25	a	a	DET
admet-2043	173	26	significant	significant	ADJ
admet-2043	173	27	problem	problem	NOUN
admet-2043	173	28	when	when	SCONJ
admet-2043	173	29	designing	design	VERB
admet-2043	173	30	nps	nps	PROPN
admet-2043	173	31	and	and	CCONJ
admet-2043	173	32	conjugating	conjugating	ADJ
admet-2043	173	33	ligands	ligand	NOUN
admet-2043	173	34	[	[	X
admet-2043	173	35	47	47	NUM
admet-2043	173	36	]	]	PUNCT
admet-2043	173	37	.	.	PUNCT
admet-2043	174	1	in	in	ADP
admet-2043	174	2	brain	brain	NOUN
admet-2043	174	3	cancer	cancer	NOUN
admet-2043	174	4	cells	cell	NOUN
admet-2043	174	5	,	,	PUNCT
admet-2043	174	6	doxorubicin	doxorubicin	PROPN
admet-2043	174	7	-	-	PUNCT
admet-2043	174	8	loaded	load	VERB
admet-2043	174	9	polysorbate	polysorbate	NOUN
admet-2043	174	10	80	80	NUM
admet-2043	174	11	-	-	PUNCT
admet-2043	174	12	coated	coat	VERB
admet-2043	174	13	nps	nps	PROPN
admet-2043	174	14	greatly	greatly	ADV
admet-2043	174	15	increased	increase	VERB
admet-2043	174	16	caspase-3	caspase-3	NUM
admet-2043	174	17	expression	expression	NOUN
admet-2043	174	18	and	and	CCONJ
admet-2043	174	19	death	death	NOUN
admet-2043	174	20	,	,	PUNCT
admet-2043	174	21	which	which	PRON
admet-2043	174	22	inhibited	inhibit	VERB
admet-2043	174	23	metastasis	metastasis	NOUN
admet-2043	174	24	and	and	CCONJ
admet-2043	174	25	prolonged	prolonged	ADJ
admet-2043	174	26	survival	survival	NOUN
admet-2043	174	27	[	[	X
admet-2043	174	28	49	49	NUM
admet-2043	174	29	]	]	PUNCT
admet-2043	174	30	.	.	PUNCT
admet-2043	175	1	receptor	receptor	NOUN
admet-2043	175	2	-	-	PUNCT
admet-2043	175	3	mediated	mediate	VERB
admet-2043	175	4	transportation	transportation	NOUN
admet-2043	175	5	(	(	PUNCT
admet-2043	175	6	rmt	rmt	NOUN
admet-2043	175	7	)	)	PUNCT
admet-2043	175	8	is	be	AUX
admet-2043	175	9	a	a	DET
admet-2043	175	10	technology	technology	NOUN
admet-2043	175	11	that	that	PRON
admet-2043	175	12	enables	enable	VERB
admet-2043	175	13	precise	precise	ADJ
admet-2043	175	14	targeting	targeting	NOUN
admet-2043	175	15	of	of	ADP
admet-2043	175	16	brain	brain	NOUN
admet-2043	175	17	tissue	tissue	NOUN
admet-2043	175	18	and	and	CCONJ
admet-2043	175	19	tumour	tumour	NOUN
admet-2043	175	20	cells	cell	NOUN
admet-2043	175	21	,	,	PUNCT
admet-2043	175	22	as	as	ADV
admet-2043	175	23	well	well	ADV
admet-2043	175	24	as	as	ADP
admet-2043	175	25	the	the	DET
admet-2043	175	26	capacity	capacity	NOUN
admet-2043	175	27	to	to	PART
admet-2043	175	28	maintain	maintain	VERB
admet-2043	175	29	nutritional	nutritional	ADJ
admet-2043	175	30	homeostasis	homeostasis	NOUN
admet-2043	175	31	and	and	CCONJ
admet-2043	175	32	employ	employ	VERB
admet-2043	175	33	ligands	ligand	NOUN
admet-2043	175	34	as	as	ADP
admet-2043	175	35	"	"	PUNCT
admet-2043	175	36	trojan	trojan	NOUN
admet-2043	175	37	horses	horse	NOUN
admet-2043	175	38	"	"	PUNCT
admet-2043	175	39	for	for	ADP
admet-2043	175	40	nanoparticle	nanoparticle	NOUN
admet-2043	175	41	entry	entry	NOUN
admet-2043	175	42	into	into	ADP
admet-2043	175	43	the	the	DET
admet-2043	175	44	brain	brain	NOUN
admet-2043	176	1	[	[	X
admet-2043	176	2	50	50	NUM
admet-2043	176	3	]	]	PUNCT
admet-2043	176	4	.	.	PUNCT
admet-2043	177	1	despite	despite	SCONJ
admet-2043	177	2	the	the	DET
admet-2043	177	3	benefits	benefit	NOUN
admet-2043	177	4	of	of	ADP
admet-2043	177	5	using	use	VERB
admet-2043	177	6	rmt	rmt	NOUN
admet-2043	177	7	to	to	PART
admet-2043	177	8	deliver	deliver	VERB
admet-2043	177	9	drugs	drug	NOUN
admet-2043	177	10	via	via	ADP
admet-2043	177	11	the	the	DET
admet-2043	177	12	bbb	bbb	PROPN
admet-2043	177	13	,	,	PUNCT
admet-2043	177	14	certain	certain	ADJ
admet-2043	177	15	disadvantages	disadvantage	NOUN
admet-2043	177	16	need	need	VERB
admet-2043	177	17	to	to	PART
admet-2043	177	18	be	be	AUX
admet-2043	177	19	considered	consider	VERB
admet-2043	177	20	.	.	PUNCT
admet-2043	178	1	one	one	NUM
admet-2043	178	2	drawback	drawback	NOUN
admet-2043	178	3	is	be	AUX
admet-2043	178	4	the	the	DET
admet-2043	178	5	possibility	possibility	NOUN
admet-2043	178	6	of	of	ADP
admet-2043	178	7	excessive	excessive	ADJ
admet-2043	178	8	avidity	avidity	NOUN
admet-2043	178	9	,	,	PUNCT
admet-2043	178	10	resulting	result	VERB
admet-2043	178	11	in	in	ADP
admet-2043	178	12	nps	nps	PROPN
admet-2043	178	13	remaining	remain	VERB
admet-2043	178	14	attached	attach	VERB
admet-2043	178	15	to	to	ADP
admet-2043	178	16	endothelial	endothelial	ADJ
admet-2043	178	17	cells	cell	NOUN
admet-2043	178	18	instead	instead	ADV
admet-2043	178	19	of	of	ADP
admet-2043	178	20	detaching	detach	VERB
admet-2043	178	21	from	from	ADP
admet-2043	178	22	their	their	PRON
admet-2043	178	23	receptors	receptor	NOUN
admet-2043	178	24	,	,	PUNCT
admet-2043	178	25	leading	lead	VERB
admet-2043	178	26	to	to	ADP
admet-2043	178	27	inefficient	inefficient	ADJ
admet-2043	178	28	drug	drug	NOUN
admet-2043	178	29	delivery	delivery	NOUN
admet-2043	178	30	.	.	PUNCT
admet-2043	179	1	this	this	PRON
admet-2043	179	2	emphasizes	emphasize	VERB
admet-2043	179	3	the	the	DET
admet-2043	179	4	importance	importance	NOUN
admet-2043	179	5	of	of	ADP
admet-2043	179	6	careful	careful	ADJ
admet-2043	179	7	design	design	NOUN
admet-2043	179	8	and	and	CCONJ
admet-2043	179	9	ligand	ligand	ADJ
admet-2043	179	10	conjugation	conjugation	NOUN
admet-2043	179	11	strategies	strategy	NOUN
admet-2043	179	12	to	to	PART
admet-2043	179	13	optimize	optimize	VERB
admet-2043	179	14	the	the	DET
admet-2043	179	15	detachment	detachment	NOUN
admet-2043	179	16	of	of	ADP
admet-2043	179	17	nps	nps	PROPN
admet-2043	179	18	from	from	ADP
admet-2043	179	19	receptors	receptor	NOUN
admet-2043	179	20	[	[	X
admet-2043	179	21	51	51	NUM
admet-2043	179	22	]	]	PUNCT
admet-2043	179	23	.	.	PUNCT
admet-2043	180	1	additionally	additionally	ADV
admet-2043	180	2	,	,	PUNCT
admet-2043	180	3	the	the	DET
admet-2043	180	4	design	design	NOUN
admet-2043	180	5	and	and	CCONJ
admet-2043	180	6	optimization	optimization	NOUN
admet-2043	180	7	of	of	ADP
admet-2043	180	8	rmt	rmt	NOUN
admet-2043	180	9	systems	system	NOUN
admet-2043	180	10	can	can	AUX
admet-2043	180	11	be	be	AUX
admet-2043	180	12	complex	complex	ADJ
admet-2043	180	13	,	,	PUNCT
admet-2043	180	14	requiring	require	VERB
admet-2043	180	15	meticulous	meticulous	ADJ
admet-2043	180	16	selection	selection	NOUN
admet-2043	180	17	and	and	CCONJ
admet-2043	180	18	conjugation	conjugation	NOUN
admet-2043	180	19	of	of	ADP
admet-2043	180	20	ligands	ligand	NOUN
admet-2043	180	21	to	to	PART
admet-2043	180	22	ensure	ensure	VERB
admet-2043	180	23	proper	proper	ADJ
admet-2043	180	24	ligand	ligand	NOUN
admet-2043	180	25	-	-	PUNCT
admet-2043	180	26	receptor	receptor	NOUN
admet-2043	180	27	interactions	interaction	NOUN
admet-2043	180	28	.	.	PUNCT
admet-2043	181	1	transporter	transporter	NOUN
admet-2043	181	2	-	-	PUNCT
admet-2043	181	3	mediated	mediate	VERB
admet-2043	181	4	transport	transport	NOUN
admet-2043	181	5	the	the	DET
admet-2043	181	6	bbb	bbb	PROPN
admet-2043	181	7	is	be	AUX
admet-2043	181	8	a	a	DET
admet-2043	181	9	strongly	strongly	ADV
admet-2043	181	10	expressed	express	VERB
admet-2043	181	11	transporter	transporter	NOUN
admet-2043	181	12	of	of	ADP
admet-2043	181	13	nutrients	nutrient	NOUN
admet-2043	181	14	that	that	PRON
admet-2043	181	15	the	the	DET
admet-2043	181	16	brain	brain	NOUN
admet-2043	181	17	needs	need	VERB
admet-2043	181	18	.	.	PUNCT
admet-2043	182	1	researchers	researcher	NOUN
admet-2043	182	2	have	have	AUX
admet-2043	182	3	coupled	couple	VERB
admet-2043	182	4	glutathione	glutathione	NOUN
admet-2043	182	5	,	,	PUNCT
admet-2043	182	6	an	an	DET
admet-2043	182	7	endogenous	endogenous	ADJ
admet-2043	182	8	tripeptide	tripeptide	ADV
admet-2043	182	9	with	with	ADP
admet-2043	182	10	antioxidant	antioxidant	ADJ
admet-2043	182	11	characteristics	characteristic	NOUN
admet-2043	182	12	,	,	PUNCT
admet-2043	182	13	onto	onto	ADP
admet-2043	182	14	liposomes	liposome	NOUN
admet-2043	182	15	to	to	PART
admet-2043	182	16	transport	transport	VERB
admet-2043	182	17	multiple	multiple	ADJ
admet-2043	182	18	medications	medication	NOUN
admet-2043	182	19	to	to	ADP
admet-2043	182	20	the	the	DET
admet-2043	182	21	brain	brain	NOUN
admet-2043	182	22	.	.	PUNCT
admet-2043	183	1	li	li	PROPN
admet-2043	183	2	.	.	PUNCT
admet-2043	184	1	[	[	X
admet-2043	184	2	52	52	NUM
admet-2043	184	3	]	]	PUNCT
admet-2043	184	4	et	et	PROPN
admet-2043	184	5	al	al	PROPN
admet-2043	184	6	.	.	PROPN
admet-2043	184	7	created	create	VERB
admet-2043	184	8	a	a	DET
admet-2043	184	9	number	number	NOUN
admet-2043	184	10	of	of	ADP
admet-2043	184	11	bis	bis	ADJ
admet-2043	184	12	-	-	ADJ
admet-2043	184	13	quaternary	quaternary	ADJ
admet-2043	184	14	ammonium	ammonium	NOUN
admet-2043	184	15	compounds	compound	NOUN
admet-2043	184	16	with	with	ADP
admet-2043	184	17	high	high	ADJ
admet-2043	184	18	affinity	affinity	NOUN
admet-2043	184	19	for	for	ADP
admet-2043	184	20	the	the	DET
admet-2043	184	21	choline	choline	NOUN
admet-2043	184	22	transporter	transporter	NOUN
admet-2043	184	23	,	,	PUNCT
admet-2043	184	24	and	and	CCONJ
admet-2043	184	25	an	an	DET
admet-2043	184	26	in	in	ADP
admet-2043	184	27	vitro	vitro	X
admet-2043	184	28	investigation	investigation	NOUN
admet-2043	184	29	found	find	VERB
admet-2043	184	30	that	that	SCONJ
admet-2043	184	31	modification	modification	NOUN
admet-2043	184	32	with	with	ADP
admet-2043	184	33	a	a	DET
admet-2043	184	34	choline	choline	NOUN
admet-2043	184	35	derivative	derivative	NOUN
admet-2043	184	36	allowed	allow	VERB
admet-2043	184	37	for	for	ADP
admet-2043	184	38	more	more	ADV
admet-2043	184	39	effective	effective	ADJ
admet-2043	184	40	absorption	absorption	NOUN
admet-2043	184	41	by	by	ADP
admet-2043	184	42	bcec	bcec	NOUN
admet-2043	184	43	in	in	ADP
admet-2043	184	44	comparison	comparison	NOUN
admet-2043	184	45	to	to	ADP
admet-2043	184	46	untreated	untreated	ADJ
admet-2043	184	47	dendrimers	dendrimer	NOUN
admet-2043	184	48	.	.	PUNCT
admet-2043	185	1	the	the	DET
admet-2043	185	2	same	same	ADJ
admet-2043	185	3	drug	drug	NOUN
admet-2043	185	4	delivery	delivery	NOUN
admet-2043	185	5	method	method	NOUN
admet-2043	185	6	was	be	AUX
admet-2043	185	7	also	also	ADV
admet-2043	185	8	employed	employ	VERB
admet-2043	185	9	to	to	PART
admet-2043	185	10	administer	administer	VERB
admet-2043	185	11	the	the	DET
admet-2043	185	12	mri	mri	NOUN
admet-2043	185	13	contrast	contrast	NOUN
admet-2043	185	14	agent	agent	NOUN
admet-2043	185	15	gd	gd	PROPN
admet-2043	185	16	,	,	PUNCT
admet-2043	185	17	dna	dna	PROPN
admet-2043	185	18	,	,	PUNCT
admet-2043	185	19	and	and	CCONJ
admet-2043	185	20	doxorubicin	doxorubicin	PROPN
admet-2043	185	21	,	,	PUNCT
admet-2043	185	22	demonstrating	demonstrate	VERB
admet-2043	185	23	good	good	ADJ
admet-2043	185	24	brain	brain	NOUN
admet-2043	185	25	-	-	PUNCT
admet-2043	185	26	targeted	target	VERB
admet-2043	185	27	delivery	delivery	NOUN
admet-2043	185	28	effectiveness	effectiveness	NOUN
admet-2043	185	29	[	[	X
admet-2043	185	30	49	49	NUM
admet-2043	185	31	]	]	PUNCT
admet-2043	185	32	.	.	PUNCT
admet-2043	186	1	transporter	transporter	NOUN
admet-2043	186	2	-	-	PUNCT
admet-2043	186	3	mediated	mediate	VERB
admet-2043	186	4	transport	transport	NOUN
admet-2043	186	5	for	for	ADP
admet-2043	186	6	medication	medication	NOUN
admet-2043	186	7	administration	administration	NOUN
admet-2043	186	8	across	across	ADP
admet-2043	186	9	the	the	DET
admet-2043	186	10	blood	blood	NOUN
admet-2043	186	11	-	-	PUNCT
admet-2043	186	12	brain	brain	NOUN
admet-2043	186	13	barrier	barrier	NOUN
admet-2043	186	14	offers	offer	VERB
admet-2043	186	15	various	various	ADJ
admet-2043	186	16	advantages	advantage	NOUN
admet-2043	186	17	.	.	PUNCT
admet-2043	187	1	by	by	ADP
admet-2043	187	2	boosting	boost	VERB
admet-2043	187	3	absorption	absorption	NOUN
admet-2043	187	4	and	and	CCONJ
admet-2043	187	5	transport	transport	NOUN
admet-2043	187	6	,	,	PUNCT
admet-2043	187	7	it	it	PRON
admet-2043	187	8	enhances	enhance	VERB
admet-2043	187	9	medication	medication	NOUN
admet-2043	187	10	delivery	delivery	NOUN
admet-2043	187	11	to	to	ADP
admet-2043	187	12	the	the	DET
admet-2043	187	13	brain	brain	NOUN
admet-2043	187	14	,	,	PUNCT
admet-2043	187	15	enhancing	enhance	VERB
admet-2043	187	16	therapeutic	therapeutic	ADJ
admet-2043	187	17	effectiveness	effectiveness	NOUN
admet-2043	187	18	.	.	PUNCT
admet-2043	188	1	it	it	PRON
admet-2043	188	2	also	also	ADV
admet-2043	188	3	allows	allow	VERB
admet-2043	188	4	for	for	ADP
admet-2043	188	5	targeted	target	VERB
admet-2043	188	6	distribution	distribution	NOUN
admet-2043	188	7	by	by	ADP
admet-2043	188	8	utilising	utilise	VERB
admet-2043	188	9	transporters	transporter	NOUN
admet-2043	188	10	that	that	PRON
admet-2043	188	11	are	be	AUX
admet-2043	188	12	abundant	abundant	ADJ
admet-2043	188	13	on	on	ADP
admet-2043	188	14	the	the	DET
admet-2043	188	15	bbb	bbb	NOUN
admet-2043	189	1	[	[	X
admet-2043	189	2	53	53	NUM
admet-2043	189	3	]	]	PUNCT
admet-2043	189	4	.	.	PUNCT
admet-2043	190	1	however	however	ADV
admet-2043	190	2	,	,	PUNCT
admet-2043	190	3	there	there	PRON
admet-2043	190	4	are	be	VERB
admet-2043	190	5	certain	certain	ADJ
admet-2043	190	6	challenges	challenge	NOUN
admet-2043	190	7	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	190	8	m.	m.	NOUN
admet-2043	191	1	kulkarni	kulkarni	PROPN
admet-2043	191	2	et	et	PROPN
admet-2043	191	3	al	al	PROPN
admet-2043	191	4	.	.	PROPN
admet-2043	191	5	admet	admet	PROPN
admet-2043	191	6	&	&	CCONJ
admet-2043	191	7	dmpk	dmpk	PROPN
admet-2043	191	8	12(1	12(1	PROPN
admet-2043	191	9	)	)	PUNCT
admet-2043	191	10	(	(	PUNCT
admet-2043	191	11	2024	2024	NUM
admet-2043	191	12	)	)	PUNCT
admet-2043	191	13	63	63	NUM
admet-2043	191	14	-	-	SYM
admet-2043	191	15	105	105	NUM
admet-2043	191	16	72	72	NUM
admet-2043	191	17	associated	associate	VERB
admet-2043	191	18	with	with	ADP
admet-2043	191	19	transporter	transporter	NOUN
admet-2043	191	20	-	-	PUNCT
admet-2043	191	21	mediated	mediate	VERB
admet-2043	191	22	transport	transport	NOUN
admet-2043	191	23	,	,	PUNCT
admet-2043	191	24	including	include	VERB
admet-2043	191	25	the	the	DET
admet-2043	191	26	complexity	complexity	NOUN
admet-2043	191	27	of	of	ADP
admet-2043	191	28	system	system	NOUN
admet-2043	191	29	design	design	NOUN
admet-2043	191	30	and	and	CCONJ
admet-2043	191	31	optimisation	optimisation	NOUN
admet-2043	191	32	,	,	PUNCT
admet-2043	191	33	the	the	DET
admet-2043	191	34	limited	limited	ADJ
admet-2043	191	35	availability	availability	NOUN
admet-2043	191	36	and	and	CCONJ
admet-2043	191	37	selectivity	selectivity	NOUN
admet-2043	191	38	of	of	ADP
admet-2043	191	39	some	some	DET
admet-2043	191	40	transporters	transporter	NOUN
admet-2043	191	41	,	,	PUNCT
admet-2043	191	42	and	and	CCONJ
admet-2043	191	43	the	the	DET
admet-2043	191	44	possibility	possibility	NOUN
admet-2043	191	45	of	of	ADP
admet-2043	191	46	off	off	ADP
admet-2043	191	47	-	-	PUNCT
admet-2043	191	48	target	target	NOUN
admet-2043	191	49	effects	effect	NOUN
admet-2043	191	50	due	due	ADJ
admet-2043	191	51	to	to	ADP
admet-2043	191	52	expression	expression	NOUN
admet-2043	191	53	in	in	ADP
admet-2043	191	54	other	other	ADJ
admet-2043	191	55	tissues	tissue	NOUN
admet-2043	191	56	or	or	CCONJ
admet-2043	191	57	organs	organ	NOUN
admet-2043	191	58	[	[	PUNCT
admet-2043	191	59	54	54	NUM
admet-2043	191	60	]	]	PUNCT
admet-2043	191	61	.	.	PUNCT
admet-2043	192	1	overall	overall	ADJ
admet-2043	192	2	,	,	PUNCT
admet-2043	192	3	transporter	transporter	NOUN
admet-2043	192	4	-	-	PUNCT
admet-2043	192	5	mediated	mediate	VERB
admet-2043	192	6	transport	transport	NOUN
admet-2043	192	7	has	have	VERB
admet-2043	192	8	the	the	DET
admet-2043	192	9	potential	potential	NOUN
admet-2043	192	10	to	to	PART
admet-2043	192	11	improve	improve	VERB
admet-2043	192	12	brain	brain	NOUN
admet-2043	192	13	drug	drug	NOUN
admet-2043	192	14	delivery	delivery	NOUN
admet-2043	192	15	,	,	PUNCT
admet-2043	192	16	but	but	CCONJ
admet-2043	192	17	careful	careful	ADJ
admet-2043	192	18	thinking	thinking	NOUN
admet-2043	192	19	and	and	CCONJ
admet-2043	192	20	additional	additional	ADJ
admet-2043	192	21	study	study	NOUN
admet-2043	192	22	are	be	AUX
admet-2043	192	23	required	require	VERB
admet-2043	192	24	to	to	PART
admet-2043	192	25	overcome	overcome	VERB
admet-2043	192	26	these	these	DET
admet-2043	192	27	obstacles	obstacle	NOUN
admet-2043	192	28	and	and	CCONJ
admet-2043	192	29	maximise	maximise	VERB
admet-2043	192	30	its	its	PRON
admet-2043	192	31	potential	potential	NOUN
admet-2043	192	32	[	[	X
admet-2043	192	33	55	55	NUM
admet-2043	192	34	]	]	PUNCT
admet-2043	192	35	.	.	PUNCT
admet-2043	193	1	adsorptive	adsorptive	ADJ
admet-2043	193	2	-	-	PUNCT
admet-2043	193	3	mediated	mediate	VERB
admet-2043	193	4	transportation	transportation	NOUN
admet-2043	193	5	nps	nps	PROPN
admet-2043	193	6	are	be	AUX
admet-2043	193	7	often	often	ADV
admet-2043	193	8	transported	transport	VERB
admet-2043	193	9	across	across	ADP
admet-2043	193	10	the	the	DET
admet-2043	193	11	bbb	bbb	NOUN
admet-2043	193	12	through	through	ADP
admet-2043	193	13	adsorption	adsorption	NOUN
admet-2043	193	14	or	or	CCONJ
admet-2043	193	15	receptor	receptor	NOUN
admet-2043	193	16	-	-	PUNCT
admet-2043	193	17	mediated	mediate	VERB
admet-2043	193	18	transcytosis	transcytosis	NOUN
admet-2043	193	19	in	in	ADP
admet-2043	193	20	endothelial	endothelial	ADJ
admet-2043	193	21	cells	cell	NOUN
admet-2043	193	22	[	[	X
admet-2043	193	23	56	56	NUM
admet-2043	193	24	]	]	PUNCT
admet-2043	193	25	.	.	PUNCT
admet-2043	194	1	adsorptive	adsorptive	ADJ
admet-2043	194	2	-	-	PUNCT
admet-2043	194	3	mediated	mediate	VERB
admet-2043	194	4	transcytosis	transcytosis	NOUN
admet-2043	194	5	(	(	PUNCT
admet-2043	194	6	amt	amt	PROPN
admet-2043	194	7	)	)	PUNCT
admet-2043	194	8	is	be	AUX
admet-2043	194	9	a	a	DET
admet-2043	194	10	mechanism	mechanism	NOUN
admet-2043	194	11	that	that	PRON
admet-2043	194	12	results	result	VERB
admet-2043	194	13	in	in	ADP
admet-2043	194	14	vesicle	vesicle	NOUN
admet-2043	194	15	production	production	NOUN
admet-2043	194	16	and	and	CCONJ
admet-2043	194	17	cell	cell	NOUN
admet-2043	194	18	membrane	membrane	NOUN
admet-2043	194	19	invasion	invasion	NOUN
admet-2043	194	20	as	as	ADP
admet-2043	194	21	a	a	DET
admet-2043	194	22	result	result	NOUN
admet-2043	194	23	of	of	ADP
admet-2043	194	24	connections	connection	NOUN
admet-2043	194	25	between	between	ADP
admet-2043	194	26	nanoparticles	nanoparticle	NOUN
admet-2043	194	27	and	and	CCONJ
admet-2043	194	28	the	the	DET
admet-2043	194	29	endothelial	endothelial	ADJ
admet-2043	194	30	plasma	plasma	NOUN
admet-2043	194	31	membrane	membrane	NOUN
admet-2043	194	32	.	.	PUNCT
admet-2043	195	1	endosomes	endosome	NOUN
admet-2043	195	2	are	be	AUX
admet-2043	195	3	created	create	VERB
admet-2043	195	4	to	to	PART
admet-2043	195	5	transfer	transfer	VERB
admet-2043	195	6	nanoparticles	nanoparticle	NOUN
admet-2043	195	7	directly	directly	ADV
admet-2043	195	8	to	to	ADP
admet-2043	195	9	the	the	DET
admet-2043	195	10	basolateral	basolateral	ADJ
admet-2043	195	11	surface	surface	NOUN
admet-2043	195	12	,	,	PUNCT
admet-2043	195	13	lysosomes	lysosome	VERB
admet-2043	195	14	for	for	ADP
admet-2043	195	15	degradation	degradation	NOUN
admet-2043	195	16	,	,	PUNCT
admet-2043	195	17	or	or	CCONJ
admet-2043	195	18	the	the	DET
admet-2043	195	19	apical	apical	ADJ
admet-2043	195	20	plasma	plasma	NOUN
admet-2043	195	21	membrane	membrane	NOUN
admet-2043	196	1	[	[	X
admet-2043	196	2	57	57	NUM
admet-2043	196	3	]	]	PUNCT
admet-2043	196	4	.	.	PUNCT
admet-2043	196	5	adsorptive	adsorptive	ADJ
admet-2043	196	6	-	-	PUNCT
admet-2043	196	7	mediated	mediate	VERB
admet-2043	196	8	transcytosis	transcytosis	NOUN
admet-2043	196	9	(	(	PUNCT
admet-2043	196	10	amt	amt	PROPN
admet-2043	196	11	)	)	PUNCT
admet-2043	196	12	is	be	AUX
admet-2043	196	13	a	a	DET
admet-2043	196	14	non	non	ADJ
admet-2043	196	15	-	-	ADJ
admet-2043	196	16	receptor	receptor	NOUN
admet-2043	196	17	-	-	PUNCT
admet-2043	196	18	mediated	mediate	VERB
admet-2043	196	19	mechanism	mechanism	NOUN
admet-2043	196	20	for	for	ADP
admet-2043	196	21	nanoparticle	nanoparticle	NOUN
admet-2043	196	22	(	(	PUNCT
admet-2043	196	23	np	np	INTJ
admet-2043	196	24	)	)	PUNCT
admet-2043	196	25	transport	transport	NOUN
admet-2043	196	26	across	across	ADP
admet-2043	196	27	the	the	DET
admet-2043	196	28	blood	blood	NOUN
admet-2043	196	29	-	-	PUNCT
admet-2043	196	30	brain	brain	NOUN
admet-2043	196	31	barrier	barrier	NOUN
admet-2043	196	32	(	(	PUNCT
admet-2043	196	33	bbb	bbb	PROPN
admet-2043	196	34	)	)	PUNCT
admet-2043	196	35	.	.	PUNCT
admet-2043	197	1	it	it	PRON
admet-2043	197	2	provides	provide	VERB
admet-2043	197	3	an	an	DET
admet-2043	197	4	improved	improved	ADJ
admet-2043	197	5	channel	channel	NOUN
admet-2043	197	6	for	for	ADP
admet-2043	197	7	delivering	deliver	VERB
admet-2043	197	8	nps	nps	PROPN
admet-2043	197	9	to	to	ADP
admet-2043	197	10	the	the	DET
admet-2043	197	11	brain	brain	NOUN
admet-2043	197	12	,	,	PUNCT
admet-2043	197	13	allowing	allow	VERB
admet-2043	197	14	therapeutic	therapeutic	ADJ
admet-2043	197	15	,	,	PUNCT
admet-2043	197	16	imaging	imaging	NOUN
admet-2043	197	17	,	,	PUNCT
admet-2043	197	18	and	and	CCONJ
admet-2043	197	19	diagnostic	diagnostic	ADJ
admet-2043	197	20	nanoparticles	nanoparticle	NOUN
admet-2043	197	21	to	to	PART
admet-2043	197	22	be	be	AUX
admet-2043	197	23	delivered	deliver	VERB
admet-2043	197	24	.	.	PUNCT
admet-2043	198	1	electrostatic	electrostatic	ADJ
admet-2043	198	2	interactions	interaction	NOUN
admet-2043	198	3	between	between	ADP
admet-2043	198	4	cationic	cationic	ADJ
admet-2043	198	5	nps	nps	PROPN
admet-2043	198	6	and	and	CCONJ
admet-2043	198	7	anionic	anionic	ADJ
admet-2043	198	8	endothelial	endothelial	NOUN
admet-2043	198	9	cell	cell	NOUN
admet-2043	198	10	membranes	membrane	NOUN
admet-2043	198	11	frequently	frequently	ADV
admet-2043	198	12	promote	promote	VERB
admet-2043	198	13	np	np	INTJ
admet-2043	198	14	binding	bind	VERB
admet-2043	198	15	,	,	PUNCT
admet-2043	198	16	internalisation	internalisation	NOUN
admet-2043	198	17	,	,	PUNCT
admet-2043	198	18	and	and	CCONJ
admet-2043	198	19	transit	transit	NOUN
admet-2043	198	20	across	across	ADP
admet-2043	198	21	the	the	DET
admet-2043	198	22	bbb	bbb	NOUN
admet-2043	199	1	[	[	X
admet-2043	199	2	58	58	NUM
admet-2043	199	3	]	]	PUNCT
admet-2043	199	4	.	.	PUNCT
admet-2043	200	1	however	however	ADV
admet-2043	200	2	,	,	PUNCT
admet-2043	200	3	due	due	ADP
admet-2043	200	4	to	to	ADP
admet-2043	200	5	its	its	PRON
admet-2043	200	6	non	non	ADJ
admet-2043	200	7	-	-	ADJ
admet-2043	200	8	specific	specific	ADJ
admet-2043	200	9	nature	nature	NOUN
admet-2043	200	10	,	,	PUNCT
admet-2043	200	11	amt	amt	PROPN
admet-2043	200	12	has	have	VERB
admet-2043	200	13	restrictions	restriction	NOUN
admet-2043	200	14	such	such	ADJ
admet-2043	200	15	as	as	ADP
admet-2043	200	16	a	a	DET
admet-2043	200	17	lack	lack	NOUN
admet-2043	200	18	of	of	ADP
admet-2043	200	19	selectivity	selectivity	NOUN
admet-2043	200	20	,	,	PUNCT
admet-2043	200	21	intrinsic	intrinsic	ADJ
admet-2043	200	22	toxicity	toxicity	NOUN
admet-2043	200	23	,	,	PUNCT
admet-2043	200	24	a	a	DET
admet-2043	200	25	limited	limited	ADJ
admet-2043	200	26	capacity	capacity	NOUN
admet-2043	200	27	for	for	ADP
admet-2043	200	28	transporting	transport	VERB
admet-2043	200	29	larger	large	ADJ
admet-2043	200	30	nps	nps	PROPN
admet-2043	200	31	,	,	PUNCT
admet-2043	200	32	and	and	CCONJ
admet-2043	200	33	competitive	competitive	ADJ
admet-2043	200	34	interactions	interaction	NOUN
admet-2043	200	35	with	with	ADP
admet-2043	200	36	anionic	anionic	ADJ
admet-2043	200	37	molecules	molecule	NOUN
admet-2043	200	38	or	or	CCONJ
admet-2043	200	39	cell	cell	NOUN
admet-2043	200	40	membranes	membrane	NOUN
admet-2043	200	41	,	,	PUNCT
admet-2043	200	42	which	which	PRON
admet-2043	200	43	can	can	AUX
admet-2043	200	44	restrict	restrict	VERB
admet-2043	200	45	its	its	PRON
admet-2043	200	46	usefulness	usefulness	NOUN
admet-2043	200	47	[	[	X
admet-2043	200	48	59	59	NUM
admet-2043	200	49	]	]	PUNCT
admet-2043	200	50	.	.	PUNCT
admet-2043	201	1	cell	cell	NOUN
admet-2043	201	2	-	-	PUNCT
admet-2043	201	3	penetrating	penetrate	VERB
admet-2043	201	4	peptide	peptide	NOUN
admet-2043	201	5	(	(	PUNCT
admet-2043	201	6	cpp)-related	cpp)-relate	VERB
admet-2043	201	7	transport	transport	NOUN
admet-2043	201	8	another	another	DET
admet-2043	201	9	method	method	NOUN
admet-2043	201	10	involves	involve	VERB
admet-2043	201	11	the	the	DET
admet-2043	201	12	use	use	NOUN
admet-2043	201	13	of	of	ADP
admet-2043	201	14	cell	cell	NOUN
admet-2043	201	15	-	-	PUNCT
admet-2043	201	16	penetrating	penetrate	VERB
admet-2043	201	17	peptides	peptide	NOUN
admet-2043	201	18	to	to	PART
admet-2043	201	19	improve	improve	VERB
admet-2043	201	20	cns	cns	NOUN
admet-2043	201	21	delivery	delivery	NOUN
admet-2043	201	22	[	[	X
admet-2043	201	23	60	60	NUM
admet-2043	201	24	]	]	PUNCT
admet-2043	201	25	.	.	PUNCT
admet-2043	202	1	cpps	cpps	PROPN
admet-2043	202	2	are	be	AUX
admet-2043	202	3	made	make	VERB
admet-2043	202	4	up	up	ADP
admet-2043	202	5	of	of	ADP
admet-2043	202	6	a	a	DET
admet-2043	202	7	series	series	NOUN
admet-2043	202	8	of	of	ADP
admet-2043	202	9	extremely	extremely	ADV
admet-2043	202	10	basic	basic	ADJ
admet-2043	202	11	amino	amino	ADJ
admet-2043	202	12	acids	acid	NOUN
admet-2043	202	13	that	that	PRON
admet-2043	202	14	give	give	VERB
admet-2043	202	15	the	the	DET
admet-2043	202	16	peptide	peptide	NOUN
admet-2043	202	17	a	a	DET
admet-2043	202	18	positive	positive	ADJ
admet-2043	202	19	charge	charge	NOUN
admet-2043	202	20	.	.	PUNCT
admet-2043	203	1	they	they	PRON
admet-2043	203	2	interact	interact	VERB
admet-2043	203	3	with	with	ADP
admet-2043	203	4	the	the	DET
admet-2043	203	5	cell	cell	NOUN
admet-2043	203	6	surface	surface	NOUN
admet-2043	203	7	through	through	ADP
admet-2043	203	8	a	a	DET
admet-2043	203	9	receptor	receptor	NOUN
admet-2043	203	10	-	-	PUNCT
admet-2043	203	11	independent	independent	ADJ
admet-2043	203	12	manner	manner	NOUN
admet-2043	203	13	.	.	PUNCT
admet-2043	204	1	cpps	cpps	PROPN
admet-2043	204	2	can	can	AUX
admet-2043	204	3	also	also	ADV
admet-2043	204	4	transport	transport	VERB
admet-2043	204	5	molecules	molecule	NOUN
admet-2043	204	6	linked	link	VERB
admet-2043	204	7	to	to	ADP
admet-2043	204	8	them	they	PRON
admet-2043	204	9	through	through	ADP
admet-2043	204	10	the	the	DET
admet-2043	204	11	cell	cell	NOUN
admet-2043	204	12	membrane	membrane	NOUN
admet-2043	204	13	,	,	PUNCT
admet-2043	204	14	the	the	DET
admet-2043	204	15	cytoplasm	cytoplasm	NOUN
admet-2043	204	16	,	,	PUNCT
admet-2043	204	17	and	and	CCONJ
admet-2043	204	18	the	the	DET
admet-2043	204	19	nucleus	nucleus	NOUN
admet-2043	204	20	.	.	PUNCT
admet-2043	205	1	the	the	DET
admet-2043	205	2	effect	effect	NOUN
admet-2043	205	3	is	be	AUX
admet-2043	205	4	unaffected	unaffected	ADJ
admet-2043	205	5	by	by	ADP
admet-2043	205	6	cell	cell	NOUN
admet-2043	205	7	type	type	NOUN
admet-2043	205	8	.	.	PUNCT
admet-2043	206	1	cpps	cpps	PROPN
admet-2043	206	2	were	be	AUX
admet-2043	206	3	found	find	VERB
admet-2043	206	4	in	in	ADP
admet-2043	206	5	1988	1988	NUM
admet-2043	206	6	.	.	PUNCT
admet-2043	207	1	in	in	ADP
admet-2043	207	2	hiv	hiv	PROPN
admet-2043	207	3	and	and	CCONJ
admet-2043	207	4	are	be	AUX
admet-2043	207	5	known	know	VERB
admet-2043	207	6	for	for	ADP
admet-2043	207	7	their	their	PRON
admet-2043	207	8	capacity	capacity	NOUN
admet-2043	207	9	to	to	PART
admet-2043	207	10	enhance	enhance	VERB
admet-2043	207	11	transport	transport	NOUN
admet-2043	207	12	across	across	ADP
admet-2043	207	13	cell	cell	NOUN
admet-2043	207	14	membranes	membrane	NOUN
admet-2043	207	15	[	[	X
admet-2043	207	16	61	61	NUM
admet-2043	207	17	]	]	PUNCT
admet-2043	207	18	.	.	PUNCT
admet-2043	208	1	the	the	DET
admet-2043	208	2	bbb	bbb	PROPN
admet-2043	208	3	,	,	PUNCT
admet-2043	208	4	being	be	AUX
admet-2043	208	5	a	a	DET
admet-2043	208	6	negatively	negatively	ADV
admet-2043	208	7	charged	charge	VERB
admet-2043	208	8	membrane	membrane	NOUN
admet-2043	208	9	,	,	PUNCT
admet-2043	208	10	exhibited	exhibit	VERB
admet-2043	208	11	attraction	attraction	NOUN
admet-2043	208	12	for	for	ADP
admet-2043	208	13	cpps	cpps	NOUN
admet-2043	208	14	.	.	PUNCT
admet-2043	209	1	qin	qin	PROPN
admet-2043	209	2	et	et	PROPN
admet-2043	209	3	al	al	PROPN
admet-2043	209	4	.	.	PROPN
admet-2043	209	5	demonstrated	demonstrate	VERB
admet-2043	209	6	that	that	SCONJ
admet-2043	209	7	modifying	modify	VERB
admet-2043	209	8	transactivating	transactivating	NOUN
admet-2043	209	9	-	-	PUNCT
admet-2043	209	10	transduction	transduction	NOUN
admet-2043	209	11	(	(	PUNCT
admet-2043	209	12	tat	tat	NOUN
admet-2043	209	13	)	)	PUNCT
admet-2043	209	14	onto	onto	ADP
admet-2043	209	15	liposomes	liposome	NOUN
admet-2043	209	16	(	(	PUNCT
admet-2043	209	17	tat	tat	NOUN
admet-2043	209	18	-	-	PUNCT
admet-2043	209	19	liposomes	liposome	NOUN
admet-2043	209	20	)	)	PUNCT
admet-2043	209	21	might	might	AUX
admet-2043	209	22	increase	increase	VERB
admet-2043	209	23	accumulation	accumulation	NOUN
admet-2043	209	24	in	in	ADP
admet-2043	209	25	the	the	DET
admet-2043	209	26	brain	brain	NOUN
admet-2043	209	27	by	by	ADP
admet-2043	209	28	2.54	2.54	NUM
admet-2043	209	29	-	-	NOUN
admet-2043	209	30	fold	fold	ADJ
admet-2043	209	31	over	over	ADV
admet-2043	209	32	unmodified	unmodified	ADJ
admet-2043	209	33	liposomes	liposome	NOUN
admet-2043	210	1	[	[	X
admet-2043	210	2	62	62	NUM
admet-2043	210	3	]	]	PUNCT
admet-2043	210	4	.	.	PUNCT
admet-2043	211	1	tat	tat	ADJ
admet-2043	211	2	protein	protein	NOUN
admet-2043	211	3	is	be	AUX
admet-2043	211	4	capable	capable	ADJ
admet-2043	211	5	of	of	ADP
admet-2043	211	6	migrating	migrate	VERB
admet-2043	211	7	from	from	ADP
admet-2043	211	8	quiescently	quiescently	ADV
admet-2043	211	9	infected	infect	VERB
admet-2043	211	10	cells	cell	NOUN
admet-2043	211	11	to	to	ADP
admet-2043	211	12	cells	cell	NOUN
admet-2043	211	13	that	that	PRON
admet-2043	211	14	are	be	AUX
admet-2043	211	15	uninfected	uninfected	ADJ
admet-2043	211	16	and	and	CCONJ
admet-2043	211	17	initiating	initiate	VERB
admet-2043	211	18	viral	viral	ADJ
admet-2043	211	19	replication	replication	NOUN
admet-2043	211	20	.	.	PUNCT
admet-2043	212	1	tat	tat	NOUN
admet-2043	212	2	peptide	peptide	NOUN
admet-2043	212	3	is	be	AUX
admet-2043	212	4	a	a	DET
admet-2043	212	5	short	short	ADJ
admet-2043	212	6	polypeptide	polypeptide	NOUN
admet-2043	212	7	of	of	ADP
admet-2043	212	8	86	86	NUM
admet-2043	212	9	amino	amino	NOUN
admet-2043	212	10	acid	acid	NOUN
admet-2043	212	11	residues	residue	NOUN
admet-2043	212	12	and	and	CCONJ
admet-2043	212	13	a	a	DET
admet-2043	212	14	cysteine	cysteine	ADJ
admet-2043	212	15	-	-	PUNCT
admet-2043	212	16	rich	rich	ADJ
admet-2043	212	17	region	region	NOUN
admet-2043	212	18	.	.	PUNCT
admet-2043	213	1	tat	tat	PROPN
admet-2043	213	2	peptide	peptide	NOUN
admet-2043	213	3	has	have	AUX
admet-2043	213	4	been	be	AUX
admet-2043	213	5	shown	show	VERB
admet-2043	213	6	to	to	PART
admet-2043	213	7	permeate	permeate	VERB
admet-2043	213	8	the	the	DET
admet-2043	213	9	cell	cell	NOUN
admet-2043	213	10	membrane	membrane	NOUN
admet-2043	213	11	in	in	ADP
admet-2043	213	12	a	a	DET
admet-2043	213	13	receptor	receptor	NOUN
admet-2043	213	14	and	and	CCONJ
admet-2043	213	15	transporter	transporter	NOUN
admet-2043	213	16	-	-	PUNCT
admet-2043	213	17	independent	independent	ADJ
admet-2043	213	18	manner	manner	NOUN
admet-2043	213	19	.	.	PUNCT
admet-2043	213	20	endocytosis	endocytosis	NOUN
admet-2043	213	21	and	and	CCONJ
admet-2043	213	22	pinocytosis	pinocytosis	NOUN
admet-2043	213	23	are	be	AUX
admet-2043	213	24	the	the	DET
admet-2043	213	25	basic	basic	ADJ
admet-2043	213	26	processes	process	NOUN
admet-2043	213	27	postulated	postulate	VERB
admet-2043	213	28	to	to	PART
admet-2043	213	29	explain	explain	VERB
admet-2043	213	30	tat	tat	ADJ
admet-2043	213	31	peptide	peptide	ADJ
admet-2043	213	32	cellular	cellular	ADJ
admet-2043	213	33	absorption	absorption	NOUN
admet-2043	213	34	.	.	PUNCT
admet-2043	214	1	tat	tat	PROPN
admet-2043	214	2	conjugation	conjugation	NOUN
admet-2043	214	3	was	be	AUX
admet-2043	214	4	used	use	VERB
admet-2043	214	5	to	to	PART
admet-2043	214	6	help	help	VERB
admet-2043	214	7	transfer	transfer	VERB
admet-2043	214	8	biomacromolecules	biomacromolecule	NOUN
admet-2043	214	9	over	over	ADP
admet-2043	214	10	the	the	DET
admet-2043	214	11	bbb	bbb	PROPN
admet-2043	214	12	.	.	PUNCT
admet-2043	215	1	another	another	DET
admet-2043	215	2	investigation	investigation	NOUN
admet-2043	215	3	found	find	VERB
admet-2043	215	4	that	that	SCONJ
admet-2043	215	5	tat	tat	NOUN
admet-2043	215	6	-	-	PUNCT
admet-2043	215	7	conjugated	conjugate	VERB
admet-2043	215	8	chitosan	chitosan	PROPN
admet-2043	215	9	nps	nps	PROPN
admet-2043	215	10	improved	improve	VERB
admet-2043	215	11	the	the	DET
admet-2043	215	12	transport	transport	NOUN
admet-2043	215	13	of	of	ADP
admet-2043	215	14	genes	gene	NOUN
admet-2043	215	15	to	to	ADP
admet-2043	215	16	the	the	DET
admet-2043	215	17	brain	brain	NOUN
admet-2043	215	18	[	[	X
admet-2043	215	19	63	63	NUM
admet-2043	215	20	]	]	PUNCT
admet-2043	215	21	.	.	PUNCT
admet-2043	216	1	gd3	gd3	PROPN
admet-2043	216	2	and	and	CCONJ
admet-2043	216	3	doxorubicin	doxorubicin	PROPN
admet-2043	216	4	may	may	AUX
admet-2043	216	5	be	be	AUX
admet-2043	216	6	delivered	deliver	VERB
admet-2043	216	7	to	to	ADP
admet-2043	216	8	gliomas	glioma	NOUN
admet-2043	216	9	more	more	ADV
admet-2043	216	10	effectively	effectively	ADV
admet-2043	216	11	by	by	ADP
admet-2043	216	12	tat	tat	ADJ
admet-2043	216	13	-	-	PUNCT
admet-2043	216	14	modified	modify	VERB
admet-2043	216	15	gold	gold	NOUN
admet-2043	216	16	nanoparticles	nanoparticle	NOUN
admet-2043	216	17	than	than	ADP
admet-2043	216	18	by	by	ADP
admet-2043	216	19	gd3	gd3	PROPN
admet-2043	216	20	and	and	CCONJ
admet-2043	216	21	free	free	ADJ
admet-2043	216	22	doxorubicin	doxorubicin	PROPN
admet-2043	217	1	[	[	X
admet-2043	217	2	64	64	NUM
admet-2043	217	3	]	]	PUNCT
admet-2043	217	4	.	.	PUNCT
admet-2043	218	1	additional	additional	ADJ
admet-2043	218	2	cpps	cpp	NOUN
admet-2043	218	3	,	,	PUNCT
admet-2043	218	4	including	include	VERB
admet-2043	218	5	octa	octa	PROPN
admet-2043	218	6	arginine	arginine	NOUN
admet-2043	218	7	,	,	PUNCT
admet-2043	218	8	have	have	AUX
admet-2043	218	9	been	be	AUX
admet-2043	218	10	proven	prove	VERB
admet-2043	218	11	to	to	PART
admet-2043	218	12	have	have	VERB
admet-2043	218	13	the	the	DET
admet-2043	218	14	ability	ability	NOUN
admet-2043	218	15	to	to	PART
admet-2043	218	16	target	target	VERB
admet-2043	218	17	the	the	DET
admet-2043	218	18	bbb	bbb	NOUN
admet-2043	218	19	,	,	PUNCT
admet-2043	218	20	and	and	CCONJ
admet-2043	218	21	it	it	PRON
admet-2043	218	22	has	have	AUX
admet-2043	218	23	been	be	AUX
admet-2043	218	24	shown	show	VERB
admet-2043	218	25	that	that	SCONJ
admet-2043	218	26	the	the	DET
admet-2043	218	27	effectiveness	effectiveness	NOUN
admet-2043	218	28	of	of	ADP
admet-2043	218	29	brain	brain	NOUN
admet-2043	218	30	targeting	target	VERB
admet-2043	218	31	is	be	AUX
admet-2043	218	32	directly	directly	ADV
admet-2043	218	33	correlated	correlate	VERB
admet-2043	218	34	with	with	ADP
admet-2043	218	35	cpp	cpp	PROPN
admet-2043	218	36	positive	positive	ADJ
admet-2043	218	37	charge	charge	NOUN
admet-2043	219	1	[	[	X
admet-2043	219	2	65	65	NUM
admet-2043	219	3	]	]	PUNCT
admet-2043	219	4	.	.	PUNCT
admet-2043	220	1	the	the	DET
admet-2043	220	2	chance	chance	NOUN
admet-2043	220	3	of	of	ADP
admet-2043	220	4	a	a	DET
admet-2043	220	5	drug	drug	NOUN
admet-2043	220	6	-	-	PUNCT
admet-2043	220	7	related	relate	VERB
admet-2043	220	8	adverse	adverse	ADJ
admet-2043	220	9	effect	effect	NOUN
admet-2043	220	10	increased	increase	VERB
admet-2043	220	11	as	as	ADP
admet-2043	220	12	a	a	DET
admet-2043	220	13	result	result	NOUN
admet-2043	220	14	of	of	ADP
admet-2043	220	15	cpp	cpp	NOUN
admet-2043	220	16	change	change	NOUN
admet-2043	220	17	since	since	SCONJ
admet-2043	220	18	it	it	PRON
admet-2043	220	19	enhanced	enhance	VERB
admet-2043	220	20	bbb	bbb	PROPN
admet-2043	220	21	penetration	penetration	NOUN
admet-2043	220	22	and	and	CCONJ
admet-2043	220	23	accumulation	accumulation	NOUN
admet-2043	220	24	in	in	ADP
admet-2043	220	25	other	other	ADJ
admet-2043	220	26	organs	organ	NOUN
admet-2043	220	27	,	,	PUNCT
admet-2043	220	28	including	include	VERB
admet-2043	220	29	the	the	DET
admet-2043	220	30	liver	liver	NOUN
admet-2043	220	31	and	and	CCONJ
admet-2043	220	32	spleen	spleen	NOUN
admet-2043	220	33	[	[	X
admet-2043	220	34	66	66	NUM
admet-2043	220	35	]	]	PUNCT
admet-2043	220	36	.	.	PUNCT
admet-2043	221	1	sharma	sharma	PROPN
admet-2043	221	2	et	et	PROPN
admet-2043	221	3	al	al	PROPN
admet-2043	221	4	.	.	PROPN
admet-2043	221	5	developed	develop	VERB
admet-2043	221	6	the	the	DET
admet-2043	221	7	bi	bi	ADJ
admet-2043	221	8	-	-	ADJ
admet-2043	221	9	ligand	ligand	ADJ
admet-2043	221	10	tf	tf	NOUN
admet-2043	221	11	-	-	PUNCT
admet-2043	221	12	pr	pr	NOUN
admet-2043	221	13	by	by	ADP
admet-2043	221	14	conjugating	conjugate	VERB
admet-2043	221	15	tf	tf	PROPN
admet-2043	221	16	with	with	ADP
admet-2043	221	17	poly	poly	ADJ
admet-2043	221	18	-	-	PUNCT
admet-2043	221	19	l	l	NOUN
admet-2043	221	20	-	-	NOUN
admet-2043	221	21	arginine	arginine	NOUN
admet-2043	221	22	.	.	PUNCT
admet-2043	222	1	tf	tf	ADJ
admet-2043	222	2	-	-	PUNCT
admet-2043	222	3	pr	pr	NOUN
admet-2043	222	4	-	-	PUNCT
admet-2043	222	5	liposomes	liposome	NOUN
admet-2043	222	6	had	have	VERB
admet-2043	222	7	much	much	ADV
admet-2043	222	8	higher	high	ADJ
admet-2043	222	9	cellular	cellular	ADJ
admet-2043	222	10	uptake	uptake	NOUN
admet-2043	222	11	in	in	ADP
admet-2043	222	12	vitro	vitro	ADJ
admet-2043	222	13	than	than	ADP
admet-2043	222	14	tf	tf	NOUN
admet-2043	222	15	-	-	PUNCT
admet-2043	222	16	liposomes	liposome	NOUN
admet-2043	222	17	and	and	CCONJ
admet-2043	222	18	pr	pr	NOUN
admet-2043	222	19	-	-	PUNCT
admet-2043	222	20	liposomes	liposome	NOUN
admet-2043	222	21	.	.	PUNCT
admet-2043	223	1	after	after	ADP
admet-2043	223	2	8	8	NUM
admet-2043	223	3	hours	hour	NOUN
admet-2043	223	4	of	of	ADP
admet-2043	223	5	incubation	incubation	NOUN
admet-2043	223	6	,	,	PUNCT
admet-2043	223	7	the	the	DET
admet-2043	223	8	transfer	transfer	NOUN
admet-2043	223	9	percentage	percentage	NOUN
admet-2043	223	10	of	of	ADP
admet-2043	223	11	tf	tf	PROPN
admet-2043	223	12	-	-	PUNCT
admet-2043	223	13	pr	pr	NOUN
admet-2043	223	14	-	-	PUNCT
admet-2043	223	15	liposomes	liposome	NOUN
admet-2043	223	16	was	be	AUX
admet-2043	223	17	19	19	NUM
admet-2043	223	18	%	%	NOUN
admet-2043	223	19	,	,	PUNCT
admet-2043	223	20	significantly	significantly	ADV
admet-2043	223	21	greater	great	ADJ
admet-2043	223	22	than	than	ADP
admet-2043	223	23	that	that	PRON
admet-2043	223	24	of	of	ADP
admet-2043	223	25	tf	tf	PROPN
admet-2043	223	26	-	-	PUNCT
admet-2043	223	27	liposomes	liposome	NOUN
admet-2043	223	28	(	(	PUNCT
admet-2043	223	29	13	13	NUM
admet-2043	223	30	%	%	NOUN
admet-2043	223	31	)	)	PUNCT
admet-2043	223	32	and	and	CCONJ
admet-2043	223	33	prliposomes	prliposome	NOUN
admet-2043	223	34	(	(	PUNCT
admet-2043	223	35	10	10	NUM
admet-2043	223	36	%	%	NOUN
admet-2043	223	37	)	)	PUNCT
admet-2043	224	1	[	[	X
admet-2043	224	2	67	67	NUM
admet-2043	224	3	]	]	PUNCT
admet-2043	224	4	.	.	PUNCT
admet-2043	225	1	tf	tf	ADJ
admet-2043	225	2	-	-	PUNCT
admet-2043	225	3	pr	pr	NOUN
admet-2043	225	4	-	-	PUNCT
admet-2043	225	5	liposomes	liposome	NOUN
admet-2043	225	6	had	have	VERB
admet-2043	225	7	about	about	ADV
admet-2043	225	8	a	a	DET
admet-2043	225	9	2	2	NUM
admet-2043	225	10	-	-	ADJ
admet-2043	225	11	fold	fold	ADJ
admet-2043	225	12	greater	great	ADJ
admet-2043	225	13	brain	brain	NOUN
admet-2043	225	14	targeting	targeting	NOUN
admet-2043	225	15	impact	impact	NOUN
admet-2043	225	16	than	than	ADP
admet-2043	225	17	tf	tf	NOUN
admet-2043	225	18	-	-	PUNCT
admet-2043	225	19	liposomes	liposome	NOUN
admet-2043	225	20	in	in	ADP
admet-2043	225	21	vivo	vivo	NOUN
admet-2043	225	22	.	.	PUNCT
admet-2043	226	1	as	as	ADP
admet-2043	226	2	a	a	DET
admet-2043	226	3	consequence	consequence	NOUN
admet-2043	226	4	,	,	PUNCT
admet-2043	226	5	gene	gene	NOUN
admet-2043	226	6	expression	expression	NOUN
admet-2043	226	7	was	be	AUX
admet-2043	226	8	1.66	1.66	NUM
admet-2043	226	9	-	-	NUM
admet-2043	226	10	fold	fold	VERB
admet-2043	226	11	higher	higher	ADV
admet-2043	226	12	in	in	ADP
admet-2043	226	13	the	the	DET
admet-2043	226	14	brains	brain	NOUN
admet-2043	226	15	of	of	ADP
admet-2043	226	16	mice	mouse	NOUN
admet-2043	226	17	treated	treat	VERB
admet-2043	226	18	with	with	ADP
admet-2043	226	19	gene	gene	NOUN
admet-2043	226	20	-	-	PUNCT
admet-2043	226	21	loaded	load	VERB
admet-2043	226	22	admet	admet	NOUN
admet-2043	226	23	&	&	CCONJ
admet-2043	226	24	dmpk	dmpk	PROPN
admet-2043	226	25	12(1	12(1	PROPN
admet-2043	226	26	)	)	PUNCT
admet-2043	226	27	(	(	PUNCT
admet-2043	226	28	2024	2024	NUM
admet-2043	226	29	)	)	PUNCT
admet-2043	226	30	63	63	NUM
admet-2043	226	31	-	-	SYM
admet-2043	226	32	105	105	NUM
admet-2043	226	33	nanomaterials	nanomaterial	NOUN
admet-2043	226	34	as	as	ADP
admet-2043	226	35	drug	drug	NOUN
admet-2043	226	36	delivery	delivery	NOUN
admet-2043	226	37	agents	agent	NOUN
admet-2043	226	38	for	for	ADP
admet-2043	226	39	overcoming	overcome	VERB
admet-2043	226	40	bbb	bbb	PROPN
admet-2043	226	41	doi	doi	NOUN
admet-2043	226	42	:	:	PUNCT
admet-2043	226	43	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	226	44	73	73	NUM
admet-2043	226	45	tf	tf	ADJ
admet-2043	226	46	-	-	PUNCT
admet-2043	226	47	pr	pr	NOUN
admet-2043	226	48	-	-	PUNCT
admet-2043	226	49	liposomes	liposome	NOUN
admet-2043	226	50	than	than	ADP
admet-2043	226	51	in	in	ADP
admet-2043	226	52	tf	tf	NOUN
admet-2043	226	53	-	-	PUNCT
admet-2043	226	54	liposomes	liposome	NOUN
admet-2043	226	55	[	[	X
admet-2043	226	56	68	68	NUM
admet-2043	226	57	]	]	PUNCT
admet-2043	226	58	.	.	PUNCT
admet-2043	227	1	liu	liu	PROPN
admet-2043	227	2	et	et	PROPN
admet-2043	227	3	al	al	PROPN
admet-2043	227	4	.	.	PUNCT
admet-2043	228	1	[	[	X
admet-2043	228	2	69	69	NUM
admet-2043	228	3	]	]	PUNCT
admet-2043	228	4	combined	combine	VERB
admet-2043	228	5	octa	octa	NOUN
admet-2043	228	6	-	-	PUNCT
admet-2043	228	7	arginine	arginine	NOUN
admet-2043	228	8	with	with	ADP
admet-2043	228	9	the	the	DET
admet-2043	228	10	c(rgdfk	c(rgdfk	NOUN
admet-2043	228	11	)	)	PUNCT
admet-2043	228	12	peptide	peptide	NOUN
admet-2043	228	13	to	to	PART
admet-2043	228	14	create	create	VERB
admet-2043	228	15	the	the	DET
admet-2043	228	16	bi	bi	ADJ
admet-2043	228	17	-	-	ADJ
admet-2043	228	18	ligand	ligand	ADJ
admet-2043	228	19	rrgd	rrgd	NOUN
admet-2043	228	20	.	.	PUNCT
admet-2043	229	1	after	after	ADP
admet-2043	229	2	paclitaxel	paclitaxel	PROPN
admet-2043	229	3	loading	loading	NOUN
admet-2043	229	4	,	,	PUNCT
admet-2043	229	5	animals	animal	NOUN
admet-2043	229	6	with	with	ADP
admet-2043	229	7	brain	brain	NOUN
admet-2043	229	8	tumours	tumour	NOUN
admet-2043	229	9	treated	treat	VERB
admet-2043	229	10	with	with	ADP
admet-2043	229	11	rrgd	rrgd	NOUN
admet-2043	229	12	-	-	PUNCT
admet-2043	229	13	liposomes	liposome	NOUN
admet-2043	229	14	had	have	VERB
admet-2043	229	15	median	median	ADJ
admet-2043	229	16	survival	survival	NOUN
admet-2043	229	17	times	time	NOUN
admet-2043	229	18	of	of	ADP
admet-2043	229	19	1.33	1.33	NUM
admet-2043	229	20	and	and	CCONJ
admet-2043	229	21	1.26	1.26	NUM
admet-2043	229	22	times	time	NOUN
admet-2043	229	23	longer	long	ADJ
admet-2043	229	24	than	than	ADP
admet-2043	229	25	those	those	PRON
admet-2043	229	26	of	of	ADP
admet-2043	229	27	mice	mouse	NOUN
admet-2043	229	28	treated	treat	VERB
admet-2043	229	29	with	with	ADP
admet-2043	229	30	r	r	NOUN
admet-2043	229	31	-	-	PUNCT
admet-2043	229	32	liposomes	liposome	NOUN
admet-2043	229	33	and	and	CCONJ
admet-2043	229	34	rgd	rgd	NOUN
admet-2043	229	35	liposomes	liposome	NOUN
admet-2043	229	36	,	,	PUNCT
admet-2043	229	37	respectively	respectively	ADV
admet-2043	229	38	[	[	X
admet-2043	229	39	69	69	NUM
admet-2043	229	40	]	]	PUNCT
admet-2043	229	41	.	.	PUNCT
admet-2043	230	1	cell	cell	NOUN
admet-2043	230	2	-	-	PUNCT
admet-2043	230	3	penetrating	penetrate	VERB
admet-2043	230	4	peptides	peptide	NOUN
admet-2043	230	5	(	(	PUNCT
admet-2043	230	6	cpps	cpp	NOUN
admet-2043	230	7	)	)	PUNCT
admet-2043	230	8	have	have	VERB
admet-2043	230	9	various	various	ADJ
admet-2043	230	10	benefits	benefit	NOUN
admet-2043	230	11	for	for	ADP
admet-2043	230	12	delivering	deliver	VERB
admet-2043	230	13	load	load	NOUN
admet-2043	230	14	inside	inside	ADP
admet-2043	230	15	cells	cell	NOUN
admet-2043	230	16	.	.	PUNCT
admet-2043	231	1	they	they	PRON
admet-2043	231	2	improve	improve	VERB
admet-2043	231	3	cellular	cellular	ADJ
admet-2043	231	4	uptake	uptake	NOUN
admet-2043	231	5	of	of	ADP
admet-2043	231	6	various	various	ADJ
admet-2043	231	7	cargo	cargo	NOUN
admet-2043	231	8	molecules	molecule	NOUN
admet-2043	231	9	,	,	PUNCT
admet-2043	231	10	breaking	break	VERB
admet-2043	231	11	down	down	ADP
admet-2043	231	12	cellular	cellular	ADJ
admet-2043	231	13	barriers	barrier	NOUN
admet-2043	231	14	and	and	CCONJ
admet-2043	231	15	allowing	allow	VERB
admet-2043	231	16	for	for	ADP
admet-2043	231	17	efficient	efficient	ADJ
admet-2043	231	18	internalisation	internalisation	NOUN
admet-2043	231	19	.	.	PUNCT
admet-2043	232	1	cpps	cpp	NOUN
admet-2043	232	2	have	have	VERB
admet-2043	232	3	minimal	minimal	ADJ
admet-2043	232	4	toxicity	toxicity	NOUN
admet-2043	232	5	,	,	PUNCT
admet-2043	232	6	good	good	ADJ
admet-2043	232	7	biocompatibility	biocompatibility	NOUN
admet-2043	232	8	,	,	PUNCT
admet-2043	232	9	and	and	CCONJ
admet-2043	232	10	the	the	DET
admet-2043	232	11	capacity	capacity	NOUN
admet-2043	232	12	to	to	PART
admet-2043	232	13	penetrate	penetrate	VERB
admet-2043	232	14	multiple	multiple	ADJ
admet-2043	232	15	cell	cell	NOUN
admet-2043	232	16	types	type	NOUN
admet-2043	232	17	,	,	PUNCT
admet-2043	232	18	making	make	VERB
admet-2043	232	19	them	they	PRON
admet-2043	232	20	ideal	ideal	ADJ
admet-2043	232	21	for	for	ADP
admet-2043	232	22	targeted	target	VERB
admet-2043	232	23	distribution	distribution	NOUN
admet-2043	232	24	[	[	X
admet-2043	232	25	70	70	NUM
admet-2043	232	26	]	]	PUNCT
admet-2043	232	27	.	.	PUNCT
admet-2043	233	1	contrary	contrary	ADJ
admet-2043	233	2	to	to	ADP
admet-2043	233	3	this	this	PRON
admet-2043	233	4	,	,	PUNCT
admet-2043	233	5	cpps	cpps	NOUN
admet-2043	233	6	exhibit	exhibit	VERB
admet-2043	233	7	a	a	DET
admet-2043	233	8	deficiency	deficiency	NOUN
admet-2043	233	9	in	in	ADP
admet-2043	233	10	cell	cell	NOUN
admet-2043	233	11	specificity	specificity	NOUN
admet-2043	233	12	,	,	PUNCT
admet-2043	233	13	as	as	SCONJ
admet-2043	233	14	they	they	PRON
admet-2043	233	15	heavily	heavily	ADV
admet-2043	233	16	rely	rely	VERB
admet-2043	233	17	on	on	ADP
admet-2043	233	18	charge	charge	NOUN
admet-2043	233	19	interactions	interaction	NOUN
admet-2043	233	20	.	.	PUNCT
admet-2043	234	1	additionally	additionally	ADV
admet-2043	234	2	,	,	PUNCT
admet-2043	234	3	cpps	cpp	NOUN
admet-2043	234	4	may	may	AUX
admet-2043	234	5	face	face	VERB
admet-2043	234	6	challenges	challenge	NOUN
admet-2043	234	7	when	when	SCONJ
admet-2043	234	8	it	it	PRON
admet-2043	234	9	comes	come	VERB
admet-2043	234	10	to	to	ADP
admet-2043	234	11	traversing	traverse	VERB
admet-2043	234	12	intracellular	intracellular	ADJ
admet-2043	234	13	barriers	barrier	NOUN
admet-2043	234	14	.	.	PUNCT
admet-2043	235	1	the	the	DET
admet-2043	235	2	transport	transport	NOUN
admet-2043	235	3	facilitated	facilitate	VERB
admet-2043	235	4	by	by	ADP
admet-2043	235	5	cell	cell	NOUN
admet-2043	235	6	-	-	PUNCT
admet-2043	235	7	penetrating	penetrate	VERB
admet-2043	235	8	peptides	peptide	NOUN
admet-2043	235	9	(	(	PUNCT
admet-2043	235	10	cpps	cpps	PROPN
admet-2043	235	11	)	)	PUNCT
admet-2043	235	12	exhibits	exhibit	VERB
admet-2043	235	13	a	a	DET
admet-2043	235	14	size	size	NOUN
admet-2043	235	15	-	-	PUNCT
admet-2043	235	16	dependent	dependent	ADJ
admet-2043	235	17	characteristic	characteristic	NOUN
admet-2043	235	18	,	,	PUNCT
admet-2043	235	19	wherein	wherein	SCONJ
admet-2043	235	20	larger	large	ADJ
admet-2043	235	21	cargo	cargo	NOUN
admet-2043	235	22	molecules	molecule	NOUN
admet-2043	235	23	demonstrate	demonstrate	VERB
admet-2043	235	24	reduced	reduce	VERB
admet-2043	235	25	efficiency	efficiency	NOUN
admet-2043	235	26	.	.	PUNCT
admet-2043	236	1	additionally	additionally	ADV
admet-2043	236	2	,	,	PUNCT
admet-2043	236	3	it	it	PRON
admet-2043	236	4	is	be	AUX
admet-2043	236	5	crucial	crucial	ADJ
admet-2043	236	6	to	to	PART
admet-2043	236	7	address	address	VERB
admet-2043	236	8	the	the	DET
admet-2043	236	9	issues	issue	NOUN
admet-2043	236	10	of	of	ADP
admet-2043	236	11	immunegenicity	immunegenicity	NOUN
admet-2043	236	12	and	and	CCONJ
admet-2043	236	13	design	design	NOUN
admet-2043	236	14	complexity	complexity	NOUN
admet-2043	236	15	associated	associate	VERB
admet-2043	236	16	with	with	ADP
admet-2043	236	17	cpp	cpp	NOUN
admet-2043	236	18	-	-	PUNCT
admet-2043	236	19	based	base	VERB
admet-2043	236	20	delivery	delivery	NOUN
admet-2043	236	21	systems	system	NOUN
admet-2043	236	22	[	[	X
admet-2043	236	23	71	71	NUM
admet-2043	236	24	]	]	PUNCT
admet-2043	236	25	.	.	PUNCT
admet-2043	237	1	temporarily	temporarily	ADV
admet-2043	237	2	open	open	VERB
admet-2043	237	3	the	the	DET
admet-2043	237	4	bbb	bbb	NOUN
admet-2043	237	5	several	several	ADJ
admet-2043	237	6	physical	physical	ADJ
admet-2043	237	7	and	and	CCONJ
admet-2043	237	8	pharmacological	pharmacological	ADJ
admet-2043	237	9	approaches	approach	NOUN
admet-2043	237	10	could	could	AUX
admet-2043	237	11	be	be	AUX
admet-2043	237	12	used	use	VERB
admet-2043	237	13	to	to	PART
admet-2043	237	14	briefly	briefly	VERB
admet-2043	237	15	access	access	VERB
admet-2043	237	16	the	the	DET
admet-2043	237	17	bbb	bbb	PROPN
admet-2043	237	18	.	.	PUNCT
admet-2043	238	1	because	because	SCONJ
admet-2043	238	2	the	the	DET
admet-2043	238	3	bbb	bbb	PROPN
admet-2043	238	4	is	be	AUX
admet-2043	238	5	the	the	DET
admet-2043	238	6	primary	primary	ADJ
admet-2043	238	7	barrier	barrier	NOUN
admet-2043	238	8	preventing	prevent	VERB
admet-2043	238	9	compounds	compound	NOUN
admet-2043	238	10	or	or	CCONJ
admet-2043	238	11	nps	nps	PROPN
admet-2043	238	12	from	from	ADP
admet-2043	238	13	entering	enter	VERB
admet-2043	238	14	the	the	DET
admet-2043	238	15	brain	brain	NOUN
admet-2043	238	16	directly	directly	ADV
admet-2043	238	17	,	,	PUNCT
admet-2043	238	18	temporarily	temporarily	ADV
admet-2043	238	19	opening	open	VERB
admet-2043	238	20	the	the	DET
admet-2043	238	21	bbb	bbb	NOUN
admet-2043	238	22	to	to	PART
admet-2043	238	23	enlarge	enlarge	VERB
admet-2043	238	24	the	the	DET
admet-2043	238	25	pore	pore	ADJ
admet-2043	238	26	size	size	NOUN
admet-2043	238	27	might	might	AUX
admet-2043	238	28	allow	allow	VERB
admet-2043	238	29	substances	substance	NOUN
admet-2043	238	30	or	or	CCONJ
admet-2043	238	31	nps	nps	PROPN
admet-2043	238	32	to	to	PART
admet-2043	238	33	enter	enter	VERB
admet-2043	238	34	the	the	DET
admet-2043	238	35	brain	brain	NOUN
admet-2043	238	36	directly	directly	ADV
admet-2043	238	37	.	.	PUNCT
admet-2043	239	1	chemicals	chemical	NOUN
admet-2043	239	2	that	that	PRON
admet-2043	239	3	enhance	enhance	VERB
admet-2043	239	4	bbb	bbb	PROPN
admet-2043	239	5	permeability	permeability	NOUN
admet-2043	239	6	the	the	DET
admet-2043	239	7	permeability	permeability	NOUN
admet-2043	239	8	of	of	ADP
admet-2043	239	9	several	several	ADJ
admet-2043	239	10	membranes	membrane	NOUN
admet-2043	239	11	,	,	PUNCT
admet-2043	239	12	including	include	VERB
admet-2043	239	13	the	the	DET
admet-2043	239	14	mucosa	mucosa	NOUN
admet-2043	239	15	,	,	PUNCT
admet-2043	239	16	skin	skin	NOUN
admet-2043	239	17	,	,	PUNCT
admet-2043	239	18	and	and	CCONJ
admet-2043	239	19	bbb	bbb	NOUN
admet-2043	239	20	,	,	PUNCT
admet-2043	239	21	can	can	AUX
admet-2043	239	22	be	be	AUX
admet-2043	239	23	increased	increase	VERB
admet-2043	239	24	by	by	ADP
admet-2043	239	25	borneol	borneol	NOUN
admet-2043	239	26	,	,	PUNCT
admet-2043	239	27	a	a	DET
admet-2043	239	28	messenger	messenger	NOUN
admet-2043	239	29	medication	medication	NOUN
admet-2043	239	30	often	often	ADV
admet-2043	239	31	used	use	VERB
admet-2043	239	32	in	in	ADP
admet-2043	239	33	traditional	traditional	ADJ
admet-2043	239	34	chinese	chinese	ADJ
admet-2043	239	35	medicine	medicine	NOUN
admet-2043	239	36	[	[	X
admet-2043	239	37	72	72	NUM
admet-2043	239	38	]	]	PUNCT
admet-2043	239	39	.	.	PUNCT
admet-2043	240	1	similarly	similarly	ADV
admet-2043	240	2	,	,	PUNCT
admet-2043	240	3	alkylglycerols	alkylglycerol	NOUN
admet-2043	240	4	may	may	AUX
admet-2043	240	5	open	open	VERB
admet-2043	240	6	the	the	DET
admet-2043	240	7	bbb	bbb	NOUN
admet-2043	240	8	and	and	CCONJ
admet-2043	240	9	promote	promote	VERB
admet-2043	240	10	medication	medication	NOUN
admet-2043	240	11	transport	transport	NOUN
admet-2043	240	12	to	to	ADP
admet-2043	240	13	the	the	DET
admet-2043	240	14	brain	brain	NOUN
admet-2043	240	15	.	.	PUNCT
admet-2043	241	1	modified	modify	VERB
admet-2043	241	2	alkylglycerol	alkylglycerol	NOUN
admet-2043	241	3	was	be	AUX
admet-2043	241	4	grafted	graft	VERB
admet-2043	241	5	onto	onto	ADP
admet-2043	241	6	dextran	dextran	NOUN
admet-2043	241	7	-	-	PUNCT
admet-2043	241	8	graft	graft	NOUN
admet-2043	241	9	-	-	PUNCT
admet-2043	241	10	poly(lactic	poly(lactic	ADJ
admet-2043	241	11	acid	acid	NOUN
admet-2043	241	12	)	)	PUNCT
admet-2043	241	13	nps	nps	PROPN
admet-2043	241	14	for	for	ADP
admet-2043	241	15	delivery	delivery	NOUN
admet-2043	241	16	with	with	ADP
admet-2043	241	17	a	a	DET
admet-2043	241	18	focus	focus	NOUN
admet-2043	241	19	on	on	ADP
admet-2043	241	20	the	the	DET
admet-2043	241	21	brain	brain	NOUN
admet-2043	241	22	(	(	PUNCT
admet-2043	241	23	pladex	pladex	NOUN
admet-2043	241	24	-	-	PUNCT
admet-2043	241	25	ox4	ox4	NOUN
admet-2043	241	26	)	)	PUNCT
admet-2043	241	27	.	.	PUNCT
admet-2043	242	1	compared	compare	VERB
admet-2043	242	2	to	to	ADP
admet-2043	242	3	free	free	ADJ
admet-2043	242	4	dextran	dextran	NOUN
admet-2043	242	5	and	and	CCONJ
admet-2043	242	6	unmodified	unmodified	ADJ
admet-2043	242	7	nps	nps	PROPN
admet-2043	242	8	,	,	PUNCT
admet-2043	242	9	pla	pla	NOUN
admet-2043	242	10	-	-	PUNCT
admet-2043	242	11	dex	dex	NOUN
admet-2043	242	12	-	-	PUNCT
admet-2043	242	13	ox4	ox4	NOUN
admet-2043	242	14	penetrated	penetrate	VERB
admet-2043	242	15	the	the	DET
admet-2043	242	16	bend.3	bend.3	PROPN
admet-2043	242	17	monolayer	monolayer	NOUN
admet-2043	242	18	more	more	ADV
admet-2043	242	19	deeply	deeply	ADV
admet-2043	242	20	.	.	PUNCT
admet-2043	243	1	sadly	sadly	ADV
admet-2043	243	2	,	,	PUNCT
admet-2043	243	3	no	no	DET
admet-2043	243	4	statistically	statistically	ADV
admet-2043	243	5	significant	significant	ADJ
admet-2043	243	6	difference	difference	NOUN
admet-2043	243	7	was	be	AUX
admet-2043	243	8	found	find	VERB
admet-2043	243	9	,	,	PUNCT
admet-2043	243	10	suggesting	suggest	VERB
admet-2043	243	11	that	that	SCONJ
admet-2043	243	12	the	the	DET
admet-2043	243	13	alkylglycerol	alkylglycerol	NOUN
admet-2043	243	14	modification	modification	NOUN
admet-2043	243	15	's	's	PART
admet-2043	243	16	effectiveness	effectiveness	NOUN
admet-2043	243	17	was	be	AUX
admet-2043	243	18	satisfactory	satisfactory	ADJ
admet-2043	243	19	[	[	X
admet-2043	243	20	73	73	NUM
admet-2043	243	21	]	]	PUNCT
admet-2043	243	22	.	.	PUNCT
admet-2043	244	1	the	the	DET
admet-2043	244	2	myriad	myriad	ADJ
admet-2043	244	3	advantages	advantage	NOUN
admet-2043	244	4	associated	associate	VERB
admet-2043	244	5	with	with	ADP
admet-2043	244	6	chemical	chemical	ADJ
admet-2043	244	7	agents	agent	NOUN
admet-2043	244	8	that	that	PRON
admet-2043	244	9	enhance	enhance	VERB
admet-2043	244	10	bbb	bbb	PROPN
admet-2043	244	11	permeability	permeability	NOUN
admet-2043	244	12	to	to	PART
admet-2043	244	13	facilitate	facilitate	VERB
admet-2043	244	14	medication	medication	NOUN
admet-2043	244	15	delivery	delivery	NOUN
admet-2043	244	16	to	to	ADP
admet-2043	244	17	the	the	DET
admet-2043	244	18	brain	brain	NOUN
admet-2043	244	19	are	be	AUX
admet-2043	244	20	manifold	manifold	ADJ
admet-2043	244	21	.	.	PUNCT
admet-2043	245	1	the	the	DET
admet-2043	245	2	compounds	compound	NOUN
admet-2043	245	3	possess	possess	VERB
admet-2043	245	4	the	the	DET
admet-2043	245	5	potential	potential	NOUN
admet-2043	245	6	to	to	PART
admet-2043	245	7	be	be	AUX
admet-2043	245	8	strategically	strategically	ADV
admet-2043	245	9	engineered	engineer	VERB
admet-2043	245	10	in	in	ADP
admet-2043	245	11	order	order	NOUN
admet-2043	245	12	to	to	PART
admet-2043	245	13	selectively	selectively	ADV
admet-2043	245	14	interact	interact	VERB
admet-2043	245	15	with	with	ADP
admet-2043	245	16	a	a	DET
admet-2043	245	17	particular	particular	ADJ
admet-2043	245	18	subset	subset	NOUN
admet-2043	245	19	of	of	ADP
admet-2043	245	20	cerebral	cerebral	ADJ
admet-2043	245	21	cells	cell	NOUN
admet-2043	245	22	or	or	CCONJ
admet-2043	245	23	regions	region	NOUN
admet-2043	245	24	,	,	PUNCT
admet-2043	245	25	thereby	thereby	ADV
admet-2043	245	26	facilitating	facilitate	VERB
admet-2043	245	27	localised	localise	VERB
admet-2043	245	28	therapeutic	therapeutic	ADJ
admet-2043	245	29	efficacy	efficacy	NOUN
admet-2043	245	30	while	while	SCONJ
admet-2043	245	31	minimising	minimise	VERB
admet-2043	245	32	the	the	DET
admet-2043	245	33	occurrence	occurrence	NOUN
admet-2043	245	34	of	of	ADP
admet-2043	245	35	undesirable	undesirable	ADJ
admet-2043	245	36	secondary	secondary	ADJ
admet-2043	245	37	effects	effect	NOUN
admet-2043	245	38	.	.	PUNCT
admet-2043	246	1	the	the	DET
admet-2043	246	2	utilisation	utilisation	NOUN
admet-2043	246	3	of	of	ADP
admet-2043	246	4	combination	combination	NOUN
admet-2043	246	5	treatment	treatment	NOUN
admet-2043	246	6	,	,	PUNCT
admet-2043	246	7	wherein	wherein	SCONJ
admet-2043	246	8	chemical	chemical	NOUN
admet-2043	246	9	agents	agent	NOUN
admet-2043	246	10	are	be	AUX
admet-2043	246	11	concomitantly	concomitantly	ADV
admet-2043	246	12	employed	employ	VERB
admet-2043	246	13	with	with	ADP
admet-2043	246	14	alternative	alternative	ADJ
admet-2043	246	15	methodologies	methodology	NOUN
admet-2043	246	16	,	,	PUNCT
admet-2043	246	17	has	have	AUX
admet-2043	246	18	been	be	AUX
admet-2043	246	19	observed	observe	VERB
admet-2043	246	20	to	to	PART
admet-2043	246	21	elicit	elicit	VERB
admet-2043	246	22	a	a	DET
admet-2043	246	23	heightened	heightened	ADJ
admet-2043	246	24	permeability	permeability	NOUN
admet-2043	246	25	of	of	ADP
admet-2043	246	26	the	the	DET
admet-2043	246	27	bbb	bbb	NOUN
admet-2043	246	28	and	and	CCONJ
admet-2043	246	29	subsequently	subsequently	ADV
admet-2043	246	30	enhance	enhance	VERB
admet-2043	246	31	the	the	DET
admet-2043	246	32	therapeutic	therapeutic	ADJ
admet-2043	246	33	efficacy	efficacy	NOUN
admet-2043	246	34	of	of	ADP
admet-2043	246	35	the	the	DET
admet-2043	246	36	treatment	treatment	NOUN
admet-2043	246	37	regimen	regiman	NOUN
admet-2043	247	1	[	[	X
admet-2043	247	2	74	74	NUM
admet-2043	247	3	]	]	PUNCT
admet-2043	247	4	.	.	PUNCT
admet-2043	248	1	however	however	ADV
admet-2043	248	2	,	,	PUNCT
admet-2043	248	3	it	it	PRON
admet-2043	248	4	is	be	AUX
admet-2043	248	5	imperative	imperative	ADJ
admet-2043	248	6	to	to	PART
admet-2043	248	7	thoroughly	thoroughly	ADV
admet-2043	248	8	evaluate	evaluate	VERB
admet-2043	248	9	certain	certain	ADJ
admet-2043	248	10	chemicals	chemical	NOUN
admet-2043	248	11	'	'	PART
admet-2043	248	12	potential	potential	ADJ
admet-2043	248	13	toxicity	toxicity	NOUN
admet-2043	248	14	and	and	CCONJ
admet-2043	248	15	non	non	ADJ
admet-2043	248	16	-	-	ADJ
admet-2043	248	17	specific	specific	ADJ
admet-2043	248	18	effects	effect	NOUN
admet-2043	248	19	due	due	ADP
admet-2043	248	20	to	to	ADP
admet-2043	248	21	their	their	PRON
admet-2043	248	22	inherent	inherent	ADJ
admet-2043	248	23	toxicity	toxicity	NOUN
admet-2043	248	24	and	and	CCONJ
admet-2043	248	25	lack	lack	NOUN
admet-2043	248	26	of	of	ADP
admet-2043	248	27	selectivity	selectivity	NOUN
admet-2043	248	28	.	.	PUNCT
admet-2043	249	1	due	due	ADP
admet-2043	249	2	to	to	ADP
admet-2043	249	3	the	the	DET
admet-2043	249	4	transient	transient	ADJ
admet-2043	249	5	nature	nature	NOUN
admet-2043	249	6	of	of	ADP
admet-2043	249	7	enhanced	enhanced	ADJ
admet-2043	249	8	permeability	permeability	NOUN
admet-2043	249	9	,	,	PUNCT
admet-2043	249	10	it	it	PRON
admet-2043	249	11	may	may	AUX
admet-2043	249	12	be	be	AUX
admet-2043	249	13	imperative	imperative	ADJ
admet-2043	249	14	to	to	PART
admet-2043	249	15	administer	administer	VERB
admet-2043	249	16	multiple	multiple	ADJ
admet-2043	249	17	doses	dose	NOUN
admet-2043	249	18	or	or	CCONJ
admet-2043	249	19	employ	employ	VERB
admet-2043	249	20	sustained	sustain	VERB
admet-2043	249	21	-	-	PUNCT
admet-2043	249	22	release	release	NOUN
admet-2043	249	23	formulations	formulation	NOUN
admet-2043	249	24	to	to	PART
admet-2043	249	25	achieve	achieve	VERB
admet-2043	249	26	long	long	ADJ
admet-2043	249	27	-	-	PUNCT
admet-2043	249	28	term	term	NOUN
admet-2043	249	29	benefits	benefit	NOUN
admet-2043	249	30	.	.	PUNCT
admet-2043	250	1	the	the	DET
admet-2043	250	2	clinical	clinical	ADJ
admet-2043	250	3	translation	translation	NOUN
admet-2043	250	4	of	of	ADP
admet-2043	250	5	these	these	DET
admet-2043	250	6	pharmaceutical	pharmaceutical	ADJ
admet-2043	250	7	compounds	compound	NOUN
admet-2043	250	8	presents	present	VERB
admet-2043	250	9	considerable	considerable	ADJ
admet-2043	250	10	challenges	challenge	NOUN
admet-2043	250	11	,	,	PUNCT
admet-2043	250	12	necessitating	necessitate	VERB
admet-2043	250	13	further	further	ADJ
admet-2043	250	14	investigation	investigation	NOUN
admet-2043	250	15	and	and	CCONJ
admet-2043	250	16	refinement	refinement	NOUN
admet-2043	250	17	to	to	PART
admet-2043	250	18	address	address	VERB
admet-2043	250	19	regulatory	regulatory	ADJ
admet-2043	250	20	and	and	CCONJ
admet-2043	250	21	safety	safety	NOUN
admet-2043	250	22	considerations	consideration	NOUN
admet-2043	250	23	[	[	X
admet-2043	250	24	75	75	NUM
admet-2043	250	25	]	]	PUNCT
admet-2043	250	26	.	.	PUNCT
admet-2043	251	1	receptor	receptor	NOUN
admet-2043	251	2	-	-	PUNCT
admet-2043	251	3	involved	involve	VERB
admet-2043	251	4	changing	change	VERB
admet-2043	251	5	of	of	ADP
admet-2043	251	6	tight	tight	ADJ
admet-2043	251	7	junctions	junction	NOUN
admet-2043	251	8	modifying	modify	VERB
admet-2043	251	9	the	the	DET
admet-2043	251	10	tightness	tightness	NOUN
admet-2043	251	11	of	of	ADP
admet-2043	251	12	tight	tight	ADJ
admet-2043	251	13	junctions	junction	NOUN
admet-2043	251	14	is	be	AUX
admet-2043	251	15	a	a	DET
admet-2043	251	16	possible	possible	ADJ
admet-2043	251	17	method	method	NOUN
admet-2043	251	18	for	for	ADP
admet-2043	251	19	increasing	increase	VERB
admet-2043	251	20	bbb	bbb	PROPN
admet-2043	251	21	permeability	permeability	NOUN
admet-2043	251	22	since	since	SCONJ
admet-2043	251	23	tight	tight	ADJ
admet-2043	251	24	junctions	junction	NOUN
admet-2043	251	25	are	be	AUX
admet-2043	251	26	essential	essential	ADJ
admet-2043	251	27	for	for	ADP
admet-2043	251	28	preserving	preserve	VERB
admet-2043	251	29	bbb	bbb	PROPN
admet-2043	251	30	integrity	integrity	NOUN
admet-2043	251	31	and	and	CCONJ
admet-2043	251	32	preventing	prevent	VERB
admet-2043	251	33	substances	substance	NOUN
admet-2043	251	34	from	from	ADP
admet-2043	251	35	entering	enter	VERB
admet-2043	251	36	the	the	DET
admet-2043	251	37	brain	brain	NOUN
admet-2043	252	1	[	[	X
admet-2043	252	2	49	49	NUM
admet-2043	252	3	]	]	PUNCT
admet-2043	252	4	.	.	PUNCT
admet-2043	253	1	four	four	NUM
admet-2043	253	2	subtypes	subtype	NOUN
admet-2043	253	3	of	of	ADP
admet-2043	253	4	adenosine	adenosine	ADJ
admet-2043	253	5	receptors	receptor	NOUN
admet-2043	253	6	known	know	VERB
admet-2043	253	7	as	as	ADP
admet-2043	253	8	g	g	NOUN
admet-2043	253	9	-	-	PUNCT
admet-2043	253	10	protein	protein	NOUN
admet-2043	253	11	-	-	PUNCT
admet-2043	253	12	coupled	couple	VERB
admet-2043	253	13	receptors	receptor	NOUN
admet-2043	253	14	are	be	AUX
admet-2043	253	15	recognised	recognise	VERB
admet-2043	253	16	:	:	PUNCT
admet-2043	253	17	a1	a1	NOUN
admet-2043	253	18	,	,	PUNCT
admet-2043	253	19	a2a	a2a	PROPN
admet-2043	253	20	,	,	PUNCT
admet-2043	253	21	a2b	a2b	PROPN
admet-2043	253	22	,	,	PUNCT
admet-2043	253	23	and	and	CCONJ
admet-2043	253	24	a3	a3	VERB
admet-2043	254	1	[	[	X
admet-2043	254	2	76	76	NUM
admet-2043	254	3	]	]	PUNCT
admet-2043	254	4	.	.	PUNCT
admet-2043	255	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	255	2	m.	m.	NOUN
admet-2043	255	3	kulkarni	kulkarni	PROPN
admet-2043	255	4	et	et	PROPN
admet-2043	255	5	al	al	PROPN
admet-2043	255	6	.	.	PROPN
admet-2043	255	7	admet	admet	PROPN
admet-2043	255	8	&	&	CCONJ
admet-2043	255	9	dmpk	dmpk	PROPN
admet-2043	255	10	12(1	12(1	PROPN
admet-2043	255	11	)	)	PUNCT
admet-2043	255	12	(	(	PUNCT
admet-2043	255	13	2024	2024	NUM
admet-2043	255	14	)	)	PUNCT
admet-2043	255	15	63	63	NUM
admet-2043	255	16	-	-	SYM
admet-2043	255	17	105	105	NUM
admet-2043	255	18	74	74	NUM
admet-2043	255	19	a	a	DET
admet-2043	255	20	plethora	plethora	NOUN
admet-2043	255	21	of	of	ADP
admet-2043	255	22	adenosine	adenosine	ADJ
admet-2043	255	23	receptor	receptor	NOUN
admet-2043	255	24	agonists	agonist	NOUN
admet-2043	255	25	and	and	CCONJ
admet-2043	255	26	antagonists	antagonist	NOUN
admet-2043	255	27	exhibiting	exhibit	VERB
admet-2043	255	28	therapeutic	therapeutic	ADJ
admet-2043	255	29	attributes	attribute	NOUN
admet-2043	255	30	can	can	AUX
admet-2043	255	31	be	be	AUX
admet-2043	255	32	observed	observe	VERB
admet-2043	255	33	in	in	ADP
admet-2043	255	34	the	the	DET
admet-2043	255	35	current	current	ADJ
admet-2043	255	36	scientific	scientific	ADJ
admet-2043	255	37	literature	literature	NOUN
admet-2043	255	38	[	[	X
admet-2043	255	39	77	77	NUM
admet-2043	255	40	]	]	PUNCT
admet-2043	255	41	.	.	PUNCT
admet-2043	256	1	gao	gao	PROPN
admet-2043	256	2	et	et	PROPN
admet-2043	256	3	al	al	PROPN
admet-2043	256	4	.	.	PROPN
admet-2043	256	5	have	have	AUX
admet-2043	256	6	recently	recently	ADV
admet-2043	256	7	proven	prove	VERB
admet-2043	256	8	that	that	SCONJ
admet-2043	256	9	turning	turn	VERB
admet-2043	256	10	on	on	ADP
admet-2043	256	11	the	the	DET
admet-2043	256	12	a1	a1	NOUN
admet-2043	256	13	and	and	CCONJ
admet-2043	256	14	a2a	a2a	NOUN
admet-2043	256	15	adenosine	adenosine	NOUN
admet-2043	256	16	receptors	receptor	NOUN
admet-2043	256	17	can	can	AUX
admet-2043	256	18	make	make	VERB
admet-2043	256	19	the	the	DET
admet-2043	256	20	bbb	bbb	NOUN
admet-2043	256	21	more	more	ADV
admet-2043	256	22	permeable	permeable	ADJ
admet-2043	256	23	in	in	ADP
admet-2043	256	24	vivo	vivo	NOUN
admet-2043	256	25	.	.	PUNCT
admet-2043	257	1	one	one	NUM
admet-2043	257	2	a2a	a2a	PROPN
admet-2043	257	3	agonist	agonist	NOUN
admet-2043	257	4	,	,	PUNCT
admet-2043	257	5	lexiscan	lexiscan	PROPN
admet-2043	257	6	,	,	PUNCT
admet-2043	257	7	may	may	AUX
admet-2043	257	8	enhance	enhance	VERB
admet-2043	257	9	macromolecule	macromolecule	ADJ
admet-2043	257	10	penetration	penetration	NOUN
admet-2043	257	11	through	through	ADP
admet-2043	257	12	the	the	DET
admet-2043	257	13	bbb	bbb	PROPN
admet-2043	257	14	.	.	PUNCT
admet-2043	258	1	adenosine	adenosine	ADJ
admet-2043	258	2	receptor	receptor	NOUN
admet-2043	258	3	agonists	agonist	NOUN
admet-2043	258	4	might	might	AUX
admet-2043	258	5	be	be	AUX
admet-2043	258	6	used	use	VERB
admet-2043	258	7	to	to	PART
admet-2043	258	8	transport	transport	VERB
admet-2043	258	9	medications	medication	NOUN
admet-2043	258	10	to	to	ADP
admet-2043	258	11	the	the	DET
admet-2043	258	12	brain	brain	NOUN
admet-2043	259	1	[	[	X
admet-2043	259	2	78	78	NUM
admet-2043	259	3	,	,	PUNCT
admet-2043	259	4	79	79	NUM
admet-2043	259	5	]	]	PUNCT
admet-2043	259	6	.	.	PUNCT
admet-2043	260	1	the	the	DET
admet-2043	260	2	use	use	NOUN
admet-2043	260	3	of	of	ADP
admet-2043	260	4	lexiscan	lexiscan	PROPN
admet-2043	260	5	-	-	PUNCT
admet-2043	260	6	conjugated	conjugate	VERB
admet-2043	260	7	dendrimers	dendrimer	NOUN
admet-2043	260	8	resulted	result	VERB
admet-2043	260	9	in	in	ADP
admet-2043	260	10	the	the	DET
admet-2043	260	11	production	production	NOUN
admet-2043	260	12	of	of	ADP
admet-2043	260	13	nano	nano	NOUN
admet-2043	260	14	agonists	agonist	NOUN
admet-2043	260	15	that	that	PRON
admet-2043	260	16	improved	improve	VERB
admet-2043	260	17	the	the	DET
admet-2043	260	18	targeted	target	VERB
admet-2043	260	19	delivery	delivery	NOUN
admet-2043	260	20	of	of	ADP
admet-2043	260	21	several	several	ADJ
admet-2043	260	22	model	model	NOUN
admet-2043	260	23	medicines	medicine	NOUN
admet-2043	260	24	(	(	PUNCT
admet-2043	260	25	nas	nas	PROPN
admet-2043	260	26	)	)	PUNCT
admet-2043	260	27	.	.	PUNCT
admet-2043	261	1	den	den	NOUN
admet-2043	261	2	-	-	PUNCT
admet-2043	261	3	reg16	reg16	NOUN
admet-2043	261	4	,	,	PUNCT
admet-2043	261	5	which	which	PRON
admet-2043	261	6	combines	combine	VERB
admet-2043	261	7	16	16	NUM
admet-2043	261	8	lexiscan	lexiscan	ADJ
admet-2043	261	9	molecules	molecule	NOUN
admet-2043	261	10	onto	onto	ADP
admet-2043	261	11	one	one	NUM
admet-2043	261	12	dendrimer	dendrimer	NOUN
admet-2043	261	13	,	,	PUNCT
admet-2043	261	14	has	have	VERB
admet-2043	261	15	a	a	DET
admet-2043	261	16	7.7	7.7	NUM
admet-2043	261	17	-	-	ADJ
admet-2043	261	18	fold	fold	ADJ
admet-2043	261	19	higher	high	ADJ
admet-2043	261	20	affinity	affinity	NOUN
admet-2043	261	21	for	for	ADP
admet-2043	261	22	the	the	DET
admet-2043	261	23	a2a	a2a	PROPN
admet-2043	261	24	adenosine	adenosine	NOUN
admet-2043	261	25	receptor	receptor	NOUN
admet-2043	261	26	than	than	ADP
admet-2043	261	27	unaltered	unaltered	ADJ
admet-2043	261	28	lexiscan	lexiscan	NOUN
admet-2043	261	29	.	.	PUNCT
admet-2043	262	1	in	in	ADP
admet-2043	262	2	untreated	untreated	ADJ
admet-2043	262	3	bend.3	bend.3	PROPN
admet-2043	262	4	monolayers	monolayer	NOUN
admet-2043	262	5	,	,	PUNCT
admet-2043	262	6	zo-1	zo-1	NUM
admet-2043	262	7	expression	expression	NOUN
admet-2043	262	8	was	be	AUX
admet-2043	262	9	continuously	continuously	ADV
admet-2043	262	10	aligned	align	VERB
admet-2043	262	11	on	on	ADP
admet-2043	262	12	the	the	DET
admet-2043	262	13	cell	cell	NOUN
admet-2043	262	14	-	-	PUNCT
admet-2043	262	15	cell	cell	NOUN
admet-2043	262	16	interface	interface	NOUN
admet-2043	262	17	in	in	ADP
admet-2043	262	18	vitro	vitro	NOUN
admet-2043	262	19	;	;	PUNCT
admet-2043	262	20	however	however	ADV
admet-2043	262	21	,	,	PUNCT
admet-2043	262	22	den	den	ADJ
admet-2043	262	23	-	-	PUNCT
admet-2043	262	24	reg16	reg16	NOUN
admet-2043	262	25	treatment	treatment	NOUN
admet-2043	262	26	halted	halt	VERB
admet-2043	262	27	expression	expression	NOUN
admet-2043	262	28	and	and	CCONJ
admet-2043	262	29	increased	increase	VERB
admet-2043	262	30	the	the	DET
admet-2043	262	31	permeability	permeability	NOUN
admet-2043	262	32	of	of	ADP
admet-2043	262	33	the	the	DET
admet-2043	262	34	model	model	NOUN
admet-2043	262	35	drug	drug	NOUN
admet-2043	262	36	by	by	ADP
admet-2043	262	37	17.6	17.6	NUM
admet-2043	262	38	times	time	NOUN
admet-2043	262	39	.	.	PUNCT
admet-2043	263	1	in	in	ADP
admet-2043	263	2	mice	mouse	NOUN
admet-2043	263	3	pretreated	pretreate	VERB
admet-2043	263	4	with	with	ADP
admet-2043	263	5	den	den	NOUN
admet-2043	263	6	-	-	PUNCT
admet-2043	263	7	reg16	reg16	NOUN
admet-2043	263	8	,	,	PUNCT
admet-2043	263	9	the	the	DET
admet-2043	263	10	model	model	NOUN
admet-2043	263	11	drug	drug	NOUN
admet-2043	263	12	accumulation	accumulation	NOUN
admet-2043	263	13	in	in	ADP
admet-2043	263	14	the	the	DET
admet-2043	263	15	brains	brain	NOUN
admet-2043	263	16	was	be	AUX
admet-2043	263	17	6.8	6.8	NUM
admet-2043	263	18	and	and	CCONJ
admet-2043	263	19	3.6	3.6	NUM
admet-2043	263	20	times	time	NOUN
admet-2043	263	21	greater	great	ADJ
admet-2043	263	22	than	than	ADP
admet-2043	263	23	in	in	ADP
admet-2043	263	24	saline	saline	NOUN
admet-2043	263	25	with	with	ADP
admet-2043	263	26	lexiscan	lexiscan	PROPN
admet-2043	263	27	,	,	PUNCT
admet-2043	263	28	respectively	respectively	ADV
admet-2043	263	29	.	.	PUNCT
admet-2043	264	1	additionally	additionally	ADV
admet-2043	264	2	,	,	PUNCT
admet-2043	264	3	there	there	PRON
admet-2043	264	4	is	be	VERB
admet-2043	264	5	an	an	DET
admet-2043	264	6	increase	increase	NOUN
admet-2043	264	7	in	in	ADP
admet-2043	264	8	brain	brain	NOUN
admet-2043	264	9	-	-	PUNCT
admet-2043	264	10	focused	focus	VERB
admet-2043	264	11	drug	drug	NOUN
admet-2043	264	12	delivery	delivery	NOUN
admet-2043	264	13	as	as	SCONJ
admet-2043	264	14	measured	measure	VERB
admet-2043	264	15	by	by	ADP
admet-2043	264	16	spect	spect	NOUN
admet-2043	264	17	/	/	SYM
admet-2043	264	18	ct	ct	PROPN
admet-2043	265	1	[	[	X
admet-2043	265	2	79	79	NUM
admet-2043	265	3	]	]	PUNCT
admet-2043	265	4	.	.	PUNCT
admet-2043	266	1	the	the	DET
admet-2043	266	2	nanoagonists	nanoagonist	NOUN
admet-2043	266	3	were	be	AUX
admet-2043	266	4	found	find	VERB
admet-2043	266	5	to	to	PART
admet-2043	266	6	be	be	AUX
admet-2043	266	7	promising	promise	VERB
admet-2043	266	8	adjuvants	adjuvant	NOUN
admet-2043	266	9	for	for	ADP
admet-2043	266	10	enhancing	enhance	VERB
admet-2043	266	11	bbb	bbb	PROPN
admet-2043	266	12	permeability	permeability	NOUN
admet-2043	266	13	.	.	PUNCT
admet-2043	267	1	tight	tight	ADJ
admet-2043	267	2	junction	junction	NOUN
admet-2043	267	3	transition	transition	NOUN
admet-2043	267	4	mediated	mediate	VERB
admet-2043	267	5	by	by	ADP
admet-2043	267	6	receptors	receptor	NOUN
admet-2043	267	7	has	have	VERB
admet-2043	267	8	various	various	ADJ
admet-2043	267	9	advantages	advantage	NOUN
admet-2043	267	10	for	for	ADP
admet-2043	267	11	medication	medication	NOUN
admet-2043	267	12	administration	administration	NOUN
admet-2043	267	13	across	across	ADP
admet-2043	267	14	the	the	DET
admet-2043	267	15	bbb	bbb	PROPN
admet-2043	267	16	.	.	PUNCT
admet-2043	268	1	by	by	ADP
admet-2043	268	2	modulating	modulate	VERB
admet-2043	268	3	the	the	DET
admet-2043	268	4	permeability	permeability	NOUN
admet-2043	268	5	of	of	ADP
admet-2043	268	6	the	the	DET
admet-2043	268	7	barrier	barrier	NOUN
admet-2043	268	8	at	at	ADP
admet-2043	268	9	predetermined	predetermine	VERB
admet-2043	268	10	locations	location	NOUN
admet-2043	268	11	it	it	PRON
admet-2043	268	12	enables	enable	VERB
admet-2043	268	13	the	the	DET
admet-2043	268	14	precise	precise	ADJ
admet-2043	268	15	and	and	CCONJ
admet-2043	268	16	targeted	target	VERB
admet-2043	268	17	delivery	delivery	NOUN
admet-2043	268	18	of	of	ADP
admet-2043	268	19	therapeutic	therapeutic	ADJ
admet-2043	268	20	agents	agent	NOUN
admet-2043	268	21	to	to	ADP
admet-2043	268	22	specific	specific	ADJ
admet-2043	268	23	tissues	tissue	NOUN
admet-2043	268	24	or	or	CCONJ
admet-2043	268	25	cells	cell	NOUN
admet-2043	268	26	.	.	PUNCT
admet-2043	269	1	receptor	receptor	NOUN
admet-2043	269	2	-	-	PUNCT
admet-2043	269	3	mediated	mediate	VERB
admet-2043	269	4	modulation	modulation	NOUN
admet-2043	269	5	,	,	PUNCT
admet-2043	269	6	owing	owe	VERB
admet-2043	269	7	to	to	ADP
admet-2043	269	8	its	its	PRON
admet-2043	269	9	inherent	inherent	ADJ
admet-2043	269	10	reversibility	reversibility	NOUN
admet-2043	269	11	,	,	PUNCT
admet-2043	269	12	affords	afford	VERB
admet-2043	269	13	the	the	DET
admet-2043	269	14	advantageous	advantageous	ADJ
admet-2043	269	15	capacity	capacity	NOUN
admet-2043	269	16	for	for	ADP
admet-2043	269	17	temporal	temporal	ADJ
admet-2043	269	18	regulation	regulation	NOUN
admet-2043	269	19	and	and	CCONJ
admet-2043	269	20	adaptability	adaptability	NOUN
admet-2043	269	21	in	in	ADP
admet-2043	269	22	the	the	DET
admet-2043	269	23	realm	realm	NOUN
admet-2043	269	24	of	of	ADP
admet-2043	269	25	pharmaceutical	pharmaceutical	NOUN
admet-2043	269	26	administration	administration	NOUN
admet-2043	269	27	[	[	X
admet-2043	269	28	80	80	NUM
admet-2043	269	29	]	]	PUNCT
admet-2043	269	30	.	.	PUNCT
admet-2043	270	1	nevertheless	nevertheless	ADV
admet-2043	270	2	,	,	PUNCT
admet-2043	270	3	it	it	PRON
admet-2043	270	4	is	be	AUX
admet-2043	270	5	imperative	imperative	ADJ
admet-2043	270	6	to	to	PART
admet-2043	270	7	acknowledge	acknowledge	VERB
admet-2043	270	8	certain	certain	ADJ
admet-2043	270	9	constraints	constraint	NOUN
admet-2043	270	10	inherent	inherent	ADJ
admet-2043	270	11	in	in	ADP
admet-2043	270	12	this	this	DET
admet-2043	270	13	approach	approach	NOUN
admet-2043	270	14	.	.	PUNCT
admet-2043	271	1	these	these	DET
admet-2043	271	2	limitations	limitation	NOUN
admet-2043	271	3	encompass	encompass	VERB
admet-2043	271	4	the	the	DET
admet-2043	271	5	absence	absence	NOUN
admet-2043	271	6	of	of	ADP
admet-2043	271	7	suitable	suitable	ADJ
admet-2043	271	8	receptors	receptor	NOUN
admet-2043	271	9	within	within	ADP
admet-2043	271	10	the	the	DET
admet-2043	271	11	targeted	target	VERB
admet-2043	271	12	region	region	NOUN
admet-2043	271	13	,	,	PUNCT
admet-2043	271	14	the	the	DET
admet-2043	271	15	potential	potential	NOUN
admet-2043	271	16	for	for	ADP
admet-2043	271	17	unintended	unintended	ADJ
admet-2043	271	18	consequences	consequence	NOUN
admet-2043	271	19	on	on	ADP
admet-2043	271	20	unrelated	unrelated	ADJ
admet-2043	271	21	biological	biological	ADJ
admet-2043	271	22	pathways	pathway	NOUN
admet-2043	271	23	or	or	CCONJ
admet-2043	271	24	tissues	tissue	NOUN
admet-2043	271	25	,	,	PUNCT
admet-2043	271	26	the	the	DET
admet-2043	271	27	inherent	inherent	ADJ
admet-2043	271	28	variability	variability	NOUN
admet-2043	271	29	in	in	ADP
admet-2043	271	30	receptor	receptor	NOUN
admet-2043	271	31	expression	expression	NOUN
admet-2043	271	32	across	across	ADP
admet-2043	271	33	the	the	DET
admet-2043	271	34	blood	blood	NOUN
admet-2043	271	35	-	-	PUNCT
admet-2043	271	36	brain	brain	NOUN
admet-2043	271	37	barrier	barrier	NOUN
admet-2043	271	38	(	(	PUNCT
admet-2043	271	39	bbb	bbb	NOUN
admet-2043	271	40	)	)	PUNCT
admet-2043	271	41	,	,	PUNCT
admet-2043	271	42	and	and	CCONJ
admet-2043	271	43	the	the	DET
admet-2043	271	44	indispensable	indispensable	ADJ
admet-2043	271	45	requirement	requirement	NOUN
admet-2043	271	46	for	for	ADP
admet-2043	271	47	meticulous	meticulous	ADJ
admet-2043	271	48	adherence	adherence	NOUN
admet-2043	271	49	to	to	ADP
admet-2043	271	50	regulatory	regulatory	ADJ
admet-2043	271	51	and	and	CCONJ
admet-2043	271	52	safety	safety	NOUN
admet-2043	271	53	protocols	protocol	NOUN
admet-2043	271	54	[	[	X
admet-2043	271	55	81	81	NUM
admet-2043	271	56	]	]	PUNCT
admet-2043	271	57	.	.	PUNCT
admet-2043	272	1	focused	focus	VERB
admet-2043	272	2	ultrasound	ultrasound	PROPN
admet-2043	272	3	ultrasound	ultrasound	PROPN
admet-2043	272	4	has	have	AUX
admet-2043	272	5	emerged	emerge	VERB
admet-2043	272	6	as	as	ADP
admet-2043	272	7	a	a	DET
admet-2043	272	8	progressively	progressively	ADV
admet-2043	272	9	favoured	favour	VERB
admet-2043	272	10	modality	modality	NOUN
admet-2043	272	11	for	for	ADP
admet-2043	272	12	facilitating	facilitate	VERB
admet-2043	272	13	the	the	DET
admet-2043	272	14	permeation	permeation	NOUN
admet-2043	272	15	of	of	ADP
admet-2043	272	16	pharmaceutical	pharmaceutical	ADJ
admet-2043	272	17	agents	agent	NOUN
admet-2043	272	18	across	across	ADP
admet-2043	272	19	the	the	DET
admet-2043	272	20	bbb	bbb	PROPN
admet-2043	272	21	.	.	PUNCT
admet-2043	273	1	microbubble	microbubble	ADJ
admet-2043	273	2	-	-	PUNCT
admet-2043	273	3	enhanced	enhance	VERB
admet-2043	273	4	diagnostic	diagnostic	ADJ
admet-2043	273	5	ultrasonography	ultrasonography	NOUN
admet-2043	273	6	(	(	PUNCT
admet-2043	273	7	meus	meus	NOUN
admet-2043	273	8	)	)	PUNCT
admet-2043	273	9	is	be	AUX
admet-2043	273	10	a	a	DET
admet-2043	273	11	non	non	ADJ
admet-2043	273	12	-	-	ADJ
admet-2043	273	13	invasive	invasive	ADJ
admet-2043	273	14	modality	modality	NOUN
admet-2043	273	15	employed	employ	VERB
admet-2043	273	16	to	to	PART
admet-2043	273	17	augment	augment	VERB
admet-2043	273	18	the	the	DET
admet-2043	273	19	permeability	permeability	NOUN
admet-2043	273	20	of	of	ADP
admet-2043	273	21	the	the	DET
admet-2043	273	22	blood	blood	NOUN
admet-2043	273	23	-	-	PUNCT
admet-2043	273	24	brain	brain	NOUN
admet-2043	273	25	tumour	tumour	NOUN
admet-2043	273	26	barrier	barrier	NOUN
admet-2043	273	27	(	(	PUNCT
admet-2043	273	28	bbtb	bbtb	NOUN
admet-2043	273	29	)	)	PUNCT
admet-2043	273	30	in	in	ADP
admet-2043	273	31	individuals	individual	NOUN
admet-2043	273	32	diagnosed	diagnose	VERB
admet-2043	273	33	with	with	ADP
admet-2043	273	34	glioma	glioma	NOUN
admet-2043	273	35	.	.	PUNCT
admet-2043	274	1	the	the	DET
admet-2043	274	2	primary	primary	ADJ
admet-2043	274	3	objective	objective	NOUN
admet-2043	274	4	of	of	ADP
admet-2043	274	5	this	this	DET
admet-2043	274	6	technique	technique	NOUN
admet-2043	274	7	is	be	AUX
admet-2043	274	8	to	to	PART
admet-2043	274	9	facilitate	facilitate	VERB
admet-2043	274	10	the	the	DET
admet-2043	274	11	passage	passage	NOUN
admet-2043	274	12	of	of	ADP
admet-2043	274	13	therapeutic	therapeutic	ADJ
admet-2043	274	14	agents	agent	NOUN
admet-2043	274	15	across	across	ADP
admet-2043	274	16	the	the	DET
admet-2043	274	17	bbtb	bbtb	NOUN
admet-2043	274	18	,	,	PUNCT
admet-2043	274	19	thereby	thereby	ADV
admet-2043	274	20	enhancing	enhance	VERB
admet-2043	274	21	the	the	DET
admet-2043	274	22	efficacy	efficacy	NOUN
admet-2043	274	23	of	of	ADP
admet-2043	274	24	medication	medication	NOUN
admet-2043	274	25	delivery	delivery	NOUN
admet-2043	274	26	.	.	PUNCT
admet-2043	275	1	the	the	DET
admet-2043	275	2	utilisation	utilisation	NOUN
admet-2043	275	3	of	of	ADP
admet-2043	275	4	focused	focused	ADJ
admet-2043	275	5	ultrasound	ultrasound	NOUN
admet-2043	275	6	(	(	PUNCT
admet-2043	275	7	fus	fus	NOUN
admet-2043	275	8	)	)	PUNCT
admet-2043	275	9	has	have	AUX
admet-2043	275	10	demonstrated	demonstrate	VERB
admet-2043	275	11	its	its	PRON
admet-2043	275	12	efficacy	efficacy	NOUN
admet-2043	275	13	in	in	ADP
admet-2043	275	14	augmenting	augment	VERB
admet-2043	275	15	the	the	DET
admet-2043	275	16	transport	transport	NOUN
admet-2043	275	17	of	of	ADP
admet-2043	275	18	np	np	ADP
admet-2043	275	19	cargo	cargo	NOUN
admet-2043	275	20	across	across	ADP
admet-2043	275	21	the	the	DET
admet-2043	275	22	bbb	bbb	NOUN
admet-2043	276	1	[	[	X
admet-2043	276	2	120	120	NUM
admet-2043	276	3	]	]	PUNCT
admet-2043	276	4	.	.	PUNCT
admet-2043	277	1	etame	etame	PROPN
admet-2043	277	2	et	et	PROPN
admet-2043	277	3	al	al	PROPN
admet-2043	277	4	.	.	PUNCT
admet-2043	278	1	[	[	X
admet-2043	278	2	12	12	NUM
admet-2043	278	3	]	]	PUNCT
admet-2043	278	4	used	use	VERB
admet-2043	278	5	targeted	target	VERB
admet-2043	278	6	ultrasound	ultrasound	NOUN
admet-2043	278	7	that	that	PRON
admet-2043	278	8	was	be	AUX
admet-2043	278	9	guided	guide	VERB
admet-2043	278	10	by	by	ADP
admet-2043	278	11	an	an	DET
admet-2043	278	12	mri	mri	NOUN
admet-2043	278	13	to	to	PART
admet-2043	278	14	look	look	VERB
admet-2043	278	15	at	at	ADP
admet-2043	278	16	the	the	DET
admet-2043	278	17	distribution	distribution	NOUN
admet-2043	278	18	of	of	ADP
admet-2043	278	19	gold	gold	ADJ
admet-2043	278	20	nanoparticles	nanoparticle	NOUN
admet-2043	278	21	in	in	ADP
admet-2043	278	22	two	two	NUM
admet-2043	278	23	hemispheres	hemisphere	NOUN
admet-2043	278	24	.	.	PUNCT
admet-2043	279	1	in	in	ADP
admet-2043	279	2	comparison	comparison	NOUN
admet-2043	279	3	to	to	ADP
admet-2043	279	4	the	the	DET
admet-2043	279	5	control	control	NOUN
admet-2043	279	6	hemisphere	hemisphere	ADV
admet-2043	279	7	,	,	PUNCT
admet-2043	279	8	the	the	DET
admet-2043	279	9	concentration	concentration	NOUN
admet-2043	279	10	of	of	ADP
admet-2043	279	11	gold	gold	PROPN
admet-2043	279	12	nps	nps	PROPN
admet-2043	279	13	was	be	AUX
admet-2043	279	14	3.36	3.36	NUM
admet-2043	279	15	times	time	NOUN
admet-2043	279	16	greater	great	ADJ
admet-2043	279	17	in	in	ADP
admet-2043	279	18	the	the	DET
admet-2043	279	19	sonicated	sonicate	VERB
admet-2043	279	20	hemisphere	hemisphere	ADV
admet-2043	279	21	.	.	PUNCT
admet-2043	280	1	this	this	PRON
admet-2043	280	2	demonstrates	demonstrate	VERB
admet-2043	280	3	how	how	SCONJ
admet-2043	280	4	therapeutic	therapeutic	ADJ
admet-2043	280	5	gold	gold	NOUN
admet-2043	280	6	nanoparticle	nanoparticle	NOUN
admet-2043	280	7	transport	transport	NOUN
admet-2043	280	8	into	into	ADP
admet-2043	280	9	the	the	DET
admet-2043	280	10	brain	brain	NOUN
admet-2043	280	11	may	may	AUX
admet-2043	280	12	be	be	AUX
admet-2043	280	13	enhanced	enhance	VERB
admet-2043	280	14	by	by	ADP
admet-2043	280	15	mri	mri	NOUN
admet-2043	280	16	-	-	PUNCT
admet-2043	280	17	guided	guide	VERB
admet-2043	280	18	focused	focus	VERB
admet-2043	280	19	ultrasound	ultrasound	NOUN
admet-2043	280	20	.	.	PUNCT
admet-2043	281	1	through	through	ADP
admet-2043	281	2	the	the	DET
admet-2043	281	3	use	use	NOUN
admet-2043	281	4	of	of	ADP
admet-2043	281	5	fus	fus	NUM
admet-2043	281	6	and	and	CCONJ
admet-2043	281	7	microbubbles	microbubble	VERB
admet-2043	281	8	in	in	ADP
admet-2043	281	9	conjunction	conjunction	NOUN
admet-2043	281	10	with	with	ADP
admet-2043	281	11	dce	dce	PROPN
admet-2043	281	12	-	-	PUNCT
admet-2043	281	13	mri	mri	NOUN
admet-2043	281	14	,	,	PUNCT
admet-2043	281	15	park	park	NOUN
admet-2043	281	16	et	et	PROPN
admet-2043	281	17	al	al	PROPN
admet-2043	281	18	.	.	PUNCT
admet-2043	282	1	[	[	X
admet-2043	282	2	82	82	NUM
admet-2043	282	3	]	]	PUNCT
admet-2043	282	4	studied	study	VERB
admet-2043	282	5	the	the	DET
admet-2043	282	6	delivery	delivery	NOUN
admet-2043	282	7	of	of	ADP
admet-2043	282	8	doxorubicin	doxorubicin	PROPN
admet-2043	282	9	.	.	PUNCT
admet-2043	283	1	by	by	ADP
admet-2043	283	2	combining	combine	VERB
admet-2043	283	3	the	the	DET
admet-2043	283	4	two	two	NUM
admet-2043	283	5	methods	method	NOUN
admet-2043	283	6	,	,	PUNCT
admet-2043	283	7	they	they	PRON
admet-2043	283	8	were	be	AUX
admet-2043	283	9	able	able	ADJ
admet-2043	283	10	to	to	PART
admet-2043	283	11	show	show	VERB
admet-2043	283	12	that	that	SCONJ
admet-2043	283	13	the	the	DET
admet-2043	283	14	bbb	bbb	NOUN
admet-2043	283	15	and	and	CCONJ
admet-2043	283	16	bbtb	bbtb	NOUN
admet-2043	283	17	were	be	AUX
admet-2043	283	18	more	more	ADV
admet-2043	283	19	permeable	permeable	ADJ
admet-2043	283	20	to	to	ADP
admet-2043	283	21	drugs	drug	NOUN
admet-2043	283	22	and	and	CCONJ
admet-2043	283	23	that	that	SCONJ
admet-2043	283	24	the	the	DET
admet-2043	283	25	drug	drug	NOUN
admet-2043	283	26	retention	retention	NOUN
admet-2043	283	27	period	period	NOUN
admet-2043	283	28	in	in	ADP
admet-2043	283	29	tissue	tissue	NOUN
admet-2043	283	30	over	over	ADP
admet-2043	283	31	24	24	NUM
admet-2043	283	32	hours	hour	NOUN
admet-2043	283	33	was	be	AUX
admet-2043	283	34	enhanced	enhance	VERB
admet-2043	283	35	.	.	PUNCT
admet-2043	284	1	meus	meus	NOUN
admet-2043	284	2	'	'	PART
admet-2043	284	3	capacity	capacity	NOUN
admet-2043	284	4	to	to	PART
admet-2043	284	5	reduce	reduce	VERB
admet-2043	284	6	p	p	NOUN
admet-2043	284	7	-	-	PUNCT
admet-2043	284	8	gp	gp	NOUN
admet-2043	284	9	expression	expression	NOUN
admet-2043	284	10	over	over	ADP
admet-2043	284	11	time	time	NOUN
admet-2043	284	12	was	be	AUX
admet-2043	284	13	equally	equally	ADV
admet-2043	284	14	fascinating	fascinating	ADJ
admet-2043	284	15	.	.	PUNCT
admet-2043	285	1	nonhuman	nonhuman	ADJ
admet-2043	285	2	primates	primate	NOUN
admet-2043	285	3	were	be	AUX
admet-2043	285	4	given	give	VERB
admet-2043	285	5	fus	fus	ADP
admet-2043	285	6	at	at	ADP
admet-2043	285	7	different	different	ADJ
admet-2043	285	8	sonic	sonic	ADJ
admet-2043	285	9	pressures	pressure	NOUN
admet-2043	285	10	to	to	PART
admet-2043	285	11	explore	explore	VERB
admet-2043	285	12	the	the	DET
admet-2043	285	13	physiological	physiological	ADJ
admet-2043	285	14	changes	change	NOUN
admet-2043	285	15	in	in	ADP
admet-2043	285	16	the	the	DET
admet-2043	285	17	brain	brain	NOUN
admet-2043	285	18	caused	cause	VERB
admet-2043	285	19	by	by	ADP
admet-2043	285	20	the	the	DET
admet-2043	285	21	fus	fus	ADV
admet-2043	285	22	-	-	PUNCT
admet-2043	285	23	induced	induce	VERB
admet-2043	285	24	bbb	bbb	NOUN
admet-2043	285	25	opening	opening	NOUN
admet-2043	285	26	[	[	X
admet-2043	285	27	83	83	NUM
admet-2043	285	28	]	]	PUNCT
admet-2043	285	29	.	.	PUNCT
admet-2043	286	1	the	the	DET
admet-2043	286	2	buildup	buildup	NOUN
admet-2043	286	3	of	of	ADP
admet-2043	286	4	drugs	drug	NOUN
admet-2043	286	5	and	and	CCONJ
admet-2043	286	6	np	np	INTJ
admet-2043	286	7	in	in	ADP
admet-2043	286	8	the	the	DET
admet-2043	286	9	brain	brain	NOUN
admet-2043	286	10	may	may	AUX
admet-2043	286	11	be	be	AUX
admet-2043	286	12	accelerated	accelerate	VERB
admet-2043	286	13	by	by	ADP
admet-2043	286	14	combining	combine	VERB
admet-2043	286	15	fus	fus	PROPN
admet-2043	286	16	with	with	ADP
admet-2043	286	17	other	other	ADJ
admet-2043	286	18	targeted	target	VERB
admet-2043	286	19	techniques	technique	NOUN
admet-2043	286	20	.	.	PUNCT
admet-2043	287	1	when	when	SCONJ
admet-2043	287	2	fus	fus	PROPN
admet-2043	287	3	and	and	CCONJ
admet-2043	287	4	magnetic	magnetic	ADJ
admet-2043	287	5	targeting	targeting	NOUN
admet-2043	287	6	were	be	AUX
admet-2043	287	7	used	use	VERB
admet-2043	287	8	together	together	ADV
admet-2043	287	9	,	,	PUNCT
admet-2043	287	10	magnetic	magnetic	ADJ
admet-2043	287	11	np	np	ADP
admet-2043	287	12	accumulation	accumulation	NOUN
admet-2043	287	13	in	in	ADP
admet-2043	287	14	the	the	DET
admet-2043	287	15	brain	brain	NOUN
admet-2043	287	16	improved	improve	VERB
admet-2043	287	17	16.3	16.3	NUM
admet-2043	287	18	times	time	NOUN
admet-2043	287	19	more	more	ADJ
admet-2043	287	20	than	than	ADP
admet-2043	287	21	when	when	SCONJ
admet-2043	287	22	fus	fus	PROPN
admet-2043	287	23	was	be	AUX
admet-2043	287	24	used	use	VERB
admet-2043	287	25	alone	alone	ADV
admet-2043	287	26	[	[	X
admet-2043	287	27	84	84	NUM
admet-2043	287	28	]	]	PUNCT
admet-2043	287	29	.	.	PUNCT
admet-2043	288	1	combining	combine	VERB
admet-2043	288	2	fus	fus	NUM
admet-2043	288	3	with	with	ADP
admet-2043	288	4	a	a	DET
admet-2043	288	5	targeting	target	VERB
admet-2043	288	6	ligand	ligand	NOUN
admet-2043	288	7	alteration	alteration	NOUN
admet-2043	288	8	may	may	AUX
admet-2043	288	9	admet	admet	PROPN
admet-2043	288	10	&	&	CCONJ
admet-2043	288	11	dmpk	dmpk	PROPN
admet-2043	288	12	12(1	12(1	PROPN
admet-2043	288	13	)	)	PUNCT
admet-2043	288	14	(	(	PUNCT
admet-2043	288	15	2024	2024	NUM
admet-2043	288	16	)	)	PUNCT
admet-2043	288	17	63	63	NUM
admet-2043	288	18	-	-	SYM
admet-2043	288	19	105	105	NUM
admet-2043	288	20	nanomaterials	nanomaterial	NOUN
admet-2043	288	21	as	as	ADP
admet-2043	288	22	drug	drug	NOUN
admet-2043	288	23	delivery	delivery	NOUN
admet-2043	288	24	agents	agent	NOUN
admet-2043	288	25	for	for	ADP
admet-2043	288	26	overcoming	overcome	VERB
admet-2043	288	27	bbb	bbb	PROPN
admet-2043	288	28	doi	doi	NOUN
admet-2043	288	29	:	:	PUNCT
admet-2043	288	30	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	288	31	75	75	NUM
admet-2043	288	32	potentially	potentially	ADV
admet-2043	288	33	improve	improve	VERB
admet-2043	288	34	brain	brain	NOUN
admet-2043	288	35	-	-	PUNCT
admet-2043	288	36	targeted	target	VERB
admet-2043	288	37	medication	medication	NOUN
admet-2043	288	38	delivery	delivery	NOUN
admet-2043	288	39	.	.	PUNCT
admet-2043	289	1	when	when	SCONJ
admet-2043	289	2	combined	combine	VERB
admet-2043	289	3	with	with	ADP
admet-2043	289	4	atherosclerotic	atherosclerotic	ADJ
admet-2043	289	5	plaque	plaque	NOUN
admet-2043	289	6	-	-	PUNCT
admet-2043	289	7	specific	specific	ADJ
admet-2043	289	8	peptide-1	peptide-1	NOUN
admet-2043	289	9	-	-	PUNCT
admet-2043	289	10	modified	modify	VERB
admet-2043	289	11	liposomes	liposome	NOUN
admet-2043	289	12	,	,	PUNCT
admet-2043	289	13	the	the	DET
admet-2043	289	14	tumor	tumor	NOUN
admet-2043	289	15	-	-	PUNCT
admet-2043	289	16	to	to	ADP
admet-2043	289	17	-	-	PUNCT
admet-2043	289	18	contralateral	contralateral	ADJ
admet-2043	289	19	brain	brain	NOUN
admet-2043	289	20	ratios	ratio	NOUN
admet-2043	289	21	of	of	ADP
admet-2043	289	22	medication	medication	NOUN
admet-2043	289	23	rose	rise	VERB
admet-2043	289	24	from	from	ADP
admet-2043	289	25	2.1	2.1	NUM
admet-2043	289	26	to	to	ADP
admet-2043	289	27	3.8	3.8	NUM
admet-2043	289	28	.	.	PUNCT
admet-2043	290	1	fus	fus	ADJ
admet-2043	290	2	toxicity	toxicity	NOUN
admet-2043	290	3	to	to	ADP
admet-2043	290	4	the	the	DET
admet-2043	290	5	brain	brain	NOUN
admet-2043	290	6	is	be	AUX
admet-2043	290	7	considered	consider	VERB
admet-2043	290	8	minimal	minimal	ADJ
admet-2043	290	9	,	,	PUNCT
admet-2043	290	10	and	and	CCONJ
admet-2043	290	11	neurotoxicity	neurotoxicity	NOUN
admet-2043	290	12	was	be	AUX
admet-2043	290	13	not	not	PART
admet-2043	290	14	seen	see	VERB
admet-2043	290	15	in	in	ADP
admet-2043	290	16	recent	recent	ADJ
admet-2043	290	17	research	research	NOUN
admet-2043	290	18	[	[	X
admet-2043	290	19	85	85	NUM
admet-2043	290	20	]	]	PUNCT
admet-2043	290	21	.	.	PUNCT
admet-2043	291	1	most	most	ADJ
admet-2043	291	2	patients	patient	NOUN
admet-2043	291	3	showed	show	VERB
admet-2043	291	4	no	no	DET
admet-2043	291	5	oedema	oedema	NOUN
admet-2043	291	6	after	after	ADP
admet-2043	291	7	using	use	VERB
admet-2043	291	8	fus	fus	PROPN
admet-2043	291	9	and	and	CCONJ
admet-2043	291	10	microbubbles	microbubble	VERB
admet-2043	291	11	to	to	PART
admet-2043	291	12	repeatedly	repeatedly	ADV
admet-2043	291	13	breach	breach	VERB
admet-2043	291	14	the	the	DET
admet-2043	291	15	bbb	bbb	NOUN
admet-2043	291	16	over	over	ADP
admet-2043	291	17	an	an	DET
admet-2043	291	18	extended	extended	ADJ
admet-2043	291	19	period	period	NOUN
admet-2043	291	20	(	(	PUNCT
admet-2043	291	21	4	4	NUM
admet-2043	291	22	to	to	PART
admet-2043	291	23	20	20	NUM
admet-2043	291	24	months	month	NOUN
admet-2043	291	25	)	)	PUNCT
admet-2043	291	26	.	.	PUNCT
admet-2043	292	1	there	there	PRON
admet-2043	292	2	should	should	AUX
admet-2043	292	3	be	be	AUX
admet-2043	292	4	caution	caution	NOUN
admet-2043	292	5	while	while	SCONJ
admet-2043	292	6	using	use	VERB
admet-2043	292	7	this	this	DET
admet-2043	292	8	technology	technology	NOUN
admet-2043	292	9	for	for	ADP
admet-2043	292	10	medicinal	medicinal	ADJ
admet-2043	292	11	purposes	purpose	NOUN
admet-2043	292	12	[	[	X
admet-2043	292	13	86	86	NUM
admet-2043	292	14	]	]	PUNCT
admet-2043	292	15	.	.	PUNCT
admet-2043	293	1	however	however	ADV
admet-2043	293	2	,	,	PUNCT
admet-2043	293	3	a	a	DET
admet-2043	293	4	substantial	substantial	ADJ
admet-2043	293	5	increase	increase	NOUN
admet-2043	293	6	in	in	ADP
admet-2043	293	7	reaction	reaction	NOUN
admet-2043	293	8	time	time	NOUN
admet-2043	293	9	during	during	ADP
admet-2043	293	10	the	the	DET
admet-2043	293	11	task	task	NOUN
admet-2043	293	12	was	be	AUX
admet-2043	293	13	seen	see	VERB
admet-2043	293	14	on	on	ADP
admet-2043	293	15	the	the	DET
admet-2043	293	16	day	day	NOUN
admet-2043	293	17	of	of	ADP
admet-2043	293	18	fus	fus	PROPN
admet-2043	293	19	and	and	CCONJ
admet-2043	293	20	microbubbles	microbubble	VERB
admet-2043	293	21	application	application	NOUN
admet-2043	293	22	in	in	ADP
admet-2043	293	23	a	a	DET
admet-2043	293	24	neurotoxicity	neurotoxicity	NOUN
admet-2043	293	25	test	test	NOUN
admet-2043	293	26	using	use	VERB
admet-2043	293	27	quantitative	quantitative	ADJ
admet-2043	293	28	cognitive	cognitive	ADJ
admet-2043	293	29	assessment	assessment	NOUN
admet-2043	293	30	of	of	ADP
admet-2043	293	31	visual	visual	ADJ
admet-2043	293	32	,	,	PUNCT
admet-2043	293	33	cognitive	cognitive	ADJ
admet-2043	293	34	,	,	PUNCT
admet-2043	293	35	motivational	motivational	NOUN
admet-2043	293	36	,	,	PUNCT
admet-2043	293	37	and	and	CCONJ
admet-2043	293	38	motor	motor	NOUN
admet-2043	293	39	function	function	NOUN
admet-2043	293	40	.	.	PUNCT
admet-2043	294	1	fortunately	fortunately	ADV
admet-2043	294	2	,	,	PUNCT
admet-2043	294	3	the	the	DET
admet-2043	294	4	reaction	reaction	NOUN
admet-2043	294	5	time	time	NOUN
admet-2043	294	6	reverted	revert	VERB
admet-2043	294	7	to	to	ADP
admet-2043	294	8	normal	normal	ADJ
admet-2043	294	9	after	after	ADP
admet-2043	294	10	4	4	NUM
admet-2043	294	11	-	-	SYM
admet-2043	294	12	5	5	NUM
admet-2043	294	13	days	day	NOUN
admet-2043	294	14	of	of	ADP
admet-2043	294	15	the	the	DET
admet-2043	294	16	surgery	surgery	NOUN
admet-2043	294	17	,	,	PUNCT
admet-2043	294	18	proving	prove	VERB
admet-2043	294	19	the	the	DET
admet-2043	294	20	method	method	NOUN
admet-2043	294	21	's	's	PART
admet-2043	294	22	safety	safety	NOUN
admet-2043	294	23	[	[	X
admet-2043	294	24	87	87	NUM
admet-2043	294	25	]	]	PUNCT
admet-2043	294	26	.	.	PUNCT
admet-2043	295	1	the	the	DET
admet-2043	295	2	utilisation	utilisation	NOUN
admet-2043	295	3	of	of	ADP
admet-2043	295	4	focused	focus	VERB
admet-2043	295	5	ultrasound	ultrasound	NOUN
admet-2043	295	6	has	have	AUX
admet-2043	295	7	been	be	AUX
admet-2043	295	8	found	find	VERB
admet-2043	295	9	to	to	PART
admet-2043	295	10	yield	yield	VERB
admet-2043	295	11	numerous	numerous	ADJ
admet-2043	295	12	advantages	advantage	NOUN
admet-2043	295	13	,	,	PUNCT
admet-2043	295	14	notably	notably	ADV
admet-2043	295	15	its	its	PRON
admet-2043	295	16	non	non	ADJ
admet-2043	295	17	-	-	ADJ
admet-2043	295	18	invasive	invasive	ADJ
admet-2043	295	19	nature	nature	NOUN
admet-2043	295	20	and	and	CCONJ
admet-2043	295	21	remarkable	remarkable	ADJ
admet-2043	295	22	capacity	capacity	NOUN
admet-2043	295	23	for	for	ADP
admet-2043	295	24	precise	precise	ADJ
admet-2043	295	25	targeting	targeting	NOUN
admet-2043	295	26	.	.	PUNCT
admet-2043	296	1	these	these	DET
admet-2043	296	2	attributes	attribute	NOUN
admet-2043	296	3	enable	enable	VERB
admet-2043	296	4	the	the	DET
admet-2043	296	5	delivery	delivery	NOUN
admet-2043	296	6	of	of	ADP
admet-2043	296	7	medication	medication	NOUN
admet-2043	296	8	with	with	ADP
admet-2043	296	9	exceptional	exceptional	ADJ
admet-2043	296	10	accuracy	accuracy	NOUN
admet-2043	296	11	or	or	CCONJ
admet-2043	296	12	the	the	DET
admet-2043	296	13	manipulation	manipulation	NOUN
admet-2043	296	14	of	of	ADP
admet-2043	296	15	biological	biological	ADJ
admet-2043	296	16	processes	process	NOUN
admet-2043	296	17	,	,	PUNCT
admet-2043	296	18	all	all	PRON
admet-2043	296	19	while	while	SCONJ
admet-2043	296	20	minimising	minimise	VERB
admet-2043	296	21	the	the	DET
admet-2043	296	22	potential	potential	ADJ
admet-2043	296	23	harm	harm	NOUN
admet-2043	296	24	inflicted	inflict	VERB
admet-2043	296	25	upon	upon	SCONJ
admet-2043	296	26	adjacent	adjacent	ADJ
admet-2043	296	27	tissues	tissue	NOUN
admet-2043	296	28	.	.	PUNCT
admet-2043	297	1	the	the	DET
admet-2043	297	2	utilisation	utilisation	NOUN
admet-2043	297	3	of	of	ADP
admet-2043	297	4	this	this	DET
admet-2043	297	5	technology	technology	NOUN
admet-2043	297	6	spans	span	VERB
admet-2043	297	7	various	various	ADJ
admet-2043	297	8	domains	domain	NOUN
admet-2043	297	9	,	,	PUNCT
admet-2043	297	10	encompassing	encompass	VERB
admet-2043	297	11	imaging	imaging	NOUN
admet-2043	297	12	,	,	PUNCT
admet-2043	297	13	tumour	tumour	NOUN
admet-2043	297	14	ablation	ablation	NOUN
admet-2043	297	15	,	,	PUNCT
admet-2043	297	16	neuromodulation	neuromodulation	NOUN
admet-2043	297	17	,	,	PUNCT
admet-2043	297	18	targeted	target	VERB
admet-2043	297	19	gene	gene	NOUN
admet-2043	297	20	therapy	therapy	NOUN
admet-2043	297	21	,	,	PUNCT
admet-2043	297	22	and	and	CCONJ
admet-2043	297	23	the	the	DET
admet-2043	297	24	promising	promising	ADJ
admet-2043	297	25	prospect	prospect	NOUN
admet-2043	297	26	of	of	ADP
admet-2043	297	27	augmenting	augment	VERB
admet-2043	297	28	drug	drug	NOUN
admet-2043	297	29	administration	administration	NOUN
admet-2043	297	30	to	to	ADP
admet-2043	297	31	the	the	DET
admet-2043	297	32	cerebral	cerebral	ADJ
admet-2043	297	33	region	region	NOUN
admet-2043	297	34	.	.	PUNCT
admet-2043	298	1	the	the	DET
admet-2043	298	2	utilisation	utilisation	NOUN
admet-2043	298	3	of	of	ADP
admet-2043	298	4	this	this	DET
admet-2043	298	5	particular	particular	ADJ
admet-2043	298	6	technique	technique	NOUN
admet-2043	298	7	,	,	PUNCT
admet-2043	298	8	while	while	SCONJ
admet-2043	298	9	undoubtedly	undoubtedly	ADV
admet-2043	298	10	advantageous	advantageous	ADJ
admet-2043	298	11	,	,	PUNCT
admet-2043	298	12	is	be	AUX
admet-2043	298	13	not	not	PART
admet-2043	298	14	without	without	ADP
admet-2043	298	15	its	its	PRON
admet-2043	298	16	constraints	constraint	NOUN
admet-2043	298	17	.	.	PUNCT
admet-2043	299	1	these	these	DET
admet-2043	299	2	limitations	limitation	NOUN
admet-2043	299	3	primarily	primarily	ADV
admet-2043	299	4	manifest	manifest	ADJ
admet-2043	299	5	in	in	ADP
admet-2043	299	6	the	the	DET
admet-2043	299	7	form	form	NOUN
admet-2043	299	8	of	of	ADP
admet-2043	299	9	restricted	restricted	ADJ
admet-2043	299	10	penetration	penetration	NOUN
admet-2043	299	11	depth	depth	NOUN
admet-2043	299	12	and	and	CCONJ
admet-2043	299	13	the	the	DET
admet-2043	299	14	potential	potential	NOUN
admet-2043	299	15	for	for	ADP
admet-2043	299	16	unintended	unintended	ADJ
admet-2043	299	17	consequences	consequence	NOUN
admet-2043	299	18	in	in	ADP
admet-2043	299	19	non	non	ADJ
admet-2043	299	20	-	-	ADJ
admet-2043	299	21	target	target	ADJ
admet-2043	299	22	areas	area	NOUN
admet-2043	299	23	.	.	PUNCT
admet-2043	300	1	consequently	consequently	ADV
admet-2043	300	2	,	,	PUNCT
admet-2043	300	3	meticulous	meticulous	ADJ
admet-2043	300	4	strategizing	strategizing	NOUN
admet-2043	300	5	and	and	CCONJ
admet-2043	300	6	vigilant	vigilant	ADJ
admet-2043	300	7	oversight	oversight	NOUN
admet-2043	300	8	are	be	AUX
admet-2043	300	9	imperative	imperative	ADJ
admet-2043	300	10	to	to	PART
admet-2043	300	11	ensure	ensure	VERB
admet-2043	300	12	optimal	optimal	ADJ
admet-2043	300	13	outcomes	outcome	NOUN
admet-2043	300	14	.	.	PUNCT
admet-2043	301	1	the	the	DET
admet-2043	301	2	potential	potential	ADJ
admet-2043	301	3	hazards	hazard	NOUN
admet-2043	301	4	associated	associate	VERB
admet-2043	301	5	with	with	ADP
admet-2043	301	6	tissue	tissue	NOUN
admet-2043	301	7	injury	injury	NOUN
admet-2043	301	8	and	and	CCONJ
admet-2043	301	9	adverse	adverse	ADJ
admet-2043	301	10	events	event	NOUN
admet-2043	301	11	are	be	AUX
admet-2043	301	12	key	key	ADJ
admet-2043	301	13	factors	factor	NOUN
admet-2043	301	14	to	to	PART
admet-2043	301	15	be	be	AUX
admet-2043	301	16	considered	consider	VERB
admet-2043	301	17	when	when	SCONJ
admet-2043	301	18	considering	consider	VERB
admet-2043	301	19	safety	safety	NOUN
admet-2043	301	20	measures	measure	NOUN
admet-2043	301	21	.	.	PUNCT
admet-2043	302	1	it	it	PRON
admet-2043	302	2	is	be	AUX
admet-2043	302	3	imperative	imperative	ADJ
admet-2043	302	4	to	to	PART
admet-2043	302	5	implement	implement	VERB
admet-2043	302	6	stringent	stringent	ADJ
admet-2043	302	7	safety	safety	NOUN
admet-2043	302	8	protocols	protocol	NOUN
admet-2043	302	9	and	and	CCONJ
admet-2043	302	10	exercise	exercise	VERB
admet-2043	302	11	careful	careful	ADJ
admet-2043	302	12	patient	patient	ADJ
admet-2043	302	13	selection	selection	NOUN
admet-2043	302	14	in	in	ADP
admet-2043	302	15	order	order	NOUN
admet-2043	302	16	to	to	PART
admet-2043	302	17	mitigate	mitigate	VERB
admet-2043	302	18	these	these	DET
admet-2043	302	19	risks	risk	NOUN
admet-2043	302	20	.	.	PUNCT
admet-2043	303	1	in	in	ADP
admet-2043	303	2	summary	summary	NOUN
admet-2043	303	3	,	,	PUNCT
admet-2043	303	4	in	in	ADP
admet-2043	303	5	the	the	DET
admet-2043	303	6	first	first	ADJ
admet-2043	303	7	approach	approach	NOUN
admet-2043	303	8	,	,	PUNCT
admet-2043	303	9	they	they	PRON
admet-2043	303	10	highlight	highlight	VERB
admet-2043	303	11	chemicals	chemical	NOUN
admet-2043	303	12	like	like	ADP
admet-2043	303	13	borneol	borneol	NOUN
admet-2043	303	14	and	and	CCONJ
admet-2043	303	15	alkylglycerols	alkylglycerol	NOUN
admet-2043	303	16	that	that	PRON
admet-2043	303	17	can	can	AUX
admet-2043	303	18	enhance	enhance	VERB
admet-2043	303	19	bbb	bbb	PROPN
admet-2043	303	20	permeability	permeability	NOUN
admet-2043	303	21	,	,	PUNCT
admet-2043	303	22	potentially	potentially	ADV
admet-2043	303	23	revolutionizing	revolutionize	VERB
admet-2043	303	24	drug	drug	NOUN
admet-2043	303	25	delivery	delivery	NOUN
admet-2043	303	26	to	to	ADP
admet-2043	303	27	the	the	DET
admet-2043	303	28	brain	brain	NOUN
admet-2043	303	29	.	.	PUNCT
admet-2043	304	1	however	however	ADV
admet-2043	304	2	,	,	PUNCT
admet-2043	304	3	they	they	PRON
admet-2043	304	4	emphasize	emphasize	VERB
admet-2043	304	5	the	the	DET
admet-2043	304	6	need	need	NOUN
admet-2043	304	7	to	to	PART
admet-2043	304	8	carefully	carefully	ADV
admet-2043	304	9	evaluate	evaluate	VERB
admet-2043	304	10	these	these	DET
admet-2043	304	11	chemicals	chemical	NOUN
admet-2043	304	12	due	due	ADP
admet-2043	304	13	to	to	ADP
admet-2043	304	14	their	their	PRON
admet-2043	304	15	potential	potential	ADJ
admet-2043	304	16	toxicity	toxicity	NOUN
admet-2043	304	17	and	and	CCONJ
admet-2043	304	18	lack	lack	NOUN
admet-2043	304	19	of	of	ADP
admet-2043	304	20	selectivity	selectivity	NOUN
admet-2043	304	21	.	.	PUNCT
admet-2043	305	1	the	the	DET
admet-2043	305	2	second	second	ADJ
admet-2043	305	3	approach	approach	NOUN
admet-2043	305	4	involves	involve	VERB
admet-2043	305	5	modifying	modify	VERB
admet-2043	305	6	tight	tight	ADJ
admet-2043	305	7	junctions	junction	NOUN
admet-2043	305	8	using	use	VERB
admet-2043	305	9	adenosine	adenosine	ADJ
admet-2043	305	10	receptor	receptor	NOUN
admet-2043	305	11	agonists	agonist	NOUN
admet-2043	305	12	,	,	PUNCT
admet-2043	305	13	showcasing	showcase	VERB
admet-2043	305	14	the	the	DET
admet-2043	305	15	potential	potential	NOUN
admet-2043	305	16	to	to	PART
admet-2043	305	17	selectively	selectively	ADV
admet-2043	305	18	enhance	enhance	VERB
admet-2043	305	19	bbb	bbb	NOUN
admet-2043	305	20	permeability	permeability	NOUN
admet-2043	305	21	for	for	ADP
admet-2043	305	22	precise	precise	ADJ
admet-2043	305	23	drug	drug	NOUN
admet-2043	305	24	delivery	delivery	NOUN
admet-2043	305	25	.	.	PUNCT
admet-2043	306	1	lastly	lastly	ADV
admet-2043	306	2	,	,	PUNCT
admet-2043	306	3	the	the	DET
admet-2043	306	4	author	author	NOUN
admet-2043	306	5	underscores	underscore	VERB
admet-2043	306	6	the	the	DET
admet-2043	306	7	promising	promising	ADJ
admet-2043	306	8	role	role	NOUN
admet-2043	306	9	of	of	ADP
admet-2043	306	10	focused	focused	ADJ
admet-2043	306	11	ultrasound	ultrasound	NOUN
admet-2043	306	12	in	in	ADP
admet-2043	306	13	facilitating	facilitate	VERB
admet-2043	306	14	drug	drug	NOUN
admet-2043	306	15	transport	transport	NOUN
admet-2043	306	16	through	through	ADP
admet-2043	306	17	the	the	DET
admet-2043	306	18	bbb	bbb	PROPN
admet-2043	306	19	.	.	PUNCT
admet-2043	307	1	they	they	PRON
admet-2043	307	2	emphasize	emphasize	VERB
admet-2043	307	3	its	its	PRON
admet-2043	307	4	non	non	ADJ
admet-2043	307	5	-	-	ADJ
admet-2043	307	6	invasive	invasive	ADJ
admet-2043	307	7	nature	nature	NOUN
admet-2043	307	8	and	and	CCONJ
admet-2043	307	9	precise	precise	ADJ
admet-2043	307	10	targeting	targeting	NOUN
admet-2043	307	11	while	while	SCONJ
admet-2043	307	12	cautioning	caution	VERB
admet-2043	307	13	about	about	ADP
admet-2043	307	14	potential	potential	ADJ
admet-2043	307	15	risks	risk	NOUN
admet-2043	307	16	and	and	CCONJ
admet-2043	307	17	the	the	DET
admet-2043	307	18	need	need	NOUN
admet-2043	307	19	for	for	ADP
admet-2043	307	20	vigilant	vigilant	ADJ
admet-2043	307	21	safety	safety	NOUN
admet-2043	307	22	measures	measure	NOUN
admet-2043	307	23	.	.	PUNCT
admet-2043	308	1	overall	overall	ADV
admet-2043	308	2	,	,	PUNCT
admet-2043	308	3	the	the	DET
admet-2043	308	4	author	author	NOUN
admet-2043	308	5	's	's	PART
admet-2043	308	6	perspective	perspective	NOUN
admet-2043	308	7	centres	centre	NOUN
admet-2043	308	8	on	on	ADP
admet-2043	308	9	advancing	advance	VERB
admet-2043	308	10	drug	drug	NOUN
admet-2043	308	11	delivery	delivery	NOUN
admet-2043	308	12	strategies	strategy	NOUN
admet-2043	308	13	to	to	ADP
admet-2043	308	14	the	the	DET
admet-2043	308	15	brain	brain	NOUN
admet-2043	308	16	,	,	PUNCT
admet-2043	308	17	aiming	aim	VERB
admet-2043	308	18	for	for	ADP
admet-2043	308	19	both	both	DET
admet-2043	308	20	efficacy	efficacy	NOUN
admet-2043	308	21	and	and	CCONJ
admet-2043	308	22	safety	safety	NOUN
admet-2043	308	23	in	in	ADP
admet-2043	308	24	medical	medical	ADJ
admet-2043	308	25	applications	application	NOUN
admet-2043	308	26	.	.	PUNCT
admet-2043	309	1	intranasal	intranasal	ADJ
admet-2043	309	2	delivery	delivery	NOUN
admet-2043	309	3	to	to	PART
admet-2043	309	4	bypass	bypass	VERB
admet-2043	309	5	the	the	DET
admet-2043	309	6	bbb	bbb	PROPN
admet-2043	309	7	unmodified	unmodified	PROPN
admet-2043	309	8	nps	nps	PROPN
admet-2043	309	9	in	in	ADP
admet-2043	309	10	their	their	PRON
admet-2043	309	11	unaltered	unaltered	ADJ
admet-2043	309	12	state	state	NOUN
admet-2043	309	13	,	,	PUNCT
admet-2043	309	14	nanoparticles	nanoparticle	NOUN
admet-2043	309	15	present	present	VERB
admet-2043	309	16	a	a	DET
admet-2043	309	17	viable	viable	ADJ
admet-2043	309	18	alternative	alternative	NOUN
admet-2043	309	19	for	for	ADP
admet-2043	309	20	circumventing	circumvent	VERB
admet-2043	309	21	the	the	DET
admet-2043	309	22	bbb	bbb	NOUN
admet-2043	309	23	.	.	PUNCT
admet-2043	310	1	the	the	DET
admet-2043	310	2	enhancement	enhancement	NOUN
admet-2043	310	3	of	of	ADP
admet-2043	310	4	medication	medication	NOUN
admet-2043	310	5	administration	administration	NOUN
admet-2043	310	6	is	be	AUX
admet-2043	310	7	achieved	achieve	VERB
admet-2043	310	8	through	through	ADP
admet-2043	310	9	the	the	DET
admet-2043	310	10	inhibition	inhibition	NOUN
admet-2043	310	11	of	of	ADP
admet-2043	310	12	enzymatic	enzymatic	ADJ
admet-2043	310	13	degradation	degradation	NOUN
admet-2043	310	14	induced	induce	VERB
admet-2043	310	15	by	by	ADP
admet-2043	310	16	nasal	nasal	PROPN
admet-2043	310	17	enzymes	enzyme	NOUN
admet-2043	310	18	,	,	PUNCT
admet-2043	310	19	the	the	DET
admet-2043	310	20	mitigation	mitigation	NOUN
admet-2043	310	21	of	of	ADP
admet-2043	310	22	ciliotoxicity	ciliotoxicity	NOUN
admet-2043	310	23	,	,	PUNCT
admet-2043	310	24	and	and	CCONJ
admet-2043	310	25	the	the	DET
admet-2043	310	26	demonstrated	demonstrate	VERB
admet-2043	310	27	superiority	superiority	NOUN
admet-2043	310	28	in	in	ADP
admet-2043	310	29	drug	drug	NOUN
admet-2043	310	30	delivery	delivery	NOUN
admet-2043	310	31	efficacy	efficacy	NOUN
admet-2043	310	32	compared	compare	VERB
admet-2043	310	33	to	to	ADP
admet-2043	310	34	conventional	conventional	ADJ
admet-2043	310	35	solutions	solution	NOUN
admet-2043	310	36	.	.	PUNCT
admet-2043	311	1	several	several	ADJ
admet-2043	311	2	papers	paper	NOUN
admet-2043	311	3	supporting	support	VERB
admet-2043	311	4	this	this	DET
admet-2043	311	5	claim	claim	NOUN
admet-2043	311	6	include	include	VERB
admet-2043	311	7	jiang	jiang	PROPN
admet-2043	311	8	et	et	PROPN
admet-2043	311	9	al	al	PROPN
admet-2043	311	10	.	.	PUNCT
admet-2043	312	1	[	[	X
admet-2043	312	2	88	88	NUM
admet-2043	312	3	]	]	X
admet-2043	312	4	nimodipine	nimodipine	NOUN
admet-2043	312	5	encapsulated	encapsulate	VERB
admet-2043	312	6	microemulsions	microemulsion	NOUN
admet-2043	312	7	and	and	CCONJ
admet-2043	312	8	zhang	zhang	PROPN
admet-2043	312	9	et	et	PROPN
admet-2043	312	10	al	al	PROPN
admet-2043	312	11	.	.	PUNCT
admet-2043	313	1	[	[	X
admet-2043	313	2	89	89	NUM
admet-2043	313	3	]	]	X
admet-2043	313	4	h	h	NOUN
admet-2043	313	5	102	102	NUM
admet-2043	313	6	peptide	peptide	NOUN
admet-2043	313	7	-	-	PUNCT
admet-2043	313	8	loaded	load	VERB
admet-2043	313	9	nps	nps	PROPN
admet-2043	313	10	.	.	PUNCT
admet-2043	314	1	jiang	jiang	PROPN
admet-2043	314	2	et	et	PROPN
admet-2043	314	3	al	al	PROPN
admet-2043	314	4	.	.	PUNCT
admet-2043	315	1	[	[	X
admet-2043	315	2	88	88	NUM
admet-2043	315	3	]	]	PUNCT
admet-2043	315	4	found	find	VERB
admet-2043	315	5	that	that	SCONJ
admet-2043	315	6	a	a	DET
admet-2043	315	7	second	second	ADJ
admet-2043	315	8	-	-	PUNCT
admet-2043	315	9	generation	generation	NOUN
admet-2043	315	10	1,4	1,4	NUM
admet-2043	315	11	-	-	PUNCT
admet-2043	315	12	dihydropyridine	dihydropyridine	ADJ
admet-2043	315	13	calcium	calcium	NOUN
admet-2043	315	14	channel	channel	NOUN
admet-2043	315	15	blocker	blocker	NOUN
admet-2043	315	16	,	,	PUNCT
admet-2043	315	17	nimodipine	nimodipine	ADJ
admet-2043	315	18	encapsulated	encapsulate	VERB
admet-2043	315	19	microemulsions	microemulsion	NOUN
admet-2043	315	20	,	,	PUNCT
admet-2043	315	21	had	have	VERB
admet-2043	315	22	a	a	DET
admet-2043	315	23	13.8	13.8	NUM
admet-2043	315	24	-	-	NOUN
admet-2043	315	25	fold	fold	ADJ
admet-2043	315	26	and	and	CCONJ
admet-2043	315	27	159	159	NUM
admet-2043	315	28	-	-	ADJ
admet-2043	315	29	fold	fold	VERB
admet-2043	315	30	greater	great	ADJ
admet-2043	315	31	area	area	NOUN
admet-2043	315	32	under	under	ADP
admet-2043	315	33	the	the	DET
admet-2043	315	34	curve	curve	NOUN
admet-2043	315	35	in	in	ADP
admet-2043	315	36	the	the	DET
admet-2043	315	37	brain	brain	NOUN
admet-2043	315	38	cerebrum	cerebrum	NOUN
admet-2043	315	39	and	and	CCONJ
admet-2043	315	40	csf	csf	ADJ
admet-2043	315	41	when	when	SCONJ
admet-2043	315	42	compared	compare	VERB
admet-2043	315	43	to	to	ADP
admet-2043	315	44	iv	iv	NUM
admet-2043	315	45	treatment	treatment	NOUN
admet-2043	315	46	.	.	PUNCT
admet-2043	316	1	furthermore	furthermore	ADV
admet-2043	316	2	,	,	PUNCT
admet-2043	316	3	it	it	PRON
admet-2043	316	4	exhibited	exhibit	VERB
admet-2043	316	5	no	no	DET
admet-2043	316	6	cilia	cilia	NOUN
admet-2043	316	7	-	-	PUNCT
admet-2043	316	8	related	relate	VERB
admet-2043	316	9	toxicity	toxicity	NOUN
admet-2043	316	10	[	[	X
admet-2043	316	11	90	90	NUM
admet-2043	316	12	]	]	PUNCT
admet-2043	316	13	.	.	PUNCT
admet-2043	317	1	similarly	similarly	ADV
admet-2043	317	2	,	,	PUNCT
admet-2043	317	3	zhang	zhang	PROPN
admet-2043	317	4	et	et	PROPN
admet-2043	317	5	al	al	PROPN
admet-2043	317	6	.	.	PUNCT
admet-2043	318	1	[	[	X
admet-2043	318	2	89	89	NUM
admet-2043	318	3	]	]	PUNCT
admet-2043	318	4	h102	h102	NUM
admet-2043	318	5	peptide	peptide	NOUN
admet-2043	318	6	-	-	PUNCT
admet-2043	318	7	loaded	load	VERB
admet-2043	318	8	np	np	NOUN
admet-2043	318	9	formulation	formulation	NOUN
admet-2043	318	10	showed	show	VERB
admet-2043	318	11	1.6	1.6	NUM
admet-2043	318	12	to	to	PART
admet-2043	318	13	2.9	2.9	NUM
admet-2043	318	14	fold	fold	VERB
admet-2043	318	15	greater	great	ADJ
admet-2043	318	16	concentration	concentration	NOUN
admet-2043	318	17	than	than	ADP
admet-2043	318	18	h102	h102	NUM
admet-2043	318	19	peptide	peptide	NOUN
admet-2043	318	20	solution	solution	NOUN
admet-2043	318	21	[	[	X
admet-2043	318	22	91	91	NUM
admet-2043	318	23	]	]	PUNCT
admet-2043	318	24	.	.	PUNCT
admet-2043	319	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	319	2	m.	m.	NOUN
admet-2043	319	3	kulkarni	kulkarni	PROPN
admet-2043	319	4	et	et	PROPN
admet-2043	319	5	al	al	PROPN
admet-2043	319	6	.	.	PROPN
admet-2043	319	7	admet	admet	PROPN
admet-2043	319	8	&	&	CCONJ
admet-2043	319	9	dmpk	dmpk	PROPN
admet-2043	319	10	12(1	12(1	PROPN
admet-2043	319	11	)	)	PUNCT
admet-2043	319	12	(	(	PUNCT
admet-2043	319	13	2024	2024	NUM
admet-2043	319	14	)	)	PUNCT
admet-2043	319	15	63	63	NUM
admet-2043	319	16	-	-	SYM
admet-2043	319	17	105	105	NUM
admet-2043	319	18	76	76	NUM
admet-2043	319	19	the	the	DET
admet-2043	319	20	incorporation	incorporation	NOUN
admet-2043	319	21	of	of	ADP
admet-2043	319	22	a	a	DET
admet-2043	319	23	unique	unique	ADJ
admet-2043	319	24	ligand	ligand	NOUN
admet-2043	319	25	into	into	ADP
admet-2043	319	26	nanoparticles	nanoparticle	NOUN
admet-2043	319	27	has	have	AUX
admet-2043	319	28	been	be	AUX
admet-2043	319	29	observed	observe	VERB
admet-2043	319	30	to	to	PART
admet-2043	319	31	enhance	enhance	VERB
admet-2043	319	32	their	their	PRON
admet-2043	319	33	targeting	target	VERB
admet-2043	319	34	capabilities	capability	NOUN
admet-2043	319	35	.	.	PUNCT
admet-2043	320	1	enhancements	enhancement	NOUN
admet-2043	320	2	in	in	ADP
admet-2043	320	3	drug	drug	NOUN
admet-2043	320	4	penetration	penetration	NOUN
admet-2043	320	5	through	through	ADP
admet-2043	320	6	the	the	DET
admet-2043	320	7	nasal	nasal	ADJ
admet-2043	320	8	mucosa	mucosa	NOUN
admet-2043	320	9	have	have	AUX
admet-2043	320	10	been	be	AUX
admet-2043	320	11	observed	observe	VERB
admet-2043	320	12	,	,	PUNCT
admet-2043	320	13	facilitating	facilitate	VERB
admet-2043	320	14	the	the	DET
admet-2043	320	15	transportation	transportation	NOUN
admet-2043	320	16	of	of	ADP
admet-2043	320	17	medications	medication	NOUN
admet-2043	320	18	into	into	ADP
admet-2043	320	19	the	the	DET
admet-2043	320	20	brain	brain	NOUN
admet-2043	320	21	and	and	CCONJ
admet-2043	320	22	enabling	enable	VERB
admet-2043	320	23	more	more	ADV
admet-2043	320	24	efficient	efficient	ADJ
admet-2043	320	25	delivery	delivery	NOUN
admet-2043	320	26	of	of	ADP
admet-2043	320	27	therapeutic	therapeutic	ADJ
admet-2043	320	28	agents	agent	NOUN
admet-2043	320	29	.	.	PUNCT
admet-2043	321	1	moreover	moreover	ADV
admet-2043	321	2	,	,	PUNCT
admet-2043	321	3	it	it	PRON
admet-2043	321	4	has	have	AUX
admet-2043	321	5	been	be	AUX
admet-2043	321	6	observed	observe	VERB
admet-2043	321	7	that	that	SCONJ
admet-2043	321	8	nps	nps	PROPN
admet-2043	321	9	can	can	AUX
admet-2043	321	10	be	be	AUX
admet-2043	321	11	meticulously	meticulously	ADV
admet-2043	321	12	engineered	engineer	VERB
admet-2043	321	13	to	to	PART
admet-2043	321	14	selectively	selectively	ADV
admet-2043	321	15	target	target	VERB
admet-2043	321	16	distinct	distinct	ADJ
admet-2043	321	17	neuronal	neuronal	ADJ
admet-2043	321	18	cells	cell	NOUN
admet-2043	321	19	or	or	CCONJ
admet-2043	321	20	regions	region	NOUN
admet-2043	321	21	within	within	ADP
admet-2043	321	22	the	the	DET
admet-2043	321	23	brain	brain	NOUN
admet-2043	321	24	,	,	PUNCT
admet-2043	321	25	thereby	thereby	ADV
admet-2043	321	26	facilitating	facilitate	VERB
admet-2043	321	27	the	the	DET
admet-2043	321	28	precise	precise	ADJ
admet-2043	321	29	administration	administration	NOUN
admet-2043	321	30	of	of	ADP
admet-2043	321	31	pharmaceutical	pharmaceutical	ADJ
admet-2043	321	32	agents	agent	NOUN
admet-2043	321	33	.	.	PUNCT
admet-2043	322	1	the	the	DET
admet-2043	322	2	intranasal	intranasal	ADJ
admet-2043	322	3	delivery	delivery	NOUN
admet-2043	322	4	route	route	NOUN
admet-2043	322	5	is	be	AUX
admet-2043	322	6	considered	consider	VERB
admet-2043	322	7	non	non	ADJ
admet-2043	322	8	-	-	ADJ
admet-2043	322	9	invasive	invasive	ADJ
admet-2043	322	10	,	,	PUNCT
admet-2043	322	11	as	as	SCONJ
admet-2043	322	12	it	it	PRON
admet-2043	322	13	does	do	AUX
admet-2043	322	14	not	not	PART
admet-2043	322	15	necessitate	necessitate	VERB
admet-2043	322	16	injections	injection	NOUN
admet-2043	322	17	or	or	CCONJ
admet-2043	322	18	surgical	surgical	ADJ
admet-2043	322	19	interventions	intervention	NOUN
admet-2043	322	20	.	.	PUNCT
admet-2043	323	1	moreover	moreover	ADV
admet-2043	323	2	,	,	PUNCT
admet-2043	323	3	it	it	PRON
admet-2043	323	4	has	have	AUX
admet-2043	323	5	been	be	AUX
admet-2043	323	6	observed	observe	VERB
admet-2043	323	7	that	that	SCONJ
admet-2043	323	8	the	the	DET
admet-2043	323	9	utilisation	utilisation	NOUN
admet-2043	323	10	of	of	ADP
admet-2043	323	11	nps	nps	PROPN
admet-2043	323	12	has	have	VERB
admet-2043	323	13	the	the	DET
admet-2043	323	14	potential	potential	NOUN
admet-2043	323	15	to	to	PART
admet-2043	323	16	significantly	significantly	ADV
admet-2043	323	17	enhance	enhance	VERB
admet-2043	323	18	the	the	DET
admet-2043	323	19	bioavailability	bioavailability	NOUN
admet-2043	323	20	of	of	ADP
admet-2043	323	21	medications	medication	NOUN
admet-2043	323	22	.	.	PUNCT
admet-2043	324	1	this	this	PRON
admet-2043	324	2	is	be	AUX
admet-2043	324	3	primarily	primarily	ADV
admet-2043	324	4	attributed	attribute	VERB
admet-2043	324	5	to	to	ADP
admet-2043	324	6	the	the	DET
admet-2043	324	7	ability	ability	NOUN
admet-2043	324	8	of	of	ADP
admet-2043	324	9	nps	nps	PROPN
admet-2043	324	10	to	to	PART
admet-2043	324	11	effectively	effectively	ADV
admet-2043	324	12	prevent	prevent	VERB
admet-2043	324	13	medication	medication	NOUN
admet-2043	324	14	degradation	degradation	NOUN
admet-2043	324	15	and	and	CCONJ
admet-2043	324	16	improve	improve	VERB
admet-2043	324	17	drug	drug	NOUN
admet-2043	324	18	stability	stability	NOUN
admet-2043	324	19	.	.	PUNCT
admet-2043	325	1	nevertheless	nevertheless	ADV
admet-2043	325	2	,	,	PUNCT
admet-2043	325	3	it	it	PRON
admet-2043	325	4	is	be	AUX
admet-2043	325	5	imperative	imperative	ADJ
admet-2043	325	6	to	to	PART
admet-2043	325	7	acknowledge	acknowledge	VERB
admet-2043	325	8	the	the	DET
admet-2043	325	9	existence	existence	NOUN
admet-2043	325	10	of	of	ADP
admet-2043	325	11	various	various	ADJ
admet-2043	325	12	drawbacks	drawback	NOUN
admet-2043	325	13	associated	associate	VERB
admet-2043	325	14	with	with	ADP
admet-2043	325	15	the	the	DET
admet-2043	325	16	utilisation	utilisation	NOUN
admet-2043	325	17	of	of	ADP
admet-2043	325	18	unmodified	unmodified	ADJ
admet-2043	325	19	np	np	NOUN
admet-2043	325	20	systems	system	NOUN
admet-2043	325	21	.	.	PUNCT
admet-2043	326	1	these	these	DET
admet-2043	326	2	limitations	limitation	NOUN
admet-2043	326	3	primarily	primarily	ADV
admet-2043	326	4	revolve	revolve	VERB
admet-2043	326	5	around	around	ADP
admet-2043	326	6	their	their	PRON
admet-2043	326	7	inherent	inherent	ADJ
admet-2043	326	8	incapacity	incapacity	NOUN
admet-2043	326	9	to	to	PART
admet-2043	326	10	effectively	effectively	ADV
admet-2043	326	11	encapsulate	encapsulate	VERB
admet-2043	326	12	a	a	DET
admet-2043	326	13	sufficient	sufficient	ADJ
admet-2043	326	14	quantity	quantity	NOUN
admet-2043	326	15	of	of	ADP
admet-2043	326	16	therapeutic	therapeutic	ADJ
admet-2043	326	17	molecules	molecule	NOUN
admet-2043	326	18	,	,	PUNCT
admet-2043	326	19	thereby	thereby	ADV
admet-2043	326	20	compromising	compromise	VERB
admet-2043	326	21	their	their	PRON
admet-2043	326	22	therapeutic	therapeutic	ADJ
admet-2043	326	23	potential	potential	NOUN
admet-2043	326	24	.	.	PUNCT
admet-2043	327	1	additionally	additionally	ADV
admet-2043	327	2	,	,	PUNCT
admet-2043	327	3	it	it	PRON
admet-2043	327	4	is	be	AUX
admet-2043	327	5	crucial	crucial	ADJ
admet-2043	327	6	to	to	PART
admet-2043	327	7	consider	consider	VERB
admet-2043	327	8	the	the	DET
admet-2043	327	9	potential	potential	ADJ
admet-2043	327	10	toxicity	toxicity	NOUN
admet-2043	327	11	that	that	PRON
admet-2043	327	12	may	may	AUX
admet-2043	327	13	arise	arise	VERB
admet-2043	327	14	from	from	ADP
admet-2043	327	15	the	the	DET
admet-2043	327	16	substances	substance	NOUN
admet-2043	327	17	employed	employ	VERB
admet-2043	327	18	in	in	ADP
admet-2043	327	19	the	the	DET
admet-2043	327	20	formation	formation	NOUN
admet-2043	327	21	of	of	ADP
admet-2043	327	22	these	these	DET
admet-2043	327	23	unmodified	unmodified	ADJ
admet-2043	327	24	nps	nps	PROPN
admet-2043	327	25	.	.	PUNCT
admet-2043	328	1	nasal	nasal	PROPN
admet-2043	328	2	polyps	polyp	NOUN
admet-2043	328	3	exhibit	exhibit	VERB
admet-2043	328	4	rapid	rapid	ADJ
admet-2043	328	5	egress	egress	NOUN
admet-2043	328	6	from	from	ADP
admet-2043	328	7	the	the	DET
admet-2043	328	8	nasal	nasal	ADJ
admet-2043	328	9	cavity	cavity	NOUN
admet-2043	328	10	,	,	PUNCT
admet-2043	328	11	reducing	reduce	VERB
admet-2043	328	12	medication	medication	NOUN
admet-2043	328	13	exposure	exposure	NOUN
admet-2043	328	14	and	and	CCONJ
admet-2043	328	15	subsequent	subsequent	ADJ
admet-2043	328	16	therapeutic	therapeutic	ADJ
admet-2043	328	17	efficacy	efficacy	NOUN
admet-2043	328	18	.	.	PUNCT
admet-2043	329	1	the	the	DET
admet-2043	329	2	efficacy	efficacy	NOUN
admet-2043	329	3	of	of	ADP
admet-2043	329	4	unmodified	unmodified	PROPN
admet-2043	329	5	nps	nps	PROPN
admet-2043	329	6	exhibits	exhibit	VERB
admet-2043	329	7	variability	variability	NOUN
admet-2043	329	8	contingent	contingent	NOUN
admet-2043	329	9	upon	upon	SCONJ
admet-2043	329	10	factors	factor	NOUN
admet-2043	329	11	such	such	ADJ
admet-2043	329	12	as	as	ADP
admet-2043	329	13	particle	particle	NOUN
admet-2043	329	14	size	size	NOUN
admet-2043	329	15	,	,	PUNCT
admet-2043	329	16	shape	shape	NOUN
admet-2043	329	17	,	,	PUNCT
admet-2043	329	18	and	and	CCONJ
admet-2043	329	19	surface	surface	NOUN
admet-2043	329	20	charge	charge	NOUN
admet-2043	329	21	.	.	PUNCT
admet-2043	330	1	these	these	DET
admet-2043	330	2	parameters	parameter	NOUN
admet-2043	330	3	exert	exert	VERB
admet-2043	330	4	an	an	DET
admet-2043	330	5	influence	influence	NOUN
admet-2043	330	6	on	on	ADP
admet-2043	330	7	the	the	DET
admet-2043	330	8	nps	nps	PROPN
admet-2043	330	9	'	'	PART
admet-2043	330	10	ability	ability	NOUN
admet-2043	330	11	to	to	PART
admet-2043	330	12	traverse	traverse	VERB
admet-2043	330	13	the	the	DET
admet-2043	330	14	nasal	nasal	ADJ
admet-2043	330	15	epithelium	epithelium	NOUN
admet-2043	330	16	and	and	CCONJ
admet-2043	330	17	ultimately	ultimately	ADV
admet-2043	330	18	access	access	VERB
admet-2043	330	19	the	the	DET
admet-2043	330	20	brain	brain	NOUN
admet-2043	330	21	.	.	PUNCT
admet-2043	331	1	[	[	X
admet-2043	331	2	92	92	NUM
admet-2043	331	3	-	-	SYM
admet-2043	331	4	94	94	NUM
admet-2043	331	5	]	]	PUNCT
admet-2043	331	6	agglutinant	agglutinant	ADJ
admet-2043	331	7	-	-	PUNCT
admet-2043	331	8	mediated	mediate	VERB
admet-2043	331	9	transport	transport	NOUN
admet-2043	331	10	agglutinants	agglutinant	NOUN
admet-2043	331	11	can	can	AUX
admet-2043	331	12	attach	attach	VERB
admet-2043	331	13	to	to	ADP
admet-2043	331	14	saccharide	saccharide	NOUN
admet-2043	331	15	groups	group	NOUN
admet-2043	331	16	and	and	CCONJ
admet-2043	331	17	stimulate	stimulate	VERB
admet-2043	331	18	endocytosis	endocytosis	NOUN
admet-2043	331	19	,	,	PUNCT
admet-2043	331	20	which	which	PRON
admet-2043	331	21	can	can	AUX
admet-2043	331	22	be	be	AUX
admet-2043	331	23	used	use	VERB
admet-2043	331	24	to	to	PART
admet-2043	331	25	improve	improve	VERB
admet-2043	331	26	intranasal	intranasal	ADJ
admet-2043	331	27	medication	medication	NOUN
admet-2043	331	28	delivery	delivery	NOUN
admet-2043	331	29	due	due	ADP
admet-2043	331	30	to	to	ADP
admet-2043	331	31	greater	great	ADJ
admet-2043	331	32	expression	expression	NOUN
admet-2043	331	33	of	of	ADP
admet-2043	331	34	saccharide	saccharide	NOUN
admet-2043	331	35	groups	group	NOUN
admet-2043	331	36	on	on	ADP
admet-2043	331	37	olfactory	olfactory	ADJ
admet-2043	331	38	mucosa	mucosa	NOUN
admet-2043	331	39	,	,	PUNCT
admet-2043	331	40	such	such	ADJ
admet-2043	331	41	as	as	ADP
admet-2043	331	42	n	n	NOUN
admet-2043	331	43	-	-	PUNCT
admet-2043	331	44	acetylglucosamine	acetylglucosamine	NOUN
admet-2043	331	45	and	and	CCONJ
admet-2043	331	46	l	l	NOUN
admet-2043	331	47	-	-	NOUN
admet-2043	331	48	fucose	fucose	NOUN
admet-2043	332	1	[	[	X
admet-2043	332	2	95	95	NUM
admet-2043	332	3	]	]	PUNCT
admet-2043	332	4	.	.	PUNCT
admet-2043	333	1	jiang	jiang	PROPN
admet-2043	333	2	et	et	PROPN
admet-2043	333	3	al	al	PROPN
admet-2043	333	4	.	.	PUNCT
admet-2043	334	1	[	[	X
admet-2043	334	2	96	96	NUM
admet-2043	334	3	]	]	PUNCT
admet-2043	334	4	used	use	VERB
admet-2043	334	5	this	this	DET
admet-2043	334	6	approach	approach	NOUN
admet-2043	334	7	to	to	PART
admet-2043	334	8	transfer	transfer	VERB
admet-2043	334	9	vasoactive	vasoactive	ADJ
admet-2043	334	10	intestinal	intestinal	ADJ
admet-2043	334	11	peptides	peptide	NOUN
admet-2043	334	12	via	via	ADP
admet-2043	334	13	modified	modify	VERB
admet-2043	334	14	wheat	wheat	NOUN
admet-2043	334	15	germ	germ	NOUN
admet-2043	334	16	agglutinin	agglutinin	NOUN
admet-2043	334	17	(	(	PUNCT
admet-2043	334	18	wga	wga	PROPN
admet-2043	334	19	)	)	PUNCT
admet-2043	334	20	onto	onto	ADP
admet-2043	334	21	poly(lactic	poly(lactic	PROPN
admet-2043	334	22	-	-	PUNCT
admet-2043	334	23	co	co	NOUN
admet-2043	334	24	-	-	ADJ
admet-2043	334	25	glycolic	glycolic	ADJ
admet-2043	334	26	acid	acid	NOUN
admet-2043	334	27	)	)	PUNCT
admet-2043	334	28	(	(	PUNCT
admet-2043	334	29	plga	plga	NOUN
admet-2043	334	30	-nps	-nps	PROPN
admet-2043	334	31	)	)	PUNCT
admet-2043	334	32	(	(	PUNCT
admet-2043	334	33	wga	wga	PROPN
admet-2043	334	34	-	-	PUNCT
admet-2043	334	35	nps	nps	PROPN
admet-2043	334	36	)	)	PUNCT
admet-2043	334	37	.	.	PUNCT
admet-2043	335	1	this	this	DET
admet-2043	335	2	investigation	investigation	NOUN
admet-2043	335	3	revealed	reveal	VERB
admet-2043	335	4	that	that	SCONJ
admet-2043	335	5	intact	intact	ADJ
admet-2043	335	6	vip	vip	NOUN
admet-2043	335	7	given	give	VERB
admet-2043	335	8	to	to	ADP
admet-2043	335	9	the	the	DET
admet-2043	335	10	brain	brain	NOUN
admet-2043	335	11	had	have	VERB
admet-2043	335	12	11.48	11.48	NUM
admet-2043	335	13	%	%	NOUN
admet-2043	335	14	i	i	PROPN
admet-2043	335	15	d	d	PROPN
admet-2043	335	16	h	h	PROPN
admet-2043	335	17	/	/	SYM
admet-2043	335	18	g	g	NOUN
admet-2043	335	19	,	,	PUNCT
admet-2043	335	20	which	which	PRON
admet-2043	335	21	was	be	AUX
admet-2043	335	22	7.74	7.74	NUM
admet-2043	335	23	times	time	NOUN
admet-2043	335	24	higher	high	ADJ
admet-2043	335	25	than	than	ADP
admet-2043	335	26	the	the	DET
admet-2043	335	27	vip	vip	NOUN
admet-2043	335	28	solution	solution	NOUN
admet-2043	335	29	[	[	X
admet-2043	335	30	96	96	NUM
admet-2043	335	31	]	]	PUNCT
admet-2043	335	32	.	.	PUNCT
admet-2043	336	1	this	this	PRON
admet-2043	336	2	was	be	AUX
admet-2043	336	3	attributable	attributable	ADJ
admet-2043	336	4	to	to	ADP
admet-2043	336	5	wga	wga	PROPN
admet-2043	336	6	-	-	PUNCT
admet-2043	336	7	nps	nps	PROPN
admet-2043	336	8	'	'	PUNCT
admet-2043	336	9	greater	great	ADJ
admet-2043	336	10	affinity	affinity	NOUN
admet-2043	336	11	and	and	CCONJ
admet-2043	336	12	better	well	ADJ
admet-2043	336	13	penetration	penetration	NOUN
admet-2043	336	14	into	into	ADP
admet-2043	336	15	the	the	DET
admet-2043	336	16	olfactory	olfactory	ADJ
admet-2043	336	17	mucosa	mucosa	NOUN
admet-2043	336	18	[	[	X
admet-2043	336	19	97	97	NUM
admet-2043	336	20	]	]	PUNCT
admet-2043	336	21	.	.	PUNCT
admet-2043	337	1	similar	similar	ADJ
admet-2043	337	2	trials	trial	NOUN
admet-2043	337	3	with	with	ADP
admet-2043	337	4	different	different	ADJ
admet-2043	337	5	medicines	medicine	NOUN
admet-2043	337	6	,	,	PUNCT
admet-2043	337	7	such	such	ADJ
admet-2043	337	8	as	as	ADP
admet-2043	337	9	ulex	ulex	PROPN
admet-2043	337	10	europeus	europeus	PROPN
admet-2043	337	11	agglutinin	agglutinin	PROPN
admet-2043	337	12	i	i	PROPN
admet-2043	337	13	(	(	PUNCT
admet-2043	337	14	uea	uea	PROPN
admet-2043	337	15	i	i	PROPN
admet-2043	337	16	)	)	PUNCT
admet-2043	337	17	,	,	PUNCT
admet-2043	337	18	solanum	solanum	NOUN
admet-2043	337	19	tuberosum	tuberosum	NOUN
admet-2043	337	20	lectin	lectin	NOUN
admet-2043	337	21	,	,	PUNCT
admet-2043	337	22	and	and	CCONJ
admet-2043	337	23	odorranalectin	odorranalectin	NOUN
admet-2043	337	24	,	,	PUNCT
admet-2043	337	25	yielded	yield	VERB
admet-2043	337	26	the	the	DET
admet-2043	337	27	same	same	ADJ
admet-2043	337	28	improved	improved	ADJ
admet-2043	337	29	efficiency	efficiency	NOUN
admet-2043	337	30	in	in	ADP
admet-2043	337	31	drug	drug	NOUN
admet-2043	337	32	administration	administration	NOUN
admet-2043	337	33	[	[	X
admet-2043	337	34	98	98	NUM
admet-2043	337	35	]	]	PUNCT
admet-2043	337	36	.	.	PUNCT
admet-2043	338	1	a	a	DET
admet-2043	338	2	novel	novel	ADJ
admet-2043	338	3	tiny	tiny	ADJ
admet-2043	338	4	odorranalectin	odorranalectin	NOUN
admet-2043	338	5	-	-	PUNCT
admet-2043	338	6	containing	contain	VERB
admet-2043	338	7	cubosome	cubosome	NOUN
admet-2043	338	8	demonstrated	demonstrate	VERB
admet-2043	338	9	promising	promising	ADJ
admet-2043	338	10	results	result	NOUN
admet-2043	338	11	,	,	PUNCT
admet-2043	338	12	including	include	VERB
admet-2043	338	13	successful	successful	ADJ
admet-2043	338	14	synthesis	synthesis	NOUN
admet-2043	338	15	,	,	PUNCT
admet-2043	338	16	effective	effective	ADJ
admet-2043	338	17	brain	brain	NOUN
admet-2043	338	18	transport	transport	NOUN
admet-2043	338	19	,	,	PUNCT
admet-2043	338	20	and	and	CCONJ
admet-2043	338	21	pharmacodynamics	pharmacodynamic	NOUN
admet-2043	338	22	evaluation	evaluation	NOUN
admet-2043	338	23	in	in	ADP
admet-2043	338	24	amyloid	amyloid	NOUN
admet-2043	338	25	-	-	PUNCT
admet-2043	338	26	treated	treat	VERB
admet-2043	338	27	rats	rat	NOUN
admet-2043	338	28	after	after	ADP
admet-2043	338	29	intranasal	intranasal	ADJ
admet-2043	338	30	administration	administration	NOUN
admet-2043	338	31	[	[	X
admet-2043	338	32	99	99	NUM
admet-2043	338	33	]	]	PUNCT
admet-2043	338	34	.	.	PUNCT
admet-2043	339	1	this	this	DET
admet-2043	339	2	technique	technique	NOUN
admet-2043	339	3	has	have	VERB
admet-2043	339	4	some	some	DET
admet-2043	339	5	perks	perk	NOUN
admet-2043	339	6	,	,	PUNCT
admet-2043	339	7	including	include	VERB
admet-2043	339	8	the	the	DET
admet-2043	339	9	capacity	capacity	NOUN
admet-2043	339	10	to	to	PART
admet-2043	339	11	create	create	VERB
admet-2043	339	12	agglutinnants	agglutinnant	NOUN
admet-2043	339	13	that	that	PRON
admet-2043	339	14	particularly	particularly	ADV
admet-2043	339	15	target	target	VERB
admet-2043	339	16	receptors	receptor	NOUN
admet-2043	339	17	on	on	ADP
admet-2043	339	18	brain	brain	NOUN
admet-2043	339	19	endothelial	endothelial	ADJ
admet-2043	339	20	cells	cell	NOUN
admet-2043	339	21	,	,	PUNCT
admet-2043	339	22	allowing	allow	VERB
admet-2043	339	23	for	for	ADP
admet-2043	339	24	precise	precise	ADJ
admet-2043	339	25	transport	transport	NOUN
admet-2043	339	26	of	of	ADP
admet-2043	339	27	nps	nps	PROPN
admet-2043	339	28	to	to	ADP
admet-2043	339	29	the	the	DET
admet-2043	339	30	brain	brain	NOUN
admet-2043	339	31	.	.	PUNCT
admet-2043	340	1	however	however	ADV
admet-2043	340	2	,	,	PUNCT
admet-2043	340	3	there	there	PRON
admet-2043	340	4	are	be	VERB
admet-2043	340	5	a	a	DET
admet-2043	340	6	number	number	NOUN
admet-2043	340	7	of	of	ADP
admet-2043	340	8	disadvantages	disadvantage	NOUN
admet-2043	340	9	to	to	PART
admet-2043	340	10	consider	consider	VERB
admet-2043	340	11	.	.	PUNCT
admet-2043	341	1	agglutinants	agglutinant	NOUN
admet-2043	341	2	may	may	AUX
admet-2043	341	3	be	be	AUX
admet-2043	341	4	nonselective	nonselective	ADJ
admet-2043	341	5	for	for	ADP
admet-2043	341	6	brain	brain	NOUN
admet-2043	341	7	endothelial	endothelial	ADJ
admet-2043	341	8	cell	cell	NOUN
admet-2043	341	9	receptors	receptor	NOUN
admet-2043	341	10	,	,	PUNCT
admet-2043	341	11	resulting	result	VERB
admet-2043	341	12	in	in	ADP
admet-2043	341	13	off	off	ADP
admet-2043	341	14	-	-	PUNCT
admet-2043	341	15	target	target	NOUN
admet-2043	341	16	effects	effect	NOUN
admet-2043	341	17	or	or	CCONJ
admet-2043	341	18	inadequate	inadequate	ADJ
admet-2043	341	19	targeting	targeting	NOUN
admet-2043	341	20	.	.	PUNCT
admet-2043	342	1	agglutinants	agglutinant	NOUN
admet-2043	342	2	can	can	AUX
admet-2043	342	3	also	also	ADV
admet-2043	342	4	be	be	AUX
admet-2043	342	5	immunogenic	immunogenic	ADJ
admet-2043	342	6	or	or	CCONJ
admet-2043	342	7	toxic	toxic	ADJ
admet-2043	342	8	,	,	PUNCT
admet-2043	342	9	eliciting	elicit	VERB
admet-2043	342	10	immunological	immunological	ADJ
admet-2043	342	11	responses	response	NOUN
admet-2043	342	12	or	or	CCONJ
admet-2043	342	13	having	have	VERB
admet-2043	342	14	negative	negative	ADJ
admet-2043	342	15	effects	effect	NOUN
admet-2043	342	16	.	.	PUNCT
admet-2043	343	1	the	the	DET
admet-2043	343	2	development	development	NOUN
admet-2043	343	3	of	of	ADP
admet-2043	343	4	agglutinant	agglutinant	ADJ
admet-2043	343	5	-	-	PUNCT
admet-2043	343	6	mediated	mediate	VERB
admet-2043	343	7	transport	transport	NOUN
admet-2043	343	8	systems	system	NOUN
admet-2043	343	9	is	be	AUX
admet-2043	343	10	difficult	difficult	ADJ
admet-2043	343	11	and	and	CCONJ
admet-2043	343	12	timeconsuming	timeconsuming	ADJ
admet-2043	343	13	,	,	PUNCT
admet-2043	343	14	requiring	require	VERB
admet-2043	343	15	careful	careful	ADJ
admet-2043	343	16	agglutinant	agglutinant	NOUN
admet-2043	343	17	selection	selection	NOUN
admet-2043	343	18	and	and	CCONJ
admet-2043	343	19	conjugation	conjugation	NOUN
admet-2043	343	20	to	to	ADP
admet-2043	343	21	nps	nps	PROPN
admet-2043	343	22	[	[	X
admet-2043	343	23	100,101	100,101	NUM
admet-2043	343	24	]	]	PUNCT
admet-2043	343	25	.	.	PUNCT
admet-2043	344	1	in	in	ADP
admet-2043	344	2	essence	essence	NOUN
admet-2043	344	3	,	,	PUNCT
admet-2043	344	4	the	the	DET
admet-2043	344	5	unmodified	unmodified	PROPN
admet-2043	344	6	nps	nps	PROPN
admet-2043	344	7	demonstrate	demonstrate	VERB
admet-2043	344	8	the	the	DET
admet-2043	344	9	potential	potential	NOUN
admet-2043	344	10	to	to	PART
admet-2043	344	11	enhance	enhance	VERB
admet-2043	344	12	medication	medication	NOUN
admet-2043	344	13	administration	administration	NOUN
admet-2043	344	14	by	by	ADP
admet-2043	344	15	inhibiting	inhibit	VERB
admet-2043	344	16	enzymatic	enzymatic	ADJ
admet-2043	344	17	degradation	degradation	NOUN
admet-2043	344	18	,	,	PUNCT
admet-2043	344	19	mitigating	mitigate	VERB
admet-2043	344	20	ciliotoxicity	ciliotoxicity	NOUN
admet-2043	344	21	,	,	PUNCT
admet-2043	344	22	and	and	CCONJ
admet-2043	344	23	showcasing	showcase	VERB
admet-2043	344	24	superior	superior	ADJ
admet-2043	344	25	drug	drug	NOUN
admet-2043	344	26	delivery	delivery	NOUN
admet-2043	344	27	efficacy	efficacy	NOUN
admet-2043	344	28	compared	compare	VERB
admet-2043	344	29	to	to	ADP
admet-2043	344	30	conventional	conventional	ADJ
admet-2043	344	31	solutions	solution	NOUN
admet-2043	344	32	.	.	PUNCT
admet-2043	345	1	the	the	DET
admet-2043	345	2	incorporation	incorporation	NOUN
admet-2043	345	3	of	of	ADP
admet-2043	345	4	unique	unique	ADJ
admet-2043	345	5	ligands	ligand	NOUN
admet-2043	345	6	into	into	ADP
admet-2043	345	7	nps	nps	PROPN
admet-2043	345	8	further	far	ADV
admet-2043	345	9	enhances	enhance	VERB
admet-2043	345	10	their	their	PRON
admet-2043	345	11	targeting	target	VERB
admet-2043	345	12	capabilities	capability	NOUN
admet-2043	345	13	,	,	PUNCT
admet-2043	345	14	allowing	allow	VERB
admet-2043	345	15	for	for	ADP
admet-2043	345	16	precise	precise	ADJ
admet-2043	345	17	drug	drug	NOUN
admet-2043	345	18	penetration	penetration	NOUN
admet-2043	345	19	through	through	ADP
admet-2043	345	20	the	the	DET
admet-2043	345	21	nasal	nasal	ADJ
admet-2043	345	22	mucosa	mucosa	NOUN
admet-2043	345	23	and	and	CCONJ
admet-2043	345	24	efficient	efficient	ADJ
admet-2043	345	25	delivery	delivery	NOUN
admet-2043	345	26	of	of	ADP
admet-2043	345	27	therapeutic	therapeutic	ADJ
admet-2043	345	28	agents	agent	NOUN
admet-2043	345	29	.	.	PUNCT
admet-2043	346	1	admet	admet	PROPN
admet-2043	346	2	&	&	CCONJ
admet-2043	346	3	dmpk	dmpk	PROPN
admet-2043	346	4	12(1	12(1	PROPN
admet-2043	346	5	)	)	PUNCT
admet-2043	346	6	(	(	PUNCT
admet-2043	346	7	2024	2024	NUM
admet-2043	346	8	)	)	PUNCT
admet-2043	346	9	63	63	NUM
admet-2043	346	10	-	-	SYM
admet-2043	346	11	105	105	NUM
admet-2043	346	12	nanomaterials	nanomaterial	NOUN
admet-2043	346	13	as	as	ADP
admet-2043	346	14	drug	drug	NOUN
admet-2043	346	15	delivery	delivery	NOUN
admet-2043	346	16	agents	agent	NOUN
admet-2043	346	17	for	for	ADP
admet-2043	346	18	overcoming	overcome	VERB
admet-2043	346	19	bbb	bbb	PROPN
admet-2043	346	20	doi	doi	NOUN
admet-2043	346	21	:	:	PUNCT
admet-2043	346	22	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	346	23	77	77	NUM
admet-2043	346	24	additionally	additionally	ADV
admet-2043	346	25	,	,	PUNCT
admet-2043	346	26	agglutinants	agglutinant	NOUN
admet-2043	346	27	are	be	AUX
admet-2043	346	28	a	a	DET
admet-2043	346	29	valuable	valuable	ADJ
admet-2043	346	30	tool	tool	NOUN
admet-2043	346	31	for	for	ADP
admet-2043	346	32	improving	improve	VERB
admet-2043	346	33	intranasal	intranasal	ADJ
admet-2043	346	34	medication	medication	NOUN
admet-2043	346	35	delivery	delivery	NOUN
admet-2043	346	36	by	by	ADP
admet-2043	346	37	stimulating	stimulate	VERB
admet-2043	346	38	endocytosis	endocytosis	NOUN
admet-2043	346	39	through	through	ADP
admet-2043	346	40	attachment	attachment	NOUN
admet-2043	346	41	to	to	ADP
admet-2043	346	42	saccharide	saccharide	NOUN
admet-2043	346	43	groups	group	NOUN
admet-2043	346	44	.	.	PUNCT
admet-2043	347	1	they	they	PRON
admet-2043	347	2	offer	offer	VERB
admet-2043	347	3	the	the	DET
admet-2043	347	4	advantage	advantage	NOUN
admet-2043	347	5	of	of	ADP
admet-2043	347	6	specifically	specifically	ADV
admet-2043	347	7	targeting	target	VERB
admet-2043	347	8	receptors	receptor	NOUN
admet-2043	347	9	on	on	ADP
admet-2043	347	10	brain	brain	NOUN
admet-2043	347	11	endothelial	endothelial	ADJ
admet-2043	347	12	cells	cell	NOUN
admet-2043	347	13	,	,	PUNCT
admet-2043	347	14	facilitating	facilitate	VERB
admet-2043	347	15	the	the	DET
admet-2043	347	16	precise	precise	ADJ
admet-2043	347	17	transport	transport	NOUN
admet-2043	347	18	of	of	ADP
admet-2043	347	19	nps	nps	PROPN
admet-2043	347	20	to	to	ADP
admet-2043	347	21	the	the	DET
admet-2043	347	22	brain	brain	NOUN
admet-2043	347	23	.	.	PUNCT
admet-2043	348	1	however	however	ADV
admet-2043	348	2	,	,	PUNCT
admet-2043	348	3	it	it	PRON
admet-2043	348	4	is	be	AUX
admet-2043	348	5	crucial	crucial	ADJ
admet-2043	348	6	to	to	PART
admet-2043	348	7	acknowledge	acknowledge	VERB
admet-2043	348	8	the	the	DET
admet-2043	348	9	potential	potential	ADJ
admet-2043	348	10	downsides	downside	NOUN
admet-2043	348	11	,	,	PUNCT
admet-2043	348	12	including	include	VERB
admet-2043	348	13	non	non	NOUN
admet-2043	348	14	-	-	ADJ
admet-2043	348	15	selectivity	selectivity	NOUN
admet-2043	348	16	for	for	ADP
admet-2043	348	17	brain	brain	NOUN
admet-2043	348	18	endothelial	endothelial	ADJ
admet-2043	348	19	cell	cell	NOUN
admet-2043	348	20	receptors	receptor	NOUN
admet-2043	348	21	,	,	PUNCT
admet-2043	348	22	possible	possible	ADJ
admet-2043	348	23	immunogenicity	immunogenicity	NOUN
admet-2043	348	24	,	,	PUNCT
admet-2043	348	25	and	and	CCONJ
admet-2043	348	26	the	the	DET
admet-2043	348	27	intricate	intricate	ADJ
admet-2043	348	28	development	development	NOUN
admet-2043	348	29	process	process	NOUN
admet-2043	348	30	of	of	ADP
admet-2043	348	31	agglutinant	agglutinant	ADJ
admet-2043	348	32	-	-	PUNCT
admet-2043	348	33	mediated	mediate	VERB
admet-2043	348	34	transport	transport	NOUN
admet-2043	348	35	systems	system	NOUN
admet-2043	348	36	.	.	PUNCT
admet-2043	349	1	the	the	DET
admet-2043	349	2	integration	integration	NOUN
admet-2043	349	3	of	of	ADP
admet-2043	349	4	agglutinants	agglutinant	NOUN
admet-2043	349	5	,	,	PUNCT
admet-2043	349	6	while	while	SCONJ
admet-2043	349	7	presenting	present	VERB
admet-2043	349	8	challenges	challenge	NOUN
admet-2043	349	9	,	,	PUNCT
admet-2043	349	10	holds	hold	VERB
admet-2043	349	11	promise	promise	NOUN
admet-2043	349	12	for	for	ADP
admet-2043	349	13	revolutionizing	revolutionize	VERB
admet-2043	349	14	drug	drug	NOUN
admet-2043	349	15	delivery	delivery	NOUN
admet-2043	349	16	and	and	CCONJ
admet-2043	349	17	advancing	advance	VERB
admet-2043	349	18	therapeutic	therapeutic	ADJ
admet-2043	349	19	outcomes	outcome	NOUN
admet-2043	349	20	for	for	ADP
admet-2043	349	21	brain	brain	NOUN
admet-2043	349	22	-	-	PUNCT
admet-2043	349	23	related	relate	VERB
admet-2043	349	24	conditions	condition	NOUN
admet-2043	349	25	.	.	PUNCT
admet-2043	350	1	the	the	DET
admet-2043	350	2	author	author	NOUN
admet-2043	350	3	's	's	PART
admet-2043	350	4	viewpoint	viewpoint	NOUN
admet-2043	350	5	underscores	underscore	VERB
admet-2043	350	6	the	the	DET
admet-2043	350	7	need	need	NOUN
admet-2043	350	8	for	for	ADP
admet-2043	350	9	further	further	ADJ
admet-2043	350	10	research	research	NOUN
admet-2043	350	11	and	and	CCONJ
admet-2043	350	12	careful	careful	ADJ
admet-2043	350	13	consideration	consideration	NOUN
admet-2043	350	14	of	of	ADP
admet-2043	350	15	limitations	limitation	NOUN
admet-2043	350	16	to	to	PART
admet-2043	350	17	fully	fully	ADV
admet-2043	350	18	exploit	exploit	VERB
admet-2043	350	19	the	the	DET
admet-2043	350	20	potential	potential	NOUN
admet-2043	350	21	of	of	ADP
admet-2043	350	22	these	these	DET
admet-2043	350	23	approaches	approach	NOUN
admet-2043	350	24	.	.	PUNCT
admet-2043	351	1	nanoparticles	nanoparticle	NOUN
admet-2043	351	2	for	for	ADP
admet-2043	351	3	drug	drug	NOUN
admet-2043	351	4	delivery	delivery	NOUN
admet-2043	351	5	across	across	ADP
admet-2043	351	6	the	the	DET
admet-2043	351	7	blood	blood	NOUN
admet-2043	351	8	-	-	PUNCT
admet-2043	351	9	brain	brain	NOUN
admet-2043	351	10	barrier	barrier	NOUN
admet-2043	351	11	various	various	ADJ
admet-2043	351	12	nanoparticulate	nanoparticulate	ADJ
admet-2043	351	13	drug	drug	NOUN
admet-2043	351	14	delivery	delivery	NOUN
admet-2043	351	15	systems	system	NOUN
admet-2043	351	16	have	have	AUX
admet-2043	351	17	been	be	AUX
admet-2043	351	18	developed	develop	VERB
admet-2043	351	19	to	to	PART
admet-2043	351	20	enhance	enhance	VERB
admet-2043	351	21	drug	drug	NOUN
admet-2043	351	22	transport	transport	NOUN
admet-2043	351	23	across	across	ADP
admet-2043	351	24	the	the	DET
admet-2043	351	25	highly	highly	ADV
admet-2043	351	26	selective	selective	ADJ
admet-2043	351	27	blood	blood	NOUN
admet-2043	351	28	-	-	PUNCT
admet-2043	351	29	brain	brain	NOUN
admet-2043	351	30	barrier	barrier	NOUN
admet-2043	351	31	(	(	PUNCT
admet-2043	351	32	bbb	bbb	NOUN
admet-2043	351	33	)	)	PUNCT
admet-2043	351	34	and	and	CCONJ
admet-2043	351	35	into	into	ADP
admet-2043	351	36	the	the	DET
admet-2043	351	37	brain	brain	NOUN
admet-2043	351	38	.	.	PUNCT
admet-2043	352	1	polymeric	polymeric	ADJ
admet-2043	352	2	nanoparticles	nanoparticle	NOUN
admet-2043	352	3	as	as	ADP
admet-2043	352	4	a	a	DET
admet-2043	352	5	result	result	NOUN
admet-2043	352	6	of	of	ADP
admet-2043	352	7	their	their	PRON
admet-2043	352	8	hydrophilic	hydrophilic	ADJ
admet-2043	352	9	polymer	polymer	NOUN
admet-2043	352	10	covering	covering	NOUN
admet-2043	352	11	and	and	CCONJ
admet-2043	352	12	core	core	NOUN
admet-2043	352	13	-	-	PUNCT
admet-2043	352	14	shell	shell	NOUN
admet-2043	352	15	structure	structure	NOUN
admet-2043	352	16	,	,	PUNCT
admet-2043	352	17	polymeric	polymeric	NOUN
admet-2043	352	18	-	-	PUNCT
admet-2043	352	19	based	base	VERB
admet-2043	352	20	nps	nps	PROPN
admet-2043	352	21	are	be	AUX
admet-2043	352	22	an	an	DET
admet-2043	352	23	appealing	appealing	ADJ
admet-2043	352	24	option	option	NOUN
admet-2043	352	25	for	for	ADP
admet-2043	352	26	medication	medication	NOUN
admet-2043	352	27	administration	administration	NOUN
admet-2043	352	28	across	across	ADP
admet-2043	352	29	the	the	DET
admet-2043	352	30	bbb	bbb	NOUN
admet-2043	353	1	[	[	X
admet-2043	353	2	102	102	NUM
admet-2043	353	3	]	]	PUNCT
admet-2043	353	4	.	.	PUNCT
admet-2043	354	1	the	the	DET
admet-2043	354	2	development	development	NOUN
admet-2043	354	3	of	of	ADP
admet-2043	354	4	polymer	polymer	NOUN
admet-2043	354	5	-	-	PUNCT
admet-2043	354	6	based	base	VERB
admet-2043	354	7	transport	transport	NOUN
admet-2043	354	8	carriers	carrier	NOUN
admet-2043	354	9	frequently	frequently	ADV
admet-2043	354	10	makes	make	VERB
admet-2043	354	11	use	use	NOUN
admet-2043	354	12	of	of	ADP
admet-2043	354	13	synthetic	synthetic	ADJ
admet-2043	354	14	polymers	polymer	NOUN
admet-2043	354	15	such	such	ADJ
admet-2043	354	16	as	as	ADP
admet-2043	354	17	polyethylene	polyethylene	NOUN
admet-2043	354	18	glycol	glycol	NOUN
admet-2043	354	19	(	(	PUNCT
admet-2043	354	20	peg	peg	NOUN
admet-2043	354	21	)	)	PUNCT
admet-2043	354	22	,	,	PUNCT
admet-2043	354	23	poly(lactic	poly(lactic	ADJ
admet-2043	354	24	acid	acid	NOUN
admet-2043	354	25	)	)	PUNCT
admet-2043	354	26	(	(	PUNCT
admet-2043	354	27	pla	pla	NOUN
admet-2043	354	28	)	)	PUNCT
admet-2043	354	29	and	and	CCONJ
admet-2043	354	30	poly(lactide	poly(lactide	NOUN
admet-2043	354	31	-	-	PUNCT
admet-2043	354	32	coglycolic	coglycolic	NOUN
admet-2043	354	33	-	-	PUNCT
admet-2043	354	34	acid	acid	NOUN
admet-2043	354	35	)	)	PUNCT
admet-2043	354	36	(	(	PUNCT
admet-2043	354	37	plga	plga	NOUN
admet-2043	354	38	)	)	PUNCT
admet-2043	355	1	[	[	X
admet-2043	355	2	103	103	NUM
admet-2043	355	3	,	,	PUNCT
admet-2043	355	4	104	104	NUM
admet-2043	355	5	]	]	PUNCT
admet-2043	355	6	.	.	PUNCT
admet-2043	356	1	considerable	considerable	ADJ
admet-2043	356	2	attention	attention	NOUN
admet-2043	356	3	has	have	AUX
admet-2043	356	4	been	be	AUX
admet-2043	356	5	devoted	devote	VERB
admet-2043	356	6	to	to	ADP
admet-2043	356	7	investigating	investigate	VERB
admet-2043	356	8	the	the	DET
admet-2043	356	9	utilisation	utilisation	NOUN
admet-2043	356	10	of	of	ADP
admet-2043	356	11	polymeric	polymeric	ADJ
admet-2043	356	12	nps	nps	PROPN
admet-2043	356	13	for	for	ADP
admet-2043	356	14	the	the	DET
admet-2043	356	15	enhancement	enhancement	NOUN
admet-2043	356	16	of	of	ADP
admet-2043	356	17	chemotherapy	chemotherapy	NOUN
admet-2043	356	18	administration	administration	NOUN
admet-2043	356	19	to	to	ADP
admet-2043	356	20	cerebral	cerebral	ADJ
admet-2043	356	21	neoplasms	neoplasm	NOUN
admet-2043	356	22	.	.	PUNCT
admet-2043	357	1	an	an	DET
admet-2043	357	2	exemplary	exemplary	ADJ
admet-2043	357	3	illustration	illustration	NOUN
admet-2043	357	4	entails	entail	VERB
admet-2043	357	5	the	the	DET
admet-2043	357	6	implementation	implementation	NOUN
admet-2043	357	7	of	of	ADP
admet-2043	357	8	polylactic	polylactic	ADJ
admet-2043	357	9	acid	acid	NOUN
admet-2043	357	10	nanoparticles	nanoparticle	NOUN
admet-2043	357	11	(	(	PUNCT
admet-2043	357	12	pla	pla	PROPN
admet-2043	357	13	nps	nps	PROPN
admet-2043	357	14	)	)	PUNCT
admet-2043	357	15	that	that	PRON
admet-2043	357	16	have	have	AUX
admet-2043	357	17	been	be	AUX
admet-2043	357	18	coated	coat	VERB
admet-2043	357	19	with	with	ADP
admet-2043	357	20	transferrin	transferrin	NOUN
admet-2043	357	21	(	(	PUNCT
admet-2043	357	22	tf	tf	INTJ
admet-2043	357	23	)	)	PUNCT
admet-2043	357	24	to	to	PART
admet-2043	357	25	facilitate	facilitate	VERB
admet-2043	357	26	the	the	DET
admet-2043	357	27	transportation	transportation	NOUN
admet-2043	357	28	of	of	ADP
admet-2043	357	29	the	the	DET
admet-2043	357	30	anticancer	anticancer	NOUN
admet-2043	357	31	agent	agent	NOUN
admet-2043	357	32	3	3	NUM
admet-2043	357	33	-	-	PUNCT
admet-2043	357	34	bis(2	bis(2	NOUN
admet-2043	357	35	-	-	PUNCT
admet-2043	357	36	chloroethyl)-1	chloroethyl)-1	PROPN
admet-2043	357	37	-	-	PUNCT
admet-2043	357	38	nitrosourea	nitrosourea	NOUN
admet-2043	357	39	.	.	PUNCT
admet-2043	358	1	the	the	DET
admet-2043	358	2	present	present	ADJ
admet-2043	358	3	methodology	methodology	NOUN
admet-2043	358	4	has	have	AUX
admet-2043	358	5	exhibited	exhibit	VERB
admet-2043	358	6	noteworthy	noteworthy	ADJ
admet-2043	358	7	outcomes	outcome	NOUN
admet-2043	358	8	in	in	ADP
admet-2043	358	9	augmenting	augment	VERB
admet-2043	358	10	the	the	DET
admet-2043	358	11	survival	survival	NOUN
admet-2043	358	12	rates	rate	NOUN
admet-2043	358	13	in	in	ADP
admet-2043	358	14	a	a	DET
admet-2043	358	15	murine	murine	ADJ
admet-2043	358	16	glioma	glioma	NOUN
admet-2043	358	17	model	model	NOUN
admet-2043	358	18	,	,	PUNCT
admet-2043	358	19	thereby	thereby	ADV
admet-2043	358	20	underscoring	underscore	VERB
admet-2043	358	21	the	the	DET
admet-2043	358	22	inherent	inherent	ADJ
admet-2043	358	23	capacity	capacity	NOUN
admet-2043	358	24	of	of	ADP
admet-2043	358	25	polymeric	polymeric	ADJ
admet-2043	358	26	nanoparticles	nanoparticle	NOUN
admet-2043	358	27	(	(	PUNCT
admet-2043	358	28	nps	nps	PROPN
admet-2043	358	29	)	)	PUNCT
admet-2043	358	30	to	to	PART
admet-2043	358	31	enhance	enhance	VERB
admet-2043	358	32	the	the	DET
admet-2043	358	33	effectiveness	effectiveness	NOUN
admet-2043	358	34	of	of	ADP
admet-2043	358	35	therapeutic	therapeutic	ADJ
admet-2043	358	36	interventions	intervention	NOUN
admet-2043	358	37	[	[	X
admet-2043	358	38	102	102	NUM
admet-2043	358	39	]	]	PUNCT
admet-2043	358	40	.	.	PUNCT
admet-2043	359	1	in	in	ADP
admet-2043	359	2	line	line	NOUN
admet-2043	359	3	with	with	ADP
admet-2043	359	4	this	this	PRON
admet-2043	359	5	,	,	PUNCT
admet-2043	359	6	in	in	ADP
admet-2043	359	7	vitro	vitro	X
admet-2043	359	8	investigations	investigation	NOUN
admet-2043	359	9	utilising	utilise	VERB
admet-2043	359	10	poly(lactic	poly(lactic	NOUN
admet-2043	359	11	-	-	PUNCT
admet-2043	359	12	co	co	NOUN
admet-2043	359	13	-	-	ADJ
admet-2043	359	14	glycolic	glycolic	ADJ
admet-2043	359	15	acid	acid	NOUN
admet-2043	359	16	)	)	PUNCT
admet-2043	359	17	nanoparticles	nanoparticle	NOUN
admet-2043	359	18	(	(	PUNCT
admet-2043	359	19	plga	plga	NOUN
admet-2043	359	20	nps	nps	PROPN
admet-2043	359	21	)	)	PUNCT
admet-2043	359	22	to	to	PART
admet-2043	359	23	deliver	deliver	VERB
admet-2043	359	24	curcumin	curcumin	NOUN
admet-2043	359	25	to	to	PART
admet-2043	359	26	facilitate	facilitate	VERB
admet-2043	359	27	the	the	DET
admet-2043	359	28	dissolution	dissolution	NOUN
admet-2043	359	29	of	of	ADP
admet-2043	359	30	amyloid	amyloid	NOUN
admet-2043	359	31	-	-	PUNCT
admet-2043	359	32	aggregates	aggregate	NOUN
admet-2043	359	33	have	have	AUX
admet-2043	359	34	demonstrated	demonstrate	VERB
admet-2043	359	35	an	an	DET
admet-2043	359	36	absence	absence	NOUN
admet-2043	359	37	of	of	ADP
admet-2043	359	38	discernible	discernible	ADJ
admet-2043	359	39	toxicity	toxicity	NOUN
admet-2043	359	40	towards	towards	ADP
admet-2043	359	41	the	the	DET
admet-2043	359	42	hippocampus	hippocampus	NOUN
admet-2043	359	43	cell	cell	NOUN
admet-2043	359	44	culture	culture	NOUN
admet-2043	360	1	[	[	X
admet-2043	360	2	105	105	NUM
admet-2043	360	3	]	]	PUNCT
admet-2043	360	4	.	.	PUNCT
admet-2043	361	1	nevertheless	nevertheless	ADV
admet-2043	361	2	,	,	PUNCT
admet-2043	361	3	it	it	PRON
admet-2043	361	4	is	be	AUX
admet-2043	361	5	imperative	imperative	ADJ
admet-2043	361	6	to	to	PART
admet-2043	361	7	acknowledge	acknowledge	VERB
admet-2043	361	8	that	that	SCONJ
admet-2043	361	9	polymeric	polymeric	ADJ
admet-2043	361	10	nanoparticles	nanoparticle	NOUN
admet-2043	361	11	exhibit	exhibit	VERB
admet-2043	361	12	notable	notable	ADJ
admet-2043	361	13	limitations	limitation	NOUN
admet-2043	361	14	,	,	PUNCT
admet-2043	361	15	including	include	VERB
admet-2043	361	16	suboptimal	suboptimal	ADJ
admet-2043	361	17	drug	drug	NOUN
admet-2043	361	18	loading	loading	NOUN
admet-2043	361	19	capacity	capacity	NOUN
admet-2043	361	20	,	,	PUNCT
admet-2043	361	21	restricted	restrict	VERB
admet-2043	361	22	transfection	transfection	NOUN
admet-2043	361	23	efficacy	efficacy	NOUN
admet-2043	361	24	,	,	PUNCT
admet-2043	361	25	and	and	CCONJ
admet-2043	361	26	the	the	DET
admet-2043	361	27	propensity	propensity	NOUN
admet-2043	361	28	for	for	ADP
admet-2043	361	29	particle	particle	NOUN
admet-2043	361	30	-	-	PUNCT
admet-2043	361	31	particle	particle	NOUN
admet-2043	361	32	aggregation	aggregation	NOUN
admet-2043	361	33	.	.	PUNCT
admet-2043	362	1	these	these	DET
admet-2043	362	2	inherent	inherent	ADJ
admet-2043	362	3	challenges	challenge	NOUN
admet-2043	362	4	pose	pose	VERB
admet-2043	362	5	considerable	considerable	ADJ
admet-2043	362	6	obstacles	obstacle	NOUN
admet-2043	362	7	in	in	ADP
admet-2043	362	8	effectively	effectively	ADV
admet-2043	362	9	managing	manage	VERB
admet-2043	362	10	and	and	CCONJ
admet-2043	362	11	harnessing	harness	VERB
admet-2043	362	12	the	the	DET
admet-2043	362	13	potential	potential	NOUN
admet-2043	362	14	of	of	ADP
admet-2043	362	15	these	these	DET
admet-2043	362	16	nanocarriers	nanocarrier	NOUN
admet-2043	362	17	[	[	X
admet-2043	362	18	106	106	NUM
admet-2043	362	19	]	]	PUNCT
admet-2043	362	20	.	.	PUNCT
admet-2043	363	1	various	various	ADJ
admet-2043	363	2	targeting	targeting	NOUN
admet-2043	363	3	strategies	strategy	NOUN
admet-2043	363	4	have	have	AUX
admet-2043	363	5	been	be	AUX
admet-2043	363	6	devised	devise	VERB
admet-2043	363	7	to	to	PART
admet-2043	363	8	enhance	enhance	VERB
admet-2043	363	9	the	the	DET
admet-2043	363	10	brain	brain	NOUN
admet-2043	363	11	-	-	PUNCT
admet-2043	363	12	specific	specific	ADJ
admet-2043	363	13	delivery	delivery	NOUN
admet-2043	363	14	of	of	ADP
admet-2043	363	15	polymer	polymer	NOUN
admet-2043	363	16	-	-	PUNCT
admet-2043	363	17	based	base	VERB
admet-2043	363	18	nps	nps	PROPN
admet-2043	363	19	,	,	PUNCT
admet-2043	363	20	thereby	thereby	ADV
admet-2043	363	21	addressing	address	VERB
admet-2043	363	22	the	the	DET
admet-2043	363	23	aforementioned	aforementioned	ADJ
admet-2043	363	24	limitations	limitation	NOUN
admet-2043	363	25	.	.	PUNCT
admet-2043	364	1	these	these	DET
admet-2043	364	2	approaches	approach	NOUN
admet-2043	364	3	encompass	encompass	VERB
admet-2043	364	4	surface	surface	NOUN
admet-2043	364	5	modifications	modification	NOUN
admet-2043	364	6	employing	employ	VERB
admet-2043	364	7	specific	specific	ADJ
admet-2043	364	8	ligands	ligand	NOUN
admet-2043	364	9	or	or	CCONJ
admet-2043	364	10	antibodies	antibody	NOUN
admet-2043	364	11	,	,	PUNCT
admet-2043	364	12	as	as	ADV
admet-2043	364	13	well	well	ADV
admet-2043	364	14	as	as	ADP
admet-2043	364	15	the	the	DET
admet-2043	364	16	utilisation	utilisation	NOUN
admet-2043	364	17	of	of	ADP
admet-2043	364	18	stimuli	stimulus	NOUN
admet-2043	364	19	-	-	PUNCT
admet-2043	364	20	responsive	responsive	ADJ
admet-2043	364	21	materials	material	NOUN
admet-2043	364	22	.	.	PUNCT
admet-2043	365	1	in	in	ADP
admet-2043	365	2	pursuit	pursuit	NOUN
admet-2043	365	3	of	of	ADP
admet-2043	365	4	enhancing	enhance	VERB
admet-2043	365	5	therapeutic	therapeutic	ADJ
admet-2043	365	6	efficacy	efficacy	NOUN
admet-2043	365	7	and	and	CCONJ
admet-2043	365	8	mitigating	mitigate	VERB
admet-2043	365	9	untoward	untoward	ADJ
admet-2043	365	10	reactions	reaction	NOUN
admet-2043	365	11	,	,	PUNCT
admet-2043	365	12	extensive	extensive	ADJ
admet-2043	365	13	investigations	investigation	NOUN
admet-2043	365	14	have	have	AUX
admet-2043	365	15	been	be	AUX
admet-2043	365	16	conducted	conduct	VERB
admet-2043	365	17	on	on	ADP
admet-2043	365	18	the	the	DET
admet-2043	365	19	utilisation	utilisation	NOUN
admet-2043	365	20	of	of	ADP
admet-2043	365	21	combination	combination	NOUN
admet-2043	365	22	therapies	therapy	NOUN
admet-2043	365	23	[	[	X
admet-2043	365	24	107	107	NUM
admet-2043	365	25	]	]	PUNCT
admet-2043	365	26	.	.	PUNCT
admet-2043	366	1	the	the	DET
admet-2043	366	2	investigation	investigation	NOUN
admet-2043	366	3	of	of	ADP
admet-2043	366	4	biodegradable	biodegradable	ADJ
admet-2043	366	5	polymers	polymer	NOUN
admet-2043	366	6	,	,	PUNCT
admet-2043	366	7	namely	namely	ADV
admet-2043	366	8	plga	plga	NOUN
admet-2043	366	9	and	and	CCONJ
admet-2043	366	10	pcl	pcl	PROPN
admet-2043	366	11	(	(	PUNCT
admet-2043	366	12	polycaprolactone	polycaprolactone	NOUN
admet-2043	366	13	)	)	PUNCT
admet-2043	366	14	,	,	PUNCT
admet-2043	366	15	has	have	AUX
admet-2043	366	16	been	be	AUX
admet-2043	366	17	undertaken	undertake	VERB
admet-2043	366	18	to	to	PART
admet-2043	366	19	identify	identify	VERB
admet-2043	366	20	potential	potential	ADJ
admet-2043	366	21	substitutes	substitute	NOUN
admet-2043	366	22	for	for	ADP
admet-2043	366	23	the	the	DET
admet-2043	366	24	quest	quest	NOUN
admet-2043	366	25	for	for	ADP
admet-2043	366	26	an	an	DET
admet-2043	366	27	optimised	optimise	VERB
admet-2043	366	28	drug	drug	NOUN
admet-2043	366	29	delivery	delivery	NOUN
admet-2043	366	30	system	system	NOUN
admet-2043	366	31	specifically	specifically	ADV
admet-2043	366	32	tailored	tailor	VERB
admet-2043	366	33	for	for	ADP
admet-2043	366	34	cerebral	cerebral	ADJ
admet-2043	366	35	applications	application	NOUN
admet-2043	366	36	.	.	PUNCT
admet-2043	367	1	according	accord	VERB
admet-2043	367	2	to	to	ADP
admet-2043	367	3	recent	recent	ADJ
admet-2043	367	4	research	research	NOUN
admet-2043	367	5	findings	finding	NOUN
admet-2043	367	6	,	,	PUNCT
admet-2043	367	7	it	it	PRON
admet-2043	367	8	has	have	AUX
admet-2043	367	9	been	be	AUX
admet-2043	367	10	observed	observe	VERB
admet-2043	367	11	that	that	SCONJ
admet-2043	367	12	pcl	pcl	PROPN
admet-2043	367	13	nanoparticles	nanoparticle	NOUN
admet-2043	367	14	,	,	PUNCT
admet-2043	367	15	when	when	SCONJ
admet-2043	367	16	loaded	load	VERB
admet-2043	367	17	with	with	ADP
admet-2043	367	18	curcumin	curcumin	NOUN
admet-2043	367	19	,	,	PUNCT
admet-2043	367	20	exhibit	exhibit	VERB
admet-2043	367	21	a	a	DET
admet-2043	367	22	superior	superior	ADJ
admet-2043	367	23	ability	ability	NOUN
admet-2043	367	24	to	to	PART
admet-2043	367	25	accumulate	accumulate	VERB
admet-2043	367	26	within	within	ADP
admet-2043	367	27	the	the	DET
admet-2043	367	28	brain	brain	NOUN
admet-2043	367	29	in	in	ADP
admet-2043	367	30	comparison	comparison	NOUN
admet-2043	367	31	to	to	PART
admet-2043	367	32	plga	plga	VERB
admet-2043	367	33	nanoparticles	nanoparticle	NOUN
admet-2043	367	34	.	.	PUNCT
admet-2043	368	1	the	the	DET
admet-2043	368	2	findings	finding	NOUN
admet-2043	368	3	of	of	ADP
admet-2043	368	4	this	this	DET
admet-2043	368	5	study	study	NOUN
admet-2043	368	6	indicate	indicate	VERB
admet-2043	368	7	that	that	SCONJ
admet-2043	368	8	polycaprolactone	polycaprolactone	NOUN
admet-2043	368	9	(	(	PUNCT
admet-2043	368	10	pcl	pcl	PROPN
admet-2043	368	11	)	)	PUNCT
admet-2043	368	12	exhibits	exhibit	VERB
admet-2043	368	13	potential	potential	NOUN
admet-2043	368	14	as	as	ADP
admet-2043	368	15	a	a	DET
admet-2043	368	16	viable	viable	ADJ
admet-2043	368	17	option	option	NOUN
admet-2043	368	18	for	for	ADP
admet-2043	368	19	facilitating	facilitate	VERB
admet-2043	368	20	drug	drug	NOUN
admet-2043	368	21	delivery	delivery	NOUN
admet-2043	368	22	to	to	ADP
admet-2043	368	23	the	the	DET
admet-2043	368	24	central	central	ADJ
admet-2043	368	25	nervous	nervous	ADJ
admet-2043	368	26	system	system	NOUN
admet-2043	368	27	[	[	X
admet-2043	368	28	108	108	NUM
admet-2043	368	29	]	]	PUNCT
admet-2043	368	30	.	.	PUNCT
admet-2043	369	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	369	2	m.	m.	NOUN
admet-2043	369	3	kulkarni	kulkarni	PROPN
admet-2043	369	4	et	et	PROPN
admet-2043	369	5	al	al	PROPN
admet-2043	369	6	.	.	PROPN
admet-2043	369	7	admet	admet	PROPN
admet-2043	369	8	&	&	CCONJ
admet-2043	369	9	dmpk	dmpk	PROPN
admet-2043	369	10	12(1	12(1	PROPN
admet-2043	369	11	)	)	PUNCT
admet-2043	369	12	(	(	PUNCT
admet-2043	369	13	2024	2024	NUM
admet-2043	369	14	)	)	PUNCT
admet-2043	369	15	63	63	NUM
admet-2043	369	16	-	-	SYM
admet-2043	369	17	105	105	NUM
admet-2043	369	18	78	78	NUM
admet-2043	369	19	disorders	disorder	NOUN
admet-2043	369	20	such	such	ADJ
admet-2043	369	21	as	as	ADP
admet-2043	369	22	huntington	huntington	PROPN
admet-2043	369	23	's	's	PART
admet-2043	369	24	disease	disease	NOUN
admet-2043	369	25	(	(	PUNCT
admet-2043	369	26	hd	hd	NOUN
admet-2043	369	27	)	)	PUNCT
admet-2043	369	28	and	and	CCONJ
admet-2043	369	29	alzheimer	alzheimer	PROPN
admet-2043	369	30	's	's	PART
admet-2043	369	31	disease	disease	NOUN
admet-2043	369	32	(	(	PUNCT
admet-2043	369	33	ad	ad	NOUN
admet-2043	369	34	)	)	PUNCT
admet-2043	369	35	are	be	AUX
admet-2043	369	36	being	be	AUX
admet-2043	369	37	treated	treat	VERB
admet-2043	369	38	with	with	ADP
admet-2043	369	39	gene	gene	NOUN
admet-2043	369	40	therapy	therapy	NOUN
admet-2043	369	41	using	use	VERB
admet-2043	369	42	polymer	polymer	NOUN
admet-2043	369	43	-	-	PUNCT
admet-2043	369	44	based	base	VERB
admet-2043	369	45	nanoparticles	nanoparticle	NOUN
admet-2043	369	46	.	.	PUNCT
admet-2043	370	1	small	small	ADJ
admet-2043	370	2	interfering	interfere	VERB
admet-2043	370	3	rna	rna	PROPN
admet-2043	370	4	(	(	PUNCT
admet-2043	370	5	sirna	sirna	PROPN
admet-2043	370	6	)	)	PUNCT
admet-2043	370	7	has	have	AUX
admet-2043	370	8	been	be	AUX
admet-2043	370	9	delivered	deliver	VERB
admet-2043	370	10	using	use	VERB
admet-2043	370	11	plga	plga	NOUN
admet-2043	370	12	nanoparticles	nanoparticle	NOUN
admet-2043	370	13	to	to	PART
admet-2043	370	14	mute	mute	VERB
admet-2043	370	15	the	the	DET
admet-2043	370	16	expression	expression	NOUN
admet-2043	370	17	of	of	ADP
admet-2043	370	18	particular	particular	ADJ
admet-2043	370	19	ad	ad	NOUN
admet-2043	370	20	-	-	PUNCT
admet-2043	370	21	related	relate	VERB
admet-2043	370	22	genes	gene	NOUN
admet-2043	370	23	[	[	X
admet-2043	370	24	109	109	NUM
admet-2043	370	25	]	]	PUNCT
admet-2043	370	26	.	.	PUNCT
admet-2043	371	1	many	many	ADJ
admet-2043	371	2	scientific	scientific	ADJ
admet-2043	371	3	investigations	investigation	NOUN
admet-2043	371	4	have	have	AUX
admet-2043	371	5	substantiated	substantiate	VERB
admet-2043	371	6	the	the	DET
admet-2043	371	7	inherent	inherent	ADJ
admet-2043	371	8	capabilities	capability	NOUN
admet-2043	371	9	of	of	ADP
admet-2043	371	10	polymer	polymer	NOUN
admet-2043	371	11	-	-	PUNCT
admet-2043	371	12	based	base	VERB
admet-2043	371	13	nps	nps	PROPN
admet-2043	371	14	in	in	ADP
admet-2043	371	15	facilitating	facilitate	VERB
admet-2043	371	16	the	the	DET
admet-2043	371	17	transportation	transportation	NOUN
admet-2043	371	18	of	of	ADP
admet-2043	371	19	pharmaceutical	pharmaceutical	ADJ
admet-2043	371	20	agents	agent	NOUN
admet-2043	371	21	across	across	ADP
admet-2043	371	22	the	the	DET
admet-2043	371	23	blood	blood	NOUN
admet-2043	371	24	-	-	PUNCT
admet-2043	371	25	brain	brain	NOUN
admet-2043	371	26	barrier	barrier	NOUN
admet-2043	371	27	.	.	PUNCT
admet-2043	372	1	these	these	DET
admet-2043	372	2	nanoparticles	nanoparticle	NOUN
admet-2043	372	3	have	have	AUX
admet-2043	372	4	exhibited	exhibit	VERB
admet-2043	372	5	promising	promise	VERB
admet-2043	372	6	outcomes	outcome	NOUN
admet-2043	372	7	in	in	ADP
admet-2043	372	8	various	various	ADJ
admet-2043	372	9	domains	domain	NOUN
admet-2043	372	10	,	,	PUNCT
admet-2043	372	11	such	such	ADJ
admet-2043	372	12	as	as	ADP
admet-2043	372	13	the	the	DET
admet-2043	372	14	disintegration	disintegration	NOUN
admet-2043	372	15	of	of	ADP
admet-2043	372	16	amyloid	amyloid	NOUN
admet-2043	372	17	aggregates	aggregate	NOUN
admet-2043	372	18	and	and	CCONJ
admet-2043	372	19	the	the	DET
admet-2043	372	20	dispensation	dispensation	NOUN
admet-2043	372	21	of	of	ADP
admet-2043	372	22	anti	anti	ADJ
admet-2043	372	23	-	-	ADJ
admet-2043	372	24	cancer	cancer	ADJ
admet-2043	372	25	therapeutics	therapeutic	NOUN
admet-2043	372	26	.	.	PUNCT
admet-2043	373	1	the	the	DET
admet-2043	373	2	utilisation	utilisation	NOUN
admet-2043	373	3	of	of	ADP
admet-2043	373	4	polymer	polymer	NOUN
admet-2043	373	5	-	-	PUNCT
admet-2043	373	6	based	base	VERB
admet-2043	373	7	nanoparticles	nanoparticle	NOUN
admet-2043	373	8	has	have	AUX
admet-2043	373	9	been	be	AUX
admet-2043	373	10	investigated	investigate	VERB
admet-2043	373	11	in	in	ADP
admet-2043	373	12	the	the	DET
admet-2043	373	13	context	context	NOUN
admet-2043	373	14	of	of	ADP
admet-2043	373	15	glioblastoma	glioblastoma	NOUN
admet-2043	373	16	multiforme	multiforme	NOUN
admet-2043	373	17	(	(	PUNCT
admet-2043	373	18	gbm	gbm	NOUN
admet-2043	373	19	)	)	PUNCT
admet-2043	373	20	and	and	CCONJ
admet-2043	373	21	brain	brain	NOUN
admet-2043	373	22	metastases	metastasis	NOUN
admet-2043	373	23	originating	originate	VERB
admet-2043	373	24	from	from	ADP
admet-2043	373	25	breast	breast	NOUN
admet-2043	373	26	cancer	cancer	NOUN
admet-2043	373	27	.	.	PUNCT
admet-2043	374	1	the	the	DET
admet-2043	374	2	aforementioned	aforementioned	PROPN
admet-2043	374	3	nps	nps	PROPN
admet-2043	374	4	exhibit	exhibit	VERB
admet-2043	374	5	inherent	inherent	ADJ
admet-2043	374	6	limitations	limitation	NOUN
admet-2043	374	7	that	that	PRON
admet-2043	374	8	pose	pose	VERB
admet-2043	374	9	considerable	considerable	ADJ
admet-2043	374	10	challenges	challenge	NOUN
admet-2043	374	11	in	in	ADP
admet-2043	374	12	their	their	PRON
admet-2043	374	13	management	management	NOUN
admet-2043	374	14	,	,	PUNCT
admet-2043	374	15	whether	whether	SCONJ
admet-2043	374	16	in	in	ADP
admet-2043	374	17	liquid	liquid	ADJ
admet-2043	374	18	or	or	CCONJ
admet-2043	374	19	dry	dry	ADJ
admet-2043	374	20	states	state	NOUN
admet-2043	374	21	.	.	PUNCT
admet-2043	375	1	these	these	DET
admet-2043	375	2	limitations	limitation	NOUN
admet-2043	375	3	encompass	encompass	VERB
admet-2043	375	4	a	a	DET
admet-2043	375	5	range	range	NOUN
admet-2043	375	6	of	of	ADP
admet-2043	375	7	factors	factor	NOUN
admet-2043	375	8	,	,	PUNCT
admet-2043	375	9	such	such	ADJ
admet-2043	375	10	as	as	ADP
admet-2043	375	11	suboptimal	suboptimal	ADJ
admet-2043	375	12	transfection	transfection	NOUN
admet-2043	375	13	efficacy	efficacy	NOUN
admet-2043	375	14	,	,	PUNCT
admet-2043	375	15	fluctuation	fluctuation	NOUN
admet-2043	375	16	in	in	ADP
admet-2043	375	17	performance	performance	NOUN
admet-2043	375	18	across	across	ADP
admet-2043	375	19	different	different	ADJ
admet-2043	375	20	batches	batch	NOUN
admet-2043	375	21	,	,	PUNCT
admet-2043	375	22	limited	limited	ADJ
admet-2043	375	23	capacity	capacity	NOUN
admet-2043	375	24	for	for	ADP
admet-2043	375	25	drug	drug	NOUN
admet-2043	375	26	loading	loading	NOUN
admet-2043	375	27	,	,	PUNCT
admet-2043	375	28	compromised	compromise	VERB
admet-2043	375	29	entrapment	entrapment	ADJ
admet-2043	375	30	efficiency	efficiency	NOUN
admet-2043	375	31	,	,	PUNCT
admet-2043	375	32	and	and	CCONJ
admet-2043	375	33	susceptibility	susceptibility	NOUN
admet-2043	375	34	to	to	ADP
admet-2043	375	35	particle	particle	NOUN
admet-2043	375	36	-	-	PUNCT
admet-2043	375	37	particle	particle	NOUN
admet-2043	375	38	aggregation	aggregation	NOUN
admet-2043	375	39	.	.	PUNCT
admet-2043	376	1	moreover	moreover	ADV
admet-2043	376	2	,	,	PUNCT
admet-2043	376	3	it	it	PRON
admet-2043	376	4	has	have	AUX
admet-2043	376	5	been	be	AUX
admet-2043	376	6	observed	observe	VERB
admet-2043	376	7	that	that	SCONJ
admet-2043	376	8	polycation	polycation	NOUN
admet-2043	376	9	nanocarriers	nanocarrier	NOUN
admet-2043	376	10	elicit	elicit	VERB
admet-2043	376	11	osmotic	osmotic	ADJ
admet-2043	376	12	swelling	swelling	NOUN
admet-2043	376	13	,	,	PUNCT
admet-2043	376	14	resulting	result	VERB
admet-2043	376	15	in	in	ADP
admet-2043	376	16	the	the	DET
admet-2043	376	17	induction	induction	NOUN
admet-2043	376	18	of	of	ADP
admet-2043	376	19	oxidative	oxidative	ADJ
admet-2043	376	20	stress	stress	NOUN
admet-2043	376	21	,	,	PUNCT
admet-2043	376	22	protein	protein	NOUN
admet-2043	376	23	aggregation	aggregation	NOUN
admet-2043	376	24	,	,	PUNCT
admet-2043	376	25	impairment	impairment	NOUN
admet-2043	376	26	of	of	ADP
admet-2043	376	27	mitochondrial	mitochondrial	ADJ
admet-2043	376	28	function	function	NOUN
admet-2043	376	29	,	,	PUNCT
admet-2043	376	30	and	and	CCONJ
admet-2043	376	31	subsequent	subsequent	ADJ
admet-2043	376	32	cellular	cellular	ADJ
admet-2043	376	33	demise	demise	NOUN
admet-2043	376	34	.	.	PUNCT
admet-2043	377	1	the	the	DET
admet-2043	377	2	activation	activation	NOUN
admet-2043	377	3	of	of	ADP
admet-2043	377	4	these	these	DET
admet-2043	377	5	nps	nps	PROPN
admet-2043	377	6	has	have	VERB
admet-2043	377	7	the	the	DET
admet-2043	377	8	potential	potential	NOUN
admet-2043	377	9	to	to	PART
admet-2043	377	10	induce	induce	VERB
admet-2043	377	11	complement	complement	NOUN
admet-2043	377	12	system	system	NOUN
admet-2043	377	13	activation	activation	NOUN
admet-2043	377	14	,	,	PUNCT
admet-2043	377	15	thereby	thereby	ADV
admet-2043	377	16	initiating	initiate	VERB
admet-2043	377	17	an	an	DET
admet-2043	377	18	inflammatory	inflammatory	ADJ
admet-2043	377	19	response	response	NOUN
admet-2043	377	20	[	[	X
admet-2043	377	21	106	106	NUM
admet-2043	377	22	]	]	PUNCT
admet-2043	377	23	.	.	PUNCT
admet-2043	378	1	traditional	traditional	ADJ
admet-2043	378	2	linear	linear	ADJ
admet-2043	378	3	polymers	polymer	NOUN
admet-2043	378	4	offer	offer	VERB
admet-2043	378	5	restricted	restrict	VERB
admet-2043	378	6	areas	area	NOUN
admet-2043	378	7	for	for	ADP
admet-2043	378	8	drug	drug	NOUN
admet-2043	378	9	loading	loading	NOUN
admet-2043	378	10	and	and	CCONJ
admet-2043	378	11	interaction	interaction	NOUN
admet-2043	378	12	,	,	PUNCT
admet-2043	378	13	a	a	DET
admet-2043	378	14	significant	significant	ADJ
admet-2043	378	15	problem	problem	NOUN
admet-2043	378	16	[	[	X
admet-2043	378	17	105	105	NUM
admet-2043	378	18	]	]	PUNCT
admet-2043	378	19	.	.	PUNCT
admet-2043	379	1	it	it	PRON
admet-2043	379	2	is	be	AUX
admet-2043	379	3	important	important	ADJ
admet-2043	379	4	to	to	PART
admet-2043	379	5	remember	remember	VERB
admet-2043	379	6	that	that	SCONJ
admet-2043	379	7	polymers	polymer	NOUN
admet-2043	379	8	can	can	AUX
admet-2043	379	9	be	be	AUX
admet-2043	379	10	of	of	ADP
admet-2043	379	11	various	various	ADJ
admet-2043	379	12	types	type	NOUN
admet-2043	379	13	,	,	PUNCT
admet-2043	379	14	such	such	ADJ
admet-2043	379	15	as	as	ADP
admet-2043	379	16	natural	natural	ADJ
admet-2043	379	17	polymers	polymer	NOUN
admet-2043	379	18	like	like	ADP
admet-2043	379	19	albumin	albumin	NOUN
admet-2043	379	20	and	and	CCONJ
admet-2043	379	21	chitosan	chitosan	NOUN
admet-2043	379	22	,	,	PUNCT
admet-2043	379	23	the	the	DET
admet-2043	379	24	latter	latter	NOUN
admet-2043	379	25	of	of	ADP
admet-2043	379	26	which	which	PRON
admet-2043	379	27	has	have	VERB
admet-2043	379	28	low	low	ADJ
admet-2043	379	29	toxicity	toxicity	NOUN
admet-2043	379	30	levels	level	NOUN
admet-2043	379	31	and	and	CCONJ
admet-2043	379	32	is	be	AUX
admet-2043	379	33	biocompatible	biocompatible	ADJ
admet-2043	379	34	[	[	X
admet-2043	379	35	110	110	NUM
admet-2043	379	36	]	]	PUNCT
admet-2043	379	37	,	,	PUNCT
admet-2043	379	38	although	although	SCONJ
admet-2043	379	39	prolonged	prolonged	ADJ
admet-2043	379	40	use	use	NOUN
admet-2043	379	41	is	be	AUX
admet-2043	379	42	not	not	PART
admet-2043	379	43	recommended	recommend	VERB
admet-2043	379	44	[	[	PUNCT
admet-2043	379	45	111	111	NUM
admet-2043	379	46	]	]	PUNCT
admet-2043	379	47	.	.	PUNCT
admet-2043	380	1	additionally	additionally	ADV
admet-2043	380	2	,	,	PUNCT
admet-2043	380	3	ghosh	ghosh	PROPN
admet-2043	380	4	and	and	CCONJ
admet-2043	380	5	colleagues	colleague	NOUN
admet-2043	380	6	have	have	AUX
admet-2043	380	7	shown	show	VERB
admet-2043	380	8	that	that	DET
admet-2043	380	9	plga	plga	NOUN
admet-2043	380	10	nps	nps	PROPN
admet-2043	380	11	can	can	AUX
admet-2043	380	12	be	be	AUX
admet-2043	380	13	transported	transport	VERB
admet-2043	380	14	across	across	ADP
admet-2043	380	15	the	the	DET
admet-2043	380	16	bbb	bbb	NOUN
admet-2043	380	17	for	for	ADP
admet-2043	380	18	the	the	DET
admet-2043	380	19	treatment	treatment	NOUN
admet-2043	380	20	of	of	ADP
admet-2043	380	21	gliomas	glioma	NOUN
admet-2043	380	22	while	while	SCONJ
admet-2043	380	23	obtaining	obtain	VERB
admet-2043	380	24	high	high	ADJ
admet-2043	380	25	drug	drug	NOUN
admet-2043	380	26	solubility	solubility	NOUN
admet-2043	380	27	and	and	CCONJ
admet-2043	380	28	passage	passage	VERB
admet-2043	380	29	selectivity	selectivity	NOUN
admet-2043	380	30	[	[	X
admet-2043	380	31	112	112	NUM
admet-2043	380	32	]	]	PUNCT
admet-2043	380	33	.	.	PUNCT
admet-2043	381	1	dendrimer	dendrimer	NOUN
admet-2043	381	2	the	the	DET
admet-2043	381	3	delivery	delivery	NOUN
admet-2043	381	4	of	of	ADP
admet-2043	381	5	therapeutics	therapeutic	NOUN
admet-2043	381	6	across	across	ADP
admet-2043	381	7	the	the	DET
admet-2043	381	8	bbb	bbb	PROPN
admet-2043	381	9	is	be	AUX
admet-2043	381	10	obtained	obtain	VERB
admet-2043	381	11	with	with	ADP
admet-2043	381	12	the	the	DET
admet-2043	381	13	help	help	NOUN
admet-2043	381	14	of	of	ADP
admet-2043	381	15	dendrimers	dendrimer	NOUN
admet-2043	381	16	,	,	PUNCT
admet-2043	381	17	which	which	PRON
admet-2043	381	18	are	be	AUX
admet-2043	381	19	highly	highly	ADV
admet-2043	381	20	branched	branched	ADJ
admet-2043	381	21	,	,	PUNCT
admet-2043	381	22	three	three	NUM
admet-2043	381	23	-	-	PUNCT
admet-2043	381	24	dimensional	dimensional	ADJ
admet-2043	381	25	polymers	polymer	NOUN
admet-2043	381	26	[	[	X
admet-2043	381	27	113	113	NUM
admet-2043	381	28	]	]	PUNCT
admet-2043	381	29	.	.	PUNCT
admet-2043	382	1	they	they	PRON
admet-2043	382	2	are	be	AUX
admet-2043	382	3	effective	effective	ADJ
admet-2043	382	4	for	for	ADP
admet-2043	382	5	storing	store	VERB
admet-2043	382	6	a	a	DET
admet-2043	382	7	significant	significant	ADJ
admet-2043	382	8	amount	amount	NOUN
admet-2043	382	9	of	of	ADP
admet-2043	382	10	drugs	drug	NOUN
admet-2043	382	11	since	since	SCONJ
admet-2043	382	12	they	they	PRON
admet-2043	382	13	have	have	VERB
admet-2043	382	14	a	a	DET
admet-2043	382	15	tightly	tightly	ADV
admet-2043	382	16	packed	pack	VERB
admet-2043	382	17	periphery	periphery	NOUN
admet-2043	382	18	and	and	CCONJ
admet-2043	382	19	a	a	DET
admet-2043	382	20	loosely	loosely	ADV
admet-2043	382	21	packed	pack	VERB
admet-2043	382	22	centre	centre	NOUN
admet-2043	382	23	that	that	PRON
admet-2043	382	24	makes	make	VERB
admet-2043	382	25	it	it	PRON
admet-2043	382	26	easier	easy	ADJ
admet-2043	382	27	to	to	PART
admet-2043	382	28	entrap	entrap	VERB
admet-2043	382	29	pharmaceuticals	pharmaceutical	NOUN
admet-2043	382	30	[	[	X
admet-2043	382	31	114	114	NUM
admet-2043	382	32	]	]	PUNCT
admet-2043	382	33	.	.	PUNCT
admet-2043	383	1	in	in	ADP
admet-2043	383	2	comparison	comparison	NOUN
admet-2043	383	3	to	to	ADP
admet-2043	383	4	linear	linear	PROPN
admet-2043	383	5	polymers	polymer	NOUN
admet-2043	383	6	,	,	PUNCT
admet-2043	383	7	dendrimers	dendrimer	NOUN
admet-2043	383	8	are	be	AUX
admet-2043	383	9	more	more	ADV
admet-2043	383	10	advantageous	advantageous	ADJ
admet-2043	383	11	due	due	ADP
admet-2043	383	12	to	to	ADP
admet-2043	383	13	their	their	PRON
admet-2043	383	14	monodispersity	monodispersity	NOUN
admet-2043	383	15	,	,	PUNCT
admet-2043	383	16	water	water	NOUN
admet-2043	383	17	solubility	solubility	NOUN
admet-2043	383	18	,	,	PUNCT
admet-2043	383	19	low	low	ADJ
admet-2043	383	20	toxicity	toxicity	NOUN
admet-2043	383	21	,	,	PUNCT
admet-2043	383	22	high	high	ADJ
admet-2043	383	23	loading	loading	NOUN
admet-2043	383	24	capacity	capacity	NOUN
admet-2043	383	25	,	,	PUNCT
admet-2043	383	26	and	and	CCONJ
admet-2043	383	27	abundance	abundance	NOUN
admet-2043	383	28	of	of	ADP
admet-2043	383	29	changeable	changeable	ADJ
admet-2043	383	30	surface	surface	NOUN
admet-2043	383	31	groups	group	NOUN
admet-2043	383	32	[	[	X
admet-2043	383	33	115	115	NUM
admet-2043	383	34	]	]	PUNCT
admet-2043	383	35	.	.	PUNCT
admet-2043	384	1	the	the	DET
admet-2043	384	2	surfaces	surface	NOUN
admet-2043	384	3	of	of	ADP
admet-2043	384	4	dendrimers	dendrimer	NOUN
admet-2043	384	5	may	may	AUX
admet-2043	384	6	be	be	AUX
admet-2043	384	7	changed	change	VERB
admet-2043	384	8	by	by	ADP
admet-2043	384	9	adding	add	VERB
admet-2043	384	10	various	various	ADJ
admet-2043	384	11	functional	functional	ADJ
admet-2043	384	12	groups	group	NOUN
admet-2043	384	13	and	and	CCONJ
admet-2043	384	14	specific	specific	ADJ
admet-2043	384	15	ligands	ligand	NOUN
admet-2043	384	16	,	,	PUNCT
admet-2043	384	17	and	and	CCONJ
admet-2043	384	18	they	they	PRON
admet-2043	384	19	can	can	AUX
admet-2043	384	20	be	be	AUX
admet-2043	384	21	covalently	covalently	ADV
admet-2043	384	22	coupled	couple	VERB
admet-2043	384	23	to	to	ADP
admet-2043	384	24	pharmaceuticals	pharmaceutical	NOUN
admet-2043	384	25	or	or	CCONJ
admet-2043	384	26	linked	link	VERB
admet-2043	384	27	by	by	ADP
admet-2043	384	28	electrostatic	electrostatic	ADJ
admet-2043	384	29	adsorption	adsorption	NOUN
admet-2043	385	1	[	[	X
admet-2043	385	2	116	116	NUM
admet-2043	385	3	]	]	PUNCT
admet-2043	385	4	.	.	PUNCT
admet-2043	386	1	dendrimers	dendrimer	NOUN
admet-2043	386	2	of	of	ADP
admet-2043	386	3	several	several	ADJ
admet-2043	386	4	varieties	variety	NOUN
admet-2043	386	5	,	,	PUNCT
admet-2043	386	6	including	include	VERB
admet-2043	386	7	polyamidoamine	polyamidoamine	NOUN
admet-2043	386	8	(	(	PUNCT
admet-2043	386	9	pamam	pamam	NOUN
admet-2043	386	10	)	)	PUNCT
admet-2043	386	11	dendrimers	dendrimer	NOUN
admet-2043	386	12	,	,	PUNCT
admet-2043	386	13	polyhydroxylamine	polyhydroxylamine	NOUN
admet-2043	386	14	,	,	PUNCT
admet-2043	386	15	and	and	CCONJ
admet-2043	386	16	polypropylene	polypropylene	PROPN
admet-2043	386	17	amine	amine	NOUN
admet-2043	386	18	,	,	PUNCT
admet-2043	386	19	have	have	AUX
admet-2043	386	20	been	be	AUX
admet-2043	386	21	employed	employ	VERB
admet-2043	386	22	for	for	ADP
admet-2043	386	23	imaging	imaging	NOUN
admet-2043	386	24	and	and	CCONJ
admet-2043	386	25	drug	drug	NOUN
admet-2043	386	26	delivery	delivery	NOUN
admet-2043	386	27	[	[	X
admet-2043	386	28	117	117	NUM
admet-2043	386	29	]	]	PUNCT
admet-2043	386	30	.	.	PUNCT
admet-2043	387	1	the	the	DET
admet-2043	387	2	polyanionic	polyanionic	ADJ
admet-2043	387	3	form	form	NOUN
admet-2043	387	4	of	of	ADP
admet-2043	387	5	pamam	pamam	NOUN
admet-2043	387	6	dendrimers	dendrimer	NOUN
admet-2043	387	7	tends	tend	VERB
admet-2043	387	8	to	to	PART
admet-2043	387	9	be	be	AUX
admet-2043	387	10	less	less	ADV
admet-2043	387	11	harmful	harmful	ADJ
admet-2043	387	12	than	than	ADP
admet-2043	387	13	the	the	DET
admet-2043	387	14	polycationic	polycationic	ADJ
admet-2043	387	15	form	form	NOUN
admet-2043	387	16	.	.	PUNCT
admet-2043	388	1	drug	drug	NOUN
admet-2043	388	2	transportation	transportation	NOUN
admet-2043	388	3	through	through	ADP
admet-2043	388	4	the	the	DET
admet-2043	388	5	bbb	bbb	PROPN
admet-2043	388	6	can	can	AUX
admet-2043	388	7	be	be	AUX
admet-2043	388	8	facilitated	facilitate	VERB
admet-2043	388	9	by	by	ADP
admet-2043	388	10	dendrimer	dendrimer	NOUN
admet-2043	388	11	modifications	modification	NOUN
admet-2043	388	12	with	with	ADP
admet-2043	388	13	ligands	ligand	NOUN
admet-2043	388	14	that	that	PRON
admet-2043	388	15	target	target	VERB
admet-2043	388	16	the	the	DET
admet-2043	388	17	tumour	tumour	NOUN
admet-2043	388	18	or	or	CCONJ
admet-2043	388	19	the	the	DET
admet-2043	388	20	bbb	bbb	NOUN
admet-2043	389	1	[	[	X
admet-2043	389	2	118	118	NUM
admet-2043	389	3	]	]	PUNCT
admet-2043	389	4	.	.	PUNCT
admet-2043	390	1	the	the	DET
admet-2043	390	2	nanocarrier	nanocarrier	NOUN
admet-2043	390	3	acts	act	VERB
admet-2043	390	4	by	by	ADP
admet-2043	390	5	five	five	NUM
admet-2043	390	6	-	-	PUNCT
admet-2043	390	7	stage	stage	NOUN
admet-2043	390	8	mechanisms	mechanism	NOUN
admet-2043	390	9	:	:	PUNCT
admet-2043	390	10	stage	stage	NOUN
admet-2043	390	11	i	i	PRON
admet-2043	390	12	:	:	PUNCT
admet-2043	390	13	dendrimers	dendrimer	NOUN
admet-2043	390	14	undergo	undergo	VERB
admet-2043	390	15	initial	initial	ADJ
admet-2043	390	16	modifications	modification	NOUN
admet-2043	390	17	through	through	ADP
admet-2043	390	18	the	the	DET
admet-2043	390	19	introduction	introduction	NOUN
admet-2043	390	20	of	of	ADP
admet-2043	390	21	surface	surface	NOUN
admet-2043	390	22	or	or	CCONJ
admet-2043	390	23	distance	distance	NOUN
admet-2043	390	24	connections	connection	NOUN
admet-2043	390	25	,	,	PUNCT
admet-2043	390	26	thereby	thereby	ADV
admet-2043	390	27	enhancing	enhance	VERB
admet-2043	390	28	their	their	PRON
admet-2043	390	29	biocompatibility	biocompatibility	NOUN
admet-2043	390	30	,	,	PUNCT
admet-2043	390	31	storage	storage	NOUN
admet-2043	390	32	capacity	capacity	NOUN
admet-2043	390	33	,	,	PUNCT
admet-2043	390	34	and	and	CCONJ
admet-2043	390	35	drug	drug	NOUN
admet-2043	390	36	release	release	NOUN
admet-2043	390	37	kinetics	kinetic	NOUN
admet-2043	390	38	and	and	CCONJ
admet-2043	390	39	rate	rate	NOUN
admet-2043	390	40	.	.	PUNCT
admet-2043	391	1	stage	stage	PROPN
admet-2043	391	2	ii	ii	PROPN
admet-2043	391	3	:	:	PUNCT
admet-2043	391	4	the	the	DET
admet-2043	391	5	primary	primary	ADJ
admet-2043	391	6	emphasis	emphasis	NOUN
admet-2043	391	7	should	should	AUX
admet-2043	391	8	be	be	AUX
admet-2043	391	9	placed	place	VERB
admet-2043	391	10	on	on	ADP
admet-2043	391	11	the	the	DET
admet-2043	391	12	bbb	bbb	NOUN
admet-2043	391	13	and	and	CCONJ
admet-2043	391	14	its	its	PRON
admet-2043	391	15	facilitation	facilitation	NOUN
admet-2043	391	16	of	of	ADP
admet-2043	391	17	drug	drug	NOUN
admet-2043	391	18	delivery	delivery	NOUN
admet-2043	391	19	across	across	ADP
admet-2043	391	20	the	the	DET
admet-2043	391	21	bbb	bbb	PROPN
admet-2043	391	22	.	.	PUNCT
admet-2043	392	1	to	to	PART
admet-2043	392	2	achieve	achieve	VERB
admet-2043	392	3	this	this	PRON
admet-2043	392	4	,	,	PUNCT
admet-2043	392	5	dendrimers	dendrimer	NOUN
admet-2043	392	6	are	be	AUX
admet-2043	392	7	modified	modify	VERB
admet-2043	392	8	with	with	ADP
admet-2043	392	9	specific	specific	ADJ
admet-2043	392	10	ligands	ligand	NOUN
admet-2043	392	11	that	that	PRON
admet-2043	392	12	undergo	undergo	VERB
admet-2043	392	13	superficial	superficial	ADJ
admet-2043	392	14	modifications	modification	NOUN
admet-2043	392	15	.	.	PUNCT
admet-2043	393	1	stage	stage	NOUN
admet-2043	393	2	iii	iii	PROPN
admet-2043	393	3	:	:	PUNCT
admet-2043	393	4	modified	modify	VERB
admet-2043	393	5	dendrimers	dendrimer	NOUN
admet-2043	393	6	create	create	VERB
admet-2043	393	7	intricate	intricate	ADJ
admet-2043	393	8	biological	biological	ADJ
admet-2043	393	9	connections	connection	NOUN
admet-2043	393	10	for	for	ADP
admet-2043	393	11	drug	drug	NOUN
admet-2043	393	12	and	and	CCONJ
admet-2043	393	13	gene	gene	NOUN
admet-2043	393	14	therapy	therapy	NOUN
admet-2043	393	15	.	.	PUNCT
admet-2043	394	1	stage	stage	NOUN
admet-2043	394	2	iv	iv	X
admet-2043	394	3	:	:	PUNCT
admet-2043	394	4	dendritic	dendritic	ADJ
admet-2043	394	5	nanocarriers	nanocarrier	NOUN
admet-2043	394	6	may	may	AUX
admet-2043	394	7	be	be	AUX
admet-2043	394	8	incorporated	incorporate	VERB
admet-2043	394	9	with	with	ADP
admet-2043	394	10	imaging	imaging	NOUN
admet-2043	394	11	agents	agent	NOUN
admet-2043	394	12	via	via	ADP
admet-2043	394	13	covalent	covalent	ADJ
admet-2043	394	14	bonds	bond	NOUN
admet-2043	394	15	,	,	PUNCT
admet-2043	394	16	preventing	prevent	VERB
admet-2043	394	17	the	the	DET
admet-2043	394	18	biological	biological	ADJ
admet-2043	394	19	distribution	distribution	NOUN
admet-2043	394	20	from	from	ADP
admet-2043	394	21	being	be	AUX
admet-2043	394	22	traced	trace	VERB
admet-2043	394	23	.	.	PUNCT
admet-2043	395	1	stage	stage	NOUN
admet-2043	395	2	v	v	NOUN
admet-2043	395	3	:	:	PUNCT
admet-2043	395	4	dendrimers	dendrimer	NOUN
admet-2043	395	5	release	release	VERB
admet-2043	395	6	their	their	PRON
admet-2043	395	7	drug	drug	NOUN
admet-2043	395	8	payload	payload	NOUN
admet-2043	395	9	in	in	ADP
admet-2043	395	10	a	a	DET
admet-2043	395	11	controlled	control	VERB
admet-2043	395	12	and	and	CCONJ
admet-2043	395	13	sustained	sustained	ADJ
admet-2043	395	14	manner	manner	NOUN
admet-2043	395	15	through	through	ADP
admet-2043	395	16	processes	process	NOUN
admet-2043	395	17	such	such	ADJ
admet-2043	395	18	as	as	ADP
admet-2043	395	19	diffusion	diffusion	NOUN
admet-2043	395	20	,	,	PUNCT
admet-2043	395	21	degradation	degradation	NOUN
admet-2043	395	22	,	,	PUNCT
admet-2043	395	23	or	or	CCONJ
admet-2043	395	24	stimuli	stimuli	VERB
admet-2043	395	25	-	-	PUNCT
admet-2043	395	26	responsive	responsive	ADJ
admet-2043	395	27	release	release	NOUN
admet-2043	395	28	.	.	PUNCT
admet-2043	396	1	admet	admet	PROPN
admet-2043	396	2	&	&	CCONJ
admet-2043	396	3	dmpk	dmpk	PROPN
admet-2043	396	4	12(1	12(1	PROPN
admet-2043	396	5	)	)	PUNCT
admet-2043	396	6	(	(	PUNCT
admet-2043	396	7	2024	2024	NUM
admet-2043	396	8	)	)	PUNCT
admet-2043	396	9	63	63	NUM
admet-2043	396	10	-	-	SYM
admet-2043	396	11	105	105	NUM
admet-2043	396	12	nanomaterials	nanomaterial	NOUN
admet-2043	396	13	as	as	ADP
admet-2043	396	14	drug	drug	NOUN
admet-2043	396	15	delivery	delivery	NOUN
admet-2043	396	16	agents	agent	NOUN
admet-2043	396	17	for	for	ADP
admet-2043	396	18	overcoming	overcome	VERB
admet-2043	396	19	bbb	bbb	PROPN
admet-2043	396	20	doi	doi	NOUN
admet-2043	396	21	:	:	PUNCT
admet-2043	396	22	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	396	23	79	79	NUM
admet-2043	396	24	as	as	ADP
admet-2043	396	25	a	a	DET
admet-2043	396	26	result	result	NOUN
admet-2043	396	27	,	,	PUNCT
admet-2043	396	28	they	they	PRON
admet-2043	396	29	offer	offer	VERB
admet-2043	396	30	in	in	ADP
admet-2043	396	31	vivo	vivo	ADJ
admet-2043	396	32	diagnostic	diagnostic	ADJ
admet-2043	396	33	and	and	CCONJ
admet-2043	396	34	imaging	imaging	NOUN
admet-2043	396	35	techniques	technique	NOUN
admet-2043	396	36	.	.	PUNCT
admet-2043	397	1	it	it	PRON
admet-2043	397	2	should	should	AUX
admet-2043	397	3	be	be	AUX
admet-2043	397	4	mentioned	mention	VERB
admet-2043	397	5	that	that	SCONJ
admet-2043	397	6	depending	depend	VERB
admet-2043	397	7	on	on	ADP
admet-2043	397	8	the	the	DET
admet-2043	397	9	circumstances	circumstance	NOUN
admet-2043	397	10	,	,	PUNCT
admet-2043	397	11	the	the	DET
admet-2043	397	12	sequence	sequence	NOUN
admet-2043	397	13	and	and	CCONJ
admet-2043	397	14	emphasis	emphasis	NOUN
admet-2043	397	15	of	of	ADP
admet-2043	397	16	steps	step	NOUN
admet-2043	397	17	ii	ii	PROPN
admet-2043	397	18	and	and	CCONJ
admet-2043	397	19	iii	iii	PROPN
admet-2043	397	20	may	may	AUX
admet-2043	397	21	vary	vary	VERB
admet-2043	397	22	depending	depend	VERB
admet-2043	397	23	on	on	ADP
admet-2043	397	24	specific	specific	ADJ
admet-2043	397	25	circumstances	circumstance	NOUN
admet-2043	397	26	[	[	X
admet-2043	397	27	113	113	NUM
admet-2043	397	28	]	]	PUNCT
admet-2043	397	29	.	.	PUNCT
admet-2043	398	1	they	they	PRON
admet-2043	398	2	have	have	AUX
admet-2043	398	3	been	be	AUX
admet-2043	398	4	shown	show	VERB
admet-2043	398	5	to	to	PART
admet-2043	398	6	improve	improve	VERB
admet-2043	398	7	the	the	DET
admet-2043	398	8	uptake	uptake	NOUN
admet-2043	398	9	of	of	ADP
admet-2043	398	10	medicines	medicine	NOUN
admet-2043	398	11	and	and	CCONJ
admet-2043	398	12	dna	dna	NOUN
admet-2043	398	13	in	in	ADP
admet-2043	398	14	the	the	DET
admet-2043	398	15	brain	brain	NOUN
admet-2043	398	16	and	and	CCONJ
admet-2043	398	17	have	have	VERB
admet-2043	398	18	good	good	ADJ
admet-2043	398	19	promise	promise	NOUN
admet-2043	398	20	for	for	ADP
admet-2043	398	21	brain	brain	NOUN
admet-2043	398	22	delivery	delivery	NOUN
admet-2043	398	23	.	.	PUNCT
admet-2043	399	1	lamivudine	lamivudine	NOUN
admet-2043	399	2	-	-	PUNCT
admet-2043	399	3	loaded	load	VERB
admet-2043	399	4	mannosylated	mannosylate	VERB
admet-2043	399	5	dendrimers	dendrimer	NOUN
admet-2043	399	6	have	have	AUX
admet-2043	399	7	shown	show	VERB
admet-2043	399	8	improved	improve	VERB
admet-2043	399	9	antiretroviral	antiretroviral	ADJ
admet-2043	399	10	efficacy	efficacy	NOUN
admet-2043	399	11	in	in	ADP
admet-2043	399	12	vitro	vitro	X
admet-2043	399	13	[	[	X
admet-2043	399	14	34	34	NUM
admet-2043	399	15	]	]	PUNCT
admet-2043	399	16	.	.	PUNCT
admet-2043	400	1	other	other	ADJ
admet-2043	400	2	targeted	target	VERB
admet-2043	400	3	ligands	ligand	NOUN
admet-2043	400	4	,	,	PUNCT
admet-2043	400	5	such	such	ADJ
admet-2043	400	6	as	as	ADP
admet-2043	400	7	lactoferrin	lactoferrin	NOUN
admet-2043	400	8	and	and	CCONJ
admet-2043	400	9	transferrin	transferrin	NOUN
admet-2043	400	10	,	,	PUNCT
admet-2043	400	11	have	have	AUX
admet-2043	400	12	also	also	ADV
admet-2043	400	13	been	be	AUX
admet-2043	400	14	effectively	effectively	ADV
admet-2043	400	15	functionalized	functionalize	VERB
admet-2043	400	16	onto	onto	ADP
admet-2043	400	17	dendrimers	dendrimer	NOUN
admet-2043	400	18	for	for	ADP
admet-2043	400	19	transcytosis	transcytosis	NOUN
admet-2043	400	20	over	over	ADP
admet-2043	400	21	the	the	DET
admet-2043	400	22	bbb	bbb	NOUN
admet-2043	400	23	;	;	PUNCT
admet-2043	400	24	both	both	DET
admet-2043	400	25	formulations	formulation	NOUN
admet-2043	400	26	were	be	AUX
admet-2043	400	27	found	find	VERB
admet-2043	400	28	to	to	PART
admet-2043	400	29	have	have	VERB
admet-2043	400	30	a	a	DET
admet-2043	400	31	higher	high	ADJ
admet-2043	400	32	bbb	bbb	NOUN
admet-2043	400	33	crossing	crossing	NOUN
admet-2043	400	34	potential	potential	NOUN
admet-2043	400	35	than	than	ADP
admet-2043	400	36	their	their	PRON
admet-2043	400	37	unmodified	unmodified	ADJ
admet-2043	400	38	counterparts	counterpart	NOUN
admet-2043	400	39	[	[	X
admet-2043	400	40	111	111	NUM
admet-2043	400	41	]	]	PUNCT
admet-2043	400	42	.	.	PUNCT
admet-2043	401	1	nevertheless	nevertheless	ADV
admet-2043	401	2	,	,	PUNCT
admet-2043	401	3	it	it	PRON
admet-2043	401	4	is	be	AUX
admet-2043	401	5	imperative	imperative	ADJ
admet-2043	401	6	to	to	PART
admet-2043	401	7	acknowledge	acknowledge	VERB
admet-2043	401	8	that	that	SCONJ
admet-2043	401	9	dendrimers	dendrimer	NOUN
admet-2043	401	10	exhibit	exhibit	VERB
admet-2043	401	11	certain	certain	ADJ
admet-2043	401	12	inherent	inherent	ADJ
admet-2043	401	13	limitations	limitation	NOUN
admet-2043	401	14	that	that	PRON
admet-2043	401	15	warrant	warrant	VERB
admet-2043	401	16	careful	careful	ADJ
admet-2043	401	17	consideration	consideration	NOUN
admet-2043	401	18	.	.	PUNCT
admet-2043	402	1	these	these	DET
admet-2043	402	2	limitations	limitation	NOUN
admet-2043	402	3	encompass	encompass	VERB
admet-2043	402	4	batch	batch	NOUN
admet-2043	402	5	-	-	PUNCT
admet-2043	402	6	to	to	ADP
admet-2043	402	7	-	-	PUNCT
admet-2043	402	8	batch	batch	NOUN
admet-2043	402	9	variability	variability	NOUN
admet-2043	402	10	,	,	PUNCT
admet-2043	402	11	which	which	PRON
admet-2043	402	12	introduces	introduce	VERB
admet-2043	402	13	a	a	DET
admet-2043	402	14	degree	degree	NOUN
admet-2043	402	15	of	of	ADP
admet-2043	402	16	unpredictability	unpredictability	NOUN
admet-2043	402	17	and	and	CCONJ
admet-2043	402	18	necessitates	necessitate	VERB
admet-2043	402	19	meticulous	meticulous	ADJ
admet-2043	402	20	monitoring	monitoring	NOUN
admet-2043	402	21	and	and	CCONJ
admet-2043	402	22	quality	quality	NOUN
admet-2043	402	23	control	control	NOUN
admet-2043	402	24	measures	measure	NOUN
admet-2043	402	25	.	.	PUNCT
admet-2043	403	1	additionally	additionally	ADV
admet-2043	403	2	,	,	PUNCT
admet-2043	403	3	the	the	DET
admet-2043	403	4	synthesis	synthesis	NOUN
admet-2043	403	5	costs	cost	NOUN
admet-2043	403	6	associated	associate	VERB
admet-2043	403	7	with	with	ADP
admet-2043	403	8	dendrimers	dendrimer	NOUN
admet-2043	403	9	are	be	AUX
admet-2043	403	10	notably	notably	ADV
admet-2043	403	11	high	high	ADJ
admet-2043	403	12	,	,	PUNCT
admet-2043	403	13	demanding	demand	VERB
admet-2043	403	14	substantial	substantial	ADJ
admet-2043	403	15	financial	financial	ADJ
admet-2043	403	16	resources	resource	NOUN
admet-2043	403	17	for	for	ADP
admet-2043	403	18	their	their	PRON
admet-2043	403	19	production	production	NOUN
admet-2043	403	20	.	.	PUNCT
admet-2043	404	1	furthermore	furthermore	ADV
admet-2043	404	2	,	,	PUNCT
admet-2043	404	3	the	the	DET
admet-2043	404	4	achievement	achievement	NOUN
admet-2043	404	5	of	of	ADP
admet-2043	404	6	precise	precise	ADJ
admet-2043	404	7	and	and	CCONJ
admet-2043	404	8	targeted	target	VERB
admet-2043	404	9	drug	drug	NOUN
admet-2043	404	10	delivery	delivery	NOUN
admet-2043	404	11	using	use	VERB
admet-2043	404	12	dendrimers	dendrimer	NOUN
admet-2043	404	13	poses	pose	VERB
admet-2043	404	14	significant	significant	ADJ
admet-2043	404	15	challenges	challenge	NOUN
admet-2043	404	16	,	,	PUNCT
admet-2043	404	17	thereby	thereby	ADV
admet-2043	404	18	necessitating	necessitate	VERB
admet-2043	404	19	the	the	DET
admet-2043	404	20	development	development	NOUN
admet-2043	404	21	of	of	ADP
admet-2043	404	22	innovative	innovative	ADJ
admet-2043	404	23	strategies	strategy	NOUN
admet-2043	404	24	to	to	PART
admet-2043	404	25	ensure	ensure	VERB
admet-2043	404	26	optimal	optimal	ADJ
admet-2043	404	27	therapeutic	therapeutic	ADJ
admet-2043	404	28	outcomes	outcome	NOUN
admet-2043	404	29	.	.	PUNCT
admet-2043	405	1	the	the	DET
admet-2043	405	2	potential	potential	NOUN
admet-2043	405	3	for	for	ADP
admet-2043	405	4	elevated	elevated	ADJ
admet-2043	405	5	toxicity	toxicity	NOUN
admet-2043	405	6	is	be	AUX
admet-2043	405	7	a	a	DET
admet-2043	405	8	notable	notable	ADJ
admet-2043	405	9	concern	concern	NOUN
admet-2043	405	10	in	in	ADP
admet-2043	405	11	relation	relation	NOUN
admet-2043	405	12	to	to	ADP
admet-2043	405	13	cationic	cationic	ADJ
admet-2043	405	14	dendrimers	dendrimer	NOUN
admet-2043	405	15	,	,	PUNCT
admet-2043	405	16	which	which	PRON
admet-2043	405	17	can	can	AUX
admet-2043	405	18	be	be	AUX
admet-2043	405	19	ascribed	ascribe	VERB
admet-2043	405	20	to	to	ADP
admet-2043	405	21	the	the	DET
admet-2043	405	22	intricate	intricate	ADJ
admet-2043	405	23	interplay	interplay	NOUN
admet-2043	405	24	between	between	ADP
admet-2043	405	25	the	the	DET
admet-2043	405	26	negatively	negatively	ADV
admet-2043	405	27	charged	charge	VERB
admet-2043	405	28	cellular	cellular	ADJ
admet-2043	405	29	membrane	membrane	NOUN
admet-2043	405	30	and	and	CCONJ
admet-2043	405	31	the	the	DET
admet-2043	405	32	positively	positively	ADV
admet-2043	405	33	charged	charge	VERB
admet-2043	405	34	nanocarrier	nanocarrier	NOUN
admet-2043	405	35	[	[	X
admet-2043	405	36	105	105	NUM
admet-2043	405	37	]	]	PUNCT
admet-2043	405	38	.	.	PUNCT
admet-2043	406	1	the	the	DET
admet-2043	406	2	heterogeneity	heterogeneity	NOUN
admet-2043	406	3	of	of	ADP
admet-2043	406	4	dendrimer	dendrimer	NOUN
admet-2043	406	5	drug	drug	NOUN
admet-2043	406	6	-	-	PUNCT
admet-2043	406	7	release	release	NOUN
admet-2043	406	8	mechanisms	mechanism	NOUN
admet-2043	406	9	and	and	CCONJ
admet-2043	406	10	short	short	ADJ
admet-2043	406	11	-	-	PUNCT
admet-2043	406	12	term	term	NOUN
admet-2043	406	13	release	release	NOUN
admet-2043	406	14	kinetics	kinetic	NOUN
admet-2043	406	15	are	be	AUX
admet-2043	406	16	some	some	DET
admet-2043	406	17	additional	additional	ADJ
admet-2043	406	18	dendrimer	dendrimer	NOUN
admet-2043	406	19	limitations	limitation	NOUN
admet-2043	406	20	that	that	PRON
admet-2043	406	21	may	may	AUX
admet-2043	406	22	cause	cause	VERB
admet-2043	406	23	the	the	DET
admet-2043	406	24	drug	drug	NOUN
admet-2043	406	25	payload	payload	NOUN
admet-2043	406	26	to	to	PART
admet-2043	406	27	be	be	AUX
admet-2043	406	28	prematurely	prematurely	ADV
admet-2043	406	29	released	release	VERB
admet-2043	406	30	prior	prior	ADV
admet-2043	406	31	to	to	ADP
admet-2043	406	32	reaching	reach	VERB
admet-2043	406	33	the	the	DET
admet-2043	406	34	target	target	NOUN
admet-2043	406	35	location	location	NOUN
admet-2043	406	36	[	[	X
admet-2043	406	37	34	34	NUM
admet-2043	406	38	]	]	PUNCT
admet-2043	406	39	.	.	PUNCT
admet-2043	407	1	studies	study	NOUN
admet-2043	407	2	on	on	ADP
admet-2043	407	3	the	the	DET
admet-2043	407	4	effectiveness	effectiveness	NOUN
admet-2043	407	5	of	of	ADP
admet-2043	407	6	dendrimers	dendrimer	NOUN
admet-2043	407	7	have	have	AUX
admet-2043	407	8	shown	show	VERB
admet-2043	407	9	that	that	SCONJ
admet-2043	407	10	the	the	DET
admet-2043	407	11	surface	surface	NOUN
admet-2043	407	12	can	can	AUX
admet-2043	407	13	be	be	AUX
admet-2043	407	14	modified	modify	VERB
admet-2043	407	15	for	for	ADP
admet-2043	407	16	a	a	DET
admet-2043	407	17	particular	particular	ADJ
admet-2043	407	18	purpose	purpose	NOUN
admet-2043	407	19	.	.	PUNCT
admet-2043	408	1	for	for	ADP
admet-2043	408	2	instance	instance	NOUN
admet-2043	408	3	,	,	PUNCT
admet-2043	408	4	pegylation	pegylation	NOUN
admet-2043	408	5	(	(	PUNCT
admet-2043	408	6	a	a	DET
admet-2043	408	7	biochemical	biochemical	ADJ
admet-2043	408	8	modification	modification	NOUN
admet-2043	408	9	procedure	procedure	NOUN
admet-2043	408	10	of	of	ADP
admet-2043	408	11	bioactive	bioactive	ADJ
admet-2043	408	12	molecules	molecule	NOUN
admet-2043	408	13	with	with	ADP
admet-2043	408	14	polyethylene	polyethylene	NOUN
admet-2043	408	15	glycol	glycol	NOUN
admet-2043	408	16	)	)	PUNCT
admet-2043	408	17	or	or	CCONJ
admet-2043	408	18	carbohydrate	carbohydrate	NOUN
admet-2043	408	19	groups	group	NOUN
admet-2043	408	20	exclude	exclude	VERB
admet-2043	408	21	immune	immune	ADJ
admet-2043	408	22	response	response	NOUN
admet-2043	408	23	and	and	CCONJ
admet-2043	408	24	hazardous	hazardous	ADJ
admet-2043	408	25	side	side	NOUN
admet-2043	408	26	effects	effect	NOUN
admet-2043	408	27	,	,	PUNCT
admet-2043	408	28	allowing	allow	VERB
admet-2043	408	29	dendrimers	dendrimer	NOUN
admet-2043	408	30	to	to	PART
admet-2043	408	31	traverse	traverse	VERB
admet-2043	408	32	the	the	DET
admet-2043	408	33	bbb	bbb	PROPN
admet-2043	408	34	.	.	PUNCT
admet-2043	409	1	liposomes	liposome	VERB
admet-2043	409	2	the	the	DET
admet-2043	409	3	spherical	spherical	ADJ
admet-2043	409	4	vesicles	vesicle	NOUN
admet-2043	409	5	known	know	VERB
admet-2043	409	6	as	as	ADP
admet-2043	409	7	liposomes	liposome	NOUN
admet-2043	409	8	have	have	VERB
admet-2043	409	9	an	an	DET
admet-2043	409	10	interior	interior	ADJ
admet-2043	409	11	aqueous	aqueous	ADJ
admet-2043	409	12	space	space	NOUN
admet-2043	409	13	and	and	CCONJ
admet-2043	409	14	one	one	NUM
admet-2043	409	15	or	or	CCONJ
admet-2043	409	16	more	more	ADJ
admet-2043	409	17	lipid	lipid	ADJ
admet-2043	409	18	bilayers	bilayer	NOUN
admet-2043	409	19	.	.	PUNCT
admet-2043	410	1	to	to	PART
admet-2043	410	2	boost	boost	VERB
admet-2043	410	3	their	their	PRON
admet-2043	410	4	stability	stability	NOUN
admet-2043	410	5	in	in	ADP
admet-2043	410	6	vivo	vivo	NOUN
admet-2043	410	7	,	,	PUNCT
admet-2043	410	8	they	they	PRON
admet-2043	410	9	are	be	AUX
admet-2043	410	10	often	often	ADV
admet-2043	410	11	composed	compose	VERB
admet-2043	410	12	of	of	ADP
admet-2043	410	13	amphiphilic	amphiphilic	ADJ
admet-2043	410	14	phospholipids	phospholipid	NOUN
admet-2043	410	15	like	like	ADP
admet-2043	410	16	sphingomyelin	sphingomyelin	NOUN
admet-2043	410	17	and	and	CCONJ
admet-2043	410	18	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2043	410	19	[	[	X
admet-2043	410	20	119	119	NUM
admet-2043	410	21	]	]	PUNCT
admet-2043	410	22	.	.	PUNCT
admet-2043	411	1	the	the	DET
admet-2043	411	2	number	number	NOUN
admet-2043	411	3	and	and	CCONJ
admet-2043	411	4	size	size	NOUN
admet-2043	411	5	of	of	ADP
admet-2043	411	6	lamellae	lamellae	NOUN
admet-2043	411	7	in	in	ADP
admet-2043	411	8	a	a	DET
admet-2043	411	9	liposome	liposome	NOUN
admet-2043	411	10	can	can	AUX
admet-2043	411	11	be	be	AUX
admet-2043	411	12	used	use	VERB
admet-2043	411	13	to	to	PART
admet-2043	411	14	classify	classify	VERB
admet-2043	411	15	them	they	PRON
admet-2043	411	16	.	.	PUNCT
admet-2043	412	1	small	small	ADJ
admet-2043	412	2	unilamellar	unilamellar	ADJ
admet-2043	412	3	vesicles	vesicle	NOUN
admet-2043	412	4	(	(	PUNCT
admet-2043	412	5	suvs	suvs	NOUN
admet-2043	412	6	)	)	PUNCT
admet-2043	412	7	,	,	PUNCT
admet-2043	412	8	smaller	small	ADJ
admet-2043	412	9	than	than	ADP
admet-2043	412	10	100	100	NUM
admet-2043	412	11	nm	nm	NOUN
admet-2043	412	12	in	in	ADP
admet-2043	412	13	size	size	NOUN
admet-2043	412	14	and	and	CCONJ
admet-2043	412	15	only	only	ADV
admet-2043	412	16	contain	contain	VERB
admet-2043	412	17	one	one	NUM
admet-2043	412	18	bilayer	bilayer	NOUN
admet-2043	412	19	,	,	PUNCT
admet-2043	412	20	are	be	AUX
admet-2043	412	21	smaller	small	ADJ
admet-2043	412	22	than	than	ADP
admet-2043	412	23	multilamellar	multilamellar	ADJ
admet-2043	412	24	vesicles	vesicle	NOUN
admet-2043	412	25	(	(	PUNCT
admet-2043	412	26	mlvs	mlvs	NOUN
admet-2043	412	27	)	)	PUNCT
admet-2043	412	28	,	,	PUNCT
admet-2043	412	29	which	which	PRON
admet-2043	412	30	can	can	AUX
admet-2043	412	31	be	be	AUX
admet-2043	412	32	more	more	ADJ
admet-2043	412	33	than	than	ADP
admet-2043	412	34	500	500	NUM
admet-2043	412	35	nm	nm	NOUN
admet-2043	412	36	in	in	ADP
admet-2043	412	37	diameter	diameter	NOUN
admet-2043	413	1	[	[	X
admet-2043	413	2	115	115	NUM
admet-2043	413	3	]	]	PUNCT
admet-2043	413	4	.	.	PUNCT
admet-2043	414	1	liposomes	liposome	NOUN
admet-2043	414	2	have	have	AUX
admet-2043	414	3	been	be	AUX
admet-2043	414	4	widely	widely	ADV
admet-2043	414	5	recognised	recognise	VERB
admet-2043	414	6	as	as	ADP
admet-2043	414	7	highly	highly	ADV
admet-2043	414	8	efficient	efficient	ADJ
admet-2043	414	9	delivery	delivery	NOUN
admet-2043	414	10	systems	system	NOUN
admet-2043	414	11	for	for	ADP
admet-2043	414	12	diverse	diverse	ADJ
admet-2043	414	13	therapeutic	therapeutic	ADJ
admet-2043	414	14	compounds	compound	NOUN
admet-2043	414	15	,	,	PUNCT
admet-2043	414	16	encompassing	encompass	VERB
admet-2043	414	17	drugs	drug	NOUN
admet-2043	414	18	,	,	PUNCT
admet-2043	414	19	immunisations	immunisation	NOUN
admet-2043	414	20	,	,	PUNCT
admet-2043	414	21	nucleic	nucleic	ADJ
admet-2043	414	22	acids	acid	NOUN
admet-2043	414	23	,	,	PUNCT
admet-2043	414	24	and	and	CCONJ
admet-2043	414	25	proteins	protein	NOUN
admet-2043	414	26	.	.	PUNCT
admet-2043	415	1	the	the	DET
admet-2043	415	2	surface	surface	NOUN
admet-2043	415	3	of	of	ADP
admet-2043	415	4	these	these	DET
admet-2043	415	5	entities	entity	NOUN
admet-2043	415	6	exhibits	exhibit	VERB
admet-2043	415	7	a	a	DET
admet-2043	415	8	remarkable	remarkable	ADJ
admet-2043	415	9	propensity	propensity	NOUN
admet-2043	415	10	for	for	ADP
admet-2043	415	11	facile	facile	ADJ
admet-2043	415	12	modification	modification	NOUN
admet-2043	415	13	,	,	PUNCT
admet-2043	415	14	rendering	render	VERB
admet-2043	415	15	them	they	PRON
admet-2043	415	16	highly	highly	ADV
admet-2043	415	17	amenable	amenable	ADJ
admet-2043	415	18	to	to	ADP
admet-2043	415	19	customization	customization	NOUN
admet-2043	415	20	.	.	PUNCT
admet-2043	416	1	moreover	moreover	ADV
admet-2043	416	2	,	,	PUNCT
admet-2043	416	3	their	their	PRON
admet-2043	416	4	inherent	inherent	ADJ
admet-2043	416	5	biocompatibility	biocompatibility	NOUN
admet-2043	416	6	endows	endow	VERB
admet-2043	416	7	them	they	PRON
admet-2043	416	8	with	with	ADP
admet-2043	416	9	the	the	DET
admet-2043	416	10	ability	ability	NOUN
admet-2043	416	11	to	to	PART
admet-2043	416	12	seamlessly	seamlessly	ADV
admet-2043	416	13	integrate	integrate	VERB
admet-2043	416	14	into	into	ADP
admet-2043	416	15	biological	biological	ADJ
admet-2043	416	16	systems	system	NOUN
admet-2043	416	17	.	.	PUNCT
admet-2043	417	1	notably	notably	ADV
admet-2043	417	2	,	,	PUNCT
admet-2043	417	3	these	these	DET
admet-2043	417	4	entities	entity	NOUN
admet-2043	417	5	possess	possess	VERB
admet-2043	417	6	an	an	DET
admet-2043	417	7	amphiphilic	amphiphilic	ADJ
admet-2043	417	8	nature	nature	NOUN
admet-2043	417	9	,	,	PUNCT
admet-2043	417	10	allowing	allow	VERB
admet-2043	417	11	them	they	PRON
admet-2043	417	12	to	to	PART
admet-2043	417	13	interact	interact	VERB
admet-2043	417	14	with	with	ADP
admet-2043	417	15	both	both	CCONJ
admet-2043	417	16	hydrophilic	hydrophilic	ADJ
admet-2043	417	17	and	and	CCONJ
admet-2043	417	18	hydrophobic	hydrophobic	NOUN
admet-2043	417	19	environments	environment	NOUN
admet-2043	417	20	.	.	PUNCT
admet-2043	418	1	additionally	additionally	ADV
admet-2043	418	2	,	,	PUNCT
admet-2043	418	3	their	their	PRON
admet-2043	418	4	extended	extended	ADJ
admet-2043	418	5	circulation	circulation	NOUN
admet-2043	418	6	times	time	NOUN
admet-2043	418	7	further	far	ADV
admet-2043	418	8	enhance	enhance	VERB
admet-2043	418	9	their	their	PRON
admet-2043	418	10	utility	utility	NOUN
admet-2043	418	11	and	and	CCONJ
admet-2043	418	12	potential	potential	NOUN
admet-2043	418	13	for	for	ADP
admet-2043	418	14	various	various	ADJ
admet-2043	418	15	applications	application	NOUN
admet-2043	418	16	.	.	PUNCT
admet-2043	419	1	surface	surface	NOUN
admet-2043	419	2	modification	modification	NOUN
admet-2043	419	3	techniques	technique	NOUN
admet-2043	419	4	play	play	VERB
admet-2043	419	5	a	a	DET
admet-2043	419	6	crucial	crucial	ADJ
admet-2043	419	7	role	role	NOUN
admet-2043	419	8	in	in	ADP
admet-2043	419	9	tailoring	tailor	VERB
admet-2043	419	10	the	the	DET
admet-2043	419	11	properties	property	NOUN
admet-2043	419	12	and	and	CCONJ
admet-2043	419	13	objectives	objective	NOUN
admet-2043	419	14	of	of	ADP
admet-2043	419	15	liposomes	liposome	NOUN
admet-2043	419	16	.	.	PUNCT
admet-2043	420	1	these	these	DET
admet-2043	420	2	techniques	technique	NOUN
admet-2043	420	3	encompass	encompass	VERB
admet-2043	420	4	the	the	DET
admet-2043	420	5	incorporation	incorporation	NOUN
admet-2043	420	6	of	of	ADP
admet-2043	420	7	various	various	ADJ
admet-2043	420	8	entities	entity	NOUN
admet-2043	420	9	,	,	PUNCT
admet-2043	420	10	including	include	VERB
admet-2043	420	11	polymers	polymer	NOUN
admet-2043	420	12	,	,	PUNCT
admet-2043	420	13	polysaccharides	polysaccharide	NOUN
admet-2043	420	14	,	,	PUNCT
admet-2043	420	15	peptides	peptide	NOUN
admet-2043	420	16	,	,	PUNCT
admet-2043	420	17	or	or	CCONJ
admet-2043	420	18	antibodies	antibodie	VERB
admet-2043	420	19	,	,	PUNCT
admet-2043	420	20	to	to	PART
admet-2043	420	21	achieve	achieve	VERB
admet-2043	420	22	the	the	DET
admet-2043	420	23	desired	desire	VERB
admet-2043	420	24	specifications	specification	NOUN
admet-2043	420	25	.	.	PUNCT
admet-2043	421	1	pegylation	pegylation	NOUN
admet-2043	421	2	is	be	AUX
admet-2043	421	3	a	a	DET
admet-2043	421	4	widely	widely	ADV
admet-2043	421	5	employed	employ	VERB
admet-2043	421	6	strategy	strategy	NOUN
admet-2043	421	7	in	in	ADP
admet-2043	421	8	biomedical	biomedical	ADJ
admet-2043	421	9	research	research	NOUN
admet-2043	421	10	aimed	aim	VERB
admet-2043	421	11	at	at	ADP
admet-2043	421	12	improving	improve	VERB
admet-2043	421	13	the	the	DET
admet-2043	421	14	biodistribution	biodistribution	NOUN
admet-2043	421	15	of	of	ADP
admet-2043	421	16	liposomes	liposome	NOUN
admet-2043	421	17	and	and	CCONJ
admet-2043	421	18	mitigating	mitigate	VERB
admet-2043	421	19	their	their	PRON
admet-2043	421	20	immune	immune	ADJ
admet-2043	421	21	clearance	clearance	NOUN
admet-2043	421	22	[	[	X
admet-2043	421	23	36	36	NUM
admet-2043	421	24	]	]	PUNCT
admet-2043	421	25	.	.	PUNCT
admet-2043	422	1	moreover	moreover	ADV
admet-2043	422	2	,	,	PUNCT
admet-2043	422	3	the	the	DET
admet-2043	422	4	utilisation	utilisation	NOUN
admet-2043	422	5	of	of	ADP
admet-2043	422	6	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	422	7	m.	m.	NOUN
admet-2043	422	8	kulkarni	kulkarni	PROPN
admet-2043	422	9	et	et	PROPN
admet-2043	422	10	al	al	PROPN
admet-2043	422	11	.	.	PROPN
admet-2043	422	12	admet	admet	PROPN
admet-2043	422	13	&	&	CCONJ
admet-2043	422	14	dmpk	dmpk	PROPN
admet-2043	422	15	12(1	12(1	PROPN
admet-2043	422	16	)	)	PUNCT
admet-2043	422	17	(	(	PUNCT
admet-2043	422	18	2024	2024	NUM
admet-2043	422	19	)	)	PUNCT
admet-2043	422	20	63	63	NUM
admet-2043	422	21	-	-	SYM
admet-2043	422	22	105	105	NUM
admet-2043	422	23	80	80	NUM
admet-2043	422	24	transferrin	transferrin	NOUN
admet-2043	422	25	or	or	CCONJ
admet-2043	422	26	apoe	apoe	NOUN
admet-2043	422	27	has	have	AUX
admet-2043	422	28	been	be	AUX
admet-2043	422	29	demonstrated	demonstrate	VERB
admet-2043	422	30	as	as	ADP
admet-2043	422	31	a	a	DET
admet-2043	422	32	viable	viable	ADJ
admet-2043	422	33	approach	approach	NOUN
admet-2043	422	34	for	for	ADP
admet-2043	422	35	the	the	DET
admet-2043	422	36	fabrication	fabrication	NOUN
admet-2043	422	37	of	of	ADP
admet-2043	422	38	liposomes	liposome	NOUN
admet-2043	422	39	,	,	PUNCT
admet-2043	422	40	thereby	thereby	ADV
admet-2043	422	41	facilitating	facilitate	VERB
admet-2043	422	42	the	the	DET
admet-2043	422	43	delivery	delivery	NOUN
admet-2043	422	44	of	of	ADP
admet-2043	422	45	gene	gene	NOUN
admet-2043	422	46	therapy	therapy	NOUN
admet-2043	422	47	and	and	CCONJ
admet-2043	422	48	medications	medication	NOUN
admet-2043	422	49	across	across	ADP
admet-2043	422	50	the	the	DET
admet-2043	422	51	bbb	bbb	NOUN
admet-2043	423	1	[	[	X
admet-2043	423	2	120	120	NUM
admet-2043	423	3	]	]	PUNCT
admet-2043	423	4	.	.	PUNCT
admet-2043	424	1	another	another	DET
admet-2043	424	2	approach	approach	NOUN
admet-2043	424	3	to	to	ADP
admet-2043	424	4	enabling	enable	VERB
admet-2043	424	5	liposomes	liposome	NOUN
admet-2043	424	6	to	to	PART
admet-2043	424	7	penetrate	penetrate	VERB
admet-2043	424	8	the	the	DET
admet-2043	424	9	bbb	bbb	NOUN
admet-2043	424	10	via	via	ADP
admet-2043	424	11	receptor	receptor	NOUN
admet-2043	424	12	-	-	PUNCT
admet-2043	424	13	mediated	mediate	VERB
admet-2043	424	14	transcytosis	transcytosis	NOUN
admet-2043	424	15	(	(	PUNCT
admet-2043	424	16	rmt	rmt	NOUN
admet-2043	424	17	)	)	PUNCT
admet-2043	424	18	is	be	AUX
admet-2043	424	19	to	to	PART
admet-2043	424	20	combine	combine	VERB
admet-2043	424	21	them	they	PRON
admet-2043	424	22	to	to	PART
admet-2043	424	23	target	target	VERB
admet-2043	424	24	ligands	ligand	NOUN
admet-2043	424	25	that	that	PRON
admet-2043	424	26	link	link	VERB
admet-2043	424	27	to	to	ADP
admet-2043	424	28	receptors	receptor	NOUN
admet-2043	424	29	on	on	ADP
admet-2043	424	30	the	the	DET
admet-2043	424	31	surface	surface	NOUN
admet-2043	424	32	of	of	ADP
admet-2043	424	33	brain	brain	NOUN
admet-2043	424	34	endothelial	endothelial	ADJ
admet-2043	424	35	cells	cell	NOUN
admet-2043	424	36	[	[	X
admet-2043	424	37	115	115	NUM
admet-2043	424	38	]	]	PUNCT
admet-2043	424	39	.	.	PUNCT
admet-2043	425	1	additional	additional	ADJ
admet-2043	425	2	strategies	strategy	NOUN
admet-2043	425	3	encompass	encompass	VERB
admet-2043	425	4	the	the	DET
admet-2043	425	5	modification	modification	NOUN
admet-2043	425	6	of	of	ADP
admet-2043	425	7	liposomal	liposomal	ADJ
admet-2043	425	8	surfaces	surface	NOUN
admet-2043	425	9	by	by	ADP
admet-2043	425	10	integrating	integrate	VERB
admet-2043	425	11	stealthy	stealthy	ADJ
admet-2043	425	12	polymers	polymer	NOUN
admet-2043	425	13	or	or	CCONJ
admet-2043	425	14	other	other	ADJ
admet-2043	425	15	compounds	compound	NOUN
admet-2043	425	16	,	,	PUNCT
admet-2043	425	17	thereby	thereby	ADV
admet-2043	425	18	attenuating	attenuate	VERB
admet-2043	425	19	the	the	DET
admet-2043	425	20	immunological	immunological	ADJ
admet-2043	425	21	response	response	NOUN
admet-2043	425	22	and	and	CCONJ
admet-2043	425	23	prolonging	prolong	VERB
admet-2043	425	24	their	their	PRON
admet-2043	425	25	circulation	circulation	NOUN
admet-2043	425	26	time	time	NOUN
admet-2043	425	27	within	within	ADP
admet-2043	425	28	the	the	DET
admet-2043	425	29	vascular	vascular	ADJ
admet-2043	425	30	system	system	NOUN
admet-2043	425	31	.	.	PUNCT
admet-2043	426	1	pharmaceutical	pharmaceutical	NOUN
admet-2043	426	2	compounds	compound	NOUN
admet-2043	426	3	that	that	PRON
admet-2043	426	4	exhibit	exhibit	VERB
admet-2043	426	5	responsive	responsive	ADJ
admet-2043	426	6	behaviour	behaviour	NOUN
admet-2043	426	7	in	in	ADP
admet-2043	426	8	the	the	DET
admet-2043	426	9	presence	presence	NOUN
admet-2043	426	10	of	of	ADP
admet-2043	426	11	specific	specific	ADJ
admet-2043	426	12	stimuli	stimulus	NOUN
admet-2043	426	13	,	,	PUNCT
admet-2043	426	14	such	such	ADJ
admet-2043	426	15	as	as	ADP
admet-2043	426	16	alterations	alteration	NOUN
admet-2043	426	17	in	in	ADP
admet-2043	426	18	ph	ph	NOUN
admet-2043	426	19	or	or	CCONJ
admet-2043	426	20	temperature	temperature	NOUN
admet-2043	426	21	,	,	PUNCT
admet-2043	426	22	have	have	AUX
admet-2043	426	23	been	be	AUX
admet-2043	426	24	investigated	investigate	VERB
admet-2043	426	25	for	for	ADP
admet-2043	426	26	their	their	PRON
admet-2043	426	27	potential	potential	ADJ
admet-2043	426	28	encapsulation	encapsulation	NOUN
admet-2043	426	29	within	within	ADP
admet-2043	426	30	liposomal	liposomal	ADJ
admet-2043	426	31	structures	structure	NOUN
admet-2043	426	32	.	.	PUNCT
admet-2043	427	1	this	this	DET
admet-2043	427	2	encapsulation	encapsulation	NOUN
admet-2043	427	3	strategy	strategy	NOUN
admet-2043	427	4	enables	enable	VERB
admet-2043	427	5	the	the	DET
admet-2043	427	6	controlled	control	VERB
admet-2043	427	7	and	and	CCONJ
admet-2043	427	8	triggered	trigger	VERB
admet-2043	427	9	release	release	NOUN
admet-2043	427	10	of	of	ADP
admet-2043	427	11	the	the	DET
admet-2043	427	12	therapeutic	therapeutic	ADJ
admet-2043	427	13	agent	agent	NOUN
admet-2043	427	14	at	at	ADP
admet-2043	427	15	the	the	DET
admet-2043	427	16	desired	desire	VERB
admet-2043	427	17	anatomical	anatomical	ADJ
admet-2043	427	18	site	site	NOUN
admet-2043	427	19	[	[	X
admet-2043	427	20	113	113	NUM
admet-2043	427	21	]	]	PUNCT
admet-2043	427	22	.	.	PUNCT
admet-2043	428	1	the	the	DET
admet-2043	428	2	reticuloendothelial	reticuloendothelial	ADJ
admet-2043	428	3	system	system	NOUN
admet-2043	428	4	eliminates	eliminate	VERB
admet-2043	428	5	typical	typical	ADJ
admet-2043	428	6	liposomes	liposome	NOUN
admet-2043	428	7	,	,	PUNCT
admet-2043	428	8	which	which	PRON
admet-2043	428	9	results	result	VERB
admet-2043	428	10	in	in	ADP
admet-2043	428	11	a	a	DET
admet-2043	428	12	shorter	short	ADJ
admet-2043	428	13	circulation	circulation	NOUN
admet-2043	428	14	period	period	NOUN
admet-2043	428	15	.	.	PUNCT
admet-2043	429	1	transferrin	transferrin	NOUN
admet-2043	429	2	,	,	PUNCT
admet-2043	429	3	glucose	glucose	NOUN
admet-2043	429	4	,	,	PUNCT
admet-2043	429	5	and	and	CCONJ
admet-2043	429	6	tat	tat	NOUN
admet-2043	429	7	peptide	peptide	NOUN
admet-2043	429	8	have	have	AUX
admet-2043	429	9	all	all	PRON
admet-2043	429	10	been	be	AUX
admet-2043	429	11	investigated	investigate	VERB
admet-2043	429	12	for	for	ADP
admet-2043	429	13	potential	potential	ADJ
admet-2043	429	14	surface	surface	NOUN
admet-2043	429	15	modifications	modification	NOUN
admet-2043	429	16	to	to	PART
admet-2043	429	17	improve	improve	VERB
admet-2043	429	18	the	the	DET
admet-2043	429	19	dispersion	dispersion	NOUN
admet-2043	429	20	of	of	ADP
admet-2043	429	21	loaded	load	VERB
admet-2043	429	22	liposomes	liposome	NOUN
admet-2043	429	23	in	in	ADP
admet-2043	429	24	the	the	DET
admet-2043	429	25	brain	brain	NOUN
admet-2043	429	26	.	.	PUNCT
admet-2043	430	1	however	however	ADV
admet-2043	430	2	,	,	PUNCT
admet-2043	430	3	there	there	PRON
admet-2043	430	4	is	be	VERB
admet-2043	430	5	concern	concern	NOUN
admet-2043	430	6	regarding	regard	VERB
admet-2043	430	7	the	the	DET
admet-2043	430	8	nonspecific	nonspecific	ADJ
admet-2043	430	9	delivery	delivery	NOUN
admet-2043	430	10	of	of	ADP
admet-2043	430	11	highly	highly	ADV
admet-2043	430	12	active	active	ADJ
admet-2043	430	13	drugs	drug	NOUN
admet-2043	430	14	to	to	PART
admet-2043	430	15	healthy	healthy	ADJ
admet-2043	430	16	,	,	PUNCT
admet-2043	430	17	non	non	ADJ
admet-2043	430	18	-	-	ADJ
admet-2043	430	19	cancerous	cancerous	ADJ
admet-2043	430	20	brain	brain	NOUN
admet-2043	430	21	tissues	tissue	NOUN
admet-2043	430	22	across	across	ADP
admet-2043	430	23	the	the	DET
admet-2043	430	24	bbb	bbb	NOUN
admet-2043	431	1	[	[	X
admet-2043	431	2	34	34	NUM
admet-2043	431	3	]	]	PUNCT
admet-2043	431	4	.	.	PUNCT
admet-2043	432	1	dual	dual	ADV
admet-2043	432	2	-	-	PUNCT
admet-2043	432	3	targeting	target	VERB
admet-2043	432	4	liposomal	liposomal	ADJ
admet-2043	432	5	formulations	formulation	NOUN
admet-2043	432	6	,	,	PUNCT
admet-2043	432	7	where	where	SCONJ
admet-2043	432	8	liposomes	liposome	NOUN
admet-2043	432	9	are	be	AUX
admet-2043	432	10	coupled	couple	VERB
admet-2043	432	11	with	with	ADP
admet-2043	432	12	both	both	CCONJ
admet-2043	432	13	transferrin	transferrin	NOUN
admet-2043	432	14	and	and	CCONJ
admet-2043	432	15	folate	folate	NOUN
admet-2043	432	16	,	,	PUNCT
admet-2043	432	17	have	have	AUX
admet-2043	432	18	been	be	AUX
admet-2043	432	19	created	create	VERB
admet-2043	432	20	to	to	PART
admet-2043	432	21	solve	solve	VERB
admet-2043	432	22	this	this	DET
admet-2043	432	23	problem	problem	NOUN
admet-2043	432	24	.	.	PUNCT
admet-2043	433	1	this	this	DET
admet-2043	433	2	study	study	NOUN
admet-2043	433	3	shows	show	VERB
admet-2043	433	4	the	the	DET
admet-2043	433	5	effectiveness	effectiveness	NOUN
admet-2043	433	6	of	of	ADP
admet-2043	433	7	liposomes	liposome	NOUN
admet-2043	433	8	in	in	ADP
admet-2043	433	9	their	their	PRON
admet-2043	433	10	ease	ease	NOUN
admet-2043	433	11	of	of	ADP
admet-2043	433	12	surface	surface	NOUN
admet-2043	433	13	modification	modification	NOUN
admet-2043	433	14	[	[	X
admet-2043	433	15	121	121	NUM
admet-2043	433	16	]	]	PUNCT
admet-2043	433	17	.	.	PUNCT
admet-2043	434	1	slns	slns	PROPN
admet-2043	434	2	are	be	AUX
admet-2043	434	3	a	a	DET
admet-2043	434	4	class	class	NOUN
admet-2043	434	5	of	of	ADP
admet-2043	434	6	nanocarriers	nanocarrier	NOUN
admet-2043	434	7	that	that	PRON
admet-2043	434	8	exhibit	exhibit	VERB
admet-2043	434	9	similarities	similarity	NOUN
admet-2043	434	10	to	to	ADP
admet-2043	434	11	liposomes	liposome	NOUN
admet-2043	434	12	yet	yet	ADV
admet-2043	434	13	possess	possess	VERB
admet-2043	434	14	distinct	distinct	ADJ
admet-2043	434	15	structural	structural	ADJ
admet-2043	434	16	characteristics	characteristic	NOUN
admet-2043	434	17	.	.	PUNCT
admet-2043	435	1	unlike	unlike	ADP
admet-2043	435	2	liposomes	liposome	NOUN
admet-2043	435	3	,	,	PUNCT
admet-2043	435	4	slns	slns	NOUN
admet-2043	435	5	consist	consist	NOUN
admet-2043	435	6	of	of	ADP
admet-2043	435	7	solid	solid	ADJ
admet-2043	435	8	lipid	lipid	NOUN
admet-2043	435	9	spheres	sphere	NOUN
admet-2043	435	10	,	,	PUNCT
admet-2043	435	11	wherein	wherein	SCONJ
admet-2043	435	12	the	the	DET
admet-2043	435	13	lipid	lipid	NOUN
admet-2043	435	14	matrix	matrix	NOUN
admet-2043	435	15	is	be	AUX
admet-2043	435	16	predominantly	predominantly	ADV
admet-2043	435	17	lipophilic	lipophilic	ADJ
admet-2043	435	18	rather	rather	ADV
admet-2043	435	19	than	than	ADP
admet-2043	435	20	organised	organise	VERB
admet-2043	435	21	into	into	ADP
admet-2043	435	22	a	a	DET
admet-2043	435	23	lipid	lipid	NOUN
admet-2043	435	24	bilayer	bilayer	NOUN
admet-2043	435	25	.	.	PUNCT
admet-2043	436	1	the	the	DET
admet-2043	436	2	stability	stability	NOUN
admet-2043	436	3	of	of	ADP
admet-2043	436	4	solid	solid	ADJ
admet-2043	436	5	lipid	lipid	NOUN
admet-2043	436	6	nanoparticles	nanoparticle	NOUN
admet-2043	436	7	(	(	PUNCT
admet-2043	436	8	slns	slns	NOUN
admet-2043	436	9	)	)	PUNCT
admet-2043	436	10	surpasses	surpass	VERB
admet-2043	436	11	that	that	PRON
admet-2043	436	12	of	of	ADP
admet-2043	436	13	liposomes	liposome	NOUN
admet-2043	436	14	,	,	PUNCT
admet-2043	436	15	rendering	render	VERB
admet-2043	436	16	them	they	PRON
admet-2043	436	17	a	a	DET
admet-2043	436	18	more	more	ADV
admet-2043	436	19	favourable	favourable	ADJ
admet-2043	436	20	option	option	NOUN
admet-2043	436	21	in	in	ADP
admet-2043	436	22	drug	drug	NOUN
admet-2043	436	23	delivery	delivery	NOUN
admet-2043	436	24	systems	system	NOUN
admet-2043	436	25	.	.	PUNCT
admet-2043	437	1	additionally	additionally	ADV
admet-2043	437	2	,	,	PUNCT
admet-2043	437	3	the	the	DET
admet-2043	437	4	manufacturing	manufacturing	NOUN
admet-2043	437	5	process	process	NOUN
admet-2043	437	6	of	of	ADP
admet-2043	437	7	slns	slns	NOUN
admet-2043	437	8	is	be	AUX
admet-2043	437	9	characterised	characterise	VERB
admet-2043	437	10	by	by	ADP
admet-2043	437	11	enhanced	enhanced	ADJ
admet-2043	437	12	efficiency	efficiency	NOUN
admet-2043	437	13	,	,	PUNCT
admet-2043	437	14	allowing	allow	VERB
admet-2043	437	15	for	for	ADP
admet-2043	437	16	rapid	rapid	ADJ
admet-2043	437	17	production	production	NOUN
admet-2043	437	18	compared	compare	VERB
admet-2043	437	19	to	to	ADP
admet-2043	437	20	liposomes	liposome	NOUN
admet-2043	437	21	.	.	PUNCT
admet-2043	438	1	moreover	moreover	ADV
admet-2043	438	2	,	,	PUNCT
admet-2043	438	3	slns	slns	PROPN
admet-2043	438	4	exhibit	exhibit	PROPN
admet-2043	438	5	superior	superior	ADJ
admet-2043	438	6	efficacy	efficacy	NOUN
admet-2043	438	7	in	in	ADP
admet-2043	438	8	facilitating	facilitate	VERB
admet-2043	438	9	the	the	DET
admet-2043	438	10	transportation	transportation	NOUN
admet-2043	438	11	of	of	ADP
admet-2043	438	12	drugs	drug	NOUN
admet-2043	438	13	,	,	PUNCT
admet-2043	438	14	thereby	thereby	ADV
admet-2043	438	15	enhancing	enhance	VERB
admet-2043	438	16	their	their	PRON
admet-2043	438	17	therapeutic	therapeutic	ADJ
admet-2043	438	18	potential	potential	NOUN
admet-2043	438	19	.	.	PUNCT
admet-2043	439	1	extensive	extensive	ADJ
admet-2043	439	2	research	research	NOUN
admet-2043	439	3	has	have	AUX
admet-2043	439	4	been	be	AUX
admet-2043	439	5	conducted	conduct	VERB
admet-2043	439	6	on	on	ADP
admet-2043	439	7	the	the	DET
admet-2043	439	8	utilisation	utilisation	NOUN
admet-2043	439	9	of	of	ADP
admet-2043	439	10	liposomes	liposome	NOUN
admet-2043	439	11	and	and	CCONJ
admet-2043	439	12	slns	slns	NOUN
admet-2043	439	13	as	as	ADP
admet-2043	439	14	potential	potential	ADJ
admet-2043	439	15	strategies	strategy	NOUN
admet-2043	439	16	for	for	ADP
admet-2043	439	17	traversing	traverse	VERB
admet-2043	439	18	the	the	DET
admet-2043	439	19	bbb	bbb	NOUN
admet-2043	439	20	in	in	ADP
admet-2043	439	21	the	the	DET
admet-2043	439	22	context	context	NOUN
admet-2043	439	23	of	of	ADP
admet-2043	439	24	brain	brain	NOUN
admet-2043	439	25	tumour	tumour	NOUN
admet-2043	439	26	treatment	treatment	NOUN
admet-2043	439	27	[	[	X
admet-2043	439	28	122	122	NUM
admet-2043	439	29	,	,	PUNCT
admet-2043	439	30	123	123	NUM
admet-2043	439	31	]	]	PUNCT
admet-2043	439	32	.	.	PUNCT
admet-2043	440	1	an	an	DET
admet-2043	440	2	approved	approve	VERB
admet-2043	440	3	drug	drug	NOUN
admet-2043	440	4	called	call	VERB
admet-2043	440	5	liposomal	liposomal	ADJ
admet-2043	440	6	doxorubicin	doxorubicin	PROPN
admet-2043	440	7	is	be	AUX
admet-2043	440	8	used	use	VERB
admet-2043	440	9	to	to	PART
admet-2043	440	10	treat	treat	VERB
admet-2043	440	11	a	a	DET
admet-2043	440	12	number	number	NOUN
admet-2043	440	13	of	of	ADP
admet-2043	440	14	neoplasms	neoplasm	NOUN
admet-2043	440	15	,	,	PUNCT
admet-2043	440	16	including	include	VERB
admet-2043	440	17	brain	brain	NOUN
admet-2043	440	18	tumours	tumour	NOUN
admet-2043	441	1	[	[	X
admet-2043	441	2	124	124	NUM
admet-2043	441	3	]	]	PUNCT
admet-2043	441	4	.	.	PUNCT
admet-2043	442	1	it	it	PRON
admet-2043	442	2	is	be	AUX
admet-2043	442	3	possible	possible	ADJ
admet-2043	442	4	that	that	SCONJ
admet-2043	442	5	fus	fus	PROPN
admet-2043	442	6	will	will	AUX
admet-2043	442	7	produce	produce	VERB
admet-2043	442	8	better	well	ADJ
admet-2043	442	9	liposomes	liposome	NOUN
admet-2043	442	10	that	that	PRON
admet-2043	442	11	deliver	deliver	VERB
admet-2043	442	12	medications	medication	NOUN
admet-2043	442	13	.	.	PUNCT
admet-2043	443	1	,	,	PUNCT
admet-2043	443	2	such	such	ADJ
admet-2043	443	3	as	as	ADP
admet-2043	443	4	cisplatin	cisplatin	NOUN
admet-2043	443	5	or	or	CCONJ
admet-2043	443	6	doxorubicin	doxorubicin	PROPN
admet-2043	443	7	,	,	PUNCT
admet-2043	443	8	to	to	PART
admet-2043	443	9	increase	increase	VERB
admet-2043	443	10	bbb	bbb	NOUN
admet-2043	443	11	permeability	permeability	NOUN
admet-2043	443	12	and	and	CCONJ
admet-2043	443	13	decrease	decrease	VERB
admet-2043	443	14	tumour	tumour	ADJ
admet-2043	443	15	growth	growth	NOUN
admet-2043	443	16	in	in	ADP
admet-2043	443	17	mice	mouse	NOUN
admet-2043	443	18	.	.	PUNCT
admet-2043	444	1	fus	fus	PROPN
admet-2043	444	2	enhances	enhance	VERB
admet-2043	444	3	the	the	DET
admet-2043	444	4	relative	relative	ADJ
admet-2043	444	5	permeability	permeability	NOUN
admet-2043	444	6	of	of	ADP
admet-2043	444	7	the	the	DET
admet-2043	444	8	bbb	bbb	NOUN
admet-2043	444	9	in	in	ADP
admet-2043	444	10	a	a	DET
admet-2043	444	11	time	time	NOUN
admet-2043	444	12	-	-	PUNCT
admet-2043	444	13	dependent	dependent	ADJ
admet-2043	444	14	manner	manner	NOUN
admet-2043	444	15	:	:	PUNCT
admet-2043	444	16	an	an	DET
admet-2043	444	17	experimental	experimental	ADJ
admet-2043	444	18	study	study	NOUN
admet-2043	444	19	"	"	PUNCT
admet-2043	444	20	by	by	ADP
admet-2043	444	21	yufeng	yufeng	PROPN
admet-2043	444	22	zhou	zhou	PROPN
admet-2043	444	23	et	et	PROPN
admet-2043	444	24	al	al	PROPN
admet-2043	444	25	.	.	PUNCT
admet-2043	445	1	[	[	X
admet-2043	445	2	125	125	NUM
admet-2043	445	3	]	]	PUNCT
admet-2043	445	4	.	.	PUNCT
admet-2043	446	1	rat	rat	NOUN
admet-2043	446	2	glioma	glioma	NOUN
admet-2043	446	3	tumours	tumour	NOUN
admet-2043	446	4	can	can	AUX
admet-2043	446	5	be	be	AUX
admet-2043	446	6	targeted	target	VERB
admet-2043	446	7	with	with	ADP
admet-2043	446	8	paclitaxel	paclitaxel	NOUN
admet-2043	446	9	-	-	PUNCT
admet-2043	446	10	carrying	carry	VERB
admet-2043	446	11	liposomes	liposome	NOUN
admet-2043	446	12	that	that	PRON
admet-2043	446	13	can	can	AUX
admet-2043	446	14	pass	pass	VERB
admet-2043	446	15	through	through	ADP
admet-2043	446	16	the	the	DET
admet-2043	446	17	bbb	bbb	PROPN
admet-2043	446	18	.	.	PUNCT
admet-2043	447	1	it	it	PRON
admet-2043	447	2	is	be	AUX
admet-2043	447	3	possible	possible	ADJ
admet-2043	447	4	to	to	PART
admet-2043	447	5	enhance	enhance	VERB
admet-2043	447	6	the	the	DET
admet-2043	447	7	ability	ability	NOUN
admet-2043	447	8	of	of	ADP
admet-2043	447	9	drug	drug	NOUN
admet-2043	447	10	-	-	PUNCT
admet-2043	447	11	loaded	load	VERB
admet-2043	447	12	liposomes	liposome	NOUN
admet-2043	447	13	to	to	PART
admet-2043	447	14	target	target	VERB
admet-2043	447	15	gliomas	glioma	NOUN
admet-2043	447	16	and	and	CCONJ
admet-2043	447	17	increase	increase	VERB
admet-2043	447	18	animal	animal	NOUN
admet-2043	447	19	models	model	NOUN
admet-2043	447	20	'	'	PART
admet-2043	447	21	lifespans	lifespan	NOUN
admet-2043	447	22	by	by	ADP
admet-2043	447	23	conjugating	conjugate	VERB
admet-2043	447	24	them	they	PRON
admet-2043	447	25	with	with	ADP
admet-2043	447	26	particular	particular	ADJ
admet-2043	447	27	vectors	vector	NOUN
admet-2043	447	28	[	[	X
admet-2043	447	29	105	105	NUM
admet-2043	447	30	]	]	PUNCT
admet-2043	447	31	.	.	PUNCT
admet-2043	448	1	carbon	carbon	NOUN
admet-2043	448	2	nanotubes	nanotube	NOUN
admet-2043	448	3	due	due	ADP
admet-2043	448	4	to	to	ADP
admet-2043	448	5	their	their	PRON
admet-2043	448	6	special	special	ADJ
admet-2043	448	7	characteristics	characteristic	NOUN
admet-2043	448	8	,	,	PUNCT
admet-2043	448	9	carbon	carbon	NOUN
admet-2043	448	10	nanotubes	nanotube	NOUN
admet-2043	448	11	(	(	PUNCT
admet-2043	448	12	cnt	cnt	X
admet-2043	448	13	)	)	PUNCT
admet-2043	448	14	are	be	AUX
admet-2043	448	15	promising	promise	VERB
admet-2043	448	16	candidates	candidate	NOUN
admet-2043	448	17	for	for	ADP
admet-2043	448	18	medication	medication	NOUN
admet-2043	448	19	delivery	delivery	NOUN
admet-2043	448	20	in	in	ADP
admet-2043	448	21	the	the	DET
admet-2043	448	22	cns	cns	NOUN
admet-2043	448	23	.	.	PUNCT
admet-2043	449	1	the	the	DET
admet-2043	449	2	flexibility	flexibility	NOUN
admet-2043	449	3	of	of	ADP
admet-2043	449	4	the	the	DET
admet-2043	449	5	carrier	carrier	NOUN
admet-2043	449	6	can	can	AUX
admet-2043	449	7	be	be	AUX
admet-2043	449	8	influenced	influence	VERB
admet-2043	449	9	by	by	ADP
admet-2043	449	10	the	the	DET
admet-2043	449	11	number	number	NOUN
admet-2043	449	12	of	of	ADP
admet-2043	449	13	graphene	graphene	ADJ
admet-2043	449	14	layers	layer	NOUN
admet-2043	449	15	,	,	PUNCT
admet-2043	449	16	with	with	ADP
admet-2043	449	17	fewer	few	ADJ
admet-2043	449	18	layers	layer	NOUN
admet-2043	449	19	allowing	allow	VERB
admet-2043	449	20	for	for	ADP
admet-2043	449	21	more	more	ADJ
admet-2043	449	22	flexibility	flexibility	NOUN
admet-2043	449	23	[	[	X
admet-2043	449	24	126	126	NUM
admet-2043	449	25	]	]	PUNCT
admet-2043	449	26	.	.	PUNCT
admet-2043	450	1	multi	multi	ADJ
admet-2043	450	2	-	-	ADJ
admet-2043	450	3	walled	walled	ADJ
admet-2043	450	4	carbon	carbon	NOUN
admet-2043	450	5	nanotubes	nanotube	NOUN
admet-2043	450	6	functionalized	functionalize	VERB
admet-2043	450	7	with	with	ADP
admet-2043	450	8	an	an	DET
admet-2043	450	9	amine	amine	ADJ
admet-2043	450	10	group	group	NOUN
admet-2043	450	11	(	(	PUNCT
admet-2043	450	12	mwcnts	mwcnt	NOUN
admet-2043	450	13	-	-	PUNCT
admet-2043	450	14	nh3	nh3	NOUN
admet-2043	450	15	+	+	NOUN
admet-2043	450	16	)	)	PUNCT
admet-2043	450	17	have	have	AUX
admet-2043	450	18	been	be	AUX
admet-2043	450	19	shown	show	VERB
admet-2043	450	20	to	to	PART
admet-2043	450	21	successfully	successfully	ADV
admet-2043	450	22	pass	pass	VERB
admet-2043	450	23	the	the	DET
admet-2043	450	24	bbb	bbb	NOUN
admet-2043	450	25	by	by	ADP
admet-2043	450	26	transcytosis	transcytosis	NOUN
admet-2043	450	27	in	in	ADP
admet-2043	450	28	both	both	CCONJ
admet-2043	450	29	in	in	ADP
admet-2043	450	30	vitro	vitro	X
admet-2043	450	31	and	and	CCONJ
admet-2043	450	32	in	in	ADP
admet-2043	450	33	vivo	vivo	ADJ
admet-2043	450	34	rodent	rodent	NOUN
admet-2043	450	35	models	model	NOUN
admet-2043	450	36	[	[	X
admet-2043	450	37	127	127	NUM
admet-2043	450	38	]	]	PUNCT
admet-2043	450	39	.	.	PUNCT
admet-2043	451	1	these	these	DET
admet-2043	451	2	findings	finding	NOUN
admet-2043	451	3	imply	imply	VERB
admet-2043	451	4	that	that	SCONJ
admet-2043	451	5	functionalized	functionalized	ADJ
admet-2043	451	6	carbon	carbon	NOUN
admet-2043	451	7	nanotubes	nanotube	NOUN
admet-2043	451	8	may	may	AUX
admet-2043	451	9	represent	represent	VERB
admet-2043	451	10	a	a	DET
admet-2043	451	11	therapeutic	therapeutic	ADJ
admet-2043	451	12	alternative	alternative	NOUN
admet-2043	451	13	for	for	ADP
admet-2043	451	14	cns	cns	NOUN
admet-2043	451	15	conditions	condition	NOUN
admet-2043	451	16	that	that	PRON
admet-2043	451	17	call	call	VERB
admet-2043	451	18	for	for	ADP
admet-2043	451	19	effective	effective	ADJ
admet-2043	451	20	medication	medication	NOUN
admet-2043	451	21	transport	transport	NOUN
admet-2043	451	22	to	to	ADP
admet-2043	451	23	the	the	DET
admet-2043	451	24	brain	brain	NOUN
admet-2043	451	25	,	,	PUNCT
admet-2043	451	26	such	such	ADJ
admet-2043	451	27	as	as	ADP
admet-2043	451	28	brain	brain	NOUN
admet-2043	451	29	tumours	tumour	NOUN
admet-2043	452	1	[	[	X
admet-2043	452	2	128	128	NUM
admet-2043	452	3	]	]	PUNCT
admet-2043	452	4	.	.	PUNCT
admet-2043	453	1	admet	admet	PROPN
admet-2043	453	2	&	&	CCONJ
admet-2043	453	3	dmpk	dmpk	PROPN
admet-2043	453	4	12(1	12(1	PROPN
admet-2043	453	5	)	)	PUNCT
admet-2043	453	6	(	(	PUNCT
admet-2043	453	7	2024	2024	NUM
admet-2043	453	8	)	)	PUNCT
admet-2043	453	9	63	63	NUM
admet-2043	453	10	-	-	SYM
admet-2043	453	11	105	105	NUM
admet-2043	453	12	nanomaterials	nanomaterial	NOUN
admet-2043	453	13	as	as	ADP
admet-2043	453	14	drug	drug	NOUN
admet-2043	453	15	delivery	delivery	NOUN
admet-2043	453	16	agents	agent	NOUN
admet-2043	453	17	for	for	ADP
admet-2043	453	18	overcoming	overcome	VERB
admet-2043	453	19	bbb	bbb	PROPN
admet-2043	453	20	doi	doi	NOUN
admet-2043	453	21	:	:	PUNCT
admet-2043	453	22	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	453	23	81	81	NUM
admet-2043	453	24	with	with	ADP
admet-2043	453	25	some	some	DET
admet-2043	453	26	chemical	chemical	ADJ
admet-2043	453	27	substances	substance	NOUN
admet-2043	453	28	,	,	PUNCT
admet-2043	453	29	cnts	cnt	NOUN
admet-2043	453	30	can	can	AUX
admet-2043	453	31	easily	easily	ADV
admet-2043	453	32	undergo	undergo	VERB
admet-2043	453	33	surface	surface	NOUN
admet-2043	453	34	functionalization	functionalization	NOUN
admet-2043	453	35	,	,	PUNCT
admet-2043	453	36	which	which	PRON
admet-2043	453	37	may	may	AUX
admet-2043	453	38	explain	explain	VERB
admet-2043	453	39	some	some	PRON
admet-2043	453	40	of	of	ADP
admet-2043	453	41	the	the	DET
admet-2043	453	42	variance	variance	NOUN
admet-2043	453	43	in	in	ADP
admet-2043	453	44	their	their	PRON
admet-2043	453	45	physical	physical	ADJ
admet-2043	453	46	and	and	CCONJ
admet-2043	453	47	biological	biological	ADJ
admet-2043	453	48	characteristics	characteristic	NOUN
admet-2043	453	49	.	.	PUNCT
admet-2043	454	1	however	however	ADV
admet-2043	454	2	,	,	PUNCT
admet-2043	454	3	there	there	PRON
admet-2043	454	4	are	be	VERB
admet-2043	454	5	drawbacks	drawback	NOUN
admet-2043	454	6	,	,	PUNCT
admet-2043	454	7	including	include	VERB
admet-2043	454	8	toxicity	toxicity	NOUN
admet-2043	454	9	,	,	PUNCT
admet-2043	454	10	batch	batch	NOUN
admet-2043	454	11	-	-	PUNCT
admet-2043	454	12	to	to	ADP
admet-2043	454	13	-	-	PUNCT
admet-2043	454	14	batch	batch	NOUN
admet-2043	454	15	fluctuation	fluctuation	NOUN
admet-2043	454	16	,	,	PUNCT
admet-2043	454	17	and	and	CCONJ
admet-2043	454	18	high	high	ADJ
admet-2043	454	19	production	production	NOUN
admet-2043	454	20	costs	cost	NOUN
admet-2043	454	21	[	[	X
admet-2043	454	22	111	111	NUM
admet-2043	454	23	]	]	PUNCT
admet-2043	454	24	.	.	PUNCT
admet-2043	455	1	in	in	ADP
admet-2043	455	2	a	a	DET
admet-2043	455	3	study	study	NOUN
admet-2043	455	4	,	,	PUNCT
admet-2043	455	5	mwcnts	mwcnt	NOUN
admet-2043	455	6	,	,	PUNCT
admet-2043	455	7	which	which	PRON
admet-2043	455	8	,	,	PUNCT
admet-2043	455	9	to	to	PART
admet-2043	455	10	improve	improve	VERB
admet-2043	455	11	their	their	PRON
admet-2043	455	12	bioavailability	bioavailability	NOUN
admet-2043	455	13	,	,	PUNCT
admet-2043	455	14	were	be	AUX
admet-2043	455	15	additionally	additionally	ADV
admet-2043	455	16	surface	surface	NOUN
admet-2043	455	17	modified	modify	VERB
admet-2043	455	18	with	with	ADP
admet-2043	455	19	phospholipids	phospholipid	NOUN
admet-2043	455	20	and	and	CCONJ
admet-2043	455	21	polysorbate	polysorbate	NOUN
admet-2043	455	22	.	.	PROPN
admet-2043	456	1	,	,	PUNCT
admet-2043	456	2	were	be	AUX
admet-2043	456	3	exposed	expose	VERB
admet-2043	456	4	to	to	ADP
admet-2043	456	5	berberine	berberine	NOUN
admet-2043	456	6	,	,	PUNCT
admet-2043	456	7	an	an	DET
admet-2043	456	8	anti	anti	ADJ
admet-2043	456	9	-	-	ADJ
admet-2043	456	10	alzheimer	alzheimer	ADJ
admet-2043	456	11	's	's	PART
admet-2043	456	12	medication	medication	NOUN
admet-2043	456	13	.	.	PUNCT
admet-2043	457	1	shsy-5y	shsy-5y	PUNCT
admet-2043	458	1	cells	cell	NOUN
admet-2043	458	2	,	,	PUNCT
admet-2043	458	3	a	a	DET
admet-2043	458	4	triple	triple	ADJ
admet-2043	458	5	-	-	PUNCT
admet-2043	458	6	subcloned	subclone	VERB
admet-2043	458	7	cell	cell	NOUN
admet-2043	458	8	line	line	NOUN
admet-2043	458	9	generated	generate	VERB
admet-2043	458	10	from	from	ADP
admet-2043	458	11	the	the	DET
admet-2043	458	12	sk	sk	VERB
admet-2043	458	13	-	-	PUNCT
admet-2043	458	14	n	n	CCONJ
admet-2043	458	15	-	-	PUNCT
admet-2043	458	16	sh	sh	NOUN
admet-2043	458	17	neuroblastoma	neuroblastoma	ADJ
admet-2043	458	18	cell	cell	NOUN
admet-2043	458	19	line	line	NOUN
admet-2043	458	20	,	,	PUNCT
admet-2043	458	21	performed	perform	VERB
admet-2043	458	22	in	in	ADP
admet-2043	458	23	vitro	vitro	X
admet-2043	458	24	experiments	experiment	NOUN
admet-2043	458	25	,	,	PUNCT
admet-2043	458	26	and	and	CCONJ
admet-2043	458	27	the	the	DET
admet-2043	458	28	results	result	NOUN
admet-2043	458	29	showed	show	VERB
admet-2043	458	30	no	no	DET
admet-2043	458	31	detectable	detectable	ADJ
admet-2043	458	32	toxicity	toxicity	NOUN
admet-2043	458	33	.	.	PUNCT
admet-2043	459	1	rats	rat	NOUN
admet-2043	459	2	'	'	PART
admet-2043	459	3	memory	memory	NOUN
admet-2043	459	4	improved	improve	VERB
admet-2043	459	5	in	in	ADP
admet-2043	459	6	vivo	vivo	ADJ
admet-2043	459	7	tests	test	NOUN
admet-2043	459	8	after	after	SCONJ
admet-2043	459	9	the	the	DET
admet-2043	459	10	nanoformulation	nanoformulation	NOUN
admet-2043	459	11	was	be	AUX
admet-2043	459	12	given	give	VERB
admet-2043	459	13	to	to	ADP
admet-2043	459	14	them	they	PRON
admet-2043	459	15	.	.	PUNCT
admet-2043	460	1	rat	rat	NOUN
admet-2043	460	2	brain	brain	NOUN
admet-2043	460	3	and	and	CCONJ
admet-2043	460	4	plasma	plasma	NOUN
admet-2043	460	5	tissues	tissue	NOUN
admet-2043	460	6	displayed	display	VERB
admet-2043	460	7	drug	drug	NOUN
admet-2043	460	8	absorption	absorption	NOUN
admet-2043	460	9	,	,	PUNCT
admet-2043	460	10	demonstrating	demonstrate	VERB
admet-2043	460	11	bbb	bbb	PROPN
admet-2043	460	12	crossing	crossing	NOUN
admet-2043	460	13	by	by	ADP
admet-2043	460	14	the	the	DET
admet-2043	460	15	nanoformulation	nanoformulation	NOUN
admet-2043	461	1	[	[	X
admet-2043	461	2	129	129	NUM
admet-2043	461	3	]	]	PUNCT
admet-2043	461	4	.	.	PUNCT
admet-2043	462	1	consequently	consequently	ADV
admet-2043	462	2	,	,	PUNCT
admet-2043	462	3	drug	drug	NOUN
admet-2043	462	4	-	-	PUNCT
admet-2043	462	5	loaded	load	VERB
admet-2043	462	6	phospholipid	phospholipid	NOUN
admet-2043	462	7	/	/	SYM
admet-2043	462	8	polysorbate	polysorbate	NOUN
admet-2043	462	9	-	-	PUNCT
admet-2043	462	10	coated	coat	VERB
admet-2043	462	11	mwcnts	mwcnt	NOUN
admet-2043	462	12	may	may	AUX
admet-2043	462	13	aid	aid	VERB
admet-2043	462	14	ad	ad	NOUN
admet-2043	462	15	patients	patient	NOUN
admet-2043	462	16	in	in	ADP
admet-2043	462	17	reducing	reduce	VERB
admet-2043	462	18	amyloid	amyloid	NOUN
admet-2043	462	19	accumulation	accumulation	NOUN
admet-2043	462	20	at	at	ADP
admet-2043	462	21	the	the	DET
admet-2043	462	22	target	target	NOUN
admet-2043	462	23	region	region	NOUN
admet-2043	462	24	.	.	PUNCT
admet-2043	463	1	these	these	DET
admet-2043	463	2	nanostructures	nanostructure	NOUN
admet-2043	463	3	'	'	PART
admet-2043	463	4	permeability	permeability	NOUN
admet-2043	463	5	to	to	ADP
admet-2043	463	6	the	the	DET
admet-2043	463	7	brain	brain	NOUN
admet-2043	463	8	decreased	decrease	VERB
admet-2043	463	9	as	as	SCONJ
admet-2043	463	10	the	the	DET
admet-2043	463	11	temperature	temperature	NOUN
admet-2043	463	12	increased	increase	VERB
admet-2043	463	13	,	,	PUNCT
admet-2043	463	14	demonstrating	demonstrate	VERB
admet-2043	463	15	the	the	DET
admet-2043	463	16	energy	energy	NOUN
admet-2043	463	17	-	-	PUNCT
admet-2043	463	18	dependent	dependent	ADJ
admet-2043	463	19	mechanism	mechanism	NOUN
admet-2043	463	20	of	of	ADP
admet-2043	463	21	these	these	DET
admet-2043	463	22	drug	drug	NOUN
admet-2043	463	23	delivery	delivery	NOUN
admet-2043	463	24	systems	system	NOUN
admet-2043	463	25	.	.	PUNCT
admet-2043	464	1	however	however	ADV
admet-2043	464	2	,	,	PUNCT
admet-2043	464	3	significant	significant	ADJ
admet-2043	464	4	absorption	absorption	NOUN
admet-2043	464	5	by	by	ADP
admet-2043	464	6	astrocytes	astrocyte	NOUN
admet-2043	464	7	and	and	CCONJ
admet-2043	464	8	considerable	considerable	ADJ
admet-2043	464	9	accumulation	accumulation	NOUN
admet-2043	464	10	of	of	ADP
admet-2043	464	11	amino	amino	NOUN
admet-2043	464	12	-	-	PUNCT
admet-2043	464	13	functioned	function	VERB
admet-2043	464	14	single	single	ADJ
admet-2043	464	15	-	-	PUNCT
admet-2043	464	16	walled	wall	VERB
admet-2043	464	17	cnts	cnt	NOUN
admet-2043	464	18	in	in	ADP
admet-2043	464	19	brain	brain	NOUN
admet-2043	464	20	tissue	tissue	NOUN
admet-2043	464	21	were	be	AUX
admet-2043	464	22	noted	note	VERB
admet-2043	464	23	,	,	PUNCT
admet-2043	464	24	suggesting	suggest	VERB
admet-2043	464	25	these	these	DET
admet-2043	464	26	cnts	cnt	NOUN
admet-2043	464	27	could	could	AUX
admet-2043	464	28	serve	serve	VERB
admet-2043	464	29	as	as	ADP
admet-2043	464	30	cns	cns	PROPN
admet-2043	464	31	drug	drug	NOUN
admet-2043	464	32	delivery	delivery	NOUN
admet-2043	464	33	vehicles	vehicle	NOUN
admet-2043	464	34	[	[	X
admet-2043	464	35	127	127	NUM
admet-2043	464	36	]	]	PUNCT
admet-2043	464	37	.	.	PUNCT
admet-2043	465	1	to	to	PART
admet-2043	465	2	comprehend	comprehend	VERB
admet-2043	465	3	their	their	PRON
admet-2043	465	4	processses	processse	NOUN
admet-2043	465	5	of	of	ADP
admet-2043	465	6	action	action	NOUN
admet-2043	465	7	and	and	CCONJ
admet-2043	465	8	improve	improve	VERB
admet-2043	465	9	their	their	PRON
admet-2043	465	10	characteristics	characteristic	NOUN
admet-2043	465	11	for	for	ADP
admet-2043	465	12	therapeutic	therapeutic	ADJ
admet-2043	465	13	application	application	NOUN
admet-2043	465	14	,	,	PUNCT
admet-2043	465	15	more	more	ADJ
admet-2043	465	16	study	study	NOUN
admet-2043	465	17	is	be	AUX
admet-2043	465	18	necessary	necessary	ADJ
admet-2043	465	19	[	[	X
admet-2043	465	20	130	130	NUM
admet-2043	465	21	]	]	PUNCT
admet-2043	465	22	.	.	PUNCT
admet-2043	466	1	conclusively	conclusively	ADV
admet-2043	466	2	,	,	PUNCT
admet-2043	466	3	the	the	DET
admet-2043	466	4	polymeric	polymeric	ADJ
admet-2043	466	5	nanoparticles	nanoparticle	NOUN
admet-2043	466	6	hold	hold	VERB
admet-2043	466	7	great	great	ADJ
admet-2043	466	8	promise	promise	NOUN
admet-2043	466	9	in	in	ADP
admet-2043	466	10	drug	drug	NOUN
admet-2043	466	11	administration	administration	NOUN
admet-2043	466	12	due	due	ADP
admet-2043	466	13	to	to	ADP
admet-2043	466	14	their	their	PRON
admet-2043	466	15	coreshell	coreshell	NOUN
admet-2043	466	16	structure	structure	NOUN
admet-2043	466	17	and	and	CCONJ
admet-2043	466	18	hydrophilic	hydrophilic	ADJ
admet-2043	466	19	polymer	polymer	NOUN
admet-2043	466	20	coating	coating	NOUN
admet-2043	466	21	.	.	PUNCT
admet-2043	467	1	however	however	ADV
admet-2043	467	2	,	,	PUNCT
admet-2043	467	3	challenges	challenge	NOUN
admet-2043	467	4	such	such	ADJ
admet-2043	467	5	as	as	ADP
admet-2043	467	6	suboptimal	suboptimal	ADJ
admet-2043	467	7	drug	drug	NOUN
admet-2043	467	8	loading	loading	NOUN
admet-2043	467	9	capacity	capacity	NOUN
admet-2043	467	10	and	and	CCONJ
admet-2043	467	11	particle	particle	NOUN
admet-2043	467	12	aggregation	aggregation	NOUN
admet-2043	467	13	necessitate	necessitate	ADJ
admet-2043	467	14	further	further	ADJ
admet-2043	467	15	optimization	optimization	NOUN
admet-2043	467	16	.	.	PUNCT
admet-2043	468	1	strategies	strategy	NOUN
admet-2043	468	2	like	like	ADP
admet-2043	468	3	surface	surface	NOUN
admet-2043	468	4	modifications	modification	NOUN
admet-2043	468	5	with	with	ADP
admet-2043	468	6	ligands	ligand	NOUN
admet-2043	468	7	and	and	CCONJ
admet-2043	468	8	combination	combination	NOUN
admet-2043	468	9	therapies	therapy	NOUN
admet-2043	468	10	are	be	AUX
admet-2043	468	11	explored	explore	VERB
admet-2043	468	12	to	to	PART
admet-2043	468	13	enhance	enhance	VERB
admet-2043	468	14	brain	brain	NOUN
admet-2043	468	15	-	-	PUNCT
admet-2043	468	16	specific	specific	ADJ
admet-2043	468	17	drug	drug	NOUN
admet-2043	468	18	delivery	delivery	NOUN
admet-2043	468	19	and	and	CCONJ
admet-2043	468	20	efficacy	efficacy	NOUN
admet-2043	468	21	,	,	PUNCT
admet-2043	468	22	particularly	particularly	ADV
admet-2043	468	23	in	in	ADP
admet-2043	468	24	diseases	disease	NOUN
admet-2043	468	25	like	like	ADP
admet-2043	468	26	alzheimer	alzheimer	PROPN
admet-2043	468	27	's	's	PART
admet-2043	468	28	and	and	CCONJ
admet-2043	468	29	glioblastoma	glioblastoma	NOUN
admet-2043	468	30	.	.	PUNCT
admet-2043	469	1	similarly	similarly	ADV
admet-2043	469	2	,	,	PUNCT
admet-2043	469	3	the	the	DET
admet-2043	469	4	highly	highly	ADV
admet-2043	469	5	branched	branched	ADJ
admet-2043	469	6	polymers	polymer	NOUN
admet-2043	469	7	'	'	PART
admet-2043	469	8	dendrimers	dendrimer	NOUN
admet-2043	469	9	exhibit	exhibit	VERB
admet-2043	469	10	advantages	advantage	NOUN
admet-2043	469	11	such	such	ADJ
admet-2043	469	12	as	as	ADP
admet-2043	469	13	high	high	ADJ
admet-2043	469	14	loading	loading	NOUN
admet-2043	469	15	capacity	capacity	NOUN
admet-2043	469	16	and	and	CCONJ
admet-2043	469	17	precise	precise	ADJ
admet-2043	469	18	surface	surface	NOUN
admet-2043	469	19	modifications	modification	NOUN
admet-2043	469	20	.	.	PUNCT
admet-2043	470	1	their	their	PRON
admet-2043	470	2	potential	potential	NOUN
admet-2043	470	3	in	in	ADP
admet-2043	470	4	drug	drug	NOUN
admet-2043	470	5	delivery	delivery	NOUN
admet-2043	470	6	across	across	ADP
admet-2043	470	7	the	the	DET
admet-2043	470	8	bbb	bbb	PROPN
admet-2043	470	9	is	be	AUX
admet-2043	470	10	acknowledged	acknowledge	VERB
admet-2043	470	11	,	,	PUNCT
admet-2043	470	12	but	but	CCONJ
admet-2043	470	13	concerns	concern	NOUN
admet-2043	470	14	about	about	ADP
admet-2043	470	15	batch	batch	NOUN
admet-2043	470	16	variability	variability	NOUN
admet-2043	470	17	and	and	CCONJ
admet-2043	470	18	potential	potential	ADJ
admet-2043	470	19	toxicity	toxicity	NOUN
admet-2043	470	20	underline	underline	NOUN
admet-2043	470	21	the	the	DET
admet-2043	470	22	need	need	NOUN
admet-2043	470	23	for	for	ADP
admet-2043	470	24	careful	careful	ADJ
admet-2043	470	25	consideration	consideration	NOUN
admet-2043	470	26	.	.	PUNCT
admet-2043	471	1	liposomes	liposome	NOUN
admet-2043	471	2	,	,	PUNCT
admet-2043	471	3	spherical	spherical	ADJ
admet-2043	471	4	vesicles	vesicle	NOUN
admet-2043	471	5	with	with	ADP
admet-2043	471	6	lipid	lipid	ADJ
admet-2043	471	7	bilayers	bilayer	NOUN
admet-2043	471	8	,	,	PUNCT
admet-2043	471	9	offer	offer	VERB
admet-2043	471	10	efficient	efficient	ADJ
admet-2043	471	11	drug	drug	NOUN
admet-2043	471	12	delivery	delivery	NOUN
admet-2043	471	13	options	option	NOUN
admet-2043	471	14	with	with	ADP
admet-2043	471	15	inherent	inherent	ADJ
admet-2043	471	16	biocompatibility	biocompatibility	NOUN
admet-2043	471	17	.	.	PUNCT
admet-2043	472	1	surface	surface	NOUN
admet-2043	472	2	modifications	modification	NOUN
admet-2043	472	3	through	through	ADP
admet-2043	472	4	various	various	ADJ
admet-2043	472	5	compounds	compound	NOUN
admet-2043	472	6	allow	allow	VERB
admet-2043	472	7	targeted	target	VERB
admet-2043	472	8	delivery	delivery	NOUN
admet-2043	472	9	and	and	CCONJ
admet-2043	472	10	controlled	control	VERB
admet-2043	472	11	release	release	NOUN
admet-2043	472	12	of	of	ADP
admet-2043	472	13	therapeutic	therapeutic	ADJ
admet-2043	472	14	agents	agent	NOUN
admet-2043	472	15	.	.	PUNCT
admet-2043	473	1	solid	solid	ADJ
admet-2043	473	2	lipid	lipid	ADJ
admet-2043	473	3	nanoparticles	nanoparticle	NOUN
admet-2043	473	4	(	(	PUNCT
admet-2043	473	5	slns	slns	NOUN
admet-2043	473	6	)	)	PUNCT
admet-2043	473	7	,	,	PUNCT
admet-2043	473	8	resembling	resemble	VERB
admet-2043	473	9	liposomes	liposome	NOUN
admet-2043	473	10	but	but	CCONJ
admet-2043	473	11	with	with	ADP
admet-2043	473	12	a	a	DET
admet-2043	473	13	more	more	ADV
admet-2043	473	14	stable	stable	ADJ
admet-2043	473	15	structure	structure	NOUN
admet-2043	473	16	,	,	PUNCT
admet-2043	473	17	are	be	AUX
admet-2043	473	18	also	also	ADV
admet-2043	473	19	explored	explore	VERB
admet-2043	473	20	for	for	ADP
admet-2043	473	21	drug	drug	NOUN
admet-2043	473	22	delivery	delivery	NOUN
admet-2043	473	23	to	to	PART
admet-2043	473	24	treat	treat	VERB
admet-2043	473	25	brain	brain	NOUN
admet-2043	473	26	tumours	tumour	NOUN
admet-2043	473	27	.	.	PUNCT
admet-2043	474	1	cnts	cnts	PROPN
admet-2043	474	2	,	,	PUNCT
admet-2043	474	3	with	with	ADP
admet-2043	474	4	their	their	PRON
admet-2043	474	5	unique	unique	ADJ
admet-2043	474	6	characteristics	characteristic	NOUN
admet-2043	474	7	,	,	PUNCT
admet-2043	474	8	show	show	VERB
admet-2043	474	9	promise	promise	NOUN
admet-2043	474	10	in	in	ADP
admet-2043	474	11	cns	cns	NOUN
admet-2043	474	12	drug	drug	NOUN
admet-2043	474	13	delivery	delivery	NOUN
admet-2043	474	14	.	.	PUNCT
admet-2043	475	1	functionalized	functionalize	VERB
admet-2043	475	2	cnts	cnt	NOUN
admet-2043	475	3	can	can	AUX
admet-2043	475	4	effectively	effectively	ADV
admet-2043	475	5	cross	cross	VERB
admet-2043	475	6	the	the	DET
admet-2043	475	7	bbb	bbb	NOUN
admet-2043	475	8	and	and	CCONJ
admet-2043	475	9	may	may	AUX
admet-2043	475	10	serve	serve	VERB
admet-2043	475	11	as	as	ADP
admet-2043	475	12	carriers	carrier	NOUN
admet-2043	475	13	for	for	ADP
admet-2043	475	14	various	various	ADJ
admet-2043	475	15	therapeutic	therapeutic	ADJ
admet-2043	475	16	substances	substance	NOUN
admet-2043	475	17	.	.	PUNCT
admet-2043	476	1	however	however	ADV
admet-2043	476	2	,	,	PUNCT
admet-2043	476	3	challenges	challenge	NOUN
admet-2043	476	4	related	relate	VERB
admet-2043	476	5	to	to	ADP
admet-2043	476	6	toxicity	toxicity	NOUN
admet-2043	476	7	and	and	CCONJ
admet-2043	476	8	production	production	NOUN
admet-2043	476	9	costs	cost	NOUN
admet-2043	476	10	need	need	VERB
admet-2043	476	11	to	to	PART
admet-2043	476	12	be	be	AUX
admet-2043	476	13	addressed	address	VERB
admet-2043	476	14	.	.	PUNCT
admet-2043	477	1	surface	surface	NOUN
admet-2043	477	2	-	-	PUNCT
admet-2043	477	3	modified	modify	VERB
admet-2043	477	4	mwcnts	mwcnt	NOUN
admet-2043	477	5	have	have	VERB
admet-2043	477	6	the	the	DET
admet-2043	477	7	potential	potential	NOUN
admet-2043	477	8	to	to	PART
admet-2043	477	9	deliver	deliver	VERB
admet-2043	477	10	drugs	drug	NOUN
admet-2043	477	11	across	across	ADP
admet-2043	477	12	the	the	DET
admet-2043	477	13	bbs	bbs	PROPN
admet-2043	477	14	.	.	PUNCT
admet-2043	478	1	however	however	ADV
admet-2043	478	2	,	,	PUNCT
admet-2043	478	3	their	their	PRON
admet-2043	478	4	brain	brain	NOUN
admet-2043	478	5	permeability	permeability	NOUN
admet-2043	478	6	decreased	decrease	VERB
admet-2043	478	7	with	with	ADP
admet-2043	478	8	higher	high	ADJ
admet-2043	478	9	temperatures	temperature	NOUN
admet-2043	478	10	,	,	PUNCT
admet-2043	478	11	indicating	indicate	VERB
admet-2043	478	12	an	an	DET
admet-2043	478	13	energy	energy	NOUN
admet-2043	478	14	-	-	PUNCT
admet-2043	478	15	dependent	dependent	ADJ
admet-2043	478	16	mechanism	mechanism	NOUN
admet-2043	478	17	.	.	PUNCT
admet-2043	479	1	notably	notably	ADV
admet-2043	479	2	,	,	PUNCT
admet-2043	479	3	they	they	PRON
admet-2043	479	4	were	be	AUX
admet-2043	479	5	absorbed	absorb	VERB
admet-2043	479	6	significantly	significantly	ADV
admet-2043	479	7	by	by	ADP
admet-2043	479	8	astrocytes	astrocyte	NOUN
admet-2043	479	9	,	,	PUNCT
admet-2043	479	10	suggesting	suggest	VERB
admet-2043	479	11	their	their	PRON
admet-2043	479	12	potential	potential	NOUN
admet-2043	479	13	as	as	ADP
admet-2043	479	14	cns	cns	PROPN
admet-2043	479	15	drug	drug	NOUN
admet-2043	479	16	delivery	delivery	NOUN
admet-2043	479	17	vehicles	vehicle	NOUN
admet-2043	479	18	,	,	PUNCT
admet-2043	479	19	but	but	CCONJ
admet-2043	479	20	further	further	ADJ
admet-2043	479	21	research	research	NOUN
admet-2043	479	22	is	be	AUX
admet-2043	479	23	needed	need	VERB
admet-2043	479	24	to	to	PART
admet-2043	479	25	optimize	optimize	VERB
admet-2043	479	26	their	their	PRON
admet-2043	479	27	therapeutic	therapeutic	ADJ
admet-2043	479	28	application	application	NOUN
admet-2043	479	29	.	.	PUNCT
admet-2043	480	1	various	various	ADJ
admet-2043	480	2	models	model	NOUN
admet-2043	480	3	to	to	PART
admet-2043	480	4	study	study	VERB
admet-2043	480	5	bbb	bbb	PROPN
admet-2043	480	6	finding	find	VERB
admet-2043	480	7	innovative	innovative	ADJ
admet-2043	480	8	methods	method	NOUN
admet-2043	480	9	to	to	PART
admet-2043	480	10	administer	administer	VERB
admet-2043	480	11	medications	medication	NOUN
admet-2043	480	12	to	to	ADP
admet-2043	480	13	the	the	DET
admet-2043	480	14	brain	brain	NOUN
admet-2043	480	15	has	have	AUX
admet-2043	480	16	benefited	benefit	VERB
admet-2043	480	17	greatly	greatly	ADV
admet-2043	480	18	from	from	ADP
admet-2043	480	19	using	use	VERB
admet-2043	480	20	bbb	bbb	PROPN
admet-2043	480	21	in	in	ADP
admet-2043	480	22	vitro	vitro	X
admet-2043	480	23	models	model	NOUN
admet-2043	480	24	[	[	X
admet-2043	480	25	131	131	NUM
admet-2043	480	26	]	]	PUNCT
admet-2043	480	27	.	.	PUNCT
admet-2043	481	1	by	by	ADP
admet-2043	481	2	using	use	VERB
admet-2043	481	3	these	these	DET
admet-2043	481	4	models	model	NOUN
admet-2043	481	5	,	,	PUNCT
admet-2043	481	6	researchers	researcher	NOUN
admet-2043	481	7	have	have	AUX
admet-2043	481	8	been	be	AUX
admet-2043	481	9	able	able	ADJ
admet-2043	481	10	to	to	PART
admet-2043	481	11	test	test	VERB
admet-2043	481	12	the	the	DET
admet-2043	481	13	effectiveness	effectiveness	NOUN
admet-2043	481	14	of	of	ADP
admet-2043	481	15	nanomaterials	nanomaterial	NOUN
admet-2043	481	16	as	as	ADP
admet-2043	481	17	drug	drug	NOUN
admet-2043	481	18	delivery	delivery	NOUN
admet-2043	481	19	agents	agent	NOUN
admet-2043	481	20	to	to	PART
admet-2043	481	21	cross	cross	VERB
admet-2043	481	22	the	the	DET
admet-2043	481	23	blood	blood	NOUN
admet-2043	481	24	-	-	PUNCT
admet-2043	481	25	brain	brain	NOUN
admet-2043	481	26	barrier	barrier	NOUN
admet-2043	481	27	.	.	PUNCT
admet-2043	482	1	various	various	ADJ
admet-2043	482	2	nms	nms	NOUN
admet-2043	482	3	,	,	PUNCT
admet-2043	482	4	such	such	ADJ
admet-2043	482	5	as	as	ADP
admet-2043	482	6	liposomes	liposome	NOUN
admet-2043	482	7	,	,	PUNCT
admet-2043	482	8	dendrimers	dendrimer	NOUN
admet-2043	482	9	,	,	PUNCT
admet-2043	482	10	and	and	CCONJ
admet-2043	482	11	nanoparticles	nanoparticle	NOUN
admet-2043	482	12	,	,	PUNCT
admet-2043	482	13	have	have	AUX
admet-2043	482	14	demonstrated	demonstrate	VERB
admet-2043	482	15	efficacy	efficacy	NOUN
admet-2043	482	16	in	in	ADP
admet-2043	482	17	enhancing	enhance	VERB
admet-2043	482	18	drug	drug	NOUN
admet-2043	482	19	transport	transport	NOUN
admet-2043	482	20	across	across	ADP
admet-2043	482	21	the	the	DET
admet-2043	482	22	bbb	bbb	PROPN
admet-2043	482	23	.	.	PUNCT
admet-2043	483	1	these	these	DET
admet-2043	483	2	nms	nms	PROPN
admet-2043	483	3	can	can	AUX
admet-2043	483	4	be	be	AUX
admet-2043	483	5	customized	customize	VERB
admet-2043	483	6	to	to	PART
admet-2043	483	7	transport	transport	VERB
admet-2043	483	8	diverse	diverse	ADJ
admet-2043	483	9	types	type	NOUN
admet-2043	483	10	of	of	ADP
admet-2043	483	11	substances	substance	NOUN
admet-2043	483	12	and	and	CCONJ
admet-2043	483	13	can	can	AUX
admet-2043	483	14	enhance	enhance	VERB
admet-2043	483	15	the	the	DET
admet-2043	483	16	efficacy	efficacy	NOUN
admet-2043	483	17	of	of	ADP
admet-2043	483	18	drugs	drug	NOUN
admet-2043	483	19	by	by	ADP
admet-2043	483	20	increasing	increase	VERB
admet-2043	483	21	their	their	PRON
admet-2043	483	22	specificity	specificity	NOUN
admet-2043	483	23	,	,	PUNCT
admet-2043	483	24	reducing	reduce	VERB
admet-2043	483	25	toxicity	toxicity	NOUN
admet-2043	483	26	,	,	PUNCT
admet-2043	483	27	and	and	CCONJ
admet-2043	483	28	facilitating	facilitate	VERB
admet-2043	483	29	their	their	PRON
admet-2043	483	30	delivery	delivery	NOUN
admet-2043	483	31	to	to	ADP
admet-2043	483	32	specific	specific	ADJ
admet-2043	483	33	areas	area	NOUN
admet-2043	483	34	of	of	ADP
admet-2043	483	35	the	the	DET
admet-2043	483	36	brain	brain	NOUN
admet-2043	484	1	[	[	X
admet-2043	484	2	132,133	132,133	NUM
admet-2043	484	3	]	]	PUNCT
admet-2043	484	4	.	.	PUNCT
admet-2043	485	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	485	2	m.	m.	NOUN
admet-2043	485	3	kulkarni	kulkarni	PROPN
admet-2043	485	4	et	et	PROPN
admet-2043	485	5	al	al	PROPN
admet-2043	485	6	.	.	PROPN
admet-2043	485	7	admet	admet	PROPN
admet-2043	485	8	&	&	CCONJ
admet-2043	485	9	dmpk	dmpk	PROPN
admet-2043	485	10	12(1	12(1	PROPN
admet-2043	485	11	)	)	PUNCT
admet-2043	485	12	(	(	PUNCT
admet-2043	485	13	2024	2024	NUM
admet-2043	485	14	)	)	PUNCT
admet-2043	485	15	63	63	NUM
admet-2043	485	16	-	-	SYM
admet-2043	485	17	105	105	NUM
admet-2043	485	18	82	82	NUM
admet-2043	485	19	the	the	DET
admet-2043	485	20	capacity	capacity	NOUN
admet-2043	485	21	of	of	ADP
admet-2043	485	22	functionalized	functionalized	ADJ
admet-2043	485	23	nms	nms	NOUN
admet-2043	485	24	to	to	PART
admet-2043	485	25	preferentially	preferentially	ADV
admet-2043	485	26	attach	attach	VERB
admet-2043	485	27	to	to	ADP
admet-2043	485	28	receptors	receptor	NOUN
admet-2043	485	29	on	on	ADP
admet-2043	485	30	the	the	DET
admet-2043	485	31	surface	surface	NOUN
admet-2043	485	32	of	of	ADP
admet-2043	485	33	bbb	bbb	PROPN
admet-2043	485	34	endothelial	endothelial	ADJ
admet-2043	485	35	cells	cell	NOUN
admet-2043	485	36	,	,	PUNCT
admet-2043	485	37	which	which	PRON
admet-2043	485	38	increases	increase	VERB
admet-2043	485	39	their	their	PRON
admet-2043	485	40	ability	ability	NOUN
admet-2043	485	41	to	to	PART
admet-2043	485	42	pass	pass	VERB
admet-2043	485	43	the	the	DET
admet-2043	485	44	barrier	barrier	NOUN
admet-2043	485	45	,	,	PUNCT
admet-2043	485	46	is	be	AUX
admet-2043	485	47	a	a	DET
admet-2043	485	48	significant	significant	ADJ
admet-2043	485	49	benefit	benefit	NOUN
admet-2043	485	50	.	.	PUNCT
admet-2043	486	1	understanding	understand	VERB
admet-2043	486	2	these	these	DET
admet-2043	486	3	transport	transport	NOUN
admet-2043	486	4	systems	system	NOUN
admet-2043	486	5	and	and	CCONJ
admet-2043	486	6	determining	determine	VERB
admet-2043	486	7	the	the	DET
admet-2043	486	8	safety	safety	NOUN
admet-2043	486	9	of	of	ADP
admet-2043	486	10	nanomaterials	nanomaterial	NOUN
admet-2043	486	11	for	for	ADP
admet-2043	486	12	delivering	deliver	VERB
admet-2043	486	13	medications	medication	NOUN
admet-2043	486	14	to	to	ADP
admet-2043	486	15	the	the	DET
admet-2043	486	16	brain	brain	NOUN
admet-2043	486	17	have	have	AUX
admet-2043	486	18	benefited	benefit	VERB
admet-2043	486	19	greatly	greatly	ADV
admet-2043	486	20	from	from	ADP
admet-2043	486	21	in	in	ADP
admet-2043	486	22	vitro	vitro	X
admet-2043	486	23	research	research	NOUN
admet-2043	486	24	[	[	X
admet-2043	486	25	134	134	NUM
admet-2043	486	26	]	]	PUNCT
admet-2043	486	27	.	.	PUNCT
admet-2043	487	1	overall	overall	ADJ
admet-2043	487	2	,	,	PUNCT
admet-2043	487	3	in	in	ADP
admet-2043	487	4	vitro	vitro	X
admet-2043	487	5	models	model	NOUN
admet-2043	487	6	of	of	ADP
admet-2043	487	7	the	the	DET
admet-2043	487	8	bbb	bbb	PROPN
admet-2043	487	9	have	have	AUX
admet-2043	487	10	played	play	VERB
admet-2043	487	11	an	an	DET
admet-2043	487	12	important	important	ADJ
admet-2043	487	13	role	role	NOUN
admet-2043	487	14	in	in	ADP
admet-2043	487	15	advancing	advance	VERB
admet-2043	487	16	drug	drug	NOUN
admet-2043	487	17	delivery	delivery	NOUN
admet-2043	487	18	strategies	strategy	NOUN
admet-2043	487	19	for	for	ADP
admet-2043	487	20	overcoming	overcome	VERB
admet-2043	487	21	the	the	DET
admet-2043	487	22	bbb	bbb	NOUN
admet-2043	487	23	[	[	X
admet-2043	487	24	135	135	NUM
admet-2043	487	25	]	]	PUNCT
admet-2043	487	26	.	.	PUNCT
admet-2043	488	1	nms	nms	NOUN
admet-2043	488	2	have	have	AUX
admet-2043	488	3	proven	prove	VERB
admet-2043	488	4	to	to	PART
admet-2043	488	5	be	be	AUX
admet-2043	488	6	effective	effective	ADJ
admet-2043	488	7	in	in	ADP
admet-2043	488	8	enhancing	enhance	VERB
admet-2043	488	9	drug	drug	NOUN
admet-2043	488	10	delivery	delivery	NOUN
admet-2043	488	11	to	to	ADP
admet-2043	488	12	the	the	DET
admet-2043	488	13	brain	brain	NOUN
admet-2043	488	14	,	,	PUNCT
admet-2043	488	15	and	and	CCONJ
admet-2043	488	16	in	in	ADP
admet-2043	488	17	vitro	vitro	X
admet-2043	488	18	research	research	NOUN
admet-2043	488	19	has	have	AUX
admet-2043	488	20	provided	provide	VERB
admet-2043	488	21	valuable	valuable	ADJ
admet-2043	488	22	information	information	NOUN
admet-2043	488	23	about	about	ADP
admet-2043	488	24	their	their	PRON
admet-2043	488	25	mechanisms	mechanism	NOUN
admet-2043	488	26	of	of	ADP
admet-2043	488	27	transport	transport	NOUN
admet-2043	488	28	and	and	CCONJ
admet-2043	488	29	safety	safety	NOUN
admet-2043	488	30	.	.	PUNCT
admet-2043	489	1	additionally	additionally	ADV
admet-2043	489	2	,	,	PUNCT
admet-2043	489	3	in	in	ADP
admet-2043	489	4	vitro	vitro	X
admet-2043	489	5	models	model	NOUN
admet-2043	489	6	of	of	ADP
admet-2043	489	7	the	the	DET
admet-2043	489	8	bbb	bbb	NOUN
admet-2043	489	9	can	can	AUX
admet-2043	489	10	be	be	AUX
admet-2043	489	11	used	use	VERB
admet-2043	489	12	for	for	ADP
admet-2043	489	13	drug	drug	NOUN
admet-2043	489	14	screening	screening	NOUN
admet-2043	489	15	,	,	PUNCT
admet-2043	489	16	including	include	VERB
admet-2043	489	17	the	the	DET
admet-2043	489	18	use	use	NOUN
admet-2043	489	19	of	of	ADP
admet-2043	489	20	microfluidic	microfluidic	ADJ
admet-2043	489	21	devices	device	NOUN
admet-2043	489	22	for	for	ADP
admet-2043	489	23	high	high	ADJ
admet-2043	489	24	-	-	PUNCT
admet-2043	489	25	throughput	throughput	NOUN
admet-2043	489	26	screening	screening	NOUN
admet-2043	489	27	[	[	X
admet-2043	489	28	136	136	NUM
admet-2043	489	29	]	]	PUNCT
admet-2043	489	30	.	.	PUNCT
admet-2043	490	1	two	two	NUM
admet-2043	490	2	popular	popular	ADJ
admet-2043	490	3	in	in	ADP
admet-2043	490	4	vitro	vitro	X
admet-2043	490	5	models	model	NOUN
admet-2043	490	6	for	for	ADP
admet-2043	490	7	investigating	investigate	VERB
admet-2043	490	8	the	the	DET
admet-2043	490	9	bbb	bbb	NOUN
admet-2043	490	10	and	and	CCONJ
admet-2043	490	11	assessing	assess	VERB
admet-2043	490	12	the	the	DET
admet-2043	490	13	feasibility	feasibility	NOUN
admet-2043	490	14	of	of	ADP
admet-2043	490	15	nms	nms	NOUN
admet-2043	490	16	in	in	ADP
admet-2043	490	17	crossing	cross	VERB
admet-2043	490	18	this	this	DET
admet-2043	490	19	barrier	barrier	NOUN
admet-2043	490	20	for	for	ADP
admet-2043	490	21	drug	drug	NOUN
admet-2043	490	22	delivery	delivery	NOUN
admet-2043	490	23	to	to	ADP
admet-2043	490	24	the	the	DET
admet-2043	490	25	brain	brain	NOUN
admet-2043	490	26	are	be	AUX
admet-2043	490	27	cell	cell	NOUN
admet-2043	490	28	-	-	PUNCT
admet-2043	490	29	based	base	VERB
admet-2043	490	30	models	model	NOUN
admet-2043	490	31	and	and	CCONJ
admet-2043	490	32	microfluidic	microfluidic	ADJ
admet-2043	490	33	devices	device	NOUN
admet-2043	490	34	.	.	PUNCT
admet-2043	491	1	cell	cell	NOUN
admet-2043	491	2	-	-	PUNCT
admet-2043	491	3	based	base	VERB
admet-2043	491	4	models	model	NOUN
admet-2043	491	5	are	be	AUX
admet-2043	491	6	frequently	frequently	ADV
admet-2043	491	7	utilized	utilize	VERB
admet-2043	491	8	in	in	ADP
admet-2043	491	9	vitro	vitro	X
admet-2043	491	10	models	model	NOUN
admet-2043	491	11	to	to	PART
admet-2043	491	12	study	study	VERB
admet-2043	491	13	the	the	DET
admet-2043	491	14	bbb	bbb	PROPN
admet-2043	491	15	.	.	PUNCT
admet-2043	492	1	these	these	DET
admet-2043	492	2	models	model	NOUN
admet-2043	492	3	involve	involve	VERB
admet-2043	492	4	using	use	VERB
admet-2043	492	5	various	various	ADJ
admet-2043	492	6	cells	cell	NOUN
admet-2043	492	7	to	to	PART
admet-2043	492	8	imitate	imitate	VERB
admet-2043	492	9	the	the	DET
admet-2043	492	10	bbb	bbb	NOUN
admet-2043	492	11	structure	structure	NOUN
admet-2043	492	12	.	.	PUNCT
admet-2043	493	1	for	for	ADP
admet-2043	493	2	instance	instance	NOUN
admet-2043	493	3	,	,	PUNCT
admet-2043	493	4	a	a	DET
admet-2043	493	5	widely	widely	ADV
admet-2043	493	6	used	use	VERB
admet-2043	493	7	cell	cell	NOUN
admet-2043	493	8	-	-	PUNCT
admet-2043	493	9	based	base	VERB
admet-2043	493	10	model	model	NOUN
admet-2043	493	11	entails	entail	VERB
admet-2043	493	12	cultivating	cultivate	VERB
admet-2043	493	13	bmecs	bmec	NOUN
admet-2043	493	14	on	on	ADP
admet-2043	493	15	a	a	DET
admet-2043	493	16	transwell	transwell	NOUN
admet-2043	493	17	membrane	membrane	NOUN
admet-2043	493	18	to	to	PART
admet-2043	493	19	form	form	VERB
admet-2043	493	20	a	a	DET
admet-2043	493	21	monolayer	monolayer	NOUN
admet-2043	493	22	with	with	ADP
admet-2043	493	23	tight	tight	ADJ
admet-2043	493	24	junctions	junction	NOUN
admet-2043	493	25	,	,	PUNCT
admet-2043	493	26	mimicking	mimic	VERB
admet-2043	493	27	the	the	DET
admet-2043	493	28	bbb	bbb	NOUN
admet-2043	493	29	structure	structure	NOUN
admet-2043	493	30	[	[	X
admet-2043	493	31	137,138	137,138	NUM
admet-2043	493	32	]	]	PUNCT
admet-2043	493	33	.	.	PUNCT
admet-2043	494	1	a	a	PRON
admet-2043	494	2	more	more	ADV
admet-2043	494	3	intricate	intricate	ADJ
admet-2043	494	4	in	in	ADP
admet-2043	494	5	vitro	vitro	X
admet-2043	494	6	bbb	bbb	PROPN
admet-2043	494	7	model	model	NOUN
admet-2043	494	8	can	can	AUX
admet-2043	494	9	be	be	AUX
admet-2043	494	10	formed	form	VERB
admet-2043	494	11	by	by	ADP
admet-2043	494	12	including	include	VERB
admet-2043	494	13	other	other	ADJ
admet-2043	494	14	cell	cell	NOUN
admet-2043	494	15	types	type	NOUN
admet-2043	494	16	like	like	ADP
admet-2043	494	17	astrocytes	astrocyte	NOUN
admet-2043	494	18	and	and	CCONJ
admet-2043	494	19	pericytes	pericyte	NOUN
admet-2043	494	20	,	,	PUNCT
admet-2043	494	21	along	along	ADP
admet-2043	494	22	with	with	ADP
admet-2043	494	23	brain	brain	NOUN
admet-2043	494	24	microvascular	microvascular	NOUN
admet-2043	494	25	endothelial	endothelial	ADJ
admet-2043	494	26	cells	cell	NOUN
admet-2043	494	27	(	(	PUNCT
admet-2043	494	28	bmecs	bmecs	NOUN
admet-2043	494	29	)	)	PUNCT
admet-2043	494	30	,	,	PUNCT
admet-2043	494	31	to	to	PART
admet-2043	494	32	mimic	mimic	VERB
admet-2043	494	33	the	the	DET
admet-2043	494	34	bbb	bbb	NOUN
admet-2043	494	35	structure	structure	NOUN
admet-2043	494	36	[	[	X
admet-2043	494	37	2	2	NUM
admet-2043	494	38	]	]	PUNCT
admet-2043	494	39	.	.	PUNCT
admet-2043	495	1	cellbased	cellbase	VERB
admet-2043	495	2	models	model	NOUN
admet-2043	495	3	offer	offer	VERB
admet-2043	495	4	a	a	DET
admet-2043	495	5	controlled	control	VERB
admet-2043	495	6	and	and	CCONJ
admet-2043	495	7	reproducible	reproducible	VERB
admet-2043	495	8	experimental	experimental	ADJ
admet-2043	495	9	system	system	NOUN
admet-2043	495	10	for	for	ADP
admet-2043	495	11	drug	drug	NOUN
admet-2043	495	12	screening	screening	NOUN
admet-2043	495	13	and	and	CCONJ
admet-2043	495	14	studying	study	VERB
admet-2043	495	15	bbb	bbb	PROPN
admet-2043	495	16	transport	transport	NOUN
admet-2043	495	17	mechanisms	mechanism	NOUN
admet-2043	495	18	,	,	PUNCT
admet-2043	495	19	which	which	PRON
admet-2043	495	20	is	be	AUX
admet-2043	495	21	a	a	DET
admet-2043	495	22	significant	significant	ADJ
admet-2043	495	23	advantage	advantage	NOUN
admet-2043	495	24	[	[	X
admet-2043	495	25	139	139	NUM
admet-2043	495	26	]	]	PUNCT
admet-2043	495	27	.	.	PUNCT
admet-2043	496	1	although	although	SCONJ
admet-2043	496	2	cell	cell	NOUN
admet-2043	496	3	-	-	PUNCT
admet-2043	496	4	based	base	VERB
admet-2043	496	5	models	model	NOUN
admet-2043	496	6	are	be	AUX
admet-2043	496	7	valuable	valuable	ADJ
admet-2043	496	8	tools	tool	NOUN
admet-2043	496	9	for	for	ADP
admet-2043	496	10	studying	study	VERB
admet-2043	496	11	the	the	DET
admet-2043	496	12	bbb	bbb	NOUN
admet-2043	496	13	,	,	PUNCT
admet-2043	496	14	they	they	PRON
admet-2043	496	15	have	have	VERB
admet-2043	496	16	some	some	DET
admet-2043	496	17	limitations	limitation	NOUN
admet-2043	496	18	.	.	PUNCT
admet-2043	497	1	for	for	ADP
admet-2043	497	2	instance	instance	NOUN
admet-2043	497	3	,	,	PUNCT
admet-2043	497	4	they	they	PRON
admet-2043	497	5	lack	lack	VERB
admet-2043	497	6	fluid	fluid	ADJ
admet-2043	497	7	shear	shear	NOUN
admet-2043	497	8	stress	stress	NOUN
admet-2043	497	9	and	and	CCONJ
admet-2043	497	10	other	other	ADJ
admet-2043	497	11	components	component	NOUN
admet-2043	497	12	of	of	ADP
admet-2043	497	13	the	the	DET
admet-2043	497	14	bbb	bbb	PROPN
admet-2043	497	15	,	,	PUNCT
admet-2043	497	16	which	which	PRON
admet-2043	497	17	can	can	AUX
admet-2043	497	18	result	result	VERB
admet-2043	497	19	in	in	ADP
admet-2043	497	20	inaccurate	inaccurate	ADJ
admet-2043	497	21	estimations	estimation	NOUN
admet-2043	497	22	of	of	ADP
admet-2043	497	23	drug	drug	NOUN
admet-2043	497	24	transport	transport	NOUN
admet-2043	497	25	[	[	X
admet-2043	497	26	140	140	NUM
admet-2043	497	27	]	]	PUNCT
admet-2043	497	28	.	.	PUNCT
admet-2043	498	1	in	in	ADP
admet-2043	498	2	vitro	vitro	X
admet-2043	498	3	bbb	bbb	PROPN
admet-2043	498	4	models	model	NOUN
admet-2043	498	5	offer	offer	VERB
admet-2043	498	6	a	a	DET
admet-2043	498	7	reliable	reliable	ADJ
admet-2043	498	8	and	and	CCONJ
admet-2043	498	9	standardized	standardized	ADJ
admet-2043	498	10	experimental	experimental	ADJ
admet-2043	498	11	platform	platform	NOUN
admet-2043	498	12	for	for	ADP
admet-2043	498	13	drug	drug	NOUN
admet-2043	498	14	screening	screening	NOUN
admet-2043	498	15	and	and	CCONJ
admet-2043	498	16	for	for	ADP
admet-2043	498	17	studying	study	VERB
admet-2043	498	18	the	the	DET
admet-2043	498	19	mechanisms	mechanism	NOUN
admet-2043	498	20	of	of	ADP
admet-2043	498	21	bbb	bbb	PROPN
admet-2043	498	22	transport	transport	NOUN
admet-2043	498	23	[	[	X
admet-2043	498	24	138	138	NUM
admet-2043	498	25	]	]	PUNCT
admet-2043	498	26	,	,	PUNCT
admet-2043	498	27	but	but	CCONJ
admet-2043	498	28	it	it	PRON
admet-2043	498	29	is	be	AUX
admet-2043	498	30	important	important	ADJ
admet-2043	498	31	to	to	PART
admet-2043	498	32	acknowledge	acknowledge	VERB
admet-2043	498	33	that	that	SCONJ
admet-2043	498	34	these	these	DET
admet-2043	498	35	models	model	NOUN
admet-2043	498	36	have	have	VERB
admet-2043	498	37	limitations	limitation	NOUN
admet-2043	498	38	,	,	PUNCT
admet-2043	498	39	including	include	VERB
admet-2043	498	40	the	the	DET
admet-2043	498	41	absence	absence	NOUN
admet-2043	498	42	of	of	ADP
admet-2043	498	43	important	important	ADJ
admet-2043	498	44	bbb	bbb	ADJ
admet-2043	498	45	components	component	NOUN
admet-2043	498	46	and	and	CCONJ
admet-2043	498	47	fluid	fluid	ADJ
admet-2043	498	48	shear	shear	NOUN
admet-2043	498	49	stress	stress	NOUN
admet-2043	498	50	,	,	PUNCT
admet-2043	498	51	which	which	PRON
admet-2043	498	52	can	can	AUX
admet-2043	498	53	lead	lead	VERB
admet-2043	498	54	to	to	ADP
admet-2043	498	55	overestimation	overestimation	NOUN
admet-2043	498	56	or	or	CCONJ
admet-2043	498	57	underestimation	underestimation	NOUN
admet-2043	498	58	of	of	ADP
admet-2043	498	59	drug	drug	NOUN
admet-2043	498	60	transport	transport	NOUN
admet-2043	499	1	[	[	X
admet-2043	499	2	140	140	NUM
admet-2043	499	3	]	]	PUNCT
admet-2043	499	4	.	.	PUNCT
admet-2043	500	1	cell	cell	NOUN
admet-2043	500	2	-	-	PUNCT
admet-2043	500	3	based	base	VERB
admet-2043	500	4	models	model	NOUN
admet-2043	500	5	used	use	VERB
admet-2043	500	6	to	to	PART
admet-2043	500	7	study	study	VERB
admet-2043	500	8	the	the	DET
admet-2043	500	9	bbb	bbb	NOUN
admet-2043	500	10	in	in	ADP
admet-2043	500	11	vitro	vitro	NOUN
admet-2043	500	12	,	,	PUNCT
admet-2043	500	13	referred	refer	VERB
admet-2043	500	14	to	to	ADP
admet-2043	500	15	as	as	ADP
admet-2043	500	16	static	static	ADJ
admet-2043	500	17	models	model	NOUN
admet-2043	500	18	,	,	PUNCT
admet-2043	500	19	offer	offer	VERB
admet-2043	500	20	several	several	ADJ
admet-2043	500	21	benefits	benefit	NOUN
admet-2043	500	22	,	,	PUNCT
admet-2043	500	23	including	include	VERB
admet-2043	500	24	reproducibility	reproducibility	NOUN
admet-2043	500	25	,	,	PUNCT
admet-2043	500	26	scalability	scalability	NOUN
admet-2043	500	27	,	,	PUNCT
admet-2043	500	28	and	and	CCONJ
admet-2043	500	29	costeffectiveness	costeffectiveness	NOUN
admet-2043	500	30	.	.	PUNCT
admet-2043	501	1	however	however	ADV
admet-2043	501	2	,	,	PUNCT
admet-2043	501	3	these	these	DET
admet-2043	501	4	models	model	NOUN
admet-2043	501	5	are	be	AUX
admet-2043	501	6	limited	limit	VERB
admet-2043	501	7	in	in	ADP
admet-2043	501	8	their	their	PRON
admet-2043	501	9	ability	ability	NOUN
admet-2043	501	10	to	to	PART
admet-2043	501	11	mimic	mimic	VERB
admet-2043	501	12	the	the	DET
admet-2043	501	13	physiological	physiological	ADJ
admet-2043	501	14	environment	environment	NOUN
admet-2043	501	15	of	of	ADP
admet-2043	501	16	the	the	DET
admet-2043	501	17	bbb	bbb	PROPN
admet-2043	501	18	,	,	PUNCT
admet-2043	501	19	lacking	lack	VERB
admet-2043	501	20	fluid	fluid	ADJ
admet-2043	501	21	shear	shear	NOUN
admet-2043	501	22	stress	stress	NOUN
admet-2043	501	23	and	and	CCONJ
admet-2043	501	24	other	other	ADJ
admet-2043	501	25	important	important	ADJ
admet-2043	501	26	components	component	NOUN
admet-2043	502	1	[	[	X
admet-2043	502	2	139	139	NUM
admet-2043	502	3	]	]	PUNCT
admet-2043	502	4	.	.	PUNCT
admet-2043	503	1	nonetheless	nonetheless	ADV
admet-2043	503	2	,	,	PUNCT
admet-2043	503	3	they	they	PRON
admet-2043	503	4	fall	fall	VERB
admet-2043	503	5	short	short	ADV
admet-2043	503	6	in	in	ADP
admet-2043	503	7	simulating	simulate	VERB
admet-2043	503	8	the	the	DET
admet-2043	503	9	dynamic	dynamic	ADJ
admet-2043	503	10	fluid	fluid	NOUN
admet-2043	503	11	flow	flow	NOUN
admet-2043	503	12	and	and	CCONJ
admet-2043	503	13	mechanical	mechanical	ADJ
admet-2043	503	14	forces	force	NOUN
admet-2043	503	15	present	present	ADJ
admet-2043	503	16	in	in	ADP
admet-2043	503	17	vivo	vivo	NOUN
admet-2043	503	18	,	,	PUNCT
admet-2043	503	19	which	which	PRON
admet-2043	503	20	can	can	AUX
admet-2043	503	21	significantly	significantly	ADV
admet-2043	503	22	influence	influence	VERB
admet-2043	503	23	drug	drug	NOUN
admet-2043	503	24	transport	transport	NOUN
admet-2043	503	25	and	and	CCONJ
admet-2043	503	26	cell	cell	NOUN
admet-2043	503	27	behaviour	behaviour	NOUN
admet-2043	504	1	[	[	X
admet-2043	504	2	140	140	NUM
admet-2043	504	3	]	]	PUNCT
admet-2043	504	4	.	.	PUNCT
admet-2043	505	1	other	other	ADJ
admet-2043	505	2	static	static	ADJ
admet-2043	505	3	models	model	NOUN
admet-2043	505	4	involving	involve	VERB
admet-2043	505	5	different	different	ADJ
admet-2043	505	6	types	type	NOUN
admet-2043	505	7	of	of	ADP
admet-2043	505	8	cells	cell	NOUN
admet-2043	505	9	,	,	PUNCT
admet-2043	505	10	including	include	VERB
admet-2043	505	11	astrocytes	astrocyte	NOUN
admet-2043	505	12	and	and	CCONJ
admet-2043	505	13	pericytes	pericyte	NOUN
admet-2043	505	14	,	,	PUNCT
admet-2043	505	15	can	can	AUX
admet-2043	505	16	be	be	AUX
admet-2043	505	17	used	use	VERB
admet-2043	505	18	in	in	ADP
admet-2043	505	19	addition	addition	NOUN
admet-2043	505	20	to	to	ADP
admet-2043	505	21	the	the	DET
admet-2043	505	22	commonly	commonly	ADV
admet-2043	505	23	used	use	VERB
admet-2043	505	24	transwell	transwell	NOUN
admet-2043	505	25	model	model	NOUN
admet-2043	505	26	with	with	ADP
admet-2043	505	27	bmecs	bmecs	PROPN
admet-2043	505	28	to	to	PART
admet-2043	505	29	create	create	VERB
admet-2043	505	30	more	more	ADV
admet-2043	505	31	complex	complex	ADJ
admet-2043	505	32	in	in	ADP
admet-2043	505	33	vitro	vitro	X
admet-2043	505	34	bbb	bbb	PROPN
admet-2043	505	35	models	model	NOUN
admet-2043	505	36	for	for	ADP
admet-2043	505	37	studying	study	VERB
admet-2043	505	38	drug	drug	NOUN
admet-2043	505	39	transport	transport	NOUN
admet-2043	505	40	and	and	CCONJ
admet-2043	505	41	evaluating	evaluate	VERB
admet-2043	505	42	the	the	DET
admet-2043	505	43	potential	potential	NOUN
admet-2043	505	44	of	of	ADP
admet-2043	505	45	nanomaterials	nanomaterial	NOUN
admet-2043	505	46	for	for	ADP
admet-2043	505	47	overcoming	overcome	VERB
admet-2043	505	48	the	the	DET
admet-2043	505	49	bbb	bbb	PROPN
admet-2043	505	50	.	.	PUNCT
admet-2043	506	1	static	static	PROPN
admet-2043	506	2	in	in	ADP
admet-2043	506	3	vitro	vitro	X
admet-2043	506	4	bbb	bbb	PROPN
admet-2043	506	5	models	model	NOUN
admet-2043	506	6	relate	relate	VERB
admet-2043	506	7	to	to	ADP
admet-2043	506	8	using	use	VERB
admet-2043	506	9	cultured	cultured	ADJ
admet-2043	506	10	cells	cell	NOUN
admet-2043	506	11	in	in	ADP
admet-2043	506	12	a	a	DET
admet-2043	506	13	static	static	ADJ
admet-2043	506	14	environment	environment	NOUN
admet-2043	506	15	to	to	PART
admet-2043	506	16	simulate	simulate	VERB
admet-2043	506	17	the	the	DET
admet-2043	506	18	bbb	bbb	NOUN
admet-2043	506	19	,	,	PUNCT
admet-2043	506	20	known	know	VERB
admet-2043	506	21	as	as	ADP
admet-2043	506	22	static	static	ADJ
admet-2043	506	23	in	in	ADP
admet-2043	506	24	vitro	vitro	X
admet-2043	506	25	bbb	bbb	PROPN
admet-2043	506	26	models	model	NOUN
admet-2043	506	27	.	.	PUNCT
admet-2043	507	1	these	these	DET
admet-2043	507	2	models	model	NOUN
admet-2043	507	3	are	be	AUX
admet-2043	507	4	beneficial	beneficial	ADJ
admet-2043	507	5	in	in	ADP
admet-2043	507	6	investigating	investigate	VERB
admet-2043	507	7	drug	drug	NOUN
admet-2043	507	8	efficacy	efficacy	NOUN
admet-2043	507	9	,	,	PUNCT
admet-2043	507	10	drug	drug	NOUN
admet-2043	507	11	transport	transport	NOUN
admet-2043	507	12	,	,	PUNCT
admet-2043	507	13	and	and	CCONJ
admet-2043	507	14	bbb	bbb	NOUN
admet-2043	507	15	permeability	permeability	NOUN
admet-2043	507	16	in	in	ADP
admet-2043	507	17	vitro	vitro	VERB
admet-2043	507	18	.	.	PUNCT
admet-2043	508	1	the	the	DET
admet-2043	508	2	bbb	bbb	PROPN
admet-2043	508	3	consists	consist	VERB
admet-2043	508	4	of	of	ADP
admet-2043	508	5	three	three	NUM
admet-2043	508	6	key	key	ADJ
admet-2043	508	7	cell	cell	NOUN
admet-2043	508	8	types	type	NOUN
admet-2043	508	9	:	:	PUNCT
admet-2043	508	10	brain	brain	NOUN
admet-2043	508	11	endothelial	endothelial	ADJ
admet-2043	508	12	cells	cell	NOUN
admet-2043	508	13	,	,	PUNCT
admet-2043	508	14	astrocytes	astrocyte	NOUN
admet-2043	508	15	,	,	PUNCT
admet-2043	508	16	and	and	CCONJ
admet-2043	508	17	pericytes	pericyte	NOUN
admet-2043	508	18	[	[	X
admet-2043	508	19	141	141	NUM
admet-2043	508	20	]	]	PUNCT
admet-2043	508	21	.	.	PUNCT
admet-2043	509	1	static	static	PROPN
admet-2043	509	2	in	in	ADP
admet-2043	509	3	vitro	vitro	X
admet-2043	509	4	models	model	NOUN
admet-2043	509	5	usually	usually	ADV
admet-2043	509	6	involve	involve	VERB
admet-2043	509	7	culturing	culture	VERB
admet-2043	509	8	brain	brain	NOUN
admet-2043	509	9	endothelial	endothelial	ADJ
admet-2043	509	10	cells	cell	NOUN
admet-2043	509	11	on	on	ADP
admet-2043	509	12	a	a	DET
admet-2043	509	13	permeable	permeable	ADJ
admet-2043	509	14	membrane	membrane	NOUN
admet-2043	509	15	with	with	ADP
admet-2043	509	16	astrocytes	astrocyte	NOUN
admet-2043	509	17	and	and	CCONJ
admet-2043	509	18	pericytes	pericyte	NOUN
admet-2043	509	19	in	in	ADP
admet-2043	509	20	the	the	DET
admet-2043	509	21	culture	culture	NOUN
admet-2043	509	22	medium	medium	NOUN
admet-2043	509	23	.	.	PUNCT
admet-2043	510	1	however	however	ADV
admet-2043	510	2	,	,	PUNCT
admet-2043	510	3	simpler	simple	ADJ
admet-2043	510	4	models	model	NOUN
admet-2043	510	5	that	that	PRON
admet-2043	510	6	only	only	ADV
admet-2043	510	7	consist	consist	VERB
admet-2043	510	8	of	of	ADP
admet-2043	510	9	endothelial	endothelial	ADJ
admet-2043	510	10	cells	cell	NOUN
admet-2043	510	11	can	can	AUX
admet-2043	510	12	also	also	ADV
admet-2043	510	13	be	be	AUX
admet-2043	510	14	employed	employ	VERB
admet-2043	510	15	.	.	PUNCT
admet-2043	511	1	[	[	X
admet-2043	511	2	142	142	NUM
admet-2043	511	3	]	]	PUNCT
admet-2043	511	4	.	.	PUNCT
admet-2043	512	1	static	static	PROPN
admet-2043	512	2	in	in	ADP
admet-2043	512	3	vitro	vitro	X
admet-2043	512	4	models	model	NOUN
admet-2043	512	5	are	be	AUX
admet-2043	512	6	advantageous	advantageous	ADJ
admet-2043	512	7	due	due	ADP
admet-2043	512	8	to	to	ADP
admet-2043	512	9	their	their	PRON
admet-2043	512	10	ability	ability	NOUN
admet-2043	512	11	to	to	PART
admet-2043	512	12	provide	provide	VERB
admet-2043	512	13	a	a	DET
admet-2043	512	14	reproducible	reproducible	ADJ
admet-2043	512	15	,	,	PUNCT
admet-2043	512	16	scalable	scalable	ADJ
admet-2043	512	17	,	,	PUNCT
admet-2043	512	18	and	and	CCONJ
admet-2043	512	19	costeffective	costeffective	ADJ
admet-2043	512	20	experimental	experimental	ADJ
admet-2043	512	21	system	system	NOUN
admet-2043	512	22	for	for	ADP
admet-2043	512	23	studying	study	VERB
admet-2043	512	24	bbb	bbb	PROPN
admet-2043	512	25	permeability	permeability	NOUN
admet-2043	512	26	,	,	PUNCT
admet-2043	512	27	drug	drug	NOUN
admet-2043	512	28	transport	transport	NOUN
admet-2043	512	29	,	,	PUNCT
admet-2043	512	30	and	and	CCONJ
admet-2043	512	31	drug	drug	NOUN
admet-2043	512	32	efficacy	efficacy	NOUN
admet-2043	512	33	in	in	ADP
admet-2043	512	34	vitro	vitro	X
admet-2043	512	35	[	[	X
admet-2043	512	36	143	143	NUM
admet-2043	512	37	]	]	PUNCT
admet-2043	512	38	.	.	PUNCT
admet-2043	513	1	static	static	PROPN
admet-2043	513	2	in	in	ADP
admet-2043	513	3	vitro	vitro	X
admet-2043	513	4	models	model	NOUN
admet-2043	513	5	offer	offer	VERB
admet-2043	513	6	the	the	DET
admet-2043	513	7	advantage	advantage	NOUN
admet-2043	513	8	of	of	ADP
admet-2043	513	9	being	be	AUX
admet-2043	513	10	less	less	ADV
admet-2043	513	11	complex	complex	ADJ
admet-2043	513	12	than	than	ADP
admet-2043	513	13	in	in	ADP
admet-2043	513	14	vivo	vivo	NOUN
admet-2043	513	15	models	model	NOUN
admet-2043	513	16	,	,	PUNCT
admet-2043	513	17	making	make	VERB
admet-2043	513	18	interpreting	interpret	VERB
admet-2043	513	19	results	result	NOUN
admet-2043	513	20	admet	admet	PROPN
admet-2043	513	21	&	&	CCONJ
admet-2043	513	22	dmpk	dmpk	PROPN
admet-2043	513	23	12(1	12(1	PROPN
admet-2043	513	24	)	)	PUNCT
admet-2043	513	25	(	(	PUNCT
admet-2043	513	26	2024	2024	NUM
admet-2043	513	27	)	)	PUNCT
admet-2043	513	28	63	63	NUM
admet-2043	513	29	-	-	SYM
admet-2043	513	30	105	105	NUM
admet-2043	513	31	nanomaterials	nanomaterial	NOUN
admet-2043	513	32	as	as	ADP
admet-2043	513	33	drug	drug	NOUN
admet-2043	513	34	delivery	delivery	NOUN
admet-2043	513	35	agents	agent	NOUN
admet-2043	513	36	for	for	ADP
admet-2043	513	37	overcoming	overcome	VERB
admet-2043	513	38	bbb	bbb	PROPN
admet-2043	513	39	doi	doi	NOUN
admet-2043	513	40	:	:	PUNCT
admet-2043	513	41	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	513	42	83	83	NUM
admet-2043	513	43	easier	easy	ADJ
admet-2043	513	44	[	[	X
admet-2043	513	45	144	144	NUM
admet-2043	513	46	]	]	PUNCT
admet-2043	513	47	.	.	PUNCT
admet-2043	514	1	one	one	NUM
admet-2043	514	2	such	such	ADJ
admet-2043	514	3	limitation	limitation	NOUN
admet-2043	514	4	of	of	ADP
admet-2043	514	5	this	this	DET
admet-2043	514	6	model	model	NOUN
admet-2043	514	7	is	be	AUX
admet-2043	514	8	the	the	DET
admet-2043	514	9	absence	absence	NOUN
admet-2043	514	10	of	of	ADP
admet-2043	514	11	dynamic	dynamic	ADJ
admet-2043	514	12	fluid	fluid	NOUN
admet-2043	514	13	flow	flow	NOUN
admet-2043	514	14	and	and	CCONJ
admet-2043	514	15	mechanical	mechanical	ADJ
admet-2043	514	16	forces	force	NOUN
admet-2043	514	17	that	that	PRON
admet-2043	514	18	exist	exist	VERB
admet-2043	514	19	in	in	ADP
admet-2043	514	20	vivo	vivo	NOUN
admet-2043	514	21	and	and	CCONJ
admet-2043	514	22	can	can	AUX
admet-2043	514	23	impact	impact	VERB
admet-2043	514	24	cell	cell	NOUN
admet-2043	514	25	behaviour	behaviour	NOUN
admet-2043	514	26	and	and	CCONJ
admet-2043	514	27	drug	drug	NOUN
admet-2043	514	28	transport	transport	NOUN
admet-2043	514	29	[	[	X
admet-2043	514	30	145	145	NUM
admet-2043	514	31	]	]	PUNCT
admet-2043	514	32	.	.	PUNCT
admet-2043	515	1	numerous	numerous	ADJ
admet-2043	515	2	studies	study	NOUN
admet-2043	515	3	have	have	AUX
admet-2043	515	4	employed	employ	VERB
admet-2043	515	5	static	static	NOUN
admet-2043	515	6	in	in	ADP
admet-2043	515	7	vitro	vitro	X
admet-2043	515	8	models	model	NOUN
admet-2043	515	9	to	to	PART
admet-2043	515	10	explore	explore	VERB
admet-2043	515	11	the	the	DET
admet-2043	515	12	capacity	capacity	NOUN
admet-2043	515	13	of	of	ADP
admet-2043	515	14	nms	nms	NOUN
admet-2043	515	15	in	in	ADP
admet-2043	515	16	crossing	cross	VERB
admet-2043	515	17	the	the	DET
admet-2043	515	18	bbb	bbb	PROPN
admet-2043	515	19	.	.	PUNCT
admet-2043	516	1	for	for	ADP
admet-2043	516	2	instance	instance	NOUN
admet-2043	516	3	,	,	PUNCT
admet-2043	516	4	yan	yan	PROPN
admet-2043	516	5	et	et	PROPN
admet-2043	516	6	al	al	PROPN
admet-2043	516	7	.	.	PUNCT
admet-2043	517	1	[	[	X
admet-2043	517	2	146	146	NUM
admet-2043	517	3	]	]	PUNCT
admet-2043	517	4	conducted	conduct	VERB
admet-2043	517	5	research	research	NOUN
admet-2043	517	6	using	use	VERB
admet-2043	517	7	a	a	DET
admet-2043	517	8	static	static	NOUN
admet-2043	517	9	in	in	ADP
admet-2043	517	10	vitro	vitro	X
admet-2043	517	11	bbb	bbb	PROPN
admet-2043	517	12	model	model	NOUN
admet-2043	517	13	to	to	PART
admet-2043	517	14	examine	examine	VERB
admet-2043	517	15	the	the	DET
admet-2043	517	16	uptake	uptake	NOUN
admet-2043	517	17	and	and	CCONJ
admet-2043	517	18	transportation	transportation	NOUN
admet-2043	517	19	of	of	ADP
admet-2043	517	20	curcumin	curcumin	NOUN
admet-2043	517	21	-	-	PUNCT
admet-2043	517	22	containing	contain	VERB
admet-2043	517	23	nanoparticles	nanoparticle	NOUN
admet-2043	517	24	by	by	ADP
admet-2043	517	25	brain	brain	NOUN
admet-2043	517	26	endothelial	endothelial	ADJ
admet-2043	517	27	cells	cell	NOUN
admet-2043	517	28	.	.	PUNCT
admet-2043	518	1	the	the	DET
admet-2043	518	2	findings	finding	NOUN
admet-2043	518	3	suggested	suggest	VERB
admet-2043	518	4	that	that	SCONJ
admet-2043	518	5	the	the	DET
admet-2043	518	6	nms	nms	NOUN
admet-2043	518	7	could	could	AUX
admet-2043	518	8	traverse	traverse	VERB
admet-2043	518	9	the	the	DET
admet-2043	518	10	bbb	bbb	NOUN
admet-2043	518	11	and	and	CCONJ
admet-2043	518	12	gather	gather	VERB
admet-2043	518	13	in	in	ADP
admet-2043	518	14	the	the	DET
admet-2043	518	15	brain	brain	NOUN
admet-2043	518	16	tissue	tissue	NOUN
admet-2043	518	17	,	,	PUNCT
admet-2043	518	18	indicating	indicate	VERB
admet-2043	518	19	their	their	PRON
admet-2043	518	20	potential	potential	NOUN
admet-2043	518	21	as	as	ADP
admet-2043	518	22	an	an	DET
admet-2043	518	23	efficient	efficient	ADJ
admet-2043	518	24	drug	drug	NOUN
admet-2043	518	25	delivery	delivery	NOUN
admet-2043	518	26	system	system	NOUN
admet-2043	518	27	for	for	ADP
admet-2043	518	28	treating	treat	VERB
admet-2043	518	29	neurological	neurological	ADJ
admet-2043	518	30	disorders	disorder	NOUN
admet-2043	518	31	.	.	PUNCT
admet-2043	519	1	microfluidic	microfluidic	ADJ
admet-2043	519	2	devices	device	NOUN
admet-2043	519	3	provide	provide	VERB
admet-2043	519	4	a	a	DET
admet-2043	519	5	more	more	ADV
admet-2043	519	6	realistic	realistic	ADJ
admet-2043	519	7	in	in	ADP
admet-2043	519	8	vitro	vitro	X
admet-2043	519	9	bbb	bbb	PROPN
admet-2043	519	10	modelling	model	VERB
admet-2043	519	11	platform	platform	NOUN
admet-2043	519	12	by	by	ADP
admet-2043	519	13	incorporating	incorporate	VERB
admet-2043	519	14	various	various	ADJ
admet-2043	519	15	cell	cell	NOUN
admet-2043	519	16	types	type	NOUN
admet-2043	519	17	and	and	CCONJ
admet-2043	519	18	emulating	emulate	VERB
admet-2043	519	19	the	the	DET
admet-2043	519	20	fluid	fluid	ADJ
admet-2043	519	21	dynamics	dynamic	NOUN
admet-2043	519	22	of	of	ADP
admet-2043	519	23	the	the	DET
admet-2043	519	24	brain	brain	NOUN
admet-2043	519	25	.	.	PUNCT
admet-2043	520	1	these	these	DET
admet-2043	520	2	devices	device	NOUN
admet-2043	520	3	enable	enable	VERB
admet-2043	520	4	the	the	DET
admet-2043	520	5	simultaneous	simultaneous	ADJ
admet-2043	520	6	culture	culture	NOUN
admet-2043	520	7	of	of	ADP
admet-2043	520	8	bmecs	bmecs	PROPN
admet-2043	520	9	with	with	ADP
admet-2043	520	10	other	other	ADJ
admet-2043	520	11	cells	cell	NOUN
admet-2043	520	12	,	,	PUNCT
admet-2043	520	13	such	such	ADJ
admet-2043	520	14	as	as	ADP
admet-2043	520	15	astrocytes	astrocyte	NOUN
admet-2043	520	16	and	and	CCONJ
admet-2043	520	17	neurons	neuron	NOUN
admet-2043	520	18	,	,	PUNCT
admet-2043	520	19	in	in	ADP
admet-2043	520	20	a	a	DET
admet-2043	520	21	precisely	precisely	ADV
admet-2043	520	22	controlled	control	VERB
admet-2043	520	23	microenvironment	microenvironment	NOUN
admet-2043	520	24	that	that	SCONJ
admet-2043	520	25	closely	closely	ADV
admet-2043	520	26	resembles	resemble	VERB
admet-2043	520	27	the	the	DET
admet-2043	520	28	structure	structure	NOUN
admet-2043	520	29	and	and	CCONJ
admet-2043	520	30	function	function	NOUN
admet-2043	520	31	of	of	ADP
admet-2043	520	32	the	the	DET
admet-2043	520	33	bbb	bbb	NOUN
admet-2043	521	1	[	[	X
admet-2043	521	2	147	147	NUM
admet-2043	521	3	]	]	PUNCT
admet-2043	521	4	.	.	PUNCT
admet-2043	522	1	microfluidic	microfluidic	ADJ
admet-2043	522	2	devices	device	NOUN
admet-2043	522	3	have	have	AUX
admet-2043	522	4	been	be	AUX
admet-2043	522	5	employed	employ	VERB
admet-2043	522	6	to	to	PART
admet-2043	522	7	investigate	investigate	VERB
admet-2043	522	8	the	the	DET
admet-2043	522	9	permeability	permeability	NOUN
admet-2043	522	10	of	of	ADP
admet-2043	522	11	nanoparticles	nanoparticle	NOUN
admet-2043	522	12	across	across	ADP
admet-2043	522	13	the	the	DET
admet-2043	522	14	bbb	bbb	NOUN
admet-2043	522	15	,	,	PUNCT
admet-2043	522	16	assess	assess	VERB
admet-2043	522	17	the	the	DET
admet-2043	522	18	toxicity	toxicity	NOUN
admet-2043	522	19	of	of	ADP
admet-2043	522	20	nms	nms	NOUN
admet-2043	522	21	on	on	ADP
admet-2043	522	22	bbb	bbb	PROPN
admet-2043	522	23	endothelial	endothelial	ADJ
admet-2043	522	24	cells	cell	NOUN
admet-2043	522	25	,	,	PUNCT
admet-2043	522	26	and	and	CCONJ
admet-2043	522	27	screen	screen	NOUN
admet-2043	522	28	promising	promise	VERB
admet-2043	522	29	drugs	drug	NOUN
admet-2043	522	30	for	for	ADP
admet-2043	522	31	their	their	PRON
admet-2043	522	32	ability	ability	NOUN
admet-2043	522	33	to	to	PART
admet-2043	522	34	cross	cross	VERB
admet-2043	522	35	the	the	DET
admet-2043	522	36	bbb	bbb	NOUN
admet-2043	523	1	[	[	X
admet-2043	523	2	148	148	NUM
admet-2043	523	3	]	]	PUNCT
admet-2043	523	4	.	.	PUNCT
admet-2043	524	1	to	to	PART
admet-2043	524	2	investigate	investigate	VERB
admet-2043	524	3	the	the	DET
admet-2043	524	4	potential	potential	NOUN
admet-2043	524	5	of	of	ADP
admet-2043	524	6	nanomaterials	nanomaterial	NOUN
admet-2043	524	7	for	for	ADP
admet-2043	524	8	drug	drug	NOUN
admet-2043	524	9	delivery	delivery	NOUN
admet-2043	524	10	to	to	ADP
admet-2043	524	11	the	the	DET
admet-2043	524	12	brain	brain	NOUN
admet-2043	524	13	,	,	PUNCT
admet-2043	524	14	various	various	ADJ
admet-2043	524	15	models	model	NOUN
admet-2043	524	16	have	have	AUX
admet-2043	524	17	been	be	AUX
admet-2043	524	18	utilized	utilize	VERB
admet-2043	524	19	,	,	PUNCT
admet-2043	524	20	including	include	VERB
admet-2043	524	21	cell	cell	NOUN
admet-2043	524	22	-	-	PUNCT
admet-2043	524	23	based	base	VERB
admet-2043	524	24	models	model	NOUN
admet-2043	524	25	and	and	CCONJ
admet-2043	524	26	microfluidic	microfluidic	ADJ
admet-2043	524	27	devices	device	NOUN
admet-2043	524	28	.	.	PUNCT
admet-2043	525	1	these	these	DET
admet-2043	525	2	models	model	NOUN
admet-2043	525	3	provide	provide	VERB
admet-2043	525	4	a	a	DET
admet-2043	525	5	means	mean	NOUN
admet-2043	525	6	to	to	PART
admet-2043	525	7	comprehend	comprehend	VERB
admet-2043	525	8	the	the	DET
admet-2043	525	9	mechanism	mechanism	NOUN
admet-2043	525	10	of	of	ADP
admet-2043	525	11	nanoparticle	nanoparticle	NOUN
admet-2043	525	12	transport	transport	NOUN
admet-2043	525	13	,	,	PUNCT
admet-2043	525	14	assess	assess	VERB
admet-2043	525	15	the	the	DET
admet-2043	525	16	safety	safety	NOUN
admet-2043	525	17	of	of	ADP
admet-2043	525	18	nanomaterials	nanomaterial	NOUN
admet-2043	525	19	,	,	PUNCT
admet-2043	525	20	and	and	CCONJ
admet-2043	525	21	screen	screen	NOUN
admet-2043	525	22	for	for	ADP
admet-2043	525	23	potential	potential	ADJ
admet-2043	525	24	drug	drug	NOUN
admet-2043	525	25	candidates	candidate	NOUN
admet-2043	525	26	.	.	PUNCT
admet-2043	526	1	a	a	DET
admet-2043	526	2	study	study	NOUN
admet-2043	526	3	by	by	ADP
admet-2043	526	4	t.	t.	PROPN
admet-2043	526	5	d.	d.	PROPN
admet-2043	526	6	brown	brown	PROPN
admet-2043	526	7	et	et	PROPN
admet-2043	526	8	al	al	PROPN
admet-2043	526	9	.	.	PUNCT
admet-2043	527	1	[	[	X
admet-2043	527	2	149	149	NUM
admet-2043	527	3	]	]	PUNCT
admet-2043	527	4	utilized	utilize	VERB
admet-2043	527	5	a	a	DET
admet-2043	527	6	microfluidic	microfluidic	ADJ
admet-2043	527	7	device	device	NOUN
admet-2043	527	8	to	to	PART
admet-2043	527	9	examine	examine	VERB
admet-2043	527	10	the	the	DET
admet-2043	527	11	ability	ability	NOUN
admet-2043	527	12	of	of	ADP
admet-2043	527	13	nanocarriers	nanocarrier	NOUN
admet-2043	527	14	to	to	PART
admet-2043	527	15	cross	cross	VERB
admet-2043	527	16	the	the	DET
admet-2043	527	17	bbb	bbb	PROPN
admet-2043	527	18	.	.	PUNCT
admet-2043	528	1	the	the	DET
admet-2043	528	2	microfluidic	microfluidic	ADJ
admet-2043	528	3	device	device	NOUN
admet-2043	528	4	consisted	consist	VERB
admet-2043	528	5	of	of	ADP
admet-2043	528	6	two	two	NUM
admet-2043	528	7	compartments	compartment	NOUN
admet-2043	528	8	separated	separate	VERB
admet-2043	528	9	by	by	ADP
admet-2043	528	10	a	a	DET
admet-2043	528	11	permeable	permeable	ADJ
admet-2043	528	12	membrane	membrane	NOUN
admet-2043	528	13	coated	coat	VERB
admet-2043	528	14	with	with	ADP
admet-2043	528	15	astrocytes	astrocyte	NOUN
admet-2043	528	16	to	to	PART
admet-2043	528	17	replicate	replicate	VERB
admet-2043	528	18	the	the	DET
admet-2043	528	19	bbb	bbb	PROPN
admet-2043	528	20	structure	structure	NOUN
admet-2043	528	21	.	.	PUNCT
admet-2043	529	1	one	one	NUM
admet-2043	529	2	side	side	NOUN
admet-2043	529	3	of	of	ADP
admet-2043	529	4	the	the	DET
admet-2043	529	5	membrane	membrane	NOUN
admet-2043	529	6	was	be	AUX
admet-2043	529	7	cultured	cultured	ADJ
admet-2043	529	8	with	with	ADP
admet-2043	529	9	brain	brain	NOUN
admet-2043	529	10	endothelial	endothelial	ADJ
admet-2043	529	11	cells	cell	NOUN
admet-2043	529	12	,	,	PUNCT
admet-2043	529	13	and	and	CCONJ
admet-2043	529	14	nms	nms	PROPN
admet-2043	529	15	were	be	AUX
admet-2043	529	16	introduced	introduce	VERB
admet-2043	529	17	to	to	ADP
admet-2043	529	18	the	the	DET
admet-2043	529	19	other	other	ADJ
admet-2043	529	20	.	.	PUNCT
admet-2043	530	1	the	the	DET
admet-2043	530	2	study	study	NOUN
admet-2043	530	3	found	find	VERB
admet-2043	530	4	that	that	SCONJ
admet-2043	530	5	the	the	DET
admet-2043	530	6	transport	transport	NOUN
admet-2043	530	7	efficiency	efficiency	NOUN
admet-2043	530	8	of	of	ADP
admet-2043	530	9	nanoparticles	nanoparticle	NOUN
admet-2043	530	10	across	across	ADP
admet-2043	530	11	the	the	DET
admet-2043	530	12	bbb	bbb	NOUN
admet-2043	530	13	was	be	AUX
admet-2043	530	14	affected	affect	VERB
admet-2043	530	15	by	by	ADP
admet-2043	530	16	their	their	PRON
admet-2043	530	17	size	size	NOUN
admet-2043	530	18	and	and	CCONJ
admet-2043	530	19	surface	surface	NOUN
admet-2043	530	20	charge	charge	NOUN
admet-2043	530	21	,	,	PUNCT
admet-2043	530	22	and	and	CCONJ
admet-2043	530	23	the	the	DET
admet-2043	530	24	presence	presence	NOUN
admet-2043	530	25	of	of	ADP
admet-2043	530	26	astrocytes	astrocyte	NOUN
admet-2043	530	27	improved	improve	VERB
admet-2043	530	28	their	their	PRON
admet-2043	530	29	transport	transport	NOUN
admet-2043	530	30	efficacy	efficacy	NOUN
admet-2043	530	31	.	.	PUNCT
admet-2043	531	1	this	this	DET
admet-2043	531	2	article	article	NOUN
admet-2043	531	3	highlights	highlight	VERB
admet-2043	531	4	the	the	DET
admet-2043	531	5	potential	potential	NOUN
admet-2043	531	6	of	of	ADP
admet-2043	531	7	microfluidic	microfluidic	ADJ
admet-2043	531	8	devices	device	NOUN
admet-2043	531	9	as	as	ADP
admet-2043	531	10	a	a	DET
admet-2043	531	11	valuable	valuable	ADJ
admet-2043	531	12	tool	tool	NOUN
admet-2043	531	13	for	for	ADP
admet-2043	531	14	understanding	understand	VERB
admet-2043	531	15	the	the	DET
admet-2043	531	16	mechanism	mechanism	NOUN
admet-2043	531	17	of	of	ADP
admet-2043	531	18	nanoparticle	nanoparticle	NOUN
admet-2043	531	19	transport	transport	NOUN
admet-2043	531	20	across	across	ADP
admet-2043	531	21	the	the	DET
admet-2043	531	22	bbb	bbb	NOUN
admet-2043	531	23	and	and	CCONJ
admet-2043	531	24	developing	develop	VERB
admet-2043	531	25	effective	effective	ADJ
admet-2043	531	26	drug	drug	NOUN
admet-2043	531	27	delivery	delivery	NOUN
admet-2043	531	28	[	[	X
admet-2043	531	29	150	150	NUM
admet-2043	531	30	]	]	PUNCT
admet-2043	531	31	strategies	strategy	NOUN
admet-2043	531	32	for	for	ADP
admet-2043	531	33	the	the	DET
admet-2043	531	34	treatment	treatment	NOUN
admet-2043	531	35	of	of	ADP
admet-2043	531	36	neurological	neurological	ADJ
admet-2043	531	37	disorders	disorder	NOUN
admet-2043	531	38	[	[	X
admet-2043	531	39	149	149	NUM
admet-2043	531	40	]	]	PUNCT
admet-2043	531	41	.	.	PUNCT
admet-2043	532	1	one	one	NUM
admet-2043	532	2	example	example	NOUN
admet-2043	532	3	of	of	ADP
admet-2043	532	4	a	a	DET
admet-2043	532	5	dynamic	dynamic	NOUN
admet-2043	532	6	in	in	ADP
admet-2043	532	7	vitro	vitro	X
admet-2043	532	8	model	model	NOUN
admet-2043	532	9	is	be	AUX
admet-2043	532	10	a	a	DET
admet-2043	532	11	microfluidic	microfluidic	NOUN
admet-2043	532	12	-	-	PUNCT
admet-2043	532	13	on	on	ADP
admet-2043	532	14	-	-	PUNCT
admet-2043	532	15	a	a	DET
admet-2043	532	16	-	-	PUNCT
admet-2043	532	17	chip	chip	NOUN
admet-2043	532	18	system	system	NOUN
admet-2043	532	19	.	.	PUNCT
admet-2043	533	1	this	this	DET
admet-2043	533	2	type	type	NOUN
admet-2043	533	3	of	of	ADP
admet-2043	533	4	laboratory	laboratory	NOUN
admet-2043	533	5	model	model	NOUN
admet-2043	533	6	is	be	AUX
admet-2043	533	7	made	make	VERB
admet-2043	533	8	by	by	ADP
admet-2043	533	9	designing	design	VERB
admet-2043	533	10	tiny	tiny	ADJ
admet-2043	533	11	channels	channel	NOUN
admet-2043	533	12	on	on	ADP
admet-2043	533	13	a	a	DET
admet-2043	533	14	microchip	microchip	NOUN
admet-2043	533	15	[	[	X
admet-2043	533	16	147	147	NUM
admet-2043	533	17	]	]	PUNCT
admet-2043	533	18	.	.	PUNCT
admet-2043	534	1	these	these	DET
admet-2043	534	2	models	model	NOUN
admet-2043	534	3	have	have	VERB
admet-2043	534	4	many	many	ADJ
admet-2043	534	5	benefits	benefit	NOUN
admet-2043	534	6	,	,	PUNCT
admet-2043	534	7	like	like	ADP
admet-2043	534	8	being	be	AUX
admet-2043	534	9	more	more	ADV
admet-2043	534	10	like	like	ADP
admet-2043	534	11	real	real	ADJ
admet-2043	534	12	life	life	NOUN
admet-2043	534	13	and	and	CCONJ
admet-2043	534	14	helping	help	VERB
admet-2043	534	15	us	we	PRON
admet-2043	534	16	learn	learn	VERB
admet-2043	534	17	more	more	ADJ
admet-2043	534	18	about	about	ADP
admet-2043	534	19	the	the	DET
admet-2043	534	20	bbb	bbb	NOUN
admet-2043	534	21	and	and	CCONJ
admet-2043	534	22	how	how	SCONJ
admet-2043	534	23	to	to	PART
admet-2043	534	24	deliver	deliver	VERB
admet-2043	534	25	drugs	drug	NOUN
admet-2043	534	26	to	to	ADP
admet-2043	534	27	the	the	DET
admet-2043	534	28	brain	brain	NOUN
admet-2043	534	29	.	.	PUNCT
admet-2043	535	1	they	they	PRON
admet-2043	535	2	can	can	AUX
admet-2043	535	3	mimic	mimic	VERB
admet-2043	535	4	complex	complex	ADJ
admet-2043	535	5	shapes	shape	NOUN
admet-2043	535	6	and	and	CCONJ
admet-2043	535	7	movements	movement	NOUN
admet-2043	535	8	in	in	ADP
admet-2043	535	9	the	the	DET
admet-2043	535	10	brain	brain	NOUN
admet-2043	535	11	and	and	CCONJ
admet-2043	535	12	can	can	AUX
admet-2043	535	13	be	be	AUX
admet-2043	535	14	used	use	VERB
admet-2043	535	15	to	to	PART
admet-2043	535	16	test	test	VERB
admet-2043	535	17	many	many	ADJ
admet-2043	535	18	different	different	ADJ
admet-2043	535	19	drugs	drug	NOUN
admet-2043	535	20	simultaneously	simultaneously	ADV
admet-2043	536	1	[	[	X
admet-2043	536	2	151	151	NUM
admet-2043	536	3	]	]	PUNCT
admet-2043	536	4	.	.	PUNCT
admet-2043	537	1	overall	overall	ADJ
admet-2043	537	2	,	,	PUNCT
admet-2043	537	3	dynamic	dynamic	ADJ
admet-2043	537	4	in	in	ADP
admet-2043	537	5	vitro	vitro	X
admet-2043	537	6	models	model	NOUN
admet-2043	537	7	of	of	ADP
admet-2043	537	8	the	the	DET
admet-2043	537	9	bbb	bbb	NOUN
admet-2043	537	10	,	,	PUNCT
admet-2043	537	11	like	like	ADP
admet-2043	537	12	microfluidic	microfluidic	NOUN
admet-2043	537	13	-	-	PUNCT
admet-2043	537	14	on	on	ADP
admet-2043	537	15	-	-	PUNCT
admet-2043	537	16	a	a	DET
admet-2043	537	17	-	-	PUNCT
admet-2043	537	18	chip	chip	NOUN
admet-2043	537	19	systems	system	NOUN
admet-2043	537	20	,	,	PUNCT
admet-2043	537	21	are	be	AUX
admet-2043	537	22	very	very	ADV
admet-2043	537	23	important	important	ADJ
admet-2043	537	24	for	for	ADP
admet-2043	537	25	understanding	understand	VERB
admet-2043	537	26	how	how	SCONJ
admet-2043	537	27	the	the	DET
admet-2043	537	28	brain	brain	NOUN
admet-2043	537	29	works	work	VERB
admet-2043	537	30	and	and	CCONJ
admet-2043	537	31	how	how	SCONJ
admet-2043	537	32	we	we	PRON
admet-2043	537	33	can	can	AUX
admet-2043	537	34	treat	treat	VERB
admet-2043	537	35	diseases	disease	NOUN
admet-2043	537	36	that	that	PRON
admet-2043	537	37	affect	affect	VERB
admet-2043	537	38	the	the	DET
admet-2043	537	39	brain	brain	NOUN
admet-2043	537	40	.	.	PUNCT
admet-2043	538	1	a	a	DET
admet-2043	538	2	study	study	NOUN
admet-2043	538	3	by	by	ADP
admet-2043	538	4	w.	w.	PROPN
admet-2043	538	5	zhang	zhang	PROPN
admet-2043	538	6	et	et	PROPN
admet-2043	538	7	al	al	PROPN
admet-2043	538	8	.	.	PUNCT
admet-2043	539	1	[	[	X
admet-2043	539	2	152	152	NUM
admet-2043	539	3	]	]	PUNCT
admet-2043	539	4	used	use	VERB
admet-2043	539	5	a	a	DET
admet-2043	539	6	microfluidic	microfluidic	ADJ
admet-2043	539	7	bbb	bbb	NOUN
admet-2043	539	8	model	model	NOUN
admet-2043	539	9	to	to	PART
admet-2043	539	10	evaluate	evaluate	VERB
admet-2043	539	11	the	the	DET
admet-2043	539	12	transport	transport	NOUN
admet-2043	539	13	of	of	ADP
admet-2043	539	14	gold	gold	NOUN
admet-2043	539	15	nanoclusters	nanocluster	NOUN
admet-2043	539	16	(	(	PUNCT
admet-2043	539	17	auncs	auncs	PROPN
admet-2043	539	18	)	)	PUNCT
admet-2043	539	19	across	across	ADP
admet-2043	539	20	the	the	DET
admet-2043	539	21	bbb	bbb	NOUN
admet-2043	539	22	for	for	ADP
admet-2043	539	23	potential	potential	ADJ
admet-2043	539	24	drug	drug	NOUN
admet-2043	539	25	delivery	delivery	NOUN
admet-2043	539	26	applications	application	NOUN
admet-2043	539	27	.	.	PUNCT
admet-2043	540	1	the	the	DET
admet-2043	540	2	study	study	NOUN
admet-2043	540	3	used	use	VERB
admet-2043	540	4	a	a	DET
admet-2043	540	5	microfluidic	microfluidic	ADJ
admet-2043	540	6	bbb	bbb	NOUN
admet-2043	540	7	model	model	NOUN
admet-2043	540	8	with	with	ADP
admet-2043	540	9	human	human	ADJ
admet-2043	540	10	brain	brain	NOUN
admet-2043	540	11	microvascular	microvascular	NOUN
admet-2043	540	12	endothelial	endothelial	ADJ
admet-2043	540	13	cells	cell	NOUN
admet-2043	540	14	(	(	PUNCT
admet-2043	540	15	hbmecs	hbmecs	PROPN
admet-2043	540	16	)	)	PUNCT
admet-2043	540	17	and	and	CCONJ
admet-2043	540	18	astrocytes	astrocyte	NOUN
admet-2043	540	19	to	to	PART
admet-2043	540	20	mimic	mimic	VERB
admet-2043	540	21	the	the	DET
admet-2043	540	22	bbb	bbb	NOUN
admet-2043	540	23	and	and	CCONJ
admet-2043	540	24	nvu	nvu	NOUN
admet-2043	540	25	.	.	PUNCT
admet-2043	541	1	auncs	auncs	PROPN
admet-2043	541	2	were	be	AUX
admet-2043	541	3	synthesized	synthesize	VERB
admet-2043	541	4	and	and	CCONJ
admet-2043	541	5	loaded	load	VERB
admet-2043	541	6	with	with	ADP
admet-2043	541	7	the	the	DET
admet-2043	541	8	anti	anti	ADJ
admet-2043	541	9	-	-	ADJ
admet-2043	541	10	cancer	cancer	ADJ
admet-2043	541	11	drug	drug	NOUN
admet-2043	541	12	doxorubicin	doxorubicin	PROPN
admet-2043	541	13	and	and	CCONJ
admet-2043	541	14	introduced	introduce	VERB
admet-2043	541	15	to	to	ADP
admet-2043	541	16	the	the	DET
admet-2043	541	17	bbb	bbb	PROPN
admet-2043	541	18	model	model	NOUN
admet-2043	541	19	.	.	PUNCT
admet-2043	542	1	the	the	DET
admet-2043	542	2	study	study	NOUN
admet-2043	542	3	found	find	VERB
admet-2043	542	4	that	that	SCONJ
admet-2043	542	5	the	the	DET
admet-2043	542	6	auncs	auncs	NOUN
admet-2043	542	7	were	be	AUX
admet-2043	542	8	able	able	ADJ
admet-2043	542	9	to	to	PART
admet-2043	542	10	cross	cross	VERB
admet-2043	542	11	the	the	DET
admet-2043	542	12	bbb	bbb	PROPN
admet-2043	542	13	model	model	NOUN
admet-2043	542	14	and	and	CCONJ
admet-2043	542	15	were	be	AUX
admet-2043	542	16	taken	take	VERB
admet-2043	542	17	up	up	ADP
admet-2043	542	18	by	by	ADP
admet-2043	542	19	the	the	DET
admet-2043	542	20	surrounding	surround	VERB
admet-2043	542	21	astrocytes	astrocyte	NOUN
admet-2043	542	22	,	,	PUNCT
admet-2043	542	23	indicating	indicate	VERB
admet-2043	542	24	their	their	PRON
admet-2043	542	25	potential	potential	NOUN
admet-2043	542	26	as	as	ADP
admet-2043	542	27	drug	drug	NOUN
admet-2043	542	28	-	-	PUNCT
admet-2043	542	29	delivery	delivery	NOUN
admet-2043	542	30	agents	agent	NOUN
admet-2043	542	31	.	.	PUNCT
admet-2043	543	1	the	the	DET
admet-2043	543	2	study	study	NOUN
admet-2043	543	3	demonstrates	demonstrate	VERB
admet-2043	543	4	the	the	DET
admet-2043	543	5	potential	potential	NOUN
admet-2043	543	6	of	of	ADP
admet-2043	543	7	dynamic	dynamic	ADJ
admet-2043	543	8	in	in	ADP
admet-2043	543	9	vitro	vitro	X
admet-2043	543	10	models	model	NOUN
admet-2043	543	11	of	of	ADP
admet-2043	543	12	the	the	DET
admet-2043	543	13	bbb	bbb	PROPN
admet-2043	543	14	,	,	PUNCT
admet-2043	543	15	such	such	ADJ
admet-2043	543	16	as	as	ADP
admet-2043	543	17	microfluidic	microfluidic	ADJ
admet-2043	543	18	bbb	bbb	NOUN
admet-2043	543	19	models	model	NOUN
admet-2043	543	20	,	,	PUNCT
admet-2043	543	21	to	to	PART
admet-2043	543	22	enhance	enhance	VERB
admet-2043	543	23	our	our	PRON
admet-2043	543	24	comprehension	comprehension	NOUN
admet-2043	543	25	of	of	ADP
admet-2043	543	26	nanomaterial	nanomaterial	ADJ
admet-2043	543	27	transport	transport	NOUN
admet-2043	543	28	across	across	ADP
admet-2043	543	29	the	the	DET
admet-2043	543	30	bbb	bbb	NOUN
admet-2043	543	31	and	and	CCONJ
admet-2043	543	32	create	create	VERB
admet-2043	543	33	efficient	efficient	ADJ
admet-2043	543	34	drug	drug	NOUN
admet-2043	543	35	delivery	delivery	NOUN
admet-2043	543	36	systems	system	NOUN
admet-2043	543	37	for	for	ADP
admet-2043	543	38	the	the	DET
admet-2043	543	39	treatment	treatment	NOUN
admet-2043	543	40	of	of	ADP
admet-2043	543	41	neurological	neurological	ADJ
admet-2043	543	42	diseases	disease	NOUN
admet-2043	543	43	[	[	X
admet-2043	543	44	152	152	NUM
admet-2043	543	45	]	]	PUNCT
admet-2043	543	46	.	.	PUNCT
admet-2043	544	1	safety	safety	NOUN
admet-2043	544	2	concerns	concern	NOUN
admet-2043	544	3	of	of	ADP
admet-2043	544	4	nanoparticles	nanoparticle	NOUN
admet-2043	544	5	for	for	ADP
admet-2043	544	6	delivery	delivery	NOUN
admet-2043	544	7	across	across	ADP
admet-2043	544	8	bbb	bbb	PROPN
admet-2043	544	9	nms	nms	PROPN
admet-2043	544	10	offer	offer	VERB
admet-2043	544	11	a	a	DET
admet-2043	544	12	promising	promising	ADJ
admet-2043	544	13	avenue	avenue	NOUN
admet-2043	544	14	for	for	ADP
admet-2043	544	15	delivering	deliver	VERB
admet-2043	544	16	drugs	drug	NOUN
admet-2043	544	17	to	to	ADP
admet-2043	544	18	the	the	DET
admet-2043	544	19	brain	brain	NOUN
admet-2043	544	20	by	by	ADP
admet-2043	544	21	overcoming	overcome	VERB
admet-2043	544	22	the	the	DET
admet-2043	544	23	bbb	bbb	NOUN
admet-2043	544	24	[	[	X
admet-2043	544	25	153	153	NUM
admet-2043	544	26	]	]	PUNCT
admet-2043	544	27	.	.	PUNCT
admet-2043	545	1	however	however	ADV
admet-2043	545	2	,	,	PUNCT
admet-2043	545	3	it	it	PRON
admet-2043	545	4	is	be	AUX
admet-2043	545	5	essential	essential	ADJ
admet-2043	545	6	to	to	PART
admet-2043	545	7	address	address	VERB
admet-2043	545	8	safety	safety	NOUN
admet-2043	545	9	concerns	concern	NOUN
admet-2043	545	10	associated	associate	VERB
admet-2043	545	11	with	with	ADP
admet-2043	545	12	the	the	DET
admet-2043	545	13	use	use	NOUN
admet-2043	545	14	of	of	ADP
admet-2043	545	15	nanomaterials	nanomaterial	NOUN
admet-2043	545	16	for	for	ADP
admet-2043	545	17	drug	drug	NOUN
admet-2043	545	18	delivery	delivery	NOUN
admet-2043	545	19	.	.	PUNCT
admet-2043	546	1	in	in	ADP
admet-2043	546	2	this	this	DET
admet-2043	546	3	topic	topic	NOUN
admet-2043	546	4	,	,	PUNCT
admet-2043	546	5	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	546	6	m.	m.	NOUN
admet-2043	546	7	kulkarni	kulkarni	PROPN
admet-2043	546	8	et	et	PROPN
admet-2043	546	9	al	al	PROPN
admet-2043	546	10	.	.	PROPN
admet-2043	546	11	admet	admet	PROPN
admet-2043	546	12	&	&	CCONJ
admet-2043	546	13	dmpk	dmpk	PROPN
admet-2043	546	14	12(1	12(1	PROPN
admet-2043	546	15	)	)	PUNCT
admet-2043	546	16	(	(	PUNCT
admet-2043	546	17	2024	2024	NUM
admet-2043	546	18	)	)	PUNCT
admet-2043	546	19	63	63	NUM
admet-2043	546	20	-	-	SYM
admet-2043	546	21	105	105	NUM
admet-2043	546	22	84	84	NUM
admet-2043	546	23	we	we	PRON
admet-2043	546	24	will	will	AUX
admet-2043	546	25	examine	examine	VERB
admet-2043	546	26	the	the	DET
admet-2043	546	27	safety	safety	NOUN
admet-2043	546	28	considerations	consideration	NOUN
admet-2043	546	29	of	of	ADP
admet-2043	546	30	nanomaterials	nanomaterial	NOUN
admet-2043	546	31	as	as	ADP
admet-2043	546	32	drug	drug	NOUN
admet-2043	546	33	carriers	carrier	NOUN
admet-2043	546	34	for	for	ADP
admet-2043	546	35	crossing	cross	VERB
admet-2043	546	36	the	the	DET
admet-2043	546	37	bbb	bbb	PROPN
admet-2043	546	38	,	,	PUNCT
admet-2043	546	39	emphasizing	emphasize	VERB
admet-2043	546	40	the	the	DET
admet-2043	546	41	importance	importance	NOUN
admet-2043	546	42	of	of	ADP
admet-2043	546	43	evaluating	evaluate	VERB
admet-2043	546	44	and	and	CCONJ
admet-2043	546	45	minimizing	minimize	VERB
admet-2043	546	46	potential	potential	ADJ
admet-2043	546	47	harm	harm	NOUN
admet-2043	546	48	while	while	SCONJ
admet-2043	546	49	maximizing	maximize	VERB
admet-2043	546	50	therapeutic	therapeutic	ADJ
admet-2043	546	51	benefits	benefit	NOUN
admet-2043	546	52	.	.	PUNCT
admet-2043	547	1	physicochemical	physicochemical	ADJ
admet-2043	547	2	properties	property	NOUN
admet-2043	547	3	and	and	CCONJ
admet-2043	547	4	potential	potential	ADJ
admet-2043	547	5	toxicity	toxicity	NOUN
admet-2043	547	6	nms	nms	NOUN
admet-2043	547	7	possess	possess	VERB
admet-2043	547	8	unique	unique	ADJ
admet-2043	547	9	physicochemical	physicochemical	ADJ
admet-2043	547	10	properties	property	NOUN
admet-2043	547	11	that	that	PRON
admet-2043	547	12	make	make	VERB
admet-2043	547	13	them	they	PRON
admet-2043	547	14	promising	promise	VERB
admet-2043	547	15	candidates	candidate	NOUN
admet-2043	547	16	for	for	ADP
admet-2043	547	17	drug	drug	NOUN
admet-2043	547	18	delivery	delivery	NOUN
admet-2043	547	19	to	to	ADP
admet-2043	547	20	the	the	DET
admet-2043	547	21	brain	brain	NOUN
admet-2043	547	22	.	.	PUNCT
admet-2043	548	1	manipulating	manipulate	VERB
admet-2043	548	2	their	their	PRON
admet-2043	548	3	size	size	NOUN
admet-2043	548	4	,	,	PUNCT
admet-2043	548	5	shape	shape	NOUN
admet-2043	548	6	,	,	PUNCT
admet-2043	548	7	composition	composition	NOUN
admet-2043	548	8	,	,	PUNCT
admet-2043	548	9	and	and	CCONJ
admet-2043	548	10	surface	surface	NOUN
admet-2043	548	11	charge	charge	NOUN
admet-2043	548	12	can	can	AUX
admet-2043	548	13	enhance	enhance	VERB
admet-2043	548	14	their	their	PRON
admet-2043	548	15	ability	ability	NOUN
admet-2043	548	16	to	to	PART
admet-2043	548	17	penetrate	penetrate	VERB
admet-2043	548	18	the	the	DET
admet-2043	548	19	bbb	bbb	PROPN
admet-2043	548	20	.	.	PUNCT
admet-2043	549	1	however	however	ADV
admet-2043	549	2	,	,	PUNCT
admet-2043	549	3	it	it	PRON
admet-2043	549	4	is	be	AUX
admet-2043	549	5	crucial	crucial	ADJ
admet-2043	549	6	to	to	PART
admet-2043	549	7	carefully	carefully	ADV
admet-2043	549	8	evaluate	evaluate	VERB
admet-2043	549	9	the	the	DET
admet-2043	549	10	potential	potential	ADJ
admet-2043	549	11	toxicity	toxicity	NOUN
admet-2043	549	12	of	of	ADP
admet-2043	549	13	these	these	DET
admet-2043	549	14	nms	nms	NOUN
admet-2043	549	15	to	to	PART
admet-2043	549	16	ensure	ensure	VERB
admet-2043	549	17	their	their	PRON
admet-2043	549	18	safe	safe	ADJ
admet-2043	549	19	application	application	NOUN
admet-2043	549	20	[	[	X
admet-2043	549	21	154	154	NUM
admet-2043	549	22	]	]	PUNCT
admet-2043	549	23	.	.	PUNCT
admet-2043	550	1	understanding	understand	VERB
admet-2043	550	2	the	the	DET
admet-2043	550	3	relationships	relationship	NOUN
admet-2043	550	4	between	between	ADP
admet-2043	550	5	physicochemical	physicochemical	ADJ
admet-2043	550	6	properties	property	NOUN
admet-2043	550	7	and	and	CCONJ
admet-2043	550	8	toxicity	toxicity	NOUN
admet-2043	550	9	will	will	AUX
admet-2043	550	10	facilitate	facilitate	VERB
admet-2043	550	11	the	the	DET
admet-2043	550	12	development	development	NOUN
admet-2043	550	13	of	of	ADP
admet-2043	550	14	effective	effective	ADJ
admet-2043	550	15	and	and	CCONJ
admet-2043	550	16	safe	safe	ADJ
admet-2043	550	17	nanomaterial	nanomaterial	NOUN
admet-2043	550	18	-	-	PUNCT
admet-2043	550	19	based	base	VERB
admet-2043	550	20	drug	drug	NOUN
admet-2043	550	21	delivery	delivery	NOUN
admet-2043	550	22	systems	system	NOUN
admet-2043	550	23	for	for	ADP
admet-2043	550	24	the	the	DET
admet-2043	550	25	brain	brain	NOUN
admet-2043	550	26	.	.	PUNCT
admet-2043	551	1	size	size	NOUN
admet-2043	551	2	-	-	PUNCT
admet-2043	551	3	dependent	dependent	ADJ
admet-2043	551	4	:	:	PUNCT
admet-2043	551	5	the	the	DET
admet-2043	551	6	influence	influence	NOUN
admet-2043	551	7	of	of	ADP
admet-2043	551	8	nanoparticle	nanoparticle	NOUN
admet-2043	551	9	size	size	NOUN
admet-2043	551	10	on	on	ADP
admet-2043	551	11	their	their	PRON
admet-2043	551	12	transport	transport	NOUN
admet-2043	551	13	across	across	ADP
admet-2043	551	14	the	the	DET
admet-2043	551	15	bbb	bbb	NOUN
admet-2043	551	16	and	and	CCONJ
admet-2043	551	17	potential	potential	ADJ
admet-2043	551	18	toxicity	toxicity	NOUN
admet-2043	551	19	is	be	AUX
admet-2043	551	20	significant	significant	ADJ
admet-2043	551	21	.	.	PUNCT
admet-2043	552	1	it	it	PRON
admet-2043	552	2	is	be	AUX
admet-2043	552	3	believed	believe	VERB
admet-2043	552	4	that	that	SCONJ
admet-2043	552	5	surface	surface	NOUN
admet-2043	552	6	-	-	PUNCT
admet-2043	552	7	coated	coat	VERB
admet-2043	552	8	nms	nms	NOUN
admet-2043	552	9	,	,	PUNCT
admet-2043	552	10	resembling	resemble	VERB
admet-2043	552	11	ldl	ldl	NOUN
admet-2043	552	12	(	(	PUNCT
admet-2043	552	13	low	low	ADJ
admet-2043	552	14	-	-	PUNCT
admet-2043	552	15	density	density	NOUN
admet-2043	552	16	lipoprotein	lipoprotein	NOUN
admet-2043	552	17	)	)	PUNCT
admet-2043	552	18	,	,	PUNCT
admet-2043	552	19	utilize	utilize	VERB
admet-2043	552	20	receptor	receptor	NOUN
admet-2043	552	21	-	-	PUNCT
admet-2043	552	22	mediated	mediate	VERB
admet-2043	552	23	mechanisms	mechanism	NOUN
admet-2043	552	24	to	to	PART
admet-2043	552	25	cross	cross	VERB
admet-2043	552	26	the	the	DET
admet-2043	552	27	bbb	bbb	NOUN
admet-2043	553	1	[	[	X
admet-2043	553	2	155	155	NUM
admet-2043	553	3	]	]	PUNCT
admet-2043	553	4	.	.	PUNCT
admet-2043	554	1	polysorbate	polysorbate	NOUN
admet-2043	554	2	80	80	NUM
admet-2043	554	3	acts	act	NOUN
admet-2043	554	4	as	as	ADP
admet-2043	554	5	a	a	DET
admet-2043	554	6	link	link	NOUN
admet-2043	554	7	between	between	ADP
admet-2043	554	8	nms	nms	PROPN
admet-2043	554	9	and	and	CCONJ
admet-2043	554	10	apolipoproteins	apolipoprotein	NOUN
admet-2043	554	11	,	,	PUNCT
admet-2043	554	12	particularly	particularly	ADV
admet-2043	554	13	apoe	apoe	ADJ
admet-2043	554	14	(	(	PUNCT
admet-2043	554	15	apolipoprotein	apolipoprotein	ADJ
admet-2043	554	16	e	e	NOUN
admet-2043	554	17	)	)	PUNCT
admet-2043	554	18	,	,	PUNCT
admet-2043	554	19	promoting	promote	VERB
admet-2043	554	20	ldl	ldl	NOUN
admet-2043	554	21	receptor	receptor	NOUN
admet-2043	554	22	-	-	PUNCT
admet-2043	554	23	mediated	mediate	VERB
admet-2043	554	24	transcytosis	transcytosis	NOUN
admet-2043	554	25	[	[	X
admet-2043	554	26	156	156	NUM
admet-2043	554	27	]	]	PUNCT
admet-2043	554	28	.	.	PUNCT
admet-2043	555	1	nms	nms	NOUN
admet-2043	555	2	with	with	ADP
admet-2043	555	3	sizes	size	NOUN
admet-2043	555	4	similar	similar	ADJ
admet-2043	555	5	to	to	ADP
admet-2043	555	6	ldl	ldl	VERB
admet-2043	555	7	(	(	PUNCT
admet-2043	555	8	around	around	ADV
admet-2043	555	9	20	20	NUM
admet-2043	555	10	-	-	SYM
admet-2043	555	11	25	25	NUM
admet-2043	555	12	nm	nm	NOUN
admet-2043	555	13	)	)	PUNCT
admet-2043	555	14	have	have	AUX
admet-2043	555	15	shown	show	VERB
admet-2043	555	16	optimal	optimal	ADJ
admet-2043	555	17	effectiveness	effectiveness	NOUN
admet-2043	555	18	in	in	ADP
admet-2043	555	19	drug	drug	NOUN
admet-2043	555	20	delivery	delivery	NOUN
admet-2043	555	21	across	across	ADP
admet-2043	555	22	the	the	DET
admet-2043	555	23	bbb	bbb	PROPN
admet-2043	555	24	.	.	PUNCT
admet-2043	556	1	smaller	small	ADJ
admet-2043	556	2	nms	nms	NOUN
admet-2043	556	3	tend	tend	VERB
admet-2043	556	4	to	to	PART
admet-2043	556	5	degrade	degrade	VERB
admet-2043	556	6	more	more	ADV
admet-2043	556	7	rapidly	rapidly	ADV
admet-2043	556	8	within	within	ADP
admet-2043	556	9	endothelial	endothelial	ADJ
admet-2043	556	10	cells	cell	NOUN
admet-2043	556	11	,	,	PUNCT
admet-2043	556	12	leading	lead	VERB
admet-2043	556	13	to	to	ADP
admet-2043	556	14	a	a	DET
admet-2043	556	15	faster	fast	ADJ
admet-2043	556	16	drug	drug	NOUN
admet-2043	556	17	release	release	NOUN
admet-2043	556	18	into	into	ADP
admet-2043	556	19	the	the	DET
admet-2043	556	20	brain	brain	NOUN
admet-2043	556	21	.	.	PUNCT
admet-2043	557	1	thus	thus	ADV
admet-2043	557	2	,	,	PUNCT
admet-2043	557	3	nanoparticle	nanoparticle	NOUN
admet-2043	557	4	size	size	NOUN
admet-2043	557	5	is	be	AUX
admet-2043	557	6	crucial	crucial	ADJ
admet-2043	557	7	in	in	ADP
admet-2043	557	8	drug	drug	NOUN
admet-2043	557	9	delivery	delivery	NOUN
admet-2043	557	10	to	to	ADP
admet-2043	557	11	the	the	DET
admet-2043	557	12	brain	brain	NOUN
admet-2043	558	1	[	[	X
admet-2043	558	2	157	157	NUM
admet-2043	558	3	]	]	PUNCT
admet-2043	558	4	.	.	PUNCT
admet-2043	559	1	surface	surface	NOUN
admet-2043	559	2	charge	charge	NOUN
admet-2043	559	3	:	:	PUNCT
admet-2043	559	4	in	in	ADP
admet-2043	559	5	addition	addition	NOUN
admet-2043	559	6	to	to	ADP
admet-2043	559	7	the	the	DET
admet-2043	559	8	physical	physical	ADJ
admet-2043	559	9	properties	property	NOUN
admet-2043	559	10	of	of	ADP
admet-2043	559	11	endothelial	endothelial	ADJ
admet-2043	559	12	cell	cell	NOUN
admet-2043	559	13	membranes	membrane	NOUN
admet-2043	559	14	and	and	CCONJ
admet-2043	559	15	the	the	DET
admet-2043	559	16	size	size	NOUN
admet-2043	559	17	of	of	ADP
admet-2043	559	18	nms	nms	PROPN
admet-2043	559	19	,	,	PUNCT
admet-2043	559	20	the	the	DET
admet-2043	559	21	surface	surface	NOUN
admet-2043	559	22	charge	charge	NOUN
admet-2043	559	23	of	of	ADP
admet-2043	559	24	nanomaterials	nanomaterial	NOUN
admet-2043	559	25	plays	play	VERB
admet-2043	559	26	a	a	DET
admet-2043	559	27	significant	significant	ADJ
admet-2043	559	28	role	role	NOUN
admet-2043	559	29	in	in	ADP
admet-2043	559	30	their	their	PRON
admet-2043	559	31	transport	transport	NOUN
admet-2043	559	32	across	across	ADP
admet-2043	559	33	the	the	DET
admet-2043	559	34	bbb	bbb	PROPN
admet-2043	559	35	.	.	PUNCT
admet-2043	560	1	electrostatic	electrostatic	ADJ
admet-2043	560	2	,	,	PUNCT
admet-2043	560	3	specifically	specifically	ADV
admet-2043	560	4	cationic	cationic	ADJ
admet-2043	560	5	,	,	PUNCT
admet-2043	560	6	can	can	AUX
admet-2043	560	7	interact	interact	VERB
admet-2043	560	8	with	with	ADP
admet-2043	560	9	anionic	anionic	ADJ
admet-2043	560	10	areas	area	NOUN
admet-2043	560	11	on	on	ADP
admet-2043	560	12	the	the	DET
admet-2043	560	13	bbb	bbb	PROPN
admet-2043	560	14	endothelium	endothelium	NOUN
admet-2043	560	15	.	.	PUNCT
admet-2043	561	1	this	this	DET
admet-2043	561	2	interaction	interaction	NOUN
admet-2043	561	3	may	may	AUX
admet-2043	561	4	increase	increase	VERB
admet-2043	561	5	endothelial	endothelial	ADJ
admet-2043	561	6	cell	cell	NOUN
admet-2043	561	7	permeability	permeability	NOUN
admet-2043	561	8	by	by	ADP
admet-2043	561	9	potentially	potentially	ADV
admet-2043	561	10	disrupting	disrupt	VERB
admet-2043	561	11	the	the	DET
admet-2043	561	12	junctions	junction	NOUN
admet-2043	561	13	between	between	ADP
admet-2043	561	14	cells	cell	NOUN
admet-2043	561	15	[	[	X
admet-2043	561	16	158	158	NUM
admet-2043	561	17	]	]	PUNCT
admet-2043	561	18	.	.	PUNCT
admet-2043	562	1	in	in	ADP
admet-2043	562	2	vitro	vitro	X
admet-2043	562	3	studies	study	NOUN
admet-2043	562	4	have	have	AUX
admet-2043	562	5	shown	show	VERB
admet-2043	562	6	that	that	SCONJ
admet-2043	562	7	cationic	cationic	ADJ
admet-2043	562	8	nanoparticles	nanoparticle	NOUN
admet-2043	562	9	have	have	VERB
admet-2043	562	10	higher	high	ADJ
admet-2043	562	11	brain	brain	NOUN
admet-2043	562	12	translocation	translocation	NOUN
admet-2043	562	13	compared	compare	VERB
admet-2043	562	14	to	to	ADP
admet-2043	562	15	anionic	anionic	ADJ
admet-2043	562	16	or	or	CCONJ
admet-2043	562	17	neutral	neutral	ADJ
admet-2043	562	18	nms	nms	NOUN
admet-2043	563	1	[	[	X
admet-2043	563	2	159	159	NUM
admet-2043	563	3	]	]	PUNCT
admet-2043	563	4	.	.	PUNCT
admet-2043	564	1	the	the	DET
admet-2043	564	2	size	size	NOUN
admet-2043	564	3	and	and	CCONJ
admet-2043	564	4	charge	charge	NOUN
admet-2043	564	5	of	of	ADP
admet-2043	564	6	colloidal	colloidal	NOUN
admet-2043	564	7	drug	drug	NOUN
admet-2043	564	8	carriers	carrier	NOUN
admet-2043	564	9	are	be	AUX
admet-2043	564	10	essential	essential	ADJ
admet-2043	564	11	in	in	ADP
admet-2043	564	12	determining	determine	VERB
admet-2043	564	13	their	their	PRON
admet-2043	564	14	ability	ability	NOUN
admet-2043	564	15	to	to	PART
admet-2043	564	16	deliver	deliver	VERB
admet-2043	564	17	drugs	drug	NOUN
admet-2043	564	18	or	or	CCONJ
admet-2043	564	19	nanoparticles	nanoparticle	NOUN
admet-2043	564	20	across	across	ADP
admet-2043	564	21	the	the	DET
admet-2043	564	22	bbb	bbb	NOUN
admet-2043	564	23	or	or	CCONJ
admet-2043	564	24	into	into	ADP
admet-2043	564	25	the	the	DET
admet-2043	564	26	brain	brain	NOUN
admet-2043	564	27	parenchyma	parenchyma	NOUN
admet-2043	564	28	[	[	X
admet-2043	564	29	160	160	NUM
admet-2043	564	30	]	]	PUNCT
admet-2043	564	31	.	.	PUNCT
admet-2043	565	1	however	however	ADV
admet-2043	565	2	,	,	PUNCT
admet-2043	565	3	a	a	DET
admet-2043	565	4	limited	limited	ADJ
admet-2043	565	5	amount	amount	NOUN
admet-2043	565	6	of	of	ADP
admet-2043	565	7	in	in	ADP
admet-2043	565	8	vivo	vivo	ADJ
admet-2043	565	9	data	datum	NOUN
admet-2043	565	10	is	be	AUX
admet-2043	565	11	available	available	ADJ
admet-2043	565	12	regarding	regard	VERB
admet-2043	565	13	the	the	DET
admet-2043	565	14	brain	brain	NOUN
admet-2043	565	15	permeability	permeability	NOUN
admet-2043	565	16	of	of	ADP
admet-2043	565	17	cationic	cationic	ADJ
admet-2043	565	18	nms	nms	NOUN
admet-2043	565	19	.	.	PUNCT
admet-2043	566	1	in	in	ADP
admet-2043	566	2	a	a	DET
admet-2043	566	3	study	study	NOUN
admet-2043	566	4	by	by	ADP
admet-2043	566	5	koziara	koziara	PROPN
admet-2043	566	6	et	et	PROPN
admet-2043	566	7	al	al	PROPN
admet-2043	566	8	.	.	PUNCT
admet-2043	567	1	[	[	X
admet-2043	567	2	161	161	NUM
admet-2043	567	3	]	]	PUNCT
admet-2043	567	4	,	,	PUNCT
admet-2043	567	5	it	it	PRON
admet-2043	567	6	was	be	AUX
admet-2043	567	7	shown	show	VERB
admet-2043	567	8	that	that	SCONJ
admet-2043	567	9	administering	administer	VERB
admet-2043	567	10	negatively	negatively	ADV
admet-2043	567	11	charged	charge	VERB
admet-2043	567	12	nms	nms	NOUN
admet-2043	567	13	to	to	ADP
admet-2043	567	14	animals	animal	NOUN
admet-2043	567	15	at	at	ADP
admet-2043	567	16	doses	dose	NOUN
admet-2043	567	17	between	between	ADP
admet-2043	567	18	100	100	NUM
admet-2043	567	19	and	and	CCONJ
admet-2043	567	20	200	200	NUM
admet-2043	567	21	mg	mg	NOUN
admet-2043	567	22	per	per	ADP
admet-2043	567	23	animal	animal	NOUN
admet-2043	567	24	caused	cause	VERB
admet-2043	567	25	their	their	PRON
admet-2043	567	26	accumulation	accumulation	NOUN
admet-2043	567	27	in	in	ADP
admet-2043	567	28	the	the	DET
admet-2043	567	29	cellular	cellular	ADJ
admet-2043	567	30	matrix	matrix	NOUN
admet-2043	567	31	without	without	ADP
admet-2043	567	32	causing	cause	VERB
admet-2043	567	33	any	any	DET
admet-2043	567	34	apparent	apparent	ADJ
admet-2043	567	35	neurotoxic	neurotoxic	ADJ
admet-2043	567	36	consequences	consequence	NOUN
admet-2043	567	37	.	.	PUNCT
admet-2043	568	1	however	however	ADV
admet-2043	568	2	,	,	PUNCT
admet-2043	568	3	as	as	SCONJ
admet-2043	568	4	demonstrated	demonstrate	VERB
admet-2043	568	5	in	in	ADP
admet-2043	568	6	the	the	DET
admet-2043	568	7	study	study	NOUN
admet-2043	568	8	by	by	ADP
admet-2043	568	9	koziara	koziara	PROPN
admet-2043	568	10	et	et	PROPN
admet-2043	568	11	al	al	PROPN
admet-2043	568	12	.	.	PUNCT
admet-2043	569	1	[	[	X
admet-2043	569	2	161	161	NUM
admet-2043	569	3	]	]	PUNCT
admet-2043	569	4	,	,	PUNCT
admet-2043	569	5	the	the	DET
admet-2043	569	6	amount	amount	NOUN
admet-2043	569	7	of	of	ADP
admet-2043	569	8	bbb	bbb	NOUN
admet-2043	569	9	opening	opening	NOUN
admet-2043	569	10	in	in	ADP
admet-2043	569	11	the	the	DET
admet-2043	569	12	presence	presence	NOUN
admet-2043	569	13	of	of	ADP
admet-2043	569	14	anionic	anionic	ADJ
admet-2043	569	15	nanoparticles	nanoparticle	NOUN
admet-2043	569	16	is	be	AUX
admet-2043	569	17	only	only	ADV
admet-2043	569	18	proportional	proportional	ADJ
admet-2043	569	19	to	to	ADP
admet-2043	569	20	the	the	DET
admet-2043	569	21	free	free	ADJ
admet-2043	569	22	fraction	fraction	NOUN
admet-2043	569	23	of	of	ADP
admet-2043	569	24	nanoparticles	nanoparticle	NOUN
admet-2043	569	25	in	in	ADP
admet-2043	569	26	formulations	formulation	NOUN
admet-2043	569	27	[	[	X
admet-2043	569	28	162	162	NUM
admet-2043	569	29	]	]	PUNCT
admet-2043	569	30	.	.	PUNCT
admet-2043	570	1	therefore	therefore	ADV
admet-2043	570	2	,	,	PUNCT
admet-2043	570	3	further	further	ADJ
admet-2043	570	4	investigations	investigation	NOUN
admet-2043	570	5	are	be	AUX
admet-2043	570	6	required	require	VERB
admet-2043	570	7	to	to	PART
admet-2043	570	8	determine	determine	VERB
admet-2043	570	9	the	the	DET
admet-2043	570	10	optimal	optimal	ADJ
admet-2043	570	11	concentration	concentration	NOUN
admet-2043	570	12	of	of	ADP
admet-2043	570	13	negatively	negatively	ADV
admet-2043	570	14	charged	charge	VERB
admet-2043	570	15	bms	bms	NOUN
admet-2043	570	16	that	that	PRON
admet-2043	570	17	can	can	AUX
admet-2043	570	18	be	be	AUX
admet-2043	570	19	achieved	achieve	VERB
admet-2043	570	20	in	in	ADP
admet-2043	570	21	the	the	DET
admet-2043	570	22	brain	brain	NOUN
admet-2043	570	23	without	without	ADP
admet-2043	570	24	causing	cause	VERB
admet-2043	570	25	any	any	DET
admet-2043	570	26	noticeable	noticeable	ADJ
admet-2043	570	27	neurotoxicity	neurotoxicity	NOUN
admet-2043	570	28	.	.	PUNCT
admet-2043	570	29	shape	shape	NOUN
admet-2043	570	30	-	-	PUNCT
admet-2043	570	31	related	relate	VERB
admet-2043	570	32	toxicity	toxicity	NOUN
admet-2043	570	33	:	:	PUNCT
admet-2043	570	34	nanomaterials	nanomaterial	NOUN
admet-2043	570	35	with	with	ADP
admet-2043	570	36	a	a	DET
admet-2043	570	37	high	high	ADJ
admet-2043	570	38	aspect	aspect	NOUN
admet-2043	570	39	ratio	ratio	NOUN
admet-2043	570	40	,	,	PUNCT
admet-2043	570	41	such	such	ADJ
admet-2043	570	42	as	as	ADP
admet-2043	570	43	nanorods	nanorod	NOUN
admet-2043	570	44	or	or	CCONJ
admet-2043	570	45	nanowires	nanowire	NOUN
admet-2043	570	46	,	,	PUNCT
admet-2043	570	47	have	have	AUX
admet-2043	570	48	been	be	AUX
admet-2043	570	49	found	find	VERB
admet-2043	570	50	to	to	PART
admet-2043	570	51	exhibit	exhibit	VERB
admet-2043	570	52	improved	improved	ADJ
admet-2043	570	53	penetration	penetration	NOUN
admet-2043	570	54	across	across	ADP
admet-2043	570	55	the	the	DET
admet-2043	570	56	bbb	bbb	NOUN
admet-2043	570	57	compared	compare	VERB
admet-2043	570	58	to	to	ADP
admet-2043	570	59	spherical	spherical	ADJ
admet-2043	570	60	nms	nms	NOUN
admet-2043	570	61	.	.	PUNCT
admet-2043	571	1	their	their	PRON
admet-2043	571	2	elongated	elongate	VERB
admet-2043	571	3	shape	shape	NOUN
admet-2043	571	4	enhances	enhance	VERB
admet-2043	571	5	interaction	interaction	NOUN
admet-2043	571	6	with	with	ADP
admet-2043	571	7	bbb	bbb	PROPN
admet-2043	571	8	endothelial	endothelial	ADJ
admet-2043	571	9	cells	cell	NOUN
admet-2043	571	10	,	,	PUNCT
admet-2043	571	11	facilitating	facilitate	VERB
admet-2043	571	12	translocation	translocation	NOUN
admet-2043	571	13	through	through	ADP
admet-2043	571	14	tight	tight	ADJ
admet-2043	571	15	junctions	junction	NOUN
admet-2043	571	16	or	or	CCONJ
admet-2043	571	17	cellular	cellular	ADJ
admet-2043	571	18	uptake	uptake	ADJ
admet-2043	571	19	mechanisms	mechanism	NOUN
admet-2043	571	20	.	.	PUNCT
admet-2043	572	1	similarly	similarly	ADV
admet-2043	572	2	,	,	PUNCT
admet-2043	572	3	needle	needle	NOUN
admet-2043	572	4	-	-	PUNCT
admet-2043	572	5	like	like	ADJ
admet-2043	572	6	or	or	CCONJ
admet-2043	572	7	fibre	fibre	NOUN
admet-2043	572	8	-	-	PUNCT
admet-2043	572	9	like	like	ADJ
admet-2043	572	10	nms	nms	NOUN
admet-2043	572	11	have	have	AUX
admet-2043	572	12	demonstrated	demonstrate	VERB
admet-2043	572	13	superior	superior	ADJ
admet-2043	572	14	penetration	penetration	NOUN
admet-2043	572	15	capabilities	capability	NOUN
admet-2043	572	16	attributed	attribute	VERB
admet-2043	572	17	to	to	ADP
admet-2043	572	18	their	their	PRON
admet-2043	572	19	shape	shape	NOUN
admet-2043	572	20	-	-	PUNCT
admet-2043	572	21	induced	induce	VERB
admet-2043	572	22	physical	physical	ADJ
admet-2043	572	23	disruption	disruption	NOUN
admet-2043	572	24	of	of	ADP
admet-2043	572	25	the	the	DET
admet-2043	572	26	bbb	bbb	NOUN
admet-2043	573	1	[	[	X
admet-2043	573	2	163	163	NUM
admet-2043	573	3	]	]	PUNCT
admet-2043	573	4	.	.	PUNCT
admet-2043	574	1	moreover	moreover	ADV
admet-2043	574	2	,	,	PUNCT
admet-2043	574	3	the	the	DET
admet-2043	574	4	shape	shape	NOUN
admet-2043	574	5	of	of	ADP
admet-2043	574	6	nms	nms	NOUN
admet-2043	574	7	influences	influence	VERB
admet-2043	574	8	cellular	cellular	ADJ
admet-2043	574	9	uptake	uptake	ADJ
admet-2043	574	10	mechanisms	mechanism	NOUN
admet-2043	574	11	,	,	PUNCT
admet-2043	574	12	as	as	SCONJ
admet-2043	574	13	elongated	elongate	VERB
admet-2043	574	14	structures	structure	NOUN
admet-2043	574	15	like	like	ADP
admet-2043	574	16	nanotubes	nanotube	NOUN
admet-2043	574	17	or	or	CCONJ
admet-2043	574	18	nanofibers	nanofiber	NOUN
admet-2043	574	19	can	can	AUX
admet-2043	574	20	be	be	AUX
admet-2043	574	21	internalized	internalize	VERB
admet-2043	574	22	through	through	ADP
admet-2043	574	23	endocytosis	endocytosis	NOUN
admet-2043	574	24	or	or	CCONJ
admet-2043	574	25	receptor	receptor	NOUN
admet-2043	574	26	-	-	PUNCT
admet-2043	574	27	mediated	mediate	VERB
admet-2043	574	28	pathways	pathway	NOUN
admet-2043	574	29	,	,	PUNCT
admet-2043	574	30	enhancing	enhance	VERB
admet-2043	574	31	their	their	PRON
admet-2043	574	32	transport	transport	NOUN
admet-2043	574	33	across	across	ADP
admet-2043	574	34	the	the	DET
admet-2043	574	35	bbb	bbb	PROPN
admet-2043	574	36	.	.	PUNCT
admet-2043	575	1	additionally	additionally	ADV
admet-2043	575	2	,	,	PUNCT
admet-2043	575	3	specific	specific	ADJ
admet-2043	575	4	nanomaterial	nanomaterial	ADJ
admet-2043	575	5	geometries	geometry	NOUN
admet-2043	575	6	,	,	PUNCT
admet-2043	575	7	such	such	ADJ
admet-2043	575	8	as	as	ADP
admet-2043	575	9	nanoneedles	nanoneedle	NOUN
admet-2043	575	10	or	or	CCONJ
admet-2043	575	11	nanowires	nanowire	NOUN
admet-2043	575	12	,	,	PUNCT
admet-2043	575	13	can	can	AUX
admet-2043	575	14	exert	exert	VERB
admet-2043	575	15	mechanical	mechanical	ADJ
admet-2043	575	16	forces	force	NOUN
admet-2043	575	17	on	on	ADP
admet-2043	575	18	tight	tight	ADJ
admet-2043	575	19	junctions	junction	NOUN
admet-2043	575	20	,	,	PUNCT
admet-2043	575	21	temporarily	temporarily	ADV
admet-2043	575	22	disrupting	disrupt	VERB
admet-2043	575	23	them	they	PRON
admet-2043	575	24	and	and	CCONJ
admet-2043	575	25	enabling	enable	VERB
admet-2043	575	26	nanomaterial	nanomaterial	ADJ
admet-2043	575	27	passage	passage	NOUN
admet-2043	575	28	.	.	PUNCT
admet-2043	576	1	it	it	PRON
admet-2043	576	2	is	be	AUX
admet-2043	576	3	also	also	ADV
admet-2043	576	4	important	important	ADJ
admet-2043	576	5	to	to	PART
admet-2043	576	6	consider	consider	VERB
admet-2043	576	7	stability	stability	NOUN
admet-2043	576	8	and	and	CCONJ
admet-2043	576	9	aggregation	aggregation	NOUN
admet-2043	576	10	since	since	SCONJ
admet-2043	576	11	nanomaterial	nanomaterial	ADJ
admet-2043	576	12	shape	shape	NOUN
admet-2043	576	13	affects	affect	VERB
admet-2043	576	14	their	their	PRON
admet-2043	576	15	propensity	propensity	NOUN
admet-2043	576	16	for	for	ADP
admet-2043	576	17	aggregation	aggregation	NOUN
admet-2043	576	18	,	,	PUNCT
admet-2043	576	19	potentially	potentially	ADV
admet-2043	576	20	hindering	hinder	VERB
admet-2043	576	21	bbb	bbb	PROPN
admet-2043	576	22	crossing	crossing	NOUN
admet-2043	576	23	[	[	X
admet-2043	576	24	164	164	NUM
admet-2043	576	25	]	]	PUNCT
admet-2043	576	26	.	.	PUNCT
admet-2043	577	1	ensuring	ensure	VERB
admet-2043	577	2	the	the	DET
admet-2043	577	3	stability	stability	NOUN
admet-2043	577	4	of	of	ADP
admet-2043	577	5	nanomaterials	nanomaterial	NOUN
admet-2043	577	6	under	under	ADP
admet-2043	577	7	physiological	physiological	ADJ
admet-2043	577	8	conditions	condition	NOUN
admet-2043	577	9	is	be	AUX
admet-2043	577	10	crucial	crucial	ADJ
admet-2043	577	11	for	for	ADP
admet-2043	577	12	maintaining	maintain	VERB
admet-2043	577	13	their	their	PRON
admet-2043	577	14	shape	shape	NOUN
admet-2043	577	15	-	-	PUNCT
admet-2043	577	16	related	relate	VERB
admet-2043	577	17	properties	property	NOUN
admet-2043	577	18	during	during	ADP
admet-2043	577	19	bbb	bbb	PROPN
admet-2043	577	20	transport	transport	NOUN
admet-2043	577	21	.	.	PUNCT
admet-2043	578	1	admet	admet	PROPN
admet-2043	578	2	&	&	CCONJ
admet-2043	578	3	dmpk	dmpk	PROPN
admet-2043	578	4	12(1	12(1	PROPN
admet-2043	578	5	)	)	PUNCT
admet-2043	578	6	(	(	PUNCT
admet-2043	578	7	2024	2024	NUM
admet-2043	578	8	)	)	PUNCT
admet-2043	578	9	63	63	NUM
admet-2043	578	10	-	-	SYM
admet-2043	578	11	105	105	NUM
admet-2043	578	12	nanomaterials	nanomaterial	NOUN
admet-2043	578	13	as	as	ADP
admet-2043	578	14	drug	drug	NOUN
admet-2043	578	15	delivery	delivery	NOUN
admet-2043	578	16	agents	agent	NOUN
admet-2043	578	17	for	for	ADP
admet-2043	578	18	overcoming	overcome	VERB
admet-2043	578	19	bbb	bbb	PROPN
admet-2043	578	20	doi	doi	NOUN
admet-2043	578	21	:	:	PUNCT
admet-2043	578	22	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	578	23	85	85	NUM
admet-2043	578	24	chemical	chemical	NOUN
admet-2043	578	25	composition	composition	NOUN
admet-2043	578	26	:	:	PUNCT
admet-2043	578	27	the	the	DET
admet-2043	578	28	chemical	chemical	NOUN
admet-2043	578	29	composition	composition	NOUN
admet-2043	578	30	of	of	ADP
admet-2043	578	31	nanomaterials	nanomaterial	NOUN
admet-2043	578	32	is	be	AUX
admet-2043	578	33	a	a	DET
admet-2043	578	34	critical	critical	ADJ
admet-2043	578	35	factor	factor	NOUN
admet-2043	578	36	in	in	ADP
admet-2043	578	37	determining	determine	VERB
admet-2043	578	38	their	their	PRON
admet-2043	578	39	properties	property	NOUN
admet-2043	578	40	and	and	CCONJ
admet-2043	578	41	potential	potential	ADJ
admet-2043	578	42	toxicity	toxicity	NOUN
admet-2043	578	43	when	when	SCONJ
admet-2043	578	44	used	use	VERB
admet-2043	578	45	for	for	ADP
admet-2043	578	46	drug	drug	NOUN
admet-2043	578	47	delivery	delivery	NOUN
admet-2043	578	48	across	across	ADP
admet-2043	578	49	the	the	DET
admet-2043	578	50	bbb	bbb	PROPN
admet-2043	578	51	.	.	PUNCT
admet-2043	579	1	liposomes	liposome	NOUN
admet-2043	579	2	,	,	PUNCT
admet-2043	579	3	composed	compose	VERB
admet-2043	579	4	of	of	ADP
admet-2043	579	5	lipid	lipid	ADJ
admet-2043	579	6	bilayers	bilayer	NOUN
admet-2043	579	7	and	and	CCONJ
admet-2043	579	8	polymeric	polymeric	ADJ
admet-2043	579	9	nms	nms	NOUN
admet-2043	579	10	made	make	VERB
admet-2043	579	11	of	of	ADP
admet-2043	579	12	biocompatible	biocompatible	ADJ
admet-2043	579	13	polymers	polymer	NOUN
admet-2043	579	14	,	,	PUNCT
admet-2043	579	15	are	be	AUX
admet-2043	579	16	commonly	commonly	ADV
admet-2043	579	17	utilized	utilize	VERB
admet-2043	579	18	for	for	ADP
admet-2043	579	19	their	their	PRON
admet-2043	579	20	versatility	versatility	NOUN
admet-2043	579	21	in	in	ADP
admet-2043	579	22	encapsulating	encapsulate	VERB
admet-2043	579	23	and	and	CCONJ
admet-2043	579	24	delivering	deliver	VERB
admet-2043	579	25	drugs	drug	NOUN
admet-2043	579	26	to	to	ADP
admet-2043	579	27	the	the	DET
admet-2043	579	28	bbb	bbb	NOUN
admet-2043	580	1	[	[	X
admet-2043	580	2	165	165	NUM
admet-2043	580	3	]	]	PUNCT
admet-2043	580	4	.	.	PUNCT
admet-2043	581	1	dendrimers	dendrimer	NOUN
admet-2043	581	2	,	,	PUNCT
admet-2043	581	3	highly	highly	ADV
admet-2043	581	4	branched	branched	ADJ
admet-2043	581	5	macromolecules	macromolecule	NOUN
admet-2043	581	6	,	,	PUNCT
admet-2043	581	7	offer	offer	VERB
admet-2043	581	8	tailored	tailor	VERB
admet-2043	581	9	surface	surface	NOUN
admet-2043	581	10	chemistry	chemistry	NOUN
admet-2043	581	11	for	for	ADP
admet-2043	581	12	improved	improved	ADJ
admet-2043	581	13	drug	drug	NOUN
admet-2043	581	14	stability	stability	NOUN
admet-2043	581	15	and	and	CCONJ
admet-2043	581	16	targeting	targeting	NOUN
admet-2043	581	17	,	,	PUNCT
admet-2043	581	18	but	but	CCONJ
admet-2043	581	19	their	their	PRON
admet-2043	581	20	potential	potential	ADJ
admet-2043	581	21	toxicity	toxicity	NOUN
admet-2043	581	22	requires	require	VERB
admet-2043	581	23	careful	careful	ADJ
admet-2043	581	24	consideration	consideration	NOUN
admet-2043	582	1	[	[	X
admet-2043	582	2	166	166	NUM
admet-2043	582	3	]	]	PUNCT
admet-2043	582	4	.	.	PUNCT
admet-2043	583	1	carbon	carbon	NOUN
admet-2043	583	2	-	-	PUNCT
admet-2043	583	3	based	base	VERB
admet-2043	583	4	nms	nms	NOUN
admet-2043	583	5	like	like	ADP
admet-2043	583	6	graphene	graphene	NOUN
admet-2043	583	7	and	and	CCONJ
admet-2043	583	8	carbon	carbon	NOUN
admet-2043	583	9	nanotubes	nanotube	NOUN
admet-2043	583	10	possess	possess	VERB
admet-2043	583	11	unique	unique	ADJ
admet-2043	583	12	properties	property	NOUN
admet-2043	583	13	that	that	PRON
admet-2043	583	14	make	make	VERB
admet-2043	583	15	them	they	PRON
admet-2043	583	16	attractive	attractive	ADJ
admet-2043	583	17	for	for	ADP
admet-2043	583	18	bbb	bbb	PROPN
admet-2043	583	19	drug	drug	NOUN
admet-2043	583	20	delivery	delivery	NOUN
admet-2043	583	21	,	,	PUNCT
admet-2043	583	22	but	but	CCONJ
admet-2043	583	23	thorough	thorough	ADJ
admet-2043	583	24	evaluation	evaluation	NOUN
admet-2043	583	25	is	be	AUX
admet-2043	583	26	necessary	necessary	ADJ
admet-2043	583	27	to	to	PART
admet-2043	583	28	ensure	ensure	VERB
admet-2043	583	29	their	their	PRON
admet-2043	583	30	safety	safety	NOUN
admet-2043	583	31	and	and	CCONJ
admet-2043	583	32	effectiveness	effectiveness	NOUN
admet-2043	583	33	[	[	X
admet-2043	583	34	167	167	NUM
admet-2043	583	35	]	]	PUNCT
admet-2043	583	36	.	.	PUNCT
admet-2043	584	1	cellular	cellular	ADJ
admet-2043	584	2	toxicity	toxicity	NOUN
admet-2043	584	3	:	:	PUNCT
admet-2043	584	4	ensuring	ensure	VERB
admet-2043	584	5	the	the	DET
admet-2043	584	6	safe	safe	ADJ
admet-2043	584	7	application	application	NOUN
admet-2043	584	8	of	of	ADP
admet-2043	584	9	nms	nms	PROPN
admet-2043	584	10	in	in	ADP
admet-2043	584	11	bbb	bbb	PROPN
admet-2043	584	12	drug	drug	NOUN
admet-2043	584	13	delivery	delivery	NOUN
admet-2043	584	14	requires	require	VERB
admet-2043	584	15	a	a	DET
admet-2043	584	16	thorough	thorough	ADJ
admet-2043	584	17	assessment	assessment	NOUN
admet-2043	584	18	of	of	ADP
admet-2043	584	19	their	their	PRON
admet-2043	584	20	potential	potential	ADJ
admet-2043	584	21	cellular	cellular	ADJ
admet-2043	584	22	toxicity	toxicity	NOUN
admet-2043	584	23	.	.	PUNCT
admet-2043	585	1	understanding	understand	VERB
admet-2043	585	2	how	how	SCONJ
admet-2043	585	3	nms	nms	PROPN
admet-2043	585	4	interact	interact	VERB
admet-2043	585	5	with	with	ADP
admet-2043	585	6	different	different	ADJ
admet-2043	585	7	brain	brain	NOUN
admet-2043	585	8	cell	cell	NOUN
admet-2043	585	9	types	type	NOUN
admet-2043	585	10	is	be	AUX
admet-2043	585	11	vital	vital	ADJ
admet-2043	585	12	for	for	ADP
admet-2043	585	13	developing	develop	VERB
admet-2043	585	14	effective	effective	ADJ
admet-2043	585	15	strategies	strategy	NOUN
admet-2043	585	16	that	that	PRON
admet-2043	585	17	minimize	minimize	VERB
admet-2043	585	18	adverse	adverse	ADJ
admet-2043	585	19	effects	effect	NOUN
admet-2043	585	20	[	[	X
admet-2043	585	21	105	105	NUM
admet-2043	585	22	]	]	PUNCT
admet-2043	585	23	.	.	PUNCT
admet-2043	586	1	by	by	ADP
admet-2043	586	2	comprehensively	comprehensively	ADV
admet-2043	586	3	evaluating	evaluate	VERB
admet-2043	586	4	the	the	DET
admet-2043	586	5	advantages	advantage	NOUN
admet-2043	586	6	and	and	CCONJ
admet-2043	586	7	risks	risk	NOUN
admet-2043	586	8	associated	associate	VERB
admet-2043	586	9	with	with	ADP
admet-2043	586	10	nms	nms	NOUN
admet-2043	586	11	-	-	PUNCT
admet-2043	586	12	induced	induce	VERB
admet-2043	586	13	cellular	cellular	ADJ
admet-2043	586	14	toxicity	toxicity	NOUN
admet-2043	586	15	,	,	PUNCT
admet-2043	586	16	researchers	researcher	NOUN
admet-2043	586	17	can	can	AUX
admet-2043	586	18	pave	pave	VERB
admet-2043	586	19	the	the	DET
admet-2043	586	20	way	way	NOUN
admet-2043	586	21	for	for	ADP
admet-2043	586	22	developing	develop	VERB
admet-2043	586	23	safer	safe	ADJ
admet-2043	586	24	and	and	CCONJ
admet-2043	586	25	more	more	ADV
admet-2043	586	26	efficient	efficient	ADJ
admet-2043	586	27	drug	drug	NOUN
admet-2043	586	28	delivery	delivery	NOUN
admet-2043	586	29	systems	system	NOUN
admet-2043	586	30	[	[	X
admet-2043	586	31	168	168	NUM
admet-2043	586	32	]	]	PUNCT
admet-2043	586	33	.	.	PUNCT
admet-2043	587	1	these	these	DET
admet-2043	587	2	systems	system	NOUN
admet-2043	587	3	have	have	VERB
admet-2043	587	4	the	the	DET
admet-2043	587	5	potential	potential	NOUN
admet-2043	587	6	to	to	PART
admet-2043	587	7	overcome	overcome	VERB
admet-2043	587	8	the	the	DET
admet-2043	587	9	bbb	bbb	PROPN
admet-2043	587	10	,	,	PUNCT
admet-2043	587	11	providing	provide	VERB
admet-2043	587	12	targeted	target	VERB
admet-2043	587	13	treatments	treatment	NOUN
admet-2043	587	14	for	for	ADP
admet-2043	587	15	various	various	ADJ
admet-2043	587	16	neurological	neurological	ADJ
admet-2043	587	17	disorders	disorder	NOUN
admet-2043	587	18	while	while	SCONJ
admet-2043	587	19	minimizing	minimize	VERB
admet-2043	587	20	harm	harm	NOUN
admet-2043	587	21	to	to	ADP
admet-2043	587	22	the	the	DET
admet-2043	587	23	cells	cell	NOUN
admet-2043	587	24	of	of	ADP
admet-2043	587	25	the	the	DET
admet-2043	587	26	brain	brain	NOUN
admet-2043	587	27	.	.	PUNCT
admet-2043	588	1	neurons	neuron	NOUN
admet-2043	588	2	:	:	PUNCT
admet-2043	588	3	assessing	assess	VERB
admet-2043	588	4	the	the	DET
admet-2043	588	5	potential	potential	ADJ
admet-2043	588	6	toxicity	toxicity	NOUN
admet-2043	588	7	of	of	ADP
admet-2043	588	8	nanomaterials	nanomaterial	NOUN
admet-2043	588	9	on	on	ADP
admet-2043	588	10	neurons	neuron	NOUN
admet-2043	588	11	is	be	AUX
admet-2043	588	12	of	of	ADP
admet-2043	588	13	utmost	utmost	ADJ
admet-2043	588	14	importance	importance	NOUN
admet-2043	588	15	to	to	PART
admet-2043	588	16	ensure	ensure	VERB
admet-2043	588	17	their	their	PRON
admet-2043	588	18	safe	safe	ADJ
admet-2043	588	19	application	application	NOUN
admet-2043	588	20	in	in	ADP
admet-2043	588	21	bbb	bbb	PROPN
admet-2043	588	22	drug	drug	NOUN
admet-2043	588	23	delivery	delivery	NOUN
admet-2043	588	24	.	.	PUNCT
admet-2043	589	1	by	by	ADP
admet-2043	589	2	understanding	understand	VERB
admet-2043	589	3	their	their	PRON
admet-2043	589	4	impact	impact	NOUN
admet-2043	589	5	on	on	ADP
admet-2043	589	6	neuronal	neuronal	ADJ
admet-2043	589	7	viability	viability	NOUN
admet-2043	589	8	,	,	PUNCT
admet-2043	589	9	morphology	morphology	NOUN
admet-2043	589	10	,	,	PUNCT
admet-2043	589	11	and	and	CCONJ
admet-2043	589	12	functionality	functionality	NOUN
admet-2043	589	13	,	,	PUNCT
admet-2043	589	14	researchers	researcher	NOUN
admet-2043	589	15	can	can	AUX
admet-2043	589	16	develop	develop	VERB
admet-2043	589	17	effective	effective	ADJ
admet-2043	589	18	strategies	strategy	NOUN
admet-2043	589	19	with	with	ADP
admet-2043	589	20	targeted	target	VERB
admet-2043	589	21	drug	drug	NOUN
admet-2043	589	22	delivery	delivery	NOUN
admet-2043	589	23	to	to	ADP
admet-2043	589	24	specific	specific	ADJ
admet-2043	589	25	neuronal	neuronal	ADJ
admet-2043	589	26	populations	population	NOUN
admet-2043	589	27	and	and	CCONJ
admet-2043	589	28	potential	potential	ADJ
admet-2043	589	29	neuroprotective	neuroprotective	ADJ
admet-2043	589	30	effects	effect	NOUN
admet-2043	589	31	[	[	X
admet-2043	589	32	169	169	NUM
admet-2043	589	33	]	]	PUNCT
admet-2043	589	34	.	.	PUNCT
admet-2043	590	1	in	in	ADP
admet-2043	590	2	a	a	DET
admet-2043	590	3	study	study	NOUN
admet-2043	590	4	investigating	investigate	VERB
admet-2043	590	5	the	the	DET
admet-2043	590	6	impact	impact	NOUN
admet-2043	590	7	of	of	ADP
admet-2043	590	8	metal	metal	NOUN
admet-2043	590	9	-	-	PUNCT
admet-2043	590	10	based	base	VERB
admet-2043	590	11	nms	nms	NOUN
admet-2043	590	12	on	on	ADP
admet-2043	590	13	neurons	neuron	NOUN
admet-2043	590	14	,	,	PUNCT
admet-2043	590	15	researchers	researcher	NOUN
admet-2043	590	16	exposed	expose	VERB
admet-2043	590	17	primary	primary	ADJ
admet-2043	590	18	neuronal	neuronal	ADJ
admet-2043	590	19	cultures	culture	NOUN
admet-2043	590	20	to	to	ADP
admet-2043	590	21	silver	silver	NOUN
admet-2043	590	22	nms	nms	PROPN
admet-2043	590	23	(	(	PUNCT
admet-2043	590	24	agnps	agnps	ADJ
admet-2043	590	25	)	)	PUNCT
admet-2043	590	26	and	and	CCONJ
admet-2043	590	27	gold	gold	NOUN
admet-2043	590	28	nms	nms	PROPN
admet-2043	590	29	(	(	PUNCT
admet-2043	590	30	aunps	aunps	PROPN
admet-2043	590	31	)	)	PUNCT
admet-2043	590	32	.	.	PUNCT
admet-2043	591	1	they	they	PRON
admet-2043	591	2	found	find	VERB
admet-2043	591	3	that	that	SCONJ
admet-2043	591	4	the	the	DET
admet-2043	591	5	nms	nms	NOUN
admet-2043	591	6	caused	cause	VERB
admet-2043	591	7	a	a	DET
admet-2043	591	8	dose	dose	NOUN
admet-2043	591	9	-	-	PUNCT
admet-2043	591	10	dependent	dependent	ADJ
admet-2043	591	11	decrease	decrease	NOUN
admet-2043	591	12	in	in	ADP
admet-2043	591	13	neuronal	neuronal	ADJ
admet-2043	591	14	viability	viability	NOUN
admet-2043	591	15	,	,	PUNCT
admet-2043	591	16	indicating	indicate	VERB
admet-2043	591	17	potential	potential	ADJ
admet-2043	591	18	toxicity	toxicity	NOUN
admet-2043	591	19	.	.	PUNCT
admet-2043	592	1	additionally	additionally	ADV
admet-2043	592	2	,	,	PUNCT
admet-2043	592	3	the	the	DET
admet-2043	592	4	nms	nms	NOUN
admet-2043	592	5	disrupted	disrupt	VERB
admet-2043	592	6	neuronal	neuronal	ADJ
admet-2043	592	7	processes	process	NOUN
admet-2043	592	8	and	and	CCONJ
admet-2043	592	9	impaired	impaired	ADJ
admet-2043	592	10	synaptic	synaptic	ADJ
admet-2043	592	11	activity	activity	NOUN
admet-2043	592	12	,	,	PUNCT
admet-2043	592	13	as	as	SCONJ
admet-2043	592	14	evidenced	evidence	VERB
admet-2043	592	15	by	by	ADP
admet-2043	592	16	altered	altered	ADJ
admet-2043	592	17	calcium	calcium	NOUN
admet-2043	592	18	influx	influx	NOUN
admet-2043	592	19	and	and	CCONJ
admet-2043	592	20	reduced	reduce	VERB
admet-2043	592	21	expression	expression	NOUN
admet-2043	592	22	of	of	ADP
admet-2043	592	23	synaptic	synaptic	ADJ
admet-2043	592	24	proteins	protein	NOUN
admet-2043	592	25	[	[	X
admet-2043	592	26	170	170	NUM
admet-2043	592	27	]	]	PUNCT
admet-2043	592	28	.	.	PUNCT
admet-2043	593	1	astrocytes	astrocyte	NOUN
admet-2043	593	2	:	:	PUNCT
admet-2043	593	3	astrocytes	astrocyte	NOUN
admet-2043	593	4	play	play	VERB
admet-2043	593	5	a	a	DET
admet-2043	593	6	crucial	crucial	ADJ
admet-2043	593	7	role	role	NOUN
admet-2043	593	8	in	in	ADP
admet-2043	593	9	maintaining	maintain	VERB
admet-2043	593	10	brain	brain	NOUN
admet-2043	593	11	homeostasis	homeostasis	NOUN
admet-2043	593	12	and	and	CCONJ
admet-2043	593	13	supporting	support	VERB
admet-2043	593	14	neuronal	neuronal	ADJ
admet-2043	593	15	function	function	NOUN
admet-2043	593	16	[	[	X
admet-2043	593	17	171	171	NUM
admet-2043	593	18	]	]	PUNCT
admet-2043	593	19	.	.	PUNCT
admet-2043	594	1	nms	nms	PROPN
admet-2043	594	2	can	can	AUX
admet-2043	594	3	influence	influence	VERB
admet-2043	594	4	astrocyte	astrocyte	NOUN
admet-2043	594	5	viability	viability	NOUN
admet-2043	594	6	,	,	PUNCT
admet-2043	594	7	activation	activation	NOUN
admet-2043	594	8	,	,	PUNCT
admet-2043	594	9	and	and	CCONJ
admet-2043	594	10	the	the	DET
admet-2043	594	11	release	release	NOUN
admet-2043	594	12	of	of	ADP
admet-2043	594	13	inflammatory	inflammatory	ADJ
admet-2043	594	14	mediators	mediator	NOUN
admet-2043	594	15	.	.	PUNCT
admet-2043	595	1	in	in	ADP
admet-2043	595	2	a	a	DET
admet-2043	595	3	study	study	NOUN
admet-2043	595	4	examining	examine	VERB
admet-2043	595	5	the	the	DET
admet-2043	595	6	effects	effect	NOUN
admet-2043	595	7	of	of	ADP
admet-2043	595	8	carbon	carbon	NOUN
admet-2043	595	9	nanotubes	nanotube	NOUN
admet-2043	595	10	(	(	PUNCT
admet-2043	595	11	cnts	cnt	NOUN
admet-2043	595	12	)	)	PUNCT
admet-2043	595	13	on	on	ADP
admet-2043	595	14	astrocytes	astrocyte	NOUN
admet-2043	595	15	,	,	PUNCT
admet-2043	595	16	researchers	researcher	NOUN
admet-2043	595	17	exposed	expose	VERB
admet-2043	595	18	cultured	cultured	ADJ
admet-2043	595	19	astrocytes	astrocyte	NOUN
admet-2043	595	20	to	to	ADP
admet-2043	595	21	different	different	ADJ
admet-2043	595	22	concentrations	concentration	NOUN
admet-2043	595	23	of	of	ADP
admet-2043	595	24	cnts	cnts	PROPN
admet-2043	595	25	.	.	PUNCT
admet-2043	596	1	they	they	PRON
admet-2043	596	2	observed	observe	VERB
admet-2043	596	3	that	that	SCONJ
admet-2043	596	4	cnt	cnt	PROPN
admet-2043	596	5	exposure	exposure	NOUN
admet-2043	596	6	led	lead	VERB
admet-2043	596	7	to	to	ADP
admet-2043	596	8	a	a	DET
admet-2043	596	9	dose	dose	NOUN
admet-2043	596	10	-	-	PUNCT
admet-2043	596	11	dependent	dependent	ADJ
admet-2043	596	12	decrease	decrease	NOUN
admet-2043	596	13	in	in	ADP
admet-2043	596	14	astrocyte	astrocyte	NOUN
admet-2043	596	15	viability	viability	NOUN
admet-2043	596	16	,	,	PUNCT
admet-2043	596	17	indicating	indicate	VERB
admet-2043	596	18	potential	potential	ADJ
admet-2043	596	19	toxicity	toxicity	NOUN
admet-2043	596	20	.	.	PUNCT
admet-2043	597	1	additionally	additionally	ADV
admet-2043	597	2	,	,	PUNCT
admet-2043	597	3	the	the	DET
admet-2043	597	4	cnts	cnt	NOUN
admet-2043	597	5	triggered	trigger	VERB
admet-2043	597	6	the	the	DET
admet-2043	597	7	activation	activation	NOUN
admet-2043	597	8	of	of	ADP
admet-2043	597	9	astrocytes	astrocyte	NOUN
admet-2043	597	10	,	,	PUNCT
admet-2043	597	11	as	as	SCONJ
admet-2043	597	12	evidenced	evidence	VERB
admet-2043	597	13	by	by	ADP
admet-2043	597	14	an	an	DET
admet-2043	597	15	increase	increase	NOUN
admet-2043	597	16	in	in	ADP
admet-2043	597	17	the	the	DET
admet-2043	597	18	expression	expression	NOUN
admet-2043	597	19	of	of	ADP
admet-2043	597	20	activation	activation	NOUN
admet-2043	597	21	markers	marker	NOUN
admet-2043	597	22	such	such	ADJ
admet-2043	597	23	as	as	ADP
admet-2043	597	24	gfap	gfap	ADJ
admet-2043	597	25	(	(	PUNCT
admet-2043	597	26	glial	glial	ADJ
admet-2043	597	27	fibrillary	fibrillary	ADJ
admet-2043	597	28	acidic	acidic	ADJ
admet-2043	597	29	protein	protein	NOUN
admet-2043	597	30	)	)	PUNCT
admet-2043	597	31	.	.	PUNCT
admet-2043	598	1	furthermore	furthermore	ADV
admet-2043	598	2	,	,	PUNCT
admet-2043	598	3	interleukin-6	interleukin-6	PROPN
admet-2043	598	4	(	(	PUNCT
admet-2043	598	5	il-6	il-6	NUM
admet-2043	598	6	)	)	PUNCT
admet-2043	598	7	and	and	CCONJ
admet-2043	598	8	tumour	tumour	NOUN
admet-2043	598	9	necrosis	necrosis	NOUN
admet-2043	598	10	factor	factor	NOUN
admet-2043	598	11	-	-	PUNCT
admet-2043	598	12	alpha	alpha	NOUN
admet-2043	598	13	(	(	PUNCT
admet-2043	598	14	tnf-	tnf-	INTJ
admet-2043	598	15	)	)	PUNCT
admet-2043	598	16	were	be	AUX
admet-2043	598	17	released	release	VERB
admet-2043	598	18	as	as	ADP
admet-2043	598	19	a	a	DET
admet-2043	598	20	result	result	NOUN
admet-2043	598	21	of	of	ADP
admet-2043	598	22	the	the	DET
admet-2043	598	23	exposure	exposure	NOUN
admet-2043	598	24	to	to	ADP
admet-2043	598	25	cnts	cnts	PROPN
admet-2043	598	26	,	,	PUNCT
admet-2043	598	27	indicating	indicate	VERB
admet-2043	598	28	an	an	DET
admet-2043	598	29	inflammatory	inflammatory	ADJ
admet-2043	598	30	reaction	reaction	NOUN
admet-2043	598	31	.	.	PUNCT
admet-2043	599	1	this	this	DET
admet-2043	599	2	study	study	NOUN
admet-2043	599	3	underscores	underscore	VERB
admet-2043	599	4	the	the	DET
admet-2043	599	5	importance	importance	NOUN
admet-2043	599	6	of	of	ADP
admet-2043	599	7	evaluating	evaluate	VERB
admet-2043	599	8	the	the	DET
admet-2043	599	9	impact	impact	NOUN
admet-2043	599	10	of	of	ADP
admet-2043	599	11	nms	nms	NOUN
admet-2043	599	12	on	on	ADP
admet-2043	599	13	astrocytes	astrocyte	NOUN
admet-2043	599	14	and	and	CCONJ
admet-2043	599	15	their	their	PRON
admet-2043	599	16	potential	potential	ADJ
admet-2043	599	17	role	role	NOUN
admet-2043	599	18	in	in	ADP
admet-2043	599	19	neuroinflammation	neuroinflammation	NOUN
admet-2043	599	20	,	,	PUNCT
admet-2043	599	21	which	which	PRON
admet-2043	599	22	can	can	AUX
admet-2043	599	23	have	have	VERB
admet-2043	599	24	implications	implication	NOUN
admet-2043	599	25	for	for	ADP
admet-2043	599	26	bbb	bbb	PROPN
admet-2043	599	27	in	in	ADP
admet-2043	599	28	drug	drug	NOUN
admet-2043	599	29	delivery	delivery	NOUN
admet-2043	599	30	strategies	strategy	NOUN
admet-2043	599	31	[	[	X
admet-2043	599	32	172	172	NUM
admet-2043	599	33	]	]	PUNCT
admet-2043	599	34	.	.	PUNCT
admet-2043	600	1	microglia	microglia	ADJ
admet-2043	600	2	:	:	PUNCT
admet-2043	600	3	inflammation	inflammation	NOUN
admet-2043	600	4	and	and	CCONJ
admet-2043	600	5	immunological	immunological	ADJ
admet-2043	600	6	responses	response	NOUN
admet-2043	600	7	are	be	AUX
admet-2043	600	8	greatly	greatly	ADV
admet-2043	600	9	influenced	influence	VERB
admet-2043	600	10	by	by	ADP
admet-2043	600	11	microglia	microglia	NOUN
admet-2043	600	12	,	,	PUNCT
admet-2043	600	13	the	the	DET
admet-2043	600	14	central	central	ADJ
admet-2043	600	15	nervous	nervous	ADJ
admet-2043	600	16	system	system	NOUN
admet-2043	600	17	's	's	PART
admet-2043	600	18	resident	resident	ADJ
admet-2043	600	19	immune	immune	ADJ
admet-2043	600	20	cells	cell	NOUN
admet-2043	600	21	.	.	PUNCT
admet-2043	601	1	the	the	DET
admet-2043	601	2	production	production	NOUN
admet-2043	601	3	of	of	ADP
admet-2043	601	4	reactive	reactive	ADJ
admet-2043	601	5	species	specie	NOUN
admet-2043	601	6	,	,	PUNCT
admet-2043	601	7	pro	pro	ADJ
admet-2043	601	8	-	-	ADJ
admet-2043	601	9	inflammatory	inflammatory	ADJ
admet-2043	601	10	cytokines	cytokine	NOUN
admet-2043	601	11	,	,	PUNCT
admet-2043	601	12	and	and	CCONJ
admet-2043	601	13	an	an	DET
admet-2043	601	14	inflammatory	inflammatory	ADJ
admet-2043	601	15	response	response	NOUN
admet-2043	601	16	can	can	AUX
admet-2043	601	17	all	all	PRON
admet-2043	601	18	be	be	AUX
admet-2043	601	19	caused	cause	VERB
admet-2043	601	20	by	by	ADP
admet-2043	601	21	nms	nms	NOUN
admet-2043	601	22	activating	activate	VERB
admet-2043	601	23	microglia	microglia	NOUN
admet-2043	601	24	.	.	PUNCT
admet-2043	602	1	evaluating	evaluate	VERB
admet-2043	602	2	microglial	microglial	ADJ
admet-2043	602	3	activation	activation	NOUN
admet-2043	602	4	,	,	PUNCT
admet-2043	602	5	cytokine	cytokine	NOUN
admet-2043	602	6	release	release	NOUN
admet-2043	602	7	,	,	PUNCT
admet-2043	602	8	and	and	CCONJ
admet-2043	602	9	oxidative	oxidative	ADJ
admet-2043	602	10	stress	stress	NOUN
admet-2043	602	11	markers	marker	NOUN
admet-2043	602	12	provides	provide	VERB
admet-2043	602	13	insights	insight	NOUN
admet-2043	602	14	into	into	ADP
admet-2043	602	15	the	the	DET
admet-2043	602	16	potential	potential	ADJ
admet-2043	602	17	toxicity	toxicity	NOUN
admet-2043	602	18	of	of	ADP
admet-2043	602	19	nanomaterials	nanomaterial	NOUN
admet-2043	602	20	on	on	ADP
admet-2043	602	21	microglia	microglia	NOUN
admet-2043	602	22	[	[	X
admet-2043	602	23	173	173	NUM
admet-2043	602	24	]	]	PUNCT
admet-2043	602	25	.	.	PUNCT
admet-2043	603	1	in	in	ADP
admet-2043	603	2	order	order	NOUN
admet-2043	603	3	to	to	PART
admet-2043	603	4	examine	examine	VERB
admet-2043	603	5	how	how	SCONJ
admet-2043	603	6	silver	silver	ADJ
admet-2043	603	7	nms	nms	NOUN
admet-2043	603	8	(	(	PUNCT
admet-2043	603	9	agnps	agnps	ADJ
admet-2043	603	10	)	)	PUNCT
admet-2043	603	11	affect	affect	VERB
admet-2043	603	12	microglia	microglia	NOUN
admet-2043	603	13	,	,	PUNCT
admet-2043	603	14	researchers	researcher	NOUN
admet-2043	603	15	subjected	subject	VERB
admet-2043	603	16	cultured	cultured	ADJ
admet-2043	603	17	microglial	microglial	ADJ
admet-2043	603	18	cells	cell	NOUN
admet-2043	603	19	to	to	ADP
admet-2043	603	20	various	various	ADJ
admet-2043	603	21	agnp	agnp	NOUN
admet-2043	603	22	concentrations	concentration	NOUN
admet-2043	603	23	.	.	PUNCT
admet-2043	604	1	agnps	agnps	PROPN
admet-2043	604	2	induced	induce	VERB
admet-2043	604	3	oxidative	oxidative	ADJ
admet-2043	604	4	stress	stress	NOUN
admet-2043	604	5	in	in	ADP
admet-2043	604	6	microglia	microglia	NOUN
admet-2043	604	7	,	,	PUNCT
admet-2043	604	8	as	as	SCONJ
admet-2043	604	9	indicated	indicate	VERB
admet-2043	604	10	by	by	ADP
admet-2043	604	11	elevated	elevated	ADJ
admet-2043	604	12	levels	level	NOUN
admet-2043	604	13	of	of	ADP
admet-2043	604	14	reactive	reactive	ADJ
admet-2043	604	15	oxygen	oxygen	NOUN
admet-2043	604	16	species	specie	NOUN
admet-2043	604	17	(	(	PUNCT
admet-2043	604	18	ros	ros	PROPN
admet-2043	604	19	)	)	PUNCT
admet-2043	604	20	.	.	PUNCT
admet-2043	605	1	these	these	DET
admet-2043	605	2	findings	finding	NOUN
admet-2043	605	3	highlight	highlight	VERB
admet-2043	605	4	the	the	DET
admet-2043	605	5	potential	potential	NOUN
admet-2043	605	6	for	for	ADP
admet-2043	605	7	nanomaterial	nanomaterial	NOUN
admet-2043	605	8	-	-	PUNCT
admet-2043	605	9	induced	induce	VERB
admet-2043	605	10	inflammatory	inflammatory	ADJ
admet-2043	605	11	responses	response	NOUN
admet-2043	605	12	and	and	CCONJ
admet-2043	605	13	oxidative	oxidative	ADJ
admet-2043	605	14	stress	stress	NOUN
admet-2043	605	15	in	in	ADP
admet-2043	605	16	microglia	microglia	NOUN
admet-2043	605	17	,	,	PUNCT
admet-2043	605	18	underscoring	underscore	VERB
admet-2043	605	19	the	the	DET
admet-2043	605	20	importance	importance	NOUN
admet-2043	605	21	of	of	ADP
admet-2043	605	22	assessing	assess	VERB
admet-2043	605	23	the	the	DET
admet-2043	605	24	potential	potential	ADJ
admet-2043	605	25	toxicity	toxicity	NOUN
admet-2043	605	26	of	of	ADP
admet-2043	605	27	nanomaterials	nanomaterial	NOUN
admet-2043	605	28	on	on	ADP
admet-2043	605	29	microglia	microglia	NOUN
admet-2043	605	30	in	in	ADP
admet-2043	605	31	the	the	DET
admet-2043	605	32	context	context	NOUN
admet-2043	605	33	of	of	ADP
admet-2043	605	34	blood	blood	NOUN
admet-2043	605	35	-	-	PUNCT
admet-2043	605	36	brain	brain	NOUN
admet-2043	605	37	barrier	barrier	NOUN
admet-2043	605	38	drug	drug	NOUN
admet-2043	605	39	delivery	delivery	NOUN
admet-2043	605	40	[	[	X
admet-2043	605	41	174	174	NUM
admet-2043	605	42	]	]	PUNCT
admet-2043	605	43	.	.	PUNCT
admet-2043	606	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	606	2	m.	m.	NOUN
admet-2043	606	3	kulkarni	kulkarni	PROPN
admet-2043	606	4	et	et	PROPN
admet-2043	606	5	al	al	PROPN
admet-2043	606	6	.	.	PROPN
admet-2043	606	7	admet	admet	PROPN
admet-2043	606	8	&	&	CCONJ
admet-2043	606	9	dmpk	dmpk	PROPN
admet-2043	606	10	12(1	12(1	PROPN
admet-2043	606	11	)	)	PUNCT
admet-2043	606	12	(	(	PUNCT
admet-2043	606	13	2024	2024	NUM
admet-2043	606	14	)	)	PUNCT
admet-2043	606	15	63	63	NUM
admet-2043	606	16	-	-	SYM
admet-2043	606	17	105	105	NUM
admet-2043	606	18	86	86	NUM
admet-2043	606	19	endothelial	endothelial	ADJ
admet-2043	606	20	cells	cell	NOUN
admet-2043	606	21	(	(	PUNCT
admet-2043	606	22	ecs	ecs	PROPN
admet-2043	606	23	):	):	PUNCT
admet-2043	606	24	bbb	bbb	PROPN
admet-2043	606	25	endothelial	endothelial	ADJ
admet-2043	606	26	cells	cell	NOUN
admet-2043	606	27	form	form	VERB
admet-2043	606	28	a	a	DET
admet-2043	606	29	crucial	crucial	ADJ
admet-2043	606	30	barrier	barrier	NOUN
admet-2043	606	31	and	and	CCONJ
admet-2043	606	32	regulate	regulate	VERB
admet-2043	606	33	the	the	DET
admet-2043	606	34	transport	transport	NOUN
admet-2043	606	35	of	of	ADP
admet-2043	606	36	molecules	molecule	NOUN
admet-2043	606	37	into	into	ADP
admet-2043	606	38	the	the	DET
admet-2043	606	39	brain	brain	NOUN
admet-2043	606	40	.	.	PUNCT
admet-2043	607	1	nms	nms	NOUN
admet-2043	607	2	can	can	AUX
admet-2043	607	3	interact	interact	VERB
admet-2043	607	4	with	with	ADP
admet-2043	607	5	bbb	bbb	PROPN
admet-2043	607	6	endothelial	endothelial	ADJ
admet-2043	607	7	cells	cell	NOUN
admet-2043	607	8	,	,	PUNCT
admet-2043	607	9	affecting	affect	VERB
admet-2043	607	10	their	their	PRON
admet-2043	607	11	viability	viability	NOUN
admet-2043	607	12	,	,	PUNCT
admet-2043	607	13	integrity	integrity	NOUN
admet-2043	607	14	,	,	PUNCT
admet-2043	607	15	and	and	CCONJ
admet-2043	607	16	tight	tight	ADJ
admet-2043	607	17	junction	junction	NOUN
admet-2043	607	18	proteins	protein	NOUN
admet-2043	607	19	[	[	X
admet-2043	607	20	142	142	NUM
admet-2043	607	21	]	]	PUNCT
admet-2043	607	22	.	.	PUNCT
admet-2043	608	1	disruption	disruption	NOUN
admet-2043	608	2	of	of	ADP
admet-2043	608	3	tight	tight	ADJ
admet-2043	608	4	junctions	junction	NOUN
admet-2043	608	5	can	can	AUX
admet-2043	608	6	compromise	compromise	VERB
admet-2043	608	7	the	the	DET
admet-2043	608	8	integrity	integrity	NOUN
admet-2043	608	9	of	of	ADP
admet-2043	608	10	the	the	DET
admet-2043	608	11	bbb	bbb	PROPN
admet-2043	608	12	.	.	PUNCT
admet-2043	609	1	evaluating	evaluate	VERB
admet-2043	609	2	ec	ec	PROPN
admet-2043	609	3	viability	viability	NOUN
admet-2043	609	4	,	,	PUNCT
admet-2043	609	5	barrier	barrier	NOUN
admet-2043	609	6	integrity	integrity	NOUN
admet-2043	609	7	,	,	PUNCT
admet-2043	609	8	tight	tight	ADJ
admet-2043	609	9	junction	junction	NOUN
admet-2043	609	10	proteins	protein	NOUN
admet-2043	609	11	,	,	PUNCT
admet-2043	609	12	and	and	CCONJ
admet-2043	609	13	inflammatory	inflammatory	ADJ
admet-2043	609	14	responses	response	NOUN
admet-2043	609	15	is	be	AUX
admet-2043	609	16	important	important	ADJ
admet-2043	609	17	in	in	ADP
admet-2043	609	18	assessing	assess	VERB
admet-2043	609	19	the	the	DET
admet-2043	609	20	potential	potential	ADJ
admet-2043	609	21	toxicity	toxicity	NOUN
admet-2043	609	22	of	of	ADP
admet-2043	609	23	nms	nms	NOUN
admet-2043	609	24	on	on	ADP
admet-2043	609	25	bbb	bbb	PROPN
admet-2043	609	26	endothelial	endothelial	ADJ
admet-2043	609	27	cells	cell	NOUN
admet-2043	609	28	.	.	PUNCT
admet-2043	610	1	in	in	ADP
admet-2043	610	2	a	a	DET
admet-2043	610	3	study	study	NOUN
admet-2043	610	4	investigating	investigate	VERB
admet-2043	610	5	the	the	DET
admet-2043	610	6	effects	effect	NOUN
admet-2043	610	7	of	of	ADP
admet-2043	610	8	liposomes	liposome	NOUN
admet-2043	610	9	on	on	ADP
admet-2043	610	10	bbb	bbb	PROPN
admet-2043	610	11	endothelial	endothelial	ADJ
admet-2043	610	12	cells	cell	NOUN
admet-2043	610	13	,	,	PUNCT
admet-2043	610	14	researchers	researcher	NOUN
admet-2043	610	15	exposed	expose	VERB
admet-2043	610	16	cultured	cultured	ADJ
admet-2043	610	17	endothelial	endothelial	ADJ
admet-2043	610	18	cells	cell	NOUN
admet-2043	610	19	to	to	ADP
admet-2043	610	20	liposomes	liposome	NOUN
admet-2043	610	21	of	of	ADP
admet-2043	610	22	different	different	ADJ
admet-2043	610	23	compositions	composition	NOUN
admet-2043	610	24	.	.	PUNCT
admet-2043	611	1	they	they	PRON
admet-2043	611	2	found	find	VERB
admet-2043	611	3	that	that	DET
admet-2043	611	4	exposure	exposure	NOUN
admet-2043	611	5	to	to	ADP
admet-2043	611	6	liposomes	liposome	NOUN
admet-2043	611	7	led	lead	VERB
admet-2043	611	8	to	to	ADP
admet-2043	611	9	changes	change	NOUN
admet-2043	611	10	in	in	ADP
admet-2043	611	11	endothelial	endothelial	ADJ
admet-2043	611	12	cell	cell	NOUN
admet-2043	611	13	viability	viability	NOUN
admet-2043	611	14	and	and	CCONJ
admet-2043	611	15	morphology	morphology	NOUN
admet-2043	611	16	,	,	PUNCT
admet-2043	611	17	suggesting	suggest	VERB
admet-2043	611	18	potential	potential	ADJ
admet-2043	611	19	toxicity	toxicity	NOUN
admet-2043	611	20	.	.	PUNCT
admet-2043	612	1	additionally	additionally	ADV
admet-2043	612	2	,	,	PUNCT
admet-2043	612	3	the	the	DET
admet-2043	612	4	liposomes	liposome	NOUN
admet-2043	612	5	affected	affect	VERB
admet-2043	612	6	the	the	DET
admet-2043	612	7	integrity	integrity	NOUN
admet-2043	612	8	of	of	ADP
admet-2043	612	9	the	the	DET
admet-2043	612	10	tight	tight	ADJ
admet-2043	612	11	junction	junction	NOUN
admet-2043	612	12	proteins	protein	NOUN
admet-2043	612	13	that	that	PRON
admet-2043	612	14	regulate	regulate	VERB
admet-2043	612	15	the	the	DET
admet-2043	612	16	permeability	permeability	NOUN
admet-2043	612	17	of	of	ADP
admet-2043	612	18	the	the	DET
admet-2043	612	19	bbb	bbb	PROPN
admet-2043	612	20	,	,	PUNCT
admet-2043	612	21	indicating	indicate	VERB
admet-2043	612	22	potential	potential	ADJ
admet-2043	612	23	disruption	disruption	NOUN
admet-2043	612	24	of	of	ADP
admet-2043	612	25	the	the	DET
admet-2043	612	26	barrier	barrier	NOUN
admet-2043	612	27	function	function	NOUN
admet-2043	612	28	[	[	X
admet-2043	612	29	142	142	NUM
admet-2043	612	30	]	]	PUNCT
admet-2043	612	31	.	.	PUNCT
admet-2043	613	1	systemic	systemic	ADJ
admet-2043	613	2	toxicity	toxicity	NOUN
admet-2043	613	3	:	:	PUNCT
admet-2043	613	4	to	to	ADP
admet-2043	613	5	date	date	NOUN
admet-2043	613	6	,	,	PUNCT
admet-2043	613	7	systemic	systemic	ADJ
admet-2043	613	8	toxicity	toxicity	NOUN
admet-2043	613	9	has	have	AUX
admet-2043	613	10	been	be	AUX
admet-2043	613	11	a	a	DET
admet-2043	613	12	significant	significant	ADJ
admet-2043	613	13	challenge	challenge	NOUN
admet-2043	613	14	in	in	ADP
admet-2043	613	15	the	the	DET
admet-2043	613	16	field	field	NOUN
admet-2043	613	17	of	of	ADP
admet-2043	613	18	drug	drug	NOUN
admet-2043	613	19	delivery	delivery	NOUN
admet-2043	613	20	to	to	ADP
admet-2043	613	21	the	the	DET
admet-2043	613	22	brain	brain	NOUN
admet-2043	613	23	,	,	PUNCT
admet-2043	613	24	with	with	ADP
admet-2043	613	25	systemic	systemic	ADJ
admet-2043	613	26	administration	administration	NOUN
admet-2043	613	27	being	be	AUX
admet-2043	613	28	the	the	DET
admet-2043	613	29	most	most	ADV
admet-2043	613	30	extensively	extensively	ADV
admet-2043	613	31	studied	study	VERB
admet-2043	613	32	approach	approach	NOUN
admet-2043	613	33	.	.	PUNCT
admet-2043	614	1	to	to	PART
admet-2043	614	2	overcome	overcome	VERB
admet-2043	614	3	this	this	DET
admet-2043	614	4	obstacle	obstacle	NOUN
admet-2043	614	5	,	,	PUNCT
admet-2043	614	6	it	it	PRON
admet-2043	614	7	is	be	AUX
admet-2043	614	8	crucial	crucial	ADJ
admet-2043	614	9	to	to	PART
admet-2043	614	10	develop	develop	VERB
admet-2043	614	11	a	a	DET
admet-2043	614	12	design	design	NOUN
admet-2043	614	13	where	where	SCONJ
admet-2043	614	14	the	the	DET
admet-2043	614	15	active	active	ADJ
admet-2043	614	16	drug	drug	NOUN
admet-2043	614	17	can	can	AUX
admet-2043	614	18	be	be	AUX
admet-2043	614	19	encapsulated	encapsulate	VERB
admet-2043	614	20	within	within	ADP
admet-2043	614	21	non	non	ADJ
admet-2043	614	22	-	-	ADJ
admet-2043	614	23	toxic	toxic	ADJ
admet-2043	614	24	nms	nms	NOUN
admet-2043	614	25	and	and	CCONJ
admet-2043	614	26	capable	capable	ADJ
admet-2043	614	27	of	of	ADP
admet-2043	614	28	crossing	cross	VERB
admet-2043	614	29	the	the	DET
admet-2043	614	30	bbb	bbb	NOUN
admet-2043	615	1	[	[	X
admet-2043	615	2	13	13	NUM
admet-2043	615	3	]	]	PUNCT
admet-2043	615	4	.	.	PUNCT
admet-2043	616	1	additionally	additionally	ADV
admet-2043	616	2	,	,	PUNCT
admet-2043	616	3	various	various	ADJ
admet-2043	616	4	approaches	approach	NOUN
admet-2043	616	5	have	have	AUX
admet-2043	616	6	been	be	AUX
admet-2043	616	7	developed	develop	VERB
admet-2043	616	8	to	to	PART
admet-2043	616	9	enhance	enhance	VERB
admet-2043	616	10	bbb	bbb	PROPN
admet-2043	616	11	permeability	permeability	NOUN
admet-2043	616	12	,	,	PUNCT
admet-2043	616	13	such	such	ADJ
admet-2043	616	14	as	as	ADP
admet-2043	616	15	the	the	DET
admet-2043	616	16	injection	injection	NOUN
admet-2043	616	17	of	of	ADP
admet-2043	616	18	hyperosmolar	hyperosmolar	ADJ
admet-2043	616	19	mannitol	mannitol	NOUN
admet-2043	616	20	to	to	PART
admet-2043	616	21	induce	induce	VERB
admet-2043	616	22	reversible	reversible	ADJ
admet-2043	616	23	disruption	disruption	NOUN
admet-2043	616	24	[	[	X
admet-2043	616	25	32	32	NUM
admet-2043	616	26	]	]	PUNCT
admet-2043	616	27	or	or	CCONJ
admet-2043	616	28	the	the	DET
admet-2043	616	29	application	application	NOUN
admet-2043	616	30	of	of	ADP
admet-2043	616	31	ultrasound	ultrasound	NOUN
admet-2043	616	32	as	as	ADP
admet-2043	616	33	a	a	DET
admet-2043	616	34	physical	physical	ADJ
admet-2043	616	35	stimulus	stimulus	NOUN
admet-2043	616	36	[	[	X
admet-2043	616	37	12,175	12,175	NUM
admet-2043	616	38	]	]	PUNCT
admet-2043	616	39	.	.	PUNCT
admet-2043	617	1	however	however	ADV
admet-2043	617	2	,	,	PUNCT
admet-2043	617	3	bbb	bbb	ADJ
admet-2043	617	4	disruption	disruption	NOUN
admet-2043	617	5	can	can	AUX
admet-2043	617	6	result	result	VERB
admet-2043	617	7	in	in	ADP
admet-2043	617	8	the	the	DET
admet-2043	617	9	influx	influx	NOUN
admet-2043	617	10	of	of	ADP
admet-2043	617	11	neurotoxic	neurotoxic	ADJ
admet-2043	617	12	substances	substance	NOUN
admet-2043	617	13	,	,	PUNCT
admet-2043	617	14	leading	lead	VERB
admet-2043	617	15	to	to	ADP
admet-2043	617	16	substantial	substantial	ADJ
admet-2043	617	17	brain	brain	NOUN
admet-2043	617	18	damage	damage	NOUN
admet-2043	617	19	[	[	X
admet-2043	617	20	13	13	NUM
admet-2043	617	21	]	]	PUNCT
admet-2043	617	22	.	.	PUNCT
admet-2043	618	1	thus	thus	ADV
admet-2043	618	2	,	,	PUNCT
admet-2043	618	3	in	in	ADP
admet-2043	618	4	order	order	NOUN
admet-2043	618	5	to	to	PART
admet-2043	618	6	treat	treat	VERB
admet-2043	618	7	neurological	neurological	ADJ
admet-2043	618	8	diseases	disease	NOUN
admet-2043	618	9	while	while	SCONJ
admet-2043	618	10	avoiding	avoid	VERB
admet-2043	618	11	neuronal	neuronal	ADJ
admet-2043	618	12	damage	damage	NOUN
admet-2043	618	13	brought	bring	VERB
admet-2043	618	14	on	on	ADP
admet-2043	618	15	by	by	ADP
admet-2043	618	16	bbb	bbb	PROPN
admet-2043	618	17	rupture	rupture	NOUN
admet-2043	618	18	,	,	PUNCT
admet-2043	618	19	innovative	innovative	ADJ
admet-2043	618	20	drug	drug	NOUN
admet-2043	618	21	modification	modification	NOUN
admet-2043	618	22	tactics	tactic	NOUN
admet-2043	618	23	might	might	AUX
admet-2043	618	24	be	be	AUX
admet-2043	618	25	extremely	extremely	ADV
admet-2043	618	26	important	important	ADJ
admet-2043	618	27	.	.	PUNCT
admet-2043	619	1	lipid	lipid	NOUN
admet-2043	619	2	-	-	PUNCT
admet-2043	619	3	based	base	VERB
admet-2043	619	4	nms	nms	NOUN
admet-2043	619	5	have	have	AUX
admet-2043	619	6	demonstrated	demonstrate	VERB
admet-2043	619	7	potential	potential	ADJ
admet-2043	619	8	as	as	ADP
admet-2043	619	9	a	a	DET
admet-2043	619	10	secure	secure	ADJ
admet-2043	619	11	and	and	CCONJ
admet-2043	619	12	efficient	efficient	ADJ
admet-2043	619	13	way	way	NOUN
admet-2043	619	14	to	to	PART
admet-2043	619	15	penetrate	penetrate	VERB
admet-2043	619	16	the	the	DET
admet-2043	619	17	bbb	bbb	NOUN
admet-2043	619	18	[	[	X
admet-2043	619	19	176	176	NUM
admet-2043	619	20	]	]	PUNCT
admet-2043	619	21	.	.	PUNCT
admet-2043	620	1	after	after	ADP
admet-2043	620	2	administering	administer	VERB
admet-2043	620	3	nms	nms	NOUN
admet-2043	620	4	for	for	ADP
admet-2043	620	5	bbb	bbb	PROPN
admet-2043	620	6	drug	drug	NOUN
admet-2043	620	7	delivery	delivery	NOUN
admet-2043	620	8	,	,	PUNCT
admet-2043	620	9	it	it	PRON
admet-2043	620	10	is	be	AUX
admet-2043	620	11	important	important	ADJ
admet-2043	620	12	to	to	PART
admet-2043	620	13	consider	consider	VERB
admet-2043	620	14	their	their	PRON
admet-2043	620	15	potential	potential	ADJ
admet-2043	620	16	systemic	systemic	ADJ
admet-2043	620	17	toxicity	toxicity	NOUN
admet-2043	620	18	.	.	PUNCT
admet-2043	621	1	when	when	SCONJ
admet-2043	621	2	nms	nms	PROPN
admet-2043	621	3	are	be	AUX
admet-2043	621	4	administered	administer	VERB
admet-2043	621	5	,	,	PUNCT
admet-2043	621	6	they	they	PRON
admet-2043	621	7	can	can	AUX
admet-2043	621	8	undergo	undergo	VERB
admet-2043	621	9	various	various	ADJ
admet-2043	621	10	processes	process	NOUN
admet-2043	621	11	such	such	ADJ
admet-2043	621	12	as	as	ADP
admet-2043	621	13	absorption	absorption	NOUN
admet-2043	621	14	,	,	PUNCT
admet-2043	621	15	distribution	distribution	NOUN
admet-2043	621	16	,	,	PUNCT
admet-2043	621	17	metabolism	metabolism	NOUN
admet-2043	621	18	,	,	PUNCT
admet-2043	621	19	and	and	CCONJ
admet-2043	621	20	excretion	excretion	NOUN
admet-2043	621	21	(	(	PUNCT
admet-2043	621	22	adme	adme	NOUN
admet-2043	621	23	)	)	PUNCT
admet-2043	621	24	within	within	ADP
admet-2043	621	25	the	the	DET
admet-2043	621	26	body	body	NOUN
admet-2043	621	27	.	.	PUNCT
admet-2043	622	1	although	although	SCONJ
admet-2043	622	2	nms	nms	NOUN
admet-2043	622	3	offer	offer	VERB
admet-2043	622	4	promising	promising	ADJ
admet-2043	622	5	benefits	benefit	NOUN
admet-2043	622	6	,	,	PUNCT
admet-2043	622	7	it	it	PRON
admet-2043	622	8	is	be	AUX
admet-2043	622	9	necessary	necessary	ADJ
admet-2043	622	10	to	to	PART
admet-2043	622	11	assess	assess	VERB
admet-2043	622	12	their	their	PRON
admet-2043	622	13	adverse	adverse	ADJ
admet-2043	622	14	effects	effect	NOUN
admet-2043	622	15	on	on	ADP
admet-2043	622	16	organs	organ	NOUN
admet-2043	622	17	and	and	CCONJ
admet-2043	622	18	tissues	tissue	NOUN
admet-2043	622	19	beyond	beyond	ADP
admet-2043	622	20	the	the	DET
admet-2043	622	21	targeted	target	VERB
admet-2043	622	22	site	site	NOUN
admet-2043	622	23	.	.	PUNCT
admet-2043	623	1	the	the	DET
admet-2043	623	2	biodistribution	biodistribution	NOUN
admet-2043	623	3	and	and	CCONJ
admet-2043	623	4	accumulation	accumulation	NOUN
admet-2043	623	5	of	of	ADP
admet-2043	623	6	nms	nms	NOUN
admet-2043	623	7	can	can	AUX
admet-2043	623	8	be	be	AUX
admet-2043	623	9	influenced	influence	VERB
admet-2043	623	10	by	by	ADP
admet-2043	623	11	size	size	NOUN
admet-2043	623	12	,	,	PUNCT
admet-2043	623	13	surface	surface	NOUN
admet-2043	623	14	properties	property	NOUN
admet-2043	623	15	,	,	PUNCT
admet-2043	623	16	and	and	CCONJ
admet-2043	623	17	targeting	target	VERB
admet-2043	623	18	ligands	ligand	NOUN
admet-2043	623	19	,	,	PUNCT
admet-2043	623	20	which	which	PRON
admet-2043	623	21	influence	influence	VERB
admet-2043	623	22	the	the	DET
admet-2043	623	23	distribution	distribution	NOUN
admet-2043	623	24	and	and	CCONJ
admet-2043	623	25	accumulation	accumulation	NOUN
admet-2043	623	26	of	of	ADP
admet-2043	623	27	nanomaterials	nanomaterial	NOUN
admet-2043	623	28	in	in	ADP
admet-2043	623	29	various	various	ADJ
admet-2043	623	30	body	body	NOUN
admet-2043	623	31	areas	area	NOUN
admet-2043	623	32	.	.	PUNCT
admet-2043	624	1	accumulation	accumulation	NOUN
admet-2043	624	2	in	in	ADP
admet-2043	624	3	unintended	unintended	ADJ
admet-2043	624	4	organs	organ	NOUN
admet-2043	624	5	,	,	PUNCT
admet-2043	624	6	such	such	ADJ
admet-2043	624	7	as	as	ADP
admet-2043	624	8	the	the	DET
admet-2043	624	9	liver	liver	NOUN
admet-2043	624	10	,	,	PUNCT
admet-2043	624	11	spleen	spleen	NOUN
admet-2043	624	12	,	,	PUNCT
admet-2043	624	13	and	and	CCONJ
admet-2043	624	14	lungs	lung	NOUN
admet-2043	624	15	,	,	PUNCT
admet-2043	624	16	raises	raise	VERB
admet-2043	624	17	concerns	concern	NOUN
admet-2043	624	18	about	about	ADP
admet-2043	624	19	off	off	ADP
admet-2043	624	20	-	-	PUNCT
admet-2043	624	21	target	target	NOUN
admet-2043	624	22	effects	effect	NOUN
admet-2043	624	23	.	.	PUNCT
admet-2043	625	1	additionally	additionally	ADV
admet-2043	625	2	,	,	PUNCT
admet-2043	625	3	specific	specific	ADJ
admet-2043	625	4	types	type	NOUN
admet-2043	625	5	of	of	ADP
admet-2043	625	6	nms	nms	NOUN
admet-2043	625	7	,	,	PUNCT
admet-2043	625	8	like	like	ADP
admet-2043	625	9	carbon	carbon	NOUN
admet-2043	625	10	-	-	PUNCT
admet-2043	625	11	based	base	VERB
admet-2043	625	12	ones	one	NOUN
admet-2043	625	13	[	[	X
admet-2043	625	14	177	177	NUM
admet-2043	625	15	]	]	PUNCT
admet-2043	625	16	,	,	PUNCT
admet-2043	625	17	have	have	AUX
admet-2043	625	18	shown	show	VERB
admet-2043	625	19	potential	potential	ADJ
admet-2043	625	20	toxicity	toxicity	NOUN
admet-2043	625	21	in	in	ADP
admet-2043	625	22	the	the	DET
admet-2043	625	23	lungs	lung	NOUN
admet-2043	625	24	,	,	PUNCT
admet-2043	625	25	immune	immune	ADJ
admet-2043	625	26	system	system	NOUN
admet-2043	625	27	,	,	PUNCT
admet-2043	625	28	and	and	CCONJ
admet-2043	625	29	liver	liver	NOUN
admet-2043	625	30	.	.	PUNCT
admet-2043	626	1	since	since	SCONJ
admet-2043	626	2	the	the	DET
admet-2043	626	3	brain	brain	NOUN
admet-2043	626	4	is	be	AUX
admet-2043	626	5	the	the	DET
admet-2043	626	6	intended	intend	VERB
admet-2043	626	7	target	target	NOUN
admet-2043	626	8	,	,	PUNCT
admet-2043	626	9	evaluating	evaluate	VERB
admet-2043	626	10	neurotoxicity	neurotoxicity	NOUN
admet-2043	626	11	is	be	AUX
admet-2043	626	12	crucial	crucial	ADJ
admet-2043	626	13	.	.	PUNCT
admet-2043	627	1	this	this	PRON
admet-2043	627	2	includes	include	VERB
admet-2043	627	3	assessing	assess	VERB
admet-2043	627	4	potential	potential	ADJ
admet-2043	627	5	neuronal	neuronal	ADJ
admet-2043	627	6	cell	cell	NOUN
admet-2043	627	7	death	death	NOUN
admet-2043	627	8	and	and	CCONJ
admet-2043	627	9	disruptions	disruption	NOUN
admet-2043	627	10	in	in	ADP
admet-2043	627	11	neurodevelopment	neurodevelopment	NOUN
admet-2043	627	12	caused	cause	VERB
admet-2043	627	13	by	by	ADP
admet-2043	627	14	nanomaterial	nanomaterial	ADJ
admet-2043	627	15	exposure	exposure	NOUN
admet-2043	627	16	[	[	X
admet-2043	627	17	178	178	NUM
admet-2043	627	18	]	]	PUNCT
admet-2043	627	19	.	.	PUNCT
admet-2043	628	1	intranasal	intranasal	PROPN
admet-2043	628	2	administration	administration	NOUN
admet-2043	628	3	has	have	AUX
admet-2043	628	4	become	become	VERB
admet-2043	628	5	a	a	DET
admet-2043	628	6	potential	potential	ADJ
admet-2043	628	7	and	and	CCONJ
admet-2043	628	8	non	non	ADJ
admet-2043	628	9	-	-	ADJ
admet-2043	628	10	invasive	invasive	ADJ
admet-2043	628	11	alternative	alternative	NOUN
admet-2043	628	12	to	to	ADP
admet-2043	628	13	conventional	conventional	ADJ
admet-2043	628	14	parenteral	parenteral	ADJ
admet-2043	628	15	methods	method	NOUN
admet-2043	628	16	for	for	ADP
admet-2043	628	17	medication	medication	NOUN
admet-2043	628	18	delivery	delivery	NOUN
admet-2043	628	19	to	to	ADP
admet-2043	628	20	the	the	DET
admet-2043	628	21	brain	brain	NOUN
admet-2043	628	22	.	.	PUNCT
admet-2043	629	1	this	this	DET
admet-2043	629	2	form	form	NOUN
admet-2043	629	3	of	of	ADP
admet-2043	629	4	administration	administration	NOUN
admet-2043	629	5	has	have	VERB
admet-2043	629	6	a	a	DET
admet-2043	629	7	number	number	NOUN
admet-2043	629	8	of	of	ADP
admet-2043	629	9	benefits	benefit	NOUN
admet-2043	629	10	,	,	PUNCT
admet-2043	629	11	including	include	VERB
admet-2043	629	12	preventing	prevent	VERB
admet-2043	629	13	hepatic	hepatic	ADJ
admet-2043	629	14	metabolism	metabolism	NOUN
admet-2043	629	15	,	,	PUNCT
admet-2043	629	16	lowering	lower	VERB
admet-2043	629	17	drug	drug	NOUN
admet-2043	629	18	buildup	buildup	NOUN
admet-2043	629	19	in	in	ADP
admet-2043	629	20	non	non	ADJ
admet-2043	629	21	-	-	ADJ
admet-2043	629	22	target	target	ADJ
admet-2043	629	23	organs	organ	NOUN
admet-2043	629	24	,	,	PUNCT
admet-2043	629	25	and	and	CCONJ
admet-2043	629	26	decreasing	decrease	VERB
admet-2043	629	27	systemic	systemic	ADJ
admet-2043	629	28	adverse	adverse	ADJ
admet-2043	629	29	effects	effect	NOUN
admet-2043	629	30	.	.	PUNCT
admet-2043	630	1	due	due	ADP
admet-2043	630	2	to	to	ADP
admet-2043	630	3	its	its	PRON
admet-2043	630	4	early	early	ADJ
admet-2043	630	5	start	start	NOUN
admet-2043	630	6	of	of	ADP
admet-2043	630	7	the	the	DET
admet-2043	630	8	effect	effect	NOUN
admet-2043	630	9	,	,	PUNCT
admet-2043	630	10	quick	quick	ADJ
admet-2043	630	11	absorption	absorption	NOUN
admet-2043	630	12	,	,	PUNCT
admet-2043	630	13	non	non	ADJ
admet-2043	630	14	-	-	ADJ
admet-2043	630	15	invasiveness	invasiveness	ADJ
admet-2043	630	16	,	,	PUNCT
admet-2043	630	17	absence	absence	NOUN
admet-2043	630	18	of	of	ADP
admet-2043	630	19	tissue	tissue	NOUN
admet-2043	630	20	damage	damage	NOUN
admet-2043	630	21	,	,	PUNCT
admet-2043	630	22	and	and	CCONJ
admet-2043	630	23	convenience	convenience	NOUN
admet-2043	630	24	of	of	ADP
admet-2043	630	25	usage	usage	NOUN
admet-2043	630	26	,	,	PUNCT
admet-2043	630	27	intranasal	intranasal	ADJ
admet-2043	630	28	medication	medication	NOUN
admet-2043	630	29	delivery	delivery	NOUN
admet-2043	630	30	is	be	AUX
admet-2043	630	31	often	often	ADV
admet-2043	630	32	employed	employ	VERB
admet-2043	630	33	[	[	X
admet-2043	630	34	179,180	179,180	NUM
admet-2043	630	35	]	]	PUNCT
admet-2043	630	36	.	.	PUNCT
admet-2043	631	1	in	in	ADP
admet-2043	631	2	a	a	DET
admet-2043	631	3	study	study	NOUN
admet-2043	631	4	conducted	conduct	VERB
admet-2043	631	5	by	by	ADP
admet-2043	631	6	choi	choi	PROPN
admet-2043	631	7	et	et	PROPN
admet-2043	631	8	al	al	PROPN
admet-2043	631	9	.	.	PUNCT
admet-2043	632	1	[	[	X
admet-2043	632	2	181	181	NUM
admet-2043	632	3	]	]	PUNCT
admet-2043	632	4	,	,	PUNCT
admet-2043	632	5	the	the	DET
admet-2043	632	6	biodistribution	biodistribution	NOUN
admet-2043	632	7	of	of	ADP
admet-2043	632	8	polymeric	polymeric	ADJ
admet-2043	632	9	nms	nms	NOUN
admet-2043	632	10	was	be	AUX
admet-2043	632	11	investigated	investigate	VERB
admet-2043	632	12	in	in	ADP
admet-2043	632	13	mice	mouse	NOUN
admet-2043	632	14	by	by	ADP
admet-2043	632	15	intravenous	intravenous	ADJ
admet-2043	632	16	injection	injection	NOUN
admet-2043	632	17	.	.	PUNCT
admet-2043	633	1	the	the	DET
admet-2043	633	2	findings	finding	NOUN
admet-2043	633	3	revealed	reveal	VERB
admet-2043	633	4	that	that	SCONJ
admet-2043	633	5	the	the	DET
admet-2043	633	6	nms	nms	NOUN
admet-2043	633	7	predominantly	predominantly	ADV
admet-2043	633	8	accumulated	accumulate	VERB
admet-2043	633	9	in	in	ADP
admet-2043	633	10	the	the	DET
admet-2043	633	11	liver	liver	NOUN
admet-2043	633	12	and	and	CCONJ
admet-2043	633	13	spleen	spleen	NOUN
admet-2043	633	14	,	,	PUNCT
admet-2043	633	15	suggesting	suggest	VERB
admet-2043	633	16	the	the	DET
admet-2043	633	17	possibility	possibility	NOUN
admet-2043	633	18	of	of	ADP
admet-2043	633	19	off	off	ADP
admet-2043	633	20	-	-	PUNCT
admet-2043	633	21	target	target	NOUN
admet-2043	633	22	effects	effect	NOUN
admet-2043	633	23	in	in	ADP
admet-2043	633	24	these	these	DET
admet-2043	633	25	organs	organ	NOUN
admet-2043	633	26	.	.	PUNCT
admet-2043	634	1	the	the	DET
admet-2043	634	2	study	study	NOUN
admet-2043	634	3	highlighted	highlight	VERB
admet-2043	634	4	the	the	DET
admet-2043	634	5	importance	importance	NOUN
admet-2043	634	6	of	of	ADP
admet-2043	634	7	understanding	understand	VERB
admet-2043	634	8	the	the	DET
admet-2043	634	9	distribution	distribution	NOUN
admet-2043	634	10	patterns	pattern	NOUN
admet-2043	634	11	of	of	ADP
admet-2043	634	12	nms	nms	NOUN
admet-2043	634	13	within	within	ADP
admet-2043	634	14	the	the	DET
admet-2043	634	15	body	body	NOUN
admet-2043	634	16	to	to	PART
admet-2043	634	17	assess	assess	VERB
admet-2043	634	18	their	their	PRON
admet-2043	634	19	potential	potential	ADJ
admet-2043	634	20	impact	impact	NOUN
admet-2043	634	21	on	on	ADP
admet-2043	634	22	nontargeted	nontargete	VERB
admet-2043	634	23	organs	organ	NOUN
admet-2043	634	24	.	.	PUNCT
admet-2043	635	1	this	this	DET
admet-2043	635	2	information	information	NOUN
admet-2043	635	3	is	be	AUX
admet-2043	635	4	crucial	crucial	ADJ
admet-2043	635	5	in	in	ADP
admet-2043	635	6	the	the	DET
admet-2043	635	7	development	development	NOUN
admet-2043	635	8	of	of	ADP
admet-2043	635	9	drug	drug	NOUN
admet-2043	635	10	delivery	delivery	NOUN
admet-2043	635	11	systems	system	NOUN
admet-2043	635	12	to	to	PART
admet-2043	635	13	minimize	minimize	VERB
admet-2043	635	14	offtarget	offtarget	NOUN
admet-2043	635	15	effects	effect	NOUN
admet-2043	635	16	and	and	CCONJ
admet-2043	635	17	maximize	maximize	VERB
admet-2043	635	18	therapeutic	therapeutic	ADJ
admet-2043	635	19	efficacy	efficacy	NOUN
admet-2043	635	20	[	[	X
admet-2043	635	21	181	181	NUM
admet-2043	635	22	]	]	PUNCT
admet-2043	635	23	.	.	PUNCT
admet-2043	636	1	j.	j.	PROPN
admet-2043	636	2	duan	duan	PROPN
admet-2043	636	3	et	et	PROPN
admet-2043	636	4	al	al	PROPN
admet-2043	636	5	.	.	PUNCT
admet-2043	637	1	[	[	X
admet-2043	637	2	182	182	NUM
admet-2043	637	3	]	]	PUNCT
admet-2043	637	4	conducted	conduct	VERB
admet-2043	637	5	a	a	DET
admet-2043	637	6	study	study	NOUN
admet-2043	637	7	in	in	ADP
admet-2043	637	8	2021	2021	NUM
admet-2043	637	9	to	to	PART
admet-2043	637	10	investigate	investigate	VERB
admet-2043	637	11	the	the	DET
admet-2043	637	12	potential	potential	ADJ
admet-2043	637	13	neurotoxicity	neurotoxicity	NOUN
admet-2043	637	14	of	of	ADP
admet-2043	637	15	silica	silica	NOUN
admet-2043	637	16	nms	nms	NOUN
admet-2043	637	17	using	use	VERB
admet-2043	637	18	zebrafish	zebrafish	ADJ
admet-2043	637	19	models	model	NOUN
admet-2043	637	20	.	.	PUNCT
admet-2043	638	1	the	the	DET
admet-2043	638	2	study	study	NOUN
admet-2043	638	3	aimed	aim	VERB
admet-2043	638	4	to	to	PART
admet-2043	638	5	assess	assess	VERB
admet-2043	638	6	the	the	DET
admet-2043	638	7	effects	effect	NOUN
admet-2043	638	8	of	of	ADP
admet-2043	638	9	exposure	exposure	NOUN
admet-2043	638	10	to	to	PART
admet-2043	638	11	silica	silica	VERB
admet-2043	638	12	nms	nms	NOUN
admet-2043	638	13	on	on	ADP
admet-2043	638	14	neuronal	neuronal	ADJ
admet-2043	638	15	cells	cell	NOUN
admet-2043	638	16	and	and	CCONJ
admet-2043	638	17	neurodevelopment	neurodevelopment	ADJ
admet-2043	638	18	.	.	PUNCT
admet-2043	639	1	the	the	DET
admet-2043	639	2	investigations	investigation	NOUN
admet-2043	639	3	revealed	reveal	VERB
admet-2043	639	4	that	that	SCONJ
admet-2043	639	5	exposure	exposure	NOUN
admet-2043	639	6	to	to	ADP
admet-2043	639	7	silica	silica	NOUN
admet-2043	639	8	nms	nms	NOUN
admet-2043	639	9	resulted	result	VERB
admet-2043	639	10	in	in	ADP
admet-2043	639	11	neuronal	neuronal	ADJ
admet-2043	639	12	cell	cell	NOUN
admet-2043	639	13	death	death	NOUN
admet-2043	639	14	admet	admet	PROPN
admet-2043	639	15	&	&	CCONJ
admet-2043	639	16	dmpk	dmpk	PROPN
admet-2043	639	17	12(1	12(1	PROPN
admet-2043	639	18	)	)	PUNCT
admet-2043	639	19	(	(	PUNCT
admet-2043	639	20	2024	2024	NUM
admet-2043	639	21	)	)	PUNCT
admet-2043	639	22	63	63	NUM
admet-2043	639	23	-	-	SYM
admet-2043	639	24	105	105	NUM
admet-2043	639	25	nanomaterials	nanomaterial	NOUN
admet-2043	639	26	as	as	ADP
admet-2043	639	27	drug	drug	NOUN
admet-2043	639	28	delivery	delivery	NOUN
admet-2043	639	29	agents	agent	NOUN
admet-2043	639	30	for	for	ADP
admet-2043	639	31	overcoming	overcome	VERB
admet-2043	639	32	bbb	bbb	PROPN
admet-2043	639	33	doi	doi	NOUN
admet-2043	639	34	:	:	PUNCT
admet-2043	639	35	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	639	36	87	87	NUM
admet-2043	639	37	and	and	CCONJ
admet-2043	639	38	disrupted	disrupt	VERB
admet-2043	639	39	normal	normal	ADJ
admet-2043	639	40	neurodevelopment	neurodevelopment	ADJ
admet-2043	639	41	processes	process	NOUN
admet-2043	639	42	.	.	PUNCT
admet-2043	640	1	these	these	DET
admet-2043	640	2	findings	finding	NOUN
admet-2043	640	3	emphasize	emphasize	VERB
admet-2043	640	4	the	the	DET
admet-2043	640	5	importance	importance	NOUN
admet-2043	640	6	of	of	ADP
admet-2043	640	7	conducting	conduct	VERB
admet-2043	640	8	thorough	thorough	ADJ
admet-2043	640	9	evaluations	evaluation	NOUN
admet-2043	640	10	and	and	CCONJ
admet-2043	640	11	assessments	assessment	NOUN
admet-2043	640	12	of	of	ADP
admet-2043	640	13	nanomaterials	nanomaterial	NOUN
admet-2043	640	14	for	for	ADP
admet-2043	640	15	drug	drug	NOUN
admet-2043	640	16	delivery	delivery	NOUN
admet-2043	640	17	to	to	ADP
admet-2043	640	18	the	the	DET
admet-2043	640	19	brain	brain	NOUN
admet-2043	640	20	.	.	PUNCT
admet-2043	641	1	it	it	PRON
admet-2043	641	2	highlights	highlight	VERB
admet-2043	641	3	the	the	DET
admet-2043	641	4	need	need	NOUN
admet-2043	641	5	for	for	ADP
admet-2043	641	6	careful	careful	ADJ
admet-2043	641	7	consideration	consideration	NOUN
admet-2043	641	8	of	of	ADP
admet-2043	641	9	potential	potential	ADJ
admet-2043	641	10	neurotoxic	neurotoxic	ADJ
admet-2043	641	11	effects	effect	NOUN
admet-2043	641	12	when	when	SCONJ
admet-2043	641	13	designing	design	VERB
admet-2043	641	14	and	and	CCONJ
admet-2043	641	15	selecting	select	VERB
admet-2043	641	16	nms	nms	NOUN
admet-2043	641	17	for	for	ADP
admet-2043	641	18	brain	brain	NOUN
admet-2043	641	19	drug	drug	NOUN
admet-2043	641	20	delivery	delivery	NOUN
admet-2043	641	21	strategies	strategy	NOUN
admet-2043	641	22	to	to	PART
admet-2043	641	23	ensure	ensure	VERB
admet-2043	641	24	the	the	DET
admet-2043	641	25	safety	safety	NOUN
admet-2043	641	26	and	and	CCONJ
admet-2043	641	27	efficacy	efficacy	NOUN
admet-2043	641	28	of	of	ADP
admet-2043	641	29	therapeutic	therapeutic	ADJ
admet-2043	641	30	interventions	intervention	NOUN
admet-2043	641	31	[	[	X
admet-2043	641	32	182	182	NUM
admet-2043	641	33	]	]	PUNCT
admet-2043	641	34	.	.	PUNCT
admet-2043	642	1	safety	safety	NOUN
admet-2043	642	2	measures	measure	NOUN
admet-2043	642	3	for	for	ADP
admet-2043	642	4	nanomaterials	nanomaterial	NOUN
admet-2043	642	5	in	in	ADP
admet-2043	642	6	drug	drug	NOUN
admet-2043	642	7	delivery	delivery	NOUN
admet-2043	642	8	to	to	ADP
admet-2043	642	9	bbb	bbb	PROPN
admet-2043	642	10	the	the	DET
admet-2043	642	11	potential	potential	NOUN
admet-2043	642	12	of	of	ADP
admet-2043	642	13	nms	nms	NOUN
admet-2043	642	14	as	as	ADP
admet-2043	642	15	drug	drug	NOUN
admet-2043	642	16	delivery	delivery	NOUN
admet-2043	642	17	systems	system	NOUN
admet-2043	642	18	to	to	PART
admet-2043	642	19	penetrate	penetrate	VERB
admet-2043	642	20	the	the	DET
admet-2043	642	21	bbb	bbb	NOUN
admet-2043	642	22	and	and	CCONJ
admet-2043	642	23	treat	treat	VERB
admet-2043	642	24	neurological	neurological	ADJ
admet-2043	642	25	disorders	disorder	NOUN
admet-2043	642	26	is	be	AUX
admet-2043	642	27	immense	immense	ADJ
admet-2043	642	28	.	.	PUNCT
admet-2043	643	1	however	however	ADV
admet-2043	643	2	,	,	PUNCT
admet-2043	643	3	ensuring	ensure	VERB
admet-2043	643	4	the	the	DET
admet-2043	643	5	safety	safety	NOUN
admet-2043	643	6	of	of	ADP
admet-2043	643	7	these	these	DET
admet-2043	643	8	nms	nms	NOUN
admet-2043	643	9	is	be	AUX
admet-2043	643	10	crucial	crucial	ADJ
admet-2043	643	11	for	for	ADP
admet-2043	643	12	their	their	PRON
admet-2043	643	13	effective	effective	ADJ
admet-2043	643	14	and	and	CCONJ
admet-2043	643	15	safe	safe	ADJ
admet-2043	643	16	utilization	utilization	NOUN
admet-2043	643	17	.	.	PUNCT
admet-2043	644	1	surface	surface	NOUN
admet-2043	644	2	modification	modification	NOUN
admet-2043	644	3	and	and	CCONJ
admet-2043	644	4	rational	rational	ADJ
admet-2043	644	5	design	design	NOUN
admet-2043	644	6	strategies	strategy	NOUN
admet-2043	644	7	significantly	significantly	ADV
admet-2043	644	8	enhance	enhance	VERB
admet-2043	644	9	the	the	DET
admet-2043	644	10	safety	safety	NOUN
admet-2043	644	11	profile	profile	NOUN
admet-2043	644	12	of	of	ADP
admet-2043	644	13	nms	nms	PROPN
admet-2043	644	14	in	in	ADP
admet-2043	644	15	bbb	bbb	PROPN
admet-2043	644	16	drug	drug	NOUN
admet-2043	644	17	delivery	delivery	NOUN
admet-2043	644	18	[	[	X
admet-2043	644	19	168	168	NUM
admet-2043	644	20	]	]	PUNCT
admet-2043	644	21	.	.	PUNCT
admet-2043	645	1	this	this	PRON
admet-2043	645	2	will	will	AUX
admet-2043	645	3	focus	focus	VERB
admet-2043	645	4	on	on	ADP
admet-2043	645	5	the	the	DET
admet-2043	645	6	importance	importance	NOUN
admet-2043	645	7	of	of	ADP
admet-2043	645	8	safety	safety	NOUN
admet-2043	645	9	measures	measure	NOUN
admet-2043	645	10	,	,	PUNCT
admet-2043	645	11	particularly	particularly	ADV
admet-2043	645	12	rational	rational	ADJ
admet-2043	645	13	design	design	NOUN
admet-2043	645	14	and	and	CCONJ
admet-2043	645	15	surface	surface	NOUN
admet-2043	645	16	modification	modification	NOUN
admet-2043	645	17	,	,	PUNCT
admet-2043	645	18	in	in	ADP
admet-2043	645	19	enhancing	enhance	VERB
admet-2043	645	20	the	the	DET
admet-2043	645	21	safety	safety	NOUN
admet-2043	645	22	and	and	CCONJ
admet-2043	645	23	efficacy	efficacy	NOUN
admet-2043	645	24	of	of	ADP
admet-2043	645	25	nms	nms	NOUN
admet-2043	645	26	for	for	ADP
admet-2043	645	27	crossing	cross	VERB
admet-2043	645	28	the	the	DET
admet-2043	645	29	bbb	bbb	PROPN
admet-2043	645	30	.	.	PUNCT
admet-2043	646	1	it	it	PRON
admet-2043	646	2	will	will	AUX
admet-2043	646	3	explore	explore	VERB
admet-2043	646	4	specific	specific	ADJ
admet-2043	646	5	techniques	technique	NOUN
admet-2043	646	6	such	such	ADJ
admet-2043	646	7	as	as	ADP
admet-2043	646	8	pegylation	pegylation	NOUN
admet-2043	646	9	,	,	PUNCT
admet-2043	646	10	coating	coat	VERB
admet-2043	646	11	nms	nms	NOUN
admet-2043	646	12	with	with	ADP
admet-2043	646	13	biocompatible	biocompatible	ADJ
admet-2043	646	14	polymers	polymer	NOUN
admet-2043	646	15	,	,	PUNCT
admet-2043	646	16	and	and	CCONJ
admet-2043	646	17	ligand	ligand	VERB
admet-2043	646	18	targeting	target	VERB
admet-2043	646	19	,	,	PUNCT
admet-2043	646	20	highlighting	highlight	VERB
admet-2043	646	21	their	their	PRON
admet-2043	646	22	potential	potential	NOUN
admet-2043	646	23	to	to	PART
admet-2043	646	24	minimize	minimize	VERB
admet-2043	646	25	nanomaterial	nanomaterial	ADJ
admet-2043	646	26	toxicity	toxicity	NOUN
admet-2043	646	27	[	[	X
admet-2043	646	28	183	183	NUM
admet-2043	646	29	]	]	PUNCT
admet-2043	646	30	.	.	PUNCT
admet-2043	647	1	additionally	additionally	ADV
admet-2043	647	2	,	,	PUNCT
admet-2043	647	3	the	the	DET
admet-2043	647	4	review	review	NOUN
admet-2043	647	5	covers	cover	VERB
admet-2043	647	6	preclinical	preclinical	ADJ
admet-2043	647	7	safety	safety	NOUN
admet-2043	647	8	evaluation	evaluation	NOUN
admet-2043	647	9	methods	method	NOUN
admet-2043	647	10	and	and	CCONJ
admet-2043	647	11	regulatory	regulatory	ADJ
admet-2043	647	12	considerations	consideration	NOUN
admet-2043	647	13	for	for	ADP
admet-2043	647	14	nms	nms	PROPN
admet-2043	647	15	in	in	ADP
admet-2043	647	16	brain	brain	NOUN
admet-2043	647	17	drug	drug	NOUN
admet-2043	647	18	delivery	delivery	NOUN
admet-2043	647	19	,	,	PUNCT
admet-2043	647	20	providing	provide	VERB
admet-2043	647	21	a	a	DET
admet-2043	647	22	comprehensive	comprehensive	ADJ
admet-2043	647	23	understanding	understanding	NOUN
admet-2043	647	24	of	of	ADP
admet-2043	647	25	the	the	DET
admet-2043	647	26	safety	safety	NOUN
admet-2043	647	27	aspects	aspect	NOUN
admet-2043	647	28	associated	associate	VERB
admet-2043	647	29	with	with	ADP
admet-2043	647	30	using	use	VERB
admet-2043	647	31	nms	nms	NOUN
admet-2043	647	32	for	for	ADP
admet-2043	647	33	bbb	bbb	PROPN
admet-2043	647	34	drug	drug	NOUN
admet-2043	647	35	delivery	delivery	NOUN
admet-2043	647	36	systems	system	NOUN
admet-2043	647	37	.	.	PUNCT
admet-2043	648	1	pegylation	pegylation	NOUN
admet-2043	648	2	is	be	AUX
admet-2043	648	3	a	a	DET
admet-2043	648	4	widely	widely	ADV
admet-2043	648	5	adopted	adopt	VERB
admet-2043	648	6	technique	technique	NOUN
admet-2043	648	7	in	in	ADP
admet-2043	648	8	nanomedicine	nanomedicine	NOUN
admet-2043	648	9	,	,	PUNCT
admet-2043	648	10	involving	involve	VERB
admet-2043	648	11	the	the	DET
admet-2043	648	12	attachment	attachment	NOUN
admet-2043	648	13	of	of	ADP
admet-2043	648	14	polyethylene	polyethylene	NOUN
admet-2043	648	15	glycol	glycol	NOUN
admet-2043	648	16	(	(	PUNCT
admet-2043	648	17	peg	peg	NOUN
admet-2043	648	18	)	)	PUNCT
admet-2043	648	19	chains	chain	NOUN
admet-2043	648	20	to	to	ADP
admet-2043	648	21	nanomaterial	nanomaterial	ADJ
admet-2043	648	22	surfaces	surface	NOUN
admet-2043	648	23	,	,	PUNCT
admet-2043	648	24	which	which	PRON
admet-2043	648	25	creates	create	VERB
admet-2043	648	26	a	a	DET
admet-2043	648	27	hydrophilic	hydrophilic	ADJ
admet-2043	648	28	shield	shield	NOUN
admet-2043	648	29	around	around	ADP
admet-2043	648	30	the	the	DET
admet-2043	648	31	nanomaterial	nanomaterial	NOUN
admet-2043	648	32	,	,	PUNCT
admet-2043	648	33	mitigating	mitigate	VERB
admet-2043	648	34	recognition	recognition	NOUN
admet-2043	648	35	and	and	CCONJ
admet-2043	648	36	clearance	clearance	NOUN
admet-2043	648	37	by	by	ADP
admet-2043	648	38	the	the	DET
admet-2043	648	39	immune	immune	ADJ
admet-2043	648	40	system	system	NOUN
admet-2043	648	41	.	.	PUNCT
admet-2043	649	1	this	this	DET
admet-2043	649	2	reduction	reduction	NOUN
admet-2043	649	3	in	in	ADP
admet-2043	649	4	immune	immune	ADJ
admet-2043	649	5	response	response	NOUN
admet-2043	649	6	enhances	enhance	VERB
admet-2043	649	7	biocompatibility	biocompatibility	NOUN
admet-2043	649	8	and	and	CCONJ
admet-2043	649	9	minimizes	minimize	VERB
admet-2043	649	10	the	the	DET
admet-2043	649	11	risk	risk	NOUN
admet-2043	649	12	of	of	ADP
admet-2043	649	13	adverse	adverse	ADJ
admet-2043	649	14	reactions	reaction	NOUN
admet-2043	649	15	.	.	PUNCT
admet-2043	650	1	pegylation	pegylation	NOUN
admet-2043	650	2	also	also	ADV
admet-2043	650	3	contributes	contribute	VERB
admet-2043	650	4	to	to	ADP
admet-2043	650	5	diminished	diminished	ADJ
admet-2043	650	6	interactions	interaction	NOUN
admet-2043	650	7	between	between	ADP
admet-2043	650	8	nms	nms	NOUN
admet-2043	650	9	and	and	CCONJ
admet-2043	650	10	biological	biological	ADJ
admet-2043	650	11	components	component	NOUN
admet-2043	650	12	,	,	PUNCT
admet-2043	650	13	reducing	reduce	VERB
admet-2043	650	14	cellular	cellular	ADJ
admet-2043	650	15	uptake	uptake	NOUN
admet-2043	650	16	and	and	CCONJ
admet-2043	650	17	potential	potential	ADJ
admet-2043	650	18	toxicity	toxicity	NOUN
admet-2043	650	19	.	.	PUNCT
admet-2043	651	1	the	the	DET
admet-2043	651	2	steric	steric	ADJ
admet-2043	651	3	hindrance	hindrance	NOUN
admet-2043	651	4	provided	provide	VERB
admet-2043	651	5	by	by	ADP
admet-2043	651	6	peg	peg	NOUN
admet-2043	651	7	chains	chain	NOUN
admet-2043	651	8	prevents	prevent	VERB
admet-2043	651	9	nanomaterial	nanomaterial	ADJ
admet-2043	651	10	aggregation	aggregation	NOUN
admet-2043	651	11	,	,	PUNCT
admet-2043	651	12	ensuring	ensure	VERB
admet-2043	651	13	improved	improved	ADJ
admet-2043	651	14	stability	stability	NOUN
admet-2043	651	15	in	in	ADP
admet-2043	651	16	biological	biological	ADJ
admet-2043	651	17	environments	environment	NOUN
admet-2043	651	18	.	.	PUNCT
admet-2043	652	1	moreover	moreover	ADV
admet-2043	652	2	,	,	PUNCT
admet-2043	652	3	pegylation	pegylation	NOUN
admet-2043	652	4	extends	extend	VERB
admet-2043	652	5	the	the	DET
admet-2043	652	6	circulation	circulation	NOUN
admet-2043	652	7	time	time	NOUN
admet-2043	652	8	of	of	ADP
admet-2043	652	9	nms	nms	NOUN
admet-2043	652	10	in	in	ADP
admet-2043	652	11	the	the	DET
admet-2043	652	12	bloodstream	bloodstream	NOUN
admet-2043	652	13	,	,	PUNCT
admet-2043	652	14	facilitating	facilitate	VERB
admet-2043	652	15	prolonged	prolonged	ADJ
admet-2043	652	16	drug	drug	NOUN
admet-2043	652	17	delivery	delivery	NOUN
admet-2043	652	18	to	to	ADP
admet-2043	652	19	the	the	DET
admet-2043	652	20	brain	brain	NOUN
admet-2043	652	21	.	.	PUNCT
admet-2043	653	1	additionally	additionally	ADV
admet-2043	653	2	,	,	PUNCT
admet-2043	653	3	surface	surface	NOUN
admet-2043	653	4	coating	coating	NOUN
admet-2043	653	5	with	with	ADP
admet-2043	653	6	biocompatible	biocompatible	ADJ
admet-2043	653	7	polymers	polymer	NOUN
admet-2043	653	8	represents	represent	VERB
admet-2043	653	9	another	another	DET
admet-2043	653	10	strategy	strategy	NOUN
admet-2043	653	11	to	to	PART
admet-2043	653	12	enhance	enhance	VERB
admet-2043	653	13	the	the	DET
admet-2043	653	14	safety	safety	NOUN
admet-2043	653	15	of	of	ADP
admet-2043	653	16	nms	nms	PROPN
admet-2043	653	17	in	in	ADP
admet-2043	653	18	bbb	bbb	PROPN
admet-2043	653	19	drug	drug	NOUN
admet-2043	653	20	delivery	delivery	NOUN
admet-2043	653	21	[	[	X
admet-2043	653	22	168,184,185	168,184,185	NUM
admet-2043	653	23	]	]	X
admet-2043	653	24	.	.	PUNCT
admet-2043	654	1	polyethyleneimine	polyethyleneimine	PROPN
admet-2043	654	2	(	(	PUNCT
admet-2043	654	3	pei	pei	PROPN
admet-2043	654	4	):	):	PUNCT
admet-2043	654	5	coating	coat	VERB
admet-2043	654	6	nms	nms	PROPN
admet-2043	654	7	with	with	ADP
admet-2043	654	8	pei	pei	PROPN
admet-2043	654	9	imparts	impart	VERB
admet-2043	654	10	a	a	DET
admet-2043	654	11	positive	positive	ADJ
admet-2043	654	12	surface	surface	NOUN
admet-2043	654	13	charge	charge	NOUN
admet-2043	654	14	,	,	PUNCT
admet-2043	654	15	enhancing	enhance	VERB
admet-2043	654	16	cellular	cellular	ADJ
admet-2043	654	17	uptake	uptake	NOUN
admet-2043	654	18	and	and	CCONJ
admet-2043	654	19	transport	transport	NOUN
admet-2043	654	20	across	across	ADP
admet-2043	654	21	the	the	DET
admet-2043	654	22	bbb	bbb	PROPN
admet-2043	654	23	.	.	PUNCT
admet-2043	655	1	pei	pei	PROPN
admet-2043	655	2	coatings	coating	NOUN
admet-2043	655	3	also	also	ADV
admet-2043	655	4	protect	protect	VERB
admet-2043	655	5	nms	nms	NOUN
admet-2043	655	6	from	from	ADP
admet-2043	655	7	degradation	degradation	NOUN
admet-2043	655	8	and	and	CCONJ
admet-2043	655	9	reduce	reduce	VERB
admet-2043	655	10	their	their	PRON
admet-2043	655	11	potential	potential	ADJ
admet-2043	655	12	toxicity	toxicity	NOUN
admet-2043	655	13	[	[	X
admet-2043	655	14	186,187	186,187	NUM
admet-2043	655	15	]	]	PUNCT
admet-2043	655	16	.	.	PUNCT
admet-2043	656	1	chitosan	chitosan	NOUN
admet-2043	656	2	:	:	PUNCT
admet-2043	657	1	chitosan	chitosan	NOUN
admet-2043	657	2	,	,	PUNCT
admet-2043	657	3	a	a	DET
admet-2043	657	4	natural	natural	ADJ
admet-2043	657	5	polysaccharide	polysaccharide	NOUN
admet-2043	657	6	,	,	PUNCT
admet-2043	657	7	is	be	AUX
admet-2043	657	8	frequently	frequently	ADV
admet-2043	657	9	used	use	VERB
admet-2043	657	10	for	for	ADP
admet-2043	657	11	surface	surface	NOUN
admet-2043	657	12	modification	modification	NOUN
admet-2043	657	13	of	of	ADP
admet-2043	657	14	nms	nms	NOUN
admet-2043	657	15	.	.	PUNCT
admet-2043	658	1	it	it	PRON
admet-2043	658	2	forms	form	VERB
admet-2043	658	3	a	a	DET
admet-2043	658	4	protective	protective	ADJ
admet-2043	658	5	layer	layer	NOUN
admet-2043	658	6	,	,	PUNCT
admet-2043	658	7	improves	improve	VERB
admet-2043	658	8	stability	stability	NOUN
admet-2043	658	9	,	,	PUNCT
admet-2043	658	10	and	and	CCONJ
admet-2043	658	11	reduces	reduce	VERB
admet-2043	658	12	interactions	interaction	NOUN
admet-2043	658	13	with	with	ADP
admet-2043	658	14	biological	biological	ADJ
admet-2043	658	15	components	component	NOUN
admet-2043	658	16	,	,	PUNCT
admet-2043	658	17	thereby	thereby	ADV
admet-2043	658	18	enhancing	enhance	VERB
admet-2043	658	19	biocompatibility	biocompatibility	NOUN
admet-2043	658	20	and	and	CCONJ
admet-2043	658	21	minimizing	minimize	VERB
admet-2043	658	22	cytotoxicity	cytotoxicity	NOUN
admet-2043	658	23	[	[	X
admet-2043	658	24	183	183	NUM
admet-2043	658	25	]	]	PUNCT
admet-2043	658	26	.	.	PUNCT
admet-2043	659	1	ligand	ligand	PROPN
admet-2043	659	2	targeting	target	VERB
admet-2043	659	3	:	:	PUNCT
admet-2043	659	4	ligand	ligand	ADJ
admet-2043	659	5	targeting	target	VERB
admet-2043	659	6	involves	involve	NOUN
admet-2043	659	7	attaching	attach	VERB
admet-2043	659	8	specific	specific	ADJ
admet-2043	659	9	ligands	ligand	NOUN
admet-2043	659	10	to	to	ADP
admet-2043	659	11	the	the	DET
admet-2043	659	12	surface	surface	NOUN
admet-2043	659	13	of	of	ADP
admet-2043	659	14	nms	nms	NOUN
admet-2043	659	15	to	to	PART
admet-2043	659	16	facilitate	facilitate	VERB
admet-2043	659	17	their	their	PRON
admet-2043	659	18	interaction	interaction	NOUN
admet-2043	659	19	with	with	ADP
admet-2043	659	20	receptors	receptor	NOUN
admet-2043	659	21	or	or	CCONJ
admet-2043	659	22	transporters	transporter	NOUN
admet-2043	659	23	in	in	ADP
admet-2043	659	24	the	the	DET
admet-2043	659	25	bbb	bbb	PROPN
admet-2043	659	26	.	.	PUNCT
admet-2043	660	1	this	this	DET
admet-2043	660	2	surface	surface	NOUN
admet-2043	660	3	modification	modification	NOUN
admet-2043	660	4	technique	technique	NOUN
admet-2043	660	5	enables	enable	VERB
admet-2043	660	6	targeted	target	VERB
admet-2043	660	7	drug	drug	NOUN
admet-2043	660	8	delivery	delivery	NOUN
admet-2043	660	9	and	and	CCONJ
admet-2043	660	10	reduces	reduce	VERB
admet-2043	660	11	off	off	ADP
admet-2043	660	12	-	-	PUNCT
admet-2043	660	13	target	target	NOUN
admet-2043	660	14	effects	effect	NOUN
admet-2043	660	15	[	[	X
admet-2043	660	16	188	188	NUM
admet-2043	660	17	]	]	PUNCT
admet-2043	660	18	.	.	PUNCT
admet-2043	661	1	targeting	target	VERB
admet-2043	661	2	bbb	bbb	NOUN
admet-2043	661	3	receptors	receptor	NOUN
admet-2043	661	4	/	/	SYM
admet-2043	661	5	transporters	transporter	NOUN
admet-2043	661	6	:	:	PUNCT
admet-2043	661	7	conjugating	conjugate	VERB
admet-2043	661	8	ligands	ligand	NOUN
admet-2043	661	9	that	that	PRON
admet-2043	661	10	can	can	AUX
admet-2043	661	11	bind	bind	VERB
admet-2043	661	12	to	to	ADP
admet-2043	661	13	receptors	receptor	NOUN
admet-2043	661	14	or	or	CCONJ
admet-2043	661	15	transporters	transporter	NOUN
admet-2043	661	16	expressed	express	VERB
admet-2043	661	17	in	in	ADP
admet-2043	661	18	the	the	DET
admet-2043	661	19	bbb	bbb	PROPN
admet-2043	661	20	allows	allow	VERB
admet-2043	661	21	nms	nms	PROPN
admet-2043	661	22	to	to	PART
admet-2043	661	23	selectively	selectively	ADV
admet-2043	661	24	interact	interact	VERB
admet-2043	661	25	with	with	ADP
admet-2043	661	26	these	these	DET
admet-2043	661	27	specific	specific	ADJ
admet-2043	661	28	sites	site	NOUN
admet-2043	661	29	,	,	PUNCT
admet-2043	661	30	facilitating	facilitate	VERB
admet-2043	661	31	their	their	PRON
admet-2043	661	32	transport	transport	NOUN
admet-2043	661	33	across	across	ADP
admet-2043	661	34	the	the	DET
admet-2043	661	35	barrier	barrier	NOUN
admet-2043	661	36	and	and	CCONJ
admet-2043	661	37	enhancing	enhance	VERB
admet-2043	661	38	drug	drug	NOUN
admet-2043	661	39	delivery	delivery	NOUN
admet-2043	661	40	to	to	ADP
admet-2043	661	41	the	the	DET
admet-2043	661	42	brain	brain	NOUN
admet-2043	662	1	[	[	X
admet-2043	662	2	183	183	NUM
admet-2043	662	3	]	]	PUNCT
admet-2043	662	4	.	.	PUNCT
admet-2043	662	5	enhanced	enhance	VERB
admet-2043	662	6	efficiency	efficiency	NOUN
admet-2043	662	7	and	and	CCONJ
admet-2043	662	8	reduced	reduce	VERB
admet-2043	662	9	systemic	systemic	ADJ
admet-2043	662	10	toxicity	toxicity	NOUN
admet-2043	662	11	:	:	PUNCT
admet-2043	662	12	ligand	ligand	NOUN
admet-2043	662	13	-	-	PUNCT
admet-2043	662	14	mediated	mediate	VERB
admet-2043	662	15	targeting	targeting	NOUN
admet-2043	662	16	improves	improve	VERB
admet-2043	662	17	drug	drug	NOUN
admet-2043	662	18	delivery	delivery	NOUN
admet-2043	662	19	efficiency	efficiency	NOUN
admet-2043	662	20	by	by	ADP
admet-2043	662	21	increasing	increase	VERB
admet-2043	662	22	therapeutics	therapeutic	NOUN
admet-2043	662	23	accumulation	accumulation	NOUN
admet-2043	662	24	at	at	ADP
admet-2043	662	25	the	the	DET
admet-2043	662	26	desired	desire	VERB
admet-2043	662	27	site	site	NOUN
admet-2043	662	28	while	while	SCONJ
admet-2043	662	29	minimizing	minimize	VERB
admet-2043	662	30	their	their	PRON
admet-2043	662	31	distribution	distribution	NOUN
admet-2043	662	32	to	to	ADP
admet-2043	662	33	non	non	ADJ
admet-2043	662	34	-	-	ADJ
admet-2043	662	35	target	target	ADJ
admet-2043	662	36	tissues	tissue	NOUN
admet-2043	662	37	.	.	PUNCT
admet-2043	663	1	this	this	DET
admet-2043	663	2	approach	approach	NOUN
admet-2043	663	3	reduces	reduce	VERB
admet-2043	663	4	systemic	systemic	ADJ
admet-2043	663	5	toxicity	toxicity	NOUN
admet-2043	663	6	and	and	CCONJ
admet-2043	663	7	improves	improve	VERB
admet-2043	663	8	the	the	DET
admet-2043	663	9	therapeutic	therapeutic	ADJ
admet-2043	663	10	index	index	NOUN
admet-2043	663	11	[	[	X
admet-2043	663	12	183	183	NUM
admet-2043	663	13	]	]	PUNCT
admet-2043	663	14	.	.	PUNCT
admet-2043	664	1	ensuring	ensure	VERB
admet-2043	664	2	the	the	DET
admet-2043	664	3	safety	safety	NOUN
admet-2043	664	4	of	of	ADP
admet-2043	664	5	nanomaterials	nanomaterial	NOUN
admet-2043	664	6	intended	intend	VERB
admet-2043	664	7	for	for	ADP
admet-2043	664	8	brain	brain	NOUN
admet-2043	664	9	drug	drug	NOUN
admet-2043	664	10	delivery	delivery	NOUN
admet-2043	664	11	is	be	AUX
admet-2043	664	12	critical	critical	ADJ
admet-2043	664	13	to	to	ADP
admet-2043	664	14	their	their	PRON
admet-2043	664	15	development	development	NOUN
admet-2043	664	16	.	.	PUNCT
admet-2043	665	1	comprehensive	comprehensive	ADJ
admet-2043	665	2	safety	safety	NOUN
admet-2043	665	3	evaluations	evaluation	NOUN
admet-2043	665	4	involve	involve	VERB
admet-2043	665	5	a	a	DET
admet-2043	665	6	multifaceted	multifaceted	ADJ
admet-2043	665	7	approach	approach	NOUN
admet-2043	665	8	,	,	PUNCT
admet-2043	665	9	encompassing	encompass	VERB
admet-2043	665	10	both	both	CCONJ
admet-2043	665	11	in	in	ADP
admet-2043	665	12	vitro	vitro	X
admet-2043	665	13	assays	assay	NOUN
admet-2043	665	14	and	and	CCONJ
admet-2043	665	15	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	665	16	m.	m.	NOUN
admet-2043	666	1	kulkarni	kulkarni	PROPN
admet-2043	666	2	et	et	PROPN
admet-2043	666	3	al	al	PROPN
admet-2043	666	4	.	.	PROPN
admet-2043	666	5	admet	admet	PROPN
admet-2043	666	6	&	&	CCONJ
admet-2043	666	7	dmpk	dmpk	PROPN
admet-2043	666	8	12(1	12(1	PROPN
admet-2043	666	9	)	)	PUNCT
admet-2043	666	10	(	(	PUNCT
admet-2043	666	11	2024	2024	NUM
admet-2043	666	12	)	)	PUNCT
admet-2043	666	13	63	63	NUM
admet-2043	666	14	-	-	SYM
admet-2043	666	15	105	105	NUM
admet-2043	666	16	88	88	NUM
admet-2043	666	17	animal	animal	NOUN
admet-2043	666	18	models	model	NOUN
admet-2043	666	19	,	,	PUNCT
admet-2043	666	20	alongside	alongside	ADP
admet-2043	666	21	adherence	adherence	NOUN
admet-2043	666	22	to	to	ADP
admet-2043	666	23	regulatory	regulatory	ADJ
admet-2043	666	24	considerations	consideration	NOUN
admet-2043	666	25	.	.	PUNCT
admet-2043	667	1	in	in	ADP
admet-2043	667	2	vitro	vitro	X
admet-2043	667	3	assays	assay	NOUN
admet-2043	667	4	play	play	VERB
admet-2043	667	5	a	a	DET
admet-2043	667	6	pivotal	pivotal	ADJ
admet-2043	667	7	role	role	NOUN
admet-2043	667	8	,	,	PUNCT
admet-2043	667	9	encompassing	encompass	VERB
admet-2043	667	10	tests	test	NOUN
admet-2043	667	11	for	for	ADP
admet-2043	667	12	cytotoxicity	cytotoxicity	NOUN
admet-2043	667	13	,	,	PUNCT
admet-2043	667	14	cellular	cellular	ADJ
admet-2043	667	15	uptake	uptake	NOUN
admet-2043	667	16	,	,	PUNCT
admet-2043	667	17	reactive	reactive	ADJ
admet-2043	667	18	oxygen	oxygen	NOUN
admet-2043	667	19	species	specie	NOUN
admet-2043	667	20	(	(	PUNCT
admet-2043	667	21	ros	ros	PROPN
admet-2043	667	22	)	)	PUNCT
admet-2043	667	23	generation	generation	NOUN
admet-2043	667	24	,	,	PUNCT
admet-2043	667	25	and	and	CCONJ
admet-2043	667	26	bloodbrain	bloodbrain	NOUN
admet-2043	667	27	barrier	barrier	NOUN
admet-2043	667	28	(	(	PUNCT
admet-2043	667	29	bbb	bbb	NOUN
admet-2043	667	30	)	)	PUNCT
admet-2043	667	31	permeability	permeability	NOUN
admet-2043	667	32	.	.	PUNCT
admet-2043	668	1	researchers	researcher	NOUN
admet-2043	668	2	also	also	ADV
admet-2043	668	3	delve	delve	VERB
admet-2043	668	4	into	into	ADP
admet-2043	668	5	how	how	SCONJ
admet-2043	668	6	nanomaterial	nanomaterial	ADJ
admet-2043	668	7	design	design	NOUN
admet-2043	668	8	and	and	CCONJ
admet-2043	668	9	surface	surface	NOUN
admet-2043	668	10	modifications	modification	NOUN
admet-2043	668	11	impact	impact	VERB
admet-2043	668	12	these	these	PRON
admet-2043	668	13	in	in	ADP
admet-2043	668	14	vitro	vitro	X
admet-2043	668	15	safety	safety	NOUN
admet-2043	668	16	assessments	assessment	NOUN
admet-2043	668	17	[	[	X
admet-2043	668	18	189	189	NUM
admet-2043	668	19	]	]	PUNCT
admet-2043	668	20	.	.	PUNCT
admet-2043	669	1	animal	animal	NOUN
admet-2043	669	2	models	model	NOUN
admet-2043	669	3	,	,	PUNCT
admet-2043	669	4	particularly	particularly	ADV
admet-2043	669	5	rodents	rodent	NOUN
admet-2043	669	6	such	such	ADJ
admet-2043	669	7	as	as	ADP
admet-2043	669	8	mice	mouse	NOUN
admet-2043	669	9	and	and	CCONJ
admet-2043	669	10	rats	rat	NOUN
admet-2043	669	11	models	model	NOUN
admet-2043	669	12	,	,	PUNCT
admet-2043	669	13	enable	enable	VERB
admet-2043	669	14	the	the	DET
admet-2043	669	15	assessment	assessment	NOUN
admet-2043	669	16	of	of	ADP
admet-2043	669	17	acute	acute	ADJ
admet-2043	669	18	and	and	CCONJ
admet-2043	669	19	chronic	chronic	ADJ
admet-2043	669	20	toxicities	toxicity	NOUN
admet-2043	669	21	,	,	PUNCT
admet-2043	669	22	distribution	distribution	NOUN
admet-2043	669	23	patterns	pattern	NOUN
admet-2043	669	24	,	,	PUNCT
admet-2043	669	25	and	and	CCONJ
admet-2043	669	26	long	long	ADJ
admet-2043	669	27	-	-	PUNCT
admet-2043	669	28	term	term	NOUN
admet-2043	669	29	effects	effect	NOUN
admet-2043	669	30	.	.	PUNCT
admet-2043	670	1	neurobehavioral	neurobehavioral	ADJ
admet-2043	670	2	assessments	assessment	NOUN
admet-2043	670	3	,	,	PUNCT
admet-2043	670	4	histopathological	histopathological	ADJ
admet-2043	670	5	analyses	analysis	NOUN
admet-2043	670	6	,	,	PUNCT
admet-2043	670	7	and	and	CCONJ
admet-2043	670	8	biodistribution	biodistribution	NOUN
admet-2043	670	9	studies	study	NOUN
admet-2043	670	10	collectively	collectively	ADV
admet-2043	670	11	contribute	contribute	VERB
admet-2043	670	12	to	to	ADP
admet-2043	670	13	a	a	DET
admet-2043	670	14	thorough	thorough	ADJ
admet-2043	670	15	understanding	understanding	NOUN
admet-2043	670	16	of	of	ADP
admet-2043	670	17	the	the	DET
admet-2043	670	18	safety	safety	NOUN
admet-2043	670	19	profile	profile	NOUN
admet-2043	670	20	of	of	ADP
admet-2043	670	21	nms	nms	NOUN
admet-2043	670	22	[	[	X
admet-2043	670	23	168,190	168,190	NUM
admet-2043	670	24	]	]	PUNCT
admet-2043	670	25	.	.	PUNCT
admet-2043	671	1	importance	importance	NOUN
admet-2043	671	2	of	of	ADP
admet-2043	671	3	long	long	ADJ
admet-2043	671	4	-	-	PUNCT
admet-2043	671	5	term	term	NOUN
admet-2043	671	6	effects	effect	NOUN
admet-2043	671	7	,	,	PUNCT
admet-2043	671	8	immunotoxicity	immunotoxicity	NOUN
admet-2043	671	9	and	and	CCONJ
admet-2043	671	10	genotoxicity	genotoxicity	NOUN
admet-2043	671	11	:	:	PUNCT
admet-2043	671	12	regulatory	regulatory	ADJ
admet-2043	671	13	authorities	authority	NOUN
admet-2043	671	14	emphasize	emphasize	VERB
admet-2043	671	15	the	the	DET
admet-2043	671	16	assessment	assessment	NOUN
admet-2043	671	17	of	of	ADP
admet-2043	671	18	long	long	ADJ
admet-2043	671	19	-	-	PUNCT
admet-2043	671	20	term	term	NOUN
admet-2043	671	21	effects	effect	NOUN
admet-2043	671	22	,	,	PUNCT
admet-2043	671	23	immunotoxicity	immunotoxicity	NOUN
admet-2043	671	24	[	[	X
admet-2043	671	25	188	188	NUM
admet-2043	671	26	]	]	PUNCT
admet-2043	671	27	,	,	PUNCT
admet-2043	671	28	and	and	CCONJ
admet-2043	671	29	genotoxicity	genotoxicity	NOUN
admet-2043	671	30	during	during	ADP
admet-2043	671	31	the	the	DET
admet-2043	671	32	safety	safety	NOUN
admet-2043	671	33	evaluation	evaluation	NOUN
admet-2043	671	34	of	of	ADP
admet-2043	671	35	nms	nms	NOUN
admet-2043	671	36	for	for	ADP
admet-2043	671	37	brain	brain	NOUN
admet-2043	671	38	drug	drug	NOUN
admet-2043	671	39	delivery	delivery	NOUN
admet-2043	671	40	.	.	PUNCT
admet-2043	672	1	understanding	understand	VERB
admet-2043	672	2	the	the	DET
admet-2043	672	3	potential	potential	ADJ
admet-2043	672	4	risks	risk	NOUN
admet-2043	672	5	associated	associate	VERB
admet-2043	672	6	with	with	ADP
admet-2043	672	7	prolonged	prolonged	ADJ
admet-2043	672	8	exposure	exposure	NOUN
admet-2043	672	9	,	,	PUNCT
admet-2043	672	10	immune	immune	ADJ
admet-2043	672	11	responses	response	NOUN
admet-2043	672	12	,	,	PUNCT
admet-2043	672	13	and	and	CCONJ
admet-2043	672	14	dna	dna	PROPN
admet-2043	672	15	damage	damage	NOUN
admet-2043	672	16	is	be	AUX
admet-2043	672	17	crucial	crucial	ADJ
admet-2043	672	18	for	for	ADP
admet-2043	672	19	obtaining	obtain	VERB
admet-2043	672	20	regulatory	regulatory	ADJ
admet-2043	672	21	approval	approval	NOUN
admet-2043	672	22	.	.	PUNCT
admet-2043	673	1	comprehensive	comprehensive	ADJ
admet-2043	673	2	evaluations	evaluation	NOUN
admet-2043	673	3	are	be	AUX
admet-2043	673	4	necessary	necessary	ADJ
admet-2043	673	5	to	to	PART
admet-2043	673	6	ensure	ensure	VERB
admet-2043	673	7	the	the	DET
admet-2043	673	8	safe	safe	ADJ
admet-2043	673	9	translation	translation	NOUN
admet-2043	673	10	of	of	ADP
admet-2043	673	11	nanomaterial	nanomaterial	NOUN
admet-2043	673	12	-	-	PUNCT
admet-2043	673	13	based	base	VERB
admet-2043	673	14	drug	drug	NOUN
admet-2043	673	15	delivery	delivery	NOUN
admet-2043	673	16	systems	system	NOUN
admet-2043	673	17	for	for	ADP
admet-2043	673	18	brain	brain	NOUN
admet-2043	673	19	disorders	disorder	NOUN
admet-2043	673	20	[	[	X
admet-2043	673	21	191	191	NUM
admet-2043	673	22	]	]	PUNCT
admet-2043	673	23	.	.	PUNCT
admet-2043	674	1	regulatory	regulatory	ADJ
admet-2043	674	2	guidance	guidance	NOUN
admet-2043	674	3	and	and	CCONJ
admet-2043	674	4	reviews	review	NOUN
admet-2043	674	5	:	:	PUNCT
admet-2043	674	6	several	several	ADJ
admet-2043	674	7	regulatory	regulatory	ADJ
admet-2043	674	8	guidelines	guideline	NOUN
admet-2043	674	9	provide	provide	VERB
admet-2043	674	10	comprehensive	comprehensive	ADJ
admet-2043	674	11	frameworks	framework	NOUN
admet-2043	674	12	for	for	ADP
admet-2043	674	13	evaluating	evaluate	VERB
admet-2043	674	14	the	the	DET
admet-2043	674	15	safety	safety	NOUN
admet-2043	674	16	of	of	ADP
admet-2043	674	17	nanomaterials	nanomaterial	NOUN
admet-2043	674	18	.	.	PUNCT
admet-2043	675	1	the	the	DET
admet-2043	675	2	international	international	ADJ
admet-2043	675	3	council	council	PROPN
admet-2043	675	4	for	for	ADP
admet-2043	675	5	harmonisation	harmonisation	NOUN
admet-2043	675	6	(	(	PUNCT
admet-2043	675	7	ich	ich	NOUN
admet-2043	675	8	)	)	PUNCT
admet-2043	675	9	guidelines	guideline	NOUN
admet-2043	675	10	,	,	PUNCT
admet-2043	675	11	the	the	DET
admet-2043	675	12	u.s	u.s	PROPN
admet-2043	675	13	.	.	PROPN
admet-2043	675	14	food	food	PROPN
admet-2043	675	15	and	and	CCONJ
admet-2043	675	16	drug	drug	PROPN
admet-2043	675	17	administration	administration	PROPN
admet-2043	675	18	(	(	PUNCT
admet-2043	675	19	fda	fda	PROPN
admet-2043	675	20	)	)	PUNCT
admet-2043	675	21	nanotechnology	nanotechnology	PROPN
admet-2043	675	22	initiatives	initiative	NOUN
admet-2043	675	23	[	[	X
admet-2043	675	24	192	192	NUM
admet-2043	675	25	]	]	PUNCT
admet-2043	675	26	and	and	CCONJ
admet-2043	675	27	the	the	DET
admet-2043	675	28	european	european	PROPN
admet-2043	675	29	medicines	medicines	PROPN
admet-2043	675	30	agency	agency	NOUN
admet-2043	675	31	(	(	PUNCT
admet-2043	675	32	ema	ema	PROPN
admet-2043	675	33	)	)	PUNCT
admet-2043	675	34	guidelines	guideline	NOUN
admet-2043	675	35	offer	offer	VERB
admet-2043	675	36	valuable	valuable	ADJ
admet-2043	675	37	guidance	guidance	NOUN
admet-2043	675	38	for	for	ADP
admet-2043	675	39	nanomaterial	nanomaterial	ADJ
admet-2043	675	40	safety	safety	NOUN
admet-2043	675	41	assessments	assessment	NOUN
admet-2043	675	42	.	.	PUNCT
admet-2043	676	1	additionally	additionally	ADV
admet-2043	676	2	,	,	PUNCT
admet-2043	676	3	reviews	review	NOUN
admet-2043	676	4	and	and	CCONJ
admet-2043	676	5	studies	study	NOUN
admet-2043	676	6	focus	focus	VERB
admet-2043	676	7	on	on	ADP
admet-2043	676	8	safety	safety	NOUN
admet-2043	676	9	evaluation	evaluation	NOUN
admet-2043	676	10	methodologies	methodology	NOUN
admet-2043	676	11	,	,	PUNCT
admet-2043	676	12	contributing	contribute	VERB
admet-2043	676	13	valuable	valuable	ADJ
admet-2043	676	14	insights	insight	NOUN
admet-2043	676	15	into	into	ADP
admet-2043	676	16	regulatory	regulatory	ADJ
admet-2043	676	17	considerations	consideration	NOUN
admet-2043	676	18	[	[	X
admet-2043	676	19	193	193	NUM
admet-2043	676	20	]	]	PUNCT
admet-2043	676	21	.	.	PUNCT
admet-2043	677	1	by	by	ADP
admet-2043	677	2	implementing	implement	VERB
admet-2043	677	3	rational	rational	ADJ
admet-2043	677	4	design	design	NOUN
admet-2043	677	5	and	and	CCONJ
admet-2043	677	6	surface	surface	NOUN
admet-2043	677	7	modification	modification	NOUN
admet-2043	677	8	strategies	strategy	NOUN
admet-2043	677	9	,	,	PUNCT
admet-2043	677	10	the	the	DET
admet-2043	677	11	safety	safety	NOUN
admet-2043	677	12	profile	profile	NOUN
admet-2043	677	13	of	of	ADP
admet-2043	677	14	nanomaterials	nanomaterial	NOUN
admet-2043	677	15	for	for	ADP
admet-2043	677	16	bbb	bbb	PROPN
admet-2043	677	17	drug	drug	NOUN
admet-2043	677	18	delivery	delivery	NOUN
admet-2043	677	19	can	can	AUX
admet-2043	677	20	be	be	AUX
admet-2043	677	21	improved	improve	VERB
admet-2043	677	22	.	.	PUNCT
admet-2043	678	1	approaches	approach	NOUN
admet-2043	678	2	such	such	ADJ
admet-2043	678	3	as	as	ADP
admet-2043	678	4	pegylation	pegylation	NOUN
admet-2043	678	5	,	,	PUNCT
admet-2043	678	6	surface	surface	NOUN
admet-2043	678	7	coating	coating	NOUN
admet-2043	678	8	with	with	ADP
admet-2043	678	9	biocompatible	biocompatible	ADJ
admet-2043	678	10	polymers	polymer	NOUN
admet-2043	678	11	,	,	PUNCT
admet-2043	678	12	and	and	CCONJ
admet-2043	678	13	ligand	ligand	NOUN
admet-2043	678	14	targeting	target	VERB
admet-2043	678	15	show	show	NOUN
admet-2043	678	16	promise	promise	NOUN
admet-2043	678	17	in	in	ADP
admet-2043	678	18	minimizing	minimize	VERB
admet-2043	678	19	nanomaterial	nanomaterial	ADJ
admet-2043	678	20	toxicity	toxicity	NOUN
admet-2043	678	21	.	.	PUNCT
admet-2043	679	1	in	in	ADP
admet-2043	679	2	vitro	vitro	X
admet-2043	679	3	assays	assay	NOUN
admet-2043	679	4	and	and	CCONJ
admet-2043	679	5	animal	animal	NOUN
admet-2043	679	6	models	model	NOUN
admet-2043	679	7	serve	serve	VERB
admet-2043	679	8	as	as	ADP
admet-2043	679	9	important	important	ADJ
admet-2043	679	10	tools	tool	NOUN
admet-2043	679	11	for	for	ADP
admet-2043	679	12	safety	safety	NOUN
admet-2043	679	13	evaluation	evaluation	NOUN
admet-2043	679	14	[	[	X
admet-2043	679	15	192	192	NUM
admet-2043	679	16	]	]	PUNCT
admet-2043	679	17	,	,	PUNCT
admet-2043	679	18	while	while	SCONJ
admet-2043	679	19	regulatory	regulatory	ADJ
admet-2043	679	20	guidelines	guideline	NOUN
admet-2043	679	21	emphasize	emphasize	VERB
admet-2043	679	22	the	the	DET
admet-2043	679	23	assessment	assessment	NOUN
admet-2043	679	24	of	of	ADP
admet-2043	679	25	long	long	ADJ
admet-2043	679	26	-	-	PUNCT
admet-2043	679	27	term	term	NOUN
admet-2043	679	28	effects	effect	NOUN
admet-2043	679	29	,	,	PUNCT
admet-2043	679	30	immunotoxicity	immunotoxicity	NOUN
admet-2043	679	31	,	,	PUNCT
admet-2043	679	32	and	and	CCONJ
admet-2043	679	33	genotoxicity	genotoxicity	NOUN
admet-2043	679	34	.	.	PUNCT
admet-2043	680	1	a	a	DET
admet-2043	680	2	comprehensive	comprehensive	ADJ
admet-2043	680	3	understanding	understanding	NOUN
admet-2043	680	4	of	of	ADP
admet-2043	680	5	these	these	DET
admet-2043	680	6	safety	safety	NOUN
admet-2043	680	7	measures	measure	NOUN
admet-2043	680	8	is	be	AUX
admet-2043	680	9	essential	essential	ADJ
admet-2043	680	10	for	for	ADP
admet-2043	680	11	the	the	DET
admet-2043	680	12	successful	successful	ADJ
admet-2043	680	13	translation	translation	NOUN
admet-2043	680	14	of	of	ADP
admet-2043	680	15	nanomaterial	nanomaterial	NOUN
admet-2043	680	16	-	-	PUNCT
admet-2043	680	17	based	base	VERB
admet-2043	680	18	drug	drug	NOUN
admet-2043	680	19	delivery	delivery	NOUN
admet-2043	680	20	systems	system	NOUN
admet-2043	680	21	for	for	ADP
admet-2043	680	22	brain	brain	NOUN
admet-2043	680	23	disorders	disorder	NOUN
admet-2043	680	24	.	.	PUNCT
admet-2043	681	1	in	in	ADP
admet-2043	681	2	summary	summary	NOUN
admet-2043	681	3	,	,	PUNCT
admet-2043	681	4	the	the	DET
admet-2043	681	5	rational	rational	ADJ
admet-2043	681	6	design	design	NOUN
admet-2043	681	7	and	and	CCONJ
admet-2043	681	8	surface	surface	NOUN
admet-2043	681	9	modification	modification	NOUN
admet-2043	681	10	strategies	strategy	NOUN
admet-2043	681	11	significantly	significantly	ADV
admet-2043	681	12	enhance	enhance	VERB
admet-2043	681	13	the	the	DET
admet-2043	681	14	safety	safety	NOUN
admet-2043	681	15	profile	profile	NOUN
admet-2043	681	16	of	of	ADP
admet-2043	681	17	nanomaterials	nanomaterial	NOUN
admet-2043	681	18	intended	intend	VERB
admet-2043	681	19	for	for	ADP
admet-2043	681	20	bbb	bbb	PROPN
admet-2043	681	21	drug	drug	NOUN
admet-2043	681	22	delivery	delivery	NOUN
admet-2043	681	23	.	.	PUNCT
admet-2043	682	1	key	key	ADJ
admet-2043	682	2	approaches	approach	NOUN
admet-2043	682	3	such	such	ADJ
admet-2043	682	4	as	as	ADP
admet-2043	682	5	pegylation	pegylation	NOUN
admet-2043	682	6	,	,	PUNCT
admet-2043	682	7	surface	surface	NOUN
admet-2043	682	8	coating	coating	NOUN
admet-2043	682	9	with	with	ADP
admet-2043	682	10	biocompatible	biocompatible	ADJ
admet-2043	682	11	polymers	polymer	NOUN
admet-2043	682	12	,	,	PUNCT
admet-2043	682	13	and	and	CCONJ
admet-2043	682	14	ligand	ligand	NOUN
admet-2043	682	15	targeting	target	VERB
admet-2043	682	16	have	have	AUX
admet-2043	682	17	shown	show	VERB
admet-2043	682	18	promise	promise	NOUN
admet-2043	682	19	in	in	ADP
admet-2043	682	20	minimizing	minimize	VERB
admet-2043	682	21	nanomaterial	nanomaterial	ADJ
admet-2043	682	22	toxicity	toxicity	NOUN
admet-2043	682	23	and	and	CCONJ
admet-2043	682	24	improving	improve	VERB
admet-2043	682	25	their	their	PRON
admet-2043	682	26	efficacy	efficacy	NOUN
admet-2043	682	27	.	.	PUNCT
admet-2043	683	1	pegylation	pegylation	NOUN
admet-2043	683	2	,	,	PUNCT
admet-2043	683	3	a	a	DET
admet-2043	683	4	widely	widely	ADV
admet-2043	683	5	adopted	adopt	VERB
admet-2043	683	6	technique	technique	NOUN
admet-2043	683	7	,	,	PUNCT
admet-2043	683	8	involves	involve	VERB
admet-2043	683	9	attaching	attach	VERB
admet-2043	683	10	polyethylene	polyethylene	NOUN
admet-2043	683	11	glycol	glycol	NOUN
admet-2043	683	12	(	(	PUNCT
admet-2043	683	13	peg	peg	NOUN
admet-2043	683	14	)	)	PUNCT
admet-2043	683	15	chains	chain	NOUN
admet-2043	683	16	to	to	ADP
admet-2043	683	17	nanomaterial	nanomaterial	ADJ
admet-2043	683	18	surfaces	surface	NOUN
admet-2043	683	19	,	,	PUNCT
admet-2043	683	20	creating	create	VERB
admet-2043	683	21	a	a	DET
admet-2043	683	22	hydrophilic	hydrophilic	ADJ
admet-2043	683	23	shield	shield	NOUN
admet-2043	683	24	to	to	PART
admet-2043	683	25	reduce	reduce	VERB
admet-2043	683	26	immune	immune	ADJ
admet-2043	683	27	recognition	recognition	NOUN
admet-2043	683	28	and	and	CCONJ
admet-2043	683	29	clearance	clearance	NOUN
admet-2043	683	30	.	.	PUNCT
admet-2043	684	1	this	this	DET
admet-2043	684	2	approach	approach	NOUN
admet-2043	684	3	enhances	enhance	VERB
admet-2043	684	4	biocompatibility	biocompatibility	NOUN
admet-2043	684	5	,	,	PUNCT
admet-2043	684	6	minimizes	minimize	VERB
admet-2043	684	7	potential	potential	ADJ
admet-2043	684	8	toxicity	toxicity	NOUN
admet-2043	684	9	,	,	PUNCT
admet-2043	684	10	and	and	CCONJ
admet-2043	684	11	extends	extend	VERB
admet-2043	684	12	stability	stability	NOUN
admet-2043	684	13	and	and	CCONJ
admet-2043	684	14	circulation	circulation	NOUN
admet-2043	684	15	time	time	NOUN
admet-2043	684	16	,	,	PUNCT
admet-2043	684	17	ultimately	ultimately	ADV
admet-2043	684	18	enabling	enable	VERB
admet-2043	684	19	prolonged	prolonged	ADJ
admet-2043	684	20	drug	drug	NOUN
admet-2043	684	21	delivery	delivery	NOUN
admet-2043	684	22	to	to	ADP
admet-2043	684	23	the	the	DET
admet-2043	684	24	brain	brain	NOUN
admet-2043	684	25	.	.	PUNCT
admet-2043	685	1	coating	coat	VERB
admet-2043	685	2	nanomaterials	nanomaterial	NOUN
admet-2043	685	3	with	with	ADP
admet-2043	685	4	biocompatible	biocompatible	ADJ
admet-2043	685	5	polymers	polymer	NOUN
admet-2043	685	6	like	like	ADP
admet-2043	685	7	polyethyleneimine	polyethyleneimine	PROPN
admet-2043	685	8	(	(	PUNCT
admet-2043	685	9	pei	pei	PROPN
admet-2043	685	10	)	)	PUNCT
admet-2043	685	11	and	and	CCONJ
admet-2043	685	12	chitosan	chitosan	NOUN
admet-2043	685	13	provides	provide	VERB
admet-2043	685	14	a	a	DET
admet-2043	685	15	positive	positive	ADJ
admet-2043	685	16	surface	surface	NOUN
admet-2043	685	17	charge	charge	NOUN
admet-2043	685	18	and	and	CCONJ
admet-2043	685	19	forms	form	VERB
admet-2043	685	20	a	a	DET
admet-2043	685	21	protective	protective	ADJ
admet-2043	685	22	layer	layer	NOUN
admet-2043	685	23	,	,	PUNCT
admet-2043	685	24	enhancing	enhance	VERB
admet-2043	685	25	stability	stability	NOUN
admet-2043	685	26	and	and	CCONJ
admet-2043	685	27	biocompatibility	biocompatibility	NOUN
admet-2043	685	28	while	while	SCONJ
admet-2043	685	29	reducing	reduce	VERB
admet-2043	685	30	cytotoxicity	cytotoxicity	NOUN
admet-2043	685	31	.	.	PUNCT
admet-2043	686	1	ligand	ligand	PROPN
admet-2043	686	2	targeting	targeting	NOUN
admet-2043	686	3	,	,	PUNCT
admet-2043	686	4	achieved	achieve	VERB
admet-2043	686	5	by	by	ADP
admet-2043	686	6	attaching	attach	VERB
admet-2043	686	7	specific	specific	ADJ
admet-2043	686	8	ligands	ligand	NOUN
admet-2043	686	9	to	to	ADP
admet-2043	686	10	nanomaterial	nanomaterial	ADJ
admet-2043	686	11	surfaces	surface	NOUN
admet-2043	686	12	,	,	PUNCT
admet-2043	686	13	enables	enable	VERB
admet-2043	686	14	interaction	interaction	NOUN
admet-2043	686	15	with	with	ADP
admet-2043	686	16	bbb	bbb	NOUN
admet-2043	686	17	receptors	receptor	NOUN
admet-2043	686	18	or	or	CCONJ
admet-2043	686	19	transporters	transporter	NOUN
admet-2043	686	20	,	,	PUNCT
admet-2043	686	21	facilitating	facilitate	VERB
admet-2043	686	22	targeted	target	VERB
admet-2043	686	23	drug	drug	NOUN
admet-2043	686	24	delivery	delivery	NOUN
admet-2043	686	25	and	and	CCONJ
admet-2043	686	26	reducing	reduce	VERB
admet-2043	686	27	off	off	ADP
admet-2043	686	28	-	-	PUNCT
admet-2043	686	29	target	target	NOUN
admet-2043	686	30	effects	effect	NOUN
admet-2043	686	31	.	.	PUNCT
admet-2043	687	1	in	in	ADP
admet-2043	687	2	terms	term	NOUN
admet-2043	687	3	of	of	ADP
admet-2043	687	4	safety	safety	NOUN
admet-2043	687	5	evaluation	evaluation	NOUN
admet-2043	687	6	,	,	PUNCT
admet-2043	687	7	in	in	ADP
admet-2043	687	8	vitro	vitro	X
admet-2043	687	9	assays	assay	NOUN
admet-2043	687	10	and	and	CCONJ
admet-2043	687	11	animal	animal	NOUN
admet-2043	687	12	models	model	NOUN
admet-2043	687	13	are	be	AUX
admet-2043	687	14	crucial	crucial	ADJ
admet-2043	687	15	tools	tool	NOUN
admet-2043	687	16	.	.	PUNCT
admet-2043	688	1	in	in	ADP
admet-2043	688	2	vitro	vitro	X
admet-2043	688	3	assays	assay	NOUN
admet-2043	688	4	assess	assess	VERB
admet-2043	688	5	cytotoxicity	cytotoxicity	NOUN
admet-2043	688	6	,	,	PUNCT
admet-2043	688	7	cellular	cellular	ADJ
admet-2043	688	8	uptake	uptake	NOUN
admet-2043	688	9	,	,	PUNCT
admet-2043	688	10	reactive	reactive	ADJ
admet-2043	688	11	oxygen	oxygen	NOUN
admet-2043	688	12	species	specie	NOUN
admet-2043	688	13	(	(	PUNCT
admet-2043	688	14	ros	ros	PROPN
admet-2043	688	15	)	)	PUNCT
admet-2043	688	16	generation	generation	NOUN
admet-2043	688	17	,	,	PUNCT
admet-2043	688	18	and	and	CCONJ
admet-2043	688	19	bbb	bbb	NOUN
admet-2043	688	20	permeability	permeability	NOUN
admet-2043	688	21	.	.	PUNCT
admet-2043	689	1	animal	animal	NOUN
admet-2043	689	2	models	model	NOUN
admet-2043	689	3	,	,	PUNCT
admet-2043	689	4	particularly	particularly	ADV
admet-2043	689	5	rodents	rodent	NOUN
admet-2043	689	6	,	,	PUNCT
admet-2043	689	7	provide	provide	VERB
admet-2043	689	8	valuable	valuable	ADJ
admet-2043	689	9	insights	insight	NOUN
admet-2043	689	10	into	into	ADP
admet-2043	689	11	acute	acute	ADJ
admet-2043	689	12	and	and	CCONJ
admet-2043	689	13	chronic	chronic	ADJ
admet-2043	689	14	toxicities	toxicity	NOUN
admet-2043	689	15	,	,	PUNCT
admet-2043	689	16	distribution	distribution	NOUN
admet-2043	689	17	patterns	pattern	NOUN
admet-2043	689	18	,	,	PUNCT
admet-2043	689	19	and	and	CCONJ
admet-2043	689	20	long	long	ADJ
admet-2043	689	21	-	-	PUNCT
admet-2043	689	22	term	term	NOUN
admet-2043	689	23	effects	effect	NOUN
admet-2043	689	24	of	of	ADP
admet-2043	689	25	nanomaterials	nanomaterial	NOUN
admet-2043	689	26	.	.	PUNCT
admet-2043	690	1	evaluating	evaluate	VERB
admet-2043	690	2	long	long	ADJ
admet-2043	690	3	-	-	PUNCT
admet-2043	690	4	term	term	NOUN
admet-2043	690	5	effects	effect	NOUN
admet-2043	690	6	,	,	PUNCT
admet-2043	690	7	immunotoxicity	immunotoxicity	NOUN
admet-2043	690	8	,	,	PUNCT
admet-2043	690	9	and	and	CCONJ
admet-2043	690	10	genotoxicity	genotoxicity	NOUN
admet-2043	690	11	is	be	AUX
admet-2043	690	12	crucial	crucial	ADJ
admet-2043	690	13	for	for	ADP
admet-2043	690	14	regulatory	regulatory	ADJ
admet-2043	690	15	approval	approval	NOUN
admet-2043	690	16	,	,	PUNCT
admet-2043	690	17	aligning	align	VERB
admet-2043	690	18	with	with	ADP
admet-2043	690	19	international	international	ADJ
admet-2043	690	20	guidelines	guideline	NOUN
admet-2043	690	21	such	such	ADJ
admet-2043	690	22	as	as	ADP
admet-2043	690	23	those	those	PRON
admet-2043	690	24	from	from	ADP
admet-2043	690	25	the	the	DET
admet-2043	690	26	international	international	ADJ
admet-2043	690	27	council	council	NOUN
admet-2043	690	28	for	for	ADP
admet-2043	690	29	harmonisation	harmonisation	NOUN
admet-2043	690	30	(	(	PUNCT
admet-2043	690	31	ich	ich	NOUN
admet-2043	690	32	)	)	PUNCT
admet-2043	690	33	,	,	PUNCT
admet-2043	690	34	u.s	u.s	PROPN
admet-2043	690	35	.	.	PROPN
admet-2043	690	36	food	food	PROPN
admet-2043	690	37	and	and	CCONJ
admet-2043	690	38	drug	drug	PROPN
admet-2043	690	39	administration	administration	PROPN
admet-2043	690	40	(	(	PUNCT
admet-2043	690	41	fda	fda	PROPN
admet-2043	690	42	)	)	PUNCT
admet-2043	690	43	,	,	PUNCT
admet-2043	690	44	and	and	CCONJ
admet-2043	690	45	european	european	ADJ
admet-2043	690	46	medicines	medicine	NOUN
admet-2043	690	47	agency	agency	NOUN
admet-2043	690	48	(	(	PUNCT
admet-2043	690	49	ema	ema	PROPN
admet-2043	690	50	)	)	PUNCT
admet-2043	690	51	.	.	PUNCT
admet-2043	691	1	admet	admet	PROPN
admet-2043	691	2	&	&	CCONJ
admet-2043	691	3	dmpk	dmpk	PROPN
admet-2043	691	4	12(1	12(1	PROPN
admet-2043	691	5	)	)	PUNCT
admet-2043	691	6	(	(	PUNCT
admet-2043	691	7	2024	2024	NUM
admet-2043	691	8	)	)	PUNCT
admet-2043	691	9	63	63	NUM
admet-2043	691	10	-	-	SYM
admet-2043	691	11	105	105	NUM
admet-2043	691	12	nanomaterials	nanomaterial	NOUN
admet-2043	691	13	as	as	ADP
admet-2043	691	14	drug	drug	NOUN
admet-2043	691	15	delivery	delivery	NOUN
admet-2043	691	16	agents	agent	NOUN
admet-2043	691	17	for	for	ADP
admet-2043	691	18	overcoming	overcome	VERB
admet-2043	691	19	bbb	bbb	PROPN
admet-2043	691	20	doi	doi	NOUN
admet-2043	691	21	:	:	PUNCT
admet-2043	691	22	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	691	23	89	89	NUM
admet-2043	691	24	in	in	ADP
admet-2043	691	25	essence	essence	NOUN
admet-2043	691	26	,	,	PUNCT
admet-2043	691	27	a	a	DET
admet-2043	691	28	comprehensive	comprehensive	ADJ
admet-2043	691	29	understanding	understanding	NOUN
admet-2043	691	30	of	of	ADP
admet-2043	691	31	safety	safety	NOUN
admet-2043	691	32	measures	measure	NOUN
admet-2043	691	33	,	,	PUNCT
admet-2043	691	34	encompassing	encompass	VERB
admet-2043	691	35	rational	rational	ADJ
admet-2043	691	36	design	design	NOUN
admet-2043	691	37	,	,	PUNCT
admet-2043	691	38	surface	surface	NOUN
admet-2043	691	39	modification	modification	NOUN
admet-2043	691	40	,	,	PUNCT
admet-2043	691	41	in	in	ADP
admet-2043	691	42	vitro	vitro	X
admet-2043	691	43	evaluations	evaluation	NOUN
admet-2043	691	44	,	,	PUNCT
admet-2043	691	45	animal	animal	NOUN
admet-2043	691	46	studies	study	NOUN
admet-2043	691	47	,	,	PUNCT
admet-2043	691	48	and	and	CCONJ
admet-2043	691	49	regulatory	regulatory	ADJ
admet-2043	691	50	considerations	consideration	NOUN
admet-2043	691	51	,	,	PUNCT
admet-2043	691	52	is	be	AUX
admet-2043	691	53	imperative	imperative	ADJ
admet-2043	691	54	for	for	ADP
admet-2043	691	55	the	the	DET
admet-2043	691	56	successful	successful	ADJ
admet-2043	691	57	and	and	CCONJ
admet-2043	691	58	safe	safe	ADJ
admet-2043	691	59	translation	translation	NOUN
admet-2043	691	60	of	of	ADP
admet-2043	691	61	nanomaterial	nanomaterial	NOUN
admet-2043	691	62	-	-	PUNCT
admet-2043	691	63	based	base	VERB
admet-2043	691	64	drug	drug	NOUN
admet-2043	691	65	delivery	delivery	NOUN
admet-2043	691	66	systems	system	NOUN
admet-2043	691	67	for	for	ADP
admet-2043	691	68	treating	treat	VERB
admet-2043	691	69	brain	brain	NOUN
admet-2043	691	70	disorders	disorder	NOUN
admet-2043	691	71	.	.	PUNCT
admet-2043	692	1	these	these	DET
admet-2043	692	2	safety	safety	NOUN
admet-2043	692	3	measures	measure	NOUN
admet-2043	692	4	are	be	AUX
admet-2043	692	5	essential	essential	ADJ
admet-2043	692	6	to	to	PART
admet-2043	692	7	advance	advance	VERB
admet-2043	692	8	nanomaterial	nanomaterial	NOUN
admet-2043	692	9	-	-	PUNCT
admet-2043	692	10	based	base	VERB
admet-2043	692	11	therapies	therapy	NOUN
admet-2043	692	12	and	and	CCONJ
admet-2043	692	13	enhance	enhance	VERB
admet-2043	692	14	their	their	PRON
admet-2043	692	15	potential	potential	NOUN
admet-2043	692	16	to	to	PART
admet-2043	692	17	revolutionize	revolutionize	VERB
admet-2043	692	18	the	the	DET
admet-2043	692	19	treatment	treatment	NOUN
admet-2043	692	20	of	of	ADP
admet-2043	692	21	neurological	neurological	ADJ
admet-2043	692	22	conditions	condition	NOUN
admet-2043	692	23	while	while	SCONJ
admet-2043	692	24	ensuring	ensure	VERB
admet-2043	692	25	patient	patient	ADJ
admet-2043	692	26	safety	safety	NOUN
admet-2043	692	27	and	and	CCONJ
admet-2043	692	28	well	well	ADV
admet-2043	692	29	-	-	PUNCT
admet-2043	692	30	being	being	NOUN
admet-2043	692	31	.	.	PUNCT
admet-2043	693	1	applications	application	NOUN
admet-2043	693	2	of	of	ADP
admet-2043	693	3	nanomaterials	nanomaterial	NOUN
admet-2043	693	4	in	in	ADP
admet-2043	693	5	delivering	deliver	VERB
admet-2043	693	6	drugs	drug	NOUN
admet-2043	693	7	across	across	ADP
admet-2043	693	8	bbb	bbb	NOUN
admet-2043	693	9	nanomaterials	nanomaterial	NOUN
admet-2043	693	10	,	,	PUNCT
admet-2043	693	11	such	such	ADJ
admet-2043	693	12	as	as	ADP
admet-2043	693	13	micelles	micelle	NOUN
admet-2043	693	14	and	and	CCONJ
admet-2043	693	15	liposomes	liposome	NOUN
admet-2043	693	16	,	,	PUNCT
admet-2043	693	17	have	have	AUX
admet-2043	693	18	emerged	emerge	VERB
admet-2043	693	19	as	as	ADP
admet-2043	693	20	promising	promising	ADJ
admet-2043	693	21	tools	tool	NOUN
admet-2043	693	22	in	in	ADP
admet-2043	693	23	cancer	cancer	NOUN
admet-2043	693	24	therapy	therapy	NOUN
admet-2043	693	25	,	,	PUNCT
admet-2043	693	26	offering	offer	VERB
admet-2043	693	27	several	several	ADJ
admet-2043	693	28	advantages	advantage	NOUN
admet-2043	693	29	for	for	ADP
admet-2043	693	30	the	the	DET
admet-2043	693	31	delivery	delivery	NOUN
admet-2043	693	32	of	of	ADP
admet-2043	693	33	chemotherapeutic	chemotherapeutic	ADJ
admet-2043	693	34	agents	agent	NOUN
admet-2043	693	35	.	.	PUNCT
admet-2043	694	1	these	these	DET
admet-2043	694	2	nanocarriers	nanocarrier	NOUN
admet-2043	694	3	possess	possess	VERB
admet-2043	694	4	a	a	DET
admet-2043	694	5	hydrophobic	hydrophobic	NOUN
admet-2043	694	6	core	core	NOUN
admet-2043	694	7	and	and	CCONJ
admet-2043	694	8	a	a	DET
admet-2043	694	9	hydrophilic	hydrophilic	ADJ
admet-2043	694	10	shell	shell	NOUN
admet-2043	694	11	,	,	PUNCT
admet-2043	694	12	enabling	enable	VERB
admet-2043	694	13	them	they	PRON
admet-2043	694	14	to	to	PART
admet-2043	694	15	solubilize	solubilize	VERB
admet-2043	694	16	insoluble	insoluble	ADJ
admet-2043	694	17	drugs	drug	NOUN
admet-2043	694	18	.	.	PUNCT
admet-2043	695	1	by	by	ADP
admet-2043	695	2	modifying	modify	VERB
admet-2043	695	3	the	the	DET
admet-2043	695	4	surface	surface	NOUN
admet-2043	695	5	of	of	ADP
admet-2043	695	6	nanocarriers	nanocarrier	NOUN
admet-2043	695	7	,	,	PUNCT
admet-2043	695	8	such	such	ADJ
admet-2043	695	9	as	as	ADP
admet-2043	695	10	through	through	ADP
admet-2043	695	11	pegylation	pegylation	NOUN
admet-2043	695	12	,	,	PUNCT
admet-2043	695	13	they	they	PRON
admet-2043	695	14	can	can	AUX
admet-2043	695	15	passively	passively	ADV
admet-2043	695	16	target	target	VERB
admet-2043	695	17	tumours	tumour	NOUN
admet-2043	695	18	and	and	CCONJ
admet-2043	695	19	inflamed	inflame	VERB
admet-2043	695	20	tissues	tissue	NOUN
admet-2043	695	21	by	by	ADP
admet-2043	695	22	exploiting	exploit	VERB
admet-2043	695	23	fenestrated	fenestrated	ADJ
admet-2043	695	24	vasculature	vasculature	NOUN
admet-2043	695	25	,	,	PUNCT
admet-2043	695	26	resulting	result	VERB
admet-2043	695	27	in	in	ADP
admet-2043	695	28	higher	high	ADJ
admet-2043	695	29	drug	drug	NOUN
admet-2043	695	30	concentrations	concentration	NOUN
admet-2043	695	31	at	at	ADP
admet-2043	695	32	the	the	DET
admet-2043	695	33	tumor	tumor	NOUN
admet-2043	695	34	site	site	NOUN
admet-2043	695	35	[	[	X
admet-2043	695	36	194	194	NUM
admet-2043	695	37	]	]	PUNCT
admet-2043	695	38	.	.	PUNCT
admet-2043	696	1	notably	notably	ADV
admet-2043	696	2	,	,	PUNCT
admet-2043	696	3	clinical	clinical	ADJ
admet-2043	696	4	studies	study	NOUN
admet-2043	696	5	for	for	ADP
admet-2043	696	6	a	a	DET
admet-2043	696	7	number	number	NOUN
admet-2043	696	8	of	of	ADP
admet-2043	696	9	polymeric	polymeric	ADJ
admet-2043	696	10	micelles	micelle	NOUN
admet-2043	696	11	carrying	carry	VERB
admet-2043	696	12	anticancer	anticancer	NOUN
admet-2043	696	13	medications	medication	NOUN
admet-2043	696	14	,	,	PUNCT
admet-2043	696	15	such	such	ADJ
admet-2043	696	16	as	as	ADP
admet-2043	696	17	nk012	nk012	PROPN
admet-2043	696	18	,	,	PUNCT
admet-2043	696	19	nk105	nk105	PROPN
admet-2043	696	20	,	,	PUNCT
admet-2043	696	21	nk911	nk911	PROPN
admet-2043	696	22	,	,	PUNCT
admet-2043	696	23	nc-6004	nc-6004	NOUN
admet-2043	696	24	,	,	PUNCT
admet-2043	696	25	and	and	CCONJ
admet-2043	696	26	sp1049c	sp1049c	PROPN
admet-2043	696	27	,	,	PUNCT
admet-2043	696	28	are	be	AUX
admet-2043	696	29	now	now	ADV
admet-2043	696	30	being	be	AUX
admet-2043	696	31	conducted	conduct	VERB
admet-2043	696	32	[	[	PUNCT
admet-2043	696	33	195	195	NUM
admet-2043	696	34	]	]	PUNCT
admet-2043	696	35	.	.	PUNCT
admet-2043	697	1	one	one	NUM
admet-2043	697	2	successful	successful	ADJ
admet-2043	697	3	example	example	NOUN
admet-2043	697	4	is	be	AUX
admet-2043	697	5	genexol	genexol	NOUN
admet-2043	697	6	-	-	PUNCT
admet-2043	697	7	pm	pm	NOUN
admet-2043	697	8	,	,	PUNCT
admet-2043	697	9	a	a	DET
admet-2043	697	10	paclitaxel	paclitaxel	NOUN
admet-2043	697	11	-	-	PUNCT
admet-2043	697	12	loaded	load	VERB
admet-2043	697	13	polymeric	polymeric	ADJ
admet-2043	697	14	micelle	micelle	NOUN
admet-2043	697	15	formulation	formulation	NOUN
admet-2043	697	16	approved	approve	VERB
admet-2043	697	17	for	for	ADP
admet-2043	697	18	breast	breast	NOUN
admet-2043	697	19	cancer	cancer	NOUN
admet-2043	697	20	treatment	treatment	NOUN
admet-2043	697	21	[	[	X
admet-2043	697	22	196	196	NUM
admet-2043	697	23	]	]	PUNCT
admet-2043	697	24	.	.	PUNCT
admet-2043	698	1	another	another	DET
admet-2043	698	2	class	class	NOUN
admet-2043	698	3	of	of	ADP
admet-2043	698	4	nms	nms	PROPN
admet-2043	698	5	,	,	PUNCT
admet-2043	698	6	dendrimers	dendrimer	NOUN
admet-2043	698	7	,	,	PUNCT
admet-2043	698	8	has	have	AUX
admet-2043	698	9	demonstrated	demonstrate	VERB
admet-2043	698	10	great	great	ADJ
admet-2043	698	11	potential	potential	NOUN
admet-2043	698	12	in	in	ADP
admet-2043	698	13	localizing	localize	VERB
admet-2043	698	14	,	,	PUNCT
admet-2043	698	15	imaging	imaging	NOUN
admet-2043	698	16	and	and	CCONJ
admet-2043	698	17	delivering	deliver	VERB
admet-2043	698	18	anticancer	anticancer	NOUN
admet-2043	698	19	drugs	drug	NOUN
admet-2043	698	20	[	[	X
admet-2043	698	21	197	197	NUM
admet-2043	698	22	]	]	PUNCT
admet-2043	698	23	.	.	PUNCT
admet-2043	699	1	these	these	DET
admet-2043	699	2	highly	highly	ADV
admet-2043	699	3	branched	branched	ADJ
admet-2043	699	4	macromolecules	macromolecule	NOUN
admet-2043	699	5	can	can	AUX
admet-2043	699	6	be	be	AUX
admet-2043	699	7	functionalized	functionalize	VERB
admet-2043	699	8	with	with	ADP
admet-2043	699	9	various	various	ADJ
admet-2043	699	10	ligands	ligand	NOUN
admet-2043	699	11	for	for	ADP
admet-2043	699	12	targeted	target	VERB
admet-2043	699	13	drug	drug	NOUN
admet-2043	699	14	delivery	delivery	NOUN
admet-2043	699	15	[	[	X
admet-2043	699	16	198	198	NUM
admet-2043	699	17	]	]	PUNCT
admet-2043	699	18	.	.	PUNCT
admet-2043	700	1	for	for	ADP
admet-2043	700	2	instance	instance	NOUN
admet-2043	700	3	,	,	PUNCT
admet-2043	700	4	a	a	DET
admet-2043	700	5	polyfunctional	polyfunctional	ADJ
admet-2043	700	6	dendrimer	dendrimer	NOUN
admet-2043	700	7	system	system	NOUN
admet-2043	700	8	with	with	ADP
admet-2043	700	9	folic	folic	ADJ
admet-2043	700	10	acid	acid	NOUN
admet-2043	700	11	as	as	ADP
admet-2043	700	12	the	the	DET
admet-2043	700	13	targeting	targeting	NOUN
admet-2043	700	14	ligand	ligand	NOUN
admet-2043	700	15	,	,	PUNCT
admet-2043	700	16	fluorescein	fluorescein	NOUN
admet-2043	700	17	for	for	ADP
admet-2043	700	18	imaging	imaging	NOUN
admet-2043	700	19	,	,	PUNCT
admet-2043	700	20	and	and	CCONJ
admet-2043	700	21	methotrexate	methotrexate	VERB
admet-2043	700	22	as	as	SCONJ
admet-2043	700	23	the	the	DET
admet-2043	700	24	anticancer	anticancer	NOUN
admet-2043	700	25	drug	drug	NOUN
admet-2043	700	26	have	have	AUX
admet-2043	700	27	shown	show	VERB
admet-2043	700	28	successful	successful	ADJ
admet-2043	700	29	results	result	NOUN
admet-2043	700	30	in	in	ADP
admet-2043	700	31	vitro	vitro	X
admet-2043	700	32	[	[	X
admet-2043	700	33	197	197	NUM
admet-2043	700	34	]	]	PUNCT
admet-2043	700	35	.	.	PUNCT
admet-2043	701	1	carbon	carbon	NOUN
admet-2043	701	2	nanotubes	nanotube	NOUN
admet-2043	701	3	offer	offer	VERB
admet-2043	701	4	unique	unique	ADJ
admet-2043	701	5	advantages	advantage	NOUN
admet-2043	701	6	in	in	ADP
admet-2043	701	7	cancer	cancer	NOUN
admet-2043	701	8	treatment	treatment	NOUN
admet-2043	701	9	with	with	ADP
admet-2043	701	10	their	their	PRON
admet-2043	701	11	large	large	ADJ
admet-2043	701	12	surface	surface	NOUN
admet-2043	701	13	area	area	NOUN
admet-2043	701	14	and	and	CCONJ
admet-2043	701	15	capability	capability	NOUN
admet-2043	701	16	to	to	PART
admet-2043	701	17	load	load	VERB
admet-2043	701	18	hydrophobic	hydrophobic	NOUN
admet-2043	701	19	drugs	drug	NOUN
admet-2043	701	20	.	.	PUNCT
admet-2043	702	1	they	they	PRON
admet-2043	702	2	can	can	AUX
admet-2043	702	3	easily	easily	ADV
admet-2043	702	4	encapsulate	encapsulate	VERB
admet-2043	702	5	water	water	NOUN
admet-2043	702	6	-	-	PUNCT
admet-2043	702	7	insoluble	insoluble	ADJ
admet-2043	702	8	drugs	drug	NOUN
admet-2043	702	9	within	within	ADP
admet-2043	702	10	their	their	PRON
admet-2043	702	11	hydrophobic	hydrophobic	NOUN
admet-2043	702	12	hollow	hollow	ADJ
admet-2043	702	13	interior	interior	NOUN
admet-2043	702	14	.	.	PUNCT
admet-2043	703	1	moreover	moreover	ADV
admet-2043	703	2	,	,	PUNCT
admet-2043	703	3	the	the	DET
admet-2043	703	4	outer	outer	ADJ
admet-2043	703	5	surface	surface	NOUN
admet-2043	703	6	of	of	ADP
admet-2043	703	7	carbon	carbon	NOUN
admet-2043	703	8	nanotubes	nanotube	NOUN
admet-2043	703	9	can	can	AUX
admet-2043	703	10	be	be	AUX
admet-2043	703	11	functionalized	functionalize	VERB
admet-2043	703	12	to	to	PART
admet-2043	703	13	specifically	specifically	ADV
admet-2043	703	14	target	target	VERB
admet-2043	703	15	cancer	cancer	NOUN
admet-2043	703	16	receptors	receptor	NOUN
admet-2043	703	17	or	or	CCONJ
admet-2043	703	18	serve	serve	VERB
admet-2043	703	19	as	as	ADP
admet-2043	703	20	contrast	contrast	NOUN
admet-2043	703	21	agents	agent	NOUN
admet-2043	703	22	for	for	ADP
admet-2043	703	23	imaging	image	VERB
admet-2043	703	24	purposes	purpose	NOUN
admet-2043	703	25	[	[	X
admet-2043	703	26	199	199	NUM
admet-2043	703	27	]	]	PUNCT
admet-2043	703	28	.	.	PUNCT
admet-2043	704	1	similarly	similarly	ADV
admet-2043	704	2	,	,	PUNCT
admet-2043	704	3	buckminsterfullerene	buckminsterfullerene	NOUN
admet-2043	704	4	c60	c60	NOUN
admet-2043	704	5	,	,	PUNCT
admet-2043	704	6	a	a	DET
admet-2043	704	7	spherical	spherical	ADJ
admet-2043	704	8	molecule	molecule	NOUN
admet-2043	704	9	,	,	PUNCT
admet-2043	704	10	and	and	CCONJ
admet-2043	704	11	its	its	PRON
admet-2043	704	12	derivatives	derivative	NOUN
admet-2043	704	13	are	be	AUX
admet-2043	704	14	being	be	AUX
admet-2043	704	15	evaluated	evaluate	VERB
admet-2043	704	16	for	for	ADP
admet-2043	704	17	their	their	PRON
admet-2043	704	18	potential	potential	NOUN
admet-2043	704	19	in	in	ADP
admet-2043	704	20	cancer	cancer	NOUN
admet-2043	704	21	therapy	therapy	NOUN
admet-2043	704	22	[	[	X
admet-2043	704	23	200	200	NUM
admet-2043	704	24	]	]	PUNCT
admet-2043	704	25	.	.	PUNCT
admet-2043	705	1	in	in	ADP
admet-2043	705	2	the	the	DET
admet-2043	705	3	field	field	NOUN
admet-2043	705	4	of	of	ADP
admet-2043	705	5	diagnosis	diagnosis	NOUN
admet-2043	705	6	,	,	PUNCT
admet-2043	705	7	quantum	quantum	NOUN
admet-2043	705	8	dots	dot	NOUN
admet-2043	705	9	present	present	VERB
admet-2043	705	10	significant	significant	ADJ
admet-2043	705	11	advantages	advantage	NOUN
admet-2043	705	12	for	for	ADP
admet-2043	705	13	monitoring	monitor	VERB
admet-2043	705	14	various	various	ADJ
admet-2043	705	15	biological	biological	ADJ
admet-2043	705	16	events	event	NOUN
admet-2043	705	17	simultaneously	simultaneously	ADV
admet-2043	705	18	.	.	PUNCT
admet-2043	706	1	these	these	DET
admet-2043	706	2	fluorescent	fluorescent	ADJ
admet-2043	706	3	nanoparticles	nanoparticle	NOUN
admet-2043	706	4	can	can	AUX
admet-2043	706	5	be	be	AUX
admet-2043	706	6	excited	excite	VERB
admet-2043	706	7	using	use	VERB
admet-2043	706	8	white	white	ADJ
admet-2043	706	9	light	light	NOUN
admet-2043	706	10	and	and	CCONJ
admet-2043	706	11	conjugated	conjugate	VERB
admet-2043	706	12	with	with	ADP
admet-2043	706	13	biomolecules	biomolecule	NOUN
admet-2043	706	14	,	,	PUNCT
admet-2043	706	15	allowing	allow	VERB
admet-2043	706	16	for	for	ADP
admet-2043	706	17	long	long	ADJ
admet-2043	706	18	-	-	PUNCT
admet-2043	706	19	term	term	NOUN
admet-2043	706	20	tracking	tracking	NOUN
admet-2043	706	21	and	and	CCONJ
admet-2043	706	22	probing	probe	VERB
admet-2043	706	23	of	of	ADP
admet-2043	706	24	different	different	ADJ
admet-2043	706	25	bio	bio	NOUN
admet-2043	706	26	-	-	NOUN
admet-2043	706	27	mechanisms	mechanism	NOUN
admet-2043	706	28	.	.	PUNCT
admet-2043	707	1	this	this	DET
admet-2043	707	2	technology	technology	NOUN
admet-2043	707	3	enables	enable	VERB
admet-2043	707	4	tagging	tag	VERB
admet-2043	707	5	multiple	multiple	ADJ
admet-2043	707	6	biological	biological	ADJ
admet-2043	707	7	molecules	molecule	NOUN
admet-2043	707	8	with	with	ADP
admet-2043	707	9	nanodots	nanodot	NOUN
admet-2043	707	10	of	of	ADP
admet-2043	707	11	specific	specific	ADJ
admet-2043	707	12	colours	colour	NOUN
admet-2043	707	13	[	[	X
admet-2043	707	14	201	201	NUM
admet-2043	707	15	]	]	PUNCT
admet-2043	707	16	.	.	PUNCT
admet-2043	708	1	theranostic	theranostic	ADJ
admet-2043	708	2	nms	nms	NOUN
admet-2043	708	3	,	,	PUNCT
admet-2043	708	4	which	which	PRON
admet-2043	708	5	combine	combine	VERB
admet-2043	708	6	medication	medication	NOUN
admet-2043	708	7	and	and	CCONJ
admet-2043	708	8	an	an	DET
admet-2043	708	9	imaging	imaging	NOUN
admet-2043	708	10	agent	agent	NOUN
admet-2043	708	11	in	in	ADP
admet-2043	708	12	a	a	DET
admet-2043	708	13	single	single	ADJ
admet-2043	708	14	formulation	formulation	NOUN
admet-2043	708	15	,	,	PUNCT
admet-2043	708	16	have	have	AUX
admet-2043	708	17	also	also	ADV
admet-2043	708	18	attracted	attract	VERB
admet-2043	708	19	much	much	ADJ
admet-2043	708	20	attention	attention	NOUN
admet-2043	708	21	.	.	PUNCT
admet-2043	709	1	drug	drug	NOUN
admet-2043	709	2	conjugates	conjugate	NOUN
admet-2043	709	3	,	,	PUNCT
admet-2043	709	4	dendrimers	dendrimer	NOUN
admet-2043	709	5	,	,	PUNCT
admet-2043	709	6	micelles	micelle	NOUN
admet-2043	709	7	,	,	PUNCT
admet-2043	709	8	vesicles	vesicle	NOUN
admet-2043	709	9	,	,	PUNCT
admet-2043	709	10	core	core	NOUN
admet-2043	709	11	-	-	PUNCT
admet-2043	709	12	shell	shell	NOUN
admet-2043	709	13	particles	particle	NOUN
admet-2043	709	14	,	,	PUNCT
admet-2043	709	15	and	and	CCONJ
admet-2043	709	16	carbon	carbon	NOUN
admet-2043	709	17	nanotubes	nanotube	NOUN
admet-2043	709	18	are	be	AUX
admet-2043	709	19	just	just	ADV
admet-2043	709	20	a	a	DET
admet-2043	709	21	few	few	ADJ
admet-2043	709	22	examples	example	NOUN
admet-2043	709	23	of	of	ADP
admet-2043	709	24	the	the	DET
admet-2043	709	25	various	various	ADJ
admet-2043	709	26	types	type	NOUN
admet-2043	709	27	of	of	ADP
admet-2043	709	28	nms	nms	PROPN
admet-2043	709	29	that	that	PRON
admet-2043	709	30	have	have	AUX
admet-2043	709	31	been	be	AUX
admet-2043	709	32	investigated	investigate	VERB
admet-2043	709	33	for	for	ADP
admet-2043	709	34	tracking	tracking	NOUN
admet-2043	709	35	nanoparticle	nanoparticle	NOUN
admet-2043	709	36	routes	route	NOUN
admet-2043	709	37	,	,	PUNCT
admet-2043	709	38	locating	locate	VERB
admet-2043	709	39	at	at	ADP
admet-2043	709	40	the	the	DET
admet-2043	709	41	target	target	NOUN
admet-2043	709	42	location	location	NOUN
admet-2043	709	43	,	,	PUNCT
admet-2043	709	44	and	and	CCONJ
admet-2043	709	45	evaluating	evaluate	VERB
admet-2043	709	46	therapeutic	therapeutic	ADJ
admet-2043	709	47	response	response	NOUN
admet-2043	710	1	[	[	X
admet-2043	710	2	202	202	NUM
admet-2043	710	3	]	]	PUNCT
admet-2043	710	4	.	.	PUNCT
admet-2043	711	1	nanotechnology	nanotechnology	PROPN
admet-2043	711	2	has	have	AUX
admet-2043	711	3	also	also	ADV
admet-2043	711	4	made	make	VERB
admet-2043	711	5	significant	significant	ADJ
admet-2043	711	6	contributions	contribution	NOUN
admet-2043	711	7	to	to	ADP
admet-2043	711	8	the	the	DET
admet-2043	711	9	treatment	treatment	NOUN
admet-2043	711	10	of	of	ADP
admet-2043	711	11	hiv	hiv	PROPN
admet-2043	711	12	and	and	CCONJ
admet-2043	711	13	aids	aids	PROPN
admet-2043	711	14	.	.	PUNCT
admet-2043	712	1	polymeric	polymeric	ADJ
admet-2043	712	2	nms	nms	NOUN
admet-2043	712	3	have	have	AUX
admet-2043	712	4	been	be	AUX
admet-2043	712	5	developed	develop	VERB
admet-2043	712	6	to	to	PART
admet-2043	712	7	deliver	deliver	VERB
admet-2043	712	8	antiretroviral	antiretroviral	ADJ
admet-2043	712	9	(	(	PUNCT
admet-2043	712	10	arv	arv	NOUN
admet-2043	712	11	)	)	PUNCT
admet-2043	712	12	drugs	drug	NOUN
admet-2043	712	13	intracellularly	intracellularly	ADV
admet-2043	712	14	,	,	PUNCT
admet-2043	712	15	including	include	VERB
admet-2043	712	16	to	to	ADP
admet-2043	712	17	the	the	DET
admet-2043	712	18	brain	brain	NOUN
admet-2043	712	19	,	,	PUNCT
admet-2043	712	20	enhancing	enhance	VERB
admet-2043	712	21	the	the	DET
admet-2043	712	22	effectiveness	effectiveness	NOUN
admet-2043	712	23	of	of	ADP
admet-2043	712	24	treatment	treatment	NOUN
admet-2043	712	25	.	.	PUNCT
admet-2043	713	1	these	these	DET
admet-2043	713	2	nms	nms	NOUN
admet-2043	713	3	can	can	AUX
admet-2043	713	4	overcome	overcome	VERB
admet-2043	713	5	barriers	barrier	NOUN
admet-2043	713	6	such	such	ADJ
admet-2043	713	7	as	as	ADP
admet-2043	713	8	the	the	DET
admet-2043	713	9	mucosal	mucosal	ADJ
admet-2043	713	10	epithelial	epithelial	ADJ
admet-2043	713	11	barrier	barrier	NOUN
admet-2043	713	12	and	and	CCONJ
admet-2043	713	13	the	the	DET
admet-2043	713	14	bbb	bbb	PROPN
admet-2043	713	15	,	,	PUNCT
admet-2043	713	16	enabling	enable	VERB
admet-2043	713	17	successful	successful	ADJ
admet-2043	713	18	delivery	delivery	NOUN
admet-2043	713	19	of	of	ADP
admet-2043	713	20	anti	anti	ADJ
admet-2043	713	21	-	-	ADJ
admet-2043	713	22	hiv	hiv	ADJ
admet-2043	713	23	medications	medication	NOUN
admet-2043	713	24	.	.	PUNCT
admet-2043	714	1	combining	combine	VERB
admet-2043	714	2	nanotechnology	nanotechnology	NOUN
admet-2043	714	3	with	with	ADP
admet-2043	714	4	vaccinations	vaccination	NOUN
admet-2043	714	5	offers	offer	VERB
admet-2043	714	6	a	a	DET
admet-2043	714	7	potential	potential	ADJ
admet-2043	714	8	strategy	strategy	NOUN
admet-2043	714	9	to	to	PART
admet-2043	714	10	prevent	prevent	VERB
admet-2043	714	11	hiv	hiv	PROPN
admet-2043	714	12	infections	infection	NOUN
admet-2043	714	13	[	[	X
admet-2043	714	14	203	203	NUM
admet-2043	714	15	]	]	PUNCT
admet-2043	714	16	.	.	PUNCT
admet-2043	715	1	in	in	ADP
admet-2043	715	2	nutraceutical	nutraceutical	ADJ
admet-2043	715	3	delivery	delivery	NOUN
admet-2043	715	4	,	,	PUNCT
admet-2043	715	5	nanotechnology	nanotechnology	NOUN
admet-2043	715	6	has	have	AUX
admet-2043	715	7	played	play	VERB
admet-2043	715	8	a	a	DET
admet-2043	715	9	vital	vital	ADJ
admet-2043	715	10	role	role	NOUN
admet-2043	715	11	in	in	ADP
admet-2043	715	12	improving	improve	VERB
admet-2043	715	13	the	the	DET
admet-2043	715	14	bioavailability	bioavailability	NOUN
admet-2043	715	15	and	and	CCONJ
admet-2043	715	16	efficacy	efficacy	NOUN
admet-2043	715	17	of	of	ADP
admet-2043	715	18	orally	orally	ADV
admet-2043	715	19	consumed	consume	VERB
admet-2043	715	20	nutraceuticals	nutraceutical	NOUN
admet-2043	715	21	.	.	PUNCT
admet-2043	716	1	nanoparticle	nanoparticle	NOUN
admet-2043	716	2	formulations	formulation	NOUN
admet-2043	716	3	have	have	AUX
admet-2043	716	4	been	be	AUX
admet-2043	716	5	investigated	investigate	VERB
admet-2043	716	6	to	to	PART
admet-2043	716	7	enhance	enhance	VERB
admet-2043	716	8	the	the	DET
admet-2043	716	9	dissolution	dissolution	NOUN
admet-2043	716	10	mechanisms	mechanism	NOUN
admet-2043	716	11	of	of	ADP
admet-2043	716	12	lipophilic	lipophilic	ADJ
admet-2043	716	13	nutraceuticals	nutraceutical	NOUN
admet-2043	716	14	,	,	PUNCT
admet-2043	716	15	such	such	ADJ
admet-2043	716	16	as	as	ADP
admet-2043	716	17	fat	fat	ADJ
admet-2043	716	18	-	-	PUNCT
admet-2043	716	19	soluble	soluble	ADJ
admet-2043	716	20	vitamins	vitamin	NOUN
admet-2043	716	21	(	(	PUNCT
admet-2043	716	22	a	a	DET
admet-2043	716	23	,	,	PUNCT
admet-2043	716	24	d	d	NOUN
admet-2043	716	25	,	,	PUNCT
admet-2043	716	26	e	e	NOUN
admet-2043	716	27	,	,	PUNCT
admet-2043	716	28	and	and	CCONJ
admet-2043	716	29	k	k	NOUN
admet-2043	716	30	)	)	PUNCT
admet-2043	716	31	and	and	CCONJ
admet-2043	716	32	polyunsaturated	polyunsaturated	ADJ
admet-2043	716	33	lipids	lipid	NOUN
admet-2043	716	34	.	.	PUNCT
admet-2043	717	1	these	these	DET
admet-2043	717	2	formulations	formulation	NOUN
admet-2043	717	3	improve	improve	VERB
admet-2043	717	4	the	the	DET
admet-2043	717	5	effectiveness	effectiveness	NOUN
admet-2043	717	6	of	of	ADP
admet-2043	717	7	nutraceuticals	nutraceutical	NOUN
admet-2043	717	8	and	and	CCONJ
admet-2043	717	9	provide	provide	VERB
admet-2043	717	10	additional	additional	ADJ
admet-2043	717	11	health	health	NOUN
admet-2043	717	12	benefits	benefit	NOUN
admet-2043	717	13	,	,	PUNCT
admet-2043	717	14	reducing	reduce	VERB
admet-2043	717	15	the	the	DET
admet-2043	717	16	risk	risk	NOUN
admet-2043	717	17	of	of	ADP
admet-2043	717	18	chronic	chronic	ADJ
admet-2043	717	19	illnesses	illness	NOUN
admet-2043	717	20	[	[	X
admet-2043	717	21	204	204	NUM
admet-2043	717	22	,	,	PUNCT
admet-2043	717	23	205	205	NUM
admet-2043	717	24	]	]	PUNCT
admet-2043	717	25	.	.	PUNCT
admet-2043	718	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	718	2	m.	m.	NOUN
admet-2043	718	3	kulkarni	kulkarni	PROPN
admet-2043	718	4	et	et	PROPN
admet-2043	718	5	al	al	PROPN
admet-2043	718	6	.	.	PROPN
admet-2043	718	7	admet	admet	PROPN
admet-2043	718	8	&	&	CCONJ
admet-2043	718	9	dmpk	dmpk	PROPN
admet-2043	718	10	12(1	12(1	PROPN
admet-2043	718	11	)	)	PUNCT
admet-2043	718	12	(	(	PUNCT
admet-2043	718	13	2024	2024	NUM
admet-2043	718	14	)	)	PUNCT
admet-2043	718	15	63	63	NUM
admet-2043	718	16	-	-	SYM
admet-2043	718	17	105	105	NUM
admet-2043	718	18	90	90	NUM
admet-2043	718	19	future	future	ADJ
admet-2043	718	20	prospects	prospect	NOUN
admet-2043	718	21	of	of	ADP
admet-2043	718	22	nanomaterials	nanomaterial	NOUN
admet-2043	718	23	the	the	DET
admet-2043	718	24	field	field	NOUN
admet-2043	718	25	of	of	ADP
admet-2043	718	26	nanomedicine	nanomedicine	NOUN
admet-2043	718	27	is	be	AUX
admet-2043	718	28	currently	currently	ADV
admet-2043	718	29	a	a	DET
admet-2043	718	30	highly	highly	ADV
admet-2043	718	31	captivating	captivating	ADJ
admet-2043	718	32	area	area	NOUN
admet-2043	718	33	of	of	ADP
admet-2043	718	34	research	research	NOUN
admet-2043	718	35	,	,	PUNCT
admet-2043	718	36	offering	offer	VERB
admet-2043	718	37	promising	promising	ADJ
admet-2043	718	38	prospects	prospect	NOUN
admet-2043	718	39	for	for	ADP
admet-2043	718	40	disease	disease	NOUN
admet-2043	718	41	diagnosis	diagnosis	NOUN
admet-2043	718	42	and	and	CCONJ
admet-2043	718	43	combined	combined	ADJ
admet-2043	718	44	diagnosis	diagnosis	NOUN
admet-2043	718	45	-	-	PUNCT
admet-2043	718	46	therapy	therapy	NOUN
admet-2043	718	47	approaches	approach	NOUN
admet-2043	718	48	.	.	PUNCT
admet-2043	719	1	several	several	ADJ
admet-2043	719	2	key	key	ADJ
admet-2043	719	3	aspects	aspect	NOUN
admet-2043	719	4	require	require	VERB
admet-2043	719	5	thorough	thorough	ADJ
admet-2043	719	6	investigation	investigation	NOUN
admet-2043	719	7	and	and	CCONJ
admet-2043	719	8	development	development	NOUN
admet-2043	719	9	.	.	PUNCT
admet-2043	720	1	firstly	firstly	ADV
admet-2043	720	2	,	,	PUNCT
admet-2043	720	3	detailed	detailed	ADJ
admet-2043	720	4	tracing	tracing	NOUN
admet-2043	720	5	and	and	CCONJ
admet-2043	720	6	analysis	analysis	NOUN
admet-2043	720	7	of	of	ADP
admet-2043	720	8	nano	nano	NOUN
admet-2043	720	9	-	-	PUNCT
admet-2043	720	10	based	base	VERB
admet-2043	720	11	drug	drug	NOUN
admet-2043	720	12	delivery	delivery	NOUN
admet-2043	720	13	systems	system	NOUN
admet-2043	720	14	(	(	PUNCT
admet-2043	720	15	nddss	nddss	NOUN
admet-2043	720	16	)	)	PUNCT
admet-2043	720	17	are	be	AUX
admet-2043	720	18	necessary	necessary	ADJ
admet-2043	720	19	to	to	PART
admet-2043	720	20	understand	understand	VERB
admet-2043	720	21	their	their	PRON
admet-2043	720	22	integrity	integrity	NOUN
admet-2043	720	23	,	,	PUNCT
admet-2043	720	24	surface	surface	NOUN
admet-2043	720	25	characteristics	characteristic	NOUN
admet-2043	720	26	,	,	PUNCT
admet-2043	720	27	pharmacokinetics	pharmacokinetic	NOUN
admet-2043	720	28	,	,	PUNCT
admet-2043	720	29	biodistribution	biodistribution	NOUN
admet-2043	720	30	,	,	PUNCT
admet-2043	720	31	and	and	CCONJ
admet-2043	720	32	immunological	immunological	ADJ
admet-2043	720	33	effects	effect	NOUN
admet-2043	720	34	[	[	X
admet-2043	720	35	206	206	NUM
admet-2043	720	36	-	-	SYM
admet-2043	720	37	208	208	NUM
admet-2043	720	38	]	]	PUNCT
admet-2043	720	39	.	.	PUNCT
admet-2043	721	1	advanced	advanced	ADJ
admet-2043	721	2	technologies	technology	NOUN
admet-2043	721	3	and	and	CCONJ
admet-2043	721	4	methods	method	NOUN
admet-2043	721	5	will	will	AUX
admet-2043	721	6	be	be	AUX
admet-2043	721	7	crucial	crucial	ADJ
admet-2043	721	8	for	for	ADP
admet-2043	721	9	addressing	address	VERB
admet-2043	721	10	these	these	DET
admet-2043	721	11	challenging	challenging	ADJ
admet-2043	721	12	aspects	aspect	NOUN
admet-2043	721	13	.	.	PUNCT
admet-2043	722	1	secondly	secondly	ADV
admet-2043	722	2	,	,	PUNCT
admet-2043	722	3	establishing	establish	VERB
admet-2043	722	4	a	a	DET
admet-2043	722	5	normative	normative	ADJ
admet-2043	722	6	evaluation	evaluation	NOUN
admet-2043	722	7	framework	framework	NOUN
admet-2043	722	8	and	and	CCONJ
admet-2043	722	9	using	use	VERB
admet-2043	722	10	rational	rational	ADJ
admet-2043	722	11	animal	animal	NOUN
admet-2043	722	12	models	model	NOUN
admet-2043	722	13	are	be	AUX
admet-2043	722	14	essential	essential	ADJ
admet-2043	722	15	to	to	PART
admet-2043	722	16	assess	assess	VERB
admet-2043	722	17	the	the	DET
admet-2043	722	18	efficiency	efficiency	NOUN
admet-2043	722	19	of	of	ADP
admet-2043	722	20	nddss	nddss	NOUN
admet-2043	722	21	[	[	X
admet-2043	722	22	209	209	NUM
admet-2043	722	23	]	]	PUNCT
admet-2043	722	24	.	.	PUNCT
admet-2043	723	1	target	target	NOUN
admet-2043	723	2	specificity	specificity	NOUN
admet-2043	723	3	,	,	PUNCT
admet-2043	723	4	tissue	tissue	NOUN
admet-2043	723	5	exposure	exposure	NOUN
admet-2043	723	6	,	,	PUNCT
admet-2043	723	7	safety	safety	NOUN
admet-2043	723	8	profiles	profile	NOUN
admet-2043	723	9	,	,	PUNCT
admet-2043	723	10	patient	patient	ADJ
admet-2043	723	11	considerations	consideration	NOUN
admet-2043	723	12	,	,	PUNCT
admet-2043	723	13	and	and	CCONJ
admet-2043	723	14	commercial	commercial	ADJ
admet-2043	723	15	potential	potential	NOUN
admet-2043	723	16	should	should	AUX
admet-2043	723	17	guide	guide	VERB
admet-2043	723	18	the	the	DET
admet-2043	723	19	evaluation	evaluation	NOUN
admet-2043	723	20	process	process	NOUN
admet-2043	723	21	[	[	X
admet-2043	723	22	210	210	NUM
admet-2043	723	23	]	]	PUNCT
admet-2043	723	24	.	.	PUNCT
admet-2043	724	1	effective	effective	ADJ
admet-2043	724	2	collaboration	collaboration	NOUN
admet-2043	724	3	between	between	ADP
admet-2043	724	4	biologists	biologist	NOUN
admet-2043	724	5	,	,	PUNCT
admet-2043	724	6	mathematicians	mathematician	NOUN
admet-2043	724	7	,	,	PUNCT
admet-2043	724	8	chemists	chemist	NOUN
admet-2043	724	9	,	,	PUNCT
admet-2043	724	10	and	and	CCONJ
admet-2043	724	11	medical	medical	ADJ
admet-2043	724	12	scientists	scientist	NOUN
admet-2043	724	13	is	be	AUX
admet-2043	724	14	crucial	crucial	ADJ
admet-2043	724	15	in	in	ADP
admet-2043	724	16	the	the	DET
admet-2043	724	17	design	design	NOUN
admet-2043	724	18	of	of	ADP
admet-2043	724	19	nanomedicine	nanomedicine	NOUN
admet-2043	724	20	-	-	PUNCT
admet-2043	724	21	based	base	VERB
admet-2043	724	22	drug	drug	NOUN
admet-2043	724	23	delivery	delivery	NOUN
admet-2043	724	24	systems	system	NOUN
admet-2043	724	25	(	(	PUNCT
admet-2043	724	26	nddss	nddss	NOUN
admet-2043	724	27	)	)	PUNCT
admet-2043	724	28	that	that	PRON
admet-2043	724	29	offer	offer	VERB
admet-2043	724	30	clinical	clinical	ADJ
admet-2043	724	31	value	value	NOUN
admet-2043	724	32	.	.	PUNCT
admet-2043	725	1	furthermore	furthermore	ADV
admet-2043	725	2	,	,	PUNCT
admet-2043	725	3	priority	priority	NOUN
admet-2043	725	4	should	should	AUX
admet-2043	725	5	be	be	AUX
admet-2043	725	6	given	give	VERB
admet-2043	725	7	to	to	ADP
admet-2043	725	8	the	the	DET
admet-2043	725	9	development	development	NOUN
admet-2043	725	10	of	of	ADP
admet-2043	725	11	nddss	nddss	NOUN
admet-2043	725	12	that	that	PRON
admet-2043	725	13	are	be	AUX
admet-2043	725	14	structurally	structurally	ADV
admet-2043	725	15	simple	simple	ADJ
admet-2043	725	16	and	and	CCONJ
admet-2043	725	17	reproducible	reproducible	ADJ
admet-2043	725	18	,	,	PUNCT
admet-2043	725	19	as	as	SCONJ
admet-2043	725	20	they	they	PRON
admet-2043	725	21	hold	hold	VERB
admet-2043	725	22	immense	immense	ADJ
admet-2043	725	23	potential	potential	NOUN
admet-2043	725	24	for	for	ADP
admet-2043	725	25	widespread	widespread	ADJ
admet-2043	725	26	patient	patient	ADJ
admet-2043	725	27	access	access	NOUN
admet-2043	725	28	.	.	PUNCT
admet-2043	726	1	although	although	SCONJ
admet-2043	726	2	there	there	PRON
admet-2043	726	3	is	be	VERB
admet-2043	726	4	a	a	DET
admet-2043	726	5	need	need	NOUN
admet-2043	726	6	for	for	ADP
admet-2043	726	7	further	further	ADJ
admet-2043	726	8	advancement	advancement	NOUN
admet-2043	726	9	in	in	ADP
admet-2043	726	10	regulatory	regulatory	ADJ
admet-2043	726	11	mechanisms	mechanism	NOUN
admet-2043	726	12	and	and	CCONJ
admet-2043	726	13	safety	safety	NOUN
admet-2043	726	14	assessments	assessment	NOUN
admet-2043	726	15	for	for	ADP
admet-2043	726	16	nanomedicines	nanomedicine	NOUN
admet-2043	726	17	,	,	PUNCT
admet-2043	726	18	it	it	PRON
admet-2043	726	19	is	be	AUX
admet-2043	726	20	important	important	ADJ
admet-2043	726	21	to	to	PART
admet-2043	726	22	recognize	recognize	VERB
admet-2043	726	23	that	that	SCONJ
admet-2043	726	24	nanomedicine	nanomedicine	NOUN
admet-2043	726	25	has	have	AUX
admet-2043	726	26	already	already	ADV
admet-2043	726	27	brought	bring	VERB
admet-2043	726	28	a	a	DET
admet-2043	726	29	transformative	transformative	ADJ
admet-2043	726	30	shift	shift	NOUN
admet-2043	726	31	in	in	ADP
admet-2043	726	32	drug	drug	NOUN
admet-2043	726	33	discovery	discovery	NOUN
admet-2043	726	34	and	and	CCONJ
admet-2043	726	35	administration	administration	NOUN
admet-2043	726	36	within	within	ADP
admet-2043	726	37	biological	biological	ADJ
admet-2043	726	38	systems	system	NOUN
admet-2043	726	39	.	.	PUNCT
admet-2043	727	1	by	by	ADP
admet-2043	727	2	leveraging	leverage	VERB
admet-2043	727	3	stimuli	stimulus	NOUN
admet-2043	727	4	-	-	PUNCT
admet-2043	727	5	responsive	responsive	ADJ
admet-2043	727	6	materials	material	NOUN
admet-2043	727	7	and	and	CCONJ
admet-2043	727	8	advanced	advanced	ADJ
admet-2043	727	9	nanotechnology	nanotechnology	NOUN
admet-2043	727	10	,	,	PUNCT
admet-2043	727	11	these	these	DET
admet-2043	727	12	systems	system	NOUN
admet-2043	727	13	offer	offer	VERB
admet-2043	727	14	precise	precise	ADJ
admet-2043	727	15	control	control	NOUN
admet-2043	727	16	over	over	ADP
admet-2043	727	17	drug	drug	NOUN
admet-2043	727	18	release	release	NOUN
admet-2043	727	19	,	,	PUNCT
admet-2043	727	20	improving	improve	VERB
admet-2043	727	21	therapeutic	therapeutic	ADJ
admet-2043	727	22	efficacy	efficacy	NOUN
admet-2043	727	23	while	while	SCONJ
admet-2043	727	24	minimizing	minimize	VERB
admet-2043	727	25	off	off	ADP
admet-2043	727	26	-	-	PUNCT
admet-2043	727	27	target	target	NOUN
admet-2043	727	28	effects	effect	NOUN
admet-2043	727	29	[	[	X
admet-2043	727	30	211	211	NUM
admet-2043	727	31	]	]	PUNCT
admet-2043	727	32	.	.	PUNCT
admet-2043	728	1	noninvasive	noninvasive	ADJ
admet-2043	728	2	delivery	delivery	NOUN
admet-2043	728	3	methods	method	NOUN
admet-2043	728	4	such	such	ADJ
admet-2043	728	5	as	as	ADP
admet-2043	728	6	intranasal	intranasal	ADJ
admet-2043	728	7	delivery	delivery	NOUN
admet-2043	728	8	,	,	PUNCT
admet-2043	728	9	focused	focus	VERB
admet-2043	728	10	ultrasound	ultrasound	NOUN
admet-2043	728	11	,	,	PUNCT
admet-2043	728	12	and	and	CCONJ
admet-2043	728	13	magnetic	magnetic	ADJ
admet-2043	728	14	targeting	targeting	NOUN
admet-2043	728	15	are	be	AUX
admet-2043	728	16	being	be	AUX
admet-2043	728	17	explored	explore	VERB
admet-2043	728	18	to	to	PART
admet-2043	728	19	overcome	overcome	VERB
admet-2043	728	20	the	the	DET
admet-2043	728	21	bbb	bbb	NOUN
admet-2043	728	22	without	without	ADP
admet-2043	728	23	invasive	invasive	ADJ
admet-2043	728	24	procedures	procedure	NOUN
admet-2043	728	25	,	,	PUNCT
admet-2043	728	26	enhancing	enhance	VERB
admet-2043	728	27	drug	drug	NOUN
admet-2043	728	28	delivery	delivery	NOUN
admet-2043	728	29	efficiency	efficiency	NOUN
admet-2043	728	30	and	and	CCONJ
admet-2043	728	31	reducing	reduce	VERB
admet-2043	728	32	associated	associated	ADJ
admet-2043	728	33	risks	risk	NOUN
admet-2043	728	34	.	.	PUNCT
admet-2043	729	1	combination	combination	NOUN
admet-2043	729	2	therapies	therapy	NOUN
admet-2043	729	3	utilizing	utilize	VERB
admet-2043	729	4	nms	nms	PROPN
admet-2043	729	5	present	present	ADJ
admet-2043	729	6	an	an	DET
admet-2043	729	7	opportunity	opportunity	NOUN
admet-2043	729	8	to	to	PART
admet-2043	729	9	synergistically	synergistically	ADV
admet-2043	729	10	target	target	VERB
admet-2043	729	11	multiple	multiple	ADJ
admet-2043	729	12	pathways	pathway	NOUN
admet-2043	729	13	in	in	ADP
admet-2043	729	14	neurological	neurological	ADJ
admet-2043	729	15	disorders	disorder	NOUN
admet-2043	729	16	,	,	PUNCT
admet-2043	729	17	leading	lead	VERB
admet-2043	729	18	to	to	ADP
admet-2043	729	19	improved	improve	VERB
admet-2043	729	20	treatment	treatment	NOUN
admet-2043	729	21	outcomes	outcome	NOUN
admet-2043	729	22	[	[	X
admet-2043	729	23	212	212	NUM
admet-2043	729	24	]	]	PUNCT
admet-2043	729	25	.	.	PUNCT
admet-2043	730	1	personalized	personalize	VERB
admet-2043	730	2	medicine	medicine	NOUN
admet-2043	730	3	approaches	approach	NOUN
admet-2043	730	4	tailored	tailor	VERB
admet-2043	730	5	to	to	ADP
admet-2043	730	6	individual	individual	ADJ
admet-2043	730	7	patient	patient	NOUN
admet-2043	730	8	characteristics	characteristic	NOUN
admet-2043	730	9	,	,	PUNCT
admet-2043	730	10	including	include	VERB
admet-2043	730	11	genetic	genetic	ADJ
admet-2043	730	12	profiles	profile	NOUN
admet-2043	730	13	and	and	CCONJ
admet-2043	730	14	disease	disease	NOUN
admet-2043	730	15	subtypes	subtype	NOUN
admet-2043	730	16	,	,	PUNCT
admet-2043	730	17	can	can	AUX
admet-2043	730	18	optimize	optimize	VERB
admet-2043	730	19	treatment	treatment	NOUN
admet-2043	730	20	effectiveness	effectiveness	NOUN
admet-2043	730	21	.	.	PUNCT
admet-2043	731	1	regulatory	regulatory	ADJ
admet-2043	731	2	considerations	consideration	NOUN
admet-2043	731	3	need	need	VERB
admet-2043	731	4	to	to	PART
admet-2043	731	5	be	be	AUX
admet-2043	731	6	addressed	address	VERB
admet-2043	731	7	to	to	PART
admet-2043	731	8	adapt	adapt	VERB
admet-2043	731	9	to	to	ADP
admet-2043	731	10	the	the	DET
admet-2043	731	11	unique	unique	ADJ
admet-2043	731	12	challenges	challenge	NOUN
admet-2043	731	13	of	of	ADP
admet-2043	731	14	nanomaterial	nanomaterial	NOUN
admet-2043	731	15	-	-	PUNCT
admet-2043	731	16	based	base	VERB
admet-2043	731	17	drug	drug	NOUN
admet-2043	731	18	delivery	delivery	NOUN
admet-2043	731	19	systems	system	NOUN
admet-2043	731	20	.	.	PUNCT
admet-2043	732	1	this	this	PRON
admet-2043	732	2	involves	involve	VERB
admet-2043	732	3	developing	develop	VERB
admet-2043	732	4	standardized	standardized	ADJ
admet-2043	732	5	evaluation	evaluation	NOUN
admet-2043	732	6	protocols	protocol	NOUN
admet-2043	732	7	to	to	PART
admet-2043	732	8	ensure	ensure	VERB
admet-2043	732	9	patient	patient	ADJ
admet-2043	732	10	safety	safety	NOUN
admet-2043	732	11	and	and	CCONJ
admet-2043	732	12	facilitate	facilitate	VERB
admet-2043	732	13	regulatory	regulatory	ADJ
admet-2043	732	14	approval	approval	NOUN
admet-2043	732	15	[	[	X
admet-2043	732	16	213	213	NUM
admet-2043	732	17	]	]	PUNCT
admet-2043	732	18	.	.	PUNCT
admet-2043	733	1	future	future	ADJ
admet-2043	733	2	research	research	NOUN
admet-2043	733	3	will	will	AUX
admet-2043	733	4	prioritize	prioritize	VERB
admet-2043	733	5	the	the	DET
admet-2043	733	6	development	development	NOUN
admet-2043	733	7	of	of	ADP
admet-2043	733	8	scalable	scalable	ADJ
admet-2043	733	9	manufacturing	manufacturing	NOUN
admet-2043	733	10	techniques	technique	NOUN
admet-2043	733	11	for	for	ADP
admet-2043	733	12	nanomaterials	nanomaterial	NOUN
admet-2043	733	13	utilized	utilize	VERB
admet-2043	733	14	in	in	ADP
admet-2043	733	15	drug	drug	NOUN
admet-2043	733	16	delivery	delivery	NOUN
admet-2043	733	17	applications	application	NOUN
admet-2043	733	18	[	[	X
admet-2043	733	19	214	214	NUM
admet-2043	733	20	]	]	PUNCT
admet-2043	733	21	.	.	PUNCT
admet-2043	734	1	the	the	DET
admet-2043	734	2	primary	primary	ADJ
admet-2043	734	3	focus	focus	NOUN
admet-2043	734	4	will	will	AUX
admet-2043	734	5	involve	involve	VERB
admet-2043	734	6	enhancing	enhance	VERB
admet-2043	734	7	the	the	DET
admet-2043	734	8	synthesis	synthesis	NOUN
admet-2043	734	9	and	and	CCONJ
admet-2043	734	10	fabrication	fabrication	NOUN
admet-2043	734	11	methods	method	NOUN
admet-2043	734	12	to	to	PART
admet-2043	734	13	achieve	achieve	VERB
admet-2043	734	14	reproducibility	reproducibility	NOUN
admet-2043	734	15	,	,	PUNCT
admet-2043	734	16	cost	cost	NOUN
admet-2043	734	17	-	-	PUNCT
admet-2043	734	18	effectiveness	effectiveness	NOUN
admet-2043	734	19	,	,	PUNCT
admet-2043	734	20	and	and	CCONJ
admet-2043	734	21	the	the	DET
admet-2043	734	22	ability	ability	NOUN
admet-2043	734	23	to	to	PART
admet-2043	734	24	produce	produce	VERB
admet-2043	734	25	on	on	ADP
admet-2043	734	26	a	a	DET
admet-2043	734	27	large	large	ADJ
admet-2043	734	28	scale	scale	NOUN
admet-2043	734	29	.	.	PUNCT
admet-2043	735	1	several	several	ADJ
admet-2043	735	2	examples	example	NOUN
admet-2043	735	3	of	of	ADP
admet-2043	735	4	scalable	scalable	ADJ
admet-2043	735	5	manufacturing	manufacturing	NOUN
admet-2043	735	6	processes	process	NOUN
admet-2043	735	7	include	include	VERB
admet-2043	735	8	continuous	continuous	ADJ
admet-2043	735	9	flow	flow	NOUN
admet-2043	735	10	synthesis	synthesis	NOUN
admet-2043	735	11	,	,	PUNCT
admet-2043	735	12	spray	spray	VERB
admet-2043	735	13	drying	drying	NOUN
admet-2043	735	14	,	,	PUNCT
admet-2043	735	15	and	and	CCONJ
admet-2043	735	16	microfluidics	microfluidic	NOUN
admet-2043	735	17	.	.	PUNCT
admet-2043	736	1	these	these	DET
admet-2043	736	2	methods	method	NOUN
admet-2043	736	3	offer	offer	VERB
admet-2043	736	4	efficient	efficient	ADJ
admet-2043	736	5	and	and	CCONJ
admet-2043	736	6	high	high	ADJ
admet-2043	736	7	-	-	PUNCT
admet-2043	736	8	throughput	throughput	NOUN
admet-2043	736	9	production	production	NOUN
admet-2043	736	10	of	of	ADP
admet-2043	736	11	nms	nms	NOUN
admet-2043	736	12	,	,	PUNCT
admet-2043	736	13	allowing	allow	VERB
admet-2043	736	14	for	for	ADP
admet-2043	736	15	precise	precise	ADJ
admet-2043	736	16	control	control	NOUN
admet-2043	736	17	over	over	ADP
admet-2043	736	18	particle	particle	NOUN
admet-2043	736	19	size	size	NOUN
admet-2043	736	20	,	,	PUNCT
admet-2043	736	21	shape	shape	NOUN
admet-2043	736	22	,	,	PUNCT
admet-2043	736	23	and	and	CCONJ
admet-2043	736	24	surface	surface	NOUN
admet-2043	736	25	properties	property	NOUN
admet-2043	736	26	[	[	X
admet-2043	736	27	215	215	NUM
admet-2043	736	28	]	]	PUNCT
admet-2043	736	29	.	.	PUNCT
admet-2043	737	1	the	the	DET
admet-2043	737	2	advantages	advantage	NOUN
admet-2043	737	3	of	of	ADP
admet-2043	737	4	scalable	scalable	ADJ
admet-2043	737	5	manufacturing	manufacturing	NOUN
admet-2043	737	6	processes	process	NOUN
admet-2043	737	7	in	in	ADP
admet-2043	737	8	this	this	DET
admet-2043	737	9	context	context	NOUN
admet-2043	737	10	are	be	AUX
admet-2043	737	11	numerous	numerous	ADJ
admet-2043	737	12	.	.	PUNCT
admet-2043	738	1	large	large	ADJ
admet-2043	738	2	-	-	PUNCT
admet-2043	738	3	scale	scale	NOUN
admet-2043	738	4	production	production	NOUN
admet-2043	738	5	facilitates	facilitate	VERB
admet-2043	738	6	broader	broad	ADJ
admet-2043	738	7	availability	availability	NOUN
admet-2043	738	8	of	of	ADP
admet-2043	738	9	drug	drug	NOUN
admet-2043	738	10	delivery	delivery	NOUN
admet-2043	738	11	systems	system	NOUN
admet-2043	738	12	based	base	VERB
admet-2043	738	13	on	on	ADP
admet-2043	738	14	nms	nms	NOUN
admet-2043	738	15	,	,	PUNCT
admet-2043	738	16	increasing	increase	VERB
admet-2043	738	17	patient	patient	ADJ
admet-2043	738	18	access	access	NOUN
admet-2043	738	19	.	.	PUNCT
admet-2043	739	1	moreover	moreover	ADV
admet-2043	739	2	,	,	PUNCT
admet-2043	739	3	such	such	ADJ
admet-2043	739	4	processes	process	NOUN
admet-2043	739	5	can	can	AUX
admet-2043	739	6	substantially	substantially	ADV
admet-2043	739	7	reduce	reduce	VERB
admet-2043	739	8	production	production	NOUN
admet-2043	739	9	costs	cost	NOUN
admet-2043	739	10	,	,	PUNCT
admet-2043	739	11	making	make	VERB
admet-2043	739	12	nanomedicine	nanomedicine	NOUN
admet-2043	739	13	-	-	PUNCT
admet-2043	739	14	based	base	VERB
admet-2043	739	15	therapies	therapy	NOUN
admet-2043	739	16	more	more	ADV
admet-2043	739	17	affordable	affordable	ADJ
admet-2043	739	18	and	and	CCONJ
admet-2043	739	19	accessible	accessible	ADJ
admet-2043	739	20	.	.	PUNCT
admet-2043	740	1	improved	improved	ADJ
admet-2043	740	2	reproducibility	reproducibility	NOUN
admet-2043	740	3	ensures	ensure	VERB
admet-2043	740	4	consistent	consistent	ADJ
admet-2043	740	5	quality	quality	NOUN
admet-2043	740	6	and	and	CCONJ
admet-2043	740	7	performance	performance	NOUN
admet-2043	740	8	of	of	ADP
admet-2043	740	9	the	the	DET
admet-2043	740	10	nms	nms	NOUN
admet-2043	740	11	,	,	PUNCT
admet-2043	740	12	thereby	thereby	ADV
admet-2043	740	13	enhancing	enhance	VERB
admet-2043	740	14	the	the	DET
admet-2043	740	15	reliability	reliability	NOUN
admet-2043	740	16	of	of	ADP
admet-2043	740	17	drug	drug	NOUN
admet-2043	740	18	delivery	delivery	NOUN
admet-2043	740	19	systems	system	NOUN
admet-2043	740	20	.	.	PUNCT
admet-2043	741	1	nonetheless	nonetheless	ADV
admet-2043	741	2	,	,	PUNCT
admet-2043	741	3	there	there	PRON
admet-2043	741	4	are	be	VERB
admet-2043	741	5	certain	certain	ADJ
admet-2043	741	6	drawbacks	drawback	NOUN
admet-2043	741	7	to	to	PART
admet-2043	741	8	consider	consider	VERB
admet-2043	741	9	.	.	PUNCT
admet-2043	742	1	scaling	scale	VERB
admet-2043	742	2	up	up	ADP
admet-2043	742	3	the	the	DET
admet-2043	742	4	production	production	NOUN
admet-2043	742	5	process	process	NOUN
admet-2043	742	6	may	may	AUX
admet-2043	742	7	introduce	introduce	VERB
admet-2043	742	8	challenges	challenge	NOUN
admet-2043	742	9	in	in	ADP
admet-2043	742	10	preserving	preserve	VERB
admet-2043	742	11	the	the	DET
admet-2043	742	12	stability	stability	NOUN
admet-2043	742	13	and	and	CCONJ
admet-2043	742	14	integrity	integrity	NOUN
admet-2043	742	15	of	of	ADP
admet-2043	742	16	nms	nms	PROPN
admet-2043	742	17	[	[	X
admet-2043	742	18	216	216	NUM
admet-2043	742	19	]	]	PUNCT
admet-2043	742	20	.	.	PUNCT
admet-2043	743	1	it	it	PRON
admet-2043	743	2	becomes	become	VERB
admet-2043	743	3	increasingly	increasingly	ADV
admet-2043	743	4	crucial	crucial	ADJ
admet-2043	743	5	to	to	PART
admet-2043	743	6	ensure	ensure	VERB
admet-2043	743	7	batch	batch	VERB
admet-2043	743	8	-	-	PUNCT
admet-2043	743	9	to	to	ADP
admet-2043	743	10	-	-	PUNCT
admet-2043	743	11	batch	batch	NOUN
admet-2043	743	12	consistency	consistency	NOUN
admet-2043	743	13	as	as	SCONJ
admet-2043	743	14	the	the	DET
admet-2043	743	15	production	production	NOUN
admet-2043	743	16	volume	volume	NOUN
admet-2043	743	17	expands	expand	VERB
admet-2043	743	18	.	.	PUNCT
admet-2043	744	1	additionally	additionally	ADV
admet-2043	744	2	,	,	PUNCT
admet-2043	744	3	complex	complex	ADJ
admet-2043	744	4	manufacturing	manufacturing	NOUN
admet-2043	744	5	processes	process	NOUN
admet-2043	744	6	may	may	AUX
admet-2043	744	7	require	require	VERB
admet-2043	744	8	sophisticated	sophisticated	ADJ
admet-2043	744	9	equipment	equipment	NOUN
admet-2043	744	10	and	and	CCONJ
admet-2043	744	11	specialized	specialized	ADJ
admet-2043	744	12	expertise	expertise	NOUN
admet-2043	744	13	,	,	PUNCT
admet-2043	744	14	leading	lead	VERB
admet-2043	744	15	to	to	ADP
admet-2043	744	16	additional	additional	ADJ
admet-2043	744	17	initial	initial	ADJ
admet-2043	744	18	setup	setup	NOUN
admet-2043	744	19	and	and	CCONJ
admet-2043	744	20	operational	operational	ADJ
admet-2043	744	21	expenses	expense	NOUN
admet-2043	744	22	.	.	PUNCT
admet-2043	745	1	regulatory	regulatory	ADJ
admet-2043	745	2	compliance	compliance	NOUN
admet-2043	745	3	and	and	CCONJ
admet-2043	745	4	quality	quality	NOUN
admet-2043	745	5	control	control	NOUN
admet-2043	745	6	have	have	AUX
admet-2043	745	7	also	also	ADV
admet-2043	745	8	become	become	VERB
admet-2043	745	9	essential	essential	ADJ
admet-2043	745	10	in	in	ADP
admet-2043	745	11	large	large	ADJ
admet-2043	745	12	-	-	PUNCT
admet-2043	745	13	scale	scale	NOUN
admet-2043	745	14	production	production	NOUN
admet-2043	745	15	to	to	PART
admet-2043	745	16	ensure	ensure	VERB
admet-2043	745	17	the	the	DET
admet-2043	745	18	safety	safety	NOUN
admet-2043	745	19	and	and	CCONJ
admet-2043	745	20	efficacy	efficacy	NOUN
admet-2043	745	21	of	of	ADP
admet-2043	745	22	the	the	DET
admet-2043	745	23	resulting	result	VERB
admet-2043	745	24	products	product	NOUN
admet-2043	745	25	[	[	X
admet-2043	745	26	217	217	NUM
admet-2043	745	27	]	]	PUNCT
admet-2043	745	28	.	.	PUNCT
admet-2043	746	1	as	as	SCONJ
admet-2043	746	2	the	the	DET
admet-2043	746	3	production	production	NOUN
admet-2043	746	4	of	of	ADP
admet-2043	746	5	nanomaterial	nanomaterial	NOUN
admet-2043	746	6	-	-	PUNCT
admet-2043	746	7	based	base	VERB
admet-2043	746	8	drug	drug	NOUN
admet-2043	746	9	delivery	delivery	NOUN
admet-2043	746	10	systems	system	NOUN
admet-2043	746	11	expands	expand	VERB
admet-2043	746	12	,	,	PUNCT
admet-2043	746	13	the	the	DET
admet-2043	746	14	implementation	implementation	NOUN
admet-2043	746	15	of	of	ADP
admet-2043	746	16	robust	robust	ADJ
admet-2043	746	17	quality	quality	NOUN
admet-2043	746	18	control	control	NOUN
admet-2043	746	19	measures	measure	NOUN
admet-2043	746	20	and	and	CCONJ
admet-2043	746	21	advanced	advanced	ADJ
admet-2043	746	22	characterization	characterization	NOUN
admet-2043	746	23	techniques	technique	NOUN
admet-2043	746	24	becomes	become	VERB
admet-2043	746	25	vital	vital	ADJ
admet-2043	746	26	to	to	PART
admet-2043	746	27	assess	assess	VERB
admet-2043	746	28	their	their	PRON
admet-2043	746	29	integrity	integrity	NOUN
admet-2043	746	30	,	,	PUNCT
admet-2043	746	31	admet	admet	PROPN
admet-2043	746	32	&	&	CCONJ
admet-2043	746	33	dmpk	dmpk	PROPN
admet-2043	746	34	12(1	12(1	PROPN
admet-2043	746	35	)	)	PUNCT
admet-2043	746	36	(	(	PUNCT
admet-2043	746	37	2024	2024	NUM
admet-2043	746	38	)	)	PUNCT
admet-2043	746	39	63	63	NUM
admet-2043	746	40	-	-	SYM
admet-2043	746	41	105	105	NUM
admet-2043	746	42	nanomaterials	nanomaterial	NOUN
admet-2043	746	43	as	as	ADP
admet-2043	746	44	drug	drug	NOUN
admet-2043	746	45	delivery	delivery	NOUN
admet-2043	746	46	agents	agent	NOUN
admet-2043	746	47	for	for	ADP
admet-2043	746	48	overcoming	overcome	VERB
admet-2043	746	49	bbb	bbb	PROPN
admet-2043	746	50	doi	doi	NOUN
admet-2043	746	51	:	:	PUNCT
admet-2043	746	52	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	746	53	91	91	NUM
admet-2043	746	54	safety	safety	NOUN
admet-2043	746	55	,	,	PUNCT
admet-2043	746	56	and	and	CCONJ
admet-2043	746	57	performance	performance	NOUN
admet-2043	746	58	[	[	X
admet-2043	746	59	218	218	NUM
admet-2043	746	60	]	]	PUNCT
admet-2043	746	61	.	.	PUNCT
admet-2043	747	1	establishing	establish	VERB
admet-2043	747	2	standardized	standardized	ADJ
admet-2043	747	3	protocols	protocol	NOUN
admet-2043	747	4	and	and	CCONJ
admet-2043	747	5	guidelines	guideline	NOUN
admet-2043	747	6	for	for	ADP
admet-2043	747	7	quality	quality	NOUN
admet-2043	747	8	control	control	NOUN
admet-2043	747	9	testing	testing	NOUN
admet-2043	747	10	,	,	PUNCT
admet-2043	747	11	encompassing	encompass	VERB
admet-2043	747	12	physical	physical	ADJ
admet-2043	747	13	and	and	CCONJ
admet-2043	747	14	chemical	chemical	NOUN
admet-2043	747	15	characterization	characterization	NOUN
admet-2043	747	16	,	,	PUNCT
admet-2043	747	17	particle	particle	NOUN
admet-2043	747	18	size	size	NOUN
admet-2043	747	19	analysis	analysis	NOUN
admet-2043	747	20	,	,	PUNCT
admet-2043	747	21	surface	surface	NOUN
admet-2043	747	22	charge	charge	NOUN
admet-2043	747	23	determination	determination	NOUN
admet-2043	747	24	,	,	PUNCT
admet-2043	747	25	and	and	CCONJ
admet-2043	747	26	drug	drug	NOUN
admet-2043	747	27	loading	loading	NOUN
admet-2043	747	28	efficiency	efficiency	NOUN
admet-2043	747	29	,	,	PUNCT
admet-2043	747	30	is	be	AUX
admet-2043	747	31	essential	essential	ADJ
admet-2043	747	32	.	.	PUNCT
admet-2043	748	1	these	these	DET
admet-2043	748	2	measures	measure	NOUN
admet-2043	748	3	ensure	ensure	VERB
admet-2043	748	4	consistency	consistency	NOUN
admet-2043	748	5	,	,	PUNCT
admet-2043	748	6	meet	meet	VERB
admet-2043	748	7	regulatory	regulatory	ADJ
admet-2043	748	8	requirements	requirement	NOUN
admet-2043	748	9	,	,	PUNCT
admet-2043	748	10	and	and	CCONJ
admet-2043	748	11	provide	provide	VERB
admet-2043	748	12	valuable	valuable	ADJ
admet-2043	748	13	insights	insight	NOUN
admet-2043	748	14	.	.	PUNCT
admet-2043	749	1	the	the	DET
admet-2043	749	2	advantages	advantage	NOUN
admet-2043	749	3	of	of	ADP
admet-2043	749	4	implementing	implement	VERB
admet-2043	749	5	quality	quality	NOUN
admet-2043	749	6	control	control	NOUN
admet-2043	749	7	and	and	CCONJ
admet-2043	749	8	characterization	characterization	NOUN
admet-2043	749	9	processes	process	NOUN
admet-2043	749	10	are	be	AUX
admet-2043	749	11	manifold	manifold	ADJ
admet-2043	749	12	.	.	PUNCT
admet-2043	750	1	rigorous	rigorous	ADJ
admet-2043	750	2	quality	quality	NOUN
admet-2043	750	3	control	control	NOUN
admet-2043	750	4	guarantees	guarantee	VERB
admet-2043	750	5	the	the	DET
admet-2043	750	6	reliability	reliability	NOUN
admet-2043	750	7	,	,	PUNCT
admet-2043	750	8	safety	safety	NOUN
admet-2043	750	9	,	,	PUNCT
admet-2043	750	10	and	and	CCONJ
admet-2043	750	11	efficacy	efficacy	NOUN
admet-2043	750	12	of	of	ADP
admet-2043	750	13	nanomaterial	nanomaterial	NOUN
admet-2043	750	14	-	-	PUNCT
admet-2043	750	15	based	base	VERB
admet-2043	750	16	drug	drug	NOUN
admet-2043	750	17	delivery	delivery	NOUN
admet-2043	750	18	systems	system	NOUN
admet-2043	750	19	.	.	PUNCT
admet-2043	751	1	standardized	standardized	ADJ
admet-2043	751	2	protocols	protocol	NOUN
admet-2043	751	3	enable	enable	VERB
admet-2043	751	4	comparison	comparison	NOUN
admet-2043	751	5	and	and	CCONJ
admet-2043	751	6	evaluation	evaluation	NOUN
admet-2043	751	7	of	of	ADP
admet-2043	751	8	different	different	ADJ
admet-2043	751	9	production	production	NOUN
admet-2043	751	10	batches	batch	NOUN
admet-2043	751	11	,	,	PUNCT
admet-2043	751	12	ensuring	ensure	VERB
admet-2043	751	13	consistency	consistency	NOUN
admet-2043	751	14	and	and	CCONJ
admet-2043	751	15	quality	quality	NOUN
admet-2043	751	16	assurance	assurance	NOUN
admet-2043	751	17	[	[	X
admet-2043	751	18	219	219	NUM
admet-2043	751	19	]	]	PUNCT
admet-2043	751	20	.	.	PUNCT
admet-2043	752	1	advanced	advanced	ADJ
admet-2043	752	2	characterization	characterization	NOUN
admet-2043	752	3	techniques	technique	NOUN
admet-2043	752	4	provide	provide	VERB
admet-2043	752	5	a	a	DET
admet-2043	752	6	comprehensive	comprehensive	ADJ
admet-2043	752	7	understanding	understanding	NOUN
admet-2043	752	8	of	of	ADP
admet-2043	752	9	the	the	DET
admet-2043	752	10	nms	nms	NOUN
admet-2043	752	11	'	'	PART
admet-2043	752	12	physicochemical	physicochemical	ADJ
admet-2043	752	13	properties	property	NOUN
admet-2043	752	14	and	and	CCONJ
admet-2043	752	15	performance	performance	NOUN
admet-2043	752	16	,	,	PUNCT
admet-2043	752	17	facilitating	facilitate	VERB
admet-2043	752	18	optimization	optimization	NOUN
admet-2043	752	19	and	and	CCONJ
admet-2043	752	20	further	further	ADJ
admet-2043	752	21	development	development	NOUN
admet-2043	752	22	.	.	PUNCT
admet-2043	753	1	nevertheless	nevertheless	ADV
admet-2043	753	2	,	,	PUNCT
admet-2043	753	3	there	there	PRON
admet-2043	753	4	are	be	VERB
admet-2043	753	5	certain	certain	ADJ
admet-2043	753	6	disadvantages	disadvantage	NOUN
admet-2043	753	7	to	to	PART
admet-2043	753	8	consider	consider	VERB
admet-2043	753	9	[	[	X
admet-2043	753	10	220	220	NUM
admet-2043	753	11	]	]	PUNCT
admet-2043	753	12	.	.	PUNCT
admet-2043	754	1	the	the	DET
admet-2043	754	2	implementation	implementation	NOUN
admet-2043	754	3	of	of	ADP
admet-2043	754	4	comprehensive	comprehensive	ADJ
admet-2043	754	5	quality	quality	NOUN
admet-2043	754	6	control	control	NOUN
admet-2043	754	7	measures	measure	NOUN
admet-2043	754	8	introduces	introduce	VERB
admet-2043	754	9	complexity	complexity	NOUN
admet-2043	754	10	and	and	CCONJ
admet-2043	754	11	additional	additional	ADJ
admet-2043	754	12	costs	cost	NOUN
admet-2043	754	13	to	to	ADP
admet-2043	754	14	the	the	DET
admet-2043	754	15	production	production	NOUN
admet-2043	754	16	process	process	NOUN
admet-2043	754	17	.	.	PUNCT
admet-2043	755	1	advanced	advanced	ADJ
admet-2043	755	2	characterization	characterization	NOUN
admet-2043	755	3	techniques	technique	NOUN
admet-2043	755	4	may	may	AUX
admet-2043	755	5	require	require	VERB
admet-2043	755	6	specialized	specialized	ADJ
admet-2043	755	7	equipment	equipment	NOUN
admet-2043	755	8	,	,	PUNCT
admet-2043	755	9	expertise	expertise	NOUN
admet-2043	755	10	,	,	PUNCT
admet-2043	755	11	and	and	CCONJ
admet-2043	755	12	time	time	NOUN
admet-2043	755	13	,	,	PUNCT
admet-2043	755	14	potentially	potentially	ADV
admet-2043	755	15	impacting	impact	VERB
admet-2043	755	16	production	production	NOUN
admet-2043	755	17	timelines	timeline	NOUN
admet-2043	755	18	and	and	CCONJ
admet-2043	755	19	expenses	expense	NOUN
admet-2043	755	20	.	.	PUNCT
admet-2043	756	1	the	the	DET
admet-2043	756	2	large	large	ADJ
admet-2043	756	3	-	-	PUNCT
admet-2043	756	4	scale	scale	NOUN
admet-2043	756	5	production	production	NOUN
admet-2043	756	6	of	of	ADP
admet-2043	756	7	nanomaterial	nanomaterial	NOUN
admet-2043	756	8	-	-	PUNCT
admet-2043	756	9	based	base	VERB
admet-2043	756	10	drug	drug	NOUN
admet-2043	756	11	delivery	delivery	NOUN
admet-2043	756	12	systems	system	NOUN
admet-2043	756	13	necessitates	necessitate	VERB
admet-2043	756	14	strict	strict	ADJ
admet-2043	756	15	adherence	adherence	NOUN
admet-2043	756	16	to	to	ADP
admet-2043	756	17	regulatory	regulatory	ADJ
admet-2043	756	18	guidelines	guideline	NOUN
admet-2043	756	19	and	and	CCONJ
admet-2043	756	20	safety	safety	NOUN
admet-2043	756	21	assessments	assessment	NOUN
admet-2043	756	22	to	to	PART
admet-2043	756	23	ensure	ensure	VERB
admet-2043	756	24	patient	patient	ADJ
admet-2043	756	25	safety	safety	NOUN
admet-2043	756	26	and	and	CCONJ
admet-2043	756	27	facilitate	facilitate	VERB
admet-2043	756	28	regulatory	regulatory	ADJ
admet-2043	756	29	approval	approval	NOUN
admet-2043	756	30	.	.	PUNCT
admet-2043	757	1	regulatory	regulatory	ADJ
admet-2043	757	2	agencies	agency	NOUN
admet-2043	757	3	are	be	AUX
admet-2043	757	4	continuously	continuously	ADV
admet-2043	757	5	updating	update	VERB
admet-2043	757	6	and	and	CCONJ
admet-2043	757	7	refining	refine	VERB
admet-2043	757	8	their	their	PRON
admet-2043	757	9	guidelines	guideline	NOUN
admet-2043	757	10	for	for	ADP
admet-2043	757	11	the	the	DET
admet-2043	757	12	regulation	regulation	NOUN
admet-2043	757	13	of	of	ADP
admet-2043	757	14	nanomedicine	nanomedicine	ADJ
admet-2043	757	15	products	product	NOUN
admet-2043	757	16	[	[	X
admet-2043	757	17	221	221	NUM
admet-2043	757	18	]	]	PUNCT
admet-2043	757	19	.	.	PUNCT
admet-2043	758	1	prospects	prospect	NOUN
admet-2043	758	2	involve	involve	VERB
admet-2043	758	3	harmonizing	harmonize	VERB
admet-2043	758	4	regulatory	regulatory	ADJ
admet-2043	758	5	requirements	requirement	NOUN
admet-2043	758	6	to	to	PART
admet-2043	758	7	establish	establish	VERB
admet-2043	758	8	clear	clear	ADJ
admet-2043	758	9	pathways	pathway	NOUN
admet-2043	758	10	for	for	ADP
admet-2043	758	11	the	the	DET
admet-2043	758	12	approval	approval	NOUN
admet-2043	758	13	and	and	CCONJ
admet-2043	758	14	commercialization	commercialization	NOUN
admet-2043	758	15	of	of	ADP
admet-2043	758	16	nanomaterial	nanomaterial	NOUN
admet-2043	758	17	-	-	PUNCT
admet-2043	758	18	based	base	VERB
admet-2043	758	19	drug	drug	NOUN
admet-2043	758	20	delivery	delivery	NOUN
admet-2043	758	21	systems	system	NOUN
admet-2043	758	22	[	[	X
admet-2043	758	23	222	222	NUM
admet-2043	758	24	]	]	PUNCT
admet-2043	758	25	.	.	PUNCT
admet-2043	759	1	adhering	adhere	VERB
admet-2043	759	2	to	to	ADP
admet-2043	759	3	regulatory	regulatory	ADJ
admet-2043	759	4	guidelines	guideline	NOUN
admet-2043	759	5	offers	offer	VERB
admet-2043	759	6	several	several	ADJ
admet-2043	759	7	advantages	advantage	NOUN
admet-2043	759	8	.	.	PUNCT
admet-2043	760	1	it	it	PRON
admet-2043	760	2	ensures	ensure	VERB
admet-2043	760	3	the	the	DET
admet-2043	760	4	safety	safety	NOUN
admet-2043	760	5	,	,	PUNCT
admet-2043	760	6	quality	quality	NOUN
admet-2043	760	7	,	,	PUNCT
admet-2043	760	8	and	and	CCONJ
admet-2043	760	9	efficacy	efficacy	NOUN
admet-2043	760	10	of	of	ADP
admet-2043	760	11	nanomaterialbased	nanomaterialbased	ADJ
admet-2043	760	12	drug	drug	NOUN
admet-2043	760	13	delivery	delivery	NOUN
admet-2043	760	14	systems	system	NOUN
admet-2043	760	15	.	.	PUNCT
admet-2043	761	1	regulatory	regulatory	ADJ
admet-2043	761	2	approval	approval	NOUN
admet-2043	761	3	provides	provide	VERB
admet-2043	761	4	a	a	DET
admet-2043	761	5	framework	framework	NOUN
admet-2043	761	6	for	for	ADP
admet-2043	761	7	market	market	NOUN
admet-2043	761	8	access	access	NOUN
admet-2043	761	9	and	and	CCONJ
admet-2043	761	10	clinical	clinical	ADJ
admet-2043	761	11	translation	translation	NOUN
admet-2043	761	12	,	,	PUNCT
admet-2043	761	13	increasing	increase	VERB
admet-2043	761	14	the	the	DET
admet-2043	761	15	potential	potential	NOUN
admet-2043	761	16	for	for	ADP
admet-2043	761	17	widespread	widespread	ADJ
admet-2043	761	18	adoption	adoption	NOUN
admet-2043	761	19	of	of	ADP
admet-2043	761	20	these	these	DET
admet-2043	761	21	therapies	therapy	NOUN
admet-2043	761	22	.	.	PUNCT
admet-2043	762	1	however	however	ADV
admet-2043	762	2	,	,	PUNCT
admet-2043	762	3	there	there	PRON
admet-2043	762	4	are	be	VERB
admet-2043	762	5	certain	certain	ADJ
admet-2043	762	6	disadvantages	disadvantage	NOUN
admet-2043	762	7	to	to	PART
admet-2043	762	8	consider	consider	VERB
admet-2043	762	9	[	[	PRON
admet-2043	762	10	210	210	NUM
admet-2043	762	11	]	]	PUNCT
admet-2043	762	12	.	.	PUNCT
admet-2043	763	1	meeting	meet	VERB
admet-2043	763	2	regulatory	regulatory	ADJ
admet-2043	763	3	requirements	requirement	NOUN
admet-2043	763	4	can	can	AUX
admet-2043	763	5	be	be	AUX
admet-2043	763	6	time	time	NOUN
admet-2043	763	7	-	-	PUNCT
admet-2043	763	8	consuming	consume	VERB
admet-2043	763	9	and	and	CCONJ
admet-2043	763	10	costly	costly	ADJ
admet-2043	763	11	,	,	PUNCT
admet-2043	763	12	particularly	particularly	ADV
admet-2043	763	13	for	for	ADP
admet-2043	763	14	novel	novel	ADJ
admet-2043	763	15	nanomedicine	nanomedicine	ADJ
admet-2043	763	16	products	product	NOUN
admet-2043	763	17	.	.	PUNCT
admet-2043	764	1	the	the	DET
admet-2043	764	2	evolving	evolve	VERB
admet-2043	764	3	regulatory	regulatory	ADJ
admet-2043	764	4	landscape	landscape	NOUN
admet-2043	764	5	and	and	CCONJ
admet-2043	764	6	guidelines	guideline	NOUN
admet-2043	764	7	may	may	AUX
admet-2043	764	8	introduce	introduce	VERB
admet-2043	764	9	uncertainty	uncertainty	NOUN
admet-2043	764	10	and	and	CCONJ
admet-2043	764	11	challenges	challenge	NOUN
admet-2043	764	12	during	during	ADP
admet-2043	764	13	approval	approval	NOUN
admet-2043	764	14	.	.	PUNCT
admet-2043	765	1	nonetheless	nonetheless	ADV
admet-2043	765	2	,	,	PUNCT
admet-2043	765	3	adhering	adhere	VERB
admet-2043	765	4	to	to	ADP
admet-2043	765	5	regulatory	regulatory	ADJ
admet-2043	765	6	considerations	consideration	NOUN
admet-2043	765	7	is	be	AUX
admet-2043	765	8	crucial	crucial	ADJ
admet-2043	765	9	to	to	PART
admet-2043	765	10	ensure	ensure	VERB
admet-2043	765	11	the	the	DET
admet-2043	765	12	safe	safe	ADJ
admet-2043	765	13	and	and	CCONJ
admet-2043	765	14	successful	successful	ADJ
admet-2043	765	15	development	development	NOUN
admet-2043	765	16	and	and	CCONJ
admet-2043	765	17	commercialization	commercialization	NOUN
admet-2043	765	18	of	of	ADP
admet-2043	765	19	nanomaterial	nanomaterial	NOUN
admet-2043	765	20	-	-	PUNCT
admet-2043	765	21	based	base	VERB
admet-2043	765	22	drug	drug	NOUN
admet-2043	765	23	delivery	delivery	NOUN
admet-2043	765	24	systems	system	NOUN
admet-2043	765	25	[	[	X
admet-2043	765	26	223	223	NUM
admet-2043	765	27	]	]	PUNCT
admet-2043	765	28	.	.	PUNCT
admet-2043	766	1	conclusion	conclusion	NOUN
admet-2043	766	2	significant	significant	ADJ
admet-2043	766	3	advancements	advancement	NOUN
admet-2043	766	4	have	have	AUX
admet-2043	766	5	been	be	AUX
admet-2043	766	6	made	make	VERB
admet-2043	766	7	in	in	ADP
admet-2043	766	8	targeted	target	VERB
admet-2043	766	9	and	and	CCONJ
admet-2043	766	10	personalized	personalized	ADJ
admet-2043	766	11	pharmacotherapy	pharmacotherapy	NOUN
admet-2043	766	12	,	,	PUNCT
admet-2043	766	13	with	with	ADP
admet-2043	766	14	promising	promising	ADJ
admet-2043	766	15	potential	potential	NOUN
admet-2043	766	16	in	in	ADP
admet-2043	766	17	utilizing	utilize	VERB
admet-2043	766	18	nanotechnology	nanotechnology	NOUN
admet-2043	766	19	-	-	PUNCT
admet-2043	766	20	based	base	VERB
admet-2043	766	21	materials	material	NOUN
admet-2043	766	22	and	and	CCONJ
admet-2043	766	23	devices	device	NOUN
admet-2043	766	24	.	.	PUNCT
admet-2043	767	1	the	the	DET
admet-2043	767	2	development	development	NOUN
admet-2043	767	3	of	of	ADP
admet-2043	767	4	nanoscale	nanoscale	NOUN
admet-2043	767	5	platforms	platform	NOUN
admet-2043	767	6	for	for	ADP
admet-2043	767	7	cns	cns	NOUN
admet-2043	767	8	disorders	disorder	NOUN
admet-2043	767	9	presents	present	VERB
admet-2043	767	10	a	a	DET
admet-2043	767	11	particularly	particularly	ADV
admet-2043	767	12	challenging	challenging	ADJ
admet-2043	767	13	and	and	CCONJ
admet-2043	767	14	intricate	intricate	ADJ
admet-2043	767	15	task	task	NOUN
admet-2043	767	16	compared	compare	VERB
admet-2043	767	17	to	to	ADP
admet-2043	767	18	traditional	traditional	ADJ
admet-2043	767	19	drug	drug	NOUN
admet-2043	767	20	delivery	delivery	NOUN
admet-2043	767	21	methods	method	NOUN
admet-2043	767	22	.	.	PUNCT
admet-2043	768	1	in	in	ADP
admet-2043	768	2	addition	addition	NOUN
admet-2043	768	3	to	to	ADP
admet-2043	768	4	the	the	DET
admet-2043	768	5	requisite	requisite	ADJ
admet-2043	768	6	criteria	criterion	NOUN
admet-2043	768	7	of	of	ADP
admet-2043	768	8	biocompatibility	biocompatibility	NOUN
admet-2043	768	9	,	,	PUNCT
admet-2043	768	10	biodegradability	biodegradability	NOUN
admet-2043	768	11	,	,	PUNCT
admet-2043	768	12	biodistribution	biodistribution	NOUN
admet-2043	768	13	,	,	PUNCT
admet-2043	768	14	precise	precise	ADJ
admet-2043	768	15	pharmacokinetics	pharmacokinetic	NOUN
admet-2043	768	16	and	and	CCONJ
admet-2043	768	17	pharmacodynamics	pharmacodynamic	NOUN
admet-2043	768	18	,	,	PUNCT
admet-2043	768	19	optimal	optimal	ADJ
admet-2043	768	20	therapeutic	therapeutic	ADJ
admet-2043	768	21	outcomes	outcome	NOUN
admet-2043	768	22	,	,	PUNCT
admet-2043	768	23	and	and	CCONJ
admet-2043	768	24	minimal	minimal	ADJ
admet-2043	768	25	adverse	adverse	ADJ
admet-2043	768	26	effects	effect	NOUN
admet-2043	768	27	,	,	PUNCT
admet-2043	768	28	a	a	DET
admet-2043	768	29	nanostructured	nanostructure	VERB
admet-2043	768	30	or	or	CCONJ
admet-2043	768	31	nanoscale	nanoscale	NOUN
admet-2043	768	32	platform	platform	NOUN
admet-2043	768	33	designed	design	VERB
admet-2043	768	34	for	for	ADP
admet-2043	768	35	cns	cns	NOUN
admet-2043	768	36	therapy	therapy	NOUN
admet-2043	768	37	must	must	AUX
admet-2043	768	38	account	account	VERB
admet-2043	768	39	for	for	ADP
admet-2043	768	40	the	the	DET
admet-2043	768	41	distinctive	distinctive	ADJ
admet-2043	768	42	attributes	attribute	NOUN
admet-2043	768	43	of	of	ADP
admet-2043	768	44	brain	brain	NOUN
admet-2043	768	45	tissue	tissue	NOUN
admet-2043	768	46	.	.	PUNCT
admet-2043	769	1	the	the	DET
admet-2043	769	2	advancements	advancement	NOUN
admet-2043	769	3	in	in	ADP
admet-2043	769	4	molecular	molecular	ADJ
admet-2043	769	5	and	and	CCONJ
admet-2043	769	6	cellular	cellular	ADJ
admet-2043	769	7	biology	biology	NOUN
admet-2043	769	8	,	,	PUNCT
admet-2043	769	9	as	as	ADV
admet-2043	769	10	well	well	ADV
admet-2043	769	11	as	as	ADP
admet-2043	769	12	modern	modern	ADJ
admet-2043	769	13	biomedicine	biomedicine	NOUN
admet-2043	769	14	,	,	PUNCT
admet-2043	769	15	have	have	AUX
admet-2043	769	16	provided	provide	VERB
admet-2043	769	17	researchers	researcher	NOUN
admet-2043	769	18	with	with	ADP
admet-2043	769	19	a	a	DET
admet-2043	769	20	comprehensive	comprehensive	ADJ
admet-2043	769	21	understanding	understanding	NOUN
admet-2043	769	22	of	of	ADP
admet-2043	769	23	the	the	DET
admet-2043	769	24	intrinsic	intrinsic	ADJ
admet-2043	769	25	barriers	barrier	NOUN
admet-2043	769	26	present	present	ADJ
admet-2043	769	27	in	in	ADP
admet-2043	769	28	the	the	DET
admet-2043	769	29	cns	cns	NOUN
admet-2043	769	30	,	,	PUNCT
admet-2043	769	31	specifically	specifically	ADV
admet-2043	769	32	focusing	focus	VERB
admet-2043	769	33	on	on	ADP
admet-2043	769	34	the	the	DET
admet-2043	769	35	bbb	bbb	PROPN
admet-2043	769	36	.	.	PUNCT
admet-2043	770	1	these	these	DET
admet-2043	770	2	barriers	barrier	NOUN
admet-2043	770	3	serve	serve	VERB
admet-2043	770	4	as	as	ADP
admet-2043	770	5	natural	natural	ADJ
admet-2043	770	6	protective	protective	ADJ
admet-2043	770	7	structures	structure	NOUN
admet-2043	770	8	in	in	ADP
admet-2043	770	9	the	the	DET
admet-2043	770	10	human	human	ADJ
admet-2043	770	11	brain	brain	NOUN
admet-2043	770	12	,	,	PUNCT
admet-2043	770	13	safeguarding	safeguard	VERB
admet-2043	770	14	it	it	PRON
admet-2043	770	15	against	against	ADP
admet-2043	770	16	exogenous	exogenous	ADJ
admet-2043	770	17	and	and	CCONJ
admet-2043	770	18	endogenous	endogenous	ADJ
admet-2043	770	19	molecules	molecule	NOUN
admet-2043	770	20	,	,	PUNCT
admet-2043	770	21	including	include	VERB
admet-2043	770	22	antigenic	antigenic	ADJ
admet-2043	770	23	and	and	CCONJ
admet-2043	770	24	therapeutic	therapeutic	ADJ
admet-2043	770	25	substances	substance	NOUN
admet-2043	770	26	.	.	PUNCT
admet-2043	771	1	the	the	DET
admet-2043	771	2	potential	potential	NOUN
admet-2043	771	3	of	of	ADP
admet-2043	771	4	utilizing	utilize	VERB
admet-2043	771	5	this	this	DET
admet-2043	771	6	technological	technological	ADJ
admet-2043	771	7	modality	modality	NOUN
admet-2043	771	8	for	for	ADP
admet-2043	771	9	the	the	DET
admet-2043	771	10	management	management	NOUN
admet-2043	771	11	and	and	CCONJ
admet-2043	771	12	detection	detection	NOUN
admet-2043	771	13	of	of	ADP
admet-2043	771	14	cns	cns	PROPN
admet-2043	771	15	pathologies	pathology	NOUN
admet-2043	771	16	has	have	AUX
admet-2043	771	17	been	be	AUX
admet-2043	771	18	a	a	DET
admet-2043	771	19	source	source	NOUN
admet-2043	771	20	of	of	ADP
admet-2043	771	21	optimism	optimism	NOUN
admet-2043	771	22	.	.	PUNCT
admet-2043	772	1	polymer	polymer	NOUN
admet-2043	772	2	-	-	PUNCT
admet-2043	772	3	based	base	VERB
admet-2043	772	4	techniques	technique	NOUN
admet-2043	772	5	and	and	CCONJ
admet-2043	772	6	nms	nms	NOUN
admet-2043	772	7	are	be	AUX
admet-2043	772	8	currently	currently	ADV
admet-2043	772	9	under	under	ADP
admet-2043	772	10	investigation	investigation	NOUN
admet-2043	772	11	for	for	ADP
admet-2043	772	12	the	the	DET
admet-2043	772	13	development	development	NOUN
admet-2043	772	14	of	of	ADP
admet-2043	772	15	various	various	ADJ
admet-2043	772	16	nano	nano	NOUN
admet-2043	772	17	solutions	solution	NOUN
admet-2043	772	18	aimed	aim	VERB
admet-2043	772	19	at	at	ADP
admet-2043	772	20	enhancing	enhance	VERB
admet-2043	772	21	drug	drug	NOUN
admet-2043	772	22	delivery	delivery	NOUN
admet-2043	772	23	to	to	ADP
admet-2043	772	24	patients	patient	NOUN
admet-2043	772	25	suffering	suffer	VERB
admet-2043	772	26	from	from	ADP
admet-2043	772	27	central	central	ADJ
admet-2043	772	28	nervous	nervous	ADJ
admet-2043	772	29	system	system	NOUN
admet-2043	772	30	disorders	disorder	NOUN
admet-2043	772	31	.	.	PUNCT
admet-2043	773	1	in	in	ADP
admet-2043	773	2	order	order	NOUN
admet-2043	773	3	to	to	PART
admet-2043	773	4	expedite	expedite	VERB
admet-2043	773	5	the	the	DET
admet-2043	773	6	treatment	treatment	NOUN
admet-2043	773	7	of	of	ADP
admet-2043	773	8	central	central	ADJ
admet-2043	773	9	nervous	nervous	ADJ
admet-2043	773	10	system	system	NOUN
admet-2043	773	11	-	-	PUNCT
admet-2043	773	12	related	relate	VERB
admet-2043	773	13	ailments	ailment	NOUN
admet-2043	773	14	and	and	CCONJ
admet-2043	773	15	promote	promote	VERB
admet-2043	773	16	progress	progress	NOUN
admet-2043	773	17	in	in	ADP
admet-2043	773	18	this	this	DET
admet-2043	773	19	field	field	NOUN
admet-2043	773	20	,	,	PUNCT
admet-2043	773	21	a	a	DET
admet-2043	773	22	comprehensive	comprehensive	ADJ
admet-2043	773	23	understanding	understanding	NOUN
admet-2043	773	24	of	of	ADP
admet-2043	773	25	various	various	ADJ
admet-2043	773	26	biomedical	biomedical	ADJ
admet-2043	773	27	disciplines	discipline	NOUN
admet-2043	773	28	such	such	ADJ
admet-2043	773	29	as	as	ADP
admet-2043	773	30	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	773	31	m.	m.	NOUN
admet-2043	773	32	kulkarni	kulkarni	PROPN
admet-2043	773	33	et	et	PROPN
admet-2043	773	34	al	al	PROPN
admet-2043	773	35	.	.	PROPN
admet-2043	773	36	admet	admet	PROPN
admet-2043	773	37	&	&	CCONJ
admet-2043	773	38	dmpk	dmpk	PROPN
admet-2043	773	39	12(1	12(1	PROPN
admet-2043	773	40	)	)	PUNCT
admet-2043	773	41	(	(	PUNCT
admet-2043	773	42	2024	2024	NUM
admet-2043	773	43	)	)	PUNCT
admet-2043	773	44	63	63	NUM
admet-2043	773	45	-	-	SYM
admet-2043	773	46	105	105	NUM
admet-2043	773	47	92	92	NUM
admet-2043	773	48	neuroscience	neuroscience	NOUN
admet-2043	773	49	,	,	PUNCT
admet-2043	773	50	immunology	immunology	NOUN
admet-2043	773	51	,	,	PUNCT
admet-2043	773	52	pharmacology	pharmacology	NOUN
admet-2043	773	53	,	,	PUNCT
admet-2043	773	54	and	and	CCONJ
admet-2043	773	55	molecular	molecular	ADJ
admet-2043	773	56	imaging	imaging	NOUN
admet-2043	773	57	,	,	PUNCT
admet-2043	773	58	as	as	ADV
admet-2043	773	59	well	well	ADV
admet-2043	773	60	as	as	ADP
admet-2043	773	61	materials	material	NOUN
admet-2043	773	62	science	science	NOUN
admet-2043	773	63	,	,	PUNCT
admet-2043	773	64	biomaterials	biomaterial	NOUN
admet-2043	773	65	,	,	PUNCT
admet-2043	773	66	and	and	CCONJ
admet-2043	773	67	pharmaceuticals	pharmaceutical	NOUN
admet-2043	773	68	,	,	PUNCT
admet-2043	773	69	including	include	VERB
admet-2043	773	70	polymers	polymer	NOUN
admet-2043	773	71	,	,	PUNCT
admet-2043	773	72	nanomaterials	nanomaterial	NOUN
admet-2043	773	73	,	,	PUNCT
admet-2043	773	74	drug	drug	NOUN
admet-2043	773	75	,	,	PUNCT
admet-2043	773	76	and	and	CCONJ
admet-2043	773	77	genetics	genetic	NOUN
admet-2043	773	78	,	,	PUNCT
admet-2043	773	79	is	be	AUX
admet-2043	773	80	essential	essential	ADJ
admet-2043	773	81	.	.	PUNCT
admet-2043	774	1	ethics	ethic	NOUN
admet-2043	774	2	approval	approval	NOUN
admet-2043	774	3	and	and	CCONJ
admet-2043	774	4	consent	consent	NOUN
admet-2043	774	5	to	to	PART
admet-2043	774	6	participate	participate	VERB
admet-2043	774	7	:	:	PUNCT
admet-2043	774	8	not	not	PART
admet-2043	774	9	applicable	applicable	ADJ
admet-2043	774	10	.	.	PUNCT
admet-2043	775	1	consent	consent	NOUN
admet-2043	775	2	for	for	ADP
admet-2043	775	3	publication	publication	NOUN
admet-2043	775	4	:	:	PUNCT
admet-2043	775	5	all	all	DET
admet-2043	775	6	authors	author	NOUN
admet-2043	775	7	agree	agree	VERB
admet-2043	775	8	to	to	PART
admet-2043	775	9	publish	publish	VERB
admet-2043	775	10	the	the	DET
admet-2043	775	11	manuscript	manuscript	NOUN
admet-2043	775	12	.	.	PUNCT
admet-2043	776	1	availability	availability	NOUN
admet-2043	776	2	of	of	ADP
admet-2043	776	3	data	datum	NOUN
admet-2043	776	4	and	and	CCONJ
admet-2043	776	5	material	material	NOUN
admet-2043	776	6	:	:	PUNCT
admet-2043	776	7	not	not	PART
admet-2043	776	8	applicable	applicable	ADJ
admet-2043	776	9	.	.	PUNCT
admet-2043	777	1	conflict	conflict	NOUN
admet-2043	777	2	of	of	ADP
admet-2043	777	3	interests	interest	NOUN
admet-2043	777	4	:	:	PUNCT
admet-2043	777	5	there	there	PRON
admet-2043	777	6	is	be	VERB
admet-2043	777	7	no	no	DET
admet-2043	777	8	conflict	conflict	NOUN
admet-2043	777	9	of	of	ADP
admet-2043	777	10	interest	interest	NOUN
admet-2043	777	11	or	or	CCONJ
admet-2043	777	12	objection	objection	NOUN
admet-2043	777	13	from	from	ADP
admet-2043	777	14	the	the	DET
admet-2043	777	15	side	side	NOUN
admet-2043	777	16	of	of	ADP
admet-2043	777	17	the	the	DET
admet-2043	777	18	authors	author	NOUN
admet-2043	777	19	.	.	PUNCT
admet-2043	778	1	author	author	NOUN
admet-2043	778	2	contribution	contribution	PROPN
admet-2043	778	3	:	:	PUNCT
admet-2043	778	4	swayamprakash	swayamprakash	PROPN
admet-2043	778	5	patel	patel	NOUN
admet-2043	778	6	:	:	PUNCT
admet-2043	778	7	conceptualization	conceptualization	NOUN
admet-2043	778	8	and	and	CCONJ
admet-2043	778	9	writing	write	VERB
admet-2043	778	10	review	review	NOUN
admet-2043	778	11	and	and	CCONJ
admet-2043	778	12	editing	edit	VERB
admet-2043	778	13	ayush	ayush	ADJ
admet-2043	778	14	patel	patel	NOUN
admet-2043	778	15	and	and	CCONJ
admet-2043	778	16	krishi	krishi	PROPN
admet-2043	778	17	patel	patel	PROPN
admet-2043	778	18	:	:	PUNCT
admet-2043	778	19	writing	write	VERB
admet-2043	778	20	manuscript	manuscript	NOUN
admet-2043	778	21	–	–	PUNCT
admet-2043	778	22	original	original	ADJ
admet-2043	778	23	draft	draft	NOUN
admet-2043	778	24	mehul	mehul	NOUN
admet-2043	778	25	patel	patel	PROPN
admet-2043	778	26	,	,	PUNCT
admet-2043	778	27	umang	umang	PROPN
admet-2043	778	28	shah	shah	PROPN
admet-2043	778	29	,	,	PUNCT
admet-2043	778	30	ashish	ashish	PROPN
admet-2043	778	31	patel	patel	PROPN
admet-2043	778	32	:	:	PUNCT
admet-2043	778	33	supervision	supervision	NOUN
admet-2043	778	34	on	on	ADP
admet-2043	778	35	bbb	bbb	PROPN
admet-2043	778	36	and	and	CCONJ
admet-2043	778	37	nano	nano	PROPN
admet-2043	778	38	materials	material	NOUN
admet-2043	778	39	mangesh	mangesh	PROPN
admet-2043	778	40	kulkarni	kulkarni	NOUN
admet-2043	778	41	:	:	PUNCT
admet-2043	778	42	investigation	investigation	NOUN
admet-2043	778	43	and	and	CCONJ
admet-2043	778	44	resources	resource	NOUN
admet-2043	778	45	jagruti	jagruti	PROPN
admet-2043	778	46	desai	desai	PROPN
admet-2043	778	47	and	and	CCONJ
admet-2043	778	48	nilay	nilay	VERB
admet-2043	778	49	solanki	solanki	PROPN
admet-2043	778	50	:	:	PUNCT
admet-2043	778	51	validation	validation	NOUN
admet-2043	778	52	and	and	CCONJ
admet-2043	778	53	formal	formal	ADJ
admet-2043	778	54	analysis	analysis	NOUN
admet-2043	778	55	references	reference	NOUN
admet-2043	778	56	[	[	X
admet-2043	778	57	1	1	NUM
admet-2043	778	58	]	]	PUNCT
admet-2043	778	59	m.	m.	NOUN
admet-2043	778	60	bentivoglio	bentivoglio	PROPN
admet-2043	778	61	,	,	PUNCT
admet-2043	778	62	k.	k.	PROPN
admet-2043	778	63	kristensson	kristensson	PROPN
admet-2043	778	64	.	.	PUNCT
admet-2043	779	1	tryps	tryp	NOUN
admet-2043	779	2	and	and	CCONJ
admet-2043	779	3	trips	trip	NOUN
admet-2043	779	4	:	:	PUNCT
admet-2043	779	5	cell	cell	NOUN
admet-2043	779	6	trafficking	trafficking	NOUN
admet-2043	779	7	across	across	ADP
admet-2043	779	8	the	the	DET
admet-2043	779	9	100	100	NUM
admet-2043	779	10	-	-	PUNCT
admet-2043	779	11	year	year	NOUN
admet-2043	779	12	-	-	PUNCT
admet-2043	779	13	old	old	ADJ
admet-2043	779	14	blood	blood	NOUN
admet-2043	779	15	-	-	PUNCT
admet-2043	779	16	brain	brain	NOUN
admet-2043	779	17	barrier	barrier	NOUN
admet-2043	779	18	.	.	PUNCT
admet-2043	780	1	trends	trend	NOUN
admet-2043	780	2	in	in	ADP
admet-2043	780	3	neurosciences	neuroscience	NOUN
admet-2043	780	4	37	37	NUM
admet-2043	780	5	(	(	PUNCT
admet-2043	780	6	2014	2014	NUM
admet-2043	780	7	)	)	PUNCT
admet-2043	780	8	325	325	NUM
admet-2043	780	9	-	-	SYM
admet-2043	780	10	333	333	NUM
admet-2043	780	11	.	.	PUNCT
admet-2043	781	1	https://doi.org/10.1016/j.tins.2014.03.007	https://doi.org/10.1016/j.tins.2014.03.007	NOUN
admet-2043	781	2	.	.	PUNCT
admet-2043	782	1	[	[	X
admet-2043	782	2	2	2	NUM
admet-2043	782	3	]	]	PUNCT
admet-2043	782	4	r.	r.	PROPN
admet-2043	782	5	daneman	daneman	PROPN
admet-2043	782	6	,	,	PUNCT
admet-2043	782	7	a.	a.	NOUN
admet-2043	782	8	prat	prat	NOUN
admet-2043	782	9	.	.	PUNCT
admet-2043	783	1	the	the	DET
admet-2043	783	2	blood	blood	NOUN
admet-2043	783	3	-	-	PUNCT
admet-2043	783	4	brain	brain	NOUN
admet-2043	783	5	barrier	barrier	NOUN
admet-2043	783	6	.	.	PUNCT
admet-2043	784	1	cold	cold	ADJ
admet-2043	784	2	spring	spring	NOUN
admet-2043	784	3	harbor	harbor	NOUN
admet-2043	784	4	perspectives	perspective	NOUN
admet-2043	784	5	in	in	ADP
admet-2043	784	6	biology	biology	NOUN
admet-2043	784	7	7	7	NUM
admet-2043	784	8	(	(	PUNCT
admet-2043	784	9	2015	2015	NUM
admet-2043	784	10	)	)	PUNCT
admet-2043	784	11	a020412	a020412	NOUN
admet-2043	784	12	.	.	PUNCT
admet-2043	785	1	https://doi.org/10.1101/cshperspect.a020412	https://doi.org/10.1101/cshperspect.a020412	INTJ
admet-2043	785	2	.	.	PUNCT
admet-2043	786	1	[	[	X
admet-2043	786	2	3	3	X
admet-2043	786	3	]	]	X
admet-2043	786	4	c.m	c.m	PROPN
admet-2043	786	5	.	.	PROPN
admet-2043	786	6	peppiatt	peppiatt	PROPN
admet-2043	786	7	,	,	PUNCT
admet-2043	786	8	c.	c.	PROPN
admet-2043	786	9	howarth	howarth	PROPN
admet-2043	786	10	,	,	PUNCT
admet-2043	786	11	p.	p.	NOUN
admet-2043	786	12	mobbs	mobbs	PROPN
admet-2043	786	13	,	,	PUNCT
admet-2043	786	14	d.	d.	PROPN
admet-2043	786	15	attwell	attwell	PROPN
admet-2043	786	16	.	.	PUNCT
admet-2043	787	1	bidirectional	bidirectional	ADJ
admet-2043	787	2	control	control	NOUN
admet-2043	787	3	of	of	ADP
admet-2043	787	4	cns	cns	PROPN
admet-2043	787	5	capillary	capillary	ADJ
admet-2043	787	6	diameter	diameter	NOUN
admet-2043	787	7	by	by	ADP
admet-2043	787	8	pericytes	pericyte	NOUN
admet-2043	787	9	.	.	PUNCT
admet-2043	788	1	nature	nature	NOUN
admet-2043	788	2	443	443	NUM
admet-2043	788	3	(	(	PUNCT
admet-2043	788	4	2006	2006	NUM
admet-2043	788	5	)	)	PUNCT
admet-2043	788	6	700	700	NUM
admet-2043	788	7	-	-	SYM
admet-2043	788	8	704	704	NUM
admet-2043	788	9	.	.	PUNCT
admet-2043	788	10	https://doi.org/10.1038/nature05193	https://doi.org/10.1038/nature05193	PROPN
admet-2043	788	11	.	.	PUNCT
admet-2043	789	1	[	[	X
admet-2043	789	2	4	4	X
admet-2043	789	3	]	]	PUNCT
admet-2043	789	4	l.	l.	PROPN
admet-2043	789	5	gonzalez	gonzalez	PROPN
admet-2043	789	6	-	-	PUNCT
admet-2043	789	7	mariscal	mariscal	PROPN
admet-2043	789	8	,	,	PUNCT
admet-2043	789	9	r.	r.	PROPN
admet-2043	789	10	tapia	tapia	PROPN
admet-2043	789	11	,	,	PUNCT
admet-2043	789	12	d.	d.	PROPN
admet-2043	789	13	chamorro	chamorro	PROPN
admet-2043	789	14	.	.	PROPN
admet-2043	789	15	crosstalk	crosstalk	NOUN
admet-2043	789	16	of	of	ADP
admet-2043	789	17	tight	tight	ADJ
admet-2043	789	18	junction	junction	NOUN
admet-2043	789	19	components	component	NOUN
admet-2043	789	20	with	with	ADP
admet-2043	789	21	signaling	signal	VERB
admet-2043	789	22	pathways	pathway	NOUN
admet-2043	789	23	.	.	PUNCT
admet-2043	790	1	biochimica	biochimica	PROPN
admet-2043	790	2	et	et	PROPN
admet-2043	790	3	biophysica	biophysica	PROPN
admet-2043	790	4	acta	acta	PROPN
admet-2043	790	5	1778	1778	NUM
admet-2043	790	6	(	(	PUNCT
admet-2043	790	7	2008	2008	NUM
admet-2043	790	8	)	)	PUNCT
admet-2043	790	9	729	729	NUM
admet-2043	790	10	-	-	SYM
admet-2043	790	11	756	756	NUM
admet-2043	790	12	.	.	PUNCT
admet-2043	791	1	https://doi.org/10.1016/j.bbamem.2007.08.018	https://doi.org/10.1016/j.bbamem.2007.08.018	NOUN
admet-2043	791	2	.	.	PUNCT
admet-2043	792	1	[	[	X
admet-2043	792	2	5	5	X
admet-2043	792	3	]	]	PUNCT
admet-2043	792	4	y.	y.	PROPN
admet-2043	792	5	zhou	zhou	PROPN
admet-2043	792	6	,	,	PUNCT
admet-2043	792	7	z.	z.	PROPN
admet-2043	792	8	peng	peng	PROPN
admet-2043	792	9	,	,	PUNCT
admet-2043	792	10	e.s	e.s	PROPN
admet-2043	792	11	.	.	PROPN
admet-2043	792	12	seven	seven	NUM
admet-2043	792	13	,	,	PUNCT
admet-2043	792	14	r.m	r.m	PROPN
admet-2043	792	15	.	.	PROPN
admet-2043	792	16	leblanc	leblanc	PROPN
admet-2043	792	17	.	.	PROPN
admet-2043	792	18	crossing	cross	VERB
admet-2043	792	19	the	the	DET
admet-2043	792	20	blood	blood	NOUN
admet-2043	792	21	-	-	PUNCT
admet-2043	792	22	brain	brain	NOUN
admet-2043	792	23	barrier	barrier	NOUN
admet-2043	792	24	with	with	ADP
admet-2043	792	25	nanoparticles	nanoparticle	NOUN
admet-2043	792	26	.	.	PUNCT
admet-2043	793	1	journal	journal	NOUN
admet-2043	793	2	of	of	ADP
admet-2043	793	3	controlled	control	VERB
admet-2043	793	4	release	release	NOUN
admet-2043	793	5	270	270	NUM
admet-2043	793	6	(	(	PUNCT
admet-2043	793	7	2018	2018	NUM
admet-2043	793	8	)	)	PUNCT
admet-2043	793	9	290	290	NUM
admet-2043	793	10	-	-	SYM
admet-2043	793	11	303	303	NUM
admet-2043	793	12	.	.	PUNCT
admet-2043	794	1	https://doi.org/10.1016/j.jconrel.2017.12.015	https://doi.org/10.1016/j.jconrel.2017.12.015	NOUN
admet-2043	794	2	.	.	PUNCT
admet-2043	795	1	[	[	X
admet-2043	795	2	6	6	NUM
admet-2043	795	3	]	]	PUNCT
admet-2043	795	4	m.	m.	NOUN
admet-2043	795	5	habgood	habgood	PROPN
admet-2043	795	6	,	,	PUNCT
admet-2043	795	7	j.	j.	PROPN
admet-2043	795	8	ek	ek	PROPN
admet-2043	795	9	.	.	PUNCT
admet-2043	795	10	delivering	deliver	VERB
admet-2043	795	11	drugs	drug	NOUN
admet-2043	795	12	into	into	ADP
admet-2043	795	13	the	the	DET
admet-2043	795	14	brain	brain	NOUN
admet-2043	795	15	:	:	PUNCT
admet-2043	795	16	barriers	barrier	NOUN
admet-2043	795	17	and	and	CCONJ
admet-2043	795	18	possibilities	possibility	NOUN
admet-2043	795	19	.	.	PUNCT
admet-2043	796	1	therapeutic	therapeutic	ADJ
admet-2043	796	2	delivery	delivery	NOUN
admet-2043	796	3	1	1	NUM
admet-2043	796	4	(	(	PUNCT
admet-2043	796	5	2010	2010	NUM
admet-2043	796	6	)	)	PUNCT
admet-2043	796	7	483	483	NUM
admet-2043	796	8	-	-	SYM
admet-2043	796	9	488	488	NUM
admet-2043	796	10	.	.	PUNCT
admet-2043	796	11	https://doi.org/10.4155/tde.10.58	https://doi.org/10.4155/tde.10.58	NOUN
admet-2043	796	12	.	.	PUNCT
admet-2043	797	1	[	[	X
admet-2043	797	2	7	7	X
admet-2043	797	3	]	]	X
admet-2043	797	4	m.	m.	NOUN
admet-2043	797	5	kumar	kumar	PROPN
admet-2043	797	6	,	,	PUNCT
admet-2043	797	7	p.	p.	PROPN
admet-2043	797	8	sharma	sharma	PROPN
admet-2043	797	9	,	,	PUNCT
admet-2043	797	10	r.	r.	PROPN
admet-2043	797	11	maheshwari	maheshwari	PROPN
admet-2043	797	12	,	,	PUNCT
admet-2043	797	13	m.	m.	NOUN
admet-2043	797	14	tekade	tekade	PROPN
admet-2043	797	15	,	,	PUNCT
admet-2043	797	16	s.k	s.k	PROPN
admet-2043	797	17	.	.	PROPN
admet-2043	797	18	shrivastava	shrivastava	PROPN
admet-2043	797	19	,	,	PUNCT
admet-2043	797	20	r.k	r.k	PROPN
admet-2043	797	21	.	.	PROPN
admet-2043	797	22	tekade	tekade	PROPN
admet-2043	797	23	,	,	PUNCT
admet-2043	797	24	beyond	beyond	ADP
admet-2043	797	25	the	the	DET
admet-2043	797	26	blood	blood	NOUN
admet-2043	797	27	–	–	PUNCT
admet-2043	797	28	brain	brain	NOUN
admet-2043	797	29	barrier	barrier	NOUN
admet-2043	797	30	,	,	PUNCT
admet-2043	797	31	in	in	ADP
admet-2043	797	32	nanotechnology	nanotechnology	NOUN
admet-2043	797	33	-	-	PUNCT
admet-2043	797	34	based	base	VERB
admet-2043	797	35	targeted	target	VERB
admet-2043	797	36	drug	drug	NOUN
admet-2043	797	37	delivery	delivery	NOUN
admet-2043	797	38	systems	system	NOUN
admet-2043	797	39	for	for	ADP
admet-2043	797	40	brain	brain	NOUN
admet-2043	797	41	tumors	tumor	NOUN
admet-2043	797	42	,	,	PUNCT
admet-2043	797	43	elsevier	elsevier	NOUN
admet-2043	797	44	,	,	PUNCT
admet-2043	797	45	amsterdam	amsterdam	PROPN
admet-2043	797	46	,	,	PUNCT
admet-2043	797	47	netherlands	netherlands	PROPN
admet-2043	797	48	,	,	PUNCT
admet-2043	797	49	2018	2018	NUM
admet-2043	797	50	,	,	PUNCT
admet-2043	797	51	p.	p.	NOUN
admet-2043	797	52	397	397	NUM
admet-2043	797	53	-	-	SYM
admet-2043	797	54	437	437	NUM
admet-2043	797	55	9780128122181	9780128122181	NUM
admet-2043	797	56	.	.	PUNCT
admet-2043	798	1	https://doi.org/10.1016/b978-0-12-812218-1.00015-4	https://doi.org/10.1016/b978-0-12-812218-1.00015-4	NOUN
admet-2043	798	2	.	.	PUNCT
admet-2043	799	1	[	[	X
admet-2043	799	2	8	8	NUM
admet-2043	799	3	]	]	X
admet-2043	799	4	k.l	k.l	PROPN
admet-2043	799	5	.	.	PROPN
admet-2043	799	6	chaichana	chaichana	PROPN
admet-2043	799	7	,	,	PUNCT
admet-2043	799	8	l.	l.	PROPN
admet-2043	799	9	pinheiro	pinheiro	PROPN
admet-2043	799	10	,	,	PUNCT
admet-2043	799	11	h.	h.	PROPN
admet-2043	799	12	brem	brem	PROPN
admet-2043	799	13	.	.	PUNCT
admet-2043	800	1	delivery	delivery	NOUN
admet-2043	800	2	of	of	ADP
admet-2043	800	3	local	local	ADJ
admet-2043	800	4	therapeutics	therapeutic	NOUN
admet-2043	800	5	to	to	ADP
admet-2043	800	6	the	the	DET
admet-2043	800	7	brain	brain	NOUN
admet-2043	800	8	:	:	PUNCT
admet-2043	800	9	working	work	VERB
admet-2043	800	10	toward	toward	ADP
admet-2043	800	11	advancing	advance	VERB
admet-2043	800	12	treatment	treatment	NOUN
admet-2043	800	13	for	for	ADP
admet-2043	800	14	malignant	malignant	ADJ
admet-2043	800	15	gliomas	glioma	NOUN
admet-2043	800	16	.	.	PUNCT
admet-2043	801	1	therapeutic	therapeutic	ADJ
admet-2043	801	2	delivery	delivery	NOUN
admet-2043	801	3	6	6	NUM
admet-2043	801	4	(	(	PUNCT
admet-2043	801	5	2015	2015	NUM
admet-2043	801	6	)	)	PUNCT
admet-2043	801	7	353	353	NUM
admet-2043	801	8	-	-	SYM
admet-2043	801	9	369	369	NUM
admet-2043	801	10	.	.	PUNCT
admet-2043	802	1	https://doi.org/10.4155/tde.14.114	https://doi.org/10.4155/tde.14.114	NOUN
admet-2043	802	2	.	.	PUNCT
admet-2043	803	1	[	[	X
admet-2043	803	2	9	9	X
admet-2043	803	3	]	]	X
admet-2043	803	4	v.	v.	CCONJ
admet-2043	803	5	bourganis	bourganis	PROPN
admet-2043	803	6	,	,	PUNCT
admet-2043	803	7	o.	o.	PROPN
admet-2043	803	8	kammona	kammona	PROPN
admet-2043	803	9	,	,	PUNCT
admet-2043	803	10	a.	a.	NOUN
admet-2043	803	11	alexopoulos	alexopoulos	PROPN
admet-2043	803	12	,	,	PUNCT
admet-2043	803	13	c.	c.	PROPN
admet-2043	803	14	kiparissides	kiparisside	NOUN
admet-2043	803	15	.	.	PUNCT
admet-2043	804	1	recent	recent	ADJ
admet-2043	804	2	advances	advance	NOUN
admet-2043	804	3	in	in	ADP
admet-2043	804	4	carrier	carrier	NOUN
admet-2043	804	5	mediated	mediate	VERB
admet-2043	804	6	nose	nose	NOUN
admet-2043	804	7	-	-	PUNCT
admet-2043	804	8	to	to	ADP
admet-2043	804	9	-	-	PUNCT
admet-2043	804	10	brain	brain	NOUN
admet-2043	804	11	delivery	delivery	NOUN
admet-2043	804	12	of	of	ADP
admet-2043	804	13	pharmaceutics	pharmaceutic	NOUN
admet-2043	804	14	.	.	PUNCT
admet-2043	805	1	european	european	ADJ
admet-2043	805	2	journal	journal	PROPN
admet-2043	805	3	of	of	ADP
admet-2043	805	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	805	5	and	and	CCONJ
admet-2043	805	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2043	805	7	128	128	NUM
admet-2043	805	8	(	(	PUNCT
admet-2043	805	9	2018	2018	NUM
admet-2043	805	10	)	)	PUNCT
admet-2043	805	11	337	337	NUM
admet-2043	805	12	-	-	SYM
admet-2043	805	13	362	362	NUM
admet-2043	805	14	.	.	PUNCT
admet-2043	806	1	https://doi.org/10.1016/j.ejpb.2018.05.009	https://doi.org/10.1016/j.ejpb.2018.05.009	NOUN
admet-2043	806	2	.	.	PUNCT
admet-2043	807	1	[	[	X
admet-2043	807	2	10	10	NUM
admet-2043	807	3	]	]	X
admet-2043	807	4	j.j	j.j	PROPN
admet-2043	807	5	.	.	PROPN
admet-2043	807	6	lochhead	lochhead	PROPN
admet-2043	807	7	,	,	PUNCT
admet-2043	807	8	r.g	r.g	PROPN
admet-2043	807	9	.	.	PROPN
admet-2043	807	10	thorne	thorne	PROPN
admet-2043	807	11	.	.	PUNCT
admet-2043	808	1	intranasal	intranasal	ADJ
admet-2043	808	2	delivery	delivery	NOUN
admet-2043	808	3	of	of	ADP
admet-2043	808	4	biologics	biologic	NOUN
admet-2043	808	5	to	to	ADP
admet-2043	808	6	the	the	DET
admet-2043	808	7	central	central	ADJ
admet-2043	808	8	nervous	nervous	ADJ
admet-2043	808	9	system	system	NOUN
admet-2043	808	10	.	.	PUNCT
admet-2043	809	1	advanced	advanced	ADJ
admet-2043	809	2	drug	drug	NOUN
admet-2043	809	3	delivery	delivery	NOUN
admet-2043	809	4	reviews	review	VERB
admet-2043	809	5	64	64	NUM
admet-2043	809	6	(	(	PUNCT
admet-2043	809	7	2012	2012	NUM
admet-2043	809	8	)	)	PUNCT
admet-2043	809	9	614	614	NUM
admet-2043	809	10	-	-	SYM
admet-2043	809	11	628	628	NUM
admet-2043	809	12	.	.	PUNCT
admet-2043	810	1	https://doi.org/10.1016/j.addr.2011.11.002	https://doi.org/10.1016/j.addr.2011.11.002	NOUN
admet-2043	810	2	.	.	PUNCT
admet-2043	811	1	[	[	X
admet-2043	811	2	11	11	NUM
admet-2043	811	3	]	]	PUNCT
admet-2043	811	4	m.	m.	PROPN
admet-2043	811	5	blanchette	blanchette	PROPN
admet-2043	811	6	,	,	PUNCT
admet-2043	811	7	d.	d.	PROPN
admet-2043	811	8	fortin	fortin	PROPN
admet-2043	811	9	,	,	PUNCT
admet-2043	811	10	blood	blood	NOUN
admet-2043	811	11	-	-	PUNCT
admet-2043	811	12	brain	brain	NOUN
admet-2043	811	13	barrier	barrier	NOUN
admet-2043	811	14	disruption	disruption	NOUN
admet-2043	811	15	in	in	ADP
admet-2043	811	16	the	the	DET
admet-2043	811	17	treatment	treatment	NOUN
admet-2043	811	18	of	of	ADP
admet-2043	811	19	brain	brain	NOUN
admet-2043	811	20	tumors	tumor	NOUN
admet-2043	811	21	,	,	PUNCT
admet-2043	811	22	in	in	ADP
admet-2043	811	23	methods	method	NOUN
admet-2043	811	24	in	in	ADP
admet-2043	811	25	molecular	molecular	ADJ
admet-2043	811	26	biology	biology	NOUN
admet-2043	811	27	,	,	PUNCT
admet-2043	811	28	humana	humana	PROPN
admet-2043	811	29	press	press	PROPN
admet-2043	811	30	inc.2011	inc.2011	ADP
admet-2043	811	31	,	,	PUNCT
admet-2043	811	32	p.	p.	NOUN
admet-2043	811	33	447	447	NUM
admet-2043	811	34	-	-	SYM
admet-2043	811	35	463	463	NUM
admet-2043	811	36	.	.	PUNCT
admet-2043	812	1	https://doi.org/10.1007/9781-60761-938-3_23	https://doi.org/10.1007/9781-60761-938-3_23	NOUN
admet-2043	812	2	.	.	PUNCT
admet-2043	813	1	[	[	X
admet-2043	813	2	12	12	NUM
admet-2043	813	3	]	]	SYM
admet-2043	813	4	a.b	a.b	PROPN
admet-2043	813	5	.	.	PROPN
admet-2043	813	6	etame	etame	PROPN
admet-2043	813	7	,	,	PUNCT
admet-2043	813	8	r.j	r.j	PROPN
admet-2043	813	9	.	.	PROPN
admet-2043	813	10	diaz	diaz	PROPN
admet-2043	813	11	,	,	PUNCT
admet-2043	813	12	m.a	m.a	PROPN
admet-2043	813	13	.	.	PROPN
admet-2043	813	14	o'reilly	o'reilly	PROPN
admet-2043	813	15	,	,	PUNCT
admet-2043	813	16	c.a	c.a	PROPN
admet-2043	813	17	.	.	PROPN
admet-2043	813	18	smith	smith	PROPN
admet-2043	813	19	,	,	PUNCT
admet-2043	813	20	t.g	t.g	PROPN
admet-2043	813	21	.	.	PROPN
admet-2043	813	22	mainprize	mainprize	PROPN
admet-2043	813	23	,	,	PUNCT
admet-2043	813	24	k.	k.	PROPN
admet-2043	813	25	hynynen	hynynen	PROPN
admet-2043	813	26	,	,	PUNCT
admet-2043	813	27	j.t	j.t	PROPN
admet-2043	813	28	.	.	PROPN
admet-2043	813	29	rutka	rutka	PROPN
admet-2043	813	30	.	.	PUNCT
admet-2043	814	1	enhanced	enhance	VERB
admet-2043	814	2	delivery	delivery	NOUN
admet-2043	814	3	of	of	ADP
admet-2043	814	4	gold	gold	ADJ
admet-2043	814	5	nanoparticles	nanoparticle	NOUN
admet-2043	814	6	with	with	ADP
admet-2043	814	7	therapeutic	therapeutic	ADJ
admet-2043	814	8	potential	potential	NOUN
admet-2043	814	9	into	into	ADP
admet-2043	814	10	the	the	DET
admet-2043	814	11	brain	brain	NOUN
admet-2043	814	12	using	use	VERB
admet-2043	814	13	mri	mri	NOUN
admet-2043	814	14	-	-	PUNCT
admet-2043	814	15	guided	guide	VERB
admet-2043	814	16	focused	focus	VERB
admet-2043	814	17	ultrasound	ultrasound	NOUN
admet-2043	814	18	.	.	PUNCT
admet-2043	815	1	nanomedicine	nanomedicine	PROPN
admet-2043	815	2	:	:	PUNCT
admet-2043	815	3	nanotechnology	nanotechnology	NOUN
admet-2043	815	4	,	,	PUNCT
admet-2043	815	5	biology	biology	NOUN
admet-2043	815	6	,	,	PUNCT
admet-2043	815	7	and	and	CCONJ
admet-2043	815	8	medicine	medicine	NOUN
admet-2043	815	9	8	8	NUM
admet-2043	815	10	(	(	PUNCT
admet-2043	815	11	2012	2012	NUM
admet-2043	815	12	)	)	PUNCT
admet-2043	815	13	1133	1133	NUM
admet-2043	815	14	-	-	SYM
admet-2043	815	15	1142	1142	NUM
admet-2043	815	16	.	.	PUNCT
admet-2043	816	1	https://doi.org/10.1016/j.nano.2012.02.003	https://doi.org/10.1016/j.nano.2012.02.003	PROPN
admet-2043	816	2	.	.	PUNCT
admet-2043	817	1	https://doi.org/10.1016/j.tins.2014.03.007	https://doi.org/10.1016/j.tins.2014.03.007	NOUN
admet-2043	817	2	https://doi.org/10.1101/cshperspect.a020412	https://doi.org/10.1101/cshperspect.a020412	PROPN
admet-2043	817	3	https://doi.org/10.1038/nature05193	https://doi.org/10.1038/nature05193	PROPN
admet-2043	817	4	https://doi.org/10.1016/j.bbamem.2007.08.018	https://doi.org/10.1016/j.bbamem.2007.08.018	PROPN
admet-2043	817	5	https://doi.org/10.1016/j.jconrel.2017.12.015	https://doi.org/10.1016/j.jconrel.2017.12.015	PROPN
admet-2043	817	6	https://doi.org/10.4155/tde.10.58	https://doi.org/10.4155/tde.10.58	NOUN
admet-2043	817	7	https://doi.org/10.1016/b978-0-12-812218-1.00015-4	https://doi.org/10.1016/b978-0-12-812218-1.00015-4	NOUN
admet-2043	817	8	https://doi.org/10.4155/tde.14.114	https://doi.org/10.4155/tde.14.114	NOUN
admet-2043	817	9	https://doi.org/10.1016/j.ejpb.2018.05.009	https://doi.org/10.1016/j.ejpb.2018.05.009	NOUN
admet-2043	817	10	https://doi.org/10.1016/j.addr.2011.11.002	https://doi.org/10.1016/j.addr.2011.11.002	NOUN
admet-2043	817	11	https://doi.org/10.1007/978-1-60761-938-3_23	https://doi.org/10.1007/978-1-60761-938-3_23	PROPN
admet-2043	817	12	https://doi.org/10.1007/978-1-60761-938-3_23	https://doi.org/10.1007/978-1-60761-938-3_23	PROPN
admet-2043	817	13	https://doi.org/10.1016/j.nano.2012.02.003	https://doi.org/10.1016/j.nano.2012.02.003	PROPN
admet-2043	817	14	admet	admet	PROPN
admet-2043	817	15	&	&	CCONJ
admet-2043	817	16	dmpk	dmpk	PROPN
admet-2043	817	17	12(1	12(1	PROPN
admet-2043	817	18	)	)	PUNCT
admet-2043	817	19	(	(	PUNCT
admet-2043	817	20	2024	2024	NUM
admet-2043	817	21	)	)	PUNCT
admet-2043	817	22	63	63	NUM
admet-2043	817	23	-	-	SYM
admet-2043	817	24	105	105	NUM
admet-2043	817	25	nanomaterials	nanomaterial	NOUN
admet-2043	817	26	as	as	ADP
admet-2043	817	27	drug	drug	NOUN
admet-2043	817	28	delivery	delivery	NOUN
admet-2043	817	29	agents	agent	NOUN
admet-2043	817	30	for	for	ADP
admet-2043	817	31	overcoming	overcome	VERB
admet-2043	817	32	bbb	bbb	PROPN
admet-2043	817	33	doi	doi	NOUN
admet-2043	817	34	:	:	PUNCT
admet-2043	817	35	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	817	36	93	93	NUM
admet-2043	817	37	[	[	SYM
admet-2043	817	38	13	13	NUM
admet-2043	817	39	]	]	PUNCT
admet-2043	817	40	i.	i.	PROPN
admet-2043	817	41	posadas	posadas	PROPN
admet-2043	817	42	,	,	PUNCT
admet-2043	817	43	s.	s.	PROPN
admet-2043	817	44	monteagudo	monteagudo	PROPN
admet-2043	817	45	,	,	PUNCT
admet-2043	817	46	v.	v.	PROPN
admet-2043	817	47	cena	cena	PROPN
admet-2043	817	48	.	.	PUNCT
admet-2043	818	1	nanoparticles	nanoparticle	NOUN
admet-2043	818	2	for	for	ADP
admet-2043	818	3	brain	brain	NOUN
admet-2043	818	4	-	-	PUNCT
admet-2043	818	5	specific	specific	ADJ
admet-2043	818	6	drug	drug	NOUN
admet-2043	818	7	and	and	CCONJ
admet-2043	818	8	genetic	genetic	ADJ
admet-2043	818	9	material	material	NOUN
admet-2043	818	10	delivery	delivery	NOUN
admet-2043	818	11	,	,	PUNCT
admet-2043	818	12	imaging	imaging	NOUN
admet-2043	818	13	and	and	CCONJ
admet-2043	818	14	diagnosis	diagnosis	NOUN
admet-2043	818	15	.	.	PUNCT
admet-2043	819	1	nanomedicine	nanomedicine	NOUN
admet-2043	819	2	(	(	PUNCT
admet-2043	819	3	lond	lond	ADJ
admet-2043	819	4	)	)	PUNCT
admet-2043	819	5	11	11	NUM
admet-2043	819	6	(	(	PUNCT
admet-2043	819	7	2016	2016	NUM
admet-2043	819	8	)	)	PUNCT
admet-2043	819	9	833	833	NUM
admet-2043	819	10	-	-	SYM
admet-2043	819	11	849	849	NUM
admet-2043	819	12	.	.	PUNCT
admet-2043	819	13	https://doi.org/10.2217/nnm.16.15	https://doi.org/10.2217/nnm.16.15	NOUN
admet-2043	819	14	.	.	PUNCT
admet-2043	820	1	[	[	X
admet-2043	820	2	14	14	NUM
admet-2043	820	3	]	]	X
admet-2043	820	4	b.t	b.t	PROPN
admet-2043	820	5	.	.	PROPN
admet-2043	820	6	hawkins	hawkins	PROPN
admet-2043	820	7	,	,	PUNCT
admet-2043	820	8	t.p	t.p	PROPN
admet-2043	820	9	.	.	PROPN
admet-2043	820	10	davis	davis	PROPN
admet-2043	820	11	.	.	PUNCT
admet-2043	821	1	the	the	DET
admet-2043	821	2	blood	blood	NOUN
admet-2043	821	3	-	-	PUNCT
admet-2043	821	4	brain	brain	NOUN
admet-2043	821	5	barrier	barrier	NOUN
admet-2043	821	6	/	/	SYM
admet-2043	821	7	neurovascular	neurovascular	ADJ
admet-2043	821	8	unit	unit	NOUN
admet-2043	821	9	in	in	ADP
admet-2043	821	10	health	health	NOUN
admet-2043	821	11	and	and	CCONJ
admet-2043	821	12	disease	disease	NOUN
admet-2043	821	13	.	.	PUNCT
admet-2043	822	1	pharmacological	pharmacological	ADJ
admet-2043	822	2	reviews	review	NOUN
admet-2043	822	3	57	57	NUM
admet-2043	822	4	(	(	PUNCT
admet-2043	822	5	2005	2005	NUM
admet-2043	822	6	)	)	PUNCT
admet-2043	822	7	173	173	NUM
admet-2043	822	8	-	-	SYM
admet-2043	822	9	185	185	NUM
admet-2043	822	10	.	.	PUNCT
admet-2043	823	1	https://doi.org/10.1124/pr.57.2.4	https://doi.org/10.1124/pr.57.2.4	X
admet-2043	823	2	.	.	PUNCT
admet-2043	824	1	[	[	X
admet-2043	824	2	15	15	NUM
admet-2043	824	3	]	]	X
admet-2043	824	4	y.	y.	PROPN
admet-2043	824	5	takakura	takakura	PROPN
admet-2043	824	6	,	,	PUNCT
admet-2043	824	7	k.l	k.l	PROPN
admet-2043	824	8	.	.	PROPN
admet-2043	824	9	audus	audus	PROPN
admet-2043	824	10	,	,	PUNCT
admet-2043	824	11	r.t	r.t	PROPN
admet-2043	824	12	.	.	PROPN
admet-2043	824	13	borchardt	borchardt	ADJ
admet-2043	824	14	.	.	PUNCT
admet-2043	825	1	blood	blood	NOUN
admet-2043	825	2	-	-	PUNCT
admet-2043	825	3	brain	brain	NOUN
admet-2043	825	4	barrier	barrier	NOUN
admet-2043	825	5	:	:	PUNCT
admet-2043	825	6	transport	transport	NOUN
admet-2043	825	7	studies	study	NOUN
admet-2043	825	8	in	in	ADP
admet-2043	825	9	isolated	isolated	ADJ
admet-2043	825	10	brain	brain	NOUN
admet-2043	825	11	capillaries	capillary	NOUN
admet-2043	825	12	and	and	CCONJ
admet-2043	825	13	in	in	ADP
admet-2043	825	14	cultured	cultured	ADJ
admet-2043	825	15	brain	brain	NOUN
admet-2043	825	16	endothelial	endothelial	ADJ
admet-2043	825	17	cells	cell	NOUN
admet-2043	825	18	.	.	PUNCT
admet-2043	826	1	advances	advance	NOUN
admet-2043	826	2	in	in	ADP
admet-2043	826	3	pharmacology	pharmacology	NOUN
admet-2043	826	4	22	22	NUM
admet-2043	826	5	(	(	PUNCT
admet-2043	826	6	1991	1991	NUM
admet-2043	826	7	)	)	PUNCT
admet-2043	826	8	137	137	NUM
admet-2043	826	9	-	-	SYM
admet-2043	826	10	165	165	NUM
admet-2043	826	11	.	.	PUNCT
admet-2043	827	1	https://doi.org/10.1016/s1054-3589(08)60034-4	https://doi.org/10.1016/s1054-3589(08)60034-4	NOUN
admet-2043	827	2	.	.	PUNCT
admet-2043	828	1	[	[	X
admet-2043	828	2	16	16	NUM
admet-2043	828	3	]	]	X
admet-2043	828	4	j.j	j.j	PROPN
admet-2043	828	5	.	.	PROPN
admet-2043	828	6	rodriguez	rodriguez	PROPN
admet-2043	828	7	-	-	PUNCT
admet-2043	828	8	arellano	arellano	PROPN
admet-2043	828	9	,	,	PUNCT
admet-2043	828	10	v.	v.	ADP
admet-2043	828	11	parpura	parpura	NOUN
admet-2043	828	12	,	,	PUNCT
admet-2043	828	13	r.	r.	PROPN
admet-2043	828	14	zorec	zorec	PROPN
admet-2043	828	15	,	,	PUNCT
admet-2043	828	16	a.	a.	NOUN
admet-2043	828	17	verkhratsky	verkhratsky	NOUN
admet-2043	828	18	.	.	PUNCT
admet-2043	829	1	astrocytes	astrocyte	NOUN
admet-2043	829	2	in	in	ADP
admet-2043	829	3	physiological	physiological	ADJ
admet-2043	829	4	aging	aging	NOUN
admet-2043	829	5	and	and	CCONJ
admet-2043	829	6	alzheimer	alzheimer	NOUN
admet-2043	829	7	's	's	PART
admet-2043	829	8	disease	disease	NOUN
admet-2043	829	9	.	.	PUNCT
admet-2043	830	1	neuroscience	neuroscience	NOUN
admet-2043	830	2	323	323	NUM
admet-2043	830	3	(	(	PUNCT
admet-2043	830	4	2016	2016	NUM
admet-2043	830	5	)	)	PUNCT
admet-2043	830	6	170	170	NUM
admet-2043	830	7	-	-	SYM
admet-2043	830	8	182	182	NUM
admet-2043	830	9	.	.	PUNCT
admet-2043	831	1	https://doi.org/10.1016/j.neuroscience.2015.01.007	https://doi.org/10.1016/j.neuroscience.2015.01.007	VERB
admet-2043	831	2	.	.	PUNCT
admet-2043	832	1	[	[	X
admet-2043	832	2	17	17	NUM
admet-2043	832	3	]	]	X
admet-2043	832	4	n.j	n.j	PROPN
admet-2043	832	5	.	.	PROPN
admet-2043	832	6	abbott	abbott	PROPN
admet-2043	832	7	,	,	PUNCT
admet-2043	832	8	l.	l.	PROPN
admet-2043	832	9	ronnback	ronnback	PROPN
admet-2043	832	10	,	,	PUNCT
admet-2043	832	11	e.	e.	PROPN
admet-2043	832	12	hansson	hansson	PROPN
admet-2043	832	13	.	.	PUNCT
admet-2043	833	1	astrocyte	astrocyte	ADJ
admet-2043	833	2	-	-	PUNCT
admet-2043	833	3	endothelial	endothelial	ADJ
admet-2043	833	4	interactions	interaction	NOUN
admet-2043	833	5	at	at	ADP
admet-2043	833	6	the	the	DET
admet-2043	833	7	blood	blood	NOUN
admet-2043	833	8	-	-	PUNCT
admet-2043	833	9	brain	brain	NOUN
admet-2043	833	10	barrier	barrier	NOUN
admet-2043	833	11	.	.	PUNCT
admet-2043	834	1	nature	nature	NOUN
admet-2043	834	2	reviews	review	VERB
admet-2043	834	3	neuroscience	neuroscience	NOUN
admet-2043	834	4	7	7	NUM
admet-2043	834	5	(	(	PUNCT
admet-2043	834	6	2006	2006	NUM
admet-2043	834	7	)	)	PUNCT
admet-2043	834	8	41	41	NUM
admet-2043	834	9	-	-	SYM
admet-2043	834	10	53	53	NUM
admet-2043	834	11	.	.	PUNCT
admet-2043	834	12	https://doi.org/10.1038/nrn1824	https://doi.org/10.1038/nrn1824	NOUN
admet-2043	834	13	.	.	PUNCT
admet-2043	835	1	[	[	X
admet-2043	835	2	18	18	NUM
admet-2043	835	3	]	]	X
admet-2043	835	4	m.v	m.v	PROPN
admet-2043	835	5	.	.	PROPN
admet-2043	835	6	sofroniew	sofroniew	PROPN
admet-2043	835	7	,	,	PUNCT
admet-2043	835	8	h.v	h.v	PROPN
admet-2043	835	9	.	.	PROPN
admet-2043	835	10	vinters	vinter	NOUN
admet-2043	835	11	.	.	PUNCT
admet-2043	836	1	astrocytes	astrocyte	NOUN
admet-2043	836	2	:	:	PUNCT
admet-2043	836	3	biology	biology	NOUN
admet-2043	836	4	and	and	CCONJ
admet-2043	836	5	pathology	pathology	NOUN
admet-2043	836	6	.	.	PUNCT
admet-2043	837	1	acta	acta	PROPN
admet-2043	837	2	neuropathologica	neuropathologica	PROPN
admet-2043	837	3	119	119	NUM
admet-2043	837	4	(	(	PUNCT
admet-2043	837	5	2010	2010	NUM
admet-2043	837	6	)	)	PUNCT
admet-2043	837	7	7	7	NUM
admet-2043	837	8	-	-	SYM
admet-2043	837	9	35	35	NUM
admet-2043	837	10	.	.	PUNCT
admet-2043	837	11	https://doi.org/10.1007/s00401-009-0619-8	https://doi.org/10.1007/s00401-009-0619-8	X
admet-2043	837	12	.	.	PUNCT
admet-2043	838	1	[	[	X
admet-2043	838	2	19	19	NUM
admet-2043	838	3	]	]	X
admet-2043	838	4	d.	d.	PROPN
admet-2043	838	5	shepro	shepro	PROPN
admet-2043	838	6	,	,	PUNCT
admet-2043	838	7	n.m	n.m	PROPN
admet-2043	838	8	.	.	PROPN
admet-2043	838	9	morel	morel	PROPN
admet-2043	838	10	.	.	PUNCT
admet-2043	839	1	pericyte	pericyte	NOUN
admet-2043	839	2	physiology	physiology	NOUN
admet-2043	839	3	.	.	PUNCT
admet-2043	840	1	faseb	faseb	PROPN
admet-2043	840	2	journal	journal	PROPN
admet-2043	840	3	7	7	NUM
admet-2043	840	4	(	(	PUNCT
admet-2043	840	5	1993	1993	NUM
admet-2043	840	6	)	)	PUNCT
admet-2043	840	7	1031	1031	NUM
admet-2043	840	8	-	-	SYM
admet-2043	840	9	1038	1038	NUM
admet-2043	840	10	.	.	PUNCT
admet-2043	841	1	https://doi.org/10.1096/fasebj.7.11.8370472	https://doi.org/10.1096/fasebj.7.11.8370472	X
admet-2043	841	2	.	.	PUNCT
admet-2043	842	1	[	[	X
admet-2043	842	2	20	20	NUM
admet-2043	842	3	]	]	X
admet-2043	842	4	c.h	c.h	PROPN
admet-2043	842	5	.	.	PROPN
admet-2043	842	6	lai	lai	PROPN
admet-2043	842	7	,	,	PUNCT
admet-2043	842	8	k.h	k.h	PROPN
admet-2043	842	9	.	.	PROPN
admet-2043	842	10	kuo	kuo	PROPN
admet-2043	842	11	.	.	PUNCT
admet-2043	843	1	the	the	DET
admet-2043	843	2	critical	critical	ADJ
admet-2043	843	3	component	component	NOUN
admet-2043	843	4	to	to	PART
admet-2043	843	5	establish	establish	VERB
admet-2043	843	6	in	in	ADP
admet-2043	843	7	vitro	vitro	X
admet-2043	843	8	bbb	bbb	PROPN
admet-2043	843	9	model	model	NOUN
admet-2043	843	10	:	:	PUNCT
admet-2043	843	11	pericyte	pericyte	NOUN
admet-2043	843	12	.	.	PUNCT
admet-2043	844	1	brain	brain	NOUN
admet-2043	844	2	research	research	NOUN
admet-2043	844	3	reviews	review	VERB
admet-2043	844	4	50	50	NUM
admet-2043	844	5	(	(	PUNCT
admet-2043	844	6	2005	2005	NUM
admet-2043	844	7	)	)	PUNCT
admet-2043	844	8	258	258	NUM
admet-2043	844	9	-	-	SYM
admet-2043	844	10	265	265	NUM
admet-2043	844	11	.	.	PUNCT
admet-2043	845	1	https://doi.org/10.1016/j.brainresrev.2005.07.004	https://doi.org/10.1016/j.brainresrev.2005.07.004	NOUN
admet-2043	845	2	.	.	PUNCT
admet-2043	846	1	[	[	X
admet-2043	846	2	21	21	NUM
admet-2043	846	3	]	]	X
admet-2043	846	4	w.e	w.e	PROPN
admet-2043	846	5	.	.	PROPN
admet-2043	846	6	thomas	thomas	PROPN
admet-2043	846	7	.	.	PUNCT
admet-2043	847	1	brain	brain	NOUN
admet-2043	847	2	macrophages	macrophage	NOUN
admet-2043	847	3	:	:	PUNCT
admet-2043	847	4	on	on	ADP
admet-2043	847	5	the	the	DET
admet-2043	847	6	role	role	NOUN
admet-2043	847	7	of	of	ADP
admet-2043	847	8	pericytes	pericyte	NOUN
admet-2043	847	9	and	and	CCONJ
admet-2043	847	10	perivascular	perivascular	ADJ
admet-2043	847	11	cells	cell	NOUN
admet-2043	847	12	.	.	PUNCT
admet-2043	848	1	brain	brain	NOUN
admet-2043	848	2	research	research	NOUN
admet-2043	848	3	reviews	review	NOUN
admet-2043	848	4	31	31	NUM
admet-2043	848	5	(	(	PUNCT
admet-2043	848	6	1999	1999	NUM
admet-2043	848	7	)	)	PUNCT
admet-2043	848	8	42	42	NUM
admet-2043	848	9	-	-	SYM
admet-2043	848	10	57	57	NUM
admet-2043	848	11	.	.	PUNCT
admet-2043	849	1	https://doi.org/10.1016/s0165-0173(99)00024-7	https://doi.org/10.1016/s0165-0173(99)00024-7	PROPN
admet-2043	849	2	.	.	PUNCT
admet-2043	850	1	[	[	X
admet-2043	850	2	22	22	NUM
admet-2043	850	3	]	]	X
admet-2043	850	4	s.	s.	PROPN
admet-2043	850	5	liebner	liebner	PROPN
admet-2043	850	6	,	,	PUNCT
admet-2043	850	7	c.j	c.j	PROPN
admet-2043	850	8	.	.	PROPN
admet-2043	850	9	czupalla	czupalla	PROPN
admet-2043	850	10	,	,	PUNCT
admet-2043	850	11	h.	h.	PROPN
admet-2043	850	12	wolburg	wolburg	PROPN
admet-2043	850	13	.	.	PUNCT
admet-2043	851	1	current	current	ADJ
admet-2043	851	2	concepts	concept	NOUN
admet-2043	851	3	of	of	ADP
admet-2043	851	4	blood	blood	NOUN
admet-2043	851	5	-	-	PUNCT
admet-2043	851	6	brain	brain	NOUN
admet-2043	851	7	barrier	barrier	NOUN
admet-2043	851	8	development	development	NOUN
admet-2043	851	9	.	.	PUNCT
admet-2043	852	1	international	international	ADJ
admet-2043	852	2	journal	journal	PROPN
admet-2043	852	3	of	of	ADP
admet-2043	852	4	developmental	developmental	ADJ
admet-2043	852	5	biology	biology	NOUN
admet-2043	852	6	55	55	NUM
admet-2043	852	7	(	(	PUNCT
admet-2043	852	8	2011	2011	NUM
admet-2043	852	9	)	)	PUNCT
admet-2043	852	10	467	467	NUM
admet-2043	852	11	-	-	SYM
admet-2043	852	12	476	476	NUM
admet-2043	852	13	.	.	PUNCT
admet-2043	853	1	https://doi.org/10.1387/ijdb.103224sl	https://doi.org/10.1387/ijdb.103224sl	INTJ
admet-2043	853	2	.	.	PUNCT
admet-2043	854	1	[	[	X
admet-2043	854	2	23	23	NUM
admet-2043	854	3	]	]	X
admet-2043	854	4	a.j	a.j	PROPN
admet-2043	854	5	.	.	PROPN
admet-2043	854	6	hansen	hansen	PROPN
admet-2043	854	7	.	.	PROPN
admet-2043	854	8	effect	effect	NOUN
admet-2043	854	9	of	of	ADP
admet-2043	854	10	anoxia	anoxia	NOUN
admet-2043	854	11	on	on	ADP
admet-2043	854	12	ion	ion	NOUN
admet-2043	854	13	distribution	distribution	NOUN
admet-2043	854	14	in	in	ADP
admet-2043	854	15	the	the	DET
admet-2043	854	16	brain	brain	NOUN
admet-2043	854	17	.	.	PUNCT
admet-2043	855	1	physiological	physiological	ADJ
admet-2043	855	2	reviews	review	NOUN
admet-2043	855	3	65	65	NUM
admet-2043	855	4	(	(	PUNCT
admet-2043	855	5	1985	1985	NUM
admet-2043	855	6	)	)	PUNCT
admet-2043	855	7	101148	101148	NUM
admet-2043	855	8	.	.	PUNCT
admet-2043	856	1	https://doi.org/10.1152/physrev.1985.65.1.101	https://doi.org/10.1152/physrev.1985.65.1.101	NOUN
admet-2043	856	2	.	.	PUNCT
admet-2043	857	1	[	[	X
admet-2043	857	2	24	24	NUM
admet-2043	857	3	]	]	SYM
admet-2043	857	4	s.b	s.b	PROPN
admet-2043	857	5	.	.	NOUN
admet-2043	857	6	hladky	hladky	PROPN
admet-2043	857	7	,	,	PUNCT
admet-2043	857	8	m.a	m.a	PROPN
admet-2043	857	9	.	.	PROPN
admet-2043	857	10	barrand	barrand	NOUN
admet-2043	857	11	.	.	PUNCT
admet-2043	858	1	elimination	elimination	NOUN
admet-2043	858	2	of	of	ADP
admet-2043	858	3	substances	substance	NOUN
admet-2043	858	4	from	from	ADP
admet-2043	858	5	the	the	DET
admet-2043	858	6	brain	brain	NOUN
admet-2043	858	7	parenchyma	parenchyma	NOUN
admet-2043	858	8	:	:	PUNCT
admet-2043	858	9	efflux	efflux	VERB
admet-2043	858	10	via	via	ADP
admet-2043	858	11	perivascular	perivascular	ADJ
admet-2043	858	12	pathways	pathway	NOUN
admet-2043	858	13	and	and	CCONJ
admet-2043	858	14	via	via	ADP
admet-2043	858	15	the	the	DET
admet-2043	858	16	blood	blood	NOUN
admet-2043	858	17	-	-	PUNCT
admet-2043	858	18	brain	brain	NOUN
admet-2043	858	19	barrier	barrier	NOUN
admet-2043	858	20	.	.	PUNCT
admet-2043	859	1	fluids	fluid	NOUN
admet-2043	859	2	and	and	CCONJ
admet-2043	859	3	barriers	barrier	NOUN
admet-2043	859	4	of	of	ADP
admet-2043	859	5	the	the	DET
admet-2043	859	6	cns	cns	PROPN
admet-2043	859	7	15	15	NUM
admet-2043	859	8	(	(	PUNCT
admet-2043	859	9	2018	2018	NUM
admet-2043	859	10	)	)	PUNCT
admet-2043	859	11	30	30	NUM
admet-2043	859	12	.	.	PUNCT
admet-2043	860	1	https://doi.org/10.1186/s12987-018-0113-6	https://doi.org/10.1186/s12987-018-0113-6	X
admet-2043	860	2	.	.	PUNCT
admet-2043	861	1	[	[	X
admet-2043	861	2	25	25	NUM
admet-2043	861	3	]	]	X
admet-2043	861	4	n.j	n.j	PROPN
admet-2043	861	5	.	.	PROPN
admet-2043	861	6	abbott	abbott	PROPN
admet-2043	861	7	,	,	PUNCT
admet-2043	861	8	a.a	a.a	PROPN
admet-2043	861	9	.	.	PROPN
admet-2043	861	10	patabendige	patabendige	PROPN
admet-2043	861	11	,	,	PUNCT
admet-2043	861	12	d.e	d.e	PROPN
admet-2043	861	13	.	.	PROPN
admet-2043	861	14	dolman	dolman	PROPN
admet-2043	861	15	,	,	PUNCT
admet-2043	861	16	s.r	s.r	PROPN
admet-2043	861	17	.	.	PROPN
admet-2043	861	18	yusof	yusof	PROPN
admet-2043	861	19	,	,	PUNCT
admet-2043	861	20	d.j	d.j	PROPN
admet-2043	861	21	.	.	PROPN
admet-2043	861	22	begley	begley	PROPN
admet-2043	861	23	.	.	PUNCT
admet-2043	862	1	structure	structure	NOUN
admet-2043	862	2	and	and	CCONJ
admet-2043	862	3	function	function	NOUN
admet-2043	862	4	of	of	ADP
admet-2043	862	5	the	the	DET
admet-2043	862	6	blood	blood	NOUN
admet-2043	862	7	-	-	PUNCT
admet-2043	862	8	brain	brain	NOUN
admet-2043	862	9	barrier	barrier	NOUN
admet-2043	862	10	.	.	PUNCT
admet-2043	863	1	neurobiology	neurobiology	NOUN
admet-2043	863	2	of	of	ADP
admet-2043	863	3	disease	disease	NOUN
admet-2043	863	4	37	37	NUM
admet-2043	863	5	(	(	PUNCT
admet-2043	863	6	2010	2010	NUM
admet-2043	863	7	)	)	PUNCT
admet-2043	863	8	13	13	NUM
admet-2043	863	9	-	-	SYM
admet-2043	863	10	25	25	NUM
admet-2043	863	11	.	.	PUNCT
admet-2043	864	1	https://doi.org/10.1016/j.nbd.2009.07.030	https://doi.org/10.1016/j.nbd.2009.07.030	PROPN
admet-2043	864	2	.	.	PUNCT
admet-2043	865	1	[	[	X
admet-2043	865	2	26	26	NUM
admet-2043	865	3	]	]	X
admet-2043	865	4	d.a	d.a	PROPN
admet-2043	865	5	.	.	PROPN
admet-2043	865	6	lim	lim	PROPN
admet-2043	865	7	,	,	PUNCT
admet-2043	865	8	y.c	y.c	PROPN
admet-2043	865	9	.	.	PROPN
admet-2043	865	10	huang	huang	PROPN
admet-2043	865	11	,	,	PUNCT
admet-2043	865	12	a.	a.	PROPN
admet-2043	865	13	alvarez	alvarez	PROPN
admet-2043	865	14	-	-	PUNCT
admet-2043	865	15	buylla	buylla	NOUN
admet-2043	865	16	.	.	PUNCT
admet-2043	866	1	the	the	DET
admet-2043	866	2	adult	adult	NOUN
admet-2043	866	3	neural	neural	ADJ
admet-2043	866	4	stem	stem	NOUN
admet-2043	866	5	cell	cell	NOUN
admet-2043	866	6	niche	niche	NOUN
admet-2043	866	7	:	:	PUNCT
admet-2043	866	8	lessons	lesson	NOUN
admet-2043	866	9	for	for	ADP
admet-2043	866	10	future	future	ADJ
admet-2043	866	11	neural	neural	ADJ
admet-2043	866	12	cell	cell	NOUN
admet-2043	866	13	replacement	replacement	NOUN
admet-2043	866	14	strategies	strategy	NOUN
admet-2043	866	15	.	.	PUNCT
admet-2043	867	1	neurosurgery	neurosurgery	ADJ
admet-2043	867	2	clinics	clinic	NOUN
admet-2043	867	3	of	of	ADP
admet-2043	867	4	north	north	PROPN
admet-2043	867	5	america	america	PROPN
admet-2043	867	6	18	18	NUM
admet-2043	867	7	(	(	PUNCT
admet-2043	867	8	2007	2007	NUM
admet-2043	867	9	)	)	PUNCT
admet-2043	867	10	81	81	NUM
admet-2043	867	11	-	-	SYM
admet-2043	867	12	92	92	NUM
admet-2043	867	13	,	,	PUNCT
admet-2043	867	14	ix	ix	ADJ
admet-2043	867	15	.	.	PUNCT
admet-2043	868	1	https://doi.org/10.1016/j.nec.2006.10.002	https://doi.org/10.1016/j.nec.2006.10.002	ADV
admet-2043	868	2	.	.	PUNCT
admet-2043	869	1	[	[	X
admet-2043	869	2	27	27	NUM
admet-2043	869	3	]	]	X
admet-2043	869	4	m.l	m.l	PROPN
admet-2043	869	5	.	.	PUNCT
admet-2043	869	6	hans	hans	PROPN
admet-2043	869	7	,	,	PUNCT
admet-2043	869	8	a.m.	a.m.	PROPN
admet-2043	869	9	lowman	lowman	PROPN
admet-2043	869	10	.	.	PUNCT
admet-2043	870	1	biodegradable	biodegradable	ADJ
admet-2043	870	2	nanoparticles	nanoparticle	NOUN
admet-2043	870	3	for	for	ADP
admet-2043	870	4	drug	drug	NOUN
admet-2043	870	5	delivery	delivery	NOUN
admet-2043	870	6	and	and	CCONJ
admet-2043	870	7	targeting	targeting	NOUN
admet-2043	870	8	.	.	PUNCT
admet-2043	871	1	current	current	ADJ
admet-2043	871	2	opinion	opinion	NOUN
admet-2043	871	3	in	in	ADP
admet-2043	871	4	solid	solid	ADJ
admet-2043	871	5	state	state	NOUN
admet-2043	871	6	and	and	CCONJ
admet-2043	871	7	materials	material	NOUN
admet-2043	871	8	science	science	NOUN
admet-2043	871	9	6	6	NUM
admet-2043	871	10	(	(	PUNCT
admet-2043	871	11	2002	2002	NUM
admet-2043	871	12	)	)	PUNCT
admet-2043	871	13	319	319	NUM
admet-2043	871	14	-	-	SYM
admet-2043	871	15	327	327	NUM
admet-2043	871	16	.	.	PUNCT
admet-2043	871	17	https://doi.org/10.1016/s13590286(02)00117-1	https://doi.org/10.1016/s13590286(02)00117-1	NOUN
admet-2043	871	18	.	.	PUNCT
admet-2043	872	1	[	[	X
admet-2043	872	2	28	28	NUM
admet-2043	872	3	]	]	X
admet-2043	872	4	f.u	f.u	PROPN
admet-2043	872	5	.	.	PUNCT
admet-2043	872	6	din	din	PROPN
admet-2043	872	7	,	,	PUNCT
admet-2043	872	8	w.	w.	PROPN
admet-2043	872	9	aman	aman	PROPN
admet-2043	872	10	,	,	PUNCT
admet-2043	872	11	i.	i.	PROPN
admet-2043	872	12	ullah	ullah	PROPN
admet-2043	872	13	,	,	PUNCT
admet-2043	872	14	o.s	o.s	PROPN
admet-2043	872	15	.	.	PROPN
admet-2043	872	16	qureshi	qureshi	PROPN
admet-2043	872	17	,	,	PUNCT
admet-2043	872	18	o.	o.	PROPN
admet-2043	872	19	mustapha	mustapha	PROPN
admet-2043	872	20	,	,	PUNCT
admet-2043	872	21	s.	s.	PROPN
admet-2043	872	22	shafique	shafique	PROPN
admet-2043	872	23	,	,	PUNCT
admet-2043	872	24	a.	a.	PROPN
admet-2043	872	25	zeb	zeb	PROPN
admet-2043	872	26	.	.	PUNCT
admet-2043	872	27	effective	effective	ADJ
admet-2043	872	28	use	use	NOUN
admet-2043	872	29	of	of	ADP
admet-2043	872	30	nanocarriers	nanocarrier	NOUN
admet-2043	872	31	as	as	ADP
admet-2043	872	32	drug	drug	NOUN
admet-2043	872	33	delivery	delivery	NOUN
admet-2043	872	34	systems	system	NOUN
admet-2043	872	35	for	for	ADP
admet-2043	872	36	the	the	DET
admet-2043	872	37	treatment	treatment	NOUN
admet-2043	872	38	of	of	ADP
admet-2043	872	39	selected	select	VERB
admet-2043	872	40	tumors	tumor	NOUN
admet-2043	872	41	.	.	PUNCT
admet-2043	873	1	international	international	ADJ
admet-2043	873	2	journal	journal	PROPN
admet-2043	873	3	of	of	ADP
admet-2043	873	4	nanomedicine	nanomedicine	NOUN
admet-2043	873	5	12	12	NUM
admet-2043	873	6	(	(	PUNCT
admet-2043	873	7	2017	2017	NUM
admet-2043	873	8	)	)	PUNCT
admet-2043	873	9	7291	7291	NUM
admet-2043	873	10	-	-	SYM
admet-2043	873	11	7309	7309	NUM
admet-2043	873	12	.	.	PUNCT
admet-2043	874	1	https://doi.org/10.2147/ijn.s146315	https://doi.org/10.2147/ijn.s146315	NUM
admet-2043	874	2	.	.	PUNCT
admet-2043	875	1	[	[	X
admet-2043	875	2	29	29	NUM
admet-2043	875	3	]	]	X
admet-2043	875	4	n.	n.	PROPN
admet-2043	875	5	faisal	faisal	PROPN
admet-2043	875	6	,	,	PUNCT
admet-2043	875	7	k.	k.	PROPN
admet-2043	875	8	kumar	kumar	PROPN
admet-2043	875	9	.	.	PUNCT
admet-2043	875	10	polymer	polymer	NOUN
admet-2043	875	11	and	and	CCONJ
admet-2043	875	12	metal	metal	NOUN
admet-2043	875	13	nanocomposites	nanocomposite	NOUN
admet-2043	875	14	in	in	ADP
admet-2043	875	15	biomedical	biomedical	ADJ
admet-2043	875	16	applications	application	NOUN
admet-2043	875	17	.	.	PUNCT
admet-2043	876	1	biointerface	biointerface	NOUN
admet-2043	876	2	research	research	NOUN
admet-2043	876	3	in	in	ADP
admet-2043	876	4	applied	apply	VERB
admet-2043	876	5	chemistry	chemistry	NOUN
admet-2043	876	6	7	7	NUM
admet-2043	876	7	(	(	PUNCT
admet-2043	876	8	2017	2017	NUM
admet-2043	876	9	)	)	PUNCT
admet-2043	876	10	2286	2286	NUM
admet-2043	876	11	-	-	SYM
admet-2043	876	12	2294	2294	NUM
admet-2043	876	13	.	.	PUNCT
admet-2043	876	14	https://doi.org/https://doi.org/10.2017/revised	https://doi.org/https://doi.org/10.2017/revise	VERB
admet-2043	876	15	.	.	PUNCT
admet-2043	877	1	[	[	X
admet-2043	877	2	30	30	NUM
admet-2043	877	3	]	]	X
admet-2043	877	4	c.h	c.h	PROPN
admet-2043	877	5	.	.	PROPN
admet-2043	877	6	choi	choi	PROPN
admet-2043	877	7	,	,	PUNCT
admet-2043	877	8	c.a	c.a	PROPN
admet-2043	877	9	.	.	PROPN
admet-2043	877	10	alabi	alabi	PROPN
admet-2043	877	11	,	,	PUNCT
admet-2043	877	12	p.	p.	PROPN
admet-2043	877	13	webster	webster	PROPN
admet-2043	877	14	,	,	PUNCT
admet-2043	877	15	m.e	m.e	PROPN
admet-2043	877	16	.	.	PROPN
admet-2043	877	17	davis	davis	PROPN
admet-2043	877	18	.	.	PUNCT
admet-2043	878	1	mechanism	mechanism	NOUN
admet-2043	878	2	of	of	ADP
admet-2043	878	3	active	active	ADJ
admet-2043	878	4	targeting	targeting	NOUN
admet-2043	878	5	in	in	ADP
admet-2043	878	6	solid	solid	ADJ
admet-2043	878	7	tumors	tumor	NOUN
admet-2043	878	8	with	with	ADP
admet-2043	878	9	transferrin	transferrin	NOUN
admet-2043	878	10	-	-	PUNCT
admet-2043	878	11	containing	contain	VERB
admet-2043	878	12	gold	gold	NOUN
admet-2043	878	13	nanoparticles	nanoparticle	NOUN
admet-2043	878	14	.	.	PUNCT
admet-2043	879	1	proceedings	proceeding	NOUN
admet-2043	879	2	of	of	ADP
admet-2043	879	3	the	the	DET
admet-2043	879	4	national	national	PROPN
admet-2043	879	5	academy	academy	PROPN
admet-2043	879	6	of	of	ADP
admet-2043	879	7	sciences	sciences	PROPN
admet-2043	879	8	of	of	ADP
admet-2043	879	9	the	the	DET
admet-2043	879	10	united	united	PROPN
admet-2043	879	11	states	states	PROPN
admet-2043	879	12	of	of	ADP
admet-2043	879	13	america	america	PROPN
admet-2043	879	14	107	107	NUM
admet-2043	879	15	(	(	PUNCT
admet-2043	879	16	2010	2010	NUM
admet-2043	879	17	)	)	PUNCT
admet-2043	879	18	1235	1235	NUM
admet-2043	879	19	-	-	SYM
admet-2043	879	20	1240	1240	NUM
admet-2043	879	21	.	.	PUNCT
admet-2043	880	1	https://doi.org/10.1073/pnas.0914140107	https://doi.org/10.1073/pnas.0914140107	NOUN
admet-2043	880	2	.	.	PUNCT
admet-2043	881	1	[	[	X
admet-2043	881	2	31	31	NUM
admet-2043	881	3	]	]	X
admet-2043	881	4	d.t	d.t	PROPN
admet-2043	881	5	.	.	PROPN
admet-2043	881	6	wiley	wiley	PROPN
admet-2043	881	7	,	,	PUNCT
admet-2043	881	8	p.	p.	PROPN
admet-2043	881	9	webster	webster	PROPN
admet-2043	881	10	,	,	PUNCT
admet-2043	881	11	a.	a.	PROPN
admet-2043	881	12	gale	gale	PROPN
admet-2043	881	13	,	,	PUNCT
admet-2043	881	14	m.e	m.e	PROPN
admet-2043	881	15	.	.	PROPN
admet-2043	881	16	davis	davis	PROPN
admet-2043	881	17	.	.	PUNCT
admet-2043	882	1	transcytosis	transcytosis	NOUN
admet-2043	882	2	and	and	CCONJ
admet-2043	882	3	brain	brain	NOUN
admet-2043	882	4	uptake	uptake	NOUN
admet-2043	882	5	of	of	ADP
admet-2043	882	6	transferrin	transferrin	NOUN
admet-2043	882	7	-	-	PUNCT
admet-2043	882	8	containing	contain	VERB
admet-2043	882	9	nanoparticles	nanoparticle	NOUN
admet-2043	882	10	by	by	ADP
admet-2043	882	11	tuning	tune	VERB
admet-2043	882	12	avidity	avidity	NOUN
admet-2043	882	13	to	to	ADP
admet-2043	882	14	transferrin	transferrin	NOUN
admet-2043	882	15	receptor	receptor	NOUN
admet-2043	882	16	.	.	PUNCT
admet-2043	883	1	proceedings	proceeding	NOUN
admet-2043	883	2	of	of	ADP
admet-2043	883	3	the	the	DET
admet-2043	883	4	national	national	PROPN
admet-2043	883	5	academy	academy	PROPN
admet-2043	883	6	of	of	ADP
admet-2043	883	7	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	PROPN
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admet-2043	883	9	https://doi.org/10.1124/pr.57.2.4	https://doi.org/10.1124/pr.57.2.4	VERB
admet-2043	883	10	https://doi.org/10.1016/s1054-3589(08)60034-4	https://doi.org/10.1016/s1054-3589(08)60034-4	PRON
admet-2043	883	11	https://doi.org/10.1016/j.neuroscience.2015.01.007	https://doi.org/10.1016/j.neuroscience.2015.01.007	ADJ
admet-2043	883	12	https://doi.org/10.1038/nrn1824	https://doi.org/10.1038/nrn1824	NOUN
admet-2043	883	13	https://doi.org/10.1007/s00401-009-0619-8	https://doi.org/10.1007/s00401-009-0619-8	PART
admet-2043	884	1	https://doi.org/10.1096/fasebj.7.11.8370472	https://doi.org/10.1096/fasebj.7.11.8370472	NOUN
admet-2043	884	2	https://doi.org/10.1016/j.brainresrev.2005.07.004	https://doi.org/10.1016/j.brainresrev.2005.07.004	PROPN
admet-2043	884	3	https://doi.org/10.1016/s0165-0173(99)00024-7	https://doi.org/10.1016/s0165-0173(99)00024-7	X
admet-2043	884	4	https://doi.org/10.1387/ijdb.103224sl	https://doi.org/10.1387/ijdb.103224sl	NOUN
admet-2043	885	1	https://doi.org/10.1152/physrev.1985.65.1.101	https://doi.org/10.1152/physrev.1985.65.1.101	PROPN
admet-2043	885	2	https://doi.org/10.1186/s12987-018-0113-6	https://doi.org/10.1186/s12987-018-0113-6	NUM
admet-2043	885	3	https://doi.org/10.1016/j.nbd.2009.07.030	https://doi.org/10.1016/j.nbd.2009.07.030	PROPN
admet-2043	885	4	https://doi.org/10.1016/j.nec.2006.10.002	https://doi.org/10.1016/j.nec.2006.10.002	PROPN
admet-2043	885	5	https://doi.org/10.1016/s1359-0286(02)00117-1	https://doi.org/10.1016/s1359-0286(02)00117-1	PROPN
admet-2043	885	6	https://doi.org/10.1016/s1359-0286(02)00117-1	https://doi.org/10.1016/s1359-0286(02)00117-1	PROPN
admet-2043	885	7	https://doi.org/10.2147/ijn.s146315	https://doi.org/10.2147/ijn.s146315	PROPN
admet-2043	885	8	https://doi.org/https:/doi.org/10.2017/revised	https://doi.org/https:/doi.org/10.2017/revise	VERB
admet-2043	885	9	https://doi.org/10.1073/pnas.0914140107	https://doi.org/10.1073/pnas.0914140107	NOUN
admet-2043	885	10	m.	m.	PROPN
admet-2043	885	11	kulkarni	kulkarni	PROPN
admet-2043	885	12	et	et	PROPN
admet-2043	885	13	al	al	PROPN
admet-2043	885	14	.	.	PROPN
admet-2043	885	15	admet	admet	PROPN
admet-2043	885	16	&	&	CCONJ
admet-2043	885	17	dmpk	dmpk	PROPN
admet-2043	885	18	12(1	12(1	PROPN
admet-2043	885	19	)	)	PUNCT
admet-2043	885	20	(	(	PUNCT
admet-2043	885	21	2024	2024	NUM
admet-2043	885	22	)	)	PUNCT
admet-2043	885	23	63	63	NUM
admet-2043	885	24	-	-	SYM
admet-2043	885	25	105	105	NUM
admet-2043	885	26	94	94	NUM
admet-2043	885	27	sciences	science	NOUN
admet-2043	885	28	of	of	ADP
admet-2043	885	29	the	the	DET
admet-2043	885	30	united	united	PROPN
admet-2043	885	31	states	states	PROPN
admet-2043	885	32	of	of	ADP
admet-2043	885	33	america	america	PROPN
admet-2043	885	34	110	110	NUM
admet-2043	885	35	(	(	PUNCT
admet-2043	885	36	2013	2013	NUM
admet-2043	885	37	)	)	PUNCT
admet-2043	885	38	8662	8662	NUM
admet-2043	885	39	-	-	SYM
admet-2043	885	40	8667	8667	NUM
admet-2043	885	41	.	.	PUNCT
admet-2043	886	1	https://doi.org/10.1073/pnas.1307152110	https://doi.org/10.1073/pnas.1307152110	NOUN
admet-2043	886	2	.	.	PUNCT
admet-2043	887	1	[	[	X
admet-2043	887	2	32	32	NUM
admet-2043	887	3	]	]	X
admet-2043	887	4	s.d	s.d	PROPN
admet-2043	887	5	.	.	PROPN
admet-2043	887	6	kong	kong	PROPN
admet-2043	887	7	,	,	PUNCT
admet-2043	887	8	j.	j.	PROPN
admet-2043	887	9	lee	lee	PROPN
admet-2043	887	10	,	,	PUNCT
admet-2043	887	11	s.	s.	PROPN
admet-2043	887	12	ramachandran	ramachandran	PROPN
admet-2043	887	13	,	,	PUNCT
admet-2043	887	14	b.p	b.p	PROPN
admet-2043	887	15	.	.	PROPN
admet-2043	887	16	eliceiri	eliceiri	PROPN
admet-2043	887	17	,	,	PUNCT
admet-2043	887	18	v.i	v.i	PROPN
admet-2043	887	19	.	.	PROPN
admet-2043	887	20	shubayev	shubayev	PROPN
admet-2043	887	21	,	,	PUNCT
admet-2043	887	22	r.	r.	PROPN
admet-2043	887	23	lal	lal	PROPN
admet-2043	887	24	,	,	PUNCT
admet-2043	887	25	s.	s.	PROPN
admet-2043	887	26	jin	jin	PROPN
admet-2043	887	27	.	.	PUNCT
admet-2043	888	1	magnetic	magnetic	ADJ
admet-2043	888	2	targeting	targeting	NOUN
admet-2043	888	3	of	of	ADP
admet-2043	888	4	nanoparticles	nanoparticle	NOUN
admet-2043	888	5	across	across	ADP
admet-2043	888	6	the	the	DET
admet-2043	888	7	intact	intact	ADJ
admet-2043	888	8	blood	blood	NOUN
admet-2043	888	9	-	-	PUNCT
admet-2043	888	10	brain	brain	NOUN
admet-2043	888	11	barrier	barrier	NOUN
admet-2043	888	12	.	.	PUNCT
admet-2043	889	1	journal	journal	NOUN
admet-2043	889	2	of	of	ADP
admet-2043	889	3	controlled	control	VERB
admet-2043	889	4	release	release	NOUN
admet-2043	889	5	164	164	NUM
admet-2043	889	6	(	(	PUNCT
admet-2043	889	7	2012	2012	NUM
admet-2043	889	8	)	)	PUNCT
admet-2043	889	9	4957	4957	NUM
admet-2043	889	10	.	.	PUNCT
admet-2043	890	1	https://doi.org/10.1016/j.jconrel.2012.09.021	https://doi.org/10.1016/j.jconrel.2012.09.021	NOUN
admet-2043	890	2	.	.	PUNCT
admet-2043	891	1	[	[	X
admet-2043	891	2	33	33	NUM
admet-2043	891	3	]	]	X
admet-2043	891	4	b.s	b.s	PROPN
admet-2043	891	5	.	.	PROPN
admet-2043	891	6	karmur	karmur	PROPN
admet-2043	891	7	,	,	PUNCT
admet-2043	891	8	j.	j.	PROPN
admet-2043	891	9	philteos	philteos	PROPN
admet-2043	891	10	,	,	PUNCT
admet-2043	891	11	a.	a.	PROPN
admet-2043	891	12	abbasian	abbasian	PROPN
admet-2043	891	13	,	,	PUNCT
admet-2043	891	14	b.e	b.e	PROPN
admet-2043	891	15	.	.	PROPN
admet-2043	891	16	zacharia	zacharia	PROPN
admet-2043	891	17	,	,	PUNCT
admet-2043	891	18	n.	n.	NOUN
admet-2043	891	19	lipsman	lipsman	NOUN
admet-2043	891	20	,	,	PUNCT
admet-2043	891	21	v.	v.	PROPN
admet-2043	891	22	levin	levin	PROPN
admet-2043	891	23	,	,	PUNCT
admet-2043	891	24	s.	s.	PROPN
admet-2043	891	25	grossman	grossman	PROPN
admet-2043	891	26	,	,	PUNCT
admet-2043	891	27	a.	a.	PROPN
admet-2043	891	28	mansouri	mansouri	PROPN
admet-2043	891	29	.	.	PUNCT
admet-2043	892	1	blood	blood	NOUN
admet-2043	892	2	-	-	PUNCT
admet-2043	892	3	brain	brain	NOUN
admet-2043	892	4	barrier	barrier	NOUN
admet-2043	892	5	disruption	disruption	NOUN
admet-2043	892	6	in	in	ADP
admet-2043	892	7	neuro	neuro	NOUN
admet-2043	892	8	-	-	PUNCT
admet-2043	892	9	oncology	oncology	NOUN
admet-2043	892	10	:	:	PUNCT
admet-2043	892	11	strategies	strategy	NOUN
admet-2043	892	12	,	,	PUNCT
admet-2043	892	13	failures	failure	NOUN
admet-2043	892	14	,	,	PUNCT
admet-2043	892	15	and	and	CCONJ
admet-2043	892	16	challenges	challenge	NOUN
admet-2043	892	17	to	to	PART
admet-2043	892	18	overcome	overcome	VERB
admet-2043	892	19	.	.	PUNCT
admet-2043	893	1	frontiers	frontier	NOUN
admet-2043	893	2	in	in	ADP
admet-2043	893	3	oncology	oncology	NOUN
admet-2043	893	4	10	10	NUM
admet-2043	893	5	(	(	PUNCT
admet-2043	893	6	2020	2020	NUM
admet-2043	893	7	)	)	PUNCT
admet-2043	893	8	563840	563840	NUM
admet-2043	893	9	.	.	PUNCT
admet-2043	894	1	https://doi.org/10.3389/fonc.2020.563840	https://doi.org/10.3389/fonc.2020.563840	PROPN
admet-2043	894	2	.	.	PUNCT
admet-2043	895	1	[	[	X
admet-2043	895	2	34	34	NUM
admet-2043	895	3	]	]	X
admet-2043	895	4	c.t	c.t	PROPN
admet-2043	895	5	.	.	PROPN
admet-2043	895	6	lu	lu	PROPN
admet-2043	895	7	,	,	PUNCT
admet-2043	895	8	y.z	y.z	PROPN
admet-2043	895	9	.	.	PROPN
admet-2043	895	10	zhao	zhao	PROPN
admet-2043	895	11	,	,	PUNCT
admet-2043	895	12	h.l	h.l	PROPN
admet-2043	895	13	.	.	PROPN
admet-2043	895	14	wong	wong	PROPN
admet-2043	895	15	,	,	PUNCT
admet-2043	895	16	j.	j.	PROPN
admet-2043	895	17	cai	cai	PROPN
admet-2043	895	18	,	,	PUNCT
admet-2043	895	19	l.	l.	PROPN
admet-2043	895	20	peng	peng	PROPN
admet-2043	895	21	,	,	PUNCT
admet-2043	895	22	x.q	x.q	PROPN
admet-2043	895	23	.	.	PROPN
admet-2043	895	24	tian	tian	PROPN
admet-2043	895	25	.	.	PUNCT
admet-2043	896	1	current	current	ADJ
admet-2043	896	2	approaches	approach	NOUN
admet-2043	896	3	to	to	PART
admet-2043	896	4	enhance	enhance	VERB
admet-2043	896	5	cns	cns	NOUN
admet-2043	896	6	delivery	delivery	NOUN
admet-2043	896	7	of	of	ADP
admet-2043	896	8	drugs	drug	NOUN
admet-2043	896	9	across	across	ADP
admet-2043	896	10	the	the	DET
admet-2043	896	11	brain	brain	NOUN
admet-2043	896	12	barriers	barrier	NOUN
admet-2043	896	13	.	.	PUNCT
admet-2043	897	1	international	international	ADJ
admet-2043	897	2	journal	journal	NOUN
admet-2043	897	3	of	of	ADP
admet-2043	897	4	nanomedicine	nanomedicine	NOUN
admet-2043	897	5	9	9	NUM
admet-2043	897	6	(	(	PUNCT
admet-2043	897	7	2014	2014	NUM
admet-2043	897	8	)	)	PUNCT
admet-2043	897	9	22412257	22412257	NUM
admet-2043	897	10	.	.	PUNCT
admet-2043	898	1	https://doi.org/10.2147/ijn.s61288	https://doi.org/10.2147/ijn.s61288	ADJ
admet-2043	898	2	.	.	PUNCT
admet-2043	899	1	[	[	X
admet-2043	899	2	35	35	NUM
admet-2043	899	3	]	]	X
admet-2043	899	4	s.	s.	PROPN
admet-2043	899	5	soni	soni	PROPN
admet-2043	899	6	,	,	PUNCT
admet-2043	899	7	r.k	r.k	PROPN
admet-2043	899	8	.	.	PROPN
admet-2043	899	9	ruhela	ruhela	PROPN
admet-2043	899	10	,	,	PUNCT
admet-2043	899	11	b.	b.	PROPN
admet-2043	899	12	medhi	medhi	PROPN
admet-2043	899	13	.	.	PUNCT
admet-2043	900	1	nanomedicine	nanomedicine	PROPN
admet-2043	900	2	in	in	ADP
admet-2043	900	3	central	central	ADJ
admet-2043	900	4	nervous	nervous	ADJ
admet-2043	900	5	system	system	NOUN
admet-2043	900	6	(	(	PUNCT
admet-2043	900	7	cns	cns	NOUN
admet-2043	900	8	)	)	PUNCT
admet-2043	900	9	disorders	disorder	NOUN
admet-2043	900	10	:	:	PUNCT
admet-2043	900	11	a	a	DET
admet-2043	900	12	present	present	ADJ
admet-2043	900	13	and	and	CCONJ
admet-2043	900	14	future	future	ADJ
admet-2043	900	15	prospective	prospective	ADJ
admet-2043	900	16	.	.	PUNCT
admet-2043	901	1	advanced	advanced	ADJ
admet-2043	901	2	pharmaceutical	pharmaceutical	ADJ
admet-2043	901	3	bulletin	bulletin	NOUN
admet-2043	901	4	6	6	NUM
admet-2043	901	5	(	(	PUNCT
admet-2043	901	6	2016	2016	NUM
admet-2043	901	7	)	)	PUNCT
admet-2043	901	8	319	319	NUM
admet-2043	901	9	-	-	SYM
admet-2043	901	10	335	335	NUM
admet-2043	901	11	.	.	PUNCT
admet-2043	902	1	https://doi.org/10.15171/apb.2016.044	https://doi.org/10.15171/apb.2016.044	PROPN
admet-2043	902	2	.	.	PUNCT
admet-2043	903	1	[	[	X
admet-2043	903	2	36	36	NUM
admet-2043	903	3	]	]	X
admet-2043	903	4	s.g	s.g	PROPN
admet-2043	903	5	.	.	PROPN
admet-2043	903	6	patel	patel	PROPN
admet-2043	903	7	,	,	PUNCT
admet-2043	903	8	m.d	m.d	PROPN
admet-2043	903	9	.	.	PROPN
admet-2043	903	10	patel	patel	PROPN
admet-2043	903	11	,	,	PUNCT
admet-2043	903	12	a.j	a.j	PROPN
admet-2043	903	13	.	.	PROPN
admet-2043	903	14	patel	patel	PROPN
admet-2043	903	15	,	,	PUNCT
admet-2043	903	16	m.b	m.b	PROPN
admet-2043	903	17	.	.	PROPN
admet-2043	903	18	chougule	chougule	PROPN
admet-2043	903	19	,	,	PUNCT
admet-2043	903	20	h.	h.	PROPN
admet-2043	903	21	choudhury	choudhury	PROPN
admet-2043	903	22	,	,	PUNCT
admet-2043	903	23	solid	solid	ADJ
admet-2043	903	24	lipid	lipid	ADJ
admet-2043	903	25	nanoparticles	nanoparticle	NOUN
admet-2043	903	26	for	for	ADP
admet-2043	903	27	targeted	target	VERB
admet-2043	903	28	brain	brain	NOUN
admet-2043	903	29	drug	drug	NOUN
admet-2043	903	30	delivery	delivery	NOUN
admet-2043	903	31	,	,	PUNCT
admet-2043	903	32	in	in	ADP
admet-2043	903	33	nanotechnology	nanotechnology	NOUN
admet-2043	903	34	-	-	PUNCT
admet-2043	903	35	based	base	VERB
admet-2043	903	36	targeted	target	VERB
admet-2043	903	37	drug	drug	NOUN
admet-2043	903	38	delivery	delivery	NOUN
admet-2043	903	39	systems	system	NOUN
admet-2043	903	40	for	for	ADP
admet-2043	903	41	brain	brain	NOUN
admet-2043	903	42	tumors	tumor	NOUN
admet-2043	903	43	,	,	PUNCT
admet-2043	903	44	elsevier2018	elsevier2018	NOUN
admet-2043	903	45	,	,	PUNCT
admet-2043	903	46	p.	p.	NOUN
admet-2043	903	47	191	191	NUM
admet-2043	903	48	-	-	SYM
admet-2043	903	49	244	244	NUM
admet-2043	903	50	9780128122181	9780128122181	NUM
admet-2043	903	51	.	.	PUNCT
admet-2043	904	1	https://doi.org/10.1016/b978-0-12-8122181.00008-7	https://doi.org/10.1016/b978-0-12-8122181.00008-7	X
admet-2043	904	2	.	.	PUNCT
admet-2043	905	1	[	[	X
admet-2043	905	2	37	37	NUM
admet-2043	905	3	]	]	X
admet-2043	905	4	f.	f.	PROPN
admet-2043	905	5	juhairiyah	juhairiyah	PROPN
admet-2043	905	6	,	,	PUNCT
admet-2043	905	7	e.c.m	e.c.m	ADJ
admet-2043	905	8	.	.	PUNCT
admet-2043	905	9	de	de	X
admet-2043	905	10	lange	lange	NOUN
admet-2043	905	11	.	.	PUNCT
admet-2043	906	1	understanding	understand	VERB
admet-2043	906	2	drug	drug	NOUN
admet-2043	906	3	delivery	delivery	NOUN
admet-2043	906	4	to	to	ADP
admet-2043	906	5	the	the	DET
admet-2043	906	6	brain	brain	NOUN
admet-2043	906	7	using	use	VERB
admet-2043	906	8	liposome	liposome	NOUN
admet-2043	906	9	-	-	PUNCT
admet-2043	906	10	based	base	VERB
admet-2043	906	11	strategies	strategy	NOUN
admet-2043	906	12	:	:	PUNCT
admet-2043	906	13	studies	study	NOUN
admet-2043	906	14	that	that	PRON
admet-2043	906	15	provide	provide	VERB
admet-2043	906	16	mechanistic	mechanistic	ADJ
admet-2043	906	17	insights	insight	NOUN
admet-2043	906	18	are	be	AUX
admet-2043	906	19	essential	essential	ADJ
admet-2043	906	20	.	.	PUNCT
admet-2043	907	1	aaps	aap	NOUN
admet-2043	907	2	journal	journal	PROPN
admet-2043	907	3	23	23	NUM
admet-2043	907	4	(	(	PUNCT
admet-2043	907	5	2021	2021	NUM
admet-2043	907	6	)	)	PUNCT
admet-2043	907	7	114	114	NUM
admet-2043	907	8	.	.	PUNCT
admet-2043	908	1	https://doi.org/10.1208/s12248-021-00648-z	https://doi.org/10.1208/s12248-021-00648-z	PROPN
admet-2043	908	2	.	.	PUNCT
admet-2043	909	1	[	[	X
admet-2043	909	2	38	38	NUM
admet-2043	909	3	]	]	PUNCT
admet-2043	909	4	a.	a.	NOUN
admet-2043	909	5	anand	anand	PROPN
admet-2043	909	6	,	,	PUNCT
admet-2043	909	7	a.	a.	NOUN
admet-2043	909	8	sugumaran	sugumaran	NOUN
admet-2043	909	9	,	,	PUNCT
admet-2043	909	10	d.	d.	PROPN
admet-2043	909	11	narayanasamy	narayanasamy	PROPN
admet-2043	909	12	.	.	PUNCT
admet-2043	910	1	brain	brain	NOUN
admet-2043	910	2	targeted	target	VERB
admet-2043	910	3	delivery	delivery	NOUN
admet-2043	910	4	of	of	ADP
admet-2043	910	5	anticancer	anticancer	NOUN
admet-2043	910	6	drugs	drug	NOUN
admet-2043	910	7	:	:	PUNCT
admet-2043	910	8	prospective	prospective	ADJ
admet-2043	910	9	approach	approach	NOUN
admet-2043	910	10	using	use	VERB
admet-2043	910	11	solid	solid	ADJ
admet-2043	910	12	lipid	lipid	ADJ
admet-2043	910	13	nanoparticles	nanoparticle	NOUN
admet-2043	910	14	.	.	PUNCT
admet-2043	911	1	iet	iet	PROPN
admet-2043	911	2	nanobiotechnol	nanobiotechnol	PROPN
admet-2043	911	3	13	13	NUM
admet-2043	911	4	(	(	PUNCT
admet-2043	911	5	2019	2019	NUM
admet-2043	911	6	)	)	PUNCT
admet-2043	911	7	353	353	NUM
admet-2043	911	8	-	-	NUM
admet-2043	911	9	362	362	NUM
admet-2043	911	10	.	.	PUNCT
admet-2043	912	1	https://doi.org/10.1049/iet-nbt.2018.5322	https://doi.org/10.1049/iet-nbt.2018.5322	PROPN
admet-2043	912	2	.	.	PUNCT
admet-2043	913	1	[	[	X
admet-2043	913	2	39	39	NUM
admet-2043	913	3	]	]	X
admet-2043	913	4	e.e	e.e	PROPN
admet-2043	913	5	.	.	PROPN
admet-2043	913	6	n	n	PROPN
admet-2043	913	7	,	,	PUNCT
admet-2043	913	8	m.o	m.o	PROPN
admet-2043	913	9	.	.	PROPN
admet-2043	913	10	m	m	PROPN
admet-2043	913	11	,	,	PUNCT
admet-2043	913	12	a.m.	a.m.	PROPN
admet-2043	913	13	h	h	PROPN
admet-2043	913	14	,	,	PUNCT
admet-2043	913	15	a.a.-t	a.a.-t	PROPN
admet-2043	913	16	.	.	PUNCT
admet-2043	914	1	h.	h.	PROPN
admet-2043	914	2	nanostructured	nanostructure	VERB
admet-2043	914	3	lipid	lipid	NOUN
admet-2043	914	4	carriers	carrier	NOUN
admet-2043	914	5	to	to	PART
admet-2043	914	6	mediate	mediate	VERB
admet-2043	914	7	brain	brain	NOUN
admet-2043	914	8	delivery	delivery	NOUN
admet-2043	914	9	of	of	ADP
admet-2043	914	10	temazepam	temazepam	NOUN
admet-2043	914	11	:	:	PUNCT
admet-2043	914	12	design	design	NOUN
admet-2043	914	13	and	and	CCONJ
admet-2043	914	14	in	in	ADP
admet-2043	914	15	vivo	vivo	NOUN
admet-2043	914	16	study	study	NOUN
admet-2043	914	17	.	.	PUNCT
admet-2043	915	1	pharmaceutics	pharmaceutic	NOUN
admet-2043	915	2	12	12	NUM
admet-2043	915	3	(	(	PUNCT
admet-2043	915	4	2020	2020	NUM
admet-2043	915	5	)	)	PUNCT
admet-2043	915	6	.	.	PUNCT
admet-2043	916	1	https://doi.org/10.3390/pharmaceutics12050451	https://doi.org/10.3390/pharmaceutics12050451	PROPN
admet-2043	916	2	.	.	PUNCT
admet-2043	917	1	[	[	X
admet-2043	917	2	40	40	NUM
admet-2043	917	3	]	]	PUNCT
admet-2043	917	4	d.	d.	PROPN
admet-2043	917	5	ag	ag	PROPN
admet-2043	917	6	seleci	seleci	PROPN
admet-2043	917	7	,	,	PUNCT
admet-2043	917	8	m.	m.	PROPN
admet-2043	917	9	seleci	seleci	PROPN
admet-2043	917	10	,	,	PUNCT
admet-2043	918	1	j.-g	j.-g	PROPN
admet-2043	918	2	.	.	PUNCT
admet-2043	918	3	walter	walter	PROPN
admet-2043	918	4	,	,	PUNCT
admet-2043	918	5	f.	f.	PROPN
admet-2043	918	6	stahl	stahl	PROPN
admet-2043	918	7	,	,	PUNCT
admet-2043	918	8	t.	t.	PROPN
admet-2043	918	9	scheper	scheper	PROPN
admet-2043	918	10	.	.	PUNCT
admet-2043	919	1	niosomes	niosome	NOUN
admet-2043	919	2	as	as	ADP
admet-2043	919	3	nanoparticular	nanoparticular	ADJ
admet-2043	919	4	drug	drug	NOUN
admet-2043	919	5	carriers	carrier	NOUN
admet-2043	919	6	:	:	PUNCT
admet-2043	919	7	fundamentals	fundamental	NOUN
admet-2043	919	8	and	and	CCONJ
admet-2043	919	9	recent	recent	ADJ
admet-2043	919	10	applications	application	NOUN
admet-2043	919	11	.	.	PUNCT
admet-2043	920	1	journal	journal	NOUN
admet-2043	920	2	of	of	ADP
admet-2043	920	3	nanomaterials	nanomaterial	NOUN
admet-2043	920	4	2016	2016	NUM
admet-2043	920	5	(	(	PUNCT
admet-2043	920	6	2016	2016	NUM
admet-2043	920	7	)	)	PUNCT
admet-2043	920	8	1	1	NUM
admet-2043	920	9	-	-	SYM
admet-2043	920	10	13	13	NUM
admet-2043	920	11	.	.	PUNCT
admet-2043	921	1	https://doi.org/10.1155/2016/7372306	https://doi.org/10.1155/2016/7372306	PROPN
admet-2043	921	2	.	.	PUNCT
admet-2043	922	1	[	[	X
admet-2043	922	2	41	41	NUM
admet-2043	922	3	]	]	X
admet-2043	922	4	b.s	b.s	PROPN
admet-2043	922	5	.	.	PROPN
admet-2043	922	6	pattni	pattni	PROPN
admet-2043	922	7	,	,	PUNCT
admet-2043	922	8	v.v	v.v	PROPN
admet-2043	922	9	.	.	PROPN
admet-2043	922	10	chupin	chupin	PROPN
admet-2043	922	11	,	,	PUNCT
admet-2043	922	12	v.p	v.p	PROPN
admet-2043	922	13	.	.	PROPN
admet-2043	922	14	torchilin	torchilin	PROPN
admet-2043	922	15	.	.	PUNCT
admet-2043	923	1	new	new	ADJ
admet-2043	923	2	developments	development	NOUN
admet-2043	923	3	in	in	ADP
admet-2043	923	4	liposomal	liposomal	ADJ
admet-2043	923	5	drug	drug	NOUN
admet-2043	923	6	delivery	delivery	NOUN
admet-2043	923	7	.	.	PUNCT
admet-2043	924	1	chemical	chemical	ADJ
admet-2043	924	2	reviews	review	NOUN
admet-2043	924	3	115	115	NUM
admet-2043	924	4	(	(	PUNCT
admet-2043	924	5	2015	2015	NUM
admet-2043	924	6	)	)	PUNCT
admet-2043	924	7	10938	10938	NUM
admet-2043	924	8	-	-	SYM
admet-2043	924	9	10966	10966	NUM
admet-2043	924	10	.	.	PUNCT
admet-2043	925	1	https://doi.org/10.1021/acs.chemrev.5b00046	https://doi.org/10.1021/acs.chemrev.5b00046	ADJ
admet-2043	925	2	.	.	PUNCT
admet-2043	926	1	[	[	X
admet-2043	926	2	42	42	NUM
admet-2043	926	3	]	]	X
admet-2043	926	4	r.r	r.r	PROPN
admet-2043	926	5	.	.	PROPN
admet-2043	926	6	sawant	sawant	PROPN
admet-2043	926	7	,	,	PUNCT
admet-2043	926	8	v.p	v.p	PROPN
admet-2043	926	9	.	.	PROPN
admet-2043	926	10	torchilin	torchilin	PROPN
admet-2043	926	11	.	.	PUNCT
admet-2043	927	1	challenges	challenge	NOUN
admet-2043	927	2	in	in	ADP
admet-2043	927	3	development	development	NOUN
admet-2043	927	4	of	of	ADP
admet-2043	927	5	targeted	target	VERB
admet-2043	927	6	liposomal	liposomal	ADJ
admet-2043	927	7	therapeutics	therapeutic	NOUN
admet-2043	927	8	.	.	PUNCT
admet-2043	928	1	aaps	aap	NOUN
admet-2043	928	2	journal	journal	PROPN
admet-2043	928	3	14	14	NUM
admet-2043	928	4	(	(	PUNCT
admet-2043	928	5	2012	2012	NUM
admet-2043	928	6	)	)	PUNCT
admet-2043	928	7	303	303	NUM
admet-2043	928	8	-	-	SYM
admet-2043	928	9	315	315	NUM
admet-2043	928	10	.	.	PUNCT
admet-2043	929	1	https://doi.org/10.1208/s12248-012-9330-0	https://doi.org/10.1208/s12248-012-9330-0	NUM
admet-2043	929	2	.	.	PUNCT
admet-2043	930	1	[	[	X
admet-2043	930	2	43	43	NUM
admet-2043	930	3	]	]	X
admet-2043	930	4	j.	j.	PROPN
admet-2043	930	5	ezzati	ezzati	PROPN
admet-2043	930	6	nazhad	nazhad	VERB
admet-2043	930	7	dolatabadi	dolatabadi	PROPN
admet-2043	930	8	,	,	PUNCT
admet-2043	930	9	y.	y.	PROPN
admet-2043	930	10	omidi	omidi	PROPN
admet-2043	930	11	.	.	PUNCT
admet-2043	931	1	solid	solid	ADJ
admet-2043	931	2	lipid	lipid	NOUN
admet-2043	931	3	-	-	PUNCT
admet-2043	931	4	based	base	VERB
admet-2043	931	5	nanocarriers	nanocarrier	NOUN
admet-2043	931	6	as	as	ADP
admet-2043	931	7	efficient	efficient	ADJ
admet-2043	931	8	targeted	target	VERB
admet-2043	931	9	drug	drug	NOUN
admet-2043	931	10	and	and	CCONJ
admet-2043	931	11	gene	gene	NOUN
admet-2043	931	12	delivery	delivery	NOUN
admet-2043	931	13	systems	system	NOUN
admet-2043	931	14	.	.	PUNCT
admet-2043	932	1	trac	trac	NOUN
admet-2043	932	2	trends	trend	NOUN
admet-2043	932	3	in	in	ADP
admet-2043	932	4	analytical	analytical	ADJ
admet-2043	932	5	chemistry	chemistry	NOUN
admet-2043	932	6	77	77	NUM
admet-2043	932	7	(	(	PUNCT
admet-2043	932	8	2016	2016	NUM
admet-2043	932	9	)	)	PUNCT
admet-2043	932	10	100	100	NUM
admet-2043	932	11	-	-	SYM
admet-2043	932	12	108	108	NUM
admet-2043	932	13	.	.	PUNCT
admet-2043	933	1	https://doi.org/10.1016/j.trac.2015.12.016	https://doi.org/10.1016/j.trac.2015.12.016	PROPN
admet-2043	933	2	.	.	PUNCT
admet-2043	934	1	[	[	X
admet-2043	934	2	44	44	NUM
admet-2043	934	3	]	]	PUNCT
admet-2043	934	4	a.	a.	NOUN
admet-2043	934	5	beloqui	beloqui	PROPN
admet-2043	934	6	,	,	PUNCT
admet-2043	934	7	m.a	m.a	PROPN
admet-2043	934	8	.	.	PROPN
admet-2043	934	9	solinis	solinis	PROPN
admet-2043	934	10	,	,	PUNCT
admet-2043	934	11	a.	a.	PROPN
admet-2043	934	12	rodriguez	rodriguez	PROPN
admet-2043	934	13	-	-	PUNCT
admet-2043	934	14	gascon	gascon	PROPN
admet-2043	934	15	,	,	PUNCT
admet-2043	934	16	a.j	a.j	PROPN
admet-2043	934	17	.	.	PROPN
admet-2043	934	18	almeida	almeida	PROPN
admet-2043	934	19	,	,	PUNCT
admet-2043	934	20	v.	v.	ADP
admet-2043	934	21	preat	preat	PROPN
admet-2043	934	22	.	.	PUNCT
admet-2043	935	1	nanostructured	nanostructure	VERB
admet-2043	935	2	lipid	lipid	NOUN
admet-2043	935	3	carriers	carrier	NOUN
admet-2043	935	4	:	:	PUNCT
admet-2043	935	5	promising	promise	VERB
admet-2043	935	6	drug	drug	NOUN
admet-2043	935	7	delivery	delivery	NOUN
admet-2043	935	8	systems	system	NOUN
admet-2043	935	9	for	for	ADP
admet-2043	935	10	future	future	ADJ
admet-2043	935	11	clinics	clinic	NOUN
admet-2043	935	12	.	.	PUNCT
admet-2043	936	1	nanomedicine	nanomedicine	NOUN
admet-2043	936	2	:	:	PUNCT
admet-2043	936	3	nanotechnology	nanotechnology	NOUN
admet-2043	936	4	,	,	PUNCT
admet-2043	936	5	biology	biology	NOUN
admet-2043	936	6	,	,	PUNCT
admet-2043	936	7	and	and	CCONJ
admet-2043	936	8	medicine	medicine	NOUN
admet-2043	936	9	12	12	NUM
admet-2043	936	10	(	(	PUNCT
admet-2043	936	11	2016	2016	NUM
admet-2043	936	12	)	)	PUNCT
admet-2043	936	13	143	143	NUM
admet-2043	936	14	-	-	SYM
admet-2043	936	15	161	161	NUM
admet-2043	936	16	.	.	PUNCT
admet-2043	937	1	https://doi.org/10.1016/j.nano.2015.09.004	https://doi.org/10.1016/j.nano.2015.09.004	PROPN
admet-2043	937	2	.	.	PUNCT
admet-2043	938	1	[	[	X
admet-2043	938	2	45	45	NUM
admet-2043	938	3	]	]	X
admet-2043	938	4	a.r	a.r	PROPN
admet-2043	938	5	.	.	PROPN
admet-2043	938	6	jones	jones	PROPN
admet-2043	938	7	,	,	PUNCT
admet-2043	938	8	e.v	e.v	PROPN
admet-2043	938	9	.	.	PROPN
admet-2043	938	10	shusta	shusta	NOUN
admet-2043	938	11	.	.	PUNCT
admet-2043	939	1	blood	blood	NOUN
admet-2043	939	2	-	-	PUNCT
admet-2043	939	3	brain	brain	NOUN
admet-2043	939	4	barrier	barrier	NOUN
admet-2043	939	5	transport	transport	NOUN
admet-2043	939	6	of	of	ADP
admet-2043	939	7	therapeutics	therapeutic	NOUN
admet-2043	939	8	via	via	ADP
admet-2043	939	9	receptor	receptor	NOUN
admet-2043	939	10	-	-	PUNCT
admet-2043	939	11	mediation	mediation	NOUN
admet-2043	939	12	.	.	PUNCT
admet-2043	940	1	pharmaceutical	pharmaceutical	PROPN
admet-2043	940	2	research	research	NOUN
admet-2043	940	3	24	24	NUM
admet-2043	940	4	(	(	PUNCT
admet-2043	940	5	2007	2007	NUM
admet-2043	940	6	)	)	PUNCT
admet-2043	940	7	1759	1759	NUM
admet-2043	940	8	-	-	SYM
admet-2043	940	9	1771	1771	NUM
admet-2043	940	10	.	.	PUNCT
admet-2043	941	1	https://doi.org/10.1007/s11095-007-9379-0	https://doi.org/10.1007/s11095-007-9379-0	VERB
admet-2043	941	2	.	.	PUNCT
admet-2043	942	1	[	[	X
admet-2043	942	2	46	46	NUM
admet-2043	942	3	]	]	X
admet-2043	942	4	r.	r.	PROPN
admet-2043	942	5	qiao	qiao	PROPN
admet-2043	942	6	,	,	PUNCT
admet-2043	942	7	q.	q.	PROPN
admet-2043	942	8	jia	jia	PROPN
admet-2043	942	9	,	,	PUNCT
admet-2043	942	10	s.	s.	PROPN
admet-2043	942	11	huwel	huwel	PROPN
admet-2043	942	12	,	,	PUNCT
admet-2043	942	13	r.	r.	PROPN
admet-2043	942	14	xia	xia	PROPN
admet-2043	942	15	,	,	PUNCT
admet-2043	942	16	t.	t.	PROPN
admet-2043	942	17	liu	liu	PROPN
admet-2043	942	18	,	,	PUNCT
admet-2043	942	19	f.	f.	PROPN
admet-2043	942	20	gao	gao	PROPN
admet-2043	942	21	,	,	PUNCT
admet-2043	942	22	h.j	h.j	PROPN
admet-2043	942	23	.	.	PROPN
admet-2043	942	24	galla	galla	PROPN
admet-2043	942	25	,	,	PUNCT
admet-2043	942	26	m.	m.	NOUN
admet-2043	942	27	gao	gao	PROPN
admet-2043	942	28	.	.	PUNCT
admet-2043	943	1	receptor	receptor	NOUN
admet-2043	943	2	-	-	PUNCT
admet-2043	943	3	mediated	mediate	VERB
admet-2043	943	4	delivery	delivery	NOUN
admet-2043	943	5	of	of	ADP
admet-2043	943	6	magnetic	magnetic	ADJ
admet-2043	943	7	nanoparticles	nanoparticle	NOUN
admet-2043	943	8	across	across	ADP
admet-2043	943	9	the	the	DET
admet-2043	943	10	blood	blood	NOUN
admet-2043	943	11	-	-	PUNCT
admet-2043	943	12	brain	brain	NOUN
admet-2043	943	13	barrier	barrier	NOUN
admet-2043	943	14	.	.	PUNCT
admet-2043	944	1	acs	acs	PROPN
admet-2043	944	2	nano	nano	VERB
admet-2043	944	3	6	6	NUM
admet-2043	944	4	(	(	PUNCT
admet-2043	944	5	2012	2012	NUM
admet-2043	944	6	)	)	PUNCT
admet-2043	944	7	3304	3304	NUM
admet-2043	944	8	-	-	SYM
admet-2043	944	9	3310	3310	NUM
admet-2043	944	10	.	.	PUNCT
admet-2043	945	1	https://doi.org/10.1021/nn300240p	https://doi.org/10.1021/nn300240p	NOUN
admet-2043	945	2	.	.	PUNCT
admet-2043	946	1	[	[	X
admet-2043	946	2	47	47	NUM
admet-2043	946	3	]	]	PUNCT
admet-2043	946	4	a.m.	a.m.	PROPN
admet-2043	947	1	hersh	hersh	PROPN
admet-2043	947	2	,	,	PUNCT
admet-2043	947	3	s.	s.	PROPN
admet-2043	947	4	alomari	alomari	PROPN
admet-2043	947	5	,	,	PUNCT
admet-2043	947	6	b.m	b.m	PROPN
admet-2043	947	7	.	.	PROPN
admet-2043	947	8	tyler	tyler	PROPN
admet-2043	947	9	.	.	PUNCT
admet-2043	948	1	crossing	cross	VERB
admet-2043	948	2	the	the	DET
admet-2043	948	3	blood	blood	NOUN
admet-2043	948	4	-	-	PUNCT
admet-2043	948	5	brain	brain	NOUN
admet-2043	948	6	barrier	barrier	NOUN
admet-2043	948	7	:	:	PUNCT
admet-2043	948	8	advances	advance	NOUN
admet-2043	948	9	in	in	ADP
admet-2043	948	10	nanoparticle	nanoparticle	NOUN
admet-2043	948	11	technology	technology	NOUN
admet-2043	948	12	for	for	ADP
admet-2043	948	13	drug	drug	NOUN
admet-2043	948	14	delivery	delivery	NOUN
admet-2043	948	15	in	in	ADP
admet-2043	948	16	neuro	neuro	NOUN
admet-2043	948	17	-	-	PUNCT
admet-2043	948	18	oncology	oncology	NOUN
admet-2043	948	19	.	.	PUNCT
admet-2043	949	1	international	international	ADJ
admet-2043	949	2	journal	journal	NOUN
admet-2043	949	3	of	of	ADP
admet-2043	949	4	molecular	molecular	ADJ
admet-2043	949	5	sciences	science	NOUN
admet-2043	949	6	23	23	NUM
admet-2043	949	7	(	(	PUNCT
admet-2043	949	8	2022	2022	NUM
admet-2043	949	9	)	)	PUNCT
admet-2043	949	10	4153	4153	NUM
admet-2043	949	11	-	-	SYM
admet-2043	949	12	4153	4153	NUM
admet-2043	949	13	.	.	PUNCT
admet-2043	950	1	https://doi.org/10.3390/ijms23084153	https://doi.org/10.3390/ijms23084153	PROPN
admet-2043	950	2	.	.	PUNCT
admet-2043	951	1	https://doi.org/10.1073/pnas.1307152110	https://doi.org/10.1073/pnas.1307152110	PROPN
admet-2043	951	2	https://doi.org/10.1016/j.jconrel.2012.09.021	https://doi.org/10.1016/j.jconrel.2012.09.021	PROPN
admet-2043	952	1	https://doi.org/10.3389/fonc.2020.563840	https://doi.org/10.3389/fonc.2020.563840	PROPN
admet-2043	952	2	https://doi.org/10.2147/ijn.s61288	https://doi.org/10.2147/ijn.s61288	NOUN
admet-2043	952	3	https://doi.org/10.15171/apb.2016.044	https://doi.org/10.15171/apb.2016.044	PROPN
admet-2043	952	4	https://doi.org/10.1016/b978-0-12-812218-1.00008-7	https://doi.org/10.1016/b978-0-12-812218-1.00008-7	PROPN
admet-2043	952	5	https://doi.org/10.1016/b978-0-12-812218-1.00008-7	https://doi.org/10.1016/b978-0-12-812218-1.00008-7	PROPN
admet-2043	952	6	https://doi.org/10.1208/s12248-021-00648-z	https://doi.org/10.1208/s12248-021-00648-z	PROPN
admet-2043	952	7	https://doi.org/10.1049/iet-nbt.2018.5322	https://doi.org/10.1049/iet-nbt.2018.5322	PROPN
admet-2043	953	1	https://doi.org/10.3390/pharmaceutics12050451	https://doi.org/10.3390/pharmaceutics12050451	PROPN
admet-2043	953	2	https://doi.org/10.1155/2016/7372306	https://doi.org/10.1155/2016/7372306	NOUN
admet-2043	954	1	https://doi.org/10.1021/acs.chemrev.5b00046	https://doi.org/10.1021/acs.chemrev.5b00046	INTJ
admet-2043	955	1	https://doi.org/10.1208/s12248-012-9330-0	https://doi.org/10.1208/s12248-012-9330-0	NUM
admet-2043	955	2	https://doi.org/10.1016/j.trac.2015.12.016	https://doi.org/10.1016/j.trac.2015.12.016	PROPN
admet-2043	955	3	https://doi.org/10.1016/j.nano.2015.09.004	https://doi.org/10.1016/j.nano.2015.09.004	PROPN
admet-2043	955	4	https://doi.org/10.1007/s11095-007-9379-0	https://doi.org/10.1007/s11095-007-9379-0	NUM
admet-2043	955	5	https://doi.org/10.1021/nn300240p	https://doi.org/10.1021/nn300240p	NOUN
admet-2043	955	6	https://doi.org/10.3390/ijms23084153	https://doi.org/10.3390/ijms23084153	VERB
admet-2043	955	7	admet	admet	PROPN
admet-2043	955	8	&	&	CCONJ
admet-2043	955	9	dmpk	dmpk	PROPN
admet-2043	955	10	12(1	12(1	PROPN
admet-2043	955	11	)	)	PUNCT
admet-2043	955	12	(	(	PUNCT
admet-2043	955	13	2024	2024	NUM
admet-2043	955	14	)	)	PUNCT
admet-2043	955	15	63	63	NUM
admet-2043	955	16	-	-	SYM
admet-2043	955	17	105	105	NUM
admet-2043	955	18	nanomaterials	nanomaterial	NOUN
admet-2043	955	19	as	as	ADP
admet-2043	955	20	drug	drug	NOUN
admet-2043	955	21	delivery	delivery	NOUN
admet-2043	955	22	agents	agent	NOUN
admet-2043	955	23	for	for	ADP
admet-2043	955	24	overcoming	overcome	VERB
admet-2043	955	25	bbb	bbb	PROPN
admet-2043	955	26	doi	doi	NOUN
admet-2043	955	27	:	:	PUNCT
admet-2043	955	28	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	955	29	95	95	NUM
admet-2043	956	1	[	[	X
admet-2043	956	2	48	48	NUM
admet-2043	956	3	]	]	PUNCT
admet-2043	956	4	m.	m.	PROPN
admet-2043	956	5	liang	liang	PROPN
admet-2043	956	6	,	,	PUNCT
admet-2043	956	7	c.	c.	PROPN
admet-2043	956	8	gao	gao	PROPN
admet-2043	956	9	,	,	PUNCT
admet-2043	956	10	y.	y.	PROPN
admet-2043	956	11	wang	wang	PROPN
admet-2043	956	12	,	,	PUNCT
admet-2043	956	13	w.	w.	PROPN
admet-2043	956	14	gong	gong	PROPN
admet-2043	956	15	,	,	PUNCT
admet-2043	956	16	s.	s.	PROPN
admet-2043	956	17	fu	fu	PROPN
admet-2043	956	18	,	,	PUNCT
admet-2043	956	19	l.	l.	PROPN
admet-2043	956	20	cui	cui	PROPN
admet-2043	956	21	,	,	PUNCT
admet-2043	956	22	z.	z.	PROPN
admet-2043	956	23	zhou	zhou	PROPN
admet-2043	956	24	,	,	PUNCT
admet-2043	956	25	x.	x.	PROPN
admet-2043	956	26	chu	chu	PROPN
admet-2043	956	27	,	,	PUNCT
admet-2043	956	28	y.	y.	PROPN
admet-2043	956	29	zhang	zhang	PROPN
admet-2043	956	30	,	,	PUNCT
admet-2043	956	31	q.	q.	PROPN
admet-2043	956	32	liu	liu	PROPN
admet-2043	956	33	,	,	PUNCT
admet-2043	956	34	x.	x.	PROPN
admet-2043	956	35	zhao	zhao	PROPN
admet-2043	956	36	,	,	PUNCT
admet-2043	956	37	b.	b.	PROPN
admet-2043	956	38	zhao	zhao	PROPN
admet-2043	956	39	,	,	PUNCT
admet-2043	956	40	m.	m.	PROPN
admet-2043	956	41	yang	yang	PROPN
admet-2043	956	42	,	,	PUNCT
admet-2043	956	43	z.	z.	PROPN
admet-2043	956	44	li	li	PROPN
admet-2043	956	45	,	,	PUNCT
admet-2043	956	46	c.	c.	PROPN
admet-2043	956	47	yang	yang	PROPN
admet-2043	956	48	,	,	PUNCT
admet-2043	956	49	x.	x.	PROPN
admet-2043	956	50	xie	xie	PROPN
admet-2043	956	51	,	,	PUNCT
admet-2043	956	52	y.	y.	PROPN
admet-2043	956	53	yang	yang	PROPN
admet-2043	956	54	,	,	PUNCT
admet-2043	956	55	c.	c.	PROPN
admet-2043	956	56	gao	gao	PROPN
admet-2043	956	57	.	.	PUNCT
admet-2043	957	1	enhanced	enhance	VERB
admet-2043	957	2	blood	blood	NOUN
admet-2043	957	3	-	-	PUNCT
admet-2043	957	4	brain	brain	NOUN
admet-2043	957	5	barrier	barrier	NOUN
admet-2043	957	6	penetration	penetration	NOUN
admet-2043	957	7	and	and	CCONJ
admet-2043	957	8	glioma	glioma	NOUN
admet-2043	957	9	therapy	therapy	NOUN
admet-2043	957	10	mediated	mediate	VERB
admet-2043	957	11	by	by	ADP
admet-2043	957	12	t7	t7	PROPN
admet-2043	957	13	peptide	peptide	NOUN
admet-2043	957	14	-	-	PUNCT
admet-2043	957	15	modified	modify	VERB
admet-2043	957	16	low	low	ADJ
admet-2043	957	17	-	-	PUNCT
admet-2043	957	18	density	density	NOUN
admet-2043	957	19	lipoprotein	lipoprotein	ADJ
admet-2043	957	20	particles	particle	NOUN
admet-2043	957	21	.	.	PUNCT
admet-2043	958	1	drug	drug	NOUN
admet-2043	958	2	delivery	delivery	NOUN
admet-2043	958	3	25	25	NUM
admet-2043	958	4	(	(	PUNCT
admet-2043	958	5	2018	2018	NUM
admet-2043	958	6	)	)	PUNCT
admet-2043	958	7	1652	1652	NUM
admet-2043	958	8	-	-	SYM
admet-2043	958	9	1663	1663	NUM
admet-2043	958	10	.	.	PUNCT
admet-2043	959	1	https://doi.org/10.1080/10717544.2018.1494223	https://doi.org/10.1080/10717544.2018.1494223	PROPN
admet-2043	959	2	.	.	PUNCT
admet-2043	960	1	[	[	X
admet-2043	960	2	49	49	NUM
admet-2043	960	3	]	]	PUNCT
admet-2043	960	4	h.	h.	PROPN
admet-2043	960	5	gao	gao	PROPN
admet-2043	960	6	.	.	PUNCT
admet-2043	961	1	progress	progress	NOUN
admet-2043	961	2	and	and	CCONJ
admet-2043	961	3	perspectives	perspective	NOUN
admet-2043	961	4	on	on	ADP
admet-2043	961	5	targeting	target	VERB
admet-2043	961	6	nanoparticles	nanoparticle	NOUN
admet-2043	961	7	for	for	ADP
admet-2043	961	8	brain	brain	NOUN
admet-2043	961	9	drug	drug	NOUN
admet-2043	961	10	delivery	delivery	NOUN
admet-2043	961	11	.	.	PUNCT
admet-2043	962	1	acta	acta	PROPN
admet-2043	962	2	pharmaceutica	pharmaceutica	PROPN
admet-2043	962	3	sinica	sinica	PROPN
admet-2043	962	4	b	b	PROPN
admet-2043	962	5	6	6	NUM
admet-2043	962	6	(	(	PUNCT
admet-2043	962	7	2016	2016	NUM
admet-2043	962	8	)	)	PUNCT
admet-2043	962	9	268	268	NUM
admet-2043	962	10	-	-	SYM
admet-2043	962	11	286	286	NUM
admet-2043	962	12	.	.	PUNCT
admet-2043	963	1	https://doi.org/10.1016/j.apsb.2016.05.013	https://doi.org/10.1016/j.apsb.2016.05.013	NOUN
admet-2043	963	2	.	.	PUNCT
admet-2043	964	1	[	[	X
admet-2043	964	2	50	50	NUM
admet-2043	964	3	]	]	PUNCT
admet-2043	964	4	j.	j.	PROPN
admet-2043	964	5	li	li	PROPN
admet-2043	964	6	,	,	PUNCT
admet-2043	964	7	m.	m.	PROPN
admet-2043	964	8	zheng	zheng	PROPN
admet-2043	964	9	,	,	PUNCT
admet-2043	964	10	o.	o.	PROPN
admet-2043	964	11	shimoni	shimoni	PROPN
admet-2043	964	12	,	,	PUNCT
admet-2043	964	13	w.a	w.a	PROPN
admet-2043	964	14	.	.	PROPN
admet-2043	964	15	banks	banks	PROPN
admet-2043	964	16	,	,	PUNCT
admet-2043	964	17	a.i	a.i	PROPN
admet-2043	964	18	.	.	PROPN
admet-2043	964	19	bush	bush	PROPN
admet-2043	964	20	,	,	PUNCT
admet-2043	964	21	j.r	j.r	PROPN
admet-2043	964	22	.	.	PROPN
admet-2043	964	23	gamble	gamble	PROPN
admet-2043	964	24	,	,	PUNCT
admet-2043	964	25	b.	b.	PROPN
admet-2043	964	26	shi	shi	PROPN
admet-2043	964	27	.	.	PUNCT
admet-2043	965	1	development	development	NOUN
admet-2043	965	2	of	of	ADP
admet-2043	965	3	novel	novel	ADJ
admet-2043	965	4	therapeutics	therapeutic	NOUN
admet-2043	965	5	targeting	target	VERB
admet-2043	965	6	the	the	DET
admet-2043	965	7	blood	blood	NOUN
admet-2043	965	8	-	-	PUNCT
admet-2043	965	9	brain	brain	NOUN
admet-2043	965	10	barrier	barrier	NOUN
admet-2043	965	11	:	:	PUNCT
admet-2043	965	12	from	from	ADP
admet-2043	965	13	barrier	barrier	NOUN
admet-2043	965	14	to	to	ADP
admet-2043	965	15	carrier	carrier	NOUN
admet-2043	965	16	.	.	PUNCT
admet-2043	966	1	advanced	advanced	ADJ
admet-2043	966	2	science	science	NOUN
admet-2043	966	3	8	8	NUM
admet-2043	966	4	(	(	PUNCT
admet-2043	966	5	2021	2021	NUM
admet-2043	966	6	)	)	PUNCT
admet-2043	966	7	e2101090	e2101090	VERB
admet-2043	966	8	.	.	PUNCT
admet-2043	966	9	https://doi.org/10.1002/advs.202101090	https://doi.org/10.1002/advs.202101090	X
admet-2043	966	10	.	.	PUNCT
admet-2043	967	1	[	[	X
admet-2043	967	2	51	51	NUM
admet-2043	967	3	]	]	PUNCT
admet-2043	967	4	a.	a.	PROPN
admet-2043	967	5	duro	duro	PROPN
admet-2043	967	6	-	-	PUNCT
admet-2043	967	7	castano	castano	PROPN
admet-2043	967	8	,	,	PUNCT
admet-2043	967	9	d.	d.	PROPN
admet-2043	967	10	moreira	moreira	PROPN
admet-2043	967	11	leite	leite	PROPN
admet-2043	967	12	,	,	PUNCT
admet-2043	967	13	j.	j.	PROPN
admet-2043	967	14	forth	forth	PROPN
admet-2043	967	15	,	,	PUNCT
admet-2043	967	16	y.	y.	PROPN
admet-2043	967	17	deng	deng	PROPN
admet-2043	967	18	,	,	PUNCT
admet-2043	967	19	d.	d.	PROPN
admet-2043	967	20	matias	matias	PROPN
admet-2043	967	21	,	,	PUNCT
admet-2043	967	22	c.	c.	PROPN
admet-2043	967	23	noble	noble	PROPN
admet-2043	967	24	jesus	jesus	PROPN
admet-2043	967	25	,	,	PUNCT
admet-2043	967	26	g.	g.	PROPN
admet-2043	967	27	battaglia	battaglia	PROPN
admet-2043	967	28	.	.	PUNCT
admet-2043	968	1	designing	design	VERB
admet-2043	968	2	peptide	peptide	NOUN
admet-2043	968	3	nanoparticles	nanoparticle	NOUN
admet-2043	968	4	for	for	ADP
admet-2043	968	5	efficient	efficient	ADJ
admet-2043	968	6	brain	brain	NOUN
admet-2043	968	7	delivery	delivery	NOUN
admet-2043	968	8	.	.	PUNCT
admet-2043	969	1	advanced	advanced	ADJ
admet-2043	969	2	drug	drug	NOUN
admet-2043	969	3	delivery	delivery	NOUN
admet-2043	969	4	reviews	review	VERB
admet-2043	969	5	160	160	NUM
admet-2043	969	6	(	(	PUNCT
admet-2043	969	7	2020	2020	NUM
admet-2043	969	8	)	)	PUNCT
admet-2043	969	9	52	52	NUM
admet-2043	969	10	-	-	SYM
admet-2043	969	11	77	77	NUM
admet-2043	969	12	.	.	PUNCT
admet-2043	970	1	https://doi.org/10.1016/j.addr.2020.10.001	https://doi.org/10.1016/j.addr.2020.10.001	VERB
admet-2043	970	2	.	.	PUNCT
admet-2043	971	1	[	[	X
admet-2043	971	2	52	52	NUM
admet-2043	971	3	]	]	PUNCT
admet-2043	971	4	j.	j.	PROPN
admet-2043	971	5	li	li	PROPN
admet-2043	971	6	,	,	PUNCT
admet-2043	971	7	l.	l.	PROPN
admet-2043	971	8	zhou	zhou	PROPN
admet-2043	971	9	,	,	PUNCT
admet-2043	971	10	d.	d.	PROPN
admet-2043	971	11	ye	ye	PROPN
admet-2043	971	12	,	,	PUNCT
admet-2043	971	13	s.	s.	PROPN
admet-2043	971	14	huang	huang	PROPN
admet-2043	971	15	,	,	PUNCT
admet-2043	971	16	k.	k.	PROPN
admet-2043	971	17	shao	shao	PROPN
admet-2043	971	18	,	,	PUNCT
admet-2043	971	19	r.	r.	PROPN
admet-2043	971	20	huang	huang	PROPN
admet-2043	971	21	,	,	PUNCT
admet-2043	971	22	l.	l.	PROPN
admet-2043	971	23	han	han	PROPN
admet-2043	971	24	,	,	PUNCT
admet-2043	971	25	y.	y.	PROPN
admet-2043	971	26	liu	liu	PROPN
admet-2043	971	27	,	,	PUNCT
admet-2043	971	28	s.	s.	PROPN
admet-2043	971	29	liu	liu	PROPN
admet-2043	971	30	,	,	PUNCT
admet-2043	971	31	l.	l.	PROPN
admet-2043	971	32	ye	ye	PROPN
admet-2043	971	33	,	,	PUNCT
admet-2043	971	34	j.	j.	PROPN
admet-2043	971	35	lou	lou	PROPN
admet-2043	971	36	,	,	PUNCT
admet-2043	971	37	c.	c.	PROPN
admet-2043	971	38	jiang	jiang	PROPN
admet-2043	971	39	.	.	PUNCT
admet-2043	972	1	cholinederivate	cholinederivate	ADJ
admet-2043	972	2	-	-	PUNCT
admet-2043	972	3	modified	modify	VERB
admet-2043	972	4	nanoparticles	nanoparticle	NOUN
admet-2043	972	5	for	for	ADP
admet-2043	972	6	brain	brain	NOUN
admet-2043	972	7	-	-	PUNCT
admet-2043	972	8	targeting	target	VERB
admet-2043	972	9	gene	gene	NOUN
admet-2043	972	10	delivery	delivery	NOUN
admet-2043	972	11	.	.	PUNCT
admet-2043	973	1	advanced	advanced	ADJ
admet-2043	973	2	materials	material	NOUN
admet-2043	973	3	23	23	NUM
admet-2043	973	4	(	(	PUNCT
admet-2043	973	5	2011	2011	NUM
admet-2043	973	6	)	)	PUNCT
admet-2043	973	7	4516	4516	NUM
admet-2043	973	8	-	-	SYM
admet-2043	973	9	4520	4520	NUM
admet-2043	973	10	.	.	PUNCT
admet-2043	973	11	https://doi.org/10.1002/adma.201101899	https://doi.org/10.1002/adma.201101899	NOUN
admet-2043	973	12	.	.	PUNCT
admet-2043	974	1	[	[	X
admet-2043	974	2	53	53	NUM
admet-2043	974	3	]	]	PUNCT
admet-2043	974	4	l.	l.	PROPN
admet-2043	974	5	juillerat	juillerat	PROPN
admet-2043	974	6	-	-	PUNCT
admet-2043	974	7	jeanneret	jeanneret	NOUN
admet-2043	974	8	.	.	PUNCT
admet-2043	975	1	the	the	DET
admet-2043	975	2	targeted	target	VERB
admet-2043	975	3	delivery	delivery	NOUN
admet-2043	975	4	of	of	ADP
admet-2043	975	5	cancer	cancer	NOUN
admet-2043	975	6	drugs	drug	NOUN
admet-2043	975	7	across	across	ADP
admet-2043	975	8	the	the	DET
admet-2043	975	9	blood	blood	NOUN
admet-2043	975	10	-	-	PUNCT
admet-2043	975	11	brain	brain	NOUN
admet-2043	975	12	barrier	barrier	NOUN
admet-2043	975	13	:	:	PUNCT
admet-2043	975	14	chemical	chemical	NOUN
admet-2043	975	15	modifications	modification	NOUN
admet-2043	975	16	of	of	ADP
admet-2043	975	17	drugs	drug	NOUN
admet-2043	975	18	or	or	CCONJ
admet-2043	975	19	drug	drug	NOUN
admet-2043	975	20	-	-	PUNCT
admet-2043	975	21	nanoparticles	nanoparticle	NOUN
admet-2043	975	22	?	?	PUNCT
admet-2043	976	1	drug	drug	NOUN
admet-2043	976	2	discovery	discovery	NOUN
admet-2043	976	3	today	today	NOUN
admet-2043	976	4	13	13	NUM
admet-2043	976	5	(	(	PUNCT
admet-2043	976	6	2008	2008	NUM
admet-2043	976	7	)	)	PUNCT
admet-2043	976	8	10991106	10991106	NUM
admet-2043	976	9	.	.	PUNCT
admet-2043	977	1	https://doi.org/10.1016/j.drudis.2008.09.005	https://doi.org/10.1016/j.drudis.2008.09.005	NOUN
admet-2043	977	2	.	.	PUNCT
admet-2043	978	1	[	[	X
admet-2043	978	2	54	54	NUM
admet-2043	978	3	]	]	X
admet-2043	978	4	y.	y.	PROPN
admet-2043	978	5	morofuji	morofuji	PROPN
admet-2043	978	6	,	,	PUNCT
admet-2043	978	7	s.	s.	PROPN
admet-2043	978	8	nakagawa	nakagawa	PROPN
admet-2043	978	9	.	.	PUNCT
admet-2043	979	1	drug	drug	NOUN
admet-2043	979	2	development	development	NOUN
admet-2043	979	3	for	for	ADP
admet-2043	979	4	central	central	ADJ
admet-2043	979	5	nervous	nervous	ADJ
admet-2043	979	6	system	system	NOUN
admet-2043	979	7	diseases	disease	NOUN
admet-2043	979	8	using	use	VERB
admet-2043	979	9	in	in	ADP
admet-2043	979	10	vitro	vitro	X
admet-2043	979	11	blood	blood	NOUN
admet-2043	979	12	-	-	PUNCT
admet-2043	979	13	brain	brain	NOUN
admet-2043	979	14	barrier	barrier	NOUN
admet-2043	979	15	models	model	NOUN
admet-2043	979	16	and	and	CCONJ
admet-2043	979	17	drug	drug	NOUN
admet-2043	979	18	repositioning	repositioning	NOUN
admet-2043	979	19	.	.	PUNCT
admet-2043	980	1	current	current	ADJ
admet-2043	980	2	pharmaceutical	pharmaceutical	ADJ
admet-2043	980	3	design	design	NOUN
admet-2043	980	4	26	26	NUM
admet-2043	980	5	(	(	PUNCT
admet-2043	980	6	2020	2020	NUM
admet-2043	980	7	)	)	PUNCT
admet-2043	980	8	1466	1466	NUM
admet-2043	980	9	-	-	SYM
admet-2043	980	10	1485	1485	NUM
admet-2043	980	11	.	.	PUNCT
admet-2043	981	1	https://doi.org/10.2174/1381612826666200224112534	https://doi.org/10.2174/1381612826666200224112534	NOUN
admet-2043	981	2	.	.	PUNCT
admet-2043	982	1	[	[	X
admet-2043	982	2	55	55	NUM
admet-2043	982	3	]	]	PUNCT
admet-2043	982	4	m.	m.	PROPN
admet-2043	982	5	malhotra	malhotra	PROPN
admet-2043	982	6	,	,	PUNCT
admet-2043	982	7	s.	s.	PROPN
admet-2043	982	8	prakash	prakash	PROPN
admet-2043	982	9	.	.	PUNCT
admet-2043	982	10	targeted	target	VERB
admet-2043	982	11	drug	drug	NOUN
admet-2043	982	12	delivery	delivery	NOUN
admet-2043	982	13	across	across	ADP
admet-2043	982	14	blood	blood	NOUN
admet-2043	982	15	-	-	PUNCT
admet-2043	982	16	brain	brain	NOUN
admet-2043	982	17	-	-	PUNCT
admet-2043	982	18	barrier	barrier	NOUN
admet-2043	982	19	using	use	VERB
admet-2043	982	20	cell	cell	NOUN
admet-2043	982	21	penetrating	penetrate	VERB
admet-2043	982	22	peptides	peptide	NOUN
admet-2043	982	23	tagged	tag	VERB
admet-2043	982	24	nanoparticles	nanoparticle	NOUN
admet-2043	982	25	.	.	PUNCT
admet-2043	983	1	current	current	ADJ
admet-2043	983	2	nanoscience	nanoscience	NOUN
admet-2043	983	3	7	7	NUM
admet-2043	983	4	(	(	PUNCT
admet-2043	983	5	2011	2011	NUM
admet-2043	983	6	)	)	PUNCT
admet-2043	983	7	81	81	NUM
admet-2043	983	8	-	-	SYM
admet-2043	983	9	93	93	NUM
admet-2043	983	10	.	.	PUNCT
admet-2043	984	1	https://doi.org/10.2174/157341311794480336	https://doi.org/10.2174/157341311794480336	NOUN
admet-2043	984	2	.	.	PUNCT
admet-2043	985	1	[	[	X
admet-2043	985	2	56	56	NUM
admet-2043	985	3	]	]	X
admet-2043	985	4	v.m	v.m	PROPN
admet-2043	985	5	.	.	PROPN
admet-2043	985	6	pulgar	pulgar	NOUN
admet-2043	985	7	.	.	PUNCT
admet-2043	986	1	transcytosis	transcytosis	NOUN
admet-2043	986	2	to	to	PART
admet-2043	986	3	cross	cross	VERB
admet-2043	986	4	the	the	DET
admet-2043	986	5	blood	blood	NOUN
admet-2043	986	6	brain	brain	NOUN
admet-2043	986	7	barrier	barrier	NOUN
admet-2043	986	8	,	,	PUNCT
admet-2043	986	9	new	new	ADJ
admet-2043	986	10	advancements	advancement	NOUN
admet-2043	986	11	and	and	CCONJ
admet-2043	986	12	challenges	challenge	NOUN
admet-2043	986	13	.	.	PUNCT
admet-2043	987	1	frontiers	frontier	NOUN
admet-2043	987	2	in	in	ADP
admet-2043	987	3	neuroscience	neuroscience	NOUN
admet-2043	987	4	12	12	NUM
admet-2043	987	5	(	(	PUNCT
admet-2043	987	6	2018	2018	NUM
admet-2043	987	7	)	)	PUNCT
admet-2043	987	8	1019	1019	NUM
admet-2043	987	9	.	.	PUNCT
admet-2043	988	1	https://doi.org/10.3389/fnins.2018.01019	https://doi.org/10.3389/fnins.2018.01019	PROPN
admet-2043	988	2	.	.	PUNCT
admet-2043	989	1	[	[	X
admet-2043	989	2	57	57	NUM
admet-2043	989	3	]	]	X
admet-2043	989	4	s.r	s.r	PROPN
admet-2043	989	5	.	.	PROPN
admet-2043	989	6	elkin	elkin	PROPN
admet-2043	989	7	,	,	PUNCT
admet-2043	989	8	a.m.	a.m.	PROPN
admet-2043	989	9	lakoduk	lakoduk	PROPN
admet-2043	989	10	,	,	PUNCT
admet-2043	989	11	s.l	s.l	PROPN
admet-2043	989	12	.	.	PROPN
admet-2043	989	13	schmid	schmid	PROPN
admet-2043	989	14	.	.	PUNCT
admet-2043	990	1	endocytic	endocytic	ADJ
admet-2043	990	2	pathways	pathway	NOUN
admet-2043	990	3	and	and	CCONJ
admet-2043	990	4	endosomal	endosomal	ADJ
admet-2043	990	5	trafficking	trafficking	NOUN
admet-2043	990	6	:	:	PUNCT
admet-2043	990	7	a	a	DET
admet-2043	990	8	primer	primer	NOUN
admet-2043	990	9	.	.	PUNCT
admet-2043	991	1	wiener	wiener	NOUN
admet-2043	991	2	medizinische	medizinische	PROPN
admet-2043	991	3	wochenschrift	wochenschrift	NOUN
admet-2043	991	4	166	166	NUM
admet-2043	991	5	(	(	PUNCT
admet-2043	991	6	2016	2016	NUM
admet-2043	991	7	)	)	PUNCT
admet-2043	991	8	196	196	NUM
admet-2043	991	9	-	-	SYM
admet-2043	991	10	204	204	NUM
admet-2043	991	11	.	.	PUNCT
admet-2043	992	1	https://doi.org/10.1007/s10354-0160432-7	https://doi.org/10.1007/s10354-0160432-7	PROPN
admet-2043	992	2	.	.	PUNCT
admet-2043	993	1	[	[	X
admet-2043	993	2	58	58	NUM
admet-2043	993	3	]	]	X
admet-2043	993	4	a.r	a.r	PROPN
admet-2043	993	5	.	.	PROPN
admet-2043	993	6	khan	khan	PROPN
admet-2043	993	7	,	,	PUNCT
admet-2043	993	8	x.	x.	PROPN
admet-2043	993	9	yang	yang	PROPN
admet-2043	993	10	,	,	PUNCT
admet-2043	993	11	m.	m.	NOUN
admet-2043	993	12	fu	fu	PROPN
admet-2043	993	13	,	,	PUNCT
admet-2043	993	14	g.	g.	PROPN
admet-2043	993	15	zhai	zhai	PROPN
admet-2043	993	16	.	.	PUNCT
admet-2043	994	1	recent	recent	ADJ
admet-2043	994	2	progress	progress	NOUN
admet-2043	994	3	of	of	ADP
admet-2043	994	4	drug	drug	NOUN
admet-2043	994	5	nanoformulations	nanoformulation	NOUN
admet-2043	994	6	targeting	target	VERB
admet-2043	994	7	to	to	PART
admet-2043	994	8	brain	brain	NOUN
admet-2043	994	9	.	.	PUNCT
admet-2043	995	1	journal	journal	PROPN
admet-2043	995	2	of	of	ADP
admet-2043	995	3	controlled	control	VERB
admet-2043	995	4	release	release	NOUN
admet-2043	995	5	291	291	NUM
admet-2043	995	6	(	(	PUNCT
admet-2043	995	7	2018	2018	NUM
admet-2043	995	8	)	)	PUNCT
admet-2043	995	9	37	37	NUM
admet-2043	995	10	-	-	SYM
admet-2043	995	11	64	64	NUM
admet-2043	995	12	.	.	PUNCT
admet-2043	996	1	https://doi.org/10.1016/j.jconrel.2018.10.004	https://doi.org/10.1016/j.jconrel.2018.10.004	NOUN
admet-2043	996	2	.	.	PUNCT
admet-2043	997	1	[	[	X
admet-2043	997	2	59	59	NUM
admet-2043	997	3	]	]	PUNCT
admet-2043	997	4	m.	m.	NOUN
admet-2043	997	5	azarmi	azarmi	PROPN
admet-2043	997	6	,	,	PUNCT
admet-2043	997	7	h.	h.	PROPN
admet-2043	997	8	maleki	maleki	PROPN
admet-2043	997	9	,	,	PUNCT
admet-2043	997	10	n.	n.	PROPN
admet-2043	997	11	nikkam	nikkam	PROPN
admet-2043	997	12	,	,	PUNCT
admet-2043	997	13	h.	h.	PROPN
admet-2043	997	14	malekinejad	malekinejad	PROPN
admet-2043	997	15	.	.	PUNCT
admet-2043	998	1	transcellular	transcellular	ADJ
admet-2043	998	2	brain	brain	NOUN
admet-2043	998	3	drug	drug	NOUN
admet-2043	998	4	delivery	delivery	NOUN
admet-2043	998	5	:	:	PUNCT
admet-2043	998	6	a	a	DET
admet-2043	998	7	review	review	NOUN
admet-2043	998	8	on	on	ADP
admet-2043	998	9	recent	recent	ADJ
admet-2043	998	10	advancements	advancement	NOUN
admet-2043	998	11	.	.	PUNCT
admet-2043	999	1	international	international	ADJ
admet-2043	999	2	journal	journal	PROPN
admet-2043	999	3	of	of	ADP
admet-2043	999	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	999	5	586	586	NUM
admet-2043	999	6	(	(	PUNCT
admet-2043	999	7	2020	2020	NUM
admet-2043	999	8	)	)	PUNCT
admet-2043	999	9	119582	119582	NUM
admet-2043	999	10	.	.	PUNCT
admet-2043	1000	1	https://doi.org/10.1016/j.ijpharm.2020.119582	https://doi.org/10.1016/j.ijpharm.2020.119582	NOUN
admet-2043	1000	2	.	.	PUNCT
admet-2043	1001	1	[	[	X
admet-2043	1001	2	60	60	NUM
admet-2043	1001	3	]	]	X
admet-2043	1001	4	w.m	w.m	PROPN
admet-2043	1001	5	.	.	PROPN
admet-2043	1001	6	pardridge	pardridge	PROPN
admet-2043	1001	7	,	,	PUNCT
admet-2043	1001	8	r.j	r.j	PROPN
admet-2043	1001	9	.	.	PROPN
admet-2043	1001	10	boado	boado	PROPN
admet-2043	1001	11	,	,	PUNCT
admet-2043	1001	12	y.-s	y.-	NOUN
admet-2043	1001	13	.	.	PUNCT
admet-2043	1002	1	kang	kang	PROPN
admet-2043	1002	2	.	.	PUNCT
admet-2043	1003	1	vector	vector	NOUN
admet-2043	1003	2	-	-	PUNCT
admet-2043	1003	3	mediated	mediate	VERB
admet-2043	1003	4	delivery	delivery	NOUN
admet-2043	1003	5	of	of	ADP
admet-2043	1003	6	a	a	DET
admet-2043	1003	7	polyamide	polyamide	NOUN
admet-2043	1003	8	(	(	PUNCT
admet-2043	1003	9	"	"	PUNCT
admet-2043	1003	10	peptide	peptide	NOUN
admet-2043	1003	11	"	"	PUNCT
admet-2043	1003	12	)	)	PUNCT
admet-2043	1003	13	nucleic	nucleic	ADJ
admet-2043	1003	14	acid	acid	NOUN
admet-2043	1003	15	analogue	analogue	NOUN
admet-2043	1003	16	through	through	ADP
admet-2043	1003	17	the	the	DET
admet-2043	1003	18	blood	blood	NOUN
admet-2043	1003	19	-	-	PUNCT
admet-2043	1003	20	brain	brain	NOUN
admet-2043	1003	21	barrier	barrier	NOUN
admet-2043	1003	22	in	in	ADP
admet-2043	1003	23	vivo	vivo	NOUN
admet-2043	1003	24	.	.	PUNCT
admet-2043	1004	1	pharmacology	pharmacology	NOUN
admet-2043	1004	2	92	92	NUM
admet-2043	1004	3	(	(	PUNCT
admet-2043	1004	4	1995	1995	NUM
admet-2043	1004	5	)	)	PUNCT
admet-2043	1004	6	55925596	55925596	NUM
admet-2043	1004	7	.	.	PUNCT
admet-2043	1005	1	https://doi.org/10.1073%2fpnas.92.12.5592	https://doi.org/10.1073%2fpnas.92.12.5592	NOUN
admet-2043	1005	2	.	.	PUNCT
admet-2043	1006	1	[	[	X
admet-2043	1006	2	61	61	NUM
admet-2043	1006	3	]	]	X
admet-2043	1006	4	c.	c.	NOUN
admet-2043	1006	5	bechara	bechara	PROPN
admet-2043	1006	6	,	,	PUNCT
admet-2043	1006	7	s.	s.	PROPN
admet-2043	1006	8	sagan	sagan	PROPN
admet-2043	1006	9	.	.	PUNCT
admet-2043	1007	1	cell	cell	NOUN
admet-2043	1007	2	-	-	PUNCT
admet-2043	1007	3	penetrating	penetrate	VERB
admet-2043	1007	4	peptides	peptide	NOUN
admet-2043	1007	5	:	:	PUNCT
admet-2043	1007	6	20	20	NUM
admet-2043	1007	7	years	year	NOUN
admet-2043	1007	8	later	later	ADV
admet-2043	1007	9	,	,	PUNCT
admet-2043	1007	10	where	where	SCONJ
admet-2043	1007	11	do	do	AUX
admet-2043	1007	12	we	we	PRON
admet-2043	1007	13	stand	stand	VERB
admet-2043	1007	14	?	?	PUNCT
admet-2043	1008	1	febs	febs	NOUN
admet-2043	1008	2	letters	letter	NOUN
admet-2043	1008	3	587	587	NUM
admet-2043	1008	4	(	(	PUNCT
admet-2043	1008	5	2013	2013	NUM
admet-2043	1008	6	)	)	PUNCT
admet-2043	1008	7	1693	1693	NUM
admet-2043	1008	8	-	-	SYM
admet-2043	1008	9	1702	1702	NUM
admet-2043	1008	10	.	.	PUNCT
admet-2043	1009	1	https://doi.org/10.1016/j.febslet.2013.04.031	https://doi.org/10.1016/j.febslet.2013.04.031	INTJ
admet-2043	1009	2	.	.	PUNCT
admet-2043	1010	1	[	[	X
admet-2043	1010	2	62	62	NUM
admet-2043	1010	3	]	]	X
admet-2043	1010	4	y.	y.	PROPN
admet-2043	1010	5	qin	qin	PROPN
admet-2043	1010	6	,	,	PUNCT
admet-2043	1010	7	h.	h.	PROPN
admet-2043	1010	8	chen	chen	PROPN
admet-2043	1010	9	,	,	PUNCT
admet-2043	1010	10	w.	w.	PROPN
admet-2043	1010	11	yuan	yuan	PROPN
admet-2043	1010	12	,	,	PUNCT
admet-2043	1010	13	r.	r.	PROPN
admet-2043	1010	14	kuai	kuai	PROPN
admet-2043	1010	15	,	,	PUNCT
admet-2043	1010	16	q.	q.	PROPN
admet-2043	1010	17	zhang	zhang	PROPN
admet-2043	1010	18	,	,	PUNCT
admet-2043	1010	19	f.	f.	PROPN
admet-2043	1010	20	xie	xie	PROPN
admet-2043	1010	21	,	,	PUNCT
admet-2043	1010	22	l.	l.	PROPN
admet-2043	1010	23	zhang	zhang	PROPN
admet-2043	1010	24	,	,	PUNCT
admet-2043	1010	25	z.	z.	PROPN
admet-2043	1010	26	zhang	zhang	PROPN
admet-2043	1010	27	,	,	PUNCT
admet-2043	1010	28	j.	j.	PROPN
admet-2043	1010	29	liu	liu	PROPN
admet-2043	1010	30	,	,	PUNCT
admet-2043	1010	31	q.	q.	PROPN
admet-2043	1010	32	he	he	PRON
admet-2043	1010	33	.	.	PUNCT
admet-2043	1011	1	liposome	liposome	VERB
admet-2043	1011	2	formulated	formulate	VERB
admet-2043	1011	3	with	with	ADP
admet-2043	1011	4	tat	tat	NOUN
admet-2043	1011	5	-	-	PUNCT
admet-2043	1011	6	modified	modify	VERB
admet-2043	1011	7	cholesterol	cholesterol	NOUN
admet-2043	1011	8	for	for	ADP
admet-2043	1011	9	enhancing	enhance	VERB
admet-2043	1011	10	the	the	DET
admet-2043	1011	11	brain	brain	NOUN
admet-2043	1011	12	delivery	delivery	NOUN
admet-2043	1011	13	.	.	PUNCT
admet-2043	1012	1	international	international	ADJ
admet-2043	1012	2	journal	journal	PROPN
admet-2043	1012	3	of	of	ADP
admet-2043	1012	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	1012	5	419	419	NUM
admet-2043	1012	6	(	(	PUNCT
admet-2043	1012	7	2011	2011	NUM
admet-2043	1012	8	)	)	PUNCT
admet-2043	1012	9	85	85	NUM
admet-2043	1012	10	-	-	SYM
admet-2043	1012	11	95	95	NUM
admet-2043	1012	12	.	.	PUNCT
admet-2043	1013	1	https://doi.org/10.1016/j.ijpharm.2011.07.021	https://doi.org/10.1016/j.ijpharm.2011.07.021	NUM
admet-2043	1013	2	.	.	PUNCT
admet-2043	1014	1	[	[	X
admet-2043	1014	2	63	63	NUM
admet-2043	1014	3	]	]	PUNCT
admet-2043	1014	4	m.	m.	PROPN
admet-2043	1014	5	malhotra	malhotra	PROPN
admet-2043	1014	6	,	,	PUNCT
admet-2043	1014	7	c.	c.	PROPN
admet-2043	1014	8	tomaro	tomaro	NOUN
admet-2043	1014	9	-	-	PUNCT
admet-2043	1014	10	duchesneau	duchesneau	PROPN
admet-2043	1014	11	,	,	PUNCT
admet-2043	1014	12	s.	s.	PROPN
admet-2043	1014	13	prakash	prakash	PROPN
admet-2043	1014	14	.	.	PUNCT
admet-2043	1014	15	synthesis	synthesis	NOUN
admet-2043	1014	16	of	of	ADP
admet-2043	1014	17	tat	tat	NOUN
admet-2043	1014	18	peptide	peptide	NOUN
admet-2043	1014	19	-	-	PUNCT
admet-2043	1014	20	tagged	tag	VERB
admet-2043	1014	21	pegylated	pegylate	VERB
admet-2043	1014	22	chitosan	chitosan	NOUN
admet-2043	1014	23	nanoparticles	nanoparticle	NOUN
admet-2043	1014	24	for	for	ADP
admet-2043	1014	25	sirna	sirna	PROPN
admet-2043	1014	26	delivery	delivery	NOUN
admet-2043	1014	27	targeting	target	VERB
admet-2043	1014	28	neurodegenerative	neurodegenerative	ADJ
admet-2043	1014	29	diseases	disease	NOUN
admet-2043	1014	30	.	.	PUNCT
admet-2043	1015	1	biomaterials	biomaterial	NOUN
admet-2043	1015	2	34	34	NUM
admet-2043	1015	3	(	(	PUNCT
admet-2043	1015	4	2013	2013	NUM
admet-2043	1015	5	)	)	PUNCT
admet-2043	1015	6	1270	1270	NUM
admet-2043	1015	7	-	-	SYM
admet-2043	1015	8	1280	1280	NUM
admet-2043	1015	9	.	.	PUNCT
admet-2043	1016	1	https://doi.org/10.1016/j.biomaterials.2012.10.013	https://doi.org/10.1016/j.biomaterials.2012.10.013	NOUN
admet-2043	1016	2	.	.	PUNCT
admet-2043	1017	1	[	[	X
admet-2043	1017	2	64	64	NUM
admet-2043	1017	3	]	]	X
admet-2043	1017	4	y.	y.	PROPN
admet-2043	1017	5	cheng	cheng	PROPN
admet-2043	1017	6	,	,	PUNCT
admet-2043	1017	7	q.	q.	PROPN
admet-2043	1017	8	dai	dai	PROPN
admet-2043	1017	9	,	,	PUNCT
admet-2043	1017	10	r.a	r.a	PROPN
admet-2043	1017	11	.	.	PROPN
admet-2043	1017	12	morshed	morshe	VERB
admet-2043	1017	13	,	,	PUNCT
admet-2043	1017	14	x.	x.	PROPN
admet-2043	1017	15	fan	fan	PROPN
admet-2043	1017	16	,	,	PUNCT
admet-2043	1017	17	m.l	m.l	PROPN
admet-2043	1017	18	.	.	PROPN
admet-2043	1017	19	wegscheid	wegscheid	PROPN
admet-2043	1017	20	,	,	PUNCT
admet-2043	1017	21	d.a	d.a	PROPN
admet-2043	1017	22	.	.	PROPN
admet-2043	1017	23	wainwright	wainwright	PROPN
admet-2043	1017	24	,	,	PUNCT
admet-2043	1017	25	y.	y.	PROPN
admet-2043	1017	26	han	han	PROPN
admet-2043	1017	27	,	,	PUNCT
admet-2043	1017	28	l.	l.	PROPN
admet-2043	1017	29	zhang	zhang	PROPN
admet-2043	1017	30	,	,	PUNCT
admet-2043	1017	31	b.	b.	PROPN
admet-2043	1017	32	auffinger	auffinger	PROPN
admet-2043	1017	33	,	,	PUNCT
admet-2043	1017	34	a.l	a.l	PROPN
admet-2043	1017	35	.	.	PROPN
admet-2043	1017	36	tobias	tobias	PROPN
admet-2043	1017	37	,	,	PUNCT
admet-2043	1017	38	e.	e.	PROPN
admet-2043	1017	39	rincon	rincon	PROPN
admet-2043	1017	40	,	,	PUNCT
admet-2043	1017	41	b.	b.	PROPN
admet-2043	1017	42	thaci	thaci	PROPN
admet-2043	1017	43	,	,	PUNCT
admet-2043	1017	44	a.u	a.u	PROPN
admet-2043	1017	45	.	.	PROPN
admet-2043	1017	46	ahmed	ahmed	PROPN
admet-2043	1017	47	,	,	PUNCT
admet-2043	1017	48	p.c	p.c	PROPN
admet-2043	1017	49	.	.	PROPN
admet-2043	1017	50	warnke	warnke	PROPN
admet-2043	1017	51	,	,	PUNCT
admet-2043	1017	52	c.	c.	PROPN
admet-2043	1017	53	he	he	PROPN
admet-2043	1017	54	,	,	PUNCT
admet-2043	1017	55	m.s	m.s	PROPN
admet-2043	1017	56	.	.	PROPN
admet-2043	1017	57	lesniak	lesniak	PROPN
admet-2043	1017	58	.	.	PUNCT
admet-2043	1017	59	bloodbrain	bloodbrain	NOUN
admet-2043	1017	60	barrier	barrier	NOUN
admet-2043	1017	61	permeable	permeable	ADJ
admet-2043	1017	62	gold	gold	NOUN
admet-2043	1017	63	nanoparticles	nanoparticle	NOUN
admet-2043	1017	64	:	:	PUNCT
admet-2043	1017	65	an	an	DET
admet-2043	1017	66	efficient	efficient	ADJ
admet-2043	1017	67	delivery	delivery	NOUN
admet-2043	1017	68	platform	platform	NOUN
admet-2043	1017	69	for	for	ADP
admet-2043	1017	70	enhanced	enhanced	ADJ
admet-2043	1017	71	malignant	malignant	ADJ
admet-2043	1017	72	glioma	glioma	NOUN
admet-2043	1017	73	therapy	therapy	NOUN
admet-2043	1017	74	and	and	CCONJ
admet-2043	1017	75	imaging	imaging	NOUN
admet-2043	1017	76	.	.	PUNCT
admet-2043	1018	1	small	small	ADJ
admet-2043	1018	2	10	10	NUM
admet-2043	1018	3	(	(	PUNCT
admet-2043	1018	4	2014	2014	NUM
admet-2043	1018	5	)	)	PUNCT
admet-2043	1018	6	5137	5137	NUM
admet-2043	1018	7	-	-	SYM
admet-2043	1018	8	5150	5150	NUM
admet-2043	1018	9	.	.	PUNCT
admet-2043	1019	1	https://doi.org/10.1002/smll.201400654	https://doi.org/10.1002/smll.201400654	PROPN
admet-2043	1019	2	.	.	PUNCT
admet-2043	1020	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	X
admet-2043	1021	1	https://doi.org/10.1080/10717544.2018.1494223	https://doi.org/10.1080/10717544.2018.1494223	PROPN
admet-2043	1021	2	https://doi.org/10.1016/j.apsb.2016.05.013	https://doi.org/10.1016/j.apsb.2016.05.013	NUM
admet-2043	1021	3	https://doi.org/10.1002/advs.202101090	https://doi.org/10.1002/advs.202101090	X
admet-2043	1021	4	https://doi.org/10.1016/j.addr.2020.10.001	https://doi.org/10.1016/j.addr.2020.10.001	PROPN
admet-2043	1021	5	https://doi.org/10.1002/adma.201101899	https://doi.org/10.1002/adma.201101899	NOUN
admet-2043	1021	6	https://doi.org/10.1016/j.drudis.2008.09.005	https://doi.org/10.1016/j.drudis.2008.09.005	NOUN
admet-2043	1021	7	https://doi.org/10.2174/1381612826666200224112534	https://doi.org/10.2174/1381612826666200224112534	NOUN
admet-2043	1021	8	https://doi.org/10.2174/157341311794480336	https://doi.org/10.2174/157341311794480336	NOUN
admet-2043	1022	1	https://doi.org/10.3389/fnins.2018.01019	https://doi.org/10.3389/fnins.2018.01019	PROPN
admet-2043	1022	2	https://doi.org/10.1007/s10354-016-0432-7	https://doi.org/10.1007/s10354-016-0432-7	PROPN
admet-2043	1022	3	https://doi.org/10.1007/s10354-016-0432-7	https://doi.org/10.1007/s10354-016-0432-7	NUM
admet-2043	1022	4	https://doi.org/10.1016/j.jconrel.2018.10.004	https://doi.org/10.1016/j.jconrel.2018.10.004	VERB
admet-2043	1022	5	https://doi.org/10.1016/j.ijpharm.2020.119582	https://doi.org/10.1016/j.ijpharm.2020.119582	PROPN
admet-2043	1022	6	https://doi.org/10.1073%2fpnas.92.12.5592	https://doi.org/10.1073%2fpnas.92.12.5592	NOUN
admet-2043	1022	7	https://doi.org/10.1016/j.febslet.2013.04.031	https://doi.org/10.1016/j.febslet.2013.04.031	NUM
admet-2043	1022	8	https://doi.org/10.1016/j.ijpharm.2011.07.021	https://doi.org/10.1016/j.ijpharm.2011.07.021	ADV
admet-2043	1022	9	https://doi.org/10.1016/j.biomaterials.2012.10.013	https://doi.org/10.1016/j.biomaterials.2012.10.013	PROPN
admet-2043	1023	1	https://doi.org/10.1002/smll.201400654	https://doi.org/10.1002/smll.201400654	ADJ
admet-2043	1023	2	m.	m.	NOUN
admet-2043	1023	3	kulkarni	kulkarni	PROPN
admet-2043	1023	4	et	et	PROPN
admet-2043	1023	5	al	al	PROPN
admet-2043	1023	6	.	.	PROPN
admet-2043	1023	7	admet	admet	PROPN
admet-2043	1023	8	&	&	CCONJ
admet-2043	1023	9	dmpk	dmpk	PROPN
admet-2043	1023	10	12(1	12(1	PROPN
admet-2043	1023	11	)	)	PUNCT
admet-2043	1023	12	(	(	PUNCT
admet-2043	1023	13	2024	2024	NUM
admet-2043	1023	14	)	)	PUNCT
admet-2043	1023	15	63	63	NUM
admet-2043	1023	16	-	-	SYM
admet-2043	1023	17	105	105	NUM
admet-2043	1023	18	96	96	NUM
admet-2043	1024	1	[	[	X
admet-2043	1024	2	65	65	NUM
admet-2043	1024	3	]	]	X
admet-2043	1024	4	y.	y.	PROPN
admet-2043	1024	5	qin	qin	PROPN
admet-2043	1024	6	,	,	PUNCT
admet-2043	1024	7	q.	q.	PROPN
admet-2043	1024	8	zhang	zhang	PROPN
admet-2043	1024	9	,	,	PUNCT
admet-2043	1024	10	h.	h.	PROPN
admet-2043	1024	11	chen	chen	PROPN
admet-2043	1024	12	,	,	PUNCT
admet-2043	1024	13	w.	w.	PROPN
admet-2043	1024	14	yuan	yuan	PROPN
admet-2043	1024	15	,	,	PUNCT
admet-2043	1024	16	r.	r.	PROPN
admet-2043	1024	17	kuai	kuai	PROPN
admet-2043	1024	18	,	,	PUNCT
admet-2043	1024	19	f.	f.	PROPN
admet-2043	1024	20	xie	xie	PROPN
admet-2043	1024	21	,	,	PUNCT
admet-2043	1024	22	l.	l.	PROPN
admet-2043	1024	23	zhang	zhang	PROPN
admet-2043	1024	24	,	,	PUNCT
admet-2043	1024	25	x.	x.	PROPN
admet-2043	1024	26	wang	wang	PROPN
admet-2043	1024	27	,	,	PUNCT
admet-2043	1024	28	z.	z.	PROPN
admet-2043	1024	29	zhang	zhang	PROPN
admet-2043	1024	30	,	,	PUNCT
admet-2043	1024	31	j.	j.	PROPN
admet-2043	1024	32	liu	liu	PROPN
admet-2043	1024	33	,	,	PUNCT
admet-2043	1024	34	q.	q.	PROPN
admet-2043	1024	35	he	he	PRON
admet-2043	1024	36	.	.	PUNCT
admet-2043	1025	1	comparison	comparison	NOUN
admet-2043	1025	2	of	of	ADP
admet-2043	1025	3	four	four	NUM
admet-2043	1025	4	different	different	ADJ
admet-2043	1025	5	peptides	peptide	NOUN
admet-2043	1025	6	to	to	PART
admet-2043	1025	7	enhance	enhance	VERB
admet-2043	1025	8	accumulation	accumulation	NOUN
admet-2043	1025	9	of	of	ADP
admet-2043	1025	10	liposomes	liposome	NOUN
admet-2043	1025	11	into	into	ADP
admet-2043	1025	12	the	the	DET
admet-2043	1025	13	brain	brain	NOUN
admet-2043	1025	14	.	.	PUNCT
admet-2043	1026	1	journal	journal	PROPN
admet-2043	1026	2	of	of	ADP
admet-2043	1026	3	drug	drug	NOUN
admet-2043	1026	4	targeting	target	VERB
admet-2043	1026	5	20	20	NUM
admet-2043	1026	6	(	(	PUNCT
admet-2043	1026	7	2012	2012	NUM
admet-2043	1026	8	)	)	PUNCT
admet-2043	1026	9	235	235	NUM
admet-2043	1026	10	-	-	SYM
admet-2043	1026	11	245	245	NUM
admet-2043	1026	12	.	.	PUNCT
admet-2043	1027	1	https://doi.org/10.3109/1061186x.2011.639022	https://doi.org/10.3109/1061186x.2011.639022	PRON
admet-2043	1028	1	[	[	X
admet-2043	1028	2	66	66	NUM
admet-2043	1028	3	]	]	PUNCT
admet-2043	1028	4	e.	e.	PROPN
admet-2043	1028	5	koren	koren	PROPN
admet-2043	1028	6	,	,	PUNCT
admet-2043	1028	7	v.p	v.p	PROPN
admet-2043	1028	8	.	.	PROPN
admet-2043	1028	9	torchilin	torchilin	PROPN
admet-2043	1028	10	.	.	PUNCT
admet-2043	1029	1	cell	cell	NOUN
admet-2043	1029	2	-	-	PUNCT
admet-2043	1029	3	penetrating	penetrate	VERB
admet-2043	1029	4	peptides	peptide	NOUN
admet-2043	1029	5	:	:	PUNCT
admet-2043	1029	6	breaking	break	VERB
admet-2043	1029	7	through	through	ADP
admet-2043	1029	8	to	to	ADP
admet-2043	1029	9	the	the	DET
admet-2043	1029	10	other	other	ADJ
admet-2043	1029	11	side	side	NOUN
admet-2043	1029	12	.	.	PUNCT
admet-2043	1030	1	trends	trend	NOUN
admet-2043	1030	2	in	in	ADP
admet-2043	1030	3	molecular	molecular	ADJ
admet-2043	1030	4	medicine	medicine	NOUN
admet-2043	1030	5	18	18	NUM
admet-2043	1030	6	(	(	PUNCT
admet-2043	1030	7	2012	2012	NUM
admet-2043	1030	8	)	)	PUNCT
admet-2043	1030	9	385	385	NUM
admet-2043	1030	10	-	-	SYM
admet-2043	1030	11	393	393	NUM
admet-2043	1030	12	.	.	PUNCT
admet-2043	1030	13	https://doi.org/10.1016/j.molmed.2012.04.012	https://doi.org/10.1016/j.molmed.2012.04.012	NOUN
admet-2043	1030	14	.	.	PUNCT
admet-2043	1031	1	[	[	X
admet-2043	1031	2	67	67	NUM
admet-2043	1031	3	]	]	X
admet-2043	1031	4	g.	g.	PROPN
admet-2043	1031	5	sharma	sharma	PROPN
admet-2043	1031	6	,	,	PUNCT
admet-2043	1031	7	a.	a.	NOUN
admet-2043	1031	8	modgil	modgil	PROPN
admet-2043	1031	9	,	,	PUNCT
admet-2043	1031	10	c.	c.	PROPN
admet-2043	1031	11	sun	sun	PROPN
admet-2043	1031	12	,	,	PUNCT
admet-2043	1031	13	j.	j.	PROPN
admet-2043	1031	14	singh	singh	PROPN
admet-2043	1031	15	.	.	PUNCT
admet-2043	1032	1	grafting	graft	VERB
admet-2043	1032	2	of	of	ADP
admet-2043	1032	3	cell	cell	NOUN
admet-2043	1032	4	-	-	PUNCT
admet-2043	1032	5	penetrating	penetrate	VERB
admet-2043	1032	6	peptide	peptide	NOUN
admet-2043	1032	7	to	to	ADP
admet-2043	1032	8	receptor	receptor	NOUN
admet-2043	1032	9	-	-	PUNCT
admet-2043	1032	10	targeted	target	VERB
admet-2043	1032	11	liposomes	liposome	NOUN
admet-2043	1032	12	improves	improve	VERB
admet-2043	1032	13	their	their	PRON
admet-2043	1032	14	transfection	transfection	NOUN
admet-2043	1032	15	efficiency	efficiency	NOUN
admet-2043	1032	16	and	and	CCONJ
admet-2043	1032	17	transport	transport	NOUN
admet-2043	1032	18	across	across	ADP
admet-2043	1032	19	blood	blood	NOUN
admet-2043	1032	20	-	-	PUNCT
admet-2043	1032	21	brain	brain	NOUN
admet-2043	1032	22	barrier	barrier	NOUN
admet-2043	1032	23	model	model	NOUN
admet-2043	1032	24	.	.	PUNCT
admet-2043	1033	1	journal	journal	PROPN
admet-2043	1033	2	of	of	ADP
admet-2043	1033	3	pharmaceutical	pharmaceutical	PROPN
admet-2043	1033	4	sciences	science	NOUN
admet-2043	1033	5	101	101	NUM
admet-2043	1033	6	(	(	PUNCT
admet-2043	1033	7	2012	2012	NUM
admet-2043	1033	8	)	)	PUNCT
admet-2043	1033	9	2468	2468	NUM
admet-2043	1033	10	-	-	SYM
admet-2043	1033	11	2478	2478	NUM
admet-2043	1033	12	.	.	PUNCT
admet-2043	1034	1	https://doi.org/10.1002/jps.23152	https://doi.org/10.1002/jps.23152	PROPN
admet-2043	1034	2	.	.	PUNCT
admet-2043	1035	1	[	[	X
admet-2043	1035	2	68	68	NUM
admet-2043	1035	3	]	]	PUNCT
admet-2043	1035	4	g.	g.	PROPN
admet-2043	1035	5	sharma	sharma	PROPN
admet-2043	1035	6	,	,	PUNCT
admet-2043	1035	7	a.	a.	NOUN
admet-2043	1035	8	modgil	modgil	PROPN
admet-2043	1035	9	,	,	PUNCT
admet-2043	1035	10	b.	b.	PROPN
admet-2043	1035	11	layek	layek	PROPN
admet-2043	1035	12	,	,	PUNCT
admet-2043	1035	13	k.	k.	PROPN
admet-2043	1035	14	arora	arora	PROPN
admet-2043	1035	15	,	,	PUNCT
admet-2043	1035	16	c.	c.	PROPN
admet-2043	1035	17	sun	sun	PROPN
admet-2043	1035	18	,	,	PUNCT
admet-2043	1035	19	b.	b.	PROPN
admet-2043	1035	20	law	law	PROPN
admet-2043	1035	21	,	,	PUNCT
admet-2043	1035	22	j.	j.	PROPN
admet-2043	1035	23	singh	singh	PROPN
admet-2043	1035	24	.	.	PUNCT
admet-2043	1036	1	cell	cell	NOUN
admet-2043	1036	2	penetrating	penetrate	VERB
admet-2043	1036	3	peptide	peptide	NOUN
admet-2043	1036	4	tethered	tethered	ADJ
admet-2043	1036	5	bi	bi	ADJ
admet-2043	1036	6	-	-	ADJ
admet-2043	1036	7	ligand	ligand	ADJ
admet-2043	1036	8	liposomes	liposome	NOUN
admet-2043	1036	9	for	for	ADP
admet-2043	1036	10	delivery	delivery	NOUN
admet-2043	1036	11	to	to	PART
admet-2043	1036	12	brain	brain	VERB
admet-2043	1036	13	in	in	ADP
admet-2043	1036	14	vivo	vivo	NOUN
admet-2043	1036	15	:	:	PUNCT
admet-2043	1036	16	biodistribution	biodistribution	NOUN
admet-2043	1036	17	and	and	CCONJ
admet-2043	1036	18	transfection	transfection	NOUN
admet-2043	1036	19	.	.	PUNCT
admet-2043	1037	1	journal	journal	PROPN
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admet-2043	1037	5	167	167	NUM
admet-2043	1037	6	(	(	PUNCT
admet-2043	1037	7	2013	2013	NUM
admet-2043	1037	8	)	)	PUNCT
admet-2043	1037	9	1	1	NUM
admet-2043	1037	10	-	-	SYM
admet-2043	1037	11	10	10	NUM
admet-2043	1037	12	.	.	PUNCT
admet-2043	1038	1	https://doi.org/10.1016/j.jconrel.2013.01.016	https://doi.org/10.1016/j.jconrel.2013.01.016	PRON
admet-2043	1038	2	.	.	PUNCT
admet-2043	1039	1	[	[	X
admet-2043	1039	2	69	69	NUM
admet-2043	1039	3	]	]	X
admet-2043	1039	4	y.	y.	PROPN
admet-2043	1039	5	liu	liu	PROPN
admet-2043	1039	6	,	,	PUNCT
admet-2043	1039	7	r.	r.	PROPN
admet-2043	1039	8	ran	run	VERB
admet-2043	1039	9	,	,	PUNCT
admet-2043	1039	10	j.	j.	PROPN
admet-2043	1039	11	chen	chen	PROPN
admet-2043	1039	12	,	,	PUNCT
admet-2043	1039	13	q.	q.	PROPN
admet-2043	1039	14	kuang	kuang	PROPN
admet-2043	1039	15	,	,	PUNCT
admet-2043	1039	16	j.	j.	PROPN
admet-2043	1039	17	tang	tang	PROPN
admet-2043	1039	18	,	,	PUNCT
admet-2043	1039	19	l.	l.	PROPN
admet-2043	1039	20	mei	mei	PROPN
admet-2043	1039	21	,	,	PUNCT
admet-2043	1039	22	q.	q.	PROPN
admet-2043	1039	23	zhang	zhang	PROPN
admet-2043	1039	24	,	,	PUNCT
admet-2043	1039	25	h.	h.	PROPN
admet-2043	1039	26	gao	gao	PROPN
admet-2043	1039	27	,	,	PUNCT
admet-2043	1039	28	z.	z.	PROPN
admet-2043	1039	29	zhang	zhang	PROPN
admet-2043	1039	30	,	,	PUNCT
admet-2043	1039	31	q.	q.	PROPN
admet-2043	1039	32	he	he	PRON
admet-2043	1039	33	.	.	PUNCT
admet-2043	1040	1	paclitaxel	paclitaxel	PROPN
admet-2043	1040	2	loaded	load	VERB
admet-2043	1040	3	liposomes	liposome	NOUN
admet-2043	1040	4	decorated	decorate	VERB
admet-2043	1040	5	with	with	ADP
admet-2043	1040	6	a	a	DET
admet-2043	1040	7	multifunctional	multifunctional	ADJ
admet-2043	1040	8	tandem	tandem	NOUN
admet-2043	1040	9	peptide	peptide	NOUN
admet-2043	1040	10	for	for	ADP
admet-2043	1040	11	glioma	glioma	NOUN
admet-2043	1040	12	targeting	targeting	NOUN
admet-2043	1040	13	.	.	PUNCT
admet-2043	1041	1	biomaterials	biomaterial	NOUN
admet-2043	1041	2	35	35	NUM
admet-2043	1041	3	(	(	PUNCT
admet-2043	1041	4	2014	2014	NUM
admet-2043	1041	5	)	)	PUNCT
admet-2043	1041	6	4835	4835	NUM
admet-2043	1041	7	-	-	SYM
admet-2043	1041	8	4847	4847	NUM
admet-2043	1041	9	.	.	PUNCT
admet-2043	1042	1	https://doi.org/10.1016/j.biomaterials.2014.02.031	https://doi.org/10.1016/j.biomaterials.2014.02.031	NOUN
admet-2043	1042	2	.	.	PUNCT
admet-2043	1043	1	[	[	X
admet-2043	1043	2	70	70	NUM
admet-2043	1043	3	]	]	X
admet-2043	1043	4	b.r	b.r	PROPN
admet-2043	1043	5	.	.	PROPN
admet-2043	1043	6	meade	meade	PROPN
admet-2043	1043	7	,	,	PUNCT
admet-2043	1043	8	s.f	s.f	PROPN
admet-2043	1043	9	.	.	PROPN
admet-2043	1043	10	dowdy	dowdy	ADJ
admet-2043	1043	11	.	.	PUNCT
admet-2043	1044	1	exogenous	exogenous	ADJ
admet-2043	1044	2	sirna	sirna	PROPN
admet-2043	1044	3	delivery	delivery	NOUN
admet-2043	1044	4	using	use	VERB
admet-2043	1044	5	peptide	peptide	ADJ
admet-2043	1044	6	transduction	transduction	NOUN
admet-2043	1044	7	domains	domain	NOUN
admet-2043	1044	8	/	/	SYM
admet-2043	1044	9	cell	cell	NOUN
admet-2043	1044	10	penetrating	penetrate	VERB
admet-2043	1044	11	peptides	peptide	NOUN
admet-2043	1044	12	.	.	PUNCT
admet-2043	1045	1	advanced	advanced	ADJ
admet-2043	1045	2	drug	drug	NOUN
admet-2043	1045	3	delivery	delivery	NOUN
admet-2043	1045	4	reviews	review	VERB
admet-2043	1045	5	59	59	NUM
admet-2043	1045	6	(	(	PUNCT
admet-2043	1045	7	2007	2007	NUM
admet-2043	1045	8	)	)	PUNCT
admet-2043	1045	9	134	134	NUM
admet-2043	1045	10	-	-	SYM
admet-2043	1045	11	140	140	NUM
admet-2043	1045	12	.	.	PUNCT
admet-2043	1046	1	https://doi.org/10.1016/j.addr.2007.03.004	https://doi.org/10.1016/j.addr.2007.03.004	NOUN
admet-2043	1046	2	.	.	PUNCT
admet-2043	1047	1	[	[	X
admet-2043	1047	2	71	71	NUM
admet-2043	1047	3	]	]	PUNCT
admet-2043	1047	4	m.	m.	NOUN
admet-2043	1047	5	kristensen	kristensen	PROPN
admet-2043	1047	6	,	,	PUNCT
admet-2043	1047	7	h.m	h.m	PROPN
admet-2043	1047	8	.	.	PROPN
admet-2043	1047	9	nielsen	nielsen	PROPN
admet-2043	1047	10	.	.	PUNCT
admet-2043	1047	11	cell	cell	NOUN
admet-2043	1047	12	-	-	PUNCT
admet-2043	1047	13	penetrating	penetrate	VERB
admet-2043	1047	14	peptides	peptide	NOUN
admet-2043	1047	15	as	as	ADP
admet-2043	1047	16	tools	tool	NOUN
admet-2043	1047	17	to	to	PART
admet-2043	1047	18	enhance	enhance	VERB
admet-2043	1047	19	non	non	ADJ
admet-2043	1047	20	-	-	ADJ
admet-2043	1047	21	injectable	injectable	ADJ
admet-2043	1047	22	delivery	delivery	NOUN
admet-2043	1047	23	of	of	ADP
admet-2043	1047	24	biopharmaceuticals	biopharmaceutical	NOUN
admet-2043	1047	25	.	.	PUNCT
admet-2043	1048	1	tissue	tissue	NOUN
admet-2043	1048	2	barriers	barrier	NOUN
admet-2043	1048	3	4	4	NUM
admet-2043	1048	4	(	(	PUNCT
admet-2043	1048	5	2016	2016	NUM
admet-2043	1048	6	)	)	PUNCT
admet-2043	1048	7	e1178369	e1178369	PROPN
admet-2043	1048	8	.	.	PUNCT
admet-2043	1049	1	https://doi.org/10.1080%2f21688370.2016.1178369	https://doi.org/10.1080%2f21688370.2016.1178369	PROPN
admet-2043	1049	2	.	.	PUNCT
admet-2043	1050	1	[	[	X
admet-2043	1050	2	72	72	NUM
admet-2043	1050	3	]	]	X
admet-2043	1050	4	a.m.	a.m.	NOUN
admet-2043	1050	5	api	api	PROPN
admet-2043	1050	6	,	,	PUNCT
admet-2043	1050	7	d.	d.	PROPN
admet-2043	1050	8	belsito	belsito	PROPN
admet-2043	1050	9	,	,	PUNCT
admet-2043	1050	10	s.	s.	PROPN
admet-2043	1050	11	bhatia	bhatia	PROPN
admet-2043	1050	12	,	,	PUNCT
admet-2043	1050	13	m.	m.	NOUN
admet-2043	1050	14	bruze	bruze	PROPN
admet-2043	1050	15	,	,	PUNCT
admet-2043	1050	16	p.	p.	NOUN
admet-2043	1050	17	calow	calow	NOUN
admet-2043	1050	18	,	,	PUNCT
admet-2043	1050	19	m.l	m.l	PROPN
admet-2043	1050	20	.	.	PROPN
admet-2043	1050	21	dagli	dagli	PROPN
admet-2043	1050	22	,	,	PUNCT
admet-2043	1050	23	w.	w.	PROPN
admet-2043	1050	24	dekant	dekant	PROPN
admet-2043	1050	25	,	,	PUNCT
admet-2043	1050	26	a.d	a.d	PROPN
admet-2043	1050	27	.	.	PROPN
admet-2043	1050	28	fryer	fryer	PROPN
admet-2043	1050	29	,	,	PUNCT
admet-2043	1050	30	l.	l.	PROPN
admet-2043	1050	31	kromidas	kromidas	PROPN
admet-2043	1050	32	,	,	PUNCT
admet-2043	1050	33	s.	s.	PROPN
admet-2043	1050	34	la	la	PROPN
admet-2043	1050	35	cava	cava	PROPN
admet-2043	1050	36	,	,	PUNCT
admet-2043	1050	37	j.f	j.f	PROPN
admet-2043	1050	38	.	.	PROPN
admet-2043	1050	39	lalko	lalko	PROPN
admet-2043	1050	40	,	,	PUNCT
admet-2043	1050	41	a.	a.	PROPN
admet-2043	1050	42	lapczynski	lapczynski	PROPN
admet-2043	1050	43	,	,	PUNCT
admet-2043	1050	44	d.c	d.c	PROPN
admet-2043	1050	45	.	.	PROPN
admet-2043	1050	46	liebler	liebler	PROPN
admet-2043	1050	47	,	,	PUNCT
admet-2043	1050	48	y.	y.	PROPN
admet-2043	1050	49	miyachi	miyachi	PROPN
admet-2043	1050	50	,	,	PUNCT
admet-2043	1050	51	v.t	v.t	PROPN
admet-2043	1050	52	.	.	PROPN
admet-2043	1050	53	politano	politano	PROPN
admet-2043	1050	54	,	,	PUNCT
admet-2043	1050	55	g.	g.	PROPN
admet-2043	1050	56	ritacco	ritacco	PROPN
admet-2043	1050	57	,	,	PUNCT
admet-2043	1050	58	d.	d.	PROPN
admet-2043	1050	59	salvito	salvito	PROPN
admet-2043	1050	60	,	,	PUNCT
admet-2043	1050	61	j.	j.	PROPN
admet-2043	1050	62	shen	shen	PROPN
admet-2043	1050	63	,	,	PUNCT
admet-2043	1050	64	t.w	t.w	PROPN
admet-2043	1050	65	.	.	PROPN
admet-2043	1050	66	schultz	schultz	PROPN
admet-2043	1050	67	,	,	PUNCT
admet-2043	1050	68	i.g	i.g	PROPN
admet-2043	1050	69	.	.	PROPN
admet-2043	1050	70	sipes	sipes	PROPN
admet-2043	1050	71	,	,	PUNCT
admet-2043	1050	72	b.	b.	PROPN
admet-2043	1050	73	wall	wall	PROPN
admet-2043	1050	74	,	,	PUNCT
admet-2043	1050	75	d.k	d.k	PROPN
admet-2043	1050	76	.	.	PROPN
admet-2043	1050	77	wilcox	wilcox	PROPN
admet-2043	1050	78	.	.	PUNCT
admet-2043	1051	1	rifm	rifm	PROPN
admet-2043	1051	2	fragrance	fragrance	NOUN
admet-2043	1051	3	ingredient	ingredient	NOUN
admet-2043	1051	4	safety	safety	NOUN
admet-2043	1051	5	assessment	assessment	NOUN
admet-2043	1051	6	,	,	PUNCT
admet-2043	1051	7	lborneol	lborneol	NOUN
admet-2043	1051	8	,	,	PUNCT
admet-2043	1051	9	cas	cas	PROPN
admet-2043	1051	10	registry	registry	PROPN
admet-2043	1051	11	number	number	PROPN
admet-2043	1051	12	464	464	NUM
admet-2043	1051	13	-	-	SYM
admet-2043	1051	14	45	45	NUM
admet-2043	1051	15	-	-	SYM
admet-2043	1051	16	9	9	NUM
admet-2043	1051	17	.	.	PUNCT
admet-2043	1052	1	food	food	NOUN
admet-2043	1052	2	and	and	CCONJ
admet-2043	1052	3	chemical	chemical	NOUN
admet-2043	1052	4	toxicology	toxicology	NOUN
admet-2043	1052	5	82	82	NUM
admet-2043	1052	6	suppl	suppl	ADJ
admet-2043	1052	7	(	(	PUNCT
admet-2043	1052	8	2015	2015	NUM
admet-2043	1052	9	)	)	PUNCT
admet-2043	1052	10	s74	s74	NOUN
admet-2043	1052	11	-	-	PUNCT
admet-2043	1052	12	80	80	NUM
admet-2043	1052	13	.	.	PUNCT
admet-2043	1053	1	https://doi.org/10.1016/j.fct.2015.04.013	https://doi.org/10.1016/j.fct.2015.04.013	PROPN
admet-2043	1053	2	.	.	PUNCT
admet-2043	1054	1	[	[	X
admet-2043	1054	2	73	73	NUM
admet-2043	1054	3	]	]	PUNCT
admet-2043	1054	4	p.	p.	PROPN
admet-2043	1054	5	toman	toman	PROPN
admet-2043	1054	6	,	,	PUNCT
admet-2043	1054	7	c.f	c.f	PROPN
admet-2043	1054	8	.	.	PROPN
admet-2043	1054	9	lien	lien	PROPN
admet-2043	1054	10	,	,	PUNCT
admet-2043	1054	11	z.	z.	PROPN
admet-2043	1054	12	ahmad	ahmad	PROPN
admet-2043	1054	13	,	,	PUNCT
admet-2043	1054	14	s.	s.	PROPN
admet-2043	1054	15	dietrich	dietrich	PROPN
admet-2043	1054	16	,	,	PUNCT
admet-2043	1054	17	j.r	j.r	PROPN
admet-2043	1054	18	.	.	PROPN
admet-2043	1054	19	smith	smith	PROPN
admet-2043	1054	20	,	,	PUNCT
admet-2043	1054	21	q.	q.	PROPN
admet-2043	1054	22	an	an	PROPN
admet-2043	1054	23	,	,	PUNCT
admet-2043	1054	24	e.	e.	PROPN
admet-2043	1054	25	molnar	molnar	PROPN
admet-2043	1054	26	,	,	PUNCT
admet-2043	1054	27	g.j	g.j	PROPN
admet-2043	1054	28	.	.	PROPN
admet-2043	1054	29	pilkington	pilkington	PROPN
admet-2043	1054	30	,	,	PUNCT
admet-2043	1054	31	d.c	d.c	PROPN
admet-2043	1054	32	.	.	PROPN
admet-2043	1054	33	gorecki	gorecki	PROPN
admet-2043	1054	34	,	,	PUNCT
admet-2043	1054	35	j.	j.	PROPN
admet-2043	1054	36	tsibouklis	tsibouklis	PROPN
admet-2043	1054	37	,	,	PUNCT
admet-2043	1054	38	e.	e.	PROPN
admet-2043	1054	39	barbu	barbu	PROPN
admet-2043	1054	40	.	.	PUNCT
admet-2043	1055	1	nanoparticles	nanoparticle	NOUN
admet-2043	1055	2	of	of	ADP
admet-2043	1055	3	alkylglyceryl	alkylglyceryl	NOUN
admet-2043	1055	4	-	-	PUNCT
admet-2043	1055	5	dextran	dextran	NOUN
admet-2043	1055	6	-	-	PUNCT
admet-2043	1055	7	graft	graft	NOUN
admet-2043	1055	8	-	-	PUNCT
admet-2043	1055	9	poly(lactic	poly(lactic	NOUN
admet-2043	1055	10	acid	acid	NOUN
admet-2043	1055	11	)	)	PUNCT
admet-2043	1055	12	for	for	ADP
admet-2043	1055	13	drug	drug	NOUN
admet-2043	1055	14	delivery	delivery	NOUN
admet-2043	1055	15	to	to	ADP
admet-2043	1055	16	the	the	DET
admet-2043	1055	17	brain	brain	NOUN
admet-2043	1055	18	:	:	PUNCT
admet-2043	1055	19	preparation	preparation	NOUN
admet-2043	1055	20	and	and	CCONJ
admet-2043	1055	21	in	in	ADP
admet-2043	1055	22	vitro	vitro	X
admet-2043	1055	23	investigation	investigation	NOUN
admet-2043	1055	24	.	.	PUNCT
admet-2043	1056	1	acta	acta	PROPN
admet-2043	1056	2	biomaterialia	biomaterialia	PROPN
admet-2043	1056	3	23	23	NUM
admet-2043	1056	4	(	(	PUNCT
admet-2043	1056	5	2015	2015	NUM
admet-2043	1056	6	)	)	PUNCT
admet-2043	1056	7	250	250	NUM
admet-2043	1056	8	-	-	SYM
admet-2043	1056	9	262	262	NUM
admet-2043	1056	10	.	.	PUNCT
admet-2043	1057	1	https://doi.org/10.1016/j.actbio.2015.05.009	https://doi.org/10.1016/j.actbio.2015.05.009	NOUN
admet-2043	1057	2	.	.	PUNCT
admet-2043	1058	1	[	[	X
admet-2043	1058	2	74	74	NUM
admet-2043	1058	3	]	]	PUNCT
admet-2043	1058	4	a.m.	a.m.	NOUN
admet-2043	1058	5	grabrucker	grabrucker	PROPN
admet-2043	1058	6	,	,	PUNCT
admet-2043	1058	7	r.	r.	PROPN
admet-2043	1058	8	chhabra	chhabra	PROPN
admet-2043	1058	9	,	,	PUNCT
admet-2043	1058	10	d.	d.	PROPN
admet-2043	1058	11	belletti	belletti	PROPN
admet-2043	1058	12	,	,	PUNCT
admet-2043	1058	13	f.	f.	PROPN
admet-2043	1058	14	forni	forni	PROPN
admet-2043	1058	15	,	,	PUNCT
admet-2043	1058	16	m.a	m.a	PROPN
admet-2043	1058	17	.	.	PROPN
admet-2043	1058	18	vandelli	vandelli	PROPN
admet-2043	1058	19	,	,	PUNCT
admet-2043	1058	20	b.	b.	PROPN
admet-2043	1058	21	ruozi	ruozi	PROPN
admet-2043	1058	22	,	,	PUNCT
admet-2043	1058	23	g.	g.	PROPN
admet-2043	1058	24	tosi	tosi	PROPN
admet-2043	1058	25	,	,	PUNCT
admet-2043	1058	26	nanoparticles	nanoparticle	NOUN
admet-2043	1058	27	as	as	ADP
admet-2043	1058	28	blood	blood	NOUN
admet-2043	1058	29	–	–	PUNCT
admet-2043	1058	30	brain	brain	NOUN
admet-2043	1058	31	barrier	barrier	NOUN
admet-2043	1058	32	permeable	permeable	ADJ
admet-2043	1058	33	cns	cns	NOUN
admet-2043	1058	34	targeted	target	VERB
admet-2043	1058	35	drug	drug	NOUN
admet-2043	1058	36	delivery	delivery	NOUN
admet-2043	1058	37	systems	system	NOUN
admet-2043	1058	38	,	,	PUNCT
admet-2043	1058	39	in	in	ADP
admet-2043	1058	40	the	the	DET
admet-2043	1058	41	blood	blood	NOUN
admet-2043	1058	42	brain	brain	NOUN
admet-2043	1058	43	barrier	barrier	NOUN
admet-2043	1058	44	(	(	PUNCT
admet-2043	1058	45	bbb	bbb	PROPN
admet-2043	1058	46	)	)	PUNCT
admet-2043	1058	47	,	,	PUNCT
admet-2043	1058	48	springer2014	springer2014	PROPN
admet-2043	1058	49	,	,	PUNCT
admet-2043	1058	50	p.	p.	NOUN
admet-2043	1058	51	71	71	NUM
admet-2043	1058	52	-	-	SYM
admet-2043	1058	53	89	89	NUM
admet-2043	1058	54	3662437864	3662437864	NUM
admet-2043	1058	55	.	.	PUNCT
admet-2043	1059	1	https://doi.org/10.1007/7355_2013_22	https://doi.org/10.1007/7355_2013_22	NOUN
admet-2043	1060	1	[	[	X
admet-2043	1060	2	75	75	NUM
admet-2043	1060	3	]	]	X
admet-2043	1060	4	t.w	t.w	PROPN
admet-2043	1060	5	.	.	PROPN
admet-2043	1060	6	schultz	schultz	PROPN
admet-2043	1060	7	,	,	PUNCT
admet-2043	1060	8	r.e	r.e	PROPN
admet-2043	1060	9	.	.	PROPN
admet-2043	1060	10	carlson	carlson	PROPN
admet-2043	1060	11	,	,	PUNCT
admet-2043	1060	12	m.t	m.t	PROPN
admet-2043	1060	13	.	.	PROPN
admet-2043	1060	14	cronin	cronin	PROPN
admet-2043	1060	15	,	,	PUNCT
admet-2043	1060	16	j.l	j.l	PROPN
admet-2043	1060	17	.	.	PROPN
admet-2043	1060	18	hermens	hermens	PROPN
admet-2043	1060	19	,	,	PUNCT
admet-2043	1060	20	r.	r.	PROPN
admet-2043	1060	21	johnson	johnson	PROPN
admet-2043	1060	22	,	,	PUNCT
admet-2043	1060	23	p.j	p.j	PROPN
admet-2043	1060	24	.	.	PROPN
admet-2043	1060	25	o'brien	o'brien	PROPN
admet-2043	1060	26	,	,	PUNCT
admet-2043	1060	27	d.w	d.w	PROPN
admet-2043	1060	28	.	.	PROPN
admet-2043	1060	29	roberts	roberts	PROPN
admet-2043	1060	30	,	,	PUNCT
admet-2043	1060	31	a.	a.	PROPN
admet-2043	1060	32	siraki	siraki	PROPN
admet-2043	1060	33	,	,	PUNCT
admet-2043	1060	34	k.b	k.b	PROPN
admet-2043	1060	35	.	.	PROPN
admet-2043	1060	36	wallace	wallace	PROPN
admet-2043	1060	37	,	,	PUNCT
admet-2043	1060	38	g.d	g.d	PROPN
admet-2043	1060	39	.	.	PROPN
admet-2043	1060	40	veith	veith	PROPN
admet-2043	1060	41	.	.	PUNCT
admet-2043	1061	1	a	a	DET
admet-2043	1061	2	conceptual	conceptual	ADJ
admet-2043	1061	3	framework	framework	NOUN
admet-2043	1061	4	for	for	ADP
admet-2043	1061	5	predicting	predict	VERB
admet-2043	1061	6	the	the	DET
admet-2043	1061	7	toxicity	toxicity	NOUN
admet-2043	1061	8	of	of	ADP
admet-2043	1061	9	reactive	reactive	ADJ
admet-2043	1061	10	chemicals	chemical	NOUN
admet-2043	1061	11	:	:	PUNCT
admet-2043	1061	12	modeling	model	VERB
admet-2043	1061	13	soft	soft	ADJ
admet-2043	1061	14	electrophilicity	electrophilicity	NOUN
admet-2043	1061	15	.	.	PUNCT
admet-2043	1062	1	sar	sar	PROPN
admet-2043	1062	2	and	and	CCONJ
admet-2043	1062	3	qsar	qsar	VERB
admet-2043	1062	4	in	in	ADP
admet-2043	1062	5	environmental	environmental	ADJ
admet-2043	1062	6	research	research	NOUN
admet-2043	1062	7	17	17	NUM
admet-2043	1062	8	(	(	PUNCT
admet-2043	1062	9	2006	2006	NUM
admet-2043	1062	10	)	)	PUNCT
admet-2043	1062	11	413428	413428	NUM
admet-2043	1062	12	.	.	PUNCT
admet-2043	1063	1	https://doi.org/10.1080/10629360600884371	https://doi.org/10.1080/10629360600884371	X
admet-2043	1063	2	.	.	PUNCT
admet-2043	1064	1	[	[	X
admet-2043	1064	2	76	76	NUM
admet-2043	1064	3	]	]	X
admet-2043	1064	4	k.a	k.a	PROPN
admet-2043	1064	5	.	.	PROPN
admet-2043	1064	6	jacobson	jacobson	PROPN
admet-2043	1064	7	,	,	PUNCT
admet-2043	1064	8	z.g	z.g	PROPN
admet-2043	1064	9	.	.	PUNCT
admet-2043	1065	1	gao	gao	PROPN
admet-2043	1065	2	.	.	PUNCT
admet-2043	1065	3	adenosine	adenosine	NOUN
admet-2043	1065	4	receptors	receptor	NOUN
admet-2043	1065	5	as	as	ADP
admet-2043	1065	6	therapeutic	therapeutic	ADJ
admet-2043	1065	7	targets	target	NOUN
admet-2043	1065	8	.	.	PUNCT
admet-2043	1066	1	nature	nature	NOUN
admet-2043	1066	2	reviews	review	VERB
admet-2043	1066	3	drug	drug	NOUN
admet-2043	1066	4	discovery	discovery	NOUN
admet-2043	1066	5	5	5	NUM
admet-2043	1066	6	(	(	PUNCT
admet-2043	1066	7	2006	2006	NUM
admet-2043	1066	8	)	)	PUNCT
admet-2043	1066	9	247	247	NUM
admet-2043	1066	10	-	-	SYM
admet-2043	1066	11	264	264	NUM
admet-2043	1066	12	.	.	PUNCT
admet-2043	1067	1	https://doi.org/10.1038/nrd1983	https://doi.org/10.1038/nrd1983	ADJ
admet-2043	1067	2	.	.	PUNCT
admet-2043	1068	1	[	[	X
admet-2043	1068	2	77	77	NUM
admet-2043	1068	3	]	]	X
admet-2043	1068	4	s.	s.	PROPN
admet-2043	1068	5	sachdeva	sachdeva	PROPN
admet-2043	1068	6	,	,	PUNCT
admet-2043	1068	7	m.	m.	NOUN
admet-2043	1068	8	gupta	gupta	PROPN
admet-2043	1068	9	.	.	PUNCT
admet-2043	1068	10	adenosine	adenosine	NOUN
admet-2043	1068	11	and	and	CCONJ
admet-2043	1068	12	its	its	PRON
admet-2043	1068	13	receptors	receptor	NOUN
admet-2043	1068	14	as	as	ADP
admet-2043	1068	15	therapeutic	therapeutic	ADJ
admet-2043	1068	16	targets	target	NOUN
admet-2043	1068	17	:	:	PUNCT
admet-2043	1068	18	an	an	DET
admet-2043	1068	19	overview	overview	NOUN
admet-2043	1068	20	.	.	PUNCT
admet-2043	1069	1	saudi	saudi	ADJ
admet-2043	1069	2	pharmaceutical	pharmaceutical	PROPN
admet-2043	1069	3	journal	journal	NOUN
admet-2043	1069	4	21	21	NUM
admet-2043	1069	5	(	(	PUNCT
admet-2043	1069	6	2013	2013	NUM
admet-2043	1069	7	)	)	PUNCT
admet-2043	1069	8	245	245	NUM
admet-2043	1069	9	-	-	SYM
admet-2043	1069	10	253	253	NUM
admet-2043	1069	11	.	.	PUNCT
admet-2043	1070	1	https://doi.org/10.1016/j.jsps.2012.05.011	https://doi.org/10.1016/j.jsps.2012.05.011	PROPN
admet-2043	1070	2	.	.	PUNCT
admet-2043	1071	1	[	[	X
admet-2043	1071	2	78	78	NUM
admet-2043	1071	3	]	]	X
admet-2043	1071	4	a.j	a.j	PROPN
admet-2043	1071	5	.	.	PROPN
admet-2043	1071	6	carman	carman	PROPN
admet-2043	1071	7	,	,	PUNCT
admet-2043	1071	8	j.h	j.h	PROPN
admet-2043	1071	9	.	.	PROPN
admet-2043	1071	10	mills	mills	PROPN
admet-2043	1071	11	,	,	PUNCT
admet-2043	1071	12	a.	a.	NOUN
admet-2043	1071	13	krenz	krenz	PROPN
admet-2043	1071	14	,	,	PUNCT
admet-2043	1071	15	d.g	d.g	PROPN
admet-2043	1071	16	.	.	PROPN
admet-2043	1071	17	kim	kim	PROPN
admet-2043	1071	18	,	,	PUNCT
admet-2043	1071	19	m.s	m.s	PROPN
admet-2043	1071	20	.	.	PROPN
admet-2043	1071	21	bynoe	bynoe	PROPN
admet-2043	1071	22	.	.	PUNCT
admet-2043	1072	1	adenosine	adenosine	ADJ
admet-2043	1072	2	receptor	receptor	NOUN
admet-2043	1072	3	signaling	signal	VERB
admet-2043	1072	4	modulates	modulate	NOUN
admet-2043	1072	5	permeability	permeability	NOUN
admet-2043	1072	6	of	of	ADP
admet-2043	1072	7	the	the	DET
admet-2043	1072	8	blood	blood	NOUN
admet-2043	1072	9	-	-	PUNCT
admet-2043	1072	10	brain	brain	NOUN
admet-2043	1072	11	barrier	barrier	NOUN
admet-2043	1072	12	.	.	PUNCT
admet-2043	1073	1	journal	journal	NOUN
admet-2043	1073	2	of	of	ADP
admet-2043	1073	3	neuroscience	neuroscience	NOUN
admet-2043	1073	4	31	31	NUM
admet-2043	1073	5	(	(	PUNCT
admet-2043	1073	6	2011	2011	NUM
admet-2043	1073	7	)	)	PUNCT
admet-2043	1073	8	13272	13272	NUM
admet-2043	1073	9	-	-	SYM
admet-2043	1073	10	13280	13280	NUM
admet-2043	1073	11	.	.	PUNCT
admet-2043	1074	1	https://doi.org/10.1523/jneurosci.3337-11.2011	https://doi.org/10.1523/jneurosci.3337-11.2011	PROPN
admet-2043	1074	2	.	.	PUNCT
admet-2043	1075	1	[	[	X
admet-2043	1075	2	79	79	NUM
admet-2043	1075	3	]	]	PUNCT
admet-2043	1075	4	x.	x.	NOUN
admet-2043	1075	5	gao	gao	PROPN
admet-2043	1075	6	,	,	PUNCT
admet-2043	1075	7	j.	j.	PROPN
admet-2043	1075	8	qian	qian	PROPN
admet-2043	1075	9	,	,	PUNCT
admet-2043	1075	10	s.	s.	PROPN
admet-2043	1075	11	zheng	zheng	PROPN
admet-2043	1075	12	,	,	PUNCT
admet-2043	1075	13	y.	y.	PROPN
admet-2043	1075	14	changyi	changyi	PROPN
admet-2043	1075	15	,	,	PUNCT
admet-2043	1075	16	j.	j.	PROPN
admet-2043	1075	17	zhang	zhang	PROPN
admet-2043	1075	18	,	,	PUNCT
admet-2043	1075	19	s.	s.	PROPN
admet-2043	1075	20	ju	ju	PROPN
admet-2043	1075	21	,	,	PUNCT
admet-2043	1075	22	j.	j.	PROPN
admet-2043	1075	23	zhu	zhu	PROPN
admet-2043	1075	24	,	,	PUNCT
admet-2043	1075	25	c.	c.	PROPN
admet-2043	1075	26	li	li	PROPN
admet-2043	1075	27	.	.	PUNCT
admet-2043	1075	28	overcoming	overcome	VERB
admet-2043	1075	29	the	the	DET
admet-2043	1075	30	blood	blood	NOUN
admet-2043	1075	31	-	-	PUNCT
admet-2043	1075	32	brain	brain	NOUN
admet-2043	1075	33	barrier	barrier	NOUN
admet-2043	1075	34	for	for	ADP
admet-2043	1075	35	delivering	deliver	VERB
admet-2043	1075	36	drugs	drug	NOUN
admet-2043	1075	37	into	into	ADP
admet-2043	1075	38	the	the	DET
admet-2043	1075	39	brain	brain	NOUN
admet-2043	1075	40	by	by	ADP
admet-2043	1075	41	using	use	VERB
admet-2043	1075	42	adenosine	adenosine	ADJ
admet-2043	1075	43	receptor	receptor	NOUN
admet-2043	1075	44	nanoagonist	nanoagonist	NOUN
admet-2043	1075	45	.	.	PUNCT
admet-2043	1076	1	acs	acs	PROPN
admet-2043	1076	2	nano	nano	VERB
admet-2043	1076	3	8	8	NUM
admet-2043	1076	4	(	(	PUNCT
admet-2043	1076	5	2014	2014	NUM
admet-2043	1076	6	)	)	PUNCT
admet-2043	1076	7	3678	3678	NUM
admet-2043	1076	8	-	-	SYM
admet-2043	1076	9	3689	3689	NUM
admet-2043	1076	10	.	.	PUNCT
admet-2043	1077	1	https://doi.org/10.1021/nn5003375	https://doi.org/10.1021/nn5003375	X
admet-2043	1077	2	.	.	PUNCT
admet-2043	1078	1	[	[	X
admet-2043	1078	2	80	80	NUM
admet-2043	1078	3	]	]	X
admet-2043	1078	4	w.	w.	PROPN
admet-2043	1078	5	liang	liang	PROPN
admet-2043	1078	6	,	,	PUNCT
admet-2043	1078	7	w.	w.	PROPN
admet-2043	1078	8	xu	xu	PROPN
admet-2043	1078	9	,	,	PUNCT
admet-2043	1078	10	j.	j.	PROPN
admet-2043	1078	11	zhu	zhu	PROPN
admet-2043	1078	12	,	,	PUNCT
admet-2043	1078	13	y.	y.	PROPN
admet-2043	1078	14	zhu	zhu	PROPN
admet-2043	1078	15	,	,	PUNCT
admet-2043	1078	16	q.	q.	PROPN
admet-2043	1078	17	gu	gu	PROPN
admet-2043	1078	18	,	,	PUNCT
admet-2043	1078	19	y.	y.	PROPN
admet-2043	1078	20	li	li	PROPN
admet-2043	1078	21	,	,	PUNCT
admet-2043	1078	22	c.	c.	PROPN
admet-2043	1078	23	guo	guo	PROPN
admet-2043	1078	24	,	,	PUNCT
admet-2043	1078	25	y.	y.	PROPN
admet-2043	1078	26	huang	huang	PROPN
admet-2043	1078	27	,	,	PUNCT
admet-2043	1078	28	j.	j.	PROPN
admet-2043	1078	29	yu	yu	PROPN
admet-2043	1078	30	,	,	PUNCT
admet-2043	1078	31	w.	w.	PROPN
admet-2043	1078	32	wang	wang	PROPN
admet-2043	1078	33	,	,	PUNCT
admet-2043	1078	34	y.	y.	PROPN
admet-2043	1078	35	hu	hu	PROPN
admet-2043	1078	36	,	,	PUNCT
admet-2043	1078	37	y.	y.	PROPN
admet-2043	1078	38	zhao	zhao	PROPN
admet-2043	1078	39	,	,	PUNCT
admet-2043	1078	40	b.	b.	PROPN
admet-2043	1078	41	han	han	PROPN
admet-2043	1078	42	,	,	PUNCT
admet-2043	1078	43	w.	w.	PROPN
admet-2043	1078	44	bei	bei	PROPN
admet-2043	1078	45	,	,	PUNCT
admet-2043	1078	46	j.	j.	PROPN
admet-2043	1078	47	guo	guo	PROPN
admet-2043	1078	48	.	.	PUNCT
admet-2043	1078	49	ginkgo	ginkgo	NOUN
admet-2043	1078	50	biloba	biloba	PROPN
admet-2043	1078	51	extract	extract	NOUN
admet-2043	1078	52	improves	improve	VERB
admet-2043	1078	53	brain	brain	NOUN
admet-2043	1078	54	uptake	uptake	NOUN
admet-2043	1078	55	of	of	ADP
admet-2043	1078	56	ginsenosides	ginsenoside	NOUN
admet-2043	1078	57	by	by	ADP
admet-2043	1078	58	increasing	increase	VERB
admet-2043	1078	59	bloodbrain	bloodbrain	NOUN
admet-2043	1078	60	barrier	barrier	NOUN
admet-2043	1078	61	permeability	permeability	NOUN
admet-2043	1078	62	via	via	ADP
admet-2043	1078	63	activating	activate	VERB
admet-2043	1078	64	a1	a1	NOUN
admet-2043	1078	65	adenosine	adenosine	NOUN
admet-2043	1078	66	receptor	receptor	NOUN
admet-2043	1078	67	signaling	signal	VERB
admet-2043	1078	68	pathway	pathway	NOUN
admet-2043	1078	69	.	.	PUNCT
admet-2043	1079	1	journal	journal	NOUN
admet-2043	1079	2	of	of	ADP
admet-2043	1079	3	ethnopharmacology	ethnopharmacology	NOUN
admet-2043	1079	4	246	246	NUM
admet-2043	1079	5	(	(	PUNCT
admet-2043	1079	6	2020	2020	NUM
admet-2043	1079	7	)	)	PUNCT
admet-2043	1079	8	112243	112243	NUM
admet-2043	1079	9	.	.	PUNCT
admet-2043	1080	1	https://doi.org/10.1016/j.jep.2019.112243	https://doi.org/10.1016/j.jep.2019.112243	PROPN
admet-2043	1080	2	.	.	PUNCT
admet-2043	1081	1	https://doi.org/10.3109/1061186x.2011.639022	https://doi.org/10.3109/1061186x.2011.639022	PROPN
admet-2043	1081	2	https://doi.org/10.1016/j.molmed.2012.04.012	https://doi.org/10.1016/j.molmed.2012.04.012	NOUN
admet-2043	1081	3	https://doi.org/10.1002/jps.23152	https://doi.org/10.1002/jps.23152	PROPN
admet-2043	1081	4	https://doi.org/10.1016/j.jconrel.2013.01.016	https://doi.org/10.1016/j.jconrel.2013.01.016	DET
admet-2043	1081	5	https://doi.org/10.1016/j.biomaterials.2014.02.031	https://doi.org/10.1016/j.biomaterials.2014.02.031	PROPN
admet-2043	1081	6	https://doi.org/10.1016/j.addr.2007.03.004	https://doi.org/10.1016/j.addr.2007.03.004	NOUN
admet-2043	1081	7	https://doi.org/10.1080%2f21688370.2016.1178369	https://doi.org/10.1080%2f21688370.2016.1178369	PROPN
admet-2043	1081	8	https://doi.org/10.1016/j.fct.2015.04.013	https://doi.org/10.1016/j.fct.2015.04.013	PROPN
admet-2043	1081	9	https://doi.org/10.1016/j.actbio.2015.05.009	https://doi.org/10.1016/j.actbio.2015.05.009	NUM
admet-2043	1081	10	https://doi.org/10.1007/7355_2013_22	https://doi.org/10.1007/7355_2013_22	PROPN
admet-2043	1081	11	https://doi.org/10.1080/10629360600884371	https://doi.org/10.1080/10629360600884371	PRON
admet-2043	1081	12	https://doi.org/10.1038/nrd1983	https://doi.org/10.1038/nrd1983	NOUN
admet-2043	1081	13	https://doi.org/10.1016/j.jsps.2012.05.011	https://doi.org/10.1016/j.jsps.2012.05.011	NUM
admet-2043	1081	14	https://doi.org/10.1523/jneurosci.3337-11.2011	https://doi.org/10.1523/jneurosci.3337-11.2011	PROPN
admet-2043	1081	15	https://doi.org/10.1021/nn5003375	https://doi.org/10.1021/nn5003375	PRON
admet-2043	1081	16	https://doi.org/10.1016/j.jep.2019.112243	https://doi.org/10.1016/j.jep.2019.112243	PROPN
admet-2043	1081	17	admet	admet	PROPN
admet-2043	1081	18	&	&	CCONJ
admet-2043	1081	19	dmpk	dmpk	PROPN
admet-2043	1081	20	12(1	12(1	PROPN
admet-2043	1081	21	)	)	PUNCT
admet-2043	1081	22	(	(	PUNCT
admet-2043	1081	23	2024	2024	NUM
admet-2043	1081	24	)	)	PUNCT
admet-2043	1081	25	63	63	NUM
admet-2043	1081	26	-	-	SYM
admet-2043	1081	27	105	105	NUM
admet-2043	1081	28	nanomaterials	nanomaterial	NOUN
admet-2043	1081	29	as	as	ADP
admet-2043	1081	30	drug	drug	NOUN
admet-2043	1081	31	delivery	delivery	NOUN
admet-2043	1081	32	agents	agent	NOUN
admet-2043	1081	33	for	for	ADP
admet-2043	1081	34	overcoming	overcome	VERB
admet-2043	1081	35	bbb	bbb	PROPN
admet-2043	1081	36	doi	doi	NOUN
admet-2043	1081	37	:	:	PUNCT
admet-2043	1081	38	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1081	39	97	97	NUM
admet-2043	1081	40	[	[	X
admet-2043	1081	41	81	81	NUM
admet-2043	1081	42	]	]	PUNCT
admet-2043	1081	43	z.	z.	PROPN
admet-2043	1081	44	zhao	zhao	PROPN
admet-2043	1081	45	,	,	PUNCT
admet-2043	1081	46	a.	a.	NOUN
admet-2043	1081	47	ukidve	ukidve	PROPN
admet-2043	1081	48	,	,	PUNCT
admet-2043	1081	49	j.	j.	PROPN
admet-2043	1081	50	kim	kim	PROPN
admet-2043	1081	51	,	,	PUNCT
admet-2043	1081	52	s.	s.	PROPN
admet-2043	1081	53	mitragotri	mitragotri	PROPN
admet-2043	1081	54	.	.	PUNCT
admet-2043	1082	1	targeting	target	VERB
admet-2043	1082	2	strategies	strategy	NOUN
admet-2043	1082	3	for	for	ADP
admet-2043	1082	4	tissue	tissue	NOUN
admet-2043	1082	5	-	-	PUNCT
admet-2043	1082	6	specific	specific	ADJ
admet-2043	1082	7	drug	drug	NOUN
admet-2043	1082	8	delivery	delivery	NOUN
admet-2043	1082	9	.	.	PUNCT
admet-2043	1083	1	cell	cell	NOUN
admet-2043	1083	2	181	181	NUM
admet-2043	1083	3	(	(	PUNCT
admet-2043	1083	4	2020	2020	NUM
admet-2043	1083	5	)	)	PUNCT
admet-2043	1083	6	151	151	NUM
admet-2043	1083	7	-	-	SYM
admet-2043	1083	8	167	167	NUM
admet-2043	1083	9	.	.	PUNCT
admet-2043	1083	10	https://doi.org/10.1016/j.cell.2020.02.001	https://doi.org/10.1016/j.cell.2020.02.001	NOUN
admet-2043	1083	11	.	.	PUNCT
admet-2043	1084	1	[	[	X
admet-2043	1084	2	82	82	NUM
admet-2043	1084	3	]	]	X
admet-2043	1084	4	j.	j.	PROPN
admet-2043	1084	5	park	park	PROPN
admet-2043	1084	6	,	,	PUNCT
admet-2043	1084	7	y.	y.	PROPN
admet-2043	1084	8	zhang	zhang	PROPN
admet-2043	1084	9	,	,	PUNCT
admet-2043	1084	10	n.	n.	PROPN
admet-2043	1084	11	vykhodtseva	vykhodtseva	PROPN
admet-2043	1084	12	,	,	PUNCT
admet-2043	1084	13	f.a	f.a	PROPN
admet-2043	1084	14	.	.	PROPN
admet-2043	1084	15	jolesz	jolesz	PROPN
admet-2043	1084	16	,	,	PUNCT
admet-2043	1084	17	n.j	n.j	PROPN
admet-2043	1084	18	.	.	PROPN
admet-2043	1084	19	mcdannold	mcdannold	PROPN
admet-2043	1084	20	.	.	PUNCT
admet-2043	1085	1	the	the	DET
admet-2043	1085	2	kinetics	kinetic	NOUN
admet-2043	1085	3	of	of	ADP
admet-2043	1085	4	blood	blood	NOUN
admet-2043	1085	5	brain	brain	NOUN
admet-2043	1085	6	barrier	barrier	NOUN
admet-2043	1085	7	permeability	permeability	NOUN
admet-2043	1085	8	and	and	CCONJ
admet-2043	1085	9	targeted	target	VERB
admet-2043	1085	10	doxorubicin	doxorubicin	PROPN
admet-2043	1085	11	delivery	delivery	NOUN
admet-2043	1085	12	into	into	ADP
admet-2043	1085	13	brain	brain	NOUN
admet-2043	1085	14	induced	induce	VERB
admet-2043	1085	15	by	by	ADP
admet-2043	1085	16	focused	focus	VERB
admet-2043	1085	17	ultrasound	ultrasound	PROPN
admet-2043	1085	18	.	.	PUNCT
admet-2043	1086	1	journal	journal	PROPN
admet-2043	1086	2	of	of	ADP
admet-2043	1086	3	controlled	control	VERB
admet-2043	1086	4	release	release	NOUN
admet-2043	1086	5	162	162	NUM
admet-2043	1086	6	(	(	PUNCT
admet-2043	1086	7	2012	2012	NUM
admet-2043	1086	8	)	)	PUNCT
admet-2043	1086	9	134	134	NUM
admet-2043	1086	10	-	-	SYM
admet-2043	1086	11	142	142	NUM
admet-2043	1086	12	.	.	PUNCT
admet-2043	1087	1	https://doi.org/10.1016/j.jconrel.2012.06.012	https://doi.org/10.1016/j.jconrel.2012.06.012	NOUN
admet-2043	1087	2	.	.	PUNCT
admet-2043	1088	1	[	[	X
admet-2043	1088	2	83	83	NUM
admet-2043	1088	3	]	]	PUNCT
admet-2043	1088	4	m.	m.	NOUN
admet-2043	1088	5	aryal	aryal	PROPN
admet-2043	1088	6	,	,	PUNCT
admet-2043	1088	7	k.	k.	PROPN
admet-2043	1088	8	fischer	fischer	PROPN
admet-2043	1088	9	,	,	PUNCT
admet-2043	1088	10	c.	c.	NOUN
admet-2043	1088	11	gentile	gentile	NOUN
admet-2043	1088	12	,	,	PUNCT
admet-2043	1088	13	s.	s.	PROPN
admet-2043	1088	14	gitto	gitto	PROPN
admet-2043	1088	15	,	,	PUNCT
admet-2043	1088	16	y.z	y.z	PROPN
admet-2043	1088	17	.	.	PROPN
admet-2043	1088	18	zhang	zhang	PROPN
admet-2043	1088	19	,	,	PUNCT
admet-2043	1088	20	n.	n.	PROPN
admet-2043	1088	21	mcdannold	mcdannold	PROPN
admet-2043	1088	22	.	.	PUNCT
admet-2043	1089	1	effects	effect	NOUN
admet-2043	1089	2	on	on	ADP
admet-2043	1089	3	p	p	NOUN
admet-2043	1089	4	-	-	PUNCT
admet-2043	1089	5	glycoprotein	glycoprotein	NOUN
admet-2043	1089	6	expression	expression	NOUN
admet-2043	1089	7	after	after	ADP
admet-2043	1089	8	blood	blood	NOUN
admet-2043	1089	9	-	-	PUNCT
admet-2043	1089	10	brain	brain	NOUN
admet-2043	1089	11	barrier	barrier	NOUN
admet-2043	1089	12	disruption	disruption	NOUN
admet-2043	1089	13	using	use	VERB
admet-2043	1089	14	focused	focus	VERB
admet-2043	1089	15	ultrasound	ultrasound	NOUN
admet-2043	1089	16	and	and	CCONJ
admet-2043	1089	17	microbubbles	microbubble	NOUN
admet-2043	1089	18	.	.	PUNCT
admet-2043	1090	1	plos	plos	PROPN
admet-2043	1090	2	one	one	NUM
admet-2043	1090	3	12	12	NUM
admet-2043	1090	4	(	(	PUNCT
admet-2043	1090	5	2017	2017	NUM
admet-2043	1090	6	)	)	PUNCT
admet-2043	1090	7	e0166061	e0166061	PROPN
admet-2043	1090	8	.	.	PUNCT
admet-2043	1091	1	https://doi.org/10.1371/journal.pone.0166061	https://doi.org/10.1371/journal.pone.0166061	PROPN
admet-2043	1091	2	.	.	PUNCT
admet-2043	1092	1	[	[	X
admet-2043	1092	2	84	84	NUM
admet-2043	1092	3	]	]	X
admet-2043	1092	4	h.l	h.l	PROPN
admet-2043	1092	5	.	.	PROPN
admet-2043	1092	6	liu	liu	PROPN
admet-2043	1092	7	,	,	PUNCT
admet-2043	1092	8	m.y	m.y	PROPN
admet-2043	1092	9	.	.	PROPN
admet-2043	1092	10	hua	hua	PROPN
admet-2043	1092	11	,	,	PUNCT
admet-2043	1092	12	h.w	h.w	PROPN
admet-2043	1092	13	.	.	PROPN
admet-2043	1092	14	yang	yang	PROPN
admet-2043	1092	15	,	,	PUNCT
admet-2043	1092	16	c.y	c.y	PROPN
admet-2043	1092	17	.	.	PROPN
admet-2043	1092	18	huang	huang	PROPN
admet-2043	1092	19	,	,	PUNCT
admet-2043	1092	20	p.c	p.c	PROPN
admet-2043	1092	21	.	.	PROPN
admet-2043	1092	22	chu	chu	PROPN
admet-2043	1092	23	,	,	PUNCT
admet-2043	1092	24	j.s	j.s	PROPN
admet-2043	1092	25	.	.	PROPN
admet-2043	1092	26	wu	wu	PROPN
admet-2043	1092	27	,	,	PUNCT
admet-2043	1092	28	i.c	i.c	PROPN
admet-2043	1092	29	.	.	PROPN
admet-2043	1092	30	tseng	tseng	PROPN
admet-2043	1092	31	,	,	PUNCT
admet-2043	1092	32	j.j	j.j	PROPN
admet-2043	1092	33	.	.	PROPN
admet-2043	1092	34	wang	wang	PROPN
admet-2043	1092	35	,	,	PUNCT
admet-2043	1092	36	t.c	t.c	PROPN
admet-2043	1092	37	.	.	PROPN
admet-2043	1092	38	yen	yen	PROPN
admet-2043	1092	39	,	,	PUNCT
admet-2043	1092	40	p.y	p.y	PROPN
admet-2043	1092	41	.	.	PROPN
admet-2043	1092	42	chen	chen	PROPN
admet-2043	1092	43	,	,	PUNCT
admet-2043	1092	44	k.c	k.c	PROPN
admet-2043	1092	45	.	.	PROPN
admet-2043	1092	46	wei	wei	PROPN
admet-2043	1092	47	.	.	PUNCT
admet-2043	1092	48	magnetic	magnetic	ADJ
admet-2043	1092	49	resonance	resonance	NOUN
admet-2043	1092	50	monitoring	monitoring	NOUN
admet-2043	1092	51	of	of	ADP
admet-2043	1092	52	focused	focused	ADJ
admet-2043	1092	53	ultrasound	ultrasound	PROPN
admet-2043	1092	54	/	/	SYM
admet-2043	1092	55	magnetic	magnetic	ADJ
admet-2043	1092	56	nanoparticle	nanoparticle	NOUN
admet-2043	1092	57	targeting	target	VERB
admet-2043	1092	58	delivery	delivery	NOUN
admet-2043	1092	59	of	of	ADP
admet-2043	1092	60	therapeutic	therapeutic	ADJ
admet-2043	1092	61	agents	agent	NOUN
admet-2043	1092	62	to	to	ADP
admet-2043	1092	63	the	the	DET
admet-2043	1092	64	brain	brain	NOUN
admet-2043	1092	65	.	.	PUNCT
admet-2043	1093	1	proceedings	proceeding	NOUN
admet-2043	1093	2	of	of	ADP
admet-2043	1093	3	the	the	DET
admet-2043	1093	4	national	national	PROPN
admet-2043	1093	5	academy	academy	PROPN
admet-2043	1093	6	of	of	ADP
admet-2043	1093	7	sciences	sciences	PROPN
admet-2043	1093	8	of	of	ADP
admet-2043	1093	9	the	the	DET
admet-2043	1093	10	united	united	PROPN
admet-2043	1093	11	states	states	PROPN
admet-2043	1093	12	of	of	ADP
admet-2043	1093	13	america	america	PROPN
admet-2043	1093	14	107	107	NUM
admet-2043	1093	15	(	(	PUNCT
admet-2043	1093	16	2010	2010	NUM
admet-2043	1093	17	)	)	PUNCT
admet-2043	1093	18	15205	15205	NUM
admet-2043	1093	19	-	-	SYM
admet-2043	1093	20	15210	15210	NUM
admet-2043	1093	21	.	.	PUNCT
admet-2043	1094	1	https://doi.org/10.1073/pnas.1003388107	https://doi.org/10.1073/pnas.1003388107	X
admet-2043	1094	2	.	.	PUNCT
admet-2043	1095	1	[	[	X
admet-2043	1095	2	85	85	NUM
admet-2043	1095	3	]	]	PUNCT
admet-2043	1095	4	m.	m.	NOUN
admet-2043	1095	5	aryal	aryal	PROPN
admet-2043	1095	6	,	,	PUNCT
admet-2043	1095	7	n.	n.	PROPN
admet-2043	1095	8	vykhodtseva	vykhodtseva	PROPN
admet-2043	1095	9	,	,	PUNCT
admet-2043	1095	10	y.z	y.z	PROPN
admet-2043	1095	11	.	.	PROPN
admet-2043	1095	12	zhang	zhang	PROPN
admet-2043	1095	13	,	,	PUNCT
admet-2043	1095	14	n.	n.	PROPN
admet-2043	1095	15	mcdannold	mcdannold	PROPN
admet-2043	1095	16	.	.	PUNCT
admet-2043	1096	1	multiple	multiple	ADJ
admet-2043	1096	2	sessions	session	NOUN
admet-2043	1096	3	of	of	ADP
admet-2043	1096	4	liposomal	liposomal	PROPN
admet-2043	1096	5	doxorubicin	doxorubicin	PROPN
admet-2043	1096	6	delivery	delivery	NOUN
admet-2043	1096	7	via	via	ADP
admet-2043	1096	8	focused	focus	VERB
admet-2043	1096	9	ultrasound	ultrasound	ADJ
admet-2043	1096	10	mediated	mediate	VERB
admet-2043	1096	11	blood	blood	NOUN
admet-2043	1096	12	-	-	PUNCT
admet-2043	1096	13	brain	brain	NOUN
admet-2043	1096	14	barrier	barrier	NOUN
admet-2043	1096	15	disruption	disruption	NOUN
admet-2043	1096	16	:	:	PUNCT
admet-2043	1096	17	a	a	DET
admet-2043	1096	18	safety	safety	NOUN
admet-2043	1096	19	study	study	NOUN
admet-2043	1096	20	.	.	PUNCT
admet-2043	1097	1	journal	journal	PROPN
admet-2043	1097	2	of	of	ADP
admet-2043	1097	3	controlled	control	VERB
admet-2043	1097	4	release	release	NOUN
admet-2043	1097	5	204	204	NUM
admet-2043	1097	6	(	(	PUNCT
admet-2043	1097	7	2015	2015	NUM
admet-2043	1097	8	)	)	PUNCT
admet-2043	1097	9	60	60	NUM
admet-2043	1097	10	-	-	SYM
admet-2043	1097	11	69	69	NUM
admet-2043	1097	12	.	.	PUNCT
admet-2043	1098	1	https://doi.org/10.1016/j.jconrel.2015.02.033	https://doi.org/10.1016/j.jconrel.2015.02.033	VERB
admet-2043	1098	2	.	.	PUNCT
admet-2043	1099	1	[	[	X
admet-2043	1099	2	86	86	NUM
admet-2043	1099	3	]	]	PUNCT
admet-2043	1099	4	h.	h.	PROPN
admet-2043	1099	5	chen	chen	PROPN
admet-2043	1099	6	,	,	PUNCT
admet-2043	1099	7	c.c	c.c	PROPN
admet-2043	1099	8	.	.	PROPN
admet-2043	1099	9	chen	chen	PROPN
admet-2043	1099	10	,	,	PUNCT
admet-2043	1099	11	c.	c.	PROPN
admet-2043	1099	12	acosta	acosta	PROPN
admet-2043	1099	13	,	,	PUNCT
admet-2043	1099	14	s.y	s.y	PROPN
admet-2043	1099	15	.	.	PROPN
admet-2043	1099	16	wu	wu	PROPN
admet-2043	1099	17	,	,	PUNCT
admet-2043	1099	18	t.	t.	PROPN
admet-2043	1099	19	sun	sun	PROPN
admet-2043	1099	20	,	,	PUNCT
admet-2043	1099	21	e.e	e.e	PROPN
admet-2043	1099	22	.	.	PROPN
admet-2043	1099	23	konofagou	konofagou	PROPN
admet-2043	1099	24	.	.	PUNCT
admet-2043	1100	1	a	a	DET
admet-2043	1100	2	new	new	ADJ
admet-2043	1100	3	brain	brain	NOUN
admet-2043	1100	4	drug	drug	NOUN
admet-2043	1100	5	delivery	delivery	NOUN
admet-2043	1100	6	strategy	strategy	NOUN
admet-2043	1100	7	:	:	PUNCT
admet-2043	1100	8	focused	focus	VERB
admet-2043	1100	9	ultrasound	ultrasound	NOUN
admet-2043	1100	10	-	-	PUNCT
admet-2043	1100	11	enhanced	enhance	VERB
admet-2043	1100	12	intranasal	intranasal	ADJ
admet-2043	1100	13	drug	drug	NOUN
admet-2043	1100	14	delivery	delivery	NOUN
admet-2043	1100	15	.	.	PUNCT
admet-2043	1101	1	plos	plos	PROPN
admet-2043	1101	2	one	one	NUM
admet-2043	1101	3	9	9	NUM
admet-2043	1101	4	(	(	PUNCT
admet-2043	1101	5	2014	2014	NUM
admet-2043	1101	6	)	)	PUNCT
admet-2043	1101	7	e108880	e108880	PROPN
admet-2043	1101	8	.	.	PUNCT
admet-2043	1102	1	https://doi.org/10.1371/journal.pone.0108880	https://doi.org/10.1371/journal.pone.0108880	PROPN
admet-2043	1102	2	.	.	PUNCT
admet-2043	1103	1	[	[	X
admet-2043	1103	2	87	87	NUM
admet-2043	1103	3	]	]	PUNCT
admet-2043	1103	4	y.	y.	PROPN
admet-2043	1103	5	meng	meng	PROPN
admet-2043	1103	6	,	,	PUNCT
admet-2043	1103	7	c.b	c.b	PROPN
admet-2043	1103	8	.	.	PROPN
admet-2043	1103	9	pople	pople	PROPN
admet-2043	1103	10	,	,	PUNCT
admet-2043	1103	11	h.	h.	PROPN
admet-2043	1103	12	lea	lea	PROPN
admet-2043	1103	13	-	-	PUNCT
admet-2043	1103	14	banks	bank	NOUN
admet-2043	1103	15	,	,	PUNCT
admet-2043	1103	16	a.	a.	PROPN
admet-2043	1103	17	abrahao	abrahao	PROPN
admet-2043	1103	18	,	,	PUNCT
admet-2043	1103	19	b.	b.	PROPN
admet-2043	1103	20	davidson	davidson	PROPN
admet-2043	1103	21	,	,	PUNCT
admet-2043	1103	22	s.	s.	PROPN
admet-2043	1103	23	suppiah	suppiah	PROPN
admet-2043	1103	24	,	,	PUNCT
admet-2043	1103	25	l.m	l.m	PROPN
admet-2043	1103	26	.	.	PROPN
admet-2043	1103	27	vecchio	vecchio	PROPN
admet-2043	1103	28	,	,	PUNCT
admet-2043	1103	29	n.	n.	PROPN
admet-2043	1103	30	samuel	samuel	PROPN
admet-2043	1103	31	,	,	PUNCT
admet-2043	1103	32	f.	f.	PROPN
admet-2043	1103	33	mahmud	mahmud	PROPN
admet-2043	1103	34	,	,	PUNCT
admet-2043	1103	35	k.	k.	PROPN
admet-2043	1103	36	hynynen	hynynen	PROPN
admet-2043	1103	37	,	,	PUNCT
admet-2043	1103	38	c.	c.	PROPN
admet-2043	1103	39	hamani	hamani	PROPN
admet-2043	1103	40	,	,	PUNCT
admet-2043	1103	41	n.	n.	PROPN
admet-2043	1103	42	lipsman	lipsman	PROPN
admet-2043	1103	43	.	.	PUNCT
admet-2043	1103	44	safety	safety	NOUN
admet-2043	1103	45	and	and	CCONJ
admet-2043	1103	46	efficacy	efficacy	NOUN
admet-2043	1103	47	of	of	ADP
admet-2043	1103	48	focused	focused	ADJ
admet-2043	1103	49	ultrasound	ultrasound	ADJ
admet-2043	1103	50	induced	induced	ADJ
admet-2043	1103	51	blood	blood	NOUN
admet-2043	1103	52	-	-	PUNCT
admet-2043	1103	53	brain	brain	NOUN
admet-2043	1103	54	barrier	barrier	NOUN
admet-2043	1103	55	opening	opening	NOUN
admet-2043	1103	56	,	,	PUNCT
admet-2043	1103	57	an	an	DET
admet-2043	1103	58	integrative	integrative	ADJ
admet-2043	1103	59	review	review	NOUN
admet-2043	1103	60	of	of	ADP
admet-2043	1103	61	animal	animal	NOUN
admet-2043	1103	62	and	and	CCONJ
admet-2043	1103	63	human	human	ADJ
admet-2043	1103	64	studies	study	NOUN
admet-2043	1103	65	.	.	PUNCT
admet-2043	1104	1	journal	journal	PROPN
admet-2043	1104	2	of	of	ADP
admet-2043	1104	3	controlled	control	VERB
admet-2043	1104	4	release	release	NOUN
admet-2043	1104	5	309	309	NUM
admet-2043	1104	6	(	(	PUNCT
admet-2043	1104	7	2019	2019	NUM
admet-2043	1104	8	)	)	PUNCT
admet-2043	1104	9	25	25	NUM
admet-2043	1104	10	-	-	SYM
admet-2043	1104	11	36	36	NUM
admet-2043	1104	12	.	.	PUNCT
admet-2043	1105	1	https://doi.org/10.1016/j.jconrel.2019.07.023	https://doi.org/10.1016/j.jconrel.2019.07.023	NOUN
admet-2043	1105	2	.	.	PUNCT
admet-2043	1106	1	[	[	X
admet-2043	1106	2	88	88	NUM
admet-2043	1106	3	]	]	X
admet-2043	1106	4	q.z	q.z	PROPN
admet-2043	1106	5	.	.	PROPN
admet-2043	1106	6	zhang	zhang	PROPN
admet-2043	1106	7	,	,	PUNCT
admet-2043	1106	8	l.s	l.s	PROPN
admet-2043	1106	9	.	.	PROPN
admet-2043	1106	10	zha	zha	PROPN
admet-2043	1106	11	,	,	PUNCT
admet-2043	1106	12	y.	y.	PROPN
admet-2043	1106	13	zhang	zhang	PROPN
admet-2043	1106	14	,	,	PUNCT
admet-2043	1106	15	w.m	w.m	PROPN
admet-2043	1106	16	.	.	PROPN
admet-2043	1106	17	jiang	jiang	PROPN
admet-2043	1106	18	,	,	PUNCT
admet-2043	1106	19	w.	w.	PROPN
admet-2043	1106	20	lu	lu	PROPN
admet-2043	1106	21	,	,	PUNCT
admet-2043	1106	22	z.q	z.q	PROPN
admet-2043	1106	23	.	.	PROPN
admet-2043	1106	24	shi	shi	PROPN
admet-2043	1106	25	,	,	PUNCT
admet-2043	1106	26	x.g	x.g	PROPN
admet-2043	1106	27	.	.	PROPN
admet-2043	1106	28	jiang	jiang	PROPN
admet-2043	1106	29	,	,	PUNCT
admet-2043	1106	30	s.k	s.k	PROPN
admet-2043	1106	31	.	.	PROPN
admet-2043	1106	32	fu	fu	PROPN
admet-2043	1106	33	.	.	PUNCT
admet-2043	1107	1	the	the	DET
admet-2043	1107	2	brain	brain	NOUN
admet-2043	1107	3	targeting	target	VERB
admet-2043	1107	4	efficiency	efficiency	NOUN
admet-2043	1107	5	following	follow	VERB
admet-2043	1107	6	nasally	nasally	ADV
admet-2043	1107	7	applied	apply	VERB
admet-2043	1107	8	mpeg	mpeg	NOUN
admet-2043	1107	9	-	-	PUNCT
admet-2043	1107	10	pla	pla	NOUN
admet-2043	1107	11	nanoparticles	nanoparticle	NOUN
admet-2043	1107	12	in	in	ADP
admet-2043	1107	13	rats	rat	NOUN
admet-2043	1107	14	.	.	PUNCT
admet-2043	1108	1	journal	journal	NOUN
admet-2043	1108	2	of	of	ADP
admet-2043	1108	3	drug	drug	NOUN
admet-2043	1108	4	targeting	target	VERB
admet-2043	1108	5	14	14	NUM
admet-2043	1108	6	(	(	PUNCT
admet-2043	1108	7	2006	2006	NUM
admet-2043	1108	8	)	)	PUNCT
admet-2043	1108	9	281	281	NUM
admet-2043	1108	10	-	-	SYM
admet-2043	1108	11	290	290	NUM
admet-2043	1108	12	.	.	PUNCT
admet-2043	1109	1	https://doi.org/10.1080/10611860600721051	https://doi.org/10.1080/10611860600721051	VERB
admet-2043	1109	2	.	.	PUNCT
admet-2043	1110	1	[	[	X
admet-2043	1110	2	89	89	NUM
admet-2043	1110	3	]	]	PUNCT
admet-2043	1110	4	x.	x.	NOUN
admet-2043	1110	5	zheng	zheng	PROPN
admet-2043	1110	6	,	,	PUNCT
admet-2043	1110	7	c.	c.	PROPN
admet-2043	1110	8	zhang	zhang	PROPN
admet-2043	1110	9	,	,	PUNCT
admet-2043	1110	10	q.	q.	PROPN
admet-2043	1110	11	guo	guo	PROPN
admet-2043	1110	12	,	,	PUNCT
admet-2043	1110	13	x.	x.	PROPN
admet-2043	1110	14	wan	wan	PROPN
admet-2043	1110	15	,	,	PUNCT
admet-2043	1110	16	x.	x.	PROPN
admet-2043	1110	17	shao	shao	PROPN
admet-2043	1110	18	,	,	PUNCT
admet-2043	1110	19	q.	q.	PROPN
admet-2043	1110	20	liu	liu	PROPN
admet-2043	1110	21	,	,	PUNCT
admet-2043	1110	22	q.	q.	PROPN
admet-2043	1110	23	zhang	zhang	PROPN
admet-2043	1110	24	.	.	PUNCT
admet-2043	1111	1	dual	dual	ADJ
admet-2043	1111	2	-	-	PUNCT
admet-2043	1111	3	functional	functional	ADJ
admet-2043	1111	4	nanoparticles	nanoparticle	NOUN
admet-2043	1111	5	for	for	ADP
admet-2043	1111	6	precise	precise	ADJ
admet-2043	1111	7	drug	drug	NOUN
admet-2043	1111	8	delivery	delivery	NOUN
admet-2043	1111	9	to	to	ADP
admet-2043	1111	10	alzheimer	alzheimer	PROPN
admet-2043	1111	11	's	's	PART
admet-2043	1111	12	disease	disease	NOUN
admet-2043	1111	13	lesions	lesion	NOUN
admet-2043	1111	14	:	:	PUNCT
admet-2043	1111	15	targeting	target	VERB
admet-2043	1111	16	mechanisms	mechanism	NOUN
admet-2043	1111	17	,	,	PUNCT
admet-2043	1111	18	pharmacodynamics	pharmacodynamic	NOUN
admet-2043	1111	19	and	and	CCONJ
admet-2043	1111	20	safety	safety	NOUN
admet-2043	1111	21	.	.	PUNCT
admet-2043	1112	1	international	international	ADJ
admet-2043	1112	2	journal	journal	PROPN
admet-2043	1112	3	of	of	ADP
admet-2043	1112	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	1112	5	525	525	NUM
admet-2043	1112	6	(	(	PUNCT
admet-2043	1112	7	2017	2017	NUM
admet-2043	1112	8	)	)	PUNCT
admet-2043	1112	9	237	237	NUM
admet-2043	1112	10	-	-	SYM
admet-2043	1112	11	248	248	NUM
admet-2043	1112	12	.	.	PUNCT
admet-2043	1113	1	https://doi.org/10.1016/j.ijpharm.2017.04.033	https://doi.org/10.1016/j.ijpharm.2017.04.033	NOUN
admet-2043	1113	2	.	.	PUNCT
admet-2043	1114	1	[	[	X
admet-2043	1114	2	90	90	NUM
admet-2043	1114	3	]	]	PUNCT
admet-2043	1114	4	q.	q.	PROPN
admet-2043	1114	5	zhang	zhang	PROPN
admet-2043	1114	6	,	,	PUNCT
admet-2043	1114	7	x.	x.	PROPN
admet-2043	1114	8	jiang	jiang	PROPN
admet-2043	1114	9	,	,	PUNCT
admet-2043	1114	10	w.	w.	PROPN
admet-2043	1114	11	jiang	jiang	PROPN
admet-2043	1114	12	,	,	PUNCT
admet-2043	1114	13	w.	w.	PROPN
admet-2043	1114	14	lu	lu	PROPN
admet-2043	1114	15	,	,	PUNCT
admet-2043	1114	16	l.	l.	PROPN
admet-2043	1114	17	su	su	PROPN
admet-2043	1114	18	,	,	PUNCT
admet-2043	1114	19	z.	z.	PROPN
admet-2043	1114	20	shi	shi	PROPN
admet-2043	1114	21	.	.	PUNCT
admet-2043	1115	1	preparation	preparation	NOUN
admet-2043	1115	2	of	of	ADP
admet-2043	1115	3	nimodipine	nimodipine	NOUN
admet-2043	1115	4	-	-	PUNCT
admet-2043	1115	5	loaded	load	VERB
admet-2043	1115	6	microemulsion	microemulsion	NOUN
admet-2043	1115	7	for	for	ADP
admet-2043	1115	8	intranasal	intranasal	ADJ
admet-2043	1115	9	delivery	delivery	NOUN
admet-2043	1115	10	and	and	CCONJ
admet-2043	1115	11	evaluation	evaluation	NOUN
admet-2043	1115	12	on	on	ADP
admet-2043	1115	13	the	the	DET
admet-2043	1115	14	targeting	target	VERB
admet-2043	1115	15	efficiency	efficiency	NOUN
admet-2043	1115	16	to	to	ADP
admet-2043	1115	17	the	the	DET
admet-2043	1115	18	brain	brain	NOUN
admet-2043	1115	19	.	.	PUNCT
admet-2043	1116	1	international	international	ADJ
admet-2043	1116	2	journal	journal	PROPN
admet-2043	1116	3	of	of	ADP
admet-2043	1116	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	1116	5	275	275	NUM
admet-2043	1116	6	(	(	PUNCT
admet-2043	1116	7	2004	2004	NUM
admet-2043	1116	8	)	)	PUNCT
admet-2043	1116	9	85	85	NUM
admet-2043	1116	10	-	-	SYM
admet-2043	1116	11	96	96	NUM
admet-2043	1116	12	.	.	PUNCT
admet-2043	1117	1	https://doi.org/10.1016/j.ijpharm.2004.01.039	https://doi.org/10.1016/j.ijpharm.2004.01.039	NOUN
admet-2043	1117	2	.	.	PUNCT
admet-2043	1118	1	[	[	X
admet-2043	1118	2	91	91	NUM
admet-2043	1118	3	]	]	PUNCT
admet-2043	1118	4	x.	x.	NOUN
admet-2043	1118	5	zheng	zheng	PROPN
admet-2043	1118	6	,	,	PUNCT
admet-2043	1118	7	x.	x.	PROPN
admet-2043	1118	8	shao	shao	PROPN
admet-2043	1118	9	,	,	PUNCT
admet-2043	1118	10	c.	c.	PROPN
admet-2043	1118	11	zhang	zhang	PROPN
admet-2043	1118	12	,	,	PUNCT
admet-2043	1118	13	y.	y.	PROPN
admet-2043	1118	14	tan	tan	PROPN
admet-2043	1118	15	,	,	PUNCT
admet-2043	1118	16	q.	q.	PROPN
admet-2043	1118	17	liu	liu	PROPN
admet-2043	1118	18	,	,	PUNCT
admet-2043	1118	19	x.	x.	PROPN
admet-2043	1118	20	wan	wan	PROPN
admet-2043	1118	21	,	,	PUNCT
admet-2043	1118	22	q.	q.	PROPN
admet-2043	1118	23	zhang	zhang	PROPN
admet-2043	1118	24	,	,	PUNCT
admet-2043	1118	25	s.	s.	PROPN
admet-2043	1118	26	xu	xu	PROPN
admet-2043	1118	27	,	,	PUNCT
admet-2043	1118	28	x.	x.	PROPN
admet-2043	1118	29	jiang	jiang	PROPN
admet-2043	1118	30	.	.	PUNCT
admet-2043	1119	1	intranasal	intranasal	VERB
admet-2043	1119	2	h102	h102	PROPN
admet-2043	1119	3	peptide	peptide	NOUN
admet-2043	1119	4	-	-	PUNCT
admet-2043	1119	5	loaded	load	VERB
admet-2043	1119	6	liposomes	liposome	NOUN
admet-2043	1119	7	for	for	ADP
admet-2043	1119	8	brain	brain	NOUN
admet-2043	1119	9	delivery	delivery	NOUN
admet-2043	1119	10	to	to	PART
admet-2043	1119	11	treat	treat	VERB
admet-2043	1119	12	alzheimer	alzheimer	PROPN
admet-2043	1119	13	's	's	PART
admet-2043	1119	14	disease	disease	NOUN
admet-2043	1119	15	.	.	PUNCT
admet-2043	1120	1	pharmaceutical	pharmaceutical	ADJ
admet-2043	1120	2	research	research	NOUN
admet-2043	1120	3	32	32	NUM
admet-2043	1120	4	(	(	PUNCT
admet-2043	1120	5	2015	2015	NUM
admet-2043	1120	6	)	)	PUNCT
admet-2043	1120	7	3837	3837	NUM
admet-2043	1120	8	-	-	SYM
admet-2043	1120	9	3849	3849	NUM
admet-2043	1120	10	.	.	PUNCT
admet-2043	1121	1	https://doi.org/10.1007/s11095-015-1744-9	https://doi.org/10.1007/s11095-015-1744-9	NUM
admet-2043	1121	2	.	.	PUNCT
admet-2043	1122	1	[	[	X
admet-2043	1122	2	92	92	NUM
admet-2043	1122	3	]	]	X
admet-2043	1122	4	y.	y.	PROPN
admet-2043	1122	5	zorkina	zorkina	PROPN
admet-2043	1122	6	,	,	PUNCT
admet-2043	1122	7	o.	o.	PROPN
admet-2043	1122	8	abramova	abramova	PROPN
admet-2043	1122	9	,	,	PUNCT
admet-2043	1122	10	v.	v.	PROPN
admet-2043	1122	11	ushakova	ushakova	PROPN
admet-2043	1122	12	,	,	PUNCT
admet-2043	1122	13	a.	a.	NOUN
admet-2043	1122	14	morozova	morozova	PROPN
admet-2043	1122	15	,	,	PUNCT
admet-2043	1122	16	e.	e.	PROPN
admet-2043	1122	17	zubkov	zubkov	PROPN
admet-2043	1122	18	,	,	PUNCT
admet-2043	1122	19	m.	m.	NOUN
admet-2043	1122	20	valikhov	valikhov	PROPN
admet-2043	1122	21	,	,	PUNCT
admet-2043	1122	22	p.	p.	NOUN
admet-2043	1122	23	melnikov	melnikov	PROPN
admet-2043	1122	24	,	,	PUNCT
admet-2043	1122	25	a.	a.	NOUN
admet-2043	1122	26	majouga	majouga	PROPN
admet-2043	1122	27	,	,	PUNCT
admet-2043	1122	28	v.	v.	PROPN
admet-2043	1122	29	chekhonin	chekhonin	PROPN
admet-2043	1122	30	.	.	PUNCT
admet-2043	1123	1	nano	nano	NOUN
admet-2043	1123	2	carrier	carrier	NOUN
admet-2043	1123	3	drug	drug	NOUN
admet-2043	1123	4	delivery	delivery	NOUN
admet-2043	1123	5	systems	system	NOUN
admet-2043	1123	6	for	for	ADP
admet-2043	1123	7	the	the	DET
admet-2043	1123	8	treatment	treatment	NOUN
admet-2043	1123	9	of	of	ADP
admet-2043	1123	10	neuropsychiatric	neuropsychiatric	ADJ
admet-2043	1123	11	disorders	disorder	NOUN
admet-2043	1123	12	:	:	PUNCT
admet-2043	1123	13	advantages	advantage	NOUN
admet-2043	1123	14	and	and	CCONJ
admet-2043	1123	15	limitations	limitation	NOUN
admet-2043	1123	16	.	.	PUNCT
admet-2043	1124	1	molecules	molecule	NOUN
admet-2043	1124	2	25	25	NUM
admet-2043	1124	3	(	(	PUNCT
admet-2043	1124	4	2020	2020	NUM
admet-2043	1124	5	)	)	PUNCT
admet-2043	1124	6	5294	5294	NUM
admet-2043	1124	7	.	.	PUNCT
admet-2043	1125	1	https://doi.org/10.3390/molecules25225294	https://doi.org/10.3390/molecules25225294	NOUN
admet-2043	1125	2	.	.	PUNCT
admet-2043	1126	1	[	[	X
admet-2043	1126	2	93	93	NUM
admet-2043	1126	3	]	]	PUNCT
admet-2043	1126	4	f.	f.	PROPN
admet-2043	1126	5	tameire	tameire	PROPN
admet-2043	1126	6	,	,	PUNCT
admet-2043	1126	7	verginadis	verginadi	NOUN
admet-2043	1126	8	,	,	PUNCT
admet-2043	1126	9	ii	ii	PROPN
admet-2043	1126	10	,	,	PUNCT
admet-2043	1126	11	c.	c.	PROPN
admet-2043	1126	12	koumenis	koumenis	PROPN
admet-2043	1126	13	.	.	PUNCT
admet-2043	1127	1	cell	cell	NOUN
admet-2043	1127	2	intrinsic	intrinsic	ADJ
admet-2043	1127	3	and	and	CCONJ
admet-2043	1127	4	extrinsic	extrinsic	ADJ
admet-2043	1127	5	activators	activator	NOUN
admet-2043	1127	6	of	of	ADP
admet-2043	1127	7	the	the	DET
admet-2043	1127	8	unfolded	unfolded	ADJ
admet-2043	1127	9	protein	protein	NOUN
admet-2043	1127	10	response	response	NOUN
admet-2043	1127	11	in	in	ADP
admet-2043	1127	12	cancer	cancer	NOUN
admet-2043	1127	13	:	:	PUNCT
admet-2043	1127	14	mechanisms	mechanism	NOUN
admet-2043	1127	15	and	and	CCONJ
admet-2043	1127	16	targets	target	NOUN
admet-2043	1127	17	for	for	ADP
admet-2043	1127	18	therapy	therapy	NOUN
admet-2043	1127	19	.	.	PUNCT
admet-2043	1128	1	seminars	seminar	NOUN
admet-2043	1128	2	in	in	ADP
admet-2043	1128	3	cancer	cancer	NOUN
admet-2043	1128	4	biology	biology	NOUN
admet-2043	1128	5	33	33	NUM
admet-2043	1128	6	(	(	PUNCT
admet-2043	1128	7	2015	2015	NUM
admet-2043	1128	8	)	)	PUNCT
admet-2043	1128	9	3	3	NUM
admet-2043	1128	10	-	-	SYM
admet-2043	1128	11	15	15	NUM
admet-2043	1128	12	.	.	PUNCT
admet-2043	1129	1	https://doi.org/10.1016/j.semcancer.2015.04.002	https://doi.org/10.1016/j.semcancer.2015.04.002	NUM
admet-2043	1129	2	.	.	PUNCT
admet-2043	1130	1	[	[	X
admet-2043	1130	2	94	94	NUM
admet-2043	1130	3	]	]	X
admet-2043	1130	4	a.o	a.o	PROPN
admet-2043	1130	5	.	.	PROPN
admet-2043	1130	6	elzoghby	elzoghby	PROPN
admet-2043	1130	7	,	,	PUNCT
admet-2043	1130	8	m.m	m.m	PROPN
admet-2043	1130	9	.	.	PROPN
admet-2043	1130	10	abd	abd	PROPN
admet-2043	1130	11	-	-	PUNCT
admet-2043	1130	12	elwakil	elwakil	PROPN
admet-2043	1130	13	,	,	PUNCT
admet-2043	1130	14	k.	k.	PROPN
admet-2043	1130	15	abd	abd	PROPN
admet-2043	1130	16	-	-	PUNCT
admet-2043	1130	17	elsalam	elsalam	PROPN
admet-2043	1130	18	,	,	PUNCT
admet-2043	1130	19	m.t	m.t	PROPN
admet-2043	1130	20	.	.	PROPN
admet-2043	1130	21	elsayed	elsaye	VERB
admet-2043	1130	22	,	,	PUNCT
admet-2043	1130	23	y.	y.	PROPN
admet-2043	1130	24	hashem	hashem	PROPN
admet-2043	1130	25	,	,	PUNCT
admet-2043	1130	26	o.	o.	PROPN
admet-2043	1130	27	mohamed	mohamed	PROPN
admet-2043	1130	28	.	.	PUNCT
admet-2043	1131	1	natural	natural	ADJ
admet-2043	1131	2	polymeric	polymeric	ADJ
admet-2043	1131	3	nanoparticles	nanoparticle	NOUN
admet-2043	1131	4	for	for	ADP
admet-2043	1131	5	brain	brain	NOUN
admet-2043	1131	6	-	-	PUNCT
admet-2043	1131	7	targeting	targeting	NOUN
admet-2043	1131	8	:	:	PUNCT
admet-2043	1131	9	implications	implication	NOUN
admet-2043	1131	10	on	on	ADP
admet-2043	1131	11	drug	drug	NOUN
admet-2043	1131	12	and	and	CCONJ
admet-2043	1131	13	gene	gene	NOUN
admet-2043	1131	14	delivery	delivery	NOUN
admet-2043	1131	15	.	.	PUNCT
admet-2043	1132	1	current	current	ADJ
admet-2043	1132	2	pharmaceutical	pharmaceutical	ADJ
admet-2043	1132	3	design	design	NOUN
admet-2043	1132	4	22	22	NUM
admet-2043	1132	5	(	(	PUNCT
admet-2043	1132	6	2016	2016	NUM
admet-2043	1132	7	)	)	PUNCT
admet-2043	1132	8	3305	3305	NUM
admet-2043	1132	9	-	-	SYM
admet-2043	1132	10	3323	3323	NUM
admet-2043	1132	11	.	.	PUNCT
admet-2043	1133	1	https://doi.org/10.2174/1381612822666160204120829	https://doi.org/10.2174/1381612822666160204120829	NOUN
admet-2043	1133	2	.	.	PUNCT
admet-2043	1134	1	[	[	X
admet-2043	1134	2	95	95	NUM
admet-2043	1134	3	]	]	X
admet-2043	1134	4	h.	h.	PROPN
admet-2043	1134	5	wu	wu	PROPN
admet-2043	1134	6	,	,	PUNCT
admet-2043	1134	7	k.	k.	PROPN
admet-2043	1134	8	hu	hu	PROPN
admet-2043	1134	9	,	,	PUNCT
admet-2043	1134	10	x.	x.	PROPN
admet-2043	1134	11	jiang	jiang	PROPN
admet-2043	1134	12	.	.	PUNCT
admet-2043	1135	1	from	from	ADP
admet-2043	1135	2	nose	nose	NOUN
admet-2043	1135	3	to	to	ADP
admet-2043	1135	4	brain	brain	NOUN
admet-2043	1135	5	:	:	PUNCT
admet-2043	1135	6	understanding	understand	VERB
admet-2043	1135	7	transport	transport	NOUN
admet-2043	1135	8	capacity	capacity	NOUN
admet-2043	1135	9	and	and	CCONJ
admet-2043	1135	10	transport	transport	NOUN
admet-2043	1135	11	rate	rate	NOUN
admet-2043	1135	12	of	of	ADP
admet-2043	1135	13	drugs	drug	NOUN
admet-2043	1135	14	.	.	PUNCT
admet-2043	1136	1	expert	expert	ADJ
admet-2043	1136	2	opinion	opinion	NOUN
admet-2043	1136	3	on	on	ADP
admet-2043	1136	4	drug	drug	NOUN
admet-2043	1136	5	delivery	delivery	NOUN
admet-2043	1136	6	5	5	NUM
admet-2043	1136	7	(	(	PUNCT
admet-2043	1136	8	2008	2008	NUM
admet-2043	1136	9	)	)	PUNCT
admet-2043	1136	10	1159	1159	NUM
admet-2043	1136	11	-	-	SYM
admet-2043	1136	12	1168	1168	NUM
admet-2043	1136	13	.	.	PUNCT
admet-2043	1137	1	https://doi.org/10.1517/17425247.5.10.1159	https://doi.org/10.1517/17425247.5.10.1159	NOUN
admet-2043	1137	2	.	.	PUNCT
admet-2043	1138	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1138	2	https://doi.org/10.1016/j.cell.2020.02.001	https://doi.org/10.1016/j.cell.2020.02.001	NOUN
admet-2043	1138	3	https://doi.org/10.1016/j.jconrel.2012.06.012	https://doi.org/10.1016/j.jconrel.2012.06.012	PRON
admet-2043	1138	4	https://doi.org/10.1371/journal.pone.0166061	https://doi.org/10.1371/journal.pone.0166061	VERB
admet-2043	1138	5	https://doi.org/10.1073/pnas.1003388107	https://doi.org/10.1073/pnas.1003388107	NOUN
admet-2043	1139	1	https://doi.org/10.1016/j.jconrel.2015.02.033	https://doi.org/10.1016/j.jconrel.2015.02.033	VERB
admet-2043	1139	2	https://doi.org/10.1371/journal.pone.0108880	https://doi.org/10.1371/journal.pone.0108880	PROPN
admet-2043	1139	3	https://doi.org/10.1016/j.jconrel.2019.07.023	https://doi.org/10.1016/j.jconrel.2019.07.023	NOUN
admet-2043	1139	4	https://doi.org/10.1080/10611860600721051	https://doi.org/10.1080/10611860600721051	VERB
admet-2043	1139	5	https://doi.org/10.1016/j.ijpharm.2017.04.033	https://doi.org/10.1016/j.ijpharm.2017.04.033	PROPN
admet-2043	1139	6	https://doi.org/10.1016/j.ijpharm.2004.01.039	https://doi.org/10.1016/j.ijpharm.2004.01.039	NOUN
admet-2043	1139	7	https://doi.org/10.1007/s11095-015-1744-9	https://doi.org/10.1007/s11095-015-1744-9	NUM
admet-2043	1139	8	https://doi.org/10.3390/molecules25225294	https://doi.org/10.3390/molecules25225294	NOUN
admet-2043	1139	9	https://doi.org/10.1016/j.semcancer.2015.04.002	https://doi.org/10.1016/j.semcancer.2015.04.002	NOUN
admet-2043	1139	10	https://doi.org/10.2174/1381612822666160204120829	https://doi.org/10.2174/1381612822666160204120829	NUM
admet-2043	1139	11	https://doi.org/10.1517/17425247.5.10.1159	https://doi.org/10.1517/17425247.5.10.1159	PROPN
admet-2043	1139	12	m.	m.	NOUN
admet-2043	1139	13	kulkarni	kulkarni	PROPN
admet-2043	1139	14	et	et	PROPN
admet-2043	1139	15	al	al	PROPN
admet-2043	1139	16	.	.	PROPN
admet-2043	1139	17	admet	admet	PROPN
admet-2043	1139	18	&	&	CCONJ
admet-2043	1139	19	dmpk	dmpk	PROPN
admet-2043	1139	20	12(1	12(1	PROPN
admet-2043	1139	21	)	)	PUNCT
admet-2043	1139	22	(	(	PUNCT
admet-2043	1139	23	2024	2024	NUM
admet-2043	1139	24	)	)	PUNCT
admet-2043	1139	25	63	63	NUM
admet-2043	1139	26	-	-	SYM
admet-2043	1139	27	105	105	NUM
admet-2043	1139	28	98	98	NUM
admet-2043	1140	1	[	[	X
admet-2043	1140	2	96	96	NUM
admet-2043	1140	3	]	]	PUNCT
admet-2043	1140	4	x.	x.	NOUN
admet-2043	1140	5	gao	gao	PROPN
admet-2043	1140	6	,	,	PUNCT
admet-2043	1140	7	b.	b.	PROPN
admet-2043	1140	8	wu	wu	PROPN
admet-2043	1140	9	,	,	PUNCT
admet-2043	1140	10	q.	q.	PROPN
admet-2043	1140	11	zhang	zhang	PROPN
admet-2043	1140	12	,	,	PUNCT
admet-2043	1140	13	j.	j.	PROPN
admet-2043	1140	14	chen	chen	PROPN
admet-2043	1140	15	,	,	PUNCT
admet-2043	1140	16	j.	j.	PROPN
admet-2043	1140	17	zhu	zhu	PROPN
admet-2043	1140	18	,	,	PUNCT
admet-2043	1140	19	w.	w.	PROPN
admet-2043	1140	20	zhang	zhang	PROPN
admet-2043	1140	21	,	,	PUNCT
admet-2043	1140	22	z.	z.	PROPN
admet-2043	1140	23	rong	rong	PROPN
admet-2043	1140	24	,	,	PUNCT
admet-2043	1140	25	h.	h.	PROPN
admet-2043	1140	26	chen	chen	PROPN
admet-2043	1140	27	,	,	PUNCT
admet-2043	1140	28	x.	x.	PROPN
admet-2043	1140	29	jiang	jiang	PROPN
admet-2043	1140	30	.	.	PUNCT
admet-2043	1141	1	brain	brain	NOUN
admet-2043	1141	2	delivery	delivery	NOUN
admet-2043	1141	3	of	of	ADP
admet-2043	1141	4	vasoactive	vasoactive	ADJ
admet-2043	1141	5	intestinal	intestinal	ADJ
admet-2043	1141	6	peptide	peptide	NOUN
admet-2043	1141	7	enhanced	enhance	VERB
admet-2043	1141	8	with	with	ADP
admet-2043	1141	9	the	the	DET
admet-2043	1141	10	nanoparticles	nanoparticle	NOUN
admet-2043	1141	11	conjugated	conjugate	VERB
admet-2043	1141	12	with	with	ADP
admet-2043	1141	13	wheat	wheat	NOUN
admet-2043	1141	14	germ	germ	NOUN
admet-2043	1141	15	agglutinin	agglutinin	NOUN
admet-2043	1141	16	following	follow	VERB
admet-2043	1141	17	intranasal	intranasal	ADJ
admet-2043	1141	18	administration	administration	NOUN
admet-2043	1141	19	.	.	PUNCT
admet-2043	1142	1	journal	journal	PROPN
admet-2043	1142	2	of	of	ADP
admet-2043	1142	3	controlled	control	VERB
admet-2043	1142	4	release	release	NOUN
admet-2043	1142	5	121	121	NUM
admet-2043	1142	6	(	(	PUNCT
admet-2043	1142	7	2007	2007	NUM
admet-2043	1142	8	)	)	PUNCT
admet-2043	1142	9	156	156	NUM
admet-2043	1142	10	-	-	SYM
admet-2043	1142	11	167	167	NUM
admet-2043	1142	12	.	.	PUNCT
admet-2043	1143	1	https://doi.org/10.1016/j.jconrel.2007.05.026	https://doi.org/10.1016/j.jconrel.2007.05.026	PROPN
admet-2043	1143	2	.	.	PUNCT
admet-2043	1144	1	[	[	X
admet-2043	1144	2	97	97	NUM
admet-2043	1144	3	]	]	PUNCT
admet-2043	1144	4	q.	q.	PROPN
admet-2043	1144	5	liu	liu	PROPN
admet-2043	1144	6	,	,	PUNCT
admet-2043	1144	7	y.	y.	PROPN
admet-2043	1144	8	shen	shen	PROPN
admet-2043	1144	9	,	,	PUNCT
admet-2043	1144	10	j.	j.	PROPN
admet-2043	1144	11	chen	chen	PROPN
admet-2043	1144	12	,	,	PUNCT
admet-2043	1144	13	x.	x.	PROPN
admet-2043	1144	14	gao	gao	PROPN
admet-2043	1144	15	,	,	PUNCT
admet-2043	1144	16	c.	c.	PROPN
admet-2043	1144	17	feng	feng	PROPN
admet-2043	1144	18	,	,	PUNCT
admet-2043	1144	19	l.	l.	PROPN
admet-2043	1144	20	wang	wang	PROPN
admet-2043	1144	21	,	,	PUNCT
admet-2043	1144	22	q.	q.	PROPN
admet-2043	1144	23	zhang	zhang	PROPN
admet-2043	1144	24	,	,	PUNCT
admet-2043	1144	25	x.	x.	PROPN
admet-2043	1144	26	jiang	jiang	PROPN
admet-2043	1144	27	.	.	PUNCT
admet-2043	1145	1	nose	nose	PROPN
admet-2043	1145	2	-	-	PUNCT
admet-2043	1145	3	to	to	ADP
admet-2043	1145	4	-	-	PUNCT
admet-2043	1145	5	brain	brain	NOUN
admet-2043	1145	6	transport	transport	NOUN
admet-2043	1145	7	pathways	pathway	NOUN
admet-2043	1145	8	of	of	ADP
admet-2043	1145	9	wheat	wheat	NOUN
admet-2043	1145	10	germ	germ	NOUN
admet-2043	1145	11	agglutinin	agglutinin	NOUN
admet-2043	1145	12	conjugated	conjugate	VERB
admet-2043	1145	13	peg	peg	NOUN
admet-2043	1145	14	-	-	PUNCT
admet-2043	1145	15	pla	pla	NOUN
admet-2043	1145	16	nanoparticles	nanoparticle	NOUN
admet-2043	1145	17	.	.	PUNCT
admet-2043	1146	1	pharmaceutical	pharmaceutical	ADJ
admet-2043	1146	2	research	research	NOUN
admet-2043	1146	3	29	29	NUM
admet-2043	1146	4	(	(	PUNCT
admet-2043	1146	5	2012	2012	NUM
admet-2043	1146	6	)	)	PUNCT
admet-2043	1146	7	546	546	NUM
admet-2043	1146	8	-	-	SYM
admet-2043	1146	9	558	558	NUM
admet-2043	1146	10	.	.	PUNCT
admet-2043	1147	1	https://doi.org/10.1007/s11095-011-0641-0	https://doi.org/10.1007/s11095-011-0641-0	NUM
admet-2043	1147	2	.	.	PUNCT
admet-2043	1148	1	[	[	X
admet-2043	1148	2	98	98	NUM
admet-2043	1148	3	]	]	PUNCT
admet-2043	1148	4	z.	z.	PROPN
admet-2043	1148	5	wen	wen	PROPN
admet-2043	1148	6	,	,	PUNCT
admet-2043	1148	7	z.	z.	PROPN
admet-2043	1148	8	yan	yan	PROPN
admet-2043	1148	9	,	,	PUNCT
admet-2043	1148	10	k.	k.	PROPN
admet-2043	1148	11	hu	hu	PROPN
admet-2043	1148	12	,	,	PUNCT
admet-2043	1148	13	z.	z.	PROPN
admet-2043	1148	14	pang	pang	PROPN
admet-2043	1148	15	,	,	PUNCT
admet-2043	1148	16	x.	x.	PROPN
admet-2043	1148	17	cheng	cheng	PROPN
admet-2043	1148	18	,	,	PUNCT
admet-2043	1148	19	l.	l.	PROPN
admet-2043	1148	20	guo	guo	PROPN
admet-2043	1148	21	,	,	PUNCT
admet-2043	1148	22	q.	q.	PROPN
admet-2043	1148	23	zhang	zhang	PROPN
admet-2043	1148	24	,	,	PUNCT
admet-2043	1148	25	x.	x.	PROPN
admet-2043	1148	26	jiang	jiang	PROPN
admet-2043	1148	27	,	,	PUNCT
admet-2043	1148	28	l.	l.	PROPN
admet-2043	1148	29	fang	fang	PROPN
admet-2043	1148	30	,	,	PUNCT
admet-2043	1148	31	r.	r.	PROPN
admet-2043	1148	32	lai	lai	PROPN
admet-2043	1148	33	.	.	PUNCT
admet-2043	1149	1	odorranalectinconjugated	odorranalectinconjugate	VERB
admet-2043	1149	2	nanoparticles	nanoparticle	NOUN
admet-2043	1149	3	:	:	PUNCT
admet-2043	1149	4	preparation	preparation	NOUN
admet-2043	1149	5	,	,	PUNCT
admet-2043	1149	6	brain	brain	NOUN
admet-2043	1149	7	delivery	delivery	NOUN
admet-2043	1149	8	and	and	CCONJ
admet-2043	1149	9	pharmacodynamic	pharmacodynamic	ADJ
admet-2043	1149	10	study	study	NOUN
admet-2043	1149	11	on	on	ADP
admet-2043	1149	12	parkinson	parkinson	NOUN
admet-2043	1149	13	's	's	PART
admet-2043	1149	14	disease	disease	NOUN
admet-2043	1149	15	following	follow	VERB
admet-2043	1149	16	intranasal	intranasal	ADJ
admet-2043	1149	17	administration	administration	NOUN
admet-2043	1149	18	.	.	PUNCT
admet-2043	1150	1	journal	journal	PROPN
admet-2043	1150	2	of	of	ADP
admet-2043	1150	3	controlled	control	VERB
admet-2043	1150	4	release	release	NOUN
admet-2043	1150	5	151	151	NUM
admet-2043	1150	6	(	(	PUNCT
admet-2043	1150	7	2011	2011	NUM
admet-2043	1150	8	)	)	PUNCT
admet-2043	1150	9	131	131	NUM
admet-2043	1150	10	-	-	SYM
admet-2043	1150	11	138	138	NUM
admet-2043	1150	12	.	.	PUNCT
admet-2043	1151	1	https://doi.org/10.1016/j.jconrel.2011.02.022	https://doi.org/10.1016/j.jconrel.2011.02.022	NOUN
admet-2043	1151	2	.	.	PUNCT
admet-2043	1152	1	[	[	X
admet-2043	1152	2	99	99	NUM
admet-2043	1152	3	]	]	X
admet-2043	1152	4	h.	h.	PROPN
admet-2043	1152	5	wu	wu	PROPN
admet-2043	1152	6	,	,	PUNCT
admet-2043	1152	7	j.	j.	PROPN
admet-2043	1152	8	li	li	PROPN
admet-2043	1152	9	,	,	PUNCT
admet-2043	1152	10	q.	q.	PROPN
admet-2043	1152	11	zhang	zhang	PROPN
admet-2043	1152	12	,	,	PUNCT
admet-2043	1152	13	x.	x.	PROPN
admet-2043	1152	14	yan	yan	PROPN
admet-2043	1152	15	,	,	PUNCT
admet-2043	1152	16	l.	l.	PROPN
admet-2043	1152	17	guo	guo	PROPN
admet-2043	1152	18	,	,	PUNCT
admet-2043	1152	19	x.	x.	PROPN
admet-2043	1152	20	gao	gao	PROPN
admet-2043	1152	21	,	,	PUNCT
admet-2043	1152	22	m.	m.	NOUN
admet-2043	1152	23	qiu	qiu	PROPN
admet-2043	1152	24	,	,	PUNCT
admet-2043	1152	25	x.	x.	PROPN
admet-2043	1152	26	jiang	jiang	PROPN
admet-2043	1152	27	,	,	PUNCT
admet-2043	1152	28	r.	r.	PROPN
admet-2043	1152	29	lai	lai	PROPN
admet-2043	1152	30	,	,	PUNCT
admet-2043	1152	31	h.	h.	PROPN
admet-2043	1152	32	chen	chen	PROPN
admet-2043	1152	33	.	.	PUNCT
admet-2043	1153	1	a	a	DET
admet-2043	1153	2	novel	novel	ADJ
admet-2043	1153	3	small	small	ADJ
admet-2043	1153	4	odorranalectin	odorranalectin	NOUN
admet-2043	1153	5	-	-	PUNCT
admet-2043	1153	6	bearing	bear	VERB
admet-2043	1153	7	cubosomes	cubosome	NOUN
admet-2043	1153	8	:	:	PUNCT
admet-2043	1153	9	preparation	preparation	NOUN
admet-2043	1153	10	,	,	PUNCT
admet-2043	1153	11	brain	brain	NOUN
admet-2043	1153	12	delivery	delivery	NOUN
admet-2043	1153	13	and	and	CCONJ
admet-2043	1153	14	pharmacodynamic	pharmacodynamic	ADJ
admet-2043	1153	15	study	study	NOUN
admet-2043	1153	16	on	on	ADP
admet-2043	1153	17	amyloid	amyloid	NOUN
admet-2043	1153	18	-	-	PUNCT
admet-2043	1153	19	beta(2)(5)(-)(3)(5)-treated	beta(2)(5)(-)(3)(5)-treate	VERB
admet-2043	1153	20	rats	rat	NOUN
admet-2043	1153	21	following	follow	VERB
admet-2043	1153	22	intranasal	intranasal	ADJ
admet-2043	1153	23	administration	administration	NOUN
admet-2043	1153	24	.	.	PUNCT
admet-2043	1154	1	european	european	PROPN
admet-2043	1154	2	journal	journal	PROPN
admet-2043	1154	3	of	of	ADP
admet-2043	1154	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	1154	5	and	and	CCONJ
admet-2043	1154	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2043	1154	7	80	80	NUM
admet-2043	1154	8	(	(	PUNCT
admet-2043	1154	9	2012	2012	NUM
admet-2043	1154	10	)	)	PUNCT
admet-2043	1154	11	368	368	NUM
admet-2043	1154	12	-	-	SYM
admet-2043	1154	13	378	378	NUM
admet-2043	1154	14	.	.	PUNCT
admet-2043	1155	1	https://doi.org/10.1016/j.ejpb.2011.10.012	https://doi.org/10.1016/j.ejpb.2011.10.012	NOUN
admet-2043	1155	2	.	.	PUNCT
admet-2043	1156	1	[	[	X
admet-2043	1156	2	100	100	NUM
admet-2043	1156	3	]	]	PUNCT
admet-2043	1156	4	s.	s.	PROPN
admet-2043	1156	5	jha	jha	PROPN
admet-2043	1156	6	,	,	PUNCT
admet-2043	1156	7	d.	d.	PROPN
admet-2043	1156	8	mishra	mishra	PROPN
admet-2043	1156	9	.	.	PROPN
admet-2043	1156	10	evaluation	evaluation	NOUN
admet-2043	1156	11	of	of	ADP
admet-2043	1156	12	brain	brain	NOUN
admet-2043	1156	13	targeting	target	VERB
admet-2043	1156	14	potential	potential	NOUN
admet-2043	1156	15	of	of	ADP
admet-2043	1156	16	zolmitriptan	zolmitriptan	PROPN
admet-2043	1156	17	mucoadhesive	mucoadhesive	ADJ
admet-2043	1156	18	nanoparticles	nanoparticle	NOUN
admet-2043	1156	19	for	for	ADP
admet-2043	1156	20	intranasal	intranasal	ADJ
admet-2043	1156	21	drug	drug	NOUN
admet-2043	1156	22	delivery	delivery	NOUN
admet-2043	1156	23	.	.	PUNCT
admet-2043	1157	1	pharmaceutical	pharmaceutical	PROPN
admet-2043	1157	2	nanotechnology	nanotechnology	PROPN
admet-2043	1157	3	10	10	NUM
admet-2043	1157	4	(	(	PUNCT
admet-2043	1157	5	2022	2022	NUM
admet-2043	1157	6	)	)	PUNCT
admet-2043	1157	7	113	113	NUM
admet-2043	1157	8	-	-	SYM
admet-2043	1157	9	124	124	NUM
admet-2043	1157	10	.	.	PUNCT
admet-2043	1158	1	https://doi.org/10.2174/2211738510666220303160414	https://doi.org/10.2174/2211738510666220303160414	X
admet-2043	1158	2	.	.	PUNCT
admet-2043	1159	1	[	[	X
admet-2043	1159	2	101	101	X
admet-2043	1159	3	]	]	PUNCT
admet-2043	1159	4	v.	v.	X
admet-2043	1159	5	soni	soni	PROPN
admet-2043	1159	6	,	,	PUNCT
admet-2043	1159	7	v.	v.	PROPN
admet-2043	1159	8	pandey	pandey	PROPN
admet-2043	1159	9	,	,	PUNCT
admet-2043	1159	10	s.	s.	PROPN
admet-2043	1159	11	asati	asati	PROPN
admet-2043	1159	12	,	,	PUNCT
admet-2043	1159	13	p.	p.	PROPN
admet-2043	1159	14	jain	jain	PROPN
admet-2043	1159	15	,	,	PUNCT
admet-2043	1159	16	r.k	r.k	PROPN
admet-2043	1159	17	.	.	PROPN
admet-2043	1159	18	tekade	tekade	PROPN
admet-2043	1159	19	,	,	PUNCT
admet-2043	1159	20	design	design	NOUN
admet-2043	1159	21	and	and	CCONJ
admet-2043	1159	22	fabrication	fabrication	NOUN
admet-2043	1159	23	of	of	ADP
admet-2043	1159	24	brain	brain	NOUN
admet-2043	1159	25	-	-	PUNCT
admet-2043	1159	26	targeted	target	VERB
admet-2043	1159	27	drug	drug	NOUN
admet-2043	1159	28	delivery	delivery	NOUN
admet-2043	1159	29	,	,	PUNCT
admet-2043	1159	30	in	in	ADP
admet-2043	1159	31	basic	basic	ADJ
admet-2043	1159	32	fundamentals	fundamental	NOUN
admet-2043	1159	33	of	of	ADP
admet-2043	1159	34	drug	drug	NOUN
admet-2043	1159	35	delivery	delivery	NOUN
admet-2043	1159	36	,	,	PUNCT
admet-2043	1159	37	elsevier2019	elsevier2019	PROPN
admet-2043	1159	38	,	,	PUNCT
admet-2043	1159	39	p.	p.	NOUN
admet-2043	1159	40	539	539	NUM
admet-2043	1159	41	-	-	SYM
admet-2043	1159	42	593	593	NUM
admet-2043	1159	43	9780128179093	9780128179093	NUM
admet-2043	1159	44	.	.	PUNCT
admet-2043	1160	1	https://doi.org/10.1016/b978-0-12-817909-3.00014-5	https://doi.org/10.1016/b978-0-12-817909-3.00014-5	NOUN
admet-2043	1160	2	.	.	PUNCT
admet-2043	1161	1	[	[	X
admet-2043	1161	2	102	102	NUM
admet-2043	1161	3	]	]	PUNCT
admet-2043	1161	4	a.m.	a.m.	NOUN
admet-2043	1161	5	hersh	hersh	PROPN
admet-2043	1161	6	,	,	PUNCT
admet-2043	1161	7	s.	s.	PROPN
admet-2043	1161	8	alomari	alomari	PROPN
admet-2043	1161	9	,	,	PUNCT
admet-2043	1161	10	b.m	b.m	PROPN
admet-2043	1161	11	.	.	PROPN
admet-2043	1161	12	tyler	tyler	PROPN
admet-2043	1161	13	.	.	PUNCT
admet-2043	1162	1	crossing	cross	VERB
admet-2043	1162	2	the	the	DET
admet-2043	1162	3	blood	blood	NOUN
admet-2043	1162	4	-	-	PUNCT
admet-2043	1162	5	brain	brain	NOUN
admet-2043	1162	6	barrier	barrier	NOUN
admet-2043	1162	7	:	:	PUNCT
admet-2043	1162	8	advances	advance	NOUN
admet-2043	1162	9	in	in	ADP
admet-2043	1162	10	nanoparticle	nanoparticle	NOUN
admet-2043	1162	11	technology	technology	NOUN
admet-2043	1162	12	for	for	ADP
admet-2043	1162	13	drug	drug	NOUN
admet-2043	1162	14	delivery	delivery	NOUN
admet-2043	1162	15	in	in	ADP
admet-2043	1162	16	neuro	neuro	NOUN
admet-2043	1162	17	-	-	PUNCT
admet-2043	1162	18	oncology	oncology	NOUN
admet-2043	1162	19	.	.	PUNCT
admet-2043	1163	1	international	international	ADJ
admet-2043	1163	2	journal	journal	NOUN
admet-2043	1163	3	of	of	ADP
admet-2043	1163	4	molecular	molecular	ADJ
admet-2043	1163	5	sciences	science	NOUN
admet-2043	1163	6	23	23	NUM
admet-2043	1163	7	(	(	PUNCT
admet-2043	1163	8	2022	2022	NUM
admet-2043	1163	9	)	)	PUNCT
admet-2043	1163	10	4153	4153	NUM
admet-2043	1163	11	.	.	PUNCT
admet-2043	1164	1	[	[	X
admet-2043	1164	2	103	103	NUM
admet-2043	1164	3	]	]	X
admet-2043	1164	4	r.	r.	PROPN
admet-2043	1164	5	barbara	barbara	PROPN
admet-2043	1164	6	,	,	PUNCT
admet-2043	1164	7	d.	d.	PROPN
admet-2043	1164	8	belletti	belletti	PROPN
admet-2043	1164	9	,	,	PUNCT
admet-2043	1164	10	f.	f.	PROPN
admet-2043	1164	11	pederzoli	pederzoli	PROPN
admet-2043	1164	12	,	,	PUNCT
admet-2043	1164	13	m.	m.	NOUN
admet-2043	1164	14	masoni	masoni	PROPN
admet-2043	1164	15	,	,	PUNCT
admet-2043	1164	16	j.	j.	PROPN
admet-2043	1164	17	keller	keller	PROPN
admet-2043	1164	18	,	,	PUNCT
admet-2043	1164	19	a.	a.	PROPN
admet-2043	1164	20	ballestrazzi	ballestrazzi	PROPN
admet-2043	1164	21	,	,	PUNCT
admet-2043	1164	22	m.a	m.a	PROPN
admet-2043	1164	23	.	.	PROPN
admet-2043	1164	24	vandelli	vandelli	PROPN
admet-2043	1164	25	,	,	PUNCT
admet-2043	1164	26	g.	g.	PROPN
admet-2043	1164	27	tosi	tosi	PROPN
admet-2043	1164	28	,	,	PUNCT
admet-2043	1164	29	a.m.	a.m.	PROPN
admet-2043	1164	30	grabrucker	grabrucker	NOUN
admet-2043	1164	31	.	.	PUNCT
admet-2043	1165	1	novel	novel	NOUN
admet-2043	1165	2	curcumin	curcumin	NOUN
admet-2043	1165	3	loaded	load	VERB
admet-2043	1165	4	nanoparticles	nanoparticle	NOUN
admet-2043	1165	5	engineered	engineer	VERB
admet-2043	1165	6	for	for	ADP
admet-2043	1165	7	blood	blood	NOUN
admet-2043	1165	8	-	-	PUNCT
admet-2043	1165	9	brain	brain	NOUN
admet-2043	1165	10	barrier	barrier	NOUN
admet-2043	1165	11	crossing	crossing	NOUN
admet-2043	1165	12	and	and	CCONJ
admet-2043	1165	13	able	able	ADJ
admet-2043	1165	14	to	to	PART
admet-2043	1165	15	disrupt	disrupt	VERB
admet-2043	1165	16	abeta	abeta	NOUN
admet-2043	1165	17	aggregates	aggregate	NOUN
admet-2043	1165	18	.	.	PUNCT
admet-2043	1166	1	international	international	ADJ
admet-2043	1166	2	journal	journal	PROPN
admet-2043	1166	3	of	of	ADP
admet-2043	1166	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	1166	5	526	526	NUM
admet-2043	1166	6	(	(	PUNCT
admet-2043	1166	7	2017	2017	NUM
admet-2043	1166	8	)	)	PUNCT
admet-2043	1166	9	413	413	NUM
admet-2043	1166	10	-	-	SYM
admet-2043	1166	11	424	424	NUM
admet-2043	1166	12	.	.	PUNCT
admet-2043	1167	1	https://doi.org/10.1016/j.ijpharm.2017.05.015	https://doi.org/10.1016/j.ijpharm.2017.05.015	X
admet-2043	1167	2	.	.	PUNCT
admet-2043	1168	1	[	[	X
admet-2043	1168	2	104	104	X
admet-2043	1168	3	]	]	X
admet-2043	1168	4	y.	y.	PROPN
admet-2043	1168	5	shen	shen	PROPN
admet-2043	1168	6	,	,	PUNCT
admet-2043	1168	7	b.	b.	PROPN
admet-2043	1168	8	cao	cao	PROPN
admet-2043	1168	9	,	,	PUNCT
admet-2043	1168	10	n.r	n.r	PROPN
admet-2043	1168	11	.	.	PROPN
admet-2043	1168	12	snyder	snyder	PROPN
admet-2043	1168	13	,	,	PUNCT
admet-2043	1168	14	k.m	k.m	PROPN
admet-2043	1168	15	.	.	PROPN
admet-2043	1168	16	woeppel	woeppel	PROPN
admet-2043	1168	17	,	,	PUNCT
admet-2043	1168	18	j.r	j.r	PROPN
admet-2043	1168	19	.	.	PROPN
admet-2043	1168	20	eles	eles	PROPN
admet-2043	1168	21	,	,	PUNCT
admet-2043	1168	22	x.t	x.t	PROPN
admet-2043	1168	23	.	.	PROPN
admet-2043	1168	24	cui	cui	PROPN
admet-2043	1168	25	.	.	PUNCT
admet-2043	1169	1	ros	ros	PROPN
admet-2043	1169	2	responsive	responsive	ADJ
admet-2043	1169	3	resveratrol	resveratrol	NOUN
admet-2043	1169	4	delivery	delivery	NOUN
admet-2043	1169	5	from	from	ADP
admet-2043	1169	6	ldlr	ldlr	ADJ
admet-2043	1169	7	peptide	peptide	NOUN
admet-2043	1169	8	conjugated	conjugate	VERB
admet-2043	1169	9	pla	pla	NOUN
admet-2043	1169	10	-	-	PUNCT
admet-2043	1169	11	coated	coat	VERB
admet-2043	1169	12	mesoporous	mesoporous	ADJ
admet-2043	1169	13	silica	silica	NOUN
admet-2043	1169	14	nanoparticles	nanoparticle	NOUN
admet-2043	1169	15	across	across	ADP
admet-2043	1169	16	the	the	DET
admet-2043	1169	17	blood	blood	NOUN
admet-2043	1169	18	-	-	PUNCT
admet-2043	1169	19	brain	brain	NOUN
admet-2043	1169	20	barrier	barrier	NOUN
admet-2043	1169	21	.	.	PUNCT
admet-2043	1170	1	journal	journal	NOUN
admet-2043	1170	2	of	of	ADP
admet-2043	1170	3	nanobiotechnology	nanobiotechnology	NOUN
admet-2043	1170	4	16	16	NUM
admet-2043	1170	5	(	(	PUNCT
admet-2043	1170	6	2018	2018	NUM
admet-2043	1170	7	)	)	PUNCT
admet-2043	1170	8	13	13	NUM
admet-2043	1170	9	.	.	PUNCT
admet-2043	1171	1	https://doi.org/10.1186/s12951-018-0340-7	https://doi.org/10.1186/s12951-018-0340-7	NUM
admet-2043	1171	2	.	.	PUNCT
admet-2043	1172	1	[	[	X
admet-2043	1172	2	105	105	NUM
admet-2043	1172	3	]	]	X
admet-2043	1172	4	j.	j.	PROPN
admet-2043	1172	5	ahlawat	ahlawat	PROPN
admet-2043	1172	6	,	,	PUNCT
admet-2043	1172	7	g.	g.	PROPN
admet-2043	1172	8	guillama	guillama	PROPN
admet-2043	1172	9	barroso	barroso	PROPN
admet-2043	1172	10	,	,	PUNCT
admet-2043	1172	11	s.	s.	PROPN
admet-2043	1172	12	masoudi	masoudi	ADJ
admet-2043	1172	13	asil	asil	PROPN
admet-2043	1172	14	,	,	PUNCT
admet-2043	1172	15	m.	m.	NOUN
admet-2043	1172	16	alvarado	alvarado	PROPN
admet-2043	1172	17	,	,	PUNCT
admet-2043	1172	18	i.	i.	PROPN
admet-2043	1172	19	armendariz	armendariz	PROPN
admet-2043	1172	20	,	,	PUNCT
admet-2043	1172	21	j.	j.	PROPN
admet-2043	1172	22	bernal	bernal	PROPN
admet-2043	1172	23	,	,	PUNCT
admet-2043	1172	24	x.	x.	NOUN
admet-2043	1172	25	carabaza	carabaza	PROPN
admet-2043	1172	26	,	,	PUNCT
admet-2043	1172	27	s.	s.	PROPN
admet-2043	1172	28	chavez	chavez	PROPN
admet-2043	1172	29	,	,	PUNCT
admet-2043	1172	30	p.	p.	NOUN
admet-2043	1172	31	cruz	cruz	PROPN
admet-2043	1172	32	,	,	PUNCT
admet-2043	1172	33	v.	v.	PROPN
admet-2043	1172	34	escalante	escalante	PROPN
admet-2043	1172	35	,	,	PUNCT
admet-2043	1172	36	s.	s.	PROPN
admet-2043	1172	37	estorga	estorga	PROPN
admet-2043	1172	38	,	,	PUNCT
admet-2043	1172	39	d.	d.	PROPN
admet-2043	1172	40	fernandez	fernandez	PROPN
admet-2043	1172	41	,	,	PUNCT
admet-2043	1172	42	c.	c.	PROPN
admet-2043	1172	43	lozano	lozano	PROPN
admet-2043	1172	44	,	,	PUNCT
admet-2043	1172	45	m.	m.	PROPN
admet-2043	1172	46	marrufo	marrufo	PROPN
admet-2043	1172	47	,	,	PUNCT
admet-2043	1172	48	n.	n.	PROPN
admet-2043	1172	49	ahmad	ahmad	PROPN
admet-2043	1172	50	,	,	PUNCT
admet-2043	1172	51	s.	s.	PROPN
admet-2043	1172	52	negrete	negrete	PROPN
admet-2043	1172	53	,	,	PUNCT
admet-2043	1172	54	k.	k.	PROPN
admet-2043	1172	55	olvera	olvera	PROPN
admet-2043	1172	56	,	,	PUNCT
admet-2043	1172	57	x.	x.	PROPN
admet-2043	1172	58	parada	parada	PROPN
admet-2043	1172	59	,	,	PUNCT
admet-2043	1172	60	b.	b.	PROPN
admet-2043	1172	61	portillo	portillo	PROPN
admet-2043	1172	62	,	,	PUNCT
admet-2043	1172	63	a.	a.	PROPN
admet-2043	1172	64	ramirez	ramirez	PROPN
admet-2043	1172	65	,	,	PUNCT
admet-2043	1172	66	r.	r.	PROPN
admet-2043	1172	67	ramos	ramos	PROPN
admet-2043	1172	68	,	,	PUNCT
admet-2043	1172	69	v.	v.	PROPN
admet-2043	1172	70	rodriguez	rodriguez	PROPN
admet-2043	1172	71	,	,	PUNCT
admet-2043	1172	72	p.	p.	PROPN
admet-2043	1172	73	rojas	rojas	PROPN
admet-2043	1172	74	,	,	PUNCT
admet-2043	1172	75	j.	j.	PROPN
admet-2043	1172	76	romero	romero	PROPN
admet-2043	1172	77	,	,	PUNCT
admet-2043	1172	78	d.	d.	PROPN
admet-2043	1172	79	suarez	suarez	PROPN
admet-2043	1172	80	,	,	PUNCT
admet-2043	1172	81	g.	g.	PROPN
admet-2043	1172	82	urueta	urueta	PROPN
admet-2043	1172	83	,	,	PUNCT
admet-2043	1172	84	s.	s.	PROPN
admet-2043	1172	85	viel	viel	PROPN
admet-2043	1172	86	,	,	PUNCT
admet-2043	1172	87	m.	m.	NOUN
admet-2043	1172	88	narayan	narayan	PROPN
admet-2043	1172	89	.	.	PUNCT
admet-2043	1173	1	nanocarriers	nanocarrier	NOUN
admet-2043	1173	2	as	as	ADP
admet-2043	1173	3	potential	potential	ADJ
admet-2043	1173	4	drug	drug	NOUN
admet-2043	1173	5	delivery	delivery	NOUN
admet-2043	1173	6	candidates	candidate	NOUN
admet-2043	1173	7	for	for	ADP
admet-2043	1173	8	overcoming	overcome	VERB
admet-2043	1173	9	the	the	DET
admet-2043	1173	10	blood	blood	NOUN
admet-2043	1173	11	-	-	PUNCT
admet-2043	1173	12	brain	brain	NOUN
admet-2043	1173	13	barrier	barrier	NOUN
admet-2043	1173	14	:	:	PUNCT
admet-2043	1173	15	challenges	challenge	NOUN
admet-2043	1173	16	and	and	CCONJ
admet-2043	1173	17	possibilities	possibility	NOUN
admet-2043	1173	18	.	.	PUNCT
admet-2043	1174	1	acs	acs	PROPN
admet-2043	1174	2	omega	omega	NOUN
admet-2043	1174	3	5	5	NUM
admet-2043	1174	4	(	(	PUNCT
admet-2043	1174	5	2020	2020	NUM
admet-2043	1174	6	)	)	PUNCT
admet-2043	1174	7	12583	12583	NUM
admet-2043	1174	8	-	-	SYM
admet-2043	1174	9	12595	12595	NUM
admet-2043	1174	10	.	.	PUNCT
admet-2043	1175	1	https://doi.org/10.1021/acsomega.0c01592	https://doi.org/10.1021/acsomega.0c01592	NOUN
admet-2043	1175	2	.	.	PUNCT
admet-2043	1176	1	[	[	X
admet-2043	1176	2	106	106	X
admet-2043	1176	3	]	]	X
admet-2043	1176	4	j.	j.	PROPN
admet-2043	1176	5	wolfram	wolfram	PROPN
admet-2043	1176	6	,	,	PUNCT
admet-2043	1176	7	m.	m.	PROPN
admet-2043	1176	8	zhu	zhu	PROPN
admet-2043	1176	9	,	,	PUNCT
admet-2043	1176	10	y.	y.	PROPN
admet-2043	1176	11	yang	yang	PROPN
admet-2043	1176	12	,	,	PUNCT
admet-2043	1176	13	j.	j.	PROPN
admet-2043	1176	14	shen	shen	PROPN
admet-2043	1176	15	,	,	PUNCT
admet-2043	1176	16	e.	e.	PROPN
admet-2043	1176	17	gentile	gentile	PROPN
admet-2043	1176	18	,	,	PUNCT
admet-2043	1176	19	d.	d.	PROPN
admet-2043	1176	20	paolino	paolino	PROPN
admet-2043	1176	21	,	,	PUNCT
admet-2043	1176	22	m.	m.	NOUN
admet-2043	1176	23	fresta	fresta	PROPN
admet-2043	1176	24	,	,	PUNCT
admet-2043	1176	25	g.	g.	PROPN
admet-2043	1176	26	nie	nie	PROPN
admet-2043	1176	27	,	,	PUNCT
admet-2043	1176	28	c.	c.	PROPN
admet-2043	1176	29	chen	chen	PROPN
admet-2043	1176	30	,	,	PUNCT
admet-2043	1176	31	h.	h.	PROPN
admet-2043	1176	32	shen	shen	PROPN
admet-2043	1176	33	,	,	PUNCT
admet-2043	1176	34	m.	m.	NOUN
admet-2043	1176	35	ferrari	ferrari	PROPN
admet-2043	1176	36	,	,	PUNCT
admet-2043	1176	37	y.	y.	PROPN
admet-2043	1176	38	zhao	zhao	PROPN
admet-2043	1176	39	.	.	PUNCT
admet-2043	1177	1	safety	safety	NOUN
admet-2043	1177	2	of	of	ADP
admet-2043	1177	3	nanoparticles	nanoparticle	NOUN
admet-2043	1177	4	in	in	ADP
admet-2043	1177	5	medicine	medicine	NOUN
admet-2043	1177	6	.	.	PUNCT
admet-2043	1178	1	current	current	ADJ
admet-2043	1178	2	drug	drug	NOUN
admet-2043	1178	3	targets	target	NOUN
admet-2043	1178	4	16	16	NUM
admet-2043	1178	5	(	(	PUNCT
admet-2043	1178	6	2015	2015	NUM
admet-2043	1178	7	)	)	PUNCT
admet-2043	1178	8	1671	1671	NUM
admet-2043	1178	9	-	-	SYM
admet-2043	1178	10	1681	1681	NUM
admet-2043	1178	11	.	.	PUNCT
admet-2043	1179	1	https://doi.org/10.2174/1389450115666140804124808	https://doi.org/10.2174/1389450115666140804124808	NOUN
admet-2043	1179	2	.	.	PUNCT
admet-2043	1180	1	[	[	X
admet-2043	1180	2	107	107	NUM
admet-2043	1180	3	]	]	X
admet-2043	1180	4	w.m	w.m	PROPN
admet-2043	1180	5	.	.	PROPN
admet-2043	1180	6	pardridge	pardridge	NOUN
admet-2043	1180	7	.	.	PUNCT
admet-2043	1181	1	blood	blood	NOUN
admet-2043	1181	2	-	-	PUNCT
admet-2043	1181	3	brain	brain	NOUN
admet-2043	1181	4	barrier	barrier	NOUN
admet-2043	1181	5	and	and	CCONJ
admet-2043	1181	6	delivery	delivery	NOUN
admet-2043	1181	7	of	of	ADP
admet-2043	1181	8	protein	protein	NOUN
admet-2043	1181	9	and	and	CCONJ
admet-2043	1181	10	gene	gene	NOUN
admet-2043	1181	11	therapeutics	therapeutic	NOUN
admet-2043	1181	12	to	to	AUX
admet-2043	1181	13	brain	brain	VERB
admet-2043	1181	14	.	.	PUNCT
admet-2043	1182	1	frontiers	frontier	NOUN
admet-2043	1182	2	in	in	ADP
admet-2043	1182	3	aging	age	VERB
admet-2043	1182	4	neuroscience	neuroscience	NOUN
admet-2043	1182	5	11	11	NUM
admet-2043	1182	6	(	(	PUNCT
admet-2043	1182	7	2019	2019	NUM
admet-2043	1182	8	)	)	PUNCT
admet-2043	1182	9	373	373	NUM
admet-2043	1182	10	.	.	PUNCT
admet-2043	1183	1	https://doi.org/10.3389/fnagi.2019.00373	https://doi.org/10.3389/fnagi.2019.00373	PROPN
admet-2043	1183	2	.	.	PUNCT
admet-2043	1184	1	[	[	X
admet-2043	1184	2	108	108	NUM
admet-2043	1184	3	]	]	PUNCT
admet-2043	1184	4	s.	s.	PROPN
admet-2043	1184	5	lahkar	lahkar	PROPN
admet-2043	1184	6	,	,	PUNCT
admet-2043	1184	7	m.k	m.k	PROPN
admet-2043	1184	8	.	.	PUNCT
admet-2043	1184	9	das	das	PROPN
admet-2043	1184	10	.	.	PROPN
admet-2043	1184	11	surface	surface	NOUN
admet-2043	1184	12	-	-	PUNCT
admet-2043	1184	13	modified	modify	VERB
admet-2043	1184	14	polycaprolactone	polycaprolactone	NOUN
admet-2043	1184	15	nanoparticles	nanoparticle	NOUN
admet-2043	1184	16	for	for	ADP
admet-2043	1184	17	the	the	DET
admet-2043	1184	18	brain	brain	NOUN
admet-2043	1184	19	-	-	PUNCT
admet-2043	1184	20	targeted	target	VERB
admet-2043	1184	21	delivery	delivery	NOUN
admet-2043	1184	22	of	of	ADP
admet-2043	1184	23	nevirapine	nevirapine	ADJ
admet-2043	1184	24	.	.	PUNCT
admet-2043	1185	1	journal	journal	PROPN
admet-2043	1185	2	of	of	ADP
admet-2043	1185	3	nanoparticle	nanoparticle	PROPN
admet-2043	1185	4	research	research	NOUN
admet-2043	1185	5	22	22	NUM
admet-2043	1185	6	(	(	PUNCT
admet-2043	1185	7	2020	2020	NUM
admet-2043	1185	8	)	)	PUNCT
admet-2043	1185	9	109	109	NUM
admet-2043	1185	10	.	.	PUNCT
admet-2043	1185	11	https://doi.org/10.1007/s11051-020-04831-9	https://doi.org/10.1007/s11051-020-04831-9	NUM
admet-2043	1185	12	.	.	PUNCT
admet-2043	1186	1	[	[	X
admet-2043	1186	2	109	109	NUM
admet-2043	1186	3	]	]	PUNCT
admet-2043	1186	4	a.	a.	NOUN
admet-2043	1186	5	unnisa	unnisa	NOUN
admet-2043	1186	6	,	,	PUNCT
admet-2043	1186	7	n.h	n.h	PROPN
admet-2043	1186	8	.	.	PUNCT
admet-2043	1186	9	greig	greig	PROPN
admet-2043	1186	10	,	,	PUNCT
admet-2043	1186	11	m.a	m.a	PROPN
admet-2043	1186	12	.	.	PROPN
admet-2043	1186	13	kamal	kamal	PROPN
admet-2043	1186	14	.	.	PUNCT
admet-2043	1187	1	nanotechnology	nanotechnology	NOUN
admet-2043	1187	2	-	-	PUNCT
admet-2043	1187	3	based	base	VERB
admet-2043	1187	4	gene	gene	NOUN
admet-2043	1187	5	therapy	therapy	NOUN
admet-2043	1187	6	as	as	ADP
admet-2043	1187	7	a	a	DET
admet-2043	1187	8	credible	credible	ADJ
admet-2043	1187	9	tool	tool	NOUN
admet-2043	1187	10	in	in	ADP
admet-2043	1187	11	the	the	DET
admet-2043	1187	12	treatment	treatment	NOUN
admet-2043	1187	13	of	of	ADP
admet-2043	1187	14	alzheimer	alzheimer	PROPN
admet-2043	1187	15	's	's	PART
admet-2043	1187	16	disease	disease	NOUN
admet-2043	1187	17	.	.	PUNCT
admet-2043	1188	1	neural	neural	ADJ
admet-2043	1188	2	regeneration	regeneration	NOUN
admet-2043	1188	3	research	research	NOUN
admet-2043	1188	4	18	18	NUM
admet-2043	1188	5	(	(	PUNCT
admet-2043	1188	6	2023	2023	NUM
admet-2043	1188	7	)	)	PUNCT
admet-2043	1188	8	2127	2127	NUM
admet-2043	1188	9	-	-	SYM
admet-2043	1188	10	2133	2133	NUM
admet-2043	1188	11	.	.	PUNCT
admet-2043	1189	1	https://doi.org/10.4103/1673-5374.369096	https://doi.org/10.4103/1673-5374.369096	NOUN
admet-2043	1189	2	.	.	PUNCT
admet-2043	1190	1	[	[	X
admet-2043	1190	2	110	110	NUM
admet-2043	1190	3	]	]	PUNCT
admet-2043	1190	4	t.	t.	PROPN
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admet-2043	1190	7	b.	b.	PROPN
admet-2043	1190	8	fogarty	fogarty	PROPN
admet-2043	1190	9	,	,	PUNCT
admet-2043	1190	10	b.	b.	PROPN
admet-2043	1190	11	laforge	laforge	PROPN
admet-2043	1190	12	,	,	PUNCT
admet-2043	1190	13	s.	s.	PROPN
admet-2043	1190	14	aziz	aziz	PROPN
admet-2043	1190	15	,	,	PUNCT
admet-2043	1190	16	t.	t.	PROPN
admet-2043	1190	17	pham	pham	PROPN
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admet-2043	1190	19	l.	l.	PROPN
admet-2043	1190	20	lai	lai	PROPN
admet-2043	1190	21	,	,	PUNCT
admet-2043	1190	22	s.	s.	PROPN
admet-2043	1190	23	bai	bai	PROPN
admet-2043	1190	24	.	.	PUNCT
admet-2043	1191	1	delivery	delivery	NOUN
admet-2043	1191	2	of	of	ADP
admet-2043	1191	3	small	small	ADJ
admet-2043	1191	4	interfering	interfere	VERB
admet-2043	1191	5	rna	rna	NOUN
admet-2043	1191	6	to	to	PART
admet-2043	1191	7	inhibit	inhibit	VERB
admet-2043	1191	8	vascular	vascular	ADJ
admet-2043	1191	9	endothelial	endothelial	ADJ
admet-2043	1191	10	growth	growth	NOUN
admet-2043	1191	11	factor	factor	NOUN
admet-2043	1191	12	in	in	ADP
admet-2043	1191	13	zebrafish	zebrafish	ADJ
admet-2043	1191	14	using	use	VERB
admet-2043	1191	15	natural	natural	ADJ
admet-2043	1191	16	brain	brain	NOUN
admet-2043	1191	17	endothelia	endothelia	PROPN
admet-2043	1191	18	cellhttps://doi.org/10.1016/j.jconrel.2007.05.026	cellhttps://doi.org/10.1016/j.jconrel.2007.05.026	PROPN
admet-2043	1191	19	https://doi.org/10.1007/s11095-011-0641-0	https://doi.org/10.1007/s11095-011-0641-0	NUM
admet-2043	1191	20	https://doi.org/10.1016/j.jconrel.2011.02.022	https://doi.org/10.1016/j.jconrel.2011.02.022	NOUN
admet-2043	1191	21	https://doi.org/10.1016/j.ejpb.2011.10.012	https://doi.org/10.1016/j.ejpb.2011.10.012	PROPN
admet-2043	1191	22	https://doi.org/10.2174/2211738510666220303160414	https://doi.org/10.2174/2211738510666220303160414	PROPN
admet-2043	1192	1	https://doi.org/10.1016/b978-0-12-817909-3.00014-5	https://doi.org/10.1016/b978-0-12-817909-3.00014-5	X
admet-2043	1192	2	https://doi.org/10.1016/j.ijpharm.2017.05.015	https://doi.org/10.1016/j.ijpharm.2017.05.015	NOUN
admet-2043	1192	3	https://doi.org/10.1186/s12951-018-0340-7	https://doi.org/10.1186/s12951-018-0340-7	NUM
admet-2043	1192	4	https://doi.org/10.1021/acsomega.0c01592	https://doi.org/10.1021/acsomega.0c01592	NOUN
admet-2043	1192	5	https://doi.org/10.2174/1389450115666140804124808	https://doi.org/10.2174/1389450115666140804124808	NOUN
admet-2043	1193	1	https://doi.org/10.3389/fnagi.2019.00373	https://doi.org/10.3389/fnagi.2019.00373	PROPN
admet-2043	1193	2	https://doi.org/10.1007/s11051-020-04831-9	https://doi.org/10.1007/s11051-020-04831-9	NUM
admet-2043	1193	3	https://doi.org/10.4103/1673-5374.369096	https://doi.org/10.4103/1673-5374.369096	PROPN
admet-2043	1193	4	admet	admet	PROPN
admet-2043	1193	5	&	&	CCONJ
admet-2043	1193	6	dmpk	dmpk	PROPN
admet-2043	1193	7	12(1	12(1	PROPN
admet-2043	1193	8	)	)	PUNCT
admet-2043	1193	9	(	(	PUNCT
admet-2043	1193	10	2024	2024	NUM
admet-2043	1193	11	)	)	PUNCT
admet-2043	1193	12	63	63	NUM
admet-2043	1193	13	-	-	SYM
admet-2043	1193	14	105	105	NUM
admet-2043	1193	15	nanomaterials	nanomaterial	NOUN
admet-2043	1193	16	as	as	ADP
admet-2043	1193	17	drug	drug	NOUN
admet-2043	1193	18	delivery	delivery	NOUN
admet-2043	1193	19	agents	agent	NOUN
admet-2043	1193	20	for	for	ADP
admet-2043	1193	21	overcoming	overcome	VERB
admet-2043	1193	22	bbb	bbb	PROPN
admet-2043	1193	23	doi	doi	NOUN
admet-2043	1193	24	:	:	PUNCT
admet-2043	1193	25	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1193	26	99	99	NUM
admet-2043	1193	27	secreted	secrete	VERB
admet-2043	1193	28	exosome	exosome	NOUN
admet-2043	1193	29	nanovesicles	nanovesicle	NOUN
admet-2043	1193	30	for	for	ADP
admet-2043	1193	31	the	the	DET
admet-2043	1193	32	treatment	treatment	NOUN
admet-2043	1193	33	of	of	ADP
admet-2043	1193	34	brain	brain	NOUN
admet-2043	1193	35	cancer	cancer	NOUN
admet-2043	1193	36	.	.	PUNCT
admet-2043	1194	1	aaps	aap	NOUN
admet-2043	1194	2	journal	journal	PROPN
admet-2043	1194	3	19	19	NUM
admet-2043	1194	4	(	(	PUNCT
admet-2043	1194	5	2017	2017	NUM
admet-2043	1194	6	)	)	PUNCT
admet-2043	1194	7	475486	475486	NUM
admet-2043	1194	8	.	.	PUNCT
admet-2043	1195	1	https://doi.org/10.1208/s12248-016-0015-y	https://doi.org/10.1208/s12248-016-0015-y	NOUN
admet-2043	1195	2	.	.	PUNCT
admet-2043	1196	1	[	[	X
admet-2043	1196	2	111	111	NUM
admet-2043	1196	3	]	]	PUNCT
admet-2043	1196	4	l.	l.	PROPN
admet-2043	1196	5	bors	bors	PROPN
admet-2043	1196	6	,	,	PUNCT
admet-2043	1196	7	f.	f.	PROPN
admet-2043	1196	8	erdő	erdő	PROPN
admet-2043	1196	9	.	.	PUNCT
admet-2043	1197	1	overcoming	overcome	VERB
admet-2043	1197	2	the	the	DET
admet-2043	1197	3	blood	blood	NOUN
admet-2043	1197	4	–	–	PUNCT
admet-2043	1197	5	brain	brain	NOUN
admet-2043	1197	6	barrier	barrier	NOUN
admet-2043	1197	7	.	.	PUNCT
admet-2043	1198	1	challenges	challenge	NOUN
admet-2043	1198	2	and	and	CCONJ
admet-2043	1198	3	tricks	trick	NOUN
admet-2043	1198	4	for	for	ADP
admet-2043	1198	5	cns	cns	NOUN
admet-2043	1198	6	drug	drug	NOUN
admet-2043	1198	7	delivery	delivery	NOUN
admet-2043	1198	8	.	.	PUNCT
admet-2043	1199	1	scientia	scientia	PROPN
admet-2043	1199	2	pharmaceutica	pharmaceutica	PROPN
admet-2043	1199	3	87	87	NUM
admet-2043	1199	4	(	(	PUNCT
admet-2043	1199	5	2019	2019	NUM
admet-2043	1199	6	)	)	PUNCT
admet-2043	1199	7	6	6	NUM
admet-2043	1199	8	.	.	X
admet-2043	1199	9	https://doi.org/10.3390/scipharm87010006	https://doi.org/10.3390/scipharm87010006	NOUN
admet-2043	1199	10	.	.	PUNCT
admet-2043	1200	1	[	[	X
admet-2043	1200	2	112	112	NUM
admet-2043	1200	3	]	]	PUNCT
admet-2043	1200	4	a.	a.	NOUN
admet-2043	1200	5	bhowmik	bhowmik	PROPN
admet-2043	1200	6	,	,	PUNCT
admet-2043	1200	7	s.	s.	PROPN
admet-2043	1200	8	chakravarti	chakravarti	PROPN
admet-2043	1200	9	,	,	PUNCT
admet-2043	1200	10	a.	a.	PROPN
admet-2043	1200	11	ghosh	ghosh	PROPN
admet-2043	1200	12	,	,	PUNCT
admet-2043	1200	13	r.	r.	PROPN
admet-2043	1200	14	shaw	shaw	PROPN
admet-2043	1200	15	,	,	PUNCT
admet-2043	1200	16	s.	s.	PROPN
admet-2043	1200	17	bhandary	bhandary	PROPN
admet-2043	1200	18	,	,	PUNCT
admet-2043	1201	1	s.	s.	PROPN
admet-2043	1201	2	bhattacharyya	bhattacharyya	PROPN
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admet-2043	1201	4	p.c	p.c	PROPN
admet-2043	1201	5	.	.	PROPN
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admet-2043	1201	7	,	,	PUNCT
admet-2043	1201	8	m.k	m.k	PROPN
admet-2043	1201	9	.	.	PROPN
admet-2043	1201	10	ghosh	ghosh	PROPN
admet-2043	1201	11	.	.	PUNCT
admet-2043	1202	1	anti	anti	ADJ
admet-2043	1202	2	-	-	ADJ
admet-2043	1202	3	sstr2	sstr2	ADJ
admet-2043	1202	4	peptide	peptide	NOUN
admet-2043	1202	5	based	base	VERB
admet-2043	1202	6	targeted	target	VERB
admet-2043	1202	7	delivery	delivery	NOUN
admet-2043	1202	8	of	of	ADP
admet-2043	1202	9	potent	potent	ADJ
admet-2043	1202	10	plga	plga	NOUN
admet-2043	1202	11	encapsulated	encapsulate	VERB
admet-2043	1202	12	3,3'diindolylmethane	3,3'diindolylmethane	NUM
admet-2043	1202	13	nanoparticles	nanoparticle	NOUN
admet-2043	1202	14	through	through	ADP
admet-2043	1202	15	blood	blood	NOUN
admet-2043	1202	16	brain	brain	NOUN
admet-2043	1202	17	barrier	barrier	NOUN
admet-2043	1202	18	prevents	prevent	VERB
admet-2043	1202	19	glioma	glioma	NOUN
admet-2043	1202	20	progression	progression	NOUN
admet-2043	1202	21	.	.	PUNCT
admet-2043	1203	1	oncotarget	oncotarget	NOUN
admet-2043	1203	2	8	8	NUM
admet-2043	1203	3	(	(	PUNCT
admet-2043	1203	4	2017	2017	NUM
admet-2043	1203	5	)	)	PUNCT
admet-2043	1203	6	65339	65339	NUM
admet-2043	1203	7	-	-	SYM
admet-2043	1203	8	65358	65358	NUM
admet-2043	1203	9	.	.	PUNCT
admet-2043	1204	1	https://doi.org/10.18632/oncotarget.18689	https://doi.org/10.18632/oncotarget.18689	NOUN
admet-2043	1204	2	.	.	PUNCT
admet-2043	1205	1	[	[	X
admet-2043	1205	2	113	113	NUM
admet-2043	1205	3	]	]	PUNCT
admet-2043	1205	4	m.	m.	NOUN
admet-2043	1205	5	saeedi	saeedi	PROPN
admet-2043	1205	6	,	,	PUNCT
admet-2043	1205	7	m.	m.	NOUN
admet-2043	1205	8	eslamifar	eslamifar	ADV
admet-2043	1205	9	,	,	PUNCT
admet-2043	1205	10	k.	k.	PROPN
admet-2043	1205	11	khezri	khezri	PROPN
admet-2043	1205	12	,	,	PUNCT
admet-2043	1205	13	s.m	s.m	PROPN
admet-2043	1205	14	.	.	PROPN
admet-2043	1205	15	dizaj	dizaj	PROPN
admet-2043	1205	16	.	.	PUNCT
admet-2043	1206	1	applications	application	NOUN
admet-2043	1206	2	of	of	ADP
admet-2043	1206	3	nanotechnology	nanotechnology	NOUN
admet-2043	1206	4	in	in	ADP
admet-2043	1206	5	drug	drug	NOUN
admet-2043	1206	6	delivery	delivery	NOUN
admet-2043	1206	7	to	to	ADP
admet-2043	1206	8	the	the	DET
admet-2043	1206	9	central	central	ADJ
admet-2043	1206	10	nervous	nervous	ADJ
admet-2043	1206	11	system	system	NOUN
admet-2043	1206	12	.	.	PUNCT
admet-2043	1207	1	biomedicine	biomedicine	NOUN
admet-2043	1207	2	and	and	CCONJ
admet-2043	1207	3	pharmacotherapy	pharmacotherapy	NOUN
admet-2043	1207	4	111	111	NUM
admet-2043	1207	5	(	(	PUNCT
admet-2043	1207	6	2019	2019	NUM
admet-2043	1207	7	)	)	PUNCT
admet-2043	1207	8	666	666	NUM
admet-2043	1207	9	-	-	SYM
admet-2043	1207	10	675	675	NUM
admet-2043	1207	11	.	.	PUNCT
admet-2043	1208	1	https://doi.org/10.1016/j.biopha.2018.12.133	https://doi.org/10.1016/j.biopha.2018.12.133	PROPN
admet-2043	1208	2	.	.	PUNCT
admet-2043	1209	1	[	[	X
admet-2043	1209	2	114	114	NUM
admet-2043	1209	3	]	]	X
admet-2043	1209	4	r.s	r.s	PROPN
admet-2043	1209	5	.	.	PROPN
admet-2043	1209	6	dhanikula	dhanikula	PROPN
admet-2043	1209	7	,	,	PUNCT
admet-2043	1209	8	t.	t.	PROPN
admet-2043	1209	9	hammady	hammady	PROPN
admet-2043	1209	10	,	,	PUNCT
admet-2043	1209	11	p.	p.	PROPN
admet-2043	1209	12	hildgen	hildgen	PROPN
admet-2043	1209	13	.	.	PUNCT
admet-2043	1210	1	on	on	ADP
admet-2043	1210	2	the	the	DET
admet-2043	1210	3	mechanism	mechanism	NOUN
admet-2043	1210	4	and	and	CCONJ
admet-2043	1210	5	dynamics	dynamic	NOUN
admet-2043	1210	6	of	of	ADP
admet-2043	1210	7	uptake	uptake	NOUN
admet-2043	1210	8	and	and	CCONJ
admet-2043	1210	9	permeation	permeation	NOUN
admet-2043	1210	10	of	of	ADP
admet-2043	1210	11	polyether	polyether	NOUN
admet-2043	1210	12	-	-	PUNCT
admet-2043	1210	13	copolyester	copolyester	NOUN
admet-2043	1210	14	dendrimers	dendrimer	NOUN
admet-2043	1210	15	across	across	ADP
admet-2043	1210	16	an	an	DET
admet-2043	1210	17	in	in	ADP
admet-2043	1210	18	vitro	vitro	X
admet-2043	1210	19	blood	blood	NOUN
admet-2043	1210	20	-	-	PUNCT
admet-2043	1210	21	brain	brain	NOUN
admet-2043	1210	22	barrier	barrier	NOUN
admet-2043	1210	23	model	model	NOUN
admet-2043	1210	24	.	.	PUNCT
admet-2043	1211	1	journal	journal	PROPN
admet-2043	1211	2	of	of	ADP
admet-2043	1211	3	pharmaceutical	pharmaceutical	ADJ
admet-2043	1211	4	sciences	science	NOUN
admet-2043	1211	5	98	98	NUM
admet-2043	1211	6	(	(	PUNCT
admet-2043	1211	7	2009	2009	NUM
admet-2043	1211	8	)	)	PUNCT
admet-2043	1211	9	3748	3748	NUM
admet-2043	1211	10	-	-	SYM
admet-2043	1211	11	3760	3760	NUM
admet-2043	1211	12	.	.	PUNCT
admet-2043	1212	1	https://doi.org/10.1002/jps.21669	https://doi.org/10.1002/jps.21669	PROPN
admet-2043	1212	2	.	.	PUNCT
admet-2043	1213	1	[	[	X
admet-2043	1213	2	115	115	NUM
admet-2043	1213	3	]	]	X
admet-2043	1213	4	d.	d.	PROPN
admet-2043	1213	5	furtado	furtado	PROPN
admet-2043	1213	6	,	,	PUNCT
admet-2043	1213	7	m.	m.	NOUN
admet-2043	1213	8	bjornmalm	bjornmalm	PROPN
admet-2043	1213	9	,	,	PUNCT
admet-2043	1213	10	s.	s.	PROPN
admet-2043	1213	11	ayton	ayton	PROPN
admet-2043	1213	12	,	,	PUNCT
admet-2043	1213	13	a.i	a.i	PROPN
admet-2043	1213	14	.	.	PROPN
admet-2043	1213	15	bush	bush	PROPN
admet-2043	1213	16	,	,	PUNCT
admet-2043	1213	17	k.	k.	PROPN
admet-2043	1213	18	kempe	kempe	PROPN
admet-2043	1213	19	,	,	PUNCT
admet-2043	1213	20	f.	f.	PROPN
admet-2043	1213	21	caruso	caruso	PROPN
admet-2043	1213	22	.	.	PUNCT
admet-2043	1214	1	overcoming	overcome	VERB
admet-2043	1214	2	the	the	DET
admet-2043	1214	3	blood	blood	NOUN
admet-2043	1214	4	-	-	PUNCT
admet-2043	1214	5	brain	brain	NOUN
admet-2043	1214	6	barrier	barrier	NOUN
admet-2043	1214	7	:	:	PUNCT
admet-2043	1214	8	the	the	DET
admet-2043	1214	9	role	role	NOUN
admet-2043	1214	10	of	of	ADP
admet-2043	1214	11	nanomaterials	nanomaterial	NOUN
admet-2043	1214	12	in	in	ADP
admet-2043	1214	13	treating	treat	VERB
admet-2043	1214	14	neurological	neurological	ADJ
admet-2043	1214	15	diseases	disease	NOUN
admet-2043	1214	16	.	.	PUNCT
admet-2043	1215	1	advanced	advanced	ADJ
admet-2043	1215	2	materials	material	NOUN
admet-2043	1215	3	30	30	NUM
admet-2043	1215	4	(	(	PUNCT
admet-2043	1215	5	2018	2018	NUM
admet-2043	1215	6	)	)	PUNCT
admet-2043	1215	7	e1801362	e1801362	PROPN
admet-2043	1215	8	.	.	PUNCT
admet-2043	1216	1	https://doi.org/10.1002/adma.201801362	https://doi.org/10.1002/adma.201801362	NOUN
admet-2043	1216	2	.	.	PUNCT
admet-2043	1217	1	[	[	X
admet-2043	1217	2	116	116	X
admet-2043	1217	3	]	]	X
admet-2043	1217	4	y.	y.	PROPN
admet-2043	1217	5	zhu	zhu	PROPN
admet-2043	1217	6	,	,	PUNCT
admet-2043	1217	7	c.	c.	PROPN
admet-2043	1217	8	liu	liu	PROPN
admet-2043	1217	9	,	,	PUNCT
admet-2043	1217	10	z.	z.	PROPN
admet-2043	1217	11	pang	pang	PROPN
admet-2043	1217	12	.	.	PUNCT
admet-2043	1218	1	dendrimer	dendrimer	NOUN
admet-2043	1218	2	-	-	PUNCT
admet-2043	1218	3	based	base	VERB
admet-2043	1218	4	drug	drug	NOUN
admet-2043	1218	5	delivery	delivery	NOUN
admet-2043	1218	6	systems	system	NOUN
admet-2043	1218	7	for	for	ADP
admet-2043	1218	8	brain	brain	NOUN
admet-2043	1218	9	targeting	target	VERB
admet-2043	1218	10	.	.	PUNCT
admet-2043	1219	1	biomolecules	biomolecule	NOUN
admet-2043	1219	2	9	9	NUM
admet-2043	1219	3	(	(	PUNCT
admet-2043	1219	4	2019	2019	NUM
admet-2043	1219	5	)	)	PUNCT
admet-2043	1219	6	.	.	PUNCT
admet-2043	1220	1	https://doi.org/10.3390/biom9120790	https://doi.org/10.3390/biom9120790	PROPN
admet-2043	1220	2	.	.	PUNCT
admet-2043	1221	1	[	[	X
admet-2043	1221	2	117	117	NUM
admet-2043	1221	3	]	]	X
admet-2043	1221	4	a.r	a.r	PROPN
admet-2043	1221	5	.	.	PROPN
admet-2043	1221	6	menjoge	menjoge	PROPN
admet-2043	1221	7	,	,	PUNCT
admet-2043	1221	8	r.m	r.m	PROPN
admet-2043	1221	9	.	.	PROPN
admet-2043	1221	10	kannan	kannan	PROPN
admet-2043	1221	11	,	,	PUNCT
admet-2043	1221	12	d.a	d.a	PROPN
admet-2043	1221	13	.	.	PROPN
admet-2043	1221	14	tomalia	tomalia	PROPN
admet-2043	1221	15	.	.	PUNCT
admet-2043	1221	16	dendrimer	dendrimer	NOUN
admet-2043	1221	17	-	-	PUNCT
admet-2043	1221	18	based	base	VERB
admet-2043	1221	19	drug	drug	NOUN
admet-2043	1221	20	and	and	CCONJ
admet-2043	1221	21	imaging	imaging	NOUN
admet-2043	1221	22	conjugates	conjugate	NOUN
admet-2043	1221	23	:	:	PUNCT
admet-2043	1221	24	design	design	NOUN
admet-2043	1221	25	considerations	consideration	NOUN
admet-2043	1221	26	for	for	ADP
admet-2043	1221	27	nanomedical	nanomedical	ADJ
admet-2043	1221	28	applications	application	NOUN
admet-2043	1221	29	.	.	PUNCT
admet-2043	1222	1	drug	drug	NOUN
admet-2043	1222	2	discovery	discovery	PROPN
admet-2043	1222	3	today	today	NOUN
admet-2043	1222	4	15	15	NUM
admet-2043	1222	5	(	(	PUNCT
admet-2043	1222	6	2010	2010	NUM
admet-2043	1222	7	)	)	PUNCT
admet-2043	1222	8	171	171	NUM
admet-2043	1222	9	-	-	SYM
admet-2043	1222	10	185	185	NUM
admet-2043	1222	11	.	.	PUNCT
admet-2043	1223	1	https://doi.org/10.1016/j.drudis.2010.01.009	https://doi.org/10.1016/j.drudis.2010.01.009	NOUN
admet-2043	1223	2	.	.	PUNCT
admet-2043	1224	1	[	[	X
admet-2043	1224	2	118	118	NUM
admet-2043	1224	3	]	]	X
admet-2043	1224	4	r.	r.	PROPN
admet-2043	1224	5	duncan	duncan	PROPN
admet-2043	1224	6	,	,	PUNCT
admet-2043	1224	7	l.	l.	PROPN
admet-2043	1224	8	izzo	izzo	PROPN
admet-2043	1224	9	.	.	PUNCT
admet-2043	1224	10	dendrimer	dendrimer	PROPN
admet-2043	1224	11	biocompatibility	biocompatibility	NOUN
admet-2043	1224	12	and	and	CCONJ
admet-2043	1224	13	toxicity	toxicity	NOUN
admet-2043	1224	14	.	.	PUNCT
admet-2043	1225	1	advanced	advanced	ADJ
admet-2043	1225	2	drug	drug	NOUN
admet-2043	1225	3	delivery	delivery	NOUN
admet-2043	1225	4	reviews	review	VERB
admet-2043	1225	5	57	57	NUM
admet-2043	1225	6	(	(	PUNCT
admet-2043	1225	7	2005	2005	NUM
admet-2043	1225	8	)	)	PUNCT
admet-2043	1225	9	2215	2215	NUM
admet-2043	1225	10	-	-	SYM
admet-2043	1225	11	2237	2237	NUM
admet-2043	1225	12	.	.	PUNCT
admet-2043	1226	1	https://doi.org/10.1016/j.addr.2005.09.019	https://doi.org/10.1016/j.addr.2005.09.019	X
admet-2043	1226	2	.	.	PUNCT
admet-2043	1227	1	[	[	X
admet-2043	1227	2	119	119	NUM
admet-2043	1227	3	]	]	X
admet-2043	1227	4	v.p	v.p	PROPN
admet-2043	1227	5	.	.	PROPN
admet-2043	1227	6	torchilin	torchilin	PROPN
admet-2043	1227	7	.	.	PUNCT
admet-2043	1228	1	recent	recent	ADJ
admet-2043	1228	2	advances	advance	NOUN
admet-2043	1228	3	with	with	ADP
admet-2043	1228	4	liposomes	liposome	NOUN
admet-2043	1228	5	as	as	ADP
admet-2043	1228	6	pharmaceutical	pharmaceutical	NOUN
admet-2043	1228	7	carriers	carrier	NOUN
admet-2043	1228	8	.	.	PUNCT
admet-2043	1229	1	nature	nature	NOUN
admet-2043	1229	2	reviews	review	VERB
admet-2043	1229	3	drug	drug	NOUN
admet-2043	1229	4	discovery	discovery	NOUN
admet-2043	1229	5	4	4	NUM
admet-2043	1229	6	(	(	PUNCT
admet-2043	1229	7	2005	2005	NUM
admet-2043	1229	8	)	)	PUNCT
admet-2043	1229	9	145	145	NUM
admet-2043	1229	10	-	-	SYM
admet-2043	1229	11	160	160	NUM
admet-2043	1229	12	.	.	PUNCT
admet-2043	1229	13	https://doi.org/10.1038/nrd1632	https://doi.org/10.1038/nrd1632	PROPN
admet-2043	1229	14	.	.	PUNCT
admet-2043	1230	1	[	[	X
admet-2043	1230	2	120	120	NUM
admet-2043	1230	3	]	]	SYM
admet-2043	1230	4	d.b	d.b	PROPN
admet-2043	1230	5	.	.	PROPN
admet-2043	1230	6	vieira	vieira	PROPN
admet-2043	1230	7	,	,	PUNCT
admet-2043	1230	8	l.f	l.f	PROPN
admet-2043	1230	9	.	.	PROPN
admet-2043	1230	10	gamarra	gamarra	NOUN
admet-2043	1230	11	.	.	PUNCT
admet-2043	1231	1	getting	get	VERB
admet-2043	1231	2	into	into	ADP
admet-2043	1231	3	the	the	DET
admet-2043	1231	4	brain	brain	NOUN
admet-2043	1231	5	:	:	PUNCT
admet-2043	1231	6	liposome	liposome	NOUN
admet-2043	1231	7	-	-	PUNCT
admet-2043	1231	8	based	base	VERB
admet-2043	1231	9	strategies	strategy	NOUN
admet-2043	1231	10	for	for	ADP
admet-2043	1231	11	effective	effective	ADJ
admet-2043	1231	12	drug	drug	NOUN
admet-2043	1231	13	delivery	delivery	NOUN
admet-2043	1231	14	across	across	ADP
admet-2043	1231	15	the	the	DET
admet-2043	1231	16	blood	blood	NOUN
admet-2043	1231	17	-	-	PUNCT
admet-2043	1231	18	brain	brain	NOUN
admet-2043	1231	19	barrier	barrier	NOUN
admet-2043	1231	20	.	.	PUNCT
admet-2043	1232	1	international	international	ADJ
admet-2043	1232	2	journal	journal	NOUN
admet-2043	1232	3	of	of	ADP
admet-2043	1232	4	nanomedicine	nanomedicine	ADJ
admet-2043	1232	5	11	11	NUM
admet-2043	1232	6	(	(	PUNCT
admet-2043	1232	7	2016	2016	NUM
admet-2043	1232	8	)	)	PUNCT
admet-2043	1232	9	53815414	53815414	NUM
admet-2043	1232	10	.	.	PUNCT
admet-2043	1233	1	https://doi.org/10.2147/ijn.s117210	https://doi.org/10.2147/ijn.s117210	X
admet-2043	1233	2	.	.	PUNCT
admet-2043	1234	1	[	[	X
admet-2043	1234	2	121	121	NUM
admet-2043	1234	3	]	]	X
admet-2043	1234	4	u.j	u.j	PROPN
admet-2043	1234	5	.	.	PROPN
admet-2043	1234	6	kim	kim	PROPN
admet-2043	1234	7	,	,	PUNCT
admet-2043	1234	8	j.	j.	PROPN
admet-2043	1234	9	park	park	PROPN
admet-2043	1234	10	,	,	PUNCT
admet-2043	1234	11	h.j	h.j	PROPN
admet-2043	1234	12	.	.	PROPN
admet-2043	1234	13	kim	kim	PROPN
admet-2043	1234	14	,	,	PUNCT
admet-2043	1234	15	m.	m.	PROPN
admet-2043	1234	16	wada	wada	PROPN
admet-2043	1234	17	,	,	PUNCT
admet-2043	1234	18	d.l	d.l	PROPN
admet-2043	1234	19	.	.	PROPN
admet-2043	1234	20	kaplan	kaplan	PROPN
admet-2043	1234	21	.	.	PUNCT
admet-2043	1235	1	three	three	NUM
admet-2043	1235	2	-	-	PUNCT
admet-2043	1235	3	dimensional	dimensional	ADJ
admet-2043	1235	4	aqueous	aqueous	ADJ
admet-2043	1235	5	-	-	PUNCT
admet-2043	1235	6	derived	derive	VERB
admet-2043	1235	7	biomaterial	biomaterial	ADJ
admet-2043	1235	8	scaffolds	scaffold	NOUN
admet-2043	1235	9	from	from	ADP
admet-2043	1235	10	silk	silk	NOUN
admet-2043	1235	11	fibroin	fibroin	NOUN
admet-2043	1235	12	.	.	PUNCT
admet-2043	1236	1	biomaterials	biomaterial	NOUN
admet-2043	1236	2	26	26	NUM
admet-2043	1236	3	(	(	PUNCT
admet-2043	1236	4	2005	2005	NUM
admet-2043	1236	5	)	)	PUNCT
admet-2043	1236	6	2775	2775	NUM
admet-2043	1236	7	-	-	SYM
admet-2043	1236	8	2785	2785	NUM
admet-2043	1236	9	.	.	PUNCT
admet-2043	1237	1	https://doi.org/10.1016/j.biomaterials.2004.07.044	https://doi.org/10.1016/j.biomaterials.2004.07.044	PROPN
admet-2043	1237	2	.	.	PUNCT
admet-2043	1238	1	[	[	X
admet-2043	1238	2	122	122	NUM
admet-2043	1238	3	]	]	X
admet-2043	1238	4	j.	j.	PROPN
admet-2043	1238	5	akbari	akbari	PROPN
admet-2043	1238	6	,	,	PUNCT
admet-2043	1238	7	m.	m.	NOUN
admet-2043	1238	8	saeedi	saeedi	PROPN
admet-2043	1238	9	,	,	PUNCT
admet-2043	1238	10	k.	k.	PROPN
admet-2043	1238	11	morteza	morteza	PROPN
admet-2043	1238	12	-	-	PUNCT
admet-2043	1238	13	semnani	semnani	PROPN
admet-2043	1238	14	,	,	PUNCT
admet-2043	1238	15	s.s	s.s	PROPN
admet-2043	1238	16	.	.	PROPN
admet-2043	1238	17	rostamkalaei	rostamkalaei	PROPN
admet-2043	1238	18	,	,	PUNCT
admet-2043	1238	19	m.	m.	NOUN
admet-2043	1238	20	asadi	asadi	PROPN
admet-2043	1238	21	,	,	PUNCT
admet-2043	1238	22	k.	k.	PROPN
admet-2043	1238	23	asare	asare	PROPN
admet-2043	1238	24	-	-	PUNCT
admet-2043	1238	25	addo	addo	PROPN
admet-2043	1238	26	,	,	PUNCT
admet-2043	1238	27	a.	a.	PROPN
admet-2043	1238	28	nokhodchi	nokhodchi	PROPN
admet-2043	1238	29	.	.	PUNCT
admet-2043	1239	1	the	the	DET
admet-2043	1239	2	design	design	NOUN
admet-2043	1239	3	of	of	ADP
admet-2043	1239	4	naproxen	naproxen	NOUN
admet-2043	1239	5	solid	solid	ADJ
admet-2043	1239	6	lipid	lipid	NOUN
admet-2043	1239	7	nanoparticles	nanoparticle	NOUN
admet-2043	1239	8	to	to	PART
admet-2043	1239	9	target	target	VERB
admet-2043	1239	10	skin	skin	NOUN
admet-2043	1239	11	layers	layer	NOUN
admet-2043	1239	12	.	.	PUNCT
admet-2043	1240	1	colloids	colloid	NOUN
admet-2043	1240	2	and	and	CCONJ
admet-2043	1240	3	surfaces	surface	NOUN
admet-2043	1240	4	b	b	NUM
admet-2043	1240	5	:	:	PUNCT
admet-2043	1240	6	biointerfaces	biointerface	NOUN
admet-2043	1240	7	145	145	NUM
admet-2043	1240	8	(	(	PUNCT
admet-2043	1240	9	2016	2016	NUM
admet-2043	1240	10	)	)	PUNCT
admet-2043	1240	11	626	626	NUM
admet-2043	1240	12	-	-	SYM
admet-2043	1240	13	633	633	NUM
admet-2043	1240	14	.	.	PUNCT
admet-2043	1241	1	https://doi.org/10.1016/j.colsurfb.2016.05.064	https://doi.org/10.1016/j.colsurfb.2016.05.064	NOUN
admet-2043	1241	2	.	.	PUNCT
admet-2043	1242	1	[	[	X
admet-2043	1242	2	123	123	NUM
admet-2043	1242	3	]	]	X
admet-2043	1242	4	h.r	h.r	PROPN
admet-2043	1242	5	.	.	PROPN
admet-2043	1242	6	kelidari	kelidari	PROPN
admet-2043	1242	7	,	,	PUNCT
admet-2043	1242	8	m.	m.	NOUN
admet-2043	1242	9	saeedi	saeedi	PROPN
admet-2043	1242	10	,	,	PUNCT
admet-2043	1242	11	j.	j.	PROPN
admet-2043	1242	12	akbari	akbari	PROPN
admet-2043	1242	13	,	,	PUNCT
admet-2043	1242	14	k.	k.	PROPN
admet-2043	1242	15	morteza	morteza	PROPN
admet-2043	1242	16	-	-	PUNCT
admet-2043	1242	17	semnani	semnani	PROPN
admet-2043	1242	18	,	,	PUNCT
admet-2043	1242	19	p.	p.	NOUN
admet-2043	1242	20	gill	gill	PROPN
admet-2043	1242	21	,	,	PUNCT
admet-2043	1242	22	h.	h.	PROPN
admet-2043	1242	23	valizadeh	valizadeh	PROPN
admet-2043	1242	24	,	,	PUNCT
admet-2043	1242	25	a.	a.	PROPN
admet-2043	1242	26	nokhodchi	nokhodchi	PROPN
admet-2043	1242	27	.	.	PUNCT
admet-2043	1243	1	formulation	formulation	NOUN
admet-2043	1243	2	optimization	optimization	NOUN
admet-2043	1243	3	and	and	CCONJ
admet-2043	1243	4	in	in	ADP
admet-2043	1243	5	vitro	vitro	X
admet-2043	1243	6	skin	skin	NOUN
admet-2043	1243	7	penetration	penetration	NOUN
admet-2043	1243	8	of	of	ADP
admet-2043	1243	9	spironolactone	spironolactone	NOUN
admet-2043	1243	10	loaded	load	VERB
admet-2043	1243	11	solid	solid	ADJ
admet-2043	1243	12	lipid	lipid	NOUN
admet-2043	1243	13	nanoparticles	nanoparticle	NOUN
admet-2043	1243	14	.	.	PUNCT
admet-2043	1244	1	colloids	colloid	NOUN
admet-2043	1244	2	and	and	CCONJ
admet-2043	1244	3	surfaces	surface	NOUN
admet-2043	1244	4	b	b	NUM
admet-2043	1244	5	:	:	PUNCT
admet-2043	1244	6	biointerfaces	biointerface	NOUN
admet-2043	1244	7	128	128	NUM
admet-2043	1244	8	(	(	PUNCT
admet-2043	1244	9	2015	2015	NUM
admet-2043	1244	10	)	)	PUNCT
admet-2043	1244	11	473	473	NUM
admet-2043	1244	12	-	-	SYM
admet-2043	1244	13	479	479	NUM
admet-2043	1244	14	.	.	PUNCT
admet-2043	1245	1	https://doi.org/10.1016/j.colsurfb.2015.02.046	https://doi.org/10.1016/j.colsurfb.2015.02.046	VERB
admet-2043	1245	2	.	.	PUNCT
admet-2043	1246	1	[	[	X
admet-2043	1246	2	124	124	NUM
admet-2043	1246	3	]	]	X
admet-2043	1246	4	a.v	a.v	PROPN
admet-2043	1246	5	.	.	PROPN
admet-2043	1246	6	kabanov	kabanov	PROPN
admet-2043	1246	7	,	,	PUNCT
admet-2043	1246	8	a.v	a.v	PROPN
admet-2043	1246	9	.	.	PROPN
admet-2043	1246	10	levashov	levashov	PROPN
admet-2043	1246	11	,	,	PUNCT
admet-2043	1246	12	v.	v.	ADP
admet-2043	1246	13	alakhov	alakhov	PROPN
admet-2043	1246	14	.	.	PUNCT
admet-2043	1247	1	lipid	lipid	NOUN
admet-2043	1247	2	modification	modification	NOUN
admet-2043	1247	3	of	of	ADP
admet-2043	1247	4	proteins	protein	NOUN
admet-2043	1247	5	and	and	CCONJ
admet-2043	1247	6	their	their	PRON
admet-2043	1247	7	membrane	membrane	NOUN
admet-2043	1247	8	transport	transport	NOUN
admet-2043	1247	9	.	.	PUNCT
admet-2043	1248	1	protein	protein	NOUN
admet-2043	1248	2	engineering	engineer	VERB
admet-2043	1248	3	3	3	NUM
admet-2043	1248	4	(	(	PUNCT
admet-2043	1248	5	1989	1989	NUM
admet-2043	1248	6	)	)	PUNCT
admet-2043	1248	7	39	39	NUM
admet-2043	1248	8	-	-	SYM
admet-2043	1248	9	42	42	NUM
admet-2043	1248	10	.	.	PUNCT
admet-2043	1249	1	https://doi.org/10.1093/protein/3.1.39	https://doi.org/10.1093/protein/3.1.39	PROPN
admet-2043	1249	2	.	.	PUNCT
admet-2043	1250	1	[	[	X
admet-2043	1250	2	125	125	NUM
admet-2043	1250	3	]	]	PUNCT
admet-2043	1250	4	a.	a.	NOUN
admet-2043	1250	5	singh	singh	PROPN
admet-2043	1250	6	,	,	PUNCT
admet-2043	1250	7	j.	j.	PROPN
admet-2043	1250	8	kusunose	kusunose	PROPN
admet-2043	1250	9	,	,	PUNCT
admet-2043	1250	10	m.a	m.a	PROPN
admet-2043	1250	11	.	.	PROPN
admet-2043	1250	12	phipps	phipps	PROPN
admet-2043	1250	13	,	,	PUNCT
admet-2043	1250	14	f.	f.	PROPN
admet-2043	1250	15	wang	wang	PROPN
admet-2043	1250	16	,	,	PUNCT
admet-2043	1250	17	l.m	l.m	PROPN
admet-2043	1250	18	.	.	PROPN
admet-2043	1250	19	chen	chen	PROPN
admet-2043	1250	20	,	,	PUNCT
admet-2043	1250	21	c.f	c.f	PROPN
admet-2043	1250	22	.	.	PROPN
admet-2043	1250	23	caskey	caskey	PROPN
admet-2043	1250	24	.	.	PUNCT
admet-2043	1251	1	guiding	guiding	NOUN
admet-2043	1251	2	and	and	CCONJ
admet-2043	1251	3	monitoring	monitoring	NOUN
admet-2043	1251	4	focused	focus	VERB
admet-2043	1251	5	ultrasound	ultrasound	ADJ
admet-2043	1251	6	mediated	mediate	VERB
admet-2043	1251	7	blood	blood	NOUN
admet-2043	1251	8	-	-	PUNCT
admet-2043	1251	9	brain	brain	NOUN
admet-2043	1251	10	barrier	barrier	NOUN
admet-2043	1251	11	opening	opening	NOUN
admet-2043	1251	12	in	in	ADP
admet-2043	1251	13	rats	rat	NOUN
admet-2043	1251	14	using	use	VERB
admet-2043	1251	15	power	power	NOUN
admet-2043	1251	16	doppler	doppler	NOUN
admet-2043	1251	17	imaging	imaging	NOUN
admet-2043	1251	18	and	and	CCONJ
admet-2043	1251	19	passive	passive	ADJ
admet-2043	1251	20	acoustic	acoustic	ADJ
admet-2043	1251	21	mapping	mapping	NOUN
admet-2043	1251	22	.	.	PUNCT
admet-2043	1252	1	scientific	scientific	ADJ
admet-2043	1252	2	reports	report	NOUN
admet-2043	1252	3	12	12	NUM
admet-2043	1252	4	(	(	PUNCT
admet-2043	1252	5	2022	2022	NUM
admet-2043	1252	6	)	)	PUNCT
admet-2043	1252	7	14758	14758	NUM
admet-2043	1252	8	.	.	PUNCT
admet-2043	1253	1	https://doi.org/10.1038/s41598-022-18328-z	https://doi.org/10.1038/s41598-022-18328-z	PROPN
admet-2043	1253	2	.	.	PUNCT
admet-2043	1254	1	[	[	X
admet-2043	1254	2	126	126	NUM
admet-2043	1254	3	]	]	SYM
admet-2043	1254	4	c.m	c.m	PROPN
admet-2043	1254	5	.	.	PROPN
admet-2043	1254	6	wilson	wilson	PROPN
admet-2043	1254	7	,	,	PUNCT
admet-2043	1254	8	a.	a.	NOUN
admet-2043	1254	9	magnaudeix	magnaudeix	NOUN
admet-2043	1254	10	,	,	PUNCT
admet-2043	1254	11	t.	t.	PROPN
admet-2043	1254	12	naves	naves	PROPN
admet-2043	1254	13	,	,	PUNCT
admet-2043	1254	14	f.	f.	PROPN
admet-2043	1254	15	vincent	vincent	PROPN
admet-2043	1254	16	,	,	PUNCT
admet-2043	1254	17	f.	f.	PROPN
admet-2043	1254	18	lalloue	lalloue	PROPN
admet-2043	1254	19	,	,	PUNCT
admet-2043	1254	20	m.o	m.o	PROPN
admet-2043	1254	21	.	.	PROPN
admet-2043	1254	22	jauberteau	jauberteau	PROPN
admet-2043	1254	23	.	.	PUNCT
admet-2043	1255	1	the	the	DET
admet-2043	1255	2	ins	in	NOUN
admet-2043	1255	3	and	and	CCONJ
admet-2043	1255	4	outs	out	NOUN
admet-2043	1255	5	of	of	ADP
admet-2043	1255	6	nanoparticle	nanoparticle	NOUN
admet-2043	1255	7	technology	technology	NOUN
admet-2043	1255	8	in	in	ADP
admet-2043	1255	9	neurodegenerative	neurodegenerative	ADJ
admet-2043	1255	10	diseases	disease	NOUN
admet-2043	1255	11	and	and	CCONJ
admet-2043	1255	12	cancer	cancer	NOUN
admet-2043	1255	13	.	.	PUNCT
admet-2043	1256	1	current	current	ADJ
admet-2043	1256	2	drug	drug	NOUN
admet-2043	1256	3	metabolism	metabolism	NOUN
admet-2043	1256	4	16	16	NUM
admet-2043	1256	5	(	(	PUNCT
admet-2043	1256	6	2015	2015	NUM
admet-2043	1256	7	)	)	PUNCT
admet-2043	1256	8	609	609	NUM
admet-2043	1256	9	-	-	SYM
admet-2043	1256	10	632	632	NUM
admet-2043	1256	11	.	.	PUNCT
admet-2043	1256	12	https://doi.org/10.2174/1389200216666150812121902	https://doi.org/10.2174/1389200216666150812121902	NOUN
admet-2043	1256	13	.	.	PUNCT
admet-2043	1257	1	[	[	X
admet-2043	1257	2	127	127	NUM
admet-2043	1257	3	]	]	X
admet-2043	1257	4	h.	h.	PROPN
admet-2043	1257	5	kafa	kafa	PROPN
admet-2043	1257	6	,	,	PUNCT
admet-2043	1257	7	j.t	j.t	PROPN
admet-2043	1257	8	.	.	PROPN
admet-2043	1257	9	wang	wang	PROPN
admet-2043	1257	10	,	,	PUNCT
admet-2043	1257	11	n.	n.	PROPN
admet-2043	1257	12	rubio	rubio	PROPN
admet-2043	1257	13	,	,	PUNCT
admet-2043	1257	14	k.	k.	PROPN
admet-2043	1257	15	venner	venner	PROPN
admet-2043	1257	16	,	,	PUNCT
admet-2043	1257	17	g.	g.	PROPN
admet-2043	1257	18	anderson	anderson	PROPN
admet-2043	1257	19	,	,	PUNCT
admet-2043	1257	20	e.	e.	PROPN
admet-2043	1257	21	pach	pach	PROPN
admet-2043	1257	22	,	,	PUNCT
admet-2043	1257	23	b.	b.	PROPN
admet-2043	1257	24	ballesteros	ballesteros	PROPN
admet-2043	1257	25	,	,	PUNCT
admet-2043	1257	26	j.e	j.e	PROPN
admet-2043	1257	27	.	.	PROPN
admet-2043	1257	28	preston	preston	PROPN
admet-2043	1257	29	,	,	PUNCT
admet-2043	1257	30	n.j	n.j	PROPN
admet-2043	1257	31	.	.	PROPN
admet-2043	1257	32	abbott	abbott	PROPN
admet-2043	1257	33	,	,	PUNCT
admet-2043	1257	34	k.t	k.t	PROPN
admet-2043	1257	35	.	.	PROPN
admet-2043	1257	36	al	al	PROPN
admet-2043	1257	37	-	-	PUNCT
admet-2043	1257	38	jamal	jamal	PROPN
admet-2043	1257	39	.	.	PUNCT
admet-2043	1258	1	the	the	DET
admet-2043	1258	2	interaction	interaction	NOUN
admet-2043	1258	3	of	of	ADP
admet-2043	1258	4	carbon	carbon	NOUN
admet-2043	1258	5	nanotubes	nanotube	NOUN
admet-2043	1258	6	with	with	ADP
admet-2043	1258	7	an	an	DET
admet-2043	1258	8	in	in	ADP
admet-2043	1258	9	vitro	vitro	X
admet-2043	1258	10	blood	blood	NOUN
admet-2043	1258	11	-	-	PUNCT
admet-2043	1258	12	brain	brain	NOUN
admet-2043	1258	13	barrier	barrier	NOUN
admet-2043	1258	14	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	PUNCT
admet-2043	1258	15	https://doi.org/10.1208/s12248-016-0015-y	https://doi.org/10.1208/s12248-016-0015-y	NOUN
admet-2043	1258	16	https://doi.org/10.3390/scipharm87010006	https://doi.org/10.3390/scipharm87010006	NOUN
admet-2043	1258	17	https://doi.org/10.18632/oncotarget.18689	https://doi.org/10.18632/oncotarget.18689	NOUN
admet-2043	1258	18	https://doi.org/10.1016/j.biopha.2018.12.133	https://doi.org/10.1016/j.biopha.2018.12.133	PROPN
admet-2043	1258	19	https://doi.org/10.1002/jps.21669	https://doi.org/10.1002/jps.21669	PROPN
admet-2043	1258	20	https://doi.org/10.1002/adma.201801362	https://doi.org/10.1002/adma.201801362	NOUN
admet-2043	1258	21	https://doi.org/10.3390/biom9120790	https://doi.org/10.3390/biom9120790	VERB
admet-2043	1258	22	https://doi.org/10.1016/j.drudis.2010.01.009	https://doi.org/10.1016/j.drudis.2010.01.009	NOUN
admet-2043	1258	23	https://doi.org/10.1016/j.addr.2005.09.019	https://doi.org/10.1016/j.addr.2005.09.019	NUM
admet-2043	1258	24	https://doi.org/10.1038/nrd1632	https://doi.org/10.1038/nrd1632	VERB
admet-2043	1258	25	https://doi.org/10.2147/ijn.s117210	https://doi.org/10.2147/ijn.s117210	NOUN
admet-2043	1258	26	https://doi.org/10.1016/j.biomaterials.2004.07.044	https://doi.org/10.1016/j.biomaterials.2004.07.044	PROPN
admet-2043	1258	27	https://doi.org/10.1016/j.colsurfb.2016.05.064	https://doi.org/10.1016/j.colsurfb.2016.05.064	NOUN
admet-2043	1258	28	https://doi.org/10.1016/j.colsurfb.2015.02.046	https://doi.org/10.1016/j.colsurfb.2015.02.046	VERB
admet-2043	1258	29	https://doi.org/10.1093/protein/3.1.39	https://doi.org/10.1093/protein/3.1.39	PROPN
admet-2043	1258	30	https://doi.org/10.1038/s41598-022-18328-z	https://doi.org/10.1038/s41598-022-18328-z	PROPN
admet-2043	1258	31	https://doi.org/10.2174/1389200216666150812121902	https://doi.org/10.2174/1389200216666150812121902	PART
admet-2043	1258	32	m.	m.	NOUN
admet-2043	1259	1	kulkarni	kulkarni	PROPN
admet-2043	1259	2	et	et	PROPN
admet-2043	1259	3	al	al	PROPN
admet-2043	1259	4	.	.	PROPN
admet-2043	1259	5	admet	admet	PROPN
admet-2043	1259	6	&	&	CCONJ
admet-2043	1259	7	dmpk	dmpk	PROPN
admet-2043	1259	8	12(1	12(1	PROPN
admet-2043	1259	9	)	)	PUNCT
admet-2043	1259	10	(	(	PUNCT
admet-2043	1259	11	2024	2024	NUM
admet-2043	1259	12	)	)	PUNCT
admet-2043	1259	13	63	63	NUM
admet-2043	1259	14	-	-	SYM
admet-2043	1259	15	105	105	NUM
admet-2043	1259	16	100	100	NUM
admet-2043	1259	17	model	model	NOUN
admet-2043	1259	18	and	and	CCONJ
admet-2043	1259	19	mouse	mouse	NOUN
admet-2043	1259	20	brain	brain	NOUN
admet-2043	1259	21	in	in	ADP
admet-2043	1259	22	vivo	vivo	NOUN
admet-2043	1259	23	.	.	PUNCT
admet-2043	1260	1	biomaterials	biomaterial	NOUN
admet-2043	1260	2	53	53	NUM
admet-2043	1260	3	(	(	PUNCT
admet-2043	1260	4	2015	2015	NUM
admet-2043	1260	5	)	)	PUNCT
admet-2043	1260	6	437	437	NUM
admet-2043	1260	7	-	-	SYM
admet-2043	1260	8	452	452	NUM
admet-2043	1260	9	.	.	PUNCT
admet-2043	1261	1	https://doi.org/10.1016/j.biomaterials.2015.02.083	https://doi.org/10.1016/j.biomaterials.2015.02.083	PROPN
admet-2043	1261	2	.	.	PUNCT
admet-2043	1262	1	[	[	X
admet-2043	1262	2	128	128	NUM
admet-2043	1262	3	]	]	X
admet-2043	1262	4	s.	s.	PROPN
admet-2043	1262	5	vardharajula	vardharajula	PROPN
admet-2043	1262	6	,	,	PUNCT
admet-2043	1262	7	s.z	s.z	PROPN
admet-2043	1262	8	.	.	PROPN
admet-2043	1262	9	ali	ali	PROPN
admet-2043	1262	10	,	,	PUNCT
admet-2043	1262	11	p.m.	p.m.	NOUN
admet-2043	1262	12	tiwari	tiwari	PROPN
admet-2043	1262	13	,	,	PUNCT
admet-2043	1262	14	e.	e.	PROPN
admet-2043	1262	15	eroglu	eroglu	PROPN
admet-2043	1262	16	,	,	PUNCT
admet-2043	1262	17	k.	k.	PROPN
admet-2043	1262	18	vig	vig	PROPN
admet-2043	1262	19	,	,	PUNCT
admet-2043	1262	20	v.a	v.a	PROPN
admet-2043	1262	21	.	.	PROPN
admet-2043	1262	22	dennis	dennis	PROPN
admet-2043	1262	23	,	,	PUNCT
admet-2043	1262	24	s.r	s.r	PROPN
admet-2043	1262	25	.	.	PROPN
admet-2043	1262	26	singh	singh	PROPN
admet-2043	1262	27	.	.	PUNCT
admet-2043	1263	1	functionalized	functionalize	VERB
admet-2043	1263	2	carbon	carbon	NOUN
admet-2043	1263	3	nanotubes	nanotube	NOUN
admet-2043	1263	4	:	:	PUNCT
admet-2043	1263	5	biomedical	biomedical	ADJ
admet-2043	1263	6	applications	application	NOUN
admet-2043	1263	7	.	.	PUNCT
admet-2043	1264	1	international	international	ADJ
admet-2043	1264	2	journal	journal	PROPN
admet-2043	1264	3	of	of	ADP
admet-2043	1264	4	nanomedicine	nanomedicine	NOUN
admet-2043	1264	5	7	7	NUM
admet-2043	1264	6	(	(	PUNCT
admet-2043	1264	7	2012	2012	NUM
admet-2043	1264	8	)	)	PUNCT
admet-2043	1264	9	53615374	53615374	NUM
admet-2043	1264	10	.	.	PUNCT
admet-2043	1265	1	https://doi.org/10.2147/ijn.s35832	https://doi.org/10.2147/ijn.s35832	X
admet-2043	1265	2	.	.	PUNCT
admet-2043	1266	1	[	[	X
admet-2043	1266	2	129	129	NUM
admet-2043	1266	3	]	]	PUNCT
admet-2043	1266	4	x.	x.	PROPN
admet-2043	1266	5	ma	ma	PROPN
admet-2043	1266	6	,	,	PUNCT
admet-2043	1266	7	l.	l.	PROPN
admet-2043	1266	8	zhong	zhong	PROPN
admet-2043	1266	9	,	,	PUNCT
admet-2043	1266	10	h.	h.	PROPN
admet-2043	1266	11	guo	guo	PROPN
admet-2043	1266	12	,	,	PUNCT
admet-2043	1266	13	y.	y.	PROPN
admet-2043	1266	14	wang	wang	PROPN
admet-2043	1266	15	,	,	PUNCT
admet-2043	1266	16	n.	n.	PROPN
admet-2043	1266	17	gong	gong	PROPN
admet-2043	1266	18	,	,	PUNCT
admet-2043	1266	19	y.	y.	PROPN
admet-2043	1266	20	wang	wang	PROPN
admet-2043	1266	21	,	,	PUNCT
admet-2043	1266	22	j.	j.	PROPN
admet-2043	1266	23	cai	cai	PROPN
admet-2043	1266	24	,	,	PUNCT
admet-2043	1266	25	x.j	x.j	PROPN
admet-2043	1266	26	.	.	PROPN
admet-2043	1266	27	liang	liang	PROPN
admet-2043	1266	28	.	.	PROPN
admet-2043	1266	29	multiwalled	multiwalle	VERB
admet-2043	1266	30	carbon	carbon	NOUN
admet-2043	1266	31	nanotubes	nanotube	NOUN
admet-2043	1266	32	induced	induce	VERB
admet-2043	1266	33	hypotension	hypotension	NOUN
admet-2043	1266	34	by	by	ADP
admet-2043	1266	35	regulating	regulate	VERB
admet-2043	1266	36	the	the	DET
admet-2043	1266	37	central	central	ADJ
admet-2043	1266	38	nervous	nervous	ADJ
admet-2043	1266	39	system	system	NOUN
admet-2043	1266	40	.	.	PUNCT
admet-2043	1267	1	advanced	advanced	ADJ
admet-2043	1267	2	functional	functional	ADJ
admet-2043	1267	3	materials	material	NOUN
admet-2043	1267	4	28	28	NUM
admet-2043	1267	5	(	(	PUNCT
admet-2043	1267	6	2018	2018	NUM
admet-2043	1267	7	)	)	PUNCT
admet-2043	1267	8	.	.	PUNCT
admet-2043	1268	1	https://doi.org/10.1002/adfm.201705479	https://doi.org/10.1002/adfm.201705479	ADJ
admet-2043	1268	2	.	.	PUNCT
admet-2043	1269	1	[	[	X
admet-2043	1269	2	130	130	NUM
admet-2043	1269	3	]	]	SYM
admet-2043	1269	4	l.l	l.l	PROPN
admet-2043	1269	5	.	.	PROPN
admet-2043	1269	6	rubin	rubin	PROPN
admet-2043	1269	7	,	,	PUNCT
admet-2043	1269	8	d.e	d.e	PROPN
admet-2043	1269	9	.	.	PROPN
admet-2043	1269	10	hall	hall	PROPN
admet-2043	1269	11	,	,	PUNCT
admet-2043	1269	12	s.	s.	PROPN
admet-2043	1269	13	porter	porter	PROPN
admet-2043	1269	14	,	,	PUNCT
admet-2043	1269	15	k.	k.	PROPN
admet-2043	1269	16	barbu	barbu	PROPN
admet-2043	1269	17	,	,	PUNCT
admet-2043	1269	18	c.	c.	PROPN
admet-2043	1269	19	cannon	cannon	NOUN
admet-2043	1269	20	,	,	PUNCT
admet-2043	1269	21	h.c	h.c	PROPN
admet-2043	1269	22	.	.	PUNCT
admet-2043	1269	23	horner	horner	PROPN
admet-2043	1269	24	,	,	PUNCT
admet-2043	1269	25	m.	m.	PROPN
admet-2043	1269	26	janatpour	janatpour	PROPN
admet-2043	1269	27	,	,	PUNCT
admet-2043	1269	28	c.w	c.w	PROPN
admet-2043	1269	29	.	.	PROPN
admet-2043	1269	30	liaw	liaw	PROPN
admet-2043	1269	31	,	,	PUNCT
admet-2043	1269	32	k.	k.	PROPN
admet-2043	1269	33	manning	manning	PROPN
admet-2043	1269	34	,	,	PUNCT
admet-2043	1269	35	j.	j.	PROPN
admet-2043	1269	36	morales	morales	PROPN
admet-2043	1269	37	,	,	PUNCT
admet-2043	1269	38	et	et	PROPN
admet-2043	1269	39	al	al	PROPN
admet-2043	1269	40	.	.	PUNCT
admet-2043	1270	1	a	a	DET
admet-2043	1270	2	cell	cell	NOUN
admet-2043	1270	3	culture	culture	NOUN
admet-2043	1270	4	model	model	NOUN
admet-2043	1270	5	of	of	ADP
admet-2043	1270	6	the	the	DET
admet-2043	1270	7	blood	blood	NOUN
admet-2043	1270	8	-	-	PUNCT
admet-2043	1270	9	brain	brain	NOUN
admet-2043	1270	10	barrier	barrier	NOUN
admet-2043	1270	11	.	.	PUNCT
admet-2043	1271	1	journal	journal	NOUN
admet-2043	1271	2	of	of	ADP
admet-2043	1271	3	cell	cell	NOUN
admet-2043	1271	4	biology	biology	NOUN
admet-2043	1271	5	115	115	NUM
admet-2043	1271	6	(	(	PUNCT
admet-2043	1271	7	1991	1991	NUM
admet-2043	1271	8	)	)	PUNCT
admet-2043	1271	9	1725	1725	NUM
admet-2043	1271	10	-	-	SYM
admet-2043	1271	11	1735	1735	NUM
admet-2043	1271	12	.	.	PUNCT
admet-2043	1272	1	https://doi.org/10.1083/jcb.115.6.1725	https://doi.org/10.1083/jcb.115.6.1725	X
admet-2043	1272	2	.	.	PUNCT
admet-2043	1273	1	[	[	X
admet-2043	1273	2	131	131	NUM
admet-2043	1273	3	]	]	X
admet-2043	1273	4	s.b	s.b	PROPN
admet-2043	1273	5	.	.	PROPN
admet-2043	1273	6	pehlivan	pehlivan	PROPN
admet-2043	1273	7	.	.	PUNCT
admet-2043	1274	1	nanotechnology	nanotechnology	PROPN
admet-2043	1274	2	-	-	PUNCT
admet-2043	1274	3	based	base	VERB
admet-2043	1274	4	drug	drug	NOUN
admet-2043	1274	5	delivery	delivery	NOUN
admet-2043	1274	6	systems	system	NOUN
admet-2043	1274	7	for	for	ADP
admet-2043	1274	8	targeting	target	VERB
admet-2043	1274	9	,	,	PUNCT
admet-2043	1274	10	imaging	imaging	NOUN
admet-2043	1274	11	and	and	CCONJ
admet-2043	1274	12	diagnosis	diagnosis	NOUN
admet-2043	1274	13	of	of	ADP
admet-2043	1274	14	neurodegenerative	neurodegenerative	ADJ
admet-2043	1274	15	diseases	disease	NOUN
admet-2043	1274	16	.	.	PUNCT
admet-2043	1275	1	pharmaceutical	pharmaceutical	ADJ
admet-2043	1275	2	research	research	NOUN
admet-2043	1275	3	30	30	NUM
admet-2043	1275	4	(	(	PUNCT
admet-2043	1275	5	2013	2013	NUM
admet-2043	1275	6	)	)	PUNCT
admet-2043	1275	7	2499	2499	NUM
admet-2043	1275	8	-	-	SYM
admet-2043	1275	9	2511	2511	NUM
admet-2043	1275	10	.	.	PUNCT
admet-2043	1276	1	https://doi.org/10.1007/s11095-013-1156-7	https://doi.org/10.1007/s11095-013-1156-7	NUM
admet-2043	1276	2	.	.	PUNCT
admet-2043	1277	1	[	[	X
admet-2043	1277	2	132	132	NUM
admet-2043	1277	3	]	]	PUNCT
admet-2043	1277	4	m.	m.	NOUN
admet-2043	1277	5	bramini	bramini	NOUN
admet-2043	1277	6	,	,	PUNCT
admet-2043	1277	7	d.	d.	PROPN
admet-2043	1277	8	ye	ye	PROPN
admet-2043	1277	9	,	,	PUNCT
admet-2043	1277	10	a.	a.	NOUN
admet-2043	1277	11	hallerbach	hallerbach	PROPN
admet-2043	1277	12	,	,	PUNCT
admet-2043	1277	13	m.	m.	PROPN
admet-2043	1277	14	nic	nic	PROPN
admet-2043	1277	15	raghnaill	raghnaill	PROPN
admet-2043	1277	16	,	,	PUNCT
admet-2043	1277	17	a.	a.	PROPN
admet-2043	1277	18	salvati	salvati	PROPN
admet-2043	1277	19	,	,	PUNCT
admet-2043	1277	20	c.	c.	PROPN
admet-2043	1277	21	aberg	aberg	PROPN
admet-2043	1277	22	,	,	PUNCT
admet-2043	1277	23	k.a	k.a	PROPN
admet-2043	1277	24	.	.	PROPN
admet-2043	1277	25	dawson	dawson	PROPN
admet-2043	1277	26	.	.	PROPN
admet-2043	1277	27	imaging	imaging	NOUN
admet-2043	1277	28	approach	approach	NOUN
admet-2043	1277	29	to	to	ADP
admet-2043	1277	30	mechanistic	mechanistic	ADJ
admet-2043	1277	31	study	study	NOUN
admet-2043	1277	32	of	of	ADP
admet-2043	1277	33	nanoparticle	nanoparticle	NOUN
admet-2043	1277	34	interactions	interaction	NOUN
admet-2043	1277	35	with	with	ADP
admet-2043	1277	36	the	the	DET
admet-2043	1277	37	blood	blood	NOUN
admet-2043	1277	38	-	-	PUNCT
admet-2043	1277	39	brain	brain	NOUN
admet-2043	1277	40	barrier	barrier	NOUN
admet-2043	1277	41	.	.	PUNCT
admet-2043	1278	1	acs	acs	PROPN
admet-2043	1278	2	nano	nano	VERB
admet-2043	1278	3	8	8	NUM
admet-2043	1278	4	(	(	PUNCT
admet-2043	1278	5	2014	2014	NUM
admet-2043	1278	6	)	)	PUNCT
admet-2043	1278	7	4304	4304	NUM
admet-2043	1278	8	-	-	SYM
admet-2043	1278	9	4312	4312	NUM
admet-2043	1278	10	.	.	PUNCT
admet-2043	1279	1	https://doi.org/10.1021/nn5018523	https://doi.org/10.1021/nn5018523	NOUN
admet-2043	1279	2	.	.	PUNCT
admet-2043	1280	1	[	[	X
admet-2043	1280	2	133	133	NUM
admet-2043	1280	3	]	]	X
admet-2043	1280	4	w.m	w.m	PROPN
admet-2043	1280	5	.	.	PROPN
admet-2043	1280	6	pardridge	pardridge	PROPN
admet-2043	1280	7	.	.	PUNCT
admet-2043	1281	1	the	the	DET
admet-2043	1281	2	blood	blood	NOUN
admet-2043	1281	3	-	-	PUNCT
admet-2043	1281	4	brain	brain	NOUN
admet-2043	1281	5	barrier	barrier	NOUN
admet-2043	1281	6	:	:	PUNCT
admet-2043	1281	7	bottleneck	bottleneck	NOUN
admet-2043	1281	8	in	in	ADP
admet-2043	1281	9	brain	brain	NOUN
admet-2043	1281	10	drug	drug	NOUN
admet-2043	1281	11	development	development	NOUN
admet-2043	1281	12	.	.	PUNCT
admet-2043	1282	1	neurorx	neurorx	NOUN
admet-2043	1282	2	2	2	NUM
admet-2043	1282	3	(	(	PUNCT
admet-2043	1282	4	2005	2005	NUM
admet-2043	1282	5	)	)	PUNCT
admet-2043	1282	6	3	3	NUM
admet-2043	1282	7	-	-	SYM
admet-2043	1282	8	14	14	NUM
admet-2043	1282	9	.	.	PUNCT
admet-2043	1283	1	https://doi.org/10.1602/neurorx.2.1.3	https://doi.org/10.1602/neurorx.2.1.3	PROPN
admet-2043	1283	2	.	.	PUNCT
admet-2043	1284	1	[	[	X
admet-2043	1284	2	134	134	NUM
admet-2043	1284	3	]	]	PUNCT
admet-2043	1284	4	s.	s.	PROPN
admet-2043	1284	5	parveen	parveen	PROPN
admet-2043	1284	6	,	,	PUNCT
admet-2043	1284	7	r.	r.	PROPN
admet-2043	1284	8	misra	misra	PROPN
admet-2043	1284	9	,	,	PUNCT
admet-2043	1284	10	s.k	s.k	PROPN
admet-2043	1284	11	.	.	PROPN
admet-2043	1284	12	sahoo	sahoo	PROPN
admet-2043	1284	13	.	.	PUNCT
admet-2043	1284	14	nanoparticles	nanoparticle	NOUN
admet-2043	1284	15	:	:	PUNCT
admet-2043	1284	16	a	a	DET
admet-2043	1284	17	boon	boon	NOUN
admet-2043	1284	18	to	to	ADP
admet-2043	1284	19	drug	drug	NOUN
admet-2043	1284	20	delivery	delivery	NOUN
admet-2043	1284	21	,	,	PUNCT
admet-2043	1284	22	therapeutics	therapeutic	NOUN
admet-2043	1284	23	,	,	PUNCT
admet-2043	1284	24	diagnostics	diagnostic	NOUN
admet-2043	1284	25	and	and	CCONJ
admet-2043	1284	26	imaging	imaging	NOUN
admet-2043	1284	27	.	.	PUNCT
admet-2043	1285	1	nanomedicine	nanomedicine	PROPN
admet-2043	1285	2	:	:	PUNCT
admet-2043	1285	3	nanotechnology	nanotechnology	NOUN
admet-2043	1285	4	,	,	PUNCT
admet-2043	1285	5	biology	biology	NOUN
admet-2043	1285	6	,	,	PUNCT
admet-2043	1285	7	and	and	CCONJ
admet-2043	1285	8	medicine	medicine	NOUN
admet-2043	1285	9	8	8	NUM
admet-2043	1285	10	(	(	PUNCT
admet-2043	1285	11	2012	2012	NUM
admet-2043	1285	12	)	)	PUNCT
admet-2043	1285	13	147	147	NUM
admet-2043	1285	14	-	-	SYM
admet-2043	1285	15	166	166	NUM
admet-2043	1285	16	.	.	PUNCT
admet-2043	1286	1	https://doi.org/10.1016/j.nano.2011.05.016	https://doi.org/10.1016/j.nano.2011.05.016	PROPN
admet-2043	1286	2	.	.	PUNCT
admet-2043	1287	1	[	[	X
admet-2043	1287	2	135	135	NUM
admet-2043	1287	3	]	]	PUNCT
admet-2043	1287	4	j.	j.	PROPN
admet-2043	1287	5	bicker	bicker	PROPN
admet-2043	1287	6	,	,	PUNCT
admet-2043	1287	7	g.	g.	PROPN
admet-2043	1287	8	alves	alves	PROPN
admet-2043	1287	9	,	,	PUNCT
admet-2043	1287	10	a.	a.	PROPN
admet-2043	1287	11	fortuna	fortuna	PROPN
admet-2043	1287	12	,	,	PUNCT
admet-2043	1287	13	a.	a.	NOUN
admet-2043	1287	14	falcao	falcao	PROPN
admet-2043	1287	15	.	.	PUNCT
admet-2043	1288	1	blood	blood	NOUN
admet-2043	1288	2	-	-	PUNCT
admet-2043	1288	3	brain	brain	NOUN
admet-2043	1288	4	barrier	barrier	NOUN
admet-2043	1288	5	models	model	NOUN
admet-2043	1288	6	and	and	CCONJ
admet-2043	1288	7	their	their	PRON
admet-2043	1288	8	relevance	relevance	NOUN
admet-2043	1288	9	for	for	ADP
admet-2043	1288	10	a	a	DET
admet-2043	1288	11	successful	successful	ADJ
admet-2043	1288	12	development	development	NOUN
admet-2043	1288	13	of	of	ADP
admet-2043	1288	14	cns	cns	NOUN
admet-2043	1288	15	drug	drug	NOUN
admet-2043	1288	16	delivery	delivery	NOUN
admet-2043	1288	17	systems	system	NOUN
admet-2043	1288	18	:	:	PUNCT
admet-2043	1288	19	a	a	DET
admet-2043	1288	20	review	review	NOUN
admet-2043	1288	21	.	.	PUNCT
admet-2043	1289	1	european	european	PROPN
admet-2043	1289	2	journal	journal	PROPN
admet-2043	1289	3	of	of	ADP
admet-2043	1289	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	1289	5	and	and	CCONJ
admet-2043	1289	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2043	1289	7	87	87	NUM
admet-2043	1289	8	(	(	PUNCT
admet-2043	1289	9	2014	2014	NUM
admet-2043	1289	10	)	)	PUNCT
admet-2043	1289	11	409	409	NUM
admet-2043	1289	12	-	-	SYM
admet-2043	1289	13	432	432	NUM
admet-2043	1289	14	.	.	PUNCT
admet-2043	1290	1	https://doi.org/10.1016/j.ejpb.2014.03.012	https://doi.org/10.1016/j.ejpb.2014.03.012	NOUN
admet-2043	1290	2	.	.	PUNCT
admet-2043	1291	1	[	[	X
admet-2043	1291	2	136	136	NUM
admet-2043	1291	3	]	]	X
admet-2043	1291	4	e.s	e.s	PROPN
admet-2043	1291	5	.	.	PROPN
admet-2043	1291	6	lippmann	lippmann	PROPN
admet-2043	1291	7	,	,	PUNCT
admet-2043	1291	8	s.m	s.m	PROPN
admet-2043	1291	9	.	.	PROPN
admet-2043	1291	10	azarin	azarin	PROPN
admet-2043	1291	11	,	,	PUNCT
admet-2043	1291	12	j.e	j.e	PROPN
admet-2043	1291	13	.	.	PROPN
admet-2043	1291	14	kay	kay	PROPN
admet-2043	1291	15	,	,	PUNCT
admet-2043	1291	16	r.a	r.a	PROPN
admet-2043	1291	17	.	.	PROPN
admet-2043	1291	18	nessler	nessler	PROPN
admet-2043	1291	19	,	,	PUNCT
admet-2043	1291	20	h.k	h.k	PROPN
admet-2043	1291	21	.	.	PROPN
admet-2043	1291	22	wilson	wilson	PROPN
admet-2043	1291	23	,	,	PUNCT
admet-2043	1291	24	a.	a.	PROPN
admet-2043	1291	25	al	al	PROPN
admet-2043	1291	26	-	-	PUNCT
admet-2043	1291	27	ahmad	ahmad	PROPN
admet-2043	1291	28	,	,	PUNCT
admet-2043	1291	29	s.p	s.p	PROPN
admet-2043	1291	30	.	.	PROPN
admet-2043	1291	31	palecek	palecek	PROPN
admet-2043	1291	32	,	,	PUNCT
admet-2043	1291	33	e.v	e.v	PROPN
admet-2043	1291	34	.	.	NOUN
admet-2043	1291	35	shusta	shusta	NOUN
admet-2043	1291	36	.	.	PUNCT
admet-2043	1292	1	derivation	derivation	NOUN
admet-2043	1292	2	of	of	ADP
admet-2043	1292	3	blood	blood	NOUN
admet-2043	1292	4	-	-	PUNCT
admet-2043	1292	5	brain	brain	NOUN
admet-2043	1292	6	barrier	barrier	NOUN
admet-2043	1292	7	endothelial	endothelial	NOUN
admet-2043	1292	8	cells	cell	NOUN
admet-2043	1292	9	from	from	ADP
admet-2043	1292	10	human	human	ADJ
admet-2043	1292	11	pluripotent	pluripotent	NOUN
admet-2043	1292	12	stem	stem	NOUN
admet-2043	1292	13	cells	cell	NOUN
admet-2043	1292	14	.	.	PUNCT
admet-2043	1293	1	nature	nature	NOUN
admet-2043	1293	2	biotechnology	biotechnology	NOUN
admet-2043	1293	3	30	30	NUM
admet-2043	1293	4	(	(	PUNCT
admet-2043	1293	5	2012	2012	NUM
admet-2043	1293	6	)	)	PUNCT
admet-2043	1293	7	783	783	NUM
admet-2043	1293	8	-	-	SYM
admet-2043	1293	9	791	791	NUM
admet-2043	1293	10	.	.	PUNCT
admet-2043	1294	1	https://doi.org/10.1038/nbt.2247	https://doi.org/10.1038/nbt.2247	NOUN
admet-2043	1294	2	.	.	PUNCT
admet-2043	1295	1	[	[	X
admet-2043	1295	2	137	137	NUM
admet-2043	1295	3	]	]	PUNCT
admet-2043	1295	4	a.	a.	NOUN
admet-2043	1295	5	patabendige	patabendige	NOUN
admet-2043	1295	6	,	,	PUNCT
admet-2043	1295	7	r.a	r.a	PROPN
admet-2043	1295	8	.	.	PROPN
admet-2043	1295	9	skinner	skinner	PROPN
admet-2043	1295	10	,	,	PUNCT
admet-2043	1295	11	n.j	n.j	PROPN
admet-2043	1295	12	.	.	PROPN
admet-2043	1295	13	abbott	abbott	PROPN
admet-2043	1295	14	.	.	PUNCT
admet-2043	1296	1	establishment	establishment	NOUN
admet-2043	1296	2	of	of	ADP
admet-2043	1296	3	a	a	DET
admet-2043	1296	4	simplified	simplified	ADJ
admet-2043	1296	5	in	in	ADP
admet-2043	1296	6	vitro	vitro	X
admet-2043	1296	7	porcine	porcine	NOUN
admet-2043	1296	8	bloodbrain	bloodbrain	NOUN
admet-2043	1296	9	barrier	barrier	NOUN
admet-2043	1296	10	model	model	NOUN
admet-2043	1296	11	with	with	ADP
admet-2043	1296	12	high	high	ADJ
admet-2043	1296	13	transendothelial	transendothelial	ADJ
admet-2043	1296	14	electrical	electrical	ADJ
admet-2043	1296	15	resistance	resistance	NOUN
admet-2043	1296	16	.	.	PUNCT
admet-2043	1297	1	brain	brain	NOUN
admet-2043	1297	2	research	research	NOUN
admet-2043	1297	3	1521	1521	NUM
admet-2043	1297	4	(	(	PUNCT
admet-2043	1297	5	2013	2013	NUM
admet-2043	1297	6	)	)	PUNCT
admet-2043	1297	7	115	115	NUM
admet-2043	1297	8	.	.	PUNCT
admet-2043	1298	1	https://doi.org/10.1016/j.brainres.2012.06.057	https://doi.org/10.1016/j.brainres.2012.06.057	NOUN
admet-2043	1298	2	.	.	PUNCT
admet-2043	1299	1	[	[	X
admet-2043	1299	2	138	138	NUM
admet-2043	1299	3	]	]	X
admet-2043	1299	4	ü.	ü.	NOUN
admet-2043	1299	5	langel	langel	NOUN
admet-2043	1299	6	,	,	PUNCT
admet-2043	1299	7	ü.	ü.	NOUN
admet-2043	1299	8	langel	langel	NOUN
admet-2043	1299	9	,	,	PUNCT
admet-2043	1299	10	classes	class	NOUN
admet-2043	1299	11	and	and	CCONJ
admet-2043	1299	12	applications	application	NOUN
admet-2043	1299	13	of	of	ADP
admet-2043	1299	14	cell	cell	NOUN
admet-2043	1299	15	-	-	PUNCT
admet-2043	1299	16	penetrating	penetrate	VERB
admet-2043	1299	17	peptides	peptide	NOUN
admet-2043	1299	18	,	,	PUNCT
admet-2043	1299	19	in	in	ADP
admet-2043	1299	20	cell	cell	NOUN
admet-2043	1299	21	-	-	PUNCT
admet-2043	1299	22	penetrating	penetrate	VERB
admet-2043	1299	23	peptides	peptide	NOUN
admet-2043	1299	24	,	,	PUNCT
admet-2043	1299	25	springer2019	springer2019	PROPN
admet-2043	1299	26	,	,	PUNCT
admet-2043	1299	27	p.	p.	NOUN
admet-2043	1299	28	29	29	NUM
admet-2043	1299	29	-	-	SYM
admet-2043	1299	30	82	82	NUM
admet-2043	1299	31	.	.	PUNCT
admet-2043	1300	1	https://doi.org/10.1007/978-981-13-8747-0	https://doi.org/10.1007/978-981-13-8747-0	X
admet-2043	1300	2	.	.	PUNCT
admet-2043	1301	1	[	[	X
admet-2043	1301	2	139	139	NUM
admet-2043	1301	3	]	]	X
admet-2043	1301	4	s.	s.	PROPN
admet-2043	1301	5	hanada	hanada	PROPN
admet-2043	1301	6	,	,	PUNCT
admet-2043	1301	7	k.	k.	PROPN
admet-2043	1301	8	fujioka	fujioka	PROPN
admet-2043	1301	9	,	,	PUNCT
admet-2043	1301	10	y.	y.	PROPN
admet-2043	1301	11	inoue	inoue	PROPN
admet-2043	1301	12	,	,	PUNCT
admet-2043	1301	13	f.	f.	PROPN
admet-2043	1301	14	kanaya	kanaya	PROPN
admet-2043	1301	15	,	,	PUNCT
admet-2043	1301	16	y.	y.	PROPN
admet-2043	1301	17	manome	manome	PROPN
admet-2043	1301	18	,	,	PUNCT
admet-2043	1301	19	k.	k.	PROPN
admet-2043	1301	20	yamamoto	yamamoto	PROPN
admet-2043	1301	21	.	.	PUNCT
admet-2043	1302	1	cell	cell	NOUN
admet-2043	1302	2	-	-	PUNCT
admet-2043	1302	3	based	base	VERB
admet-2043	1302	4	in	in	ADP
admet-2043	1302	5	vitro	vitro	X
admet-2043	1302	6	bloodbrain	bloodbrain	NOUN
admet-2043	1302	7	barrier	barrier	NOUN
admet-2043	1302	8	model	model	NOUN
admet-2043	1302	9	can	can	AUX
admet-2043	1302	10	rapidly	rapidly	ADV
admet-2043	1302	11	evaluate	evaluate	VERB
admet-2043	1302	12	nanoparticles	nanoparticle	NOUN
admet-2043	1302	13	'	'	PART
admet-2043	1302	14	brain	brain	NOUN
admet-2043	1302	15	permeability	permeability	NOUN
admet-2043	1302	16	in	in	ADP
admet-2043	1302	17	association	association	NOUN
admet-2043	1302	18	with	with	ADP
admet-2043	1302	19	particle	particle	NOUN
admet-2043	1302	20	size	size	NOUN
admet-2043	1302	21	and	and	CCONJ
admet-2043	1302	22	surface	surface	NOUN
admet-2043	1302	23	modification	modification	NOUN
admet-2043	1302	24	.	.	PUNCT
admet-2043	1303	1	international	international	ADJ
admet-2043	1303	2	journal	journal	NOUN
admet-2043	1303	3	of	of	ADP
admet-2043	1303	4	molecular	molecular	ADJ
admet-2043	1303	5	sciences	science	NOUN
admet-2043	1303	6	15	15	NUM
admet-2043	1303	7	(	(	PUNCT
admet-2043	1303	8	2014	2014	NUM
admet-2043	1303	9	)	)	PUNCT
admet-2043	1303	10	1812	1812	NUM
admet-2043	1303	11	-	-	SYM
admet-2043	1303	12	1825	1825	NUM
admet-2043	1303	13	.	.	PUNCT
admet-2043	1304	1	https://doi.org/10.3390/ijms15021812	https://doi.org/10.3390/ijms15021812	NOUN
admet-2043	1304	2	.	.	PUNCT
admet-2043	1305	1	[	[	X
admet-2043	1305	2	140	140	NUM
admet-2043	1305	3	]	]	PUNCT
admet-2043	1305	4	m.	m.	NOUN
admet-2043	1305	5	mirahmad	mirahmad	PROPN
admet-2043	1305	6	,	,	PUNCT
admet-2043	1305	7	r.	r.	PROPN
admet-2043	1305	8	sabourian	sabourian	PROPN
admet-2043	1305	9	,	,	PUNCT
admet-2043	1305	10	m.	m.	NOUN
admet-2043	1305	11	mahdavi	mahdavi	PROPN
admet-2043	1305	12	,	,	PUNCT
admet-2043	1305	13	b.	b.	PROPN
admet-2043	1305	14	larijani	larijani	PROPN
admet-2043	1305	15	,	,	PUNCT
admet-2043	1305	16	m.	m.	NOUN
admet-2043	1305	17	safavi	safavi	NOUN
admet-2043	1305	18	.	.	PUNCT
admet-2043	1306	1	in	in	ADP
admet-2043	1306	2	vitro	vitro	X
admet-2043	1306	3	cell	cell	NOUN
admet-2043	1306	4	-	-	PUNCT
admet-2043	1306	5	based	base	VERB
admet-2043	1306	6	models	model	NOUN
admet-2043	1306	7	of	of	ADP
admet-2043	1306	8	druginduced	druginduced	ADJ
admet-2043	1306	9	hepatotoxicity	hepatotoxicity	NOUN
admet-2043	1306	10	screening	screening	NOUN
admet-2043	1306	11	:	:	PUNCT
admet-2043	1306	12	progress	progress	NOUN
admet-2043	1306	13	and	and	CCONJ
admet-2043	1306	14	limitation	limitation	NOUN
admet-2043	1306	15	.	.	PUNCT
admet-2043	1307	1	drug	drug	NOUN
admet-2043	1307	2	metabolism	metabolism	NOUN
admet-2043	1307	3	reviews	review	NOUN
admet-2043	1307	4	54	54	NUM
admet-2043	1307	5	(	(	PUNCT
admet-2043	1307	6	2022	2022	NUM
admet-2043	1307	7	)	)	PUNCT
admet-2043	1307	8	161	161	NUM
admet-2043	1307	9	-	-	SYM
admet-2043	1307	10	193	193	NUM
admet-2043	1307	11	.	.	PUNCT
admet-2043	1308	1	https://doi.org/10.1080/03602532.2022.2064487	https://doi.org/10.1080/03602532.2022.2064487	PROPN
admet-2043	1308	2	.	.	PUNCT
admet-2043	1309	1	[	[	X
admet-2043	1309	2	141	141	NUM
admet-2043	1309	3	]	]	X
admet-2043	1309	4	m.a	m.a	PROPN
admet-2043	1309	5	.	.	PROPN
admet-2043	1309	6	kaisar	kaisar	PROPN
admet-2043	1309	7	,	,	PUNCT
admet-2043	1309	8	r.k	r.k	PROPN
admet-2043	1309	9	.	.	PROPN
admet-2043	1309	10	sajja	sajja	PROPN
admet-2043	1309	11	,	,	PUNCT
admet-2043	1309	12	s.	s.	PROPN
admet-2043	1309	13	prasad	prasad	PROPN
admet-2043	1309	14	,	,	PUNCT
admet-2043	1309	15	v.v	v.v	PROPN
admet-2043	1309	16	.	.	PROPN
admet-2043	1309	17	abhyankar	abhyankar	PROPN
admet-2043	1309	18	,	,	PUNCT
admet-2043	1309	19	t.	t.	PROPN
admet-2043	1309	20	liles	liles	PROPN
admet-2043	1309	21	,	,	PUNCT
admet-2043	1309	22	l.	l.	PROPN
admet-2043	1309	23	cucullo	cucullo	PROPN
admet-2043	1309	24	.	.	PUNCT
admet-2043	1310	1	new	new	ADJ
admet-2043	1310	2	experimental	experimental	ADJ
admet-2043	1310	3	models	model	NOUN
admet-2043	1310	4	of	of	ADP
admet-2043	1310	5	the	the	DET
admet-2043	1310	6	blood	blood	NOUN
admet-2043	1310	7	-	-	PUNCT
admet-2043	1310	8	brain	brain	NOUN
admet-2043	1310	9	barrier	barrier	NOUN
admet-2043	1310	10	for	for	ADP
admet-2043	1310	11	cns	cns	NOUN
admet-2043	1310	12	drug	drug	NOUN
admet-2043	1310	13	discovery	discovery	NOUN
admet-2043	1310	14	.	.	PUNCT
admet-2043	1311	1	expert	expert	ADJ
admet-2043	1311	2	opinion	opinion	NOUN
admet-2043	1311	3	on	on	ADP
admet-2043	1311	4	drug	drug	NOUN
admet-2043	1311	5	discovery	discovery	NOUN
admet-2043	1311	6	12	12	NUM
admet-2043	1311	7	(	(	PUNCT
admet-2043	1311	8	2017	2017	NUM
admet-2043	1311	9	)	)	PUNCT
admet-2043	1311	10	89103	89103	NUM
admet-2043	1311	11	.	.	PUNCT
admet-2043	1312	1	https://doi.org/10.1080/17460441.2017.1253676	https://doi.org/10.1080/17460441.2017.1253676	X
admet-2043	1312	2	.	.	PUNCT
admet-2043	1313	1	[	[	X
admet-2043	1313	2	142	142	NUM
admet-2043	1313	3	]	]	PUNCT
admet-2043	1313	4	f.	f.	PROPN
admet-2043	1313	5	sivandzade	sivandzade	PROPN
admet-2043	1313	6	,	,	PUNCT
admet-2043	1313	7	l.	l.	PROPN
admet-2043	1313	8	cucullo	cucullo	PROPN
admet-2043	1313	9	.	.	PUNCT
admet-2043	1314	1	in	in	ADP
admet-2043	1314	2	-	-	PUNCT
admet-2043	1314	3	vitro	vitro	X
admet-2043	1314	4	blood	blood	NOUN
admet-2043	1314	5	-	-	PUNCT
admet-2043	1314	6	brain	brain	NOUN
admet-2043	1314	7	barrier	barrier	NOUN
admet-2043	1314	8	modeling	modeling	NOUN
admet-2043	1314	9	:	:	PUNCT
admet-2043	1314	10	a	a	DET
admet-2043	1314	11	review	review	NOUN
admet-2043	1314	12	of	of	ADP
admet-2043	1314	13	modern	modern	ADJ
admet-2043	1314	14	and	and	CCONJ
admet-2043	1314	15	fastadvancing	fastadvance	VERB
admet-2043	1314	16	technologies	technology	NOUN
admet-2043	1314	17	.	.	PUNCT
admet-2043	1315	1	journal	journal	NOUN
admet-2043	1315	2	of	of	ADP
admet-2043	1315	3	cerebral	cerebral	ADJ
admet-2043	1315	4	blood	blood	NOUN
admet-2043	1315	5	flow	flow	NOUN
admet-2043	1315	6	and	and	CCONJ
admet-2043	1315	7	metabolism	metabolism	NOUN
admet-2043	1315	8	38	38	NUM
admet-2043	1315	9	(	(	PUNCT
admet-2043	1315	10	2018	2018	NUM
admet-2043	1315	11	)	)	PUNCT
admet-2043	1315	12	1667	1667	NUM
admet-2043	1315	13	-	-	SYM
admet-2043	1315	14	1681	1681	NUM
admet-2043	1315	15	.	.	PUNCT
admet-2043	1316	1	https://doi.org/10.1177/0271678x18788769	https://doi.org/10.1177/0271678x18788769	NOUN
admet-2043	1316	2	.	.	PUNCT
admet-2043	1317	1	[	[	X
admet-2043	1317	2	143	143	NUM
admet-2043	1317	3	]	]	X
admet-2043	1317	4	d.	d.	PROPN
admet-2043	1317	5	huh	huh	PROPN
admet-2043	1317	6	,	,	PUNCT
admet-2043	1317	7	g.a	g.a	PROPN
admet-2043	1317	8	.	.	PROPN
admet-2043	1317	9	hamilton	hamilton	PROPN
admet-2043	1317	10	,	,	PUNCT
admet-2043	1317	11	d.e	d.e	PROPN
admet-2043	1317	12	.	.	PROPN
admet-2043	1317	13	ingber	ingber	PROPN
admet-2043	1317	14	.	.	PUNCT
admet-2043	1318	1	from	from	ADP
admet-2043	1318	2	3d	3d	NUM
admet-2043	1318	3	cell	cell	NOUN
admet-2043	1318	4	culture	culture	NOUN
admet-2043	1318	5	to	to	ADP
admet-2043	1318	6	organs	organ	NOUN
admet-2043	1318	7	-	-	PUNCT
admet-2043	1318	8	on	on	ADP
admet-2043	1318	9	-	-	PUNCT
admet-2043	1318	10	chips	chip	NOUN
admet-2043	1318	11	.	.	PUNCT
admet-2043	1319	1	trends	trend	NOUN
admet-2043	1319	2	in	in	ADP
admet-2043	1319	3	cell	cell	NOUN
admet-2043	1319	4	biology	biology	NOUN
admet-2043	1319	5	21	21	NUM
admet-2043	1319	6	(	(	PUNCT
admet-2043	1319	7	2011	2011	NUM
admet-2043	1319	8	)	)	PUNCT
admet-2043	1319	9	745	745	NUM
admet-2043	1319	10	-	-	SYM
admet-2043	1319	11	754	754	NUM
admet-2043	1319	12	.	.	PUNCT
admet-2043	1320	1	https://doi.org/10.1016/j.tcb.2011.09.005	https://doi.org/10.1016/j.tcb.2011.09.005	VERB
admet-2043	1320	2	.	.	PUNCT
admet-2043	1321	1	https://doi.org/10.1016/j.biomaterials.2015.02.083	https://doi.org/10.1016/j.biomaterials.2015.02.083	PROPN
admet-2043	1321	2	https://doi.org/10.2147/ijn.s35832	https://doi.org/10.2147/ijn.s35832	NUM
admet-2043	1321	3	https://doi.org/10.1002/adfm.201705479	https://doi.org/10.1002/adfm.201705479	VERB
admet-2043	1321	4	https://doi.org/10.1083/jcb.115.6.1725	https://doi.org/10.1083/jcb.115.6.1725	PRON
admet-2043	1321	5	https://doi.org/10.1007/s11095-013-1156-7	https://doi.org/10.1007/s11095-013-1156-7	NUM
admet-2043	1321	6	https://doi.org/10.1021/nn5018523	https://doi.org/10.1021/nn5018523	NOUN
admet-2043	1321	7	https://doi.org/10.1602/neurorx.2.1.3	https://doi.org/10.1602/neurorx.2.1.3	NOUN
admet-2043	1321	8	https://doi.org/10.1016/j.nano.2011.05.016	https://doi.org/10.1016/j.nano.2011.05.016	PROPN
admet-2043	1321	9	https://doi.org/10.1016/j.ejpb.2014.03.012	https://doi.org/10.1016/j.ejpb.2014.03.012	PRON
admet-2043	1321	10	https://doi.org/10.1038/nbt.2247	https://doi.org/10.1038/nbt.2247	NOUN
admet-2043	1321	11	https://doi.org/10.1016/j.brainres.2012.06.057	https://doi.org/10.1016/j.brainres.2012.06.057	NOUN
admet-2043	1321	12	https://doi.org/10.1007/978-981-13-8747-0	https://doi.org/10.1007/978-981-13-8747-0	ADV
admet-2043	1321	13	https://doi.org/10.3390/ijms15021812	https://doi.org/10.3390/ijms15021812	NOUN
admet-2043	1321	14	https://doi.org/10.1080/03602532.2022.2064487	https://doi.org/10.1080/03602532.2022.2064487	PROPN
admet-2043	1322	1	https://doi.org/10.1080/17460441.2017.1253676	https://doi.org/10.1080/17460441.2017.1253676	PROPN
admet-2043	1323	1	https://doi.org/10.1177/0271678x18788769	https://doi.org/10.1177/0271678x18788769	NOUN
admet-2043	1323	2	https://doi.org/10.1016/j.tcb.2011.09.005	https://doi.org/10.1016/j.tcb.2011.09.005	PROPN
admet-2043	1323	3	admet	admet	PROPN
admet-2043	1323	4	&	&	CCONJ
admet-2043	1323	5	dmpk	dmpk	PROPN
admet-2043	1323	6	12(1	12(1	PROPN
admet-2043	1323	7	)	)	PUNCT
admet-2043	1323	8	(	(	PUNCT
admet-2043	1323	9	2024	2024	NUM
admet-2043	1323	10	)	)	PUNCT
admet-2043	1323	11	63	63	NUM
admet-2043	1323	12	-	-	SYM
admet-2043	1323	13	105	105	NUM
admet-2043	1323	14	nanomaterials	nanomaterial	NOUN
admet-2043	1323	15	as	as	ADP
admet-2043	1323	16	drug	drug	NOUN
admet-2043	1323	17	delivery	delivery	NOUN
admet-2043	1323	18	agents	agent	NOUN
admet-2043	1323	19	for	for	ADP
admet-2043	1323	20	overcoming	overcome	VERB
admet-2043	1323	21	bbb	bbb	PROPN
admet-2043	1323	22	doi	doi	NOUN
admet-2043	1323	23	:	:	PUNCT
admet-2043	1323	24	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1323	25	101	101	NUM
admet-2043	1323	26	[	[	X
admet-2043	1323	27	144	144	NUM
admet-2043	1323	28	]	]	X
admet-2043	1323	29	r.	r.	PROPN
admet-2043	1323	30	cecchelli	cecchelli	PROPN
admet-2043	1323	31	,	,	PUNCT
admet-2043	1323	32	b.	b.	PROPN
admet-2043	1323	33	dehouck	dehouck	PROPN
admet-2043	1323	34	,	,	PUNCT
admet-2043	1323	35	l.	l.	PROPN
admet-2043	1323	36	descamps	descamps	PROPN
admet-2043	1323	37	,	,	PUNCT
admet-2043	1323	38	l.	l.	PROPN
admet-2043	1323	39	fenart	fenart	PROPN
admet-2043	1323	40	,	,	PUNCT
admet-2043	1323	41	v.v	v.v	PROPN
admet-2043	1323	42	.	.	PROPN
admet-2043	1323	43	buee	buee	NOUN
admet-2043	1323	44	-	-	PUNCT
admet-2043	1323	45	scherrer	scherrer	NOUN
admet-2043	1323	46	,	,	PUNCT
admet-2043	1323	47	c.	c.	PROPN
admet-2043	1323	48	duhem	duhem	PROPN
admet-2043	1323	49	,	,	PUNCT
admet-2043	1323	50	s.	s.	PROPN
admet-2043	1323	51	lundquist	lundquist	PROPN
admet-2043	1323	52	,	,	PUNCT
admet-2043	1323	53	m.	m.	NOUN
admet-2043	1323	54	rentfel	rentfel	NOUN
admet-2043	1323	55	,	,	PUNCT
admet-2043	1323	56	g.	g.	PROPN
admet-2043	1323	57	torpier	torpier	NOUN
admet-2043	1323	58	,	,	PUNCT
admet-2043	1323	59	m.p	m.p	PROPN
admet-2043	1323	60	.	.	PROPN
admet-2043	1323	61	dehouck	dehouck	PROPN
admet-2043	1323	62	.	.	PUNCT
admet-2043	1324	1	in	in	ADP
admet-2043	1324	2	vitro	vitro	X
admet-2043	1324	3	model	model	NOUN
admet-2043	1324	4	for	for	ADP
admet-2043	1324	5	evaluating	evaluate	VERB
admet-2043	1324	6	drug	drug	NOUN
admet-2043	1324	7	transport	transport	NOUN
admet-2043	1324	8	across	across	ADP
admet-2043	1324	9	the	the	DET
admet-2043	1324	10	bloodbrain	bloodbrain	NOUN
admet-2043	1324	11	barrier	barrier	NOUN
admet-2043	1324	12	.	.	PUNCT
admet-2043	1325	1	advanced	advanced	ADJ
admet-2043	1325	2	drug	drug	NOUN
admet-2043	1325	3	delivery	delivery	NOUN
admet-2043	1325	4	reviews	review	VERB
admet-2043	1325	5	36	36	NUM
admet-2043	1325	6	(	(	PUNCT
admet-2043	1325	7	1999	1999	NUM
admet-2043	1325	8	)	)	PUNCT
admet-2043	1325	9	165	165	NUM
admet-2043	1325	10	-	-	SYM
admet-2043	1325	11	178	178	NUM
admet-2043	1325	12	.	.	PUNCT
admet-2043	1326	1	https://doi.org/10.1016/s0169409x(98)00083-0	https://doi.org/10.1016/s0169409x(98)00083-0	ADV
admet-2043	1326	2	.	.	PUNCT
admet-2043	1327	1	[	[	X
admet-2043	1327	2	145	145	NUM
admet-2043	1327	3	]	]	PUNCT
admet-2043	1327	4	f.	f.	PROPN
admet-2043	1327	5	baaijens	baaijens	PROPN
admet-2043	1327	6	,	,	PUNCT
admet-2043	1327	7	c.	c.	PROPN
admet-2043	1327	8	bouten	bouten	NOUN
admet-2043	1327	9	,	,	PUNCT
admet-2043	1327	10	n.	n.	PROPN
admet-2043	1327	11	driessen	driessen	PROPN
admet-2043	1327	12	.	.	PUNCT
admet-2043	1328	1	modeling	model	VERB
admet-2043	1328	2	collagen	collagen	NOUN
admet-2043	1328	3	remodeling	remodeling	NOUN
admet-2043	1328	4	.	.	PUNCT
admet-2043	1329	1	journal	journal	NOUN
admet-2043	1329	2	of	of	ADP
admet-2043	1329	3	biomechanics	biomechanic	NOUN
admet-2043	1329	4	43	43	NUM
admet-2043	1329	5	(	(	PUNCT
admet-2043	1329	6	2010	2010	NUM
admet-2043	1329	7	)	)	PUNCT
admet-2043	1329	8	166	166	NUM
admet-2043	1329	9	-	-	SYM
admet-2043	1329	10	175	175	NUM
admet-2043	1329	11	.	.	PUNCT
admet-2043	1330	1	https://doi.org/10.1016/j.jbiomech.2009.09.022	https://doi.org/10.1016/j.jbiomech.2009.09.022	PROPN
admet-2043	1330	2	.	.	PUNCT
admet-2043	1331	1	[	[	X
admet-2043	1331	2	146	146	NUM
admet-2043	1331	3	]	]	X
admet-2043	1331	4	y.	y.	PROPN
admet-2043	1331	5	yan	yan	PROPN
admet-2043	1331	6	,	,	PUNCT
admet-2043	1331	7	y.	y.	PROPN
admet-2043	1331	8	chen	chen	PROPN
admet-2043	1331	9	,	,	PUNCT
admet-2043	1331	10	z.	z.	PROPN
admet-2043	1331	11	liu	liu	PROPN
admet-2043	1331	12	,	,	PUNCT
admet-2043	1331	13	f.	f.	PROPN
admet-2043	1331	14	cai	cai	PROPN
admet-2043	1331	15	,	,	PUNCT
admet-2043	1331	16	w.	w.	PROPN
admet-2043	1331	17	niu	niu	PROPN
admet-2043	1331	18	,	,	PUNCT
admet-2043	1331	19	l.	l.	PROPN
admet-2043	1331	20	song	song	PROPN
admet-2043	1331	21	,	,	PUNCT
admet-2043	1331	22	h.	h.	PROPN
admet-2043	1331	23	liang	liang	PROPN
admet-2043	1331	24	,	,	PUNCT
admet-2043	1331	25	z.	z.	PROPN
admet-2043	1331	26	su	su	PROPN
admet-2043	1331	27	,	,	PUNCT
admet-2043	1331	28	b.	b.	PROPN
admet-2043	1331	29	yu	yu	PROPN
admet-2043	1331	30	,	,	PUNCT
admet-2043	1331	31	f.	f.	PROPN
admet-2043	1331	32	yan	yan	PROPN
admet-2043	1331	33	.	.	PUNCT
admet-2043	1332	1	brain	brain	NOUN
admet-2043	1332	2	delivery	delivery	NOUN
admet-2043	1332	3	of	of	ADP
admet-2043	1332	4	curcumin	curcumin	NOUN
admet-2043	1332	5	through	through	ADP
admet-2043	1332	6	low	low	ADJ
admet-2043	1332	7	-	-	PUNCT
admet-2043	1332	8	intensity	intensity	NOUN
admet-2043	1332	9	ultrasound	ultrasound	NOUN
admet-2043	1332	10	-	-	PUNCT
admet-2043	1332	11	induced	induce	VERB
admet-2043	1332	12	blood	blood	NOUN
admet-2043	1332	13	-	-	PUNCT
admet-2043	1332	14	brain	brain	NOUN
admet-2043	1332	15	barrier	barrier	NOUN
admet-2043	1332	16	opening	opening	NOUN
admet-2043	1332	17	via	via	ADP
admet-2043	1332	18	lipid	lipid	NOUN
admet-2043	1332	19	-	-	PUNCT
admet-2043	1332	20	plga	plga	NOUN
admet-2043	1332	21	nanobubbles	nanobubble	NOUN
admet-2043	1332	22	.	.	PUNCT
admet-2043	1333	1	international	international	ADJ
admet-2043	1333	2	journal	journal	PROPN
admet-2043	1333	3	of	of	ADP
admet-2043	1333	4	nanomedicine	nanomedicine	NOUN
admet-2043	1333	5	16	16	NUM
admet-2043	1333	6	(	(	PUNCT
admet-2043	1333	7	2021	2021	NUM
admet-2043	1333	8	)	)	PUNCT
admet-2043	1333	9	7433	7433	NUM
admet-2043	1333	10	-	-	SYM
admet-2043	1333	11	7447	7447	NUM
admet-2043	1333	12	.	.	PUNCT
admet-2043	1334	1	https://doi.org/10.2147/ijn.s327737	https://doi.org/10.2147/ijn.s327737	NOUN
admet-2043	1334	2	.	.	PUNCT
admet-2043	1335	1	[	[	X
admet-2043	1335	2	147	147	NUM
admet-2043	1335	3	]	]	X
admet-2043	1335	4	h.c	h.c	PROPN
admet-2043	1335	5	.	.	PROPN
admet-2043	1335	6	helms	helms	PROPN
admet-2043	1335	7	,	,	PUNCT
admet-2043	1335	8	n.j	n.j	PROPN
admet-2043	1335	9	.	.	PROPN
admet-2043	1335	10	abbott	abbott	PROPN
admet-2043	1335	11	,	,	PUNCT
admet-2043	1335	12	m.	m.	NOUN
admet-2043	1335	13	burek	burek	PROPN
admet-2043	1335	14	,	,	PUNCT
admet-2043	1335	15	r.	r.	PROPN
admet-2043	1335	16	cecchelli	cecchelli	PROPN
admet-2043	1335	17	,	,	PUNCT
admet-2043	1335	18	p.o	p.o	PROPN
admet-2043	1335	19	.	.	PROPN
admet-2043	1335	20	couraud	couraud	PROPN
admet-2043	1335	21	,	,	PUNCT
admet-2043	1335	22	m.a	m.a	PROPN
admet-2043	1335	23	.	.	PROPN
admet-2043	1335	24	deli	deli	PROPN
admet-2043	1335	25	,	,	PUNCT
admet-2043	1335	26	c.	c.	PROPN
admet-2043	1335	27	forster	forster	PROPN
admet-2043	1335	28	,	,	PUNCT
admet-2043	1335	29	h.j	h.j	PROPN
admet-2043	1335	30	.	.	PROPN
admet-2043	1335	31	galla	galla	PROPN
admet-2043	1335	32	,	,	PUNCT
admet-2043	1335	33	i.a	i.a	PROPN
admet-2043	1335	34	.	.	PROPN
admet-2043	1335	35	romero	romero	PROPN
admet-2043	1335	36	,	,	PUNCT
admet-2043	1335	37	e.v	e.v	PROPN
admet-2043	1335	38	.	.	PROPN
admet-2043	1335	39	shusta	shusta	PROPN
admet-2043	1335	40	,	,	PUNCT
admet-2043	1335	41	m.j	m.j	PROPN
admet-2043	1335	42	.	.	PROPN
admet-2043	1335	43	stebbins	stebbins	PROPN
admet-2043	1335	44	,	,	PUNCT
admet-2043	1335	45	e.	e.	PROPN
admet-2043	1335	46	vandenhaute	vandenhaute	PROPN
admet-2043	1335	47	,	,	PUNCT
admet-2043	1335	48	b.	b.	PROPN
admet-2043	1335	49	weksler	weksler	PROPN
admet-2043	1335	50	,	,	PUNCT
admet-2043	1335	51	b.	b.	PROPN
admet-2043	1335	52	brodin	brodin	PROPN
admet-2043	1335	53	.	.	PUNCT
admet-2043	1336	1	in	in	ADP
admet-2043	1336	2	vitro	vitro	X
admet-2043	1336	3	models	model	NOUN
admet-2043	1336	4	of	of	ADP
admet-2043	1336	5	the	the	DET
admet-2043	1336	6	blood	blood	NOUN
admet-2043	1336	7	-	-	PUNCT
admet-2043	1336	8	brain	brain	NOUN
admet-2043	1336	9	barrier	barrier	NOUN
admet-2043	1336	10	:	:	PUNCT
admet-2043	1336	11	an	an	DET
admet-2043	1336	12	overview	overview	NOUN
admet-2043	1336	13	of	of	ADP
admet-2043	1336	14	commonly	commonly	ADV
admet-2043	1336	15	used	use	VERB
admet-2043	1336	16	brain	brain	NOUN
admet-2043	1336	17	endothelial	endothelial	ADJ
admet-2043	1336	18	cell	cell	NOUN
admet-2043	1336	19	culture	culture	NOUN
admet-2043	1336	20	models	model	NOUN
admet-2043	1336	21	and	and	CCONJ
admet-2043	1336	22	guidelines	guideline	NOUN
admet-2043	1336	23	for	for	ADP
admet-2043	1336	24	their	their	PRON
admet-2043	1336	25	use	use	NOUN
admet-2043	1336	26	.	.	PUNCT
admet-2043	1337	1	journal	journal	NOUN
admet-2043	1337	2	of	of	ADP
admet-2043	1337	3	cerebral	cerebral	ADJ
admet-2043	1337	4	blood	blood	NOUN
admet-2043	1337	5	flow	flow	NOUN
admet-2043	1337	6	and	and	CCONJ
admet-2043	1337	7	metabolism	metabolism	NOUN
admet-2043	1337	8	36	36	NUM
admet-2043	1337	9	(	(	PUNCT
admet-2043	1337	10	2016	2016	NUM
admet-2043	1337	11	)	)	PUNCT
admet-2043	1337	12	862	862	NUM
admet-2043	1337	13	-	-	SYM
admet-2043	1337	14	890	890	NUM
admet-2043	1337	15	.	.	PUNCT
admet-2043	1338	1	https://doi.org/10.1177/0271678x16630991	https://doi.org/10.1177/0271678x16630991	NOUN
admet-2043	1338	2	.	.	PUNCT
admet-2043	1339	1	[	[	X
admet-2043	1339	2	148	148	NUM
admet-2043	1339	3	]	]	PUNCT
admet-2043	1339	4	y.	y.	PROPN
admet-2043	1339	5	shin	shin	PROPN
admet-2043	1339	6	,	,	PUNCT
admet-2043	1339	7	s.	s.	PROPN
admet-2043	1339	8	han	han	PROPN
admet-2043	1339	9	,	,	PUNCT
admet-2043	1339	10	j.s	j.s	PROPN
admet-2043	1339	11	.	.	PROPN
admet-2043	1339	12	jeon	jeon	PROPN
admet-2043	1339	13	,	,	PUNCT
admet-2043	1339	14	k.	k.	PROPN
admet-2043	1339	15	yamamoto	yamamoto	PROPN
admet-2043	1339	16	,	,	PUNCT
admet-2043	1339	17	i.k	i.k	PROPN
admet-2043	1339	18	.	.	PROPN
admet-2043	1339	19	zervantonakis	zervantonakis	PROPN
admet-2043	1339	20	,	,	PUNCT
admet-2043	1339	21	r.	r.	PROPN
admet-2043	1339	22	sudo	sudo	PROPN
admet-2043	1339	23	,	,	PUNCT
admet-2043	1339	24	r.d	r.d	PROPN
admet-2043	1339	25	.	.	PROPN
admet-2043	1339	26	kamm	kamm	PROPN
admet-2043	1339	27	,	,	PUNCT
admet-2043	1339	28	s.	s.	PROPN
admet-2043	1339	29	chung	chung	PROPN
admet-2043	1339	30	.	.	PUNCT
admet-2043	1340	1	microfluidic	microfluidic	ADJ
admet-2043	1340	2	assay	assay	VERB
admet-2043	1340	3	for	for	ADP
admet-2043	1340	4	simultaneous	simultaneous	ADJ
admet-2043	1340	5	culture	culture	NOUN
admet-2043	1340	6	of	of	ADP
admet-2043	1340	7	multiple	multiple	ADJ
admet-2043	1340	8	cell	cell	NOUN
admet-2043	1340	9	types	type	NOUN
admet-2043	1340	10	on	on	ADP
admet-2043	1340	11	surfaces	surface	NOUN
admet-2043	1340	12	or	or	CCONJ
admet-2043	1340	13	within	within	ADP
admet-2043	1340	14	hydrogels	hydrogel	NOUN
admet-2043	1340	15	.	.	PUNCT
admet-2043	1341	1	nature	nature	NOUN
admet-2043	1341	2	protocols	protocol	NOUN
admet-2043	1341	3	7	7	NUM
admet-2043	1341	4	(	(	PUNCT
admet-2043	1341	5	2012	2012	NUM
admet-2043	1341	6	)	)	PUNCT
admet-2043	1341	7	1247	1247	NUM
admet-2043	1341	8	-	-	SYM
admet-2043	1341	9	1259	1259	NUM
admet-2043	1341	10	.	.	PUNCT
admet-2043	1342	1	https://doi.org/10.1038%2fnprot.2012.051	https://doi.org/10.1038%2fnprot.2012.051	NOUN
admet-2043	1342	2	.	.	PUNCT
admet-2043	1343	1	[	[	X
admet-2043	1343	2	149	149	NUM
admet-2043	1343	3	]	]	X
admet-2043	1343	4	t.d	t.d	PROPN
admet-2043	1343	5	.	.	PROPN
admet-2043	1343	6	brown	brown	PROPN
admet-2043	1343	7	,	,	PUNCT
admet-2043	1343	8	m.	m.	PROPN
admet-2043	1343	9	nowak	nowak	PROPN
admet-2043	1343	10	,	,	PUNCT
admet-2043	1343	11	a.v	a.v	PROPN
admet-2043	1343	12	.	.	PROPN
admet-2043	1343	13	bayles	bayle	NOUN
admet-2043	1343	14	,	,	PUNCT
admet-2043	1343	15	b.	b.	PROPN
admet-2043	1343	16	prabhakarpandian	prabhakarpandian	PROPN
admet-2043	1343	17	,	,	PUNCT
admet-2043	1343	18	p.	p.	PROPN
admet-2043	1343	19	karande	karande	PROPN
admet-2043	1343	20	,	,	PUNCT
admet-2043	1343	21	j.	j.	PROPN
admet-2043	1343	22	lahann	lahann	PROPN
admet-2043	1343	23	,	,	PUNCT
admet-2043	1343	24	m.e	m.e	PROPN
admet-2043	1343	25	.	.	PROPN
admet-2043	1343	26	helgeson	helgeson	PROPN
admet-2043	1343	27	,	,	PUNCT
admet-2043	1343	28	s.	s.	PROPN
admet-2043	1343	29	mitragotri	mitragotri	PROPN
admet-2043	1343	30	.	.	PUNCT
admet-2043	1344	1	a	a	DET
admet-2043	1344	2	microfluidic	microfluidic	ADJ
admet-2043	1344	3	model	model	NOUN
admet-2043	1344	4	of	of	ADP
admet-2043	1344	5	human	human	ADJ
admet-2043	1344	6	brain	brain	NOUN
admet-2043	1344	7	(	(	PUNCT
admet-2043	1344	8	muhub	muhub	NOUN
admet-2043	1344	9	)	)	PUNCT
admet-2043	1344	10	for	for	ADP
admet-2043	1344	11	assessment	assessment	NOUN
admet-2043	1344	12	of	of	ADP
admet-2043	1344	13	blood	blood	NOUN
admet-2043	1344	14	brain	brain	NOUN
admet-2043	1344	15	barrier	barrier	NOUN
admet-2043	1344	16	.	.	PUNCT
admet-2043	1345	1	bioengineering	bioengineering	NOUN
admet-2043	1345	2	&	&	CCONJ
admet-2043	1345	3	translational	translational	ADJ
admet-2043	1345	4	medicine	medicine	NOUN
admet-2043	1345	5	4	4	NUM
admet-2043	1345	6	(	(	PUNCT
admet-2043	1345	7	2019	2019	NUM
admet-2043	1345	8	)	)	PUNCT
admet-2043	1345	9	e10126	e10126	PROPN
admet-2043	1345	10	.	.	PUNCT
admet-2043	1345	11	https://doi.org/10.1002/btm2.10126	https://doi.org/10.1002/btm2.10126	PROPN
admet-2043	1345	12	.	.	PUNCT
admet-2043	1346	1	[	[	X
admet-2043	1346	2	150	150	NUM
admet-2043	1346	3	]	]	SYM
admet-2043	1346	4	n.j	n.j	PROPN
admet-2043	1346	5	.	.	PROPN
admet-2043	1346	6	abbott	abbott	PROPN
admet-2043	1346	7	.	.	PUNCT
admet-2043	1346	8	blood	blood	NOUN
admet-2043	1346	9	-	-	PUNCT
admet-2043	1346	10	brain	brain	NOUN
admet-2043	1346	11	barrier	barrier	NOUN
admet-2043	1346	12	structure	structure	NOUN
admet-2043	1346	13	and	and	CCONJ
admet-2043	1346	14	function	function	NOUN
admet-2043	1346	15	and	and	CCONJ
admet-2043	1346	16	the	the	DET
admet-2043	1346	17	challenges	challenge	NOUN
admet-2043	1346	18	for	for	ADP
admet-2043	1346	19	cns	cns	NOUN
admet-2043	1346	20	drug	drug	NOUN
admet-2043	1346	21	delivery	delivery	NOUN
admet-2043	1346	22	.	.	PUNCT
admet-2043	1347	1	journal	journal	NOUN
admet-2043	1347	2	of	of	ADP
admet-2043	1347	3	inherited	inherit	VERB
admet-2043	1347	4	metabolic	metabolic	NOUN
admet-2043	1347	5	disease	disease	NOUN
admet-2043	1347	6	36	36	NUM
admet-2043	1347	7	(	(	PUNCT
admet-2043	1347	8	2013	2013	NUM
admet-2043	1347	9	)	)	PUNCT
admet-2043	1347	10	437	437	NUM
admet-2043	1347	11	-	-	SYM
admet-2043	1347	12	449	449	NUM
admet-2043	1347	13	.	.	PUNCT
admet-2043	1348	1	https://doi.org/10.1007/s10545-0139608-0	https://doi.org/10.1007/s10545-0139608-0	NOUN
admet-2043	1348	2	.	.	PUNCT
admet-2043	1349	1	[	[	X
admet-2043	1349	2	151	151	NUM
admet-2043	1349	3	]	]	SYM
admet-2043	1349	4	m.b	m.b	PROPN
admet-2043	1349	5	.	.	PROPN
admet-2043	1349	6	esch	esch	PROPN
admet-2043	1349	7	,	,	PUNCT
admet-2043	1349	8	j.h	j.h	PROPN
admet-2043	1349	9	.	.	PROPN
admet-2043	1349	10	sung	sung	PROPN
admet-2043	1349	11	,	,	PUNCT
admet-2043	1349	12	j.	j.	PROPN
admet-2043	1349	13	yang	yang	PROPN
admet-2043	1349	14	,	,	PUNCT
admet-2043	1349	15	c.	c.	PROPN
admet-2043	1349	16	yu	yu	PROPN
admet-2043	1349	17	,	,	PUNCT
admet-2043	1349	18	j.	j.	PROPN
admet-2043	1349	19	yu	yu	PROPN
admet-2043	1349	20	,	,	PUNCT
admet-2043	1349	21	j.c	j.c	PROPN
admet-2043	1349	22	.	.	PROPN
admet-2043	1349	23	march	march	PROPN
admet-2043	1349	24	,	,	PUNCT
admet-2043	1349	25	m.l	m.l	PROPN
admet-2043	1349	26	.	.	PUNCT
admet-2043	1349	27	shuler	shuler	PROPN
admet-2043	1349	28	.	.	PUNCT
admet-2043	1350	1	on	on	ADP
admet-2043	1350	2	chip	chip	NOUN
admet-2043	1350	3	porous	porous	ADJ
admet-2043	1350	4	polymer	polymer	NOUN
admet-2043	1350	5	membranes	membrane	NOUN
admet-2043	1350	6	for	for	ADP
admet-2043	1350	7	integration	integration	NOUN
admet-2043	1350	8	of	of	ADP
admet-2043	1350	9	gastrointestinal	gastrointestinal	ADJ
admet-2043	1350	10	tract	tract	NOUN
admet-2043	1350	11	epithelium	epithelium	NOUN
admet-2043	1350	12	with	with	ADP
admet-2043	1350	13	microfluidic	microfluidic	ADJ
admet-2043	1350	14	'	'	PUNCT
admet-2043	1350	15	body	body	NOUN
admet-2043	1350	16	-	-	PUNCT
admet-2043	1350	17	on	on	ADP
admet-2043	1350	18	-	-	PUNCT
admet-2043	1350	19	a	a	DET
admet-2043	1350	20	-	-	PUNCT
admet-2043	1350	21	chip	chip	NOUN
admet-2043	1350	22	'	'	PUNCT
admet-2043	1350	23	devices	device	NOUN
admet-2043	1350	24	.	.	PUNCT
admet-2043	1351	1	biomedical	biomedical	ADJ
admet-2043	1351	2	microdevices	microdevice	NOUN
admet-2043	1351	3	14	14	NUM
admet-2043	1351	4	(	(	PUNCT
admet-2043	1351	5	2012	2012	NUM
admet-2043	1351	6	)	)	PUNCT
admet-2043	1351	7	895	895	NUM
admet-2043	1351	8	-	-	SYM
admet-2043	1351	9	906	906	NUM
admet-2043	1351	10	.	.	PUNCT
admet-2043	1352	1	https://doi.org/10.1007/s10544-012-9669-0	https://doi.org/10.1007/s10544-012-9669-0	NUM
admet-2043	1352	2	.	.	PUNCT
admet-2043	1353	1	[	[	X
admet-2043	1353	2	152	152	NUM
admet-2043	1353	3	]	]	X
admet-2043	1353	4	w.	w.	PROPN
admet-2043	1353	5	zhang	zhang	PROPN
admet-2043	1353	6	,	,	PUNCT
admet-2043	1353	7	a.	a.	PROPN
admet-2043	1353	8	mehta	mehta	PROPN
admet-2043	1353	9	,	,	PUNCT
admet-2043	1353	10	z.	z.	PROPN
admet-2043	1353	11	tong	tong	PROPN
admet-2043	1353	12	,	,	PUNCT
admet-2043	1353	13	l.	l.	PROPN
admet-2043	1353	14	esser	esser	PROPN
admet-2043	1353	15	,	,	PUNCT
admet-2043	1353	16	n.h	n.h	PROPN
admet-2043	1353	17	.	.	PROPN
admet-2043	1353	18	voelcker	voelcker	PROPN
admet-2043	1353	19	.	.	PUNCT
admet-2043	1354	1	development	development	NOUN
admet-2043	1354	2	of	of	ADP
admet-2043	1354	3	polymeric	polymeric	ADJ
admet-2043	1354	4	nanoparticles	nanoparticle	NOUN
admet-2043	1354	5	for	for	ADP
admet-2043	1354	6	blood	blood	NOUN
admet-2043	1354	7	-	-	PUNCT
admet-2043	1354	8	brain	brain	NOUN
admet-2043	1354	9	barrier	barrier	NOUN
admet-2043	1354	10	transfer	transfer	NOUN
admet-2043	1354	11	-	-	PUNCT
admet-2043	1354	12	strategies	strategy	NOUN
admet-2043	1354	13	and	and	CCONJ
admet-2043	1354	14	challenges	challenge	NOUN
admet-2043	1354	15	.	.	PUNCT
admet-2043	1355	1	advanced	advanced	ADJ
admet-2043	1355	2	science	science	NOUN
admet-2043	1355	3	8	8	NUM
admet-2043	1355	4	(	(	PUNCT
admet-2043	1355	5	2021	2021	NUM
admet-2043	1355	6	)	)	PUNCT
admet-2043	1355	7	2003937	2003937	NUM
admet-2043	1355	8	.	.	PUNCT
admet-2043	1356	1	https://doi.org/10.1002/advs.202003937	https://doi.org/10.1002/advs.202003937	X
admet-2043	1356	2	.	.	PUNCT
admet-2043	1357	1	[	[	X
admet-2043	1357	2	153	153	NUM
admet-2043	1357	3	]	]	X
admet-2043	1357	4	d.m	d.m	PROPN
admet-2043	1357	5	.	.	PROPN
admet-2043	1357	6	teleanu	teleanu	PROPN
admet-2043	1357	7	,	,	PUNCT
admet-2043	1357	8	i.	i.	NOUN
admet-2043	1357	9	negut	negut	PROPN
admet-2043	1357	10	,	,	PUNCT
admet-2043	1357	11	v.	v.	ADP
admet-2043	1357	12	grumezescu	grumezescu	PROPN
admet-2043	1357	13	,	,	PUNCT
admet-2043	1357	14	a.m.	a.m.	PROPN
admet-2043	1357	15	grumezescu	grumezescu	PROPN
admet-2043	1357	16	,	,	PUNCT
admet-2043	1357	17	r.i	r.i	PROPN
admet-2043	1357	18	.	.	PROPN
admet-2043	1357	19	teleanu	teleanu	PROPN
admet-2043	1357	20	.	.	PUNCT
admet-2043	1358	1	nanomaterials	nanomaterial	NOUN
admet-2043	1358	2	for	for	ADP
admet-2043	1358	3	drug	drug	NOUN
admet-2043	1358	4	delivery	delivery	NOUN
admet-2043	1358	5	to	to	ADP
admet-2043	1358	6	the	the	DET
admet-2043	1358	7	central	central	ADJ
admet-2043	1358	8	nervous	nervous	ADJ
admet-2043	1358	9	system	system	NOUN
admet-2043	1358	10	.	.	PUNCT
admet-2043	1359	1	nanomaterials	nanomaterial	NOUN
admet-2043	1359	2	(	(	PUNCT
admet-2043	1359	3	basel	basel	PROPN
admet-2043	1359	4	)	)	PUNCT
admet-2043	1359	5	9	9	NUM
admet-2043	1359	6	(	(	PUNCT
admet-2043	1359	7	2019	2019	NUM
admet-2043	1359	8	)	)	PUNCT
admet-2043	1359	9	.	.	PUNCT
admet-2043	1360	1	https://doi.org/10.3390/nano9030371	https://doi.org/10.3390/nano9030371	PROPN
admet-2043	1360	2	.	.	PUNCT
admet-2043	1361	1	[	[	X
admet-2043	1361	2	154	154	NUM
admet-2043	1361	3	]	]	X
admet-2043	1361	4	a.e	a.e	PROPN
admet-2043	1361	5	.	.	PROPN
admet-2043	1361	6	nel	nel	PROPN
admet-2043	1361	7	,	,	PUNCT
admet-2043	1361	8	l.	l.	PROPN
admet-2043	1361	9	madler	madler	PROPN
admet-2043	1361	10	,	,	PUNCT
admet-2043	1361	11	d.	d.	PROPN
admet-2043	1361	12	velegol	velegol	PROPN
admet-2043	1361	13	,	,	PUNCT
admet-2043	1361	14	t.	t.	PROPN
admet-2043	1361	15	xia	xia	PROPN
admet-2043	1361	16	,	,	PUNCT
admet-2043	1361	17	e.m	e.m	PROPN
admet-2043	1361	18	.	.	PROPN
admet-2043	1361	19	hoek	hoek	PROPN
admet-2043	1361	20	,	,	PUNCT
admet-2043	1361	21	p.	p.	NOUN
admet-2043	1361	22	somasundaran	somasundaran	PROPN
admet-2043	1361	23	,	,	PUNCT
admet-2043	1361	24	f.	f.	PROPN
admet-2043	1361	25	klaessig	klaessig	PROPN
admet-2043	1361	26	,	,	PUNCT
admet-2043	1361	27	v.	v.	ADP
admet-2043	1361	28	castranova	castranova	NOUN
admet-2043	1361	29	,	,	PUNCT
admet-2043	1361	30	m.	m.	NOUN
admet-2043	1361	31	thompson	thompson	PROPN
admet-2043	1361	32	.	.	PUNCT
admet-2043	1362	1	understanding	understand	VERB
admet-2043	1362	2	biophysicochemical	biophysicochemical	ADJ
admet-2043	1362	3	interactions	interaction	NOUN
admet-2043	1362	4	at	at	ADP
admet-2043	1362	5	the	the	DET
admet-2043	1362	6	nano	nano	NOUN
admet-2043	1362	7	-	-	PUNCT
admet-2043	1362	8	bio	bio	NOUN
admet-2043	1362	9	interface	interface	NOUN
admet-2043	1362	10	.	.	PUNCT
admet-2043	1363	1	nature	nature	NOUN
admet-2043	1363	2	materials	material	NOUN
admet-2043	1363	3	8	8	NUM
admet-2043	1363	4	(	(	PUNCT
admet-2043	1363	5	2009	2009	NUM
admet-2043	1363	6	)	)	PUNCT
admet-2043	1363	7	543	543	NUM
admet-2043	1363	8	-	-	SYM
admet-2043	1363	9	557	557	NUM
admet-2043	1363	10	.	.	PUNCT
admet-2043	1364	1	https://doi.org/10.1038/nmat2442	https://doi.org/10.1038/nmat2442	NOUN
admet-2043	1364	2	.	.	PUNCT
admet-2043	1365	1	[	[	X
admet-2043	1365	2	155	155	NUM
admet-2043	1365	3	]	]	SYM
admet-2043	1365	4	s.b	s.b	PROPN
admet-2043	1365	5	.	.	PROPN
admet-2043	1365	6	tiwari	tiwari	PROPN
admet-2043	1365	7	,	,	PUNCT
admet-2043	1365	8	m.m	m.m	PROPN
admet-2043	1365	9	.	.	PROPN
admet-2043	1365	10	amiji	amiji	PROPN
admet-2043	1365	11	.	.	PUNCT
admet-2043	1366	1	a	a	DET
admet-2043	1366	2	review	review	NOUN
admet-2043	1366	3	of	of	ADP
admet-2043	1366	4	nanocarrier	nanocarrier	NOUN
admet-2043	1366	5	-	-	PUNCT
admet-2043	1366	6	based	base	VERB
admet-2043	1366	7	cns	cns	NOUN
admet-2043	1366	8	delivery	delivery	NOUN
admet-2043	1366	9	systems	system	NOUN
admet-2043	1366	10	.	.	PUNCT
admet-2043	1367	1	current	current	ADJ
admet-2043	1367	2	drug	drug	NOUN
admet-2043	1367	3	delivery	delivery	NOUN
admet-2043	1367	4	3	3	NUM
admet-2043	1367	5	(	(	PUNCT
admet-2043	1367	6	2006	2006	NUM
admet-2043	1367	7	)	)	PUNCT
admet-2043	1367	8	219	219	NUM
admet-2043	1367	9	-	-	SYM
admet-2043	1367	10	232	232	NUM
admet-2043	1367	11	.	.	PUNCT
admet-2043	1368	1	https://doi.org/10.2174/156720106776359230	https://doi.org/10.2174/156720106776359230	X
admet-2043	1368	2	.	.	PUNCT
admet-2043	1369	1	[	[	X
admet-2043	1369	2	156	156	NUM
admet-2043	1369	3	]	]	X
admet-2043	1369	4	g.	g.	PROPN
admet-2043	1369	5	liu	liu	PROPN
admet-2043	1369	6	,	,	PUNCT
admet-2043	1369	7	p.	p.	NOUN
admet-2043	1369	8	men	man	NOUN
admet-2043	1369	9	,	,	PUNCT
admet-2043	1369	10	p.l	p.l	PROPN
admet-2043	1369	11	.	.	PROPN
admet-2043	1369	12	harris	harris	PROPN
admet-2043	1369	13	,	,	PUNCT
admet-2043	1369	14	r.k	r.k	PROPN
admet-2043	1369	15	.	.	PROPN
admet-2043	1369	16	rolston	rolston	PROPN
admet-2043	1369	17	,	,	PUNCT
admet-2043	1369	18	g.	g.	PROPN
admet-2043	1369	19	perry	perry	PROPN
admet-2043	1369	20	,	,	PUNCT
admet-2043	1369	21	m.a	m.a	PROPN
admet-2043	1369	22	.	.	PROPN
admet-2043	1369	23	smith	smith	PROPN
admet-2043	1369	24	.	.	PUNCT
admet-2043	1370	1	nanoparticle	nanoparticle	PROPN
admet-2043	1370	2	iron	iron	NOUN
admet-2043	1370	3	chelators	chelator	NOUN
admet-2043	1370	4	:	:	PUNCT
admet-2043	1370	5	a	a	DET
admet-2043	1370	6	new	new	ADJ
admet-2043	1370	7	therapeutic	therapeutic	ADJ
admet-2043	1370	8	approach	approach	NOUN
admet-2043	1370	9	in	in	ADP
admet-2043	1370	10	alzheimer	alzheimer	PROPN
admet-2043	1370	11	disease	disease	NOUN
admet-2043	1370	12	and	and	CCONJ
admet-2043	1370	13	other	other	ADJ
admet-2043	1370	14	neurologic	neurologic	ADJ
admet-2043	1370	15	disorders	disorder	NOUN
admet-2043	1370	16	associated	associate	VERB
admet-2043	1370	17	with	with	ADP
admet-2043	1370	18	trace	trace	NOUN
admet-2043	1370	19	metal	metal	NOUN
admet-2043	1370	20	imbalance	imbalance	NOUN
admet-2043	1370	21	.	.	PUNCT
admet-2043	1371	1	neuroscience	neuroscience	NOUN
admet-2043	1371	2	letters	letter	NOUN
admet-2043	1371	3	406	406	NUM
admet-2043	1371	4	(	(	PUNCT
admet-2043	1371	5	2006	2006	NUM
admet-2043	1371	6	)	)	PUNCT
admet-2043	1371	7	189	189	NUM
admet-2043	1371	8	-	-	SYM
admet-2043	1371	9	193	193	NUM
admet-2043	1371	10	.	.	PUNCT
admet-2043	1372	1	https://doi.org/10.1016/j.neulet.2006.07.020	https://doi.org/10.1016/j.neulet.2006.07.020	VERB
admet-2043	1372	2	.	.	PUNCT
admet-2043	1373	1	[	[	X
admet-2043	1373	2	157	157	NUM
admet-2043	1373	3	]	]	PUNCT
admet-2043	1373	4	j.	j.	PROPN
admet-2043	1373	5	kreuter	kreuter	PROPN
admet-2043	1373	6	.	.	PUNCT
admet-2043	1374	1	influence	influence	NOUN
admet-2043	1374	2	of	of	ADP
admet-2043	1374	3	the	the	DET
admet-2043	1374	4	surface	surface	NOUN
admet-2043	1374	5	properties	property	NOUN
admet-2043	1374	6	on	on	ADP
admet-2043	1374	7	nanoparticle	nanoparticle	NOUN
admet-2043	1374	8	-	-	PUNCT
admet-2043	1374	9	mediated	mediate	VERB
admet-2043	1374	10	transport	transport	NOUN
admet-2043	1374	11	of	of	ADP
admet-2043	1374	12	drugs	drug	NOUN
admet-2043	1374	13	to	to	ADP
admet-2043	1374	14	the	the	DET
admet-2043	1374	15	brain	brain	NOUN
admet-2043	1374	16	.	.	PUNCT
admet-2043	1375	1	journal	journal	PROPN
admet-2043	1375	2	of	of	ADP
admet-2043	1375	3	nanoscience	nanoscience	PROPN
admet-2043	1375	4	and	and	CCONJ
admet-2043	1375	5	nanotechnology	nanotechnology	NOUN
admet-2043	1375	6	4	4	NUM
admet-2043	1375	7	(	(	PUNCT
admet-2043	1375	8	2004	2004	NUM
admet-2043	1375	9	)	)	PUNCT
admet-2043	1375	10	484	484	NUM
admet-2043	1375	11	-	-	SYM
admet-2043	1375	12	488	488	NUM
admet-2043	1375	13	.	.	PUNCT
admet-2043	1376	1	https://doi.org/10.1166/jnn.2003.077	https://doi.org/10.1166/jnn.2003.077	PROPN
admet-2043	1376	2	.	.	PUNCT
admet-2043	1377	1	[	[	X
admet-2043	1377	2	158	158	X
admet-2043	1377	3	]	]	X
admet-2043	1377	4	b.	b.	PROPN
admet-2043	1377	5	hagenbuch	hagenbuch	PROPN
admet-2043	1377	6	,	,	PUNCT
admet-2043	1377	7	p.j	p.j	PROPN
admet-2043	1377	8	.	.	PROPN
admet-2043	1377	9	meier	meier	PROPN
admet-2043	1377	10	.	.	PUNCT
admet-2043	1378	1	the	the	DET
admet-2043	1378	2	superfamily	superfamily	NOUN
admet-2043	1378	3	of	of	ADP
admet-2043	1378	4	organic	organic	ADJ
admet-2043	1378	5	anion	anion	NOUN
admet-2043	1378	6	transporting	transport	VERB
admet-2043	1378	7	polypeptides	polypeptide	NOUN
admet-2043	1378	8	.	.	PUNCT
admet-2043	1379	1	biochimica	biochimica	PROPN
admet-2043	1379	2	et	et	PROPN
admet-2043	1379	3	biophysica	biophysica	PROPN
admet-2043	1379	4	acta	acta	PROPN
admet-2043	1379	5	1609	1609	NUM
admet-2043	1379	6	(	(	PUNCT
admet-2043	1379	7	2003	2003	NUM
admet-2043	1379	8	)	)	PUNCT
admet-2043	1379	9	1	1	NUM
admet-2043	1379	10	-	-	SYM
admet-2043	1379	11	18	18	NUM
admet-2043	1379	12	.	.	PUNCT
admet-2043	1379	13	https://doi.org/10.1016/s0005-2736(02)00633-8	https://doi.org/10.1016/s0005-2736(02)00633-8	NOUN
admet-2043	1379	14	.	.	PUNCT
admet-2043	1380	1	[	[	X
admet-2043	1380	2	159	159	NUM
admet-2043	1380	3	]	]	PUNCT
admet-2043	1380	4	l.	l.	PROPN
admet-2043	1380	5	fenart	fenart	PROPN
admet-2043	1380	6	,	,	PUNCT
admet-2043	1380	7	a.	a.	PROPN
admet-2043	1380	8	casanova	casanova	PROPN
admet-2043	1380	9	,	,	PUNCT
admet-2043	1380	10	b.	b.	PROPN
admet-2043	1380	11	dehouck	dehouck	PROPN
admet-2043	1380	12	,	,	PUNCT
admet-2043	1380	13	c.	c.	PROPN
admet-2043	1380	14	duhem	duhem	PROPN
admet-2043	1380	15	,	,	PUNCT
admet-2043	1380	16	s.	s.	PROPN
admet-2043	1380	17	slupek	slupek	PROPN
admet-2043	1380	18	,	,	PUNCT
admet-2043	1380	19	r.	r.	PROPN
admet-2043	1380	20	cecchelli	cecchelli	PROPN
admet-2043	1380	21	,	,	PUNCT
admet-2043	1380	22	d.	d.	PROPN
admet-2043	1380	23	betbeder	betbeder	NOUN
admet-2043	1380	24	.	.	PUNCT
admet-2043	1381	1	evaluation	evaluation	NOUN
admet-2043	1381	2	of	of	ADP
admet-2043	1381	3	effect	effect	NOUN
admet-2043	1381	4	of	of	ADP
admet-2043	1381	5	charge	charge	NOUN
admet-2043	1381	6	and	and	CCONJ
admet-2043	1381	7	lipid	lipid	NOUN
admet-2043	1381	8	coating	coating	NOUN
admet-2043	1381	9	on	on	ADP
admet-2043	1381	10	ability	ability	NOUN
admet-2043	1381	11	of	of	ADP
admet-2043	1381	12	60	60	NUM
admet-2043	1381	13	-	-	PUNCT
admet-2043	1381	14	nm	nm	NOUN
admet-2043	1381	15	nanoparticles	nanoparticle	NOUN
admet-2043	1381	16	to	to	PART
admet-2043	1381	17	cross	cross	VERB
admet-2043	1381	18	an	an	DET
admet-2043	1381	19	in	in	X
admet-2043	1381	20	vitro	vitro	X
admet-2043	1381	21	model	model	NOUN
admet-2043	1381	22	of	of	ADP
admet-2043	1381	23	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1381	24	https://doi.org/10.1016/s0169-409x(98)00083-0	https://doi.org/10.1016/s0169-409x(98)00083-0	ADV
admet-2043	1381	25	https://doi.org/10.1016/s0169-409x(98)00083-0	https://doi.org/10.1016/s0169-409x(98)00083-0	ADV
admet-2043	1381	26	https://doi.org/10.1016/j.jbiomech.2009.09.022	https://doi.org/10.1016/j.jbiomech.2009.09.022	VERB
admet-2043	1381	27	https://doi.org/10.2147/ijn.s327737	https://doi.org/10.2147/ijn.s327737	ADJ
admet-2043	1381	28	https://doi.org/10.1177/0271678x16630991	https://doi.org/10.1177/0271678x16630991	ADJ
admet-2043	1381	29	https://doi.org/10.1038%2fnprot.2012.051	https://doi.org/10.1038%2fnprot.2012.051	ADJ
admet-2043	1381	30	https://doi.org/10.1002/btm2.10126	https://doi.org/10.1002/btm2.10126	PROPN
admet-2043	1381	31	https://doi.org/10.1007/s10545-013-9608-0	https://doi.org/10.1007/s10545-013-9608-0	PROPN
admet-2043	1381	32	https://doi.org/10.1007/s10545-013-9608-0	https://doi.org/10.1007/s10545-013-9608-0	NUM
admet-2043	1381	33	https://doi.org/10.1007/s10544-012-9669-0	https://doi.org/10.1007/s10544-012-9669-0	NUM
admet-2043	1381	34	https://doi.org/10.1002/advs.202003937	https://doi.org/10.1002/advs.202003937	NOUN
admet-2043	1381	35	https://doi.org/10.3390/nano9030371	https://doi.org/10.3390/nano9030371	PROPN
admet-2043	1381	36	https://doi.org/10.1038/nmat2442	https://doi.org/10.1038/nmat2442	NOUN
admet-2043	1381	37	https://doi.org/10.2174/156720106776359230	https://doi.org/10.2174/156720106776359230	PROPN
admet-2043	1381	38	https://doi.org/10.1016/j.neulet.2006.07.020	https://doi.org/10.1016/j.neulet.2006.07.020	VERB
admet-2043	1381	39	https://doi.org/10.1166/jnn.2003.077	https://doi.org/10.1166/jnn.2003.077	PROPN
admet-2043	1381	40	https://doi.org/10.1016/s0005-2736(02)00633-8	https://doi.org/10.1016/s0005-2736(02)00633-8	PROPN
admet-2043	1381	41	m.	m.	NOUN
admet-2043	1381	42	kulkarni	kulkarni	PROPN
admet-2043	1381	43	et	et	PROPN
admet-2043	1381	44	al	al	PROPN
admet-2043	1381	45	.	.	PROPN
admet-2043	1381	46	admet	admet	PROPN
admet-2043	1381	47	&	&	CCONJ
admet-2043	1381	48	dmpk	dmpk	PROPN
admet-2043	1381	49	12(1	12(1	PROPN
admet-2043	1381	50	)	)	PUNCT
admet-2043	1381	51	(	(	PUNCT
admet-2043	1381	52	2024	2024	NUM
admet-2043	1381	53	)	)	PUNCT
admet-2043	1381	54	63	63	NUM
admet-2043	1381	55	-	-	SYM
admet-2043	1381	56	105	105	NUM
admet-2043	1381	57	102	102	NUM
admet-2043	1381	58	the	the	DET
admet-2043	1381	59	blood	blood	NOUN
admet-2043	1381	60	-	-	PUNCT
admet-2043	1381	61	brain	brain	NOUN
admet-2043	1381	62	barrier	barrier	NOUN
admet-2043	1381	63	.	.	PUNCT
admet-2043	1382	1	journal	journal	PROPN
admet-2043	1382	2	of	of	ADP
admet-2043	1382	3	pharmacology	pharmacology	NOUN
admet-2043	1382	4	and	and	CCONJ
admet-2043	1382	5	experimental	experimental	ADJ
admet-2043	1382	6	therapeutics	therapeutic	NOUN
admet-2043	1382	7	291	291	NUM
admet-2043	1382	8	(	(	PUNCT
admet-2043	1382	9	1999	1999	NUM
admet-2043	1382	10	)	)	PUNCT
admet-2043	1382	11	10171022	10171022	NUM
admet-2043	1382	12	.	.	PUNCT
admet-2043	1383	1	https://doi.org/https://www.ncbi.nlm.nih.gov/pubmed/10565819	https://doi.org/https://www.ncbi.nlm.nih.gov/pubmed/10565819	NOUN
admet-2043	1383	2	.	.	PUNCT
admet-2043	1384	1	[	[	X
admet-2043	1384	2	160	160	NUM
admet-2043	1384	3	]	]	X
admet-2043	1384	4	g.	g.	PROPN
admet-2043	1384	5	sahagun	sahagun	PROPN
admet-2043	1384	6	,	,	PUNCT
admet-2043	1384	7	s.a	s.a	PROPN
admet-2043	1384	8	.	.	PROPN
admet-2043	1384	9	moore	moore	PROPN
admet-2043	1384	10	,	,	PUNCT
admet-2043	1384	11	m.n	m.n	PROPN
admet-2043	1384	12	.	.	PROPN
admet-2043	1384	13	hart	hart	PROPN
admet-2043	1384	14	.	.	PUNCT
admet-2043	1385	1	permeability	permeability	NOUN
admet-2043	1385	2	of	of	ADP
admet-2043	1385	3	neutral	neutral	ADJ
admet-2043	1385	4	vs.	vs.	X
admet-2043	1385	5	anionic	anionic	ADJ
admet-2043	1385	6	dextrans	dextran	NOUN
admet-2043	1385	7	in	in	ADP
admet-2043	1385	8	cultured	cultured	ADJ
admet-2043	1385	9	brain	brain	NOUN
admet-2043	1385	10	microvascular	microvascular	NOUN
admet-2043	1385	11	endothelium	endothelium	NOUN
admet-2043	1385	12	.	.	PUNCT
admet-2043	1386	1	american	american	ADJ
admet-2043	1386	2	journal	journal	PROPN
admet-2043	1386	3	of	of	ADP
admet-2043	1386	4	physiology	physiology	NOUN
admet-2043	1386	5	259	259	NUM
admet-2043	1386	6	(	(	PUNCT
admet-2043	1386	7	1990	1990	NUM
admet-2043	1386	8	)	)	PUNCT
admet-2043	1386	9	h162	h162	PROPN
admet-2043	1386	10	-	-	SYM
admet-2043	1386	11	166	166	NUM
admet-2043	1386	12	.	.	PUNCT
admet-2043	1387	1	https://doi.org/10.1152/ajpheart.1990.259.1.h162	https://doi.org/10.1152/ajpheart.1990.259.1.h162	NOUN
admet-2043	1387	2	.	.	PUNCT
admet-2043	1388	1	[	[	X
admet-2043	1388	2	161	161	NUM
admet-2043	1388	3	]	]	X
admet-2043	1388	4	p.r	p.r	PROPN
admet-2043	1388	5	.	.	PROPN
admet-2043	1388	6	lockman	lockman	PROPN
admet-2043	1388	7	,	,	PUNCT
admet-2043	1388	8	j.m	j.m	PROPN
admet-2043	1388	9	.	.	PROPN
admet-2043	1388	10	koziara	koziara	PROPN
admet-2043	1388	11	,	,	PUNCT
admet-2043	1388	12	r.j	r.j	PROPN
admet-2043	1388	13	.	.	PROPN
admet-2043	1388	14	mumper	mumper	PROPN
admet-2043	1388	15	,	,	PUNCT
admet-2043	1388	16	d.d	d.d	PROPN
admet-2043	1388	17	.	.	PROPN
admet-2043	1388	18	allen	allen	PROPN
admet-2043	1388	19	.	.	PROPN
admet-2043	1388	20	nanoparticle	nanoparticle	PROPN
admet-2043	1388	21	surface	surface	NOUN
admet-2043	1388	22	charges	charge	NOUN
admet-2043	1388	23	alter	alter	VERB
admet-2043	1388	24	bloodbrain	bloodbrain	NOUN
admet-2043	1388	25	barrier	barrier	NOUN
admet-2043	1388	26	integrity	integrity	NOUN
admet-2043	1388	27	and	and	CCONJ
admet-2043	1388	28	permeability	permeability	NOUN
admet-2043	1388	29	.	.	PUNCT
admet-2043	1389	1	journal	journal	PROPN
admet-2043	1389	2	of	of	ADP
admet-2043	1389	3	drug	drug	NOUN
admet-2043	1389	4	targeting	target	VERB
admet-2043	1389	5	12	12	NUM
admet-2043	1389	6	(	(	PUNCT
admet-2043	1389	7	2004	2004	NUM
admet-2043	1389	8	)	)	PUNCT
admet-2043	1389	9	635	635	NUM
admet-2043	1389	10	-	-	SYM
admet-2043	1389	11	641	641	NUM
admet-2043	1389	12	.	.	PUNCT
admet-2043	1390	1	https://doi.org/10.1080/10611860400015936	https://doi.org/10.1080/10611860400015936	NOUN
admet-2043	1390	2	.	.	PUNCT
admet-2043	1391	1	[	[	X
admet-2043	1391	2	162	162	NUM
admet-2043	1391	3	]	]	X
admet-2043	1391	4	j.m	j.m	PROPN
admet-2043	1391	5	.	.	PROPN
admet-2043	1391	6	koziara	koziara	PROPN
admet-2043	1391	7	,	,	PUNCT
admet-2043	1391	8	p.r	p.r	PROPN
admet-2043	1391	9	.	.	PROPN
admet-2043	1391	10	lockman	lockman	PROPN
admet-2043	1391	11	,	,	PUNCT
admet-2043	1391	12	d.d	d.d	PROPN
admet-2043	1391	13	.	.	PROPN
admet-2043	1391	14	allen	allen	PROPN
admet-2043	1391	15	,	,	PUNCT
admet-2043	1391	16	r.j	r.j	PROPN
admet-2043	1391	17	.	.	PROPN
admet-2043	1391	18	mumper	mumper	NOUN
admet-2043	1391	19	.	.	PUNCT
admet-2043	1392	1	the	the	DET
admet-2043	1392	2	blood	blood	NOUN
admet-2043	1392	3	-	-	PUNCT
admet-2043	1392	4	brain	brain	NOUN
admet-2043	1392	5	barrier	barrier	NOUN
admet-2043	1392	6	and	and	CCONJ
admet-2043	1392	7	brain	brain	NOUN
admet-2043	1392	8	drug	drug	NOUN
admet-2043	1392	9	delivery	delivery	NOUN
admet-2043	1392	10	.	.	PUNCT
admet-2043	1393	1	journal	journal	PROPN
admet-2043	1393	2	of	of	ADP
admet-2043	1393	3	nanoscience	nanoscience	PROPN
admet-2043	1393	4	and	and	CCONJ
admet-2043	1393	5	nanotechnology	nanotechnology	NOUN
admet-2043	1393	6	6	6	NUM
admet-2043	1393	7	(	(	PUNCT
admet-2043	1393	8	2006	2006	NUM
admet-2043	1393	9	)	)	PUNCT
admet-2043	1393	10	2712	2712	NUM
admet-2043	1393	11	-	-	SYM
admet-2043	1393	12	2735	2735	NUM
admet-2043	1393	13	.	.	PUNCT
admet-2043	1394	1	https://doi.org/10.1166/jnn.2006.441	https://doi.org/10.1166/jnn.2006.441	NOUN
admet-2043	1394	2	.	.	PUNCT
admet-2043	1395	1	[	[	X
admet-2043	1395	2	163	163	NUM
admet-2043	1395	3	]	]	X
admet-2043	1395	4	t.d	t.d	PROPN
admet-2043	1395	5	.	.	PROPN
admet-2043	1395	6	brown	brown	PROPN
admet-2043	1395	7	,	,	PUNCT
admet-2043	1395	8	n.	n.	PROPN
admet-2043	1395	9	habibi	habibi	PROPN
admet-2043	1395	10	,	,	PUNCT
admet-2043	1395	11	d.	d.	PROPN
admet-2043	1395	12	wu	wu	PROPN
admet-2043	1395	13	,	,	PUNCT
admet-2043	1395	14	j.	j.	PROPN
admet-2043	1395	15	lahann	lahann	PROPN
admet-2043	1395	16	,	,	PUNCT
admet-2043	1395	17	s.	s.	PROPN
admet-2043	1395	18	mitragotri	mitragotri	PROPN
admet-2043	1395	19	.	.	PUNCT
admet-2043	1396	1	effect	effect	NOUN
admet-2043	1396	2	of	of	ADP
admet-2043	1396	3	nanoparticle	nanoparticle	NOUN
admet-2043	1396	4	composition	composition	NOUN
admet-2043	1396	5	,	,	PUNCT
admet-2043	1396	6	size	size	NOUN
admet-2043	1396	7	,	,	PUNCT
admet-2043	1396	8	shape	shape	NOUN
admet-2043	1396	9	,	,	PUNCT
admet-2043	1396	10	and	and	CCONJ
admet-2043	1396	11	stiffness	stiffness	NOUN
admet-2043	1396	12	on	on	ADP
admet-2043	1396	13	penetration	penetration	NOUN
admet-2043	1396	14	across	across	ADP
admet-2043	1396	15	the	the	DET
admet-2043	1396	16	blood	blood	NOUN
admet-2043	1396	17	-	-	PUNCT
admet-2043	1396	18	brain	brain	NOUN
admet-2043	1396	19	barrier	barrier	NOUN
admet-2043	1396	20	.	.	PUNCT
admet-2043	1397	1	acs	acs	PROPN
admet-2043	1397	2	biomaterials	biomaterials	PROPN
admet-2043	1397	3	science	science	PROPN
admet-2043	1397	4	&	&	CCONJ
admet-2043	1397	5	engineering	engineering	PROPN
admet-2043	1397	6	6	6	NUM
admet-2043	1397	7	(	(	PUNCT
admet-2043	1397	8	2020	2020	NUM
admet-2043	1397	9	)	)	PUNCT
admet-2043	1397	10	4916	4916	NUM
admet-2043	1397	11	-	-	SYM
admet-2043	1397	12	4928	4928	NUM
admet-2043	1397	13	.	.	PUNCT
admet-2043	1398	1	https://doi.org/10.1021/acsbiomaterials.0c00743	https://doi.org/10.1021/acsbiomaterials.0c00743	NOUN
admet-2043	1398	2	.	.	PUNCT
admet-2043	1399	1	[	[	X
admet-2043	1399	2	164	164	NUM
admet-2043	1399	3	]	]	X
admet-2043	1399	4	f.	f.	PROPN
admet-2043	1399	5	re	re	PROPN
admet-2043	1399	6	,	,	PUNCT
admet-2043	1399	7	m.	m.	PROPN
admet-2043	1399	8	gregori	gregori	PROPN
admet-2043	1399	9	,	,	PUNCT
admet-2043	1399	10	m.	m.	NOUN
admet-2043	1399	11	masserini	masserini	PROPN
admet-2043	1399	12	.	.	PUNCT
admet-2043	1400	1	nanotechnology	nanotechnology	PROPN
admet-2043	1400	2	for	for	ADP
admet-2043	1400	3	neurodegenerative	neurodegenerative	ADJ
admet-2043	1400	4	disorders	disorder	NOUN
admet-2043	1400	5	.	.	PUNCT
admet-2043	1401	1	maturitas	maturita	VERB
admet-2043	1401	2	73	73	NUM
admet-2043	1401	3	(	(	PUNCT
admet-2043	1401	4	2012	2012	NUM
admet-2043	1401	5	)	)	PUNCT
admet-2043	1401	6	45	45	NUM
admet-2043	1401	7	-	-	SYM
admet-2043	1401	8	51	51	NUM
admet-2043	1401	9	.	.	PUNCT
admet-2043	1402	1	https://doi.org/10.1016/j.maturitas.2011.12.015	https://doi.org/10.1016/j.maturitas.2011.12.015	PROPN
admet-2043	1402	2	.	.	PUNCT
admet-2043	1403	1	[	[	X
admet-2043	1403	2	165	165	NUM
admet-2043	1403	3	]	]	PUNCT
admet-2043	1403	4	m.	m.	NOUN
admet-2043	1403	5	li	li	PROPN
admet-2043	1403	6	,	,	PUNCT
admet-2043	1403	7	c.	c.	PROPN
admet-2043	1403	8	du	du	PROPN
admet-2043	1403	9	,	,	PUNCT
admet-2043	1403	10	n.	n.	PROPN
admet-2043	1403	11	guo	guo	PROPN
admet-2043	1403	12	,	,	PUNCT
admet-2043	1403	13	y.	y.	PROPN
admet-2043	1403	14	teng	teng	PROPN
admet-2043	1403	15	,	,	PUNCT
admet-2043	1403	16	x.	x.	PROPN
admet-2043	1403	17	meng	meng	PROPN
admet-2043	1403	18	,	,	PUNCT
admet-2043	1403	19	h.	h.	PROPN
admet-2043	1403	20	sun	sun	PROPN
admet-2043	1403	21	,	,	PUNCT
admet-2043	1403	22	s.	s.	PROPN
admet-2043	1403	23	li	li	PROPN
admet-2043	1403	24	,	,	PUNCT
admet-2043	1403	25	p.	p.	PROPN
admet-2043	1403	26	yu	yu	PROPN
admet-2043	1403	27	,	,	PUNCT
admet-2043	1403	28	h.	h.	PROPN
admet-2043	1403	29	galons	galons	PROPN
admet-2043	1403	30	.	.	PUNCT
admet-2043	1403	31	composition	composition	NOUN
admet-2043	1403	32	design	design	NOUN
admet-2043	1403	33	and	and	CCONJ
admet-2043	1403	34	medical	medical	ADJ
admet-2043	1403	35	application	application	NOUN
admet-2043	1403	36	of	of	ADP
admet-2043	1403	37	liposomes	liposome	NOUN
admet-2043	1403	38	.	.	PUNCT
admet-2043	1404	1	european	european	PROPN
admet-2043	1404	2	journal	journal	PROPN
admet-2043	1404	3	of	of	ADP
admet-2043	1404	4	medicinal	medicinal	ADJ
admet-2043	1404	5	chemistry	chemistry	NOUN
admet-2043	1404	6	164	164	NUM
admet-2043	1404	7	(	(	PUNCT
admet-2043	1404	8	2019	2019	NUM
admet-2043	1404	9	)	)	PUNCT
admet-2043	1404	10	640	640	NUM
admet-2043	1404	11	-	-	SYM
admet-2043	1404	12	653	653	NUM
admet-2043	1404	13	.	.	PUNCT
admet-2043	1405	1	https://doi.org/10.1016/j.ejmech.2019.01.007	https://doi.org/10.1016/j.ejmech.2019.01.007	ADJ
admet-2043	1405	2	.	.	PUNCT
admet-2043	1406	1	[	[	X
admet-2043	1406	2	166	166	NUM
admet-2043	1406	3	]	]	SYM
admet-2043	1406	4	v.j	v.j	PROPN
admet-2043	1406	5	.	.	PROPN
admet-2043	1406	6	muniswamy	muniswamy	PROPN
admet-2043	1406	7	,	,	PUNCT
admet-2043	1406	8	n.	n.	NOUN
admet-2043	1406	9	raval	raval	NOUN
admet-2043	1406	10	,	,	PUNCT
admet-2043	1406	11	p.	p.	PROPN
admet-2043	1406	12	gondaliya	gondaliya	PROPN
admet-2043	1406	13	,	,	PUNCT
admet-2043	1406	14	v.	v.	ADP
admet-2043	1406	15	tambe	tambe	NOUN
admet-2043	1406	16	,	,	PUNCT
admet-2043	1406	17	k.	k.	PROPN
admet-2043	1406	18	kalia	kalia	PROPN
admet-2043	1406	19	,	,	PUNCT
admet-2043	1406	20	r.k	r.k	PROPN
admet-2043	1406	21	.	.	PROPN
admet-2043	1406	22	tekade	tekade	PROPN
admet-2043	1406	23	.	.	PUNCT
admet-2043	1407	1	'	'	PUNCT
admet-2043	1407	2	dendrimer	dendrimer	NOUN
admet-2043	1407	3	-	-	PUNCT
admet-2043	1407	4	cationizedalbumin	cationizedalbumin	NOUN
admet-2043	1407	5	'	'	PUNCT
admet-2043	1407	6	encrusted	encrusted	ADJ
admet-2043	1407	7	polymeric	polymeric	ADJ
admet-2043	1407	8	nanoparticle	nanoparticle	NOUN
admet-2043	1407	9	improves	improve	VERB
admet-2043	1407	10	bbb	bbb	NOUN
admet-2043	1407	11	penetration	penetration	NOUN
admet-2043	1407	12	and	and	CCONJ
admet-2043	1407	13	anticancer	anticancer	NOUN
admet-2043	1407	14	activity	activity	NOUN
admet-2043	1407	15	of	of	ADP
admet-2043	1407	16	doxorubicin	doxorubicin	PROPN
admet-2043	1407	17	.	.	PUNCT
admet-2043	1408	1	international	international	ADJ
admet-2043	1408	2	journal	journal	PROPN
admet-2043	1408	3	of	of	ADP
admet-2043	1408	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	1408	5	555	555	NUM
admet-2043	1408	6	(	(	PUNCT
admet-2043	1408	7	2019	2019	NUM
admet-2043	1408	8	)	)	PUNCT
admet-2043	1408	9	77	77	NUM
admet-2043	1408	10	-	-	SYM
admet-2043	1408	11	99	99	NUM
admet-2043	1408	12	.	.	PUNCT
admet-2043	1409	1	https://doi.org/10.1016/j.ijpharm.2018.11.035	https://doi.org/10.1016/j.ijpharm.2018.11.035	PROPN
admet-2043	1409	2	.	.	PUNCT
admet-2043	1410	1	[	[	X
admet-2043	1410	2	167	167	NUM
admet-2043	1410	3	]	]	PUNCT
admet-2043	1410	4	g.	g.	PROPN
admet-2043	1410	5	rajakumar	rajakumar	PROPN
admet-2043	1410	6	,	,	PUNCT
admet-2043	1410	7	x.-h	x.-h	PROPN
admet-2043	1410	8	.	.	PUNCT
admet-2043	1411	1	zhang	zhang	PROPN
admet-2043	1411	2	,	,	PUNCT
admet-2043	1411	3	t.	t.	PROPN
admet-2043	1411	4	gomathi	gomathi	PROPN
admet-2043	1411	5	,	,	PUNCT
admet-2043	1411	6	s.-f	s.-f	PROPN
admet-2043	1411	7	.	.	PUNCT
admet-2043	1412	1	wang	wang	PROPN
admet-2043	1412	2	,	,	PUNCT
admet-2043	1412	3	m.	m.	NOUN
admet-2043	1412	4	azam	azam	PROPN
admet-2043	1412	5	ansari	ansari	PROPN
admet-2043	1412	6	,	,	PUNCT
admet-2043	1412	7	g.	g.	PROPN
admet-2043	1412	8	mydhili	mydhili	PROPN
admet-2043	1412	9	,	,	PUNCT
admet-2043	1412	10	g.	g.	PROPN
admet-2043	1412	11	nirmala	nirmala	PROPN
admet-2043	1412	12	,	,	PUNCT
admet-2043	1412	13	m.a	m.a	PROPN
admet-2043	1412	14	.	.	PROPN
admet-2043	1412	15	alzohairy	alzohairy	PROPN
admet-2043	1412	16	,	,	PUNCT
admet-2043	1412	17	i.-m	i.-m	PROPN
admet-2043	1412	18	.	.	PUNCT
admet-2043	1413	1	chung	chung	PROPN
admet-2043	1413	2	.	.	PUNCT
admet-2043	1414	1	current	current	ADJ
admet-2043	1414	2	use	use	NOUN
admet-2043	1414	3	of	of	ADP
admet-2043	1414	4	carbon	carbon	NOUN
admet-2043	1414	5	-	-	PUNCT
admet-2043	1414	6	based	base	VERB
admet-2043	1414	7	materials	material	NOUN
admet-2043	1414	8	for	for	ADP
admet-2043	1414	9	biomedical	biomedical	ADJ
admet-2043	1414	10	applications	application	NOUN
admet-2043	1414	11	—	—	PUNCT
admet-2043	1414	12	a	a	DET
admet-2043	1414	13	prospective	prospective	ADJ
admet-2043	1414	14	and	and	CCONJ
admet-2043	1414	15	review	review	NOUN
admet-2043	1414	16	.	.	PUNCT
admet-2043	1415	1	processes	process	VERB
admet-2043	1415	2	8	8	NUM
admet-2043	1415	3	(	(	PUNCT
admet-2043	1415	4	2020	2020	NUM
admet-2043	1415	5	)	)	PUNCT
admet-2043	1415	6	355	355	NUM
admet-2043	1415	7	.	.	PUNCT
admet-2043	1416	1	https://doi.org/10.3390/pr8030355	https://doi.org/10.3390/pr8030355	X
admet-2043	1416	2	.	.	PUNCT
admet-2043	1417	1	[	[	X
admet-2043	1417	2	168	168	NUM
admet-2043	1417	3	]	]	X
admet-2043	1417	4	x.q	x.q	PROPN
admet-2043	1417	5	.	.	PROPN
admet-2043	1417	6	zhang	zhang	PROPN
admet-2043	1417	7	,	,	PUNCT
admet-2043	1417	8	x.	x.	PROPN
admet-2043	1417	9	xu	xu	PROPN
admet-2043	1417	10	,	,	PUNCT
admet-2043	1417	11	n.	n.	PROPN
admet-2043	1417	12	bertrand	bertrand	PROPN
admet-2043	1417	13	,	,	PUNCT
admet-2043	1417	14	e.	e.	PROPN
admet-2043	1417	15	pridgen	pridgen	PROPN
admet-2043	1417	16	,	,	PUNCT
admet-2043	1417	17	a.	a.	PROPN
admet-2043	1417	18	swami	swami	PROPN
admet-2043	1417	19	,	,	PUNCT
admet-2043	1417	20	o.c	o.c	PROPN
admet-2043	1417	21	.	.	PROPN
admet-2043	1417	22	farokhzad	farokhzad	PROPN
admet-2043	1417	23	.	.	PUNCT
admet-2043	1418	1	interactions	interaction	NOUN
admet-2043	1418	2	of	of	ADP
admet-2043	1418	3	nanomaterials	nanomaterial	NOUN
admet-2043	1418	4	and	and	CCONJ
admet-2043	1418	5	biological	biological	ADJ
admet-2043	1418	6	systems	system	NOUN
admet-2043	1418	7	:	:	PUNCT
admet-2043	1418	8	implications	implication	NOUN
admet-2043	1418	9	to	to	ADP
admet-2043	1418	10	personalized	personalized	ADJ
admet-2043	1418	11	nanomedicine	nanomedicine	NOUN
admet-2043	1418	12	.	.	PUNCT
admet-2043	1419	1	advanced	advanced	ADJ
admet-2043	1419	2	drug	drug	NOUN
admet-2043	1419	3	delivery	delivery	NOUN
admet-2043	1419	4	reviews	review	VERB
admet-2043	1419	5	64	64	NUM
admet-2043	1419	6	(	(	PUNCT
admet-2043	1419	7	2012	2012	NUM
admet-2043	1419	8	)	)	PUNCT
admet-2043	1419	9	1363	1363	NUM
admet-2043	1419	10	-	-	SYM
admet-2043	1419	11	1384	1384	NUM
admet-2043	1419	12	.	.	PUNCT
admet-2043	1420	1	https://doi.org/10.1016/j.addr.2012.08.005	https://doi.org/10.1016/j.addr.2012.08.005	PROPN
admet-2043	1420	2	.	.	PUNCT
admet-2043	1421	1	[	[	X
admet-2043	1421	2	169	169	NUM
admet-2043	1421	3	]	]	X
admet-2043	1421	4	g.	g.	NOUN
admet-2043	1421	5	tosi	tosi	PROPN
admet-2043	1421	6	,	,	PUNCT
admet-2043	1421	7	j.t	j.t	PROPN
admet-2043	1421	8	.	.	PROPN
admet-2043	1421	9	duskey	duskey	PROPN
admet-2043	1421	10	,	,	PUNCT
admet-2043	1421	11	j.	j.	PROPN
admet-2043	1421	12	kreuter	kreuter	PROPN
admet-2043	1421	13	.	.	PUNCT
admet-2043	1422	1	nanoparticles	nanoparticle	NOUN
admet-2043	1422	2	as	as	ADP
admet-2043	1422	3	carriers	carrier	NOUN
admet-2043	1422	4	for	for	ADP
admet-2043	1422	5	drug	drug	NOUN
admet-2043	1422	6	delivery	delivery	NOUN
admet-2043	1422	7	of	of	ADP
admet-2043	1422	8	macromolecules	macromolecule	NOUN
admet-2043	1422	9	across	across	ADP
admet-2043	1422	10	the	the	DET
admet-2043	1422	11	blood	blood	NOUN
admet-2043	1422	12	-	-	PUNCT
admet-2043	1422	13	brain	brain	NOUN
admet-2043	1422	14	barrier	barrier	NOUN
admet-2043	1422	15	.	.	PUNCT
admet-2043	1423	1	expert	expert	ADJ
admet-2043	1423	2	opinion	opinion	NOUN
admet-2043	1423	3	on	on	ADP
admet-2043	1423	4	drug	drug	NOUN
admet-2043	1423	5	delivery	delivery	NOUN
admet-2043	1423	6	17	17	NUM
admet-2043	1423	7	(	(	PUNCT
admet-2043	1423	8	2020	2020	NUM
admet-2043	1423	9	)	)	PUNCT
admet-2043	1423	10	23	23	NUM
admet-2043	1423	11	-	-	SYM
admet-2043	1423	12	32	32	NUM
admet-2043	1423	13	.	.	PUNCT
admet-2043	1424	1	https://doi.org/10.1080/17425247.2020.1698544	https://doi.org/10.1080/17425247.2020.1698544	PROPN
admet-2043	1424	2	.	.	PUNCT
admet-2043	1425	1	[	[	X
admet-2043	1425	2	170	170	NUM
admet-2043	1425	3	]	]	X
admet-2043	1425	4	e.	e.	PROPN
admet-2043	1425	5	soderstjerna	soderstjerna	PROPN
admet-2043	1425	6	,	,	PUNCT
admet-2043	1425	7	p.	p.	PROPN
admet-2043	1425	8	bauer	bauer	PROPN
admet-2043	1425	9	,	,	PUNCT
admet-2043	1425	10	t.	t.	PROPN
admet-2043	1425	11	cedervall	cedervall	PROPN
admet-2043	1425	12	,	,	PUNCT
admet-2043	1425	13	h.	h.	PROPN
admet-2043	1425	14	abdshill	abdshill	PROPN
admet-2043	1425	15	,	,	PUNCT
admet-2043	1425	16	f.	f.	PROPN
admet-2043	1425	17	johansson	johansson	PROPN
admet-2043	1425	18	,	,	PUNCT
admet-2043	1425	19	u.e	u.e	PROPN
admet-2043	1425	20	.	.	PROPN
admet-2043	1425	21	johansson	johansson	PROPN
admet-2043	1425	22	.	.	PUNCT
admet-2043	1426	1	silver	silver	NOUN
admet-2043	1426	2	and	and	CCONJ
admet-2043	1426	3	gold	gold	NOUN
admet-2043	1426	4	nanoparticles	nanoparticle	NOUN
admet-2043	1426	5	exposure	exposure	NOUN
admet-2043	1426	6	to	to	ADP
admet-2043	1426	7	in	in	ADV
admet-2043	1426	8	vitro	vitro	X
admet-2043	1426	9	cultured	cultured	ADJ
admet-2043	1426	10	retina	retina	NOUN
admet-2043	1426	11	--	--	PUNCT
admet-2043	1426	12	studies	study	NOUN
admet-2043	1426	13	on	on	ADP
admet-2043	1426	14	nanoparticle	nanoparticle	NOUN
admet-2043	1426	15	internalization	internalization	NOUN
admet-2043	1426	16	,	,	PUNCT
admet-2043	1426	17	apoptosis	apoptosis	NOUN
admet-2043	1426	18	,	,	PUNCT
admet-2043	1426	19	oxidative	oxidative	ADJ
admet-2043	1426	20	stress	stress	NOUN
admet-2043	1426	21	,	,	PUNCT
admet-2043	1426	22	glialand	glialand	NOUN
admet-2043	1426	23	microglial	microglial	ADJ
admet-2043	1426	24	activity	activity	NOUN
admet-2043	1426	25	.	.	PUNCT
admet-2043	1427	1	plos	plos	PROPN
admet-2043	1427	2	one	one	NUM
admet-2043	1427	3	9	9	NUM
admet-2043	1427	4	(	(	PUNCT
admet-2043	1427	5	2014	2014	NUM
admet-2043	1427	6	)	)	PUNCT
admet-2043	1427	7	e105359	e105359	NOUN
admet-2043	1427	8	.	.	PUNCT
admet-2043	1428	1	https://doi.org/10.1371/journal.pone.0105359	https://doi.org/10.1371/journal.pone.0105359	PROPN
admet-2043	1428	2	.	.	PUNCT
admet-2043	1429	1	[	[	X
admet-2043	1429	2	171	171	NUM
admet-2043	1429	3	]	]	X
admet-2043	1429	4	j.r	j.r	PROPN
admet-2043	1429	5	.	.	PROPN
admet-2043	1429	6	gee	gee	PROPN
admet-2043	1429	7	,	,	PUNCT
admet-2043	1429	8	j.n	j.n	PROPN
admet-2043	1429	9	.	.	PROPN
admet-2043	1429	10	keller	keller	PROPN
admet-2043	1429	11	.	.	PUNCT
admet-2043	1430	1	astrocytes	astrocyte	NOUN
admet-2043	1430	2	:	:	PUNCT
admet-2043	1430	3	regulation	regulation	NOUN
admet-2043	1430	4	of	of	ADP
admet-2043	1430	5	brain	brain	NOUN
admet-2043	1430	6	homeostasis	homeostasis	NOUN
admet-2043	1430	7	via	via	ADP
admet-2043	1430	8	apolipoprotein	apolipoprotein	ADJ
admet-2043	1430	9	e.	e.	PROPN
admet-2043	1430	10	the	the	DET
admet-2043	1430	11	international	international	ADJ
admet-2043	1430	12	journal	journal	PROPN
admet-2043	1430	13	of	of	ADP
admet-2043	1430	14	biochemistry	biochemistry	PROPN
admet-2043	1430	15	&	&	CCONJ
admet-2043	1430	16	cell	cell	NOUN
admet-2043	1430	17	biology	biology	NOUN
admet-2043	1430	18	37	37	NUM
admet-2043	1430	19	(	(	PUNCT
admet-2043	1430	20	2005	2005	NUM
admet-2043	1430	21	)	)	PUNCT
admet-2043	1430	22	1145	1145	NUM
admet-2043	1430	23	-	-	SYM
admet-2043	1430	24	1150	1150	NUM
admet-2043	1430	25	.	.	PUNCT
admet-2043	1431	1	https://doi.org/10.1016/j.biocel.2004.10.004	https://doi.org/10.1016/j.biocel.2004.10.004	NOUN
admet-2043	1431	2	.	.	PUNCT
admet-2043	1432	1	[	[	X
admet-2043	1432	2	172	172	NUM
admet-2043	1432	3	]	]	X
admet-2043	1432	4	m.k	m.k	PROPN
admet-2043	1432	5	.	.	PUNCT
admet-2043	1432	6	gottipati	gottipati	PROPN
admet-2043	1432	7	,	,	PUNCT
admet-2043	1432	8	a.r	a.r	PROPN
admet-2043	1432	9	.	.	PROPN
admet-2043	1432	10	d'amato	d'amato	PROPN
admet-2043	1432	11	,	,	PUNCT
admet-2043	1432	12	a.m.	a.m.	PROPN
admet-2043	1432	13	ziemba	ziemba	PROPN
admet-2043	1432	14	,	,	PUNCT
admet-2043	1432	15	p.g	p.g	PROPN
admet-2043	1432	16	.	.	PROPN
admet-2043	1432	17	popovich	popovich	PROPN
admet-2043	1432	18	,	,	PUNCT
admet-2043	1432	19	r.j	r.j	PROPN
admet-2043	1432	20	.	.	PROPN
admet-2043	1432	21	gilbert	gilbert	PROPN
admet-2043	1432	22	.	.	PUNCT
admet-2043	1433	1	tgfbeta3	tgfbeta3	PROPN
admet-2043	1433	2	is	be	AUX
admet-2043	1433	3	neuroprotective	neuroprotective	ADJ
admet-2043	1433	4	and	and	CCONJ
admet-2043	1433	5	alleviates	alleviate	VERB
admet-2043	1433	6	the	the	DET
admet-2043	1433	7	neurotoxic	neurotoxic	ADJ
admet-2043	1433	8	response	response	NOUN
admet-2043	1433	9	induced	induce	VERB
admet-2043	1433	10	by	by	ADP
admet-2043	1433	11	aligned	aligned	ADJ
admet-2043	1433	12	poly	poly	ADJ
admet-2043	1433	13	-	-	PUNCT
admet-2043	1433	14	l	l	NOUN
admet-2043	1433	15	-	-	ADJ
admet-2043	1433	16	lactic	lactic	ADJ
admet-2043	1433	17	acid	acid	NOUN
admet-2043	1433	18	fibers	fiber	NOUN
admet-2043	1433	19	on	on	ADP
admet-2043	1433	20	naive	naive	ADJ
admet-2043	1433	21	and	and	CCONJ
admet-2043	1433	22	activated	activated	ADJ
admet-2043	1433	23	primary	primary	ADJ
admet-2043	1433	24	astrocytes	astrocyte	NOUN
admet-2043	1433	25	.	.	PUNCT
admet-2043	1434	1	acta	acta	PROPN
admet-2043	1434	2	biomaterialia	biomaterialia	PROPN
admet-2043	1434	3	117	117	NUM
admet-2043	1434	4	(	(	PUNCT
admet-2043	1434	5	2020	2020	NUM
admet-2043	1434	6	)	)	PUNCT
admet-2043	1434	7	273	273	NUM
admet-2043	1434	8	-	-	SYM
admet-2043	1434	9	282	282	NUM
admet-2043	1434	10	.	.	PUNCT
admet-2043	1434	11	https://doi.org/10.1016/j.actbio.2020.09.057	https://doi.org/10.1016/j.actbio.2020.09.057	NOUN
admet-2043	1434	12	.	.	PUNCT
admet-2043	1435	1	[	[	X
admet-2043	1435	2	173	173	NUM
admet-2043	1435	3	]	]	X
admet-2043	1435	4	d.	d.	PROPN
admet-2043	1435	5	soulet	soulet	PROPN
admet-2043	1435	6	,	,	PUNCT
admet-2043	1435	7	s.	s.	PROPN
admet-2043	1435	8	rivest	rivest	VERB
admet-2043	1435	9	.	.	PUNCT
admet-2043	1436	1	polyamines	polyamine	NOUN
admet-2043	1436	2	play	play	VERB
admet-2043	1436	3	a	a	DET
admet-2043	1436	4	critical	critical	ADJ
admet-2043	1436	5	role	role	NOUN
admet-2043	1436	6	in	in	ADP
admet-2043	1436	7	the	the	DET
admet-2043	1436	8	control	control	NOUN
admet-2043	1436	9	of	of	ADP
admet-2043	1436	10	the	the	DET
admet-2043	1436	11	innate	innate	ADJ
admet-2043	1436	12	immune	immune	ADJ
admet-2043	1436	13	response	response	NOUN
admet-2043	1436	14	in	in	ADP
admet-2043	1436	15	the	the	DET
admet-2043	1436	16	mouse	mouse	NOUN
admet-2043	1436	17	central	central	ADJ
admet-2043	1436	18	nervous	nervous	ADJ
admet-2043	1436	19	system	system	NOUN
admet-2043	1436	20	.	.	PUNCT
admet-2043	1437	1	journal	journal	NOUN
admet-2043	1437	2	of	of	ADP
admet-2043	1437	3	cell	cell	NOUN
admet-2043	1437	4	biology	biology	NOUN
admet-2043	1437	5	162	162	NUM
admet-2043	1437	6	(	(	PUNCT
admet-2043	1437	7	2003	2003	NUM
admet-2043	1437	8	)	)	PUNCT
admet-2043	1437	9	257	257	NUM
admet-2043	1437	10	-	-	SYM
admet-2043	1437	11	268	268	NUM
admet-2043	1437	12	.	.	PUNCT
admet-2043	1438	1	https://doi.org/10.1083/jcb.200301097	https://doi.org/10.1083/jcb.200301097	PROPN
admet-2043	1438	2	.	.	PUNCT
admet-2043	1439	1	[	[	X
admet-2043	1439	2	174	174	NUM
admet-2043	1439	3	]	]	X
admet-2043	1439	4	s.a	s.a	PROPN
admet-2043	1439	5	.	.	PROPN
admet-2043	1439	6	abdelrahman	abdelrahman	PROPN
admet-2043	1439	7	,	,	PUNCT
admet-2043	1439	8	a.s	a.s	PROPN
admet-2043	1439	9	.	.	PROPN
admet-2043	1439	10	el	el	PROPN
admet-2043	1439	11	-	-	PROPN
admet-2043	1439	12	shal	shal	PROPN
admet-2043	1439	13	,	,	PUNCT
admet-2043	1439	14	a.a	a.a	PROPN
admet-2043	1439	15	.	.	PROPN
admet-2043	1439	16	abdelrahman	abdelrahman	PROPN
admet-2043	1439	17	,	,	PUNCT
admet-2043	1439	18	e.z.h	e.z.h	PROPN
admet-2043	1439	19	.	.	PROPN
admet-2043	1439	20	saleh	saleh	PROPN
admet-2043	1439	21	,	,	PUNCT
admet-2043	1439	22	a.a	a.a	PROPN
admet-2043	1439	23	.	.	PROPN
admet-2043	1439	24	mahmoud	mahmoud	PROPN
admet-2043	1439	25	.	.	PUNCT
admet-2043	1439	26	neuroprotective	neuroprotective	ADJ
admet-2043	1439	27	effects	effect	NOUN
admet-2043	1439	28	of	of	ADP
admet-2043	1439	29	quercetin	quercetin	NOUN
admet-2043	1439	30	on	on	ADP
admet-2043	1439	31	the	the	DET
admet-2043	1439	32	cerebellum	cerebellum	NOUN
admet-2043	1439	33	of	of	ADP
admet-2043	1439	34	zinc	zinc	NOUN
admet-2043	1439	35	oxide	oxide	NOUN
admet-2043	1439	36	nanoparticles	nanoparticle	NOUN
admet-2043	1439	37	(	(	PUNCT
admet-2043	1439	38	znonps)-exposed	znonps)-expose	VERB
admet-2043	1439	39	rats	rat	NOUN
admet-2043	1439	40	.	.	PUNCT
admet-2043	1440	1	tissue	tissue	NOUN
admet-2043	1440	2	barriers	barrier	NOUN
admet-2043	1440	3	11	11	NUM
admet-2043	1440	4	(	(	PUNCT
admet-2043	1440	5	2023	2023	NUM
admet-2043	1440	6	)	)	PUNCT
admet-2043	1440	7	2115273	2115273	NUM
admet-2043	1440	8	.	.	PUNCT
admet-2043	1441	1	https://doi.org/10.1080/21688370.2022.2115273	https://doi.org/10.1080/21688370.2022.2115273	X
admet-2043	1441	2	.	.	PUNCT
admet-2043	1441	3	https://doi.org/https:/www.ncbi.nlm.nih.gov/pubmed/10565819	https://doi.org/https:/www.ncbi.nlm.nih.gov/pubmed/10565819	ADJ
admet-2043	1441	4	https://doi.org/10.1152/ajpheart.1990.259.1.h162	https://doi.org/10.1152/ajpheart.1990.259.1.h162	NOUN
admet-2043	1441	5	https://doi.org/10.1080/10611860400015936	https://doi.org/10.1080/10611860400015936	NOUN
admet-2043	1441	6	https://doi.org/10.1166/jnn.2006.441	https://doi.org/10.1166/jnn.2006.441	PROPN
admet-2043	1441	7	https://doi.org/10.1021/acsbiomaterials.0c00743	https://doi.org/10.1021/acsbiomaterials.0c00743	PROPN
admet-2043	1441	8	https://doi.org/10.1016/j.maturitas.2011.12.015	https://doi.org/10.1016/j.maturitas.2011.12.015	PROPN
admet-2043	1441	9	https://doi.org/10.1016/j.ejmech.2019.01.007	https://doi.org/10.1016/j.ejmech.2019.01.007	VERB
admet-2043	1441	10	https://doi.org/10.1016/j.ijpharm.2018.11.035	https://doi.org/10.1016/j.ijpharm.2018.11.035	PROPN
admet-2043	1441	11	https://doi.org/10.3390/pr8030355	https://doi.org/10.3390/pr8030355	PROPN
admet-2043	1441	12	https://doi.org/10.1016/j.addr.2012.08.005	https://doi.org/10.1016/j.addr.2012.08.005	PROPN
admet-2043	1441	13	https://doi.org/10.1080/17425247.2020.1698544	https://doi.org/10.1080/17425247.2020.1698544	PROPN
admet-2043	1441	14	https://doi.org/10.1371/journal.pone.0105359	https://doi.org/10.1371/journal.pone.0105359	PROPN
admet-2043	1441	15	https://doi.org/10.1016/j.biocel.2004.10.004	https://doi.org/10.1016/j.biocel.2004.10.004	PROPN
admet-2043	1441	16	https://doi.org/10.1016/j.actbio.2020.09.057	https://doi.org/10.1016/j.actbio.2020.09.057	NOUN
admet-2043	1441	17	https://doi.org/10.1083/jcb.200301097	https://doi.org/10.1083/jcb.200301097	PROPN
admet-2043	1442	1	https://doi.org/10.1080/21688370.2022.2115273	https://doi.org/10.1080/21688370.2022.2115273	PROPN
admet-2043	1442	2	admet	admet	PROPN
admet-2043	1442	3	&	&	CCONJ
admet-2043	1442	4	dmpk	dmpk	PROPN
admet-2043	1442	5	12(1	12(1	PROPN
admet-2043	1442	6	)	)	PUNCT
admet-2043	1442	7	(	(	PUNCT
admet-2043	1442	8	2024	2024	NUM
admet-2043	1442	9	)	)	PUNCT
admet-2043	1442	10	63	63	NUM
admet-2043	1442	11	-	-	SYM
admet-2043	1442	12	105	105	NUM
admet-2043	1442	13	nanomaterials	nanomaterial	NOUN
admet-2043	1442	14	as	as	ADP
admet-2043	1442	15	drug	drug	NOUN
admet-2043	1442	16	delivery	delivery	NOUN
admet-2043	1442	17	agents	agent	NOUN
admet-2043	1442	18	for	for	ADP
admet-2043	1442	19	overcoming	overcome	VERB
admet-2043	1442	20	bbb	bbb	PROPN
admet-2043	1442	21	doi	doi	NOUN
admet-2043	1442	22	:	:	PUNCT
admet-2043	1442	23	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1442	24	103	103	NUM
admet-2043	1442	25	[	[	X
admet-2043	1442	26	175	175	NUM
admet-2043	1442	27	]	]	X
admet-2043	1442	28	k.f	k.f	PROPN
admet-2043	1442	29	.	.	PROPN
admet-2043	1442	30	bing	bing	PROPN
admet-2043	1442	31	,	,	PUNCT
admet-2043	1442	32	g.p	g.p	PROPN
admet-2043	1442	33	.	.	PROPN
admet-2043	1442	34	howles	howle	NOUN
admet-2043	1442	35	,	,	PUNCT
admet-2043	1442	36	y.	y.	PROPN
admet-2043	1442	37	qi	qi	PROPN
admet-2043	1442	38	,	,	PUNCT
admet-2043	1442	39	m.l	m.l	PROPN
admet-2043	1442	40	.	.	PROPN
admet-2043	1442	41	palmeri	palmeri	PROPN
admet-2043	1442	42	,	,	PUNCT
admet-2043	1442	43	k.r	k.r	PROPN
admet-2043	1442	44	.	.	PROPN
admet-2043	1442	45	nightingale	nightingale	PROPN
admet-2043	1442	46	.	.	PUNCT
admet-2043	1443	1	blood	blood	NOUN
admet-2043	1443	2	-	-	PUNCT
admet-2043	1443	3	brain	brain	NOUN
admet-2043	1443	4	barrier	barrier	NOUN
admet-2043	1443	5	(	(	PUNCT
admet-2043	1443	6	bbb	bbb	NOUN
admet-2043	1443	7	)	)	PUNCT
admet-2043	1443	8	disruption	disruption	NOUN
admet-2043	1443	9	using	use	VERB
admet-2043	1443	10	a	a	DET
admet-2043	1443	11	diagnostic	diagnostic	ADJ
admet-2043	1443	12	ultrasound	ultrasound	NOUN
admet-2043	1443	13	scanner	scanner	NOUN
admet-2043	1443	14	and	and	CCONJ
admet-2043	1443	15	definity	definity	NOUN
admet-2043	1443	16	in	in	ADP
admet-2043	1443	17	mice	mouse	NOUN
admet-2043	1443	18	.	.	PUNCT
admet-2043	1444	1	ultrasound	ultrasound	NOUN
admet-2043	1444	2	in	in	ADP
admet-2043	1444	3	medicine	medicine	NOUN
admet-2043	1444	4	and	and	CCONJ
admet-2043	1444	5	biology	biology	NOUN
admet-2043	1444	6	35	35	NUM
admet-2043	1444	7	(	(	PUNCT
admet-2043	1444	8	2009	2009	NUM
admet-2043	1444	9	)	)	PUNCT
admet-2043	1444	10	1298	1298	NUM
admet-2043	1444	11	-	-	SYM
admet-2043	1444	12	1308	1308	NUM
admet-2043	1444	13	.	.	PUNCT
admet-2043	1445	1	https://doi.org/10.1016/j.ultrasmedbio.2009.03.012	https://doi.org/10.1016/j.ultrasmedbio.2009.03.012	NOUN
admet-2043	1445	2	.	.	PUNCT
admet-2043	1446	1	[	[	X
admet-2043	1446	2	176	176	NUM
admet-2043	1446	3	]	]	X
admet-2043	1446	4	c.	c.	PROPN
admet-2043	1446	5	tapeinos	tapeinos	PROPN
admet-2043	1446	6	,	,	PUNCT
admet-2043	1446	7	m.	m.	NOUN
admet-2043	1446	8	battaglini	battaglini	PROPN
admet-2043	1446	9	,	,	PUNCT
admet-2043	1446	10	g.	g.	PROPN
admet-2043	1446	11	ciofani	ciofani	PROPN
admet-2043	1446	12	.	.	PUNCT
admet-2043	1447	1	advances	advance	NOUN
admet-2043	1447	2	in	in	ADP
admet-2043	1447	3	the	the	DET
admet-2043	1447	4	design	design	NOUN
admet-2043	1447	5	of	of	ADP
admet-2043	1447	6	solid	solid	ADJ
admet-2043	1447	7	lipid	lipid	NOUN
admet-2043	1447	8	nanoparticles	nanoparticle	NOUN
admet-2043	1447	9	and	and	CCONJ
admet-2043	1447	10	nanostructured	nanostructure	VERB
admet-2043	1447	11	lipid	lipid	NOUN
admet-2043	1447	12	carriers	carrier	NOUN
admet-2043	1447	13	for	for	ADP
admet-2043	1447	14	targeting	target	VERB
admet-2043	1447	15	brain	brain	NOUN
admet-2043	1447	16	diseases	disease	NOUN
admet-2043	1447	17	.	.	PUNCT
admet-2043	1448	1	journal	journal	NOUN
admet-2043	1448	2	of	of	ADP
admet-2043	1448	3	controlled	control	VERB
admet-2043	1448	4	release	release	NOUN
admet-2043	1448	5	264	264	NUM
admet-2043	1448	6	(	(	PUNCT
admet-2043	1448	7	2017	2017	NUM
admet-2043	1448	8	)	)	PUNCT
admet-2043	1448	9	306	306	NUM
admet-2043	1448	10	-	-	SYM
admet-2043	1448	11	332	332	NUM
admet-2043	1448	12	.	.	PUNCT
admet-2043	1449	1	https://doi.org/10.1016/j.jconrel.2017.08.033	https://doi.org/10.1016/j.jconrel.2017.08.033	ADJ
admet-2043	1449	2	.	.	PUNCT
admet-2043	1450	1	[	[	X
admet-2043	1450	2	177	177	NUM
admet-2043	1450	3	]	]	SYM
admet-2043	1450	4	p.m.	p.m.	NOUN
admet-2043	1450	5	gosselin	gosselin	PROPN
admet-2043	1450	6	,	,	PUNCT
admet-2043	1450	7	r.	r.	PROPN
admet-2043	1450	8	thibert	thibert	PROPN
admet-2043	1450	9	,	,	PUNCT
admet-2043	1450	10	m.	m.	NOUN
admet-2043	1450	11	preda	preda	PROPN
admet-2043	1450	12	,	,	PUNCT
admet-2043	1450	13	j.n	j.n	PROPN
admet-2043	1450	14	.	.	PROPN
admet-2043	1450	15	mcmullen	mcmullen	PROPN
admet-2043	1450	16	.	.	PUNCT
admet-2043	1451	1	polymorphic	polymorphic	ADJ
admet-2043	1451	2	properties	property	NOUN
admet-2043	1451	3	of	of	ADP
admet-2043	1451	4	micronized	micronized	ADJ
admet-2043	1451	5	carbamazepine	carbamazepine	NOUN
admet-2043	1451	6	produced	produce	VERB
admet-2043	1451	7	by	by	ADP
admet-2043	1451	8	ress	ress	PROPN
admet-2043	1451	9	.	.	PUNCT
admet-2043	1452	1	international	international	ADJ
admet-2043	1452	2	journal	journal	PROPN
admet-2043	1452	3	of	of	ADP
admet-2043	1452	4	pharmaceutics	pharmaceutic	NOUN
admet-2043	1452	5	252	252	NUM
admet-2043	1452	6	(	(	PUNCT
admet-2043	1452	7	2003	2003	NUM
admet-2043	1452	8	)	)	PUNCT
admet-2043	1452	9	225	225	NUM
admet-2043	1452	10	-	-	SYM
admet-2043	1452	11	233	233	NUM
admet-2043	1452	12	.	.	PUNCT
admet-2043	1453	1	https://doi.org/10.1016/s0378-5173(02)00649-x	https://doi.org/10.1016/s0378-5173(02)00649-x	NOUN
admet-2043	1453	2	.	.	PUNCT
admet-2043	1454	1	[	[	X
admet-2043	1454	2	178	178	NUM
admet-2043	1454	3	]	]	X
admet-2043	1454	4	m.k	m.k	PROPN
admet-2043	1454	5	.	.	PROPN
admet-2043	1454	6	satapathy	satapathy	ADJ
admet-2043	1454	7	,	,	PUNCT
admet-2043	1454	8	t.l	t.l	PROPN
admet-2043	1454	9	.	.	NOUN
admet-2043	1454	10	yen	yen	PROPN
admet-2043	1454	11	,	,	PUNCT
admet-2043	1454	12	j.s	j.s	PROPN
admet-2043	1454	13	.	.	PROPN
admet-2043	1454	14	jan	jan	PROPN
admet-2043	1454	15	,	,	PUNCT
admet-2043	1454	16	r.d	r.d	PROPN
admet-2043	1454	17	.	.	PROPN
admet-2043	1454	18	tang	tang	PROPN
admet-2043	1454	19	,	,	PUNCT
admet-2043	1454	20	j.y	j.y	PROPN
admet-2043	1454	21	.	.	PROPN
admet-2043	1454	22	wang	wang	PROPN
admet-2043	1454	23	,	,	PUNCT
admet-2043	1454	24	r.	r.	PROPN
admet-2043	1454	25	taliyan	taliyan	PROPN
admet-2043	1454	26	,	,	PUNCT
admet-2043	1454	27	c.h	c.h	PROPN
admet-2043	1454	28	.	.	PROPN
admet-2043	1454	29	yang	yang	PROPN
admet-2043	1454	30	.	.	PUNCT
admet-2043	1455	1	solid	solid	ADJ
admet-2043	1455	2	lipid	lipid	ADJ
admet-2043	1455	3	nanoparticles	nanoparticle	NOUN
admet-2043	1455	4	(	(	PUNCT
admet-2043	1455	5	slns	slns	NOUN
admet-2043	1455	6	):	):	PUNCT
admet-2043	1455	7	an	an	DET
admet-2043	1455	8	advanced	advanced	ADJ
admet-2043	1455	9	drug	drug	NOUN
admet-2043	1455	10	delivery	delivery	NOUN
admet-2043	1455	11	system	system	NOUN
admet-2043	1455	12	targeting	target	VERB
admet-2043	1455	13	brain	brain	NOUN
admet-2043	1455	14	through	through	ADP
admet-2043	1455	15	bbb	bbb	PROPN
admet-2043	1455	16	.	.	PUNCT
admet-2043	1456	1	pharmaceutics	pharmaceutic	NOUN
admet-2043	1456	2	13	13	NUM
admet-2043	1456	3	(	(	PUNCT
admet-2043	1456	4	2021	2021	NUM
admet-2043	1456	5	)	)	PUNCT
admet-2043	1456	6	1183	1183	NUM
admet-2043	1456	7	.	.	PUNCT
admet-2043	1457	1	https://doi.org/10.3390/pharmaceutics13081183	https://doi.org/10.3390/pharmaceutics13081183	PROPN
admet-2043	1457	2	.	.	PUNCT
admet-2043	1458	1	[	[	X
admet-2043	1458	2	179	179	NUM
admet-2043	1458	3	]	]	X
admet-2043	1458	4	a.	a.	PROPN
admet-2043	1458	5	o'donnell	o'donnell	PROPN
admet-2043	1458	6	,	,	PUNCT
admet-2043	1458	7	a.	a.	PROPN
admet-2043	1458	8	moollan	moollan	PROPN
admet-2043	1458	9	,	,	PUNCT
admet-2043	1458	10	s.	s.	PROPN
admet-2043	1458	11	baneham	baneham	PROPN
admet-2043	1458	12	,	,	PUNCT
admet-2043	1458	13	m.	m.	NOUN
admet-2043	1458	14	ozgul	ozgul	PROPN
admet-2043	1458	15	,	,	PUNCT
admet-2043	1458	16	r.m	r.m	PROPN
admet-2043	1458	17	.	.	PROPN
admet-2043	1458	18	pabari	pabari	PROPN
admet-2043	1458	19	,	,	PUNCT
admet-2043	1458	20	d.	d.	PROPN
admet-2043	1458	21	cox	cox	PROPN
admet-2043	1458	22	,	,	PUNCT
admet-2043	1458	23	b.p	b.p	PROPN
admet-2043	1458	24	.	.	PROPN
admet-2043	1458	25	kirby	kirby	PROPN
admet-2043	1458	26	,	,	PUNCT
admet-2043	1458	27	z.	z.	PROPN
admet-2043	1458	28	ramtoola	ramtoola	PROPN
admet-2043	1458	29	.	.	PUNCT
admet-2043	1459	1	intranasal	intranasal	NOUN
admet-2043	1459	2	and	and	CCONJ
admet-2043	1459	3	intravenous	intravenous	ADJ
admet-2043	1459	4	administration	administration	NOUN
admet-2043	1459	5	of	of	ADP
admet-2043	1459	6	octa	octa	NOUN
admet-2043	1459	7	-	-	PUNCT
admet-2043	1459	8	arginine	arginine	NOUN
admet-2043	1459	9	modified	modify	VERB
admet-2043	1459	10	poly(lactic	poly(lactic	PROPN
admet-2043	1459	11	-	-	PUNCT
admet-2043	1459	12	co	co	NOUN
admet-2043	1459	13	-	-	ADJ
admet-2043	1459	14	glycolic	glycolic	ADJ
admet-2043	1459	15	acid	acid	NOUN
admet-2043	1459	16	)	)	PUNCT
admet-2043	1459	17	nanoparticles	nanoparticle	NOUN
admet-2043	1459	18	facilitates	facilitate	VERB
admet-2043	1459	19	central	central	ADJ
admet-2043	1459	20	nervous	nervous	ADJ
admet-2043	1459	21	system	system	NOUN
admet-2043	1459	22	delivery	delivery	NOUN
admet-2043	1459	23	of	of	ADP
admet-2043	1459	24	loperamide	loperamide	NOUN
admet-2043	1459	25	.	.	PUNCT
admet-2043	1460	1	journal	journal	PROPN
admet-2043	1460	2	of	of	ADP
admet-2043	1460	3	pharmacy	pharmacy	NOUN
admet-2043	1460	4	and	and	CCONJ
admet-2043	1460	5	pharmacology	pharmacology	NOUN
admet-2043	1460	6	67	67	NUM
admet-2043	1460	7	(	(	PUNCT
admet-2043	1460	8	2015	2015	NUM
admet-2043	1460	9	)	)	PUNCT
admet-2043	1460	10	525	525	NUM
admet-2043	1460	11	-	-	SYM
admet-2043	1460	12	536	536	NUM
admet-2043	1460	13	.	.	PUNCT
admet-2043	1461	1	https://doi.org/10.1111/jphp.12347	https://doi.org/10.1111/jphp.12347	ADJ
admet-2043	1461	2	.	.	PUNCT
admet-2043	1462	1	[	[	X
admet-2043	1462	2	180	180	NUM
admet-2043	1462	3	]	]	X
admet-2043	1462	4	t.b	t.b	PROPN
admet-2043	1462	5	.	.	PROPN
admet-2043	1462	6	devkar	devkar	PROPN
admet-2043	1462	7	,	,	PUNCT
admet-2043	1462	8	a.r	a.r	PROPN
admet-2043	1462	9	.	.	PROPN
admet-2043	1462	10	tekade	tekade	PROPN
admet-2043	1462	11	,	,	PUNCT
admet-2043	1462	12	k.r	k.r	PROPN
admet-2043	1462	13	.	.	PROPN
admet-2043	1462	14	khandelwal	khandelwal	PROPN
admet-2043	1462	15	.	.	PUNCT
admet-2043	1463	1	surface	surface	PROPN
admet-2043	1463	2	engineered	engineer	VERB
admet-2043	1463	3	nanostructured	nanostructure	VERB
admet-2043	1463	4	lipid	lipid	NOUN
admet-2043	1463	5	carriers	carrier	NOUN
admet-2043	1463	6	for	for	ADP
admet-2043	1463	7	efficient	efficient	ADJ
admet-2043	1463	8	nose	nose	NOUN
admet-2043	1463	9	to	to	ADP
admet-2043	1463	10	brain	brain	NOUN
admet-2043	1463	11	delivery	delivery	NOUN
admet-2043	1463	12	of	of	ADP
admet-2043	1463	13	ondansetron	ondansetron	PROPN
admet-2043	1463	14	hcl	hcl	PROPN
admet-2043	1463	15	using	use	VERB
admet-2043	1463	16	delonix	delonix	NOUN
admet-2043	1463	17	regia	regia	NOUN
admet-2043	1463	18	gum	gum	NOUN
admet-2043	1463	19	as	as	ADP
admet-2043	1463	20	a	a	DET
admet-2043	1463	21	natural	natural	ADJ
admet-2043	1463	22	mucoadhesive	mucoadhesive	ADJ
admet-2043	1463	23	polymer	polymer	NOUN
admet-2043	1463	24	.	.	PUNCT
admet-2043	1463	25	colloids	colloid	NOUN
admet-2043	1463	26	and	and	CCONJ
admet-2043	1463	27	surfaces	surface	NOUN
admet-2043	1463	28	b	b	NUM
admet-2043	1463	29	:	:	PUNCT
admet-2043	1463	30	biointerfaces	biointerface	NOUN
admet-2043	1463	31	122	122	NUM
admet-2043	1463	32	(	(	PUNCT
admet-2043	1463	33	2014	2014	NUM
admet-2043	1463	34	)	)	PUNCT
admet-2043	1463	35	143	143	NUM
admet-2043	1463	36	-	-	SYM
admet-2043	1463	37	150	150	NUM
admet-2043	1463	38	.	.	PUNCT
admet-2043	1463	39	https://doi.org/10.1016/j.colsurfb.2014.06.037	https://doi.org/10.1016/j.colsurfb.2014.06.037	NOUN
admet-2043	1463	40	.	.	PUNCT
admet-2043	1464	1	[	[	X
admet-2043	1464	2	181	181	NUM
admet-2043	1464	3	]	]	X
admet-2043	1464	4	c.h	c.h	PROPN
admet-2043	1464	5	.	.	PROPN
admet-2043	1464	6	choi	choi	PROPN
admet-2043	1464	7	,	,	PUNCT
admet-2043	1464	8	j.e	j.e	PROPN
admet-2043	1464	9	.	.	PROPN
admet-2043	1464	10	zuckerman	zuckerman	PROPN
admet-2043	1464	11	,	,	PUNCT
admet-2043	1464	12	p.	p.	PROPN
admet-2043	1464	13	webster	webster	PROPN
admet-2043	1464	14	,	,	PUNCT
admet-2043	1464	15	m.e	m.e	PROPN
admet-2043	1464	16	.	.	PROPN
admet-2043	1464	17	davis	davis	PROPN
admet-2043	1464	18	.	.	PUNCT
admet-2043	1465	1	targeting	target	VERB
admet-2043	1465	2	kidney	kidney	NOUN
admet-2043	1465	3	mesangium	mesangium	NOUN
admet-2043	1465	4	by	by	ADP
admet-2043	1465	5	nanoparticles	nanoparticle	NOUN
admet-2043	1465	6	of	of	ADP
admet-2043	1465	7	defined	define	VERB
admet-2043	1465	8	size	size	NOUN
admet-2043	1465	9	.	.	PUNCT
admet-2043	1466	1	proceedings	proceeding	NOUN
admet-2043	1466	2	of	of	ADP
admet-2043	1466	3	the	the	DET
admet-2043	1466	4	national	national	PROPN
admet-2043	1466	5	academy	academy	PROPN
admet-2043	1466	6	of	of	ADP
admet-2043	1466	7	sciences	sciences	PROPN
admet-2043	1466	8	of	of	ADP
admet-2043	1466	9	the	the	DET
admet-2043	1466	10	united	united	PROPN
admet-2043	1466	11	states	states	PROPN
admet-2043	1466	12	of	of	ADP
admet-2043	1466	13	america	america	PROPN
admet-2043	1466	14	108	108	NUM
admet-2043	1466	15	(	(	PUNCT
admet-2043	1466	16	2011	2011	NUM
admet-2043	1466	17	)	)	PUNCT
admet-2043	1466	18	6656	6656	NUM
admet-2043	1466	19	-	-	SYM
admet-2043	1466	20	6661	6661	NUM
admet-2043	1466	21	.	.	PUNCT
admet-2043	1467	1	https://doi.org/10.1073/pnas.1103573108	https://doi.org/10.1073/pnas.1103573108	NOUN
admet-2043	1467	2	.	.	PUNCT
admet-2043	1468	1	[	[	X
admet-2043	1468	2	182	182	NUM
admet-2043	1468	3	]	]	PUNCT
admet-2043	1468	4	j.	j.	PROPN
admet-2043	1468	5	duan	duan	PROPN
admet-2043	1468	6	,	,	PUNCT
admet-2043	1468	7	y.	y.	PROPN
admet-2043	1468	8	yu	yu	PROPN
admet-2043	1468	9	,	,	PUNCT
admet-2043	1468	10	y.	y.	PROPN
admet-2043	1468	11	li	li	PROPN
admet-2043	1468	12	,	,	PUNCT
admet-2043	1468	13	y.	y.	PROPN
admet-2043	1468	14	yu	yu	PROPN
admet-2043	1468	15	,	,	PUNCT
admet-2043	1468	16	z.	z.	PROPN
admet-2043	1468	17	sun	sun	PROPN
admet-2043	1468	18	.	.	PUNCT
admet-2043	1469	1	cardiovascular	cardiovascular	ADJ
admet-2043	1469	2	toxicity	toxicity	NOUN
admet-2043	1469	3	evaluation	evaluation	NOUN
admet-2043	1469	4	of	of	ADP
admet-2043	1469	5	silica	silica	NOUN
admet-2043	1469	6	nanoparticles	nanoparticle	NOUN
admet-2043	1469	7	in	in	ADP
admet-2043	1469	8	endothelial	endothelial	ADJ
admet-2043	1469	9	cells	cell	NOUN
admet-2043	1469	10	and	and	CCONJ
admet-2043	1469	11	zebrafish	zebrafish	ADJ
admet-2043	1469	12	model	model	NOUN
admet-2043	1469	13	.	.	PUNCT
admet-2043	1470	1	biomaterials	biomaterial	NOUN
admet-2043	1470	2	34	34	NUM
admet-2043	1470	3	(	(	PUNCT
admet-2043	1470	4	2013	2013	NUM
admet-2043	1470	5	)	)	PUNCT
admet-2043	1470	6	5853	5853	NUM
admet-2043	1470	7	-	-	SYM
admet-2043	1470	8	5862	5862	NUM
admet-2043	1470	9	.	.	PUNCT
admet-2043	1471	1	https://doi.org/10.1016/j.biomaterials.2013.04.032	https://doi.org/10.1016/j.biomaterials.2013.04.032	NOUN
admet-2043	1471	2	.	.	PUNCT
admet-2043	1472	1	[	[	X
admet-2043	1472	2	183	183	NUM
admet-2043	1472	3	]	]	PUNCT
admet-2043	1472	4	e.	e.	PROPN
admet-2043	1472	5	barbu	barbu	PROPN
admet-2043	1472	6	,	,	PUNCT
admet-2043	1472	7	e.	e.	PROPN
admet-2043	1472	8	molnar	molnar	PROPN
admet-2043	1472	9	,	,	PUNCT
admet-2043	1472	10	j.	j.	PROPN
admet-2043	1472	11	tsibouklis	tsibouklis	PROPN
admet-2043	1472	12	,	,	PUNCT
admet-2043	1472	13	d.c	d.c	PROPN
admet-2043	1472	14	.	.	PROPN
admet-2043	1472	15	gorecki	gorecki	PROPN
admet-2043	1472	16	.	.	PUNCT
admet-2043	1473	1	the	the	DET
admet-2043	1473	2	potential	potential	NOUN
admet-2043	1473	3	for	for	ADP
admet-2043	1473	4	nanoparticle	nanoparticle	NOUN
admet-2043	1473	5	-	-	PUNCT
admet-2043	1473	6	based	base	VERB
admet-2043	1473	7	drug	drug	NOUN
admet-2043	1473	8	delivery	delivery	NOUN
admet-2043	1473	9	to	to	ADP
admet-2043	1473	10	the	the	DET
admet-2043	1473	11	brain	brain	NOUN
admet-2043	1473	12	:	:	PUNCT
admet-2043	1473	13	overcoming	overcome	VERB
admet-2043	1473	14	the	the	DET
admet-2043	1473	15	blood	blood	NOUN
admet-2043	1473	16	-	-	PUNCT
admet-2043	1473	17	brain	brain	NOUN
admet-2043	1473	18	barrier	barrier	NOUN
admet-2043	1473	19	.	.	PUNCT
admet-2043	1474	1	expert	expert	ADJ
admet-2043	1474	2	opinion	opinion	NOUN
admet-2043	1474	3	on	on	ADP
admet-2043	1474	4	drug	drug	NOUN
admet-2043	1474	5	delivery	delivery	NOUN
admet-2043	1474	6	6	6	NUM
admet-2043	1474	7	(	(	PUNCT
admet-2043	1474	8	2009	2009	NUM
admet-2043	1474	9	)	)	PUNCT
admet-2043	1474	10	553565	553565	NUM
admet-2043	1474	11	.	.	PUNCT
admet-2043	1475	1	https://doi.org/10.1517/17425240902939143	https://doi.org/10.1517/17425240902939143	INTJ
admet-2043	1475	2	.	.	PUNCT
admet-2043	1476	1	[	[	X
admet-2043	1476	2	184	184	X
admet-2043	1476	3	]	]	PUNCT
admet-2043	1476	4	j.	j.	PROPN
admet-2043	1476	5	kreuter	kreuter	PROPN
admet-2043	1476	6	,	,	PUNCT
admet-2043	1476	7	s.	s.	PROPN
admet-2043	1476	8	gelperina	gelperina	PROPN
admet-2043	1476	9	.	.	PUNCT
admet-2043	1477	1	use	use	NOUN
admet-2043	1477	2	of	of	ADP
admet-2043	1477	3	nanoparticles	nanoparticle	NOUN
admet-2043	1477	4	for	for	ADP
admet-2043	1477	5	cerebral	cerebral	ADJ
admet-2043	1477	6	cancer	cancer	NOUN
admet-2043	1477	7	.	.	PUNCT
admet-2043	1478	1	tumori	tumori	PROPN
admet-2043	1478	2	journal	journal	PROPN
admet-2043	1478	3	94	94	NUM
admet-2043	1478	4	(	(	PUNCT
admet-2043	1478	5	2008	2008	NUM
admet-2043	1478	6	)	)	PUNCT
admet-2043	1478	7	271277	271277	NUM
admet-2043	1478	8	.	.	PUNCT
admet-2043	1479	1	https://doi.org/10.1177/030089160809400220	https://doi.org/10.1177/030089160809400220	VERB
admet-2043	1479	2	.	.	PUNCT
admet-2043	1480	1	[	[	X
admet-2043	1480	2	185	185	NUM
admet-2043	1480	3	]	]	PUNCT
admet-2043	1480	4	p.	p.	NOUN
admet-2043	1480	5	simard	simard	PROPN
admet-2043	1480	6	,	,	PUNCT
admet-2043	1480	7	j.c	j.c	PROPN
admet-2043	1480	8	.	.	PROPN
admet-2043	1480	9	leroux	leroux	PROPN
admet-2043	1480	10	.	.	PUNCT
admet-2043	1481	1	in	in	ADP
admet-2043	1481	2	vivo	vivo	ADJ
admet-2043	1481	3	evaluation	evaluation	NOUN
admet-2043	1481	4	of	of	ADP
admet-2043	1481	5	ph	ph	ADJ
admet-2043	1481	6	-	-	ADJ
admet-2043	1481	7	sensitive	sensitive	ADJ
admet-2043	1481	8	polymer	polymer	NOUN
admet-2043	1481	9	-	-	PUNCT
admet-2043	1481	10	based	base	VERB
admet-2043	1481	11	immunoliposomes	immunoliposome	NOUN
admet-2043	1481	12	targeting	target	VERB
admet-2043	1481	13	the	the	DET
admet-2043	1481	14	cd33	cd33	PROPN
admet-2043	1481	15	antigen	antigen	ADV
admet-2043	1481	16	.	.	PUNCT
admet-2043	1482	1	molecular	molecular	ADJ
admet-2043	1482	2	pharmaceutics	pharmaceutic	NOUN
admet-2043	1482	3	7	7	NUM
admet-2043	1482	4	(	(	PUNCT
admet-2043	1482	5	2010	2010	NUM
admet-2043	1482	6	)	)	PUNCT
admet-2043	1482	7	1098	1098	NUM
admet-2043	1482	8	-	-	SYM
admet-2043	1482	9	1107	1107	NUM
admet-2043	1482	10	.	.	PUNCT
admet-2043	1483	1	https://doi.org/10.1021/mp900261	https://doi.org/10.1021/mp900261	X
admet-2043	1483	2	m.	m.	NOUN
admet-2043	1484	1	[	[	X
admet-2043	1484	2	186	186	NUM
admet-2043	1484	3	]	]	PUNCT
admet-2043	1484	4	c.	c.	PROPN
admet-2043	1484	5	plank	plank	PROPN
admet-2043	1484	6	,	,	PUNCT
admet-2043	1484	7	b.	b.	PROPN
admet-2043	1484	8	oberhauser	oberhauser	PROPN
admet-2043	1484	9	,	,	PUNCT
admet-2043	1484	10	k.	k.	PROPN
admet-2043	1484	11	mechtler	mechtler	PROPN
admet-2043	1484	12	,	,	PUNCT
admet-2043	1484	13	c.	c.	PROPN
admet-2043	1484	14	koch	koch	PROPN
admet-2043	1484	15	,	,	PUNCT
admet-2043	1484	16	e.	e.	PROPN
admet-2043	1484	17	wagner	wagner	PROPN
admet-2043	1484	18	.	.	PUNCT
admet-2043	1485	1	the	the	DET
admet-2043	1485	2	influence	influence	NOUN
admet-2043	1485	3	of	of	ADP
admet-2043	1485	4	endosome	endosome	NOUN
admet-2043	1485	5	-	-	PUNCT
admet-2043	1485	6	disruptive	disruptive	ADJ
admet-2043	1485	7	peptides	peptide	NOUN
admet-2043	1485	8	on	on	ADP
admet-2043	1485	9	gene	gene	NOUN
admet-2043	1485	10	transfer	transfer	NOUN
admet-2043	1485	11	using	use	VERB
admet-2043	1485	12	synthetic	synthetic	ADJ
admet-2043	1485	13	virus	virus	NOUN
admet-2043	1485	14	-	-	PUNCT
admet-2043	1485	15	like	like	ADJ
admet-2043	1485	16	gene	gene	NOUN
admet-2043	1485	17	transfer	transfer	NOUN
admet-2043	1485	18	systems	system	NOUN
admet-2043	1485	19	.	.	PUNCT
admet-2043	1486	1	journal	journal	NOUN
admet-2043	1486	2	of	of	ADP
admet-2043	1486	3	biological	biological	ADJ
admet-2043	1486	4	chemistry	chemistry	NOUN
admet-2043	1486	5	269	269	NUM
admet-2043	1486	6	(	(	PUNCT
admet-2043	1486	7	1994	1994	NUM
admet-2043	1486	8	)	)	PUNCT
admet-2043	1486	9	12918	12918	NUM
admet-2043	1486	10	-	-	SYM
admet-2043	1486	11	12924	12924	NUM
admet-2043	1486	12	.	.	PUNCT
admet-2043	1487	1	https://doi.org/10.1016/s0021-9258(18)99963-1	https://doi.org/10.1016/s0021-9258(18)99963-1	PROPN
admet-2043	1487	2	.	.	PUNCT
admet-2043	1488	1	[	[	X
admet-2043	1488	2	187	187	NUM
admet-2043	1488	3	]	]	X
admet-2043	1488	4	a.k	a.k	PROPN
admet-2043	1488	5	.	.	PROPN
admet-2043	1488	6	varkouhi	varkouhi	PROPN
admet-2043	1488	7	,	,	PUNCT
admet-2043	1488	8	m.	m.	NOUN
admet-2043	1488	9	scholte	scholte	PROPN
admet-2043	1488	10	,	,	PUNCT
admet-2043	1488	11	g.	g.	PROPN
admet-2043	1488	12	storm	storm	PROPN
admet-2043	1488	13	,	,	PUNCT
admet-2043	1488	14	h.j	h.j	PROPN
admet-2043	1488	15	.	.	PROPN
admet-2043	1488	16	haisma	haisma	PROPN
admet-2043	1488	17	.	.	PUNCT
admet-2043	1489	1	endosomal	endosomal	ADJ
admet-2043	1489	2	escape	escape	NOUN
admet-2043	1489	3	pathways	pathway	NOUN
admet-2043	1489	4	for	for	ADP
admet-2043	1489	5	delivery	delivery	NOUN
admet-2043	1489	6	of	of	ADP
admet-2043	1489	7	biologicals	biological	NOUN
admet-2043	1489	8	.	.	PUNCT
admet-2043	1490	1	journal	journal	NOUN
admet-2043	1490	2	of	of	ADP
admet-2043	1490	3	controlled	control	VERB
admet-2043	1490	4	release	release	NOUN
admet-2043	1490	5	151	151	NUM
admet-2043	1490	6	(	(	PUNCT
admet-2043	1490	7	2011	2011	NUM
admet-2043	1490	8	)	)	PUNCT
admet-2043	1490	9	220	220	NUM
admet-2043	1490	10	-	-	SYM
admet-2043	1490	11	228	228	NUM
admet-2043	1490	12	.	.	PUNCT
admet-2043	1491	1	https://doi.org/10.1016/j.jconrel.2010.11.004	https://doi.org/10.1016/j.jconrel.2010.11.004	NOUN
admet-2043	1491	2	.	.	PUNCT
admet-2043	1492	1	[	[	X
admet-2043	1492	2	188	188	NUM
admet-2043	1492	3	]	]	PUNCT
admet-2043	1492	4	p.	p.	PROPN
admet-2043	1492	5	sapra	sapra	PROPN
admet-2043	1492	6	,	,	PUNCT
admet-2043	1492	7	t.m	t.m	PROPN
admet-2043	1492	8	.	.	PROPN
admet-2043	1492	9	allen	allen	PROPN
admet-2043	1492	10	.	.	PUNCT
admet-2043	1492	11	ligand	ligand	PROPN
admet-2043	1492	12	-	-	PUNCT
admet-2043	1492	13	targeted	target	VERB
admet-2043	1492	14	liposomal	liposomal	ADJ
admet-2043	1492	15	anticancer	anticancer	NOUN
admet-2043	1492	16	drugs	drug	NOUN
admet-2043	1492	17	.	.	PUNCT
admet-2043	1493	1	progress	progress	NOUN
admet-2043	1493	2	in	in	ADP
admet-2043	1493	3	lipid	lipid	PROPN
admet-2043	1493	4	research	research	NOUN
admet-2043	1493	5	42	42	NUM
admet-2043	1493	6	(	(	PUNCT
admet-2043	1493	7	2003	2003	NUM
admet-2043	1493	8	)	)	PUNCT
admet-2043	1493	9	439	439	NUM
admet-2043	1493	10	-	-	SYM
admet-2043	1493	11	462	462	NUM
admet-2043	1493	12	.	.	PUNCT
admet-2043	1494	1	https://doi.org/10.1016/s0163-7827(03)00032-8	https://doi.org/10.1016/s0163-7827(03)00032-8	PROPN
admet-2043	1494	2	.	.	PUNCT
admet-2043	1495	1	[	[	X
admet-2043	1495	2	189	189	NUM
admet-2043	1495	3	]	]	X
admet-2043	1495	4	g.	g.	PROPN
admet-2043	1495	5	oberdorster	oberdorster	NOUN
admet-2043	1495	6	.	.	PUNCT
admet-2043	1496	1	safety	safety	NOUN
admet-2043	1496	2	assessment	assessment	NOUN
admet-2043	1496	3	for	for	ADP
admet-2043	1496	4	nanotechnology	nanotechnology	NOUN
admet-2043	1496	5	and	and	CCONJ
admet-2043	1496	6	nanomedicine	nanomedicine	NOUN
admet-2043	1496	7	:	:	PUNCT
admet-2043	1496	8	concepts	concept	NOUN
admet-2043	1496	9	of	of	ADP
admet-2043	1496	10	nanotoxicology	nanotoxicology	NOUN
admet-2043	1496	11	.	.	PUNCT
admet-2043	1497	1	journal	journal	PROPN
admet-2043	1497	2	of	of	ADP
admet-2043	1497	3	internal	internal	ADJ
admet-2043	1497	4	medicine	medicine	NOUN
admet-2043	1497	5	267	267	NUM
admet-2043	1497	6	(	(	PUNCT
admet-2043	1497	7	2010	2010	NUM
admet-2043	1497	8	)	)	PUNCT
admet-2043	1497	9	89	89	NUM
admet-2043	1497	10	-	-	SYM
admet-2043	1497	11	105	105	NUM
admet-2043	1497	12	.	.	PUNCT
admet-2043	1498	1	https://doi.org/10.1111/j.13652796.2009.02187.x	https://doi.org/10.1111/j.13652796.2009.02187.x	X
admet-2043	1498	2	.	.	PUNCT
admet-2043	1499	1	[	[	X
admet-2043	1499	2	190	190	NUM
admet-2043	1499	3	]	]	X
admet-2043	1499	4	h.r	h.r	PROPN
admet-2043	1499	5	.	.	PROPN
admet-2043	1499	6	jia	jia	PROPN
admet-2043	1499	7	,	,	PUNCT
admet-2043	1499	8	y.x	y.x	PROPN
admet-2043	1499	9	.	.	PROPN
admet-2043	1499	10	zhu	zhu	PROPN
admet-2043	1499	11	,	,	PUNCT
admet-2043	1499	12	q.y	q.y	PROPN
admet-2043	1499	13	.	.	PROPN
admet-2043	1499	14	duan	duan	PROPN
admet-2043	1499	15	,	,	PUNCT
admet-2043	1499	16	z.	z.	PROPN
admet-2043	1499	17	chen	chen	PROPN
admet-2043	1499	18	,	,	PUNCT
admet-2043	1499	19	f.g	f.g	PROPN
admet-2043	1499	20	.	.	PUNCT
admet-2043	1499	21	wu	wu	PROPN
admet-2043	1499	22	.	.	PUNCT
admet-2043	1500	1	nanomaterials	nanomaterial	NOUN
admet-2043	1500	2	meet	meet	VERB
admet-2043	1500	3	zebrafish	zebrafish	ADJ
admet-2043	1500	4	:	:	PUNCT
admet-2043	1500	5	toxicity	toxicity	NOUN
admet-2043	1500	6	evaluation	evaluation	NOUN
admet-2043	1500	7	and	and	CCONJ
admet-2043	1500	8	drug	drug	NOUN
admet-2043	1500	9	delivery	delivery	NOUN
admet-2043	1500	10	applications	application	NOUN
admet-2043	1500	11	.	.	PUNCT
admet-2043	1501	1	journal	journal	PROPN
admet-2043	1501	2	of	of	ADP
admet-2043	1501	3	controlled	control	VERB
admet-2043	1501	4	release	release	NOUN
admet-2043	1501	5	311	311	NUM
admet-2043	1501	6	-	-	SYM
admet-2043	1501	7	312	312	NUM
admet-2043	1501	8	(	(	PUNCT
admet-2043	1501	9	2019	2019	NUM
admet-2043	1501	10	)	)	PUNCT
admet-2043	1501	11	301	301	NUM
admet-2043	1501	12	-	-	SYM
admet-2043	1501	13	318	318	NUM
admet-2043	1501	14	.	.	PUNCT
admet-2043	1502	1	https://doi.org/10.1016/j.jconrel.2019.08.022	https://doi.org/10.1016/j.jconrel.2019.08.022	NOUN
admet-2043	1502	2	.	.	PUNCT
admet-2043	1503	1	[	[	X
admet-2043	1503	2	191	191	NUM
admet-2043	1503	3	]	]	X
admet-2043	1503	4	m.g	m.g	PROPN
admet-2043	1503	5	.	.	PROPN
admet-2043	1503	6	tirumala	tirumala	PROPN
admet-2043	1503	7	,	,	PUNCT
admet-2043	1503	8	p.	p.	NOUN
admet-2043	1503	9	anchi	anchi	PROPN
admet-2043	1503	10	,	,	PUNCT
admet-2043	1503	11	s.	s.	PROPN
admet-2043	1503	12	raja	raja	PROPN
admet-2043	1503	13	,	,	PUNCT
admet-2043	1503	14	m.	m.	NOUN
admet-2043	1503	15	rachamalla	rachamalla	NOUN
admet-2043	1503	16	,	,	PUNCT
admet-2043	1503	17	c.	c.	PROPN
admet-2043	1503	18	godugu	godugu	NOUN
admet-2043	1503	19	.	.	PUNCT
admet-2043	1504	1	novel	novel	ADJ
admet-2043	1504	2	methods	method	NOUN
admet-2043	1504	3	and	and	CCONJ
admet-2043	1504	4	approaches	approach	NOUN
admet-2043	1504	5	for	for	ADP
admet-2043	1504	6	safety	safety	NOUN
admet-2043	1504	7	evaluation	evaluation	NOUN
admet-2043	1504	8	of	of	ADP
admet-2043	1504	9	nanoparticle	nanoparticle	NOUN
admet-2043	1504	10	formulations	formulation	NOUN
admet-2043	1504	11	:	:	PUNCT
admet-2043	1504	12	a	a	DET
admet-2043	1504	13	focus	focus	NOUN
admet-2043	1504	14	towards	towards	ADP
admet-2043	1504	15	in	in	ADP
admet-2043	1504	16	vitro	vitro	X
admet-2043	1504	17	models	model	NOUN
admet-2043	1504	18	and	and	CCONJ
admet-2043	1504	19	adverse	adverse	ADJ
admet-2043	1504	20	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1504	21	https://doi.org/10.1016/j.ultrasmedbio.2009.03.012	https://doi.org/10.1016/j.ultrasmedbio.2009.03.012	NOUN
admet-2043	1504	22	https://doi.org/10.1016/j.jconrel.2017.08.033	https://doi.org/10.1016/j.jconrel.2017.08.033	VERB
admet-2043	1504	23	https://doi.org/10.1016/s0378-5173(02)00649-x	https://doi.org/10.1016/s0378-5173(02)00649-x	PROPN
admet-2043	1504	24	https://doi.org/10.3390/pharmaceutics13081183	https://doi.org/10.3390/pharmaceutics13081183	PROPN
admet-2043	1504	25	https://doi.org/10.1111/jphp.12347	https://doi.org/10.1111/jphp.12347	ADJ
admet-2043	1504	26	https://doi.org/10.1016/j.colsurfb.2014.06.037	https://doi.org/10.1016/j.colsurfb.2014.06.037	VERB
admet-2043	1504	27	https://doi.org/10.1073/pnas.1103573108	https://doi.org/10.1073/pnas.1103573108	NOUN
admet-2043	1504	28	https://doi.org/10.1016/j.biomaterials.2013.04.032	https://doi.org/10.1016/j.biomaterials.2013.04.032	PRON
admet-2043	1504	29	https://doi.org/10.1517/17425240902939143	https://doi.org/10.1517/17425240902939143	ADV
admet-2043	1504	30	https://doi.org/10.1177/030089160809400220	https://doi.org/10.1177/030089160809400220	VERB
admet-2043	1504	31	https://doi.org/10.1021/mp900261	https://doi.org/10.1021/mp900261	X
admet-2043	1504	32	m	m	VERB
admet-2043	1504	33	https://doi.org/10.1016/s0021-9258(18)99963-1	https://doi.org/10.1016/s0021-9258(18)99963-1	ADJ
admet-2043	1504	34	https://doi.org/10.1016/j.jconrel.2010.11.004	https://doi.org/10.1016/j.jconrel.2010.11.004	NOUN
admet-2043	1504	35	https://doi.org/10.1016/s0163-7827(03)00032-8	https://doi.org/10.1016/s0163-7827(03)00032-8	PROPN
admet-2043	1504	36	https://doi.org/10.1111/j.1365-2796.2009.02187.x	https://doi.org/10.1111/j.1365-2796.2009.02187.x	PROPN
admet-2043	1505	1	https://doi.org/10.1111/j.1365-2796.2009.02187.x	https://doi.org/10.1111/j.1365-2796.2009.02187.x	PROPN
admet-2043	1505	2	https://doi.org/10.1016/j.jconrel.2019.08.022	https://doi.org/10.1016/j.jconrel.2019.08.022	NOUN
admet-2043	1505	3	m.	m.	NOUN
admet-2043	1505	4	kulkarni	kulkarni	PROPN
admet-2043	1505	5	et	et	PROPN
admet-2043	1505	6	al	al	PROPN
admet-2043	1505	7	.	.	PROPN
admet-2043	1505	8	admet	admet	PROPN
admet-2043	1505	9	&	&	CCONJ
admet-2043	1505	10	dmpk	dmpk	PROPN
admet-2043	1505	11	12(1	12(1	PROPN
admet-2043	1505	12	)	)	PUNCT
admet-2043	1505	13	(	(	PUNCT
admet-2043	1505	14	2024	2024	NUM
admet-2043	1505	15	)	)	PUNCT
admet-2043	1505	16	63	63	NUM
admet-2043	1505	17	-	-	SYM
admet-2043	1505	18	105	105	NUM
admet-2043	1505	19	104	104	NUM
admet-2043	1505	20	outcome	outcome	NOUN
admet-2043	1505	21	pathways	pathway	NOUN
admet-2043	1505	22	.	.	PUNCT
admet-2043	1506	1	frontiers	frontier	NOUN
admet-2043	1506	2	in	in	ADP
admet-2043	1506	3	pharmacology	pharmacology	NOUN
admet-2043	1506	4	12	12	NUM
admet-2043	1506	5	(	(	PUNCT
admet-2043	1506	6	2021	2021	NUM
admet-2043	1506	7	)	)	PUNCT
admet-2043	1506	8	612659	612659	NUM
admet-2043	1506	9	.	.	PUNCT
admet-2043	1507	1	https://doi.org/10.3389/fphar.2021.612659	https://doi.org/10.3389/fphar.2021.612659	PROPN
admet-2043	1507	2	.	.	PUNCT
admet-2043	1508	1	[	[	X
admet-2043	1508	2	192	192	NUM
admet-2043	1508	3	]	]	X
admet-2043	1508	4	t.a	t.a	PROPN
admet-2043	1508	5	.	.	PROPN
admet-2043	1508	6	faunce	faunce	PROPN
admet-2043	1508	7	,	,	PUNCT
admet-2043	1508	8	j.	j.	PROPN
admet-2043	1508	9	white	white	PROPN
admet-2043	1508	10	,	,	PUNCT
admet-2043	1508	11	k.i	k.i	PROPN
admet-2043	1508	12	.	.	PUNCT
admet-2043	1508	13	matthaei	matthaei	PROPN
admet-2043	1508	14	.	.	PUNCT
admet-2043	1508	15	integrated	integrate	VERB
admet-2043	1508	16	research	research	NOUN
admet-2043	1508	17	into	into	ADP
admet-2043	1508	18	the	the	DET
admet-2043	1508	19	nanoparticle	nanoparticle	NOUN
admet-2043	1508	20	-	-	PUNCT
admet-2043	1508	21	protein	protein	NOUN
admet-2043	1508	22	corona	corona	NOUN
admet-2043	1508	23	:	:	PUNCT
admet-2043	1508	24	a	a	DET
admet-2043	1508	25	new	new	ADJ
admet-2043	1508	26	focus	focus	NOUN
admet-2043	1508	27	for	for	ADP
admet-2043	1508	28	safe	safe	ADJ
admet-2043	1508	29	,	,	PUNCT
admet-2043	1508	30	sustainable	sustainable	ADJ
admet-2043	1508	31	and	and	CCONJ
admet-2043	1508	32	equitable	equitable	ADJ
admet-2043	1508	33	development	development	NOUN
admet-2043	1508	34	of	of	ADP
admet-2043	1508	35	nanomedicines	nanomedicine	NOUN
admet-2043	1508	36	.	.	PUNCT
admet-2043	1509	1	nanomedicine	nanomedicine	NOUN
admet-2043	1509	2	(	(	PUNCT
admet-2043	1509	3	lond	lond	PROPN
admet-2043	1509	4	)	)	PUNCT
admet-2043	1509	5	3	3	NUM
admet-2043	1509	6	(	(	PUNCT
admet-2043	1509	7	2008	2008	NUM
admet-2043	1509	8	)	)	PUNCT
admet-2043	1509	9	859	859	NUM
admet-2043	1509	10	-	-	SYM
admet-2043	1509	11	866	866	NUM
admet-2043	1509	12	.	.	PUNCT
admet-2043	1510	1	https://doi.org/10.2217/17435889.3.6.859	https://doi.org/10.2217/17435889.3.6.859	PROPN
admet-2043	1510	2	.	.	PUNCT
admet-2043	1511	1	[	[	X
admet-2043	1511	2	193	193	NUM
admet-2043	1511	3	]	]	SYM
admet-2043	1511	4	m.r.c	m.r.c	NOUN
admet-2043	1511	5	.	.	PUNCT
admet-2043	1511	6	marques	marques	PROPN
admet-2043	1511	7	,	,	PUNCT
admet-2043	1511	8	q.	q.	PROPN
admet-2043	1511	9	choo	choo	PROPN
admet-2043	1511	10	,	,	PUNCT
admet-2043	1511	11	m.	m.	NOUN
admet-2043	1511	12	ashtikar	ashtikar	PROPN
admet-2043	1511	13	,	,	PUNCT
admet-2043	1511	14	t.c	t.c	PROPN
admet-2043	1511	15	.	.	PROPN
admet-2043	1511	16	rocha	rocha	PROPN
admet-2043	1511	17	,	,	PUNCT
admet-2043	1511	18	s.	s.	PROPN
admet-2043	1511	19	bremer	bremer	PROPN
admet-2043	1511	20	-	-	PUNCT
admet-2043	1511	21	hoffmann	hoffmann	PROPN
admet-2043	1511	22	,	,	PUNCT
admet-2043	1511	23	m.g	m.g	PROPN
admet-2043	1511	24	.	.	PROPN
admet-2043	1511	25	wacker	wacker	PROPN
admet-2043	1511	26	.	.	PUNCT
admet-2043	1511	27	nanomedicines	nanomedicine	VERB
admet-2043	1511	28	tiny	tiny	ADJ
admet-2043	1511	29	particles	particle	NOUN
admet-2043	1511	30	and	and	CCONJ
admet-2043	1511	31	big	big	ADJ
admet-2043	1511	32	challenges	challenge	NOUN
admet-2043	1511	33	.	.	PUNCT
admet-2043	1512	1	advanced	advanced	ADJ
admet-2043	1512	2	drug	drug	NOUN
admet-2043	1512	3	delivery	delivery	NOUN
admet-2043	1512	4	reviews	review	VERB
admet-2043	1512	5	151	151	NUM
admet-2043	1512	6	-	-	SYM
admet-2043	1512	7	152	152	NUM
admet-2043	1512	8	(	(	PUNCT
admet-2043	1512	9	2019	2019	NUM
admet-2043	1512	10	)	)	PUNCT
admet-2043	1512	11	23	23	NUM
admet-2043	1512	12	-	-	SYM
admet-2043	1512	13	43	43	NUM
admet-2043	1512	14	.	.	PUNCT
admet-2043	1513	1	https://doi.org/10.1016/j.addr.2019.06.003	https://doi.org/10.1016/j.addr.2019.06.003	PROPN
admet-2043	1513	2	.	.	PUNCT
admet-2043	1514	1	[	[	X
admet-2043	1514	2	194	194	NUM
admet-2043	1514	3	]	]	X
admet-2043	1514	4	c.	c.	PROPN
admet-2043	1514	5	von	von	PROPN
admet-2043	1514	6	roemeling	roemeling	PROPN
admet-2043	1514	7	,	,	PUNCT
admet-2043	1514	8	w.	w.	PROPN
admet-2043	1514	9	jiang	jiang	PROPN
admet-2043	1514	10	,	,	PUNCT
admet-2043	1514	11	c.k	c.k	PROPN
admet-2043	1514	12	.	.	PROPN
admet-2043	1514	13	chan	chan	PROPN
admet-2043	1514	14	,	,	PUNCT
admet-2043	1514	15	i.l	i.l	PROPN
admet-2043	1514	16	.	.	PROPN
admet-2043	1514	17	weissman	weissman	PROPN
admet-2043	1514	18	,	,	PUNCT
admet-2043	1514	19	b.y.s	b.y.s	PROPN
admet-2043	1514	20	.	.	PUNCT
admet-2043	1515	1	kim	kim	PROPN
admet-2043	1515	2	.	.	PUNCT
admet-2043	1516	1	breaking	break	VERB
admet-2043	1516	2	down	down	ADP
admet-2043	1516	3	the	the	DET
admet-2043	1516	4	barriers	barrier	NOUN
admet-2043	1516	5	to	to	PART
admet-2043	1516	6	precision	precision	VERB
admet-2043	1516	7	cancer	cancer	NOUN
admet-2043	1516	8	nanomedicine	nanomedicine	NOUN
admet-2043	1516	9	.	.	PUNCT
admet-2043	1517	1	trends	trend	NOUN
admet-2043	1517	2	in	in	ADP
admet-2043	1517	3	biotechnology	biotechnology	NOUN
admet-2043	1517	4	35	35	NUM
admet-2043	1517	5	(	(	PUNCT
admet-2043	1517	6	2017	2017	NUM
admet-2043	1517	7	)	)	PUNCT
admet-2043	1517	8	159	159	NUM
admet-2043	1517	9	-	-	SYM
admet-2043	1517	10	171	171	NUM
admet-2043	1517	11	.	.	PUNCT
admet-2043	1518	1	https://doi.org/10.1016/j.tibtech.2016.07.006	https://doi.org/10.1016/j.tibtech.2016.07.006	NOUN
admet-2043	1518	2	.	.	PUNCT
admet-2043	1519	1	[	[	X
admet-2043	1519	2	195	195	NUM
admet-2043	1519	3	]	]	X
admet-2043	1519	4	c.	c.	PROPN
admet-2043	1519	5	oerlemans	oerlemans	PROPN
admet-2043	1519	6	,	,	PUNCT
admet-2043	1519	7	w.	w.	NOUN
admet-2043	1519	8	bult	bult	PROPN
admet-2043	1519	9	,	,	PUNCT
admet-2043	1519	10	m.	m.	NOUN
admet-2043	1519	11	bos	bos	PROPN
admet-2043	1519	12	,	,	PUNCT
admet-2043	1519	13	g.	g.	PROPN
admet-2043	1519	14	storm	storm	PROPN
admet-2043	1519	15	,	,	PUNCT
admet-2043	1519	16	j.f	j.f	PROPN
admet-2043	1519	17	.	.	PROPN
admet-2043	1519	18	nijsen	nijsen	PROPN
admet-2043	1519	19	,	,	PUNCT
admet-2043	1519	20	w.e	w.e	PROPN
admet-2043	1519	21	.	.	PROPN
admet-2043	1519	22	hennink	hennink	PROPN
admet-2043	1519	23	.	.	PUNCT
admet-2043	1520	1	polymeric	polymeric	ADJ
admet-2043	1520	2	micelles	micelle	NOUN
admet-2043	1520	3	in	in	ADP
admet-2043	1520	4	anticancer	anticancer	NOUN
admet-2043	1520	5	therapy	therapy	NOUN
admet-2043	1520	6	:	:	PUNCT
admet-2043	1520	7	targeting	targeting	NOUN
admet-2043	1520	8	,	,	PUNCT
admet-2043	1520	9	imaging	imaging	NOUN
admet-2043	1520	10	and	and	CCONJ
admet-2043	1520	11	triggered	trigger	VERB
admet-2043	1520	12	release	release	NOUN
admet-2043	1520	13	.	.	PUNCT
admet-2043	1521	1	pharmaceutical	pharmaceutical	PROPN
admet-2043	1521	2	research	research	NOUN
admet-2043	1521	3	27	27	NUM
admet-2043	1521	4	(	(	PUNCT
admet-2043	1521	5	2010	2010	NUM
admet-2043	1521	6	)	)	PUNCT
admet-2043	1521	7	2569	2569	NUM
admet-2043	1521	8	-	-	PUNCT
admet-2043	1521	9	2589	2589	NUM
admet-2043	1521	10	.	.	PUNCT
admet-2043	1522	1	https://doi.org/10.1007/s11095-010-0233-4	https://doi.org/10.1007/s11095-010-0233-4	PROPN
admet-2043	1522	2	.	.	PUNCT
admet-2043	1523	1	[	[	X
admet-2043	1523	2	196	196	NUM
admet-2043	1523	3	]	]	PUNCT
admet-2043	1523	4	x.	x.	PROPN
admet-2043	1523	5	zhang	zhang	PROPN
admet-2043	1523	6	,	,	PUNCT
admet-2043	1523	7	y.	y.	PROPN
admet-2043	1523	8	huang	huang	PROPN
admet-2043	1523	9	,	,	PUNCT
admet-2043	1523	10	s.	s.	PROPN
admet-2043	1523	11	li	li	PROPN
admet-2043	1523	12	.	.	PROPN
admet-2043	1523	13	nanomicellar	nanomicellar	ADJ
admet-2043	1523	14	carriers	carrier	NOUN
admet-2043	1523	15	for	for	ADP
admet-2043	1523	16	targeted	target	VERB
admet-2043	1523	17	delivery	delivery	NOUN
admet-2043	1523	18	of	of	ADP
admet-2043	1523	19	anticancer	anticancer	NOUN
admet-2043	1523	20	agents	agent	NOUN
admet-2043	1523	21	.	.	PUNCT
admet-2043	1524	1	therapeutic	therapeutic	ADJ
admet-2043	1524	2	delivery	delivery	NOUN
admet-2043	1524	3	5	5	NUM
admet-2043	1524	4	(	(	PUNCT
admet-2043	1524	5	2014	2014	NUM
admet-2043	1524	6	)	)	PUNCT
admet-2043	1524	7	53	53	NUM
admet-2043	1524	8	-	-	SYM
admet-2043	1524	9	68	68	NUM
admet-2043	1524	10	.	.	PUNCT
admet-2043	1525	1	https://doi.org/10.4155/tde.13.135	https://doi.org/10.4155/tde.13.135	X
admet-2043	1525	2	.	.	PUNCT
admet-2043	1526	1	[	[	X
admet-2043	1526	2	197	197	NUM
admet-2043	1526	3	]	]	PUNCT
admet-2043	1526	4	a.	a.	NOUN
admet-2043	1526	5	quintana	quintana	PROPN
admet-2043	1526	6	,	,	PUNCT
admet-2043	1526	7	e.	e.	PROPN
admet-2043	1526	8	raczka	raczka	PROPN
admet-2043	1526	9	,	,	PUNCT
admet-2043	1526	10	l.	l.	PROPN
admet-2043	1526	11	piehler	piehler	PROPN
admet-2043	1526	12	,	,	PUNCT
admet-2043	1526	13	i.	i.	PROPN
admet-2043	1526	14	lee	lee	PROPN
admet-2043	1526	15	,	,	PUNCT
admet-2043	1526	16	a.	a.	PROPN
admet-2043	1526	17	myc	myc	PROPN
admet-2043	1526	18	,	,	PUNCT
admet-2043	1526	19	i.	i.	PROPN
admet-2043	1526	20	majoros	majoros	PROPN
admet-2043	1526	21	,	,	PUNCT
admet-2043	1526	22	a.k	a.k	PROPN
admet-2043	1526	23	.	.	PROPN
admet-2043	1526	24	patri	patri	PROPN
admet-2043	1526	25	,	,	PUNCT
admet-2043	1526	26	t.	t.	PROPN
admet-2043	1526	27	thomas	thomas	PROPN
admet-2043	1526	28	,	,	PUNCT
admet-2043	1526	29	j.	j.	PROPN
admet-2043	1526	30	mule	mule	PROPN
admet-2043	1526	31	,	,	PUNCT
admet-2043	1526	32	j.r	j.r	PROPN
admet-2043	1526	33	.	.	PROPN
admet-2043	1526	34	baker	baker	PROPN
admet-2043	1526	35	,	,	PUNCT
admet-2043	1526	36	jr	jr	PROPN
admet-2043	1526	37	.	.	PROPN
admet-2043	1526	38	design	design	NOUN
admet-2043	1526	39	and	and	CCONJ
admet-2043	1526	40	function	function	NOUN
admet-2043	1526	41	of	of	ADP
admet-2043	1526	42	a	a	DET
admet-2043	1526	43	dendrimer	dendrimer	NOUN
admet-2043	1526	44	-	-	PUNCT
admet-2043	1526	45	based	base	VERB
admet-2043	1526	46	therapeutic	therapeutic	ADJ
admet-2043	1526	47	nanodevice	nanodevice	NOUN
admet-2043	1526	48	targeted	target	VERB
admet-2043	1526	49	to	to	ADP
admet-2043	1526	50	tumor	tumor	NOUN
admet-2043	1526	51	cells	cell	NOUN
admet-2043	1526	52	through	through	ADP
admet-2043	1526	53	the	the	DET
admet-2043	1526	54	folate	folate	NOUN
admet-2043	1526	55	receptor	receptor	NOUN
admet-2043	1526	56	.	.	PUNCT
admet-2043	1527	1	pharmaceutical	pharmaceutical	ADJ
admet-2043	1527	2	research	research	NOUN
admet-2043	1527	3	19	19	NUM
admet-2043	1527	4	(	(	PUNCT
admet-2043	1527	5	2002	2002	NUM
admet-2043	1527	6	)	)	PUNCT
admet-2043	1527	7	1310	1310	NUM
admet-2043	1527	8	-	-	SYM
admet-2043	1527	9	1316	1316	NUM
admet-2043	1527	10	.	.	PUNCT
admet-2043	1528	1	https://doi.org/10.1023/a:1020398624602	https://doi.org/10.1023/a:1020398624602	NOUN
admet-2043	1528	2	.	.	PUNCT
admet-2043	1529	1	[	[	X
admet-2043	1529	2	198	198	NUM
admet-2043	1529	3	]	]	PUNCT
admet-2043	1529	4	s.	s.	PROPN
admet-2043	1529	5	somani	somani	PROPN
admet-2043	1529	6	,	,	PUNCT
admet-2043	1529	7	c.	c.	PROPN
admet-2043	1529	8	dufes	dufes	PROPN
admet-2043	1529	9	.	.	PUNCT
admet-2043	1530	1	applications	application	NOUN
admet-2043	1530	2	of	of	ADP
admet-2043	1530	3	dendrimers	dendrimer	NOUN
admet-2043	1530	4	for	for	ADP
admet-2043	1530	5	brain	brain	NOUN
admet-2043	1530	6	delivery	delivery	NOUN
admet-2043	1530	7	and	and	CCONJ
admet-2043	1530	8	cancer	cancer	NOUN
admet-2043	1530	9	therapy	therapy	NOUN
admet-2043	1530	10	.	.	PUNCT
admet-2043	1531	1	nanomedicine	nanomedicine	NOUN
admet-2043	1531	2	(	(	PUNCT
admet-2043	1531	3	lond	lond	ADJ
admet-2043	1531	4	)	)	PUNCT
admet-2043	1531	5	9	9	NUM
admet-2043	1531	6	(	(	PUNCT
admet-2043	1531	7	2014	2014	NUM
admet-2043	1531	8	)	)	PUNCT
admet-2043	1531	9	2403	2403	NUM
admet-2043	1531	10	-	-	SYM
admet-2043	1531	11	2414	2414	NUM
admet-2043	1531	12	.	.	PUNCT
admet-2043	1532	1	https://doi.org/10.2217/nnm.14.130	https://doi.org/10.2217/nnm.14.130	NOUN
admet-2043	1532	2	.	.	PUNCT
admet-2043	1533	1	[	[	X
admet-2043	1533	2	199	199	NUM
admet-2043	1533	3	]	]	X
admet-2043	1533	4	b.	b.	PROPN
admet-2043	1533	5	dinesh	dinesh	PROPN
admet-2043	1533	6	,	,	PUNCT
admet-2043	1533	7	a.	a.	PROPN
admet-2043	1533	8	bianco	bianco	PROPN
admet-2043	1533	9	,	,	PUNCT
admet-2043	1533	10	c.	c.	PROPN
admet-2043	1533	11	menard	menard	PROPN
admet-2043	1533	12	-	-	PUNCT
admet-2043	1533	13	moyon	moyon	NOUN
admet-2043	1533	14	.	.	PUNCT
admet-2043	1534	1	designing	design	VERB
admet-2043	1534	2	multimodal	multimodal	NOUN
admet-2043	1534	3	carbon	carbon	NOUN
admet-2043	1534	4	nanotubes	nanotube	NOUN
admet-2043	1534	5	by	by	ADP
admet-2043	1534	6	covalent	covalent	ADJ
admet-2043	1534	7	multi	multi	NOUN
admet-2043	1534	8	-	-	NOUN
admet-2043	1534	9	functionalization	functionalization	NOUN
admet-2043	1534	10	.	.	PUNCT
admet-2043	1535	1	nanoscale	nanoscale	NOUN
admet-2043	1535	2	8	8	NUM
admet-2043	1535	3	(	(	PUNCT
admet-2043	1535	4	2016	2016	NUM
admet-2043	1535	5	)	)	PUNCT
admet-2043	1535	6	18596	18596	NUM
admet-2043	1535	7	-	-	SYM
admet-2043	1535	8	18611	18611	NUM
admet-2043	1535	9	.	.	PUNCT
admet-2043	1536	1	https://doi.org/10.1039/c6nr06728j	https://doi.org/10.1039/c6nr06728j	NOUN
admet-2043	1536	2	.	.	PUNCT
admet-2043	1537	1	[	[	X
admet-2043	1537	2	200	200	NUM
admet-2043	1537	3	]	]	PUNCT
admet-2043	1537	4	z.	z.	PROPN
admet-2043	1537	5	chen	chen	PROPN
admet-2043	1537	6	,	,	PUNCT
admet-2043	1537	7	r.	r.	PROPN
admet-2043	1537	8	mao	mao	PROPN
admet-2043	1537	9	,	,	PUNCT
admet-2043	1537	10	y.	y.	PROPN
admet-2043	1537	11	liu	liu	PROPN
admet-2043	1537	12	.	.	PUNCT
admet-2043	1538	1	fullerenes	fullerene	NOUN
admet-2043	1538	2	for	for	ADP
admet-2043	1538	3	cancer	cancer	NOUN
admet-2043	1538	4	diagnosis	diagnosis	NOUN
admet-2043	1538	5	and	and	CCONJ
admet-2043	1538	6	therapy	therapy	NOUN
admet-2043	1538	7	:	:	PUNCT
admet-2043	1538	8	preparation	preparation	NOUN
admet-2043	1538	9	,	,	PUNCT
admet-2043	1538	10	biological	biological	ADJ
admet-2043	1538	11	and	and	CCONJ
admet-2043	1538	12	clinical	clinical	ADJ
admet-2043	1538	13	perspectives	perspective	NOUN
admet-2043	1538	14	.	.	PUNCT
admet-2043	1539	1	current	current	ADJ
admet-2043	1539	2	drug	drug	NOUN
admet-2043	1539	3	metabolism	metabolism	NOUN
admet-2043	1539	4	13	13	NUM
admet-2043	1539	5	(	(	PUNCT
admet-2043	1539	6	2012	2012	NUM
admet-2043	1539	7	)	)	PUNCT
admet-2043	1539	8	1035	1035	NUM
admet-2043	1539	9	-	-	SYM
admet-2043	1539	10	1045	1045	NUM
admet-2043	1539	11	.	.	PUNCT
admet-2043	1540	1	https://doi.org/10.2174/138920012802850128	https://doi.org/10.2174/138920012802850128	NOUN
admet-2043	1540	2	.	.	PUNCT
admet-2043	1541	1	[	[	X
admet-2043	1541	2	201	201	NUM
admet-2043	1541	3	]	]	X
admet-2043	1541	4	j.	j.	PROPN
admet-2043	1541	5	li	li	PROPN
admet-2043	1541	6	,	,	PUNCT
admet-2043	1541	7	j.j	j.j	PROPN
admet-2043	1541	8	.	.	PROPN
admet-2043	1541	9	zhu	zhu	PROPN
admet-2043	1541	10	.	.	PUNCT
admet-2043	1541	11	quantum	quantum	ADJ
admet-2043	1541	12	dots	dot	NOUN
admet-2043	1541	13	for	for	ADP
admet-2043	1541	14	fluorescent	fluorescent	ADJ
admet-2043	1541	15	biosensing	biosensing	NOUN
admet-2043	1541	16	and	and	CCONJ
admet-2043	1541	17	bio	bio	ADJ
admet-2043	1541	18	-	-	ADJ
admet-2043	1541	19	imaging	imaging	ADJ
admet-2043	1541	20	applications	application	NOUN
admet-2043	1541	21	.	.	PUNCT
admet-2043	1542	1	analyst	analyst	NOUN
admet-2043	1542	2	138	138	NUM
admet-2043	1542	3	(	(	PUNCT
admet-2043	1542	4	2013	2013	NUM
admet-2043	1542	5	)	)	PUNCT
admet-2043	1542	6	2506	2506	NUM
admet-2043	1542	7	-	-	SYM
admet-2043	1542	8	2515	2515	NUM
admet-2043	1542	9	.	.	PUNCT
admet-2043	1543	1	https://doi.org/10.1039/c3an36705c	https://doi.org/10.1039/c3an36705c	NUM
admet-2043	1543	2	.	.	PUNCT
admet-2043	1544	1	[	[	X
admet-2043	1544	2	202	202	NUM
admet-2043	1544	3	]	]	X
admet-2043	1544	4	r.	r.	PROPN
admet-2043	1544	5	datta	datta	PROPN
admet-2043	1544	6	,	,	PUNCT
admet-2043	1544	7	s.s	s.s	PROPN
admet-2043	1544	8	.	.	PROPN
admet-2043	1544	9	jaitawat	jaitawat	PROPN
admet-2043	1544	10	.	.	PUNCT
admet-2043	1545	1	nanotechnology	nanotechnology	PROPN
admet-2043	1545	2	the	the	DET
admet-2043	1545	3	new	new	ADJ
admet-2043	1545	4	frontier	frontier	NOUN
admet-2043	1545	5	of	of	ADP
admet-2043	1545	6	medicine	medicine	NOUN
admet-2043	1545	7	.	.	PUNCT
admet-2043	1546	1	medical	medical	ADJ
admet-2043	1546	2	journal	journal	PROPN
admet-2043	1546	3	armed	armed	ADJ
admet-2043	1546	4	forces	force	NOUN
admet-2043	1546	5	india	india	PROPN
admet-2043	1546	6	62	62	NUM
admet-2043	1546	7	(	(	PUNCT
admet-2043	1546	8	2006	2006	NUM
admet-2043	1546	9	)	)	PUNCT
admet-2043	1546	10	263	263	NUM
admet-2043	1546	11	-	-	SYM
admet-2043	1546	12	268	268	NUM
admet-2043	1546	13	.	.	PUNCT
admet-2043	1547	1	https://doi.org/10.1016/s0377-1237(06)80016-x	https://doi.org/10.1016/s0377-1237(06)80016-x	NOUN
admet-2043	1547	2	.	.	PUNCT
admet-2043	1548	1	[	[	X
admet-2043	1548	2	203	203	NUM
admet-2043	1548	3	]	]	PUNCT
admet-2043	1548	4	v.	v.	CCONJ
admet-2043	1548	5	sagar	sagar	PROPN
admet-2043	1548	6	,	,	PUNCT
admet-2043	1548	7	s.	s.	PROPN
admet-2043	1548	8	pilakka	pilakka	PROPN
admet-2043	1548	9	-	-	PUNCT
admet-2043	1548	10	kanthikeel	kanthikeel	PROPN
admet-2043	1548	11	,	,	PUNCT
admet-2043	1548	12	r.	r.	PROPN
admet-2043	1548	13	pottathil	pottathil	PROPN
admet-2043	1548	14	,	,	PUNCT
admet-2043	1548	15	s.k	s.k	PROPN
admet-2043	1548	16	.	.	PROPN
admet-2043	1548	17	saxena	saxena	PROPN
admet-2043	1548	18	,	,	PUNCT
admet-2043	1548	19	m.	m.	NOUN
admet-2043	1548	20	nair	nair	PROPN
admet-2043	1548	21	.	.	PUNCT
admet-2043	1549	1	towards	towards	ADP
admet-2043	1549	2	nanomedicines	nanomedicine	NOUN
admet-2043	1549	3	for	for	ADP
admet-2043	1549	4	neuroaids	neuroaid	NOUN
admet-2043	1549	5	.	.	PUNCT
admet-2043	1550	1	reviews	review	NOUN
admet-2043	1550	2	in	in	ADP
admet-2043	1550	3	medical	medical	ADJ
admet-2043	1550	4	virology	virology	NOUN
admet-2043	1550	5	24	24	NUM
admet-2043	1550	6	(	(	PUNCT
admet-2043	1550	7	2014	2014	NUM
admet-2043	1550	8	)	)	PUNCT
admet-2043	1550	9	103	103	NUM
admet-2043	1550	10	-	-	SYM
admet-2043	1550	11	124	124	NUM
admet-2043	1550	12	.	.	PUNCT
admet-2043	1551	1	https://doi.org/10.1002/rmv.1778	https://doi.org/10.1002/rmv.1778	PROPN
admet-2043	1551	2	.	.	PUNCT
admet-2043	1552	1	[	[	X
admet-2043	1552	2	204	204	NUM
admet-2043	1552	3	]	]	PUNCT
admet-2043	1552	4	e.	e.	PROPN
admet-2043	1552	5	acosta	acosta	PROPN
admet-2043	1552	6	.	.	PUNCT
admet-2043	1553	1	bioavailability	bioavailability	NOUN
admet-2043	1553	2	of	of	ADP
admet-2043	1553	3	nanoparticles	nanoparticle	NOUN
admet-2043	1553	4	in	in	ADP
admet-2043	1553	5	nutrient	nutrient	NOUN
admet-2043	1553	6	and	and	CCONJ
admet-2043	1553	7	nutraceutical	nutraceutical	ADJ
admet-2043	1553	8	delivery	delivery	NOUN
admet-2043	1553	9	.	.	PUNCT
admet-2043	1554	1	current	current	ADJ
admet-2043	1554	2	opinion	opinion	NOUN
admet-2043	1554	3	in	in	ADP
admet-2043	1554	4	colloid	colloid	PROPN
admet-2043	1554	5	&	&	CCONJ
admet-2043	1554	6	interface	interface	PROPN
admet-2043	1554	7	science	science	NOUN
admet-2043	1554	8	14	14	NUM
admet-2043	1554	9	(	(	PUNCT
admet-2043	1554	10	2009	2009	NUM
admet-2043	1554	11	)	)	PUNCT
admet-2043	1554	12	3	3	NUM
admet-2043	1554	13	-	-	SYM
admet-2043	1554	14	15	15	NUM
admet-2043	1554	15	.	.	PUNCT
admet-2043	1555	1	https://doi.org/10.1016/j.cocis.2008.01.002	https://doi.org/10.1016/j.cocis.2008.01.002	PRON
admet-2043	1555	2	.	.	PUNCT
admet-2043	1556	1	[	[	X
admet-2043	1556	2	205	205	NUM
admet-2043	1556	3	]	]	X
admet-2043	1556	4	d.j	d.j	PROPN
admet-2043	1556	5	.	.	PROPN
admet-2043	1556	6	mcclements	mcclements	PROPN
admet-2043	1556	7	,	,	PUNCT
admet-2043	1556	8	f.	f.	PROPN
admet-2043	1556	9	li	li	PROPN
admet-2043	1556	10	,	,	PUNCT
admet-2043	1556	11	h.	h.	PROPN
admet-2043	1556	12	xiao	xiao	PROPN
admet-2043	1556	13	.	.	PUNCT
admet-2043	1557	1	the	the	DET
admet-2043	1557	2	nutraceutical	nutraceutical	ADJ
admet-2043	1557	3	bioavailability	bioavailability	NOUN
admet-2043	1557	4	classification	classification	NOUN
admet-2043	1557	5	scheme	scheme	NOUN
admet-2043	1557	6	:	:	PUNCT
admet-2043	1557	7	classifying	classify	VERB
admet-2043	1557	8	nutraceuticals	nutraceutical	NOUN
admet-2043	1557	9	according	accord	VERB
admet-2043	1557	10	to	to	ADP
admet-2043	1557	11	factors	factor	NOUN
admet-2043	1557	12	limiting	limit	VERB
admet-2043	1557	13	their	their	PRON
admet-2043	1557	14	oral	oral	ADJ
admet-2043	1557	15	bioavailability	bioavailability	NOUN
admet-2043	1557	16	.	.	PUNCT
admet-2043	1558	1	annual	annual	ADJ
admet-2043	1558	2	review	review	NOUN
admet-2043	1558	3	of	of	ADP
admet-2043	1558	4	food	food	NOUN
admet-2043	1558	5	science	science	NOUN
admet-2043	1558	6	and	and	CCONJ
admet-2043	1558	7	technology	technology	NOUN
admet-2043	1558	8	6	6	NUM
admet-2043	1558	9	(	(	PUNCT
admet-2043	1558	10	2015	2015	NUM
admet-2043	1558	11	)	)	PUNCT
admet-2043	1558	12	299	299	NUM
admet-2043	1558	13	-	-	SYM
admet-2043	1558	14	327	327	NUM
admet-2043	1558	15	.	.	PUNCT
admet-2043	1559	1	https://doi.org/10.1146/annurev-food-032814-014043	https://doi.org/10.1146/annurev-food-032814-014043	NOUN
admet-2043	1559	2	.	.	PUNCT
admet-2043	1560	1	[	[	X
admet-2043	1560	2	206	206	NUM
admet-2043	1560	3	]	]	X
admet-2043	1560	4	w.g	w.g	PROPN
admet-2043	1560	5	.	.	PROPN
admet-2043	1560	6	kreyling	kreyling	PROPN
admet-2043	1560	7	,	,	PUNCT
admet-2043	1560	8	a.m.	a.m.	NOUN
admet-2043	1560	9	abdelmonem	abdelmonem	PROPN
admet-2043	1560	10	,	,	PUNCT
admet-2043	1560	11	z.	z.	PROPN
admet-2043	1560	12	ali	ali	PROPN
admet-2043	1560	13	,	,	PUNCT
admet-2043	1560	14	f.	f.	PROPN
admet-2043	1560	15	alves	alves	PROPN
admet-2043	1560	16	,	,	PUNCT
admet-2043	1560	17	m.	m.	NOUN
admet-2043	1560	18	geiser	geiser	PROPN
admet-2043	1560	19	,	,	PUNCT
admet-2043	1560	20	n.	n.	PROPN
admet-2043	1560	21	haberl	haberl	PROPN
admet-2043	1560	22	,	,	PUNCT
admet-2043	1560	23	r.	r.	PROPN
admet-2043	1560	24	hartmann	hartmann	PROPN
admet-2043	1560	25	,	,	PUNCT
admet-2043	1560	26	s.	s.	PROPN
admet-2043	1560	27	hirn	hirn	PROPN
admet-2043	1560	28	,	,	PUNCT
admet-2043	1560	29	d.j	d.j	PROPN
admet-2043	1560	30	.	.	PROPN
admet-2043	1560	31	de	de	PROPN
admet-2043	1560	32	aberasturi	aberasturi	PROPN
admet-2043	1560	33	,	,	PUNCT
admet-2043	1560	34	k.	k.	PROPN
admet-2043	1560	35	kantner	kantner	PROPN
admet-2043	1560	36	,	,	PUNCT
admet-2043	1560	37	g.	g.	PROPN
admet-2043	1560	38	khadem	khadem	PROPN
admet-2043	1560	39	-	-	PUNCT
admet-2043	1560	40	saba	saba	PROPN
admet-2043	1560	41	,	,	PUNCT
admet-2043	1560	42	j.m	j.m	PROPN
admet-2043	1560	43	.	.	PROPN
admet-2043	1560	44	montenegro	montenegro	PROPN
admet-2043	1560	45	,	,	PUNCT
admet-2043	1560	46	j.	j.	PROPN
admet-2043	1560	47	rejman	rejman	PROPN
admet-2043	1560	48	,	,	PUNCT
admet-2043	1560	49	t.	t.	PROPN
admet-2043	1560	50	rojo	rojo	PROPN
admet-2043	1560	51	,	,	PUNCT
admet-2043	1560	52	i.r	i.r	PROPN
admet-2043	1560	53	.	.	PROPN
admet-2043	1560	54	de	de	X
admet-2043	1560	55	larramendi	larramendi	PROPN
admet-2043	1560	56	,	,	PUNCT
admet-2043	1560	57	r.	r.	PROPN
admet-2043	1560	58	ufartes	ufarte	NOUN
admet-2043	1560	59	,	,	PUNCT
admet-2043	1560	60	a.	a.	PROPN
admet-2043	1560	61	wenk	wenk	PROPN
admet-2043	1560	62	,	,	PUNCT
admet-2043	1560	63	w.j	w.j	PROPN
admet-2043	1560	64	.	.	PROPN
admet-2043	1560	65	parak	parak	PROPN
admet-2043	1560	66	.	.	PUNCT
admet-2043	1561	1	in	in	ADP
admet-2043	1561	2	vivo	vivo	ADJ
admet-2043	1561	3	integrity	integrity	NOUN
admet-2043	1561	4	of	of	ADP
admet-2043	1561	5	polymer	polymer	NOUN
admet-2043	1561	6	-	-	PUNCT
admet-2043	1561	7	coated	coat	VERB
admet-2043	1561	8	gold	gold	NOUN
admet-2043	1561	9	nanoparticles	nanoparticle	NOUN
admet-2043	1561	10	.	.	PUNCT
admet-2043	1562	1	nature	nature	NOUN
admet-2043	1562	2	nanotechnology	nanotechnology	PROPN
admet-2043	1562	3	10	10	NUM
admet-2043	1562	4	(	(	PUNCT
admet-2043	1562	5	2015	2015	NUM
admet-2043	1562	6	)	)	PUNCT
admet-2043	1562	7	619	619	NUM
admet-2043	1562	8	-	-	SYM
admet-2043	1562	9	623	623	NUM
admet-2043	1562	10	.	.	PUNCT
admet-2043	1563	1	https://doi.org/10.1038/nnano.2015.111	https://doi.org/10.1038/nnano.2015.111	NOUN
admet-2043	1563	2	.	.	PUNCT
admet-2043	1564	1	[	[	X
admet-2043	1564	2	207	207	NUM
admet-2043	1564	3	]	]	X
admet-2043	1564	4	f.	f.	PROPN
admet-2043	1564	5	chen	chen	PROPN
admet-2043	1564	6	,	,	PUNCT
admet-2043	1564	7	g.	g.	PROPN
admet-2043	1564	8	wang	wang	PROPN
admet-2043	1564	9	,	,	PUNCT
admet-2043	1564	10	j.i	j.i	PROPN
admet-2043	1564	11	.	.	PROPN
admet-2043	1564	12	griffin	griffin	PROPN
admet-2043	1564	13	,	,	PUNCT
admet-2043	1564	14	b.	b.	PROPN
admet-2043	1564	15	brenneman	brenneman	PROPN
admet-2043	1564	16	,	,	PUNCT
admet-2043	1564	17	n.k	n.k	PROPN
admet-2043	1564	18	.	.	PROPN
admet-2043	1564	19	banda	banda	NOUN
admet-2043	1564	20	,	,	PUNCT
admet-2043	1564	21	v.m	v.m	PROPN
admet-2043	1564	22	.	.	PROPN
admet-2043	1564	23	holers	holers	PROPN
admet-2043	1564	24	,	,	PUNCT
admet-2043	1564	25	d.s	d.s	PROPN
admet-2043	1564	26	.	.	PROPN
admet-2043	1564	27	backos	backos	PROPN
admet-2043	1564	28	,	,	PUNCT
admet-2043	1564	29	l.	l.	PROPN
admet-2043	1564	30	wu	wu	PROPN
admet-2043	1564	31	,	,	PUNCT
admet-2043	1564	32	s.m	s.m	PROPN
admet-2043	1564	33	.	.	PROPN
admet-2043	1564	34	moghimi	moghimi	PROPN
admet-2043	1564	35	,	,	PUNCT
admet-2043	1564	36	d.	d.	PROPN
admet-2043	1564	37	simberg	simberg	PROPN
admet-2043	1564	38	.	.	PUNCT
admet-2043	1565	1	complement	complement	NOUN
admet-2043	1565	2	proteins	protein	NOUN
admet-2043	1565	3	bind	bind	VERB
admet-2043	1565	4	to	to	PART
admet-2043	1565	5	nanoparticle	nanoparticle	VERB
admet-2043	1565	6	protein	protein	NOUN
admet-2043	1565	7	corona	corona	NOUN
admet-2043	1565	8	and	and	CCONJ
admet-2043	1565	9	undergo	undergo	VERB
admet-2043	1565	10	dynamic	dynamic	ADJ
admet-2043	1565	11	exchange	exchange	NOUN
admet-2043	1565	12	in	in	ADP
admet-2043	1565	13	vivo	vivo	NOUN
admet-2043	1565	14	.	.	PUNCT
admet-2043	1566	1	nature	nature	PROPN
admet-2043	1566	2	nanotechnology	nanotechnology	PROPN
admet-2043	1566	3	12	12	NUM
admet-2043	1566	4	(	(	PUNCT
admet-2043	1566	5	2017	2017	NUM
admet-2043	1566	6	)	)	PUNCT
admet-2043	1566	7	387	387	NUM
admet-2043	1566	8	-	-	SYM
admet-2043	1566	9	393	393	NUM
admet-2043	1566	10	.	.	PUNCT
admet-2043	1567	1	https://doi.org/10.1038/nnano.2016.269	https://doi.org/10.1038/nnano.2016.269	NOUN
admet-2043	1567	2	.	.	PUNCT
admet-2043	1568	1	[	[	X
admet-2043	1568	2	208	208	NUM
admet-2043	1568	3	]	]	X
admet-2043	1568	4	f.	f.	PROPN
admet-2043	1568	5	sartain	sartain	PROPN
admet-2043	1568	6	,	,	PUNCT
admet-2043	1568	7	f.	f.	PROPN
admet-2043	1568	8	greco	greco	PROPN
admet-2043	1568	9	,	,	PUNCT
admet-2043	1568	10	k.	k.	PROPN
admet-2043	1568	11	hill	hill	PROPN
admet-2043	1568	12	,	,	PUNCT
admet-2043	1568	13	s.	s.	PROPN
admet-2043	1568	14	rannard	rannard	PROPN
admet-2043	1568	15	,	,	PUNCT
admet-2043	1568	16	a.	a.	PROPN
admet-2043	1568	17	owen	owen	PROPN
admet-2043	1568	18	.	.	PUNCT
admet-2043	1569	1	emerging	emerge	VERB
admet-2043	1569	2	nanomedicine	nanomedicine	ADJ
admet-2043	1569	3	applications	application	NOUN
admet-2043	1569	4	and	and	CCONJ
admet-2043	1569	5	manufacturing	manufacturing	NOUN
admet-2043	1569	6	:	:	PUNCT
admet-2043	1569	7	progress	progress	NOUN
admet-2043	1569	8	and	and	CCONJ
admet-2043	1569	9	challenges	challenge	NOUN
admet-2043	1569	10	.	.	PUNCT
admet-2043	1570	1	nanomedicine	nanomedicine	NOUN
admet-2043	1570	2	(	(	PUNCT
admet-2043	1570	3	lond	lond	ADJ
admet-2043	1570	4	)	)	PUNCT
admet-2043	1570	5	11	11	NUM
admet-2043	1570	6	(	(	PUNCT
admet-2043	1570	7	2016	2016	NUM
admet-2043	1570	8	)	)	PUNCT
admet-2043	1570	9	577	577	NUM
admet-2043	1570	10	-	-	SYM
admet-2043	1570	11	580	580	NUM
admet-2043	1570	12	.	.	PUNCT
admet-2043	1571	1	https://doi.org/10.2217/nnm.16.17	https://doi.org/10.2217/nnm.16.17	PROPN
admet-2043	1571	2	.	.	PUNCT
admet-2043	1572	1	https://doi.org/10.3389/fphar.2021.612659	https://doi.org/10.3389/fphar.2021.612659	PROPN
admet-2043	1572	2	https://doi.org/10.2217/17435889.3.6.859	https://doi.org/10.2217/17435889.3.6.859	PROPN
admet-2043	1572	3	https://doi.org/10.1016/j.addr.2019.06.003	https://doi.org/10.1016/j.addr.2019.06.003	PROPN
admet-2043	1572	4	https://doi.org/10.1016/j.tibtech.2016.07.006	https://doi.org/10.1016/j.tibtech.2016.07.006	PROPN
admet-2043	1572	5	https://doi.org/10.1007/s11095-010-0233-4	https://doi.org/10.1007/s11095-010-0233-4	PROPN
admet-2043	1572	6	https://doi.org/10.4155/tde.13.135	https://doi.org/10.4155/tde.13.135	PRON
admet-2043	1572	7	https://doi.org/10.1023/a:1020398624602	https://doi.org/10.1023/a:1020398624602	VERB
admet-2043	1572	8	https://doi.org/10.2217/nnm.14.130	https://doi.org/10.2217/nnm.14.130	ADP
admet-2043	1572	9	https://doi.org/10.1039/c6nr06728j	https://doi.org/10.1039/c6nr06728j	PROPN
admet-2043	1572	10	https://doi.org/10.2174/138920012802850128	https://doi.org/10.2174/138920012802850128	NOUN
admet-2043	1572	11	https://doi.org/10.1039/c3an36705c	https://doi.org/10.1039/c3an36705c	X
admet-2043	1573	1	https://doi.org/10.1016/s0377-1237(06)80016-x	https://doi.org/10.1016/s0377-1237(06)80016-x	PROPN
admet-2043	1573	2	https://doi.org/10.1002/rmv.1778	https://doi.org/10.1002/rmv.1778	NOUN
admet-2043	1573	3	https://doi.org/10.1016/j.cocis.2008.01.002	https://doi.org/10.1016/j.cocis.2008.01.002	PROPN
admet-2043	1573	4	https://doi.org/10.1146/annurev-food-032814-014043	https://doi.org/10.1146/annurev-food-032814-014043	PROPN
admet-2043	1573	5	https://doi.org/10.1038/nnano.2015.111	https://doi.org/10.1038/nnano.2015.111	PROPN
admet-2043	1573	6	https://doi.org/10.1038/nnano.2016.269	https://doi.org/10.1038/nnano.2016.269	NOUN
admet-2043	1573	7	https://doi.org/10.2217/nnm.16.17	https://doi.org/10.2217/nnm.16.17	X
admet-2043	1573	8	admet	admet	PROPN
admet-2043	1573	9	&	&	CCONJ
admet-2043	1573	10	dmpk	dmpk	PROPN
admet-2043	1573	11	12(1	12(1	PROPN
admet-2043	1573	12	)	)	PUNCT
admet-2043	1573	13	(	(	PUNCT
admet-2043	1573	14	2024	2024	NUM
admet-2043	1573	15	)	)	PUNCT
admet-2043	1573	16	63	63	NUM
admet-2043	1573	17	-	-	SYM
admet-2043	1573	18	105	105	NUM
admet-2043	1573	19	nanomaterials	nanomaterial	NOUN
admet-2043	1573	20	as	as	ADP
admet-2043	1573	21	drug	drug	NOUN
admet-2043	1573	22	delivery	delivery	NOUN
admet-2043	1573	23	agents	agent	NOUN
admet-2043	1573	24	for	for	ADP
admet-2043	1573	25	overcoming	overcome	VERB
admet-2043	1573	26	bbb	bbb	PROPN
admet-2043	1573	27	doi	doi	NOUN
admet-2043	1573	28	:	:	PUNCT
admet-2043	1573	29	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1573	30	105	105	NUM
admet-2043	1573	31	[	[	X
admet-2043	1573	32	209	209	NUM
admet-2043	1573	33	]	]	X
admet-2043	1573	34	h.l	h.l	PROPN
admet-2043	1573	35	.	.	PROPN
admet-2043	1573	36	jang	jang	PROPN
admet-2043	1573	37	,	,	PUNCT
admet-2043	1573	38	y.s	y.s	PROPN
admet-2043	1573	39	.	.	PROPN
admet-2043	1573	40	zhang	zhang	PROPN
admet-2043	1573	41	,	,	PUNCT
admet-2043	1573	42	a.	a.	NOUN
admet-2043	1573	43	khademhosseini	khademhosseini	PROPN
admet-2043	1573	44	.	.	PUNCT
admet-2043	1574	1	boosting	boost	VERB
admet-2043	1574	2	clinical	clinical	ADJ
admet-2043	1574	3	translation	translation	NOUN
admet-2043	1574	4	of	of	ADP
admet-2043	1574	5	nanomedicine	nanomedicine	PROPN
admet-2043	1574	6	.	.	PUNCT
admet-2043	1575	1	nanomedicine	nanomedicine	PROPN
admet-2043	1575	2	(	(	PUNCT
admet-2043	1575	3	lond	lond	ADJ
admet-2043	1575	4	)	)	PUNCT
admet-2043	1575	5	11	11	NUM
admet-2043	1575	6	(	(	PUNCT
admet-2043	1575	7	2016	2016	NUM
admet-2043	1575	8	)	)	PUNCT
admet-2043	1575	9	1495	1495	NUM
admet-2043	1575	10	-	-	SYM
admet-2043	1575	11	1497	1497	NUM
admet-2043	1575	12	.	.	PUNCT
admet-2043	1576	1	https://doi.org/10.2217/nnm-2016-0133	https://doi.org/10.2217/nnm-2016-0133	NOUN
admet-2043	1576	2	.	.	PUNCT
admet-2043	1577	1	[	[	X
admet-2043	1577	2	210	210	NUM
admet-2043	1577	3	]	]	X
admet-2043	1577	4	j.i	j.i	PROPN
admet-2043	1577	5	.	.	PROPN
admet-2043	1577	6	hare	hare	PROPN
admet-2043	1577	7	,	,	PUNCT
admet-2043	1577	8	t.	t.	PROPN
admet-2043	1577	9	lammers	lammers	PROPN
admet-2043	1577	10	,	,	PUNCT
admet-2043	1577	11	m.b	m.b	PROPN
admet-2043	1577	12	.	.	PROPN
admet-2043	1577	13	ashford	ashford	PROPN
admet-2043	1577	14	,	,	PUNCT
admet-2043	1577	15	s.	s.	PROPN
admet-2043	1577	16	puri	puri	PROPN
admet-2043	1577	17	,	,	PUNCT
admet-2043	1577	18	g.	g.	PROPN
admet-2043	1577	19	storm	storm	PROPN
admet-2043	1577	20	,	,	PUNCT
admet-2043	1577	21	s.t	s.t	PROPN
admet-2043	1577	22	.	.	PROPN
admet-2043	1577	23	barry	barry	PROPN
admet-2043	1577	24	.	.	PUNCT
admet-2043	1578	1	challenges	challenge	NOUN
admet-2043	1578	2	and	and	CCONJ
admet-2043	1578	3	strategies	strategy	NOUN
admet-2043	1578	4	in	in	ADP
admet-2043	1578	5	anticancer	anticancer	NOUN
admet-2043	1578	6	nanomedicine	nanomedicine	ADJ
admet-2043	1578	7	development	development	NOUN
admet-2043	1578	8	:	:	PUNCT
admet-2043	1578	9	an	an	DET
admet-2043	1578	10	industry	industry	NOUN
admet-2043	1578	11	perspective	perspective	NOUN
admet-2043	1578	12	.	.	PUNCT
admet-2043	1579	1	advanced	advanced	ADJ
admet-2043	1579	2	drug	drug	NOUN
admet-2043	1579	3	delivery	delivery	NOUN
admet-2043	1579	4	reviews	review	NOUN
admet-2043	1579	5	108	108	NUM
admet-2043	1579	6	(	(	PUNCT
admet-2043	1579	7	2017	2017	NUM
admet-2043	1579	8	)	)	PUNCT
admet-2043	1579	9	25	25	NUM
admet-2043	1579	10	-	-	SYM
admet-2043	1579	11	38	38	NUM
admet-2043	1579	12	.	.	PUNCT
admet-2043	1580	1	[	[	X
admet-2043	1580	2	211	211	NUM
admet-2043	1580	3	]	]	PUNCT
admet-2043	1580	4	r.	r.	PROPN
admet-2043	1580	5	liu	liu	PROPN
admet-2043	1580	6	,	,	PUNCT
admet-2043	1580	7	c.	c.	PROPN
admet-2043	1580	8	luo	luo	PROPN
admet-2043	1580	9	,	,	PUNCT
admet-2043	1580	10	z.	z.	PROPN
admet-2043	1580	11	pang	pang	PROPN
admet-2043	1580	12	,	,	PUNCT
admet-2043	1580	13	j.	j.	PROPN
admet-2043	1580	14	zhang	zhang	PROPN
admet-2043	1580	15	,	,	PUNCT
admet-2043	1580	16	s.	s.	PROPN
admet-2043	1580	17	ruan	ruan	PROPN
admet-2043	1580	18	,	,	PUNCT
admet-2043	1580	19	m.	m.	PROPN
admet-2043	1580	20	wu	wu	PROPN
admet-2043	1580	21	,	,	PUNCT
admet-2043	1580	22	l.	l.	PROPN
admet-2043	1580	23	wang	wang	PROPN
admet-2043	1580	24	,	,	PUNCT
admet-2043	1580	25	t.	t.	PROPN
admet-2043	1580	26	sun	sun	PROPN
admet-2043	1580	27	,	,	PUNCT
admet-2043	1580	28	n.	n.	PROPN
admet-2043	1580	29	li	li	PROPN
admet-2043	1580	30	,	,	PUNCT
admet-2043	1580	31	l.	l.	PROPN
admet-2043	1580	32	han	han	PROPN
admet-2043	1580	33	,	,	PUNCT
admet-2043	1580	34	j.	j.	PROPN
admet-2043	1580	35	shi	shi	PROPN
admet-2043	1580	36	,	,	PUNCT
admet-2043	1580	37	y.	y.	PROPN
admet-2043	1580	38	huang	huang	PROPN
admet-2043	1580	39	,	,	PUNCT
admet-2043	1580	40	w.	w.	PROPN
admet-2043	1580	41	guo	guo	PROPN
admet-2043	1580	42	,	,	PUNCT
admet-2043	1580	43	s.	s.	PROPN
admet-2043	1580	44	peng	peng	PROPN
admet-2043	1580	45	,	,	PUNCT
admet-2043	1580	46	w.	w.	PROPN
admet-2043	1580	47	zhou	zhou	PROPN
admet-2043	1580	48	,	,	PUNCT
admet-2043	1580	49	h.	h.	PROPN
admet-2043	1580	50	gao	gao	PROPN
admet-2043	1580	51	.	.	PUNCT
admet-2043	1580	52	advances	advance	NOUN
admet-2043	1580	53	of	of	ADP
admet-2043	1580	54	nanoparticles	nanoparticle	NOUN
admet-2043	1580	55	as	as	ADP
admet-2043	1580	56	drug	drug	NOUN
admet-2043	1580	57	delivery	delivery	NOUN
admet-2043	1580	58	systems	system	NOUN
admet-2043	1580	59	for	for	ADP
admet-2043	1580	60	disease	disease	NOUN
admet-2043	1580	61	diagnosis	diagnosis	NOUN
admet-2043	1580	62	and	and	CCONJ
admet-2043	1580	63	treatment	treatment	NOUN
admet-2043	1580	64	.	.	PUNCT
admet-2043	1581	1	chinese	chinese	ADJ
admet-2043	1581	2	chemical	chemical	PROPN
admet-2043	1581	3	letters	letter	NOUN
admet-2043	1581	4	34	34	NUM
admet-2043	1581	5	(	(	PUNCT
admet-2043	1581	6	2023	2023	NUM
admet-2043	1581	7	)	)	PUNCT
admet-2043	1581	8	107518	107518	NUM
admet-2043	1581	9	.	.	PUNCT
admet-2043	1582	1	https://doi.org/10.1016/j.cclet.2022.05.032	https://doi.org/10.1016/j.cclet.2022.05.032	PRON
admet-2043	1582	2	.	.	PUNCT
admet-2043	1583	1	[	[	X
admet-2043	1583	2	212	212	NUM
admet-2043	1583	3	]	]	X
admet-2043	1583	4	r.i	r.i	PROPN
admet-2043	1583	5	.	.	PROPN
admet-2043	1583	6	teleanu	teleanu	PROPN
admet-2043	1583	7	,	,	PUNCT
admet-2043	1583	8	m.d	m.d	PROPN
admet-2043	1583	9	.	.	PROPN
admet-2043	1583	10	preda	preda	PROPN
admet-2043	1583	11	,	,	PUNCT
admet-2043	1583	12	a.g	a.g	PROPN
admet-2043	1583	13	.	.	PROPN
admet-2043	1583	14	niculescu	niculescu	PROPN
admet-2043	1583	15	,	,	PUNCT
admet-2043	1583	16	o.	o.	PROPN
admet-2043	1583	17	vladacenco	vladacenco	PROPN
admet-2043	1583	18	,	,	PUNCT
admet-2043	1583	19	c.i	c.i	PROPN
admet-2043	1583	20	.	.	PROPN
admet-2043	1583	21	radu	radu	PROPN
admet-2043	1583	22	,	,	PUNCT
admet-2043	1583	23	a.m.	a.m.	PROPN
admet-2043	1583	24	grumezescu	grumezescu	PROPN
admet-2043	1583	25	,	,	PUNCT
admet-2043	1583	26	d.m	d.m	PROPN
admet-2043	1583	27	.	.	PROPN
admet-2043	1583	28	teleanu	teleanu	PROPN
admet-2043	1583	29	.	.	PUNCT
admet-2043	1584	1	current	current	ADJ
admet-2043	1584	2	strategies	strategy	NOUN
admet-2043	1584	3	to	to	PART
admet-2043	1584	4	enhance	enhance	VERB
admet-2043	1584	5	delivery	delivery	NOUN
admet-2043	1584	6	of	of	ADP
admet-2043	1584	7	drugs	drug	NOUN
admet-2043	1584	8	across	across	ADP
admet-2043	1584	9	the	the	DET
admet-2043	1584	10	blood	blood	NOUN
admet-2043	1584	11	-	-	PUNCT
admet-2043	1584	12	brain	brain	NOUN
admet-2043	1584	13	barrier	barrier	NOUN
admet-2043	1584	14	.	.	PUNCT
admet-2043	1585	1	pharmaceutics	pharmaceutic	NOUN
admet-2043	1585	2	14	14	NUM
admet-2043	1585	3	(	(	PUNCT
admet-2043	1585	4	2022	2022	NUM
admet-2043	1585	5	)	)	PUNCT
admet-2043	1585	6	987	987	NUM
admet-2043	1585	7	.	.	PUNCT
admet-2043	1586	1	https://doi.org/10.3390/pharmaceutics14050987	https://doi.org/10.3390/pharmaceutics14050987	NOUN
admet-2043	1586	2	.	.	PUNCT
admet-2043	1587	1	[	[	X
admet-2043	1587	2	213	213	NUM
admet-2043	1587	3	]	]	X
admet-2043	1587	4	d.	d.	PROPN
admet-2043	1587	5	ho	ho	PROPN
admet-2043	1587	6	,	,	PUNCT
admet-2043	1587	7	s.r	s.r	PROPN
admet-2043	1587	8	.	.	PROPN
admet-2043	1587	9	quake	quake	NOUN
admet-2043	1587	10	,	,	PUNCT
admet-2043	1587	11	e.r.b	e.r.b	PROPN
admet-2043	1587	12	.	.	PUNCT
admet-2043	1587	13	mccabe	mccabe	PROPN
admet-2043	1587	14	,	,	PUNCT
admet-2043	1587	15	w.j	w.j	PROPN
admet-2043	1587	16	.	.	PROPN
admet-2043	1587	17	chng	chng	PROPN
admet-2043	1587	18	,	,	PUNCT
admet-2043	1587	19	e.k	e.k	PROPN
admet-2043	1587	20	.	.	PROPN
admet-2043	1587	21	chow	chow	PROPN
admet-2043	1587	22	,	,	PUNCT
admet-2043	1587	23	x.	x.	PROPN
admet-2043	1587	24	ding	ding	PROPN
admet-2043	1587	25	,	,	PUNCT
admet-2043	1587	26	b.d	b.d	PROPN
admet-2043	1587	27	.	.	PROPN
admet-2043	1587	28	gelb	gelb	PROPN
admet-2043	1587	29	,	,	PUNCT
admet-2043	1587	30	g.s	g.s	PROPN
admet-2043	1587	31	.	.	PROPN
admet-2043	1587	32	ginsburg	ginsburg	PROPN
admet-2043	1587	33	,	,	PUNCT
admet-2043	1587	34	j.	j.	PROPN
admet-2043	1587	35	hassenstab	hassenstab	PROPN
admet-2043	1587	36	,	,	PUNCT
admet-2043	1587	37	c.m	c.m	PROPN
admet-2043	1587	38	.	.	PROPN
admet-2043	1587	39	ho	ho	PROPN
admet-2043	1587	40	,	,	PUNCT
admet-2043	1587	41	w.c	w.c	PROPN
admet-2043	1587	42	.	.	PROPN
admet-2043	1587	43	mobley	mobley	PROPN
admet-2043	1587	44	,	,	PUNCT
admet-2043	1587	45	g.p	g.p	PROPN
admet-2043	1587	46	.	.	PROPN
admet-2043	1587	47	nolan	nolan	PROPN
admet-2043	1587	48	,	,	PUNCT
admet-2043	1587	49	s.t	s.t	PROPN
admet-2043	1587	50	.	.	PROPN
admet-2043	1587	51	rosen	rosen	PROPN
admet-2043	1587	52	,	,	PUNCT
admet-2043	1587	53	p.	p.	PROPN
admet-2043	1587	54	tan	tan	PROPN
admet-2043	1587	55	,	,	PUNCT
admet-2043	1587	56	y.	y.	PROPN
admet-2043	1587	57	yen	yen	PROPN
admet-2043	1587	58	,	,	PUNCT
admet-2043	1587	59	a.	a.	NOUN
admet-2043	1587	60	zarrinpar	zarrinpar	PROPN
admet-2043	1587	61	.	.	PUNCT
admet-2043	1588	1	enabling	enable	VERB
admet-2043	1588	2	technologies	technology	NOUN
admet-2043	1588	3	for	for	ADP
admet-2043	1588	4	personalized	personalized	ADJ
admet-2043	1588	5	and	and	CCONJ
admet-2043	1588	6	precision	precision	NOUN
admet-2043	1588	7	medicine	medicine	NOUN
admet-2043	1588	8	.	.	PUNCT
admet-2043	1589	1	trends	trend	NOUN
admet-2043	1589	2	in	in	ADP
admet-2043	1589	3	biotechnology	biotechnology	NOUN
admet-2043	1589	4	38	38	NUM
admet-2043	1589	5	(	(	PUNCT
admet-2043	1589	6	2020	2020	NUM
admet-2043	1589	7	)	)	PUNCT
admet-2043	1589	8	497	497	NUM
admet-2043	1589	9	-	-	SYM
admet-2043	1589	10	518	518	NUM
admet-2043	1589	11	.	.	PUNCT
admet-2043	1590	1	https://doi.org/10.1016/j.tibtech.2019.12.021	https://doi.org/10.1016/j.tibtech.2019.12.021	NOUN
admet-2043	1590	2	.	.	PUNCT
admet-2043	1591	1	[	[	X
admet-2043	1591	2	214	214	X
admet-2043	1591	3	]	]	X
admet-2043	1591	4	r.k	r.k	PROPN
admet-2043	1591	5	.	.	PROPN
admet-2043	1591	6	tekade	tekade	PROPN
admet-2043	1591	7	,	,	PUNCT
admet-2043	1591	8	r.	r.	PROPN
admet-2043	1591	9	maheshwari	maheshwari	PROPN
admet-2043	1591	10	,	,	PUNCT
admet-2043	1591	11	n.	n.	PROPN
admet-2043	1591	12	soni	soni	PROPN
admet-2043	1591	13	,	,	PUNCT
admet-2043	1591	14	m.	m.	NOUN
admet-2043	1591	15	tekade	tekade	PROPN
admet-2043	1591	16	,	,	PUNCT
admet-2043	1591	17	m.b	m.b	PROPN
admet-2043	1591	18	.	.	PROPN
admet-2043	1591	19	chougule	chougule	NOUN
admet-2043	1591	20	,	,	PUNCT
admet-2043	1591	21	nanotechnology	nanotechnology	NOUN
admet-2043	1591	22	for	for	ADP
admet-2043	1591	23	the	the	DET
admet-2043	1591	24	development	development	NOUN
admet-2043	1591	25	of	of	ADP
admet-2043	1591	26	nanomedicine	nanomedicine	NOUN
admet-2043	1591	27	,	,	PUNCT
admet-2043	1591	28	in	in	ADP
admet-2043	1591	29	nanotechnology	nanotechnology	NOUN
admet-2043	1591	30	-	-	PUNCT
admet-2043	1591	31	based	base	VERB
admet-2043	1591	32	approaches	approach	NOUN
admet-2043	1591	33	for	for	ADP
admet-2043	1591	34	targeting	targeting	NOUN
admet-2043	1591	35	and	and	CCONJ
admet-2043	1591	36	delivery	delivery	NOUN
admet-2043	1591	37	of	of	ADP
admet-2043	1591	38	drugs	drug	NOUN
admet-2043	1591	39	and	and	CCONJ
admet-2043	1591	40	genes	gene	NOUN
admet-2043	1591	41	,	,	PUNCT
admet-2043	1591	42	elsevier2017	elsevier2017	PROPN
admet-2043	1591	43	,	,	PUNCT
admet-2043	1591	44	p.	p.	NOUN
admet-2043	1591	45	3	3	NUM
admet-2043	1591	46	-	-	SYM
admet-2043	1591	47	61	61	NUM
admet-2043	1591	48	9780128097175	9780128097175	NUM
admet-2043	1591	49	.	.	PUNCT
admet-2043	1592	1	https://doi.org/10.1016/b978-0-12809717-5.00001-4	https://doi.org/10.1016/b978-0-12809717-5.00001-4	NOUN
admet-2043	1592	2	.	.	PUNCT
admet-2043	1593	1	[	[	X
admet-2043	1593	2	215	215	NUM
admet-2043	1593	3	]	]	PUNCT
admet-2043	1593	4	b.	b.	PROPN
admet-2043	1593	5	mendoza	mendoza	PROPN
admet-2043	1593	6	-	-	PUNCT
admet-2043	1593	7	sanchez	sanchez	PROPN
admet-2043	1593	8	,	,	PUNCT
admet-2043	1593	9	y.	y.	PROPN
admet-2043	1593	10	gogotsi	gogotsi	PROPN
admet-2043	1593	11	.	.	PUNCT
admet-2043	1594	1	synthesis	synthesis	NOUN
admet-2043	1594	2	of	of	ADP
admet-2043	1594	3	two	two	NUM
admet-2043	1594	4	-	-	PUNCT
admet-2043	1594	5	dimensional	dimensional	ADJ
admet-2043	1594	6	materials	material	NOUN
admet-2043	1594	7	for	for	ADP
admet-2043	1594	8	capacitive	capacitive	ADJ
admet-2043	1594	9	energy	energy	NOUN
admet-2043	1594	10	storage	storage	NOUN
admet-2043	1594	11	.	.	PUNCT
admet-2043	1595	1	advanced	advanced	ADJ
admet-2043	1595	2	materials	material	NOUN
admet-2043	1595	3	28	28	NUM
admet-2043	1595	4	(	(	PUNCT
admet-2043	1595	5	2016	2016	NUM
admet-2043	1595	6	)	)	PUNCT
admet-2043	1595	7	6104	6104	NUM
admet-2043	1595	8	-	-	SYM
admet-2043	1595	9	6135	6135	NUM
admet-2043	1595	10	.	.	PUNCT
admet-2043	1596	1	https://doi.org/10.1002/adma.201506133	https://doi.org/10.1002/adma.201506133	X
admet-2043	1596	2	.	.	PUNCT
admet-2043	1597	1	[	[	X
admet-2043	1597	2	216	216	NUM
admet-2043	1597	3	]	]	PUNCT
admet-2043	1597	4	v.	v.	CCONJ
admet-2043	1597	5	agrahari	agrahari	PROPN
admet-2043	1597	6	,	,	PUNCT
admet-2043	1597	7	v.	v.	ADP
admet-2043	1597	8	agrahari	agrahari	PROPN
admet-2043	1597	9	.	.	PUNCT
admet-2043	1598	1	facilitating	facilitate	VERB
admet-2043	1598	2	the	the	DET
admet-2043	1598	3	translation	translation	NOUN
admet-2043	1598	4	of	of	ADP
admet-2043	1598	5	nanomedicines	nanomedicine	NOUN
admet-2043	1598	6	to	to	ADP
admet-2043	1598	7	a	a	DET
admet-2043	1598	8	clinical	clinical	ADJ
admet-2043	1598	9	product	product	NOUN
admet-2043	1598	10	:	:	PUNCT
admet-2043	1598	11	challenges	challenge	NOUN
admet-2043	1598	12	and	and	CCONJ
admet-2043	1598	13	opportunities	opportunity	NOUN
admet-2043	1598	14	.	.	PUNCT
admet-2043	1599	1	drug	drug	NOUN
admet-2043	1599	2	discovery	discovery	PROPN
admet-2043	1599	3	today	today	NOUN
admet-2043	1599	4	23	23	NUM
admet-2043	1599	5	(	(	PUNCT
admet-2043	1599	6	2018	2018	NUM
admet-2043	1599	7	)	)	PUNCT
admet-2043	1599	8	974	974	NUM
admet-2043	1599	9	-	-	SYM
admet-2043	1599	10	991	991	NUM
admet-2043	1599	11	.	.	PUNCT
admet-2043	1600	1	https://doi.org/10.1016/j.drudis.2018.01.047	https://doi.org/10.1016/j.drudis.2018.01.047	NUM
admet-2043	1600	2	.	.	PUNCT
admet-2043	1601	1	[	[	X
admet-2043	1601	2	217	217	NUM
admet-2043	1601	3	]	]	PUNCT
admet-2043	1601	4	j.	j.	PROPN
admet-2043	1601	5	trienekens	trienekens	PROPN
admet-2043	1601	6	,	,	PUNCT
admet-2043	1601	7	p.	p.	NOUN
admet-2043	1601	8	zuurbier	zuurbier	NOUN
admet-2043	1601	9	.	.	PUNCT
admet-2043	1602	1	quality	quality	NOUN
admet-2043	1602	2	and	and	CCONJ
admet-2043	1602	3	safety	safety	NOUN
admet-2043	1602	4	standards	standard	NOUN
admet-2043	1602	5	in	in	ADP
admet-2043	1602	6	the	the	DET
admet-2043	1602	7	food	food	NOUN
admet-2043	1602	8	industry	industry	NOUN
admet-2043	1602	9	,	,	PUNCT
admet-2043	1602	10	developments	development	NOUN
admet-2043	1602	11	and	and	CCONJ
admet-2043	1602	12	challenges	challenge	NOUN
admet-2043	1602	13	.	.	PUNCT
admet-2043	1603	1	international	international	ADJ
admet-2043	1603	2	journal	journal	PROPN
admet-2043	1603	3	of	of	ADP
admet-2043	1603	4	production	production	NOUN
admet-2043	1603	5	economics	economic	NOUN
admet-2043	1603	6	113	113	NUM
admet-2043	1603	7	(	(	PUNCT
admet-2043	1603	8	2008	2008	NUM
admet-2043	1603	9	)	)	PUNCT
admet-2043	1603	10	107	107	NUM
admet-2043	1603	11	-	-	SYM
admet-2043	1603	12	122	122	NUM
admet-2043	1603	13	.	.	PUNCT
admet-2043	1604	1	https://doi.org/10.1016/j.ijpe.2007.02.050	https://doi.org/10.1016/j.ijpe.2007.02.050	PROPN
admet-2043	1604	2	.	.	PUNCT
admet-2043	1605	1	[	[	X
admet-2043	1605	2	218	218	NUM
admet-2043	1605	3	]	]	PUNCT
admet-2043	1605	4	g.	g.	PROPN
admet-2043	1605	5	reina	reina	PROPN
admet-2043	1605	6	,	,	PUNCT
admet-2043	1605	7	j.m	j.m	PROPN
admet-2043	1605	8	.	.	PROPN
admet-2043	1605	9	gonzalez	gonzalez	PROPN
admet-2043	1605	10	-	-	PUNCT
admet-2043	1605	11	dominguez	dominguez	PROPN
admet-2043	1605	12	,	,	PUNCT
admet-2043	1605	13	a.	a.	NOUN
admet-2043	1605	14	criado	criado	PROPN
admet-2043	1605	15	,	,	PUNCT
admet-2043	1605	16	e.	e.	PROPN
admet-2043	1605	17	vazquez	vazquez	PROPN
admet-2043	1605	18	,	,	PUNCT
admet-2043	1605	19	a.	a.	PROPN
admet-2043	1605	20	bianco	bianco	PROPN
admet-2043	1605	21	,	,	PUNCT
admet-2043	1605	22	m.	m.	NOUN
admet-2043	1605	23	prato	prato	PROPN
admet-2043	1605	24	.	.	PROPN
admet-2043	1605	25	promises	promise	NOUN
admet-2043	1605	26	,	,	PUNCT
admet-2043	1605	27	facts	fact	NOUN
admet-2043	1605	28	and	and	CCONJ
admet-2043	1605	29	challenges	challenge	NOUN
admet-2043	1605	30	for	for	ADP
admet-2043	1605	31	graphene	graphene	NOUN
admet-2043	1605	32	in	in	ADP
admet-2043	1605	33	biomedical	biomedical	ADJ
admet-2043	1605	34	applications	application	NOUN
admet-2043	1605	35	.	.	PUNCT
admet-2043	1606	1	chemical	chemical	PROPN
admet-2043	1606	2	society	society	PROPN
admet-2043	1606	3	reviews	review	VERB
admet-2043	1606	4	46	46	NUM
admet-2043	1606	5	(	(	PUNCT
admet-2043	1606	6	2017	2017	NUM
admet-2043	1606	7	)	)	PUNCT
admet-2043	1606	8	44004416	44004416	NUM
admet-2043	1606	9	.	.	PUNCT
admet-2043	1607	1	https://doi.org/10.1039/c7cs00363c	https://doi.org/10.1039/c7cs00363c	NOUN
admet-2043	1607	2	.	.	PUNCT
admet-2043	1608	1	[	[	X
admet-2043	1608	2	219	219	NUM
admet-2043	1608	3	]	]	PUNCT
admet-2043	1608	4	t.	t.	NOUN
admet-2043	1608	5	bastogne	bastogne	PROPN
admet-2043	1608	6	,	,	PUNCT
admet-2043	1608	7	f.	f.	PROPN
admet-2043	1608	8	caputo	caputo	PROPN
admet-2043	1608	9	,	,	PUNCT
admet-2043	1608	10	a.	a.	PROPN
admet-2043	1608	11	prina	prina	PROPN
admet-2043	1608	12	-	-	PUNCT
admet-2043	1608	13	mello	mello	PROPN
admet-2043	1608	14	,	,	PUNCT
admet-2043	1608	15	s.	s.	PROPN
admet-2043	1608	16	borgos	borgos	PROPN
admet-2043	1608	17	,	,	PUNCT
admet-2043	1608	18	m.	m.	NOUN
admet-2043	1608	19	barberi	barberi	NOUN
admet-2043	1608	20	-	-	PUNCT
admet-2043	1608	21	heyob	heyob	NOUN
admet-2043	1608	22	.	.	PUNCT
admet-2043	1609	1	a	a	DET
admet-2043	1609	2	state	state	NOUN
admet-2043	1609	3	of	of	ADP
admet-2043	1609	4	the	the	DET
admet-2043	1609	5	art	art	NOUN
admet-2043	1609	6	in	in	ADP
admet-2043	1609	7	analytical	analytical	ADJ
admet-2043	1609	8	quality	quality	NOUN
admet-2043	1609	9	-	-	PUNCT
admet-2043	1609	10	by	by	ADP
admet-2043	1609	11	-	-	PUNCT
admet-2043	1609	12	design	design	NOUN
admet-2043	1609	13	and	and	CCONJ
admet-2043	1609	14	perspectives	perspective	NOUN
admet-2043	1609	15	in	in	ADP
admet-2043	1609	16	characterization	characterization	NOUN
admet-2043	1609	17	of	of	ADP
admet-2043	1609	18	nano	nano	NOUN
admet-2043	1609	19	-	-	PUNCT
admet-2043	1609	20	enabled	enable	VERB
admet-2043	1609	21	medicinal	medicinal	ADJ
admet-2043	1609	22	products	product	NOUN
admet-2043	1609	23	.	.	PUNCT
admet-2043	1610	1	journal	journal	NOUN
admet-2043	1610	2	of	of	ADP
admet-2043	1610	3	pharmaceutical	pharmaceutical	NOUN
admet-2043	1610	4	and	and	CCONJ
admet-2043	1610	5	biomedical	biomedical	ADJ
admet-2043	1610	6	analysis	analysis	NOUN
admet-2043	1610	7	219	219	NUM
admet-2043	1610	8	(	(	PUNCT
admet-2043	1610	9	2022	2022	NUM
admet-2043	1610	10	)	)	PUNCT
admet-2043	1610	11	114911	114911	NUM
admet-2043	1610	12	.	.	PUNCT
admet-2043	1611	1	https://doi.org/10.1016/j.jpba.2022.114911	https://doi.org/10.1016/j.jpba.2022.114911	NOUN
admet-2043	1611	2	.	.	PUNCT
admet-2043	1612	1	[	[	X
admet-2043	1612	2	220	220	NUM
admet-2043	1612	3	]	]	PUNCT
admet-2043	1612	4	b.	b.	PROPN
admet-2043	1612	5	yang	yang	PROPN
admet-2043	1612	6	,	,	PUNCT
admet-2043	1612	7	y.	y.	PROPN
admet-2043	1612	8	chen	chen	PROPN
admet-2043	1612	9	,	,	PUNCT
admet-2043	1612	10	j.	j.	PROPN
admet-2043	1612	11	shi	shi	PROPN
admet-2043	1612	12	.	.	PUNCT
admet-2043	1613	1	exosome	exosome	PROPN
admet-2043	1613	2	biochemistry	biochemistry	PROPN
admet-2043	1613	3	and	and	CCONJ
admet-2043	1613	4	advanced	advanced	ADJ
admet-2043	1613	5	nanotechnology	nanotechnology	NOUN
admet-2043	1613	6	for	for	ADP
admet-2043	1613	7	next	next	ADJ
admet-2043	1613	8	-	-	PUNCT
admet-2043	1613	9	generation	generation	NOUN
admet-2043	1613	10	theranostic	theranostic	ADJ
admet-2043	1613	11	platforms	platform	NOUN
admet-2043	1613	12	.	.	PUNCT
admet-2043	1614	1	advanced	advanced	ADJ
admet-2043	1614	2	materials	material	NOUN
admet-2043	1614	3	31	31	NUM
admet-2043	1614	4	(	(	PUNCT
admet-2043	1614	5	2019	2019	NUM
admet-2043	1614	6	)	)	PUNCT
admet-2043	1614	7	e1802896	e1802896	NOUN
admet-2043	1614	8	.	.	PUNCT
admet-2043	1614	9	https://doi.org/10.1002/adma.201802896	https://doi.org/10.1002/adma.201802896	NOUN
admet-2043	1614	10	.	.	PUNCT
admet-2043	1615	1	[	[	X
admet-2043	1615	2	221	221	NUM
admet-2043	1615	3	]	]	PUNCT
admet-2043	1615	4	m.	m.	NOUN
admet-2043	1615	5	rawal	rawal	PROPN
admet-2043	1615	6	,	,	PUNCT
admet-2043	1615	7	a.	a.	PROPN
admet-2043	1615	8	singh	singh	PROPN
admet-2043	1615	9	,	,	PUNCT
admet-2043	1615	10	m.m	m.m	PROPN
admet-2043	1615	11	.	.	PROPN
admet-2043	1615	12	amiji	amiji	PROPN
admet-2043	1615	13	.	.	PUNCT
admet-2043	1616	1	quality	quality	NOUN
admet-2043	1616	2	-	-	PUNCT
admet-2043	1616	3	by	by	ADP
admet-2043	1616	4	-	-	PUNCT
admet-2043	1616	5	design	design	NOUN
admet-2043	1616	6	concepts	concept	NOUN
admet-2043	1616	7	to	to	PART
admet-2043	1616	8	improve	improve	VERB
admet-2043	1616	9	nanotechnology	nanotechnology	NOUN
admet-2043	1616	10	-	-	PUNCT
admet-2043	1616	11	based	base	VERB
admet-2043	1616	12	drug	drug	NOUN
admet-2043	1616	13	development	development	NOUN
admet-2043	1616	14	.	.	PUNCT
admet-2043	1617	1	pharmaceutical	pharmaceutical	PROPN
admet-2043	1617	2	research	research	NOUN
admet-2043	1617	3	36	36	NUM
admet-2043	1617	4	(	(	PUNCT
admet-2043	1617	5	2019	2019	NUM
admet-2043	1617	6	)	)	PUNCT
admet-2043	1617	7	153	153	NUM
admet-2043	1617	8	.	.	PUNCT
admet-2043	1618	1	https://doi.org/10.1007/s11095-0192692-6	https://doi.org/10.1007/s11095-0192692-6	PROPN
admet-2043	1618	2	.	.	PUNCT
admet-2043	1619	1	[	[	X
admet-2043	1619	2	222	222	NUM
admet-2043	1619	3	]	]	PUNCT
admet-2043	1619	4	l.	l.	PROPN
admet-2043	1619	5	bregoli	bregoli	PROPN
admet-2043	1619	6	,	,	PUNCT
admet-2043	1619	7	d.	d.	PROPN
admet-2043	1619	8	movia	movia	PROPN
admet-2043	1619	9	,	,	PUNCT
admet-2043	1619	10	j.d	j.d	PROPN
admet-2043	1619	11	.	.	PROPN
admet-2043	1619	12	gavigan	gavigan	PROPN
admet-2043	1619	13	-	-	PUNCT
admet-2043	1619	14	imedio	imedio	NOUN
admet-2043	1619	15	,	,	PUNCT
admet-2043	1619	16	j.	j.	PROPN
admet-2043	1619	17	lysaght	lysaght	PROPN
admet-2043	1619	18	,	,	PUNCT
admet-2043	1619	19	j.	j.	PROPN
admet-2043	1619	20	reynolds	reynolds	PROPN
admet-2043	1619	21	,	,	PUNCT
admet-2043	1619	22	a.	a.	PROPN
admet-2043	1619	23	prina	prina	PROPN
admet-2043	1619	24	-	-	PUNCT
admet-2043	1619	25	mello	mello	PROPN
admet-2043	1619	26	.	.	PUNCT
admet-2043	1619	27	nanomedicine	nanomedicine	PROPN
admet-2043	1619	28	applied	apply	VERB
admet-2043	1619	29	to	to	ADP
admet-2043	1619	30	translational	translational	ADJ
admet-2043	1619	31	oncology	oncology	NOUN
admet-2043	1619	32	:	:	PUNCT
admet-2043	1619	33	a	a	DET
admet-2043	1619	34	future	future	ADJ
admet-2043	1619	35	perspective	perspective	NOUN
admet-2043	1619	36	on	on	ADP
admet-2043	1619	37	cancer	cancer	NOUN
admet-2043	1619	38	treatment	treatment	NOUN
admet-2043	1619	39	.	.	PUNCT
admet-2043	1620	1	nanomedicine	nanomedicine	PROPN
admet-2043	1620	2	:	:	PUNCT
admet-2043	1620	3	nanotechnology	nanotechnology	NOUN
admet-2043	1620	4	,	,	PUNCT
admet-2043	1620	5	biology	biology	NOUN
admet-2043	1620	6	,	,	PUNCT
admet-2043	1620	7	and	and	CCONJ
admet-2043	1620	8	medicine	medicine	NOUN
admet-2043	1620	9	12	12	NUM
admet-2043	1620	10	(	(	PUNCT
admet-2043	1620	11	2016	2016	NUM
admet-2043	1620	12	)	)	PUNCT
admet-2043	1620	13	81	81	NUM
admet-2043	1620	14	-	-	SYM
admet-2043	1620	15	103	103	NUM
admet-2043	1620	16	.	.	PUNCT
admet-2043	1621	1	https://doi.org/10.1016/j.nano.2015.08.006	https://doi.org/10.1016/j.nano.2015.08.006	NOUN
admet-2043	1621	2	.	.	PUNCT
admet-2043	1622	1	[	[	X
admet-2043	1622	2	223	223	NUM
admet-2043	1622	3	]	]	X
admet-2043	1622	4	r.g	r.g	PROPN
admet-2043	1622	5	.	.	PROPN
admet-2043	1622	6	lee	lee	PROPN
admet-2043	1622	7	,	,	PUNCT
admet-2043	1622	8	j.	j.	PROPN
admet-2043	1622	9	petts	petts	PROPN
admet-2043	1622	10	,	,	PUNCT
admet-2043	1622	11	adaptive	adaptive	ADJ
admet-2043	1622	12	governance	governance	NOUN
admet-2043	1622	13	for	for	ADP
admet-2043	1622	14	responsible	responsible	ADJ
admet-2043	1622	15	innovation	innovation	NOUN
admet-2043	1622	16	,	,	PUNCT
admet-2043	1622	17	in	in	ADP
admet-2043	1622	18	responsible	responsible	ADJ
admet-2043	1622	19	innovation	innovation	NOUN
admet-2043	1622	20	:	:	PUNCT
admet-2043	1622	21	managing	manage	VERB
admet-2043	1622	22	the	the	DET
admet-2043	1622	23	responsible	responsible	ADJ
admet-2043	1622	24	emergence	emergence	NOUN
admet-2043	1622	25	of	of	ADP
admet-2043	1622	26	science	science	NOUN
admet-2043	1622	27	and	and	CCONJ
admet-2043	1622	28	innovation	innovation	NOUN
admet-2043	1622	29	in	in	ADP
admet-2043	1622	30	society	society	NOUN
admet-2043	1622	31	,	,	PUNCT
admet-2043	1622	32	john	john	PROPN
admet-2043	1622	33	wiley	wiley	PROPN
admet-2043	1622	34	&	&	CCONJ
admet-2043	1622	35	sons	son	NOUN
admet-2043	1622	36	,	,	PUNCT
admet-2043	1622	37	new	new	PROPN
admet-2043	1622	38	jersey	jersey	PROPN
admet-2043	1622	39	,	,	PUNCT
admet-2043	1622	40	united	united	PROPN
admet-2043	1622	41	states	states	PROPN
admet-2043	1622	42	,	,	PUNCT
admet-2043	1622	43	2013	2013	NUM
admet-2043	1622	44	,	,	PUNCT
admet-2043	1622	45	p.	p.	NOUN
admet-2043	1622	46	143	143	NUM
admet-2043	1622	47	-	-	SYM
admet-2043	1622	48	164	164	NUM
admet-2043	1622	49	.	.	PUNCT
admet-2043	1623	1	https://doi.org/10.1002/9781118551424.ch8	https://doi.org/10.1002/9781118551424.ch8	NOUN
admet-2043	1623	2	.	.	PUNCT
admet-2043	1624	1	©	©	PROPN
admet-2043	1624	2	2023	2023	NUM
admet-2043	1624	3	by	by	ADP
admet-2043	1624	4	the	the	DET
admet-2043	1624	5	authors	author	NOUN
admet-2043	1624	6	;	;	PUNCT
admet-2043	1624	7	licensee	licensee	PROPN
admet-2043	1624	8	iapc	iapc	PROPN
admet-2043	1624	9	,	,	PUNCT
admet-2043	1624	10	zagreb	zagreb	PROPN
admet-2043	1624	11	,	,	PUNCT
admet-2043	1624	12	croatia	croatia	PROPN
admet-2043	1624	13	.	.	PUNCT
admet-2043	1625	1	this	this	DET
admet-2043	1625	2	article	article	NOUN
admet-2043	1625	3	is	be	AUX
admet-2043	1625	4	an	an	DET
admet-2043	1625	5	open	open	ADJ
admet-2043	1625	6	-	-	PUNCT
admet-2043	1625	7	access	access	NOUN
admet-2043	1625	8	article	article	NOUN
admet-2043	1625	9	distributed	distribute	VERB
admet-2043	1625	10	under	under	ADP
admet-2043	1625	11	the	the	DET
admet-2043	1625	12	terms	term	NOUN
admet-2043	1625	13	and	and	CCONJ
admet-2043	1625	14	conditions	condition	NOUN
admet-2043	1625	15	of	of	ADP
admet-2043	1625	16	the	the	DET
admet-2043	1625	17	creative	creative	ADJ
admet-2043	1625	18	commons	common	NOUN
admet-2043	1625	19	attribution	attribution	NOUN
admet-2043	1625	20	license	license	NOUN
admet-2043	1625	21	(	(	PUNCT
admet-2043	1625	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2043	1625	23	)	)	PUNCT
admet-2043	1625	24	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2043	1625	25	https://doi.org/10.2217/nnm-2016-0133	https://doi.org/10.2217/nnm-2016-0133	NOUN
admet-2043	1626	1	https://doi.org/10.1016/j.cclet.2022.05.032	https://doi.org/10.1016/j.cclet.2022.05.032	DET
admet-2043	1626	2	https://doi.org/10.3390/pharmaceutics14050987	https://doi.org/10.3390/pharmaceutics14050987	NOUN
admet-2043	1626	3	https://doi.org/10.1016/j.tibtech.2019.12.021	https://doi.org/10.1016/j.tibtech.2019.12.021	VERB
admet-2043	1626	4	https://doi.org/10.1016/b978-0-12-809717-5.00001-4	https://doi.org/10.1016/b978-0-12-809717-5.00001-4	PROPN
admet-2043	1626	5	https://doi.org/10.1016/b978-0-12-809717-5.00001-4	https://doi.org/10.1016/b978-0-12-809717-5.00001-4	PROPN
admet-2043	1626	6	https://doi.org/10.1002/adma.201506133	https://doi.org/10.1002/adma.201506133	ADV
admet-2043	1626	7	https://doi.org/10.1016/j.drudis.2018.01.047	https://doi.org/10.1016/j.drudis.2018.01.047	NUM
admet-2043	1626	8	https://doi.org/10.1016/j.ijpe.2007.02.050	https://doi.org/10.1016/j.ijpe.2007.02.050	VERB
admet-2043	1626	9	https://doi.org/10.1039/c7cs00363c	https://doi.org/10.1039/c7cs00363c	PROPN
admet-2043	1626	10	https://doi.org/10.1016/j.jpba.2022.114911	https://doi.org/10.1016/j.jpba.2022.114911	PROPN
admet-2043	1626	11	https://doi.org/10.1002/adma.201802896	https://doi.org/10.1002/adma.201802896	NOUN
admet-2043	1626	12	https://doi.org/10.1007/s11095-019-2692-6	https://doi.org/10.1007/s11095-019-2692-6	X
admet-2043	1626	13	https://doi.org/10.1007/s11095-019-2692-6	https://doi.org/10.1007/s11095-019-2692-6	NOUN
admet-2043	1626	14	https://doi.org/10.1016/j.nano.2015.08.006	https://doi.org/10.1016/j.nano.2015.08.006	PROPN
admet-2043	1626	15	https://doi.org/10.1002/9781118551424.ch8	https://doi.org/10.1002/9781118551424.ch8	PROPN
admet-2043	1626	16	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN