id sid tid token lemma pos admet-2089 1 1 enhancing enhance VERB admet-2089 1 2 encapsulation encapsulation NOUN admet-2089 1 3 of of ADP admet-2089 1 4 filarial filarial ADJ admet-2089 1 5 antigen antigen NOUN admet-2089 1 6 brugia brugia NOUN admet-2089 1 7 malayi malayi VERB admet-2089 1 8 thioredoxin thioredoxin PROPN admet-2089 1 9 in in ADP admet-2089 1 10 nano nano NOUN admet-2089 1 11 - - NOUN admet-2089 1 12 liposomes liposome NOUN admet-2089 1 13 : : PUNCT admet-2089 1 14 the the DET admet-2089 1 15 role role NOUN admet-2089 1 16 of of ADP admet-2089 1 17 lecithin lecithin NOUN admet-2089 1 18 composition composition NOUN admet-2089 1 19 doi doi NOUN admet-2089 1 20 : : PUNCT admet-2089 1 21 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 1 22 379 379 NUM admet-2089 1 23 admet admet PROPN admet-2089 1 24 & & CCONJ admet-2089 1 25 dmpk dmpk PROPN admet-2089 1 26 12(2 12(2 NUM admet-2089 1 27 ) ) PUNCT admet-2089 1 28 ( ( PUNCT admet-2089 1 29 2024 2024 NUM admet-2089 1 30 ) ) PUNCT admet-2089 1 31 379 379 NUM admet-2089 1 32 - - SYM admet-2089 1 33 389 389 NUM admet-2089 1 34 ; ; PUNCT admet-2089 1 35 doi doi NOUN admet-2089 1 36 : : PUNCT admet-2089 1 37 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 1 38 open open ADJ admet-2089 1 39 access access NOUN admet-2089 1 40 : : PUNCT admet-2089 1 41 issn issn PROPN admet-2089 1 42 : : PUNCT admet-2089 1 43 1848 1848 NUM admet-2089 1 44 - - SYM admet-2089 1 45 7718 7718 NUM admet-2089 1 46 http://www.pub.iapchem.org/ojs/index.php/admet/index http://www.pub.iapchem.org/ojs/index.php/admet/index NOUN admet-2089 1 47 original original ADJ admet-2089 1 48 scientific scientific ADJ admet-2089 1 49 paper paper NOUN admet-2089 1 50 enhancing enhance VERB admet-2089 1 51 encapsulation encapsulation NOUN admet-2089 1 52 of of ADP admet-2089 1 53 filarial filarial ADJ admet-2089 1 54 antigen antigen NOUN admet-2089 1 55 brugia brugia NOUN admet-2089 1 56 malayi malayi VERB admet-2089 1 57 thioredoxin thioredoxin PROPN admet-2089 1 58 in in ADP admet-2089 1 59 nano nano NOUN admet-2089 1 60 - - NOUN admet-2089 1 61 liposomes liposome NOUN admet-2089 1 62 : : PUNCT admet-2089 1 63 the the DET admet-2089 1 64 role role NOUN admet-2089 1 65 of of ADP admet-2089 1 66 lecithin lecithin NOUN admet-2089 1 67 composition composition NOUN admet-2089 1 68 malathi malathi NOUN admet-2089 1 69 balasubramaniyan1,2 balasubramaniyan1,2 PROPN admet-2089 1 70 , , PUNCT admet-2089 1 71 * * PROPN admet-2089 1 72 , , PUNCT admet-2089 1 73 vimalraj vimalraj PROPN admet-2089 1 74 vinayagam3 vinayagam3 PROPN admet-2089 1 75 , , PUNCT admet-2089 1 76 moni moni PROPN admet-2089 1 77 philip philip PROPN admet-2089 1 78 jacob jacob PROPN admet-2089 1 79 kizhakedathil4 kizhakedathil4 VERB admet-2089 1 80 and and CCONJ admet-2089 1 81 kaliraj kaliraj PROPN admet-2089 1 82 perumal5 perumal5 PROPN admet-2089 1 83 , , PUNCT admet-2089 1 84 * * PUNCT admet-2089 1 85 * * PROPN admet-2089 1 86 1department 1department NUM admet-2089 1 87 centre centre NOUN admet-2089 1 88 for for ADP admet-2089 1 89 nanoscience nanoscience NOUN admet-2089 1 90 and and CCONJ admet-2089 1 91 technology technology NOUN admet-2089 1 92 , , PUNCT admet-2089 1 93 anna anna PROPN admet-2089 1 94 university university PROPN admet-2089 1 95 , , PUNCT admet-2089 1 96 guindy guindy NOUN admet-2089 1 97 , , PUNCT admet-2089 1 98 chennai chennai NOUN admet-2089 1 99 600025 600025 NUM admet-2089 1 100 , , PUNCT admet-2089 1 101 tamilnadu tamilnadu NOUN admet-2089 1 102 , , PUNCT admet-2089 1 103 india india PROPN admet-2089 1 104 2department 2department PROPN admet-2089 1 105 of of ADP admet-2089 1 106 biotechnology biotechnology NOUN admet-2089 1 107 , , PUNCT admet-2089 1 108 vignan vignan NOUN admet-2089 1 109 's 's PART admet-2089 1 110 foundation foundation NOUN admet-2089 1 111 for for ADP admet-2089 1 112 science science NOUN admet-2089 1 113 , , PUNCT admet-2089 1 114 technology technology NOUN admet-2089 1 115 & & CCONJ admet-2089 1 116 research research PROPN admet-2089 1 117 university university PROPN admet-2089 1 118 , , PUNCT admet-2089 1 119 vadlamudi vadlamudi NOUN admet-2089 1 120 522213 522213 NUM admet-2089 1 121 , , PUNCT admet-2089 1 122 andhra andhra PROPN admet-2089 1 123 pradesh pradesh PROPN admet-2089 1 124 , , PUNCT admet-2089 1 125 india india PROPN admet-2089 1 126 3department 3department PROPN admet-2089 1 127 of of ADP admet-2089 1 128 chemistry chemistry NOUN admet-2089 1 129 , , PUNCT admet-2089 1 130 bannari bannari PROPN admet-2089 1 131 amman amman PROPN admet-2089 1 132 institute institute PROPN admet-2089 1 133 of of ADP admet-2089 1 134 technology technology PROPN admet-2089 1 135 , , PUNCT admet-2089 1 136 sathyamangalam sathyamangalam PROPN admet-2089 1 137 , , PUNCT admet-2089 1 138 638401 638401 NUM admet-2089 1 139 , , PUNCT admet-2089 1 140 tamilnadu tamilnadu NOUN admet-2089 1 141 , , PUNCT admet-2089 1 142 india india PROPN admet-2089 1 143 4department 4department NUM admet-2089 1 144 of of ADP admet-2089 1 145 biotechnology biotechnology NOUN admet-2089 1 146 , , PUNCT admet-2089 1 147 bannari bannari PROPN admet-2089 1 148 amman amman PROPN admet-2089 1 149 institute institute PROPN admet-2089 1 150 of of ADP admet-2089 1 151 technology technology PROPN admet-2089 1 152 , , PUNCT admet-2089 1 153 sathyamangalam sathyamangalam PROPN admet-2089 1 154 , , PUNCT admet-2089 1 155 638401 638401 NUM admet-2089 1 156 , , PUNCT admet-2089 1 157 tamilnadu tamilnadu NOUN admet-2089 1 158 , , PUNCT admet-2089 1 159 india india PROPN admet-2089 1 160 5centre 5centre PROPN admet-2089 1 161 for for ADP admet-2089 1 162 biotechnology biotechnology NOUN admet-2089 1 163 , , PUNCT admet-2089 1 164 anna anna PROPN admet-2089 1 165 university university PROPN admet-2089 1 166 , , PUNCT admet-2089 1 167 guindy guindy NOUN admet-2089 1 168 , , PUNCT admet-2089 1 169 chennai chennai NOUN admet-2089 1 170 600025 600025 NUM admet-2089 1 171 , , PUNCT admet-2089 1 172 tamilnadu tamilnadu NOUN admet-2089 1 173 , , PUNCT admet-2089 1 174 india india PROPN admet-2089 1 175 * * PUNCT admet-2089 1 176 corresponding correspond VERB admet-2089 1 177 authors author NOUN admet-2089 1 178 : : PUNCT admet-2089 1 179 e e X admet-2089 1 180 - - NOUN admet-2089 1 181 mail mail NOUN admet-2089 1 182 : : PUNCT admet-2089 1 183 * * PUNCT admet-2089 1 184 malabala7@gmail.com malabala7@gmail.com X admet-2089 1 185 ; ; PUNCT admet-2089 1 186 * * PUNCT admet-2089 1 187 * * PUNCT admet-2089 1 188 pkaliraj@gmail.com pkaliraj@gmail.com PUNCT admet-2089 1 189 received receive VERB admet-2089 1 190 : : PUNCT admet-2089 1 191 september september PROPN admet-2089 1 192 19 19 NUM admet-2089 1 193 , , PUNCT admet-2089 1 194 2023 2023 NUM admet-2089 1 195 ; ; PUNCT admet-2089 1 196 revised revise VERB admet-2089 1 197 : : PUNCT admet-2089 1 198 november november PROPN admet-2089 1 199 13 13 NUM admet-2089 1 200 , , PUNCT admet-2089 1 201 2023 2023 NUM admet-2089 1 202 ; ; PUNCT admet-2089 1 203 published publish VERB admet-2089 1 204 : : PUNCT admet-2089 1 205 november november PROPN admet-2089 1 206 30 30 NUM admet-2089 1 207 , , PUNCT admet-2089 1 208 2023 2023 NUM admet-2089 1 209 abstract abstract ADJ admet-2089 1 210 background background NOUN admet-2089 1 211 and and CCONJ admet-2089 1 212 purpose purpose NOUN admet-2089 1 213 : : PUNCT admet-2089 1 214 lymphatic lymphatic ADJ admet-2089 1 215 filariasis filariasis NOUN admet-2089 1 216 is be AUX admet-2089 1 217 a a DET admet-2089 1 218 debilitating debilitate VERB admet-2089 1 219 infectious infectious ADJ admet-2089 1 220 disease disease NOUN admet-2089 1 221 prevalent prevalent ADJ admet-2089 1 222 in in ADP admet-2089 1 223 endemic endemic ADJ admet-2089 1 224 areas area NOUN admet-2089 1 225 , , PUNCT admet-2089 1 226 necessitating necessitate VERB admet-2089 1 227 the the DET admet-2089 1 228 development development NOUN admet-2089 1 229 of of ADP admet-2089 1 230 an an DET admet-2089 1 231 effective effective ADJ admet-2089 1 232 vaccine vaccine NOUN admet-2089 1 233 for for ADP admet-2089 1 234 eradication eradication NOUN admet-2089 1 235 . . PUNCT admet-2089 2 1 although although SCONJ admet-2089 2 2 recombinant recombinant ADJ admet-2089 2 3 vaccine vaccine NOUN admet-2089 2 4 candidates candidate NOUN admet-2089 2 5 have have AUX admet-2089 2 6 been be AUX admet-2089 2 7 deemed deem VERB admet-2089 2 8 safe safe ADJ admet-2089 2 9 , , PUNCT admet-2089 2 10 they they PRON admet-2089 2 11 often often ADV admet-2089 2 12 fail fail VERB admet-2089 2 13 to to PART admet-2089 2 14 provide provide VERB admet-2089 2 15 sufficient sufficient ADJ admet-2089 2 16 protection protection NOUN admet-2089 2 17 , , PUNCT admet-2089 2 18 which which PRON admet-2089 2 19 can can AUX admet-2089 2 20 be be AUX admet-2089 2 21 overcome overcome VERB admet-2089 2 22 by by ADP admet-2089 2 23 encapsulating encapsulate VERB admet-2089 2 24 them they PRON admet-2089 2 25 in in ADP admet-2089 2 26 nano nano NOUN admet-2089 2 27 - - PUNCT admet-2089 2 28 liposomes liposome NOUN admet-2089 2 29 . . PUNCT admet-2089 3 1 in in ADP admet-2089 3 2 this this DET admet-2089 3 3 study study NOUN admet-2089 3 4 , , PUNCT admet-2089 3 5 we we PRON admet-2089 3 6 have have AUX admet-2089 3 7 optimised optimise VERB admet-2089 3 8 the the DET admet-2089 3 9 liposomal liposomal ADJ admet-2089 3 10 composition composition NOUN admet-2089 3 11 for for ADP admet-2089 3 12 enhanced enhanced ADJ admet-2089 3 13 stability stability NOUN admet-2089 3 14 and and CCONJ admet-2089 3 15 encapsulation encapsulation NOUN admet-2089 3 16 of of ADP admet-2089 3 17 filarial filarial ADJ admet-2089 3 18 antigen antigen NOUN admet-2089 3 19 brugia brugia NOUN admet-2089 3 20 malayi malayi VERB admet-2089 3 21 thioredoxin thioredoxin PROPN admet-2089 3 22 ( ( PUNCT admet-2089 3 23 bm bm PROPN admet-2089 3 24 - - NOUN admet-2089 3 25 trx trx NOUN admet-2089 3 26 ) ) PUNCT admet-2089 3 27 . . PUNCT admet-2089 4 1 experimental experimental ADJ admet-2089 4 2 approach approach NOUN admet-2089 4 3 : : PUNCT admet-2089 4 4 nano nano NOUN admet-2089 4 5 - - PUNCT admet-2089 4 6 liposomes liposome NOUN admet-2089 4 7 were be AUX admet-2089 4 8 prepared prepare VERB admet-2089 4 9 using use VERB admet-2089 4 10 egg egg NOUN admet-2089 4 11 phosphatidylcholine phosphatidylcholine NOUN admet-2089 4 12 ( ( PUNCT admet-2089 4 13 epc epc PROPN admet-2089 4 14 ) ) PUNCT admet-2089 4 15 and and CCONJ admet-2089 4 16 cholesterol cholesterol NOUN admet-2089 4 17 via via ADP admet-2089 4 18 thin thin ADJ admet-2089 4 19 - - PUNCT admet-2089 4 20 film film NOUN admet-2089 4 21 hydration hydration NOUN admet-2089 4 22 , , PUNCT admet-2089 4 23 followed follow VERB admet-2089 4 24 by by ADP admet-2089 4 25 sonication sonication NOUN admet-2089 4 26 and and CCONJ admet-2089 4 27 characterizing characterizing NOUN admet-2089 4 28 . . PUNCT admet-2089 5 1 encapsulation encapsulation NOUN admet-2089 5 2 efficiency efficiency NOUN admet-2089 5 3 was be AUX admet-2089 5 4 optimised optimise VERB admet-2089 5 5 using use VERB admet-2089 5 6 different different ADJ admet-2089 5 7 weight weight NOUN admet-2089 5 8 ratios ratio NOUN admet-2089 5 9 of of ADP admet-2089 5 10 epc epc PROPN admet-2089 5 11 to to ADP admet-2089 5 12 cholesterol cholesterol NOUN admet-2089 5 13 ( ( PUNCT admet-2089 5 14 8:2 8:2 NUM admet-2089 5 15 , , PUNCT admet-2089 5 16 7:3 7:3 NUM admet-2089 5 17 , , PUNCT admet-2089 5 18 and and CCONJ admet-2089 5 19 6:4 6:4 NUM admet-2089 5 20 ) ) PUNCT admet-2089 5 21 and and CCONJ admet-2089 5 22 total total ADJ admet-2089 5 23 lipid lipid NOUN admet-2089 5 24 ( ( PUNCT admet-2089 5 25 epc+cholesterol epc+cholesterol NOUN admet-2089 5 26 ) ) PUNCT admet-2089 5 27 concentration concentration NOUN admet-2089 5 28 to to AUX admet-2089 5 29 antigen antigen VERB admet-2089 5 30 bm bm PROPN admet-2089 5 31 - - PROPN admet-2089 5 32 trx trx PROPN admet-2089 5 33 ( ( PUNCT admet-2089 5 34 10:1 10:1 NUM admet-2089 5 35 , , PUNCT admet-2089 5 36 10:2 10:2 NUM admet-2089 5 37 , , PUNCT admet-2089 5 38 and and CCONJ admet-2089 5 39 10:3 10:3 NUM admet-2089 5 40 ) ) PUNCT admet-2089 5 41 followed follow VERB admet-2089 5 42 by by ADP admet-2089 5 43 release release NOUN admet-2089 5 44 kinetics kinetic NOUN admet-2089 5 45 study study NOUN admet-2089 5 46 . . PUNCT admet-2089 6 1 key key ADJ admet-2089 6 2 results result NOUN admet-2089 6 3 : : PUNCT admet-2089 6 4 optimised optimise VERB admet-2089 6 5 parameters parameter NOUN admet-2089 6 6 yielded yield VERB admet-2089 6 7 spherical spherical ADJ admet-2089 6 8 liposomes liposome NOUN admet-2089 6 9 measuring measure VERB admet-2089 6 10 209 209 NUM admet-2089 6 11 nm nm NOUN admet-2089 6 12 in in ADP admet-2089 6 13 diameter diameter NOUN admet-2089 6 14 with with ADP admet-2089 6 15 narrow narrow ADJ admet-2089 6 16 polydispersity polydispersity NOUN admet-2089 6 17 . . PUNCT admet-2089 7 1 our our PRON admet-2089 7 2 findings finding NOUN admet-2089 7 3 demonstrated demonstrate VERB admet-2089 7 4 the the DET admet-2089 7 5 highest high ADJ admet-2089 7 6 encapsulation encapsulation NOUN admet-2089 7 7 efficiency efficiency NOUN admet-2089 7 8 of of ADP admet-2089 7 9 70.685 70.685 NUM admet-2089 7 10 % % NOUN admet-2089 7 11 and and CCONJ admet-2089 7 12 stability stability NOUN admet-2089 7 13 of of ADP admet-2089 7 14 10 10 NUM admet-2089 7 15 hours hour NOUN admet-2089 7 16 for for ADP admet-2089 7 17 an an DET admet-2089 7 18 epc epc PROPN admet-2089 7 19 to to AUX admet-2089 7 20 cholesterol cholesterol VERB admet-2089 7 21 weight weight NOUN admet-2089 7 22 ratio ratio NOUN admet-2089 7 23 of of ADP admet-2089 7 24 7:3 7:3 NUM admet-2089 7 25 . . PUNCT admet-2089 8 1 the the DET admet-2089 8 2 in in ADP admet-2089 8 3 silico silico NOUN admet-2089 8 4 study study NOUN admet-2089 8 5 proved prove VERB admet-2089 8 6 the the DET admet-2089 8 7 antigenic antigenic ADJ admet-2089 8 8 nature nature NOUN admet-2089 8 9 of of ADP admet-2089 8 10 trx trx PROPN admet-2089 8 11 . . PUNCT admet-2089 9 1 conclusion conclusion NOUN admet-2089 9 2 : : PUNCT admet-2089 9 3 the the DET admet-2089 9 4 liposomal liposomal PROPN admet-2089 9 5 formulations formulation NOUN admet-2089 9 6 loaded load VERB admet-2089 9 7 with with ADP admet-2089 9 8 trx trx PROPN admet-2089 9 9 , , PUNCT admet-2089 9 10 as as SCONJ admet-2089 9 11 optimized optimize VERB admet-2089 9 12 in in ADP admet-2089 9 13 this this DET admet-2089 9 14 study study NOUN admet-2089 9 15 , , PUNCT admet-2089 9 16 hold hold VERB admet-2089 9 17 promise promise NOUN admet-2089 9 18 for for ADP admet-2089 9 19 improving improve VERB admet-2089 9 20 antigen antigen ADJ admet-2089 9 21 efficiency efficiency NOUN admet-2089 9 22 by by ADP admet-2089 9 23 enhancing enhance VERB admet-2089 9 24 stability stability NOUN admet-2089 9 25 , , PUNCT admet-2089 9 26 bioavailability bioavailability NOUN admet-2089 9 27 , , PUNCT admet-2089 9 28 and and CCONJ admet-2089 9 29 prophylactic prophylactic ADJ admet-2089 9 30 effects effect NOUN admet-2089 9 31 by by ADP admet-2089 9 32 acting act VERB admet-2089 9 33 as as ADP admet-2089 9 34 immune immune ADJ admet-2089 9 35 potentiators potentiator NOUN admet-2089 9 36 . . PUNCT admet-2089 10 1 © © NOUN admet-2089 10 2 2023 2023 NUM admet-2089 10 3 by by ADP admet-2089 10 4 the the DET admet-2089 10 5 authors author NOUN admet-2089 10 6 . . PUNCT admet-2089 11 1 this this DET admet-2089 11 2 article article NOUN admet-2089 11 3 is be AUX admet-2089 11 4 an an DET admet-2089 11 5 open open ADJ admet-2089 11 6 - - PUNCT admet-2089 11 7 access access NOUN admet-2089 11 8 article article NOUN admet-2089 11 9 distributed distribute VERB admet-2089 11 10 under under ADP admet-2089 11 11 the the DET admet-2089 11 12 terms term NOUN admet-2089 11 13 and and CCONJ admet-2089 11 14 conditions condition NOUN admet-2089 11 15 of of ADP admet-2089 11 16 the the DET admet-2089 11 17 creative creative ADJ admet-2089 11 18 commons common NOUN admet-2089 11 19 attribution attribution NOUN admet-2089 11 20 license license NOUN admet-2089 11 21 ( ( PUNCT admet-2089 11 22 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ PROPN admet-2089 11 23 ) ) PUNCT admet-2089 11 24 . . PUNCT admet-2089 12 1 keywords keyword NOUN admet-2089 12 2 liposome liposome VERB admet-2089 12 3 ; ; PUNCT admet-2089 12 4 lymphatic lymphatic ADJ admet-2089 12 5 filariasis filariasis NOUN admet-2089 12 6 ; ; PUNCT admet-2089 12 7 thioredoxin thioredoxin NOUN admet-2089 12 8 ; ; PUNCT admet-2089 12 9 egg egg NOUN admet-2089 12 10 phosphatidylcholine phosphatidylcholine NOUN admet-2089 12 11 ; ; PUNCT admet-2089 12 12 cholesterol cholesterol NOUN admet-2089 12 13 introduction introduction NOUN admet-2089 12 14 lymphatic lymphatic ADJ admet-2089 12 15 filariasis filariasis NOUN admet-2089 12 16 ( ( PUNCT admet-2089 12 17 lf lf NOUN admet-2089 12 18 ) ) PUNCT admet-2089 12 19 is be AUX admet-2089 12 20 a a DET admet-2089 12 21 vector vector NOUN admet-2089 12 22 - - PUNCT admet-2089 12 23 borne bear VERB admet-2089 12 24 morbid morbid ADJ admet-2089 12 25 infectious infectious ADJ admet-2089 12 26 disease disease NOUN admet-2089 12 27 caused cause VERB admet-2089 12 28 by by ADP admet-2089 12 29 filarial filarial ADJ admet-2089 12 30 worms worm NOUN admet-2089 12 31 wuchereria wuchereria PROPN admet-2089 12 32 bancrofti bancrofti NOUN admet-2089 12 33 ( ( PUNCT admet-2089 12 34 wb wb NOUN admet-2089 12 35 ) ) PUNCT admet-2089 12 36 and and CCONJ admet-2089 12 37 brugia brugia ADJ admet-2089 12 38 malayi malayi VERB admet-2089 12 39 ( ( PUNCT admet-2089 12 40 bm bm PROPN admet-2089 12 41 ) ) PUNCT admet-2089 12 42 . . PUNCT admet-2089 13 1 lf lf NOUN admet-2089 13 2 creates create VERB admet-2089 13 3 profound profound ADJ admet-2089 13 4 disfiguring disfiguring ADJ admet-2089 13 5 and and CCONJ admet-2089 13 6 socio socio NOUN admet-2089 13 7 - - PUNCT admet-2089 13 8 economic economic ADJ admet-2089 13 9 problems problem NOUN admet-2089 13 10 along along ADP admet-2089 13 11 with with ADP admet-2089 13 12 health health NOUN admet-2089 13 13 complications complication NOUN admet-2089 13 14 in in ADP admet-2089 13 15 developing develop VERB admet-2089 13 16 countries country NOUN admet-2089 13 17 [ [ X admet-2089 13 18 1 1 NUM admet-2089 13 19 ] ] PUNCT admet-2089 13 20 . . PUNCT admet-2089 14 1 these these DET admet-2089 14 2 nematode nematode NOUN admet-2089 14 3 infections infection NOUN admet-2089 14 4 are be AUX admet-2089 14 5 the the DET admet-2089 14 6 world world NOUN admet-2089 14 7 's 's PART admet-2089 14 8 second second ADJ admet-2089 14 9 leading lead VERB admet-2089 14 10 cause cause NOUN admet-2089 14 11 of of ADP admet-2089 14 12 permanent permanent ADJ admet-2089 14 13 and and CCONJ admet-2089 14 14 long long ADJ admet-2089 14 15 - - PUNCT admet-2089 14 16 term term NOUN admet-2089 14 17 disability disability NOUN admet-2089 14 18 [ [ X admet-2089 14 19 2 2 NUM admet-2089 14 20 ] ] PUNCT admet-2089 14 21 . . PUNCT admet-2089 15 1 tragically tragically ADV admet-2089 15 2 , , PUNCT admet-2089 15 3 120 120 NUM admet-2089 15 4 million million NUM admet-2089 15 5 people people NOUN admet-2089 15 6 are be AUX admet-2089 15 7 affected affect VERB admet-2089 15 8 by by ADP admet-2089 15 9 lf lf PROPN admet-2089 15 10 , , PUNCT admet-2089 15 11 and and CCONJ admet-2089 15 12 still still ADV admet-2089 15 13 , , PUNCT admet-2089 15 14 1.39 1.39 NUM admet-2089 15 15 billion billion NUM admet-2089 15 16 are be AUX admet-2089 15 17 prone prone ADJ admet-2089 15 18 to to ADP admet-2089 15 19 infection infection NOUN admet-2089 15 20 risk risk NOUN admet-2089 15 21 [ [ X admet-2089 15 22 3 3 NUM admet-2089 15 23 ] ] PUNCT admet-2089 15 24 . . PUNCT admet-2089 16 1 the the DET admet-2089 16 2 current current ADJ admet-2089 16 3 prevention prevention NOUN admet-2089 16 4 and and CCONJ admet-2089 16 5 prophylaxis prophylaxis NOUN admet-2089 16 6 involve involve VERB admet-2089 16 7 diagnosis diagnosis NOUN admet-2089 16 8 , , PUNCT admet-2089 16 9 inhibition inhibition NOUN admet-2089 16 10 of of ADP admet-2089 16 11 transmission transmission NOUN admet-2089 16 12 , , PUNCT admet-2089 16 13 morbidity morbidity NOUN admet-2089 16 14 control control NOUN admet-2089 16 15 and and CCONJ admet-2089 16 16 disability disability NOUN admet-2089 16 17 avoidance avoidance NOUN admet-2089 16 18 . . PUNCT admet-2089 17 1 interruption interruption NOUN admet-2089 17 2 of of ADP admet-2089 17 3 transmission transmission NOUN admet-2089 17 4 for for ADP admet-2089 17 5 the the DET admet-2089 17 6 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 ADJ admet-2089 17 7 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 17 8 http://www.pub.iapchem.org/ojs/index.php/admet/index http://www.pub.iapchem.org/ojs/index.php/admet/index NOUN admet-2089 17 9 mailto:malabala7@gmail.com mailto:malabala7@gmail.com X admet-2089 17 10 mailto:pkaliraj@gmail.com mailto:pkaliraj@gmail.com X admet-2089 18 1 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ PROPN admet-2089 18 2 https://paperpile.com/c/plxgz5/mgzwt https://paperpile.com/c/plxgz5/mgzwt NOUN admet-2089 18 3 https://paperpile.com/c/plxgz5/sgofz https://paperpile.com/c/plxgz5/sgofz PROPN admet-2089 18 4 https://paperpile.com/c/plxgz5/6zpui https://paperpile.com/c/plxgz5/6zpui X admet-2089 19 1 m. m. PROPN admet-2089 19 2 balasubramaniyan balasubramaniyan PROPN admet-2089 19 3 et et PROPN admet-2089 19 4 al al PROPN admet-2089 19 5 . . PROPN admet-2089 19 6 admet admet PROPN admet-2089 19 7 & & CCONJ admet-2089 19 8 dmpk dmpk PROPN admet-2089 19 9 12(2 12(2 NUM admet-2089 19 10 ) ) PUNCT admet-2089 19 11 ( ( PUNCT admet-2089 19 12 2024 2024 NUM admet-2089 19 13 ) ) PUNCT admet-2089 19 14 379 379 NUM admet-2089 19 15 - - SYM admet-2089 19 16 389 389 NUM admet-2089 19 17 380 380 NUM admet-2089 19 18 population population NOUN admet-2089 19 19 at at ADP admet-2089 19 20 risk risk NOUN admet-2089 19 21 is be AUX admet-2089 19 22 achieved achieve VERB admet-2089 19 23 by by ADP admet-2089 19 24 mass mass PROPN admet-2089 19 25 drug drug PROPN admet-2089 19 26 administration administration NOUN admet-2089 19 27 of of ADP admet-2089 19 28 albendazole albendazole PROPN admet-2089 19 29 plus plus CCONJ admet-2089 19 30 either either CCONJ admet-2089 19 31 diethylcarbamazine diethylcarbamazine VERB admet-2089 19 32 or or CCONJ admet-2089 19 33 ivermectin ivermectin NOUN admet-2089 20 1 [ [ X admet-2089 20 2 4,5 4,5 NUM admet-2089 20 3 ] ] PUNCT admet-2089 20 4 . . PUNCT admet-2089 21 1 but but CCONJ admet-2089 21 2 , , PUNCT admet-2089 21 3 the the DET admet-2089 21 4 complex complex ADJ admet-2089 21 5 life life NOUN admet-2089 21 6 cycle cycle NOUN admet-2089 21 7 of of ADP admet-2089 21 8 the the DET admet-2089 21 9 filarial filarial ADJ admet-2089 21 10 worm worm NOUN admet-2089 21 11 makes make VERB admet-2089 21 12 the the DET admet-2089 21 13 pharmacological pharmacological ADJ admet-2089 21 14 efficacy efficacy NOUN admet-2089 21 15 limited limit VERB admet-2089 21 16 . . PUNCT admet-2089 22 1 also also ADV admet-2089 22 2 , , PUNCT admet-2089 22 3 there there PRON admet-2089 22 4 is be VERB admet-2089 22 5 an an DET admet-2089 22 6 evolving evolve VERB admet-2089 22 7 issue issue NOUN admet-2089 22 8 of of ADP admet-2089 22 9 drug drug NOUN admet-2089 22 10 resistance resistance NOUN admet-2089 22 11 and and CCONJ admet-2089 22 12 rapid rapid ADJ admet-2089 22 13 re re NOUN admet-2089 22 14 - - NOUN admet-2089 22 15 emergence emergence NOUN admet-2089 22 16 of of ADP admet-2089 22 17 lf lf NOUN admet-2089 22 18 in in ADP admet-2089 22 19 endemic endemic ADJ admet-2089 22 20 areas area NOUN admet-2089 22 21 where where SCONJ admet-2089 22 22 transmission transmission NOUN admet-2089 22 23 can can AUX admet-2089 22 24 not not PART admet-2089 22 25 be be AUX admet-2089 22 26 interrupted interrupt VERB admet-2089 22 27 . . PUNCT admet-2089 23 1 these these DET admet-2089 23 2 issues issue NOUN admet-2089 23 3 led lead VERB admet-2089 23 4 to to ADP admet-2089 23 5 new new ADJ admet-2089 23 6 intervention intervention NOUN admet-2089 23 7 strategies strategy NOUN admet-2089 23 8 for for ADP admet-2089 23 9 identifying identify VERB admet-2089 23 10 and and CCONJ admet-2089 23 11 successfully successfully ADV admet-2089 23 12 developing develop VERB admet-2089 23 13 several several ADJ admet-2089 23 14 recombinant recombinant ADJ admet-2089 23 15 proteins protein NOUN admet-2089 23 16 from from ADP admet-2089 23 17 filarial filarial ADJ admet-2089 23 18 worms worm NOUN admet-2089 23 19 as as ADP admet-2089 23 20 effective effective ADJ admet-2089 23 21 vaccine vaccine NOUN admet-2089 23 22 candidates candidate NOUN admet-2089 23 23 for for ADP admet-2089 23 24 prophylactics prophylactic NOUN admet-2089 23 25 . . PUNCT admet-2089 24 1 thioredoxin thioredoxin PROPN admet-2089 24 2 ( ( PUNCT admet-2089 24 3 trx trx NOUN admet-2089 24 4 ) ) PUNCT admet-2089 24 5 , , PUNCT admet-2089 24 6 exhibiting exhibit VERB admet-2089 24 7 antioxidant antioxidant ADJ admet-2089 24 8 properties property NOUN admet-2089 24 9 found find VERB admet-2089 24 10 in in ADP admet-2089 24 11 nematodes nematode NOUN admet-2089 24 12 , , PUNCT admet-2089 24 13 has have AUX admet-2089 24 14 proved prove VERB admet-2089 24 15 to to PART admet-2089 24 16 play play VERB admet-2089 24 17 a a DET admet-2089 24 18 crucial crucial ADJ admet-2089 24 19 role role NOUN admet-2089 24 20 in in ADP admet-2089 24 21 parasite parasite NOUN admet-2089 24 22 ’s ’s PART admet-2089 24 23 regulatory regulatory ADJ admet-2089 24 24 and and CCONJ admet-2089 24 25 immune immune ADJ admet-2089 24 26 - - PUNCT admet-2089 24 27 modulatory modulatory NOUN admet-2089 24 28 evasion evasion NOUN admet-2089 24 29 mechanisms mechanism NOUN admet-2089 24 30 [ [ X admet-2089 24 31 6 6 NUM admet-2089 24 32 ] ] PUNCT admet-2089 24 33 . . PUNCT admet-2089 25 1 the the DET admet-2089 25 2 recombinant recombinant ADJ admet-2089 25 3 trx trx NOUN admet-2089 25 4 from from ADP admet-2089 25 5 brugia brugia ADJ admet-2089 25 6 malayi malayi NOUN admet-2089 25 7 ( ( PUNCT admet-2089 25 8 bm bm PROPN admet-2089 25 9 - - NOUN admet-2089 25 10 trx trx NOUN admet-2089 25 11 ) ) PUNCT admet-2089 25 12 has have AUX admet-2089 25 13 provided provide VERB admet-2089 25 14 63 63 NUM admet-2089 25 15 % % NOUN admet-2089 25 16 protection protection NOUN admet-2089 25 17 in in ADP admet-2089 25 18 murine murine ADJ admet-2089 25 19 animal animal NOUN admet-2089 25 20 models model NOUN admet-2089 25 21 [ [ X admet-2089 25 22 7 7 NUM admet-2089 25 23 ] ] PUNCT admet-2089 25 24 . . PUNCT admet-2089 26 1 but but CCONJ admet-2089 26 2 , , PUNCT admet-2089 26 3 this this DET admet-2089 26 4 recombinant recombinant ADJ admet-2089 26 5 antigen antigen NOUN admet-2089 26 6 has have AUX admet-2089 26 7 failed fail VERB admet-2089 26 8 to to PART admet-2089 26 9 produce produce VERB admet-2089 26 10 a a DET admet-2089 26 11 high high ADJ admet-2089 26 12 degree degree NOUN admet-2089 26 13 of of ADP admet-2089 26 14 protection protection NOUN admet-2089 26 15 , , PUNCT admet-2089 26 16 unlike unlike ADP admet-2089 26 17 irradiated irradiate VERB admet-2089 26 18 infective infective ADJ admet-2089 26 19 third third ADJ admet-2089 26 20 - - PUNCT admet-2089 26 21 stage stage NOUN admet-2089 26 22 larvae larvae NOUN admet-2089 26 23 ( ( PUNCT admet-2089 26 24 l3 l3 X admet-2089 26 25 ) ) PUNCT admet-2089 27 1 [ [ X admet-2089 27 2 8,9 8,9 NUM admet-2089 27 3 ] ] PUNCT admet-2089 27 4 . . PUNCT admet-2089 28 1 these these DET admet-2089 28 2 issues issue NOUN admet-2089 28 3 might might AUX admet-2089 28 4 be be AUX admet-2089 28 5 mainly mainly ADV admet-2089 28 6 due due ADJ admet-2089 28 7 to to ADP admet-2089 28 8 the the DET admet-2089 28 9 degradation degradation NOUN admet-2089 28 10 of of ADP admet-2089 28 11 antigens antigen NOUN admet-2089 28 12 and and CCONJ admet-2089 28 13 , , PUNCT admet-2089 28 14 thereby thereby ADV admet-2089 28 15 , , PUNCT admet-2089 28 16 leading lead VERB admet-2089 28 17 to to ADP admet-2089 28 18 low low ADJ admet-2089 28 19 availability availability NOUN admet-2089 28 20 in in ADP admet-2089 28 21 vivo vivo NOUN admet-2089 28 22 . . PUNCT admet-2089 29 1 therefore therefore ADV admet-2089 29 2 , , PUNCT admet-2089 29 3 to to PART admet-2089 29 4 increase increase VERB admet-2089 29 5 antigen antigen ADJ admet-2089 29 6 stability stability NOUN admet-2089 29 7 and and CCONJ admet-2089 29 8 enhance enhance VERB admet-2089 29 9 sustained sustained ADJ admet-2089 29 10 release release NOUN admet-2089 29 11 , , PUNCT admet-2089 29 12 they they PRON admet-2089 29 13 can can AUX admet-2089 29 14 be be AUX admet-2089 29 15 encapsulated encapsulate VERB admet-2089 29 16 in in ADP admet-2089 29 17 carriers carrier NOUN admet-2089 29 18 such such ADJ admet-2089 29 19 as as ADP admet-2089 29 20 liposomes liposome NOUN admet-2089 29 21 [ [ X admet-2089 29 22 10,11 10,11 NOUN admet-2089 29 23 ] ] PUNCT admet-2089 29 24 . . PUNCT admet-2089 30 1 liposomes liposome NOUN admet-2089 30 2 are be AUX admet-2089 30 3 carriers carrier NOUN admet-2089 30 4 with with ADP admet-2089 30 5 sizes size NOUN admet-2089 30 6 ranging range VERB admet-2089 30 7 from from ADP admet-2089 30 8 nano nano NOUN admet-2089 30 9 to to ADP admet-2089 30 10 micron micron NOUN admet-2089 30 11 scale scale NOUN admet-2089 30 12 and and CCONJ admet-2089 30 13 are be AUX admet-2089 30 14 formed form VERB admet-2089 30 15 by by ADP admet-2089 30 16 combinations combination NOUN admet-2089 30 17 of of ADP admet-2089 30 18 various various ADJ admet-2089 30 19 phospholipids phospholipid NOUN admet-2089 30 20 and and CCONJ admet-2089 30 21 cholesterol cholesterol NOUN admet-2089 30 22 [ [ X admet-2089 30 23 12 12 NUM admet-2089 30 24 ] ] PUNCT admet-2089 30 25 . . PUNCT admet-2089 31 1 these these DET admet-2089 31 2 lipids lipid NOUN admet-2089 31 3 are be AUX admet-2089 31 4 obtained obtain VERB admet-2089 31 5 from from ADP admet-2089 31 6 natural natural ADJ admet-2089 31 7 sources source NOUN admet-2089 31 8 , , PUNCT admet-2089 31 9 such such ADJ admet-2089 31 10 as as ADP admet-2089 31 11 chicken chicken NOUN admet-2089 31 12 egg egg NOUN admet-2089 31 13 yolk yolk NOUN admet-2089 31 14 or or CCONJ admet-2089 31 15 soybeans soybean NOUN admet-2089 31 16 , , PUNCT admet-2089 31 17 and and CCONJ admet-2089 31 18 therefore therefore ADV admet-2089 31 19 are be AUX admet-2089 31 20 considered consider VERB admet-2089 31 21 safe safe ADJ admet-2089 31 22 ( ( PUNCT admet-2089 31 23 gras gras PROPN admet-2089 31 24 ) ) PUNCT admet-2089 31 25 because because SCONJ admet-2089 31 26 they they PRON admet-2089 31 27 are be AUX admet-2089 31 28 biodegradable biodegradable ADJ admet-2089 31 29 , , PUNCT admet-2089 31 30 biocompatible biocompatible ADJ admet-2089 31 31 and and CCONJ admet-2089 31 32 nontoxic nontoxic ADJ admet-2089 32 1 [ [ X admet-2089 32 2 13,14 13,14 NUM admet-2089 32 3 ] ] PUNCT admet-2089 32 4 . . PUNCT admet-2089 33 1 they they PRON admet-2089 33 2 have have AUX admet-2089 33 3 proved prove VERB admet-2089 33 4 to to PART admet-2089 33 5 be be AUX admet-2089 33 6 efficient efficient ADJ admet-2089 33 7 carriers carrier NOUN admet-2089 33 8 as as ADV admet-2089 33 9 well well ADV admet-2089 33 10 as as ADP admet-2089 33 11 immune immune ADJ admet-2089 33 12 potentiators potentiator NOUN admet-2089 33 13 by by ADP admet-2089 33 14 inducing induce VERB admet-2089 33 15 balanced balanced ADJ admet-2089 33 16 th1 th1 PROPN admet-2089 33 17 & & CCONJ admet-2089 33 18 th2 th2 PROPN admet-2089 33 19 responses response VERB admet-2089 33 20 [ [ X admet-2089 33 21 15 15 NUM admet-2089 33 22 - - SYM admet-2089 33 23 17 17 NUM admet-2089 33 24 ] ] PUNCT admet-2089 33 25 . . PUNCT admet-2089 34 1 simple simple ADJ admet-2089 34 2 liposomes liposome NOUN admet-2089 34 3 formed form VERB admet-2089 34 4 from from ADP admet-2089 34 5 phosphatidylcholine phosphatidylcholine NOUN admet-2089 34 6 and and CCONJ admet-2089 34 7 cholesterol cholesterol NOUN admet-2089 34 8 , , PUNCT admet-2089 34 9 the the DET admet-2089 34 10 natural natural ADJ admet-2089 34 11 composition composition NOUN admet-2089 34 12 of of ADP admet-2089 34 13 the the DET admet-2089 34 14 human human ADJ admet-2089 34 15 cell cell NOUN admet-2089 34 16 membrane membrane NOUN admet-2089 34 17 , , PUNCT admet-2089 34 18 stimulate stimulate VERB admet-2089 34 19 efficient efficient ADJ admet-2089 34 20 immune immune ADJ admet-2089 34 21 response response NOUN admet-2089 34 22 [ [ X admet-2089 34 23 15,18 15,18 NUM admet-2089 34 24 ] ] X admet-2089 34 25 . . PUNCT admet-2089 35 1 since since SCONJ admet-2089 35 2 liposomes liposome NOUN admet-2089 35 3 are be AUX admet-2089 35 4 a a DET admet-2089 35 5 stable stable ADJ admet-2089 35 6 carrier carrier NOUN admet-2089 35 7 , , PUNCT admet-2089 35 8 they they PRON admet-2089 35 9 can can AUX admet-2089 35 10 enhance enhance VERB admet-2089 35 11 the the DET admet-2089 35 12 stability stability NOUN admet-2089 35 13 and and CCONJ admet-2089 35 14 bioavailability bioavailability NOUN admet-2089 35 15 of of ADP admet-2089 35 16 filarial filarial ADJ admet-2089 35 17 antigens antigen NOUN admet-2089 35 18 , , PUNCT admet-2089 35 19 thereby thereby ADV admet-2089 35 20 improving improve VERB admet-2089 35 21 the the DET admet-2089 35 22 prophylactic prophylactic ADJ admet-2089 35 23 behaviour behaviour NOUN admet-2089 35 24 of of ADP admet-2089 35 25 trx trx PROPN admet-2089 35 26 . . PUNCT admet-2089 36 1 the the DET admet-2089 36 2 main main ADJ admet-2089 36 3 objective objective NOUN admet-2089 36 4 of of ADP admet-2089 36 5 this this DET admet-2089 36 6 study study NOUN admet-2089 36 7 is be AUX admet-2089 36 8 to to PART admet-2089 36 9 develop develop VERB admet-2089 36 10 stable stable ADJ admet-2089 36 11 liposomal liposomal ADJ admet-2089 36 12 vehicles vehicle NOUN admet-2089 36 13 using use VERB admet-2089 36 14 epc epc PROPN admet-2089 36 15 and and CCONJ admet-2089 36 16 cholesterol cholesterol NOUN admet-2089 36 17 in in ADP admet-2089 36 18 different different ADJ admet-2089 36 19 weight weight NOUN admet-2089 36 20 ratios ratio NOUN admet-2089 36 21 . . PUNCT admet-2089 37 1 these these DET admet-2089 37 2 nano nano NOUN admet-2089 37 3 - - PUNCT admet-2089 37 4 liposomes liposome NOUN admet-2089 37 5 will will AUX admet-2089 37 6 be be AUX admet-2089 37 7 characterized characterize VERB admet-2089 37 8 and and CCONJ admet-2089 37 9 tested test VERB admet-2089 37 10 for for ADP admet-2089 37 11 their their PRON admet-2089 37 12 encapsulation encapsulation NOUN admet-2089 37 13 efficiencies efficiency NOUN admet-2089 37 14 by by ADP admet-2089 37 15 incorporating incorporate VERB admet-2089 37 16 antigen antigen ADV admet-2089 37 17 bm bm PROPN admet-2089 37 18 - - NOUN admet-2089 37 19 trx trx NOUN admet-2089 37 20 in in ADP admet-2089 37 21 various various ADJ admet-2089 37 22 lipid lipid NOUN admet-2089 37 23 : : PUNCT admet-2089 37 24 antigen antigen ADJ admet-2089 37 25 ratios ratio NOUN admet-2089 37 26 . . PUNCT admet-2089 38 1 additionally additionally ADV admet-2089 38 2 , , PUNCT admet-2089 38 3 the the DET admet-2089 38 4 stability stability NOUN admet-2089 38 5 of of ADP admet-2089 38 6 the the DET admet-2089 38 7 liposomes liposome NOUN admet-2089 38 8 will will AUX admet-2089 38 9 be be AUX admet-2089 38 10 assessed assess VERB admet-2089 38 11 through through ADP admet-2089 38 12 an an DET admet-2089 38 13 analysis analysis NOUN admet-2089 38 14 of of ADP admet-2089 38 15 the the DET admet-2089 38 16 antigen antigen ADJ admet-2089 38 17 release release NOUN admet-2089 38 18 kinetics kinetic NOUN admet-2089 38 19 . . PUNCT admet-2089 39 1 experimental experimental ADJ admet-2089 39 2 production production NOUN admet-2089 39 3 of of ADP admet-2089 39 4 filarial filarial ADJ admet-2089 39 5 antigens antigen NOUN admet-2089 39 6 the the DET admet-2089 39 7 brugia brugia ADJ admet-2089 39 8 malayi malayi VERB admet-2089 39 9 prsetb prsetb PROPN admet-2089 39 10 - - PUNCT admet-2089 39 11 trx trx NOUN admet-2089 39 12 construct construct NOUN admet-2089 39 13 was be AUX admet-2089 39 14 overexpressed overexpresse VERB admet-2089 39 15 in in ADP admet-2089 39 16 e. e. PROPN admet-2089 39 17 coli coli PROPN admet-2089 39 18 ( ( PUNCT admet-2089 39 19 gj1158 gj1158 NOUN admet-2089 39 20 ) ) PUNCT admet-2089 39 21 strain strain NOUN admet-2089 39 22 using use VERB admet-2089 39 23 nacl nacl ADJ admet-2089 39 24 induction induction NOUN admet-2089 39 25 and and CCONJ admet-2089 39 26 the the DET admet-2089 39 27 recombinant recombinant ADJ admet-2089 39 28 protein protein NOUN admet-2089 39 29 was be AUX admet-2089 39 30 purified purify VERB admet-2089 39 31 by by ADP admet-2089 39 32 ion ion NOUN admet-2089 39 33 - - PUNCT admet-2089 39 34 exchange exchange NOUN admet-2089 39 35 chromatography chromatography NOUN admet-2089 39 36 using use VERB admet-2089 39 37 q q NOUN admet-2089 39 38 - - PUNCT admet-2089 39 39 sepharose sepharose NOUN admet-2089 39 40 ( ( PUNCT admet-2089 39 41 amersham amersham PROPN admet-2089 39 42 pharmacia pharmacia PROPN admet-2089 39 43 biotech biotech NOUN admet-2089 39 44 ) ) PUNCT admet-2089 39 45 under under ADP admet-2089 39 46 non non ADJ admet-2089 39 47 - - ADJ admet-2089 39 48 denaturing denaturing ADJ admet-2089 39 49 conditions condition NOUN admet-2089 40 1 [ [ X admet-2089 40 2 7 7 NUM admet-2089 40 3 ] ] PUNCT admet-2089 40 4 . . PUNCT admet-2089 41 1 preparation preparation NOUN admet-2089 41 2 of of ADP admet-2089 41 3 nano nano NOUN admet-2089 41 4 - - PUNCT admet-2089 41 5 liposomes liposome NOUN admet-2089 41 6 the the DET admet-2089 41 7 empty empty ADJ admet-2089 41 8 liposome liposome NOUN admet-2089 41 9 was be AUX admet-2089 41 10 prepared prepare VERB admet-2089 41 11 using use VERB admet-2089 41 12 a a DET admet-2089 41 13 modified modified ADJ admet-2089 41 14 thin thin ADJ admet-2089 41 15 film film NOUN admet-2089 41 16 hydration hydration NOUN admet-2089 41 17 technique technique NOUN admet-2089 41 18 . . PUNCT admet-2089 42 1 briefly briefly NOUN admet-2089 42 2 1 1 NUM admet-2089 42 3 mg mg NOUN admet-2089 42 4 ml-1 ml-1 PRON admet-2089 42 5 of of ADP admet-2089 42 6 egg egg NOUN admet-2089 42 7 phosphatidylcholine phosphatidylcholine NOUN admet-2089 42 8 ( ( PUNCT admet-2089 42 9 epc epc PROPN admet-2089 42 10 ) ) PUNCT admet-2089 42 11 from from ADP admet-2089 42 12 sigma sigma PROPN admet-2089 42 13 - - PUNCT admet-2089 42 14 aldrich aldrich PROPN admet-2089 42 15 , , PUNCT admet-2089 42 16 usa usa PROPN admet-2089 42 17 , , PUNCT admet-2089 42 18 dissolved dissolve VERB admet-2089 42 19 in in ADP admet-2089 42 20 chloroform chloroform NOUN admet-2089 42 21 , , PUNCT admet-2089 42 22 was be AUX admet-2089 42 23 taken take VERB admet-2089 42 24 in in ADP admet-2089 42 25 a a DET admet-2089 42 26 clean clean ADJ admet-2089 42 27 , , PUNCT admet-2089 42 28 moisturefree moisturefree ADJ admet-2089 42 29 vial vial ADJ admet-2089 42 30 and and CCONJ admet-2089 42 31 purged purge VERB admet-2089 42 32 with with ADP admet-2089 42 33 nitrogen nitrogen NOUN admet-2089 42 34 gas gas NOUN admet-2089 42 35 to to PART admet-2089 42 36 remove remove VERB admet-2089 42 37 the the DET admet-2089 42 38 solvent solvent NOUN admet-2089 42 39 . . PUNCT admet-2089 43 1 the the DET admet-2089 43 2 thin thin ADJ admet-2089 43 3 film film NOUN admet-2089 43 4 formed form VERB admet-2089 43 5 is be AUX admet-2089 43 6 then then ADV admet-2089 43 7 hydrated hydrated ADJ admet-2089 43 8 with with ADP admet-2089 43 9 phosphate phosphate ADJ admet-2089 43 10 buffer buffer NOUN admet-2089 43 11 saline saline NOUN admet-2089 43 12 ( ( PUNCT admet-2089 43 13 pbs pbs PROPN admet-2089 43 14 , , PUNCT admet-2089 43 15 ph ph VERB admet-2089 43 16 7.4 7.4 NUM admet-2089 43 17 ) ) PUNCT admet-2089 43 18 . . PUNCT admet-2089 44 1 the the DET admet-2089 44 2 vial vial ADJ admet-2089 44 3 was be AUX admet-2089 44 4 stirred stir VERB admet-2089 44 5 continuously continuously ADV admet-2089 44 6 at at ADP admet-2089 44 7 60 60 NUM admet-2089 44 8 ° ° ADP admet-2089 44 9 c c NOUN admet-2089 44 10 for for ADP admet-2089 44 11 30 30 NUM admet-2089 44 12 min min NOUN admet-2089 44 13 . . PUNCT admet-2089 45 1 the the DET admet-2089 45 2 solution solution NOUN admet-2089 45 3 was be AUX admet-2089 45 4 then then ADV admet-2089 45 5 probe probe NOUN admet-2089 45 6 sonicated sonicate VERB admet-2089 45 7 for for ADP admet-2089 45 8 various various ADJ admet-2089 45 9 cycles cycle NOUN admet-2089 45 10 ( ( PUNCT admet-2089 45 11 5 5 NUM admet-2089 45 12 , , PUNCT admet-2089 45 13 10 10 NUM admet-2089 45 14 , , PUNCT admet-2089 45 15 15 15 NUM admet-2089 45 16 , , PUNCT admet-2089 45 17 20 20 NUM admet-2089 45 18 , , PUNCT admet-2089 45 19 25 25 NUM admet-2089 45 20 ) ) PUNCT admet-2089 45 21 to to PART admet-2089 45 22 obtain obtain VERB admet-2089 45 23 nano nano NOUN admet-2089 45 24 - - PUNCT admet-2089 45 25 scaled scale VERB admet-2089 45 26 liposomes liposome NOUN admet-2089 45 27 . . PUNCT admet-2089 46 1 the the DET admet-2089 46 2 sonication sonication NOUN admet-2089 46 3 was be AUX admet-2089 46 4 carried carry VERB admet-2089 46 5 out out ADP admet-2089 46 6 at at ADP admet-2089 46 7 30 30 NUM admet-2089 46 8 khz khz NOUN admet-2089 46 9 processing processing NOUN admet-2089 46 10 frequency frequency NOUN admet-2089 46 11 with with ADP admet-2089 46 12 a a DET admet-2089 46 13 cycle cycle NOUN admet-2089 46 14 duration duration NOUN admet-2089 46 15 of of ADP admet-2089 46 16 30 30 NUM admet-2089 46 17 s s NOUN admet-2089 46 18 on on ADP admet-2089 46 19 and and CCONJ admet-2089 46 20 30 30 NUM admet-2089 46 21 s s NOUN admet-2089 46 22 break break NOUN admet-2089 46 23 to to PART admet-2089 46 24 cool cool VERB admet-2089 46 25 down down ADP admet-2089 46 26 the the DET admet-2089 46 27 sample sample NOUN admet-2089 46 28 . . PUNCT admet-2089 47 1 the the DET admet-2089 47 2 heat heat NOUN admet-2089 47 3 released release VERB admet-2089 47 4 by by ADP admet-2089 47 5 sonication sonication NOUN admet-2089 47 6 was be AUX admet-2089 47 7 cooled cool VERB admet-2089 47 8 by by ADP admet-2089 47 9 immersing immerse VERB admet-2089 47 10 the the DET admet-2089 47 11 vial vial NOUN admet-2089 47 12 in in ADP admet-2089 47 13 a a DET admet-2089 47 14 beaker beaker NOUN admet-2089 47 15 full full ADJ admet-2089 47 16 of of ADP admet-2089 47 17 ice ice NOUN admet-2089 47 18 water water NOUN admet-2089 47 19 . . PUNCT admet-2089 48 1 size size NOUN admet-2089 48 2 and and CCONJ admet-2089 48 3 morphology morphology NOUN admet-2089 48 4 characterization characterization NOUN admet-2089 48 5 of of ADP admet-2089 48 6 liposomes liposome NOUN admet-2089 48 7 the the DET admet-2089 48 8 size size NOUN admet-2089 48 9 and and CCONJ admet-2089 48 10 uniform uniform ADJ admet-2089 48 11 distribution distribution NOUN admet-2089 48 12 of of ADP admet-2089 48 13 prepared prepared ADJ admet-2089 48 14 liposomes liposome NOUN admet-2089 48 15 were be AUX admet-2089 48 16 confirmed confirm VERB admet-2089 48 17 using use VERB admet-2089 48 18 dynamic dynamic ADJ admet-2089 48 19 light light NOUN admet-2089 48 20 scattering scattering NOUN admet-2089 48 21 ( ( PUNCT admet-2089 48 22 dls dls NOUN admet-2089 48 23 ) ) PUNCT admet-2089 48 24 instruments instrument NOUN admet-2089 48 25 . . PUNCT admet-2089 49 1 the the DET admet-2089 49 2 transmission transmission NOUN admet-2089 49 3 electron electron NOUN admet-2089 49 4 micrographs micrograph NOUN admet-2089 49 5 of of ADP admet-2089 49 6 lyophilized lyophilized ADJ admet-2089 49 7 nano nano NOUN admet-2089 49 8 - - PUNCT admet-2089 49 9 liposomes liposome NOUN admet-2089 49 10 formed form VERB admet-2089 49 11 with with ADP admet-2089 49 12 an an DET admet-2089 49 13 optimised optimise VERB admet-2089 49 14 cycle cycle NOUN admet-2089 49 15 of of ADP admet-2089 49 16 sonication sonication NOUN admet-2089 49 17 were be AUX admet-2089 49 18 re re VERB admet-2089 49 19 - - VERB admet-2089 49 20 suspended suspend VERB admet-2089 49 21 in in ADP admet-2089 49 22 double double ADJ admet-2089 49 23 distilled distil VERB admet-2089 49 24 water water NOUN admet-2089 49 25 and and CCONJ admet-2089 49 26 1 1 NUM admet-2089 49 27 µl µl NOUN admet-2089 49 28 of of ADP admet-2089 49 29 this this DET admet-2089 49 30 dispersion dispersion NOUN admet-2089 49 31 was be AUX admet-2089 49 32 https://paperpile.com/c/plxgz5/shx33+bohsx https://paperpile.com/c/plxgz5/shx33+bohsx PROPN admet-2089 49 33 https://paperpile.com/c/plxgz5/r0sgz https://paperpile.com/c/plxgz5/r0sgz PROPN admet-2089 49 34 https://paperpile.com/c/plxgz5/ajede https://paperpile.com/c/plxgz5/ajede NOUN admet-2089 49 35 https://paperpile.com/c/plxgz5/itnc8+9xqs1 https://paperpile.com/c/plxgz5/itnc8+9xqs1 PRON admet-2089 49 36 https://paperpile.com/c/plxgz5/dchei+n8pw6 https://paperpile.com/c/plxgz5/dchei+n8pw6 ADV admet-2089 49 37 https://paperpile.com/c/plxgz5/gwxum https://paperpile.com/c/plxgz5/gwxum VERB admet-2089 49 38 https://paperpile.com/c/plxgz5/wnlht+fbxza https://paperpile.com/c/plxgz5/wnlht+fbxza ADJ admet-2089 49 39 https://paperpile.com/c/plxgz5/4fpkb+l6eug+wg1ja https://paperpile.com/c/plxgz5/4fpkb+l6eug+wg1ja PROPN admet-2089 49 40 https://paperpile.com/c/plxgz5/4fpkb+9uu2q https://paperpile.com/c/plxgz5/4fpkb+9uu2q PROPN admet-2089 49 41 https://paperpile.com/c/plxgz5/ajede https://paperpile.com/c/plxgz5/ajede PROPN admet-2089 49 42 admet admet PROPN admet-2089 49 43 & & CCONJ admet-2089 49 44 dmpk dmpk PROPN admet-2089 49 45 12(2 12(2 NUM admet-2089 49 46 ) ) PUNCT admet-2089 49 47 ( ( PUNCT admet-2089 49 48 2024 2024 NUM admet-2089 49 49 ) ) PUNCT admet-2089 49 50 379 379 NUM admet-2089 49 51 - - SYM admet-2089 49 52 389 389 NUM admet-2089 49 53 encapsulation encapsulation NOUN admet-2089 49 54 of of ADP admet-2089 49 55 brugia brugia ADJ admet-2089 49 56 malayi malayi VERB admet-2089 49 57 thioredoxin thioredoxin PROPN admet-2089 49 58 in in ADP admet-2089 49 59 nano nano NOUN admet-2089 49 60 - - PUNCT admet-2089 49 61 liposomes liposome NOUN admet-2089 49 62 doi doi NOUN admet-2089 49 63 : : PUNCT admet-2089 49 64 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 49 65 381 381 NUM admet-2089 49 66 placed place VERB admet-2089 49 67 on on ADP admet-2089 49 68 the the DET admet-2089 49 69 grid grid NOUN admet-2089 49 70 , , PUNCT admet-2089 49 71 air air NOUN admet-2089 49 72 dried dry VERB admet-2089 49 73 and and CCONJ admet-2089 49 74 then then ADV admet-2089 49 75 loaded load VERB admet-2089 49 76 into into ADP admet-2089 49 77 the the DET admet-2089 49 78 specimen speciman NOUN admet-2089 49 79 chamber chamber NOUN admet-2089 49 80 . . PUNCT admet-2089 50 1 the the DET admet-2089 50 2 tem tem PROPN admet-2089 50 3 images image NOUN admet-2089 50 4 were be AUX admet-2089 50 5 obtained obtain VERB admet-2089 50 6 using use VERB admet-2089 50 7 jeol jeol PROPN admet-2089 50 8 jem jem PROPN admet-2089 50 9 -200cx -200cx PROPN admet-2089 51 1 at at ADP admet-2089 51 2 60kv 60kv ADJ admet-2089 51 3 . . PUNCT admet-2089 52 1 filarial filarial ADJ admet-2089 52 2 antigen antigen ADJ admet-2089 52 3 loading loading NOUN admet-2089 52 4 in in ADP admet-2089 52 5 order order NOUN admet-2089 52 6 to to PART admet-2089 52 7 determine determine VERB admet-2089 52 8 high high ADJ admet-2089 52 9 encapsulation encapsulation NOUN admet-2089 52 10 efficiency efficiency NOUN admet-2089 52 11 , , PUNCT admet-2089 52 12 various various ADJ admet-2089 52 13 concentrations concentration NOUN admet-2089 52 14 of of ADP admet-2089 52 15 epc epc PROPN admet-2089 52 16 and and CCONJ admet-2089 52 17 cholesterol cholesterol NOUN admet-2089 52 18 ( ( PUNCT admet-2089 52 19 ch ch NOUN admet-2089 52 20 ) ) PUNCT admet-2089 52 21 in in ADP admet-2089 52 22 weight weight NOUN admet-2089 52 23 ratios ratio NOUN admet-2089 52 24 of of ADP admet-2089 52 25 10:0 10:0 NUM admet-2089 52 26 , , PUNCT admet-2089 52 27 9:1 9:1 NUM admet-2089 52 28 , , PUNCT admet-2089 52 29 8:2 8:2 NUM admet-2089 52 30 , , PUNCT admet-2089 52 31 7:3 7:3 NUM admet-2089 52 32 , , PUNCT admet-2089 52 33 6:4 6:4 NUM admet-2089 52 34 of of ADP admet-2089 52 35 5:5 5:5 NUM admet-2089 52 36 were be AUX admet-2089 52 37 analysed analyse VERB admet-2089 52 38 . . PUNCT admet-2089 53 1 the the DET admet-2089 53 2 phospholipids phospholipid NOUN admet-2089 53 3 ( ( PUNCT admet-2089 53 4 epc epc PROPN admet-2089 53 5 : : PUNCT admet-2089 53 6 ch ch NOUN admet-2089 53 7 ) ) PUNCT admet-2089 53 8 of of ADP admet-2089 53 9 various various ADJ admet-2089 53 10 combinations combination NOUN admet-2089 53 11 were be AUX admet-2089 53 12 taken take VERB admet-2089 53 13 in in ADP admet-2089 53 14 sterile sterile ADJ admet-2089 53 15 vials vial NOUN admet-2089 53 16 and and CCONJ admet-2089 53 17 purged purge VERB admet-2089 53 18 . . PUNCT admet-2089 54 1 the the DET admet-2089 54 2 various various ADJ admet-2089 54 3 weight weight NOUN admet-2089 54 4 ratios ratio NOUN admet-2089 54 5 of of ADP admet-2089 54 6 phospholipids phospholipid NOUN admet-2089 54 7 were be AUX admet-2089 54 8 evaluated evaluate VERB admet-2089 54 9 for for ADP admet-2089 54 10 their their PRON admet-2089 54 11 efficacy efficacy NOUN admet-2089 54 12 in in ADP admet-2089 54 13 encapsulating encapsulate VERB admet-2089 54 14 recombinant recombinant ADJ admet-2089 54 15 protein protein NOUN admet-2089 54 16 bm bm PROPN admet-2089 54 17 - - NOUN admet-2089 54 18 trx trx PROPN admet-2089 54 19 in in ADP admet-2089 54 20 the the DET admet-2089 54 21 following follow VERB admet-2089 54 22 weight weight NOUN admet-2089 54 23 ratios ratio NOUN admet-2089 54 24 : : PUNCT admet-2089 54 25 10:1 10:1 NUM admet-2089 54 26 , , PUNCT admet-2089 54 27 10:2 10:2 NUM admet-2089 54 28 and and CCONJ admet-2089 54 29 10:3 10:3 NOUN admet-2089 54 30 . . PUNCT admet-2089 55 1 antigens antigen NOUN admet-2089 55 2 in in ADP admet-2089 55 3 pbs pbs PROPN admet-2089 55 4 ( ( PUNCT admet-2089 55 5 ph ph NOUN admet-2089 55 6 7.4 7.4 NUM admet-2089 55 7 ) ) PUNCT admet-2089 55 8 were be AUX admet-2089 55 9 taken take VERB admet-2089 55 10 and and CCONJ admet-2089 55 11 added add VERB admet-2089 55 12 to to ADP admet-2089 55 13 the the DET admet-2089 55 14 purged purged ADJ admet-2089 55 15 lipids lipid NOUN admet-2089 55 16 . . PUNCT admet-2089 56 1 it it PRON admet-2089 56 2 was be AUX admet-2089 56 3 then then ADV admet-2089 56 4 stirred stir VERB admet-2089 56 5 for for ADP admet-2089 56 6 30 30 NUM admet-2089 56 7 min min NOUN admet-2089 56 8 at at ADP admet-2089 56 9 60 60 NUM admet-2089 56 10 ° ° ADP admet-2089 56 11 c c NOUN admet-2089 56 12 and and CCONJ admet-2089 56 13 sonicated sonicate VERB admet-2089 56 14 to to PART admet-2089 56 15 form form VERB admet-2089 56 16 trx trx NOUN admet-2089 56 17 - - PUNCT admet-2089 56 18 loaded load VERB admet-2089 56 19 nano nano NOUN admet-2089 56 20 - - PUNCT admet-2089 56 21 liposome liposome NOUN admet-2089 56 22 ( ( PUNCT admet-2089 56 23 tl tl PROPN admet-2089 56 24 ) ) PUNCT admet-2089 56 25 . . PUNCT admet-2089 57 1 determination determination NOUN admet-2089 57 2 of of ADP admet-2089 57 3 encapsulation encapsulation NOUN admet-2089 57 4 efficiency efficiency NOUN admet-2089 57 5 the the DET admet-2089 57 6 sonicated sonicate VERB admet-2089 57 7 liposomes liposome NOUN admet-2089 57 8 were be AUX admet-2089 57 9 centrifuged centrifuge VERB admet-2089 57 10 at at ADP admet-2089 57 11 10,000 10,000 NUM admet-2089 57 12 rpm rpm NOUN admet-2089 57 13 at at ADP admet-2089 57 14 4 4 NUM admet-2089 57 15 ° ° ADP admet-2089 57 16 c c NOUN admet-2089 57 17 for for ADP admet-2089 57 18 10 10 NUM admet-2089 57 19 min min NOUN admet-2089 57 20 to to PART admet-2089 57 21 separate separate VERB admet-2089 57 22 unbound unbound NOUN admet-2089 57 23 trx trx NOUN admet-2089 57 24 from from ADP admet-2089 57 25 the the DET admet-2089 57 26 loaded load VERB admet-2089 57 27 liposomes liposome NOUN admet-2089 57 28 . . PUNCT admet-2089 58 1 the the DET admet-2089 58 2 liposomes liposome NOUN admet-2089 58 3 were be AUX admet-2089 58 4 washed wash VERB admet-2089 58 5 with with ADP admet-2089 58 6 pbs pbs PROPN admet-2089 58 7 ( ( PUNCT admet-2089 58 8 ph ph NOUN admet-2089 58 9 7.4 7.4 NUM admet-2089 58 10 ) ) PUNCT admet-2089 58 11 until until SCONJ admet-2089 58 12 no no DET admet-2089 58 13 protein protein NOUN admet-2089 58 14 was be AUX admet-2089 58 15 found find VERB admet-2089 58 16 in in ADP admet-2089 58 17 the the DET admet-2089 58 18 supernatant supernatant NOUN admet-2089 58 19 . . PUNCT admet-2089 59 1 the the DET admet-2089 59 2 presence presence NOUN admet-2089 59 3 of of ADP admet-2089 59 4 trx trx NOUN admet-2089 59 5 in in ADP admet-2089 59 6 supernatant supernatant NOUN admet-2089 59 7 was be AUX admet-2089 59 8 estimated estimate VERB admet-2089 59 9 using use VERB admet-2089 59 10 the the DET admet-2089 59 11 bca bca PROPN admet-2089 59 12 method method NOUN admet-2089 59 13 . . PUNCT admet-2089 60 1 all all DET admet-2089 60 2 the the DET admet-2089 60 3 experiments experiment NOUN admet-2089 60 4 were be AUX admet-2089 60 5 carried carry VERB admet-2089 60 6 out out ADP admet-2089 60 7 in in ADP admet-2089 60 8 triplicates triplicate NOUN admet-2089 60 9 . . PUNCT admet-2089 61 1 the the DET admet-2089 61 2 encapsulation encapsulation NOUN admet-2089 61 3 efficiency efficiency NOUN admet-2089 61 4 was be AUX admet-2089 61 5 estimated estimate VERB admet-2089 61 6 using use VERB admet-2089 61 7 the the DET admet-2089 61 8 formulae formulae NOUN admet-2089 61 9 given give VERB admet-2089 61 10 in in ADP admet-2089 61 11 equation equation NOUN admet-2089 61 12 ( ( PUNCT admet-2089 61 13 1 1 NUM admet-2089 61 14 ) ) PUNCT admet-2089 61 15 . . PUNCT admet-2089 62 1 total total ADJ admet-2089 62 2     SPACE admet-2089 62 3 concentration concentration NOUN admet-2089 62 4     SPACE admet-2089 62 5 of of ADP admet-2089 62 6     SPACE admet-2089 62 7 trx trx NOUN admet-2089 62 8     SPACE admet-2089 62 9 added add VERB admet-2089 62 10 - - PUNCT admet-2089 62 11 concentration concentration NOUN admet-2089 62 12     SPACE admet-2089 62 13 of of ADP admet-2089 62 14     SPACE admet-2089 62 15 trx trx NOUN admet-2089 62 16     SPACE admet-2089 62 17 in in ADP admet-2089 62 18     SPACE admet-2089 62 19 the the DET admet-2089 62 20     SPACE admet-2089 62 21 supernatant supernatant NOUN admet-2089 62 22 encapsulation encapsulation NOUN admet-2089 62 23     SPACE admet-2089 62 24 efficiency efficiency NOUN admet-2089 62 25 , , PUNCT admet-2089 62 26     SPACE admet-2089 62 27 % % NOUN admet-2089 63 1 = = NOUN admet-2089 63 2           SPACE admet-2089 63 3 100 100 NUM admet-2089 63 4       SPACE admet-2089 63 5 total total ADJ admet-2089 63 6     SPACE admet-2089 63 7 concentration concentration NOUN admet-2089 63 8     SPACE admet-2089 63 9 of of ADP admet-2089 63 10     SPACE admet-2089 63 11 trx trx X admet-2089 63 12 ( ( PUNCT admet-2089 63 13 1 1 X admet-2089 63 14 ) ) PUNCT admet-2089 63 15 release release NOUN admet-2089 63 16 kinetics kinetic NOUN admet-2089 63 17 1 1 NUM admet-2089 63 18 mg mg ADP admet-2089 63 19 of of ADP admet-2089 63 20 lyophilised lyophilise VERB admet-2089 63 21 tl tl PROPN admet-2089 63 22 having have VERB admet-2089 63 23 good good ADJ admet-2089 63 24 encapsulation encapsulation NOUN admet-2089 63 25 was be AUX admet-2089 63 26 suspended suspend VERB admet-2089 63 27 in in ADP admet-2089 63 28 1 1 NUM admet-2089 63 29 ml ml NOUN admet-2089 63 30 pbs pbs PROPN admet-2089 63 31 ( ( PUNCT admet-2089 63 32 ph ph NOUN admet-2089 63 33 7.4 7.4 NUM admet-2089 63 34 ) ) PUNCT admet-2089 63 35 and and CCONJ admet-2089 63 36 incubated incubate VERB admet-2089 63 37 at at ADP admet-2089 63 38 37 37 NUM admet-2089 63 39 ° ° NOUN admet-2089 63 40 c c NOUN admet-2089 63 41 under under ADP admet-2089 63 42 mild mild ADJ admet-2089 63 43 agitation agitation NOUN admet-2089 63 44 in in ADP admet-2089 63 45 different different ADJ admet-2089 63 46 containers container NOUN admet-2089 63 47 . . PUNCT admet-2089 64 1 at at ADP admet-2089 64 2 a a DET admet-2089 64 3 predetermined predetermine VERB admet-2089 64 4 time time NOUN admet-2089 64 5 interval interval NOUN admet-2089 64 6 , , PUNCT admet-2089 64 7 a a DET admet-2089 64 8 container container NOUN admet-2089 64 9 was be AUX admet-2089 64 10 taken take VERB admet-2089 64 11 out out ADP admet-2089 64 12 and and CCONJ admet-2089 64 13 centrifuged centrifuge VERB admet-2089 64 14 at at ADP admet-2089 64 15 10,000 10,000 NUM admet-2089 64 16 rpm rpm NOUN admet-2089 64 17 for for ADP admet-2089 64 18 10 10 NUM admet-2089 64 19 min min NOUN admet-2089 64 20 to to PART admet-2089 64 21 separate separate VERB admet-2089 64 22 the the DET admet-2089 64 23 released release VERB admet-2089 64 24 antigen antigen ADV admet-2089 64 25 from from ADP admet-2089 64 26 encapsulated encapsulate VERB admet-2089 64 27 liposomes liposome NOUN admet-2089 64 28 . . PUNCT admet-2089 65 1 the the DET admet-2089 65 2 release release NOUN admet-2089 65 3 was be AUX admet-2089 65 4 determined determine VERB admet-2089 65 5 using use VERB admet-2089 65 6 the the DET admet-2089 65 7 formulae formulae NOUN admet-2089 65 8 given give VERB admet-2089 65 9 in in ADP admet-2089 65 10 equation equation NOUN admet-2089 65 11 ( ( PUNCT admet-2089 65 12 2 2 NUM admet-2089 65 13 ) ) PUNCT admet-2089 65 14 . . PUNCT admet-2089 66 1 cocnetration cocnetration NOUN admet-2089 66 2     SPACE admet-2089 66 3 of of ADP admet-2089 66 4     SPACE admet-2089 66 5 trx trx NOUN admet-2089 66 6     SPACE admet-2089 66 7 in in ADP admet-2089 66 8     SPACE admet-2089 66 9 the the DET admet-2089 66 10     SPACE admet-2089 66 11 supernatant supernatant NOUN admet-2089 66 12     SPACE admet-2089 66 13 at at ADP admet-2089 66 14     SPACE admet-2089 66 15 time time NOUN admet-2089 66 16         SPACE admet-2089 66 17 release release NOUN admet-2089 66 18 , , PUNCT admet-2089 66 19     SPACE admet-2089 66 20 % % NOUN admet-2089 66 21 = = NOUN admet-2089 66 22         SPACE admet-2089 66 23 100 100 NUM admet-2089 66 24       SPACE admet-2089 66 25 concentration concentration NOUN admet-2089 66 26     SPACE admet-2089 66 27 of of ADP admet-2089 66 28     SPACE admet-2089 66 29 total total NOUN admet-2089 66 30     SPACE admet-2089 66 31 encapsulated encapsulate VERB admet-2089 66 32     SPACE admet-2089 66 33 entigen entigen PROPN admet-2089 66 34 t t PROPN admet-2089 66 35 ( ( PUNCT admet-2089 66 36 2 2 NUM admet-2089 66 37 ) ) PUNCT admet-2089 66 38 in in ADP admet-2089 66 39 silico silico NOUN admet-2089 66 40 analysis analysis NOUN admet-2089 66 41 protein protein NOUN admet-2089 66 42 retrieval retrieval NOUN admet-2089 66 43 , , PUNCT admet-2089 66 44 modelling modelling NOUN admet-2089 66 45 and and CCONJ admet-2089 66 46 validation validation NOUN admet-2089 66 47 for for ADP admet-2089 66 48 the the DET admet-2089 66 49 current current ADJ admet-2089 66 50 study study NOUN admet-2089 66 51 , , PUNCT admet-2089 66 52 the the DET admet-2089 66 53 protein protein NOUN admet-2089 66 54 thioredoxin thioredoxin PROPN admet-2089 66 55 from from ADP admet-2089 66 56 brugia brugia ADJ admet-2089 66 57 malayi malayi NOUN admet-2089 66 58 was be AUX admet-2089 66 59 retrieved retrieve VERB admet-2089 66 60 from from ADP admet-2089 66 61 ncbi ncbi PROPN admet-2089 66 62 protein protein NOUN admet-2089 66 63 database database NOUN admet-2089 66 64 , , PUNCT admet-2089 66 65 whose whose DET admet-2089 66 66 accession accession NOUN admet-2089 66 67 i i PRON admet-2089 66 68 d d PROPN admet-2089 66 69 is be AUX admet-2089 66 70 aam51563.1 aam51563.1 PROPN admet-2089 66 71 . . PUNCT admet-2089 67 1 the the DET admet-2089 67 2 fasta fasta PROPN admet-2089 67 3 sequence sequence NOUN admet-2089 67 4 was be AUX admet-2089 67 5 used use VERB admet-2089 67 6 for for ADP admet-2089 67 7 further further ADJ admet-2089 67 8 analysis analysis NOUN admet-2089 67 9 . . PUNCT admet-2089 68 1 in in ADP admet-2089 68 2 order order NOUN admet-2089 68 3 to to PART admet-2089 68 4 generate generate VERB admet-2089 68 5 the the DET admet-2089 68 6 three three NUM admet-2089 68 7 - - PUNCT admet-2089 68 8 dimensional dimensional ADJ admet-2089 68 9 model model NOUN admet-2089 68 10 of of ADP admet-2089 68 11 the the DET admet-2089 68 12 protein protein NOUN admet-2089 68 13 , , PUNCT admet-2089 68 14 robetta robetta VERB admet-2089 68 15 online online PROPN admet-2089 68 16 server server NOUN admet-2089 68 17 was be AUX admet-2089 68 18 used use VERB admet-2089 68 19 . . PUNCT admet-2089 69 1 ab ab PROPN admet-2089 69 2 - - PUNCT admet-2089 69 3 initio initio NOUN admet-2089 69 4 modelling modelling NOUN admet-2089 69 5 of of ADP admet-2089 69 6 the the DET admet-2089 69 7 selected select VERB admet-2089 69 8 protein protein NOUN admet-2089 69 9 was be AUX admet-2089 69 10 performed perform VERB admet-2089 69 11 [ [ PUNCT admet-2089 69 12 19 19 NUM admet-2089 69 13 ] ] PUNCT admet-2089 69 14 . . PUNCT admet-2089 70 1 further far ADV admet-2089 70 2 , , PUNCT admet-2089 70 3 the the DET admet-2089 70 4 three three NUM admet-2089 70 5 - - PUNCT admet-2089 70 6 dimensional dimensional ADJ admet-2089 70 7 model model NOUN admet-2089 70 8 was be AUX admet-2089 70 9 validated validate VERB admet-2089 70 10 using use VERB admet-2089 70 11 ramachandran ramachandran PROPN admet-2089 70 12 plot plot NOUN admet-2089 70 13 analysed analyse VERB admet-2089 70 14 using use VERB admet-2089 70 15 saves save VERB admet-2089 70 16 v6.0 v6.0 NOUN admet-2089 70 17 and and CCONJ admet-2089 70 18 molprobity molprobity NOUN admet-2089 70 19 server server NOUN admet-2089 70 20 . . PUNCT admet-2089 71 1 the the DET admet-2089 71 2 comparative comparative ADJ admet-2089 71 3 identity identity NOUN admet-2089 71 4 of of ADP admet-2089 71 5 thioredoxin thioredoxin PROPN admet-2089 71 6 sequence sequence NOUN admet-2089 71 7 from from ADP admet-2089 71 8 brugia brugia ADJ admet-2089 71 9 malayi malayi NOUN admet-2089 71 10 was be AUX admet-2089 71 11 done do VERB admet-2089 71 12 against against ADP admet-2089 71 13 non non ADJ admet-2089 71 14 - - ADJ admet-2089 71 15 redundant redundant ADJ admet-2089 71 16 protein protein NOUN admet-2089 71 17 sequences sequence NOUN admet-2089 71 18 against against ADP admet-2089 71 19 homo homo NOUN admet-2089 71 20 sapiens sapien VERB admet-2089 71 21 present present ADJ admet-2089 71 22 in in ADP admet-2089 71 23 the the DET admet-2089 71 24 other other ADJ admet-2089 71 25 databases database NOUN admet-2089 71 26 with with ADP admet-2089 71 27 the the DET admet-2089 71 28 parameters parameter NOUN admet-2089 71 29 of of ADP admet-2089 71 30 ( ( PUNCT admet-2089 71 31 expected expect VERB admet-2089 71 32 threshold:0.05 threshold:0.05 NOUN admet-2089 71 33 , , PUNCT admet-2089 71 34 sequence sequence NOUN admet-2089 71 35 identity identity NOUN admet-2089 71 36 : : PUNCT admet-2089 71 37 ≤45 ≤45 ADJ admet-2089 71 38 % % NOUN admet-2089 71 39 ) ) PUNCT admet-2089 71 40 using use VERB admet-2089 71 41 blastp blastp PROPN admet-2089 71 42 server server NOUN admet-2089 72 1 [ [ X admet-2089 72 2 20 20 NUM admet-2089 72 3 ] ] PUNCT admet-2089 72 4 . . PUNCT admet-2089 73 1 epitope epitope PROPN admet-2089 73 2 prediction prediction NOUN admet-2089 73 3 and and CCONJ admet-2089 73 4 its its PRON admet-2089 73 5 properties property NOUN admet-2089 73 6 in in ADP admet-2089 73 7 order order NOUN admet-2089 73 8 to to PART admet-2089 73 9 identify identify VERB admet-2089 73 10 b b PRON admet-2089 73 11 cell cell NOUN admet-2089 73 12 - - PUNCT admet-2089 73 13 specific specific ADJ admet-2089 73 14 epitopes epitope NOUN admet-2089 73 15 , , PUNCT admet-2089 73 16 an an DET admet-2089 73 17 online online ADJ admet-2089 73 18 tool tool NOUN admet-2089 73 19 , , PUNCT admet-2089 73 20 abcpred abcpred ADJ admet-2089 73 21 server server NOUN admet-2089 73 22 , , PUNCT admet-2089 73 23 was be AUX admet-2089 73 24 used use VERB admet-2089 73 25 . . PUNCT admet-2089 74 1 the the DET admet-2089 74 2 prediction prediction NOUN admet-2089 74 3 was be AUX admet-2089 74 4 made make VERB admet-2089 74 5 with with ADP admet-2089 74 6 a a DET admet-2089 74 7 window window NOUN admet-2089 74 8 length length NOUN admet-2089 74 9 14 14 NUM admet-2089 74 10 and and CCONJ admet-2089 74 11 an an DET admet-2089 74 12 epitope epitope NOUN admet-2089 74 13 specificity specificity NOUN admet-2089 74 14 threshold threshold VERB admet-2089 74 15 0.51 0.51 NUM admet-2089 74 16 . . PUNCT admet-2089 75 1 the the DET admet-2089 75 2 antigenic antigenic ADJ admet-2089 75 3 properties property NOUN admet-2089 75 4 of of ADP admet-2089 75 5 the the DET admet-2089 75 6 predicted predict VERB admet-2089 75 7 epitopes epitope NOUN admet-2089 75 8 were be AUX admet-2089 75 9 evaluated evaluate VERB admet-2089 75 10 using use VERB admet-2089 75 11 the the DET admet-2089 75 12 vaxigen vaxigen ADJ admet-2089 75 13 2.0 2.0 NUM admet-2089 75 14 server server NOUN admet-2089 75 15 with with ADP admet-2089 75 16 target target NOUN admet-2089 75 17 organism organism NOUN admet-2089 75 18 as as ADP admet-2089 75 19 a a DET admet-2089 75 20 parasite parasite NOUN admet-2089 75 21 and and CCONJ admet-2089 75 22 a a DET admet-2089 75 23 cut cut VERB admet-2089 75 24 - - PUNCT admet-2089 75 25 off off ADP admet-2089 75 26 score score NOUN admet-2089 75 27 of of ADP admet-2089 75 28 0.6 0.6 NUM admet-2089 76 1 [ [ X admet-2089 76 2 21 21 NUM admet-2089 76 3 ] ] PUNCT admet-2089 76 4 . . PUNCT admet-2089 77 1 the the DET admet-2089 77 2 predicted predict VERB admet-2089 77 3 epitopes epitope NOUN admet-2089 77 4 were be AUX admet-2089 77 5 also also ADV admet-2089 77 6 checked check VERB admet-2089 77 7 for for ADP admet-2089 77 8 allergenicity allergenicity NOUN admet-2089 77 9 to to PART admet-2089 77 10 prevent prevent VERB admet-2089 77 11 undesirable undesirable ADJ admet-2089 77 12 immune immune ADJ admet-2089 77 13 reactions reaction NOUN admet-2089 77 14 . . PUNCT admet-2089 78 1 the the DET admet-2089 78 2 prediction prediction NOUN admet-2089 78 3 was be AUX admet-2089 78 4 carried carry VERB admet-2089 78 5 out out ADP admet-2089 78 6 using use VERB admet-2089 78 7 the the DET admet-2089 78 8 allergen allergen NOUN admet-2089 78 9 fp fp NOUN admet-2089 78 10 v.1.0 v.1.0 ADJ admet-2089 78 11 server server NOUN admet-2089 79 1 [ [ X admet-2089 79 2 22,23 22,23 NOUN admet-2089 79 3 ] ] PUNCT admet-2089 79 4 . . PUNCT admet-2089 80 1 conformational conformational ADJ admet-2089 80 2 epitope epitope NOUN admet-2089 80 3 prediction prediction NOUN admet-2089 80 4 of of ADP admet-2089 80 5 the the DET admet-2089 80 6 protein protein NOUN admet-2089 80 7 modelled model VERB admet-2089 80 8 was be AUX admet-2089 80 9 carried carry VERB admet-2089 80 10 out out ADP admet-2089 80 11 using use VERB admet-2089 80 12 an an DET admet-2089 80 13 epitope epitope NOUN admet-2089 80 14 3d 3d PROPN admet-2089 80 15 server server NOUN admet-2089 81 1 [ [ X admet-2089 81 2 24 24 NUM admet-2089 81 3 ] ] PUNCT admet-2089 81 4 . . PUNCT admet-2089 82 1 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 ADJ admet-2089 82 2 https://paperpile.com/c/plxgz5/cflik https://paperpile.com/c/plxgz5/cflik ADJ admet-2089 82 3 https://paperpile.com/c/plxgz5/ebooc https://paperpile.com/c/plxgz5/ebooc NOUN admet-2089 82 4 https://paperpile.com/c/plxgz5/1ctic https://paperpile.com/c/plxgz5/1ctic ADJ admet-2089 82 5 https://paperpile.com/c/plxgz5/gidq9+wqshf https://paperpile.com/c/plxgz5/gidq9+wqshf PROPN admet-2089 82 6 https://paperpile.com/c/plxgz5/jlery https://paperpile.com/c/plxgz5/jlery PROPN admet-2089 82 7 m. m. PROPN admet-2089 82 8 balasubramaniyan balasubramaniyan PROPN admet-2089 82 9 et et PROPN admet-2089 82 10 al al PROPN admet-2089 82 11 . . PROPN admet-2089 82 12 admet admet PROPN admet-2089 82 13 & & CCONJ admet-2089 82 14 dmpk dmpk PROPN admet-2089 82 15 12(2 12(2 NUM admet-2089 82 16 ) ) PUNCT admet-2089 82 17 ( ( PUNCT admet-2089 82 18 2024 2024 NUM admet-2089 82 19 ) ) PUNCT admet-2089 82 20 379 379 NUM admet-2089 82 21 - - SYM admet-2089 82 22 389 389 NUM admet-2089 82 23 382 382 NUM admet-2089 82 24 prediction prediction NOUN admet-2089 82 25 of of ADP admet-2089 82 26 mhc mhc PROPN admet-2089 82 27 class class PROPN admet-2089 82 28 i i PROPN admet-2089 82 29 and and CCONJ admet-2089 82 30 mhc mhc PROPN admet-2089 82 31 class class PROPN admet-2089 82 32 ii ii PROPN admet-2089 82 33 epitopes epitope VERB admet-2089 82 34 to to PART admet-2089 82 35 predict predict VERB admet-2089 82 36 the the DET admet-2089 82 37 peptides peptide NOUN admet-2089 82 38 binding bind VERB admet-2089 82 39 to to ADP admet-2089 82 40 major major ADJ admet-2089 82 41 histocompatibility histocompatibility NOUN admet-2089 82 42 complex1 complex1 NOUN admet-2089 82 43 ( ( PUNCT admet-2089 82 44 mhc mhc PROPN admet-2089 82 45 1 1 NUM admet-2089 82 46 ) ) PUNCT admet-2089 82 47 , , PUNCT admet-2089 82 48 the the DET admet-2089 82 49 online online ADJ admet-2089 82 50 server server NOUN admet-2089 82 51 net net ADJ admet-2089 82 52 mhc mhc PROPN admet-2089 82 53 4.0 4.0 NUM admet-2089 82 54 was be AUX admet-2089 82 55 used use VERB admet-2089 82 56 [ [ PUNCT admet-2089 82 57 25 25 NUM admet-2089 82 58 ] ] PUNCT admet-2089 82 59 . . PUNCT admet-2089 83 1 the the DET admet-2089 83 2 predicted predict VERB admet-2089 83 3 epitope epitope PROPN admet-2089 83 4 sequences sequence NOUN admet-2089 83 5 were be AUX admet-2089 83 6 given give VERB admet-2089 83 7 as as ADP admet-2089 83 8 input input NOUN admet-2089 83 9 with with ADP admet-2089 83 10 a a DET admet-2089 83 11 peptide peptide ADJ admet-2089 83 12 length length NOUN admet-2089 83 13 of of ADP admet-2089 83 14 14 14 NUM admet-2089 83 15 mer mer NOUN admet-2089 83 16 and and CCONJ admet-2089 83 17 a a DET admet-2089 83 18 representative representative ADJ admet-2089 83 19 set set NOUN admet-2089 83 20 of of ADP admet-2089 83 21 reference reference NOUN admet-2089 83 22 alleles allele NOUN admet-2089 83 23 belonging belong VERB admet-2089 83 24 to to ADP admet-2089 83 25 mhc mhc PROPN admet-2089 83 26 1 1 NUM admet-2089 83 27 consisting consist VERB admet-2089 83 28 of of ADP admet-2089 83 29 human human ADJ admet-2089 83 30 leukocyte leukocyte NOUN admet-2089 83 31 antigens antigen NOUN admet-2089 83 32 ( ( PUNCT admet-2089 83 33 hlaa hlaa NOUN admet-2089 83 34 , , PUNCT admet-2089 83 35 b b PROPN admet-2089 83 36 , , PUNCT admet-2089 83 37 and and CCONJ admet-2089 83 38 c c X admet-2089 83 39 ) ) PUNCT admet-2089 83 40 based base VERB admet-2089 83 41 on on ADP admet-2089 83 42 a a DET admet-2089 83 43 trained train VERB admet-2089 83 44 dataset dataset NOUN admet-2089 83 45 . . PUNCT admet-2089 84 1 on on ADP admet-2089 84 2 the the DET admet-2089 84 3 other other ADJ admet-2089 84 4 hand hand NOUN admet-2089 84 5 , , PUNCT admet-2089 84 6 the the DET admet-2089 84 7 peptide peptide NOUN admet-2089 84 8 binding bind VERB admet-2089 84 9 to to ADP admet-2089 84 10 major major ADJ admet-2089 84 11 histocompatibility histocompatibility NOUN admet-2089 84 12 complex complex ADJ admet-2089 84 13 2 2 NUM admet-2089 84 14 ( ( PUNCT admet-2089 84 15 mhc-2 mhc-2 NOUN admet-2089 84 16 ) ) PUNCT admet-2089 84 17 was be AUX admet-2089 84 18 done do VERB admet-2089 84 19 using use VERB admet-2089 84 20 the the DET admet-2089 84 21 net net ADJ admet-2089 84 22 mhc mhc PROPN admet-2089 84 23 ii ii PROPN admet-2089 84 24 2.3 2.3 NUM admet-2089 84 25 server server NOUN admet-2089 84 26 . . PUNCT admet-2089 85 1 the the DET admet-2089 85 2 epitope epitope NOUN admet-2089 85 3 sequences sequence NOUN admet-2089 85 4 were be AUX admet-2089 85 5 set set VERB admet-2089 85 6 as as ADP admet-2089 85 7 input input NOUN admet-2089 85 8 with with ADP admet-2089 85 9 parameters parameter NOUN admet-2089 85 10 ( ( PUNCT admet-2089 85 11 peptide peptide NOUN admet-2089 85 12 length-14 length-14 PROPN admet-2089 85 13 and and CCONJ admet-2089 85 14 representative representative NOUN admet-2089 85 15 allelesdp allelesdp ADV admet-2089 85 16 , , PUNCT admet-2089 85 17 dq dq PROPN admet-2089 85 18 , , PUNCT admet-2089 85 19 dr dr PROPN admet-2089 85 20 ) ) PUNCT admet-2089 85 21 . . PUNCT admet-2089 86 1 the the DET admet-2089 86 2 binding bind VERB admet-2089 86 3 affinities affinity NOUN admet-2089 86 4 were be AUX admet-2089 86 5 sorted sort VERB admet-2089 86 6 by by ADP admet-2089 86 7 setting set VERB admet-2089 86 8 a a DET admet-2089 86 9 threshold threshold NOUN admet-2089 86 10 for for ADP admet-2089 86 11 strong strong ADJ admet-2089 86 12 binders binder NOUN admet-2089 86 13 at at ADP admet-2089 86 14 2 2 NUM admet-2089 86 15 and and CCONJ admet-2089 86 16 weak weak ADJ admet-2089 86 17 binders binder NOUN admet-2089 86 18 at at ADP admet-2089 86 19 10 10 NUM admet-2089 86 20 . . PUNCT admet-2089 87 1 the the DET admet-2089 87 2 rank rank NOUN admet-2089 87 3 of of ADP admet-2089 87 4 binding bind VERB admet-2089 87 5 affinity affinity NOUN admet-2089 87 6 values value NOUN admet-2089 87 7 < < X admet-2089 87 8 1500 1500 NUM admet-2089 87 9 nm nm PRON admet-2089 87 10 was be AUX admet-2089 87 11 selected select VERB admet-2089 87 12 for for ADP admet-2089 87 13 further further ADJ admet-2089 87 14 analysis analysis NOUN admet-2089 87 15 [ [ X admet-2089 87 16 26 26 NUM admet-2089 87 17 ] ] SYM admet-2089 87 18 . . PUNCT admet-2089 88 1 immune immune ADJ admet-2089 88 2 simulation simulation NOUN admet-2089 88 3 of of ADP admet-2089 88 4 the the DET admet-2089 88 5 protein protein NOUN admet-2089 88 6 the the DET admet-2089 88 7 c c NOUN admet-2089 88 8 - - PUNCT admet-2089 88 9 imm imm VERB admet-2089 88 10 sim sim ADJ admet-2089 88 11 server server NOUN admet-2089 88 12 was be AUX admet-2089 88 13 used use VERB admet-2089 88 14 to to PART admet-2089 88 15 perform perform VERB admet-2089 88 16 the the DET admet-2089 88 17 immune immune ADJ admet-2089 88 18 simulation simulation NOUN admet-2089 88 19 of of ADP admet-2089 88 20 the the DET admet-2089 88 21 thioredoxin thioredoxin PROPN admet-2089 88 22 for for ADP admet-2089 88 23 assessing assess VERB admet-2089 88 24 the the DET admet-2089 88 25 immunogenicity immunogenicity NOUN admet-2089 88 26 and and CCONJ admet-2089 88 27 immune immune ADJ admet-2089 88 28 response response NOUN admet-2089 88 29 attributes attribute NOUN admet-2089 88 30 . . PUNCT admet-2089 89 1 the the DET admet-2089 89 2 immunogenic immunogenic ADJ admet-2089 89 3 profile profile NOUN admet-2089 89 4 was be AUX admet-2089 89 5 simulated simulate VERB admet-2089 89 6 in in ADP admet-2089 89 7 three three NUM admet-2089 89 8 different different ADJ admet-2089 89 9 anatomical anatomical ADJ admet-2089 89 10 regions region NOUN admet-2089 89 11 ( ( PUNCT admet-2089 89 12 bone bone NOUN admet-2089 89 13 marrow marrow NOUN admet-2089 89 14 , , PUNCT admet-2089 89 15 thymus thymus VERB admet-2089 89 16 , , PUNCT admet-2089 89 17 and and CCONJ admet-2089 89 18 lymph lymph NOUN admet-2089 89 19 node node PROPN admet-2089 89 20 ) ) PUNCT admet-2089 89 21 in in ADP admet-2089 89 22 mammals mammal NOUN admet-2089 89 23 . . PUNCT admet-2089 90 1 the the DET admet-2089 90 2 entire entire ADJ admet-2089 90 3 simulation simulation NOUN admet-2089 90 4 ran run VERB admet-2089 90 5 for for ADP admet-2089 90 6 1050 1050 NUM admet-2089 90 7 time time NOUN admet-2089 90 8 steps step NOUN admet-2089 90 9 with with ADP admet-2089 90 10 the the DET admet-2089 90 11 administration administration NOUN admet-2089 90 12 of of ADP admet-2089 90 13 three three NUM admet-2089 90 14 peptide peptide ADJ admet-2089 90 15 injections injection NOUN admet-2089 90 16 at at ADP admet-2089 90 17 an an DET admet-2089 90 18 interval interval NOUN admet-2089 90 19 of of ADP admet-2089 90 20 two two NUM admet-2089 90 21 weeks week NOUN admet-2089 90 22 using use VERB admet-2089 90 23 a a DET admet-2089 90 24 time time NOUN admet-2089 90 25 step step NOUN admet-2089 90 26 set set VERB admet-2089 90 27 at at ADP admet-2089 90 28 1 1 NUM admet-2089 90 29 , , PUNCT admet-2089 90 30 42 42 NUM admet-2089 90 31 , , PUNCT admet-2089 90 32 84 84 NUM admet-2089 90 33 ( ( PUNCT admet-2089 90 34 individual individual ADJ admet-2089 90 35 time time NOUN admet-2089 90 36 step step NOUN admet-2089 90 37 is be AUX admet-2089 90 38 8 8 NUM admet-2089 90 39 hours hour NOUN admet-2089 90 40 and and CCONJ admet-2089 90 41 time time NOUN admet-2089 90 42 step step NOUN admet-2089 90 43 1 1 NUM admet-2089 90 44 is be AUX admet-2089 90 45 injection injection NOUN admet-2089 90 46 at at ADP admet-2089 90 47 time time NOUN admet-2089 90 48 = = SYM admet-2089 90 49 0 0 NUM admet-2089 90 50 ) ) PUNCT admet-2089 90 51 . . PUNCT admet-2089 91 1 the the DET admet-2089 91 2 three three NUM admet-2089 91 3 injections injection NOUN admet-2089 91 4 comprising comprise VERB admet-2089 91 5 1000 1000 NUM admet-2089 91 6 vaccine vaccine NOUN admet-2089 91 7 proteins protein NOUN admet-2089 91 8 were be AUX admet-2089 91 9 used use VERB admet-2089 91 10 . . PUNCT admet-2089 92 1 the the DET admet-2089 92 2 administration administration NOUN admet-2089 92 3 of of ADP admet-2089 92 4 the the DET admet-2089 92 5 vaccine vaccine NOUN admet-2089 92 6 injection injection NOUN admet-2089 92 7 was be AUX admet-2089 92 8 used use VERB admet-2089 92 9 to to PART admet-2089 92 10 calculate calculate VERB admet-2089 92 11 the the DET admet-2089 92 12 antibody antibody NOUN admet-2089 92 13 and and CCONJ admet-2089 92 14 cytokine cytokine VERB admet-2089 92 15 production production NOUN admet-2089 92 16 immune immune ADJ admet-2089 92 17 responses response NOUN admet-2089 92 18 of of ADP admet-2089 92 19 helper helper NOUN admet-2089 92 20 cells cell NOUN admet-2089 92 21 , , PUNCT admet-2089 92 22 b b X admet-2089 92 23 - - PUNCT admet-2089 92 24 cells cell NOUN admet-2089 92 25 , , PUNCT admet-2089 92 26 natural natural ADJ admet-2089 92 27 killer killer NOUN admet-2089 92 28 cells cell NOUN admet-2089 92 29 and and CCONJ admet-2089 92 30 antigen antigen NOUN admet-2089 92 31 - - PUNCT admet-2089 92 32 presenting present VERB admet-2089 92 33 cells cell NOUN admet-2089 92 34 [ [ X admet-2089 92 35 27 27 NUM admet-2089 92 36 ] ] PUNCT admet-2089 92 37 . . PUNCT admet-2089 93 1 statistics statistic NOUN admet-2089 93 2 all all DET admet-2089 93 3 the the DET admet-2089 93 4 results result NOUN admet-2089 93 5 were be AUX admet-2089 93 6 done do VERB admet-2089 93 7 in in ADP admet-2089 93 8 triplicates triplicate NOUN admet-2089 93 9 and and CCONJ admet-2089 93 10 are be AUX admet-2089 93 11 expressed express VERB admet-2089 93 12 as as ADP admet-2089 93 13 mean mean NOUN admet-2089 93 14 ± ± NUM admet-2089 93 15 sd sd NOUN admet-2089 93 16 . . PUNCT admet-2089 94 1 analysis analysis NOUN admet-2089 94 2 of of ADP admet-2089 94 3 variance variance NOUN admet-2089 94 4 ( ( PUNCT admet-2089 94 5 one one NUM admet-2089 94 6 - - PUNCT admet-2089 94 7 way way NOUN admet-2089 94 8 anova anova PROPN admet-2089 94 9 ) ) PUNCT admet-2089 94 10 of of ADP admet-2089 94 11 data datum NOUN admet-2089 94 12 was be AUX admet-2089 94 13 performed perform VERB admet-2089 94 14 for for ADP admet-2089 94 15 statistical statistical ADJ admet-2089 94 16 significance significance NOUN admet-2089 94 17 ( ( PUNCT admet-2089 94 18 p p X admet-2089 94 19 < < X admet-2089 94 20 0.05 0.05 NUM admet-2089 94 21 ) ) PUNCT admet-2089 94 22 , , PUNCT admet-2089 94 23 followed follow VERB admet-2089 94 24 by by ADP admet-2089 94 25 tukey tukey PROPN admet-2089 94 26 ’s ’s PART admet-2089 94 27 test test NOUN admet-2089 94 28 for for ADP admet-2089 94 29 individual individual ADJ admet-2089 94 30 column column NOUN admet-2089 94 31 comparison comparison NOUN admet-2089 94 32 . . PUNCT admet-2089 95 1 in in ADP admet-2089 95 2 all all DET admet-2089 95 3 circumstances circumstance NOUN admet-2089 95 4 , , PUNCT admet-2089 95 5 statistical statistical ADJ admet-2089 95 6 analysis analysis NOUN admet-2089 95 7 was be AUX admet-2089 95 8 conducted conduct VERB admet-2089 95 9 using use VERB admet-2089 95 10 the the DET admet-2089 95 11 graphpad graphpad NOUN admet-2089 95 12 prism prism NOUN admet-2089 95 13 software software NOUN admet-2089 95 14 version version NOUN admet-2089 95 15 5 5 NUM admet-2089 95 16 . . PUNCT admet-2089 95 17 results result NOUN admet-2089 95 18 and and CCONJ admet-2089 95 19 discussion discussion NOUN admet-2089 95 20 expression expression NOUN admet-2089 95 21 and and CCONJ admet-2089 95 22 purification purification NOUN admet-2089 95 23 of of ADP admet-2089 95 24 filarial filarial ADJ admet-2089 95 25 antigen antigen NOUN admet-2089 95 26 the the DET admet-2089 95 27 recombinant recombinant ADJ admet-2089 95 28 filarial filarial ADJ admet-2089 95 29 antigen antigen NOUN admet-2089 95 30 trx trx NOUN admet-2089 95 31 without without ADP admet-2089 95 32 histidine histidine ADJ admet-2089 95 33 tag tag NOUN admet-2089 95 34 is be AUX admet-2089 95 35 expressed express VERB admet-2089 95 36 as as ADP admet-2089 95 37 20 20 NUM admet-2089 95 38 kda kda NOUN admet-2089 95 39 protein protein NOUN admet-2089 95 40 and and CCONJ admet-2089 95 41 purified purified ADJ admet-2089 95 42 using use VERB admet-2089 95 43 ion ion NOUN admet-2089 95 44 - - PUNCT admet-2089 95 45 exchange exchange NOUN admet-2089 95 46 chromatography chromatography NOUN admet-2089 95 47 . . PUNCT admet-2089 96 1 synthesis synthesis NOUN admet-2089 96 2 and and CCONJ admet-2089 96 3 characterization characterization NOUN admet-2089 96 4 of of ADP admet-2089 96 5 nano nano NOUN admet-2089 96 6 - - PUNCT admet-2089 96 7 liposome liposome NOUN admet-2089 96 8 liposomes liposome NOUN admet-2089 96 9 were be AUX admet-2089 96 10 prepared prepare VERB admet-2089 96 11 by by ADP admet-2089 96 12 thin thin ADJ admet-2089 96 13 film film NOUN admet-2089 96 14 hydration hydration NOUN admet-2089 96 15 technique technique NOUN admet-2089 96 16 . . PUNCT admet-2089 97 1 the the DET admet-2089 97 2 thin thin ADJ admet-2089 97 3 film film NOUN admet-2089 97 4 , , PUNCT admet-2089 97 5 when when SCONJ admet-2089 97 6 hydrated hydrated ADJ admet-2089 97 7 with with ADP admet-2089 97 8 an an DET admet-2089 97 9 aqueous aqueous ADJ admet-2089 97 10 buffer buffer NOUN admet-2089 97 11 , , PUNCT admet-2089 97 12 spontaneously spontaneously ADV admet-2089 97 13 swells swell VERB admet-2089 97 14 and and CCONJ admet-2089 97 15 folds fold NOUN admet-2089 97 16 to to PART admet-2089 97 17 form form VERB admet-2089 97 18 liposomes liposome NOUN admet-2089 97 19 . . PUNCT admet-2089 98 1 as as SCONJ admet-2089 98 2 this this DET admet-2089 98 3 technique technique NOUN admet-2089 98 4 forms form VERB admet-2089 98 5 heterogeneous heterogeneous ADJ admet-2089 98 6 - - PUNCT admet-2089 98 7 sized sized ADJ admet-2089 98 8 liposomes liposome NOUN admet-2089 98 9 with with ADP admet-2089 98 10 micron micron NOUN admet-2089 98 11 range range NOUN admet-2089 98 12 diameter diameter NOUN admet-2089 98 13 , , PUNCT admet-2089 98 14 the the DET admet-2089 98 15 size size NOUN admet-2089 98 16 is be AUX admet-2089 98 17 further far ADV admet-2089 98 18 reduced reduce VERB admet-2089 98 19 by by ADP admet-2089 98 20 various various ADJ admet-2089 98 21 sonication sonication NOUN admet-2089 98 22 ( ( PUNCT admet-2089 98 23 5 5 NUM admet-2089 98 24 , , PUNCT admet-2089 98 25 10 10 NUM admet-2089 98 26 , , PUNCT admet-2089 98 27 15 15 NUM admet-2089 98 28 , , PUNCT admet-2089 98 29 20 20 NUM admet-2089 98 30 , , PUNCT admet-2089 98 31 25 25 NUM admet-2089 98 32 , , PUNCT admet-2089 98 33 and and CCONJ admet-2089 98 34 30 30 NUM admet-2089 98 35 ) ) PUNCT admet-2089 98 36 cycles cycle NOUN admet-2089 98 37 . . PUNCT admet-2089 99 1 the the DET admet-2089 99 2 size size NOUN admet-2089 99 3 was be AUX admet-2089 99 4 determined determine VERB admet-2089 99 5 using use VERB admet-2089 99 6 dls dls PROPN admet-2089 99 7 . . PUNCT admet-2089 100 1 though though SCONJ admet-2089 100 2 sonication sonication NOUN admet-2089 100 3 led lead VERB admet-2089 100 4 to to ADP admet-2089 100 5 the the DET admet-2089 100 6 formation formation NOUN admet-2089 100 7 of of ADP admet-2089 100 8 nano nano NOUN admet-2089 100 9 - - PUNCT admet-2089 100 10 scaled scale VERB admet-2089 100 11 liposomes liposome NOUN admet-2089 100 12 for for ADP admet-2089 100 13 the the DET admet-2089 100 14 various various ADJ admet-2089 100 15 cycles cycle NOUN admet-2089 100 16 ( ( PUNCT admet-2089 100 17 449.79 449.79 NUM admet-2089 100 18 ± ± NUM admet-2089 100 19 13.47 13.47 NUM admet-2089 100 20 , , PUNCT admet-2089 100 21 371 371 NUM admet-2089 100 22 ± ± NUM admet-2089 100 23 64.89 64.89 NUM admet-2089 100 24 , , PUNCT admet-2089 100 25 302.87 302.87 NUM admet-2089 100 26 ± ± NUM admet-2089 100 27 39.56 39.56 NUM admet-2089 100 28 , , PUNCT admet-2089 100 29 255.09 255.09 NUM admet-2089 100 30 ± ± NUM admet-2089 100 31 5.65 5.65 NUM admet-2089 100 32 , , PUNCT admet-2089 100 33 209.86 209.86 NUM admet-2089 100 34 ± ± NUM admet-2089 100 35 9.79 9.79 NUM admet-2089 100 36 and and CCONJ admet-2089 100 37 174.16 174.16 NUM admet-2089 100 38 ± ± NUM admet-2089 100 39 9.02 9.02 NUM admet-2089 100 40 nm nm NOUN admet-2089 100 41 ) ) PUNCT admet-2089 100 42 , , PUNCT admet-2089 100 43 uniform uniform ADJ admet-2089 100 44 distribution distribution NOUN admet-2089 100 45 was be AUX admet-2089 100 46 obtained obtain VERB admet-2089 100 47 for for ADP admet-2089 100 48 25 25 NUM admet-2089 100 49 cycles cycle NOUN admet-2089 100 50 of of ADP admet-2089 100 51 sonication sonication NOUN admet-2089 100 52 as as SCONJ admet-2089 100 53 shown show VERB admet-2089 100 54 in in ADP admet-2089 100 55 the the DET admet-2089 100 56 figures figure NOUN admet-2089 100 57 1a 1a PROPN admet-2089 100 58 and and CCONJ admet-2089 100 59 b. b. PROPN admet-2089 100 60 as as ADP admet-2089 100 61 evident evident ADJ admet-2089 100 62 from from ADP admet-2089 100 63 figure figure NOUN admet-2089 100 64 1(a 1(a NUM admet-2089 100 65 ) ) PUNCT admet-2089 100 66 , , PUNCT admet-2089 100 67 sonication sonication NOUN admet-2089 100 68 plays play VERB admet-2089 100 69 a a DET admet-2089 100 70 crucial crucial ADJ admet-2089 100 71 role role NOUN admet-2089 100 72 in in ADP admet-2089 100 73 the the DET admet-2089 100 74 size size NOUN admet-2089 100 75 and and CCONJ admet-2089 100 76 distribution distribution NOUN admet-2089 100 77 of of ADP admet-2089 100 78 the the DET admet-2089 100 79 vesicles vesicle NOUN admet-2089 100 80 . . PUNCT admet-2089 101 1 earlier early ADJ admet-2089 101 2 studies study NOUN admet-2089 101 3 have have AUX admet-2089 101 4 suggested suggest VERB admet-2089 101 5 that that SCONJ admet-2089 101 6 the the DET admet-2089 101 7 higher high ADJ admet-2089 101 8 energy energy NOUN admet-2089 101 9 input input NOUN admet-2089 101 10 results result NOUN admet-2089 101 11 in in ADP admet-2089 101 12 control control NOUN admet-2089 101 13 of of ADP admet-2089 101 14 final final ADJ admet-2089 101 15 vesicles vesicle NOUN admet-2089 101 16 and and CCONJ admet-2089 101 17 homogeneity homogeneity NOUN admet-2089 101 18 via via ADP admet-2089 101 19 mechanical mechanical ADJ admet-2089 101 20 collision collision NOUN admet-2089 102 1 [ [ X admet-2089 102 2 28 28 NUM admet-2089 102 3 - - SYM admet-2089 102 4 30 30 NUM admet-2089 102 5 ] ] PUNCT admet-2089 102 6 . . PUNCT admet-2089 103 1 this this DET admet-2089 103 2 collision collision NOUN admet-2089 103 3 causes cause VERB admet-2089 103 4 breaking break VERB admet-2089 103 5 and and CCONJ admet-2089 103 6 making make VERB admet-2089 103 7 processes process NOUN admet-2089 103 8 , , PUNCT admet-2089 103 9 leading lead VERB admet-2089 103 10 to to ADP admet-2089 103 11 smaller small ADJ admet-2089 103 12 size size NOUN admet-2089 103 13 . . PUNCT admet-2089 104 1 and and CCONJ admet-2089 104 2 these these DET admet-2089 104 3 findings finding NOUN admet-2089 104 4 correlate correlate VERB admet-2089 104 5 with with ADP admet-2089 104 6 our our PRON admet-2089 104 7 present present ADJ admet-2089 104 8 study study NOUN admet-2089 104 9 . . PUNCT admet-2089 105 1 thus thus ADV admet-2089 105 2 , , PUNCT admet-2089 105 3 we we PRON admet-2089 105 4 infer infer VERB admet-2089 105 5 that that SCONJ admet-2089 105 6 the the DET admet-2089 105 7 optimised optimise VERB admet-2089 105 8 sonication sonication NOUN admet-2089 105 9 cycle cycle NOUN admet-2089 105 10 of of ADP admet-2089 105 11 25 25 NUM admet-2089 105 12 led lead VERB admet-2089 105 13 to to ADP admet-2089 105 14 the the DET admet-2089 105 15 formation formation NOUN admet-2089 105 16 of of ADP admet-2089 105 17 narrow narrow ADJ admet-2089 105 18 polydispersity polydispersity NOUN admet-2089 105 19 nano nano NOUN admet-2089 105 20 - - PUNCT admet-2089 105 21 liposomes liposome NOUN admet-2089 105 22 , , PUNCT admet-2089 105 23 which which PRON admet-2089 105 24 were be AUX admet-2089 105 25 taken take VERB admet-2089 105 26 for for ADP admet-2089 105 27 further further ADJ admet-2089 105 28 characterization characterization NOUN admet-2089 105 29 using use VERB admet-2089 105 30 tem tem PROPN admet-2089 105 31 . . PUNCT admet-2089 106 1 the the DET admet-2089 106 2 tem tem PROPN admet-2089 106 3 image image NOUN admet-2089 106 4 ( ( PUNCT admet-2089 106 5 figure figure NOUN admet-2089 106 6 1c 1c NOUN admet-2089 106 7 ) ) PUNCT admet-2089 106 8 further far ADV admet-2089 106 9 confirms confirm VERB admet-2089 106 10 the the DET admet-2089 106 11 size size NOUN admet-2089 106 12 of of ADP admet-2089 106 13 nano nano NOUN admet-2089 106 14 - - PUNCT admet-2089 106 15 liposomes liposome NOUN admet-2089 106 16 . . PUNCT admet-2089 107 1 the the DET admet-2089 107 2 image image NOUN admet-2089 107 3 also also ADV admet-2089 107 4 revealed reveal VERB admet-2089 107 5 the the DET admet-2089 107 6 spherical spherical ADJ admet-2089 107 7 morphology morphology NOUN admet-2089 107 8 and and CCONJ admet-2089 107 9 narrow narrow ADJ admet-2089 107 10 size size NOUN admet-2089 107 11 of of ADP admet-2089 107 12 the the DET admet-2089 107 13 optimised optimise VERB admet-2089 107 14 nano nano NOUN admet-2089 107 15 - - PUNCT admet-2089 107 16 liposomes liposome NOUN admet-2089 107 17 . . PUNCT admet-2089 108 1 https://paperpile.com/c/plxgz5/pik2 https://paperpile.com/c/plxgz5/pik2 NUM admet-2089 108 2 https://paperpile.com/c/plxgz5/njp7 https://paperpile.com/c/plxgz5/njp7 PROPN admet-2089 108 3 https://paperpile.com/c/plxgz5/yygnz https://paperpile.com/c/plxgz5/yygnz PROPN admet-2089 108 4 https://paperpile.com/c/plxgz5/8py2j+diyvn+zgfmz https://paperpile.com/c/plxgz5/8py2j+diyvn+zgfmz PROPN admet-2089 108 5 admet admet PROPN admet-2089 108 6 & & CCONJ admet-2089 108 7 dmpk dmpk PROPN admet-2089 108 8 12(2 12(2 NUM admet-2089 108 9 ) ) PUNCT admet-2089 108 10 ( ( PUNCT admet-2089 108 11 2024 2024 NUM admet-2089 108 12 ) ) PUNCT admet-2089 108 13 379 379 NUM admet-2089 108 14 - - SYM admet-2089 108 15 389 389 NUM admet-2089 108 16 encapsulation encapsulation NOUN admet-2089 108 17 of of ADP admet-2089 108 18 brugia brugia ADJ admet-2089 108 19 malayi malayi VERB admet-2089 108 20 thioredoxin thioredoxin PROPN admet-2089 108 21 in in ADP admet-2089 108 22 nano nano NOUN admet-2089 108 23 - - PUNCT admet-2089 108 24 liposomes liposome NOUN admet-2089 108 25 doi doi NOUN admet-2089 108 26 : : PUNCT admet-2089 108 27 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 108 28 383 383 NUM admet-2089 108 29 figure figure NOUN admet-2089 108 30 1 1 NUM admet-2089 108 31 . . PUNCT admet-2089 109 1 ( ( PUNCT admet-2089 109 2 a a X admet-2089 109 3 ) ) PUNCT admet-2089 109 4 effect effect NOUN admet-2089 109 5 of of ADP admet-2089 109 6 sonication sonication NOUN admet-2089 109 7 on on ADP admet-2089 109 8 uniform uniform ADJ admet-2089 109 9 distribution distribution NOUN admet-2089 109 10 of of ADP admet-2089 109 11 liposomes liposome NOUN admet-2089 109 12 . . PUNCT admet-2089 110 1 the the DET admet-2089 110 2 dls dls PROPN admet-2089 110 3 uniformity uniformity NOUN admet-2089 110 4 study study NOUN admet-2089 110 5 shows show VERB admet-2089 110 6 that that SCONJ admet-2089 110 7 the the DET admet-2089 110 8 25th 25th ADJ admet-2089 110 9 cycle cycle NOUN admet-2089 110 10 produced produce VERB admet-2089 110 11 evenly evenly ADV admet-2089 110 12 distributed distribute VERB admet-2089 110 13 liposomes liposome NOUN admet-2089 110 14 . . PUNCT admet-2089 111 1 ( ( PUNCT admet-2089 111 2 b b X admet-2089 111 3 ) ) PUNCT admet-2089 111 4 the the DET admet-2089 111 5 increase increase NOUN admet-2089 111 6 in in ADP admet-2089 111 7 the the DET admet-2089 111 8 sonication sonication NOUN admet-2089 111 9 cycle cycle NOUN admet-2089 111 10 reduced reduce VERB admet-2089 111 11 the the DET admet-2089 111 12 size size NOUN admet-2089 111 13 of of ADP admet-2089 111 14 the the DET admet-2089 111 15 liposomes liposome NOUN admet-2089 111 16 . . PUNCT admet-2089 112 1 ( ( PUNCT admet-2089 112 2 c c X admet-2089 112 3 ) ) PUNCT admet-2089 112 4 tem tem NOUN admet-2089 112 5 images image NOUN admet-2089 112 6 of of ADP admet-2089 112 7 liposomes liposome NOUN admet-2089 112 8 were be AUX admet-2089 112 9 produced produce VERB admet-2089 112 10 with with ADP admet-2089 112 11 epc epc PROPN admet-2089 112 12 at at ADP admet-2089 112 13 25 25 NUM admet-2089 112 14 cycles cycle NOUN admet-2089 112 15 of of ADP admet-2089 112 16 sonication sonication NOUN admet-2089 112 17 . . PUNCT admet-2089 113 1 filarial filarial ADJ admet-2089 113 2 antigen antigen ADJ admet-2089 113 3 encapsulation encapsulation NOUN admet-2089 113 4 the the DET admet-2089 113 5 epc epc PROPN admet-2089 113 6 and and CCONJ admet-2089 113 7 cholesterol cholesterol NOUN admet-2089 113 8 in in ADP admet-2089 113 9 ratios ratio NOUN admet-2089 113 10 ( ( PUNCT admet-2089 113 11 10:0 10:0 PROPN admet-2089 113 12 , , PUNCT admet-2089 113 13 9:1 9:1 NUM admet-2089 113 14 , , PUNCT admet-2089 113 15 8:2 8:2 NUM admet-2089 113 16 , , PUNCT admet-2089 113 17 7:3 7:3 NUM admet-2089 113 18 , , PUNCT admet-2089 113 19 6:4 6:4 NUM admet-2089 113 20 , , PUNCT admet-2089 113 21 5:5 5:5 NUM admet-2089 113 22 ) ) PUNCT admet-2089 113 23 with with ADP admet-2089 113 24 a a DET admet-2089 113 25 total total ADJ admet-2089 113 26 lipid lipid NOUN admet-2089 113 27 quantity quantity NOUN admet-2089 113 28 of of ADP admet-2089 113 29 10 10 NUM admet-2089 113 30 mg mg NOUN admet-2089 113 31 was be AUX admet-2089 113 32 used use VERB admet-2089 113 33 to to PART admet-2089 113 34 encapsulate encapsulate VERB admet-2089 113 35 trx trx NOUN admet-2089 113 36 in in ADP admet-2089 113 37 various various ADJ admet-2089 113 38 phospholipid phospholipid NOUN admet-2089 113 39 to to ADP admet-2089 113 40 antigen antigen ADJ admet-2089 113 41 ratio ratio NOUN admet-2089 113 42 ( ( PUNCT admet-2089 113 43 10:1 10:1 NUM admet-2089 113 44 , , PUNCT admet-2089 113 45 10:2 10:2 NUM admet-2089 113 46 , , PUNCT admet-2089 113 47 10:3 10:3 NUM admet-2089 113 48 ) ) PUNCT admet-2089 113 49 . . PUNCT admet-2089 114 1 the the DET admet-2089 114 2 liposomal liposomal ADJ admet-2089 114 3 composition composition NOUN admet-2089 114 4 plays play VERB admet-2089 114 5 a a DET admet-2089 114 6 significant significant ADJ admet-2089 114 7 role role NOUN admet-2089 114 8 in in ADP admet-2089 114 9 its its PRON admet-2089 114 10 antigen antigen NOUN admet-2089 114 11 loading loading NOUN admet-2089 114 12 and and CCONJ admet-2089 114 13 stability stability NOUN admet-2089 114 14 . . PUNCT admet-2089 115 1 as as SCONJ admet-2089 115 2 shown show VERB admet-2089 115 3 in in ADP admet-2089 115 4 figure figure NOUN admet-2089 115 5 2a 2a NUM admet-2089 115 6 , , PUNCT admet-2089 115 7 the the DET admet-2089 115 8 encapsulation encapsulation NOUN admet-2089 115 9 efficiency efficiency NOUN admet-2089 115 10 of of ADP admet-2089 115 11 trx trx NOUN admet-2089 115 12 was be AUX admet-2089 115 13 influenced influence VERB admet-2089 115 14 by by ADP admet-2089 115 15 the the DET admet-2089 115 16 presence presence NOUN admet-2089 115 17 of of ADP admet-2089 115 18 cholesterol cholesterol NOUN admet-2089 115 19 . . PUNCT admet-2089 116 1 encapsulation encapsulation NOUN admet-2089 116 2 efficiency efficiency NOUN admet-2089 116 3 increased increase VERB admet-2089 116 4 with with ADP admet-2089 116 5 increase increase NOUN admet-2089 116 6 in in ADP admet-2089 116 7 cholesterol cholesterol NOUN admet-2089 116 8 and and CCONJ admet-2089 116 9 antigen antigen ADJ admet-2089 116 10 weight weight NOUN admet-2089 116 11 ratio ratio NOUN admet-2089 116 12 . . PUNCT admet-2089 117 1 increase increase NOUN admet-2089 117 2 in in ADP admet-2089 117 3 encapsulation encapsulation NOUN admet-2089 117 4 was be AUX admet-2089 117 5 observed observe VERB admet-2089 117 6 till till SCONJ admet-2089 117 7 7:3 7:3 NUM admet-2089 117 8 ( ( PUNCT admet-2089 117 9 phospholipid phospholipid NOUN admet-2089 117 10 : : PUNCT admet-2089 117 11 cholesterol cholesterol NOUN admet-2089 117 12 ) ) PUNCT admet-2089 117 13 weight weight NOUN admet-2089 117 14 ratio ratio NOUN admet-2089 117 15 and and CCONJ admet-2089 117 16 10:03 10:03 NUM admet-2089 117 17 ( ( PUNCT admet-2089 117 18 phospholipid phospholipid NOUN admet-2089 117 19 : : PUNCT admet-2089 117 20 trx trx NOUN admet-2089 117 21 ) ) PUNCT admet-2089 117 22 weight weight NOUN admet-2089 117 23 ratio ratio NOUN admet-2089 117 24 . . PUNCT admet-2089 118 1 figure figure NOUN admet-2089 118 2 2 2 NUM admet-2089 118 3 . . PUNCT admet-2089 119 1 ( ( PUNCT admet-2089 119 2 a a X admet-2089 119 3 ) ) PUNCT admet-2089 119 4 effect effect NOUN admet-2089 119 5 of of ADP admet-2089 119 6 cholesterol cholesterol NOUN admet-2089 119 7 and and CCONJ admet-2089 119 8 phopholipid phopholipid NOUN admet-2089 119 9 : : PUNCT admet-2089 119 10 trx trx NOUN admet-2089 119 11 weight weight NOUN admet-2089 119 12 ratio ratio NOUN admet-2089 119 13 on on ADP admet-2089 119 14 encapsulation encapsulation NOUN admet-2089 119 15 efficiency efficiency NOUN admet-2089 119 16 . . PUNCT admet-2089 120 1 ( ( PUNCT admet-2089 120 2 b b X admet-2089 120 3 ) ) PUNCT admet-2089 120 4 trx trx NOUN admet-2089 120 5 - - PUNCT admet-2089 120 6 release release NOUN admet-2089 120 7 kinetics kinetic NOUN admet-2089 120 8 from from ADP admet-2089 120 9 nano nano NOUN admet-2089 120 10 - - PUNCT admet-2089 120 11 liposomes liposome NOUN admet-2089 120 12 . . PUNCT admet-2089 121 1 the the DET admet-2089 121 2 release release NOUN admet-2089 121 3 of of ADP admet-2089 121 4 antigen antigen NOUN admet-2089 121 5 from from ADP admet-2089 121 6 different different ADJ admet-2089 121 7 weight weight NOUN admet-2089 121 8 ratios ratio NOUN admet-2089 121 9 of of ADP admet-2089 121 10 epc epc PROPN admet-2089 121 11 : : PUNCT admet-2089 121 12 cholesterol cholesterol NOUN admet-2089 121 13 ( ( PUNCT admet-2089 121 14 8:2 8:2 NUM admet-2089 121 15 , , PUNCT admet-2089 121 16 7:3 7:3 NUM admet-2089 121 17 , , PUNCT admet-2089 121 18 6:4 6:4 NUM admet-2089 121 19 ) ) PUNCT admet-2089 121 20 showed show VERB admet-2089 121 21 comparatively comparatively ADV admet-2089 121 22 stable stable ADJ admet-2089 121 23 release release NOUN admet-2089 121 24 in in ADP admet-2089 121 25 7:3 7:3 NUM admet-2089 121 26 compositions composition NOUN admet-2089 121 27 . . PUNCT admet-2089 122 1 the the DET admet-2089 122 2 liposome liposome NOUN admet-2089 122 3 consisting consist VERB admet-2089 122 4 of of ADP admet-2089 122 5 cholesterol cholesterol NOUN admet-2089 122 6 ( ( PUNCT admet-2089 122 7 7:3 7:3 NOUN admet-2089 122 8 ) ) PUNCT admet-2089 122 9 showed show VERB admet-2089 122 10 significantly significantly ADV admet-2089 122 11 high high ADJ admet-2089 122 12 encapsulation encapsulation NOUN admet-2089 122 13 ( ( PUNCT admet-2089 122 14 p>0.05 p>0.05 NOUN admet-2089 122 15 ) ) PUNCT admet-2089 122 16 when when SCONJ admet-2089 122 17 compared compare VERB admet-2089 122 18 to to ADP admet-2089 122 19 epc epc PROPN admet-2089 122 20 with with ADP admet-2089 122 21 no no DET admet-2089 122 22 cholesterol cholesterol NOUN admet-2089 122 23 . . PUNCT admet-2089 123 1 further further ADJ admet-2089 123 2 increase increase NOUN admet-2089 123 3 of of ADP admet-2089 123 4 cholesterol cholesterol NOUN admet-2089 123 5 diminished diminish VERB admet-2089 123 6 the the DET admet-2089 123 7 antigen antigen ADJ admet-2089 123 8 loading loading NOUN admet-2089 123 9 efficiency efficiency NOUN admet-2089 123 10 of of ADP admet-2089 123 11 liposomes liposome NOUN admet-2089 123 12 . . PUNCT admet-2089 124 1 the the DET admet-2089 124 2 lipid lipid NOUN admet-2089 124 3 to to ADP admet-2089 124 4 trx trx PROPN admet-2089 124 5 10:3 10:3 NUM admet-2089 124 6 ratio ratio NOUN admet-2089 124 7 had have VERB admet-2089 124 8 high high ADJ admet-2089 124 9 encapsulation encapsulation NOUN admet-2089 124 10 efficiency efficiency NOUN admet-2089 124 11 . . PUNCT admet-2089 125 1 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 PROPN admet-2089 125 2 m. m. PROPN admet-2089 125 3 balasubramaniyan balasubramaniyan PROPN admet-2089 125 4 et et PROPN admet-2089 125 5 al al PROPN admet-2089 125 6 . . PROPN admet-2089 125 7 admet admet PROPN admet-2089 125 8 & & CCONJ admet-2089 125 9 dmpk dmpk PROPN admet-2089 125 10 12(2 12(2 NUM admet-2089 125 11 ) ) PUNCT admet-2089 125 12 ( ( PUNCT admet-2089 125 13 2024 2024 NUM admet-2089 125 14 ) ) PUNCT admet-2089 125 15 379 379 NUM admet-2089 125 16 - - SYM admet-2089 125 17 389 389 NUM admet-2089 125 18 384 384 NUM admet-2089 125 19 enhancement enhancement NOUN admet-2089 125 20 of of ADP admet-2089 125 21 cholesterol cholesterol NOUN admet-2089 125 22 interferes interfere VERB admet-2089 125 23 with with ADP admet-2089 125 24 the the DET admet-2089 125 25 tight tight ADJ admet-2089 125 26 packing packing NOUN admet-2089 125 27 of of ADP admet-2089 125 28 lipids lipid NOUN admet-2089 125 29 and and CCONJ admet-2089 125 30 induces induce VERB admet-2089 125 31 membrane membrane ADJ admet-2089 125 32 fluidity fluidity NOUN admet-2089 125 33 . . PUNCT admet-2089 126 1 this this DET admet-2089 126 2 results result VERB admet-2089 126 3 in in ADP admet-2089 126 4 better well ADJ admet-2089 126 5 distribution distribution NOUN admet-2089 126 6 of of ADP admet-2089 126 7 the the DET admet-2089 126 8 aqueous aqueous ADJ admet-2089 126 9 phase phase NOUN admet-2089 126 10 and and CCONJ admet-2089 126 11 , , PUNCT admet-2089 126 12 thereby thereby ADV admet-2089 126 13 , , PUNCT admet-2089 126 14 amplifying amplifying ADJ admet-2089 126 15 protein protein NOUN admet-2089 126 16 encapsulation encapsulation NOUN admet-2089 126 17 . . PUNCT admet-2089 127 1 earlier early ADJ admet-2089 127 2 study study NOUN admet-2089 127 3 has have AUX admet-2089 127 4 also also ADV admet-2089 127 5 reported report VERB admet-2089 127 6 the the DET admet-2089 127 7 role role NOUN admet-2089 127 8 of of ADP admet-2089 127 9 cholesterol cholesterol NOUN admet-2089 127 10 in in ADP admet-2089 127 11 incrementing incremente VERB admet-2089 127 12 encapsulation encapsulation NOUN admet-2089 127 13 [ [ X admet-2089 127 14 31 31 NUM admet-2089 127 15 ] ] PUNCT admet-2089 127 16 . . PUNCT admet-2089 128 1 the the DET admet-2089 128 2 role role NOUN admet-2089 128 3 of of ADP admet-2089 128 4 electrostatic electrostatic ADJ admet-2089 128 5 interaction interaction NOUN admet-2089 128 6 between between ADP admet-2089 128 7 the the DET admet-2089 128 8 bovine bovine NOUN admet-2089 128 9 serum serum NOUN admet-2089 128 10 albumin albumin PROPN admet-2089 128 11 and and CCONJ admet-2089 128 12 lipid lipid NOUN admet-2089 128 13 surfaces surface NOUN admet-2089 128 14 in in ADP admet-2089 128 15 increasing increase VERB admet-2089 128 16 the the DET admet-2089 128 17 encapsulation encapsulation NOUN admet-2089 128 18 of of ADP admet-2089 128 19 the the DET admet-2089 128 20 former former NOUN admet-2089 128 21 has have AUX admet-2089 128 22 also also ADV admet-2089 128 23 been be AUX admet-2089 128 24 reported report VERB admet-2089 128 25 [ [ X admet-2089 128 26 32 32 NUM admet-2089 128 27 ] ] PUNCT admet-2089 128 28 . . PUNCT admet-2089 129 1 we we PRON admet-2089 129 2 , , PUNCT admet-2089 129 3 therefore therefore ADV admet-2089 129 4 , , PUNCT admet-2089 129 5 infer infer VERB admet-2089 129 6 that that SCONJ admet-2089 129 7 along along ADP admet-2089 129 8 with with ADP admet-2089 129 9 entrapment entrapment NOUN admet-2089 129 10 in in ADP admet-2089 129 11 the the DET admet-2089 129 12 hydrophilic hydrophilic ADJ admet-2089 129 13 compartment compartment NOUN admet-2089 129 14 , , PUNCT admet-2089 129 15 there there PRON admet-2089 129 16 is be VERB admet-2089 129 17 an an DET admet-2089 129 18 electrostatic electrostatic ADJ admet-2089 129 19 interaction interaction NOUN admet-2089 129 20 between between ADP admet-2089 129 21 the the DET admet-2089 129 22 negatively negatively ADV admet-2089 129 23 charged charge VERB admet-2089 129 24 trx trx NOUN admet-2089 129 25 at at ADP admet-2089 129 26 neutral neutral ADJ admet-2089 129 27 ph ph NOUN admet-2089 129 28 with with ADP admet-2089 129 29 the the DET admet-2089 129 30 positively positively ADV admet-2089 129 31 charged charge VERB admet-2089 129 32 amine amine NOUN admet-2089 129 33 in in ADP admet-2089 129 34 the the DET admet-2089 129 35 bilayer bilayer NOUN admet-2089 129 36 composition composition NOUN admet-2089 129 37 of of ADP admet-2089 129 38 liposome liposome NOUN admet-2089 129 39 , , PUNCT admet-2089 129 40 thereby thereby ADV admet-2089 129 41 resulting result VERB admet-2089 129 42 in in ADP admet-2089 129 43 significantly significantly ADV admet-2089 129 44 higher high ADJ admet-2089 129 45 encapsulation encapsulation NOUN admet-2089 129 46 efficiency efficiency NOUN admet-2089 129 47 in in ADP admet-2089 129 48 a a DET admet-2089 129 49 10:3 10:3 NUM admet-2089 129 50 ratio ratio NOUN admet-2089 129 51 . . PUNCT admet-2089 130 1 thus thus ADV admet-2089 130 2 , , PUNCT admet-2089 130 3 we we PRON admet-2089 130 4 validate validate VERB admet-2089 130 5 the the DET admet-2089 130 6 10:03 10:03 NUM admet-2089 130 7 ratio ratio NOUN admet-2089 130 8 of of ADP admet-2089 130 9 phospholipid phospholipid NOUN admet-2089 130 10 : : PUNCT admet-2089 130 11 trx trx NOUN admet-2089 130 12 as as ADP admet-2089 130 13 an an DET admet-2089 130 14 optimised optimise VERB admet-2089 130 15 proportion proportion NOUN admet-2089 130 16 for for ADP admet-2089 130 17 further further ADJ admet-2089 130 18 application application NOUN admet-2089 130 19 of of ADP admet-2089 130 20 nano nano NOUN admet-2089 130 21 - - PUNCT admet-2089 130 22 liposomes liposome NOUN admet-2089 130 23 as as ADP admet-2089 130 24 vaccine vaccine NOUN admet-2089 130 25 carriers carrier NOUN admet-2089 130 26 . . PUNCT admet-2089 131 1 release release NOUN admet-2089 131 2 kinetics kinetic VERB admet-2089 131 3 the the DET admet-2089 131 4 optimised optimise VERB admet-2089 131 5 lipid lipid NOUN admet-2089 131 6 : : PUNCT admet-2089 131 7 trx trx NOUN admet-2089 131 8 ratio ratio NOUN admet-2089 131 9 ( ( PUNCT admet-2089 131 10 10:3 10:3 NUM admet-2089 131 11 ) ) PUNCT admet-2089 131 12 was be AUX admet-2089 131 13 encapsulated encapsulate VERB admet-2089 131 14 in in ADP admet-2089 131 15 a a DET admet-2089 131 16 different different ADJ admet-2089 131 17 combination combination NOUN admet-2089 131 18 of of ADP admet-2089 131 19 epc epc PROPN admet-2089 131 20 : : PUNCT admet-2089 131 21 cholesterol cholesterol NOUN admet-2089 131 22 ( ( PUNCT admet-2089 131 23 8:2 8:2 NUM admet-2089 131 24 , , PUNCT admet-2089 131 25 7:3 7:3 NUM admet-2089 131 26 , , PUNCT admet-2089 131 27 6:4 6:4 NUM admet-2089 131 28 ) ) PUNCT admet-2089 131 29 and and CCONJ admet-2089 131 30 investigated investigate VERB admet-2089 131 31 the the DET admet-2089 131 32 release release NOUN admet-2089 131 33 kinetics kinetic NOUN admet-2089 131 34 . . PUNCT admet-2089 132 1 the the DET admet-2089 132 2 percentage percentage NOUN admet-2089 132 3 release release NOUN admet-2089 132 4 of of ADP admet-2089 132 5 trx trx NOUN admet-2089 132 6 was be AUX admet-2089 132 7 found find VERB admet-2089 132 8 to to PART admet-2089 132 9 be be AUX admet-2089 132 10 35.0 35.0 NUM admet-2089 132 11 % % NOUN admet-2089 132 12 , , PUNCT admet-2089 132 13 46.16 46.16 NUM admet-2089 132 14 and and CCONJ admet-2089 132 15 36.59 36.59 NUM admet-2089 132 16 % % NOUN admet-2089 132 17 with with ADP admet-2089 132 18 epc epc PROPN admet-2089 132 19 : : PUNCT admet-2089 132 20 cholesterol cholesterol NOUN admet-2089 132 21 ratios ratio NOUN admet-2089 132 22 ( ( PUNCT admet-2089 132 23 8:2 8:2 NUM admet-2089 132 24 , , PUNCT admet-2089 132 25 7:3 7:3 NUM admet-2089 132 26 , , PUNCT admet-2089 132 27 6:4 6:4 NUM admet-2089 132 28 ) ) PUNCT admet-2089 132 29 , , PUNCT admet-2089 132 30 respectively respectively ADV admet-2089 132 31 , , PUNCT admet-2089 132 32 in in ADP admet-2089 132 33 the the DET admet-2089 132 34 initial initial ADJ admet-2089 132 35 2 2 NUM admet-2089 132 36 h h NOUN admet-2089 132 37 ( ( PUNCT admet-2089 132 38 figure figure NOUN admet-2089 132 39 2b 2b NOUN admet-2089 132 40 ) ) PUNCT admet-2089 132 41 . . PUNCT admet-2089 133 1 with with ADP admet-2089 133 2 initial initial ADJ admet-2089 133 3 burst burst ADJ admet-2089 133 4 release release NOUN admet-2089 133 5 , , PUNCT admet-2089 133 6 the the DET admet-2089 133 7 ratio ratio NOUN admet-2089 133 8 of of ADP admet-2089 133 9 7:3 7:3 NUM admet-2089 133 10 had have VERB admet-2089 133 11 stable stable ADJ admet-2089 133 12 and and CCONJ admet-2089 133 13 prolonged prolonged ADJ admet-2089 133 14 release release NOUN admet-2089 133 15 compared compare VERB admet-2089 133 16 to to ADP admet-2089 133 17 the the DET admet-2089 133 18 other other ADJ admet-2089 133 19 ratios ratio NOUN admet-2089 133 20 . . PUNCT admet-2089 134 1 nearly nearly ADV admet-2089 134 2 99.2 99.2 NUM admet-2089 134 3 % % NOUN admet-2089 134 4 was be AUX admet-2089 134 5 released release VERB admet-2089 134 6 in in ADP admet-2089 134 7 10 10 NUM admet-2089 134 8 hours hour NOUN admet-2089 134 9 . . PUNCT admet-2089 135 1 trx trx NOUN admet-2089 135 2 proteins protein NOUN admet-2089 135 3 are be AUX admet-2089 135 4 amphipathic amphipathic ADJ admet-2089 135 5 by by ADP admet-2089 135 6 nature nature NOUN admet-2089 135 7 ; ; PUNCT admet-2089 135 8 they they PRON admet-2089 135 9 associate associate VERB admet-2089 135 10 with with ADP admet-2089 135 11 the the DET admet-2089 135 12 lipid lipid NOUN admet-2089 135 13 bilayer bilayer NOUN admet-2089 135 14 , , PUNCT admet-2089 135 15 and and CCONJ admet-2089 135 16 at at ADP admet-2089 135 17 the the DET admet-2089 135 18 same same ADJ admet-2089 135 19 time time NOUN admet-2089 135 20 , , PUNCT admet-2089 135 21 their their PRON admet-2089 135 22 hydrophilic hydrophilic ADJ admet-2089 135 23 tails tail NOUN admet-2089 135 24 may may AUX admet-2089 135 25 project project VERB admet-2089 135 26 on on ADP admet-2089 135 27 the the DET admet-2089 135 28 surface surface NOUN admet-2089 136 1 [ [ X admet-2089 136 2 33 33 NUM admet-2089 136 3 ] ] PUNCT admet-2089 136 4 . . PUNCT admet-2089 137 1 the the DET admet-2089 137 2 release release NOUN admet-2089 137 3 of of ADP admet-2089 137 4 electrostatically electrostatically ADJ admet-2089 137 5 surface surface NOUN admet-2089 137 6 adsorbed adsorb VERB admet-2089 137 7 antigens antigen NOUN admet-2089 137 8 gives give VERB admet-2089 137 9 the the DET admet-2089 137 10 initial initial ADJ admet-2089 137 11 burst burst ADJ admet-2089 137 12 release release NOUN admet-2089 137 13 when when SCONJ admet-2089 137 14 incorporated incorporate VERB admet-2089 137 15 into into ADP admet-2089 137 16 pbs pbs PROPN admet-2089 137 17 . . PUNCT admet-2089 138 1 but but CCONJ admet-2089 138 2 there there PRON admet-2089 138 3 is be VERB admet-2089 138 4 a a DET admet-2089 138 5 stable stable ADJ admet-2089 138 6 release release NOUN admet-2089 138 7 after after ADP admet-2089 138 8 that that PRON admet-2089 138 9 . . PUNCT admet-2089 139 1 this this DET admet-2089 139 2 stability stability NOUN admet-2089 139 3 is be AUX admet-2089 139 4 postulated postulate VERB admet-2089 139 5 to to ADP admet-2089 139 6 the the DET admet-2089 139 7 fact fact NOUN admet-2089 139 8 that that SCONJ admet-2089 139 9 the the DET admet-2089 139 10 incorporation incorporation NOUN admet-2089 139 11 of of ADP admet-2089 139 12 cholesterol cholesterol NOUN admet-2089 139 13 in in ADP admet-2089 139 14 epc epc PROPN admet-2089 139 15 significantly significantly ADV admet-2089 139 16 reduces reduce VERB admet-2089 139 17 the the DET admet-2089 139 18 release release NOUN admet-2089 139 19 of of ADP admet-2089 139 20 proteins protein NOUN admet-2089 139 21 from from ADP admet-2089 139 22 liposomes liposome NOUN admet-2089 139 23 [ [ X admet-2089 139 24 10 10 NUM admet-2089 139 25 ] ] PUNCT admet-2089 139 26 . . PUNCT admet-2089 140 1 it it PRON admet-2089 140 2 leads lead VERB admet-2089 140 3 to to ADP admet-2089 140 4 a a DET admet-2089 140 5 comparatively comparatively ADV admet-2089 140 6 gradual gradual ADJ admet-2089 140 7 release release NOUN admet-2089 140 8 of of ADP admet-2089 140 9 trx trx NOUN admet-2089 140 10 , , PUNCT admet-2089 140 11 along along ADP admet-2089 140 12 with with ADP admet-2089 140 13 the the DET admet-2089 140 14 disintegration disintegration NOUN admet-2089 140 15 of of ADP admet-2089 140 16 lipid lipid ADJ admet-2089 140 17 lamellae lamellae NOUN admet-2089 140 18 . . PUNCT admet-2089 141 1 sequence sequence NOUN admet-2089 141 2 retrieval retrieval NOUN admet-2089 141 3 , , PUNCT admet-2089 141 4 modelling modelling NOUN admet-2089 141 5 and and CCONJ admet-2089 141 6 validation validation NOUN admet-2089 141 7 the the DET admet-2089 141 8 fasta fasta PROPN admet-2089 141 9 sequence sequence NOUN admet-2089 141 10 of of ADP admet-2089 141 11 protein protein NOUN admet-2089 141 12 thioredoxin thioredoxin PROPN admet-2089 141 13 ( ( PUNCT admet-2089 141 14 accession accession NOUN admet-2089 141 15 i i PROPN admet-2089 141 16 d d PROPN admet-2089 141 17 is be AUX admet-2089 141 18 aam51563.1 aam51563.1 PROPN admet-2089 141 19 ) ) PUNCT admet-2089 141 20 from from ADP admet-2089 141 21 brugia brugia ADJ admet-2089 141 22 malayi malayi NOUN admet-2089 141 23 was be AUX admet-2089 141 24 retrieved retrieve VERB admet-2089 141 25 from from ADP admet-2089 141 26 ncbi ncbi PROPN admet-2089 141 27 protein protein NOUN admet-2089 141 28 . . PUNCT admet-2089 142 1 the the DET admet-2089 142 2 sequence sequence NOUN admet-2089 142 3 was be AUX admet-2089 142 4 subjected subject VERB admet-2089 142 5 to to PART admet-2089 142 6 pblast pblast VERB admet-2089 142 7 analysis analysis NOUN admet-2089 142 8 against against ADP admet-2089 142 9 a a DET admet-2089 142 10 non non ADJ admet-2089 142 11 - - ADJ admet-2089 142 12 redundant redundant ADJ admet-2089 142 13 protein protein NOUN admet-2089 142 14 sequence sequence NOUN admet-2089 142 15 database database NOUN admet-2089 142 16 , , PUNCT admet-2089 142 17 organism organism ADJ admet-2089 142 18 homo homo NOUN admet-2089 142 19 sapiens sapien VERB admet-2089 142 20 . . PUNCT admet-2089 143 1 based base VERB admet-2089 143 2 on on ADP admet-2089 143 3 the the DET admet-2089 143 4 threshold threshold NOUN admet-2089 143 5 of of ADP admet-2089 143 6 sequence sequence NOUN admet-2089 143 7 identity identity NOUN admet-2089 143 8 ≤45 ≤45 ADJ admet-2089 143 9 % % NOUN admet-2089 143 10 , , PUNCT admet-2089 143 11 it it PRON admet-2089 143 12 could could AUX admet-2089 143 13 be be AUX admet-2089 143 14 derived derive VERB admet-2089 143 15 that that SCONJ admet-2089 143 16 the the DET admet-2089 143 17 protein protein NOUN admet-2089 143 18 was be AUX admet-2089 143 19 highly highly ADV admet-2089 143 20 conserved conserved ADJ admet-2089 143 21 in in ADP admet-2089 143 22 brugia brugia ADJ admet-2089 143 23 malayi malayi NOUN admet-2089 143 24 and and CCONJ admet-2089 143 25 does do AUX admet-2089 143 26 n't not PART admet-2089 143 27 share share VERB admet-2089 143 28 homology homology NOUN admet-2089 143 29 with with ADP admet-2089 143 30 homo homo NOUN admet-2089 143 31 sapiens sapien VERB admet-2089 143 32 . . PUNCT admet-2089 144 1 the the DET admet-2089 144 2 three three NUM admet-2089 144 3 - - PUNCT admet-2089 144 4 dimensional dimensional ADJ admet-2089 144 5 model model NOUN admet-2089 144 6 of of ADP admet-2089 144 7 the the DET admet-2089 144 8 protein protein NOUN admet-2089 144 9 was be AUX admet-2089 144 10 constructed construct VERB admet-2089 144 11 using use VERB admet-2089 144 12 robetta robetta NOUN admet-2089 144 13 . . PUNCT admet-2089 145 1 ab ab PROPN admet-2089 145 2 - - PUNCT admet-2089 145 3 initio initio NOUN admet-2089 145 4 modelling modelling NOUN admet-2089 145 5 was be AUX admet-2089 145 6 performed perform VERB admet-2089 145 7 using use VERB admet-2089 145 8 the the DET admet-2089 145 9 default default NOUN admet-2089 145 10 parameters parameter NOUN admet-2089 145 11 ( ( PUNCT admet-2089 145 12 figures figure NOUN admet-2089 145 13 3a 3a NUM admet-2089 145 14 and and CCONJ admet-2089 145 15 3b 3b NUM admet-2089 145 16 ) ) PUNCT admet-2089 145 17 . . PUNCT admet-2089 146 1 figure figure VERB admet-2089 146 2 3 3 NUM admet-2089 146 3 . . PUNCT admet-2089 147 1 ( ( PUNCT admet-2089 147 2 a a X admet-2089 147 3 ) ) PUNCT admet-2089 147 4 3 3 NUM admet-2089 147 5 - - PUNCT admet-2089 147 6 d d NOUN admet-2089 147 7 model model NOUN admet-2089 147 8 of of ADP admet-2089 147 9 the the DET admet-2089 147 10 protein protein NOUN admet-2089 147 11 thioredoxin thioredoxin PROPN admet-2089 147 12 modelled model VERB admet-2089 147 13 using use VERB admet-2089 147 14 robetta robetta PROPN admet-2089 147 15 server server PROPN admet-2089 147 16 ( ( PUNCT admet-2089 147 17 b b NOUN admet-2089 147 18 ): ): PUNCT admet-2089 147 19 3 3 NUM admet-2089 147 20 - - SYM admet-2089 147 21 d d NOUN admet-2089 147 22 surface surface NOUN admet-2089 147 23 model model NOUN admet-2089 147 24 of of ADP admet-2089 147 25 the the DET admet-2089 147 26 protein protein NOUN admet-2089 147 27 thioredoxin thioredoxin PROPN admet-2089 147 28 modelled model VERB admet-2089 147 29 using use VERB admet-2089 147 30 robetta robetta PROPN admet-2089 147 31 server server NOUN admet-2089 147 32 five five NUM admet-2089 147 33 models model NOUN admet-2089 147 34 were be AUX admet-2089 147 35 generated generate VERB admet-2089 147 36 and and CCONJ admet-2089 147 37 the the DET admet-2089 147 38 best good ADJ admet-2089 147 39 model model NOUN admet-2089 147 40 was be AUX admet-2089 147 41 selected select VERB admet-2089 147 42 based base VERB admet-2089 147 43 on on ADP admet-2089 147 44 the the DET admet-2089 147 45 analysis analysis NOUN admet-2089 147 46 of of ADP admet-2089 147 47 ramachandran ramachandran NOUN admet-2089 147 48 plots plot NOUN admet-2089 147 49 . . PUNCT admet-2089 148 1 three three NUM admet-2089 148 2 - - PUNCT admet-2089 148 3 dimensional dimensional ADJ admet-2089 148 4 modelling modelling NOUN admet-2089 148 5 of of ADP admet-2089 148 6 the the DET admet-2089 148 7 proteins protein NOUN admet-2089 148 8 gives give VERB admet-2089 148 9 an an DET admet-2089 148 10 idea idea NOUN admet-2089 148 11 regarding regard VERB admet-2089 148 12 the the DET admet-2089 148 13 key key ADJ admet-2089 148 14 elements element NOUN admet-2089 148 15 in in ADP admet-2089 148 16 a a DET admet-2089 148 17 protein protein NOUN admet-2089 148 18 . . PUNCT admet-2089 149 1 it it PRON admet-2089 149 2 also also ADV admet-2089 149 3 helps help VERB admet-2089 149 4 in in ADP admet-2089 149 5 understanding understand VERB admet-2089 149 6 the the DET admet-2089 149 7 interaction interaction NOUN admet-2089 149 8 and and CCONJ admet-2089 149 9 the the DET admet-2089 149 10 molecular molecular ADJ admet-2089 149 11 dynamics dynamic NOUN admet-2089 149 12 of of ADP admet-2089 149 13 the the DET admet-2089 149 14 protein protein NOUN admet-2089 149 15 [ [ X admet-2089 149 16 34 34 NUM admet-2089 149 17 ] ] PUNCT admet-2089 149 18 . . PUNCT admet-2089 150 1 https://paperpile.com/c/plxgz5/dsll6 https://paperpile.com/c/plxgz5/dsll6 PROPN admet-2089 150 2 https://paperpile.com/c/plxgz5/hksot https://paperpile.com/c/plxgz5/hksot NOUN admet-2089 150 3 https://paperpile.com/c/plxgz5/nou41 https://paperpile.com/c/plxgz5/nou41 PROPN admet-2089 150 4 https://paperpile.com/c/plxgz5/dchei https://paperpile.com/c/plxgz5/dchei PROPN admet-2089 150 5 https://paperpile.com/c/plxgz5/ecqr https://paperpile.com/c/plxgz5/ecqr PROPN admet-2089 150 6 admet admet PROPN admet-2089 150 7 & & CCONJ admet-2089 150 8 dmpk dmpk PROPN admet-2089 150 9 12(2 12(2 NUM admet-2089 150 10 ) ) PUNCT admet-2089 150 11 ( ( PUNCT admet-2089 150 12 2024 2024 NUM admet-2089 150 13 ) ) PUNCT admet-2089 150 14 379 379 NUM admet-2089 150 15 - - SYM admet-2089 150 16 389 389 NUM admet-2089 150 17 encapsulation encapsulation NOUN admet-2089 150 18 of of ADP admet-2089 150 19 brugia brugia ADJ admet-2089 150 20 malayi malayi VERB admet-2089 150 21 thioredoxin thioredoxin PROPN admet-2089 150 22 in in ADP admet-2089 150 23 nano nano NOUN admet-2089 150 24 - - PUNCT admet-2089 150 25 liposomes liposome NOUN admet-2089 150 26 doi doi NOUN admet-2089 150 27 : : PUNCT admet-2089 150 28 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 150 29 385 385 NUM admet-2089 150 30 the the DET admet-2089 150 31 ramachandran ramachandran PROPN admet-2089 150 32 plot plot NOUN admet-2089 150 33 analysis analysis NOUN admet-2089 150 34 gives give VERB admet-2089 150 35 an an DET admet-2089 150 36 idea idea NOUN admet-2089 150 37 to to PART admet-2089 150 38 select select VERB admet-2089 150 39 the the DET admet-2089 150 40 best good ADJ admet-2089 150 41 model model NOUN admet-2089 150 42 based base VERB admet-2089 150 43 on on ADP admet-2089 150 44 several several ADJ admet-2089 150 45 parameters parameter NOUN admet-2089 150 46 , , PUNCT admet-2089 150 47 such such ADJ admet-2089 150 48 as as ADP admet-2089 150 49 the the DET admet-2089 150 50 presence presence NOUN admet-2089 150 51 of of ADP admet-2089 150 52 outliers outlier NOUN admet-2089 150 53 in in ADP admet-2089 150 54 the the DET admet-2089 150 55 number number NOUN admet-2089 150 56 of of ADP admet-2089 150 57 residues residue NOUN admet-2089 150 58 present present ADJ admet-2089 150 59 in in ADP admet-2089 150 60 the the DET admet-2089 150 61 favored favor VERB admet-2089 150 62 and and CCONJ admet-2089 150 63 allowed allow VERB admet-2089 150 64 regions region NOUN admet-2089 150 65 . . PUNCT admet-2089 151 1 based base VERB admet-2089 151 2 on on ADP admet-2089 151 3 the the DET admet-2089 151 4 ramachandran ramachandran PROPN admet-2089 151 5 plot plot NOUN admet-2089 151 6 analysis analysis NOUN admet-2089 151 7 , , PUNCT admet-2089 151 8 the the DET admet-2089 151 9 best good ADJ admet-2089 151 10 model model NOUN admet-2089 151 11 had have VERB admet-2089 151 12 98.6 98.6 NUM admet-2089 151 13 % % NOUN admet-2089 151 14 ( ( PUNCT admet-2089 151 15 141/143 141/143 PROPN admet-2089 151 16 ) ) PUNCT admet-2089 151 17 of of ADP admet-2089 151 18 all all DET admet-2089 151 19 residues residue NOUN admet-2089 151 20 in in ADP admet-2089 151 21 the the DET admet-2089 151 22 98 98 NUM admet-2089 151 23 % % NOUN admet-2089 151 24 favored favor VERB admet-2089 151 25 regions region NOUN admet-2089 151 26 and and CCONJ admet-2089 151 27 100 100 NUM admet-2089 151 28 % % NOUN admet-2089 151 29 ( ( PUNCT admet-2089 151 30 143/143 143/143 PROPN admet-2089 151 31 ) ) PUNCT admet-2089 151 32 of of ADP admet-2089 151 33 all all DET admet-2089 151 34 residues residue NOUN admet-2089 151 35 in in ADP admet-2089 151 36 the the DET admet-2089 151 37 allowed allow VERB admet-2089 151 38 regions region NOUN admet-2089 151 39 ( ( PUNCT admet-2089 151 40 > > SYM admet-2089 151 41 99.8 99.8 NUM admet-2089 151 42 % % NOUN admet-2089 151 43 ) ) PUNCT admet-2089 151 44 with with ADP admet-2089 151 45 no no DET admet-2089 151 46 outliers outlier NOUN admet-2089 151 47 ( ( PUNCT admet-2089 151 48 figures figure NOUN admet-2089 151 49 4a 4a NOUN admet-2089 151 50 and and CCONJ admet-2089 151 51 4b 4b NUM admet-2089 151 52 ) ) PUNCT admet-2089 151 53 . . PUNCT admet-2089 152 1   PROPN admet-2089 152 2 / / SYM admet-2089 152 3 ° ° PROPN admet-2089 152 4 figure figure NOUN admet-2089 152 5 4 4 NUM admet-2089 152 6 . . PUNCT admet-2089 153 1 ( ( PUNCT admet-2089 153 2 a a X admet-2089 153 3 ) ) PUNCT admet-2089 153 4 ramachandran ramachandran PROPN admet-2089 153 5 plot plot NOUN admet-2089 153 6 of of ADP admet-2089 153 7 the the DET admet-2089 153 8 modeled model VERB admet-2089 153 9 protein protein NOUN admet-2089 153 10 showing show VERB admet-2089 153 11 the the DET admet-2089 153 12 amino amino NOUN admet-2089 153 13 acid acid NOUN admet-2089 153 14 residues residue NOUN admet-2089 153 15 are be AUX admet-2089 153 16 in in ADP admet-2089 153 17 the the DET admet-2089 153 18 allowed allow VERB admet-2089 153 19 region region NOUN admet-2089 153 20 ( ( PUNCT admet-2089 153 21 b b NOUN admet-2089 153 22 ): ): PUNCT admet-2089 153 23 conformational conformational ADJ admet-2089 153 24 epitopes epitope NOUN admet-2089 153 25 predicted predict VERB admet-2089 153 26 using use VERB admet-2089 153 27 epitope3d epitope3d PROPN admet-2089 153 28 . . PUNCT admet-2089 154 1 b b X admet-2089 154 2 cell cell NOUN admet-2089 154 3 and and CCONJ admet-2089 154 4 t t NOUN admet-2089 154 5 cell cell NOUN admet-2089 154 6 epitope epitope NOUN admet-2089 154 7 prediction prediction NOUN admet-2089 154 8 and and CCONJ admet-2089 154 9 its its PRON admet-2089 154 10 properties property NOUN admet-2089 154 11 b b NOUN admet-2089 154 12 cells cell NOUN admet-2089 154 13 can can AUX admet-2089 154 14 identify identify VERB admet-2089 154 15 specific specific ADJ admet-2089 154 16 epitopes epitope NOUN admet-2089 154 17 on on ADP admet-2089 154 18 the the DET admet-2089 154 19 proteins protein NOUN admet-2089 154 20 and and CCONJ admet-2089 154 21 trigger trigger VERB admet-2089 154 22 the the DET admet-2089 154 23 differentiation differentiation NOUN admet-2089 154 24 into into ADP admet-2089 154 25 plasma plasma NOUN admet-2089 154 26 cells cell NOUN admet-2089 154 27 , , PUNCT admet-2089 154 28 which which PRON admet-2089 154 29 produce produce VERB admet-2089 154 30 antibodies antibody NOUN admet-2089 154 31 that that PRON admet-2089 154 32 help help AUX admet-2089 154 33 neutralize neutralize VERB admet-2089 154 34 and and CCONJ admet-2089 154 35 opsonization opsonization NOUN admet-2089 154 36 . . PUNCT admet-2089 155 1 the the DET admet-2089 155 2 b b NOUN admet-2089 155 3 - - PUNCT admet-2089 155 4 cell cell NOUN admet-2089 155 5 epitopes epitope NOUN admet-2089 155 6 were be AUX admet-2089 155 7 predicted predict VERB admet-2089 155 8 using using AUX admet-2089 155 9 abcpred abcpre VERB admet-2089 155 10 online online ADV admet-2089 155 11 with with ADP admet-2089 155 12 a a DET admet-2089 155 13 window window NOUN admet-2089 155 14 length length NOUN admet-2089 155 15 14 14 NUM admet-2089 155 16 and and CCONJ admet-2089 155 17 epitope epitope NOUN admet-2089 155 18 specificity specificity NOUN admet-2089 155 19 threshold threshold NOUN admet-2089 155 20 of of ADP admet-2089 155 21 0.51 0.51 NUM admet-2089 155 22 . . PUNCT admet-2089 156 1 fifteen fifteen NUM admet-2089 156 2 such such ADJ admet-2089 156 3 b b PROPN admet-2089 156 4 cell cell NOUN admet-2089 156 5 epitopes epitope NOUN admet-2089 156 6 were be AUX admet-2089 156 7 predicted predict VERB admet-2089 156 8 and and CCONJ admet-2089 156 9 tabulated tabulate VERB admet-2089 156 10 in in ADP admet-2089 156 11 table table NOUN admet-2089 156 12 1 1 NUM admet-2089 156 13 . . PUNCT admet-2089 157 1 the the DET admet-2089 157 2 epitopes epitope NOUN admet-2089 157 3 were be AUX admet-2089 157 4 ranked rank VERB admet-2089 157 5 based base VERB admet-2089 157 6 on on ADP admet-2089 157 7 the the DET admet-2089 157 8 predicted predict VERB admet-2089 157 9 scores score NOUN admet-2089 157 10 . . PUNCT admet-2089 158 1 the the DET admet-2089 158 2 predicted predict VERB admet-2089 158 3 epitopes epitope NOUN admet-2089 158 4 were be AUX admet-2089 158 5 further far ADV admet-2089 158 6 analysed analyse VERB admet-2089 158 7 for for ADP admet-2089 158 8 their their PRON admet-2089 158 9 antigenicity antigenicity NOUN admet-2089 158 10 and and CCONJ admet-2089 158 11 allergenicity allergenicity NOUN admet-2089 158 12 . . PUNCT admet-2089 159 1 vaxigen vaxigen ADJ admet-2089 159 2 server server NOUN admet-2089 159 3 was be AUX admet-2089 159 4 used use VERB admet-2089 159 5 to to PART admet-2089 159 6 predict predict VERB admet-2089 159 7 the the DET admet-2089 159 8 antigenicity antigenicity NOUN admet-2089 159 9 of of ADP admet-2089 159 10 the the DET admet-2089 159 11 given give VERB admet-2089 159 12 epitopes epitope NOUN admet-2089 159 13 . . PUNCT admet-2089 160 1 the the DET admet-2089 160 2 threshold threshold NOUN admet-2089 160 3 was be AUX admet-2089 160 4 set set VERB admet-2089 160 5 at at ADP admet-2089 160 6 0.51 0.51 NUM admet-2089 160 7 . . PUNCT admet-2089 161 1 based base VERB admet-2089 161 2 on on ADP admet-2089 161 3 the the DET admet-2089 161 4 prediction prediction NOUN admet-2089 161 5 results result NOUN admet-2089 161 6 , , PUNCT admet-2089 161 7 it it PRON admet-2089 161 8 was be AUX admet-2089 161 9 observed observe VERB admet-2089 161 10 that that SCONJ admet-2089 161 11 five five NUM admet-2089 161 12 epitopes epitope NOUN admet-2089 161 13 , , PUNCT admet-2089 161 14 i.e. i.e. X admet-2089 161 15 ldhseedlnnyvke ldhseedlnnyvke NOUN admet-2089 161 16 , , PUNCT admet-2089 161 17 pmliviksdgnvit pmliviksdgnvit PROPN admet-2089 161 18 , , PUNCT admet-2089 161 19 ksdgnvitkngrad ksdgnvitkngrad PROPN admet-2089 161 20 , , PUNCT admet-2089 161 21 crqftpilkefyee crqftpilkefyee PROPN admet-2089 161 22 and and CCONJ admet-2089 161 23 dlnnyvkeshgnwy dlnnyvkeshgnwy NOUN admet-2089 161 24 were be AUX admet-2089 161 25 antigenic antigenic ADJ admet-2089 161 26 in in ADP admet-2089 161 27 nature nature NOUN admet-2089 161 28 . . PUNCT admet-2089 162 1 allergenicity allergenicity NOUN admet-2089 162 2 was be AUX admet-2089 162 3 predicted predict VERB admet-2089 162 4 using use VERB admet-2089 162 5 the the DET admet-2089 162 6 allergen allergen NOUN admet-2089 162 7 fp fp X admet-2089 162 8 server server NOUN admet-2089 162 9 and and CCONJ admet-2089 162 10 the the DET admet-2089 162 11 epitopes epitope NOUN admet-2089 162 12 were be AUX admet-2089 162 13 recognised recognise VERB admet-2089 162 14 as as ADP admet-2089 162 15 an an DET admet-2089 162 16 allergen allergen NOUN admet-2089 162 17 / / SYM admet-2089 162 18 non non NOUN admet-2089 162 19 - - NOUN admet-2089 162 20 allergen allergen NOUN admet-2089 162 21 based base VERB admet-2089 162 22 on on ADP admet-2089 162 23 the the DET admet-2089 162 24 tanimoto tanimoto PROPN admet-2089 162 25 index index PROPN admet-2089 162 26 . . PUNCT admet-2089 163 1 from from ADP admet-2089 163 2 the the DET admet-2089 163 3 results result NOUN admet-2089 163 4 , , PUNCT admet-2089 163 5 it it PRON admet-2089 163 6 was be AUX admet-2089 163 7 seen see VERB admet-2089 163 8 that that SCONJ admet-2089 163 9 all all DET admet-2089 163 10 the the DET admet-2089 163 11 predicted predict VERB admet-2089 163 12 b b NUM admet-2089 163 13 cell cell NOUN admet-2089 163 14 epitopes epitope NOUN admet-2089 163 15 were be AUX admet-2089 163 16 non non ADJ admet-2089 163 17 - - ADJ admet-2089 163 18 allergenic allergenic ADJ admet-2089 163 19 . . PUNCT admet-2089 164 1 identification identification NOUN admet-2089 164 2 of of ADP admet-2089 164 3 antigenic antigenic ADJ admet-2089 164 4 regions region NOUN admet-2089 164 5 is be AUX admet-2089 164 6 fundamental fundamental ADJ admet-2089 164 7 for for ADP admet-2089 164 8 designing design VERB admet-2089 164 9 vaccines vaccine NOUN admet-2089 164 10 and and CCONJ admet-2089 164 11 for for ADP admet-2089 164 12 immunotherapies immunotherapy NOUN admet-2089 164 13 . . PUNCT admet-2089 165 1 it it PRON admet-2089 165 2 is be AUX admet-2089 165 3 key key ADJ admet-2089 165 4 to to PART admet-2089 165 5 identify identify VERB admet-2089 165 6 the the DET admet-2089 165 7 conformational conformational ADJ admet-2089 165 8 epitopes epitope NOUN admet-2089 165 9 in in ADP admet-2089 165 10 a a DET admet-2089 165 11 protein protein NOUN admet-2089 165 12 . . PUNCT admet-2089 166 1 epitope epitope PROPN admet-2089 166 2 3d 3d PROPN admet-2089 166 3 server server NOUN admet-2089 166 4 was be AUX admet-2089 166 5 employed employ VERB admet-2089 166 6 to to PART admet-2089 166 7 analyse analyse VERB admet-2089 166 8 the the DET admet-2089 166 9 conformational conformational ADJ admet-2089 166 10 epitopes epitope NOUN admet-2089 166 11 from from ADP admet-2089 166 12 a a DET admet-2089 166 13 three three NUM admet-2089 166 14 - - PUNCT admet-2089 166 15 dimensional dimensional ADJ admet-2089 166 16 protein protein NOUN admet-2089 166 17 structure structure NOUN admet-2089 166 18 ( ( PUNCT admet-2089 166 19 figure figure NOUN admet-2089 166 20 4b 4b PROPN admet-2089 166 21 ) ) PUNCT admet-2089 166 22 . . PUNCT admet-2089 167 1 the the DET admet-2089 167 2 shortlisted shortlist VERB admet-2089 167 3 epitopes epitope NOUN admet-2089 167 4 were be AUX admet-2089 167 5 analysed analyse VERB admet-2089 167 6 for for SCONJ admet-2089 167 7 their their PRON admet-2089 167 8 affinity affinity NOUN admet-2089 167 9 to to PART admet-2089 167 10 bind bind VERB admet-2089 167 11 with with ADP admet-2089 167 12 various various ADJ admet-2089 167 13 mhc mhc PROPN admet-2089 167 14 i i PROPN admet-2089 167 15 and and CCONJ admet-2089 167 16 mhc mhc PROPN admet-2089 167 17 ii ii PROPN admet-2089 167 18 alleles allele NOUN admet-2089 167 19 using use VERB admet-2089 167 20 net net ADJ admet-2089 167 21 mhc mhc PROPN admet-2089 167 22 servers server NOUN admet-2089 167 23 . . PUNCT admet-2089 168 1 binding bind VERB admet-2089 168 2 of of ADP admet-2089 168 3 peptides peptide NOUN admet-2089 168 4 to to ADP admet-2089 168 5 mhc mhc PROPN admet-2089 168 6 i i PROPN admet-2089 168 7 and and CCONJ admet-2089 168 8 mhc mhc PROPN admet-2089 168 9 ii ii PROPN admet-2089 168 10 receptors receptor NOUN admet-2089 168 11 allows allow VERB admet-2089 168 12 the the DET admet-2089 168 13 identification identification NOUN admet-2089 168 14 of of ADP admet-2089 168 15 the the DET admet-2089 168 16 peptides peptide NOUN admet-2089 168 17 by by ADP admet-2089 168 18 cytotoxic cytotoxic ADJ admet-2089 168 19 t t NOUN admet-2089 168 20 cells cell NOUN admet-2089 168 21 and and CCONJ admet-2089 168 22 helper helper NOUN admet-2089 168 23 t t PROPN admet-2089 168 24 cells cell NOUN admet-2089 168 25 , , PUNCT admet-2089 168 26 respectively respectively ADV admet-2089 168 27 . . PUNCT admet-2089 169 1 mhc mhc NOUN admet-2089 169 2 i i PROPN admet-2089 169 3 class class NOUN admet-2089 169 4 receptors receptor NOUN admet-2089 169 5 are be AUX admet-2089 169 6 present present ADJ admet-2089 169 7 on on ADP admet-2089 169 8 the the DET admet-2089 169 9 surface surface NOUN admet-2089 169 10 of of ADP admet-2089 169 11 all all DET admet-2089 169 12 nucleated nucleated ADJ admet-2089 169 13 cells cell NOUN admet-2089 169 14 , , PUNCT admet-2089 169 15 which which PRON admet-2089 169 16 helps helps AUX admet-2089 169 17 identify identify VERB admet-2089 169 18 endogenous endogenous ADJ admet-2089 169 19 antigens antigen NOUN admet-2089 169 20 and and CCONJ admet-2089 169 21 presents present VERB admet-2089 169 22 these these DET admet-2089 169 23 antigens antigen NOUN admet-2089 169 24 to to ADP admet-2089 169 25 cytotoxic cytotoxic ADJ admet-2089 169 26 t t NOUN admet-2089 169 27 cells cell NOUN admet-2089 169 28 . . PUNCT admet-2089 170 1 whereas whereas SCONJ admet-2089 170 2 mhc mhc PROPN admet-2089 170 3 ii ii PROPN admet-2089 170 4 is be AUX admet-2089 170 5 involved involve VERB admet-2089 170 6 in in ADP admet-2089 170 7 the the DET admet-2089 170 8 detection detection NOUN admet-2089 170 9 and and CCONJ admet-2089 170 10 binding bind VERB admet-2089 170 11 of of ADP admet-2089 170 12 exogenous exogenous ADJ admet-2089 170 13 antigens antigen NOUN admet-2089 170 14 and and CCONJ admet-2089 170 15 presents present VERB admet-2089 170 16 these these DET admet-2089 170 17 antigens antigen NOUN admet-2089 170 18 to to ADP admet-2089 170 19 helper helper NOUN admet-2089 170 20 t t PROPN admet-2089 170 21 cells cell NOUN admet-2089 170 22 . . PUNCT admet-2089 171 1 the the DET admet-2089 171 2 strong strong ADJ admet-2089 171 3 and and CCONJ admet-2089 171 4 weak weak ADJ admet-2089 171 5 binders binder NOUN admet-2089 171 6 associated associate VERB admet-2089 171 7 with with ADP admet-2089 171 8 class class NOUN admet-2089 171 9 1 1 NUM admet-2089 171 10 and and CCONJ admet-2089 171 11 2 2 NUM admet-2089 171 12 mhc mhc NOUN admet-2089 171 13 alleles allele NOUN admet-2089 171 14 are be AUX admet-2089 171 15 noted note VERB admet-2089 171 16 . . PUNCT admet-2089 172 1 there there PRON admet-2089 172 2 were be VERB admet-2089 172 3 six six NUM admet-2089 172 4 mhc mhc NOUN admet-2089 172 5 class class NOUN admet-2089 172 6 i i PRON admet-2089 172 7 alleles allele NOUN admet-2089 172 8 found find VERB admet-2089 172 9 associated associate VERB admet-2089 172 10 with with ADP admet-2089 172 11 the the DET admet-2089 172 12 selected select VERB admet-2089 172 13 epitopes epitope NOUN admet-2089 172 14 . . PUNCT admet-2089 173 1 the the DET admet-2089 173 2 alleles allele NOUN admet-2089 173 3 are be AUX admet-2089 173 4 hla hla NOUN admet-2089 173 5 - - PUNCT admet-2089 173 6 a0101 a0101 NOUN admet-2089 173 7 , , PUNCT admet-2089 173 8 hla hla NOUN admet-2089 173 9 - - PUNCT admet-2089 173 10 a2501 a2501 PROPN admet-2089 173 11 , , PUNCT admet-2089 173 12 hla hla NOUN admet-2089 173 13 - - PUNCT admet-2089 173 14 a2602 a2602 PROPN admet-2089 173 15 , , PUNCT admet-2089 173 16 hla hla PROPN admet-2089 173 17 - - PUNCT admet-2089 173 18 a8001 a8001 NOUN admet-2089 173 19 , , PUNCT admet-2089 173 20 hla hla PROPN admet-2089 173 21 - - PUNCT admet-2089 173 22 b1502 b1502 PROPN admet-2089 173 23 and and CCONJ admet-2089 173 24 hla hla PROPN admet-2089 173 25 - - PUNCT admet-2089 173 26 b1503 b1503 PROPN admet-2089 173 27 . . PUNCT admet-2089 174 1 similarly similarly ADV admet-2089 174 2 , , PUNCT admet-2089 174 3 24 24 NUM admet-2089 174 4 mhc mhc PROPN admet-2089 174 5 class class PROPN admet-2089 174 6 ii ii PROPN admet-2089 174 7 alleles allele NOUN admet-2089 174 8 were be AUX admet-2089 174 9 found find VERB admet-2089 174 10 to to PART admet-2089 174 11 be be AUX admet-2089 174 12 associated associate VERB admet-2089 174 13 with with ADP admet-2089 174 14 selected select VERB admet-2089 174 15 epitopes epitope NOUN admet-2089 174 16 . . PUNCT admet-2089 175 1 the the DET admet-2089 175 2 alleles allele NOUN admet-2089 175 3 are be AUX admet-2089 175 4 drb1_0301 drb1_0301 NOUN admet-2089 175 5 , , PUNCT admet-2089 175 6 drb1_0401 drb1_0401 NOUN admet-2089 175 7 , , PUNCT admet-2089 175 8 drb1_0403 drb1_0403 NOUN admet-2089 175 9 , , PUNCT admet-2089 175 10 drb1_0404 drb1_0404 NOUN admet-2089 175 11 , , PUNCT admet-2089 175 12 drb1_0405 drb1_0405 NOUN admet-2089 175 13 , , PUNCT admet-2089 175 14 drb1_0701 drb1_0701 ADJ admet-2089 175 15 , , PUNCT admet-2089 175 16 drb1_0802 drb1_0802 NOUN admet-2089 175 17 , , PUNCT admet-2089 175 18 drb1_1101 drb1_1101 NOUN admet-2089 175 19 , , PUNCT admet-2089 175 20 drb1_1302 drb1_1302 NOUN admet-2089 175 21 , , PUNCT admet-2089 175 22 drb1_1501 drb1_1501 NOUN admet-2089 175 23 , , PUNCT admet-2089 175 24 drb1_1602 drb1_1602 NOUN admet-2089 175 25 , , PUNCT admet-2089 175 26 drb3_0101 drb3_0101 NOUN admet-2089 175 27 , , PUNCT admet-2089 175 28 drb3_0301 drb3_0301 NOUN admet-2089 175 29 , , PUNCT admet-2089 175 30 drb4_0101 drb4_0101 NOUN admet-2089 175 31 , , PUNCT admet-2089 175 32 drb5_0101 drb5_0101 ADJ admet-2089 175 33 , , PUNCT admet-2089 175 34 hla hla NOUN admet-2089 175 35 - - PUNCT admet-2089 175 36 dpa10103 dpa10103 NOUN admet-2089 175 37 - - PUNCT admet-2089 175 38 dpb10301 dpb10301 NOUN admet-2089 175 39 , , PUNCT admet-2089 175 40 hla hla NOUN admet-2089 175 41 - - PUNCT admet-2089 175 42 dpa-10103 dpa-10103 NOUN admet-2089 175 43 - - PUNCT admet-2089 175 44 dpb10401 dpb10401 NOUN admet-2089 175 45 , , PUNCT admet-2089 175 46   NOUN admet-2089 175 47 / / SYM admet-2089 175 48 ° ° NUM admet-2089 175 49 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 ADJ admet-2089 176 1 m. m. NOUN admet-2089 176 2 balasubramaniyan balasubramaniyan PROPN admet-2089 176 3 et et PROPN admet-2089 176 4 al al PROPN admet-2089 176 5 . . PROPN admet-2089 176 6 admet admet PROPN admet-2089 176 7 & & CCONJ admet-2089 176 8 dmpk dmpk PROPN admet-2089 176 9 12(2 12(2 NUM admet-2089 176 10 ) ) PUNCT admet-2089 176 11 ( ( PUNCT admet-2089 176 12 2024 2024 NUM admet-2089 176 13 ) ) PUNCT admet-2089 176 14 379 379 NUM admet-2089 176 15 - - SYM admet-2089 176 16 389 389 NUM admet-2089 176 17 386 386 NUM admet-2089 176 18 hla hla NOUN admet-2089 176 19 - - PUNCT admet-2089 176 20 dpa10201 dpa10201 NOUN admet-2089 176 21 - - PUNCT admet-2089 176 22 dpb10101 dpb10101 NOUN admet-2089 176 23 , , PUNCT admet-2089 176 24 hla hla NOUN admet-2089 176 25 - - PUNCT admet-2089 176 26 dpa10201 dpa10201 NOUN admet-2089 176 27 - - PUNCT admet-2089 176 28 dpb10501 dpb10501 NOUN admet-2089 176 29 , , PUNCT admet-2089 176 30 hla hla NOUN admet-2089 176 31 - - PUNCT admet-2089 176 32 dpa10301 dpa10301 NOUN admet-2089 176 33 - - PUNCT admet-2089 176 34 dpb10402 dpb10402 NOUN admet-2089 176 35 , , PUNCT admet-2089 176 36 hla hla NOUN admet-2089 176 37 - - PUNCT admet-2089 176 38 dqa10102 dqa10102 NOUN admet-2089 176 39 - - PUNCT admet-2089 176 40 dqb10501 dqb10501 VERB admet-2089 176 41 , , PUNCT admet-2089 176 42 hla hla NOUN admet-2089 176 43 - - PUNCT admet-2089 176 44 dqa10301 dqa10301 NOUN admet-2089 176 45 - - PUNCT admet-2089 176 46 dqb10302 dqb10302 ADJ admet-2089 176 47 , , PUNCT admet-2089 176 48 hla hla NOUN admet-2089 176 49 - - PUNCT admet-2089 176 50 dqa10401 dqa10401 NOUN admet-2089 176 51 - - PUNCT admet-2089 176 52 dqb10402 dqb10402 NOUN admet-2089 176 53 and and CCONJ admet-2089 176 54 h-2 h-2 PROPN admet-2089 176 55 - - PUNCT admet-2089 176 56 iak iak PROPN admet-2089 176 57 . . PROPN admet-2089 176 58 immune immune PROPN admet-2089 176 59 simulation simulation NOUN admet-2089 176 60 of of ADP admet-2089 176 61 the the DET admet-2089 176 62 protein protein NOUN admet-2089 176 63 the the DET admet-2089 176 64 cimm cimm NOUN admet-2089 176 65 sim sim ADJ admet-2089 176 66 measures measure NOUN admet-2089 176 67 the the DET admet-2089 176 68 effective effective ADJ admet-2089 176 69 immune immune ADJ admet-2089 176 70 responses response NOUN admet-2089 176 71 of of ADP admet-2089 176 72 the the DET admet-2089 176 73 vaccine vaccine NOUN admet-2089 176 74 construct construct VERB admet-2089 176 75 . . PUNCT admet-2089 177 1 it it PRON admet-2089 177 2 predicts predict VERB admet-2089 177 3 immune immune ADJ admet-2089 177 4 cell cell NOUN admet-2089 177 5 memory memory NOUN admet-2089 177 6 and and CCONJ admet-2089 177 7 its its PRON admet-2089 177 8 lifespan lifespan NOUN admet-2089 177 9 based base VERB admet-2089 177 10 on on ADP admet-2089 177 11 the the DET admet-2089 177 12 cell cell NOUN admet-2089 177 13 's 's PART admet-2089 177 14 state state NOUN admet-2089 177 15 . . PUNCT admet-2089 178 1 the the DET admet-2089 178 2 server server NOUN admet-2089 178 3 results result NOUN admet-2089 178 4 showed show VERB admet-2089 178 5 consistent consistent ADJ admet-2089 178 6 immune immune ADJ admet-2089 178 7 responses response NOUN admet-2089 178 8 , , PUNCT admet-2089 178 9 with with ADP admet-2089 178 10 secondary secondary ADJ admet-2089 178 11 and and CCONJ admet-2089 178 12 tertiary tertiary ADJ admet-2089 178 13 responses response NOUN admet-2089 178 14 showing show VERB admet-2089 178 15 increased increase VERB admet-2089 178 16 activity activity NOUN admet-2089 178 17 compared compare VERB admet-2089 178 18 to to ADP admet-2089 178 19 the the DET admet-2089 178 20 primary primary ADJ admet-2089 178 21 response response NOUN admet-2089 178 22 . . PUNCT admet-2089 179 1 high high ADJ admet-2089 179 2 levels level NOUN admet-2089 179 3 of of ADP admet-2089 179 4 immunoglobulins immunoglobulin NOUN admet-2089 179 5 ( ( PUNCT admet-2089 179 6 igm igm PROPN admet-2089 179 7 , , PUNCT admet-2089 179 8 igm igm PROPN admet-2089 179 9 + + CCONJ admet-2089 179 10 igg igg PROPN admet-2089 179 11 , , PUNCT admet-2089 179 12 igg1+igg2 igg1+igg2 NOUN admet-2089 179 13 , , PUNCT admet-2089 179 14 igg1 igg1 NOUN admet-2089 179 15 , , PUNCT admet-2089 179 16 and and CCONJ admet-2089 179 17 igg2 igg2 PROPN admet-2089 179 18 ) ) PUNCT admet-2089 179 19 indicate indicate VERB admet-2089 179 20 an an DET admet-2089 179 21 immune immune ADJ admet-2089 179 22 response response NOUN admet-2089 179 23 associated associate VERB admet-2089 179 24 with with ADP admet-2089 179 25 humoral humoral ADJ admet-2089 179 26 immunity immunity NOUN admet-2089 179 27 . . PUNCT admet-2089 180 1 research research NOUN admet-2089 180 2 suggests suggest VERB admet-2089 180 3 that that SCONJ admet-2089 180 4 igg1 igg1 NOUN admet-2089 180 5 , , PUNCT admet-2089 180 6 igg2 igg2 PROPN admet-2089 180 7 , , PUNCT admet-2089 180 8 and and CCONJ admet-2089 180 9 iga iga PROPN admet-2089 180 10 antibodies antibodie VERB admet-2089 180 11 enhance enhance VERB admet-2089 180 12 bacterial bacterial ADJ admet-2089 180 13 clearance clearance NOUN admet-2089 180 14 , , PUNCT admet-2089 180 15 while while SCONJ admet-2089 180 16 igg3 igg3 PROPN admet-2089 180 17 and and CCONJ admet-2089 180 18 igg4 igg4 PROPN admet-2089 180 19 inhibit inhibit VERB admet-2089 180 20 opsonic opsonic ADJ admet-2089 180 21 activity activity NOUN admet-2089 180 22 and and CCONJ admet-2089 180 23 can can AUX admet-2089 180 24 cause cause VERB admet-2089 180 25 tissue tissue NOUN admet-2089 180 26 damage damage NOUN admet-2089 180 27 ( ( PUNCT admet-2089 180 28 figures figure NOUN admet-2089 180 29 5a-5f 5a-5f NUM admet-2089 180 30 ) ) PUNCT admet-2089 180 31 . . PUNCT admet-2089 181 1 figure figure VERB admet-2089 181 2 5 5 NUM admet-2089 181 3 . . PUNCT admet-2089 182 1 c c X admet-2089 182 2 - - PUNCT admet-2089 182 3 imm imm VERB admet-2089 182 4 sim sim ADJ admet-2089 182 5 simulation simulation NOUN admet-2089 182 6 of of ADP admet-2089 182 7 immune immune ADJ admet-2089 182 8 response response NOUN admet-2089 182 9 . . PUNCT admet-2089 183 1 ( ( PUNCT admet-2089 183 2 a a X admet-2089 183 3 ) ) PUNCT admet-2089 183 4 antigen antigen NOUN admet-2089 183 5 and and CCONJ admet-2089 183 6 immunoglobulins immunoglobulin NOUN admet-2089 183 7 . . PUNCT admet-2089 184 1 antibodies antibody NOUN admet-2089 184 2 are be AUX admet-2089 184 3 subdivided subdivide VERB admet-2089 184 4 per per ADP admet-2089 184 5 isotype isotype NOUN admet-2089 184 6 . . PUNCT admet-2089 185 1 ( ( PUNCT admet-2089 185 2 b b X admet-2089 185 3 ) ) PUNCT admet-2089 185 4 cytokines cytokine NOUN admet-2089 185 5 . . PUNCT admet-2089 186 1 concentration concentration NOUN admet-2089 186 2 of of ADP admet-2089 186 3 cytokines cytokine NOUN admet-2089 186 4 and and CCONJ admet-2089 186 5 interleukins interleukin NOUN admet-2089 186 6 . . PUNCT admet-2089 187 1 d d NOUN admet-2089 187 2 in in ADP admet-2089 187 3 the the DET admet-2089 187 4 inset inset NOUN admet-2089 187 5 plot plot NOUN admet-2089 187 6 is be AUX admet-2089 187 7 a a DET admet-2089 187 8 danger danger NOUN admet-2089 187 9 signal signal NOUN admet-2089 187 10 . . PUNCT admet-2089 188 1 ( ( PUNCT admet-2089 188 2 c c X admet-2089 188 3 ) ) PUNCT admet-2089 188 4 cd4 cd4 PROPN admet-2089 188 5 t t PROPN admet-2089 188 6 - - PUNCT admet-2089 188 7 helper helper NOUN admet-2089 188 8 lymphocytes lymphocyte NOUN admet-2089 188 9 count count VERB admet-2089 188 10 sub sub ADJ admet-2089 188 11 - - ADJ admet-2089 188 12 divided divide VERB admet-2089 188 13 per per ADP admet-2089 188 14 entity entity NOUN admet-2089 188 15 - - PUNCT admet-2089 188 16 state state NOUN admet-2089 188 17 ( ( PUNCT admet-2089 188 18 i.e. i.e. X admet-2089 188 19 active active ADJ admet-2089 188 20 , , PUNCT admet-2089 188 21 resting rest VERB admet-2089 188 22 , , PUNCT admet-2089 188 23 anergic anergic ADJ admet-2089 188 24 and and CCONJ admet-2089 188 25 duplicating duplicating NOUN admet-2089 188 26 ) ) PUNCT admet-2089 188 27 , , PUNCT admet-2089 188 28 ( ( PUNCT admet-2089 188 29 d d X admet-2089 188 30 ) ) PUNCT admet-2089 188 31 b b NOUN admet-2089 188 32 lymphocytes lymphocyte NOUN admet-2089 188 33 : : PUNCT admet-2089 188 34 total total ADJ admet-2089 188 35 count count NOUN admet-2089 188 36 , , PUNCT admet-2089 188 37 memory memory NOUN admet-2089 188 38 cells cell NOUN admet-2089 188 39 , , PUNCT admet-2089 188 40 and and CCONJ admet-2089 188 41 subdivided subdivide VERB admet-2089 188 42 in in ADP admet-2089 188 43 isotypes isotypes PROPN admet-2089 188 44 igm igm PROPN admet-2089 188 45 , , PUNCT admet-2089 188 46 igg1 igg1 NOUN admet-2089 188 47 and and CCONJ admet-2089 188 48 igg2 igg2 PROPN admet-2089 188 49 , , PUNCT admet-2089 188 50 ( ( PUNCT admet-2089 188 51 e e X admet-2089 188 52 ) ) PUNCT admet-2089 188 53 cd8 cd8 PROPN admet-2089 188 54 t t PROPN admet-2089 188 55 - - PUNCT admet-2089 188 56 cytotoxic cytotoxic ADJ admet-2089 188 57 lymphocytes lymphocyte NOUN admet-2089 188 58 count count NOUN admet-2089 188 59 per per ADP admet-2089 188 60 entity entity NOUN admet-2089 188 61 - - PUNCT admet-2089 188 62 state state NOUN admet-2089 188 63 . . PUNCT admet-2089 189 1 ( ( PUNCT admet-2089 189 2 f f X admet-2089 189 3 ) ) PUNCT admet-2089 189 4 dendritic dendritic ADJ admet-2089 189 5 cells cell NOUN admet-2089 189 6 . . PUNCT admet-2089 190 1 dc dc PROPN admet-2089 190 2 can can AUX admet-2089 190 3 present present VERB admet-2089 190 4 antigenic antigenic ADJ admet-2089 190 5 peptides peptide NOUN admet-2089 190 6 on on ADP admet-2089 190 7 both both PRON admet-2089 190 8 mhc mhc PROPN admet-2089 190 9 class class NOUN admet-2089 190 10 - - PUNCT admet-2089 190 11 i i PROPN admet-2089 190 12 and and CCONJ admet-2089 190 13 class class NOUN admet-2089 190 14 - - PUNCT admet-2089 190 15 ii ii NOUN admet-2089 190 16 molecules molecule NOUN admet-2089 190 17 . . PUNCT admet-2089 191 1 the the DET admet-2089 191 2 curves curve NOUN admet-2089 191 3 show show VERB admet-2089 191 4 the the DET admet-2089 191 5 total total ADJ admet-2089 191 6 number number NOUN admet-2089 191 7 broken break VERB admet-2089 191 8 down down ADP admet-2089 191 9 to to ADP admet-2089 191 10 active active ADJ admet-2089 191 11 , , PUNCT admet-2089 191 12 resting rest VERB admet-2089 191 13 , , PUNCT admet-2089 191 14 internalised internalised ADJ admet-2089 191 15 and and CCONJ admet-2089 191 16 presenting present VERB admet-2089 191 17 the the DET admet-2089 191 18 antigen antigen NOUN admet-2089 191 19 . . PUNCT admet-2089 192 1 admet admet PROPN admet-2089 192 2 & & CCONJ admet-2089 192 3 dmpk dmpk PROPN admet-2089 192 4 12(2 12(2 NUM admet-2089 192 5 ) ) PUNCT admet-2089 192 6 ( ( PUNCT admet-2089 192 7 2024 2024 NUM admet-2089 192 8 ) ) PUNCT admet-2089 192 9 379 379 NUM admet-2089 192 10 - - SYM admet-2089 192 11 389 389 NUM admet-2089 192 12 encapsulation encapsulation NOUN admet-2089 192 13 of of ADP admet-2089 192 14 brugia brugia ADJ admet-2089 192 15 malayi malayi VERB admet-2089 192 16 thioredoxin thioredoxin PROPN admet-2089 192 17 in in ADP admet-2089 192 18 nano nano NOUN admet-2089 192 19 - - PUNCT admet-2089 192 20 liposomes liposome NOUN admet-2089 192 21 doi doi NOUN admet-2089 192 22 : : PUNCT admet-2089 192 23 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 192 24 387 387 NUM admet-2089 192 25 the the DET admet-2089 192 26 decrease decrease NOUN admet-2089 192 27 in in ADP admet-2089 192 28 antigen antigen ADJ admet-2089 192 29 concentration concentration NOUN admet-2089 192 30 suggests suggest VERB admet-2089 192 31 an an DET admet-2089 192 32 increase increase NOUN admet-2089 192 33 in in ADP admet-2089 192 34 b b NOUN admet-2089 192 35 - - PUNCT admet-2089 192 36 cell cell NOUN admet-2089 192 37 isotype isotype NOUN admet-2089 192 38 igg1 igg1 NOUN admet-2089 192 39 and and CCONJ admet-2089 192 40 b b NOUN admet-2089 192 41 memory memory NOUN admet-2089 192 42 cells cell NOUN admet-2089 192 43 . . PUNCT admet-2089 193 1 the the DET admet-2089 193 2 responses response NOUN admet-2089 193 3 from from ADP admet-2089 193 4 memory memory NOUN admet-2089 193 5 cells cell NOUN admet-2089 193 6 indicate indicate VERB admet-2089 193 7 a a DET admet-2089 193 8 strong strong ADJ admet-2089 193 9 response response NOUN admet-2089 193 10 in in ADP admet-2089 193 11 cytotoxic cytotoxic ADJ admet-2089 193 12 and and CCONJ admet-2089 193 13 helper helper NOUN admet-2089 193 14 t t PROPN admet-2089 193 15 cell cell NOUN admet-2089 193 16 populations population NOUN admet-2089 193 17 . . PUNCT admet-2089 194 1 additionally additionally ADV admet-2089 194 2 , , PUNCT admet-2089 194 3 high high ADJ admet-2089 194 4 levels level NOUN admet-2089 194 5 of of ADP admet-2089 194 6 il-12 il-12 NOUN admet-2089 194 7 , , PUNCT admet-2089 194 8 ifn ifn NOUN admet-2089 194 9 - - PUNCT admet-2089 194 10 γ γ NOUN admet-2089 194 11 , , PUNCT admet-2089 194 12 and and CCONJ admet-2089 194 13 th1 th1 NOUN admet-2089 194 14 populations population NOUN admet-2089 194 15 were be AUX admet-2089 194 16 observed observe VERB admet-2089 194 17 during during ADP admet-2089 194 18 multiple multiple ADJ admet-2089 194 19 exposures exposure NOUN admet-2089 194 20 , , PUNCT admet-2089 194 21 suggesting suggest VERB admet-2089 194 22 the the DET admet-2089 194 23 antigenic antigenic ADJ admet-2089 194 24 nature nature NOUN admet-2089 194 25 of of ADP admet-2089 194 26 the the DET admet-2089 194 27 protein protein NOUN admet-2089 194 28 [ [ X admet-2089 194 29 35 35 NUM admet-2089 194 30 ] ] PUNCT admet-2089 194 31 . . PUNCT admet-2089 195 1 table table NOUN admet-2089 195 2 1 1 NUM admet-2089 195 3 . . PUNCT admet-2089 196 1 the the DET admet-2089 196 2 antigenicity antigenicity NOUN admet-2089 196 3 of of ADP admet-2089 196 4 predicted predict VERB admet-2089 196 5 b b PROPN admet-2089 196 6 cell cell NOUN admet-2089 196 7 epitopes epitope VERB admet-2089 196 8 all all DET admet-2089 196 9 the the DET admet-2089 196 10 epitopes epitope NOUN admet-2089 196 11 were be AUX admet-2089 196 12 found find VERB admet-2089 196 13 to to PART admet-2089 196 14 be be AUX admet-2089 196 15 non non ADJ admet-2089 196 16 - - ADJ admet-2089 196 17 allergen allergen ADJ admet-2089 196 18 . . PUNCT admet-2089 197 1 b b X admet-2089 197 2 cell cell NOUN admet-2089 197 3 epitopes epitope VERB admet-2089 197 4 antigenicity antigenicity PROPN admet-2089 197 5 rank rank NOUN admet-2089 197 6 sequence sequence NOUN admet-2089 197 7 start start VERB admet-2089 197 8 position position NOUN admet-2089 197 9 score score NOUN admet-2089 197 10 1 1 NUM admet-2089 197 11 nkyevagipmlivi nkyevagipmlivi NOUN admet-2089 198 1 101 101 NUM admet-2089 198 2 0.86 0.86 NUM admet-2089 198 3 0.3197 0.3197 NUM admet-2089 198 4 non non NOUN admet-2089 198 5 antigen antigen ADP admet-2089 198 6 2 2 NUM admet-2089 198 7 yyvpfgsseieklk yyvpfgsseieklk VERB admet-2089 198 8 87 87 NUM admet-2089 198 9 0.76 0.76 NUM admet-2089 198 10 -0.1235 -0.1235 VERB admet-2089 198 11 non non ADJ admet-2089 198 12 antigen antigen PROPN admet-2089 198 13 2 2 NUM admet-2089 198 14 alyfsahwcppcrq alyfsahwcppcrq NOUN admet-2089 198 15 31 31 NUM admet-2089 198 16 0.76 0.76 NUM admet-2089 198 17 0.3652 0.3652 NUM admet-2089 198 18 non non NOUN admet-2089 198 19 antigen antigen ADJ admet-2089 198 20 3 3 NUM admet-2089 198 21 ldhseedlnnyvke ldhseedlnnyvke NOUN admet-2089 198 22 68 68 NUM admet-2089 198 23 0.75 0.75 NUM admet-2089 198 24 0.6018 0.6018 NUM admet-2089 198 25 antigen antigen ADP admet-2089 198 26 4 4 NUM admet-2089 198 27 pmliviksdgnvit pmliviksdgnvit NOUN admet-2089 198 28 109 109 NUM admet-2089 198 29 0.74 0.74 NUM admet-2089 198 30 1.1595 1.1595 NUM admet-2089 198 31 antigen antigen ADV admet-2089 198 32 5 5 NUM admet-2089 198 33 dqfeivfvsldhse dqfeivfvsldhse NOUN admet-2089 198 34 59 59 NUM admet-2089 198 35 0.72 0.72 NUM admet-2089 198 36 -0.0136 -0.0136 X admet-2089 198 37 non non NOUN admet-2089 199 1 antigen antigen ADV admet-2089 200 1 6 6 NUM admet-2089 200 2 nlkkadgtvkkgsd nlkkadgtvkkgsd ADJ admet-2089 200 3 9 9 NUM admet-2089 200 4 0.69 0.69 NUM admet-2089 200 5 0.0201 0.0201 NUM admet-2089 200 6 non non ADJ admet-2089 200 7 antigen antigen ADP admet-2089 200 8 6 6 NUM admet-2089 200 9 adllaninlkkadg adllaninlkkadg NOUN admet-2089 200 10 2 2 NUM admet-2089 200 11 0.69 0.69 NUM admet-2089 200 12 0.161 0.161 NUM admet-2089 200 13 non non NOUN admet-2089 200 14 antigen antigen ADP admet-2089 200 15 7 7 NUM admet-2089 200 16 ksdgnvitkngrad ksdgnvitkngrad NOUN admet-2089 200 17 115 115 NUM admet-2089 200 18 0.61 0.61 NUM admet-2089 200 19 1.2459 1.2459 NUM admet-2089 200 20 antigen antigen ADP admet-2089 200 21 8 8 NUM admet-2089 200 22 crqftpilkefyee crqftpilkefyee NOUN admet-2089 200 23 42 42 NUM admet-2089 200 24 0.59 0.59 NUM admet-2089 200 25 0.9215 0.9215 NUM admet-2089 200 26 antigen antigen ADJ admet-2089 200 27 9 9 NUM admet-2089 200 28 vkeshgnwyyvpfg vkeshgnwyyvpfg NOUN admet-2089 200 29 79 79 NUM admet-2089 200 30 0.57 0.57 NUM admet-2089 200 31 0.2245 0.2245 NUM admet-2089 200 32 non non NOUN admet-2089 200 33 antigen antigen ADJ admet-2089 200 34 9 9 NUM admet-2089 200 35 dlnnyvkeshgnwy dlnnyvkeshgnwy NOUN admet-2089 200 36 74 74 NUM admet-2089 200 37 0.57 0.57 NUM admet-2089 200 38 0.6565 0.6565 NUM admet-2089 200 39 antigen antigen ADP admet-2089 200 40 9 9 NUM admet-2089 200 41 hwcppcrqftpilk hwcppcrqftpilk NOUN admet-2089 200 42 37 37 NUM admet-2089 200 43 0.57 0.57 NUM admet-2089 200 44 -0.0531 -0.0531 ADP admet-2089 200 45 non non ADJ admet-2089 200 46 antigen antigen PROPN admet-2089 200 47 10 10 NUM admet-2089 200 48 sseieklknkyeva sseieklknkyeva VERB admet-2089 200 49 93 93 NUM admet-2089 200 50 0.56 0.56 NUM admet-2089 200 51 0.1791 0.1791 NUM admet-2089 200 52 non non ADJ admet-2089 200 53 antigen antigen ADJ admet-2089 200 54 11 11 NUM admet-2089 200 55 kgsdalankkvval kgsdalankkvval NOUN admet-2089 200 56 19 19 NUM admet-2089 200 57 0.54 0.54 NUM admet-2089 200 58 -0.0033 -0.0033 X admet-2089 200 59 non non ADJ admet-2089 201 1 antigen antigen PROPN admet-2089 202 1 conclusions conclusion NOUN admet-2089 202 2 narrow narrow VERB admet-2089 202 3 polydispersed polydisperse VERB admet-2089 202 4 liposomes liposome NOUN admet-2089 202 5 with with ADP admet-2089 202 6 a a DET admet-2089 202 7 mean mean ADJ admet-2089 202 8 diameter diameter NOUN admet-2089 202 9 of of ADP admet-2089 202 10 209 209 NUM admet-2089 202 11 nm nm NOUN admet-2089 202 12 were be AUX admet-2089 202 13 prepared prepare VERB admet-2089 202 14 using use VERB admet-2089 202 15 thin thin ADJ admet-2089 202 16 film film NOUN admet-2089 202 17 hydration hydration NOUN admet-2089 202 18 followed follow VERB admet-2089 202 19 by by ADP admet-2089 202 20 sonication sonication NOUN admet-2089 202 21 ( ( PUNCT admet-2089 202 22 25 25 NUM admet-2089 202 23 cycles cycle NOUN admet-2089 202 24 ) ) PUNCT admet-2089 202 25 . . PUNCT admet-2089 203 1 filarial filarial ADJ admet-2089 203 2 antigen antigen PROPN admet-2089 203 3 , , PUNCT admet-2089 203 4 trx trx PROPN admet-2089 203 5 , , PUNCT admet-2089 203 6 was be AUX admet-2089 203 7 successfully successfully ADV admet-2089 203 8 encapsulated encapsulate VERB admet-2089 203 9 into into ADP admet-2089 203 10 the the DET admet-2089 203 11 liposomes liposome NOUN admet-2089 203 12 . . PUNCT admet-2089 204 1 the the DET admet-2089 204 2 best good ADJ admet-2089 204 3 encapsulation encapsulation NOUN admet-2089 204 4 was be AUX admet-2089 204 5 observed observe VERB admet-2089 204 6 at at ADP admet-2089 204 7 a a DET admet-2089 204 8 lipid lipid NOUN admet-2089 204 9 to to ADP admet-2089 204 10 trx trx NOUN admet-2089 204 11 ratio ratio NOUN admet-2089 204 12 of of ADP admet-2089 204 13 10:3 10:3 NUM admet-2089 204 14 . . PUNCT admet-2089 204 15 on on ADP admet-2089 204 16 comparing compare VERB admet-2089 204 17 various various ADJ admet-2089 204 18 ratios ratio NOUN admet-2089 204 19 of of ADP admet-2089 204 20 egg egg NOUN admet-2089 204 21 phosphatidylcholine phosphatidylcholine NOUN admet-2089 204 22 to to ADP admet-2089 204 23 cholesterol cholesterol NOUN admet-2089 204 24 , , PUNCT admet-2089 204 25 the the DET admet-2089 204 26 ratio ratio NOUN admet-2089 204 27 of of ADP admet-2089 204 28 07:3 07:3 PROPN admet-2089 204 29 showed show VERB admet-2089 204 30 high high ADJ admet-2089 204 31 encapsulation encapsulation NOUN admet-2089 204 32 efficiency efficiency NOUN admet-2089 204 33 and and CCONJ admet-2089 204 34 release release VERB admet-2089 204 35 up up ADP admet-2089 204 36 to to ADP admet-2089 204 37 10h 10h NUM admet-2089 204 38 at at ADP admet-2089 204 39 physiological physiological ADJ admet-2089 204 40 ph ph NOUN admet-2089 204 41 . . PUNCT admet-2089 205 1 the the DET admet-2089 205 2 presence presence NOUN admet-2089 205 3 of of ADP admet-2089 205 4 an an DET admet-2089 205 5 optimised optimise VERB admet-2089 205 6 cholesterol cholesterol NOUN admet-2089 205 7 level level NOUN admet-2089 205 8 led lead VERB admet-2089 205 9 to to ADP admet-2089 205 10 higher high ADJ admet-2089 205 11 liposome liposome NOUN admet-2089 205 12 stability stability NOUN admet-2089 205 13 , , PUNCT admet-2089 205 14 thereby thereby ADV admet-2089 205 15 lowering lower VERB admet-2089 205 16 antigen antigen ADP admet-2089 205 17 release release NOUN admet-2089 205 18 . . PUNCT admet-2089 206 1 the the DET admet-2089 206 2 in in ADP admet-2089 206 3 silico silico NOUN admet-2089 206 4 work work NOUN admet-2089 206 5 indicated indicate VERB admet-2089 206 6 that that SCONJ admet-2089 206 7 predicted predict VERB admet-2089 206 8 epitopes epitope NOUN admet-2089 206 9 in in ADP admet-2089 206 10 trx trx NOUN admet-2089 206 11 had have VERB admet-2089 206 12 high high ADJ admet-2089 206 13 antigenic antigenic ADJ admet-2089 206 14 properties property NOUN admet-2089 206 15 . . PUNCT admet-2089 207 1 overall overall ADV admet-2089 207 2 , , PUNCT admet-2089 207 3 we we PRON admet-2089 207 4 conclude conclude VERB admet-2089 207 5 that that SCONJ admet-2089 207 6 these these DET admet-2089 207 7 optimised optimise VERB admet-2089 207 8 formulae formulae NOUN admet-2089 207 9 may may AUX admet-2089 207 10 be be AUX admet-2089 207 11 used use VERB admet-2089 207 12 as as ADP admet-2089 207 13 a a DET admet-2089 207 14 vaccine vaccine NOUN admet-2089 207 15 carrier carrier NOUN admet-2089 207 16 for for ADP admet-2089 207 17 lymphatic lymphatic ADJ admet-2089 207 18 filariasis filariasis NOUN admet-2089 207 19 . . PUNCT admet-2089 208 1 acknowledgements acknowledgement NOUN admet-2089 208 2 : : PUNCT admet-2089 208 3 this this DET admet-2089 208 4 work work NOUN admet-2089 208 5 was be AUX admet-2089 208 6 supported support VERB admet-2089 208 7 by by ADP admet-2089 208 8 anna anna PROPN admet-2089 208 9 centenary centenary PROPN admet-2089 208 10 research research NOUN admet-2089 208 11 fellowship fellowship NOUN admet-2089 208 12 , , PUNCT admet-2089 208 13 anna anna PROPN admet-2089 208 14 university university PROPN admet-2089 208 15 , , PUNCT admet-2089 208 16 chennai-25 chennai-25 PROPN admet-2089 209 1 [ [ X admet-2089 209 2 grant grant NOUN admet-2089 209 3 number number NOUN admet-2089 209 4 cr cr PROPN admet-2089 209 5 / / SYM admet-2089 209 6 acrf acrf PROPN admet-2089 209 7 / / SYM admet-2089 209 8 jan.2012/50 jan.2012/50 PROPN admet-2089 209 9 ] ] PUNCT admet-2089 209 10 . . PUNCT admet-2089 210 1 we we PRON admet-2089 210 2 gratefully gratefully ADV admet-2089 210 3 acknowledge acknowledge VERB admet-2089 210 4 dr dr PROPN admet-2089 210 5 . . PROPN admet-2089 210 6 t. t. PROPN admet-2089 210 7 devasena devasena PROPN admet-2089 210 8 for for ADP admet-2089 210 9 her her PRON admet-2089 210 10 support support NOUN admet-2089 210 11 and and CCONJ admet-2089 210 12 suggestion suggestion NOUN admet-2089 210 13 during during ADP admet-2089 210 14 the the DET admet-2089 210 15 work work NOUN admet-2089 210 16 . . PUNCT admet-2089 211 1 conflict conflict NOUN admet-2089 211 2 of of ADP admet-2089 211 3 interest interest NOUN admet-2089 211 4 : : PUNCT admet-2089 211 5 the the DET admet-2089 211 6 author(s author(s PROPN admet-2089 211 7 ) ) PUNCT admet-2089 211 8 declare(s declare(s NOUN admet-2089 211 9 ) ) PUNCT admet-2089 211 10 that that SCONJ admet-2089 211 11 there there PRON admet-2089 211 12 is be VERB admet-2089 211 13 no no DET admet-2089 211 14 conflict conflict NOUN admet-2089 211 15 of of ADP admet-2089 211 16 interest interest NOUN admet-2089 211 17 regarding regard VERB admet-2089 211 18 the the DET admet-2089 211 19 publication publication NOUN admet-2089 211 20 of of ADP admet-2089 211 21 this this DET admet-2089 211 22 article article NOUN admet-2089 211 23 . . PUNCT admet-2089 212 1 references reference NOUN admet-2089 212 2 [ [ X admet-2089 212 3 1 1 NUM admet-2089 212 4 ] ] X admet-2089 212 5 m.d m.d PROPN admet-2089 212 6 . . PROPN admet-2089 212 7 stein stein PROPN admet-2089 212 8 , , PUNCT admet-2089 212 9 j.h j.h PROPN admet-2089 212 10 . . PROPN admet-2089 212 11 samet samet PROPN admet-2089 212 12 , , PUNCT admet-2089 212 13 p.g p.g PROPN admet-2089 212 14 . . PROPN admet-2089 212 15 o'connor o'connor PROPN admet-2089 212 16 . . PUNCT admet-2089 213 1 the the DET admet-2089 213 2 linkage linkage NOUN admet-2089 213 3 of of ADP admet-2089 213 4 primary primary ADJ admet-2089 213 5 care care NOUN admet-2089 213 6 services service NOUN admet-2089 213 7 with with ADP admet-2089 213 8 substance substance NOUN admet-2089 213 9 abuse abuse NOUN admet-2089 213 10 treatment treatment NOUN admet-2089 213 11 : : PUNCT admet-2089 213 12 new new ADJ admet-2089 213 13 opportunities opportunity NOUN admet-2089 213 14 for for ADP admet-2089 213 15 academic academic ADJ admet-2089 213 16 generalists generalist NOUN admet-2089 213 17 . . PUNCT admet-2089 214 1 journal journal PROPN admet-2089 214 2 of of ADP admet-2089 214 3 general general ADJ admet-2089 214 4 internal internal ADJ admet-2089 214 5 medicine medicine NOUN admet-2089 214 6 8 8 NUM admet-2089 214 7 ( ( PUNCT admet-2089 214 8 1993 1993 NUM admet-2089 214 9 ) ) PUNCT admet-2089 214 10 106 106 NUM admet-2089 214 11 - - SYM admet-2089 214 12 107 107 NUM admet-2089 214 13 . . PUNCT admet-2089 215 1 https://doi.org/10.1007/bf02599995 https://doi.org/10.1007/bf02599995 X admet-2089 216 1 [ [ X admet-2089 216 2 2 2 NUM admet-2089 216 3 ] ] PUNCT admet-2089 216 4 monitoring monitoring NOUN admet-2089 216 5 and and CCONJ admet-2089 216 6 epidemiological epidemiological ADJ admet-2089 216 7 assessment assessment NOUN admet-2089 216 8 of of ADP admet-2089 216 9 mass mass ADJ admet-2089 216 10 drug drug NOUN admet-2089 216 11 administration administration NOUN admet-2089 216 12 in in ADP admet-2089 216 13 a a DET admet-2089 216 14 global global ADJ admet-2089 216 15 programme programme NOUN admet-2089 216 16 to to PART admet-2089 216 17 eliminate eliminate VERB admet-2089 216 18 lymphatic lymphatic ADJ admet-2089 216 19 filariasis filariasis NOUN admet-2089 216 20 : : PUNCT admet-2089 216 21 a a DET admet-2089 216 22 manual manual NOUN admet-2089 216 23 for for ADP admet-2089 216 24 national national ADJ admet-2089 216 25 elimination elimination NOUN admet-2089 216 26 programmes.world programmes.world PROPN admet-2089 216 27 health health NOUN admet-2089 216 28 organization organization NOUN admet-2089 216 29 . . PUNCT admet-2089 217 1 who who PRON admet-2089 217 2 / / SYM admet-2089 217 3 htm htm PROPN admet-2089 217 4 / / SYM admet-2089 217 5 ntd ntd PROPN admet-2089 217 6 / / SYM admet-2089 217 7 pct/2011.4.(2011 pct/2011.4.(2011 NOUN admet-2089 217 8 ) ) PUNCT admet-2089 217 9 . . PUNCT admet-2089 218 1 https://iris.who.int/bitstream/handle/10665/44580/9789241501484_eng.pdf?sequence=1 https://iris.who.int/bitstream/handle/10665/44580/9789241501484_eng.pdf?sequence=1 PROPN admet-2089 219 1 [ [ X admet-2089 219 2 3 3 X admet-2089 219 3 ] ] X admet-2089 219 4 j.n j.n PROPN admet-2089 219 5 . . PROPN admet-2089 219 6 hays hay NOUN admet-2089 219 7 . . PUNCT admet-2089 220 1 the the DET admet-2089 220 2 burdens burden NOUN admet-2089 220 3 of of ADP admet-2089 220 4 disease disease NOUN admet-2089 220 5 : : PUNCT admet-2089 220 6 epidemics epidemic NOUN admet-2089 220 7 and and CCONJ admet-2089 220 8 human human ADJ admet-2089 220 9 response response NOUN admet-2089 220 10 in in ADP admet-2089 220 11 western western ADJ admet-2089 220 12 history history NOUN admet-2089 220 13 . . PUNCT admet-2089 221 1 rutgers rutgers PROPN admet-2089 221 2 university university PROPN admet-2089 221 3 press press NOUN admet-2089 221 4 ; ; PUNCT admet-2089 221 5 2009 2009 NUM admet-2089 221 6 . . PUNCT admet-2089 222 1 https://edisciplinas.usp.br/pluginfile.php/4205697/mod_resource/content/1/j.n.%20hayshttps://doi.org/10.5599/admet.2089 https://edisciplinas.usp.br/pluginfile.php/4205697/mod_resource/content/1/j.n.%20hayshttps://doi.org/10.5599/admet.2089 PROPN admet-2089 222 2 https://paperpile.com/c/plxgz5/wbnb https://paperpile.com/c/plxgz5/wbnb PROPN admet-2089 222 3 https://doi.org/10.1007/bf02599995 https://doi.org/10.1007/bf02599995 PROPN admet-2089 222 4 http://paperpile.com/b/plxgz5/sgofz http://paperpile.com/b/plxgz5/sgofz PROPN admet-2089 222 5 http://paperpile.com/b/plxgz5/sgofz http://paperpile.com/b/plxgz5/sgofz PROPN admet-2089 222 6 http://paperpile.com/b/plxgz5/sgofz http://paperpile.com/b/plxgz5/sgofz PROPN admet-2089 222 7 http://paperpile.com/b/plxgz5/sgofz http://paperpile.com/b/plxgz5/sgofz PROPN admet-2089 222 8 http://paperpile.com/b/plxgz5/sgofz http://paperpile.com/b/plxgz5/sgofz PROPN admet-2089 222 9 http://paperpile.com/b/plxgz5/sgofz http://paperpile.com/b/plxgz5/sgofz VERB admet-2089 222 10 https://iris.who.int/bitstream/handle/10665/44580/9789241501484_eng.pdf?sequence=1 https://iris.who.int/bitstream/handle/10665/44580/9789241501484_eng.pdf?sequence=1 PROPN admet-2089 222 11 http://paperpile.com/b/plxgz5/6zpui http://paperpile.com/b/plxgz5/6zpui PROPN admet-2089 222 12 http://paperpile.com/b/plxgz5/6zpui http://paperpile.com/b/plxgz5/6zpui PROPN admet-2089 222 13 http://paperpile.com/b/plxgz5/6zpui http://paperpile.com/b/plxgz5/6zpui PROPN admet-2089 223 1 http://paperpile.com/b/plxgz5/6zpui http://paperpile.com/b/plxgz5/6zpui PROPN admet-2089 223 2 https://edisciplinas.usp.br/pluginfile.php/4205697/mod_resource/content/1/j.n.%20hays-the%20burdens%20of%20disease_%20epidemics%20and%20human%20response%20in%20western%20history%2c%20revised%20edition%20%282010%29.pdf https://edisciplinas.usp.br/pluginfile.php/4205697/mod_resource/content/1/j.n.%20hays-the%20burdens%20of%20disease_%20epidemics%20and%20human%20response%20in%20western%20history%2c%20revised%20edition%20%282010%29.pdf PROPN admet-2089 223 3 m. m. PROPN admet-2089 223 4 balasubramaniyan balasubramaniyan PROPN admet-2089 223 5 et et PROPN admet-2089 223 6 al al PROPN admet-2089 223 7 . . PROPN admet-2089 223 8 admet admet PROPN admet-2089 223 9 & & CCONJ admet-2089 223 10 dmpk dmpk PROPN admet-2089 223 11 12(2 12(2 NUM admet-2089 223 12 ) ) PUNCT admet-2089 223 13 ( ( PUNCT admet-2089 223 14 2024 2024 NUM admet-2089 223 15 ) ) PUNCT admet-2089 223 16 379 379 NUM admet-2089 223 17 - - SYM admet-2089 223 18 389 389 NUM admet-2089 223 19 388 388 NUM admet-2089 223 20 the%20burdens%20of%20disease_%20epidemics%20and%20human%20response%20in%20wester the%20burdens%20of%20disease_%20epidemics%20and%20human%20response%20in%20wester NOUN admet-2089 223 21 n%20history%2c%20revised%20edition%20%282010%29.pdf n%20history%2c%20revised%20edition%20%282010%29.pdf PROPN admet-2089 224 1 [ [ X admet-2089 224 2 4 4 NUM admet-2089 224 3 ] ] X admet-2089 224 4 a.k a.k PROPN admet-2089 224 5 . . PROPN admet-2089 224 6 rana rana PROPN admet-2089 224 7 , , PUNCT admet-2089 224 8 s. s. PROPN admet-2089 224 9 misra misra PROPN admet-2089 224 10 - - PUNCT admet-2089 224 11 bhattacharya bhattacharya VERB admet-2089 224 12 . . PUNCT admet-2089 225 1 current current ADJ admet-2089 225 2 drug drug NOUN admet-2089 225 3 targets target NOUN admet-2089 225 4 for for ADP admet-2089 225 5 helminthic helminthic ADJ admet-2089 225 6 diseases disease NOUN admet-2089 225 7 . . PUNCT admet-2089 226 1 parasitol parasitol NOUN admet-2089 226 2 research research NOUN admet-2089 226 3 112 112 NUM admet-2089 226 4 ( ( PUNCT admet-2089 226 5 2013 2013 NUM admet-2089 226 6 ) ) PUNCT admet-2089 226 7 1819 1819 NUM admet-2089 226 8 - - SYM admet-2089 226 9 1831 1831 NUM admet-2089 226 10 . . PUNCT admet-2089 227 1 https://pubmed.ncbi.nlm.nih.gov/23529336/ https://pubmed.ncbi.nlm.nih.gov/23529336/ PROPN admet-2089 227 2 [ [ X admet-2089 227 3 5 5 NUM admet-2089 227 4 ] ] PUNCT admet-2089 227 5 preventive preventive ADJ admet-2089 227 6 chemotherapy chemotherapy NOUN admet-2089 227 7 in in ADP admet-2089 227 8 human human ADJ admet-2089 227 9 helminthiasis helminthiasis NOUN admet-2089 227 10 : : PUNCT admet-2089 227 11 coordinated coordinate VERB admet-2089 227 12 use use NOUN admet-2089 227 13 of of ADP admet-2089 227 14 anthelminthic anthelminthic ADJ admet-2089 227 15 drugs drug NOUN admet-2089 227 16 in in ADP admet-2089 227 17 control control NOUN admet-2089 227 18 interventions intervention NOUN admet-2089 227 19 : : PUNCT admet-2089 227 20 a a DET admet-2089 227 21 manual manual NOUN admet-2089 227 22 for for ADP admet-2089 227 23 health health NOUN admet-2089 227 24 professionals professional NOUN admet-2089 227 25 and and CCONJ admet-2089 227 26 programme programme NOUN admet-2089 227 27 managers manager NOUN admet-2089 227 28 . . PUNCT admet-2089 228 1 world world NOUN admet-2089 228 2 health health PROPN admet-2089 228 3 organization organization NOUN admet-2089 228 4 ( ( PUNCT admet-2089 228 5 2006 2006 NUM admet-2089 228 6 ) ) PUNCT admet-2089 228 7 . . PUNCT admet-2089 229 1 https://play.google.com/store/books/details?id=5qjvg5eek1cc https://play.google.com/store/books/details?id=5qjvg5eek1cc PROPN admet-2089 230 1 [ [ X admet-2089 230 2 6 6 NUM admet-2089 230 3 ] ] PUNCT admet-2089 230 4 k. k. PROPN admet-2089 230 5 kunchithapautham kunchithapautham PROPN admet-2089 230 6 , , PUNCT admet-2089 230 7 b. b. PROPN admet-2089 230 8 padmavathi padmavathi PROPN admet-2089 230 9 , , PUNCT admet-2089 230 10 r.b r.b PROPN admet-2089 230 11 . . PROPN admet-2089 230 12 narayanan narayanan PROPN admet-2089 230 13 , , PUNCT admet-2089 230 14 p. p. PROPN admet-2089 230 15 kaliraj kaliraj PROPN admet-2089 230 16 , , PUNCT admet-2089 230 17 a.l a.l PROPN admet-2089 230 18 . . PROPN admet-2089 230 19 scott scott PROPN admet-2089 230 20 . . PUNCT admet-2089 231 1 thioredoxin thioredoxin PROPN admet-2089 231 2 from from ADP admet-2089 231 3 brugiamalayi brugiamalayi NOUN admet-2089 231 4 : : PUNCT admet-2089 231 5 defining define VERB admet-2089 231 6 a a DET admet-2089 231 7 16 16 NUM admet-2089 231 8 - - PUNCT admet-2089 231 9 kilodalton kilodalton NOUN admet-2089 231 10 class class NOUN admet-2089 231 11 of of ADP admet-2089 231 12 thioredoxins thioredoxin NOUN admet-2089 231 13 from from ADP admet-2089 231 14 nematodes nematode NOUN admet-2089 231 15 . . PUNCT admet-2089 232 1 infection infection NOUN admet-2089 232 2 and and CCONJ admet-2089 232 3 immunity immunity NOUN admet-2089 232 4 71 71 NUM admet-2089 232 5 ( ( PUNCT admet-2089 232 6 2003 2003 NUM admet-2089 232 7 ) ) PUNCT admet-2089 232 8 4119 4119 NUM admet-2089 232 9 4126 4126 NUM admet-2089 232 10 . . PUNCT admet-2089 233 1 http://dx.doi.org/10.1128/iai.71.7.4119-4126.2003 http://dx.doi.org/10.1128/iai.71.7.4119-4126.2003 PUNCT admet-2089 234 1 [ [ X admet-2089 234 2 7 7 X admet-2089 234 3 ] ] X admet-2089 234 4 j. j. PROPN admet-2089 234 5 madhumathi madhumathi PROPN admet-2089 234 6 , , PUNCT admet-2089 234 7 p.r p.r PROPN admet-2089 234 8 . . PROPN admet-2089 234 9 prince prince PROPN admet-2089 234 10 , , PUNCT admet-2089 234 11 g. g. PROPN admet-2089 234 12 anugraha anugraha PROPN admet-2089 234 13 , , PUNCT admet-2089 234 14 p. p. PROPN admet-2089 234 15 kiran kiran PROPN admet-2089 234 16 , , PUNCT admet-2089 234 17 d.n d.n PROPN admet-2089 234 18 . . PROPN admet-2089 234 19 rao rao PROPN admet-2089 234 20 , , PUNCT admet-2089 234 21 m.v.r m.v.r NOUN admet-2089 234 22 . . PUNCT admet-2089 234 23 reddy reddy PROPN admet-2089 234 24 . . PUNCT admet-2089 235 1 identification identification NOUN admet-2089 235 2 and and CCONJ admet-2089 235 3 characterization characterization NOUN admet-2089 235 4 of of ADP admet-2089 235 5 nematode nematode NOUN admet-2089 235 6 specific specific ADJ admet-2089 235 7 protective protective ADJ admet-2089 235 8 epitopes epitope NOUN admet-2089 235 9 of of ADP admet-2089 235 10 brugiamalayi brugiamalayi PROPN admet-2089 235 11 trx trx NOUN admet-2089 235 12 towards towards ADP admet-2089 235 13 development development NOUN admet-2089 235 14 of of ADP admet-2089 235 15 synthetic synthetic ADJ admet-2089 235 16 vaccine vaccine NOUN admet-2089 235 17 construct construct VERB admet-2089 235 18 for for ADP admet-2089 235 19 lymphatic lymphatic ADJ admet-2089 235 20 filariasis filariasis NOUN admet-2089 235 21 . . PUNCT admet-2089 236 1 vaccine vaccine NOUN admet-2089 236 2 28 28 NUM admet-2089 236 3 ( ( PUNCT admet-2089 236 4 2010 2010 NUM admet-2089 236 5 ) ) PUNCT admet-2089 236 6 5038 5038 NUM admet-2089 236 7 - - SYM admet-2089 236 8 5048 5048 NUM admet-2089 236 9 . . PUNCT admet-2089 237 1 http://dx.doi.org/10.1016/j.vaccine.2010.05.012 http://dx.doi.org/10.1016/j.vaccine.2010.05.012 NOUN admet-2089 237 2 [ [ X admet-2089 237 3 8 8 NUM admet-2089 237 4 ] ] PUNCT admet-2089 237 5 s. s. PROPN admet-2089 237 6 ramachandran ramachandran PROPN admet-2089 237 7 , , PUNCT admet-2089 237 8 m.p m.p PROPN admet-2089 237 9 . . PROPN admet-2089 237 10 kumar kumar PROPN admet-2089 237 11 , , PUNCT admet-2089 237 12 r.m.v r.m.v NOUN admet-2089 237 13 . . PUNCT admet-2089 238 1 rami rami PROPN admet-2089 238 2 , , PUNCT admet-2089 238 3 h.b h.b PROPN admet-2089 238 4 . . PROPN admet-2089 238 5 chinnaiah chinnaiah PROPN admet-2089 238 6 , , PUNCT admet-2089 238 7 t. t. PROPN admet-2089 238 8 nutman nutman PROPN admet-2089 238 9 , , PUNCT admet-2089 238 10 p. p. NOUN admet-2089 238 11 kaliraj kaliraj PROPN admet-2089 238 12 . . PUNCT admet-2089 239 1 the the DET admet-2089 239 2 larval larval ADJ admet-2089 239 3 specific specific ADJ admet-2089 239 4 lymphatic lymphatic ADJ admet-2089 239 5 filarial filarial NOUN admet-2089 239 6 alt-2 alt-2 PUNCT admet-2089 239 7 : : PUNCT admet-2089 239 8 induction induction NOUN admet-2089 239 9 of of ADP admet-2089 239 10 protection protection NOUN admet-2089 239 11 using use VERB admet-2089 239 12 protein protein NOUN admet-2089 239 13 or or CCONJ admet-2089 239 14 dna dna NOUN admet-2089 239 15 vaccination vaccination NOUN admet-2089 239 16 . . PUNCT admet-2089 240 1 medical medical ADJ admet-2089 240 2 microbiology microbiology NOUN admet-2089 240 3 and and CCONJ admet-2089 240 4 immunology immunology NOUN admet-2089 240 5 48 48 NUM admet-2089 240 6 ( ( PUNCT admet-2089 240 7 2004 2004 NUM admet-2089 240 8 ) ) PUNCT admet-2089 240 9 945 945 NUM admet-2089 240 10 - - SYM admet-2089 240 11 955 955 NUM admet-2089 240 12 . . PUNCT admet-2089 241 1 http://dx.doi.org/10.1111/j.13480421.2004.tb03624.x http://dx.doi.org/10.1111/j.13480421.2004.tb03624.x X admet-2089 242 1 [ [ X admet-2089 242 2 9 9 NUM admet-2089 242 3 ] ] SYM admet-2089 242 4 s.b s.b PROPN admet-2089 242 5 . . PROPN admet-2089 242 6 anand anand PROPN admet-2089 242 7 , , PUNCT admet-2089 242 8 m. m. NOUN admet-2089 242 9 gnanasekar gnanasekar PROPN admet-2089 242 10 , , PUNCT admet-2089 242 11 m. m. NOUN admet-2089 242 12 thangadurai thangadurai PROPN admet-2089 242 13 , , PUNCT admet-2089 242 14 p.r p.r PROPN admet-2089 242 15 . . PROPN admet-2089 242 16 prabhu prabhu PROPN admet-2089 242 17 , , PUNCT admet-2089 242 18 p. p. NOUN admet-2089 242 19 kaliraj kaliraj PROPN admet-2089 242 20 , , PUNCT admet-2089 242 21 k. k. PROPN admet-2089 242 22 ramaswamy ramaswamy PROPN admet-2089 242 23 . . PROPN admet-2089 242 24 immune immune ADJ admet-2089 242 25 response response NOUN admet-2089 242 26 studies study NOUN admet-2089 242 27 with with ADP admet-2089 242 28 wuchereriabancroftivespid wuchereriabancroftivespid ADJ admet-2089 242 29 allergen allergen NOUN admet-2089 242 30 homologue homologue NOUN admet-2089 242 31 ( ( PUNCT admet-2089 242 32 wbvah wbvah PROPN admet-2089 242 33 ) ) PUNCT admet-2089 242 34 in in ADP admet-2089 242 35 human human ADJ admet-2089 242 36 lymphatic lymphatic ADJ admet-2089 242 37 filariasis filariasis NOUN admet-2089 242 38 . . PUNCT admet-2089 243 1 parasitology parasitology NOUN admet-2089 243 2 research research NOUN admet-2089 243 3 101 101 NUM admet-2089 243 4 ( ( PUNCT admet-2089 243 5 2007 2007 NUM admet-2089 243 6 ) ) PUNCT admet-2089 243 7 981 981 NUM admet-2089 243 8 - - SYM admet-2089 243 9 988 988 NUM admet-2089 243 10 . . PUNCT admet-2089 243 11 http://dx.doi.org/10.1007/s00436-007-0571-2 http://dx.doi.org/10.1007/s00436-007-0571-2 PUNCT admet-2089 244 1 [ [ X admet-2089 244 2 10 10 NUM admet-2089 244 3 ] ] X admet-2089 244 4 n. n. PROPN admet-2089 244 5 latif latif PROPN admet-2089 244 6 , , PUNCT admet-2089 244 7 b.k b.k PROPN admet-2089 244 8 . . PROPN admet-2089 244 9 bachhawat bachhawat PROPN admet-2089 244 10 . . PUNCT admet-2089 245 1 liposomes liposome NOUN admet-2089 245 2 in in ADP admet-2089 245 3 immunology immunology NOUN admet-2089 245 4 . . PUNCT admet-2089 246 1 the the DET admet-2089 246 2 journal journal NOUN admet-2089 246 3 of of ADP admet-2089 246 4 biosciences bioscience NOUN admet-2089 246 5 6 6 NUM admet-2089 246 6 ( ( PUNCT admet-2089 246 7 1984 1984 NUM admet-2089 246 8 ) ) PUNCT admet-2089 246 9 491 491 NUM admet-2089 246 10 - - SYM admet-2089 246 11 502 502 NUM admet-2089 246 12 . . PUNCT admet-2089 247 1 http://dx.doi.org/10.1007/bf02703901 http://dx.doi.org/10.1007/bf02703901 PROPN admet-2089 248 1 [ [ X admet-2089 248 2 11 11 NUM admet-2089 248 3 ] ] PUNCT admet-2089 248 4 r. r. PROPN admet-2089 248 5 l. l. PROPN admet-2089 248 6 richards richards PROPN admet-2089 248 7 , , PUNCT admet-2089 248 8 m. m. PROPN admet-2089 248 9 d. d. PROPN admet-2089 248 10 hayre hayre PROPN admet-2089 248 11 , , PUNCT admet-2089 248 12 w. w. PROPN admet-2089 248 13 t. t. PROPN admet-2089 248 14 hockmeyer hockmeyer PROPN admet-2089 248 15 , , PUNCT admet-2089 248 16 c. c. PROPN admet-2089 248 17 r. r. PROPN admet-2089 248 18 alving alve VERB admet-2089 248 19 . . PUNCT admet-2089 249 1 liposomes liposome NOUN admet-2089 249 2 , , PUNCT admet-2089 249 3 lipid lipid NOUN admet-2089 249 4 a a NOUN admet-2089 249 5 , , PUNCT admet-2089 249 6 and and CCONJ admet-2089 249 7 aluminum aluminum NOUN admet-2089 249 8 hydroxide hydroxide NOUN admet-2089 249 9 enhance enhance VERB admet-2089 249 10 the the DET admet-2089 249 11 immune immune ADJ admet-2089 249 12 response response NOUN admet-2089 249 13 to to ADP admet-2089 249 14 a a DET admet-2089 249 15 synthetic synthetic ADJ admet-2089 249 16 malaria malaria NOUN admet-2089 249 17 sporozoite sporozoite NOUN admet-2089 249 18 antigen antigen ADV admet-2089 249 19 . . PUNCT admet-2089 250 1 infection infection NOUN admet-2089 250 2 immunology immunology NOUN admet-2089 250 3 56(3 56(3 NOUN admet-2089 250 4 ) ) PUNCT admet-2089 250 5 ( ( PUNCT admet-2089 250 6 1988 1988 NUM admet-2089 250 7 ) ) PUNCT admet-2089 250 8 682 682 NUM admet-2089 250 9 - - SYM admet-2089 250 10 6 6 NUM admet-2089 250 11 . . PUNCT admet-2089 251 1 https://doi.org/10.1128/iai.56.3.682-686.1988 https://doi.org/10.1128/iai.56.3.682-686.1988 PROPN admet-2089 252 1 [ [ X admet-2089 252 2 12 12 NUM admet-2089 252 3 ] ] PUNCT admet-2089 252 4 a. a. NOUN admet-2089 252 5 sharma sharma PROPN admet-2089 252 6 , , PUNCT admet-2089 252 7 u.s u.s PROPN admet-2089 252 8 . . PROPN admet-2089 252 9 sharma sharma PROPN admet-2089 252 10 . . PUNCT admet-2089 253 1 liposomes liposome NOUN admet-2089 253 2 in in ADP admet-2089 253 3 drug drug NOUN admet-2089 253 4 delivery delivery NOUN admet-2089 253 5 : : PUNCT admet-2089 253 6 progress progress NOUN admet-2089 253 7 and and CCONJ admet-2089 253 8 limitations limitation NOUN admet-2089 253 9 . . PUNCT admet-2089 254 1 the the DET admet-2089 254 2 international international ADJ admet-2089 254 3 journal journal NOUN admet-2089 254 4 of of ADP admet-2089 254 5 pharmaceutics pharmaceutic NOUN admet-2089 254 6 154 154 NUM admet-2089 254 7 ( ( PUNCT admet-2089 254 8 1997 1997 NUM admet-2089 254 9 ) ) PUNCT admet-2089 254 10 123 123 NUM admet-2089 254 11 - - SYM admet-2089 254 12 140 140 NUM admet-2089 254 13 . . PUNCT admet-2089 255 1 http://dx.doi.org/10.1016/s0378-5173(97)00135-x http://dx.doi.org/10.1016/s0378-5173(97)00135-x NOUN admet-2089 256 1 [ [ X admet-2089 256 2 13 13 NUM admet-2089 256 3 ] ] PUNCT admet-2089 256 4 f. f. PROPN admet-2089 256 5 gunstone gunstone PROPN admet-2089 256 6 . . PUNCT admet-2089 257 1 vegetable vegetable ADJ admet-2089 257 2 oils oil NOUN admet-2089 257 3 in in ADP admet-2089 257 4 food food NOUN admet-2089 257 5 technology technology NOUN admet-2089 257 6 : : PUNCT admet-2089 257 7 composition composition NOUN admet-2089 257 8 , , PUNCT admet-2089 257 9 properties property NOUN admet-2089 257 10 and and CCONJ admet-2089 257 11 uses use NOUN admet-2089 257 12 . . PUNCT admet-2089 258 1 john john PROPN admet-2089 258 2 wiley wiley PROPN admet-2089 258 3 & & CCONJ admet-2089 258 4 sons son NOUN admet-2089 258 5 . . PUNCT admet-2089 259 1 2011 2011 NUM admet-2089 259 2 . . PUNCT admet-2089 260 1 https://play.google.com/store/books/details?id=lnk2tdo8_p4c https://play.google.com/store/books/details?id=lnk2tdo8_p4c PRON admet-2089 261 1 [ [ X admet-2089 261 2 14 14 NUM admet-2089 261 3 ] ] X admet-2089 261 4 s. s. PROPN admet-2089 261 5 ogawa ogawa PROPN admet-2089 261 6 , , PUNCT admet-2089 261 7 e.a e.a PROPN admet-2089 261 8 . . PROPN admet-2089 261 9 decker decker PROPN admet-2089 261 10 , , PUNCT admet-2089 261 11 d.j d.j PROPN admet-2089 261 12 . . PROPN admet-2089 261 13 mcclements mcclement NOUN admet-2089 261 14 . . PUNCT admet-2089 262 1 influence influence NOUN admet-2089 262 2 of of ADP admet-2089 262 3 environmental environmental ADJ admet-2089 262 4 conditions condition NOUN admet-2089 262 5 on on ADP admet-2089 262 6 the the DET admet-2089 262 7 stability stability NOUN admet-2089 262 8 of of ADP admet-2089 262 9 oil oil NOUN admet-2089 262 10 in in ADP admet-2089 262 11 water water NOUN admet-2089 262 12 emulsions emulsion NOUN admet-2089 262 13 containing contain VERB admet-2089 262 14 droplets droplet NOUN admet-2089 262 15 stabilized stabilize VERB admet-2089 262 16 by by ADP admet-2089 262 17 lecithin lecithin NOUN admet-2089 262 18 - - PUNCT admet-2089 262 19 chitosan chitosan NOUN admet-2089 262 20 membranes membrane NOUN admet-2089 262 21 . . PUNCT admet-2089 263 1 the the DET admet-2089 263 2 journal journal NOUN admet-2089 263 3 of of ADP admet-2089 263 4 agricultural agricultural ADJ admet-2089 263 5 and and CCONJ admet-2089 263 6 food food NOUN admet-2089 263 7 chemistry chemistry NOUN admet-2089 263 8 51 51 NUM admet-2089 263 9 ( ( PUNCT admet-2089 263 10 2003 2003 NUM admet-2089 263 11 ) ) PUNCT admet-2089 263 12 5522 5522 NUM admet-2089 263 13 - - SYM admet-2089 263 14 5527 5527 NUM admet-2089 263 15 . . PUNCT admet-2089 264 1 http://dx.doi.org/10.1021/jf026103d http://dx.doi.org/10.1021/jf026103d PRON admet-2089 265 1 [ [ X admet-2089 265 2 15 15 NUM admet-2089 265 3 ] ] X admet-2089 265 4 m.e m.e PROPN admet-2089 265 5 . . PROPN admet-2089 265 6 lanio lanio PROPN admet-2089 265 7 , , PUNCT admet-2089 265 8 m.c m.c PROPN admet-2089 265 9 . . PROPN admet-2089 265 10 luzardo luzardo PROPN admet-2089 265 11 , , PUNCT admet-2089 265 12 c. c. PROPN admet-2089 265 13 alvarez alvarez PROPN admet-2089 265 14 , , PUNCT admet-2089 265 15 y. y. PROPN admet-2089 265 16 martínez martínez PROPN admet-2089 265 17 , , PUNCT admet-2089 265 18 l. l. PROPN admet-2089 265 19 calderón calderón PROPN admet-2089 265 20 , , PUNCT admet-2089 265 21 m.e m.e PROPN admet-2089 265 22 . . PROPN admet-2089 265 23 alonso alonso PROPN admet-2089 265 24 . . PUNCT admet-2089 266 1 humoral humoral ADJ admet-2089 266 2 immune immune ADJ admet-2089 266 3 response response NOUN admet-2089 266 4 against against ADP admet-2089 266 5 epidermal epidermal ADJ admet-2089 266 6 growth growth NOUN admet-2089 266 7 factor factor NOUN admet-2089 266 8 encapsulated encapsulate VERB admet-2089 266 9 in in ADP admet-2089 266 10 dehydration dehydration NOUN admet-2089 266 11 rehydration rehydration NOUN admet-2089 266 12 vesicles vesicle NOUN admet-2089 266 13 of of ADP admet-2089 266 14 different different ADJ admet-2089 266 15 phospholipid phospholipid NOUN admet-2089 266 16 composition composition NOUN admet-2089 266 17 . . PUNCT admet-2089 267 1 journal journal NOUN admet-2089 267 2 of of ADP admet-2089 267 3 liposome liposome PROPN admet-2089 267 4 research research NOUN admet-2089 267 5 18 18 NUM admet-2089 267 6 ( ( PUNCT admet-2089 267 7 2008 2008 NUM admet-2089 267 8 ) ) PUNCT admet-2089 267 9 1 1 NUM admet-2089 267 10 - - SYM admet-2089 267 11 19 19 NUM admet-2089 267 12 . . PUNCT admet-2089 268 1 http://dx.doi.org/10.1080/08982100801893887 http://dx.doi.org/10.1080/08982100801893887 ADJ admet-2089 269 1 [ [ X admet-2089 269 2 16 16 NUM admet-2089 269 3 ] ] X admet-2089 269 4 e.m e.m PROPN admet-2089 269 5 . . PROPN admet-2089 269 6 agger agger PROPN admet-2089 269 7 , , PUNCT admet-2089 269 8 i. i. PROPN admet-2089 269 9 rosenkrands rosenkrands PROPN admet-2089 269 10 , , PUNCT admet-2089 269 11 j. j. PROPN admet-2089 269 12 hansen hansen PROPN admet-2089 269 13 , , PUNCT admet-2089 269 14 k. k. PROPN admet-2089 269 15 brahimi brahimi PROPN admet-2089 269 16 , , PUNCT admet-2089 269 17 b.s b.s PROPN admet-2089 269 18 . . PROPN admet-2089 269 19 vandahl vandahl PROPN admet-2089 269 20 , , PUNCT admet-2089 269 21 c. c. PROPN admet-2089 269 22 aagaard aagaard NOUN admet-2089 269 23 . . PUNCT admet-2089 270 1 cationic cationic ADJ admet-2089 270 2 liposomes liposome NOUN admet-2089 270 3 formulated formulate VERB admet-2089 270 4 with with ADP admet-2089 270 5 synthetic synthetic ADJ admet-2089 270 6 mycobacterial mycobacterial ADJ admet-2089 270 7 cordfactor cordfactor NOUN admet-2089 270 8 ( ( PUNCT admet-2089 270 9 caf01 caf01 PROPN admet-2089 270 10 ): ): PUNCT admet-2089 270 11 a a DET admet-2089 270 12 versatile versatile ADJ admet-2089 270 13 adjuvant adjuvant NOUN admet-2089 270 14 for for ADP admet-2089 270 15 vaccines vaccine NOUN admet-2089 270 16 with with ADP admet-2089 270 17 different different ADJ admet-2089 270 18 immunological immunological ADJ admet-2089 270 19 requirements requirement NOUN admet-2089 270 20 . . PUNCT admet-2089 271 1 plos plos PROPN admet-2089 271 2 one one NUM admet-2089 271 3 3 3 NUM admet-2089 271 4 ( ( PUNCT admet-2089 271 5 2008 2008 NUM admet-2089 271 6 ) ) PUNCT admet-2089 271 7 e3116 e3116 VERB admet-2089 271 8 . . PUNCT admet-2089 272 1 http://dx.doi.org/10.1371/journal.pone.0003116 http://dx.doi.org/10.1371/journal.pone.0003116 X admet-2089 273 1 [ [ X admet-2089 273 2 17 17 NUM admet-2089 273 3 ] ] X admet-2089 273 4 l. l. PROPN admet-2089 273 5 krishnan krishnan PROPN admet-2089 273 6 , , PUNCT admet-2089 273 7 g.d g.d PROPN admet-2089 273 8 . . PROPN admet-2089 273 9 sprott sprott PROPN admet-2089 273 10 . . PUNCT admet-2089 274 1 archaeosome archaeosome ADJ admet-2089 274 2 adjuvants adjuvant NOUN admet-2089 274 3 : : PUNCT admet-2089 274 4 immunological immunological ADJ admet-2089 274 5 capabilities capability NOUN admet-2089 274 6 and and CCONJ admet-2089 274 7 mechanism(s mechanism(s NOUN admet-2089 274 8 ) ) PUNCT admet-2089 274 9 of of ADP admet-2089 274 10 action action NOUN admet-2089 274 11 . . PUNCT admet-2089 275 1 vaccine vaccine NOUN admet-2089 275 2 26 26 NUM admet-2089 275 3 ( ( PUNCT admet-2089 275 4 2008 2008 NUM admet-2089 275 5 ) ) PUNCT admet-2089 275 6 2043 2043 NUM admet-2089 275 7 - - SYM admet-2089 275 8 2055 2055 NUM admet-2089 275 9 . . PUNCT admet-2089 276 1 http://dx.doi.org/10.1016/j.vaccine.2008.02.026 http://dx.doi.org/10.1016/j.vaccine.2008.02.026 PROPN admet-2089 277 1 [ [ X admet-2089 277 2 18 18 NUM admet-2089 277 3 ] ] PUNCT admet-2089 277 4 l. l. PROPN admet-2089 277 5 calderón calderón PROPN admet-2089 277 6 , , PUNCT admet-2089 277 7 e. e. PROPN admet-2089 277 8 facenda facenda PROPN admet-2089 277 9 , , PUNCT admet-2089 277 10 l. l. PROPN admet-2089 277 11 machado machado PROPN admet-2089 277 12 , , PUNCT admet-2089 277 13 k. k. PROPN admet-2089 277 14 uyema uyema PROPN admet-2089 277 15 , , PUNCT admet-2089 277 16 d. d. PROPN admet-2089 277 17 rodríguez rodríguez PROPN admet-2089 277 18 , , PUNCT admet-2089 277 19 e. e. PROPN admet-2089 277 20 gomez gomez PROPN admet-2089 277 21 . . PUNCT admet-2089 278 1 modulation modulation NOUN admet-2089 278 2 of of ADP admet-2089 278 3 the the DET admet-2089 278 4 specific specific ADJ admet-2089 278 5 allergic allergic ADJ admet-2089 278 6 response response NOUN admet-2089 278 7 by by ADP admet-2089 278 8 mite mite NOUN admet-2089 278 9 allergens allergen NOUN admet-2089 278 10 encapsulated encapsulate VERB admet-2089 278 11 into into ADP admet-2089 278 12 liposomes liposome NOUN admet-2089 278 13 . . PUNCT admet-2089 279 1 vaccine vaccine NOUN admet-2089 279 2 24 24 NUM admet-2089 279 3 ( ( PUNCT admet-2089 279 4 2006 2006 NUM admet-2089 279 5 ) ) PUNCT admet-2089 279 6 s38 s38 NOUN admet-2089 279 7 - - PUNCT admet-2089 279 8 s39 s39 NOUN admet-2089 279 9 . . PUNCT admet-2089 280 1 http://dx.doi.org/10.1016/j.vaccine.2005.01.112 http://dx.doi.org/10.1016/j.vaccine.2005.01.112 PROPN admet-2089 281 1 [ [ X admet-2089 281 2 19 19 NUM admet-2089 281 3 ] ] X admet-2089 281 4 s. s. PROPN admet-2089 281 5 raman raman PROPN admet-2089 281 6 , , PUNCT admet-2089 281 7 r. r. PROPN admet-2089 281 8 vernon vernon PROPN admet-2089 281 9 , , PUNCT admet-2089 281 10 j. j. PROPN admet-2089 281 11 thompson thompson PROPN admet-2089 281 12 , , PUNCT admet-2089 281 13 m. m. NOUN admet-2089 281 14 tyka tyka PROPN admet-2089 281 15 , , PUNCT admet-2089 281 16 r. r. PROPN admet-2089 281 17 sadreyev sadreyev PROPN admet-2089 281 18 , , PUNCT admet-2089 281 19 j. j. PROPN admet-2089 281 20 pei pei PROPN admet-2089 281 21 . . PUNCT admet-2089 281 22 structure structure NOUN admet-2089 281 23 prediction prediction NOUN admet-2089 281 24 for for ADP admet-2089 281 25 casp8 casp8 PROPN admet-2089 281 26 with with ADP admet-2089 281 27 all all DET admet-2089 281 28 - - PUNCT admet-2089 281 29 atom atom NOUN admet-2089 281 30 refinement refinement NOUN admet-2089 281 31 using use VERB admet-2089 281 32 rosetta rosetta PROPN admet-2089 281 33 . . PUNCT admet-2089 282 1 proteins protein NOUN admet-2089 282 2 77 77 NUM admet-2089 282 3 ( ( PUNCT admet-2089 282 4 2009 2009 NUM admet-2089 282 5 ) ) PUNCT admet-2089 282 6 89 89 NUM admet-2089 282 7 - - SYM admet-2089 282 8 99 99 NUM admet-2089 282 9 . . PUNCT admet-2089 282 10 http://dx.doi.org/10.1002/prot.22540 http://dx.doi.org/10.1002/prot.22540 PUNCT admet-2089 283 1 [ [ X admet-2089 283 2 20 20 NUM admet-2089 283 3 ] ] X admet-2089 283 4 d.w d.w PROPN admet-2089 283 5 . . PROPN admet-2089 283 6 mount mount PROPN admet-2089 283 7 . . PUNCT admet-2089 284 1 using use VERB admet-2089 284 2 the the DET admet-2089 284 3 basic basic ADJ admet-2089 284 4 local local ADJ admet-2089 284 5 alignment alignment NOUN admet-2089 284 6 search search NOUN admet-2089 284 7 tool tool NOUN admet-2089 284 8 ( ( PUNCT admet-2089 284 9 blast blast NOUN admet-2089 284 10 ) ) PUNCT admet-2089 284 11 . . PUNCT admet-2089 285 1 cold cold ADJ admet-2089 285 2 spring spring NOUN admet-2089 285 3 harbor harbor NOUN admet-2089 285 4 protocols protocol NOUN admet-2089 285 5 7 7 NUM admet-2089 285 6 ( ( PUNCT admet-2089 285 7 2007 2007 NUM admet-2089 285 8 ) ) PUNCT admet-2089 285 9 17 17 NUM admet-2089 285 10 . . PUNCT admet-2089 286 1 http://dx.doi.org/10.1101/pdb.top17 http://dx.doi.org/10.1101/pdb.top17 VERB admet-2089 286 2 https://edisciplinas.usp.br/pluginfile.php/4205697/mod_resource/content/1/j.n.%20hays-the%20burdens%20of%20disease_%20epidemics%20and%20human%20response%20in%20western%20history%2c%20revised%20edition%20%282010%29.pdf https://edisciplinas.usp.br/pluginfile.php/4205697/mod_resource/content/1/j.n.%20hays-the%20burdens%20of%20disease_%20epidemics%20and%20human%20response%20in%20western%20history%2c%20revised%20edition%20%282010%29.pdf NOUN admet-2089 286 3 https://edisciplinas.usp.br/pluginfile.php/4205697/mod_resource/content/1/j.n.%20hays-the%20burdens%20of%20disease_%20epidemics%20and%20human%20response%20in%20western%20history%2c%20revised%20edition%20%282010%29.pdf https://edisciplinas.usp.br/pluginfile.php/4205697/mod_resource/content/1/j.n.%20hays-the%20burdens%20of%20disease_%20epidemics%20and%20human%20response%20in%20western%20history%2c%20revised%20edition%20%282010%29.pdf NOUN admet-2089 286 4 https://pubmed.ncbi.nlm.nih.gov/23529336/ https://pubmed.ncbi.nlm.nih.gov/23529336/ PROPN admet-2089 286 5 http://paperpile.com/b/plxgz5/bohsx http://paperpile.com/b/plxgz5/bohsx ADV admet-2089 286 6 http://paperpile.com/b/plxgz5/bohsx http://paperpile.com/b/plxgz5/bohsx ADV admet-2089 286 7 http://paperpile.com/b/plxgz5/bohsx http://paperpile.com/b/plxgz5/bohsx ADV admet-2089 286 8 https://play.google.com/store/books/details?id=5qjvg5eek1cc https://play.google.com/store/books/details?id=5qjvg5eek1cc PROPN admet-2089 286 9 https://play.google.com/store/books/details?id=5qjvg5eek1cc https://play.google.com/store/books/details?id=5qjvg5eek1cc PART admet-2089 287 1 http://paperpile.com/b/plxgz5/r0sgz http://paperpile.com/b/plxgz5/r0sgz ADJ admet-2089 287 2 http://paperpile.com/b/plxgz5/r0sgz http://paperpile.com/b/plxgz5/r0sgz NOUN admet-2089 287 3 http://paperpile.com/b/plxgz5/r0sgz http://paperpile.com/b/plxgz5/r0sgz CCONJ admet-2089 287 4 http://dx.doi.org/10.1128/iai.71.7.4119-4126.2003 http://dx.doi.org/10.1128/iai.71.7.4119-4126.2003 NOUN admet-2089 287 5 http://paperpile.com/b/plxgz5/ajede http://paperpile.com/b/plxgz5/ajede NOUN admet-2089 287 6 http://paperpile.com/b/plxgz5/ajede http://paperpile.com/b/plxgz5/ajede NOUN admet-2089 287 7 http://paperpile.com/b/plxgz5/ajede http://paperpile.com/b/plxgz5/ajede NOUN admet-2089 287 8 http://paperpile.com/b/plxgz5/ajede http://paperpile.com/b/plxgz5/ajede NOUN admet-2089 287 9 http://dx.doi.org/10.1016/j.vaccine.2010.05.012 http://dx.doi.org/10.1016/j.vaccine.2010.05.012 PROPN admet-2089 287 10 http://paperpile.com/b/plxgz5/itnc8 http://paperpile.com/b/plxgz5/itnc8 PROPN admet-2089 288 1 http://paperpile.com/b/plxgz5/itnc8 http://paperpile.com/b/plxgz5/itnc8 NOUN admet-2089 289 1 http://paperpile.com/b/plxgz5/itnc8 http://paperpile.com/b/plxgz5/itnc8 NOUN admet-2089 290 1 http://dx.doi.org/10.1111/j.1348-0421.2004.tb03624.x http://dx.doi.org/10.1111/j.1348-0421.2004.tb03624.x PROPN admet-2089 290 2 http://dx.doi.org/10.1111/j.1348-0421.2004.tb03624.x http://dx.doi.org/10.1111/j.1348-0421.2004.tb03624.x PROPN admet-2089 291 1 http://paperpile.com/b/plxgz5/9xqs1 http://paperpile.com/b/plxgz5/9xqs1 PROPN admet-2089 291 2 http://paperpile.com/b/plxgz5/9xqs1 http://paperpile.com/b/plxgz5/9xqs1 PROPN admet-2089 291 3 http://paperpile.com/b/plxgz5/9xqs1 http://paperpile.com/b/plxgz5/9xqs1 NOUN admet-2089 291 4 http://dx.doi.org/10.1007/s00436-007-0571-2 http://dx.doi.org/10.1007/s00436-007-0571-2 PROPN admet-2089 291 5 http://paperpile.com/b/plxgz5/dchei http://paperpile.com/b/plxgz5/dchei PROPN admet-2089 291 6 http://paperpile.com/b/plxgz5/dchei http://paperpile.com/b/plxgz5/dchei PROPN admet-2089 291 7 http://dx.doi.org/10.1007/bf02703901 http://dx.doi.org/10.1007/bf02703901 PROPN admet-2089 291 8 http://paperpile.com/b/plxgz5/n8pw6 http://paperpile.com/b/plxgz5/n8pw6 PROPN admet-2089 291 9 https://doi.org/10.1128/iai.56.3.682-686.1988 https://doi.org/10.1128/iai.56.3.682-686.1988 PROPN admet-2089 292 1 http://dx.doi.org/10.1016/s0378-5173(97)00135-x http://dx.doi.org/10.1016/s0378-5173(97)00135-x NOUN admet-2089 292 2 http://paperpile.com/b/plxgz5/wnlht http://paperpile.com/b/plxgz5/wnlht AUX admet-2089 292 3 http://paperpile.com/b/plxgz5/wnlht http://paperpile.com/b/plxgz5/wnlht VERB admet-2089 292 4 https://play.google.com/store/books/details?id=lnk2tdo8_p4c https://play.google.com/store/books/details?id=lnk2tdo8_p4c NOUN admet-2089 292 5 https://play.google.com/store/books/details?id=lnk2tdo8_p4c https://play.google.com/store/books/details?id=lnk2tdo8_p4c PROPN admet-2089 292 6 http://paperpile.com/b/plxgz5/fbxza http://paperpile.com/b/plxgz5/fbxza ADJ admet-2089 292 7 http://paperpile.com/b/plxgz5/fbxza http://paperpile.com/b/plxgz5/fbxza ADJ admet-2089 292 8 http://paperpile.com/b/plxgz5/fbxza http://paperpile.com/b/plxgz5/fbxza ADJ admet-2089 292 9 http://dx.doi.org/10.1021/jf026103d http://dx.doi.org/10.1021/jf026103d PROPN admet-2089 292 10 http://paperpile.com/b/plxgz5/4fpkb http://paperpile.com/b/plxgz5/4fpkb NOUN admet-2089 292 11 http://paperpile.com/b/plxgz5/4fpkb http://paperpile.com/b/plxgz5/4fpkb PROPN admet-2089 292 12 http://paperpile.com/b/plxgz5/4fpkb http://paperpile.com/b/plxgz5/4fpkb PROPN admet-2089 292 13 http://paperpile.com/b/plxgz5/4fpkb http://paperpile.com/b/plxgz5/4fpkb PROPN admet-2089 293 1 http://dx.doi.org/10.1080/08982100801893887 http://dx.doi.org/10.1080/08982100801893887 PROPN admet-2089 293 2 http://paperpile.com/b/plxgz5/l6eug http://paperpile.com/b/plxgz5/l6eug PROPN admet-2089 293 3 http://paperpile.com/b/plxgz5/l6eug http://paperpile.com/b/plxgz5/l6eug PROPN admet-2089 293 4 http://paperpile.com/b/plxgz5/l6eug http://paperpile.com/b/plxgz5/l6eug PROPN admet-2089 293 5 http://paperpile.com/b/plxgz5/l6eug http://paperpile.com/b/plxgz5/l6eug PROPN admet-2089 294 1 http://dx.doi.org/10.1371/journal.pone.0003116 http://dx.doi.org/10.1371/journal.pone.0003116 ADV admet-2089 294 2 http://paperpile.com/b/plxgz5/wg1ja http://paperpile.com/b/plxgz5/wg1ja X admet-2089 294 3 http://paperpile.com/b/plxgz5/wg1ja http://paperpile.com/b/plxgz5/wg1ja NUM admet-2089 295 1 http://dx.doi.org/10.1016/j.vaccine.2008.02.026 http://dx.doi.org/10.1016/j.vaccine.2008.02.026 PROPN admet-2089 295 2 http://paperpile.com/b/plxgz5/9uu2q http://paperpile.com/b/plxgz5/9uu2q NOUN admet-2089 295 3 http://paperpile.com/b/plxgz5/9uu2q http://paperpile.com/b/plxgz5/9uu2q NOUN admet-2089 295 4 http://dx.doi.org/10.1016/j.vaccine.2005.01.112 http://dx.doi.org/10.1016/j.vaccine.2005.01.112 PROPN admet-2089 295 5 http://paperpile.com/b/plxgz5/cflik http://paperpile.com/b/plxgz5/cflik PROPN admet-2089 295 6 http://paperpile.com/b/plxgz5/cflik http://paperpile.com/b/plxgz5/cflik PROPN admet-2089 295 7 http://dx.doi.org/10.1002/prot.22540 http://dx.doi.org/10.1002/prot.22540 NUM admet-2089 295 8 http://dx.doi.org/10.1101/pdb.top17 http://dx.doi.org/10.1101/pdb.top17 PROPN admet-2089 295 9 admet admet PROPN admet-2089 295 10 & & CCONJ admet-2089 295 11 dmpk dmpk PROPN admet-2089 295 12 12(2 12(2 NUM admet-2089 295 13 ) ) PUNCT admet-2089 295 14 ( ( PUNCT admet-2089 295 15 2024 2024 NUM admet-2089 295 16 ) ) PUNCT admet-2089 295 17 379 379 NUM admet-2089 295 18 - - SYM admet-2089 295 19 389 389 NUM admet-2089 295 20 encapsulation encapsulation NOUN admet-2089 295 21 of of ADP admet-2089 295 22 brugia brugia ADJ admet-2089 295 23 malayi malayi VERB admet-2089 295 24 thioredoxin thioredoxin PROPN admet-2089 295 25 in in ADP admet-2089 295 26 nano nano NOUN admet-2089 295 27 - - PUNCT admet-2089 295 28 liposomes liposome NOUN admet-2089 295 29 doi doi NOUN admet-2089 295 30 : : PUNCT admet-2089 295 31 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 295 32 389 389 NUM admet-2089 295 33 [ [ X admet-2089 295 34 21 21 NUM admet-2089 295 35 ] ] X admet-2089 295 36 s. s. PROPN admet-2089 295 37 saha saha PROPN admet-2089 295 38 , , PUNCT admet-2089 295 39 g.p.s g.p.s PROPN admet-2089 295 40 . . PUNCT admet-2089 295 41 raghava raghava PROPN admet-2089 295 42 . . PUNCT admet-2089 296 1 prediction prediction NOUN admet-2089 296 2 of of ADP admet-2089 296 3 continuous continuous ADJ admet-2089 296 4 b b NOUN admet-2089 296 5 - - PUNCT admet-2089 296 6 cell cell NOUN admet-2089 296 7 epitopes epitope NOUN admet-2089 296 8 in in ADP admet-2089 296 9 an an DET admet-2089 296 10 antigen antigen NOUN admet-2089 296 11 using use VERB admet-2089 296 12 recurrent recurrent ADJ admet-2089 296 13 neural neural ADJ admet-2089 296 14 network network NOUN admet-2089 296 15 . . PUNCT admet-2089 297 1 proteins protein NOUN admet-2089 297 2 65 65 NUM admet-2089 297 3 ( ( PUNCT admet-2089 297 4 2006 2006 NUM admet-2089 297 5 ) ) PUNCT admet-2089 297 6 40 40 NUM admet-2089 297 7 - - SYM admet-2089 297 8 48 48 NUM admet-2089 297 9 . . PUNCT admet-2089 298 1 http://dx.doi.org/10.1002/prot.21078 http://dx.doi.org/10.1002/prot.21078 PRON admet-2089 299 1 [ [ X admet-2089 299 2 22 22 NUM admet-2089 299 3 ] ] X admet-2089 299 4 i.a i.a PROPN admet-2089 299 5 . . PROPN admet-2089 299 6 doytchinova doytchinova PROPN admet-2089 299 7 , , PUNCT admet-2089 299 8 d.r d.r PROPN admet-2089 299 9 . . PROPN admet-2089 299 10 flower flower PROPN admet-2089 299 11 . . PUNCT admet-2089 300 1 vaxijen vaxijen NOUN admet-2089 300 2 : : PUNCT admet-2089 300 3 a a DET admet-2089 300 4 server server NOUN admet-2089 300 5 for for ADP admet-2089 300 6 prediction prediction NOUN admet-2089 300 7 of of ADP admet-2089 300 8 protective protective ADJ admet-2089 300 9 antigens antigen NOUN admet-2089 300 10 , , PUNCT admet-2089 300 11 tumour tumour NOUN admet-2089 300 12 antigens antigen NOUN admet-2089 300 13 and and CCONJ admet-2089 300 14 subunit subunit NOUN admet-2089 300 15 vaccines vaccine NOUN admet-2089 300 16 . . PUNCT admet-2089 301 1 bmc bmc ADJ admet-2089 301 2 bioinformatics bioinformatics NOUN admet-2089 301 3 8 8 NUM admet-2089 301 4 ( ( PUNCT admet-2089 301 5 2007 2007 NUM admet-2089 301 6 ) ) PUNCT admet-2089 301 7 4 4 NUM admet-2089 301 8 . . PUNCT admet-2089 302 1 http://dx.doi.org/10.1186/1471-2105-8-4 http://dx.doi.org/10.1186/1471-2105-8-4 PROPN admet-2089 302 2 [ [ X admet-2089 302 3 23 23 NUM admet-2089 302 4 ] ] X admet-2089 302 5 i. i. NOUN admet-2089 302 6 dimitrov dimitrov PROPN admet-2089 302 7 , , PUNCT admet-2089 302 8 l. l. PROPN admet-2089 302 9 naneva naneva PROPN admet-2089 302 10 , , PUNCT admet-2089 302 11 i. i. PROPN admet-2089 302 12 doytchinova doytchinova PROPN admet-2089 302 13 , , PUNCT admet-2089 302 14 i. i. PROPN admet-2089 302 15 bangovi bangovi PROPN admet-2089 302 16 . . PUNCT admet-2089 303 1 allergenfp allergenfp NOUN admet-2089 303 2 : : PUNCT admet-2089 303 3 allergenicity allergenicity NOUN admet-2089 303 4 prediction prediction NOUN admet-2089 303 5 by by ADP admet-2089 303 6 descriptor descriptor NOUN admet-2089 303 7 fingerprints fingerprint NOUN admet-2089 303 8 . . PUNCT admet-2089 304 1 bioinformatics bioinformatic NOUN admet-2089 304 2 30 30 NUM admet-2089 304 3 ( ( PUNCT admet-2089 304 4 2014 2014 NUM admet-2089 304 5 ) ) PUNCT admet-2089 304 6 846 846 NUM admet-2089 304 7 - - SYM admet-2089 304 8 851 851 NUM admet-2089 304 9 . . PUNCT admet-2089 304 10 http://dx.doi.org/10.1093/bioinformatics/btt619 http://dx.doi.org/10.1093/bioinformatics/btt619 X admet-2089 305 1 [ [ X admet-2089 305 2 24 24 NUM admet-2089 305 3 ] ] X admet-2089 305 4 b.m b.m PROPN admet-2089 305 5 . . PROPN admet-2089 305 6 da da PROPN admet-2089 305 7 silva silva PROPN admet-2089 305 8 , , PUNCT admet-2089 305 9 y. y. PROPN admet-2089 305 10 myung myung PROPN admet-2089 305 11 , , PUNCT admet-2089 305 12 d.b d.b PROPN admet-2089 305 13 . . PROPN admet-2089 305 14 ascher ascher PROPN admet-2089 305 15 , , PUNCT admet-2089 305 16 d.e.v d.e.v PROPN admet-2089 305 17 . . PUNCT admet-2089 305 18 pires pires PROPN admet-2089 305 19 . . PUNCT admet-2089 306 1 epitope3d epitope3d PROPN admet-2089 306 2 : : PUNCT admet-2089 306 3 a a DET admet-2089 306 4 machine machine NOUN admet-2089 306 5 learning learn VERB admet-2089 306 6 method method NOUN admet-2089 306 7 for for ADP admet-2089 306 8 conformational conformational ADJ admet-2089 306 9 b b NOUN admet-2089 306 10 - - PUNCT admet-2089 306 11 cell cell NOUN admet-2089 306 12 epitope epitope NOUN admet-2089 306 13 prediction prediction NOUN admet-2089 306 14 . . PUNCT admet-2089 307 1 briefings briefing NOUN admet-2089 307 2 in in ADP admet-2089 307 3 bioinformatics bioinformatics NOUN admet-2089 307 4 23 23 NUM admet-2089 307 5 ( ( PUNCT admet-2089 307 6 2022 2022 NUM admet-2089 307 7 ) ) PUNCT admet-2089 307 8 423 423 NUM admet-2089 307 9 . . PUNCT admet-2089 307 10 http://dx.doi.org/10.1093/bib/bbab423 http://dx.doi.org/10.1093/bib/bbab423 NOUN admet-2089 308 1 [ [ X admet-2089 308 2 25 25 NUM admet-2089 308 3 ] ] PUNCT admet-2089 308 4 m. m. PROPN admet-2089 308 5 nielsen nielsen PROPN admet-2089 308 6 , , PUNCT admet-2089 308 7 c. c. PROPN admet-2089 308 8 lundegaard lundegaard PROPN admet-2089 308 9 , , PUNCT admet-2089 308 10 p. p. NOUN admet-2089 308 11 worning worning NOUN admet-2089 308 12 , , PUNCT admet-2089 308 13 s.l s.l PROPN admet-2089 308 14 . . PROPN admet-2089 308 15 lauemøller lauemøller PROPN admet-2089 308 16 , , PUNCT admet-2089 308 17 k. k. PROPN admet-2089 308 18 lamberth lamberth PROPN admet-2089 308 19 , , PUNCT admet-2089 308 20 s. s. PROPN admet-2089 308 21 buus buus PROPN admet-2089 308 22 . . PUNCT admet-2089 309 1 reliable reliable ADJ admet-2089 309 2 prediction prediction NOUN admet-2089 309 3 of of ADP admet-2089 309 4 tcell tcell NOUN admet-2089 309 5 epitopes epitope NOUN admet-2089 309 6 using use VERB admet-2089 309 7 neural neural ADJ admet-2089 309 8 networks network NOUN admet-2089 309 9 with with ADP admet-2089 309 10 novel novel ADJ admet-2089 309 11 sequence sequence NOUN admet-2089 309 12 representations representation NOUN admet-2089 309 13 . . PUNCT admet-2089 310 1 protein protein NOUN admet-2089 310 2 science science NOUN admet-2089 310 3 12 12 NUM admet-2089 310 4 ( ( PUNCT admet-2089 310 5 2003 2003 NUM admet-2089 310 6 ) ) PUNCT admet-2089 310 7 1007 1007 NUM admet-2089 310 8 - - SYM admet-2089 310 9 1017 1017 NUM admet-2089 310 10 . . PUNCT admet-2089 311 1 http://dx.doi.org/10.1110/ps.0239403 http://dx.doi.org/10.1110/ps.0239403 NOUN admet-2089 312 1 [ [ X admet-2089 312 2 26 26 NUM admet-2089 312 3 ] ] PUNCT admet-2089 312 4 k. k. PROPN admet-2089 312 5 k. k. PROPN admet-2089 312 6 jensen jensen PROPN admet-2089 312 7 , , PUNCT admet-2089 312 8 m. m. NOUN admet-2089 312 9 andreatta andreatta NOUN admet-2089 312 10 , , PUNCT admet-2089 312 11 p. p. NOUN admet-2089 312 12 marcatili marcatili NOUN admet-2089 312 13 , , PUNCT admet-2089 312 14 s. s. PROPN admet-2089 312 15 buus buus PROPN admet-2089 312 16 , , PUNCT admet-2089 312 17 j.a j.a PROPN admet-2089 312 18 . . PROPN admet-2089 312 19 greenbaum greenbaum PROPN admet-2089 312 20 , , PUNCT admet-2089 312 21 z. z. PROPN admet-2089 312 22 yan yan PROPN admet-2089 312 23 . . PROPN admet-2089 313 1 improved improve VERB admet-2089 313 2 methods method NOUN admet-2089 313 3 for for ADP admet-2089 313 4 predicting predict VERB admet-2089 313 5 peptide peptide ADJ admet-2089 313 6 binding bind VERB admet-2089 313 7 affinity affinity NOUN admet-2089 313 8 to to ADP admet-2089 313 9 mhc mhc PROPN admet-2089 313 10 class class PROPN admet-2089 313 11 ii ii PROPN admet-2089 313 12 molecules molecule NOUN admet-2089 313 13 . . PUNCT admet-2089 314 1 immunology immunology NOUN admet-2089 314 2 154 154 NUM admet-2089 314 3 ( ( PUNCT admet-2089 314 4 2018 2018 NUM admet-2089 314 5 ) ) PUNCT admet-2089 314 6 394 394 NUM admet-2089 314 7 - - SYM admet-2089 314 8 406 406 NUM admet-2089 314 9 . . PUNCT admet-2089 315 1 http://dx.doi.org/10.1111/imm.12889 http://dx.doi.org/10.1111/imm.12889 NOUN admet-2089 316 1 [ [ X admet-2089 316 2 27 27 NUM admet-2089 316 3 ] ] X admet-2089 316 4 n. n. NOUN admet-2089 316 5 rapin rapin NOUN admet-2089 316 6 , , PUNCT admet-2089 316 7 o. o. PROPN admet-2089 316 8 lund lund PROPN admet-2089 316 9 , , PUNCT admet-2089 316 10 m. m. NOUN admet-2089 316 11 bernaschi bernaschi PROPN admet-2089 316 12 , , PUNCT admet-2089 316 13 f. f. PROPN admet-2089 316 14 castiglione castiglione PROPN admet-2089 316 15 . . PUNCT admet-2089 317 1 computational computational ADJ admet-2089 317 2 immunology immunology NOUN admet-2089 317 3 meets meet VERB admet-2089 317 4 bioinformatics bioinformatic NOUN admet-2089 317 5 : : PUNCT admet-2089 317 6 the the DET admet-2089 317 7 use use NOUN admet-2089 317 8 of of ADP admet-2089 317 9 prediction prediction NOUN admet-2089 317 10 tools tool NOUN admet-2089 317 11 for for ADP admet-2089 317 12 molecular molecular ADJ admet-2089 317 13 binding binding NOUN admet-2089 317 14 in in ADP admet-2089 317 15 the the DET admet-2089 317 16 simulation simulation NOUN admet-2089 317 17 of of ADP admet-2089 317 18 the the DET admet-2089 317 19 immune immune ADJ admet-2089 317 20 system system NOUN admet-2089 317 21 . . PUNCT admet-2089 318 1 plos plos PROPN admet-2089 318 2 one one NUM admet-2089 318 3 5 5 NUM admet-2089 318 4 ( ( PUNCT admet-2089 318 5 2010 2010 NUM admet-2089 318 6 ) ) PUNCT admet-2089 318 7 e9862 e9862 PROPN admet-2089 318 8 . . PUNCT admet-2089 319 1 http://dx.doi.org/10.1371/journal.pone.0009862 http://dx.doi.org/10.1371/journal.pone.0009862 PROPN admet-2089 319 2 [ [ X admet-2089 319 3 28 28 NUM admet-2089 319 4 ] ] X admet-2089 319 5 e.d e.d PROPN admet-2089 319 6 . . PROPN admet-2089 319 7 korn korn PROPN admet-2089 319 8 . . PUNCT admet-2089 320 1 methods method NOUN admet-2089 320 2 in in ADP admet-2089 320 3 membrane membrane NOUN admet-2089 320 4 biology biology NOUN admet-2089 320 5 : : PUNCT admet-2089 320 6 volume volume NOUN admet-2089 320 7 1 1 NUM admet-2089 320 8 . . PUNCT admet-2089 320 9 springer springer PROPN admet-2089 320 10 science science PROPN admet-2089 320 11 & & CCONJ admet-2089 320 12 business business NOUN admet-2089 320 13 media medium NOUN admet-2089 320 14 ( ( PUNCT admet-2089 320 15 2013 2013 NUM admet-2089 320 16 ) ) PUNCT admet-2089 320 17 . . PUNCT admet-2089 321 1 https://link.springer.com/book/10.1007/978-1-4615-7422-4 https://link.springer.com/book/10.1007/978-1-4615-7422-4 PROPN admet-2089 321 2 . . PUNCT admet-2089 322 1 [ [ X admet-2089 322 2 29 29 NUM admet-2089 322 3 ] ] X admet-2089 322 4 m.x m.x PROPN admet-2089 322 5 . . PROPN admet-2089 322 6 chen chen PROPN admet-2089 322 7 , , PUNCT admet-2089 322 8 b.k b.k PROPN admet-2089 322 9 . . PROPN admet-2089 322 10 li li PROPN admet-2089 322 11 , , PUNCT admet-2089 322 12 d.k d.k PROPN admet-2089 322 13 . . PROPN admet-2089 322 14 yin yin PROPN admet-2089 322 15 , , PUNCT admet-2089 322 16 j. j. PROPN admet-2089 322 17 liang liang PROPN admet-2089 322 18 , , PUNCT admet-2089 322 19 s.s s.s PROPN admet-2089 322 20 . . PROPN admet-2089 322 21 li li PROPN admet-2089 322 22 , , PUNCT admet-2089 322 23 d.y d.y PROPN admet-2089 322 24 . . PROPN admet-2089 322 25 peng peng PROPN admet-2089 322 26 . . PUNCT admet-2089 322 27 layer layer NOUN admet-2089 322 28 - - PUNCT admet-2089 322 29 by by ADP admet-2089 322 30 - - PUNCT admet-2089 322 31 layer layer NOUN admet-2089 322 32 assembly assembly NOUN admet-2089 322 33 of of ADP admet-2089 322 34 chitosan chitosan NOUN admet-2089 322 35 stabilized stabilize VERB admet-2089 322 36 multilayered multilayered ADJ admet-2089 322 37 liposomes liposome NOUN admet-2089 322 38 for for ADP admet-2089 322 39 paclitaxel paclitaxel PROPN admet-2089 322 40 delivery delivery NOUN admet-2089 322 41 . . PUNCT admet-2089 323 1 carbohydrate carbohydrate ADJ admet-2089 323 2 polymers polymer NOUN admet-2089 323 3 111 111 NUM admet-2089 323 4 ( ( PUNCT admet-2089 323 5 2014 2014 NUM admet-2089 323 6 ) ) PUNCT admet-2089 323 7 298 298 NUM admet-2089 323 8 - - SYM admet-2089 323 9 304 304 NUM admet-2089 323 10 . . PUNCT admet-2089 324 1 http://dx.doi.org/10.1016/j.carbpol.2014.04.038 http://dx.doi.org/10.1016/j.carbpol.2014.04.038 PROPN admet-2089 325 1 [ [ X admet-2089 325 2 30 30 NUM admet-2089 325 3 ] ] X admet-2089 325 4 c. c. PROPN admet-2089 325 5 puglia puglia PROPN admet-2089 325 6 , , PUNCT admet-2089 325 7 a. a. NOUN admet-2089 325 8 offerta offerta PROPN admet-2089 325 9 , , PUNCT admet-2089 325 10 l. l. PROPN admet-2089 325 11 rizza rizza PROPN admet-2089 325 12 , , PUNCT admet-2089 325 13 g. g. PROPN admet-2089 325 14 zingale zingale PROPN admet-2089 325 15 , , PUNCT admet-2089 325 16 f. f. PROPN admet-2089 325 17 bonina bonina PROPN admet-2089 325 18 , , PUNCT admet-2089 325 19 s. s. PROPN admet-2089 325 20 ronsisvalle ronsisvalle PROPN admet-2089 325 21 . . PUNCT admet-2089 326 1 optimization optimization NOUN admet-2089 326 2 of of ADP admet-2089 326 3 curcumin curcumin NOUN admet-2089 326 4 loaded load VERB admet-2089 326 5 lipid lipid NOUN admet-2089 326 6 nanoparticles nanoparticle NOUN admet-2089 326 7 formulated formulate VERB admet-2089 326 8 using use VERB admet-2089 326 9 high high ADJ admet-2089 326 10 shear shear NOUN admet-2089 326 11 homogenization homogenization NOUN admet-2089 326 12 ( ( PUNCT admet-2089 326 13 hsh hsh PROPN admet-2089 326 14 ) ) PUNCT admet-2089 326 15 and and CCONJ admet-2089 326 16 ultrasonication ultrasonication NOUN admet-2089 326 17 ( ( PUNCT admet-2089 326 18 us we PRON admet-2089 326 19 ) ) PUNCT admet-2089 326 20 methods method NOUN admet-2089 326 21 . . PUNCT admet-2089 327 1 journal journal PROPN admet-2089 327 2 of of ADP admet-2089 327 3 nanoscience nanoscience PROPN admet-2089 327 4 and and CCONJ admet-2089 327 5 nanotechnology nanotechnology NOUN admet-2089 327 6 13 13 NUM admet-2089 327 7 ( ( PUNCT admet-2089 327 8 2013 2013 NUM admet-2089 327 9 ) ) PUNCT admet-2089 327 10 6888 6888 NUM admet-2089 327 11 - - SYM admet-2089 327 12 6893 6893 NUM admet-2089 327 13 . . PUNCT admet-2089 328 1 http://dx.doi.org/10.1166/jnn.2013.7766 http://dx.doi.org/10.1166/jnn.2013.7766 X admet-2089 329 1 [ [ X admet-2089 329 2 31 31 NUM admet-2089 329 3 ] ] PUNCT admet-2089 329 4 l. l. PROPN admet-2089 329 5 coderch coderch PROPN admet-2089 329 6 , , PUNCT admet-2089 329 7 j. j. PROPN admet-2089 329 8 fonollosa fonollosa PROPN admet-2089 329 9 , , PUNCT admet-2089 329 10 m. m. NOUN admet-2089 329 11 de de PROPN admet-2089 329 12 pera pera PROPN admet-2089 329 13 , , PUNCT admet-2089 329 14 j. j. PROPN admet-2089 329 15 estelrich estelrich PROPN admet-2089 329 16 , , PUNCT admet-2089 329 17 a. a. PROPN admet-2089 329 18 de de PROPN admet-2089 329 19 la la PROPN admet-2089 329 20 maza maza PROPN admet-2089 329 21 , , PUNCT admet-2089 329 22 j.l j.l PROPN admet-2089 329 23 . . PROPN admet-2089 329 24 parra parra PROPN admet-2089 329 25 . . PUNCT admet-2089 330 1 influence influence NOUN admet-2089 330 2 of of ADP admet-2089 330 3 cholesterol cholesterol NOUN admet-2089 330 4 on on ADP admet-2089 330 5 liposome liposome NOUN admet-2089 330 6 fluidity fluidity NOUN admet-2089 330 7 by by ADP admet-2089 330 8 epr epr PROPN admet-2089 330 9 . . PROPN admet-2089 330 10 relationship relationship NOUN admet-2089 330 11 with with ADP admet-2089 330 12 percutaneous percutaneous ADJ admet-2089 330 13 absorption absorption NOUN admet-2089 330 14 . . PUNCT admet-2089 331 1 journal journal PROPN admet-2089 331 2 of of ADP admet-2089 331 3 controlled control VERB admet-2089 331 4 release release NOUN admet-2089 331 5 68 68 NUM admet-2089 331 6 ( ( PUNCT admet-2089 331 7 2000 2000 NUM admet-2089 331 8 ) ) PUNCT admet-2089 331 9 85 85 NUM admet-2089 331 10 - - SYM admet-2089 331 11 95 95 NUM admet-2089 331 12 . . PUNCT admet-2089 332 1 http://dx.doi.org/10.1016/s0168-3659(00)00240-6 http://dx.doi.org/10.1016/s0168-3659(00)00240-6 PROPN admet-2089 333 1 [ [ X admet-2089 333 2 32 32 NUM admet-2089 333 3 ] ] X admet-2089 333 4 d.a d.a PROPN admet-2089 333 5 . . PROPN admet-2089 333 6 tyrrell tyrrell PROPN admet-2089 333 7 , , PUNCT admet-2089 333 8 t.d t.d PROPN admet-2089 333 9 . . PROPN admet-2089 333 10 heath heath PROPN admet-2089 333 11 , , PUNCT admet-2089 333 12 c.m c.m PROPN admet-2089 333 13 . . PROPN admet-2089 333 14 colley colley PROPN admet-2089 333 15 , , PUNCT admet-2089 333 16 b.e b.e PROPN admet-2089 333 17 . . PROPN admet-2089 333 18 ryman ryman PROPN admet-2089 333 19 . . PUNCT admet-2089 334 1 new new ADJ admet-2089 334 2 aspects aspect NOUN admet-2089 334 3 of of ADP admet-2089 334 4 liposomes liposome NOUN admet-2089 334 5 . . PUNCT admet-2089 335 1 biochimica biochimica PROPN admet-2089 335 2 et et PROPN admet-2089 335 3 biophysica biophysica PROPN admet-2089 335 4 acta acta PROPN admet-2089 335 5 457 457 NUM admet-2089 335 6 ( ( PUNCT admet-2089 335 7 1976 1976 NUM admet-2089 335 8 ) ) PUNCT admet-2089 335 9 259 259 NUM admet-2089 335 10 -302 -302 PROPN admet-2089 335 11 . . PUNCT admet-2089 335 12 http://dx.doi.org/10.1016/0304-4157(76)90002-2 http://dx.doi.org/10.1016/0304-4157(76)90002-2 X admet-2089 336 1 [ [ X admet-2089 336 2 33 33 NUM admet-2089 336 3 ] ] X admet-2089 336 4 r r NOUN admet-2089 336 5 tantipolphan tantipolphan NOUN admet-2089 336 6 , , PUNCT admet-2089 336 7 t. t. PROPN admet-2089 336 8 rades rades PROPN admet-2089 336 9 , , PUNCT admet-2089 336 10 n.j n.j PROPN admet-2089 336 11 . . PROPN admet-2089 336 12 medlicott medlicott PROPN admet-2089 336 13 . . PUNCT admet-2089 337 1 swelling swell VERB admet-2089 337 2 lecithin lecithin NOUN admet-2089 337 3 : : PUNCT admet-2089 337 4 cholesterol cholesterol NOUN admet-2089 337 5 implants implant NOUN admet-2089 337 6 for for ADP admet-2089 337 7 the the DET admet-2089 337 8 controlled control VERB admet-2089 337 9 release release NOUN admet-2089 337 10 of of ADP admet-2089 337 11 proteins protein NOUN admet-2089 337 12 . . PUNCT admet-2089 338 1 journal journal NOUN admet-2089 338 2 of of ADP admet-2089 338 3 liposome liposome PROPN admet-2089 338 4 research research NOUN admet-2089 338 5 19 19 NUM admet-2089 338 6 ( ( PUNCT admet-2089 338 7 2009 2009 NUM admet-2089 338 8 ) ) PUNCT admet-2089 338 9 37 37 NUM admet-2089 338 10 48 48 NUM admet-2089 338 11 . . PUNCT admet-2089 339 1 http://dx.doi.org/10.1080/08982100802636434 http://dx.doi.org/10.1080/08982100802636434 VERB admet-2089 340 1 [ [ X admet-2089 340 2 34 34 NUM admet-2089 340 3 ] ] X admet-2089 340 4 m.l m.l PROPN admet-2089 340 5 . . PROPN admet-2089 340 6 dunkley dunkley PROPN admet-2089 340 7 , , PUNCT admet-2089 340 8 s. s. PROPN admet-2089 340 9 rajyaguru rajyaguru PROPN admet-2089 340 10 , , PUNCT admet-2089 340 11 a. a. PROPN admet-2089 340 12 mccue mccue PROPN admet-2089 340 13 , , PUNCT admet-2089 340 14 a.w a.w PROPN admet-2089 340 15 . . PROPN admet-2089 340 16 cripps cripps PROPN admet-2089 340 17 , , PUNCT admet-2089 341 1 j.m j.m PROPN admet-2089 341 2 . . PROPN admet-2089 341 3 kyd kyd PROPN admet-2089 341 4 . . PUNCT admet-2089 342 1 pseudomonas pseudomona VERB admet-2089 342 2 aeruginosa aeruginosa NOUN admet-2089 342 3 - - PUNCT admet-2089 342 4 specific specific ADJ admet-2089 342 5 igg1 igg1 NOUN admet-2089 342 6 and and CCONJ admet-2089 342 7 igg2 igg2 NOUN admet-2089 342 8 subclasses subclass NOUN admet-2089 342 9 in in ADP admet-2089 342 10 enhancement enhancement NOUN admet-2089 342 11 of of ADP admet-2089 342 12 pulmonary pulmonary ADJ admet-2089 342 13 clearance clearance NOUN admet-2089 342 14 following follow VERB admet-2089 342 15 passive passive ADJ admet-2089 342 16 immunisation immunisation NOUN admet-2089 342 17 in in ADP admet-2089 342 18 the the DET admet-2089 342 19 rat rat NOUN admet-2089 342 20 . . PROPN admet-2089 343 1 fems fems PROPN admet-2089 343 2 immunology immunology NOUN admet-2089 343 3 and and CCONJ admet-2089 343 4 medical medical ADJ admet-2089 343 5 microbiology microbiology NOUN admet-2089 343 6 39 39 NUM admet-2089 343 7 ( ( PUNCT admet-2089 343 8 2003 2003 NUM admet-2089 343 9 ) ) PUNCT admet-2089 343 10 37 37 NUM admet-2089 343 11 - - SYM admet-2089 343 12 44 44 NUM admet-2089 343 13 . . PUNCT admet-2089 344 1 http://dx.doi.org/10.1016/s09288244(03)00176-7 http://dx.doi.org/10.1016/s09288244(03)00176-7 PRON admet-2089 344 2 [ [ NOUN admet-2089 344 3 35 35 NUM admet-2089 344 4 ] ] X admet-2089 344 5 s. s. PROPN admet-2089 344 6 aminnezhad aminnezhad PROPN admet-2089 344 7 , , PUNCT admet-2089 344 8 a. a. PROPN admet-2089 344 9 abdi abdi PROPN admet-2089 344 10 - - PUNCT admet-2089 344 11 ali ali PROPN admet-2089 344 12 , , PUNCT admet-2089 344 13 t. t. PROPN admet-2089 344 14 ghazanfari ghazanfari PROPN admet-2089 344 15 , , PUNCT admet-2089 344 16 m. m. NOUN admet-2089 344 17 bandehpour bandehpour NOUN admet-2089 344 18 , , PUNCT admet-2089 344 19 m. m. NOUN admet-2089 344 20 zarrabi zarrabi NOUN admet-2089 344 21 . . PUNCT admet-2089 345 1 immunoinformatics immunoinformatic NOUN admet-2089 345 2 design design PROPN admet-2089 345 3 of of ADP admet-2089 345 4 multivalent multivalent NOUN admet-2089 345 5 chimeric chimeric ADJ admet-2089 345 6 vaccine vaccine NOUN admet-2089 345 7 for for ADP admet-2089 345 8 modulation modulation NOUN admet-2089 345 9 of of ADP admet-2089 345 10 the the DET admet-2089 345 11 immune immune ADJ admet-2089 345 12 system system NOUN admet-2089 345 13 in in ADP admet-2089 345 14 pseudomonas pseudomona NOUN admet-2089 345 15 aeruginosa aeruginosa NOUN admet-2089 345 16 infection infection NOUN admet-2089 345 17 . . PUNCT admet-2089 346 1 infection infection NOUN admet-2089 346 2 , , PUNCT admet-2089 346 3 genetics genetic NOUN admet-2089 346 4 and and CCONJ admet-2089 346 5 evolution evolution NOUN admet-2089 346 6 85 85 NUM admet-2089 346 7 ( ( PUNCT admet-2089 346 8 2020 2020 NUM admet-2089 346 9 ) ) PUNCT admet-2089 346 10 104462 104462 NUM admet-2089 346 11 . . PUNCT admet-2089 347 1 http://dx.doi.org/10.1016/j.meegid.2020.104462 http://dx.doi.org/10.1016/j.meegid.2020.104462 PROPN admet-2089 348 1 © © NOUN admet-2089 348 2 2023 2023 NUM admet-2089 348 3 by by ADP admet-2089 348 4 the the DET admet-2089 348 5 authors author NOUN admet-2089 348 6 ; ; PUNCT admet-2089 348 7 licensee licensee PROPN admet-2089 348 8 iapc iapc PROPN admet-2089 348 9 , , PUNCT admet-2089 348 10 zagreb zagreb PROPN admet-2089 348 11 , , PUNCT admet-2089 348 12 croatia croatia PROPN admet-2089 348 13 . . PUNCT admet-2089 349 1 this this DET admet-2089 349 2 article article NOUN admet-2089 349 3 is be AUX admet-2089 349 4 an an DET admet-2089 349 5 open open ADJ admet-2089 349 6 - - PUNCT admet-2089 349 7 access access NOUN admet-2089 349 8 article article NOUN admet-2089 349 9 distributed distribute VERB admet-2089 349 10 under under ADP admet-2089 349 11 the the DET admet-2089 349 12 terms term NOUN admet-2089 349 13 and and CCONJ admet-2089 349 14 conditions condition NOUN admet-2089 349 15 of of ADP admet-2089 349 16 the the DET admet-2089 349 17 creative creative ADJ admet-2089 349 18 commons common NOUN admet-2089 349 19 attribution attribution NOUN admet-2089 349 20 license license NOUN admet-2089 349 21 ( ( PUNCT admet-2089 349 22 http://creativecommons.org/licenses/by/3.0/ http://creativecommons.org/licenses/by/3.0/ PROPN admet-2089 349 23 ) ) PUNCT admet-2089 349 24 https://doi.org/10.5599/admet.2089 https://doi.org/10.5599/admet.2089 NOUN admet-2089 349 25 http://paperpile.com/b/plxgz5/oxffy http://paperpile.com/b/plxgz5/oxffy PROPN admet-2089 349 26 http://paperpile.com/b/plxgz5/oxffy http://paperpile.com/b/plxgz5/oxffy PROPN admet-2089 349 27 http://dx.doi.org/10.1002/prot.21078 http://dx.doi.org/10.1002/prot.21078 PROPN admet-2089 349 28 http://paperpile.com/b/plxgz5/1ctic http://paperpile.com/b/plxgz5/1ctic PROPN admet-2089 349 29 http://paperpile.com/b/plxgz5/1ctic http://paperpile.com/b/plxgz5/1ctic PROPN admet-2089 349 30 http://dx.doi.org/10.1186/1471-2105-8-4 http://dx.doi.org/10.1186/1471-2105-8-4 PROPN admet-2089 349 31 http://paperpile.com/b/plxgz5/gidq9 http://paperpile.com/b/plxgz5/gidq9 PROPN admet-2089 349 32 http://paperpile.com/b/plxgz5/gidq9 http://paperpile.com/b/plxgz5/gidq9 PROPN admet-2089 349 33 http://dx.doi.org/10.1093/bioinformatics/btt619 http://dx.doi.org/10.1093/bioinformatics/btt619 PROPN admet-2089 350 1 http://paperpile.com/b/plxgz5/jlery http://paperpile.com/b/plxgz5/jlery PROPN admet-2089 350 2 http://paperpile.com/b/plxgz5/jlery http://paperpile.com/b/plxgz5/jlery PROPN admet-2089 350 3 http://paperpile.com/b/plxgz5/jlery http://paperpile.com/b/plxgz5/jlery PROPN admet-2089 350 4 http://dx.doi.org/10.1093/bib/bbab423 http://dx.doi.org/10.1093/bib/bbab423 PROPN admet-2089 350 5 http://paperpile.com/b/plxgz5/pik2 http://paperpile.com/b/plxgz5/pik2 PROPN admet-2089 350 6 http://paperpile.com/b/plxgz5/pik2 http://paperpile.com/b/plxgz5/pik2 PROPN admet-2089 350 7 http://paperpile.com/b/plxgz5/pik2 http://paperpile.com/b/plxgz5/pik2 PROPN admet-2089 350 8 http://paperpile.com/b/plxgz5/pik2 http://paperpile.com/b/plxgz5/pik2 PROPN admet-2089 350 9 http://paperpile.com/b/plxgz5/pik2 http://paperpile.com/b/plxgz5/pik2 PROPN admet-2089 350 10 http://paperpile.com/b/plxgz5/pik2 http://paperpile.com/b/plxgz5/pik2 PROPN admet-2089 350 11 http://paperpile.com/b/plxgz5/pik2 http://paperpile.com/b/plxgz5/pik2 PROPN admet-2089 350 12 http://dx.doi.org/10.1110/ps.0239403 http://dx.doi.org/10.1110/ps.0239403 PROPN admet-2089 350 13 http://paperpile.com/b/plxgz5/njp7 http://paperpile.com/b/plxgz5/njp7 PROPN admet-2089 350 14 http://paperpile.com/b/plxgz5/njp7 http://paperpile.com/b/plxgz5/njp7 PROPN admet-2089 350 15 http://paperpile.com/b/plxgz5/njp7 http://paperpile.com/b/plxgz5/njp7 PROPN admet-2089 350 16 http://paperpile.com/b/plxgz5/njp7 http://paperpile.com/b/plxgz5/njp7 PROPN admet-2089 350 17 http://paperpile.com/b/plxgz5/njp7 http://paperpile.com/b/plxgz5/njp7 PROPN admet-2089 350 18 http://paperpile.com/b/plxgz5/njp7 http://paperpile.com/b/plxgz5/njp7 PROPN admet-2089 350 19 http://paperpile.com/b/plxgz5/njp7 http://paperpile.com/b/plxgz5/njp7 PROPN admet-2089 350 20 http://dx.doi.org/10.1111/imm.12889 http://dx.doi.org/10.1111/imm.12889 NOUN admet-2089 350 21 http://paperpile.com/b/plxgz5/yygnz http://paperpile.com/b/plxgz5/yygnz PROPN admet-2089 350 22 http://paperpile.com/b/plxgz5/yygnz http://paperpile.com/b/plxgz5/yygnz PROPN admet-2089 350 23 http://paperpile.com/b/plxgz5/yygnz http://paperpile.com/b/plxgz5/yygnz PROPN admet-2089 350 24 http://dx.doi.org/10.1371/journal.pone.0009862 http://dx.doi.org/10.1371/journal.pone.0009862 PROPN admet-2089 350 25 http://paperpile.com/b/plxgz5/8py2j http://paperpile.com/b/plxgz5/8py2j NOUN admet-2089 350 26 https://play.google.com/store/books/details?id=ln3jbwaaqbaj https://play.google.com/store/books/details?id=ln3jbwaaqbaj NOUN admet-2089 350 27 https://link.springer.com/book/10.1007/978-1-4615-7422-4 https://link.springer.com/book/10.1007/978-1-4615-7422-4 PROPN admet-2089 350 28 http://paperpile.com/b/plxgz5/diyvn http://paperpile.com/b/plxgz5/diyvn PROPN admet-2089 350 29 http://paperpile.com/b/plxgz5/diyvn http://paperpile.com/b/plxgz5/diyvn PROPN admet-2089 350 30 http://dx.doi.org/10.1016/j.carbpol.2014.04.038 http://dx.doi.org/10.1016/j.carbpol.2014.04.038 PROPN admet-2089 350 31 http://paperpile.com/b/plxgz5/zgfmz http://paperpile.com/b/plxgz5/zgfmz VERB admet-2089 350 32 http://paperpile.com/b/plxgz5/zgfmz http://paperpile.com/b/plxgz5/zgfmz VERB admet-2089 350 33 http://paperpile.com/b/plxgz5/zgfmz http://paperpile.com/b/plxgz5/zgfmz NOUN admet-2089 350 34 http://paperpile.com/b/plxgz5/zgfmz http://paperpile.com/b/plxgz5/zgfmz NOUN admet-2089 350 35 http://dx.doi.org/10.1166/jnn.2013.7766 http://dx.doi.org/10.1166/jnn.2013.7766 ADP admet-2089 350 36 http://paperpile.com/b/plxgz5/dsll6 http://paperpile.com/b/plxgz5/dsll6 NOUN admet-2089 350 37 http://paperpile.com/b/plxgz5/dsll6 http://paperpile.com/b/plxgz5/dsll6 NOUN admet-2089 350 38 http://paperpile.com/b/plxgz5/dsll6 http://paperpile.com/b/plxgz5/dsll6 NOUN admet-2089 350 39 http://dx.doi.org/10.1016/s0168-3659(00)00240-6 http://dx.doi.org/10.1016/s0168-3659(00)00240-6 PROPN admet-2089 350 40 http://paperpile.com/b/plxgz5/hksot http://paperpile.com/b/plxgz5/hksot ADJ admet-2089 350 41 http://paperpile.com/b/plxgz5/hksot http://paperpile.com/b/plxgz5/hksot ADJ admet-2089 350 42 http://dx.doi.org/10.1016/0304-4157(76)90002-2 http://dx.doi.org/10.1016/0304-4157(76)90002-2 NOUN admet-2089 350 43 http://paperpile.com/b/plxgz5/nou41 http://paperpile.com/b/plxgz5/nou41 PROPN admet-2089 351 1 http://paperpile.com/b/plxgz5/nou41 http://paperpile.com/b/plxgz5/nou41 ADJ admet-2089 351 2 http://dx.doi.org/10.1080/08982100802636434 http://dx.doi.org/10.1080/08982100802636434 INTJ admet-2089 352 1 http://paperpile.com/b/plxgz5/6kfn http://paperpile.com/b/plxgz5/6kfn INTJ admet-2089 352 2 http://paperpile.com/b/plxgz5/6kfn http://paperpile.com/b/plxgz5/6kfn PROPN admet-2089 352 3 http://paperpile.com/b/plxgz5/6kfn http://paperpile.com/b/plxgz5/6kfn PROPN admet-2089 352 4 http://dx.doi.org/10.1016/s0928-8244(03)00176-7 http://dx.doi.org/10.1016/s0928-8244(03)00176-7 PROPN admet-2089 352 5 http://dx.doi.org/10.1016/s0928-8244(03)00176-7 http://dx.doi.org/10.1016/s0928-8244(03)00176-7 PROPN admet-2089 352 6 http://paperpile.com/b/plxgz5/wbnb http://paperpile.com/b/plxgz5/wbnb NOUN admet-2089 352 7 http://paperpile.com/b/plxgz5/wbnb http://paperpile.com/b/plxgz5/wbnb NOUN admet-2089 352 8 http://paperpile.com/b/plxgz5/wbnb http://paperpile.com/b/plxgz5/wbnb NOUN admet-2089 352 9 http://paperpile.com/b/plxgz5/wbnb http://paperpile.com/b/plxgz5/wbnb NOUN admet-2089 353 1 http://dx.doi.org/10.1016/j.meegid.2020.104462 http://dx.doi.org/10.1016/j.meegid.2020.104462 X admet-2089 353 2 http://creativecommons.org/licenses/by/3.0/ http://creativecommons.org/licenses/by/3.0/ NOUN