id	sid	tid	token	lemma	pos
admet-210	1	1	doi	doi	NOUN
admet-210	1	2	:	:	PUNCT
admet-210	1	3	10.5599	10.5599	NUM
admet-210	1	4	/	/	SYM
admet-210	1	5	admet.2.4.210	admet.2.4.210	PROPN
admet-210	1	6	84	84	NUM
admet-210	1	7	admet	admet	X
admet-210	1	8	&	&	CCONJ
admet-210	1	9	dmpk	dmpk	PROPN
admet-210	1	10	4(2	4(2	NUM
admet-210	1	11	)	)	PUNCT
admet-210	1	12	(	(	PUNCT
admet-210	1	13	2016	2016	NUM
admet-210	1	14	)	)	PUNCT
admet-210	1	15	84	84	NUM
admet-210	1	16	-	-	SYM
admet-210	1	17	90	90	NUM
admet-210	1	18	;	;	PUNCT
admet-210	1	19	doi	doi	NOUN
admet-210	1	20	:	:	PUNCT
admet-210	1	21	10.5599	10.5599	NUM
admet-210	1	22	/	/	SYM
admet-210	1	23	admet.4.2.210	admet.4.2.210	NOUN
admet-210	1	24	open	open	ADJ
admet-210	1	25	access	access	NOUN
admet-210	1	26	:	:	PUNCT
admet-210	1	27	issn	issn	PROPN
admet-210	1	28	:	:	PUNCT
admet-210	1	29	1848	1848	NUM
admet-210	1	30	-	-	SYM
admet-210	1	31	7718	7718	NUM
admet-210	1	32	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-210	1	33	short	short	ADJ
admet-210	1	34	communication	communication	NOUN
admet-210	1	35	metabolism	metabolism	NOUN
admet-210	1	36	of	of	ADP
admet-210	1	37	six	six	NUM
admet-210	1	38	cyp	cyp	ADJ
admet-210	1	39	probe	probe	NOUN
admet-210	1	40	substrates	substrate	NOUN
admet-210	1	41	in	in	ADP
admet-210	1	42	fetal	fetal	ADJ
admet-210	1	43	hepatocytes	hepatocyte	NOUN
admet-210	1	44	abdul	abdul	PROPN
admet-210	1	45	naveed	naveed	PROPN
admet-210	1	46	shaik*1,2	shaik*1,2	PROPN
admet-210	1	47	,	,	PUNCT
admet-210	1	48	sandeep	sandeep	PROPN
admet-210	1	49	kumar	kumar	PROPN
admet-210	1	50	vishwakarma1	vishwakarma1	PROPN
admet-210	1	51	and	and	CCONJ
admet-210	1	52	aleem	aleem	PROPN
admet-210	1	53	ahmed	ahme	VERB
admet-210	1	54	khan1	khan1	PROPN
admet-210	1	55	1	1	NUM
admet-210	1	56	center	center	NOUN
admet-210	1	57	for	for	ADP
admet-210	1	58	liver	liver	NOUN
admet-210	1	59	research	research	NOUN
admet-210	1	60	and	and	CCONJ
admet-210	1	61	diagnostics	diagnostic	NOUN
admet-210	1	62	,	,	PUNCT
admet-210	1	63	owaisi	owaisi	ADJ
admet-210	1	64	research	research	NOUN
admet-210	1	65	center	center	NOUN
admet-210	1	66	,	,	PUNCT
admet-210	1	67	deccan	deccan	PROPN
admet-210	1	68	college	college	PROPN
admet-210	1	69	of	of	ADP
admet-210	1	70	medical	medical	ADJ
admet-210	1	71	sciences	sciences	PROPN
admet-210	1	72	,	,	PUNCT
admet-210	1	73	hyderabad	hyderabad	PROPN
admet-210	1	74	,	,	PUNCT
admet-210	1	75	ts	ts	PROPN
admet-210	1	76	,	,	PUNCT
admet-210	1	77	india	india	PROPN
admet-210	1	78	2	2	NUM
admet-210	1	79	department	department	NOUN
admet-210	1	80	of	of	ADP
admet-210	1	81	pharmaceutical	pharmaceutical	NOUN
admet-210	1	82	sciences	science	NOUN
admet-210	1	83	,	,	PUNCT
admet-210	1	84	mcphs	mcph	NOUN
admet-210	1	85	university	university	PROPN
admet-210	1	86	,	,	PUNCT
admet-210	1	87	boston	boston	PROPN
admet-210	1	88	ma	ma	PROPN
admet-210	1	89	,	,	PUNCT
admet-210	1	90	usa	usa	PROPN
admet-210	1	91	*	*	PUNCT
admet-210	1	92	corresponding	correspond	VERB
admet-210	1	93	author	author	NOUN
admet-210	1	94	.	.	PUNCT
admet-210	2	1	e	e	X
admet-210	2	2	-	-	NOUN
admet-210	2	3	mail	mail	NOUN
admet-210	2	4	:	:	PUNCT
admet-210	2	5	naveedshaik@gmail.com	naveedshaik@gmail.com	NUM
admet-210	2	6	;	;	PUNCT
admet-210	2	7	tel	tel	PROPN
admet-210	2	8	.	.	PUNCT
admet-210	2	9	:	:	PUNCT
admet-210	3	1	+1	+1	ADJ
admet-210	3	2	-	-	PUNCT
admet-210	3	3	407	407	NUM
admet-210	3	4	-	-	PUNCT
admet-210	3	5	303	303	NUM
admet-210	3	6	-	-	SYM
admet-210	3	7	7003	7003	NUM
admet-210	3	8	;	;	PUNCT
admet-210	3	9	fax	fax	NOUN
admet-210	3	10	:	:	PUNCT
admet-210	3	11	+1	+1	ADJ
admet-210	3	12	-	-	PUNCT
admet-210	3	13	407	407	NUM
admet-210	3	14	-	-	PUNCT
admet-210	3	15	303	303	NUM
admet-210	3	16	-	-	SYM
admet-210	3	17	7030	7030	NUM
admet-210	3	18	received	receive	VERB
admet-210	3	19	:	:	PUNCT
admet-210	3	20	august	august	PROPN
admet-210	3	21	12	12	NUM
admet-210	3	22	,	,	PUNCT
admet-210	3	23	2016	2016	NUM
admet-210	3	24	;	;	PUNCT
admet-210	3	25	revised	revise	VERB
admet-210	3	26	:	:	PUNCT
admet-210	3	27	october	october	PROPN
admet-210	3	28	02	02	NUM
admet-210	3	29	,	,	PUNCT
admet-210	3	30	2016	2016	NUM
admet-210	3	31	;	;	PUNCT
admet-210	3	32	published	publish	VERB
admet-210	3	33	:	:	PUNCT
admet-210	3	34	june	june	PROPN
admet-210	3	35	29	29	NUM
admet-210	3	36	,	,	PUNCT
admet-210	3	37	2016	2016	NUM
admet-210	3	38	abstract	abstract	ADJ
admet-210	3	39	cytochrome	cytochrome	NOUN
admet-210	3	40	p-450	p-450	PROPN
admet-210	3	41	(	(	PUNCT
admet-210	3	42	cyp	cyp	ADJ
admet-210	3	43	)	)	PUNCT
admet-210	3	44	are	be	AUX
admet-210	3	45	the	the	DET
admet-210	3	46	most	most	ADV
admet-210	3	47	common	common	ADJ
admet-210	3	48	drug	drug	NOUN
admet-210	3	49	metabolizing	metabolize	VERB
admet-210	3	50	enzymes	enzyme	NOUN
admet-210	3	51	and	and	CCONJ
admet-210	3	52	are	be	AUX
admet-210	3	53	abundantly	abundantly	ADV
admet-210	3	54	expressed	express	VERB
admet-210	3	55	in	in	ADP
admet-210	3	56	liver	liver	NOUN
admet-210	3	57	apart	apart	ADV
admet-210	3	58	from	from	ADP
admet-210	3	59	kidney	kidney	NOUN
admet-210	3	60	,	,	PUNCT
admet-210	3	61	lungs	lung	NOUN
admet-210	3	62	,	,	PUNCT
admet-210	3	63	intestine	intestine	NOUN
admet-210	3	64	,	,	PUNCT
admet-210	3	65	brain	brain	NOUN
admet-210	3	66	etc	etc	X
admet-210	3	67	.	.	PUNCT
admet-210	4	1	their	their	PRON
admet-210	4	2	expression	expression	NOUN
admet-210	4	3	levels	level	NOUN
admet-210	4	4	change	change	VERB
admet-210	4	5	with	with	ADP
admet-210	4	6	physiological	physiological	ADJ
admet-210	4	7	conditions	condition	NOUN
admet-210	4	8	and	and	CCONJ
admet-210	4	9	disease	disease	NOUN
admet-210	4	10	states	state	NOUN
admet-210	4	11	.	.	PUNCT
admet-210	5	1	the	the	DET
admet-210	5	2	expression	expression	NOUN
admet-210	5	3	of	of	ADP
admet-210	5	4	these	these	DET
admet-210	5	5	cyps	cyps	NOUN
admet-210	5	6	is	be	AUX
admet-210	5	7	less	less	ADJ
admet-210	5	8	in	in	ADP
admet-210	5	9	human	human	ADJ
admet-210	5	10	foetus	foetus	NOUN
admet-210	5	11	and	and	CCONJ
admet-210	5	12	neonates	neonate	NOUN
admet-210	5	13	compared	compare	VERB
admet-210	5	14	to	to	ADP
admet-210	5	15	adults	adult	NOUN
admet-210	5	16	,	,	PUNCT
admet-210	5	17	which	which	PRON
admet-210	5	18	results	result	VERB
admet-210	5	19	in	in	ADP
admet-210	5	20	lower	low	ADJ
admet-210	5	21	clearance	clearance	NOUN
admet-210	5	22	of	of	ADP
admet-210	5	23	xenobiotics	xenobiotic	NOUN
admet-210	5	24	in	in	ADP
admet-210	5	25	infants	infant	NOUN
admet-210	5	26	and	and	CCONJ
admet-210	5	27	neonates	neonate	NOUN
admet-210	5	28	compared	compare	VERB
admet-210	5	29	to	to	ADP
admet-210	5	30	adults	adult	NOUN
admet-210	5	31	.	.	PUNCT
admet-210	6	1	hepatocytes	hepatocytes	PROPN
admet-210	6	2	are	be	AUX
admet-210	6	3	the	the	DET
admet-210	6	4	cells	cell	NOUN
admet-210	6	5	which	which	PRON
admet-210	6	6	are	be	AUX
admet-210	6	7	largely	largely	ADV
admet-210	6	8	used	use	VERB
admet-210	6	9	to	to	PART
admet-210	6	10	study	study	VERB
admet-210	6	11	these	these	DET
admet-210	6	12	cyps	cyp	NOUN
admet-210	6	13	.	.	PUNCT
admet-210	7	1	we	we	PRON
admet-210	7	2	have	have	AUX
admet-210	7	3	isolated	isolate	VERB
admet-210	7	4	hepatocytes	hepatocyte	NOUN
admet-210	7	5	from	from	ADP
admet-210	7	6	aborted	aborted	ADJ
admet-210	7	7	foetus	foetus	NOUN
admet-210	7	8	to	to	PART
admet-210	7	9	study	study	VERB
admet-210	7	10	the	the	DET
admet-210	7	11	metabolism	metabolism	NOUN
admet-210	7	12	of	of	ADP
admet-210	7	13	six	six	NUM
admet-210	7	14	probe	probe	NOUN
admet-210	7	15	substrates	substrate	NOUN
admet-210	7	16	:	:	PUNCT
admet-210	7	17	phenacetin	phenacetin	NOUN
admet-210	7	18	,	,	PUNCT
admet-210	7	19	diclofenac	diclofenac	NOUN
admet-210	7	20	,	,	PUNCT
admet-210	7	21	s	s	NOUN
admet-210	7	22	-	-	PUNCT
admet-210	7	23	mephenytoin	mephenytoin	ADJ
admet-210	7	24	,	,	PUNCT
admet-210	7	25	dextromethorphan	dextromethorphan	PROPN
admet-210	7	26	,	,	PUNCT
admet-210	7	27	nifedipine	nifedipine	NOUN
admet-210	7	28	and	and	CCONJ
admet-210	7	29	testosterone	testosterone	NOUN
admet-210	7	30	.	.	PUNCT
admet-210	8	1	the	the	DET
admet-210	8	2	results	result	NOUN
admet-210	8	3	obtained	obtain	VERB
admet-210	8	4	show	show	VERB
admet-210	8	5	the	the	DET
admet-210	8	6	expression	expression	NOUN
admet-210	8	7	of	of	ADP
admet-210	8	8	various	various	ADJ
admet-210	8	9	cyps	cyps	PROPN
admet-210	8	10	(	(	PUNCT
admet-210	8	11	cyp1a2	cyp1a2	PROPN
admet-210	8	12	,	,	PUNCT
admet-210	8	13	cyp2c19	cyp2c19	PROPN
admet-210	8	14	,	,	PUNCT
admet-210	8	15	cyp2c9	cyp2c9	NOUN
admet-210	8	16	,	,	PUNCT
admet-210	8	17	cyp2d6	cyp2d6	NOUN
admet-210	8	18	,	,	PUNCT
admet-210	8	19	and	and	CCONJ
admet-210	8	20	cyp3a4	cyp3a4	PROPN
admet-210	8	21	)	)	PUNCT
admet-210	8	22	in	in	ADP
admet-210	8	23	human	human	ADJ
admet-210	8	24	foetus	foetus	NOUN
admet-210	8	25	and	and	CCONJ
admet-210	8	26	their	their	PRON
admet-210	8	27	involvement	involvement	NOUN
admet-210	8	28	in	in	ADP
admet-210	8	29	metabolism	metabolism	NOUN
admet-210	8	30	of	of	ADP
admet-210	8	31	cyp	cyp	ADJ
admet-210	8	32	probe	probe	NOUN
admet-210	8	33	substrates	substrate	NOUN
admet-210	8	34	.	.	PUNCT
admet-210	9	1	keywords	keyword	VERB
admet-210	9	2	fetal	fetal	ADJ
admet-210	9	3	metabolism	metabolism	NOUN
admet-210	9	4	;	;	PUNCT
admet-210	9	5	cyp	cyp	ADJ
admet-210	9	6	(	(	PUNCT
admet-210	9	7	cytochrome	cytochrome	NOUN
admet-210	9	8	-	-	PUNCT
admet-210	9	9	p450	p450	NUM
admet-210	9	10	)	)	PUNCT
admet-210	9	11	;	;	PUNCT
admet-210	9	12	hepatocytes	hepatocytes	PROPN
admet-210	9	13	;	;	PUNCT
admet-210	9	14	metabolic	metabolic	NOUN
admet-210	9	15	stability	stability	NOUN
admet-210	9	16	;	;	PUNCT
admet-210	9	17	hplc	hplc	NOUN
admet-210	9	18	;	;	PUNCT
admet-210	9	19	dextromethorphan	dextromethorphan	PROPN
admet-210	9	20	;	;	PUNCT
admet-210	9	21	diclofenac	diclofenac	NOUN
admet-210	9	22	;	;	PUNCT
admet-210	9	23	s	s	X
admet-210	9	24	-	-	PUNCT
admet-210	9	25	mephenytoin	mephenytoin	NOUN
admet-210	9	26	;	;	PUNCT
admet-210	9	27	nifedipine	nifedipine	NOUN
admet-210	9	28	;	;	PUNCT
admet-210	9	29	testosterone	testosterone	NOUN
admet-210	9	30	.	.	PUNCT
admet-210	10	1	introduction	introduction	NOUN
admet-210	10	2	the	the	DET
admet-210	10	3	role	role	NOUN
admet-210	10	4	of	of	ADP
admet-210	10	5	cytochromes	cytochrome	NOUN
admet-210	10	6	p450	p450	PROPN
admet-210	10	7	(	(	PUNCT
admet-210	10	8	cyp	cyp	ADJ
admet-210	10	9	)	)	PUNCT
admet-210	10	10	mediated	mediate	VERB
admet-210	10	11	metabolism	metabolism	NOUN
admet-210	10	12	is	be	AUX
admet-210	10	13	well	well	ADV
admet-210	10	14	appreciated	appreciated	ADJ
admet-210	10	15	in	in	ADP
admet-210	10	16	the	the	DET
admet-210	10	17	drug	drug	NOUN
admet-210	10	18	discovery	discovery	NOUN
admet-210	10	19	setup	setup	NOUN
admet-210	10	20	,	,	PUNCT
admet-210	10	21	over	over	ADP
admet-210	10	22	the	the	DET
admet-210	10	23	last	last	ADJ
admet-210	10	24	few	few	ADJ
admet-210	10	25	decades	decade	NOUN
admet-210	10	26	much	much	ADJ
admet-210	10	27	emphasis	emphasis	NOUN
admet-210	10	28	has	have	AUX
admet-210	10	29	been	be	AUX
admet-210	10	30	laid	lay	VERB
admet-210	10	31	on	on	ADP
admet-210	10	32	how	how	SCONJ
admet-210	10	33	different	different	ADJ
admet-210	10	34	drugs	drug	NOUN
admet-210	10	35	are	be	AUX
admet-210	10	36	handled	handle	VERB
admet-210	10	37	by	by	ADP
admet-210	10	38	the	the	DET
admet-210	10	39	cyps	cyps	PROPN
admet-210	10	40	.	.	PUNCT
admet-210	11	1	cyps	cyps	PROPN
admet-210	11	2	are	be	AUX
admet-210	11	3	one	one	NUM
admet-210	11	4	of	of	ADP
admet-210	11	5	the	the	DET
admet-210	11	6	major	major	ADJ
admet-210	11	7	source	source	NOUN
admet-210	11	8	of	of	ADP
admet-210	11	9	variability	variability	NOUN
admet-210	11	10	in	in	ADP
admet-210	11	11	pharmacokinetics	pharmacokinetic	NOUN
admet-210	11	12	(	(	PUNCT
admet-210	11	13	pk	pk	NOUN
admet-210	11	14	)	)	PUNCT
admet-210	11	15	and	and	CCONJ
admet-210	11	16	pharmacodynamics	pharmacodynamic	NOUN
admet-210	11	17	(	(	PUNCT
admet-210	11	18	pd	pd	NOUN
admet-210	11	19	)	)	PUNCT
admet-210	11	20	of	of	ADP
admet-210	11	21	the	the	DET
admet-210	11	22	drugs	drug	NOUN
admet-210	11	23	[	[	X
admet-210	11	24	1	1	NUM
admet-210	11	25	]	]	PUNCT
admet-210	11	26	.	.	PUNCT
admet-210	12	1	the	the	DET
admet-210	12	2	cyps	cyps	PROPN
admet-210	12	3	are	be	AUX
admet-210	12	4	widely	widely	ADV
admet-210	12	5	distributed	distribute	VERB
admet-210	12	6	and	and	CCONJ
admet-210	12	7	expressed	express	VERB
admet-210	12	8	in	in	ADP
admet-210	12	9	different	different	ADJ
admet-210	12	10	organs	organ	NOUN
admet-210	12	11	including	include	VERB
admet-210	12	12	,	,	PUNCT
admet-210	12	13	liver	liver	NOUN
admet-210	12	14	,	,	PUNCT
admet-210	12	15	intestine	intestine	NOUN
admet-210	12	16	,	,	PUNCT
admet-210	12	17	lungs	lung	NOUN
admet-210	12	18	,	,	PUNCT
admet-210	12	19	kidney	kidney	NOUN
admet-210	12	20	,	,	PUNCT
admet-210	12	21	placenta	placenta	NOUN
admet-210	12	22	,	,	PUNCT
admet-210	12	23	brain	brain	NOUN
admet-210	12	24	etc	etc	X
admet-210	12	25	.	.	PUNCT
admet-210	13	1	the	the	DET
admet-210	13	2	highest	high	ADJ
admet-210	13	3	expression	expression	NOUN
admet-210	13	4	levels	level	NOUN
admet-210	13	5	are	be	AUX
admet-210	13	6	observed	observe	VERB
admet-210	13	7	in	in	ADP
admet-210	13	8	liver	liver	NOUN
admet-210	13	9	,	,	PUNCT
admet-210	13	10	and	and	CCONJ
admet-210	13	11	the	the	DET
admet-210	13	12	major	major	ADJ
admet-210	13	13	ones	one	NOUN
admet-210	13	14	to	to	PART
admet-210	13	15	be	be	AUX
admet-210	13	16	expressed	express	VERB
admet-210	13	17	in	in	ADP
admet-210	13	18	liver	liver	NOUN
admet-210	13	19	are	be	AUX
admet-210	13	20	cyps	cyps	PROPN
admet-210	13	21	3a4	3a4	NUM
admet-210	13	22	,	,	PUNCT
admet-210	13	23	2c9	2c9	NUM
admet-210	13	24	,	,	PUNCT
admet-210	13	25	2c8	2c8	NUM
admet-210	13	26	,	,	PUNCT
admet-210	13	27	2e1	2e1	NUM
admet-210	13	28	,	,	PUNCT
admet-210	13	29	and	and	CCONJ
admet-210	14	1	1a2	1a2	NUM
admet-210	15	1	[	[	X
admet-210	15	2	2	2	NUM
admet-210	15	3	]	]	PUNCT
admet-210	15	4	.	.	PUNCT
admet-210	16	1	these	these	DET
admet-210	16	2	five	five	NUM
admet-210	16	3	isoforms	isoform	NOUN
admet-210	16	4	are	be	AUX
admet-210	16	5	responsible	responsible	ADJ
admet-210	16	6	for	for	ADP
admet-210	16	7	the	the	DET
admet-210	16	8	biotransformation	biotransformation	NOUN
admet-210	16	9	of	of	ADP
admet-210	16	10	many	many	ADJ
admet-210	16	11	of	of	ADP
admet-210	16	12	the	the	DET
admet-210	16	13	drugs	drug	NOUN
admet-210	16	14	in	in	ADP
admet-210	16	15	market	market	NOUN
admet-210	16	16	which	which	PRON
admet-210	16	17	makes	make	VERB
admet-210	16	18	up	up	ADP
admet-210	16	19	to	to	PART
admet-210	16	20	80	80	NUM
admet-210	16	21	%	%	NOUN
admet-210	16	22	of	of	ADP
admet-210	16	23	the	the	DET
admet-210	16	24	total	total	ADJ
admet-210	16	25	drugs	drug	NOUN
admet-210	16	26	in	in	ADP
admet-210	16	27	clinical	clinical	ADJ
admet-210	16	28	use	use	NOUN
admet-210	16	29	.	.	PUNCT
admet-210	17	1	expression	expression	NOUN
admet-210	17	2	of	of	ADP
admet-210	17	3	these	these	DET
admet-210	17	4	cyp	cyp	ADJ
admet-210	17	5	enzymes	enzyme	NOUN
admet-210	17	6	depends	depend	VERB
admet-210	17	7	on	on	ADP
admet-210	17	8	varied	varied	ADJ
admet-210	17	9	factors	factor	NOUN
admet-210	17	10	including	include	VERB
admet-210	17	11	sex	sex	NOUN
admet-210	17	12	,	,	PUNCT
admet-210	17	13	age	age	NOUN
admet-210	17	14	,	,	PUNCT
admet-210	17	15	disease	disease	NOUN
admet-210	17	16	states	state	NOUN
admet-210	17	17	,	,	PUNCT
admet-210	17	18	etc	etc	X
admet-210	17	19	[	[	X
admet-210	17	20	3	3	NUM
admet-210	17	21	]	]	PUNCT
admet-210	17	22	.	.	PUNCT
admet-210	18	1	the	the	DET
admet-210	18	2	mechanism	mechanism	NOUN
admet-210	18	3	of	of	ADP
admet-210	18	4	these	these	DET
admet-210	18	5	cyp	cyp	ADJ
admet-210	18	6	isoforms	isoform	NOUN
admet-210	18	7	and	and	CCONJ
admet-210	18	8	their	their	PRON
admet-210	18	9	contribution	contribution	NOUN
admet-210	18	10	towards	towards	ADP
admet-210	18	11	drug	drug	NOUN
admet-210	18	12	-	-	PUNCT
admet-210	18	13	drug	drug	NOUN
admet-210	18	14	interactions	interaction	NOUN
admet-210	18	15	leading	lead	VERB
admet-210	18	16	to	to	ADP
admet-210	18	17	either	either	DET
admet-210	18	18	changes	change	NOUN
admet-210	18	19	in	in	ADP
admet-210	18	20	label	label	NOUN
admet-210	18	21	or	or	CCONJ
admet-210	18	22	complete	complete	ADJ
admet-210	18	23	withdrawal	withdrawal	NOUN
admet-210	18	24	from	from	ADP
admet-210	18	25	the	the	DET
admet-210	18	26	market	market	NOUN
admet-210	18	27	has	have	AUX
admet-210	18	28	been	be	AUX
admet-210	18	29	well	well	ADV
admet-210	18	30	understood	understand	VERB
admet-210	18	31	[	[	X
admet-210	18	32	4	4	NUM
admet-210	18	33	]	]	PUNCT
admet-210	18	34	.	.	PUNCT
admet-210	19	1	even	even	ADV
admet-210	19	2	though	though	SCONJ
admet-210	19	3	thorough	thorough	ADJ
admet-210	19	4	investigations	investigation	NOUN
admet-210	19	5	of	of	ADP
admet-210	19	6	these	these	DET
admet-210	19	7	cyps	cyp	NOUN
admet-210	19	8	including	include	VERB
admet-210	19	9	their	their	PRON
admet-210	19	10	polymorphism	polymorphism	NOUN
admet-210	19	11	led	lead	VERB
admet-210	19	12	to	to	ADP
admet-210	19	13	relatively	relatively	ADV
admet-210	19	14	safer	safe	ADJ
admet-210	19	15	prescription	prescription	NOUN
admet-210	19	16	practices	practice	NOUN
admet-210	19	17	[	[	X
admet-210	19	18	5	5	NUM
admet-210	19	19	]	]	PUNCT
admet-210	19	20	,	,	PUNCT
admet-210	19	21	involvement	involvement	NOUN
admet-210	19	22	of	of	ADP
admet-210	19	23	fetal	fetal	ADJ
admet-210	19	24	metabolism	metabolism	NOUN
admet-210	19	25	still	still	ADV
admet-210	19	26	remains	remain	VERB
admet-210	19	27	highly	highly	ADV
admet-210	19	28	disparaged	disparage	VERB
admet-210	19	29	[	[	PUNCT
admet-210	19	30	6	6	NUM
admet-210	19	31	-	-	SYM
admet-210	19	32	9	9	NUM
admet-210	19	33	]	]	PUNCT
admet-210	19	34	.	.	PUNCT
admet-210	20	1	role	role	NOUN
admet-210	20	2	of	of	ADP
admet-210	20	3	cyp	cyp	ADJ
admet-210	20	4	enzymes	enzyme	NOUN
admet-210	20	5	in	in	ADP
admet-210	20	6	clearance	clearance	NOUN
admet-210	20	7	of	of	ADP
admet-210	20	8	drugs	drug	NOUN
admet-210	20	9	from	from	ADP
admet-210	20	10	foetus	foetus	NOUN
admet-210	20	11	and	and	CCONJ
admet-210	20	12	neonates	neonate	NOUN
admet-210	20	13	is	be	AUX
admet-210	20	14	explored	explore	VERB
admet-210	20	15	since	since	SCONJ
admet-210	20	16	early	early	ADJ
admet-210	20	17	70	70	NUM
admet-210	20	18	’s	’s	NOUN
admet-210	20	19	,	,	PUNCT
admet-210	20	20	but	but	CCONJ
admet-210	20	21	the	the	DET
admet-210	20	22	lack	lack	NOUN
admet-210	20	23	of	of	ADP
admet-210	20	24	microsomes	microsome	NOUN
admet-210	20	25	and	and	CCONJ
admet-210	20	26	hepatocytes	hepatocyte	NOUN
admet-210	20	27	of	of	ADP
admet-210	20	28	fetal	fetal	ADJ
admet-210	20	29	and	and	CCONJ
admet-210	20	30	neonatal	neonatal	ADJ
admet-210	20	31	origin	origin	NOUN
admet-210	20	32	has	have	AUX
admet-210	20	33	greatly	greatly	ADV
admet-210	20	34	limited	limit	VERB
admet-210	20	35	our	our	PRON
admet-210	20	36	understanding	understanding	NOUN
admet-210	20	37	of	of	ADP
admet-210	20	38	the	the	DET
admet-210	20	39	drug	drug	NOUN
admet-210	20	40	behaviour	behaviour	NOUN
admet-210	20	41	in	in	ADP
admet-210	20	42	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-210	20	43	mailto:naveedshaik@gmail.com	mailto:naveedshaik@gmail.com	PROPN
admet-210	21	1	admet	admet	PROPN
admet-210	21	2	&	&	CCONJ
admet-210	21	3	dmpk	dmpk	PROPN
admet-210	21	4	4(2	4(2	NUM
admet-210	21	5	)	)	PUNCT
admet-210	21	6	(	(	PUNCT
admet-210	21	7	2016	2016	NUM
admet-210	21	8	)	)	PUNCT
admet-210	21	9	84	84	NUM
admet-210	21	10	-	-	SYM
admet-210	21	11	90	90	NUM
admet-210	21	12	cyp	cyp	ADJ
admet-210	21	13	substrates	substrate	NOUN
admet-210	21	14	in	in	ADP
admet-210	21	15	fetal	fetal	ADJ
admet-210	21	16	hepatocytes	hepatocyte	NOUN
admet-210	21	17	doi	doi	NOUN
admet-210	21	18	:	:	PUNCT
admet-210	21	19	10.5599	10.5599	NUM
admet-210	21	20	/	/	SYM
admet-210	21	21	admet.4.2.210	admet.4.2.210	PROPN
admet-210	21	22	85	85	NUM
admet-210	21	23	foetus	foetus	NOUN
admet-210	21	24	and	and	CCONJ
admet-210	21	25	neonates	neonate	NOUN
admet-210	21	26	.	.	PUNCT
admet-210	22	1	furthermore	furthermore	ADV
admet-210	22	2	,	,	PUNCT
admet-210	22	3	lack	lack	NOUN
admet-210	22	4	of	of	ADP
admet-210	22	5	complete	complete	ADJ
admet-210	22	6	knowledge	knowledge	NOUN
admet-210	22	7	of	of	ADP
admet-210	22	8	adverse	adverse	ADJ
admet-210	22	9	events	event	NOUN
admet-210	22	10	related	relate	VERB
admet-210	22	11	to	to	ADP
admet-210	22	12	drugs	drug	NOUN
admet-210	22	13	and	and	CCONJ
admet-210	22	14	scant	scant	ADJ
admet-210	22	15	data	datum	NOUN
admet-210	22	16	of	of	ADP
admet-210	22	17	pk	pk	NOUN
admet-210	22	18	parameters	parameter	NOUN
admet-210	22	19	during	during	ADP
admet-210	22	20	pregnancy	pregnancy	NOUN
admet-210	22	21	leads	lead	VERB
admet-210	22	22	to	to	ADP
admet-210	22	23	either	either	CCONJ
admet-210	22	24	cautious	cautious	ADJ
admet-210	22	25	prescription	prescription	NOUN
admet-210	22	26	or	or	CCONJ
admet-210	22	27	complete	complete	ADJ
admet-210	22	28	avoidance	avoidance	NOUN
admet-210	22	29	of	of	ADP
admet-210	22	30	many	many	ADJ
admet-210	22	31	drugs	drug	NOUN
admet-210	22	32	[	[	X
admet-210	22	33	10	10	NUM
admet-210	22	34	-	-	SYM
admet-210	22	35	12	12	NUM
admet-210	22	36	]	]	PUNCT
admet-210	22	37	.	.	PUNCT
admet-210	23	1	advances	advance	NOUN
admet-210	23	2	in	in	ADP
admet-210	23	3	drug	drug	NOUN
admet-210	23	4	metabolism	metabolism	NOUN
admet-210	23	5	,	,	PUNCT
admet-210	23	6	drug	drug	NOUN
admet-210	23	7	transport	transport	NOUN
admet-210	23	8	and	and	CCONJ
admet-210	23	9	drug	drug	NOUN
admet-210	23	10	-	-	PUNCT
admet-210	23	11	drug	drug	NOUN
admet-210	23	12	interactions	interaction	NOUN
admet-210	23	13	in	in	ADP
admet-210	23	14	human	human	ADJ
admet-210	23	15	foetus	foetus	NOUN
admet-210	23	16	will	will	AUX
admet-210	23	17	greatly	greatly	ADV
admet-210	23	18	benefit	benefit	VERB
admet-210	23	19	the	the	DET
admet-210	23	20	patients	patient	NOUN
admet-210	23	21	and	and	CCONJ
admet-210	23	22	clinicians	clinician	NOUN
admet-210	23	23	alike	alike	ADV
admet-210	23	24	[	[	X
admet-210	23	25	13	13	NUM
admet-210	23	26	]	]	PUNCT
admet-210	23	27	.	.	PUNCT
admet-210	24	1	hepatocytes	hepatocytes	PROPN
admet-210	24	2	are	be	AUX
admet-210	24	3	considered	consider	VERB
admet-210	24	4	as	as	ADP
admet-210	24	5	one	one	NUM
admet-210	24	6	of	of	ADP
admet-210	24	7	the	the	DET
admet-210	24	8	better	well	ADJ
admet-210	24	9	in	in	ADP
admet-210	24	10	vitro	vitro	X
admet-210	24	11	tools	tool	NOUN
admet-210	24	12	to	to	PART
admet-210	24	13	study	study	VERB
admet-210	24	14	metabolism	metabolism	NOUN
admet-210	24	15	[	[	X
admet-210	24	16	14	14	NUM
admet-210	24	17	,	,	PUNCT
admet-210	24	18	15	15	NUM
admet-210	24	19	]	]	PUNCT
admet-210	24	20	,	,	PUNCT
admet-210	24	21	therefore	therefore	ADV
admet-210	24	22	we	we	PRON
admet-210	24	23	explored	explore	VERB
admet-210	24	24	the	the	DET
admet-210	24	25	metabolic	metabolic	NOUN
admet-210	24	26	stability	stability	NOUN
admet-210	24	27	of	of	ADP
admet-210	24	28	six	six	NUM
admet-210	24	29	probe	probe	NOUN
admet-210	24	30	substrates	substrate	NOUN
admet-210	24	31	:	:	PUNCT
admet-210	24	32	phenacetin	phenacetin	NOUN
admet-210	24	33	(	(	PUNCT
admet-210	24	34	cyp1a2	cyp1a2	NOUN
admet-210	24	35	)	)	PUNCT
admet-210	24	36	,	,	PUNCT
admet-210	24	37	diclofenac	diclofenac	NOUN
admet-210	24	38	(	(	PUNCT
admet-210	24	39	cyp2c9	cyp2c9	NOUN
admet-210	24	40	)	)	PUNCT
admet-210	24	41	,	,	PUNCT
admet-210	24	42	s	s	X
admet-210	24	43	-	-	X
admet-210	24	44	mephenytoin	mephenytoin	ADJ
admet-210	24	45	(	(	PUNCT
admet-210	24	46	cyp2c19	cyp2c19	PROPN
admet-210	24	47	)	)	PUNCT
admet-210	24	48	,	,	PUNCT
admet-210	24	49	dextromethorphan	dextromethorphan	PROPN
admet-210	24	50	(	(	PUNCT
admet-210	24	51	cyp2d6	cyp2d6	PROPN
admet-210	24	52	)	)	PUNCT
admet-210	24	53	,	,	PUNCT
admet-210	24	54	nifedipine	nifedipine	NOUN
admet-210	24	55	(	(	PUNCT
admet-210	24	56	cyp3a4	cyp3a4	PROPN
admet-210	24	57	)	)	PUNCT
admet-210	24	58	and	and	CCONJ
admet-210	24	59	testosterone	testosterone	NOUN
admet-210	24	60	(	(	PUNCT
admet-210	24	61	cyp3a4	cyp3a4	NOUN
admet-210	24	62	)	)	PUNCT
admet-210	24	63	in	in	ADP
admet-210	24	64	hepatocytes	hepatocyte	NOUN
admet-210	24	65	of	of	ADP
admet-210	24	66	fetal	fetal	ADJ
admet-210	24	67	origin	origin	NOUN
admet-210	25	1	[	[	X
admet-210	25	2	16	16	NUM
admet-210	25	3	]	]	PUNCT
admet-210	25	4	.	.	PUNCT
admet-210	26	1	experimental	experimental	ADJ
admet-210	26	2	chemicals	chemical	NOUN
admet-210	26	3	and	and	CCONJ
admet-210	26	4	reagents	reagent	NOUN
admet-210	26	5	diclofenac	diclofenac	NOUN
admet-210	26	6	,	,	PUNCT
admet-210	26	7	4	4	NUM
admet-210	26	8	-	-	PUNCT
admet-210	26	9	hydroxydiclofenac	hydroxydiclofenac	NOUN
admet-210	26	10	,	,	PUNCT
admet-210	26	11	dextromethorphan	dextromethorphan	PROPN
admet-210	26	12	,	,	PUNCT
admet-210	26	13	dextrorphan	dextrorphan	ADJ
admet-210	26	14	,	,	PUNCT
admet-210	26	15	phenacetin	phenacetin	NOUN
admet-210	26	16	,	,	PUNCT
admet-210	26	17	paracetamol	paracetamol	PROPN
admet-210	26	18	,	,	PUNCT
admet-210	26	19	smephenytoin	smephenytoin	PROPN
admet-210	26	20	,	,	PUNCT
admet-210	26	21	4	4	NUM
admet-210	26	22	-	-	PUNCT
admet-210	26	23	hydroxymephenytoin	hydroxymephenytoin	NOUN
admet-210	26	24	,	,	PUNCT
admet-210	26	25	nifedipine	nifedipine	NOUN
admet-210	26	26	,	,	PUNCT
admet-210	26	27	oxidized	oxidize	VERB
admet-210	26	28	nifedipine	nifedipine	NOUN
admet-210	26	29	,	,	PUNCT
admet-210	26	30	testosterone	testosterone	NOUN
admet-210	26	31	,	,	PUNCT
admet-210	26	32	6βhydroxytestosterone	6βhydroxytestosterone	NUM
admet-210	26	33	,	,	PUNCT
admet-210	26	34	celecoxib	celecoxib	X
admet-210	26	35	,	,	PUNCT
admet-210	26	36	dmso	dmso	NOUN
admet-210	26	37	(	(	PUNCT
admet-210	26	38	dimethyl	dimethyl	NOUN
admet-210	26	39	sulfoxide	sulfoxide	NOUN
admet-210	26	40	)	)	PUNCT
admet-210	26	41	,	,	PUNCT
admet-210	26	42	dmem	dmem	VERB
admet-210	26	43	(	(	PUNCT
admet-210	26	44	dulbecco	dulbecco	NOUN
admet-210	26	45	’s	’s	PART
admet-210	26	46	modified	modify	VERB
admet-210	26	47	eagles	eagle	NOUN
admet-210	26	48	medium	medium	ADJ
admet-210	26	49	)	)	PUNCT
admet-210	26	50	,	,	PUNCT
admet-210	26	51	pbs	pbs	PROPN
admet-210	26	52	(	(	PUNCT
admet-210	26	53	phosphate	phosphate	ADJ
admet-210	26	54	buffer	buffer	NOUN
admet-210	26	55	saline	saline	NOUN
admet-210	26	56	)	)	PUNCT
admet-210	26	57	were	be	AUX
admet-210	26	58	obtained	obtain	VERB
admet-210	26	59	from	from	ADP
admet-210	26	60	sigma	sigma	PROPN
admet-210	26	61	aldrich	aldrich	PROPN
admet-210	26	62	(	(	PUNCT
admet-210	26	63	st	st	PROPN
admet-210	26	64	.	.	PROPN
admet-210	26	65	louis	louis	PROPN
admet-210	26	66	,	,	PUNCT
admet-210	26	67	mo	mo	PROPN
admet-210	26	68	usa	usa	PROPN
admet-210	26	69	)	)	PUNCT
admet-210	26	70	.	.	PUNCT
admet-210	27	1	hplc	hplc	NOUN
admet-210	27	2	(	(	PUNCT
admet-210	27	3	high	high	ADJ
admet-210	27	4	performance	performance	NOUN
admet-210	27	5	liquid	liquid	NOUN
admet-210	27	6	chromatography	chromatography	NOUN
admet-210	27	7	)	)	PUNCT
admet-210	27	8	grade	grade	NOUN
admet-210	27	9	acetonitrile	acetonitrile	NOUN
admet-210	27	10	and	and	CCONJ
admet-210	27	11	methanol	methanol	NOUN
admet-210	27	12	were	be	AUX
admet-210	27	13	obtained	obtain	VERB
admet-210	27	14	from	from	ADP
admet-210	27	15	e	e	PROPN
admet-210	27	16	merck	merck	PROPN
admet-210	27	17	india	india	PROPN
admet-210	27	18	limited	limited	PROPN
admet-210	27	19	(	(	PUNCT
admet-210	27	20	mumbai	mumbai	PROPN
admet-210	27	21	,	,	PUNCT
admet-210	27	22	india	india	PROPN
admet-210	27	23	)	)	PUNCT
admet-210	27	24	,	,	PUNCT
admet-210	27	25	and	and	CCONJ
admet-210	27	26	all	all	DET
admet-210	27	27	the	the	DET
admet-210	27	28	other	other	ADJ
admet-210	27	29	chemicals	chemical	NOUN
admet-210	27	30	were	be	AUX
admet-210	27	31	used	use	VERB
admet-210	27	32	of	of	ADP
admet-210	27	33	highest	high	ADJ
admet-210	27	34	quality	quality	NOUN
admet-210	27	35	available	available	ADJ
admet-210	27	36	.	.	PUNCT
admet-210	28	1	hepatocytes	hepatocytes	PROPN
admet-210	28	2	isolation	isolation	NOUN
admet-210	28	3	,	,	PUNCT
admet-210	28	4	in	in	ADP
admet-210	28	5	vitro	vitro	X
admet-210	28	6	culture	culture	NOUN
admet-210	28	7	and	and	CCONJ
admet-210	28	8	characterization	characterization	NOUN
admet-210	28	9	human	human	ADJ
admet-210	28	10	fetal	fetal	ADJ
admet-210	28	11	livers	liver	NOUN
admet-210	28	12	were	be	AUX
admet-210	28	13	obtained	obtain	VERB
admet-210	28	14	from	from	ADP
admet-210	28	15	spontaneous	spontaneous	ADJ
admet-210	28	16	abortions	abortion	NOUN
admet-210	28	17	from	from	ADP
admet-210	28	18	10	10	NUM
admet-210	28	19	-	-	SYM
admet-210	28	20	14	14	NUM
admet-210	28	21	weeks	week	NOUN
admet-210	28	22	of	of	ADP
admet-210	28	23	gestation	gestation	NOUN
admet-210	28	24	.	.	PUNCT
admet-210	29	1	all	all	DET
admet-210	29	2	donors	donor	NOUN
admet-210	29	3	of	of	ADP
admet-210	29	4	the	the	DET
admet-210	29	5	fetus	fetus	NOUN
admet-210	29	6	were	be	AUX
admet-210	29	7	thoroughly	thoroughly	ADV
admet-210	29	8	screened	screen	VERB
admet-210	29	9	serologically	serologically	ADV
admet-210	29	10	for	for	ADP
admet-210	29	11	syphilis	syphilis	PROPN
admet-210	29	12	,	,	PUNCT
admet-210	29	13	toxoplasmosis	toxoplasmosis	NOUN
admet-210	29	14	,	,	PUNCT
admet-210	29	15	rubella	rubella	NOUN
admet-210	29	16	,	,	PUNCT
admet-210	29	17	hepatitis	hepatitis	PROPN
admet-210	29	18	b	b	PROPN
admet-210	29	19	and	and	CCONJ
admet-210	29	20	c	c	NOUN
admet-210	29	21	,	,	PUNCT
admet-210	29	22	human	human	ADJ
admet-210	29	23	immunodeficiency	immunodeficiency	NOUN
admet-210	29	24	virus	virus	NOUN
admet-210	29	25	1	1	NUM
admet-210	29	26	,	,	PUNCT
admet-210	29	27	cytomegalovirus	cytomegalovirus	NOUN
admet-210	29	28	,	,	PUNCT
admet-210	29	29	parvovirus	parvovirus	NOUN
admet-210	29	30	,	,	PUNCT
admet-210	29	31	and	and	CCONJ
admet-210	29	32	herpes	herpe	NOUN
admet-210	29	33	simplex	simplex	NOUN
admet-210	29	34	types	type	NOUN
admet-210	29	35	1	1	NUM
admet-210	29	36	and	and	CCONJ
admet-210	29	37	2	2	NUM
admet-210	29	38	.	.	PUNCT
admet-210	30	1	liver	liver	NOUN
admet-210	30	2	cells	cell	NOUN
admet-210	30	3	were	be	AUX
admet-210	30	4	isolated	isolate	VERB
admet-210	30	5	using	use	VERB
admet-210	30	6	two	two	NUM
admet-210	30	7	-	-	PUNCT
admet-210	30	8	step	step	NOUN
admet-210	30	9	collagenase	collagenase	NOUN
admet-210	30	10	perfusion	perfusion	NOUN
admet-210	30	11	method	method	NOUN
admet-210	30	12	as	as	SCONJ
admet-210	30	13	described	describe	VERB
admet-210	30	14	by	by	ADP
admet-210	30	15	habibullah	habibullah	PROPN
admet-210	30	16	et	et	PROPN
admet-210	30	17	al	al	PROPN
admet-210	31	1	[	[	X
admet-210	31	2	17	17	NUM
admet-210	31	3	]	]	PUNCT
admet-210	31	4	.	.	PUNCT
admet-210	32	1	briefly	briefly	NOUN
admet-210	32	2	,	,	PUNCT
admet-210	32	3	resected	resect	VERB
admet-210	32	4	liver	liver	NOUN
admet-210	32	5	from	from	ADP
admet-210	32	6	the	the	DET
admet-210	32	7	aborted	abort	VERB
admet-210	32	8	fetuses	fetus	NOUN
admet-210	32	9	were	be	AUX
admet-210	32	10	collected	collect	VERB
admet-210	32	11	under	under	ADP
admet-210	32	12	sterile	sterile	ADJ
admet-210	32	13	conditions	condition	NOUN
admet-210	32	14	within	within	ADP
admet-210	32	15	2h	2h	NUM
admet-210	32	16	of	of	ADP
admet-210	32	17	the	the	DET
admet-210	32	18	termination	termination	NOUN
admet-210	32	19	of	of	ADP
admet-210	32	20	pregnancy	pregnancy	NOUN
admet-210	32	21	and	and	CCONJ
admet-210	32	22	then	then	ADV
admet-210	32	23	cut	cut	VERB
admet-210	32	24	into	into	ADP
admet-210	32	25	thin	thin	ADJ
admet-210	32	26	slice	slice	NOUN
admet-210	32	27	(	(	PUNCT
admet-210	32	28	1	1	NUM
admet-210	32	29	-	-	SYM
admet-210	32	30	2	2	NUM
admet-210	32	31	mm	mm	NOUN
admet-210	32	32	thickness	thickness	NOUN
admet-210	32	33	)	)	PUNCT
admet-210	32	34	.	.	PUNCT
admet-210	33	1	thereafter	thereafter	ADV
admet-210	33	2	,	,	PUNCT
admet-210	33	3	each	each	DET
admet-210	33	4	fetal	fetal	ADJ
admet-210	33	5	liver	liver	NOUN
admet-210	33	6	was	be	AUX
admet-210	33	7	digested	digest	VERB
admet-210	33	8	with	with	ADP
admet-210	33	9	0.02	0.02	NUM
admet-210	33	10	%	%	NOUN
admet-210	33	11	collagenase	collagenase	NOUN
admet-210	33	12	type	type	NOUN
admet-210	33	13	iv	iv	ADP
admet-210	33	14	(	(	PUNCT
admet-210	33	15	sigmaaldrich	sigmaaldrich	PROPN
admet-210	33	16	,	,	PUNCT
admet-210	33	17	st	st	PROPN
admet-210	33	18	.	.	PROPN
admet-210	33	19	louis	louis	PROPN
admet-210	33	20	,	,	PUNCT
admet-210	33	21	usa	usa	PROPN
admet-210	33	22	)	)	PUNCT
admet-210	33	23	containing	contain	VERB
admet-210	33	24	penicillin	penicillin	NOUN
admet-210	33	25	g	g	PROPN
admet-210	33	26	(	(	PUNCT
admet-210	33	27	10	10	NUM
admet-210	33	28	u	u	NOUN
admet-210	33	29	/	/	SYM
admet-210	33	30	ml	ml	PROPN
admet-210	33	31	,	,	PUNCT
admet-210	33	32	streptomycin10	streptomycin10	VERB
admet-210	33	33	u	u	NOUN
admet-210	33	34	/	/	SYM
admet-210	33	35	ml	ml	PROPN
admet-210	33	36	,	,	PUNCT
admet-210	33	37	amphoteracin	amphoteracin	PROPN
admet-210	33	38	b	b	X
admet-210	33	39	(	(	PUNCT
admet-210	33	40	0.025	0.025	NUM
admet-210	33	41	μg	μg	PROPN
admet-210	33	42	/	/	SYM
admet-210	33	43	ml	ml	NOUN
admet-210	33	44	)	)	PUNCT
admet-210	33	45	at	at	ADP
admet-210	33	46	37	37	NUM
admet-210	33	47	°	°	NOUN
admet-210	33	48	c	c	NOUN
admet-210	33	49	for	for	ADP
admet-210	33	50	30	30	NUM
admet-210	33	51	min	min	NOUN
admet-210	33	52	.	.	PROPN
admet-210	33	53	single	single	ADJ
admet-210	33	54	cell	cell	NOUN
admet-210	33	55	suspension	suspension	NOUN
admet-210	33	56	of	of	ADP
admet-210	33	57	liver	liver	NOUN
admet-210	33	58	was	be	AUX
admet-210	33	59	collected	collect	VERB
admet-210	33	60	by	by	ADP
admet-210	33	61	centrifugation	centrifugation	NOUN
admet-210	33	62	at	at	ADP
admet-210	33	63	250	250	NUM
admet-210	33	64	g	g	NOUN
admet-210	33	65	and	and	CCONJ
admet-210	33	66	then	then	ADV
admet-210	33	67	washed	wash	VERB
admet-210	33	68	with	with	ADP
admet-210	33	69	sterile	sterile	ADJ
admet-210	33	70	phosphate	phosphate	NOUN
admet-210	33	71	buffered	buffer	VERB
admet-210	33	72	saline	saline	NOUN
admet-210	33	73	(	(	PUNCT
admet-210	33	74	pbs	pbs	PROPN
admet-210	33	75	ph	ph	PROPN
admet-210	33	76	7.4	7.4	NUM
admet-210	33	77	)	)	PUNCT
admet-210	33	78	.	.	PUNCT
admet-210	34	1	the	the	DET
admet-210	34	2	viability	viability	NOUN
admet-210	34	3	of	of	ADP
admet-210	34	4	the	the	DET
admet-210	34	5	cells	cell	NOUN
admet-210	34	6	was	be	AUX
admet-210	34	7	measured	measure	VERB
admet-210	34	8	using	use	VERB
admet-210	34	9	trypan	trypan	NOUN
admet-210	34	10	blue	blue	ADJ
admet-210	34	11	method	method	NOUN
admet-210	34	12	.	.	PUNCT
admet-210	35	1	cells	cell	NOUN
admet-210	35	2	showing	show	VERB
admet-210	35	3	more	more	ADJ
admet-210	35	4	than	than	ADP
admet-210	35	5	80	80	NUM
admet-210	35	6	%	%	NOUN
admet-210	35	7	viability	viability	NOUN
admet-210	35	8	were	be	AUX
admet-210	35	9	used	use	VERB
admet-210	35	10	for	for	ADP
admet-210	35	11	the	the	DET
admet-210	35	12	metabolism	metabolism	NOUN
admet-210	35	13	experiments	experiment	NOUN
admet-210	35	14	.	.	PUNCT
admet-210	36	1	metabolism	metabolism	NOUN
admet-210	36	2	studies	study	NOUN
admet-210	36	3	1	1	NUM
admet-210	36	4	ml	ml	NOUN
admet-210	36	5	of	of	ADP
admet-210	36	6	cell	cell	NOUN
admet-210	36	7	mixture	mixture	NOUN
admet-210	36	8	containing	contain	VERB
admet-210	36	9	1	1	NUM
admet-210	36	10	million	million	NUM
admet-210	36	11	cells	cell	NOUN
admet-210	36	12	per	per	ADP
admet-210	36	13	ml	ml	NOUN
admet-210	36	14	were	be	AUX
admet-210	36	15	transferred	transfer	VERB
admet-210	36	16	to	to	ADP
admet-210	36	17	a	a	DET
admet-210	36	18	12	12	NUM
admet-210	36	19	well	well	NOUN
admet-210	36	20	cell	cell	NOUN
admet-210	36	21	culture	culture	NOUN
admet-210	36	22	plate	plate	NOUN
admet-210	36	23	(	(	PUNCT
admet-210	36	24	costar	costar	NOUN
admet-210	36	25	)	)	PUNCT
admet-210	36	26	and	and	CCONJ
admet-210	36	27	10	10	NUM
admet-210	36	28	µl	µl	NOUN
admet-210	36	29	of	of	ADP
admet-210	36	30	test	test	NOUN
admet-210	36	31	compound	compound	NOUN
admet-210	36	32	(	(	PUNCT
admet-210	36	33	in	in	ADP
admet-210	36	34	dmso	dmso	ADJ
admet-210	36	35	water	water	NOUN
admet-210	36	36	)	)	PUNCT
admet-210	36	37	was	be	AUX
admet-210	36	38	added	add	VERB
admet-210	36	39	to	to	PART
admet-210	36	40	maintain	maintain	VERB
admet-210	36	41	a	a	DET
admet-210	36	42	final	final	ADJ
admet-210	36	43	volume	volume	NOUN
admet-210	36	44	of	of	ADP
admet-210	36	45	dmso	dmso	NOUN
admet-210	36	46	below	below	ADP
admet-210	36	47	0.2	0.2	NUM
admet-210	36	48	%	%	NOUN
admet-210	36	49	v	v	NOUN
admet-210	36	50	/	/	SYM
admet-210	36	51	v.	v.	ADP
admet-210	36	52	the	the	DET
admet-210	36	53	incubation	incubation	NOUN
admet-210	36	54	plate	plate	NOUN
admet-210	36	55	was	be	AUX
admet-210	36	56	then	then	ADV
admet-210	36	57	transferred	transfer	VERB
admet-210	36	58	to	to	ADP
admet-210	36	59	an	an	DET
admet-210	36	60	incubator	incubator	NOUN
admet-210	36	61	set	set	VERB
admet-210	36	62	at	at	ADP
admet-210	36	63	37	37	NUM
admet-210	36	64	°	°	ADP
admet-210	36	65	c	c	NOUN
admet-210	36	66	with	with	ADP
admet-210	36	67	a	a	DET
admet-210	36	68	relative	relative	ADJ
admet-210	36	69	humidity	humidity	NOUN
admet-210	36	70	of	of	ADP
admet-210	36	71	95	95	NUM
admet-210	36	72	%	%	NOUN
admet-210	36	73	and	and	CCONJ
admet-210	36	74	co2	co2	NOUN
admet-210	36	75	(	(	PUNCT
admet-210	36	76	carbon	carbon	NOUN
admet-210	36	77	dioxide	dioxide	NOUN
admet-210	36	78	)	)	PUNCT
admet-210	36	79	at	at	ADP
admet-210	36	80	5	5	NUM
admet-210	36	81	%	%	NOUN
admet-210	36	82	.	.	PUNCT
admet-210	37	1	the	the	DET
admet-210	37	2	samples	sample	NOUN
admet-210	37	3	were	be	AUX
admet-210	37	4	incubated	incubate	VERB
admet-210	37	5	for	for	ADP
admet-210	37	6	2	2	NUM
admet-210	37	7	h	h	NOUN
admet-210	37	8	and	and	CCONJ
admet-210	37	9	at	at	ADP
admet-210	37	10	the	the	DET
admet-210	37	11	end	end	NOUN
admet-210	37	12	of	of	ADP
admet-210	37	13	2	2	NUM
admet-210	37	14	h	h	NOUN
admet-210	37	15	viability	viability	NOUN
admet-210	37	16	of	of	ADP
admet-210	37	17	the	the	DET
admet-210	37	18	cells	cell	NOUN
admet-210	37	19	was	be	AUX
admet-210	37	20	checked	check	VERB
admet-210	37	21	using	use	VERB
admet-210	37	22	an	an	DET
admet-210	37	23	aliquot	aliquot	NOUN
admet-210	37	24	of	of	ADP
admet-210	37	25	20	20	NUM
admet-210	37	26	µl	µl	ADP
admet-210	37	27	mixture	mixture	NOUN
admet-210	37	28	.	.	PUNCT
admet-210	38	1	the	the	DET
admet-210	38	2	incubation	incubation	NOUN
admet-210	38	3	was	be	AUX
admet-210	38	4	terminated	terminate	VERB
admet-210	38	5	using	use	VERB
admet-210	38	6	4	4	NUM
admet-210	38	7	ml	ml	NOUN
admet-210	38	8	of	of	ADP
admet-210	38	9	acetonitrile	acetonitrile	NOUN
admet-210	38	10	containing	contain	VERB
admet-210	38	11	internal	internal	ADJ
admet-210	38	12	standard	standard	NOUN
admet-210	38	13	celecoxib	celecoxib	X
admet-210	38	14	(	(	PUNCT
admet-210	38	15	1	1	NUM
admet-210	38	16	mg	mg	NUM
admet-210	38	17	/	/	SYM
admet-210	38	18	ml	ml	NOUN
admet-210	38	19	)	)	PUNCT
admet-210	38	20	,	,	PUNCT
admet-210	38	21	vortex	vortex	NOUN
admet-210	38	22	mixed	mix	VERB
admet-210	38	23	for	for	ADP
admet-210	38	24	2	2	NUM
admet-210	38	25	mins	min	NOUN
admet-210	38	26	and	and	CCONJ
admet-210	38	27	centrifuged	centrifuge	VERB
admet-210	38	28	at	at	ADP
admet-210	38	29	3000	3000	NUM
admet-210	38	30	rpm	rpm	NOUN
admet-210	38	31	on	on	ADP
admet-210	38	32	a	a	DET
admet-210	38	33	table	table	NOUN
admet-210	38	34	top	top	NOUN
admet-210	38	35	centrifuge	centrifuge	NOUN
admet-210	38	36	(	(	PUNCT
admet-210	38	37	remi	remi	PROPN
admet-210	38	38	instruments	instruments	PROPN
admet-210	38	39	,	,	PUNCT
admet-210	38	40	india	india	PROPN
admet-210	38	41	)	)	PUNCT
admet-210	38	42	.	.	PUNCT
admet-210	39	1	the	the	DET
admet-210	39	2	supernatant	supernatant	NOUN
admet-210	39	3	was	be	AUX
admet-210	39	4	transferred	transfer	VERB
admet-210	39	5	to	to	ADP
admet-210	39	6	clean	clean	ADJ
admet-210	39	7	glass	glass	NOUN
admet-210	39	8	tube	tube	NOUN
admet-210	39	9	and	and	CCONJ
admet-210	39	10	the	the	DET
admet-210	39	11	contents	content	NOUN
admet-210	39	12	were	be	AUX
admet-210	39	13	dried	dry	VERB
admet-210	39	14	under	under	ADP
admet-210	39	15	gentle	gentle	ADJ
admet-210	39	16	stream	stream	NOUN
admet-210	39	17	of	of	ADP
admet-210	39	18	nitrogen	nitrogen	NOUN
admet-210	39	19	using	use	VERB
admet-210	39	20	a	a	DET
admet-210	39	21	multivap	multivap	NOUN
admet-210	39	22	evaporator	evaporator	NOUN
admet-210	39	23	set	set	VERB
admet-210	39	24	at	at	ADP
admet-210	39	25	40	40	NUM
admet-210	39	26	°	°	NOUN
admet-210	39	27	c	c	NOUN
admet-210	39	28	(	(	PUNCT
admet-210	39	29	n	n	CCONJ
admet-210	39	30	-	-	PUNCT
admet-210	39	31	evap	evap	NOUN
admet-210	39	32	,	,	PUNCT
admet-210	39	33	orgiinomation	orgiinomation	NOUN
admet-210	39	34	,	,	PUNCT
admet-210	39	35	berlin	berlin	PROPN
admet-210	39	36	,	,	PUNCT
admet-210	39	37	ma	ma	PROPN
admet-210	39	38	,	,	PUNCT
admet-210	39	39	usa	usa	PROPN
admet-210	39	40	)	)	PUNCT
admet-210	39	41	.	.	PUNCT
admet-210	40	1	the	the	DET
admet-210	40	2	residue	residue	NOUN
admet-210	40	3	was	be	AUX
admet-210	40	4	reconstituted	reconstitute	VERB
admet-210	40	5	in	in	ADP
admet-210	40	6	200	200	NUM
admet-210	40	7	µl	µl	NOUN
admet-210	40	8	of	of	ADP
admet-210	40	9	mobile	mobile	ADJ
admet-210	40	10	phase	phase	NOUN
admet-210	40	11	(	(	PUNCT
admet-210	40	12	a	a	DET
admet-210	40	13	:	:	SYM
admet-210	40	14	b	b	NOUN
admet-210	40	15	,	,	PUNCT
admet-210	40	16	1:1	1:1	NUM
admet-210	40	17	)	)	PUNCT
admet-210	40	18	and	and	CCONJ
admet-210	40	19	100	100	NUM
admet-210	40	20	µl	µl	ADP
admet-210	40	21	of	of	ADP
admet-210	40	22	this	this	DET
admet-210	40	23	solution	solution	NOUN
admet-210	40	24	was	be	AUX
admet-210	40	25	injected	inject	VERB
admet-210	40	26	into	into	ADP
admet-210	40	27	the	the	DET
admet-210	40	28	hplc	hplc	NOUN
admet-210	40	29	.	.	PUNCT
admet-210	41	1	for	for	ADP
admet-210	41	2	0	0	NUM
admet-210	41	3	h	h	NOUN
admet-210	41	4	samples	sample	NOUN
admet-210	41	5	,	,	PUNCT
admet-210	41	6	acetonitrile	acetonitrile	NOUN
admet-210	41	7	was	be	AUX
admet-210	41	8	added	add	VERB
admet-210	41	9	prior	prior	ADV
admet-210	41	10	to	to	ADP
admet-210	41	11	addition	addition	NOUN
admet-210	41	12	of	of	ADP
admet-210	41	13	test	test	NOUN
admet-210	41	14	compound	compound	NOUN
admet-210	41	15	to	to	PART
admet-210	41	16	prevent	prevent	VERB
admet-210	41	17	the	the	DET
admet-210	41	18	reaction	reaction	NOUN
admet-210	41	19	followed	follow	VERB
admet-210	41	20	by	by	ADP
admet-210	41	21	the	the	DET
admet-210	41	22	above	above	ADJ
admet-210	41	23	described	describe	VERB
admet-210	41	24	sample	sample	NOUN
admet-210	41	25	preparation	preparation	NOUN
admet-210	41	26	method	method	NOUN
admet-210	41	27	.	.	PUNCT
admet-210	42	1	each	each	PRON
admet-210	42	2	of	of	ADP
admet-210	42	3	the	the	DET
admet-210	42	4	test	test	NOUN
admet-210	42	5	compounds	compound	NOUN
admet-210	42	6	was	be	AUX
admet-210	42	7	incubated	incubate	VERB
admet-210	42	8	in	in	ADP
admet-210	42	9	triplicates	triplicate	NOUN
admet-210	42	10	;	;	PUNCT
admet-210	42	11	the	the	DET
admet-210	42	12	area	area	NOUN
admet-210	42	13	of	of	ADP
admet-210	42	14	the	the	DET
admet-210	42	15	drug	drug	NOUN
admet-210	42	16	was	be	AUX
admet-210	42	17	divided	divide	VERB
admet-210	42	18	by	by	ADP
admet-210	42	19	the	the	DET
admet-210	42	20	area	area	NOUN
admet-210	42	21	of	of	ADP
admet-210	42	22	shaik	shaik	PROPN
admet-210	42	23	et	et	PROPN
admet-210	42	24	al	al	PROPN
admet-210	42	25	.	.	PROPN
admet-210	42	26	admet	admet	PROPN
admet-210	42	27	&	&	CCONJ
admet-210	42	28	dmpk	dmpk	PROPN
admet-210	42	29	4(2	4(2	NUM
admet-210	42	30	)	)	PUNCT
admet-210	42	31	(	(	PUNCT
admet-210	42	32	2016	2016	NUM
admet-210	42	33	)	)	PUNCT
admet-210	42	34	84	84	NUM
admet-210	42	35	-	-	SYM
admet-210	42	36	90	90	NUM
admet-210	42	37	86	86	NUM
admet-210	42	38	the	the	DET
admet-210	42	39	internal	internal	ADJ
admet-210	42	40	standard	standard	NOUN
admet-210	42	41	to	to	PART
admet-210	42	42	get	get	VERB
admet-210	42	43	the	the	DET
admet-210	42	44	area	area	NOUN
admet-210	42	45	ratio	ratio	NOUN
admet-210	42	46	.	.	PUNCT
admet-210	43	1	the	the	DET
admet-210	43	2	area	area	NOUN
admet-210	43	3	ratio	ratio	NOUN
admet-210	43	4	obtained	obtain	VERB
admet-210	43	5	from	from	ADP
admet-210	43	6	0	0	NUM
admet-210	43	7	h	h	NOUN
admet-210	43	8	was	be	AUX
admet-210	43	9	considered	consider	VERB
admet-210	43	10	as	as	ADP
admet-210	43	11	100	100	NUM
admet-210	43	12	%	%	NOUN
admet-210	43	13	and	and	CCONJ
admet-210	43	14	the	the	DET
admet-210	43	15	area	area	NOUN
admet-210	43	16	ratio	ratio	NOUN
admet-210	43	17	of	of	ADP
admet-210	43	18	2	2	NUM
admet-210	43	19	h	h	NOUN
admet-210	43	20	sample	sample	NOUN
admet-210	43	21	was	be	AUX
admet-210	43	22	calculated	calculate	VERB
admet-210	43	23	to	to	PART
admet-210	43	24	get	get	VERB
admet-210	43	25	the	the	DET
admet-210	43	26	metabolic	metabolic	NOUN
admet-210	43	27	stability	stability	NOUN
admet-210	43	28	of	of	ADP
admet-210	43	29	the	the	DET
admet-210	43	30	test	test	NOUN
admet-210	43	31	compound	compound	NOUN
admet-210	43	32	.	.	PUNCT
admet-210	44	1	each	each	PRON
admet-210	44	2	of	of	ADP
admet-210	44	3	the	the	DET
admet-210	44	4	experiment	experiment	NOUN
admet-210	44	5	was	be	AUX
admet-210	44	6	conducted	conduct	VERB
admet-210	44	7	at	at	ADP
admet-210	44	8	least	least	ADV
admet-210	44	9	three	three	NUM
admet-210	44	10	times	time	NOUN
admet-210	44	11	on	on	ADP
admet-210	44	12	different	different	ADJ
admet-210	44	13	days	day	NOUN
admet-210	44	14	with	with	ADP
admet-210	44	15	new	new	ADJ
admet-210	44	16	fetal	fetal	ADJ
admet-210	44	17	hepatocytes	hepatocyte	NOUN
admet-210	44	18	.	.	PUNCT
admet-210	45	1	instrumentation	instrumentation	NOUN
admet-210	45	2	and	and	CCONJ
admet-210	45	3	chromatographic	chromatographic	ADJ
admet-210	45	4	conditions	condition	NOUN
admet-210	45	5	hplc	hplc	NOUN
admet-210	45	6	analysis	analysis	NOUN
admet-210	45	7	was	be	AUX
admet-210	45	8	performed	perform	VERB
admet-210	45	9	using	use	VERB
admet-210	45	10	the	the	DET
admet-210	45	11	previously	previously	ADV
admet-210	45	12	published	publish	VERB
admet-210	45	13	method	method	NOUN
admet-210	45	14	[	[	X
admet-210	45	15	18	18	NUM
admet-210	45	16	]	]	PUNCT
admet-210	45	17	.	.	PUNCT
admet-210	46	1	in	in	ADP
admet-210	46	2	brief	brief	ADJ
admet-210	46	3	,	,	PUNCT
admet-210	46	4	hplc	hplc	NOUN
admet-210	46	5	system	system	NOUN
admet-210	46	6	consisted	consist	VERB
admet-210	46	7	of	of	ADP
admet-210	46	8	a	a	DET
admet-210	46	9	waters	water	NOUN
admet-210	46	10	2695	2695	NUM
admet-210	46	11	alliance	alliance	NOUN
admet-210	46	12	separation	separation	NOUN
admet-210	46	13	module	module	NOUN
admet-210	46	14	attached	attach	VERB
admet-210	46	15	with	with	ADP
admet-210	46	16	a	a	DET
admet-210	46	17	waters	water	NOUN
admet-210	46	18	2996	2996	NUM
admet-210	46	19	photodiode	photodiode	NOUN
admet-210	46	20	array	array	NOUN
admet-210	46	21	(	(	PUNCT
admet-210	46	22	pda	pda	NOUN
admet-210	46	23	)	)	PUNCT
admet-210	46	24	detector	detector	NOUN
admet-210	46	25	,	,	PUNCT
admet-210	46	26	the	the	DET
admet-210	46	27	instrument	instrument	NOUN
admet-210	46	28	was	be	AUX
admet-210	46	29	setup	setup	NOUN
admet-210	46	30	to	to	PART
admet-210	46	31	detect	detect	VERB
admet-210	46	32	a	a	DET
admet-210	46	33	range	range	NOUN
admet-210	46	34	of	of	ADP
admet-210	46	35	190	190	NUM
admet-210	46	36	-	-	SYM
admet-210	46	37	400	400	NUM
admet-210	46	38	nm	nm	NOUN
admet-210	46	39	.	.	PUNCT
admet-210	47	1	a	a	DET
admet-210	47	2	c18	c18	NOUN
admet-210	47	3	inertsil	inertsil	PROPN
admet-210	47	4	ods	ods	PROPN
admet-210	47	5	3v	3v	NUM
admet-210	47	6	column	column	NOUN
admet-210	47	7	(	(	PUNCT
admet-210	47	8	4.6	4.6	NUM
admet-210	47	9	x	x	SYM
admet-210	47	10	250	250	NUM
admet-210	47	11	mm	mm	NOUN
admet-210	47	12	,	,	PUNCT
admet-210	47	13	5	5	NUM
admet-210	47	14	µm	µm	NOUN
admet-210	47	15	,	,	PUNCT
admet-210	47	16	gl	gl	PROPN
admet-210	47	17	sciences	sciences	PROPN
admet-210	47	18	,	,	PUNCT
admet-210	47	19	inc	inc	PROPN
admet-210	47	20	.	.	PROPN
admet-210	47	21	,	,	PUNCT
admet-210	47	22	tokyo	tokyo	PROPN
admet-210	47	23	,	,	PUNCT
admet-210	47	24	japan	japan	PROPN
admet-210	47	25	)	)	PUNCT
admet-210	47	26	was	be	AUX
admet-210	47	27	used	use	VERB
admet-210	47	28	for	for	ADP
admet-210	47	29	the	the	DET
admet-210	47	30	analysis	analysis	NOUN
admet-210	47	31	.	.	PUNCT
admet-210	48	1	a	a	DET
admet-210	48	2	ternary	ternary	ADJ
admet-210	48	3	mobile	mobile	ADJ
admet-210	48	4	phase	phase	NOUN
admet-210	48	5	gradient	gradient	NOUN
admet-210	48	6	system	system	NOUN
admet-210	48	7	was	be	AUX
admet-210	48	8	used	use	VERB
admet-210	48	9	consisting	consist	VERB
admet-210	48	10	of	of	ADP
admet-210	48	11	a	a	DET
admet-210	48	12	(	(	PUNCT
admet-210	48	13	0.01	0.01	NUM
admet-210	48	14	m	m	NOUN
admet-210	48	15	ammonium	ammonium	NOUN
admet-210	48	16	acetate	acetate	NOUN
admet-210	48	17	,	,	PUNCT
admet-210	48	18	ph	ph	VERB
admet-210	48	19	5.0	5.0	NUM
admet-210	48	20	:	:	PUNCT
admet-210	48	21	acetonitrile	acetonitrile	NOUN
admet-210	48	22	;	;	PUNCT
admet-210	48	23	90:10	90:10	NUM
admet-210	48	24	)	)	PUNCT
admet-210	48	25	,	,	PUNCT
admet-210	48	26	b	b	X
admet-210	48	27	(	(	PUNCT
admet-210	48	28	0.01	0.01	NUM
admet-210	48	29	m	m	PROPN
admet-210	48	30	ammonium	ammonium	NOUN
admet-210	48	31	acetate	acetate	NOUN
admet-210	48	32	buffer	buffer	NOUN
admet-210	48	33	,	,	PUNCT
admet-210	48	34	ph	ph	NOUN
admet-210	48	35	5.0	5.0	NUM
admet-210	48	36	:	:	PUNCT
admet-210	48	37	acetonitrile	acetonitrile	NOUN
admet-210	48	38	;	;	PUNCT
admet-210	48	39	5:95	5:95	NUM
admet-210	48	40	)	)	PUNCT
admet-210	48	41	and	and	CCONJ
admet-210	48	42	c0.01	c0.01	PROPN
admet-210	48	43	mm	mm	PROPN
admet-210	48	44	ammonium	ammonium	NOUN
admet-210	48	45	acetate	acetate	NOUN
admet-210	48	46	buffer	buffer	NOUN
admet-210	48	47	,	,	PUNCT
admet-210	48	48	ph	ph	NOUN
admet-210	48	49	5.0	5.0	NUM
admet-210	48	50	:	:	PUNCT
admet-210	48	51	methanol	methanol	NOUN
admet-210	48	52	;	;	PUNCT
admet-210	48	53	5:95	5:95	NUM
admet-210	48	54	)	)	PUNCT
admet-210	48	55	,	,	PUNCT
admet-210	48	56	the	the	DET
admet-210	48	57	total	total	ADJ
admet-210	48	58	run	run	NOUN
admet-210	48	59	time	time	NOUN
admet-210	48	60	was	be	AUX
admet-210	48	61	40	40	NUM
admet-210	48	62	minutes	minute	NOUN
admet-210	48	63	with	with	ADP
admet-210	48	64	gradient	gradient	ADJ
admet-210	48	65	flow	flow	NOUN
admet-210	48	66	shown	show	VERB
admet-210	48	67	in	in	ADP
admet-210	48	68	table	table	NOUN
admet-210	48	69	1	1	NUM
admet-210	48	70	,	,	PUNCT
admet-210	48	71	analysis	analysis	NOUN
admet-210	48	72	was	be	AUX
admet-210	48	73	performed	perform	VERB
admet-210	48	74	by	by	ADP
admet-210	48	75	integrating	integrate	VERB
admet-210	48	76	the	the	DET
admet-210	48	77	peak	peak	NOUN
admet-210	48	78	area	area	NOUN
admet-210	48	79	of	of	ADP
admet-210	48	80	the	the	DET
admet-210	48	81	individual	individual	ADJ
admet-210	48	82	peaks	peak	NOUN
admet-210	48	83	at	at	ADP
admet-210	48	84	uv	uv	NOUN
admet-210	48	85	(	(	PUNCT
admet-210	48	86	ultraviolet	ultraviolet	NOUN
admet-210	48	87	)	)	PUNCT
admet-210	48	88	maximum	maximum	NOUN
admet-210	48	89	as	as	SCONJ
admet-210	48	90	described	describe	VERB
admet-210	48	91	by	by	ADP
admet-210	48	92	rao	rao	PROPN
admet-210	48	93	et	et	PROPN
admet-210	48	94	al	al	PROPN
admet-210	49	1	[	[	X
admet-210	49	2	18	18	NUM
admet-210	49	3	]	]	PUNCT
admet-210	49	4	and	and	CCONJ
admet-210	49	5	shown	show	VERB
admet-210	49	6	in	in	ADP
admet-210	49	7	table	table	NOUN
admet-210	49	8	2	2	NUM
admet-210	49	9	.	.	PUNCT
admet-210	49	10	similarly	similarly	ADV
admet-210	49	11	,	,	PUNCT
admet-210	49	12	the	the	DET
admet-210	49	13	peak	peak	NOUN
admet-210	49	14	area	area	NOUN
admet-210	49	15	counts	count	NOUN
admet-210	49	16	of	of	ADP
admet-210	49	17	internal	internal	ADJ
admet-210	49	18	standard	standard	NOUN
admet-210	49	19	was	be	AUX
admet-210	49	20	integrated	integrate	VERB
admet-210	49	21	.	.	PUNCT
admet-210	50	1	the	the	DET
admet-210	50	2	area	area	NOUN
admet-210	50	3	counts	count	NOUN
admet-210	50	4	of	of	ADP
admet-210	50	5	test	test	NOUN
admet-210	50	6	compound	compound	NOUN
admet-210	50	7	was	be	AUX
admet-210	50	8	divided	divide	VERB
admet-210	50	9	by	by	ADP
admet-210	50	10	the	the	DET
admet-210	50	11	area	area	NOUN
admet-210	50	12	counts	count	NOUN
admet-210	50	13	obtained	obtain	VERB
admet-210	50	14	from	from	ADP
admet-210	50	15	the	the	DET
admet-210	50	16	internal	internal	ADJ
admet-210	50	17	standard	standard	NOUN
admet-210	50	18	(	(	PUNCT
admet-210	50	19	is	be	AUX
admet-210	50	20	)	)	PUNCT
admet-210	50	21	within	within	ADP
admet-210	50	22	the	the	DET
admet-210	50	23	same	same	ADJ
admet-210	50	24	analytical	analytical	ADJ
admet-210	50	25	run	run	NOUN
admet-210	50	26	to	to	PART
admet-210	50	27	get	get	VERB
admet-210	50	28	the	the	DET
admet-210	50	29	area	area	NOUN
admet-210	50	30	ratios	ratio	NOUN
admet-210	50	31	which	which	PRON
admet-210	50	32	were	be	AUX
admet-210	50	33	used	use	VERB
admet-210	50	34	to	to	PART
admet-210	50	35	calculate	calculate	VERB
admet-210	50	36	the	the	DET
admet-210	50	37	%	%	NOUN
admet-210	50	38	depletion	depletion	NOUN
admet-210	50	39	of	of	ADP
admet-210	50	40	the	the	DET
admet-210	50	41	parent	parent	NOUN
admet-210	50	42	compound	compound	VERB
admet-210	50	43	over	over	ADP
admet-210	50	44	a	a	DET
admet-210	50	45	period	period	NOUN
admet-210	50	46	of	of	ADP
admet-210	50	47	2	2	NUM
admet-210	50	48	h.	h.	NOUN
admet-210	50	49	data	datum	NOUN
admet-210	50	50	analysis	analysis	NOUN
admet-210	50	51	the	the	DET
admet-210	50	52	data	datum	NOUN
admet-210	50	53	was	be	AUX
admet-210	50	54	plotted	plot	VERB
admet-210	50	55	using	use	VERB
admet-210	50	56	prism	prism	NOUN
admet-210	50	57	software	software	NOUN
admet-210	50	58	(	(	PUNCT
admet-210	50	59	graphpad	graphpad	PROPN
admet-210	50	60	software	software	PROPN
admet-210	50	61	inc	inc	PROPN
admet-210	50	62	.	.	PROPN
admet-210	50	63	,	,	PUNCT
admet-210	50	64	san	san	PROPN
admet-210	50	65	diego	diego	PROPN
admet-210	50	66	,	,	PUNCT
admet-210	50	67	ca	ca	NOUN
admet-210	50	68	)	)	PUNCT
admet-210	50	69	,	,	PUNCT
admet-210	50	70	all	all	DET
admet-210	50	71	data	datum	NOUN
admet-210	50	72	are	be	AUX
admet-210	50	73	presented	present	VERB
admet-210	50	74	as	as	ADP
admet-210	50	75	the	the	DET
admet-210	50	76	mean	mean	NOUN
admet-210	50	77	of	of	ADP
admet-210	50	78	each	each	DET
admet-210	50	79	group	group	NOUN
admet-210	50	80	±	±	PROPN
admet-210	50	81	s.e.m	s.e.m	NOUN
admet-210	50	82	.	.	PUNCT
admet-210	51	1	(	(	PUNCT
admet-210	51	2	standard	standard	ADJ
admet-210	51	3	error	error	NOUN
admet-210	51	4	of	of	ADP
admet-210	51	5	mean	mean	NOUN
admet-210	51	6	)	)	PUNCT
admet-210	51	7	as	as	SCONJ
admet-210	51	8	indicated	indicate	VERB
admet-210	51	9	in	in	ADP
admet-210	51	10	the	the	DET
admet-210	51	11	figure	figure	NOUN
admet-210	51	12	legend	legend	NOUN
admet-210	51	13	.	.	PUNCT
admet-210	52	1	metabolic	metabolic	NOUN
admet-210	52	2	stability	stability	NOUN
admet-210	52	3	was	be	AUX
admet-210	52	4	calculated	calculate	VERB
admet-210	52	5	using	use	VERB
admet-210	52	6	the	the	DET
admet-210	52	7	substrate	substrate	NOUN
admet-210	52	8	depletion	depletion	NOUN
admet-210	52	9	approach	approach	NOUN
admet-210	52	10	[	[	X
admet-210	52	11	19	19	NUM
admet-210	52	12	]	]	PUNCT
admet-210	52	13	,	,	PUNCT
admet-210	52	14	using	use	VERB
admet-210	52	15	the	the	DET
admet-210	52	16	equation	equation	NOUN
admet-210	52	17	below	below	ADP
admet-210	52	18	[	[	X
admet-210	52	19	20	20	NUM
admet-210	52	20	]	]	PUNCT
admet-210	52	21	.	.	PUNCT
admet-210	53	1	ratio	ratio	NOUN
admet-210	53	2	of	of	ADP
admet-210	53	3	substrate	substrate	NOUN
admet-210	53	4	in	in	ADP
admet-210	53	5	test	test	NOUN
admet-210	53	6	sample	sample	NOUN
admet-210	53	7	%	%	NOUN
admet-210	53	8	substrate	substrate	NOUN
admet-210	53	9	remained	remain	VERB
admet-210	53	10	in	in	ADP
admet-210	53	11	test	test	NOUN
admet-210	53	12	sample	sample	NOUN
admet-210	53	13	=	=	PUNCT
admet-210	54	1	*	*	PUNCT
admet-210	54	2	100	100	NUM
admet-210	54	3	ratio	ratio	NOUN
admet-210	54	4	of	of	ADP
admet-210	54	5	substrate	substrate	NOUN
admet-210	54	6	in	in	ADP
admet-210	54	7	control	control	NOUN
admet-210	54	8	sample	sample	NOUN
admet-210	54	9	results	result	NOUN
admet-210	54	10	and	and	CCONJ
admet-210	54	11	discussion	discussion	NOUN
admet-210	54	12	isolation	isolation	NOUN
admet-210	54	13	of	of	ADP
admet-210	54	14	hepatocytes	hepatocyte	NOUN
admet-210	54	15	from	from	ADP
admet-210	54	16	the	the	DET
admet-210	54	17	fetal	fetal	ADJ
admet-210	54	18	liver	liver	NOUN
admet-210	54	19	resulted	result	VERB
admet-210	54	20	in	in	ADP
admet-210	54	21	80	80	NUM
admet-210	54	22	%	%	NOUN
admet-210	54	23	viable	viable	ADJ
admet-210	54	24	cell	cell	NOUN
admet-210	54	25	,	,	PUNCT
admet-210	54	26	isolation	isolation	NOUN
admet-210	54	27	resulting	result	VERB
admet-210	54	28	in	in	ADP
admet-210	54	29	less	less	ADJ
admet-210	54	30	than	than	ADP
admet-210	54	31	80	80	NUM
admet-210	54	32	%	%	NOUN
admet-210	54	33	viability	viability	NOUN
admet-210	54	34	,	,	PUNCT
admet-210	54	35	or	or	CCONJ
admet-210	54	36	cells	cell	NOUN
admet-210	54	37	showing	show	VERB
admet-210	54	38	visible	visible	ADJ
admet-210	54	39	signs	sign	NOUN
admet-210	54	40	of	of	ADP
admet-210	54	41	deterioration	deterioration	NOUN
admet-210	54	42	were	be	AUX
admet-210	54	43	not	not	PART
admet-210	54	44	considered	consider	VERB
admet-210	54	45	for	for	ADP
admet-210	54	46	metabolism	metabolism	NOUN
admet-210	54	47	experiments	experiment	NOUN
admet-210	54	48	.	.	PUNCT
admet-210	55	1	figure	figure	NOUN
admet-210	55	2	1	1	NUM
admet-210	55	3	shows	show	VERB
admet-210	55	4	microscopic	microscopic	ADJ
admet-210	55	5	image	image	NOUN
admet-210	55	6	of	of	ADP
admet-210	55	7	the	the	DET
admet-210	55	8	14	14	NUM
admet-210	55	9	week	week	NOUN
admet-210	55	10	old	old	ADJ
admet-210	55	11	healthy	healthy	ADJ
admet-210	55	12	hepatocytes	hepatocyte	NOUN
admet-210	55	13	.	.	PUNCT
admet-210	56	1	six	six	NUM
admet-210	56	2	of	of	ADP
admet-210	56	3	the	the	DET
admet-210	56	4	commonly	commonly	ADV
admet-210	56	5	used	use	VERB
admet-210	56	6	probe	probe	NOUN
admet-210	56	7	substrates	substrate	NOUN
admet-210	56	8	,	,	PUNCT
admet-210	56	9	phenacetin	phenacetin	VERB
admet-210	56	10	at	at	ADP
admet-210	56	11	a	a	DET
admet-210	56	12	concentration	concentration	NOUN
admet-210	56	13	of	of	ADP
admet-210	56	14	100	100	NUM
admet-210	56	15	µm	µm	NOUN
admet-210	56	16	as	as	ADP
admet-210	56	17	a	a	DET
admet-210	56	18	substrate	substrate	NOUN
admet-210	56	19	of	of	ADP
admet-210	56	20	cyp1a2	cyp1a2	NOUN
admet-210	56	21	[	[	X
admet-210	56	22	21	21	NUM
admet-210	56	23	]	]	PUNCT
admet-210	56	24	,	,	PUNCT
admet-210	56	25	diclofenac	diclofenac	NOUN
admet-210	56	26	at	at	ADP
admet-210	56	27	a	a	DET
admet-210	56	28	concentration	concentration	NOUN
admet-210	56	29	of	of	ADP
admet-210	56	30	25	25	NUM
admet-210	56	31	µm	µm	NOUN
admet-210	56	32	as	as	ADP
admet-210	56	33	a	a	DET
admet-210	56	34	substrate	substrate	NOUN
admet-210	56	35	of	of	ADP
admet-210	56	36	cyp2c9	cyp2c9	NOUN
admet-210	57	1	[	[	X
admet-210	57	2	22	22	NUM
admet-210	57	3	]	]	PUNCT
admet-210	57	4	,	,	PUNCT
admet-210	57	5	s	s	NOUN
admet-210	57	6	-	-	NOUN
admet-210	57	7	mephenytoin	mephenytoin	NOUN
admet-210	57	8	at	at	ADP
admet-210	57	9	a	a	DET
admet-210	57	10	concentration	concentration	NOUN
admet-210	57	11	of	of	ADP
admet-210	57	12	5	5	NUM
admet-210	57	13	µm	µm	NOUN
admet-210	57	14	as	as	ADP
admet-210	57	15	a	a	DET
admet-210	57	16	substrate	substrate	NOUN
admet-210	57	17	of	of	ADP
admet-210	57	18	cyp2c19	cyp2c19	NOUN
admet-210	58	1	[	[	X
admet-210	58	2	23	23	NUM
admet-210	58	3	]	]	PUNCT
admet-210	58	4	,	,	PUNCT
admet-210	58	5	dextromethorphan	dextromethorphan	NOUN
admet-210	58	6	at	at	ADP
admet-210	58	7	a	a	DET
admet-210	58	8	concentration	concentration	NOUN
admet-210	58	9	of	of	ADP
admet-210	58	10	50	50	NUM
admet-210	58	11	µm	µm	NOUN
admet-210	58	12	as	as	ADP
admet-210	58	13	a	a	DET
admet-210	58	14	substrate	substrate	NOUN
admet-210	58	15	of	of	ADP
admet-210	58	16	cyp2d6	cyp2d6	NOUN
admet-210	58	17	[	[	X
admet-210	58	18	24	24	NUM
admet-210	58	19	]	]	PUNCT
admet-210	58	20	,	,	PUNCT
admet-210	58	21	nifedipine	nifedipine	NOUN
admet-210	58	22	at	at	ADP
admet-210	58	23	a	a	DET
admet-210	58	24	concentration	concentration	NOUN
admet-210	58	25	of	of	ADP
admet-210	58	26	5	5	NUM
admet-210	58	27	µm	µm	NOUN
admet-210	58	28	as	as	ADP
admet-210	58	29	a	a	DET
admet-210	58	30	substrate	substrate	NOUN
admet-210	58	31	of	of	ADP
admet-210	58	32	cyp3a4	cyp3a4	NOUN
admet-210	58	33	and	and	CCONJ
admet-210	58	34	testosterone	testosterone	NOUN
admet-210	58	35	at	at	ADP
admet-210	58	36	a	a	DET
admet-210	58	37	concentration	concentration	NOUN
admet-210	58	38	of	of	ADP
admet-210	58	39	120	120	NUM
admet-210	58	40	µm	µm	NOUN
admet-210	58	41	as	as	ADP
admet-210	58	42	a	a	DET
admet-210	58	43	substrate	substrate	NOUN
admet-210	58	44	of	of	ADP
admet-210	58	45	cyp3a4	cyp3a4	NOUN
admet-210	58	46	[	[	X
admet-210	58	47	25	25	NUM
admet-210	58	48	]	]	PUNCT
admet-210	58	49	,	,	PUNCT
admet-210	58	50	were	be	AUX
admet-210	58	51	used	use	VERB
admet-210	58	52	to	to	PART
admet-210	58	53	evaluate	evaluate	VERB
admet-210	58	54	the	the	DET
admet-210	58	55	contribution	contribution	NOUN
admet-210	58	56	towards	towards	ADP
admet-210	58	57	fetal	fetal	ADJ
admet-210	58	58	metabolism	metabolism	NOUN
admet-210	58	59	.	.	PUNCT
admet-210	59	1	these	these	DET
admet-210	59	2	concentrations	concentration	NOUN
admet-210	59	3	were	be	AUX
admet-210	59	4	chosen	choose	VERB
admet-210	59	5	based	base	VERB
admet-210	59	6	on	on	ADP
admet-210	59	7	in	in	ADP
admet-210	59	8	-	-	PUNCT
admet-210	59	9	house	house	NOUN
admet-210	59	10	km	km	NOUN
admet-210	59	11	values	value	NOUN
admet-210	59	12	generated	generate	VERB
admet-210	59	13	using	use	VERB
admet-210	59	14	liver	liver	NOUN
admet-210	59	15	microsomes	microsome	NOUN
admet-210	59	16	and	and	CCONJ
admet-210	59	17	hepatocytes	hepatocyte	NOUN
admet-210	59	18	and	and	CCONJ
admet-210	59	19	with	with	ADP
admet-210	59	20	reference	reference	NOUN
admet-210	59	21	to	to	ADP
admet-210	59	22	the	the	DET
admet-210	59	23	concentrations	concentration	NOUN
admet-210	59	24	suggested	suggest	VERB
admet-210	59	25	by	by	ADP
admet-210	59	26	the	the	DET
admet-210	59	27	fda	fda	PROPN
admet-210	59	28	(	(	PUNCT
admet-210	59	29	food	food	NOUN
admet-210	59	30	and	and	CCONJ
admet-210	59	31	drug	drug	NOUN
admet-210	59	32	administration	administration	NOUN
admet-210	59	33	)	)	PUNCT
admet-210	59	34	guidance	guidance	NOUN
admet-210	59	35	for	for	ADP
admet-210	59	36	drug	drug	NOUN
admet-210	59	37	interaction	interaction	NOUN
admet-210	59	38	studies	study	NOUN
admet-210	59	39	2006	2006	NUM
admet-210	59	40	[	[	X
admet-210	59	41	16	16	NUM
admet-210	59	42	,	,	PUNCT
admet-210	59	43	26	26	NUM
admet-210	59	44	]	]	PUNCT
admet-210	59	45	.	.	PUNCT
admet-210	60	1	each	each	PRON
admet-210	60	2	of	of	ADP
admet-210	60	3	the	the	DET
admet-210	60	4	marker	marker	NOUN
admet-210	60	5	reaction	reaction	NOUN
admet-210	60	6	was	be	AUX
admet-210	60	7	monitored	monitor	VERB
admet-210	60	8	by	by	ADP
admet-210	60	9	comparing	compare	VERB
admet-210	60	10	the	the	DET
admet-210	60	11	uv	uv	NOUN
admet-210	60	12	peak	peak	NOUN
admet-210	60	13	of	of	ADP
admet-210	60	14	metabolite	metabolite	NOUN
admet-210	60	15	with	with	ADP
admet-210	60	16	the	the	DET
admet-210	60	17	analytical	analytical	ADJ
admet-210	60	18	standard	standard	NOUN
admet-210	60	19	of	of	ADP
admet-210	60	20	each	each	DET
admet-210	60	21	metabolite	metabolite	NOUN
admet-210	60	22	.	.	PUNCT
admet-210	61	1	the	the	DET
admet-210	61	2	peak	peak	NOUN
admet-210	61	3	area	area	NOUN
admet-210	61	4	of	of	ADP
admet-210	61	5	all	all	DET
admet-210	61	6	the	the	DET
admet-210	61	7	test	test	NOUN
admet-210	61	8	compound	compound	NOUN
admet-210	61	9	was	be	AUX
admet-210	61	10	obtained	obtain	VERB
admet-210	61	11	at	at	ADP
admet-210	61	12	lambda	lambda	ADJ
admet-210	61	13	max	max	PROPN
admet-210	61	14	(	(	PUNCT
admet-210	61	15	λ	λ	NOUN
admet-210	61	16	)	)	PUNCT
admet-210	61	17	of	of	ADP
admet-210	61	18	individual	individual	ADJ
admet-210	61	19	well	well	ADV
admet-210	61	20	resolved	resolve	VERB
admet-210	61	21	chromatographic	chromatographic	ADJ
admet-210	61	22	peaks	peak	NOUN
admet-210	61	23	devoid	devoid	ADJ
admet-210	61	24	of	of	ADP
admet-210	61	25	interference	interference	NOUN
admet-210	61	26	.	.	PUNCT
admet-210	62	1	table	table	NOUN
admet-210	62	2	2	2	NUM
admet-210	62	3	shows	show	NOUN
admet-210	62	4	uv	uv	PROPN
admet-210	62	5	max	max	PROPN
admet-210	62	6	and	and	CCONJ
admet-210	62	7	retention	retention	NOUN
admet-210	62	8	time	time	NOUN
admet-210	62	9	(	(	PUNCT
admet-210	62	10	rt	rt	NOUN
admet-210	62	11	)	)	PUNCT
admet-210	62	12	of	of	ADP
admet-210	62	13	all	all	DET
admet-210	62	14	compounds	compound	NOUN
admet-210	62	15	.	.	PUNCT
admet-210	63	1	the	the	DET
admet-210	63	2	following	follow	VERB
admet-210	63	3	reactions	reaction	NOUN
admet-210	63	4	were	be	AUX
admet-210	63	5	monitored	monitor	VERB
admet-210	63	6	,	,	PUNCT
admet-210	63	7	phenacetin	phenacetin	NOUN
admet-210	63	8	-	-	PUNCT
admet-210	63	9	o	o	NOUN
admet-210	63	10	-	-	NOUN
admet-210	63	11	deethylation	deethylation	NOUN
admet-210	63	12	as	as	ADP
admet-210	63	13	marker	marker	NOUN
admet-210	63	14	reaction	reaction	NOUN
admet-210	63	15	of	of	ADP
admet-210	63	16	cyp1a2	cyp1a2	PROPN
admet-210	63	17	,	,	PUNCT
admet-210	63	18	diclofenac-4	diclofenac-4	NOUN
admet-210	63	19	-	-	PUNCT
admet-210	63	20	hydroxylation	hydroxylation	NOUN
admet-210	63	21	as	as	ADP
admet-210	63	22	marker	marker	NOUN
admet-210	63	23	reaction	reaction	NOUN
admet-210	63	24	of	of	ADP
admet-210	63	25	cyp2c9	cyp2c9	NOUN
admet-210	63	26	,	,	PUNCT
admet-210	63	27	s	s	PROPN
admet-210	63	28	-	-	PUNCT
admet-210	63	29	mephenytoin-4	mephenytoin-4	NOUN
admet-210	63	30	-	-	PUNCT
admet-210	63	31	hydroxylation	hydroxylation	NOUN
admet-210	63	32	as	as	ADP
admet-210	63	33	marker	marker	NOUN
admet-210	63	34	reaction	reaction	NOUN
admet-210	63	35	of	of	ADP
admet-210	63	36	cyp2c19	cyp2c19	PROPN
admet-210	63	37	,	,	PUNCT
admet-210	63	38	dextromethorphan	dextromethorphan	PROPN
admet-210	63	39	-	-	PUNCT
admet-210	63	40	o	o	NOUN
admet-210	63	41	-	-	NOUN
admet-210	63	42	demethylation	demethylation	NOUN
admet-210	63	43	as	as	ADP
admet-210	63	44	marker	marker	NOUN
admet-210	63	45	reaction	reaction	NOUN
admet-210	63	46	of	of	ADP
admet-210	63	47	cyp2d6	cyp2d6	NOUN
admet-210	63	48	,	,	PUNCT
admet-210	63	49	nifedipine	nifedipine	NOUN
admet-210	63	50	admet	admet	PROPN
admet-210	63	51	&	&	CCONJ
admet-210	63	52	dmpk	dmpk	PROPN
admet-210	63	53	4(2	4(2	NUM
admet-210	63	54	)	)	PUNCT
admet-210	63	55	(	(	PUNCT
admet-210	63	56	2016	2016	NUM
admet-210	63	57	)	)	PUNCT
admet-210	63	58	84	84	NUM
admet-210	63	59	-	-	SYM
admet-210	63	60	90	90	NUM
admet-210	63	61	cyp	cyp	ADJ
admet-210	63	62	substrates	substrate	NOUN
admet-210	63	63	in	in	ADP
admet-210	63	64	fetal	fetal	ADJ
admet-210	63	65	hepatocytes	hepatocyte	NOUN
admet-210	63	66	doi	doi	NOUN
admet-210	63	67	:	:	PUNCT
admet-210	63	68	10.5599	10.5599	NUM
admet-210	63	69	/	/	SYM
admet-210	63	70	admet.4.2.210	admet.4.2.210	PROPN
admet-210	63	71	87	87	NUM
admet-210	63	72	oxidation	oxidation	NOUN
admet-210	63	73	as	as	ADP
admet-210	63	74	marker	marker	NOUN
admet-210	63	75	reaction	reaction	NOUN
admet-210	63	76	of	of	ADP
admet-210	63	77	cyp3a4	cyp3a4	NOUN
admet-210	63	78	,	,	PUNCT
admet-210	63	79	and	and	CCONJ
admet-210	63	80	testosterone	testosterone	NOUN
admet-210	63	81	6	6	NUM
admet-210	63	82	β	β	NOUN
admet-210	63	83	-	-	NOUN
admet-210	63	84	hydroxylation	hydroxylation	NOUN
admet-210	63	85	as	as	ADP
admet-210	63	86	marker	marker	NOUN
admet-210	63	87	reaction	reaction	NOUN
admet-210	63	88	of	of	ADP
admet-210	63	89	cyp3a4	cyp3a4	PROPN
admet-210	63	90	to	to	PART
admet-210	63	91	confirm	confirm	VERB
admet-210	63	92	the	the	DET
admet-210	63	93	metabolism	metabolism	NOUN
admet-210	63	94	by	by	ADP
admet-210	63	95	the	the	DET
admet-210	63	96	respective	respective	ADJ
admet-210	63	97	cyps	cyps	PROPN
admet-210	63	98	.	.	PUNCT
admet-210	64	1	comparison	comparison	NOUN
admet-210	64	2	of	of	ADP
admet-210	64	3	area	area	NOUN
admet-210	64	4	ration	ration	NOUN
admet-210	64	5	between	between	ADP
admet-210	64	6	0	0	NUM
admet-210	64	7	h	h	NOUN
admet-210	64	8	which	which	PRON
admet-210	64	9	was	be	AUX
admet-210	64	10	considered	consider	VERB
admet-210	64	11	as	as	ADP
admet-210	64	12	100	100	NUM
admet-210	64	13	%	%	NOUN
admet-210	64	14	against	against	ADP
admet-210	64	15	2	2	NUM
admet-210	64	16	h	h	NOUN
admet-210	64	17	samples	sample	NOUN
admet-210	64	18	resulted	result	VERB
admet-210	64	19	in	in	ADP
admet-210	64	20	,	,	PUNCT
admet-210	64	21	68.2	68.2	NUM
admet-210	64	22	±	±	NUM
admet-210	64	23	8.13	8.13	NUM
admet-210	64	24	%	%	NOUN
admet-210	64	25	,	,	PUNCT
admet-210	64	26	50.5	50.5	NUM
admet-210	64	27	±	±	NUM
admet-210	64	28	4.29	4.29	NUM
admet-210	64	29	%	%	NOUN
admet-210	64	30	,	,	PUNCT
admet-210	64	31	79.8	79.8	NUM
admet-210	64	32	±	±	NUM
admet-210	64	33	6.11	6.11	NUM
admet-210	64	34	%	%	NOUN
admet-210	64	35	,	,	PUNCT
admet-210	64	36	72.2	72.2	NUM
admet-210	64	37	±	±	NUM
admet-210	64	38	6.12	6.12	NUM
admet-210	64	39	%	%	NOUN
admet-210	64	40	,	,	PUNCT
admet-210	64	41	1.32	1.32	NUM
admet-210	64	42	±	±	NUM
admet-210	64	43	0.21	0.21	NUM
admet-210	64	44	%	%	NOUN
admet-210	64	45	,	,	PUNCT
admet-210	64	46	and	and	CCONJ
admet-210	64	47	4.26	4.26	NUM
admet-210	64	48	±	±	NUM
admet-210	64	49	0.92	0.92	NUM
admet-210	64	50	%	%	NOUN
admet-210	64	51	respectively	respectively	ADV
admet-210	64	52	for	for	ADP
admet-210	64	53	phenacetin	phenacetin	NOUN
admet-210	64	54	,	,	PUNCT
admet-210	64	55	diclofenac	diclofenac	NOUN
admet-210	64	56	,	,	PUNCT
admet-210	64	57	s	s	NOUN
admet-210	64	58	-	-	PUNCT
admet-210	64	59	mephenytoin	mephenytoin	ADJ
admet-210	64	60	,	,	PUNCT
admet-210	64	61	dextromethorphan	dextromethorphan	PROPN
admet-210	64	62	,	,	PUNCT
admet-210	64	63	nifedipine	nifedipine	NOUN
admet-210	64	64	and	and	CCONJ
admet-210	64	65	testosterone	testosterone	NOUN
admet-210	64	66	respectively	respectively	ADV
admet-210	64	67	.	.	PUNCT
admet-210	65	1	the	the	DET
admet-210	65	2	results	result	NOUN
admet-210	65	3	are	be	AUX
admet-210	65	4	shown	show	VERB
admet-210	65	5	as	as	ADP
admet-210	65	6	mean	mean	NOUN
admet-210	65	7	of	of	ADP
admet-210	65	8	three	three	NUM
admet-210	65	9	independent	independent	ADJ
admet-210	65	10	experiments	experiment	NOUN
admet-210	65	11	with	with	ADP
admet-210	65	12	standard	standard	ADJ
admet-210	65	13	error	error	NOUN
admet-210	65	14	of	of	ADP
admet-210	65	15	mean	mean	NOUN
admet-210	65	16	.	.	PUNCT
admet-210	66	1	depletion	depletion	NOUN
admet-210	66	2	of	of	ADP
admet-210	66	3	all	all	DET
admet-210	66	4	the	the	DET
admet-210	66	5	substrates	substrate	NOUN
admet-210	66	6	indicates	indicate	VERB
admet-210	66	7	maturation	maturation	NOUN
admet-210	66	8	and	and	CCONJ
admet-210	66	9	involvement	involvement	NOUN
admet-210	66	10	of	of	ADP
admet-210	66	11	cyp1a2	cyp1a2	PROPN
admet-210	66	12	,	,	PUNCT
admet-210	66	13	cyp2c9	cyp2c9	PROPN
admet-210	66	14	,	,	PUNCT
admet-210	66	15	cyp2c19	cyp2c19	PROPN
admet-210	66	16	,	,	PUNCT
admet-210	66	17	cyp2d6	cyp2d6	NOUN
admet-210	66	18	,	,	PUNCT
admet-210	66	19	and	and	CCONJ
admet-210	66	20	cyp3a4	cyp3a4	NOUN
admet-210	66	21	in	in	ADP
admet-210	66	22	fetal	fetal	ADJ
admet-210	66	23	liver	liver	NOUN
admet-210	66	24	.	.	PUNCT
admet-210	67	1	cyp3a4	cyp3a4	PROPN
admet-210	67	2	showed	show	VERB
admet-210	67	3	maximum	maximum	ADJ
admet-210	67	4	activity	activity	NOUN
admet-210	67	5	,	,	PUNCT
admet-210	67	6	resulting	result	VERB
admet-210	67	7	in	in	ADP
admet-210	67	8	more	more	ADJ
admet-210	67	9	than	than	ADP
admet-210	67	10	90	90	NUM
admet-210	67	11	%	%	NOUN
admet-210	67	12	depletion	depletion	NOUN
admet-210	67	13	of	of	ADP
admet-210	67	14	both	both	CCONJ
admet-210	67	15	the	the	DET
admet-210	67	16	cyp	cyp	ADJ
admet-210	67	17	3a4	3a4	NUM
admet-210	67	18	substrates	substrate	NOUN
admet-210	67	19	nifedipine	nifedipine	NOUN
admet-210	67	20	as	as	ADV
admet-210	67	21	well	well	ADV
admet-210	67	22	as	as	ADP
admet-210	67	23	testosterone	testosterone	NOUN
admet-210	67	24	,	,	PUNCT
admet-210	67	25	followed	follow	VERB
admet-210	67	26	by	by	ADP
admet-210	67	27	50	50	NUM
admet-210	67	28	%	%	NOUN
admet-210	67	29	depletion	depletion	NOUN
admet-210	67	30	of	of	ADP
admet-210	67	31	diclofenac	diclofenac	NOUN
admet-210	67	32	,	,	PUNCT
admet-210	67	33	32	32	NUM
admet-210	67	34	%	%	NOUN
admet-210	67	35	depletion	depletion	NOUN
admet-210	67	36	of	of	ADP
admet-210	67	37	phenacetin	phenacetin	NOUN
admet-210	67	38	,	,	PUNCT
admet-210	67	39	28	28	NUM
admet-210	67	40	%	%	NOUN
admet-210	67	41	depletion	depletion	NOUN
admet-210	67	42	of	of	ADP
admet-210	67	43	dextromethorphan	dextromethorphan	PROPN
admet-210	67	44	and	and	CCONJ
admet-210	67	45	20	20	NUM
admet-210	67	46	%	%	NOUN
admet-210	67	47	depletion	depletion	NOUN
admet-210	67	48	of	of	ADP
admet-210	67	49	s	s	NOUN
admet-210	67	50	-	-	NOUN
admet-210	67	51	mephenytoin	mephenytoin	NOUN
admet-210	67	52	.	.	PUNCT
admet-210	68	1	these	these	DET
admet-210	68	2	results	result	NOUN
admet-210	68	3	clearly	clearly	ADV
admet-210	68	4	suggest	suggest	VERB
admet-210	68	5	the	the	DET
admet-210	68	6	maturation	maturation	NOUN
admet-210	68	7	and	and	CCONJ
admet-210	68	8	involvement	involvement	NOUN
admet-210	68	9	of	of	ADP
admet-210	68	10	5	5	NUM
admet-210	68	11	different	different	ADJ
admet-210	68	12	cyps	cyp	NOUN
admet-210	68	13	in	in	ADP
admet-210	68	14	metabolism	metabolism	NOUN
admet-210	68	15	through	through	ADP
admet-210	68	16	human	human	ADJ
admet-210	68	17	foetus	foetus	NOUN
admet-210	68	18	.	.	PUNCT
admet-210	69	1	due	due	ADP
admet-210	69	2	to	to	ADP
admet-210	69	3	limitation	limitation	NOUN
admet-210	69	4	in	in	ADP
admet-210	69	5	availability	availability	NOUN
admet-210	69	6	of	of	ADP
admet-210	69	7	fetal	fetal	ADJ
admet-210	69	8	tissue	tissue	NOUN
admet-210	69	9	other	other	ADJ
admet-210	69	10	substrates	substrate	NOUN
admet-210	69	11	can	can	AUX
admet-210	69	12	not	not	PART
admet-210	69	13	be	be	AUX
admet-210	69	14	evaluated	evaluate	VERB
admet-210	69	15	.	.	PUNCT
admet-210	70	1	furthermore	furthermore	ADV
admet-210	70	2	,	,	PUNCT
admet-210	70	3	studies	study	NOUN
admet-210	70	4	to	to	PART
admet-210	70	5	evaluate	evaluate	VERB
admet-210	70	6	the	the	DET
admet-210	70	7	kinetic	kinetic	ADJ
admet-210	70	8	parameters	parameter	NOUN
admet-210	70	9	to	to	PART
admet-210	70	10	generate	generate	VERB
admet-210	70	11	km	km	NOUN
admet-210	70	12	and	and	CCONJ
admet-210	70	13	vmax	vmax	PROPN
admet-210	70	14	of	of	ADP
admet-210	70	15	each	each	DET
admet-210	70	16	cyp	cyp	ADJ
admet-210	70	17	using	use	VERB
admet-210	70	18	a	a	DET
admet-210	70	19	probe	probe	NOUN
admet-210	70	20	substrate	substrate	NOUN
admet-210	70	21	will	will	AUX
admet-210	70	22	be	be	AUX
admet-210	70	23	beneficial	beneficial	ADJ
admet-210	70	24	for	for	ADP
admet-210	70	25	the	the	DET
admet-210	70	26	regulatory	regulatory	ADJ
admet-210	70	27	authorities	authority	NOUN
admet-210	70	28	and	and	CCONJ
admet-210	70	29	clinicians	clinician	NOUN
admet-210	70	30	to	to	PART
admet-210	70	31	optimize	optimize	VERB
admet-210	70	32	the	the	DET
admet-210	70	33	dose	dose	NOUN
admet-210	70	34	and	and	CCONJ
admet-210	70	35	prevent	prevent	VERB
admet-210	70	36	drug	drug	NOUN
admet-210	70	37	-	-	PUNCT
admet-210	70	38	drug	drug	NOUN
admet-210	70	39	interactions	interaction	NOUN
admet-210	70	40	in	in	ADP
admet-210	70	41	pregnant	pregnant	ADJ
admet-210	70	42	women	woman	NOUN
admet-210	70	43	and	and	CCONJ
admet-210	70	44	neonates	neonate	NOUN
admet-210	70	45	.	.	PUNCT
admet-210	71	1	table	table	NOUN
admet-210	71	2	1	1	NUM
admet-210	71	3	.	.	PUNCT
admet-210	72	1	gradient	gradient	ADJ
admet-210	72	2	time	time	NOUN
admet-210	72	3	program	program	NOUN
admet-210	72	4	for	for	ADP
admet-210	72	5	hplc	hplc	NOUN
admet-210	72	6	with	with	ADP
admet-210	72	7	uv	uv	NOUN
admet-210	72	8	detection	detection	NOUN
admet-210	72	9	with	with	ADP
admet-210	72	10	ternary	ternary	ADJ
admet-210	72	11	gradient	gradient	ADJ
admet-210	72	12	mobile	mobile	ADJ
admet-210	72	13	phase	phase	NOUN
admet-210	72	14	,	,	PUNCT
admet-210	72	15	method	method	NOUN
admet-210	72	16	was	be	AUX
admet-210	72	17	reproduced	reproduce	VERB
admet-210	72	18	from	from	ADP
admet-210	72	19	rao	rao	PROPN
admet-210	72	20	et	et	PROPN
admet-210	72	21	.	.	PUNCT
admet-210	73	1	al	al	PROPN
admet-210	73	2	.	.	PUNCT
admet-210	74	1	[	[	X
admet-210	74	2	18	18	NUM
admet-210	74	3	]	]	PUNCT
admet-210	74	4	.	.	PUNCT
admet-210	74	5	time	time	NOUN
admet-210	74	6	,	,	PUNCT
admet-210	74	7	min	min	NOUN
admet-210	74	8	flow	flow	NOUN
admet-210	74	9	,	,	PUNCT
admet-210	74	10	ml	ml	PROPN
admet-210	74	11	/	/	SYM
admet-210	74	12	min	min	NOUN
admet-210	74	13	%	%	INTJ
admet-210	74	14	a	a	DET
admet-210	74	15	%	%	NOUN
admet-210	74	16	b	b	NOUN
admet-210	75	1	%	%	NOUN
admet-210	75	2	c	c	NOUN
admet-210	75	3	0	0	NUM
admet-210	75	4	1	1	NUM
admet-210	75	5	100	100	NUM
admet-210	75	6	0	0	NUM
admet-210	75	7	0	0	NUM
admet-210	75	8	2	2	NUM
admet-210	75	9	1	1	NUM
admet-210	75	10	90	90	NUM
admet-210	75	11	0	0	NUM
admet-210	75	12	10	10	NUM
admet-210	75	13	9	9	NUM
admet-210	75	14	1	1	NUM
admet-210	75	15	50	50	NUM
admet-210	75	16	20	20	NUM
admet-210	75	17	30	30	NUM
admet-210	75	18	12	12	NUM
admet-210	75	19	1	1	NUM
admet-210	75	20	50	50	NUM
admet-210	75	21	25	25	NUM
admet-210	75	22	25	25	NUM
admet-210	75	23	25	25	NUM
admet-210	75	24	1	1	NUM
admet-210	75	25	30	30	NUM
admet-210	75	26	50	50	NUM
admet-210	75	27	20	20	NUM
admet-210	75	28	28	28	NUM
admet-210	75	29	1	1	NUM
admet-210	75	30	10	10	NUM
admet-210	75	31	85	85	NUM
admet-210	75	32	5	5	NUM
admet-210	75	33	35	35	NUM
admet-210	75	34	1	1	NUM
admet-210	75	35	10	10	NUM
admet-210	75	36	85	85	NUM
admet-210	75	37	5	5	NUM
admet-210	75	38	36	36	NUM
admet-210	75	39	1	1	NUM
admet-210	75	40	100	100	NUM
admet-210	75	41	0	0	NUM
admet-210	75	42	0	0	NUM
admet-210	75	43	40	40	NUM
admet-210	75	44	1	1	NUM
admet-210	75	45	100	100	NUM
admet-210	75	46	0	0	NUM
admet-210	75	47	0	0	NUM
admet-210	76	1	a	a	DET
admet-210	76	2	=	=	ADJ
admet-210	76	3	90:10	90:10	NUM
admet-210	76	4	:	:	PUNCT
admet-210	76	5	:	:	PUNCT
admet-210	76	6	10	10	NUM
admet-210	76	7	µm	µm	NUM
admet-210	76	8	ammonium	ammonium	NOUN
admet-210	76	9	acetate	acetate	NOUN
admet-210	76	10	:	:	PUNCT
admet-210	76	11	acetonitrile	acetonitrile	NOUN
admet-210	76	12	,	,	PUNCT
admet-210	76	13	b	b	PROPN
admet-210	76	14	=	=	SYM
admet-210	76	15	5:95	5:95	NUM
admet-210	76	16	:	:	PUNCT
admet-210	76	17	:	:	PUNCT
admet-210	76	18	10	10	NUM
admet-210	76	19	µm	µm	NUM
admet-210	76	20	ammonium	ammonium	NOUN
admet-210	76	21	acetate	acetate	NOUN
admet-210	76	22	:	:	PUNCT
admet-210	76	23	acetonitrile	acetonitrile	NOUN
admet-210	76	24	,	,	PUNCT
admet-210	76	25	and	and	CCONJ
admet-210	76	26	c	c	X
admet-210	76	27	=	=	PROPN
admet-210	76	28	5:95	5:95	NUM
admet-210	76	29	:	:	PUNCT
admet-210	76	30	:	:	PUNCT
admet-210	76	31	10	10	NUM
admet-210	76	32	µm	µm	NUM
admet-210	76	33	ammonium	ammonium	NOUN
admet-210	76	34	acetate	acetate	NOUN
admet-210	76	35	:	:	PUNCT
admet-210	76	36	methanol	methanol	NOUN
admet-210	76	37	table	table	NOUN
admet-210	76	38	2	2	NUM
admet-210	76	39	.	.	PUNCT
admet-210	76	40	retention	retention	NOUN
admet-210	76	41	times	time	NOUN
admet-210	76	42	and	and	CCONJ
admet-210	76	43	uv	uv	NOUN
admet-210	76	44	max	max	PROPN
admet-210	76	45	(	(	PUNCT
admet-210	76	46	λ	λ	PROPN
admet-210	76	47	max	max	PROPN
admet-210	76	48	)	)	PUNCT
admet-210	76	49	of	of	ADP
admet-210	76	50	cyp	cyp	ADJ
admet-210	76	51	probe	probe	NOUN
admet-210	76	52	substrates	substrate	NOUN
admet-210	76	53	,	,	PUNCT
admet-210	76	54	their	their	PRON
admet-210	76	55	metabolites	metabolite	NOUN
admet-210	76	56	and	and	CCONJ
admet-210	76	57	internal	internal	ADJ
admet-210	76	58	standard	standard	NOUN
admet-210	76	59	.	.	PUNCT
admet-210	77	1	compound	compound	NOUN
admet-210	77	2	uv	uv	NOUN
admet-210	77	3	extracted	extract	VERB
admet-210	77	4	,	,	PUNCT
admet-210	77	5	nm	nm	INTJ
admet-210	77	6	,	,	PUNCT
admet-210	77	7	retention	retention	NOUN
admet-210	77	8	time	time	NOUN
admet-210	77	9	,	,	PUNCT
admet-210	77	10	min	min	PROPN
admet-210	77	11	phenacetin	phenacetin	VERB
admet-210	77	12	240	240	NUM
admet-210	77	13	14.1	14.1	NUM
admet-210	77	14	paracetamol	paracetamol	NOUN
admet-210	77	15	240	240	NUM
admet-210	77	16	7.1	7.1	NUM
admet-210	77	17	diclofenac	diclofenac	NOUN
admet-210	77	18	280	280	NUM
admet-210	77	19	24.9	24.9	NUM
admet-210	77	20	4	4	NUM
admet-210	77	21	-	-	PUNCT
admet-210	77	22	hydrxoydiclofenac	hydrxoydiclofenac	NOUN
admet-210	77	23	280	280	NUM
admet-210	77	24	18.7	18.7	NUM
admet-210	77	25	s	s	NOUN
admet-210	77	26	-	-	PUNCT
admet-210	77	27	mephenytoin	mephenytoin	NOUN
admet-210	77	28	250	250	NUM
admet-210	77	29	15.9	15.9	NUM
admet-210	77	30	4	4	NUM
admet-210	77	31	-	-	PUNCT
admet-210	77	32	hydroxymephenytoin	hydroxymephenytoin	NOUN
admet-210	77	33	250	250	NUM
admet-210	77	34	11.5	11.5	NUM
admet-210	77	35	dextromethorphan	dextromethorphan	NOUN
admet-210	77	36	277	277	NUM
admet-210	77	37	14.3	14.3	NUM
admet-210	77	38	dextrorphan	dextrorphan	NOUN
admet-210	77	39	277	277	NUM
admet-210	77	40	10.3	10.3	NUM
admet-210	77	41	nifedipine	nifedipine	NOUN
admet-210	77	42	240	240	NUM
admet-210	77	43	22.9	22.9	NUM
admet-210	77	44	hydroxynifedipine	hydroxynifedipine	NOUN
admet-210	77	45	240	240	NUM
admet-210	77	46	21.2	21.2	NUM
admet-210	77	47	testosterone	testosterone	NOUN
admet-210	77	48	240	240	NUM
admet-210	77	49	24.4	24.4	NUM
admet-210	77	50	6β	6β	NUM
admet-210	77	51	-	-	PUNCT
admet-210	77	52	hydroxytestosterone	hydroxytestosterone	NOUN
admet-210	77	53	240	240	NUM
admet-210	77	54	15.7	15.7	NUM
admet-210	77	55	celecoxib	celecoxib	VERB
admet-210	77	56	250	250	NUM
admet-210	77	57	30.1	30.1	NUM
admet-210	77	58	shaik	shaik	NOUN
admet-210	77	59	et	et	PROPN
admet-210	77	60	al	al	PROPN
admet-210	77	61	.	.	PROPN
admet-210	77	62	admet	admet	PROPN
admet-210	77	63	&	&	CCONJ
admet-210	77	64	dmpk	dmpk	PROPN
admet-210	77	65	4(2	4(2	NUM
admet-210	77	66	)	)	PUNCT
admet-210	77	67	(	(	PUNCT
admet-210	77	68	2016	2016	NUM
admet-210	77	69	)	)	PUNCT
admet-210	77	70	84	84	NUM
admet-210	77	71	-	-	SYM
admet-210	77	72	90	90	NUM
admet-210	77	73	88	88	NUM
admet-210	77	74	figure	figure	NOUN
admet-210	77	75	1	1	NUM
admet-210	77	76	.	.	PUNCT
admet-210	78	1	a	a	DET
admet-210	78	2	10	10	NUM
admet-210	78	3	x	x	SYM
admet-210	78	4	microscopic	microscopic	ADJ
admet-210	78	5	image	image	NOUN
admet-210	78	6	of	of	ADP
admet-210	78	7	the	the	DET
admet-210	78	8	well	well	ADV
admet-210	78	9	differentiated	differentiated	ADJ
admet-210	78	10	hepatocytes	hepatocyte	NOUN
admet-210	78	11	of	of	ADP
admet-210	78	12	human	human	ADJ
admet-210	78	13	origin	origin	NOUN
admet-210	78	14	,	,	PUNCT
admet-210	78	15	obtained	obtain	VERB
admet-210	78	16	from	from	ADP
admet-210	78	17	14	14	NUM
admet-210	78	18	week	week	NOUN
admet-210	78	19	old	old	ADJ
admet-210	78	20	aborted	aborted	ADJ
admet-210	78	21	foetus	foetus	NOUN
admet-210	78	22	.	.	PUNCT
admet-210	79	1	figure	figure	NOUN
admet-210	79	2	2	2	NUM
admet-210	79	3	.	.	PUNCT
admet-210	79	4	metabolism	metabolism	NOUN
admet-210	79	5	of	of	ADP
admet-210	79	6	six	six	NUM
admet-210	79	7	cyp	cyp	ADJ
admet-210	79	8	probe	probe	NOUN
admet-210	79	9	substrates	substrate	NOUN
admet-210	79	10	,	,	PUNCT
admet-210	79	11	the	the	DET
admet-210	79	12	bars	bar	NOUN
admet-210	79	13	represent	represent	VERB
admet-210	79	14	mean	mean	NOUN
admet-210	79	15	of	of	ADP
admet-210	79	16	percent	percent	NOUN
admet-210	79	17	remaining	remain	VERB
admet-210	79	18	of	of	ADP
admet-210	79	19	the	the	DET
admet-210	79	20	drug	drug	NOUN
admet-210	79	21	after	after	SCONJ
admet-210	79	22	2	2	NUM
admet-210	79	23	h	h	NOUN
admet-210	79	24	obtained	obtain	VERB
admet-210	79	25	from	from	ADP
admet-210	79	26	three	three	NUM
admet-210	79	27	independent	independent	ADJ
admet-210	79	28	experiments	experiment	NOUN
admet-210	79	29	,	,	PUNCT
admet-210	79	30	the	the	DET
admet-210	79	31	bars	bar	NOUN
admet-210	79	32	represent	represent	VERB
admet-210	79	33	standard	standard	ADJ
admet-210	79	34	error	error	NOUN
admet-210	79	35	of	of	ADP
admet-210	79	36	mean	mean	ADJ
admet-210	79	37	.	.	PUNCT
admet-210	80	1	conclusions	conclusion	NOUN
admet-210	80	2	in	in	ADP
admet-210	80	3	conclusion	conclusion	NOUN
admet-210	80	4	,	,	PUNCT
admet-210	80	5	fetal	fetal	ADJ
admet-210	80	6	hepatocytes	hepatocyte	NOUN
admet-210	80	7	were	be	AUX
admet-210	80	8	successfully	successfully	ADV
admet-210	80	9	isolated	isolate	VERB
admet-210	80	10	from	from	ADP
admet-210	80	11	different	different	ADJ
admet-210	80	12	subjects	subject	NOUN
admet-210	80	13	with	with	ADP
admet-210	80	14	viability	viability	NOUN
admet-210	80	15	of	of	ADP
admet-210	80	16	greater	great	ADJ
admet-210	80	17	than	than	ADP
admet-210	80	18	80	80	NUM
admet-210	80	19	%	%	NOUN
admet-210	80	20	using	use	VERB
admet-210	80	21	earlier	early	ADV
admet-210	80	22	reported	report	VERB
admet-210	80	23	method	method	NOUN
admet-210	80	24	[	[	X
admet-210	80	25	17	17	NUM
admet-210	80	26	]	]	PUNCT
admet-210	80	27	.	.	PUNCT
admet-210	81	1	these	these	DET
admet-210	81	2	cells	cell	NOUN
admet-210	81	3	were	be	AUX
admet-210	81	4	used	use	VERB
admet-210	81	5	to	to	PART
admet-210	81	6	perform	perform	VERB
admet-210	81	7	the	the	DET
admet-210	81	8	metabolism	metabolism	NOUN
admet-210	81	9	studies	study	NOUN
admet-210	81	10	of	of	ADP
admet-210	81	11	six	six	NUM
admet-210	81	12	probe	probe	NOUN
admet-210	81	13	cyp	cyp	ADJ
admet-210	81	14	substrates	substrate	NOUN
admet-210	81	15	,	,	PUNCT
admet-210	81	16	using	use	VERB
admet-210	81	17	parent	parent	NOUN
admet-210	81	18	depletion	depletion	NOUN
admet-210	81	19	approach	approach	NOUN
admet-210	81	20	[	[	X
admet-210	81	21	19	19	NUM
admet-210	81	22	,	,	PUNCT
admet-210	81	23	27	27	NUM
admet-210	81	24	]	]	PUNCT
admet-210	81	25	.	.	PUNCT
admet-210	82	1	the	the	DET
admet-210	82	2	results	result	NOUN
admet-210	82	3	obtained	obtain	VERB
admet-210	82	4	by	by	ADP
admet-210	82	5	the	the	DET
admet-210	82	6	commonly	commonly	ADV
admet-210	82	7	used	use	VERB
admet-210	82	8	substrate	substrate	NOUN
admet-210	82	9	depletion	depletion	NOUN
admet-210	82	10	approach	approach	NOUN
admet-210	82	11	[	[	X
admet-210	82	12	19	19	NUM
admet-210	82	13	,	,	PUNCT
admet-210	82	14	28	28	NUM
admet-210	82	15	,	,	PUNCT
admet-210	82	16	29	29	NUM
admet-210	82	17	]	]	PUNCT
admet-210	82	18	prove	prove	VERB
admet-210	82	19	differentiation	differentiation	NOUN
admet-210	82	20	,	,	PUNCT
admet-210	82	21	maturation	maturation	NOUN
admet-210	82	22	and	and	CCONJ
admet-210	82	23	involvement	involvement	NOUN
admet-210	82	24	of	of	ADP
admet-210	82	25	five	five	NUM
admet-210	82	26	cyps	cyp	NOUN
admet-210	82	27	(	(	PUNCT
admet-210	82	28	cyp1a2	cyp1a2	PROPN
admet-210	82	29	,	,	PUNCT
admet-210	82	30	cyp2c9	cyp2c9	PROPN
admet-210	82	31	,	,	PUNCT
admet-210	82	32	cyp2c19	cyp2c19	PROPN
admet-210	82	33	,	,	PUNCT
admet-210	82	34	cyp2d6	cyp2d6	NOUN
admet-210	82	35	,	,	PUNCT
admet-210	82	36	and	and	CCONJ
admet-210	82	37	cyp3a4	cyp3a4	PROPN
admet-210	82	38	)	)	PUNCT
admet-210	82	39	in	in	ADP
admet-210	82	40	clearance	clearance	NOUN
admet-210	82	41	of	of	ADP
admet-210	82	42	phenacetin	phenacetin	NOUN
admet-210	82	43	,	,	PUNCT
admet-210	82	44	diclofenac	diclofenac	NOUN
admet-210	82	45	,	,	PUNCT
admet-210	82	46	s	s	NOUN
admet-210	82	47	-	-	PUNCT
admet-210	82	48	mepheytoin	mepheytoin	ADJ
admet-210	82	49	,	,	PUNCT
admet-210	82	50	dextromethorphan	dextromethorphan	PROPN
admet-210	82	51	,	,	PUNCT
admet-210	82	52	nifedipine	nifedipine	NOUN
admet-210	82	53	and	and	CCONJ
admet-210	82	54	testosterone	testosterone	NOUN
admet-210	82	55	from	from	ADP
admet-210	82	56	the	the	DET
admet-210	82	57	fetal	fetal	ADJ
admet-210	82	58	liver	liver	NOUN
admet-210	82	59	.	.	PUNCT
admet-210	83	1	furthermore	furthermore	ADV
admet-210	83	2	,	,	PUNCT
admet-210	83	3	the	the	DET
admet-210	83	4	percent	percent	NOUN
admet-210	83	5	depletion	depletion	NOUN
admet-210	83	6	of	of	ADP
admet-210	83	7	testosterone	testosterone	NOUN
admet-210	83	8	and	and	CCONJ
admet-210	83	9	nifedipine	nifedipine	NOUN
admet-210	83	10	is	be	AUX
admet-210	83	11	similar	similar	ADJ
admet-210	83	12	to	to	ADP
admet-210	83	13	adults	adult	NOUN
admet-210	83	14	(	(	PUNCT
admet-210	83	15	data	datum	NOUN
admet-210	83	16	not	not	PART
admet-210	83	17	shown	show	VERB
admet-210	83	18	)	)	PUNCT
admet-210	84	1	%	%	NOUN
admet-210	85	1	p	p	NOUN
admet-210	85	2	a	a	DET
admet-210	85	3	r	r	NOUN
admet-210	85	4	e	e	NOUN
admet-210	85	5	n	n	NOUN
admet-210	85	6	t	t	NOUN
admet-210	85	7	r	r	NOUN
admet-210	85	8	e	e	X
admet-210	85	9	m	m	VERB
admet-210	85	10	a	a	PRON
admet-210	85	11	in	in	ADV
admet-210	85	12	in	in	ADP
admet-210	85	13	g	g	PROPN
admet-210	85	14	d	d	X
admet-210	85	15	e	e	X
admet-210	85	16	x	x	PUNCT
admet-210	85	17	tr	tr	PUNCT
admet-210	85	18	o	o	NOUN
admet-210	85	19	m	m	NOUN
admet-210	85	20	e	e	NOUN
admet-210	85	21	to	to	ADP
admet-210	85	22	rp	rp	NOUN
admet-210	85	23	h	h	NOUN
admet-210	85	24	a	a	DET
admet-210	85	25	n	n	NOUN
admet-210	86	1	d	d	NOUN
admet-210	86	2	ic	ic	PROPN
admet-210	86	3	lo	lo	PROPN
admet-210	86	4	fe	fe	PROPN
admet-210	86	5	n	n	CCONJ
admet-210	86	6	a	a	DET
admet-210	86	7	c	c	NOUN
admet-210	86	8	m	m	NOUN
admet-210	86	9	e	e	NOUN
admet-210	86	10	p	p	NOUN
admet-210	86	11	h	h	PROPN
admet-210	86	12	e	e	PROPN
admet-210	86	13	n	n	ADP
admet-210	86	14	y	y	PROPN
admet-210	86	15	to	to	PART
admet-210	86	16	in	in	ADP
admet-210	86	17	p	p	NOUN
admet-210	86	18	h	h	NOUN
admet-210	86	19	e	e	NOUN
admet-210	86	20	n	n	CCONJ
admet-210	86	21	a	a	PRON
admet-210	86	22	c	c	NOUN
admet-210	86	23	e	e	NOUN
admet-210	86	24	t	t	NOUN
admet-210	87	1	i	i	PRON
admet-210	87	2	n	n	CCONJ
admet-210	87	3	n	n	ADV
admet-210	87	4	if	if	SCONJ
admet-210	87	5	e	e	X
admet-210	87	6	d	d	NOUN
admet-210	87	7	ip	ip	NOUN
admet-210	87	8	in	in	ADP
admet-210	87	9	e	e	PROPN
admet-210	87	10	t	t	PROPN
admet-210	87	11	e	e	NOUN
admet-210	87	12	s	s	NOUN
admet-210	87	13	to	to	PART
admet-210	87	14	s	s	PROPN
admet-210	87	15	te	te	PROPN
admet-210	87	16	ro	ro	X
admet-210	87	17	n	n	PROPN
admet-210	87	18	e	e	X
admet-210	87	19	0	0	NUM
admet-210	87	20	2	2	NUM
admet-210	87	21	0	0	NUM
admet-210	87	22	4	4	NUM
admet-210	87	23	0	0	NUM
admet-210	87	24	6	6	NUM
admet-210	87	25	0	0	NUM
admet-210	87	26	8	8	NUM
admet-210	87	27	0	0	NUM
admet-210	87	28	1	1	NUM
admet-210	87	29	0	0	NUM
admet-210	87	30	0	0	NUM
admet-210	87	31	admet	admet	PROPN
admet-210	87	32	&	&	CCONJ
admet-210	87	33	dmpk	dmpk	PROPN
admet-210	87	34	4(2	4(2	NUM
admet-210	87	35	)	)	PUNCT
admet-210	87	36	(	(	PUNCT
admet-210	87	37	2016	2016	NUM
admet-210	87	38	)	)	PUNCT
admet-210	87	39	84	84	NUM
admet-210	87	40	-	-	SYM
admet-210	87	41	90	90	NUM
admet-210	87	42	cyp	cyp	ADJ
admet-210	87	43	substrates	substrate	NOUN
admet-210	87	44	in	in	ADP
admet-210	87	45	fetal	fetal	ADJ
admet-210	87	46	hepatocytes	hepatocyte	NOUN
admet-210	87	47	doi	doi	NOUN
admet-210	87	48	:	:	PUNCT
admet-210	87	49	10.5599	10.5599	NUM
admet-210	87	50	/	/	SYM
admet-210	87	51	admet.4.2.210	admet.4.2.210	PROPN
admet-210	87	52	89	89	NUM
admet-210	87	53	suggesting	suggest	VERB
admet-210	87	54	well	well	ADJ
admet-210	87	55	differentiation	differentiation	NOUN
admet-210	87	56	of	of	ADP
admet-210	87	57	cyp3a4	cyp3a4	PROPN
admet-210	87	58	as	as	ADP
admet-210	87	59	compared	compare	VERB
admet-210	87	60	to	to	ADP
admet-210	87	61	other	other	ADJ
admet-210	87	62	cyps	cyp	NOUN
admet-210	87	63	which	which	PRON
admet-210	87	64	resulted	result	VERB
admet-210	87	65	in	in	ADP
admet-210	87	66	lesser	less	ADJ
admet-210	87	67	depletion	depletion	NOUN
admet-210	87	68	of	of	ADP
admet-210	87	69	other	other	ADJ
admet-210	87	70	substrates	substrate	NOUN
admet-210	87	71	.	.	PUNCT
admet-210	88	1	this	this	DET
admet-210	88	2	study	study	NOUN
admet-210	88	3	was	be	AUX
admet-210	88	4	limited	limit	VERB
admet-210	88	5	by	by	ADP
admet-210	88	6	the	the	DET
admet-210	88	7	availability	availability	NOUN
admet-210	88	8	of	of	ADP
admet-210	88	9	fetal	fetal	ADJ
admet-210	88	10	hepatocytes	hepatocyte	NOUN
admet-210	88	11	to	to	PART
admet-210	88	12	calculate	calculate	VERB
admet-210	88	13	the	the	DET
admet-210	88	14	intrinsic	intrinsic	ADJ
admet-210	88	15	clearance	clearance	NOUN
admet-210	88	16	(	(	PUNCT
admet-210	88	17	clint	clint	NOUN
admet-210	88	18	)	)	PUNCT
admet-210	88	19	commonly	commonly	ADV
admet-210	88	20	used	use	VERB
admet-210	88	21	to	to	PART
admet-210	88	22	represent	represent	VERB
admet-210	88	23	in	in	ADP
admet-210	88	24	vitro	vitro	X
admet-210	88	25	metabolism	metabolism	NOUN
admet-210	89	1	[	[	X
admet-210	89	2	30	30	NUM
admet-210	89	3	,	,	PUNCT
admet-210	89	4	31	31	NUM
admet-210	89	5	]	]	PUNCT
admet-210	89	6	,	,	PUNCT
admet-210	90	1	and	and	CCONJ
admet-210	90	2	determine	determine	VERB
admet-210	90	3	the	the	DET
admet-210	90	4	mrna	mrna	PROPN
admet-210	90	5	content	content	NOUN
admet-210	90	6	of	of	ADP
admet-210	90	7	cyp450	cyp450	NOUN
admet-210	90	8	for	for	ADP
admet-210	90	9	head	head	NOUN
admet-210	90	10	on	on	ADP
admet-210	90	11	comparison	comparison	NOUN
admet-210	90	12	with	with	ADP
admet-210	90	13	adult	adult	NOUN
admet-210	90	14	hepatocytes	hepatocyte	NOUN
admet-210	91	1	[	[	X
admet-210	91	2	32	32	NUM
admet-210	91	3	]	]	PUNCT
admet-210	91	4	,	,	PUNCT
admet-210	91	5	which	which	PRON
admet-210	91	6	will	will	AUX
admet-210	91	7	be	be	AUX
admet-210	91	8	helpful	helpful	ADJ
admet-210	91	9	in	in	ADP
admet-210	91	10	designing	design	VERB
admet-210	91	11	the	the	DET
admet-210	91	12	doses	dose	NOUN
admet-210	91	13	of	of	ADP
admet-210	91	14	different	different	ADJ
admet-210	91	15	drugs	drug	NOUN
admet-210	91	16	in	in	ADP
admet-210	91	17	pregnant	pregnant	ADJ
admet-210	91	18	women	woman	NOUN
admet-210	91	19	and	and	CCONJ
admet-210	91	20	neonates	neonate	NOUN
admet-210	91	21	.	.	PUNCT
admet-210	92	1	note	note	NOUN
admet-210	92	2	:	:	PUNCT
admet-210	92	3	abdul	abdul	PROPN
admet-210	92	4	naveed	naveed	PROPN
admet-210	92	5	shaik	shaik	PROPN
admet-210	92	6	’s	’s	PART
admet-210	92	7	current	current	ADJ
admet-210	92	8	affiliation	affiliation	NOUN
admet-210	92	9	:	:	PUNCT
admet-210	92	10	center	center	NOUN
admet-210	92	11	for	for	ADP
admet-210	92	12	pharmacometric	pharmacometric	ADJ
admet-210	92	13	and	and	CCONJ
admet-210	92	14	systems	system	NOUN
admet-210	92	15	pharmacology	pharmacology	NOUN
admet-210	92	16	,	,	PUNCT
admet-210	92	17	university	university	PROPN
admet-210	92	18	of	of	ADP
admet-210	92	19	florida	florida	PROPN
admet-210	92	20	,	,	PUNCT
admet-210	92	21	orlando	orlando	PROPN
admet-210	92	22	fl	fl	PROPN
admet-210	92	23	references	reference	NOUN
admet-210	92	24	[	[	X
admet-210	92	25	1	1	NUM
admet-210	92	26	]	]	X
admet-210	92	27	u.m	u.m	PROPN
admet-210	92	28	.	.	PROPN
admet-210	92	29	zanger	zanger	NOUN
admet-210	92	30	,	,	PUNCT
admet-210	92	31	m.	m.	NOUN
admet-210	92	32	schwab	schwab	PROPN
admet-210	92	33	,	,	PUNCT
admet-210	92	34	pharmacology	pharmacology	NOUN
admet-210	92	35	&	&	CCONJ
admet-210	92	36	therapeutics	therapeutic	NOUN
admet-210	92	37	138	138	NUM
admet-210	92	38	(	(	PUNCT
admet-210	92	39	2013	2013	NUM
admet-210	92	40	)	)	PUNCT
admet-210	92	41	103	103	NUM
admet-210	92	42	-	-	SYM
admet-210	92	43	141	141	NUM
admet-210	92	44	.	.	PUNCT
admet-210	93	1	[	[	X
admet-210	93	2	2	2	X
admet-210	93	3	]	]	X
admet-210	93	4	j.h	j.h	PROPN
admet-210	93	5	.	.	PROPN
admet-210	93	6	ansede	ansede	PROPN
admet-210	93	7	,	,	PUNCT
admet-210	93	8	d.r	d.r	PROPN
admet-210	93	9	.	.	PROPN
admet-210	93	10	thakker	thakker	PROPN
admet-210	93	11	,	,	PUNCT
admet-210	93	12	journal	journal	NOUN
admet-210	93	13	of	of	ADP
admet-210	93	14	pharmaceutical	pharmaceutical	ADJ
admet-210	93	15	sciences	science	NOUN
admet-210	93	16	93	93	NUM
admet-210	93	17	(	(	PUNCT
admet-210	93	18	2004	2004	NUM
admet-210	93	19	)	)	PUNCT
admet-210	93	20	239	239	NUM
admet-210	93	21	-	-	SYM
admet-210	93	22	255	255	NUM
admet-210	93	23	.	.	PUNCT
admet-210	94	1	[	[	X
admet-210	94	2	3	3	X
admet-210	94	3	]	]	X
admet-210	94	4	j.	j.	PROPN
admet-210	94	5	george	george	PROPN
admet-210	94	6	,	,	PUNCT
admet-210	94	7	c.	c.	PROPN
admet-210	94	8	liddle	liddle	PROPN
admet-210	94	9	,	,	PUNCT
admet-210	94	10	m.	m.	NOUN
admet-210	94	11	murray	murray	PROPN
admet-210	94	12	,	,	PUNCT
admet-210	94	13	k.	k.	PROPN
admet-210	94	14	byth	byth	PROPN
admet-210	94	15	,	,	PUNCT
admet-210	94	16	g.c	g.c	PROPN
admet-210	94	17	.	.	PROPN
admet-210	94	18	farrell	farrell	PROPN
admet-210	94	19	,	,	PUNCT
admet-210	94	20	biochemical	biochemical	ADJ
admet-210	94	21	pharmacology	pharmacology	NOUN
admet-210	94	22	49	49	NUM
admet-210	94	23	(	(	PUNCT
admet-210	94	24	1995	1995	NUM
admet-210	94	25	)	)	PUNCT
admet-210	94	26	873	873	NUM
admet-210	94	27	-	-	NUM
admet-210	94	28	881	881	NUM
admet-210	94	29	.	.	PUNCT
admet-210	95	1	[	[	X
admet-210	95	2	4	4	NUM
admet-210	95	3	]	]	X
admet-210	95	4	a.s	a.s	PROPN
admet-210	95	5	.	.	PROPN
admet-210	95	6	kalgutkar	kalgutkar	PROPN
admet-210	95	7	,	,	PUNCT
admet-210	95	8	r.s	r.s	PROPN
admet-210	95	9	.	.	PROPN
admet-210	95	10	obach	obach	PROPN
admet-210	95	11	,	,	PUNCT
admet-210	95	12	t.s	t.s	PROPN
admet-210	95	13	.	.	PROPN
admet-210	95	14	maurer	maurer	PROPN
admet-210	95	15	,	,	PUNCT
admet-210	95	16	current	current	ADJ
admet-210	95	17	drug	drug	NOUN
admet-210	95	18	metabolism	metabolism	NOUN
admet-210	95	19	8	8	NUM
admet-210	95	20	(	(	PUNCT
admet-210	95	21	2007	2007	NUM
admet-210	95	22	)	)	PUNCT
admet-210	95	23	407	407	NUM
admet-210	95	24	-	-	SYM
admet-210	95	25	447	447	NUM
admet-210	95	26	.	.	PUNCT
admet-210	96	1	[	[	X
admet-210	96	2	5	5	NUM
admet-210	96	3	]	]	X
admet-210	96	4	s.c	s.c	PROPN
admet-210	96	5	.	.	PROPN
admet-210	96	6	preissner	preissner	PROPN
admet-210	96	7	,	,	PUNCT
admet-210	96	8	m.f	m.f	PROPN
admet-210	96	9	.	.	PUNCT
admet-210	97	1	hoffmann	hoffmann	PROPN
admet-210	97	2	,	,	PUNCT
admet-210	97	3	r.	r.	PROPN
admet-210	97	4	preissner	preissner	PROPN
admet-210	97	5	,	,	PUNCT
admet-210	97	6	m.	m.	NOUN
admet-210	97	7	dunkel	dunkel	NOUN
admet-210	97	8	,	,	PUNCT
admet-210	97	9	a.	a.	NOUN
admet-210	97	10	gewiess	gewiess	PROPN
admet-210	97	11	,	,	PUNCT
admet-210	97	12	s.	s.	PROPN
admet-210	97	13	preissner	preissner	PROPN
admet-210	97	14	,	,	PUNCT
admet-210	97	15	plos	plos	PROPN
admet-210	97	16	one	one	NUM
admet-210	97	17	8	8	NUM
admet-210	97	18	(	(	PUNCT
admet-210	97	19	2013	2013	NUM
admet-210	97	20	)	)	PUNCT
admet-210	97	21	e82562	e82562	NOUN
admet-210	97	22	.	.	PUNCT
admet-210	98	1	[	[	X
admet-210	98	2	6	6	NUM
admet-210	98	3	]	]	PUNCT
admet-210	98	4	b.	b.	PROPN
admet-210	98	5	krauer	krauer	PROPN
admet-210	98	6	,	,	PUNCT
admet-210	98	7	p.	p.	NOUN
admet-210	98	8	dayer	dayer	NOUN
admet-210	98	9	,	,	PUNCT
admet-210	98	10	clinical	clinical	ADJ
admet-210	98	11	pharmacokinetics	pharmacokinetic	NOUN
admet-210	98	12	21	21	NUM
admet-210	98	13	(	(	PUNCT
admet-210	98	14	1991	1991	NUM
admet-210	98	15	)	)	PUNCT
admet-210	98	16	70	70	NUM
admet-210	98	17	-	-	SYM
admet-210	98	18	80	80	NUM
admet-210	98	19	.	.	PUNCT
admet-210	99	1	[	[	X
admet-210	99	2	7	7	X
admet-210	99	3	]	]	X
admet-210	99	4	m.s	m.s	PROPN
admet-210	99	5	.	.	PROPN
admet-210	99	6	miller	miller	PROPN
admet-210	99	7	,	,	PUNCT
admet-210	99	8	m.r	m.r	PROPN
admet-210	99	9	.	.	PROPN
admet-210	99	10	juchau	juchau	PROPN
admet-210	99	11	,	,	PUNCT
admet-210	99	12	f.p	f.p	PROPN
admet-210	99	13	.	.	PROPN
admet-210	99	14	guengerich	guengerich	PROPN
admet-210	99	15	,	,	PUNCT
admet-210	99	16	d.w	d.w	PROPN
admet-210	99	17	.	.	PROPN
admet-210	99	18	nebert	nebert	PROPN
admet-210	99	19	,	,	PUNCT
admet-210	99	20	j.l	j.l	PROPN
admet-210	99	21	.	.	PROPN
admet-210	99	22	raucy	raucy	PROPN
admet-210	99	23	,	,	PUNCT
admet-210	99	24	fundamental	fundamental	ADJ
admet-210	99	25	and	and	CCONJ
admet-210	99	26	applied	applied	ADJ
admet-210	99	27	toxicology	toxicology	NOUN
admet-210	99	28	:	:	PUNCT
admet-210	99	29	official	official	ADJ
admet-210	99	30	journal	journal	NOUN
admet-210	99	31	of	of	ADP
admet-210	99	32	the	the	DET
admet-210	99	33	society	society	NOUN
admet-210	99	34	of	of	ADP
admet-210	99	35	toxicology	toxicology	NOUN
admet-210	99	36	34	34	NUM
admet-210	99	37	(	(	PUNCT
admet-210	99	38	1996	1996	NUM
admet-210	99	39	)	)	PUNCT
admet-210	99	40	165	165	NUM
admet-210	99	41	-	-	SYM
admet-210	99	42	175	175	NUM
admet-210	99	43	.	.	PUNCT
admet-210	100	1	[	[	X
admet-210	100	2	8	8	NUM
admet-210	100	3	]	]	PUNCT
admet-210	100	4	m.	m.	NOUN
admet-210	100	5	garland	garland	PROPN
admet-210	100	6	,	,	PUNCT
admet-210	100	7	k.m	k.m	PROPN
admet-210	100	8	.	.	PROPN
admet-210	100	9	abildskov	abildskov	PROPN
admet-210	100	10	,	,	PUNCT
admet-210	100	11	t.w	t.w	PROPN
admet-210	100	12	.	.	PROPN
admet-210	100	13	kiu	kiu	PROPN
admet-210	100	14	,	,	PUNCT
admet-210	100	15	s.s	s.s	PROPN
admet-210	100	16	.	.	PROPN
admet-210	100	17	daniel	daniel	PROPN
admet-210	100	18	,	,	PUNCT
admet-210	100	19	r.i	r.i	PROPN
admet-210	100	20	.	.	PROPN
admet-210	100	21	stark	stark	PROPN
admet-210	100	22	,	,	PUNCT
admet-210	100	23	drug	drug	NOUN
admet-210	100	24	metabolism	metabolism	NOUN
admet-210	100	25	and	and	CCONJ
admet-210	100	26	disposition	disposition	NOUN
admet-210	100	27	:	:	PUNCT
admet-210	100	28	the	the	DET
admet-210	100	29	biological	biological	ADJ
admet-210	100	30	fate	fate	NOUN
admet-210	100	31	of	of	ADP
admet-210	100	32	chemicals	chemical	NOUN
admet-210	100	33	33	33	NUM
admet-210	100	34	(	(	PUNCT
admet-210	100	35	2005	2005	NUM
admet-210	100	36	)	)	PUNCT
admet-210	100	37	68	68	NUM
admet-210	100	38	-	-	SYM
admet-210	100	39	76	76	NUM
admet-210	100	40	.	.	PUNCT
admet-210	101	1	[	[	X
admet-210	101	2	9	9	NUM
admet-210	101	3	]	]	X
admet-210	101	4	m.r	m.r	PROPN
admet-210	101	5	.	.	PROPN
admet-210	101	6	juchau	juchau	PROPN
admet-210	101	7	,	,	PUNCT
admet-210	101	8	nida	nida	PROPN
admet-210	101	9	research	research	PROPN
admet-210	101	10	monograph	monograph	PROPN
admet-210	101	11	60	60	NUM
admet-210	101	12	(	(	PUNCT
admet-210	101	13	1985	1985	NUM
admet-210	101	14	)	)	PUNCT
admet-210	101	15	17	17	NUM
admet-210	101	16	-	-	SYM
admet-210	101	17	24	24	NUM
admet-210	101	18	.	.	PUNCT
admet-210	102	1	[	[	X
admet-210	102	2	10	10	NUM
admet-210	102	3	]	]	X
admet-210	102	4	g.d	g.d	PROPN
admet-210	102	5	.	.	PROPN
admet-210	102	6	anderson	anderson	PROPN
admet-210	102	7	,	,	PUNCT
admet-210	102	8	clinical	clinical	ADJ
admet-210	102	9	pharmacokinetics	pharmacokinetic	NOUN
admet-210	102	10	44	44	NUM
admet-210	102	11	(	(	PUNCT
admet-210	102	12	2005	2005	NUM
admet-210	102	13	)	)	PUNCT
admet-210	102	14	989	989	NUM
admet-210	102	15	-	-	SYM
admet-210	102	16	1008	1008	NUM
admet-210	102	17	.	.	PUNCT
admet-210	103	1	[	[	X
admet-210	103	2	11	11	NUM
admet-210	103	3	]	]	PUNCT
admet-210	103	4	h.	h.	PROPN
admet-210	103	5	malm	malm	PROPN
admet-210	103	6	,	,	PUNCT
admet-210	103	7	j.	j.	PROPN
admet-210	103	8	martikainen	martikainen	PROPN
admet-210	103	9	,	,	PUNCT
admet-210	103	10	t.	t.	NOUN
admet-210	103	11	klaukka	klaukka	PROPN
admet-210	103	12	,	,	PUNCT
admet-210	103	13	p.j	p.j	PROPN
admet-210	103	14	.	.	PROPN
admet-210	103	15	neuvonen	neuvonen	PROPN
admet-210	103	16	,	,	PUNCT
admet-210	103	17	drug	drug	NOUN
admet-210	103	18	safety	safety	NOUN
admet-210	103	19	27	27	NUM
admet-210	103	20	(	(	PUNCT
admet-210	103	21	2004	2004	NUM
admet-210	103	22	)	)	PUNCT
admet-210	103	23	899	899	NUM
admet-210	103	24	-	-	SYM
admet-210	103	25	908	908	NUM
admet-210	103	26	.	.	PUNCT
admet-210	104	1	[	[	X
admet-210	104	2	12	12	NUM
admet-210	104	3	]	]	PUNCT
admet-210	104	4	r.	r.	PROPN
admet-210	104	5	sannerstedt	sannerstedt	PROPN
admet-210	104	6	,	,	PUNCT
admet-210	104	7	p.	p.	PROPN
admet-210	104	8	lundborg	lundborg	PROPN
admet-210	104	9	,	,	PUNCT
admet-210	104	10	b.r	b.r	PROPN
admet-210	104	11	.	.	PROPN
admet-210	104	12	danielsson	danielsson	PROPN
admet-210	104	13	,	,	PUNCT
admet-210	104	14	i.	i.	PROPN
admet-210	104	15	kihlstrom	kihlstrom	PROPN
admet-210	104	16	,	,	PUNCT
admet-210	104	17	g.	g.	PROPN
admet-210	104	18	alvan	alvan	PROPN
admet-210	104	19	,	,	PUNCT
admet-210	104	20	b.	b.	PROPN
admet-210	104	21	prame	prame	PROPN
admet-210	104	22	,	,	PUNCT
admet-210	104	23	e.	e.	PROPN
admet-210	104	24	ridley	ridley	PROPN
admet-210	104	25	,	,	PUNCT
admet-210	104	26	drug	drug	NOUN
admet-210	104	27	safety	safety	NOUN
admet-210	104	28	14	14	NUM
admet-210	104	29	(	(	PUNCT
admet-210	104	30	1996	1996	NUM
admet-210	104	31	)	)	PUNCT
admet-210	104	32	69	69	NUM
admet-210	104	33	-	-	SYM
admet-210	104	34	77	77	NUM
admet-210	104	35	.	.	PUNCT
admet-210	105	1	[	[	X
admet-210	105	2	13	13	NUM
admet-210	105	3	]	]	X
admet-210	105	4	g.g	g.g	PROPN
admet-210	105	5	.	.	PROPN
admet-210	105	6	briggs	briggs	PROPN
admet-210	105	7	,	,	PUNCT
admet-210	105	8	r.k	r.k	PROPN
admet-210	105	9	.	.	PROPN
admet-210	105	10	freeman	freeman	PROPN
admet-210	105	11	,	,	PUNCT
admet-210	105	12	s.j	s.j	PROPN
admet-210	105	13	.	.	PROPN
admet-210	105	14	yaffe	yaffe	PROPN
admet-210	105	15	,	,	PUNCT
admet-210	105	16	drugs	drug	NOUN
admet-210	105	17	in	in	ADP
admet-210	105	18	pregnancy	pregnancy	NOUN
admet-210	105	19	and	and	CCONJ
admet-210	105	20	lactation	lactation	NOUN
admet-210	105	21	:	:	PUNCT
admet-210	105	22	a	a	DET
admet-210	105	23	reference	reference	NOUN
admet-210	105	24	guide	guide	NOUN
admet-210	105	25	to	to	PART
admet-210	105	26	fetal	fetal	ADJ
admet-210	105	27	and	and	CCONJ
admet-210	105	28	neonatal	neonatal	ADJ
admet-210	105	29	risk	risk	NOUN
admet-210	105	30	,	,	PUNCT
admet-210	105	31	lippincott	lippincott	PROPN
admet-210	105	32	williams	williams	PROPN
admet-210	105	33	&	&	CCONJ
admet-210	105	34	wilkins2012	wilkins2012	PROPN
admet-210	105	35	.	.	PUNCT
admet-210	106	1	[	[	X
admet-210	106	2	14	14	NUM
admet-210	106	3	]	]	X
admet-210	106	4	p.	p.	NOUN
admet-210	106	5	baranczewski	baranczewski	PROPN
admet-210	106	6	,	,	PUNCT
admet-210	106	7	a.	a.	NOUN
admet-210	106	8	stanczak	stanczak	PROPN
admet-210	106	9	,	,	PUNCT
admet-210	106	10	k.	k.	PROPN
admet-210	106	11	sundberg	sundberg	PROPN
admet-210	106	12	,	,	PUNCT
admet-210	106	13	r.	r.	PROPN
admet-210	106	14	svensson	svensson	PROPN
admet-210	106	15	,	,	PUNCT
admet-210	106	16	a.	a.	PROPN
admet-210	106	17	wallin	wallin	PROPN
admet-210	106	18	,	,	PUNCT
admet-210	106	19	j.	j.	PROPN
admet-210	106	20	jansson	jansson	PROPN
admet-210	106	21	,	,	PUNCT
admet-210	106	22	p.	p.	NOUN
admet-210	106	23	garberg	garberg	PROPN
admet-210	106	24	,	,	PUNCT
admet-210	106	25	h.	h.	PROPN
admet-210	106	26	postlind	postlind	PROPN
admet-210	106	27	,	,	PUNCT
admet-210	106	28	pharmacological	pharmacological	ADJ
admet-210	106	29	reports	report	NOUN
admet-210	106	30	:	:	PUNCT
admet-210	106	31	pr	pr	NOUN
admet-210	106	32	58	58	NUM
admet-210	106	33	(	(	PUNCT
admet-210	106	34	2006	2006	NUM
admet-210	106	35	)	)	PUNCT
admet-210	106	36	453	453	NUM
admet-210	106	37	-	-	SYM
admet-210	106	38	472	472	NUM
admet-210	106	39	.	.	PUNCT
admet-210	107	1	[	[	X
admet-210	107	2	15	15	NUM
admet-210	107	3	]	]	X
admet-210	107	4	r.	r.	PROPN
admet-210	107	5	gebhardt	gebhardt	PROPN
admet-210	107	6	,	,	PUNCT
admet-210	107	7	j.g	j.g	PROPN
admet-210	107	8	.	.	PROPN
admet-210	107	9	hengstler	hengstler	PROPN
admet-210	107	10	,	,	PUNCT
admet-210	107	11	d.	d.	PROPN
admet-210	107	12	muller	muller	PROPN
admet-210	107	13	,	,	PUNCT
admet-210	107	14	r.	r.	PROPN
admet-210	107	15	glockner	glockner	PROPN
admet-210	107	16	,	,	PUNCT
admet-210	107	17	p.	p.	PROPN
admet-210	107	18	buenning	buenning	PROPN
admet-210	107	19	,	,	PUNCT
admet-210	107	20	b.	b.	PROPN
admet-210	107	21	laube	laube	PROPN
admet-210	107	22	,	,	PUNCT
admet-210	107	23	e.	e.	PROPN
admet-210	107	24	schmelzer	schmelzer	PROPN
admet-210	107	25	,	,	PUNCT
admet-210	107	26	m.	m.	NOUN
admet-210	107	27	ullrich	ullrich	PROPN
admet-210	107	28	,	,	PUNCT
admet-210	107	29	d.	d.	PROPN
admet-210	107	30	utesch	utesch	PROPN
admet-210	107	31	,	,	PUNCT
admet-210	107	32	n.	n.	PROPN
admet-210	107	33	hewitt	hewitt	PROPN
admet-210	107	34	,	,	PUNCT
admet-210	107	35	m.	m.	NOUN
admet-210	107	36	ringel	ringel	NOUN
admet-210	107	37	,	,	PUNCT
admet-210	107	38	b.r	b.r	PROPN
admet-210	107	39	.	.	PROPN
admet-210	107	40	hilz	hilz	NOUN
admet-210	107	41	,	,	PUNCT
admet-210	107	42	a.	a.	NOUN
admet-210	107	43	bader	bader	PROPN
admet-210	107	44	,	,	PUNCT
admet-210	107	45	a.	a.	NOUN
admet-210	107	46	langsch	langsch	PROPN
admet-210	107	47	,	,	PUNCT
admet-210	107	48	t.	t.	PROPN
admet-210	107	49	koose	koose	PROPN
admet-210	107	50	,	,	PUNCT
admet-210	107	51	h.j	h.j	PROPN
admet-210	107	52	.	.	PROPN
admet-210	107	53	burger	burger	NOUN
admet-210	107	54	,	,	PUNCT
admet-210	107	55	j.	j.	PROPN
admet-210	107	56	maas	maas	PROPN
admet-210	107	57	,	,	PUNCT
admet-210	107	58	f.	f.	PROPN
admet-210	107	59	oesch	oesch	PROPN
admet-210	107	60	,	,	PUNCT
admet-210	107	61	drug	drug	NOUN
admet-210	107	62	metabolism	metabolism	NOUN
admet-210	107	63	reviews	review	NOUN
admet-210	107	64	35	35	NUM
admet-210	107	65	(	(	PUNCT
admet-210	107	66	2003	2003	NUM
admet-210	107	67	)	)	PUNCT
admet-210	107	68	145	145	NUM
admet-210	107	69	-	-	SYM
admet-210	107	70	213	213	NUM
admet-210	107	71	.	.	PUNCT
admet-210	108	1	[	[	X
admet-210	108	2	16	16	NUM
admet-210	108	3	]	]	X
admet-210	108	4	r.	r.	PROPN
admet-210	108	5	yuan	yuan	PROPN
admet-210	108	6	,	,	PUNCT
admet-210	108	7	s.	s.	PROPN
admet-210	108	8	madani	madani	PROPN
admet-210	108	9	,	,	PUNCT
admet-210	108	10	x.x	x.x	PROPN
admet-210	108	11	.	.	PUNCT
admet-210	108	12	wei	wei	PROPN
admet-210	108	13	,	,	PUNCT
admet-210	108	14	k.	k.	PROPN
admet-210	108	15	reynolds	reynolds	PROPN
admet-210	108	16	,	,	PUNCT
admet-210	108	17	s.m	s.m	PROPN
admet-210	108	18	.	.	PROPN
admet-210	108	19	huang	huang	PROPN
admet-210	108	20	,	,	PUNCT
admet-210	108	21	drug	drug	NOUN
admet-210	108	22	metabolism	metabolism	NOUN
admet-210	108	23	and	and	CCONJ
admet-210	108	24	disposition	disposition	NOUN
admet-210	108	25	:	:	PUNCT
admet-210	108	26	the	the	DET
admet-210	108	27	biological	biological	ADJ
admet-210	108	28	fate	fate	NOUN
admet-210	108	29	of	of	ADP
admet-210	108	30	chemicals	chemical	NOUN
admet-210	108	31	30	30	NUM
admet-210	108	32	(	(	PUNCT
admet-210	108	33	2002	2002	NUM
admet-210	108	34	)	)	PUNCT
admet-210	108	35	1311	1311	NUM
admet-210	108	36	-	-	SYM
admet-210	108	37	1319	1319	NUM
admet-210	108	38	.	.	PUNCT
admet-210	109	1	[	[	X
admet-210	109	2	17	17	NUM
admet-210	109	3	]	]	X
admet-210	109	4	c.m	c.m	PROPN
admet-210	109	5	.	.	PROPN
admet-210	110	1	habibullah	habibullah	PROPN
admet-210	110	2	,	,	PUNCT
admet-210	110	3	i.h	i.h	PROPN
admet-210	110	4	.	.	PROPN
admet-210	110	5	syed	syed	PROPN
admet-210	110	6	,	,	PUNCT
admet-210	110	7	a.	a.	PROPN
admet-210	110	8	qamar	qamar	PROPN
admet-210	110	9	,	,	PUNCT
admet-210	110	10	z.	z.	PROPN
admet-210	110	11	taher	taher	PROPN
admet-210	110	12	-	-	PUNCT
admet-210	110	13	uz	uz	PROPN
admet-210	110	14	,	,	PUNCT
admet-210	110	15	transplantation	transplantation	VERB
admet-210	110	16	58	58	NUM
admet-210	110	17	(	(	PUNCT
admet-210	110	18	1994	1994	NUM
admet-210	110	19	)	)	PUNCT
admet-210	110	20	951	951	NUM
admet-210	110	21	-	-	SYM
admet-210	110	22	952	952	NUM
admet-210	110	23	.	.	PUNCT
admet-210	111	1	[	[	X
admet-210	111	2	18	18	NUM
admet-210	111	3	]	]	X
admet-210	111	4	m.n	m.n	PROPN
admet-210	111	5	.	.	PROPN
admet-210	111	6	rao	rao	PROPN
admet-210	111	7	,	,	PUNCT
admet-210	111	8	b.	b.	PROPN
admet-210	111	9	biju	biju	PROPN
admet-210	111	10	,	,	PUNCT
admet-210	111	11	a.k	a.k	PROPN
admet-210	111	12	.	.	PROPN
admet-210	111	13	ansar	ansar	PROPN
admet-210	111	14	,	,	PUNCT
admet-210	111	15	s.	s.	PROPN
admet-210	111	16	mujeeb	mujeeb	PROPN
admet-210	111	17	,	,	PUNCT
admet-210	111	18	m.	m.	PROPN
admet-210	111	19	ramesh	ramesh	PROPN
admet-210	111	20	,	,	PUNCT
admet-210	111	21	n.r	n.r	PROPN
admet-210	111	22	.	.	PROPN
admet-210	111	23	srinivas	srinivas	PROPN
admet-210	111	24	,	,	PUNCT
admet-210	111	25	xenobiotica	xenobiotica	PROPN
admet-210	111	26	;	;	PUNCT
admet-210	111	27	the	the	DET
admet-210	111	28	fate	fate	NOUN
admet-210	111	29	of	of	ADP
admet-210	111	30	foreign	foreign	ADJ
admet-210	111	31	compounds	compound	NOUN
admet-210	111	32	in	in	ADP
admet-210	111	33	biological	biological	ADJ
admet-210	111	34	systems	system	NOUN
admet-210	111	35	33	33	NUM
admet-210	111	36	(	(	PUNCT
admet-210	111	37	2003	2003	NUM
admet-210	111	38	)	)	PUNCT
admet-210	111	39	1233	1233	NUM
admet-210	111	40	-	-	SYM
admet-210	111	41	1245	1245	NUM
admet-210	111	42	.	.	PUNCT
admet-210	112	1	[	[	X
admet-210	112	2	19	19	NUM
admet-210	112	3	]	]	X
admet-210	112	4	h.m	h.m	PROPN
admet-210	112	5	.	.	PROPN
admet-210	112	6	jones	jones	PROPN
admet-210	112	7	,	,	PUNCT
admet-210	112	8	j.b	j.b	PROPN
admet-210	112	9	.	.	PROPN
admet-210	112	10	houston	houston	PROPN
admet-210	112	11	,	,	PUNCT
admet-210	112	12	drug	drug	NOUN
admet-210	112	13	metabolism	metabolism	NOUN
admet-210	112	14	and	and	CCONJ
admet-210	112	15	disposition	disposition	NOUN
admet-210	112	16	:	:	PUNCT
admet-210	112	17	the	the	DET
admet-210	112	18	biological	biological	ADJ
admet-210	112	19	fate	fate	NOUN
admet-210	112	20	of	of	ADP
admet-210	112	21	chemicals	chemical	NOUN
admet-210	112	22	32	32	NUM
admet-210	112	23	(	(	PUNCT
admet-210	112	24	2004	2004	NUM
admet-210	112	25	)	)	PUNCT
admet-210	112	26	973	973	NUM
admet-210	112	27	-	-	SYM
admet-210	112	28	982	982	NUM
admet-210	112	29	.	.	PUNCT
admet-210	113	1	[	[	X
admet-210	113	2	20	20	NUM
admet-210	113	3	]	]	X
admet-210	113	4	a.p	a.p	PROPN
admet-210	113	5	.	.	PROPN
admet-210	113	6	li	li	PROPN
admet-210	113	7	,	,	PUNCT
admet-210	113	8	drug	drug	NOUN
admet-210	113	9	discovery	discovery	NOUN
admet-210	113	10	today	today	NOUN
admet-210	113	11	6	6	NUM
admet-210	113	12	(	(	PUNCT
admet-210	113	13	2001	2001	NUM
admet-210	113	14	)	)	PUNCT
admet-210	113	15	357	357	NUM
admet-210	113	16	-	-	SYM
admet-210	113	17	366	366	NUM
admet-210	113	18	.	.	PUNCT
admet-210	114	1	[	[	X
admet-210	114	2	21	21	NUM
admet-210	114	3	]	]	PUNCT
admet-210	114	4	k.	k.	PROPN
admet-210	114	5	hoshino	hoshino	PROPN
admet-210	114	6	,	,	PUNCT
admet-210	114	7	h.	h.	PROPN
admet-210	114	8	inouye	inouye	PROPN
admet-210	114	9	,	,	PUNCT
admet-210	114	10	t.	t.	PROPN
admet-210	114	11	unokuchi	unokuchi	PROPN
admet-210	114	12	,	,	PUNCT
admet-210	114	13	m.	m.	PROPN
admet-210	114	14	ito	ito	PROPN
admet-210	114	15	,	,	PUNCT
admet-210	114	16	n.	n.	PROPN
admet-210	114	17	tamaoki	tamaoki	PROPN
admet-210	114	18	,	,	PUNCT
admet-210	114	19	k.	k.	PROPN
admet-210	114	20	tsuji	tsuji	PROPN
admet-210	114	21	,	,	PUNCT
admet-210	114	22	diabete	diabete	PROPN
admet-210	114	23	&	&	CCONJ
admet-210	114	24	metabolisme	metabolisme	PROPN
admet-210	114	25	2	2	NUM
admet-210	114	26	(	(	PUNCT
admet-210	114	27	1976	1976	NUM
admet-210	114	28	)	)	PUNCT
admet-210	114	29	157	157	NUM
admet-210	114	30	-	-	SYM
admet-210	114	31	158	158	NUM
admet-210	114	32	.	.	PUNCT
admet-210	115	1	[	[	X
admet-210	115	2	22	22	NUM
admet-210	115	3	]	]	X
admet-210	115	4	u.	u.	PROPN
admet-210	115	5	yasar	yasar	PROPN
admet-210	115	6	,	,	PUNCT
admet-210	115	7	e.	e.	PROPN
admet-210	115	8	eliasson	eliasson	PROPN
admet-210	115	9	,	,	PUNCT
admet-210	115	10	c.	c.	PROPN
admet-210	115	11	forslund	forslund	NOUN
admet-210	115	12	-	-	PUNCT
admet-210	115	13	bergengren	bergengren	NOUN
admet-210	115	14	,	,	PUNCT
admet-210	115	15	g.	g.	PROPN
admet-210	115	16	tybring	tybring	NOUN
admet-210	115	17	,	,	PUNCT
admet-210	115	18	m.	m.	NOUN
admet-210	115	19	gadd	gadd	PROPN
admet-210	115	20	,	,	PUNCT
admet-210	115	21	f.	f.	PROPN
admet-210	115	22	sjoqvist	sjoqvist	PROPN
admet-210	115	23	,	,	PUNCT
admet-210	115	24	m.l	m.l	PROPN
admet-210	115	25	.	.	PROPN
admet-210	115	26	dahl	dahl	PROPN
admet-210	115	27	,	,	PUNCT
admet-210	115	28	european	european	ADJ
admet-210	115	29	journal	journal	PROPN
admet-210	115	30	of	of	ADP
admet-210	115	31	clinical	clinical	ADJ
admet-210	115	32	pharmacology	pharmacology	NOUN
admet-210	115	33	57	57	NUM
admet-210	115	34	(	(	PUNCT
admet-210	115	35	2001	2001	NUM
admet-210	115	36	)	)	PUNCT
admet-210	115	37	729	729	NUM
admet-210	115	38	-	-	SYM
admet-210	115	39	735	735	NUM
admet-210	115	40	.	.	PUNCT
admet-210	115	41	shaik	shaik	PROPN
admet-210	115	42	et	et	PROPN
admet-210	115	43	al	al	PROPN
admet-210	115	44	.	.	PROPN
admet-210	115	45	admet	admet	PROPN
admet-210	115	46	&	&	CCONJ
admet-210	115	47	dmpk	dmpk	PROPN
admet-210	115	48	4(2	4(2	NUM
admet-210	115	49	)	)	PUNCT
admet-210	115	50	(	(	PUNCT
admet-210	115	51	2016	2016	NUM
admet-210	115	52	)	)	PUNCT
admet-210	115	53	84	84	NUM
admet-210	115	54	-	-	SYM
admet-210	115	55	90	90	NUM
admet-210	115	56	90	90	NUM
admet-210	115	57	[	[	SYM
admet-210	115	58	23	23	NUM
admet-210	115	59	]	]	X
admet-210	115	60	s.m	s.m	PROPN
admet-210	115	61	.	.	PROPN
admet-210	115	62	de	de	PROPN
admet-210	115	63	morais	morais	PROPN
admet-210	115	64	,	,	PUNCT
admet-210	115	65	g.r	g.r	PROPN
admet-210	115	66	.	.	PROPN
admet-210	115	67	wilkinson	wilkinson	PROPN
admet-210	115	68	,	,	PUNCT
admet-210	115	69	j.	j.	PROPN
admet-210	115	70	blaisdell	blaisdell	PROPN
admet-210	115	71	,	,	PUNCT
admet-210	115	72	k.	k.	PROPN
admet-210	115	73	nakamura	nakamura	PROPN
admet-210	115	74	,	,	PUNCT
admet-210	115	75	u.a	u.a	PROPN
admet-210	115	76	.	.	PROPN
admet-210	115	77	meyer	meyer	PROPN
admet-210	115	78	,	,	PUNCT
admet-210	115	79	j.a	j.a	PROPN
admet-210	115	80	.	.	PROPN
admet-210	115	81	goldstein	goldstein	PROPN
admet-210	115	82	,	,	PUNCT
admet-210	115	83	the	the	DET
admet-210	115	84	journal	journal	NOUN
admet-210	115	85	of	of	ADP
admet-210	115	86	biological	biological	ADJ
admet-210	115	87	chemistry	chemistry	NOUN
admet-210	115	88	269	269	NUM
admet-210	115	89	(	(	PUNCT
admet-210	115	90	1994	1994	NUM
admet-210	115	91	)	)	PUNCT
admet-210	115	92	15419	15419	NUM
admet-210	115	93	-	-	SYM
admet-210	115	94	15422	15422	NUM
admet-210	115	95	.	.	PUNCT
admet-210	116	1	[	[	X
admet-210	116	2	24	24	NUM
admet-210	116	3	]	]	X
admet-210	116	4	n.l	n.l	PROPN
admet-210	116	5	.	.	PROPN
admet-210	116	6	kerry	kerry	PROPN
admet-210	116	7	,	,	PUNCT
admet-210	116	8	a.a	a.a	PROPN
admet-210	116	9	.	.	PROPN
admet-210	116	10	somogyi	somogyi	PROPN
admet-210	116	11	,	,	PUNCT
admet-210	116	12	f.	f.	PROPN
admet-210	116	13	bochner	bochner	PROPN
admet-210	116	14	,	,	PUNCT
admet-210	116	15	g.	g.	PROPN
admet-210	116	16	mikus	mikus	PROPN
admet-210	116	17	,	,	PUNCT
admet-210	116	18	british	british	ADJ
admet-210	116	19	journal	journal	PROPN
admet-210	116	20	of	of	ADP
admet-210	116	21	clinical	clinical	ADJ
admet-210	116	22	pharmacology	pharmacology	NOUN
admet-210	116	23	38	38	NUM
admet-210	116	24	(	(	PUNCT
admet-210	116	25	1994	1994	NUM
admet-210	116	26	)	)	PUNCT
admet-210	116	27	243	243	NUM
admet-210	116	28	-	-	SYM
admet-210	116	29	248	248	NUM
admet-210	116	30	.	.	PUNCT
admet-210	117	1	[	[	X
admet-210	117	2	25	25	NUM
admet-210	117	3	]	]	X
admet-210	117	4	k.c	k.c	PROPN
admet-210	117	5	.	.	PROPN
admet-210	117	6	patki	patki	PROPN
admet-210	117	7	,	,	PUNCT
admet-210	117	8	l.l	l.l	PROPN
admet-210	117	9	.	.	PROPN
admet-210	117	10	von	von	PROPN
admet-210	117	11	moltke	moltke	PROPN
admet-210	117	12	,	,	PUNCT
admet-210	117	13	d.j	d.j	PROPN
admet-210	117	14	.	.	PROPN
admet-210	117	15	greenblatt	greenblatt	PROPN
admet-210	117	16	,	,	PUNCT
admet-210	117	17	drug	drug	NOUN
admet-210	117	18	metabolism	metabolism	NOUN
admet-210	117	19	and	and	CCONJ
admet-210	117	20	disposition	disposition	NOUN
admet-210	117	21	:	:	PUNCT
admet-210	117	22	the	the	DET
admet-210	117	23	biological	biological	ADJ
admet-210	117	24	fate	fate	NOUN
admet-210	117	25	of	of	ADP
admet-210	117	26	chemicals	chemical	NOUN
admet-210	117	27	31	31	NUM
admet-210	117	28	(	(	PUNCT
admet-210	117	29	2003	2003	NUM
admet-210	117	30	)	)	PUNCT
admet-210	117	31	938	938	NUM
admet-210	117	32	-	-	SYM
admet-210	117	33	944	944	NUM
admet-210	117	34	.	.	PUNCT
admet-210	118	1	[	[	X
admet-210	118	2	26	26	NUM
admet-210	118	3	]	]	X
admet-210	118	4	u.	u.	NOUN
admet-210	118	5	food	food	PROPN
admet-210	118	6	and	and	CCONJ
admet-210	118	7	drug	drug	NOUN
admet-210	118	8	administration	administration	NOUN
admet-210	118	9	,	,	PUNCT
admet-210	118	10	guidance	guidance	NOUN
admet-210	118	11	for	for	ADP
admet-210	118	12	industry	industry	NOUN
admet-210	118	13	drug	drug	NOUN
admet-210	118	14	interaction	interaction	NOUN
admet-210	118	15	studies	study	NOUN
admet-210	118	16	study	study	VERB
admet-210	118	17	design	design	NOUN
admet-210	118	18	,	,	PUNCT
admet-210	118	19	data	datum	NOUN
admet-210	118	20	analysis	analysis	NOUN
admet-210	118	21	,	,	PUNCT
admet-210	118	22	and	and	CCONJ
admet-210	118	23	implications	implication	NOUN
admet-210	118	24	for	for	ADP
admet-210	118	25	dosing	dose	VERB
admet-210	118	26	and	and	CCONJ
admet-210	118	27	labeling	labeling	NOUN
admet-210	118	28	http://www.fda.gov/ohrms/dockets/98fr/06d-0344-gdl0001.pdf	http://www.fda.gov/ohrms/dockets/98fr/06d-0344-gdl0001.pdf	PROPN
admet-210	118	29	,	,	PUNCT
admet-210	118	30	2006	2006	NUM
admet-210	118	31	.	.	PUNCT
admet-210	119	1	[	[	X
admet-210	119	2	27	27	NUM
admet-210	119	3	]	]	X
admet-210	119	4	r.s	r.s	PROPN
admet-210	119	5	.	.	PROPN
admet-210	119	6	obach	obach	PROPN
admet-210	119	7	,	,	PUNCT
admet-210	119	8	a.e	a.e	PROPN
admet-210	119	9	.	.	PROPN
admet-210	119	10	reed	reed	PROPN
admet-210	119	11	-	-	PUNCT
admet-210	119	12	hagen	hagen	PROPN
admet-210	119	13	,	,	PUNCT
admet-210	119	14	drug	drug	NOUN
admet-210	119	15	metabolism	metabolism	NOUN
admet-210	119	16	and	and	CCONJ
admet-210	119	17	disposition	disposition	NOUN
admet-210	119	18	:	:	PUNCT
admet-210	119	19	the	the	DET
admet-210	119	20	biological	biological	ADJ
admet-210	119	21	fate	fate	NOUN
admet-210	119	22	of	of	ADP
admet-210	119	23	chemicals	chemical	NOUN
admet-210	119	24	30	30	NUM
admet-210	119	25	(	(	PUNCT
admet-210	119	26	2002	2002	NUM
admet-210	119	27	)	)	PUNCT
admet-210	119	28	831	831	NUM
admet-210	119	29	-	-	SYM
admet-210	119	30	837	837	NUM
admet-210	119	31	.	.	PUNCT
admet-210	120	1	[	[	X
admet-210	120	2	28	28	NUM
admet-210	120	3	]	]	X
admet-210	120	4	h.s	h.s	PROPN
admet-210	120	5	.	.	PROPN
admet-210	120	6	brown	brown	PROPN
admet-210	120	7	,	,	PUNCT
admet-210	120	8	m.	m.	NOUN
admet-210	120	9	griffin	griffin	PROPN
admet-210	120	10	,	,	PUNCT
admet-210	120	11	j.b	j.b	PROPN
admet-210	120	12	.	.	PROPN
admet-210	120	13	houston	houston	PROPN
admet-210	120	14	,	,	PUNCT
admet-210	120	15	drug	drug	NOUN
admet-210	120	16	metabolism	metabolism	NOUN
admet-210	120	17	and	and	CCONJ
admet-210	120	18	disposition	disposition	NOUN
admet-210	120	19	:	:	PUNCT
admet-210	120	20	the	the	DET
admet-210	120	21	biological	biological	ADJ
admet-210	120	22	fate	fate	NOUN
admet-210	120	23	of	of	ADP
admet-210	120	24	chemicals	chemical	NOUN
admet-210	120	25	35	35	NUM
admet-210	120	26	(	(	PUNCT
admet-210	120	27	2007	2007	NUM
admet-210	120	28	)	)	PUNCT
admet-210	120	29	293	293	NUM
admet-210	120	30	-	-	SYM
admet-210	120	31	301	301	NUM
admet-210	120	32	.	.	PUNCT
admet-210	121	1	[	[	X
admet-210	121	2	29	29	NUM
admet-210	121	3	]	]	X
admet-210	121	4	m.a	m.a	PROPN
admet-210	121	5	.	.	PROPN
admet-210	121	6	mohutsky	mohutsky	PROPN
admet-210	121	7	,	,	PUNCT
admet-210	121	8	j.y	j.y	PROPN
admet-210	121	9	.	.	PROPN
admet-210	121	10	chien	chien	PROPN
admet-210	121	11	,	,	PUNCT
admet-210	121	12	b.j	b.j	PROPN
admet-210	121	13	.	.	PROPN
admet-210	121	14	ring	ring	PROPN
admet-210	121	15	,	,	PUNCT
admet-210	121	16	s.a	s.a	PROPN
admet-210	121	17	.	.	PROPN
admet-210	121	18	wrighton	wrighton	PROPN
admet-210	121	19	,	,	PUNCT
admet-210	121	20	pharmaceutical	pharmaceutical	ADJ
admet-210	121	21	research	research	NOUN
admet-210	121	22	23	23	NUM
admet-210	121	23	(	(	PUNCT
admet-210	121	24	2006	2006	NUM
admet-210	121	25	)	)	PUNCT
admet-210	121	26	654	654	NUM
admet-210	121	27	-	-	SYM
admet-210	121	28	662	662	NUM
admet-210	121	29	.	.	PUNCT
admet-210	122	1	[	[	X
admet-210	122	2	30	30	NUM
admet-210	122	3	]	]	X
admet-210	122	4	r.s	r.s	PROPN
admet-210	122	5	.	.	PROPN
admet-210	122	6	obach	obach	PROPN
admet-210	122	7	,	,	PUNCT
admet-210	122	8	drug	drug	NOUN
admet-210	122	9	metabolism	metabolism	NOUN
admet-210	122	10	and	and	CCONJ
admet-210	122	11	disposition	disposition	NOUN
admet-210	122	12	:	:	PUNCT
admet-210	122	13	the	the	DET
admet-210	122	14	biological	biological	ADJ
admet-210	122	15	fate	fate	NOUN
admet-210	122	16	of	of	ADP
admet-210	122	17	chemicals	chemical	NOUN
admet-210	122	18	27	27	NUM
admet-210	122	19	(	(	PUNCT
admet-210	122	20	1999	1999	NUM
admet-210	122	21	)	)	PUNCT
admet-210	122	22	1350	1350	NUM
admet-210	122	23	-	-	SYM
admet-210	122	24	1359	1359	NUM
admet-210	122	25	.	.	PUNCT
admet-210	123	1	[	[	X
admet-210	123	2	31	31	NUM
admet-210	123	3	]	]	X
admet-210	123	4	y.	y.	NOUN
admet-210	123	5	naritomi	naritomi	PROPN
admet-210	123	6	,	,	PUNCT
admet-210	123	7	s.	s.	PROPN
admet-210	123	8	terashita	terashita	PROPN
admet-210	123	9	,	,	PUNCT
admet-210	123	10	a.	a.	NOUN
admet-210	123	11	kagayama	kagayama	PROPN
admet-210	123	12	,	,	PUNCT
admet-210	123	13	y.	y.	PROPN
admet-210	123	14	sugiyama	sugiyama	PROPN
admet-210	123	15	,	,	PUNCT
admet-210	123	16	drug	drug	NOUN
admet-210	123	17	metabolism	metabolism	NOUN
admet-210	123	18	and	and	CCONJ
admet-210	123	19	disposition	disposition	NOUN
admet-210	123	20	:	:	PUNCT
admet-210	123	21	the	the	DET
admet-210	123	22	biological	biological	ADJ
admet-210	123	23	fate	fate	NOUN
admet-210	123	24	of	of	ADP
admet-210	123	25	chemicals	chemical	NOUN
admet-210	123	26	31	31	NUM
admet-210	123	27	(	(	PUNCT
admet-210	123	28	2003	2003	NUM
admet-210	123	29	)	)	PUNCT
admet-210	123	30	580	580	NUM
admet-210	123	31	-	-	SYM
admet-210	123	32	588	588	NUM
admet-210	123	33	.	.	PUNCT
admet-210	124	1	[	[	X
admet-210	124	2	32	32	NUM
admet-210	124	3	]	]	SYM
admet-210	124	4	k.p	k.p	PROPN
admet-210	124	5	.	.	PROPN
admet-210	124	6	kanebratt	kanebratt	PROPN
admet-210	124	7	,	,	PUNCT
admet-210	124	8	t.b	t.b	PROPN
admet-210	124	9	.	.	PROPN
admet-210	124	10	andersson	andersson	PROPN
admet-210	124	11	,	,	PUNCT
admet-210	124	12	drug	drug	NOUN
admet-210	124	13	metabolism	metabolism	NOUN
admet-210	124	14	and	and	CCONJ
admet-210	124	15	disposition	disposition	NOUN
admet-210	124	16	:	:	PUNCT
admet-210	124	17	the	the	DET
admet-210	124	18	biological	biological	ADJ
admet-210	124	19	fate	fate	NOUN
admet-210	124	20	of	of	ADP
admet-210	124	21	chemicals	chemical	NOUN
admet-210	124	22	36	36	NUM
admet-210	124	23	(	(	PUNCT
admet-210	124	24	2008	2008	NUM
admet-210	124	25	)	)	PUNCT
admet-210	124	26	1444	1444	NUM
admet-210	124	27	-	-	SYM
admet-210	124	28	1452	1452	NUM
admet-210	124	29	.	.	PUNCT
admet-210	125	1	©	©	PROPN
admet-210	125	2	2016	2016	NUM
admet-210	125	3	by	by	ADP
admet-210	125	4	the	the	DET
admet-210	125	5	authors	author	NOUN
admet-210	125	6	;	;	PUNCT
admet-210	125	7	licensee	licensee	PROPN
admet-210	125	8	iapc	iapc	PROPN
admet-210	125	9	,	,	PUNCT
admet-210	125	10	zagreb	zagreb	PROPN
admet-210	125	11	,	,	PUNCT
admet-210	125	12	croatia	croatia	PROPN
admet-210	125	13	.	.	PUNCT
admet-210	126	1	this	this	DET
admet-210	126	2	article	article	NOUN
admet-210	126	3	is	be	AUX
admet-210	126	4	an	an	DET
admet-210	126	5	open	open	ADJ
admet-210	126	6	-	-	PUNCT
admet-210	126	7	access	access	NOUN
admet-210	126	8	article	article	NOUN
admet-210	126	9	distributed	distribute	VERB
admet-210	126	10	under	under	ADP
admet-210	126	11	the	the	DET
admet-210	126	12	terms	term	NOUN
admet-210	126	13	and	and	CCONJ
admet-210	126	14	conditions	condition	NOUN
admet-210	126	15	of	of	ADP
admet-210	126	16	the	the	DET
admet-210	126	17	creative	creative	ADJ
admet-210	126	18	commons	common	NOUN
admet-210	126	19	attribution	attribution	NOUN
admet-210	126	20	license	license	NOUN
admet-210	126	21	(	(	PUNCT
admet-210	126	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-210	126	23	)	)	PUNCT
admet-210	126	24	http://www.fda.gov/ohrms/dockets/98fr/06d-0344-gdl0001.pdf	http://www.fda.gov/ohrms/dockets/98fr/06d-0344-gdl0001.pdf	PROPN
admet-210	126	25	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN