id	sid	tid	token	lemma	pos
admet-217	1	1	manuscript	manuscript	PROPN
admet-217	1	2	doi	doi	PROPN
admet-217	1	3	:	:	PUNCT
admet-217	1	4	10.5599	10.5599	NUM
admet-217	1	5	/	/	SYM
admet-217	1	6	admet.3.3.217	admet.3.3.217	PROPN
admet-217	1	7	154	154	NUM
admet-217	1	8	admet	admet	PROPN
admet-217	1	9	&	&	CCONJ
admet-217	1	10	dmpk	dmpk	PROPN
admet-217	1	11	3(3	3(3	NUM
admet-217	1	12	)	)	PUNCT
admet-217	1	13	(	(	PUNCT
admet-217	1	14	2015	2015	NUM
admet-217	1	15	)	)	PUNCT
admet-217	1	16	154	154	NUM
admet-217	1	17	;	;	PUNCT
admet-217	1	18	doi	doi	NOUN
admet-217	1	19	:	:	PUNCT
admet-217	1	20	10.5599	10.5599	NUM
admet-217	1	21	/	/	SYM
admet-217	1	22	admet.3.3.217	admet.3.3.217	PROPN
admet-217	1	23	open	open	ADJ
admet-217	1	24	access	access	NOUN
admet-217	1	25	:	:	PUNCT
admet-217	1	26	issn	issn	PROPN
admet-217	1	27	:	:	PUNCT
admet-217	1	28	1848	1848	NUM
admet-217	1	29	-	-	SYM
admet-217	1	30	7718	7718	NUM
admet-217	1	31	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-217	1	32	editorial	editorial	NOUN
admet-217	1	33	research	research	NOUN
admet-217	1	34	in	in	ADP
admet-217	1	35	neurodegenerative	neurodegenerative	ADJ
admet-217	1	36	diseases	disease	NOUN
admet-217	1	37	:	:	PUNCT
admet-217	1	38	challenges	challenge	NOUN
admet-217	1	39	and	and	CCONJ
admet-217	1	40	solutions	solution	NOUN
admet-217	1	41	kin	kin	PROPN
admet-217	1	42	tam	tam	PROPN
admet-217	1	43	editor	editor	PROPN
admet-217	1	44	:	:	PUNCT
admet-217	1	45	admet	admet	PROPN
admet-217	1	46	&	&	CCONJ
admet-217	1	47	dmpk	dmpk	PROPN
admet-217	1	48	e	e	NOUN
admet-217	1	49	-	-	NOUN
admet-217	1	50	mail	mail	NOUN
admet-217	1	51	:	:	PUNCT
admet-217	1	52	kin_tam@iapchem.org	kin_tam@iapchem.org	ADJ
admet-217	1	53	the	the	DET
admet-217	1	54	need	need	NOUN
admet-217	1	55	of	of	ADP
admet-217	1	56	effective	effective	ADJ
admet-217	1	57	medicines	medicine	NOUN
admet-217	1	58	for	for	ADP
admet-217	1	59	the	the	DET
admet-217	1	60	treatment	treatment	NOUN
admet-217	1	61	of	of	ADP
admet-217	1	62	neurodegenerative	neurodegenerative	ADJ
admet-217	1	63	diseases	disease	NOUN
admet-217	1	64	,	,	PUNCT
admet-217	1	65	such	such	ADJ
admet-217	1	66	as	as	ADP
admet-217	1	67	alzheimer	alzheimer	PROPN
admet-217	1	68	’s	’s	PART
admet-217	1	69	disease	disease	NOUN
admet-217	1	70	and	and	CCONJ
admet-217	1	71	parkinson	parkinson	NOUN
admet-217	1	72	’s	’s	PART
admet-217	1	73	disease	disease	NOUN
admet-217	1	74	,	,	PUNCT
admet-217	1	75	is	be	AUX
admet-217	1	76	expected	expect	VERB
admet-217	1	77	to	to	PART
admet-217	1	78	increase	increase	VERB
admet-217	1	79	strongly	strongly	ADV
admet-217	1	80	in	in	ADP
admet-217	1	81	the	the	DET
admet-217	1	82	coming	come	VERB
admet-217	1	83	decades	decade	NOUN
admet-217	1	84	.	.	PUNCT
admet-217	2	1	though	though	SCONJ
admet-217	2	2	great	great	ADJ
admet-217	2	3	efforts	effort	NOUN
admet-217	2	4	have	have	AUX
admet-217	2	5	been	be	AUX
admet-217	2	6	paid	pay	VERB
admet-217	2	7	on	on	ADP
admet-217	2	8	research	research	NOUN
admet-217	2	9	,	,	PUNCT
admet-217	2	10	neurodegenerative	neurodegenerative	ADJ
admet-217	2	11	diseases	disease	NOUN
admet-217	2	12	remain	remain	VERB
admet-217	2	13	as	as	ADP
admet-217	2	14	urgent	urgent	ADJ
admet-217	2	15	unresolved	unresolved	ADJ
admet-217	2	16	problems	problem	NOUN
admet-217	2	17	in	in	ADP
admet-217	2	18	modern	modern	ADJ
admet-217	2	19	day	day	NOUN
admet-217	2	20	medicine	medicine	NOUN
admet-217	2	21	.	.	PUNCT
admet-217	3	1	at	at	ADP
admet-217	3	2	present	present	ADJ
admet-217	3	3	,	,	PUNCT
admet-217	3	4	there	there	PRON
admet-217	3	5	is	be	VERB
admet-217	3	6	no	no	DET
admet-217	3	7	cure	cure	NOUN
admet-217	3	8	for	for	ADP
admet-217	3	9	these	these	DET
admet-217	3	10	diseases	disease	NOUN
admet-217	3	11	,	,	PUNCT
admet-217	3	12	resulting	result	VERB
admet-217	3	13	in	in	ADP
admet-217	3	14	death	death	NOUN
admet-217	3	15	of	of	ADP
admet-217	3	16	neuron	neuron	NOUN
admet-217	3	17	cells	cell	NOUN
admet-217	3	18	.	.	PUNCT
admet-217	4	1	generally	generally	ADV
admet-217	4	2	,	,	PUNCT
admet-217	4	3	the	the	DET
admet-217	4	4	disease	disease	NOUN
admet-217	4	5	mechanisms	mechanism	NOUN
admet-217	4	6	are	be	AUX
admet-217	4	7	not	not	PART
admet-217	4	8	fully	fully	ADV
admet-217	4	9	understood	understand	VERB
admet-217	4	10	and	and	CCONJ
admet-217	4	11	are	be	AUX
admet-217	4	12	thought	think	VERB
admet-217	4	13	to	to	PART
admet-217	4	14	be	be	AUX
admet-217	4	15	related	relate	VERB
admet-217	4	16	to	to	ADP
admet-217	4	17	genetics	genetic	NOUN
admet-217	4	18	,	,	PUNCT
admet-217	4	19	protein	protein	NOUN
admet-217	4	20	misfolding	misfolding	NOUN
admet-217	4	21	/	/	SYM
admet-217	4	22	degradation	degradation	NOUN
admet-217	4	23	or	or	CCONJ
admet-217	4	24	mitochondrial	mitochondrial	ADJ
admet-217	4	25	dysfunction	dysfunction	NOUN
admet-217	4	26	etc	etc	X
admet-217	4	27	.	.	X
admet-217	5	1	this	this	PRON
admet-217	5	2	introduces	introduce	VERB
admet-217	5	3	further	further	ADJ
admet-217	5	4	complexity	complexity	NOUN
admet-217	5	5	in	in	ADP
admet-217	5	6	the	the	DET
admet-217	5	7	search	search	NOUN
admet-217	5	8	for	for	ADP
admet-217	5	9	therapeutic	therapeutic	ADJ
admet-217	5	10	approaches	approach	NOUN
admet-217	5	11	for	for	ADP
admet-217	5	12	these	these	DET
admet-217	5	13	diseases	disease	NOUN
admet-217	5	14	.	.	PUNCT
admet-217	6	1	in	in	ADP
admet-217	6	2	most	most	ADJ
admet-217	6	3	neurodegenerative	neurodegenerative	ADJ
admet-217	6	4	diseases	disease	NOUN
admet-217	6	5	,	,	PUNCT
admet-217	6	6	the	the	DET
admet-217	6	7	blood	blood	NOUN
admet-217	6	8	–	–	PUNCT
admet-217	6	9	brain	brain	NOUN
admet-217	6	10	barrier	barrier	NOUN
admet-217	6	11	(	(	PUNCT
admet-217	6	12	bbb	bbb	NOUN
admet-217	6	13	)	)	PUNCT
admet-217	6	14	becomes	become	VERB
admet-217	6	15	a	a	DET
admet-217	6	16	hurdle	hurdle	NOUN
admet-217	6	17	in	in	ADP
admet-217	6	18	effective	effective	ADJ
admet-217	6	19	drug	drug	NOUN
admet-217	6	20	delivery	delivery	NOUN
admet-217	6	21	.	.	PUNCT
admet-217	7	1	small	small	ADJ
admet-217	7	2	molecules	molecule	NOUN
admet-217	7	3	or	or	CCONJ
admet-217	7	4	biologics	biologic	NOUN
admet-217	7	5	need	need	VERB
admet-217	7	6	to	to	PART
admet-217	7	7	be	be	AUX
admet-217	7	8	engineered	engineer	VERB
admet-217	7	9	to	to	PART
admet-217	7	10	cross	cross	VERB
admet-217	7	11	the	the	DET
admet-217	7	12	bbb	bbb	NOUN
admet-217	7	13	and	and	CCONJ
admet-217	7	14	reach	reach	VERB
admet-217	7	15	their	their	PRON
admet-217	7	16	target	target	NOUN
admet-217	7	17	in	in	ADP
admet-217	7	18	sufficient	sufficient	ADJ
admet-217	7	19	concentrations	concentration	NOUN
admet-217	7	20	to	to	PART
admet-217	7	21	elicit	elicit	VERB
admet-217	7	22	a	a	DET
admet-217	7	23	pharmacodynamics	pharmacodynamic	NOUN
admet-217	7	24	response	response	NOUN
admet-217	7	25	.	.	PUNCT
admet-217	8	1	the	the	DET
admet-217	8	2	drug	drug	NOUN
admet-217	8	3	concentration	concentration	NOUN
admet-217	8	4	in	in	ADP
admet-217	8	5	the	the	DET
admet-217	8	6	brain	brain	NOUN
admet-217	8	7	is	be	AUX
admet-217	8	8	tricky	tricky	ADJ
admet-217	8	9	to	to	PART
admet-217	8	10	determine	determine	VERB
admet-217	8	11	,	,	PUNCT
admet-217	8	12	while	while	SCONJ
admet-217	8	13	behavioral	behavioral	ADJ
admet-217	8	14	assessment	assessment	NOUN
admet-217	8	15	methods	method	NOUN
admet-217	8	16	are	be	AUX
admet-217	8	17	used	use	VERB
admet-217	8	18	as	as	ADP
admet-217	8	19	surrogates	surrogate	NOUN
admet-217	8	20	for	for	ADP
admet-217	8	21	pharmacodynamics	pharmacodynamic	NOUN
admet-217	8	22	effects	effect	NOUN
admet-217	8	23	.	.	PUNCT
admet-217	9	1	in	in	ADP
admet-217	9	2	this	this	DET
admet-217	9	3	context	context	NOUN
admet-217	9	4	,	,	PUNCT
admet-217	9	5	it	it	PRON
admet-217	9	6	could	could	AUX
admet-217	9	7	be	be	AUX
admet-217	9	8	challenging	challenge	VERB
admet-217	9	9	to	to	PART
admet-217	9	10	establish	establish	VERB
admet-217	9	11	an	an	DET
admet-217	9	12	unambiguous	unambiguous	ADJ
admet-217	9	13	pharmacokinetics	pharmacokinetic	NOUN
admet-217	9	14	/	/	SYM
admet-217	9	15	pharmacodynamics	pharmacodynamic	NOUN
admet-217	9	16	relationship	relationship	NOUN
admet-217	9	17	.	.	PUNCT
admet-217	10	1	in	in	ADP
admet-217	10	2	this	this	DET
admet-217	10	3	special	special	ADJ
admet-217	10	4	issue	issue	NOUN
admet-217	10	5	,	,	PUNCT
admet-217	10	6	some	some	DET
admet-217	10	7	papers	paper	NOUN
admet-217	10	8	reviewed	review	VERB
admet-217	10	9	the	the	DET
admet-217	10	10	mechanisms	mechanism	NOUN
admet-217	10	11	,	,	PUNCT
admet-217	10	12	treatment	treatment	NOUN
admet-217	10	13	approaches	approach	NOUN
admet-217	10	14	,	,	PUNCT
admet-217	10	15	animal	animal	NOUN
admet-217	10	16	models	model	NOUN
admet-217	10	17	used	use	VERB
admet-217	10	18	for	for	ADP
admet-217	10	19	alzheimer	alzheimer	PROPN
admet-217	10	20	’s	’s	PART
admet-217	10	21	disease	disease	NOUN
admet-217	10	22	.	.	PUNCT
admet-217	11	1	a	a	DET
admet-217	11	2	paper	paper	NOUN
admet-217	11	3	reported	report	VERB
admet-217	11	4	a	a	DET
admet-217	11	5	trend	trend	NOUN
admet-217	11	6	model	model	NOUN
admet-217	11	7	for	for	ADP
admet-217	11	8	alzheimer	alzheimer	PROPN
admet-217	11	9	’s	’s	PART
admet-217	11	10	disease	disease	NOUN
admet-217	11	11	mortality	mortality	NOUN
admet-217	11	12	.	.	PUNCT
admet-217	12	1	moreover	moreover	ADV
admet-217	12	2	,	,	PUNCT
admet-217	12	3	two	two	NUM
admet-217	12	4	review	review	NOUN
admet-217	12	5	papers	paper	NOUN
admet-217	12	6	discussed	discuss	VERB
admet-217	12	7	bbb	bbb	NOUN
admet-217	12	8	permeability	permeability	NOUN
admet-217	12	9	and	and	CCONJ
admet-217	12	10	delivery	delivery	NOUN
admet-217	12	11	in	in	ADP
admet-217	12	12	traumatic	traumatic	ADJ
admet-217	12	13	brain	brain	NOUN
admet-217	12	14	injury	injury	NOUN
admet-217	12	15	and	and	CCONJ
admet-217	12	16	in	in	ADP
admet-217	12	17	insulin	insulin	NOUN
admet-217	12	18	delivery	delivery	NOUN
admet-217	12	19	for	for	ADP
admet-217	12	20	alzheimer	alzheimer	PROPN
admet-217	12	21	’s	’s	PART
admet-217	12	22	disease	disease	NOUN
admet-217	12	23	,	,	PUNCT
admet-217	12	24	respectively	respectively	ADV
admet-217	12	25	.	.	PUNCT
admet-217	13	1	other	other	ADJ
admet-217	13	2	papers	paper	NOUN
admet-217	13	3	dealt	deal	VERB
admet-217	13	4	with	with	ADP
admet-217	13	5	cognitive	cognitive	ADJ
admet-217	13	6	deficits	deficit	NOUN
admet-217	13	7	.	.	PUNCT
admet-217	14	1	finally	finally	ADV
admet-217	14	2	,	,	PUNCT
admet-217	14	3	two	two	NUM
admet-217	14	4	other	other	ADJ
admet-217	14	5	papers	paper	NOUN
admet-217	14	6	discussed	discuss	VERB
admet-217	14	7	the	the	DET
admet-217	14	8	use	use	NOUN
admet-217	14	9	of	of	ADP
admet-217	14	10	nanotechnology	nanotechnology	NOUN
admet-217	14	11	platform	platform	NOUN
admet-217	14	12	in	in	ADP
admet-217	14	13	parkinson	parkinson	NOUN
admet-217	14	14	’s	’s	PART
admet-217	14	15	disease	disease	NOUN
admet-217	14	16	and	and	CCONJ
admet-217	14	17	the	the	DET
admet-217	14	18	interactions	interaction	NOUN
admet-217	14	19	of	of	ADP
admet-217	14	20	prion	prion	NOUN
admet-217	14	21	protein	protein	NOUN
admet-217	14	22	with	with	ADP
admet-217	14	23	metal	metal	NOUN
admet-217	14	24	ions	ion	NOUN
admet-217	14	25	.	.	PUNCT
admet-217	15	1	for	for	ADP
admet-217	15	2	the	the	DET
admet-217	15	3	first	first	ADJ
admet-217	15	4	time	time	NOUN
admet-217	15	5	,	,	PUNCT
admet-217	15	6	admet	admet	PROPN
admet-217	15	7	&	&	CCONJ
admet-217	15	8	dmpk	dmpk	PROPN
admet-217	15	9	devotes	devote	VERB
admet-217	15	10	a	a	DET
admet-217	15	11	special	special	ADJ
admet-217	15	12	issue	issue	NOUN
admet-217	15	13	on	on	ADP
admet-217	15	14	medical	medical	ADJ
admet-217	15	15	research	research	NOUN
admet-217	15	16	/	/	SYM
admet-217	15	17	applications	application	NOUN
admet-217	15	18	in	in	ADP
admet-217	15	19	a	a	DET
admet-217	15	20	particular	particular	ADJ
admet-217	15	21	therapeutic	therapeutic	ADJ
admet-217	15	22	area	area	NOUN
admet-217	15	23	,	,	PUNCT
admet-217	15	24	with	with	ADP
admet-217	15	25	the	the	DET
admet-217	15	26	aims	aim	NOUN
admet-217	15	27	to	to	PART
admet-217	15	28	capture	capture	VERB
admet-217	15	29	some	some	PRON
admet-217	15	30	of	of	ADP
admet-217	15	31	the	the	DET
admet-217	15	32	current	current	ADJ
admet-217	15	33	views	view	NOUN
admet-217	15	34	and	and	CCONJ
admet-217	15	35	new	new	ADJ
admet-217	15	36	achievements	achievement	NOUN
admet-217	15	37	in	in	ADP
admet-217	15	38	neurodegenerative	neurodegenerative	ADJ
admet-217	15	39	diseases	disease	NOUN
admet-217	15	40	.	.	PUNCT
admet-217	16	1	it	it	PRON
admet-217	16	2	is	be	AUX
admet-217	16	3	nice	nice	ADJ
admet-217	16	4	to	to	PART
admet-217	16	5	see	see	VERB
admet-217	16	6	some	some	DET
admet-217	16	7	papers	paper	NOUN
admet-217	16	8	discussing	discuss	VERB
admet-217	16	9	cross	cross	ADJ
admet-217	16	10	-	-	ADJ
admet-217	16	11	disciplinary	disciplinary	ADJ
admet-217	16	12	research	research	NOUN
admet-217	16	13	and	and	CCONJ
admet-217	16	14	new	new	ADJ
admet-217	16	15	thoughts	thought	NOUN
admet-217	16	16	to	to	PART
admet-217	16	17	tackle	tackle	VERB
admet-217	16	18	these	these	DET
admet-217	16	19	diseases	disease	NOUN
admet-217	16	20	.	.	PUNCT
admet-217	17	1	hopefully	hopefully	ADV
admet-217	17	2	,	,	PUNCT
admet-217	17	3	we	we	PRON
admet-217	17	4	will	will	AUX
admet-217	17	5	call	call	VERB
admet-217	17	6	for	for	ADP
admet-217	17	7	more	more	ADJ
admet-217	17	8	special	special	ADJ
admet-217	17	9	issues	issue	NOUN
admet-217	17	10	aligned	align	VERB
admet-217	17	11	to	to	ADP
admet-217	17	12	other	other	ADJ
admet-217	17	13	therapeutic	therapeutic	ADJ
admet-217	17	14	areas	area	NOUN
admet-217	17	15	in	in	ADP
admet-217	17	16	due	due	ADJ
admet-217	17	17	course	course	NOUN
admet-217	17	18	.	.	PUNCT
admet-217	18	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-217	18	2	mailto:kin_tam@iapchem.org	mailto:kin_tam@iapchem.org	PROPN