id	sid	tid	token	lemma	pos
admet-2214	1	1	addressing	address	VERB
admet-2214	1	2	barriers	barrier	NOUN
admet-2214	1	3	in	in	ADP
admet-2214	1	4	diffuse	diffuse	ADJ
admet-2214	1	5	intrinsic	intrinsic	ADJ
admet-2214	1	6	pontine	pontine	ADJ
admet-2214	1	7	glioma	glioma	NOUN
admet-2214	1	8	:	:	PUNCT
admet-2214	1	9	the	the	DET
admet-2214	1	10	transformative	transformative	ADJ
admet-2214	1	11	role	role	NOUN
admet-2214	1	12	of	of	ADP
admet-2214	1	13	lipid	lipid	NOUN
admet-2214	1	14	nanoparticulate	nanoparticulate	ADJ
admet-2214	1	15	drug	drug	NOUN
admet-2214	1	16	delivery	delivery	NOUN
admet-2214	1	17	doi	doi	NOUN
admet-2214	1	18	:	:	PUNCT
admet-2214	1	19	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	1	20	403	403	NUM
admet-2214	1	21	admet	admet	PROPN
admet-2214	1	22	&	&	CCONJ
admet-2214	1	23	dmpk	dmpk	PROPN
admet-2214	1	24	12(3	12(3	PROPN
admet-2214	1	25	)	)	PUNCT
admet-2214	1	26	(	(	PUNCT
admet-2214	1	27	2024	2024	NUM
admet-2214	1	28	)	)	PUNCT
admet-2214	1	29	403	403	NUM
admet-2214	1	30	-	-	SYM
admet-2214	1	31	429	429	NUM
admet-2214	1	32	;	;	PUNCT
admet-2214	1	33	doi	doi	NOUN
admet-2214	1	34	:	:	PUNCT
admet-2214	1	35	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	1	36	open	open	ADJ
admet-2214	1	37	access	access	NOUN
admet-2214	1	38	:	:	PUNCT
admet-2214	1	39	issn	issn	PROPN
admet-2214	1	40	:	:	PUNCT
admet-2214	1	41	1848	1848	NUM
admet-2214	1	42	-	-	SYM
admet-2214	1	43	7718	7718	NUM
admet-2214	1	44	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2214	1	45	review	review	VERB
admet-2214	1	46	addressing	address	VERB
admet-2214	1	47	barriers	barrier	NOUN
admet-2214	1	48	in	in	ADP
admet-2214	1	49	diffuse	diffuse	ADJ
admet-2214	1	50	intrinsic	intrinsic	ADJ
admet-2214	1	51	pontine	pontine	ADJ
admet-2214	1	52	glioma	glioma	NOUN
admet-2214	1	53	:	:	PUNCT
admet-2214	1	54	the	the	DET
admet-2214	1	55	transformative	transformative	ADJ
admet-2214	1	56	role	role	NOUN
admet-2214	1	57	of	of	ADP
admet-2214	1	58	lipid	lipid	NOUN
admet-2214	1	59	nanoparticulate	nanoparticulate	ADJ
admet-2214	1	60	drug	drug	NOUN
admet-2214	1	61	delivery	delivery	NOUN
admet-2214	1	62	zenab	zenab	NOUN
admet-2214	1	63	presswala	presswala	PROPN
admet-2214	1	64	,	,	PUNCT
admet-2214	1	65	sheetal	sheetal	PROPN
admet-2214	1	66	acharya	acharya	PROPN
admet-2214	1	67	*	*	PROPN
admet-2214	1	68	and	and	CCONJ
admet-2214	1	69	shreeraj	shreeraj	VERB
admet-2214	1	70	shah	shah	PROPN
admet-2214	1	71	department	department	PROPN
admet-2214	1	72	of	of	ADP
admet-2214	1	73	pharmaceutical	pharmaceutical	NOUN
admet-2214	1	74	technology	technology	NOUN
admet-2214	1	75	,	,	PUNCT
admet-2214	1	76	l.j	l.j	PROPN
admet-2214	1	77	institute	institute	PROPN
admet-2214	1	78	of	of	ADP
admet-2214	1	79	pharmacy	pharmacy	PROPN
admet-2214	1	80	,	,	PUNCT
admet-2214	1	81	lok	lok	PROPN
admet-2214	1	82	jagruti	jagruti	PROPN
admet-2214	1	83	university	university	PROPN
admet-2214	1	84	,	,	PUNCT
admet-2214	1	85	l.j	l.j	PROPN
admet-2214	1	86	campus	campus	NOUN
admet-2214	1	87	,	,	PUNCT
admet-2214	1	88	near	near	ADP
admet-2214	1	89	sarkhejsanand	sarkhejsanand	PROPN
admet-2214	1	90	circle	circle	PROPN
admet-2214	1	91	,	,	PUNCT
admet-2214	1	92	off	off	ADV
admet-2214	1	93	.	.	PUNCT
admet-2214	2	1	s.g	s.g	PROPN
admet-2214	2	2	.	.	PROPN
admet-2214	2	3	road	road	NOUN
admet-2214	2	4	,	,	PUNCT
admet-2214	2	5	ahmedabad-382	ahmedabad-382	VERB
admet-2214	2	6	210	210	NUM
admet-2214	2	7	,	,	PUNCT
admet-2214	2	8	india	india	PROPN
admet-2214	2	9	*	*	PUNCT
admet-2214	2	10	corresponding	correspond	VERB
admet-2214	2	11	author	author	NOUN
admet-2214	2	12	:	:	PUNCT
admet-2214	2	13	e	e	NOUN
admet-2214	2	14	-	-	NOUN
admet-2214	2	15	mail	mail	NOUN
admet-2214	2	16	:	:	PUNCT
admet-2214	2	17	sheetaltarak@gmail.com	sheetaltarak@gmail.com	NUM
admet-2214	2	18	;	;	PUNCT
admet-2214	2	19	tel	tel	PROPN
admet-2214	2	20	.	.	PUNCT
admet-2214	2	21	:	:	PUNCT
admet-2214	3	1	+91	+91	NOUN
admet-2214	3	2	9967117481	9967117481	NUM
admet-2214	3	3	received	receive	VERB
admet-2214	3	4	:	:	PUNCT
admet-2214	3	5	december	december	PROPN
admet-2214	3	6	4	4	NUM
admet-2214	3	7	,	,	PUNCT
admet-2214	3	8	2023	2023	NUM
admet-2214	3	9	;	;	PUNCT
admet-2214	3	10	revised	revise	VERB
admet-2214	3	11	:	:	PUNCT
admet-2214	3	12	june	june	PROPN
admet-2214	3	13	27	27	NUM
admet-2214	3	14	,	,	PUNCT
admet-2214	3	15	2024	2024	NUM
admet-2214	3	16	;	;	PUNCT
admet-2214	3	17	published	publish	VERB
admet-2214	3	18	:	:	PUNCT
admet-2214	3	19	july	july	PROPN
admet-2214	3	20	23	23	NUM
admet-2214	3	21	,	,	PUNCT
admet-2214	3	22	2024	2024	NUM
admet-2214	3	23	abstract	abstract	ADJ
admet-2214	3	24	background	background	NOUN
admet-2214	3	25	and	and	CCONJ
admet-2214	3	26	purpose	purpose	NOUN
admet-2214	3	27	:	:	PUNCT
admet-2214	3	28	the	the	DET
admet-2214	3	29	brainstem	brainstem	NOUN
admet-2214	3	30	tumour	tumour	NOUN
admet-2214	3	31	known	know	VERB
admet-2214	3	32	as	as	ADP
admet-2214	3	33	diffuse	diffuse	PROPN
admet-2214	3	34	intrinsic	intrinsic	ADJ
admet-2214	3	35	pontine	pontine	ADJ
admet-2214	3	36	glioma	glioma	NOUN
admet-2214	3	37	(	(	PUNCT
admet-2214	3	38	dipg	dipg	PROPN
admet-2214	3	39	)	)	PUNCT
admet-2214	3	40	,	,	PUNCT
admet-2214	3	41	also	also	ADV
admet-2214	3	42	known	know	VERB
admet-2214	3	43	as	as	ADP
admet-2214	3	44	pontine	pontine	ADJ
admet-2214	3	45	glioma	glioma	NOUN
admet-2214	3	46	,	,	PUNCT
admet-2214	3	47	infiltrative	infiltrative	ADJ
admet-2214	3	48	brainstem	brainstem	NOUN
admet-2214	3	49	glioma	glioma	NOUN
admet-2214	3	50	is	be	AUX
admet-2214	3	51	uncommon	uncommon	ADJ
admet-2214	3	52	and	and	CCONJ
admet-2214	3	53	virtually	virtually	ADV
admet-2214	3	54	always	always	ADV
admet-2214	3	55	affects	affect	VERB
admet-2214	3	56	children	child	NOUN
admet-2214	3	57	.	.	PUNCT
admet-2214	4	1	a	a	DET
admet-2214	4	2	pontine	pontine	ADJ
admet-2214	4	3	glioma	glioma	NOUN
admet-2214	4	4	develops	develop	VERB
admet-2214	4	5	in	in	ADP
admet-2214	4	6	the	the	DET
admet-2214	4	7	brainstem	brainstem	NOUN
admet-2214	4	8	's	's	PART
admet-2214	4	9	most	most	ADV
admet-2214	4	10	vulnerable	vulnerable	ADJ
admet-2214	4	11	region	region	NOUN
admet-2214	4	12	(	(	PUNCT
admet-2214	4	13	the	the	DET
admet-2214	4	14	"	"	PUNCT
admet-2214	4	15	pons	pon	NOUN
admet-2214	4	16	"	"	PUNCT
admet-2214	4	17	)	)	PUNCT
admet-2214	4	18	,	,	PUNCT
admet-2214	4	19	which	which	PRON
admet-2214	4	20	regulates	regulate	VERB
admet-2214	4	21	a	a	DET
admet-2214	4	22	number	number	NOUN
admet-2214	4	23	of	of	ADP
admet-2214	4	24	vital	vital	ADJ
admet-2214	4	25	processes	process	NOUN
admet-2214	4	26	like	like	ADP
admet-2214	4	27	respiration	respiration	NOUN
admet-2214	4	28	and	and	CCONJ
admet-2214	4	29	blood	blood	NOUN
admet-2214	4	30	pressure	pressure	NOUN
admet-2214	4	31	.	.	PUNCT
admet-2214	5	1	it	it	PRON
admet-2214	5	2	is	be	AUX
admet-2214	5	3	particularly	particularly	ADV
admet-2214	5	4	challenging	challenging	ADJ
admet-2214	5	5	to	to	PART
admet-2214	5	6	treat	treat	VERB
admet-2214	5	7	due	due	ADP
admet-2214	5	8	to	to	ADP
admet-2214	5	9	its	its	PRON
admet-2214	5	10	location	location	NOUN
admet-2214	5	11	and	and	CCONJ
admet-2214	5	12	how	how	SCONJ
admet-2214	5	13	it	it	PRON
admet-2214	5	14	invades	invade	VERB
admet-2214	5	15	healthy	healthy	ADJ
admet-2214	5	16	brain	brain	NOUN
admet-2214	5	17	tissue	tissue	NOUN
admet-2214	5	18	.	.	PUNCT
admet-2214	6	1	the	the	DET
admet-2214	6	2	hunt	hunt	NOUN
admet-2214	6	3	for	for	ADP
admet-2214	6	4	a	a	DET
admet-2214	6	5	solution	solution	NOUN
admet-2214	6	6	is	be	AUX
admet-2214	6	7	continually	continually	ADV
admet-2214	6	8	advancing	advance	VERB
admet-2214	6	9	thanks	thank	NOUN
admet-2214	6	10	to	to	ADP
admet-2214	6	11	advances	advance	NOUN
admet-2214	6	12	in	in	ADP
admet-2214	6	13	modern	modern	ADJ
admet-2214	6	14	medicine	medicine	NOUN
admet-2214	6	15	,	,	PUNCT
admet-2214	6	16	but	but	CCONJ
admet-2214	6	17	the	the	DET
admet-2214	6	18	correct	correct	ADJ
admet-2214	6	19	approach	approach	NOUN
admet-2214	6	20	is	be	AUX
admet-2214	6	21	still	still	ADV
admet-2214	6	22	elusive	elusive	ADJ
admet-2214	6	23	.	.	PUNCT
admet-2214	7	1	with	with	ADP
admet-2214	7	2	a	a	DET
admet-2214	7	3	particular	particular	ADJ
admet-2214	7	4	focus	focus	NOUN
admet-2214	7	5	on	on	ADP
admet-2214	7	6	brain	brain	NOUN
admet-2214	7	7	tumours	tumour	NOUN
admet-2214	7	8	that	that	PRON
admet-2214	7	9	are	be	AUX
admet-2214	7	10	incurable	incurable	ADJ
admet-2214	7	11	or	or	CCONJ
admet-2214	7	12	recur	recur	VERB
admet-2214	7	13	,	,	PUNCT
admet-2214	7	14	research	research	NOUN
admet-2214	7	15	is	be	AUX
admet-2214	7	16	ongoing	ongoing	ADJ
admet-2214	7	17	to	to	PART
admet-2214	7	18	discover	discover	VERB
admet-2214	7	19	fresh	fresh	ADJ
admet-2214	7	20	,	,	PUNCT
admet-2214	7	21	practical	practical	ADJ
admet-2214	7	22	approaches	approach	NOUN
admet-2214	7	23	to	to	PART
admet-2214	7	24	target	target	VERB
admet-2214	7	25	particular	particular	ADJ
admet-2214	7	26	areas	area	NOUN
admet-2214	7	27	of	of	ADP
admet-2214	7	28	the	the	DET
admet-2214	7	29	brain	brain	NOUN
admet-2214	7	30	.	.	PUNCT
admet-2214	8	1	experimental	experimental	ADJ
admet-2214	8	2	approach	approach	NOUN
admet-2214	8	3	:	:	PUNCT
admet-2214	8	4	to	to	PART
admet-2214	8	5	successfully	successfully	ADV
admet-2214	8	6	complete	complete	VERB
admet-2214	8	7	this	this	DET
admet-2214	8	8	task	task	NOUN
admet-2214	8	9	,	,	PUNCT
admet-2214	8	10	a	a	DET
admet-2214	8	11	thorough	thorough	ADJ
admet-2214	8	12	literature	literature	NOUN
admet-2214	8	13	search	search	NOUN
admet-2214	8	14	was	be	AUX
admet-2214	8	15	carried	carry	VERB
admet-2214	8	16	out	out	ADP
admet-2214	8	17	in	in	ADP
admet-2214	8	18	reputable	reputable	ADJ
admet-2214	8	19	databases	database	NOUN
admet-2214	8	20	like	like	ADP
admet-2214	8	21	google	google	PROPN
admet-2214	8	22	scholar	scholar	NOUN
admet-2214	8	23	,	,	PUNCT
admet-2214	8	24	pubmed	pubmed	PROPN
admet-2214	8	25	,	,	PUNCT
admet-2214	8	26	and	and	CCONJ
admet-2214	8	27	sciencedirect	sciencedirect	PROPN
admet-2214	8	28	.	.	PUNCT
admet-2214	9	1	key	key	ADJ
admet-2214	9	2	results	result	NOUN
admet-2214	9	3	:	:	PUNCT
admet-2214	9	4	the	the	DET
admet-2214	9	5	present	present	ADJ
admet-2214	9	6	article	article	NOUN
admet-2214	9	7	provides	provide	VERB
admet-2214	9	8	a	a	DET
admet-2214	9	9	comprehensive	comprehensive	ADJ
admet-2214	9	10	analysis	analysis	NOUN
admet-2214	9	11	of	of	ADP
admet-2214	9	12	the	the	DET
admet-2214	9	13	notable	notable	ADJ
admet-2214	9	14	advantages	advantage	NOUN
admet-2214	9	15	of	of	ADP
admet-2214	9	16	lipid	lipid	ADJ
admet-2214	9	17	nanoparticles	nanoparticle	NOUN
admet-2214	9	18	compared	compare	VERB
admet-2214	9	19	to	to	ADP
admet-2214	9	20	alternative	alternative	ADJ
admet-2214	9	21	nanoparticle	nanoparticle	NOUN
admet-2214	9	22	formulations	formulation	NOUN
admet-2214	9	23	.	.	PUNCT
admet-2214	10	1	the	the	DET
admet-2214	10	2	article	article	NOUN
admet-2214	10	3	delves	delve	VERB
admet-2214	10	4	into	into	ADP
admet-2214	10	5	the	the	DET
admet-2214	10	6	intricate	intricate	ADJ
admet-2214	10	7	realm	realm	NOUN
admet-2214	10	8	of	of	ADP
admet-2214	10	9	diverse	diverse	ADJ
admet-2214	10	10	lipid	lipid	NOUN
admet-2214	10	11	-	-	PUNCT
admet-2214	10	12	based	base	VERB
admet-2214	10	13	nanoparticulate	nanoparticulate	ADJ
admet-2214	10	14	delivery	delivery	NOUN
admet-2214	10	15	systems	system	NOUN
admet-2214	10	16	,	,	PUNCT
admet-2214	10	17	which	which	PRON
admet-2214	10	18	are	be	AUX
admet-2214	10	19	used	use	VERB
admet-2214	10	20	in	in	ADP
admet-2214	10	21	diffuse	diffuse	NOUN
admet-2214	10	22	intrinsic	intrinsic	ADJ
admet-2214	10	23	pontine	pontine	ADJ
admet-2214	10	24	glioma	glioma	NOUN
admet-2214	10	25	(	(	PUNCT
admet-2214	10	26	dipg	dipg	PROPN
admet-2214	10	27	)	)	PUNCT
admet-2214	10	28	which	which	PRON
admet-2214	10	29	thoroughly	thoroughly	ADV
admet-2214	10	30	examines	examine	VERB
admet-2214	10	31	preclinical	preclinical	ADJ
admet-2214	10	32	and	and	CCONJ
admet-2214	10	33	clinical	clinical	ADJ
admet-2214	10	34	studies	study	NOUN
admet-2214	10	35	,	,	PUNCT
admet-2214	10	36	providing	provide	VERB
admet-2214	10	37	a	a	DET
admet-2214	10	38	comprehensive	comprehensive	ADJ
admet-2214	10	39	analysis	analysis	NOUN
admet-2214	10	40	of	of	ADP
admet-2214	10	41	the	the	DET
admet-2214	10	42	effectiveness	effectiveness	NOUN
admet-2214	10	43	and	and	CCONJ
admet-2214	10	44	potential	potential	NOUN
admet-2214	10	45	of	of	ADP
admet-2214	10	46	lipid	lipid	ADJ
admet-2214	10	47	nanoparticles	nanoparticle	NOUN
admet-2214	10	48	in	in	ADP
admet-2214	10	49	driving	drive	VERB
admet-2214	10	50	therapeutic	therapeutic	ADJ
admet-2214	10	51	advancements	advancement	NOUN
admet-2214	10	52	for	for	ADP
admet-2214	10	53	dipg	dipg	NOUN
admet-2214	10	54	.	.	PUNCT
admet-2214	11	1	conclusion	conclusion	NOUN
admet-2214	11	2	:	:	PUNCT
admet-2214	11	3	there	there	PRON
admet-2214	11	4	is	be	VERB
admet-2214	11	5	strong	strong	ADJ
admet-2214	11	6	clinical	clinical	ADJ
admet-2214	11	7	data	datum	NOUN
admet-2214	11	8	to	to	PART
admet-2214	11	9	support	support	VERB
admet-2214	11	10	the	the	DET
admet-2214	11	11	promising	promising	ADJ
admet-2214	11	12	method	method	NOUN
admet-2214	11	13	of	of	ADP
admet-2214	11	14	using	use	VERB
admet-2214	11	15	lipid	lipid	NOUN
admet-2214	11	16	-	-	PUNCT
admet-2214	11	17	based	base	VERB
admet-2214	11	18	nanoparticulate	nanoparticulate	ADJ
admet-2214	11	19	drug	drug	NOUN
admet-2214	11	20	delivery	delivery	NOUN
admet-2214	11	21	for	for	ADP
admet-2214	11	22	brain	brain	NOUN
admet-2214	11	23	cancer	cancer	NOUN
admet-2214	11	24	treatment	treatment	NOUN
admet-2214	11	25	,	,	PUNCT
admet-2214	11	26	which	which	PRON
admet-2214	11	27	shows	show	VERB
admet-2214	11	28	improved	improved	ADJ
admet-2214	11	29	outcomes	outcome	NOUN
admet-2214	11	30	.	.	PUNCT
admet-2214	12	1	©	©	ADP
admet-2214	12	2	2024	2024	NUM
admet-2214	12	3	by	by	ADP
admet-2214	12	4	the	the	DET
admet-2214	12	5	authors	author	NOUN
admet-2214	12	6	.	.	PUNCT
admet-2214	13	1	this	this	DET
admet-2214	13	2	article	article	NOUN
admet-2214	13	3	is	be	AUX
admet-2214	13	4	an	an	DET
admet-2214	13	5	open	open	ADJ
admet-2214	13	6	-	-	PUNCT
admet-2214	13	7	access	access	NOUN
admet-2214	13	8	article	article	NOUN
admet-2214	13	9	distributed	distribute	VERB
admet-2214	13	10	under	under	ADP
admet-2214	13	11	the	the	DET
admet-2214	13	12	terms	term	NOUN
admet-2214	13	13	and	and	CCONJ
admet-2214	13	14	conditions	condition	NOUN
admet-2214	13	15	of	of	ADP
admet-2214	13	16	the	the	DET
admet-2214	13	17	creative	creative	ADJ
admet-2214	13	18	commons	common	NOUN
admet-2214	13	19	attribution	attribution	NOUN
admet-2214	13	20	license	license	NOUN
admet-2214	13	21	(	(	PUNCT
admet-2214	13	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2214	13	23	)	)	PUNCT
admet-2214	13	24	.	.	PUNCT
admet-2214	14	1	keywords	keyword	VERB
admet-2214	14	2	brain	brain	NOUN
admet-2214	14	3	cancer	cancer	NOUN
admet-2214	14	4	,	,	PUNCT
admet-2214	14	5	child	child	NOUN
admet-2214	14	6	cancer	cancer	NOUN
admet-2214	14	7	,	,	PUNCT
admet-2214	14	8	nanoparticles	nanoparticle	NOUN
admet-2214	14	9	,	,	PUNCT
admet-2214	14	10	liposomes	liposome	NOUN
admet-2214	14	11	,	,	PUNCT
admet-2214	14	12	nano	nano	NOUN
admet-2214	14	13	lipid	lipid	NOUN
admet-2214	14	14	carriers	carrier	NOUN
admet-2214	14	15	,	,	PUNCT
admet-2214	14	16	solid	solid	ADJ
admet-2214	14	17	lipid	lipid	NOUN
admet-2214	14	18	nanocarriers	nanocarrier	NOUN
admet-2214	14	19	,	,	PUNCT
admet-2214	14	20	preclinical	preclinical	ADJ
admet-2214	14	21	studies	study	NOUN
admet-2214	14	22	,	,	PUNCT
admet-2214	14	23	clinical	clinical	ADJ
admet-2214	14	24	studies	study	NOUN
admet-2214	14	25	introduction	introduction	VERB
admet-2214	14	26	a	a	DET
admet-2214	14	27	diverse	diverse	ADJ
admet-2214	14	28	subset	subset	NOUN
admet-2214	14	29	of	of	ADP
admet-2214	14	30	gliomas	glioma	NOUN
admet-2214	14	31	called	call	VERB
admet-2214	14	32	brainstem	brainstem	NOUN
admet-2214	14	33	gliomas	glioma	NOUN
admet-2214	14	34	(	(	PUNCT
admet-2214	14	35	bgs	bgs	NOUN
admet-2214	14	36	)	)	PUNCT
admet-2214	14	37	most	most	ADV
admet-2214	14	38	frequently	frequently	ADV
admet-2214	14	39	affects	affect	VERB
admet-2214	14	40	young	young	ADJ
admet-2214	14	41	children	child	NOUN
admet-2214	14	42	.	.	PUNCT
admet-2214	15	1	these	these	DET
admet-2214	15	2	tumors	tumor	NOUN
admet-2214	15	3	are	be	AUX
admet-2214	15	4	known	know	VERB
admet-2214	15	5	as	as	ADP
admet-2214	15	6	gliomas	glioma	NOUN
admet-2214	15	7	because	because	SCONJ
admet-2214	15	8	they	they	PRON
admet-2214	15	9	develop	develop	VERB
admet-2214	15	10	from	from	ADP
admet-2214	15	11	glial	glial	ADJ
admet-2214	15	12	cells	cell	NOUN
admet-2214	15	13	,	,	PUNCT
admet-2214	15	14	a	a	DET
admet-2214	15	15	type	type	NOUN
admet-2214	15	16	of	of	ADP
admet-2214	15	17	supporting	support	VERB
admet-2214	15	18	cell	cell	NOUN
admet-2214	15	19	in	in	ADP
admet-2214	15	20	the	the	DET
admet-2214	15	21	brain	brain	NOUN
admet-2214	15	22	.	.	PUNCT
admet-2214	16	1	on	on	ADP
admet-2214	16	2	the	the	DET
admet-2214	16	3	basis	basis	NOUN
admet-2214	16	4	of	of	ADP
admet-2214	16	5	their	their	PRON
admet-2214	16	6	anatomical	anatomical	ADJ
admet-2214	16	7	structure	structure	NOUN
admet-2214	16	8	and	and	CCONJ
admet-2214	16	9	clinical	clinical	ADJ
admet-2214	16	10	behaviour	behaviour	NOUN
admet-2214	16	11	,	,	PUNCT
admet-2214	16	12	they	they	PRON
admet-2214	16	13	can	can	AUX
admet-2214	16	14	be	be	AUX
admet-2214	16	15	divided	divide	VERB
admet-2214	16	16	into	into	ADP
admet-2214	16	17	groups	group	NOUN
admet-2214	16	18	[	[	X
admet-2214	16	19	1,2	1,2	NUM
admet-2214	16	20	]	]	PUNCT
admet-2214	16	21	.	.	PUNCT
admet-2214	17	1	gliomas	glioma	NOUN
admet-2214	17	2	are	be	AUX
admet-2214	17	3	divided	divide	VERB
admet-2214	17	4	into	into	ADP
admet-2214	17	5	four	four	NUM
admet-2214	17	6	grades	grade	NOUN
admet-2214	17	7	by	by	ADP
admet-2214	17	8	the	the	DET
admet-2214	17	9	world	world	PROPN
admet-2214	17	10	health	health	PROPN
admet-2214	17	11	organization	organization	NOUN
admet-2214	17	12	(	(	PUNCT
admet-2214	17	13	who	who	PRON
admet-2214	17	14	)	)	PUNCT
admet-2214	17	15	based	base	VERB
admet-2214	17	16	on	on	ADP
admet-2214	17	17	histopathologic	histopathologic	ADJ
admet-2214	17	18	characteristics	characteristic	NOUN
admet-2214	17	19	like	like	ADP
admet-2214	17	20	necrosis	necrosis	NOUN
admet-2214	17	21	,	,	PUNCT
admet-2214	17	22	micro	micro	ADJ
admet-2214	17	23	vascular	vascular	ADJ
admet-2214	17	24	proliferation	proliferation	NOUN
admet-2214	17	25	,	,	PUNCT
admet-2214	17	26	cytological	cytological	ADJ
admet-2214	17	27	atypia	atypia	PROPN
admet-2214	17	28	,	,	PUNCT
admet-2214	17	29	anaplasia	anaplasia	PROPN
admet-2214	17	30	and	and	CCONJ
admet-2214	17	31	mitotic	mitotic	ADJ
admet-2214	17	32	index	index	NOUN
admet-2214	17	33	,	,	PUNCT
admet-2214	17	34	as	as	SCONJ
admet-2214	17	35	shown	show	VERB
admet-2214	17	36	in	in	ADP
admet-2214	17	37	figure	figure	NOUN
admet-2214	17	38	1	1	NUM
admet-2214	18	1	[	[	X
admet-2214	18	2	3,4	3,4	NUM
admet-2214	18	3	]	]	PUNCT
admet-2214	18	4	.	.	PUNCT
admet-2214	19	1	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	19	2	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	19	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-2214	19	4	mailto:sheetaltarak@gmail.com	mailto:sheetaltarak@gmail.com	X
admet-2214	19	5	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2214	19	6	z.	z.	PROPN
admet-2214	19	7	presswala	presswala	PROPN
admet-2214	19	8	et	et	PROPN
admet-2214	19	9	al	al	PROPN
admet-2214	19	10	.	.	PROPN
admet-2214	19	11	admet	admet	PROPN
admet-2214	19	12	&	&	CCONJ
admet-2214	19	13	dmpk	dmpk	PROPN
admet-2214	19	14	12(3	12(3	PROPN
admet-2214	19	15	)	)	PUNCT
admet-2214	19	16	(	(	PUNCT
admet-2214	19	17	2024	2024	NUM
admet-2214	19	18	)	)	PUNCT
admet-2214	19	19	403	403	NUM
admet-2214	19	20	-	-	SYM
admet-2214	19	21	429	429	NUM
admet-2214	19	22	404	404	NUM
admet-2214	19	23	figure	figure	NOUN
admet-2214	19	24	1	1	NUM
admet-2214	19	25	.	.	PUNCT
admet-2214	20	1	classification	classification	NOUN
admet-2214	20	2	of	of	ADP
admet-2214	20	3	brain	brain	NOUN
admet-2214	20	4	gliomas	glioma	NOUN
admet-2214	20	5	according	accord	VERB
admet-2214	20	6	to	to	ADP
admet-2214	20	7	the	the	DET
admet-2214	20	8	world	world	PROPN
admet-2214	20	9	health	health	NOUN
admet-2214	20	10	organization	organization	NOUN
admet-2214	20	11	in	in	ADP
admet-2214	20	12	2016	2016	NUM
admet-2214	20	13	,	,	PUNCT
admet-2214	20	14	the	the	DET
admet-2214	20	15	world	world	PROPN
admet-2214	20	16	health	health	NOUN
admet-2214	20	17	organization	organization	NOUN
admet-2214	20	18	(	(	PUNCT
admet-2214	20	19	who	who	PRON
admet-2214	20	20	)	)	PUNCT
admet-2214	20	21	implemented	implement	VERB
admet-2214	20	22	a	a	DET
admet-2214	20	23	significant	significant	ADJ
admet-2214	20	24	update	update	NOUN
admet-2214	20	25	to	to	ADP
admet-2214	20	26	the	the	DET
admet-2214	20	27	diagnostic	diagnostic	ADJ
admet-2214	20	28	criteria	criterion	NOUN
admet-2214	20	29	for	for	ADP
admet-2214	20	30	infiltrating	infiltrate	VERB
admet-2214	20	31	gliomas	glioma	NOUN
admet-2214	20	32	.	.	PUNCT
admet-2214	21	1	this	this	DET
admet-2214	21	2	update	update	NOUN
admet-2214	21	3	introduced	introduce	VERB
admet-2214	21	4	molecular	molecular	ADJ
admet-2214	21	5	markers	marker	NOUN
admet-2214	21	6	into	into	ADP
admet-2214	21	7	the	the	DET
admet-2214	21	8	classification	classification	NOUN
admet-2214	21	9	system	system	NOUN
admet-2214	21	10	,	,	PUNCT
admet-2214	21	11	including	include	VERB
admet-2214	21	12	histone	histone	NOUN
admet-2214	21	13	alterations	alteration	NOUN
admet-2214	21	14	,	,	PUNCT
admet-2214	21	15	1p/19q	1p/19q	NOUN
admet-2214	21	16	chromosome	chromosome	NOUN
admet-2214	21	17	status	status	NOUN
admet-2214	21	18	,	,	PUNCT
admet-2214	21	19	and	and	CCONJ
admet-2214	21	20	isocitrate	isocitrate	ADJ
admet-2214	21	21	dehydrogenase	dehydrogenase	NOUN
admet-2214	21	22	mutations	mutation	NOUN
admet-2214	21	23	.	.	PUNCT
admet-2214	22	1	despite	despite	SCONJ
admet-2214	22	2	the	the	DET
admet-2214	22	3	remarkable	remarkable	ADJ
admet-2214	22	4	progress	progress	NOUN
admet-2214	22	5	made	make	VERB
admet-2214	22	6	in	in	ADP
admet-2214	22	7	the	the	DET
admet-2214	22	8	field	field	NOUN
admet-2214	22	9	,	,	PUNCT
admet-2214	22	10	it	it	PRON
admet-2214	22	11	is	be	AUX
admet-2214	22	12	disheartening	dishearten	VERB
admet-2214	22	13	to	to	PART
admet-2214	22	14	acknowledge	acknowledge	VERB
admet-2214	22	15	that	that	SCONJ
admet-2214	22	16	the	the	DET
admet-2214	22	17	outlook	outlook	NOUN
admet-2214	22	18	for	for	ADP
admet-2214	22	19	individuals	individual	NOUN
admet-2214	22	20	diagnosed	diagnose	VERB
admet-2214	22	21	with	with	ADP
admet-2214	22	22	malignant	malignant	ADJ
admet-2214	22	23	or	or	CCONJ
admet-2214	22	24	high	high	ADJ
admet-2214	22	25	-	-	PUNCT
admet-2214	22	26	grade	grade	NOUN
admet-2214	22	27	(	(	PUNCT
admet-2214	22	28	iii	iii	X
admet-2214	22	29	and	and	CCONJ
admet-2214	22	30	iv	iv	X
admet-2214	22	31	)	)	PUNCT
admet-2214	22	32	gliomas	glioma	NOUN
admet-2214	22	33	remains	remain	VERB
admet-2214	22	34	exceedingly	exceedingly	ADV
admet-2214	22	35	bleak	bleak	ADJ
admet-2214	22	36	[	[	X
admet-2214	22	37	3,5	3,5	NUM
admet-2214	22	38	]	]	PUNCT
admet-2214	22	39	.	.	PUNCT
admet-2214	23	1	diffuse	diffuse	VERB
admet-2214	23	2	intrinsic	intrinsic	ADJ
admet-2214	23	3	pontine	pontine	ADJ
admet-2214	23	4	glioma	glioma	NOUN
admet-2214	23	5	(	(	PUNCT
admet-2214	23	6	dipg	dipg	PROPN
admet-2214	23	7	)	)	PUNCT
admet-2214	23	8	is	be	AUX
admet-2214	23	9	a	a	DET
admet-2214	23	10	pediatric	pediatric	ADJ
admet-2214	23	11	malignant	malignant	ADJ
admet-2214	23	12	tumour	tumour	NOUN
admet-2214	23	13	that	that	PRON
admet-2214	23	14	develops	develop	VERB
admet-2214	23	15	widely	widely	ADV
admet-2214	23	16	in	in	ADP
admet-2214	23	17	the	the	DET
admet-2214	23	18	stem	stem	NOUN
admet-2214	23	19	region	region	NOUN
admet-2214	23	20	of	of	ADP
admet-2214	23	21	the	the	DET
admet-2214	23	22	brain	brain	NOUN
admet-2214	23	23	,	,	PUNCT
admet-2214	23	24	which	which	PRON
admet-2214	23	25	is	be	AUX
admet-2214	23	26	called	call	VERB
admet-2214	23	27	pons	pon	NOUN
admet-2214	23	28	.	.	PUNCT
admet-2214	24	1	the	the	DET
admet-2214	24	2	usual	usual	ADJ
admet-2214	24	3	age	age	NOUN
admet-2214	24	4	at	at	ADP
admet-2214	24	5	diagnosis	diagnosis	NOUN
admet-2214	24	6	for	for	ADP
admet-2214	24	7	this	this	DET
admet-2214	24	8	unsettling	unsettling	ADJ
admet-2214	24	9	illness	illness	NOUN
admet-2214	24	10	is	be	AUX
admet-2214	24	11	6	6	NUM
admet-2214	24	12	-	-	SYM
admet-2214	24	13	7	7	NUM
admet-2214	24	14	years	year	NOUN
admet-2214	24	15	old	old	ADJ
admet-2214	24	16	,	,	PUNCT
admet-2214	24	17	and	and	CCONJ
admet-2214	24	18	adults	adult	NOUN
admet-2214	24	19	are	be	AUX
admet-2214	24	20	rarely	rarely	ADV
admet-2214	24	21	diagnosed	diagnose	VERB
admet-2214	24	22	with	with	ADP
admet-2214	24	23	it	it	PRON
admet-2214	24	24	.	.	PUNCT
admet-2214	25	1	less	less	ADJ
admet-2214	25	2	than	than	ADP
admet-2214	25	3	10	10	NUM
admet-2214	25	4	%	%	NOUN
admet-2214	25	5	of	of	ADP
admet-2214	25	6	patients	patient	NOUN
admet-2214	25	7	remain	remain	VERB
admet-2214	25	8	alive	alive	ADJ
admet-2214	25	9	following	follow	VERB
admet-2214	25	10	their	their	PRON
admet-2214	25	11	delay	delay	NOUN
admet-2214	25	12	in	in	ADP
admet-2214	25	13	diagnoses	diagnosis	NOUN
admet-2214	25	14	for	for	ADP
admet-2214	25	15	more	more	ADJ
admet-2214	25	16	than	than	ADP
admet-2214	25	17	two	two	NUM
admet-2214	25	18	years	year	NOUN
admet-2214	25	19	due	due	ADP
admet-2214	25	20	to	to	ADP
admet-2214	25	21	the	the	DET
admet-2214	25	22	location	location	NOUN
admet-2214	25	23	and	and	CCONJ
admet-2214	25	24	existing	exist	VERB
admet-2214	25	25	treatment	treatment	NOUN
admet-2214	25	26	choices	choice	NOUN
admet-2214	25	27	.	.	PUNCT
admet-2214	26	1	approximately	approximately	ADV
admet-2214	26	2	80	80	NUM
admet-2214	26	3	%	%	NOUN
admet-2214	26	4	of	of	ADP
admet-2214	26	5	all	all	DET
admet-2214	26	6	kinds	kind	NOUN
admet-2214	26	7	of	of	ADP
admet-2214	26	8	pediatric	pediatric	ADJ
admet-2214	26	9	brain	brain	NOUN
admet-2214	26	10	tumours	tumour	NOUN
admet-2214	26	11	that	that	PRON
admet-2214	26	12	develop	develop	VERB
admet-2214	26	13	in	in	ADP
admet-2214	26	14	the	the	DET
admet-2214	26	15	brainstem	brainstem	NOUN
admet-2214	26	16	are	be	AUX
admet-2214	26	17	dipgs	dipgs	ADJ
admet-2214	26	18	[	[	X
admet-2214	26	19	6	6	NUM
admet-2214	26	20	-	-	SYM
admet-2214	26	21	9	9	NUM
admet-2214	26	22	]	]	PUNCT
admet-2214	26	23	.	.	PUNCT
admet-2214	27	1	unfortunately	unfortunately	ADV
admet-2214	27	2	,	,	PUNCT
admet-2214	27	3	dipg	dipg	PROPN
admet-2214	27	4	has	have	VERB
admet-2214	27	5	a	a	DET
admet-2214	27	6	dismal	dismal	ADJ
admet-2214	27	7	prognosis	prognosis	NOUN
admet-2214	27	8	and	and	CCONJ
admet-2214	27	9	,	,	PUNCT
admet-2214	27	10	regardless	regardless	ADV
admet-2214	27	11	of	of	ADP
admet-2214	27	12	the	the	DET
admet-2214	27	13	type	type	NOUN
admet-2214	27	14	of	of	ADP
admet-2214	27	15	treatment	treatment	NOUN
admet-2214	27	16	used	use	VERB
admet-2214	27	17	,	,	PUNCT
admet-2214	27	18	the	the	DET
admet-2214	27	19	median	median	ADJ
admet-2214	27	20	survival	survival	NOUN
admet-2214	27	21	time	time	NOUN
admet-2214	27	22	is	be	AUX
admet-2214	27	23	typically	typically	ADV
admet-2214	27	24	less	less	ADJ
admet-2214	27	25	than	than	ADP
admet-2214	27	26	16	16	NUM
admet-2214	27	27	-	-	SYM
admet-2214	27	28	24	24	NUM
admet-2214	27	29	months	month	NOUN
admet-2214	28	1	[	[	X
admet-2214	28	2	1	1	NUM
admet-2214	28	3	]	]	PUNCT
admet-2214	28	4	.	.	PUNCT
admet-2214	29	1	history	history	NOUN
admet-2214	29	2	of	of	ADP
admet-2214	29	3	dipg	dipg	NOUN
admet-2214	29	4	since	since	SCONJ
admet-2214	29	5	the	the	DET
admet-2214	29	6	name	name	NOUN
admet-2214	29	7	"	"	PUNCT
admet-2214	29	8	glioma	glioma	NOUN
admet-2214	29	9	"	"	PUNCT
admet-2214	29	10	was	be	AUX
admet-2214	29	11	first	first	ADV
admet-2214	29	12	used	use	VERB
admet-2214	29	13	over	over	ADP
admet-2214	29	14	150	150	NUM
admet-2214	29	15	years	year	NOUN
admet-2214	29	16	ago	ago	ADV
admet-2214	29	17	,	,	PUNCT
admet-2214	29	18	numerous	numerous	ADJ
admet-2214	29	19	gliomas	glioma	NOUN
admet-2214	29	20	have	have	AUX
admet-2214	29	21	been	be	AUX
admet-2214	29	22	identified	identify	VERB
admet-2214	29	23	and	and	CCONJ
admet-2214	29	24	described	describe	VERB
admet-2214	29	25	[	[	X
admet-2214	29	26	10	10	NUM
admet-2214	29	27	]	]	PUNCT
admet-2214	29	28	.	.	PUNCT
admet-2214	30	1	although	although	SCONJ
admet-2214	30	2	dipg	dipg	NOUN
admet-2214	30	3	has	have	AUX
admet-2214	30	4	existed	exist	VERB
admet-2214	30	5	throughout	throughout	ADP
admet-2214	30	6	human	human	ADJ
admet-2214	30	7	history	history	NOUN
admet-2214	30	8	,	,	PUNCT
admet-2214	30	9	it	it	PRON
admet-2214	30	10	was	be	AUX
admet-2214	30	11	n't	not	PART
admet-2214	30	12	until	until	ADP
admet-2214	30	13	the	the	DET
admet-2214	30	14	1920s	1920s	NUM
admet-2214	30	15	that	that	PRON
admet-2214	30	16	it	it	PRON
admet-2214	30	17	was	be	AUX
admet-2214	30	18	first	first	ADV
admet-2214	30	19	mentioned	mention	VERB
admet-2214	30	20	in	in	ADP
admet-2214	30	21	english	english	PROPN
admet-2214	30	22	medical	medical	PROPN
admet-2214	30	23	literature	literature	PROPN
admet-2214	30	24	.	.	PUNCT
admet-2214	31	1	at	at	ADP
admet-2214	31	2	the	the	DET
admet-2214	31	3	time	time	NOUN
admet-2214	31	4	,	,	PUNCT
admet-2214	31	5	there	there	PRON
admet-2214	31	6	was	be	VERB
admet-2214	31	7	no	no	DET
admet-2214	31	8	neuroimaging	neuroimaging	NOUN
admet-2214	31	9	,	,	PUNCT
admet-2214	31	10	thus	thus	ADV
admet-2214	31	11	,	,	PUNCT
admet-2214	31	12	a	a	DET
admet-2214	31	13	patient	patient	NOUN
admet-2214	31	14	with	with	ADP
admet-2214	31	15	the	the	DET
admet-2214	31	16	classic	classic	ADJ
admet-2214	31	17	dipg	dipg	NOUN
admet-2214	31	18	symptoms	symptom	NOUN
admet-2214	31	19	(	(	PUNCT
admet-2214	31	20	in	in	ADP
admet-2214	31	21	-	-	PUNCT
admet-2214	31	22	turned	turn	VERB
admet-2214	31	23	eye	eye	NOUN
admet-2214	31	24	,	,	PUNCT
admet-2214	31	25	weakness	weakness	NOUN
admet-2214	31	26	on	on	ADP
admet-2214	31	27	one	one	NUM
admet-2214	31	28	side	side	NOUN
admet-2214	31	29	)	)	PUNCT
admet-2214	31	30	was	be	AUX
admet-2214	31	31	diagnosed	diagnose	VERB
admet-2214	31	32	with	with	ADP
admet-2214	31	33	the	the	DET
admet-2214	31	34	disease	disease	NOUN
admet-2214	31	35	solely	solely	ADV
admet-2214	31	36	by	by	ADP
admet-2214	31	37	physical	physical	ADJ
admet-2214	31	38	examination	examination	NOUN
admet-2214	31	39	.	.	PUNCT
admet-2214	32	1	radiation	radiation	NOUN
admet-2214	32	2	was	be	AUX
admet-2214	32	3	increasingly	increasingly	ADV
admet-2214	32	4	used	use	VERB
admet-2214	32	5	to	to	PART
admet-2214	32	6	treat	treat	VERB
admet-2214	32	7	cancer	cancer	NOUN
admet-2214	32	8	from	from	ADP
admet-2214	32	9	the	the	DET
admet-2214	32	10	1930s	1930	NOUN
admet-2214	32	11	through	through	ADP
admet-2214	32	12	the	the	DET
admet-2214	32	13	1950s	1950s	NUM
admet-2214	32	14	,	,	PUNCT
admet-2214	32	15	and	and	CCONJ
admet-2214	32	16	it	it	PRON
admet-2214	32	17	was	be	AUX
admet-2214	32	18	ultimately	ultimately	ADV
admet-2214	32	19	discovered	discover	VERB
admet-2214	32	20	to	to	PART
admet-2214	32	21	be	be	AUX
admet-2214	32	22	effective	effective	ADJ
admet-2214	32	23	against	against	ADP
admet-2214	32	24	several	several	ADJ
admet-2214	32	25	cns	cns	NOUN
admet-2214	32	26	tumours	tumour	NOUN
admet-2214	32	27	.	.	PUNCT
admet-2214	33	1	further	far	ADV
admet-2214	33	2	,	,	PUNCT
admet-2214	33	3	we	we	PRON
admet-2214	33	4	have	have	AUX
admet-2214	33	5	discussed	discuss	VERB
admet-2214	33	6	a	a	DET
admet-2214	33	7	few	few	ADJ
admet-2214	33	8	dipg	dipg	NOUN
admet-2214	33	9	facts	fact	NOUN
admet-2214	33	10	in	in	ADP
admet-2214	33	11	figure	figure	NOUN
admet-2214	33	12	2	2	NUM
admet-2214	34	1	[	[	X
admet-2214	34	2	11	11	NUM
admet-2214	34	3	]	]	PUNCT
admet-2214	34	4	.	.	PUNCT
admet-2214	35	1	epidemiology	epidemiology	NOUN
admet-2214	35	2	and	and	CCONJ
admet-2214	35	3	diagnosis	diagnosis	VERB
admet-2214	35	4	the	the	DET
admet-2214	35	5	tumor	tumor	NOUN
admet-2214	35	6	is	be	AUX
admet-2214	35	7	aggressive	aggressive	ADJ
admet-2214	35	8	,	,	PUNCT
admet-2214	35	9	as	as	SCONJ
admet-2214	35	10	evidenced	evidence	VERB
admet-2214	35	11	by	by	ADP
admet-2214	35	12	the	the	DET
admet-2214	35	13	fact	fact	NOUN
admet-2214	35	14	that	that	SCONJ
admet-2214	35	15	the	the	DET
admet-2214	35	16	majority	majority	NOUN
admet-2214	35	17	of	of	ADP
admet-2214	35	18	children	child	NOUN
admet-2214	35	19	survive	survive	VERB
admet-2214	35	20	for	for	ADP
admet-2214	35	21	less	less	ADJ
admet-2214	35	22	than	than	ADP
admet-2214	35	23	a	a	PRON
admet-2214	35	24	year	year	NOUN
admet-2214	35	25	.	.	PUNCT
admet-2214	36	1	figure	figure	NOUN
admet-2214	36	2	3a	3a	PROPN
admet-2214	36	3	explains	explain	VERB
admet-2214	36	4	cancer	cancer	NOUN
admet-2214	36	5	arising	arise	VERB
admet-2214	36	6	from	from	ADP
admet-2214	36	7	pons	pon	NOUN
admet-2214	36	8	and	and	CCONJ
admet-2214	36	9	figure	figure	VERB
admet-2214	36	10	3b	3b	NOUN
admet-2214	36	11	shows	show	VERB
admet-2214	36	12	the	the	DET
admet-2214	36	13	pictorial	pictorial	ADJ
admet-2214	36	14	image	image	NOUN
admet-2214	36	15	of	of	ADP
admet-2214	36	16	cancer	cancer	NOUN
admet-2214	36	17	cells	cell	NOUN
admet-2214	36	18	.	.	PUNCT
admet-2214	37	1	dipgs	dipgs	PROPN
admet-2214	37	2	can	can	AUX
admet-2214	37	3	not	not	PART
admet-2214	37	4	be	be	AUX
admet-2214	37	5	surgically	surgically	ADV
admet-2214	37	6	resected	resect	VERB
admet-2214	37	7	due	due	ADP
admet-2214	37	8	to	to	ADP
admet-2214	37	9	their	their	PRON
admet-2214	37	10	infiltrative	infiltrative	ADJ
admet-2214	37	11	nature	nature	NOUN
admet-2214	37	12	and	and	CCONJ
admet-2214	37	13	localization	localization	NOUN
admet-2214	37	14	in	in	ADP
admet-2214	37	15	the	the	DET
admet-2214	37	16	brainstem	brainstem	NOUN
admet-2214	37	17	.	.	PUNCT
admet-2214	38	1	in	in	ADP
admet-2214	38	2	the	the	DET
admet-2214	38	3	unites	unite	NOUN
admet-2214	38	4	states	state	NOUN
admet-2214	38	5	,	,	PUNCT
admet-2214	38	6	roughly	roughly	ADV
admet-2214	38	7	300	300	NUM
admet-2214	38	8	-	-	SYM
admet-2214	38	9	350	350	NUM
admet-2214	38	10	new	new	ADJ
admet-2214	38	11	cases	case	NOUN
admet-2214	38	12	of	of	ADP
admet-2214	38	13	dipg	dipg	NOUN
admet-2214	38	14	are	be	AUX
admet-2214	38	15	identified	identify	VERB
admet-2214	38	16	each	each	DET
admet-2214	38	17	year	year	NOUN
admet-2214	39	1	[	[	X
admet-2214	39	2	12	12	NUM
admet-2214	39	3	]	]	PUNCT
admet-2214	39	4	.	.	PUNCT
admet-2214	40	1	patients	patient	NOUN
admet-2214	40	2	typically	typically	ADV
admet-2214	40	3	exhibit	exhibit	VERB
admet-2214	40	4	brainstem	brainstem	NOUN
admet-2214	40	5	syndromes	syndrome	NOUN
admet-2214	40	6	,	,	PUNCT
admet-2214	40	7	which	which	PRON
admet-2214	40	8	can	can	AUX
admet-2214	40	9	occur	occur	VERB
admet-2214	40	10	singly	singly	ADV
admet-2214	40	11	or	or	CCONJ
admet-2214	40	12	in	in	ADP
admet-2214	40	13	combination	combination	NOUN
admet-2214	40	14	and	and	CCONJ
admet-2214	40	15	include	include	VERB
admet-2214	40	16	ataxia	ataxia	NOUN
admet-2214	40	17	,	,	PUNCT
admet-2214	40	18	long	long	ADJ
admet-2214	40	19	tract	tract	NOUN
admet-2214	40	20	symptoms	symptom	NOUN
admet-2214	40	21	,	,	PUNCT
admet-2214	40	22	and	and	CCONJ
admet-2214	40	23	cranial	cranial	ADJ
admet-2214	40	24	nerve	nerve	NOUN
admet-2214	40	25	dysfunction	dysfunction	NOUN
admet-2214	41	1	[	[	X
admet-2214	41	2	1,6,13	1,6,13	NUM
admet-2214	41	3	]	]	PUNCT
admet-2214	41	4	.	.	PUNCT
admet-2214	42	1	admet	admet	PROPN
admet-2214	42	2	&	&	CCONJ
admet-2214	42	3	dmpk	dmpk	PROPN
admet-2214	42	4	12(3	12(3	PROPN
admet-2214	42	5	)	)	PUNCT
admet-2214	42	6	(	(	PUNCT
admet-2214	42	7	2024	2024	NUM
admet-2214	42	8	)	)	PUNCT
admet-2214	42	9	403	403	NUM
admet-2214	42	10	-	-	SYM
admet-2214	42	11	429	429	NUM
admet-2214	42	12	addressing	address	VERB
admet-2214	42	13	barriers	barrier	NOUN
admet-2214	42	14	in	in	ADP
admet-2214	42	15	diffuse	diffuse	ADJ
admet-2214	42	16	intrinsic	intrinsic	ADJ
admet-2214	42	17	pontine	pontine	ADJ
admet-2214	42	18	glioma	glioma	NOUN
admet-2214	42	19	doi	doi	NOUN
admet-2214	42	20	:	:	PUNCT
admet-2214	42	21	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	X
admet-2214	42	22	405	405	NUM
admet-2214	42	23	figure	figure	NOUN
admet-2214	42	24	2	2	NUM
admet-2214	42	25	.	.	X
admet-2214	42	26	history	history	NOUN
admet-2214	42	27	and	and	CCONJ
admet-2214	42	28	facts	fact	NOUN
admet-2214	42	29	of	of	ADP
admet-2214	42	30	dipg	dipg	NOUN
admet-2214	42	31	a	a	DET
admet-2214	42	32	b	b	NUM
admet-2214	42	33	figure	figure	NOUN
admet-2214	42	34	3	3	NUM
admet-2214	42	35	.	.	PUNCT
admet-2214	43	1	a	a	DET
admet-2214	43	2	cancer	cancer	NOUN
admet-2214	43	3	arising	arise	VERB
admet-2214	43	4	from	from	ADP
admet-2214	43	5	pons	pon	NOUN
admet-2214	43	6	;	;	PUNCT
admet-2214	43	7	b	b	X
admet-2214	43	8	pictorial	pictorial	ADJ
admet-2214	43	9	image	image	NOUN
admet-2214	43	10	of	of	ADP
admet-2214	43	11	cancer	cancer	NOUN
admet-2214	43	12	cells	cell	NOUN
admet-2214	43	13	.	.	PUNCT
admet-2214	44	1	the	the	DET
admet-2214	44	2	preferred	preferred	ADJ
admet-2214	44	3	diagnostic	diagnostic	ADJ
admet-2214	44	4	method	method	NOUN
admet-2214	44	5	is	be	AUX
admet-2214	44	6	mri	mri	NOUN
admet-2214	44	7	(	(	PUNCT
admet-2214	44	8	magnetic	magnetic	ADJ
admet-2214	44	9	resonance	resonance	NOUN
admet-2214	44	10	imaging	imaging	NOUN
admet-2214	44	11	)	)	PUNCT
admet-2214	44	12	,	,	PUNCT
admet-2214	44	13	with	with	ADP
admet-2214	44	14	as	as	ADV
admet-2214	44	15	well	well	ADV
admet-2214	44	16	as	as	ADP
admet-2214	44	17	without	without	ADP
admet-2214	44	18	an	an	DET
admet-2214	44	19	intravenous	intravenous	ADJ
admet-2214	44	20	agent	agent	NOUN
admet-2214	44	21	.	.	PUNCT
admet-2214	45	1	a	a	DET
admet-2214	45	2	high	high	ADJ
admet-2214	45	3	-	-	PUNCT
admet-2214	45	4	signal	signal	NOUN
admet-2214	45	5	lesion	lesion	NOUN
admet-2214	45	6	that	that	PRON
admet-2214	45	7	occupies	occupy	VERB
admet-2214	45	8	at	at	ADV
admet-2214	45	9	least	least	ADJ
admet-2214	45	10	two	two	NUM
admet-2214	45	11	-	-	PUNCT
admet-2214	45	12	thirds	third	NOUN
admet-2214	45	13	of	of	ADP
admet-2214	45	14	the	the	DET
admet-2214	45	15	pons	pon	NOUN
admet-2214	45	16	and	and	CCONJ
admet-2214	45	17	frequently	frequently	ADV
admet-2214	45	18	spreads	spread	VERB
admet-2214	45	19	laterally	laterally	ADV
admet-2214	45	20	into	into	ADP
admet-2214	45	21	the	the	DET
admet-2214	45	22	cerebellar	cerebellar	ADJ
admet-2214	45	23	hemispheres	hemisphere	NOUN
admet-2214	45	24	and	and	CCONJ
admet-2214	45	25	peduncles	peduncle	NOUN
admet-2214	45	26	as	as	ADV
admet-2214	45	27	well	well	ADV
admet-2214	45	28	as	as	ADP
admet-2214	45	29	vertically	vertically	ADV
admet-2214	45	30	into	into	ADP
admet-2214	45	31	the	the	DET
admet-2214	45	32	midbrain	midbrain	NOUN
admet-2214	45	33	and	and	CCONJ
admet-2214	45	34	medulla	medulla	NOUN
admet-2214	45	35	[	[	X
admet-2214	45	36	1,14	1,14	NUM
admet-2214	45	37	]	]	PUNCT
admet-2214	45	38	.	.	PUNCT
admet-2214	46	1	contrast	contrast	NOUN
admet-2214	46	2	enhancement	enhancement	NOUN
admet-2214	46	3	often	often	ADV
admet-2214	46	4	only	only	ADV
admet-2214	46	5	accounts	account	VERB
admet-2214	46	6	for	for	ADP
admet-2214	46	7	0	0	NUM
admet-2214	46	8	to	to	PART
admet-2214	46	9	25	25	NUM
admet-2214	46	10	%	%	NOUN
admet-2214	46	11	of	of	ADP
admet-2214	46	12	the	the	DET
admet-2214	46	13	tumour	tumour	NOUN
admet-2214	46	14	volume	volume	NOUN
admet-2214	46	15	,	,	PUNCT
admet-2214	46	16	making	make	VERB
admet-2214	46	17	it	it	PRON
admet-2214	46	18	a	a	DET
admet-2214	46	19	less	less	ADV
admet-2214	46	20	noticeable	noticeable	ADJ
admet-2214	46	21	feature	feature	NOUN
admet-2214	46	22	.	.	PUNCT
admet-2214	47	1	cysts	cyst	NOUN
admet-2214	47	2	are	be	AUX
admet-2214	47	3	small	small	ADJ
admet-2214	47	4	bumps	bump	NOUN
admet-2214	47	5	found	find	VERB
admet-2214	47	6	uncommon	uncommon	ADJ
admet-2214	47	7	;	;	PUNCT
admet-2214	47	8	however	however	ADV
admet-2214	47	9	,	,	PUNCT
admet-2214	47	10	necrosis	necrosis	NOUN
admet-2214	47	11	,	,	PUNCT
admet-2214	47	12	a	a	DET
admet-2214	47	13	premature	premature	ADJ
admet-2214	47	14	cell	cell	NOUN
admet-2214	47	15	death	death	NOUN
admet-2214	47	16	,	,	PUNCT
admet-2214	47	17	can	can	AUX
admet-2214	47	18	occur	occur	VERB
admet-2214	47	19	.	.	PUNCT
admet-2214	48	1	diffusion	diffusion	NOUN
admet-2214	48	2	-	-	PUNCT
admet-2214	48	3	weighted	weight	VERB
admet-2214	48	4	mri	mri	NOUN
admet-2214	48	5	often	often	ADV
admet-2214	48	6	does	do	AUX
admet-2214	48	7	not	not	PART
admet-2214	48	8	reveal	reveal	VERB
admet-2214	48	9	restricted	restrict	VERB
admet-2214	48	10	water	water	NOUN
admet-2214	48	11	diffusion	diffusion	NOUN
admet-2214	48	12	.	.	PUNCT
admet-2214	49	1	advanced	advanced	ADJ
admet-2214	49	2	neuroimaging	neuroimaging	NOUN
admet-2214	49	3	reveals	reveal	VERB
admet-2214	49	4	that	that	SCONJ
admet-2214	49	5	dipgs	dipgs	NOUN
admet-2214	49	6	have	have	VERB
admet-2214	49	7	low	low	ADJ
admet-2214	49	8	cerebral	cerebral	ADJ
admet-2214	49	9	blood	blood	NOUN
admet-2214	49	10	volume	volume	NOUN
admet-2214	49	11	and	and	CCONJ
admet-2214	49	12	hypoperfusion	hypoperfusion	NOUN
admet-2214	49	13	,	,	PUNCT
admet-2214	49	14	and	and	CCONJ
admet-2214	49	15	mri	mri	NOUN
admet-2214	49	16	reveals	reveal	VERB
admet-2214	49	17	a	a	DET
admet-2214	49	18	moderate	moderate	ADJ
admet-2214	49	19	rise	rise	NOUN
admet-2214	49	20	in	in	ADP
admet-2214	49	21	choline	choline	NOUN
admet-2214	49	22	levels	level	NOUN
admet-2214	49	23	and	and	CCONJ
admet-2214	49	24	a	a	DET
admet-2214	49	25	fall	fall	NOUN
admet-2214	49	26	in	in	ADP
admet-2214	49	27	acetylaspartate	acetylaspartate	NOUN
admet-2214	49	28	levels	level	NOUN
admet-2214	49	29	[	[	X
admet-2214	49	30	15	15	NUM
admet-2214	49	31	]	]	PUNCT
admet-2214	49	32	.	.	PUNCT
admet-2214	50	1	because	because	SCONJ
admet-2214	50	2	of	of	ADP
admet-2214	50	3	the	the	DET
admet-2214	50	4	associated	associated	ADJ
admet-2214	50	5	risk	risk	NOUN
admet-2214	50	6	of	of	ADP
admet-2214	50	7	morbidity	morbidity	NOUN
admet-2214	50	8	and	and	CCONJ
admet-2214	50	9	lack	lack	NOUN
admet-2214	50	10	of	of	ADP
admet-2214	50	11	therapeutic	therapeutic	ADJ
admet-2214	50	12	efficacy	efficacy	NOUN
admet-2214	50	13	,	,	PUNCT
admet-2214	50	14	a	a	DET
admet-2214	50	15	tissue	tissue	NOUN
admet-2214	50	16	biopsy	biopsy	NOUN
admet-2214	50	17	is	be	AUX
admet-2214	50	18	typically	typically	ADV
admet-2214	50	19	not	not	PART
admet-2214	50	20	necessary	necessary	ADJ
admet-2214	50	21	in	in	ADP
admet-2214	50	22	cases	case	NOUN
admet-2214	50	23	where	where	SCONJ
admet-2214	50	24	the	the	DET
admet-2214	50	25	mri	mri	NOUN
admet-2214	50	26	appearance	appearance	NOUN
admet-2214	50	27	of	of	ADP
admet-2214	50	28	dipg	dipg	NOUN
admet-2214	50	29	is	be	AUX
admet-2214	50	30	so	so	ADV
admet-2214	50	31	distinctive	distinctive	ADJ
admet-2214	50	32	[	[	X
admet-2214	50	33	1	1	NUM
admet-2214	50	34	]	]	PUNCT
admet-2214	50	35	.	.	PUNCT
admet-2214	51	1	molecular	molecular	ADJ
admet-2214	51	2	characterization	characterization	NOUN
admet-2214	51	3	h3k27	h3k27	NOUN
admet-2214	51	4	m	m	PROPN
admet-2214	51	5	,	,	PUNCT
admet-2214	51	6	mycn	mycn	NOUN
admet-2214	51	7	,	,	PUNCT
admet-2214	51	8	and	and	CCONJ
admet-2214	51	9	silent	silent	ADJ
admet-2214	51	10	are	be	AUX
admet-2214	51	11	the	the	DET
admet-2214	51	12	three	three	NUM
admet-2214	51	13	molecular	molecular	ADJ
admet-2214	51	14	defines	define	NOUN
admet-2214	51	15	groups	group	NOUN
admet-2214	51	16	of	of	ADP
admet-2214	51	17	dipgss	dipgss	NOUN
admet-2214	51	18	[	[	X
admet-2214	51	19	6,16	6,16	NOUN
admet-2214	51	20	]	]	X
admet-2214	51	21	.	.	PUNCT
admet-2214	52	1	nearly	nearly	ADV
admet-2214	52	2	80	80	NUM
admet-2214	52	3	%	%	NOUN
admet-2214	52	4	of	of	ADP
admet-2214	52	5	dipgs	dipgs	NOUN
admet-2214	52	6	carry	carry	VERB
admet-2214	52	7	h3	h3	NOUN
admet-2214	52	8	mutations	mutation	NOUN
admet-2214	52	9	,	,	PUNCT
admet-2214	52	10	as	as	SCONJ
admet-2214	52	11	depicted	depict	VERB
admet-2214	52	12	in	in	ADP
admet-2214	52	13	figure	figure	NOUN
admet-2214	52	14	4	4	NUM
admet-2214	52	15	,	,	PUNCT
admet-2214	52	16	compared	compare	VERB
admet-2214	52	17	to	to	ADP
admet-2214	52	18	around	around	ADP
admet-2214	52	19	35	35	NUM
admet-2214	52	20	%	%	NOUN
admet-2214	52	21	of	of	ADP
admet-2214	52	22	other	other	ADJ
admet-2214	52	23	brain	brain	NOUN
admet-2214	52	24	tumours	tumour	NOUN
admet-2214	52	25	[	[	X
admet-2214	52	26	17	17	NUM
admet-2214	52	27	]	]	PUNCT
admet-2214	52	28	.	.	PUNCT
admet-2214	53	1	h3.1	h3.1	ADJ
admet-2214	53	2	and	and	CCONJ
admet-2214	53	3	h3.3	h3.3	NOUN
admet-2214	53	4	are	be	AUX
admet-2214	53	5	the	the	DET
admet-2214	53	6	isoforms	isoform	NOUN
admet-2214	53	7	,	,	PUNCT
admet-2214	53	8	which	which	PRON
admet-2214	53	9	are	be	AUX
admet-2214	53	10	expressed	express	VERB
admet-2214	53	11	by	by	ADP
admet-2214	53	12	the	the	DET
admet-2214	53	13	genes	gene	NOUN
admet-2214	53	14	hist1h3b	hist1h3b	PRON
admet-2214	53	15	and	and	CCONJ
admet-2214	53	16	h3f3a	h3f3a	NOUN
admet-2214	53	17	,	,	PUNCT
admet-2214	53	18	respectively	respectively	ADV
admet-2214	53	19	,	,	PUNCT
admet-2214	53	20	and	and	CCONJ
admet-2214	53	21	have	have	VERB
admet-2214	53	22	methionine	methionine	NOUN
admet-2214	53	23	in	in	ADP
admet-2214	53	24	place	place	NOUN
admet-2214	53	25	of	of	ADP
admet-2214	53	26	lysine	lysine	NOUN
admet-2214	53	27	as	as	ADP
admet-2214	53	28	a	a	DET
admet-2214	53	29	result	result	NOUN
admet-2214	53	30	of	of	ADP
admet-2214	53	31	the	the	DET
admet-2214	53	32	histone	histone	NOUN
admet-2214	53	33	mutation	mutation	NOUN
admet-2214	53	34	h3k27	h3k27	PRON
admet-2214	53	35	m	m	PROPN
admet-2214	53	36	[	[	X
admet-2214	53	37	18,19	18,19	NUM
admet-2214	53	38	]	]	X
admet-2214	53	39	.	.	PUNCT
admet-2214	54	1	the	the	DET
admet-2214	54	2	survival	survival	NOUN
admet-2214	54	3	,	,	PUNCT
admet-2214	54	4	phenotype	phenotype	NOUN
admet-2214	54	5	,	,	PUNCT
admet-2214	54	6	and	and	CCONJ
admet-2214	54	7	clinical	clinical	ADJ
admet-2214	54	8	effects	effect	NOUN
admet-2214	54	9	of	of	ADP
admet-2214	54	10	the	the	DET
admet-2214	54	11	histone	histone	NOUN
admet-2214	54	12	mutations	mutation	NOUN
admet-2214	54	13	in	in	ADP
admet-2214	54	14	h3.1	h3.1	ADJ
admet-2214	54	15	and	and	CCONJ
admet-2214	54	16	h3.3	h3.3	NOUN
admet-2214	54	17	differ	differ	VERB
admet-2214	54	18	slightly	slightly	ADV
admet-2214	54	19	from	from	ADP
admet-2214	54	20	each	each	DET
admet-2214	54	21	other	other	ADJ
admet-2214	54	22	[	[	X
admet-2214	54	23	20	20	NUM
admet-2214	54	24	]	]	PUNCT
admet-2214	54	25	.	.	PUNCT
admet-2214	55	1	histone	histone	NOUN
admet-2214	55	2	alterations	alteration	NOUN
admet-2214	55	3	in	in	ADP
admet-2214	55	4	the	the	DET
admet-2214	55	5	h3.1	h3.1	ADJ
admet-2214	55	6	subunit	subunit	NOUN
admet-2214	55	7	are	be	AUX
admet-2214	55	8	frequently	frequently	ADV
admet-2214	55	9	linked	link	VERB
admet-2214	55	10	to	to	ADP
admet-2214	55	11	marginally	marginally	ADV
admet-2214	55	12	increased	increase	VERB
admet-2214	55	13	survival	survival	NOUN
admet-2214	55	14	and	and	CCONJ
admet-2214	55	15	decreased	decrease	VERB
admet-2214	55	16	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	55	17	z.	z.	PROPN
admet-2214	55	18	presswala	presswala	PROPN
admet-2214	55	19	et	et	PROPN
admet-2214	55	20	al	al	PROPN
admet-2214	55	21	.	.	PROPN
admet-2214	55	22	admet	admet	PROPN
admet-2214	55	23	&	&	CCONJ
admet-2214	55	24	dmpk	dmpk	PROPN
admet-2214	55	25	12(3	12(3	PROPN
admet-2214	55	26	)	)	PUNCT
admet-2214	55	27	(	(	PUNCT
admet-2214	55	28	2024	2024	NUM
admet-2214	55	29	)	)	PUNCT
admet-2214	55	30	403	403	NUM
admet-2214	55	31	-	-	SYM
admet-2214	55	32	429	429	NUM
admet-2214	55	33	406	406	NUM
admet-2214	55	34	metastases	metastasis	NOUN
admet-2214	55	35	.	.	PUNCT
admet-2214	56	1	regardless	regardless	ADV
admet-2214	56	2	of	of	ADP
admet-2214	56	3	the	the	DET
admet-2214	56	4	isoform	isoform	NOUN
admet-2214	56	5	affected	affect	VERB
admet-2214	56	6	,	,	PUNCT
admet-2214	56	7	the	the	DET
admet-2214	56	8	h3k27	h3k27	NOUN
admet-2214	56	9	m	m	NOUN
admet-2214	56	10	is	be	AUX
admet-2214	56	11	generally	generally	ADV
admet-2214	56	12	linked	link	VERB
admet-2214	56	13	to	to	ADP
admet-2214	56	14	significantly	significantly	ADV
admet-2214	56	15	inferior	inferior	ADJ
admet-2214	56	16	results	result	NOUN
admet-2214	56	17	compared	compare	VERB
admet-2214	56	18	to	to	ADP
admet-2214	56	19	other	other	ADJ
admet-2214	56	20	h3	h3	NOUN
admet-2214	56	21	wild	wild	ADJ
admet-2214	56	22	-	-	PUNCT
admet-2214	56	23	type	type	NOUN
admet-2214	56	24	cases	case	NOUN
admet-2214	56	25	[	[	X
admet-2214	56	26	21,22	21,22	NOUN
admet-2214	56	27	]	]	X
admet-2214	56	28	.	.	PUNCT
admet-2214	57	1	by	by	ADP
admet-2214	57	2	inhibiting	inhibit	VERB
admet-2214	57	3	polycomb	polycomb	ADJ
admet-2214	57	4	repressive	repressive	ADJ
admet-2214	57	5	complex	complex	ADJ
admet-2214	57	6	2	2	NUM
admet-2214	57	7	(	(	PUNCT
admet-2214	57	8	prc2	prc2	NOUN
admet-2214	57	9	)	)	PUNCT
admet-2214	57	10	,	,	PUNCT
admet-2214	57	11	a	a	DET
admet-2214	57	12	gene	gene	NOUN
admet-2214	57	13	belonging	belong	VERB
admet-2214	57	14	to	to	ADP
admet-2214	57	15	the	the	DET
admet-2214	57	16	polycomb	polycomb	ADJ
admet-2214	57	17	group	group	NOUN
admet-2214	57	18	that	that	PRON
admet-2214	57	19	directly	directly	ADV
admet-2214	57	20	and	and	CCONJ
admet-2214	57	21	indirectly	indirectly	ADV
admet-2214	57	22	controls	control	VERB
admet-2214	57	23	the	the	DET
admet-2214	57	24	dna	dna	PROPN
admet-2214	57	25	damage	damage	NOUN
admet-2214	57	26	response	response	NOUN
admet-2214	57	27	and	and	CCONJ
admet-2214	57	28	functions	function	NOUN
admet-2214	57	29	as	as	ADP
admet-2214	57	30	an	an	DET
admet-2214	57	31	anticancer	anticancer	NOUN
admet-2214	57	32	barrier	barrier	NOUN
admet-2214	57	33	,	,	PUNCT
admet-2214	57	34	this	this	DET
admet-2214	57	35	mutation	mutation	NOUN
admet-2214	57	36	results	result	VERB
admet-2214	57	37	in	in	ADP
admet-2214	57	38	the	the	DET
admet-2214	57	39	loss	loss	NOUN
admet-2214	57	40	of	of	ADP
admet-2214	57	41	histone	histone	NOUN
admet-2214	57	42	trimethylation	trimethylation	NOUN
admet-2214	57	43	and	and	CCONJ
admet-2214	57	44	,	,	PUNCT
admet-2214	57	45	as	as	ADP
admet-2214	57	46	a	a	DET
admet-2214	57	47	result	result	NOUN
admet-2214	57	48	,	,	PUNCT
admet-2214	57	49	epigenetic	epigenetic	ADJ
admet-2214	57	50	silencing	silence	VERB
admet-2214	57	51	[	[	X
admet-2214	57	52	18,19	18,19	NUM
admet-2214	57	53	]	]	PUNCT
admet-2214	57	54	.	.	PUNCT
admet-2214	58	1	dipgs	dipgs	PROPN
admet-2214	58	2	have	have	VERB
admet-2214	58	3	myc	myc	PROPN
admet-2214	58	4	and	and	CCONJ
admet-2214	58	5	mycn	mycn	PROPN
admet-2214	58	6	mutations	mutation	NOUN
admet-2214	58	7	,	,	PUNCT
admet-2214	58	8	which	which	PRON
admet-2214	58	9	function	function	VERB
admet-2214	58	10	as	as	SCONJ
admet-2214	58	11	transcriptional	transcriptional	ADJ
admet-2214	58	12	regulators	regulator	NOUN
admet-2214	58	13	to	to	PART
admet-2214	58	14	improve	improve	VERB
admet-2214	58	15	gene	gene	NOUN
admet-2214	58	16	expression	expression	NOUN
admet-2214	58	17	throughout	throughout	ADP
admet-2214	58	18	the	the	DET
admet-2214	58	19	genome	genome	NOUN
admet-2214	58	20	[	[	X
admet-2214	58	21	6,17	6,17	NOUN
admet-2214	58	22	]	]	PUNCT
admet-2214	58	23	.	.	PUNCT
admet-2214	59	1	apart	apart	ADV
admet-2214	59	2	from	from	ADP
admet-2214	59	3	this	this	PRON
admet-2214	59	4	,	,	PUNCT
admet-2214	59	5	other	other	ADJ
admet-2214	59	6	mutations	mutation	NOUN
admet-2214	59	7	were	be	AUX
admet-2214	59	8	found	find	VERB
admet-2214	59	9	,	,	PUNCT
admet-2214	59	10	such	such	ADJ
admet-2214	59	11	as	as	ADP
admet-2214	59	12	acvr1	acvr1	PROPN
admet-2214	59	13	,	,	PUNCT
admet-2214	59	14	tp53	tp53	PROPN
admet-2214	59	15	,	,	PUNCT
admet-2214	59	16	pik3ri	pik3ri	PROPN
admet-2214	59	17	,	,	PUNCT
admet-2214	59	18	and	and	CCONJ
admet-2214	59	19	pik3ca	pik3ca	NOUN
admet-2214	59	20	[	[	X
admet-2214	59	21	6	6	NUM
admet-2214	59	22	]	]	PUNCT
admet-2214	59	23	.	.	PUNCT
admet-2214	60	1	figure	figure	NOUN
admet-2214	60	2	4	4	NUM
admet-2214	60	3	.	.	PUNCT
admet-2214	61	1	the	the	DET
admet-2214	61	2	k27	k27	PROPN
admet-2214	61	3	m	m	PROPN
admet-2214	61	4	mutation	mutation	NOUN
admet-2214	61	5	in	in	ADP
admet-2214	61	6	histone	histone	NOUN
admet-2214	61	7	h3	h3	NOUN
admet-2214	61	8	is	be	AUX
admet-2214	61	9	a	a	DET
admet-2214	61	10	characteristic	characteristic	ADJ
admet-2214	61	11	feature	feature	NOUN
admet-2214	61	12	of	of	ADP
admet-2214	61	13	dipgs	dipgs	NOUN
admet-2214	61	14	.	.	PUNCT
admet-2214	62	1	all	all	DET
admet-2214	62	2	relevant	relevant	ADJ
admet-2214	62	3	information	information	NOUN
admet-2214	62	4	about	about	ADP
admet-2214	62	5	dipg	dipg	NOUN
admet-2214	62	6	,	,	PUNCT
admet-2214	62	7	including	include	VERB
admet-2214	62	8	its	its	PRON
admet-2214	62	9	ongoing	ongoing	ADJ
admet-2214	62	10	treatments	treatment	NOUN
admet-2214	62	11	,	,	PUNCT
admet-2214	62	12	new	new	ADJ
admet-2214	62	13	understandings	understanding	NOUN
admet-2214	62	14	,	,	PUNCT
admet-2214	62	15	mutations	mutation	NOUN
admet-2214	62	16	,	,	PUNCT
admet-2214	62	17	and	and	CCONJ
admet-2214	62	18	diagnostic	diagnostic	ADJ
admet-2214	62	19	methods	method	NOUN
admet-2214	62	20	,	,	PUNCT
admet-2214	62	21	has	have	AUX
admet-2214	62	22	been	be	AUX
admet-2214	62	23	compiled	compile	VERB
admet-2214	62	24	in	in	ADP
admet-2214	62	25	table	table	NOUN
admet-2214	62	26	1	1	NUM
admet-2214	62	27	.	.	PUNCT
admet-2214	62	28	table	table	NOUN
admet-2214	62	29	1	1	NUM
admet-2214	62	30	.	.	PUNCT
admet-2214	63	1	clinical	clinical	ADJ
admet-2214	63	2	,	,	PUNCT
admet-2214	63	3	pathological	pathological	ADJ
admet-2214	63	4	,	,	PUNCT
admet-2214	63	5	and	and	CCONJ
admet-2214	63	6	genetic	genetic	ADJ
admet-2214	63	7	characteristics	characteristic	NOUN
admet-2214	63	8	of	of	ADP
admet-2214	63	9	dipg	dipg	NOUN
admet-2214	63	10	are	be	AUX
admet-2214	63	11	summarized	summarize	VERB
admet-2214	63	12	in	in	ADP
admet-2214	63	13	the	the	DET
admet-2214	63	14	following	follow	VERB
admet-2214	63	15	table	table	NOUN
admet-2214	63	16	[	[	X
admet-2214	63	17	1,6,23,24	1,6,23,24	NUM
admet-2214	63	18	]	]	PUNCT
admet-2214	63	19	location	location	NOUN
admet-2214	63	20	pons	pon	NOUN
admet-2214	63	21	prognosis	prognosis	NOUN
admet-2214	63	22	median	median	ADJ
admet-2214	63	23	overall	overall	ADJ
admet-2214	63	24	survival	survival	NOUN
admet-2214	63	25	is	be	AUX
admet-2214	63	26	8	8	NUM
admet-2214	63	27	-	-	SYM
admet-2214	63	28	12	12	NUM
admet-2214	63	29	months	month	NOUN
admet-2214	63	30	age	age	NOUN
admet-2214	63	31	of	of	ADP
admet-2214	63	32	diagnosis	diagnosis	NOUN
admet-2214	63	33	6	6	NUM
admet-2214	63	34	-	-	SYM
admet-2214	63	35	7	7	NUM
admet-2214	63	36	years	year	NOUN
admet-2214	63	37	prevelance	prevelance	NOUN
admet-2214	63	38	10	10	NUM
admet-2214	63	39	-	-	SYM
admet-2214	63	40	20	20	NUM
admet-2214	63	41	%	%	NOUN
admet-2214	63	42	of	of	ADP
admet-2214	63	43	all	all	DET
admet-2214	63	44	paderaite	paderaite	ADJ
admet-2214	63	45	brain	brain	NOUN
admet-2214	63	46	tumours	tumours	NOUN
admet-2214	63	47	,	,	PUNCT
admet-2214	63	48	80	80	NUM
admet-2214	63	49	%	%	NOUN
admet-2214	63	50	of	of	ADP
admet-2214	63	51	all	all	DET
admet-2214	63	52	pediatric	pediatric	ADJ
admet-2214	63	53	brainstem	brainstem	NOUN
admet-2214	63	54	tumors	tumor	NOUN
admet-2214	63	55	clinical	clinical	ADJ
admet-2214	63	56	presentation	presentation	NOUN
admet-2214	63	57	>	>	X
admet-2214	63	58	50	50	NUM
admet-2214	63	59	%	%	NOUN
admet-2214	63	60	classic	classic	ADJ
admet-2214	63	61	symptoms	symptom	NOUN
admet-2214	63	62	:	:	PUNCT
admet-2214	63	63	long	long	ADJ
admet-2214	63	64	tract	tract	NOUN
admet-2214	63	65	and	and	CCONJ
admet-2214	63	66	cerebellar	cerebellar	ADJ
admet-2214	63	67	signs	sign	NOUN
admet-2214	63	68	,	,	PUNCT
admet-2214	63	69	cranial	cranial	ADJ
admet-2214	63	70	nerve	nerve	NOUN
admet-2214	63	71	palsies	palsy	NOUN
admet-2214	63	72	.	.	PUNCT
admet-2214	64	1	cranial	cranial	ADJ
admet-2214	64	2	nerve	nerve	NOUN
admet-2214	64	3	vi	vi	PROPN
admet-2214	64	4	and	and	CCONJ
admet-2214	64	5	vii	vii	PROPN
admet-2214	64	6	dysfunction	dysfunction	NOUN
admet-2214	64	7	obstructive	obstructive	ADJ
admet-2214	64	8	hydrocephalus	hydrocephalus	CCONJ
admet-2214	64	9	diagnostic	diagnostic	ADJ
admet-2214	64	10	tools	tool	NOUN
admet-2214	64	11	mri	mri	NOUN
admet-2214	64	12	(	(	PUNCT
admet-2214	64	13	common	common	ADJ
admet-2214	64	14	)	)	PUNCT
admet-2214	64	15	stereotactic	stereotactic	ADJ
admet-2214	64	16	biopsy	biopsy	NOUN
admet-2214	64	17	and	and	CCONJ
admet-2214	64	18	histological	histological	ADJ
admet-2214	64	19	review	review	NOUN
admet-2214	64	20	,	,	PUNCT
admet-2214	64	21	molecular	molecular	ADJ
admet-2214	64	22	testing	testing	NOUN
admet-2214	64	23	.	.	PUNCT
admet-2214	65	1	symptom	symptom	NOUN
admet-2214	65	2	onset	onset	NOUN
admet-2214	65	3	rapid	rapid	ADJ
admet-2214	65	4	,	,	PUNCT
admet-2214	65	5	usually	usually	ADV
admet-2214	65	6	1	1	NUM
admet-2214	65	7	month	month	NOUN
admet-2214	65	8	before	before	SCONJ
admet-2214	65	9	symptoms	symptom	NOUN
admet-2214	65	10	are	be	AUX
admet-2214	65	11	noticed	notice	VERB
admet-2214	65	12	.	.	PUNCT
admet-2214	66	1	molecular	molecular	ADJ
admet-2214	66	2	testing	testing	NOUN
admet-2214	66	3	next	next	ADJ
admet-2214	66	4	generation	generation	NOUN
admet-2214	66	5	sequencing	sequence	VERB
admet-2214	66	6	,	,	PUNCT
admet-2214	66	7	dna	dna	PROPN
admet-2214	66	8	microarrays	microarray	VERB
admet-2214	66	9	molecular	molecular	ADJ
admet-2214	66	10	subgroups	subgroup	NOUN
admet-2214	66	11	h3k27	h3k27	NOUN
admet-2214	66	12	m	m	PROPN
admet-2214	66	13	,	,	PUNCT
admet-2214	66	14	mycn	mycn	NOUN
admet-2214	66	15	and	and	CCONJ
admet-2214	66	16	silent	silent	ADJ
admet-2214	66	17	mutations	mutation	NOUN
admet-2214	66	18	histone	histone	NOUN
admet-2214	66	19	3	3	NUM
admet-2214	66	20	(	(	PUNCT
admet-2214	66	21	h3	h3	NOUN
admet-2214	66	22	)	)	PUNCT
admet-2214	66	23	80	80	NUM
admet-2214	66	24	%	%	NOUN
admet-2214	66	25	significantly	significantly	ADV
admet-2214	66	26	worse	bad	ADJ
admet-2214	66	27	outcomes	outcome	NOUN
admet-2214	66	28	vs	vs	ADP
admet-2214	66	29	h3	h3	NOUN
admet-2214	66	30	wild	wild	ADJ
admet-2214	66	31	-	-	PUNCT
admet-2214	66	32	type	type	NOUN
admet-2214	66	33	h3k27	h3k27	NOUN
admet-2214	66	34	m	m	VERB
admet-2214	66	35	isoforms	isoform	NOUN
admet-2214	66	36	h3.1	h3.1	ADJ
admet-2214	66	37	and	and	CCONJ
admet-2214	66	38	h3.3	h3.3	NOUN
admet-2214	66	39	acvr1	acvr1	NOUN
admet-2214	66	40	–	–	PUNCT
admet-2214	66	41	30	30	NUM
admet-2214	66	42	%	%	NOUN
admet-2214	66	43	co	co	NOUN
admet-2214	66	44	segregates	segregate	VERB
admet-2214	66	45	with	with	ADP
admet-2214	66	46	h3.1	h3.1	PROPN
admet-2214	66	47	,	,	PUNCT
admet-2214	66	48	facilitates	facilitate	VERB
admet-2214	66	49	early	early	ADJ
admet-2214	66	50	tumor	tumor	NOUN
admet-2214	66	51	progression	progression	NOUN
admet-2214	66	52	tp53	tp53	PROPN
admet-2214	66	53	20	20	NUM
admet-2214	66	54	-	-	SYM
admet-2214	66	55	40	40	NUM
admet-2214	66	56	%	%	NOUN
admet-2214	66	57	often	often	ADV
admet-2214	66	58	coincident	coincident	VERB
admet-2214	66	59	with	with	ADP
admet-2214	66	60	pdgfra	pdgfra	NOUN
admet-2214	66	61	amplification	amplification	NOUN
admet-2214	66	62	pik3ri	pik3ri	NOUN
admet-2214	66	63	and	and	CCONJ
admet-2214	66	64	pik3ca	pik3ca	VERB
admet-2214	66	65	pi3k	pi3k	NOUN
admet-2214	66	66	pathway	pathway	NOUN
admet-2214	66	67	oncogenes	oncogene	VERB
admet-2214	66	68	myc	myc	PROPN
admet-2214	66	69	and	and	CCONJ
admet-2214	66	70	mycn	mycn	NOUN
admet-2214	66	71	aberrations	aberration	NOUN
admet-2214	66	72	transcriptional	transcriptional	ADJ
admet-2214	66	73	regulators	regulator	NOUN
admet-2214	66	74	,	,	PUNCT
admet-2214	66	75	enhance	enhance	VERB
admet-2214	66	76	overall	overall	ADJ
admet-2214	66	77	gene	gene	NOUN
admet-2214	66	78	expression	expression	NOUN
admet-2214	66	79	histology	histology	NOUN
admet-2214	66	80	common	common	ADJ
admet-2214	66	81	:	:	PUNCT
admet-2214	66	82	high	high	ADJ
admet-2214	66	83	-	-	PUNCT
admet-2214	66	84	grade	grade	NOUN
admet-2214	66	85	astrocytic	astrocytic	ADJ
admet-2214	66	86	,	,	PUNCT
admet-2214	66	87	increased	increase	VERB
admet-2214	66	88	mitotic	mitotic	ADJ
admet-2214	66	89	activity	activity	NOUN
admet-2214	66	90	,	,	PUNCT
admet-2214	66	91	microvascular	microvascular	ADJ
admet-2214	66	92	proliferation	proliferation	NOUN
admet-2214	66	93	and	and	CCONJ
admet-2214	66	94	/or	/or	ADP
admet-2214	66	95	necrosis	necrosis	NOUN
admet-2214	66	96	rare	rare	ADJ
admet-2214	66	97	:	:	PUNCT
admet-2214	66	98	lower	low	ADJ
admet-2214	66	99	-	-	PUNCT
admet-2214	66	100	grade	grade	NOUN
admet-2214	66	101	histology	histology	NOUN
admet-2214	66	102	,	,	PUNCT
admet-2214	66	103	overall	overall	ADJ
admet-2214	66	104	bland	bland	ADJ
admet-2214	66	105	cytology	cytology	NOUN
admet-2214	66	106	.	.	PUNCT
admet-2214	67	1	immunohistochemistry	immunohistochemistry	PROPN
admet-2214	67	2	gfap	gfap	PROPN
admet-2214	67	3	,	,	PUNCT
admet-2214	67	4	atrx	atrx	PROPN
admet-2214	67	5	,	,	PUNCT
admet-2214	67	6	p53	p53	NOUN
admet-2214	67	7	,	,	PUNCT
admet-2214	67	8	neurofilament	neurofilament	NOUN
admet-2214	67	9	,	,	PUNCT
admet-2214	67	10	ki-67	ki-67	ADJ
admet-2214	67	11	immunostains	immunostain	NOUN
admet-2214	67	12	targeted	target	VERB
admet-2214	67	13	antibodies	antibody	NOUN
admet-2214	67	14	for	for	ADP
admet-2214	67	15	h3k27	h3k27	PROPN
admet-2214	67	16	m	m	PROPN
admet-2214	67	17	,	,	PUNCT
admet-2214	67	18	idhir132h	idhir132h	PROPN
admet-2214	67	19	current	current	ADJ
admet-2214	67	20	treatment	treatment	NOUN
admet-2214	67	21	only	only	ADV
admet-2214	67	22	fractionated	fractionate	VERB
admet-2214	67	23	radiation	radiation	NOUN
admet-2214	67	24	at	at	ADP
admet-2214	67	25	the	the	DET
admet-2214	67	26	dose	dose	NOUN
admet-2214	67	27	of	of	ADP
admet-2214	67	28	54	54	NUM
admet-2214	67	29	-	-	SYM
admet-2214	67	30	59	59	NUM
admet-2214	67	31	gy	gy	NOUN
admet-2214	67	32	or	or	CCONJ
admet-2214	67	33	in	in	ADP
admet-2214	67	34	combination	combination	NOUN
admet-2214	67	35	of	of	ADP
admet-2214	67	36	radiation	radiation	NOUN
admet-2214	67	37	therapy	therapy	NOUN
admet-2214	67	38	and	and	CCONJ
admet-2214	67	39	chemotherapy	chemotherapy	NOUN
admet-2214	67	40	treatment	treatment	NOUN
admet-2214	67	41	roadblocks	roadblock	VERB
admet-2214	67	42	monotherapy	monotherapy	NOUN
admet-2214	67	43	and	and	CCONJ
admet-2214	67	44	combination	combination	NOUN
admet-2214	67	45	chemotherapyno	chemotherapyno	VERB
admet-2214	67	46	substantial	substantial	ADJ
admet-2214	67	47	benefit	benefit	NOUN
admet-2214	67	48	locationdoes	locationdoe	NOUN
admet-2214	67	49	not	not	PART
admet-2214	67	50	allow	allow	VERB
admet-2214	67	51	for	for	ADP
admet-2214	67	52	meaningful	meaningful	ADJ
admet-2214	67	53	surgical	surgical	ADJ
admet-2214	67	54	resection	resection	NOUN
admet-2214	67	55	medication	medication	NOUN
admet-2214	67	56	delivery	delivery	NOUN
admet-2214	67	57	failure	failure	NOUN
admet-2214	67	58	in	in	ADP
admet-2214	67	59	crossing	cross	VERB
admet-2214	67	60	blood	blood	NOUN
admet-2214	67	61	-	-	PUNCT
admet-2214	67	62	brain	brain	NOUN
admet-2214	67	63	barrier	barrier	NOUN
admet-2214	67	64	ongoing	ongoing	ADJ
admet-2214	67	65	trials	trial	NOUN
admet-2214	67	66	histone	histone	PROPN
admet-2214	67	67	deacetylase	deacetylase	PROPN
admet-2214	67	68	(	(	PUNCT
admet-2214	67	69	hdac	hdac	PROPN
admet-2214	67	70	)	)	PUNCT
admet-2214	67	71	and	and	CCONJ
admet-2214	67	72	demethylase	demethylase	VERB
admet-2214	67	73	inhibitors	inhibitor	NOUN
admet-2214	67	74	transcriptional	transcriptional	ADJ
admet-2214	67	75	regulators	regulator	NOUN
admet-2214	67	76	immunotherapy	immunotherapy	NOUN
admet-2214	67	77	immune	immune	ADJ
admet-2214	67	78	cell	cell	NOUN
admet-2214	67	79	recruitment	recruitment	NOUN
admet-2214	67	80	and/or	and/or	CCONJ
admet-2214	67	81	introduction	introduction	NOUN
admet-2214	67	82	to	to	ADP
admet-2214	67	83	tumour	tumour	NOUN
admet-2214	67	84	drug	drug	NOUN
admet-2214	67	85	delivery	delivery	NOUN
admet-2214	67	86	enhancement	enhancement	NOUN
admet-2214	67	87	.	.	PUNCT
admet-2214	68	1	admet	admet	PROPN
admet-2214	68	2	&	&	CCONJ
admet-2214	68	3	dmpk	dmpk	PROPN
admet-2214	68	4	12(3	12(3	PROPN
admet-2214	68	5	)	)	PUNCT
admet-2214	68	6	(	(	PUNCT
admet-2214	68	7	2024	2024	NUM
admet-2214	68	8	)	)	PUNCT
admet-2214	68	9	403	403	NUM
admet-2214	68	10	-	-	SYM
admet-2214	68	11	429	429	NUM
admet-2214	68	12	addressing	address	VERB
admet-2214	68	13	barriers	barrier	NOUN
admet-2214	68	14	in	in	ADP
admet-2214	68	15	diffuse	diffuse	ADJ
admet-2214	68	16	intrinsic	intrinsic	ADJ
admet-2214	68	17	pontine	pontine	ADJ
admet-2214	68	18	glioma	glioma	NOUN
admet-2214	68	19	doi	doi	NOUN
admet-2214	68	20	:	:	PUNCT
admet-2214	68	21	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	68	22	407	407	NUM
admet-2214	68	23	study	study	NOUN
admet-2214	68	24	screening	screen	VERB
admet-2214	68	25	for	for	ADP
admet-2214	68	26	formulations/	formulations/	NUM
admet-2214	68	27	methodology	methodology	NOUN
admet-2214	68	28	in	in	ADP
admet-2214	68	29	order	order	NOUN
admet-2214	68	30	to	to	PART
admet-2214	68	31	complete	complete	VERB
admet-2214	68	32	this	this	DET
admet-2214	68	33	task	task	NOUN
admet-2214	68	34	,	,	PUNCT
admet-2214	68	35	an	an	DET
admet-2214	68	36	extensive	extensive	ADJ
admet-2214	68	37	literature	literature	NOUN
admet-2214	68	38	search	search	NOUN
admet-2214	68	39	was	be	AUX
admet-2214	68	40	conducted	conduct	VERB
admet-2214	68	41	in	in	ADP
admet-2214	68	42	well	well	ADV
admet-2214	68	43	-	-	PUNCT
admet-2214	68	44	established	establish	VERB
admet-2214	68	45	databases	database	NOUN
admet-2214	68	46	such	such	ADJ
admet-2214	68	47	as	as	ADP
admet-2214	68	48	science	science	NOUN
admet-2214	68	49	direct	direct	ADJ
admet-2214	68	50	,	,	PUNCT
admet-2214	68	51	researchgate	researchgate	NOUN
admet-2214	68	52	,	,	PUNCT
admet-2214	68	53	medline	medline	NOUN
admet-2214	68	54	(	(	PUNCT
admet-2214	68	55	pubmed	pubmed	PROPN
admet-2214	68	56	)	)	PUNCT
admet-2214	68	57	,	,	PUNCT
admet-2214	68	58	scopus	scopus	PROPN
admet-2214	68	59	,	,	PUNCT
admet-2214	68	60	taylor	taylor	PROPN
admet-2214	68	61	&	&	CCONJ
admet-2214	68	62	francis	francis	PROPN
admet-2214	68	63	,	,	PUNCT
admet-2214	68	64	and	and	CCONJ
admet-2214	68	65	clinicaltrials.org	clinicaltrials.org	X
admet-2214	68	66	.	.	PUNCT
admet-2214	69	1	the	the	DET
admet-2214	69	2	examination	examination	NOUN
admet-2214	69	3	of	of	ADP
admet-2214	69	4	titles	title	NOUN
admet-2214	69	5	and	and	CCONJ
admet-2214	69	6	abstracts	abstract	NOUN
admet-2214	69	7	of	of	ADP
admet-2214	69	8	published	publish	VERB
admet-2214	69	9	articles	article	NOUN
admet-2214	69	10	,	,	PUNCT
admet-2214	69	11	which	which	PRON
admet-2214	69	12	were	be	AUX
admet-2214	69	13	identified	identify	VERB
admet-2214	69	14	during	during	ADP
admet-2214	69	15	the	the	DET
admet-2214	69	16	search	search	NOUN
admet-2214	69	17	,	,	PUNCT
admet-2214	69	18	was	be	AUX
admet-2214	69	19	conducted	conduct	VERB
admet-2214	69	20	in	in	ADP
admet-2214	69	21	accordance	accordance	NOUN
admet-2214	69	22	with	with	ADP
admet-2214	69	23	the	the	DET
admet-2214	69	24	predetermined	predetermine	VERB
admet-2214	69	25	inclusion	inclusion	NOUN
admet-2214	69	26	and	and	CCONJ
admet-2214	69	27	exclusion	exclusion	NOUN
admet-2214	69	28	criteria	criterion	NOUN
admet-2214	69	29	.	.	PUNCT
admet-2214	70	1	within	within	ADP
admet-2214	70	2	this	this	DET
admet-2214	70	3	context	context	NOUN
admet-2214	70	4	,	,	PUNCT
admet-2214	70	5	this	this	DET
admet-2214	70	6	article	article	NOUN
admet-2214	70	7	presents	present	VERB
admet-2214	70	8	a	a	DET
admet-2214	70	9	thorough	thorough	ADJ
admet-2214	70	10	investigation	investigation	NOUN
admet-2214	70	11	and	and	CCONJ
admet-2214	70	12	analysis	analysis	NOUN
admet-2214	70	13	of	of	ADP
admet-2214	70	14	several	several	ADJ
admet-2214	70	15	formulations	formulation	NOUN
admet-2214	70	16	intended	intend	VERB
admet-2214	70	17	for	for	ADP
admet-2214	70	18	the	the	DET
admet-2214	70	19	treatment	treatment	NOUN
admet-2214	70	20	of	of	ADP
admet-2214	70	21	brain	brain	NOUN
admet-2214	70	22	cancer	cancer	NOUN
admet-2214	70	23	.	.	PUNCT
admet-2214	71	1	to	to	PART
admet-2214	71	2	fully	fully	ADV
admet-2214	71	3	comprehend	comprehend	VERB
admet-2214	71	4	the	the	DET
admet-2214	71	5	various	various	ADJ
admet-2214	71	6	therapy	therapy	NOUN
admet-2214	71	7	modalities	modality	NOUN
admet-2214	71	8	,	,	PUNCT
admet-2214	71	9	a	a	DET
admet-2214	71	10	thorough	thorough	ADJ
admet-2214	71	11	evaluation	evaluation	NOUN
admet-2214	71	12	of	of	ADP
admet-2214	71	13	the	the	DET
admet-2214	71	14	body	body	NOUN
admet-2214	71	15	of	of	ADP
admet-2214	71	16	research	research	NOUN
admet-2214	71	17	,	,	PUNCT
admet-2214	71	18	clinical	clinical	ADJ
admet-2214	71	19	trials	trial	NOUN
admet-2214	71	20	,	,	PUNCT
admet-2214	71	21	and	and	CCONJ
admet-2214	71	22	scholarly	scholarly	ADJ
admet-2214	71	23	articles	article	NOUN
admet-2214	71	24	was	be	AUX
admet-2214	71	25	conducted	conduct	VERB
admet-2214	71	26	.	.	PUNCT
admet-2214	72	1	a	a	DET
admet-2214	72	2	variety	variety	NOUN
admet-2214	72	3	of	of	ADP
admet-2214	72	4	formulations	formulation	NOUN
admet-2214	72	5	,	,	PUNCT
admet-2214	72	6	such	such	ADJ
admet-2214	72	7	as	as	ADP
admet-2214	72	8	immunetherapies	immunetherapie	NOUN
admet-2214	72	9	,	,	PUNCT
admet-2214	72	10	targeted	target	VERB
admet-2214	72	11	therapies	therapy	NOUN
admet-2214	72	12	,	,	PUNCT
admet-2214	72	13	chemotherapeutic	chemotherapeutic	ADJ
admet-2214	72	14	drugs	drug	NOUN
admet-2214	72	15	,	,	PUNCT
admet-2214	72	16	and	and	CCONJ
admet-2214	72	17	combination	combination	NOUN
admet-2214	72	18	medicines	medicine	NOUN
admet-2214	72	19	,	,	PUNCT
admet-2214	72	20	have	have	AUX
admet-2214	72	21	been	be	AUX
admet-2214	72	22	included	include	VERB
admet-2214	72	23	.	.	PUNCT
admet-2214	73	1	the	the	DET
admet-2214	73	2	methods	method	NOUN
admet-2214	73	3	of	of	ADP
admet-2214	73	4	action	action	NOUN
admet-2214	73	5	,	,	PUNCT
admet-2214	73	6	efficacy	efficacy	NOUN
admet-2214	73	7	profiles	profile	NOUN
admet-2214	73	8	,	,	PUNCT
admet-2214	73	9	possible	possible	ADJ
admet-2214	73	10	adverse	adverse	ADJ
admet-2214	73	11	effects	effect	NOUN
admet-2214	73	12	,	,	PUNCT
admet-2214	73	13	and	and	CCONJ
admet-2214	73	14	overall	overall	ADJ
admet-2214	73	15	impact	impact	NOUN
admet-2214	73	16	on	on	ADP
admet-2214	73	17	patient	patient	ADJ
admet-2214	73	18	outcomes	outcome	NOUN
admet-2214	73	19	have	have	AUX
admet-2214	73	20	all	all	PRON
admet-2214	73	21	been	be	AUX
admet-2214	73	22	covered	cover	VERB
admet-2214	73	23	by	by	ADP
admet-2214	73	24	systemic	systemic	ADJ
admet-2214	73	25	analysis	analysis	NOUN
admet-2214	73	26	.	.	PUNCT
admet-2214	74	1	the	the	DET
admet-2214	74	2	outline	outline	NOUN
admet-2214	74	3	of	of	ADP
admet-2214	74	4	our	our	PRON
admet-2214	74	5	screening	screening	NOUN
admet-2214	74	6	using	use	VERB
admet-2214	74	7	different	different	ADJ
admet-2214	74	8	tools	tool	NOUN
admet-2214	74	9	is	be	AUX
admet-2214	74	10	described	describe	VERB
admet-2214	74	11	in	in	ADP
admet-2214	74	12	figure	figure	NOUN
admet-2214	74	13	5	5	NUM
admet-2214	74	14	.	.	PUNCT
admet-2214	74	15	figure	figure	NOUN
admet-2214	74	16	5	5	NUM
admet-2214	74	17	.	.	PUNCT
admet-2214	74	18	pictorial	pictorial	ADJ
admet-2214	74	19	representation	representation	NOUN
admet-2214	74	20	of	of	ADP
admet-2214	74	21	study	study	NOUN
admet-2214	74	22	screening	screen	VERB
admet-2214	74	23	in	in	ADP
admet-2214	74	24	formulations	formulation	NOUN
admet-2214	74	25	available	available	ADJ
admet-2214	74	26	for	for	ADP
admet-2214	74	27	treatment	treatment	NOUN
admet-2214	74	28	of	of	ADP
admet-2214	74	29	dipg	dipg	NOUN
admet-2214	74	30	treatment	treatment	NOUN
admet-2214	74	31	options	option	NOUN
admet-2214	74	32	based	base	VERB
admet-2214	74	33	on	on	ADP
admet-2214	74	34	our	our	PRON
admet-2214	74	35	literature	literature	NOUN
admet-2214	74	36	,	,	PUNCT
admet-2214	74	37	many	many	ADJ
admet-2214	74	38	treatment	treatment	NOUN
admet-2214	74	39	options	option	NOUN
admet-2214	74	40	are	be	AUX
admet-2214	74	41	available	available	ADJ
admet-2214	74	42	for	for	ADP
admet-2214	74	43	dipg	dipg	NOUN
admet-2214	74	44	,	,	PUNCT
admet-2214	74	45	as	as	SCONJ
admet-2214	74	46	shown	show	VERB
admet-2214	74	47	in	in	ADP
admet-2214	74	48	figure	figure	NOUN
admet-2214	74	49	6	6	NUM
admet-2214	74	50	,	,	PUNCT
admet-2214	74	51	and	and	CCONJ
admet-2214	74	52	continuous	continuous	ADJ
admet-2214	74	53	research	research	NOUN
admet-2214	74	54	is	be	AUX
admet-2214	74	55	ongoing	ongoing	ADJ
admet-2214	74	56	to	to	PART
admet-2214	74	57	find	find	VERB
admet-2214	74	58	a	a	DET
admet-2214	74	59	cure	cure	NOUN
admet-2214	74	60	.	.	PUNCT
admet-2214	75	1	conventional	conventional	ADJ
admet-2214	75	2	therapeutic	therapeutic	ADJ
admet-2214	75	3	drugs	drug	NOUN
admet-2214	75	4	are	be	AUX
admet-2214	75	5	limited	limit	VERB
admet-2214	75	6	in	in	ADP
admet-2214	75	7	their	their	PRON
admet-2214	75	8	application	application	NOUN
admet-2214	75	9	due	due	ADP
admet-2214	75	10	to	to	ADP
admet-2214	75	11	their	their	PRON
admet-2214	75	12	non	non	ADJ
admet-2214	75	13	-	-	ADJ
admet-2214	75	14	selectivity	selectivity	ADJ
admet-2214	75	15	,	,	PUNCT
admet-2214	75	16	unfavorable	unfavorable	ADJ
admet-2214	75	17	side	side	NOUN
admet-2214	75	18	effects	effect	NOUN
admet-2214	75	19	,	,	PUNCT
admet-2214	75	20	low	low	ADJ
admet-2214	75	21	efficacy	efficacy	NOUN
admet-2214	75	22	,	,	PUNCT
admet-2214	75	23	and	and	CCONJ
admet-2214	75	24	inadequate	inadequate	ADJ
admet-2214	75	25	biodistribution	biodistribution	NOUN
admet-2214	75	26	.	.	PUNCT
admet-2214	76	1	figure	figure	NOUN
admet-2214	76	2	6	6	NUM
admet-2214	76	3	.	.	PUNCT
admet-2214	76	4	overview	overview	NOUN
admet-2214	76	5	of	of	ADP
admet-2214	76	6	treatment	treatment	NOUN
admet-2214	76	7	options	option	NOUN
admet-2214	76	8	for	for	ADP
admet-2214	76	9	dipg	dipg	NOUN
admet-2214	76	10	.	.	PUNCT
admet-2214	77	1	therefore	therefore	ADV
admet-2214	77	2	,	,	PUNCT
admet-2214	77	3	creating	create	VERB
admet-2214	77	4	delivery	delivery	NOUN
admet-2214	77	5	systems	system	NOUN
admet-2214	77	6	that	that	PRON
admet-2214	77	7	are	be	AUX
admet-2214	77	8	versatile	versatile	ADJ
admet-2214	77	9	and	and	CCONJ
admet-2214	77	10	well	well	ADV
admet-2214	77	11	-	-	PUNCT
admet-2214	77	12	controlled	control	VERB
admet-2214	77	13	is	be	AUX
admet-2214	77	14	the	the	DET
admet-2214	77	15	main	main	ADJ
admet-2214	77	16	goal	goal	NOUN
admet-2214	77	17	of	of	ADP
admet-2214	77	18	current	current	ADJ
admet-2214	77	19	research	research	NOUN
admet-2214	77	20	efforts	effort	NOUN
admet-2214	77	21	[	[	X
admet-2214	77	22	25,26	25,26	X
admet-2214	77	23	]	]	PUNCT
admet-2214	77	24	.	.	PUNCT
admet-2214	78	1	delivering	deliver	VERB
admet-2214	78	2	a	a	DET
admet-2214	78	3	variety	variety	NOUN
admet-2214	78	4	of	of	ADP
admet-2214	78	5	compounds	compound	NOUN
admet-2214	78	6	to	to	ADP
admet-2214	78	7	specific	specific	ADJ
admet-2214	78	8	parts	part	NOUN
admet-2214	78	9	of	of	ADP
admet-2214	78	10	the	the	DET
admet-2214	78	11	body	body	NOUN
admet-2214	78	12	through	through	ADP
admet-2214	78	13	the	the	DET
admet-2214	78	14	association	association	NOUN
admet-2214	78	15	of	of	ADP
admet-2214	78	16	therapeutic	therapeutic	ADJ
admet-2214	78	17	medicines	medicine	NOUN
admet-2214	78	18	with	with	ADP
admet-2214	78	19	nanoparticles	nanoparticle	NOUN
admet-2214	78	20	that	that	PRON
admet-2214	78	21	have	have	VERB
admet-2214	78	22	distinctive	distinctive	ADJ
admet-2214	78	23	physicochemical	physicochemical	ADJ
admet-2214	78	24	and	and	CCONJ
admet-2214	78	25	biological	biological	ADJ
admet-2214	78	26	properties	property	NOUN
admet-2214	78	27	and	and	CCONJ
admet-2214	78	28	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	78	29	z.	z.	PROPN
admet-2214	78	30	presswala	presswala	PROPN
admet-2214	78	31	et	et	PROPN
admet-2214	78	32	al	al	PROPN
admet-2214	78	33	.	.	PROPN
admet-2214	78	34	admet	admet	PROPN
admet-2214	78	35	&	&	CCONJ
admet-2214	78	36	dmpk	dmpk	PROPN
admet-2214	78	37	12(3	12(3	PROPN
admet-2214	78	38	)	)	PUNCT
admet-2214	78	39	(	(	PUNCT
admet-2214	78	40	2024	2024	NUM
admet-2214	78	41	)	)	PUNCT
admet-2214	78	42	403	403	NUM
admet-2214	78	43	-	-	SYM
admet-2214	78	44	429	429	NUM
admet-2214	78	45	408	408	NUM
admet-2214	78	46	engineering	engineer	VERB
admet-2214	78	47	their	their	PRON
admet-2214	78	48	paths	path	NOUN
admet-2214	78	49	for	for	ADP
admet-2214	78	50	appropriate	appropriate	ADJ
admet-2214	78	51	targeting	targeting	NOUN
admet-2214	78	52	is	be	AUX
admet-2214	78	53	a	a	DET
admet-2214	78	54	promising	promising	ADJ
admet-2214	78	55	strategy	strategy	NOUN
admet-2214	78	56	[	[	X
admet-2214	78	57	25,27	25,27	NUM
admet-2214	78	58	]	]	PUNCT
admet-2214	78	59	.	.	PUNCT
admet-2214	79	1	the	the	DET
admet-2214	79	2	utilization	utilization	NOUN
admet-2214	79	3	of	of	ADP
admet-2214	79	4	carriers	carrier	NOUN
admet-2214	79	5	in	in	ADP
admet-2214	79	6	protecting	protect	VERB
admet-2214	79	7	sensitive	sensitive	ADJ
admet-2214	79	8	drugs	drug	NOUN
admet-2214	79	9	from	from	ADP
admet-2214	79	10	enzymatic	enzymatic	ADJ
admet-2214	79	11	degradation	degradation	NOUN
admet-2214	79	12	and	and	CCONJ
admet-2214	79	13	the	the	DET
admet-2214	79	14	subsequent	subsequent	ADJ
admet-2214	79	15	enhancement	enhancement	NOUN
admet-2214	79	16	of	of	ADP
admet-2214	79	17	drug	drug	NOUN
admet-2214	79	18	bioavailability	bioavailability	NOUN
admet-2214	79	19	by	by	ADP
admet-2214	79	20	promoting	promote	VERB
admet-2214	79	21	their	their	PRON
admet-2214	79	22	diffusion	diffusion	NOUN
admet-2214	79	23	through	through	ADP
admet-2214	79	24	biological	biological	ADJ
admet-2214	79	25	membranes	membrane	NOUN
admet-2214	79	26	is	be	AUX
admet-2214	79	27	a	a	DET
admet-2214	79	28	significant	significant	ADJ
admet-2214	79	29	area	area	NOUN
admet-2214	79	30	of	of	ADP
admet-2214	79	31	research	research	NOUN
admet-2214	79	32	.	.	PUNCT
admet-2214	80	1	a	a	DET
admet-2214	80	2	developing	develop	VERB
admet-2214	80	3	method	method	NOUN
admet-2214	80	4	for	for	ADP
admet-2214	80	5	using	use	VERB
admet-2214	80	6	nanotechnological	nanotechnological	ADJ
admet-2214	80	7	systems	system	NOUN
admet-2214	80	8	in	in	ADP
admet-2214	80	9	illness	illness	NOUN
admet-2214	80	10	diagnosis	diagnosis	NOUN
admet-2214	80	11	and	and	CCONJ
admet-2214	80	12	treatment	treatment	NOUN
admet-2214	80	13	is	be	AUX
admet-2214	80	14	called	call	VERB
admet-2214	80	15	nanomedicine	nanomedicine	ADJ
admet-2214	80	16	.	.	PUNCT
admet-2214	80	17	nanomaterials	nanomaterial	NOUN
admet-2214	80	18	and	and	CCONJ
admet-2214	80	19	nanodevices	nanodevice	NOUN
admet-2214	80	20	are	be	AUX
admet-2214	80	21	the	the	DET
admet-2214	80	22	two	two	NUM
admet-2214	80	23	primary	primary	ADJ
admet-2214	80	24	categories	category	NOUN
admet-2214	80	25	into	into	ADP
admet-2214	80	26	which	which	PRON
admet-2214	80	27	this	this	DET
admet-2214	80	28	area	area	NOUN
admet-2214	80	29	of	of	ADP
admet-2214	80	30	nanotechnology	nanotechnology	NOUN
admet-2214	80	31	can	can	AUX
admet-2214	80	32	be	be	AUX
admet-2214	80	33	divided	divide	VERB
admet-2214	80	34	.	.	PUNCT
admet-2214	81	1	nanodevices	nanodevice	NOUN
admet-2214	81	2	are	be	AUX
admet-2214	81	3	tiny	tiny	ADJ
admet-2214	81	4	,	,	PUNCT
admet-2214	81	5	nanoscale	nanoscale	NOUN
admet-2214	81	6	devices	device	NOUN
admet-2214	81	7	,	,	PUNCT
admet-2214	81	8	such	such	ADJ
admet-2214	81	9	as	as	ADP
admet-2214	81	10	respirocytes	respirocyte	NOUN
admet-2214	81	11	and	and	CCONJ
admet-2214	81	12	microarrays	microarray	NOUN
admet-2214	81	13	,	,	PUNCT
admet-2214	81	14	capable	capable	ADJ
admet-2214	81	15	of	of	ADP
admet-2214	81	16	intelligence	intelligence	NOUN
admet-2214	81	17	.	.	PUNCT
admet-2214	82	1	particles	particle	NOUN
admet-2214	82	2	smaller	small	ADJ
admet-2214	82	3	than	than	ADP
admet-2214	82	4	100	100	NUM
admet-2214	82	5	nm	nm	NOUN
admet-2214	82	6	in	in	ADP
admet-2214	82	7	at	at	ADV
admet-2214	82	8	least	least	ADV
admet-2214	82	9	one	one	NUM
admet-2214	82	10	dimension	dimension	NOUN
admet-2214	82	11	are	be	AUX
admet-2214	82	12	found	find	VERB
admet-2214	82	13	in	in	ADP
admet-2214	82	14	nanomaterials	nanomaterial	NOUN
admet-2214	82	15	[	[	X
admet-2214	82	16	28	28	NUM
admet-2214	82	17	-	-	SYM
admet-2214	82	18	30	30	NUM
admet-2214	82	19	]	]	PUNCT
admet-2214	82	20	.	.	PUNCT
admet-2214	83	1	figure	figure	NOUN
admet-2214	83	2	7	7	NUM
admet-2214	83	3	describes	describe	VERB
admet-2214	83	4	different	different	ADJ
admet-2214	83	5	classes	class	NOUN
admet-2214	83	6	of	of	ADP
admet-2214	83	7	nanoparticles	nanoparticle	NOUN
admet-2214	83	8	.	.	PUNCT
admet-2214	84	1	figure	figure	VERB
admet-2214	84	2	7	7	NUM
admet-2214	84	3	.	.	PUNCT
admet-2214	84	4	classification	classification	NOUN
admet-2214	84	5	of	of	ADP
admet-2214	84	6	nanoparticles	nanoparticle	NOUN
admet-2214	84	7	how	how	SCONJ
admet-2214	84	8	nanoparticles	nanoparticle	NOUN
admet-2214	84	9	can	can	AUX
admet-2214	84	10	cross	cross	VERB
admet-2214	84	11	the	the	DET
admet-2214	84	12	blood	blood	NOUN
admet-2214	84	13	-	-	PUNCT
admet-2214	84	14	brain	brain	NOUN
admet-2214	84	15	barrier	barrier	NOUN
admet-2214	84	16	nanoparticles	nanoparticle	NOUN
admet-2214	84	17	(	(	PUNCT
admet-2214	84	18	np	np	X
admet-2214	84	19	)	)	PUNCT
admet-2214	84	20	are	be	AUX
admet-2214	84	21	suitable	suitable	ADJ
admet-2214	84	22	carriers	carrier	NOUN
admet-2214	84	23	for	for	ADP
admet-2214	84	24	drug	drug	NOUN
admet-2214	84	25	delivery	delivery	NOUN
admet-2214	84	26	to	to	ADP
admet-2214	84	27	brain	brain	NOUN
admet-2214	84	28	tissues	tissue	NOUN
admet-2214	84	29	as	as	SCONJ
admet-2214	84	30	they	they	PRON
admet-2214	84	31	can	can	AUX
admet-2214	84	32	enhance	enhance	VERB
admet-2214	84	33	drug	drug	NOUN
admet-2214	84	34	permeation	permeation	NOUN
admet-2214	84	35	through	through	ADP
admet-2214	84	36	the	the	DET
admet-2214	84	37	blood	blood	NOUN
admet-2214	84	38	-	-	PUNCT
admet-2214	84	39	brain	brain	NOUN
admet-2214	84	40	barrier	barrier	NOUN
admet-2214	84	41	(	(	PUNCT
admet-2214	84	42	bbb	bbb	NOUN
admet-2214	84	43	)	)	PUNCT
admet-2214	84	44	by	by	ADP
admet-2214	84	45	both	both	CCONJ
admet-2214	84	46	active	active	ADJ
admet-2214	84	47	(	(	PUNCT
admet-2214	84	48	through	through	ADP
admet-2214	84	49	receptor	receptor	NOUN
admet-2214	84	50	and	and	CCONJ
admet-2214	84	51	carrier	carrier	NOUN
admet-2214	84	52	transport	transport	NOUN
admet-2214	84	53	)	)	PUNCT
admet-2214	84	54	and	and	CCONJ
admet-2214	84	55	passive	passive	ADJ
admet-2214	84	56	diffusion	diffusion	NOUN
admet-2214	84	57	(	(	PUNCT
admet-2214	84	58	through	through	ADP
admet-2214	84	59	paracellular	paracellular	ADJ
admet-2214	84	60	and	and	CCONJ
admet-2214	84	61	transcellular	transcellular	NOUN
admet-2214	84	62	pathways	pathway	NOUN
admet-2214	84	63	)	)	PUNCT
admet-2214	84	64	.	.	PUNCT
admet-2214	85	1	figure	figure	NOUN
admet-2214	85	2	8	8	NUM
admet-2214	85	3	shows	show	VERB
admet-2214	85	4	various	various	ADJ
admet-2214	85	5	pathways	pathway	NOUN
admet-2214	85	6	for	for	SCONJ
admet-2214	85	7	np	np	NOUN
admet-2214	85	8	to	to	PART
admet-2214	85	9	enter	enter	VERB
admet-2214	85	10	the	the	DET
admet-2214	85	11	brain	brain	NOUN
admet-2214	86	1	[	[	X
admet-2214	86	2	31	31	NUM
admet-2214	86	3	]	]	PUNCT
admet-2214	86	4	.	.	PUNCT
admet-2214	87	1	figure	figure	NOUN
admet-2214	87	2	8	8	NUM
admet-2214	87	3	.	.	PUNCT
admet-2214	88	1	different	different	ADJ
admet-2214	88	2	mechanisms	mechanism	NOUN
admet-2214	88	3	of	of	ADP
admet-2214	88	4	drug	drug	NOUN
admet-2214	88	5	crossing	crossing	NOUN
admet-2214	88	6	from	from	ADP
admet-2214	88	7	blood	blood	NOUN
admet-2214	88	8	into	into	ADP
admet-2214	88	9	the	the	DET
admet-2214	88	10	brain	brain	NOUN
admet-2214	88	11	admet	admet	PROPN
admet-2214	88	12	&	&	CCONJ
admet-2214	88	13	dmpk	dmpk	PROPN
admet-2214	88	14	12(3	12(3	PROPN
admet-2214	88	15	)	)	PUNCT
admet-2214	88	16	(	(	PUNCT
admet-2214	88	17	2024	2024	NUM
admet-2214	88	18	)	)	PUNCT
admet-2214	88	19	403	403	NUM
admet-2214	88	20	-	-	SYM
admet-2214	88	21	429	429	NUM
admet-2214	88	22	addressing	address	VERB
admet-2214	88	23	barriers	barrier	NOUN
admet-2214	88	24	in	in	ADP
admet-2214	88	25	diffuse	diffuse	ADJ
admet-2214	88	26	intrinsic	intrinsic	ADJ
admet-2214	88	27	pontine	pontine	ADJ
admet-2214	88	28	glioma	glioma	NOUN
admet-2214	88	29	doi	doi	NOUN
admet-2214	88	30	:	:	PUNCT
admet-2214	88	31	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	88	32	409	409	NUM
admet-2214	88	33	role	role	NOUN
admet-2214	88	34	of	of	ADP
admet-2214	88	35	size	size	NOUN
admet-2214	88	36	,	,	PUNCT
admet-2214	88	37	surface	surface	NOUN
admet-2214	88	38	charge	charge	NOUN
admet-2214	88	39	and	and	CCONJ
admet-2214	88	40	ligands	ligand	NOUN
admet-2214	88	41	of	of	ADP
admet-2214	88	42	nanoparticles	nanoparticle	NOUN
admet-2214	88	43	influencing	influence	VERB
admet-2214	88	44	bbb	bbb	PROPN
admet-2214	88	45	permeation	permeation	NOUN
admet-2214	88	46	several	several	ADJ
admet-2214	88	47	aspects	aspect	NOUN
admet-2214	88	48	influence	influence	VERB
admet-2214	88	49	the	the	DET
admet-2214	88	50	effectiveness	effectiveness	NOUN
admet-2214	88	51	of	of	ADP
admet-2214	88	52	np	np	INTJ
admet-2214	88	53	systemic	systemic	ADJ
admet-2214	88	54	circulation	circulation	NOUN
admet-2214	88	55	,	,	PUNCT
admet-2214	88	56	bbb	bbb	NOUN
admet-2214	88	57	penetration	penetration	NOUN
admet-2214	88	58	,	,	PUNCT
admet-2214	88	59	and	and	CCONJ
admet-2214	88	60	cellular	cellular	ADJ
admet-2214	88	61	delivery	delivery	NOUN
admet-2214	88	62	.	.	PUNCT
admet-2214	89	1	these	these	DET
admet-2214	89	2	aspects	aspect	NOUN
admet-2214	89	3	have	have	AUX
admet-2214	89	4	been	be	AUX
admet-2214	89	5	outlined	outline	VERB
admet-2214	89	6	in	in	ADP
admet-2214	89	7	figure	figure	NOUN
admet-2214	89	8	9	9	NUM
admet-2214	89	9	.	.	PUNCT
admet-2214	90	1	multiple	multiple	ADJ
admet-2214	90	2	studies	study	NOUN
admet-2214	90	3	have	have	AUX
admet-2214	90	4	demonstrated	demonstrate	VERB
admet-2214	90	5	a	a	DET
admet-2214	90	6	distinct	distinct	ADJ
admet-2214	90	7	negative	negative	ADJ
admet-2214	90	8	link	link	NOUN
admet-2214	90	9	between	between	ADP
admet-2214	90	10	the	the	DET
admet-2214	90	11	size	size	NOUN
admet-2214	90	12	of	of	ADP
admet-2214	90	13	nanoparticles	nanoparticle	NOUN
admet-2214	90	14	(	(	PUNCT
admet-2214	90	15	nps	nps	PROPN
admet-2214	90	16	)	)	PUNCT
admet-2214	90	17	and	and	CCONJ
admet-2214	90	18	their	their	PRON
admet-2214	90	19	ability	ability	NOUN
admet-2214	90	20	to	to	PART
admet-2214	90	21	penetrate	penetrate	VERB
admet-2214	90	22	the	the	DET
admet-2214	90	23	blood	blood	NOUN
admet-2214	90	24	-	-	PUNCT
admet-2214	90	25	brain	brain	NOUN
admet-2214	90	26	barrier	barrier	NOUN
admet-2214	90	27	(	(	PUNCT
admet-2214	90	28	bbb	bbb	NOUN
admet-2214	90	29	)	)	PUNCT
admet-2214	91	1	[	[	X
admet-2214	91	2	32	32	NUM
admet-2214	91	3	-	-	SYM
admet-2214	91	4	35	35	NUM
admet-2214	91	5	]	]	PUNCT
admet-2214	91	6	.	.	PUNCT
admet-2214	92	1	np	np	INTJ
admet-2214	92	2	can	can	AUX
admet-2214	92	3	be	be	AUX
admet-2214	92	4	anywhere	anywhere	ADV
admet-2214	92	5	between	between	ADP
admet-2214	92	6	1	1	NUM
admet-2214	92	7	and	and	CCONJ
admet-2214	92	8	1000	1000	NUM
admet-2214	92	9	nm	nm	NOUN
admet-2214	92	10	in	in	ADP
admet-2214	92	11	size	size	NOUN
admet-2214	92	12	,	,	PUNCT
admet-2214	92	13	and	and	CCONJ
admet-2214	92	14	they	they	PRON
admet-2214	92	15	can	can	AUX
admet-2214	92	16	entrap	entrap	VERB
admet-2214	92	17	,	,	PUNCT
admet-2214	92	18	adsorb	adsorb	VERB
admet-2214	92	19	,	,	PUNCT
admet-2214	92	20	or	or	CCONJ
admet-2214	92	21	covalently	covalently	ADV
admet-2214	92	22	bind	bind	VERB
admet-2214	92	23	drugs	drug	NOUN
admet-2214	92	24	to	to	ADP
admet-2214	92	25	cells	cell	NOUN
admet-2214	92	26	.	.	PUNCT
admet-2214	93	1	zeta	zeta	PROPN
admet-2214	93	2	potential	potential	NOUN
admet-2214	93	3	is	be	AUX
admet-2214	93	4	a	a	DET
admet-2214	93	5	significant	significant	ADJ
admet-2214	93	6	factor	factor	NOUN
admet-2214	93	7	that	that	PRON
admet-2214	93	8	influences	influence	VERB
admet-2214	93	9	the	the	DET
admet-2214	93	10	movement	movement	NOUN
admet-2214	93	11	of	of	ADP
admet-2214	93	12	nanoparticles	nanoparticle	NOUN
admet-2214	93	13	through	through	ADP
admet-2214	93	14	the	the	DET
admet-2214	93	15	bloodbrain	bloodbrain	NOUN
admet-2214	93	16	barrier	barrier	NOUN
admet-2214	93	17	(	(	PUNCT
admet-2214	93	18	bbb	bbb	PROPN
admet-2214	93	19	)	)	PUNCT
admet-2214	93	20	.	.	PUNCT
admet-2214	94	1	research	research	NOUN
admet-2214	94	2	has	have	AUX
admet-2214	94	3	demonstrated	demonstrate	VERB
admet-2214	94	4	that	that	SCONJ
admet-2214	94	5	nanoparticles	nanoparticle	NOUN
admet-2214	94	6	(	(	PUNCT
admet-2214	94	7	nps	nps	PROPN
admet-2214	94	8	)	)	PUNCT
admet-2214	94	9	possessing	possess	VERB
admet-2214	94	10	a	a	DET
admet-2214	94	11	high	high	ADJ
admet-2214	94	12	zeta	zeta	NOUN
admet-2214	94	13	potential	potential	NOUN
admet-2214	94	14	(	(	PUNCT
admet-2214	94	15	indicating	indicate	VERB
admet-2214	94	16	a	a	DET
admet-2214	94	17	strong	strong	ADJ
admet-2214	94	18	positive	positive	ADJ
admet-2214	94	19	charge	charge	NOUN
admet-2214	94	20	)	)	PUNCT
admet-2214	94	21	induce	induce	VERB
admet-2214	94	22	rapid	rapid	ADJ
admet-2214	94	23	toxicity	toxicity	NOUN
admet-2214	94	24	at	at	ADP
admet-2214	94	25	the	the	DET
admet-2214	94	26	blood	blood	NOUN
admet-2214	94	27	-	-	PUNCT
admet-2214	94	28	brain	brain	NOUN
admet-2214	94	29	barrier	barrier	NOUN
admet-2214	94	30	(	(	PUNCT
admet-2214	94	31	bbb	bbb	NOUN
admet-2214	94	32	)	)	PUNCT
admet-2214	95	1	[	[	X
admet-2214	95	2	32,36	32,36	NUM
admet-2214	95	3	]	]	PUNCT
admet-2214	95	4	.	.	PUNCT
admet-2214	96	1	thus	thus	ADV
admet-2214	96	2	,	,	PUNCT
admet-2214	96	3	most	most	ADJ
admet-2214	96	4	np	np	ADP
admet-2214	96	5	formulations	formulation	NOUN
admet-2214	96	6	discussed	discuss	VERB
admet-2214	96	7	in	in	ADP
admet-2214	96	8	the	the	DET
admet-2214	96	9	literature	literature	NOUN
admet-2214	96	10	regarding	regard	VERB
admet-2214	96	11	brain	brain	NOUN
admet-2214	96	12	administration	administration	NOUN
admet-2214	96	13	have	have	VERB
admet-2214	96	14	a	a	DET
admet-2214	96	15	moderate	moderate	ADJ
admet-2214	96	16	charge	charge	NOUN
admet-2214	96	17	ranging	range	VERB
admet-2214	96	18	from	from	ADP
admet-2214	96	19	-1	-1	ADV
admet-2214	96	20	to	to	ADP
admet-2214	96	21	-15	-15	PUNCT
admet-2214	96	22	mv	mv	PROPN
admet-2214	96	23	or	or	CCONJ
admet-2214	96	24	high	high	ADJ
admet-2214	96	25	(	(	PUNCT
admet-2214	96	26	between	between	ADP
admet-2214	96	27	-15	-15	PUNCT
admet-2214	96	28	and	and	CCONJ
admet-2214	96	29	-45	-45	PUNCT
admet-2214	96	30	mv	mv	PROPN
admet-2214	96	31	)	)	PUNCT
admet-2214	97	1	[	[	X
admet-2214	97	2	37,38	37,38	NOUN
admet-2214	97	3	]	]	PUNCT
admet-2214	97	4	.	.	PUNCT
admet-2214	98	1	figure	figure	NOUN
admet-2214	98	2	9	9	NUM
admet-2214	98	3	.	.	PUNCT
admet-2214	98	4	main	main	ADJ
admet-2214	98	5	nanoparticle	nanoparticle	NOUN
admet-2214	98	6	(	(	PUNCT
admet-2214	98	7	np	np	INTJ
admet-2214	98	8	)	)	PUNCT
admet-2214	98	9	features	feature	VERB
admet-2214	98	10	influencing	influence	VERB
admet-2214	98	11	systemic	systemic	ADJ
admet-2214	98	12	delivery	delivery	NOUN
admet-2214	98	13	and	and	CCONJ
admet-2214	98	14	blood	blood	NOUN
admet-2214	98	15	-	-	PUNCT
admet-2214	98	16	brain	brain	NOUN
admet-2214	98	17	barrier	barrier	NOUN
admet-2214	98	18	(	(	PUNCT
admet-2214	98	19	bbb	bbb	NOUN
admet-2214	98	20	)	)	PUNCT
admet-2214	98	21	passage	passage	NOUN
admet-2214	98	22	ligand	ligand	NOUN
admet-2214	98	23	targeting	target	VERB
admet-2214	98	24	is	be	AUX
admet-2214	98	25	the	the	DET
admet-2214	98	26	process	process	NOUN
admet-2214	98	27	of	of	ADP
admet-2214	98	28	adding	add	VERB
admet-2214	98	29	particular	particular	ADJ
admet-2214	98	30	ligands	ligand	NOUN
admet-2214	98	31	to	to	ADP
admet-2214	98	32	the	the	DET
admet-2214	98	33	surface	surface	NOUN
admet-2214	98	34	of	of	ADP
admet-2214	98	35	nms	nms	NOUN
admet-2214	98	36	to	to	PART
admet-2214	98	37	enable	enable	VERB
admet-2214	98	38	better	well	ADJ
admet-2214	98	39	interaction	interaction	NOUN
admet-2214	98	40	with	with	ADP
admet-2214	98	41	bbb	bbb	NOUN
admet-2214	98	42	receptors	receptor	NOUN
admet-2214	98	43	or	or	CCONJ
admet-2214	98	44	transporters	transporter	NOUN
admet-2214	98	45	[	[	X
admet-2214	98	46	39	39	NUM
admet-2214	98	47	]	]	PUNCT
admet-2214	98	48	.	.	PUNCT
admet-2214	99	1	several	several	ADJ
admet-2214	99	2	ligands	ligand	NOUN
admet-2214	99	3	have	have	AUX
admet-2214	99	4	been	be	AUX
admet-2214	99	5	attached	attach	VERB
admet-2214	99	6	to	to	ADP
admet-2214	99	7	nanoparticles	nanoparticle	NOUN
admet-2214	99	8	(	(	PUNCT
admet-2214	99	9	nps	nps	PROPN
admet-2214	99	10	)	)	PUNCT
admet-2214	99	11	to	to	PART
admet-2214	99	12	enhance	enhance	VERB
admet-2214	99	13	their	their	PRON
admet-2214	99	14	ability	ability	NOUN
admet-2214	99	15	to	to	PART
admet-2214	99	16	cross	cross	VERB
admet-2214	99	17	the	the	DET
admet-2214	99	18	blood	blood	NOUN
admet-2214	99	19	-	-	PUNCT
admet-2214	99	20	brain	brain	NOUN
admet-2214	99	21	barrier	barrier	NOUN
admet-2214	99	22	(	(	PUNCT
admet-2214	99	23	bbb	bbb	PROPN
admet-2214	99	24	)	)	PUNCT
admet-2214	99	25	.	.	PUNCT
admet-2214	100	1	these	these	DET
admet-2214	100	2	molecules	molecule	NOUN
admet-2214	100	3	can	can	AUX
admet-2214	100	4	be	be	AUX
admet-2214	100	5	classified	classify	VERB
admet-2214	100	6	into	into	ADP
admet-2214	100	7	four	four	NUM
admet-2214	100	8	distinct	distinct	ADJ
admet-2214	100	9	categories	category	NOUN
admet-2214	100	10	:	:	PUNCT
admet-2214	100	11	(	(	PUNCT
admet-2214	100	12	i	i	NOUN
admet-2214	100	13	)	)	PUNCT
admet-2214	100	14	ligands	ligand	NOUN
admet-2214	100	15	that	that	PRON
admet-2214	100	16	facilitate	facilitate	VERB
admet-2214	100	17	the	the	DET
admet-2214	100	18	binding	binding	NOUN
admet-2214	100	19	of	of	ADP
admet-2214	100	20	proteins	protein	NOUN
admet-2214	100	21	from	from	ADP
admet-2214	100	22	the	the	DET
admet-2214	100	23	bloodstream	bloodstream	NOUN
admet-2214	100	24	to	to	ADP
admet-2214	100	25	specific	specific	ADJ
admet-2214	100	26	receptors	receptor	NOUN
admet-2214	100	27	or	or	CCONJ
admet-2214	100	28	transporters	transporter	NOUN
admet-2214	100	29	in	in	ADP
admet-2214	100	30	the	the	DET
admet-2214	100	31	blood	blood	NOUN
admet-2214	100	32	-	-	PUNCT
admet-2214	100	33	brain	brain	NOUN
admet-2214	100	34	barrier	barrier	NOUN
admet-2214	100	35	(	(	PUNCT
admet-2214	100	36	bbb	bbb	PROPN
admet-2214	100	37	)	)	PUNCT
admet-2214	100	38	;	;	PUNCT
admet-2214	100	39	(	(	PUNCT
admet-2214	100	40	ii	ii	NOUN
admet-2214	100	41	)	)	PUNCT
admet-2214	100	42	ligands	ligand	NOUN
admet-2214	100	43	that	that	PRON
admet-2214	100	44	directly	directly	ADV
admet-2214	100	45	interact	interact	VERB
admet-2214	100	46	with	with	ADP
admet-2214	100	47	bbb	bbb	NOUN
admet-2214	100	48	receptors	receptor	NOUN
admet-2214	100	49	or	or	CCONJ
admet-2214	100	50	transporters	transporter	NOUN
admet-2214	100	51	;	;	PUNCT
admet-2214	100	52	(	(	PUNCT
admet-2214	100	53	iii	iii	X
admet-2214	100	54	)	)	PUNCT
admet-2214	100	55	ligands	ligand	NOUN
admet-2214	100	56	that	that	PRON
admet-2214	100	57	enhance	enhance	VERB
admet-2214	100	58	the	the	DET
admet-2214	100	59	electrical	electrical	ADJ
admet-2214	100	60	charge	charge	NOUN
admet-2214	100	61	and	and	CCONJ
admet-2214	100	62	hydrophobic	hydrophobic	NOUN
admet-2214	100	63	properties	property	NOUN
admet-2214	100	64	and	and	CCONJ
admet-2214	100	65	(	(	PUNCT
admet-2214	100	66	iv	iv	X
admet-2214	100	67	)	)	PUNCT
admet-2214	100	68	ligands	ligand	NOUN
admet-2214	100	69	that	that	PRON
admet-2214	100	70	enhance	enhance	VERB
admet-2214	100	71	the	the	DET
admet-2214	100	72	duration	duration	NOUN
admet-2214	100	73	of	of	ADP
admet-2214	100	74	blood	blood	NOUN
admet-2214	100	75	circulation	circulation	NOUN
admet-2214	101	1	[	[	X
admet-2214	101	2	32,40,41	32,40,41	NUM
admet-2214	101	3	]	]	PUNCT
admet-2214	101	4	.	.	PUNCT
admet-2214	102	1	in	in	ADP
admet-2214	102	2	the	the	DET
admet-2214	102	3	first	first	ADJ
admet-2214	102	4	scenario	scenario	NOUN
admet-2214	102	5	,	,	PUNCT
admet-2214	102	6	we	we	PRON
admet-2214	102	7	can	can	AUX
admet-2214	102	8	incorporate	incorporate	VERB
admet-2214	102	9	poly(sorbate	poly(sorbate	NOUN
admet-2214	102	10	80	80	NUM
admet-2214	102	11	)	)	PUNCT
admet-2214	102	12	(	(	PUNCT
admet-2214	102	13	often	often	ADV
admet-2214	102	14	referred	refer	VERB
admet-2214	102	15	to	to	ADP
admet-2214	102	16	as	as	ADP
admet-2214	102	17	tween	tween	NOUN
admet-2214	102	18	80	80	NUM
admet-2214	102	19	)	)	PUNCT
admet-2214	102	20	,	,	PUNCT
admet-2214	102	21	which	which	PRON
admet-2214	102	22	has	have	VERB
admet-2214	102	23	the	the	DET
admet-2214	102	24	ability	ability	NOUN
admet-2214	102	25	to	to	PART
admet-2214	102	26	adsorb	adsorb	VERB
admet-2214	102	27	apolipoprotein	apolipoprotein	ADJ
admet-2214	102	28	e	e	PROPN
admet-2214	102	29	and/or	and/or	CCONJ
admet-2214	102	30	a	a	DET
admet-2214	102	31	-	-	PUNCT
admet-2214	102	32	i.	i.	NOUN
admet-2214	102	33	the	the	DET
admet-2214	102	34	surfactant	surfactant	NOUN
admet-2214	102	35	facilitates	facilitate	VERB
admet-2214	102	36	the	the	DET
admet-2214	102	37	attachment	attachment	NOUN
admet-2214	102	38	of	of	ADP
admet-2214	102	39	apolipoproteins	apolipoprotein	NOUN
admet-2214	102	40	,	,	PUNCT
admet-2214	102	41	which	which	PRON
admet-2214	102	42	then	then	ADV
admet-2214	102	43	engage	engage	VERB
admet-2214	102	44	with	with	ADP
admet-2214	102	45	lipoprotein	lipoprotein	ADJ
admet-2214	102	46	receptors	receptor	NOUN
admet-2214	102	47	in	in	ADP
admet-2214	102	48	the	the	DET
admet-2214	102	49	brain	brain	NOUN
admet-2214	102	50	endothelium	endothelium	NOUN
admet-2214	102	51	,	,	PUNCT
admet-2214	102	52	allowing	allow	VERB
admet-2214	102	53	passage	passage	NOUN
admet-2214	102	54	through	through	ADP
admet-2214	102	55	the	the	DET
admet-2214	102	56	bloodbrain	bloodbrain	NOUN
admet-2214	102	57	barrier	barrier	NOUN
admet-2214	102	58	(	(	PUNCT
admet-2214	102	59	bbb	bbb	NOUN
admet-2214	102	60	)	)	PUNCT
admet-2214	102	61	.	.	PUNCT
admet-2214	103	1	in	in	ADP
admet-2214	103	2	the	the	DET
admet-2214	103	3	second	second	ADJ
admet-2214	103	4	scenario	scenario	NOUN
admet-2214	103	5	,	,	PUNCT
admet-2214	103	6	we	we	PRON
admet-2214	103	7	have	have	VERB
admet-2214	103	8	the	the	DET
admet-2214	103	9	option	option	NOUN
admet-2214	103	10	to	to	PART
admet-2214	103	11	incorporate	incorporate	VERB
admet-2214	103	12	multiple	multiple	ADJ
admet-2214	103	13	targeting	target	VERB
admet-2214	103	14	ligands	ligand	NOUN
admet-2214	103	15	,	,	PUNCT
admet-2214	103	16	such	such	ADJ
admet-2214	103	17	as	as	ADP
admet-2214	103	18	those	those	PRON
admet-2214	103	19	designed	design	VERB
admet-2214	103	20	for	for	ADP
admet-2214	103	21	the	the	DET
admet-2214	103	22	transferrin	transferrin	NOUN
admet-2214	103	23	receptor	receptor	NOUN
admet-2214	103	24	(	(	PUNCT
admet-2214	103	25	transferrin	transferrin	NOUN
admet-2214	103	26	peptide	peptide	NOUN
admet-2214	103	27	,	,	PUNCT
admet-2214	103	28	transferrin	transferrin	NOUN
admet-2214	103	29	protein	protein	NOUN
admet-2214	103	30	,	,	PUNCT
admet-2214	103	31	or	or	CCONJ
admet-2214	103	32	antibody	antibody	NOUN
admet-2214	103	33	against	against	ADP
admet-2214	103	34	transferrin	transferrin	NOUN
admet-2214	103	35	)	)	PUNCT
admet-2214	103	36	,	,	PUNCT
admet-2214	103	37	insulin	insulin	NOUN
admet-2214	103	38	receptor	receptor	NOUN
admet-2214	103	39	,	,	PUNCT
admet-2214	103	40	glucose	glucose	NOUN
admet-2214	103	41	transporter	transporter	NOUN
admet-2214	103	42	,	,	PUNCT
admet-2214	103	43	and	and	CCONJ
admet-2214	103	44	various	various	ADJ
admet-2214	103	45	others	other	NOUN
admet-2214	103	46	[	[	X
admet-2214	103	47	40,42,43	40,42,43	NOUN
admet-2214	103	48	]	]	PUNCT
admet-2214	103	49	.	.	PUNCT
admet-2214	104	1	in	in	ADP
admet-2214	104	2	the	the	DET
admet-2214	104	3	third	third	ADJ
admet-2214	104	4	scenario	scenario	NOUN
admet-2214	104	5	,	,	PUNCT
admet-2214	104	6	nanoparticles	nanoparticle	NOUN
admet-2214	104	7	(	(	PUNCT
admet-2214	104	8	nps	nps	PROPN
admet-2214	104	9	)	)	PUNCT
admet-2214	104	10	have	have	AUX
admet-2214	104	11	been	be	AUX
admet-2214	104	12	covered	cover	VERB
admet-2214	104	13	with	with	ADP
admet-2214	104	14	amphiphilic	amphiphilic	ADJ
admet-2214	104	15	peptides	peptide	NOUN
admet-2214	104	16	to	to	PART
admet-2214	104	17	enhance	enhance	VERB
admet-2214	104	18	their	their	PRON
admet-2214	104	19	absorption	absorption	NOUN
admet-2214	104	20	by	by	ADP
admet-2214	104	21	blood	blood	NOUN
admet-2214	104	22	-	-	PUNCT
admet-2214	104	23	brain	brain	NOUN
admet-2214	104	24	barrier	barrier	NOUN
admet-2214	104	25	(	(	PUNCT
admet-2214	104	26	bbb	bbb	NOUN
admet-2214	104	27	)	)	PUNCT
admet-2214	104	28	endothelial	endothelial	ADJ
admet-2214	104	29	cells	cell	NOUN
admet-2214	104	30	.	.	PUNCT
admet-2214	105	1	furthermore	furthermore	ADV
admet-2214	105	2	,	,	PUNCT
admet-2214	105	3	the	the	DET
admet-2214	105	4	quantity	quantity	NOUN
admet-2214	105	5	of	of	ADP
admet-2214	105	6	ligands	ligand	NOUN
admet-2214	105	7	and	and	CCONJ
admet-2214	105	8	their	their	PRON
admet-2214	105	9	receptor	receptor	NOUN
admet-2214	105	10	affinity	affinity	NOUN
admet-2214	105	11	significantly	significantly	ADV
admet-2214	105	12	influence	influence	VERB
admet-2214	105	13	the	the	DET
admet-2214	105	14	transportation	transportation	NOUN
admet-2214	105	15	of	of	ADP
admet-2214	105	16	nanoparticles	nanoparticle	NOUN
admet-2214	105	17	across	across	ADP
admet-2214	105	18	the	the	DET
admet-2214	105	19	blood	blood	NOUN
admet-2214	105	20	-	-	PUNCT
admet-2214	105	21	brain	brain	NOUN
admet-2214	105	22	barrier	barrier	NOUN
admet-2214	105	23	(	(	PUNCT
admet-2214	105	24	avidity	avidity	NOUN
admet-2214	105	25	)	)	PUNCT
admet-2214	105	26	.	.	PUNCT
admet-2214	106	1	the	the	DET
admet-2214	106	2	density	density	NOUN
admet-2214	106	3	of	of	ADP
admet-2214	106	4	ligands	ligand	NOUN
admet-2214	106	5	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	106	6	z.	z.	PROPN
admet-2214	106	7	presswala	presswala	PROPN
admet-2214	106	8	et	et	PROPN
admet-2214	106	9	al	al	PROPN
admet-2214	106	10	.	.	PROPN
admet-2214	106	11	admet	admet	PROPN
admet-2214	106	12	&	&	CCONJ
admet-2214	106	13	dmpk	dmpk	PROPN
admet-2214	106	14	12(3	12(3	PROPN
admet-2214	106	15	)	)	PUNCT
admet-2214	106	16	(	(	PUNCT
admet-2214	106	17	2024	2024	NUM
admet-2214	106	18	)	)	PUNCT
admet-2214	106	19	403	403	NUM
admet-2214	106	20	-	-	SYM
admet-2214	106	21	429	429	NUM
admet-2214	106	22	410	410	NUM
admet-2214	106	23	is	be	AUX
admet-2214	106	24	determined	determine	VERB
admet-2214	106	25	by	by	ADP
admet-2214	106	26	both	both	CCONJ
admet-2214	106	27	the	the	DET
admet-2214	106	28	surface	surface	NOUN
admet-2214	106	29	area	area	NOUN
admet-2214	106	30	of	of	ADP
admet-2214	106	31	the	the	DET
admet-2214	106	32	nanoparticles	nanoparticle	NOUN
admet-2214	106	33	and	and	CCONJ
admet-2214	106	34	the	the	DET
admet-2214	106	35	size	size	NOUN
admet-2214	106	36	of	of	ADP
admet-2214	106	37	the	the	DET
admet-2214	106	38	ligands	ligand	NOUN
admet-2214	106	39	.	.	PUNCT
admet-2214	107	1	usually	usually	ADV
admet-2214	107	2	,	,	PUNCT
admet-2214	107	3	the	the	DET
admet-2214	107	4	binding	bind	VERB
admet-2214	107	5	strength	strength	NOUN
admet-2214	107	6	between	between	ADP
admet-2214	107	7	the	the	DET
admet-2214	107	8	ligand	ligand	NOUN
admet-2214	107	9	and	and	CCONJ
admet-2214	107	10	its	its	PRON
admet-2214	107	11	receptor	receptor	NOUN
admet-2214	107	12	decreases	decrease	VERB
admet-2214	107	13	when	when	SCONJ
admet-2214	107	14	the	the	DET
admet-2214	107	15	ligand	ligand	NOUN
admet-2214	107	16	is	be	AUX
admet-2214	107	17	attached	attach	VERB
admet-2214	107	18	to	to	ADP
admet-2214	107	19	nanoparticles	nanoparticle	NOUN
admet-2214	107	20	(	(	PUNCT
admet-2214	107	21	nps	nps	PROPN
admet-2214	107	22	)	)	PUNCT
admet-2214	107	23	.	.	PUNCT
admet-2214	108	1	the	the	DET
admet-2214	108	2	avidity	avidity	NOUN
admet-2214	108	3	and	and	CCONJ
admet-2214	108	4	selectivity	selectivity	NOUN
admet-2214	108	5	of	of	ADP
admet-2214	108	6	the	the	DET
admet-2214	108	7	targeted	target	VERB
admet-2214	108	8	ligands	ligand	NOUN
admet-2214	108	9	are	be	AUX
admet-2214	108	10	enhanced	enhance	VERB
admet-2214	108	11	when	when	SCONJ
admet-2214	108	12	numerous	numerous	ADJ
admet-2214	108	13	ligands	ligand	NOUN
admet-2214	108	14	are	be	AUX
admet-2214	108	15	conjugated	conjugate	VERB
admet-2214	108	16	.	.	PUNCT
admet-2214	109	1	nevertheless	nevertheless	ADV
admet-2214	109	2	,	,	PUNCT
admet-2214	109	3	np	np	DET
admet-2214	109	4	attraction	attraction	NOUN
admet-2214	109	5	's	's	PART
admet-2214	109	6	intensity	intensity	NOUN
admet-2214	109	7	must	must	AUX
admet-2214	109	8	be	be	AUX
admet-2214	109	9	adjusted	adjust	VERB
admet-2214	109	10	to	to	PART
admet-2214	109	11	achieve	achieve	VERB
admet-2214	109	12	efficient	efficient	ADJ
admet-2214	109	13	bbb	bbb	NOUN
admet-2214	109	14	transcytosis	transcytosis	NOUN
admet-2214	110	1	[	[	X
admet-2214	110	2	44,45	44,45	X
admet-2214	110	3	]	]	X
admet-2214	110	4	.	.	PUNCT
admet-2214	111	1	in	in	ADP
admet-2214	111	2	the	the	DET
admet-2214	111	3	fourth	fourth	ADJ
admet-2214	111	4	scenario	scenario	NOUN
admet-2214	111	5	,	,	PUNCT
admet-2214	111	6	for	for	ADP
admet-2214	111	7	instance	instance	NOUN
admet-2214	111	8	,	,	PUNCT
admet-2214	111	9	pegylated	pegylate	VERB
admet-2214	111	10	nps	nps	PROPN
admet-2214	111	11	accumulate	accumulate	VERB
admet-2214	111	12	more	more	ADV
admet-2214	111	13	efficiently	efficiently	ADV
admet-2214	111	14	in	in	ADP
admet-2214	111	15	the	the	DET
admet-2214	111	16	brain	brain	NOUN
admet-2214	111	17	,	,	PUNCT
admet-2214	111	18	which	which	PRON
admet-2214	111	19	results	result	VERB
admet-2214	111	20	in	in	ADP
admet-2214	111	21	improved	improved	ADJ
admet-2214	111	22	blood	blood	NOUN
admet-2214	111	23	circulation	circulation	NOUN
admet-2214	111	24	time	time	NOUN
admet-2214	112	1	[	[	X
admet-2214	112	2	45,46	45,46	NOUN
admet-2214	112	3	]	]	PUNCT
admet-2214	112	4	.	.	PUNCT
admet-2214	113	1	in	in	ADP
admet-2214	113	2	conclusion	conclusion	NOUN
admet-2214	113	3	,	,	PUNCT
admet-2214	113	4	various	various	ADJ
admet-2214	113	5	factors	factor	NOUN
admet-2214	113	6	affect	affect	VERB
admet-2214	113	7	the	the	DET
admet-2214	113	8	transportation	transportation	NOUN
admet-2214	113	9	of	of	ADP
admet-2214	113	10	nanoparticles	nanoparticle	NOUN
admet-2214	113	11	(	(	PUNCT
admet-2214	113	12	nps	nps	PROPN
admet-2214	113	13	)	)	PUNCT
admet-2214	113	14	via	via	ADP
admet-2214	113	15	the	the	DET
admet-2214	113	16	blood	blood	NOUN
admet-2214	113	17	-	-	PUNCT
admet-2214	113	18	brain	brain	NOUN
admet-2214	113	19	barrier	barrier	NOUN
admet-2214	113	20	(	(	PUNCT
admet-2214	113	21	bbb	bbb	NOUN
admet-2214	113	22	)	)	PUNCT
admet-2214	113	23	to	to	ADP
admet-2214	113	24	varying	vary	VERB
admet-2214	113	25	degrees	degree	NOUN
admet-2214	113	26	.	.	PUNCT
admet-2214	114	1	role	role	NOUN
admet-2214	114	2	of	of	ADP
admet-2214	114	3	nanocarriers	nanocarrier	NOUN
admet-2214	114	4	in	in	ADP
admet-2214	114	5	dipg	dipg	NOUN
admet-2214	114	6	to	to	PART
admet-2214	114	7	boost	boost	VERB
admet-2214	114	8	the	the	DET
admet-2214	114	9	brain	brain	NOUN
admet-2214	114	10	penetration	penetration	NOUN
admet-2214	114	11	of	of	ADP
admet-2214	114	12	nanocarriers	nanocarrier	NOUN
admet-2214	114	13	carrying	carry	VERB
admet-2214	114	14	chemotherapeutic	chemotherapeutic	ADJ
admet-2214	114	15	medicines	medicine	NOUN
admet-2214	114	16	against	against	ADP
admet-2214	114	17	glioma	glioma	NOUN
admet-2214	114	18	tumours	tumours	NOUN
admet-2214	114	19	,	,	PUNCT
admet-2214	114	20	several	several	ADJ
admet-2214	114	21	strategies	strategy	NOUN
admet-2214	114	22	involve	involve	VERB
admet-2214	114	23	changing	change	VERB
admet-2214	114	24	the	the	DET
admet-2214	114	25	bbb	bbb	NOUN
admet-2214	114	26	.	.	PUNCT
admet-2214	115	1	only	only	ADV
admet-2214	115	2	those	those	DET
admet-2214	115	3	nanocarriers	nanocarrier	NOUN
admet-2214	115	4	that	that	PRON
admet-2214	115	5	can	can	AUX
admet-2214	115	6	carry	carry	VERB
admet-2214	115	7	anticancer	anticancer	NOUN
admet-2214	115	8	medications	medication	NOUN
admet-2214	115	9	to	to	PART
admet-2214	115	10	brain	brain	VERB
admet-2214	115	11	tumours	tumour	NOUN
admet-2214	115	12	without	without	ADP
admet-2214	115	13	disrupting	disrupt	VERB
admet-2214	115	14	the	the	DET
admet-2214	115	15	bbb	bbb	NOUN
admet-2214	115	16	are	be	AUX
admet-2214	115	17	included	include	VERB
admet-2214	115	18	in	in	ADP
admet-2214	115	19	the	the	DET
admet-2214	115	20	subsequent	subsequent	ADJ
admet-2214	115	21	discussion	discussion	NOUN
admet-2214	115	22	of	of	ADP
admet-2214	115	23	nanocarriers	nanocarrier	NOUN
admet-2214	115	24	.	.	PUNCT
admet-2214	116	1	however	however	ADV
admet-2214	116	2	,	,	PUNCT
admet-2214	116	3	the	the	DET
admet-2214	116	4	primary	primary	ADJ
admet-2214	116	5	justification	justification	NOUN
admet-2214	116	6	for	for	ADP
admet-2214	116	7	using	use	VERB
admet-2214	116	8	nanocarriers	nanocarrier	NOUN
admet-2214	116	9	in	in	ADP
admet-2214	116	10	high	high	ADJ
admet-2214	116	11	-	-	PUNCT
admet-2214	116	12	grade	grade	NOUN
admet-2214	116	13	glioma	glioma	NOUN
admet-2214	116	14	treatment	treatment	NOUN
admet-2214	116	15	is	be	AUX
admet-2214	116	16	that	that	SCONJ
admet-2214	116	17	over	over	ADP
admet-2214	116	18	98	98	NUM
admet-2214	116	19	%	%	NOUN
admet-2214	116	20	of	of	ADP
admet-2214	116	21	medicines	medicine	NOUN
admet-2214	116	22	fail	fail	VERB
admet-2214	116	23	to	to	PART
admet-2214	116	24	cross	cross	VERB
admet-2214	116	25	the	the	DET
admet-2214	116	26	bbb	bbb	NOUN
admet-2214	117	1	[	[	X
admet-2214	117	2	3	3	NUM
admet-2214	117	3	]	]	PUNCT
admet-2214	117	4	.	.	PUNCT
admet-2214	118	1	role	role	NOUN
admet-2214	118	2	of	of	ADP
admet-2214	118	3	nanoparticles	nanoparticle	NOUN
admet-2214	118	4	as	as	ADP
admet-2214	118	5	a	a	DET
admet-2214	118	6	diagnostic	diagnostic	ADJ
admet-2214	118	7	agent	agent	NOUN
admet-2214	118	8	in	in	ADP
admet-2214	118	9	dipg	dipg	NOUN
admet-2214	118	10	currently	currently	ADV
admet-2214	118	11	,	,	PUNCT
admet-2214	118	12	with	with	ADP
admet-2214	118	13	morphological	morphological	ADJ
admet-2214	118	14	investigation	investigation	NOUN
admet-2214	118	15	of	of	ADP
admet-2214	118	16	tissues	tissue	NOUN
admet-2214	118	17	or	or	CCONJ
admet-2214	118	18	cells	cell	NOUN
admet-2214	118	19	and	and	CCONJ
admet-2214	118	20	with	with	ADP
admet-2214	118	21	the	the	DET
admet-2214	118	22	help	help	NOUN
admet-2214	118	23	of	of	ADP
admet-2214	118	24	imaging	imaging	NOUN
admet-2214	118	25	tools	tool	NOUN
admet-2214	118	26	,	,	PUNCT
admet-2214	118	27	early	early	ADJ
admet-2214	118	28	cancer	cancer	NOUN
admet-2214	118	29	can	can	AUX
admet-2214	118	30	be	be	AUX
admet-2214	118	31	diagnosed	diagnose	VERB
admet-2214	118	32	.	.	PUNCT
admet-2214	119	1	most	most	ADJ
admet-2214	119	2	imaging	imaging	NOUN
admet-2214	119	3	techniques	technique	NOUN
admet-2214	119	4	,	,	PUNCT
admet-2214	119	5	such	such	ADJ
admet-2214	119	6	as	as	ADP
admet-2214	119	7	x	x	NOUN
admet-2214	119	8	-	-	NOUN
admet-2214	119	9	rays	ray	NOUN
admet-2214	119	10	,	,	PUNCT
admet-2214	119	11	mris	mri	NOUN
admet-2214	119	12	,	,	PUNCT
admet-2214	119	13	computed	compute	VERB
admet-2214	119	14	tomography	tomography	NOUN
admet-2214	119	15	(	(	PUNCT
admet-2214	119	16	ct	ct	PROPN
admet-2214	119	17	)	)	PUNCT
admet-2214	119	18	,	,	PUNCT
admet-2214	119	19	endoscopies	endoscopy	NOUN
admet-2214	119	20	,	,	PUNCT
admet-2214	119	21	and	and	CCONJ
admet-2214	119	22	ultrasounds	ultrasound	NOUN
admet-2214	119	23	,	,	PUNCT
admet-2214	119	24	can	can	AUX
admet-2214	119	25	only	only	ADV
admet-2214	119	26	detect	detect	VERB
admet-2214	119	27	cancer	cancer	NOUN
admet-2214	119	28	when	when	SCONJ
admet-2214	119	29	the	the	DET
admet-2214	119	30	tissue	tissue	NOUN
admet-2214	119	31	has	have	AUX
admet-2214	119	32	undergone	undergo	VERB
admet-2214	119	33	a	a	DET
admet-2214	119	34	conspicuous	conspicuous	ADJ
admet-2214	119	35	change	change	NOUN
admet-2214	119	36	[	[	X
admet-2214	119	37	47	47	NUM
admet-2214	119	38	]	]	PUNCT
admet-2214	119	39	.	.	PUNCT
admet-2214	120	1	although	although	SCONJ
admet-2214	120	2	nanotechnology	nanotechnology	NOUN
admet-2214	120	3	has	have	AUX
admet-2214	120	4	not	not	PART
admet-2214	120	5	yet	yet	ADV
admet-2214	120	6	been	be	AUX
admet-2214	120	7	used	use	VERB
admet-2214	120	8	in	in	ADP
admet-2214	120	9	clinical	clinical	ADJ
admet-2214	120	10	settings	setting	NOUN
admet-2214	120	11	to	to	PART
admet-2214	120	12	diagnose	diagnose	VERB
admet-2214	120	13	cancer	cancer	NOUN
admet-2214	120	14	,	,	PUNCT
admet-2214	120	15	it	it	PRON
admet-2214	120	16	is	be	AUX
admet-2214	120	17	presently	presently	ADV
admet-2214	120	18	available	available	ADJ
admet-2214	120	19	in	in	ADP
admet-2214	120	20	a	a	DET
admet-2214	120	21	number	number	NOUN
admet-2214	120	22	of	of	ADP
admet-2214	120	23	medical	medical	ADJ
admet-2214	120	24	screenings	screening	NOUN
admet-2214	120	25	and	and	CCONJ
admet-2214	120	26	testing	testing	NOUN
admet-2214	120	27	[	[	X
admet-2214	120	28	48	48	NUM
admet-2214	120	29	]	]	PUNCT
admet-2214	120	30	.	.	PUNCT
admet-2214	121	1	nanoparticles	nanoparticle	NOUN
admet-2214	121	2	are	be	AUX
admet-2214	121	3	used	use	VERB
admet-2214	121	4	to	to	PART
admet-2214	121	5	collect	collect	VERB
admet-2214	121	6	cancer	cancer	NOUN
admet-2214	121	7	biomarkers	biomarker	NOUN
admet-2214	121	8	for	for	ADP
admet-2214	121	9	cancer	cancer	NOUN
admet-2214	121	10	detection	detection	NOUN
admet-2214	121	11	,	,	PUNCT
admet-2214	121	12	including	include	VERB
admet-2214	121	13	cancer	cancer	NOUN
admet-2214	121	14	-	-	PUNCT
admet-2214	121	15	associated	associate	VERB
admet-2214	121	16	proteins	protein	NOUN
admet-2214	121	17	,	,	PUNCT
admet-2214	121	18	circulating	circulate	VERB
admet-2214	121	19	tumour	tumour	ADJ
admet-2214	121	20	dna	dna	NOUN
admet-2214	121	21	,	,	PUNCT
admet-2214	121	22	circulating	circulate	VERB
admet-2214	121	23	tumour	tumour	ADJ
admet-2214	121	24	cells	cell	NOUN
admet-2214	121	25	,	,	PUNCT
admet-2214	121	26	and	and	CCONJ
admet-2214	121	27	exosomes	exosome	NOUN
admet-2214	121	28	[	[	X
admet-2214	121	29	49	49	NUM
admet-2214	121	30	]	]	PUNCT
admet-2214	121	31	.	.	PUNCT
admet-2214	122	1	promising	promise	VERB
admet-2214	122	2	nanotechnology	nanotechnology	PROPN
admet-2214	122	3	diagnostic	diagnostic	ADJ
admet-2214	122	4	techniques	technique	NOUN
admet-2214	122	5	are	be	AUX
admet-2214	122	6	being	be	AUX
admet-2214	122	7	created	create	VERB
admet-2214	122	8	to	to	PART
admet-2214	122	9	provide	provide	VERB
admet-2214	122	10	on	on	ADP
admet-2214	122	11	-	-	PUNCT
admet-2214	122	12	demand	demand	NOUN
admet-2214	122	13	,	,	PUNCT
admet-2214	122	14	practical	practical	ADJ
admet-2214	122	15	,	,	PUNCT
admet-2214	122	16	and	and	CCONJ
admet-2214	122	17	affordable	affordable	ADJ
admet-2214	122	18	cancer	cancer	NOUN
admet-2214	122	19	detection	detection	NOUN
admet-2214	122	20	and	and	CCONJ
admet-2214	122	21	diagnosis	diagnosis	NOUN
admet-2214	122	22	tools	tool	NOUN
admet-2214	122	23	.	.	PUNCT
admet-2214	123	1	as	as	ADP
admet-2214	123	2	a	a	DET
admet-2214	123	3	result	result	NOUN
admet-2214	123	4	of	of	ADP
admet-2214	123	5	their	their	PRON
admet-2214	123	6	superior	superior	ADJ
admet-2214	123	7	volume	volume	NOUN
admet-2214	123	8	-	-	PUNCT
admet-2214	123	9	to	to	ADP
admet-2214	123	10	-	-	PUNCT
admet-2214	123	11	surface	surface	NOUN
admet-2214	123	12	ratio	ratio	NOUN
admet-2214	123	13	when	when	SCONJ
admet-2214	123	14	compared	compare	VERB
admet-2214	123	15	to	to	ADP
admet-2214	123	16	bulk	bulk	ADJ
admet-2214	123	17	materials	material	NOUN
admet-2214	123	18	,	,	PUNCT
admet-2214	123	19	many	many	ADJ
admet-2214	123	20	nanotechnologies	nanotechnology	NOUN
admet-2214	123	21	,	,	PUNCT
admet-2214	123	22	including	include	VERB
admet-2214	123	23	quantum	quantum	ADJ
admet-2214	123	24	dots	dot	NOUN
admet-2214	123	25	,	,	PUNCT
admet-2214	123	26	gold	gold	NOUN
admet-2214	123	27	nanoparticles	nanoparticle	NOUN
admet-2214	123	28	,	,	PUNCT
admet-2214	123	29	magnetic	magnetic	ADJ
admet-2214	123	30	nanoparticles	nanoparticle	NOUN
admet-2214	123	31	,	,	PUNCT
admet-2214	123	32	and	and	CCONJ
admet-2214	123	33	polymer	polymer	NOUN
admet-2214	123	34	dots	dot	NOUN
admet-2214	123	35	,	,	PUNCT
admet-2214	123	36	are	be	AUX
admet-2214	123	37	used	use	VERB
admet-2214	123	38	for	for	ADP
admet-2214	123	39	cancer	cancer	NOUN
admet-2214	123	40	detection	detection	NOUN
admet-2214	123	41	.	.	PUNCT
admet-2214	124	1	this	this	DET
admet-2214	124	2	property	property	NOUN
admet-2214	124	3	enables	enable	VERB
admet-2214	124	4	the	the	DET
admet-2214	124	5	dense	dense	ADJ
admet-2214	124	6	coating	coating	NOUN
admet-2214	124	7	of	of	ADP
admet-2214	124	8	antibodies	antibody	NOUN
admet-2214	124	9	,	,	PUNCT
admet-2214	124	10	small	small	ADJ
admet-2214	124	11	molecules	molecule	NOUN
admet-2214	124	12	,	,	PUNCT
admet-2214	124	13	peptides	peptide	NOUN
admet-2214	124	14	,	,	PUNCT
admet-2214	124	15	aptamers	aptamer	NOUN
admet-2214	124	16	,	,	PUNCT
admet-2214	124	17	and	and	CCONJ
admet-2214	124	18	other	other	ADJ
admet-2214	124	19	substances	substance	NOUN
admet-2214	124	20	on	on	ADP
admet-2214	124	21	nanoparticle	nanoparticle	NOUN
admet-2214	124	22	surfaces	surface	NOUN
admet-2214	124	23	.	.	PUNCT
admet-2214	125	1	such	such	ADJ
admet-2214	125	2	compounds	compound	NOUN
admet-2214	125	3	can	can	AUX
admet-2214	125	4	bind	bind	VERB
admet-2214	125	5	to	to	ADP
admet-2214	125	6	and	and	CCONJ
admet-2214	125	7	identify	identify	VERB
admet-2214	125	8	particular	particular	ADJ
admet-2214	125	9	cancer	cancer	NOUN
admet-2214	125	10	molecules	molecule	NOUN
admet-2214	125	11	[	[	X
admet-2214	125	12	47	47	NUM
admet-2214	125	13	]	]	PUNCT
admet-2214	125	14	.	.	PUNCT
admet-2214	126	1	role	role	NOUN
admet-2214	126	2	of	of	ADP
admet-2214	126	3	nano	nano	NOUN
admet-2214	126	4	formulations	formulation	NOUN
admet-2214	126	5	as	as	ADP
admet-2214	126	6	a	a	DET
admet-2214	126	7	therapeutic	therapeutic	ADJ
admet-2214	126	8	agent	agent	NOUN
admet-2214	126	9	in	in	ADP
admet-2214	126	10	dipg	dipg	NOUN
admet-2214	126	11	as	as	SCONJ
admet-2214	126	12	is	be	AUX
admet-2214	126	13	common	common	ADJ
admet-2214	126	14	knowledge	knowledge	NOUN
admet-2214	126	15	,	,	PUNCT
admet-2214	126	16	the	the	DET
admet-2214	126	17	bbb	bbb	NOUN
admet-2214	126	18	protects	protect	VERB
admet-2214	126	19	against	against	ADP
admet-2214	126	20	harmful	harmful	ADJ
admet-2214	126	21	substances	substance	NOUN
admet-2214	126	22	entering	enter	VERB
admet-2214	126	23	the	the	DET
admet-2214	126	24	brain	brain	NOUN
admet-2214	126	25	.	.	PUNCT
admet-2214	127	1	endothelial	endothelial	ADJ
admet-2214	127	2	cells	cell	NOUN
admet-2214	127	3	are	be	AUX
admet-2214	127	4	arranged	arrange	VERB
admet-2214	127	5	closely	closely	ADV
admet-2214	127	6	together	together	ADV
admet-2214	127	7	and	and	CCONJ
admet-2214	127	8	are	be	AUX
admet-2214	127	9	found	find	VERB
admet-2214	127	10	along	along	ADP
admet-2214	127	11	the	the	DET
admet-2214	127	12	brain	brain	NOUN
admet-2214	127	13	's	's	PART
admet-2214	127	14	capillaries	capillary	NOUN
admet-2214	127	15	.	.	PUNCT
admet-2214	128	1	bbb	bbb	PROPN
admet-2214	128	2	is	be	AUX
admet-2214	128	3	a	a	DET
admet-2214	128	4	filter	filter	NOUN
admet-2214	128	5	for	for	ADP
admet-2214	128	6	passive	passive	ADJ
admet-2214	128	7	transport	transport	NOUN
admet-2214	128	8	and	and	CCONJ
admet-2214	128	9	is	be	AUX
admet-2214	128	10	selectively	selectively	ADV
admet-2214	128	11	permeable	permeable	ADJ
admet-2214	128	12	to	to	ADP
admet-2214	128	13	water	water	NOUN
admet-2214	128	14	,	,	PUNCT
admet-2214	128	15	nutrients	nutrient	NOUN
admet-2214	128	16	,	,	PUNCT
admet-2214	128	17	and	and	CCONJ
admet-2214	128	18	hydrophobic	hydrophobic	NOUN
admet-2214	128	19	compounds	compound	NOUN
admet-2214	128	20	[	[	X
admet-2214	128	21	50	50	NUM
admet-2214	128	22	]	]	PUNCT
admet-2214	128	23	.	.	PUNCT
admet-2214	129	1	its	its	PRON
admet-2214	129	2	defense	defense	NOUN
admet-2214	129	3	mechanism	mechanism	NOUN
admet-2214	129	4	comprises	comprise	VERB
admet-2214	129	5	the	the	DET
admet-2214	129	6	facilitated	facilitate	VERB
admet-2214	129	7	efflux	efflux	NOUN
admet-2214	129	8	of	of	ADP
admet-2214	129	9	bacteria	bacteria	NOUN
admet-2214	129	10	and	and	CCONJ
admet-2214	129	11	poisons	poison	NOUN
admet-2214	129	12	with	with	ADP
admet-2214	129	13	lipid	lipid	NOUN
admet-2214	129	14	solubility	solubility	NOUN
admet-2214	129	15	via	via	ADP
admet-2214	129	16	p	p	NOUN
admet-2214	129	17	-	-	PUNCT
admet-2214	129	18	gp	gp	NOUN
admet-2214	129	19	.	.	PUNCT
admet-2214	130	1	tight	tight	ADJ
admet-2214	130	2	junctions	junction	NOUN
admet-2214	130	3	are	be	AUX
admet-2214	130	4	fundamental	fundamental	ADJ
admet-2214	130	5	structural	structural	ADJ
admet-2214	130	6	elements	element	NOUN
admet-2214	130	7	necessary	necessary	ADJ
admet-2214	130	8	for	for	SCONJ
admet-2214	130	9	endothelial	endothelial	ADJ
admet-2214	130	10	cells	cell	NOUN
admet-2214	130	11	to	to	PART
admet-2214	130	12	function	function	VERB
admet-2214	130	13	.	.	PUNCT
admet-2214	131	1	these	these	DET
admet-2214	131	2	tight	tight	ADJ
admet-2214	131	3	connections	connection	NOUN
admet-2214	131	4	of	of	ADP
admet-2214	131	5	endothelial	endothelial	ADJ
admet-2214	131	6	cells	cell	NOUN
admet-2214	131	7	are	be	AUX
admet-2214	131	8	absent	absent	ADJ
admet-2214	131	9	from	from	ADP
admet-2214	131	10	normal	normal	ADJ
admet-2214	131	11	capillaries	capillary	NOUN
admet-2214	131	12	of	of	ADP
admet-2214	131	13	blood	blood	NOUN
admet-2214	131	14	circulation	circulation	NOUN
admet-2214	131	15	,	,	PUNCT
admet-2214	131	16	but	but	CCONJ
admet-2214	131	17	the	the	DET
admet-2214	131	18	bbb	bbb	ADJ
admet-2214	131	19	endothelial	endothelial	NOUN
admet-2214	131	20	cells	cell	NOUN
admet-2214	131	21	'	'	PART
admet-2214	131	22	tight	tight	ADJ
admet-2214	131	23	junctions	junction	NOUN
admet-2214	131	24	shield	shield	VERB
admet-2214	131	25	the	the	DET
admet-2214	131	26	brain	brain	NOUN
admet-2214	131	27	[	[	X
admet-2214	131	28	51	51	NUM
admet-2214	131	29	]	]	PUNCT
admet-2214	131	30	.	.	PUNCT
admet-2214	132	1	most	most	ADJ
admet-2214	132	2	medications	medication	NOUN
admet-2214	132	3	fail	fail	VERB
admet-2214	132	4	to	to	PART
admet-2214	132	5	pass	pass	VERB
admet-2214	132	6	this	this	DET
admet-2214	132	7	barrier	barrier	NOUN
admet-2214	132	8	and	and	CCONJ
admet-2214	132	9	lose	lose	VERB
admet-2214	132	10	their	their	PRON
admet-2214	132	11	therapeutic	therapeutic	ADJ
admet-2214	132	12	benefits	benefit	NOUN
admet-2214	132	13	,	,	PUNCT
admet-2214	132	14	rendering	render	VERB
admet-2214	132	15	neurological	neurological	ADJ
admet-2214	132	16	patients	patient	NOUN
admet-2214	132	17	incurable	incurable	ADJ
admet-2214	132	18	.	.	PUNCT
admet-2214	133	1	the	the	DET
admet-2214	133	2	most	most	ADV
admet-2214	133	3	extensively	extensively	ADV
admet-2214	133	4	researched	research	VERB
admet-2214	133	5	delivery	delivery	NOUN
admet-2214	133	6	systems	system	NOUN
admet-2214	133	7	for	for	ADP
admet-2214	133	8	bbb	bbb	PROPN
admet-2214	133	9	translocation	translocation	NOUN
admet-2214	133	10	,	,	PUNCT
admet-2214	133	11	nanocarriers	nanocarrier	NOUN
admet-2214	133	12	are	be	AUX
admet-2214	133	13	effective	effective	ADJ
admet-2214	133	14	in	in	ADP
admet-2214	133	15	targeting	target	VERB
admet-2214	133	16	or	or	CCONJ
admet-2214	133	17	utilizing	utilize	VERB
admet-2214	133	18	specific	specific	ADJ
admet-2214	133	19	biological	biological	ADJ
admet-2214	133	20	substances	substance	NOUN
admet-2214	133	21	,	,	PUNCT
admet-2214	133	22	receptors	receptor	NOUN
admet-2214	133	23	,	,	PUNCT
admet-2214	133	24	carriers	carrier	NOUN
admet-2214	133	25	,	,	PUNCT
admet-2214	133	26	or	or	CCONJ
admet-2214	133	27	processes	process	NOUN
admet-2214	133	28	of	of	ADP
admet-2214	133	29	the	the	DET
admet-2214	133	30	brain	brain	NOUN
admet-2214	133	31	.	.	PUNCT
admet-2214	134	1	due	due	ADP
admet-2214	134	2	to	to	ADP
admet-2214	134	3	their	their	PRON
admet-2214	134	4	promising	promising	ADJ
admet-2214	134	5	properties	property	NOUN
admet-2214	134	6	and	and	CCONJ
admet-2214	134	7	extensive	extensive	ADJ
admet-2214	134	8	uses	use	NOUN
admet-2214	134	9	in	in	ADP
admet-2214	134	10	neurological	neurological	ADJ
admet-2214	134	11	illnesses	illness	NOUN
admet-2214	134	12	,	,	PUNCT
admet-2214	134	13	the	the	DET
admet-2214	134	14	class	class	NOUN
admet-2214	134	15	of	of	ADP
admet-2214	134	16	polymeric	polymeric	ADJ
admet-2214	134	17	nanoparticles	nanoparticle	NOUN
admet-2214	134	18	and	and	CCONJ
admet-2214	134	19	lipid	lipid	NOUN
admet-2214	134	20	nanocarriers	nanocarrier	NOUN
admet-2214	134	21	such	such	ADJ
admet-2214	134	22	as	as	ADP
admet-2214	134	23	liposomes	liposome	NOUN
admet-2214	134	24	,	,	PUNCT
admet-2214	134	25	solid	solid	ADJ
admet-2214	134	26	lipid	lipid	NOUN
admet-2214	134	27	nanoparticles	nanoparticle	NOUN
admet-2214	134	28	,	,	PUNCT
admet-2214	134	29	micelles	micelle	NOUN
admet-2214	134	30	,	,	PUNCT
admet-2214	134	31	and	and	CCONJ
admet-2214	134	32	others	other	NOUN
admet-2214	134	33	are	be	AUX
admet-2214	134	34	receiving	receive	VERB
admet-2214	134	35	particular	particular	ADJ
admet-2214	134	36	attention	attention	NOUN
admet-2214	134	37	from	from	ADP
admet-2214	134	38	neuroscientists	neuroscientist	NOUN
admet-2214	134	39	[	[	X
admet-2214	134	40	52	52	NUM
admet-2214	134	41	]	]	PUNCT
admet-2214	134	42	.	.	PUNCT
admet-2214	135	1	various	various	ADJ
admet-2214	135	2	invasive	invasive	ADJ
admet-2214	135	3	and	and	CCONJ
admet-2214	135	4	non	non	ADJ
admet-2214	135	5	-	-	ADJ
admet-2214	135	6	invasive	invasive	ADJ
admet-2214	135	7	techniques	technique	NOUN
admet-2214	135	8	focused	focus	VERB
admet-2214	135	9	on	on	ADP
admet-2214	135	10	getting	get	VERB
admet-2214	135	11	past	past	ADP
admet-2214	135	12	the	the	DET
admet-2214	135	13	bbb	bbb	NOUN
admet-2214	135	14	's	's	PART
admet-2214	135	15	impediment	impediment	NOUN
admet-2214	135	16	and	and	CCONJ
admet-2214	135	17	focusing	focus	VERB
admet-2214	135	18	on	on	ADP
admet-2214	135	19	the	the	DET
admet-2214	135	20	necessary	necessary	ADJ
admet-2214	135	21	sick	sick	ADJ
admet-2214	135	22	areas	area	NOUN
admet-2214	135	23	of	of	ADP
admet-2214	135	24	the	the	DET
admet-2214	135	25	brain	brain	NOUN
admet-2214	135	26	have	have	AUX
admet-2214	135	27	been	be	AUX
admet-2214	135	28	developed	develop	VERB
admet-2214	135	29	in	in	ADP
admet-2214	135	30	recent	recent	ADJ
admet-2214	135	31	years	year	NOUN
admet-2214	136	1	[	[	X
admet-2214	136	2	53	53	NUM
admet-2214	136	3	]	]	PUNCT
admet-2214	136	4	.	.	PUNCT
admet-2214	137	1	hydrophilic	hydrophilic	ADJ
admet-2214	137	2	or	or	CCONJ
admet-2214	137	3	lipophilic	lipophilic	ADJ
admet-2214	137	4	admet	admet	PROPN
admet-2214	137	5	&	&	CCONJ
admet-2214	137	6	dmpk	dmpk	PROPN
admet-2214	137	7	12(3	12(3	PROPN
admet-2214	137	8	)	)	PUNCT
admet-2214	137	9	(	(	PUNCT
admet-2214	137	10	2024	2024	NUM
admet-2214	137	11	)	)	PUNCT
admet-2214	138	1	403	403	NUM
admet-2214	138	2	-	-	SYM
admet-2214	138	3	429	429	NUM
admet-2214	138	4	addressing	address	VERB
admet-2214	138	5	barriers	barrier	NOUN
admet-2214	138	6	in	in	ADP
admet-2214	138	7	diffuse	diffuse	ADJ
admet-2214	138	8	intrinsic	intrinsic	ADJ
admet-2214	138	9	pontine	pontine	ADJ
admet-2214	138	10	glioma	glioma	NOUN
admet-2214	138	11	doi	doi	NOUN
admet-2214	138	12	:	:	PUNCT
admet-2214	138	13	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	138	14	411	411	NUM
admet-2214	138	15	neuropharmaceutical	neuropharmaceutical	ADJ
admet-2214	138	16	substances	substance	NOUN
admet-2214	138	17	can	can	AUX
admet-2214	138	18	be	be	AUX
admet-2214	138	19	loaded	load	VERB
admet-2214	138	20	into	into	ADP
admet-2214	138	21	nanoscopic	nanoscopic	ADJ
admet-2214	138	22	formulations	formulation	NOUN
admet-2214	138	23	of	of	ADP
admet-2214	138	24	biodegradable/	biodegradable/	NUM
admet-2214	138	25	biocompatible/	biocompatible/	NUM
admet-2214	138	26	synthetic/	synthetic/	NUM
admet-2214	138	27	natural	natural	ADJ
admet-2214	138	28	polymers	polymer	NOUN
admet-2214	138	29	in	in	ADP
admet-2214	138	30	solid	solid	ADJ
admet-2214	138	31	or	or	CCONJ
admet-2214	138	32	solution	solution	NOUN
admet-2214	138	33	form	form	NOUN
admet-2214	138	34	,	,	PUNCT
admet-2214	138	35	protecting	protect	VERB
admet-2214	138	36	them	they	PRON
admet-2214	138	37	against	against	ADP
admet-2214	138	38	biological	biological	ADJ
admet-2214	138	39	and	and	CCONJ
admet-2214	138	40	chemical	chemical	ADJ
admet-2214	138	41	risks	risk	NOUN
admet-2214	138	42	[	[	X
admet-2214	138	43	54	54	NUM
admet-2214	138	44	]	]	PUNCT
admet-2214	138	45	.	.	PUNCT
admet-2214	139	1	the	the	DET
admet-2214	139	2	unique	unique	ADJ
admet-2214	139	3	advantages	advantage	NOUN
admet-2214	139	4	of	of	ADP
admet-2214	139	5	nano	nano	NOUN
admet-2214	139	6	formulations	formulation	NOUN
admet-2214	139	7	for	for	ADP
admet-2214	139	8	neurotherapeutic	neurotherapeutic	ADJ
admet-2214	139	9	drug	drug	NOUN
admet-2214	139	10	transportation	transportation	NOUN
admet-2214	139	11	include	include	VERB
admet-2214	139	12	size	size	NOUN
admet-2214	139	13	in	in	ADP
admet-2214	139	14	the	the	DET
admet-2214	139	15	nanometer	nanometer	NOUN
admet-2214	139	16	range	range	NOUN
admet-2214	139	17	,	,	PUNCT
admet-2214	139	18	morphological	morphological	ADJ
admet-2214	139	19	characterization	characterization	NOUN
admet-2214	139	20	,	,	PUNCT
admet-2214	139	21	efficient	efficient	ADJ
admet-2214	139	22	targeting	target	VERB
admet-2214	139	23	by	by	ADP
admet-2214	139	24	surface	surface	NOUN
admet-2214	139	25	modification	modification	NOUN
admet-2214	139	26	using	use	VERB
admet-2214	139	27	ligands	ligand	NOUN
admet-2214	139	28	,	,	PUNCT
admet-2214	139	29	a	a	DET
admet-2214	139	30	variety	variety	NOUN
admet-2214	139	31	of	of	ADP
admet-2214	139	32	administration	administration	NOUN
admet-2214	139	33	routes	route	NOUN
admet-2214	139	34	,	,	PUNCT
admet-2214	139	35	and	and	CCONJ
admet-2214	139	36	stimuli	stimulus	NOUN
admet-2214	139	37	-	-	PUNCT
admet-2214	139	38	sensitive	sensitive	ADJ
admet-2214	139	39	neurotherapeutic	neurotherapeutic	ADJ
admet-2214	139	40	release	release	NOUN
admet-2214	139	41	[	[	X
admet-2214	139	42	55	55	NUM
admet-2214	139	43	]	]	PUNCT
admet-2214	139	44	.	.	PUNCT
admet-2214	140	1	role	role	NOUN
admet-2214	140	2	of	of	ADP
admet-2214	140	3	lipid	lipid	NOUN
admet-2214	140	4	-	-	PUNCT
admet-2214	140	5	based	base	VERB
admet-2214	140	6	nanoparticles	nanoparticle	NOUN
admet-2214	140	7	in	in	ADP
admet-2214	140	8	dipg	dipg	NOUN
admet-2214	140	9	in	in	ADP
admet-2214	140	10	exploring	explore	VERB
admet-2214	140	11	the	the	DET
admet-2214	140	12	various	various	ADJ
admet-2214	140	13	types	type	NOUN
admet-2214	140	14	of	of	ADP
admet-2214	140	15	nanoparticles	nanoparticle	NOUN
admet-2214	140	16	discussed	discuss	VERB
admet-2214	140	17	above	above	ADV
admet-2214	140	18	,	,	PUNCT
admet-2214	140	19	it	it	PRON
admet-2214	140	20	is	be	AUX
admet-2214	140	21	noteworthy	noteworthy	ADJ
admet-2214	140	22	to	to	PART
admet-2214	140	23	highlight	highlight	VERB
admet-2214	140	24	the	the	DET
admet-2214	140	25	efficacy	efficacy	NOUN
admet-2214	140	26	of	of	ADP
admet-2214	140	27	lipid	lipid	NOUN
admet-2214	140	28	-	-	PUNCT
admet-2214	140	29	based	base	VERB
admet-2214	140	30	nanoparticles	nanoparticle	NOUN
admet-2214	140	31	,	,	PUNCT
admet-2214	140	32	such	such	ADJ
admet-2214	140	33	as	as	ADP
admet-2214	140	34	liposomes	liposome	NOUN
admet-2214	140	35	,	,	PUNCT
admet-2214	140	36	solid	solid	ADJ
admet-2214	140	37	lipid	lipid	NOUN
admet-2214	140	38	nanoparticles	nanoparticle	NOUN
admet-2214	140	39	and	and	CCONJ
admet-2214	140	40	nano	nano	NOUN
admet-2214	140	41	lipid	lipid	NOUN
admet-2214	140	42	carriers	carrier	NOUN
admet-2214	140	43	,	,	PUNCT
admet-2214	140	44	in	in	ADP
admet-2214	140	45	delivering	deliver	VERB
admet-2214	140	46	hydrophilic	hydrophilic	ADJ
admet-2214	140	47	and	and	CCONJ
admet-2214	140	48	lipophilic	lipophilic	ADJ
admet-2214	140	49	drugs	drug	NOUN
admet-2214	140	50	[	[	X
admet-2214	140	51	56,57	56,57	NOUN
admet-2214	140	52	]	]	X
admet-2214	140	53	.	.	PUNCT
admet-2214	141	1	in	in	ADP
admet-2214	141	2	nanoparticle	nanoparticle	NOUN
admet-2214	141	3	-	-	PUNCT
admet-2214	141	4	based	base	VERB
admet-2214	141	5	formulations	formulation	NOUN
admet-2214	141	6	,	,	PUNCT
admet-2214	141	7	lipids	lipid	NOUN
admet-2214	141	8	are	be	AUX
admet-2214	141	9	often	often	ADV
admet-2214	141	10	used	use	VERB
admet-2214	141	11	to	to	PART
admet-2214	141	12	encapsulate	encapsulate	VERB
admet-2214	141	13	or	or	CCONJ
admet-2214	141	14	carry	carry	VERB
admet-2214	141	15	active	active	ADJ
admet-2214	141	16	ingredients	ingredient	NOUN
admet-2214	141	17	such	such	ADJ
admet-2214	141	18	as	as	ADP
admet-2214	141	19	phospholipids	phospholipid	NOUN
admet-2214	141	20	,	,	PUNCT
admet-2214	141	21	triglycerides	triglyceride	NOUN
admet-2214	141	22	,	,	PUNCT
admet-2214	141	23	phytosterols	phytosterol	NOUN
admet-2214	141	24	,	,	PUNCT
admet-2214	141	25	and	and	CCONJ
admet-2214	141	26	fatty	fatty	NOUN
admet-2214	141	27	acids	acid	NOUN
admet-2214	141	28	.	.	PUNCT
admet-2214	142	1	different	different	ADJ
admet-2214	142	2	categories	category	NOUN
admet-2214	142	3	of	of	ADP
admet-2214	142	4	lipid	lipid	NOUN
admet-2214	142	5	-	-	PUNCT
admet-2214	142	6	based	base	VERB
admet-2214	142	7	nanoparticles	nanoparticle	NOUN
admet-2214	142	8	with	with	ADP
admet-2214	142	9	detailed	detailed	ADJ
admet-2214	142	10	structures	structure	NOUN
admet-2214	142	11	are	be	AUX
admet-2214	142	12	shown	show	VERB
admet-2214	142	13	in	in	ADP
admet-2214	142	14	figures	figure	NOUN
admet-2214	142	15	10	10	NUM
admet-2214	142	16	and	and	CCONJ
admet-2214	142	17	11	11	NUM
admet-2214	142	18	.	.	PUNCT
admet-2214	143	1	figure	figure	NOUN
admet-2214	143	2	10	10	NUM
admet-2214	143	3	.	.	PUNCT
admet-2214	144	1	the	the	DET
admet-2214	144	2	diagram	diagram	NOUN
admet-2214	144	3	illustrates	illustrate	VERB
admet-2214	144	4	three	three	NUM
admet-2214	144	5	distinct	distinct	ADJ
admet-2214	144	6	categories	category	NOUN
admet-2214	144	7	of	of	ADP
admet-2214	144	8	lipid	lipid	NOUN
admet-2214	144	9	-	-	PUNCT
admet-2214	144	10	based	base	VERB
admet-2214	144	11	nanoparticles	nanoparticle	NOUN
admet-2214	144	12	:	:	PUNCT
admet-2214	144	13	i	i	PRON
admet-2214	144	14	)	)	PUNCT
admet-2214	144	15	liposomes	liposome	NOUN
admet-2214	144	16	,	,	PUNCT
admet-2214	144	17	ii	ii	NOUN
admet-2214	144	18	)	)	PUNCT
admet-2214	144	19	solid	solid	ADJ
admet-2214	144	20	lipid	lipid	NOUN
admet-2214	144	21	nanoparticles	nanoparticle	NOUN
admet-2214	144	22	(	(	PUNCT
admet-2214	144	23	slns	slns	NOUN
admet-2214	144	24	)	)	PUNCT
admet-2214	144	25	,	,	PUNCT
admet-2214	144	26	iii	iii	X
admet-2214	144	27	)	)	PUNCT
admet-2214	144	28	nanostructured	nanostructure	VERB
admet-2214	144	29	lipid	lipid	NOUN
admet-2214	144	30	carriers	carrier	NOUN
admet-2214	144	31	(	(	PUNCT
admet-2214	144	32	nlcs	nlcs	PROPN
admet-2214	144	33	)	)	PUNCT
admet-2214	144	34	,	,	PUNCT
admet-2214	144	35	and	and	CCONJ
admet-2214	144	36	iv	iv	X
admet-2214	144	37	)	)	PUNCT
admet-2214	144	38	hybrid	hybrid	ADJ
admet-2214	144	39	lipid	lipid	NOUN
admet-2214	144	40	-	-	PUNCT
admet-2214	144	41	polymeric	polymeric	ADJ
admet-2214	144	42	nanoparticles	nanoparticle	NOUN
admet-2214	144	43	.	.	PUNCT
admet-2214	145	1	figure	figure	VERB
admet-2214	145	2	11	11	NUM
admet-2214	145	3	.	.	PUNCT
admet-2214	146	1	an	an	DET
admet-2214	146	2	illustrative	illustrative	ADJ
admet-2214	146	3	depiction	depiction	NOUN
admet-2214	146	4	of	of	ADP
admet-2214	146	5	various	various	ADJ
admet-2214	146	6	categories	category	NOUN
admet-2214	146	7	of	of	ADP
admet-2214	146	8	slns	slns	PROPN
admet-2214	146	9	(	(	PUNCT
admet-2214	146	10	solid	solid	ADJ
admet-2214	146	11	lipid	lipid	NOUN
admet-2214	146	12	nanoparticles	nanoparticle	NOUN
admet-2214	146	13	)	)	PUNCT
admet-2214	146	14	and	and	CCONJ
admet-2214	146	15	nlcs	nlcs	PROPN
admet-2214	146	16	(	(	PUNCT
admet-2214	146	17	nanostructured	nanostructure	VERB
admet-2214	146	18	lipid	lipid	NOUN
admet-2214	146	19	carriers	carrier	NOUN
admet-2214	146	20	)	)	PUNCT
admet-2214	146	21	.	.	PUNCT
admet-2214	147	1	slns	slns	PROPN
admet-2214	147	2	refer	refer	VERB
admet-2214	147	3	to	to	ADP
admet-2214	147	4	solid	solid	ADJ
admet-2214	147	5	lipid	lipid	ADJ
admet-2214	147	6	nanoparticles	nanoparticle	NOUN
admet-2214	147	7	that	that	PRON
admet-2214	147	8	can	can	AUX
admet-2214	147	9	be	be	AUX
admet-2214	147	10	categorized	categorize	VERB
admet-2214	147	11	into	into	ADP
admet-2214	147	12	three	three	NUM
admet-2214	147	13	models	model	NOUN
admet-2214	147	14	:	:	PUNCT
admet-2214	147	15	solid	solid	ADJ
admet-2214	147	16	solution	solution	NOUN
admet-2214	147	17	,	,	PUNCT
admet-2214	147	18	drug	drug	NOUN
admet-2214	147	19	-	-	PUNCT
admet-2214	147	20	filled	fill	VERB
admet-2214	147	21	shell	shell	NOUN
admet-2214	147	22	,	,	PUNCT
admet-2214	147	23	and	and	CCONJ
admet-2214	147	24	lipid	lipid	NOUN
admet-2214	147	25	-	-	PUNCT
admet-2214	147	26	filled	fill	VERB
admet-2214	147	27	shell	shell	NOUN
admet-2214	147	28	,	,	PUNCT
admet-2214	147	29	where	where	SCONJ
admet-2214	147	30	as	as	SCONJ
admet-2214	147	31	nlcs	nlcs	NOUN
admet-2214	147	32	subclasses	subclass	NOUN
admet-2214	147	33	are	be	AUX
admet-2214	147	34	characterized	characterize	VERB
admet-2214	147	35	by	by	ADP
admet-2214	147	36	imperfections	imperfection	NOUN
admet-2214	147	37	,	,	PUNCT
admet-2214	147	38	types	type	NOUN
admet-2214	147	39	lacking	lack	VERB
admet-2214	147	40	a	a	DET
admet-2214	147	41	definite	definite	ADJ
admet-2214	147	42	shape	shape	NOUN
admet-2214	147	43	,	,	PUNCT
admet-2214	147	44	types	type	NOUN
admet-2214	147	45	consisting	consist	VERB
admet-2214	147	46	of	of	ADP
admet-2214	147	47	numerous	numerous	ADJ
admet-2214	147	48	components	component	NOUN
admet-2214	147	49	role	role	NOUN
admet-2214	147	50	of	of	ADP
admet-2214	147	51	liposomes	liposome	NOUN
admet-2214	147	52	in	in	ADP
admet-2214	147	53	dipg	dipg	NOUN
admet-2214	147	54	originally	originally	ADV
admet-2214	147	55	identified	identify	VERB
admet-2214	147	56	in	in	ADP
admet-2214	147	57	1965	1965	NUM
admet-2214	147	58	,	,	PUNCT
admet-2214	147	59	liposomes	liposome	NOUN
admet-2214	147	60	are	be	AUX
admet-2214	147	61	spherical	spherical	ADJ
admet-2214	147	62	entities	entity	NOUN
admet-2214	147	63	comprising	comprise	VERB
admet-2214	147	64	an	an	DET
admet-2214	147	65	internal	internal	ADJ
admet-2214	147	66	aqueous	aqueous	ADJ
admet-2214	147	67	core	core	NOUN
admet-2214	147	68	and	and	CCONJ
admet-2214	147	69	an	an	DET
admet-2214	147	70	amphipathic	amphipathic	ADJ
admet-2214	147	71	phospholipid	phospholipid	NOUN
admet-2214	147	72	bilayer	bilayer	NOUN
admet-2214	147	73	[	[	X
admet-2214	147	74	58	58	NUM
admet-2214	147	75	]	]	PUNCT
admet-2214	147	76	.	.	PUNCT
admet-2214	148	1	liposomes	liposome	NOUN
admet-2214	148	2	possess	possess	VERB
admet-2214	148	3	a	a	DET
admet-2214	148	4	core	core	NOUN
admet-2214	148	5	-	-	PUNCT
admet-2214	148	6	shell	shell	NOUN
admet-2214	148	7	nanostructure	nanostructure	NOUN
admet-2214	148	8	that	that	PRON
admet-2214	148	9	enables	enable	VERB
admet-2214	148	10	the	the	DET
admet-2214	148	11	loading	loading	NOUN
admet-2214	148	12	of	of	ADP
admet-2214	148	13	hydrophilic	hydrophilic	ADJ
admet-2214	148	14	and	and	CCONJ
admet-2214	148	15	hydrophobic	hydrophobic	NOUN
admet-2214	148	16	compounds	compound	NOUN
admet-2214	148	17	.	.	PUNCT
admet-2214	149	1	typically	typically	ADV
admet-2214	149	2	,	,	PUNCT
admet-2214	149	3	pharmaceuticals	pharmaceutical	VERB
admet-2214	149	4	that	that	PRON
admet-2214	149	5	repel	repel	NOUN
admet-2214	149	6	water	water	NOUN
admet-2214	149	7	are	be	AUX
admet-2214	149	8	enclosed	enclose	VERB
admet-2214	149	9	within	within	ADP
admet-2214	149	10	the	the	DET
admet-2214	149	11	fatty	fatty	NOUN
admet-2214	149	12	layers	layer	NOUN
admet-2214	149	13	of	of	ADP
admet-2214	149	14	the	the	DET
admet-2214	149	15	outer	outer	ADJ
admet-2214	149	16	shell	shell	NOUN
admet-2214	149	17	,	,	PUNCT
admet-2214	149	18	whereas	whereas	SCONJ
admet-2214	149	19	drugs	drug	NOUN
admet-2214	149	20	that	that	PRON
admet-2214	149	21	dissolve	dissolve	VERB
admet-2214	149	22	in	in	ADP
admet-2214	149	23	water	water	NOUN
admet-2214	149	24	are	be	AUX
admet-2214	149	25	retained	retain	VERB
admet-2214	149	26	within	within	ADP
admet-2214	149	27	the	the	DET
admet-2214	149	28	watery	watery	ADJ
admet-2214	149	29	part	part	NOUN
admet-2214	149	30	of	of	ADP
admet-2214	149	31	the	the	DET
admet-2214	149	32	inner	inner	ADJ
admet-2214	149	33	core	core	NOUN
admet-2214	149	34	[	[	X
admet-2214	149	35	59,60	59,60	NUM
admet-2214	149	36	]	]	PUNCT
admet-2214	149	37	.	.	PUNCT
admet-2214	150	1	in	in	ADP
admet-2214	150	2	the	the	DET
admet-2214	150	3	realm	realm	NOUN
admet-2214	150	4	of	of	ADP
admet-2214	150	5	liposome	liposome	NOUN
admet-2214	150	6	preparation	preparation	NOUN
admet-2214	150	7	,	,	PUNCT
admet-2214	150	8	a	a	DET
admet-2214	150	9	multitude	multitude	NOUN
admet-2214	150	10	of	of	ADP
admet-2214	150	11	techniques	technique	NOUN
admet-2214	150	12	have	have	AUX
admet-2214	150	13	been	be	AUX
admet-2214	150	14	employed	employ	VERB
admet-2214	150	15	.	.	PUNCT
admet-2214	151	1	these	these	PRON
admet-2214	151	2	include	include	VERB
admet-2214	151	3	mechanical	mechanical	ADJ
admet-2214	151	4	dispersion	dispersion	NOUN
admet-2214	151	5	,	,	PUNCT
admet-2214	151	6	solvent	solvent	ADJ
admet-2214	151	7	dispersion	dispersion	NOUN
admet-2214	151	8	,	,	PUNCT
admet-2214	151	9	detergent	detergent	NOUN
admet-2214	151	10	removal	removal	NOUN
admet-2214	151	11	,	,	PUNCT
admet-2214	151	12	sonication	sonication	NOUN
admet-2214	151	13	,	,	PUNCT
admet-2214	151	14	french	french	ADJ
admet-2214	151	15	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	151	16	z.	z.	PROPN
admet-2214	151	17	presswala	presswala	PROPN
admet-2214	151	18	et	et	PROPN
admet-2214	151	19	al	al	PROPN
admet-2214	151	20	.	.	PROPN
admet-2214	151	21	admet	admet	PROPN
admet-2214	151	22	&	&	CCONJ
admet-2214	151	23	dmpk	dmpk	PROPN
admet-2214	151	24	12(3	12(3	PROPN
admet-2214	151	25	)	)	PUNCT
admet-2214	151	26	(	(	PUNCT
admet-2214	151	27	2024	2024	NUM
admet-2214	151	28	)	)	PUNCT
admet-2214	151	29	403	403	NUM
admet-2214	151	30	-	-	SYM
admet-2214	151	31	429	429	NUM
admet-2214	151	32	412	412	NUM
admet-2214	151	33	pressure	pressure	NOUN
admet-2214	151	34	cell	cell	NOUN
admet-2214	151	35	(	(	PUNCT
admet-2214	151	36	extrusion	extrusion	NOUN
admet-2214	151	37	)	)	PUNCT
admet-2214	151	38	,	,	PUNCT
admet-2214	151	39	freeze	freeze	VERB
admet-2214	151	40	drying	drying	NOUN
admet-2214	151	41	,	,	PUNCT
admet-2214	151	42	micro	micro	NOUN
admet-2214	151	43	-	-	NOUN
admet-2214	151	44	emulsification	emulsification	NOUN
admet-2214	151	45	,	,	PUNCT
admet-2214	151	46	membrane	membrane	NOUN
admet-2214	151	47	extrusion	extrusion	NOUN
admet-2214	151	48	,	,	PUNCT
admet-2214	151	49	and	and	CCONJ
admet-2214	151	50	dried	dry	VERB
admet-2214	151	51	reconstituted	reconstitute	VERB
admet-2214	151	52	vesicles	vesicle	NOUN
admet-2214	151	53	[	[	X
admet-2214	151	54	61	61	NUM
admet-2214	151	55	-	-	SYM
admet-2214	151	56	63	63	NUM
admet-2214	151	57	]	]	PUNCT
admet-2214	151	58	.	.	PUNCT
admet-2214	152	1	the	the	DET
admet-2214	152	2	table	table	NOUN
admet-2214	152	3	presented	present	VERB
admet-2214	152	4	herein	herein	NOUN
admet-2214	152	5	offers	offer	VERB
admet-2214	152	6	a	a	DET
admet-2214	152	7	comprehensive	comprehensive	ADJ
admet-2214	152	8	summary	summary	NOUN
admet-2214	152	9	of	of	ADP
admet-2214	152	10	preclinical	preclinical	ADJ
admet-2214	152	11	investigations	investigation	NOUN
admet-2214	152	12	centered	center	VERB
admet-2214	152	13	around	around	ADP
admet-2214	152	14	the	the	DET
admet-2214	152	15	utilization	utilization	NOUN
admet-2214	152	16	of	of	ADP
admet-2214	152	17	liposomes	liposome	NOUN
admet-2214	152	18	in	in	ADP
admet-2214	152	19	the	the	DET
admet-2214	152	20	context	context	NOUN
admet-2214	152	21	of	of	ADP
admet-2214	152	22	diffuse	diffuse	PROPN
admet-2214	152	23	intrinsic	intrinsic	ADJ
admet-2214	152	24	pontine	pontine	ADJ
admet-2214	152	25	glioma	glioma	NOUN
admet-2214	152	26	(	(	PUNCT
admet-2214	152	27	dipg	dipg	PROPN
admet-2214	152	28	)	)	PUNCT
admet-2214	152	29	.	.	PUNCT
admet-2214	153	1	these	these	DET
admet-2214	153	2	studies	study	NOUN
admet-2214	153	3	aim	aim	VERB
admet-2214	153	4	to	to	PART
admet-2214	153	5	elucidate	elucidate	VERB
admet-2214	153	6	the	the	DET
admet-2214	153	7	potential	potential	ADJ
admet-2214	153	8	therapeutic	therapeutic	ADJ
admet-2214	153	9	interventions	intervention	NOUN
admet-2214	153	10	and	and	CCONJ
admet-2214	153	11	advancements	advancement	NOUN
admet-2214	153	12	in	in	ADP
admet-2214	153	13	the	the	DET
admet-2214	153	14	field	field	NOUN
admet-2214	153	15	of	of	ADP
admet-2214	153	16	dipg	dipg	PROPN
admet-2214	153	17	research	research	NOUN
admet-2214	153	18	,	,	PUNCT
admet-2214	153	19	thereby	thereby	ADV
admet-2214	153	20	shedding	shed	VERB
admet-2214	153	21	light	light	NOUN
admet-2214	153	22	on	on	ADP
admet-2214	153	23	this	this	DET
admet-2214	153	24	intriguing	intriguing	ADJ
admet-2214	153	25	area	area	NOUN
admet-2214	153	26	of	of	ADP
admet-2214	153	27	study	study	NOUN
admet-2214	153	28	.	.	PUNCT
admet-2214	154	1	preclinical	preclinical	ADJ
admet-2214	154	2	studies	study	NOUN
admet-2214	154	3	of	of	ADP
admet-2214	154	4	liposomes	liposome	NOUN
admet-2214	154	5	in	in	ADP
admet-2214	154	6	dipg	dipg	NOUN
admet-2214	154	7	have	have	AUX
admet-2214	154	8	been	be	AUX
admet-2214	154	9	illustrated	illustrate	VERB
admet-2214	154	10	in	in	ADP
admet-2214	154	11	table	table	NOUN
admet-2214	154	12	2	2	NUM
admet-2214	154	13	.	.	PUNCT
admet-2214	154	14	table	table	NOUN
admet-2214	154	15	2	2	NUM
admet-2214	154	16	.	.	PUNCT
admet-2214	154	17	preclinical	preclinical	ADJ
admet-2214	154	18	studies	study	NOUN
admet-2214	154	19	of	of	ADP
admet-2214	154	20	liposomes	liposome	NOUN
admet-2214	154	21	in	in	ADP
admet-2214	154	22	dipg	dipg	PROPN
admet-2214	154	23	drug	drug	NOUN
admet-2214	154	24	formulation	formulation	NOUN
admet-2214	154	25	excipients	excipient	NOUN
admet-2214	154	26	overview	overview	VERB
admet-2214	154	27	method	method	NOUN
admet-2214	154	28	of	of	ADP
admet-2214	154	29	preparation	preparation	NOUN
admet-2214	154	30	evaluation	evaluation	NOUN
admet-2214	154	31	parameters	parameter	NOUN
admet-2214	154	32	outcome	outcome	VERB
admet-2214	154	33	docetaxel	docetaxel	NOUN
admet-2214	155	1	[	[	X
admet-2214	155	2	64,65	64,65	NOUN
admet-2214	155	3	]	]	X
admet-2214	155	4	gold	gold	NOUN
admet-2214	155	5	liposomes	liposome	NOUN
admet-2214	155	6	via	via	ADP
admet-2214	155	7	intravenous	intravenous	ADJ
admet-2214	155	8	route	route	NOUN
admet-2214	155	9	glutathione	glutathione	NOUN
admet-2214	155	10	,	,	PUNCT
admet-2214	155	11	transferrin	transferrin	NOUN
admet-2214	155	12	,	,	PUNCT
admet-2214	155	13	cholesterol	cholesterol	NOUN
admet-2214	155	14	,	,	PUNCT
admet-2214	155	15	egg	egg	NOUN
admet-2214	155	16	phosphatidylcho	phosphatidylcho	ADJ
admet-2214	155	17	line	line	NOUN
admet-2214	155	18	,	,	PUNCT
admet-2214	155	19	vitamin	vitamin	NOUN
admet-2214	155	20	e	e	NOUN
admet-2214	155	21	the	the	DET
admet-2214	155	22	goal	goal	NOUN
admet-2214	155	23	of	of	ADP
admet-2214	155	24	this	this	DET
admet-2214	155	25	research	research	NOUN
admet-2214	155	26	was	be	AUX
admet-2214	155	27	to	to	PART
admet-2214	155	28	create	create	VERB
admet-2214	155	29	gold	gold	NOUN
admet-2214	155	30	-	-	PUNCT
admet-2214	155	31	based	base	VERB
admet-2214	155	32	theranostic	theranostic	ADJ
admet-2214	155	33	liposomes	liposome	NOUN
admet-2214	155	34	that	that	PRON
admet-2214	155	35	target	target	VERB
admet-2214	155	36	the	the	DET
admet-2214	155	37	transferrin	transferrin	NOUN
admet-2214	155	38	(	(	PUNCT
admet-2214	155	39	tf	tf	X
admet-2214	155	40	)	)	PUNCT
admet-2214	155	41	receptor	receptor	NOUN
admet-2214	155	42	containing	contain	VERB
admet-2214	155	43	docetaxel	docetaxel	NOUN
admet-2214	155	44	(	(	PUNCT
admet-2214	155	45	dcx	dcx	PROPN
admet-2214	155	46	)	)	PUNCT
admet-2214	155	47	and	and	CCONJ
admet-2214	155	48	glutathione	glutathione	NOUN
admet-2214	155	49	(	(	PUNCT
admet-2214	155	50	augsh	augsh	NOUN
admet-2214	155	51	)	)	PUNCT
admet-2214	155	52	.	.	PUNCT
admet-2214	156	1	the	the	DET
admet-2214	156	2	carboxylated	carboxylate	VERB
admet-2214	156	3	vit	vit	NOUN
admet-2214	156	4	-	-	PUNCT
admet-2214	156	5	e	e	ADJ
admet-2214	156	6	tpgs	tpgs	NOUN
admet-2214	156	7	(	(	PUNCT
admet-2214	156	8	tpgs	tpgs	NOUN
admet-2214	156	9	-	-	PUNCT
admet-2214	156	10	cooh	cooh	NOUN
admet-2214	156	11	)	)	PUNCT
admet-2214	156	12	was	be	AUX
admet-2214	156	13	used	use	VERB
admet-2214	156	14	as	as	ADP
admet-2214	156	15	linker	linker	NOUN
admet-2214	156	16	.	.	PUNCT
admet-2214	157	1	using	use	VERB
admet-2214	157	2	the	the	DET
admet-2214	157	3	solvent	solvent	ADJ
admet-2214	157	4	injection	injection	NOUN
admet-2214	157	5	technique	technique	NOUN
admet-2214	157	6	,	,	PUNCT
admet-2214	157	7	a	a	DET
admet-2214	157	8	therapeutic	therapeutic	ADJ
admet-2214	157	9	agent	agent	NOUN
admet-2214	157	10	(	(	PUNCT
admet-2214	157	11	dcx	dcx	PROPN
admet-2214	157	12	)	)	PUNCT
admet-2214	157	13	and	and	CCONJ
admet-2214	157	14	a	a	DET
admet-2214	157	15	diagnostic	diagnostic	ADJ
admet-2214	157	16	agent	agent	NOUN
admet-2214	157	17	(	(	PUNCT
admet-2214	157	18	augsh	augsh	NOUN
admet-2214	157	19	)	)	PUNCT
admet-2214	157	20	were	be	AUX
admet-2214	157	21	added	add	VERB
admet-2214	157	22	to	to	ADP
admet-2214	157	23	the	the	DET
admet-2214	157	24	lipophilic	lipophilic	ADJ
admet-2214	157	25	bilayer	bilayer	NOUN
admet-2214	157	26	and	and	CCONJ
admet-2214	157	27	core	core	NOUN
admet-2214	157	28	of	of	ADP
admet-2214	157	29	liposomes	liposome	NOUN
admet-2214	157	30	,	,	PUNCT
admet-2214	157	31	respectively	respectively	ADV
admet-2214	157	32	.	.	PUNCT
admet-2214	158	1	additionally	additionally	ADV
admet-2214	158	2	,	,	PUNCT
admet-2214	158	3	gold	gold	NOUN
admet-2214	158	4	liposomes	liposome	NOUN
admet-2214	158	5	were	be	AUX
admet-2214	158	6	decorated	decorate	VERB
admet-2214	158	7	with	with	ADP
admet-2214	158	8	tf	tf	PROPN
admet-2214	158	9	.	.	PUNCT
admet-2214	158	10	tem	tem	PROPN
admet-2214	158	11	,	,	PUNCT
admet-2214	158	12	ftir	ftir	PROPN
admet-2214	158	13	,	,	PUNCT
admet-2214	158	14	nmr	nmr	NOUN
admet-2214	158	15	,	,	PUNCT
admet-2214	158	16	particle	particle	NOUN
admet-2214	158	17	size	size	NOUN
admet-2214	158	18	,	,	PUNCT
admet-2214	158	19	pdi	pdi	X
admet-2214	158	20	in	in	ADP
admet-2214	158	21	vitro	vitro	X
admet-2214	158	22	cytotoxicity	cytotoxicity	NOUN
admet-2214	158	23	,	,	PUNCT
admet-2214	158	24	atomic	atomic	ADJ
admet-2214	158	25	force	force	NOUN
admet-2214	158	26	microscopy	microscopy	NOUN
admet-2214	158	27	.	.	PUNCT
admet-2214	159	1	drug	drug	NOUN
admet-2214	159	2	encapsulation	encapsulation	NOUN
admet-2214	159	3	.	.	PUNCT
admet-2214	160	1	in	in	ADP
admet-2214	160	2	vitro	vitro	X
admet-2214	160	3	cellular	cellular	ADJ
admet-2214	160	4	uptake	uptake	ADJ
admet-2214	160	5	study	study	NOUN
admet-2214	160	6	the	the	DET
admet-2214	160	7	results	result	NOUN
admet-2214	160	8	of	of	ADP
admet-2214	160	9	these	these	DET
admet-2214	160	10	investigations	investigation	NOUN
admet-2214	160	11	suggest	suggest	VERB
admet-2214	160	12	that	that	SCONJ
admet-2214	160	13	tf	tf	PROPN
admet-2214	160	14	coated	coat	VERB
admet-2214	160	15	liposomes	liposome	NOUN
admet-2214	160	16	loaded	load	VERB
admet-2214	160	17	with	with	ADP
admet-2214	160	18	dc	dc	PROPN
admet-2214	160	19	and	and	CCONJ
admet-2214	160	20	angsh	angsh	NOUN
admet-2214	160	21	could	could	AUX
admet-2214	160	22	be	be	AUX
admet-2214	160	23	a	a	DET
admet-2214	160	24	useful	useful	ADJ
admet-2214	160	25	platform	platform	NOUN
admet-2214	160	26	for	for	ADP
admet-2214	160	27	customised	customised	ADJ
admet-2214	160	28	nano	nano	NOUN
admet-2214	160	29	-	-	PUNCT
admet-2214	160	30	theranostics	theranostic	NOUN
admet-2214	160	31	.	.	PUNCT
admet-2214	161	1	a	a	DET
admet-2214	161	2	medication	medication	NOUN
admet-2214	161	3	loading	loading	NOUN
admet-2214	161	4	level	level	NOUN
admet-2214	161	5	of	of	ADP
admet-2214	161	6	around	around	ADP
admet-2214	161	7	70	70	NUM
admet-2214	161	8	%	%	NOUN
admet-2214	161	9	was	be	AUX
admet-2214	161	10	reached	reach	VERB
admet-2214	161	11	for	for	ADP
admet-2214	161	12	both	both	DET
admet-2214	161	13	nano	nano	NOUN
admet-2214	161	14	formulations	formulation	NOUN
admet-2214	161	15	.	.	PUNCT
admet-2214	162	1	docotexal	docotexal	NOUN
admet-2214	163	1	[	[	X
admet-2214	163	2	66	66	NUM
admet-2214	163	3	]	]	X
admet-2214	163	4	liposomes	liposome	NOUN
admet-2214	163	5	via	via	ADP
admet-2214	163	6	intravenous	intravenous	ADJ
admet-2214	163	7	route	route	PROPN
admet-2214	163	8	transferrin	transferrin	NOUN
admet-2214	163	9	d	d	PROPN
admet-2214	163	10	-	-	PUNCT
admet-2214	163	11	alphatocopheryl	alphatocopheryl	ADJ
admet-2214	163	12	polyethylene	polyethylene	NOUN
admet-2214	163	13	glycol	glycol	NOUN
admet-2214	163	14	1000	1000	NUM
admet-2214	163	15	succinate	succinate	NOUN
admet-2214	163	16	mono	mono	NOUN
admet-2214	163	17	-	-	PUNCT
admet-2214	163	18	ester	ester	NOUN
admet-2214	163	19	(	(	PUNCT
admet-2214	163	20	tpgs	tpgs	NOUN
admet-2214	163	21	)	)	PUNCT
admet-2214	163	22	,	,	PUNCT
admet-2214	163	23	cholesterol	cholesterol	VERB
admet-2214	163	24	the	the	DET
admet-2214	163	25	creation	creation	NOUN
admet-2214	163	26	of	of	ADP
admet-2214	163	27	transferrin	transferrin	NOUN
admet-2214	163	28	conjugated	conjugate	VERB
admet-2214	163	29	tpgscoated	tpgscoate	VERB
admet-2214	163	30	theronostic	theronostic	ADJ
admet-2214	163	31	liposomes	liposome	NOUN
admet-2214	163	32	for	for	ADP
admet-2214	163	33	brain	brain	NOUN
admet-2214	163	34	cancer	cancer	NOUN
admet-2214	163	35	imaging	imaging	NOUN
admet-2214	163	36	and	and	CCONJ
admet-2214	163	37	treatment	treatment	NOUN
admet-2214	163	38	was	be	AUX
admet-2214	163	39	the	the	DET
admet-2214	163	40	goal	goal	NOUN
admet-2214	163	41	of	of	ADP
admet-2214	163	42	this	this	DET
admet-2214	163	43	study	study	NOUN
admet-2214	163	44	.	.	PUNCT
admet-2214	164	1	solvent	solvent	ADJ
admet-2214	164	2	injection	injection	NOUN
admet-2214	164	3	method	method	NOUN
admet-2214	164	4	particle	particle	NOUN
admet-2214	164	5	size	size	NOUN
admet-2214	164	6	,	,	PUNCT
admet-2214	164	7	polydispersity	polydispersity	NOUN
admet-2214	164	8	,	,	PUNCT
admet-2214	164	9	morphology	morphology	NOUN
admet-2214	164	10	,	,	PUNCT
admet-2214	164	11	drug	drug	NOUN
admet-2214	164	12	encapsulation	encapsulation	NOUN
admet-2214	164	13	efficiency	efficiency	NOUN
admet-2214	164	14	,	,	PUNCT
admet-2214	164	15	in	in	ADP
admet-2214	164	16	-	-	PUNCT
admet-2214	164	17	vitro	vitro	X
admet-2214	164	18	release	release	NOUN
admet-2214	164	19	study	study	NOUN
admet-2214	164	20	and	and	CCONJ
admet-2214	164	21	brain	brain	NOUN
admet-2214	164	22	theranostic	theranostic	ADJ
admet-2214	164	23	,	,	PUNCT
admet-2214	164	24	in	in	ADP
admet-2214	164	25	vivo	vivo	NOUN
admet-2214	164	26	study	study	NOUN
admet-2214	164	27	methotrexate	methotrexate	NOUN
admet-2214	165	1	[	[	X
admet-2214	165	2	67,68	67,68	NOUN
admet-2214	165	3	]	]	X
admet-2214	165	4	liposomes	liposome	NOUN
admet-2214	165	5	via	via	ADP
admet-2214	165	6	intravenous	intravenous	ADJ
admet-2214	165	7	route	route	NOUN
admet-2214	165	8	hydrogenated	hydrogenate	VERB
admet-2214	165	9	soy	soy	NOUN
admet-2214	165	10	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2214	165	11	(	(	PUNCT
admet-2214	165	12	hspc	hspc	NOUN
admet-2214	165	13	)	)	PUNCT
admet-2214	165	14	,	,	PUNCT
admet-2214	165	15	egg	egg	NOUN
admet-2214	165	16	-	-	PUNCT
admet-2214	165	17	yolk	yolk	NOUN
admet-2214	165	18	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2214	165	19	(	(	PUNCT
admet-2214	165	20	eypc	eypc	PROPN
admet-2214	165	21	)	)	PUNCT
admet-2214	165	22	,	,	PUNCT
admet-2214	165	23	and	and	CCONJ
admet-2214	165	24	1,2	1,2	NUM
admet-2214	165	25	-	-	PUNCT
admet-2214	165	26	distearoylsn	distearoylsn	NOUN
admet-2214	165	27	-	-	PUNCT
admet-2214	165	28	glycero-3	glycero-3	NOUN
admet-2214	165	29	-	-	PUNCT
admet-2214	165	30	phosphoethanolamineconjugated	phosphoethanolamineconjugate	VERB
admet-2214	165	31	polyethylene	polyethylene	NOUN
admet-2214	165	32	glycol	glycol	NOUN
admet-2214	165	33	mw	mw	VERB
admet-2214	165	34	2000	2000	NUM
admet-2214	165	35	(	(	PUNCT
admet-2214	165	36	mpegdspe	mpegdspe	PROPN
admet-2214	165	37	)	)	PUNCT
admet-2214	165	38	,	,	PUNCT
admet-2214	165	39	cholesterol	cholesterol	NOUN
admet-2214	165	40	,	,	PUNCT
admet-2214	165	41	acetonitrile	acetonitrile	NOUN
admet-2214	165	42	,	,	PUNCT
admet-2214	165	43	methanol	methanol	NOUN
admet-2214	165	44	and	and	CCONJ
admet-2214	165	45	formic	formic	ADJ
admet-2214	165	46	acid	acid	PROPN
admet-2214	165	47	this	this	DET
admet-2214	165	48	study	study	NOUN
admet-2214	165	49	involved	involve	VERB
admet-2214	165	50	quantitative	quantitative	ADJ
admet-2214	165	51	evaluation	evaluation	NOUN
admet-2214	165	52	of	of	ADP
admet-2214	165	53	the	the	DET
admet-2214	165	54	effects	effect	NOUN
admet-2214	165	55	of	of	ADP
admet-2214	165	56	liposome	liposome	NOUN
admet-2214	165	57	formulations	formulation	NOUN
admet-2214	165	58	on	on	ADP
admet-2214	165	59	the	the	DET
admet-2214	165	60	in	in	ADP
admet-2214	165	61	vivo	vivo	ADJ
admet-2214	165	62	release	release	NOUN
admet-2214	165	63	and	and	CCONJ
admet-2214	165	64	brain	brain	NOUN
admet-2214	165	65	delivery	delivery	NOUN
admet-2214	165	66	of	of	ADP
admet-2214	165	67	methotrexate	methotrexate	NOUN
admet-2214	165	68	(	(	PUNCT
admet-2214	165	69	mtx	mtx	NOUN
admet-2214	165	70	)	)	PUNCT
admet-2214	165	71	in	in	ADP
admet-2214	165	72	rats	rat	NOUN
admet-2214	165	73	.	.	PUNCT
admet-2214	166	1	on	on	ADP
admet-2214	166	2	the	the	DET
admet-2214	166	3	basis	basis	NOUN
admet-2214	166	4	of	of	ADP
admet-2214	166	5	egg	egg	NOUN
admet-2214	166	6	-	-	PUNCT
admet-2214	166	7	yolk	yolk	NOUN
admet-2214	166	8	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2214	166	9	(	(	PUNCT
admet-2214	166	10	eypc	eypc	PROPN
admet-2214	166	11	)	)	PUNCT
admet-2214	166	12	or	or	CCONJ
admet-2214	166	13	hydrogenated	hydrogenate	VERB
admet-2214	166	14	soy	soy	NOUN
admet-2214	166	15	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2214	166	16	(	(	PUNCT
admet-2214	166	17	hspc	hspc	PROPN
admet-2214	166	18	)	)	PUNCT
admet-2214	166	19	,	,	PUNCT
admet-2214	166	20	two	two	NUM
admet-2214	166	21	pegylated	pegylate	VERB
admet-2214	166	22	liposomal	liposomal	ADJ
admet-2214	166	23	mtx	mtx	NOUN
admet-2214	166	24	formulations	formulation	NOUN
admet-2214	166	25	were	be	AUX
admet-2214	166	26	created	create	VERB
admet-2214	166	27	.	.	PUNCT
admet-2214	167	1	by	by	ADP
admet-2214	167	2	measuring	measure	VERB
admet-2214	167	3	the	the	DET
admet-2214	167	4	released	release	VERB
admet-2214	167	5	,	,	PUNCT
admet-2214	167	6	unbound	unbound	PROPN
admet-2214	167	7	mtx	mtx	NOUN
admet-2214	167	8	in	in	ADP
admet-2214	167	9	brain	brain	NOUN
admet-2214	167	10	and	and	CCONJ
admet-2214	167	11	plasma	plasma	NOUN
admet-2214	167	12	using	use	VERB
admet-2214	167	13	microdialysis	microdialysis	NOUN
admet-2214	167	14	,	,	PUNCT
admet-2214	167	15	the	the	DET
admet-2214	167	16	drug	drug	NOUN
admet-2214	167	17	release	release	NOUN
admet-2214	167	18	and	and	CCONJ
admet-2214	167	19	uptake	uptake	ADJ
admet-2214	167	20	into	into	ADP
admet-2214	167	21	the	the	DET
admet-2214	167	22	brain	brain	NOUN
admet-2214	167	23	following	follow	VERB
admet-2214	167	24	intravenous	intravenous	ADJ
admet-2214	167	25	administration	administration	NOUN
admet-2214	167	26	of	of	ADP
admet-2214	167	27	both	both	DET
admet-2214	167	28	formulations	formulation	NOUN
admet-2214	167	29	were	be	AUX
admet-2214	167	30	compared	compare	VERB
admet-2214	167	31	to	to	ADP
admet-2214	167	32	unformulated	unformulated	ADJ
admet-2214	167	33	mtx	mtx	NOUN
admet-2214	167	34	.	.	PUNCT
admet-2214	168	1	the	the	DET
admet-2214	168	2	ethanol	ethanol	NOUN
admet-2214	168	3	injection	injection	NOUN
admet-2214	168	4	method	method	NOUN
admet-2214	168	5	,	,	PUNCT
admet-2214	168	6	which	which	PRON
admet-2214	168	7	involves	involve	VERB
admet-2214	168	8	the	the	DET
admet-2214	168	9	preinsertion	preinsertion	NOUN
admet-2214	168	10	of	of	ADP
admet-2214	168	11	peg	peg	NOUN
admet-2214	168	12	lipid	lipid	NOUN
admet-2214	168	13	,	,	PUNCT
admet-2214	168	14	is	be	AUX
admet-2214	168	15	a	a	DET
admet-2214	168	16	notable	notable	ADJ
admet-2214	168	17	technique	technique	NOUN
admet-2214	168	18	in	in	ADP
admet-2214	168	19	the	the	DET
admet-2214	168	20	field	field	NOUN
admet-2214	168	21	.	.	PUNCT
admet-2214	169	1	liposome	liposome	VERB
admet-2214	169	2	stability	stability	NOUN
admet-2214	169	3	study	study	NOUN
admet-2214	169	4	in	in	ADP
admet-2214	169	5	vitro	vitro	NOUN
admet-2214	169	6	,	,	PUNCT
admet-2214	169	7	in	in	ADP
admet-2214	169	8	vivo	vivo	NOUN
admet-2214	169	9	micro	micro	NOUN
admet-2214	169	10	dialysis	dialysis	NOUN
admet-2214	169	11	,	,	PUNCT
admet-2214	169	12	size	size	NOUN
admet-2214	169	13	,	,	PUNCT
admet-2214	169	14	pdi	pdi	PROPN
admet-2214	169	15	,	,	PUNCT
admet-2214	169	16	ee	ee	PROPN
admet-2214	169	17	,	,	PUNCT
admet-2214	169	18	lipid	lipid	NOUN
admet-2214	169	19	levels	level	NOUN
admet-2214	169	20	,	,	PUNCT
admet-2214	169	21	the	the	DET
admet-2214	169	22	findings	finding	NOUN
admet-2214	169	23	presented	present	VERB
admet-2214	169	24	in	in	ADP
admet-2214	169	25	this	this	DET
admet-2214	169	26	study	study	NOUN
admet-2214	169	27	highlight	highlight	VERB
admet-2214	169	28	the	the	DET
admet-2214	169	29	significant	significant	ADJ
admet-2214	169	30	influence	influence	NOUN
admet-2214	169	31	of	of	ADP
admet-2214	169	32	the	the	DET
admet-2214	169	33	phospholipid	phospholipid	NOUN
admet-2214	169	34	used	use	VERB
admet-2214	169	35	in	in	ADP
admet-2214	169	36	the	the	DET
admet-2214	169	37	formulation	formulation	NOUN
admet-2214	169	38	of	of	ADP
admet-2214	169	39	pegylated	pegylated	ADJ
admet-2214	169	40	liposomes	liposome	NOUN
admet-2214	169	41	on	on	ADP
admet-2214	169	42	the	the	DET
admet-2214	169	43	in	in	ADP
admet-2214	169	44	vivo	vivo	ADJ
admet-2214	169	45	release	release	NOUN
admet-2214	169	46	and	and	CCONJ
admet-2214	169	47	brain	brain	NOUN
admet-2214	169	48	delivery	delivery	NOUN
admet-2214	169	49	of	of	ADP
admet-2214	169	50	mtx	mtx	NOUN
admet-2214	169	51	.	.	PUNCT
admet-2214	170	1	irinotecan	irinotecan	PROPN
admet-2214	170	2	s	s	PART
admet-2214	171	1	[	[	X
admet-2214	171	2	69,70	69,70	X
admet-2214	171	3	]	]	PUNCT
admet-2214	171	4	nanoliposomes	nanoliposome	NOUN
admet-2214	171	5	via	via	ADP
admet-2214	171	6	intranasal	intranasal	ADJ
admet-2214	171	7	route	route	NOUN
admet-2214	171	8	1,2	1,2	NUM
admet-2214	171	9	-	-	PUNCT
admet-2214	171	10	dioleoyl	dioleoyl	ADJ
admet-2214	171	11	-	-	PUNCT
admet-2214	171	12	sn	sn	NOUN
admet-2214	171	13	-	-	PUNCT
admet-2214	171	14	glycero-3	glycero-3	NOUN
admet-2214	171	15	-	-	PUNCT
admet-2214	171	16	phosphocholine	phosphocholine	NOUN
admet-2214	171	17	,	,	PUNCT
admet-2214	171	18	1ʹ,3ʹbis[1,2dioleoyl	1ʹ,3ʹbis[1,2dioleoyl	PROPN
admet-2214	171	19	-	-	PUNCT
admet-2214	171	20	snglycero-3	snglycero-3	NOUN
admet-2214	171	21	-	-	PUNCT
admet-2214	171	22	phospho]-glycerol	phospho]-glycerol	NOUN
admet-2214	171	23	,	,	PUNCT
admet-2214	171	24	cholesterol	cholesterol	NOUN
admet-2214	171	25	,	,	PUNCT
admet-2214	171	26	and	and	CCONJ
admet-2214	171	27	1,2	1,2	NUM
admet-2214	171	28	-	-	NOUN
admet-2214	171	29	dist	dist	NOUN
admet-2214	171	30	earoyl	earoyl	NOUN
admet-2214	171	31	-	-	PUNCT
admet-2214	171	32	snglycero-3	snglycero-3	NOUN
admet-2214	171	33	-	-	PUNCT
admet-2214	171	34	phosphoethanolamine	phosphoethanolamine	NOUN
admet-2214	171	35	-	-	PUNCT
admet-2214	171	36	n	n	NOUN
admet-2214	171	37	-[methoxy(polyethylene	-[methoxy(polyethylene	NOUN
admet-2214	171	38	glycol)-2000	glycol)-2000	PROPN
admet-2214	171	39	]	]	X
admet-2214	171	40	the	the	DET
admet-2214	171	41	effectiveness	effectiveness	NOUN
admet-2214	171	42	of	of	ADP
admet-2214	171	43	nanoliposomal	nanoliposomal	ADJ
admet-2214	171	44	(	(	PUNCT
admet-2214	171	45	ls	ls	ADJ
admet-2214	171	46	)	)	PUNCT
admet-2214	171	47	irinotecan	irinotecan	NOUN
admet-2214	171	48	(	(	PUNCT
admet-2214	171	49	cpt-11	cpt-11	NUM
admet-2214	171	50	)	)	PUNCT
admet-2214	171	51	and	and	CCONJ
admet-2214	171	52	its	its	PRON
admet-2214	171	53	active	active	ADJ
admet-2214	171	54	metabolite	metabolite	NOUN
admet-2214	171	55	,	,	PUNCT
admet-2214	171	56	7	7	NUM
admet-2214	171	57	-	-	PUNCT
admet-2214	171	58	ethyl10	ethyl10	NOUN
admet-2214	171	59	-	-	PUNCT
admet-2214	171	60	hydroxycamptothecin	hydroxycamptothecin	PROPN
admet-2214	171	61	(	(	PUNCT
admet-2214	171	62	sn-38	sn-38	NOUN
admet-2214	171	63	)	)	PUNCT
admet-2214	171	64	,	,	PUNCT
admet-2214	171	65	in	in	ADP
admet-2214	171	66	dipg	dipg	PROPN
admet-2214	171	67	patientderived	patientderive	VERB
admet-2214	171	68	xenograft	xenograft	NOUN
admet-2214	171	69	models	model	NOUN
admet-2214	171	70	was	be	AUX
admet-2214	171	71	examined	examine	VERB
admet-2214	171	72	in	in	ADP
admet-2214	171	73	this	this	DET
admet-2214	171	74	work	work	NOUN
admet-2214	171	75	.	.	PUNCT
admet-2214	172	1	thin	thin	ADJ
admet-2214	172	2	film	film	NOUN
admet-2214	172	3	hydration	hydration	NOUN
admet-2214	172	4	by	by	ADP
admet-2214	172	5	solvent	solvent	ADJ
admet-2214	172	6	rotary	rotary	NOUN
admet-2214	172	7	evaporator	evaporator	NOUN
admet-2214	172	8	.	.	PUNCT
admet-2214	173	1	final	final	ADJ
admet-2214	173	2	the	the	DET
admet-2214	173	3	solution	solution	NOUN
admet-2214	173	4	underwent	undergo	VERB
admet-2214	173	5	additional	additional	ADJ
admet-2214	173	6	homogenization	homogenization	NOUN
admet-2214	173	7	through	through	ADP
admet-2214	173	8	the	the	DET
admet-2214	173	9	use	use	NOUN
admet-2214	173	10	of	of	ADP
admet-2214	173	11	an	an	DET
admet-2214	173	12	ultrasonified	ultrasonified	ADJ
admet-2214	173	13	homogenizer	homogenizer	NOUN
admet-2214	173	14	.	.	PUNCT
admet-2214	174	1	cell	cell	NOUN
admet-2214	174	2	viability	viability	NOUN
admet-2214	174	3	and	and	CCONJ
admet-2214	174	4	colony	colony	NOUN
admet-2214	174	5	formation	formation	NOUN
admet-2214	174	6	assays	assay	NOUN
admet-2214	174	7	,	,	PUNCT
admet-2214	174	8	apoptosis	apoptosis	NOUN
admet-2214	174	9	assay	assay	NOUN
admet-2214	174	10	,	,	PUNCT
admet-2214	174	11	in	in	ADP
admet-2214	174	12	vitro	vitro	X
admet-2214	174	13	cellular	cellular	ADJ
admet-2214	174	14	uptake	uptake	NOUN
admet-2214	174	15	and	and	CCONJ
admet-2214	174	16	distribution	distribution	NOUN
admet-2214	174	17	,	,	PUNCT
admet-2214	174	18	xenograft	xenograft	NOUN
admet-2214	174	19	models	model	NOUN
admet-2214	174	20	,	,	PUNCT
admet-2214	174	21	analysis	analysis	NOUN
admet-2214	174	22	of	of	ADP
admet-2214	174	23	drug	drug	NOUN
admet-2214	174	24	concentration	concentration	NOUN
admet-2214	174	25	in	in	ADP
admet-2214	174	26	the	the	DET
admet-2214	174	27	brainstem	brainstem	NOUN
admet-2214	174	28	tumor	tumor	NOUN
admet-2214	174	29	,	,	PUNCT
admet-2214	174	30	in	in	ADP
admet-2214	174	31	vivo	vivo	NOUN
admet-2214	174	32	therapy	therapy	NOUN
admet-2214	174	33	response	response	NOUN
admet-2214	174	34	study	study	NOUN
admet-2214	174	35	,	,	PUNCT
admet-2214	174	36	immunohistochemistry	immunohistochemistry	NOUN
admet-2214	174	37	,	,	PUNCT
admet-2214	174	38	statistical	statistical	ADJ
admet-2214	174	39	analysis	analysis	NOUN
admet-2214	174	40	admet	admet	PROPN
admet-2214	174	41	&	&	CCONJ
admet-2214	174	42	dmpk	dmpk	PROPN
admet-2214	174	43	12(3	12(3	PROPN
admet-2214	174	44	)	)	PUNCT
admet-2214	174	45	(	(	PUNCT
admet-2214	174	46	2024	2024	NUM
admet-2214	174	47	)	)	PUNCT
admet-2214	174	48	403	403	NUM
admet-2214	174	49	-	-	SYM
admet-2214	174	50	429	429	NUM
admet-2214	174	51	addressing	address	VERB
admet-2214	174	52	barriers	barrier	NOUN
admet-2214	174	53	in	in	ADP
admet-2214	174	54	diffuse	diffuse	ADJ
admet-2214	174	55	intrinsic	intrinsic	ADJ
admet-2214	174	56	pontine	pontine	ADJ
admet-2214	174	57	glioma	glioma	NOUN
admet-2214	174	58	doi	doi	NOUN
admet-2214	174	59	:	:	PUNCT
admet-2214	174	60	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	174	61	413	413	NUM
admet-2214	174	62	drug	drug	NOUN
admet-2214	174	63	formulation	formulation	NOUN
admet-2214	174	64	excipients	excipient	NOUN
admet-2214	174	65	overview	overview	VERB
admet-2214	174	66	method	method	NOUN
admet-2214	174	67	of	of	ADP
admet-2214	174	68	preparation	preparation	NOUN
admet-2214	174	69	evaluation	evaluation	NOUN
admet-2214	174	70	parameters	parameter	NOUN
admet-2214	174	71	outcome	outcome	VERB
admet-2214	174	72	limonene	limonene	NOUN
admet-2214	175	1	[	[	X
admet-2214	175	2	71	71	NUM
admet-2214	175	3	]	]	X
admet-2214	175	4	liposomes	liposome	VERB
admet-2214	175	5	trypsin	trypsin	NOUN
admet-2214	175	6	-	-	PUNCT
admet-2214	175	7	edta	edta	NOUN
admet-2214	175	8	,	,	PUNCT
admet-2214	175	9	phosphate	phosphate	ADJ
admet-2214	175	10	buffer	buffer	NOUN
admet-2214	175	11	saline	saline	NOUN
admet-2214	175	12	(	(	PUNCT
admet-2214	175	13	pbs	pbs	PROPN
admet-2214	175	14	)	)	PUNCT
admet-2214	175	15	,	,	PUNCT
admet-2214	175	16	3-(4,5dimethylthiazol-2yl)-2,5	3-(4,5dimethylthiazol-2yl)-2,5	NUM
admet-2214	175	17	-	-	PUNCT
admet-2214	175	18	diphenyltetrazolium	diphenyltetrazolium	NOUN
admet-2214	175	19	bromide	bromide	NOUN
admet-2214	175	20	salt	salt	NOUN
admet-2214	175	21	,	,	PUNCT
admet-2214	175	22	dimethyl	dimethyl	NOUN
admet-2214	175	23	sulfoxide	sulfoxide	NOUN
admet-2214	175	24	.	.	PUNCT
admet-2214	176	1	this	this	DET
admet-2214	176	2	study	study	NOUN
admet-2214	176	3	set	set	VERB
admet-2214	176	4	out	out	ADP
admet-2214	176	5	to	to	PART
admet-2214	176	6	assess	assess	VERB
admet-2214	176	7	the	the	DET
admet-2214	176	8	effectiveness	effectiveness	NOUN
admet-2214	176	9	of	of	ADP
admet-2214	176	10	liposomes	liposome	NOUN
admet-2214	176	11	loaded	load	VERB
admet-2214	176	12	with	with	ADP
admet-2214	176	13	dlimonene	dlimonene	NOUN
admet-2214	176	14	on	on	ADP
admet-2214	176	15	u87	u87	NOUN
admet-2214	176	16	mg	mg	PROPN
admet-2214	176	17	cells	cell	NOUN
admet-2214	176	18	as	as	ADV
admet-2214	176	19	well	well	ADV
admet-2214	176	20	as	as	ADP
admet-2214	176	21	the	the	DET
admet-2214	176	22	signaling	signal	VERB
admet-2214	176	23	pathways	pathway	NOUN
admet-2214	176	24	connected	connect	VERB
admet-2214	176	25	to	to	ADP
admet-2214	176	26	cell	cell	NOUN
admet-2214	176	27	death	death	NOUN
admet-2214	176	28	.	.	PUNCT
admet-2214	177	1	not	not	PART
admet-2214	177	2	disclosed	disclose	VERB
admet-2214	177	3	not	not	PART
admet-2214	177	4	disclosed	disclose	VERB
admet-2214	177	5	the	the	DET
admet-2214	177	6	outcomes	outcome	NOUN
admet-2214	177	7	demonstrate	demonstrate	VERB
admet-2214	177	8	that	that	SCONJ
admet-2214	177	9	human	human	ADJ
admet-2214	177	10	embryonic	embryonic	ADJ
admet-2214	177	11	kidney	kidney	NOUN
admet-2214	177	12	(	(	PUNCT
admet-2214	177	13	hek293	hek293	PROPN
admet-2214	177	14	)	)	PUNCT
admet-2214	177	15	cells	cell	NOUN
admet-2214	177	16	were	be	AUX
admet-2214	177	17	not	not	PART
admet-2214	177	18	able	able	ADJ
admet-2214	177	19	to	to	PART
admet-2214	177	20	internalize	internalize	VERB
admet-2214	177	21	the	the	DET
admet-2214	177	22	drugloaded	drugloade	VERB
admet-2214	177	23	liposomes	liposome	NOUN
admet-2214	177	24	;	;	PUNCT
admet-2214	177	25	instead	instead	ADV
admet-2214	177	26	,	,	PUNCT
admet-2214	177	27	they	they	PRON
admet-2214	177	28	could	could	AUX
admet-2214	177	29	only	only	ADV
admet-2214	177	30	do	do	VERB
admet-2214	177	31	so	so	ADV
admet-2214	177	32	in	in	ADP
admet-2214	177	33	glioma	glioma	NOUN
admet-2214	177	34	(	(	PUNCT
admet-2214	177	35	u87	u87	NOUN
admet-2214	177	36	mg	mg	NOUN
admet-2214	177	37	)	)	PUNCT
admet-2214	177	38	cells	cell	NOUN
admet-2214	177	39	.	.	PUNCT
admet-2214	178	1	paclitaxel	paclitaxel	PROPN
admet-2214	178	2	,	,	PUNCT
admet-2214	178	3	berberine	berberine	NOUN
admet-2214	178	4	[	[	X
admet-2214	178	5	72	72	NUM
admet-2214	178	6	]	]	X
admet-2214	178	7	liposomes	liposome	VERB
admet-2214	178	8	folic	folic	ADJ
admet-2214	178	9	acid	acid	NOUN
admet-2214	178	10	,	,	PUNCT
admet-2214	178	11	tween	tween	NOUN
admet-2214	178	12	80	80	NUM
admet-2214	178	13	,	,	PUNCT
admet-2214	178	14	folic	folic	ADJ
admet-2214	178	15	acid	acid	NOUN
admet-2214	178	16	,	,	PUNCT
admet-2214	178	17	soybean	soybean	NOUN
admet-2214	178	18	phospholipids	phospholipid	NOUN
admet-2214	178	19	,	,	PUNCT
admet-2214	178	20	cholesterol	cholesterol	NOUN
admet-2214	178	21	.	.	PUNCT
admet-2214	179	1	a	a	DET
admet-2214	179	2	formulation	formulation	NOUN
admet-2214	179	3	that	that	PRON
admet-2214	179	4	is	be	AUX
admet-2214	179	5	both	both	CCONJ
admet-2214	179	6	intelligent	intelligent	ADJ
admet-2214	179	7	and	and	CCONJ
admet-2214	179	8	responsive	responsive	ADJ
admet-2214	179	9	to	to	ADP
admet-2214	179	10	the	the	DET
admet-2214	179	11	tumor	tumor	NOUN
admet-2214	179	12	microenvironment	microenvironment	NOUN
admet-2214	179	13	(	(	PUNCT
admet-2214	179	14	tme	tme	NOUN
admet-2214	179	15	)	)	PUNCT
admet-2214	179	16	using	use	VERB
admet-2214	179	17	folic	folic	ADJ
admet-2214	179	18	acid	acid	NOUN
admet-2214	179	19	(	(	PUNCT
admet-2214	179	20	fa	fa	NOUN
admet-2214	179	21	)	)	PUNCT
admet-2214	179	22	derivatives	derivative	NOUN
admet-2214	179	23	and	and	CCONJ
admet-2214	179	24	mitochondria	mitochondria	NOUN
admet-2214	179	25	was	be	AUX
admet-2214	179	26	created.ptx	created.ptx	X
admet-2214	179	27	-	-	PUNCT
admet-2214	179	28	tween	tween	ADJ
admet-2214	179	29	80bbr	80bbr	NOUN
admet-2214	179	30	+	+	CCONJ
admet-2214	179	31	fa	fa	NOUN
admet-2214	179	32	-	-	PUNCT
admet-2214	179	33	lip	lip	NOUN
admet-2214	179	34	,	,	PUNCT
admet-2214	179	35	a	a	DET
admet-2214	179	36	comodified	comodifie	VERB
admet-2214	179	37	liposome	liposome	NOUN
admet-2214	179	38	coated	coat	VERB
admet-2214	179	39	with	with	ADP
admet-2214	179	40	tween	tween	NOUN
admet-2214	179	41	80	80	NUM
admet-2214	179	42	that	that	PRON
admet-2214	179	43	targets	target	VERB
admet-2214	179	44	berberine	berberine	NOUN
admet-2214	179	45	(	(	PUNCT
admet-2214	179	46	bbr	bbr	PROPN
admet-2214	179	47	)	)	PUNCT
admet-2214	179	48	derivatives	derivative	NOUN
admet-2214	179	49	,	,	PUNCT
admet-2214	179	50	was	be	AUX
admet-2214	179	51	created	create	VERB
admet-2214	179	52	.	.	PUNCT
admet-2214	180	1	not	not	PART
admet-2214	180	2	disclosed	disclose	VERB
admet-2214	180	3	not	not	PART
admet-2214	180	4	disclosed	disclose	VERB
admet-2214	180	5	based	base	VERB
admet-2214	180	6	on	on	ADP
admet-2214	180	7	highly	highly	ADV
admet-2214	180	8	specific	specific	ADJ
admet-2214	180	9	tumor	tumor	NOUN
admet-2214	180	10	targeting	target	VERB
admet-2214	180	11	and	and	CCONJ
admet-2214	180	12	mitochondrial	mitochondrial	ADJ
admet-2214	180	13	targeting	targeting	NOUN
admet-2214	180	14	,	,	PUNCT
admet-2214	180	15	the	the	DET
admet-2214	180	16	results	result	NOUN
admet-2214	180	17	demonstrated	demonstrate	VERB
admet-2214	180	18	that	that	SCONJ
admet-2214	180	19	ptxtween	ptxtween	ADJ
admet-2214	180	20	80	80	NUM
admet-2214	180	21	-	-	PUNCT
admet-2214	180	22	bbr	bbr	NOUN
admet-2214	180	23	+	+	CCONJ
admet-2214	180	24	falip	falip	NOUN
admet-2214	180	25	can	can	AUX
admet-2214	180	26	observably	observably	ADV
admet-2214	180	27	improve	improve	VERB
admet-2214	180	28	the	the	DET
admet-2214	180	29	therapeutic	therapeutic	ADJ
admet-2214	180	30	efficacy	efficacy	NOUN
admet-2214	180	31	of	of	ADP
admet-2214	180	32	chemotherapy	chemotherapy	NOUN
admet-2214	180	33	.	.	PUNCT
admet-2214	181	1	this	this	PRON
admet-2214	181	2	can	can	AUX
admet-2214	181	3	lead	lead	VERB
admet-2214	181	4	to	to	ADP
admet-2214	181	5	new	new	ADJ
admet-2214	181	6	concepts	concept	NOUN
admet-2214	181	7	and	and	CCONJ
admet-2214	181	8	approaches	approach	NOUN
admet-2214	181	9	for	for	ADP
admet-2214	181	10	the	the	DET
admet-2214	181	11	targeted	target	VERB
admet-2214	181	12	therapy	therapy	NOUN
admet-2214	181	13	of	of	ADP
admet-2214	181	14	gliomas	glioma	NOUN
admet-2214	181	15	.	.	PUNCT
admet-2214	182	1	octarginine	octarginine	NOUN
admet-2214	183	1	[	[	X
admet-2214	183	2	73	73	NUM
admet-2214	183	3	]	]	PUNCT
admet-2214	183	4	liposomes	liposome	VERB
admet-2214	183	5	1,2	1,2	NUM
admet-2214	183	6	-	-	PUNCT
admet-2214	183	7	distearoyl	distearoyl	NOUN
admet-2214	183	8	-	-	PUNCT
admet-2214	183	9	snglycero-3	snglycero-3	NOUN
admet-2214	183	10	-	-	PUNCT
admet-2214	183	11	phosphocholine	phosphocholine	NOUN
admet-2214	183	12	,	,	PUNCT
admet-2214	183	13	rhodamine1,2	rhodamine1,2	PROPN
admet-2214	183	14	-	-	PUNCT
admet-2214	183	15	dioleoyl	dioleoyl	ADJ
admet-2214	183	16	-	-	PUNCT
admet-2214	183	17	snglycero-3	snglycero-3	NOUN
admet-2214	183	18	-	-	PUNCT
admet-2214	183	19	phosphoethanolamine	phosphoethanolamine	NOUN
admet-2214	183	20	-	-	PUNCT
admet-2214	183	21	n	n	CCONJ
admet-2214	183	22	,	,	PUNCT
admet-2214	183	23	peg2k	peg2k	PROPN
admet-2214	183	24	-	-	PUNCT
admet-2214	183	25	dspe	dspe	PROPN
admet-2214	183	26	.	.	PUNCT
admet-2214	184	1	the	the	DET
admet-2214	184	2	current	current	ADJ
admet-2214	184	3	study	study	NOUN
admet-2214	184	4	aims	aim	VERB
admet-2214	184	5	to	to	PART
admet-2214	184	6	create	create	VERB
admet-2214	184	7	new	new	ADJ
admet-2214	184	8	pegylated	pegylate	VERB
admet-2214	184	9	liposomes	liposome	NOUN
admet-2214	184	10	grafted	graft	VERB
admet-2214	184	11	with	with	ADP
admet-2214	184	12	octaarginine	octaarginine	NOUN
admet-2214	184	13	(	(	PUNCT
admet-2214	184	14	r8	r8	NOUN
admet-2214	184	15	)	)	PUNCT
admet-2214	184	16	peptidehfq	peptidehfq	NOUN
admet-2214	184	17	lipid	lipid	NOUN
admet-2214	184	18	for	for	ADP
admet-2214	184	19	targeting	target	VERB
admet-2214	184	20	glioma	glioma	NOUN
admet-2214	184	21	cells	cell	NOUN
admet-2214	184	22	.	.	PUNCT
admet-2214	185	1	not	not	PART
admet-2214	185	2	disclosed	disclose	VERB
admet-2214	185	3	particle	particle	NOUN
admet-2214	185	4	size	size	NOUN
admet-2214	185	5	,	,	PUNCT
admet-2214	185	6	zeta	zeta	NOUN
admet-2214	185	7	potential	potential	NOUN
admet-2214	185	8	and	and	CCONJ
admet-2214	185	9	polydispersity	polydispersity	NOUN
admet-2214	185	10	index	index	NOUN
admet-2214	185	11	tem	tem	PROPN
admet-2214	185	12	,	,	PUNCT
admet-2214	185	13	in	in	ADP
admet-2214	185	14	vitro	vitro	X
admet-2214	185	15	studies	study	NOUN
admet-2214	185	16	.	.	PUNCT
admet-2214	186	1	the	the	DET
admet-2214	186	2	study	study	NOUN
admet-2214	186	3	's	's	PART
admet-2214	186	4	findings	finding	NOUN
admet-2214	186	5	suggest	suggest	VERB
admet-2214	186	6	that	that	SCONJ
admet-2214	186	7	ligandhfq	ligandhfq	NOUN
admet-2214	186	8	-	-	PUNCT
admet-2214	186	9	lipid	lipid	NOUN
admet-2214	186	10	liposomes	liposome	NOUN
admet-2214	186	11	could	could	AUX
admet-2214	186	12	potentially	potentially	ADV
admet-2214	186	13	serve	serve	VERB
admet-2214	186	14	as	as	ADP
admet-2214	186	15	a	a	DET
admet-2214	186	16	suitable	suitable	ADJ
admet-2214	186	17	alternative	alternative	NOUN
admet-2214	186	18	to	to	ADP
admet-2214	186	19	ligandpeg2k	ligandpeg2k	NOUN
admet-2214	186	20	-	-	PUNCT
admet-2214	186	21	lipid	lipid	NOUN
admet-2214	186	22	-	-	PUNCT
admet-2214	186	23	modified	modify	VERB
admet-2214	186	24	liposomes	liposome	NOUN
admet-2214	186	25	for	for	ADP
admet-2214	186	26	drug	drug	NOUN
admet-2214	186	27	delivery	delivery	NOUN
admet-2214	186	28	in	in	ADP
admet-2214	186	29	tumor	tumor	NOUN
admet-2214	186	30	targeting	target	VERB
admet-2214	186	31	.	.	PUNCT
admet-2214	187	1	artesunate	artesunate	PROPN
admet-2214	187	2	,	,	PUNCT
admet-2214	187	3	temozolamide	temozolamide	ADP
admet-2214	187	4	[	[	X
admet-2214	187	5	74	74	NUM
admet-2214	187	6	]	]	X
admet-2214	187	7	liposomes	liposome	NOUN
admet-2214	187	8	mpeg2k	mpeg2k	NOUN
admet-2214	187	9	-	-	PUNCT
admet-2214	187	10	dspe	dspe	PROPN
admet-2214	187	11	,	,	PUNCT
admet-2214	187	12	fluorescein	fluorescein	NOUN
admet-2214	187	13	isothiocyanate	isothiocyanate	NOUN
admet-2214	187	14	isomer	isomer	PROPN
admet-2214	187	15	i	i	PROPN
admet-2214	187	16	-	-	PUNCT
admet-2214	187	17	dextran	dextran	NOUN
admet-2214	187	18	,	,	PUNCT
admet-2214	187	19	target	target	NOUN
admet-2214	187	20	apoepeptide	apoepeptide	ADV
admet-2214	187	21	with	with	ADP
admet-2214	187	22	thiol	thiol	PROPN
admet-2214	187	23	adistinct	adistinct	VERB
admet-2214	187	24	mixture	mixture	NOUN
admet-2214	187	25	artesunate	artesunate	NOUN
admet-2214	187	26	-	-	PUNCT
admet-2214	187	27	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2214	187	28	(	(	PUNCT
admet-2214	187	29	artpc	artpc	NOUN
admet-2214	187	30	)	)	PUNCT
admet-2214	187	31	encapsulated	encapsulate	VERB
admet-2214	187	32	with	with	ADP
admet-2214	187	33	temozolomide	temozolomide	NOUN
admet-2214	187	34	(	(	PUNCT
admet-2214	187	35	apoe	apoe	NOUN
admet-2214	187	36	-	-	PUNCT
admet-2214	187	37	artpc@tmz	artpc@tmz	NOUN
admet-2214	187	38	)	)	PUNCT
admet-2214	187	39	is	be	AUX
admet-2214	187	40	the	the	DET
admet-2214	187	41	basis	basis	NOUN
admet-2214	187	42	of	of	ADP
admet-2214	187	43	an	an	DET
admet-2214	187	44	apoefunctionalized	apoefunctionalize	VERB
admet-2214	187	45	liposomal	liposomal	ADJ
admet-2214	187	46	nanoplatform	nanoplatform	NOUN
admet-2214	187	47	that	that	PRON
admet-2214	187	48	has	have	AUX
admet-2214	187	49	been	be	AUX
admet-2214	187	50	shown	show	VERB
admet-2214	187	51	to	to	PART
admet-2214	187	52	effectively	effectively	ADV
admet-2214	187	53	co	co	VERB
admet-2214	187	54	-	-	VERB
admet-2214	187	55	deliver	deliver	VERB
admet-2214	187	56	dual	dual	ADJ
admet-2214	187	57	therapeutic	therapeutic	ADJ
admet-2214	187	58	drugs	drug	NOUN
admet-2214	187	59	to	to	ADP
admet-2214	187	60	tmz	tmz	NOUN
admet-2214	187	61	-	-	PUNCT
admet-2214	187	62	resistant	resistant	ADJ
admet-2214	187	63	u251	u251	PROPN
admet-2214	187	64	-	-	PUNCT
admet-2214	187	65	tr	tr	VERB
admet-2214	187	66	gbm	gbm	NOUN
admet-2214	187	67	in	in	ADP
admet-2214	187	68	vivo	vivo	NOUN
admet-2214	187	69	.	.	PUNCT
admet-2214	188	1	not	not	PART
admet-2214	188	2	disclosed	disclose	VERB
admet-2214	188	3	not	not	PART
admet-2214	188	4	disclosed	disclose	VERB
admet-2214	188	5	the	the	DET
admet-2214	188	6	preclinical	preclinical	ADJ
admet-2214	188	7	promise	promise	NOUN
admet-2214	188	8	of	of	ADP
admet-2214	188	9	this	this	DET
admet-2214	188	10	innovative	innovative	ADJ
admet-2214	188	11	integrative	integrative	ADJ
admet-2214	188	12	technique	technique	NOUN
admet-2214	188	13	to	to	PART
admet-2214	188	14	deliver	deliver	VERB
admet-2214	188	15	combination	combination	NOUN
admet-2214	188	16	medicines	medicine	NOUN
admet-2214	188	17	to	to	ADP
admet-2214	188	18	brain	brain	NOUN
admet-2214	188	19	tumors	tumor	NOUN
admet-2214	188	20	was	be	AUX
admet-2214	188	21	demonstrated	demonstrate	VERB
admet-2214	188	22	through	through	ADP
admet-2214	188	23	the	the	DET
admet-2214	188	24	use	use	NOUN
admet-2214	188	25	of	of	ADP
admet-2214	188	26	combination	combination	NOUN
admet-2214	188	27	liposomes	liposome	NOUN
admet-2214	188	28	.	.	PUNCT
admet-2214	189	1	by	by	ADP
admet-2214	189	2	reducing	reduce	VERB
admet-2214	189	3	the	the	DET
admet-2214	189	4	effective	effective	ADJ
admet-2214	189	5	dosage	dosage	NOUN
admet-2214	189	6	of	of	ADP
admet-2214	189	7	tmz	tmz	NOUN
admet-2214	189	8	and	and	CCONJ
admet-2214	189	9	thereby	thereby	ADV
admet-2214	189	10	mitigating	mitigate	VERB
admet-2214	189	11	systemic	systemic	ADJ
admet-2214	189	12	tmz	tmz	NOUN
admet-2214	189	13	-	-	PUNCT
admet-2214	189	14	induced	induce	VERB
admet-2214	189	15	toxicity	toxicity	NOUN
admet-2214	189	16	,	,	PUNCT
admet-2214	189	17	this	this	DET
admet-2214	189	18	approach	approach	NOUN
admet-2214	189	19	shows	show	VERB
admet-2214	189	20	great	great	ADJ
admet-2214	189	21	potential	potential	NOUN
admet-2214	189	22	.	.	PUNCT
admet-2214	190	1	role	role	NOUN
admet-2214	190	2	of	of	ADP
admet-2214	190	3	solid	solid	ADJ
admet-2214	190	4	lipid	lipid	NOUN
admet-2214	190	5	nanoparticles	nanoparticle	NOUN
admet-2214	190	6	in	in	ADP
admet-2214	190	7	dipg	dipg	NOUN
admet-2214	190	8	drug	drug	NOUN
admet-2214	190	9	-	-	PUNCT
admet-2214	190	10	incorporated	incorporate	VERB
admet-2214	190	11	,	,	PUNCT
admet-2214	190	12	highly	highly	ADV
admet-2214	190	13	ordered	order	VERB
admet-2214	190	14	crystalline	crystalline	NOUN
admet-2214	190	15	structure	structure	NOUN
admet-2214	190	16	with	with	ADP
admet-2214	190	17	emulsifiers	emulsifier	NOUN
admet-2214	190	18	characterises	characterise	VERB
admet-2214	190	19	slns	slns	NOUN
admet-2214	190	20	made	make	VERB
admet-2214	190	21	up	up	ADP
admet-2214	190	22	of	of	ADP
admet-2214	190	23	fully	fully	ADV
admet-2214	190	24	crystallised	crystallise	VERB
admet-2214	190	25	lipid	lipid	NOUN
admet-2214	190	26	components	component	NOUN
admet-2214	190	27	.	.	PUNCT
admet-2214	191	1	the	the	DET
admet-2214	191	2	first	first	ADJ
admet-2214	191	3	slns	slns	NOUN
admet-2214	191	4	were	be	AUX
admet-2214	191	5	created	create	VERB
admet-2214	191	6	in	in	ADP
admet-2214	191	7	the	the	DET
admet-2214	191	8	mid-1990s	mid-1990	NOUN
admet-2214	191	9	using	use	VERB
admet-2214	191	10	lipids	lipid	NOUN
admet-2214	191	11	,	,	PUNCT
admet-2214	191	12	including	include	VERB
admet-2214	191	13	triglycerides	triglyceride	NOUN
admet-2214	191	14	,	,	PUNCT
admet-2214	191	15	fatty	fatty	NOUN
admet-2214	191	16	acids	acid	NOUN
admet-2214	191	17	,	,	PUNCT
admet-2214	191	18	and	and	CCONJ
admet-2214	191	19	waxes	wax	NOUN
admet-2214	191	20	,	,	PUNCT
admet-2214	191	21	with	with	ADP
admet-2214	191	22	melting	melting	NOUN
admet-2214	191	23	points	point	NOUN
admet-2214	191	24	greater	great	ADJ
admet-2214	191	25	than	than	ADP
admet-2214	191	26	both	both	DET
admet-2214	191	27	body	body	NOUN
admet-2214	191	28	and	and	CCONJ
admet-2214	191	29	room	room	NOUN
admet-2214	191	30	temperature	temperature	NOUN
admet-2214	192	1	[	[	X
admet-2214	192	2	75,76	75,76	NOUN
admet-2214	192	3	]	]	X
admet-2214	192	4	.	.	PUNCT
admet-2214	193	1	slns	slns	PROPN
admet-2214	193	2	offer	offer	VERB
admet-2214	193	3	numerous	numerous	ADJ
admet-2214	193	4	benefits	benefit	NOUN
admet-2214	193	5	,	,	PUNCT
admet-2214	193	6	including	include	VERB
admet-2214	193	7	enhanced	enhance	VERB
admet-2214	193	8	drug	drug	NOUN
admet-2214	193	9	protection	protection	NOUN
admet-2214	193	10	,	,	PUNCT
admet-2214	193	11	better	well	ADJ
admet-2214	193	12	nanoparticle	nanoparticle	NOUN
admet-2214	193	13	stability	stability	NOUN
admet-2214	193	14	,	,	PUNCT
admet-2214	193	15	and	and	CCONJ
admet-2214	193	16	controlled	control	VERB
admet-2214	193	17	release	release	NOUN
admet-2214	193	18	characteristics	characteristic	NOUN
admet-2214	193	19	that	that	PRON
admet-2214	193	20	can	can	AUX
admet-2214	193	21	be	be	AUX
admet-2214	193	22	adjusted	adjust	VERB
admet-2214	193	23	by	by	ADP
admet-2214	193	24	changing	change	VERB
admet-2214	193	25	the	the	DET
admet-2214	193	26	lipid	lipid	NOUN
admet-2214	193	27	composition	composition	NOUN
admet-2214	193	28	[	[	X
admet-2214	193	29	77	77	NUM
admet-2214	193	30	]	]	SYM
admet-2214	193	31	.	.	PUNCT
admet-2214	194	1	slns	slns	PROPN
admet-2214	194	2	,	,	PUNCT
admet-2214	194	3	however	however	ADV
admet-2214	194	4	,	,	PUNCT
admet-2214	194	5	have	have	VERB
admet-2214	194	6	two	two	NUM
admet-2214	194	7	main	main	ADJ
admet-2214	194	8	issues	issue	NOUN
admet-2214	194	9	:	:	PUNCT
admet-2214	194	10	low	low	ADJ
admet-2214	194	11	drug	drug	NOUN
admet-2214	194	12	loading	loading	NOUN
admet-2214	194	13	capacity	capacity	NOUN
admet-2214	194	14	and	and	CCONJ
admet-2214	194	15	poor	poor	ADJ
admet-2214	194	16	long	long	ADJ
admet-2214	194	17	-	-	PUNCT
admet-2214	194	18	term	term	NOUN
admet-2214	194	19	drug	drug	NOUN
admet-2214	194	20	retention	retention	NOUN
admet-2214	194	21	.	.	PUNCT
admet-2214	195	1	during	during	ADP
admet-2214	195	2	the	the	DET
admet-2214	195	3	storage	storage	NOUN
admet-2214	195	4	process	process	NOUN
admet-2214	195	5	,	,	PUNCT
admet-2214	195	6	a	a	DET
admet-2214	195	7	remarkable	remarkable	ADJ
admet-2214	195	8	phenomenon	phenomenon	NOUN
admet-2214	195	9	takes	take	VERB
admet-2214	195	10	place	place	NOUN
admet-2214	195	11	:	:	PUNCT
admet-2214	195	12	lipids	lipid	NOUN
admet-2214	195	13	undergo	undergo	VERB
admet-2214	195	14	a	a	DET
admet-2214	195	15	polymorphic	polymorphic	ADJ
admet-2214	195	16	transition	transition	NOUN
admet-2214	195	17	from	from	ADP
admet-2214	195	18	a	a	DET
admet-2214	195	19	very	very	ADJ
admet-2214	195	20	highenergy	highenergy	NOUN
admet-2214	195	21	phase	phase	NOUN
admet-2214	195	22	to	to	ADP
admet-2214	195	23	a	a	DET
admet-2214	195	24	low	low	ADJ
admet-2214	195	25	-	-	PUNCT
admet-2214	195	26	energy	energy	NOUN
admet-2214	195	27	phase	phase	NOUN
admet-2214	195	28	.	.	PUNCT
admet-2214	196	1	this	this	DET
admet-2214	196	2	transition	transition	NOUN
admet-2214	196	3	leads	lead	VERB
admet-2214	196	4	to	to	ADP
admet-2214	196	5	the	the	DET
admet-2214	196	6	development	development	NOUN
admet-2214	196	7	of	of	ADP
admet-2214	196	8	a	a	DET
admet-2214	196	9	meticulously	meticulously	ADV
admet-2214	196	10	well	well	ADV
admet-2214	196	11	-	-	PUNCT
admet-2214	196	12	formed	form	VERB
admet-2214	196	13	crystalline	crystalline	NOUN
admet-2214	196	14	structure	structure	NOUN
admet-2214	196	15	,	,	PUNCT
admet-2214	196	16	adding	add	VERB
admet-2214	196	17	an	an	DET
admet-2214	196	18	intriguing	intriguing	ADJ
admet-2214	196	19	dimension	dimension	NOUN
admet-2214	196	20	to	to	ADP
admet-2214	196	21	the	the	DET
admet-2214	196	22	overall	overall	ADJ
admet-2214	196	23	process	process	NOUN
admet-2214	196	24	.	.	PUNCT
admet-2214	197	1	additionally	additionally	ADV
admet-2214	197	2	,	,	PUNCT
admet-2214	197	3	it	it	PRON
admet-2214	197	4	is	be	AUX
admet-2214	197	5	worth	worth	ADJ
admet-2214	197	6	noting	note	VERB
admet-2214	197	7	that	that	SCONJ
admet-2214	197	8	this	this	DET
admet-2214	197	9	transition	transition	NOUN
admet-2214	197	10	also	also	ADV
admet-2214	197	11	has	have	VERB
admet-2214	197	12	an	an	DET
admet-2214	197	13	impact	impact	NOUN
admet-2214	197	14	on	on	ADP
admet-2214	197	15	the	the	DET
admet-2214	197	16	encapsulated	encapsulate	VERB
admet-2214	197	17	pharmaceuticals	pharmaceutical	NOUN
admet-2214	197	18	,	,	PUNCT
admet-2214	197	19	gradually	gradually	ADV
admet-2214	197	20	causing	cause	VERB
admet-2214	197	21	them	they	PRON
admet-2214	197	22	to	to	PART
admet-2214	197	23	leak	leak	VERB
admet-2214	197	24	out	out	ADP
admet-2214	197	25	over	over	ADP
admet-2214	197	26	time	time	NOUN
admet-2214	197	27	.	.	PUNCT
admet-2214	198	1	hence	hence	ADV
admet-2214	198	2	,	,	PUNCT
admet-2214	198	3	the	the	DET
admet-2214	198	4	polymorphism	polymorphism	NOUN
admet-2214	198	5	severely	severely	ADV
admet-2214	198	6	restricts	restrict	VERB
admet-2214	198	7	the	the	DET
admet-2214	198	8	amount	amount	NOUN
admet-2214	198	9	of	of	ADP
admet-2214	198	10	drug	drug	NOUN
admet-2214	198	11	loading	loading	NOUN
admet-2214	198	12	capability	capability	NOUN
admet-2214	198	13	,	,	PUNCT
admet-2214	198	14	particularly	particularly	ADV
admet-2214	198	15	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	198	16	z.	z.	PROPN
admet-2214	198	17	presswala	presswala	PROPN
admet-2214	198	18	et	et	PROPN
admet-2214	198	19	al	al	PROPN
admet-2214	198	20	.	.	PROPN
admet-2214	198	21	admet	admet	PROPN
admet-2214	198	22	&	&	CCONJ
admet-2214	198	23	dmpk	dmpk	PROPN
admet-2214	198	24	12(3	12(3	PROPN
admet-2214	198	25	)	)	PUNCT
admet-2214	198	26	(	(	PUNCT
admet-2214	198	27	2024	2024	NUM
admet-2214	198	28	)	)	PUNCT
admet-2214	198	29	403	403	NUM
admet-2214	198	30	-	-	SYM
admet-2214	198	31	429	429	NUM
admet-2214	198	32	414	414	NUM
admet-2214	198	33	for	for	ADP
admet-2214	198	34	highly	highly	ADV
admet-2214	198	35	pure	pure	ADJ
admet-2214	198	36	lipids	lipid	NOUN
admet-2214	198	37	[	[	X
admet-2214	198	38	78,79	78,79	NOUN
admet-2214	198	39	]	]	PUNCT
admet-2214	198	40	.	.	PUNCT
admet-2214	199	1	various	various	ADJ
admet-2214	199	2	methods	method	NOUN
admet-2214	199	3	are	be	AUX
admet-2214	199	4	used	use	VERB
admet-2214	199	5	for	for	ADP
admet-2214	199	6	preparing	prepare	VERB
admet-2214	199	7	solid	solid	ADJ
admet-2214	199	8	lipid	lipid	ADJ
admet-2214	199	9	nanoparticles	nanoparticle	NOUN
admet-2214	199	10	,	,	PUNCT
admet-2214	199	11	such	such	ADJ
admet-2214	199	12	as	as	ADP
admet-2214	199	13	high	high	ADJ
admet-2214	199	14	shear	shear	NOUN
admet-2214	199	15	homogenization	homogenization	NOUN
admet-2214	199	16	,	,	PUNCT
admet-2214	199	17	high	high	ADJ
admet-2214	199	18	-	-	PUNCT
admet-2214	199	19	speed	speed	NOUN
admet-2214	199	20	homogenization	homogenization	NOUN
admet-2214	199	21	or	or	CCONJ
admet-2214	199	22	ultra	ultra	ADJ
admet-2214	199	23	-	-	ADJ
admet-2214	199	24	sonication	sonication	NOUN
admet-2214	199	25	,	,	PUNCT
admet-2214	199	26	solvent	solvent	NOUN
admet-2214	199	27	emulsification	emulsification	NOUN
admet-2214	199	28	/	/	SYM
admet-2214	199	29	evaporation	evaporation	NOUN
admet-2214	199	30	,	,	PUNCT
admet-2214	199	31	micro	micro	ADJ
admet-2214	199	32	emulsions	emulsion	NOUN
admet-2214	199	33	,	,	PUNCT
admet-2214	199	34	double	double	ADJ
admet-2214	199	35	emulsion	emulsion	NOUN
admet-2214	199	36	,	,	PUNCT
admet-2214	199	37	spray	spray	VERB
admet-2214	199	38	drying	dry	VERB
admet-2214	199	39	,	,	PUNCT
admet-2214	199	40	sln	sln	PROPN
admet-2214	199	41	preparation	preparation	NOUN
admet-2214	199	42	by	by	ADP
admet-2214	199	43	using	use	VERB
admet-2214	199	44	super	super	ADJ
admet-2214	199	45	critical	critical	ADJ
admet-2214	199	46	fluid	fluid	NOUN
admet-2214	200	1	[	[	X
admet-2214	200	2	80	80	NUM
admet-2214	200	3	]	]	PUNCT
admet-2214	200	4	.	.	PUNCT
admet-2214	201	1	the	the	DET
admet-2214	201	2	following	follow	VERB
admet-2214	201	3	table	table	NOUN
admet-2214	201	4	highlights	highlight	VERB
admet-2214	201	5	the	the	DET
admet-2214	201	6	preclinical	preclinical	ADJ
admet-2214	201	7	studies	study	NOUN
admet-2214	201	8	on	on	ADP
admet-2214	201	9	solid	solid	ADJ
admet-2214	201	10	lipid	lipid	NOUN
admet-2214	201	11	nanoparticles	nanoparticle	NOUN
admet-2214	201	12	conducted	conduct	VERB
admet-2214	201	13	in	in	ADP
admet-2214	201	14	dipg	dipg	NOUN
admet-2214	201	15	.	.	PUNCT
admet-2214	202	1	preclinical	preclinical	ADJ
admet-2214	202	2	studies	study	NOUN
admet-2214	202	3	of	of	ADP
admet-2214	202	4	solid	solid	ADJ
admet-2214	202	5	lipid	lipid	NOUN
admet-2214	202	6	nanoparticles	nanoparticle	NOUN
admet-2214	202	7	in	in	ADP
admet-2214	202	8	dipg	dipg	NOUN
admet-2214	202	9	has	have	AUX
admet-2214	202	10	been	be	AUX
admet-2214	202	11	illustrated	illustrate	VERB
admet-2214	202	12	in	in	ADP
admet-2214	202	13	table	table	NOUN
admet-2214	202	14	3	3	NUM
admet-2214	202	15	.	.	PUNCT
admet-2214	202	16	table	table	NOUN
admet-2214	202	17	3	3	NUM
admet-2214	202	18	.	.	PUNCT
admet-2214	202	19	preclinical	preclinical	ADJ
admet-2214	202	20	studies	study	NOUN
admet-2214	202	21	of	of	ADP
admet-2214	202	22	solid	solid	ADJ
admet-2214	202	23	lipid	lipid	NOUN
admet-2214	202	24	nanoparticles	nanoparticle	NOUN
admet-2214	202	25	in	in	ADP
admet-2214	202	26	dipg	dipg	NOUN
admet-2214	202	27	drug	drug	NOUN
admet-2214	202	28	formulation	formulation	NOUN
admet-2214	202	29	excipients	excipient	NOUN
admet-2214	202	30	overview	overview	VERB
admet-2214	202	31	method	method	NOUN
admet-2214	202	32	of	of	ADP
admet-2214	202	33	preparation	preparation	NOUN
admet-2214	202	34	evaluation	evaluation	NOUN
admet-2214	202	35	parameters	parameter	NOUN
admet-2214	202	36	outcome	outcome	VERB
admet-2214	202	37	carmiustine	carmiustine	NOUN
admet-2214	202	38	(	(	PUNCT
admet-2214	202	39	bcnu	bcnu	NOUN
admet-2214	202	40	)	)	PUNCT
admet-2214	202	41	temozolamide	temozolamide	NOUN
admet-2214	202	42	(	(	PUNCT
admet-2214	202	43	tmz	tmz	PROPN
admet-2214	202	44	)	)	PUNCT
admet-2214	203	1	[	[	X
admet-2214	203	2	81	81	NUM
admet-2214	203	3	]	]	PUNCT
admet-2214	203	4	solid	solid	ADJ
admet-2214	203	5	lipid	lipid	NOUN
admet-2214	203	6	nanoparticles	nanoparticle	NOUN
admet-2214	203	7	cetyl	cetyl	NOUN
admet-2214	203	8	palmitate	palmitate	NOUN
admet-2214	203	9	,	,	PUNCT
admet-2214	203	10	β	β	NOUN
admet-2214	203	11	-	-	ADJ
admet-2214	203	12	hydroxybutyric	hydroxybutyric	ADJ
admet-2214	203	13	acid	acid	NOUN
admet-2214	203	14	the	the	DET
admet-2214	203	15	objective	objective	NOUN
admet-2214	203	16	of	of	ADP
admet-2214	203	17	this	this	DET
admet-2214	203	18	study	study	NOUN
admet-2214	203	19	was	be	AUX
admet-2214	203	20	to	to	PART
admet-2214	203	21	formulate	formulate	VERB
admet-2214	203	22	and	and	CCONJ
admet-2214	203	23	develop	develop	VERB
admet-2214	203	24	solid	solid	ADJ
admet-2214	203	25	lipid	lipid	NOUN
admet-2214	203	26	nanoparticles	nanoparticle	NOUN
admet-2214	203	27	(	(	PUNCT
admet-2214	203	28	sln	sln	PROPN
admet-2214	203	29	)	)	PUNCT
admet-2214	203	30	with	with	ADP
admet-2214	203	31	the	the	DET
admet-2214	203	32	intention	intention	NOUN
admet-2214	203	33	of	of	ADP
admet-2214	203	34	enhancing	enhance	VERB
admet-2214	203	35	their	their	PRON
admet-2214	203	36	antiproliferative	antiproliferative	ADJ
admet-2214	203	37	effects	effect	NOUN
admet-2214	203	38	against	against	ADP
admet-2214	203	39	glioblastoma	glioblastoma	NOUN
admet-2214	203	40	multiforme	multiforme	NOUN
admet-2214	203	41	(	(	PUNCT
admet-2214	203	42	gbm	gbm	NOUN
admet-2214	203	43	)	)	PUNCT
admet-2214	203	44	.	.	PUNCT
admet-2214	204	1	not	not	PART
admet-2214	204	2	disclosed	disclose	VERB
admet-2214	204	3	size	size	NOUN
admet-2214	204	4	,	,	PUNCT
admet-2214	204	5	morphology	morphology	NOUN
admet-2214	204	6	,	,	PUNCT
admet-2214	204	7	chemical	chemical	NOUN
admet-2214	204	8	structure	structure	NOUN
admet-2214	204	9	,	,	PUNCT
admet-2214	204	10	zeta	zeta	NOUN
admet-2214	204	11	potential	potential	NOUN
admet-2214	204	12	,	,	PUNCT
admet-2214	204	13	drug	drug	NOUN
admet-2214	204	14	encapsulation	encapsulation	NOUN
admet-2214	204	15	efficacy	efficacy	NOUN
admet-2214	204	16	,	,	PUNCT
admet-2214	204	17	drug	drug	NOUN
admet-2214	204	18	release	release	NOUN
admet-2214	204	19	,	,	PUNCT
admet-2214	204	20	biocompatibility	biocompatibility	NOUN
admet-2214	204	21	,	,	PUNCT
admet-2214	204	22	stability	stability	NOUN
admet-2214	204	23	were	be	AUX
admet-2214	204	24	determined	determine	VERB
admet-2214	204	25	,	,	PUNCT
admet-2214	204	26	and	and	CCONJ
admet-2214	204	27	in	in	ADP
admet-2214	204	28	vitro	vitro	X
admet-2214	204	29	studies	study	NOUN
admet-2214	204	30	the	the	DET
admet-2214	204	31	bcnu	bcnu	NOUN
admet-2214	204	32	and	and	CCONJ
admet-2214	204	33	tmz	tmz	PROPN
admet-2214	204	34	loaded	load	VERB
admet-2214	204	35	solid	solid	ADJ
admet-2214	204	36	lipid	lipid	NOUN
admet-2214	204	37	nanoparticles	nanoparticle	NOUN
admet-2214	204	38	(	(	PUNCT
admet-2214	204	39	slns	slns	NOUN
admet-2214	204	40	)	)	PUNCT
admet-2214	204	41	demonstrated	demonstrate	VERB
admet-2214	204	42	a	a	DET
admet-2214	204	43	noteworthy	noteworthy	ADJ
admet-2214	204	44	increase	increase	NOUN
admet-2214	204	45	in	in	ADP
admet-2214	204	46	their	their	PRON
admet-2214	204	47	antitumor	antitumor	NOUN
admet-2214	204	48	activity	activity	NOUN
admet-2214	204	49	when	when	SCONJ
admet-2214	204	50	compared	compare	VERB
admet-2214	204	51	to	to	ADP
admet-2214	204	52	the	the	DET
admet-2214	204	53	free	free	ADJ
admet-2214	204	54	-	-	PUNCT
admet-2214	204	55	drugs	drug	NOUN
admet-2214	204	56	.	.	PUNCT
admet-2214	205	1	additionally	additionally	ADV
admet-2214	205	2	,	,	PUNCT
admet-2214	205	3	these	these	DET
admet-2214	205	4	slns	slns	NOUN
admet-2214	205	5	were	be	AUX
admet-2214	205	6	found	find	VERB
admet-2214	205	7	to	to	PART
admet-2214	205	8	induce	induce	VERB
admet-2214	205	9	apoptosis	apoptosis	NOUN
admet-2214	205	10	on	on	ADP
admet-2214	205	11	u87	u87	ADJ
admet-2214	205	12	mg	mg	PROPN
admet-2214	205	13	cells	cell	NOUN
admet-2214	205	14	,	,	PUNCT
admet-2214	205	15	further	far	ADV
admet-2214	205	16	highlighting	highlight	VERB
admet-2214	205	17	their	their	PRON
admet-2214	205	18	potential	potential	ADJ
admet-2214	205	19	therapeutic	therapeutic	ADJ
admet-2214	205	20	efficacy	efficacy	NOUN
admet-2214	205	21	.	.	PUNCT
admet-2214	206	1	furthermore	furthermore	ADV
admet-2214	206	2	,	,	PUNCT
admet-2214	206	3	it	it	PRON
admet-2214	206	4	was	be	AUX
admet-2214	206	5	observed	observe	VERB
admet-2214	206	6	that	that	SCONJ
admet-2214	206	7	brain	brain	NOUN
admet-2214	206	8	cells	cell	NOUN
admet-2214	206	9	expressing	express	VERB
admet-2214	206	10	mct-1	mct-1	PUNCT
admet-2214	206	11	exhibited	exhibit	VERB
admet-2214	206	12	a	a	DET
admet-2214	206	13	higher	high	ADJ
admet-2214	206	14	uptake	uptake	NOUN
admet-2214	206	15	of	of	ADP
admet-2214	206	16	the	the	DET
admet-2214	206	17	specifically	specifically	ADV
admet-2214	206	18	targeted	target	VERB
admet-2214	206	19	nanoparticles	nanoparticle	NOUN
admet-2214	206	20	.	.	PUNCT
admet-2214	207	1	asiatic	asiatic	ADJ
admet-2214	207	2	acid	acid	NOUN
admet-2214	208	1	[	[	X
admet-2214	208	2	82	82	NUM
admet-2214	208	3	]	]	X
admet-2214	208	4	solid	solid	ADJ
admet-2214	208	5	lipid	lipid	NOUN
admet-2214	208	6	nanoparticles	nanoparticle	NOUN
admet-2214	208	7	glyceryl	glyceryl	NOUN
admet-2214	208	8	tristearate	tristearate	NOUN
admet-2214	208	9	,	,	PUNCT
admet-2214	208	10	chloroform	chloroform	NOUN
admet-2214	208	11	,	,	PUNCT
admet-2214	208	12	acetic	acetic	ADJ
admet-2214	208	13	acid	acid	NOUN
admet-2214	208	14	,	,	PUNCT
admet-2214	208	15	l	l	NOUN
admet-2214	208	16	-	-	NOUN
admet-2214	208	17	glutamine	glutamine	NOUN
admet-2214	208	18	,	,	PUNCT
admet-2214	208	19	poloxamer	poloxamer	NOUN
admet-2214	208	20	188	188	NUM
admet-2214	208	21	the	the	DET
admet-2214	208	22	present	present	ADJ
admet-2214	208	23	study	study	NOUN
admet-2214	208	24	aimed	aim	VERB
admet-2214	208	25	to	to	PART
admet-2214	208	26	evaluate	evaluate	VERB
admet-2214	208	27	the	the	DET
admet-2214	208	28	effecttiveness	effecttiveness	NOUN
admet-2214	208	29	of	of	ADP
admet-2214	208	30	solid	solid	ADJ
admet-2214	208	31	lipid	lipid	NOUN
admet-2214	208	32	nanoparticles	nanoparticle	NOUN
admet-2214	208	33	(	(	PUNCT
admet-2214	208	34	slns	slns	NOUN
admet-2214	208	35	)	)	PUNCT
admet-2214	208	36	loaded	load	VERB
admet-2214	208	37	with	with	ADP
admet-2214	208	38	aa	aa	NOUN
admet-2214	208	39	in	in	ADP
admet-2214	208	40	combating	combat	VERB
admet-2214	208	41	glioblastoma	glioblastoma	NOUN
admet-2214	208	42	,	,	PUNCT
admet-2214	208	43	a	a	DET
admet-2214	208	44	type	type	NOUN
admet-2214	208	45	of	of	ADP
admet-2214	208	46	cancer	cancer	NOUN
admet-2214	208	47	.	.	PUNCT
admet-2214	209	1	additionally	additionally	ADV
admet-2214	209	2	,	,	PUNCT
admet-2214	209	3	the	the	DET
admet-2214	209	4	study	study	NOUN
admet-2214	209	5	sought	seek	VERB
admet-2214	209	6	to	to	PART
admet-2214	209	7	investigate	investigate	VERB
admet-2214	209	8	the	the	DET
admet-2214	209	9	cellular	cellular	ADJ
admet-2214	209	10	uptake	uptake	ADJ
admet-2214	209	11	mechanism	mechanism	NOUN
admet-2214	209	12	of	of	ADP
admet-2214	209	13	these	these	DET
admet-2214	209	14	slns	slns	NOUN
admet-2214	209	15	in	in	ADP
admet-2214	209	16	comparison	comparison	NOUN
admet-2214	209	17	to	to	ADP
admet-2214	209	18	svg	svg	PROPN
admet-2214	209	19	p12	p12	NOUN
admet-2214	209	20	cells	cell	NOUN
admet-2214	209	21	,	,	PUNCT
admet-2214	209	22	which	which	PRON
admet-2214	209	23	are	be	AUX
admet-2214	209	24	human	human	ADJ
admet-2214	209	25	fetal	fetal	ADJ
admet-2214	209	26	glial	glial	ADJ
admet-2214	209	27	cells	cell	NOUN
admet-2214	209	28	.	.	PUNCT
admet-2214	210	1	solvent	solvent	ADJ
admet-2214	210	2	evaporation	evaporation	NOUN
admet-2214	210	3	and	and	CCONJ
admet-2214	210	4	hot	hot	ADJ
admet-2214	210	5	homogenisation	homogenisation	NOUN
admet-2214	210	6	technique	technique	NOUN
admet-2214	210	7	size	size	NOUN
admet-2214	210	8	analysis	analysis	NOUN
admet-2214	210	9	and	and	CCONJ
admet-2214	210	10	zeta	zeta	NOUN
admet-2214	210	11	potential	potential	NOUN
admet-2214	210	12	,	,	PUNCT
admet-2214	210	13	entrapment	entrapment	ADJ
admet-2214	210	14	efficiency	efficiency	NOUN
admet-2214	210	15	,	,	PUNCT
admet-2214	210	16	hplc	hplc	NOUN
admet-2214	210	17	,	,	PUNCT
admet-2214	210	18	xrd	xrd	NOUN
admet-2214	210	19	,	,	PUNCT
admet-2214	210	20	%	%	NOUN
admet-2214	210	21	in	in	ADP
admet-2214	210	22	-	-	PUNCT
admet-2214	210	23	vitro	vitro	X
admet-2214	210	24	drug	drug	NOUN
admet-2214	210	25	release	release	NOUN
admet-2214	210	26	,	,	PUNCT
admet-2214	210	27	cell	cell	NOUN
admet-2214	210	28	uptake	uptake	ADJ
admet-2214	210	29	study	study	NOUN
admet-2214	210	30	,	,	PUNCT
admet-2214	210	31	apoptosis	apoptosis	NOUN
admet-2214	210	32	study	study	NOUN
admet-2214	210	33	,	,	PUNCT
admet-2214	210	34	y	y	PROPN
admet-2214	210	35	fluorescence	fluorescence	NOUN
admet-2214	210	36	imaging	imaging	NOUN
admet-2214	210	37	and	and	CCONJ
admet-2214	210	38	flow	flow	NOUN
admet-2214	210	39	cell	cell	NOUN
admet-2214	210	40	cytometry	cytometry	NOUN
admet-2214	210	41	solid	solid	ADJ
admet-2214	210	42	lipid	lipid	NOUN
admet-2214	210	43	nanoparticles	nanoparticle	NOUN
admet-2214	210	44	(	(	PUNCT
admet-2214	210	45	slns	slns	NOUN
admet-2214	210	46	)	)	PUNCT
admet-2214	210	47	may	may	AUX
admet-2214	210	48	cure	cure	VERB
admet-2214	210	49	glioma	glioma	NOUN
admet-2214	210	50	,	,	PUNCT
admet-2214	210	51	a	a	DET
admet-2214	210	52	brain	brain	NOUN
admet-2214	210	53	tumor	tumor	NOUN
admet-2214	210	54	.	.	PUNCT
admet-2214	211	1	delivery	delivery	NOUN
admet-2214	211	2	of	of	ADP
admet-2214	211	3	the	the	DET
admet-2214	211	4	drug	drug	NOUN
admet-2214	211	5	to	to	ADP
admet-2214	211	6	its	its	PRON
admet-2214	211	7	target	target	NOUN
admet-2214	211	8	site	site	NOUN
admet-2214	211	9	is	be	AUX
admet-2214	211	10	efficient	efficient	ADJ
admet-2214	211	11	due	due	ADP
admet-2214	211	12	to	to	ADP
admet-2214	211	13	these	these	DET
admet-2214	211	14	nanoparticles	nanoparticle	NOUN
admet-2214	211	15	'	'	PART
admet-2214	211	16	drug	drug	NOUN
admet-2214	211	17	encapsulation	encapsulation	NOUN
admet-2214	211	18	effectiveness	effectiveness	NOUN
admet-2214	211	19	.	.	PUNCT
admet-2214	212	1	slns	slns	PROPN
admet-2214	212	2	also	also	ADV
admet-2214	212	3	have	have	VERB
admet-2214	212	4	low	low	ADJ
admet-2214	212	5	toxicity	toxicity	NOUN
admet-2214	212	6	to	to	ADP
admet-2214	212	7	healthy	healthy	ADJ
admet-2214	212	8	cells	cell	NOUN
admet-2214	212	9	,	,	PUNCT
admet-2214	212	10	which	which	PRON
admet-2214	212	11	is	be	AUX
admet-2214	212	12	important	important	ADJ
admet-2214	212	13	for	for	ADP
admet-2214	212	14	safe	safe	ADJ
admet-2214	212	15	and	and	CCONJ
admet-2214	212	16	successful	successful	ADJ
admet-2214	212	17	therapeutic	therapeutic	ADJ
admet-2214	212	18	development	development	NOUN
admet-2214	212	19	.	.	PUNCT
admet-2214	213	1	for	for	ADP
admet-2214	213	2	glioma	glioma	ADJ
admet-2214	213	3	treatment	treatment	NOUN
admet-2214	213	4	,	,	PUNCT
admet-2214	213	5	slns	slns	NOUN
admet-2214	213	6	supplemented	supplement	VERB
admet-2214	213	7	with	with	ADP
admet-2214	213	8	ascorbic	ascorbic	NOUN
admet-2214	213	9	acid	acid	NOUN
admet-2214	213	10	are	be	AUX
admet-2214	213	11	promising	promise	VERB
admet-2214	213	12	.	.	PUNCT
admet-2214	214	1	these	these	DET
admet-2214	214	2	slns	slns	NOUN
admet-2214	214	3	are	be	AUX
admet-2214	214	4	promising	promise	VERB
admet-2214	214	5	candidates	candidate	NOUN
admet-2214	214	6	for	for	ADP
admet-2214	214	7	treating	treat	VERB
admet-2214	214	8	this	this	DET
admet-2214	214	9	difficult	difficult	ADJ
admet-2214	214	10	condition	condition	NOUN
admet-2214	214	11	due	due	ADP
admet-2214	214	12	to	to	ADP
admet-2214	214	13	their	their	PRON
admet-2214	214	14	excellent	excellent	ADJ
admet-2214	214	15	drug	drug	NOUN
admet-2214	214	16	encapsulation	encapsulation	NOUN
admet-2214	214	17	efficiency	efficiency	NOUN
admet-2214	214	18	and	and	CCONJ
admet-2214	214	19	minimal	minimal	ADJ
admet-2214	214	20	toxicity	toxicity	NOUN
admet-2214	214	21	.	.	PUNCT
admet-2214	215	1	emodin	emodin	VERB
admet-2214	216	1	[	[	X
admet-2214	216	2	83	83	NUM
admet-2214	216	3	]	]	PUNCT
admet-2214	216	4	solid	solid	ADJ
admet-2214	216	5	lipid	lipid	NOUN
admet-2214	216	6	nanoparticles	nanoparticle	NOUN
admet-2214	216	7	via	via	ADP
admet-2214	216	8	poloxamer	poloxamer	PROPN
admet-2214	216	9	188	188	NUM
admet-2214	216	10	,	,	PUNCT
admet-2214	216	11	tween	tween	NOUN
admet-2214	216	12	80	80	NUM
admet-2214	216	13	this	this	DET
admet-2214	216	14	study	study	NOUN
admet-2214	216	15	prepared	prepare	VERB
admet-2214	216	16	and	and	CCONJ
admet-2214	216	17	characterized	characterize	VERB
admet-2214	216	18	solid	solid	ADJ
admet-2214	216	19	lipid	lipid	NOUN
admet-2214	216	20	nanoparticles	nanoparticle	NOUN
admet-2214	216	21	loaded	load	VERB
admet-2214	216	22	with	with	ADP
admet-2214	216	23	emodin	emodin	PROPN
admet-2214	216	24	(	(	PUNCT
admet-2214	216	25	e	e	NOUN
admet-2214	216	26	-	-	NOUN
admet-2214	216	27	slns	slns	NOUN
admet-2214	216	28	)	)	PUNCT
admet-2214	216	29	and	and	CCONJ
admet-2214	216	30	tested	test	VERB
admet-2214	216	31	their	their	PRON
admet-2214	216	32	in	in	ADP
admet-2214	216	33	vitro	vitro	X
admet-2214	216	34	anticancer	anticancer	NOUN
admet-2214	216	35	efficacy	efficacy	NOUN
admet-2214	216	36	.	.	PUNCT
admet-2214	217	1	high	high	ADJ
admet-2214	217	2	pressure	pressure	NOUN
admet-2214	217	3	homogenizati	homogenizati	NOUN
admet-2214	217	4	on	on	ADP
admet-2214	217	5	(	(	PUNCT
admet-2214	217	6	hph	hph	NOUN
admet-2214	217	7	)	)	PUNCT
admet-2214	217	8	particle	particle	NOUN
admet-2214	217	9	size	size	NOUN
admet-2214	217	10	analysis	analysis	NOUN
admet-2214	217	11	,	,	PUNCT
admet-2214	217	12	zeta	zeta	PROPN
admet-2214	217	13	potential	potential	ADJ
admet-2214	217	14	measurement	measurement	NOUN
admet-2214	217	15	,	,	PUNCT
admet-2214	217	16	drug	drug	NOUN
admet-2214	217	17	entrapment	entrapment	ADJ
admet-2214	217	18	efficiency	efficiency	NOUN
admet-2214	217	19	(	(	PUNCT
admet-2214	217	20	ee	ee	PROPN
admet-2214	217	21	)	)	PUNCT
admet-2214	217	22	,	,	PUNCT
admet-2214	217	23	stability	stability	NOUN
admet-2214	217	24	and	and	CCONJ
admet-2214	217	25	in	in	ADP
admet-2214	217	26	vitro	vitro	X
admet-2214	217	27	drug	drug	NOUN
admet-2214	217	28	release	release	NOUN
admet-2214	217	29	behavior	behavior	NOUN
admet-2214	217	30	results	result	NOUN
admet-2214	217	31	suggest	suggest	VERB
admet-2214	217	32	lipid	lipid	PROPN
admet-2214	217	33	nanoparticle	nanoparticle	PROPN
admet-2214	217	34	administration	administration	NOUN
admet-2214	217	35	of	of	ADP
admet-2214	217	36	emo	emo	NOUN
admet-2214	217	37	may	may	AUX
admet-2214	217	38	be	be	AUX
admet-2214	217	39	a	a	DET
admet-2214	217	40	potential	potential	ADJ
admet-2214	217	41	cancer	cancer	NOUN
admet-2214	217	42	treatment	treatment	NOUN
admet-2214	217	43	.	.	PUNCT
admet-2214	218	1	folic	folic	NOUN
admet-2214	218	2	aciddoxorubicin	aciddoxorubicin	PROPN
admet-2214	218	3	(	(	PUNCT
admet-2214	218	4	fad	fad	NOUN
admet-2214	218	5	)	)	PUNCT
admet-2214	219	1	[	[	X
admet-2214	219	2	84	84	NUM
admet-2214	219	3	]	]	PUNCT
admet-2214	219	4	solid	solid	ADJ
admet-2214	219	5	lipid	lipid	NOUN
admet-2214	219	6	nanoparticles	nanoparticle	NOUN
admet-2214	219	7	tween	tween	VERB
admet-2214	219	8	80	80	NUM
admet-2214	219	9	the	the	DET
admet-2214	219	10	objective	objective	NOUN
admet-2214	219	11	of	of	ADP
admet-2214	219	12	this	this	DET
admet-2214	219	13	study	study	NOUN
admet-2214	219	14	was	be	AUX
admet-2214	219	15	to	to	PART
admet-2214	219	16	establish	establish	VERB
admet-2214	219	17	the	the	DET
admet-2214	219	18	formulation	formulation	NOUN
admet-2214	219	19	of	of	ADP
admet-2214	219	20	tween	tween	NOUN
admet-2214	219	21	80coated	80coated	NUM
admet-2214	219	22	solid	solid	ADJ
admet-2214	219	23	lipid	lipid	NOUN
admet-2214	219	24	nanoparticles	nanoparticle	NOUN
admet-2214	219	25	(	(	PUNCT
admet-2214	219	26	slns	slns	NOUN
admet-2214	219	27	)	)	PUNCT
admet-2214	219	28	that	that	PRON
admet-2214	219	29	would	would	AUX
admet-2214	219	30	effectively	effectively	ADV
admet-2214	219	31	encapsulate	encapsulate	VERB
admet-2214	219	32	the	the	DET
admet-2214	219	33	folic	folic	NOUN
admet-2214	219	34	aciddoxorubicin	aciddoxorubicin	NOUN
admet-2214	219	35	(	(	PUNCT
admet-2214	219	36	fad	fad	NOUN
admet-2214	219	37	)	)	PUNCT
admet-2214	219	38	conjugate	conjugate	VERB
admet-2214	219	39	.	.	PUNCT
admet-2214	220	1	the	the	DET
admet-2214	220	2	ultimate	ultimate	ADJ
admet-2214	220	3	goal	goal	NOUN
admet-2214	220	4	was	be	AUX
admet-2214	220	5	to	to	PART
admet-2214	220	6	achieve	achieve	VERB
admet-2214	220	7	a	a	DET
admet-2214	220	8	targeted	target	VERB
admet-2214	220	9	drug	drug	NOUN
admet-2214	220	10	delivery	delivery	NOUN
admet-2214	220	11	system	system	NOUN
admet-2214	220	12	specifically	specifically	ADV
admet-2214	220	13	designed	design	VERB
admet-2214	220	14	to	to	PART
admet-2214	220	15	target	target	VERB
admet-2214	220	16	brain	brain	NOUN
admet-2214	220	17	cancer	cancer	NOUN
admet-2214	220	18	cells	cell	NOUN
admet-2214	220	19	.	.	PUNCT
admet-2214	221	1	solvent	solvent	ADJ
admet-2214	221	2	injection	injection	NOUN
admet-2214	221	3	method	method	NOUN
admet-2214	221	4	particle	particle	NOUN
admet-2214	221	5	size	size	NOUN
admet-2214	221	6	,	,	PUNCT
admet-2214	221	7	zeta	zeta	NOUN
admet-2214	221	8	potential	potential	NOUN
admet-2214	221	9	,	,	PUNCT
admet-2214	221	10	surface	surface	NOUN
admet-2214	221	11	morphology	morphology	NOUN
admet-2214	221	12	,	,	PUNCT
admet-2214	221	13	entrapment	entrapment	ADJ
admet-2214	221	14	efficiency	efficiency	NOUN
admet-2214	221	15	,	,	PUNCT
admet-2214	221	16	cytotoxicity	cytotoxicity	NOUN
admet-2214	221	17	and	and	CCONJ
admet-2214	221	18	cellular	cellular	ADJ
admet-2214	221	19	uptake	uptake	ADJ
admet-2214	221	20	study	study	NOUN
admet-2214	221	21	the	the	DET
admet-2214	221	22	results	result	NOUN
admet-2214	221	23	of	of	ADP
admet-2214	221	24	the	the	DET
admet-2214	221	25	study	study	NOUN
admet-2214	221	26	have	have	AUX
admet-2214	221	27	confirmed	confirm	VERB
admet-2214	221	28	that	that	SCONJ
admet-2214	221	29	the	the	DET
admet-2214	221	30	use	use	NOUN
admet-2214	221	31	of	of	ADP
admet-2214	221	32	tween	tween	NOUN
admet-2214	221	33	80	80	NUM
admet-2214	221	34	-	-	PUNCT
admet-2214	221	35	coated	coat	VERB
admet-2214	221	36	solid	solid	ADJ
admet-2214	221	37	lipid	lipid	NOUN
admet-2214	221	38	nanoparticles	nanoparticle	NOUN
admet-2214	221	39	(	(	PUNCT
admet-2214	221	40	slns	slns	NOUN
admet-2214	221	41	)	)	PUNCT
admet-2214	221	42	holds	hold	VERB
admet-2214	221	43	promise	promise	NOUN
admet-2214	221	44	for	for	ADP
admet-2214	221	45	targeted	target	VERB
admet-2214	221	46	delivery	delivery	NOUN
admet-2214	221	47	of	of	ADP
admet-2214	221	48	doxorubicin	doxorubicin	PROPN
admet-2214	221	49	specifically	specifically	ADV
admet-2214	221	50	to	to	ADP
admet-2214	221	51	brain	brain	NOUN
admet-2214	221	52	cancer	cancer	NOUN
admet-2214	221	53	cells	cell	NOUN
admet-2214	221	54	.	.	PUNCT
admet-2214	222	1	admet	admet	PROPN
admet-2214	222	2	&	&	CCONJ
admet-2214	222	3	dmpk	dmpk	PROPN
admet-2214	222	4	12(3	12(3	PROPN
admet-2214	222	5	)	)	PUNCT
admet-2214	222	6	(	(	PUNCT
admet-2214	222	7	2024	2024	NUM
admet-2214	222	8	)	)	PUNCT
admet-2214	222	9	403	403	NUM
admet-2214	222	10	-	-	SYM
admet-2214	222	11	429	429	NUM
admet-2214	222	12	addressing	address	VERB
admet-2214	222	13	barriers	barrier	NOUN
admet-2214	222	14	in	in	ADP
admet-2214	222	15	diffuse	diffuse	ADJ
admet-2214	222	16	intrinsic	intrinsic	ADJ
admet-2214	222	17	pontine	pontine	ADJ
admet-2214	222	18	glioma	glioma	NOUN
admet-2214	222	19	doi	doi	NOUN
admet-2214	222	20	:	:	PUNCT
admet-2214	222	21	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	222	22	415	415	NUM
admet-2214	222	23	drug	drug	NOUN
admet-2214	222	24	formulation	formulation	NOUN
admet-2214	222	25	excipients	excipient	NOUN
admet-2214	222	26	overview	overview	VERB
admet-2214	222	27	method	method	NOUN
admet-2214	222	28	of	of	ADP
admet-2214	222	29	preparation	preparation	NOUN
admet-2214	222	30	evaluation	evaluation	NOUN
admet-2214	222	31	parameters	parameter	NOUN
admet-2214	222	32	outcome	outcome	VERB
admet-2214	222	33	paclitaxel	paclitaxel	PROPN
admet-2214	222	34	(	(	PUNCT
admet-2214	222	35	ptx	ptx	PROPN
admet-2214	222	36	)	)	PUNCT
admet-2214	223	1	[	[	X
admet-2214	223	2	85	85	NUM
admet-2214	223	3	]	]	SYM
admet-2214	223	4	solid	solid	ADJ
admet-2214	223	5	lipid	lipid	NOUN
admet-2214	223	6	nanoparticles	nanoparticle	NOUN
admet-2214	223	7	peg	peg	VERB
admet-2214	223	8	600	600	NUM
admet-2214	223	9	,	,	PUNCT
admet-2214	223	10	poloxamer	poloxamer	NOUN
admet-2214	223	11	188	188	NUM
admet-2214	223	12	,	,	PUNCT
admet-2214	223	13	lecithin	lecithin	NOUN
admet-2214	223	14	,	,	PUNCT
admet-2214	223	15	stearic	stearic	ADJ
admet-2214	223	16	acid	acid	NOUN
admet-2214	223	17	,	,	PUNCT
admet-2214	223	18	(	(	PUNCT
admet-2214	223	19	1,2dipalmitoyl	1,2dipalmitoyl	PROPN
admet-2214	223	20	-	-	PUNCT
admet-2214	223	21	sn	sn	NOUN
admet-2214	223	22	-	-	PUNCT
admet-2214	223	23	glycero-3phosphoethanolamine	glycero-3phosphoethanolamine	NOUN
admet-2214	223	24	.	.	PUNCT
admet-2214	224	1	the	the	DET
admet-2214	224	2	objective	objective	NOUN
admet-2214	224	3	of	of	ADP
admet-2214	224	4	this	this	DET
admet-2214	224	5	study	study	NOUN
admet-2214	224	6	was	be	AUX
admet-2214	224	7	to	to	PART
admet-2214	224	8	develop	develop	VERB
admet-2214	224	9	solid	solid	ADJ
admet-2214	224	10	lipid	lipid	NOUN
admet-2214	224	11	nanoparticles	nanoparticle	NOUN
admet-2214	224	12	(	(	PUNCT
admet-2214	224	13	sln	sln	PROPN
admet-2214	224	14	)	)	PUNCT
admet-2214	224	15	that	that	PRON
admet-2214	224	16	have	have	AUX
admet-2214	224	17	been	be	AUX
admet-2214	224	18	modified	modify	VERB
admet-2214	224	19	with	with	ADP
admet-2214	224	20	tyrosine	tyrosine	NOUN
admet-2214	224	21	3	3	NUM
admet-2214	224	22	octreotide	octreotide	NOUN
admet-2214	224	23	(	(	PUNCT
admet-2214	224	24	toc	toc	PROPN
admet-2214	224	25	)	)	PUNCT
admet-2214	224	26	and	and	CCONJ
admet-2214	224	27	loaded	load	VERB
admet-2214	224	28	with	with	ADP
admet-2214	224	29	paclitaxel	paclitaxel	PROPN
admet-2214	224	30	(	(	PUNCT
admet-2214	224	31	ptx	ptx	NOUN
admet-2214	224	32	)	)	PUNCT
admet-2214	224	33	.	.	PUNCT
admet-2214	225	1	the	the	DET
admet-2214	225	2	aim	aim	NOUN
admet-2214	225	3	was	be	AUX
admet-2214	225	4	to	to	PART
admet-2214	225	5	enable	enable	VERB
admet-2214	225	6	a	a	DET
admet-2214	225	7	dualtargeting	dualtargeting	NOUN
admet-2214	225	8	approach	approach	NOUN
admet-2214	225	9	for	for	ADP
admet-2214	225	10	the	the	DET
admet-2214	225	11	treatment	treatment	NOUN
admet-2214	225	12	of	of	ADP
admet-2214	225	13	tumor	tumor	NOUN
admet-2214	225	14	cells	cell	NOUN
admet-2214	225	15	and	and	CCONJ
admet-2214	225	16	necrosis	necrosis	NOUN
admet-2214	225	17	vessels	vessel	NOUN
admet-2214	225	18	.	.	PUNCT
admet-2214	226	1	self	self	NOUN
admet-2214	226	2	assembly	assembly	NOUN
admet-2214	226	3	morphology	morphology	NOUN
admet-2214	226	4	done	do	VERB
admet-2214	226	5	by	by	ADP
admet-2214	226	6	afm	afm	PROPN
admet-2214	226	7	,	,	PUNCT
admet-2214	226	8	sem	sem	NOUN
admet-2214	226	9	and	and	CCONJ
admet-2214	226	10	tem	tem	PROPN
admet-2214	226	11	,	,	PUNCT
admet-2214	226	12	hydrodynamic	hydrodynamic	ADJ
admet-2214	226	13	diameter	diameter	NOUN
admet-2214	226	14	(	(	PUNCT
admet-2214	226	15	z	z	NOUN
admet-2214	226	16	average	average	NOUN
admet-2214	226	17	,	,	PUNCT
admet-2214	226	18	nm	nm	NOUN
admet-2214	226	19	)	)	PUNCT
admet-2214	226	20	,	,	PUNCT
admet-2214	226	21	polydispersity	polydispersity	NOUN
admet-2214	226	22	index	index	NOUN
admet-2214	226	23	(	(	PUNCT
admet-2214	226	24	pdi	pdi	PROPN
admet-2214	226	25	)	)	PUNCT
admet-2214	226	26	and	and	CCONJ
admet-2214	226	27	zeta	zeta	NOUN
admet-2214	226	28	potential	potential	NOUN
admet-2214	226	29	,	,	PUNCT
admet-2214	226	30	d	d	X
admet-2214	226	31	rug	rug	NOUN
admet-2214	226	32	loading	loading	NOUN
admet-2214	226	33	and	and	CCONJ
admet-2214	226	34	entrapment	entrapment	ADJ
admet-2214	226	35	efficiency	efficiency	NOUN
admet-2214	226	36	,	,	PUNCT
admet-2214	226	37	in	in	ADP
admet-2214	226	38	vitro	vitro	X
admet-2214	226	39	drug	drug	NOUN
admet-2214	226	40	release	release	NOUN
admet-2214	226	41	,	,	PUNCT
admet-2214	226	42	in	in	ADP
admet-2214	226	43	vitro	vitro	X
admet-2214	226	44	cell	cell	NOUN
admet-2214	226	45	culture	culture	NOUN
admet-2214	226	46	study	study	NOUN
admet-2214	226	47	,	,	PUNCT
admet-2214	226	48	in	in	ADP
admet-2214	226	49	vitro	vitro	X
admet-2214	226	50	tube	tube	NOUN
admet-2214	226	51	formation	formation	NOUN
admet-2214	226	52	study	study	NOUN
admet-2214	226	53	,	,	PUNCT
admet-2214	226	54	hemolysis	hemolysis	NOUN
admet-2214	226	55	test	test	NOUN
admet-2214	226	56	,	,	PUNCT
admet-2214	226	57	glioma	glioma	NOUN
admet-2214	226	58	models	model	NOUN
admet-2214	226	59	,	,	PUNCT
admet-2214	226	60	scintigraphic	scintigraphic	ADJ
admet-2214	226	61	imaging	imaging	NOUN
admet-2214	226	62	studies	study	NOUN
admet-2214	226	63	,	,	PUNCT
admet-2214	226	64	in	in	ADP
admet-2214	226	65	vivo	vivo	ADJ
admet-2214	226	66	anti	anti	ADJ
admet-2214	226	67	-	-	ADJ
admet-2214	226	68	tumor	tumor	ADJ
admet-2214	226	69	efficacy	efficacy	NOUN
admet-2214	226	70	assay	assay	VERB
admet-2214	226	71	,	,	PUNCT
admet-2214	226	72	in	in	ADP
admet-2214	226	73	vivo	vivo	ADJ
admet-2214	226	74	antiangiogenic	antiangiogenic	NOUN
admet-2214	226	75	,	,	PUNCT
admet-2214	226	76	antiproliferative	antiproliferative	NOUN
admet-2214	226	77	,	,	PUNCT
admet-2214	226	78	and	and	CCONJ
admet-2214	226	79	antiglioma	antiglioma	NOUN
admet-2214	226	80	activity	activity	NOUN
admet-2214	226	81	.	.	PUNCT
admet-2214	227	1	the	the	DET
admet-2214	227	2	findings	finding	NOUN
admet-2214	227	3	of	of	ADP
admet-2214	227	4	this	this	DET
admet-2214	227	5	study	study	NOUN
admet-2214	227	6	hold	hold	VERB
admet-2214	227	7	significant	significant	ADJ
admet-2214	227	8	potential	potential	NOUN
admet-2214	227	9	for	for	ADP
admet-2214	227	10	guiding	guide	VERB
admet-2214	227	11	the	the	DET
admet-2214	227	12	development	development	NOUN
admet-2214	227	13	of	of	ADP
admet-2214	227	14	future	future	ADJ
admet-2214	227	15	dds	dds	PROPN
admet-2214	227	16	designs	design	NOUN
admet-2214	227	17	.	.	PUNCT
admet-2214	228	1	specifically	specifically	ADV
admet-2214	228	2	,	,	PUNCT
admet-2214	228	3	the	the	DET
admet-2214	228	4	utilization	utilization	NOUN
admet-2214	228	5	of	of	ADP
admet-2214	228	6	diverse	diverse	ADJ
admet-2214	228	7	somatostatin	somatostatin	NOUN
admet-2214	228	8	analogs	analog	NOUN
admet-2214	228	9	,	,	PUNCT
admet-2214	228	10	including	include	VERB
admet-2214	228	11	but	but	CCONJ
admet-2214	228	12	not	not	PART
admet-2214	228	13	limited	limit	VERB
admet-2214	228	14	to	to	ADP
admet-2214	228	15	tyr-3	tyr-3	ADV
admet-2214	228	16	-	-	PUNCT
admet-2214	228	17	octreotate	octreotate	NOUN
admet-2214	228	18	,	,	PUNCT
admet-2214	228	19	which	which	PRON
admet-2214	228	20	exhibit	exhibit	VERB
admet-2214	228	21	a	a	DET
admet-2214	228	22	heightened	heightened	ADJ
admet-2214	228	23	affinity	affinity	NOUN
admet-2214	228	24	for	for	ADP
admet-2214	228	25	sstr2	sstr2	NOUN
admet-2214	228	26	,	,	PUNCT
admet-2214	228	27	could	could	AUX
admet-2214	228	28	be	be	AUX
admet-2214	228	29	explored	explore	VERB
admet-2214	228	30	.	.	PUNCT
admet-2214	229	1	such	such	DET
admet-2214	229	2	an	an	DET
admet-2214	229	3	approach	approach	NOUN
admet-2214	229	4	may	may	AUX
admet-2214	229	5	pave	pave	VERB
admet-2214	229	6	the	the	DET
admet-2214	229	7	way	way	NOUN
admet-2214	229	8	for	for	ADP
admet-2214	229	9	enhanced	enhanced	ADJ
admet-2214	229	10	therapeutic	therapeutic	ADJ
admet-2214	229	11	outcomes	outcome	NOUN
admet-2214	229	12	in	in	ADP
admet-2214	229	13	the	the	DET
admet-2214	229	14	field	field	NOUN
admet-2214	229	15	of	of	ADP
admet-2214	229	16	dds	dds	PROPN
admet-2214	229	17	.	.	PUNCT
admet-2214	230	1	zidovudine	zidovudine	PROPN
admet-2214	231	1	[	[	X
admet-2214	231	2	86	86	NUM
admet-2214	231	3	]	]	PUNCT
admet-2214	231	4	solid	solid	ADJ
admet-2214	231	5	lipid	lipid	NOUN
admet-2214	231	6	nanoparticles	nanoparticle	NOUN
admet-2214	231	7	stearic	stearic	ADJ
admet-2214	231	8	acid	acid	NOUN
admet-2214	231	9	,	,	PUNCT
admet-2214	231	10	polyvinyl	polyvinyl	NOUN
admet-2214	231	11	alcohol	alcohol	NOUN
admet-2214	231	12	,	,	PUNCT
admet-2214	231	13	aloevera	aloevera	NOUN
admet-2214	231	14	gel	gel	NOUN
admet-2214	231	15	,	,	PUNCT
admet-2214	231	16	mtt	mtt	NOUN
admet-2214	231	17	,	,	PUNCT
admet-2214	231	18	polyethyleneimine	polyethyleneimine	NOUN
admet-2214	231	19	,	,	PUNCT
admet-2214	231	20	trypsin	trypsin	NOUN
admet-2214	231	21	.	.	PUNCT
admet-2214	232	1	this	this	DET
admet-2214	232	2	study	study	NOUN
admet-2214	232	3	develops	develop	VERB
admet-2214	232	4	aloe	aloe	PROPN
admet-2214	232	5	vera	vera	NOUN
admet-2214	232	6	-	-	PUNCT
admet-2214	232	7	modified	modify	VERB
admet-2214	232	8	stearic	stearic	ADJ
admet-2214	232	9	acid	acid	NOUN
admet-2214	232	10	solid	solid	ADJ
admet-2214	232	11	lipid	lipid	NOUN
admet-2214	232	12	nanoparticles	nanoparticle	NOUN
admet-2214	232	13	(	(	PUNCT
admet-2214	232	14	slns	slns	NOUN
admet-2214	232	15	)	)	PUNCT
admet-2214	232	16	.	.	PUNCT
admet-2214	233	1	zidovudine	zidovudine	PROPN
admet-2214	233	2	,	,	PUNCT
admet-2214	233	3	a	a	DET
admet-2214	233	4	common	common	ADJ
admet-2214	233	5	antiretroviral	antiretroviral	ADJ
admet-2214	233	6	,	,	PUNCT
admet-2214	233	7	was	be	AUX
admet-2214	233	8	put	put	VERB
admet-2214	233	9	into	into	ADP
admet-2214	233	10	these	these	DET
admet-2214	233	11	slns	slns	NOUN
admet-2214	233	12	.	.	PUNCT
admet-2214	234	1	the	the	DET
admet-2214	234	2	simple	simple	ADJ
admet-2214	234	3	and	and	CCONJ
admet-2214	234	4	successful	successful	ADJ
admet-2214	234	5	emulsion	emulsion	NOUN
admet-2214	234	6	solvent	solvent	NOUN
admet-2214	234	7	evaporation	evaporation	NOUN
admet-2214	234	8	method	method	NOUN
admet-2214	234	9	was	be	AUX
admet-2214	234	10	used	use	VERB
admet-2214	234	11	to	to	PART
admet-2214	234	12	make	make	VERB
admet-2214	234	13	these	these	DET
admet-2214	234	14	slns	slns	NOUN
admet-2214	234	15	.	.	PUNCT
admet-2214	235	1	these	these	DET
admet-2214	235	2	slns	slns	NOUN
admet-2214	235	3	were	be	AUX
admet-2214	235	4	durable	durable	ADJ
admet-2214	235	5	at	at	ADP
admet-2214	235	6	ambient	ambient	ADJ
admet-2214	235	7	temperature	temperature	NOUN
admet-2214	235	8	and	and	CCONJ
admet-2214	235	9	in	in	ADP
admet-2214	235	10	a	a	DET
admet-2214	235	11	refrigerated	refrigerate	VERB
admet-2214	235	12	environment	environment	NOUN
admet-2214	235	13	.	.	PUNCT
admet-2214	236	1	this	this	PRON
admet-2214	236	2	suggests	suggest	VERB
admet-2214	236	3	that	that	SCONJ
admet-2214	236	4	slns	slns	NOUN
admet-2214	236	5	could	could	AUX
admet-2214	236	6	deliver	deliver	VERB
admet-2214	236	7	drugs	drug	NOUN
admet-2214	236	8	reliably	reliably	ADV
admet-2214	236	9	.	.	PUNCT
admet-2214	237	1	overall	overall	ADV
admet-2214	237	2	,	,	PUNCT
admet-2214	237	3	this	this	DET
admet-2214	237	4	study	study	NOUN
admet-2214	237	5	advances	advance	VERB
admet-2214	237	6	nanotechnology	nanotechnology	NOUN
admet-2214	237	7	by	by	ADP
admet-2214	237	8	developing	develop	VERB
admet-2214	237	9	slns	slns	ADJ
admet-2214	237	10	utilizing	utilize	VERB
admet-2214	237	11	stearic	stearic	ADJ
admet-2214	237	12	acid	acid	NOUN
admet-2214	237	13	modified	modify	VERB
admet-2214	237	14	with	with	ADP
admet-2214	237	15	aloe	aloe	PROPN
admet-2214	237	16	vera	vera	NOUN
admet-2214	237	17	.	.	PUNCT
admet-2214	238	1	zidovudine	zidovudine	PROPN
admet-2214	238	2	's	's	PART
admet-2214	238	3	encapsulation	encapsulation	NOUN
admet-2214	238	4	and	and	CCONJ
admet-2214	238	5	stability	stability	NOUN
admet-2214	238	6	in	in	ADP
admet-2214	238	7	these	these	DET
admet-2214	238	8	slns	slns	NOUN
admet-2214	238	9	enable	enable	ADJ
admet-2214	238	10	new	new	ADJ
admet-2214	238	11	delivery	delivery	NOUN
admet-2214	238	12	methods	method	NOUN
admet-2214	238	13	for	for	ADP
admet-2214	238	14	this	this	DET
admet-2214	238	15	antiretroviral	antiretroviral	ADJ
admet-2214	238	16	medication	medication	NOUN
admet-2214	238	17	.	.	PUNCT
admet-2214	239	1	emulsion	emulsion	NOUN
admet-2214	239	2	solvent	solvent	NOUN
admet-2214	239	3	evaporation	evaporation	NOUN
admet-2214	239	4	the	the	DET
admet-2214	239	5	hydrodynamic	hydrodynamic	ADJ
admet-2214	239	6	size	size	NOUN
admet-2214	239	7	,	,	PUNCT
admet-2214	239	8	zeta	zeta	NOUN
admet-2214	239	9	potential	potential	NOUN
admet-2214	239	10	,	,	PUNCT
admet-2214	239	11	tem	tem	PROPN
admet-2214	239	12	,	,	PUNCT
admet-2214	239	13	entrapment	entrapment	ADJ
admet-2214	239	14	efficiency	efficiency	NOUN
admet-2214	239	15	and	and	CCONJ
admet-2214	239	16	drug	drug	NOUN
admet-2214	239	17	loading	loading	NOUN
admet-2214	239	18	,	,	PUNCT
admet-2214	239	19	blood	blood	NOUN
admet-2214	239	20	compatibility	compatibility	NOUN
admet-2214	239	21	studies	study	NOUN
admet-2214	239	22	,	,	PUNCT
admet-2214	239	23	drug	drug	NOUN
admet-2214	239	24	release	release	NOUN
admet-2214	239	25	,	,	PUNCT
admet-2214	239	26	cell	cell	NOUN
admet-2214	239	27	culture	culture	NOUN
admet-2214	239	28	studies	study	NOUN
admet-2214	239	29	,	,	PUNCT
admet-2214	239	30	in	in	ADP
admet-2214	239	31	-	-	PUNCT
admet-2214	239	32	vitro	vitro	X
admet-2214	239	33	cytotoxicity	cytotoxicity	NOUN
admet-2214	239	34	studies	study	NOUN
admet-2214	239	35	,	,	PUNCT
admet-2214	239	36	in	in	ADP
admet-2214	239	37	vitro	vitro	X
admet-2214	239	38	cellular	cellular	ADJ
admet-2214	239	39	uptake	uptake	ADJ
admet-2214	239	40	studies	study	NOUN
admet-2214	239	41	.	.	PUNCT
admet-2214	240	1	according	accord	VERB
admet-2214	240	2	to	to	ADP
admet-2214	240	3	the	the	DET
admet-2214	240	4	cellular	cellular	ADJ
admet-2214	240	5	absorption	absorption	NOUN
admet-2214	240	6	investigation	investigation	NOUN
admet-2214	240	7	,	,	PUNCT
admet-2214	240	8	these	these	DET
admet-2214	240	9	nanoparticles	nanoparticle	NOUN
admet-2214	240	10	may	may	AUX
admet-2214	240	11	improve	improve	VERB
admet-2214	240	12	brain	brain	NOUN
admet-2214	240	13	cell	cell	NOUN
admet-2214	240	14	uptake	uptake	NOUN
admet-2214	240	15	of	of	ADP
admet-2214	240	16	antiviral	antiviral	ADJ
admet-2214	240	17	drugs	drug	NOUN
admet-2214	240	18	and	and	CCONJ
admet-2214	240	19	be	be	AUX
admet-2214	240	20	a	a	DET
admet-2214	240	21	good	good	ADJ
admet-2214	240	22	drug	drug	NOUN
admet-2214	240	23	carrier	carrier	NOUN
admet-2214	240	24	system	system	NOUN
admet-2214	240	25	for	for	ADP
admet-2214	240	26	glioma	glioma	ADJ
admet-2214	240	27	treatment	treatment	NOUN
admet-2214	240	28	.	.	PUNCT
admet-2214	241	1	nutlin	nutlin	PROPN
admet-2214	241	2	[	[	X
admet-2214	241	3	87	87	NUM
admet-2214	241	4	]	]	PUNCT
admet-2214	241	5	magnetic	magnetic	ADJ
admet-2214	241	6	solid	solid	ADJ
admet-2214	241	7	lipid	lipid	NOUN
admet-2214	241	8	nanoparticles	nanoparticle	NOUN
admet-2214	241	9	cetyl	cetyl	NOUN
admet-2214	241	10	palmitate	palmitate	NOUN
admet-2214	241	11	,	,	PUNCT
admet-2214	241	12	ethylene	ethylene	NOUN
admet-2214	241	13	glycol	glycol	NOUN
admet-2214	241	14	,	,	PUNCT
admet-2214	241	15	the	the	DET
admet-2214	241	16	aim	aim	NOUN
admet-2214	241	17	of	of	ADP
admet-2214	241	18	this	this	DET
admet-2214	241	19	study	study	NOUN
admet-2214	241	20	was	be	AUX
admet-2214	241	21	to	to	PART
admet-2214	241	22	develop	develop	VERB
admet-2214	241	23	and	and	CCONJ
admet-2214	241	24	evaluate	evaluate	VERB
admet-2214	241	25	solid	solid	ADJ
admet-2214	241	26	lipid	lipid	NOUN
admet-2214	241	27	nanoparticles	nanoparticle	NOUN
admet-2214	241	28	loaded	load	VERB
admet-2214	241	29	with	with	ADP
admet-2214	241	30	nutlin	nutlin	NOUN
admet-2214	241	31	for	for	ADP
admet-2214	241	32	treatment	treatment	NOUN
admet-2214	241	33	of	of	ADP
admet-2214	241	34	glioblastoma	glioblastoma	NOUN
admet-2214	241	35	.	.	PUNCT
admet-2214	242	1	solvent	solvent	ADJ
admet-2214	242	2	evaporation	evaporation	NOUN
admet-2214	242	3	technique	technique	NOUN
admet-2214	242	4	.	.	PUNCT
admet-2214	243	1	zeta	zeta	PROPN
admet-2214	243	2	potential	potential	NOUN
admet-2214	243	3	,	,	PUNCT
admet-2214	243	4	sem	sem	PROPN
admet-2214	243	5	,	,	PUNCT
admet-2214	243	6	tem	tem	PROPN
admet-2214	243	7	,	,	PUNCT
admet-2214	243	8	encapsulation	encapsulation	NOUN
admet-2214	243	9	efficiency	efficiency	NOUN
admet-2214	243	10	and	and	CCONJ
admet-2214	243	11	drug	drug	NOUN
admet-2214	243	12	loading	loading	NOUN
admet-2214	243	13	,	,	PUNCT
admet-2214	243	14	in	in	ADP
admet-2214	243	15	-	-	PUNCT
admet-2214	243	16	vitro	vitro	X
admet-2214	243	17	release	release	NOUN
admet-2214	243	18	,	,	PUNCT
admet-2214	243	19	cell	cell	NOUN
admet-2214	243	20	culture	culture	NOUN
admet-2214	243	21	,	,	PUNCT
admet-2214	243	22	static	static	ADJ
admet-2214	243	23	in	in	ADV
admet-2214	243	24	vitro	vitro	X
admet-2214	243	25	blood	blood	NOUN
admet-2214	243	26	-	-	PUNCT
admet-2214	243	27	brain	brain	NOUN
admet-2214	243	28	barrier	barrier	NOUN
admet-2214	243	29	model	model	NOUN
admet-2214	243	30	,	,	PUNCT
admet-2214	243	31	bbb	bbb	PROPN
admet-2214	243	32	crossing	crossing	NOUN
admet-2214	243	33	investigation	investigation	NOUN
admet-2214	243	34	,	,	PUNCT
admet-2214	243	35	nut	nut	NOUN
admet-2214	243	36	-	-	PUNCT
admet-2214	243	37	mag	mag	NOUN
admet-2214	243	38	-	-	PUNCT
admet-2214	243	39	slns	slns	NOUN
admet-2214	243	40	had	have	VERB
admet-2214	243	41	great	great	ADJ
admet-2214	243	42	colloidal	colloidal	NOUN
admet-2214	243	43	stability	stability	NOUN
admet-2214	243	44	,	,	PUNCT
admet-2214	243	45	stronger	strong	ADJ
admet-2214	243	46	pro	pro	ADJ
admet-2214	243	47	-	-	ADJ
admet-2214	243	48	apoptotic	apoptotic	ADJ
admet-2214	243	49	activity	activity	NOUN
admet-2214	243	50	against	against	ADP
admet-2214	243	51	glioblastoma	glioblastoma	NOUN
admet-2214	243	52	cells	cell	NOUN
admet-2214	243	53	than	than	ADP
admet-2214	243	54	the	the	DET
admet-2214	243	55	free	free	ADJ
admet-2214	243	56	drug	drug	NOUN
admet-2214	243	57	,	,	PUNCT
admet-2214	243	58	and	and	CCONJ
admet-2214	243	59	the	the	DET
admet-2214	243	60	ability	ability	NOUN
admet-2214	243	61	to	to	PART
admet-2214	243	62	cross	cross	VERB
admet-2214	243	63	the	the	DET
admet-2214	243	64	bloodbrain	bloodbrain	NOUN
admet-2214	243	65	barrier	barrier	NOUN
admet-2214	243	66	.	.	PUNCT
admet-2214	244	1	nut	nut	NOUN
admet-2214	244	2	-	-	PUNCT
admet-2214	244	3	mag	mag	NOUN
admet-2214	244	4	-	-	PUNCT
admet-2214	244	5	slns	slns	NOUN
admet-2214	244	6	are	be	AUX
admet-2214	244	7	promising	promise	VERB
admet-2214	244	8	multifunctional	multifunctional	ADJ
admet-2214	244	9	nanoplatforms	nanoplatform	NOUN
admet-2214	244	10	for	for	ADP
admet-2214	244	11	glioblastoma	glioblastoma	NOUN
admet-2214	244	12	multiforme	multiforme	NOUN
admet-2214	244	13	treatment	treatment	NOUN
admet-2214	244	14	.	.	PUNCT
admet-2214	245	1	role	role	NOUN
admet-2214	245	2	of	of	ADP
admet-2214	245	3	nano	nano	NOUN
admet-2214	245	4	lipid	lipid	NOUN
admet-2214	245	5	carriers	carrier	NOUN
admet-2214	245	6	in	in	ADP
admet-2214	245	7	dipg	dipg	NOUN
admet-2214	245	8	through	through	ADP
admet-2214	245	9	the	the	DET
admet-2214	245	10	substitution	substitution	NOUN
admet-2214	245	11	of	of	ADP
admet-2214	245	12	fractional	fractional	ADJ
admet-2214	245	13	solid	solid	ADJ
admet-2214	245	14	lipid	lipid	NOUN
admet-2214	245	15	components	component	NOUN
admet-2214	245	16	of	of	ADP
admet-2214	245	17	solid	solid	ADJ
admet-2214	245	18	lipid	lipid	NOUN
admet-2214	245	19	nanoparticles	nanoparticle	NOUN
admet-2214	245	20	(	(	PUNCT
admet-2214	245	21	slns	slns	NOUN
admet-2214	245	22	)	)	PUNCT
admet-2214	245	23	with	with	ADP
admet-2214	245	24	liquid	liquid	ADJ
admet-2214	245	25	lipids	lipid	NOUN
admet-2214	245	26	,	,	PUNCT
admet-2214	245	27	the	the	DET
admet-2214	245	28	formulation	formulation	NOUN
admet-2214	245	29	of	of	ADP
admet-2214	245	30	nanostructured	nanostructure	VERB
admet-2214	245	31	lipid	lipid	NOUN
admet-2214	245	32	carriers	carrier	NOUN
admet-2214	245	33	(	(	PUNCT
admet-2214	245	34	nlcs	nlcs	PROPN
admet-2214	245	35	)	)	PUNCT
admet-2214	245	36	was	be	AUX
admet-2214	245	37	advanced	advanced	ADJ
admet-2214	245	38	.	.	PUNCT
admet-2214	246	1	this	this	DET
admet-2214	246	2	modification	modification	NOUN
admet-2214	246	3	allowed	allow	VERB
admet-2214	246	4	for	for	ADP
admet-2214	246	5	a	a	DET
admet-2214	246	6	larger	large	ADJ
admet-2214	246	7	drug	drug	NOUN
admet-2214	246	8	-	-	PUNCT
admet-2214	246	9	loading	loading	NOUN
admet-2214	246	10	capacity	capacity	NOUN
admet-2214	246	11	within	within	ADP
admet-2214	246	12	the	the	DET
admet-2214	246	13	nlcs	nlcs	NOUN
admet-2214	246	14	[	[	X
admet-2214	246	15	88	88	NUM
admet-2214	246	16	]	]	PUNCT
admet-2214	246	17	.	.	PUNCT
admet-2214	247	1	the	the	DET
admet-2214	247	2	nlc	nlc	PROPN
admet-2214	247	3	(	(	PUNCT
admet-2214	247	4	nanostructured	nanostructure	VERB
admet-2214	247	5	lipid	lipid	NOUN
admet-2214	247	6	carrier	carrier	NOUN
admet-2214	247	7	)	)	PUNCT
admet-2214	247	8	exhibits	exhibit	VERB
admet-2214	247	9	remarkable	remarkable	ADJ
admet-2214	247	10	benefits	benefit	NOUN
admet-2214	247	11	as	as	ADP
admet-2214	247	12	a	a	DET
admet-2214	247	13	drug	drug	NOUN
admet-2214	247	14	delivery	delivery	NOUN
admet-2214	247	15	system	system	NOUN
admet-2214	247	16	,	,	PUNCT
admet-2214	247	17	offering	offer	VERB
admet-2214	247	18	notable	notable	ADJ
admet-2214	247	19	advancements	advancement	NOUN
admet-2214	247	20	in	in	ADP
admet-2214	247	21	drug	drug	NOUN
admet-2214	247	22	retention	retention	NOUN
admet-2214	247	23	and	and	CCONJ
admet-2214	247	24	enhanced	enhance	VERB
admet-2214	247	25	drug	drug	NOUN
admet-2214	247	26	loading	loading	NOUN
admet-2214	247	27	capacity	capacity	NOUN
admet-2214	247	28	.	.	PUNCT
admet-2214	248	1	however	however	ADV
admet-2214	248	2	,	,	PUNCT
admet-2214	248	3	it	it	PRON
admet-2214	248	4	is	be	AUX
admet-2214	248	5	worth	worth	ADJ
admet-2214	248	6	noting	note	VERB
admet-2214	248	7	that	that	SCONJ
admet-2214	248	8	the	the	DET
admet-2214	248	9	limited	limited	ADJ
admet-2214	248	10	solubility	solubility	NOUN
admet-2214	248	11	of	of	ADP
admet-2214	248	12	medications	medication	NOUN
admet-2214	248	13	in	in	ADP
admet-2214	248	14	solid	solid	ADJ
admet-2214	248	15	lipids	lipids	ADJ
admet-2214	248	16	poses	pose	NOUN
admet-2214	248	17	a	a	DET
admet-2214	248	18	challenge	challenge	NOUN
admet-2214	248	19	,	,	PUNCT
admet-2214	248	20	resulting	result	VERB
admet-2214	248	21	in	in	ADP
admet-2214	248	22	a	a	DET
admet-2214	248	23	comparatively	comparatively	ADV
admet-2214	248	24	low	low	ADJ
admet-2214	248	25	encapsulation	encapsulation	NOUN
admet-2214	248	26	efficiency	efficiency	NOUN
admet-2214	248	27	(	(	PUNCT
admet-2214	248	28	ee	ee	PROPN
admet-2214	248	29	)	)	PUNCT
admet-2214	248	30	.	.	PUNCT
admet-2214	249	1	the	the	DET
admet-2214	249	2	induction	induction	NOUN
admet-2214	249	3	of	of	ADP
admet-2214	249	4	phase	phase	NOUN
admet-2214	249	5	separation	separation	NOUN
admet-2214	249	6	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	249	7	z.	z.	PROPN
admet-2214	249	8	presswala	presswala	PROPN
admet-2214	249	9	et	et	PROPN
admet-2214	249	10	al	al	PROPN
admet-2214	249	11	.	.	PROPN
admet-2214	249	12	admet	admet	PROPN
admet-2214	249	13	&	&	CCONJ
admet-2214	249	14	dmpk	dmpk	PROPN
admet-2214	249	15	12(3	12(3	PROPN
admet-2214	249	16	)	)	PUNCT
admet-2214	249	17	(	(	PUNCT
admet-2214	249	18	2024	2024	NUM
admet-2214	249	19	)	)	PUNCT
admet-2214	249	20	403	403	NUM
admet-2214	249	21	-	-	SYM
admet-2214	249	22	429	429	NUM
admet-2214	249	23	416	416	NUM
admet-2214	249	24	in	in	ADP
admet-2214	249	25	numerous	numerous	ADJ
admet-2214	249	26	nematic	nematic	ADJ
admet-2214	249	27	liquid	liquid	ADJ
admet-2214	249	28	crystals	crystal	NOUN
admet-2214	249	29	(	(	PUNCT
admet-2214	249	30	nlcs	nlcs	PROPN
admet-2214	249	31	)	)	PUNCT
admet-2214	249	32	is	be	AUX
admet-2214	249	33	achieved	achieve	VERB
admet-2214	249	34	by	by	ADP
admet-2214	249	35	the	the	DET
admet-2214	249	36	deliberate	deliberate	ADJ
admet-2214	249	37	combination	combination	NOUN
admet-2214	249	38	of	of	ADP
admet-2214	249	39	a	a	DET
admet-2214	249	40	solid	solid	ADJ
admet-2214	249	41	lipid	lipid	NOUN
admet-2214	249	42	with	with	ADP
admet-2214	249	43	a	a	DET
admet-2214	249	44	higher	high	ADJ
admet-2214	249	45	oil	oil	NOUN
admet-2214	249	46	concentration	concentration	NOUN
admet-2214	249	47	.	.	PUNCT
admet-2214	250	1	the	the	DET
admet-2214	250	2	solubility	solubility	NOUN
admet-2214	250	3	of	of	ADP
admet-2214	250	4	drugs	drug	NOUN
admet-2214	250	5	experiences	experience	VERB
admet-2214	250	6	a	a	DET
admet-2214	250	7	notable	notable	ADJ
admet-2214	250	8	increase	increase	NOUN
admet-2214	250	9	when	when	SCONJ
admet-2214	250	10	drug	drug	NOUN
admet-2214	250	11	-	-	PUNCT
admet-2214	250	12	encapsulated	encapsulate	VERB
admet-2214	250	13	oily	oily	ADJ
admet-2214	250	14	nano	nano	NOUN
admet-2214	250	15	compartments	compartment	NOUN
admet-2214	250	16	are	be	AUX
admet-2214	250	17	formed	form	VERB
admet-2214	250	18	.	.	PUNCT
admet-2214	251	1	this	this	DET
admet-2214	251	2	occurrence	occurrence	NOUN
admet-2214	251	3	holds	hold	VERB
admet-2214	251	4	the	the	DET
admet-2214	251	5	potential	potential	NOUN
admet-2214	251	6	to	to	PART
admet-2214	251	7	greatly	greatly	ADV
admet-2214	251	8	enhance	enhance	VERB
admet-2214	251	9	the	the	DET
admet-2214	251	10	drug	drug	NOUN
admet-2214	251	11	's	's	PART
admet-2214	251	12	encapsulation	encapsulation	NOUN
admet-2214	251	13	efficiency	efficiency	NOUN
admet-2214	251	14	[	[	X
admet-2214	251	15	89	89	NUM
admet-2214	251	16	]	]	PUNCT
admet-2214	251	17	.	.	PUNCT
admet-2214	252	1	nano	nano	NOUN
admet-2214	252	2	lipid	lipid	NOUN
admet-2214	252	3	carriers	carrier	NOUN
admet-2214	252	4	are	be	AUX
admet-2214	252	5	basically	basically	ADV
admet-2214	252	6	of	of	ADP
admet-2214	252	7	three	three	NUM
admet-2214	252	8	types	type	NOUN
admet-2214	252	9	,	,	PUNCT
admet-2214	252	10	which	which	PRON
admet-2214	252	11	are	be	AUX
admet-2214	252	12	named	name	VERB
admet-2214	252	13	as	as	ADP
admet-2214	252	14	(	(	PUNCT
admet-2214	252	15	i	i	NOUN
admet-2214	252	16	)	)	PUNCT
admet-2214	252	17	imperfect	imperfect	ADJ
admet-2214	252	18	type	type	NOUN
admet-2214	252	19	,	,	PUNCT
admet-2214	252	20	(	(	PUNCT
admet-2214	252	21	ii	ii	NOUN
admet-2214	252	22	)	)	PUNCT
admet-2214	252	23	amorphous	amorphous	ADJ
admet-2214	252	24	type	type	NOUN
admet-2214	252	25	and	and	CCONJ
admet-2214	252	26	(	(	PUNCT
admet-2214	252	27	iii	iii	NOUN
admet-2214	252	28	)	)	PUNCT
admet-2214	252	29	multiple	multiple	ADJ
admet-2214	252	30	oil	oil	NOUN
admet-2214	252	31	in	in	ADP
admet-2214	252	32	solid	solid	ADJ
admet-2214	252	33	fat	fat	NOUN
admet-2214	252	34	in	in	ADP
admet-2214	252	35	water	water	NOUN
admet-2214	252	36	type	type	NOUN
admet-2214	252	37	[	[	X
admet-2214	252	38	90	90	NUM
admet-2214	252	39	]	]	PUNCT
admet-2214	252	40	.	.	PUNCT
admet-2214	253	1	all	all	DET
admet-2214	253	2	the	the	DET
admet-2214	253	3	three	three	NUM
admet-2214	253	4	types	type	NOUN
admet-2214	253	5	have	have	AUX
admet-2214	253	6	been	be	AUX
admet-2214	253	7	explained	explain	VERB
admet-2214	253	8	in	in	ADP
admet-2214	253	9	figure	figure	NOUN
admet-2214	253	10	12	12	NUM
admet-2214	253	11	figure	figure	NOUN
admet-2214	253	12	12	12	NUM
admet-2214	253	13	.	.	PUNCT
admet-2214	254	1	the	the	DET
admet-2214	254	2	diagram	diagram	NOUN
admet-2214	254	3	illustrates	illustrate	VERB
admet-2214	254	4	three	three	NUM
admet-2214	254	5	distinct	distinct	ADJ
admet-2214	254	6	categories	category	NOUN
admet-2214	254	7	of	of	ADP
admet-2214	254	8	nano	nano	NOUN
admet-2214	254	9	lipid	lipid	NOUN
admet-2214	254	10	carriers	carrier	NOUN
admet-2214	254	11	.	.	PUNCT
admet-2214	255	1	nanolipid	nanolipid	ADJ
admet-2214	255	2	carriers	carrier	NOUN
admet-2214	255	3	are	be	AUX
admet-2214	255	4	prepared	prepare	VERB
admet-2214	255	5	using	use	VERB
admet-2214	255	6	the	the	DET
admet-2214	255	7	same	same	ADJ
admet-2214	255	8	methods	method	NOUN
admet-2214	255	9	as	as	ADP
admet-2214	255	10	solid	solid	ADJ
admet-2214	255	11	lipid	lipid	ADJ
admet-2214	255	12	nanoparticles	nanoparticle	NOUN
admet-2214	255	13	.	.	PUNCT
admet-2214	256	1	according	accord	VERB
admet-2214	256	2	to	to	ADP
admet-2214	256	3	the	the	DET
admet-2214	256	4	authors	author	NOUN
admet-2214	256	5	in	in	ADP
admet-2214	256	6	[	[	X
admet-2214	256	7	91	91	NUM
admet-2214	256	8	]	]	PUNCT
admet-2214	256	9	,	,	PUNCT
admet-2214	256	10	it	it	PRON
admet-2214	256	11	was	be	AUX
admet-2214	256	12	demonstrated	demonstrate	VERB
admet-2214	256	13	that	that	SCONJ
admet-2214	256	14	temozolamide	temozolamide	NOUN
admet-2214	256	15	(	(	PUNCT
admet-2214	256	16	tmz	tmz	NOUN
admet-2214	256	17	)	)	PUNCT
admet-2214	256	18	could	could	AUX
admet-2214	256	19	be	be	AUX
admet-2214	256	20	administered	administer	VERB
admet-2214	256	21	to	to	ADP
admet-2214	256	22	u87	u87	NOUN
admet-2214	256	23	mg	mg	PROPN
admet-2214	256	24	cells	cell	NOUN
admet-2214	256	25	more	more	ADV
admet-2214	256	26	successfully	successfully	ADV
admet-2214	256	27	through	through	ADP
admet-2214	256	28	nano	nano	NOUN
admet-2214	256	29	lipid	lipid	NOUN
admet-2214	256	30	carriers	carrier	NOUN
admet-2214	256	31	rather	rather	ADV
admet-2214	256	32	than	than	ADP
admet-2214	256	33	through	through	ADP
admet-2214	256	34	polymeric	polymeric	ADJ
admet-2214	256	35	nanoparticles	nanoparticle	NOUN
admet-2214	256	36	and	and	CCONJ
admet-2214	256	37	solid	solid	ADJ
admet-2214	256	38	lipid	lipid	NOUN
admet-2214	256	39	nanoparticles	nanoparticle	NOUN
admet-2214	256	40	when	when	SCONJ
admet-2214	256	41	they	they	PRON
admet-2214	256	42	were	be	AUX
admet-2214	256	43	created	create	VERB
admet-2214	256	44	.	.	PUNCT
admet-2214	257	1	the	the	DET
admet-2214	257	2	following	follow	VERB
admet-2214	257	3	table	table	NOUN
admet-2214	257	4	highlights	highlight	VERB
admet-2214	257	5	the	the	DET
admet-2214	257	6	preclinical	preclinical	ADJ
admet-2214	257	7	studies	study	NOUN
admet-2214	257	8	on	on	ADP
admet-2214	257	9	nano	nano	NOUN
admet-2214	257	10	lipid	lipid	NOUN
admet-2214	257	11	carriers	carrier	NOUN
admet-2214	257	12	conducted	conduct	VERB
admet-2214	257	13	in	in	ADP
admet-2214	257	14	dipg	dipg	NOUN
admet-2214	257	15	.	.	PUNCT
admet-2214	258	1	preclinical	preclinical	ADJ
admet-2214	258	2	studies	study	NOUN
admet-2214	258	3	of	of	ADP
admet-2214	258	4	nano	nano	NOUN
admet-2214	258	5	lipid	lipid	NOUN
admet-2214	258	6	carriers	carrier	NOUN
admet-2214	258	7	in	in	ADP
admet-2214	258	8	dipg	dipg	NOUN
admet-2214	258	9	are	be	AUX
admet-2214	258	10	illustrated	illustrate	VERB
admet-2214	258	11	in	in	ADP
admet-2214	258	12	table	table	NOUN
admet-2214	258	13	4	4	NUM
admet-2214	258	14	.	.	PUNCT
admet-2214	258	15	table	table	NOUN
admet-2214	258	16	4	4	NUM
admet-2214	258	17	.	.	PUNCT
admet-2214	258	18	preclinical	preclinical	ADJ
admet-2214	258	19	studies	study	NOUN
admet-2214	258	20	of	of	ADP
admet-2214	258	21	nano	nano	NOUN
admet-2214	258	22	lipid	lipid	NOUN
admet-2214	258	23	carriers	carrier	NOUN
admet-2214	258	24	in	in	ADP
admet-2214	258	25	dipg	dipg	NOUN
admet-2214	258	26	drug	drug	NOUN
admet-2214	258	27	formulation	formulation	NOUN
admet-2214	258	28	excipients	excipient	NOUN
admet-2214	258	29	overview	overview	VERB
admet-2214	258	30	method	method	NOUN
admet-2214	258	31	of	of	ADP
admet-2214	258	32	preparation	preparation	NOUN
admet-2214	258	33	evaluation	evaluation	NOUN
admet-2214	258	34	parameters	parameter	NOUN
admet-2214	258	35	outcome	outcome	VERB
admet-2214	258	36	temozolamide	temozolamide	INTJ
admet-2214	258	37	reservetol	reservetol	NOUN
admet-2214	259	1	[	[	X
admet-2214	259	2	92	92	NUM
admet-2214	259	3	]	]	PUNCT
admet-2214	259	4	nano	nano	NOUN
admet-2214	259	5	lipid	lipid	NOUN
admet-2214	259	6	carriers	carrier	NOUN
admet-2214	259	7	via	via	ADP
admet-2214	259	8	intranasal	intranasal	ADJ
admet-2214	259	9	route	route	PROPN
admet-2214	259	10	lactoferin	lactoferin	NOUN
admet-2214	259	11	the	the	DET
admet-2214	259	12	work	work	NOUN
admet-2214	259	13	's	's	PART
admet-2214	259	14	goal	goal	NOUN
admet-2214	259	15	was	be	AUX
admet-2214	259	16	to	to	PART
admet-2214	259	17	create	create	VERB
admet-2214	259	18	nlc	nlc	PROPN
admet-2214	259	19	co	co	VERB
admet-2214	259	20	-	-	VERB
admet-2214	259	21	loaded	load	VERB
admet-2214	259	22	with	with	ADP
admet-2214	259	23	resveratrol	resveratrol	NOUN
admet-2214	259	24	and	and	CCONJ
admet-2214	259	25	lactoferrin	lactoferrin	NOUN
admet-2214	259	26	conjugated	conjugate	VERB
admet-2214	259	27	temozolomide	temozolomide	NOUN
admet-2214	259	28	for	for	ADP
admet-2214	259	29	the	the	DET
admet-2214	259	30	treatment	treatment	NOUN
admet-2214	259	31	of	of	ADP
admet-2214	259	32	glioblastoma	glioblastoma	NOUN
admet-2214	259	33	via	via	ADP
admet-2214	259	34	intranasal	intranasal	ADJ
admet-2214	259	35	delivery	delivery	NOUN
admet-2214	259	36	for	for	ADP
admet-2214	259	37	brain	brain	NOUN
admet-2214	259	38	targeting	targeting	NOUN
admet-2214	259	39	.	.	PUNCT
admet-2214	260	1	not	not	PART
admet-2214	260	2	disclosed	disclose	VERB
admet-2214	260	3	particle	particle	NOUN
admet-2214	260	4	size	size	NOUN
admet-2214	260	5	,	,	PUNCT
admet-2214	260	6	transmittance	transmittance	NOUN
admet-2214	260	7	,	,	PUNCT
admet-2214	260	8	entrapment	entrapment	ADJ
admet-2214	260	9	efficiency	efficiency	NOUN
admet-2214	260	10	,	,	PUNCT
admet-2214	260	11	polydispersity	polydispersity	NOUN
admet-2214	260	12	index	index	PROPN
admet-2214	260	13	,	,	PUNCT
admet-2214	260	14	tem	tem	PROPN
admet-2214	260	15	,	,	PUNCT
admet-2214	260	16	sem	sem	PROPN
admet-2214	260	17	,	,	PUNCT
admet-2214	260	18	ex	ex	ADJ
admet-2214	260	19	-	-	ADJ
admet-2214	260	20	vivo	vivo	ADJ
admet-2214	260	21	permeation	permeation	NOUN
admet-2214	260	22	studies	study	NOUN
admet-2214	260	23	.	.	PUNCT
admet-2214	261	1	according	accord	VERB
admet-2214	261	2	to	to	ADP
admet-2214	261	3	ex	ex	ADJ
admet-2214	261	4	-	-	ADJ
admet-2214	261	5	vivo	vivo	ADJ
admet-2214	261	6	experiments	experiment	NOUN
admet-2214	261	7	on	on	ADP
admet-2214	261	8	permeation	permeation	NOUN
admet-2214	261	9	,	,	PUNCT
admet-2214	261	10	at	at	ADP
admet-2214	261	11	24	24	NUM
admet-2214	261	12	hours	hour	NOUN
admet-2214	261	13	,	,	PUNCT
admet-2214	261	14	the	the	DET
admet-2214	261	15	percentage	percentage	NOUN
admet-2214	261	16	of	of	ADP
admet-2214	261	17	resveratrol	resveratrol	NOUN
admet-2214	261	18	and	and	CCONJ
admet-2214	261	19	temozolomide	temozolomide	NOUN
admet-2214	261	20	that	that	PRON
admet-2214	261	21	permeated	permeate	VERB
admet-2214	261	22	was	be	AUX
admet-2214	261	23	76.43	76.43	NUM
admet-2214	261	24	%	%	NOUN
admet-2214	261	25	,	,	PUNCT
admet-2214	261	26	88.55	88.55	NUM
admet-2214	261	27	%	%	NOUN
admet-2214	261	28	from	from	ADP
admet-2214	261	29	ltr	ltr	PROPN
admet-2214	261	30	-	-	PUNCT
admet-2214	261	31	nlc	nlc	PROPN
admet-2214	261	32	,	,	PUNCT
admet-2214	261	33	and	and	CCONJ
admet-2214	261	34	25.76	25.76	NUM
admet-2214	261	35	and	and	CCONJ
admet-2214	261	36	31.10	31.10	NUM
admet-2214	261	37	%	%	NOUN
admet-2214	261	38	from	from	ADP
admet-2214	261	39	suspension	suspension	NOUN
admet-2214	261	40	,	,	PUNCT
admet-2214	261	41	respecttively.based	respecttively.base	VERB
admet-2214	261	42	on	on	ADP
admet-2214	261	43	the	the	DET
admet-2214	261	44	results	result	NOUN
admet-2214	261	45	of	of	ADP
admet-2214	261	46	this	this	DET
admet-2214	261	47	study	study	NOUN
admet-2214	261	48	,	,	PUNCT
admet-2214	261	49	it	it	PRON
admet-2214	261	50	can	can	AUX
admet-2214	261	51	be	be	AUX
admet-2214	261	52	said	say	VERB
admet-2214	261	53	that	that	SCONJ
admet-2214	261	54	ltr	ltr	PROPN
admet-2214	261	55	-	-	PUNCT
admet-2214	261	56	nlc	nlc	PROPN
admet-2214	261	57	might	might	AUX
admet-2214	261	58	be	be	AUX
admet-2214	261	59	a	a	DET
admet-2214	261	60	useful	useful	ADJ
admet-2214	261	61	formulation	formulation	NOUN
admet-2214	261	62	for	for	ADP
admet-2214	261	63	the	the	DET
admet-2214	261	64	treatment	treatment	NOUN
admet-2214	261	65	of	of	ADP
admet-2214	261	66	glioblastoma	glioblastoma	NOUN
admet-2214	261	67	.	.	PUNCT
admet-2214	262	1	temozolamide	temozolamide	PROPN
admet-2214	263	1	[	[	X
admet-2214	263	2	91	91	NUM
admet-2214	263	3	]	]	PUNCT
admet-2214	263	4	polymeric	polymeric	ADJ
admet-2214	263	5	nanoparticles	nanoparticle	NOUN
admet-2214	263	6	,	,	PUNCT
admet-2214	263	7	solid	solid	ADJ
admet-2214	263	8	lipid	lipid	NOUN
admet-2214	263	9	nanoparticles	nanoparticle	NOUN
admet-2214	263	10	,	,	PUNCT
admet-2214	263	11	nano	nano	NOUN
admet-2214	263	12	lipid	lipid	NOUN
admet-2214	263	13	carriers	carrier	NOUN
admet-2214	263	14	.	.	PUNCT
admet-2214	264	1	stearic	stearic	ADJ
admet-2214	264	2	acid	acid	NOUN
admet-2214	264	3	,	,	PUNCT
admet-2214	264	4	poly(lactic	poly(lactic	PROPN
admet-2214	264	5	-	-	PUNCT
admet-2214	264	6	co	co	NOUN
admet-2214	264	7	-	-	ADJ
admet-2214	264	8	glycolic	glycolic	ADJ
admet-2214	264	9	acid	acid	NOUN
admet-2214	264	10	,	,	PUNCT
admet-2214	264	11	tween	tween	NOUN
admet-2214	264	12	80	80	NUM
admet-2214	264	13	,	,	PUNCT
admet-2214	264	14	polyvinyl	polyvinyl	NOUN
admet-2214	264	15	alcohol	alcohol	NOUN
admet-2214	264	16	,	,	PUNCT
admet-2214	264	17	soyabean	soyabean	ADJ
admet-2214	264	18	phosphotadylcholine	phosphotadylcholine	NOUN
admet-2214	264	19	,	,	PUNCT
admet-2214	264	20	injectable	injectable	ADJ
admet-2214	264	21	soyalecithin	soyalecithin	NOUN
admet-2214	264	22	,	,	PUNCT
admet-2214	264	23	polyoxyl	polyoxyl	NOUN
admet-2214	264	24	castor	castor	NOUN
admet-2214	264	25	oil	oil	NOUN
admet-2214	264	26	.	.	PUNCT
admet-2214	265	1	the	the	DET
admet-2214	265	2	delivery	delivery	NOUN
admet-2214	265	3	of	of	ADP
admet-2214	265	4	temozolomide	temozolomide	NOUN
admet-2214	265	5	(	(	PUNCT
admet-2214	265	6	tmz	tmz	NOUN
admet-2214	265	7	)	)	PUNCT
admet-2214	265	8	has	have	AUX
admet-2214	265	9	been	be	AUX
admet-2214	265	10	ingeniously	ingeniously	ADV
admet-2214	265	11	designed	design	VERB
admet-2214	265	12	to	to	PART
admet-2214	265	13	utilize	utilize	VERB
admet-2214	265	14	polymeric	polymeric	ADJ
admet-2214	265	15	nanoparticles	nanoparticle	NOUN
admet-2214	265	16	,	,	PUNCT
admet-2214	265	17	solid	solid	ADJ
admet-2214	265	18	lipid	lipid	NOUN
admet-2214	265	19	nanoparticles	nanoparticle	NOUN
admet-2214	265	20	,	,	PUNCT
admet-2214	265	21	and	and	CCONJ
admet-2214	265	22	nanostructured	nanostructure	VERB
admet-2214	265	23	lipid	lipid	NOUN
admet-2214	265	24	carriers	carrier	NOUN
admet-2214	265	25	.	.	PUNCT
admet-2214	266	1	these	these	DET
admet-2214	266	2	advanced	advanced	ADJ
admet-2214	266	3	delivery	delivery	NOUN
admet-2214	266	4	systems	system	NOUN
admet-2214	266	5	offer	offer	VERB
admet-2214	266	6	promising	promise	VERB
admet-2214	266	7	avenues	avenue	NOUN
admet-2214	266	8	for	for	ADP
admet-2214	266	9	enhancing	enhance	VERB
admet-2214	266	10	the	the	DET
admet-2214	266	11	therapeutic	therapeutic	ADJ
admet-2214	266	12	efficacy	efficacy	NOUN
admet-2214	266	13	of	of	ADP
admet-2214	266	14	tmz	tmz	PROPN
admet-2214	266	15	.	.	PUNCT
admet-2214	267	1	in	in	ADP
admet-2214	267	2	order	order	NOUN
admet-2214	267	3	to	to	PART
admet-2214	267	4	ascertain	ascertain	VERB
admet-2214	267	5	the	the	DET
admet-2214	267	6	most	most	ADV
admet-2214	267	7	suitable	suitable	ADJ
admet-2214	267	8	nanocarrier	nanocarrier	NOUN
admet-2214	267	9	for	for	ADP
admet-2214	267	10	the	the	DET
admet-2214	267	11	treatment	treatment	NOUN
admet-2214	267	12	of	of	ADP
admet-2214	267	13	gliomatosis	gliomatosis	NOUN
admet-2214	267	14	cerebri	cerebri	NOUN
admet-2214	267	15	,	,	PUNCT
admet-2214	267	16	an	an	DET
admet-2214	267	17	evaluation	evaluation	NOUN
admet-2214	267	18	was	be	AUX
admet-2214	267	19	conducted	conduct	VERB
admet-2214	267	20	to	to	PART
admet-2214	267	21	assess	assess	VERB
admet-2214	267	22	the	the	DET
admet-2214	267	23	anticancer	anticancer	NOUN
admet-2214	267	24	effects	effect	NOUN
admet-2214	267	25	of	of	ADP
admet-2214	267	26	three	three	NUM
admet-2214	267	27	distinct	distinct	ADJ
admet-2214	267	28	types	type	NOUN
admet-2214	267	29	.	.	PUNCT
admet-2214	268	1	t	t	X
admet-2214	268	2	-	-	PUNCT
admet-2214	268	3	pnps	pnps	PROPN
admet-2214	268	4	were	be	AUX
admet-2214	268	5	prepared	prepare	VERB
admet-2214	268	6	by	by	ADP
admet-2214	268	7	a	a	DET
admet-2214	268	8	solvent	solvent	ADJ
admet-2214	268	9	displacement	displacement	NOUN
admet-2214	268	10	technique	technique	NOUN
admet-2214	268	11	,	,	PUNCT
admet-2214	268	12	t	t	PROPN
admet-2214	268	13	-	-	PUNCT
admet-2214	268	14	slns	slns	PROPN
admet-2214	268	15	were	be	AUX
admet-2214	268	16	prepared	prepare	VERB
admet-2214	268	17	following	follow	VERB
admet-2214	268	18	the	the	DET
admet-2214	268	19	solvent	solvent	ADJ
admet-2214	268	20	displacement	displacement	NOUN
admet-2214	268	21	technique	technique	NOUN
admet-2214	268	22	,	,	PUNCT
admet-2214	268	23	t	t	PROPN
admet-2214	268	24	-	-	PUNCT
admet-2214	268	25	nlcs	nlcs	PROPN
admet-2214	268	26	were	be	AUX
admet-2214	268	27	prepared	prepare	VERB
admet-2214	268	28	by	by	ADP
admet-2214	268	29	solvent	solvent	ADJ
admet-2214	268	30	diffusion	diffusion	NOUN
admet-2214	268	31	method	method	NOUN
admet-2214	268	32	.	.	PUNCT
admet-2214	269	1	particle	particle	NOUN
admet-2214	269	2	size	size	NOUN
admet-2214	269	3	,	,	PUNCT
admet-2214	269	4	zeta	zeta	NOUN
admet-2214	269	5	potential	potential	NOUN
admet-2214	269	6	,	,	PUNCT
admet-2214	269	7	drug	drug	NOUN
admet-2214	269	8	encapsulation	encapsulation	NOUN
admet-2214	269	9	efficiency	efficiency	NOUN
admet-2214	269	10	(	(	PUNCT
admet-2214	269	11	ee	ee	PROPN
admet-2214	269	12	)	)	PUNCT
admet-2214	269	13	,	,	PUNCT
admet-2214	269	14	drug	drug	NOUN
admet-2214	269	15	loading	loading	NOUN
admet-2214	269	16	(	(	PUNCT
admet-2214	269	17	dl	dl	NOUN
admet-2214	269	18	)	)	PUNCT
admet-2214	269	19	capacity	capacity	NOUN
admet-2214	269	20	,	,	PUNCT
admet-2214	269	21	antitumor	antitumor	PROPN
admet-2214	269	22	efficacies	efficacy	NOUN
admet-2214	269	23	.	.	PUNCT
admet-2214	270	1	in	in	ADP
admet-2214	270	2	the	the	DET
admet-2214	270	3	realm	realm	NOUN
admet-2214	270	4	of	of	ADP
admet-2214	270	5	in	in	ADP
admet-2214	270	6	vivo	vivo	NOUN
admet-2214	270	7	and	and	CCONJ
admet-2214	270	8	in	in	ADP
admet-2214	270	9	vitro	vitro	X
admet-2214	270	10	experiments	experiment	NOUN
admet-2214	270	11	,	,	PUNCT
admet-2214	270	12	it	it	PRON
admet-2214	270	13	has	have	AUX
admet-2214	270	14	been	be	AUX
admet-2214	270	15	observed	observe	VERB
admet-2214	270	16	that	that	SCONJ
admet-2214	270	17	t	t	PROPN
admet-2214	270	18	-	-	PUNCT
admet-2214	270	19	nlcs	nlcs	PROPN
admet-2214	270	20	have	have	AUX
admet-2214	270	21	demonstrated	demonstrate	VERB
admet-2214	270	22	superior	superior	ADJ
admet-2214	270	23	performance	performance	NOUN
admet-2214	270	24	compared	compare	VERB
admet-2214	270	25	to	to	ADP
admet-2214	270	26	other	other	ADJ
admet-2214	270	27	formulations	formulation	NOUN
admet-2214	270	28	in	in	ADP
admet-2214	270	29	relation	relation	NOUN
admet-2214	270	30	to	to	ADP
admet-2214	270	31	their	their	PRON
admet-2214	270	32	anti	anti	ADJ
admet-2214	270	33	-	-	ADJ
admet-2214	270	34	tumor	tumor	ADJ
admet-2214	270	35	activity	activity	NOUN
admet-2214	270	36	.	.	PUNCT
admet-2214	271	1	the	the	DET
admet-2214	271	2	nlc	nlc	PROPN
admet-2214	271	3	formulations	formulation	NOUN
admet-2214	271	4	exhibited	exhibit	VERB
admet-2214	271	5	superior	superior	ADJ
admet-2214	271	6	glioma	glioma	NOUN
admet-2214	271	7	inhibition	inhibition	NOUN
admet-2214	271	8	in	in	ADP
admet-2214	271	9	comparison	comparison	NOUN
admet-2214	271	10	to	to	ADP
admet-2214	271	11	both	both	CCONJ
admet-2214	271	12	pnps	pnps	NOUN
admet-2214	271	13	and	and	CCONJ
admet-2214	271	14	slns	slns	NOUN
admet-2214	271	15	.	.	PUNCT
admet-2214	272	1	the	the	DET
admet-2214	272	2	findings	finding	NOUN
admet-2214	272	3	of	of	ADP
admet-2214	272	4	this	this	DET
admet-2214	272	5	study	study	NOUN
admet-2214	272	6	demonstrate	demonstrate	VERB
admet-2214	272	7	that	that	SCONJ
admet-2214	272	8	the	the	DET
admet-2214	272	9	delivery	delivery	NOUN
admet-2214	272	10	of	of	ADP
admet-2214	272	11	tmz	tmz	PROPN
admet-2214	272	12	to	to	ADP
admet-2214	272	13	u87	u87	NOUN
admet-2214	272	14	mg	mg	PROPN
admet-2214	272	15	cells	cell	NOUN
admet-2214	272	16	can	can	AUX
admet-2214	272	17	be	be	AUX
admet-2214	272	18	significantly	significantly	ADV
admet-2214	272	19	enhanced	enhance	VERB
admet-2214	272	20	through	through	ADP
admet-2214	272	21	the	the	DET
admet-2214	272	22	use	use	NOUN
admet-2214	272	23	of	of	ADP
admet-2214	272	24	nlcs	nlcs	NOUN
admet-2214	272	25	,	,	PUNCT
admet-2214	272	26	as	as	SCONJ
admet-2214	272	27	compared	compare	VERB
admet-2214	272	28	to	to	ADP
admet-2214	272	29	pnps	pnps	NOUN
admet-2214	272	30	or	or	CCONJ
admet-2214	272	31	slns	slns	NOUN
admet-2214	272	32	.	.	PUNCT
admet-2214	273	1	moreover	moreover	ADV
admet-2214	273	2	,	,	PUNCT
admet-2214	273	3	this	this	DET
admet-2214	273	4	enhanced	enhance	VERB
admet-2214	273	5	delivery	delivery	NOUN
admet-2214	273	6	method	method	NOUN
admet-2214	273	7	exhibits	exhibit	VERB
admet-2214	273	8	superior	superior	ADJ
admet-2214	273	9	inhibitory	inhibitory	ADJ
admet-2214	273	10	efficacy	efficacy	NOUN
admet-2214	273	11	.	.	PUNCT
admet-2214	274	1	the	the	DET
admet-2214	274	2	potential	potential	ADJ
admet-2214	274	3	utilization	utilization	NOUN
admet-2214	274	4	of	of	ADP
admet-2214	274	5	t	t	PROPN
admet-2214	274	6	-	-	PUNCT
admet-2214	274	7	nlcs	nlcs	PROPN
admet-2214	274	8	as	as	ADP
admet-2214	274	9	a	a	DET
admet-2214	274	10	promising	promising	ADJ
admet-2214	274	11	modality	modality	NOUN
admet-2214	274	12	for	for	ADP
admet-2214	274	13	delivering	deliver	VERB
admet-2214	274	14	chemotherapy	chemotherapy	NOUN
admet-2214	274	15	to	to	PART
admet-2214	274	16	treat	treat	VERB
admet-2214	274	17	glioblastoma	glioblastoma	NOUN
admet-2214	274	18	is	be	AUX
admet-2214	274	19	worth	worth	ADJ
admet-2214	274	20	exploring	explore	VERB
admet-2214	274	21	.	.	PUNCT
admet-2214	275	1	imperfect	imperfect	ADJ
admet-2214	275	2	type	type	NOUN
admet-2214	275	3	the	the	DET
admet-2214	275	4	structure	structure	NOUN
admet-2214	275	5	of	of	ADP
admet-2214	275	6	lipids	lipid	NOUN
admet-2214	275	7	in	in	ADP
admet-2214	275	8	this	this	DET
admet-2214	275	9	type	type	NOUN
admet-2214	275	10	is	be	AUX
admet-2214	275	11	known	know	VERB
admet-2214	275	12	to	to	PART
admet-2214	275	13	have	have	VERB
admet-2214	275	14	the	the	DET
admet-2214	275	15	potential	potential	NOUN
admet-2214	275	16	to	to	PART
admet-2214	275	17	distort	distort	VERB
admet-2214	275	18	crystal	crystal	NOUN
admet-2214	275	19	order	order	NOUN
admet-2214	275	20	.	.	PUNCT
admet-2214	276	1	the	the	DET
admet-2214	276	2	distortion	distortion	NOUN
admet-2214	276	3	in	in	ADP
admet-2214	276	4	question	question	NOUN
admet-2214	276	5	can	can	AUX
admet-2214	276	6	be	be	AUX
admet-2214	276	7	effectively	effectively	ADV
admet-2214	276	8	addressed	address	VERB
admet-2214	276	9	through	through	ADP
admet-2214	276	10	the	the	DET
admet-2214	276	11	manipulation	manipulation	NOUN
admet-2214	276	12	of	of	ADP
admet-2214	276	13	saturation	saturation	NOUN
admet-2214	276	14	levels	level	NOUN
admet-2214	276	15	and	and	CCONJ
admet-2214	276	16	the	the	DET
admet-2214	276	17	number	number	NOUN
admet-2214	276	18	of	of	ADP
admet-2214	276	19	carbon	carbon	NOUN
admet-2214	276	20	atoms	atom	NOUN
admet-2214	276	21	present	present	ADJ
admet-2214	276	22	in	in	ADP
admet-2214	276	23	lipids	lipid	NOUN
admet-2214	276	24	.	.	PUNCT
admet-2214	277	1	these	these	DET
admet-2214	277	2	modifications	modification	NOUN
admet-2214	277	3	have	have	VERB
admet-2214	277	4	the	the	DET
admet-2214	277	5	potential	potential	NOUN
admet-2214	277	6	to	to	PART
admet-2214	277	7	enhance	enhance	VERB
admet-2214	277	8	the	the	DET
admet-2214	277	9	drug	drug	NOUN
admet-2214	277	10	loading	loading	NOUN
admet-2214	277	11	capacity	capacity	NOUN
admet-2214	277	12	,	,	PUNCT
admet-2214	277	13	thereby	thereby	ADV
admet-2214	277	14	offering	offer	VERB
admet-2214	277	15	a	a	DET
admet-2214	277	16	promising	promising	ADJ
admet-2214	277	17	solution	solution	NOUN
admet-2214	277	18	.	.	PUNCT
admet-2214	278	1	amorphous	amorphous	ADJ
admet-2214	278	2	type	type	NOUN
admet-2214	278	3	in	in	ADP
admet-2214	278	4	this	this	DET
admet-2214	278	5	particular	particular	ADJ
admet-2214	278	6	formulation	formulation	NOUN
admet-2214	278	7	,	,	PUNCT
admet-2214	278	8	the	the	DET
admet-2214	278	9	incorporation	incorporation	NOUN
admet-2214	278	10	of	of	ADP
admet-2214	278	11	lipids	lipid	NOUN
admet-2214	278	12	such	such	ADJ
admet-2214	278	13	as	as	ADP
admet-2214	278	14	hydroxy	hydroxy	PROPN
admet-2214	278	15	octacosanyl	octacosanyl	NOUN
admet-2214	278	16	hydroxystearate	hydroxystearate	VERB
admet-2214	278	17	with	with	ADP
admet-2214	278	18	solid	solid	ADJ
admet-2214	278	19	lipids	lipids	ADJ
admet-2214	278	20	leads	lead	NOUN
admet-2214	278	21	to	to	ADP
admet-2214	278	22	the	the	DET
admet-2214	278	23	formation	formation	NOUN
admet-2214	278	24	of	of	ADP
admet-2214	278	25	nanostructured	nanostructure	VERB
admet-2214	278	26	lipid	lipid	NOUN
admet-2214	278	27	carriers	carrier	NOUN
admet-2214	278	28	(	(	PUNCT
admet-2214	278	29	nlcs	nlcs	PROPN
admet-2214	278	30	)	)	PUNCT
admet-2214	278	31	in	in	ADP
admet-2214	278	32	an	an	DET
admet-2214	278	33	amorphous	amorphous	ADJ
admet-2214	278	34	state	state	NOUN
admet-2214	278	35	.	.	PUNCT
admet-2214	279	1	this	this	DET
admet-2214	279	2	amorphous	amorphous	ADJ
admet-2214	279	3	structure	structure	NOUN
admet-2214	279	4	plays	play	VERB
admet-2214	279	5	a	a	DET
admet-2214	279	6	crucial	crucial	ADJ
admet-2214	279	7	role	role	NOUN
admet-2214	279	8	in	in	ADP
admet-2214	279	9	preventing	prevent	VERB
admet-2214	279	10	the	the	DET
admet-2214	279	11	expulsion	expulsion	NOUN
admet-2214	279	12	of	of	ADP
admet-2214	279	13	the	the	DET
admet-2214	279	14	drug	drug	NOUN
admet-2214	279	15	.	.	PUNCT
admet-2214	280	1	multiple	multiple	ADJ
admet-2214	280	2	oil	oil	NOUN
admet-2214	280	3	in	in	ADP
admet-2214	280	4	slid	slid	ADJ
admet-2214	280	5	fat	fat	ADJ
admet-2214	280	6	in	in	ADP
admet-2214	280	7	water	water	NOUN
admet-2214	280	8	type	type	NOUN
admet-2214	280	9	the	the	DET
admet-2214	280	10	specimen	speciman	NOUN
admet-2214	280	11	under	under	ADP
admet-2214	280	12	investigation	investigation	NOUN
admet-2214	280	13	exhibits	exhibit	VERB
admet-2214	280	14	a	a	DET
admet-2214	280	15	substantial	substantial	ADJ
admet-2214	280	16	presence	presence	NOUN
admet-2214	280	17	of	of	ADP
admet-2214	280	18	nanosized	nanosized	ADJ
admet-2214	280	19	oil	oil	NOUN
admet-2214	280	20	droplets	droplet	NOUN
admet-2214	280	21	that	that	PRON
admet-2214	280	22	are	be	AUX
admet-2214	280	23	uniformly	uniformly	ADV
admet-2214	280	24	distributed	distribute	VERB
admet-2214	280	25	within	within	ADP
admet-2214	280	26	the	the	DET
admet-2214	280	27	solid	solid	ADJ
admet-2214	280	28	matrix	matrix	NOUN
admet-2214	280	29	.	.	PUNCT
admet-2214	281	1	this	this	DET
admet-2214	281	2	unique	unique	ADJ
admet-2214	281	3	characteristic	characteristic	NOUN
admet-2214	281	4	leads	lead	VERB
admet-2214	281	5	to	to	ADP
admet-2214	281	6	enhanced	enhanced	ADJ
admet-2214	281	7	drug	drug	NOUN
admet-2214	281	8	loading	loading	NOUN
admet-2214	281	9	capacity	capacity	NOUN
admet-2214	281	10	and	and	CCONJ
admet-2214	281	11	an	an	DET
admet-2214	281	12	extended	extended	ADJ
admet-2214	281	13	release	release	NOUN
admet-2214	281	14	profile	profile	NOUN
admet-2214	281	15	of	of	ADP
admet-2214	281	16	the	the	DET
admet-2214	281	17	drug	drug	NOUN
admet-2214	281	18	.	.	PUNCT
admet-2214	282	1	admet	admet	PROPN
admet-2214	282	2	&	&	CCONJ
admet-2214	282	3	dmpk	dmpk	PROPN
admet-2214	282	4	12(3	12(3	PROPN
admet-2214	282	5	)	)	PUNCT
admet-2214	282	6	(	(	PUNCT
admet-2214	282	7	2024	2024	NUM
admet-2214	282	8	)	)	PUNCT
admet-2214	282	9	403	403	NUM
admet-2214	282	10	-	-	SYM
admet-2214	282	11	429	429	NUM
admet-2214	282	12	addressing	address	VERB
admet-2214	282	13	barriers	barrier	NOUN
admet-2214	282	14	in	in	ADP
admet-2214	282	15	diffuse	diffuse	ADJ
admet-2214	282	16	intrinsic	intrinsic	ADJ
admet-2214	282	17	pontine	pontine	ADJ
admet-2214	282	18	glioma	glioma	NOUN
admet-2214	282	19	doi	doi	NOUN
admet-2214	282	20	:	:	PUNCT
admet-2214	282	21	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	282	22	417	417	NUM
admet-2214	282	23	drug	drug	NOUN
admet-2214	282	24	formulation	formulation	NOUN
admet-2214	282	25	excipients	excipient	NOUN
admet-2214	282	26	overview	overview	VERB
admet-2214	282	27	method	method	NOUN
admet-2214	282	28	of	of	ADP
admet-2214	282	29	preparation	preparation	NOUN
admet-2214	282	30	evaluation	evaluation	NOUN
admet-2214	282	31	parameters	parameter	NOUN
admet-2214	282	32	outcome	outcome	VERB
admet-2214	282	33	docetaxel	docetaxel	NOUN
admet-2214	283	1	[	[	X
admet-2214	283	2	93	93	NUM
admet-2214	283	3	]	]	PUNCT
admet-2214	283	4	nano	nano	NOUN
admet-2214	283	5	lipid	lipid	NOUN
admet-2214	283	6	carriers	carrier	NOUN
admet-2214	283	7	propylene	propylene	NOUN
admet-2214	283	8	glycol	glycol	NOUN
admet-2214	283	9	monolaurate	monolaurate	NOUN
admet-2214	283	10	(	(	PUNCT
admet-2214	283	11	lauroglycol	lauroglycol	PROPN
admet-2214	283	12	90	90	NUM
admet-2214	283	13	)	)	PUNCT
admet-2214	283	14	,	,	PUNCT
admet-2214	283	15	capryolpropylene	capryolpropylene	ADJ
admet-2214	283	16	glycol	glycol	NOUN
admet-2214	283	17	monocarpylate	monocarpylate	NOUN
admet-2214	283	18	,	,	PUNCT
admet-2214	283	19	caprylocaproylmacrogol-8	caprylocaproylmacrogol-8	NOUN
admet-2214	283	20	-	-	PUNCT
admet-2214	283	21	glycerides	glyceride	NOUN
admet-2214	283	22	(	(	PUNCT
admet-2214	283	23	labrasol	labrasol	NOUN
admet-2214	283	24	)	)	PUNCT
admet-2214	283	25	,	,	PUNCT
admet-2214	283	26	polyoxyl15	polyoxyl15	NOUN
admet-2214	283	27	-	-	PUNCT
admet-2214	283	28	hydroxystearate	hydroxystearate	NOUN
admet-2214	283	29	(	(	PUNCT
admet-2214	283	30	kolliphor	kolliphor	NOUN
admet-2214	283	31	®	®	NOUN
admet-2214	283	32	hs15	hs15	PROPN
admet-2214	283	33	)	)	PUNCT
admet-2214	283	34	the	the	DET
admet-2214	283	35	primary	primary	ADJ
admet-2214	283	36	aim	aim	NOUN
admet-2214	283	37	of	of	ADP
admet-2214	283	38	this	this	DET
admet-2214	283	39	study	study	NOUN
admet-2214	283	40	was	be	AUX
admet-2214	283	41	to	to	PART
admet-2214	283	42	create	create	VERB
admet-2214	283	43	nano	nano	NOUN
admet-2214	283	44	lipid	lipid	NOUN
admet-2214	283	45	carriers	carrier	NOUN
admet-2214	283	46	of	of	ADP
admet-2214	283	47	docetaxel	docetaxel	NOUN
admet-2214	283	48	that	that	PRON
admet-2214	283	49	possess	possess	VERB
admet-2214	283	50	enhanced	enhanced	ADJ
admet-2214	283	51	permeation	permeation	NOUN
admet-2214	283	52	across	across	ADP
admet-2214	283	53	the	the	DET
admet-2214	283	54	blood	blood	NOUN
admet-2214	283	55	-	-	PUNCT
admet-2214	283	56	brain	brain	NOUN
admet-2214	283	57	barrier	barrier	NOUN
admet-2214	283	58	(	(	PUNCT
admet-2214	283	59	bbb	bbb	PROPN
admet-2214	283	60	)	)	PUNCT
admet-2214	283	61	.	.	PUNCT
admet-2214	284	1	this	this	PRON
admet-2214	284	2	was	be	AUX
admet-2214	284	3	achieved	achieve	VERB
admet-2214	284	4	by	by	ADP
admet-2214	284	5	investigating	investigate	VERB
admet-2214	284	6	the	the	DET
admet-2214	284	7	impact	impact	NOUN
admet-2214	284	8	of	of	ADP
admet-2214	284	9	four	four	NUM
admet-2214	284	10	different	different	ADJ
admet-2214	284	11	liquid	liquid	NOUN
admet-2214	284	12	lipids	lipid	NOUN
admet-2214	284	13	on	on	ADP
admet-2214	284	14	the	the	DET
admet-2214	284	15	carrier	carrier	NOUN
admet-2214	284	16	's	's	PART
admet-2214	284	17	efficacy	efficacy	NOUN
admet-2214	284	18	.	.	PUNCT
admet-2214	285	1	melt	melt	VERB
admet-2214	285	2	emulsification	emulsification	NOUN
admet-2214	285	3	method	method	NOUN
admet-2214	285	4	rem	rem	PROPN
admet-2214	285	5	,	,	PUNCT
admet-2214	285	6	sem	sem	NOUN
admet-2214	285	7	,	,	PUNCT
admet-2214	285	8	particle	particle	NOUN
admet-2214	285	9	size	size	NOUN
admet-2214	285	10	,	,	PUNCT
admet-2214	285	11	zeta	zeta	NOUN
admet-2214	285	12	potential	potential	NOUN
admet-2214	285	13	,	,	PUNCT
admet-2214	285	14	drug	drug	NOUN
admet-2214	285	15	entrapment	entrapment	ADJ
admet-2214	285	16	study	study	NOUN
admet-2214	285	17	,	,	PUNCT
admet-2214	285	18	permeation	permeation	NOUN
admet-2214	285	19	studies	study	NOUN
admet-2214	285	20	using	use	VERB
admet-2214	285	21	3d	3d	NUM
admet-2214	285	22	in	in	ADP
admet-2214	285	23	-	-	PUNCT
admet-2214	285	24	vitro	vitro	X
admet-2214	285	25	model	model	NOUN
admet-2214	285	26	.	.	PUNCT
admet-2214	286	1	in	in	ADP
admet-2214	286	2	a	a	DET
admet-2214	286	3	3d	3d	NOUN
admet-2214	286	4	in	in	ADP
admet-2214	286	5	-	-	PUNCT
admet-2214	286	6	vitro	vitro	X
admet-2214	286	7	model	model	NOUN
admet-2214	286	8	of	of	ADP
admet-2214	286	9	bbtb	bbtb	NOUN
admet-2214	286	10	/	/	SYM
admet-2214	286	11	gb	gb	PROPN
admet-2214	286	12	,	,	PUNCT
admet-2214	286	13	nlcs	nlcs	PROPN
admet-2214	286	14	showed	show	VERB
admet-2214	286	15	great	great	ADJ
admet-2214	286	16	permeability	permeability	NOUN
admet-2214	286	17	and	and	CCONJ
admet-2214	286	18	were	be	AUX
admet-2214	286	19	able	able	ADJ
admet-2214	286	20	to	to	PART
admet-2214	286	21	cross	cross	VERB
admet-2214	286	22	the	the	DET
admet-2214	286	23	blood	blood	NOUN
admet-2214	286	24	-	-	PUNCT
admet-2214	286	25	brain	brain	NOUN
admet-2214	286	26	tumor	tumor	NOUN
admet-2214	286	27	barrier	barrier	NOUN
admet-2214	286	28	(	(	PUNCT
admet-2214	286	29	bbtb	bbtb	NOUN
admet-2214	286	30	)	)	PUNCT
admet-2214	286	31	.	.	PUNCT
admet-2214	287	1	nlcs	nlcs	PROPN
admet-2214	287	2	then	then	ADV
admet-2214	287	3	accumulated	accumulate	VERB
admet-2214	287	4	in	in	ADP
admet-2214	287	5	glioblastoma	glioblastoma	NOUN
admet-2214	287	6	cells	cell	NOUN
admet-2214	287	7	.	.	PUNCT
admet-2214	288	1	patient	patient	NOUN
admet-2214	288	2	-	-	PUNCT
admet-2214	288	3	derived	derive	VERB
admet-2214	288	4	cells	cell	NOUN
admet-2214	288	5	absorbed	absorb	VERB
admet-2214	288	6	nlcs	nlcs	PROPN
admet-2214	288	7	2.4	2.4	NUM
admet-2214	288	8	times	time	NOUN
admet-2214	288	9	better	well	ADJ
admet-2214	288	10	than	than	ADP
admet-2214	288	11	u87	u87	NOUN
admet-2214	288	12	mg	mg	PROPN
admet-2214	288	13	cells	cell	NOUN
admet-2214	288	14	.	.	PUNCT
admet-2214	289	1	the	the	DET
admet-2214	289	2	authors	author	NOUN
admet-2214	289	3	give	give	VERB
admet-2214	289	4	a	a	DET
admet-2214	289	5	persuasive	persuasive	ADJ
admet-2214	289	6	view	view	NOUN
admet-2214	289	7	of	of	ADP
admet-2214	289	8	a	a	DET
admet-2214	289	9	prospective	prospective	ADJ
admet-2214	289	10	nanomedicine	nanomedicine	ADJ
admet-2214	289	11	technique	technique	NOUN
admet-2214	289	12	that	that	PRON
admet-2214	289	13	they	they	PRON
admet-2214	289	14	envision	envision	VERB
admet-2214	289	15	as	as	ADP
admet-2214	289	16	simple	simple	ADJ
admet-2214	289	17	and	and	CCONJ
admet-2214	289	18	commercially	commercially	ADV
admet-2214	289	19	viable	viable	ADJ
admet-2214	289	20	.	.	PUNCT
admet-2214	290	1	the	the	DET
admet-2214	290	2	approach	approach	NOUN
admet-2214	290	3	has	have	VERB
admet-2214	290	4	potential	potential	NOUN
admet-2214	290	5	for	for	ADP
admet-2214	290	6	further	further	ADJ
admet-2214	290	7	development	development	NOUN
admet-2214	290	8	and	and	CCONJ
admet-2214	290	9	investigation	investigation	NOUN
admet-2214	290	10	.	.	PUNCT
admet-2214	291	1	bortezomib	bortezomib	PROPN
admet-2214	292	1	[	[	X
admet-2214	292	2	94	94	NUM
admet-2214	292	3	]	]	PUNCT
admet-2214	292	4	nano	nano	NOUN
admet-2214	292	5	lipid	lipid	NOUN
admet-2214	292	6	carriers	carrier	NOUN
admet-2214	292	7	precirol	precirol	PROPN
admet-2214	292	8	ato	ato	PROPN
admet-2214	292	9	®	®	PROPN
admet-2214	292	10	5	5	NUM
admet-2214	292	11	,	,	PUNCT
admet-2214	292	12	glycerol	glycerol	NOUN
admet-2214	292	13	monooleate	monooleate	NOUN
admet-2214	292	14	,	,	PUNCT
admet-2214	292	15	coumarin	coumarin	NOUN
admet-2214	292	16	6	6	NUM
admet-2214	292	17	,	,	PUNCT
admet-2214	292	18	polyoxyethylene	polyoxyethylene	NOUN
admet-2214	292	19	(	(	PUNCT
admet-2214	292	20	10	10	NUM
admet-2214	292	21	)	)	PUNCT
admet-2214	292	22	cetyl	cetyl	NOUN
admet-2214	292	23	ether	ether	NOUN
admet-2214	292	24	,	,	PUNCT
admet-2214	292	25	mtt	mtt	PROPN
admet-2214	292	26	,	,	PUNCT
admet-2214	292	27	hematoxylin	hematoxylin	NOUN
admet-2214	292	28	and	and	CCONJ
admet-2214	292	29	eosin	eosin	NOUN
admet-2214	292	30	.	.	PUNCT
admet-2214	293	1	for	for	ADP
admet-2214	293	2	targeted	target	VERB
admet-2214	293	3	distribution	distribution	NOUN
admet-2214	293	4	,	,	PUNCT
admet-2214	293	5	nanostructured	nanostructure	VERB
admet-2214	293	6	lipid	lipid	NOUN
admet-2214	293	7	carriers	carrier	NOUN
admet-2214	293	8	were	be	AUX
admet-2214	293	9	loaded	load	VERB
admet-2214	293	10	with	with	ADP
admet-2214	293	11	two	two	NUM
admet-2214	293	12	proteolytically	proteolytically	ADV
admet-2214	293	13	stable	stable	ADJ
admet-2214	293	14	dpeptides	dpeptide	NOUN
admet-2214	293	15	,	,	PUNCT
admet-2214	293	16	d8	d8	ADJ
admet-2214	293	17	and	and	CCONJ
admet-2214	293	18	ri	ri	NOUN
admet-2214	293	19	-	-	PUNCT
admet-2214	293	20	vap	vap	NOUN
admet-2214	293	21	(	(	PUNCT
admet-2214	293	22	dual	dual	ADJ
admet-2214	293	23	nlcs	nlcs	NOUN
admet-2214	293	24	)	)	PUNCT
admet-2214	293	25	.	.	PUNCT
admet-2214	294	1	not	not	PART
admet-2214	294	2	disclosed	disclose	VERB
admet-2214	294	3	rem	rem	PROPN
admet-2214	294	4	,	,	PUNCT
admet-2214	294	5	sem	sem	NOUN
admet-2214	294	6	,	,	PUNCT
admet-2214	294	7	particle	particle	NOUN
admet-2214	294	8	size	size	NOUN
admet-2214	294	9	,	,	PUNCT
admet-2214	294	10	zeta	zeta	NOUN
admet-2214	294	11	potential	potential	NOUN
admet-2214	294	12	,	,	PUNCT
admet-2214	294	13	drug	drug	NOUN
admet-2214	294	14	entrapment	entrapment	NOUN
admet-2214	294	15	study	study	NOUN
admet-2214	294	16	,	,	PUNCT
admet-2214	294	17	in	in	ADP
admet-2214	294	18	-	-	PUNCT
admet-2214	294	19	vivo	vivo	NOUN
admet-2214	294	20	and	and	CCONJ
admet-2214	294	21	ex	ex	ADJ
admet-2214	294	22	-	-	ADJ
admet-2214	294	23	vivo	vivo	ADJ
admet-2214	294	24	animal	animal	NOUN
admet-2214	294	25	imaging	imaging	NOUN
admet-2214	294	26	,	,	PUNCT
admet-2214	294	27	in	in	ADP
admet-2214	294	28	-	-	PUNCT
admet-2214	294	29	vitro	vitro	X
admet-2214	294	30	cytotoxicity	cytotoxicity	NOUN
admet-2214	294	31	,	,	PUNCT
admet-2214	294	32	apoptosis	apoptosis	NOUN
admet-2214	294	33	.	.	PUNCT
admet-2214	295	1	dual	dual	ADJ
admet-2214	295	2	nlcs	nlcs	PROPN
admet-2214	295	3	had	have	VERB
admet-2214	295	4	the	the	DET
admet-2214	295	5	greatest	great	ADJ
admet-2214	295	6	therapeutic	therapeutic	ADJ
admet-2214	295	7	efficacy	efficacy	NOUN
admet-2214	295	8	because	because	SCONJ
admet-2214	295	9	to	to	ADP
admet-2214	295	10	their	their	PRON
admet-2214	295	11	improved	improve	VERB
admet-2214	295	12	in	in	ADP
admet-2214	295	13	vitro	vitro	X
admet-2214	295	14	cytotoxicity	cytotoxicity	NOUN
admet-2214	295	15	and	and	CCONJ
admet-2214	295	16	apoptosis	apoptosis	NOUN
admet-2214	295	17	,	,	PUNCT
admet-2214	295	18	longer	long	ADJ
admet-2214	295	19	survival	survival	NOUN
admet-2214	295	20	rate	rate	NOUN
admet-2214	295	21	,	,	PUNCT
admet-2214	295	22	and	and	CCONJ
admet-2214	295	23	excellent	excellent	ADJ
admet-2214	295	24	anti	anti	ADJ
admet-2214	295	25	-	-	ADJ
admet-2214	295	26	glioma	glioma	ADJ
admet-2214	295	27	behavior	behavior	NOUN
admet-2214	295	28	in	in	ADP
admet-2214	295	29	mice	mouse	NOUN
admet-2214	295	30	with	with	ADP
admet-2214	295	31	intracranial	intracranial	ADJ
admet-2214	295	32	gliomas	glioma	NOUN
admet-2214	295	33	.	.	PUNCT
admet-2214	296	1	overall	overall	ADV
admet-2214	296	2	,	,	PUNCT
admet-2214	296	3	the	the	DET
admet-2214	296	4	targeting	target	VERB
admet-2214	296	5	platform	platform	NOUN
admet-2214	296	6	created	create	VERB
admet-2214	296	7	for	for	ADP
admet-2214	296	8	this	this	DET
admet-2214	296	9	work	work	NOUN
admet-2214	296	10	can	can	AUX
admet-2214	296	11	deliver	deliver	VERB
admet-2214	296	12	btz	btz	PROPN
admet-2214	296	13	to	to	ADP
admet-2214	296	14	glioma	glioma	NOUN
admet-2214	296	15	cells	cell	NOUN
admet-2214	296	16	and	and	CCONJ
admet-2214	296	17	overcome	overcome	VERB
admet-2214	296	18	several	several	ADJ
admet-2214	296	19	difficulties	difficulty	NOUN
admet-2214	296	20	to	to	PART
admet-2214	296	21	treat	treat	VERB
admet-2214	296	22	advanced	advanced	ADJ
admet-2214	296	23	brain	brain	NOUN
admet-2214	296	24	cancer	cancer	NOUN
admet-2214	296	25	with	with	ADP
admet-2214	296	26	potential	potential	ADJ
admet-2214	296	27	therapeutic	therapeutic	ADJ
admet-2214	296	28	results	result	NOUN
admet-2214	296	29	.	.	PUNCT
admet-2214	297	1	sn38	sn38	PROPN
admet-2214	297	2	(	(	PUNCT
admet-2214	297	3	active	active	ADJ
admet-2214	297	4	metabolite	metabolite	NOUN
admet-2214	297	5	of	of	ADP
admet-2214	297	6	irinotecan)[95	irinotecan)[95	NOUN
admet-2214	297	7	]	]	PUNCT
admet-2214	297	8	nano	nano	NOUN
admet-2214	297	9	lipid	lipid	NOUN
admet-2214	297	10	carriers	carrier	NOUN
admet-2214	297	11	polyvinyl	polyvinyl	NOUN
admet-2214	297	12	alcohol	alcohol	NOUN
admet-2214	297	13	,	,	PUNCT
admet-2214	297	14	vitamin	vitamin	NOUN
admet-2214	297	15	e	e	NOUN
admet-2214	297	16	tpgs	tpgs	NOUN
admet-2214	297	17	,	,	PUNCT
admet-2214	297	18	mtt	mtt	NOUN
admet-2214	297	19	,	,	PUNCT
admet-2214	297	20	oleic	oleic	NOUN
admet-2214	297	21	acid	acid	NOUN
admet-2214	297	22	,	,	PUNCT
admet-2214	297	23	cetyl	cetyl	NOUN
admet-2214	297	24	palmitate	palmitate	NOUN
admet-2214	297	25	.	.	PUNCT
admet-2214	298	1	irinotecan	irinotecan	PROPN
admet-2214	298	2	's	's	PART
admet-2214	298	3	active	active	ADJ
admet-2214	298	4	metabolite	metabolite	NOUN
admet-2214	298	5	,	,	PUNCT
admet-2214	298	6	sn38	sn38	PROPN
admet-2214	298	7	,	,	PUNCT
admet-2214	298	8	is	be	AUX
admet-2214	298	9	1000fold	1000fold	NUM
admet-2214	298	10	more	more	ADV
admet-2214	298	11	hazardous	hazardous	ADJ
admet-2214	298	12	.	.	PUNCT
admet-2214	299	1	however	however	ADV
admet-2214	299	2	,	,	PUNCT
admet-2214	299	3	its	its	PRON
admet-2214	299	4	low	low	ADJ
admet-2214	299	5	solubility	solubility	NOUN
admet-2214	299	6	and	and	CCONJ
admet-2214	299	7	stability	stability	NOUN
admet-2214	299	8	limit	limit	VERB
admet-2214	299	9	its	its	PRON
admet-2214	299	10	application	application	NOUN
admet-2214	299	11	.	.	PUNCT
admet-2214	300	1	this	this	DET
admet-2214	300	2	study	study	NOUN
admet-2214	300	3	produced	produce	VERB
admet-2214	300	4	sn38	sn38	PROPN
admet-2214	300	5	-	-	PUNCT
admet-2214	300	6	loaded	load	VERB
admet-2214	300	7	nlcs	nlcs	NOUN
admet-2214	300	8	and	and	CCONJ
admet-2214	300	9	examined	examine	VERB
admet-2214	300	10	their	their	PRON
admet-2214	300	11	cytotoxicity	cytotoxicity	NOUN
admet-2214	300	12	on	on	ADP
admet-2214	300	13	glioma	glioma	NOUN
admet-2214	300	14	cells	cell	NOUN
admet-2214	300	15	to	to	PART
admet-2214	300	16	overcome	overcome	VERB
admet-2214	300	17	these	these	DET
admet-2214	300	18	factors	factor	NOUN
admet-2214	300	19	.	.	PUNCT
admet-2214	301	1	two	two	NUM
admet-2214	301	2	methods	method	NOUN
admet-2214	301	3	were	be	AUX
admet-2214	301	4	selected	select	VERB
admet-2214	301	5	.	.	PUNCT
admet-2214	302	1	probe	probe	NOUN
admet-2214	302	2	ultrasoniccation	ultrasoniccation	NOUN
admet-2214	302	3	hot	hot	ADJ
admet-2214	302	4	homogenization	homogenization	NOUN
admet-2214	302	5	method	method	NOUN
admet-2214	302	6	.	.	PUNCT
admet-2214	303	1	modified	modify	VERB
admet-2214	303	2	emulsification	emulsification	NOUN
admet-2214	303	3	solvent	solvent	NOUN
admet-2214	303	4	evaporation	evaporation	NOUN
admet-2214	303	5	technique	technique	NOUN
admet-2214	303	6	size	size	NOUN
admet-2214	303	7	and	and	CCONJ
admet-2214	303	8	morphology	morphology	NOUN
admet-2214	303	9	,	,	PUNCT
admet-2214	303	10	entrapment	entrapment	ADJ
admet-2214	303	11	efficiency	efficiency	NOUN
admet-2214	303	12	,	,	PUNCT
admet-2214	303	13	drug	drug	NOUN
admet-2214	303	14	loading	loading	NOUN
admet-2214	303	15	capacity	capacity	NOUN
admet-2214	303	16	,	,	PUNCT
admet-2214	303	17	in	in	ADP
admet-2214	303	18	vitro	vitro	X
admet-2214	303	19	drug	drug	NOUN
admet-2214	303	20	release	release	NOUN
admet-2214	303	21	,	,	PUNCT
admet-2214	303	22	in	in	ADP
admet-2214	303	23	vitro	vitro	X
admet-2214	303	24	cell	cell	NOUN
admet-2214	303	25	viability	viability	NOUN
admet-2214	303	26	assay	assay	VERB
admet-2214	303	27	,	,	PUNCT
admet-2214	303	28	in	in	ADP
admet-2214	303	29	vitro	vitro	X
admet-2214	303	30	cellular	cellular	ADJ
admet-2214	303	31	uptake	uptake	NOUN
admet-2214	303	32	,	,	PUNCT
admet-2214	303	33	evaluation	evaluation	NOUN
admet-2214	303	34	of	of	ADP
admet-2214	303	35	sn38	sn38	PROPN
admet-2214	303	36	extraction	extraction	NOUN
admet-2214	303	37	yield	yield	NOUN
admet-2214	303	38	from	from	ADP
admet-2214	303	39	the	the	DET
admet-2214	303	40	release	release	NOUN
admet-2214	303	41	samples	sample	NOUN
admet-2214	303	42	.	.	PUNCT
admet-2214	304	1	the	the	DET
admet-2214	304	2	average	average	ADJ
admet-2214	304	3	loading	loading	NOUN
admet-2214	304	4	efficiency	efficiency	NOUN
admet-2214	304	5	was	be	AUX
admet-2214	304	6	9.5	9.5	NUM
admet-2214	304	7	%	%	NOUN
admet-2214	304	8	and	and	CCONJ
admet-2214	304	9	entrapment	entrapment	ADJ
admet-2214	304	10	81	81	NUM
admet-2214	304	11	%	%	NOUN
admet-2214	304	12	.	.	PUNCT
admet-2214	305	1	the	the	DET
admet-2214	305	2	mtt	mtt	NOUN
admet-2214	305	3	test	test	NOUN
admet-2214	305	4	revealed	reveal	VERB
admet-2214	305	5	that	that	SCONJ
admet-2214	305	6	nlcs	nlcs	PROPN
admet-2214	305	7	had	have	VERB
admet-2214	305	8	significantly	significantly	ADV
admet-2214	305	9	higher	high	ADJ
admet-2214	305	10	cytotoxicity	cytotoxicity	NOUN
admet-2214	305	11	on	on	ADP
admet-2214	305	12	u87	u87	NOUN
admet-2214	305	13	mg	mg	PROPN
admet-2214	305	14	human	human	ADJ
admet-2214	305	15	glioma	glioma	NOUN
admet-2214	305	16	cells	cell	NOUN
admet-2214	305	17	than	than	ADP
admet-2214	305	18	the	the	DET
admet-2214	305	19	free	free	ADJ
admet-2214	305	20	drug	drug	NOUN
admet-2214	305	21	.	.	PUNCT
admet-2214	306	1	thus	thus	ADV
admet-2214	306	2	,	,	PUNCT
admet-2214	306	3	the	the	DET
admet-2214	306	4	study	study	NOUN
admet-2214	306	5	found	find	VERB
admet-2214	306	6	promising	promise	VERB
admet-2214	306	7	nlc	nlc	PROPN
admet-2214	306	8	therapy	therapy	NOUN
admet-2214	306	9	potential	potential	NOUN
admet-2214	306	10	for	for	ADP
admet-2214	306	11	glioma	glioma	NOUN
admet-2214	306	12	.	.	PUNCT
admet-2214	307	1	etoposide	etoposide	NOUN
admet-2214	307	2	[	[	X
admet-2214	307	3	96	96	NUM
admet-2214	307	4	]	]	PUNCT
admet-2214	307	5	nano	nano	NOUN
admet-2214	307	6	lipid	lipid	NOUN
admet-2214	307	7	carriers	carrier	NOUN
admet-2214	307	8	folate	folate	VERB
admet-2214	307	9	,	,	PUNCT
admet-2214	307	10	glyceryl	glyceryl	NOUN
admet-2214	307	11	monostearate	monostearate	NOUN
admet-2214	307	12	,	,	PUNCT
admet-2214	307	13	soybean	soybean	NOUN
admet-2214	307	14	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2214	307	15	,	,	PUNCT
admet-2214	307	16	oleic	oleic	NOUN
admet-2214	307	17	acid	acid	PROPN
admet-2214	307	18	,	,	PUNCT
admet-2214	307	19	mtt	mtt	NOUN
admet-2214	307	20	,	,	PUNCT
admet-2214	307	21	pegdspe	pegdspe	VERB
admet-2214	307	22	this	this	DET
admet-2214	307	23	study	study	NOUN
admet-2214	307	24	developed	develop	VERB
admet-2214	307	25	etoposide	etoposide	NOUN
admet-2214	307	26	-	-	PUNCT
admet-2214	307	27	loaded	load	VERB
admet-2214	307	28	nlcs	nlcs	NOUN
admet-2214	307	29	coated	coat	VERB
admet-2214	307	30	with	with	ADP
admet-2214	307	31	folate	folate	NOUN
admet-2214	307	32	for	for	ADP
admet-2214	307	33	targeted	target	VERB
admet-2214	307	34	delivery	delivery	NOUN
admet-2214	307	35	to	to	ADP
admet-2214	307	36	fa	fa	NOUN
admet-2214	307	37	receptor	receptor	NOUN
admet-2214	307	38	-	-	PUNCT
admet-2214	307	39	overexpressing	overexpresse	VERB
admet-2214	307	40	malignancies	malignancy	NOUN
admet-2214	307	41	.	.	PUNCT
admet-2214	308	1	solvent	solvent	ADJ
admet-2214	308	2	injection	injection	NOUN
admet-2214	308	3	tecnhique	tecnhique	NOUN
admet-2214	308	4	sem	sem	PROPN
admet-2214	308	5	,	,	PUNCT
admet-2214	308	6	tem	tem	PROPN
admet-2214	308	7	,	,	PUNCT
admet-2214	308	8	particle	particle	NOUN
admet-2214	308	9	size	size	NOUN
admet-2214	308	10	,	,	PUNCT
admet-2214	308	11	zeta	zeta	NOUN
admet-2214	308	12	potential	potential	NOUN
admet-2214	308	13	,	,	PUNCT
admet-2214	308	14	polydispersity	polydispersity	NOUN
admet-2214	308	15	index	index	NOUN
admet-2214	308	16	,	,	PUNCT
admet-2214	308	17	serum	serum	NOUN
admet-2214	308	18	stability	stability	NOUN
admet-2214	308	19	,	,	PUNCT
admet-2214	308	20	in	in	ADP
admet-2214	308	21	vitro	vitro	X
admet-2214	308	22	drug	drug	NOUN
admet-2214	308	23	release	release	NOUN
admet-2214	308	24	,	,	PUNCT
admet-2214	308	25	tissues	tissue	NOUN
admet-2214	308	26	distribution	distribution	NOUN
admet-2214	308	27	assay	assay	VERB
admet-2214	308	28	,	,	PUNCT
admet-2214	308	29	cell	cell	NOUN
admet-2214	308	30	viability	viability	NOUN
admet-2214	308	31	study	study	NOUN
admet-2214	308	32	,	,	PUNCT
admet-2214	308	33	anti	anti	ADJ
admet-2214	308	34	-	-	ADJ
admet-2214	308	35	tumor	tumor	ADJ
admet-2214	308	36	effects	effect	NOUN
admet-2214	308	37	in	in	ADP
admet-2214	308	38	vivo	vivo	NOUN
admet-2214	308	39	,	,	PUNCT
admet-2214	308	40	fa	fa	X
admet-2214	308	41	-	-	PUNCT
admet-2214	308	42	etp	etp	PROPN
admet-2214	308	43	-	-	PUNCT
admet-2214	308	44	nlcs	nlcs	PROPN
admet-2214	308	45	were	be	AUX
admet-2214	308	46	received	receive	VERB
admet-2214	308	47	by	by	ADP
admet-2214	308	48	ct26	ct26	PROPN
admet-2214	308	49	,	,	PUNCT
admet-2214	308	50	sgc790	sgc790	NOUN
admet-2214	308	51	,	,	PUNCT
admet-2214	308	52	and	and	CCONJ
admet-2214	308	53	nci	nci	PROPN
admet-2214	308	54	-	-	PUNCT
admet-2214	308	55	h209	h209	PROPN
admet-2214	308	56	cells	cell	NOUN
admet-2214	308	57	overexpressing	overexpresse	VERB
admet-2214	308	58	fa	fa	NOUN
admet-2214	308	59	receptors	receptor	NOUN
admet-2214	308	60	.	.	PUNCT
admet-2214	309	1	fa	fa	X
admet-2214	309	2	-	-	PUNCT
admet-2214	309	3	etp	etp	PROPN
admet-2214	309	4	-	-	PUNCT
admet-2214	309	5	nlcs	nlcs	PROPN
admet-2214	309	6	also	also	ADV
admet-2214	309	7	carry	carry	VERB
admet-2214	309	8	etp	etp	PROPN
admet-2214	309	9	to	to	ADP
admet-2214	309	10	cancer	cancer	NOUN
admet-2214	309	11	cells	cell	NOUN
admet-2214	309	12	,	,	PUNCT
admet-2214	309	13	enhancing	enhance	VERB
admet-2214	309	14	their	their	PRON
admet-2214	309	15	anticancer	anticancer	NOUN
admet-2214	309	16	potential	potential	NOUN
admet-2214	309	17	.	.	PUNCT
admet-2214	310	1	fa	fa	X
admet-2214	310	2	-	-	PUNCT
admet-2214	310	3	etp	etp	PROPN
admet-2214	310	4	-	-	PUNCT
admet-2214	310	5	nlcs	nlcs	PROPN
admet-2214	310	6	may	may	AUX
admet-2214	310	7	be	be	AUX
admet-2214	310	8	a	a	DET
admet-2214	310	9	better	well	ADJ
admet-2214	310	10	tumor	tumor	NOUN
admet-2214	310	11	nanomedicine	nanomedicine	NOUN
admet-2214	310	12	.	.	PUNCT
admet-2214	311	1	role	role	NOUN
admet-2214	311	2	of	of	ADP
admet-2214	311	3	hybrid	hybrid	ADJ
admet-2214	311	4	nano	nano	NOUN
admet-2214	311	5	lipid	lipid	NOUN
admet-2214	311	6	carriers	carrier	NOUN
admet-2214	311	7	in	in	ADP
admet-2214	311	8	dipg	dipg	NOUN
admet-2214	311	9	in	in	ADP
admet-2214	311	10	order	order	NOUN
admet-2214	311	11	to	to	PART
admet-2214	311	12	accomplish	accomplish	VERB
admet-2214	311	13	several	several	ADJ
admet-2214	311	14	roles	role	NOUN
admet-2214	311	15	and	and	CCONJ
admet-2214	311	16	to	to	PART
admet-2214	311	17	overcome	overcome	VERB
admet-2214	311	18	the	the	DET
admet-2214	311	19	drawbacks	drawback	NOUN
admet-2214	311	20	of	of	ADP
admet-2214	311	21	single	single	ADJ
admet-2214	311	22	-	-	PUNCT
admet-2214	311	23	component	component	NOUN
admet-2214	311	24	nanomaterials	nanomaterial	NOUN
admet-2214	311	25	,	,	PUNCT
admet-2214	311	26	hybrid	hybrid	ADJ
admet-2214	311	27	nanolipid	nanolipid	ADJ
admet-2214	311	28	carriers	carrier	NOUN
admet-2214	311	29	were	be	AUX
admet-2214	311	30	developed	develop	VERB
admet-2214	311	31	as	as	ADP
admet-2214	311	32	a	a	DET
admet-2214	311	33	mixed	mixed	ADJ
admet-2214	311	34	system	system	NOUN
admet-2214	311	35	made	make	VERB
admet-2214	311	36	up	up	ADP
admet-2214	311	37	of	of	ADP
admet-2214	311	38	a	a	DET
admet-2214	311	39	minimum	minimum	NOUN
admet-2214	311	40	of	of	ADP
admet-2214	311	41	two	two	NUM
admet-2214	311	42	different	different	ADJ
admet-2214	311	43	categories	category	NOUN
admet-2214	311	44	of	of	ADP
admet-2214	311	45	materials	material	NOUN
admet-2214	311	46	,	,	PUNCT
admet-2214	311	47	combining	combine	VERB
admet-2214	311	48	the	the	DET
admet-2214	311	49	benefits	benefit	NOUN
admet-2214	311	50	of	of	ADP
admet-2214	311	51	the	the	DET
admet-2214	311	52	two	two	NUM
admet-2214	311	53	separate	separate	ADJ
admet-2214	311	54	components	component	NOUN
admet-2214	311	55	[	[	X
admet-2214	311	56	97	97	NUM
admet-2214	311	57	]	]	PUNCT
admet-2214	311	58	.	.	PUNCT
admet-2214	312	1	hybrid	hybrid	PROPN
admet-2214	312	2	nlcs	nlcs	PROPN
admet-2214	312	3	usually	usually	ADV
admet-2214	312	4	consist	consist	VERB
admet-2214	312	5	of	of	ADP
admet-2214	312	6	a	a	DET
admet-2214	312	7	polymeric	polymeric	ADJ
admet-2214	312	8	core	core	NOUN
admet-2214	312	9	containing	contain	VERB
admet-2214	312	10	a	a	DET
admet-2214	312	11	therapeutic	therapeutic	ADJ
admet-2214	312	12	agent	agent	NOUN
admet-2214	312	13	enveloped	envelop	VERB
admet-2214	312	14	by	by	ADP
admet-2214	312	15	an	an	DET
admet-2214	312	16	inner	inner	ADJ
admet-2214	312	17	lipid	lipid	NOUN
admet-2214	312	18	layer	layer	NOUN
admet-2214	312	19	and	and	CCONJ
admet-2214	312	20	a	a	DET
admet-2214	312	21	pegylated	pegylated	ADJ
admet-2214	312	22	outer	outer	ADJ
admet-2214	312	23	layer	layer	NOUN
admet-2214	312	24	[	[	X
admet-2214	312	25	98	98	NUM
admet-2214	312	26	]	]	PUNCT
admet-2214	312	27	.	.	PUNCT
admet-2214	313	1	benefiting	benefit	VERB
admet-2214	313	2	the	the	DET
admet-2214	313	3	characteristics	characteristic	NOUN
admet-2214	313	4	of	of	ADP
admet-2214	313	5	both	both	CCONJ
admet-2214	313	6	lipids	lipid	NOUN
admet-2214	313	7	and	and	CCONJ
admet-2214	313	8	polymers	polymer	NOUN
admet-2214	313	9	,	,	PUNCT
admet-2214	313	10	hybrid	hybrid	ADJ
admet-2214	313	11	nlcs	nlcs	NOUN
admet-2214	313	12	were	be	AUX
admet-2214	313	13	made	make	VERB
admet-2214	313	14	with	with	ADP
admet-2214	313	15	greater	great	ADJ
admet-2214	313	16	stability	stability	NOUN
admet-2214	313	17	,	,	PUNCT
admet-2214	313	18	sustained	sustain	VERB
admet-2214	313	19	release	release	NOUN
admet-2214	313	20	and	and	CCONJ
admet-2214	313	21	high	high	ADJ
admet-2214	313	22	compatibility	compatibility	NOUN
admet-2214	313	23	[	[	X
admet-2214	313	24	98	98	NUM
admet-2214	313	25	-	-	SYM
admet-2214	313	26	100	100	NUM
admet-2214	313	27	]	]	PUNCT
admet-2214	313	28	.	.	PUNCT
admet-2214	314	1	table	table	NOUN
admet-2214	314	2	5	5	NUM
admet-2214	314	3	highlights	highlight	NOUN
admet-2214	314	4	the	the	DET
admet-2214	314	5	preclinical	preclinical	ADJ
admet-2214	314	6	studies	study	NOUN
admet-2214	314	7	done	do	VERB
admet-2214	314	8	on	on	ADP
admet-2214	314	9	hybrid	hybrid	ADJ
admet-2214	314	10	nano	nano	NOUN
admet-2214	314	11	lipid	lipid	NOUN
admet-2214	314	12	carriers	carrier	NOUN
admet-2214	314	13	conducted	conduct	VERB
admet-2214	314	14	in	in	ADP
admet-2214	314	15	dipg	dipg	PROPN
admet-2214	314	16	.	.	PUNCT
admet-2214	315	1	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	315	2	z.	z.	PROPN
admet-2214	315	3	presswala	presswala	PROPN
admet-2214	315	4	et	et	PROPN
admet-2214	315	5	al	al	PROPN
admet-2214	315	6	.	.	PROPN
admet-2214	315	7	admet	admet	PROPN
admet-2214	315	8	&	&	CCONJ
admet-2214	315	9	dmpk	dmpk	PROPN
admet-2214	315	10	12(3	12(3	PROPN
admet-2214	315	11	)	)	PUNCT
admet-2214	315	12	(	(	PUNCT
admet-2214	315	13	2024	2024	NUM
admet-2214	315	14	)	)	PUNCT
admet-2214	315	15	403	403	NUM
admet-2214	315	16	-	-	SYM
admet-2214	315	17	429	429	NUM
admet-2214	315	18	418	418	NUM
admet-2214	315	19	table	table	NOUN
admet-2214	315	20	5	5	NUM
admet-2214	315	21	.	.	PUNCT
admet-2214	316	1	preclinical	preclinical	ADJ
admet-2214	316	2	studies	study	NOUN
admet-2214	316	3	of	of	ADP
admet-2214	316	4	hybrid	hybrid	ADJ
admet-2214	316	5	nano	nano	NOUN
admet-2214	316	6	lipid	lipid	NOUN
admet-2214	316	7	carriers	carrier	NOUN
admet-2214	316	8	in	in	ADP
admet-2214	316	9	dipg	dipg	NOUN
admet-2214	316	10	drug	drug	NOUN
admet-2214	316	11	formulation	formulation	NOUN
admet-2214	316	12	excipients	excipient	NOUN
admet-2214	316	13	overview	overview	VERB
admet-2214	316	14	method	method	NOUN
admet-2214	316	15	of	of	ADP
admet-2214	316	16	preparation	preparation	NOUN
admet-2214	316	17	evaluation	evaluation	NOUN
admet-2214	316	18	parameters	parameter	NOUN
admet-2214	316	19	outcome	outcome	VERB
admet-2214	316	20	paclitaxel	paclitaxel	ADJ
admet-2214	316	21	[	[	X
admet-2214	316	22	101	101	NUM
admet-2214	316	23	]	]	PUNCT
admet-2214	316	24	hydrogel	hydrogel	NOUN
admet-2214	316	25	hybrid	hybrid	NOUN
admet-2214	316	26	system	system	NOUN
admet-2214	316	27	not	not	PART
admet-2214	316	28	disclosed	disclose	VERB
admet-2214	316	29	the	the	DET
admet-2214	316	30	aim	aim	NOUN
admet-2214	316	31	of	of	ADP
admet-2214	316	32	this	this	DET
admet-2214	316	33	study	study	NOUN
admet-2214	316	34	was	be	AUX
admet-2214	316	35	to	to	PART
admet-2214	316	36	design	design	VERB
admet-2214	316	37	in	in	ADP
admet-2214	316	38	situ	situ	ADJ
admet-2214	316	39	sustained	sustain	VERB
admet-2214	316	40	-	-	PUNCT
admet-2214	316	41	release	release	NOUN
admet-2214	316	42	hydrogel	hydrogel	NOUN
admet-2214	316	43	delivery	delivery	NOUN
admet-2214	316	44	device	device	NOUN
admet-2214	316	45	for	for	ADP
admet-2214	316	46	glioma	glioma	NOUN
admet-2214	316	47	that	that	PRON
admet-2214	316	48	combines	combine	VERB
admet-2214	316	49	immunoadjuvant	immunoadjuvant	ADJ
admet-2214	316	50	and	and	CCONJ
admet-2214	316	51	chemotherapeutic	chemotherapeutic	ADJ
admet-2214	316	52	medication	medication	NOUN
admet-2214	316	53	for	for	ADP
admet-2214	316	54	local	local	ADJ
admet-2214	316	55	distribution	distribution	NOUN
admet-2214	316	56	into	into	ADP
admet-2214	316	57	the	the	DET
admet-2214	316	58	resection	resection	NOUN
admet-2214	316	59	cavity	cavity	NOUN
admet-2214	316	60	.	.	PUNCT
admet-2214	317	1	a	a	DET
admet-2214	317	2	thermosensitive	thermosensitive	ADJ
admet-2214	317	3	hydrogel	hydrogel	NOUN
admet-2214	317	4	framework	framework	NOUN
admet-2214	317	5	(	(	PUNCT
admet-2214	317	6	plga1750	plga1750	NOUN
admet-2214	317	7	-	-	PUNCT
admet-2214	317	8	peg1500plga1750	peg1500plga1750	NOUN
admet-2214	317	9	)	)	PUNCT
admet-2214	317	10	was	be	AUX
admet-2214	317	11	used	use	VERB
admet-2214	317	12	to	to	PART
admet-2214	317	13	embed	embed	VERB
admet-2214	317	14	mannitolated	mannitolate	VERB
admet-2214	317	15	immunoadjuvant	immunoadjuvant	ADJ
admet-2214	317	16	cpg	cpg	NOUN
admet-2214	317	17	targeting	target	VERB
admet-2214	317	18	nanoparticles	nanoparticle	NOUN
admet-2214	317	19	(	(	PUNCT
admet-2214	317	20	mnpcpg	mnpcpg	NOUN
admet-2214	317	21	)	)	PUNCT
admet-2214	317	22	and	and	CCONJ
admet-2214	317	23	glioma	glioma	NOUN
admet-2214	317	24	homing	homing	NOUN
admet-2214	317	25	peptide	peptide	NOUN
admet-2214	317	26	modified	modify	VERB
admet-2214	317	27	paclitaxel	paclitaxel	NOUN
admet-2214	317	28	targeting	target	VERB
admet-2214	317	29	nanoparticles	nanoparticle	NOUN
admet-2214	317	30	(	(	PUNCT
admet-2214	317	31	pnpptx&mnpcpg@gel	pnpptx&mnpcpg@gel	PROPN
admet-2214	317	32	)	)	PUNCT
admet-2214	317	33	.	.	PUNCT
admet-2214	318	1	not	not	PART
admet-2214	318	2	disclosed	disclose	VERB
admet-2214	318	3	not	not	PART
admet-2214	318	4	disclosed	disclose	VERB
admet-2214	318	5	the	the	DET
admet-2214	318	6	study	study	NOUN
admet-2214	318	7	findings	finding	NOUN
admet-2214	318	8	indicate	indicate	VERB
admet-2214	318	9	that	that	SCONJ
admet-2214	318	10	the	the	DET
admet-2214	318	11	utilization	utilization	NOUN
admet-2214	318	12	of	of	ADP
admet-2214	318	13	a	a	DET
admet-2214	318	14	targeting	target	VERB
admet-2214	318	15	nanoparticles	nanoparticle	NOUN
admet-2214	318	16	-	-	PUNCT
admet-2214	318	17	hydrogel	hydrogel	NOUN
admet-2214	318	18	hybrid	hybrid	NOUN
admet-2214	318	19	system	system	NOUN
admet-2214	318	20	has	have	AUX
admet-2214	318	21	demonstrated	demonstrate	VERB
admet-2214	318	22	the	the	DET
admet-2214	318	23	ability	ability	NOUN
admet-2214	318	24	to	to	PART
admet-2214	318	25	form	form	VERB
admet-2214	318	26	a	a	DET
admet-2214	318	27	gel	gel	NOUN
admet-2214	318	28	drug	drug	NOUN
admet-2214	318	29	reservoir	reservoir	NOUN
admet-2214	318	30	upon	upon	SCONJ
admet-2214	318	31	injection	injection	NOUN
admet-2214	318	32	into	into	ADP
admet-2214	318	33	the	the	DET
admet-2214	318	34	glioma	glioma	NOUN
admet-2214	318	35	resection	resection	NOUN
admet-2214	318	36	cavity	cavity	NOUN
admet-2214	318	37	.	.	PUNCT
admet-2214	319	1	this	this	DET
admet-2214	319	2	conclusion	conclusion	NOUN
admet-2214	319	3	is	be	AUX
admet-2214	319	4	supported	support	VERB
admet-2214	319	5	by	by	ADP
admet-2214	319	6	in	in	ADP
admet-2214	319	7	vitro	vitro	X
admet-2214	319	8	as	as	ADV
admet-2214	319	9	well	well	ADV
admet-2214	319	10	as	as	ADP
admet-2214	319	11	in	in	ADP
admet-2214	319	12	vivo	vivo	NOUN
admet-2214	319	13	results	result	NOUN
admet-2214	319	14	.	.	PUNCT
admet-2214	320	1	the	the	DET
admet-2214	320	2	potential	potential	ADJ
admet-2214	320	3	targeting	targeting	NOUN
admet-2214	320	4	of	of	ADP
admet-2214	320	5	residual	residual	ADJ
admet-2214	320	6	infiltration	infiltration	NOUN
admet-2214	320	7	glioma	glioma	NOUN
admet-2214	320	8	cells	cell	NOUN
admet-2214	320	9	by	by	ADP
admet-2214	320	10	the	the	DET
admet-2214	320	11	sustained	sustain	VERB
admet-2214	320	12	-	-	PUNCT
admet-2214	320	13	release	release	NOUN
admet-2214	320	14	pnpptx	pnpptx	NOUN
admet-2214	320	15	,	,	PUNCT
admet-2214	320	16	leading	lead	VERB
admet-2214	320	17	to	to	ADP
admet-2214	320	18	the	the	DET
admet-2214	320	19	production	production	NOUN
admet-2214	320	20	of	of	ADP
admet-2214	320	21	tumor	tumor	NOUN
admet-2214	320	22	antigens	antigen	NOUN
admet-2214	320	23	,	,	PUNCT
admet-2214	320	24	is	be	AUX
admet-2214	320	25	an	an	DET
admet-2214	320	26	intriguing	intriguing	ADJ
admet-2214	320	27	avenue	avenue	NOUN
admet-2214	320	28	of	of	ADP
admet-2214	320	29	investigation	investigation	NOUN
admet-2214	320	30	.	.	PUNCT
admet-2214	321	1	therefore	therefore	ADV
admet-2214	321	2	,	,	PUNCT
admet-2214	321	3	this	this	DET
admet-2214	321	4	gel	gel	NOUN
admet-2214	321	5	has	have	VERB
admet-2214	321	6	the	the	DET
admet-2214	321	7	potential	potential	NOUN
admet-2214	321	8	to	to	PART
admet-2214	321	9	augment	augment	VERB
admet-2214	321	10	the	the	DET
admet-2214	321	11	therapeutic	therapeutic	ADJ
admet-2214	321	12	efficacy	efficacy	NOUN
admet-2214	321	13	for	for	ADP
admet-2214	321	14	glioma	glioma	NOUN
admet-2214	321	15	.	.	PUNCT
admet-2214	322	1	docetaxel	docetaxel	PROPN
admet-2214	323	1	[	[	X
admet-2214	323	2	102	102	NUM
admet-2214	323	3	]	]	PUNCT
admet-2214	323	4	lipid	lipid	ADJ
admet-2214	323	5	polymer	polymer	NOUN
admet-2214	323	6	hybrid	hybrid	ADJ
admet-2214	323	7	nanoparticles	nanoparticle	NOUN
admet-2214	323	8	plga	plga	VERB
admet-2214	323	9	,	,	PUNCT
admet-2214	323	10	soybean	soybean	NOUN
admet-2214	323	11	lecithin	lecithin	NOUN
admet-2214	323	12	,	,	PUNCT
admet-2214	323	13	caumarin6	caumarin6	PROPN
admet-2214	323	14	,	,	PUNCT
admet-2214	323	15	arginine	arginine	NOUN
admet-2214	323	16	-	-	PUNCT
admet-2214	323	17	glycine	glycine	NOUN
admet-2214	323	18	-	-	PUNCT
admet-2214	323	19	aspartic	aspartic	ADJ
admet-2214	323	20	(	(	PUNCT
admet-2214	323	21	rgd	rgd	PROPN
admet-2214	323	22	)	)	PUNCT
admet-2214	323	23	the	the	DET
admet-2214	323	24	primary	primary	ADJ
admet-2214	323	25	aim	aim	NOUN
admet-2214	323	26	of	of	ADP
admet-2214	323	27	this	this	DET
admet-2214	323	28	study	study	NOUN
admet-2214	323	29	was	be	AUX
admet-2214	323	30	to	to	PART
admet-2214	323	31	develop	develop	VERB
admet-2214	323	32	a	a	DET
admet-2214	323	33	targeted	target	VERB
admet-2214	323	34	delivery	delivery	NOUN
admet-2214	323	35	system	system	NOUN
admet-2214	323	36	for	for	ADP
admet-2214	323	37	the	the	DET
admet-2214	323	38	anticancer	anticancer	NOUN
admet-2214	323	39	drug	drug	NOUN
admet-2214	323	40	docetaxel	docetaxel	NOUN
admet-2214	323	41	.	.	PUNCT
admet-2214	324	1	to	to	PART
admet-2214	324	2	achieve	achieve	VERB
admet-2214	324	3	this	this	PRON
admet-2214	324	4	,	,	PUNCT
admet-2214	324	5	a	a	DET
admet-2214	324	6	novel	novel	ADJ
admet-2214	324	7	approach	approach	NOUN
admet-2214	324	8	involving	involve	VERB
admet-2214	324	9	the	the	DET
admet-2214	324	10	synthesis	synthesis	NOUN
admet-2214	324	11	of	of	ADP
admet-2214	324	12	hybrid	hybrid	ADJ
admet-2214	324	13	nanoparticles	nanoparticle	NOUN
admet-2214	324	14	composed	compose	VERB
admet-2214	324	15	of	of	ADP
admet-2214	324	16	lipids	lipid	NOUN
admet-2214	324	17	and	and	CCONJ
admet-2214	324	18	the	the	DET
admet-2214	324	19	biodegradable	biodegradable	ADJ
admet-2214	324	20	polymer	polymer	NOUN
admet-2214	324	21	poly	poly	NOUN
admet-2214	324	22	(	(	PUNCT
admet-2214	324	23	d	d	NOUN
admet-2214	324	24	,	,	PUNCT
admet-2214	324	25	l	l	ADJ
admet-2214	324	26	-	-	ADJ
admet-2214	324	27	lactide	lactide	ADV
admet-2214	324	28	-	-	PUNCT
admet-2214	324	29	coglycolide	coglycolide	NOUN
admet-2214	324	30	)	)	PUNCT
admet-2214	324	31	(	(	PUNCT
admet-2214	324	32	plga	plga	NOUN
admet-2214	324	33	)	)	PUNCT
admet-2214	324	34	was	be	AUX
admet-2214	324	35	employed	employ	VERB
admet-2214	324	36	.	.	PUNCT
admet-2214	325	1	solvent	solvent	ADJ
admet-2214	325	2	extraction	extraction	NOUN
admet-2214	325	3	evaporation	evaporation	NOUN
admet-2214	325	4	method	method	NOUN
admet-2214	325	5	size	size	NOUN
admet-2214	325	6	,	,	PUNCT
admet-2214	325	7	zeta	zeta	NOUN
admet-2214	325	8	potential	potential	NOUN
admet-2214	325	9	,	,	PUNCT
admet-2214	325	10	encapsulation	encapsulation	NOUN
admet-2214	325	11	efficiency	efficiency	NOUN
admet-2214	325	12	,	,	PUNCT
admet-2214	325	13	in	in	ADP
admet-2214	325	14	vitro	vitro	X
admet-2214	325	15	drug	drug	NOUN
admet-2214	325	16	release	release	NOUN
admet-2214	325	17	,	,	PUNCT
admet-2214	325	18	in	in	ADP
admet-2214	325	19	vitro	vitro	X
admet-2214	325	20	cellular	cellular	ADJ
admet-2214	325	21	uptake	uptake	NOUN
admet-2214	325	22	,	,	PUNCT
admet-2214	325	23	tumor	tumor	NOUN
admet-2214	325	24	spheroid	spheroid	NOUN
admet-2214	325	25	penetration	penetration	NOUN
admet-2214	325	26	,	,	PUNCT
admet-2214	325	27	growth	growth	NOUN
admet-2214	325	28	inhibition	inhibition	NOUN
admet-2214	325	29	of	of	ADP
admet-2214	325	30	tumor	tumor	NOUN
admet-2214	325	31	spheroid	spheroid	NOUN
admet-2214	325	32	,	,	PUNCT
admet-2214	325	33	cytotoxicity	cytotoxicity	NOUN
admet-2214	325	34	of	of	ADP
admet-2214	325	35	docetaxel	docetaxel	NOUN
admet-2214	325	36	,	,	PUNCT
admet-2214	325	37	in	in	ADP
admet-2214	325	38	vivo	vivo	ADJ
admet-2214	325	39	anti	anti	ADJ
admet-2214	325	40	gbm	gbm	PROPN
admet-2214	325	41	effects	effect	NOUN
admet-2214	325	42	,	,	PUNCT
admet-2214	325	43	in	in	ADP
admet-2214	325	44	vivo	vivo	ADJ
admet-2214	325	45	imaging	imaging	NOUN
admet-2214	325	46	upon	upon	SCONJ
admet-2214	325	47	administration	administration	NOUN
admet-2214	325	48	of	of	ADP
admet-2214	325	49	docetaxel	docetaxel	NOUN
admet-2214	325	50	-	-	PUNCT
admet-2214	325	51	loaded	load	VERB
admet-2214	325	52	arginineglycineaspartic	arginineglycineaspartic	ADJ
admet-2214	325	53	acid	acid	NOUN
admet-2214	325	54	lipid	lipid	NOUN
admet-2214	325	55	nanoparticles	nanoparticle	NOUN
admet-2214	325	56	(	(	PUNCT
admet-2214	325	57	rgd	rgd	NOUN
admet-2214	325	58	-	-	PUNCT
admet-2214	325	59	l	l	NOUN
admet-2214	325	60	-	-	NOUN
admet-2214	325	61	p	p	X
admet-2214	325	62	)	)	PUNCT
admet-2214	325	63	,	,	PUNCT
admet-2214	325	64	a	a	DET
admet-2214	325	65	noteworthy	noteworthy	ADJ
admet-2214	325	66	observation	observation	NOUN
admet-2214	325	67	was	be	AUX
admet-2214	325	68	made	make	VERB
admet-2214	325	69	regarding	regard	VERB
admet-2214	325	70	the	the	DET
admet-2214	325	71	median	median	ADJ
admet-2214	325	72	survival	survival	NOUN
admet-2214	325	73	time	time	NOUN
admet-2214	325	74	of	of	ADP
admet-2214	325	75	rats	rat	NOUN
admet-2214	325	76	afflicted	afflict	VERB
admet-2214	325	77	with	with	ADP
admet-2214	325	78	glioblastoma	glioblastoma	NOUN
admet-2214	325	79	multiforme	multiforme	NOUN
admet-2214	325	80	(	(	PUNCT
admet-2214	325	81	gbm	gbm	NOUN
admet-2214	325	82	)	)	PUNCT
admet-2214	325	83	.	.	PUNCT
admet-2214	326	1	the	the	DET
admet-2214	326	2	recorded	record	VERB
admet-2214	326	3	median	median	PROPN
admet-2214	326	4	survival	survival	NOUN
admet-2214	326	5	time	time	NOUN
admet-2214	326	6	was	be	AUX
admet-2214	326	7	documented	document	VERB
admet-2214	326	8	to	to	PART
admet-2214	326	9	be	be	AUX
admet-2214	326	10	57	57	NUM
admet-2214	326	11	days	day	NOUN
admet-2214	326	12	.	.	PUNCT
admet-2214	327	1	the	the	DET
admet-2214	327	2	results	result	NOUN
admet-2214	327	3	demonstrate	demonstrate	VERB
admet-2214	327	4	a	a	DET
admet-2214	327	5	notable	notable	ADJ
admet-2214	327	6	fold	fold	ADJ
admet-2214	327	7	increase	increase	NOUN
admet-2214	327	8	of	of	ADP
admet-2214	327	9	1.43	1.43	NUM
admet-2214	327	10	,	,	PUNCT
admet-2214	327	11	1.78	1.78	NUM
admet-2214	327	12	,	,	PUNCT
admet-2214	327	13	3.35	3.35	NUM
admet-2214	327	14	,	,	PUNCT
admet-2214	327	15	and	and	CCONJ
admet-2214	327	16	3.56	3.56	NUM
admet-2214	327	17	in	in	ADP
admet-2214	327	18	comparison	comparison	NOUN
admet-2214	327	19	to	to	ADP
admet-2214	327	20	rats	rat	NOUN
admet-2214	327	21	treated	treat	VERB
admet-2214	327	22	with	with	ADP
admet-2214	327	23	l	l	NOUN
admet-2214	327	24	-	-	NOUN
admet-2214	327	25	p	p	X
admet-2214	327	26	(	(	PUNCT
admet-2214	327	27	p	p	X
admet-2214	327	28	<	<	X
admet-2214	327	29	0.05	0.05	NUM
admet-2214	327	30	)	)	PUNCT
admet-2214	327	31	,	,	PUNCT
admet-2214	327	32	plgap	plgap	NOUN
admet-2214	327	33	(	(	PUNCT
admet-2214	327	34	p	p	X
admet-2214	327	35	<	<	X
admet-2214	327	36	0.05	0.05	NUM
admet-2214	327	37	)	)	PUNCT
admet-2214	327	38	,	,	PUNCT
admet-2214	327	39	taxotere	taxotere	X
admet-2214	327	40	(	(	PUNCT
admet-2214	327	41	p	p	X
admet-2214	327	42	<	<	X
admet-2214	327	43	0.01	0.01	NUM
admet-2214	327	44	)	)	PUNCT
admet-2214	327	45	,	,	PUNCT
admet-2214	327	46	and	and	CCONJ
admet-2214	327	47	saline	saline	NOUN
admet-2214	327	48	(	(	PUNCT
admet-2214	327	49	p	p	X
admet-2214	327	50	<	<	X
admet-2214	327	51	0.01	0.01	NUM
admet-2214	327	52	)	)	PUNCT
admet-2214	327	53	,	,	PUNCT
admet-2214	327	54	respectively	respectively	ADV
admet-2214	327	55	.	.	PUNCT
admet-2214	328	1	apart	apart	ADV
admet-2214	328	2	from	from	ADP
admet-2214	328	3	brain	brain	NOUN
admet-2214	328	4	delivery	delivery	NOUN
admet-2214	328	5	,	,	PUNCT
admet-2214	328	6	lipid	lipid	NOUN
admet-2214	328	7	-	-	PUNCT
admet-2214	328	8	based	base	VERB
admet-2214	328	9	nanoparticles	nanoparticle	NOUN
admet-2214	328	10	are	be	AUX
admet-2214	328	11	widely	widely	ADV
admet-2214	328	12	used	use	VERB
admet-2214	328	13	in	in	ADP
admet-2214	328	14	oral	oral	ADJ
admet-2214	328	15	delivery	delivery	NOUN
admet-2214	328	16	,	,	PUNCT
admet-2214	328	17	pulmonary	pulmonary	ADJ
admet-2214	328	18	delivery	delivery	NOUN
admet-2214	328	19	,	,	PUNCT
admet-2214	328	20	topical	topical	ADJ
admet-2214	328	21	delivery	delivery	NOUN
admet-2214	328	22	,	,	PUNCT
admet-2214	328	23	and	and	CCONJ
admet-2214	328	24	ocular	ocular	ADJ
admet-2214	328	25	delivery	delivery	NOUN
admet-2214	328	26	.	.	PUNCT
admet-2214	329	1	toxicity	toxicity	NOUN
admet-2214	329	2	of	of	ADP
admet-2214	329	3	lipid	lipid	NOUN
admet-2214	329	4	-	-	PUNCT
admet-2214	329	5	based	base	VERB
admet-2214	329	6	nanoparticles	nanoparticle	NOUN
admet-2214	329	7	lipid	lipid	NOUN
admet-2214	329	8	-	-	PUNCT
admet-2214	329	9	based	base	VERB
admet-2214	329	10	nanoparticles	nanoparticle	NOUN
admet-2214	329	11	have	have	VERB
admet-2214	329	12	several	several	ADJ
admet-2214	329	13	benefits	benefit	NOUN
admet-2214	329	14	compared	compare	VERB
admet-2214	329	15	to	to	ADP
admet-2214	329	16	other	other	ADJ
admet-2214	329	17	types	type	NOUN
admet-2214	329	18	of	of	ADP
admet-2214	329	19	nanoparticles	nanoparticle	NOUN
admet-2214	329	20	.	.	PUNCT
admet-2214	330	1	lipid	lipid	NOUN
admet-2214	330	2	nanocarriers	nanocarrier	NOUN
admet-2214	330	3	such	such	ADJ
admet-2214	330	4	as	as	ADP
admet-2214	330	5	liposomes	liposome	NOUN
admet-2214	330	6	,	,	PUNCT
admet-2214	330	7	slns	slns	NOUN
admet-2214	330	8	,	,	PUNCT
admet-2214	330	9	and	and	CCONJ
admet-2214	330	10	nlcs	nlcs	PROPN
admet-2214	330	11	are	be	AUX
admet-2214	330	12	ideal	ideal	ADJ
admet-2214	330	13	for	for	ADP
admet-2214	330	14	incorporating	incorporate	VERB
admet-2214	330	15	both	both	CCONJ
admet-2214	330	16	hydrophilic	hydrophilic	ADJ
admet-2214	330	17	and	and	CCONJ
admet-2214	330	18	lipophilic	lipophilic	ADJ
admet-2214	330	19	drugs	drug	NOUN
admet-2214	330	20	,	,	PUNCT
admet-2214	330	21	one	one	NUM
admet-2214	330	22	of	of	ADP
admet-2214	330	23	the	the	DET
admet-2214	330	24	major	major	ADJ
admet-2214	330	25	advantages	advantage	NOUN
admet-2214	330	26	of	of	ADP
admet-2214	330	27	a	a	DET
admet-2214	330	28	combination	combination	NOUN
admet-2214	330	29	of	of	ADP
admet-2214	330	30	drugs	drug	NOUN
admet-2214	330	31	that	that	PRON
admet-2214	330	32	give	give	VERB
admet-2214	330	33	dual	dual	ADJ
admet-2214	330	34	targeting	targeting	NOUN
admet-2214	330	35	.	.	PUNCT
admet-2214	331	1	they	they	PRON
admet-2214	331	2	also	also	ADV
admet-2214	331	3	have	have	VERB
admet-2214	331	4	other	other	ADJ
admet-2214	331	5	advantages	advantage	NOUN
admet-2214	331	6	in	in	ADP
admet-2214	331	7	terms	term	NOUN
admet-2214	331	8	of	of	ADP
admet-2214	331	9	biocompatibility	biocompatibility	NOUN
admet-2214	331	10	,	,	PUNCT
admet-2214	331	11	shielding	shielding	NOUN
admet-2214	331	12	bioactive	bioactive	VERB
admet-2214	331	13	compounds	compound	NOUN
admet-2214	331	14	from	from	ADP
admet-2214	331	15	chemical	chemical	ADJ
admet-2214	331	16	deterioration	deterioration	NOUN
admet-2214	331	17	,	,	PUNCT
admet-2214	331	18	sitespecific	sitespecific	PROPN
admet-2214	331	19	controlled	control	VERB
admet-2214	331	20	drug	drug	NOUN
admet-2214	331	21	delivery	delivery	NOUN
admet-2214	331	22	,	,	PUNCT
admet-2214	331	23	and	and	CCONJ
admet-2214	331	24	high	high	ADJ
admet-2214	331	25	drug	drug	NOUN
admet-2214	331	26	loading	loading	NOUN
admet-2214	331	27	capacity	capacity	NOUN
admet-2214	331	28	,	,	PUNCT
admet-2214	331	29	these	these	DET
admet-2214	331	30	nanocarriers	nanocarrier	NOUN
admet-2214	331	31	are	be	AUX
admet-2214	331	32	superior	superior	ADJ
admet-2214	331	33	to	to	ADP
admet-2214	331	34	the	the	DET
admet-2214	331	35	others	other	NOUN
admet-2214	331	36	in	in	ADP
admet-2214	331	37	many	many	ADJ
admet-2214	331	38	ways	way	NOUN
admet-2214	331	39	.	.	PUNCT
admet-2214	332	1	stability	stability	NOUN
admet-2214	332	2	during	during	ADP
admet-2214	332	3	sterilization	sterilization	NOUN
admet-2214	332	4	and	and	CCONJ
admet-2214	332	5	ease	ease	NOUN
admet-2214	332	6	of	of	ADP
admet-2214	332	7	scaling	scale	VERB
admet-2214	332	8	up	up	ADP
admet-2214	332	9	are	be	AUX
admet-2214	332	10	two	two	NUM
admet-2214	332	11	more	more	ADJ
admet-2214	332	12	benefits	benefit	NOUN
admet-2214	332	13	.	.	PUNCT
admet-2214	333	1	at	at	ADP
admet-2214	333	2	last	last	ADV
admet-2214	333	3	,	,	PUNCT
admet-2214	333	4	there	there	PRON
admet-2214	333	5	is	be	VERB
admet-2214	333	6	no	no	DET
admet-2214	333	7	reported	reported	ADJ
admet-2214	333	8	toxicity	toxicity	NOUN
admet-2214	333	9	for	for	ADP
admet-2214	333	10	slns	slns	NOUN
admet-2214	333	11	and	and	CCONJ
admet-2214	333	12	nlcs	nlcs	NOUN
admet-2214	333	13	up	up	ADP
admet-2214	333	14	to	to	ADP
admet-2214	333	15	date	date	NOUN
admet-2214	333	16	.	.	PUNCT
admet-2214	334	1	physiological	physiological	ADJ
admet-2214	334	2	lipids	lipid	NOUN
admet-2214	334	3	,	,	PUNCT
admet-2214	334	4	generally	generally	ADV
admet-2214	334	5	accepted	accept	VERB
admet-2214	334	6	as	as	ADP
admet-2214	334	7	safe	safe	ADJ
admet-2214	334	8	(	(	PUNCT
admet-2214	334	9	gras	gra	NOUN
admet-2214	334	10	)	)	PUNCT
admet-2214	334	11	excipients	excipient	NOUN
admet-2214	334	12	,	,	PUNCT
admet-2214	334	13	make	make	VERB
admet-2214	334	14	up	up	ADP
admet-2214	334	15	the	the	DET
admet-2214	334	16	majority	majority	NOUN
admet-2214	334	17	of	of	ADP
admet-2214	334	18	these	these	DET
admet-2214	334	19	nanocarriers	nanocarrier	NOUN
admet-2214	334	20	[	[	X
admet-2214	334	21	75	75	NUM
admet-2214	334	22	]	]	PUNCT
admet-2214	334	23	.	.	PUNCT
admet-2214	335	1	before	before	ADP
admet-2214	335	2	getting	get	VERB
admet-2214	335	3	marketing	marketing	NOUN
admet-2214	335	4	authorization	authorization	NOUN
admet-2214	335	5	for	for	ADP
admet-2214	335	6	these	these	DET
admet-2214	335	7	nanocarriers	nanocarrier	NOUN
admet-2214	335	8	,	,	PUNCT
admet-2214	335	9	their	their	PRON
admet-2214	335	10	toxicity	toxicity	NOUN
admet-2214	335	11	profile	profile	NOUN
admet-2214	335	12	must	must	AUX
admet-2214	335	13	be	be	AUX
admet-2214	335	14	studied	study	VERB
admet-2214	335	15	[	[	PUNCT
admet-2214	335	16	103	103	NUM
admet-2214	335	17	]	]	PUNCT
admet-2214	335	18	.	.	PUNCT
admet-2214	336	1	further	far	ADV
admet-2214	336	2	,	,	PUNCT
admet-2214	336	3	we	we	PRON
admet-2214	336	4	discuss	discuss	VERB
admet-2214	336	5	the	the	DET
admet-2214	336	6	role	role	NOUN
admet-2214	336	7	of	of	ADP
admet-2214	336	8	lipid	lipid	NOUN
admet-2214	336	9	-	-	PUNCT
admet-2214	336	10	based	base	VERB
admet-2214	336	11	nanoparticles	nanoparticle	NOUN
admet-2214	336	12	in	in	ADP
admet-2214	336	13	cytotoxicity	cytotoxicity	NOUN
admet-2214	336	14	,	,	PUNCT
admet-2214	336	15	genotoxicity	genotoxicity	NOUN
admet-2214	336	16	and	and	CCONJ
admet-2214	336	17	hepatotoxicity	hepatotoxicity	NOUN
admet-2214	336	18	.	.	PUNCT
admet-2214	337	1	cytotoxicity	cytotoxicity	NOUN
admet-2214	337	2	the	the	DET
admet-2214	337	3	biocompatibility	biocompatibility	NOUN
admet-2214	337	4	of	of	ADP
admet-2214	337	5	all	all	DET
admet-2214	337	6	lipid	lipid	NOUN
admet-2214	337	7	-	-	PUNCT
admet-2214	337	8	based	base	VERB
admet-2214	337	9	nanoparticles	nanoparticle	NOUN
admet-2214	337	10	is	be	AUX
admet-2214	337	11	tested	test	VERB
admet-2214	337	12	by	by	ADP
admet-2214	337	13	determining	determine	VERB
admet-2214	337	14	their	their	PRON
admet-2214	337	15	cell	cell	NOUN
admet-2214	337	16	viability	viability	NOUN
admet-2214	337	17	or	or	CCONJ
admet-2214	337	18	cytotoxicity	cytotoxicity	NOUN
admet-2214	337	19	.	.	PUNCT
admet-2214	338	1	a	a	DET
admet-2214	338	2	cytotoxicity	cytotoxicity	NOUN
admet-2214	338	3	assay	assay	NOUN
admet-2214	338	4	is	be	AUX
admet-2214	338	5	conducted	conduct	VERB
admet-2214	338	6	to	to	PART
admet-2214	338	7	determine	determine	VERB
admet-2214	338	8	the	the	DET
admet-2214	338	9	potency	potency	NOUN
admet-2214	338	10	of	of	ADP
admet-2214	338	11	the	the	DET
admet-2214	338	12	anticancer	anticancer	NOUN
admet-2214	338	13	molecule	molecule	NOUN
admet-2214	338	14	.	.	PUNCT
admet-2214	339	1	cell	cell	NOUN
admet-2214	339	2	viability	viability	NOUN
admet-2214	339	3	is	be	AUX
admet-2214	339	4	tested	test	VERB
admet-2214	339	5	as	as	ADP
admet-2214	339	6	evidence	evidence	NOUN
admet-2214	339	7	in	in	ADP
admet-2214	339	8	cytotoxicity	cytotoxicity	NOUN
admet-2214	339	9	assay	assay	VERB
admet-2214	340	1	[	[	X
admet-2214	340	2	75	75	NUM
admet-2214	340	3	]	]	PUNCT
admet-2214	340	4	.	.	PUNCT
admet-2214	341	1	in	in	ADP
admet-2214	341	2	lipid	lipid	NOUN
admet-2214	341	3	-	-	PUNCT
admet-2214	341	4	based	base	VERB
admet-2214	341	5	nanoparticles	nanoparticle	NOUN
admet-2214	341	6	,	,	PUNCT
admet-2214	341	7	different	different	ADJ
admet-2214	341	8	cell	cell	NOUN
admet-2214	341	9	lines	line	NOUN
admet-2214	341	10	tolerate	tolerate	VERB
admet-2214	341	11	the	the	DET
admet-2214	341	12	lipids	lipid	NOUN
admet-2214	341	13	used	use	VERB
admet-2214	341	14	at	at	ADP
admet-2214	341	15	high	high	ADJ
admet-2214	341	16	dose	dose	NOUN
admet-2214	341	17	levels	level	NOUN
admet-2214	341	18	[	[	X
admet-2214	341	19	104	104	NUM
admet-2214	341	20	]	]	PUNCT
admet-2214	341	21	.	.	PUNCT
admet-2214	342	1	it	it	PRON
admet-2214	342	2	is	be	AUX
admet-2214	342	3	reported	report	VERB
admet-2214	342	4	that	that	SCONJ
admet-2214	342	5	most	most	ADJ
admet-2214	342	6	of	of	ADP
admet-2214	342	7	the	the	DET
admet-2214	342	8	cell	cell	NOUN
admet-2214	342	9	lines	line	NOUN
admet-2214	342	10	tolerate	tolerate	VERB
admet-2214	342	11	1	1	NUM
admet-2214	342	12	mg	mg	NUM
admet-2214	342	13	/	/	SYM
admet-2214	342	14	ml	ml	NOUN
admet-2214	342	15	lipid	lipid	PROPN
admet-2214	342	16	slns	slns	PROPN
admet-2214	342	17	/	/	SYM
admet-2214	342	18	lncs	lncs	PROPN
admet-2214	342	19	[	[	X
admet-2214	342	20	105	105	NUM
admet-2214	342	21	]	]	PUNCT
admet-2214	342	22	.	.	PUNCT
admet-2214	343	1	additionally	additionally	ADV
admet-2214	343	2	,	,	PUNCT
admet-2214	343	3	surfactants	surfactant	NOUN
admet-2214	343	4	are	be	AUX
admet-2214	343	5	crucial	crucial	ADJ
admet-2214	343	6	to	to	ADP
admet-2214	343	7	the	the	DET
admet-2214	343	8	stabilization	stabilization	NOUN
admet-2214	343	9	of	of	ADP
admet-2214	343	10	slns	slns	NOUN
admet-2214	343	11	.	.	PUNCT
admet-2214	344	1	cell	cell	NOUN
admet-2214	344	2	viability	viability	NOUN
admet-2214	344	3	is	be	AUX
admet-2214	344	4	admet	admet	PROPN
admet-2214	344	5	&	&	CCONJ
admet-2214	344	6	dmpk	dmpk	PROPN
admet-2214	344	7	12(3	12(3	PROPN
admet-2214	344	8	)	)	PUNCT
admet-2214	344	9	(	(	PUNCT
admet-2214	344	10	2024	2024	NUM
admet-2214	344	11	)	)	PUNCT
admet-2214	344	12	403	403	NUM
admet-2214	344	13	-	-	SYM
admet-2214	344	14	429	429	NUM
admet-2214	344	15	addressing	address	VERB
admet-2214	344	16	barriers	barrier	NOUN
admet-2214	344	17	in	in	ADP
admet-2214	344	18	diffuse	diffuse	ADJ
admet-2214	344	19	intrinsic	intrinsic	ADJ
admet-2214	344	20	pontine	pontine	ADJ
admet-2214	344	21	glioma	glioma	NOUN
admet-2214	344	22	doi	doi	NOUN
admet-2214	344	23	:	:	PUNCT
admet-2214	344	24	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	344	25	419	419	NUM
admet-2214	344	26	unaffected	unaffected	ADJ
admet-2214	344	27	by	by	ADP
admet-2214	344	28	the	the	DET
admet-2214	344	29	use	use	NOUN
admet-2214	344	30	of	of	ADP
admet-2214	344	31	1	1	NUM
admet-2214	344	32	mg	mg	NUM
admet-2214	344	33	/	/	SYM
admet-2214	344	34	ml	ml	NOUN
admet-2214	344	35	of	of	ADP
admet-2214	344	36	the	the	DET
admet-2214	344	37	cationic	cationic	ADJ
admet-2214	344	38	surfactant	surfactant	NOUN
admet-2214	344	39	cetyltrimethylammonium	cetyltrimethylammonium	NOUN
admet-2214	344	40	bromide	bromide	NOUN
admet-2214	344	41	(	(	PUNCT
admet-2214	344	42	ctab	ctab	NOUN
admet-2214	344	43	)	)	PUNCT
admet-2214	344	44	.	.	PUNCT
admet-2214	345	1	however	however	ADV
admet-2214	345	2	,	,	PUNCT
admet-2214	345	3	some	some	DET
admet-2214	345	4	studies	study	NOUN
admet-2214	345	5	have	have	AUX
admet-2214	345	6	indicated	indicate	VERB
admet-2214	345	7	that	that	SCONJ
admet-2214	345	8	cationic	cationic	ADJ
admet-2214	345	9	surfactants	surfactant	NOUN
admet-2214	345	10	impact	impact	VERB
admet-2214	345	11	the	the	DET
admet-2214	345	12	cell	cell	NOUN
admet-2214	345	13	membrane	membrane	NOUN
admet-2214	345	14	's	's	PART
admet-2214	345	15	integrity	integrity	NOUN
admet-2214	345	16	[	[	X
admet-2214	345	17	106	106	NUM
admet-2214	345	18	]	]	PUNCT
admet-2214	345	19	.	.	PUNCT
admet-2214	346	1	genotoxicity	genotoxicity	NOUN
admet-2214	346	2	the	the	DET
admet-2214	346	3	most	most	ADV
admet-2214	346	4	important	important	ADJ
admet-2214	346	5	model	model	NOUN
admet-2214	346	6	in	in	ADP
admet-2214	346	7	this	this	DET
admet-2214	346	8	case	case	NOUN
admet-2214	346	9	is	be	AUX
admet-2214	346	10	the	the	DET
admet-2214	346	11	induction	induction	NOUN
admet-2214	346	12	of	of	ADP
admet-2214	346	13	dna	dna	PROPN
admet-2214	346	14	damage	damage	NOUN
admet-2214	346	15	because	because	SCONJ
admet-2214	346	16	exemplary	exemplary	ADJ
admet-2214	346	17	genotoxins	genotoxin	NOUN
admet-2214	346	18	can	can	AUX
admet-2214	346	19	cause	cause	VERB
admet-2214	346	20	genetic	genetic	ADJ
admet-2214	346	21	alterations	alteration	NOUN
admet-2214	346	22	without	without	ADP
admet-2214	346	23	causing	cause	VERB
admet-2214	346	24	cell	cell	NOUN
admet-2214	346	25	death	death	NOUN
admet-2214	346	26	,	,	PUNCT
admet-2214	346	27	which	which	PRON
admet-2214	346	28	can	can	AUX
admet-2214	346	29	initiate	initiate	VERB
admet-2214	346	30	carcinogenesis	carcinogenesis	NOUN
admet-2214	346	31	.	.	PUNCT
admet-2214	347	1	however	however	ADV
admet-2214	347	2	,	,	PUNCT
admet-2214	347	3	there	there	PRON
admet-2214	347	4	are	be	VERB
admet-2214	347	5	many	many	ADJ
admet-2214	347	6	studies	study	NOUN
admet-2214	347	7	reporting	report	VERB
admet-2214	347	8	that	that	SCONJ
admet-2214	347	9	lipid	lipid	NOUN
admet-2214	347	10	-	-	PUNCT
admet-2214	347	11	based	base	VERB
admet-2214	347	12	nanoparticles	nanoparticle	NOUN
admet-2214	347	13	produce	produce	VERB
admet-2214	347	14	no	no	DET
admet-2214	347	15	genotoxicity	genotoxicity	NOUN
admet-2214	347	16	.	.	PUNCT
admet-2214	348	1	one	one	NUM
admet-2214	348	2	study	study	NOUN
admet-2214	348	3	reported	report	VERB
admet-2214	348	4	that	that	SCONJ
admet-2214	348	5	no	no	DET
admet-2214	348	6	dna	dna	PROPN
admet-2214	348	7	damage	damage	NOUN
admet-2214	348	8	was	be	AUX
admet-2214	348	9	observed	observe	VERB
admet-2214	348	10	in	in	ADP
admet-2214	348	11	a549	a549	PROPN
admet-2214	348	12	cells	cell	NOUN
admet-2214	348	13	by	by	ADP
admet-2214	348	14	the	the	DET
admet-2214	348	15	negatively	negatively	ADV
admet-2214	348	16	charged	charge	VERB
admet-2214	348	17	slns	slns	NOUN
admet-2214	349	1	[	[	X
admet-2214	349	2	107,108	107,108	NUM
admet-2214	349	3	]	]	PUNCT
admet-2214	349	4	.	.	PUNCT
admet-2214	350	1	however	however	ADV
admet-2214	350	2	,	,	PUNCT
admet-2214	350	3	the	the	DET
admet-2214	350	4	drug	drug	NOUN
admet-2214	350	5	and	and	CCONJ
admet-2214	350	6	drugloaded	drugloade	VERB
admet-2214	350	7	slns	slns	ADV
admet-2214	350	8	reduced	reduce	VERB
admet-2214	350	9	cell	cell	NOUN
admet-2214	350	10	viability	viability	NOUN
admet-2214	350	11	below	below	ADP
admet-2214	350	12	50	50	NUM
admet-2214	350	13	%	%	NOUN
admet-2214	350	14	at	at	ADP
admet-2214	350	15	the	the	DET
admet-2214	350	16	concentration	concentration	NOUN
admet-2214	350	17	chosen	choose	VERB
admet-2214	350	18	for	for	ADP
admet-2214	350	19	genotoxicity	genotoxicity	NOUN
admet-2214	350	20	testing	testing	NOUN
admet-2214	350	21	[	[	X
admet-2214	350	22	109	109	NUM
admet-2214	350	23	]	]	PUNCT
admet-2214	350	24	.	.	PUNCT
admet-2214	351	1	hepatotoxicity	hepatotoxicity	NOUN
admet-2214	351	2	when	when	SCONJ
admet-2214	351	3	a	a	DET
admet-2214	351	4	formulation	formulation	NOUN
admet-2214	351	5	enters	enter	VERB
admet-2214	351	6	the	the	DET
admet-2214	351	7	bloodstream	bloodstream	NOUN
admet-2214	351	8	,	,	PUNCT
admet-2214	351	9	it	it	PRON
admet-2214	351	10	is	be	AUX
admet-2214	351	11	very	very	ADV
admet-2214	351	12	important	important	ADJ
admet-2214	351	13	to	to	PART
admet-2214	351	14	check	check	VERB
admet-2214	351	15	whether	whether	SCONJ
admet-2214	351	16	the	the	DET
admet-2214	351	17	rbc	rbc	PROPN
admet-2214	351	18	cells	cell	NOUN
admet-2214	351	19	are	be	AUX
admet-2214	351	20	damaged	damage	VERB
admet-2214	351	21	and	and	CCONJ
admet-2214	351	22	to	to	PART
admet-2214	351	23	ensure	ensure	VERB
admet-2214	351	24	this	this	DET
admet-2214	351	25	hemolysis	hemolysis	NOUN
admet-2214	351	26	assay	assay	NOUN
admet-2214	351	27	is	be	AUX
admet-2214	351	28	performed	perform	VERB
admet-2214	351	29	,	,	PUNCT
admet-2214	351	30	which	which	PRON
admet-2214	351	31	determines	determine	VERB
admet-2214	351	32	the	the	DET
admet-2214	351	33	damage	damage	NOUN
admet-2214	351	34	of	of	ADP
admet-2214	351	35	rbc	rbc	PROPN
admet-2214	351	36	that	that	SCONJ
admet-2214	351	37	a	a	DET
admet-2214	351	38	foreign	foreign	ADJ
admet-2214	351	39	material	material	NOUN
admet-2214	351	40	causes	cause	VERB
admet-2214	351	41	[	[	X
admet-2214	351	42	75	75	NUM
admet-2214	351	43	]	]	PUNCT
admet-2214	351	44	.	.	PUNCT
admet-2214	352	1	a	a	DET
admet-2214	352	2	study	study	NOUN
admet-2214	352	3	revealed	reveal	VERB
admet-2214	352	4	that	that	SCONJ
admet-2214	352	5	even	even	ADV
admet-2214	352	6	at	at	ADP
admet-2214	352	7	a	a	DET
admet-2214	352	8	dose	dose	NOUN
admet-2214	352	9	of	of	ADP
admet-2214	352	10	1	1	NUM
admet-2214	352	11	mg	mg	NUM
admet-2214	352	12	/	/	SYM
admet-2214	352	13	ml	ml	PROPN
admet-2214	352	14	,	,	PUNCT
admet-2214	352	15	the	the	DET
admet-2214	352	16	slns	slns	NOUN
admet-2214	352	17	made	make	VERB
admet-2214	352	18	of	of	ADP
admet-2214	352	19	polysorbate	polysorbate	NOUN
admet-2214	352	20	80	80	NUM
admet-2214	352	21	and	and	CCONJ
admet-2214	352	22	glycerol	glycerol	NOUN
admet-2214	352	23	monostearate	monostearate	NOUN
admet-2214	352	24	exhibit	exhibit	VERB
admet-2214	352	25	minimal	minimal	ADJ
admet-2214	352	26	hemolysis	hemolysis	NOUN
admet-2214	352	27	[	[	X
admet-2214	352	28	110	110	NUM
admet-2214	352	29	]	]	PUNCT
admet-2214	352	30	.	.	PUNCT
admet-2214	353	1	nano	nano	NOUN
admet-2214	353	2	-	-	PUNCT
admet-2214	353	3	based	base	VERB
admet-2214	353	4	drug	drug	NOUN
admet-2214	353	5	approved	approve	VERB
admet-2214	353	6	for	for	ADP
admet-2214	353	7	cancer	cancer	NOUN
admet-2214	353	8	therapy	therapy	NOUN
admet-2214	353	9	by	by	ADP
admet-2214	353	10	regulatory	regulatory	ADJ
admet-2214	353	11	authorities	authority	NOUN
admet-2214	353	12	.	.	PUNCT
admet-2214	354	1	the	the	DET
admet-2214	354	2	first	first	ADJ
admet-2214	354	3	drug	drug	NOUN
admet-2214	354	4	delivery	delivery	NOUN
admet-2214	354	5	systems	system	NOUN
admet-2214	354	6	to	to	PART
admet-2214	354	7	be	be	AUX
admet-2214	354	8	launched	launch	VERB
admet-2214	354	9	in	in	ADP
admet-2214	354	10	the	the	DET
admet-2214	354	11	market	market	NOUN
admet-2214	354	12	for	for	ADP
admet-2214	354	13	cancer	cancer	NOUN
admet-2214	354	14	treatment	treatment	NOUN
admet-2214	354	15	were	be	AUX
admet-2214	354	16	liposomes	liposome	NOUN
admet-2214	354	17	and	and	CCONJ
admet-2214	354	18	are	be	AUX
admet-2214	354	19	still	still	ADV
admet-2214	354	20	most	most	ADV
admet-2214	354	21	widely	widely	ADV
admet-2214	354	22	used	use	VERB
admet-2214	354	23	due	due	ADP
admet-2214	354	24	to	to	ADP
admet-2214	354	25	their	their	PRON
admet-2214	354	26	several	several	ADJ
admet-2214	354	27	positive	positive	ADJ
admet-2214	354	28	points	point	NOUN
admet-2214	354	29	such	such	ADJ
admet-2214	354	30	as	as	ADP
admet-2214	354	31	biocompatibility	biocompatibility	NOUN
admet-2214	354	32	,	,	PUNCT
admet-2214	354	33	biodegradability	biodegradability	NOUN
admet-2214	354	34	and	and	CCONJ
admet-2214	354	35	non	non	NOUN
admet-2214	354	36	-	-	NOUN
admet-2214	354	37	immunogenicity	immunogenicity	NOUN
admet-2214	354	38	[	[	X
admet-2214	354	39	111,112	111,112	NUM
admet-2214	354	40	]	]	PUNCT
admet-2214	354	41	.	.	PUNCT
admet-2214	355	1	the	the	DET
admet-2214	355	2	approved	approve	VERB
admet-2214	355	3	nano	nano	NOUN
admet-2214	355	4	-	-	PUNCT
admet-2214	355	5	based	base	VERB
admet-2214	355	6	formulations	formulation	NOUN
admet-2214	355	7	for	for	ADP
admet-2214	355	8	brain	brain	NOUN
admet-2214	355	9	cancer	cancer	NOUN
admet-2214	355	10	treatment	treatment	NOUN
admet-2214	355	11	are	be	AUX
admet-2214	355	12	listed	list	VERB
admet-2214	355	13	in	in	ADP
admet-2214	355	14	table	table	NOUN
admet-2214	355	15	6	6	NUM
admet-2214	355	16	.	.	PUNCT
admet-2214	355	17	table	table	NOUN
admet-2214	355	18	6	6	NUM
admet-2214	355	19	.	.	PUNCT
admet-2214	355	20	approved	approve	VERB
admet-2214	355	21	nano	nano	NOUN
admet-2214	355	22	-	-	PUNCT
admet-2214	355	23	based	base	VERB
admet-2214	355	24	products	product	NOUN
admet-2214	355	25	for	for	ADP
admet-2214	355	26	brain	brain	NOUN
admet-2214	355	27	cancer	cancer	NOUN
admet-2214	355	28	producttm	producttm	NOUN
admet-2214	355	29	drug	drug	NOUN
admet-2214	355	30	dosage	dosage	NOUN
admet-2214	355	31	form	form	NOUN
admet-2214	355	32	company	company	NOUN
admet-2214	355	33	approval	approval	NOUN
admet-2214	355	34	year	year	NOUN
admet-2214	355	35	doxil	doxil	NOUN
admet-2214	356	1	[	[	X
admet-2214	356	2	113	113	NUM
admet-2214	356	3	]	]	PUNCT
admet-2214	356	4	doxorubiicn	doxorubiicn	NOUN
admet-2214	356	5	liposome	liposome	NOUN
admet-2214	356	6	ortho	ortho	PROPN
admet-2214	356	7	biotech	biotech	PROPN
admet-2214	356	8	1995	1995	NUM
admet-2214	356	9	(	(	PUNCT
admet-2214	356	10	fda	fda	PROPN
admet-2214	356	11	)	)	PUNCT
admet-2214	356	12	caelyx	caelyx	NOUN
admet-2214	357	1	[	[	X
admet-2214	357	2	114	114	NUM
admet-2214	357	3	]	]	PUNCT
admet-2214	357	4	doxorubicin	doxorubicin	PROPN
admet-2214	357	5	liposome	liposome	VERB
admet-2214	357	6	schering	schering	NOUN
admet-2214	357	7	-	-	PUNCT
admet-2214	357	8	plough	plough	NOUN
admet-2214	357	9	1996	1996	NUM
admet-2214	357	10	(	(	PUNCT
admet-2214	357	11	ema	ema	PROPN
admet-2214	357	12	)	)	PUNCT
admet-2214	357	13	daunoxome	daunoxome	NOUN
admet-2214	358	1	[	[	X
admet-2214	358	2	115	115	NUM
admet-2214	358	3	]	]	X
admet-2214	358	4	daunorubicin	daunorubicin	NOUN
admet-2214	358	5	liposome	liposome	VERB
admet-2214	358	6	galen	galen	PROPN
admet-2214	358	7	1996	1996	NUM
admet-2214	358	8	(	(	PUNCT
admet-2214	358	9	fda	fda	PROPN
admet-2214	358	10	)	)	PUNCT
admet-2214	358	11	myocet	myocet	NOUN
admet-2214	359	1	[	[	X
admet-2214	359	2	114	114	NUM
admet-2214	359	3	]	]	PUNCT
admet-2214	359	4	doxorubicin	doxorubicin	PROPN
admet-2214	359	5	liposome	liposome	PROPN
admet-2214	359	6	teva	teva	PROPN
admet-2214	359	7	uk	uk	PROPN
admet-2214	359	8	2000	2000	NUM
admet-2214	359	9	(	(	PUNCT
admet-2214	359	10	ema	ema	PROPN
admet-2214	359	11	)	)	PUNCT
admet-2214	359	12	mepact	mepact	NOUN
admet-2214	360	1	[	[	X
admet-2214	360	2	116	116	NUM
admet-2214	360	3	]	]	X
admet-2214	360	4	mifamurtide	mifamurtide	NOUN
admet-2214	360	5	liposome	liposome	PROPN
admet-2214	360	6	millenium	millenium	PROPN
admet-2214	360	7	2009	2009	NUM
admet-2214	360	8	(	(	PUNCT
admet-2214	360	9	ema	ema	PROPN
admet-2214	360	10	)	)	PUNCT
admet-2214	360	11	ameluz	ameluz	NOUN
admet-2214	360	12	[	[	X
admet-2214	360	13	117	117	NUM
admet-2214	360	14	]	]	SYM
admet-2214	360	15	5	5	NUM
admet-2214	360	16	-	-	PUNCT
admet-2214	360	17	aminolevulinic	aminolevulinic	ADJ
admet-2214	360	18	acid	acid	NOUN
admet-2214	360	19	nanoemulsion	nanoemulsion	NOUN
admet-2214	360	20	biofrontra	biofrontra	PROPN
admet-2214	360	21	gmbh	gmbh	PROPN
admet-2214	360	22	2011	2011	NUM
admet-2214	360	23	(	(	PUNCT
admet-2214	360	24	ema	ema	PROPN
admet-2214	360	25	)	)	PUNCT
admet-2214	360	26	marquibo	marquibo	VERB
admet-2214	360	27	[	[	PUNCT
admet-2214	360	28	118	118	NUM
admet-2214	360	29	]	]	PUNCT
admet-2214	360	30	vincristine	vincristine	NOUN
admet-2214	360	31	liposome	liposome	NOUN
admet-2214	360	32	spectrum	spectrum	NOUN
admet-2214	360	33	2012	2012	NUM
admet-2214	360	34	(	(	PUNCT
admet-2214	360	35	fda	fda	PROPN
admet-2214	360	36	)	)	PUNCT
admet-2214	360	37	nanotherm	nanotherm	NOUN
admet-2214	360	38	iron	iron	NOUN
admet-2214	360	39	oxide	oxide	NOUN
admet-2214	360	40	/	/	SYM
admet-2214	360	41	ferric	ferric	ADJ
admet-2214	360	42	oxide	oxide	NOUN
admet-2214	360	43	metallic	metallic	ADJ
admet-2214	360	44	nanoparticles	nanoparticle	NOUN
admet-2214	360	45	magforce	magforce	PROPN
admet-2214	360	46	2013	2013	NUM
admet-2214	360	47	(	(	PUNCT
admet-2214	360	48	ema	ema	PROPN
admet-2214	360	49	)	)	PUNCT
admet-2214	360	50	onivyde	onivyde	VERB
admet-2214	361	1	[	[	X
admet-2214	361	2	119	119	NUM
admet-2214	361	3	]	]	X
admet-2214	361	4	irinotecan	irinotecan	NOUN
admet-2214	361	5	liposome	liposome	VERB
admet-2214	361	6	merrimack	merrimack	PROPN
admet-2214	361	7	2015(fda	2015(fda	NUM
admet-2214	361	8	)	)	PUNCT
admet-2214	361	9	vyxeos	vyxeo	NOUN
admet-2214	361	10	daunorubicin	daunorubicin	VERB
admet-2214	361	11	,	,	PUNCT
admet-2214	361	12	cytarabine	cytarabine	NOUN
admet-2214	361	13	liposome	liposome	VERB
admet-2214	361	14	jazz	jazz	NOUN
admet-2214	361	15	pharmaceuticals	pharmaceutical	NOUN
admet-2214	361	16	2018	2018	NUM
admet-2214	361	17	(	(	PUNCT
admet-2214	361	18	ema	ema	PROPN
admet-2214	361	19	)	)	PUNCT
admet-2214	361	20	clinical	clinical	ADJ
admet-2214	361	21	trials	trial	NOUN
admet-2214	361	22	for	for	ADP
admet-2214	361	23	dipg	dipg	NOUN
admet-2214	361	24	as	as	ADP
admet-2214	361	25	per	per	ADP
admet-2214	361	26	clinicaltrials.org	clinicaltrials.org	X
admet-2214	361	27	(	(	PUNCT
admet-2214	361	28	last	last	ADV
admet-2214	361	29	accessed	access	VERB
admet-2214	361	30	on	on	ADP
admet-2214	361	31	20/10/2023	20/10/2023	NUM
admet-2214	361	32	,	,	PUNCT
admet-2214	361	33	there	there	PRON
admet-2214	361	34	are	be	VERB
admet-2214	361	35	116	116	NUM
admet-2214	361	36	studies	study	NOUN
admet-2214	361	37	conducted	conduct	VERB
admet-2214	361	38	for	for	ADP
admet-2214	361	39	dipg	dipg	NOUN
admet-2214	361	40	,	,	PUNCT
admet-2214	361	41	out	out	ADP
admet-2214	361	42	of	of	ADP
admet-2214	361	43	which	which	PRON
admet-2214	361	44	only	only	ADV
admet-2214	361	45	34	34	NUM
admet-2214	361	46	no	no	NOUN
admet-2214	361	47	.	.	PUNCT
admet-2214	362	1	of	of	ADP
admet-2214	362	2	studies	study	NOUN
admet-2214	362	3	are	be	AUX
admet-2214	362	4	completed	complete	VERB
admet-2214	362	5	up	up	ADP
admet-2214	362	6	to	to	ADP
admet-2214	362	7	date	date	NOUN
admet-2214	362	8	and	and	CCONJ
admet-2214	362	9	40	40	NUM
admet-2214	362	10	studies	study	NOUN
admet-2214	362	11	are	be	AUX
admet-2214	362	12	found	find	VERB
admet-2214	362	13	to	to	PART
admet-2214	362	14	be	be	AUX
admet-2214	362	15	recruiting	recruit	VERB
admet-2214	362	16	,	,	PUNCT
admet-2214	362	17	presented	present	VERB
admet-2214	362	18	in	in	ADP
admet-2214	362	19	figure	figure	NOUN
admet-2214	362	20	13	13	NUM
admet-2214	363	1	[	[	X
admet-2214	363	2	120	120	NUM
admet-2214	363	3	]	]	PUNCT
admet-2214	363	4	.	.	PUNCT
admet-2214	364	1	figure	figure	NOUN
admet-2214	364	2	13	13	NUM
admet-2214	364	3	.	.	PUNCT
admet-2214	365	1	graphical	graphical	ADJ
admet-2214	365	2	representation	representation	NOUN
admet-2214	365	3	of	of	ADP
admet-2214	365	4	clinical	clinical	ADJ
admet-2214	365	5	trials	trial	NOUN
admet-2214	365	6	going	go	VERB
admet-2214	365	7	on	on	ADP
admet-2214	365	8	for	for	ADP
admet-2214	366	1	dipg	dipg	PROPN
admet-2214	366	2	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	366	3	z.	z.	PROPN
admet-2214	366	4	presswala	presswala	PROPN
admet-2214	366	5	et	et	PROPN
admet-2214	366	6	al	al	PROPN
admet-2214	366	7	.	.	PROPN
admet-2214	366	8	admet	admet	PROPN
admet-2214	366	9	&	&	CCONJ
admet-2214	366	10	dmpk	dmpk	PROPN
admet-2214	366	11	12(3	12(3	PROPN
admet-2214	366	12	)	)	PUNCT
admet-2214	366	13	(	(	PUNCT
admet-2214	366	14	2024	2024	NUM
admet-2214	366	15	)	)	PUNCT
admet-2214	366	16	403	403	NUM
admet-2214	366	17	-	-	SYM
admet-2214	366	18	429	429	NUM
admet-2214	366	19	420	420	NUM
admet-2214	366	20	table	table	NOUN
admet-2214	366	21	7	7	NUM
admet-2214	366	22	,	,	PUNCT
admet-2214	366	23	provided	provide	VERB
admet-2214	366	24	below	below	ADV
admet-2214	366	25	,	,	PUNCT
admet-2214	366	26	presents	present	VERB
admet-2214	366	27	a	a	DET
admet-2214	366	28	comprehensive	comprehensive	ADJ
admet-2214	366	29	overview	overview	NOUN
admet-2214	366	30	of	of	ADP
admet-2214	366	31	the	the	DET
admet-2214	366	32	studies	study	NOUN
admet-2214	366	33	that	that	PRON
admet-2214	366	34	have	have	AUX
admet-2214	366	35	been	be	AUX
admet-2214	366	36	completed	complete	VERB
admet-2214	366	37	since	since	SCONJ
admet-2214	366	38	2020	2020	NUM
admet-2214	366	39	.	.	PUNCT
admet-2214	367	1	table	table	NOUN
admet-2214	367	2	7	7	NUM
admet-2214	367	3	.	.	PUNCT
admet-2214	368	1	clinical	clinical	ADJ
admet-2214	368	2	studies	study	NOUN
admet-2214	368	3	completed	complete	VERB
admet-2214	368	4	in	in	ADP
admet-2214	368	5	dipg	dipg	NOUN
admet-2214	368	6	description	description	NOUN
admet-2214	368	7	drug	drug	NOUN
admet-2214	368	8	formulation	formulation	NOUN
admet-2214	368	9	clinicaltrials.gov	clinicaltrials.gov	PUNCT
admet-2214	368	10	identifier	identifier	NOUN
admet-2214	368	11	in	in	ADP
admet-2214	368	12	this	this	DET
admet-2214	368	13	phase	phase	NOUN
admet-2214	368	14	i	i	PROPN
admet-2214	368	15	/	/	SYM
admet-2214	368	16	ii	ii	PROPN
admet-2214	368	17	trial	trial	NOUN
admet-2214	368	18	,	,	PUNCT
admet-2214	368	19	patients	patient	NOUN
admet-2214	368	20	with	with	ADP
admet-2214	368	21	a	a	DET
admet-2214	368	22	recently	recently	ADV
admet-2214	368	23	diagnosed	diagnose	VERB
admet-2214	368	24	diffuse	diffuse	NOUN
admet-2214	368	25	intrinsic	intrinsic	ADJ
admet-2214	368	26	pontine	pontine	ADJ
admet-2214	368	27	glioma	glioma	NOUN
admet-2214	368	28	are	be	AUX
admet-2214	368	29	treated	treat	VERB
admet-2214	368	30	,	,	PUNCT
admet-2214	368	31	and	and	CCONJ
admet-2214	368	32	the	the	DET
admet-2214	368	33	side	side	NOUN
admet-2214	368	34	effects	effect	NOUN
admet-2214	368	35	of	of	ADP
admet-2214	368	36	the	the	DET
admet-2214	368	37	panobinostat	panobinostat	NOUN
admet-2214	368	38	nanoparticle	nanoparticle	NOUN
admet-2214	368	39	formulation	formulation	NOUN
admet-2214	368	40	mtx110	mtx110	PROPN
admet-2214	368	41	(	(	PUNCT
admet-2214	368	42	mtx110	mtx110	NOUN
admet-2214	368	43	)	)	PUNCT
admet-2214	368	44	are	be	AUX
admet-2214	368	45	investigated	investigate	VERB
admet-2214	368	46	.	.	PUNCT
admet-2214	369	1	through	through	ADP
admet-2214	369	2	the	the	DET
admet-2214	369	3	inhibition	inhibition	NOUN
admet-2214	369	4	of	of	ADP
admet-2214	369	5	certain	certain	ADJ
admet-2214	369	6	enzymes	enzyme	NOUN
admet-2214	369	7	required	require	VERB
admet-2214	369	8	for	for	ADP
admet-2214	369	9	cell	cell	NOUN
admet-2214	369	10	growth	growth	NOUN
admet-2214	369	11	,	,	PUNCT
admet-2214	369	12	the	the	DET
admet-2214	369	13	panobinostat	panobinostat	NOUN
admet-2214	369	14	nanoparticle	nanoparticle	NOUN
admet-2214	369	15	formulation	formulation	NOUN
admet-2214	369	16	mtx110	mtx110	PROPN
admet-2214	369	17	may	may	AUX
admet-2214	369	18	be	be	AUX
admet-2214	369	19	able	able	ADJ
admet-2214	369	20	to	to	PART
admet-2214	369	21	stop	stop	VERB
admet-2214	369	22	the	the	DET
admet-2214	369	23	proliferation	proliferation	NOUN
admet-2214	369	24	of	of	ADP
admet-2214	369	25	tumor	tumor	NOUN
admet-2214	369	26	cells	cell	NOUN
admet-2214	369	27	.	.	PUNCT
admet-2214	370	1	panobinostat	panobinostat	NOUN
admet-2214	370	2	convection	convection	NOUN
admet-2214	370	3	enhanced	enhance	VERB
admet-2214	370	4	delivery	delivery	NOUN
admet-2214	370	5	nanoparticles	nanoparticle	NOUN
admet-2214	370	6	nct03566199	nct03566199	VERB
admet-2214	370	7	in	in	ADP
admet-2214	370	8	children	child	NOUN
admet-2214	370	9	with	with	ADP
admet-2214	370	10	diffuse	diffuse	NOUN
admet-2214	370	11	intrinsic	intrinsic	ADJ
admet-2214	370	12	pontine	pontine	ADJ
admet-2214	370	13	glioma	glioma	NOUN
admet-2214	370	14	who	who	PRON
admet-2214	370	15	have	have	AUX
admet-2214	370	16	finished	finish	VERB
admet-2214	370	17	focused	focused	ADJ
admet-2214	370	18	radiation	radiation	NOUN
admet-2214	370	19	therapy	therapy	NOUN
admet-2214	370	20	,	,	PUNCT
admet-2214	370	21	this	this	PRON
admet-2214	370	22	is	be	AUX
admet-2214	370	23	a	a	DET
admet-2214	370	24	phase	phase	NOUN
admet-2214	370	25	i	i	PRON
admet-2214	370	26	and	and	CCONJ
admet-2214	370	27	early	early	ADJ
admet-2214	370	28	efficacy	efficacy	NOUN
admet-2214	370	29	study	study	NOUN
admet-2214	370	30	using	use	VERB
admet-2214	370	31	convection	convection	NOUN
admet-2214	370	32	enhanced	enhance	VERB
admet-2214	370	33	delivery	delivery	NOUN
admet-2214	370	34	(	(	PUNCT
admet-2214	370	35	ced	ced	PROPN
admet-2214	370	36	)	)	PUNCT
admet-2214	370	37	of	of	ADP
admet-2214	370	38	irinotecan	irinotecan	NOUN
admet-2214	370	39	liposome	liposome	VERB
admet-2214	370	40	injection	injection	NOUN
admet-2214	370	41	(	(	PUNCT
admet-2214	370	42	nal	nal	NOUN
admet-2214	370	43	-	-	PUNCT
admet-2214	370	44	iri	iri	NOUN
admet-2214	370	45	)	)	PUNCT
admet-2214	370	46	using	use	VERB
admet-2214	370	47	real	real	ADJ
admet-2214	370	48	time	time	NOUN
admet-2214	370	49	imaging	imaging	NOUN
admet-2214	370	50	with	with	ADP
admet-2214	370	51	gadolinium	gadolinium	NOUN
admet-2214	370	52	.	.	PUNCT
admet-2214	371	1	irinotecan	irinotecan	PROPN
admet-2214	371	2	convection	convection	PROPN
admet-2214	371	3	enhanced	enhance	VERB
admet-2214	371	4	delivery	delivery	NOUN
admet-2214	371	5	liposomes	liposome	NOUN
admet-2214	371	6	nct03086616	nct03086616	ADV
admet-2214	371	7	table	table	VERB
admet-2214	371	8	8	8	NUM
admet-2214	371	9	presents	present	VERB
admet-2214	371	10	a	a	DET
admet-2214	371	11	comprehensive	comprehensive	ADJ
admet-2214	371	12	overview	overview	NOUN
admet-2214	371	13	of	of	ADP
admet-2214	371	14	ongoing	ongoing	ADJ
admet-2214	371	15	studies	study	NOUN
admet-2214	371	16	that	that	PRON
admet-2214	371	17	have	have	AUX
admet-2214	371	18	been	be	AUX
admet-2214	371	19	actively	actively	ADV
admet-2214	371	20	recruiting	recruit	VERB
admet-2214	371	21	participants	participant	NOUN
admet-2214	371	22	since	since	SCONJ
admet-2214	371	23	the	the	DET
admet-2214	371	24	year	year	NOUN
admet-2214	371	25	2020	2020	NUM
admet-2214	371	26	.	.	PUNCT
admet-2214	372	1	table	table	NOUN
admet-2214	372	2	8	8	NUM
admet-2214	372	3	.	.	PUNCT
admet-2214	373	1	on	on	ADP
admet-2214	373	2	going	go	VERB
admet-2214	373	3	clinical	clinical	ADJ
admet-2214	373	4	studies	study	NOUN
admet-2214	373	5	completed	complete	VERB
admet-2214	373	6	in	in	ADP
admet-2214	373	7	dipg	dipg	NOUN
admet-2214	373	8	description	description	NOUN
admet-2214	373	9	drug	drug	NOUN
admet-2214	373	10	clinicaltrials.gov	clinicaltrials.gov	PUNCT
admet-2214	373	11	identifier	identifier	NOUN
admet-2214	373	12	in	in	ADP
admet-2214	373	13	children	child	NOUN
admet-2214	373	14	recently	recently	ADV
admet-2214	373	15	diagnosed	diagnose	VERB
admet-2214	373	16	with	with	ADP
admet-2214	373	17	diffuse	diffuse	NOUN
admet-2214	373	18	intrinsic	intrinsic	ADJ
admet-2214	373	19	pontine	pontine	ADJ
admet-2214	373	20	glioma	glioma	NOUN
admet-2214	373	21	(	(	PUNCT
admet-2214	373	22	dipg	dipg	PROPN
admet-2214	373	23	)	)	PUNCT
admet-2214	373	24	,	,	PUNCT
admet-2214	373	25	the	the	DET
admet-2214	373	26	purpose	purpose	NOUN
admet-2214	373	27	of	of	ADP
admet-2214	373	28	this	this	DET
admet-2214	373	29	prospective	prospective	ADJ
admet-2214	373	30	,	,	PUNCT
admet-2214	373	31	open	open	ADJ
admet-2214	373	32	-	-	PUNCT
admet-2214	373	33	label	label	NOUN
admet-2214	373	34	,	,	PUNCT
admet-2214	373	35	single	single	ADJ
admet-2214	373	36	-	-	PUNCT
admet-2214	373	37	arm	arm	NOUN
admet-2214	373	38	,	,	PUNCT
admet-2214	373	39	multicenter	multicenter	ADJ
admet-2214	373	40	clinical	clinical	ADJ
admet-2214	373	41	research	research	NOUN
admet-2214	373	42	is	be	AUX
admet-2214	373	43	to	to	PART
admet-2214	373	44	evaluate	evaluate	VERB
admet-2214	373	45	the	the	DET
admet-2214	373	46	safety	safety	NOUN
admet-2214	373	47	and	and	CCONJ
admet-2214	373	48	therapeutic	therapeutic	ADJ
admet-2214	373	49	efficacy	efficacy	NOUN
admet-2214	373	50	of	of	ADP
admet-2214	373	51	combining	combine	VERB
admet-2214	373	52	nimotuzumab	nimotuzumab	NOUN
admet-2214	373	53	with	with	ADP
admet-2214	373	54	concurrent	concurrent	ADJ
admet-2214	373	55	radiochemotherapy	radiochemotherapy	NOUN
admet-2214	373	56	.	.	PUNCT
admet-2214	374	1	the	the	DET
admet-2214	374	2	objective	objective	ADJ
admet-2214	374	3	response	response	NOUN
admet-2214	374	4	rate	rate	NOUN
admet-2214	374	5	serves	serve	VERB
admet-2214	374	6	as	as	ADP
admet-2214	374	7	the	the	DET
admet-2214	374	8	main	main	ADJ
admet-2214	374	9	outcome	outcome	NOUN
admet-2214	374	10	,	,	PUNCT
admet-2214	374	11	while	while	SCONJ
admet-2214	374	12	the	the	DET
admet-2214	374	13	1year	1year	NUM
admet-2214	374	14	overall	overall	ADJ
admet-2214	374	15	survival	survival	NOUN
admet-2214	374	16	rate	rate	NOUN
admet-2214	374	17	is	be	AUX
admet-2214	374	18	a	a	DET
admet-2214	374	19	seconddary	seconddary	ADJ
admet-2214	374	20	observation	observation	NOUN
admet-2214	374	21	.	.	PUNCT
admet-2214	375	1	the	the	DET
admet-2214	375	2	study	study	NOUN
admet-2214	375	3	tackles	tackle	VERB
admet-2214	375	4	the	the	DET
admet-2214	375	5	necessity	necessity	NOUN
admet-2214	375	6	of	of	ADP
admet-2214	375	7	assessing	assess	VERB
admet-2214	375	8	the	the	DET
admet-2214	375	9	combination	combination	NOUN
admet-2214	375	10	therapy	therapy	NOUN
admet-2214	375	11	's	's	PART
admet-2214	375	12	possible	possible	ADJ
admet-2214	375	13	advantages	advantage	NOUN
admet-2214	375	14	and	and	CCONJ
admet-2214	375	15	safety	safety	NOUN
admet-2214	375	16	in	in	ADP
admet-2214	375	17	treating	treat	VERB
admet-2214	375	18	juvenile	juvenile	ADJ
admet-2214	375	19	dipg	dipg	NOUN
admet-2214	375	20	patients	patient	NOUN
admet-2214	375	21	.	.	PUNCT
admet-2214	376	1	nimotuzumab+	nimotuzumab+	X
admet-2214	376	2	crt	crt	ADJ
admet-2214	376	3	(	(	PUNCT
admet-2214	376	4	concurrent	concurrent	ADJ
admet-2214	376	5	imrt	imrt	NOUN
admet-2214	376	6	and	and	CCONJ
admet-2214	376	7	tmz	tmz	PROPN
admet-2214	376	8	)	)	PUNCT
admet-2214	376	9	nct04532229	nct04532229	AUX
admet-2214	376	10	this	this	DET
admet-2214	376	11	work	work	NOUN
admet-2214	376	12	investigates	investigate	VERB
admet-2214	376	13	gemcitabine	gemcitabine	NOUN
admet-2214	376	14	,	,	PUNCT
admet-2214	376	15	which	which	PRON
admet-2214	376	16	has	have	AUX
admet-2214	376	17	been	be	AUX
admet-2214	376	18	shown	show	VERB
admet-2214	376	19	to	to	PART
admet-2214	376	20	effectively	effectively	ADV
admet-2214	376	21	penetrate	penetrate	VERB
admet-2214	376	22	the	the	DET
admet-2214	376	23	blood	blood	NOUN
admet-2214	376	24	-	-	PUNCT
admet-2214	376	25	brain	brain	NOUN
admet-2214	376	26	barrier	barrier	NOUN
admet-2214	376	27	and	and	CCONJ
admet-2214	376	28	inhibit	inhibit	VERB
admet-2214	376	29	dipg	dipg	NOUN
admet-2214	376	30	cell	cell	NOUN
admet-2214	376	31	lines	line	NOUN
admet-2214	376	32	.	.	PUNCT
admet-2214	377	1	gemcitabine	gemcitabine	NOUN
admet-2214	377	2	presence	presence	NOUN
admet-2214	377	3	in	in	ADP
admet-2214	377	4	dipg	dipg	NOUN
admet-2214	377	5	tissue	tissue	NOUN
admet-2214	377	6	after	after	SCONJ
admet-2214	377	7	systemic	systemic	ADJ
admet-2214	377	8	treatment	treatment	NOUN
admet-2214	377	9	is	be	AUX
admet-2214	377	10	the	the	DET
admet-2214	377	11	main	main	ADJ
admet-2214	377	12	aim	aim	NOUN
admet-2214	377	13	,	,	PUNCT
admet-2214	377	14	whereas	whereas	SCONJ
admet-2214	377	15	intratumoral	intratumoral	ADJ
admet-2214	377	16	gemcitabine	gemcitabine	NOUN
admet-2214	377	17	concentrations	concentration	NOUN
admet-2214	377	18	are	be	AUX
admet-2214	377	19	the	the	DET
admet-2214	377	20	secondary	secondary	ADJ
admet-2214	377	21	objective	objective	NOUN
admet-2214	377	22	.	.	PUNCT
admet-2214	378	1	before	before	ADP
admet-2214	378	2	undergoing	undergo	VERB
admet-2214	378	3	routine	routine	ADJ
admet-2214	378	4	surgery	surgery	NOUN
admet-2214	378	5	,	,	PUNCT
admet-2214	378	6	participants	participant	NOUN
admet-2214	378	7	receive	receive	VERB
admet-2214	378	8	a	a	DET
admet-2214	378	9	single	single	ADJ
admet-2214	378	10	iv	iv	NUM
admet-2214	378	11	dose	dose	NOUN
admet-2214	378	12	that	that	PRON
admet-2214	378	13	makes	make	VERB
admet-2214	378	14	it	it	PRON
admet-2214	378	15	easier	easy	ADJ
admet-2214	378	16	to	to	PART
admet-2214	378	17	analyze	analyze	VERB
admet-2214	378	18	biopsy	biopsy	NOUN
admet-2214	378	19	samples	sample	NOUN
admet-2214	378	20	and	and	CCONJ
admet-2214	378	21	measure	measure	VERB
admet-2214	378	22	gemcitabine	gemcitabine	NOUN
admet-2214	378	23	penetration	penetration	NOUN
admet-2214	378	24	.	.	PUNCT
admet-2214	379	1	the	the	DET
admet-2214	379	2	purpose	purpose	NOUN
admet-2214	379	3	of	of	ADP
admet-2214	379	4	this	this	DET
admet-2214	379	5	research	research	NOUN
admet-2214	379	6	is	be	AUX
admet-2214	379	7	to	to	PART
admet-2214	379	8	overcome	overcome	VERB
admet-2214	379	9	the	the	DET
admet-2214	379	10	difficulties	difficulty	NOUN
admet-2214	379	11	associated	associate	VERB
admet-2214	379	12	with	with	ADP
admet-2214	379	13	treating	treat	VERB
admet-2214	379	14	this	this	DET
admet-2214	379	15	aggressive	aggressive	ADJ
admet-2214	379	16	pediatric	pediatric	ADJ
admet-2214	379	17	brain	brain	NOUN
admet-2214	379	18	tumor	tumor	NOUN
admet-2214	379	19	by	by	ADP
admet-2214	379	20	gaining	gain	VERB
admet-2214	379	21	understanding	understanding	NOUN
admet-2214	379	22	into	into	ADP
admet-2214	379	23	gemcitabine	gemcitabine	NOUN
admet-2214	379	24	's	's	PART
admet-2214	379	25	effectiveness	effectiveness	NOUN
admet-2214	379	26	against	against	ADP
admet-2214	379	27	dipg	dipg	PROPN
admet-2214	379	28	.	.	PUNCT
admet-2214	380	1	gemcitabine	gemcitabine	NOUN
admet-2214	380	2	nct02992015	nct02992015	VERB
admet-2214	380	3	the	the	DET
admet-2214	380	4	goal	goal	NOUN
admet-2214	380	5	of	of	ADP
admet-2214	380	6	this	this	DET
admet-2214	380	7	study	study	NOUN
admet-2214	380	8	is	be	AUX
admet-2214	380	9	to	to	PART
admet-2214	380	10	determine	determine	VERB
admet-2214	380	11	whether	whether	SCONJ
admet-2214	380	12	treating	treat	VERB
admet-2214	380	13	dipg	dipg	NOUN
admet-2214	380	14	patients	patient	NOUN
admet-2214	380	15	according	accord	VERB
admet-2214	380	16	to	to	ADP
admet-2214	380	17	the	the	DET
admet-2214	380	18	aforementioned	aforementioned	ADJ
admet-2214	380	19	methodology	methodology	NOUN
admet-2214	380	20	and	and	CCONJ
admet-2214	380	21	stratifying	stratify	VERB
admet-2214	380	22	them	they	PRON
admet-2214	380	23	based	base	VERB
admet-2214	380	24	on	on	ADP
admet-2214	380	25	their	their	PRON
admet-2214	380	26	mr	mr	PROPN
admet-2214	380	27	perfusion	perfusion	NOUN
admet-2214	380	28	score	score	NOUN
admet-2214	380	29	improves	improve	VERB
admet-2214	380	30	their	their	PRON
admet-2214	380	31	survival	survival	NOUN
admet-2214	380	32	outcomes	outcome	NOUN
admet-2214	380	33	.	.	PUNCT
admet-2214	381	1	in	in	ADP
admet-2214	381	2	addition	addition	NOUN
admet-2214	381	3	to	to	ADP
admet-2214	381	4	the	the	DET
admet-2214	381	5	standard	standard	ADJ
admet-2214	381	6	mri	mri	NOUN
admet-2214	381	7	performed	perform	VERB
admet-2214	381	8	upon	upon	SCONJ
admet-2214	381	9	diagnosis	diagnosis	NOUN
admet-2214	381	10	,	,	PUNCT
admet-2214	381	11	newly	newly	ADV
admet-2214	381	12	diagnosed	diagnose	VERB
admet-2214	381	13	dipg	dipg	NOUN
admet-2214	381	14	patients	patient	NOUN
admet-2214	381	15	will	will	AUX
admet-2214	381	16	have	have	VERB
admet-2214	381	17	an	an	DET
admet-2214	381	18	mri	mri	NOUN
admet-2214	381	19	perfusion	perfusion	NOUN
admet-2214	381	20	scan	scan	NOUN
admet-2214	381	21	,	,	PUNCT
admet-2214	381	22	which	which	PRON
admet-2214	381	23	will	will	AUX
admet-2214	381	24	allow	allow	VERB
admet-2214	381	25	them	they	PRON
admet-2214	381	26	to	to	PART
admet-2214	381	27	be	be	AUX
admet-2214	381	28	categorized	categorize	VERB
admet-2214	381	29	as	as	ADP
admet-2214	381	30	having	having	AUX
admet-2214	381	31	hyperperfused	hyperperfuse	VERB
admet-2214	381	32	or	or	CCONJ
admet-2214	381	33	hypoperfused	hypoperfused	ADJ
admet-2214	381	34	tumors	tumor	NOUN
admet-2214	381	35	.	.	PUNCT
admet-2214	382	1	weekly	weekly	ADJ
admet-2214	382	2	low	low	ADV
admet-2214	382	3	-	-	PUNCT
admet-2214	382	4	dose	dose	NOUN
admet-2214	382	5	bevacizumab	bevacizumab	NOUN
admet-2214	382	6	treatments	treatment	NOUN
admet-2214	382	7	will	will	AUX
admet-2214	382	8	be	be	AUX
admet-2214	382	9	administered	administer	VERB
admet-2214	382	10	to	to	ADP
admet-2214	382	11	the	the	DET
admet-2214	382	12	hyperperfused	hyperperfuse	VERB
admet-2214	382	13	individuals	individual	NOUN
admet-2214	382	14	along	along	ADP
admet-2214	382	15	with	with	ADP
admet-2214	382	16	traditional	traditional	ADJ
admet-2214	382	17	routine	routine	ADJ
admet-2214	382	18	radiation	radiation	NOUN
admet-2214	382	19	therapy	therapy	NOUN
admet-2214	382	20	.	.	PUNCT
admet-2214	383	1	patients	patient	NOUN
admet-2214	383	2	with	with	ADP
admet-2214	383	3	hypoperfusion	hypoperfusion	NOUN
admet-2214	383	4	will	will	AUX
admet-2214	383	5	be	be	AUX
admet-2214	383	6	administered	administer	VERB
admet-2214	383	7	ultralow	ultralow	NOUN
admet-2214	383	8	-	-	PUNCT
admet-2214	383	9	dose	dose	VERB
admet-2214	383	10	radiation	radiation	NOUN
admet-2214	383	11	fractionation	fractionation	NOUN
admet-2214	383	12	,	,	PUNCT
admet-2214	383	13	which	which	PRON
admet-2214	383	14	is	be	AUX
admet-2214	383	15	the	the	DET
admet-2214	383	16	same	same	ADJ
admet-2214	383	17	as	as	ADP
admet-2214	383	18	a	a	DET
admet-2214	383	19	biological	biological	ADJ
admet-2214	383	20	dosage	dosage	NOUN
admet-2214	383	21	of	of	ADP
admet-2214	383	22	standard	standard	PROPN
admet-2214	383	23	rt	rt	PROPN
admet-2214	383	24	.	.	PROPN
admet-2214	383	25	drug	drug	PROPN
admet-2214	383	26	:	:	PUNCT
admet-2214	383	27	bevacizumab	bevacizumab	NOUN
admet-2214	383	28	injection	injection	NOUN
admet-2214	383	29	radiation	radiation	NOUN
admet-2214	383	30	:	:	PUNCT
admet-2214	383	31	ultra	ultra	ADJ
admet-2214	383	32	-	-	ADJ
admet-2214	383	33	low	low	ADJ
admet-2214	383	34	-	-	PUNCT
admet-2214	383	35	dose	dose	NOUN
admet-2214	383	36	rt	rt	PROPN
admet-2214	383	37	nct04250064	nct04250064	NOUN
admet-2214	383	38	in	in	ADP
admet-2214	383	39	children	child	NOUN
admet-2214	383	40	with	with	ADP
admet-2214	383	41	progressing	progress	VERB
admet-2214	383	42	diffuse	diffuse	NOUN
admet-2214	383	43	midline	midline	NOUN
admet-2214	383	44	gliomas	glioma	NOUN
admet-2214	383	45	(	(	PUNCT
admet-2214	383	46	dmg	dmg	NOUN
admet-2214	383	47	)	)	PUNCT
admet-2214	383	48	,	,	PUNCT
admet-2214	383	49	this	this	DET
admet-2214	383	50	study	study	NOUN
admet-2214	383	51	intends	intend	VERB
admet-2214	383	52	to	to	PART
admet-2214	383	53	evaluate	evaluate	VERB
admet-2214	383	54	the	the	DET
admet-2214	383	55	safety	safety	NOUN
admet-2214	383	56	and	and	CCONJ
admet-2214	383	57	viability	viability	NOUN
admet-2214	383	58	of	of	ADP
admet-2214	383	59	employing	employ	VERB
admet-2214	383	60	focused	focus	VERB
admet-2214	383	61	ultrasound	ultrasound	NOUN
admet-2214	383	62	with	with	ADP
admet-2214	383	63	microbubbles	microbubble	NOUN
admet-2214	383	64	and	and	CCONJ
admet-2214	383	65	neuronavigator	neuronavigator	NOUN
admet-2214	383	66	-	-	PUNCT
admet-2214	383	67	controlled	control	VERB
admet-2214	383	68	sonication	sonication	NOUN
admet-2214	383	69	to	to	PART
admet-2214	383	70	temporarily	temporarily	ADV
admet-2214	383	71	break	break	VERB
admet-2214	383	72	the	the	DET
admet-2214	383	73	blood	blood	NOUN
admet-2214	383	74	-	-	PUNCT
admet-2214	383	75	brain	brain	NOUN
admet-2214	383	76	barrier	barrier	NOUN
admet-2214	383	77	(	(	PUNCT
admet-2214	383	78	bbb	bbb	NOUN
admet-2214	383	79	)	)	PUNCT
admet-2214	383	80	.	.	PUNCT
admet-2214	384	1	through	through	ADP
admet-2214	384	2	the	the	DET
admet-2214	384	3	use	use	NOUN
admet-2214	384	4	of	of	ADP
admet-2214	384	5	this	this	DET
admet-2214	384	6	non	non	ADJ
admet-2214	384	7	-	-	ADJ
admet-2214	384	8	invasive	invasive	ADJ
admet-2214	384	9	method	method	NOUN
admet-2214	384	10	,	,	PUNCT
admet-2214	384	11	the	the	DET
admet-2214	384	12	bbb	bbb	NOUN
admet-2214	384	13	can	can	AUX
admet-2214	384	14	be	be	AUX
admet-2214	384	15	opened	open	VERB
admet-2214	384	16	at	at	ADP
admet-2214	384	17	particular	particular	ADJ
admet-2214	384	18	points	point	NOUN
admet-2214	384	19	surrounding	surround	VERB
admet-2214	384	20	the	the	DET
admet-2214	384	21	tumor	tumor	NOUN
admet-2214	384	22	,	,	PUNCT
admet-2214	384	23	improving	improve	VERB
admet-2214	384	24	the	the	DET
admet-2214	384	25	way	way	NOUN
admet-2214	384	26	oral	oral	ADJ
admet-2214	384	27	etoposide	etoposide	NOUN
admet-2214	384	28	is	be	AUX
admet-2214	384	29	delivered	deliver	VERB
admet-2214	384	30	.	.	PUNCT
admet-2214	385	1	the	the	DET
admet-2214	385	2	prognosis	prognosis	NOUN
admet-2214	385	3	for	for	ADP
admet-2214	385	4	diffuse	diffuse	ADJ
admet-2214	385	5	midline	midline	NOUN
admet-2214	385	6	gliomas	glioma	NOUN
admet-2214	385	7	is	be	AUX
admet-2214	385	8	poor	poor	ADJ
admet-2214	385	9	,	,	PUNCT
admet-2214	385	10	especially	especially	ADV
admet-2214	385	11	for	for	ADP
admet-2214	385	12	diffuse	diffuse	ADJ
admet-2214	385	13	intrinsic	intrinsic	ADJ
admet-2214	385	14	pontine	pontine	ADJ
admet-2214	385	15	gliomas	glioma	NOUN
admet-2214	385	16	(	(	PUNCT
admet-2214	385	17	dipg	dipg	PROPN
admet-2214	385	18	)	)	PUNCT
admet-2214	385	19	.	.	PUNCT
admet-2214	386	1	this	this	DET
admet-2214	386	2	study	study	NOUN
admet-2214	386	3	investigates	investigate	VERB
admet-2214	386	4	a	a	DET
admet-2214	386	5	unique	unique	ADJ
admet-2214	386	6	strategy	strategy	NOUN
admet-2214	386	7	to	to	PART
admet-2214	386	8	maximize	maximize	VERB
admet-2214	386	9	systemic	systemic	ADJ
admet-2214	386	10	adverse	adverse	ADJ
admet-2214	386	11	effects	effect	NOUN
admet-2214	386	12	while	while	SCONJ
admet-2214	386	13	optimizing	optimize	VERB
admet-2214	386	14	drug	drug	NOUN
admet-2214	386	15	delivery	delivery	NOUN
admet-2214	386	16	and	and	CCONJ
admet-2214	386	17	treatment	treatment	NOUN
admet-2214	386	18	success	success	NOUN
admet-2214	386	19	.	.	PUNCT
admet-2214	387	1	the	the	DET
admet-2214	387	2	bbb	bbb	PROPN
admet-2214	387	3	's	's	PART
admet-2214	387	4	successful	successful	ADJ
admet-2214	387	5	opening	opening	NOUN
admet-2214	387	6	and	and	CCONJ
admet-2214	387	7	shutting	shutting	NOUN
admet-2214	387	8	will	will	AUX
admet-2214	387	9	be	be	AUX
admet-2214	387	10	confirmed	confirm	VERB
admet-2214	387	11	by	by	ADP
admet-2214	387	12	routine	routine	ADJ
admet-2214	387	13	mris	mris	PROPN
admet-2214	387	14	.	.	PUNCT
admet-2214	388	1	etoposide	etoposide	NOUN
admet-2214	388	2	;	;	PUNCT
admet-2214	388	3	oral	oral	ADJ
admet-2214	388	4	,	,	PUNCT
admet-2214	388	5	50	50	NUM
admet-2214	388	6	mg	mg	NOUN
admet-2214	388	7	,	,	PUNCT
admet-2214	388	8	focused	focused	ADJ
admet-2214	388	9	ultrasound	ultrasound	NOUN
admet-2214	388	10	therapy	therapy	NOUN
admet-2214	388	11	nct05762419	nct05762419	NOUN
admet-2214	388	12	in	in	ADP
admet-2214	388	13	this	this	DET
admet-2214	388	14	pilot	pilot	NOUN
admet-2214	388	15	trial	trial	NOUN
admet-2214	388	16	,	,	PUNCT
admet-2214	388	17	children	child	NOUN
admet-2214	388	18	with	with	ADP
admet-2214	388	19	recently	recently	ADV
admet-2214	388	20	diagnosed	diagnose	VERB
admet-2214	388	21	high	high	ADJ
admet-2214	388	22	-	-	PUNCT
admet-2214	388	23	grade	grade	NOUN
admet-2214	388	24	gliomas	glioma	NOUN
admet-2214	388	25	(	(	PUNCT
admet-2214	388	26	hgg	hgg	NOUN
admet-2214	388	27	)	)	PUNCT
admet-2214	388	28	with	with	ADP
admet-2214	388	29	trk	trk	NOUN
admet-2214	388	30	fusion	fusion	NOUN
admet-2214	388	31	are	be	AUX
admet-2214	388	32	evaluated	evaluate	VERB
admet-2214	388	33	for	for	ADP
admet-2214	388	34	disease	disease	NOUN
admet-2214	388	35	control	control	NOUN
admet-2214	388	36	and	and	CCONJ
admet-2214	388	37	survival	survival	NOUN
admet-2214	388	38	rates	rate	NOUN
admet-2214	388	39	.	.	PUNCT
admet-2214	389	1	after	after	ADP
admet-2214	389	2	two	two	NUM
admet-2214	389	3	cycles	cycle	NOUN
admet-2214	389	4	of	of	ADP
admet-2214	389	5	larotrectinib	larotrectinib	NOUN
admet-2214	389	6	monotherapy	monotherapy	NOUN
admet-2214	389	7	,	,	PUNCT
admet-2214	389	8	patients	patient	NOUN
admet-2214	389	9	receive	receive	VERB
admet-2214	389	10	maintenance	maintenance	NOUN
admet-2214	389	11	medication	medication	NOUN
admet-2214	389	12	for	for	ADP
admet-2214	389	13	responders	responder	NOUN
admet-2214	389	14	.	.	PUNCT
admet-2214	390	1	patients	patient	NOUN
admet-2214	390	2	who	who	PRON
admet-2214	390	3	show	show	VERB
admet-2214	390	4	a	a	DET
admet-2214	390	5	steady	steady	ADJ
admet-2214	390	6	course	course	NOUN
admet-2214	390	7	of	of	ADP
admet-2214	390	8	illness	illness	NOUN
admet-2214	390	9	or	or	CCONJ
admet-2214	390	10	a	a	DET
admet-2214	390	11	partial	partial	ADJ
admet-2214	390	12	response	response	NOUN
admet-2214	390	13	receive	receive	VERB
admet-2214	390	14	combination	combination	NOUN
admet-2214	390	15	therapy	therapy	NOUN
admet-2214	390	16	or	or	CCONJ
admet-2214	390	17	focused	focused	ADJ
admet-2214	390	18	radiotherapy	radiotherapy	NOUN
admet-2214	390	19	.	.	PUNCT
admet-2214	391	1	pre	pre	ADJ
admet-2214	391	2	-	-	ADJ
admet-2214	391	3	surgery	surgery	ADJ
admet-2214	391	4	effects	effect	NOUN
admet-2214	391	5	of	of	ADP
admet-2214	391	6	larotrectinib	larotrectinib	NOUN
admet-2214	391	7	are	be	AUX
admet-2214	391	8	investigated	investigate	VERB
admet-2214	391	9	in	in	ADP
admet-2214	391	10	a	a	DET
admet-2214	391	11	surgical	surgical	ADJ
admet-2214	391	12	cohort	cohort	NOUN
admet-2214	391	13	.	.	PUNCT
admet-2214	392	1	in	in	ADP
admet-2214	392	2	addition	addition	NOUN
admet-2214	392	3	to	to	ADP
admet-2214	392	4	evaluating	evaluate	VERB
admet-2214	392	5	the	the	DET
admet-2214	392	6	safety	safety	NOUN
admet-2214	392	7	of	of	ADP
admet-2214	392	8	larotrectinib	larotrectinib	NOUN
admet-2214	392	9	monotherapy	monotherapy	NOUN
admet-2214	392	10	,	,	PUNCT
admet-2214	392	11	combination	combination	NOUN
admet-2214	392	12	therapy	therapy	NOUN
admet-2214	392	13	,	,	PUNCT
admet-2214	392	14	and	and	CCONJ
admet-2214	392	15	radiation	radiation	NOUN
admet-2214	392	16	therapy	therapy	NOUN
admet-2214	392	17	,	,	PUNCT
admet-2214	392	18	the	the	DET
admet-2214	392	19	trial	trial	NOUN
admet-2214	392	20	intends	intend	VERB
admet-2214	392	21	to	to	PART
admet-2214	392	22	enroll	enroll	VERB
admet-2214	392	23	15	15	NUM
admet-2214	392	24	patients	patient	NOUN
admet-2214	392	25	for	for	ADP
admet-2214	392	26	disease	disease	NOUN
admet-2214	392	27	control	control	NOUN
admet-2214	392	28	and	and	CCONJ
admet-2214	392	29	safety	safety	NOUN
admet-2214	392	30	assessment	assessment	NOUN
admet-2214	392	31	.	.	PUNCT
admet-2214	393	1	larotrectinib	larotrectinib	NOUN
admet-2214	393	2	nct04655404	nct04655404	NOUN
admet-2214	393	3	admet	admet	PROPN
admet-2214	393	4	&	&	CCONJ
admet-2214	393	5	dmpk	dmpk	PROPN
admet-2214	393	6	12(3	12(3	PROPN
admet-2214	393	7	)	)	PUNCT
admet-2214	393	8	(	(	PUNCT
admet-2214	393	9	2024	2024	NUM
admet-2214	393	10	)	)	PUNCT
admet-2214	393	11	403	403	NUM
admet-2214	393	12	-	-	SYM
admet-2214	393	13	429	429	NUM
admet-2214	393	14	addressing	address	VERB
admet-2214	393	15	barriers	barrier	NOUN
admet-2214	393	16	in	in	ADP
admet-2214	393	17	diffuse	diffuse	ADJ
admet-2214	393	18	intrinsic	intrinsic	ADJ
admet-2214	393	19	pontine	pontine	ADJ
admet-2214	393	20	glioma	glioma	NOUN
admet-2214	393	21	doi	doi	NOUN
admet-2214	393	22	:	:	PUNCT
admet-2214	393	23	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	X
admet-2214	393	24	421	421	NUM
admet-2214	393	25	description	description	NOUN
admet-2214	393	26	drug	drug	NOUN
admet-2214	393	27	clinicaltrials.gov	clinicaltrials.gov	PUNCT
admet-2214	393	28	identifier	identifier	NOUN
admet-2214	393	29	in	in	ADP
admet-2214	393	30	children	child	NOUN
admet-2214	393	31	and	and	CCONJ
admet-2214	393	32	adolescents	adolescent	NOUN
admet-2214	393	33	with	with	ADP
admet-2214	393	34	glioblastoma	glioblastoma	NOUN
admet-2214	393	35	,	,	PUNCT
admet-2214	393	36	diffuse	diffuse	ADJ
admet-2214	393	37	intrinsic	intrinsic	ADJ
admet-2214	393	38	pontine	pontine	ADJ
admet-2214	393	39	glioma	glioma	NOUN
admet-2214	393	40	(	(	PUNCT
admet-2214	393	41	dipg	dipg	PROPN
admet-2214	393	42	)	)	PUNCT
admet-2214	393	43	,	,	PUNCT
admet-2214	393	44	anaplastic	anaplastic	ADJ
admet-2214	393	45	astrocytoma	astrocytoma	NOUN
admet-2214	393	46	,	,	PUNCT
admet-2214	393	47	and	and	CCONJ
admet-2214	393	48	gliomatosis	gliomatosis	NOUN
admet-2214	393	49	cerebri	cerebri	NOUN
admet-2214	393	50	,	,	PUNCT
admet-2214	393	51	the	the	DET
admet-2214	393	52	hit	hit	NOUN
admet-2214	393	53	-	-	PUNCT
admet-2214	393	54	hgg-2013	hgg-2013	NOUN
admet-2214	393	55	study	study	NOUN
admet-2214	393	56	investigates	investigate	VERB
admet-2214	393	57	the	the	DET
admet-2214	393	58	possibility	possibility	NOUN
admet-2214	393	59	of	of	ADP
admet-2214	393	60	valproic	valproic	ADJ
admet-2214	393	61	acid	acid	NOUN
admet-2214	393	62	,	,	PUNCT
admet-2214	393	63	a	a	DET
admet-2214	393	64	histone	histone	NOUN
admet-2214	393	65	deacetylase	deacetylase	NOUN
admet-2214	393	66	inhibitor	inhibitor	NOUN
admet-2214	393	67	,	,	PUNCT
admet-2214	393	68	augmenting	augment	VERB
admet-2214	393	69	the	the	DET
admet-2214	393	70	effects	effect	NOUN
admet-2214	393	71	of	of	ADP
admet-2214	393	72	radiotherapy	radiotherapy	NOUN
admet-2214	393	73	and	and	CCONJ
admet-2214	393	74	chemotherapy	chemotherapy	NOUN
admet-2214	393	75	(	(	PUNCT
admet-2214	393	76	temozolomide	temozolomide	NOUN
admet-2214	393	77	)	)	PUNCT
admet-2214	393	78	.	.	PUNCT
admet-2214	394	1	it	it	PRON
admet-2214	394	2	attempts	attempt	VERB
admet-2214	394	3	to	to	PART
admet-2214	394	4	compare	compare	VERB
admet-2214	394	5	the	the	DET
admet-2214	394	6	results	result	NOUN
admet-2214	394	7	with	with	ADP
admet-2214	394	8	the	the	DET
admet-2214	394	9	hit	hit	NOUN
admet-2214	394	10	-	-	PUNCT
admet-2214	394	11	hgg-2007	hgg-2007	NOUN
admet-2214	394	12	study	study	NOUN
admet-2214	394	13	in	in	ADP
admet-2214	394	14	order	order	NOUN
admet-2214	394	15	to	to	PART
admet-2214	394	16	assess	assess	VERB
admet-2214	394	17	the	the	DET
admet-2214	394	18	safety	safety	NOUN
admet-2214	394	19	and	and	CCONJ
admet-2214	394	20	therapeutic	therapeutic	ADJ
admet-2214	394	21	efficacy	efficacy	NOUN
admet-2214	394	22	of	of	ADP
admet-2214	394	23	valproic	valproic	ADJ
admet-2214	394	24	acid	acid	NOUN
admet-2214	394	25	in	in	ADP
admet-2214	394	26	treating	treat	VERB
admet-2214	394	27	these	these	DET
admet-2214	394	28	aggressive	aggressive	ADJ
admet-2214	394	29	brain	brain	NOUN
admet-2214	394	30	tumors	tumor	NOUN
admet-2214	394	31	.	.	PUNCT
admet-2214	395	1	originally	originally	ADV
admet-2214	395	2	,	,	PUNCT
admet-2214	395	3	an	an	DET
admet-2214	395	4	autophagy	autophagy	ADJ
admet-2214	395	5	inhibitor	inhibitor	NOUN
admet-2214	395	6	(	(	PUNCT
admet-2214	395	7	chloroquine	chloroquine	NOUN
admet-2214	395	8	)	)	PUNCT
admet-2214	395	9	was	be	AUX
admet-2214	395	10	included	include	VERB
admet-2214	395	11	in	in	ADP
admet-2214	395	12	the	the	DET
admet-2214	395	13	trial	trial	NOUN
admet-2214	395	14	,	,	PUNCT
admet-2214	395	15	but	but	CCONJ
admet-2214	395	16	it	it	PRON
admet-2214	395	17	was	be	AUX
admet-2214	395	18	later	later	ADV
admet-2214	395	19	canceled	cancel	VERB
admet-2214	395	20	since	since	SCONJ
admet-2214	395	21	resochin	resochin	ADJ
admet-2214	395	22	junior	junior	NOUN
admet-2214	395	23	was	be	AUX
admet-2214	395	24	not	not	PART
admet-2214	395	25	available	available	ADJ
admet-2214	395	26	.	.	PUNCT
admet-2214	396	1	temozolomide	temozolomide	NOUN
admet-2214	396	2	+	+	CCONJ
admet-2214	396	3	valproic	valproic	ADJ
admet-2214	396	4	acid	acid	NOUN
admet-2214	396	5	nct03243461	nct03243461	ADJ
admet-2214	396	6	in	in	ADP
admet-2214	396	7	this	this	DET
admet-2214	396	8	phase	phase	NOUN
admet-2214	396	9	i	i	PRON
admet-2214	396	10	trial	trial	NOUN
admet-2214	396	11	,	,	PUNCT
admet-2214	396	12	patients	patient	NOUN
admet-2214	396	13	with	with	ADP
admet-2214	396	14	primary	primary	ADJ
admet-2214	396	15	central	central	ADJ
admet-2214	396	16	nervous	nervous	ADJ
admet-2214	396	17	system	system	NOUN
admet-2214	396	18	(	(	PUNCT
admet-2214	396	19	cns	cns	NOUN
admet-2214	396	20	)	)	PUNCT
admet-2214	396	21	cancers	cancer	NOUN
admet-2214	396	22	that	that	PRON
admet-2214	396	23	have	have	AUX
admet-2214	396	24	returned	return	VERB
admet-2214	396	25	(	(	PUNCT
admet-2214	396	26	recurrent	recurrent	NOUN
admet-2214	396	27	)	)	PUNCT
admet-2214	396	28	or	or	CCONJ
admet-2214	396	29	are	be	AUX
admet-2214	396	30	resistant	resistant	ADJ
admet-2214	396	31	to	to	ADP
admet-2214	396	32	treatment	treatment	NOUN
admet-2214	396	33	(	(	PUNCT
admet-2214	396	34	refractory	refractory	NOUN
admet-2214	396	35	)	)	PUNCT
admet-2214	396	36	are	be	AUX
admet-2214	396	37	being	be	AUX
admet-2214	396	38	treated	treat	VERB
admet-2214	396	39	for	for	ADP
admet-2214	396	40	the	the	DET
admet-2214	396	41	adverse	adverse	ADJ
admet-2214	396	42	effects	effect	NOUN
admet-2214	396	43	and	and	CCONJ
admet-2214	396	44	optimal	optimal	ADJ
admet-2214	396	45	dose	dose	NOUN
admet-2214	396	46	of	of	ADP
admet-2214	396	47	volitinib	volitinib	NOUN
admet-2214	396	48	.	.	PUNCT
admet-2214	397	1	by	by	ADP
admet-2214	397	2	inhibiting	inhibit	VERB
admet-2214	397	3	some	some	PRON
admet-2214	397	4	of	of	ADP
admet-2214	397	5	the	the	DET
admet-2214	397	6	enzymes	enzyme	NOUN
admet-2214	397	7	required	require	VERB
admet-2214	397	8	for	for	ADP
admet-2214	397	9	cell	cell	NOUN
admet-2214	397	10	growth	growth	NOUN
admet-2214	397	11	,	,	PUNCT
admet-2214	397	12	volitinib	volitinib	NOUN
admet-2214	397	13	may	may	AUX
admet-2214	397	14	be	be	AUX
admet-2214	397	15	able	able	ADJ
admet-2214	397	16	to	to	PART
admet-2214	397	17	stop	stop	VERB
admet-2214	397	18	the	the	DET
admet-2214	397	19	proliferation	proliferation	NOUN
admet-2214	397	20	of	of	ADP
admet-2214	397	21	tumor	tumor	NOUN
admet-2214	397	22	cells	cell	NOUN
admet-2214	397	23	.	.	PUNCT
admet-2214	398	1	savolitinib	savolitinib	PROPN
admet-2214	398	2	nct03598244	nct03598244	VERB
admet-2214	398	3	for	for	ADP
admet-2214	398	4	pediatric	pediatric	ADJ
admet-2214	398	5	patients	patient	NOUN
admet-2214	398	6	(	(	PUNCT
admet-2214	398	7	ages	age	NOUN
admet-2214	398	8	3	3	NUM
admet-2214	398	9	to	to	PART
admet-2214	398	10	21	21	NUM
admet-2214	398	11	)	)	PUNCT
admet-2214	398	12	with	with	ADP
admet-2214	398	13	progressing	progress	VERB
admet-2214	398	14	brain	brain	NOUN
admet-2214	398	15	cancer	cancer	NOUN
admet-2214	398	16	or	or	CCONJ
admet-2214	398	17	newly	newly	ADV
admet-2214	398	18	diagnosed	diagnose	VERB
admet-2214	398	19	diffuse	diffuse	NOUN
admet-2214	398	20	intrinsic	intrinsic	ADJ
admet-2214	398	21	pontine	pontine	ADJ
admet-2214	398	22	glioma	glioma	NOUN
admet-2214	398	23	(	(	PUNCT
admet-2214	398	24	dipg	dipg	PROPN
admet-2214	398	25	)	)	PUNCT
admet-2214	398	26	,	,	PUNCT
admet-2214	398	27	indoximod	indoximod	NOUN
admet-2214	398	28	-	-	PUNCT
admet-2214	398	29	based	base	VERB
admet-2214	398	30	chemo	chemo	NOUN
admet-2214	398	31	-	-	PUNCT
admet-2214	398	32	radio	radio	NOUN
admet-2214	398	33	-	-	PUNCT
admet-2214	398	34	immunotherapy	immunotherapy	NOUN
admet-2214	398	35	is	be	AUX
admet-2214	398	36	being	be	AUX
admet-2214	398	37	investigated	investigate	VERB
admet-2214	398	38	in	in	ADP
admet-2214	398	39	the	the	DET
admet-2214	398	40	gcc1949	gcc1949	NOUN
admet-2214	398	41	project	project	NOUN
admet-2214	398	42	,	,	PUNCT
admet-2214	398	43	an	an	DET
admet-2214	398	44	open	open	ADJ
admet-2214	398	45	-	-	PUNCT
admet-2214	398	46	label	label	NOUN
admet-2214	398	47	phase	phase	NOUN
admet-2214	398	48	2	2	NUM
admet-2214	398	49	trial	trial	NOUN
admet-2214	398	50	funded	fund	VERB
admet-2214	398	51	by	by	ADP
admet-2214	398	52	the	the	DET
admet-2214	398	53	nci	nci	PROPN
admet-2214	398	54	.	.	PUNCT
admet-2214	399	1	when	when	SCONJ
admet-2214	399	2	paired	pair	VERB
admet-2214	399	3	with	with	ADP
admet-2214	399	4	conventional	conventional	ADJ
admet-2214	399	5	therapy	therapy	NOUN
admet-2214	399	6	,	,	PUNCT
admet-2214	399	7	inhibiting	inhibit	VERB
admet-2214	399	8	the	the	DET
admet-2214	399	9	ido	ido	NOUN
admet-2214	399	10	pathway	pathway	NOUN
admet-2214	399	11	—	—	PUNCT
admet-2214	399	12	which	which	PRON
admet-2214	399	13	is	be	AUX
admet-2214	399	14	essential	essential	ADJ
admet-2214	399	15	for	for	ADP
admet-2214	399	16	immune	immune	ADJ
admet-2214	399	17	regulation	regulation	NOUN
admet-2214	399	18	—	—	PUNCT
admet-2214	399	19	is	be	AUX
admet-2214	399	20	thought	think	VERB
admet-2214	399	21	to	to	PART
admet-2214	399	22	improve	improve	VERB
admet-2214	399	23	antitumor	antitumor	PROPN
admet-2214	399	24	immune	immune	ADJ
admet-2214	399	25	responses	response	NOUN
admet-2214	399	26	and	and	CCONJ
admet-2214	399	27	may	may	AUX
admet-2214	399	28	lead	lead	VERB
admet-2214	399	29	to	to	ADP
admet-2214	399	30	better	well	ADJ
admet-2214	399	31	results	result	NOUN
admet-2214	399	32	.	.	PUNCT
admet-2214	400	1	up	up	ADP
admet-2214	400	2	to	to	PART
admet-2214	400	3	140	140	NUM
admet-2214	400	4	patients	patient	NOUN
admet-2214	400	5	may	may	AUX
admet-2214	400	6	be	be	AUX
admet-2214	400	7	included	include	VERB
admet-2214	400	8	in	in	ADP
admet-2214	400	9	the	the	DET
admet-2214	400	10	johnson	johnson	PROPN
admet-2214	400	11	and	and	CCONJ
admet-2214	400	12	munn	munn	PROPN
admet-2214	400	13	-	-	PUNCT
admet-2214	400	14	led	lead	VERB
admet-2214	400	15	study	study	NOUN
admet-2214	400	16	,	,	PUNCT
admet-2214	400	17	which	which	PRON
admet-2214	400	18	is	be	AUX
admet-2214	400	19	categorized	categorize	VERB
admet-2214	400	20	according	accord	VERB
admet-2214	400	21	to	to	ADP
admet-2214	400	22	the	the	DET
admet-2214	400	23	patients	patient	NOUN
admet-2214	400	24	'	'	PART
admet-2214	400	25	receipt	receipt	NOUN
admet-2214	400	26	of	of	ADP
admet-2214	400	27	radiation	radiation	NOUN
admet-2214	400	28	therapy	therapy	NOUN
admet-2214	400	29	and	and	CCONJ
admet-2214	400	30	focuses	focus	VERB
admet-2214	400	31	on	on	ADP
admet-2214	400	32	glioblastoma	glioblastoma	NOUN
admet-2214	400	33	,	,	PUNCT
admet-2214	400	34	medulloblastoma	medulloblastoma	ADJ
admet-2214	400	35	,	,	PUNCT
admet-2214	400	36	and	and	CCONJ
admet-2214	400	37	ependymoma	ependymoma	NOUN
admet-2214	400	38	.	.	PUNCT
admet-2214	401	1	irano	irano	NOUN
admet-2214	401	2	standards	standard	NOUN
admet-2214	401	3	will	will	AUX
admet-2214	401	4	evaluate	evaluate	VERB
admet-2214	401	5	results	result	NOUN
admet-2214	401	6	.	.	PUNCT
admet-2214	402	1	indoximod	indoximod	PROPN
admet-2214	402	2	,	,	PUNCT
admet-2214	402	3	temozolamide	temozolamide	ADJ
admet-2214	402	4	,	,	PUNCT
admet-2214	402	5	cyclophosmphamide	cyclophosmphamide	NOUN
admet-2214	402	6	,	,	PUNCT
admet-2214	402	7	etoposide	etoposide	NOUN
admet-2214	402	8	,	,	PUNCT
admet-2214	402	9	lomustine	lomustine	ADJ
admet-2214	402	10	nct04049669	nct04049669	NOUN
admet-2214	402	11	in	in	ADP
admet-2214	402	12	this	this	DET
admet-2214	402	13	phase	phase	NOUN
admet-2214	402	14	i	i	PROPN
admet-2214	402	15	/	/	SYM
admet-2214	402	16	ii	ii	PROPN
admet-2214	402	17	trial	trial	NOUN
admet-2214	402	18	,	,	PUNCT
admet-2214	402	19	mebendazole	mebendazole	NOUN
admet-2214	402	20	is	be	AUX
admet-2214	402	21	being	be	AUX
admet-2214	402	22	investigated	investigate	VERB
admet-2214	402	23	in	in	ADP
admet-2214	402	24	conjunction	conjunction	NOUN
admet-2214	402	25	with	with	ADP
admet-2214	402	26	conventional	conventional	ADJ
admet-2214	402	27	treatments	treatment	NOUN
admet-2214	402	28	for	for	ADP
admet-2214	402	29	juvenile	juvenile	ADJ
admet-2214	402	30	gliomas	glioma	NOUN
admet-2214	402	31	.	.	PUNCT
admet-2214	403	1	mebendazole	mebendazole	NOUN
admet-2214	403	2	is	be	AUX
admet-2214	403	3	prescribed	prescribe	VERB
admet-2214	403	4	with	with	ADP
admet-2214	403	5	vincristine	vincristine	NOUN
admet-2214	403	6	,	,	PUNCT
admet-2214	403	7	carboplatin	carboplatin	NOUN
admet-2214	403	8	,	,	PUNCT
admet-2214	403	9	and	and	CCONJ
admet-2214	403	10	temozolomide	temozolomide	NOUN
admet-2214	403	11	for	for	ADP
admet-2214	403	12	patients	patient	NOUN
admet-2214	403	13	with	with	ADP
admet-2214	403	14	low	low	ADJ
admet-2214	403	15	-	-	PUNCT
admet-2214	403	16	grade	grade	NOUN
admet-2214	403	17	gliomas	glioma	NOUN
admet-2214	403	18	,	,	PUNCT
admet-2214	403	19	and	and	CCONJ
admet-2214	403	20	with	with	ADP
admet-2214	403	21	bevacizumab	bevacizumab	NOUN
admet-2214	403	22	and	and	CCONJ
admet-2214	403	23	irinotecan	irinotecan	NOUN
admet-2214	403	24	for	for	ADP
admet-2214	403	25	patients	patient	NOUN
admet-2214	403	26	with	with	ADP
admet-2214	403	27	high	high	ADJ
admet-2214	403	28	-	-	PUNCT
admet-2214	403	29	grade	grade	NOUN
admet-2214	403	30	/	/	SYM
admet-2214	403	31	diffuse	diffuse	NOUN
admet-2214	403	32	intrinsic	intrinsic	ADJ
admet-2214	403	33	pontine	pontine	ADJ
admet-2214	403	34	gliomas	glioma	NOUN
admet-2214	403	35	.	.	PUNCT
admet-2214	404	1	gross	gross	ADJ
admet-2214	404	2	complete	complete	ADJ
admet-2214	404	3	resection	resection	NOUN
admet-2214	404	4	without	without	ADP
admet-2214	404	5	significant	significant	ADJ
admet-2214	404	6	neurologic	neurologic	ADJ
admet-2214	404	7	deficit	deficit	NOUN
admet-2214	404	8	is	be	AUX
admet-2214	404	9	the	the	DET
admet-2214	404	10	goal	goal	NOUN
admet-2214	404	11	of	of	ADP
admet-2214	404	12	surgical	surgical	ADJ
admet-2214	404	13	resection	resection	NOUN
admet-2214	404	14	.	.	PUNCT
admet-2214	405	1	doses	dose	NOUN
admet-2214	405	2	of	of	ADP
admet-2214	405	3	metronidazole	metronidazole	NOUN
admet-2214	405	4	increase	increase	NOUN
admet-2214	405	5	from	from	ADP
admet-2214	405	6	50	50	NUM
admet-2214	405	7	to	to	ADP
admet-2214	405	8	200	200	NUM
admet-2214	405	9	mg	mg	NOUN
admet-2214	405	10	/	/	SYM
admet-2214	405	11	kg	kg	NOUN
admet-2214	405	12	per	per	ADP
admet-2214	405	13	day	day	NOUN
admet-2214	405	14	.	.	PUNCT
admet-2214	406	1	a	a	DET
admet-2214	406	2	"	"	PUNCT
admet-2214	406	3	3	3	NUM
admet-2214	406	4	+	+	NOUN
admet-2214	406	5	3	3	NUM
admet-2214	406	6	"	"	PUNCT
admet-2214	406	7	design	design	NOUN
admet-2214	406	8	is	be	AUX
admet-2214	406	9	used	use	VERB
admet-2214	406	10	to	to	PART
admet-2214	406	11	monitor	monitor	VERB
admet-2214	406	12	safety	safety	NOUN
admet-2214	406	13	.	.	PUNCT
admet-2214	407	1	the	the	DET
admet-2214	407	2	most	most	ADV
admet-2214	407	3	tolerable	tolerable	ADJ
admet-2214	407	4	dose	dose	NOUN
admet-2214	407	5	is	be	AUX
admet-2214	407	6	established	establish	VERB
admet-2214	407	7	,	,	PUNCT
admet-2214	407	8	effectiveness	effectiveness	NOUN
admet-2214	407	9	is	be	AUX
admet-2214	407	10	assessed	assess	VERB
admet-2214	407	11	,	,	PUNCT
admet-2214	407	12	and	and	CCONJ
admet-2214	407	13	patients	patient	NOUN
admet-2214	407	14	proceed	proceed	VERB
admet-2214	407	15	with	with	ADP
admet-2214	407	16	maintenance	maintenance	NOUN
admet-2214	407	17	treatment	treatment	NOUN
admet-2214	407	18	while	while	SCONJ
admet-2214	407	19	having	have	VERB
admet-2214	407	20	their	their	PRON
admet-2214	407	21	overall	overall	ADJ
admet-2214	407	22	survival	survival	NOUN
admet-2214	407	23	and	and	CCONJ
admet-2214	407	24	lack	lack	NOUN
admet-2214	407	25	of	of	ADP
admet-2214	407	26	progression	progression	NOUN
admet-2214	407	27	observed	observe	VERB
admet-2214	407	28	by	by	ADP
admet-2214	407	29	magnetic	magnetic	ADJ
admet-2214	407	30	resonance	resonance	NOUN
admet-2214	407	31	imaging	imaging	NOUN
admet-2214	407	32	(	(	PUNCT
admet-2214	407	33	mri	mri	NOUN
admet-2214	407	34	)	)	PUNCT
admet-2214	407	35	.	.	PUNCT
admet-2214	408	1	mebendazole	mebendazole	PROPN
admet-2214	408	2	vincristine	vincristine	PROPN
admet-2214	408	3	carboplatin	carboplatin	PROPN
admet-2214	408	4	temozolomide	temozolomide	PROPN
admet-2214	408	5	bevacizumab	bevacizumab	PROPN
admet-2214	408	6	irinotecan	irinotecan	ADJ
admet-2214	408	7	nct01837862	nct01837862	NOUN
admet-2214	408	8	conclusion	conclusion	VERB
admet-2214	408	9	patients	patient	NOUN
admet-2214	408	10	with	with	ADP
admet-2214	408	11	dipg	dipg	PROPN
admet-2214	408	12	still	still	ADV
admet-2214	408	13	have	have	VERB
admet-2214	408	14	a	a	DET
admet-2214	408	15	bad	bad	ADJ
admet-2214	408	16	prognosis	prognosis	NOUN
admet-2214	408	17	.	.	PUNCT
admet-2214	409	1	contrary	contrary	ADJ
admet-2214	409	2	to	to	ADP
admet-2214	409	3	other	other	ADJ
admet-2214	409	4	malignant	malignant	ADJ
admet-2214	409	5	gliomas	glioma	NOUN
admet-2214	409	6	for	for	ADP
admet-2214	409	7	which	which	PRON
admet-2214	409	8	active	active	ADJ
admet-2214	409	9	chemotherapeutic	chemotherapeutic	ADJ
admet-2214	409	10	medicines	medicine	NOUN
admet-2214	409	11	have	have	AUX
admet-2214	409	12	been	be	AUX
admet-2214	409	13	identified	identify	VERB
admet-2214	409	14	,	,	PUNCT
admet-2214	409	15	the	the	DET
admet-2214	409	16	only	only	ADJ
admet-2214	409	17	established	establish	VERB
admet-2214	409	18	treatment	treatment	NOUN
admet-2214	409	19	for	for	ADP
admet-2214	409	20	this	this	DET
admet-2214	409	21	illness	illness	NOUN
admet-2214	409	22	is	be	AUX
admet-2214	409	23	chemotherapy	chemotherapy	NOUN
admet-2214	409	24	administered	administer	VERB
admet-2214	409	25	in	in	ADP
admet-2214	409	26	conjunction	conjunction	NOUN
admet-2214	409	27	with	with	ADP
admet-2214	409	28	radiation	radiation	NOUN
admet-2214	409	29	.	.	PUNCT
admet-2214	410	1	as	as	ADP
admet-2214	410	2	a	a	DET
admet-2214	410	3	result	result	NOUN
admet-2214	410	4	of	of	ADP
admet-2214	410	5	the	the	DET
admet-2214	410	6	clinical	clinical	ADJ
admet-2214	410	7	manifestations	manifestation	NOUN
admet-2214	410	8	,	,	PUNCT
admet-2214	410	9	molecular	molecular	ADJ
admet-2214	410	10	characterization	characterization	NOUN
admet-2214	410	11	,	,	PUNCT
admet-2214	410	12	formulation	formulation	NOUN
admet-2214	410	13	improvements	improvement	NOUN
admet-2214	410	14	,	,	PUNCT
admet-2214	410	15	and	and	CCONJ
admet-2214	410	16	drug	drug	NOUN
admet-2214	410	17	delivery	delivery	NOUN
admet-2214	410	18	system	system	NOUN
admet-2214	410	19	discussions	discussion	NOUN
admet-2214	410	20	in	in	ADP
admet-2214	410	21	this	this	DET
admet-2214	410	22	article	article	NOUN
admet-2214	410	23	,	,	PUNCT
admet-2214	410	24	it	it	PRON
admet-2214	410	25	can	can	AUX
admet-2214	410	26	be	be	AUX
admet-2214	410	27	concluded	conclude	VERB
admet-2214	410	28	that	that	SCONJ
admet-2214	410	29	the	the	DET
admet-2214	410	30	use	use	NOUN
admet-2214	410	31	of	of	ADP
admet-2214	410	32	nanoparticulate	nanoparticulate	ADJ
admet-2214	410	33	drug	drug	NOUN
admet-2214	410	34	delivery	delivery	NOUN
admet-2214	410	35	systems	system	NOUN
admet-2214	410	36	is	be	AUX
admet-2214	410	37	a	a	DET
admet-2214	410	38	possible	possible	ADJ
admet-2214	410	39	tactics	tactic	NOUN
admet-2214	410	40	for	for	ADP
admet-2214	410	41	the	the	DET
admet-2214	410	42	treatment	treatment	NOUN
admet-2214	410	43	of	of	ADP
admet-2214	410	44	dipg	dipg	NOUN
admet-2214	410	45	.	.	PUNCT
admet-2214	411	1	the	the	DET
admet-2214	411	2	lipid	lipid	NOUN
admet-2214	411	3	-	-	PUNCT
admet-2214	411	4	based	base	VERB
admet-2214	411	5	nanoparticulate	nanoparticulate	ADJ
admet-2214	411	6	drug	drug	NOUN
admet-2214	411	7	delivery	delivery	NOUN
admet-2214	411	8	system	system	NOUN
admet-2214	411	9	for	for	ADP
admet-2214	411	10	brain	brain	NOUN
admet-2214	411	11	cancer	cancer	NOUN
admet-2214	411	12	demonstrates	demonstrate	VERB
admet-2214	411	13	remarkable	remarkable	ADJ
admet-2214	411	14	efficacy	efficacy	NOUN
admet-2214	411	15	owing	owe	VERB
admet-2214	411	16	to	to	ADP
admet-2214	411	17	its	its	PRON
admet-2214	411	18	unique	unique	ADJ
admet-2214	411	19	capability	capability	NOUN
admet-2214	411	20	to	to	PART
admet-2214	411	21	traverse	traverse	VERB
admet-2214	411	22	the	the	DET
admet-2214	411	23	blood	blood	NOUN
admet-2214	411	24	-	-	PUNCT
admet-2214	411	25	brain	brain	NOUN
admet-2214	411	26	barrier	barrier	NOUN
admet-2214	411	27	,	,	PUNCT
admet-2214	411	28	thereby	thereby	ADV
admet-2214	411	29	facilitating	facilitate	VERB
admet-2214	411	30	precise	precise	ADJ
admet-2214	411	31	and	and	CCONJ
admet-2214	411	32	targeted	target	VERB
admet-2214	411	33	drug	drug	NOUN
admet-2214	411	34	delivery	delivery	NOUN
admet-2214	411	35	.	.	PUNCT
admet-2214	412	1	the	the	DET
admet-2214	412	2	utilization	utilization	NOUN
admet-2214	412	3	of	of	ADP
admet-2214	412	4	nanoparticles	nanoparticle	NOUN
admet-2214	412	5	presents	present	VERB
admet-2214	412	6	a	a	DET
admet-2214	412	7	promising	promising	ADJ
admet-2214	412	8	avenue	avenue	NOUN
admet-2214	412	9	for	for	ADP
admet-2214	412	10	achieving	achieve	VERB
admet-2214	412	11	controlled	control	VERB
admet-2214	412	12	release	release	NOUN
admet-2214	412	13	kinetics	kinetic	NOUN
admet-2214	412	14	,	,	PUNCT
admet-2214	412	15	thereby	thereby	ADV
admet-2214	412	16	mitigating	mitigate	VERB
admet-2214	412	17	potential	potential	ADJ
admet-2214	412	18	side	side	NOUN
admet-2214	412	19	effects	effect	NOUN
admet-2214	412	20	and	and	CCONJ
admet-2214	412	21	augmenting	augment	VERB
admet-2214	412	22	the	the	DET
admet-2214	412	23	therapeutic	therapeutic	ADJ
admet-2214	412	24	efficacy	efficacy	NOUN
admet-2214	412	25	of	of	ADP
admet-2214	412	26	various	various	ADJ
admet-2214	412	27	treatments	treatment	NOUN
admet-2214	412	28	.	.	PUNCT
admet-2214	413	1	the	the	DET
admet-2214	413	2	superiority	superiority	NOUN
admet-2214	413	3	of	of	ADP
admet-2214	413	4	these	these	DET
admet-2214	413	5	agents	agent	NOUN
admet-2214	413	6	is	be	AUX
admet-2214	413	7	underscored	underscore	VERB
admet-2214	413	8	by	by	ADP
admet-2214	413	9	their	their	PRON
admet-2214	413	10	exceptional	exceptional	ADJ
admet-2214	413	11	biocompatibility	biocompatibility	NOUN
admet-2214	413	12	and	and	CCONJ
admet-2214	413	13	safety	safety	NOUN
admet-2214	413	14	profile	profile	NOUN
admet-2214	413	15	,	,	PUNCT
admet-2214	413	16	as	as	ADV
admet-2214	413	17	well	well	ADV
admet-2214	413	18	as	as	ADP
admet-2214	413	19	their	their	PRON
admet-2214	413	20	remarkable	remarkable	ADJ
admet-2214	413	21	specificity	specificity	NOUN
admet-2214	413	22	for	for	ADP
admet-2214	413	23	targeting	target	VERB
admet-2214	413	24	cancer	cancer	NOUN
admet-2214	413	25	cells	cell	NOUN
admet-2214	413	26	.	.	PUNCT
admet-2214	414	1	the	the	DET
admet-2214	414	2	promising	promising	ADJ
admet-2214	414	3	strategy	strategy	NOUN
admet-2214	414	4	of	of	ADP
admet-2214	414	5	utilizing	utilize	VERB
admet-2214	414	6	lipid	lipid	NOUN
admet-2214	414	7	-	-	PUNCT
admet-2214	414	8	based	base	VERB
admet-2214	414	9	nanoparticulate	nanoparticulate	ADJ
admet-2214	414	10	drug	drug	NOUN
admet-2214	414	11	delivery	delivery	NOUN
admet-2214	414	12	for	for	ADP
admet-2214	414	13	brain	brain	NOUN
admet-2214	414	14	cancer	cancer	NOUN
admet-2214	414	15	treatment	treatment	NOUN
admet-2214	414	16	is	be	AUX
admet-2214	414	17	supported	support	VERB
admet-2214	414	18	by	by	ADP
admet-2214	414	19	robust	robust	ADJ
admet-2214	414	20	clinical	clinical	ADJ
admet-2214	414	21	evidence	evidence	NOUN
admet-2214	414	22	,	,	PUNCT
admet-2214	414	23	demonstrating	demonstrate	VERB
admet-2214	414	24	improved	improved	ADJ
admet-2214	414	25	outcomes	outcome	NOUN
admet-2214	414	26	.	.	PUNCT
admet-2214	415	1	the	the	DET
admet-2214	415	2	scalability	scalability	NOUN
admet-2214	415	3	and	and	CCONJ
admet-2214	415	4	cost	cost	NOUN
admet-2214	415	5	-	-	PUNCT
admet-2214	415	6	effectiveness	effectiveness	NOUN
admet-2214	415	7	of	of	ADP
admet-2214	415	8	this	this	DET
admet-2214	415	9	approach	approach	NOUN
admet-2214	415	10	further	far	ADV
admet-2214	415	11	strengthen	strengthen	VERB
admet-2214	415	12	its	its	PRON
admet-2214	415	13	potential	potential	NOUN
admet-2214	415	14	in	in	ADP
admet-2214	415	15	the	the	DET
admet-2214	415	16	field	field	NOUN
admet-2214	415	17	.	.	PUNCT
admet-2214	416	1	acknowledgements	acknowledgement	NOUN
admet-2214	416	2	:	:	PUNCT
admet-2214	416	3	not	not	PART
admet-2214	416	4	applicable	applicable	ADJ
admet-2214	416	5	.	.	PUNCT
admet-2214	417	1	funding	funding	NOUN
admet-2214	417	2	:	:	PUNCT
admet-2214	417	3	no	no	DET
admet-2214	417	4	fund	fund	NOUN
admet-2214	417	5	was	be	AUX
admet-2214	417	6	received	receive	VERB
admet-2214	417	7	for	for	ADP
admet-2214	417	8	this	this	DET
admet-2214	417	9	review	review	NOUN
admet-2214	417	10	.	.	PUNCT
admet-2214	418	1	references	reference	NOUN
admet-2214	418	2	[	[	X
admet-2214	418	3	1	1	NUM
admet-2214	418	4	]	]	X
admet-2214	418	5	s.a	s.a	PROPN
admet-2214	418	6	.	.	PROPN
admet-2214	418	7	grimm	grimm	PROPN
admet-2214	418	8	,	,	PUNCT
admet-2214	418	9	m.c	m.c	PROPN
admet-2214	418	10	.	.	PUNCT
admet-2214	419	1	chamberlain	chamberlain	PROPN
admet-2214	419	2	.	.	PUNCT
admet-2214	420	1	brainstem	brainstem	NOUN
admet-2214	420	2	glioma	glioma	NOUN
admet-2214	420	3	.	.	PUNCT
admet-2214	421	1	current	current	ADJ
admet-2214	421	2	neurology	neurology	NOUN
admet-2214	421	3	and	and	CCONJ
admet-2214	421	4	neuroscience	neuroscience	NOUN
admet-2214	421	5	reports	report	NOUN
admet-2214	421	6	13(5	13(5	NUM
admet-2214	421	7	)	)	PUNCT
admet-2214	421	8	(	(	PUNCT
admet-2214	421	9	2013	2013	NUM
admet-2214	421	10	)	)	PUNCT
admet-2214	421	11	13:346	13:346	NUM
admet-2214	421	12	.	.	PUNCT
admet-2214	422	1	https://doi.org/10.1007/s11910-013-0346-3	https://doi.org/10.1007/s11910-013-0346-3	X
admet-2214	422	2	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	VERB
admet-2214	422	3	https://doi.org/10.1007/s11910-013-0346-3	https://doi.org/10.1007/s11910-013-0346-3	NUM
admet-2214	423	1	z.	z.	PROPN
admet-2214	423	2	presswala	presswala	PROPN
admet-2214	423	3	et	et	PROPN
admet-2214	423	4	al	al	PROPN
admet-2214	423	5	.	.	PROPN
admet-2214	423	6	admet	admet	PROPN
admet-2214	423	7	&	&	CCONJ
admet-2214	423	8	dmpk	dmpk	PROPN
admet-2214	423	9	12(3	12(3	PROPN
admet-2214	423	10	)	)	PUNCT
admet-2214	423	11	(	(	PUNCT
admet-2214	423	12	2024	2024	NUM
admet-2214	423	13	)	)	PUNCT
admet-2214	423	14	403	403	NUM
admet-2214	423	15	-	-	SYM
admet-2214	423	16	429	429	NUM
admet-2214	423	17	422	422	NUM
admet-2214	423	18	[	[	X
admet-2214	423	19	2	2	NUM
admet-2214	423	20	]	]	X
admet-2214	423	21	a.d	a.d	PROPN
admet-2214	423	22	.	.	PROPN
admet-2214	423	23	forman	forman	PROPN
admet-2214	423	24	,	,	PUNCT
admet-2214	423	25	w.c	w.c	PROPN
admet-2214	423	26	.	.	PROPN
admet-2214	423	27	black	black	PROPN
admet-2214	423	28	,	,	PUNCT
admet-2214	423	29	m.a	m.a	PROPN
admet-2214	423	30	.	.	PROPN
admet-2214	423	31	smith	smith	PROPN
admet-2214	423	32	,	,	PUNCT
admet-2214	423	33	b.	b.	PROPN
admet-2214	423	34	freidlin	freidlin	PROPN
admet-2214	423	35	,	,	PUNCT
admet-2214	423	36	l.a	l.a	PROPN
admet-2214	423	37	.	.	PROPN
admet-2214	423	38	gloeckler	gloeckler	PROPN
admet-2214	423	39	ries	ries	PROPN
admet-2214	423	40	,	,	PUNCT
admet-2214	423	41	r.	r.	PROPN
admet-2214	423	42	simon	simon	PROPN
admet-2214	423	43	.	.	PUNCT
admet-2214	424	1	re	re	ADP
admet-2214	424	2	:	:	PUNCT
admet-2214	424	3	trends	trend	NOUN
admet-2214	424	4	in	in	ADP
admet-2214	424	5	reported	report	VERB
admet-2214	424	6	incidence	incidence	NOUN
admet-2214	424	7	of	of	ADP
admet-2214	424	8	primary	primary	ADJ
admet-2214	424	9	malignant	malignant	ADJ
admet-2214	424	10	brain	brain	NOUN
admet-2214	424	11	tumors	tumor	NOUN
admet-2214	424	12	in	in	ADP
admet-2214	424	13	children	child	NOUN
admet-2214	424	14	in	in	ADP
admet-2214	424	15	the	the	DET
admet-2214	424	16	united	united	PROPN
admet-2214	424	17	states	states	PROPN
admet-2214	424	18	[	[	X
admet-2214	424	19	4	4	X
admet-2214	424	20	]	]	X
admet-2214	424	21	(	(	PUNCT
admet-2214	424	22	multiple	multiple	ADJ
admet-2214	424	23	letters	letter	NOUN
admet-2214	424	24	)	)	PUNCT
admet-2214	424	25	.	.	PUNCT
admet-2214	425	1	journal	journal	NOUN
admet-2214	425	2	of	of	ADP
admet-2214	425	3	the	the	DET
admet-2214	425	4	national	national	PROPN
admet-2214	425	5	cancer	cancer	PROPN
admet-2214	425	6	institute	institute	PROPN
admet-2214	425	7	91	91	NUM
admet-2214	425	8	(	(	PUNCT
admet-2214	425	9	1999	1999	NUM
admet-2214	425	10	)	)	PUNCT
admet-2214	425	11	648	648	NUM
admet-2214	425	12	-	-	SYM
admet-2214	425	13	64910	64910	NUM
admet-2214	425	14	.	.	PUNCT
admet-2214	426	1	https://doi.org/1093/jnci/91.7.648	https://doi.org/1093/jnci/91.7.648	PROPN
admet-2214	427	1	[	[	X
admet-2214	427	2	3	3	X
admet-2214	427	3	]	]	X
admet-2214	427	4	c.	c.	PROPN
admet-2214	427	5	ferraris	ferraris	PROPN
admet-2214	427	6	,	,	PUNCT
admet-2214	427	7	r.	r.	PROPN
admet-2214	427	8	cavalli	cavalli	PROPN
admet-2214	427	9	,	,	PUNCT
admet-2214	427	10	p.p	p.p	PROPN
admet-2214	427	11	.	.	PROPN
admet-2214	427	12	panciani	panciani	PROPN
admet-2214	427	13	,	,	PUNCT
admet-2214	427	14	l.	l.	PROPN
admet-2214	427	15	battaglia	battaglia	PROPN
admet-2214	427	16	.	.	PUNCT
admet-2214	428	1	overcoming	overcome	VERB
admet-2214	428	2	the	the	DET
admet-2214	428	3	blood	blood	NOUN
admet-2214	428	4	-	-	PUNCT
admet-2214	428	5	brain	brain	NOUN
admet-2214	428	6	barrier	barrier	NOUN
admet-2214	428	7	:	:	PUNCT
admet-2214	428	8	successes	success	NOUN
admet-2214	428	9	and	and	CCONJ
admet-2214	428	10	challenges	challenge	NOUN
admet-2214	428	11	in	in	ADP
admet-2214	428	12	developing	develop	VERB
admet-2214	428	13	nanoparticle	nanoparticle	NOUN
admet-2214	428	14	-	-	PUNCT
admet-2214	428	15	mediated	mediate	VERB
admet-2214	428	16	drug	drug	NOUN
admet-2214	428	17	delivery	delivery	NOUN
admet-2214	428	18	systems	system	NOUN
admet-2214	428	19	for	for	ADP
admet-2214	428	20	the	the	DET
admet-2214	428	21	treatment	treatment	NOUN
admet-2214	428	22	of	of	ADP
admet-2214	428	23	brain	brain	NOUN
admet-2214	428	24	tumours	tumour	NOUN
admet-2214	428	25	.	.	PUNCT
admet-2214	429	1	international	international	ADJ
admet-2214	429	2	journal	journal	PROPN
admet-2214	429	3	of	of	ADP
admet-2214	429	4	nanomedicine	nanomedicine	NOUN
admet-2214	429	5	15	15	NUM
admet-2214	429	6	(	(	PUNCT
admet-2214	429	7	2020	2020	NUM
admet-2214	429	8	)	)	PUNCT
admet-2214	429	9	2999	2999	NUM
admet-2214	429	10	-	-	SYM
admet-2214	429	11	3022	3022	NUM
admet-2214	429	12	https://doi.org/10.2147/ijn.s231479	https://doi.org/10.2147/ijn.s231479	NOUN
admet-2214	430	1	[	[	X
admet-2214	430	2	4	4	NUM
admet-2214	430	3	]	]	X
admet-2214	430	4	d.n	d.n	PROPN
admet-2214	430	5	.	.	PROPN
admet-2214	430	6	louis	louis	PROPN
admet-2214	430	7	,	,	PUNCT
admet-2214	430	8	a.	a.	PROPN
admet-2214	430	9	perry	perry	PROPN
admet-2214	430	10	,	,	PUNCT
admet-2214	430	11	g.	g.	PROPN
admet-2214	430	12	reifenberger	reifenberger	PROPN
admet-2214	430	13	,	,	PUNCT
admet-2214	430	14	a.	a.	PROPN
admet-2214	430	15	von	von	PROPN
admet-2214	430	16	deimling	deimling	PROPN
admet-2214	430	17	,	,	PUNCT
admet-2214	430	18	d.	d.	PROPN
admet-2214	430	19	figarella	figarella	NOUN
admet-2214	430	20	-	-	PUNCT
admet-2214	430	21	branger	branger	NOUN
admet-2214	430	22	,	,	PUNCT
admet-2214	430	23	w.k	w.k	PROPN
admet-2214	430	24	.	.	PROPN
admet-2214	430	25	cavenee	cavenee	PROPN
admet-2214	430	26	,	,	PUNCT
admet-2214	430	27	h.	h.	PROPN
admet-2214	430	28	ohgaki	ohgaki	PROPN
admet-2214	430	29	,	,	PUNCT
admet-2214	430	30	o.d	o.d	PROPN
admet-2214	430	31	.	.	PROPN
admet-2214	430	32	wiestler	wiestler	PROPN
admet-2214	430	33	,	,	PUNCT
admet-2214	430	34	p.	p.	PROPN
admet-2214	430	35	kleihues	kleihues	PROPN
admet-2214	430	36	,	,	PUNCT
admet-2214	430	37	d.w	d.w	PROPN
admet-2214	430	38	.	.	PROPN
admet-2214	430	39	ellison	ellison	PROPN
admet-2214	430	40	.	.	PUNCT
admet-2214	431	1	the	the	DET
admet-2214	431	2	2016	2016	NUM
admet-2214	431	3	world	world	PROPN
admet-2214	431	4	health	health	NOUN
admet-2214	431	5	organization	organization	NOUN
admet-2214	431	6	classification	classification	NOUN
admet-2214	431	7	of	of	ADP
admet-2214	431	8	tumors	tumor	NOUN
admet-2214	431	9	of	of	ADP
admet-2214	431	10	the	the	DET
admet-2214	431	11	central	central	ADJ
admet-2214	431	12	nervous	nervous	ADJ
admet-2214	431	13	system	system	NOUN
admet-2214	431	14	:	:	PUNCT
admet-2214	431	15	a	a	DET
admet-2214	431	16	summary	summary	NOUN
admet-2214	431	17	.	.	PUNCT
admet-2214	432	1	acta	acta	PROPN
admet-2214	432	2	neuropathologica	neuropathologica	PROPN
admet-2214	432	3	131	131	NUM
admet-2214	432	4	(	(	PUNCT
admet-2214	432	5	2016	2016	NUM
admet-2214	432	6	)	)	PUNCT
admet-2214	432	7	803	803	NUM
admet-2214	432	8	-	-	SYM
admet-2214	432	9	820	820	NUM
admet-2214	432	10	.	.	PUNCT
admet-2214	433	1	https://doi.org/10.1007/s00401-016-1545-1	https://doi.org/10.1007/s00401-016-1545-1	PUNCT
admet-2214	434	1	[	[	X
admet-2214	434	2	5	5	NUM
admet-2214	434	3	]	]	PUNCT
admet-2214	434	4	r.	r.	PROPN
admet-2214	434	5	chen	chen	PROPN
admet-2214	434	6	,	,	PUNCT
admet-2214	434	7	m.	m.	PROPN
admet-2214	434	8	smith	smith	PROPN
admet-2214	434	9	-	-	PUNCT
admet-2214	434	10	cohn	cohn	PROPN
admet-2214	434	11	,	,	PUNCT
admet-2214	434	12	a.l	a.l	PROPN
admet-2214	434	13	.	.	PROPN
admet-2214	434	14	cohen	cohen	PROPN
admet-2214	434	15	,	,	PUNCT
admet-2214	434	16	h.	h.	PROPN
admet-2214	434	17	colman	colman	PROPN
admet-2214	434	18	.	.	PUNCT
admet-2214	434	19	glioma	glioma	NOUN
admet-2214	434	20	subclassifications	subclassification	NOUN
admet-2214	434	21	and	and	CCONJ
admet-2214	434	22	their	their	PRON
admet-2214	434	23	clinical	clinical	ADJ
admet-2214	434	24	significance	significance	NOUN
admet-2214	434	25	.	.	PUNCT
admet-2214	435	1	neurotherapeutics	neurotherapeutics	PROPN
admet-2214	435	2	14	14	NUM
admet-2214	435	3	(	(	PUNCT
admet-2214	435	4	2017	2017	NUM
admet-2214	435	5	)	)	PUNCT
admet-2214	435	6	284	284	NUM
admet-2214	435	7	-	-	SYM
admet-2214	435	8	297	297	NUM
admet-2214	435	9	https://doi.org/10.1007/s13311-017-0519-x	https://doi.org/10.1007/s13311-017-0519-x	NOUN
admet-2214	435	10	[	[	X
admet-2214	435	11	6	6	NUM
admet-2214	435	12	]	]	X
admet-2214	435	13	d.	d.	PROPN
admet-2214	435	14	srikanthan	srikanthan	PROPN
admet-2214	435	15	,	,	PUNCT
admet-2214	435	16	m.s	m.s	PROPN
admet-2214	435	17	.	.	PROPN
admet-2214	435	18	taccone	taccone	PROPN
admet-2214	435	19	,	,	PUNCT
admet-2214	435	20	r.	r.	PROPN
admet-2214	435	21	van	van	PROPN
admet-2214	435	22	ommeren	ommeren	PROPN
admet-2214	435	23	,	,	PUNCT
admet-2214	435	24	j.	j.	PROPN
admet-2214	435	25	ishida	ishida	PROPN
admet-2214	435	26	,	,	PUNCT
admet-2214	435	27	s.l	s.l	PROPN
admet-2214	435	28	.	.	PROPN
admet-2214	435	29	krumholtz	krumholtz	PROPN
admet-2214	435	30	,	,	PUNCT
admet-2214	435	31	j.t	j.t	PROPN
admet-2214	435	32	.	.	PROPN
admet-2214	435	33	rutka	rutka	PROPN
admet-2214	435	34	.	.	PUNCT
admet-2214	436	1	diffuse	diffuse	VERB
admet-2214	436	2	intrinsic	intrinsic	ADJ
admet-2214	436	3	pontine	pontine	ADJ
admet-2214	436	4	glioma	glioma	NOUN
admet-2214	436	5	:	:	PUNCT
admet-2214	437	1	current	current	ADJ
admet-2214	437	2	insights	insight	NOUN
admet-2214	437	3	and	and	CCONJ
admet-2214	437	4	future	future	ADJ
admet-2214	437	5	directions	direction	NOUN
admet-2214	437	6	.	.	PUNCT
admet-2214	438	1	chinese	chinese	ADJ
admet-2214	438	2	neurosurgical	neurosurgical	PROPN
admet-2214	438	3	journal	journal	PROPN
admet-2214	438	4	7	7	NUM
admet-2214	438	5	(	(	PUNCT
admet-2214	438	6	2021	2021	NUM
admet-2214	438	7	)	)	PUNCT
admet-2214	438	8	6	6	NUM
admet-2214	438	9	https://doi.org/10.1186/s41016-020-00218-w	https://doi.org/10.1186/s41016-020-00218-w	NOUN
admet-2214	439	1	[	[	X
admet-2214	439	2	7	7	X
admet-2214	439	3	]	]	X
admet-2214	439	4	k.e	k.e	PROPN
admet-2214	439	5	.	.	PROPN
admet-2214	439	6	warren	warren	PROPN
admet-2214	439	7	.	.	PUNCT
admet-2214	440	1	diffuse	diffuse	VERB
admet-2214	440	2	intrinsic	intrinsic	ADJ
admet-2214	440	3	pontine	pontine	ADJ
admet-2214	440	4	glioma	glioma	NOUN
admet-2214	440	5	:	:	PUNCT
admet-2214	440	6	poised	poise	VERB
admet-2214	440	7	for	for	ADP
admet-2214	440	8	progress	progress	NOUN
admet-2214	440	9	.	.	PUNCT
admet-2214	441	1	frontiers	frontier	NOUN
admet-2214	441	2	in	in	ADP
admet-2214	441	3	oncology	oncology	NOUN
admet-2214	441	4	2	2	NUM
admet-2214	441	5	(	(	PUNCT
admet-2214	441	6	2012	2012	NUM
admet-2214	441	7	)	)	PUNCT
admet-2214	441	8	205	205	NUM
admet-2214	441	9	https://doi.org/10.3389/fonc.2012.00205	https://doi.org/10.3389/fonc.2012.00205	X
admet-2214	442	1	[	[	X
admet-2214	442	2	8	8	NUM
admet-2214	442	3	]	]	PUNCT
admet-2214	442	4	d.	d.	PROPN
admet-2214	442	5	hargrave	hargrave	PROPN
admet-2214	442	6	,	,	PUNCT
admet-2214	442	7	u.	u.	PROPN
admet-2214	442	8	bartels	bartels	PROPN
admet-2214	442	9	,	,	PUNCT
admet-2214	442	10	e.	e.	PROPN
admet-2214	442	11	bouffet	bouffet	PROPN
admet-2214	442	12	.	.	PUNCT
admet-2214	443	1	diffuse	diffuse	VERB
admet-2214	443	2	brainstem	brainstem	NOUN
admet-2214	443	3	glioma	glioma	NOUN
admet-2214	443	4	in	in	ADP
admet-2214	443	5	children	child	NOUN
admet-2214	443	6	:	:	PUNCT
admet-2214	443	7	critical	critical	ADJ
admet-2214	443	8	review	review	NOUN
admet-2214	443	9	of	of	ADP
admet-2214	443	10	clinical	clinical	ADJ
admet-2214	443	11	trials	trial	NOUN
admet-2214	443	12	.	.	PUNCT
admet-2214	444	1	lancet	lancet	NOUN
admet-2214	444	2	oncology	oncology	NOUN
admet-2214	444	3	7	7	NUM
admet-2214	444	4	(	(	PUNCT
admet-2214	444	5	2006	2006	NUM
admet-2214	444	6	)	)	PUNCT
admet-2214	444	7	241	241	NUM
admet-2214	444	8	-	-	SYM
admet-2214	444	9	248	248	NUM
admet-2214	444	10	.	.	PUNCT
admet-2214	445	1	https://doi.org/10.1016/s1470-2045(06)70615-5	https://doi.org/10.1016/s1470-2045(06)70615-5	PROPN
admet-2214	446	1	[	[	X
admet-2214	446	2	9	9	NUM
admet-2214	446	3	]	]	X
admet-2214	446	4	p.k	p.k	PROPN
admet-2214	446	5	.	.	PROPN
admet-2214	446	6	duffner	duffner	PROPN
admet-2214	446	7	,	,	PUNCT
admet-2214	446	8	m.e	m.e	PROPN
admet-2214	446	9	.	.	PROPN
admet-2214	446	10	cohen	cohen	PROPN
admet-2214	446	11	,	,	PUNCT
admet-2214	446	12	a.i	a.i	PROPN
admet-2214	446	13	.	.	PROPN
admet-2214	446	14	freeman	freeman	PROPN
admet-2214	446	15	.	.	PUNCT
admet-2214	447	1	pediatric	pediatric	ADJ
admet-2214	447	2	brain	brain	NOUN
admet-2214	447	3	tumors	tumor	NOUN
admet-2214	447	4	:	:	PUNCT
admet-2214	447	5	an	an	DET
admet-2214	447	6	overview	overview	NOUN
admet-2214	447	7	.	.	PUNCT
admet-2214	448	1	ca	can	AUX
admet-2214	448	2	:	:	PUNCT
admet-2214	448	3	a	a	DET
admet-2214	448	4	cancer	cancer	NOUN
admet-2214	448	5	journal	journal	NOUN
admet-2214	448	6	for	for	ADP
admet-2214	448	7	clinicians	clinician	NOUN
admet-2214	448	8	35(5	35(5	NUM
admet-2214	448	9	)	)	PUNCT
admet-2214	448	10	(	(	PUNCT
admet-2214	448	11	1985	1985	NUM
admet-2214	448	12	)	)	PUNCT
admet-2214	448	13	287	287	NUM
admet-2214	448	14	-	-	SYM
admet-2214	448	15	301	301	NUM
admet-2214	448	16	.	.	PUNCT
admet-2214	449	1	https://doi.org/10.3322/canjclin.35.5.287	https://doi.org/10.3322/canjclin.35.5.287	PROPN
admet-2214	450	1	[	[	X
admet-2214	450	2	10	10	NUM
admet-2214	450	3	]	]	X
admet-2214	450	4	c.	c.	PROPN
admet-2214	450	5	kolsteeg	kolsteeg	PROPN
admet-2214	450	6	,	,	PUNCT
admet-2214	450	7	e.	e.	PROPN
admet-2214	450	8	hulleman	hulleman	PROPN
admet-2214	450	9	,	,	PUNCT
admet-2214	450	10	j.	j.	PROPN
admet-2214	450	11	bianco	bianco	PROPN
admet-2214	450	12	.	.	PUNCT
admet-2214	451	1	emerging	emerge	VERB
admet-2214	451	2	nanomedical	nanomedical	ADJ
admet-2214	451	3	strategies	strategy	NOUN
admet-2214	451	4	for	for	ADP
admet-2214	451	5	direct	direct	ADJ
admet-2214	451	6	targeting	targeting	NOUN
admet-2214	451	7	of	of	ADP
admet-2214	451	8	pediatric	pediatric	ADJ
admet-2214	451	9	and	and	CCONJ
admet-2214	451	10	adult	adult	NOUN
admet-2214	451	11	diffuse	diffuse	NOUN
admet-2214	451	12	gliomas	glioma	NOUN
admet-2214	451	13	.	.	PUNCT
admet-2214	452	1	british	british	ADJ
admet-2214	452	2	journal	journal	PROPN
admet-2214	452	3	of	of	ADP
admet-2214	452	4	cancer	cancer	NOUN
admet-2214	452	5	127	127	NUM
admet-2214	452	6	(	(	PUNCT
admet-2214	452	7	2022	2022	NUM
admet-2214	452	8	)	)	PUNCT
admet-2214	452	9	1193	1193	NUM
admet-2214	452	10	-	-	SYM
admet-2214	452	11	1200	1200	NUM
admet-2214	452	12	https://doi.org/10.1038/s41416-022-01884-6	https://doi.org/10.1038/s41416-022-01884-6	NOUN
admet-2214	453	1	[	[	X
admet-2214	453	2	11	11	NUM
admet-2214	453	3	]	]	PUNCT
admet-2214	453	4	dipg	dipg	NOUN
admet-2214	453	5	:	:	PUNCT
admet-2214	453	6	a	a	DET
admet-2214	453	7	definition	definition	NOUN
admet-2214	453	8	and	and	CCONJ
admet-2214	453	9	brief	brief	ADJ
admet-2214	453	10	history	history	NOUN
admet-2214	453	11	.	.	PUNCT
admet-2214	454	1	https://mithilprasadfoundation.org/blog/dipg-definition-andhistory	https://mithilprasadfoundation.org/blog/dipg-definition-andhistory	PROPN
admet-2214	454	2	(	(	PUNCT
admet-2214	454	3	accessed	access	VERB
admet-2214	454	4	on	on	ADP
admet-2214	454	5	20/10/2023	20/10/2023	NUM
admet-2214	454	6	)	)	PUNCT
admet-2214	454	7	.	.	PUNCT
admet-2214	455	1	[	[	X
admet-2214	455	2	12	12	NUM
admet-2214	455	3	]	]	X
admet-2214	455	4	j.e	j.e	PROPN
admet-2214	455	5	.	.	PROPN
admet-2214	455	6	pellot	pellot	PROPN
admet-2214	455	7	,	,	PUNCT
admet-2214	455	8	o	o	NOUN
admet-2214	455	9	,	,	PUNCT
admet-2214	455	10	de	de	PROPN
admet-2214	455	11	jesus	jesus	PROPN
admet-2214	455	12	.	.	PUNCT
admet-2214	456	1	diffuse	diffuse	VERB
admet-2214	456	2	intrinsic	intrinsic	ADJ
admet-2214	456	3	pontine	pontine	ADJ
admet-2214	456	4	glioma	glioma	NOUN
admet-2214	456	5	.	.	PUNCT
admet-2214	457	1	statpearls	statpearl	NOUN
admet-2214	458	1	[	[	X
admet-2214	458	2	internet	internet	NOUN
admet-2214	458	3	]	]	PUNCT
admet-2214	458	4	.	.	PUNCT
admet-2214	459	1	statpearls	statpearls	PROPN
admet-2214	459	2	publishing	publishing	NOUN
admet-2214	459	3	(	(	PUNCT
admet-2214	459	4	2023	2023	NUM
admet-2214	459	5	)	)	PUNCT
admet-2214	459	6	.	.	PUNCT
admet-2214	460	1	https://www.ncbi.nlm.nih.gov/books/nbk560640/	https://www.ncbi.nlm.nih.gov/books/nbk560640/	PROPN
admet-2214	460	2	[	[	X
admet-2214	460	3	13	13	NUM
admet-2214	460	4	]	]	PUNCT
admet-2214	460	5	j.	j.	PROPN
admet-2214	460	6	fangusaro	fangusaro	PROPN
admet-2214	460	7	.	.	PUNCT
admet-2214	461	1	pediatric	pediatric	ADJ
admet-2214	461	2	high	high	ADJ
admet-2214	461	3	-	-	PUNCT
admet-2214	461	4	grade	grade	NOUN
admet-2214	461	5	gliomas	glioma	NOUN
admet-2214	461	6	and	and	CCONJ
admet-2214	461	7	diffuse	diffuse	VERB
admet-2214	461	8	intrinsic	intrinsic	ADJ
admet-2214	461	9	pontine	pontine	ADJ
admet-2214	461	10	gliomas	glioma	NOUN
admet-2214	461	11	.	.	PUNCT
admet-2214	462	1	journal	journal	NOUN
admet-2214	462	2	of	of	ADP
admet-2214	462	3	child	child	NOUN
admet-2214	462	4	neurology	neurology	NOUN
admet-2214	462	5	24	24	NUM
admet-2214	462	6	(	(	PUNCT
admet-2214	462	7	2009	2009	NUM
admet-2214	462	8	)	)	PUNCT
admet-2214	462	9	1409	1409	NUM
admet-2214	462	10	-	-	SYM
admet-2214	462	11	1417	1417	NUM
admet-2214	462	12	.	.	PUNCT
admet-2214	463	1	https://doi.org/10.1177/0883073809338960	https://doi.org/10.1177/0883073809338960	X
admet-2214	464	1	[	[	X
admet-2214	464	2	14	14	NUM
admet-2214	464	3	]	]	X
admet-2214	464	4	u.	u.	PROPN
admet-2214	464	5	bartels	bartels	PROPN
admet-2214	464	6	,	,	PUNCT
admet-2214	464	7	c.	c.	PROPN
admet-2214	464	8	hawkins	hawkins	PROPN
admet-2214	464	9	,	,	PUNCT
admet-2214	464	10	g.	g.	PROPN
admet-2214	464	11	vézina	vézina	PROPN
admet-2214	464	12	,	,	PUNCT
admet-2214	464	13	l.	l.	PROPN
admet-2214	464	14	kun	kun	PROPN
admet-2214	464	15	,	,	PUNCT
admet-2214	464	16	m.	m.	NOUN
admet-2214	464	17	souweidane	souweidane	PROPN
admet-2214	464	18	,	,	PUNCT
admet-2214	464	19	e.	e.	PROPN
admet-2214	464	20	bouffet	bouffet	PROPN
admet-2214	464	21	.	.	PUNCT
admet-2214	465	1	proceedings	proceeding	NOUN
admet-2214	465	2	of	of	ADP
admet-2214	465	3	the	the	DET
admet-2214	465	4	diffuse	diffuse	NOUN
admet-2214	465	5	intrinsic	intrinsic	ADJ
admet-2214	465	6	pontine	pontine	ADJ
admet-2214	465	7	glioma	glioma	NOUN
admet-2214	465	8	(	(	PUNCT
admet-2214	465	9	dipg	dipg	PROPN
admet-2214	465	10	)	)	PUNCT
admet-2214	465	11	toronto	toronto	PROPN
admet-2214	465	12	think	think	VERB
admet-2214	465	13	tank	tank	NOUN
admet-2214	465	14	:	:	PUNCT
admet-2214	465	15	advancing	advance	VERB
admet-2214	465	16	basic	basic	ADJ
admet-2214	465	17	and	and	CCONJ
admet-2214	465	18	translational	translational	ADJ
admet-2214	465	19	research	research	NOUN
admet-2214	465	20	and	and	CCONJ
admet-2214	465	21	cooperation	cooperation	NOUN
admet-2214	465	22	in	in	ADP
admet-2214	465	23	dipg	dipg	PROPN
admet-2214	465	24	.	.	PUNCT
admet-2214	466	1	journal	journal	PROPN
admet-2214	466	2	of	of	ADP
admet-2214	466	3	neuro	neuro	PROPN
admet-2214	466	4	-	-	PUNCT
admet-2214	466	5	oncology	oncology	NOUN
admet-2214	466	6	105	105	NUM
admet-2214	466	7	(	(	PUNCT
admet-2214	466	8	2011	2011	NUM
admet-2214	466	9	)	)	PUNCT
admet-2214	466	10	119	119	NUM
admet-2214	466	11	-	-	SYM
admet-2214	466	12	125	125	NUM
admet-2214	466	13	https://doi.org/10.1007/s11060-011-0704-4	https://doi.org/10.1007/s11060-011-0704-4	NUM
admet-2214	467	1	[	[	X
admet-2214	467	2	15	15	NUM
admet-2214	467	3	]	]	X
admet-2214	467	4	s.n	s.n	PROPN
admet-2214	467	5	.	.	PROPN
admet-2214	467	6	krieger	krieger	PROPN
admet-2214	467	7	,	,	PUNCT
admet-2214	467	8	m.n	m.n	PROPN
admet-2214	467	9	.	.	PROPN
admet-2214	467	10	streicher	streicher	PROPN
admet-2214	467	11	,	,	PUNCT
admet-2214	467	12	r.	r.	PROPN
admet-2214	467	13	trampel	trampel	PROPN
admet-2214	467	14	,	,	PUNCT
admet-2214	467	15	r.	r.	PROPN
admet-2214	467	16	turner	turner	PROPN
admet-2214	467	17	.	.	PUNCT
admet-2214	468	1	cerebral	cerebral	ADJ
admet-2214	468	2	blood	blood	NOUN
admet-2214	468	3	volume	volume	NOUN
admet-2214	468	4	changes	change	NOUN
admet-2214	468	5	during	during	ADP
admet-2214	468	6	brain	brain	NOUN
admet-2214	468	7	activation	activation	NOUN
admet-2214	468	8	.	.	PUNCT
admet-2214	469	1	journal	journal	NOUN
admet-2214	469	2	of	of	ADP
admet-2214	469	3	cerebral	cerebral	ADJ
admet-2214	469	4	blood	blood	NOUN
admet-2214	469	5	flow	flow	NOUN
admet-2214	469	6	and	and	CCONJ
admet-2214	469	7	metabolism	metabolism	NOUN
admet-2214	469	8	32	32	NUM
admet-2214	469	9	(	(	PUNCT
admet-2214	469	10	2012	2012	NUM
admet-2214	469	11	)	)	PUNCT
admet-2214	469	12	1618	1618	NUM
admet-2214	469	13	-	-	SYM
admet-2214	469	14	1631	1631	NUM
admet-2214	469	15	.	.	PUNCT
admet-2214	470	1	https://doi.org/10.1038/jcbfm.2012.63	https://doi.org/10.1038/jcbfm.2012.63	PROPN
admet-2214	470	2	.	.	PUNCT
admet-2214	471	1	[	[	X
admet-2214	471	2	16	16	NUM
admet-2214	471	3	]	]	PUNCT
admet-2214	471	4	p.	p.	NOUN
admet-2214	471	5	buczkowicz	buczkowicz	NOUN
admet-2214	471	6	,	,	PUNCT
admet-2214	471	7	c.	c.	PROPN
admet-2214	471	8	hoeman	hoeman	NOUN
admet-2214	471	9	,	,	PUNCT
admet-2214	471	10	p.	p.	PROPN
admet-2214	471	11	rakopoulos	rakopoulos	PROPN
admet-2214	471	12	,	,	PUNCT
admet-2214	471	13	s.	s.	PROPN
admet-2214	471	14	pajovic	pajovic	PROPN
admet-2214	471	15	,	,	PUNCT
admet-2214	471	16	l.	l.	PROPN
admet-2214	471	17	letourneau	letourneau	PROPN
admet-2214	471	18	,	,	PUNCT
admet-2214	471	19	m.	m.	NOUN
admet-2214	471	20	dzamba	dzamba	NOUN
admet-2214	471	21	,	,	PUNCT
admet-2214	471	22	a.	a.	PROPN
admet-2214	471	23	morrison	morrison	PROPN
admet-2214	471	24	,	,	PUNCT
admet-2214	471	25	p.	p.	PROPN
admet-2214	471	26	lewis	lewis	PROPN
admet-2214	471	27	,	,	PUNCT
admet-2214	471	28	e.	e.	PROPN
admet-2214	471	29	bouffet	bouffet	PROPN
admet-2214	471	30	,	,	PUNCT
admet-2214	471	31	u.	u.	PROPN
admet-2214	471	32	bartels	bartels	PROPN
admet-2214	471	33	,	,	PUNCT
admet-2214	471	34	j.	j.	PROPN
admet-2214	471	35	zuccaro	zuccaro	PROPN
admet-2214	471	36	,	,	PUNCT
admet-2214	471	37	s.	s.	PROPN
admet-2214	471	38	agnihotri	agnihotri	PROPN
admet-2214	471	39	,	,	PUNCT
admet-2214	471	40	s.	s.	PROPN
admet-2214	471	41	ryall	ryall	PROPN
admet-2214	471	42	,	,	PUNCT
admet-2214	471	43	m.	m.	NOUN
admet-2214	471	44	barszczyk	barszczyk	PROPN
admet-2214	471	45	,	,	PUNCT
admet-2214	471	46	y.	y.	PROPN
admet-2214	471	47	chornenkyy	chornenkyy	PROPN
admet-2214	471	48	,	,	PUNCT
admet-2214	471	49	m.	m.	NOUN
admet-2214	471	50	bourgey	bourgey	PROPN
admet-2214	471	51	,	,	PUNCT
admet-2214	471	52	g.	g.	PROPN
admet-2214	471	53	bourque	bourque	PROPN
admet-2214	471	54	,	,	PUNCT
admet-2214	471	55	a.	a.	PROPN
admet-2214	471	56	montpetit	montpetit	PROPN
admet-2214	471	57	,	,	PUNCT
admet-2214	471	58	f.	f.	PROPN
admet-2214	471	59	cordero	cordero	PROPN
admet-2214	471	60	,	,	PUNCT
admet-2214	471	61	p.	p.	PROPN
admet-2214	471	62	castelo	castelo	PROPN
admet-2214	471	63	-	-	PUNCT
admet-2214	471	64	branco	branco	PROPN
admet-2214	471	65	,	,	PUNCT
admet-2214	471	66	j.	j.	PROPN
admet-2214	471	67	mangerel	mangerel	PROPN
admet-2214	471	68	,	,	PUNCT
admet-2214	471	69	u.	u.	PROPN
admet-2214	471	70	tabori	tabori	PROPN
admet-2214	471	71	,	,	PUNCT
admet-2214	471	72	k.c	k.c	PROPN
admet-2214	471	73	.	.	PROPN
admet-2214	471	74	ho	ho	PROPN
admet-2214	471	75	,	,	PUNCT
admet-2214	471	76	a.	a.	PROPN
admet-2214	471	77	huang	huang	PROPN
admet-2214	471	78	,	,	PUNCT
admet-2214	471	79	k.r	k.r	PROPN
admet-2214	471	80	.	.	PROPN
admet-2214	471	81	taylor	taylor	PROPN
admet-2214	471	82	,	,	PUNCT
admet-2214	471	83	a.	a.	PROPN
admet-2214	471	84	mackay	mackay	PROPN
admet-2214	471	85	,	,	PUNCT
admet-2214	471	86	a.e	a.e	PROPN
admet-2214	471	87	.	.	PROPN
admet-2214	471	88	bendel	bendel	PROPN
admet-2214	471	89	,	,	PUNCT
admet-2214	471	90	j.	j.	PROPN
admet-2214	471	91	nazarian	nazarian	PROPN
admet-2214	471	92	,	,	PUNCT
admet-2214	471	93	j.r	j.r	PROPN
admet-2214	471	94	.	.	PROPN
admet-2214	471	95	fangusaro	fangusaro	PROPN
admet-2214	471	96	,	,	PUNCT
admet-2214	471	97	m.a	m.a	PROPN
admet-2214	471	98	.	.	PROPN
admet-2214	471	99	karajannis	karajannis	PROPN
admet-2214	471	100	,	,	PUNCT
admet-2214	471	101	d.	d.	PROPN
admet-2214	471	102	zagzag	zagzag	PROPN
admet-2214	471	103	,	,	PUNCT
admet-2214	471	104	n.k	n.k	PROPN
admet-2214	471	105	.	.	PROPN
admet-2214	471	106	foreman	foreman	NOUN
admet-2214	471	107	,	,	PUNCT
admet-2214	471	108	a.	a.	PROPN
admet-2214	471	109	donson	donson	PROPN
admet-2214	471	110	,	,	PUNCT
admet-2214	471	111	j.	j.	PROPN
admet-2214	471	112	v.	v.	PROPN
admet-2214	471	113	hegert	hegert	PROPN
admet-2214	471	114	,	,	PUNCT
admet-2214	471	115	a.	a.	PROPN
admet-2214	471	116	smith	smith	PROPN
admet-2214	471	117	,	,	PUNCT
admet-2214	471	118	j.	j.	PROPN
admet-2214	471	119	chan	chan	PROPN
admet-2214	471	120	,	,	PUNCT
admet-2214	471	121	l.	l.	PROPN
admet-2214	471	122	lafay	lafay	PROPN
admet-2214	471	123	-	-	PUNCT
admet-2214	471	124	cousin	cousin	NOUN
admet-2214	471	125	,	,	PUNCT
admet-2214	471	126	s.	s.	PROPN
admet-2214	471	127	dunn	dunn	PROPN
admet-2214	471	128	,	,	PUNCT
admet-2214	471	129	j.	j.	PROPN
admet-2214	471	130	hukin	hukin	PROPN
admet-2214	471	131	,	,	PUNCT
admet-2214	471	132	c.	c.	PROPN
admet-2214	471	133	dunham	dunham	PROPN
admet-2214	471	134	,	,	PUNCT
admet-2214	471	135	k.	k.	PROPN
admet-2214	471	136	scheinemann	scheinemann	PROPN
admet-2214	471	137	,	,	PUNCT
admet-2214	471	138	j.	j.	PROPN
admet-2214	471	139	michaud	michaud	PROPN
admet-2214	471	140	,	,	PUNCT
admet-2214	471	141	s.	s.	PROPN
admet-2214	471	142	zelcer	zelcer	PROPN
admet-2214	471	143	,	,	PUNCT
admet-2214	471	144	d.	d.	PROPN
admet-2214	471	145	ramsay	ramsay	PROPN
admet-2214	471	146	,	,	PUNCT
admet-2214	471	147	j.	j.	PROPN
admet-2214	471	148	cain	cain	PROPN
admet-2214	471	149	,	,	PUNCT
admet-2214	471	150	c.	c.	PROPN
admet-2214	471	151	brennan	brennan	PROPN
admet-2214	471	152	,	,	PUNCT
admet-2214	471	153	m.m	m.m	PROPN
admet-2214	471	154	.	.	PROPN
admet-2214	471	155	souweidane	souweidane	PROPN
admet-2214	471	156	,	,	PUNCT
admet-2214	471	157	c.	c.	PROPN
admet-2214	471	158	jones	jones	PROPN
admet-2214	471	159	,	,	PUNCT
admet-2214	471	160	c.d	c.d	PROPN
admet-2214	471	161	.	.	PROPN
admet-2214	471	162	allis	allis	PROPN
admet-2214	471	163	,	,	PUNCT
admet-2214	471	164	m.	m.	NOUN
admet-2214	471	165	brudno	brudno	PROPN
admet-2214	471	166	,	,	PUNCT
admet-2214	471	167	o.	o.	PROPN
admet-2214	471	168	becher	becher	PROPN
admet-2214	471	169	,	,	PUNCT
admet-2214	471	170	c.	c.	PROPN
admet-2214	471	171	hawkins	hawkins	PROPN
admet-2214	471	172	.	.	PUNCT
admet-2214	472	1	genomic	genomic	ADJ
admet-2214	472	2	analysis	analysis	NOUN
admet-2214	472	3	of	of	ADP
admet-2214	472	4	diffuse	diffuse	ADJ
admet-2214	472	5	intrinsic	intrinsic	ADJ
admet-2214	472	6	pontine	pontine	ADJ
admet-2214	472	7	gliomas	glioma	NOUN
admet-2214	472	8	identifies	identify	VERB
admet-2214	472	9	three	three	NUM
admet-2214	472	10	molecular	molecular	ADJ
admet-2214	472	11	subgroups	subgroup	NOUN
admet-2214	472	12	and	and	CCONJ
admet-2214	472	13	recurrent	recurrent	ADJ
admet-2214	472	14	activating	activate	VERB
admet-2214	472	15	acvr1	acvr1	NOUN
admet-2214	472	16	mutations	mutation	NOUN
admet-2214	472	17	.	.	PUNCT
admet-2214	473	1	nature	nature	NOUN
admet-2214	473	2	genetics	genetic	NOUN
admet-2214	473	3	46	46	NUM
admet-2214	473	4	(	(	PUNCT
admet-2214	473	5	2014	2014	NUM
admet-2214	473	6	)	)	PUNCT
admet-2214	473	7	451	451	NUM
admet-2214	473	8	-	-	SYM
admet-2214	473	9	456	456	NUM
admet-2214	473	10	.	.	PUNCT
admet-2214	473	11	https://doi.org/10.1038/ng.2936	https://doi.org/10.1038/ng.2936	PUNCT
admet-2214	474	1	[	[	X
admet-2214	474	2	17	17	NUM
admet-2214	474	3	]	]	PUNCT
admet-2214	474	4	p.	p.	NOUN
admet-2214	474	5	buczkowicz	buczkowicz	NOUN
admet-2214	474	6	,	,	PUNCT
admet-2214	474	7	c.	c.	PROPN
admet-2214	474	8	hawkins	hawkins	PROPN
admet-2214	474	9	.	.	PUNCT
admet-2214	475	1	pathology	pathology	NOUN
admet-2214	475	2	,	,	PUNCT
admet-2214	475	3	molecular	molecular	ADJ
admet-2214	475	4	genetics	genetic	NOUN
admet-2214	475	5	,	,	PUNCT
admet-2214	475	6	and	and	CCONJ
admet-2214	475	7	epigenetics	epigenetic	NOUN
admet-2214	475	8	of	of	ADP
admet-2214	475	9	diffuse	diffuse	NOUN
admet-2214	475	10	intrinsic	intrinsic	ADJ
admet-2214	475	11	pontine	pontine	ADJ
admet-2214	475	12	glioma	glioma	NOUN
admet-2214	475	13	.	.	PUNCT
admet-2214	476	1	frontiers	frontier	NOUN
admet-2214	476	2	in	in	ADP
admet-2214	476	3	oncology	oncology	NOUN
admet-2214	476	4	5	5	NUM
admet-2214	476	5	(	(	PUNCT
admet-2214	476	6	2015	2015	NUM
admet-2214	476	7	)	)	PUNCT
admet-2214	476	8	147	147	NUM
admet-2214	476	9	.	.	PUNCT
admet-2214	477	1	https://doi.org/10.3389/fonc.2015.00147	https://doi.org/10.3389/fonc.2015.00147	PROPN
admet-2214	477	2	https://doi.org/1093/jnci/91.7.648	https://doi.org/1093/jnci/91.7.648	PROPN
admet-2214	477	3	https://doi.org/10.2147/ijn.s231479	https://doi.org/10.2147/ijn.s231479	NOUN
admet-2214	477	4	https://doi.org/10.1007/s00401-016-1545-1	https://doi.org/10.1007/s00401-016-1545-1	PROPN
admet-2214	477	5	https://doi.org/10.1007/s13311-017-0519-x	https://doi.org/10.1007/s13311-017-0519-x	PROPN
admet-2214	477	6	https://doi.org/10.1186/s41016-020-00218-w	https://doi.org/10.1186/s41016-020-00218-w	NOUN
admet-2214	477	7	https://doi.org/10.1016/s1470-2045(06)70615-5	https://doi.org/10.1016/s1470-2045(06)70615-5	PROPN
admet-2214	477	8	https://doi.org/10.3322/canjclin.35.5.287	https://doi.org/10.3322/canjclin.35.5.287	PROPN
admet-2214	477	9	https://doi.org/10.1038/s41416-022-01884-6	https://doi.org/10.1038/s41416-022-01884-6	PROPN
admet-2214	477	10	https://mithilprasadfoundation.org/blog/dipg-definition-and-history	https://mithilprasadfoundation.org/blog/dipg-definition-and-history	NOUN
admet-2214	477	11	https://mithilprasadfoundation.org/blog/dipg-definition-and-history	https://mithilprasadfoundation.org/blog/dipg-definition-and-history	PROPN
admet-2214	478	1	https://www.ncbi.nlm.nih.gov/books/nbk560640/	https://www.ncbi.nlm.nih.gov/books/nbk560640/	PROPN
admet-2214	478	2	https://doi.org/10.1177/0883073809338960	https://doi.org/10.1177/0883073809338960	ADP
admet-2214	478	3	https://doi.org/10.1007/s11060-011-0704-4	https://doi.org/10.1007/s11060-011-0704-4	NUM
admet-2214	479	1	https://doi.org/10.1038/jcbfm.2012.63	https://doi.org/10.1038/jcbfm.2012.63	INTJ
admet-2214	479	2	https://doi.org/10.1038/ng.2936	https://doi.org/10.1038/ng.2936	PUNCT
admet-2214	480	1	https://doi.org/10.3389/fonc.2015.00147	https://doi.org/10.3389/fonc.2015.00147	PROPN
admet-2214	480	2	admet	admet	PROPN
admet-2214	480	3	&	&	CCONJ
admet-2214	480	4	dmpk	dmpk	PROPN
admet-2214	480	5	12(3	12(3	PROPN
admet-2214	480	6	)	)	PUNCT
admet-2214	480	7	(	(	PUNCT
admet-2214	480	8	2024	2024	NUM
admet-2214	480	9	)	)	PUNCT
admet-2214	480	10	403	403	NUM
admet-2214	480	11	-	-	SYM
admet-2214	480	12	429	429	NUM
admet-2214	480	13	addressing	address	VERB
admet-2214	480	14	barriers	barrier	NOUN
admet-2214	480	15	in	in	ADP
admet-2214	480	16	diffuse	diffuse	ADJ
admet-2214	480	17	intrinsic	intrinsic	ADJ
admet-2214	480	18	pontine	pontine	ADJ
admet-2214	480	19	glioma	glioma	NOUN
admet-2214	480	20	doi	doi	NOUN
admet-2214	480	21	:	:	PUNCT
admet-2214	480	22	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	480	23	423	423	NUM
admet-2214	481	1	[	[	SYM
admet-2214	481	2	18	18	NUM
admet-2214	481	3	]	]	X
admet-2214	481	4	p.w	p.w	PROPN
admet-2214	481	5	.	.	PROPN
admet-2214	481	6	lewis	lewis	PROPN
admet-2214	481	7	,	,	PUNCT
admet-2214	481	8	m.m	m.m	PROPN
admet-2214	481	9	.	.	PROPN
admet-2214	481	10	müller	müller	PROPN
admet-2214	481	11	,	,	PUNCT
admet-2214	481	12	m.s	m.s	PROPN
admet-2214	481	13	.	.	PROPN
admet-2214	481	14	koletsky	koletsky	PROPN
admet-2214	481	15	,	,	PUNCT
admet-2214	481	16	f.	f.	PROPN
admet-2214	481	17	cordero	cordero	PROPN
admet-2214	481	18	,	,	PUNCT
admet-2214	481	19	s.	s.	PROPN
admet-2214	481	20	lin	lin	PROPN
admet-2214	481	21	,	,	PUNCT
admet-2214	481	22	l.a	l.a	PROPN
admet-2214	481	23	.	.	PROPN
admet-2214	481	24	banaszynski	banaszynski	PROPN
admet-2214	481	25	,	,	PUNCT
admet-2214	481	26	b.a	b.a	PROPN
admet-2214	481	27	.	.	PROPN
admet-2214	481	28	garcia	garcia	PROPN
admet-2214	481	29	,	,	PUNCT
admet-2214	481	30	t.w	t.w	PROPN
admet-2214	481	31	.	.	PROPN
admet-2214	481	32	muir	muir	PROPN
admet-2214	481	33	,	,	PUNCT
admet-2214	481	34	o.j	o.j	PROPN
admet-2214	481	35	.	.	PROPN
admet-2214	481	36	becher	becher	PROPN
admet-2214	481	37	,	,	PUNCT
admet-2214	481	38	c.d	c.d	PROPN
admet-2214	481	39	.	.	PROPN
admet-2214	481	40	allis	allis	PROPN
admet-2214	481	41	.	.	PUNCT
admet-2214	482	1	inhibition	inhibition	NOUN
admet-2214	482	2	of	of	ADP
admet-2214	482	3	prc2	prc2	NOUN
admet-2214	482	4	activity	activity	NOUN
admet-2214	482	5	by	by	ADP
admet-2214	482	6	a	a	DET
admet-2214	482	7	gain	gain	NOUN
admet-2214	482	8	-	-	PUNCT
admet-2214	482	9	of	of	ADP
admet-2214	482	10	-	-	PUNCT
admet-2214	482	11	function	function	NOUN
admet-2214	482	12	h3	h3	NOUN
admet-2214	482	13	mutation	mutation	NOUN
admet-2214	482	14	found	find	VERB
admet-2214	482	15	in	in	ADP
admet-2214	482	16	pediatric	pediatric	ADJ
admet-2214	482	17	glioblastoma	glioblastoma	NOUN
admet-2214	482	18	.	.	PUNCT
admet-2214	483	1	science	science	NOUN
admet-2214	483	2	340	340	NUM
admet-2214	483	3	(	(	PUNCT
admet-2214	483	4	6134	6134	NUM
admet-2214	483	5	)	)	PUNCT
admet-2214	483	6	,	,	PUNCT
admet-2214	483	7	(	(	PUNCT
admet-2214	483	8	2013	2013	NUM
admet-2214	483	9	)	)	PUNCT
admet-2214	483	10	857	857	NUM
admet-2214	483	11	-	-	SYM
admet-2214	483	12	861	861	NUM
admet-2214	483	13	.	.	PUNCT
admet-2214	483	14	https://doi.org/	https://doi.org/	ADP
admet-2214	483	15	10.1126	10.1126	NUM
admet-2214	483	16	/	/	SYM
admet-2214	484	1	science.1232245	science.1232245	NOUN
admet-2214	484	2	[	[	X
admet-2214	484	3	19	19	NUM
admet-2214	484	4	]	]	X
admet-2214	484	5	d.	d.	PROPN
admet-2214	484	6	castel	castel	PROPN
admet-2214	484	7	,	,	PUNCT
admet-2214	484	8	c.	c.	PROPN
admet-2214	484	9	philippe	philippe	PROPN
admet-2214	484	10	,	,	PUNCT
admet-2214	484	11	r.	r.	PROPN
admet-2214	484	12	calmon	calmon	PROPN
admet-2214	484	13	,	,	PUNCT
admet-2214	484	14	l.	l.	PROPN
admet-2214	484	15	le	le	PROPN
admet-2214	484	16	dret	dret	PROPN
admet-2214	484	17	,	,	PUNCT
admet-2214	484	18	n.	n.	PROPN
admet-2214	484	19	truffaux	truffaux	PROPN
admet-2214	484	20	,	,	PUNCT
admet-2214	484	21	n.	n.	PROPN
admet-2214	484	22	boddaert	boddaert	PROPN
admet-2214	484	23	,	,	PUNCT
admet-2214	484	24	m.	m.	NOUN
admet-2214	484	25	pagès	pagès	PROPN
admet-2214	484	26	,	,	PUNCT
admet-2214	484	27	k.r	k.r	PROPN
admet-2214	484	28	.	.	PROPN
admet-2214	484	29	taylor	taylor	PROPN
admet-2214	484	30	,	,	PUNCT
admet-2214	484	31	p.	p.	NOUN
admet-2214	484	32	saulnier	saulnier	PROPN
admet-2214	484	33	,	,	PUNCT
admet-2214	484	34	l.	l.	PROPN
admet-2214	484	35	lacroix	lacroix	PROPN
admet-2214	484	36	,	,	PUNCT
admet-2214	484	37	a.	a.	PROPN
admet-2214	484	38	mackay	mackay	PROPN
admet-2214	484	39	,	,	PUNCT
admet-2214	484	40	c.	c.	PROPN
admet-2214	484	41	jones	jones	PROPN
admet-2214	484	42	,	,	PUNCT
admet-2214	484	43	c.	c.	PROPN
admet-2214	484	44	sainte	sainte	PROPN
admet-2214	484	45	-	-	PUNCT
admet-2214	484	46	rose	rise	VERB
admet-2214	484	47	,	,	PUNCT
admet-2214	484	48	t.	t.	NOUN
admet-2214	484	49	blauwblomme	blauwblomme	PROPN
admet-2214	484	50	,	,	PUNCT
admet-2214	484	51	f.	f.	PROPN
admet-2214	484	52	andreiuolo	andreiuolo	PROPN
admet-2214	484	53	,	,	PUNCT
admet-2214	484	54	s.	s.	PROPN
admet-2214	484	55	puget	puget	PROPN
admet-2214	484	56	,	,	PUNCT
admet-2214	484	57	j.	j.	PROPN
admet-2214	484	58	grill	grill	PROPN
admet-2214	484	59	,	,	PUNCT
admet-2214	484	60	p.	p.	NOUN
admet-2214	484	61	varlet	varlet	NOUN
admet-2214	484	62	,	,	PUNCT
admet-2214	484	63	m.a	m.a	PROPN
admet-2214	484	64	.	.	PROPN
admet-2214	484	65	debily	debily	PROPN
admet-2214	484	66	.	.	PUNCT
admet-2214	485	1	histone	histone	NOUN
admet-2214	485	2	h3f3a	h3f3a	PUNCT
admet-2214	485	3	and	and	CCONJ
admet-2214	485	4	hist1h3b	hist1h3b	PRON
admet-2214	485	5	k27	k27	PROPN
admet-2214	485	6	m	m	PROPN
admet-2214	485	7	mutations	mutation	NOUN
admet-2214	485	8	define	define	VERB
admet-2214	485	9	two	two	NUM
admet-2214	485	10	subgroups	subgroup	NOUN
admet-2214	485	11	of	of	ADP
admet-2214	485	12	diffuse	diffuse	NOUN
admet-2214	485	13	intrinsic	intrinsic	ADJ
admet-2214	485	14	pontine	pontine	ADJ
admet-2214	485	15	gliomas	glioma	NOUN
admet-2214	485	16	with	with	ADP
admet-2214	485	17	different	different	ADJ
admet-2214	485	18	prognosis	prognosis	NOUN
admet-2214	485	19	and	and	CCONJ
admet-2214	485	20	phenotypes	phenotype	NOUN
admet-2214	485	21	.	.	PUNCT
admet-2214	486	1	acta	acta	PROPN
admet-2214	486	2	neuropathologica	neuropathologica	PROPN
admet-2214	486	3	130	130	NUM
admet-2214	486	4	(	(	PUNCT
admet-2214	486	5	2015	2015	NUM
admet-2214	486	6	)	)	PUNCT
admet-2214	486	7	815	815	NUM
admet-2214	486	8	-	-	SYM
admet-2214	486	9	827	827	NUM
admet-2214	486	10	.	.	PUNCT
admet-2214	487	1	https://doi.org/10.1007/s00401-015-1478-0	https://doi.org/10.1007/s00401-015-1478-0	NUM
admet-2214	488	1	[	[	X
admet-2214	488	2	20	20	NUM
admet-2214	488	3	]	]	X
admet-2214	488	4	d.a	d.a	PROPN
admet-2214	488	5	.	.	PROPN
admet-2214	488	6	khuong	khuong	PROPN
admet-2214	488	7	-	-	PUNCT
admet-2214	488	8	quang	quang	PROPN
admet-2214	488	9	,	,	PUNCT
admet-2214	488	10	p.	p.	NOUN
admet-2214	488	11	buczkowicz	buczkowicz	NOUN
admet-2214	488	12	,	,	PUNCT
admet-2214	488	13	p.	p.	PROPN
admet-2214	488	14	rakopoulos	rakopoulos	PROPN
admet-2214	488	15	,	,	PUNCT
admet-2214	488	16	x.y	x.y	PROPN
admet-2214	488	17	.	.	PROPN
admet-2214	488	18	liu	liu	PROPN
admet-2214	488	19	,	,	PUNCT
admet-2214	488	20	a.m.	a.m.	PROPN
admet-2214	488	21	fontebasso	fontebasso	PROPN
admet-2214	488	22	,	,	PUNCT
admet-2214	488	23	e.	e.	PROPN
admet-2214	488	24	bouffet	bouffet	PROPN
admet-2214	488	25	,	,	PUNCT
admet-2214	488	26	u.	u.	PROPN
admet-2214	488	27	bartels	bartels	PROPN
admet-2214	488	28	,	,	PUNCT
admet-2214	488	29	s.	s.	PROPN
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admet-2214	488	31	,	,	PUNCT
admet-2214	488	32	j.	j.	PROPN
admet-2214	488	33	schwartzentruber	schwartzentruber	PROPN
admet-2214	488	34	,	,	PUNCT
admet-2214	488	35	l.	l.	PROPN
admet-2214	488	36	letourneau	letourneau	PROPN
admet-2214	488	37	,	,	PUNCT
admet-2214	488	38	m.	m.	NOUN
admet-2214	488	39	bourgey	bourgey	PROPN
admet-2214	488	40	,	,	PUNCT
admet-2214	488	41	g.	g.	PROPN
admet-2214	488	42	bourque	bourque	PROPN
admet-2214	488	43	,	,	PUNCT
admet-2214	488	44	a.	a.	PROPN
admet-2214	488	45	montpetit	montpetit	PROPN
admet-2214	488	46	,	,	PUNCT
admet-2214	488	47	g.	g.	PROPN
admet-2214	488	48	bourret	bourret	PROPN
admet-2214	488	49	,	,	PUNCT
admet-2214	488	50	p.	p.	NOUN
admet-2214	488	51	lepage	lepage	NOUN
admet-2214	488	52	,	,	PUNCT
admet-2214	488	53	a.	a.	NOUN
admet-2214	488	54	fleming	fleming	PROPN
admet-2214	488	55	,	,	PUNCT
admet-2214	488	56	p.	p.	PROPN
admet-2214	488	57	lichter	lichter	PROPN
admet-2214	488	58	,	,	PUNCT
admet-2214	488	59	m.	m.	NOUN
admet-2214	488	60	kool	kool	PROPN
admet-2214	488	61	,	,	PUNCT
admet-2214	488	62	a.	a.	PROPN
admet-2214	488	63	von	von	PROPN
admet-2214	488	64	deimling	deimling	PROPN
admet-2214	488	65	,	,	PUNCT
admet-2214	488	66	d.	d.	PROPN
admet-2214	488	67	sturm	sturm	PROPN
admet-2214	488	68	,	,	PUNCT
admet-2214	488	69	a.	a.	PROPN
admet-2214	488	70	korshunov	korshunov	PROPN
admet-2214	488	71	,	,	PUNCT
admet-2214	488	72	d.	d.	PROPN
admet-2214	488	73	faury	faury	PROPN
admet-2214	488	74	,	,	PUNCT
admet-2214	488	75	d.t	d.t	PROPN
admet-2214	488	76	.	.	PROPN
admet-2214	488	77	jones	jones	PROPN
admet-2214	488	78	,	,	PUNCT
admet-2214	488	79	j.	j.	PROPN
admet-2214	488	80	majewski	majewski	PROPN
admet-2214	488	81	,	,	PUNCT
admet-2214	488	82	s.m	s.m	PROPN
admet-2214	488	83	.	.	PROPN
admet-2214	488	84	pfister	pfister	PROPN
admet-2214	488	85	,	,	PUNCT
admet-2214	488	86	n.	n.	PROPN
admet-2214	488	87	jabado	jabado	NOUN
admet-2214	488	88	,	,	PUNCT
admet-2214	488	89	c.	c.	PROPN
admet-2214	488	90	hawkins	hawkins	PROPN
admet-2214	488	91	.	.	PUNCT
admet-2214	489	1	k27	k27	PROPN
admet-2214	489	2	m	m	PROPN
admet-2214	489	3	mutation	mutation	NOUN
admet-2214	489	4	in	in	ADP
admet-2214	489	5	histone	histone	NOUN
admet-2214	489	6	h3.3	h3.3	NOUN
admet-2214	489	7	defines	define	NOUN
admet-2214	489	8	clinically	clinically	ADV
admet-2214	489	9	and	and	CCONJ
admet-2214	489	10	biologically	biologically	ADV
admet-2214	489	11	distinct	distinct	ADJ
admet-2214	489	12	subgroups	subgroup	NOUN
admet-2214	489	13	of	of	ADP
admet-2214	489	14	pediatric	pediatric	ADJ
admet-2214	489	15	diffuse	diffuse	NOUN
admet-2214	489	16	intrinsic	intrinsic	ADJ
admet-2214	489	17	pontine	pontine	ADJ
admet-2214	489	18	gliomas	glioma	NOUN
admet-2214	489	19	.	.	PUNCT
admet-2214	490	1	acta	acta	PROPN
admet-2214	490	2	neuropathologica	neuropathologica	PROPN
admet-2214	490	3	124	124	NUM
admet-2214	490	4	(	(	PUNCT
admet-2214	490	5	2012	2012	NUM
admet-2214	490	6	)	)	PUNCT
admet-2214	490	7	439	439	NUM
admet-2214	490	8	-	-	SYM
admet-2214	490	9	447	447	NUM
admet-2214	490	10	https://doi.org/10.1007/s00401-012-0998-0	https://doi.org/10.1007/s00401-012-0998-0	NUM
admet-2214	491	1	[	[	X
admet-2214	491	2	21	21	NUM
admet-2214	491	3	]	]	X
admet-2214	491	4	c.	c.	PROPN
admet-2214	491	5	jones	jones	PROPN
admet-2214	491	6	,	,	PUNCT
admet-2214	491	7	s.j	s.j	PROPN
admet-2214	491	8	.	.	PROPN
admet-2214	491	9	baker	baker	PROPN
admet-2214	491	10	.	.	PUNCT
admet-2214	492	1	unique	unique	ADJ
admet-2214	492	2	genetic	genetic	ADJ
admet-2214	492	3	and	and	CCONJ
admet-2214	492	4	epigenetic	epigenetic	ADJ
admet-2214	492	5	mechanisms	mechanism	NOUN
admet-2214	492	6	driving	drive	VERB
admet-2214	492	7	paediatric	paediatric	ADJ
admet-2214	492	8	diffuse	diffuse	NOUN
admet-2214	492	9	highgrade	highgrade	NOUN
admet-2214	492	10	glioma	glioma	NOUN
admet-2214	492	11	.	.	PUNCT
admet-2214	493	1	nature	nature	NOUN
admet-2214	493	2	reviews	review	VERB
admet-2214	493	3	cancer	cancer	NOUN
admet-2214	493	4	14	14	NUM
admet-2214	493	5	(	(	PUNCT
admet-2214	493	6	2014	2014	NUM
admet-2214	493	7	)	)	PUNCT
admet-2214	493	8	651	651	NUM
admet-2214	493	9	-	-	SYM
admet-2214	493	10	661	661	NUM
admet-2214	493	11	.	.	PUNCT
admet-2214	494	1	https://doi.org/10.1038/nrc3811	https://doi.org/10.1038/nrc3811	PRON
admet-2214	495	1	[	[	X
admet-2214	495	2	22	22	NUM
admet-2214	495	3	]	]	X
admet-2214	495	4	c.s	c.s	PROPN
admet-2214	495	5	.	.	PROPN
admet-2214	495	6	grasso	grasso	PROPN
admet-2214	495	7	,	,	PUNCT
admet-2214	495	8	y.	y.	PROPN
admet-2214	495	9	tang	tang	PROPN
admet-2214	495	10	,	,	PUNCT
admet-2214	495	11	n.	n.	PROPN
admet-2214	495	12	truffaux	truffaux	PROPN
admet-2214	495	13	,	,	PUNCT
admet-2214	495	14	n.e	n.e	PROPN
admet-2214	495	15	.	.	PROPN
admet-2214	495	16	berlow	berlow	PROPN
admet-2214	495	17	,	,	PUNCT
admet-2214	495	18	l.	l.	PROPN
admet-2214	495	19	liu	liu	PROPN
admet-2214	495	20	,	,	PUNCT
admet-2214	495	21	m.a	m.a	PROPN
admet-2214	495	22	.	.	PROPN
admet-2214	495	23	debily	debily	PROPN
admet-2214	495	24	,	,	PUNCT
admet-2214	495	25	m.j	m.j	PROPN
admet-2214	495	26	.	.	PROPN
admet-2214	495	27	quist	quist	PROPN
admet-2214	495	28	,	,	PUNCT
admet-2214	495	29	l.e	l.e	PROPN
admet-2214	495	30	.	.	PROPN
admet-2214	495	31	davis	davis	PROPN
admet-2214	495	32	,	,	PUNCT
admet-2214	495	33	e.c	e.c	PROPN
admet-2214	495	34	.	.	PROPN
admet-2214	495	35	huang	huang	PROPN
admet-2214	495	36	,	,	PUNCT
admet-2214	495	37	p.j	p.j	PROPN
admet-2214	495	38	.	.	PROPN
admet-2214	495	39	woo	woo	PROPN
admet-2214	495	40	,	,	PUNCT
admet-2214	495	41	a.	a.	NOUN
admet-2214	495	42	ponnuswami	ponnuswami	NOUN
admet-2214	495	43	,	,	PUNCT
admet-2214	495	44	s.	s.	PROPN
admet-2214	495	45	chen	chen	PROPN
admet-2214	495	46	,	,	PUNCT
admet-2214	495	47	t.b	t.b	PROPN
admet-2214	495	48	.	.	PROPN
admet-2214	495	49	johung	johung	PROPN
admet-2214	495	50	,	,	PUNCT
admet-2214	495	51	w.	w.	PROPN
admet-2214	495	52	sun	sun	PROPN
admet-2214	495	53	,	,	PUNCT
admet-2214	495	54	m.	m.	NOUN
admet-2214	495	55	kogiso	kogiso	PROPN
admet-2214	495	56	,	,	PUNCT
admet-2214	495	57	y.	y.	PROPN
admet-2214	495	58	du	du	PROPN
admet-2214	495	59	,	,	PUNCT
admet-2214	495	60	l.	l.	PROPN
admet-2214	495	61	qi	qi	PROPN
admet-2214	495	62	,	,	PUNCT
admet-2214	495	63	y.	y.	PROPN
admet-2214	495	64	huang	huang	PROPN
admet-2214	495	65	,	,	PUNCT
admet-2214	495	66	m.	m.	NOUN
admet-2214	495	67	hüttcabezas	hüttcabezas	PROPN
admet-2214	495	68	,	,	PUNCT
admet-2214	495	69	k.e	k.e	PROPN
admet-2214	495	70	.	.	PROPN
admet-2214	495	71	warren	warren	PROPN
admet-2214	495	72	,	,	PUNCT
admet-2214	495	73	l.	l.	PROPN
admet-2214	495	74	le	le	PROPN
admet-2214	495	75	dret	dret	PROPN
admet-2214	495	76	,	,	PUNCT
admet-2214	495	77	p.s	p.s	PROPN
admet-2214	495	78	.	.	PROPN
admet-2214	495	79	meltzer	meltzer	PROPN
admet-2214	495	80	,	,	PUNCT
admet-2214	495	81	h.	h.	PROPN
admet-2214	495	82	mao	mao	PROPN
admet-2214	495	83	,	,	PUNCT
admet-2214	495	84	m.	m.	NOUN
admet-2214	495	85	quezado	quezado	PROPN
admet-2214	495	86	,	,	PUNCT
admet-2214	495	87	d.g	d.g	PROPN
admet-2214	495	88	.	.	PROPN
admet-2214	495	89	van	van	PROPN
admet-2214	495	90	vuurden	vuurden	PROPN
admet-2214	495	91	,	,	PUNCT
admet-2214	495	92	j.	j.	PROPN
admet-2214	495	93	abraham	abraham	PROPN
admet-2214	495	94	,	,	PUNCT
admet-2214	495	95	m.	m.	NOUN
admet-2214	495	96	fouladi	fouladi	NOUN
admet-2214	495	97	,	,	PUNCT
admet-2214	495	98	m.n	m.n	PROPN
admet-2214	495	99	.	.	PROPN
admet-2214	495	100	svalina	svalina	NOUN
admet-2214	495	101	,	,	PUNCT
admet-2214	495	102	n.	n.	PROPN
admet-2214	495	103	wang	wang	PROPN
admet-2214	495	104	,	,	PUNCT
admet-2214	495	105	c.	c.	PROPN
admet-2214	495	106	hawkins	hawkins	PROPN
admet-2214	495	107	,	,	PUNCT
admet-2214	495	108	j.	j.	PROPN
admet-2214	495	109	nazarian	nazarian	PROPN
admet-2214	495	110	,	,	PUNCT
admet-2214	495	111	m.m	m.m	PROPN
admet-2214	495	112	.	.	PROPN
admet-2214	495	113	alonso	alonso	PROPN
admet-2214	495	114	,	,	PUNCT
admet-2214	495	115	e.h	e.h	PROPN
admet-2214	495	116	.	.	PROPN
admet-2214	495	117	raabe	raabe	PROPN
admet-2214	495	118	,	,	PUNCT
admet-2214	495	119	e.	e.	PROPN
admet-2214	495	120	hulleman	hulleman	PROPN
admet-2214	495	121	,	,	PUNCT
admet-2214	495	122	p.t	p.t	PROPN
admet-2214	495	123	.	.	PROPN
admet-2214	495	124	spellman	spellman	PROPN
admet-2214	495	125	,	,	PUNCT
admet-2214	495	126	x.n	x.n	PROPN
admet-2214	495	127	.	.	PUNCT
admet-2214	495	128	li	li	PROPN
admet-2214	495	129	,	,	PUNCT
admet-2214	495	130	c.	c.	PROPN
admet-2214	495	131	keller	keller	PROPN
admet-2214	495	132	,	,	PUNCT
admet-2214	495	133	r.	r.	PROPN
admet-2214	495	134	pal	pal	PROPN
admet-2214	495	135	,	,	PUNCT
admet-2214	495	136	j.	j.	PROPN
admet-2214	495	137	grill	grill	PROPN
admet-2214	495	138	,	,	PUNCT
admet-2214	495	139	m.	m.	NOUN
admet-2214	495	140	monje	monje	PROPN
admet-2214	495	141	.	.	PUNCT
admet-2214	496	1	functionally	functionally	ADV
admet-2214	496	2	defined	define	VERB
admet-2214	496	3	therapeutic	therapeutic	ADJ
admet-2214	496	4	targets	target	NOUN
admet-2214	496	5	in	in	ADP
admet-2214	496	6	diffuse	diffuse	ADJ
admet-2214	496	7	intrinsic	intrinsic	ADJ
admet-2214	496	8	pontine	pontine	ADJ
admet-2214	496	9	glioma	glioma	NOUN
admet-2214	496	10	.	.	PUNCT
admet-2214	497	1	nature	nature	NOUN
admet-2214	497	2	medicine	medicine	NOUN
admet-2214	497	3	21	21	NUM
admet-2214	497	4	(	(	PUNCT
admet-2214	497	5	2015	2015	NUM
admet-2214	497	6	)	)	PUNCT
admet-2214	497	7	555	555	NUM
admet-2214	497	8	-	-	SYM
admet-2214	497	9	559	559	NUM
admet-2214	497	10	https://doi.org/10.1038/nm.3855	https://doi.org/10.1038/nm.3855	PROPN
admet-2214	498	1	[	[	X
admet-2214	498	2	23	23	NUM
admet-2214	498	3	]	]	X
admet-2214	498	4	p.f	p.f	PROPN
admet-2214	498	5	.	.	PROPN
admet-2214	498	6	recinos	recinos	PROPN
admet-2214	498	7	,	,	PUNCT
admet-2214	498	8	d.m	d.m	PROPN
admet-2214	498	9	.	.	PROPN
admet-2214	498	10	sciubba	sciubba	PROPN
admet-2214	498	11	,	,	PUNCT
admet-2214	498	12	g.i	g.i	PROPN
admet-2214	498	13	.	.	PROPN
admet-2214	498	14	jallo	jallo	PROPN
admet-2214	498	15	.	.	PUNCT
admet-2214	499	1	brainstem	brainstem	NOUN
admet-2214	499	2	tumors	tumor	NOUN
admet-2214	499	3	:	:	PUNCT
admet-2214	499	4	where	where	SCONJ
admet-2214	499	5	are	be	AUX
admet-2214	499	6	we	we	PRON
admet-2214	499	7	today	today	NOUN
admet-2214	499	8	?	?	PUNCT
admet-2214	500	1	pediatric	pediatric	ADJ
admet-2214	500	2	neurosurgery	neurosurgery	NOUN
admet-2214	500	3	43	43	NUM
admet-2214	500	4	(	(	PUNCT
admet-2214	500	5	2007	2007	NUM
admet-2214	500	6	)	)	PUNCT
admet-2214	500	7	192	192	NUM
admet-2214	500	8	-	-	SYM
admet-2214	500	9	201	201	NUM
admet-2214	500	10	.	.	PUNCT
admet-2214	500	11	https://doi.org/10.1159/000098831	https://doi.org/10.1159/000098831	X
admet-2214	501	1	[	[	X
admet-2214	501	2	24	24	NUM
admet-2214	501	3	]	]	PUNCT
admet-2214	501	4	a.	a.	NOUN
admet-2214	501	5	perry	perry	PROPN
admet-2214	501	6	,	,	PUNCT
admet-2214	501	7	c.r	c.r	PROPN
admet-2214	501	8	.	.	PROPN
admet-2214	501	9	miller	miller	PROPN
admet-2214	501	10	,	,	PUNCT
admet-2214	501	11	m.	m.	NOUN
admet-2214	501	12	gujrati	gujrati	PROPN
admet-2214	501	13	,	,	PUNCT
admet-2214	501	14	b.w	b.w	PROPN
admet-2214	501	15	.	.	PROPN
admet-2214	501	16	scheithauer	scheithauer	PROPN
admet-2214	501	17	,	,	PUNCT
admet-2214	501	18	s.c	s.c	PROPN
admet-2214	501	19	.	.	PROPN
admet-2214	501	20	zambrano	zambrano	PROPN
admet-2214	501	21	,	,	PUNCT
admet-2214	501	22	s.c	s.c	PROPN
admet-2214	501	23	.	.	PROPN
admet-2214	501	24	jost	jost	PROPN
admet-2214	501	25	,	,	PUNCT
admet-2214	501	26	r.	r.	PROPN
admet-2214	501	27	raghavan	raghavan	PROPN
admet-2214	501	28	,	,	PUNCT
admet-2214	501	29	j.	j.	PROPN
admet-2214	501	30	qian	qian	PROPN
admet-2214	501	31	,	,	PUNCT
admet-2214	501	32	e.j	e.j	PROPN
admet-2214	501	33	.	.	PROPN
admet-2214	501	34	cochran	cochran	PROPN
admet-2214	501	35	,	,	PUNCT
admet-2214	501	36	j.t	j.t	PROPN
admet-2214	501	37	.	.	PROPN
admet-2214	501	38	huse	huse	PROPN
admet-2214	501	39	,	,	PUNCT
admet-2214	501	40	e.c	e.c	PROPN
admet-2214	501	41	.	.	PROPN
admet-2214	501	42	holland	holland	PROPN
admet-2214	501	43	,	,	PUNCT
admet-2214	501	44	p.c	p.c	PROPN
admet-2214	501	45	.	.	PROPN
admet-2214	501	46	burger	burger	PROPN
admet-2214	501	47	,	,	PUNCT
admet-2214	501	48	m.k	m.k	PROPN
admet-2214	501	49	.	.	PROPN
admet-2214	501	50	rosenblum	rosenblum	PROPN
admet-2214	501	51	.	.	PUNCT
admet-2214	502	1	malignant	malignant	ADJ
admet-2214	502	2	gliomas	glioma	NOUN
admet-2214	502	3	with	with	ADP
admet-2214	502	4	primitive	primitive	ADJ
admet-2214	502	5	neuroectodermal	neuroectodermal	ADJ
admet-2214	502	6	tumor	tumor	NOUN
admet-2214	502	7	-	-	PUNCT
admet-2214	502	8	like	like	ADJ
admet-2214	502	9	components	component	NOUN
admet-2214	502	10	:	:	PUNCT
admet-2214	502	11	a	a	DET
admet-2214	502	12	clinicopathologic	clinicopathologic	ADJ
admet-2214	502	13	and	and	CCONJ
admet-2214	502	14	genetic	genetic	ADJ
admet-2214	502	15	study	study	NOUN
admet-2214	502	16	of	of	ADP
admet-2214	502	17	53	53	NUM
admet-2214	502	18	cases	case	NOUN
admet-2214	502	19	.	.	PUNCT
admet-2214	503	1	brain	brain	NOUN
admet-2214	503	2	pathology	pathology	NOUN
admet-2214	503	3	19	19	NUM
admet-2214	503	4	(	(	PUNCT
admet-2214	503	5	2009	2009	NUM
admet-2214	503	6	)	)	PUNCT
admet-2214	503	7	81	81	NUM
admet-2214	503	8	-	-	SYM
admet-2214	503	9	90	90	NUM
admet-2214	503	10	.	.	PUNCT
admet-2214	504	1	https://doi.org/10.1111/j.1750-3639.2008.00167.x	https://doi.org/10.1111/j.1750-3639.2008.00167.x	NOUN
admet-2214	505	1	[	[	X
admet-2214	505	2	25	25	NUM
admet-2214	505	3	]	]	PUNCT
admet-2214	505	4	a.a	a.a	PROPN
admet-2214	505	5	.	.	PROPN
admet-2214	505	6	yetisgin	yetisgin	PROPN
admet-2214	505	7	,	,	PUNCT
admet-2214	505	8	s.	s.	PROPN
admet-2214	505	9	cetinel	cetinel	PROPN
admet-2214	505	10	,	,	PUNCT
admet-2214	505	11	m.	m.	NOUN
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admet-2214	505	16	,	,	PUNCT
admet-2214	505	17	o.	o.	PROPN
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admet-2214	505	19	.	.	PUNCT
admet-2214	506	1	therapeutic	therapeutic	ADJ
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admet-2214	506	3	and	and	CCONJ
admet-2214	506	4	their	their	PRON
admet-2214	506	5	targeted	target	VERB
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admet-2214	506	7	applications	application	NOUN
admet-2214	506	8	.	.	PUNCT
admet-2214	507	1	molecules	molecule	NOUN
admet-2214	507	2	25(9	25(9	NUM
admet-2214	507	3	)	)	PUNCT
admet-2214	507	4	(	(	PUNCT
admet-2214	507	5	2020	2020	NUM
admet-2214	507	6	)	)	PUNCT
admet-2214	507	7	2193	2193	NUM
admet-2214	507	8	.	.	PUNCT
admet-2214	508	1	https://doi.org/10.3390/molecules25092193	https://doi.org/10.3390/molecules25092193	PROPN
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admet-2214	509	2	26	26	NUM
admet-2214	509	3	]	]	X
admet-2214	509	4	r.s	r.s	PROPN
admet-2214	509	5	.	.	PUNCT
admet-2214	509	6	kadam	kadam	PROPN
admet-2214	509	7	,	,	PUNCT
admet-2214	509	8	d.w.a	d.w.a	PROPN
admet-2214	509	9	.	.	PUNCT
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admet-2214	509	15	.	.	PUNCT
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admet-2214	510	2	-	-	PUNCT
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admet-2214	510	7	delivery	delivery	NOUN
admet-2214	510	8	with	with	ADP
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admet-2214	510	10	nanoparticles	nanoparticle	NOUN
admet-2214	510	11	:	:	PUNCT
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admet-2214	510	16	.	.	PUNCT
admet-2214	511	1	drug	drug	NOUN
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admet-2214	511	6	(	(	PUNCT
admet-2214	511	7	2012	2012	NUM
admet-2214	511	8	)	)	PUNCT
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admet-2214	511	10	-	-	SYM
admet-2214	511	11	1388	1388	NUM
admet-2214	511	12	.	.	PUNCT
admet-2214	512	1	https://doi.org/10.1124/dmd.112.044925	https://doi.org/10.1124/dmd.112.044925	ADJ
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admet-2214	512	8	,	,	PUNCT
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admet-2214	512	10	.	.	PUNCT
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admet-2214	512	12	,	,	PUNCT
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admet-2214	512	15	,	,	PUNCT
admet-2214	512	16	a.	a.	NOUN
admet-2214	512	17	haddadi	haddadi	PROPN
admet-2214	512	18	.	.	PUNCT
admet-2214	513	1	targeted	target	VERB
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admet-2214	513	4	:	:	PUNCT
admet-2214	513	5	an	an	DET
admet-2214	513	6	immense	immense	ADJ
admet-2214	513	7	promise	promise	NOUN
admet-2214	513	8	to	to	PART
admet-2214	513	9	fight	fight	VERB
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admet-2214	513	12	.	.	PUNCT
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admet-2214	514	4	delivery	delivery	NOUN
admet-2214	514	5	2017	2017	NUM
admet-2214	514	6	(	(	PUNCT
admet-2214	514	7	2017	2017	NUM
admet-2214	514	8	)	)	PUNCT
admet-2214	514	9	9090325	9090325	NUM
admet-2214	514	10	.	.	PUNCT
admet-2214	515	1	https://doi.org/10.1155/2017/9090325	https://doi.org/10.1155/2017/9090325	PROPN
admet-2214	516	1	[	[	X
admet-2214	516	2	28	28	NUM
admet-2214	516	3	]	]	X
admet-2214	516	4	s.	s.	PROPN
admet-2214	516	5	chandrasekhar	chandrasekhar	PROPN
admet-2214	516	6	,	,	PUNCT
admet-2214	516	7	l.k	l.k	PROPN
admet-2214	516	8	.	.	PROPN
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admet-2214	516	10	,	,	PUNCT
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admet-2214	516	12	.	.	PROPN
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admet-2214	516	14	,	,	PUNCT
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admet-2214	516	16	.	.	PROPN
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admet-2214	516	18	,	,	PUNCT
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admet-2214	516	20	.	.	PUNCT
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admet-2214	516	22	,	,	PUNCT
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admet-2214	516	26	.	.	PUNCT
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admet-2214	517	7	of	of	ADP
admet-2214	517	8	peptides	peptide	NOUN
admet-2214	517	9	,	,	PUNCT
admet-2214	517	10	proteins	protein	NOUN
admet-2214	517	11	,	,	PUNCT
admet-2214	517	12	vaccines	vaccine	NOUN
admet-2214	517	13	and	and	CCONJ
admet-2214	517	14	other	other	ADJ
admet-2214	517	15	applications	application	NOUN
admet-2214	517	16	.	.	PUNCT
admet-2214	518	1	expert	expert	ADJ
admet-2214	518	2	opinion	opinion	NOUN
admet-2214	518	3	on	on	ADP
admet-2214	518	4	drug	drug	NOUN
admet-2214	518	5	delivery	delivery	NOUN
admet-2214	518	6	10	10	NUM
admet-2214	518	7	(	(	PUNCT
admet-2214	518	8	2013	2013	NUM
admet-2214	518	9	)	)	PUNCT
admet-2214	518	10	1155	1155	NUM
admet-2214	518	11	-	-	SYM
admet-2214	518	12	1170	1170	NUM
admet-2214	518	13	.	.	PUNCT
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admet-2214	520	2	29	29	NUM
admet-2214	520	3	]	]	PUNCT
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admet-2214	520	5	rabl	rabl	PROPN
admet-2214	520	6	,	,	PUNCT
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admet-2214	520	8	.	.	PROPN
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admet-2214	520	10	,	,	PUNCT
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admet-2214	520	12	.	.	PUNCT
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admet-2214	520	14	,	,	PUNCT
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admet-2214	520	19	p.	p.	PROPN
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admet-2214	520	25	.	.	PUNCT
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admet-2214	521	3	spin	spin	NOUN
admet-2214	521	4	transducer	transducer	NOUN
admet-2214	521	5	based	base	VERB
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admet-2214	521	10	.	.	PUNCT
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admet-2214	522	4	(	(	PUNCT
admet-2214	522	5	2010	2010	NUM
admet-2214	522	6	)	)	PUNCT
admet-2214	522	7	602	602	NUM
admet-2214	522	8	-	-	SYM
admet-2214	522	9	608	608	NUM
admet-2214	522	10	.	.	PUNCT
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admet-2214	523	3	30	30	NUM
admet-2214	523	4	]	]	X
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admet-2214	523	8	,	,	PUNCT
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admet-2214	523	22	.	.	PUNCT
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admet-2214	524	5	-	-	PUNCT
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admet-2214	524	9	.	.	PUNCT
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admet-2214	525	7	8(5	8(5	NUM
admet-2214	525	8	)	)	PUNCT
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admet-2214	525	11	)	)	PUNCT
admet-2214	525	12	605	605	NUM
admet-2214	525	13	-	-	SYM
admet-2214	525	14	609	609	NUM
admet-2214	525	15	.	.	PUNCT
admet-2214	526	1	https://www.jocpr.com/articles/therapeutic-applications-of-nanorobotsrespirocytes-and-microbivores.pdf	https://www.jocpr.com/articles/therapeutic-applications-of-nanorobotsrespirocytes-and-microbivores.pdf	PROPN
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admet-2214	527	3	]	]	PUNCT
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admet-2214	528	4	:	:	PUNCT
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admet-2214	528	13	.	.	PUNCT
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admet-2214	529	7	(	(	PUNCT
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admet-2214	529	9	)	)	PUNCT
admet-2214	529	10	25	25	NUM
admet-2214	529	11	.	.	PUNCT
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admet-2214	530	6	https://doi.org/10.1007/s00401-012-0998-0	https://doi.org/10.1007/s00401-012-0998-0	NUM
admet-2214	530	7	https://doi.org/10.1038/nrc3811	https://doi.org/10.1038/nrc3811	NUM
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admet-2214	531	3	https://www.jocpr.com/articles/therapeutic-applications-of-nanorobots-respirocytes-and-microbivores.pdf	https://www.jocpr.com/articles/therapeutic-applications-of-nanorobots-respirocytes-and-microbivores.pdf	PROPN
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admet-2214	531	9	.	.	PROPN
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admet-2214	531	13	12(3	12(3	PROPN
admet-2214	531	14	)	)	PUNCT
admet-2214	531	15	(	(	PUNCT
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admet-2214	531	17	)	)	PUNCT
admet-2214	531	18	403	403	NUM
admet-2214	531	19	-	-	SYM
admet-2214	531	20	429	429	NUM
admet-2214	531	21	424	424	NUM
admet-2214	531	22	[	[	SYM
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admet-2214	531	24	]	]	PUNCT
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admet-2214	531	42	.	.	PUNCT
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admet-2214	532	10	-	-	PUNCT
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admet-2214	532	17	.	.	PUNCT
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admet-2214	533	3	controlled	control	VERB
admet-2214	533	4	release	release	NOUN
admet-2214	533	5	235	235	NUM
admet-2214	533	6	(	(	PUNCT
admet-2214	533	7	2016	2016	NUM
admet-2214	533	8	)	)	PUNCT
admet-2214	533	9	34	34	NUM
admet-2214	533	10	-	-	SYM
admet-2214	533	11	47	47	NUM
admet-2214	533	12	.	.	PUNCT
admet-2214	534	1	https://doi.org/10.1016/j.jconrel.2016.05.044	https://doi.org/10.1016/j.jconrel.2016.05.044	PROPN
admet-2214	534	2	[	[	X
admet-2214	534	3	33	33	NUM
admet-2214	534	4	]	]	SYM
admet-2214	534	5	a.b	a.b	PROPN
admet-2214	534	6	.	.	PROPN
admet-2214	534	7	etame	etame	PROPN
admet-2214	534	8	,	,	PUNCT
admet-2214	534	9	c.a	c.a	PROPN
admet-2214	534	10	.	.	PROPN
admet-2214	534	11	smith	smith	PROPN
admet-2214	534	12	,	,	PUNCT
admet-2214	534	13	w.c.w	w.c.w	PROPN
admet-2214	534	14	.	.	PUNCT
admet-2214	534	15	chan	chan	PROPN
admet-2214	534	16	,	,	PUNCT
admet-2214	534	17	j.t	j.t	PROPN
admet-2214	534	18	.	.	PROPN
admet-2214	534	19	rutka	rutka	PROPN
admet-2214	534	20	.	.	PUNCT
admet-2214	535	1	design	design	NOUN
admet-2214	535	2	and	and	CCONJ
admet-2214	535	3	potential	potential	ADJ
admet-2214	535	4	application	application	NOUN
admet-2214	535	5	of	of	ADP
admet-2214	535	6	pegylated	pegylated	ADJ
admet-2214	535	7	gold	gold	NOUN
admet-2214	535	8	nanoparticles	nanoparticle	NOUN
admet-2214	535	9	with	with	ADP
admet-2214	535	10	size	size	NOUN
admet-2214	535	11	-	-	PUNCT
admet-2214	535	12	dependent	dependent	ADJ
admet-2214	535	13	permeation	permeation	NOUN
admet-2214	535	14	through	through	ADP
admet-2214	535	15	brain	brain	NOUN
admet-2214	535	16	microvasculature	microvasculature	NOUN
admet-2214	535	17	.	.	PUNCT
admet-2214	536	1	nanomedicine	nanomedicine	NOUN
admet-2214	536	2	:	:	PUNCT
admet-2214	536	3	nanotechnology	nanotechnology	NOUN
admet-2214	536	4	,	,	PUNCT
admet-2214	536	5	biology	biology	NOUN
admet-2214	536	6	,	,	PUNCT
admet-2214	536	7	and	and	CCONJ
admet-2214	536	8	medicine	medicine	NOUN
admet-2214	536	9	7	7	NUM
admet-2214	536	10	(	(	PUNCT
admet-2214	536	11	2011	2011	NUM
admet-2214	536	12	)	)	PUNCT
admet-2214	536	13	992	992	NUM
admet-2214	536	14	-	-	SYM
admet-2214	536	15	1000	1000	NUM
admet-2214	536	16	.	.	PUNCT
admet-2214	537	1	https://doi.org/10.1016/j.nano.2011.04.004	https://doi.org/10.1016/j.nano.2011.04.004	NOUN
admet-2214	537	2	[	[	X
admet-2214	537	3	34	34	NUM
admet-2214	537	4	]	]	X
admet-2214	537	5	s.	s.	PROPN
admet-2214	537	6	hanada	hanada	PROPN
admet-2214	537	7	,	,	PUNCT
admet-2214	537	8	k.	k.	PROPN
admet-2214	537	9	fujioka	fujioka	PROPN
admet-2214	537	10	,	,	PUNCT
admet-2214	537	11	y.	y.	PROPN
admet-2214	537	12	inoue	inoue	PROPN
admet-2214	537	13	,	,	PUNCT
admet-2214	537	14	f.	f.	PROPN
admet-2214	537	15	kanaya	kanaya	PROPN
admet-2214	537	16	,	,	PUNCT
admet-2214	537	17	y.	y.	PROPN
admet-2214	537	18	manome	manome	PROPN
admet-2214	537	19	,	,	PUNCT
admet-2214	537	20	k.	k.	PROPN
admet-2214	537	21	yamamoto	yamamoto	PROPN
admet-2214	537	22	.	.	PUNCT
admet-2214	538	1	cell	cell	NOUN
admet-2214	538	2	-	-	PUNCT
admet-2214	538	3	based	base	VERB
admet-2214	538	4	in	in	ADP
admet-2214	538	5	vitro	vitro	X
admet-2214	538	6	blood	blood	NOUN
admet-2214	538	7	-	-	PUNCT
admet-2214	538	8	brain	brain	NOUN
admet-2214	538	9	barrier	barrier	NOUN
admet-2214	538	10	model	model	NOUN
admet-2214	538	11	can	can	AUX
admet-2214	538	12	rapidly	rapidly	ADV
admet-2214	538	13	evaluate	evaluate	VERB
admet-2214	538	14	nanoparticles	nanoparticle	NOUN
admet-2214	538	15	’	'	PUNCT
admet-2214	538	16	brain	brain	NOUN
admet-2214	538	17	permeability	permeability	NOUN
admet-2214	538	18	in	in	ADP
admet-2214	538	19	association	association	NOUN
admet-2214	538	20	with	with	ADP
admet-2214	538	21	particle	particle	NOUN
admet-2214	538	22	size	size	NOUN
admet-2214	538	23	and	and	CCONJ
admet-2214	538	24	surface	surface	NOUN
admet-2214	538	25	modification	modification	NOUN
admet-2214	538	26	.	.	PUNCT
admet-2214	539	1	international	international	ADJ
admet-2214	539	2	journal	journal	NOUN
admet-2214	539	3	of	of	ADP
admet-2214	539	4	molecular	molecular	ADJ
admet-2214	539	5	sciences	science	NOUN
admet-2214	539	6	15	15	NUM
admet-2214	539	7	(	(	PUNCT
admet-2214	539	8	2014	2014	NUM
admet-2214	539	9	)	)	PUNCT
admet-2214	539	10	1812	1812	NUM
admet-2214	539	11	-	-	SYM
admet-2214	539	12	1825	1825	NUM
admet-2214	539	13	.	.	PUNCT
admet-2214	540	1	https://doi.org/10.3390/ijms15021812	https://doi.org/10.3390/ijms15021812	PROPN
admet-2214	540	2	[	[	X
admet-2214	540	3	35	35	NUM
admet-2214	540	4	]	]	X
admet-2214	540	5	g.	g.	PROPN
admet-2214	540	6	sonavane	sonavane	PROPN
admet-2214	540	7	,	,	PUNCT
admet-2214	540	8	k.	k.	PROPN
admet-2214	540	9	tomoda	tomoda	PROPN
admet-2214	540	10	,	,	PUNCT
admet-2214	540	11	k.	k.	PROPN
admet-2214	540	12	makino	makino	PROPN
admet-2214	540	13	.	.	PUNCT
admet-2214	541	1	biodistribution	biodistribution	NOUN
admet-2214	541	2	of	of	ADP
admet-2214	541	3	colloidal	colloidal	NOUN
admet-2214	541	4	gold	gold	NOUN
admet-2214	541	5	nanoparticles	nanoparticle	NOUN
admet-2214	541	6	after	after	ADP
admet-2214	541	7	intravenous	intravenous	ADJ
admet-2214	541	8	administration	administration	NOUN
admet-2214	541	9	:	:	PUNCT
admet-2214	541	10	effect	effect	NOUN
admet-2214	541	11	of	of	ADP
admet-2214	541	12	particle	particle	NOUN
admet-2214	541	13	size	size	NOUN
admet-2214	541	14	.	.	PUNCT
admet-2214	542	1	colloids	colloid	NOUN
admet-2214	542	2	and	and	CCONJ
admet-2214	542	3	surfaces	surface	NOUN
admet-2214	542	4	b	b	NUM
admet-2214	542	5	:	:	PUNCT
admet-2214	542	6	biointerfaces	biointerface	NOUN
admet-2214	542	7	66	66	NUM
admet-2214	542	8	(	(	PUNCT
admet-2214	542	9	2008	2008	NUM
admet-2214	542	10	)	)	PUNCT
admet-2214	542	11	274	274	NUM
admet-2214	542	12	-	-	SYM
admet-2214	542	13	280	280	NUM
admet-2214	542	14	.	.	PUNCT
admet-2214	543	1	https://doi.org/10.1016/j.colsurfb.2008.07.004	https://doi.org/10.1016/j.colsurfb.2008.07.004	X
admet-2214	543	2	[	[	X
admet-2214	543	3	36	36	NUM
admet-2214	543	4	]	]	X
admet-2214	543	5	p.r	p.r	PROPN
admet-2214	543	6	.	.	PROPN
admet-2214	543	7	lockman	lockman	PROPN
admet-2214	543	8	,	,	PUNCT
admet-2214	543	9	j.m	j.m	PROPN
admet-2214	543	10	.	.	PROPN
admet-2214	543	11	koziara	koziara	PROPN
admet-2214	543	12	,	,	PUNCT
admet-2214	543	13	r.j	r.j	PROPN
admet-2214	543	14	.	.	PROPN
admet-2214	543	15	mumper	mumper	PROPN
admet-2214	543	16	,	,	PUNCT
admet-2214	543	17	d.	d.	PROPN
admet-2214	543	18	allen	allen	PROPN
admet-2214	543	19	.	.	PROPN
admet-2214	544	1	nanoparticle	nanoparticle	PROPN
admet-2214	544	2	surface	surface	NOUN
admet-2214	544	3	charges	charge	NOUN
admet-2214	544	4	alter	alter	VERB
admet-2214	544	5	blood	blood	NOUN
admet-2214	544	6	-	-	PUNCT
admet-2214	544	7	brain	brain	NOUN
admet-2214	544	8	barrier	barrier	NOUN
admet-2214	544	9	integrity	integrity	NOUN
admet-2214	544	10	and	and	CCONJ
admet-2214	544	11	permeability	permeability	NOUN
admet-2214	544	12	.	.	PUNCT
admet-2214	545	1	journal	journal	PROPN
admet-2214	545	2	of	of	ADP
admet-2214	545	3	drug	drug	NOUN
admet-2214	545	4	targeting	target	VERB
admet-2214	545	5	12	12	NUM
admet-2214	545	6	(	(	PUNCT
admet-2214	545	7	2004	2004	NUM
admet-2214	545	8	)	)	PUNCT
admet-2214	545	9	635	635	NUM
admet-2214	545	10	-	-	SYM
admet-2214	545	11	641	641	NUM
admet-2214	545	12	https://doi.org/10.1080/10611860400015936	https://doi.org/10.1080/10611860400015936	NOUN
admet-2214	545	13	[	[	X
admet-2214	545	14	37	37	NUM
admet-2214	545	15	]	]	PUNCT
admet-2214	545	16	x.	x.	PROPN
admet-2214	545	17	huang	huang	PROPN
admet-2214	545	18	,	,	PUNCT
admet-2214	545	19	l.	l.	PROPN
admet-2214	545	20	li	li	PROPN
admet-2214	545	21	,	,	PUNCT
admet-2214	545	22	t.	t.	PROPN
admet-2214	545	23	liu	liu	PROPN
admet-2214	545	24	,	,	PUNCT
admet-2214	545	25	n.	n.	PROPN
admet-2214	545	26	hao	hao	PROPN
admet-2214	545	27	,	,	PUNCT
admet-2214	545	28	h.	h.	PROPN
admet-2214	545	29	liu	liu	PROPN
admet-2214	545	30	,	,	PUNCT
admet-2214	545	31	d.	d.	PROPN
admet-2214	545	32	chen	chen	PROPN
admet-2214	545	33	,	,	PUNCT
admet-2214	545	34	f.	f.	PROPN
admet-2214	545	35	tang	tang	PROPN
admet-2214	545	36	.	.	PUNCT
admet-2214	546	1	the	the	DET
admet-2214	546	2	shape	shape	NOUN
admet-2214	546	3	effect	effect	NOUN
admet-2214	546	4	of	of	ADP
admet-2214	546	5	mesoporous	mesoporous	ADJ
admet-2214	546	6	silica	silica	NOUN
admet-2214	546	7	nanoparticles	nanoparticle	NOUN
admet-2214	546	8	on	on	ADP
admet-2214	546	9	biodistribution	biodistribution	NOUN
admet-2214	546	10	,	,	PUNCT
admet-2214	546	11	clearance	clearance	NOUN
admet-2214	546	12	,	,	PUNCT
admet-2214	546	13	and	and	CCONJ
admet-2214	546	14	biocompatibility	biocompatibility	NOUN
admet-2214	546	15	in	in	ADP
admet-2214	546	16	vivo	vivo	NOUN
admet-2214	546	17	.	.	PUNCT
admet-2214	547	1	acs	acs	PROPN
admet-2214	547	2	nano	nano	VERB
admet-2214	547	3	5	5	NUM
admet-2214	547	4	(	(	PUNCT
admet-2214	547	5	2011	2011	NUM
admet-2214	547	6	)	)	PUNCT
admet-2214	547	7	53905399	53905399	NUM
admet-2214	547	8	.	.	PUNCT
admet-2214	548	1	https://doi.org/10.1021/nn200365a	https://doi.org/10.1021/nn200365a	NOUN
admet-2214	549	1	[	[	X
admet-2214	549	2	38	38	NUM
admet-2214	549	3	]	]	PUNCT
admet-2214	549	4	j.	j.	PROPN
admet-2214	549	5	kreuter	kreuter	PROPN
admet-2214	549	6	,	,	PUNCT
admet-2214	549	7	t.	t.	PROPN
admet-2214	549	8	hekmatara	hekmatara	PROPN
admet-2214	549	9	,	,	PUNCT
admet-2214	549	10	s.	s.	PROPN
admet-2214	549	11	dreis	dreis	PROPN
admet-2214	549	12	,	,	PUNCT
admet-2214	549	13	t.	t.	PROPN
admet-2214	549	14	vogel	vogel	PROPN
admet-2214	549	15	,	,	PUNCT
admet-2214	549	16	s.	s.	PROPN
admet-2214	549	17	gelperina	gelperina	PROPN
admet-2214	549	18	,	,	PUNCT
admet-2214	549	19	k.	k.	PROPN
admet-2214	549	20	langer	langer	PROPN
admet-2214	549	21	.	.	PUNCT
admet-2214	550	1	covalent	covalent	ADJ
admet-2214	550	2	attachment	attachment	NOUN
admet-2214	550	3	of	of	ADP
admet-2214	550	4	apolipoprotein	apolipoprotein	ADJ
admet-2214	550	5	a	a	PRON
admet-2214	550	6	-	-	PUNCT
admet-2214	550	7	i	i	PRON
admet-2214	550	8	and	and	CCONJ
admet-2214	550	9	apolipoprotein	apolipoprotein	ADJ
admet-2214	550	10	b-100	b-100	ADP
admet-2214	550	11	to	to	ADP
admet-2214	550	12	albumin	albumin	ADJ
admet-2214	550	13	nanoparticles	nanoparticle	NOUN
admet-2214	550	14	enables	enable	VERB
admet-2214	550	15	drug	drug	NOUN
admet-2214	550	16	transport	transport	NOUN
admet-2214	550	17	into	into	ADP
admet-2214	550	18	the	the	DET
admet-2214	550	19	brain	brain	NOUN
admet-2214	550	20	.	.	PUNCT
admet-2214	551	1	journal	journal	PROPN
admet-2214	551	2	of	of	ADP
admet-2214	551	3	controlled	control	VERB
admet-2214	551	4	release	release	NOUN
admet-2214	551	5	118	118	NUM
admet-2214	551	6	(	(	PUNCT
admet-2214	551	7	2007	2007	NUM
admet-2214	551	8	)	)	PUNCT
admet-2214	551	9	54	54	NUM
admet-2214	551	10	-	-	SYM
admet-2214	551	11	58	58	NUM
admet-2214	551	12	.	.	PUNCT
admet-2214	552	1	https://doi.org/10.1016/j.jconrel.2006.12.012	https://doi.org/10.1016/j.jconrel.2006.12.012	NOUN
admet-2214	552	2	[	[	X
admet-2214	552	3	39	39	NUM
admet-2214	552	4	]	]	PUNCT
admet-2214	552	5	m.	m.	NOUN
admet-2214	552	6	kulkarni	kulkarni	PROPN
admet-2214	552	7	,	,	PUNCT
admet-2214	552	8	k.	k.	PROPN
admet-2214	552	9	patel	patel	PROPN
admet-2214	552	10	,	,	PUNCT
admet-2214	552	11	a.	a.	PROPN
admet-2214	552	12	patel	patel	PROPN
admet-2214	552	13	,	,	PUNCT
admet-2214	552	14	s.	s.	PROPN
admet-2214	552	15	patel	patel	PROPN
admet-2214	552	16	,	,	PUNCT
admet-2214	552	17	j.	j.	PROPN
admet-2214	552	18	desai	desai	PROPN
admet-2214	552	19	,	,	PUNCT
admet-2214	552	20	m.	m.	NOUN
admet-2214	552	21	patel	patel	PROPN
admet-2214	552	22	,	,	PUNCT
admet-2214	552	23	u.	u.	PROPN
admet-2214	552	24	shah	shah	PROPN
admet-2214	552	25	,	,	PUNCT
admet-2214	552	26	a.	a.	NOUN
admet-2214	552	27	patel	patel	PROPN
admet-2214	552	28	,	,	PUNCT
admet-2214	552	29	n.	n.	PROPN
admet-2214	552	30	solanki	solanki	PROPN
admet-2214	552	31	.	.	PUNCT
admet-2214	553	1	nanomaterials	nanomaterial	NOUN
admet-2214	553	2	as	as	ADP
admet-2214	553	3	drug	drug	NOUN
admet-2214	553	4	delivery	delivery	NOUN
admet-2214	553	5	agents	agent	NOUN
admet-2214	553	6	for	for	ADP
admet-2214	553	7	overcoming	overcome	VERB
admet-2214	553	8	the	the	DET
admet-2214	553	9	blood	blood	NOUN
admet-2214	553	10	-	-	PUNCT
admet-2214	553	11	brain	brain	NOUN
admet-2214	553	12	barrier	barrier	NOUN
admet-2214	553	13	:	:	PUNCT
admet-2214	553	14	a	a	DET
admet-2214	553	15	comprehensive	comprehensive	ADJ
admet-2214	553	16	review	review	NOUN
admet-2214	553	17	.	.	PUNCT
admet-2214	554	1	admet	admet	PROPN
admet-2214	554	2	and	and	CCONJ
admet-2214	554	3	dmpk	dmpk	PROPN
admet-2214	554	4	12	12	NUM
admet-2214	554	5	(	(	PUNCT
admet-2214	554	6	2024	2024	NUM
admet-2214	554	7	)	)	PUNCT
admet-2214	554	8	63	63	NUM
admet-2214	554	9	-	-	SYM
admet-2214	554	10	105	105	NUM
admet-2214	554	11	.	.	PUNCT
admet-2214	555	1	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2214	556	1	[	[	X
admet-2214	556	2	40	40	NUM
admet-2214	556	3	]	]	PUNCT
admet-2214	556	4	m.	m.	PROPN
admet-2214	556	5	shilo	shilo	PROPN
admet-2214	556	6	,	,	PUNCT
admet-2214	556	7	m.	m.	PROPN
admet-2214	556	8	motiei	motiei	PROPN
admet-2214	556	9	,	,	PUNCT
admet-2214	556	10	p.	p.	PROPN
admet-2214	556	11	hana	hana	PROPN
admet-2214	556	12	,	,	PUNCT
admet-2214	556	13	r.	r.	PROPN
admet-2214	556	14	popovtzer	popovtzer	PROPN
admet-2214	556	15	.	.	PUNCT
admet-2214	557	1	transport	transport	NOUN
admet-2214	557	2	of	of	ADP
admet-2214	557	3	nanoparticles	nanoparticle	NOUN
admet-2214	557	4	through	through	ADP
admet-2214	557	5	the	the	DET
admet-2214	557	6	blood	blood	NOUN
admet-2214	557	7	-	-	PUNCT
admet-2214	557	8	brain	brain	NOUN
admet-2214	557	9	barrier	barrier	NOUN
admet-2214	557	10	for	for	ADP
admet-2214	557	11	imaging	imaging	NOUN
admet-2214	557	12	and	and	CCONJ
admet-2214	557	13	therapeutic	therapeutic	ADJ
admet-2214	557	14	applications	application	NOUN
admet-2214	557	15	.	.	PUNCT
admet-2214	558	1	nanoscale	nanoscale	NOUN
admet-2214	558	2	6	6	NUM
admet-2214	558	3	(	(	PUNCT
admet-2214	558	4	2014	2014	NUM
admet-2214	558	5	)	)	PUNCT
admet-2214	558	6	2146	2146	NUM
admet-2214	558	7	-	-	SYM
admet-2214	558	8	2152	2152	NUM
admet-2214	558	9	.	.	PUNCT
admet-2214	559	1	https://doi.org/10.1039/c3nr04878k	https://doi.org/10.1039/c3nr04878k	PROPN
admet-2214	560	1	[	[	X
admet-2214	560	2	41	41	NUM
admet-2214	560	3	]	]	PUNCT
admet-2214	560	4	s.	s.	PROPN
admet-2214	560	5	guerrero	guerrero	PROPN
admet-2214	560	6	,	,	PUNCT
admet-2214	560	7	e.	e.	PROPN
admet-2214	560	8	araya	araya	PROPN
admet-2214	560	9	,	,	PUNCT
admet-2214	560	10	j.l	j.l	PROPN
admet-2214	560	11	.	.	PROPN
admet-2214	560	12	fiedler	fiedler	PROPN
admet-2214	560	13	,	,	PUNCT
admet-2214	560	14	j.i	j.i	PROPN
admet-2214	560	15	.	.	PROPN
admet-2214	560	16	arias	arias	PROPN
admet-2214	560	17	,	,	PUNCT
admet-2214	560	18	c.	c.	NOUN
admet-2214	560	19	adura	adura	NOUN
admet-2214	560	20	,	,	PUNCT
admet-2214	560	21	f.	f.	PROPN
admet-2214	560	22	albericio	albericio	PROPN
admet-2214	560	23	,	,	PUNCT
admet-2214	560	24	e.	e.	PROPN
admet-2214	560	25	giralt	giralt	PROPN
admet-2214	560	26	,	,	PUNCT
admet-2214	560	27	j.l	j.l	PROPN
admet-2214	560	28	.	.	PROPN
admet-2214	560	29	arias	arias	PROPN
admet-2214	560	30	,	,	PUNCT
admet-2214	560	31	m.s	m.s	PROPN
admet-2214	560	32	.	.	PROPN
admet-2214	560	33	fernndez	fernndez	PROPN
admet-2214	560	34	,	,	PUNCT
admet-2214	560	35	m.j	m.j	PROPN
admet-2214	560	36	.	.	PROPN
admet-2214	560	37	kogan	kogan	PROPN
admet-2214	560	38	.	.	PUNCT
admet-2214	561	1	improving	improve	VERB
admet-2214	561	2	the	the	DET
admet-2214	561	3	brain	brain	NOUN
admet-2214	561	4	delivery	delivery	NOUN
admet-2214	561	5	of	of	ADP
admet-2214	561	6	gold	gold	NOUN
admet-2214	561	7	nanoparticles	nanoparticle	NOUN
admet-2214	561	8	by	by	ADP
admet-2214	561	9	conjugation	conjugation	NOUN
admet-2214	561	10	with	with	ADP
admet-2214	561	11	an	an	DET
admet-2214	561	12	amphipathic	amphipathic	ADJ
admet-2214	561	13	peptide	peptide	NOUN
admet-2214	561	14	.	.	PUNCT
admet-2214	562	1	nanomedicine	nanomedicine	NOUN
admet-2214	562	2	5	5	NUM
admet-2214	562	3	(	(	PUNCT
admet-2214	562	4	2010	2010	NUM
admet-2214	562	5	)	)	PUNCT
admet-2214	562	6	897	897	NUM
admet-2214	562	7	-	-	SYM
admet-2214	562	8	913	913	NUM
admet-2214	562	9	.	.	PUNCT
admet-2214	563	1	https://doi.org/10.2217/nnm.10.74	https://doi.org/10.2217/nnm.10.74	PROPN
admet-2214	564	1	[	[	X
admet-2214	564	2	42	42	NUM
admet-2214	564	3	]	]	X
admet-2214	564	4	r.m	r.m	PROPN
admet-2214	564	5	.	.	PROPN
admet-2214	564	6	hochstrasser	hochstrasser	PROPN
admet-2214	564	7	.	.	PUNCT
admet-2214	565	1	two	two	NUM
admet-2214	565	2	-	-	PUNCT
admet-2214	565	3	dimensional	dimensional	ADJ
admet-2214	565	4	spectroscopy	spectroscopy	NOUN
admet-2214	565	5	at	at	ADP
admet-2214	565	6	infrared	infrared	ADJ
admet-2214	565	7	and	and	CCONJ
admet-2214	565	8	optical	optical	ADJ
admet-2214	565	9	frequencies	frequency	NOUN
admet-2214	565	10	.	.	PUNCT
admet-2214	566	1	proceedings	proceeding	NOUN
admet-2214	566	2	of	of	ADP
admet-2214	566	3	the	the	DET
admet-2214	566	4	national	national	PROPN
admet-2214	566	5	academy	academy	PROPN
admet-2214	566	6	of	of	ADP
admet-2214	566	7	sciences	sciences	PROPN
admet-2214	566	8	of	of	ADP
admet-2214	566	9	the	the	DET
admet-2214	566	10	united	united	PROPN
admet-2214	566	11	states	states	PROPN
admet-2214	566	12	of	of	ADP
admet-2214	566	13	america	america	PROPN
admet-2214	566	14	104	104	NUM
admet-2214	566	15	(	(	PUNCT
admet-2214	566	16	2007	2007	NUM
admet-2214	566	17	)	)	PUNCT
admet-2214	566	18	14190	14190	NUM
admet-2214	566	19	-	-	PUNCT
admet-2214	566	20	14196	14196	NUM
admet-2214	566	21	.	.	PUNCT
admet-2214	567	1	https://doi.org/10.1073/pnas.0704079104	https://doi.org/10.1073/pnas.0704079104	X
admet-2214	568	1	[	[	X
admet-2214	568	2	43	43	NUM
admet-2214	568	3	]	]	PUNCT
admet-2214	568	4	m.	m.	NOUN
admet-2214	568	5	biondi	biondi	PROPN
admet-2214	568	6	,	,	PUNCT
admet-2214	568	7	p.	p.	NOUN
admet-2214	568	8	d’alessandro	d’alessandro	PROPN
admet-2214	568	9	.	.	PUNCT
admet-2214	569	1	genus	genus	NOUN
admet-2214	569	2	-	-	PUNCT
admet-2214	569	3	group	group	NOUN
admet-2214	569	4	names	name	NOUN
admet-2214	569	5	of	of	ADP
admet-2214	569	6	afrotropical	afrotropical	ADJ
admet-2214	569	7	flea	flea	NOUN
admet-2214	569	8	beetles	beetle	NOUN
admet-2214	569	9	(	(	PUNCT
admet-2214	569	10	coleoptera	coleoptera	NOUN
admet-2214	569	11	:	:	PUNCT
admet-2214	569	12	chrysomelidae	chrysomelidae	NOUN
admet-2214	569	13	:	:	PUNCT
admet-2214	569	14	alticinae	alticinae	NOUN
admet-2214	569	15	):	):	PUNCT
admet-2214	569	16	annotated	annotate	VERB
admet-2214	569	17	catalogue	catalogue	NOUN
admet-2214	569	18	and	and	CCONJ
admet-2214	569	19	biogeographical	biogeographical	ADJ
admet-2214	569	20	notes	note	NOUN
admet-2214	569	21	.	.	PUNCT
admet-2214	570	1	european	european	ADJ
admet-2214	570	2	journal	journal	PROPN
admet-2214	570	3	of	of	ADP
admet-2214	570	4	entomology	entomology	NOUN
admet-2214	570	5	107	107	NUM
admet-2214	570	6	(	(	PUNCT
admet-2214	570	7	2010	2010	NUM
admet-2214	570	8	)	)	PUNCT
admet-2214	570	9	401	401	NUM
admet-2214	570	10	-	-	SYM
admet-2214	570	11	424	424	NUM
admet-2214	570	12	.	.	PUNCT
admet-2214	571	1	https://doi.org/10.14411/eje.2010.049	https://doi.org/10.14411/eje.2010.049	PRON
admet-2214	571	2	[	[	X
admet-2214	571	3	44	44	NUM
admet-2214	571	4	]	]	X
admet-2214	571	5	c.h.j	c.h.j	PROPN
admet-2214	571	6	.	.	PUNCT
admet-2214	571	7	choi	choi	PROPN
admet-2214	571	8	,	,	PUNCT
admet-2214	571	9	c.a	c.a	PROPN
admet-2214	571	10	.	.	PROPN
admet-2214	571	11	alabi	alabi	PROPN
admet-2214	571	12	,	,	PUNCT
admet-2214	571	13	p.	p.	PROPN
admet-2214	571	14	webster	webster	PROPN
admet-2214	571	15	,	,	PUNCT
admet-2214	571	16	m.e	m.e	PROPN
admet-2214	571	17	.	.	PROPN
admet-2214	571	18	davis	davis	PROPN
admet-2214	571	19	.	.	PUNCT
admet-2214	572	1	mechanism	mechanism	NOUN
admet-2214	572	2	of	of	ADP
admet-2214	572	3	active	active	ADJ
admet-2214	572	4	targeting	targeting	NOUN
admet-2214	572	5	in	in	ADP
admet-2214	572	6	solid	solid	ADJ
admet-2214	572	7	tumors	tumor	NOUN
admet-2214	572	8	with	with	ADP
admet-2214	572	9	transferrin	transferrin	NOUN
admet-2214	572	10	-	-	PUNCT
admet-2214	572	11	containing	contain	VERB
admet-2214	572	12	gold	gold	NOUN
admet-2214	572	13	nanoparticles	nanoparticle	NOUN
admet-2214	572	14	.	.	PUNCT
admet-2214	573	1	proceedings	proceeding	NOUN
admet-2214	573	2	of	of	ADP
admet-2214	573	3	the	the	DET
admet-2214	573	4	national	national	PROPN
admet-2214	573	5	academy	academy	PROPN
admet-2214	573	6	of	of	ADP
admet-2214	573	7	sciences	sciences	PROPN
admet-2214	573	8	of	of	ADP
admet-2214	573	9	the	the	DET
admet-2214	573	10	united	united	PROPN
admet-2214	573	11	states	states	PROPN
admet-2214	573	12	of	of	ADP
admet-2214	573	13	america	america	PROPN
admet-2214	573	14	107	107	NUM
admet-2214	573	15	(	(	PUNCT
admet-2214	573	16	2010	2010	NUM
admet-2214	573	17	)	)	PUNCT
admet-2214	573	18	1235	1235	NUM
admet-2214	573	19	-	-	SYM
admet-2214	573	20	1240	1240	NUM
admet-2214	573	21	.	.	PUNCT
admet-2214	573	22	https://doi.org/10.1073/pnas.0914140107	https://doi.org/10.1073/pnas.0914140107	NOUN
admet-2214	574	1	[	[	X
admet-2214	574	2	45	45	NUM
admet-2214	574	3	]	]	X
admet-2214	574	4	f.j	f.j	PROPN
admet-2214	574	5	.	.	PROPN
admet-2214	574	6	martinez	martinez	PROPN
admet-2214	574	7	-	-	PUNCT
admet-2214	574	8	veracoechea	veracoechea	PROPN
admet-2214	574	9	,	,	PUNCT
admet-2214	574	10	d.	d.	PROPN
admet-2214	574	11	frenkel	frenkel	PROPN
admet-2214	574	12	.	.	PUNCT
admet-2214	575	1	designing	design	VERB
admet-2214	575	2	super	super	ADJ
admet-2214	575	3	selectivity	selectivity	NOUN
admet-2214	575	4	in	in	ADP
admet-2214	575	5	multivalent	multivalent	NOUN
admet-2214	575	6	nanoparticle	nanoparticle	NOUN
admet-2214	575	7	binding	bind	VERB
admet-2214	575	8	.	.	PUNCT
admet-2214	576	1	proceedings	proceeding	NOUN
admet-2214	576	2	of	of	ADP
admet-2214	576	3	the	the	DET
admet-2214	576	4	national	national	PROPN
admet-2214	576	5	academy	academy	PROPN
admet-2214	576	6	of	of	ADP
admet-2214	576	7	sciences	sciences	PROPN
admet-2214	576	8	of	of	ADP
admet-2214	576	9	the	the	DET
admet-2214	576	10	united	united	PROPN
admet-2214	576	11	states	states	PROPN
admet-2214	576	12	of	of	ADP
admet-2214	576	13	america	america	PROPN
admet-2214	576	14	108	108	NUM
admet-2214	576	15	(	(	PUNCT
admet-2214	576	16	2011	2011	NUM
admet-2214	576	17	)	)	PUNCT
admet-2214	576	18	10963	10963	NUM
admet-2214	576	19	-	-	SYM
admet-2214	576	20	10968	10968	NUM
admet-2214	576	21	.	.	PUNCT
admet-2214	577	1	https://doi.org/10.1073/pnas.1105351108	https://doi.org/10.1073/pnas.1105351108	X
admet-2214	578	1	[	[	X
admet-2214	578	2	46	46	NUM
admet-2214	578	3	]	]	X
admet-2214	578	4	e.a	e.a	PROPN
admet-2214	578	5	.	.	PROPN
admet-2214	578	6	nance	nance	PROPN
admet-2214	578	7	,	,	PUNCT
admet-2214	578	8	g.f	g.f	PROPN
admet-2214	578	9	.	.	PROPN
admet-2214	578	10	woodworth	woodworth	PROPN
admet-2214	578	11	,	,	PUNCT
admet-2214	578	12	k.a	k.a	PROPN
admet-2214	578	13	.	.	PROPN
admet-2214	578	14	sailor	sailor	PROPN
admet-2214	578	15	,	,	PUNCT
admet-2214	578	16	t.y	t.y	PROPN
admet-2214	578	17	.	.	PUNCT
admet-2214	578	18	shih	shih	PROPN
admet-2214	578	19	,	,	PUNCT
admet-2214	578	20	q.	q.	PROPN
admet-2214	578	21	xu	xu	PROPN
admet-2214	578	22	,	,	PUNCT
admet-2214	578	23	g.	g.	PROPN
admet-2214	578	24	swaminathan	swaminathan	PROPN
admet-2214	578	25	,	,	PUNCT
admet-2214	578	26	d.	d.	PROPN
admet-2214	578	27	xiang	xiang	PROPN
admet-2214	578	28	,	,	PUNCT
admet-2214	578	29	c.	c.	PROPN
admet-2214	578	30	eberhart	eberhart	PROPN
admet-2214	578	31	,	,	PUNCT
admet-2214	578	32	j.	j.	PROPN
admet-2214	578	33	hanes	hanes	PROPN
admet-2214	578	34	.	.	PUNCT
admet-2214	579	1	a	a	DET
admet-2214	579	2	dense	dense	ADJ
admet-2214	579	3	poly(ethylene	poly(ethylene	ADJ
admet-2214	579	4	glycol	glycol	NOUN
admet-2214	579	5	)	)	PUNCT
admet-2214	579	6	coating	coating	NOUN
admet-2214	579	7	improves	improve	VERB
admet-2214	579	8	penetration	penetration	NOUN
admet-2214	579	9	of	of	ADP
admet-2214	579	10	large	large	ADJ
admet-2214	579	11	polymeric	polymeric	ADJ
admet-2214	579	12	nanoparticles	nanoparticle	NOUN
admet-2214	579	13	within	within	ADP
admet-2214	579	14	brain	brain	NOUN
admet-2214	579	15	tissue	tissue	NOUN
admet-2214	579	16	.	.	PUNCT
admet-2214	580	1	science	science	NOUN
admet-2214	580	2	translational	translational	ADJ
admet-2214	580	3	medicine	medicine	NOUN
admet-2214	580	4	4	4	NUM
admet-2214	580	5	(	(	PUNCT
admet-2214	580	6	2012	2012	NUM
admet-2214	580	7	)	)	PUNCT
admet-2214	580	8	149ra119	149ra119	NUM
admet-2214	580	9	https://doi.org/10.1126/scitranslmed.3003594	https://doi.org/10.1126/scitranslmed.3003594	X
admet-2214	580	10	https://doi.org/10.1016/j.jconrel.2016.05.044	https://doi.org/10.1016/j.jconrel.2016.05.044	PROPN
admet-2214	580	11	https://doi.org/10.1016/j.nano.2011.04.004	https://doi.org/10.1016/j.nano.2011.04.004	NUM
admet-2214	580	12	https://doi.org/10.3390/ijms15021812	https://doi.org/10.3390/ijms15021812	NOUN
admet-2214	580	13	https://doi.org/10.1016/j.colsurfb.2008.07.004	https://doi.org/10.1016/j.colsurfb.2008.07.004	PROPN
admet-2214	580	14	https://doi.org/10.1080/10611860400015936	https://doi.org/10.1080/10611860400015936	PROPN
admet-2214	580	15	https://doi.org/10.1021/nn200365a	https://doi.org/10.1021/nn200365a	PROPN
admet-2214	580	16	https://doi.org/10.1016/j.jconrel.2006.12.012	https://doi.org/10.1016/j.jconrel.2006.12.012	PROPN
admet-2214	580	17	https://doi.org/10.5599/admet.2043	https://doi.org/10.5599/admet.2043	NOUN
admet-2214	580	18	https://doi.org/10.1039/c3nr04878k	https://doi.org/10.1039/c3nr04878k	PROPN
admet-2214	580	19	https://doi.org/10.2217/nnm.10.74	https://doi.org/10.2217/nnm.10.74	VERB
admet-2214	580	20	https://doi.org/10.1073/pnas.0704079104	https://doi.org/10.1073/pnas.0704079104	PROPN
admet-2214	581	1	https://doi.org/10.14411/eje.2010.049	https://doi.org/10.14411/eje.2010.049	NOUN
admet-2214	581	2	https://doi.org/10.1073/pnas.0914140107	https://doi.org/10.1073/pnas.0914140107	NOUN
admet-2214	581	3	https://doi.org/10.1073/pnas.1105351108	https://doi.org/10.1073/pnas.1105351108	PROPN
admet-2214	581	4	https://doi.org/10.1126/scitranslmed.3003594	https://doi.org/10.1126/scitranslmed.3003594	X
admet-2214	581	5	admet	admet	PROPN
admet-2214	581	6	&	&	CCONJ
admet-2214	581	7	dmpk	dmpk	PROPN
admet-2214	581	8	12(3	12(3	PROPN
admet-2214	581	9	)	)	PUNCT
admet-2214	581	10	(	(	PUNCT
admet-2214	581	11	2024	2024	NUM
admet-2214	581	12	)	)	PUNCT
admet-2214	581	13	403	403	NUM
admet-2214	581	14	-	-	SYM
admet-2214	581	15	429	429	NUM
admet-2214	581	16	addressing	address	VERB
admet-2214	581	17	barriers	barrier	NOUN
admet-2214	581	18	in	in	ADP
admet-2214	581	19	diffuse	diffuse	ADJ
admet-2214	581	20	intrinsic	intrinsic	ADJ
admet-2214	581	21	pontine	pontine	ADJ
admet-2214	581	22	glioma	glioma	NOUN
admet-2214	581	23	doi	doi	NOUN
admet-2214	581	24	:	:	PUNCT
admet-2214	581	25	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	581	26	425	425	NUM
admet-2214	581	27	[	[	X
admet-2214	581	28	47	47	NUM
admet-2214	581	29	]	]	X
admet-2214	581	30	y.	y.	PROPN
admet-2214	581	31	zhang	zhang	PROPN
admet-2214	581	32	,	,	PUNCT
admet-2214	581	33	m.	m.	PROPN
admet-2214	581	34	li	li	PROPN
admet-2214	581	35	,	,	PUNCT
admet-2214	581	36	x.	x.	PROPN
admet-2214	581	37	gao	gao	PROPN
admet-2214	581	38	,	,	PUNCT
admet-2214	581	39	y.	y.	PROPN
admet-2214	581	40	chen	chen	PROPN
admet-2214	581	41	,	,	PUNCT
admet-2214	581	42	t.	t.	PROPN
admet-2214	581	43	liu	liu	PROPN
admet-2214	581	44	.	.	PUNCT
admet-2214	582	1	nanotechnology	nanotechnology	PROPN
admet-2214	582	2	in	in	ADP
admet-2214	582	3	cancer	cancer	NOUN
admet-2214	582	4	diagnosis	diagnosis	NOUN
admet-2214	582	5	:	:	PUNCT
admet-2214	582	6	progress	progress	NOUN
admet-2214	582	7	,	,	PUNCT
admet-2214	582	8	challenges	challenge	NOUN
admet-2214	582	9	and	and	CCONJ
admet-2214	582	10	opportunities	opportunity	NOUN
admet-2214	582	11	.	.	PUNCT
admet-2214	583	1	journal	journal	NOUN
admet-2214	583	2	of	of	ADP
admet-2214	583	3	hematology	hematology	NOUN
admet-2214	583	4	and	and	CCONJ
admet-2214	583	5	oncology	oncology	NOUN
admet-2214	583	6	12	12	NUM
admet-2214	583	7	(	(	PUNCT
admet-2214	583	8	2019	2019	NUM
admet-2214	583	9	)	)	PUNCT
admet-2214	583	10	137	137	NUM
admet-2214	583	11	.	.	PUNCT
admet-2214	584	1	https://doi.org/10.1186/s13045-019-0833-3	https://doi.org/10.1186/s13045-019-0833-3	NUM
admet-2214	585	1	[	[	X
admet-2214	585	2	48	48	NUM
admet-2214	585	3	]	]	PUNCT
admet-2214	585	4	w.	w.	PROPN
admet-2214	585	5	zhou	zhou	PROPN
admet-2214	585	6	,	,	PUNCT
admet-2214	585	7	x.	x.	PROPN
admet-2214	585	8	gao	gao	PROPN
admet-2214	585	9	,	,	PUNCT
admet-2214	585	10	d.	d.	PROPN
admet-2214	585	11	liu	liu	PROPN
admet-2214	585	12	,	,	PUNCT
admet-2214	585	13	x.	x.	PROPN
admet-2214	585	14	chen	chen	PROPN
admet-2214	585	15	.	.	PUNCT
admet-2214	586	1	gold	gold	ADJ
admet-2214	586	2	nanoparticles	nanoparticle	NOUN
admet-2214	586	3	for	for	ADP
admet-2214	586	4	in	in	ADP
admet-2214	586	5	vitro	vitro	X
admet-2214	586	6	diagnostics	diagnostic	NOUN
admet-2214	586	7	.	.	PUNCT
admet-2214	587	1	chemical	chemical	ADJ
admet-2214	587	2	reviews	review	NOUN
admet-2214	587	3	115	115	NUM
admet-2214	587	4	(	(	PUNCT
admet-2214	587	5	2015	2015	NUM
admet-2214	587	6	)	)	PUNCT
admet-2214	587	7	10575	10575	NUM
admet-2214	587	8	-	-	SYM
admet-2214	587	9	10636	10636	NUM
admet-2214	587	10	https://doi.org/10.1021/acs.chemrev.5b00100	https://doi.org/10.1021/acs.chemrev.5b00100	NOUN
admet-2214	588	1	[	[	X
admet-2214	588	2	49	49	NUM
admet-2214	588	3	]	]	PUNCT
admet-2214	588	4	s.	s.	PROPN
admet-2214	588	5	jia	jia	PROPN
admet-2214	588	6	,	,	PUNCT
admet-2214	588	7	r.	r.	PROPN
admet-2214	588	8	zhang	zhang	PROPN
admet-2214	588	9	,	,	PUNCT
admet-2214	588	10	z.	z.	PROPN
admet-2214	588	11	li	li	PROPN
admet-2214	588	12	,	,	PUNCT
admet-2214	588	13	j.	j.	PROPN
admet-2214	588	14	li	li	PROPN
admet-2214	588	15	.	.	PROPN
admet-2214	589	1	clinical	clinical	ADJ
admet-2214	589	2	and	and	CCONJ
admet-2214	589	3	biological	biological	ADJ
admet-2214	589	4	significance	significance	NOUN
admet-2214	589	5	of	of	ADP
admet-2214	589	6	circulating	circulate	VERB
admet-2214	589	7	tumor	tumor	NOUN
admet-2214	589	8	cells	cell	NOUN
admet-2214	589	9	,	,	PUNCT
admet-2214	589	10	circulating	circulate	VERB
admet-2214	589	11	tumor	tumor	NOUN
admet-2214	589	12	dna	dna	PROPN
admet-2214	589	13	,	,	PUNCT
admet-2214	589	14	and	and	CCONJ
admet-2214	589	15	exosomes	exosome	NOUN
admet-2214	589	16	as	as	ADP
admet-2214	589	17	biomarkers	biomarker	NOUN
admet-2214	589	18	in	in	ADP
admet-2214	589	19	colorectal	colorectal	ADJ
admet-2214	589	20	cancer	cancer	NOUN
admet-2214	589	21	.	.	PUNCT
admet-2214	590	1	oncotarget	oncotarget	NOUN
admet-2214	590	2	8	8	NUM
admet-2214	590	3	(	(	PUNCT
admet-2214	590	4	2017	2017	NUM
admet-2214	590	5	)	)	PUNCT
admet-2214	590	6	55632	55632	NUM
admet-2214	590	7	-	-	SYM
admet-2214	590	8	55645	55645	NUM
admet-2214	590	9	https://doi.org/10.18632/oncotarget.17184	https://doi.org/10.18632/oncotarget.17184	NOUN
admet-2214	591	1	[	[	X
admet-2214	591	2	50	50	NUM
admet-2214	591	3	]	]	PUNCT
admet-2214	591	4	s.	s.	PROPN
admet-2214	591	5	stamatovic	stamatovic	PROPN
admet-2214	591	6	,	,	PUNCT
admet-2214	591	7	r.	r.	PROPN
admet-2214	591	8	keep	keep	PROPN
admet-2214	591	9	,	,	PUNCT
admet-2214	591	10	a.	a.	NOUN
admet-2214	591	11	andjelkovic	andjelkovic	PROPN
admet-2214	591	12	.	.	PUNCT
admet-2214	592	1	brain	brain	NOUN
admet-2214	592	2	endothelial	endothelial	ADJ
admet-2214	592	3	cell	cell	NOUN
admet-2214	592	4	-	-	PUNCT
admet-2214	592	5	cell	cell	NOUN
admet-2214	592	6	junctions	junction	NOUN
admet-2214	592	7	:	:	PUNCT
admet-2214	592	8	how	how	SCONJ
admet-2214	592	9	to	to	ADP
admet-2214	592	10	&	&	CCONJ
admet-2214	592	11	#	#	SYM
admet-2214	592	12	x201c;open&#x201d	x201c;open&#x201d	NOUN
admet-2214	592	13	;	;	PUNCT
admet-2214	592	14	the	the	DET
admet-2214	592	15	blood	blood	NOUN
admet-2214	592	16	brain	brain	NOUN
admet-2214	592	17	barrier	barrier	NOUN
admet-2214	592	18	.	.	PUNCT
admet-2214	593	1	current	current	ADJ
admet-2214	593	2	neuropharmacology	neuropharmacology	NOUN
admet-2214	593	3	6	6	NUM
admet-2214	593	4	(	(	PUNCT
admet-2214	593	5	2008	2008	NUM
admet-2214	593	6	)	)	PUNCT
admet-2214	593	7	179	179	NUM
admet-2214	593	8	-	-	SYM
admet-2214	593	9	192	192	NUM
admet-2214	593	10	.	.	PUNCT
admet-2214	594	1	https://doi.org/10.2174/157015908785777210	https://doi.org/10.2174/157015908785777210	PRON
admet-2214	595	1	[	[	X
admet-2214	595	2	51	51	NUM
admet-2214	595	3	]	]	X
admet-2214	595	4	h.e	h.e	PROPN
admet-2214	595	5	.	.	PROPN
admet-2214	595	6	de	de	PROPN
admet-2214	595	7	vries	vries	PROPN
admet-2214	595	8	,	,	PUNCT
admet-2214	595	9	m.c.m	m.c.m	ADJ
admet-2214	595	10	.	.	PUNCT
admet-2214	595	11	blom	blom	NOUN
admet-2214	595	12	-	-	PUNCT
admet-2214	595	13	roosemalen	roosemalen	VERB
admet-2214	595	14	,	,	PUNCT
admet-2214	595	15	m.	m.	NOUN
admet-2214	595	16	van	van	PROPN
admet-2214	595	17	oosten	oosten	ADJ
admet-2214	595	18	,	,	PUNCT
admet-2214	595	19	a.g	a.g	PROPN
admet-2214	595	20	.	.	PROPN
admet-2214	595	21	de	de	PROPN
admet-2214	595	22	boer	boer	PROPN
admet-2214	595	23	,	,	PUNCT
admet-2214	595	24	t.j.c	t.j.c	PROPN
admet-2214	595	25	.	.	PUNCT
admet-2214	596	1	van	van	PROPN
admet-2214	596	2	berkel	berkel	PROPN
admet-2214	596	3	,	,	PUNCT
admet-2214	596	4	d.d	d.d	PROPN
admet-2214	596	5	.	.	PROPN
admet-2214	596	6	breimer	breimer	PROPN
admet-2214	596	7	,	,	PUNCT
admet-2214	596	8	j.	j.	PROPN
admet-2214	596	9	kuiper	kuiper	PROPN
admet-2214	596	10	.	.	PUNCT
admet-2214	597	1	the	the	DET
admet-2214	597	2	influence	influence	NOUN
admet-2214	597	3	of	of	ADP
admet-2214	597	4	cytokines	cytokine	NOUN
admet-2214	597	5	on	on	ADP
admet-2214	597	6	the	the	DET
admet-2214	597	7	integrity	integrity	NOUN
admet-2214	597	8	of	of	ADP
admet-2214	597	9	the	the	DET
admet-2214	597	10	blood	blood	NOUN
admet-2214	597	11	-	-	PUNCT
admet-2214	597	12	brain	brain	NOUN
admet-2214	597	13	barrier	barrier	NOUN
admet-2214	597	14	in	in	ADP
admet-2214	597	15	vitro	vitro	X
admet-2214	597	16	.	.	PUNCT
admet-2214	598	1	journal	journal	NOUN
admet-2214	598	2	of	of	ADP
admet-2214	598	3	neuroimmunology	neuroimmunology	NOUN
admet-2214	598	4	64	64	NUM
admet-2214	598	5	(	(	PUNCT
admet-2214	598	6	1996	1996	NUM
admet-2214	598	7	)	)	PUNCT
admet-2214	598	8	37	37	NUM
admet-2214	598	9	-	-	SYM
admet-2214	598	10	43	43	NUM
admet-2214	598	11	.	.	PUNCT
admet-2214	599	1	https://doi.org/10.1016/0165-5728(95)00148-4	https://doi.org/10.1016/0165-5728(95)00148-4	NOUN
admet-2214	599	2	[	[	X
admet-2214	599	3	52	52	NUM
admet-2214	599	4	]	]	SYM
admet-2214	599	5	a.r	a.r	PROPN
admet-2214	599	6	.	.	PROPN
admet-2214	599	7	khan	khan	PROPN
admet-2214	599	8	,	,	PUNCT
admet-2214	599	9	x.	x.	PROPN
admet-2214	599	10	yang	yang	PROPN
admet-2214	599	11	,	,	PUNCT
admet-2214	599	12	m.	m.	NOUN
admet-2214	599	13	fu	fu	PROPN
admet-2214	599	14	,	,	PUNCT
admet-2214	599	15	g.	g.	PROPN
admet-2214	599	16	zhai	zhai	PROPN
admet-2214	599	17	.	.	PUNCT
admet-2214	600	1	recent	recent	ADJ
admet-2214	600	2	progress	progress	NOUN
admet-2214	600	3	of	of	ADP
admet-2214	600	4	drug	drug	NOUN
admet-2214	600	5	nanoformulations	nanoformulation	NOUN
admet-2214	600	6	targeting	target	VERB
admet-2214	600	7	to	to	PART
admet-2214	600	8	brain	brain	NOUN
admet-2214	600	9	.	.	PUNCT
admet-2214	601	1	journal	journal	PROPN
admet-2214	601	2	of	of	ADP
admet-2214	601	3	controlled	control	VERB
admet-2214	601	4	release	release	NOUN
admet-2214	601	5	291	291	NUM
admet-2214	601	6	(	(	PUNCT
admet-2214	601	7	2018	2018	NUM
admet-2214	601	8	)	)	PUNCT
admet-2214	601	9	37	37	NUM
admet-2214	601	10	-	-	SYM
admet-2214	601	11	64	64	NUM
admet-2214	601	12	.	.	PUNCT
admet-2214	602	1	https://doi.org/10.1016/j.jconrel.2018.10.004	https://doi.org/10.1016/j.jconrel.2018.10.004	NOUN
admet-2214	602	2	[	[	X
admet-2214	602	3	53	53	NUM
admet-2214	602	4	]	]	X
admet-2214	602	5	a.r	a.r	PROPN
admet-2214	602	6	.	.	PROPN
admet-2214	602	7	khan	khan	PROPN
admet-2214	602	8	,	,	PUNCT
admet-2214	602	9	m.	m.	PROPN
admet-2214	602	10	liu	liu	PROPN
admet-2214	602	11	,	,	PUNCT
admet-2214	602	12	m.w	m.w	PROPN
admet-2214	602	13	.	.	PROPN
admet-2214	602	14	khan	khan	PROPN
admet-2214	602	15	,	,	PUNCT
admet-2214	602	16	g.	g.	PROPN
admet-2214	602	17	zhai	zhai	PROPN
admet-2214	602	18	.	.	PUNCT
admet-2214	603	1	progress	progress	NOUN
admet-2214	603	2	in	in	ADP
admet-2214	603	3	brain	brain	NOUN
admet-2214	603	4	targeting	target	VERB
admet-2214	603	5	drug	drug	NOUN
admet-2214	603	6	delivery	delivery	NOUN
admet-2214	603	7	system	system	NOUN
admet-2214	603	8	by	by	ADP
admet-2214	603	9	nasal	nasal	PROPN
admet-2214	603	10	route	route	PROPN
admet-2214	603	11	.	.	PUNCT
admet-2214	604	1	journal	journal	PROPN
admet-2214	604	2	of	of	ADP
admet-2214	604	3	controlled	control	VERB
admet-2214	604	4	release	release	NOUN
admet-2214	604	5	268	268	NUM
admet-2214	604	6	(	(	PUNCT
admet-2214	604	7	2017	2017	NUM
admet-2214	604	8	)	)	PUNCT
admet-2214	604	9	364	364	NUM
admet-2214	604	10	-	-	SYM
admet-2214	604	11	389	389	NUM
admet-2214	604	12	.	.	PUNCT
admet-2214	605	1	https://doi.org/10.1016/j.jconrel.2017.09.001	https://doi.org/10.1016/j.jconrel.2017.09.001	VERB
admet-2214	605	2	[	[	PUNCT
admet-2214	605	3	54	54	NUM
admet-2214	605	4	]	]	X
admet-2214	605	5	k.k	k.k	PROPN
admet-2214	605	6	.	.	PROPN
admet-2214	605	7	jain	jain	PROPN
admet-2214	605	8	.	.	PUNCT
admet-2214	606	1	nanobiotechnology	nanobiotechnology	NOUN
admet-2214	606	2	-	-	PUNCT
admet-2214	606	3	based	base	VERB
admet-2214	606	4	drug	drug	NOUN
admet-2214	606	5	delivery	delivery	NOUN
admet-2214	606	6	to	to	ADP
admet-2214	606	7	the	the	DET
admet-2214	606	8	central	central	ADJ
admet-2214	606	9	nervous	nervous	ADJ
admet-2214	606	10	system	system	NOUN
admet-2214	606	11	.	.	PUNCT
admet-2214	607	1	neurodegenerative	neurodegenerative	ADJ
admet-2214	607	2	diseases	disease	NOUN
admet-2214	607	3	4	4	NUM
admet-2214	607	4	(	(	PUNCT
admet-2214	607	5	2007	2007	NUM
admet-2214	607	6	)	)	PUNCT
admet-2214	607	7	287	287	NUM
admet-2214	607	8	-	-	SYM
admet-2214	607	9	291	291	NUM
admet-2214	607	10	.	.	PUNCT
admet-2214	608	1	https://doi.org/10.1159/000101884	https://doi.org/10.1159/000101884	PROPN
admet-2214	609	1	[	[	X
admet-2214	609	2	55	55	NUM
admet-2214	609	3	]	]	X
admet-2214	609	4	r.r	r.r	PROPN
admet-2214	609	5	.	.	PROPN
admet-2214	609	6	wakaskar	wakaskar	PROPN
admet-2214	609	7	.	.	PUNCT
admet-2214	610	1	promising	promising	ADJ
admet-2214	610	2	effects	effect	NOUN
admet-2214	610	3	of	of	ADP
admet-2214	610	4	nanomedicine	nanomedicine	NOUN
admet-2214	610	5	in	in	ADP
admet-2214	610	6	cancer	cancer	NOUN
admet-2214	610	7	drug	drug	NOUN
admet-2214	610	8	delivery	delivery	NOUN
admet-2214	610	9	.	.	PUNCT
admet-2214	611	1	journal	journal	NOUN
admet-2214	611	2	of	of	ADP
admet-2214	611	3	drug	drug	NOUN
admet-2214	611	4	targeting	target	VERB
admet-2214	611	5	26	26	NUM
admet-2214	611	6	(	(	PUNCT
admet-2214	611	7	2018	2018	NUM
admet-2214	611	8	)	)	PUNCT
admet-2214	611	9	319	319	NUM
admet-2214	611	10	-	-	SYM
admet-2214	611	11	324	324	NUM
admet-2214	611	12	.	.	PUNCT
admet-2214	612	1	https://doi.org/10.1080/1061186x.2017.1377207	https://doi.org/10.1080/1061186x.2017.1377207	NOUN
admet-2214	612	2	[	[	X
admet-2214	612	3	56	56	NUM
admet-2214	612	4	]	]	X
admet-2214	612	5	w.c	w.c	PROPN
admet-2214	612	6	.	.	PROPN
admet-2214	612	7	luo	luo	PROPN
admet-2214	612	8	,	,	PUNCT
admet-2214	612	9	x.	x.	PROPN
admet-2214	612	10	lu	lu	PROPN
admet-2214	612	11	.	.	PUNCT
admet-2214	613	1	solid	solid	ADJ
admet-2214	613	2	lipid	lipid	ADJ
admet-2214	613	3	nanoparticles	nanoparticle	NOUN
admet-2214	613	4	for	for	ADP
admet-2214	613	5	drug	drug	NOUN
admet-2214	613	6	delivery	delivery	NOUN
admet-2214	613	7	.	.	PUNCT
admet-2214	614	1	methods	method	NOUN
admet-2214	614	2	in	in	ADP
admet-2214	614	3	molecular	molecular	ADJ
admet-2214	614	4	biology	biology	NOUN
admet-2214	614	5	(	(	PUNCT
admet-2214	614	6	clifton	clifton	PROPN
admet-2214	614	7	,	,	PUNCT
admet-2214	614	8	n.j	n.j	PROPN
admet-2214	614	9	.	.	PROPN
admet-2214	614	10	)	)	PUNCT
admet-2214	614	11	2622	2622	NUM
admet-2214	614	12	(	(	PUNCT
admet-2214	614	13	2023	2023	NUM
admet-2214	614	14	)	)	PUNCT
admet-2214	614	15	139	139	NUM
admet-2214	614	16	-	-	SYM
admet-2214	614	17	146	146	NUM
admet-2214	614	18	.	.	PUNCT
admet-2214	614	19	https://doi.org/10.1007/978-1-0716-2954-3_12	https://doi.org/10.1007/978-1-0716-2954-3_12	PART
admet-2214	615	1	[	[	X
admet-2214	615	2	57	57	NUM
admet-2214	615	3	]	]	PUNCT
admet-2214	615	4	p.	p.	NOUN
admet-2214	615	5	yingchoncharoen	yingchoncharoen	PROPN
admet-2214	615	6	,	,	PUNCT
admet-2214	615	7	d.s	d.s	PROPN
admet-2214	615	8	.	.	PROPN
admet-2214	615	9	kalinowski	kalinowski	PROPN
admet-2214	615	10	,	,	PUNCT
admet-2214	615	11	d.r	d.r	PROPN
admet-2214	615	12	.	.	PROPN
admet-2214	615	13	richardson	richardson	PROPN
admet-2214	615	14	.	.	PUNCT
admet-2214	616	1	lipid	lipid	NOUN
admet-2214	616	2	-	-	PUNCT
admet-2214	616	3	based	base	VERB
admet-2214	616	4	drug	drug	NOUN
admet-2214	616	5	delivery	delivery	NOUN
admet-2214	616	6	systems	system	NOUN
admet-2214	616	7	in	in	ADP
admet-2214	616	8	cancer	cancer	NOUN
admet-2214	616	9	therapy	therapy	NOUN
admet-2214	616	10	:	:	PUNCT
admet-2214	616	11	what	what	PRON
admet-2214	616	12	is	be	AUX
admet-2214	616	13	available	available	ADJ
admet-2214	616	14	and	and	CCONJ
admet-2214	616	15	what	what	PRON
admet-2214	616	16	is	be	AUX
admet-2214	616	17	yet	yet	ADV
admet-2214	616	18	to	to	PART
admet-2214	616	19	come	come	VERB
admet-2214	616	20	.	.	PUNCT
admet-2214	617	1	pharmacological	pharmacological	ADJ
admet-2214	617	2	reviews	review	NOUN
admet-2214	617	3	68	68	NUM
admet-2214	617	4	(	(	PUNCT
admet-2214	617	5	2016	2016	NUM
admet-2214	617	6	)	)	PUNCT
admet-2214	617	7	701	701	NUM
admet-2214	617	8	-	-	SYM
admet-2214	617	9	787	787	NUM
admet-2214	617	10	.	.	PUNCT
admet-2214	618	1	https://doi.org/10.1124/pr.115.012070	https://doi.org/10.1124/pr.115.012070	NOUN
admet-2214	619	1	[	[	X
admet-2214	619	2	58	58	NUM
admet-2214	619	3	]	]	X
admet-2214	619	4	a.d	a.d	PROPN
admet-2214	619	5	.	.	PROPN
admet-2214	619	6	bangham	bangham	PROPN
admet-2214	619	7	,	,	PUNCT
admet-2214	619	8	m.m	m.m	PROPN
admet-2214	619	9	.	.	PROPN
admet-2214	619	10	standish	standish	PROPN
admet-2214	619	11	,	,	PUNCT
admet-2214	619	12	j.c	j.c	PROPN
admet-2214	619	13	.	.	PROPN
admet-2214	619	14	watkins	watkins	PROPN
admet-2214	619	15	.	.	PUNCT
admet-2214	620	1	diffusion	diffusion	NOUN
admet-2214	620	2	of	of	ADP
admet-2214	620	3	univalent	univalent	ADJ
admet-2214	620	4	ions	ion	NOUN
admet-2214	620	5	across	across	ADP
admet-2214	620	6	the	the	DET
admet-2214	620	7	lamellae	lamellae	NOUN
admet-2214	620	8	of	of	ADP
admet-2214	620	9	swollen	swollen	ADJ
admet-2214	620	10	phospholipids	phospholipid	NOUN
admet-2214	620	11	.	.	PUNCT
admet-2214	621	1	journal	journal	NOUN
admet-2214	621	2	of	of	ADP
admet-2214	621	3	molecular	molecular	ADJ
admet-2214	621	4	biology	biology	NOUN
admet-2214	621	5	13	13	NUM
admet-2214	621	6	(	(	PUNCT
admet-2214	621	7	1965	1965	NUM
admet-2214	621	8	)	)	PUNCT
admet-2214	621	9	238	238	NUM
admet-2214	621	10	-	-	SYM
admet-2214	621	11	252	252	NUM
admet-2214	621	12	.	.	PUNCT
admet-2214	622	1	https://doi.org/10.1016/s0022-2836(65)80093-6	https://doi.org/10.1016/s0022-2836(65)80093-6	PROPN
admet-2214	623	1	[	[	X
admet-2214	623	2	59	59	NUM
admet-2214	623	3	]	]	X
admet-2214	623	4	g.	g.	PROPN
admet-2214	623	5	yang	yang	PROPN
admet-2214	623	6	,	,	PUNCT
admet-2214	623	7	y.	y.	PROPN
admet-2214	623	8	liu	liu	PROPN
admet-2214	623	9	,	,	PUNCT
admet-2214	623	10	s.	s.	PROPN
admet-2214	623	11	jin	jin	PROPN
admet-2214	623	12	,	,	PUNCT
admet-2214	623	13	c.x	c.x	PROPN
admet-2214	623	14	.	.	PROPN
admet-2214	623	15	zhao	zhao	PROPN
admet-2214	623	16	.	.	PUNCT
admet-2214	624	1	development	development	NOUN
admet-2214	624	2	of	of	ADP
admet-2214	624	3	core	core	ADJ
admet-2214	624	4	-	-	PUNCT
admet-2214	624	5	shell	shell	NOUN
admet-2214	624	6	nanoparticle	nanoparticle	NOUN
admet-2214	624	7	drug	drug	NOUN
admet-2214	624	8	delivery	delivery	NOUN
admet-2214	624	9	systems	system	NOUN
admet-2214	624	10	based	base	VERB
admet-2214	624	11	on	on	ADP
admet-2214	624	12	biomimetic	biomimetic	ADJ
admet-2214	624	13	mineralization	mineralization	NOUN
admet-2214	624	14	.	.	PUNCT
admet-2214	625	1	chembiochem	chembiochem	PROPN
admet-2214	625	2	21	21	NUM
admet-2214	625	3	(	(	PUNCT
admet-2214	625	4	2020	2020	NUM
admet-2214	625	5	)	)	PUNCT
admet-2214	625	6	2871	2871	NUM
admet-2214	625	7	-	-	SYM
admet-2214	625	8	2879	2879	NUM
admet-2214	625	9	.	.	PUNCT
admet-2214	626	1	https://doi.org/10.1002/cbic.202000105	https://doi.org/10.1002/cbic.202000105	PROPN
admet-2214	627	1	[	[	X
admet-2214	627	2	60	60	NUM
admet-2214	627	3	]	]	X
admet-2214	627	4	c.	c.	NOUN
admet-2214	627	5	has	have	VERB
admet-2214	627	6	,	,	PUNCT
admet-2214	627	7	p.	p.	PROPN
admet-2214	627	8	sunthar	sunthar	PROPN
admet-2214	627	9	.	.	PUNCT
admet-2214	628	1	a	a	DET
admet-2214	628	2	comprehensive	comprehensive	ADJ
admet-2214	628	3	review	review	NOUN
admet-2214	628	4	on	on	ADP
admet-2214	628	5	recent	recent	ADJ
admet-2214	628	6	preparation	preparation	NOUN
admet-2214	628	7	techniques	technique	NOUN
admet-2214	628	8	of	of	ADP
admet-2214	628	9	liposomes	liposome	NOUN
admet-2214	628	10	.	.	PUNCT
admet-2214	629	1	journal	journal	NOUN
admet-2214	629	2	of	of	ADP
admet-2214	629	3	liposome	liposome	PROPN
admet-2214	629	4	research	research	NOUN
admet-2214	629	5	30	30	NUM
admet-2214	629	6	(	(	PUNCT
admet-2214	629	7	2020	2020	NUM
admet-2214	629	8	)	)	PUNCT
admet-2214	629	9	336	336	NUM
admet-2214	629	10	-	-	SYM
admet-2214	629	11	365	365	NUM
admet-2214	629	12	.	.	PUNCT
admet-2214	629	13	https://doi.org/10.1080/08982104.2019.1668010	https://doi.org/10.1080/08982104.2019.1668010	PROPN
admet-2214	630	1	[	[	X
admet-2214	630	2	61	61	NUM
admet-2214	630	3	]	]	PUNCT
admet-2214	630	4	l.	l.	PROPN
admet-2214	630	5	maja	maja	PROPN
admet-2214	630	6	,	,	PUNCT
admet-2214	630	7	k.	k.	PROPN
admet-2214	630	8	željko	željko	PROPN
admet-2214	630	9	,	,	PUNCT
admet-2214	630	10	p.	p.	PROPN
admet-2214	630	11	mateja	mateja	NOUN
admet-2214	630	12	.	.	PUNCT
admet-2214	631	1	sustainable	sustainable	ADJ
admet-2214	631	2	technologies	technology	NOUN
admet-2214	631	3	for	for	ADP
admet-2214	631	4	liposome	liposome	NOUN
admet-2214	631	5	preparation	preparation	NOUN
admet-2214	631	6	.	.	PUNCT
admet-2214	632	1	journal	journal	NOUN
admet-2214	632	2	of	of	ADP
admet-2214	632	3	supercritical	supercritical	ADJ
admet-2214	632	4	fluids	fluid	NOUN
admet-2214	632	5	165	165	NUM
admet-2214	632	6	(	(	PUNCT
admet-2214	632	7	2020	2020	NUM
admet-2214	632	8	)	)	PUNCT
admet-2214	632	9	104984	104984	NUM
admet-2214	632	10	.	.	PUNCT
admet-2214	633	1	https://doi.org/10.1016/j.supflu.2020.104984	https://doi.org/10.1016/j.supflu.2020.104984	PROPN
admet-2214	633	2	[	[	X
admet-2214	633	3	62	62	NUM
admet-2214	633	4	]	]	PUNCT
admet-2214	633	5	r.	r.	PROPN
admet-2214	633	6	ran	run	VERB
admet-2214	633	7	,	,	PUNCT
admet-2214	633	8	a.p.j	a.p.j	ADJ
admet-2214	633	9	.	.	PUNCT
admet-2214	634	1	middelberg	middelberg	PROPN
admet-2214	634	2	,	,	PUNCT
admet-2214	634	3	c.x	c.x	PROPN
admet-2214	634	4	.	.	PROPN
admet-2214	634	5	zhao	zhao	PROPN
admet-2214	634	6	.	.	PUNCT
admet-2214	635	1	microfluidic	microfluidic	ADJ
admet-2214	635	2	synthesis	synthesis	NOUN
admet-2214	635	3	of	of	ADP
admet-2214	635	4	multifunctional	multifunctional	ADJ
admet-2214	635	5	liposomes	liposome	NOUN
admet-2214	635	6	for	for	ADP
admet-2214	635	7	tumour	tumour	NOUN
admet-2214	635	8	targeting	targeting	NOUN
admet-2214	635	9	.	.	PUNCT
admet-2214	636	1	colloids	colloid	NOUN
admet-2214	636	2	and	and	CCONJ
admet-2214	636	3	surfaces	surface	NOUN
admet-2214	636	4	b	b	NUM
admet-2214	636	5	:	:	PUNCT
admet-2214	636	6	biointerfaces	biointerface	NOUN
admet-2214	636	7	148	148	NUM
admet-2214	636	8	(	(	PUNCT
admet-2214	636	9	2016	2016	NUM
admet-2214	636	10	)	)	PUNCT
admet-2214	636	11	402	402	NUM
admet-2214	636	12	-	-	SYM
admet-2214	636	13	410	410	NUM
admet-2214	636	14	.	.	PUNCT
admet-2214	637	1	https://doi.org/10.1016/j.colsurfb.2016.09.016	https://doi.org/10.1016/j.colsurfb.2016.09.016	PROPN
admet-2214	637	2	[	[	PUNCT
admet-2214	637	3	63	63	NUM
admet-2214	637	4	]	]	PUNCT
admet-2214	637	5	r.	r.	PROPN
admet-2214	637	6	ran	run	VERB
admet-2214	637	7	,	,	PUNCT
admet-2214	637	8	h.	h.	PROPN
admet-2214	637	9	wang	wang	PROPN
admet-2214	637	10	,	,	PUNCT
admet-2214	637	11	y.	y.	PROPN
admet-2214	637	12	liu	liu	PROPN
admet-2214	637	13	,	,	PUNCT
admet-2214	637	14	y.	y.	PROPN
admet-2214	637	15	hui	hui	PROPN
admet-2214	637	16	,	,	PUNCT
admet-2214	637	17	q.	q.	PROPN
admet-2214	637	18	sun	sun	PROPN
admet-2214	637	19	,	,	PUNCT
admet-2214	637	20	a.	a.	PROPN
admet-2214	637	21	seth	seth	PROPN
admet-2214	637	22	,	,	PUNCT
admet-2214	637	23	d.	d.	PROPN
admet-2214	637	24	wibowo	wibowo	PROPN
admet-2214	637	25	,	,	PUNCT
admet-2214	637	26	d.	d.	PROPN
admet-2214	637	27	chen	chen	PROPN
admet-2214	637	28	,	,	PUNCT
admet-2214	637	29	c.x	c.x	PROPN
admet-2214	637	30	.	.	PROPN
admet-2214	637	31	zhao	zhao	PROPN
admet-2214	637	32	.	.	PUNCT
admet-2214	638	1	microfluidic	microfluidic	ADJ
admet-2214	638	2	selfassembly	selfassembly	ADV
admet-2214	638	3	of	of	ADP
admet-2214	638	4	a	a	DET
admet-2214	638	5	combinatorial	combinatorial	ADJ
admet-2214	638	6	library	library	NOUN
admet-2214	638	7	of	of	ADP
admet-2214	638	8	singleand	singleand	NOUN
admet-2214	638	9	dual	dual	ADJ
admet-2214	638	10	-	-	PUNCT
admet-2214	638	11	ligand	ligand	NOUN
admet-2214	638	12	liposomes	liposome	NOUN
admet-2214	638	13	for	for	ADP
admet-2214	638	14	in	in	ADP
admet-2214	638	15	vitro	vitro	X
admet-2214	638	16	and	and	CCONJ
admet-2214	638	17	in	in	ADP
admet-2214	638	18	vivo	vivo	ADJ
admet-2214	638	19	tumor	tumor	NOUN
admet-2214	638	20	targeting	target	VERB
admet-2214	638	21	.	.	PUNCT
admet-2214	639	1	european	european	PROPN
admet-2214	639	2	journal	journal	PROPN
admet-2214	639	3	of	of	ADP
admet-2214	639	4	pharmaceutics	pharmaceutic	NOUN
admet-2214	639	5	and	and	CCONJ
admet-2214	639	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2214	639	7	130	130	NUM
admet-2214	639	8	(	(	PUNCT
admet-2214	639	9	2018	2018	NUM
admet-2214	639	10	)	)	PUNCT
admet-2214	639	11	1	1	NUM
admet-2214	639	12	-	-	SYM
admet-2214	639	13	10	10	NUM
admet-2214	639	14	.	.	PUNCT
admet-2214	640	1	https://doi.org/10.1016/j.ejpb.2018.06.017	https://doi.org/10.1016/j.ejpb.2018.06.017	NUM
admet-2214	640	2	[	[	SYM
admet-2214	640	3	64	64	NUM
admet-2214	640	4	]	]	PUNCT
admet-2214	640	5	r.	r.	PROPN
admet-2214	640	6	sonkar	sonkar	PROPN
admet-2214	640	7	,	,	PUNCT
admet-2214	640	8	sonali	sonali	PROPN
admet-2214	640	9	,	,	PUNCT
admet-2214	640	10	a.	a.	PROPN
admet-2214	640	11	jha	jha	PROPN
admet-2214	640	12	,	,	PUNCT
admet-2214	640	13	m.k	m.k	PROPN
admet-2214	640	14	.	.	PROPN
admet-2214	640	15	viswanadh	viswanadh	PROPN
admet-2214	640	16	,	,	PUNCT
admet-2214	640	17	a.s	a.s	PROPN
admet-2214	640	18	.	.	PROPN
admet-2214	640	19	burande	burande	PROPN
admet-2214	640	20	,	,	PUNCT
admet-2214	640	21	narendra	narendra	PROPN
admet-2214	640	22	,	,	PUNCT
admet-2214	640	23	d.m	d.m	PROPN
admet-2214	640	24	.	.	PROPN
admet-2214	640	25	pawde	pawde	PROPN
admet-2214	640	26	,	,	PUNCT
admet-2214	640	27	k.k	k.k	PROPN
admet-2214	640	28	.	.	PROPN
admet-2214	640	29	patel	patel	PROPN
admet-2214	640	30	,	,	PUNCT
admet-2214	640	31	m.	m.	PROPN
admet-2214	640	32	singh	singh	PROPN
admet-2214	640	33	,	,	PUNCT
admet-2214	640	34	b.	b.	PROPN
admet-2214	640	35	koch	koch	PROPN
admet-2214	640	36	,	,	PUNCT
admet-2214	640	37	m.s	m.s	PROPN
admet-2214	640	38	.	.	PROPN
admet-2214	640	39	muthu	muthu	PROPN
admet-2214	640	40	.	.	PUNCT
admet-2214	641	1	gold	gold	NOUN
admet-2214	641	2	liposomes	liposome	NOUN
admet-2214	641	3	for	for	ADP
admet-2214	641	4	brain	brain	NOUN
admet-2214	641	5	-	-	PUNCT
admet-2214	641	6	targeted	target	VERB
admet-2214	641	7	drug	drug	NOUN
admet-2214	641	8	delivery	delivery	NOUN
admet-2214	641	9	:	:	PUNCT
admet-2214	641	10	formulation	formulation	NOUN
admet-2214	641	11	and	and	CCONJ
admet-2214	641	12	brain	brain	NOUN
admet-2214	641	13	distribution	distribution	NOUN
admet-2214	641	14	kinetics	kinetic	NOUN
admet-2214	641	15	.	.	PUNCT
admet-2214	642	1	materials	material	NOUN
admet-2214	642	2	science	science	NOUN
admet-2214	642	3	and	and	CCONJ
admet-2214	642	4	engineering	engineering	NOUN
admet-2214	642	5	c	c	PROPN
admet-2214	642	6	120	120	NUM
admet-2214	642	7	(	(	PUNCT
admet-2214	642	8	2021	2021	NUM
admet-2214	642	9	)	)	PUNCT
admet-2214	642	10	111652	111652	NUM
admet-2214	642	11	.	.	PUNCT
admet-2214	643	1	https://doi.org/10.1016/j.msec.2020.111652	https://doi.org/10.1016/j.msec.2020.111652	PROPN
admet-2214	643	2	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	643	3	https://doi.org/10.1186/s13045-019-0833-3	https://doi.org/10.1186/s13045-019-0833-3	NUM
admet-2214	644	1	https://doi.org/10.1021/acs.chemrev.5b00100	https://doi.org/10.1021/acs.chemrev.5b00100	NOUN
admet-2214	644	2	https://doi.org/10.18632/oncotarget.17184	https://doi.org/10.18632/oncotarget.17184	VERB
admet-2214	644	3	https://doi.org/10.2174/157015908785777210	https://doi.org/10.2174/157015908785777210	ADP
admet-2214	644	4	https://doi.org/10.1016/0165-5728(95)00148-4	https://doi.org/10.1016/0165-5728(95)00148-4	NOUN
admet-2214	644	5	https://doi.org/10.1016/j.jconrel.2018.10.004	https://doi.org/10.1016/j.jconrel.2018.10.004	NOUN
admet-2214	644	6	https://doi.org/10.1016/j.jconrel.2017.09.001	https://doi.org/10.1016/j.jconrel.2017.09.001	VERB
admet-2214	644	7	https://doi.org/10.1159/000101884	https://doi.org/10.1159/000101884	PROPN
admet-2214	644	8	https://doi.org/10.1080/1061186x.2017.1377207	https://doi.org/10.1080/1061186x.2017.1377207	NOUN
admet-2214	644	9	https://doi.org/10.1007/978-1-0716-2954-3_12	https://doi.org/10.1007/978-1-0716-2954-3_12	ADJ
admet-2214	644	10	https://doi.org/10.1124/pr.115.012070	https://doi.org/10.1124/pr.115.012070	PROPN
admet-2214	644	11	https://doi.org/10.1016/s0022-2836(65)80093-6	https://doi.org/10.1016/s0022-2836(65)80093-6	PROPN
admet-2214	644	12	https://doi.org/10.1002/cbic.202000105	https://doi.org/10.1002/cbic.202000105	PROPN
admet-2214	644	13	https://doi.org/10.1080/08982104.2019.1668010	https://doi.org/10.1080/08982104.2019.1668010	PROPN
admet-2214	645	1	https://doi.org/10.1016/j.supflu.2020.104984	https://doi.org/10.1016/j.supflu.2020.104984	PROPN
admet-2214	645	2	https://doi.org/10.1016/j.colsurfb.2016.09.016	https://doi.org/10.1016/j.colsurfb.2016.09.016	VERB
admet-2214	645	3	https://doi.org/10.1016/j.ejpb.2018.06.017	https://doi.org/10.1016/j.ejpb.2018.06.017	NUM
admet-2214	645	4	https://doi.org/10.1016/j.msec.2020.111652	https://doi.org/10.1016/j.msec.2020.111652	PROPN
admet-2214	645	5	z.	z.	PROPN
admet-2214	645	6	presswala	presswala	PROPN
admet-2214	645	7	et	et	PROPN
admet-2214	645	8	al	al	PROPN
admet-2214	645	9	.	.	PROPN
admet-2214	645	10	admet	admet	PROPN
admet-2214	645	11	&	&	CCONJ
admet-2214	645	12	dmpk	dmpk	PROPN
admet-2214	645	13	12(3	12(3	PROPN
admet-2214	645	14	)	)	PUNCT
admet-2214	645	15	(	(	PUNCT
admet-2214	645	16	2024	2024	NUM
admet-2214	645	17	)	)	PUNCT
admet-2214	645	18	403	403	NUM
admet-2214	646	1	-	-	SYM
admet-2214	646	2	429	429	NUM
admet-2214	646	3	426	426	NUM
admet-2214	647	1	[	[	X
admet-2214	647	2	65	65	NUM
admet-2214	647	3	]	]	PUNCT
admet-2214	647	4	x.	x.	PROPN
admet-2214	647	5	wei	wei	PROPN
admet-2214	647	6	,	,	PUNCT
admet-2214	647	7	x.	x.	PROPN
admet-2214	647	8	chen	chen	PROPN
admet-2214	647	9	,	,	PUNCT
admet-2214	647	10	m.	m.	PROPN
admet-2214	647	11	ying	ying	PROPN
admet-2214	647	12	,	,	PUNCT
admet-2214	647	13	w.	w.	PROPN
admet-2214	647	14	lu	lu	PROPN
admet-2214	647	15	.	.	PUNCT
admet-2214	648	1	brain	brain	PROPN
admet-2214	648	2	tumor	tumor	NOUN
admet-2214	648	3	-	-	PUNCT
admet-2214	648	4	targeted	target	VERB
admet-2214	648	5	drug	drug	NOUN
admet-2214	648	6	delivery	delivery	NOUN
admet-2214	648	7	strategies	strategy	NOUN
admet-2214	648	8	.	.	PUNCT
admet-2214	649	1	acta	acta	PROPN
admet-2214	649	2	pharmaceutica	pharmaceutica	PROPN
admet-2214	649	3	sinica	sinica	PROPN
admet-2214	649	4	b	b	PROPN
admet-2214	649	5	4	4	NUM
admet-2214	649	6	(	(	PUNCT
admet-2214	649	7	2014	2014	NUM
admet-2214	649	8	)	)	PUNCT
admet-2214	649	9	193	193	NUM
admet-2214	649	10	-	-	SYM
admet-2214	649	11	201	201	NUM
admet-2214	649	12	.	.	PUNCT
admet-2214	650	1	https://doi.org/10.1016/j.apsb.2014.03.001	https://doi.org/10.1016/j.apsb.2014.03.001	PRON
admet-2214	650	2	[	[	X
admet-2214	650	3	66	66	NUM
admet-2214	650	4	]	]	PUNCT
admet-2214	650	5	sonali	sonali	PROPN
admet-2214	650	6	,	,	PUNCT
admet-2214	650	7	r.p	r.p	PROPN
admet-2214	650	8	.	.	PROPN
admet-2214	650	9	singh	singh	PROPN
admet-2214	650	10	,	,	PUNCT
admet-2214	650	11	n.	n.	PROPN
admet-2214	650	12	singh	singh	PROPN
admet-2214	650	13	,	,	PUNCT
admet-2214	650	14	g.	g.	PROPN
admet-2214	650	15	sharma	sharma	PROPN
admet-2214	650	16	,	,	PUNCT
admet-2214	650	17	m.r	m.r	PROPN
admet-2214	650	18	.	.	PROPN
admet-2214	650	19	vijayakumar	vijayakumar	PROPN
admet-2214	650	20	,	,	PUNCT
admet-2214	650	21	b.	b.	PROPN
admet-2214	650	22	koch	koch	PROPN
admet-2214	650	23	,	,	PUNCT
admet-2214	650	24	s.	s.	PROPN
admet-2214	650	25	singh	singh	PROPN
admet-2214	650	26	,	,	PUNCT
admet-2214	650	27	u.	u.	PROPN
admet-2214	650	28	singh	singh	PROPN
admet-2214	650	29	,	,	PUNCT
admet-2214	650	30	d.	d.	NOUN
admet-2214	650	31	dash	dash	NOUN
admet-2214	650	32	,	,	PUNCT
admet-2214	650	33	b.l	b.l	PROPN
admet-2214	650	34	.	.	PROPN
admet-2214	650	35	pandey	pandey	PROPN
admet-2214	650	36	,	,	PUNCT
admet-2214	650	37	m.s	m.s	PROPN
admet-2214	650	38	.	.	PROPN
admet-2214	650	39	muthu	muthu	PROPN
admet-2214	650	40	.	.	PUNCT
admet-2214	651	1	transferrin	transferrin	PROPN
admet-2214	651	2	liposomes	liposome	NOUN
admet-2214	651	3	of	of	ADP
admet-2214	651	4	docetaxel	docetaxel	PROPN
admet-2214	651	5	for	for	ADP
admet-2214	651	6	brain	brain	NOUN
admet-2214	651	7	-	-	PUNCT
admet-2214	651	8	targeted	target	VERB
admet-2214	651	9	cancer	cancer	NOUN
admet-2214	651	10	applications	application	NOUN
admet-2214	651	11	:	:	PUNCT
admet-2214	651	12	formulation	formulation	NOUN
admet-2214	651	13	and	and	CCONJ
admet-2214	651	14	brain	brain	NOUN
admet-2214	651	15	theranostics	theranostic	NOUN
admet-2214	651	16	.	.	PUNCT
admet-2214	652	1	drug	drug	NOUN
admet-2214	652	2	delivery	delivery	NOUN
admet-2214	652	3	23	23	NUM
admet-2214	652	4	(	(	PUNCT
admet-2214	652	5	2016	2016	NUM
admet-2214	652	6	)	)	PUNCT
admet-2214	652	7	1261	1261	NUM
admet-2214	652	8	-	-	SYM
admet-2214	652	9	1271	1271	NUM
admet-2214	652	10	.	.	PUNCT
admet-2214	653	1	https://doi.org/10.3109/10717544.2016.1162878	https://doi.org/10.3109/10717544.2016.1162878	PROPN
admet-2214	654	1	[	[	X
admet-2214	654	2	67	67	NUM
admet-2214	654	3	]	]	X
admet-2214	654	4	y.	y.	PROPN
admet-2214	654	5	hu	hu	PROPN
admet-2214	654	6	,	,	PUNCT
admet-2214	654	7	j.	j.	PROPN
admet-2214	654	8	rip	rip	PROPN
admet-2214	654	9	,	,	PUNCT
admet-2214	654	10	p.j	p.j	PROPN
admet-2214	654	11	.	.	PROPN
admet-2214	654	12	gaillard	gaillard	PROPN
admet-2214	654	13	,	,	PUNCT
admet-2214	654	14	e.c.m	e.c.m	ADJ
admet-2214	654	15	.	.	PUNCT
admet-2214	654	16	de	de	X
admet-2214	654	17	lange	lange	PROPN
admet-2214	654	18	,	,	PUNCT
admet-2214	654	19	m.	m.	NOUN
admet-2214	654	20	hammarlund	hammarlund	PROPN
admet-2214	654	21	-	-	PUNCT
admet-2214	654	22	udenaes	udenaes	PROPN
admet-2214	654	23	.	.	PUNCT
admet-2214	655	1	the	the	DET
admet-2214	655	2	impact	impact	NOUN
admet-2214	655	3	of	of	ADP
admet-2214	655	4	liposomal	liposomal	ADJ
admet-2214	655	5	formulations	formulation	NOUN
admet-2214	655	6	on	on	ADP
admet-2214	655	7	the	the	DET
admet-2214	655	8	release	release	NOUN
admet-2214	655	9	and	and	CCONJ
admet-2214	655	10	brain	brain	NOUN
admet-2214	655	11	delivery	delivery	NOUN
admet-2214	655	12	of	of	ADP
admet-2214	655	13	methotrexate	methotrexate	NOUN
admet-2214	655	14	:	:	PUNCT
admet-2214	655	15	an	an	DET
admet-2214	655	16	in	in	ADP
admet-2214	655	17	vivo	vivo	ADJ
admet-2214	655	18	microdialysis	microdialysis	NOUN
admet-2214	655	19	study	study	NOUN
admet-2214	655	20	.	.	PUNCT
admet-2214	656	1	journal	journal	NOUN
admet-2214	656	2	of	of	ADP
admet-2214	656	3	pharmaceutical	pharmaceutical	PROPN
admet-2214	656	4	sciences	science	NOUN
admet-2214	656	5	106	106	NUM
admet-2214	656	6	(	(	PUNCT
admet-2214	656	7	2017	2017	NUM
admet-2214	656	8	)	)	PUNCT
admet-2214	656	9	2606	2606	NUM
admet-2214	656	10	-	-	SYM
admet-2214	656	11	2613	2613	NUM
admet-2214	656	12	.	.	PUNCT
admet-2214	657	1	https://doi.org/10.1016/j.xphs.2017.03.009	https://doi.org/10.1016/j.xphs.2017.03.009	PROPN
admet-2214	657	2	[	[	X
admet-2214	657	3	68	68	NUM
admet-2214	657	4	]	]	PUNCT
admet-2214	657	5	a.m.	a.m.	NOUN
admet-2214	657	6	grabrucker	grabrucker	PROPN
admet-2214	657	7	,	,	PUNCT
admet-2214	657	8	b.	b.	PROPN
admet-2214	657	9	ruozi	ruozi	PROPN
admet-2214	657	10	,	,	PUNCT
admet-2214	657	11	d.	d.	PROPN
admet-2214	657	12	belletti	belletti	PROPN
admet-2214	657	13	,	,	PUNCT
admet-2214	657	14	f.	f.	PROPN
admet-2214	657	15	pederzoli	pederzoli	PROPN
admet-2214	657	16	,	,	PUNCT
admet-2214	657	17	f.	f.	PROPN
admet-2214	657	18	forni	forni	PROPN
admet-2214	657	19	,	,	PUNCT
admet-2214	657	20	m.a	m.a	PROPN
admet-2214	657	21	.	.	PROPN
admet-2214	657	22	vandelli	vandelli	PROPN
admet-2214	657	23	,	,	PUNCT
admet-2214	657	24	g.	g.	PROPN
admet-2214	657	25	tosi	tosi	PROPN
admet-2214	657	26	.	.	PUNCT
admet-2214	658	1	nanoparticle	nanoparticle	NOUN
admet-2214	658	2	transport	transport	NOUN
admet-2214	658	3	across	across	ADP
admet-2214	658	4	the	the	DET
admet-2214	658	5	blood	blood	NOUN
admet-2214	658	6	brain	brain	NOUN
admet-2214	658	7	barrier	barrier	NOUN
admet-2214	658	8	.	.	PUNCT
admet-2214	659	1	tissue	tissue	NOUN
admet-2214	659	2	barriers	barrier	NOUN
admet-2214	659	3	4	4	NUM
admet-2214	659	4	(	(	PUNCT
admet-2214	659	5	2016	2016	NUM
admet-2214	659	6	)	)	PUNCT
admet-2214	659	7	e1153568	e1153568	PROPN
admet-2214	659	8	.	.	PUNCT
admet-2214	659	9	https://doi.org/10.1080/21688370.2016.1153568	https://doi.org/10.1080/21688370.2016.1153568	PUNCT
admet-2214	660	1	[	[	X
admet-2214	660	2	69	69	NUM
admet-2214	660	3	]	]	PUNCT
admet-2214	660	4	t.	t.	PROPN
admet-2214	660	5	sasaki	sasaki	PROPN
admet-2214	660	6	,	,	PUNCT
admet-2214	660	7	j.	j.	PROPN
admet-2214	660	8	watanabe	watanabe	PROPN
admet-2214	660	9	,	,	PUNCT
admet-2214	660	10	x.	x.	PROPN
admet-2214	661	1	he	he	PRON
admet-2214	661	2	,	,	PUNCT
admet-2214	661	3	h.	h.	PROPN
admet-2214	661	4	katagi	katagi	PROPN
admet-2214	661	5	,	,	PUNCT
admet-2214	661	6	a.	a.	PROPN
admet-2214	661	7	suri	suri	PROPN
admet-2214	661	8	,	,	PUNCT
admet-2214	661	9	y.	y.	PROPN
admet-2214	661	10	ishi	ishi	PROPN
admet-2214	661	11	,	,	PUNCT
admet-2214	661	12	k.	k.	PROPN
admet-2214	661	13	abe	abe	PROPN
admet-2214	661	14	,	,	PUNCT
admet-2214	661	15	m.	m.	NOUN
admet-2214	661	16	natsumeda	natsumeda	PROPN
admet-2214	661	17	,	,	PUNCT
admet-2214	661	18	w.h	w.h	PROPN
admet-2214	661	19	.	.	PROPN
admet-2214	661	20	frey	frey	PROPN
admet-2214	661	21	,	,	PUNCT
admet-2214	661	22	p.	p.	PROPN
admet-2214	661	23	zhang	zhang	PROPN
admet-2214	661	24	,	,	PUNCT
admet-2214	661	25	r.	r.	PROPN
admet-2214	661	26	hashizume	hashizume	PROPN
admet-2214	661	27	.	.	PUNCT
admet-2214	662	1	intranasal	intranasal	ADJ
admet-2214	662	2	delivery	delivery	NOUN
admet-2214	662	3	of	of	ADP
admet-2214	662	4	nanoliposomal	nanoliposomal	ADJ
admet-2214	662	5	sn-38	sn-38	NOUN
admet-2214	662	6	for	for	ADP
admet-2214	662	7	treatment	treatment	NOUN
admet-2214	662	8	of	of	ADP
admet-2214	662	9	diffuse	diffuse	ADJ
admet-2214	662	10	midline	midline	NOUN
admet-2214	662	11	glioma	glioma	NOUN
admet-2214	662	12	.	.	PUNCT
admet-2214	663	1	journal	journal	NOUN
admet-2214	663	2	of	of	ADP
admet-2214	663	3	neurosurgery	neurosurgery	NOUN
admet-2214	663	4	138(6	138(6	NUM
admet-2214	663	5	)	)	PUNCT
admet-2214	663	6	(	(	PUNCT
admet-2214	663	7	2022	2022	NUM
admet-2214	663	8	)	)	PUNCT
admet-2214	663	9	1570–1579	1570–1579	NUM
admet-2214	663	10	.	.	PUNCT
admet-2214	664	1	https://doi.org/10.3171/2022.9.jns22715	https://doi.org/10.3171/2022.9.jns22715	NOUN
admet-2214	665	1	[	[	X
admet-2214	665	2	70	70	NUM
admet-2214	665	3	]	]	PUNCT
admet-2214	665	4	j.	j.	PROPN
admet-2214	665	5	clymer	clymer	PROPN
admet-2214	665	6	,	,	PUNCT
admet-2214	665	7	m.w	m.w	PROPN
admet-2214	665	8	.	.	PUNCT
admet-2214	665	9	kieran	kieran	PROPN
admet-2214	665	10	.	.	PUNCT
admet-2214	666	1	the	the	DET
admet-2214	666	2	integration	integration	NOUN
admet-2214	666	3	of	of	ADP
admet-2214	666	4	biology	biology	NOUN
admet-2214	666	5	into	into	ADP
admet-2214	666	6	the	the	DET
admet-2214	666	7	treatment	treatment	NOUN
admet-2214	666	8	of	of	ADP
admet-2214	666	9	diffuse	diffuse	NOUN
admet-2214	666	10	intrinsic	intrinsic	ADJ
admet-2214	666	11	pontine	pontine	ADJ
admet-2214	666	12	glioma	glioma	NOUN
admet-2214	666	13	:	:	PUNCT
admet-2214	666	14	a	a	DET
admet-2214	666	15	review	review	NOUN
admet-2214	666	16	of	of	ADP
admet-2214	666	17	the	the	DET
admet-2214	666	18	north	north	ADJ
admet-2214	666	19	american	american	ADJ
admet-2214	666	20	clinical	clinical	ADJ
admet-2214	666	21	trial	trial	NOUN
admet-2214	666	22	perspective	perspective	NOUN
admet-2214	666	23	.	.	PUNCT
admet-2214	667	1	frontiers	frontier	NOUN
admet-2214	667	2	in	in	ADP
admet-2214	667	3	oncology	oncology	NOUN
admet-2214	667	4	8	8	NUM
admet-2214	667	5	(	(	PUNCT
admet-2214	667	6	2018	2018	NUM
admet-2214	667	7	)	)	PUNCT
admet-2214	667	8	169	169	NUM
admet-2214	667	9	.	.	PUNCT
admet-2214	668	1	https://doi.org/10.3389/fonc.2018.00169	https://doi.org/10.3389/fonc.2018.00169	PROPN
admet-2214	669	1	[	[	X
admet-2214	669	2	71	71	NUM
admet-2214	669	3	]	]	X
admet-2214	669	4	n.e	n.e	PROPN
admet-2214	669	5	.	.	PROPN
admet-2214	669	6	helwig	helwig	PROPN
admet-2214	669	7	,	,	PUNCT
admet-2214	669	8	s.	s.	PROPN
admet-2214	669	9	hong	hong	PROPN
admet-2214	669	10	,	,	PUNCT
admet-2214	669	11	e.t	e.t	PROPN
admet-2214	669	12	.	.	PROPN
admet-2214	670	1	hsiao	hsiao	PROPN
admet-2214	670	2	-	-	NOUN
admet-2214	670	3	wecksler	wecksler	NOUN
admet-2214	670	4	.	.	PUNCT
admet-2214	671	1	d	d	X
admet-2214	671	2	-	-	PUNCT
admet-2214	671	3	limonene	limonene	NOUN
admet-2214	671	4	-	-	PUNCT
admet-2214	671	5	loaded	load	VERB
admet-2214	671	6	liposomes	liposome	NOUN
admet-2214	671	7	target	target	VERB
admet-2214	671	8	malignant	malignant	ADJ
admet-2214	671	9	glioma	glioma	NOUN
admet-2214	671	10	cells	cell	NOUN
admet-2214	671	11	via	via	ADP
admet-2214	671	12	the	the	DET
admet-2214	671	13	downregulation	downregulation	NOUN
admet-2214	671	14	of	of	ADP
admet-2214	671	15	angiogenic	angiogenic	ADJ
admet-2214	671	16	growth	growth	NOUN
admet-2214	671	17	factors	factor	NOUN
admet-2214	671	18	.	.	PUNCT
admet-2214	672	1	journal	journal	NOUN
admet-2214	672	2	of	of	ADP
admet-2214	672	3	drug	drug	NOUN
admet-2214	672	4	delivery	delivery	NOUN
admet-2214	672	5	science	science	NOUN
admet-2214	672	6	and	and	CCONJ
admet-2214	672	7	technology	technology	NOUN
admet-2214	672	8	82	82	NUM
admet-2214	672	9	(	(	PUNCT
admet-2214	672	10	2023	2023	NUM
admet-2214	672	11	)	)	PUNCT
admet-2214	672	12	104358	104358	NUM
admet-2214	672	13	.	.	PUNCT
admet-2214	673	1	https://doi.org/10.1016/j.jddst.2023.104358	https://doi.org/10.1016/j.jddst.2023.104358	NOUN
admet-2214	674	1	[	[	X
admet-2214	674	2	72	72	X
admet-2214	674	3	]	]	X
admet-2214	674	4	v.	v.	ADP
admet-2214	674	5	é	é	PROPN
admet-2214	674	6	.	.	PUNCT
admet-2214	674	7	berberine	berberine	PROPN
admet-2214	674	8	and	and	CCONJ
admet-2214	674	9	folic	folic	NOUN
admet-2214	674	10	acid	acid	NOUN
admet-2214	674	11	co	co	VERB
admet-2214	674	12	-	-	ADJ
admet-2214	674	13	modified	modify	VERB
admet-2214	674	14	ph	ph	ADJ
admet-2214	674	15	-	-	ADJ
admet-2214	674	16	sensitive	sensitive	ADJ
admet-2214	674	17	cascade	cascade	NOUN
admet-2214	674	18	-	-	PUNCT
admet-2214	674	19	targeted	target	VERB
admet-2214	674	20	ptx	ptx	NOUN
admet-2214	674	21	-	-	PUNCT
admet-2214	674	22	liposomes	liposome	NOUN
admet-2214	674	23	coated	coat	VERB
admet-2214	674	24	with	with	ADP
admet-2214	674	25	tween	tween	NOUN
admet-2214	674	26	80	80	NUM
admet-2214	674	27	for	for	ADP
admet-2214	674	28	treating	treat	VERB
admet-2214	674	29	glioma	glioma	NOUN
admet-2214	674	30	.	.	PUNCT
admet-2214	675	1	bioorganic	bioorganic	PROPN
admet-2214	675	2	&	&	CCONJ
admet-2214	675	3	medicinal	medicinal	ADJ
admet-2214	675	4	chemistry	chemistry	NOUN
admet-2214	675	5	69	69	NUM
admet-2214	675	6	(	(	PUNCT
admet-2214	675	7	2022	2022	NUM
admet-2214	675	8	)	)	PUNCT
admet-2214	675	9	185	185	NUM
admet-2214	675	10	-	-	SYM
admet-2214	675	11	198	198	NUM
admet-2214	675	12	.	.	PUNCT
admet-2214	676	1	https://doi.org/10.1016/j.bmc.2022.116893	https://doi.org/10.1016/j.bmc.2022.116893	PUNCT
admet-2214	677	1	[	[	X
admet-2214	677	2	73	73	NUM
admet-2214	677	3	]	]	X
admet-2214	677	4	n.e	n.e	PROPN
admet-2214	677	5	.	.	PROPN
admet-2214	677	6	helwig	helwig	PROPN
admet-2214	677	7	,	,	PUNCT
admet-2214	677	8	s.	s.	PROPN
admet-2214	677	9	hong	hong	PROPN
admet-2214	677	10	,	,	PUNCT
admet-2214	677	11	e.t	e.t	PROPN
admet-2214	677	12	.	.	PROPN
admet-2214	677	13	hsiao	hsiao	PROPN
admet-2214	677	14	-	-	PUNCT
admet-2214	677	15	wecksler	wecksler	NOUN
admet-2214	677	16	.	.	PUNCT
admet-2214	677	17	synthesis	synthesis	NOUN
admet-2214	677	18	and	and	CCONJ
admet-2214	677	19	evaluation	evaluation	NOUN
admet-2214	677	20	of	of	ADP
admet-2214	677	21	high	high	ADJ
admet-2214	677	22	functionality	functionality	NOUN
admet-2214	677	23	and	and	CCONJ
admet-2214	677	24	quality	quality	NOUN
admet-2214	677	25	cell	cell	NOUN
admet-2214	677	26	-	-	PUNCT
admet-2214	677	27	penetrating	penetrate	VERB
admet-2214	677	28	peptide	peptide	NOUN
admet-2214	677	29	conjugated	conjugate	VERB
admet-2214	677	30	lipid	lipid	NOUN
admet-2214	677	31	for	for	ADP
admet-2214	677	32	octaarginine	octaarginine	NOUN
admet-2214	677	33	modified	modify	VERB
admet-2214	677	34	pegylated	pegylate	VERB
admet-2214	677	35	liposomes	liposome	NOUN
admet-2214	677	36	in	in	ADP
admet-2214	677	37	u251	u251	PROPN
admet-2214	677	38	and	and	CCONJ
admet-2214	677	39	u87	u87	ADJ
admet-2214	677	40	glioma	glioma	NOUN
admet-2214	677	41	cells	cell	NOUN
admet-2214	677	42	.	.	PUNCT
admet-2214	678	1	journal	journal	NOUN
admet-2214	678	2	of	of	ADP
admet-2214	678	3	pharmaceutical	pharmaceutical	PROPN
admet-2214	678	4	sciences	science	NOUN
admet-2214	678	5	111	111	NUM
admet-2214	678	6	(	(	PUNCT
admet-2214	678	7	2022	2022	NUM
admet-2214	678	8	)	)	PUNCT
admet-2214	678	9	1719	1719	NUM
admet-2214	678	10	-	-	SYM
admet-2214	678	11	1727	1727	NUM
admet-2214	678	12	.	.	PUNCT
admet-2214	679	1	https://doi.org/10.1016/j.xphs.2021.11.022	https://doi.org/10.1016/j.xphs.2021.11.022	NOUN
admet-2214	679	2	[	[	X
admet-2214	679	3	74	74	NUM
admet-2214	679	4	]	]	X
admet-2214	679	5	b.s	b.s	PROPN
admet-2214	679	6	.	.	PROPN
admet-2214	679	7	3	3	NUM
admet-2214	679	8	muhammad	muhammad	PROPN
admet-2214	679	9	ismail	ismail	PROPN
admet-2214	679	10	1	1	NUM
admet-2214	679	11	,	,	PUNCT
admet-2214	679	12	wen	wen	PROPN
admet-2214	679	13	yang	yang	PROPN
admet-2214	679	14	1	1	NUM
admet-2214	679	15	,	,	PUNCT
admet-2214	679	16	yanfei	yanfei	PROPN
admet-2214	679	17	li	li	PROPN
admet-2214	679	18	1	1	NUM
admet-2214	679	19	,	,	PUNCT
admet-2214	679	20	tianran	tianran	VERB
admet-2214	679	21	chai	chai	NOUN
admet-2214	679	22	1	1	NUM
admet-2214	679	23	,	,	PUNCT
admet-2214	679	24	dongya	dongya	NOUN
admet-2214	679	25	zhang	zhang	PROPN
admet-2214	679	26	1	1	NUM
admet-2214	679	27	,	,	PUNCT
admet-2214	679	28	qiuli	qiuli	X
admet-2214	679	29	du	du	PROPN
admet-2214	679	30	1	1	NUM
admet-2214	679	31	,	,	PUNCT
admet-2214	679	32	pir	pir	PROPN
admet-2214	679	33	muhammad	muhammad	PROPN
admet-2214	679	34	1	1	NUM
admet-2214	679	35	,	,	PUNCT
admet-2214	679	36	sumaira	sumaira	PROPN
admet-2214	679	37	hanif	hanif	PROPN
admet-2214	679	38	1	1	NUM
admet-2214	679	39	,	,	PUNCT
admet-2214	679	40	meng	meng	PROPN
admet-2214	679	41	zheng	zheng	PROPN
admet-2214	679	42	2	2	X
admet-2214	679	43	.	.	NUM
admet-2214	679	44	targeted	target	VERB
admet-2214	679	45	liposomes	liposome	NOUN
admet-2214	679	46	for	for	ADP
admet-2214	679	47	combined	combined	ADJ
admet-2214	679	48	delivery	delivery	NOUN
admet-2214	679	49	of	of	ADP
admet-2214	679	50	artesunate	artesunate	NOUN
admet-2214	679	51	and	and	CCONJ
admet-2214	679	52	temozolomide	temozolomide	NOUN
admet-2214	679	53	to	to	ADP
admet-2214	679	54	resistant	resistant	ADJ
admet-2214	679	55	glioblastoma	glioblastoma	NOUN
admet-2214	679	56	.	.	PUNCT
admet-2214	680	1	biomaterials	biomaterial	NOUN
admet-2214	680	2	287	287	NUM
admet-2214	680	3	(	(	PUNCT
admet-2214	680	4	2022	2022	NUM
admet-2214	680	5	)	)	PUNCT
admet-2214	680	6	121608	121608	NUM
admet-2214	680	7	.	.	PUNCT
admet-2214	681	1	https://doi.org/10.1016/j.biomaterials.2022.121608	https://doi.org/10.1016/j.biomaterials.2022.121608	PROPN
admet-2214	681	2	[	[	X
admet-2214	681	3	75	75	NUM
admet-2214	681	4	]	]	X
admet-2214	681	5	n.	n.	NOUN
admet-2214	681	6	dhiman	dhiman	NOUN
admet-2214	681	7	,	,	PUNCT
admet-2214	681	8	r.	r.	PROPN
admet-2214	681	9	awasthi	awasthi	PROPN
admet-2214	681	10	,	,	PUNCT
admet-2214	681	11	b.	b.	PROPN
admet-2214	681	12	sharma	sharma	PROPN
admet-2214	681	13	,	,	PUNCT
admet-2214	681	14	h.	h.	PROPN
admet-2214	681	15	kharkwal	kharkwal	PROPN
admet-2214	681	16	,	,	PUNCT
admet-2214	681	17	g.t	g.t	PROPN
admet-2214	681	18	.	.	PROPN
admet-2214	681	19	kulkarni	kulkarni	PROPN
admet-2214	681	20	.	.	PUNCT
admet-2214	682	1	lipid	lipid	PROPN
admet-2214	682	2	nanoparticles	nanoparticle	NOUN
admet-2214	682	3	as	as	ADP
admet-2214	682	4	carriers	carrier	NOUN
admet-2214	682	5	for	for	ADP
admet-2214	682	6	bioactive	bioactive	ADJ
admet-2214	682	7	delivery	delivery	NOUN
admet-2214	682	8	.	.	PUNCT
admet-2214	683	1	frontiers	frontier	NOUN
admet-2214	683	2	in	in	ADP
admet-2214	683	3	chemistry	chemistry	NOUN
admet-2214	683	4	9	9	NUM
admet-2214	683	5	(	(	PUNCT
admet-2214	683	6	2021	2021	NUM
admet-2214	683	7	)	)	PUNCT
admet-2214	683	8	580118	580118	NUM
admet-2214	683	9	.	.	PUNCT
admet-2214	684	1	https://doi.org/10.3389/fchem.2021.580118	https://doi.org/10.3389/fchem.2021.580118	PROPN
admet-2214	685	1	[	[	X
admet-2214	685	2	76	76	NUM
admet-2214	685	3	]	]	PUNCT
admet-2214	685	4	k.	k.	PROPN
admet-2214	685	5	westesen	westesen	PROPN
admet-2214	685	6	,	,	PUNCT
admet-2214	685	7	h.	h.	PROPN
admet-2214	685	8	bunjes	bunjes	PROPN
admet-2214	685	9	.	.	PUNCT
admet-2214	686	1	do	do	AUX
admet-2214	686	2	nanoparticles	nanoparticle	NOUN
admet-2214	686	3	prepared	prepare	VERB
admet-2214	686	4	from	from	ADP
admet-2214	686	5	lipids	lipid	NOUN
admet-2214	686	6	solid	solid	ADJ
admet-2214	686	7	at	at	ADP
admet-2214	686	8	room	room	NOUN
admet-2214	686	9	temperature	temperature	NOUN
admet-2214	686	10	always	always	ADV
admet-2214	686	11	possess	possess	VERB
admet-2214	686	12	a	a	DET
admet-2214	686	13	solid	solid	ADJ
admet-2214	686	14	lipid	lipid	NOUN
admet-2214	686	15	matrix	matrix	NOUN
admet-2214	686	16	?	?	PUNCT
admet-2214	687	1	international	international	ADJ
admet-2214	687	2	journal	journal	NOUN
admet-2214	687	3	of	of	ADP
admet-2214	687	4	pharmaceutics	pharmaceutic	NOUN
admet-2214	687	5	115	115	NUM
admet-2214	687	6	(	(	PUNCT
admet-2214	687	7	1995	1995	NUM
admet-2214	687	8	)	)	PUNCT
admet-2214	687	9	129	129	NUM
admet-2214	687	10	-	-	SYM
admet-2214	687	11	131	131	NUM
admet-2214	687	12	.	.	PUNCT
admet-2214	688	1	https://doi.org/10.1016/0378-5173(94)00347-8	https://doi.org/10.1016/0378-5173(94)00347-8	PROPN
admet-2214	688	2	[	[	X
admet-2214	688	3	77	77	NUM
admet-2214	688	4	]	]	X
admet-2214	688	5	n.	n.	PROPN
admet-2214	688	6	naseri	naseri	PROPN
admet-2214	688	7	,	,	PUNCT
admet-2214	688	8	h.	h.	PROPN
admet-2214	688	9	valizadeh	valizadeh	PROPN
admet-2214	688	10	,	,	PUNCT
admet-2214	688	11	p.	p.	PROPN
admet-2214	688	12	zakeri	zakeri	PROPN
admet-2214	688	13	-	-	PROPN
admet-2214	688	14	milani	milani	PROPN
admet-2214	688	15	.	.	PUNCT
admet-2214	689	1	solid	solid	ADJ
admet-2214	689	2	lipid	lipid	ADJ
admet-2214	689	3	nanoparticles	nanoparticle	NOUN
admet-2214	689	4	and	and	CCONJ
admet-2214	689	5	nanostructured	nanostructure	VERB
admet-2214	689	6	lipid	lipid	NOUN
admet-2214	689	7	carriers	carrier	NOUN
admet-2214	689	8	:	:	PUNCT
admet-2214	689	9	structure	structure	NOUN
admet-2214	689	10	preparation	preparation	NOUN
admet-2214	689	11	and	and	CCONJ
admet-2214	689	12	application	application	NOUN
admet-2214	689	13	.	.	PUNCT
admet-2214	690	1	advanced	advanced	ADJ
admet-2214	690	2	pharmaceutical	pharmaceutical	ADJ
admet-2214	690	3	bulletin	bulletin	NOUN
admet-2214	690	4	5	5	NUM
admet-2214	690	5	(	(	PUNCT
admet-2214	690	6	2015	2015	NUM
admet-2214	690	7	)	)	PUNCT
admet-2214	690	8	305	305	NUM
admet-2214	690	9	-	-	SYM
admet-2214	690	10	313	313	NUM
admet-2214	690	11	https://doi.org/10.15171/apb.2015.043	https://doi.org/10.15171/apb.2015.043	PROPN
admet-2214	690	12	[	[	X
admet-2214	690	13	78	78	NUM
admet-2214	690	14	]	]	X
admet-2214	690	15	y.	y.	PROPN
admet-2214	690	16	dong	dong	PROPN
admet-2214	690	17	,	,	PUNCT
admet-2214	690	18	w.k	w.k	PROPN
admet-2214	690	19	.	.	PROPN
admet-2214	690	20	ng	ng	PROPN
admet-2214	690	21	,	,	PUNCT
admet-2214	690	22	s.	s.	PROPN
admet-2214	690	23	shen	shen	PROPN
admet-2214	690	24	,	,	PUNCT
admet-2214	690	25	s.	s.	PROPN
admet-2214	690	26	kim	kim	PROPN
admet-2214	690	27	,	,	PUNCT
admet-2214	690	28	r.b.h	r.b.h	PROPN
admet-2214	690	29	.	.	PUNCT
admet-2214	690	30	tan	tan	PROPN
admet-2214	690	31	.	.	PUNCT
admet-2214	691	1	solid	solid	ADJ
admet-2214	691	2	lipid	lipid	ADJ
admet-2214	691	3	nanoparticles	nanoparticle	NOUN
admet-2214	691	4	:	:	PUNCT
admet-2214	691	5	continuous	continuous	ADJ
admet-2214	691	6	and	and	CCONJ
admet-2214	691	7	potential	potential	ADJ
admet-2214	691	8	large	large	ADJ
admet-2214	691	9	-	-	PUNCT
admet-2214	691	10	scale	scale	NOUN
admet-2214	691	11	nanoprecipitation	nanoprecipitation	NOUN
admet-2214	691	12	production	production	NOUN
admet-2214	691	13	in	in	ADP
admet-2214	691	14	static	static	ADJ
admet-2214	691	15	mixers	mixer	NOUN
admet-2214	691	16	.	.	PUNCT
admet-2214	692	1	colloids	colloid	NOUN
admet-2214	692	2	and	and	CCONJ
admet-2214	692	3	surfaces	surface	NOUN
admet-2214	692	4	b	b	PROPN
admet-2214	692	5	94	94	NUM
admet-2214	692	6	(	(	PUNCT
admet-2214	692	7	2012	2012	NUM
admet-2214	692	8	)	)	PUNCT
admet-2214	692	9	68	68	NUM
admet-2214	692	10	-	-	SYM
admet-2214	692	11	72	72	NUM
admet-2214	692	12	.	.	PUNCT
admet-2214	693	1	https://doi.org/10.1016/j.colsurfb.2012.01.018	https://doi.org/10.1016/j.colsurfb.2012.01.018	NUM
admet-2214	693	2	[	[	X
admet-2214	693	3	79	79	NUM
admet-2214	693	4	]	]	SYM
admet-2214	693	5	v.h.s	v.h.s	NOUN
admet-2214	693	6	.	.	PUNCT
admet-2214	694	1	araujo	araujo	PROPN
admet-2214	694	2	,	,	PUNCT
admet-2214	694	3	l.	l.	PROPN
admet-2214	694	4	delello	delello	PROPN
admet-2214	694	5	di	di	PROPN
admet-2214	694	6	filippo	filippo	PROPN
admet-2214	694	7	,	,	PUNCT
admet-2214	694	8	j.l	j.l	PROPN
admet-2214	694	9	.	.	PROPN
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admet-2214	694	11	,	,	PUNCT
admet-2214	694	12	l.	l.	PROPN
admet-2214	694	13	spósito	spósito	PROPN
admet-2214	694	14	,	,	PUNCT
admet-2214	694	15	b.a.f	b.a.f	PROPN
admet-2214	694	16	.	.	PUNCT
admet-2214	695	1	de	de	PROPN
admet-2214	695	2	camargo	camargo	PROPN
admet-2214	695	3	,	,	PUNCT
admet-2214	695	4	p.b	p.b	PROPN
admet-2214	695	5	.	.	PROPN
admet-2214	695	6	da	da	PROPN
admet-2214	695	7	silva	silva	PROPN
admet-2214	695	8	,	,	PUNCT
admet-2214	695	9	m.	m.	NOUN
admet-2214	695	10	chorilli	chorilli	PROPN
admet-2214	695	11	.	.	PUNCT
admet-2214	696	1	exploiting	exploit	VERB
admet-2214	696	2	solid	solid	ADJ
admet-2214	696	3	lipid	lipid	ADJ
admet-2214	696	4	nanoparticles	nanoparticle	NOUN
admet-2214	696	5	and	and	CCONJ
admet-2214	696	6	nanostructured	nanostructure	VERB
admet-2214	696	7	lipid	lipid	NOUN
admet-2214	696	8	carriers	carrier	NOUN
admet-2214	696	9	for	for	ADP
admet-2214	696	10	drug	drug	NOUN
admet-2214	696	11	delivery	delivery	NOUN
admet-2214	696	12	against	against	ADP
admet-2214	696	13	cutaneous	cutaneous	ADJ
admet-2214	696	14	fungal	fungal	ADJ
admet-2214	696	15	infections	infection	NOUN
admet-2214	696	16	.	.	PUNCT
admet-2214	697	1	critical	critical	ADJ
admet-2214	697	2	reviews	review	NOUN
admet-2214	697	3	in	in	ADP
admet-2214	697	4	microbiology	microbiology	NOUN
admet-2214	697	5	47	47	NUM
admet-2214	697	6	(	(	PUNCT
admet-2214	697	7	2021	2021	NUM
admet-2214	697	8	)	)	PUNCT
admet-2214	697	9	79	79	NUM
admet-2214	697	10	-	-	SYM
admet-2214	697	11	90	90	NUM
admet-2214	697	12	.	.	PUNCT
admet-2214	698	1	https://doi.org/10.1080/1040841x.2020.1843399	https://doi.org/10.1080/1040841x.2020.1843399	VERB
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admet-2214	698	5	https://doi.org/10.3389/fonc.2018.00169	https://doi.org/10.3389/fonc.2018.00169	PROPN
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admet-2214	698	7	https://doi.org/10.1016/j.bmc.2022.116893	https://doi.org/10.1016/j.bmc.2022.116893	PROPN
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admet-2214	698	9	https://doi.org/10.1016/j.biomaterials.2022.121608	https://doi.org/10.1016/j.biomaterials.2022.121608	NOUN
admet-2214	698	10	https://doi.org/10.3389/fchem.2021.580118	https://doi.org/10.3389/fchem.2021.580118	PROPN
admet-2214	699	1	https://doi.org/10.1016/0378-5173(94)00347-8	https://doi.org/10.1016/0378-5173(94)00347-8	PROPN
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admet-2214	699	3	https://doi.org/10.1016/j.colsurfb.2012.01.018	https://doi.org/10.1016/j.colsurfb.2012.01.018	PROPN
admet-2214	699	4	https://doi.org/10.1080/1040841x.2020.1843399	https://doi.org/10.1080/1040841x.2020.1843399	NOUN
admet-2214	699	5	admet	admet	X
admet-2214	699	6	&	&	CCONJ
admet-2214	699	7	dmpk	dmpk	PROPN
admet-2214	699	8	12(3	12(3	PROPN
admet-2214	699	9	)	)	PUNCT
admet-2214	699	10	(	(	PUNCT
admet-2214	699	11	2024	2024	NUM
admet-2214	699	12	)	)	PUNCT
admet-2214	699	13	403	403	NUM
admet-2214	699	14	-	-	SYM
admet-2214	699	15	429	429	NUM
admet-2214	699	16	addressing	address	VERB
admet-2214	699	17	barriers	barrier	NOUN
admet-2214	699	18	in	in	ADP
admet-2214	699	19	diffuse	diffuse	ADJ
admet-2214	699	20	intrinsic	intrinsic	ADJ
admet-2214	699	21	pontine	pontine	ADJ
admet-2214	699	22	glioma	glioma	NOUN
admet-2214	699	23	doi	doi	NOUN
admet-2214	699	24	:	:	PUNCT
admet-2214	699	25	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	X
admet-2214	699	26	427	427	NUM
admet-2214	700	1	[	[	SYM
admet-2214	700	2	80	80	NUM
admet-2214	700	3	]	]	X
admet-2214	700	4	s.	s.	PROPN
admet-2214	700	5	mukherjee	mukherjee	PROPN
admet-2214	700	6	,	,	PUNCT
admet-2214	700	7	s.	s.	PROPN
admet-2214	700	8	ray	ray	PROPN
admet-2214	700	9	,	,	PUNCT
admet-2214	700	10	r.s	r.s	PROPN
admet-2214	700	11	.	.	PROPN
admet-2214	700	12	thakur	thakur	PROPN
admet-2214	700	13	.	.	PUNCT
admet-2214	701	1	solid	solid	ADJ
admet-2214	701	2	lipid	lipid	ADJ
admet-2214	701	3	nanoparticles	nanoparticle	NOUN
admet-2214	701	4	:	:	PUNCT
admet-2214	701	5	a	a	DET
admet-2214	701	6	modern	modern	ADJ
admet-2214	701	7	formulation	formulation	NOUN
admet-2214	701	8	approach	approach	NOUN
admet-2214	701	9	in	in	ADP
admet-2214	701	10	drug	drug	NOUN
admet-2214	701	11	delivery	delivery	NOUN
admet-2214	701	12	system	system	NOUN
admet-2214	701	13	.	.	PUNCT
admet-2214	702	1	indian	indian	PROPN
admet-2214	702	2	journal	journal	PROPN
admet-2214	702	3	of	of	ADP
admet-2214	702	4	pharmceutical	pharmceutical	ADJ
admet-2214	702	5	science	science	NOUN
admet-2214	702	6	71(4	71(4	NUM
admet-2214	702	7	)	)	PUNCT
admet-2214	702	8	(	(	PUNCT
admet-2214	702	9	2009	2009	NUM
admet-2214	702	10	)	)	PUNCT
admet-2214	702	11	349	349	NUM
admet-2214	702	12	.	.	PUNCT
admet-2214	703	1	https://doi.org/10.4103/0250-474x.57282	https://doi.org/10.4103/0250-474x.57282	PROPN
admet-2214	703	2	[	[	X
admet-2214	703	3	81	81	NUM
admet-2214	703	4	]	]	X
admet-2214	703	5	g.	g.	PROPN
admet-2214	703	6	ak	ak	PROPN
admet-2214	703	7	,	,	PUNCT
admet-2214	703	8	a.	a.	NOUN
admet-2214	703	9	ünal	ünal	NOUN
admet-2214	703	10	,	,	PUNCT
admet-2214	703	11	t.	t.	PROPN
admet-2214	703	12	karakayalı	karakayalı	PROPN
admet-2214	703	13	,	,	PUNCT
admet-2214	703	14	b.	b.	PROPN
admet-2214	703	15	özel	özel	PROPN
admet-2214	703	16	,	,	PUNCT
admet-2214	703	17	n.	n.	PROPN
admet-2214	703	18	selvi	selvi	PROPN
admet-2214	703	19	günel	günel	PROPN
admet-2214	703	20	,	,	PUNCT
admet-2214	703	21	ş	ş	X
admet-2214	703	22	.	.	PUNCT
admet-2214	704	1	hamarat	hamarat	PROPN
admet-2214	704	2	şanlıer	şanlıer	PROPN
admet-2214	704	3	.	.	PUNCT
admet-2214	705	1	brain	brain	NOUN
admet-2214	705	2	-	-	PUNCT
admet-2214	705	3	targeted	target	VERB
admet-2214	705	4	,	,	PUNCT
admet-2214	705	5	drug	drug	NOUN
admet-2214	705	6	-	-	PUNCT
admet-2214	705	7	loaded	load	VERB
admet-2214	705	8	solid	solid	ADJ
admet-2214	705	9	lipid	lipid	NOUN
admet-2214	705	10	nanoparticles	nanoparticle	NOUN
admet-2214	705	11	against	against	ADP
admet-2214	705	12	glioblastoma	glioblastoma	NOUN
admet-2214	705	13	cells	cell	NOUN
admet-2214	705	14	in	in	ADP
admet-2214	705	15	culture	culture	NOUN
admet-2214	705	16	.	.	PUNCT
admet-2214	706	1	colloids	colloid	NOUN
admet-2214	706	2	and	and	CCONJ
admet-2214	706	3	surfaces	surface	NOUN
admet-2214	706	4	b	b	NUM
admet-2214	706	5	:	:	PUNCT
admet-2214	706	6	biointerfaces	biointerface	NOUN
admet-2214	706	7	206	206	NUM
admet-2214	706	8	(	(	PUNCT
admet-2214	706	9	2021	2021	NUM
admet-2214	706	10	)	)	PUNCT
admet-2214	706	11	111946	111946	NUM
admet-2214	706	12	.	.	PUNCT
admet-2214	707	1	https://doi.org/10.1016/j.colsurfb.2021.111946	https://doi.org/10.1016/j.colsurfb.2021.111946	NOUN
admet-2214	707	2	[	[	X
admet-2214	707	3	82	82	NUM
admet-2214	707	4	]	]	X
admet-2214	707	5	j.i.d.s	j.i.d.s	PROPN
admet-2214	707	6	.	.	PROPN
admet-2214	707	7	alexandre	alexandre	PROPN
admet-2214	707	8	,	,	PUNCT
admet-2214	707	9	s.m.d	s.m.d	PROPN
admet-2214	707	10	.	.	PUNCT
admet-2214	708	1	santos	santos	PROPN
admet-2214	708	2	neto	neto	PROPN
admet-2214	708	3	,	,	PUNCT
admet-2214	708	4	a.p	a.p	PROPN
admet-2214	708	5	.	.	PROPN
admet-2214	708	6	coutinho	coutinho	PROPN
admet-2214	708	7	,	,	PUNCT
admet-2214	708	8	t.d.a.t.d	t.d.a.t.d	PROPN
admet-2214	708	9	.	.	PUNCT
admet-2214	709	1	melo	melo	PROPN
admet-2214	709	2	,	,	PUNCT
admet-2214	709	3	,	,	PUNCT
admet-2214	709	4	e.a.p	e.a.p	PROPN
admet-2214	709	5	.	.	PROPN
admet-2214	709	6	gonçalves	gonçalves	PROPN
admet-2214	709	7	,	,	PUNCT
admet-2214	709	8	m.v.s	m.v.s	PROPN
admet-2214	709	9	.	.	PROPN
admet-2214	709	10	gondim	gondim	PROPN
admet-2214	709	11	,	,	PUNCT
admet-2214	709	12	a.c.d	a.c.d	NOUN
admet-2214	709	13	.	.	PUNCT
admet-2214	709	14	antonino	antonino	PROPN
admet-2214	709	15	,	,	PUNCT
admet-2214	709	16	a.e.c.d.g.d.c	a.e.c.d.g.d.c	PROPN
admet-2214	709	17	.	.	PUNCT
admet-2214	710	1	rabelo	rabelo	NOUN
admet-2214	710	2	,	,	PUNCT
admet-2214	710	3	a.l.d	a.l.d	NOUN
admet-2214	710	4	.	.	PUNCT
admet-2214	711	1	oliveira	oliveira	PROPN
admet-2214	711	2	.	.	PUNCT
admet-2214	712	1	sorption	sorption	NOUN
admet-2214	712	2	of	of	ADP
admet-2214	712	3	the	the	DET
admet-2214	712	4	direct	direct	ADJ
admet-2214	712	5	black	black	ADJ
admet-2214	712	6	22	22	NUM
admet-2214	712	7	dye	dye	NOUN
admet-2214	712	8	in	in	ADP
admet-2214	712	9	alluvial	alluvial	ADJ
admet-2214	712	10	soil	soil	NOUN
admet-2214	712	11	.	.	PUNCT
admet-2214	713	1	revista	revista	PROPN
admet-2214	713	2	ambiente	ambiente	PROPN
admet-2214	713	3	&	&	CCONJ
admet-2214	713	4	água	água	PROPN
admet-2214	713	5	,	,	PUNCT
admet-2214	713	6	15	15	NUM
admet-2214	713	7	(	(	PUNCT
admet-2214	713	8	2020	2020	NUM
admet-2214	713	9	)	)	PUNCT
admet-2214	714	1	e2483	e2483	NOUN
admet-2214	714	2	.	.	PUNCT
admet-2214	714	3	https://doi.org/10.4136/ambi-agua.2483	https://doi.org/10.4136/ambi-agua.2483	NOUN
admet-2214	715	1	[	[	X
admet-2214	715	2	83	83	NUM
admet-2214	715	3	]	]	X
admet-2214	715	4	s.	s.	PROPN
admet-2214	715	5	wang	wang	PROPN
admet-2214	715	6	,	,	PUNCT
admet-2214	715	7	t.	t.	PROPN
admet-2214	715	8	chen	chen	PROPN
admet-2214	715	9	,	,	PUNCT
admet-2214	715	10	r.	r.	PROPN
admet-2214	715	11	chen	chen	PROPN
admet-2214	715	12	,	,	PUNCT
admet-2214	715	13	y.	y.	PROPN
admet-2214	715	14	hu	hu	PROPN
admet-2214	715	15	,	,	PUNCT
admet-2214	715	16	m.	m.	PROPN
admet-2214	715	17	chen	chen	PROPN
admet-2214	715	18	,	,	PUNCT
admet-2214	715	19	y.	y.	PROPN
admet-2214	715	20	wang	wang	PROPN
admet-2214	715	21	.	.	PUNCT
admet-2214	716	1	emodin	emodin	AUX
admet-2214	716	2	loaded	load	VERB
admet-2214	716	3	solid	solid	ADJ
admet-2214	716	4	lipid	lipid	NOUN
admet-2214	716	5	nanoparticles	nanoparticle	NOUN
admet-2214	716	6	:	:	PUNCT
admet-2214	716	7	preparation	preparation	NOUN
admet-2214	716	8	,	,	PUNCT
admet-2214	716	9	characterization	characterization	NOUN
admet-2214	716	10	and	and	CCONJ
admet-2214	716	11	antitumor	antitumor	NOUN
admet-2214	716	12	activity	activity	NOUN
admet-2214	716	13	studies	study	NOUN
admet-2214	716	14	.	.	PUNCT
admet-2214	717	1	international	international	ADJ
admet-2214	717	2	journal	journal	PROPN
admet-2214	717	3	of	of	ADP
admet-2214	717	4	pharmaceutics	pharmaceutic	NOUN
admet-2214	717	5	430	430	NUM
admet-2214	717	6	(	(	PUNCT
admet-2214	717	7	2012	2012	NUM
admet-2214	717	8	)	)	PUNCT
admet-2214	717	9	238	238	NUM
admet-2214	717	10	-	-	SYM
admet-2214	717	11	246	246	NUM
admet-2214	717	12	.	.	PUNCT
admet-2214	718	1	https://doi.org/10.1016/j.ijpharm.2012.03.027	https://doi.org/10.1016/j.ijpharm.2012.03.027	PRON
admet-2214	718	2	[	[	X
admet-2214	718	3	84	84	NUM
admet-2214	718	4	]	]	PUNCT
admet-2214	718	5	v.s.	v.s.	ADJ
admet-2214	718	6	1	1	NUM
admet-2214	718	7	priyanka	priyanka	PROPN
admet-2214	718	8	jain	jain	PROPN
admet-2214	718	9	1	1	NUM
admet-2214	718	10	,	,	PUNCT
admet-2214	718	11	vikas	vikas	NOUN
admet-2214	718	12	pandey	pandey	PROPN
admet-2214	718	13	1	1	PROPN
admet-2214	718	14	.	.	PUNCT
admet-2214	718	15	bioconjugate	bioconjugate	NOUN
admet-2214	718	16	-	-	PUNCT
admet-2214	718	17	loaded	load	VERB
admet-2214	718	18	solid	solid	ADJ
admet-2214	718	19	lipid	lipid	NOUN
admet-2214	718	20	nanoparticles	nanoparticle	NOUN
admet-2214	718	21	for	for	ADP
admet-2214	718	22	enhanced	enhanced	ADJ
admet-2214	718	23	anticancer	anticancer	NOUN
admet-2214	718	24	drug	drug	NOUN
admet-2214	718	25	delivery	delivery	NOUN
admet-2214	718	26	to	to	PART
admet-2214	718	27	brain	brain	NOUN
admet-2214	718	28	cancer	cancer	NOUN
admet-2214	718	29	cells	cell	NOUN
admet-2214	718	30	:	:	PUNCT
admet-2214	718	31	an	an	DET
admet-2214	718	32	in	in	ADP
admet-2214	718	33	vitro	vitro	X
admet-2214	718	34	evaluation	evaluation	NOUN
admet-2214	718	35	.	.	PUNCT
admet-2214	719	1	indian	indian	ADJ
admet-2214	719	2	journal	journal	PROPN
admet-2214	719	3	of	of	ADP
admet-2214	719	4	medical	medical	ADJ
admet-2214	719	5	research	research	NOUN
admet-2214	719	6	159(1	159(1	NUM
admet-2214	719	7	)	)	PUNCT
admet-2214	719	8	(	(	PUNCT
admet-2214	719	9	2022	2022	NUM
admet-2214	719	10	)	)	PUNCT
admet-2214	719	11	139	139	NUM
admet-2214	719	12	-	-	SYM
admet-2214	719	13	148	148	NUM
admet-2214	719	14	.	.	PUNCT
admet-2214	719	15	https://doi.org/10.4103/ijmr.ijmr_514_19	https://doi.org/10.4103/ijmr.ijmr_514_19	X
admet-2214	720	1	[	[	X
admet-2214	720	2	85	85	NUM
admet-2214	720	3	]	]	PUNCT
admet-2214	720	4	i.	i.	NOUN
admet-2214	720	5	banerjee	banerjee	PROPN
admet-2214	720	6	,	,	PUNCT
admet-2214	720	7	k.	k.	PROPN
admet-2214	720	8	de	de	PROPN
admet-2214	720	9	,	,	PUNCT
admet-2214	720	10	d.	d.	PROPN
admet-2214	720	11	mukherjee	mukherjee	PROPN
admet-2214	720	12	,	,	PUNCT
admet-2214	720	13	g.	g.	PROPN
admet-2214	720	14	dey	dey	PROPN
admet-2214	720	15	,	,	PUNCT
admet-2214	720	16	s.	s.	PROPN
admet-2214	720	17	chattopadhyay	chattopadhyay	PROPN
admet-2214	720	18	,	,	PUNCT
admet-2214	720	19	m.	m.	NOUN
admet-2214	720	20	mukherjee	mukherjee	PROPN
admet-2214	720	21	,	,	PUNCT
admet-2214	720	22	m.	m.	NOUN
admet-2214	720	23	mandal	mandal	PROPN
admet-2214	720	24	,	,	PUNCT
admet-2214	720	25	a.k	a.k	PROPN
admet-2214	720	26	.	.	PROPN
admet-2214	720	27	bandyopadhyay	bandyopadhyay	PROPN
admet-2214	720	28	,	,	PUNCT
admet-2214	720	29	a.	a.	PROPN
admet-2214	720	30	gupta	gupta	PROPN
admet-2214	720	31	,	,	PUNCT
admet-2214	720	32	s.	s.	PROPN
admet-2214	720	33	ganguly	ganguly	PROPN
admet-2214	720	34	,	,	PUNCT
admet-2214	720	35	m.	m.	NOUN
admet-2214	720	36	misra	misra	NOUN
admet-2214	720	37	.	.	PUNCT
admet-2214	721	1	paclitaxel	paclitaxel	NOUN
admet-2214	721	2	-	-	PUNCT
admet-2214	721	3	loaded	load	VERB
admet-2214	721	4	solid	solid	ADJ
admet-2214	721	5	lipid	lipid	NOUN
admet-2214	721	6	nanoparticles	nanoparticle	NOUN
admet-2214	721	7	modified	modify	VERB
admet-2214	721	8	with	with	ADP
admet-2214	721	9	tyr-3	tyr-3	NOUN
admet-2214	721	10	-	-	ADJ
admet-2214	721	11	octreotide	octreotide	NOUN
admet-2214	721	12	for	for	ADP
admet-2214	721	13	enhanced	enhance	VERB
admet-2214	721	14	anti	anti	ADJ
admet-2214	721	15	-	-	ADJ
admet-2214	721	16	angiogenic	angiogenic	ADJ
admet-2214	721	17	and	and	CCONJ
admet-2214	721	18	anti	anti	ADJ
admet-2214	721	19	-	-	ADJ
admet-2214	721	20	glioma	glioma	ADJ
admet-2214	721	21	therapy	therapy	NOUN
admet-2214	721	22	.	.	PUNCT
admet-2214	722	1	acta	acta	PROPN
admet-2214	722	2	biomaterialia	biomaterialia	PROPN
admet-2214	722	3	38	38	NUM
admet-2214	722	4	(	(	PUNCT
admet-2214	722	5	2016	2016	NUM
admet-2214	722	6	)	)	PUNCT
admet-2214	722	7	69	69	NUM
admet-2214	722	8	-	-	SYM
admet-2214	722	9	81	81	NUM
admet-2214	722	10	.	.	PUNCT
admet-2214	723	1	https://doi.org/10.1016/j.actbio.2016.04.026	https://doi.org/10.1016/j.actbio.2016.04.026	PROPN
admet-2214	724	1	[	[	X
admet-2214	724	2	86	86	NUM
admet-2214	724	3	]	]	X
admet-2214	724	4	k.s	k.s	PROPN
admet-2214	724	5	.	.	PROPN
admet-2214	724	6	joshy	joshy	PROPN
admet-2214	724	7	,	,	PUNCT
admet-2214	724	8	c.p	c.p	PROPN
admet-2214	724	9	.	.	PROPN
admet-2214	724	10	sharma	sharma	PROPN
admet-2214	724	11	,	,	PUNCT
admet-2214	724	12	n.	n.	PROPN
admet-2214	724	13	kalarikkal	kalarikkal	PROPN
admet-2214	724	14	,	,	PUNCT
admet-2214	724	15	k.	k.	PROPN
admet-2214	724	16	sandeep	sandeep	PROPN
admet-2214	724	17	,	,	PUNCT
admet-2214	724	18	s.	s.	PROPN
admet-2214	724	19	thomas	thomas	PROPN
admet-2214	724	20	,	,	PUNCT
admet-2214	724	21	l.a	l.a	PROPN
admet-2214	724	22	.	.	PROPN
admet-2214	724	23	pothen	pothen	PROPN
admet-2214	724	24	.	.	PUNCT
admet-2214	725	1	evaluation	evaluation	NOUN
admet-2214	725	2	of	of	ADP
admet-2214	725	3	in	in	ADP
admet-2214	725	4	-	-	PUNCT
admet-2214	725	5	vitro	vitro	X
admet-2214	725	6	cytotoxicity	cytotoxicity	NOUN
admet-2214	725	7	and	and	CCONJ
admet-2214	725	8	cellular	cellular	ADJ
admet-2214	725	9	uptake	uptake	ADJ
admet-2214	725	10	efficiency	efficiency	NOUN
admet-2214	725	11	of	of	ADP
admet-2214	725	12	zidovudine	zidovudine	NOUN
admet-2214	725	13	-	-	PUNCT
admet-2214	725	14	loaded	load	VERB
admet-2214	725	15	solid	solid	ADJ
admet-2214	725	16	lipid	lipid	NOUN
admet-2214	725	17	nanoparticles	nanoparticle	NOUN
admet-2214	725	18	modified	modify	VERB
admet-2214	725	19	with	with	ADP
admet-2214	725	20	aloe	aloe	PROPN
admet-2214	725	21	vera	vera	NOUN
admet-2214	725	22	in	in	ADP
admet-2214	725	23	glioma	glioma	NOUN
admet-2214	725	24	cells	cell	NOUN
admet-2214	725	25	.	.	PUNCT
admet-2214	726	1	materials	material	NOUN
admet-2214	726	2	science	science	NOUN
admet-2214	726	3	and	and	CCONJ
admet-2214	726	4	engineering	engineering	NOUN
admet-2214	726	5	c	c	PROPN
admet-2214	726	6	66	66	NUM
admet-2214	726	7	(	(	PUNCT
admet-2214	726	8	2016	2016	NUM
admet-2214	726	9	)	)	PUNCT
admet-2214	726	10	40	40	NUM
admet-2214	726	11	-	-	SYM
admet-2214	726	12	50	50	NUM
admet-2214	726	13	.	.	PUNCT
admet-2214	727	1	https://doi.org/10.1016/j.msec.2016.03.031	https://doi.org/10.1016/j.msec.2016.03.031	NOUN
admet-2214	727	2	[	[	X
admet-2214	727	3	87	87	NUM
admet-2214	727	4	]	]	PUNCT
admet-2214	727	5	a.	a.	NOUN
admet-2214	727	6	grillone	grillone	NOUN
admet-2214	727	7	,	,	PUNCT
admet-2214	727	8	m.	m.	NOUN
admet-2214	727	9	battaglini	battaglini	PROPN
admet-2214	727	10	,	,	PUNCT
admet-2214	727	11	s.	s.	PROPN
admet-2214	727	12	moscato	moscato	PROPN
admet-2214	727	13	,	,	PUNCT
admet-2214	727	14	l.	l.	PROPN
admet-2214	727	15	mattii	mattii	PROPN
admet-2214	727	16	,	,	PUNCT
admet-2214	727	17	c.	c.	PROPN
admet-2214	727	18	de	de	PROPN
admet-2214	727	19	julián	julián	PROPN
admet-2214	727	20	fernández	fernández	PROPN
admet-2214	727	21	,	,	PUNCT
admet-2214	727	22	a.	a.	NOUN
admet-2214	727	23	scarpellini	scarpellini	PROPN
admet-2214	727	24	,	,	PUNCT
admet-2214	727	25	m.	m.	NOUN
admet-2214	727	26	giorgi	giorgi	PROPN
admet-2214	727	27	,	,	PUNCT
admet-2214	727	28	e.	e.	PROPN
admet-2214	727	29	sinibaldi	sinibaldi	PROPN
admet-2214	727	30	,	,	PUNCT
admet-2214	727	31	g.	g.	PROPN
admet-2214	727	32	ciofani	ciofani	PROPN
admet-2214	727	33	.	.	PUNCT
admet-2214	728	1	nutlin	nutlin	NOUN
admet-2214	728	2	-	-	PUNCT
admet-2214	728	3	loaded	load	VERB
admet-2214	728	4	magnetic	magnetic	ADJ
admet-2214	728	5	solid	solid	ADJ
admet-2214	728	6	lipid	lipid	NOUN
admet-2214	728	7	nanoparticles	nanoparticle	NOUN
admet-2214	728	8	for	for	ADP
admet-2214	728	9	targeted	target	VERB
admet-2214	728	10	glioblastoma	glioblastoma	NOUN
admet-2214	728	11	treatment	treatment	NOUN
admet-2214	728	12	.	.	PUNCT
admet-2214	729	1	nanomedicine	nanomedicine	NOUN
admet-2214	729	2	14	14	NUM
admet-2214	729	3	(	(	PUNCT
admet-2214	729	4	2019	2019	NUM
admet-2214	729	5	)	)	PUNCT
admet-2214	729	6	727	727	NUM
admet-2214	729	7	-	-	SYM
admet-2214	729	8	752	752	NUM
admet-2214	729	9	.	.	PUNCT
admet-2214	730	1	https://doi.org/10.2217/nnm-2018-0436	https://doi.org/10.2217/nnm-2018-0436	PROPN
admet-2214	731	1	[	[	X
admet-2214	731	2	88	88	NUM
admet-2214	731	3	]	]	PUNCT
admet-2214	731	4	m.	m.	NOUN
admet-2214	731	5	elmowafy	elmowafy	PROPN
admet-2214	731	6	,	,	PUNCT
admet-2214	731	7	m.m	m.m	PROPN
admet-2214	731	8	.	.	PROPN
admet-2214	731	9	al	al	PROPN
admet-2214	731	10	-	-	PUNCT
admet-2214	731	11	sanea	sanea	PROPN
admet-2214	731	12	.	.	PUNCT
admet-2214	732	1	nanostructured	nanostructure	VERB
admet-2214	732	2	lipid	lipid	NOUN
admet-2214	732	3	carriers	carrier	NOUN
admet-2214	732	4	(	(	PUNCT
admet-2214	732	5	nlcs	nlcs	PROPN
admet-2214	732	6	)	)	PUNCT
admet-2214	732	7	as	as	ADP
admet-2214	732	8	drug	drug	NOUN
admet-2214	732	9	delivery	delivery	NOUN
admet-2214	732	10	platform	platform	NOUN
admet-2214	732	11	:	:	PUNCT
admet-2214	732	12	advances	advance	NOUN
admet-2214	732	13	in	in	ADP
admet-2214	732	14	formulation	formulation	NOUN
admet-2214	732	15	and	and	CCONJ
admet-2214	732	16	delivery	delivery	NOUN
admet-2214	732	17	strategies	strategy	NOUN
admet-2214	732	18	.	.	PUNCT
admet-2214	733	1	saudi	saudi	ADJ
admet-2214	733	2	pharmaceutical	pharmaceutical	PROPN
admet-2214	733	3	journal	journal	PROPN
admet-2214	733	4	29	29	NUM
admet-2214	733	5	(	(	PUNCT
admet-2214	733	6	2021	2021	NUM
admet-2214	733	7	)	)	PUNCT
admet-2214	733	8	999	999	NUM
admet-2214	733	9	-	-	SYM
admet-2214	733	10	1012	1012	NUM
admet-2214	733	11	.	.	PUNCT
admet-2214	734	1	https://doi.org/10.1016/j.jsps.2021.07.015	https://doi.org/10.1016/j.jsps.2021.07.015	PUNCT
admet-2214	734	2	[	[	X
admet-2214	734	3	89	89	NUM
admet-2214	734	4	]	]	PUNCT
admet-2214	734	5	m.	m.	NOUN
admet-2214	734	6	aliofkhazraei	aliofkhazraei	NOUN
admet-2214	734	7	.	.	PUNCT
admet-2214	735	1	handbook	handbook	NOUN
admet-2214	735	2	of	of	ADP
admet-2214	735	3	nanoparticles	nanoparticle	NOUN
admet-2214	735	4	.	.	PUNCT
admet-2214	736	1	springer	springer	NOUN
admet-2214	736	2	international	international	PROPN
admet-2214	736	3	publishing	publishing	PROPN
admet-2214	736	4	switzerland	switzerland	PROPN
admet-2214	736	5	,	,	PUNCT
admet-2214	736	6	2016	2016	NUM
admet-2214	736	7	.	.	PUNCT
admet-2214	737	1	https://doi.org/10.1007/978-3-319-15338-4	https://doi.org/10.1007/978-3-319-15338-4	PROPN
admet-2214	737	2	[	[	X
admet-2214	737	3	90	90	NUM
admet-2214	737	4	]	]	PUNCT
admet-2214	737	5	a.	a.	NOUN
admet-2214	737	6	khosa	khosa	PROPN
admet-2214	737	7	,	,	PUNCT
admet-2214	737	8	s.	s.	PROPN
admet-2214	737	9	reddi	reddi	PROPN
admet-2214	737	10	,	,	PUNCT
admet-2214	737	11	r.n	r.n	PROPN
admet-2214	737	12	.	.	PROPN
admet-2214	737	13	saha	saha	PROPN
admet-2214	737	14	.	.	PUNCT
admet-2214	738	1	nanostructured	nanostructure	VERB
admet-2214	738	2	lipid	lipid	NOUN
admet-2214	738	3	carriers	carrier	NOUN
admet-2214	738	4	for	for	ADP
admet-2214	738	5	site	site	NOUN
admet-2214	738	6	-	-	PUNCT
admet-2214	738	7	specific	specific	ADJ
admet-2214	738	8	drug	drug	NOUN
admet-2214	738	9	delivery	delivery	NOUN
admet-2214	738	10	.	.	PUNCT
admet-2214	739	1	biomedicine	biomedicine	NOUN
admet-2214	739	2	and	and	CCONJ
admet-2214	739	3	pharmacotherapy	pharmacotherapy	NOUN
admet-2214	739	4	103	103	NUM
admet-2214	739	5	(	(	PUNCT
admet-2214	739	6	2018	2018	NUM
admet-2214	739	7	)	)	PUNCT
admet-2214	739	8	598	598	NUM
admet-2214	739	9	-	-	SYM
admet-2214	739	10	613	613	NUM
admet-2214	739	11	.	.	PUNCT
admet-2214	740	1	https://doi.org/10.1016/j.biopha.2018.04.055	https://doi.org/10.1016/j.biopha.2018.04.055	PROPN
admet-2214	740	2	[	[	X
admet-2214	740	3	91	91	NUM
admet-2214	740	4	]	]	PUNCT
admet-2214	740	5	j.	j.	PROPN
admet-2214	740	6	qu	qu	PROPN
admet-2214	740	7	,	,	PUNCT
admet-2214	740	8	l.	l.	PROPN
admet-2214	740	9	zhang	zhang	PROPN
admet-2214	740	10	,	,	PUNCT
admet-2214	740	11	z.	z.	PROPN
admet-2214	740	12	chen	chen	PROPN
admet-2214	740	13	,	,	PUNCT
admet-2214	740	14	g.	g.	PROPN
admet-2214	740	15	mao	mao	PROPN
admet-2214	740	16	,	,	PUNCT
admet-2214	740	17	z.	z.	PROPN
admet-2214	740	18	gao	gao	PROPN
admet-2214	740	19	,	,	PUNCT
admet-2214	740	20	x.	x.	PROPN
admet-2214	740	21	lai	lai	PROPN
admet-2214	740	22	,	,	PUNCT
admet-2214	740	23	x.	x.	PROPN
admet-2214	740	24	zhu	zhu	PROPN
admet-2214	740	25	,	,	PUNCT
admet-2214	740	26	j.	j.	PROPN
admet-2214	740	27	zhu	zhu	PROPN
admet-2214	740	28	.	.	PUNCT
admet-2214	741	1	nanostructured	nanostructure	VERB
admet-2214	741	2	lipid	lipid	NOUN
admet-2214	741	3	carriers	carrier	NOUN
admet-2214	741	4	,	,	PUNCT
admet-2214	741	5	solid	solid	ADJ
admet-2214	741	6	lipid	lipid	NOUN
admet-2214	741	7	nanoparticles	nanoparticle	NOUN
admet-2214	741	8	,	,	PUNCT
admet-2214	741	9	and	and	CCONJ
admet-2214	741	10	polymeric	polymeric	ADJ
admet-2214	741	11	nanoparticles	nanoparticle	NOUN
admet-2214	741	12	:	:	PUNCT
admet-2214	741	13	which	which	DET
admet-2214	741	14	kind	kind	NOUN
admet-2214	741	15	of	of	ADP
admet-2214	741	16	drug	drug	NOUN
admet-2214	741	17	delivery	delivery	NOUN
admet-2214	741	18	system	system	NOUN
admet-2214	741	19	is	be	AUX
admet-2214	741	20	better	well	ADJ
admet-2214	741	21	for	for	ADP
admet-2214	741	22	glioblastoma	glioblastoma	NOUN
admet-2214	741	23	chemotherapy	chemotherapy	NOUN
admet-2214	741	24	?	?	PUNCT
admet-2214	742	1	drug	drug	NOUN
admet-2214	742	2	delivery	delivery	NOUN
admet-2214	742	3	23	23	NUM
admet-2214	742	4	(	(	PUNCT
admet-2214	742	5	2016	2016	NUM
admet-2214	742	6	)	)	PUNCT
admet-2214	742	7	3408	3408	NUM
admet-2214	742	8	-	-	SYM
admet-2214	742	9	3416	3416	NUM
admet-2214	742	10	.	.	PUNCT
admet-2214	743	1	https://doi.org/10.1080/10717544.2016.1189465	https://doi.org/10.1080/10717544.2016.1189465	X
admet-2214	744	1	[	[	X
admet-2214	744	2	92	92	NUM
admet-2214	744	3	]	]	X
admet-2214	744	4	s.b	s.b	PROPN
admet-2214	744	5	.	.	PROPN
admet-2214	744	6	6	6	NUM
admet-2214	744	7	saurabh	saurabh	PROPN
admet-2214	744	8	mittal	mittal	PROPN
admet-2214	744	9	1	1	NUM
admet-2214	744	10	,	,	PUNCT
admet-2214	744	11	sadia	sadia	PROPN
admet-2214	744	12	shah	shah	PROPN
admet-2214	744	13	2	2	NUM
admet-2214	744	14	,	,	PUNCT
admet-2214	744	15	harlokesh	harlokesh	PROPN
admet-2214	744	16	narayan	narayan	PROPN
admet-2214	744	17	yadav	yadav	PROPN
admet-2214	744	18	3	3	NUM
admet-2214	744	19	,	,	PUNCT
admet-2214	744	20	javed	javed	PROPN
admet-2214	744	21	ali	ali	PROPN
admet-2214	744	22	4	4	PROPN
admet-2214	744	23	,	,	PUNCT
admet-2214	744	24	madan	madan	PROPN
admet-2214	744	25	mohan	mohan	PROPN
admet-2214	744	26	gupta	gupta	PROPN
admet-2214	744	27	5	5	NUM
admet-2214	744	28	.	.	PUNCT
admet-2214	744	29	quality	quality	NOUN
admet-2214	744	30	by	by	ADP
admet-2214	744	31	design	design	NOUN
admet-2214	744	32	engineered	engineer	VERB
admet-2214	744	33	,	,	PUNCT
admet-2214	744	34	enhanced	enhanced	ADJ
admet-2214	744	35	anticancer	anticancer	NOUN
admet-2214	744	36	activity	activity	NOUN
admet-2214	744	37	of	of	ADP
admet-2214	744	38	temozolomide	temozolomide	NOUN
admet-2214	744	39	and	and	CCONJ
admet-2214	744	40	resveratrol	resveratrol	NOUN
admet-2214	744	41	coloaded	coloade	VERB
admet-2214	744	42	nlc	nlc	PROPN
admet-2214	744	43	and	and	CCONJ
admet-2214	744	44	brain	brain	NOUN
admet-2214	744	45	targeting	target	VERB
admet-2214	744	46	via	via	ADP
admet-2214	744	47	lactoferrin	lactoferrin	ADJ
admet-2214	744	48	conjugation	conjugation	NOUN
admet-2214	744	49	in	in	ADP
admet-2214	744	50	treatment	treatment	NOUN
admet-2214	744	51	of	of	ADP
admet-2214	744	52	glioblastoma	glioblastoma	NOUN
admet-2214	744	53	.	.	PUNCT
admet-2214	745	1	european	european	PROPN
admet-2214	745	2	journal	journal	PROPN
admet-2214	745	3	of	of	ADP
admet-2214	745	4	pharmaceutics	pharmaceutic	NOUN
admet-2214	745	5	and	and	CCONJ
admet-2214	745	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2214	745	7	191	191	NUM
admet-2214	745	8	(	(	PUNCT
admet-2214	745	9	2023	2023	NUM
admet-2214	745	10	)	)	PUNCT
admet-2214	745	11	175	175	NUM
admet-2214	745	12	-	-	SYM
admet-2214	745	13	188	188	NUM
admet-2214	745	14	.	.	PUNCT
admet-2214	746	1	https://doi.org/10.1016/j.ejpb.2023.08.018	https://doi.org/10.1016/j.ejpb.2023.08.018	NOUN
admet-2214	747	1	[	[	X
admet-2214	747	2	93	93	X
admet-2214	747	3	]	]	PUNCT
admet-2214	747	4	t.	t.	NOUN
admet-2214	747	5	zwain	zwain	PROPN
admet-2214	747	6	,	,	PUNCT
admet-2214	747	7	j.e	j.e	PROPN
admet-2214	747	8	.	.	PROPN
admet-2214	747	9	alder	alder	PROPN
admet-2214	747	10	,	,	PUNCT
admet-2214	747	11	b.	b.	PROPN
admet-2214	747	12	sabagh	sabagh	PROPN
admet-2214	747	13	,	,	PUNCT
admet-2214	747	14	a.	a.	PROPN
admet-2214	747	15	shaw	shaw	PROPN
admet-2214	747	16	,	,	PUNCT
admet-2214	747	17	a.j	a.j	PROPN
admet-2214	747	18	.	.	PROPN
admet-2214	747	19	burrow	burrow	PROPN
admet-2214	747	20	,	,	PUNCT
admet-2214	747	21	k.k	k.k	PROPN
admet-2214	747	22	.	.	PROPN
admet-2214	747	23	singh	singh	PROPN
admet-2214	747	24	.	.	PUNCT
admet-2214	748	1	tailoring	tailor	VERB
admet-2214	748	2	functional	functional	ADJ
admet-2214	748	3	nanostructured	nanostructure	VERB
admet-2214	748	4	lipid	lipid	NOUN
admet-2214	748	5	carriers	carrier	NOUN
admet-2214	748	6	for	for	ADP
admet-2214	748	7	glioblastoma	glioblastoma	NOUN
admet-2214	748	8	treatment	treatment	NOUN
admet-2214	748	9	with	with	ADP
admet-2214	748	10	enhanced	enhanced	ADJ
admet-2214	748	11	permeability	permeability	NOUN
admet-2214	748	12	through	through	ADP
admet-2214	748	13	in	in	ADP
admet-2214	748	14	-	-	PUNCT
admet-2214	748	15	vitro	vitro	X
admet-2214	748	16	3d	3d	PROPN
admet-2214	748	17	bbb	bbb	PROPN
admet-2214	748	18	/	/	SYM
admet-2214	748	19	bbtb	bbtb	NOUN
admet-2214	748	20	models	model	NOUN
admet-2214	748	21	.	.	PUNCT
admet-2214	749	1	materials	material	NOUN
admet-2214	749	2	science	science	NOUN
admet-2214	749	3	and	and	CCONJ
admet-2214	749	4	engineering	engineering	NOUN
admet-2214	749	5	:	:	PUNCT
admet-2214	749	6	c	c	NOUN
admet-2214	749	7	121	121	NUM
admet-2214	749	8	(	(	PUNCT
admet-2214	749	9	2021	2021	NUM
admet-2214	749	10	)	)	PUNCT
admet-2214	749	11	111774	111774	NUM
admet-2214	749	12	.	.	PUNCT
admet-2214	750	1	https://doi.org/10.1016/j.msec.2020.111774	https://doi.org/10.1016/j.msec.2020.111774	PROPN
admet-2214	750	2	[	[	X
admet-2214	750	3	94	94	X
admet-2214	750	4	]	]	X
admet-2214	750	5	h.v	h.v	PROPN
admet-2214	750	6	.	.	PROPN
admet-2214	750	7	b	b	PROPN
admet-2214	751	1	d	d	PROPN
admet-2214	751	2	masoud	masoud	PROPN
admet-2214	751	3	farshbaf	farshbaf	PROPN
admet-2214	751	4	a	a	DET
admet-2214	751	5	b	b	PROPN
admet-2214	751	6	c	c	X
admet-2214	751	7	,	,	PUNCT
admet-2214	751	8	solmaz	solmaz	PROPN
admet-2214	751	9	mojarad	mojarad	PROPN
admet-2214	751	10	-	-	PROPN
admet-2214	751	11	jabali	jabali	PROPN
admet-2214	751	12	b	b	PROPN
admet-2214	751	13	d	d	PROPN
admet-2214	751	14	,	,	PUNCT
admet-2214	751	15	salar	salar	NOUN
admet-2214	751	16	hemmati	hemmati	PROPN
admet-2214	751	17	b	b	PROPN
admet-2214	751	18	,	,	PUNCT
admet-2214	751	19	ahmad	ahmad	PROPN
admet-2214	751	20	yari	yari	PROPN
admet-2214	751	21	khosroushahi	khosroushahi	VERB
admet-2214	751	22	a	a	DET
admet-2214	751	23	b	b	NOUN
admet-2214	751	24	,	,	PUNCT
admet-2214	751	25	hamidreza	hamidreza	PROPN
admet-2214	751	26	motasadizadeh	motasadizadeh	NOUN
admet-2214	752	1	e	e	PROPN
admet-2214	752	2	f	f	PROPN
admet-2214	752	3	,	,	PUNCT
admet-2214	752	4	amir	amir	PROPN
admet-2214	752	5	zarebkohan	zarebkohan	PROPN
admet-2214	752	6	a.	a.	PROPN
admet-2214	752	7	enhanced	enhance	VERB
admet-2214	752	8	bbb	bbb	PROPN
admet-2214	752	9	and	and	CCONJ
admet-2214	752	10	bbtb	bbtb	NOUN
admet-2214	752	11	penetration	penetration	NOUN
admet-2214	752	12	and	and	CCONJ
admet-2214	752	13	improved	improve	VERB
admet-2214	752	14	anti	anti	ADJ
admet-2214	752	15	-	-	ADJ
admet-2214	752	16	glioma	glioma	ADJ
admet-2214	752	17	behavior	behavior	NOUN
admet-2214	752	18	of	of	ADP
admet-2214	752	19	bortezomib	bortezomib	NOUN
admet-2214	752	20	through	through	ADP
admet-2214	752	21	dual	dual	ADV
admet-2214	752	22	-	-	PUNCT
admet-2214	752	23	targeting	target	VERB
admet-2214	752	24	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	ADJ
admet-2214	752	25	https://doi.org/10.4103/0250-474x.57282	https://doi.org/10.4103/0250-474x.57282	PROPN
admet-2214	752	26	https://doi.org/10.1016/j.colsurfb.2021.111946	https://doi.org/10.1016/j.colsurfb.2021.111946	PROPN
admet-2214	752	27	https://doi.org/10.4136/ambi-agua.2483	https://doi.org/10.4136/ambi-agua.2483	NOUN
admet-2214	752	28	https://doi.org/10.1016/j.ijpharm.2012.03.027	https://doi.org/10.1016/j.ijpharm.2012.03.027	PROPN
admet-2214	752	29	https://doi.org/10.4103/ijmr.ijmr_514_19	https://doi.org/10.4103/ijmr.ijmr_514_19	PROPN
admet-2214	752	30	https://doi.org/10.1016/j.actbio.2016.04.026	https://doi.org/10.1016/j.actbio.2016.04.026	PROPN
admet-2214	752	31	https://doi.org/10.1016/j.msec.2016.03.031	https://doi.org/10.1016/j.msec.2016.03.031	NOUN
admet-2214	752	32	https://doi.org/10.2217/nnm-2018-0436	https://doi.org/10.2217/nnm-2018-0436	NOUN
admet-2214	752	33	https://doi.org/10.1016/j.jsps.2021.07.015	https://doi.org/10.1016/j.jsps.2021.07.015	PROPN
admet-2214	752	34	https://doi.org/10.1007/978-3-319-15338-4	https://doi.org/10.1007/978-3-319-15338-4	PROPN
admet-2214	752	35	https://doi.org/10.1016/j.biopha.2018.04.055	https://doi.org/10.1016/j.biopha.2018.04.055	NOUN
admet-2214	752	36	https://doi.org/10.1080/10717544.2016.1189465	https://doi.org/10.1080/10717544.2016.1189465	PRON
admet-2214	752	37	https://doi.org/10.1016/j.ejpb.2023.08.018	https://doi.org/10.1016/j.ejpb.2023.08.018	NOUN
admet-2214	752	38	https://doi.org/10.1016/j.msec.2020.111774	https://doi.org/10.1016/j.msec.2020.111774	PROPN
admet-2214	752	39	z.	z.	PROPN
admet-2214	752	40	presswala	presswala	PROPN
admet-2214	753	1	et	et	PROPN
admet-2214	753	2	al	al	PROPN
admet-2214	753	3	.	.	PROPN
admet-2214	753	4	admet	admet	PROPN
admet-2214	753	5	&	&	CCONJ
admet-2214	753	6	dmpk	dmpk	PROPN
admet-2214	753	7	12(3	12(3	PROPN
admet-2214	753	8	)	)	PUNCT
admet-2214	753	9	(	(	PUNCT
admet-2214	753	10	2024	2024	NUM
admet-2214	753	11	)	)	PUNCT
admet-2214	753	12	403	403	NUM
admet-2214	753	13	-	-	SYM
admet-2214	753	14	429	429	NUM
admet-2214	753	15	428	428	NUM
admet-2214	753	16	nanostructured	nanostructure	VERB
admet-2214	753	17	lipid	lipid	NOUN
admet-2214	753	18	carriers	carrier	NOUN
admet-2214	753	19	.	.	PUNCT
admet-2214	754	1	journal	journal	PROPN
admet-2214	754	2	of	of	ADP
admet-2214	754	3	controlled	control	VERB
admet-2214	754	4	release	release	NOUN
admet-2214	754	5	345	345	NUM
admet-2214	754	6	(	(	PUNCT
admet-2214	754	7	2022	2022	NUM
admet-2214	754	8	)	)	PUNCT
admet-2214	754	9	371	371	NUM
admet-2214	754	10	-	-	SYM
admet-2214	754	11	384	384	NUM
admet-2214	754	12	.	.	PUNCT
admet-2214	755	1	https://doi.org/10.1016/j.jconrel.2022.03.019	https://doi.org/10.1016/j.jconrel.2022.03.019	NUM
admet-2214	755	2	[	[	X
admet-2214	755	3	95	95	NUM
admet-2214	755	4	]	]	X
admet-2214	755	5	a.s	a.s	PROPN
admet-2214	755	6	.	.	PROPN
admet-2214	755	7	shirazi	shirazi	PROPN
admet-2214	755	8	,	,	PUNCT
admet-2214	755	9	r.	r.	PROPN
admet-2214	755	10	varshochian	varshochian	PROPN
admet-2214	755	11	,	,	PUNCT
admet-2214	755	12	m.	m.	NOUN
admet-2214	755	13	rezaei	rezaei	PROPN
admet-2214	755	14	,	,	PUNCT
admet-2214	755	15	y.h	y.h	PROPN
admet-2214	755	16	.	.	PROPN
admet-2214	755	17	ardakani	ardakani	PROPN
admet-2214	755	18	,	,	PUNCT
admet-2214	755	19	r.	r.	PROPN
admet-2214	755	20	dinarvand	dinarvand	PROPN
admet-2214	755	21	.	.	PUNCT
admet-2214	756	1	sn38	sn38	PROPN
admet-2214	756	2	loaded	load	VERB
admet-2214	756	3	nanostructured	nanostructure	VERB
admet-2214	756	4	lipid	lipid	NOUN
admet-2214	756	5	carriers	carrier	NOUN
admet-2214	756	6	(	(	PUNCT
admet-2214	756	7	nlcs	nlcs	PROPN
admet-2214	756	8	)	)	PUNCT
admet-2214	756	9	;	;	PUNCT
admet-2214	756	10	preparation	preparation	NOUN
admet-2214	756	11	and	and	CCONJ
admet-2214	756	12	in	in	ADP
admet-2214	756	13	vitro	vitro	X
admet-2214	756	14	evaluations	evaluation	NOUN
admet-2214	756	15	against	against	ADP
admet-2214	756	16	glioblastoma	glioblastoma	NOUN
admet-2214	756	17	.	.	PUNCT
admet-2214	757	1	journal	journal	PROPN
admet-2214	757	2	of	of	ADP
admet-2214	757	3	materials	material	NOUN
admet-2214	757	4	science	science	NOUN
admet-2214	757	5	:	:	PUNCT
admet-2214	757	6	materials	material	NOUN
admet-2214	757	7	in	in	ADP
admet-2214	757	8	medicine	medicine	NOUN
admet-2214	757	9	32	32	NUM
admet-2214	757	10	(	(	PUNCT
admet-2214	757	11	2021	2021	NUM
admet-2214	757	12	)	)	PUNCT
admet-2214	757	13	78	78	NUM
admet-2214	757	14	.	.	PUNCT
admet-2214	758	1	https://doi.org/10.1007/s10856-021-06538-2	https://doi.org/10.1007/s10856-021-06538-2	NUM
admet-2214	759	1	[	[	X
admet-2214	759	2	96	96	NUM
admet-2214	759	3	]	]	PUNCT
admet-2214	759	4	s.	s.	PROPN
admet-2214	759	5	zhang	zhang	PROPN
admet-2214	759	6	,	,	PUNCT
admet-2214	759	7	c.	c.	PROPN
admet-2214	759	8	lu	lu	PROPN
admet-2214	759	9	,	,	PUNCT
admet-2214	759	10	x.	x.	PROPN
admet-2214	759	11	zhang	zhang	PROPN
admet-2214	759	12	,	,	PUNCT
admet-2214	759	13	j.	j.	PROPN
admet-2214	759	14	li	li	PROPN
admet-2214	759	15	,	,	PUNCT
admet-2214	759	16	h.	h.	PROPN
admet-2214	759	17	jiang	jiang	PROPN
admet-2214	759	18	.	.	PUNCT
admet-2214	760	1	targeted	target	VERB
admet-2214	760	2	delivery	delivery	NOUN
admet-2214	760	3	of	of	ADP
admet-2214	760	4	etoposide	etoposide	NOUN
admet-2214	760	5	to	to	ADP
admet-2214	760	6	cancer	cancer	NOUN
admet-2214	760	7	cells	cell	NOUN
admet-2214	760	8	by	by	ADP
admet-2214	760	9	folatemodified	folatemodifie	VERB
admet-2214	760	10	nanostructured	nanostructure	VERB
admet-2214	760	11	lipid	lipid	NOUN
admet-2214	760	12	drug	drug	NOUN
admet-2214	760	13	delivery	delivery	NOUN
admet-2214	760	14	system	system	NOUN
admet-2214	760	15	.	.	PUNCT
admet-2214	761	1	drug	drug	NOUN
admet-2214	761	2	delivery	delivery	NOUN
admet-2214	761	3	23	23	NUM
admet-2214	761	4	(	(	PUNCT
admet-2214	761	5	2016	2016	NUM
admet-2214	761	6	)	)	PUNCT
admet-2214	761	7	1838	1838	NUM
admet-2214	761	8	-	-	SYM
admet-2214	761	9	1845	1845	NUM
admet-2214	761	10	.	.	PUNCT
admet-2214	762	1	https://doi.org/10.3109/10717544.2016.1141258	https://doi.org/10.3109/10717544.2016.1141258	PUNCT
admet-2214	763	1	[	[	X
admet-2214	763	2	97	97	NUM
admet-2214	763	3	]	]	X
admet-2214	763	4	d.c.f	d.c.f	PROPN
admet-2214	763	5	.	.	PUNCT
admet-2214	763	6	soares	soares	PROPN
admet-2214	763	7	,	,	PUNCT
admet-2214	763	8	f.	f.	PROPN
admet-2214	763	9	poletto	poletto	PROPN
admet-2214	763	10	,	,	PUNCT
admet-2214	763	11	m.j	m.j	PROPN
admet-2214	763	12	.	.	PROPN
admet-2214	763	13	eberhardt	eberhardt	PROPN
admet-2214	763	14	,	,	PUNCT
admet-2214	763	15	s.c	s.c	PROPN
admet-2214	763	16	.	.	PROPN
admet-2214	763	17	domingues	domingues	PROPN
admet-2214	763	18	,	,	PUNCT
admet-2214	763	19	f.b	f.b	PROPN
admet-2214	763	20	.	.	PROPN
admet-2214	763	21	de	de	PROPN
admet-2214	763	22	sousa	sousa	PROPN
admet-2214	763	23	,	,	PUNCT
admet-2214	763	24	m.l	m.l	PROPN
admet-2214	763	25	.	.	PROPN
admet-2214	763	26	tebaldi	tebaldi	PROPN
admet-2214	763	27	.	.	PUNCT
admet-2214	764	1	polymerhybrid	polymerhybrid	NOUN
admet-2214	764	2	nanosystems	nanosystem	NOUN
admet-2214	764	3	for	for	ADP
admet-2214	764	4	antiviral	antiviral	ADJ
admet-2214	764	5	applications	application	NOUN
admet-2214	764	6	:	:	PUNCT
admet-2214	764	7	current	current	ADJ
admet-2214	764	8	advances	advance	NOUN
admet-2214	764	9	.	.	PUNCT
admet-2214	765	1	biomedicine	biomedicine	NOUN
admet-2214	765	2	and	and	CCONJ
admet-2214	765	3	pharmacotherapy	pharmacotherapy	NOUN
admet-2214	765	4	146	146	NUM
admet-2214	765	5	(	(	PUNCT
admet-2214	765	6	2022	2022	NUM
admet-2214	765	7	)	)	PUNCT
admet-2214	765	8	112249	112249	NUM
admet-2214	765	9	.	.	PUNCT
admet-2214	766	1	https://doi.org/10.1016/j.biopha.2021.112249	https://doi.org/10.1016/j.biopha.2021.112249	PROPN
admet-2214	766	2	[	[	X
admet-2214	766	3	98	98	NUM
admet-2214	766	4	]	]	PUNCT
admet-2214	766	5	a.	a.	NOUN
admet-2214	766	6	mukherjee	mukherjee	PROPN
admet-2214	766	7	,	,	PUNCT
admet-2214	766	8	a.k	a.k	PROPN
admet-2214	766	9	.	.	PROPN
admet-2214	766	10	waters	water	NOUN
admet-2214	766	11	,	,	PUNCT
admet-2214	766	12	p.	p.	PROPN
admet-2214	766	13	kalyan	kalyan	PROPN
admet-2214	766	14	,	,	PUNCT
admet-2214	766	15	a.s	a.s	PROPN
admet-2214	766	16	.	.	PROPN
admet-2214	766	17	achrol	achrol	PROPN
admet-2214	766	18	,	,	PUNCT
admet-2214	766	19	s.	s.	PROPN
admet-2214	766	20	kesari	kesari	PROPN
admet-2214	766	21	,	,	PUNCT
admet-2214	766	22	v.m	v.m	PROPN
admet-2214	766	23	.	.	PROPN
admet-2214	766	24	yenugonda	yenugonda	NOUN
admet-2214	766	25	.	.	PUNCT
admet-2214	767	1	lipid	lipid	NOUN
admet-2214	767	2	-	-	PUNCT
admet-2214	767	3	polymer	polymer	NOUN
admet-2214	767	4	hybrid	hybrid	NOUN
admet-2214	767	5	nanoparticles	nanoparticle	NOUN
admet-2214	767	6	as	as	ADP
admet-2214	767	7	a	a	DET
admet-2214	767	8	nextgeneration	nextgeneration	NOUN
admet-2214	767	9	drug	drug	NOUN
admet-2214	767	10	delivery	delivery	NOUN
admet-2214	767	11	platform	platform	NOUN
admet-2214	767	12	:	:	PUNCT
admet-2214	767	13	state	state	NOUN
admet-2214	767	14	of	of	ADP
admet-2214	767	15	the	the	DET
admet-2214	767	16	art	art	NOUN
admet-2214	767	17	,	,	PUNCT
admet-2214	767	18	emerging	emerge	VERB
admet-2214	767	19	technologies	technology	NOUN
admet-2214	767	20	,	,	PUNCT
admet-2214	767	21	and	and	CCONJ
admet-2214	767	22	perspectives	perspective	NOUN
admet-2214	767	23	.	.	PUNCT
admet-2214	768	1	international	international	ADJ
admet-2214	768	2	journal	journal	NOUN
admet-2214	768	3	of	of	ADP
admet-2214	768	4	nanomedicine	nanomedicine	NOUN
admet-2214	768	5	14	14	NUM
admet-2214	768	6	(	(	PUNCT
admet-2214	768	7	2019	2019	NUM
admet-2214	768	8	)	)	PUNCT
admet-2214	768	9	1937	1937	NUM
admet-2214	768	10	-	-	SYM
admet-2214	768	11	1952	1952	NUM
admet-2214	768	12	https://doi.org/10.2147/ijn.s198353	https://doi.org/10.2147/ijn.s198353	PUNCT
admet-2214	769	1	[	[	X
admet-2214	769	2	99	99	NUM
admet-2214	769	3	]	]	PUNCT
admet-2214	769	4	k.	k.	PROPN
admet-2214	769	5	hadinoto	hadinoto	PROPN
admet-2214	769	6	,	,	PUNCT
admet-2214	769	7	a.	a.	PROPN
admet-2214	769	8	sundaresan	sundaresan	PROPN
admet-2214	769	9	,	,	PUNCT
admet-2214	769	10	w.s	w.s	PROPN
admet-2214	769	11	.	.	PUNCT
admet-2214	769	12	cheow	cheow	PROPN
admet-2214	769	13	.	.	PUNCT
admet-2214	770	1	lipid	lipid	NOUN
admet-2214	770	2	-	-	PUNCT
admet-2214	770	3	polymer	polymer	NOUN
admet-2214	770	4	hybrid	hybrid	NOUN
admet-2214	770	5	nanoparticles	nanoparticle	NOUN
admet-2214	770	6	as	as	ADP
admet-2214	770	7	a	a	DET
admet-2214	770	8	new	new	ADJ
admet-2214	770	9	generation	generation	NOUN
admet-2214	770	10	therapeutic	therapeutic	ADJ
admet-2214	770	11	delivery	delivery	NOUN
admet-2214	770	12	platform	platform	NOUN
admet-2214	770	13	:	:	PUNCT
admet-2214	770	14	a	a	DET
admet-2214	770	15	review	review	NOUN
admet-2214	770	16	.	.	PUNCT
admet-2214	771	1	european	european	PROPN
admet-2214	771	2	journal	journal	PROPN
admet-2214	771	3	of	of	ADP
admet-2214	771	4	pharmaceutics	pharmaceutic	NOUN
admet-2214	771	5	and	and	CCONJ
admet-2214	771	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2214	771	7	85	85	NUM
admet-2214	771	8	(	(	PUNCT
admet-2214	771	9	2013	2013	NUM
admet-2214	771	10	)	)	PUNCT
admet-2214	771	11	427	427	NUM
admet-2214	771	12	-	-	SYM
admet-2214	771	13	443	443	NUM
admet-2214	771	14	.	.	PUNCT
admet-2214	772	1	https://doi.org/10.1016/j.ejpb.2013.07.002	https://doi.org/10.1016/j.ejpb.2013.07.002	NOUN
admet-2214	772	2	[	[	X
admet-2214	772	3	100	100	NUM
admet-2214	772	4	]	]	PUNCT
admet-2214	772	5	v.	v.	PROPN
admet-2214	772	6	dave	dave	PROPN
admet-2214	772	7	,	,	PUNCT
admet-2214	772	8	k.	k.	PROPN
admet-2214	772	9	tak	tak	PROPN
admet-2214	772	10	,	,	PUNCT
admet-2214	772	11	a.	a.	NOUN
admet-2214	772	12	sohgaura	sohgaura	NOUN
admet-2214	772	13	,	,	PUNCT
admet-2214	772	14	a.	a.	PROPN
admet-2214	772	15	gupta	gupta	PROPN
admet-2214	772	16	,	,	PUNCT
admet-2214	772	17	v.	v.	X
admet-2214	772	18	sadhu	sadhu	PROPN
admet-2214	772	19	,	,	PUNCT
admet-2214	772	20	k.r	k.r	PROPN
admet-2214	772	21	.	.	PROPN
admet-2214	772	22	reddy	reddy	PROPN
admet-2214	772	23	.	.	PUNCT
admet-2214	773	1	lipid	lipid	NOUN
admet-2214	773	2	-	-	PUNCT
admet-2214	773	3	polymer	polymer	NOUN
admet-2214	773	4	hybrid	hybrid	ADJ
admet-2214	773	5	nanoparticles	nanoparticle	NOUN
admet-2214	773	6	:	:	PUNCT
admet-2214	773	7	synthesis	synthesis	NOUN
admet-2214	773	8	strategies	strategy	NOUN
admet-2214	773	9	and	and	CCONJ
admet-2214	773	10	biomedical	biomedical	ADJ
admet-2214	773	11	applications	application	NOUN
admet-2214	773	12	.	.	PUNCT
admet-2214	774	1	journal	journal	NOUN
admet-2214	774	2	of	of	ADP
admet-2214	774	3	microbiological	microbiological	ADJ
admet-2214	774	4	methods	method	NOUN
admet-2214	774	5	160	160	NUM
admet-2214	774	6	(	(	PUNCT
admet-2214	774	7	2019	2019	NUM
admet-2214	774	8	)	)	PUNCT
admet-2214	774	9	130	130	NUM
admet-2214	774	10	-	-	SYM
admet-2214	774	11	142	142	NUM
admet-2214	774	12	.	.	PUNCT
admet-2214	775	1	https://doi.org/10.1016/j.mimet.2019.03.017	https://doi.org/10.1016/j.mimet.2019.03.017	NOUN
admet-2214	775	2	[	[	X
admet-2214	775	3	101	101	NUM
admet-2214	775	4	]	]	X
admet-2214	775	5	h.x	h.x	PROPN
admet-2214	775	6	.	.	PROPN
admet-2214	775	7	5	5	NUM
admet-2214	775	8	xiaoqi	xiaoqi	PROPN
admet-2214	775	9	wang	wang	PROPN
admet-2214	775	10	,	,	PUNCT
admet-2214	775	11	lu	lu	PROPN
admet-2214	775	12	ye	ye	INTJ
admet-2214	775	13	,	,	PUNCT
admet-2214	775	14	weichong	weichong	NOUN
admet-2214	776	1	he	he	PRON
admet-2214	776	2	,	,	PUNCT
admet-2214	776	3	chuanhui	chuanhui	PROPN
admet-2214	776	4	teng	teng	PROPN
admet-2214	776	5	,	,	PUNCT
admet-2214	776	6	shanbo	shanbo	PROPN
admet-2214	776	7	sun	sun	PROPN
admet-2214	776	8	,	,	PUNCT
admet-2214	776	9	hongdan	hongdan	NOUN
admet-2214	776	10	lu	lu	PROPN
admet-2214	776	11	,	,	PUNCT
admet-2214	776	12	shengnan	shengnan	PROPN
admet-2214	776	13	li	li	PROPN
admet-2214	776	14	,	,	PUNCT
admet-2214	776	15	lingyan	lingyan	PROPN
admet-2214	776	16	lv	lv	PROPN
admet-2214	776	17	,	,	PUNCT
admet-2214	776	18	xiang	xiang	PROPN
admet-2214	776	19	cao	cao	PROPN
admet-2214	776	20	,	,	PUNCT
admet-2214	776	21	haoyuan	haoyuan	PROPN
admet-2214	776	22	yin	yin	PROPN
admet-2214	776	23	,	,	PUNCT
admet-2214	776	24	wei	wei	PROPN
admet-2214	776	25	lv	lv	PROPN
admet-2214	776	26	.	.	PUNCT
admet-2214	777	1	in	in	ADP
admet-2214	777	2	situ	situ	ADJ
admet-2214	777	3	targeting	target	VERB
admet-2214	777	4	nanoparticles	nanoparticle	NOUN
admet-2214	777	5	-	-	PUNCT
admet-2214	777	6	hydrogel	hydrogel	NOUN
admet-2214	777	7	hybrid	hybrid	NOUN
admet-2214	777	8	system	system	NOUN
admet-2214	777	9	for	for	ADP
admet-2214	777	10	combined	combined	ADJ
admet-2214	777	11	chemo	chemo	NOUN
admet-2214	777	12	-	-	PUNCT
admet-2214	777	13	immunotherapy	immunotherapy	NOUN
admet-2214	777	14	of	of	ADP
admet-2214	777	15	glioma	glioma	NOUN
admet-2214	777	16	.	.	PUNCT
admet-2214	778	1	journal	journal	PROPN
admet-2214	778	2	of	of	ADP
admet-2214	778	3	controlled	control	VERB
admet-2214	778	4	release	release	NOUN
admet-2214	778	5	(	(	PUNCT
admet-2214	778	6	2022	2022	NUM
admet-2214	778	7	)	)	PUNCT
admet-2214	778	8	786797	786797	NUM
admet-2214	779	1	https://doi.org/10.1016/j.jconrel.2022.03.050	https://doi.org/10.1016/j.jconrel.2022.03.050	PRON
admet-2214	780	1	[	[	X
admet-2214	780	2	102	102	NUM
admet-2214	780	3	]	]	X
admet-2214	780	4	k.	k.	PROPN
admet-2214	780	5	shi	shi	PROPN
admet-2214	780	6	,	,	PUNCT
admet-2214	780	7	j.	j.	PROPN
admet-2214	780	8	zhou	zhou	PROPN
admet-2214	780	9	,	,	PUNCT
admet-2214	780	10	q.	q.	PROPN
admet-2214	780	11	zhang	zhang	PROPN
admet-2214	780	12	,	,	PUNCT
admet-2214	780	13	h.	h.	PROPN
admet-2214	780	14	gao	gao	PROPN
admet-2214	780	15	,	,	PUNCT
admet-2214	780	16	y.	y.	PROPN
admet-2214	780	17	liu	liu	PROPN
admet-2214	780	18	,	,	PUNCT
admet-2214	780	19	t.	t.	PROPN
admet-2214	780	20	zong	zong	PROPN
admet-2214	780	21	,	,	PUNCT
admet-2214	780	22	q.	q.	PROPN
admet-2214	780	23	he	he	PRON
admet-2214	780	24	.	.	PUNCT
admet-2214	781	1	arginine	arginine	NOUN
admet-2214	781	2	-	-	PUNCT
admet-2214	781	3	glycine	glycine	NOUN
admet-2214	781	4	-	-	PUNCT
admet-2214	781	5	aspartic	aspartic	ADJ
admet-2214	781	6	acid	acid	NOUN
admet-2214	781	7	-	-	PUNCT
admet-2214	781	8	modified	modify	VERB
admet-2214	781	9	lipidpolymer	lipidpolymer	NOUN
admet-2214	781	10	hybrid	hybrid	NOUN
admet-2214	781	11	nanoparticles	nanoparticle	NOUN
admet-2214	781	12	for	for	ADP
admet-2214	781	13	docetaxel	docetaxel	NOUN
admet-2214	781	14	delivery	delivery	NOUN
admet-2214	781	15	in	in	ADP
admet-2214	781	16	glioblastoma	glioblastoma	NOUN
admet-2214	781	17	multiforme	multiforme	NOUN
admet-2214	781	18	.	.	PUNCT
admet-2214	782	1	journal	journal	PROPN
admet-2214	782	2	of	of	ADP
admet-2214	782	3	biomedical	biomedical	ADJ
admet-2214	782	4	nanotechnology	nanotechnology	NOUN
admet-2214	782	5	11	11	NUM
admet-2214	782	6	(	(	PUNCT
admet-2214	782	7	2015	2015	NUM
admet-2214	782	8	)	)	PUNCT
admet-2214	782	9	382	382	NUM
admet-2214	782	10	-	-	SYM
admet-2214	782	11	391	391	NUM
admet-2214	782	12	.	.	PUNCT
admet-2214	783	1	https://doi.org/10.1166/jbn.2015.1965	https://doi.org/10.1166/jbn.2015.1965	PRON
admet-2214	783	2	[	[	X
admet-2214	783	3	103	103	NUM
admet-2214	783	4	]	]	X
admet-2214	783	5	r.	r.	PROPN
admet-2214	783	6	marchan	marchan	PROPN
admet-2214	783	7	,	,	PUNCT
admet-2214	783	8	r.	r.	PROPN
admet-2214	783	9	reif	reif	PROPN
admet-2214	783	10	,	,	PUNCT
admet-2214	783	11	j.g	j.g	PROPN
admet-2214	783	12	.	.	PROPN
admet-2214	783	13	hengstler	hengstler	PROPN
admet-2214	783	14	.	.	PUNCT
admet-2214	784	1	toxicology	toxicology	NOUN
admet-2214	784	2	of	of	ADP
admet-2214	784	3	magnetic	magnetic	ADJ
admet-2214	784	4	nanoparticles	nanoparticle	NOUN
admet-2214	784	5	:	:	PUNCT
admet-2214	784	6	disturbed	disturbed	ADJ
admet-2214	784	7	body	body	NOUN
admet-2214	784	8	iron	iron	NOUN
admet-2214	784	9	homeostasis	homeostasis	NOUN
admet-2214	784	10	?	?	PUNCT
admet-2214	785	1	archives	archive	NOUN
admet-2214	785	2	of	of	ADP
admet-2214	785	3	toxicology	toxicology	NOUN
admet-2214	785	4	86	86	NUM
admet-2214	785	5	(	(	PUNCT
admet-2214	785	6	2012	2012	NUM
admet-2214	785	7	)	)	PUNCT
admet-2214	785	8	683	683	NUM
admet-2214	785	9	-	-	SYM
admet-2214	785	10	684	684	NUM
admet-2214	785	11	.	.	PUNCT
admet-2214	785	12	https://doi.org/10.1007/s00204-012-0850-2	https://doi.org/10.1007/s00204-012-0850-2	PUNCT
admet-2214	786	1	[	[	X
admet-2214	786	2	104	104	X
admet-2214	786	3	]	]	X
admet-2214	786	4	s.	s.	PROPN
admet-2214	786	5	doktorovová	doktorovová	PROPN
admet-2214	786	6	,	,	PUNCT
admet-2214	786	7	a.b	a.b	PROPN
admet-2214	786	8	.	.	PROPN
admet-2214	786	9	kovačević	kovačević	PROPN
admet-2214	786	10	,	,	PUNCT
admet-2214	786	11	m.l	m.l	PROPN
admet-2214	786	12	.	.	PUNCT
admet-2214	786	13	garcia	garcia	PROPN
admet-2214	786	14	,	,	PUNCT
admet-2214	786	15	e.b	e.b	PROPN
admet-2214	786	16	.	.	PROPN
admet-2214	786	17	souto	souto	PROPN
admet-2214	786	18	.	.	PUNCT
admet-2214	787	1	preclinical	preclinical	ADJ
admet-2214	787	2	safety	safety	NOUN
admet-2214	787	3	of	of	ADP
admet-2214	787	4	solid	solid	ADJ
admet-2214	787	5	lipid	lipid	NOUN
admet-2214	787	6	nanoparticles	nanoparticle	NOUN
admet-2214	787	7	and	and	CCONJ
admet-2214	787	8	nanostructured	nanostructure	VERB
admet-2214	787	9	lipid	lipid	NOUN
admet-2214	787	10	carriers	carrier	NOUN
admet-2214	787	11	:	:	PUNCT
admet-2214	787	12	current	current	ADJ
admet-2214	787	13	evidence	evidence	NOUN
admet-2214	787	14	from	from	ADP
admet-2214	787	15	in	in	ADP
admet-2214	787	16	vitro	vitro	X
admet-2214	787	17	and	and	CCONJ
admet-2214	787	18	in	in	ADP
admet-2214	787	19	vivo	vivo	ADJ
admet-2214	787	20	evaluation	evaluation	NOUN
admet-2214	787	21	.	.	PUNCT
admet-2214	788	1	european	european	ADJ
admet-2214	788	2	journal	journal	PROPN
admet-2214	788	3	of	of	ADP
admet-2214	788	4	pharmaceutics	pharmaceutic	NOUN
admet-2214	788	5	and	and	CCONJ
admet-2214	788	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2214	788	7	108	108	NUM
admet-2214	788	8	(	(	PUNCT
admet-2214	788	9	2016	2016	NUM
admet-2214	788	10	)	)	PUNCT
admet-2214	788	11	235	235	NUM
admet-2214	788	12	-	-	SYM
admet-2214	788	13	252	252	NUM
admet-2214	788	14	.	.	PUNCT
admet-2214	789	1	https://doi.org/10.1016/j.ejpb.2016.08.001	https://doi.org/10.1016/j.ejpb.2016.08.001	PRON
admet-2214	789	2	[	[	X
admet-2214	789	3	105	105	NUM
admet-2214	789	4	]	]	X
admet-2214	789	5	s.	s.	PROPN
admet-2214	789	6	doktorovova	doktorovova	PROPN
admet-2214	789	7	,	,	PUNCT
admet-2214	789	8	e.b	e.b	PROPN
admet-2214	789	9	.	.	PROPN
admet-2214	789	10	souto	souto	PROPN
admet-2214	789	11	,	,	PUNCT
admet-2214	789	12	a.m.	a.m.	PROPN
admet-2214	789	13	silva	silva	PROPN
admet-2214	789	14	.	.	PUNCT
admet-2214	790	1	nanotoxicology	nanotoxicology	NOUN
admet-2214	790	2	applied	apply	VERB
admet-2214	790	3	to	to	ADP
admet-2214	790	4	solid	solid	ADJ
admet-2214	790	5	lipid	lipid	ADJ
admet-2214	790	6	nanoparticles	nanoparticle	NOUN
admet-2214	790	7	and	and	CCONJ
admet-2214	790	8	nanostructured	nanostructure	VERB
admet-2214	790	9	lipid	lipid	NOUN
admet-2214	790	10	carriers	carrier	NOUN
admet-2214	790	11	a	a	DET
admet-2214	790	12	systematic	systematic	ADJ
admet-2214	790	13	review	review	NOUN
admet-2214	790	14	of	of	ADP
admet-2214	790	15	in	in	ADP
admet-2214	790	16	vitro	vitro	X
admet-2214	790	17	data	datum	NOUN
admet-2214	790	18	.	.	PUNCT
admet-2214	791	1	european	european	PROPN
admet-2214	791	2	journal	journal	PROPN
admet-2214	791	3	of	of	ADP
admet-2214	791	4	pharmaceutics	pharmaceutic	NOUN
admet-2214	791	5	and	and	CCONJ
admet-2214	791	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2214	791	7	87	87	NUM
admet-2214	791	8	(	(	PUNCT
admet-2214	791	9	2014	2014	NUM
admet-2214	791	10	)	)	PUNCT
admet-2214	791	11	1	1	NUM
admet-2214	791	12	-	-	SYM
admet-2214	791	13	18	18	NUM
admet-2214	791	14	.	.	PUNCT
admet-2214	792	1	https://doi.org/10.1016/j.ejpb.2014.02.005	https://doi.org/10.1016/j.ejpb.2014.02.005	PROPN
admet-2214	792	2	[	[	X
admet-2214	792	3	106	106	NUM
admet-2214	792	4	]	]	X
admet-2214	792	5	h.y	h.y	PROPN
admet-2214	792	6	.	.	PROPN
admet-2214	792	7	xue	xue	PROPN
admet-2214	792	8	,	,	PUNCT
admet-2214	792	9	s.	s.	PROPN
admet-2214	792	10	liu	liu	PROPN
admet-2214	792	11	,	,	PUNCT
admet-2214	792	12	h.l	h.l	PROPN
admet-2214	792	13	.	.	PROPN
admet-2214	792	14	wong	wong	PROPN
admet-2214	792	15	.	.	PROPN
admet-2214	792	16	nanotoxicity	nanotoxicity	PROPN
admet-2214	792	17	:	:	PUNCT
admet-2214	792	18	a	a	DET
admet-2214	792	19	key	key	ADJ
admet-2214	792	20	obstacle	obstacle	NOUN
admet-2214	792	21	to	to	ADP
admet-2214	792	22	clinical	clinical	ADJ
admet-2214	792	23	translation	translation	NOUN
admet-2214	792	24	of	of	ADP
admet-2214	792	25	sirna	sirna	PROPN
admet-2214	792	26	-	-	PUNCT
admet-2214	792	27	based	base	VERB
admet-2214	792	28	nanomedicine	nanomedicine	NOUN
admet-2214	792	29	.	.	PUNCT
admet-2214	793	1	nanomedicine	nanomedicine	NOUN
admet-2214	793	2	9	9	NUM
admet-2214	793	3	(	(	PUNCT
admet-2214	793	4	2014	2014	NUM
admet-2214	793	5	)	)	PUNCT
admet-2214	793	6	295	295	NUM
admet-2214	793	7	-	-	SYM
admet-2214	793	8	312	312	NUM
admet-2214	793	9	.	.	PUNCT
admet-2214	794	1	https://doi.org/10.2217/nnm.13.204	https://doi.org/10.2217/nnm.13.204	PROPN
admet-2214	795	1	[	[	X
admet-2214	795	2	107	107	NUM
admet-2214	795	3	]	]	X
admet-2214	795	4	j.e.n	j.e.n	ADJ
admet-2214	795	5	.	.	PUNCT
admet-2214	795	6	dolatabadi	dolatabadi	NOUN
admet-2214	795	7	,	,	PUNCT
admet-2214	795	8	h.	h.	PROPN
admet-2214	795	9	hamishehkar	hamishehkar	PROPN
admet-2214	795	10	,	,	PUNCT
admet-2214	795	11	m.	m.	NOUN
admet-2214	795	12	eskandani	eskandani	NOUN
admet-2214	795	13	,	,	PUNCT
admet-2214	795	14	h.	h.	PROPN
admet-2214	795	15	valizadeh	valizadeh	PROPN
admet-2214	795	16	.	.	PUNCT
admet-2214	796	1	formulation	formulation	NOUN
admet-2214	796	2	,	,	PUNCT
admet-2214	796	3	characterization	characterization	NOUN
admet-2214	796	4	and	and	CCONJ
admet-2214	796	5	cytotoxicity	cytotoxicity	NOUN
admet-2214	796	6	studies	study	NOUN
admet-2214	796	7	of	of	ADP
admet-2214	796	8	alendronate	alendronate	PROPN
admet-2214	796	9	sodium	sodium	NOUN
admet-2214	796	10	-	-	PUNCT
admet-2214	796	11	loaded	load	VERB
admet-2214	796	12	solid	solid	ADJ
admet-2214	796	13	lipid	lipid	NOUN
admet-2214	796	14	nanoparticles	nanoparticle	NOUN
admet-2214	796	15	.	.	PUNCT
admet-2214	797	1	colloids	colloid	NOUN
admet-2214	797	2	and	and	CCONJ
admet-2214	797	3	surfaces	surface	NOUN
admet-2214	797	4	b	b	NUM
admet-2214	797	5	:	:	PUNCT
admet-2214	797	6	biointerfaces	biointerface	NOUN
admet-2214	797	7	117	117	NUM
admet-2214	797	8	(	(	PUNCT
admet-2214	797	9	2014	2014	NUM
admet-2214	797	10	)	)	PUNCT
admet-2214	797	11	21	21	NUM
admet-2214	797	12	-	-	SYM
admet-2214	797	13	28	28	NUM
admet-2214	797	14	.	.	PUNCT
admet-2214	798	1	https://doi.org/10.1016/j.colsurfb.2014.01.055	https://doi.org/10.1016/j.colsurfb.2014.01.055	PROPN
admet-2214	799	1	[	[	X
admet-2214	799	2	108	108	NUM
admet-2214	799	3	]	]	PUNCT
admet-2214	799	4	s.	s.	PROPN
admet-2214	799	5	bhushan	bhushan	PROPN
admet-2214	799	6	,	,	PUNCT
admet-2214	799	7	v.	v.	CCONJ
admet-2214	799	8	kakkar	kakkar	PROPN
admet-2214	799	9	,	,	PUNCT
admet-2214	799	10	h.c	h.c	PROPN
admet-2214	799	11	.	.	PROPN
admet-2214	799	12	pal	pal	PROPN
admet-2214	799	13	,	,	PUNCT
admet-2214	799	14	d.m	d.m	PROPN
admet-2214	799	15	.	.	PROPN
admet-2214	799	16	mondhe	mondhe	PROPN
admet-2214	799	17	,	,	PUNCT
admet-2214	799	18	i.p	i.p	PROPN
admet-2214	799	19	.	.	PROPN
admet-2214	799	20	kaur	kaur	PROPN
admet-2214	799	21	.	.	PUNCT
admet-2214	800	1	the	the	DET
admet-2214	800	2	augmented	augment	VERB
admet-2214	800	3	anticancer	anticancer	NOUN
admet-2214	800	4	potential	potential	NOUN
admet-2214	800	5	of	of	ADP
admet-2214	800	6	ap9	ap9	PROPN
admet-2214	800	7	-	-	PUNCT
admet-2214	800	8	cd	cd	NOUN
admet-2214	800	9	loaded	load	VERB
admet-2214	800	10	solid	solid	ADJ
admet-2214	800	11	lipid	lipid	NOUN
admet-2214	800	12	nanoparticles	nanoparticle	NOUN
admet-2214	800	13	in	in	ADP
admet-2214	800	14	human	human	ADJ
admet-2214	800	15	leukemia	leukemia	NOUN
admet-2214	800	16	molt-4	molt-4	NUM
admet-2214	800	17	cells	cell	NOUN
admet-2214	800	18	and	and	CCONJ
admet-2214	800	19	experimental	experimental	ADJ
admet-2214	800	20	tumor	tumor	NOUN
admet-2214	800	21	.	.	PUNCT
admet-2214	801	1	chemico	chemico	ADJ
admet-2214	801	2	-	-	ADJ
admet-2214	801	3	biological	biological	ADJ
admet-2214	801	4	interactions	interaction	NOUN
admet-2214	801	5	244	244	NUM
admet-2214	801	6	(	(	PUNCT
admet-2214	801	7	2016	2016	NUM
admet-2214	801	8	)	)	PUNCT
admet-2214	801	9	84	84	NUM
admet-2214	801	10	-	-	SYM
admet-2214	801	11	93	93	NUM
admet-2214	801	12	.	.	PUNCT
admet-2214	802	1	https://doi.org/10.1016/j.cbi.2015.11.022	https://doi.org/10.1016/j.cbi.2015.11.022	PROPN
admet-2214	803	1	[	[	X
admet-2214	803	2	109	109	NUM
admet-2214	803	3	]	]	PUNCT
admet-2214	803	4	m.	m.	NOUN
admet-2214	803	5	eskandani	eskandani	NOUN
admet-2214	803	6	,	,	PUNCT
admet-2214	803	7	h.	h.	PROPN
admet-2214	803	8	nazemiyeh	nazemiyeh	PROPN
admet-2214	803	9	.	.	PUNCT
admet-2214	804	1	european	european	PROPN
admet-2214	804	2	journal	journal	PROPN
admet-2214	804	3	of	of	ADP
admet-2214	804	4	pharmaceutical	pharmaceutical	PROPN
admet-2214	804	5	sciences	science	NOUN
admet-2214	804	6	self	self	NOUN
admet-2214	804	7	-	-	PUNCT
admet-2214	804	8	reporter	reporter	NOUN
admet-2214	804	9	shikoninact	shikoninact	NOUN
admet-2214	804	10	-	-	PUNCT
admet-2214	804	11	loaded	load	VERB
admet-2214	804	12	solid	solid	ADJ
admet-2214	804	13	lipid	lipid	NOUN
admet-2214	804	14	nanoparticle	nanoparticle	NOUN
admet-2214	804	15	 	 	SPACE
admet-2214	804	16	:	:	PUNCT
admet-2214	804	17	formulation	formulation	NOUN
admet-2214	804	18	,	,	PUNCT
admet-2214	804	19	physicochemical	physicochemical	ADJ
admet-2214	804	20	characterization	characterization	NOUN
admet-2214	804	21	and	and	CCONJ
admet-2214	804	22	geno	geno	NOUN
admet-2214	804	23	/	/	SYM
admet-2214	804	24	cytotoxicity	cytotoxicity	NOUN
admet-2214	804	25	evaluation	evaluation	NOUN
admet-2214	804	26	.	.	PUNCT
admet-2214	805	1	european	european	ADJ
admet-2214	805	2	journal	journal	PROPN
admet-2214	805	3	of	of	ADP
admet-2214	805	4	pharmaceutical	pharmaceutical	PROPN
admet-2214	805	5	sciences	science	NOUN
admet-2214	805	6	59	59	NUM
admet-2214	805	7	(	(	PUNCT
admet-2214	805	8	2014	2014	NUM
admet-2214	805	9	)	)	PUNCT
admet-2214	805	10	49	49	NUM
admet-2214	805	11	-	-	SYM
admet-2214	805	12	57	57	NUM
admet-2214	805	13	.	.	PUNCT
admet-2214	806	1	https://doi.org/10.1016/j.ejps.2014.04.009	https://doi.org/10.1016/j.ejps.2014.04.009	X
admet-2214	806	2	https://doi.org/10.1016/j.jconrel.2022.03.019	https://doi.org/10.1016/j.jconrel.2022.03.019	NUM
admet-2214	806	3	https://doi.org/10.1007/s10856-021-06538-2	https://doi.org/10.1007/s10856-021-06538-2	NUM
admet-2214	806	4	https://doi.org/10.3109/10717544.2016.1141258	https://doi.org/10.3109/10717544.2016.1141258	PROPN
admet-2214	807	1	https://doi.org/10.1016/j.biopha.2021.112249	https://doi.org/10.1016/j.biopha.2021.112249	PROPN
admet-2214	807	2	https://doi.org/10.2147/ijn.s198353	https://doi.org/10.2147/ijn.s198353	NUM
admet-2214	807	3	https://doi.org/10.1016/j.ejpb.2013.07.002	https://doi.org/10.1016/j.ejpb.2013.07.002	NOUN
admet-2214	807	4	https://doi.org/10.1016/j.mimet.2019.03.017	https://doi.org/10.1016/j.mimet.2019.03.017	PROPN
admet-2214	807	5	https://doi.org/10.1016/j.jconrel.2022.03.050	https://doi.org/10.1016/j.jconrel.2022.03.050	PROPN
admet-2214	807	6	https://doi.org/10.1166/jbn.2015.1965	https://doi.org/10.1166/jbn.2015.1965	PROPN
admet-2214	807	7	https://doi.org/10.1007/s00204-012-0850-2	https://doi.org/10.1007/s00204-012-0850-2	PROPN
admet-2214	807	8	https://doi.org/10.1016/j.ejpb.2016.08.001	https://doi.org/10.1016/j.ejpb.2016.08.001	PROPN
admet-2214	807	9	https://doi.org/10.1016/j.ejpb.2016.08.001	https://doi.org/10.1016/j.ejpb.2016.08.001	NUM
admet-2214	807	10	https://doi.org/10.1016/j.ejpb.2014.02.005	https://doi.org/10.1016/j.ejpb.2014.02.005	PROPN
admet-2214	807	11	.	.	PUNCT
admet-2214	808	1	https://doi.org/10.2217/nnm.13.204	https://doi.org/10.2217/nnm.13.204	PROPN
admet-2214	808	2	https://doi.org/10.1016/j.colsurfb.2014.01.055	https://doi.org/10.1016/j.colsurfb.2014.01.055	PROPN
admet-2214	808	3	https://doi.org/10.1016/j.cbi.2015.11.022	https://doi.org/10.1016/j.cbi.2015.11.022	PROPN
admet-2214	808	4	https://doi.org/10.1016/j.ejps.2014.04.009	https://doi.org/10.1016/j.ejps.2014.04.009	PROPN
admet-2214	808	5	admet	admet	PROPN
admet-2214	808	6	&	&	CCONJ
admet-2214	808	7	dmpk	dmpk	PROPN
admet-2214	808	8	12(3	12(3	PROPN
admet-2214	808	9	)	)	PUNCT
admet-2214	808	10	(	(	PUNCT
admet-2214	808	11	2024	2024	NUM
admet-2214	808	12	)	)	PUNCT
admet-2214	808	13	403	403	NUM
admet-2214	808	14	-	-	SYM
admet-2214	808	15	429	429	NUM
admet-2214	808	16	addressing	address	VERB
admet-2214	808	17	barriers	barrier	NOUN
admet-2214	808	18	in	in	ADP
admet-2214	808	19	diffuse	diffuse	ADJ
admet-2214	808	20	intrinsic	intrinsic	ADJ
admet-2214	808	21	pontine	pontine	ADJ
admet-2214	808	22	glioma	glioma	NOUN
admet-2214	808	23	doi	doi	NOUN
admet-2214	808	24	:	:	PUNCT
admet-2214	808	25	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	X
admet-2214	808	26	429	429	NUM
admet-2214	809	1	[	[	SYM
admet-2214	809	2	110	110	NUM
admet-2214	809	3	]	]	X
admet-2214	809	4	s.	s.	PROPN
admet-2214	809	5	lakkadwala	lakkadwala	PROPN
admet-2214	809	6	,	,	PUNCT
admet-2214	809	7	s.	s.	PROPN
admet-2214	809	8	nguyen	nguyen	PROPN
admet-2214	809	9	,	,	PUNCT
admet-2214	809	10	j.	j.	PROPN
admet-2214	809	11	lawrence	lawrence	PROPN
admet-2214	809	12	,	,	PUNCT
admet-2214	809	13	s.m	s.m	PROPN
admet-2214	809	14	.	.	PROPN
admet-2214	809	15	nauli	nauli	PROPN
admet-2214	809	16	,	,	PUNCT
admet-2214	809	17	j.	j.	PROPN
admet-2214	809	18	nesamony	nesamony	PROPN
admet-2214	809	19	.	.	PUNCT
admet-2214	810	1	physico	physico	NOUN
admet-2214	810	2	-	-	PUNCT
admet-2214	810	3	chemical	chemical	NOUN
admet-2214	810	4	characterisation	characterisation	NOUN
admet-2214	810	5	,	,	PUNCT
admet-2214	810	6	cytotoxic	cytotoxic	ADJ
admet-2214	810	7	activity	activity	NOUN
admet-2214	810	8	,	,	PUNCT
admet-2214	810	9	and	and	CCONJ
admet-2214	810	10	biocompatibility	biocompatibility	NOUN
admet-2214	810	11	studies	study	NOUN
admet-2214	810	12	of	of	ADP
admet-2214	810	13	tamoxifen	tamoxifen	NOUN
admet-2214	810	14	-	-	PUNCT
admet-2214	810	15	loaded	load	VERB
admet-2214	810	16	solid	solid	ADJ
admet-2214	810	17	lipid	lipid	NOUN
admet-2214	810	18	nanoparticles	nanoparticle	NOUN
admet-2214	810	19	prepared	prepare	VERB
admet-2214	810	20	via	via	ADP
admet-2214	810	21	a	a	DET
admet-2214	810	22	temperature	temperature	NOUN
admet-2214	810	23	-	-	PUNCT
admet-2214	810	24	modulated	modulate	VERB
admet-2214	810	25	solidification	solidification	NOUN
admet-2214	810	26	method	method	NOUN
admet-2214	810	27	.	.	PUNCT
admet-2214	811	1	journal	journal	NOUN
admet-2214	811	2	of	of	ADP
admet-2214	811	3	microencapsulation	microencapsulation	NOUN
admet-2214	811	4	31	31	NUM
admet-2214	811	5	(	(	PUNCT
admet-2214	811	6	2014	2014	NUM
admet-2214	811	7	)	)	PUNCT
admet-2214	811	8	590	590	NUM
admet-2214	811	9	-	-	SYM
admet-2214	811	10	599	599	NUM
admet-2214	811	11	.	.	PUNCT
admet-2214	812	1	https://doi.org/10.3109/02652048.2014.898707	https://doi.org/10.3109/02652048.2014.898707	PUNCT
admet-2214	813	1	[	[	X
admet-2214	813	2	111	111	NUM
admet-2214	813	3	]	]	PUNCT
admet-2214	813	4	f.	f.	PROPN
admet-2214	813	5	farjadian	farjadian	PROPN
admet-2214	813	6	,	,	PUNCT
admet-2214	813	7	a.	a.	NOUN
admet-2214	813	8	ghasemi	ghasemi	PROPN
admet-2214	813	9	,	,	PUNCT
admet-2214	813	10	o.	o.	PROPN
admet-2214	813	11	gohari	gohari	PROPN
admet-2214	813	12	,	,	PUNCT
admet-2214	813	13	a.	a.	PROPN
admet-2214	813	14	roointan	roointan	PROPN
admet-2214	813	15	,	,	PUNCT
admet-2214	813	16	m.	m.	PROPN
admet-2214	813	17	karimi	karimi	PROPN
admet-2214	813	18	,	,	PUNCT
admet-2214	813	19	m.r	m.r	PROPN
admet-2214	813	20	.	.	PROPN
admet-2214	813	21	hamblin	hamblin	PROPN
admet-2214	813	22	.	.	PUNCT
admet-2214	814	1	nanopharmaceuticals	nanopharmaceutical	NOUN
admet-2214	814	2	and	and	CCONJ
admet-2214	814	3	nanomedicines	nanomedicine	NOUN
admet-2214	814	4	currently	currently	ADV
admet-2214	814	5	on	on	ADP
admet-2214	814	6	the	the	DET
admet-2214	814	7	market	market	NOUN
admet-2214	814	8	:	:	PUNCT
admet-2214	814	9	challenges	challenge	NOUN
admet-2214	814	10	and	and	CCONJ
admet-2214	814	11	opportunities	opportunity	NOUN
admet-2214	814	12	.	.	PUNCT
admet-2214	815	1	nanomedicine	nanomedicine	NOUN
admet-2214	815	2	14(1	14(1	NUM
admet-2214	815	3	)	)	PUNCT
admet-2214	815	4	(	(	PUNCT
admet-2214	815	5	2019	2019	NUM
admet-2214	815	6	)	)	PUNCT
admet-2214	815	7	96	96	NUM
admet-2214	815	8	-	-	SYM
admet-2214	815	9	126	126	NUM
admet-2214	815	10	.	.	PUNCT
admet-2214	815	11	https://doi.org/10.2217/nnm-2018-0120	https://doi.org/10.2217/nnm-2018-0120	ADJ
admet-2214	815	12	[	[	X
admet-2214	815	13	112	112	NUM
admet-2214	815	14	]	]	PUNCT
admet-2214	815	15	m.	m.	NOUN
admet-2214	815	16	zhao	zhao	PROPN
admet-2214	815	17	,	,	PUNCT
admet-2214	815	18	h.	h.	PROPN
admet-2214	815	19	li	li	PROPN
admet-2214	815	20	,	,	PUNCT
admet-2214	815	21	l.	l.	PROPN
admet-2214	815	22	fan	fan	PROPN
admet-2214	815	23	,	,	PUNCT
admet-2214	815	24	y.	y.	PROPN
admet-2214	815	25	ma	ma	PROPN
admet-2214	815	26	,	,	PUNCT
admet-2214	815	27	h.	h.	PROPN
admet-2214	815	28	gong	gong	PROPN
admet-2214	815	29	,	,	PUNCT
admet-2214	815	30	w.	w.	PROPN
admet-2214	815	31	lai	lai	PROPN
admet-2214	815	32	,	,	PUNCT
admet-2214	815	33	q.	q.	PROPN
admet-2214	815	34	fang	fang	PROPN
admet-2214	815	35	,	,	PUNCT
admet-2214	815	36	z.	z.	PROPN
admet-2214	815	37	hu	hu	PROPN
admet-2214	815	38	.	.	PROPN
admet-2214	816	1	quantitative	quantitative	ADJ
admet-2214	816	2	proteomic	proteomic	ADJ
admet-2214	816	3	analysis	analysis	NOUN
admet-2214	816	4	to	to	ADP
admet-2214	816	5	the	the	DET
admet-2214	816	6	first	first	ADJ
admet-2214	816	7	commercialized	commercialize	VERB
admet-2214	816	8	liposomal	liposomal	ADJ
admet-2214	816	9	paclitaxel	paclitaxel	PROPN
admet-2214	816	10	nano	nano	NOUN
admet-2214	816	11	-	-	PUNCT
admet-2214	816	12	platform	platform	NOUN
admet-2214	816	13	lipusu	lipusu	NOUN
admet-2214	816	14	revealed	reveal	VERB
admet-2214	816	15	the	the	DET
admet-2214	816	16	molecular	molecular	ADJ
admet-2214	816	17	mechanism	mechanism	NOUN
admet-2214	816	18	of	of	ADP
admet-2214	816	19	the	the	DET
admet-2214	816	20	enhanced	enhanced	ADJ
admet-2214	816	21	anti	anti	ADJ
admet-2214	816	22	-	-	ADJ
admet-2214	816	23	tumor	tumor	ADJ
admet-2214	816	24	effect	effect	NOUN
admet-2214	816	25	.	.	PUNCT
admet-2214	817	1	artificial	artificial	ADJ
admet-2214	817	2	cells	cell	NOUN
admet-2214	817	3	,	,	PUNCT
admet-2214	817	4	nanomedicine	nanomedicine	NOUN
admet-2214	817	5	and	and	CCONJ
admet-2214	817	6	biotechnology	biotechnology	NOUN
admet-2214	817	7	46	46	NUM
admet-2214	817	8	(	(	PUNCT
admet-2214	817	9	2018	2018	NUM
admet-2214	817	10	)	)	PUNCT
admet-2214	817	11	147155	147155	NUM
admet-2214	817	12	.	.	PUNCT
admet-2214	818	1	https://doi.org/10.1080/21691401.2018.1489822	https://doi.org/10.1080/21691401.2018.1489822	NOUN
admet-2214	819	1	[	[	X
admet-2214	819	2	113	113	NUM
admet-2214	819	3	]	]	X
admet-2214	819	4	y.	y.	PROPN
admet-2214	819	5	barenholz	barenholz	PROPN
admet-2214	819	6	.	.	PUNCT
admet-2214	820	1	doxil	doxil	PROPN
admet-2214	820	2	®	®	PROPN
admet-2214	820	3	the	the	DET
admet-2214	820	4	first	first	ADJ
admet-2214	820	5	fda	fda	PROPN
admet-2214	820	6	-	-	PUNCT
admet-2214	820	7	approved	approve	VERB
admet-2214	820	8	nano	nano	NOUN
admet-2214	820	9	-	-	PUNCT
admet-2214	820	10	drug	drug	NOUN
admet-2214	820	11	:	:	PUNCT
admet-2214	820	12	lessons	lesson	NOUN
admet-2214	820	13	learned	learn	VERB
admet-2214	820	14	.	.	PUNCT
admet-2214	821	1	journal	journal	PROPN
admet-2214	821	2	of	of	ADP
admet-2214	821	3	controlled	control	VERB
admet-2214	821	4	release	release	NOUN
admet-2214	821	5	160	160	NUM
admet-2214	821	6	(	(	PUNCT
admet-2214	821	7	2012	2012	NUM
admet-2214	821	8	)	)	PUNCT
admet-2214	821	9	117	117	NUM
admet-2214	821	10	-	-	SYM
admet-2214	821	11	134	134	NUM
admet-2214	821	12	.	.	PUNCT
admet-2214	822	1	https://doi.org/10.1016/j.jconrel.2012.03.020	https://doi.org/10.1016/j.jconrel.2012.03.020	NOUN
admet-2214	822	2	[	[	X
admet-2214	823	1	114	114	NUM
admet-2214	823	2	]	]	X
admet-2214	823	3	g.m	g.m	PROPN
admet-2214	823	4	.	.	PUNCT
admet-2214	823	5	jensen	jensen	PROPN
admet-2214	823	6	,	,	PUNCT
admet-2214	823	7	d.f	d.f	PROPN
admet-2214	823	8	.	.	PROPN
admet-2214	823	9	hodgson	hodgson	PROPN
admet-2214	823	10	.	.	PUNCT
admet-2214	824	1	opportunities	opportunity	NOUN
admet-2214	824	2	and	and	CCONJ
admet-2214	824	3	challenges	challenge	NOUN
admet-2214	824	4	in	in	ADP
admet-2214	824	5	commercial	commercial	ADJ
admet-2214	824	6	pharmaceutical	pharmaceutical	NOUN
admet-2214	824	7	liposome	liposome	NOUN
admet-2214	824	8	applications	application	NOUN
admet-2214	824	9	.	.	PUNCT
admet-2214	825	1	advanced	advanced	ADJ
admet-2214	825	2	drug	drug	NOUN
admet-2214	825	3	delivery	delivery	NOUN
admet-2214	825	4	reviews	review	VERB
admet-2214	825	5	154	154	NUM
admet-2214	825	6	-	-	SYM
admet-2214	825	7	155	155	NUM
admet-2214	825	8	(	(	PUNCT
admet-2214	825	9	2020	2020	NUM
admet-2214	825	10	)	)	PUNCT
admet-2214	825	11	2	2	NUM
admet-2214	825	12	-	-	SYM
admet-2214	825	13	12	12	NUM
admet-2214	825	14	.	.	PUNCT
admet-2214	826	1	https://doi.org/10.1016/j.addr.2020.07.016	https://doi.org/10.1016/j.addr.2020.07.016	PROPN
admet-2214	826	2	[	[	X
admet-2214	826	3	115	115	NUM
admet-2214	826	4	]	]	PUNCT
admet-2214	826	5	a.	a.	NOUN
admet-2214	826	6	fassas	fassas	PROPN
admet-2214	826	7	,	,	PUNCT
admet-2214	826	8	a.	a.	NOUN
admet-2214	826	9	anagnostopoulos	anagnostopoulos	PROPN
admet-2214	826	10	.	.	PUNCT
admet-2214	827	1	the	the	DET
admet-2214	827	2	use	use	NOUN
admet-2214	827	3	of	of	ADP
admet-2214	827	4	liposomal	liposomal	ADJ
admet-2214	827	5	daunorubicin	daunorubicin	PROPN
admet-2214	827	6	(	(	PUNCT
admet-2214	827	7	daunoxome	daunoxome	PROPN
admet-2214	827	8	)	)	PUNCT
admet-2214	827	9	in	in	ADP
admet-2214	827	10	acute	acute	ADJ
admet-2214	827	11	myeloid	myeloid	ADJ
admet-2214	827	12	leukemia	leukemia	NOUN
admet-2214	827	13	.	.	PUNCT
admet-2214	828	1	leukemia	leukemia	NOUN
admet-2214	828	2	and	and	CCONJ
admet-2214	828	3	lymphoma	lymphoma	NOUN
admet-2214	828	4	46	46	NUM
admet-2214	828	5	(	(	PUNCT
admet-2214	828	6	2005	2005	NUM
admet-2214	828	7	)	)	PUNCT
admet-2214	828	8	795	795	NUM
admet-2214	828	9	-	-	SYM
admet-2214	828	10	802	802	NUM
admet-2214	828	11	.	.	PUNCT
admet-2214	829	1	https://doi.org/10.1080/10428190500052438	https://doi.org/10.1080/10428190500052438	X
admet-2214	830	1	[	[	X
admet-2214	830	2	116	116	X
admet-2214	830	3	]	]	X
admet-2214	830	4	l.	l.	PROPN
admet-2214	830	5	kager	kager	PROPN
admet-2214	830	6	,	,	PUNCT
admet-2214	830	7	pötschger	pötschger	NOUN
admet-2214	830	8	,	,	PUNCT
admet-2214	830	9	bielack	bielack	NOUN
admet-2214	830	10	.	.	PUNCT
admet-2214	831	1	review	review	NOUN
admet-2214	831	2	of	of	ADP
admet-2214	831	3	mifamurtide	mifamurtide	NOUN
admet-2214	831	4	in	in	ADP
admet-2214	831	5	the	the	DET
admet-2214	831	6	treatment	treatment	NOUN
admet-2214	831	7	of	of	ADP
admet-2214	831	8	patients	patient	NOUN
admet-2214	831	9	with	with	ADP
admet-2214	831	10	osteosarcoma	osteosarcoma	ADJ
admet-2214	831	11	.	.	PUNCT
admet-2214	832	1	therapeutics	therapeutic	NOUN
admet-2214	832	2	and	and	CCONJ
admet-2214	832	3	clinical	clinical	ADJ
admet-2214	832	4	risk	risk	NOUN
admet-2214	832	5	management	management	NOUN
admet-2214	832	6	6	6	NUM
admet-2214	832	7	(	(	PUNCT
admet-2214	832	8	2010	2010	NUM
admet-2214	832	9	)	)	PUNCT
admet-2214	832	10	279	279	NUM
admet-2214	832	11	-	-	SYM
admet-2214	832	12	286	286	NUM
admet-2214	832	13	.	.	PUNCT
admet-2214	833	1	https://doi.org/10.2147/tcrm.s5688	https://doi.org/10.2147/tcrm.s5688	X
admet-2214	834	1	[	[	X
admet-2214	834	2	117	117	NUM
admet-2214	834	3	]	]	PUNCT
admet-2214	834	4	k.	k.	PROPN
admet-2214	834	5	tzogani	tzogani	PROPN
admet-2214	834	6	,	,	PUNCT
admet-2214	834	7	m.	m.	NOUN
admet-2214	834	8	straube	straube	NOUN
admet-2214	834	9	,	,	PUNCT
admet-2214	834	10	u.	u.	PROPN
admet-2214	834	11	hoppe	hoppe	PROPN
admet-2214	834	12	,	,	PUNCT
admet-2214	834	13	p.	p.	PROPN
admet-2214	834	14	kiely	kiely	PROPN
admet-2214	834	15	,	,	PUNCT
admet-2214	834	16	g.	g.	PROPN
admet-2214	834	17	o’dea	o’dea	PROPN
admet-2214	834	18	,	,	PUNCT
admet-2214	834	19	h.	h.	NOUN
admet-2214	834	20	enzmann	enzmann	PROPN
admet-2214	834	21	,	,	PUNCT
admet-2214	834	22	p.	p.	NOUN
admet-2214	834	23	salmon	salmon	NOUN
admet-2214	834	24	,	,	PUNCT
admet-2214	834	25	t.	t.	NOUN
admet-2214	834	26	salmonson	salmonson	NOUN
admet-2214	834	27	,	,	PUNCT
admet-2214	834	28	f.	f.	PROPN
admet-2214	834	29	pignatti	pignatti	PROPN
admet-2214	834	30	.	.	PUNCT
admet-2214	835	1	the	the	DET
admet-2214	835	2	european	european	PROPN
admet-2214	835	3	medicines	medicines	PROPN
admet-2214	835	4	agency	agency	NOUN
admet-2214	835	5	approval	approval	NOUN
admet-2214	835	6	of	of	ADP
admet-2214	835	7	5	5	NUM
admet-2214	835	8	-	-	PUNCT
admet-2214	835	9	aminolaevulinic	aminolaevulinic	ADJ
admet-2214	835	10	acid	acid	NOUN
admet-2214	835	11	(	(	PUNCT
admet-2214	835	12	ameluz	ameluz	NOUN
admet-2214	835	13	)	)	PUNCT
admet-2214	835	14	for	for	ADP
admet-2214	835	15	the	the	DET
admet-2214	835	16	treatment	treatment	NOUN
admet-2214	835	17	of	of	ADP
admet-2214	835	18	actinic	actinic	ADJ
admet-2214	835	19	keratosis	keratosis	NOUN
admet-2214	835	20	of	of	ADP
admet-2214	835	21	mild	mild	NOUN
admet-2214	835	22	to	to	ADP
admet-2214	835	23	moderate	moderate	ADJ
admet-2214	835	24	intensity	intensity	NOUN
admet-2214	835	25	on	on	ADP
admet-2214	835	26	the	the	DET
admet-2214	835	27	face	face	NOUN
admet-2214	835	28	and	and	CCONJ
admet-2214	835	29	scalp	scalp	NOUN
admet-2214	835	30	:	:	PUNCT
admet-2214	835	31	summary	summary	NOUN
admet-2214	835	32	of	of	ADP
admet-2214	835	33	the	the	DET
admet-2214	835	34	scientific	scientific	ADJ
admet-2214	835	35	assessment	assessment	NOUN
admet-2214	835	36	of	of	ADP
admet-2214	835	37	the	the	DET
admet-2214	835	38	committee	committee	NOUN
admet-2214	835	39	for	for	ADP
admet-2214	835	40	medicinal	medicinal	ADJ
admet-2214	835	41	products	product	NOUN
admet-2214	835	42	for	for	ADP
admet-2214	835	43	human	human	PROPN
admet-2214	835	44	us	us	PROPN
admet-2214	835	45	.	.	PUNCT
admet-2214	836	1	journal	journal	PROPN
admet-2214	836	2	of	of	ADP
admet-2214	836	3	dermatological	dermatological	ADJ
admet-2214	836	4	treatment	treatment	NOUN
admet-2214	836	5	25	25	NUM
admet-2214	836	6	(	(	PUNCT
admet-2214	836	7	2014	2014	NUM
admet-2214	836	8	)	)	PUNCT
admet-2214	836	9	371	371	NUM
admet-2214	836	10	-	-	SYM
admet-2214	836	11	374	374	NUM
admet-2214	836	12	.	.	PUNCT
admet-2214	837	1	https://doi.org/10.3109/09546634.2013.789474	https://doi.org/10.3109/09546634.2013.789474	X
admet-2214	838	1	[	[	X
admet-2214	838	2	118	118	NUM
admet-2214	838	3	]	]	X
admet-2214	838	4	s.s	s.s	PROPN
admet-2214	838	5	.	.	PROPN
admet-2214	838	6	legha	legha	PROPN
admet-2214	838	7	.	.	PUNCT
admet-2214	839	1	vincristine	vincristine	NOUN
admet-2214	839	2	neurotoxicity	neurotoxicity	NOUN
admet-2214	839	3	:	:	PUNCT
admet-2214	839	4	pathophysiology	pathophysiology	NOUN
admet-2214	839	5	and	and	CCONJ
admet-2214	839	6	management	management	NOUN
admet-2214	839	7	.	.	PUNCT
admet-2214	840	1	medical	medical	ADJ
admet-2214	840	2	toxicology	toxicology	NOUN
admet-2214	840	3	1	1	NUM
admet-2214	840	4	(	(	PUNCT
admet-2214	840	5	1986	1986	NUM
admet-2214	840	6	)	)	PUNCT
admet-2214	840	7	421	421	NUM
admet-2214	840	8	-	-	SYM
admet-2214	840	9	427	427	NUM
admet-2214	840	10	.	.	PUNCT
admet-2214	840	11	https://doi.org/10.1007/bf03259853	https://doi.org/10.1007/bf03259853	PROPN
admet-2214	841	1	[	[	X
admet-2214	841	2	119	119	NUM
admet-2214	841	3	]	]	X
admet-2214	841	4	j.e	j.e	PROPN
admet-2214	841	5	.	.	PROPN
admet-2214	841	6	frampton	frampton	PROPN
admet-2214	841	7	.	.	PUNCT
admet-2214	842	1	liposomal	liposomal	PROPN
admet-2214	842	2	irinotecan	irinotecan	PROPN
admet-2214	842	3	:	:	PUNCT
admet-2214	842	4	a	a	DET
admet-2214	842	5	review	review	NOUN
admet-2214	842	6	in	in	ADP
admet-2214	842	7	metastatic	metastatic	ADJ
admet-2214	842	8	pancreatic	pancreatic	ADJ
admet-2214	842	9	adenocarcinoma	adenocarcinoma	NOUN
admet-2214	842	10	.	.	PUNCT
admet-2214	843	1	drugs	drug	NOUN
admet-2214	843	2	80	80	NUM
admet-2214	843	3	(	(	PUNCT
admet-2214	843	4	2020	2020	NUM
admet-2214	843	5	)	)	PUNCT
admet-2214	843	6	1007	1007	NUM
admet-2214	843	7	-	-	SYM
admet-2214	843	8	1018	1018	NUM
admet-2214	843	9	.	.	PUNCT
admet-2214	844	1	https://doi.org/10.1007/s40265-020-01336-6	https://doi.org/10.1007/s40265-020-01336-6	PUNCT
admet-2214	845	1	[	[	X
admet-2214	845	2	120	120	NUM
admet-2214	845	3	]	]	X
admet-2214	845	4	clinical	clinical	ADJ
admet-2214	845	5	studies	study	NOUN
admet-2214	845	6	.	.	PUNCT
admet-2214	846	1	https://clinicaltrials.gov/search?cond=diffuse	https://clinicaltrials.gov/search?cond=diffuse	PROPN
admet-2214	846	2	intrinsic	intrinsic	ADJ
admet-2214	846	3	pontine	pontine	ADJ
admet-2214	846	4	glioma	glioma	NOUN
admet-2214	846	5	accessed	access	VERB
admet-2214	846	6	on	on	ADP
admet-2214	846	7	20/10/2023	20/10/2023	NUM
admet-2214	846	8	.	.	PUNCT
admet-2214	847	1	©	©	PROPN
admet-2214	847	2	2024	2024	NUM
admet-2214	847	3	by	by	ADP
admet-2214	847	4	the	the	DET
admet-2214	847	5	authors	author	NOUN
admet-2214	847	6	;	;	PUNCT
admet-2214	847	7	licensee	licensee	PROPN
admet-2214	847	8	iapc	iapc	PROPN
admet-2214	847	9	,	,	PUNCT
admet-2214	847	10	zagreb	zagreb	PROPN
admet-2214	847	11	,	,	PUNCT
admet-2214	847	12	croatia	croatia	PROPN
admet-2214	847	13	.	.	PUNCT
admet-2214	848	1	this	this	DET
admet-2214	848	2	article	article	NOUN
admet-2214	848	3	is	be	AUX
admet-2214	848	4	an	an	DET
admet-2214	848	5	open	open	ADJ
admet-2214	848	6	-	-	PUNCT
admet-2214	848	7	access	access	NOUN
admet-2214	848	8	article	article	NOUN
admet-2214	848	9	distributed	distribute	VERB
admet-2214	848	10	under	under	ADP
admet-2214	848	11	the	the	DET
admet-2214	848	12	terms	term	NOUN
admet-2214	848	13	and	and	CCONJ
admet-2214	848	14	conditions	condition	NOUN
admet-2214	848	15	of	of	ADP
admet-2214	848	16	the	the	DET
admet-2214	848	17	creative	creative	ADJ
admet-2214	848	18	commons	common	NOUN
admet-2214	848	19	attribution	attribution	NOUN
admet-2214	848	20	license	license	NOUN
admet-2214	848	21	(	(	PUNCT
admet-2214	848	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2214	848	23	)	)	PUNCT
admet-2214	848	24	https://doi.org/10.5599/admet.2214	https://doi.org/10.5599/admet.2214	PROPN
admet-2214	848	25	https://doi.org/10.3109/02652048.2014.898707	https://doi.org/10.3109/02652048.2014.898707	PRON
admet-2214	848	26	https://doi.org/10.2217/nnm-2018-0120	https://doi.org/10.2217/nnm-2018-0120	ADJ
admet-2214	848	27	https://doi.org/10.1080/21691401.2018.1489822	https://doi.org/10.1080/21691401.2018.1489822	PROPN
admet-2214	848	28	https://doi.org/10.1016/j.jconrel.2012.03.020	https://doi.org/10.1016/j.jconrel.2012.03.020	VERB
admet-2214	848	29	https://doi.org/10.1016/j.addr.2020.07.016	https://doi.org/10.1016/j.addr.2020.07.016	PROPN
admet-2214	848	30	https://doi.org/10.1080/10428190500052438	https://doi.org/10.1080/10428190500052438	VERB
admet-2214	848	31	https://doi.org/10.2147/tcrm.s5688	https://doi.org/10.2147/tcrm.s5688	PROPN
admet-2214	848	32	https://doi.org/10.3109/09546634.2013.789474	https://doi.org/10.3109/09546634.2013.789474	PROPN
admet-2214	849	1	https://doi.org/10.1007/bf03259853	https://doi.org/10.1007/bf03259853	PROPN
admet-2214	849	2	https://doi.org/10.1007/s40265-020-01336-6	https://doi.org/10.1007/s40265-020-01336-6	PROPN
admet-2214	849	3	https://clinicaltrials.gov/search?cond=diffuse%20intrinsic%20pontine%20glioma	https://clinicaltrials.gov/search?cond=diffuse%20intrinsic%20pontine%20glioma	PROPN
admet-2214	849	4	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN