id	sid	tid	token	lemma	pos
admet-2268	1	1	berberine	berberine	PROPN
admet-2268	1	2	hcl	hcl	PROPN
admet-2268	1	3	and	and	CCONJ
admet-2268	1	4	diacerein	diacerein	ADV
admet-2268	1	5	loaded	load	VERB
admet-2268	1	6	dual	dual	ADJ
admet-2268	1	7	delivery	delivery	NOUN
admet-2268	1	8	transferosomes	transferosome	NOUN
admet-2268	1	9	:	:	PUNCT
admet-2268	1	10	formulation	formulation	NOUN
admet-2268	1	11	and	and	CCONJ
admet-2268	1	12	optimization	optimization	NOUN
admet-2268	1	13	using	use	VERB
admet-2268	1	14	box	box	NOUN
admet-2268	1	15	-	-	PUNCT
admet-2268	1	16	behnken	behnken	VERB
admet-2268	1	17	design	design	NOUN
admet-2268	1	18	doi	doi	NOUN
admet-2268	1	19	:	:	PUNCT
admet-2268	1	20	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	1	21	553	553	NUM
admet-2268	1	22	admet	admet	X
admet-2268	1	23	&	&	CCONJ
admet-2268	1	24	dmpk	dmpk	PROPN
admet-2268	1	25	12(3	12(3	PROPN
admet-2268	1	26	)	)	PUNCT
admet-2268	1	27	(	(	PUNCT
admet-2268	1	28	2024	2024	NUM
admet-2268	1	29	)	)	PUNCT
admet-2268	1	30	553	553	NUM
admet-2268	1	31	-	-	SYM
admet-2268	1	32	580	580	NUM
admet-2268	1	33	;	;	PUNCT
admet-2268	1	34	doi	doi	NOUN
admet-2268	1	35	:	:	PUNCT
admet-2268	1	36	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	1	37	open	open	ADJ
admet-2268	1	38	access	access	NOUN
admet-2268	1	39	:	:	PUNCT
admet-2268	1	40	issn	issn	PROPN
admet-2268	1	41	:	:	PUNCT
admet-2268	1	42	1848	1848	NUM
admet-2268	1	43	-	-	SYM
admet-2268	1	44	7718	7718	NUM
admet-2268	1	45	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2268	1	46	original	original	ADJ
admet-2268	1	47	scientific	scientific	ADJ
admet-2268	1	48	paper	paper	NOUN
admet-2268	1	49	berberine	berberine	NOUN
admet-2268	1	50	hcl	hcl	PROPN
admet-2268	1	51	and	and	CCONJ
admet-2268	1	52	diacerein	diacerein	ADV
admet-2268	1	53	loaded	load	VERB
admet-2268	1	54	dual	dual	ADJ
admet-2268	1	55	delivery	delivery	NOUN
admet-2268	1	56	transferosomes	transferosome	NOUN
admet-2268	1	57	:	:	PUNCT
admet-2268	1	58	formulation	formulation	NOUN
admet-2268	1	59	and	and	CCONJ
admet-2268	1	60	optimization	optimization	NOUN
admet-2268	1	61	using	use	VERB
admet-2268	1	62	box	box	NOUN
admet-2268	1	63	-	-	PUNCT
admet-2268	1	64	behnken	behnken	VERB
admet-2268	1	65	design	design	NOUN
admet-2268	1	66	siddharth	siddharth	PROPN
admet-2268	1	67	singh	singh	PROPN
admet-2268	1	68	and	and	CCONJ
admet-2268	1	69	rajendra	rajendra	PROPN
admet-2268	1	70	awasthi	awasthi	PROPN
admet-2268	1	71	*	*	PROPN
admet-2268	1	72	department	department	PROPN
admet-2268	1	73	of	of	ADP
admet-2268	1	74	pharmaceutical	pharmaceutical	NOUN
admet-2268	1	75	sciences	science	NOUN
admet-2268	1	76	,	,	PUNCT
admet-2268	1	77	school	school	NOUN
admet-2268	1	78	of	of	ADP
admet-2268	1	79	health	health	PROPN
admet-2268	1	80	sciences	sciences	PROPN
admet-2268	1	81	&	&	CCONJ
admet-2268	1	82	technology	technology	NOUN
admet-2268	1	83	,	,	PUNCT
admet-2268	1	84	upes	upe	NOUN
admet-2268	1	85	,	,	PUNCT
admet-2268	1	86	dehradun	dehradun	PROPN
admet-2268	1	87	,	,	PUNCT
admet-2268	1	88	uttarakhand	uttarakhand	PROPN
admet-2268	1	89	,	,	PUNCT
admet-2268	1	90	india	india	PROPN
admet-2268	1	91	*	*	PUNCT
admet-2268	1	92	corresponding	correspond	VERB
admet-2268	1	93	author	author	NOUN
admet-2268	1	94	:	:	PUNCT
admet-2268	1	95	e	e	NOUN
admet-2268	1	96	-	-	NOUN
admet-2268	1	97	mail	mail	NOUN
admet-2268	1	98	:	:	PUNCT
admet-2268	1	99	awasthi02@gmail.com	awasthi02@gmail.com	PROPN
admet-2268	1	100	,	,	PUNCT
admet-2268	1	101	rajendra.awasthi@ddn.upes.ac.in	rajendra.awasthi@ddn.upes.ac.in	NUM
admet-2268	1	102	;	;	PUNCT
admet-2268	1	103	tel	tel	PROPN
admet-2268	1	104	.	.	PUNCT
admet-2268	1	105	:	:	PUNCT
admet-2268	2	1	+91	+91	PROPN
admet-2268	2	2	-	-	SYM
admet-2268	2	3	9459234530	9459234530	NUM
admet-2268	2	4	received	receive	VERB
admet-2268	2	5	:	:	PUNCT
admet-2268	2	6	february	february	PROPN
admet-2268	2	7	1	1	NUM
admet-2268	2	8	,	,	PUNCT
admet-2268	2	9	2024	2024	NUM
admet-2268	2	10	;	;	PUNCT
admet-2268	2	11	revised	revise	VERB
admet-2268	2	12	:	:	PUNCT
admet-2268	2	13	april	april	PROPN
admet-2268	2	14	21	21	NUM
admet-2268	2	15	,	,	PUNCT
admet-2268	2	16	2024	2024	NUM
admet-2268	2	17	;	;	PUNCT
admet-2268	2	18	published	publish	VERB
admet-2268	2	19	:	:	PUNCT
admet-2268	2	20	april	april	PROPN
admet-2268	2	21	29,2024	29,2024	NUM
admet-2268	3	1	abstract	abstract	ADJ
admet-2268	3	2	introduction	introduction	NOUN
admet-2268	3	3	:	:	PUNCT
admet-2268	3	4	berberine	berberine	NOUN
admet-2268	3	5	is	be	AUX
admet-2268	3	6	a	a	DET
admet-2268	3	7	poorly	poorly	ADV
admet-2268	3	8	water	water	NOUN
admet-2268	3	9	-	-	PUNCT
admet-2268	3	10	soluble	soluble	ADJ
admet-2268	3	11	alkaloid	alkaloid	NOUN
admet-2268	3	12	compound	compound	NOUN
admet-2268	3	13	showing	show	VERB
admet-2268	3	14	significant	significant	ADJ
admet-2268	3	15	anti	anti	ADJ
admet-2268	3	16	-	-	ADJ
admet-2268	3	17	inflammatory	inflammatory	ADJ
admet-2268	3	18	characteristics	characteristic	NOUN
admet-2268	3	19	.	.	PUNCT
admet-2268	4	1	it	it	PRON
admet-2268	4	2	reduces	reduce	VERB
admet-2268	4	3	the	the	DET
admet-2268	4	4	levels	level	NOUN
admet-2268	4	5	of	of	ADP
admet-2268	4	6	pro	pro	ADJ
admet-2268	4	7	-	-	ADJ
admet-2268	4	8	inflammatory	inflammatory	ADJ
admet-2268	4	9	and	and	CCONJ
admet-2268	4	10	inflammatory	inflammatory	ADJ
admet-2268	4	11	cytokines	cytokine	NOUN
admet-2268	4	12	,	,	PUNCT
admet-2268	4	13	including	include	VERB
admet-2268	4	14	tumour	tumour	NOUN
admet-2268	4	15	necrosis	necrosis	NOUN
admet-2268	4	16	factor	factor	NOUN
admet-2268	4	17	(	(	PUNCT
admet-2268	4	18	tnf-𝛼	tnf-𝛼	ADJ
admet-2268	4	19	,	,	PUNCT
admet-2268	4	20	ifn-𝛾	ifn-𝛾	NUM
admet-2268	4	21	)	)	PUNCT
admet-2268	4	22	and	and	CCONJ
admet-2268	4	23	interleukin	interleukin	NOUN
admet-2268	4	24	(	(	PUNCT
admet-2268	4	25	il-23	il-23	NOUN
admet-2268	4	26	,	,	PUNCT
admet-2268	4	27	il-12	il-12	NOUN
admet-2268	4	28	,	,	PUNCT
admet-2268	4	29	and	and	CCONJ
admet-2268	4	30	il-23	il-23	NOUN
admet-2268	4	31	)	)	PUNCT
admet-2268	4	32	.	.	PUNCT
admet-2268	5	1	diacerein	diacerein	PROPN
admet-2268	5	2	significantly	significantly	ADV
admet-2268	5	3	reduces	reduce	VERB
admet-2268	5	4	the	the	DET
admet-2268	5	5	splenomegaly	splenomegaly	NOUN
admet-2268	5	6	associated	associate	VERB
admet-2268	5	7	with	with	ADP
admet-2268	5	8	psoriasis	psoriasis	NOUN
admet-2268	5	9	.	.	PUNCT
admet-2268	6	1	it	it	PRON
admet-2268	6	2	downregulates	downregulate	VERB
admet-2268	6	3	the	the	DET
admet-2268	6	4	production	production	NOUN
admet-2268	6	5	of	of	ADP
admet-2268	6	6	tnf	tnf	PROPN
admet-2268	6	7	-	-	PUNCT
admet-2268	6	8	α	α	PROPN
admet-2268	6	9	and	and	CCONJ
admet-2268	6	10	il-12	il-12	NOUN
admet-2268	6	11	.	.	PUNCT
admet-2268	6	12	method	method	PROPN
admet-2268	6	13	:	:	PUNCT
admet-2268	6	14	this	this	DET
admet-2268	6	15	study	study	NOUN
admet-2268	6	16	reported	report	VERB
admet-2268	6	17	the	the	DET
admet-2268	6	18	development	development	NOUN
admet-2268	6	19	of	of	ADP
admet-2268	6	20	transferosomes	transferosome	NOUN
admet-2268	6	21	containing	contain	VERB
admet-2268	6	22	berberine	berberine	NOUN
admet-2268	6	23	hcl	hcl	PROPN
admet-2268	6	24	and	and	CCONJ
admet-2268	6	25	diacerein	diacerein	ADV
admet-2268	6	26	using	use	VERB
admet-2268	6	27	a	a	DET
admet-2268	6	28	film	film	NOUN
admet-2268	6	29	hydration	hydration	NOUN
admet-2268	6	30	method	method	NOUN
admet-2268	6	31	followed	follow	VERB
admet-2268	6	32	by	by	ADP
admet-2268	6	33	optimization	optimization	NOUN
admet-2268	6	34	using	use	VERB
admet-2268	6	35	a	a	DET
admet-2268	6	36	box	box	NOUN
admet-2268	6	37	-	-	PUNCT
admet-2268	6	38	behnken	behnken	VERB
admet-2268	6	39	design	design	NOUN
admet-2268	6	40	.	.	PUNCT
admet-2268	7	1	sodium	sodium	NOUN
admet-2268	7	2	deoxycholate	deoxycholate	PROPN
admet-2268	7	3	was	be	AUX
admet-2268	7	4	used	use	VERB
admet-2268	7	5	as	as	ADP
admet-2268	7	6	an	an	DET
admet-2268	7	7	edge	edge	NOUN
admet-2268	7	8	activator	activator	NOUN
admet-2268	7	9	.	.	PUNCT
admet-2268	8	1	the	the	DET
admet-2268	8	2	impact	impact	NOUN
admet-2268	8	3	of	of	ADP
admet-2268	8	4	independent	independent	ADJ
admet-2268	8	5	variables	variable	NOUN
admet-2268	8	6	(	(	PUNCT
admet-2268	8	7	amount	amount	NOUN
admet-2268	8	8	of	of	ADP
admet-2268	8	9	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	8	10	,	,	PUNCT
admet-2268	8	11	amount	amount	NOUN
admet-2268	8	12	of	of	ADP
admet-2268	8	13	edge	edge	NOUN
admet-2268	8	14	activator	activator	NOUN
admet-2268	8	15	,	,	PUNCT
admet-2268	8	16	and	and	CCONJ
admet-2268	8	17	sonication	sonication	NOUN
admet-2268	8	18	cycles	cycle	NOUN
admet-2268	8	19	)	)	PUNCT
admet-2268	8	20	on	on	ADP
admet-2268	8	21	dependent	dependent	ADJ
admet-2268	8	22	variables	variable	NOUN
admet-2268	8	23	(	(	PUNCT
admet-2268	8	24	particle	particle	NOUN
admet-2268	8	25	size	size	NOUN
admet-2268	8	26	and	and	CCONJ
admet-2268	8	27	entrapment	entrapment	ADJ
admet-2268	8	28	efficiency	efficiency	NOUN
admet-2268	8	29	)	)	PUNCT
admet-2268	8	30	was	be	AUX
admet-2268	8	31	examined	examine	VERB
admet-2268	8	32	.	.	PUNCT
admet-2268	9	1	the	the	DET
admet-2268	9	2	optimized	optimize	VERB
admet-2268	9	3	formulation	formulation	NOUN
admet-2268	9	4	was	be	AUX
admet-2268	9	5	characterized	characterize	VERB
admet-2268	9	6	for	for	ADP
admet-2268	9	7	polydispersity	polydispersity	NOUN
admet-2268	9	8	index	index	NOUN
admet-2268	9	9	,	,	PUNCT
admet-2268	9	10	vesicle	vesicle	NOUN
admet-2268	9	11	size	size	NOUN
admet-2268	9	12	,	,	PUNCT
admet-2268	9	13	entrapment	entrapment	ADJ
admet-2268	9	14	efficiency	efficiency	NOUN
admet-2268	9	15	,	,	PUNCT
admet-2268	9	16	ζ	ζ	NOUN
admet-2268	9	17	potential	potential	NOUN
admet-2268	9	18	,	,	PUNCT
admet-2268	9	19	spectral	spectral	ADJ
admet-2268	9	20	analysis	analysis	NOUN
admet-2268	9	21	like	like	ADP
admet-2268	9	22	fourier	fourier	NOUN
admet-2268	9	23	transform	transform	NOUN
admet-2268	9	24	infrared	infrare	VERB
admet-2268	9	25	,	,	PUNCT
admet-2268	9	26	thermal	thermal	ADJ
admet-2268	9	27	analysis	analysis	NOUN
admet-2268	9	28	,	,	PUNCT
admet-2268	9	29	x	x	NOUN
admet-2268	9	30	-	-	NOUN
admet-2268	9	31	ray	ray	NOUN
admet-2268	9	32	diffraction	diffraction	NOUN
admet-2268	9	33	,	,	PUNCT
admet-2268	9	34	deformability	deformability	NOUN
admet-2268	9	35	,	,	PUNCT
admet-2268	9	36	transmission	transmission	NOUN
admet-2268	9	37	electron	electron	NOUN
admet-2268	9	38	microscopy	microscopy	NOUN
admet-2268	9	39	,	,	PUNCT
admet-2268	9	40	antioxidant	antioxidant	ADJ
admet-2268	9	41	assay	assay	NOUN
admet-2268	9	42	,	,	PUNCT
admet-2268	9	43	in	in	ADP
admet-2268	9	44	-	-	PUNCT
admet-2268	9	45	vitro	vitro	X
admet-2268	9	46	release	release	NOUN
admet-2268	9	47	,	,	PUNCT
admet-2268	9	48	and	and	CCONJ
admet-2268	9	49	ex	ex	ADJ
admet-2268	9	50	-	-	ADJ
admet-2268	9	51	vivo	vivo	ADJ
admet-2268	9	52	skin	skin	NOUN
admet-2268	9	53	permeation	permeation	NOUN
admet-2268	9	54	studies	study	NOUN
admet-2268	9	55	.	.	PUNCT
admet-2268	10	1	results	result	NOUN
admet-2268	10	2	:	:	PUNCT
admet-2268	10	3	the	the	DET
admet-2268	10	4	optimized	optimize	VERB
admet-2268	10	5	formulation	formulation	NOUN
admet-2268	10	6	had	have	VERB
admet-2268	10	7	a	a	DET
admet-2268	10	8	particle	particle	NOUN
admet-2268	10	9	size	size	NOUN
admet-2268	10	10	of	of	ADP
admet-2268	10	11	110.90±2.8	110.90±2.8	NUM
admet-2268	10	12	nm	nm	NOUN
admet-2268	10	13	with	with	ADP
admet-2268	10	14	high	high	ADJ
admet-2268	10	15	entrapment	entrapment	ADJ
admet-2268	10	16	efficiency	efficiency	NOUN
admet-2268	10	17	(	(	PUNCT
admet-2268	10	18	89.50±1.5	89.50±1.5	PROPN
admet-2268	10	19	of	of	ADP
admet-2268	10	20	berberine	berberine	PROPN
admet-2268	10	21	hcl	hcl	PROPN
admet-2268	10	22	and	and	CCONJ
admet-2268	10	23	91.23±1.8	91.23±1.8	NUM
admet-2268	10	24	of	of	ADP
admet-2268	10	25	diacerein	diacerein	ADJ
admet-2268	10	26	)	)	PUNCT
admet-2268	10	27	.	.	PUNCT
admet-2268	11	1	deformability	deformability	PROPN
admet-2268	11	2	,	,	PUNCT
admet-2268	11	3	polydispersity	polydispersity	NOUN
admet-2268	11	4	index	index	NOUN
admet-2268	11	5	,	,	PUNCT
admet-2268	11	6	ζ	ζ	NOUN
admet-2268	11	7	potential	potential	NOUN
admet-2268	11	8	,	,	PUNCT
admet-2268	11	9	and	and	CCONJ
admet-2268	11	10	antioxidant	antioxidant	ADJ
admet-2268	11	11	activity	activity	NOUN
admet-2268	11	12	of	of	ADP
admet-2268	11	13	the	the	DET
admet-2268	11	14	optimized	optimize	VERB
admet-2268	11	15	formulation	formulation	NOUN
admet-2268	11	16	were	be	AUX
admet-2268	11	17	2.44	2.44	NUM
admet-2268	11	18	,	,	PUNCT
admet-2268	11	19	0.296	0.296	NUM
admet-2268	11	20	,	,	PUNCT
admet-2268	11	21	-13.3	-13.3	ADJ
admet-2268	11	22	,	,	PUNCT
admet-2268	11	23	and	and	CCONJ
admet-2268	11	24	38.36	38.36	NUM
admet-2268	11	25	%	%	NOUN
admet-2268	11	26	,	,	PUNCT
admet-2268	11	27	respectively	respectively	ADV
admet-2268	11	28	.	.	PUNCT
admet-2268	12	1	optimized	optimize	VERB
admet-2268	12	2	transferosomes	transferosomes	PROPN
admet-2268	12	3	exhibited	exhibit	VERB
admet-2268	12	4	82.093±0.81	82.093±0.81	NUM
admet-2268	12	5	%	%	NOUN
admet-2268	12	6	and	and	CCONJ
admet-2268	12	7	85.02±3.81	85.02±3.81	NUM
admet-2268	12	8	%	%	NOUN
admet-2268	12	9	release	release	NOUN
admet-2268	12	10	of	of	ADP
admet-2268	12	11	berberine	berberine	NOUN
admet-2268	12	12	hcl	hcl	PROPN
admet-2268	12	13	and	and	CCONJ
admet-2268	12	14	diacerein	diacerein	ADV
admet-2268	12	15	after	after	ADP
admet-2268	12	16	24	24	NUM
admet-2268	12	17	h	h	NOUN
admet-2268	12	18	of	of	ADP
admet-2268	12	19	dissolution	dissolution	NOUN
admet-2268	12	20	study	study	NOUN
admet-2268	12	21	.	.	PUNCT
admet-2268	13	1	the	the	DET
admet-2268	13	2	transdermal	transdermal	ADJ
admet-2268	13	3	flux	flux	NOUN
admet-2268	13	4	of	of	ADP
admet-2268	13	5	optimized	optimize	VERB
admet-2268	13	6	formulation	formulation	NOUN
admet-2268	13	7	was	be	AUX
admet-2268	13	8	0.0224	0.0224	NUM
admet-2268	13	9	µg	µg	ADV
admet-2268	13	10	cm-2	cm-2	NOUN
admet-2268	13	11	h-1	h-1	X
admet-2268	13	12	(	(	PUNCT
admet-2268	13	13	2.24	2.24	NUM
admet-2268	13	14	cm	cm	NOUN
admet-2268	13	15	h-1	h-1	NOUN
admet-2268	13	16	permeation	permeation	NOUN
admet-2268	13	17	coefficient	coefficient	NOUN
admet-2268	13	18	)	)	PUNCT
admet-2268	13	19	and	and	CCONJ
admet-2268	13	20	0.0462	0.0462	NUM
admet-2268	13	21	µg	µg	ADV
admet-2268	13	22	cm-2	cm-2	NOUN
admet-2268	13	23	h-1	h-1	X
admet-2268	13	24	(	(	PUNCT
admet-2268	13	25	4.62	4.62	NUM
admet-2268	13	26	cm	cm	NOUN
admet-2268	13	27	h-1	h-1	NOUN
admet-2268	13	28	permeation	permeation	NOUN
admet-2268	13	29	coefficient	coefficient	NOUN
admet-2268	13	30	)	)	PUNCT
admet-2268	13	31	,	,	PUNCT
admet-2268	13	32	respectively	respectively	ADV
admet-2268	13	33	,	,	PUNCT
admet-2268	13	34	for	for	ADP
admet-2268	13	35	berberine	berberine	NOUN
admet-2268	13	36	hcl	hcl	PROPN
admet-2268	13	37	and	and	CCONJ
admet-2268	13	38	diacerein	diacerein	ADJ
admet-2268	13	39	.	.	PUNCT
admet-2268	14	1	raman	raman	VERB
admet-2268	14	2	analysis	analysis	NOUN
admet-2268	14	3	of	of	ADP
admet-2268	14	4	treated	treat	VERB
admet-2268	14	5	pig	pig	NOUN
admet-2268	14	6	skin	skin	NOUN
admet-2268	14	7	confirmed	confirm	VERB
admet-2268	14	8	that	that	SCONJ
admet-2268	14	9	the	the	DET
admet-2268	14	10	transferosomes	transferosome	NOUN
admet-2268	14	11	can	can	AUX
admet-2268	14	12	permeate	permeate	VERB
admet-2268	14	13	the	the	DET
admet-2268	14	14	skin	skin	NOUN
admet-2268	14	15	.	.	PUNCT
admet-2268	15	1	no	no	DET
admet-2268	15	2	change	change	NOUN
admet-2268	15	3	in	in	ADP
admet-2268	15	4	the	the	DET
admet-2268	15	5	skin	skin	NOUN
admet-2268	15	6	condition	condition	NOUN
admet-2268	15	7	or	or	CCONJ
admet-2268	15	8	irritation	irritation	NOUN
admet-2268	15	9	was	be	AUX
admet-2268	15	10	observed	observe	VERB
admet-2268	15	11	in	in	ADP
admet-2268	15	12	balb	balb	ADJ
admet-2268	15	13	/	/	SYM
admet-2268	15	14	c	c	NOUN
admet-2268	15	15	mice	mouse	NOUN
admet-2268	15	16	.	.	PUNCT
admet-2268	16	1	formulation	formulation	NOUN
admet-2268	16	2	stored	store	VERB
admet-2268	16	3	at	at	ADP
admet-2268	16	4	4	4	NUM
admet-2268	16	5	and	and	CCONJ
admet-2268	16	6	25±2	25±2	NUM
admet-2268	16	7	°	°	ADP
admet-2268	16	8	c	c	NOUN
admet-2268	16	9	/	/	SYM
admet-2268	16	10	60±5	60±5	NOUN
admet-2268	16	11	%	%	NOUN
admet-2268	16	12	relative	relative	ADJ
admet-2268	16	13	humidity	humidity	NOUN
admet-2268	16	14	was	be	AUX
admet-2268	16	15	stable	stable	ADJ
admet-2268	16	16	for	for	ADP
admet-2268	16	17	3	3	NUM
admet-2268	16	18	months	month	NOUN
admet-2268	16	19	.	.	PUNCT
admet-2268	17	1	conclusions	conclusion	NOUN
admet-2268	17	2	:	:	PUNCT
admet-2268	17	3	thus	thus	ADV
admet-2268	17	4	,	,	PUNCT
admet-2268	17	5	the	the	DET
admet-2268	17	6	results	result	NOUN
admet-2268	17	7	demonstrated	demonstrate	VERB
admet-2268	17	8	successful	successful	ADJ
admet-2268	17	9	optimization	optimization	NOUN
admet-2268	17	10	of	of	ADP
admet-2268	17	11	the	the	DET
admet-2268	17	12	transferosomes	transferosome	NOUN
admet-2268	17	13	for	for	ADP
admet-2268	17	14	the	the	DET
admet-2268	17	15	efficient	efficient	ADJ
admet-2268	17	16	topical	topical	ADJ
admet-2268	17	17	delivery	delivery	NOUN
admet-2268	17	18	of	of	ADP
admet-2268	17	19	berberine	berberine	NOUN
admet-2268	17	20	hcl	hcl	PROPN
admet-2268	17	21	and	and	CCONJ
admet-2268	17	22	diacerein	diacerein	ADJ
admet-2268	17	23	in	in	ADP
admet-2268	17	24	the	the	DET
admet-2268	17	25	effective	effective	ADJ
admet-2268	17	26	management	management	NOUN
admet-2268	17	27	of	of	ADP
admet-2268	17	28	psoriasis	psoriasis	NOUN
admet-2268	17	29	.	.	PUNCT
admet-2268	18	1	©	©	ADP
admet-2268	18	2	2024	2024	NUM
admet-2268	18	3	by	by	ADP
admet-2268	18	4	the	the	DET
admet-2268	18	5	authors	author	NOUN
admet-2268	18	6	.	.	PUNCT
admet-2268	19	1	this	this	DET
admet-2268	19	2	article	article	NOUN
admet-2268	19	3	is	be	AUX
admet-2268	19	4	an	an	DET
admet-2268	19	5	open	open	ADJ
admet-2268	19	6	-	-	PUNCT
admet-2268	19	7	access	access	NOUN
admet-2268	19	8	article	article	NOUN
admet-2268	19	9	distributed	distribute	VERB
admet-2268	19	10	under	under	ADP
admet-2268	19	11	the	the	DET
admet-2268	19	12	terms	term	NOUN
admet-2268	19	13	and	and	CCONJ
admet-2268	19	14	conditions	condition	NOUN
admet-2268	19	15	of	of	ADP
admet-2268	19	16	the	the	DET
admet-2268	19	17	creative	creative	ADJ
admet-2268	19	18	commons	common	NOUN
admet-2268	19	19	attribution	attribution	NOUN
admet-2268	19	20	license	license	NOUN
admet-2268	19	21	(	(	PUNCT
admet-2268	19	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2268	19	23	)	)	PUNCT
admet-2268	19	24	.	.	PUNCT
admet-2268	20	1	keywords	keyword	NOUN
admet-2268	20	2	inflammatory	inflammatory	ADJ
admet-2268	20	3	cytokines	cytokine	NOUN
admet-2268	20	4	,	,	PUNCT
admet-2268	20	5	pro	pro	ADJ
admet-2268	20	6	-	-	ADJ
admet-2268	20	7	inflammatory	inflammatory	ADJ
admet-2268	20	8	,	,	PUNCT
admet-2268	20	9	tumour	tumour	ADJ
admet-2268	20	10	necrosis	necrosis	NOUN
admet-2268	20	11	factor	factor	NOUN
admet-2268	20	12	,	,	PUNCT
admet-2268	20	13	psoriasis	psoriasis	NOUN
admet-2268	20	14	,	,	PUNCT
admet-2268	20	15	ultraflexible	ultraflexible	ADJ
admet-2268	20	16	vesicles	vesicle	NOUN
admet-2268	20	17	introduction	introduction	NOUN
admet-2268	20	18	psoriasis	psoriasis	NOUN
admet-2268	20	19	is	be	AUX
admet-2268	20	20	a	a	DET
admet-2268	20	21	chronic	chronic	ADJ
admet-2268	20	22	autoimmune	autoimmune	ADJ
admet-2268	20	23	condition	condition	NOUN
admet-2268	20	24	that	that	PRON
admet-2268	20	25	affects	affect	VERB
admet-2268	20	26	an	an	DET
admet-2268	20	27	estimated	estimate	VERB
admet-2268	20	28	1	1	NUM
admet-2268	20	29	to	to	PART
admet-2268	20	30	3	3	NUM
admet-2268	20	31	%	%	NOUN
admet-2268	20	32	of	of	ADP
admet-2268	20	33	the	the	DET
admet-2268	20	34	worldwide	worldwide	ADJ
admet-2268	20	35	population	population	NOUN
admet-2268	20	36	.	.	PUNCT
admet-2268	21	1	it	it	PRON
admet-2268	21	2	is	be	AUX
admet-2268	21	3	characterized	characterize	VERB
admet-2268	21	4	by	by	ADP
admet-2268	21	5	an	an	DET
admet-2268	21	6	anomalous	anomalous	ADJ
admet-2268	21	7	proliferation	proliferation	NOUN
admet-2268	21	8	of	of	ADP
admet-2268	21	9	keratinocytes	keratinocyte	NOUN
admet-2268	21	10	,	,	PUNCT
admet-2268	21	11	followed	follow	VERB
admet-2268	21	12	by	by	ADP
admet-2268	21	13	an	an	DET
admet-2268	21	14	infiltration	infiltration	NOUN
admet-2268	21	15	of	of	ADP
admet-2268	21	16	cells	cell	NOUN
admet-2268	21	17	associated	associate	VERB
admet-2268	21	18	with	with	ADP
admet-2268	21	19	inflammation	inflammation	NOUN
admet-2268	21	20	.	.	PUNCT
admet-2268	22	1	the	the	DET
admet-2268	22	2	average	average	ADJ
admet-2268	22	3	duration	duration	NOUN
admet-2268	22	4	of	of	ADP
admet-2268	22	5	the	the	DET
admet-2268	22	6	maturation	maturation	NOUN
admet-2268	22	7	process	process	NOUN
admet-2268	22	8	of	of	ADP
admet-2268	22	9	keratinocytes	keratinocyte	NOUN
admet-2268	22	10	in	in	ADP
admet-2268	22	11	healthy	healthy	ADJ
admet-2268	22	12	skin	skin	NOUN
admet-2268	22	13	is	be	AUX
admet-2268	22	14	about	about	ADV
admet-2268	22	15	30	30	NUM
admet-2268	22	16	days	day	NOUN
admet-2268	22	17	.	.	PUNCT
admet-2268	23	1	however	however	ADV
admet-2268	23	2	,	,	PUNCT
admet-2268	23	3	people	people	NOUN
admet-2268	23	4	with	with	ADP
admet-2268	23	5	psoriasis	psoriasis	NOUN
admet-2268	23	6	have	have	VERB
admet-2268	23	7	an	an	DET
admet-2268	23	8	accelerated	accelerated	ADJ
admet-2268	23	9	process	process	NOUN
admet-2268	23	10	,	,	PUNCT
admet-2268	23	11	completing	complete	VERB
admet-2268	23	12	it	it	PRON
admet-2268	23	13	within	within	ADP
admet-2268	23	14	a	a	DET
admet-2268	23	15	substantially	substantially	ADV
admet-2268	23	16	shorter	short	ADJ
admet-2268	23	17	timeframe	timeframe	NOUN
admet-2268	23	18	of	of	ADP
admet-2268	23	19	5	5	NUM
admet-2268	23	20	-	-	SYM
admet-2268	23	21	7	7	NUM
admet-2268	23	22	days	day	NOUN
admet-2268	23	23	[	[	X
admet-2268	23	24	1,2	1,2	NUM
admet-2268	23	25	]	]	PUNCT
admet-2268	23	26	.	.	PUNCT
admet-2268	24	1	psoriasis	psoriasis	NOUN
admet-2268	24	2	is	be	AUX
admet-2268	24	3	subject	subject	ADJ
admet-2268	24	4	to	to	ADP
admet-2268	24	5	multiple	multiple	ADJ
admet-2268	24	6	etiological	etiological	ADJ
admet-2268	24	7	factors	factor	NOUN
admet-2268	24	8	,	,	PUNCT
admet-2268	24	9	including	include	VERB
admet-2268	24	10	,	,	PUNCT
admet-2268	24	11	but	but	CCONJ
admet-2268	24	12	not	not	PART
admet-2268	24	13	limited	limit	VERB
admet-2268	24	14	to	to	ADP
admet-2268	24	15	,	,	PUNCT
admet-2268	24	16	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	24	17	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	24	18	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2268	24	19	mailto:awasthi02@gmail.com	mailto:awasthi02@gmail.com	PROPN
admet-2268	24	20	mailto:rajendra.awasthi@ddn.upes.ac.in	mailto:rajendra.awasthi@ddn.upes.ac.in	PROPN
admet-2268	24	21	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2268	24	22	s.	s.	PROPN
admet-2268	24	23	singh	singh	PROPN
admet-2268	24	24	and	and	CCONJ
admet-2268	24	25	r.	r.	PROPN
admet-2268	24	26	awasthi	awasthi	PROPN
admet-2268	24	27	admet	admet	PROPN
admet-2268	24	28	&	&	CCONJ
admet-2268	24	29	dmpk	dmpk	PROPN
admet-2268	24	30	12(3	12(3	PROPN
admet-2268	24	31	)	)	PUNCT
admet-2268	24	32	(	(	PUNCT
admet-2268	24	33	2024	2024	NUM
admet-2268	24	34	)	)	PUNCT
admet-2268	24	35	553	553	NUM
admet-2268	24	36	-	-	SYM
admet-2268	24	37	580	580	NUM
admet-2268	24	38	554	554	NUM
admet-2268	24	39	trauma	trauma	NOUN
admet-2268	24	40	,	,	PUNCT
admet-2268	24	41	stress	stress	NOUN
admet-2268	24	42	,	,	PUNCT
admet-2268	24	43	hereditary	hereditary	ADJ
admet-2268	24	44	genetic	genetic	ADJ
admet-2268	24	45	predisposition	predisposition	NOUN
admet-2268	24	46	,	,	PUNCT
admet-2268	24	47	and	and	CCONJ
admet-2268	24	48	other	other	ADJ
admet-2268	24	49	determinants	determinant	NOUN
admet-2268	24	50	that	that	PRON
admet-2268	24	51	exert	exert	VERB
admet-2268	24	52	an	an	DET
admet-2268	24	53	influence	influence	NOUN
admet-2268	24	54	on	on	ADP
admet-2268	24	55	the	the	DET
admet-2268	24	56	physiological	physiological	ADJ
admet-2268	24	57	functioning	functioning	NOUN
admet-2268	24	58	of	of	ADP
admet-2268	24	59	keratinocytes	keratinocyte	NOUN
admet-2268	24	60	.	.	PUNCT
admet-2268	25	1	the	the	DET
admet-2268	25	2	appearance	appearance	NOUN
admet-2268	25	3	of	of	ADP
admet-2268	25	4	white	white	ADJ
admet-2268	25	5	scaly	scaly	NOUN
admet-2268	25	6	plaques	plaque	NOUN
admet-2268	25	7	,	,	PUNCT
admet-2268	25	8	accompanied	accompany	VERB
admet-2268	25	9	by	by	ADP
admet-2268	25	10	itching	itching	NOUN
admet-2268	25	11	and	and	CCONJ
admet-2268	25	12	pain	pain	NOUN
admet-2268	25	13	,	,	PUNCT
admet-2268	25	14	has	have	VERB
admet-2268	25	15	the	the	DET
admet-2268	25	16	potential	potential	NOUN
admet-2268	25	17	to	to	PART
admet-2268	25	18	greatly	greatly	ADV
admet-2268	25	19	intensify	intensify	VERB
admet-2268	25	20	patient	patient	ADJ
admet-2268	25	21	distress	distress	NOUN
admet-2268	25	22	and	and	CCONJ
admet-2268	25	23	perhaps	perhaps	ADV
admet-2268	25	24	result	result	VERB
admet-2268	25	25	in	in	ADP
admet-2268	25	26	the	the	DET
admet-2268	25	27	development	development	NOUN
admet-2268	25	28	of	of	ADP
admet-2268	25	29	serious	serious	ADJ
admet-2268	25	30	cutaneous	cutaneous	ADJ
admet-2268	25	31	diseases	disease	NOUN
admet-2268	25	32	[	[	X
admet-2268	25	33	3	3	NUM
admet-2268	25	34	]	]	PUNCT
admet-2268	25	35	.	.	PUNCT
admet-2268	26	1	in	in	ADP
admet-2268	26	2	addition	addition	NOUN
admet-2268	26	3	to	to	ADP
admet-2268	26	4	cutaneous	cutaneous	ADJ
admet-2268	26	5	morphological	morphological	ADJ
admet-2268	26	6	concerns	concern	NOUN
admet-2268	26	7	,	,	PUNCT
admet-2268	26	8	individuals	individual	NOUN
admet-2268	26	9	diagnosed	diagnose	VERB
admet-2268	26	10	with	with	ADP
admet-2268	26	11	psoriasis	psoriasis	NOUN
admet-2268	26	12	also	also	ADV
admet-2268	26	13	have	have	VERB
admet-2268	26	14	comorbidities	comorbiditie	NOUN
admet-2268	26	15	such	such	ADJ
admet-2268	26	16	as	as	ADP
admet-2268	26	17	depression	depression	NOUN
admet-2268	26	18	and	and	CCONJ
admet-2268	26	19	anxiety	anxiety	NOUN
admet-2268	26	20	,	,	PUNCT
admet-2268	26	21	which	which	PRON
admet-2268	26	22	can	can	AUX
admet-2268	26	23	contribute	contribute	VERB
admet-2268	26	24	to	to	ADP
admet-2268	26	25	the	the	DET
admet-2268	26	26	development	development	NOUN
admet-2268	26	27	of	of	ADP
admet-2268	26	28	suicidal	suicidal	ADJ
admet-2268	26	29	ideas	idea	NOUN
admet-2268	26	30	and	and	CCONJ
admet-2268	26	31	behaviours	behaviour	NOUN
admet-2268	26	32	.	.	PUNCT
admet-2268	27	1	a	a	DET
admet-2268	27	2	variety	variety	NOUN
admet-2268	27	3	of	of	ADP
admet-2268	27	4	therapeutic	therapeutic	ADJ
admet-2268	27	5	interventions	intervention	NOUN
admet-2268	27	6	are	be	AUX
admet-2268	27	7	available	available	ADJ
admet-2268	27	8	for	for	ADP
admet-2268	27	9	the	the	DET
admet-2268	27	10	management	management	NOUN
admet-2268	27	11	of	of	ADP
admet-2268	27	12	psoriasis	psoriasis	NOUN
admet-2268	27	13	.	.	PUNCT
admet-2268	28	1	however	however	ADV
admet-2268	28	2	,	,	PUNCT
admet-2268	28	3	it	it	PRON
admet-2268	28	4	is	be	AUX
admet-2268	28	5	crucial	crucial	ADJ
admet-2268	28	6	to	to	PART
admet-2268	28	7	note	note	VERB
admet-2268	28	8	that	that	SCONJ
admet-2268	28	9	they	they	PRON
admet-2268	28	10	have	have	VERB
admet-2268	28	11	limitations	limitation	NOUN
admet-2268	28	12	and	and	CCONJ
admet-2268	28	13	unfavourable	unfavourable	ADJ
admet-2268	28	14	outcomes	outcome	NOUN
admet-2268	28	15	,	,	PUNCT
admet-2268	28	16	which	which	PRON
admet-2268	28	17	make	make	VERB
admet-2268	28	18	it	it	PRON
admet-2268	28	19	difficult	difficult	ADJ
admet-2268	28	20	to	to	PART
admet-2268	28	21	use	use	VERB
admet-2268	28	22	them	they	PRON
admet-2268	28	23	in	in	ADP
admet-2268	28	24	clinical	clinical	ADJ
admet-2268	28	25	settings	setting	NOUN
admet-2268	28	26	[	[	X
admet-2268	28	27	4	4	NUM
admet-2268	28	28	-	-	SYM
admet-2268	28	29	7	7	NUM
admet-2268	28	30	]	]	PUNCT
admet-2268	28	31	.	.	PUNCT
admet-2268	29	1	topical	topical	ADJ
admet-2268	29	2	drug	drug	NOUN
admet-2268	29	3	delivery	delivery	NOUN
admet-2268	29	4	focuses	focus	VERB
admet-2268	29	5	on	on	ADP
admet-2268	29	6	localized	localized	ADJ
admet-2268	29	7	treatment	treatment	NOUN
admet-2268	29	8	by	by	ADP
admet-2268	29	9	applying	apply	VERB
admet-2268	29	10	drugs	drug	NOUN
admet-2268	29	11	directly	directly	ADV
admet-2268	29	12	to	to	ADP
admet-2268	29	13	the	the	DET
admet-2268	29	14	skin	skin	NOUN
admet-2268	29	15	's	's	PART
admet-2268	29	16	surface	surface	NOUN
admet-2268	29	17	,	,	PUNCT
admet-2268	29	18	allowing	allow	VERB
admet-2268	29	19	for	for	ADP
admet-2268	29	20	targeted	target	VERB
admet-2268	29	21	action	action	NOUN
admet-2268	29	22	at	at	ADP
admet-2268	29	23	the	the	DET
admet-2268	29	24	application	application	NOUN
admet-2268	29	25	site	site	NOUN
admet-2268	29	26	while	while	SCONJ
admet-2268	29	27	reducing	reduce	VERB
admet-2268	29	28	systemic	systemic	ADJ
admet-2268	29	29	side	side	NOUN
admet-2268	29	30	effects	effect	NOUN
admet-2268	29	31	.	.	PUNCT
admet-2268	30	1	this	this	DET
admet-2268	30	2	method	method	NOUN
admet-2268	30	3	is	be	AUX
admet-2268	30	4	especially	especially	ADV
admet-2268	30	5	useful	useful	ADJ
admet-2268	30	6	for	for	ADP
admet-2268	30	7	treating	treat	VERB
admet-2268	30	8	skin	skin	NOUN
admet-2268	30	9	disorders	disorder	NOUN
admet-2268	30	10	like	like	ADP
admet-2268	30	11	psoriasis	psoriasis	NOUN
admet-2268	30	12	,	,	PUNCT
admet-2268	30	13	as	as	SCONJ
admet-2268	30	14	it	it	PRON
admet-2268	30	15	can	can	AUX
admet-2268	30	16	improve	improve	VERB
admet-2268	30	17	treatment	treatment	NOUN
admet-2268	30	18	efficacy	efficacy	NOUN
admet-2268	30	19	and	and	CCONJ
admet-2268	30	20	patient	patient	ADJ
admet-2268	30	21	compliance	compliance	NOUN
admet-2268	30	22	[	[	X
admet-2268	30	23	8	8	NUM
admet-2268	30	24	]	]	PUNCT
admet-2268	30	25	.	.	PUNCT
admet-2268	31	1	promising	promise	VERB
admet-2268	31	2	developments	development	NOUN
admet-2268	31	3	in	in	ADP
admet-2268	31	4	nanotechnology	nanotechnology	NOUN
admet-2268	31	5	have	have	AUX
admet-2268	31	6	led	lead	VERB
admet-2268	31	7	to	to	ADP
admet-2268	31	8	the	the	DET
admet-2268	31	9	development	development	NOUN
admet-2268	31	10	of	of	ADP
admet-2268	31	11	nanoparticulate	nanoparticulate	ADJ
admet-2268	31	12	drug	drug	NOUN
admet-2268	31	13	carriers	carrier	NOUN
admet-2268	31	14	,	,	PUNCT
admet-2268	31	15	which	which	PRON
admet-2268	31	16	hold	hold	VERB
admet-2268	31	17	immense	immense	ADJ
admet-2268	31	18	promise	promise	NOUN
admet-2268	31	19	for	for	ADP
admet-2268	31	20	treating	treat	VERB
admet-2268	31	21	a	a	DET
admet-2268	31	22	wide	wide	ADJ
admet-2268	31	23	range	range	NOUN
admet-2268	31	24	of	of	ADP
admet-2268	31	25	diseases	disease	NOUN
admet-2268	31	26	.	.	PUNCT
admet-2268	32	1	nanomedicines	nanomedicine	NOUN
admet-2268	32	2	are	be	AUX
admet-2268	32	3	promising	promise	VERB
admet-2268	32	4	therapeutics	therapeutic	NOUN
admet-2268	32	5	for	for	ADP
admet-2268	32	6	topical	topical	ADJ
admet-2268	32	7	drug	drug	NOUN
admet-2268	32	8	delivery	delivery	NOUN
admet-2268	32	9	.	.	PUNCT
admet-2268	33	1	transferosomes	transferosome	NOUN
admet-2268	33	2	are	be	AUX
admet-2268	33	3	a	a	DET
admet-2268	33	4	unique	unique	ADJ
admet-2268	33	5	type	type	NOUN
admet-2268	33	6	of	of	ADP
admet-2268	33	7	vesicle	vesicle	NOUN
admet-2268	33	8	consisting	consist	VERB
admet-2268	33	9	of	of	ADP
admet-2268	33	10	concentric	concentric	ADJ
admet-2268	33	11	layers	layer	NOUN
admet-2268	33	12	made	make	VERB
admet-2268	33	13	up	up	ADP
admet-2268	33	14	of	of	ADP
admet-2268	33	15	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	33	16	(	(	PUNCT
admet-2268	33	17	c18	c18	NOUN
admet-2268	33	18	)	)	PUNCT
admet-2268	33	19	,	,	PUNCT
admet-2268	33	20	cholesterol	cholesterol	NOUN
admet-2268	33	21	,	,	PUNCT
admet-2268	33	22	and	and	CCONJ
admet-2268	33	23	an	an	DET
admet-2268	33	24	edge	edge	NOUN
admet-2268	33	25	activator	activator	NOUN
admet-2268	33	26	and	and	CCONJ
admet-2268	33	27	possess	possess	VERB
admet-2268	33	28	either	either	CCONJ
admet-2268	33	29	an	an	DET
admet-2268	33	30	aqueous	aqueous	ADJ
admet-2268	33	31	or	or	CCONJ
admet-2268	33	32	ethanolic	ethanolic	ADJ
admet-2268	33	33	core	core	NOUN
admet-2268	34	1	[	[	X
admet-2268	34	2	9	9	NUM
admet-2268	34	3	]	]	PUNCT
admet-2268	34	4	.	.	PUNCT
admet-2268	35	1	phosphatidylcholine	phosphatidylcholine	PROPN
admet-2268	35	2	is	be	AUX
admet-2268	35	3	the	the	DET
admet-2268	35	4	predominant	predominant	ADJ
admet-2268	35	5	phospholipid	phospholipid	NOUN
admet-2268	35	6	found	find	VERB
admet-2268	35	7	in	in	ADP
admet-2268	35	8	the	the	DET
admet-2268	35	9	cell	cell	NOUN
admet-2268	35	10	membranes	membrane	NOUN
admet-2268	35	11	of	of	ADP
admet-2268	35	12	eukaryotic	eukaryotic	ADJ
admet-2268	35	13	organisms	organism	NOUN
admet-2268	35	14	.	.	PUNCT
admet-2268	36	1	consequently	consequently	ADV
admet-2268	36	2	,	,	PUNCT
admet-2268	36	3	it	it	PRON
admet-2268	36	4	demonstrates	demonstrate	VERB
admet-2268	36	5	a	a	DET
admet-2268	36	6	notable	notable	ADJ
admet-2268	36	7	degree	degree	NOUN
admet-2268	36	8	of	of	ADP
admet-2268	36	9	skin	skin	NOUN
admet-2268	36	10	tolerance	tolerance	NOUN
admet-2268	36	11	,	,	PUNCT
admet-2268	36	12	thereby	thereby	ADV
admet-2268	36	13	decreasing	decrease	VERB
admet-2268	36	14	the	the	DET
admet-2268	36	15	probability	probability	NOUN
admet-2268	36	16	of	of	ADP
admet-2268	36	17	negative	negative	ADJ
admet-2268	36	18	effects	effect	NOUN
admet-2268	36	19	such	such	ADJ
admet-2268	36	20	as	as	ADP
admet-2268	36	21	hypersensitivity	hypersensitivity	NOUN
admet-2268	36	22	reactions	reaction	NOUN
admet-2268	36	23	that	that	PRON
admet-2268	36	24	make	make	VERB
admet-2268	36	25	them	they	PRON
admet-2268	36	26	suitable	suitable	ADJ
admet-2268	36	27	for	for	ADP
admet-2268	36	28	delivering	deliver	VERB
admet-2268	36	29	drugs	drug	NOUN
admet-2268	36	30	to	to	ADP
admet-2268	36	31	sensitive	sensitive	ADJ
admet-2268	36	32	areas	area	NOUN
admet-2268	36	33	[	[	X
admet-2268	36	34	2	2	NUM
admet-2268	36	35	]	]	PUNCT
admet-2268	36	36	.	.	PUNCT
admet-2268	37	1	edge	edge	NOUN
admet-2268	37	2	activators	activator	NOUN
admet-2268	37	3	possess	possess	VERB
admet-2268	37	4	exceptional	exceptional	ADJ
admet-2268	37	5	deformability	deformability	NOUN
admet-2268	37	6	and	and	CCONJ
admet-2268	37	7	flexibility	flexibility	NOUN
admet-2268	37	8	,	,	PUNCT
admet-2268	37	9	enabling	enable	VERB
admet-2268	37	10	them	they	PRON
admet-2268	37	11	to	to	PART
admet-2268	37	12	traverse	traverse	VERB
admet-2268	37	13	the	the	DET
admet-2268	37	14	stratum	stratum	NOUN
admet-2268	37	15	corneum	corneum	VERB
admet-2268	37	16	effortlessly	effortlessly	ADV
admet-2268	37	17	without	without	ADP
admet-2268	37	18	encountering	encounter	VERB
admet-2268	37	19	issues	issue	NOUN
admet-2268	37	20	such	such	ADJ
admet-2268	37	21	as	as	ADP
admet-2268	37	22	fracturing	fracturing	NOUN
admet-2268	37	23	or	or	CCONJ
admet-2268	37	24	leakage	leakage	NOUN
admet-2268	37	25	.	.	PUNCT
admet-2268	38	1	this	this	PRON
admet-2268	38	2	enhances	enhance	VERB
admet-2268	38	3	the	the	DET
admet-2268	38	4	delivery	delivery	NOUN
admet-2268	38	5	of	of	ADP
admet-2268	38	6	drugs	drug	NOUN
admet-2268	38	7	to	to	PART
admet-2268	38	8	target	target	VERB
admet-2268	38	9	tissues	tissue	NOUN
admet-2268	38	10	.	.	PUNCT
admet-2268	39	1	the	the	DET
admet-2268	39	2	flexible	flexible	ADJ
admet-2268	39	3	nature	nature	NOUN
admet-2268	39	4	of	of	ADP
admet-2268	39	5	transferosomes	transferosome	NOUN
admet-2268	39	6	allows	allow	VERB
admet-2268	39	7	them	they	PRON
admet-2268	39	8	to	to	PART
admet-2268	39	9	encapsulate	encapsulate	VERB
admet-2268	39	10	a	a	DET
admet-2268	39	11	higher	high	ADJ
admet-2268	39	12	drug	drug	NOUN
admet-2268	39	13	payload	payload	NOUN
admet-2268	39	14	,	,	PUNCT
admet-2268	39	15	leading	lead	VERB
admet-2268	39	16	to	to	ADP
admet-2268	39	17	improved	improved	ADJ
admet-2268	39	18	bioavailability	bioavailability	NOUN
admet-2268	39	19	as	as	ADP
admet-2268	39	20	more	more	ADJ
admet-2268	39	21	of	of	ADP
admet-2268	39	22	the	the	DET
admet-2268	39	23	drug	drug	NOUN
admet-2268	39	24	reaches	reach	VERB
admet-2268	39	25	the	the	DET
admet-2268	39	26	target	target	NOUN
admet-2268	39	27	site	site	NOUN
admet-2268	39	28	.	.	PUNCT
admet-2268	40	1	transferosomes	transferosome	NOUN
admet-2268	40	2	can	can	AUX
admet-2268	40	3	adapt	adapt	VERB
admet-2268	40	4	to	to	ADP
admet-2268	40	5	the	the	DET
admet-2268	40	6	skin	skin	NOUN
admet-2268	40	7	's	's	PART
admet-2268	40	8	topography	topography	NOUN
admet-2268	40	9	,	,	PUNCT
admet-2268	40	10	reducing	reduce	VERB
admet-2268	40	11	irritation	irritation	NOUN
admet-2268	40	12	and	and	CCONJ
admet-2268	40	13	minimizing	minimize	VERB
admet-2268	40	14	the	the	DET
admet-2268	40	15	potential	potential	NOUN
admet-2268	40	16	for	for	ADP
admet-2268	40	17	skin	skin	NOUN
admet-2268	40	18	damage	damage	NOUN
admet-2268	40	19	.	.	PUNCT
admet-2268	41	1	transferosomes	transferosome	NOUN
admet-2268	41	2	can	can	AUX
admet-2268	41	3	encapsulate	encapsulate	VERB
admet-2268	41	4	both	both	CCONJ
admet-2268	41	5	lipophilic	lipophilic	ADJ
admet-2268	41	6	and	and	CCONJ
admet-2268	41	7	hydrophilic	hydrophilic	ADJ
admet-2268	41	8	drugs	drug	NOUN
admet-2268	41	9	,	,	PUNCT
admet-2268	41	10	providing	provide	VERB
admet-2268	41	11	versatility	versatility	NOUN
admet-2268	41	12	in	in	ADP
admet-2268	41	13	formulation	formulation	NOUN
admet-2268	41	14	.	.	PUNCT
admet-2268	42	1	the	the	DET
admet-2268	42	2	lipid	lipid	NOUN
admet-2268	42	3	composition	composition	NOUN
admet-2268	42	4	of	of	ADP
admet-2268	42	5	transferosomes	transferosome	NOUN
admet-2268	42	6	contributes	contribute	VERB
admet-2268	42	7	to	to	ADP
admet-2268	42	8	their	their	PRON
admet-2268	42	9	stability	stability	NOUN
admet-2268	42	10	,	,	PUNCT
admet-2268	42	11	ensuring	ensure	VERB
admet-2268	42	12	the	the	DET
admet-2268	42	13	integrity	integrity	NOUN
admet-2268	42	14	of	of	ADP
admet-2268	42	15	the	the	DET
admet-2268	42	16	encapsulated	encapsulate	VERB
admet-2268	42	17	drug	drug	NOUN
admet-2268	42	18	during	during	ADP
admet-2268	42	19	storage	storage	NOUN
admet-2268	42	20	and	and	CCONJ
admet-2268	42	21	application	application	NOUN
admet-2268	42	22	.	.	PUNCT
admet-2268	43	1	this	this	PRON
admet-2268	43	2	leads	lead	VERB
admet-2268	43	3	to	to	ADP
admet-2268	43	4	a	a	DET
admet-2268	43	5	longer	long	ADJ
admet-2268	43	6	shelf	shelf	NOUN
admet-2268	43	7	life	life	NOUN
admet-2268	43	8	for	for	ADP
admet-2268	43	9	formulated	formulated	ADJ
admet-2268	43	10	products	product	NOUN
admet-2268	43	11	.	.	PUNCT
admet-2268	44	1	the	the	DET
admet-2268	44	2	topical	topical	ADJ
admet-2268	44	3	application	application	NOUN
admet-2268	44	4	of	of	ADP
admet-2268	44	5	transferosomes	transferosome	NOUN
admet-2268	44	6	is	be	AUX
admet-2268	44	7	non	non	ADJ
admet-2268	44	8	-	-	ADJ
admet-2268	44	9	invasive	invasive	ADJ
admet-2268	44	10	,	,	PUNCT
admet-2268	44	11	offering	offer	VERB
admet-2268	44	12	patients	patient	NOUN
admet-2268	44	13	convenience	convenience	VERB
admet-2268	44	14	and	and	CCONJ
admet-2268	44	15	potentially	potentially	ADV
admet-2268	44	16	improving	improve	VERB
admet-2268	44	17	compliance	compliance	NOUN
admet-2268	44	18	.	.	PUNCT
admet-2268	45	1	this	this	PRON
admet-2268	45	2	is	be	AUX
admet-2268	45	3	particularly	particularly	ADV
admet-2268	45	4	beneficial	beneficial	ADJ
admet-2268	45	5	for	for	ADP
admet-2268	45	6	conditions	condition	NOUN
admet-2268	45	7	where	where	SCONJ
admet-2268	45	8	systemic	systemic	ADJ
admet-2268	45	9	drug	drug	NOUN
admet-2268	45	10	delivery	delivery	NOUN
admet-2268	45	11	is	be	AUX
admet-2268	45	12	not	not	PART
admet-2268	45	13	required	require	VERB
admet-2268	45	14	.	.	PUNCT
admet-2268	46	1	compared	compare	VERB
admet-2268	46	2	to	to	ADP
admet-2268	46	3	liposomes	liposome	NOUN
admet-2268	46	4	and	and	CCONJ
admet-2268	46	5	niosomes	niosome	NOUN
admet-2268	46	6	,	,	PUNCT
admet-2268	46	7	they	they	PRON
admet-2268	46	8	exhibit	exhibit	VERB
admet-2268	46	9	a	a	DET
admet-2268	46	10	significant	significant	ADJ
admet-2268	46	11	degree	degree	NOUN
admet-2268	46	12	of	of	ADP
admet-2268	46	13	stability	stability	NOUN
admet-2268	46	14	in	in	ADP
admet-2268	46	15	water	water	NOUN
admet-2268	46	16	-	-	PUNCT
admet-2268	46	17	based	base	VERB
admet-2268	46	18	solutions	solution	NOUN
admet-2268	46	19	for	for	ADP
admet-2268	46	20	three	three	NUM
admet-2268	46	21	months	month	NOUN
admet-2268	46	22	[	[	X
admet-2268	46	23	10,11	10,11	NOUN
admet-2268	46	24	]	]	PUNCT
admet-2268	46	25	.	.	PUNCT
admet-2268	47	1	compared	compare	VERB
admet-2268	47	2	to	to	ADP
admet-2268	47	3	liposomes	liposome	NOUN
admet-2268	47	4	,	,	PUNCT
admet-2268	47	5	tacrolimus	tacrolimus	NOUN
admet-2268	47	6	-	-	PUNCT
admet-2268	47	7	loaded	load	VERB
admet-2268	47	8	transferosomes	transferosome	NOUN
admet-2268	47	9	had	have	VERB
admet-2268	47	10	a	a	DET
admet-2268	47	11	longer	long	ADJ
admet-2268	47	12	retention	retention	NOUN
admet-2268	47	13	time	time	NOUN
admet-2268	47	14	(	(	PUNCT
admet-2268	47	15	52.58±3.62	52.58±3.62	NUM
admet-2268	47	16	h	h	NOUN
admet-2268	47	17	)	)	PUNCT
admet-2268	47	18	and	and	CCONJ
admet-2268	47	19	better	well	ADJ
admet-2268	47	20	skin	skin	NOUN
admet-2268	47	21	permeation	permeation	NOUN
admet-2268	47	22	(	(	PUNCT
admet-2268	47	23	15.44±1.79	15.44±1.79	NUM
admet-2268	47	24	h	h	NOUN
admet-2268	47	25	)	)	PUNCT
admet-2268	47	26	.	.	PUNCT
admet-2268	48	1	compared	compare	VERB
admet-2268	48	2	to	to	ADP
admet-2268	48	3	liposomes	liposome	NOUN
admet-2268	48	4	,	,	PUNCT
admet-2268	48	5	optimised	optimise	VERB
admet-2268	48	6	transferosomes	transferosome	NOUN
admet-2268	48	7	exhibited	exhibit	VERB
admet-2268	48	8	superior	superior	ADJ
admet-2268	48	9	penetration	penetration	NOUN
admet-2268	48	10	(	(	PUNCT
admet-2268	48	11	15.44±1.79	15.44±1.79	NUM
admet-2268	48	12	h	h	NOUN
admet-2268	48	13	)	)	PUNCT
admet-2268	48	14	and	and	CCONJ
admet-2268	48	15	residence	residence	NOUN
admet-2268	48	16	time	time	NOUN
admet-2268	48	17	(	(	PUNCT
admet-2268	48	18	52.58±3.62	52.58±3.62	NUM
admet-2268	48	19	h	h	NOUN
admet-2268	48	20	)	)	PUNCT
admet-2268	48	21	in	in	ADP
admet-2268	48	22	rat	rat	NOUN
admet-2268	48	23	skin	skin	NOUN
admet-2268	48	24	.	.	PUNCT
admet-2268	49	1	transferosomes	transferosome	NOUN
admet-2268	49	2	minimize	minimize	VERB
admet-2268	49	3	ear	ear	NOUN
admet-2268	49	4	edema	edema	NOUN
admet-2268	49	5	while	while	SCONJ
admet-2268	49	6	increasing	increase	VERB
admet-2268	49	7	transdermal	transdermal	ADJ
admet-2268	49	8	flux	flux	NOUN
admet-2268	49	9	[	[	X
admet-2268	49	10	12	12	NUM
admet-2268	49	11	]	]	PUNCT
admet-2268	49	12	.	.	PUNCT
admet-2268	50	1	thin	thin	ADJ
admet-2268	50	2	film	film	NOUN
admet-2268	50	3	hydration	hydration	NOUN
admet-2268	50	4	approach	approach	NOUN
admet-2268	50	5	produced	produce	VERB
admet-2268	50	6	fluocinolone	fluocinolone	NOUN
admet-2268	50	7	acetonide	acetonide	ADV
admet-2268	50	8	-	-	PUNCT
admet-2268	50	9	loaded	load	VERB
admet-2268	50	10	transferosomes	transferosome	NOUN
admet-2268	50	11	with	with	ADP
admet-2268	50	12	high	high	ADJ
admet-2268	50	13	transdermal	transdermal	ADJ
admet-2268	50	14	flow	flow	NOUN
admet-2268	50	15	,	,	PUNCT
admet-2268	50	16	enhanced	enhance	VERB
admet-2268	50	17	cytotoxicity	cytotoxicity	NOUN
admet-2268	50	18	,	,	PUNCT
admet-2268	50	19	and	and	CCONJ
admet-2268	50	20	antiproliferative	antiproliferative	ADJ
admet-2268	50	21	efficacy	efficacy	NOUN
admet-2268	50	22	against	against	ADP
admet-2268	50	23	imiquimod	imiquimod	ADV
admet-2268	50	24	-	-	PUNCT
admet-2268	50	25	stimulated	stimulate	VERB
admet-2268	50	26	hacat	hacat	NUM
admet-2268	50	27	cells	cell	NOUN
admet-2268	50	28	.	.	PUNCT
admet-2268	51	1	transferosomes	transferosome	NOUN
admet-2268	51	2	decreased	decrease	VERB
admet-2268	51	3	il-6	il-6	NOUN
admet-2268	51	4	and	and	CCONJ
admet-2268	51	5	tnf	tnf	PROPN
admet-2268	51	6	-	-	PUNCT
admet-2268	51	7	α	α	PROPN
admet-2268	51	8	levels	level	NOUN
admet-2268	51	9	and	and	CCONJ
admet-2268	51	10	increased	increase	VERB
admet-2268	51	11	cellular	cellular	ADJ
admet-2268	51	12	absorption	absorption	NOUN
admet-2268	51	13	[	[	X
admet-2268	51	14	13	13	NUM
admet-2268	51	15	]	]	PUNCT
admet-2268	51	16	.	.	PUNCT
admet-2268	52	1	berberine	berberine	NOUN
admet-2268	52	2	,	,	PUNCT
admet-2268	52	3	a	a	DET
admet-2268	52	4	compound	compound	NOUN
admet-2268	52	5	present	present	NOUN
admet-2268	52	6	in	in	ADP
admet-2268	52	7	berberis	berberis	PROPN
admet-2268	52	8	vulgaris	vulgaris	NOUN
admet-2268	52	9	,	,	PUNCT
admet-2268	52	10	is	be	AUX
admet-2268	52	11	an	an	DET
admet-2268	52	12	alkaloid	alkaloid	ADJ
admet-2268	52	13	compound	compound	NOUN
admet-2268	52	14	showing	show	VERB
admet-2268	52	15	significant	significant	ADJ
admet-2268	52	16	anti	anti	ADJ
admet-2268	52	17	-	-	ADJ
admet-2268	52	18	inflammatory	inflammatory	ADJ
admet-2268	52	19	characteristics	characteristic	NOUN
admet-2268	52	20	.	.	PUNCT
admet-2268	53	1	it	it	PRON
admet-2268	53	2	displays	display	VERB
admet-2268	53	3	a	a	DET
admet-2268	53	4	distinct	distinct	ADJ
admet-2268	53	5	yellow	yellow	ADJ
admet-2268	53	6	crystalline	crystalline	NOUN
admet-2268	53	7	morphology	morphology	NOUN
admet-2268	53	8	and	and	CCONJ
admet-2268	53	9	exhibits	exhibit	VERB
admet-2268	53	10	significant	significant	ADJ
admet-2268	53	11	water	water	NOUN
admet-2268	53	12	insolubility	insolubility	NOUN
admet-2268	53	13	.	.	PUNCT
admet-2268	54	1	berberine	berberine	PROPN
admet-2268	54	2	suppresses	suppress	VERB
admet-2268	54	3	the	the	DET
admet-2268	54	4	jak	jak	PROPN
admet-2268	54	5	-	-	PUNCT
admet-2268	54	6	stat	stat	NOUN
admet-2268	54	7	pathway	pathway	NOUN
admet-2268	54	8	in	in	ADP
admet-2268	54	9	plaque	plaque	NOUN
admet-2268	54	10	psoriasis	psoriasis	NOUN
admet-2268	54	11	.	.	PUNCT
admet-2268	55	1	it	it	PRON
admet-2268	55	2	decreases	decrease	VERB
admet-2268	55	3	the	the	DET
admet-2268	55	4	levels	level	NOUN
admet-2268	55	5	of	of	ADP
admet-2268	55	6	pro	pro	ADJ
admet-2268	55	7	-	-	ADJ
admet-2268	55	8	inflammatory	inflammatory	ADJ
admet-2268	55	9	and	and	CCONJ
admet-2268	55	10	inflammatory	inflammatory	ADJ
admet-2268	55	11	cytokines	cytokine	NOUN
admet-2268	55	12	,	,	PUNCT
admet-2268	55	13	including	include	VERB
admet-2268	55	14	tumour	tumour	NOUN
admet-2268	55	15	necrosis	necrosis	NOUN
admet-2268	55	16	factor	factor	NOUN
admet-2268	55	17	-	-	PUNCT
admet-2268	55	18	alpha	alpha	NOUN
admet-2268	55	19	(	(	PUNCT
admet-2268	55	20	tnf-𝛼	tnf-𝛼	PROPN
admet-2268	55	21	,	,	PUNCT
admet-2268	55	22	ifn-𝛾	ifn-𝛾	NUM
admet-2268	55	23	)	)	PUNCT
admet-2268	55	24	and	and	CCONJ
admet-2268	55	25	interleukin	interleukin	NOUN
admet-2268	55	26	(	(	PUNCT
admet-2268	55	27	il-23	il-23	NOUN
admet-2268	55	28	,	,	PUNCT
admet-2268	55	29	il-12	il-12	NOUN
admet-2268	55	30	,	,	PUNCT
admet-2268	55	31	and	and	CCONJ
admet-2268	55	32	il-23	il-23	NOUN
admet-2268	55	33	)	)	PUNCT
admet-2268	56	1	[	[	X
admet-2268	56	2	14,15	14,15	NUM
admet-2268	56	3	]	]	PUNCT
admet-2268	56	4	.	.	PUNCT
admet-2268	57	1	diacerein	diacerein	PROPN
admet-2268	57	2	has	have	AUX
admet-2268	57	3	been	be	AUX
admet-2268	57	4	licensed	license	VERB
admet-2268	57	5	by	by	ADP
admet-2268	57	6	the	the	DET
admet-2268	57	7	european	european	PROPN
admet-2268	57	8	medicines	medicines	PROPN
admet-2268	57	9	agency	agency	NOUN
admet-2268	57	10	and	and	CCONJ
admet-2268	57	11	the	the	DET
admet-2268	57	12	us	us	PROPN
admet-2268	57	13	food	food	NOUN
admet-2268	57	14	and	and	CCONJ
admet-2268	57	15	drug	drug	NOUN
admet-2268	57	16	administration	administration	NOUN
admet-2268	57	17	for	for	ADP
admet-2268	57	18	the	the	DET
admet-2268	57	19	treatment	treatment	NOUN
admet-2268	57	20	of	of	ADP
admet-2268	57	21	rheumatoid	rheumatoid	NOUN
admet-2268	57	22	arthritis	arthritis	NOUN
admet-2268	57	23	.	.	PUNCT
admet-2268	58	1	diacerein	diacerein	PROPN
admet-2268	58	2	inhibits	inhibit	VERB
admet-2268	58	3	the	the	DET
admet-2268	58	4	synthesis	synthesis	NOUN
admet-2268	58	5	of	of	ADP
admet-2268	58	6	il-12	il-12	NOUN
admet-2268	58	7	and	and	CCONJ
admet-2268	58	8	tnf	tnf	PROPN
admet-2268	58	9	-	-	PUNCT
admet-2268	58	10	α	α	PROPN
admet-2268	58	11	.	.	PUNCT
admet-2268	59	1	diacerein	diacerein	PROPN
admet-2268	59	2	significantly	significantly	ADV
admet-2268	59	3	reduces	reduce	VERB
admet-2268	59	4	the	the	DET
admet-2268	59	5	splenomegaly	splenomegaly	NOUN
admet-2268	59	6	associated	associate	VERB
admet-2268	59	7	with	with	ADP
admet-2268	59	8	psoriasis	psoriasis	NOUN
admet-2268	59	9	[	[	X
admet-2268	59	10	16,17	16,17	NUM
admet-2268	59	11	]	]	PUNCT
admet-2268	59	12	.	.	PUNCT
admet-2268	60	1	the	the	DET
admet-2268	60	2	main	main	ADJ
admet-2268	60	3	aim	aim	NOUN
admet-2268	60	4	of	of	ADP
admet-2268	60	5	this	this	DET
admet-2268	60	6	study	study	NOUN
admet-2268	60	7	is	be	AUX
admet-2268	60	8	to	to	PART
admet-2268	60	9	develop	develop	VERB
admet-2268	60	10	transferosomes	transferosome	NOUN
admet-2268	60	11	containing	contain	VERB
admet-2268	60	12	controlled	control	VERB
admet-2268	60	13	delivery	delivery	NOUN
admet-2268	60	14	of	of	ADP
admet-2268	60	15	berberine	berberine	NOUN
admet-2268	60	16	hydrochloride	hydrochloride	NOUN
admet-2268	60	17	and	and	CCONJ
admet-2268	60	18	diacerein	diacerein	VERB
admet-2268	60	19	for	for	ADP
admet-2268	60	20	better	well	ADJ
admet-2268	60	21	management	management	NOUN
admet-2268	60	22	of	of	ADP
admet-2268	60	23	psoriasis	psoriasis	NOUN
admet-2268	60	24	.	.	PUNCT
admet-2268	61	1	to	to	PART
admet-2268	61	2	achieve	achieve	VERB
admet-2268	61	3	this	this	DET
admet-2268	61	4	objective	objective	NOUN
admet-2268	61	5	,	,	PUNCT
admet-2268	61	6	the	the	DET
admet-2268	61	7	thin	thin	ADJ
admet-2268	61	8	film	film	NOUN
admet-2268	61	9	hydration	hydration	NOUN
admet-2268	61	10	admet	admet	PROPN
admet-2268	61	11	&	&	CCONJ
admet-2268	61	12	dmpk	dmpk	PROPN
admet-2268	61	13	12(3	12(3	PROPN
admet-2268	61	14	)	)	PUNCT
admet-2268	61	15	(	(	PUNCT
admet-2268	61	16	2024	2024	NUM
admet-2268	61	17	)	)	PUNCT
admet-2268	61	18	553	553	NUM
admet-2268	61	19	-	-	SYM
admet-2268	61	20	580	580	NUM
admet-2268	61	21	berberine	berberine	NOUN
admet-2268	61	22	hcl	hcl	PROPN
admet-2268	61	23	and	and	CCONJ
admet-2268	61	24	diacerein	diacerein	ADV
admet-2268	61	25	loaded	load	VERB
admet-2268	61	26	dual	dual	ADJ
admet-2268	61	27	delivery	delivery	NOUN
admet-2268	61	28	transferosomes	transferosome	NOUN
admet-2268	61	29	doi	doi	PROPN
admet-2268	61	30	:	:	PUNCT
admet-2268	61	31	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	61	32	555	555	NUM
admet-2268	61	33	method	method	NOUN
admet-2268	61	34	was	be	AUX
admet-2268	61	35	used	use	VERB
admet-2268	61	36	to	to	PART
admet-2268	61	37	formulate	formulate	VERB
admet-2268	61	38	transferosomes	transferosome	NOUN
admet-2268	61	39	,	,	PUNCT
admet-2268	61	40	which	which	PRON
admet-2268	61	41	were	be	AUX
admet-2268	61	42	then	then	ADV
admet-2268	61	43	tested	test	VERB
admet-2268	61	44	for	for	ADP
admet-2268	61	45	particle	particle	NOUN
admet-2268	61	46	and	and	CCONJ
admet-2268	61	47	ζ	ζ	NOUN
admet-2268	61	48	potential	potential	NOUN
admet-2268	61	49	,	,	PUNCT
admet-2268	61	50	drug	drug	NOUN
admet-2268	61	51	loading	loading	NOUN
admet-2268	61	52	,	,	PUNCT
admet-2268	61	53	encapsulation	encapsulation	NOUN
admet-2268	61	54	efficiency	efficiency	NOUN
admet-2268	61	55	,	,	PUNCT
admet-2268	61	56	morphology	morphology	NOUN
admet-2268	61	57	,	,	PUNCT
admet-2268	61	58	degree	degree	NOUN
admet-2268	61	59	of	of	ADP
admet-2268	61	60	deformability	deformability	NOUN
admet-2268	61	61	,	,	PUNCT
admet-2268	61	62	drug	drug	NOUN
admet-2268	61	63	release	release	NOUN
admet-2268	61	64	,	,	PUNCT
admet-2268	61	65	and	and	CCONJ
admet-2268	61	66	ex	ex	PRON
admet-2268	61	67	vivo	vivo	ADJ
admet-2268	61	68	skin	skin	NOUN
admet-2268	61	69	permeation	permeation	NOUN
admet-2268	61	70	.	.	PUNCT
admet-2268	62	1	experimental	experimental	ADJ
admet-2268	62	2	materials	material	NOUN
admet-2268	62	3	berberine	berberine	NOUN
admet-2268	62	4	hcl	hcl	PROPN
admet-2268	62	5	and	and	CCONJ
admet-2268	62	6	diacerein	diacerein	ADJ
admet-2268	62	7	were	be	AUX
admet-2268	62	8	purchased	purchase	VERB
admet-2268	62	9	from	from	ADP
admet-2268	62	10	yarrow	yarrow	NOUN
admet-2268	62	11	chem	chem	NOUN
admet-2268	62	12	products	product	NOUN
admet-2268	62	13	,	,	PUNCT
admet-2268	62	14	mumbai	mumbai	PROPN
admet-2268	62	15	,	,	PUNCT
admet-2268	62	16	india	india	PROPN
admet-2268	62	17	.	.	PUNCT
admet-2268	63	1	methanol	methanol	NOUN
admet-2268	63	2	and	and	CCONJ
admet-2268	63	3	chloroform	chloroform	NOUN
admet-2268	63	4	were	be	AUX
admet-2268	63	5	obtained	obtain	VERB
admet-2268	63	6	from	from	ADP
admet-2268	63	7	sigma	sigma	PROPN
admet-2268	63	8	aldrich	aldrich	PROPN
admet-2268	63	9	(	(	PUNCT
admet-2268	63	10	ma	ma	PROPN
admet-2268	63	11	,	,	PUNCT
admet-2268	63	12	united	united	PROPN
admet-2268	63	13	states	states	PROPN
admet-2268	63	14	)	)	PUNCT
admet-2268	63	15	.	.	PUNCT
admet-2268	64	1	sodium	sodium	PROPN
admet-2268	64	2	deoxycholate	deoxycholate	PROPN
admet-2268	64	3	was	be	AUX
admet-2268	64	4	purchased	purchase	VERB
admet-2268	64	5	from	from	ADP
admet-2268	64	6	sd	sd	ADP
admet-2268	64	7	fine	fine	ADJ
admet-2268	64	8	chemicals	chemical	NOUN
admet-2268	64	9	(	(	PUNCT
admet-2268	64	10	mumbai	mumbai	PROPN
admet-2268	64	11	,	,	PUNCT
admet-2268	64	12	india	india	PROPN
admet-2268	64	13	)	)	PUNCT
admet-2268	64	14	.	.	PUNCT
admet-2268	65	1	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	65	2	,	,	PUNCT
admet-2268	65	3	sodium	sodium	NOUN
admet-2268	65	4	hydroxide	hydroxide	NOUN
admet-2268	65	5	,	,	PUNCT
admet-2268	65	6	and	and	CCONJ
admet-2268	65	7	potassium	potassium	NOUN
admet-2268	65	8	dihydrogen	dihydrogen	NOUN
admet-2268	65	9	phosphate	phosphate	NOUN
admet-2268	65	10	were	be	AUX
admet-2268	65	11	purchased	purchase	VERB
admet-2268	65	12	from	from	ADP
admet-2268	65	13	srl	srl	PROPN
admet-2268	65	14	chemicals	chemical	NOUN
admet-2268	65	15	(	(	PUNCT
admet-2268	65	16	mumbai	mumbai	PROPN
admet-2268	65	17	,	,	PUNCT
admet-2268	65	18	india	india	PROPN
admet-2268	65	19	)	)	PUNCT
admet-2268	65	20	.	.	PUNCT
admet-2268	66	1	dialysis	dialysis	NOUN
admet-2268	66	2	membrane	membrane	NOUN
admet-2268	66	3	(	(	PUNCT
admet-2268	66	4	molecular	molecular	ADJ
admet-2268	66	5	weight	weight	NOUN
admet-2268	66	6	cut	cut	VERB
admet-2268	66	7	off	off	ADP
admet-2268	66	8	12000	12000	NUM
admet-2268	66	9	da	da	NOUN
admet-2268	66	10	)	)	PUNCT
admet-2268	66	11	was	be	AUX
admet-2268	66	12	procured	procure	VERB
admet-2268	66	13	from	from	ADP
admet-2268	66	14	hi	hi	ADJ
admet-2268	66	15	-	-	PUNCT
admet-2268	66	16	media	medium	NOUN
admet-2268	66	17	laboratory	laboratory	NOUN
admet-2268	66	18	(	(	PUNCT
admet-2268	66	19	mumbai	mumbai	PROPN
admet-2268	66	20	,	,	PUNCT
admet-2268	66	21	india	india	PROPN
admet-2268	66	22	)	)	PUNCT
admet-2268	66	23	.	.	PUNCT
admet-2268	67	1	preparation	preparation	NOUN
admet-2268	67	2	of	of	ADP
admet-2268	67	3	berberine	berberine	PROPN
admet-2268	67	4	hcl	hcl	PROPN
admet-2268	67	5	-	-	PUNCT
admet-2268	67	6	diacerein	diacerein	PROPN
admet-2268	67	7	loaded	load	VERB
admet-2268	67	8	dual	dual	ADJ
admet-2268	67	9	delivery	delivery	NOUN
admet-2268	67	10	transferosomes	transferosome	NOUN
admet-2268	67	11	utilizing	utilize	VERB
admet-2268	67	12	a	a	DET
admet-2268	67	13	digital	digital	ADJ
admet-2268	67	14	rotatory	rotatory	ADJ
admet-2268	67	15	evaporator	evaporator	NOUN
admet-2268	67	16	(	(	PUNCT
admet-2268	67	17	dlab	dlab	X
admet-2268	67	18	re	re	ADJ
admet-2268	67	19	100	100	NUM
admet-2268	67	20	-	-	PUNCT
admet-2268	67	21	pro	pro	ADJ
admet-2268	67	22	,	,	PUNCT
admet-2268	67	23	thermo	thermo	NOUN
admet-2268	67	24	life	life	NOUN
admet-2268	67	25	sciences	sciences	PROPN
admet-2268	67	26	,	,	PUNCT
admet-2268	67	27	mumbai	mumbai	PROPN
admet-2268	67	28	,	,	PUNCT
admet-2268	67	29	india	india	PROPN
admet-2268	67	30	)	)	PUNCT
admet-2268	67	31	,	,	PUNCT
admet-2268	67	32	berberine	berberine	NOUN
admet-2268	67	33	hcl	hcl	PROPN
admet-2268	67	34	and	and	CCONJ
admet-2268	67	35	diacerein	diacerein	ADV
admet-2268	67	36	-	-	PUNCT
admet-2268	67	37	loaded	load	VERB
admet-2268	67	38	transferosomes	transferosome	NOUN
admet-2268	67	39	were	be	AUX
admet-2268	67	40	prepared	prepare	VERB
admet-2268	67	41	by	by	ADP
admet-2268	67	42	the	the	DET
admet-2268	67	43	thin	thin	ADJ
admet-2268	67	44	film	film	NOUN
admet-2268	67	45	hydration	hydration	NOUN
admet-2268	67	46	method	method	NOUN
admet-2268	67	47	.	.	PUNCT
admet-2268	68	1	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	68	2	,	,	PUNCT
admet-2268	68	3	sodium	sodium	NOUN
admet-2268	68	4	deoxycholate	deoxycholate	VERB
admet-2268	68	5	,	,	PUNCT
admet-2268	68	6	and	and	CCONJ
admet-2268	68	7	diacerein	diacerein	ADJ
admet-2268	68	8	were	be	AUX
admet-2268	68	9	weighed	weigh	VERB
admet-2268	68	10	and	and	CCONJ
admet-2268	68	11	dissolved	dissolve	VERB
admet-2268	68	12	in	in	ADP
admet-2268	68	13	a	a	DET
admet-2268	68	14	chloroform	chloroform	NOUN
admet-2268	68	15	and	and	CCONJ
admet-2268	68	16	methanol	methanol	NOUN
admet-2268	68	17	mixture	mixture	NOUN
admet-2268	68	18	(	(	PUNCT
admet-2268	68	19	2:1	2:1	NUM
admet-2268	68	20	ratio	ratio	NOUN
admet-2268	68	21	)	)	PUNCT
admet-2268	68	22	.	.	PUNCT
admet-2268	69	1	the	the	DET
admet-2268	69	2	flask	flask	NOUN
admet-2268	69	3	was	be	AUX
admet-2268	69	4	rotated	rotate	VERB
admet-2268	69	5	at	at	ADP
admet-2268	69	6	100	100	NUM
admet-2268	69	7	rpm	rpm	NOUN
admet-2268	69	8	and	and	CCONJ
admet-2268	69	9	47	47	NUM
admet-2268	69	10	°	°	NOUN
admet-2268	69	11	c	c	NOUN
admet-2268	69	12	for	for	ADP
admet-2268	69	13	30	30	NUM
admet-2268	69	14	minutes	minute	NOUN
admet-2268	69	15	to	to	PART
admet-2268	69	16	form	form	VERB
admet-2268	69	17	a	a	DET
admet-2268	69	18	thin	thin	ADJ
admet-2268	69	19	film	film	NOUN
admet-2268	69	20	.	.	PUNCT
admet-2268	70	1	the	the	DET
admet-2268	70	2	flask	flask	NOUN
admet-2268	70	3	was	be	AUX
admet-2268	70	4	kept	keep	VERB
admet-2268	70	5	in	in	ADP
admet-2268	70	6	a	a	DET
admet-2268	70	7	desiccator	desiccator	NOUN
admet-2268	70	8	for	for	ADP
admet-2268	70	9	24	24	NUM
admet-2268	70	10	h.	h.	PROPN
admet-2268	70	11	berberine	berberine	PROPN
admet-2268	70	12	hcl	hcl	PROPN
admet-2268	70	13	was	be	AUX
admet-2268	70	14	dissolved	dissolve	VERB
admet-2268	70	15	in	in	ADP
admet-2268	70	16	the	the	DET
admet-2268	70	17	phosphate	phosphate	ADJ
admet-2268	70	18	buffer	buffer	NOUN
admet-2268	70	19	(	(	PUNCT
admet-2268	70	20	pbs	pbs	PROPN
admet-2268	70	21	ph	ph	PROPN
admet-2268	70	22	7.4	7.4	NUM
admet-2268	70	23	)	)	PUNCT
admet-2268	70	24	and	and	CCONJ
admet-2268	70	25	used	use	VERB
admet-2268	70	26	for	for	ADP
admet-2268	70	27	film	film	NOUN
admet-2268	70	28	hydration	hydration	NOUN
admet-2268	70	29	at	at	ADP
admet-2268	70	30	37	37	NUM
admet-2268	70	31	°	°	NOUN
admet-2268	70	32	c	c	NOUN
admet-2268	70	33	for	for	ADP
admet-2268	70	34	1	1	NUM
admet-2268	70	35	h	h	NOUN
admet-2268	70	36	(	(	PUNCT
admet-2268	70	37	table	table	NOUN
admet-2268	70	38	1	1	NUM
admet-2268	70	39	)	)	PUNCT
admet-2268	70	40	.	.	PUNCT
admet-2268	71	1	to	to	PART
admet-2268	71	2	obtain	obtain	VERB
admet-2268	71	3	drug	drug	NOUN
admet-2268	71	4	-	-	PUNCT
admet-2268	71	5	loaded	load	VERB
admet-2268	71	6	transferosomes	transferosome	NOUN
admet-2268	71	7	,	,	PUNCT
admet-2268	71	8	the	the	DET
admet-2268	71	9	mixture	mixture	NOUN
admet-2268	71	10	underwent	underwent	NOUN
admet-2268	71	11	sonication	sonication	NOUN
admet-2268	71	12	by	by	ADP
admet-2268	71	13	a	a	DET
admet-2268	71	14	probe	probe	NOUN
admet-2268	71	15	sonicator	sonicator	NOUN
admet-2268	71	16	at	at	ADP
admet-2268	71	17	three	three	NUM
admet-2268	71	18	different	different	ADJ
admet-2268	71	19	intervals	interval	NOUN
admet-2268	71	20	(	(	PUNCT
admet-2268	71	21	1	1	NUM
admet-2268	71	22	,	,	PUNCT
admet-2268	71	23	3	3	NUM
admet-2268	71	24	,	,	PUNCT
admet-2268	71	25	and	and	CCONJ
admet-2268	71	26	5	5	NUM
admet-2268	71	27	min	min	NOUN
admet-2268	71	28	)	)	PUNCT
admet-2268	71	29	with	with	ADP
admet-2268	71	30	a	a	DET
admet-2268	71	31	pulse	pulse	NOUN
admet-2268	71	32	of	of	ADP
admet-2268	71	33	20	20	NUM
admet-2268	71	34	seconds	second	NOUN
admet-2268	71	35	on	on	ADP
admet-2268	71	36	and	and	CCONJ
admet-2268	71	37	off	off	ADV
admet-2268	71	38	to	to	PART
admet-2268	71	39	obtain	obtain	VERB
admet-2268	71	40	the	the	DET
admet-2268	71	41	berberine	berberine	NOUN
admet-2268	71	42	hcl	hcl	PROPN
admet-2268	71	43	-	-	PUNCT
admet-2268	71	44	diacerein	diacerein	ADV
admet-2268	71	45	loaded	load	VERB
admet-2268	71	46	-	-	PUNCT
admet-2268	71	47	loaded	load	VERB
admet-2268	71	48	transferosomes	transferosome	NOUN
admet-2268	72	1	[	[	X
admet-2268	72	2	18	18	NUM
admet-2268	72	3	]	]	PUNCT
admet-2268	72	4	.	.	PUNCT
admet-2268	73	1	transferosomes	transferosome	NOUN
admet-2268	73	2	were	be	AUX
admet-2268	73	3	kept	keep	VERB
admet-2268	73	4	in	in	ADP
admet-2268	73	5	a	a	DET
admet-2268	73	6	deep	deep	ADJ
admet-2268	73	7	freezer	freezer	NOUN
admet-2268	73	8	(	(	PUNCT
admet-2268	73	9	ult-185	ult-185	NOUN
admet-2268	73	10	,	,	PUNCT
admet-2268	73	11	remi	remi	PROPN
admet-2268	73	12	,	,	PUNCT
admet-2268	73	13	india	india	PROPN
admet-2268	73	14	)	)	PUNCT
admet-2268	73	15	at	at	ADP
admet-2268	73	16	-20	-20	PROPN
admet-2268	73	17	°	°	ADP
admet-2268	73	18	c	c	NOUN
admet-2268	73	19	for	for	ADP
admet-2268	73	20	24	24	NUM
admet-2268	73	21	h.	h.	NOUN
admet-2268	73	22	the	the	DET
admet-2268	73	23	product	product	NOUN
admet-2268	73	24	was	be	AUX
admet-2268	73	25	lyophilized	lyophilize	VERB
admet-2268	73	26	at	at	ADP
admet-2268	73	27	-45	-45	PUNCT
admet-2268	73	28	°	°	ADP
admet-2268	73	29	c	c	NOUN
admet-2268	73	30	under	under	ADP
admet-2268	73	31	a	a	DET
admet-2268	73	32	suitable	suitable	ADJ
admet-2268	73	33	vacuum	vacuum	NOUN
admet-2268	73	34	for	for	ADP
admet-2268	73	35	24	24	NUM
admet-2268	73	36	h	h	NOUN
admet-2268	73	37	(	(	PUNCT
admet-2268	73	38	alpha	alpha	NOUN
admet-2268	73	39	2	2	NUM
admet-2268	73	40	-	-	SYM
admet-2268	73	41	4	4	NUM
admet-2268	73	42	lscplus	lscplus	NOUN
admet-2268	73	43	,	,	PUNCT
admet-2268	73	44	christ	christ	PROPN
admet-2268	73	45	,	,	PUNCT
admet-2268	73	46	germany	germany	PROPN
admet-2268	73	47	)	)	PUNCT
admet-2268	74	1	[	[	X
admet-2268	74	2	19	19	NUM
admet-2268	74	3	]	]	PUNCT
admet-2268	74	4	.	.	PUNCT
admet-2268	75	1	experimental	experimental	ADJ
admet-2268	75	2	design	design	NOUN
admet-2268	75	3	for	for	ADP
admet-2268	75	4	optimization	optimization	NOUN
admet-2268	75	5	of	of	ADP
admet-2268	75	6	dual	dual	ADJ
admet-2268	75	7	drug	drug	NOUN
admet-2268	75	8	-	-	PUNCT
admet-2268	75	9	loaded	load	VERB
admet-2268	75	10	transferosomes	transferosome	NOUN
admet-2268	75	11	to	to	PART
admet-2268	75	12	find	find	VERB
admet-2268	75	13	the	the	DET
admet-2268	75	14	best	good	ADJ
admet-2268	75	15	dual	dual	ADJ
admet-2268	75	16	drug	drug	NOUN
admet-2268	75	17	-	-	PUNCT
admet-2268	75	18	loaded	load	VERB
admet-2268	75	19	nanoparticles	nanoparticle	NOUN
admet-2268	75	20	,	,	PUNCT
admet-2268	75	21	a	a	DET
admet-2268	75	22	box	box	NOUN
admet-2268	75	23	-	-	PUNCT
admet-2268	75	24	behnken	behnken	VERB
admet-2268	75	25	design	design	NOUN
admet-2268	75	26	(	(	PUNCT
admet-2268	75	27	trial	trial	NOUN
admet-2268	75	28	version	version	NOUN
admet-2268	75	29	,	,	PUNCT
admet-2268	75	30	design	design	NOUN
admet-2268	75	31	expert	expert	NOUN
admet-2268	75	32	software	software	NOUN
admet-2268	75	33	,	,	PUNCT
admet-2268	75	34	statease	statease	PROPN
admet-2268	75	35	®	®	PROPN
admet-2268	75	36	,	,	PUNCT
admet-2268	75	37	minneapolis	minneapolis	PROPN
admet-2268	75	38	,	,	PUNCT
admet-2268	75	39	minnesota	minnesota	PROPN
admet-2268	75	40	)	)	PUNCT
admet-2268	75	41	was	be	AUX
admet-2268	75	42	used	use	VERB
admet-2268	75	43	to	to	PART
admet-2268	75	44	investigate	investigate	VERB
admet-2268	75	45	how	how	SCONJ
admet-2268	75	46	independent	independent	ADJ
admet-2268	75	47	variables	variable	NOUN
admet-2268	75	48	(	(	PUNCT
admet-2268	75	49	a	a	DET
admet-2268	75	50	amount	amount	NOUN
admet-2268	75	51	of	of	ADP
admet-2268	75	52	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	75	53	,	,	PUNCT
admet-2268	75	54	b	b	NOUN
admet-2268	75	55	amount	amount	NOUN
admet-2268	75	56	of	of	ADP
admet-2268	75	57	edge	edge	NOUN
admet-2268	75	58	activator	activator	NOUN
admet-2268	75	59	and	and	CCONJ
admet-2268	75	60	c	c	NOUN
admet-2268	75	61	sonication	sonication	NOUN
admet-2268	75	62	cycles	cycle	NOUN
admet-2268	75	63	time	time	NOUN
admet-2268	75	64	)	)	PUNCT
admet-2268	75	65	affected	affect	VERB
admet-2268	75	66	dependent	dependent	ADJ
admet-2268	75	67	variables	variable	NOUN
admet-2268	75	68	(	(	PUNCT
admet-2268	75	69	particle	particle	NOUN
admet-2268	75	70	size	size	NOUN
admet-2268	75	71	and	and	CCONJ
admet-2268	75	72	entrapment	entrapment	ADJ
admet-2268	75	73	efficiency	efficiency	NOUN
admet-2268	75	74	)	)	PUNCT
admet-2268	75	75	.	.	PUNCT
admet-2268	76	1	levels	level	NOUN
admet-2268	76	2	of	of	ADP
admet-2268	76	3	independent	independent	ADJ
admet-2268	76	4	variables	variable	NOUN
admet-2268	76	5	were	be	AUX
admet-2268	76	6	decided	decide	VERB
admet-2268	76	7	according	accord	VERB
admet-2268	76	8	to	to	ADP
admet-2268	76	9	preliminary	preliminary	ADJ
admet-2268	76	10	trials	trial	NOUN
admet-2268	76	11	done	do	VERB
admet-2268	76	12	.	.	PUNCT
admet-2268	77	1	the	the	DET
admet-2268	77	2	effect	effect	NOUN
admet-2268	77	3	of	of	ADP
admet-2268	77	4	independent	independent	ADJ
admet-2268	77	5	factors	factor	NOUN
admet-2268	77	6	on	on	ADP
admet-2268	77	7	dependent	dependent	ADJ
admet-2268	77	8	factors	factor	NOUN
admet-2268	77	9	was	be	AUX
admet-2268	77	10	optimized	optimize	VERB
admet-2268	77	11	by	by	ADP
admet-2268	77	12	using	use	VERB
admet-2268	77	13	a	a	DET
admet-2268	77	14	3	3	NUM
admet-2268	77	15	-	-	PUNCT
admet-2268	77	16	level	level	NOUN
admet-2268	77	17	factorial	factorial	NOUN
admet-2268	77	18	design	design	NOUN
admet-2268	77	19	.	.	PUNCT
admet-2268	78	1	statistical	statistical	ADJ
admet-2268	78	2	tests	test	NOUN
admet-2268	78	3	,	,	PUNCT
admet-2268	78	4	including	include	VERB
admet-2268	78	5	one	one	NUM
admet-2268	78	6	-	-	PUNCT
admet-2268	78	7	way	way	NOUN
admet-2268	78	8	analysis	analysis	NOUN
admet-2268	78	9	of	of	ADP
admet-2268	78	10	variance	variance	NOUN
admet-2268	78	11	(	(	PUNCT
admet-2268	78	12	anova	anova	PROPN
admet-2268	78	13	)	)	PUNCT
admet-2268	78	14	followed	follow	VERB
admet-2268	78	15	by	by	ADP
admet-2268	78	16	bonferroni	bonferroni	NOUN
admet-2268	78	17	multiple	multiple	ADJ
admet-2268	78	18	comparison	comparison	NOUN
admet-2268	78	19	test	test	NOUN
admet-2268	78	20	,	,	PUNCT
admet-2268	78	21	goodness	goodness	NOUN
admet-2268	78	22	-	-	PUNCT
admet-2268	78	23	of	of	ADP
admet-2268	78	24	-	-	PUNCT
admet-2268	78	25	fit	fit	NOUN
admet-2268	78	26	tests	test	NOUN
admet-2268	78	27	,	,	PUNCT
admet-2268	78	28	and	and	CCONJ
admet-2268	78	29	regression	regression	NOUN
admet-2268	78	30	coefficient	coefficient	NOUN
admet-2268	78	31	(	(	PUNCT
admet-2268	78	32	r2	r2	NOUN
admet-2268	78	33	)	)	PUNCT
admet-2268	78	34	tests	test	NOUN
admet-2268	78	35	,	,	PUNCT
admet-2268	78	36	were	be	AUX
admet-2268	78	37	used	use	VERB
admet-2268	78	38	to	to	PART
admet-2268	78	39	ascertain	ascertain	VERB
admet-2268	78	40	the	the	DET
admet-2268	78	41	relevance	relevance	NOUN
admet-2268	78	42	of	of	ADP
admet-2268	78	43	the	the	DET
admet-2268	78	44	applied	apply	VERB
admet-2268	78	45	model	model	NOUN
admet-2268	78	46	.	.	PUNCT
admet-2268	79	1	mathematical	mathematical	ADJ
admet-2268	79	2	model	model	NOUN
admet-2268	79	3	in	in	ADP
admet-2268	79	4	order	order	NOUN
admet-2268	79	5	to	to	PART
admet-2268	79	6	accurately	accurately	ADV
admet-2268	79	7	assess	assess	VERB
admet-2268	79	8	the	the	DET
admet-2268	79	9	effects	effect	NOUN
admet-2268	79	10	of	of	ADP
admet-2268	79	11	independent	independent	ADJ
admet-2268	79	12	factors	factor	NOUN
admet-2268	79	13	on	on	ADP
admet-2268	79	14	dependent	dependent	ADJ
admet-2268	79	15	variables	variable	NOUN
admet-2268	79	16	,	,	PUNCT
admet-2268	79	17	a	a	DET
admet-2268	79	18	nonlinear	nonlinear	ADJ
admet-2268	79	19	quadratic	quadratic	ADJ
admet-2268	79	20	polynomial	polynomial	ADJ
admet-2268	79	21	model	model	NOUN
admet-2268	79	22	was	be	AUX
admet-2268	79	23	developed	develop	VERB
admet-2268	79	24	using	use	VERB
admet-2268	79	25	the	the	DET
admet-2268	79	26	design	design	NOUN
admet-2268	79	27	expert	expert	NOUN
admet-2268	79	28	software	software	NOUN
admet-2268	79	29	trial	trial	NOUN
admet-2268	79	30	version	version	NOUN
admet-2268	79	31	(	(	PUNCT
admet-2268	79	32	stat	stat	NOUN
admet-2268	79	33	-	-	PUNCT
admet-2268	79	34	ease	ease	NOUN
admet-2268	79	35	,	,	PUNCT
admet-2268	79	36	inc	inc	PROPN
admet-2268	79	37	.	.	PROPN
admet-2268	79	38	,	,	PUNCT
admet-2268	79	39	minneapolis	minneapolis	PROPN
admet-2268	79	40	,	,	PUNCT
admet-2268	79	41	mn	mn	PROPN
admet-2268	79	42	)	)	PUNCT
admet-2268	79	43	.	.	PUNCT
admet-2268	80	1	the	the	DET
admet-2268	80	2	nonlinear	nonlinear	ADJ
admet-2268	80	3	quadratic	quadratic	ADJ
admet-2268	80	4	polynomial	polynomial	ADJ
admet-2268	80	5	model	model	NOUN
admet-2268	80	6	was	be	AUX
admet-2268	80	7	developed	develop	VERB
admet-2268	80	8	considering	consider	VERB
admet-2268	80	9	the	the	DET
admet-2268	80	10	replicated	replicate	VERB
admet-2268	80	11	center	center	NOUN
admet-2268	80	12	points	point	NOUN
admet-2268	80	13	and	and	CCONJ
admet-2268	80	14	points	point	NOUN
admet-2268	80	15	placed	place	VERB
admet-2268	80	16	on	on	ADP
admet-2268	80	17	the	the	DET
admet-2268	80	18	multidimensional	multidimensional	ADJ
admet-2268	80	19	cube	cube	NOUN
admet-2268	80	20	's	's	PART
admet-2268	80	21	midpoints	midpoint	NOUN
admet-2268	80	22	(	(	PUNCT
admet-2268	80	23	equation	equation	NOUN
admet-2268	80	24	1	1	NUM
admet-2268	80	25	)	)	PUNCT
admet-2268	80	26	.	.	PUNCT
admet-2268	81	1	to	to	PART
admet-2268	81	2	optimize	optimize	VERB
admet-2268	81	3	the	the	DET
admet-2268	81	4	formulation	formulation	NOUN
admet-2268	81	5	,	,	PUNCT
admet-2268	81	6	the	the	DET
admet-2268	81	7	center	center	NOUN
admet-2268	81	8	point	point	NOUN
admet-2268	81	9	region	region	NOUN
admet-2268	81	10	of	of	ADP
admet-2268	81	11	the	the	DET
admet-2268	81	12	multidimensional	multidimensional	ADJ
admet-2268	81	13	cube	cube	NOUN
admet-2268	81	14	was	be	AUX
admet-2268	81	15	deemed	deem	VERB
admet-2268	81	16	significant	significant	ADJ
admet-2268	81	17	for	for	ADP
admet-2268	81	18	assessing	assess	VERB
admet-2268	81	19	the	the	DET
admet-2268	81	20	effect	effect	NOUN
admet-2268	81	21	of	of	ADP
admet-2268	81	22	formulation	formulation	NOUN
admet-2268	81	23	variables	variable	NOUN
admet-2268	81	24	.	.	PUNCT
admet-2268	82	1	yi	yi	NOUN
admet-2268	83	1	=	=	PUNCT
admet-2268	83	2	β0	β0	PROPN
admet-2268	84	1	+	+	CCONJ
admet-2268	84	2	β1a	β1a	PUNCT
admet-2268	84	3	+	+	CCONJ
admet-2268	84	4	β2b	β2b	PUNCT
admet-2268	84	5	+	+	NUM
admet-2268	84	6	β3c	β3c	NOUN
admet-2268	84	7	+	+	NUM
admet-2268	84	8	β4ab	β4ab	PUNCT
admet-2268	84	9	+	+	CCONJ
admet-2268	84	10	β5ac	β5ac	PUNCT
admet-2268	84	11	+	+	CCONJ
admet-2268	84	12	β6bc	β6bc	PUNCT
admet-2268	85	1	+	+	CCONJ
admet-2268	85	2	β7a2	β7a2	PUNCT
admet-2268	86	1	+	+	CCONJ
admet-2268	86	2	β8b2	β8b2	X
admet-2268	87	1	+	+	CCONJ
admet-2268	87	2	β9c2	β9c2	PUNCT
admet-2268	87	3	(	(	PUNCT
admet-2268	87	4	1	1	X
admet-2268	87	5	)	)	PUNCT
admet-2268	87	6	where	where	SCONJ
admet-2268	87	7	yi	yi	PROPN
admet-2268	87	8	is	be	AUX
admet-2268	87	9	the	the	DET
admet-2268	87	10	dependent	dependent	ADJ
admet-2268	87	11	variable	variable	NOUN
admet-2268	87	12	related	relate	VERB
admet-2268	87	13	to	to	ADP
admet-2268	87	14	independent	independent	ADJ
admet-2268	87	15	variables	variable	NOUN
admet-2268	87	16	a	a	DET
admet-2268	87	17	,	,	PUNCT
admet-2268	87	18	b	b	PROPN
admet-2268	87	19	and	and	CCONJ
admet-2268	87	20	c	c	PROPN
admet-2268	87	21	(	(	PUNCT
admet-2268	87	22	table	table	NOUN
admet-2268	87	23	1	1	NUM
admet-2268	87	24	)	)	PUNCT
admet-2268	87	25	.	.	PUNCT
admet-2268	88	1	the	the	DET
admet-2268	88	2	impact	impact	NOUN
admet-2268	88	3	of	of	ADP
admet-2268	88	4	the	the	DET
admet-2268	88	5	independent	independent	ADJ
admet-2268	88	6	variables	variable	NOUN
admet-2268	88	7	was	be	AUX
admet-2268	88	8	assessed	assess	VERB
admet-2268	88	9	on	on	ADP
admet-2268	88	10	the	the	DET
admet-2268	88	11	dependent	dependent	ADJ
admet-2268	88	12	factors	factor	NOUN
admet-2268	88	13	y1	y1	INTJ
admet-2268	88	14	(	(	PUNCT
admet-2268	88	15	particle	particle	NOUN
admet-2268	88	16	size	size	NOUN
admet-2268	88	17	)	)	PUNCT
admet-2268	88	18	,	,	PUNCT
admet-2268	88	19	y2	y2	INTJ
admet-2268	88	20	(	(	PUNCT
admet-2268	88	21	entrapment	entrapment	ADJ
admet-2268	88	22	efficiency	efficiency	NOUN
admet-2268	88	23	of	of	ADP
admet-2268	88	24	berberine	berberine	NOUN
admet-2268	88	25	hcl	hcl	PROPN
admet-2268	88	26	)	)	PUNCT
admet-2268	88	27	,	,	PUNCT
admet-2268	88	28	and	and	CCONJ
admet-2268	88	29	y3	y3	NOUN
admet-2268	88	30	(	(	PUNCT
admet-2268	88	31	entrapment	entrapment	ADJ
admet-2268	88	32	efficiency	efficiency	NOUN
admet-2268	88	33	of	of	ADP
admet-2268	88	34	diacerein	diacerein	ADJ
admet-2268	88	35	)	)	PUNCT
admet-2268	88	36	.	.	PUNCT
admet-2268	89	1	the	the	DET
admet-2268	89	2	statistical	statistical	ADJ
admet-2268	89	3	design	design	NOUN
admet-2268	89	4	was	be	AUX
admet-2268	89	5	validated	validate	VERB
admet-2268	89	6	by	by	ADP
admet-2268	89	7	the	the	DET
admet-2268	89	8	significant	significant	ADJ
admet-2268	89	9	responses	response	NOUN
admet-2268	89	10	depicted	depict	VERB
admet-2268	89	11	by	by	ADP
admet-2268	89	12	the	the	DET
admet-2268	89	13	polynomial	polynomial	ADJ
admet-2268	89	14	equations	equation	NOUN
admet-2268	89	15	,	,	PUNCT
admet-2268	89	16	and	and	CCONJ
admet-2268	89	17	the	the	DET
admet-2268	89	18	model	model	NOUN
admet-2268	89	19	optimization	optimization	NOUN
admet-2268	89	20	and	and	CCONJ
admet-2268	89	21	validation	validation	NOUN
admet-2268	89	22	were	be	AUX
admet-2268	89	23	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	PROPN
admet-2268	89	24	s.	s.	PROPN
admet-2268	89	25	singh	singh	PROPN
admet-2268	89	26	and	and	CCONJ
admet-2268	89	27	r.	r.	PROPN
admet-2268	89	28	awasthi	awasthi	PROPN
admet-2268	89	29	admet	admet	PROPN
admet-2268	89	30	&	&	CCONJ
admet-2268	89	31	dmpk	dmpk	PROPN
admet-2268	89	32	12(3	12(3	PROPN
admet-2268	89	33	)	)	PUNCT
admet-2268	89	34	(	(	PUNCT
admet-2268	89	35	2024	2024	NUM
admet-2268	89	36	)	)	PUNCT
admet-2268	89	37	553	553	NUM
admet-2268	89	38	-	-	SYM
admet-2268	89	39	580	580	NUM
admet-2268	89	40	556	556	NUM
admet-2268	89	41	considered	consider	VERB
admet-2268	89	42	by	by	ADP
admet-2268	89	43	determining	determine	VERB
admet-2268	89	44	the	the	DET
admet-2268	89	45	anova	anova	X
admet-2268	89	46	(	(	PUNCT
admet-2268	89	47	f	f	NOUN
admet-2268	89	48	-	-	PUNCT
admet-2268	89	49	value	value	NOUN
admet-2268	89	50	)	)	PUNCT
admet-2268	89	51	and	and	CCONJ
admet-2268	89	52	p	p	X
admet-2268	89	53	<	<	X
admet-2268	89	54	0.05	0.05	NUM
admet-2268	89	55	.	.	PUNCT
admet-2268	90	1	moreover	moreover	ADV
admet-2268	90	2	,	,	PUNCT
admet-2268	90	3	the	the	DET
admet-2268	90	4	counterplots	counterplot	NOUN
admet-2268	90	5	and	and	CCONJ
admet-2268	90	6	3d	3d	NUM
admet-2268	90	7	response	response	NOUN
admet-2268	90	8	surface	surface	NOUN
admet-2268	90	9	were	be	AUX
admet-2268	90	10	plotted	plot	VERB
admet-2268	90	11	to	to	PART
admet-2268	90	12	establish	establish	VERB
admet-2268	90	13	the	the	DET
admet-2268	90	14	relationship	relationship	NOUN
admet-2268	90	15	and	and	CCONJ
admet-2268	90	16	interaction	interaction	NOUN
admet-2268	90	17	among	among	ADP
admet-2268	90	18	the	the	DET
admet-2268	90	19	variables	variable	NOUN
admet-2268	90	20	and	and	CCONJ
admet-2268	90	21	responses	response	NOUN
admet-2268	90	22	.	.	PUNCT
admet-2268	91	1	the	the	DET
admet-2268	91	2	difference	difference	NOUN
admet-2268	91	3	between	between	ADP
admet-2268	91	4	predicted	predict	VERB
admet-2268	91	5	and	and	CCONJ
admet-2268	91	6	actual	actual	ADJ
admet-2268	91	7	values	value	NOUN
admet-2268	91	8	was	be	AUX
admet-2268	91	9	determined	determine	VERB
admet-2268	91	10	by	by	ADP
admet-2268	91	11	optimizing	optimize	VERB
admet-2268	91	12	extra	extra	ADJ
admet-2268	91	13	checkpoints	checkpoint	NOUN
admet-2268	91	14	.	.	PUNCT
admet-2268	92	1	as	as	ADP
admet-2268	92	2	per	per	ADP
admet-2268	92	3	the	the	DET
admet-2268	92	4	number	number	NOUN
admet-2268	92	5	of	of	ADP
admet-2268	92	6	runs	run	NOUN
admet-2268	92	7	received	receive	VERB
admet-2268	92	8	by	by	ADP
admet-2268	92	9	the	the	DET
admet-2268	92	10	box	box	NOUN
admet-2268	92	11	-	-	PUNCT
admet-2268	92	12	behnken	behnken	VERB
admet-2268	92	13	design	design	NOUN
admet-2268	92	14	,	,	PUNCT
admet-2268	92	15	the	the	DET
admet-2268	92	16	formulations	formulation	NOUN
admet-2268	92	17	were	be	AUX
admet-2268	92	18	prepared	prepare	VERB
admet-2268	92	19	and	and	CCONJ
admet-2268	92	20	evaluated	evaluate	VERB
admet-2268	92	21	[	[	X
admet-2268	92	22	12	12	NUM
admet-2268	92	23	]	]	PUNCT
admet-2268	92	24	.	.	PUNCT
admet-2268	93	1	table	table	NOUN
admet-2268	93	2	1	1	NUM
admet-2268	93	3	.	.	PUNCT
admet-2268	93	4	box	box	NOUN
admet-2268	93	5	-	-	PUNCT
admet-2268	93	6	behnken	behnken	VERB
admet-2268	93	7	design	design	NOUN
admet-2268	93	8	with	with	ADP
admet-2268	93	9	the	the	DET
admet-2268	93	10	levels	level	NOUN
admet-2268	93	11	of	of	ADP
admet-2268	93	12	independent	independent	ADJ
admet-2268	93	13	variables	variable	NOUN
admet-2268	93	14	used	use	VERB
admet-2268	93	15	to	to	PART
admet-2268	93	16	formulate	formulate	VERB
admet-2268	93	17	berberine	berberine	NOUN
admet-2268	93	18	hcl	hcl	PROPN
admet-2268	93	19	and	and	CCONJ
admet-2268	93	20	diacereinloaded	diacereinloade	VERB
admet-2268	93	21	dual	dual	ADJ
admet-2268	93	22	delivery	delivery	NOUN
admet-2268	93	23	transferosomes	transferosome	NOUN
admet-2268	93	24	.	.	PUNCT
admet-2268	94	1	formulation	formulation	NOUN
admet-2268	94	2	code	code	NOUN
admet-2268	94	3	independent	independent	ADJ
admet-2268	94	4	variable	variable	NOUN
admet-2268	94	5	a	a	DET
admet-2268	94	6	(	(	PUNCT
admet-2268	94	7	amount	amount	NOUN
admet-2268	94	8	of	of	ADP
admet-2268	94	9	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	94	10	)	)	PUNCT
admet-2268	94	11	b	b	NOUN
admet-2268	94	12	(	(	PUNCT
admet-2268	94	13	amount	amount	NOUN
admet-2268	94	14	of	of	ADP
admet-2268	94	15	sodium	sodium	NOUN
admet-2268	94	16	deoxycholate	deoxycholate	NOUN
admet-2268	94	17	)	)	PUNCT
admet-2268	94	18	c	c	NOUN
admet-2268	94	19	(	(	PUNCT
admet-2268	94	20	sonication	sonication	NOUN
admet-2268	94	21	cycle	cycle	NOUN
admet-2268	94	22	time	time	NOUN
admet-2268	94	23	)	)	PUNCT
admet-2268	94	24	ddt-1	ddt-1	ADV
admet-2268	94	25	1	1	NUM
admet-2268	94	26	-1	-1	SYM
admet-2268	94	27	0	0	NUM
admet-2268	94	28	ddt-2	ddt-2	NUM
admet-2268	94	29	0	0	NUM
admet-2268	94	30	-1	-1	CCONJ
admet-2268	94	31	-1	-1	CCONJ
admet-2268	94	32	ddt-3	ddt-3	ADV
admet-2268	94	33	0	0	NUM
admet-2268	94	34	1	1	NUM
admet-2268	94	35	1	1	NUM
admet-2268	94	36	ddt-4	ddt-4	NUM
admet-2268	94	37	0	0	NUM
admet-2268	94	38	-1	-1	SYM
admet-2268	94	39	1	1	NUM
admet-2268	94	40	ddt-5	ddt-5	NUM
admet-2268	94	41	-1	-1	SYM
admet-2268	95	1	1	1	NUM
admet-2268	95	2	0	0	NUM
admet-2268	95	3	ddt-6	ddt-6	NUM
admet-2268	95	4	1	1	NUM
admet-2268	95	5	1	1	NUM
admet-2268	95	6	0	0	NUM
admet-2268	95	7	ddt-7	ddt-7	NUM
admet-2268	95	8	1	1	NUM
admet-2268	95	9	0	0	NUM
admet-2268	95	10	-1	-1	NOUN
admet-2268	95	11	ddt-8	ddt-8	NUM
admet-2268	95	12	-1	-1	ADP
admet-2268	95	13	0	0	NUM
admet-2268	96	1	-1	-1	PUNCT
admet-2268	96	2	ddt-9	ddt-9	NUM
admet-2268	96	3	0	0	NUM
admet-2268	96	4	1	1	NUM
admet-2268	96	5	-1	-1	NOUN
admet-2268	96	6	ddt-10	ddt-10	VERB
admet-2268	96	7	0	0	NUM
admet-2268	96	8	0	0	NUM
admet-2268	96	9	0	0	NUM
admet-2268	96	10	ddt-11	ddt-11	NUM
admet-2268	96	11	-1	-1	NOUN
admet-2268	96	12	0	0	NUM
admet-2268	96	13	1	1	NUM
admet-2268	96	14	ddt-12	ddt-12	NOUN
admet-2268	96	15	1	1	NUM
admet-2268	96	16	0	0	NUM
admet-2268	96	17	1	1	NUM
admet-2268	96	18	ddt-13	ddt-13	NOUN
admet-2268	96	19	-1	-1	PUNCT
admet-2268	96	20	-1	-1	PUNCT
admet-2268	97	1	0	0	PUNCT
admet-2268	97	2	codes	code	NOUN
admet-2268	97	3	for	for	ADP
admet-2268	97	4	different	different	ADJ
admet-2268	97	5	levels	level	NOUN
admet-2268	97	6	of	of	ADP
admet-2268	97	7	independent	independent	ADJ
admet-2268	97	8	variables	variable	NOUN
admet-2268	97	9	values	value	NOUN
admet-2268	97	10	for	for	ADP
admet-2268	97	11	independent	independent	ADJ
admet-2268	97	12	variables	variable	NOUN
admet-2268	97	13	amount	amount	NOUN
admet-2268	97	14	of	of	ADP
admet-2268	97	15	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	97	16	,	,	PUNCT
admet-2268	97	17	mg	mg	PROPN
admet-2268	97	18	amount	amount	NOUN
admet-2268	97	19	of	of	ADP
admet-2268	97	20	sodium	sodium	NOUN
admet-2268	97	21	deoxycholate	deoxycholate	VERB
admet-2268	97	22	,	,	PUNCT
admet-2268	97	23	mg	mg	PROPN
admet-2268	97	24	sonication	sonication	NOUN
admet-2268	97	25	cycle	cycle	NOUN
admet-2268	97	26	time	time	NOUN
admet-2268	97	27	,	,	PUNCT
admet-2268	97	28	min	min	NOUN
admet-2268	97	29	-1	-1	PROPN
admet-2268	98	1	75	75	NUM
admet-2268	98	2	5	5	NUM
admet-2268	98	3	1	1	NUM
admet-2268	98	4	-0.5	-0.5	NUM
admet-2268	98	5	80	80	NUM
admet-2268	98	6	10	10	NUM
admet-2268	98	7	2	2	NUM
admet-2268	98	8	0	0	NUM
admet-2268	98	9	85	85	NUM
admet-2268	98	10	15	15	NUM
admet-2268	98	11	3	3	NUM
admet-2268	98	12	0.5	0.5	NUM
admet-2268	98	13	90	90	NUM
admet-2268	98	14	20	20	NUM
admet-2268	98	15	4	4	NUM
admet-2268	98	16	+1	+1	NUM
admet-2268	98	17	95	95	NUM
admet-2268	98	18	25	25	NUM
admet-2268	98	19	5	5	NUM
admet-2268	98	20	dependent	dependent	ADJ
admet-2268	98	21	variables	variable	NOUN
admet-2268	98	22	:	:	PUNCT
admet-2268	98	23	y1	y1	NOUN
admet-2268	98	24	particle	particle	NOUN
admet-2268	98	25	size	size	NOUN
admet-2268	98	26	(	(	PUNCT
admet-2268	98	27	minimum	minimum	NOUN
admet-2268	98	28	)	)	PUNCT
admet-2268	98	29	;	;	PUNCT
admet-2268	98	30	y2	y2	PROPN
admet-2268	98	31	entrapment	entrapment	ADJ
admet-2268	98	32	efficiency	efficiency	NOUN
admet-2268	98	33	of	of	ADP
admet-2268	98	34	berberine	berberine	NOUN
admet-2268	98	35	hcl	hcl	PROPN
admet-2268	98	36	and	and	CCONJ
admet-2268	98	37	y3	y3	VERB
admet-2268	98	38	entrapment	entrapment	ADJ
admet-2268	98	39	efficiency	efficiency	NOUN
admet-2268	98	40	of	of	ADP
admet-2268	98	41	diacerein	diacerein	ADJ
admet-2268	98	42	(	(	PUNCT
admet-2268	98	43	maximum	maximum	ADJ
admet-2268	98	44	)	)	PUNCT
admet-2268	98	45	characterization	characterization	NOUN
admet-2268	98	46	of	of	ADP
admet-2268	98	47	dual	dual	ADJ
admet-2268	98	48	delivery	delivery	NOUN
admet-2268	98	49	transferosomes	transferosome	NOUN
admet-2268	98	50	drug	drug	NOUN
admet-2268	98	51	loading	loading	NOUN
admet-2268	98	52	and	and	CCONJ
admet-2268	98	53	encapsulation	encapsulation	NOUN
admet-2268	98	54	efficiency	efficiency	NOUN
admet-2268	98	55	for	for	ADP
admet-2268	98	56	the	the	DET
admet-2268	98	57	estimation	estimation	NOUN
admet-2268	98	58	of	of	ADP
admet-2268	98	59	drug	drug	NOUN
admet-2268	98	60	loading	loading	NOUN
admet-2268	98	61	and	and	CCONJ
admet-2268	98	62	entrapment	entrapment	ADJ
admet-2268	98	63	efficiency	efficiency	NOUN
admet-2268	98	64	,	,	PUNCT
admet-2268	98	65	5	5	NUM
admet-2268	98	66	ml	ml	NOUN
admet-2268	98	67	of	of	ADP
admet-2268	98	68	sample	sample	NOUN
admet-2268	98	69	was	be	AUX
admet-2268	98	70	dispersed	disperse	VERB
admet-2268	98	71	into	into	ADP
admet-2268	98	72	5	5	NUM
admet-2268	98	73	ml	ml	NOUN
admet-2268	98	74	of	of	ADP
admet-2268	98	75	pbs	pbs	PROPN
admet-2268	98	76	(	(	PUNCT
admet-2268	98	77	ph	ph	NOUN
admet-2268	98	78	7.4	7.4	NUM
admet-2268	98	79	)	)	PUNCT
admet-2268	98	80	solution	solution	NOUN
admet-2268	98	81	and	and	CCONJ
admet-2268	98	82	centrifuged	centrifuged	PROPN
admet-2268	98	83	(	(	PUNCT
admet-2268	98	84	remi	remi	PROPN
admet-2268	98	85	c-24	c-24	PROPN
admet-2268	98	86	plus	plus	CCONJ
admet-2268	98	87	,	,	PUNCT
admet-2268	98	88	mumbai	mumbai	PROPN
admet-2268	98	89	,	,	PUNCT
admet-2268	98	90	india	india	PROPN
admet-2268	98	91	)	)	PUNCT
admet-2268	98	92	at	at	ADP
admet-2268	98	93	10000	10000	NUM
admet-2268	98	94	rpm	rpm	NOUN
admet-2268	98	95	for	for	ADP
admet-2268	98	96	30	30	NUM
admet-2268	98	97	min	min	NOUN
admet-2268	98	98	at	at	ADP
admet-2268	98	99	4	4	NUM
admet-2268	98	100	°	°	NOUN
admet-2268	98	101	c	c	NOUN
admet-2268	98	102	.	.	PUNCT
admet-2268	99	1	after	after	ADP
admet-2268	99	2	centrifugation	centrifugation	NOUN
admet-2268	99	3	,	,	PUNCT
admet-2268	99	4	the	the	DET
admet-2268	99	5	supernatant	supernatant	NOUN
admet-2268	99	6	was	be	AUX
admet-2268	99	7	collected	collect	VERB
admet-2268	99	8	.	.	PUNCT
admet-2268	100	1	the	the	DET
admet-2268	100	2	free	free	PROPN
admet-2268	100	3	berberine	berberine	NOUN
admet-2268	100	4	hcl	hcl	PROPN
admet-2268	100	5	and	and	CCONJ
admet-2268	100	6	diacerein	diacerein	ADJ
admet-2268	100	7	were	be	AUX
admet-2268	100	8	analyzed	analyze	VERB
admet-2268	100	9	using	use	VERB
admet-2268	100	10	a	a	DET
admet-2268	100	11	uv	uv	NOUN
admet-2268	100	12	spectrophotometer	spectrophotometer	NOUN
admet-2268	100	13	(	(	PUNCT
admet-2268	100	14	uv-1900	uv-1900	PROPN
admet-2268	100	15	shimadzu	shimadzu	NOUN
admet-2268	100	16	,	,	PUNCT
admet-2268	100	17	japan	japan	PROPN
admet-2268	100	18	)	)	PUNCT
admet-2268	100	19	at	at	ADP
admet-2268	100	20	340	340	NUM
admet-2268	100	21	and	and	CCONJ
admet-2268	100	22	258	258	NUM
admet-2268	100	23	nm	nm	NOUN
admet-2268	100	24	,	,	PUNCT
admet-2268	100	25	respectively	respectively	ADV
admet-2268	100	26	.	.	PUNCT
admet-2268	101	1	the	the	DET
admet-2268	101	2	drug	drug	NOUN
admet-2268	101	3	loading	loading	NOUN
admet-2268	101	4	and	and	CCONJ
admet-2268	101	5	entrapment	entrapment	ADJ
admet-2268	101	6	efficiency	efficiency	NOUN
admet-2268	101	7	were	be	AUX
admet-2268	101	8	calculated	calculate	VERB
admet-2268	101	9	using	use	VERB
admet-2268	101	10	equations	equation	NOUN
admet-2268	101	11	(	(	PUNCT
admet-2268	101	12	2	2	NUM
admet-2268	101	13	)	)	PUNCT
admet-2268	101	14	and	and	CCONJ
admet-2268	101	15	(	(	PUNCT
admet-2268	101	16	3	3	X
admet-2268	101	17	)	)	PUNCT
admet-2268	102	1	[	[	X
admet-2268	102	2	18,20	18,20	X
admet-2268	102	3	]	]	X
admet-2268	102	4	:	:	PUNCT
admet-2268	102	5	theoretical	theoretical	ADJ
admet-2268	102	6	amount	amount	NOUN
admet-2268	102	7	of	of	ADP
admet-2268	102	8	drug	drug	NOUN
admet-2268	102	9	–	–	PUNCT
admet-2268	102	10	unentrapped	unentrappe	VERB
admet-2268	102	11	drug	drug	NOUN
admet-2268	102	12	drug	drug	NOUN
admet-2268	102	13	loading	loading	NOUN
admet-2268	102	14	,	,	PUNCT
admet-2268	102	15	%	%	NOUN
admet-2268	102	16	=	=	SYM
admet-2268	102	17	100	100	NUM
admet-2268	102	18	amount	amount	NOUN
admet-2268	102	19	of	of	ADP
admet-2268	102	20	drugloaded	drugloade	VERB
admet-2268	102	21	transferosomes	transferosome	NOUN
admet-2268	102	22	(	(	PUNCT
admet-2268	102	23	2	2	NUM
admet-2268	102	24	)	)	PUNCT
admet-2268	102	25	%	%	NOUN
admet-2268	102	26	theoretical	theoretical	ADJ
admet-2268	102	27	amount	amount	NOUN
admet-2268	102	28	of	of	ADP
admet-2268	102	29	drug	drug	NOUN
admet-2268	102	30	–	–	PUNCT
admet-2268	102	31	unentrapped	unentrappe	VERB
admet-2268	102	32	drug	drug	NOUN
admet-2268	102	33	entrapment	entrapment	NOUN
admet-2268	102	34	efficiency	efficiency	NOUN
admet-2268	102	35	,	,	PUNCT
admet-2268	102	36	=	=	NOUN
admet-2268	102	37	100	100	NUM
admet-2268	102	38	theoretical	theoretical	ADJ
admet-2268	102	39	amount	amount	NOUN
admet-2268	102	40	of	of	ADP
admet-2268	102	41	drug	drug	NOUN
admet-2268	102	42	(	(	PUNCT
admet-2268	102	43	3	3	NUM
admet-2268	102	44	)	)	PUNCT
admet-2268	102	45	determination	determination	NOUN
admet-2268	102	46	of	of	ADP
admet-2268	102	47	vesicle	vesicle	NOUN
admet-2268	102	48	size	size	NOUN
admet-2268	102	49	,	,	PUNCT
admet-2268	102	50	polydispersity	polydispersity	NOUN
admet-2268	102	51	index	index	NOUN
admet-2268	102	52	,	,	PUNCT
admet-2268	102	53	and	and	CCONJ
admet-2268	102	54	zeta	zeta	PROPN
admet-2268	102	55	potential	potential	NOUN
admet-2268	102	56	the	the	DET
admet-2268	102	57	prepared	prepared	ADJ
admet-2268	102	58	transferosomes	transferosome	NOUN
admet-2268	102	59	were	be	AUX
admet-2268	102	60	diluted	dilute	VERB
admet-2268	102	61	with	with	ADP
admet-2268	102	62	pbs	pbs	PROPN
admet-2268	102	63	(	(	PUNCT
admet-2268	102	64	ph	ph	NOUN
admet-2268	102	65	7.4	7.4	NUM
admet-2268	102	66	)	)	PUNCT
admet-2268	102	67	to	to	PART
admet-2268	102	68	alleviate	alleviate	VERB
admet-2268	102	69	the	the	DET
admet-2268	102	70	opalescence	opalescence	NOUN
admet-2268	102	71	in	in	ADP
admet-2268	102	72	the	the	DET
admet-2268	102	73	solution	solution	NOUN
admet-2268	102	74	.	.	PUNCT
admet-2268	103	1	diluted	dilute	VERB
admet-2268	103	2	transferosomal	transferosomal	ADJ
admet-2268	103	3	solution	solution	NOUN
admet-2268	103	4	(	(	PUNCT
admet-2268	103	5	20	20	NUM
admet-2268	103	6	µl	µl	NOUN
admet-2268	103	7	)	)	PUNCT
admet-2268	103	8	was	be	AUX
admet-2268	103	9	transferred	transfer	VERB
admet-2268	103	10	into	into	ADP
admet-2268	103	11	the	the	DET
admet-2268	103	12	cuvette	cuvette	NOUN
admet-2268	103	13	and	and	CCONJ
admet-2268	103	14	examined	examine	VERB
admet-2268	103	15	for	for	ADP
admet-2268	103	16	particle	particle	NOUN
admet-2268	103	17	size	size	NOUN
admet-2268	103	18	and	and	CCONJ
admet-2268	103	19	polydispersity	polydispersity	NOUN
admet-2268	103	20	index	index	NOUN
admet-2268	103	21	(	(	PUNCT
admet-2268	103	22	pdi	pdi	PROPN
admet-2268	103	23	)	)	PUNCT
admet-2268	103	24	at	at	ADP
admet-2268	103	25	room	room	NOUN
admet-2268	103	26	temperature	temperature	NOUN
admet-2268	103	27	using	use	VERB
admet-2268	103	28	a	a	DET
admet-2268	103	29	malvern	malvern	ADJ
admet-2268	103	30	particle	particle	NOUN
admet-2268	103	31	size	size	NOUN
admet-2268	103	32	analyzer	analyzer	NOUN
admet-2268	103	33	(	(	PUNCT
admet-2268	103	34	en1690	en1690	PROPN
admet-2268	103	35	,	,	PUNCT
admet-2268	103	36	malvern	malvern	PROPN
admet-2268	103	37	instruments	instrument	NOUN
admet-2268	103	38	,	,	PUNCT
admet-2268	103	39	united	united	ADJ
admet-2268	103	40	kingdom	kingdom	PROPN
admet-2268	103	41	)	)	PUNCT
admet-2268	103	42	.	.	PUNCT
admet-2268	104	1	the	the	DET
admet-2268	104	2	average	average	ADJ
admet-2268	104	3	particle	particle	NOUN
admet-2268	104	4	size	size	NOUN
admet-2268	104	5	and	and	CCONJ
admet-2268	104	6	pdi	pdi	NOUN
admet-2268	104	7	values	value	NOUN
admet-2268	104	8	were	be	AUX
admet-2268	104	9	taken	take	VERB
admet-2268	104	10	in	in	ADP
admet-2268	104	11	triplicate	triplicate	NOUN
admet-2268	104	12	at	at	ADP
admet-2268	104	13	a	a	DET
admet-2268	104	14	dissipating	dissipate	VERB
admet-2268	104	15	angle	angle	NOUN
admet-2268	104	16	90	90	NUM
admet-2268	104	17	°	°	NOUN
admet-2268	104	18	.	.	PUNCT
admet-2268	105	1	laser	laser	NOUN
admet-2268	105	2	doppler	doppler	NOUN
admet-2268	105	3	velocimetry	velocimetry	NOUN
admet-2268	105	4	was	be	AUX
admet-2268	105	5	recorded	record	VERB
admet-2268	105	6	to	to	PART
admet-2268	105	7	estimate	estimate	VERB
admet-2268	105	8	the	the	DET
admet-2268	105	9	ζ	ζ	NOUN
admet-2268	105	10	potential	potential	ADJ
admet-2268	105	11	values	value	NOUN
admet-2268	105	12	using	use	VERB
admet-2268	105	13	a	a	DET
admet-2268	105	14	zetasizer	zetasizer	NOUN
admet-2268	105	15	(	(	PUNCT
admet-2268	105	16	litesizer	litesizer	NOUN
admet-2268	105	17	500	500	NUM
admet-2268	105	18	,	,	PUNCT
admet-2268	105	19	antonpaar	antonpaar	NOUN
admet-2268	105	20	,	,	PUNCT
admet-2268	105	21	austria	austria	PROPN
admet-2268	105	22	)	)	PUNCT
admet-2268	106	1	[	[	X
admet-2268	106	2	19	19	NUM
admet-2268	106	3	]	]	PUNCT
admet-2268	106	4	.	.	PUNCT
admet-2268	107	1	admet	admet	PROPN
admet-2268	107	2	&	&	CCONJ
admet-2268	107	3	dmpk	dmpk	PROPN
admet-2268	107	4	12(3	12(3	PROPN
admet-2268	107	5	)	)	PUNCT
admet-2268	107	6	(	(	PUNCT
admet-2268	107	7	2024	2024	NUM
admet-2268	107	8	)	)	PUNCT
admet-2268	107	9	553	553	NUM
admet-2268	107	10	-	-	SYM
admet-2268	107	11	580	580	NUM
admet-2268	107	12	berberine	berberine	NOUN
admet-2268	107	13	hcl	hcl	PROPN
admet-2268	107	14	and	and	CCONJ
admet-2268	107	15	diacerein	diacerein	ADV
admet-2268	107	16	loaded	load	VERB
admet-2268	107	17	dual	dual	ADJ
admet-2268	107	18	delivery	delivery	NOUN
admet-2268	107	19	transferosomes	transferosome	NOUN
admet-2268	107	20	doi	doi	PROPN
admet-2268	107	21	:	:	PUNCT
admet-2268	107	22	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	107	23	557	557	NUM
admet-2268	107	24	fourier	fourier	NOUN
admet-2268	107	25	transform	transform	VERB
admet-2268	107	26	infrared	infrared	ADJ
admet-2268	107	27	analysis	analysis	NOUN
admet-2268	107	28	fourier	fourier	NOUN
admet-2268	107	29	transform	transform	NOUN
admet-2268	107	30	infrared	infrared	ADJ
admet-2268	107	31	(	(	PUNCT
admet-2268	107	32	ftir	ftir	NOUN
admet-2268	107	33	)	)	PUNCT
admet-2268	107	34	study	study	NOUN
admet-2268	107	35	of	of	ADP
admet-2268	107	36	dried	dry	VERB
admet-2268	107	37	berberine	berberine	NOUN
admet-2268	107	38	hcl	hcl	PROPN
admet-2268	107	39	,	,	PUNCT
admet-2268	107	40	diacerein	diacerein	ADJ
admet-2268	107	41	,	,	PUNCT
admet-2268	107	42	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	107	43	,	,	PUNCT
admet-2268	107	44	sodium	sodium	NOUN
admet-2268	107	45	deoxycholate	deoxycholate	VERB
admet-2268	107	46	,	,	PUNCT
admet-2268	107	47	and	and	CCONJ
admet-2268	107	48	drug	drug	NOUN
admet-2268	107	49	-	-	PUNCT
admet-2268	107	50	loaded	load	VERB
admet-2268	107	51	optimized	optimize	VERB
admet-2268	107	52	transferosomes	transferosome	NOUN
admet-2268	107	53	(	(	PUNCT
admet-2268	107	54	formulation	formulation	NOUN
admet-2268	107	55	ddt-10	ddt-10	NOUN
admet-2268	107	56	)	)	PUNCT
admet-2268	107	57	was	be	AUX
admet-2268	107	58	carried	carry	VERB
admet-2268	107	59	out	out	ADP
admet-2268	107	60	by	by	ADP
admet-2268	107	61	the	the	DET
admet-2268	107	62	kbr	kbr	PROPN
admet-2268	107	63	disk	disk	NOUN
admet-2268	107	64	method	method	NOUN
admet-2268	107	65	using	use	VERB
admet-2268	107	66	a	a	DET
admet-2268	107	67	fourier	fourier	NOUN
admet-2268	107	68	transform	transform	NOUN
admet-2268	107	69	infrared	infrared	ADJ
admet-2268	107	70	spectrophotometer	spectrophotometer	NOUN
admet-2268	107	71	(	(	PUNCT
admet-2268	107	72	frontier	frontier	NOUN
admet-2268	107	73	ft	ft	PROPN
admet-2268	107	74	-	-	PUNCT
admet-2268	107	75	ir	ir	PROPN
admet-2268	107	76	/	/	SYM
admet-2268	107	77	fir	fir	NOUN
admet-2268	107	78	,	,	PUNCT
admet-2268	107	79	perkinelmer	perkinelmer	NOUN
admet-2268	107	80	,	,	PUNCT
admet-2268	107	81	norwalk	norwalk	NOUN
admet-2268	107	82	,	,	PUNCT
admet-2268	107	83	usa	usa	PROPN
admet-2268	107	84	)	)	PUNCT
admet-2268	107	85	.	.	PUNCT
admet-2268	108	1	the	the	DET
admet-2268	108	2	pellets	pellet	NOUN
admet-2268	108	3	were	be	AUX
admet-2268	108	4	prepared	prepare	VERB
admet-2268	108	5	by	by	ADP
admet-2268	108	6	mixing	mix	VERB
admet-2268	108	7	samples	sample	NOUN
admet-2268	108	8	and	and	CCONJ
admet-2268	108	9	kbr	kbr	PROPN
admet-2268	108	10	at	at	ADP
admet-2268	108	11	a	a	DET
admet-2268	108	12	1:10	1:10	NUM
admet-2268	108	13	ratio	ratio	NOUN
admet-2268	108	14	.	.	PUNCT
admet-2268	109	1	the	the	DET
admet-2268	109	2	pellets	pellet	NOUN
admet-2268	109	3	were	be	AUX
admet-2268	109	4	kept	keep	VERB
admet-2268	109	5	in	in	ADP
admet-2268	109	6	the	the	DET
admet-2268	109	7	sample	sample	NOUN
admet-2268	109	8	holder	holder	NOUN
admet-2268	109	9	and	and	CCONJ
admet-2268	109	10	scanned	scan	VERB
admet-2268	109	11	from	from	ADP
admet-2268	109	12	4000	4000	NUM
admet-2268	109	13	to	to	ADP
admet-2268	109	14	400	400	NUM
admet-2268	109	15	cm-1	cm-1	NOUN
admet-2268	110	1	[	[	X
admet-2268	110	2	21	21	NUM
admet-2268	110	3	]	]	PUNCT
admet-2268	110	4	.	.	PUNCT
admet-2268	111	1	x	x	X
admet-2268	111	2	-	-	PUNCT
admet-2268	111	3	ray	ray	NOUN
admet-2268	111	4	diffraction	diffraction	NOUN
admet-2268	111	5	analysis	analysis	NOUN
admet-2268	111	6	to	to	PART
admet-2268	111	7	study	study	VERB
admet-2268	111	8	the	the	DET
admet-2268	111	9	lattice	lattice	NOUN
admet-2268	111	10	structure	structure	NOUN
admet-2268	111	11	,	,	PUNCT
admet-2268	111	12	x	x	ADJ
admet-2268	111	13	-	-	NOUN
admet-2268	111	14	ray	ray	NOUN
admet-2268	111	15	diffraction	diffraction	NOUN
admet-2268	111	16	(	(	PUNCT
admet-2268	111	17	xrd	xrd	NOUN
admet-2268	111	18	)	)	PUNCT
admet-2268	111	19	study	study	NOUN
admet-2268	111	20	of	of	ADP
admet-2268	111	21	berberine	berberine	PROPN
admet-2268	111	22	hcl	hcl	PROPN
admet-2268	111	23	,	,	PUNCT
admet-2268	111	24	diacerein	diacerein	ADJ
admet-2268	111	25	,	,	PUNCT
admet-2268	111	26	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	111	27	,	,	PUNCT
admet-2268	111	28	sodium	sodium	NOUN
admet-2268	111	29	deoxycholate	deoxycholate	VERB
admet-2268	111	30	,	,	PUNCT
admet-2268	111	31	and	and	CCONJ
admet-2268	111	32	drug	drug	NOUN
admet-2268	111	33	-	-	PUNCT
admet-2268	111	34	loaded	load	VERB
admet-2268	111	35	optimized	optimize	VERB
admet-2268	111	36	transferosomes	transferosome	NOUN
admet-2268	111	37	(	(	PUNCT
admet-2268	111	38	formulation	formulation	NOUN
admet-2268	111	39	ddt-10	ddt-10	NOUN
admet-2268	111	40	)	)	PUNCT
admet-2268	111	41	was	be	AUX
admet-2268	111	42	carried	carry	VERB
admet-2268	111	43	out	out	ADP
admet-2268	111	44	by	by	ADP
admet-2268	111	45	a	a	DET
admet-2268	111	46	x	x	NOUN
admet-2268	111	47	-	-	NOUN
admet-2268	111	48	ray	ray	NOUN
admet-2268	111	49	powder	powder	NOUN
admet-2268	111	50	diffractometer	diffractometer	NOUN
admet-2268	111	51	(	(	PUNCT
admet-2268	111	52	d8	d8	PROPN
admet-2268	111	53	advance	advance	NOUN
admet-2268	111	54	eco	eco	PROPN
admet-2268	111	55	,	,	PUNCT
admet-2268	111	56	bruker	bruker	PROPN
admet-2268	111	57	,	,	PUNCT
admet-2268	111	58	united	united	PROPN
admet-2268	111	59	states	states	PROPN
admet-2268	111	60	)	)	PUNCT
admet-2268	111	61	using	use	VERB
admet-2268	111	62	cu	cu	PROPN
admet-2268	111	63	kα	kα	PROPN
admet-2268	111	64	radiation	radiation	NOUN
admet-2268	111	65	with	with	ADP
admet-2268	111	66	a	a	DET
admet-2268	111	67	40	40	NUM
admet-2268	111	68	kv	kv	PROPN
admet-2268	111	69	voltage	voltage	NOUN
admet-2268	111	70	,	,	PUNCT
admet-2268	111	71	15.4	15.4	NUM
admet-2268	111	72	nm	nm	PRON
admet-2268	111	73	wavelength	wavelength	NOUN
admet-2268	111	74	,	,	PUNCT
admet-2268	111	75	and	and	CCONJ
admet-2268	111	76	200	200	NUM
admet-2268	111	77	ma	ma	PROPN
admet-2268	111	78	current	current	NOUN
admet-2268	111	79	.	.	PUNCT
admet-2268	112	1	samples	sample	NOUN
admet-2268	112	2	were	be	AUX
admet-2268	112	3	scanned	scan	VERB
admet-2268	112	4	within	within	ADP
admet-2268	112	5	the	the	DET
admet-2268	112	6	2	2	NUM
admet-2268	112	7	range	range	NOUN
admet-2268	112	8	of	of	ADP
admet-2268	112	9	0	0	NUM
admet-2268	112	10	-	-	SYM
admet-2268	112	11	90	90	NUM
admet-2268	112	12	°	°	NOUN
admet-2268	112	13	at	at	ADP
admet-2268	112	14	a	a	DET
admet-2268	112	15	step	step	NOUN
admet-2268	112	16	size	size	NOUN
admet-2268	112	17	of	of	ADP
admet-2268	112	18	0.02	0.02	NUM
admet-2268	112	19	°	°	NOUN
admet-2268	113	1	[	[	X
admet-2268	113	2	22	22	NUM
admet-2268	113	3	]	]	PUNCT
admet-2268	113	4	.	.	PUNCT
admet-2268	114	1	thermogravimetric	thermogravimetric	ADJ
admet-2268	114	2	analysis	analysis	NOUN
admet-2268	114	3	thermal	thermal	ADJ
admet-2268	114	4	gravimetric	gravimetric	ADJ
admet-2268	114	5	analysis	analysis	NOUN
admet-2268	114	6	(	(	PUNCT
admet-2268	114	7	tga-50	tga-50	ADJ
admet-2268	114	8	,	,	PUNCT
admet-2268	114	9	shimadzu	shimadzu	ADJ
admet-2268	114	10	,	,	PUNCT
admet-2268	114	11	japan	japan	PROPN
admet-2268	114	12	)	)	PUNCT
admet-2268	114	13	determined	determine	VERB
admet-2268	114	14	the	the	DET
admet-2268	114	15	thermal	thermal	ADJ
admet-2268	114	16	degradation	degradation	NOUN
admet-2268	114	17	properties	property	NOUN
admet-2268	114	18	of	of	ADP
admet-2268	114	19	berberine	berberine	PROPN
admet-2268	114	20	hcl	hcl	PROPN
admet-2268	114	21	,	,	PUNCT
admet-2268	114	22	diacerein	diacerein	ADJ
admet-2268	114	23	,	,	PUNCT
admet-2268	114	24	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	114	25	,	,	PUNCT
admet-2268	114	26	sodium	sodium	NOUN
admet-2268	114	27	deoxycholate	deoxycholate	VERB
admet-2268	114	28	,	,	PUNCT
admet-2268	114	29	and	and	CCONJ
admet-2268	114	30	drug	drug	NOUN
admet-2268	114	31	-	-	PUNCT
admet-2268	114	32	loaded	load	VERB
admet-2268	114	33	transferosomes	transferosome	NOUN
admet-2268	114	34	(	(	PUNCT
admet-2268	114	35	formulation	formulation	NOUN
admet-2268	114	36	ddt-10	ddt-10	VERB
admet-2268	114	37	)	)	PUNCT
admet-2268	114	38	.	.	PUNCT
admet-2268	115	1	the	the	DET
admet-2268	115	2	sample	sample	NOUN
admet-2268	115	3	(	(	PUNCT
admet-2268	115	4	5	5	NUM
admet-2268	115	5	mg	mg	NOUN
admet-2268	115	6	)	)	PUNCT
admet-2268	115	7	was	be	AUX
admet-2268	115	8	kept	keep	VERB
admet-2268	115	9	on	on	ADP
admet-2268	115	10	the	the	DET
admet-2268	115	11	crucible	crucible	NOUN
admet-2268	115	12	under	under	ADP
admet-2268	115	13	insert	insert	ADJ
admet-2268	115	14	conditions	condition	NOUN
admet-2268	115	15	,	,	PUNCT
admet-2268	115	16	and	and	CCONJ
admet-2268	115	17	the	the	DET
admet-2268	115	18	thermosgrams	thermosgram	NOUN
admet-2268	115	19	were	be	AUX
admet-2268	115	20	obtained	obtain	VERB
admet-2268	115	21	between	between	ADP
admet-2268	115	22	30	30	NUM
admet-2268	115	23	to	to	PART
admet-2268	115	24	900	900	NUM
admet-2268	115	25	°	°	NOUN
admet-2268	115	26	c	c	NOUN
admet-2268	116	1	[	[	X
admet-2268	116	2	20	20	NUM
admet-2268	116	3	]	]	PUNCT
admet-2268	116	4	.	.	PUNCT
admet-2268	117	1	morphological	morphological	ADJ
admet-2268	117	2	characterization	characterization	NOUN
admet-2268	117	3	high	high	ADJ
admet-2268	117	4	-	-	PUNCT
admet-2268	117	5	resolution	resolution	NOUN
admet-2268	117	6	transmission	transmission	NOUN
admet-2268	117	7	electron	electron	NOUN
admet-2268	117	8	microscopy	microscopy	NOUN
admet-2268	117	9	(	(	PUNCT
admet-2268	117	10	hr	hr	NOUN
admet-2268	117	11	-	-	PUNCT
admet-2268	117	12	tem	tem	NOUN
admet-2268	117	13	)	)	PUNCT
admet-2268	117	14	analysis	analysis	NOUN
admet-2268	117	15	(	(	PUNCT
admet-2268	117	16	jem	jem	PROPN
admet-2268	117	17	2100	2100	NUM
admet-2268	117	18	plus	plus	CCONJ
admet-2268	117	19	,	,	PUNCT
admet-2268	117	20	joel	joel	PROPN
admet-2268	117	21	,	,	PUNCT
admet-2268	117	22	japan	japan	PROPN
admet-2268	117	23	)	)	PUNCT
admet-2268	117	24	of	of	ADP
admet-2268	117	25	optimized	optimize	VERB
admet-2268	117	26	formulations	formulation	NOUN
admet-2268	117	27	was	be	AUX
admet-2268	117	28	done	do	VERB
admet-2268	117	29	at	at	ADP
admet-2268	117	30	80	80	NUM
admet-2268	117	31	kv	kv	NOUN
admet-2268	117	32	.	.	PUNCT
admet-2268	118	1	a	a	DET
admet-2268	118	2	drop	drop	NOUN
admet-2268	118	3	of	of	ADP
admet-2268	118	4	the	the	DET
admet-2268	118	5	diluted	diluted	ADJ
admet-2268	118	6	sample	sample	NOUN
admet-2268	118	7	was	be	AUX
admet-2268	118	8	placed	place	VERB
admet-2268	118	9	on	on	ADP
admet-2268	118	10	the	the	DET
admet-2268	118	11	carbon	carbon	NOUN
admet-2268	118	12	-	-	PUNCT
admet-2268	118	13	coated	coat	VERB
admet-2268	118	14	copper	copper	NOUN
admet-2268	118	15	grid	grid	NOUN
admet-2268	118	16	and	and	CCONJ
admet-2268	118	17	dried	dry	VERB
admet-2268	118	18	properly	properly	ADV
admet-2268	118	19	.	.	PUNCT
admet-2268	119	1	the	the	DET
admet-2268	119	2	extra	extra	ADJ
admet-2268	119	3	liquid	liquid	NOUN
admet-2268	119	4	was	be	AUX
admet-2268	119	5	removed	remove	VERB
admet-2268	119	6	using	use	VERB
admet-2268	119	7	tissue	tissue	NOUN
admet-2268	119	8	paper	paper	NOUN
admet-2268	119	9	.	.	PUNCT
admet-2268	120	1	the	the	DET
admet-2268	120	2	sample	sample	NOUN
admet-2268	120	3	was	be	AUX
admet-2268	120	4	stained	stain	VERB
admet-2268	120	5	and	and	CCONJ
admet-2268	120	6	dried	dry	VERB
admet-2268	120	7	.	.	PUNCT
admet-2268	121	1	the	the	DET
admet-2268	121	2	prepared	prepare	VERB
admet-2268	121	3	samples	sample	NOUN
admet-2268	121	4	were	be	AUX
admet-2268	121	5	analyzed	analyze	VERB
admet-2268	121	6	at	at	ADP
admet-2268	121	7	high	high	ADJ
admet-2268	121	8	resolution	resolution	NOUN
admet-2268	121	9	.	.	PUNCT
admet-2268	122	1	the	the	DET
admet-2268	122	2	surface	surface	NOUN
admet-2268	122	3	roughness	roughness	NOUN
admet-2268	122	4	of	of	ADP
admet-2268	122	5	the	the	DET
admet-2268	122	6	optimized	optimize	VERB
admet-2268	122	7	transferosomes	transferosome	NOUN
admet-2268	122	8	was	be	AUX
admet-2268	122	9	analyzed	analyze	VERB
admet-2268	122	10	using	use	VERB
admet-2268	122	11	atomic	atomic	ADJ
admet-2268	122	12	force	force	NOUN
admet-2268	122	13	microscopy	microscopy	NOUN
admet-2268	122	14	(	(	PUNCT
admet-2268	122	15	afm	afm	PROPN
admet-2268	122	16	)	)	PUNCT
admet-2268	122	17	(	(	PUNCT
admet-2268	122	18	nanosurf	nanosurf	PROPN
admet-2268	122	19	ng	ng	PROPN
admet-2268	122	20	,	,	PUNCT
admet-2268	122	21	liestal	liestal	PROPN
admet-2268	122	22	,	,	PUNCT
admet-2268	122	23	switzerland	switzerland	PROPN
admet-2268	122	24	)	)	PUNCT
admet-2268	122	25	.	.	PUNCT
admet-2268	123	1	for	for	ADP
admet-2268	123	2	afm	afm	PROPN
admet-2268	123	3	analysis	analysis	NOUN
admet-2268	123	4	,	,	PUNCT
admet-2268	123	5	a	a	DET
admet-2268	123	6	thin	thin	ADJ
admet-2268	123	7	film	film	NOUN
admet-2268	123	8	was	be	AUX
admet-2268	123	9	obtained	obtain	VERB
admet-2268	123	10	by	by	ADP
admet-2268	123	11	placing	place	VERB
admet-2268	123	12	a	a	DET
admet-2268	123	13	drop	drop	NOUN
admet-2268	123	14	of	of	ADP
admet-2268	123	15	dispersion	dispersion	NOUN
admet-2268	123	16	on	on	ADP
admet-2268	123	17	a	a	DET
admet-2268	123	18	thin	thin	ADJ
admet-2268	123	19	glass	glass	NOUN
admet-2268	123	20	slide	slide	NOUN
admet-2268	123	21	using	use	VERB
admet-2268	123	22	a	a	DET
admet-2268	123	23	spin	spin	NOUN
admet-2268	123	24	coater	coater	NOUN
admet-2268	123	25	.	.	PUNCT
admet-2268	124	1	images	image	NOUN
admet-2268	124	2	were	be	AUX
admet-2268	124	3	captured	capture	VERB
admet-2268	124	4	at	at	ADP
admet-2268	124	5	300	300	NUM
admet-2268	124	6	khz	khz	NOUN
admet-2268	124	7	cantilever	cantilever	NOUN
admet-2268	124	8	frequency	frequency	NOUN
admet-2268	124	9	,	,	PUNCT
admet-2268	124	10	256×256	256×256	NUM
admet-2268	124	11	-	-	ADJ
admet-2268	124	12	pixel	pixel	ADJ
admet-2268	124	13	resolution	resolution	NOUN
admet-2268	124	14	,	,	PUNCT
admet-2268	124	15	and	and	CCONJ
admet-2268	124	16	a	a	DET
admet-2268	124	17	nominal	nominal	ADJ
admet-2268	124	18	force	force	NOUN
admet-2268	124	19	constant	constant	ADJ
admet-2268	124	20	of	of	ADP
admet-2268	124	21	48	48	NUM
admet-2268	124	22	n	n	PRON
admet-2268	124	23	m-1	m-1	NOUN
admet-2268	124	24	at	at	ADP
admet-2268	124	25	room	room	NOUN
admet-2268	124	26	temperature	temperature	NOUN
admet-2268	124	27	[	[	X
admet-2268	124	28	22	22	NUM
admet-2268	124	29	]	]	PUNCT
admet-2268	124	30	.	.	PUNCT
admet-2268	125	1	determination	determination	NOUN
admet-2268	125	2	of	of	ADP
admet-2268	125	3	deformability	deformability	NOUN
admet-2268	125	4	the	the	DET
admet-2268	125	5	deformability	deformability	NOUN
admet-2268	125	6	of	of	ADP
admet-2268	125	7	the	the	DET
admet-2268	125	8	optimized	optimize	VERB
admet-2268	125	9	formulation	formulation	NOUN
admet-2268	125	10	(	(	PUNCT
admet-2268	125	11	formulation	formulation	NOUN
admet-2268	125	12	ddt-10	ddt-10	NOUN
admet-2268	125	13	)	)	PUNCT
admet-2268	125	14	was	be	AUX
admet-2268	125	15	determined	determine	VERB
admet-2268	125	16	by	by	ADP
admet-2268	125	17	the	the	DET
admet-2268	125	18	extrusion	extrusion	NOUN
admet-2268	125	19	method	method	NOUN
admet-2268	125	20	.	.	PUNCT
admet-2268	126	1	briefly	briefly	ADV
admet-2268	126	2	,	,	PUNCT
admet-2268	126	3	the	the	DET
admet-2268	126	4	vesicle	vesicle	NOUN
admet-2268	126	5	size	size	NOUN
admet-2268	126	6	of	of	ADP
admet-2268	126	7	the	the	DET
admet-2268	126	8	optimized	optimize	VERB
admet-2268	126	9	formulation	formulation	NOUN
admet-2268	126	10	was	be	AUX
admet-2268	126	11	determined	determine	VERB
admet-2268	126	12	by	by	ADP
admet-2268	126	13	dls	dls	PROPN
admet-2268	126	14	before	before	ADP
admet-2268	126	15	passing	pass	VERB
admet-2268	126	16	them	they	PRON
admet-2268	126	17	through	through	ADP
admet-2268	126	18	the	the	DET
admet-2268	126	19	extruder	extruder	NOUN
admet-2268	126	20	.	.	PUNCT
admet-2268	127	1	the	the	DET
admet-2268	127	2	vesicle	vesicle	NOUN
admet-2268	127	3	size	size	NOUN
admet-2268	127	4	was	be	AUX
admet-2268	127	5	further	far	ADV
admet-2268	127	6	determined	determine	VERB
admet-2268	127	7	after	after	ADP
admet-2268	127	8	passing	pass	VERB
admet-2268	127	9	through	through	ADP
admet-2268	127	10	the	the	DET
admet-2268	127	11	extruder	extruder	NOUN
admet-2268	127	12	containing	contain	VERB
admet-2268	127	13	a	a	DET
admet-2268	127	14	polycarbonate	polycarbonate	ADJ
admet-2268	127	15	membrane	membrane	NOUN
admet-2268	127	16	filter	filter	NOUN
admet-2268	127	17	of	of	ADP
admet-2268	127	18	pore	pore	ADJ
admet-2268	127	19	size	size	NOUN
admet-2268	127	20	100	100	NUM
admet-2268	127	21	nm	nm	NOUN
admet-2268	127	22	.	.	PUNCT
admet-2268	128	1	the	the	DET
admet-2268	128	2	deformability	deformability	NOUN
admet-2268	128	3	of	of	ADP
admet-2268	128	4	the	the	DET
admet-2268	128	5	transferosomes	transferosome	NOUN
admet-2268	128	6	was	be	AUX
admet-2268	128	7	calculated	calculate	VERB
admet-2268	128	8	using	use	VERB
admet-2268	128	9	equation	equation	NOUN
admet-2268	128	10	(	(	PUNCT
admet-2268	128	11	4	4	NUM
admet-2268	128	12	)	)	PUNCT
admet-2268	129	1	[	[	X
admet-2268	129	2	23	23	NUM
admet-2268	129	3	]	]	X
admet-2268	129	4	:	:	PUNCT
admet-2268	129	5	deformability	deformability	NOUN
admet-2268	129	6	=	=	SYM
admet-2268	129	7	j	j	PROPN
admet-2268	129	8	(	(	PUNCT
admet-2268	129	9	rv	rv	PROPN
admet-2268	129	10	/	/	SYM
admet-2268	129	11	rp)2	rp)2	PROPN
admet-2268	129	12	(	(	PUNCT
admet-2268	129	13	4	4	NUM
admet-2268	129	14	)	)	PUNCT
admet-2268	129	15	where	where	SCONJ
admet-2268	129	16	d	d	NOUN
admet-2268	129	17	is	be	AUX
admet-2268	129	18	the	the	DET
admet-2268	129	19	deformability	deformability	PROPN
admet-2268	129	20	index	index	NOUN
admet-2268	129	21	,	,	PUNCT
admet-2268	129	22	j	j	PROPN
admet-2268	129	23	is	be	AUX
admet-2268	129	24	the	the	DET
admet-2268	129	25	amount	amount	NOUN
admet-2268	129	26	of	of	ADP
admet-2268	129	27	transferosome	transferosome	ADJ
admet-2268	129	28	suspension	suspension	NOUN
admet-2268	129	29	extruded	extrude	VERB
admet-2268	129	30	,	,	PUNCT
admet-2268	129	31	rv	rv	PROPN
admet-2268	129	32	is	be	AUX
admet-2268	129	33	the	the	DET
admet-2268	129	34	vesicle	vesicle	NOUN
admet-2268	129	35	size	size	NOUN
admet-2268	129	36	after	after	ADP
admet-2268	129	37	extrusion	extrusion	NOUN
admet-2268	129	38	,	,	PUNCT
admet-2268	129	39	rp	rp	NOUN
admet-2268	129	40	is	be	AUX
admet-2268	129	41	the	the	DET
admet-2268	129	42	pore	pore	ADJ
admet-2268	129	43	size	size	NOUN
admet-2268	129	44	of	of	ADP
admet-2268	129	45	the	the	DET
admet-2268	129	46	membrane	membrane	NOUN
admet-2268	129	47	.	.	PUNCT
admet-2268	130	1	antioxidant	antioxidant	ADJ
admet-2268	130	2	assay	assay	NOUN
admet-2268	130	3	of	of	ADP
admet-2268	130	4	transferosomes	transferosome	NOUN
admet-2268	130	5	the	the	DET
admet-2268	130	6	antioxidant	antioxidant	ADJ
admet-2268	130	7	activity	activity	NOUN
admet-2268	130	8	was	be	AUX
admet-2268	130	9	determined	determine	VERB
admet-2268	130	10	by	by	ADP
admet-2268	130	11	the	the	DET
admet-2268	130	12	dpph	dpph	PROPN
admet-2268	130	13	(	(	PUNCT
admet-2268	130	14	2,2	2,2	NUM
admet-2268	130	15	-	-	PUNCT
admet-2268	130	16	diphenyl-1	diphenyl-1	NUM
admet-2268	130	17	-	-	PUNCT
admet-2268	130	18	picrylhydrazyl	picrylhydrazyl	NOUN
admet-2268	130	19	)	)	PUNCT
admet-2268	130	20	assay	assay	NOUN
admet-2268	130	21	method	method	NOUN
admet-2268	130	22	.	.	PUNCT
admet-2268	131	1	the	the	DET
admet-2268	131	2	dpph	dpph	PROPN
admet-2268	131	3	agent	agent	NOUN
admet-2268	131	4	used	use	VERB
admet-2268	131	5	for	for	ADP
admet-2268	131	6	free	free	ADJ
admet-2268	131	7	radical	radical	ADJ
admet-2268	131	8	formation	formation	NOUN
admet-2268	131	9	exhibited	exhibit	VERB
admet-2268	131	10	absorption	absorption	NOUN
admet-2268	131	11	band	band	NOUN
admet-2268	131	12	at	at	ADP
admet-2268	131	13	517	517	NUM
admet-2268	131	14	nm	nm	NOUN
admet-2268	131	15	.	.	PUNCT
admet-2268	132	1	eight	eight	NUM
admet-2268	132	2	different	different	ADJ
admet-2268	132	3	concentrations	concentration	NOUN
admet-2268	132	4	(	(	PUNCT
admet-2268	132	5	3.9	3.9	NUM
admet-2268	132	6	,	,	PUNCT
admet-2268	132	7	7.8	7.8	NUM
admet-2268	132	8	,	,	PUNCT
admet-2268	132	9	15.6	15.6	NUM
admet-2268	132	10	,	,	PUNCT
admet-2268	132	11	31.25	31.25	NUM
admet-2268	132	12	,	,	PUNCT
admet-2268	132	13	62.5	62.5	NUM
admet-2268	132	14	,	,	PUNCT
admet-2268	132	15	125,250	125,250	NUM
admet-2268	132	16	,	,	PUNCT
admet-2268	132	17	and	and	CCONJ
admet-2268	132	18	500	500	NUM
admet-2268	132	19	µg	µg	ADV
admet-2268	132	20	/	/	SYM
admet-2268	132	21	ml	ml	NOUN
admet-2268	132	22	)	)	PUNCT
admet-2268	132	23	of	of	ADP
admet-2268	132	24	ascorbic	ascorbic	NOUN
admet-2268	132	25	acid	acid	NOUN
admet-2268	132	26	(	(	PUNCT
admet-2268	132	27	standard	standard	ADJ
admet-2268	132	28	sample	sample	NOUN
admet-2268	132	29	)	)	PUNCT
admet-2268	132	30	and	and	CCONJ
admet-2268	132	31	optimized	optimize	VERB
admet-2268	132	32	transferosomes	transferosome	NOUN
admet-2268	132	33	(	(	PUNCT
admet-2268	132	34	test	test	NOUN
admet-2268	132	35	sample	sample	NOUN
admet-2268	132	36	)	)	PUNCT
admet-2268	132	37	were	be	AUX
admet-2268	132	38	prepared	prepare	VERB
admet-2268	132	39	and	and	CCONJ
admet-2268	132	40	mixed	mix	VERB
admet-2268	132	41	with	with	ADP
admet-2268	132	42	0.004	0.004	NUM
admet-2268	132	43	%	%	NOUN
admet-2268	132	44	w	w	PROPN
admet-2268	132	45	/	/	SYM
admet-2268	132	46	v	v	NOUN
admet-2268	132	47	solution	solution	NOUN
admet-2268	132	48	of	of	ADP
admet-2268	132	49	dpph	dpph	PROPN
admet-2268	132	50	.	.	PUNCT
admet-2268	133	1	the	the	DET
admet-2268	133	2	mixture	mixture	NOUN
admet-2268	133	3	was	be	AUX
admet-2268	133	4	incubated	incubate	VERB
admet-2268	133	5	for	for	ADP
admet-2268	133	6	15	15	NUM
admet-2268	133	7	minutes	minute	NOUN
admet-2268	133	8	under	under	ADP
admet-2268	133	9	dark	dark	ADJ
admet-2268	133	10	conditions	condition	NOUN
admet-2268	133	11	at	at	ADP
admet-2268	133	12	25	25	NUM
admet-2268	133	13	°	°	NOUN
admet-2268	133	14	c	c	NOUN
admet-2268	133	15	.	.	PUNCT
admet-2268	134	1	the	the	DET
admet-2268	134	2	solution	solution	NOUN
admet-2268	134	3	color	color	NOUN
admet-2268	134	4	changed	change	VERB
admet-2268	134	5	from	from	ADP
admet-2268	134	6	purple	purple	ADJ
admet-2268	134	7	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	134	8	s.	s.	PROPN
admet-2268	134	9	singh	singh	PROPN
admet-2268	134	10	and	and	CCONJ
admet-2268	134	11	r.	r.	PROPN
admet-2268	134	12	awasthi	awasthi	PROPN
admet-2268	134	13	admet	admet	PROPN
admet-2268	134	14	&	&	CCONJ
admet-2268	134	15	dmpk	dmpk	PROPN
admet-2268	134	16	12(3	12(3	PROPN
admet-2268	134	17	)	)	PUNCT
admet-2268	134	18	(	(	PUNCT
admet-2268	134	19	2024	2024	NUM
admet-2268	134	20	)	)	PUNCT
admet-2268	135	1	553	553	NUM
admet-2268	135	2	-	-	SYM
admet-2268	135	3	580	580	NUM
admet-2268	135	4	558	558	NUM
admet-2268	135	5	to	to	PART
admet-2268	135	6	yellow	yellow	VERB
admet-2268	135	7	after	after	ADP
admet-2268	135	8	incubation	incubation	NOUN
admet-2268	135	9	.	.	PUNCT
admet-2268	136	1	the	the	DET
admet-2268	136	2	sample	sample	NOUN
admet-2268	136	3	absorbance	absorbance	NOUN
admet-2268	136	4	was	be	AUX
admet-2268	136	5	recorded	record	VERB
admet-2268	136	6	at	at	ADP
admet-2268	136	7	517	517	NUM
admet-2268	136	8	nm	nm	NOUN
admet-2268	136	9	using	use	VERB
admet-2268	136	10	a	a	DET
admet-2268	136	11	uv	uv	NOUN
admet-2268	136	12	spectrophotometer	spectrophotometer	NOUN
admet-2268	136	13	(	(	PUNCT
admet-2268	136	14	uv-1900	uv-1900	PROPN
admet-2268	136	15	,	,	PUNCT
admet-2268	136	16	shimadzu	shimadzu	PROPN
admet-2268	136	17	,	,	PUNCT
admet-2268	136	18	japan	japan	PROPN
admet-2268	136	19	)	)	PUNCT
admet-2268	136	20	.	.	PUNCT
admet-2268	137	1	the	the	DET
admet-2268	137	2	antioxidant	antioxidant	ADJ
admet-2268	137	3	activity	activity	NOUN
admet-2268	137	4	was	be	AUX
admet-2268	137	5	determined	determine	VERB
admet-2268	137	6	using	use	VERB
admet-2268	137	7	equation	equation	NOUN
admet-2268	137	8	5	5	NUM
admet-2268	137	9	.	.	PUNCT
admet-2268	138	1	the	the	DET
admet-2268	138	2	ic50	ic50	PROPN
admet-2268	138	3	(	(	PUNCT
admet-2268	138	4	halfmaximal	halfmaximal	ADJ
admet-2268	138	5	inhibitory	inhibitory	ADJ
admet-2268	138	6	concentration	concentration	NOUN
admet-2268	138	7	)	)	PUNCT
admet-2268	138	8	value	value	NOUN
admet-2268	138	9	of	of	ADP
admet-2268	138	10	optimized	optimize	VERB
admet-2268	138	11	transferosomes	transferosome	NOUN
admet-2268	138	12	was	be	AUX
admet-2268	138	13	determined	determine	VERB
admet-2268	138	14	and	and	CCONJ
admet-2268	138	15	compared	compare	VERB
admet-2268	138	16	against	against	ADP
admet-2268	138	17	ascorbic	ascorbic	NOUN
admet-2268	138	18	acid	acid	NOUN
admet-2268	138	19	(	(	PUNCT
admet-2268	138	20	antioxidant	antioxidant	ADJ
admet-2268	138	21	standard	standard	NOUN
admet-2268	138	22	)	)	PUNCT
admet-2268	139	1	[	[	X
admet-2268	139	2	24	24	NUM
admet-2268	139	3	]	]	PUNCT
admet-2268	139	4	.	.	PUNCT
admet-2268	140	1	absorbance	absorbance	NOUN
admet-2268	140	2	of	of	ADP
admet-2268	140	3	dpph	dpph	PROPN
admet-2268	140	4	sample	sample	PROPN
admet-2268	140	5	absorbance	absorbance	NOUN
admet-2268	140	6	antioxidant	antioxidant	NOUN
admet-2268	140	7	activity	activity	NOUN
admet-2268	140	8	,	,	PUNCT
admet-2268	140	9	%	%	NOUN
admet-2268	140	10	=	=	SYM
admet-2268	140	11	100	100	NUM
admet-2268	140	12	absorbance	absorbance	NOUN
admet-2268	140	13	of	of	ADP
admet-2268	140	14	dpph	dpph	PROPN
admet-2268	140	15	(	(	PUNCT
admet-2268	140	16	5	5	NUM
admet-2268	140	17	)	)	PUNCT
admet-2268	140	18	.	.	PUNCT
admet-2268	141	1	in	in	ADP
admet-2268	141	2	vitro	vitro	X
admet-2268	141	3	release	release	NOUN
admet-2268	141	4	studies	study	NOUN
admet-2268	141	5	the	the	DET
admet-2268	141	6	formulated	formulate	VERB
admet-2268	141	7	transferosomes	transferosome	NOUN
admet-2268	141	8	were	be	AUX
admet-2268	141	9	subjected	subject	VERB
admet-2268	141	10	to	to	PART
admet-2268	141	11	release	release	VERB
admet-2268	141	12	studies	study	NOUN
admet-2268	141	13	using	use	VERB
admet-2268	141	14	a	a	DET
admet-2268	141	15	usp	usp	NOUN
admet-2268	141	16	type	type	NOUN
admet-2268	141	17	ii	ii	PROPN
admet-2268	141	18	dissolution	dissolution	NOUN
admet-2268	141	19	apparatus	apparatus	NOUN
admet-2268	141	20	.	.	PUNCT
admet-2268	142	1	the	the	DET
admet-2268	142	2	dialysis	dialysis	NOUN
admet-2268	142	3	membrane	membrane	NOUN
admet-2268	142	4	was	be	AUX
admet-2268	142	5	activated	activate	VERB
admet-2268	142	6	by	by	ADP
admet-2268	142	7	heating	heat	VERB
admet-2268	142	8	it	it	PRON
admet-2268	142	9	in	in	ADP
admet-2268	142	10	a	a	DET
admet-2268	142	11	sodium	sodium	NOUN
admet-2268	142	12	bicarbonate	bicarbonate	NOUN
admet-2268	142	13	solution	solution	NOUN
admet-2268	142	14	for	for	ADP
admet-2268	142	15	15	15	NUM
admet-2268	142	16	min	min	NOUN
admet-2268	142	17	,	,	PUNCT
admet-2268	142	18	followed	follow	VERB
admet-2268	142	19	by	by	ADP
admet-2268	142	20	washing	wash	VERB
admet-2268	142	21	it	it	PRON
admet-2268	142	22	with	with	ADP
admet-2268	142	23	double	double	ADJ
admet-2268	142	24	-	-	PUNCT
admet-2268	142	25	distilled	distil	VERB
admet-2268	142	26	water	water	NOUN
admet-2268	142	27	.	.	PUNCT
admet-2268	143	1	transferosomes	transferosome	NOUN
admet-2268	143	2	(	(	PUNCT
admet-2268	143	3	equivalent	equivalent	ADJ
admet-2268	143	4	to	to	ADP
admet-2268	143	5	5	5	NUM
admet-2268	143	6	mg	mg	ADP
admet-2268	143	7	of	of	ADP
admet-2268	143	8	berberine	berberine	PROPN
admet-2268	143	9	hcl	hcl	PROPN
admet-2268	143	10	and	and	CCONJ
admet-2268	143	11	5	5	NUM
admet-2268	143	12	mg	mg	NOUN
admet-2268	143	13	of	of	ADP
admet-2268	143	14	diacerein	diacerein	ADJ
admet-2268	143	15	)	)	PUNCT
admet-2268	143	16	were	be	AUX
admet-2268	143	17	taken	take	VERB
admet-2268	143	18	into	into	ADP
admet-2268	143	19	the	the	DET
admet-2268	143	20	dialysis	dialysis	NOUN
admet-2268	143	21	membrane	membrane	NOUN
admet-2268	143	22	and	and	CCONJ
admet-2268	143	23	placed	place	VERB
admet-2268	143	24	into	into	ADP
admet-2268	143	25	the	the	DET
admet-2268	143	26	dissolution	dissolution	NOUN
admet-2268	143	27	apparatus	apparatus	NOUN
admet-2268	143	28	(	(	PUNCT
admet-2268	143	29	filled	fill	VERB
admet-2268	143	30	with	with	ADP
admet-2268	143	31	pbs	pbs	PROPN
admet-2268	143	32	ph	ph	PROPN
admet-2268	143	33	7.4	7.4	NUM
admet-2268	143	34	)	)	PUNCT
admet-2268	143	35	.	.	PUNCT
admet-2268	144	1	the	the	DET
admet-2268	144	2	temperature	temperature	NOUN
admet-2268	144	3	of	of	ADP
admet-2268	144	4	the	the	DET
admet-2268	144	5	dissolution	dissolution	NOUN
admet-2268	144	6	medium	medium	NOUN
admet-2268	144	7	was	be	AUX
admet-2268	144	8	maintained	maintain	VERB
admet-2268	144	9	at	at	ADP
admet-2268	144	10	37±0.5	37±0.5	NUM
admet-2268	144	11	°	°	NOUN
admet-2268	144	12	c	c	NOUN
admet-2268	144	13	.	.	PUNCT
admet-2268	145	1	the	the	DET
admet-2268	145	2	paddles	paddle	NOUN
admet-2268	145	3	were	be	AUX
admet-2268	145	4	rotated	rotate	VERB
admet-2268	145	5	at	at	ADP
admet-2268	145	6	100	100	NUM
admet-2268	145	7	rpm	rpm	NOUN
admet-2268	145	8	.	.	PUNCT
admet-2268	146	1	the	the	DET
admet-2268	146	2	samples	sample	NOUN
admet-2268	146	3	(	(	PUNCT
admet-2268	146	4	5	5	NUM
admet-2268	146	5	ml	ml	NOUN
admet-2268	146	6	)	)	PUNCT
admet-2268	146	7	were	be	AUX
admet-2268	146	8	withdrawn	withdraw	VERB
admet-2268	146	9	in	in	ADP
admet-2268	146	10	triplicate	triplicate	NOUN
admet-2268	146	11	at	at	ADP
admet-2268	146	12	different	different	ADJ
admet-2268	146	13	intervals	interval	NOUN
admet-2268	146	14	(	(	PUNCT
admet-2268	146	15	0	0	NUM
admet-2268	146	16	,	,	PUNCT
admet-2268	146	17	1	1	NUM
admet-2268	146	18	,	,	PUNCT
admet-2268	146	19	2	2	NUM
admet-2268	146	20	,	,	PUNCT
admet-2268	146	21	3	3	NUM
admet-2268	146	22	,	,	PUNCT
admet-2268	146	23	4	4	NUM
admet-2268	146	24	,	,	PUNCT
admet-2268	146	25	5	5	NUM
admet-2268	146	26	,	,	PUNCT
admet-2268	146	27	6	6	NUM
admet-2268	146	28	,	,	PUNCT
admet-2268	146	29	8	8	NUM
admet-2268	146	30	,	,	PUNCT
admet-2268	146	31	10	10	NUM
admet-2268	146	32	,	,	PUNCT
admet-2268	146	33	12	12	NUM
admet-2268	146	34	,	,	PUNCT
admet-2268	146	35	16	16	NUM
admet-2268	146	36	and	and	CCONJ
admet-2268	146	37	24	24	NUM
admet-2268	146	38	h	h	NOUN
admet-2268	146	39	)	)	PUNCT
admet-2268	146	40	.	.	PUNCT
admet-2268	147	1	the	the	DET
admet-2268	147	2	sink	sink	NOUN
admet-2268	147	3	condition	condition	NOUN
admet-2268	147	4	was	be	AUX
admet-2268	147	5	maintained	maintain	VERB
admet-2268	147	6	by	by	ADP
admet-2268	147	7	adding	add	VERB
admet-2268	147	8	5	5	NUM
admet-2268	147	9	ml	ml	NOUN
admet-2268	147	10	of	of	ADP
admet-2268	147	11	pbs	pbs	PROPN
admet-2268	147	12	(	(	PUNCT
admet-2268	147	13	ph	ph	NOUN
admet-2268	147	14	7.4	7.4	NUM
admet-2268	147	15	)	)	PUNCT
admet-2268	147	16	immediately	immediately	ADV
admet-2268	147	17	after	after	ADP
admet-2268	147	18	each	each	DET
admet-2268	147	19	sampling	sampling	NOUN
admet-2268	147	20	.	.	PUNCT
admet-2268	148	1	the	the	DET
admet-2268	148	2	samples	sample	NOUN
admet-2268	148	3	were	be	AUX
admet-2268	148	4	filtered	filter	VERB
admet-2268	148	5	and	and	CCONJ
admet-2268	148	6	analyzed	analyze	VERB
admet-2268	148	7	at	at	ADP
admet-2268	148	8	340	340	NUM
admet-2268	148	9	nm	nm	NOUN
admet-2268	148	10	for	for	ADP
admet-2268	148	11	berberine	berberine	NOUN
admet-2268	148	12	hcl	hcl	PROPN
admet-2268	148	13	and	and	CCONJ
admet-2268	148	14	258	258	NUM
admet-2268	148	15	nm	nm	NOUN
admet-2268	148	16	for	for	ADP
admet-2268	148	17	diacerein	diacerein	ADV
admet-2268	148	18	using	use	VERB
admet-2268	148	19	a	a	DET
admet-2268	148	20	uv	uv	NOUN
admet-2268	148	21	spectrophotometer	spectrophotometer	NOUN
admet-2268	148	22	(	(	PUNCT
admet-2268	148	23	uv-1900	uv-1900	PROPN
admet-2268	148	24	,	,	PUNCT
admet-2268	148	25	shimadzu	shimadzu	PROPN
admet-2268	148	26	,	,	PUNCT
admet-2268	148	27	japan	japan	PROPN
admet-2268	148	28	)	)	PUNCT
admet-2268	148	29	.	.	PUNCT
admet-2268	149	1	the	the	DET
admet-2268	149	2	cumulative	cumulative	ADJ
admet-2268	149	3	drug	drug	NOUN
admet-2268	149	4	release	release	NOUN
admet-2268	149	5	was	be	AUX
admet-2268	149	6	calculated	calculate	VERB
admet-2268	149	7	and	and	CCONJ
admet-2268	149	8	plotted	plot	VERB
admet-2268	149	9	against	against	ADP
admet-2268	149	10	time	time	NOUN
admet-2268	149	11	[	[	X
admet-2268	149	12	13	13	NUM
admet-2268	149	13	]	]	PUNCT
admet-2268	149	14	.	.	PUNCT
admet-2268	150	1	berberine	berberine	PROPN
admet-2268	150	2	hcl	hcl	PROPN
admet-2268	150	3	and	and	CCONJ
admet-2268	150	4	diacerein	diacerein	ADJ
admet-2268	150	5	release	release	VERB
admet-2268	150	6	kinetics	kinetic	NOUN
admet-2268	150	7	from	from	ADP
admet-2268	150	8	dual	dual	ADJ
admet-2268	150	9	delivery	delivery	NOUN
admet-2268	150	10	transferosomes	transferosome	NOUN
admet-2268	150	11	were	be	AUX
admet-2268	150	12	assessed	assess	VERB
admet-2268	150	13	for	for	ADP
admet-2268	150	14	zero	zero	NUM
admet-2268	150	15	order	order	NOUN
admet-2268	150	16	(	(	PUNCT
admet-2268	150	17	cumulative	cumulative	ADJ
admet-2268	150	18	drug	drug	NOUN
admet-2268	150	19	release	release	NOUN
admet-2268	150	20	against	against	ADP
admet-2268	150	21	time	time	NOUN
admet-2268	150	22	)	)	PUNCT
admet-2268	150	23	and	and	CCONJ
admet-2268	150	24	first	first	ADJ
admet-2268	150	25	order	order	NOUN
admet-2268	150	26	(	(	PUNCT
admet-2268	150	27	log	log	NOUN
admet-2268	150	28	of	of	ADP
admet-2268	150	29	cumulative	cumulative	ADJ
admet-2268	150	30	drug	drug	NOUN
admet-2268	150	31	remaining	remain	VERB
admet-2268	150	32	against	against	ADP
admet-2268	150	33	time	time	NOUN
admet-2268	150	34	)	)	PUNCT
admet-2268	150	35	kinetics	kinetic	NOUN
admet-2268	150	36	.	.	PUNCT
admet-2268	151	1	cumulative	cumulative	ADJ
admet-2268	151	2	percent	percent	NOUN
admet-2268	151	3	drug	drug	NOUN
admet-2268	151	4	release	release	NOUN
admet-2268	151	5	against	against	ADP
admet-2268	151	6	the	the	DET
admet-2268	151	7	square	square	ADJ
admet-2268	151	8	root	root	NOUN
admet-2268	151	9	of	of	ADP
admet-2268	151	10	the	the	DET
admet-2268	151	11	time	time	NOUN
admet-2268	151	12	plot	plot	NOUN
admet-2268	151	13	was	be	AUX
admet-2268	151	14	used	use	VERB
admet-2268	151	15	to	to	PART
admet-2268	151	16	confirm	confirm	VERB
admet-2268	151	17	the	the	DET
admet-2268	151	18	drug	drug	NOUN
admet-2268	151	19	release	release	NOUN
admet-2268	151	20	kinetics	kinetic	NOUN
admet-2268	151	21	(	(	PUNCT
admet-2268	151	22	higuchi	higuchi	PROPN
admet-2268	151	23	’s	’s	PART
admet-2268	151	24	model	model	NOUN
admet-2268	151	25	)	)	PUNCT
admet-2268	151	26	.	.	PUNCT
admet-2268	152	1	to	to	PART
admet-2268	152	2	confirm	confirm	VERB
admet-2268	152	3	the	the	DET
admet-2268	152	4	drug	drug	NOUN
admet-2268	152	5	diffusion	diffusion	NOUN
admet-2268	152	6	mechanism	mechanism	NOUN
admet-2268	152	7	(	(	PUNCT
admet-2268	152	8	non	non	ADJ
admet-2268	152	9	-	-	ADJ
admet-2268	152	10	fickian	fickian	ADJ
admet-2268	152	11	or	or	CCONJ
admet-2268	152	12	fickian	fickian	ADJ
admet-2268	152	13	)	)	PUNCT
admet-2268	152	14	,	,	PUNCT
admet-2268	152	15	the	the	DET
admet-2268	152	16	in	in	ADV
admet-2268	152	17	vitro	vitro	X
admet-2268	152	18	release	release	NOUN
admet-2268	152	19	data	datum	NOUN
admet-2268	152	20	was	be	AUX
admet-2268	152	21	analyzed	analyze	VERB
admet-2268	152	22	according	accord	VERB
admet-2268	152	23	to	to	ADP
admet-2268	152	24	the	the	DET
admet-2268	152	25	korsmeyer	korsmeyer	NOUN
admet-2268	152	26	-	-	PUNCT
admet-2268	152	27	peppas	peppas	NOUN
admet-2268	152	28	model	model	NOUN
admet-2268	152	29	(	(	PUNCT
admet-2268	152	30	log	log	NOUN
admet-2268	152	31	cumulative	cumulative	ADJ
admet-2268	152	32	percent	percent	NOUN
admet-2268	152	33	drug	drug	NOUN
admet-2268	152	34	release	release	NOUN
admet-2268	152	35	against	against	ADP
admet-2268	152	36	log	log	NOUN
admet-2268	152	37	time	time	NOUN
admet-2268	152	38	)	)	PUNCT
admet-2268	152	39	.	.	PUNCT
admet-2268	153	1	the	the	DET
admet-2268	153	2	hixson	hixson	PROPN
admet-2268	153	3	-	-	PUNCT
admet-2268	153	4	crowell	crowell	PROPN
admet-2268	153	5	model	model	NOUN
admet-2268	153	6	was	be	AUX
admet-2268	153	7	applied	apply	VERB
admet-2268	153	8	to	to	ADP
admet-2268	153	9	the	the	DET
admet-2268	153	10	in	in	X
admet-2268	153	11	vitro	vitro	X
admet-2268	153	12	drug	drug	NOUN
admet-2268	153	13	release	release	NOUN
admet-2268	153	14	data	datum	NOUN
admet-2268	153	15	(	(	PUNCT
admet-2268	153	16	cube	cube	NOUN
admet-2268	153	17	root	root	NOUN
admet-2268	153	18	of	of	ADP
admet-2268	153	19	drug	drug	NOUN
admet-2268	153	20	amount	amount	NOUN
admet-2268	153	21	remaining	remain	VERB
admet-2268	153	22	in	in	ADP
admet-2268	153	23	matrix	matrix	NOUN
admet-2268	153	24	versus	versus	ADP
admet-2268	153	25	time	time	NOUN
admet-2268	153	26	)	)	PUNCT
admet-2268	153	27	.	.	PUNCT
admet-2268	154	1	the	the	DET
admet-2268	154	2	release	release	NOUN
admet-2268	154	3	mechanism	mechanism	NOUN
admet-2268	154	4	assessment	assessment	NOUN
admet-2268	154	5	was	be	AUX
admet-2268	154	6	based	base	VERB
admet-2268	154	7	on	on	ADP
admet-2268	154	8	the	the	DET
admet-2268	154	9	regression	regression	NOUN
admet-2268	154	10	coefficient	coefficient	NOUN
admet-2268	154	11	value	value	NOUN
admet-2268	154	12	[	[	X
admet-2268	154	13	18	18	NUM
admet-2268	154	14	]	]	PUNCT
admet-2268	154	15	.	.	PUNCT
admet-2268	155	1	pcp	pcp	PROPN
admet-2268	155	2	disso	disso	PROPN
admet-2268	155	3	v3	v3	PROPN
admet-2268	155	4	software	software	PROPN
admet-2268	155	5	(	(	PUNCT
admet-2268	155	6	pcp	pcp	PROPN
admet-2268	155	7	,	,	PUNCT
admet-2268	155	8	bvdu	bvdu	NOUN
admet-2268	155	9	,	,	PUNCT
admet-2268	155	10	pune	pune	NOUN
admet-2268	155	11	,	,	PUNCT
admet-2268	155	12	india	india	PROPN
admet-2268	155	13	)	)	PUNCT
admet-2268	155	14	was	be	AUX
admet-2268	155	15	used	use	VERB
admet-2268	155	16	to	to	PART
admet-2268	155	17	plot	plot	VERB
admet-2268	155	18	calibration	calibration	NOUN
admet-2268	155	19	curves	curve	NOUN
admet-2268	155	20	and	and	CCONJ
admet-2268	155	21	determine	determine	VERB
admet-2268	155	22	the	the	DET
admet-2268	155	23	cumulative	cumulative	ADJ
admet-2268	155	24	drug	drug	NOUN
admet-2268	155	25	release	release	NOUN
admet-2268	155	26	and	and	CCONJ
admet-2268	155	27	kinetic	kinetic	ADJ
admet-2268	155	28	modeling	modeling	NOUN
admet-2268	155	29	.	.	PUNCT
admet-2268	156	1	ex	ex	PRON
admet-2268	156	2	vivo	vivo	ADJ
admet-2268	156	3	permeation	permeation	NOUN
admet-2268	156	4	studies	study	NOUN
admet-2268	156	5	ex	ex	PRON
admet-2268	156	6	vivo	vivo	ADJ
admet-2268	156	7	skin	skin	NOUN
admet-2268	156	8	permeation	permeation	NOUN
admet-2268	156	9	studies	study	NOUN
admet-2268	156	10	were	be	AUX
admet-2268	156	11	performed	perform	VERB
admet-2268	156	12	using	use	VERB
admet-2268	156	13	hairless	hairless	ADJ
admet-2268	156	14	pig	pig	NOUN
admet-2268	156	15	ear	ear	NOUN
admet-2268	156	16	skin	skin	NOUN
admet-2268	156	17	collected	collect	VERB
admet-2268	156	18	from	from	ADP
admet-2268	156	19	a	a	DET
admet-2268	156	20	slaughterhouse	slaughterhouse	NOUN
admet-2268	156	21	(	(	PUNCT
admet-2268	156	22	dehradun	dehradun	PROPN
admet-2268	156	23	,	,	PUNCT
admet-2268	156	24	india	india	PROPN
admet-2268	156	25	)	)	PUNCT
admet-2268	156	26	.	.	PUNCT
admet-2268	157	1	the	the	DET
admet-2268	157	2	skin	skin	NOUN
admet-2268	157	3	was	be	AUX
admet-2268	157	4	washed	wash	VERB
admet-2268	157	5	with	with	ADP
admet-2268	157	6	pbs	pbs	PROPN
admet-2268	157	7	(	(	PUNCT
admet-2268	157	8	ph	ph	PROPN
admet-2268	157	9	7.4	7.4	NUM
admet-2268	157	10	)	)	PUNCT
admet-2268	157	11	,	,	PUNCT
admet-2268	157	12	packed	pack	VERB
admet-2268	157	13	,	,	PUNCT
admet-2268	157	14	and	and	CCONJ
admet-2268	157	15	stored	store	VERB
admet-2268	157	16	in	in	ADP
admet-2268	157	17	a	a	DET
admet-2268	157	18	freezer	freezer	NOUN
admet-2268	157	19	at	at	ADP
admet-2268	157	20	-8	-8	NOUN
admet-2268	157	21	°	°	ADP
admet-2268	157	22	c	c	NOUN
admet-2268	157	23	.	.	PUNCT
admet-2268	158	1	the	the	DET
admet-2268	158	2	study	study	NOUN
admet-2268	158	3	was	be	AUX
admet-2268	158	4	carried	carry	VERB
admet-2268	158	5	out	out	ADP
admet-2268	158	6	using	use	VERB
admet-2268	158	7	a	a	DET
admet-2268	158	8	franz	franz	NOUN
admet-2268	158	9	diffusion	diffusion	NOUN
admet-2268	158	10	cell	cell	NOUN
admet-2268	158	11	in	in	ADP
admet-2268	158	12	which	which	PRON
admet-2268	158	13	pig	pig	NOUN
admet-2268	158	14	skin	skin	NOUN
admet-2268	158	15	was	be	AUX
admet-2268	158	16	mounted	mount	VERB
admet-2268	158	17	between	between	ADP
admet-2268	158	18	the	the	DET
admet-2268	158	19	donor	donor	NOUN
admet-2268	158	20	and	and	CCONJ
admet-2268	158	21	receiver	receiver	ADJ
admet-2268	158	22	compartments	compartment	NOUN
admet-2268	158	23	.	.	PUNCT
admet-2268	159	1	the	the	DET
admet-2268	159	2	formulation	formulation	NOUN
admet-2268	159	3	was	be	AUX
admet-2268	159	4	applied	apply	VERB
admet-2268	159	5	to	to	ADP
admet-2268	159	6	the	the	DET
admet-2268	159	7	skin	skin	NOUN
admet-2268	159	8	uniformly	uniformly	ADV
admet-2268	159	9	.	.	PUNCT
admet-2268	160	1	the	the	DET
admet-2268	160	2	outer	outer	ADJ
admet-2268	160	3	layer	layer	NOUN
admet-2268	160	4	of	of	ADP
admet-2268	160	5	the	the	DET
admet-2268	160	6	skin	skin	NOUN
admet-2268	160	7	was	be	AUX
admet-2268	160	8	set	set	VERB
admet-2268	160	9	towards	towards	ADP
admet-2268	160	10	the	the	DET
admet-2268	160	11	facing	face	VERB
admet-2268	160	12	donor	donor	NOUN
admet-2268	160	13	compartment	compartment	NOUN
admet-2268	160	14	and	and	CCONJ
admet-2268	160	15	the	the	DET
admet-2268	160	16	internal	internal	ADJ
admet-2268	160	17	layer	layer	NOUN
admet-2268	160	18	towards	towards	ADP
admet-2268	160	19	the	the	DET
admet-2268	160	20	receiver	receiver	ADJ
admet-2268	160	21	compartment	compartment	NOUN
admet-2268	160	22	,	,	PUNCT
admet-2268	160	23	which	which	PRON
admet-2268	160	24	was	be	AUX
admet-2268	160	25	filled	fill	VERB
admet-2268	160	26	with	with	ADP
admet-2268	160	27	pbs	pbs	PROPN
admet-2268	160	28	(	(	PUNCT
admet-2268	160	29	ph	ph	PROPN
admet-2268	160	30	7.4	7.4	NUM
admet-2268	160	31	)	)	PUNCT
admet-2268	160	32	.	.	PUNCT
admet-2268	161	1	samples	sample	NOUN
admet-2268	161	2	(	(	PUNCT
admet-2268	161	3	2	2	NUM
admet-2268	161	4	ml	ml	NOUN
admet-2268	161	5	)	)	PUNCT
admet-2268	161	6	were	be	AUX
admet-2268	161	7	withdrawn	withdraw	VERB
admet-2268	161	8	at	at	ADP
admet-2268	161	9	different	different	ADJ
admet-2268	161	10	time	time	NOUN
admet-2268	161	11	intervals	interval	NOUN
admet-2268	161	12	(	(	PUNCT
admet-2268	161	13	0	0	NUM
admet-2268	161	14	,	,	PUNCT
admet-2268	161	15	1	1	NUM
admet-2268	161	16	,	,	PUNCT
admet-2268	161	17	2	2	NUM
admet-2268	161	18	,	,	PUNCT
admet-2268	161	19	3	3	NUM
admet-2268	161	20	,	,	PUNCT
admet-2268	161	21	4	4	NUM
admet-2268	161	22	,	,	PUNCT
admet-2268	161	23	5	5	NUM
admet-2268	161	24	,	,	PUNCT
admet-2268	161	25	and	and	CCONJ
admet-2268	161	26	6	6	NUM
admet-2268	161	27	h	h	NOUN
admet-2268	161	28	)	)	PUNCT
admet-2268	161	29	.	.	PUNCT
admet-2268	162	1	the	the	DET
admet-2268	162	2	sink	sink	NOUN
admet-2268	162	3	condition	condition	NOUN
admet-2268	162	4	was	be	AUX
admet-2268	162	5	maintained	maintain	VERB
admet-2268	162	6	by	by	ADP
admet-2268	162	7	adding	add	VERB
admet-2268	162	8	2	2	NUM
admet-2268	162	9	ml	ml	NOUN
admet-2268	162	10	of	of	ADP
admet-2268	162	11	fresh	fresh	ADJ
admet-2268	162	12	buffer	buffer	NOUN
admet-2268	162	13	solution	solution	NOUN
admet-2268	162	14	immediately	immediately	ADV
admet-2268	162	15	after	after	ADP
admet-2268	162	16	each	each	DET
admet-2268	162	17	sampling	sampling	NOUN
admet-2268	162	18	.	.	PUNCT
admet-2268	163	1	sample	sample	NOUN
admet-2268	163	2	analysis	analysis	NOUN
admet-2268	163	3	was	be	AUX
admet-2268	163	4	done	do	VERB
admet-2268	163	5	in	in	ADP
admet-2268	163	6	triplicate	triplicate	NOUN
admet-2268	163	7	at	at	ADP
admet-2268	163	8	340	340	NUM
admet-2268	163	9	and	and	CCONJ
admet-2268	163	10	258	258	NUM
admet-2268	163	11	nm	nm	NOUN
admet-2268	163	12	for	for	ADP
admet-2268	163	13	berberine	berberine	NOUN
admet-2268	163	14	hcl	hcl	PROPN
admet-2268	163	15	and	and	CCONJ
admet-2268	163	16	diacerein	diacerein	ADJ
admet-2268	163	17	,	,	PUNCT
admet-2268	163	18	respectively	respectively	ADV
admet-2268	163	19	.	.	PUNCT
admet-2268	164	1	the	the	DET
admet-2268	164	2	cumulative	cumulative	ADJ
admet-2268	164	3	drug	drug	NOUN
admet-2268	164	4	permeation	permeation	NOUN
admet-2268	164	5	was	be	AUX
admet-2268	164	6	calculated	calculate	VERB
admet-2268	164	7	according	accord	VERB
admet-2268	164	8	to	to	ADP
admet-2268	164	9	the	the	DET
admet-2268	164	10	skin	skin	NOUN
admet-2268	164	11	surface	surface	NOUN
admet-2268	164	12	area	area	NOUN
admet-2268	164	13	against	against	ADP
admet-2268	164	14	time	time	NOUN
admet-2268	164	15	to	to	PART
admet-2268	164	16	estimate	estimate	VERB
admet-2268	164	17	the	the	DET
admet-2268	164	18	permeability	permeability	NOUN
admet-2268	164	19	coefficient	coefficient	NOUN
admet-2268	164	20	and	and	CCONJ
admet-2268	164	21	flux	flux	PROPN
admet-2268	164	22	jss	jss	PROPN
admet-2268	164	23	(	(	PUNCT
admet-2268	164	24	µg	µg	ADV
admet-2268	164	25	cm-2	cm-2	NOUN
admet-2268	164	26	h-1	h-1	PRON
admet-2268	164	27	)	)	PUNCT
admet-2268	165	1	[	[	X
admet-2268	165	2	21	21	NUM
admet-2268	165	3	]	]	PUNCT
admet-2268	165	4	.	.	PUNCT
admet-2268	166	1	raman	raman	VERB
admet-2268	166	2	analysis	analysis	NOUN
admet-2268	166	3	for	for	ADP
admet-2268	166	4	in	in	ADP
admet-2268	166	5	vitro	vitro	X
admet-2268	166	6	permeation	permeation	NOUN
admet-2268	166	7	studies	study	NOUN
admet-2268	166	8	,	,	PUNCT
admet-2268	166	9	optimized	optimize	VERB
admet-2268	166	10	formulation	formulation	NOUN
admet-2268	166	11	,	,	PUNCT
admet-2268	166	12	pig	pig	NOUN
admet-2268	166	13	skin	skin	NOUN
admet-2268	166	14	,	,	PUNCT
admet-2268	166	15	and	and	CCONJ
admet-2268	166	16	pig	pig	NOUN
admet-2268	166	17	skin	skin	NOUN
admet-2268	166	18	containing	contain	VERB
admet-2268	166	19	optimized	optimize	VERB
admet-2268	166	20	formulation	formulation	NOUN
admet-2268	166	21	samples	sample	NOUN
admet-2268	166	22	were	be	AUX
admet-2268	166	23	analyzed	analyze	VERB
admet-2268	166	24	to	to	PART
admet-2268	166	25	see	see	VERB
admet-2268	166	26	how	how	SCONJ
admet-2268	166	27	well	well	ADV
admet-2268	166	28	the	the	DET
admet-2268	166	29	formulation	formulation	NOUN
admet-2268	166	30	could	could	AUX
admet-2268	166	31	pass	pass	VERB
admet-2268	166	32	through	through	ADP
admet-2268	166	33	the	the	DET
admet-2268	166	34	skin	skin	NOUN
admet-2268	166	35	using	use	VERB
admet-2268	166	36	direct	direct	ADJ
admet-2268	166	37	coupled	couple	VERB
admet-2268	166	38	universal	universal	ADJ
admet-2268	166	39	modular	modular	ADJ
admet-2268	166	40	raman	raman	NOUN
admet-2268	166	41	spectrometer	spectrometer	NOUN
admet-2268	166	42	with	with	ADP
admet-2268	166	43	imaging	imaging	NOUN
admet-2268	166	44	(	(	PUNCT
admet-2268	166	45	rims	rims	X
admet-2268	166	46	-	-	PUNCT
admet-2268	166	47	u	u	NOUN
admet-2268	166	48	-	-	PROPN
admet-2268	166	49	dc	dc	NOUN
admet-2268	166	50	,	,	PUNCT
admet-2268	166	51	rinztech	rinztech	VERB
admet-2268	166	52	nz	nz	PROPN
admet-2268	166	53	ltd	ltd	PROPN
admet-2268	166	54	.	.	PROPN
admet-2268	166	55	,	,	PUNCT
admet-2268	166	56	new	new	PROPN
admet-2268	166	57	zealand	zealand	PROPN
admet-2268	166	58	)	)	PUNCT
admet-2268	166	59	.	.	PUNCT
admet-2268	167	1	the	the	DET
admet-2268	167	2	pig	pig	NOUN
admet-2268	167	3	skin	skin	NOUN
admet-2268	167	4	was	be	AUX
admet-2268	167	5	mounted	mount	VERB
admet-2268	167	6	on	on	ADP
admet-2268	167	7	the	the	DET
admet-2268	167	8	glass	glass	NOUN
admet-2268	167	9	slide	slide	NOUN
admet-2268	167	10	using	use	VERB
admet-2268	167	11	forceps	forceps	NOUN
admet-2268	167	12	,	,	PUNCT
admet-2268	167	13	ensuring	ensure	VERB
admet-2268	167	14	stratum	stratum	NOUN
admet-2268	167	15	corneum	corneum	NOUN
admet-2268	167	16	facing	face	VERB
admet-2268	167	17	towards	towards	ADP
admet-2268	167	18	the	the	DET
admet-2268	167	19	lens	len	NOUN
admet-2268	167	20	.	.	PUNCT
admet-2268	168	1	the	the	DET
admet-2268	168	2	sample	sample	NOUN
admet-2268	168	3	admet	admet	PROPN
admet-2268	168	4	&	&	CCONJ
admet-2268	168	5	dmpk	dmpk	PROPN
admet-2268	168	6	12(3	12(3	PROPN
admet-2268	168	7	)	)	PUNCT
admet-2268	168	8	(	(	PUNCT
admet-2268	168	9	2024	2024	NUM
admet-2268	168	10	)	)	PUNCT
admet-2268	168	11	553	553	NUM
admet-2268	168	12	-	-	SYM
admet-2268	168	13	580	580	NUM
admet-2268	168	14	berberine	berberine	NOUN
admet-2268	168	15	hcl	hcl	PROPN
admet-2268	168	16	and	and	CCONJ
admet-2268	168	17	diacerein	diacerein	ADV
admet-2268	168	18	loaded	load	VERB
admet-2268	168	19	dual	dual	ADJ
admet-2268	168	20	delivery	delivery	NOUN
admet-2268	168	21	transferosomes	transferosome	NOUN
admet-2268	168	22	doi	doi	PROPN
admet-2268	168	23	:	:	PUNCT
admet-2268	168	24	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	168	25	559	559	NUM
admet-2268	168	26	was	be	AUX
admet-2268	168	27	observed	observe	VERB
admet-2268	168	28	at	at	ADP
admet-2268	168	29	20×	20×	NUM
admet-2268	168	30	at	at	ADP
admet-2268	168	31	785	785	NUM
admet-2268	168	32	nm	nm	NOUN
admet-2268	168	33	and	and	CCONJ
admet-2268	168	34	a	a	DET
admet-2268	168	35	laser	laser	NOUN
admet-2268	168	36	power	power	NOUN
admet-2268	168	37	of	of	ADP
admet-2268	168	38	300	300	NUM
admet-2268	168	39	mw	mw	NOUN
admet-2268	168	40	,	,	PUNCT
admet-2268	168	41	followed	follow	VERB
admet-2268	168	42	by	by	ADP
admet-2268	168	43	laser	laser	NOUN
admet-2268	168	44	stability	stability	NOUN
admet-2268	168	45	of	of	ADP
admet-2268	168	46	1	1	NUM
admet-2268	168	47	%	%	NOUN
admet-2268	168	48	.	.	PUNCT
admet-2268	169	1	in	in	ADP
admet-2268	169	2	addition	addition	NOUN
admet-2268	169	3	,	,	PUNCT
admet-2268	169	4	all	all	DET
admet-2268	169	5	the	the	DET
admet-2268	169	6	other	other	ADJ
admet-2268	169	7	pig	pig	NOUN
admet-2268	169	8	skin	skin	NOUN
admet-2268	169	9	samples	sample	NOUN
admet-2268	169	10	were	be	AUX
admet-2268	169	11	analyzed	analyze	VERB
admet-2268	169	12	under	under	ADP
admet-2268	169	13	the	the	DET
admet-2268	169	14	same	same	ADJ
admet-2268	169	15	conditions	condition	NOUN
admet-2268	169	16	,	,	PUNCT
admet-2268	169	17	and	and	CCONJ
admet-2268	169	18	data	datum	NOUN
admet-2268	169	19	were	be	AUX
admet-2268	169	20	obtained	obtain	VERB
admet-2268	169	21	,	,	PUNCT
admet-2268	169	22	analyzed	analyze	VERB
admet-2268	169	23	,	,	PUNCT
admet-2268	169	24	and	and	CCONJ
admet-2268	169	25	reported	report	VERB
admet-2268	169	26	[	[	X
admet-2268	169	27	25	25	NUM
admet-2268	169	28	]	]	PUNCT
admet-2268	169	29	.	.	PUNCT
admet-2268	170	1	skin	skin	NOUN
admet-2268	170	2	irritation	irritation	NOUN
admet-2268	170	3	test	test	VERB
admet-2268	170	4	a	a	DET
admet-2268	170	5	skin	skin	NOUN
admet-2268	170	6	safety	safety	NOUN
admet-2268	170	7	study	study	NOUN
admet-2268	170	8	was	be	AUX
admet-2268	170	9	carried	carry	VERB
admet-2268	170	10	out	out	ADP
admet-2268	170	11	using	use	VERB
admet-2268	170	12	shaved	shave	VERB
admet-2268	170	13	and	and	CCONJ
admet-2268	170	14	excised	excise	VERB
admet-2268	170	15	dorsal	dorsal	NOUN
admet-2268	170	16	skin	skin	NOUN
admet-2268	170	17	(	(	PUNCT
admet-2268	170	18	2	2	NUM
admet-2268	170	19	cm2	cm2	NOUN
admet-2268	170	20	)	)	PUNCT
admet-2268	170	21	of	of	ADP
admet-2268	170	22	male	male	ADJ
admet-2268	170	23	balb	balb	NOUN
admet-2268	170	24	/	/	SYM
admet-2268	170	25	c	c	NOUN
admet-2268	170	26	mice	mouse	NOUN
admet-2268	170	27	(	(	PUNCT
admet-2268	170	28	10	10	NUM
admet-2268	170	29	weeks	week	NOUN
admet-2268	170	30	old	old	ADJ
admet-2268	170	31	,	,	PUNCT
admet-2268	170	32	20	20	NUM
admet-2268	170	33	to	to	PART
admet-2268	170	34	22	22	NUM
admet-2268	170	35	g	g	NOUN
admet-2268	170	36	)	)	PUNCT
admet-2268	170	37	.	.	PUNCT
admet-2268	171	1	the	the	DET
admet-2268	171	2	study	study	NOUN
admet-2268	171	3	protocol	protocol	NOUN
admet-2268	171	4	was	be	AUX
admet-2268	171	5	approved	approve	VERB
admet-2268	171	6	by	by	ADP
admet-2268	171	7	the	the	DET
admet-2268	171	8	institutional	institutional	ADJ
admet-2268	171	9	animal	animal	NOUN
admet-2268	171	10	ethics	ethic	NOUN
admet-2268	171	11	committee	committee	NOUN
admet-2268	171	12	of	of	ADP
admet-2268	171	13	central	central	ADJ
admet-2268	171	14	animal	animal	PROPN
admet-2268	171	15	house	house	PROPN
admet-2268	171	16	facility	facility	NOUN
admet-2268	171	17	upes	upe	NOUN
admet-2268	171	18	university	university	PROPN
admet-2268	171	19	,	,	PUNCT
admet-2268	171	20	dehradun	dehradun	PROPN
admet-2268	171	21	,	,	PUNCT
admet-2268	171	22	india	india	PROPN
admet-2268	171	23	(	(	PUNCT
admet-2268	171	24	upes	upe	NOUN
admet-2268	171	25	/	/	SYM
admet-2268	171	26	iaec/2023/3/07	iaec/2023/3/07	VERB
admet-2268	171	27	dated	date	VERB
admet-2268	171	28	20/12/2023	20/12/2023	NUM
admet-2268	171	29	)	)	PUNCT
admet-2268	171	30	.	.	PUNCT
admet-2268	172	1	psoriasis	psoriasis	NOUN
admet-2268	172	2	was	be	AUX
admet-2268	172	3	induced	induce	VERB
admet-2268	172	4	by	by	ADP
admet-2268	172	5	applying	apply	VERB
admet-2268	172	6	62.5	62.5	NUM
admet-2268	172	7	mg	mg	NOUN
admet-2268	172	8	day-1	day-1	NUM
admet-2268	172	9	of	of	ADP
admet-2268	172	10	imiquimod	imiquimod	ADJ
admet-2268	172	11	cream	cream	NOUN
admet-2268	172	12	(	(	PUNCT
admet-2268	172	13	imiquad	imiquad	NOUN
admet-2268	172	14	®	®	NOUN
admet-2268	172	15	cream	cream	NOUN
admet-2268	172	16	,	,	PUNCT
admet-2268	172	17	glenmark	glenmark	ADJ
admet-2268	172	18	pharmaceuticals	pharmaceutical	NOUN
admet-2268	172	19	,	,	PUNCT
admet-2268	172	20	mumbai	mumbai	PROPN
admet-2268	172	21	,	,	PUNCT
admet-2268	172	22	india	india	PROPN
admet-2268	172	23	)	)	PUNCT
admet-2268	172	24	to	to	ADP
admet-2268	172	25	the	the	DET
admet-2268	172	26	skin	skin	NOUN
admet-2268	172	27	for	for	ADP
admet-2268	172	28	6	6	NUM
admet-2268	172	29	consecutive	consecutive	ADJ
admet-2268	172	30	days	day	NOUN
admet-2268	172	31	.	.	PUNCT
admet-2268	173	1	optimized	optimize	VERB
admet-2268	173	2	transferosomes	transferosome	NOUN
admet-2268	173	3	(	(	PUNCT
admet-2268	173	4	formulation	formulation	NOUN
admet-2268	173	5	ddt-10	ddt-10	VERB
admet-2268	173	6	)	)	PUNCT
admet-2268	173	7	and	and	CCONJ
admet-2268	173	8	normal	normal	ADJ
admet-2268	173	9	saline	saline	NOUN
admet-2268	173	10	as	as	ADP
admet-2268	173	11	reference	reference	NOUN
admet-2268	173	12	were	be	AUX
admet-2268	173	13	applied	apply	VERB
admet-2268	173	14	separately	separately	ADV
admet-2268	173	15	onto	onto	ADP
admet-2268	173	16	the	the	DET
admet-2268	173	17	depilated	depilated	ADJ
admet-2268	173	18	dorsal	dorsal	NOUN
admet-2268	173	19	skin	skin	NOUN
admet-2268	173	20	of	of	ADP
admet-2268	173	21	mice	mouse	NOUN
admet-2268	173	22	from	from	ADP
admet-2268	173	23	day	day	NOUN
admet-2268	173	24	3	3	NUM
admet-2268	173	25	to	to	ADP
admet-2268	173	26	day	day	NOUN
admet-2268	173	27	6	6	NUM
admet-2268	173	28	[	[	SYM
admet-2268	173	29	26	26	NUM
admet-2268	173	30	]	]	PUNCT
admet-2268	173	31	.	.	PUNCT
admet-2268	174	1	the	the	DET
admet-2268	174	2	skin	skin	NOUN
admet-2268	174	3	was	be	AUX
admet-2268	174	4	observed	observe	VERB
admet-2268	174	5	for	for	ADP
admet-2268	174	6	any	any	DET
admet-2268	174	7	evident	evident	ADJ
admet-2268	174	8	transformation	transformation	NOUN
admet-2268	174	9	on	on	ADP
admet-2268	174	10	day	day	NOUN
admet-2268	174	11	7	7	NUM
admet-2268	174	12	by	by	ADP
admet-2268	174	13	visual	visual	ADJ
admet-2268	174	14	scoring	scoring	NOUN
admet-2268	174	15	using	use	VERB
admet-2268	174	16	the	the	DET
admet-2268	174	17	modified	modify	VERB
admet-2268	174	18	draize	draize	NOUN
admet-2268	174	19	method	method	NOUN
admet-2268	174	20	.	.	PUNCT
admet-2268	175	1	the	the	DET
admet-2268	175	2	erythema	erythema	ADJ
admet-2268	175	3	scores	score	NOUN
admet-2268	175	4	were	be	AUX
admet-2268	175	5	graded	grade	VERB
admet-2268	175	6	from	from	ADP
admet-2268	175	7	0	0	NUM
admet-2268	175	8	to	to	ADP
admet-2268	175	9	4	4	NUM
admet-2268	175	10	as	as	SCONJ
admet-2268	175	11	follows	follow	VERB
admet-2268	175	12	:	:	PUNCT
admet-2268	175	13	0	0	NUM
admet-2268	175	14	with	with	ADP
admet-2268	175	15	no	no	DET
admet-2268	175	16	sign	sign	NOUN
admet-2268	175	17	of	of	ADP
admet-2268	175	18	redness	redness	NOUN
admet-2268	175	19	;	;	PUNCT
admet-2268	175	20	1	1	NUM
admet-2268	175	21	with	with	ADP
admet-2268	175	22	trial	trial	NOUN
admet-2268	175	23	erythema	erythema	NOUN
admet-2268	175	24	(	(	PUNCT
admet-2268	175	25	hardly	hardly	ADV
admet-2268	175	26	seeming	seem	VERB
admet-2268	175	27	light	light	NOUN
admet-2268	175	28	pink	pink	ADJ
admet-2268	175	29	)	)	PUNCT
admet-2268	175	30	,	,	PUNCT
admet-2268	175	31	2	2	NUM
admet-2268	175	32	with	with	ADP
admet-2268	175	33	moderate	moderate	ADJ
admet-2268	175	34	erythema	erythema	NOUN
admet-2268	175	35	(	(	PUNCT
admet-2268	175	36	dusky	dusky	ADV
admet-2268	175	37	pink	pink	ADJ
admet-2268	175	38	)	)	PUNCT
admet-2268	175	39	,	,	PUNCT
admet-2268	175	40	3	3	NUM
admet-2268	175	41	with	with	ADP
admet-2268	175	42	moderate	moderate	ADJ
admet-2268	175	43	to	to	PART
admet-2268	175	44	high	high	ADJ
admet-2268	175	45	erythema	erythema	NOUN
admet-2268	175	46	(	(	PUNCT
admet-2268	175	47	bright	bright	ADJ
admet-2268	175	48	red	red	NOUN
admet-2268	175	49	)	)	PUNCT
admet-2268	175	50	,	,	PUNCT
admet-2268	175	51	and	and	CCONJ
admet-2268	175	52	4	4	NUM
admet-2268	175	53	high	high	ADJ
admet-2268	175	54	levels	level	NOUN
admet-2268	175	55	of	of	ADP
admet-2268	175	56	erythema	erythema	ADJ
admet-2268	175	57	(	(	PUNCT
admet-2268	175	58	dark	dark	ADJ
admet-2268	175	59	red	red	NOUN
admet-2268	175	60	)	)	PUNCT
admet-2268	176	1	[	[	X
admet-2268	176	2	27	27	NUM
admet-2268	176	3	]	]	PUNCT
admet-2268	176	4	.	.	PUNCT
admet-2268	177	1	stability	stability	NOUN
admet-2268	177	2	studies	study	VERB
admet-2268	177	3	the	the	DET
admet-2268	177	4	optimized	optimize	VERB
admet-2268	177	5	formulation	formulation	NOUN
admet-2268	177	6	was	be	AUX
admet-2268	177	7	subjected	subject	VERB
admet-2268	177	8	to	to	ADP
admet-2268	177	9	stability	stability	NOUN
admet-2268	177	10	assessment	assessment	NOUN
admet-2268	177	11	at	at	ADP
admet-2268	177	12	different	different	ADJ
admet-2268	177	13	storage	storage	NOUN
admet-2268	177	14	conditions	condition	NOUN
admet-2268	177	15	,	,	PUNCT
admet-2268	177	16	such	such	ADJ
admet-2268	177	17	as	as	ADP
admet-2268	177	18	4±1	4±1	NUM
admet-2268	177	19	°	°	ADP
admet-2268	177	20	c	c	NOUN
admet-2268	177	21	and	and	CCONJ
admet-2268	177	22	25±2	25±2	NUM
admet-2268	177	23	°	°	ADP
admet-2268	177	24	c	c	NOUN
admet-2268	177	25	/	/	SYM
admet-2268	177	26	60±5	60±5	NOUN
admet-2268	177	27	%	%	NOUN
admet-2268	177	28	of	of	ADP
admet-2268	177	29	relative	relative	ADJ
admet-2268	177	30	humidity	humidity	NOUN
admet-2268	177	31	(	(	PUNCT
admet-2268	177	32	rh	rh	PROPN
admet-2268	177	33	)	)	PUNCT
admet-2268	177	34	for	for	ADP
admet-2268	177	35	3	3	NUM
admet-2268	177	36	months	month	NOUN
admet-2268	177	37	was	be	AUX
admet-2268	177	38	carried	carry	VERB
admet-2268	177	39	out	out	ADP
admet-2268	177	40	[	[	X
admet-2268	177	41	28	28	NUM
admet-2268	177	42	]	]	PUNCT
admet-2268	177	43	.	.	PUNCT
admet-2268	178	1	the	the	DET
admet-2268	178	2	results	result	NOUN
admet-2268	178	3	of	of	ADP
admet-2268	178	4	the	the	DET
admet-2268	178	5	stability	stability	NOUN
admet-2268	178	6	study	study	NOUN
admet-2268	178	7	were	be	AUX
admet-2268	178	8	reported	report	VERB
admet-2268	178	9	in	in	ADP
admet-2268	178	10	terms	term	NOUN
admet-2268	178	11	of	of	ADP
admet-2268	178	12	physical	physical	ADJ
admet-2268	178	13	appearance	appearance	NOUN
admet-2268	178	14	,	,	PUNCT
admet-2268	178	15	vesicle	vesicle	NOUN
admet-2268	178	16	size	size	NOUN
admet-2268	178	17	,	,	PUNCT
admet-2268	178	18	morphology	morphology	NOUN
admet-2268	178	19	,	,	PUNCT
admet-2268	178	20	and	and	CCONJ
admet-2268	178	21	zeta	zeta	NOUN
admet-2268	178	22	potential	potential	NOUN
admet-2268	178	23	.	.	PUNCT
admet-2268	179	1	results	result	NOUN
admet-2268	179	2	and	and	CCONJ
admet-2268	179	3	discussion	discussion	NOUN
admet-2268	179	4	optimization	optimization	NOUN
admet-2268	179	5	studies	study	NOUN
admet-2268	179	6	the	the	DET
admet-2268	179	7	dual	dual	ADJ
admet-2268	179	8	delivery	delivery	NOUN
admet-2268	179	9	loaded	load	VERB
admet-2268	179	10	transferosomes	transferosome	NOUN
admet-2268	179	11	were	be	AUX
admet-2268	179	12	prepared	prepare	VERB
admet-2268	179	13	using	use	VERB
admet-2268	179	14	the	the	DET
admet-2268	179	15	thin	thin	ADJ
admet-2268	179	16	film	film	NOUN
admet-2268	179	17	hydration	hydration	NOUN
admet-2268	179	18	method	method	NOUN
admet-2268	179	19	and	and	CCONJ
admet-2268	179	20	optimized	optimize	VERB
admet-2268	179	21	using	use	VERB
admet-2268	179	22	the	the	DET
admet-2268	179	23	box	box	NOUN
admet-2268	179	24	-	-	PUNCT
admet-2268	179	25	behnken	behnken	VERB
admet-2268	179	26	design	design	NOUN
admet-2268	179	27	.	.	PUNCT
admet-2268	180	1	three	three	NUM
admet-2268	180	2	independent	independent	ADJ
admet-2268	180	3	variables	variable	NOUN
admet-2268	180	4	,	,	PUNCT
admet-2268	180	5	a	a	DET
admet-2268	180	6	,	,	PUNCT
admet-2268	180	7	b	b	NOUN
admet-2268	180	8	and	and	CCONJ
admet-2268	180	9	c	c	NOUN
admet-2268	180	10	,	,	PUNCT
admet-2268	180	11	were	be	AUX
admet-2268	180	12	used	use	VERB
admet-2268	180	13	to	to	PART
admet-2268	180	14	build	build	VERB
admet-2268	180	15	a	a	DET
admet-2268	180	16	significant	significant	ADJ
admet-2268	180	17	model	model	NOUN
admet-2268	180	18	in	in	ADP
admet-2268	180	19	the	the	DET
admet-2268	180	20	boxbehnken	boxbehnken	VERB
admet-2268	180	21	design	design	NOUN
admet-2268	180	22	.	.	PUNCT
admet-2268	181	1	the	the	DET
admet-2268	181	2	interactions	interaction	NOUN
admet-2268	181	3	between	between	ADP
admet-2268	181	4	individual	individual	ADJ
admet-2268	181	5	variables	variable	NOUN
admet-2268	181	6	and	and	CCONJ
admet-2268	181	7	their	their	PRON
admet-2268	181	8	effects	effect	NOUN
admet-2268	181	9	on	on	ADP
admet-2268	181	10	experimental	experimental	ADJ
admet-2268	181	11	responses	response	NOUN
admet-2268	181	12	i.e.	i.e.	X
admet-2268	181	13	,	,	PUNCT
admet-2268	181	14	vesicle	vesicle	NOUN
admet-2268	181	15	size	size	NOUN
admet-2268	181	16	and	and	CCONJ
admet-2268	181	17	entrapment	entrapment	ADJ
admet-2268	181	18	efficiency	efficiency	NOUN
admet-2268	181	19	,	,	PUNCT
admet-2268	181	20	were	be	AUX
admet-2268	181	21	optimized	optimize	VERB
admet-2268	181	22	using	use	VERB
admet-2268	181	23	a	a	DET
admet-2268	181	24	3	3	NUM
admet-2268	181	25	-	-	PUNCT
admet-2268	181	26	level	level	NOUN
admet-2268	181	27	factorial	factorial	NOUN
admet-2268	181	28	design	design	NOUN
admet-2268	181	29	(	(	PUNCT
admet-2268	181	30	tables	table	NOUN
admet-2268	181	31	1	1	NUM
admet-2268	181	32	and	and	CCONJ
admet-2268	181	33	2	2	NUM
admet-2268	181	34	)	)	PUNCT
admet-2268	181	35	.	.	PUNCT
admet-2268	182	1	the	the	DET
admet-2268	182	2	model	model	NOUN
admet-2268	182	3	's	's	PART
admet-2268	182	4	significance	significance	NOUN
admet-2268	182	5	was	be	AUX
admet-2268	182	6	determined	determine	VERB
admet-2268	182	7	based	base	VERB
admet-2268	182	8	on	on	ADP
admet-2268	182	9	statistical	statistical	ADJ
admet-2268	182	10	parameters	parameter	NOUN
admet-2268	182	11	comprising	comprise	VERB
admet-2268	182	12	the	the	DET
admet-2268	182	13	anova	anova	PROPN
admet-2268	182	14	and	and	CCONJ
admet-2268	182	15	regression	regression	VERB
admet-2268	182	16	coefficient	coefficient	NOUN
admet-2268	182	17	(	(	PUNCT
admet-2268	182	18	r2	r2	PROPN
admet-2268	182	19	)	)	PUNCT
admet-2268	182	20	test	test	NOUN
admet-2268	182	21	.	.	PUNCT
admet-2268	183	1	formulation	formulation	NOUN
admet-2268	183	2	ddt-10	ddt-10	ADP
admet-2268	183	3	(	(	PUNCT
admet-2268	183	4	85	85	NUM
admet-2268	183	5	:	:	SYM
admet-2268	183	6	15	15	NUM
admet-2268	183	7	ratio	ratio	NOUN
admet-2268	183	8	of	of	ADP
admet-2268	183	9	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	183	10	(	(	PUNCT
admet-2268	183	11	a	a	NOUN
admet-2268	183	12	)	)	PUNCT
admet-2268	183	13	and	and	CCONJ
admet-2268	183	14	sodium	sodium	NOUN
admet-2268	183	15	deoxycholate	deoxycholate	VERB
admet-2268	183	16	(	(	PUNCT
admet-2268	183	17	b	b	NOUN
admet-2268	183	18	)	)	PUNCT
admet-2268	183	19	at	at	ADP
admet-2268	183	20	3	3	NUM
admet-2268	183	21	min	min	NOUN
admet-2268	183	22	sonication	sonication	NOUN
admet-2268	183	23	time	time	NOUN
admet-2268	183	24	(	(	PUNCT
admet-2268	183	25	c	c	NOUN
admet-2268	183	26	)	)	PUNCT
admet-2268	183	27	was	be	AUX
admet-2268	183	28	found	find	VERB
admet-2268	183	29	as	as	ADP
admet-2268	183	30	an	an	DET
admet-2268	183	31	optimized	optimize	VERB
admet-2268	183	32	formulation	formulation	NOUN
admet-2268	183	33	(	(	PUNCT
admet-2268	183	34	tables	table	NOUN
admet-2268	183	35	1	1	NUM
admet-2268	183	36	and	and	CCONJ
admet-2268	183	37	2	2	NUM
admet-2268	183	38	)	)	PUNCT
admet-2268	183	39	.	.	PUNCT
admet-2268	184	1	table	table	NOUN
admet-2268	185	1	2	2	NUM
admet-2268	185	2	.	.	PUNCT
admet-2268	185	3	results	result	NOUN
admet-2268	185	4	of	of	ADP
admet-2268	185	5	berberine	berberine	NOUN
admet-2268	185	6	hcl	hcl	PROPN
admet-2268	185	7	and	and	CCONJ
admet-2268	185	8	diacerein	diacerein	ADV
admet-2268	185	9	loaded	load	VERB
admet-2268	185	10	dual	dual	ADJ
admet-2268	185	11	delivery	delivery	NOUN
admet-2268	185	12	transferosomes	transferosome	NOUN
admet-2268	185	13	.	.	PUNCT
admet-2268	186	1	formulation	formulation	NOUN
admet-2268	186	2	code	code	NOUN
admet-2268	186	3	particle	particle	NOUN
admet-2268	186	4	size	size	NOUN
admet-2268	186	5	,	,	PUNCT
admet-2268	186	6	nm	nm	ADJ
admet-2268	186	7	entrapment	entrapment	ADJ
admet-2268	186	8	efficiency	efficiency	NOUN
admet-2268	186	9	,	,	PUNCT
admet-2268	186	10	%	%	NOUN
admet-2268	186	11	drug	drug	NOUN
admet-2268	186	12	loading	loading	NOUN
admet-2268	186	13	,	,	PUNCT
admet-2268	186	14	%	%	INTJ
admet-2268	186	15	deformability	deformability	NOUN
admet-2268	186	16	,	,	PUNCT
admet-2268	186	17	%	%	NOUN
admet-2268	186	18	berberine	berberine	PROPN
admet-2268	186	19	hcl	hcl	PROPN
admet-2268	186	20	diacerein	diacerein	PROPN
admet-2268	186	21	berberine	berberine	PROPN
admet-2268	186	22	hcl	hcl	PROPN
admet-2268	186	23	diacerein	diacerein	ADV
admet-2268	186	24	ddt-1	ddt-1	CCONJ
admet-2268	186	25	95.93	95.93	NUM
admet-2268	186	26	±2.5	±2.5	PROPN
admet-2268	187	1	69.14±1.4	69.14±1.4	PROPN
admet-2268	187	2	71.32±2.2	71.32±2.2	PROPN
admet-2268	187	3	12.94±0.03	12.94±0.03	NUM
admet-2268	187	4	15.03±0.65	15.03±0.65	NUM
admet-2268	187	5	8.47±0.02	8.47±0.02	PROPN
admet-2268	187	6	ddt-2	ddt-2	NUM
admet-2268	187	7	118.45±1.4	118.45±1.4	NUM
admet-2268	188	1	65.30±1.7	65.30±1.7	NUM
admet-2268	188	2	72.34±1.4	72.34±1.4	NUM
admet-2268	188	3	12.70±0.24	12.70±0.24	NUM
admet-2268	188	4	15.09±0.39	15.09±0.39	NUM
admet-2268	188	5	13.11±0.09	13.11±0.09	NUM
admet-2268	188	6	ddt-3	ddt-3	PRON
admet-2268	188	7	103.00±1.2	103.00±1.2	NOUN
admet-2268	189	1	62.11±1.4	62.11±1.4	PRON
admet-2268	189	2	66.61±1.5	66.61±1.5	NUM
admet-2268	189	3	12.35±0.11	12.35±0.11	NUM
admet-2268	189	4	14.59±0.02	14.59±0.02	NUM
admet-2268	189	5	10.79±0.19	10.79±0.19	NUM
admet-2268	189	6	ddt-4	ddt-4	X
admet-2268	189	7	114.60±3.5	114.60±3.5	NUM
admet-2268	190	1	59.24±1.5	59.24±1.5	NUM
admet-2268	190	2	64.87±1.6	64.87±1.6	PROPN
admet-2268	190	3	12.04±0.02	12.04±0.02	NUM
admet-2268	190	4	14.47±0.20	14.47±0.20	NUM
admet-2268	190	5	12.97±0.02	12.97±0.02	NUM
admet-2268	190	6	ddt-5	ddt-5	NUM
admet-2268	190	7	104.50±2.2	104.50±2.2	NUM
admet-2268	190	8	85.73±1.5	85.73±1.5	PROPN
admet-2268	190	9	88.22±1.8	88.22±1.8	PROPN
admet-2268	190	10	17.05±0.07	17.05±0.07	NUM
admet-2268	190	11	19.37±0.36	19.37±0.36	NUM
admet-2268	190	12	11.47±0.36	11.47±0.36	NUM
admet-2268	190	13	ddt-6	ddt-6	NOUN
admet-2268	190	14	90.80±2.7	90.80±2.7	NUM
admet-2268	190	15	68.32±2.4	68.32±2.4	NUM
admet-2268	190	16	65.51±1.2	65.51±1.2	NUM
admet-2268	190	17	12.90±0.07	12.90±0.07	PROPN
admet-2268	190	18	14.51±0.14	14.51±0.14	NUM
admet-2268	190	19	8.35±0.18	8.35±0.18	NUM
admet-2268	190	20	ddt-7	ddt-7	NUM
admet-2268	190	21	99.90±1.6	99.90±1.6	NUM
admet-2268	191	1	64.51±1.6	64.51±1.6	NUM
admet-2268	191	2	69.11±2.1	69.11±2.1	NUM
admet-2268	191	3	12.50±0.04	12.50±0.04	NUM
admet-2268	191	4	15.07±0.05	15.07±0.05	NUM
admet-2268	191	5	9.78±0.12	9.78±0.12	NUM
admet-2268	191	6	ddt-8	ddt-8	NUM
admet-2268	191	7	119.00±2.8	119.00±2.8	NOUN
admet-2268	191	8	72.11±2.1	72.11±2.1	NUM
admet-2268	191	9	84.09±1.4	84.09±1.4	ADJ
admet-2268	191	10	15.7±0.19	15.7±0.19	NUM
admet-2268	191	11	18.96±0.16	18.96±0.16	NUM
admet-2268	191	12	14.51±0.12	14.51±0.12	NUM
admet-2268	191	13	ddt-9	ddt-9	NUM
admet-2268	191	14	106.90±2.6	106.90±2.6	NUM
admet-2268	191	15	60.27±1.4	60.27±1.4	PROPN
admet-2268	191	16	61.15±1.4	61.15±1.4	NUM
admet-2268	191	17	12.16±0.09	12.16±0.09	NUM
admet-2268	191	18	14.40±0.07	14.40±0.07	NUM
admet-2268	191	19	10.80±0.11	10.80±0.11	NUM
admet-2268	191	20	ddt-10	ddt-10	VERB
admet-2268	191	21	110.90±2.8	110.90±2.8	ADJ
admet-2268	191	22	89.50±1.5	89.50±1.5	PROPN
admet-2268	191	23	91.23±1.8	91.23±1.8	NUM
admet-2268	191	24	19.41±0.47	19.41±0.47	NUM
admet-2268	191	25	21.91±0.05	21.91±0.05	NUM
admet-2268	191	26	12.44±0.39	12.44±0.39	PROPN
admet-2268	191	27	ddt-11	ddt-11	NUM
admet-2268	191	28	115.00±1.6	115.00±1.6	NUM
admet-2268	191	29	75.42±1.2	75.42±1.2	NUM
admet-2268	191	30	74.42±1.5	74.42±1.5	NOUN
admet-2268	191	31	16.17±0.06	16.17±0.06	NUM
admet-2268	191	32	15.90±0.65	15.90±0.65	NUM
admet-2268	191	33	13.34±0.25	13.34±0.25	PROPN
admet-2268	191	34	ddt-12	ddt-12	NOUN
admet-2268	191	35	86.98±2.4	86.98±2.4	NUM
admet-2268	191	36	66.16±2.4	66.16±2.4	NUM
admet-2268	191	37	68.61±2.3	68.61±2.3	NUM
admet-2268	191	38	12.77±0.02	12.77±0.02	NUM
admet-2268	191	39	14.98±0.28	14.98±0.28	NOUN
admet-2268	191	40	7.43±0.04	7.43±0.04	NOUN
admet-2268	191	41	ddt-13	ddt-13	NUM
admet-2268	191	42	121.45±2.5	121.45±2.5	NUM
admet-2268	191	43	76.00±1.2	76.00±1.2	NUM
admet-2268	191	44	82.32±1.5	82.32±1.5	NUM
admet-2268	191	45	16.70±0.21	16.70±0.21	PROPN
admet-2268	191	46	18.22±0.07	18.22±0.07	NUM
admet-2268	191	47	14.15±0.08	14.15±0.08	NUM
admet-2268	191	48	the	the	DET
admet-2268	191	49	study	study	NOUN
admet-2268	191	50	investigated	investigate	VERB
admet-2268	191	51	the	the	DET
admet-2268	191	52	impact	impact	NOUN
admet-2268	191	53	of	of	ADP
admet-2268	191	54	independent	independent	ADJ
admet-2268	191	55	variables	variable	NOUN
admet-2268	191	56	on	on	ADP
admet-2268	191	57	the	the	DET
admet-2268	191	58	particle	particle	NOUN
admet-2268	191	59	size	size	NOUN
admet-2268	191	60	and	and	CCONJ
admet-2268	191	61	entrapment	entrapment	ADJ
admet-2268	191	62	efficiency	efficiency	NOUN
admet-2268	191	63	of	of	ADP
admet-2268	191	64	dual	dual	ADV
admet-2268	191	65	-	-	PUNCT
admet-2268	191	66	loaded	load	VERB
admet-2268	191	67	drugs	drug	NOUN
admet-2268	191	68	(	(	PUNCT
admet-2268	191	69	table	table	NOUN
admet-2268	191	70	2	2	NUM
admet-2268	191	71	)	)	PUNCT
admet-2268	191	72	.	.	PUNCT
admet-2268	192	1	contour	contour	NOUN
admet-2268	192	2	plots	plot	NOUN
admet-2268	192	3	and	and	CCONJ
admet-2268	192	4	3d	3d	NUM
admet-2268	192	5	response	response	NOUN
admet-2268	192	6	plots	plot	NOUN
admet-2268	192	7	are	be	AUX
admet-2268	192	8	shown	show	VERB
admet-2268	192	9	in	in	ADP
admet-2268	192	10	figure	figure	NOUN
admet-2268	192	11	1	1	NUM
admet-2268	192	12	.	.	PUNCT
admet-2268	193	1	the	the	DET
admet-2268	193	2	quadratic	quadratic	ADJ
admet-2268	193	3	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	193	4	s.	s.	PROPN
admet-2268	193	5	singh	singh	PROPN
admet-2268	193	6	and	and	CCONJ
admet-2268	193	7	r.	r.	PROPN
admet-2268	193	8	awasthi	awasthi	PROPN
admet-2268	193	9	admet	admet	PROPN
admet-2268	193	10	&	&	CCONJ
admet-2268	193	11	dmpk	dmpk	PROPN
admet-2268	193	12	12(3	12(3	PROPN
admet-2268	193	13	)	)	PUNCT
admet-2268	193	14	(	(	PUNCT
admet-2268	193	15	2024	2024	NUM
admet-2268	193	16	)	)	PUNCT
admet-2268	193	17	553	553	NUM
admet-2268	193	18	-	-	SYM
admet-2268	193	19	580	580	NUM
admet-2268	193	20	560	560	NUM
admet-2268	193	21	equations	equation	NOUN
admet-2268	193	22	were	be	AUX
admet-2268	193	23	developed	develop	VERB
admet-2268	193	24	to	to	PART
admet-2268	193	25	represent	represent	VERB
admet-2268	193	26	the	the	DET
admet-2268	193	27	relationship	relationship	NOUN
admet-2268	193	28	between	between	ADP
admet-2268	193	29	the	the	DET
admet-2268	193	30	independent	independent	ADJ
admet-2268	193	31	and	and	CCONJ
admet-2268	193	32	dependent	dependent	ADJ
admet-2268	193	33	variables	variable	NOUN
admet-2268	193	34	(	(	PUNCT
admet-2268	193	35	eq	eq	NOUN
admet-2268	193	36	.	.	PROPN
admet-2268	193	37	6	6	NUM
admet-2268	193	38	8)	8)	NUM
admet-2268	193	39	.	.	PUNCT
admet-2268	194	1	y1	y1	INTJ
admet-2268	194	2	(	(	PUNCT
admet-2268	194	3	particle	particle	NOUN
admet-2268	194	4	size	size	NOUN
admet-2268	194	5	)	)	PUNCT
admet-2268	194	6	=	=	PUNCT
admet-2268	195	1	110	110	NUM
admet-2268	195	2	10.79a	10.79a	NUM
admet-2268	195	3	5.65b	5.65b	NUM
admet-2268	195	4	3.08c	3.08c	NUM
admet-2268	195	5	+	+	CCONJ
admet-2268	195	6	2.96ab	2.96ab	NUM
admet-2268	195	7	2.23ac	2.23ac	NUM
admet-2268	195	8	0.0125bc	0.0125bc	NUM
admet-2268	196	1	6.62a2	6.62a2	NUM
admet-2268	196	2	1.11b2	1.11b2	NUM
admet-2268	196	3	+	+	CCONJ
admet-2268	196	4	0.9437c2	0.9437c2	NUM
admet-2268	196	5	(	(	PUNCT
admet-2268	196	6	6	6	NUM
admet-2268	196	7	)	)	PUNCT
admet-2268	196	8	y2	y2	PROPN
admet-2268	196	9	(	(	PUNCT
admet-2268	196	10	ee	ee	PROPN
admet-2268	196	11	of	of	ADP
admet-2268	196	12	berberine	berberine	PROPN
admet-2268	196	13	hcl	hcl	PROPN
admet-2268	196	14	)	)	PUNCT
admet-2268	196	15	=	=	SYM
admet-2268	197	1	89	89	NUM
admet-2268	197	2	5.13a	5.13a	NUM
admet-2268	197	3	+	+	CCONJ
admet-2268	197	4	0.7500b	0.7500b	NOUN
admet-2268	198	1	+	+	CCONJ
admet-2268	199	1	0.1250c	0.1250c	NOUN
admet-2268	199	2	2.50ab	2.50ab	NUM
admet-2268	199	3	-0.2500ac	-0.2500ac	NOUN
admet-2268	199	4	+	+	CCONJ
admet-2268	199	5	+	+	CCONJ
admet-2268	199	6	2.00bc	2.00bc	NUM
admet-2268	199	7	3.37a2	3.37a2	NUM
admet-2268	199	8	11.12b2	11.12b2	NUM
admet-2268	199	9	-16.38c2	-16.38c2	X
admet-2268	199	10	(	(	PUNCT
admet-2268	199	11	7	7	X
admet-2268	199	12	)	)	PUNCT
admet-2268	199	13	y3	y3	NOUN
admet-2268	199	14	(	(	PUNCT
admet-2268	199	15	ee	ee	PROPN
admet-2268	199	16	of	of	ADP
admet-2268	199	17	diacerein	diacerein	ADJ
admet-2268	199	18	)	)	PUNCT
admet-2268	200	1	=	=	SYM
admet-2268	201	1	90.85	90.85	NUM
admet-2268	202	1	6.88a	6.88a	NUM
admet-2268	202	2	1.13b	1.13b	NUM
admet-2268	202	3	1.75c	1.75c	NUM
admet-2268	202	4	3.00ab	3.00ab	NUM
admet-2268	202	5	+	+	NUM
admet-2268	202	6	2.25ac	2.25ac	NOUN
admet-2268	202	7	+	+	CCONJ
admet-2268	202	8	3.25bc	3.25bc	NUM
admet-2268	202	9	3.17a2	3.17a2	NUM
admet-2268	202	10	-11.17b2	-11.17b2	NOUN
admet-2268	202	11	13.93c2	13.93c2	NUM
admet-2268	202	12	(	(	PUNCT
admet-2268	202	13	8)	8)	NUM
admet-2268	202	14	where	where	SCONJ
admet-2268	202	15	a	a	PRON
admet-2268	202	16	is	be	AUX
admet-2268	202	17	the	the	DET
admet-2268	202	18	amount	amount	NOUN
admet-2268	202	19	of	of	ADP
admet-2268	202	20	phospholipid	phospholipid	NOUN
admet-2268	202	21	,	,	PUNCT
admet-2268	202	22	b	b	PROPN
admet-2268	202	23	is	be	AUX
admet-2268	202	24	the	the	DET
admet-2268	202	25	amount	amount	NOUN
admet-2268	202	26	of	of	ADP
admet-2268	202	27	edge	edge	NOUN
admet-2268	202	28	activator	activator	NOUN
admet-2268	202	29	,	,	PUNCT
admet-2268	202	30	c	c	PROPN
admet-2268	202	31	is	be	AUX
admet-2268	202	32	the	the	DET
admet-2268	202	33	sonication	sonication	NOUN
admet-2268	202	34	cycle	cycle	NOUN
admet-2268	202	35	time	time	NOUN
admet-2268	202	36	,	,	PUNCT
admet-2268	202	37	ab	ab	PROPN
admet-2268	202	38	is	be	AUX
admet-2268	202	39	the	the	DET
admet-2268	202	40	amount	amount	NOUN
admet-2268	202	41	of	of	ADP
admet-2268	202	42	the	the	DET
admet-2268	202	43	phospholipid	phospholipid	NOUN
admet-2268	202	44	and	and	CCONJ
admet-2268	202	45	edge	edge	NOUN
admet-2268	202	46	activator	activator	NOUN
admet-2268	202	47	,	,	PUNCT
admet-2268	202	48	ac	ac	PROPN
admet-2268	202	49	is	be	AUX
admet-2268	202	50	the	the	DET
admet-2268	202	51	amount	amount	NOUN
admet-2268	202	52	of	of	ADP
admet-2268	202	53	phospholipid	phospholipid	NOUN
admet-2268	202	54	and	and	CCONJ
admet-2268	202	55	sonication	sonication	NOUN
admet-2268	202	56	cycle	cycle	NOUN
admet-2268	202	57	time	time	NOUN
admet-2268	202	58	,	,	PUNCT
admet-2268	202	59	bc	bc	PROPN
admet-2268	202	60	is	be	AUX
admet-2268	202	61	the	the	DET
admet-2268	202	62	amount	amount	NOUN
admet-2268	202	63	of	of	ADP
admet-2268	202	64	edge	edge	NOUN
admet-2268	202	65	activator	activator	NOUN
admet-2268	202	66	and	and	CCONJ
admet-2268	202	67	sonication	sonication	NOUN
admet-2268	202	68	cycle	cycle	NOUN
admet-2268	202	69	time	time	NOUN
admet-2268	202	70	.	.	PUNCT
admet-2268	203	1	the	the	DET
admet-2268	203	2	negative	negative	ADJ
admet-2268	203	3	magnitude	magnitude	NOUN
admet-2268	203	4	of	of	ADP
admet-2268	203	5	the	the	DET
admet-2268	203	6	amount	amount	NOUN
admet-2268	203	7	of	of	ADP
admet-2268	203	8	phospholipid	phospholipid	NOUN
admet-2268	203	9	reduces	reduce	VERB
admet-2268	203	10	the	the	DET
admet-2268	203	11	particle	particle	NOUN
admet-2268	203	12	size	size	NOUN
admet-2268	203	13	of	of	ADP
admet-2268	203	14	transferosomes	transferosome	NOUN
admet-2268	203	15	(	(	PUNCT
admet-2268	203	16	equation	equation	NOUN
admet-2268	203	17	(	(	PUNCT
admet-2268	203	18	6	6	NUM
admet-2268	203	19	)	)	PUNCT
admet-2268	203	20	)	)	PUNCT
admet-2268	203	21	.	.	PUNCT
admet-2268	204	1	previous	previous	ADJ
admet-2268	204	2	studies	study	NOUN
admet-2268	204	3	have	have	AUX
admet-2268	204	4	also	also	ADV
admet-2268	204	5	documented	document	VERB
admet-2268	204	6	a	a	DET
admet-2268	204	7	reduction	reduction	NOUN
admet-2268	204	8	in	in	ADP
admet-2268	204	9	vesicle	vesicle	NOUN
admet-2268	204	10	size	size	NOUN
admet-2268	204	11	at	at	ADP
admet-2268	204	12	elevated	elevated	ADJ
admet-2268	204	13	amounts	amount	NOUN
admet-2268	204	14	of	of	ADP
admet-2268	204	15	phospholipid	phospholipid	NOUN
admet-2268	204	16	[	[	X
admet-2268	204	17	29,30	29,30	NUM
admet-2268	204	18	]	]	PUNCT
admet-2268	204	19	.	.	PUNCT
admet-2268	205	1	the	the	DET
admet-2268	205	2	amount	amount	NOUN
admet-2268	205	3	of	of	ADP
admet-2268	205	4	edge	edge	NOUN
admet-2268	205	5	activator	activator	NOUN
admet-2268	205	6	(	(	PUNCT
admet-2268	205	7	sodium	sodium	NOUN
admet-2268	205	8	deoxycholate	deoxycholate	NOUN
admet-2268	205	9	)	)	PUNCT
admet-2268	205	10	also	also	ADV
admet-2268	205	11	had	have	VERB
admet-2268	205	12	a	a	DET
admet-2268	205	13	negative	negative	ADJ
admet-2268	205	14	effect	effect	NOUN
admet-2268	205	15	on	on	ADP
admet-2268	205	16	vesicle	vesicle	NOUN
admet-2268	205	17	size	size	NOUN
admet-2268	205	18	(	(	PUNCT
admet-2268	205	19	equation	equation	NOUN
admet-2268	205	20	(	(	PUNCT
admet-2268	205	21	6	6	NUM
admet-2268	205	22	)	)	PUNCT
admet-2268	205	23	)	)	PUNCT
admet-2268	205	24	.	.	PUNCT
admet-2268	206	1	therefore	therefore	ADV
admet-2268	206	2	,	,	PUNCT
admet-2268	206	3	a	a	DET
admet-2268	206	4	higher	high	ADJ
admet-2268	206	5	level	level	NOUN
admet-2268	206	6	of	of	ADP
admet-2268	206	7	phospholipid	phospholipid	NOUN
admet-2268	206	8	and	and	CCONJ
admet-2268	206	9	edge	edge	NOUN
admet-2268	206	10	activator	activator	NOUN
admet-2268	206	11	(	(	PUNCT
admet-2268	206	12	sodium	sodium	NOUN
admet-2268	206	13	deoxycholate	deoxycholate	NOUN
admet-2268	206	14	)	)	PUNCT
admet-2268	206	15	is	be	AUX
admet-2268	206	16	suggested	suggest	VERB
admet-2268	206	17	for	for	ADP
admet-2268	206	18	producing	produce	VERB
admet-2268	206	19	transferosomes	transferosome	NOUN
admet-2268	206	20	of	of	ADP
admet-2268	206	21	smaller	small	ADJ
admet-2268	206	22	particle	particle	NOUN
admet-2268	206	23	size	size	NOUN
admet-2268	206	24	because	because	SCONJ
admet-2268	206	25	of	of	ADP
admet-2268	206	26	the	the	DET
admet-2268	206	27	higher	high	ADJ
admet-2268	206	28	flexibility	flexibility	NOUN
admet-2268	206	29	of	of	ADP
admet-2268	206	30	the	the	DET
admet-2268	206	31	lipid	lipid	NOUN
admet-2268	206	32	bilayer	bilayer	NOUN
admet-2268	206	33	.	.	PUNCT
admet-2268	207	1	the	the	DET
admet-2268	207	2	relationship	relationship	NOUN
admet-2268	207	3	between	between	ADP
admet-2268	207	4	the	the	DET
admet-2268	207	5	dependent	dependent	ADJ
admet-2268	207	6	and	and	CCONJ
admet-2268	207	7	independent	independent	ADJ
admet-2268	207	8	variables	variable	NOUN
admet-2268	207	9	was	be	AUX
admet-2268	207	10	further	far	ADV
admet-2268	207	11	elucidated	elucidated	ADJ
admet-2268	207	12	using	use	VERB
admet-2268	207	13	response	response	NOUN
admet-2268	207	14	surface	surface	NOUN
admet-2268	207	15	plots	plot	NOUN
admet-2268	207	16	.	.	PUNCT
admet-2268	208	1	figure	figure	NOUN
admet-2268	208	2	1	1	NUM
admet-2268	208	3	shows	show	VERB
admet-2268	208	4	that	that	SCONJ
admet-2268	208	5	the	the	DET
admet-2268	208	6	mean	mean	ADJ
admet-2268	208	7	vesicle	vesicle	NOUN
admet-2268	208	8	size	size	NOUN
admet-2268	208	9	decreases	decrease	VERB
admet-2268	208	10	with	with	ADP
admet-2268	208	11	an	an	DET
admet-2268	208	12	increase	increase	NOUN
admet-2268	208	13	in	in	ADP
admet-2268	208	14	phospholipid	phospholipid	NOUN
admet-2268	208	15	amount	amount	NOUN
admet-2268	208	16	.	.	PUNCT
admet-2268	209	1	sonication	sonication	NOUN
admet-2268	209	2	cycle	cycle	NOUN
admet-2268	209	3	time	time	NOUN
admet-2268	209	4	has	have	VERB
admet-2268	209	5	a	a	DET
admet-2268	209	6	suppressive	suppressive	ADJ
admet-2268	209	7	effect	effect	NOUN
admet-2268	209	8	on	on	ADP
admet-2268	209	9	the	the	DET
admet-2268	209	10	vesicle	vesicle	NOUN
admet-2268	209	11	size	size	NOUN
admet-2268	209	12	,	,	PUNCT
admet-2268	209	13	as	as	SCONJ
admet-2268	209	14	a	a	DET
admet-2268	209	15	higher	high	ADJ
admet-2268	209	16	level	level	NOUN
admet-2268	209	17	of	of	ADP
admet-2268	209	18	sonication	sonication	NOUN
admet-2268	209	19	cycle	cycle	NOUN
admet-2268	209	20	decreases	decrease	VERB
admet-2268	209	21	the	the	DET
admet-2268	209	22	aggregation	aggregation	NOUN
admet-2268	209	23	of	of	ADP
admet-2268	209	24	particles	particle	NOUN
admet-2268	209	25	and	and	CCONJ
admet-2268	209	26	reduces	reduce	VERB
admet-2268	209	27	the	the	DET
admet-2268	209	28	vesicle	vesicle	NOUN
admet-2268	209	29	size	size	NOUN
admet-2268	209	30	.	.	PUNCT
admet-2268	210	1	the	the	DET
admet-2268	210	2	encapsulation	encapsulation	NOUN
admet-2268	210	3	of	of	ADP
admet-2268	210	4	berberine	berberine	PROPN
admet-2268	210	5	hcl	hcl	PROPN
admet-2268	210	6	and	and	CCONJ
admet-2268	210	7	diacerein	diacerein	ADV
admet-2268	210	8	was	be	AUX
admet-2268	210	9	high	high	ADJ
admet-2268	210	10	(	(	PUNCT
admet-2268	210	11	59.24±1.5	59.24±1.5	NOUN
admet-2268	210	12	to	to	ADP
admet-2268	210	13	89.50±1.5	89.50±1.5	PROPN
admet-2268	210	14	%	%	NOUN
admet-2268	210	15	and	and	CCONJ
admet-2268	210	16	61.15±1.4	61.15±1.4	NUM
admet-2268	210	17	to	to	PART
admet-2268	210	18	91.23±1.8	91.23±1.8	NUM
admet-2268	210	19	%	%	NOUN
admet-2268	210	20	,	,	PUNCT
admet-2268	210	21	respectively	respectively	ADV
admet-2268	210	22	)	)	PUNCT
admet-2268	210	23	in	in	ADP
admet-2268	210	24	all	all	DET
admet-2268	210	25	the	the	DET
admet-2268	210	26	formulations	formulation	NOUN
admet-2268	210	27	with	with	ADP
admet-2268	210	28	good	good	ADJ
admet-2268	210	29	loading	loading	NOUN
admet-2268	210	30	efficiency	efficiency	NOUN
admet-2268	210	31	(	(	PUNCT
admet-2268	210	32	12.04±0.02	12.04±0.02	NUM
admet-2268	210	33	to	to	PART
admet-2268	210	34	19.41±0.47	19.41±0.47	NUM
admet-2268	210	35	%	%	NOUN
admet-2268	210	36	and	and	CCONJ
admet-2268	210	37	14.40±0.07	14.40±0.07	NUM
admet-2268	210	38	to	to	ADP
admet-2268	210	39	21.91±0.05	21.91±0.05	PROPN
admet-2268	210	40	%	%	NOUN
admet-2268	210	41	,	,	PUNCT
admet-2268	210	42	respectively	respectively	ADV
admet-2268	210	43	)	)	PUNCT
admet-2268	210	44	,	,	PUNCT
admet-2268	210	45	which	which	PRON
admet-2268	210	46	might	might	AUX
admet-2268	210	47	be	be	AUX
admet-2268	210	48	due	due	ADJ
admet-2268	210	49	to	to	ADP
admet-2268	210	50	the	the	DET
admet-2268	210	51	poor	poor	ADJ
admet-2268	210	52	aqueous	aqueous	ADJ
admet-2268	210	53	solubility	solubility	NOUN
admet-2268	210	54	of	of	ADP
admet-2268	210	55	the	the	DET
admet-2268	210	56	drugs	drug	NOUN
admet-2268	210	57	.	.	PUNCT
admet-2268	211	1	phosphatidylcholine	phosphatidylcholine	PROPN
admet-2268	211	2	had	have	VERB
admet-2268	211	3	a	a	DET
admet-2268	211	4	negative	negative	ADJ
admet-2268	211	5	correlation	correlation	NOUN
admet-2268	211	6	with	with	ADP
admet-2268	211	7	the	the	DET
admet-2268	211	8	encapsulation	encapsulation	NOUN
admet-2268	211	9	of	of	ADP
admet-2268	211	10	berberine	berberine	PROPN
admet-2268	211	11	hcl	hcl	PROPN
admet-2268	211	12	and	and	CCONJ
admet-2268	211	13	diacerein	diacerein	ADJ
admet-2268	211	14	(	(	PUNCT
admet-2268	211	15	equations	equation	NOUN
admet-2268	211	16	(	(	PUNCT
admet-2268	211	17	7	7	NUM
admet-2268	211	18	)	)	PUNCT
admet-2268	211	19	and	and	CCONJ
admet-2268	211	20	(	(	PUNCT
admet-2268	211	21	8)	8)	NUM
admet-2268	211	22	)	)	PUNCT
admet-2268	211	23	.	.	PUNCT
admet-2268	212	1	this	this	PRON
admet-2268	212	2	means	mean	VERB
admet-2268	212	3	that	that	SCONJ
admet-2268	212	4	higher	high	ADJ
admet-2268	212	5	levels	level	NOUN
admet-2268	212	6	of	of	ADP
admet-2268	212	7	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	212	8	decrease	decrease	NOUN
admet-2268	212	9	the	the	DET
admet-2268	212	10	drug	drug	NOUN
admet-2268	212	11	encapsulation	encapsulation	NOUN
admet-2268	212	12	in	in	ADP
admet-2268	212	13	the	the	DET
admet-2268	212	14	transferosomes	transferosome	NOUN
admet-2268	212	15	[	[	X
admet-2268	212	16	31	31	NUM
admet-2268	212	17	]	]	PUNCT
admet-2268	212	18	.	.	PUNCT
admet-2268	213	1	so	so	ADV
admet-2268	213	2	,	,	PUNCT
admet-2268	213	3	a	a	DET
admet-2268	213	4	lower	low	ADJ
admet-2268	213	5	level	level	NOUN
admet-2268	213	6	of	of	ADP
admet-2268	213	7	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	213	8	is	be	AUX
admet-2268	213	9	suggested	suggest	VERB
admet-2268	213	10	for	for	ADP
admet-2268	213	11	high	high	ADJ
admet-2268	213	12	drug	drug	NOUN
admet-2268	213	13	encapsulation	encapsulation	NOUN
admet-2268	213	14	.	.	PUNCT
admet-2268	214	1	on	on	ADP
admet-2268	214	2	the	the	DET
admet-2268	214	3	other	other	ADJ
admet-2268	214	4	hand	hand	NOUN
admet-2268	214	5	,	,	PUNCT
admet-2268	214	6	sodium	sodium	NOUN
admet-2268	214	7	deoxycholate	deoxycholate	NOUN
admet-2268	214	8	had	have	VERB
admet-2268	214	9	a	a	DET
admet-2268	214	10	positive	positive	ADJ
admet-2268	214	11	correlation	correlation	NOUN
admet-2268	214	12	with	with	ADP
admet-2268	214	13	berberine	berberine	NOUN
admet-2268	214	14	hcl	hcl	PROPN
admet-2268	214	15	encapsulation	encapsulation	PROPN
admet-2268	214	16	(	(	PUNCT
admet-2268	214	17	equation	equation	NOUN
admet-2268	214	18	(	(	PUNCT
admet-2268	214	19	7	7	NUM
admet-2268	214	20	)	)	PUNCT
admet-2268	214	21	,	,	PUNCT
admet-2268	214	22	figure	figure	NOUN
admet-2268	214	23	2	2	NUM
admet-2268	214	24	)	)	PUNCT
admet-2268	214	25	,	,	PUNCT
admet-2268	214	26	and	and	CCONJ
admet-2268	214	27	a	a	DET
admet-2268	214	28	negative	negative	ADJ
admet-2268	214	29	correlation	correlation	NOUN
admet-2268	214	30	with	with	ADP
admet-2268	214	31	diacerein	diacerein	ADJ
admet-2268	214	32	encapsulation	encapsulation	NOUN
admet-2268	214	33	(	(	PUNCT
admet-2268	214	34	equation	equation	NOUN
admet-2268	214	35	(	(	PUNCT
admet-2268	214	36	8)	8)	NUM
admet-2268	214	37	,	,	PUNCT
admet-2268	214	38	figure	figure	NOUN
admet-2268	214	39	3	3	NUM
admet-2268	214	40	)	)	PUNCT
admet-2268	214	41	.	.	PUNCT
admet-2268	215	1	however	however	ADV
admet-2268	215	2	,	,	PUNCT
admet-2268	215	3	a	a	DET
admet-2268	215	4	negative	negative	ADJ
admet-2268	215	5	effect	effect	NOUN
admet-2268	215	6	of	of	ADP
admet-2268	215	7	edge	edge	NOUN
admet-2268	215	8	activator	activator	NOUN
admet-2268	215	9	concentration	concentration	NOUN
admet-2268	215	10	on	on	ADP
admet-2268	215	11	drug	drug	NOUN
admet-2268	215	12	entrapment	entrapment	NOUN
admet-2268	215	13	efficiency	efficiency	NOUN
admet-2268	215	14	has	have	AUX
admet-2268	215	15	been	be	AUX
admet-2268	215	16	reported	report	VERB
admet-2268	215	17	earlier	early	ADV
admet-2268	215	18	[	[	X
admet-2268	215	19	32	32	NUM
admet-2268	215	20	]	]	PUNCT
admet-2268	215	21	.	.	PUNCT
admet-2268	216	1	the	the	DET
admet-2268	216	2	presence	presence	NOUN
admet-2268	216	3	of	of	ADP
admet-2268	216	4	a	a	DET
admet-2268	216	5	higher	high	ADJ
admet-2268	216	6	surfactant	surfactant	ADJ
admet-2268	216	7	content	content	NOUN
admet-2268	216	8	may	may	AUX
admet-2268	216	9	lead	lead	VERB
admet-2268	216	10	to	to	ADP
admet-2268	216	11	a	a	DET
admet-2268	216	12	decrease	decrease	NOUN
admet-2268	216	13	in	in	ADP
admet-2268	216	14	entrapment	entrapment	ADJ
admet-2268	216	15	efficiency	efficiency	NOUN
admet-2268	216	16	[	[	X
admet-2268	216	17	33,34	33,34	NOUN
admet-2268	216	18	]	]	PUNCT
admet-2268	216	19	.	.	PUNCT
admet-2268	217	1	this	this	PRON
admet-2268	217	2	could	could	AUX
admet-2268	217	3	be	be	AUX
admet-2268	217	4	attributed	attribute	VERB
admet-2268	217	5	to	to	ADP
admet-2268	217	6	the	the	DET
admet-2268	217	7	elevated	elevated	ADJ
admet-2268	217	8	permeability	permeability	NOUN
admet-2268	217	9	of	of	ADP
admet-2268	217	10	the	the	DET
admet-2268	217	11	vesicle	vesicle	NOUN
admet-2268	217	12	membrane	membrane	NOUN
admet-2268	217	13	caused	cause	VERB
admet-2268	217	14	by	by	ADP
admet-2268	217	15	the	the	DET
admet-2268	217	16	organization	organization	NOUN
admet-2268	217	17	of	of	ADP
admet-2268	217	18	surfactant	surfactant	ADJ
admet-2268	217	19	molecules	molecule	NOUN
admet-2268	217	20	within	within	ADP
admet-2268	217	21	the	the	DET
admet-2268	217	22	lipid	lipid	ADJ
admet-2268	217	23	bilayer	bilayer	NOUN
admet-2268	217	24	structure	structure	NOUN
admet-2268	217	25	of	of	ADP
admet-2268	217	26	the	the	DET
admet-2268	217	27	vesicle	vesicle	NOUN
admet-2268	217	28	.	.	PUNCT
admet-2268	218	1	this	this	DET
admet-2268	218	2	arrangement	arrangement	NOUN
admet-2268	218	3	may	may	AUX
admet-2268	218	4	create	create	VERB
admet-2268	218	5	openings	opening	NOUN
admet-2268	218	6	in	in	ADP
admet-2268	218	7	the	the	DET
admet-2268	218	8	vesicle	vesicle	NOUN
admet-2268	218	9	membrane	membrane	NOUN
admet-2268	218	10	,	,	PUNCT
admet-2268	218	11	resulting	result	VERB
admet-2268	218	12	in	in	ADP
admet-2268	218	13	enhanced	enhanced	ADJ
admet-2268	218	14	fluidity	fluidity	NOUN
admet-2268	218	15	and	and	CCONJ
admet-2268	218	16	causing	cause	VERB
admet-2268	218	17	the	the	DET
admet-2268	218	18	drug	drug	NOUN
admet-2268	218	19	contained	contain	VERB
admet-2268	218	20	within	within	ADP
admet-2268	218	21	to	to	PART
admet-2268	218	22	leak	leak	VERB
admet-2268	218	23	out	out	ADP
admet-2268	218	24	[	[	X
admet-2268	218	25	10,35	10,35	ADJ
admet-2268	218	26	]	]	X
admet-2268	218	27	.	.	PUNCT
admet-2268	219	1	a	a	DET
admet-2268	219	2	higher	high	ADJ
admet-2268	219	3	level	level	NOUN
admet-2268	219	4	of	of	ADP
admet-2268	219	5	surfactant	surfactant	NOUN
admet-2268	219	6	can	can	AUX
admet-2268	219	7	increase	increase	VERB
admet-2268	219	8	the	the	DET
admet-2268	219	9	number	number	NOUN
admet-2268	219	10	of	of	ADP
admet-2268	219	11	vesicles	vesicle	NOUN
admet-2268	219	12	produced	produce	VERB
admet-2268	219	13	,	,	PUNCT
admet-2268	219	14	resulting	result	VERB
admet-2268	219	15	in	in	ADP
admet-2268	219	16	a	a	DET
admet-2268	219	17	greater	great	ADJ
admet-2268	219	18	volume	volume	NOUN
admet-2268	219	19	of	of	ADP
admet-2268	219	20	the	the	DET
admet-2268	219	21	hydrophobic	hydrophobic	NOUN
admet-2268	219	22	bilayer	bilayer	NOUN
admet-2268	219	23	region	region	NOUN
admet-2268	219	24	that	that	PRON
admet-2268	219	25	can	can	AUX
admet-2268	219	26	accommodate	accommodate	VERB
admet-2268	219	27	hydrophobic	hydrophobic	NOUN
admet-2268	219	28	drugs	drug	NOUN
admet-2268	219	29	[	[	X
admet-2268	219	30	10	10	NUM
admet-2268	219	31	]	]	PUNCT
admet-2268	219	32	.	.	PUNCT
admet-2268	220	1	this	this	PRON
admet-2268	220	2	could	could	AUX
admet-2268	220	3	be	be	AUX
admet-2268	220	4	a	a	DET
admet-2268	220	5	possible	possible	ADJ
admet-2268	220	6	reason	reason	NOUN
admet-2268	220	7	for	for	ADP
admet-2268	220	8	the	the	DET
admet-2268	220	9	high	high	ADJ
admet-2268	220	10	entrapment	entrapment	NOUN
admet-2268	220	11	of	of	ADP
admet-2268	220	12	diacerein	diacerein	ADJ
admet-2268	220	13	.	.	PUNCT
admet-2268	221	1	table	table	NOUN
admet-2268	221	2	3	3	NUM
admet-2268	221	3	shows	show	VERB
admet-2268	221	4	that	that	SCONJ
admet-2268	221	5	there	there	PRON
admet-2268	221	6	was	be	VERB
admet-2268	221	7	a	a	DET
admet-2268	221	8	good	good	ADJ
admet-2268	221	9	degree	degree	NOUN
admet-2268	221	10	of	of	ADP
admet-2268	221	11	agreement	agreement	NOUN
admet-2268	221	12	between	between	ADP
admet-2268	221	13	the	the	DET
admet-2268	221	14	observed	observe	VERB
admet-2268	221	15	and	and	CCONJ
admet-2268	221	16	predicted	predict	VERB
admet-2268	221	17	values	value	NOUN
admet-2268	221	18	,	,	PUNCT
admet-2268	221	19	indicating	indicate	VERB
admet-2268	221	20	the	the	DET
admet-2268	221	21	validity	validity	NOUN
admet-2268	221	22	of	of	ADP
admet-2268	221	23	the	the	DET
admet-2268	221	24	established	establish	VERB
admet-2268	221	25	model	model	NOUN
admet-2268	221	26	.	.	PUNCT
admet-2268	222	1	the	the	DET
admet-2268	222	2	probable	probable	ADJ
admet-2268	222	3	interactions	interaction	NOUN
admet-2268	222	4	between	between	ADP
admet-2268	222	5	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	222	6	(	(	PUNCT
admet-2268	222	7	phospholipid	phospholipid	NOUN
admet-2268	222	8	)	)	PUNCT
admet-2268	222	9	,	,	PUNCT
admet-2268	222	10	sodium	sodium	NOUN
admet-2268	222	11	deoxycholate	deoxycholate	ADJ
admet-2268	222	12	(	(	PUNCT
admet-2268	222	13	edge	edge	NOUN
admet-2268	222	14	activator	activator	NOUN
admet-2268	222	15	)	)	PUNCT
admet-2268	222	16	,	,	PUNCT
admet-2268	222	17	and	and	CCONJ
admet-2268	222	18	affecting	affect	VERB
admet-2268	222	19	particle	particle	NOUN
admet-2268	222	20	size	size	NOUN
admet-2268	222	21	(	(	PUNCT
admet-2268	222	22	a	a	NOUN
admet-2268	222	23	)	)	PUNCT
admet-2268	222	24	,	,	PUNCT
admet-2268	222	25	and	and	CCONJ
admet-2268	222	26	entrapment	entrapment	ADJ
admet-2268	222	27	efficiency	efficiency	NOUN
admet-2268	222	28	of	of	ADP
admet-2268	222	29	berberine	berberine	NOUN
admet-2268	222	30	hcl	hcl	PROPN
admet-2268	222	31	(	(	PUNCT
admet-2268	222	32	b	b	NOUN
admet-2268	222	33	)	)	PUNCT
admet-2268	222	34	and	and	CCONJ
admet-2268	222	35	diacerein	diacerein	ADJ
admet-2268	222	36	(	(	PUNCT
admet-2268	222	37	c	c	X
admet-2268	222	38	)	)	PUNCT
admet-2268	222	39	were	be	AUX
admet-2268	222	40	systematically	systematically	ADV
admet-2268	222	41	investigated	investigate	VERB
admet-2268	222	42	(	(	PUNCT
admet-2268	222	43	figure	figure	NOUN
admet-2268	222	44	4	4	NUM
admet-2268	222	45	)	)	PUNCT
admet-2268	222	46	.	.	PUNCT
admet-2268	223	1	this	this	DET
admet-2268	223	2	study	study	NOUN
admet-2268	223	3	showed	show	VERB
admet-2268	223	4	a	a	DET
admet-2268	223	5	higher	high	ADJ
admet-2268	223	6	drug	drug	NOUN
admet-2268	223	7	encapsulation	encapsulation	NOUN
admet-2268	223	8	and	and	CCONJ
admet-2268	223	9	loading	loading	NOUN
admet-2268	223	10	,	,	PUNCT
admet-2268	223	11	surpassing	surpass	VERB
admet-2268	223	12	the	the	DET
admet-2268	223	13	findings	finding	NOUN
admet-2268	223	14	of	of	ADP
admet-2268	223	15	a	a	DET
admet-2268	223	16	previously	previously	ADV
admet-2268	223	17	reported	report	VERB
admet-2268	223	18	study	study	NOUN
admet-2268	223	19	[	[	X
admet-2268	223	20	20	20	NUM
admet-2268	223	21	]	]	PUNCT
admet-2268	223	22	.	.	PUNCT
admet-2268	224	1	admet	admet	PROPN
admet-2268	224	2	&	&	CCONJ
admet-2268	224	3	dmpk	dmpk	PROPN
admet-2268	224	4	12(3	12(3	PROPN
admet-2268	224	5	)	)	PUNCT
admet-2268	224	6	(	(	PUNCT
admet-2268	224	7	2024	2024	NUM
admet-2268	224	8	)	)	PUNCT
admet-2268	224	9	553	553	NUM
admet-2268	224	10	-	-	SYM
admet-2268	224	11	580	580	NUM
admet-2268	224	12	berberine	berberine	NOUN
admet-2268	224	13	hcl	hcl	PROPN
admet-2268	224	14	and	and	CCONJ
admet-2268	224	15	diacerein	diacerein	ADV
admet-2268	224	16	loaded	load	VERB
admet-2268	224	17	dual	dual	ADJ
admet-2268	224	18	delivery	delivery	NOUN
admet-2268	224	19	transferosomes	transferosome	NOUN
admet-2268	224	20	doi	doi	PROPN
admet-2268	224	21	:	:	PUNCT
admet-2268	224	22	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	224	23	561	561	NUM
admet-2268	224	24	figure	figure	NOUN
admet-2268	224	25	1	1	NUM
admet-2268	224	26	.	.	PUNCT
admet-2268	225	1	contour	contour	NOUN
admet-2268	225	2	plots	plot	NOUN
admet-2268	225	3	and	and	CCONJ
admet-2268	225	4	3d	3d	NUM
admet-2268	225	5	response	response	NOUN
admet-2268	225	6	surface	surface	NOUN
admet-2268	225	7	of	of	ADP
admet-2268	225	8	parameters	parameter	NOUN
admet-2268	225	9	as	as	ADP
admet-2268	225	10	a	a	DET
admet-2268	225	11	function	function	NOUN
admet-2268	225	12	of	of	ADP
admet-2268	225	13	formulation	formulation	NOUN
admet-2268	225	14	variables	variable	NOUN
admet-2268	225	15	(	(	PUNCT
admet-2268	225	16	particle	particle	NOUN
admet-2268	225	17	size	size	NOUN
admet-2268	225	18	):	):	PUNCT
admet-2268	225	19	amount	amount	NOUN
admet-2268	225	20	of	of	ADP
admet-2268	225	21	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	225	22	and	and	CCONJ
admet-2268	225	23	amount	amount	NOUN
admet-2268	225	24	of	of	ADP
admet-2268	225	25	sodium	sodium	NOUN
admet-2268	225	26	deoxycholate	deoxycholate	ADJ
admet-2268	225	27	(	(	PUNCT
admet-2268	225	28	i	i	NOUN
admet-2268	225	29	)	)	PUNCT
admet-2268	225	30	,	,	PUNCT
admet-2268	225	31	sonication	sonication	NOUN
admet-2268	225	32	cycles	cycle	NOUN
admet-2268	225	33	and	and	CCONJ
admet-2268	225	34	amount	amount	NOUN
admet-2268	225	35	of	of	ADP
admet-2268	225	36	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	225	37	(	(	PUNCT
admet-2268	225	38	ii	ii	NOUN
admet-2268	225	39	)	)	PUNCT
admet-2268	225	40	,	,	PUNCT
admet-2268	225	41	and	and	CCONJ
admet-2268	225	42	sonication	sonication	NOUN
admet-2268	225	43	time	time	NOUN
admet-2268	225	44	and	and	CCONJ
admet-2268	225	45	amount	amount	NOUN
admet-2268	225	46	of	of	ADP
admet-2268	225	47	sodium	sodium	NOUN
admet-2268	225	48	deoxycholate	deoxycholate	ADJ
admet-2268	225	49	(	(	PUNCT
admet-2268	225	50	ii	ii	NOUN
admet-2268	225	51	)	)	PUNCT
admet-2268	225	52	.	.	PUNCT
admet-2268	226	1	the	the	DET
admet-2268	226	2	amount	amount	NOUN
admet-2268	226	3	of	of	ADP
admet-2268	226	4	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	226	5	(	(	PUNCT
admet-2268	226	6	a	a	X
admet-2268	226	7	)	)	PUNCT
admet-2268	226	8	had	have	VERB
admet-2268	226	9	a	a	DET
admet-2268	226	10	relatively	relatively	ADV
admet-2268	226	11	greater	great	ADJ
admet-2268	226	12	influence	influence	NOUN
admet-2268	226	13	(	(	PUNCT
admet-2268	226	14	p	p	X
admet-2268	226	15	<	<	X
admet-2268	226	16	0.05	0.05	NUM
admet-2268	226	17	)	)	PUNCT
admet-2268	226	18	on	on	ADP
admet-2268	226	19	vesicle	vesicle	NOUN
admet-2268	226	20	size	size	NOUN
admet-2268	226	21	(	(	PUNCT
admet-2268	226	22	y1	y1	NOUN
admet-2268	226	23	)	)	PUNCT
admet-2268	226	24	(	(	PUNCT
admet-2268	226	25	f	f	PROPN
admet-2268	226	26	value	value	NOUN
admet-2268	226	27	151.47	151.47	NUM
admet-2268	226	28	)	)	PUNCT
admet-2268	226	29	than	than	ADP
admet-2268	226	30	the	the	DET
admet-2268	226	31	amount	amount	NOUN
admet-2268	226	32	of	of	ADP
admet-2268	226	33	sodium	sodium	NOUN
admet-2268	226	34	deoxycholate	deoxycholate	VERB
admet-2268	226	35	(	(	PUNCT
admet-2268	226	36	b	b	NOUN
admet-2268	226	37	)	)	PUNCT
admet-2268	226	38	(	(	PUNCT
admet-2268	226	39	f	f	PROPN
admet-2268	226	40	value	value	NOUN
admet-2268	226	41	41.57	41.57	NUM
admet-2268	226	42	)	)	PUNCT
admet-2268	226	43	and	and	CCONJ
admet-2268	226	44	sonication	sonication	NOUN
admet-2268	226	45	cycle	cycle	NOUN
admet-2268	226	46	time	time	NOUN
admet-2268	226	47	(	(	PUNCT
admet-2268	226	48	c	c	NOUN
admet-2268	226	49	)	)	PUNCT
admet-2268	226	50	(	(	PUNCT
admet-2268	226	51	f	f	PROPN
admet-2268	226	52	value	value	NOUN
admet-2268	226	53	12.37	12.37	NUM
admet-2268	226	54	)	)	PUNCT
admet-2268	226	55	.	.	PUNCT
admet-2268	227	1	sonication	sonication	NOUN
admet-2268	227	2	cycle	cycle	NOUN
admet-2268	227	3	time	time	NOUN
admet-2268	227	4	showed	show	VERB
admet-2268	227	5	a	a	DET
admet-2268	227	6	suppressive	suppressive	ADJ
admet-2268	227	7	effect	effect	NOUN
admet-2268	227	8	on	on	ADP
admet-2268	227	9	vesicle	vesicle	NOUN
admet-2268	227	10	size	size	NOUN
admet-2268	227	11	.	.	PUNCT
admet-2268	228	1	the	the	DET
admet-2268	228	2	combination	combination	NOUN
admet-2268	228	3	of	of	ADP
admet-2268	228	4	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	228	5	s.	s.	PROPN
admet-2268	228	6	singh	singh	PROPN
admet-2268	228	7	and	and	CCONJ
admet-2268	228	8	r.	r.	PROPN
admet-2268	228	9	awasthi	awasthi	PROPN
admet-2268	228	10	admet	admet	PROPN
admet-2268	228	11	&	&	CCONJ
admet-2268	228	12	dmpk	dmpk	PROPN
admet-2268	228	13	12(3	12(3	PROPN
admet-2268	228	14	)	)	PUNCT
admet-2268	228	15	(	(	PUNCT
admet-2268	228	16	2024	2024	NUM
admet-2268	228	17	)	)	PUNCT
admet-2268	228	18	553	553	NUM
admet-2268	228	19	-	-	SYM
admet-2268	228	20	580	580	NUM
admet-2268	228	21	562	562	NUM
admet-2268	228	22	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	228	23	and	and	CCONJ
admet-2268	228	24	sodium	sodium	NOUN
admet-2268	228	25	deoxycholate	deoxycholate	ADJ
admet-2268	228	26	(	(	PUNCT
admet-2268	228	27	ab	ab	NOUN
admet-2268	228	28	)	)	PUNCT
admet-2268	228	29	significantly	significantly	ADV
admet-2268	228	30	influenced	influence	VERB
admet-2268	228	31	the	the	DET
admet-2268	228	32	vesicle	vesicle	NOUN
admet-2268	228	33	size	size	NOUN
admet-2268	228	34	(	(	PUNCT
admet-2268	228	35	f	f	PROPN
admet-2268	228	36	value	value	NOUN
admet-2268	228	37	5.68	5.68	NUM
admet-2268	228	38	and	and	CCONJ
admet-2268	228	39	p	p	NOUN
admet-2268	228	40	value	value	NOUN
admet-2268	228	41	0.0974	0.0974	NUM
admet-2268	228	42	)	)	PUNCT
admet-2268	228	43	.	.	PUNCT
admet-2268	229	1	in	in	ADP
admet-2268	229	2	comparison	comparison	NOUN
admet-2268	229	3	to	to	ADP
admet-2268	229	4	the	the	DET
admet-2268	229	5	effect	effect	NOUN
admet-2268	229	6	of	of	ADP
admet-2268	229	7	the	the	DET
admet-2268	229	8	combination	combination	NOUN
admet-2268	229	9	of	of	ADP
admet-2268	229	10	variables	variable	NOUN
admet-2268	229	11	,	,	PUNCT
admet-2268	229	12	the	the	DET
admet-2268	229	13	influence	influence	NOUN
admet-2268	229	14	squared	square	VERB
admet-2268	229	15	form	form	NOUN
admet-2268	229	16	of	of	ADP
admet-2268	229	17	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	229	18	amount	amount	NOUN
admet-2268	229	19	(	(	PUNCT
admet-2268	229	20	a2	a2	NOUN
admet-2268	229	21	)	)	PUNCT
admet-2268	229	22	had	have	VERB
admet-2268	229	23	a	a	DET
admet-2268	229	24	higher	high	ADJ
admet-2268	229	25	effect	effect	NOUN
admet-2268	229	26	on	on	ADP
admet-2268	229	27	vesicle	vesicle	NOUN
admet-2268	229	28	size	size	NOUN
admet-2268	229	29	(	(	PUNCT
admet-2268	229	30	f	f	PROPN
admet-2268	229	31	value	value	NOUN
admet-2268	229	32	16.30	16.30	NUM
admet-2268	229	33	)	)	PUNCT
admet-2268	229	34	(	(	PUNCT
admet-2268	229	35	table	table	NOUN
admet-2268	229	36	4	4	NUM
admet-2268	229	37	)	)	PUNCT
admet-2268	229	38	.	.	PUNCT
admet-2268	230	1	figure	figure	NOUN
admet-2268	230	2	2	2	NUM
admet-2268	230	3	.	.	PUNCT
admet-2268	231	1	contour	contour	NOUN
admet-2268	231	2	plots	plot	NOUN
admet-2268	231	3	and	and	CCONJ
admet-2268	231	4	3d	3d	NUM
admet-2268	231	5	response	response	NOUN
admet-2268	231	6	surface	surface	NOUN
admet-2268	231	7	of	of	ADP
admet-2268	231	8	parameters	parameter	NOUN
admet-2268	231	9	as	as	ADP
admet-2268	231	10	a	a	DET
admet-2268	231	11	function	function	NOUN
admet-2268	231	12	of	of	ADP
admet-2268	231	13	formulation	formulation	NOUN
admet-2268	231	14	variables	variable	NOUN
admet-2268	231	15	(	(	PUNCT
admet-2268	231	16	entrapment	entrapment	ADJ
admet-2268	231	17	efficiency	efficiency	NOUN
admet-2268	231	18	of	of	ADP
admet-2268	231	19	berberine	berberine	NOUN
admet-2268	231	20	hcl	hcl	PROPN
admet-2268	231	21	):	):	PUNCT
admet-2268	231	22	amount	amount	NOUN
admet-2268	231	23	of	of	ADP
admet-2268	231	24	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	231	25	and	and	CCONJ
admet-2268	231	26	amount	amount	NOUN
admet-2268	231	27	of	of	ADP
admet-2268	231	28	sodium	sodium	NOUN
admet-2268	231	29	deoxycholate	deoxycholate	ADJ
admet-2268	231	30	(	(	PUNCT
admet-2268	231	31	i	i	NOUN
admet-2268	231	32	)	)	PUNCT
admet-2268	231	33	,	,	PUNCT
admet-2268	231	34	sonication	sonication	NOUN
admet-2268	231	35	time	time	NOUN
admet-2268	231	36	and	and	CCONJ
admet-2268	231	37	amount	amount	NOUN
admet-2268	231	38	of	of	ADP
admet-2268	231	39	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	231	40	(	(	PUNCT
admet-2268	231	41	ii	ii	NOUN
admet-2268	231	42	)	)	PUNCT
admet-2268	231	43	,	,	PUNCT
admet-2268	231	44	and	and	CCONJ
admet-2268	231	45	sonication	sonication	NOUN
admet-2268	231	46	cycles	cycle	NOUN
admet-2268	231	47	and	and	CCONJ
admet-2268	231	48	amount	amount	NOUN
admet-2268	231	49	of	of	ADP
admet-2268	231	50	sodium	sodium	NOUN
admet-2268	231	51	deoxycholate	deoxycholate	ADJ
admet-2268	231	52	(	(	PUNCT
admet-2268	231	53	iii	iii	NOUN
admet-2268	231	54	)	)	PUNCT
admet-2268	231	55	.	.	PUNCT
admet-2268	232	1	admet	admet	PROPN
admet-2268	232	2	&	&	CCONJ
admet-2268	232	3	dmpk	dmpk	PROPN
admet-2268	232	4	12(3	12(3	PROPN
admet-2268	232	5	)	)	PUNCT
admet-2268	232	6	(	(	PUNCT
admet-2268	232	7	2024	2024	NUM
admet-2268	232	8	)	)	PUNCT
admet-2268	232	9	553	553	NUM
admet-2268	232	10	-	-	SYM
admet-2268	232	11	580	580	NUM
admet-2268	232	12	berberine	berberine	NOUN
admet-2268	232	13	hcl	hcl	PROPN
admet-2268	232	14	and	and	CCONJ
admet-2268	232	15	diacerein	diacerein	ADV
admet-2268	232	16	loaded	load	VERB
admet-2268	232	17	dual	dual	ADJ
admet-2268	232	18	delivery	delivery	NOUN
admet-2268	232	19	transferosomes	transferosome	NOUN
admet-2268	232	20	doi	doi	PROPN
admet-2268	232	21	:	:	PUNCT
admet-2268	232	22	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	232	23	563	563	NUM
admet-2268	232	24	figure	figure	NOUN
admet-2268	232	25	3	3	NUM
admet-2268	232	26	.	.	PUNCT
admet-2268	232	27	contour	contour	NOUN
admet-2268	232	28	plots	plot	NOUN
admet-2268	232	29	and	and	CCONJ
admet-2268	232	30	3d	3d	NUM
admet-2268	232	31	response	response	NOUN
admet-2268	232	32	surface	surface	NOUN
admet-2268	232	33	of	of	ADP
admet-2268	232	34	parameters	parameter	NOUN
admet-2268	232	35	as	as	ADP
admet-2268	232	36	a	a	DET
admet-2268	232	37	function	function	NOUN
admet-2268	232	38	of	of	ADP
admet-2268	232	39	formulation	formulation	NOUN
admet-2268	232	40	variables	variable	NOUN
admet-2268	232	41	(	(	PUNCT
admet-2268	232	42	entrapment	entrapment	ADJ
admet-2268	232	43	efficiency	efficiency	NOUN
admet-2268	232	44	of	of	ADP
admet-2268	232	45	diacerein	diacerein	ADJ
admet-2268	232	46	):	):	PUNCT
admet-2268	232	47	amount	amount	NOUN
admet-2268	232	48	of	of	ADP
admet-2268	232	49	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	232	50	and	and	CCONJ
admet-2268	232	51	amount	amount	NOUN
admet-2268	232	52	of	of	ADP
admet-2268	232	53	sodium	sodium	NOUN
admet-2268	232	54	deoxycholate	deoxycholate	ADJ
admet-2268	232	55	(	(	PUNCT
admet-2268	232	56	i	i	NOUN
admet-2268	232	57	)	)	PUNCT
admet-2268	232	58	,	,	PUNCT
admet-2268	232	59	sonication	sonication	NOUN
admet-2268	232	60	time	time	NOUN
admet-2268	232	61	and	and	CCONJ
admet-2268	232	62	amount	amount	NOUN
admet-2268	232	63	of	of	ADP
admet-2268	232	64	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	232	65	(	(	PUNCT
admet-2268	232	66	ii	ii	NOUN
admet-2268	232	67	)	)	PUNCT
admet-2268	232	68	,	,	PUNCT
admet-2268	232	69	and	and	CCONJ
admet-2268	232	70	sonication	sonication	NOUN
admet-2268	232	71	time	time	NOUN
admet-2268	232	72	and	and	CCONJ
admet-2268	232	73	amount	amount	NOUN
admet-2268	232	74	of	of	ADP
admet-2268	232	75	sodium	sodium	NOUN
admet-2268	232	76	deoxycholate	deoxycholate	ADJ
admet-2268	232	77	(	(	PUNCT
admet-2268	232	78	iii	iii	NOUN
admet-2268	232	79	)	)	PUNCT
admet-2268	232	80	.	.	PUNCT
admet-2268	233	1	the	the	DET
admet-2268	233	2	amount	amount	NOUN
admet-2268	233	3	of	of	ADP
admet-2268	233	4	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	233	5	,	,	PUNCT
admet-2268	233	6	amount	amount	NOUN
admet-2268	233	7	of	of	ADP
admet-2268	233	8	sodium	sodium	NOUN
admet-2268	233	9	deoxycholate	deoxycholate	ADJ
admet-2268	233	10	and	and	CCONJ
admet-2268	233	11	sonication	sonication	NOUN
admet-2268	233	12	cycle	cycle	NOUN
admet-2268	233	13	time	time	NOUN
admet-2268	233	14	exhibit	exhibit	VERB
admet-2268	233	15	significant	significant	ADJ
admet-2268	233	16	effects	effect	NOUN
admet-2268	233	17	on	on	ADP
admet-2268	233	18	entrapment	entrapment	ADJ
admet-2268	233	19	efficiency	efficiency	NOUN
admet-2268	233	20	(	(	PUNCT
admet-2268	233	21	y2	y2	NOUN
admet-2268	233	22	and	and	CCONJ
admet-2268	233	23	y3	y3	NOUN
admet-2268	233	24	)	)	PUNCT
admet-2268	233	25	at	at	ADP
admet-2268	233	26	p	p	NOUN
admet-2268	233	27	<	<	X
admet-2268	233	28	0.05	0.05	NUM
admet-2268	233	29	.	.	PUNCT
admet-2268	234	1	the	the	DET
admet-2268	234	2	amount	amount	NOUN
admet-2268	234	3	of	of	ADP
admet-2268	234	4	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	234	5	(	(	PUNCT
admet-2268	234	6	a	a	X
admet-2268	234	7	)	)	PUNCT
admet-2268	234	8	had	have	VERB
admet-2268	234	9	a	a	DET
admet-2268	234	10	relatively	relatively	ADV
admet-2268	234	11	greater	great	ADJ
admet-2268	234	12	influence	influence	NOUN
admet-2268	234	13	on	on	ADP
admet-2268	234	14	entrapment	entrapment	ADJ
admet-2268	234	15	efficiency	efficiency	NOUN
admet-2268	234	16	(	(	PUNCT
admet-2268	234	17	y2	y2	NOUN
admet-2268	234	18	and	and	CCONJ
admet-2268	234	19	y3	y3	NOUN
admet-2268	234	20	)	)	PUNCT
admet-2268	234	21	than	than	ADP
admet-2268	234	22	the	the	DET
admet-2268	234	23	amount	amount	NOUN
admet-2268	234	24	of	of	ADP
admet-2268	234	25	sodium	sodium	NOUN
admet-2268	234	26	deoxycholate	deoxycholate	VERB
admet-2268	234	27	(	(	PUNCT
admet-2268	234	28	b	b	NOUN
admet-2268	234	29	)	)	PUNCT
admet-2268	234	30	and	and	CCONJ
admet-2268	234	31	sonication	sonication	NOUN
admet-2268	234	32	cycle	cycle	NOUN
admet-2268	234	33	time	time	NOUN
admet-2268	234	34	(	(	PUNCT
admet-2268	234	35	c	c	NOUN
admet-2268	234	36	)	)	PUNCT
admet-2268	234	37	as	as	SCONJ
admet-2268	234	38	indicated	indicate	VERB
admet-2268	234	39	by	by	ADP
admet-2268	234	40	measured	measure	VERB
admet-2268	234	41	f	f	PROPN
admet-2268	234	42	values	value	NOUN
admet-2268	234	43	(	(	PUNCT
admet-2268	234	44	21.93	21.93	NUM
admet-2268	234	45	and	and	CCONJ
admet-2268	234	46	28.90	28.90	NUM
admet-2268	234	47	,	,	PUNCT
admet-2268	234	48	respectively	respectively	ADV
admet-2268	234	49	for	for	ADP
admet-2268	234	50	berberine	berberine	NOUN
admet-2268	234	51	hcl	hcl	PROPN
admet-2268	234	52	and	and	CCONJ
admet-2268	234	53	diacerein	diacerein	ADJ
admet-2268	234	54	)	)	PUNCT
admet-2268	234	55	.	.	PUNCT
admet-2268	235	1	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	PROPN
admet-2268	235	2	s.	s.	PROPN
admet-2268	235	3	singh	singh	PROPN
admet-2268	235	4	and	and	CCONJ
admet-2268	235	5	r.	r.	PROPN
admet-2268	235	6	awasthi	awasthi	PROPN
admet-2268	235	7	admet	admet	PROPN
admet-2268	235	8	&	&	CCONJ
admet-2268	235	9	dmpk	dmpk	PROPN
admet-2268	235	10	12(3	12(3	PROPN
admet-2268	235	11	)	)	PUNCT
admet-2268	235	12	(	(	PUNCT
admet-2268	235	13	2024	2024	NUM
admet-2268	235	14	)	)	PUNCT
admet-2268	235	15	553	553	NUM
admet-2268	235	16	-	-	SYM
admet-2268	235	17	580	580	NUM
admet-2268	235	18	564	564	NUM
admet-2268	235	19	table	table	NOUN
admet-2268	235	20	3	3	NUM
admet-2268	235	21	.	.	PUNCT
admet-2268	235	22	actual	actual	ADJ
admet-2268	235	23	and	and	CCONJ
admet-2268	235	24	predicted	predict	VERB
admet-2268	235	25	values	value	NOUN
admet-2268	235	26	for	for	ADP
admet-2268	235	27	all	all	DET
admet-2268	235	28	response	response	NOUN
admet-2268	235	29	variables	variable	NOUN
admet-2268	235	30	for	for	ADP
admet-2268	235	31	different	different	ADJ
admet-2268	235	32	batches	batch	NOUN
admet-2268	235	33	.	.	PUNCT
admet-2268	236	1	formulation	formulation	NOUN
admet-2268	236	2	code	code	NOUN
admet-2268	236	3	mean	mean	NOUN
admet-2268	236	4	particle	particle	NOUN
admet-2268	236	5	size	size	NOUN
admet-2268	236	6	,	,	PUNCT
admet-2268	236	7	nm	nm	PRON
admet-2268	236	8	encapsulation	encapsulation	NOUN
admet-2268	236	9	efficiency	efficiency	NOUN
admet-2268	236	10	,	,	PUNCT
admet-2268	236	11	%	%	NOUN
admet-2268	236	12	berberine	berberine	PROPN
admet-2268	236	13	hcl	hcl	PROPN
admet-2268	236	14	diacerein	diacerein	PROPN
admet-2268	236	15	actual	actual	ADJ
admet-2268	236	16	predicted	predict	VERB
admet-2268	236	17	actual	actual	ADJ
admet-2268	236	18	predicted	predict	VERB
admet-2268	236	19	actual	actual	ADJ
admet-2268	236	20	predicted	predict	VERB
admet-2268	236	21	ddt-1	ddt-1	SYM
admet-2268	236	22	95.93	95.93	NUM
admet-2268	236	23	95.08	95.08	NUM
admet-2268	236	24	69.00	69.00	NUM
admet-2268	236	25	71.12	71.12	NUM
admet-2268	236	26	71.00	71.00	NUM
admet-2268	236	27	73.75	73.75	NUM
admet-2268	236	28	ddt-2	ddt-2	PRON
admet-2268	236	29	118.45	118.45	NUM
admet-2268	236	30	119.46	119.46	NUM
admet-2268	236	31	65.00	65.00	NUM
admet-2268	236	32	62.62	62.62	NUM
admet-2268	236	33	72.00	72.00	NUM
admet-2268	236	34	71.87	71.87	NUM
admet-2268	236	35	ddt-3	ddt-3	NUM
admet-2268	236	36	103.00	103.00	NUM
admet-2268	236	37	101.98	101.98	NUM
admet-2268	236	38	62.00	62.00	NUM
admet-2268	236	39	64.37	64.37	NUM
admet-2268	236	40	66.00	66.00	NUM
admet-2268	236	41	66.12	66.12	NUM
admet-2268	236	42	ddt-4	ddt-4	NUM
admet-2268	236	43	114.60	114.60	NUM
admet-2268	236	44	113.32	113.32	NUM
admet-2268	236	45	59.00	59.00	NUM
admet-2268	236	46	58.87	58.87	NUM
admet-2268	236	47	64.00	64.00	NUM
admet-2268	236	48	61.87	61.87	NUM
admet-2268	236	49	ddt-5	ddt-5	NUM
admet-2268	236	50	104.50	104.50	NUM
admet-2268	236	51	105.35	105.35	NUM
admet-2268	236	52	85.00	85.00	NUM
admet-2268	236	53	82.87	82.87	NUM
admet-2268	236	54	88.00	88.00	NUM
admet-2268	236	55	85.25	85.25	NUM
admet-2268	236	56	ddt-6	ddt-6	NUM
admet-2268	236	57	90.80	90.80	NUM
admet-2268	236	58	89.67	89.67	NUM
admet-2268	236	59	68.00	68.00	NUM
admet-2268	236	60	67.62	67.62	NUM
admet-2268	236	61	65.00	65.00	NUM
admet-2268	236	62	65.50	65.50	NUM
admet-2268	236	63	ddt-7	ddt-7	NUM
admet-2268	236	64	99.90	99.90	NUM
admet-2268	236	65	99.74	99.74	NUM
admet-2268	236	66	64.00	64.00	NUM
admet-2268	236	67	64.25	64.25	NUM
admet-2268	236	68	69.00	69.00	NUM
admet-2268	236	69	66.37	66.37	NUM
admet-2268	236	70	ddt-8	ddt-8	NUM
admet-2268	236	71	119.00	119.00	NUM
admet-2268	236	72	116.86	116.86	NUM
admet-2268	236	73	72.00	72.00	NUM
admet-2268	236	74	74.00	74.00	NUM
admet-2268	236	75	84.00	84.00	NUM
admet-2268	236	76	84.62	84.62	NUM
admet-2268	236	77	ddt-9	ddt-9	NUM
admet-2268	236	78	106.90	106.90	NUM
admet-2268	236	79	108.18	108.18	NUM
admet-2268	236	80	60.00	60.00	NUM
admet-2268	236	81	60.12	60.12	NUM
admet-2268	236	82	61.00	61.00	NUM
admet-2268	236	83	63.12	63.12	NUM
admet-2268	236	84	ddt-10	ddt-10	VERB
admet-2268	236	85	110.90	110.90	NUM
admet-2268	236	86	110.9	110.9	NUM
admet-2268	236	87	89.00	89.00	NUM
admet-2268	236	88	89.00	89.00	NUM
admet-2268	236	89	90.85	90.85	NUM
admet-2268	236	90	90.85	90.85	NUM
admet-2268	236	91	ddt-11	ddt-11	NUM
admet-2268	236	92	115.00	115.00	NUM
admet-2268	236	93	115.15	115.15	NUM
admet-2268	236	94	75.00	75.00	NUM
admet-2268	236	95	74.75	74.75	NUM
admet-2268	236	96	74.00	74.00	NUM
admet-2268	236	97	76.62	76.62	NUM
admet-2268	236	98	ddt-12	ddt-12	NOUN
admet-2268	236	99	86.98	86.98	NUM
admet-2268	236	100	89.11	89.11	NUM
admet-2268	236	101	66.00	66.00	NUM
admet-2268	236	102	64.00	64.00	NUM
admet-2268	236	103	68.00	68.00	NUM
admet-2268	236	104	67.37	67.37	NUM
admet-2268	236	105	ddt-13	ddt-13	NUM
admet-2268	236	106	121.45	121.45	NUM
admet-2268	236	107	122.57	122.57	NUM
admet-2268	236	108	76.00	76.00	NUM
admet-2268	236	109	76.37	76.37	NUM
admet-2268	236	110	82.00	82.00	NUM
admet-2268	236	111	81.50	81.50	NUM
admet-2268	236	112	figure	figure	NOUN
admet-2268	236	113	4	4	NUM
admet-2268	236	114	.	.	PUNCT
admet-2268	237	1	interaction	interaction	NOUN
admet-2268	237	2	plots	plot	NOUN
admet-2268	237	3	showing	show	VERB
admet-2268	237	4	probable	probable	ADJ
admet-2268	237	5	interaction	interaction	NOUN
admet-2268	237	6	between	between	ADP
admet-2268	237	7	the	the	DET
admet-2268	237	8	amount	amount	NOUN
admet-2268	237	9	of	of	ADP
admet-2268	237	10	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	237	11	(	(	PUNCT
admet-2268	237	12	phospholipid	phospholipid	NOUN
admet-2268	237	13	)	)	PUNCT
admet-2268	237	14	and	and	CCONJ
admet-2268	237	15	amount	amount	NOUN
admet-2268	237	16	of	of	ADP
admet-2268	237	17	sodium	sodium	NOUN
admet-2268	237	18	deoxycholate	deoxycholate	ADJ
admet-2268	237	19	(	(	PUNCT
admet-2268	237	20	edge	edge	NOUN
admet-2268	237	21	activator	activator	NOUN
admet-2268	237	22	)	)	PUNCT
admet-2268	237	23	,	,	PUNCT
admet-2268	237	24	sonication	sonication	NOUN
admet-2268	237	25	time	time	NOUN
admet-2268	237	26	and	and	CCONJ
admet-2268	237	27	amount	amount	NOUN
admet-2268	237	28	of	of	ADP
admet-2268	237	29	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	237	30	,	,	PUNCT
admet-2268	237	31	and	and	CCONJ
admet-2268	237	32	sonication	sonication	NOUN
admet-2268	237	33	time	time	NOUN
admet-2268	237	34	and	and	CCONJ
admet-2268	237	35	amount	amount	NOUN
admet-2268	237	36	of	of	ADP
admet-2268	237	37	sodium	sodium	NOUN
admet-2268	237	38	deoxycholate	deoxycholate	VERB
admet-2268	237	39	affecting	affect	VERB
admet-2268	237	40	particle	particle	NOUN
admet-2268	237	41	size	size	NOUN
admet-2268	237	42	(	(	PUNCT
admet-2268	237	43	i	i	NOUN
admet-2268	237	44	)	)	PUNCT
admet-2268	237	45	,	,	PUNCT
admet-2268	237	46	entrapment	entrapment	ADJ
admet-2268	237	47	efficiency	efficiency	NOUN
admet-2268	237	48	of	of	ADP
admet-2268	237	49	berberine	berberine	NOUN
admet-2268	237	50	hcl	hcl	PROPN
admet-2268	237	51	(	(	PUNCT
admet-2268	237	52	ii	ii	PROPN
admet-2268	237	53	)	)	PUNCT
admet-2268	237	54	,	,	PUNCT
admet-2268	237	55	and	and	CCONJ
admet-2268	237	56	entrapment	entrapment	ADJ
admet-2268	237	57	efficiency	efficiency	NOUN
admet-2268	237	58	of	of	ADP
admet-2268	237	59	diacerein	diacerein	ADJ
admet-2268	237	60	(	(	PUNCT
admet-2268	237	61	iii	iii	NOUN
admet-2268	237	62	)	)	PUNCT
admet-2268	237	63	.	.	PUNCT
admet-2268	238	1	admet	admet	PROPN
admet-2268	238	2	&	&	CCONJ
admet-2268	238	3	dmpk	dmpk	PROPN
admet-2268	238	4	12(3	12(3	PROPN
admet-2268	238	5	)	)	PUNCT
admet-2268	238	6	(	(	PUNCT
admet-2268	238	7	2024	2024	NUM
admet-2268	238	8	)	)	PUNCT
admet-2268	238	9	553	553	NUM
admet-2268	238	10	-	-	SYM
admet-2268	238	11	580	580	NUM
admet-2268	238	12	berberine	berberine	NOUN
admet-2268	238	13	hcl	hcl	PROPN
admet-2268	238	14	and	and	CCONJ
admet-2268	238	15	diacerein	diacerein	ADV
admet-2268	238	16	loaded	load	VERB
admet-2268	238	17	dual	dual	ADJ
admet-2268	238	18	delivery	delivery	NOUN
admet-2268	238	19	transferosomes	transferosome	NOUN
admet-2268	238	20	doi	doi	PROPN
admet-2268	238	21	:	:	PUNCT
admet-2268	238	22	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	238	23	565	565	NUM
admet-2268	238	24	sonication	sonication	NOUN
admet-2268	238	25	time	time	NOUN
admet-2268	238	26	showed	show	VERB
admet-2268	238	27	a	a	DET
admet-2268	238	28	suppressive	suppressive	ADJ
admet-2268	238	29	effect	effect	NOUN
admet-2268	238	30	on	on	ADP
admet-2268	238	31	entrapment	entrapment	ADJ
admet-2268	238	32	efficiency	efficiency	NOUN
admet-2268	238	33	.	.	PUNCT
admet-2268	239	1	the	the	DET
admet-2268	239	2	combination	combination	NOUN
admet-2268	239	3	of	of	ADP
admet-2268	239	4	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	239	5	and	and	CCONJ
admet-2268	239	6	sodium	sodium	NOUN
admet-2268	239	7	deoxycholate	deoxycholate	ADJ
admet-2268	239	8	(	(	PUNCT
admet-2268	239	9	ab	ab	NOUN
admet-2268	239	10	)	)	PUNCT
admet-2268	239	11	significantly	significantly	ADV
admet-2268	239	12	influenced	influence	VERB
admet-2268	239	13	the	the	DET
admet-2268	239	14	entrapment	entrapment	NOUN
admet-2268	239	15	of	of	ADP
admet-2268	239	16	berberine	berberine	NOUN
admet-2268	239	17	hcl	hcl	PROPN
admet-2268	239	18	(	(	PUNCT
admet-2268	239	19	f	f	PROPN
admet-2268	239	20	value	value	NOUN
admet-2268	239	21	2.61	2.61	NUM
admet-2268	239	22	and	and	CCONJ
admet-2268	239	23	p	p	NOUN
admet-2268	239	24	value	value	NOUN
admet-2268	239	25	0.2047	0.2047	NUM
admet-2268	239	26	)	)	PUNCT
admet-2268	239	27	.	.	PUNCT
admet-2268	240	1	while	while	SCONJ
admet-2268	240	2	the	the	DET
admet-2268	240	3	combination	combination	NOUN
admet-2268	240	4	of	of	ADP
admet-2268	240	5	sodium	sodium	NOUN
admet-2268	240	6	deoxycholate	deoxycholate	ADJ
admet-2268	240	7	and	and	CCONJ
admet-2268	240	8	sonication	sonication	NOUN
admet-2268	240	9	time	time	NOUN
admet-2268	240	10	(	(	PUNCT
admet-2268	240	11	bc	bc	PROPN
admet-2268	240	12	)	)	PUNCT
admet-2268	240	13	significantly	significantly	ADV
admet-2268	240	14	influenced	influence	VERB
admet-2268	240	15	the	the	DET
admet-2268	240	16	entrapment	entrapment	NOUN
admet-2268	240	17	of	of	ADP
admet-2268	240	18	diacerein	diacerein	ADJ
admet-2268	240	19	(	(	PUNCT
admet-2268	240	20	f	f	PROPN
admet-2268	240	21	value	value	NOUN
admet-2268	240	22	3.23	3.23	NUM
admet-2268	240	23	and	and	CCONJ
admet-2268	240	24	p	p	NOUN
admet-2268	240	25	value	value	NOUN
admet-2268	240	26	0.1702	0.1702	NUM
admet-2268	240	27	)	)	PUNCT
admet-2268	240	28	.	.	PUNCT
admet-2268	241	1	no	no	DET
admet-2268	241	2	interaction	interaction	NOUN
admet-2268	241	3	was	be	AUX
admet-2268	241	4	observed	observe	VERB
admet-2268	241	5	between	between	ADP
admet-2268	241	6	the	the	DET
admet-2268	241	7	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	241	8	amount	amount	NOUN
admet-2268	241	9	and	and	CCONJ
admet-2268	241	10	sonication	sonication	NOUN
admet-2268	241	11	time	time	NOUN
admet-2268	241	12	(	(	PUNCT
admet-2268	241	13	ac	ac	PROPN
admet-2268	241	14	)	)	PUNCT
admet-2268	241	15	on	on	ADP
admet-2268	241	16	the	the	DET
admet-2268	241	17	entrapment	entrapment	NOUN
admet-2268	241	18	of	of	ADP
admet-2268	241	19	berberine	berberine	PROPN
admet-2268	241	20	hcl	hcl	PROPN
admet-2268	241	21	.	.	PUNCT
admet-2268	242	1	in	in	ADP
admet-2268	242	2	comparison	comparison	NOUN
admet-2268	242	3	to	to	ADP
admet-2268	242	4	the	the	DET
admet-2268	242	5	effect	effect	NOUN
admet-2268	242	6	of	of	ADP
admet-2268	242	7	the	the	DET
admet-2268	242	8	combination	combination	NOUN
admet-2268	242	9	of	of	ADP
admet-2268	242	10	variables	variable	NOUN
admet-2268	242	11	,	,	PUNCT
admet-2268	242	12	the	the	DET
admet-2268	242	13	influence	influence	NOUN
admet-2268	242	14	squared	square	VERB
admet-2268	242	15	form	form	NOUN
admet-2268	242	16	of	of	ADP
admet-2268	242	17	sodium	sodium	NOUN
admet-2268	242	18	deoxycholate	deoxycholate	NOUN
admet-2268	242	19	amount	amount	NOUN
admet-2268	242	20	(	(	PUNCT
admet-2268	242	21	b2	b2	NOUN
admet-2268	242	22	)	)	PUNCT
admet-2268	242	23	and	and	CCONJ
admet-2268	242	24	sonication	sonication	NOUN
admet-2268	242	25	time	time	NOUN
admet-2268	242	26	(	(	PUNCT
admet-2268	242	27	c2	c2	PROPN
admet-2268	242	28	)	)	PUNCT
admet-2268	242	29	had	have	VERB
admet-2268	242	30	a	a	DET
admet-2268	242	31	higher	high	ADJ
admet-2268	242	32	effect	effect	NOUN
admet-2268	242	33	on	on	ADP
admet-2268	242	34	the	the	DET
admet-2268	242	35	entrapment	entrapment	NOUN
admet-2268	242	36	of	of	ADP
admet-2268	242	37	berberine	berberine	NOUN
admet-2268	242	38	hcl	hcl	PROPN
admet-2268	242	39	(	(	PUNCT
admet-2268	242	40	f	f	PROPN
admet-2268	242	41	value	value	NOUN
admet-2268	242	42	29.52	29.52	NUM
admet-2268	242	43	and	and	CCONJ
admet-2268	242	44	63.95	63.95	NUM
admet-2268	242	45	,	,	PUNCT
admet-2268	242	46	respectively	respectively	ADV
admet-2268	242	47	)	)	PUNCT
admet-2268	242	48	and	and	CCONJ
admet-2268	242	49	diacerein	diacerein	ADJ
admet-2268	242	50	(	(	PUNCT
admet-2268	242	51	f	f	PROPN
admet-2268	242	52	value	value	NOUN
admet-2268	242	53	21.82	21.82	NUM
admet-2268	242	54	and	and	CCONJ
admet-2268	242	55	33.88	33.88	NUM
admet-2268	242	56	,	,	PUNCT
admet-2268	242	57	respectively	respectively	ADV
admet-2268	242	58	)	)	PUNCT
admet-2268	242	59	.	.	PUNCT
admet-2268	243	1	the	the	DET
admet-2268	243	2	model	model	NOUN
admet-2268	243	3	reliability	reliability	NOUN
admet-2268	243	4	and	and	CCONJ
admet-2268	243	5	precision	precision	NOUN
admet-2268	243	6	were	be	AUX
admet-2268	243	7	confirmed	confirm	VERB
admet-2268	243	8	using	use	VERB
admet-2268	243	9	the	the	DET
admet-2268	243	10	coefficient	coefficient	NOUN
admet-2268	243	11	of	of	ADP
admet-2268	243	12	variation	variation	NOUN
admet-2268	243	13	(	(	PUNCT
admet-2268	243	14	table	table	NOUN
admet-2268	243	15	4	4	NUM
admet-2268	243	16	)	)	PUNCT
admet-2268	243	17	.	.	PUNCT
admet-2268	244	1	table	table	NOUN
admet-2268	244	2	4	4	NUM
admet-2268	244	3	.	.	PUNCT
admet-2268	244	4	results	result	NOUN
admet-2268	244	5	of	of	ADP
admet-2268	244	6	one	one	NUM
admet-2268	244	7	way	way	NOUN
admet-2268	244	8	anova	anova	X
admet-2268	244	9	for	for	ADP
admet-2268	244	10	particle	particle	NOUN
admet-2268	244	11	size	size	NOUN
admet-2268	244	12	and	and	CCONJ
admet-2268	244	13	entrapment	entrapment	ADJ
admet-2268	244	14	efficiency	efficiency	NOUN
admet-2268	244	15	of	of	ADP
admet-2268	244	16	berberine	berberine	NOUN
admet-2268	244	17	hcl	hcl	PROPN
admet-2268	244	18	and	and	CCONJ
admet-2268	244	19	diacerein	diacerein	ADJ
admet-2268	244	20	in	in	ADP
admet-2268	244	21	transferosomes	transferosome	NOUN
admet-2268	244	22	optimized	optimize	VERB
admet-2268	244	23	by	by	ADP
admet-2268	244	24	box	box	NOUN
admet-2268	244	25	behnken	behnken	PROPN
admet-2268	244	26	design	design	NOUN
admet-2268	244	27	.	.	PUNCT
admet-2268	245	1	response	response	NOUN
admet-2268	245	2	source	source	NOUN
admet-2268	245	3	sum	sum	NOUN
admet-2268	245	4	of	of	ADP
admet-2268	245	5	squares	square	NOUN
admet-2268	245	6	mean	mean	VERB
admet-2268	245	7	square	square	ADJ
admet-2268	245	8	f	f	NOUN
admet-2268	245	9	-	-	PUNCT
admet-2268	245	10	value	value	NOUN
admet-2268	245	11	p	p	NOUN
admet-2268	245	12	-	-	PUNCT
admet-2268	245	13	value	value	NOUN
admet-2268	245	14	y1	y1	NOUN
admet-2268	245	15	particle	particle	NOUN
admet-2268	245	16	size	size	NOUN
admet-2268	245	17	(	(	PUNCT
admet-2268	245	18	reduced	reduce	VERB
admet-2268	245	19	quadratic	quadratic	ADJ
admet-2268	245	20	model	model	NOUN
admet-2268	245	21	)	)	PUNCT
admet-2268	245	22	model	model	NOUN
admet-2268	245	23	1459.88	1459.88	NUM
admet-2268	245	24	162.21	162.21	NUM
admet-2268	245	25	26.37	26.37	NUM
admet-2268	245	26	0.0105	0.0105	NUM
admet-2268	245	27	*	*	PUNCT
admet-2268	245	28	a	a	DET
admet-2268	245	29	931.82	931.82	NUM
admet-2268	245	30	931.82	931.82	NUM
admet-2268	245	31	151.47	151.47	NUM
admet-2268	245	32	0.0012	0.0012	NUM
admet-2268	245	33	b	b	PROPN
admet-2268	245	34	255.72	255.72	NUM
admet-2268	245	35	255.72	255.72	NUM
admet-2268	245	36	41.57	41.57	NUM
admet-2268	246	1	0.0076	0.0076	NUM
admet-2268	246	2	c	c	PROPN
admet-2268	246	3	76.08	76.08	NUM
admet-2268	246	4	76.08	76.08	NUM
admet-2268	246	5	12.37	12.37	NUM
admet-2268	246	6	0.0390	0.0390	NUM
admet-2268	246	7	ab	ab	PROPN
admet-2268	246	8	34.93	34.93	NUM
admet-2268	246	9	34.93	34.93	NUM
admet-2268	246	10	5.68	5.68	NUM
admet-2268	246	11	0.0974	0.0974	NUM
admet-2268	246	12	ac	ac	PROPN
admet-2268	246	13	19.89	19.89	NUM
admet-2268	246	14	19.89	19.89	NUM
admet-2268	246	15	3.23	3.23	NUM
admet-2268	246	16	0.1700	0.1700	NUM
admet-2268	246	17	bc	bc	PROPN
admet-2268	246	18	0.0006	0.0006	NUM
admet-2268	246	19	0.0006	0.0006	NUM
admet-2268	246	20	0.0001	0.0001	NUM
admet-2268	246	21	0.9926	0.9926	NUM
admet-2268	246	22	a2	a2	NOUN
admet-2268	246	23	100.28	100.28	NUM
admet-2268	246	24	100.28	100.28	NUM
admet-2268	246	25	16.30	16.30	NUM
admet-2268	246	26	0.0273	0.0273	NUM
admet-2268	246	27	b2	b2	NOUN
admet-2268	246	28	2.80	2.80	NUM
admet-2268	246	29	2.80	2.80	NUM
admet-2268	246	30	0.4547	0.4547	NUM
admet-2268	246	31	0.5484	0.5484	NUM
admet-2268	246	32	c2	c2	PROPN
admet-2268	246	33	2.04	2.04	NUM
admet-2268	246	34	2.04	2.04	NUM
admet-2268	246	35	0.3309	0.3309	NUM
admet-2268	246	36	0.6054	0.6054	NUM
admet-2268	246	37	residual	residual	ADJ
admet-2268	246	38	18.46	18.46	NUM
admet-2268	246	39	6.15	6.15	NUM
admet-2268	246	40	cor	cor	PROPN
admet-2268	246	41	total	total	ADJ
admet-2268	246	42	1478.34	1478.34	NUM
admet-2268	246	43	y2	y2	NOUN
admet-2268	246	44	entrapment	entrapment	ADJ
admet-2268	246	45	efficiency	efficiency	NOUN
admet-2268	246	46	of	of	ADP
admet-2268	246	47	berberine	berberine	NOUN
admet-2268	246	48	hcl	hcl	PROPN
admet-2268	246	49	model	model	NOUN
admet-2268	246	50	989.25	989.25	NUM
admet-2268	246	51	109.92	109.92	NUM
admet-2268	246	52	11.47	11.47	NUM
admet-2268	246	53	0.0347	0.0347	NUM
admet-2268	246	54	*	*	PUNCT
admet-2268	246	55	a	a	DET
admet-2268	246	56	210.13	210.13	NUM
admet-2268	246	57	210.13	210.13	NUM
admet-2268	246	58	21.93	21.93	NUM
admet-2268	246	59	0.0184	0.0184	NUM
admet-2268	246	60	b	b	PROPN
admet-2268	246	61	4.50	4.50	NUM
admet-2268	246	62	4.50	4.50	NUM
admet-2268	246	63	0.4696	0.4696	NUM
admet-2268	246	64	0.5424	0.5424	NUM
admet-2268	246	65	c	c	NOUN
admet-2268	246	66	0.1250	0.1250	NUM
admet-2268	246	67	0.1250	0.1250	NUM
admet-2268	246	68	0.0130	0.0130	NUM
admet-2268	246	69	0.9163	0.9163	NUM
admet-2268	246	70	ab	ab	NOUN
admet-2268	246	71	25.00	25.00	NUM
admet-2268	246	72	25.00	25.00	NUM
admet-2268	246	73	2.61	2.61	NUM
admet-2268	246	74	0.2047	0.2047	NUM
admet-2268	246	75	ac	ac	PROPN
admet-2268	246	76	0.2500	0.2500	NUM
admet-2268	246	77	0.2500	0.2500	NUM
admet-2268	246	78	0.0261	0.0261	NUM
admet-2268	246	79	0.8820	0.8820	NUM
admet-2268	246	80	bc	bc	PROPN
admet-2268	246	81	16.00	16.00	NUM
admet-2268	246	82	16.00	16.00	NUM
admet-2268	246	83	1.67	1.67	NUM
admet-2268	246	84	0.2868	0.2868	NUM
admet-2268	246	85	a2	a2	PROPN
admet-2268	246	86	26.04	26.04	NUM
admet-2268	246	87	26.04	26.04	NUM
admet-2268	246	88	2.72	2.72	NUM
admet-2268	246	89	0.1979	0.1979	NUM
admet-2268	246	90	b2	b2	NOUN
admet-2268	246	91	282.89	282.89	NUM
admet-2268	246	92	282.89	282.89	NUM
admet-2268	246	93	29.52	29.52	NUM
admet-2268	246	94	0.0122	0.0122	NUM
admet-2268	246	95	c2	c2	PROPN
admet-2268	246	96	612.89	612.89	NUM
admet-2268	246	97	612.89	612.89	NUM
admet-2268	246	98	63.95	63.95	NUM
admet-2268	246	99	0.0041	0.0041	NUM
admet-2268	246	100	residual	residual	ADJ
admet-2268	246	101	28.75	28.75	NUM
admet-2268	246	102	9.58	9.58	NUM
admet-2268	246	103	cor	cor	X
admet-2268	246	104	total	total	ADJ
admet-2268	246	105	1018.00	1018.00	NUM
admet-2268	246	106	y3	y3	NOUN
admet-2268	246	107	entrapment	entrapment	ADJ
admet-2268	246	108	efficiency	efficiency	NOUN
admet-2268	246	109	of	of	ADP
admet-2268	246	110	diacerein	diacerein	ADJ
admet-2268	246	111	model	model	NOUN
admet-2268	246	112	1088.74	1088.74	NUM
admet-2268	246	113	120.97	120.97	NUM
admet-2268	246	114	9.25	9.25	NUM
admet-2268	246	115	0.0468	0.0468	NUM
admet-2268	246	116	*	*	PUNCT
admet-2268	246	117	a	a	DET
admet-2268	246	118	378.13	378.13	NUM
admet-2268	246	119	378.13	378.13	NUM
admet-2268	246	120	28.90	28.90	NUM
admet-2268	246	121	0.0126	0.0126	NUM
admet-2268	246	122	b	b	NOUN
admet-2268	246	123	10.13	10.13	NUM
admet-2268	246	124	10.13	10.13	NUM
admet-2268	246	125	0.7739	0.7739	NUM
admet-2268	246	126	0.4438	0.4438	NUM
admet-2268	246	127	c	c	NOUN
admet-2268	246	128	24.50	24.50	NUM
admet-2268	246	129	24.50	24.50	NUM
admet-2268	246	130	1.87	1.87	NUM
admet-2268	246	131	0.2646	0.2646	NUM
admet-2268	246	132	ab	ab	PROPN
admet-2268	246	133	36.00	36.00	NUM
admet-2268	246	134	36.00	36.00	NUM
admet-2268	246	135	2.75	2.75	NUM
admet-2268	246	136	0.1957	0.1957	NUM
admet-2268	246	137	ac	ac	PROPN
admet-2268	246	138	20.25	20.25	NUM
admet-2268	246	139	20.25	20.25	NUM
admet-2268	246	140	1.55	1.55	NUM
admet-2268	246	141	0.3018	0.3018	NUM
admet-2268	246	142	bc	bc	VERB
admet-2268	246	143	42.25	42.25	NUM
admet-2268	246	144	42.25	42.25	NUM
admet-2268	246	145	3.23	3.23	NUM
admet-2268	246	146	0.1702	0.1702	NUM
admet-2268	246	147	a2	a2	PROPN
admet-2268	246	148	23.04	23.04	NUM
admet-2268	246	149	23.04	23.04	NUM
admet-2268	246	150	1.76	1.76	NUM
admet-2268	246	151	0.2764	0.2764	NUM
admet-2268	246	152	b2	b2	NOUN
admet-2268	246	153	285.44	285.44	NUM
admet-2268	246	154	285.44	285.44	NUM
admet-2268	246	155	21.82	21.82	NUM
admet-2268	246	156	0.0185	0.0185	NUM
admet-2268	246	157	c2	c2	PROPN
admet-2268	246	158	443.21	443.21	NUM
admet-2268	246	159	443.21	443.21	NUM
admet-2268	246	160	33.88	33.88	NUM
admet-2268	246	161	0.0101	0.0101	NUM
admet-2268	246	162	residual	residual	ADJ
admet-2268	246	163	39.25	39.25	NUM
admet-2268	246	164	13.08	13.08	NUM
admet-2268	246	165	cor	cor	NOUN
admet-2268	246	166	total	total	NOUN
admet-2268	246	167	1127.99	1127.99	NUM
admet-2268	246	168	*	*	PUNCT
admet-2268	246	169	significant	significant	ADJ
admet-2268	246	170	values	value	NOUN
admet-2268	246	171	vesicle	vesicle	NOUN
admet-2268	246	172	size	size	NOUN
admet-2268	246	173	,	,	PUNCT
admet-2268	246	174	polydispersity	polydispersity	NOUN
admet-2268	246	175	index	index	NOUN
admet-2268	246	176	,	,	PUNCT
admet-2268	246	177	and	and	CCONJ
admet-2268	246	178	zeta	zeta	NOUN
admet-2268	246	179	potential	potential	NOUN
admet-2268	246	180	the	the	DET
admet-2268	246	181	particle	particle	NOUN
admet-2268	246	182	size	size	NOUN
admet-2268	246	183	of	of	ADP
admet-2268	246	184	the	the	DET
admet-2268	246	185	transferosomes	transferosome	NOUN
admet-2268	246	186	ranged	range	VERB
admet-2268	246	187	from	from	ADP
admet-2268	246	188	86.98±2.4	86.98±2.4	NUM
admet-2268	246	189	to	to	ADP
admet-2268	246	190	121.45±9.22	121.45±9.22	NUM
admet-2268	246	191	nm	nm	NOUN
admet-2268	246	192	,	,	PUNCT
admet-2268	246	193	while	while	SCONJ
admet-2268	246	194	the	the	DET
admet-2268	246	195	pdi	pdi	NOUN
admet-2268	246	196	ranged	range	VERB
admet-2268	246	197	from	from	ADP
admet-2268	246	198	0.244±0.014	0.244±0.014	PRON
admet-2268	246	199	to	to	ADP
admet-2268	246	200	0.452±0.008	0.452±0.008	NOUN
admet-2268	246	201	.	.	PUNCT
admet-2268	247	1	the	the	DET
admet-2268	247	2	optimized	optimize	VERB
admet-2268	247	3	formulation	formulation	NOUN
admet-2268	247	4	(	(	PUNCT
admet-2268	247	5	formulation	formulation	NOUN
admet-2268	247	6	ddt-10	ddt-10	NOUN
admet-2268	247	7	)	)	PUNCT
admet-2268	247	8	had	have	VERB
admet-2268	247	9	a	a	DET
admet-2268	247	10	particle	particle	NOUN
admet-2268	247	11	size	size	NOUN
admet-2268	247	12	of	of	ADP
admet-2268	247	13	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	247	14	s.	s.	PROPN
admet-2268	247	15	singh	singh	PROPN
admet-2268	247	16	and	and	CCONJ
admet-2268	247	17	r.	r.	PROPN
admet-2268	247	18	awasthi	awasthi	PROPN
admet-2268	247	19	admet	admet	PROPN
admet-2268	247	20	&	&	CCONJ
admet-2268	247	21	dmpk	dmpk	PROPN
admet-2268	247	22	12(3	12(3	PROPN
admet-2268	247	23	)	)	PUNCT
admet-2268	247	24	(	(	PUNCT
admet-2268	247	25	2024	2024	NUM
admet-2268	247	26	)	)	PUNCT
admet-2268	247	27	553	553	NUM
admet-2268	247	28	-	-	SYM
admet-2268	247	29	580	580	NUM
admet-2268	247	30	566	566	NUM
admet-2268	247	31	110.9±2.8	110.9±2.8	PROPN
admet-2268	247	32	nm	nm	NOUN
admet-2268	247	33	,	,	PUNCT
admet-2268	247	34	a	a	DET
admet-2268	247	35	pdi	pdi	NOUN
admet-2268	247	36	of	of	ADP
admet-2268	247	37	0.296	0.296	NUM
admet-2268	247	38	(	(	PUNCT
admet-2268	247	39	figure	figure	NOUN
admet-2268	247	40	5a	5a	NUM
admet-2268	247	41	)	)	PUNCT
admet-2268	247	42	,	,	PUNCT
admet-2268	247	43	and	and	CCONJ
admet-2268	247	44	a	a	DET
admet-2268	247	45	ζ	ζ	NOUN
admet-2268	247	46	potential	potential	NOUN
admet-2268	247	47	of	of	ADP
admet-2268	247	48	-13.3±0.6	-13.3±0.6	PROPN
admet-2268	247	49	mv	mv	PROPN
admet-2268	247	50	(	(	PUNCT
admet-2268	247	51	figure	figure	NOUN
admet-2268	247	52	5b	5b	NUM
admet-2268	247	53	)	)	PUNCT
admet-2268	247	54	.	.	PUNCT
admet-2268	248	1	the	the	DET
admet-2268	248	2	particle	particle	NOUN
admet-2268	248	3	size	size	NOUN
admet-2268	248	4	is	be	AUX
admet-2268	248	5	important	important	ADJ
admet-2268	248	6	for	for	ADP
admet-2268	248	7	cellular	cellular	ADJ
admet-2268	248	8	absorption	absorption	NOUN
admet-2268	248	9	and	and	CCONJ
admet-2268	248	10	colloidal	colloidal	NOUN
admet-2268	248	11	stability	stability	NOUN
admet-2268	248	12	,	,	PUNCT
admet-2268	248	13	and	and	CCONJ
admet-2268	248	14	the	the	DET
admet-2268	248	15	size	size	NOUN
admet-2268	248	16	distribution	distribution	NOUN
admet-2268	248	17	is	be	AUX
admet-2268	248	18	controlled	control	VERB
admet-2268	248	19	by	by	ADP
admet-2268	248	20	pdi	pdi	PROPN
admet-2268	248	21	.	.	PUNCT
admet-2268	249	1	the	the	DET
admet-2268	249	2	endocytosis	endocytosis	NOUN
admet-2268	249	3	process	process	NOUN
admet-2268	249	4	is	be	AUX
admet-2268	249	5	primarily	primarily	ADV
admet-2268	249	6	responsible	responsible	ADJ
admet-2268	249	7	for	for	ADP
admet-2268	249	8	nanoparticle	nanoparticle	NOUN
admet-2268	249	9	cellular	cellular	ADJ
admet-2268	249	10	uptake	uptake	NOUN
admet-2268	249	11	.	.	PUNCT
admet-2268	250	1	in	in	ADP
admet-2268	250	2	the	the	DET
admet-2268	250	3	case	case	NOUN
admet-2268	250	4	of	of	ADP
admet-2268	250	5	transdermal	transdermal	ADJ
admet-2268	250	6	distribution	distribution	NOUN
admet-2268	250	7	,	,	PUNCT
admet-2268	250	8	a	a	DET
admet-2268	250	9	particle	particle	NOUN
admet-2268	250	10	size	size	NOUN
admet-2268	250	11	of	of	ADP
admet-2268	250	12	less	less	ADJ
admet-2268	250	13	than	than	ADP
admet-2268	250	14	300	300	NUM
admet-2268	250	15	nm	nm	NOUN
admet-2268	250	16	is	be	AUX
admet-2268	250	17	easily	easily	ADV
admet-2268	250	18	deposited	deposit	VERB
admet-2268	250	19	into	into	ADP
admet-2268	250	20	the	the	DET
admet-2268	250	21	epidermis	epidermis	NOUN
admet-2268	250	22	and	and	CCONJ
admet-2268	250	23	dermis	dermis	NOUN
admet-2268	250	24	layers	layer	NOUN
admet-2268	250	25	of	of	ADP
admet-2268	250	26	the	the	DET
admet-2268	250	27	skin	skin	NOUN
admet-2268	250	28	and	and	CCONJ
admet-2268	250	29	may	may	AUX
admet-2268	250	30	even	even	ADV
admet-2268	250	31	reach	reach	VERB
admet-2268	250	32	the	the	DET
admet-2268	250	33	sub	sub	ADJ
admet-2268	250	34	-	-	ADJ
admet-2268	250	35	dermis	dermis	ADJ
admet-2268	250	36	layer	layer	NOUN
admet-2268	250	37	.	.	PUNCT
admet-2268	251	1	particles	particle	NOUN
admet-2268	251	2	within	within	ADP
admet-2268	251	3	the	the	DET
admet-2268	251	4	size	size	NOUN
admet-2268	251	5	range	range	NOUN
admet-2268	251	6	of	of	ADP
admet-2268	251	7	10	10	NUM
admet-2268	251	8	-	-	SYM
admet-2268	251	9	210	210	NUM
admet-2268	251	10	nm	nm	NOUN
admet-2268	251	11	can	can	AUX
admet-2268	251	12	penetrate	penetrate	VERB
admet-2268	251	13	through	through	ADP
admet-2268	251	14	a	a	DET
admet-2268	251	15	trans	trans	ADJ
admet-2268	251	16	-	-	ADJ
admet-2268	251	17	follicular	follicular	ADJ
admet-2268	251	18	pathway	pathway	NOUN
admet-2268	251	19	,	,	PUNCT
admet-2268	251	20	while	while	SCONJ
admet-2268	251	21	particles	particle	NOUN
admet-2268	251	22	smaller	small	ADJ
admet-2268	251	23	than	than	ADP
admet-2268	251	24	7	7	NUM
admet-2268	251	25	nm	nm	NOUN
admet-2268	251	26	can	can	AUX
admet-2268	251	27	penetrate	penetrate	VERB
admet-2268	251	28	by	by	ADP
admet-2268	251	29	lipidic	lipidic	ADJ
admet-2268	251	30	trans	tran	NOUN
admet-2268	251	31	-	-	ADJ
admet-2268	251	32	epidermal	epidermal	ADJ
admet-2268	251	33	channels	channel	NOUN
admet-2268	251	34	.	.	PUNCT
admet-2268	252	1	a	a	DET
admet-2268	252	2	pdi	pdi	NOUN
admet-2268	252	3	value	value	NOUN
admet-2268	252	4	exceeding	exceed	VERB
admet-2268	252	5	0.7	0.7	NUM
admet-2268	252	6	indicates	indicate	VERB
admet-2268	252	7	that	that	SCONJ
admet-2268	252	8	the	the	DET
admet-2268	252	9	system	system	NOUN
admet-2268	252	10	exhibits	exhibit	VERB
admet-2268	252	11	an	an	DET
admet-2268	252	12	undesirable	undesirable	ADJ
admet-2268	252	13	wider	wide	ADJ
admet-2268	252	14	range	range	NOUN
admet-2268	252	15	of	of	ADP
admet-2268	252	16	particle	particle	NOUN
admet-2268	252	17	sizes	size	NOUN
admet-2268	252	18	.	.	PUNCT
admet-2268	253	1	pdi	pdi	ADJ
admet-2268	253	2	values	value	NOUN
admet-2268	253	3	for	for	ADP
admet-2268	253	4	vesicular	vesicular	ADJ
admet-2268	253	5	nanoparticles	nanoparticle	NOUN
admet-2268	253	6	are	be	AUX
admet-2268	253	7	less	less	ADJ
admet-2268	253	8	than	than	ADP
admet-2268	253	9	0.3	0.3	NUM
admet-2268	253	10	,	,	PUNCT
admet-2268	253	11	suggesting	suggest	VERB
admet-2268	253	12	a	a	DET
admet-2268	253	13	homogenous	homogenous	ADJ
admet-2268	253	14	system	system	NOUN
admet-2268	253	15	and	and	CCONJ
admet-2268	253	16	reduced	reduced	ADJ
admet-2268	253	17	aggregation	aggregation	NOUN
admet-2268	254	1	[	[	X
admet-2268	254	2	13,36,37	13,36,37	NUM
admet-2268	254	3	]	]	X
admet-2268	254	4	.	.	PUNCT
admet-2268	255	1	a	a	DET
admet-2268	255	2	average	average	ADJ
admet-2268	255	3	particle	particle	NOUN
admet-2268	255	4	size	size	NOUN
admet-2268	255	5	:	:	PUNCT
admet-2268	255	6	110.9	110.9	NUM
admet-2268	255	7	nm	nm	ADJ
admet-2268	255	8	pdi	pdi	NOUN
admet-2268	255	9	=	=	SYM
admet-2268	255	10	0.296	0.296	NUM
admet-2268	255	11	intercept	intercept	NOUN
admet-2268	255	12	:	:	PUNCT
admet-2268	255	13	0.950	0.950	NUM
admet-2268	255	14	particle	particle	NOUN
admet-2268	255	15	size	size	NOUN
admet-2268	255	16	,	,	PUNCT
admet-2268	255	17	nm	nm	PRON
admet-2268	255	18	intensity	intensity	NOUN
admet-2268	255	19	,	,	PUNCT
admet-2268	255	20	%	%	NOUN
admet-2268	255	21	standard	standard	ADJ
admet-2268	255	22	deviation	deviation	NOUN
admet-2268	255	23	peak	peak	VERB
admet-2268	255	24	1	1	NUM
admet-2268	255	25	143.6	143.6	NUM
admet-2268	255	26	92.5	92.5	NUM
admet-2268	255	27	75.66	75.66	NUM
admet-2268	255	28	peak	peak	NOUN
admet-2268	255	29	2	2	NUM
admet-2268	255	30	25.77	25.77	NUM
admet-2268	255	31	4.0	4.0	NUM
admet-2268	255	32	4.836	4.836	NUM
admet-2268	255	33	peak	peak	NOUN
admet-2268	255	34	3	3	NUM
admet-2268	255	35	4659	4659	NUM
admet-2268	255	36	3.4	3.4	NUM
admet-2268	255	37	802.4	802.4	NUM
admet-2268	255	38	particle	particle	NOUN
admet-2268	255	39	size	size	NOUN
admet-2268	255	40	,	,	PUNCT
admet-2268	255	41	nm	nm	PROPN
admet-2268	255	42	b	b	NOUN
admet-2268	255	43	zeta	zeta	NOUN
admet-2268	255	44	potential	potential	ADJ
admet-2268	255	45	distribution	distribution	NOUN
admet-2268	255	46	,	,	PUNCT
admet-2268	255	47	mv	mv	PRON
admet-2268	255	48	figure	figure	VERB
admet-2268	255	49	5	5	NUM
admet-2268	255	50	.	.	PUNCT
admet-2268	256	1	results	result	NOUN
admet-2268	256	2	of	of	ADP
admet-2268	256	3	a	a	DET
admet-2268	256	4	particle	particle	NOUN
admet-2268	256	5	size	size	NOUN
admet-2268	256	6	distribution	distribution	NOUN
admet-2268	256	7	and	and	CCONJ
admet-2268	256	8	pdi	pdi	NOUN
admet-2268	256	9	and	and	CCONJ
admet-2268	256	10	b	b	NOUN
admet-2268	256	11	–	–	PUNCT
admet-2268	256	12	average	average	ADJ
admet-2268	256	13	zeta	zeta	NOUN
admet-2268	256	14	potential	potential	ADJ
admet-2268	256	15	analysis	analysis	NOUN
admet-2268	256	16	of	of	ADP
admet-2268	256	17	optimized	optimize	VERB
admet-2268	256	18	formulation	formulation	NOUN
admet-2268	256	19	(	(	PUNCT
admet-2268	256	20	formulation	formulation	NOUN
admet-2268	256	21	ddt-10	ddt-10	PROPN
admet-2268	256	22	)	)	PUNCT
admet-2268	256	23	(	(	PUNCT
admet-2268	256	24	test	test	NOUN
admet-2268	256	25	1	1	NUM
admet-2268	256	26	:	:	PUNCT
admet-2268	256	27	red	red	ADJ
admet-2268	256	28	,	,	PUNCT
admet-2268	256	29	test	test	NOUN
admet-2268	256	30	2	2	NUM
admet-2268	256	31	:	:	PUNCT
admet-2268	256	32	yellow	yellow	ADJ
admet-2268	256	33	,	,	PUNCT
admet-2268	256	34	test	test	NOUN
admet-2268	256	35	3	3	NUM
admet-2268	256	36	:	:	SYM
admet-2268	256	37	green	green	ADJ
admet-2268	256	38	)	)	PUNCT
admet-2268	256	39	.	.	PUNCT
admet-2268	257	1	transferosomes	transferosome	NOUN
admet-2268	257	2	acquire	acquire	VERB
admet-2268	257	3	their	their	PRON
admet-2268	257	4	flexibility	flexibility	NOUN
admet-2268	257	5	and	and	CCONJ
admet-2268	257	6	deformability	deformability	NOUN
admet-2268	257	7	characteristics	characteristic	NOUN
admet-2268	257	8	through	through	ADP
admet-2268	257	9	the	the	DET
admet-2268	257	10	destabilization	destabilization	NOUN
admet-2268	257	11	of	of	ADP
admet-2268	257	12	the	the	DET
admet-2268	257	13	lipid	lipid	NOUN
admet-2268	257	14	layers	layer	NOUN
admet-2268	257	15	induced	induce	VERB
admet-2268	257	16	by	by	ADP
admet-2268	257	17	the	the	DET
admet-2268	257	18	edge	edge	NOUN
admet-2268	257	19	activator	activator	NOUN
admet-2268	257	20	.	.	PUNCT
admet-2268	258	1	the	the	DET
admet-2268	258	2	reduction	reduction	NOUN
admet-2268	258	3	in	in	ADP
admet-2268	258	4	particle	particle	NOUN
admet-2268	258	5	size	size	NOUN
admet-2268	258	6	observed	observe	VERB
admet-2268	258	7	when	when	SCONJ
admet-2268	258	8	sodium	sodium	NOUN
admet-2268	258	9	deoxycholate	deoxycholate	NOUN
admet-2268	258	10	interacts	interact	VERB
admet-2268	258	11	with	with	ADP
admet-2268	258	12	lipid	lipid	ADJ
admet-2268	258	13	layers	layer	NOUN
admet-2268	258	14	can	can	AUX
admet-2268	258	15	be	be	AUX
admet-2268	258	16	attributed	attribute	VERB
admet-2268	258	17	to	to	ADP
admet-2268	258	18	its	its	PRON
admet-2268	258	19	negative	negative	ADJ
admet-2268	258	20	charge	charge	NOUN
admet-2268	258	21	.	.	PUNCT
admet-2268	259	1	the	the	DET
admet-2268	259	2	stability	stability	NOUN
admet-2268	259	3	of	of	ADP
admet-2268	259	4	a	a	DET
admet-2268	259	5	nanoparticle	nanoparticle	NOUN
admet-2268	259	6	system	system	NOUN
admet-2268	259	7	can	can	AUX
admet-2268	259	8	be	be	AUX
admet-2268	259	9	assured	assure	VERB
admet-2268	259	10	by	by	ADP
admet-2268	259	11	measuring	measure	VERB
admet-2268	259	12	its	its	PRON
admet-2268	259	13	zeta	zeta	NOUN
admet-2268	259	14	potential	potential	NOUN
admet-2268	259	15	,	,	PUNCT
admet-2268	259	16	which	which	PRON
admet-2268	259	17	offers	offer	VERB
admet-2268	259	18	information	information	NOUN
admet-2268	259	19	on	on	ADP
admet-2268	259	20	surface	surface	NOUN
admet-2268	259	21	charge	charge	NOUN
admet-2268	259	22	and	and	CCONJ
admet-2268	259	23	electrostatic	electrostatic	ADJ
admet-2268	259	24	repulsion	repulsion	NOUN
admet-2268	259	25	induced	induce	VERB
admet-2268	259	26	by	by	ADP
admet-2268	259	27	repulsive	repulsive	ADJ
admet-2268	259	28	energy	energy	NOUN
admet-2268	259	29	between	between	ADP
admet-2268	259	30	particles	particle	NOUN
admet-2268	259	31	.	.	PUNCT
admet-2268	260	1	when	when	SCONJ
admet-2268	260	2	the	the	DET
admet-2268	260	3	van	van	PROPN
admet-2268	260	4	der	der	NOUN
admet-2268	260	5	waals	waal	NOUN
admet-2268	260	6	forces	force	NOUN
admet-2268	260	7	within	within	ADP
admet-2268	260	8	the	the	DET
admet-2268	260	9	system	system	NOUN
admet-2268	260	10	become	become	VERB
admet-2268	260	11	dominant	dominant	ADJ
admet-2268	260	12	and	and	CCONJ
admet-2268	260	13	the	the	DET
admet-2268	260	14	electrostatic	electrostatic	ADJ
admet-2268	260	15	repulsion	repulsion	NOUN
admet-2268	260	16	increases	increase	NOUN
admet-2268	260	17	,	,	PUNCT
admet-2268	260	18	the	the	DET
admet-2268	260	19	system	system	NOUN
admet-2268	260	20	is	be	AUX
admet-2268	260	21	deemed	deem	VERB
admet-2268	260	22	to	to	PART
admet-2268	260	23	be	be	AUX
admet-2268	260	24	in	in	ADP
admet-2268	260	25	a	a	DET
admet-2268	260	26	stable	stable	ADJ
admet-2268	260	27	state	state	NOUN
admet-2268	260	28	.	.	PUNCT
admet-2268	261	1	ζ	ζ	NOUN
admet-2268	261	2	potential	potential	NOUN
admet-2268	261	3	is	be	AUX
admet-2268	261	4	influenced	influence	VERB
admet-2268	261	5	by	by	ADP
admet-2268	261	6	particle	particle	NOUN
admet-2268	261	7	distribution	distribution	NOUN
admet-2268	261	8	,	,	PUNCT
admet-2268	261	9	accumulation	accumulation	NOUN
admet-2268	261	10	,	,	PUNCT
admet-2268	261	11	and	and	CCONJ
admet-2268	261	12	flocculation	flocculation	NOUN
admet-2268	261	13	.	.	PUNCT
admet-2268	262	1	vesicular	vesicular	ADJ
admet-2268	262	2	structures	structure	NOUN
admet-2268	262	3	containing	contain	VERB
admet-2268	262	4	anionic	anionic	ADJ
admet-2268	262	5	surfactants	surfactant	NOUN
admet-2268	262	6	often	often	ADV
admet-2268	262	7	exhibit	exhibit	VERB
admet-2268	262	8	less	less	ADJ
admet-2268	262	9	aggregation	aggregation	NOUN
admet-2268	262	10	due	due	ADP
admet-2268	262	11	to	to	ADP
admet-2268	262	12	the	the	DET
admet-2268	262	13	presence	presence	NOUN
admet-2268	262	14	of	of	ADP
admet-2268	262	15	electrostatic	electrostatic	ADJ
admet-2268	262	16	repulsion	repulsion	NOUN
admet-2268	262	17	.	.	PUNCT
admet-2268	263	1	the	the	DET
admet-2268	263	2	ζ	ζ	PROPN
admet-2268	263	3	potential	potential	NOUN
admet-2268	263	4	of	of	ADP
admet-2268	263	5	transferosomes	transferosome	NOUN
admet-2268	263	6	is	be	AUX
admet-2268	263	7	steady	steady	ADJ
admet-2268	263	8	between	between	ADP
admet-2268	263	9	+30	+30	NOUN
admet-2268	263	10	and	and	CCONJ
admet-2268	263	11	-30	-30	NUM
admet-2268	263	12	mv	mv	PROPN
admet-2268	264	1	[	[	X
admet-2268	264	2	13,38	13,38	NUM
admet-2268	264	3	]	]	PUNCT
admet-2268	264	4	.	.	PUNCT
admet-2268	265	1	based	base	VERB
admet-2268	265	2	on	on	ADP
admet-2268	265	3	the	the	DET
admet-2268	265	4	outcomes	outcome	NOUN
admet-2268	265	5	of	of	ADP
admet-2268	265	6	our	our	PRON
admet-2268	265	7	investigation	investigation	NOUN
admet-2268	265	8	,	,	PUNCT
admet-2268	265	9	it	it	PRON
admet-2268	265	10	was	be	AUX
admet-2268	265	11	observed	observe	VERB
admet-2268	265	12	that	that	SCONJ
admet-2268	265	13	the	the	DET
admet-2268	265	14	optimized	optimize	VERB
admet-2268	265	15	formulation	formulation	NOUN
admet-2268	265	16	(	(	PUNCT
admet-2268	265	17	formulation	formulation	NOUN
admet-2268	265	18	ddt-10	ddt-10	NOUN
admet-2268	265	19	)	)	PUNCT
admet-2268	265	20	displayed	display	VERB
admet-2268	265	21	a	a	DET
admet-2268	265	22	uniform	uniform	ADJ
admet-2268	265	23	size	size	NOUN
admet-2268	265	24	distribution	distribution	NOUN
admet-2268	265	25	,	,	PUNCT
admet-2268	265	26	favorable	favorable	ADJ
admet-2268	265	27	stability	stability	NOUN
admet-2268	265	28	,	,	PUNCT
admet-2268	265	29	and	and	CCONJ
admet-2268	265	30	absence	absence	NOUN
admet-2268	265	31	of	of	ADP
admet-2268	265	32	aggregation	aggregation	NOUN
admet-2268	265	33	,	,	PUNCT
admet-2268	265	34	indicating	indicate	VERB
admet-2268	265	35	its	its	PRON
admet-2268	265	36	potential	potential	NOUN
admet-2268	265	37	for	for	ADP
admet-2268	265	38	skin	skin	NOUN
admet-2268	265	39	permeation	permeation	NOUN
admet-2268	265	40	.	.	PUNCT
admet-2268	266	1	in	in	ADP
admet-2268	266	2	te	te	PROPN
admet-2268	266	3	n	n	CCONJ
admet-2268	266	4	si	si	INTJ
admet-2268	267	1	ty	ty	INTJ
admet-2268	267	2	,	,	PUNCT
admet-2268	267	3	%	%	INTJ
admet-2268	267	4	r	r	NOUN
admet-2268	267	5	el	el	PROPN
admet-2268	267	6	at	at	ADP
admet-2268	267	7	iv	iv	NUM
admet-2268	267	8	e	e	NOUN
admet-2268	267	9	fr	fr	NOUN
admet-2268	267	10	eq	eq	ADP
admet-2268	267	11	u	u	PROPN
admet-2268	267	12	e	e	PROPN
admet-2268	267	13	n	n	PROPN
admet-2268	267	14	cy	cy	PROPN
admet-2268	267	15	admet	admet	PROPN
admet-2268	267	16	&	&	CCONJ
admet-2268	267	17	dmpk	dmpk	PROPN
admet-2268	267	18	12(3	12(3	PROPN
admet-2268	267	19	)	)	PUNCT
admet-2268	267	20	(	(	PUNCT
admet-2268	267	21	2024	2024	NUM
admet-2268	267	22	)	)	PUNCT
admet-2268	267	23	553	553	NUM
admet-2268	267	24	-	-	SYM
admet-2268	267	25	580	580	NUM
admet-2268	267	26	berberine	berberine	NOUN
admet-2268	267	27	hcl	hcl	PROPN
admet-2268	267	28	and	and	CCONJ
admet-2268	267	29	diacerein	diacerein	ADV
admet-2268	267	30	loaded	load	VERB
admet-2268	267	31	dual	dual	ADJ
admet-2268	267	32	delivery	delivery	NOUN
admet-2268	268	1	transferosomes	transferosome	NOUN
admet-2268	269	1	doi	doi	PROPN
admet-2268	269	2	:	:	PUNCT
admet-2268	269	3	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	269	4	567	567	NUM
admet-2268	269	5	fourier	fourier	ADV
admet-2268	269	6	-	-	PUNCT
admet-2268	269	7	transformed	transform	VERB
admet-2268	269	8	infrared	infrared	ADJ
admet-2268	269	9	analysis	analysis	NOUN
admet-2268	269	10	berberine	berberine	PROPN
admet-2268	269	11	hcl	hcl	PROPN
admet-2268	269	12	,	,	PUNCT
admet-2268	269	13	diacerein	diacerein	ADJ
admet-2268	269	14	,	,	PUNCT
admet-2268	269	15	their	their	PRON
admet-2268	269	16	physical	physical	ADJ
admet-2268	269	17	mixture	mixture	NOUN
admet-2268	269	18	,	,	PUNCT
admet-2268	269	19	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	269	20	,	,	PUNCT
admet-2268	269	21	and	and	CCONJ
admet-2268	269	22	sodium	sodium	NOUN
admet-2268	269	23	deoxycholate	deoxycholate	NOUN
admet-2268	269	24	were	be	AUX
admet-2268	269	25	subjected	subject	VERB
admet-2268	269	26	to	to	PART
admet-2268	269	27	ftir	ftir	VERB
admet-2268	269	28	analysis	analysis	NOUN
admet-2268	269	29	to	to	PART
admet-2268	269	30	determine	determine	VERB
admet-2268	269	31	the	the	DET
admet-2268	269	32	presence	presence	NOUN
admet-2268	269	33	of	of	ADP
admet-2268	269	34	the	the	DET
admet-2268	269	35	functional	functional	ADJ
admet-2268	269	36	groups	group	NOUN
admet-2268	269	37	and	and	CCONJ
admet-2268	269	38	their	their	PRON
admet-2268	269	39	interactions	interaction	NOUN
admet-2268	269	40	,	,	PUNCT
admet-2268	269	41	if	if	SCONJ
admet-2268	269	42	any	any	DET
admet-2268	269	43	(	(	PUNCT
admet-2268	269	44	figure	figure	NOUN
admet-2268	269	45	6	6	NUM
admet-2268	269	46	)	)	PUNCT
admet-2268	269	47	.	.	PUNCT
admet-2268	270	1	the	the	DET
admet-2268	270	2	characteristic	characteristic	ADJ
admet-2268	270	3	peaks	peak	NOUN
admet-2268	270	4	of	of	ADP
admet-2268	270	5	berberine	berberine	PROPN
admet-2268	270	6	hcl	hcl	PROPN
admet-2268	270	7	,	,	PUNCT
admet-2268	270	8	diacerein	diacerein	ADJ
admet-2268	270	9	,	,	PUNCT
admet-2268	270	10	a	a	DET
admet-2268	270	11	physical	physical	ADJ
admet-2268	270	12	mixture	mixture	NOUN
admet-2268	270	13	of	of	ADP
admet-2268	270	14	berberine	berberine	NOUN
admet-2268	270	15	hcl	hcl	PROPN
admet-2268	270	16	and	and	CCONJ
admet-2268	270	17	diacerein	diacerein	ADJ
admet-2268	270	18	,	,	PUNCT
admet-2268	270	19	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	270	20	,	,	PUNCT
admet-2268	270	21	and	and	CCONJ
admet-2268	270	22	sodium	sodium	NOUN
admet-2268	270	23	deoxycholate	deoxycholate	NOUN
admet-2268	270	24	are	be	AUX
admet-2268	270	25	presented	present	VERB
admet-2268	270	26	in	in	ADP
admet-2268	270	27	table	table	NOUN
admet-2268	270	28	5	5	NUM
admet-2268	270	29	.	.	PUNCT
admet-2268	271	1	no	no	DET
admet-2268	271	2	new	new	ADJ
admet-2268	271	3	peaks	peak	NOUN
admet-2268	271	4	were	be	AUX
admet-2268	271	5	identified	identify	VERB
admet-2268	271	6	,	,	PUNCT
admet-2268	271	7	and	and	CCONJ
admet-2268	271	8	both	both	DET
admet-2268	271	9	drugs	drug	NOUN
admet-2268	271	10	were	be	AUX
admet-2268	271	11	found	find	VERB
admet-2268	271	12	to	to	PART
admet-2268	271	13	be	be	AUX
admet-2268	271	14	compatible	compatible	ADJ
admet-2268	271	15	with	with	ADP
admet-2268	271	16	each	each	DET
admet-2268	271	17	other	other	ADJ
admet-2268	271	18	.	.	PUNCT
admet-2268	272	1	wavenumber	wavenumber	NOUN
admet-2268	272	2	,	,	PUNCT
admet-2268	272	3	cm-1	cm-1	NOUN
admet-2268	272	4	figure	figure	NOUN
admet-2268	272	5	6	6	NUM
admet-2268	272	6	.	.	PUNCT
admet-2268	272	7	ftir	ftir	PROPN
admet-2268	272	8	spectrum	spectrum	PROPN
admet-2268	272	9	of	of	ADP
admet-2268	272	10	:	:	PUNCT
admet-2268	272	11	a	a	DET
admet-2268	272	12	diacerein	diacerein	ADJ
admet-2268	272	13	,	,	PUNCT
admet-2268	272	14	b	b	PROPN
admet-2268	272	15	berberine	berberine	PROPN
admet-2268	272	16	hcl	hcl	PROPN
admet-2268	272	17	,	,	PUNCT
admet-2268	272	18	c	c	PROPN
admet-2268	272	19	a	a	DET
admet-2268	272	20	physical	physical	ADJ
admet-2268	272	21	mixture	mixture	NOUN
admet-2268	272	22	of	of	ADP
admet-2268	272	23	diacerein	diacerein	ADJ
admet-2268	272	24	and	and	CCONJ
admet-2268	272	25	berberine	berberine	PROPN
admet-2268	272	26	hcl	hcl	PROPN
admet-2268	272	27	,	,	PUNCT
admet-2268	272	28	d	d	PROPN
admet-2268	272	29	sodium	sodium	NOUN
admet-2268	272	30	deoxycholate	deoxycholate	VERB
admet-2268	272	31	,	,	PUNCT
admet-2268	272	32	e	e	X
admet-2268	272	33	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	272	34	and	and	CCONJ
admet-2268	272	35	f	f	PROPN
admet-2268	272	36	optimized	optimize	VERB
admet-2268	272	37	formulation	formulation	NOUN
admet-2268	272	38	(	(	PUNCT
admet-2268	272	39	formulation	formulation	NOUN
admet-2268	272	40	ddt-10	ddt-10	VERB
admet-2268	272	41	)	)	PUNCT
admet-2268	272	42	.	.	PUNCT
admet-2268	273	1	tr	tr	VERB
admet-2268	273	2	an	an	DET
admet-2268	273	3	sm	sm	NOUN
admet-2268	273	4	it	it	PRON
admet-2268	273	5	ta	ta	ADP
admet-2268	273	6	n	n	PROPN
admet-2268	273	7	ce	ce	PROPN
admet-2268	273	8	,	,	PUNCT
admet-2268	273	9	%	%	INTJ
admet-2268	273	10	tr	tr	VERB
admet-2268	273	11	an	an	DET
admet-2268	273	12	sm	sm	NOUN
admet-2268	273	13	it	it	PRON
admet-2268	273	14	ta	ta	ADP
admet-2268	273	15	n	n	PROPN
admet-2268	273	16	ce	ce	PROPN
admet-2268	273	17	,	,	PUNCT
admet-2268	273	18	%	%	NOUN
admet-2268	273	19	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	PROPN
admet-2268	273	20	s.	s.	PROPN
admet-2268	273	21	singh	singh	PROPN
admet-2268	273	22	and	and	CCONJ
admet-2268	273	23	r.	r.	PROPN
admet-2268	273	24	awasthi	awasthi	PROPN
admet-2268	273	25	admet	admet	PROPN
admet-2268	273	26	&	&	CCONJ
admet-2268	273	27	dmpk	dmpk	PROPN
admet-2268	273	28	12(3	12(3	PROPN
admet-2268	273	29	)	)	PUNCT
admet-2268	273	30	(	(	PUNCT
admet-2268	273	31	2024	2024	NUM
admet-2268	273	32	)	)	PUNCT
admet-2268	273	33	553	553	NUM
admet-2268	273	34	-	-	SYM
admet-2268	273	35	580	580	NUM
admet-2268	273	36	568	568	NUM
admet-2268	273	37	table	table	NOUN
admet-2268	273	38	5	5	NUM
admet-2268	273	39	.	.	PUNCT
admet-2268	273	40	functional	functional	ADJ
admet-2268	273	41	groups	group	NOUN
admet-2268	273	42	present	present	ADJ
admet-2268	273	43	in	in	ADP
admet-2268	273	44	berberine	berberine	PROPN
admet-2268	273	45	hcl	hcl	PROPN
admet-2268	273	46	,	,	PUNCT
admet-2268	273	47	diacerein	diacerein	ADJ
admet-2268	273	48	,	,	PUNCT
admet-2268	273	49	physical	physical	ADJ
admet-2268	273	50	mixture	mixture	NOUN
admet-2268	273	51	of	of	ADP
admet-2268	273	52	diacerein	diacerein	ADJ
admet-2268	273	53	and	and	CCONJ
admet-2268	273	54	berberine	berberine	PROPN
admet-2268	273	55	hcl	hcl	PROPN
admet-2268	273	56	,	,	PUNCT
admet-2268	273	57	sodium	sodium	NOUN
admet-2268	273	58	deoxycholate	deoxycholate	PROPN
admet-2268	273	59	,	,	PUNCT
admet-2268	273	60	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	273	61	,	,	PUNCT
admet-2268	273	62	and	and	CCONJ
admet-2268	273	63	optimized	optimize	VERB
admet-2268	273	64	formulation	formulation	NOUN
admet-2268	273	65	(	(	PUNCT
admet-2268	273	66	formulation	formulation	NOUN
admet-2268	273	67	ddt-10	ddt-10	NOUN
admet-2268	273	68	)	)	PUNCT
admet-2268	273	69	and	and	CCONJ
admet-2268	273	70	their	their	PRON
admet-2268	273	71	quantified	quantified	ADJ
admet-2268	273	72	frequencies	frequency	NOUN
admet-2268	273	73	.	.	PUNCT
admet-2268	274	1	sample	sample	NOUN
admet-2268	274	2	wavenumber	wavenumber	NOUN
admet-2268	274	3	,	,	PUNCT
admet-2268	274	4	cm-1	cm-1	PUNCT
admet-2268	274	5	remark	remark	NOUN
admet-2268	274	6	ref	ref	PROPN
admet-2268	274	7	.	.	PUNCT
admet-2268	275	1	berberine	berberine	PROPN
admet-2268	275	2	hcl	hcl	PROPN
admet-2268	275	3	2839	2839	NUM
admet-2268	275	4	c	c	NOUN
admet-2268	275	5	-	-	PUNCT
admet-2268	275	6	h	h	NOUN
admet-2268	275	7	stretching	stretch	VERB
admet-2268	276	1	[	[	PUNCT
admet-2268	276	2	39	39	NUM
admet-2268	276	3	-	-	SYM
admet-2268	276	4	42	42	NUM
admet-2268	276	5	]	]	PUNCT
admet-2268	276	6	1634	1634	NUM
admet-2268	276	7	iminium	iminium	NOUN
admet-2268	276	8	c	c	NOUN
admet-2268	276	9	=	=	NOUN
admet-2268	276	10	n+	n+	PRON
admet-2268	276	11	double	double	ADJ
admet-2268	276	12	bond	bond	NOUN
admet-2268	276	13	1598	1598	NUM
admet-2268	276	14	c	c	NOUN
admet-2268	277	1	=	=	SYM
admet-2268	277	2	c	c	NOUN
admet-2268	277	3	stretching	stretch	VERB
admet-2268	277	4	1271	1271	NUM
admet-2268	277	5	c	c	NOUN
admet-2268	277	6	-	-	PUNCT
admet-2268	277	7	o	o	NOUN
admet-2268	277	8	-	-	NOUN
admet-2268	277	9	c	c	NOUN
admet-2268	277	10	stretching	stretch	VERB
admet-2268	277	11	1223	1223	NUM
admet-2268	277	12	c	c	NOUN
admet-2268	277	13	-	-	PUNCT
admet-2268	277	14	o	o	NOUN
admet-2268	277	15	stretching	stretching	NOUN
admet-2268	277	16	diacerein	diacerein	ADJ
admet-2268	277	17	3341	3341	NUM
admet-2268	277	18	o	o	NOUN
admet-2268	277	19	-	-	ADJ
admet-2268	277	20	h	h	ADJ
admet-2268	277	21	stretching	stretch	VERB
admet-2268	277	22	band	band	NOUN
admet-2268	277	23	of	of	ADP
admet-2268	277	24	-cooh	-cooh	PROPN
admet-2268	277	25	[	[	X
admet-2268	277	26	42	42	NUM
admet-2268	277	27	-	-	SYM
admet-2268	277	28	45	45	NUM
admet-2268	277	29	]	]	PUNCT
admet-2268	277	30	2839	2839	NUM
admet-2268	277	31	c	c	X
admet-2268	277	32	-	-	PUNCT
admet-2268	277	33	h	h	NOUN
admet-2268	277	34	stretching	stretching	NOUN
admet-2268	277	35	of	of	ADP
admet-2268	277	36	an	an	DET
admet-2268	277	37	aliphatic	aliphatic	ADJ
admet-2268	277	38	symmetric	symmetric	ADJ
admet-2268	277	39	group	group	NOUN
admet-2268	277	40	1770	1770	NUM
admet-2268	277	41	c	c	NOUN
admet-2268	277	42	=	=	X
admet-2268	277	43	o	o	NOUN
admet-2268	277	44	stretching	stretch	VERB
admet-2268	277	45	band	band	NOUN
admet-2268	277	46	of	of	ADP
admet-2268	277	47	an	an	DET
admet-2268	277	48	ester	ester	NOUN
admet-2268	277	49	group	group	NOUN
admet-2268	277	50	1694	1694	NUM
admet-2268	277	51	c	c	NOUN
admet-2268	277	52	=	=	X
admet-2268	277	53	o	o	NOUN
admet-2268	277	54	stretching	stretch	VERB
admet-2268	277	55	band	band	NOUN
admet-2268	277	56	of	of	ADP
admet-2268	277	57	-cooh	-cooh	PROPN
admet-2268	277	58	1607	1607	PROPN
admet-2268	277	59	c	c	NOUN
admet-2268	277	60	=	=	NOUN
admet-2268	277	61	o	o	NOUN
admet-2268	277	62	stretching	stretching	NOUN
admet-2268	277	63	of	of	ADP
admet-2268	277	64	an	an	DET
admet-2268	277	65	aromatic	aromatic	ADJ
admet-2268	277	66	group	group	NOUN
admet-2268	277	67	1206	1206	NUM
admet-2268	277	68	c	c	NOUN
admet-2268	277	69	-	-	PUNCT
admet-2268	277	70	o	o	NOUN
admet-2268	277	71	stretching	stretch	VERB
admet-2268	277	72	physical	physical	ADJ
admet-2268	277	73	mixture	mixture	NOUN
admet-2268	277	74	of	of	ADP
admet-2268	277	75	berberine	berberine	NOUN
admet-2268	277	76	hcl	hcl	PROPN
admet-2268	277	77	and	and	CCONJ
admet-2268	277	78	diacerein	diacerein	VERB
admet-2268	277	79	3341	3341	NUM
admet-2268	277	80	o	o	NOUN
admet-2268	277	81	-	-	NOUN
admet-2268	277	82	h	h	NOUN
admet-2268	277	83	stretching	stretch	VERB
admet-2268	277	84	2845	2845	NUM
admet-2268	277	85	c	c	NOUN
admet-2268	277	86	-	-	PUNCT
admet-2268	277	87	h	h	NOUN
admet-2268	277	88	stretching	stretch	VERB
admet-2268	277	89	1770	1770	NUM
admet-2268	277	90	c	c	NOUN
admet-2268	277	91	=	=	X
admet-2268	277	92	o	o	NOUN
admet-2268	277	93	stretching	stretch	VERB
admet-2268	277	94	band	band	NOUN
admet-2268	277	95	of	of	ADP
admet-2268	277	96	an	an	DET
admet-2268	277	97	ester	ester	NOUN
admet-2268	277	98	group	group	NOUN
admet-2268	277	99	1694	1694	NUM
admet-2268	277	100	c	c	NOUN
admet-2268	277	101	=	=	X
admet-2268	277	102	o	o	NOUN
admet-2268	277	103	stretching	stretch	VERB
admet-2268	277	104	band	band	NOUN
admet-2268	277	105	of	of	ADP
admet-2268	277	106	-cooh	-cooh	ADJ
admet-2268	277	107	1634	1634	NUM
admet-2268	277	108	iminium	iminium	NOUN
admet-2268	277	109	c	c	NOUN
admet-2268	277	110	=	=	NOUN
admet-2268	277	111	n+	n+	PRON
admet-2268	277	112	double	double	ADJ
admet-2268	277	113	bond	bond	NOUN
admet-2268	277	114	1598	1598	NUM
admet-2268	277	115	c	c	NOUN
admet-2268	277	116	=	=	SYM
admet-2268	277	117	c	c	NOUN
admet-2268	277	118	stretching	stretch	VERB
admet-2268	277	119	1271	1271	NUM
admet-2268	277	120	c	c	NOUN
admet-2268	277	121	-	-	PUNCT
admet-2268	277	122	o	o	NOUN
admet-2268	277	123	-	-	NOUN
admet-2268	277	124	c	c	NOUN
admet-2268	277	125	stretching	stretch	VERB
admet-2268	277	126	1206	1206	NUM
admet-2268	277	127	c	c	NOUN
admet-2268	277	128	-	-	PUNCT
admet-2268	277	129	o	o	NOUN
admet-2268	277	130	stretching	stretch	VERB
admet-2268	277	131	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	277	132	2839	2839	NUM
admet-2268	277	133	c	c	NOUN
admet-2268	277	134	-	-	PUNCT
admet-2268	277	135	h	h	NOUN
admet-2268	277	136	stretching	stretching	NOUN
admet-2268	278	1	[	[	X
admet-2268	278	2	46,47	46,47	NOUN
admet-2268	278	3	]	]	PUNCT
admet-2268	278	4	1751	1751	NUM
admet-2268	278	5	c	c	X
admet-2268	278	6	=	=	SYM
admet-2268	278	7	o	o	X
admet-2268	278	8	stretching	stretch	VERB
admet-2268	278	9	1210	1210	NUM
admet-2268	278	10	p	p	X
admet-2268	278	11	=	=	X
admet-2268	278	12	o	o	X
admet-2268	278	13	stretching	stretch	VERB
admet-2268	278	14	1075	1075	NUM
admet-2268	278	15	p	p	NOUN
admet-2268	278	16	-	-	PUNCT
admet-2268	278	17	o	o	NOUN
admet-2268	278	18	-	-	NOUN
admet-2268	278	19	c	c	NOUN
admet-2268	278	20	stretching	stretch	VERB
admet-2268	278	21	sodium	sodium	NOUN
admet-2268	278	22	deoxycholate	deoxycholate	VERB
admet-2268	278	23	2857	2857	NUM
admet-2268	278	24	c	c	NOUN
admet-2268	278	25	-	-	PUNCT
admet-2268	278	26	h	h	NOUN
admet-2268	278	27	stretching	stretching	NOUN
admet-2268	278	28	[	[	X
admet-2268	278	29	48,49	48,49	X
admet-2268	278	30	]	]	PUNCT
admet-2268	278	31	1550	1550	NUM
admet-2268	278	32	coostretching	coostretche	VERB
admet-2268	278	33	formulation	formulation	NOUN
admet-2268	278	34	ddt-10	ddt-10	VERB
admet-2268	278	35	2995	2995	NUM
admet-2268	278	36	c	c	NOUN
admet-2268	278	37	-	-	PUNCT
admet-2268	278	38	h	h	NOUN
admet-2268	278	39	stretching	stretch	VERB
admet-2268	278	40	1770	1770	NUM
admet-2268	278	41	c	c	NOUN
admet-2268	278	42	=	=	X
admet-2268	278	43	o	o	NOUN
admet-2268	278	44	stretching	stretch	VERB
admet-2268	278	45	band	band	NOUN
admet-2268	278	46	of	of	ADP
admet-2268	278	47	an	an	DET
admet-2268	278	48	ester	ester	NOUN
admet-2268	278	49	group	group	NOUN
admet-2268	278	50	1694	1694	NUM
admet-2268	278	51	c	c	NOUN
admet-2268	278	52	=	=	X
admet-2268	278	53	o	o	NOUN
admet-2268	278	54	stretching	stretch	VERB
admet-2268	278	55	band	band	NOUN
admet-2268	278	56	of	of	ADP
admet-2268	278	57	-cooh	-cooh	ADJ
admet-2268	278	58	1634	1634	NUM
admet-2268	278	59	iminium	iminium	NOUN
admet-2268	278	60	c	c	NOUN
admet-2268	278	61	=	=	NOUN
admet-2268	278	62	n+	n+	PRON
admet-2268	278	63	double	double	ADJ
admet-2268	278	64	bond	bond	NOUN
admet-2268	278	65	1598	1598	NUM
admet-2268	278	66	c	c	NOUN
admet-2268	278	67	=	=	SYM
admet-2268	278	68	c	c	NOUN
admet-2268	278	69	stretching	stretch	VERB
admet-2268	278	70	1206	1206	NUM
admet-2268	278	71	c	c	NOUN
admet-2268	278	72	-	-	PUNCT
admet-2268	278	73	o	o	NOUN
admet-2268	278	74	stretching	stretch	VERB
admet-2268	278	75	1116	1116	NUM
admet-2268	278	76	p	p	X
admet-2268	278	77	=	=	X
admet-2268	278	78	o	o	X
admet-2268	278	79	stretching	stretch	VERB
admet-2268	278	80	x	x	NOUN
admet-2268	278	81	-	-	NOUN
admet-2268	278	82	ray	ray	NOUN
admet-2268	278	83	diffraction	diffraction	NOUN
admet-2268	278	84	analysis	analysis	NOUN
admet-2268	278	85	x	x	NOUN
admet-2268	278	86	-	-	NOUN
admet-2268	278	87	ray	ray	NOUN
admet-2268	278	88	diffraction	diffraction	NOUN
admet-2268	278	89	(	(	PUNCT
admet-2268	278	90	xrd	xrd	NOUN
admet-2268	278	91	)	)	PUNCT
admet-2268	278	92	analysis	analysis	NOUN
admet-2268	278	93	of	of	ADP
admet-2268	278	94	berberine	berberine	PROPN
admet-2268	278	95	hcl	hcl	PROPN
admet-2268	278	96	,	,	PUNCT
admet-2268	278	97	diacerein	diacerein	ADJ
admet-2268	278	98	,	,	PUNCT
admet-2268	278	99	a	a	DET
admet-2268	278	100	physical	physical	ADJ
admet-2268	278	101	mixture	mixture	NOUN
admet-2268	278	102	of	of	ADP
admet-2268	278	103	berberine	berberine	NOUN
admet-2268	278	104	hcl	hcl	PROPN
admet-2268	278	105	and	and	CCONJ
admet-2268	278	106	diacerein	diacerein	ADJ
admet-2268	278	107	,	,	PUNCT
admet-2268	278	108	and	and	CCONJ
admet-2268	278	109	optimized	optimize	VERB
admet-2268	278	110	formulation	formulation	NOUN
admet-2268	278	111	(	(	PUNCT
admet-2268	278	112	formulation	formulation	NOUN
admet-2268	278	113	ddt-10	ddt-10	NOUN
admet-2268	278	114	)	)	PUNCT
admet-2268	278	115	was	be	AUX
admet-2268	278	116	performed	perform	VERB
admet-2268	278	117	to	to	PART
admet-2268	278	118	assess	assess	VERB
admet-2268	278	119	the	the	DET
admet-2268	278	120	physical	physical	ADJ
admet-2268	278	121	form	form	NOUN
admet-2268	278	122	of	of	ADP
admet-2268	278	123	drugs	drug	NOUN
admet-2268	278	124	in	in	ADP
admet-2268	278	125	their	their	PRON
admet-2268	278	126	pure	pure	ADJ
admet-2268	278	127	form	form	NOUN
admet-2268	278	128	,	,	PUNCT
admet-2268	278	129	physical	physical	ADJ
admet-2268	278	130	mixture	mixture	NOUN
admet-2268	278	131	,	,	PUNCT
admet-2268	278	132	and	and	CCONJ
admet-2268	278	133	optimized	optimize	VERB
admet-2268	278	134	formulation	formulation	NOUN
admet-2268	278	135	.	.	PUNCT
admet-2268	279	1	the	the	DET
admet-2268	279	2	diffraction	diffraction	NOUN
admet-2268	279	3	angles	angle	VERB
admet-2268	279	4	and	and	CCONJ
admet-2268	279	5	sharp	sharp	ADJ
admet-2268	279	6	peaks	peak	NOUN
admet-2268	279	7	of	of	ADP
admet-2268	279	8	berberine	berberine	NOUN
admet-2268	279	9	hcl	hcl	PROPN
admet-2268	279	10	were	be	AUX
admet-2268	279	11	found	find	VERB
admet-2268	279	12	at	at	ADP
admet-2268	279	13	6.8	6.8	NUM
admet-2268	279	14	,	,	PUNCT
admet-2268	279	15	7.5	7.5	NUM
admet-2268	279	16	,	,	PUNCT
admet-2268	279	17	8.6	8.6	NUM
admet-2268	279	18	,	,	PUNCT
admet-2268	279	19	12.9	12.9	NUM
admet-2268	279	20	,	,	PUNCT
admet-2268	279	21	16.3	16.3	NUM
admet-2268	279	22	,	,	PUNCT
admet-2268	279	23	20.4	20.4	NUM
admet-2268	279	24	and	and	CCONJ
admet-2268	279	25	25.5	25.5	NUM
admet-2268	279	26	°	°	NOUN
admet-2268	280	1	[	[	X
admet-2268	280	2	39,40	39,40	NUM
admet-2268	280	3	]	]	PUNCT
admet-2268	280	4	.	.	PUNCT
admet-2268	281	1	diacerein	diacerein	PROPN
admet-2268	281	2	showed	show	VERB
admet-2268	281	3	sharp	sharp	ADJ
admet-2268	281	4	peaks	peak	NOUN
admet-2268	281	5	at	at	ADP
admet-2268	281	6	5.2	5.2	NUM
admet-2268	281	7	,	,	PUNCT
admet-2268	281	8	10.5	10.5	NUM
admet-2268	281	9	,	,	PUNCT
admet-2268	281	10	17.4	17.4	NUM
admet-2268	281	11	,	,	PUNCT
admet-2268	281	12	21.9	21.9	NUM
admet-2268	281	13	,	,	PUNCT
admet-2268	281	14	25.1	25.1	NUM
admet-2268	281	15	and	and	CCONJ
admet-2268	281	16	27.8	27.8	NUM
admet-2268	281	17	°	°	NOUN
admet-2268	281	18	,	,	PUNCT
admet-2268	281	19	exhibiting	exhibit	VERB
admet-2268	281	20	its	its	PRON
admet-2268	281	21	crystallinity	crystallinity	NOUN
admet-2268	281	22	.	.	PUNCT
admet-2268	282	1	a	a	DET
admet-2268	282	2	similar	similar	ADJ
admet-2268	282	3	diffraction	diffraction	NOUN
admet-2268	282	4	pattern	pattern	NOUN
admet-2268	282	5	of	of	ADP
admet-2268	282	6	diacerein	diacerein	ADJ
admet-2268	282	7	has	have	AUX
admet-2268	282	8	been	be	AUX
admet-2268	282	9	reported	report	VERB
admet-2268	282	10	earlier	early	ADV
admet-2268	282	11	[	[	X
admet-2268	282	12	50	50	NUM
admet-2268	282	13	]	]	PUNCT
admet-2268	282	14	.	.	PUNCT
admet-2268	283	1	peaks	peak	NOUN
admet-2268	283	2	at	at	ADP
admet-2268	283	3	5.4	5.4	NUM
admet-2268	283	4	,	,	PUNCT
admet-2268	283	5	10.3	10.3	NUM
admet-2268	283	6	,	,	PUNCT
admet-2268	283	7	12.4	12.4	NUM
admet-2268	283	8	,	,	PUNCT
admet-2268	283	9	17.39	17.39	NUM
admet-2268	283	10	and	and	CCONJ
admet-2268	283	11	27.25	27.25	NUM
admet-2268	283	12	°	°	NOUN
admet-2268	283	13	in	in	ADP
admet-2268	283	14	the	the	DET
admet-2268	283	15	diffractogram	diffractogram	NOUN
admet-2268	283	16	of	of	ADP
admet-2268	283	17	the	the	DET
admet-2268	283	18	berberine	berberine	NOUN
admet-2268	283	19	hcl	hcl	PROPN
admet-2268	283	20	and	and	CCONJ
admet-2268	283	21	diacerein	diacerein	ADJ
admet-2268	283	22	physical	physical	ADJ
admet-2268	283	23	mixture	mixture	NOUN
admet-2268	283	24	indicate	indicate	VERB
admet-2268	283	25	no	no	DET
admet-2268	283	26	change	change	NOUN
admet-2268	283	27	in	in	ADP
admet-2268	283	28	the	the	DET
admet-2268	283	29	physical	physical	ADJ
admet-2268	283	30	form	form	NOUN
admet-2268	283	31	of	of	ADP
admet-2268	283	32	the	the	DET
admet-2268	283	33	mixture	mixture	NOUN
admet-2268	283	34	.	.	PUNCT
admet-2268	284	1	a	a	DET
admet-2268	284	2	major	major	ADJ
admet-2268	284	3	broad	broad	ADJ
admet-2268	284	4	peak	peak	NOUN
admet-2268	284	5	of	of	ADP
admet-2268	284	6	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	284	7	and	and	CCONJ
admet-2268	284	8	a	a	DET
admet-2268	284	9	peak	peak	NOUN
admet-2268	284	10	of	of	ADP
admet-2268	284	11	sodium	sodium	NOUN
admet-2268	284	12	deoxycholate	deoxycholate	ADJ
admet-2268	284	13	were	be	AUX
admet-2268	284	14	recorded	record	VERB
admet-2268	284	15	at	at	ADP
admet-2268	284	16	21.02	21.02	NUM
admet-2268	284	17	and	and	CCONJ
admet-2268	284	18	15.43	15.43	NUM
admet-2268	284	19	°	°	NOUN
admet-2268	284	20	,	,	PUNCT
admet-2268	284	21	respectively	respectively	ADV
admet-2268	284	22	.	.	PUNCT
admet-2268	285	1	the	the	DET
admet-2268	285	2	optimized	optimize	VERB
admet-2268	285	3	formulation	formulation	NOUN
admet-2268	285	4	(	(	PUNCT
admet-2268	285	5	ddt-10	ddt-10	PROPN
admet-2268	285	6	)	)	PUNCT
admet-2268	285	7	exhibited	exhibit	VERB
admet-2268	285	8	peaks	peak	NOUN
admet-2268	285	9	at	at	ADP
admet-2268	285	10	5.56	5.56	NUM
admet-2268	285	11	,	,	PUNCT
admet-2268	285	12	10.88	10.88	NUM
admet-2268	285	13	,	,	PUNCT
admet-2268	285	14	13.99	13.99	NUM
admet-2268	285	15	,	,	PUNCT
admet-2268	285	16	15.92	15.92	NUM
admet-2268	285	17	,	,	PUNCT
admet-2268	285	18	17.7	17.7	NUM
admet-2268	285	19	and	and	CCONJ
admet-2268	285	20	28.23	28.23	NUM
admet-2268	285	21	°	°	NOUN
admet-2268	285	22	with	with	ADP
admet-2268	285	23	reduced	reduced	ADJ
admet-2268	285	24	intensity	intensity	NOUN
admet-2268	285	25	,	,	PUNCT
admet-2268	285	26	indicating	indicate	VERB
admet-2268	285	27	the	the	DET
admet-2268	285	28	partial	partial	ADJ
admet-2268	285	29	conversion	conversion	NOUN
admet-2268	285	30	of	of	ADP
admet-2268	285	31	drug	drug	NOUN
admet-2268	285	32	molecules	molecule	NOUN
admet-2268	285	33	into	into	ADP
admet-2268	285	34	the	the	DET
admet-2268	285	35	amorphous	amorphous	ADJ
admet-2268	285	36	phase	phase	NOUN
admet-2268	285	37	(	(	PUNCT
admet-2268	285	38	figure	figure	NOUN
admet-2268	285	39	7	7	NUM
admet-2268	285	40	)	)	PUNCT
admet-2268	285	41	.	.	PUNCT
admet-2268	286	1	admet	admet	PROPN
admet-2268	286	2	&	&	CCONJ
admet-2268	286	3	dmpk	dmpk	PROPN
admet-2268	286	4	12(3	12(3	PROPN
admet-2268	286	5	)	)	PUNCT
admet-2268	286	6	(	(	PUNCT
admet-2268	286	7	2024	2024	NUM
admet-2268	286	8	)	)	PUNCT
admet-2268	286	9	553	553	NUM
admet-2268	286	10	-	-	SYM
admet-2268	286	11	580	580	NUM
admet-2268	286	12	berberine	berberine	NOUN
admet-2268	286	13	hcl	hcl	PROPN
admet-2268	286	14	and	and	CCONJ
admet-2268	286	15	diacerein	diacerein	ADV
admet-2268	286	16	loaded	load	VERB
admet-2268	286	17	dual	dual	ADJ
admet-2268	286	18	delivery	delivery	NOUN
admet-2268	286	19	transferosomes	transferosome	NOUN
admet-2268	286	20	doi	doi	PROPN
admet-2268	286	21	:	:	PUNCT
admet-2268	286	22	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	286	23	569	569	NUM
admet-2268	286	24	2	2	NUM
admet-2268	286	25	/	/	SYM
admet-2268	287	1	°	°	NUM
admet-2268	287	2	2	2	NUM
admet-2268	287	3	/	/	SYM
admet-2268	288	1	°	°	NUM
admet-2268	288	2	2	2	NUM
admet-2268	288	3	/	/	SYM
admet-2268	289	1	°	°	NUM
admet-2268	289	2	2	2	NUM
admet-2268	289	3	/	/	SYM
admet-2268	290	1	°	°	NUM
admet-2268	290	2	2	2	NUM
admet-2268	290	3	/	/	SYM
admet-2268	291	1	°	°	NUM
admet-2268	291	2	2	2	NUM
admet-2268	292	1	/	/	SYM
admet-2268	292	2	°	°	NUM
admet-2268	292	3	figure	figure	NOUN
admet-2268	292	4	7	7	NUM
admet-2268	292	5	.	.	PUNCT
admet-2268	293	1	x	x	X
admet-2268	293	2	-	-	NOUN
admet-2268	293	3	ray	ray	NOUN
admet-2268	293	4	diffraction	diffraction	NOUN
admet-2268	293	5	spectrum	spectrum	NOUN
admet-2268	293	6	of	of	ADP
admet-2268	293	7	a	a	DET
admet-2268	293	8	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	293	9	,	,	PUNCT
admet-2268	293	10	b	b	PROPN
admet-2268	293	11	sodium	sodium	NOUN
admet-2268	293	12	deoxycholate	deoxycholate	VERB
admet-2268	293	13	,	,	PUNCT
admet-2268	293	14	c	c	PROPN
admet-2268	293	15	berberine	berberine	PROPN
admet-2268	293	16	hcl	hcl	PROPN
admet-2268	293	17	,	,	PUNCT
admet-2268	293	18	d	d	X
admet-2268	293	19	diacerein	diacerein	ADJ
admet-2268	293	20	,	,	PUNCT
admet-2268	293	21	e	e	PROPN
admet-2268	293	22	physical	physical	ADJ
admet-2268	293	23	mixture	mixture	NOUN
admet-2268	293	24	of	of	ADP
admet-2268	293	25	berberine	berberine	NOUN
admet-2268	293	26	hcl	hcl	PROPN
admet-2268	293	27	and	and	CCONJ
admet-2268	293	28	diacerein	diacerein	ADJ
admet-2268	293	29	and	and	CCONJ
admet-2268	293	30	f	f	PROPN
admet-2268	293	31	optimized	optimize	VERB
admet-2268	293	32	formulation	formulation	NOUN
admet-2268	293	33	(	(	PUNCT
admet-2268	293	34	formulation	formulation	NOUN
admet-2268	293	35	ddt-10	ddt-10	NOUN
admet-2268	293	36	)	)	PUNCT
admet-2268	293	37	.	.	PUNCT
admet-2268	294	1	thermogravimetric	thermogravimetric	ADJ
admet-2268	294	2	analysis	analysis	NOUN
admet-2268	294	3	thermogravimetric	thermogravimetric	ADJ
admet-2268	294	4	analysis	analysis	NOUN
admet-2268	294	5	was	be	AUX
admet-2268	294	6	used	use	VERB
admet-2268	294	7	to	to	PART
admet-2268	294	8	ascertain	ascertain	VERB
admet-2268	294	9	the	the	DET
admet-2268	294	10	temperature	temperature	NOUN
admet-2268	294	11	dependence	dependence	NOUN
admet-2268	294	12	of	of	ADP
admet-2268	294	13	weight	weight	NOUN
admet-2268	294	14	loss	loss	NOUN
admet-2268	294	15	(	(	PUNCT
admet-2268	294	16	figure	figure	NOUN
admet-2268	294	17	8)	8)	NUM
admet-2268	294	18	.	.	PUNCT
admet-2268	295	1	percentage	percentage	NOUN
admet-2268	295	2	weight	weight	NOUN
admet-2268	295	3	loss	loss	NOUN
admet-2268	295	4	is	be	AUX
admet-2268	295	5	represented	represent	VERB
admet-2268	295	6	as	as	ADP
admet-2268	295	7	delta	delta	PROPN
admet-2268	295	8	y.	y.	PROPN
admet-2268	295	9	pure	pure	PROPN
admet-2268	295	10	berberine	berberine	PROPN
admet-2268	295	11	hcl	hcl	PROPN
admet-2268	295	12	exhibited	exhibit	VERB
admet-2268	295	13	three	three	NUM
admet-2268	295	14	stages	stage	NOUN
admet-2268	295	15	of	of	ADP
admet-2268	295	16	weight	weight	NOUN
admet-2268	295	17	loss	loss	NOUN
admet-2268	295	18	:	:	PUNCT
admet-2268	295	19	near	near	ADP
admet-2268	295	20	100	100	NUM
admet-2268	295	21	,	,	PUNCT
admet-2268	295	22	180	180	NUM
admet-2268	295	23	and	and	CCONJ
admet-2268	295	24	above	above	ADP
admet-2268	295	25	280	280	NUM
admet-2268	295	26	°	°	NOUN
admet-2268	295	27	c	c	NOUN
admet-2268	295	28	.	.	PUNCT
admet-2268	296	1	this	this	DET
admet-2268	296	2	weight	weight	NOUN
admet-2268	296	3	loss	loss	NOUN
admet-2268	296	4	occurred	occur	VERB
admet-2268	296	5	due	due	ADP
admet-2268	296	6	to	to	ADP
admet-2268	296	7	the	the	DET
admet-2268	296	8	decomposition	decomposition	NOUN
admet-2268	296	9	of	of	ADP
admet-2268	296	10	the	the	DET
admet-2268	296	11	water	water	NOUN
admet-2268	296	12	[	[	X
admet-2268	296	13	51	51	NUM
admet-2268	296	14	]	]	PUNCT
admet-2268	296	15	.	.	PUNCT
admet-2268	297	1	pure	pure	ADJ
admet-2268	297	2	diacerein	diacerein	PROPN
admet-2268	297	3	exhibited	exhibit	VERB
admet-2268	297	4	weight	weight	NOUN
admet-2268	297	5	loss	loss	NOUN
admet-2268	297	6	above	above	ADP
admet-2268	297	7	250	250	NUM
admet-2268	297	8	°	°	ADP
admet-2268	297	9	c	c	NOUN
admet-2268	297	10	due	due	ADP
admet-2268	297	11	to	to	ADP
admet-2268	297	12	water	water	NOUN
admet-2268	297	13	decomposition	decomposition	NOUN
admet-2268	297	14	.	.	PUNCT
admet-2268	298	1	the	the	DET
admet-2268	298	2	physical	physical	ADJ
admet-2268	298	3	mixtures	mixture	NOUN
admet-2268	298	4	of	of	ADP
admet-2268	298	5	berberine	berberine	NOUN
admet-2268	298	6	hcl	hcl	PROPN
admet-2268	298	7	and	and	CCONJ
admet-2268	298	8	diacerein	diacerein	ADV
admet-2268	298	9	showed	show	VERB
admet-2268	298	10	no	no	DET
admet-2268	298	11	temperature	temperature	NOUN
admet-2268	298	12	change	change	NOUN
admet-2268	298	13	and	and	CCONJ
admet-2268	298	14	found	find	VERB
admet-2268	298	15	weight	weight	NOUN
admet-2268	298	16	loss	loss	NOUN
admet-2268	298	17	near	near	ADP
admet-2268	298	18	100	100	NUM
admet-2268	298	19	and	and	CCONJ
admet-2268	298	20	above	above	ADP
admet-2268	298	21	200	200	NUM
admet-2268	298	22	°	°	NOUN
admet-2268	298	23	c	c	NOUN
admet-2268	298	24	.	.	PUNCT
admet-2268	299	1	the	the	DET
admet-2268	299	2	major	major	ADJ
admet-2268	299	3	reason	reason	NOUN
admet-2268	299	4	for	for	ADP
admet-2268	299	5	weight	weight	NOUN
admet-2268	299	6	loss	loss	NOUN
admet-2268	299	7	is	be	AUX
admet-2268	299	8	due	due	ADJ
admet-2268	299	9	to	to	ADP
admet-2268	299	10	the	the	DET
admet-2268	299	11	slow	slow	ADJ
admet-2268	299	12	elimination	elimination	NOUN
admet-2268	299	13	of	of	ADP
admet-2268	299	14	the	the	DET
admet-2268	299	15	methoxy	methoxy	ADJ
admet-2268	299	16	group	group	NOUN
admet-2268	299	17	[	[	X
admet-2268	299	18	52	52	NUM
admet-2268	299	19	]	]	PUNCT
admet-2268	299	20	.	.	PUNCT
admet-2268	300	1	the	the	DET
admet-2268	300	2	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	300	3	did	do	AUX
admet-2268	300	4	not	not	PART
admet-2268	300	5	depict	depict	VERB
admet-2268	300	6	any	any	DET
admet-2268	300	7	peak	peak	NOUN
admet-2268	300	8	.	.	PUNCT
admet-2268	301	1	sodium	sodium	PROPN
admet-2268	301	2	deoxycholate	deoxycholate	PROPN
admet-2268	301	3	exhibited	exhibit	VERB
admet-2268	301	4	a	a	DET
admet-2268	301	5	peak	peak	NOUN
admet-2268	301	6	near	near	ADP
admet-2268	301	7	350	350	NUM
admet-2268	301	8	°	°	NOUN
admet-2268	301	9	c	c	NOUN
admet-2268	301	10	.	.	PUNCT
admet-2268	302	1	formulation	formulation	NOUN
admet-2268	302	2	ddt-10	ddt-10	PRON
admet-2268	302	3	exhibited	exhibit	VERB
admet-2268	302	4	a	a	DET
admet-2268	302	5	peak	peak	NOUN
admet-2268	302	6	near	near	ADP
admet-2268	302	7	150	150	NUM
admet-2268	302	8	°	°	NOUN
admet-2268	302	9	c	c	NOUN
admet-2268	302	10	,	,	PUNCT
admet-2268	302	11	which	which	PRON
admet-2268	302	12	signifies	signify	VERB
admet-2268	302	13	weight	weight	NOUN
admet-2268	302	14	loss	loss	NOUN
admet-2268	302	15	due	due	ADP
admet-2268	302	16	to	to	ADP
admet-2268	302	17	the	the	DET
admet-2268	302	18	entrapment	entrapment	NOUN
admet-2268	302	19	of	of	ADP
admet-2268	302	20	the	the	DET
admet-2268	302	21	drug	drug	NOUN
admet-2268	302	22	molecules	molecule	NOUN
admet-2268	302	23	in	in	ADP
admet-2268	302	24	the	the	DET
admet-2268	302	25	lipid	lipid	NOUN
admet-2268	302	26	bilayers	bilayer	NOUN
admet-2268	302	27	and	and	CCONJ
admet-2268	302	28	water	water	NOUN
admet-2268	302	29	loss	loss	NOUN
admet-2268	302	30	[	[	X
admet-2268	302	31	20	20	NUM
admet-2268	302	32	]	]	PUNCT
admet-2268	302	33	.	.	PUNCT
admet-2268	303	1	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	PROPN
admet-2268	303	2	s.	s.	PROPN
admet-2268	303	3	singh	singh	PROPN
admet-2268	303	4	and	and	CCONJ
admet-2268	303	5	r.	r.	PROPN
admet-2268	303	6	awasthi	awasthi	PROPN
admet-2268	303	7	admet	admet	PROPN
admet-2268	303	8	&	&	CCONJ
admet-2268	303	9	dmpk	dmpk	PROPN
admet-2268	303	10	12(3	12(3	PROPN
admet-2268	303	11	)	)	PUNCT
admet-2268	303	12	(	(	PUNCT
admet-2268	303	13	2024	2024	NUM
admet-2268	303	14	)	)	PUNCT
admet-2268	303	15	553	553	NUM
admet-2268	303	16	-	-	SYM
admet-2268	303	17	580	580	NUM
admet-2268	303	18	570	570	NUM
admet-2268	303	19	figure	figure	NOUN
admet-2268	303	20	8	8	NUM
admet-2268	303	21	.	.	PUNCT
admet-2268	303	22	results	result	NOUN
admet-2268	303	23	of	of	ADP
admet-2268	303	24	thermogravimetric	thermogravimetric	ADJ
admet-2268	303	25	analyses	analysis	NOUN
admet-2268	303	26	of	of	ADP
admet-2268	303	27	a	a	DET
admet-2268	303	28	berberine	berberine	NOUN
admet-2268	303	29	hcl	hcl	PROPN
admet-2268	303	30	,	,	PUNCT
admet-2268	303	31	b	b	X
admet-2268	303	32	diacerein	diacerein	ADJ
admet-2268	303	33	,	,	PUNCT
admet-2268	303	34	c	c	PROPN
admet-2268	303	35	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	303	36	,	,	PUNCT
admet-2268	303	37	d	d	PROPN
admet-2268	303	38	sodium	sodium	NOUN
admet-2268	303	39	deoxycholate	deoxycholate	VERB
admet-2268	303	40	,	,	PUNCT
admet-2268	303	41	e	e	X
admet-2268	303	42	physical	physical	ADJ
admet-2268	303	43	mixture	mixture	NOUN
admet-2268	303	44	of	of	ADP
admet-2268	303	45	diacerein	diacerein	ADJ
admet-2268	303	46	and	and	CCONJ
admet-2268	303	47	berberine	berberine	PROPN
admet-2268	303	48	hcl	hcl	PROPN
admet-2268	303	49	and	and	CCONJ
admet-2268	303	50	f	f	PROPN
admet-2268	303	51	optimized	optimize	VERB
admet-2268	303	52	formulation	formulation	NOUN
admet-2268	303	53	(	(	PUNCT
admet-2268	303	54	formulation	formulation	NOUN
admet-2268	303	55	ddt-10	ddt-10	VERB
admet-2268	303	56	)	)	PUNCT
admet-2268	303	57	.	.	PUNCT
admet-2268	304	1	the	the	DET
admet-2268	304	2	curve	curve	NOUN
admet-2268	304	3	representing	represent	VERB
admet-2268	304	4	delta	delta	NOUN
admet-2268	304	5	y	y	PROPN
admet-2268	304	6	indicates	indicate	VERB
admet-2268	304	7	residual	residual	ADJ
admet-2268	304	8	weight	weight	NOUN
admet-2268	304	9	loss	loss	NOUN
admet-2268	304	10	.	.	PUNCT
admet-2268	305	1	morphological	morphological	ADJ
admet-2268	305	2	characterization	characterization	NOUN
admet-2268	305	3	tem	tem	NOUN
admet-2268	305	4	images	image	NOUN
admet-2268	305	5	revealed	reveal	VERB
admet-2268	305	6	the	the	DET
admet-2268	305	7	spherical	spherical	ADJ
admet-2268	305	8	shape	shape	NOUN
admet-2268	305	9	of	of	ADP
admet-2268	305	10	the	the	DET
admet-2268	305	11	transferosomes	transferosome	NOUN
admet-2268	305	12	(	(	PUNCT
admet-2268	305	13	formulation	formulation	NOUN
admet-2268	305	14	ddt-10	ddt-10	VERB
admet-2268	305	15	)	)	PUNCT
admet-2268	305	16	without	without	ADP
admet-2268	305	17	aggregation	aggregation	NOUN
admet-2268	305	18	of	of	ADP
admet-2268	305	19	particles	particle	NOUN
admet-2268	305	20	(	(	PUNCT
admet-2268	305	21	figure	figure	NOUN
admet-2268	305	22	9a	9a	NOUN
admet-2268	305	23	)	)	PUNCT
admet-2268	305	24	.	.	PUNCT
admet-2268	306	1	the	the	DET
admet-2268	306	2	vesicle	vesicle	NOUN
admet-2268	306	3	size	size	NOUN
admet-2268	306	4	in	in	ADP
admet-2268	306	5	tem	tem	PROPN
admet-2268	306	6	analysis	analysis	NOUN
admet-2268	306	7	was	be	AUX
admet-2268	306	8	found	find	VERB
admet-2268	306	9	to	to	PART
admet-2268	306	10	be	be	AUX
admet-2268	306	11	near	near	ADP
admet-2268	306	12	the	the	DET
admet-2268	306	13	dls	dls	PROPN
admet-2268	306	14	result	result	NOUN
admet-2268	306	15	and	and	CCONJ
admet-2268	306	16	can	can	AUX
admet-2268	306	17	be	be	AUX
admet-2268	306	18	acceptable	acceptable	ADJ
admet-2268	306	19	for	for	ADP
admet-2268	306	20	topical	topical	ADJ
admet-2268	306	21	administration	administration	NOUN
admet-2268	306	22	.	.	PUNCT
admet-2268	307	1	however	however	ADV
admet-2268	307	2	,	,	PUNCT
admet-2268	307	3	there	there	PRON
admet-2268	307	4	is	be	VERB
admet-2268	307	5	no	no	DET
admet-2268	307	6	fundamental	fundamental	ADJ
admet-2268	307	7	linkage	linkage	NOUN
admet-2268	307	8	between	between	ADP
admet-2268	307	9	the	the	DET
admet-2268	307	10	tem	tem	PROPN
admet-2268	307	11	and	and	CCONJ
admet-2268	307	12	dls	dls	PROPN
admet-2268	307	13	results	result	NOUN
admet-2268	307	14	because	because	SCONJ
admet-2268	307	15	dls	dls	PROPN
admet-2268	307	16	works	work	VERB
admet-2268	307	17	on	on	ADP
admet-2268	307	18	the	the	DET
admet-2268	307	19	brownian	brownian	ADJ
admet-2268	307	20	motion	motion	NOUN
admet-2268	307	21	principle	principle	NOUN
admet-2268	307	22	,	,	PUNCT
admet-2268	307	23	and	and	CCONJ
admet-2268	307	24	in	in	ADP
admet-2268	307	25	tem	tem	PROPN
admet-2268	307	26	,	,	PUNCT
admet-2268	307	27	image	image	NOUN
admet-2268	307	28	formation	formation	NOUN
admet-2268	307	29	occurs	occur	VERB
admet-2268	307	30	due	due	ADJ
admet-2268	307	31	to	to	ADP
admet-2268	307	32	the	the	DET
admet-2268	307	33	passing	passing	NOUN
admet-2268	307	34	of	of	ADP
admet-2268	307	35	the	the	DET
admet-2268	307	36	electron	electron	NOUN
admet-2268	307	37	flux	flux	NOUN
admet-2268	307	38	through	through	ADP
admet-2268	307	39	the	the	DET
admet-2268	307	40	sample	sample	NOUN
admet-2268	307	41	.	.	PUNCT
admet-2268	308	1	moreover	moreover	ADV
admet-2268	308	2	,	,	PUNCT
admet-2268	308	3	tem	tem	PROPN
admet-2268	308	4	is	be	AUX
admet-2268	308	5	a	a	DET
admet-2268	308	6	number	number	NOUN
admet-2268	308	7	-	-	PUNCT
admet-2268	308	8	based	base	VERB
admet-2268	308	9	technique	technique	NOUN
admet-2268	308	10	,	,	PUNCT
admet-2268	308	11	while	while	SCONJ
admet-2268	308	12	dls	dls	PROPN
admet-2268	308	13	is	be	AUX
admet-2268	308	14	an	an	DET
admet-2268	308	15	intensity	intensity	NOUN
admet-2268	308	16	-	-	PUNCT
admet-2268	308	17	based	base	VERB
admet-2268	308	18	technique	technique	NOUN
admet-2268	308	19	.	.	PUNCT
admet-2268	309	1	in	in	ADP
admet-2268	309	2	dls	dls	PROPN
admet-2268	309	3	,	,	PUNCT
admet-2268	309	4	particles	particle	NOUN
admet-2268	309	5	show	show	VERB
admet-2268	309	6	larger	large	ADJ
admet-2268	309	7	diameters	diameter	NOUN
admet-2268	309	8	because	because	SCONJ
admet-2268	309	9	of	of	ADP
admet-2268	309	10	the	the	DET
admet-2268	309	11	development	development	NOUN
admet-2268	309	12	of	of	ADP
admet-2268	309	13	hydrating	hydrate	VERB
admet-2268	309	14	layers	layer	NOUN
admet-2268	309	15	around	around	ADP
admet-2268	309	16	the	the	DET
admet-2268	309	17	particles	particle	NOUN
admet-2268	309	18	,	,	PUNCT
admet-2268	309	19	and	and	CCONJ
admet-2268	309	20	it	it	PRON
admet-2268	309	21	calculates	calculate	VERB
admet-2268	309	22	hydrodynamic	hydrodynamic	ADJ
admet-2268	309	23	diameter	diameter	NOUN
admet-2268	309	24	,	,	PUNCT
admet-2268	309	25	while	while	SCONJ
admet-2268	309	26	tem	tem	PROPN
admet-2268	309	27	discloses	disclose	VERB
admet-2268	309	28	the	the	DET
admet-2268	309	29	projected	project	VERB
admet-2268	309	30	surface	surface	NOUN
admet-2268	309	31	area	area	NOUN
admet-2268	309	32	of	of	ADP
admet-2268	309	33	particles	particle	NOUN
admet-2268	309	34	.	.	PUNCT
admet-2268	310	1	selected	select	VERB
admet-2268	310	2	area	area	NOUN
admet-2268	310	3	electron	electron	NOUN
admet-2268	310	4	diffraction	diffraction	NOUN
admet-2268	310	5	(	(	PUNCT
admet-2268	310	6	saed	saed	NOUN
admet-2268	310	7	)	)	PUNCT
admet-2268	310	8	analysis	analysis	NOUN
admet-2268	310	9	reveals	reveal	VERB
admet-2268	310	10	the	the	DET
admet-2268	310	11	crystallinity	crystallinity	NOUN
admet-2268	310	12	of	of	ADP
admet-2268	310	13	loaded	load	VERB
admet-2268	310	14	molecules	molecule	NOUN
admet-2268	310	15	.	.	PUNCT
admet-2268	311	1	the	the	DET
admet-2268	311	2	appearance	appearance	NOUN
admet-2268	311	3	of	of	ADP
admet-2268	311	4	the	the	DET
admet-2268	311	5	diffused	diffuse	VERB
admet-2268	311	6	rings	ring	NOUN
admet-2268	311	7	signifies	signify	VERB
admet-2268	311	8	the	the	DET
admet-2268	311	9	loaded	loaded	ADJ
admet-2268	311	10	crystallinity	crystallinity	NOUN
admet-2268	311	11	of	of	ADP
admet-2268	311	12	the	the	DET
admet-2268	311	13	molecule	molecule	NOUN
admet-2268	311	14	.	.	PUNCT
admet-2268	312	1	the	the	DET
admet-2268	312	2	optimized	optimize	VERB
admet-2268	312	3	formulation	formulation	NOUN
admet-2268	312	4	(	(	PUNCT
admet-2268	312	5	formulation	formulation	NOUN
admet-2268	312	6	ddt-10	ddt-10	NOUN
admet-2268	312	7	)	)	PUNCT
admet-2268	312	8	did	do	AUX
admet-2268	312	9	not	not	PART
admet-2268	312	10	show	show	VERB
admet-2268	312	11	any	any	DET
admet-2268	312	12	diffused	diffused	ADJ
admet-2268	312	13	layers	layer	NOUN
admet-2268	312	14	in	in	ADP
admet-2268	312	15	the	the	DET
admet-2268	312	16	saed	saed	NOUN
admet-2268	312	17	pattern	pattern	NOUN
admet-2268	312	18	,	,	PUNCT
admet-2268	312	19	which	which	PRON
admet-2268	312	20	confirmed	confirm	VERB
admet-2268	312	21	that	that	SCONJ
admet-2268	312	22	drug	drug	NOUN
admet-2268	312	23	molecules	molecule	NOUN
admet-2268	312	24	are	be	AUX
admet-2268	312	25	not	not	PART
admet-2268	312	26	in	in	ADP
admet-2268	312	27	crystalline	crystalline	NOUN
admet-2268	312	28	form	form	NOUN
admet-2268	312	29	(	(	PUNCT
admet-2268	312	30	at	at	ADP
admet-2268	312	31	least	least	ADJ
admet-2268	312	32	not	not	PART
admet-2268	312	33	at	at	ADP
admet-2268	312	34	a	a	DET
admet-2268	312	35	larger	large	ADJ
admet-2268	312	36	scale	scale	NOUN
admet-2268	312	37	)	)	PUNCT
admet-2268	312	38	(	(	PUNCT
admet-2268	312	39	figure	figure	NOUN
admet-2268	312	40	9b	9b	NUM
admet-2268	312	41	)	)	PUNCT
admet-2268	312	42	.	.	PUNCT
admet-2268	313	1	surface	surface	NOUN
admet-2268	313	2	roughness	roughness	NOUN
admet-2268	313	3	has	have	VERB
admet-2268	313	4	a	a	DET
admet-2268	313	5	great	great	ADJ
admet-2268	313	6	impact	impact	NOUN
admet-2268	313	7	on	on	ADP
admet-2268	313	8	cellular	cellular	ADJ
admet-2268	313	9	uptake	uptake	NOUN
admet-2268	313	10	.	.	PUNCT
admet-2268	314	1	afm	afm	PROPN
admet-2268	314	2	analysis	analysis	NOUN
admet-2268	314	3	is	be	AUX
admet-2268	314	4	used	use	VERB
admet-2268	314	5	to	to	PART
admet-2268	314	6	analyse	analyse	VERB
admet-2268	314	7	surface	surface	NOUN
admet-2268	314	8	topography	topography	NOUN
admet-2268	314	9	information	information	NOUN
admet-2268	314	10	from	from	ADP
admet-2268	314	11	2d	2d	NUM
admet-2268	314	12	and	and	CCONJ
admet-2268	314	13	3d	3d	NUM
admet-2268	314	14	views	view	NOUN
admet-2268	314	15	[	[	X
admet-2268	314	16	18,53	18,53	NUM
admet-2268	314	17	]	]	PUNCT
admet-2268	314	18	.	.	PUNCT
admet-2268	315	1	the	the	DET
admet-2268	315	2	optimized	optimize	VERB
admet-2268	315	3	formulation	formulation	NOUN
admet-2268	315	4	(	(	PUNCT
admet-2268	315	5	formulation	formulation	NOUN
admet-2268	315	6	ddt-10	ddt-10	NOUN
admet-2268	315	7	)	)	PUNCT
admet-2268	315	8	had	have	VERB
admet-2268	315	9	ra	ra	PROPN
admet-2268	315	10	(	(	PUNCT
admet-2268	315	11	average	average	ADJ
admet-2268	315	12	roughness	roughness	NOUN
admet-2268	315	13	)	)	PUNCT
admet-2268	315	14	values	value	NOUN
admet-2268	315	15	of	of	ADP
admet-2268	315	16	5.43	5.43	NUM
admet-2268	315	17	nm	nm	NOUN
admet-2268	315	18	and	and	CCONJ
admet-2268	315	19	rq	rq	X
admet-2268	315	20	(	(	PUNCT
admet-2268	315	21	root	root	NOUN
admet-2268	315	22	mean	mean	ADJ
admet-2268	315	23	square	square	ADJ
admet-2268	315	24	)	)	PUNCT
admet-2268	315	25	values	value	NOUN
admet-2268	315	26	of	of	ADP
admet-2268	315	27	6.58	6.58	NUM
admet-2268	315	28	nm	nm	NOUN
admet-2268	315	29	(	(	PUNCT
admet-2268	315	30	figure	figure	NOUN
admet-2268	315	31	9c	9c	NUM
admet-2268	315	32	)	)	PUNCT
admet-2268	315	33	.	.	PUNCT
admet-2268	316	1	admet	admet	PROPN
admet-2268	316	2	&	&	CCONJ
admet-2268	316	3	dmpk	dmpk	PROPN
admet-2268	316	4	12(3	12(3	PROPN
admet-2268	316	5	)	)	PUNCT
admet-2268	316	6	(	(	PUNCT
admet-2268	316	7	2024	2024	NUM
admet-2268	316	8	)	)	PUNCT
admet-2268	316	9	553	553	NUM
admet-2268	316	10	-	-	SYM
admet-2268	316	11	580	580	NUM
admet-2268	316	12	berberine	berberine	NOUN
admet-2268	316	13	hcl	hcl	PROPN
admet-2268	316	14	and	and	CCONJ
admet-2268	316	15	diacerein	diacerein	ADV
admet-2268	316	16	loaded	load	VERB
admet-2268	316	17	dual	dual	ADJ
admet-2268	316	18	delivery	delivery	NOUN
admet-2268	316	19	transferosomes	transferosome	NOUN
admet-2268	316	20	doi	doi	PROPN
admet-2268	316	21	:	:	PUNCT
admet-2268	316	22	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	316	23	571	571	NUM
admet-2268	316	24	figure	figure	NOUN
admet-2268	316	25	9	9	NUM
admet-2268	316	26	.	.	PUNCT
admet-2268	316	27	results	result	NOUN
admet-2268	316	28	of	of	ADP
admet-2268	316	29	berberine	berberine	NOUN
admet-2268	316	30	and	and	CCONJ
admet-2268	316	31	diacerein	diacerein	ADV
admet-2268	316	32	-	-	PUNCT
admet-2268	316	33	loaded	load	VERB
admet-2268	316	34	optimized	optimize	VERB
admet-2268	316	35	transferosomes	transferosome	NOUN
admet-2268	316	36	(	(	PUNCT
admet-2268	316	37	formulation	formulation	NOUN
admet-2268	316	38	ddt-10	ddt-10	PROPN
admet-2268	316	39	):	):	PUNCT
admet-2268	316	40	a	a	DET
admet-2268	316	41	tem	tem	PROPN
admet-2268	316	42	image	image	NOUN
admet-2268	316	43	,	,	PUNCT
admet-2268	316	44	b	b	NOUN
admet-2268	316	45	selected	select	VERB
admet-2268	316	46	area	area	NOUN
admet-2268	316	47	electron	electron	NOUN
admet-2268	316	48	diffraction	diffraction	NOUN
admet-2268	316	49	(	(	PUNCT
admet-2268	316	50	saed	saed	NOUN
admet-2268	316	51	)	)	PUNCT
admet-2268	316	52	image	image	NOUN
admet-2268	316	53	and	and	CCONJ
admet-2268	316	54	c	c	PROPN
admet-2268	316	55	3d	3d	PROPN
admet-2268	316	56	afm	afm	PROPN
admet-2268	316	57	image	image	NOUN
admet-2268	316	58	.	.	PUNCT
admet-2268	317	1	deformability	deformability	NOUN
admet-2268	317	2	edge	edge	NOUN
admet-2268	317	3	activator	activator	NOUN
admet-2268	317	4	is	be	AUX
admet-2268	317	5	responsible	responsible	ADJ
admet-2268	317	6	for	for	ADP
admet-2268	317	7	transferosome	transferosome	ADJ
admet-2268	317	8	deformability	deformability	NOUN
admet-2268	317	9	,	,	PUNCT
admet-2268	317	10	which	which	PRON
admet-2268	317	11	permits	permit	VERB
admet-2268	317	12	them	they	PRON
admet-2268	317	13	to	to	PART
admet-2268	317	14	infiltrate	infiltrate	VERB
admet-2268	317	15	the	the	DET
admet-2268	317	16	stratum	stratum	NOUN
admet-2268	317	17	corneum	corneum	NOUN
admet-2268	317	18	due	due	ADP
admet-2268	317	19	to	to	ADP
admet-2268	317	20	their	their	PRON
admet-2268	317	21	squeezing	squeeze	VERB
admet-2268	317	22	and	and	CCONJ
admet-2268	317	23	deforming	deform	VERB
admet-2268	317	24	characteristics	characteristic	NOUN
admet-2268	317	25	.	.	PUNCT
admet-2268	318	1	the	the	DET
admet-2268	318	2	charge	charge	NOUN
admet-2268	318	3	on	on	ADP
admet-2268	318	4	the	the	DET
admet-2268	318	5	edge	edge	NOUN
admet-2268	318	6	activator	activator	NOUN
admet-2268	318	7	influences	influence	VERB
admet-2268	318	8	transferosome	transferosome	ADJ
admet-2268	318	9	characteristics	characteristic	NOUN
admet-2268	318	10	.	.	PUNCT
admet-2268	319	1	the	the	DET
admet-2268	319	2	results	result	NOUN
admet-2268	319	3	showed	show	VERB
admet-2268	319	4	that	that	SCONJ
admet-2268	319	5	the	the	DET
admet-2268	319	6	deformability	deformability	NOUN
admet-2268	319	7	of	of	ADP
admet-2268	319	8	the	the	DET
admet-2268	319	9	prepared	prepare	VERB
admet-2268	319	10	transferosomes	transferosome	NOUN
admet-2268	319	11	ranged	range	VERB
admet-2268	319	12	between	between	ADP
admet-2268	319	13	7.43±0.04	7.43±0.04	NOUN
admet-2268	319	14	to	to	ADP
admet-2268	319	15	14.51±0.12	14.51±0.12	NUM
admet-2268	319	16	%	%	NOUN
admet-2268	319	17	(	(	PUNCT
admet-2268	319	18	table	table	NOUN
admet-2268	319	19	2	2	NUM
admet-2268	319	20	)	)	PUNCT
admet-2268	319	21	.	.	PUNCT
admet-2268	320	1	the	the	DET
admet-2268	320	2	deformability	deformability	NOUN
admet-2268	320	3	of	of	ADP
admet-2268	320	4	optimized	optimize	VERB
admet-2268	320	5	formulation	formulation	NOUN
admet-2268	320	6	(	(	PUNCT
admet-2268	320	7	formulation	formulation	NOUN
admet-2268	320	8	ddt-10	ddt-10	NOUN
admet-2268	320	9	)	)	PUNCT
admet-2268	320	10	was	be	AUX
admet-2268	320	11	12.44±0.39	12.44±0.39	NUM
admet-2268	320	12	%	%	NOUN
admet-2268	320	13	.	.	PUNCT
admet-2268	321	1	this	this	PRON
admet-2268	321	2	signifies	signify	VERB
admet-2268	321	3	that	that	SCONJ
admet-2268	321	4	the	the	DET
admet-2268	321	5	amount	amount	NOUN
admet-2268	321	6	of	of	ADP
admet-2268	321	7	sodium	sodium	NOUN
admet-2268	321	8	deoxycholate	deoxycholate	NOUN
admet-2268	321	9	has	have	VERB
admet-2268	321	10	an	an	DET
admet-2268	321	11	effective	effective	ADJ
admet-2268	321	12	impression	impression	NOUN
admet-2268	321	13	on	on	ADP
admet-2268	321	14	the	the	DET
admet-2268	321	15	lipid	lipid	NOUN
admet-2268	321	16	bilayers	bilayer	NOUN
admet-2268	321	17	,	,	PUNCT
admet-2268	321	18	serves	serve	VERB
admet-2268	321	19	flexibility	flexibility	NOUN
admet-2268	321	20	in	in	ADP
admet-2268	321	21	transferosomal	transferosomal	ADJ
admet-2268	321	22	structure	structure	NOUN
admet-2268	321	23	without	without	ADP
admet-2268	321	24	any	any	DET
admet-2268	321	25	rupturing	rupturing	NOUN
admet-2268	321	26	,	,	PUNCT
admet-2268	321	27	and	and	CCONJ
admet-2268	321	28	provides	provide	VERB
admet-2268	321	29	the	the	DET
admet-2268	321	30	potential	potential	NOUN
admet-2268	321	31	to	to	PART
admet-2268	321	32	squeeze	squeeze	VERB
admet-2268	321	33	when	when	SCONJ
admet-2268	321	34	applied	apply	VERB
admet-2268	321	35	topically	topically	ADV
admet-2268	321	36	[	[	X
admet-2268	321	37	54	54	NUM
admet-2268	321	38	]	]	PUNCT
admet-2268	321	39	.	.	PUNCT
admet-2268	322	1	antioxidant	antioxidant	ADJ
admet-2268	322	2	activity	activity	NOUN
admet-2268	322	3	oxidative	oxidative	ADJ
admet-2268	322	4	stress	stress	NOUN
admet-2268	322	5	occurs	occur	VERB
admet-2268	322	6	when	when	SCONJ
admet-2268	322	7	there	there	PRON
admet-2268	322	8	is	be	VERB
admet-2268	322	9	an	an	DET
admet-2268	322	10	imbalance	imbalance	NOUN
admet-2268	322	11	between	between	ADP
admet-2268	322	12	the	the	DET
admet-2268	322	13	levels	level	NOUN
admet-2268	322	14	of	of	ADP
admet-2268	322	15	oxidants	oxidant	NOUN
admet-2268	322	16	and	and	CCONJ
admet-2268	322	17	antioxidants	antioxidant	NOUN
admet-2268	322	18	in	in	ADP
admet-2268	322	19	the	the	DET
admet-2268	322	20	body	body	NOUN
admet-2268	322	21	,	,	PUNCT
admet-2268	322	22	which	which	PRON
admet-2268	322	23	in	in	ADP
admet-2268	322	24	turn	turn	NOUN
admet-2268	322	25	contributes	contribute	VERB
admet-2268	322	26	to	to	ADP
admet-2268	322	27	the	the	DET
admet-2268	322	28	formation	formation	NOUN
admet-2268	322	29	of	of	ADP
admet-2268	322	30	reactive	reactive	ADJ
admet-2268	322	31	oxygen	oxygen	NOUN
admet-2268	322	32	species	specie	NOUN
admet-2268	322	33	(	(	PUNCT
admet-2268	322	34	ros	ros	PROPN
admet-2268	322	35	)	)	PUNCT
admet-2268	322	36	.	.	PUNCT
admet-2268	323	1	oxidative	oxidative	ADJ
admet-2268	323	2	stress	stress	NOUN
admet-2268	323	3	,	,	PUNCT
admet-2268	323	4	caused	cause	VERB
admet-2268	323	5	by	by	ADP
admet-2268	323	6	ros	ros	PROPN
admet-2268	323	7	,	,	PUNCT
admet-2268	323	8	has	have	VERB
admet-2268	323	9	a	a	DET
admet-2268	323	10	notable	notable	ADJ
admet-2268	323	11	impact	impact	NOUN
admet-2268	323	12	on	on	ADP
admet-2268	323	13	apoptosis	apoptosis	NOUN
admet-2268	323	14	,	,	PUNCT
admet-2268	323	15	autophagy	autophagy	NOUN
admet-2268	323	16	,	,	PUNCT
admet-2268	323	17	and	and	CCONJ
admet-2268	323	18	regeneration	regeneration	NOUN
admet-2268	323	19	processes	process	NOUN
admet-2268	323	20	and	and	CCONJ
admet-2268	323	21	contributes	contribute	VERB
admet-2268	323	22	to	to	ADP
admet-2268	323	23	the	the	DET
admet-2268	323	24	development	development	NOUN
admet-2268	323	25	of	of	ADP
admet-2268	323	26	psoriasis	psoriasis	NOUN
admet-2268	323	27	[	[	X
admet-2268	323	28	55	55	NUM
admet-2268	323	29	]	]	PUNCT
admet-2268	323	30	.	.	PUNCT
admet-2268	324	1	both	both	DET
admet-2268	324	2	berberine	berberine	PROPN
admet-2268	324	3	hcl	hcl	PROPN
admet-2268	324	4	and	and	CCONJ
admet-2268	324	5	diacerein	diacerein	ADV
admet-2268	324	6	possess	possess	VERB
admet-2268	324	7	the	the	DET
admet-2268	324	8	ability	ability	NOUN
admet-2268	324	9	to	to	PART
admet-2268	324	10	remove	remove	VERB
admet-2268	324	11	ros	ros	PROPN
admet-2268	324	12	and	and	CCONJ
admet-2268	324	13	demonstrate	demonstrate	VERB
admet-2268	324	14	antioxidant	antioxidant	ADJ
admet-2268	324	15	properties	property	NOUN
admet-2268	324	16	[	[	X
admet-2268	324	17	56,57	56,57	NOUN
admet-2268	324	18	]	]	X
admet-2268	324	19	.	.	PUNCT
admet-2268	325	1	it	it	PRON
admet-2268	325	2	has	have	AUX
admet-2268	325	3	been	be	AUX
admet-2268	325	4	reported	report	VERB
admet-2268	325	5	that	that	SCONJ
admet-2268	325	6	these	these	DET
admet-2268	325	7	molecules	molecule	NOUN
admet-2268	325	8	can	can	AUX
admet-2268	325	9	suppress	suppress	VERB
admet-2268	325	10	the	the	DET
admet-2268	325	11	activity	activity	NOUN
admet-2268	325	12	ros	ro	NOUN
admet-2268	325	13	in	in	ADP
admet-2268	325	14	a	a	DET
admet-2268	325	15	concentration	concentration	NOUN
admet-2268	325	16	-	-	PUNCT
admet-2268	325	17	dependent	dependent	ADJ
admet-2268	325	18	manner	manner	NOUN
admet-2268	325	19	.	.	PUNCT
admet-2268	326	1	due	due	ADP
admet-2268	326	2	to	to	ADP
admet-2268	326	3	their	their	PRON
admet-2268	326	4	high	high	ADJ
admet-2268	326	5	phenolic	phenolic	PROPN
admet-2268	326	6	group	group	NOUN
admet-2268	326	7	content	content	NOUN
admet-2268	326	8	,	,	PUNCT
admet-2268	326	9	berberine	berberine	NOUN
admet-2268	326	10	and	and	CCONJ
admet-2268	326	11	diacerein	diacerein	ADV
admet-2268	326	12	can	can	AUX
admet-2268	326	13	donate	donate	VERB
admet-2268	326	14	electrons	electron	NOUN
admet-2268	326	15	and	and	CCONJ
admet-2268	326	16	improve	improve	VERB
admet-2268	326	17	ros	ros	PROPN
admet-2268	326	18	scavenging	scavenge	VERB
admet-2268	326	19	[	[	X
admet-2268	326	20	58	58	NUM
admet-2268	326	21	]	]	PUNCT
admet-2268	326	22	.	.	PUNCT
admet-2268	327	1	berberine	berberine	PROPN
admet-2268	327	2	hcl	hcl	PROPN
admet-2268	327	3	can	can	AUX
admet-2268	327	4	increase	increase	VERB
admet-2268	327	5	the	the	DET
admet-2268	327	6	levels	level	NOUN
admet-2268	327	7	of	of	ADP
admet-2268	327	8	endogenous	endogenous	ADJ
admet-2268	327	9	antioxidants	antioxidant	NOUN
admet-2268	327	10	like	like	ADP
admet-2268	327	11	catalase	catalase	NOUN
admet-2268	327	12	,	,	PUNCT
admet-2268	327	13	superoxide	superoxide	NOUN
admet-2268	327	14	dismutase	dismutase	NOUN
admet-2268	327	15	,	,	PUNCT
admet-2268	327	16	and	and	CCONJ
admet-2268	327	17	glutathione	glutathione	NOUN
admet-2268	327	18	peroxidase	peroxidase	NOUN
admet-2268	327	19	.	.	PUNCT
admet-2268	328	1	it	it	PRON
admet-2268	328	2	also	also	ADV
admet-2268	328	3	promotes	promote	VERB
admet-2268	328	4	the	the	DET
admet-2268	328	5	downregulation	downregulation	NOUN
admet-2268	328	6	of	of	ADP
admet-2268	328	7	oxidative	oxidative	ADJ
admet-2268	328	8	stress	stress	NOUN
admet-2268	328	9	markers	marker	NOUN
admet-2268	328	10	such	such	ADJ
admet-2268	328	11	as	as	ADP
admet-2268	328	12	glutathione	glutathione	NOUN
admet-2268	328	13	and	and	CCONJ
admet-2268	328	14	malondialdehyde	malondialdehyde	NOUN
admet-2268	329	1	[	[	X
admet-2268	329	2	59	59	NUM
admet-2268	329	3	]	]	PUNCT
admet-2268	329	4	.	.	PUNCT
admet-2268	330	1	the	the	DET
admet-2268	330	2	current	current	ADJ
admet-2268	330	3	investigation	investigation	NOUN
admet-2268	330	4	involved	involve	VERB
admet-2268	330	5	the	the	DET
admet-2268	330	6	utilization	utilization	NOUN
admet-2268	330	7	of	of	ADP
admet-2268	330	8	ascorbic	ascorbic	NOUN
admet-2268	330	9	acid	acid	NOUN
admet-2268	330	10	as	as	ADP
admet-2268	330	11	a	a	DET
admet-2268	330	12	reference	reference	NOUN
admet-2268	330	13	compound	compound	NOUN
admet-2268	330	14	,	,	PUNCT
admet-2268	330	15	which	which	PRON
admet-2268	330	16	demonstrated	demonstrate	VERB
admet-2268	330	17	an	an	DET
admet-2268	330	18	ic50	ic50	PROPN
admet-2268	330	19	value	value	NOUN
admet-2268	330	20	of	of	ADP
admet-2268	330	21	14.2±0.1	14.2±0.1	NUM
admet-2268	330	22	μg	μg	PROPN
admet-2268	330	23	ml-1	ml-1	X
admet-2268	330	24	.	.	PUNCT
admet-2268	331	1	additionally	additionally	ADV
admet-2268	331	2	,	,	PUNCT
admet-2268	331	3	the	the	DET
admet-2268	331	4	optimized	optimize	VERB
admet-2268	331	5	formulation	formulation	NOUN
admet-2268	331	6	exhibited	exhibit	VERB
admet-2268	331	7	an	an	DET
admet-2268	331	8	ic50	ic50	PROPN
admet-2268	331	9	value	value	NOUN
admet-2268	331	10	of	of	ADP
admet-2268	331	11	36.42	36.42	NUM
admet-2268	331	12	μg	μg	PROPN
admet-2268	331	13	ml-1	ml-1	X
admet-2268	331	14	.	.	PUNCT
admet-2268	332	1	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	PROPN
admet-2268	332	2	s.	s.	PROPN
admet-2268	332	3	singh	singh	PROPN
admet-2268	332	4	and	and	CCONJ
admet-2268	332	5	r.	r.	PROPN
admet-2268	332	6	awasthi	awasthi	PROPN
admet-2268	332	7	admet	admet	PROPN
admet-2268	332	8	&	&	CCONJ
admet-2268	332	9	dmpk	dmpk	PROPN
admet-2268	332	10	12(3	12(3	PROPN
admet-2268	332	11	)	)	PUNCT
admet-2268	332	12	(	(	PUNCT
admet-2268	332	13	2024	2024	NUM
admet-2268	332	14	)	)	PUNCT
admet-2268	332	15	553	553	NUM
admet-2268	332	16	-	-	SYM
admet-2268	332	17	580	580	NUM
admet-2268	332	18	572	572	NUM
admet-2268	332	19	in	in	ADP
admet-2268	332	20	vitro	vitro	X
admet-2268	332	21	release	release	NOUN
admet-2268	332	22	study	study	NOUN
admet-2268	332	23	and	and	CCONJ
admet-2268	332	24	release	release	VERB
admet-2268	332	25	kinetics	kinetic	NOUN
admet-2268	332	26	a	a	DET
admet-2268	332	27	study	study	NOUN
admet-2268	332	28	was	be	AUX
admet-2268	332	29	performed	perform	VERB
admet-2268	332	30	to	to	PART
admet-2268	332	31	examine	examine	VERB
admet-2268	332	32	the	the	DET
admet-2268	332	33	extended	extend	VERB
admet-2268	332	34	-	-	PUNCT
admet-2268	332	35	release	release	NOUN
admet-2268	332	36	of	of	ADP
admet-2268	332	37	berberine	berberine	NOUN
admet-2268	332	38	hcl	hcl	PROPN
admet-2268	332	39	and	and	CCONJ
admet-2268	332	40	diacerein	diacerein	VERB
admet-2268	332	41	from	from	ADP
admet-2268	332	42	the	the	DET
admet-2268	332	43	optimized	optimize	VERB
admet-2268	332	44	transferosomes	transferosome	NOUN
admet-2268	332	45	in	in	ADP
admet-2268	332	46	alkaline	alkaline	NOUN
admet-2268	332	47	media	medium	NOUN
admet-2268	332	48	(	(	PUNCT
admet-2268	332	49	ph	ph	NOUN
admet-2268	332	50	7.4	7.4	NUM
admet-2268	332	51	)	)	PUNCT
admet-2268	332	52	.	.	PUNCT
admet-2268	333	1	the	the	DET
admet-2268	333	2	study	study	NOUN
admet-2268	333	3	aimed	aim	VERB
admet-2268	333	4	to	to	PART
admet-2268	333	5	get	get	VERB
admet-2268	333	6	a	a	DET
admet-2268	333	7	better	well	ADJ
admet-2268	333	8	understanding	understanding	NOUN
admet-2268	333	9	of	of	ADP
admet-2268	333	10	the	the	DET
admet-2268	333	11	mechanism	mechanism	NOUN
admet-2268	333	12	of	of	ADP
admet-2268	333	13	drug	drug	NOUN
admet-2268	333	14	release	release	NOUN
admet-2268	333	15	.	.	PUNCT
admet-2268	334	1	the	the	DET
admet-2268	334	2	in	in	ADV
admet-2268	334	3	vitro	vitro	X
admet-2268	334	4	dissolution	dissolution	NOUN
admet-2268	334	5	study	study	NOUN
admet-2268	334	6	was	be	AUX
admet-2268	334	7	conducted	conduct	VERB
admet-2268	334	8	for	for	ADP
admet-2268	334	9	24	24	NUM
admet-2268	334	10	h	h	NOUN
admet-2268	334	11	utilizing	utilize	VERB
admet-2268	334	12	a	a	DET
admet-2268	334	13	dialysis	dialysis	NOUN
admet-2268	334	14	bag	bag	NOUN
admet-2268	334	15	method	method	NOUN
admet-2268	334	16	.	.	PUNCT
admet-2268	335	1	after	after	ADP
admet-2268	335	2	18	18	NUM
admet-2268	335	3	h	h	NOUN
admet-2268	335	4	,	,	PUNCT
admet-2268	335	5	the	the	DET
admet-2268	335	6	release	release	NOUN
admet-2268	335	7	of	of	ADP
admet-2268	335	8	berberine	berberine	NOUN
admet-2268	335	9	hcl	hcl	PROPN
admet-2268	335	10	and	and	CCONJ
admet-2268	335	11	diacerein	diacerein	VERB
admet-2268	335	12	from	from	ADP
admet-2268	335	13	the	the	DET
admet-2268	335	14	optimized	optimize	VERB
admet-2268	335	15	formulation	formulation	NOUN
admet-2268	335	16	was	be	AUX
admet-2268	335	17	found	find	VERB
admet-2268	335	18	to	to	PART
admet-2268	335	19	be	be	AUX
admet-2268	335	20	82.09±0.81	82.09±0.81	NUM
admet-2268	335	21	and	and	CCONJ
admet-2268	335	22	85.02±3.81	85.02±3.81	NUM
admet-2268	335	23	%	%	NOUN
admet-2268	335	24	,	,	PUNCT
admet-2268	335	25	respectively	respectively	ADV
admet-2268	335	26	.	.	PUNCT
admet-2268	336	1	the	the	DET
admet-2268	336	2	results	result	NOUN
admet-2268	336	3	demonstrated	demonstrate	VERB
admet-2268	336	4	that	that	SCONJ
admet-2268	336	5	the	the	DET
admet-2268	336	6	optimized	optimize	VERB
admet-2268	336	7	transferosomes	transferosome	NOUN
admet-2268	336	8	exhibited	exhibit	VERB
admet-2268	336	9	a	a	DET
admet-2268	336	10	sustained	sustained	ADJ
admet-2268	336	11	release	release	NOUN
admet-2268	336	12	of	of	ADP
admet-2268	336	13	berberine	berberine	NOUN
admet-2268	336	14	hcl	hcl	PROPN
admet-2268	336	15	and	and	CCONJ
admet-2268	336	16	diacerein	diacerein	ADJ
admet-2268	336	17	,	,	PUNCT
admet-2268	336	18	potentially	potentially	ADV
admet-2268	336	19	enhancing	enhance	VERB
admet-2268	336	20	the	the	DET
admet-2268	336	21	therapeutic	therapeutic	ADJ
admet-2268	336	22	efficacy	efficacy	NOUN
admet-2268	336	23	of	of	ADP
admet-2268	336	24	both	both	DET
admet-2268	336	25	drugs	drug	NOUN
admet-2268	336	26	.	.	PUNCT
admet-2268	337	1	the	the	DET
admet-2268	337	2	dissolution	dissolution	NOUN
admet-2268	337	3	study	study	NOUN
admet-2268	337	4	was	be	AUX
admet-2268	337	5	terminated	terminate	VERB
admet-2268	337	6	after	after	ADP
admet-2268	337	7	24	24	NUM
admet-2268	337	8	h	h	NOUN
admet-2268	337	9	when	when	SCONJ
admet-2268	337	10	90.546±0.21	90.546±0.21	NUM
admet-2268	337	11	%	%	NOUN
admet-2268	337	12	of	of	ADP
admet-2268	337	13	berberine	berberine	NOUN
admet-2268	337	14	hcl	hcl	PROPN
admet-2268	337	15	and	and	CCONJ
admet-2268	337	16	98.730±3.21	98.730±3.21	NUM
admet-2268	337	17	%	%	NOUN
admet-2268	337	18	of	of	ADP
admet-2268	337	19	diacerein	diacerein	ADJ
admet-2268	337	20	were	be	AUX
admet-2268	337	21	released	release	VERB
admet-2268	337	22	(	(	PUNCT
admet-2268	337	23	figure	figure	NOUN
admet-2268	337	24	10	10	NUM
admet-2268	337	25	)	)	PUNCT
admet-2268	337	26	.	.	PUNCT
admet-2268	338	1	time	time	NOUN
admet-2268	338	2	,	,	PUNCT
admet-2268	338	3	min	min	NOUN
admet-2268	338	4	figure	figure	NOUN
admet-2268	338	5	10	10	NUM
admet-2268	338	6	.	.	PUNCT
admet-2268	339	1	dissolution	dissolution	PROPN
admet-2268	339	2	profile	profile	NOUN
admet-2268	339	3	of	of	ADP
admet-2268	339	4	berberine	berberine	NOUN
admet-2268	339	5	hcl	hcl	PROPN
admet-2268	339	6	(	(	PUNCT
admet-2268	339	7	empty	empty	ADJ
admet-2268	339	8	triangles	triangle	NOUN
admet-2268	339	9	)	)	PUNCT
admet-2268	339	10	and	and	CCONJ
admet-2268	339	11	diacerein	diacerein	ADJ
admet-2268	339	12	(	(	PUNCT
admet-2268	339	13	filled	fill	VERB
admet-2268	339	14	circles	circle	NOUN
admet-2268	339	15	)	)	PUNCT
admet-2268	339	16	from	from	ADP
admet-2268	339	17	the	the	DET
admet-2268	339	18	optimized	optimize	VERB
admet-2268	339	19	transferosomes	transferosome	NOUN
admet-2268	339	20	(	(	PUNCT
admet-2268	339	21	formulation	formulation	NOUN
admet-2268	339	22	ddt-10	ddt-10	VERB
admet-2268	339	23	)	)	PUNCT
admet-2268	339	24	in	in	ADP
admet-2268	339	25	pbs	pbs	PROPN
admet-2268	339	26	ph	ph	VERB
admet-2268	339	27	7.4	7.4	NUM
admet-2268	339	28	(	(	PUNCT
admet-2268	339	29	data	datum	NOUN
admet-2268	339	30	presents	present	VERB
admet-2268	339	31	mean±sd	mean±sd	PROPN
admet-2268	339	32	,	,	PUNCT
admet-2268	339	33	n	n	NOUN
admet-2268	339	34	=	=	SYM
admet-2268	339	35	3	3	NUM
admet-2268	339	36	)	)	PUNCT
admet-2268	339	37	.	.	PUNCT
admet-2268	340	1	the	the	DET
admet-2268	340	2	most	most	ADV
admet-2268	340	3	appropriate	appropriate	ADJ
admet-2268	340	4	kinetic	kinetic	ADJ
admet-2268	340	5	model	model	NOUN
admet-2268	340	6	was	be	AUX
admet-2268	340	7	selected	select	VERB
admet-2268	340	8	based	base	VERB
admet-2268	340	9	on	on	ADP
admet-2268	340	10	its	its	PRON
admet-2268	340	11	goodness	goodness	NOUN
admet-2268	340	12	of	of	ADP
admet-2268	340	13	fit	fit	PROPN
admet-2268	340	14	,	,	PUNCT
admet-2268	340	15	determined	determine	VERB
admet-2268	340	16	by	by	ADP
admet-2268	340	17	the	the	DET
admet-2268	340	18	highest	high	ADJ
admet-2268	340	19	r2	r2	NOUN
admet-2268	340	20	value	value	NOUN
admet-2268	340	21	.	.	PUNCT
admet-2268	341	1	in	in	ADP
admet-2268	341	2	the	the	DET
admet-2268	341	3	present	present	ADJ
admet-2268	341	4	study	study	NOUN
admet-2268	341	5	,	,	PUNCT
admet-2268	341	6	the	the	DET
admet-2268	341	7	release	release	NOUN
admet-2268	341	8	characteristics	characteristic	NOUN
admet-2268	341	9	of	of	ADP
admet-2268	341	10	berberine	berberine	NOUN
admet-2268	341	11	hcl	hcl	PROPN
admet-2268	341	12	and	and	CCONJ
admet-2268	341	13	diacerein	diacerein	VERB
admet-2268	341	14	from	from	ADP
admet-2268	341	15	the	the	DET
admet-2268	341	16	optimized	optimize	VERB
admet-2268	341	17	transferosomes	transferosome	NOUN
admet-2268	341	18	were	be	AUX
admet-2268	341	19	best	well	ADV
admet-2268	341	20	explained	explain	VERB
admet-2268	341	21	by	by	ADP
admet-2268	341	22	zero	zero	NUM
admet-2268	341	23	-	-	PUNCT
admet-2268	341	24	order	order	NOUN
admet-2268	341	25	kinetics	kinetic	NOUN
admet-2268	341	26	with	with	ADP
admet-2268	341	27	r2	r2	PROPN
admet-2268	341	28	values	value	NOUN
admet-2268	341	29	of	of	ADP
admet-2268	341	30	0.9850	0.9850	NUM
admet-2268	341	31	and	and	CCONJ
admet-2268	341	32	0.9901	0.9901	NUM
admet-2268	341	33	,	,	PUNCT
admet-2268	341	34	respectively	respectively	ADV
admet-2268	341	35	.	.	PUNCT
admet-2268	342	1	the	the	DET
admet-2268	342	2	linearity	linearity	NOUN
admet-2268	342	3	and	and	CCONJ
admet-2268	342	4	correlation	correlation	NOUN
admet-2268	342	5	coefficient	coefficient	NOUN
admet-2268	342	6	values	value	NOUN
admet-2268	342	7	of	of	ADP
admet-2268	342	8	higuchi	higuchi	PROPN
admet-2268	342	9	's	's	PART
admet-2268	342	10	plot	plot	NOUN
admet-2268	342	11	suggest	suggest	VERB
admet-2268	342	12	that	that	SCONJ
admet-2268	342	13	the	the	DET
admet-2268	342	14	release	release	NOUN
admet-2268	342	15	profiles	profile	NOUN
admet-2268	342	16	are	be	AUX
admet-2268	342	17	regulated	regulate	VERB
admet-2268	342	18	by	by	ADP
admet-2268	342	19	diffusion	diffusion	NOUN
admet-2268	342	20	.	.	PUNCT
admet-2268	343	1	peppas	peppas	PROPN
admet-2268	343	2	’	'	PUNCT
admet-2268	343	3	model	model	NOUN
admet-2268	343	4	showed	show	VERB
admet-2268	343	5	good	good	ADJ
admet-2268	343	6	linearity	linearity	NOUN
admet-2268	343	7	for	for	ADP
admet-2268	343	8	berberine	berberine	NOUN
admet-2268	343	9	hcl	hcl	PROPN
admet-2268	343	10	(	(	PUNCT
admet-2268	343	11	r2	r2	PROPN
admet-2268	343	12	=	=	SYM
admet-2268	343	13	0.9834	0.9834	NUM
admet-2268	343	14	)	)	PUNCT
admet-2268	343	15	and	and	CCONJ
admet-2268	343	16	diacerein	diacerein	ADJ
admet-2268	343	17	(	(	PUNCT
admet-2268	343	18	r2	r2	PROPN
admet-2268	343	19	=	=	SYM
admet-2268	343	20	0.9893	0.9893	NUM
admet-2268	343	21	)	)	PUNCT
admet-2268	343	22	from	from	ADP
admet-2268	343	23	the	the	DET
admet-2268	343	24	optimized	optimize	VERB
admet-2268	343	25	transferosomes	transferosome	NOUN
admet-2268	343	26	in	in	ADP
admet-2268	343	27	alkaline	alkaline	NOUN
admet-2268	343	28	media	medium	NOUN
admet-2268	343	29	(	(	PUNCT
admet-2268	343	30	ph	ph	NOUN
admet-2268	343	31	7.4	7.4	NUM
admet-2268	343	32	)	)	PUNCT
admet-2268	343	33	.	.	PUNCT
admet-2268	344	1	according	accord	VERB
admet-2268	344	2	to	to	ADP
admet-2268	344	3	peppas	peppas	PROPN
admet-2268	344	4	'	'	PART
admet-2268	344	5	theory	theory	NOUN
admet-2268	344	6	,	,	PUNCT
admet-2268	344	7	fickian	fickian	ADJ
admet-2268	344	8	diffusion	diffusion	NOUN
admet-2268	344	9	controls	control	VERB
admet-2268	344	10	the	the	DET
admet-2268	344	11	drug	drug	NOUN
admet-2268	344	12	's	's	PART
admet-2268	344	13	release	release	NOUN
admet-2268	344	14	when	when	SCONJ
admet-2268	344	15	the	the	DET
admet-2268	344	16	value	value	NOUN
admet-2268	344	17	of	of	ADP
admet-2268	344	18	n	n	NUM
admet-2268	344	19	is	be	AUX
admet-2268	344	20	0.43	0.43	NUM
admet-2268	344	21	.	.	PUNCT
admet-2268	345	1	when	when	SCONJ
admet-2268	345	2	the	the	DET
admet-2268	345	3	value	value	NOUN
admet-2268	345	4	of	of	ADP
admet-2268	345	5	n	n	NUM
admet-2268	345	6	is	be	AUX
admet-2268	345	7	between	between	ADP
admet-2268	345	8	0.43	0.43	NUM
admet-2268	345	9	and	and	CCONJ
admet-2268	345	10	0.85	0.85	NUM
admet-2268	345	11	,	,	PUNCT
admet-2268	345	12	the	the	DET
admet-2268	345	13	drug	drug	NOUN
admet-2268	345	14	release	release	NOUN
admet-2268	345	15	follows	follow	VERB
admet-2268	345	16	anomalous	anomalous	ADJ
admet-2268	345	17	(	(	PUNCT
admet-2268	345	18	non	non	ADJ
admet-2268	345	19	-	-	ADJ
admet-2268	345	20	fickian	fickian	ADJ
admet-2268	345	21	)	)	PUNCT
admet-2268	345	22	diffusion	diffusion	NOUN
admet-2268	345	23	.	.	PUNCT
admet-2268	346	1	when	when	SCONJ
admet-2268	346	2	the	the	DET
admet-2268	346	3	value	value	NOUN
admet-2268	346	4	of	of	ADP
admet-2268	346	5	n	n	NUM
admet-2268	346	6	is	be	AUX
admet-2268	346	7	0.85	0.85	NUM
admet-2268	346	8	,	,	PUNCT
admet-2268	346	9	the	the	DET
admet-2268	346	10	drug	drug	NOUN
admet-2268	346	11	release	release	NOUN
admet-2268	346	12	is	be	AUX
admet-2268	346	13	characterized	characterize	VERB
admet-2268	346	14	by	by	ADP
admet-2268	346	15	case	case	NOUN
admet-2268	346	16	ii	ii	NOUN
admet-2268	346	17	transport	transport	NOUN
admet-2268	346	18	,	,	PUNCT
admet-2268	346	19	which	which	PRON
admet-2268	346	20	implies	imply	VERB
admet-2268	346	21	the	the	DET
admet-2268	346	22	expansion	expansion	NOUN
admet-2268	346	23	of	of	ADP
admet-2268	346	24	the	the	DET
admet-2268	346	25	polymer	polymer	NOUN
admet-2268	346	26	matrix	matrix	NOUN
admet-2268	346	27	.	.	PUNCT
admet-2268	347	1	finally	finally	ADV
admet-2268	347	2	,	,	PUNCT
admet-2268	347	3	when	when	SCONJ
admet-2268	347	4	the	the	DET
admet-2268	347	5	value	value	NOUN
admet-2268	347	6	of	of	ADP
admet-2268	347	7	n	n	NUM
admet-2268	347	8	is	be	AUX
admet-2268	347	9	greater	great	ADJ
admet-2268	347	10	than	than	ADP
admet-2268	347	11	0.85	0.85	NUM
admet-2268	347	12	,	,	PUNCT
admet-2268	347	13	the	the	DET
admet-2268	347	14	drug	drug	NOUN
admet-2268	347	15	release	release	NOUN
admet-2268	347	16	is	be	AUX
admet-2268	347	17	described	describe	VERB
admet-2268	347	18	as	as	ADP
admet-2268	347	19	super	super	ADJ
admet-2268	347	20	-	-	ADJ
admet-2268	347	21	case	case	ADJ
admet-2268	347	22	ii	ii	NOUN
admet-2268	347	23	transport	transport	NOUN
admet-2268	347	24	.	.	PUNCT
admet-2268	348	1	in	in	ADP
admet-2268	348	2	the	the	DET
admet-2268	348	3	present	present	ADJ
admet-2268	348	4	study	study	NOUN
admet-2268	348	5	,	,	PUNCT
admet-2268	348	6	best	well	ADV
admet-2268	348	7	fitting	fitting	ADJ
admet-2268	348	8	was	be	AUX
admet-2268	348	9	obtained	obtain	VERB
admet-2268	348	10	with	with	ADP
admet-2268	348	11	n	n	ADP
admet-2268	348	12	values	value	NOUN
admet-2268	348	13	of	of	ADP
admet-2268	348	14	0.43	0.43	NUM
admet-2268	348	15	 	 	SPACE
admet-2268	348	16	<	<	NOUN
admet-2268	348	17	 	 	SPACE
admet-2268	348	18	n	n	CCONJ
admet-2268	348	19	 	 	SPACE
admet-2268	348	20	<	<	X
admet-2268	348	21	 	 	SPACE
admet-2268	348	22	0.85	0.85	NUM
admet-2268	348	23	for	for	ADP
admet-2268	348	24	berberine	berberine	NOUN
admet-2268	348	25	hcl	hcl	PROPN
admet-2268	348	26	(	(	PUNCT
admet-2268	348	27	n	n	NOUN
admet-2268	348	28	=	=	SYM
admet-2268	348	29	0.6987	0.6987	NUM
admet-2268	348	30	)	)	PUNCT
admet-2268	348	31	and	and	CCONJ
admet-2268	348	32	diacerein	diacerein	ADJ
admet-2268	348	33	(	(	PUNCT
admet-2268	348	34	n	n	PROPN
admet-2268	348	35	=	=	SYM
admet-2268	348	36	0.8010	0.8010	NUM
admet-2268	348	37	)	)	PUNCT
admet-2268	348	38	,	,	PUNCT
admet-2268	348	39	which	which	PRON
admet-2268	348	40	indicates	indicate	VERB
admet-2268	348	41	anomalous	anomalous	ADJ
admet-2268	348	42	(	(	PUNCT
admet-2268	348	43	non	non	ADJ
admet-2268	348	44	-	-	ADJ
admet-2268	348	45	fickian	fickian	ADJ
admet-2268	348	46	)	)	PUNCT
admet-2268	348	47	diffusion	diffusion	NOUN
admet-2268	348	48	of	of	ADP
admet-2268	348	49	loaded	load	VERB
admet-2268	348	50	drugs	drug	NOUN
admet-2268	348	51	from	from	ADP
admet-2268	348	52	the	the	DET
admet-2268	348	53	developed	develop	VERB
admet-2268	348	54	transferosomes	transferosome	NOUN
admet-2268	348	55	(	(	PUNCT
admet-2268	348	56	table	table	NOUN
admet-2268	348	57	6	6	NUM
admet-2268	348	58	)	)	PUNCT
admet-2268	348	59	.	.	PUNCT
admet-2268	349	1	table	table	NOUN
admet-2268	349	2	6	6	NUM
admet-2268	349	3	:	:	PUNCT
admet-2268	349	4	results	result	NOUN
admet-2268	349	5	of	of	ADP
admet-2268	349	6	kinetic	kinetic	ADJ
admet-2268	349	7	modeling	modeling	NOUN
admet-2268	349	8	of	of	ADP
admet-2268	349	9	berberine	berberine	NOUN
admet-2268	349	10	hcl	hcl	PROPN
admet-2268	349	11	and	and	CCONJ
admet-2268	349	12	diacerein	diacerein	ADJ
admet-2268	349	13	release	release	VERB
admet-2268	349	14	data	datum	NOUN
admet-2268	349	15	from	from	ADP
admet-2268	349	16	optimized	optimize	VERB
admet-2268	349	17	transferosomes	transferosome	NOUN
admet-2268	349	18	(	(	PUNCT
admet-2268	349	19	formulation	formulation	NOUN
admet-2268	349	20	ddt-10	ddt-10	VERB
admet-2268	349	21	)	)	PUNCT
admet-2268	349	22	in	in	ADP
admet-2268	349	23	alkaline	alkaline	NOUN
admet-2268	349	24	media	medium	NOUN
admet-2268	349	25	(	(	PUNCT
admet-2268	349	26	ph	ph	NOUN
admet-2268	349	27	7.4	7.4	NUM
admet-2268	349	28	)	)	PUNCT
admet-2268	349	29	.	.	PUNCT
admet-2268	350	1	kinetic	kinetic	ADJ
admet-2268	350	2	model	model	NOUN
admet-2268	350	3	berberine	berberine	PROPN
admet-2268	350	4	hcl	hcl	PROPN
admet-2268	350	5	diacerein	diacerein	ADJ
admet-2268	350	6	coefficient	coefficient	NOUN
admet-2268	350	7	of	of	ADP
admet-2268	350	8	correlation	correlation	NOUN
admet-2268	350	9	(	(	PUNCT
admet-2268	350	10	r2	r2	NOUN
admet-2268	350	11	)	)	PUNCT
admet-2268	350	12	rate	rate	NOUN
admet-2268	350	13	constant	constant	ADJ
admet-2268	350	14	(	(	PUNCT
admet-2268	350	15	k	k	NOUN
admet-2268	350	16	)	)	PUNCT
admet-2268	350	17	coefficient	coefficient	NOUN
admet-2268	350	18	of	of	ADP
admet-2268	350	19	correlation	correlation	NOUN
admet-2268	350	20	(	(	PUNCT
admet-2268	350	21	r2	r2	NOUN
admet-2268	350	22	)	)	PUNCT
admet-2268	350	23	rate	rate	NOUN
admet-2268	350	24	constant	constant	ADJ
admet-2268	350	25	(	(	PUNCT
admet-2268	350	26	k	k	NOUN
admet-2268	350	27	)	)	PUNCT
admet-2268	350	28	zero	zero	NUM
admet-2268	350	29	order	order	VERB
admet-2268	350	30	0.9850	0.9850	NUM
admet-2268	350	31	0.0710	0.0710	NUM
admet-2268	350	32	0.9901	0.9901	NUM
admet-2268	350	33	0.0767	0.0767	NUM
admet-2268	350	34	t	t	NOUN
admet-2268	350	35	-	-	PUNCT
admet-2268	350	36	test	test	NOUN
admet-2268	350	37	20.606	20.606	NUM
admet-2268	350	38	(	(	PUNCT
admet-2268	350	39	passes	pass	NOUN
admet-2268	350	40	)	)	PUNCT
admet-2268	350	41	25.378	25.378	NUM
admet-2268	350	42	(	(	PUNCT
admet-2268	350	43	passes	pass	NOUN
admet-2268	350	44	)	)	PUNCT
admet-2268	350	45	first	first	ADJ
admet-2268	350	46	order	order	NOUN
admet-2268	350	47	0.9591	0.9591	NUM
admet-2268	350	48	-0.0014	-0.0014	NOUN
admet-2268	350	49	0.8831	0.8831	NUM
admet-2268	350	50	-0.0019	-0.0019	NOUN
admet-2268	350	51	t	t	NOUN
admet-2268	350	52	-	-	PUNCT
admet-2268	350	53	test	test	NOUN
admet-2268	350	54	12.224	12.224	NUM
admet-2268	350	55	(	(	PUNCT
admet-2268	350	56	passes	pass	NOUN
admet-2268	350	57	)	)	PUNCT
admet-2268	350	58	6.786	6.786	NUM
admet-2268	350	59	(	(	PUNCT
admet-2268	350	60	passes	pass	NOUN
admet-2268	350	61	)	)	PUNCT
admet-2268	350	62	higuchi	higuchi	PROPN
admet-2268	350	63	’s	’s	PART
admet-2268	350	64	model	model	NOUN
admet-2268	350	65	0.9407	0.9407	NUM
admet-2268	350	66	2.0391	2.0391	NUM
admet-2268	350	67	0.9461	0.9461	NUM
admet-2268	350	68	2.2013	2.2013	NUM
admet-2268	350	69	t	t	NOUN
admet-2268	350	70	-	-	PUNCT
admet-2268	350	71	test	test	NOUN
admet-2268	350	72	10.002	10.002	NUM
admet-2268	350	73	(	(	PUNCT
admet-2268	350	74	passes	pass	NOUN
admet-2268	350	75	)	)	PUNCT
admet-2268	350	76	10.530	10.530	NUM
admet-2268	350	77	(	(	PUNCT
admet-2268	350	78	passes	pass	NOUN
admet-2268	350	79	)	)	PUNCT
admet-2268	350	80	korsmeyer	korsmeyer	NOUN
admet-2268	350	81	-	-	PUNCT
admet-2268	350	82	peppas	peppas	PROPN
admet-2268	350	83	’	'	PUNCT
admet-2268	350	84	model	model	NOUN
admet-2268	350	85	*	*	PROPN
admet-2268	350	86	0.9834	0.9834	NUM
admet-2268	350	87	0.5171	0.5171	NUM
admet-2268	350	88	0.9893	0.9893	NUM
admet-2268	350	89	0.2890	0.2890	NUM
admet-2268	350	90	t	t	NOUN
admet-2268	350	91	-	-	PUNCT
admet-2268	350	92	test	test	NOUN
admet-2268	350	93	19.559	19.559	NUM
admet-2268	350	94	(	(	PUNCT
admet-2268	350	95	passes	pass	NOUN
admet-2268	350	96	)	)	PUNCT
admet-2268	350	97	24.400	24.400	NUM
admet-2268	350	98	(	(	PUNCT
admet-2268	350	99	passes	pass	NOUN
admet-2268	350	100	)	)	PUNCT
admet-2268	350	101	hixson	hixson	PROPN
admet-2268	350	102	crowell	crowell	PROPN
admet-2268	350	103	model	model	NOUN
admet-2268	350	104	0.9825	0.9825	NUM
admet-2268	350	105	-0.0004	-0.0004	NOUN
admet-2268	350	106	0.9688	0.9688	NUM
admet-2268	350	107	-0.0004	-0.0004	NOUN
admet-2268	350	108	t	t	NOUN
admet-2268	350	109	-	-	PUNCT
admet-2268	350	110	test	test	NOUN
admet-2268	350	111	19.034	19.034	NUM
admet-2268	350	112	(	(	PUNCT
admet-2268	350	113	passes	pass	NOUN
admet-2268	350	114	)	)	PUNCT
admet-2268	350	115	14.094	14.094	NUM
admet-2268	350	116	(	(	PUNCT
admet-2268	350	117	passes	pass	NOUN
admet-2268	350	118	)	)	PUNCT
admet-2268	350	119	*	*	PUNCT
admet-2268	350	120	n	n	PRON
admet-2268	350	121	value	value	NOUN
admet-2268	350	122	of	of	ADP
admet-2268	350	123	berberine	berberine	NOUN
admet-2268	350	124	hcl	hcl	PROPN
admet-2268	350	125	and	and	CCONJ
admet-2268	350	126	diacerein	diacerein	ADV
admet-2268	350	127	are	be	AUX
admet-2268	350	128	0.6987	0.6987	NUM
admet-2268	350	129	and	and	CCONJ
admet-2268	350	130	0.8010	0.8010	NUM
admet-2268	350	131	,	,	PUNCT
admet-2268	350	132	respectively	respectively	ADV
admet-2268	350	133	c	c	NOUN
admet-2268	350	134	u	u	NOUN
admet-2268	350	135	m	m	VERB
admet-2268	350	136	u	u	VERB
admet-2268	350	137	la	la	X
admet-2268	350	138	ti	ti	X
admet-2268	350	139	ve	ve	PROPN
admet-2268	350	140	d	d	PROPN
admet-2268	350	141	ru	ru	PROPN
admet-2268	350	142	g	g	PROPN
admet-2268	350	143	re	re	ADP
admet-2268	350	144	le	le	NOUN
admet-2268	350	145	as	as	ADP
admet-2268	350	146	e	e	PROPN
admet-2268	350	147	,	,	PUNCT
admet-2268	350	148	%	%	INTJ
admet-2268	350	149	admet	admet	PROPN
admet-2268	350	150	&	&	CCONJ
admet-2268	350	151	dmpk	dmpk	PROPN
admet-2268	350	152	12(3	12(3	PROPN
admet-2268	350	153	)	)	PUNCT
admet-2268	350	154	(	(	PUNCT
admet-2268	350	155	2024	2024	NUM
admet-2268	350	156	)	)	PUNCT
admet-2268	350	157	553	553	NUM
admet-2268	350	158	-	-	SYM
admet-2268	350	159	580	580	NUM
admet-2268	350	160	berberine	berberine	NOUN
admet-2268	350	161	hcl	hcl	PROPN
admet-2268	350	162	and	and	CCONJ
admet-2268	350	163	diacerein	diacerein	ADV
admet-2268	350	164	loaded	load	VERB
admet-2268	351	1	dual	dual	ADJ
admet-2268	351	2	delivery	delivery	NOUN
admet-2268	351	3	transferosomes	transferosome	NOUN
admet-2268	351	4	doi	doi	PROPN
admet-2268	351	5	:	:	PUNCT
admet-2268	351	6	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	351	7	573	573	NUM
admet-2268	351	8	ex	ex	X
admet-2268	351	9	vivo	vivo	ADJ
admet-2268	351	10	permeation	permeation	NOUN
admet-2268	351	11	studies	study	NOUN
admet-2268	351	12	the	the	DET
admet-2268	351	13	ex	ex	ADJ
admet-2268	351	14	-	-	ADJ
admet-2268	351	15	vivo	vivo	ADJ
admet-2268	351	16	permeation	permeation	NOUN
admet-2268	351	17	studies	study	NOUN
admet-2268	351	18	were	be	AUX
admet-2268	351	19	performed	perform	VERB
admet-2268	351	20	using	use	VERB
admet-2268	351	21	pig	pig	NOUN
admet-2268	351	22	ear	ear	NOUN
admet-2268	351	23	skin	skin	NOUN
admet-2268	351	24	in	in	ADP
admet-2268	351	25	the	the	DET
admet-2268	351	26	franz	franz	NOUN
admet-2268	351	27	diffusion	diffusion	NOUN
admet-2268	351	28	assembly	assembly	NOUN
admet-2268	351	29	for	for	ADP
admet-2268	351	30	6	6	NUM
admet-2268	351	31	h.	h.	PROPN
admet-2268	351	32	pig	pig	NOUN
admet-2268	351	33	skin	skin	NOUN
admet-2268	351	34	has	have	AUX
admet-2268	351	35	been	be	AUX
admet-2268	351	36	shown	show	VERB
admet-2268	351	37	to	to	PART
admet-2268	351	38	be	be	AUX
admet-2268	351	39	a	a	DET
admet-2268	351	40	good	good	ADJ
admet-2268	351	41	surrogate	surrogate	NOUN
admet-2268	351	42	for	for	ADP
admet-2268	351	43	human	human	ADJ
admet-2268	351	44	skin	skin	NOUN
admet-2268	351	45	and	and	CCONJ
admet-2268	351	46	is	be	AUX
admet-2268	351	47	commonly	commonly	ADV
admet-2268	351	48	used	use	VERB
admet-2268	351	49	in	in	ADP
admet-2268	351	50	topical	topical	ADJ
admet-2268	351	51	drug	drug	NOUN
admet-2268	351	52	delivery	delivery	NOUN
admet-2268	351	53	for	for	ADP
admet-2268	351	54	in	in	ADP
admet-2268	351	55	vitro	vitro	X
admet-2268	351	56	studies	study	NOUN
admet-2268	351	57	[	[	X
admet-2268	351	58	60	60	NUM
admet-2268	351	59	]	]	PUNCT
admet-2268	351	60	.	.	PUNCT
admet-2268	352	1	the	the	DET
admet-2268	352	2	cumulative	cumulative	ADJ
admet-2268	352	3	drug	drug	NOUN
admet-2268	352	4	permeation	permeation	NOUN
admet-2268	352	5	of	of	ADP
admet-2268	352	6	berberine	berberine	PROPN
admet-2268	352	7	hcl	hcl	PROPN
admet-2268	352	8	and	and	CCONJ
admet-2268	352	9	diacerein	diacerein	ADJ
admet-2268	352	10	was	be	AUX
admet-2268	352	11	found	find	VERB
admet-2268	352	12	to	to	PART
admet-2268	352	13	be	be	AUX
admet-2268	352	14	7.286	7.286	NUM
admet-2268	352	15	and	and	CCONJ
admet-2268	352	16	10.41	10.41	NUM
admet-2268	353	1	µg	µg	DET
admet-2268	353	2	cm-2	cm-2	NOUN
admet-2268	353	3	,	,	PUNCT
admet-2268	353	4	respectively	respectively	ADV
admet-2268	353	5	.	.	PUNCT
admet-2268	354	1	berberine	berberine	PROPN
admet-2268	354	2	hcl	hcl	PROPN
admet-2268	354	3	exhibited	exhibit	VERB
admet-2268	354	4	a	a	DET
admet-2268	354	5	flux	flux	NOUN
admet-2268	354	6	of	of	ADP
admet-2268	354	7	0.0224	0.0224	NUM
admet-2268	354	8	µg	µg	NOUN
admet-2268	354	9	cm-2	cm-2	NOUN
admet-2268	354	10	h-1	h-1	ADJ
admet-2268	354	11	and	and	CCONJ
admet-2268	354	12	a	a	DET
admet-2268	354	13	permeation	permeation	NOUN
admet-2268	354	14	coefficient	coefficient	NOUN
admet-2268	354	15	(	(	PUNCT
admet-2268	354	16	kp	kp	INTJ
admet-2268	354	17	)	)	PUNCT
admet-2268	354	18	of	of	ADP
admet-2268	354	19	2.24	2.24	NUM
admet-2268	354	20	cm	cm	NOUN
admet-2268	354	21	h-1	h-1	NOUN
admet-2268	354	22	and	and	CCONJ
admet-2268	354	23	diacerein	diacerein	ADV
admet-2268	354	24	exhibited	exhibit	VERB
admet-2268	354	25	a	a	DET
admet-2268	354	26	flux	flux	NOUN
admet-2268	354	27	of	of	ADP
admet-2268	354	28	0.0462	0.0462	NUM
admet-2268	354	29	µg	µg	NOUN
admet-2268	354	30	cm-2	cm-2	NOUN
admet-2268	354	31	h-1	h-1	ADJ
admet-2268	354	32	and	and	CCONJ
admet-2268	354	33	kp	kp	PROPN
admet-2268	354	34	of	of	ADP
admet-2268	354	35	4.62	4.62	NUM
admet-2268	354	36	cm	cm	NOUN
admet-2268	354	37	h-1	h-1	NOUN
admet-2268	354	38	(	(	PUNCT
admet-2268	354	39	figure	figure	NOUN
admet-2268	354	40	11	11	NUM
admet-2268	354	41	)	)	PUNCT
admet-2268	354	42	.	.	PUNCT
admet-2268	355	1	the	the	DET
admet-2268	355	2	results	result	NOUN
admet-2268	355	3	confirmed	confirm	VERB
admet-2268	355	4	the	the	DET
admet-2268	355	5	movement	movement	NOUN
admet-2268	355	6	of	of	ADP
admet-2268	355	7	transferosomes	transferosome	NOUN
admet-2268	355	8	through	through	ADP
admet-2268	355	9	the	the	DET
admet-2268	355	10	skin	skin	NOUN
admet-2268	355	11	via	via	ADP
admet-2268	355	12	deformability	deformability	NOUN
admet-2268	355	13	property	property	NOUN
admet-2268	355	14	and	and	CCONJ
admet-2268	355	15	the	the	DET
admet-2268	355	16	driving	drive	VERB
admet-2268	355	17	force	force	NOUN
admet-2268	355	18	of	of	ADP
admet-2268	355	19	the	the	DET
admet-2268	355	20	osmotic	osmotic	ADJ
admet-2268	355	21	gradient	gradient	NOUN
admet-2268	355	22	[	[	X
admet-2268	355	23	61	61	NUM
admet-2268	355	24	]	]	PUNCT
admet-2268	355	25	.	.	PUNCT
admet-2268	356	1	in	in	ADP
admet-2268	356	2	addition	addition	NOUN
admet-2268	356	3	,	,	PUNCT
admet-2268	356	4	transferosomes	transferosome	NOUN
admet-2268	356	5	are	be	AUX
admet-2268	356	6	supposed	suppose	VERB
admet-2268	356	7	to	to	PART
admet-2268	356	8	be	be	AUX
admet-2268	356	9	passed	pass	VERB
admet-2268	356	10	through	through	ADP
admet-2268	356	11	the	the	DET
admet-2268	356	12	stratum	stratum	NOUN
admet-2268	356	13	corneum	corneum	NOUN
admet-2268	356	14	,	,	PUNCT
admet-2268	356	15	and	and	CCONJ
admet-2268	356	16	drug	drug	NOUN
admet-2268	356	17	partitioning	partitioning	NOUN
admet-2268	356	18	occurs	occur	VERB
admet-2268	356	19	between	between	ADP
admet-2268	356	20	the	the	DET
admet-2268	356	21	lipid	lipid	ADJ
admet-2268	356	22	part	part	NOUN
admet-2268	356	23	of	of	ADP
admet-2268	356	24	both	both	DET
admet-2268	356	25	nanocarriers	nanocarrier	NOUN
admet-2268	356	26	and	and	CCONJ
admet-2268	356	27	the	the	DET
admet-2268	356	28	stratum	stratum	NOUN
admet-2268	356	29	corneum	corneum	VERB
admet-2268	356	30	[	[	X
admet-2268	356	31	13	13	NUM
admet-2268	356	32	]	]	PUNCT
admet-2268	356	33	.	.	PUNCT
admet-2268	357	1	amplification	amplification	NOUN
admet-2268	357	2	of	of	ADP
admet-2268	357	3	stratum	stratum	NOUN
admet-2268	357	4	corneum	corneum	VERB
admet-2268	357	5	membrane	membrane	NOUN
admet-2268	357	6	fluidity	fluidity	NOUN
admet-2268	357	7	and	and	CCONJ
admet-2268	357	8	intercellular	intercellular	ADJ
admet-2268	357	9	lipids	lipids	ADJ
admet-2268	357	10	destabilization	destabilization	NOUN
admet-2268	357	11	could	could	AUX
admet-2268	357	12	be	be	AUX
admet-2268	357	13	another	another	DET
admet-2268	357	14	possible	possible	ADJ
admet-2268	357	15	reason	reason	NOUN
admet-2268	357	16	for	for	ADP
admet-2268	357	17	enhanced	enhanced	ADJ
admet-2268	357	18	skin	skin	NOUN
admet-2268	357	19	permeation	permeation	NOUN
admet-2268	357	20	[	[	X
admet-2268	357	21	62	62	NUM
admet-2268	357	22	]	]	PUNCT
admet-2268	357	23	.	.	PUNCT
admet-2268	358	1	time	time	NOUN
admet-2268	358	2	,	,	PUNCT
admet-2268	358	3	min	min	NOUN
admet-2268	358	4	figure	figure	NOUN
admet-2268	358	5	11	11	NUM
admet-2268	358	6	.	.	PUNCT
admet-2268	359	1	results	result	NOUN
admet-2268	359	2	of	of	ADP
admet-2268	359	3	ex	ex	PRON
admet-2268	359	4	vivo	vivo	ADJ
admet-2268	359	5	permeation	permeation	NOUN
admet-2268	359	6	studies	study	NOUN
admet-2268	359	7	in	in	ADP
admet-2268	359	8	pig	pig	NOUN
admet-2268	359	9	skin	skin	NOUN
admet-2268	359	10	(	(	PUNCT
admet-2268	359	11	data	data	NOUN
admet-2268	359	12	presents	present	VERB
admet-2268	359	13	mean±sd	mean±sd	PROPN
admet-2268	359	14	,	,	PUNCT
admet-2268	359	15	n	n	NOUN
admet-2268	359	16	=	=	SYM
admet-2268	359	17	3	3	NUM
admet-2268	359	18	)	)	PUNCT
admet-2268	359	19	.	.	PUNCT
admet-2268	360	1	raman	raman	NOUN
admet-2268	360	2	analysis	analysis	NOUN
admet-2268	360	3	raman	raman	NOUN
admet-2268	360	4	spectra	spectra	NOUN
admet-2268	360	5	facilitated	facilitate	VERB
admet-2268	360	6	the	the	DET
admet-2268	360	7	identification	identification	NOUN
admet-2268	360	8	of	of	ADP
admet-2268	360	9	active	active	ADJ
admet-2268	360	10	vibrational	vibrational	ADJ
admet-2268	360	11	modes	mode	NOUN
admet-2268	360	12	in	in	ADP
admet-2268	360	13	the	the	DET
admet-2268	360	14	target	target	NOUN
admet-2268	360	15	species	specie	NOUN
admet-2268	360	16	.	.	PUNCT
admet-2268	361	1	this	this	PRON
admet-2268	361	2	was	be	AUX
admet-2268	361	3	done	do	VERB
admet-2268	361	4	by	by	ADP
admet-2268	361	5	comparing	compare	VERB
admet-2268	361	6	the	the	DET
admet-2268	361	7	spectra	spectra	NOUN
admet-2268	361	8	obtained	obtain	VERB
admet-2268	361	9	for	for	ADP
admet-2268	361	10	blank	blank	ADJ
admet-2268	361	11	pig	pig	NOUN
admet-2268	361	12	skin	skin	NOUN
admet-2268	361	13	,	,	PUNCT
admet-2268	361	14	optimized	optimize	VERB
admet-2268	361	15	formulation	formulation	NOUN
admet-2268	361	16	(	(	PUNCT
admet-2268	361	17	formulation	formulation	NOUN
admet-2268	361	18	ddt-10	ddt-10	VERB
admet-2268	361	19	)	)	PUNCT
admet-2268	361	20	,	,	PUNCT
admet-2268	361	21	and	and	CCONJ
admet-2268	361	22	pig	pig	NOUN
admet-2268	361	23	skin	skin	NOUN
admet-2268	361	24	treated	treat	VERB
admet-2268	361	25	with	with	ADP
admet-2268	361	26	optimized	optimize	VERB
admet-2268	361	27	formulation	formulation	NOUN
admet-2268	361	28	(	(	PUNCT
admet-2268	361	29	formulation	formulation	NOUN
admet-2268	361	30	ddt-10	ddt-10	VERB
admet-2268	361	31	)	)	PUNCT
admet-2268	361	32	.	.	PUNCT
admet-2268	362	1	the	the	DET
admet-2268	362	2	presence	presence	NOUN
admet-2268	362	3	of	of	ADP
admet-2268	362	4	other	other	ADJ
admet-2268	362	5	chemicals	chemical	NOUN
admet-2268	362	6	can	can	AUX
admet-2268	362	7	produce	produce	VERB
admet-2268	362	8	strong	strong	ADJ
admet-2268	362	9	fluorescence	fluorescence	NOUN
admet-2268	362	10	signals	signal	NOUN
admet-2268	362	11	that	that	PRON
admet-2268	362	12	can	can	AUX
admet-2268	362	13	disrupt	disrupt	VERB
admet-2268	362	14	and	and	CCONJ
admet-2268	362	15	coincide	coincide	VERB
admet-2268	362	16	with	with	ADP
admet-2268	362	17	the	the	DET
admet-2268	362	18	raman	raman	NOUN
admet-2268	362	19	signal	signal	NOUN
admet-2268	362	20	.	.	PUNCT
admet-2268	363	1	this	this	PRON
admet-2268	363	2	is	be	AUX
admet-2268	363	3	particularly	particularly	ADV
admet-2268	363	4	evident	evident	ADJ
admet-2268	363	5	in	in	ADP
admet-2268	363	6	intricate	intricate	ADJ
admet-2268	363	7	settings	setting	NOUN
admet-2268	363	8	like	like	ADP
admet-2268	363	9	the	the	DET
admet-2268	363	10	skin	skin	NOUN
admet-2268	363	11	,	,	PUNCT
admet-2268	363	12	where	where	SCONJ
admet-2268	363	13	melanin	melanin	NOUN
admet-2268	363	14	absorbs	absorb	VERB
admet-2268	363	15	visible	visible	ADJ
admet-2268	363	16	light	light	NOUN
admet-2268	363	17	.	.	PUNCT
admet-2268	364	1	so	so	ADV
admet-2268	364	2	,	,	PUNCT
admet-2268	364	3	the	the	DET
admet-2268	364	4	sample	sample	NOUN
admet-2268	364	5	analysis	analysis	NOUN
admet-2268	364	6	was	be	AUX
admet-2268	364	7	done	do	VERB
admet-2268	364	8	at	at	ADP
admet-2268	364	9	785	785	NUM
admet-2268	364	10	nm	nm	NOUN
admet-2268	364	11	(	(	PUNCT
admet-2268	364	12	nearinfrared	nearinfrare	VERB
admet-2268	364	13	reason	reason	NOUN
admet-2268	364	14	)	)	PUNCT
admet-2268	364	15	.	.	PUNCT
admet-2268	365	1	at	at	ADP
admet-2268	365	2	this	this	DET
admet-2268	365	3	wavelength	wavelength	NOUN
admet-2268	365	4	,	,	PUNCT
admet-2268	365	5	the	the	DET
admet-2268	365	6	fluorescence	fluorescence	NOUN
admet-2268	365	7	intensity	intensity	NOUN
admet-2268	365	8	diminishes	diminish	VERB
admet-2268	365	9	considerably	considerably	ADV
admet-2268	365	10	,	,	PUNCT
admet-2268	365	11	facilitating	facilitate	VERB
admet-2268	365	12	the	the	DET
admet-2268	365	13	accurate	accurate	ADJ
admet-2268	365	14	identification	identification	NOUN
admet-2268	365	15	of	of	ADP
admet-2268	365	16	raman	raman	NOUN
admet-2268	365	17	-	-	PUNCT
admet-2268	365	18	active	active	ADJ
admet-2268	365	19	vibrational	vibrational	ADJ
admet-2268	365	20	mode	mode	NOUN
admet-2268	365	21	peaks	peak	NOUN
admet-2268	365	22	[	[	X
admet-2268	365	23	25	25	NUM
admet-2268	365	24	]	]	PUNCT
admet-2268	365	25	.	.	PUNCT
admet-2268	366	1	in	in	ADP
admet-2268	366	2	the	the	DET
admet-2268	366	3	present	present	ADJ
admet-2268	366	4	study	study	NOUN
admet-2268	366	5	,	,	PUNCT
admet-2268	366	6	the	the	DET
admet-2268	366	7	optimized	optimize	VERB
admet-2268	366	8	formulation	formulation	NOUN
admet-2268	366	9	(	(	PUNCT
admet-2268	366	10	ddt-10	ddt-10	PROPN
admet-2268	366	11	)	)	PUNCT
admet-2268	366	12	exhibited	exhibit	VERB
admet-2268	366	13	c	c	X
admet-2268	366	14	=	=	NOUN
admet-2268	366	15	o	o	X
admet-2268	366	16	at	at	ADP
admet-2268	366	17	1710	1710	NUM
admet-2268	366	18	cm-1	cm-1	NOUN
admet-2268	366	19	,	,	PUNCT
admet-2268	366	20	broadened	broaden	VERB
admet-2268	366	21	and	and	CCONJ
admet-2268	366	22	shifted	shift	VERB
admet-2268	366	23	by	by	ADP
admet-2268	366	24	h	h	NOUN
admet-2268	366	25	-	-	PUNCT
admet-2268	366	26	bonding	bonding	NOUN
admet-2268	366	27	observed	observe	VERB
admet-2268	366	28	at	at	ADP
admet-2268	366	29	3152	3152	NUM
admet-2268	366	30	cm-1	cm-1	VERB
admet-2268	366	31	in	in	ADP
admet-2268	366	32	the	the	DET
admet-2268	366	33	nh	nh	PROPN
admet-2268	366	34	group	group	NOUN
admet-2268	366	35	and	and	CCONJ
admet-2268	366	36	3318	3318	NUM
admet-2268	366	37	cm-1	cm-1	VERB
admet-2268	366	38	in	in	ADP
admet-2268	366	39	the	the	DET
admet-2268	366	40	oh	oh	PROPN
admet-2268	366	41	group	group	NOUN
admet-2268	366	42	,	,	PUNCT
admet-2268	366	43	respectively	respectively	ADV
admet-2268	366	44	.	.	PUNCT
admet-2268	367	1	in	in	ADP
admet-2268	367	2	addition	addition	NOUN
admet-2268	367	3	,	,	PUNCT
admet-2268	367	4	the	the	DET
admet-2268	367	5	raman	raman	NOUN
admet-2268	367	6	spectra	spectra	NOUN
admet-2268	367	7	of	of	ADP
admet-2268	367	8	the	the	DET
admet-2268	367	9	permeated	permeate	VERB
admet-2268	367	10	optimized	optimize	VERB
admet-2268	367	11	formulation	formulation	NOUN
admet-2268	367	12	in	in	ADP
admet-2268	367	13	pig	pig	NOUN
admet-2268	367	14	skin	skin	NOUN
admet-2268	367	15	revealed	reveal	VERB
admet-2268	367	16	the	the	DET
admet-2268	367	17	c	c	PROPN
admet-2268	367	18	=	=	NOUN
admet-2268	367	19	o	o	ADJ
admet-2268	367	20	functional	functional	ADJ
admet-2268	367	21	group	group	NOUN
admet-2268	367	22	presence	presence	NOUN
admet-2268	367	23	at	at	ADP
admet-2268	367	24	1714	1714	NUM
admet-2268	367	25	cm-1	cm-1	NOUN
admet-2268	367	26	,	,	PUNCT
admet-2268	367	27	broadened	broaden	VERB
admet-2268	367	28	and	and	CCONJ
admet-2268	367	29	shifted	shift	VERB
admet-2268	367	30	by	by	ADP
admet-2268	367	31	h	h	NOUN
admet-2268	367	32	-	-	PUNCT
admet-2268	367	33	bonding	bonding	NOUN
admet-2268	367	34	observed	observe	VERB
admet-2268	367	35	at	at	ADP
admet-2268	367	36	3154	3154	NUM
admet-2268	367	37	cm-1	cm-1	VERB
admet-2268	367	38	in	in	ADP
admet-2268	367	39	the	the	DET
admet-2268	367	40	nh	nh	PROPN
admet-2268	367	41	group	group	NOUN
admet-2268	367	42	and	and	CCONJ
admet-2268	367	43	at	at	ADP
admet-2268	367	44	3326	3326	NUM
admet-2268	367	45	cm-1	cm-1	VERB
admet-2268	367	46	in	in	ADP
admet-2268	367	47	the	the	DET
admet-2268	367	48	oh	oh	PROPN
admet-2268	367	49	group	group	NOUN
admet-2268	367	50	,	,	PUNCT
admet-2268	367	51	respectively	respectively	ADV
admet-2268	367	52	(	(	PUNCT
admet-2268	367	53	figure	figure	NOUN
admet-2268	367	54	12a	12a	NOUN
admet-2268	367	55	)	)	PUNCT
admet-2268	367	56	.	.	PUNCT
admet-2268	368	1	these	these	DET
admet-2268	368	2	spectral	spectral	ADJ
admet-2268	368	3	results	result	NOUN
admet-2268	368	4	confirmed	confirm	VERB
admet-2268	368	5	the	the	DET
admet-2268	368	6	presence	presence	NOUN
admet-2268	368	7	of	of	ADP
admet-2268	368	8	berberine	berberine	PROPN
admet-2268	368	9	hcl	hcl	PROPN
admet-2268	368	10	and	and	CCONJ
admet-2268	368	11	diacerein	diacerein	ADJ
admet-2268	368	12	dual	dual	ADV
admet-2268	368	13	-	-	PUNCT
admet-2268	368	14	loaded	load	VERB
admet-2268	368	15	transferosomes	transferosome	NOUN
admet-2268	368	16	that	that	PRON
admet-2268	368	17	successfully	successfully	ADV
admet-2268	368	18	permeated	permeate	VERB
admet-2268	368	19	the	the	DET
admet-2268	368	20	stratum	stratum	NOUN
admet-2268	368	21	corneum	corneum	NOUN
admet-2268	368	22	because	because	SCONJ
admet-2268	368	23	of	of	ADP
admet-2268	368	24	their	their	PRON
admet-2268	368	25	deformability	deformability	NOUN
admet-2268	368	26	property	property	NOUN
admet-2268	368	27	without	without	ADP
admet-2268	368	28	any	any	DET
admet-2268	368	29	rupturing	rupturing	NOUN
admet-2268	368	30	.	.	PUNCT
admet-2268	369	1	the	the	DET
admet-2268	369	2	image	image	NOUN
admet-2268	369	3	of	of	ADP
admet-2268	369	4	blank	blank	ADJ
admet-2268	369	5	pig	pig	NOUN
admet-2268	369	6	skin	skin	NOUN
admet-2268	369	7	,	,	PUNCT
admet-2268	369	8	observed	observe	VERB
admet-2268	369	9	in	in	ADP
admet-2268	369	10	the	the	DET
admet-2268	369	11	raman	raman	NOUN
admet-2268	369	12	spectroscopy	spectroscopy	NOUN
admet-2268	369	13	,	,	PUNCT
admet-2268	369	14	exhibited	exhibit	VERB
admet-2268	369	15	a	a	DET
admet-2268	369	16	reddish	reddish	ADJ
admet-2268	369	17	part	part	NOUN
admet-2268	369	18	due	due	ADP
admet-2268	369	19	to	to	ADP
admet-2268	369	20	erythrocytes	erythrocyte	NOUN
admet-2268	369	21	and	and	CCONJ
admet-2268	369	22	other	other	ADJ
admet-2268	369	23	blood	blood	NOUN
admet-2268	369	24	constituents	constituent	NOUN
admet-2268	369	25	(	(	PUNCT
admet-2268	369	26	figure	figure	NOUN
admet-2268	369	27	12b	12b	NOUN
admet-2268	369	28	)	)	PUNCT
admet-2268	369	29	.	.	PUNCT
admet-2268	370	1	on	on	ADP
admet-2268	370	2	the	the	DET
admet-2268	370	3	other	other	ADJ
admet-2268	370	4	side	side	NOUN
admet-2268	370	5	,	,	PUNCT
admet-2268	370	6	the	the	DET
admet-2268	370	7	transferosomes	transferosome	NOUN
admet-2268	370	8	permeated	permeate	VERB
admet-2268	370	9	pig	pig	NOUN
admet-2268	370	10	skin	skin	NOUN
admet-2268	370	11	exhibited	exhibit	VERB
admet-2268	370	12	a	a	DET
admet-2268	370	13	yellowish	yellowish	ADJ
admet-2268	370	14	appearance	appearance	NOUN
admet-2268	370	15	that	that	PRON
admet-2268	370	16	confirmed	confirm	VERB
admet-2268	370	17	the	the	DET
admet-2268	370	18	permeation	permeation	NOUN
admet-2268	370	19	in	in	ADP
admet-2268	370	20	the	the	DET
admet-2268	370	21	skin	skin	NOUN
admet-2268	370	22	by	by	ADP
admet-2268	370	23	transferosomes	transferosome	NOUN
admet-2268	370	24	(	(	PUNCT
admet-2268	370	25	figure	figure	NOUN
admet-2268	370	26	12c	12c	NUM
admet-2268	370	27	)	)	PUNCT
admet-2268	370	28	.	.	PUNCT
admet-2268	371	1	in	in	ADP
admet-2268	371	2	addition	addition	NOUN
admet-2268	371	3	,	,	PUNCT
admet-2268	371	4	the	the	DET
admet-2268	371	5	d	d	NOUN
admet-2268	371	6	-	-	NOUN
admet-2268	371	7	band	band	NOUN
admet-2268	371	8	and	and	CCONJ
admet-2268	371	9	g	g	NOUN
admet-2268	371	10	-	-	PUNCT
admet-2268	371	11	band	band	NOUN
admet-2268	371	12	in	in	ADP
admet-2268	371	13	the	the	DET
admet-2268	371	14	spectrum	spectrum	NOUN
admet-2268	371	15	of	of	ADP
admet-2268	371	16	optimized	optimize	VERB
admet-2268	371	17	formulation	formulation	NOUN
admet-2268	371	18	and	and	CCONJ
admet-2268	371	19	pig	pig	NOUN
admet-2268	371	20	skin	skin	NOUN
admet-2268	371	21	treated	treat	VERB
admet-2268	371	22	with	with	ADP
admet-2268	371	23	optimized	optimize	VERB
admet-2268	371	24	formulation	formulation	NOUN
admet-2268	371	25	(	(	PUNCT
admet-2268	371	26	formulation	formulation	NOUN
admet-2268	371	27	ddt-10	ddt-10	NOUN
admet-2268	371	28	)	)	PUNCT
admet-2268	371	29	appeared	appear	VERB
admet-2268	371	30	at	at	ADP
admet-2268	371	31	1322	1322	NUM
admet-2268	371	32	and	and	CCONJ
admet-2268	371	33	1548	1548	NUM
admet-2268	371	34	cm-1	cm-1	NOUN
admet-2268	371	35	,	,	PUNCT
admet-2268	371	36	respectively	respectively	ADV
admet-2268	371	37	.	.	PUNCT
admet-2268	372	1	c	c	NOUN
admet-2268	372	2	u	u	NOUN
admet-2268	372	3	m	m	VERB
admet-2268	372	4	u	u	VERB
admet-2268	372	5	la	la	X
admet-2268	372	6	ti	ti	X
admet-2268	372	7	ve	ve	PROPN
admet-2268	372	8	d	d	PROPN
admet-2268	372	9	ru	ru	PROPN
admet-2268	372	10	g	g	PROPN
admet-2268	372	11	re	re	ADP
admet-2268	372	12	le	le	X
admet-2268	372	13	as	as	ADP
admet-2268	372	14	e	e	PROPN
admet-2268	372	15	,	,	PUNCT
admet-2268	372	16	%	%	NOUN
admet-2268	372	17	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	PROPN
admet-2268	372	18	s.	s.	PROPN
admet-2268	372	19	singh	singh	PROPN
admet-2268	372	20	and	and	CCONJ
admet-2268	372	21	r.	r.	PROPN
admet-2268	372	22	awasthi	awasthi	PROPN
admet-2268	372	23	admet	admet	PROPN
admet-2268	372	24	&	&	CCONJ
admet-2268	372	25	dmpk	dmpk	PROPN
admet-2268	372	26	12(3	12(3	PROPN
admet-2268	372	27	)	)	PUNCT
admet-2268	372	28	(	(	PUNCT
admet-2268	372	29	2024	2024	NUM
admet-2268	372	30	)	)	PUNCT
admet-2268	372	31	553	553	NUM
admet-2268	372	32	-	-	SYM
admet-2268	372	33	580	580	NUM
admet-2268	372	34	574	574	NUM
admet-2268	372	35	figure	figure	NOUN
admet-2268	372	36	12	12	NUM
admet-2268	372	37	.	.	PUNCT
admet-2268	373	1	results	result	NOUN
admet-2268	373	2	of	of	ADP
admet-2268	373	3	raman	raman	ADJ
admet-2268	373	4	analysis	analysis	NOUN
admet-2268	373	5	:	:	PUNCT
admet-2268	373	6	a	a	DET
admet-2268	373	7	spectra	spectra	NOUN
admet-2268	373	8	of	of	ADP
admet-2268	373	9	treated	treat	VERB
admet-2268	373	10	pig	pig	NOUN
admet-2268	373	11	skin	skin	NOUN
admet-2268	373	12	,	,	PUNCT
admet-2268	373	13	b	b	NOUN
admet-2268	373	14	image	image	NOUN
admet-2268	373	15	of	of	ADP
admet-2268	373	16	blank	blank	ADJ
admet-2268	373	17	pig	pig	NOUN
admet-2268	373	18	skin	skin	NOUN
admet-2268	373	19	and	and	CCONJ
admet-2268	373	20	c	c	NOUN
admet-2268	373	21	image	image	NOUN
admet-2268	373	22	of	of	ADP
admet-2268	373	23	pig	pig	NOUN
admet-2268	373	24	skin	skin	NOUN
admet-2268	373	25	treated	treat	VERB
admet-2268	373	26	with	with	ADP
admet-2268	373	27	optimized	optimize	VERB
admet-2268	373	28	formulation	formulation	NOUN
admet-2268	373	29	(	(	PUNCT
admet-2268	373	30	formulation	formulation	NOUN
admet-2268	373	31	ddt-10	ddt-10	VERB
admet-2268	373	32	)	)	PUNCT
admet-2268	373	33	.	.	PUNCT
admet-2268	374	1	skin	skin	NOUN
admet-2268	374	2	irritation	irritation	NOUN
admet-2268	374	3	test	test	NOUN
admet-2268	374	4	no	no	DET
admet-2268	374	5	change	change	NOUN
admet-2268	374	6	in	in	ADP
admet-2268	374	7	the	the	DET
admet-2268	374	8	skin	skin	NOUN
admet-2268	374	9	conditions	condition	NOUN
admet-2268	374	10	or	or	CCONJ
admet-2268	374	11	irritation	irritation	NOUN
admet-2268	374	12	was	be	AUX
admet-2268	374	13	recorded	record	VERB
admet-2268	374	14	in	in	ADP
admet-2268	374	15	animals	animal	NOUN
admet-2268	374	16	treated	treat	VERB
admet-2268	374	17	with	with	ADP
admet-2268	374	18	the	the	DET
admet-2268	374	19	optimized	optimize	VERB
admet-2268	374	20	formulation	formulation	NOUN
admet-2268	374	21	(	(	PUNCT
admet-2268	374	22	formulation	formulation	NOUN
admet-2268	374	23	ddt-10	ddt-10	PROPN
admet-2268	374	24	)	)	PUNCT
admet-2268	374	25	(	(	PUNCT
admet-2268	374	26	figure	figure	NOUN
admet-2268	374	27	13	13	NUM
admet-2268	374	28	)	)	PUNCT
admet-2268	374	29	.	.	PUNCT
admet-2268	375	1	results	result	NOUN
admet-2268	375	2	from	from	ADP
admet-2268	375	3	the	the	DET
admet-2268	375	4	visual	visual	ADJ
admet-2268	375	5	assessment	assessment	NOUN
admet-2268	375	6	demonstrated	demonstrate	VERB
admet-2268	375	7	no	no	DET
admet-2268	375	8	irritation	irritation	NOUN
admet-2268	375	9	scores	score	NOUN
admet-2268	375	10	(	(	PUNCT
admet-2268	375	11	table	table	NOUN
admet-2268	375	12	7	7	NUM
admet-2268	375	13	)	)	PUNCT
admet-2268	375	14	.	.	PUNCT
admet-2268	376	1	therefore	therefore	ADV
admet-2268	376	2	,	,	PUNCT
admet-2268	376	3	the	the	DET
admet-2268	376	4	formulated	formulated	ADJ
admet-2268	376	5	berberine	berberine	NOUN
admet-2268	376	6	hcl	hcl	PROPN
admet-2268	376	7	and	and	CCONJ
admet-2268	376	8	diacerein	diacerein	ADV
admet-2268	376	9	-	-	PUNCT
admet-2268	376	10	loaded	load	VERB
admet-2268	376	11	transferosomes	transferosome	NOUN
admet-2268	376	12	can	can	AUX
admet-2268	376	13	be	be	AUX
admet-2268	376	14	recommended	recommend	VERB
admet-2268	376	15	as	as	ADV
admet-2268	376	16	safe	safe	ADJ
admet-2268	376	17	for	for	ADP
admet-2268	376	18	topical	topical	ADJ
admet-2268	376	19	application	application	NOUN
admet-2268	376	20	.	.	PUNCT
admet-2268	377	1	table	table	NOUN
admet-2268	377	2	7	7	NUM
admet-2268	377	3	.	.	PUNCT
admet-2268	378	1	results	result	NOUN
admet-2268	378	2	of	of	ADP
admet-2268	378	3	erythema	erythema	ADJ
admet-2268	378	4	scores	score	NOUN
admet-2268	378	5	after	after	ADP
admet-2268	378	6	application	application	NOUN
admet-2268	378	7	of	of	ADP
admet-2268	378	8	normal	normal	ADJ
admet-2268	378	9	saline	saline	NOUN
admet-2268	378	10	and	and	CCONJ
admet-2268	378	11	optimized	optimize	VERB
admet-2268	378	12	transferosomes	transferosome	NOUN
admet-2268	378	13	(	(	PUNCT
admet-2268	378	14	formulation	formulation	NOUN
admet-2268	378	15	ddt-10	ddt-10	VERB
admet-2268	378	16	)	)	PUNCT
admet-2268	378	17	to	to	ADP
admet-2268	378	18	the	the	DET
admet-2268	378	19	depilated	depilate	VERB
admet-2268	378	20	dorsal	dorsal	NOUN
admet-2268	378	21	skin	skin	NOUN
admet-2268	378	22	of	of	ADP
admet-2268	378	23	imiquimod	imiquimod	ADV
admet-2268	378	24	-	-	PUNCT
admet-2268	378	25	induced	induce	VERB
admet-2268	378	26	psoriatic	psoriatic	ADJ
admet-2268	378	27	balb	balb	NOUN
admet-2268	378	28	/	/	SYM
admet-2268	378	29	c	c	NOUN
admet-2268	378	30	mice	mouse	NOUN
admet-2268	378	31	.	.	PUNCT
admet-2268	379	1	day	day	NOUN
admet-2268	379	2	reference	reference	NOUN
admet-2268	379	3	(	(	PUNCT
admet-2268	379	4	normal	normal	ADJ
admet-2268	379	5	saline	saline	NOUN
admet-2268	379	6	)	)	PUNCT
admet-2268	379	7	optimized	optimize	VERB
admet-2268	379	8	formulation	formulation	NOUN
admet-2268	379	9	(	(	PUNCT
admet-2268	379	10	formulation	formulation	NOUN
admet-2268	379	11	ddt-10	ddt-10	NOUN
admet-2268	379	12	)	)	PUNCT
admet-2268	379	13	1	1	NUM
admet-2268	379	14	0	0	NUM
admet-2268	379	15	0	0	NUM
admet-2268	379	16	2	2	NUM
admet-2268	379	17	0	0	NUM
admet-2268	379	18	0	0	NUM
admet-2268	379	19	3	3	NUM
admet-2268	379	20	1	1	NUM
admet-2268	379	21	1	1	NUM
admet-2268	379	22	4	4	NUM
admet-2268	379	23	2	2	NUM
admet-2268	379	24	1	1	NUM
admet-2268	379	25	5	5	NUM
admet-2268	379	26	3	3	NUM
admet-2268	379	27	0	0	NUM
admet-2268	379	28	6	6	NUM
admet-2268	379	29	4	4	NUM
admet-2268	379	30	0	0	NUM
admet-2268	379	31	7	7	NUM
admet-2268	379	32	4	4	NUM
admet-2268	379	33	0	0	NUM
admet-2268	379	34	figure	figure	NOUN
admet-2268	379	35	13	13	NUM
admet-2268	379	36	.	.	PUNCT
admet-2268	380	1	visual	visual	ADJ
admet-2268	380	2	assessment	assessment	NOUN
admet-2268	380	3	of	of	ADP
admet-2268	380	4	skin	skin	NOUN
admet-2268	380	5	irritation	irritation	NOUN
admet-2268	380	6	in	in	ADP
admet-2268	380	7	imiquad	imiquad	NOUN
admet-2268	380	8	®	®	NOUN
admet-2268	380	9	cream	cream	NOUN
admet-2268	380	10	treated	treat	VERB
admet-2268	380	11	male	male	ADJ
admet-2268	380	12	balb	balb	ADJ
admet-2268	380	13	/	/	SYM
admet-2268	380	14	c	c	NOUN
admet-2268	380	15	mice	mouse	NOUN
admet-2268	380	16	.	.	PUNCT
admet-2268	381	1	images	image	NOUN
admet-2268	381	2	a	a	PRON
admet-2268	381	3	and	and	CCONJ
admet-2268	381	4	c	c	NOUN
admet-2268	381	5	are	be	AUX
admet-2268	381	6	imiquad	imiquad	NOUN
admet-2268	381	7	®	®	NOUN
admet-2268	381	8	creamtreated	creamtreate	VERB
admet-2268	381	9	mice	mouse	NOUN
admet-2268	381	10	on	on	ADP
admet-2268	381	11	day	day	NOUN
admet-2268	381	12	0	0	NUM
admet-2268	381	13	.	.	PUNCT
admet-2268	382	1	image	image	PROPN
admet-2268	382	2	b	b	PROPN
admet-2268	382	3	shows	show	VERB
admet-2268	382	4	signs	sign	NOUN
admet-2268	382	5	of	of	ADP
admet-2268	382	6	evident	evident	ADJ
admet-2268	382	7	transformation	transformation	NOUN
admet-2268	382	8	and	and	CCONJ
admet-2268	382	9	erythema	erythema	ADJ
admet-2268	382	10	in	in	ADP
admet-2268	382	11	psoriatic	psoriatic	ADJ
admet-2268	382	12	mice	mouse	NOUN
admet-2268	382	13	treated	treat	VERB
admet-2268	382	14	with	with	ADP
admet-2268	382	15	saline	saline	NOUN
admet-2268	382	16	on	on	ADP
admet-2268	382	17	day	day	NOUN
admet-2268	382	18	7	7	NUM
admet-2268	382	19	.	.	PUNCT
admet-2268	382	20	image	image	NOUN
admet-2268	382	21	d	d	NOUN
admet-2268	382	22	shows	show	VERB
admet-2268	382	23	no	no	DET
admet-2268	382	24	irritation	irritation	NOUN
admet-2268	382	25	or	or	CCONJ
admet-2268	382	26	erythema	erythema	VERB
admet-2268	382	27	in	in	ADP
admet-2268	382	28	psoriatic	psoriatic	ADJ
admet-2268	382	29	mice	mouse	NOUN
admet-2268	382	30	treated	treat	VERB
admet-2268	382	31	with	with	ADP
admet-2268	382	32	optimized	optimize	VERB
admet-2268	382	33	transferosomes	transferosome	NOUN
admet-2268	382	34	on	on	ADP
admet-2268	382	35	day	day	NOUN
admet-2268	382	36	7	7	NUM
admet-2268	382	37	.	.	PUNCT
admet-2268	383	1	in	in	ADP
admet-2268	383	2	te	te	PROPN
admet-2268	383	3	n	n	CCONJ
admet-2268	383	4	si	si	INTJ
admet-2268	383	5	ty	ty	INTJ
admet-2268	383	6	,	,	PUNCT
admet-2268	383	7	a	a	DET
admet-2268	383	8	.u	.u	NOUN
admet-2268	383	9	.	.	PUNCT
admet-2268	384	1	raman	raman	NOUN
admet-2268	384	2	shift	shift	NOUN
admet-2268	384	3	,	,	PUNCT
admet-2268	384	4	cm-1	cm-1	X
admet-2268	384	5	admet	admet	PROPN
admet-2268	384	6	&	&	CCONJ
admet-2268	384	7	dmpk	dmpk	PROPN
admet-2268	384	8	12(3	12(3	PROPN
admet-2268	384	9	)	)	PUNCT
admet-2268	384	10	(	(	PUNCT
admet-2268	384	11	2024	2024	NUM
admet-2268	384	12	)	)	PUNCT
admet-2268	384	13	553	553	NUM
admet-2268	384	14	-	-	SYM
admet-2268	384	15	580	580	NUM
admet-2268	384	16	berberine	berberine	NOUN
admet-2268	384	17	hcl	hcl	PROPN
admet-2268	384	18	and	and	CCONJ
admet-2268	384	19	diacerein	diacerein	ADV
admet-2268	384	20	loaded	load	VERB
admet-2268	384	21	dual	dual	ADJ
admet-2268	384	22	delivery	delivery	NOUN
admet-2268	384	23	transferosomes	transferosome	NOUN
admet-2268	384	24	doi	doi	PROPN
admet-2268	384	25	:	:	PUNCT
admet-2268	384	26	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	384	27	575	575	NUM
admet-2268	384	28	stability	stability	NOUN
admet-2268	384	29	study	study	NOUN
admet-2268	384	30	optimized	optimize	VERB
admet-2268	384	31	transferosomes	transferosome	NOUN
admet-2268	384	32	(	(	PUNCT
admet-2268	384	33	formulation	formulation	NOUN
admet-2268	384	34	ddt-10	ddt-10	NOUN
admet-2268	384	35	)	)	PUNCT
admet-2268	384	36	did	do	AUX
admet-2268	384	37	not	not	PART
admet-2268	384	38	significantly	significantly	ADV
admet-2268	384	39	change	change	VERB
admet-2268	384	40	their	their	PRON
admet-2268	384	41	physical	physical	ADJ
admet-2268	384	42	appearance	appearance	NOUN
admet-2268	384	43	.	.	PUNCT
admet-2268	385	1	no	no	DET
admet-2268	385	2	change	change	NOUN
admet-2268	385	3	in	in	ADP
admet-2268	385	4	morphology	morphology	NOUN
admet-2268	385	5	(	(	PUNCT
admet-2268	385	6	figure	figure	NOUN
admet-2268	385	7	14a	14a	NOUN
admet-2268	385	8	and	and	CCONJ
admet-2268	385	9	b	b	NOUN
admet-2268	385	10	)	)	PUNCT
admet-2268	385	11	or	or	CCONJ
admet-2268	385	12	vesicle	vesicle	NOUN
admet-2268	385	13	size	size	NOUN
admet-2268	385	14	(	(	PUNCT
admet-2268	385	15	figure	figure	NOUN
admet-2268	385	16	14e	14e	NOUN
admet-2268	385	17	and	and	CCONJ
admet-2268	385	18	f	f	X
admet-2268	385	19	)	)	PUNCT
admet-2268	385	20	was	be	AUX
admet-2268	385	21	recorded	record	VERB
admet-2268	385	22	.	.	PUNCT
admet-2268	386	1	ζ	ζ	NOUN
admet-2268	386	2	potentials	potential	NOUN
admet-2268	386	3	were	be	AUX
admet-2268	386	4	within	within	ADP
admet-2268	386	5	the	the	DET
admet-2268	386	6	range	range	NOUN
admet-2268	386	7	of	of	ADP
admet-2268	386	8	±30	±30	NUM
admet-2268	386	9	mv	mv	PROPN
admet-2268	386	10	,	,	PUNCT
admet-2268	386	11	indicating	indicate	VERB
admet-2268	386	12	the	the	DET
admet-2268	386	13	stable	stable	ADJ
admet-2268	386	14	nature	nature	NOUN
admet-2268	386	15	of	of	ADP
admet-2268	386	16	the	the	DET
admet-2268	386	17	formulation	formulation	NOUN
admet-2268	386	18	stored	store	VERB
admet-2268	386	19	at	at	ADP
admet-2268	386	20	4	4	NUM
admet-2268	386	21	°	°	ADP
admet-2268	386	22	c	c	NOUN
admet-2268	386	23	(	(	PUNCT
admet-2268	386	24	-25.4±1.8	-25.4±1.8	PROPN
admet-2268	386	25	mv	mv	NOUN
admet-2268	386	26	)	)	PUNCT
admet-2268	386	27	and	and	CCONJ
admet-2268	386	28	25±2	25±2	NUM
admet-2268	386	29	°	°	ADP
admet-2268	386	30	c	c	NOUN
admet-2268	386	31	(	(	PUNCT
admet-2268	386	32	-27.3±0.4	-27.3±0.4	PUNCT
admet-2268	386	33	mv	mv	VERB
admet-2268	386	34	)	)	PUNCT
admet-2268	386	35	for	for	ADP
admet-2268	386	36	3	3	NUM
admet-2268	386	37	months	month	NOUN
admet-2268	386	38	(	(	PUNCT
admet-2268	386	39	figure	figure	NOUN
admet-2268	386	40	14c	14c	PROPN
admet-2268	386	41	and	and	CCONJ
admet-2268	386	42	d	d	NOUN
admet-2268	386	43	,	,	PUNCT
admet-2268	386	44	respectively	respectively	ADV
admet-2268	386	45	)	)	PUNCT
admet-2268	386	46	.	.	PUNCT
admet-2268	387	1	zeta	zeta	PROPN
admet-2268	387	2	potential	potential	ADJ
admet-2268	387	3	distribution	distribution	NOUN
admet-2268	387	4	,	,	PUNCT
admet-2268	387	5	mv	mv	PROPN
admet-2268	387	6	zeta	zeta	VERB
admet-2268	387	7	potential	potential	ADJ
admet-2268	387	8	distribution	distribution	NOUN
admet-2268	387	9	,	,	PUNCT
admet-2268	387	10	mv	mv	PROPN
admet-2268	387	11	average	average	ADJ
admet-2268	387	12	particle	particle	NOUN
admet-2268	387	13	size	size	NOUN
admet-2268	387	14	:	:	PUNCT
admet-2268	387	15	111.9	111.9	NUM
admet-2268	387	16	nm	nm	ADJ
admet-2268	387	17	pdi	pdi	NOUN
admet-2268	387	18	=	=	PUNCT
admet-2268	387	19	0.295	0.295	NUM
admet-2268	387	20	intercept	intercept	NOUN
admet-2268	387	21	:	:	PUNCT
admet-2268	387	22	0.958	0.958	NUM
admet-2268	387	23	particle	particle	NOUN
admet-2268	387	24	siza	siza	NOUN
admet-2268	387	25	,	,	PUNCT
admet-2268	387	26	nm	nm	PRON
admet-2268	387	27	intensity	intensity	NOUN
admet-2268	387	28	,	,	PUNCT
admet-2268	387	29	%	%	INTJ
admet-2268	387	30	sd	sd	NOUN
admet-2268	387	31	peak	peak	NOUN
admet-2268	387	32	1	1	NUM
admet-2268	387	33	187.2	187.2	NUM
admet-2268	387	34	100.0	100.0	NUM
admet-2268	387	35	155.4	155.4	NUM
admet-2268	387	36	peak	peak	NOUN
admet-2268	387	37	2	2	NUM
admet-2268	387	38	0.0	0.0	NUM
admet-2268	387	39	0.0	0.0	NUM
admet-2268	387	40	0.0	0.0	NUM
admet-2268	387	41	peak	peak	NOUN
admet-2268	387	42	3	3	NUM
admet-2268	387	43	0.0	0.0	NUM
admet-2268	387	44	0.0	0.0	NUM
admet-2268	387	45	0.0	0.0	NUM
admet-2268	387	46	particle	particle	NOUN
admet-2268	387	47	size	size	NOUN
admet-2268	387	48	,	,	PUNCT
admet-2268	387	49	nm	nm	PRON
admet-2268	387	50	average	average	ADJ
admet-2268	387	51	particle	particle	NOUN
admet-2268	387	52	size	size	NOUN
admet-2268	387	53	:	:	PUNCT
admet-2268	387	54	114.1	114.1	NUM
admet-2268	387	55	nm	nm	ADJ
admet-2268	387	56	pdi	pdi	NOUN
admet-2268	387	57	=	=	PUNCT
admet-2268	387	58	0.292	0.292	NUM
admet-2268	387	59	intercept	intercept	NOUN
admet-2268	387	60	:	:	PUNCT
admet-2268	387	61	0.957	0.957	NUM
admet-2268	387	62	particle	particle	NOUN
admet-2268	387	63	siza	siza	NOUN
admet-2268	387	64	,	,	PUNCT
admet-2268	387	65	nm	nm	PRON
admet-2268	387	66	intensity	intensity	NOUN
admet-2268	387	67	,	,	PUNCT
admet-2268	387	68	%	%	INTJ
admet-2268	387	69	sd	sd	NOUN
admet-2268	387	70	peak	peak	NOUN
admet-2268	387	71	1	1	NUM
admet-2268	387	72	178.0	178.0	NUM
admet-2268	387	73	100	100	NUM
admet-2268	387	74	125.6	125.6	NUM
admet-2268	387	75	peak	peak	NOUN
admet-2268	387	76	2	2	NUM
admet-2268	387	77	0.0	0.0	NUM
admet-2268	387	78	0.0	0.0	NUM
admet-2268	387	79	0.0	0.0	NUM
admet-2268	387	80	peak	peak	NOUN
admet-2268	387	81	3	3	NUM
admet-2268	387	82	0.0	0.0	NUM
admet-2268	387	83	0.0	0.0	NUM
admet-2268	387	84	0.0	0.0	NUM
admet-2268	387	85	particle	particle	NOUN
admet-2268	387	86	size	size	NOUN
admet-2268	387	87	,	,	PUNCT
admet-2268	387	88	nm	nm	PRON
admet-2268	387	89	figure	figure	NOUN
admet-2268	387	90	14	14	NUM
admet-2268	387	91	.	.	PUNCT
admet-2268	388	1	tem	tem	PROPN
admet-2268	388	2	images	image	VERB
admet-2268	388	3	a	a	DET
admet-2268	388	4	and	and	CCONJ
admet-2268	388	5	b	b	NOUN
admet-2268	388	6	,	,	PUNCT
admet-2268	388	7	zeta	zeta	PROPN
admet-2268	388	8	potential	potential	ADJ
admet-2268	388	9	results	result	NOUN
admet-2268	388	10	c	c	PROPN
admet-2268	388	11	and	and	CCONJ
admet-2268	388	12	d	d	NOUN
admet-2268	388	13	,	,	PUNCT
admet-2268	388	14	particle	particle	NOUN
admet-2268	388	15	size	size	NOUN
admet-2268	388	16	distribution	distribution	NOUN
admet-2268	388	17	e	e	NOUN
admet-2268	388	18	and	and	CCONJ
admet-2268	388	19	f	f	PROPN
admet-2268	388	20	of	of	ADP
admet-2268	388	21	optimized	optimize	VERB
admet-2268	388	22	transferosomes	transferosome	NOUN
admet-2268	388	23	(	(	PUNCT
admet-2268	388	24	formulation	formulation	NOUN
admet-2268	388	25	ddt-10	ddt-10	NOUN
admet-2268	388	26	)	)	PUNCT
admet-2268	388	27	stored	store	VERB
admet-2268	388	28	at	at	ADP
admet-2268	388	29	4±1	4±1	NUM
admet-2268	388	30	°	°	ADP
admet-2268	388	31	c	c	NOUN
admet-2268	388	32	and	and	CCONJ
admet-2268	388	33	25±2	25±2	NUM
admet-2268	388	34	°	°	PROPN
admet-2268	388	35	c/	c/	NOUN
admet-2268	388	36	60±5	60±5	NOUN
admet-2268	388	37	%	%	NOUN
admet-2268	388	38	rh	rh	NOUN
admet-2268	388	39	for	for	ADP
admet-2268	388	40	3	3	NUM
admet-2268	388	41	months	month	NOUN
admet-2268	388	42	,	,	PUNCT
admet-2268	388	43	respectively	respectively	ADV
admet-2268	388	44	.	.	PUNCT
admet-2268	389	1	the	the	DET
admet-2268	389	2	entrapment	entrapment	ADJ
admet-2268	389	3	efficiency	efficiency	NOUN
admet-2268	389	4	of	of	ADP
admet-2268	389	5	the	the	DET
admet-2268	389	6	optimized	optimize	VERB
admet-2268	389	7	formulation	formulation	NOUN
admet-2268	389	8	stored	store	VERB
admet-2268	389	9	at	at	ADP
admet-2268	389	10	4	4	NUM
admet-2268	389	11	°	°	ADP
admet-2268	389	12	c	c	NOUN
admet-2268	389	13	for	for	ADP
admet-2268	389	14	3	3	NUM
admet-2268	389	15	months	month	NOUN
admet-2268	389	16	was	be	AUX
admet-2268	389	17	found	find	VERB
admet-2268	389	18	to	to	PART
admet-2268	389	19	be	be	AUX
admet-2268	389	20	88.86±1.3	88.86±1.3	NUM
admet-2268	389	21	and	and	CCONJ
admet-2268	389	22	89.89±1.2	89.89±1.2	NUM
admet-2268	389	23	%	%	NOUN
admet-2268	389	24	,	,	PUNCT
admet-2268	389	25	respectively	respectively	ADV
admet-2268	389	26	,	,	PUNCT
admet-2268	389	27	for	for	ADP
admet-2268	389	28	berberine	berberine	NOUN
admet-2268	389	29	hcl	hcl	PROPN
admet-2268	389	30	and	and	CCONJ
admet-2268	389	31	diacerein	diacerein	ADJ
admet-2268	389	32	.	.	PUNCT
admet-2268	390	1	the	the	DET
admet-2268	390	2	entrapment	entrapment	ADJ
admet-2268	390	3	efficiency	efficiency	NOUN
admet-2268	390	4	of	of	ADP
admet-2268	390	5	the	the	DET
admet-2268	390	6	optimized	optimize	VERB
admet-2268	390	7	formulation	formulation	NOUN
admet-2268	390	8	stored	store	VERB
admet-2268	390	9	at	at	ADP
admet-2268	390	10	25±2	25±2	NUM
admet-2268	390	11	°	°	ADP
admet-2268	390	12	c	c	NOUN
admet-2268	390	13	for	for	ADP
admet-2268	390	14	3	3	NUM
admet-2268	390	15	months	month	NOUN
admet-2268	390	16	was	be	AUX
admet-2268	390	17	found	find	VERB
admet-2268	390	18	to	to	PART
admet-2268	390	19	be	be	AUX
admet-2268	390	20	88.11±1.4	88.11±1.4	NUM
admet-2268	390	21	and	and	CCONJ
admet-2268	390	22	89.06±0.6	89.06±0.6	NUM
admet-2268	390	23	%	%	NOUN
admet-2268	390	24	,	,	PUNCT
admet-2268	390	25	respectively	respectively	ADV
admet-2268	390	26	,	,	PUNCT
admet-2268	390	27	for	for	ADP
admet-2268	390	28	berberine	berberine	NOUN
admet-2268	390	29	hcl	hcl	PROPN
admet-2268	390	30	and	and	CCONJ
admet-2268	390	31	diacerein	diacerein	ADJ
admet-2268	390	32	.	.	PUNCT
admet-2268	391	1	results	result	NOUN
admet-2268	391	2	indicated	indicate	VERB
admet-2268	391	3	no	no	DET
admet-2268	391	4	significant	significant	ADJ
admet-2268	391	5	leaching	leaching	NOUN
admet-2268	391	6	of	of	ADP
admet-2268	391	7	the	the	DET
admet-2268	391	8	drug	drug	NOUN
admet-2268	391	9	from	from	ADP
admet-2268	391	10	the	the	DET
admet-2268	391	11	vesicles	vesicle	NOUN
admet-2268	391	12	at	at	ADP
admet-2268	391	13	both	both	DET
admet-2268	391	14	storage	storage	NOUN
admet-2268	391	15	conditions	condition	NOUN
admet-2268	391	16	.	.	PUNCT
admet-2268	392	1	conclusions	conclusion	NOUN
admet-2268	392	2	this	this	DET
admet-2268	392	3	communication	communication	NOUN
admet-2268	392	4	reported	report	VERB
admet-2268	392	5	formulation	formulation	NOUN
admet-2268	392	6	and	and	CCONJ
admet-2268	392	7	optimization	optimization	NOUN
admet-2268	392	8	of	of	ADP
admet-2268	392	9	berberine	berberine	PROPN
admet-2268	392	10	hcl	hcl	PROPN
admet-2268	392	11	and	and	CCONJ
admet-2268	392	12	diacerein	diacerein	ADV
admet-2268	392	13	-	-	PUNCT
admet-2268	392	14	loaded	load	VERB
admet-2268	392	15	dualdelivery	dualdelivery	NOUN
admet-2268	392	16	transferosomes	transferosomes	PROPN
admet-2268	392	17	.	.	PUNCT
admet-2268	393	1	transferosomes	transferosome	NOUN
admet-2268	393	2	were	be	AUX
admet-2268	393	3	successfully	successfully	ADV
admet-2268	393	4	formulated	formulate	VERB
admet-2268	393	5	using	use	VERB
admet-2268	393	6	the	the	DET
admet-2268	393	7	thin	thin	ADJ
admet-2268	393	8	film	film	NOUN
admet-2268	393	9	hydration	hydration	NOUN
admet-2268	393	10	method	method	NOUN
admet-2268	393	11	.	.	PUNCT
admet-2268	394	1	the	the	DET
admet-2268	394	2	optimized	optimize	VERB
admet-2268	394	3	transferosomes	transferosome	NOUN
admet-2268	394	4	had	have	VERB
admet-2268	394	5	particle	particle	NOUN
admet-2268	394	6	size	size	NOUN
admet-2268	394	7	of	of	ADP
admet-2268	394	8	110.90±2.8	110.90±2.8	NUM
admet-2268	394	9	nm	nm	NOUN
admet-2268	394	10	along	along	ADP
admet-2268	394	11	with	with	ADP
admet-2268	394	12	high	high	ADJ
admet-2268	394	13	entrapment	entrapment	ADJ
admet-2268	394	14	efficiency	efficiency	NOUN
admet-2268	394	15	(	(	PUNCT
admet-2268	394	16	89.50±1.5	89.50±1.5	PROPN
admet-2268	394	17	of	of	ADP
admet-2268	394	18	berberine	berberine	PROPN
admet-2268	394	19	hcl	hcl	PROPN
admet-2268	394	20	and	and	CCONJ
admet-2268	394	21	91.23±1.8	91.23±1.8	NUM
admet-2268	394	22	%	%	NOUN
admet-2268	394	23	of	of	ADP
admet-2268	394	24	diacerein	diacerein	ADJ
admet-2268	394	25	)	)	PUNCT
admet-2268	394	26	and	and	CCONJ
admet-2268	394	27	outstanding	outstanding	ADJ
admet-2268	394	28	release	release	NOUN
admet-2268	394	29	profile	profile	NOUN
admet-2268	394	30	(	(	PUNCT
admet-2268	394	31	82.09±0.81	82.09±0.81	NUM
admet-2268	394	32	and	and	CCONJ
admet-2268	394	33	85.02±3.81	85.02±3.81	NUM
admet-2268	395	1	%	%	NOUN
admet-2268	395	2	release	release	NOUN
admet-2268	395	3	of	of	ADP
admet-2268	395	4	berberine	berberine	NOUN
admet-2268	395	5	hcl	hcl	PROPN
admet-2268	395	6	and	and	CCONJ
admet-2268	395	7	diacerein	diacerein	ADJ
admet-2268	395	8	,	,	PUNCT
admet-2268	395	9	respectively	respectively	ADV
admet-2268	395	10	,	,	PUNCT
admet-2268	395	11	after	after	ADP
admet-2268	395	12	24	24	NUM
admet-2268	395	13	h	h	NOUN
admet-2268	395	14	)	)	PUNCT
admet-2268	395	15	,	,	PUNCT
admet-2268	395	16	which	which	PRON
admet-2268	395	17	makes	make	VERB
admet-2268	395	18	them	they	PRON
admet-2268	395	19	most	most	ADV
admet-2268	395	20	suitable	suitable	ADJ
admet-2268	395	21	for	for	ADP
admet-2268	395	22	skin	skin	NOUN
admet-2268	395	23	penetration	penetration	NOUN
admet-2268	395	24	.	.	PUNCT
admet-2268	396	1	the	the	DET
admet-2268	396	2	nonlinear	nonlinear	ADJ
admet-2268	396	3	quadratic	quadratic	ADJ
admet-2268	396	4	polynomial	polynomial	ADJ
admet-2268	396	5	model	model	NOUN
admet-2268	396	6	indicated	indicate	VERB
admet-2268	396	7	the	the	DET
admet-2268	396	8	validity	validity	NOUN
admet-2268	396	9	of	of	ADP
admet-2268	396	10	the	the	DET
admet-2268	396	11	developed	develop	VERB
admet-2268	396	12	mathematical	mathematical	ADJ
admet-2268	396	13	model	model	NOUN
admet-2268	396	14	,	,	PUNCT
admet-2268	396	15	which	which	PRON
admet-2268	396	16	can	can	AUX
admet-2268	396	17	be	be	AUX
admet-2268	396	18	used	use	VERB
admet-2268	396	19	to	to	PART
admet-2268	396	20	produce	produce	VERB
admet-2268	396	21	dual	dual	ADJ
admet-2268	396	22	delivery	delivery	NOUN
admet-2268	396	23	transferosomes	transferosome	NOUN
admet-2268	396	24	with	with	ADP
admet-2268	396	25	desired	desire	VERB
admet-2268	396	26	properties	property	NOUN
admet-2268	396	27	.	.	PUNCT
admet-2268	397	1	the	the	DET
admet-2268	397	2	transdermal	transdermal	ADJ
admet-2268	397	3	flux	flux	NOUN
admet-2268	397	4	of	of	ADP
admet-2268	397	5	the	the	DET
admet-2268	397	6	optimized	optimize	VERB
admet-2268	397	7	formulation	formulation	NOUN
admet-2268	397	8	was	be	AUX
admet-2268	397	9	0.0224	0.0224	NUM
admet-2268	397	10	µg	µg	ADV
admet-2268	397	11	cm-2	cm-2	NOUN
admet-2268	397	12	h-1	h-1	X
admet-2268	397	13	(	(	PUNCT
admet-2268	397	14	permeation	permeation	NOUN
admet-2268	397	15	coefficient	coefficient	NOUN
admet-2268	397	16	of	of	ADP
admet-2268	397	17	2.24	2.24	NUM
admet-2268	397	18	cm	cm	NOUN
admet-2268	397	19	h-1	h-1	NOUN
admet-2268	397	20	)	)	PUNCT
admet-2268	397	21	and	and	CCONJ
admet-2268	397	22	0.0462	0.0462	NUM
admet-2268	397	23	µg	µg	ADV
admet-2268	397	24	cm-2	cm-2	NOUN
admet-2268	397	25	h-1	h-1	X
admet-2268	397	26	(	(	PUNCT
admet-2268	397	27	permeation	permeation	NOUN
admet-2268	397	28	coefficient	coefficient	NOUN
admet-2268	397	29	of	of	ADP
admet-2268	397	30	4.62	4.62	NUM
admet-2268	397	31	cm	cm	NOUN
admet-2268	397	32	h-1	h-1	NOUN
admet-2268	397	33	)	)	PUNCT
admet-2268	397	34	,	,	PUNCT
admet-2268	397	35	respectively	respectively	ADV
admet-2268	397	36	,	,	PUNCT
admet-2268	397	37	for	for	ADP
admet-2268	397	38	berberine	berberine	NOUN
admet-2268	397	39	hcl	hcl	PROPN
admet-2268	397	40	and	and	CCONJ
admet-2268	397	41	diacerein	diacerein	ADJ
admet-2268	397	42	.	.	PUNCT
admet-2268	398	1	raman	raman	VERB
admet-2268	398	2	analysis	analysis	NOUN
admet-2268	398	3	of	of	ADP
admet-2268	398	4	treated	treat	VERB
admet-2268	398	5	pig	pig	NOUN
admet-2268	398	6	ear	ear	NOUN
admet-2268	398	7	skin	skin	NOUN
admet-2268	398	8	revealed	reveal	VERB
admet-2268	398	9	that	that	SCONJ
admet-2268	398	10	the	the	DET
admet-2268	398	11	transferosomes	transferosome	NOUN
admet-2268	398	12	permeated	permeate	VERB
admet-2268	398	13	the	the	DET
admet-2268	398	14	skin	skin	NOUN
admet-2268	398	15	.	.	PUNCT
admet-2268	399	1	no	no	DET
admet-2268	399	2	change	change	NOUN
admet-2268	399	3	in	in	ADP
admet-2268	399	4	the	the	DET
admet-2268	399	5	skin	skin	NOUN
admet-2268	399	6	condition	condition	NOUN
admet-2268	399	7	or	or	CCONJ
admet-2268	399	8	irritation	irritation	NOUN
admet-2268	399	9	was	be	AUX
admet-2268	399	10	observed	observe	VERB
admet-2268	399	11	in	in	ADP
admet-2268	399	12	balb	balb	ADJ
admet-2268	399	13	/	/	SYM
admet-2268	399	14	c	c	NOUN
admet-2268	399	15	mice	mouse	NOUN
admet-2268	399	16	.	.	PUNCT
admet-2268	400	1	the	the	DET
admet-2268	400	2	formulation	formulation	NOUN
admet-2268	400	3	was	be	AUX
admet-2268	400	4	found	find	VERB
admet-2268	400	5	to	to	PART
admet-2268	400	6	be	be	AUX
admet-2268	400	7	stable	stable	ADJ
admet-2268	400	8	at	at	ADP
admet-2268	400	9	4	4	NUM
admet-2268	400	10	and	and	CCONJ
admet-2268	400	11	25±2	25±2	NUM
admet-2268	400	12	°	°	ADJ
admet-2268	400	13	c/60±5	c/60±5	ADJ
admet-2268	400	14	%	%	NOUN
admet-2268	400	15	rh	rh	NOUN
admet-2268	400	16	for	for	ADP
admet-2268	400	17	3	3	NUM
admet-2268	400	18	months	month	NOUN
admet-2268	400	19	.	.	PUNCT
admet-2268	401	1	the	the	DET
admet-2268	401	2	preliminary	preliminary	ADJ
admet-2268	401	3	results	result	NOUN
admet-2268	401	4	of	of	ADP
admet-2268	401	5	this	this	DET
admet-2268	401	6	study	study	NOUN
admet-2268	401	7	suggest	suggest	VERB
admet-2268	401	8	that	that	SCONJ
admet-2268	401	9	the	the	DET
admet-2268	401	10	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2268	401	11	and	and	CCONJ
admet-2268	401	12	sodium	sodium	NOUN
admet-2268	401	13	deoxycholate	deoxycholate	NOUN
admet-2268	401	14	-	-	PUNCT
admet-2268	401	15	based	base	VERB
admet-2268	401	16	transferosomes	transferosome	NOUN
admet-2268	401	17	can	can	AUX
admet-2268	401	18	open	open	VERB
admet-2268	401	19	a	a	DET
admet-2268	401	20	new	new	ADJ
admet-2268	401	21	avenue	avenue	NOUN
admet-2268	401	22	for	for	ADP
admet-2268	401	23	potential	potential	ADJ
admet-2268	401	24	topical	topical	ADJ
admet-2268	401	25	co	co	NOUN
admet-2268	401	26	-	-	NOUN
admet-2268	401	27	delivery	delivery	NOUN
admet-2268	401	28	of	of	ADP
admet-2268	401	29	berberine	berberine	NOUN
admet-2268	401	30	hcl	hcl	PROPN
admet-2268	401	31	and	and	CCONJ
admet-2268	401	32	diacerein	diacerein	ADJ
admet-2268	401	33	for	for	ADP
admet-2268	401	34	psoriasis	psoriasis	NOUN
admet-2268	401	35	therapy	therapy	NOUN
admet-2268	401	36	.	.	PUNCT
admet-2268	402	1	r	r	NOUN
admet-2268	402	2	el	el	PROPN
admet-2268	402	3	at	at	ADP
admet-2268	402	4	ic	ic	PROPN
admet-2268	402	5	e	e	PROPN
admet-2268	402	6	fr	fr	PROPN
admet-2268	402	7	eq	eq	ADP
admet-2268	402	8	u	u	PROPN
admet-2268	402	9	en	en	ADP
admet-2268	402	10	cy	cy	PROPN
admet-2268	402	11	r	r	PROPN
admet-2268	402	12	el	el	PROPN
admet-2268	402	13	at	at	ADP
admet-2268	402	14	ic	ic	PROPN
admet-2268	402	15	e	e	PROPN
admet-2268	402	16	fr	fr	PROPN
admet-2268	402	17	eq	eq	ADP
admet-2268	402	18	u	u	PROPN
admet-2268	402	19	en	en	ADP
admet-2268	402	20	cy	cy	PROPN
admet-2268	402	21	in	in	ADP
admet-2268	402	22	te	te	PROPN
admet-2268	402	23	n	n	CCONJ
admet-2268	402	24	si	si	INTJ
admet-2268	402	25	ty	ty	INTJ
admet-2268	402	26	,	,	PUNCT
admet-2268	402	27	a	a	DET
admet-2268	402	28	.u	.u	NOUN
admet-2268	402	29	.	.	PUNCT
admet-2268	403	1	in	in	ADP
admet-2268	403	2	te	te	PROPN
admet-2268	403	3	n	n	CCONJ
admet-2268	403	4	si	si	INTJ
admet-2268	403	5	ty	ty	INTJ
admet-2268	403	6	,	,	PUNCT
admet-2268	403	7	a	a	DET
admet-2268	403	8	.u	.u	NOUN
admet-2268	403	9	.	.	PUNCT
admet-2268	404	1	(	(	PUNCT
admet-2268	404	2	e	e	X
admet-2268	404	3	)	)	PUNCT
admet-2268	404	4	(	(	PUNCT
admet-2268	404	5	f	f	X
admet-2268	404	6	)	)	PUNCT
admet-2268	404	7	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	PROPN
admet-2268	404	8	s.	s.	PROPN
admet-2268	404	9	singh	singh	PROPN
admet-2268	404	10	and	and	CCONJ
admet-2268	404	11	r.	r.	PROPN
admet-2268	404	12	awasthi	awasthi	PROPN
admet-2268	404	13	admet	admet	PROPN
admet-2268	404	14	&	&	CCONJ
admet-2268	404	15	dmpk	dmpk	PROPN
admet-2268	404	16	12(3	12(3	PROPN
admet-2268	404	17	)	)	PUNCT
admet-2268	404	18	(	(	PUNCT
admet-2268	404	19	2024	2024	NUM
admet-2268	404	20	)	)	PUNCT
admet-2268	404	21	553	553	NUM
admet-2268	404	22	-	-	SYM
admet-2268	404	23	580	580	NUM
admet-2268	404	24	576	576	NUM
admet-2268	404	25	acknowledgements	acknowledgement	NOUN
admet-2268	404	26	:	:	PUNCT
admet-2268	404	27	the	the	DET
admet-2268	404	28	authors	author	NOUN
admet-2268	404	29	are	be	AUX
admet-2268	404	30	grateful	grateful	ADJ
admet-2268	404	31	to	to	ADP
admet-2268	404	32	upes	upe	NOUN
admet-2268	404	33	,	,	PUNCT
admet-2268	404	34	dehradun	dehradun	PROPN
admet-2268	404	35	,	,	PUNCT
admet-2268	404	36	india	india	PROPN
admet-2268	404	37	for	for	ADP
admet-2268	404	38	providing	provide	VERB
admet-2268	404	39	necessary	necessary	ADJ
admet-2268	404	40	facilities	facility	NOUN
admet-2268	404	41	to	to	PART
admet-2268	404	42	complete	complete	VERB
admet-2268	404	43	research	research	NOUN
admet-2268	404	44	work	work	NOUN
admet-2268	404	45	successfully	successfully	ADV
admet-2268	404	46	.	.	PUNCT
admet-2268	405	1	conflict	conflict	NOUN
admet-2268	405	2	of	of	ADP
admet-2268	405	3	interest	interest	NOUN
admet-2268	405	4	:	:	PUNCT
admet-2268	405	5	the	the	DET
admet-2268	405	6	authors	author	NOUN
admet-2268	405	7	declared	declare	VERB
admet-2268	405	8	that	that	SCONJ
admet-2268	405	9	there	there	PRON
admet-2268	405	10	are	be	VERB
admet-2268	405	11	no	no	DET
admet-2268	405	12	conflicts	conflict	NOUN
admet-2268	405	13	of	of	ADP
admet-2268	405	14	interest	interest	NOUN
admet-2268	405	15	.	.	PUNCT
admet-2268	406	1	references	reference	NOUN
admet-2268	406	2	[	[	X
admet-2268	406	3	1	1	NUM
admet-2268	406	4	]	]	PUNCT
admet-2268	406	5	m.	m.	NOUN
admet-2268	406	6	pradhan	pradhan	PROPN
admet-2268	406	7	,	,	PUNCT
admet-2268	406	8	a.	a.	NOUN
admet-2268	406	9	alexander	alexander	PROPN
admet-2268	406	10	,	,	PUNCT
admet-2268	406	11	m.r	m.r	PROPN
admet-2268	406	12	.	.	PROPN
admet-2268	406	13	singh	singh	PROPN
admet-2268	406	14	,	,	PUNCT
admet-2268	406	15	d.	d.	PROPN
admet-2268	406	16	singh	singh	PROPN
admet-2268	406	17	,	,	PUNCT
admet-2268	406	18	s.	s.	PROPN
admet-2268	406	19	saraf	saraf	PROPN
admet-2268	406	20	,	,	PUNCT
admet-2268	406	21	s.	s.	PROPN
admet-2268	406	22	saraf	saraf	PROPN
admet-2268	406	23	,	,	PUNCT
admet-2268	406	24	ajazuddin	ajazuddin	ADJ
admet-2268	406	25	.	.	PUNCT
admet-2268	407	1	understanding	understand	VERB
admet-2268	407	2	the	the	DET
admet-2268	407	3	prospective	prospective	ADJ
admet-2268	407	4	of	of	ADP
admet-2268	407	5	nano	nano	NOUN
admet-2268	407	6	-	-	PUNCT
admet-2268	407	7	formulations	formulation	NOUN
admet-2268	407	8	towards	towards	ADP
admet-2268	407	9	the	the	DET
admet-2268	407	10	treatment	treatment	NOUN
admet-2268	407	11	of	of	ADP
admet-2268	407	12	psoriasis	psoriasis	NOUN
admet-2268	407	13	.	.	PUNCT
admet-2268	408	1	biomedicine	biomedicine	NOUN
admet-2268	408	2	&	&	CCONJ
admet-2268	408	3	pharmacotherapy	pharmacotherapy	NOUN
admet-2268	408	4	107	107	NUM
admet-2268	408	5	(	(	PUNCT
admet-2268	408	6	2018	2018	NUM
admet-2268	408	7	)	)	PUNCT
admet-2268	408	8	447	447	NUM
admet-2268	408	9	-	-	SYM
admet-2268	408	10	463	463	NUM
admet-2268	408	11	.	.	PUNCT
admet-2268	408	12	https://doi.org/10.1016/j.biopha.2018.07.156	https://doi.org/10.1016/j.biopha.2018.07.156	PROPN
admet-2268	408	13	.	.	PUNCT
admet-2268	409	1	[	[	X
admet-2268	409	2	2	2	X
admet-2268	409	3	]	]	PUNCT
admet-2268	409	4	s.	s.	PROPN
admet-2268	409	5	singh	singh	PROPN
admet-2268	409	6	,	,	PUNCT
admet-2268	409	7	r.	r.	PROPN
admet-2268	409	8	awasthi	awasthi	PROPN
admet-2268	409	9	.	.	PUNCT
admet-2268	410	1	breakthroughs	breakthrough	NOUN
admet-2268	410	2	and	and	CCONJ
admet-2268	410	3	bottlenecks	bottleneck	NOUN
admet-2268	410	4	of	of	ADP
admet-2268	410	5	psoriasis	psoriasis	NOUN
admet-2268	410	6	therapy	therapy	NOUN
admet-2268	410	7	:	:	PUNCT
admet-2268	410	8	emerging	emerge	VERB
admet-2268	410	9	trends	trend	NOUN
admet-2268	410	10	and	and	CCONJ
admet-2268	410	11	advances	advance	NOUN
admet-2268	410	12	in	in	ADP
admet-2268	410	13	lipid	lipid	NOUN
admet-2268	410	14	based	base	VERB
admet-2268	410	15	nano	nano	NOUN
admet-2268	410	16	-	-	PUNCT
admet-2268	410	17	drug	drug	NOUN
admet-2268	410	18	delivery	delivery	NOUN
admet-2268	410	19	platforms	platform	NOUN
admet-2268	410	20	for	for	ADP
admet-2268	410	21	dermal	dermal	NOUN
admet-2268	410	22	and	and	CCONJ
admet-2268	410	23	transdermal	transdermal	ADJ
admet-2268	410	24	drug	drug	NOUN
admet-2268	410	25	delivery	delivery	NOUN
admet-2268	410	26	.	.	PUNCT
admet-2268	411	1	journal	journal	NOUN
admet-2268	411	2	of	of	ADP
admet-2268	411	3	drug	drug	NOUN
admet-2268	411	4	delivery	delivery	NOUN
admet-2268	411	5	science	science	NOUN
admet-2268	411	6	and	and	CCONJ
admet-2268	411	7	technology	technology	NOUN
admet-2268	411	8	84	84	NUM
admet-2268	411	9	(	(	PUNCT
admet-2268	411	10	2023	2023	NUM
admet-2268	411	11	)	)	PUNCT
admet-2268	411	12	104548	104548	NUM
admet-2268	411	13	.	.	PUNCT
admet-2268	412	1	https://doi.org/10.1016/j.jddst.2023.104548	https://doi.org/10.1016/j.jddst.2023.104548	ADJ
admet-2268	412	2	.	.	PUNCT
admet-2268	413	1	[	[	X
admet-2268	413	2	3	3	X
admet-2268	413	3	]	]	X
admet-2268	413	4	s.	s.	PROPN
admet-2268	413	5	jindal	jindal	PROPN
admet-2268	413	6	,	,	PUNCT
admet-2268	413	7	r.	r.	PROPN
admet-2268	413	8	awasthi	awasthi	PROPN
admet-2268	413	9	,	,	PUNCT
admet-2268	413	10	d.	d.	PROPN
admet-2268	413	11	singare	singare	PROPN
admet-2268	413	12	,	,	PUNCT
admet-2268	413	13	g.t	g.t	PROPN
admet-2268	413	14	.	.	PROPN
admet-2268	413	15	kulkarni	kulkarni	PROPN
admet-2268	413	16	.	.	PUNCT
admet-2268	414	1	preparation	preparation	NOUN
admet-2268	414	2	and	and	CCONJ
admet-2268	414	3	in	in	ADP
admet-2268	414	4	vitro	vitro	X
admet-2268	414	5	evaluation	evaluation	NOUN
admet-2268	414	6	of	of	ADP
admet-2268	414	7	tacrolimus	tacrolimus	PROPN
admet-2268	414	8	loaded	load	VERB
admet-2268	414	9	liposomal	liposomal	ADJ
admet-2268	414	10	vesicles	vesicle	NOUN
admet-2268	414	11	by	by	ADP
admet-2268	414	12	two	two	NUM
admet-2268	414	13	methods	method	NOUN
admet-2268	414	14	:	:	PUNCT
admet-2268	414	15	a	a	DET
admet-2268	414	16	comparative	comparative	ADJ
admet-2268	414	17	study	study	NOUN
admet-2268	414	18	.	.	PUNCT
admet-2268	415	1	journal	journal	PROPN
admet-2268	415	2	of	of	ADP
admet-2268	415	3	research	research	NOUN
admet-2268	415	4	in	in	ADP
admet-2268	415	5	pharmacy	pharmacy	NOUN
admet-2268	415	6	25	25	NUM
admet-2268	415	7	(	(	PUNCT
admet-2268	415	8	2021	2021	NUM
admet-2268	415	9	)	)	PUNCT
admet-2268	415	10	34	34	NUM
admet-2268	415	11	-	-	SYM
admet-2268	415	12	41	41	NUM
admet-2268	415	13	.	.	PUNCT
admet-2268	416	1	https://doi.org/10.35333/jrp.2021.292	https://doi.org/10.35333/jrp.2021.292	NOUN
admet-2268	416	2	.	.	PUNCT
admet-2268	417	1	[	[	X
admet-2268	417	2	4	4	X
admet-2268	417	3	]	]	PUNCT
admet-2268	417	4	s.	s.	PROPN
admet-2268	417	5	parab	parab	PROPN
admet-2268	417	6	,	,	PUNCT
admet-2268	417	7	g.	g.	PROPN
admet-2268	417	8	doshi	doshi	PROPN
admet-2268	417	9	.	.	PUNCT
admet-2268	418	1	an	an	DET
admet-2268	418	2	update	update	NOUN
admet-2268	418	3	on	on	ADP
admet-2268	418	4	emerging	emerge	VERB
admet-2268	418	5	immunological	immunological	ADJ
admet-2268	418	6	targets	target	NOUN
admet-2268	418	7	and	and	CCONJ
admet-2268	418	8	their	their	PRON
admet-2268	418	9	inhibitors	inhibitor	NOUN
admet-2268	418	10	in	in	ADP
admet-2268	418	11	the	the	DET
admet-2268	418	12	treatment	treatment	NOUN
admet-2268	418	13	of	of	ADP
admet-2268	418	14	psoriasis	psoriasis	NOUN
admet-2268	418	15	.	.	PUNCT
admet-2268	419	1	international	international	ADJ
admet-2268	419	2	immunopharmacology	immunopharmacology	NOUN
admet-2268	419	3	113	113	NUM
admet-2268	419	4	(	(	PUNCT
admet-2268	419	5	2022	2022	NUM
admet-2268	419	6	)	)	PUNCT
admet-2268	419	7	109341	109341	NUM
admet-2268	419	8	.	.	PUNCT
admet-2268	420	1	https://doi.org/10.1016/j.intimp.2022.109341	https://doi.org/10.1016/j.intimp.2022.109341	NOUN
admet-2268	420	2	.	.	PUNCT
admet-2268	421	1	[	[	X
admet-2268	421	2	5	5	NUM
admet-2268	421	3	]	]	PUNCT
admet-2268	421	4	a.	a.	NOUN
admet-2268	421	5	rendon	rendon	PROPN
admet-2268	421	6	,	,	PUNCT
admet-2268	421	7	k.	k.	PROPN
admet-2268	421	8	schäkel	schäkel	PROPN
admet-2268	421	9	.	.	PUNCT
admet-2268	422	1	psoriasis	psoriasis	NOUN
admet-2268	422	2	pathogenesis	pathogenesis	NOUN
admet-2268	422	3	and	and	CCONJ
admet-2268	422	4	treatment	treatment	NOUN
admet-2268	422	5	.	.	PUNCT
admet-2268	423	1	international	international	ADJ
admet-2268	423	2	journal	journal	NOUN
admet-2268	423	3	of	of	ADP
admet-2268	423	4	molecular	molecular	ADJ
admet-2268	423	5	sciences	science	NOUN
admet-2268	423	6	20	20	NUM
admet-2268	423	7	(	(	PUNCT
admet-2268	423	8	2019	2019	NUM
admet-2268	423	9	)	)	PUNCT
admet-2268	423	10	1475	1475	NUM
admet-2268	423	11	.	.	PUNCT
admet-2268	424	1	https://doi.org/10.3390/ijms20061475	https://doi.org/10.3390/ijms20061475	PROPN
admet-2268	424	2	.	.	PUNCT
admet-2268	425	1	[	[	X
admet-2268	425	2	6	6	NUM
admet-2268	425	3	]	]	PUNCT
admet-2268	425	4	f.	f.	PROPN
admet-2268	425	5	mascarenhas	mascarenhas	PROPN
admet-2268	425	6	-	-	PUNCT
admet-2268	425	7	melo	melo	PROPN
admet-2268	425	8	,	,	PUNCT
admet-2268	425	9	a.	a.	NOUN
admet-2268	425	10	carvalho	carvalho	PROPN
admet-2268	425	11	,	,	PUNCT
admet-2268	425	12	m.b.s	m.b.s	PROPN
admet-2268	425	13	.	.	PUNCT
admet-2268	425	14	gonçalves	gonçalves	PROPN
admet-2268	425	15	,	,	PUNCT
admet-2268	425	16	a.c	a.c	PROPN
admet-2268	425	17	.	.	PROPN
admet-2268	425	18	paiva	paiva	NOUN
admet-2268	425	19	-	-	PUNCT
admet-2268	425	20	santos	santos	PROPN
admet-2268	425	21	,	,	PUNCT
admet-2268	425	22	f.	f.	PROPN
admet-2268	425	23	veiga	veiga	PROPN
admet-2268	425	24	.	.	PUNCT
admet-2268	426	1	nanocarriers	nanocarrier	NOUN
admet-2268	426	2	for	for	ADP
admet-2268	426	3	the	the	DET
admet-2268	426	4	topical	topical	ADJ
admet-2268	426	5	treatment	treatment	NOUN
admet-2268	426	6	of	of	ADP
admet-2268	426	7	psoriasis	psoriasis	NOUN
admet-2268	426	8	pathophysiology	pathophysiology	NOUN
admet-2268	426	9	,	,	PUNCT
admet-2268	426	10	conventional	conventional	ADJ
admet-2268	426	11	treatments	treatment	NOUN
admet-2268	426	12	,	,	PUNCT
admet-2268	426	13	nanotechnology	nanotechnology	NOUN
admet-2268	426	14	,	,	PUNCT
admet-2268	426	15	regulatory	regulatory	ADJ
admet-2268	426	16	and	and	CCONJ
admet-2268	426	17	toxicology	toxicology	NOUN
admet-2268	426	18	.	.	PUNCT
admet-2268	427	1	european	european	PROPN
admet-2268	427	2	journal	journal	PROPN
admet-2268	427	3	of	of	ADP
admet-2268	427	4	pharmaceutics	pharmaceutic	NOUN
admet-2268	427	5	and	and	CCONJ
admet-2268	427	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2268	427	7	176	176	NUM
admet-2268	427	8	(	(	PUNCT
admet-2268	427	9	2022	2022	NUM
admet-2268	427	10	)	)	PUNCT
admet-2268	427	11	95107	95107	NUM
admet-2268	427	12	https://doi.org/10.1016/j.ejpb.2022.05.012	https://doi.org/10.1016/j.ejpb.2022.05.012	NOUN
admet-2268	427	13	.	.	PUNCT
admet-2268	428	1	[	[	X
admet-2268	428	2	7	7	X
admet-2268	428	3	]	]	X
admet-2268	428	4	v.k	v.k	PROPN
admet-2268	428	5	.	.	PROPN
admet-2268	428	6	rapalli	rapalli	PROPN
admet-2268	428	7	,	,	PUNCT
admet-2268	428	8	g.	g.	PROPN
admet-2268	428	9	singhvi	singhvi	PROPN
admet-2268	428	10	,	,	PUNCT
admet-2268	428	11	s.k	s.k	PROPN
admet-2268	428	12	.	.	PROPN
admet-2268	428	13	dubey	dubey	PROPN
admet-2268	428	14	,	,	PUNCT
admet-2268	428	15	g.	g.	PROPN
admet-2268	428	16	gupta	gupta	PROPN
admet-2268	428	17	,	,	PUNCT
admet-2268	428	18	d.k	d.k	PROPN
admet-2268	428	19	.	.	PROPN
admet-2268	428	20	chellappan	chellappan	PROPN
admet-2268	428	21	,	,	PUNCT
admet-2268	428	22	k.	k.	PROPN
admet-2268	428	23	dua	dua	PROPN
admet-2268	428	24	.	.	PUNCT
admet-2268	428	25	emerging	emerge	VERB
admet-2268	428	26	landscape	landscape	NOUN
admet-2268	428	27	in	in	ADP
admet-2268	428	28	psoriasis	psoriasis	NOUN
admet-2268	428	29	management	management	NOUN
admet-2268	428	30	:	:	PUNCT
admet-2268	428	31	from	from	ADP
admet-2268	428	32	topical	topical	ADJ
admet-2268	428	33	application	application	NOUN
admet-2268	428	34	to	to	ADP
admet-2268	428	35	targeting	target	VERB
admet-2268	428	36	biomolecules	biomolecule	NOUN
admet-2268	428	37	.	.	PUNCT
admet-2268	429	1	biomedicine	biomedicine	NOUN
admet-2268	429	2	and	and	CCONJ
admet-2268	429	3	pharmacotherapy	pharmacotherapy	NOUN
admet-2268	429	4	106	106	NUM
admet-2268	429	5	(	(	PUNCT
admet-2268	429	6	2018	2018	NUM
admet-2268	429	7	)	)	PUNCT
admet-2268	429	8	707	707	NUM
admet-2268	429	9	-	-	SYM
admet-2268	429	10	713	713	NUM
admet-2268	429	11	.	.	PUNCT
admet-2268	430	1	https://doi.org/10.1016/j.biopha.2018.06.136	https://doi.org/10.1016/j.biopha.2018.06.136	NOUN
admet-2268	430	2	.	.	PUNCT
admet-2268	431	1	[	[	X
admet-2268	431	2	8	8	NUM
admet-2268	431	3	]	]	PUNCT
admet-2268	431	4	k.	k.	PROPN
admet-2268	431	5	yadav	yadav	PROPN
admet-2268	431	6	,	,	PUNCT
admet-2268	431	7	k.k	k.k	PROPN
admet-2268	431	8	.	.	PROPN
admet-2268	431	9	sahu	sahu	PROPN
admet-2268	431	10	,	,	PUNCT
admet-2268	431	11	r.	r.	PROPN
admet-2268	431	12	yadav	yadav	PROPN
admet-2268	431	13	,	,	PUNCT
admet-2268	431	14	w.	w.	PROPN
admet-2268	431	15	raza	raza	PROPN
admet-2268	431	16	,	,	PUNCT
admet-2268	431	17	s.	s.	PROPN
admet-2268	431	18	minz	minz	PROPN
admet-2268	431	19	,	,	PUNCT
admet-2268	431	20	m.r	m.r	PROPN
admet-2268	431	21	.	.	PROPN
admet-2268	431	22	singh	singh	PROPN
admet-2268	431	23	,	,	PUNCT
admet-2268	431	24	d.	d.	PROPN
admet-2268	431	25	singh	singh	PROPN
admet-2268	431	26	,	,	PUNCT
admet-2268	431	27	m.	m.	NOUN
admet-2268	431	28	pradhan	pradhan	PROPN
admet-2268	431	29	.	.	PUNCT
admet-2268	432	1	a	a	DET
admet-2268	432	2	complex	complex	ADJ
admet-2268	432	3	molecular	molecular	ADJ
admet-2268	432	4	landscape	landscape	NOUN
admet-2268	432	5	to	to	ADP
admet-2268	432	6	drug	drug	NOUN
admet-2268	432	7	delivery	delivery	NOUN
admet-2268	432	8	concept	concept	NOUN
admet-2268	432	9	for	for	ADP
admet-2268	432	10	achieving	achieve	VERB
admet-2268	432	11	precise	precise	ADJ
admet-2268	432	12	therapy	therapy	NOUN
admet-2268	432	13	in	in	ADP
admet-2268	432	14	psoriasis	psoriasis	NOUN
admet-2268	432	15	.	.	PUNCT
admet-2268	433	1	medicine	medicine	NOUN
admet-2268	433	2	in	in	ADP
admet-2268	433	3	drug	drug	NOUN
admet-2268	433	4	discovery	discovery	PROPN
admet-2268	433	5	22	22	NUM
admet-2268	433	6	(	(	PUNCT
admet-2268	433	7	2024	2024	NUM
admet-2268	433	8	)	)	PUNCT
admet-2268	433	9	100183	100183	NUM
admet-2268	433	10	.	.	PUNCT
admet-2268	434	1	https://doi.org/10.1016/j.medidd.2024.100183	https://doi.org/10.1016/j.medidd.2024.100183	PROPN
admet-2268	434	2	.	.	PUNCT
admet-2268	435	1	[	[	X
admet-2268	435	2	9	9	NUM
admet-2268	435	3	]	]	X
admet-2268	435	4	r.	r.	PROPN
admet-2268	435	5	bahuguna	bahuguna	PROPN
admet-2268	435	6	,	,	PUNCT
admet-2268	435	7	r.	r.	PROPN
admet-2268	435	8	awasthi	awasthi	PROPN
admet-2268	435	9	.	.	PUNCT
admet-2268	436	1	unlocking	unlock	VERB
admet-2268	436	2	new	new	ADJ
admet-2268	436	3	dimensions	dimension	NOUN
admet-2268	436	4	in	in	ADP
admet-2268	436	5	rheumatoid	rheumatoid	NOUN
admet-2268	436	6	arthritis	arthritis	NOUN
admet-2268	436	7	therapy	therapy	NOUN
admet-2268	436	8	:	:	PUNCT
admet-2268	436	9	harnessing	harness	VERB
admet-2268	436	10	the	the	DET
admet-2268	436	11	power	power	NOUN
admet-2268	436	12	of	of	ADP
admet-2268	436	13	lipid	lipid	NOUN
admet-2268	436	14	based	base	VERB
admet-2268	436	15	vesicles	vesicle	NOUN
admet-2268	436	16	beyond	beyond	ADP
admet-2268	436	17	traditional	traditional	ADJ
admet-2268	436	18	therapies	therapy	NOUN
admet-2268	436	19	.	.	PUNCT
admet-2268	437	1	journal	journal	PROPN
admet-2268	437	2	of	of	ADP
admet-2268	437	3	drug	drug	NOUN
admet-2268	437	4	delivery	delivery	NOUN
admet-2268	437	5	science	science	NOUN
admet-2268	437	6	and	and	CCONJ
admet-2268	437	7	technology	technology	NOUN
admet-2268	437	8	89	89	NUM
admet-2268	437	9	(	(	PUNCT
admet-2268	437	10	2023	2023	NUM
admet-2268	437	11	)	)	PUNCT
admet-2268	437	12	105106	105106	NUM
admet-2268	437	13	.	.	PUNCT
admet-2268	438	1	https://doi.org/10.1016/j.jddst.2023.105106	https://doi.org/10.1016/j.jddst.2023.105106	PROPN
admet-2268	438	2	.	.	PUNCT
admet-2268	439	1	[	[	X
admet-2268	439	2	10	10	NUM
admet-2268	439	3	]	]	PUNCT
admet-2268	439	4	s.a.t	s.a.t	NOUN
admet-2268	439	5	.	.	PUNCT
admet-2268	440	1	opatha	opatha	PROPN
admet-2268	440	2	,	,	PUNCT
admet-2268	440	3	v.	v.	PROPN
admet-2268	440	4	titapiwatanakun	titapiwatanakun	PROPN
admet-2268	440	5	,	,	PUNCT
admet-2268	440	6	r.	r.	PROPN
admet-2268	440	7	chutoprapat	chutoprapat	PROPN
admet-2268	440	8	.	.	PUNCT
admet-2268	441	1	transfersomes	transfersome	NOUN
admet-2268	441	2	:	:	PUNCT
admet-2268	441	3	a	a	DET
admet-2268	441	4	promising	promising	ADJ
admet-2268	441	5	nanoencapsulation	nanoencapsulation	NOUN
admet-2268	441	6	technique	technique	NOUN
admet-2268	441	7	for	for	ADP
admet-2268	441	8	transdermal	transdermal	ADJ
admet-2268	441	9	drug	drug	NOUN
admet-2268	441	10	delivery	delivery	NOUN
admet-2268	441	11	.	.	PUNCT
admet-2268	442	1	pharmaceutics	pharmaceutic	NOUN
admet-2268	442	2	12	12	NUM
admet-2268	442	3	(	(	PUNCT
admet-2268	442	4	2020	2020	NUM
admet-2268	442	5	)	)	PUNCT
admet-2268	442	6	855	855	NUM
admet-2268	442	7	.	.	PUNCT
admet-2268	442	8	https://doi.org/10.3390/pharmaceutics12090855	https://doi.org/10.3390/pharmaceutics12090855	PROPN
admet-2268	442	9	.	.	PUNCT
admet-2268	443	1	[	[	X
admet-2268	443	2	11	11	NUM
admet-2268	443	3	]	]	PUNCT
admet-2268	443	4	r.	r.	PROPN
admet-2268	443	5	fernández	fernández	PROPN
admet-2268	443	6	-	-	PUNCT
admet-2268	443	7	garcía	garcía	ADJ
admet-2268	443	8	,	,	PUNCT
admet-2268	443	9	a.	a.	NOUN
admet-2268	443	10	lalatsa	lalatsa	PROPN
admet-2268	443	11	,	,	PUNCT
admet-2268	443	12	l.	l.	PROPN
admet-2268	443	13	statts	statts	PROPN
admet-2268	443	14	,	,	PUNCT
admet-2268	443	15	f.	f.	PROPN
admet-2268	443	16	bolás	bolás	PROPN
admet-2268	443	17	-	-	PUNCT
admet-2268	443	18	fernández	fernández	PROPN
admet-2268	443	19	,	,	PUNCT
admet-2268	443	20	m.p	m.p	PROPN
admet-2268	443	21	.	.	PROPN
admet-2268	443	22	ballesteros	ballesteros	PROPN
admet-2268	443	23	,	,	PUNCT
admet-2268	443	24	d.r	d.r	PROPN
admet-2268	443	25	.	.	PROPN
admet-2268	443	26	serrano	serrano	PROPN
admet-2268	443	27	.	.	PUNCT
admet-2268	444	1	transferosomes	transferosome	NOUN
admet-2268	444	2	as	as	ADP
admet-2268	444	3	nanocarriers	nanocarrier	NOUN
admet-2268	444	4	for	for	ADP
admet-2268	444	5	drugs	drug	NOUN
admet-2268	444	6	across	across	ADP
admet-2268	444	7	the	the	DET
admet-2268	444	8	skin	skin	NOUN
admet-2268	444	9	:	:	PUNCT
admet-2268	444	10	quality	quality	NOUN
admet-2268	444	11	by	by	ADP
admet-2268	444	12	design	design	NOUN
admet-2268	444	13	from	from	ADP
admet-2268	444	14	lab	lab	NOUN
admet-2268	444	15	to	to	ADP
admet-2268	444	16	industrial	industrial	ADJ
admet-2268	444	17	scale	scale	NOUN
admet-2268	444	18	.	.	PUNCT
admet-2268	445	1	international	international	ADJ
admet-2268	445	2	journal	journal	PROPN
admet-2268	445	3	of	of	ADP
admet-2268	445	4	pharmaceutics	pharmaceutic	NOUN
admet-2268	445	5	573	573	NUM
admet-2268	445	6	(	(	PUNCT
admet-2268	445	7	2020	2020	NUM
admet-2268	445	8	)	)	PUNCT
admet-2268	445	9	118817	118817	NUM
admet-2268	445	10	https://doi.org/10.1016/j.ijpharm.2019.118817	https://doi.org/10.1016/j.ijpharm.2019.118817	NOUN
admet-2268	445	11	.	.	PUNCT
admet-2268	446	1	[	[	X
admet-2268	446	2	12	12	NUM
admet-2268	446	3	]	]	X
admet-2268	446	4	v.	v.	PROPN
admet-2268	446	5	parkash	parkash	PROPN
admet-2268	446	6	,	,	PUNCT
admet-2268	446	7	s.	s.	PROPN
admet-2268	446	8	maan	maan	PROPN
admet-2268	446	9	,	,	PUNCT
admet-2268	446	10	v.	v.	PROPN
admet-2268	446	11	chaudhary	chaudhary	PROPN
admet-2268	446	12	,	,	PUNCT
admet-2268	446	13	v.	v.	ADP
admet-2268	446	14	jogpal	jogpal	PROPN
admet-2268	446	15	,	,	PUNCT
admet-2268	446	16	g.	g.	PROPN
admet-2268	446	17	mittal	mittal	PROPN
admet-2268	446	18	,	,	PUNCT
admet-2268	446	19	v.	v.	PROPN
admet-2268	446	20	jain	jain	PROPN
admet-2268	446	21	.	.	PUNCT
admet-2268	447	1	implementation	implementation	NOUN
admet-2268	447	2	of	of	ADP
admet-2268	447	3	design	design	NOUN
admet-2268	447	4	of	of	ADP
admet-2268	447	5	experiments	experiment	NOUN
admet-2268	447	6	in	in	ADP
admet-2268	447	7	development	development	NOUN
admet-2268	447	8	and	and	CCONJ
admet-2268	447	9	optimization	optimization	NOUN
admet-2268	447	10	of	of	ADP
admet-2268	447	11	transfersomal	transfersomal	ADJ
admet-2268	447	12	carrier	carrier	NOUN
admet-2268	447	13	system	system	NOUN
admet-2268	447	14	of	of	ADP
admet-2268	447	15	tacrolimus	tacrolimus	NOUN
admet-2268	447	16	for	for	ADP
admet-2268	447	17	the	the	DET
admet-2268	447	18	dermal	dermal	ADJ
admet-2268	447	19	management	management	NOUN
admet-2268	447	20	of	of	ADP
admet-2268	447	21	psoriasis	psoriasis	NOUN
admet-2268	447	22	in	in	ADP
admet-2268	447	23	albino	albino	PROPN
admet-2268	447	24	wistar	wistar	PROPN
admet-2268	447	25	rat	rat	PROPN
admet-2268	447	26	.	.	PROPN
admet-2268	448	1	j	j	PROPN
admet-2268	448	2	bioequiv	bioequiv	PROPN
admet-2268	448	3	availab	availab	PROPN
admet-2268	448	4	10	10	NUM
admet-2268	448	5	(	(	PUNCT
admet-2268	448	6	2018	2018	NUM
admet-2268	448	7	)	)	PUNCT
admet-2268	448	8	98	98	NUM
admet-2268	448	9	-	-	SYM
admet-2268	448	10	105	105	NUM
admet-2268	448	11	.	.	PUNCT
admet-2268	449	1	https://doi.org/10.4172/0975-0851.1000385	https://doi.org/10.4172/0975-0851.1000385	PROPN
admet-2268	449	2	.	.	PUNCT
admet-2268	450	1	[	[	X
admet-2268	450	2	13	13	NUM
admet-2268	450	3	]	]	X
admet-2268	450	4	r.p	r.p	PROPN
admet-2268	450	5	.	.	PROPN
admet-2268	450	6	dhavale	dhavale	PROPN
admet-2268	450	7	,	,	PUNCT
admet-2268	450	8	s.j	s.j	PROPN
admet-2268	450	9	.	.	PROPN
admet-2268	450	10	nadaf	nadaf	PROPN
admet-2268	450	11	,	,	PUNCT
admet-2268	450	12	m.s	m.s	PROPN
admet-2268	450	13	.	.	PROPN
admet-2268	450	14	bhatia	bhatia	PROPN
admet-2268	450	15	.	.	PUNCT
admet-2268	451	1	quantitative	quantitative	ADJ
admet-2268	451	2	structure	structure	NOUN
admet-2268	451	3	property	property	NOUN
admet-2268	451	4	relationship	relationship	NOUN
admet-2268	451	5	assisted	assist	VERB
admet-2268	451	6	development	development	NOUN
admet-2268	451	7	of	of	ADP
admet-2268	451	8	fluocinolone	fluocinolone	PROPN
admet-2268	451	9	acetonide	acetonide	NOUN
admet-2268	451	10	loaded	load	VERB
admet-2268	451	11	transfersomes	transfersome	NOUN
admet-2268	451	12	for	for	ADP
admet-2268	451	13	targeted	target	VERB
admet-2268	451	14	delivery	delivery	NOUN
admet-2268	451	15	.	.	PUNCT
admet-2268	452	1	journal	journal	NOUN
admet-2268	452	2	of	of	ADP
admet-2268	452	3	drug	drug	NOUN
admet-2268	452	4	delivery	delivery	NOUN
admet-2268	452	5	science	science	NOUN
admet-2268	452	6	and	and	CCONJ
admet-2268	452	7	technology	technology	NOUN
admet-2268	452	8	65	65	NUM
admet-2268	452	9	(	(	PUNCT
admet-2268	452	10	2021)102758	2021)102758	NUM
admet-2268	452	11	.	.	PUNCT
admet-2268	453	1	https://doi.org/10.1016/j.jddst.2021.102758	https://doi.org/10.1016/j.jddst.2021.102758	PROPN
admet-2268	453	2	.	.	PUNCT
admet-2268	454	1	https://doi.org/10.1016/j.biopha.2018.07.156	https://doi.org/10.1016/j.biopha.2018.07.156	PROPN
admet-2268	454	2	https://doi.org/10.1016/j.jddst.2023.104548	https://doi.org/10.1016/j.jddst.2023.104548	ADJ
admet-2268	454	3	https://doi.org/10.35333/jrp.2021.292	https://doi.org/10.35333/jrp.2021.292	NOUN
admet-2268	454	4	https://doi.org/10.1016/j.intimp.2022.109341	https://doi.org/10.1016/j.intimp.2022.109341	NOUN
admet-2268	454	5	https://doi.org/10.3390/ijms20061475	https://doi.org/10.3390/ijms20061475	VERB
admet-2268	454	6	https://doi.org/10.1016/j.ejpb.2022.05.012	https://doi.org/10.1016/j.ejpb.2022.05.012	NOUN
admet-2268	454	7	https://doi.org/10.1016/j.biopha.2018.06.136	https://doi.org/10.1016/j.biopha.2018.06.136	NOUN
admet-2268	454	8	https://doi.org/10.1016/j.medidd.2024.100183	https://doi.org/10.1016/j.medidd.2024.100183	VERB
admet-2268	454	9	https://doi.org/10.1016/j.jddst.2023.105106	https://doi.org/10.1016/j.jddst.2023.105106	ADJ
admet-2268	454	10	https://doi.org/10.3390/pharmaceutics12090855	https://doi.org/10.3390/pharmaceutics12090855	PROPN
admet-2268	454	11	https://doi.org/10.1016/j.ijpharm.2019.118817	https://doi.org/10.1016/j.ijpharm.2019.118817	PROPN
admet-2268	454	12	https://doi.org/10.4172/0975-0851.1000385	https://doi.org/10.4172/0975-0851.1000385	PROPN
admet-2268	455	1	https://doi.org/10.1016/j.jddst.2021.102758	https://doi.org/10.1016/j.jddst.2021.102758	PROPN
admet-2268	455	2	admet	admet	PROPN
admet-2268	455	3	&	&	CCONJ
admet-2268	455	4	dmpk	dmpk	PROPN
admet-2268	455	5	12(3	12(3	PROPN
admet-2268	455	6	)	)	PUNCT
admet-2268	455	7	(	(	PUNCT
admet-2268	455	8	2024	2024	NUM
admet-2268	455	9	)	)	PUNCT
admet-2268	455	10	553	553	NUM
admet-2268	455	11	-	-	SYM
admet-2268	455	12	580	580	NUM
admet-2268	455	13	berberine	berberine	NOUN
admet-2268	455	14	hcl	hcl	PROPN
admet-2268	455	15	and	and	CCONJ
admet-2268	455	16	diacerein	diacerein	ADV
admet-2268	455	17	loaded	load	VERB
admet-2268	455	18	dual	dual	ADJ
admet-2268	455	19	delivery	delivery	NOUN
admet-2268	455	20	transferosomes	transferosome	NOUN
admet-2268	455	21	doi	doi	PROPN
admet-2268	455	22	:	:	PUNCT
admet-2268	455	23	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	455	24	577	577	NUM
admet-2268	455	25	[	[	X
admet-2268	455	26	14	14	NUM
admet-2268	455	27	]	]	PUNCT
admet-2268	455	28	a.	a.	NOUN
admet-2268	455	29	kumar	kumar	PROPN
admet-2268	455	30	,	,	PUNCT
admet-2268	455	31	k.	k.	PROPN
admet-2268	455	32	chopra	chopra	PROPN
admet-2268	455	33	,	,	PUNCT
admet-2268	455	34	m.	m.	NOUN
admet-2268	455	35	mukherjee	mukherjee	PROPN
admet-2268	455	36	,	,	PUNCT
admet-2268	455	37	r.	r.	PROPN
admet-2268	455	38	pottabathini	pottabathini	PROPN
admet-2268	455	39	,	,	PUNCT
admet-2268	455	40	d.k	d.k	PROPN
admet-2268	455	41	.	.	PROPN
admet-2268	455	42	dhull	dhull	PROPN
admet-2268	455	43	.	.	PUNCT
admet-2268	456	1	current	current	ADJ
admet-2268	456	2	knowledge	knowledge	NOUN
admet-2268	456	3	and	and	CCONJ
admet-2268	456	4	pharmacological	pharmacological	ADJ
admet-2268	456	5	profile	profile	NOUN
admet-2268	456	6	of	of	ADP
admet-2268	456	7	berberine	berberine	NOUN
admet-2268	456	8	:	:	PUNCT
admet-2268	456	9	an	an	DET
admet-2268	456	10	update	update	NOUN
admet-2268	456	11	.	.	PUNCT
admet-2268	457	1	european	european	ADJ
admet-2268	457	2	journal	journal	PROPN
admet-2268	457	3	of	of	ADP
admet-2268	457	4	pharmacology	pharmacology	NOUN
admet-2268	457	5	761	761	NUM
admet-2268	457	6	(	(	PUNCT
admet-2268	457	7	2015	2015	NUM
admet-2268	457	8	)	)	PUNCT
admet-2268	457	9	288297	288297	NUM
admet-2268	457	10	.	.	PUNCT
admet-2268	458	1	https://doi.org/10.1016/j.ejphar.2015.05.068	https://doi.org/10.1016/j.ejphar.2015.05.068	PROPN
admet-2268	458	2	.	.	PUNCT
admet-2268	459	1	[	[	X
admet-2268	459	2	15	15	NUM
admet-2268	459	3	]	]	X
admet-2268	459	4	s.	s.	PROPN
admet-2268	459	5	sun	sun	PROPN
admet-2268	459	6	,	,	PUNCT
admet-2268	459	7	x.	x.	PROPN
admet-2268	459	8	zhang	zhang	PROPN
admet-2268	459	9	,	,	PUNCT
admet-2268	459	10	m.	m.	PROPN
admet-2268	459	11	xu	xu	PROPN
admet-2268	459	12	,	,	PUNCT
admet-2268	459	13	f.	f.	PROPN
admet-2268	459	14	zhang	zhang	PROPN
admet-2268	459	15	,	,	PUNCT
admet-2268	459	16	f.	f.	PROPN
admet-2268	459	17	tian	tian	PROPN
admet-2268	459	18	,	,	PUNCT
admet-2268	459	19	j.	j.	PROPN
admet-2268	459	20	cui	cui	PROPN
admet-2268	459	21	,	,	PUNCT
admet-2268	459	22	y.	y.	PROPN
admet-2268	459	23	xia	xia	PROPN
admet-2268	459	24	,	,	PUNCT
admet-2268	459	25	c.	c.	PROPN
admet-2268	459	26	liang	liang	PROPN
admet-2268	459	27	,	,	PUNCT
admet-2268	459	28	s.	s.	PROPN
admet-2268	459	29	zhou	zhou	PROPN
admet-2268	459	30	,	,	PUNCT
admet-2268	459	31	h.	h.	PROPN
admet-2268	459	32	wei	wei	PROPN
admet-2268	459	33	,	,	PUNCT
admet-2268	459	34	h.	h.	PROPN
admet-2268	459	35	zhao	zhao	PROPN
admet-2268	459	36	,	,	PUNCT
admet-2268	459	37	g.	g.	PROPN
admet-2268	459	38	wu	wu	PROPN
admet-2268	459	39	,	,	PUNCT
admet-2268	459	40	b.	b.	PROPN
admet-2268	459	41	xu	xu	PROPN
admet-2268	459	42	,	,	PUNCT
admet-2268	459	43	x.	x.	PROPN
admet-2268	459	44	liu	liu	PROPN
admet-2268	459	45	,	,	PUNCT
admet-2268	459	46	g.	g.	PROPN
admet-2268	459	47	yang	yang	PROPN
admet-2268	459	48	,	,	PUNCT
admet-2268	459	49	q.	q.	PROPN
admet-2268	459	50	wang	wang	PROPN
admet-2268	459	51	,	,	PUNCT
admet-2268	459	52	l.	l.	PROPN
admet-2268	459	53	zhang	zhang	PROPN
admet-2268	459	54	,	,	PUNCT
admet-2268	459	55	y.	y.	PROPN
admet-2268	459	56	gong	gong	PROPN
admet-2268	459	57	,	,	PUNCT
admet-2268	459	58	c.	c.	PROPN
admet-2268	459	59	shao	shao	PROPN
admet-2268	459	60	,	,	PUNCT
admet-2268	459	61	y.	y.	PROPN
admet-2268	459	62	zou	zou	PROPN
admet-2268	459	63	.	.	PUNCT
admet-2268	459	64	berberine	berberine	PROPN
admet-2268	459	65	downregulates	downregulate	NOUN
admet-2268	459	66	cdc6	cdc6	VERB
admet-2268	459	67	and	and	CCONJ
admet-2268	459	68	inhibits	inhibit	VERB
admet-2268	459	69	proliferation	proliferation	NOUN
admet-2268	459	70	via	via	ADP
admet-2268	459	71	targeting	target	VERB
admet-2268	459	72	jak	jak	PROPN
admet-2268	459	73	-	-	PUNCT
admet-2268	459	74	stat3	stat3	NOUN
admet-2268	459	75	signaling	signal	VERB
admet-2268	459	76	in	in	ADP
admet-2268	459	77	keratinocytes	keratinocyte	NOUN
admet-2268	459	78	.	.	PUNCT
admet-2268	460	1	cell	cell	NOUN
admet-2268	460	2	death	death	NOUN
admet-2268	460	3	&	&	CCONJ
admet-2268	460	4	disease	disease	PROPN
admet-2268	460	5	10	10	NUM
admet-2268	460	6	(	(	PUNCT
admet-2268	460	7	2019	2019	NUM
admet-2268	460	8	)	)	PUNCT
admet-2268	460	9	274	274	NUM
admet-2268	460	10	.	.	PUNCT
admet-2268	461	1	https://doi.org/10.1038/s41419-019-1510-8	https://doi.org/10.1038/s41419-019-1510-8	NUM
admet-2268	461	2	.	.	PUNCT
admet-2268	462	1	[	[	X
admet-2268	462	2	16	16	NUM
admet-2268	462	3	]	]	X
admet-2268	462	4	s.m	s.m	PROPN
admet-2268	462	5	.	.	PROPN
admet-2268	462	6	brunner	brunner	PROPN
admet-2268	462	7	,	,	PUNCT
admet-2268	462	8	a.	a.	NOUN
admet-2268	462	9	ramspacher	ramspacher	PROPN
admet-2268	462	10	,	,	PUNCT
admet-2268	462	11	c.	c.	PROPN
admet-2268	462	12	rieser	rieser	PROPN
admet-2268	462	13	,	,	PUNCT
admet-2268	462	14	j.	j.	PROPN
admet-2268	462	15	leitner	leitner	PROPN
admet-2268	462	16	,	,	PUNCT
admet-2268	462	17	h.	h.	PROPN
admet-2268	462	18	heil	heil	PROPN
admet-2268	462	19	,	,	PUNCT
admet-2268	462	20	m.	m.	NOUN
admet-2268	462	21	ablinger	ablinger	PROPN
admet-2268	462	22	,	,	PUNCT
admet-2268	462	23	j.	j.	PROPN
admet-2268	462	24	tevini	tevini	PROPN
admet-2268	462	25	,	,	PUNCT
admet-2268	462	26	m.	m.	PROPN
admet-2268	462	27	wimmer	wimmer	PROPN
admet-2268	462	28	,	,	PUNCT
admet-2268	462	29	a.	a.	PROPN
admet-2268	462	30	koller	koller	PROPN
admet-2268	462	31	,	,	PUNCT
admet-2268	462	32	j.	j.	PROPN
admet-2268	462	33	piñón	piñón	PROPN
admet-2268	462	34	hofbauer	hofbauer	PROPN
admet-2268	462	35	,	,	PUNCT
admet-2268	462	36	t.k	t.k	PROPN
admet-2268	462	37	.	.	PROPN
admet-2268	462	38	felder	felder	PROPN
admet-2268	462	39	,	,	PUNCT
admet-2268	462	40	j.w	j.w	PROPN
admet-2268	462	41	.	.	PROPN
admet-2268	462	42	bauer	bauer	PROPN
admet-2268	462	43	,	,	PUNCT
admet-2268	462	44	b.	b.	PROPN
admet-2268	462	45	kofler	kofler	PROPN
admet-2268	462	46	,	,	PUNCT
admet-2268	462	47	r.	r.	PROPN
admet-2268	462	48	lang	lang	PROPN
admet-2268	462	49	,	,	PUNCT
admet-2268	462	50	v.	v.	PROPN
admet-2268	462	51	wally	wally	PROPN
admet-2268	462	52	.	.	PUNCT
admet-2268	463	1	topical	topical	ADJ
admet-2268	463	2	diacerein	diacerein	ADJ
admet-2268	463	3	decreases	decrease	VERB
admet-2268	463	4	skin	skin	NOUN
admet-2268	463	5	and	and	CCONJ
admet-2268	463	6	splenic	splenic	ADJ
admet-2268	463	7	cd11c+	cd11c+	NOUN
admet-2268	463	8	dendritic	dendritic	ADJ
admet-2268	463	9	cells	cell	NOUN
admet-2268	463	10	in	in	ADP
admet-2268	463	11	psoriasis	psoriasis	NOUN
admet-2268	463	12	.	.	PUNCT
admet-2268	464	1	international	international	ADJ
admet-2268	464	2	journal	journal	NOUN
admet-2268	464	3	of	of	ADP
admet-2268	464	4	molecular	molecular	ADJ
admet-2268	464	5	sciences	science	NOUN
admet-2268	464	6	24	24	NUM
admet-2268	464	7	(	(	PUNCT
admet-2268	464	8	2023	2023	NUM
admet-2268	464	9	)	)	PUNCT
admet-2268	464	10	4324	4324	NUM
admet-2268	464	11	.	.	PUNCT
admet-2268	465	1	https://doi.org/10.3390/ijms24054324	https://doi.org/10.3390/ijms24054324	NOUN
admet-2268	465	2	.	.	PUNCT
admet-2268	466	1	[	[	X
admet-2268	466	2	17	17	NUM
admet-2268	466	3	]	]	PUNCT
admet-2268	466	4	k.	k.	PROPN
admet-2268	466	5	baxi	baxi	PROPN
admet-2268	466	6	,	,	PUNCT
admet-2268	466	7	d.	d.	PROPN
admet-2268	466	8	majmundar	majmundar	PROPN
admet-2268	466	9	,	,	PUNCT
admet-2268	466	10	a.	a.	NOUN
admet-2268	466	11	patel	patel	PROPN
admet-2268	466	12	,	,	PUNCT
admet-2268	466	13	v.	v.	PROPN
admet-2268	466	14	chandibhamar	chandibhamar	PROPN
admet-2268	466	15	,	,	PUNCT
admet-2268	466	16	n.	n.	PROPN
admet-2268	466	17	patel	patel	PROPN
admet-2268	466	18	,	,	PUNCT
admet-2268	466	19	v.	v.	PROPN
admet-2268	466	20	majmundar	majmundar	PROPN
admet-2268	466	21	.	.	PUNCT
admet-2268	467	1	diacerein	diacerein	ADJ
admet-2268	467	2	in	in	ADP
admet-2268	467	3	the	the	DET
admet-2268	467	4	treatment	treatment	NOUN
admet-2268	467	5	of	of	ADP
admet-2268	467	6	chronic	chronic	ADJ
admet-2268	467	7	plaque	plaque	NOUN
admet-2268	467	8	psoriasis	psoriasis	NOUN
admet-2268	467	9	:	:	PUNCT
admet-2268	467	10	a	a	DET
admet-2268	467	11	case	case	NOUN
admet-2268	467	12	report	report	NOUN
admet-2268	467	13	.	.	PUNCT
admet-2268	468	1	indian	indian	ADJ
admet-2268	468	2	journal	journal	PROPN
admet-2268	468	3	of	of	ADP
admet-2268	468	4	drugs	drug	NOUN
admet-2268	468	5	in	in	ADP
admet-2268	468	6	dermatology	dermatology	NOUN
admet-2268	468	7	8	8	NUM
admet-2268	468	8	(	(	PUNCT
admet-2268	468	9	2022	2022	NUM
admet-2268	468	10	)	)	PUNCT
admet-2268	468	11	79	79	NUM
admet-2268	468	12	.	.	PUNCT
admet-2268	469	1	https://doi.org/10.4103/ijdd.ijdd_19_21	https://doi.org/10.4103/ijdd.ijdd_19_21	PROPN
admet-2268	469	2	.	.	PUNCT
admet-2268	470	1	[	[	X
admet-2268	470	2	18	18	NUM
admet-2268	470	3	]	]	X
admet-2268	470	4	g.f	g.f	PROPN
admet-2268	470	5	.	.	PROPN
admet-2268	470	6	balata	balata	PROPN
admet-2268	470	7	,	,	PUNCT
admet-2268	470	8	m.m	m.m	PROPN
admet-2268	470	9	.	.	PROPN
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admet-2268	470	11	,	,	PUNCT
admet-2268	470	12	h.a	h.a	PROPN
admet-2268	470	13	.	.	PROPN
admet-2268	470	14	elghamry	elghamry	PROPN
admet-2268	470	15	,	,	PUNCT
admet-2268	470	16	s.a	s.a	PROPN
admet-2268	470	17	.	.	PROPN
admet-2268	470	18	sabry	sabry	PROPN
admet-2268	470	19	.	.	PUNCT
admet-2268	471	1	preparation	preparation	NOUN
admet-2268	471	2	and	and	CCONJ
admet-2268	471	3	characterization	characterization	NOUN
admet-2268	471	4	of	of	ADP
admet-2268	471	5	ivabradine	ivabradine	NOUN
admet-2268	471	6	hcl	hcl	PROPN
admet-2268	471	7	transfersomes	transfersome	NOUN
admet-2268	471	8	for	for	ADP
admet-2268	471	9	enhanced	enhanced	ADJ
admet-2268	471	10	transdermal	transdermal	ADJ
admet-2268	471	11	delivery	delivery	NOUN
admet-2268	471	12	.	.	PUNCT
admet-2268	472	1	journal	journal	NOUN
admet-2268	472	2	of	of	ADP
admet-2268	472	3	drug	drug	NOUN
admet-2268	472	4	delivery	delivery	NOUN
admet-2268	472	5	science	science	NOUN
admet-2268	472	6	and	and	CCONJ
admet-2268	472	7	technology	technology	NOUN
admet-2268	472	8	60	60	NUM
admet-2268	472	9	(	(	PUNCT
admet-2268	472	10	2020	2020	NUM
admet-2268	472	11	)	)	PUNCT
admet-2268	472	12	101921	101921	NUM
admet-2268	472	13	.	.	PUNCT
admet-2268	473	1	https://doi.org/10.1016/j.jddst.2020.101921	https://doi.org/10.1016/j.jddst.2020.101921	PROPN
admet-2268	473	2	.	.	PUNCT
admet-2268	474	1	[	[	X
admet-2268	474	2	19	19	NUM
admet-2268	474	3	]	]	X
admet-2268	474	4	a.k	a.k	PROPN
admet-2268	474	5	.	.	PROPN
admet-2268	474	6	singh	singh	PROPN
admet-2268	474	7	,	,	PUNCT
admet-2268	474	8	s.s	s.s	PROPN
admet-2268	474	9	.	.	PROPN
admet-2268	474	10	singh	singh	PROPN
admet-2268	474	11	,	,	PUNCT
admet-2268	474	12	a.s	a.s	PROPN
admet-2268	474	13	.	.	PROPN
admet-2268	474	14	rathore	rathore	PROPN
admet-2268	474	15	,	,	PUNCT
admet-2268	474	16	s.p	s.p	PROPN
admet-2268	474	17	.	.	PROPN
admet-2268	474	18	singh	singh	PROPN
admet-2268	474	19	,	,	PUNCT
admet-2268	474	20	g.	g.	PROPN
admet-2268	474	21	mishra	mishra	PROPN
admet-2268	474	22	,	,	PUNCT
admet-2268	474	23	r.	r.	PROPN
admet-2268	474	24	awasthi	awasthi	PROPN
admet-2268	474	25	,	,	PUNCT
admet-2268	474	26	s.k	s.k	PROPN
admet-2268	474	27	.	.	PROPN
admet-2268	474	28	mishra	mishra	PROPN
admet-2268	474	29	,	,	PUNCT
admet-2268	474	30	v.	v.	PROPN
admet-2268	474	31	gautam	gautam	PROPN
admet-2268	474	32	,	,	PUNCT
admet-2268	474	33	s.k	s.k	PROPN
admet-2268	474	34	.	.	PROPN
admet-2268	474	35	singh	singh	PROPN
admet-2268	474	36	.	.	PUNCT
admet-2268	475	1	lipid	lipid	NOUN
admet-2268	475	2	-	-	PUNCT
admet-2268	475	3	coated	coat	VERB
admet-2268	475	4	mcm-41	mcm-41	DET
admet-2268	475	5	mesoporous	mesoporous	ADJ
admet-2268	475	6	silica	silica	NOUN
admet-2268	475	7	nanoparticles	nanoparticle	NOUN
admet-2268	475	8	loaded	load	VERB
admet-2268	475	9	with	with	ADP
admet-2268	475	10	berberine	berberine	NOUN
admet-2268	475	11	improved	improve	VERB
admet-2268	475	12	inhibition	inhibition	NOUN
admet-2268	475	13	of	of	ADP
admet-2268	475	14	acetylcholine	acetylcholine	ADJ
admet-2268	475	15	esterase	esterase	NOUN
admet-2268	475	16	and	and	CCONJ
admet-2268	475	17	amyloid	amyloid	NOUN
admet-2268	475	18	formation	formation	NOUN
admet-2268	475	19	.	.	PUNCT
admet-2268	476	1	acs	acs	PROPN
admet-2268	476	2	biomaterials	biomaterials	PROPN
admet-2268	476	3	science	science	PROPN
admet-2268	476	4	&	&	CCONJ
admet-2268	476	5	engineering	engineering	PROPN
admet-2268	476	6	7	7	NUM
admet-2268	476	7	(	(	PUNCT
admet-2268	476	8	2021	2021	NUM
admet-2268	476	9	)	)	PUNCT
admet-2268	476	10	3737	3737	NUM
admet-2268	476	11	-	-	SYM
admet-2268	476	12	3753	3753	NUM
admet-2268	476	13	.	.	PUNCT
admet-2268	477	1	https://doi.org/10.1021/acsbiomaterials.1c00514	https://doi.org/10.1021/acsbiomaterials.1c00514	NOUN
admet-2268	477	2	.	.	PUNCT
admet-2268	478	1	[	[	X
admet-2268	478	2	20	20	NUM
admet-2268	478	3	]	]	X
admet-2268	478	4	g.	g.	PROPN
admet-2268	478	5	mishra	mishra	PROPN
admet-2268	478	6	,	,	PUNCT
admet-2268	478	7	r.	r.	PROPN
admet-2268	478	8	awasthi	awasthi	PROPN
admet-2268	478	9	,	,	PUNCT
admet-2268	478	10	a.k	a.k	PROPN
admet-2268	478	11	.	.	PROPN
admet-2268	478	12	singh	singh	PROPN
admet-2268	478	13	,	,	PUNCT
admet-2268	478	14	s.	s.	PROPN
admet-2268	478	15	singh	singh	PROPN
admet-2268	478	16	,	,	PUNCT
admet-2268	478	17	s.k	s.k	PROPN
admet-2268	478	18	.	.	PROPN
admet-2268	478	19	mishra	mishra	PROPN
admet-2268	478	20	,	,	PUNCT
admet-2268	478	21	s.k	s.k	PROPN
admet-2268	478	22	.	.	PROPN
admet-2268	478	23	singh	singh	PROPN
admet-2268	478	24	,	,	PUNCT
admet-2268	478	25	m.k	m.k	PROPN
admet-2268	478	26	.	.	PUNCT
admet-2268	479	1	nandi	nandi	PROPN
admet-2268	479	2	.	.	PUNCT
admet-2268	480	1	intranasally	intranasally	ADV
admet-2268	480	2	coadministered	coadministere	VERB
admet-2268	480	3	berberine	berberine	NOUN
admet-2268	480	4	and	and	CCONJ
admet-2268	480	5	curcumin	curcumin	NOUN
admet-2268	480	6	loaded	load	VERB
admet-2268	480	7	in	in	ADP
admet-2268	480	8	transfersomal	transfersomal	ADJ
admet-2268	480	9	vesicles	vesicle	NOUN
admet-2268	480	10	improved	improve	VERB
admet-2268	480	11	inhibition	inhibition	NOUN
admet-2268	480	12	of	of	ADP
admet-2268	480	13	amyloid	amyloid	NOUN
admet-2268	480	14	formation	formation	NOUN
admet-2268	480	15	and	and	CCONJ
admet-2268	480	16	bace-1	bace-1	PROPN
admet-2268	480	17	.	.	PUNCT
admet-2268	481	1	acs	acs	PROPN
admet-2268	481	2	omega	omega	NOUN
admet-2268	481	3	7	7	NUM
admet-2268	481	4	(	(	PUNCT
admet-2268	481	5	2022	2022	NUM
admet-2268	481	6	)	)	PUNCT
admet-2268	481	7	43290	43290	NUM
admet-2268	481	8	-	-	SYM
admet-2268	481	9	43305	43305	NUM
admet-2268	481	10	.	.	PUNCT
admet-2268	482	1	https://doi.org/10.1021/acsomega.2c06215	https://doi.org/10.1021/acsomega.2c06215	NOUN
admet-2268	482	2	.	.	PUNCT
admet-2268	483	1	[	[	X
admet-2268	483	2	21	21	NUM
admet-2268	483	3	]	]	X
admet-2268	483	4	d.	d.	PROPN
admet-2268	483	5	arora	arora	PROPN
admet-2268	483	6	,	,	PUNCT
admet-2268	483	7	s.	s.	PROPN
admet-2268	483	8	nanda	nanda	PROPN
admet-2268	483	9	.	.	PUNCT
admet-2268	484	1	quality	quality	NOUN
admet-2268	484	2	by	by	ADP
admet-2268	484	3	design	design	NOUN
admet-2268	484	4	driven	drive	VERB
admet-2268	484	5	development	development	NOUN
admet-2268	484	6	of	of	ADP
admet-2268	484	7	resveratrol	resveratrol	NOUN
admet-2268	484	8	loaded	load	VERB
admet-2268	484	9	ethosomal	ethosomal	ADJ
admet-2268	484	10	hydrogel	hydrogel	NOUN
admet-2268	484	11	for	for	ADP
admet-2268	484	12	improved	improve	VERB
admet-2268	484	13	dermatological	dermatological	ADJ
admet-2268	484	14	benefits	benefit	NOUN
admet-2268	484	15	via	via	ADP
admet-2268	484	16	enhanced	enhance	VERB
admet-2268	484	17	skin	skin	NOUN
admet-2268	484	18	permeation	permeation	NOUN
admet-2268	484	19	and	and	CCONJ
admet-2268	484	20	retention	retention	NOUN
admet-2268	484	21	.	.	PUNCT
admet-2268	485	1	international	international	ADJ
admet-2268	485	2	journal	journal	PROPN
admet-2268	485	3	of	of	ADP
admet-2268	485	4	pharmaceutics	pharmaceutic	NOUN
admet-2268	485	5	.	.	PUNCT
admet-2268	486	1	567	567	NUM
admet-2268	486	2	(	(	PUNCT
admet-2268	486	3	2019	2019	NUM
admet-2268	486	4	)	)	PUNCT
admet-2268	486	5	118448	118448	NUM
admet-2268	486	6	.	.	PUNCT
admet-2268	487	1	https://doi.org/10.1016/j.ijpharm.2019.118448	https://doi.org/10.1016/j.ijpharm.2019.118448	X
admet-2268	487	2	.	.	PUNCT
admet-2268	488	1	[	[	X
admet-2268	488	2	22	22	NUM
admet-2268	488	3	]	]	PUNCT
admet-2268	488	4	m.	m.	NOUN
admet-2268	488	5	dahiya	dahiya	PROPN
admet-2268	488	6	,	,	PUNCT
admet-2268	488	7	r.	r.	PROPN
admet-2268	488	8	awasthi	awasthi	PROPN
admet-2268	488	9	,	,	PUNCT
admet-2268	488	10	j.p	j.p	PROPN
admet-2268	488	11	.	.	PROPN
admet-2268	488	12	yadav	yadav	PROPN
admet-2268	488	13	,	,	PUNCT
admet-2268	488	14	s.	s.	PROPN
admet-2268	488	15	sharma	sharma	PROPN
admet-2268	488	16	,	,	PUNCT
admet-2268	488	17	k.	k.	PROPN
admet-2268	488	18	dua	dua	PROPN
admet-2268	488	19	,	,	PUNCT
admet-2268	488	20	h.	h.	PROPN
admet-2268	488	21	dureja	dureja	PROPN
admet-2268	488	22	.	.	PUNCT
admet-2268	489	1	chitosan	chitosan	PROPN
admet-2268	489	2	based	base	VERB
admet-2268	489	3	sorafenib	sorafenib	NOUN
admet-2268	489	4	tosylate	tosylate	VERB
admet-2268	489	5	loaded	loaded	ADJ
admet-2268	489	6	magnetic	magnetic	ADJ
admet-2268	489	7	nanoparticles	nanoparticle	NOUN
admet-2268	489	8	:	:	PUNCT
admet-2268	489	9	formulation	formulation	NOUN
admet-2268	489	10	and	and	CCONJ
admet-2268	489	11	in	in	ADP
admet-2268	489	12	-	-	PUNCT
admet-2268	489	13	vitro	vitro	X
admet-2268	489	14	characterization	characterization	NOUN
admet-2268	489	15	.	.	PUNCT
admet-2268	490	1	international	international	ADJ
admet-2268	490	2	journal	journal	NOUN
admet-2268	490	3	of	of	ADP
admet-2268	490	4	biological	biological	ADJ
admet-2268	490	5	macromolecules	macromolecule	NOUN
admet-2268	490	6	242	242	NUM
admet-2268	490	7	(	(	PUNCT
admet-2268	490	8	2023	2023	NUM
admet-2268	490	9	)	)	PUNCT
admet-2268	490	10	124919	124919	NUM
admet-2268	490	11	.	.	PUNCT
admet-2268	491	1	https://doi.org/10.1016/j.ijbiomac.2023.124919	https://doi.org/10.1016/j.ijbiomac.2023.124919	PROPN
admet-2268	491	2	.	.	PUNCT
admet-2268	492	1	[	[	X
admet-2268	492	2	23	23	NUM
admet-2268	492	3	]	]	X
admet-2268	492	4	u.	u.	NOUN
admet-2268	492	5	varia	varia	PROPN
admet-2268	492	6	,	,	PUNCT
admet-2268	492	7	d.	d.	PROPN
admet-2268	492	8	joshi	joshi	PROPN
admet-2268	492	9	,	,	PUNCT
admet-2268	492	10	m.	m.	NOUN
admet-2268	492	11	jadeja	jadeja	PROPN
admet-2268	492	12	,	,	PUNCT
admet-2268	492	13	h.	h.	PROPN
admet-2268	492	14	katariya	katariya	PROPN
admet-2268	492	15	,	,	PUNCT
admet-2268	492	16	k.	k.	PROPN
admet-2268	492	17	detholia	detholia	PROPN
admet-2268	492	18	,	,	PUNCT
admet-2268	492	19	v.	v.	ADP
admet-2268	492	20	soni	soni	PROPN
admet-2268	492	21	.	.	PUNCT
admet-2268	493	1	development	development	NOUN
admet-2268	493	2	and	and	CCONJ
admet-2268	493	3	evaluation	evaluation	NOUN
admet-2268	493	4	of	of	ADP
admet-2268	493	5	ultradeformable	ultradeformable	ADJ
admet-2268	493	6	vesicles	vesicle	NOUN
admet-2268	493	7	loaded	load	VERB
admet-2268	493	8	transdermal	transdermal	ADJ
admet-2268	493	9	film	film	NOUN
admet-2268	493	10	of	of	ADP
admet-2268	493	11	boswellic	boswellic	ADJ
admet-2268	493	12	acid	acid	NOUN
admet-2268	493	13	.	.	PUNCT
admet-2268	494	1	future	future	ADJ
admet-2268	494	2	journal	journal	PROPN
admet-2268	494	3	of	of	ADP
admet-2268	494	4	pharmaceutical	pharmaceutical	ADJ
admet-2268	494	5	sciences	science	NOUN
admet-2268	494	6	8	8	NUM
admet-2268	494	7	(	(	PUNCT
admet-2268	494	8	2022	2022	NUM
admet-2268	494	9	)	)	PUNCT
admet-2268	494	10	1	1	NUM
admet-2268	494	11	-	-	SYM
admet-2268	494	12	16	16	NUM
admet-2268	494	13	.	.	PUNCT
admet-2268	494	14	https://doi.org/10.1186/s43094-022-00428-2	https://doi.org/10.1186/s43094-022-00428-2	NOUN
admet-2268	494	15	.	.	PUNCT
admet-2268	495	1	[	[	X
admet-2268	495	2	24	24	NUM
admet-2268	495	3	]	]	X
admet-2268	495	4	h.	h.	PROPN
admet-2268	495	5	abd	abd	PROPN
admet-2268	495	6	-	-	PUNCT
admet-2268	495	7	allah	allah	PROPN
admet-2268	495	8	,	,	PUNCT
admet-2268	495	9	m.h	m.h	PROPN
admet-2268	495	10	.	.	PROPN
admet-2268	495	11	ragaie	ragaie	PROPN
admet-2268	495	12	,	,	PUNCT
admet-2268	495	13	e.	e.	PROPN
admet-2268	495	14	elmowafy	elmowafy	PROPN
admet-2268	495	15	.	.	PUNCT
admet-2268	496	1	unraveling	unravel	VERB
admet-2268	496	2	the	the	DET
admet-2268	496	3	pharmaceutical	pharmaceutical	ADJ
admet-2268	496	4	and	and	CCONJ
admet-2268	496	5	clinical	clinical	ADJ
admet-2268	496	6	relevance	relevance	NOUN
admet-2268	496	7	of	of	ADP
admet-2268	496	8	the	the	DET
admet-2268	496	9	influence	influence	NOUN
admet-2268	496	10	of	of	ADP
admet-2268	496	11	syringic	syringic	ADJ
admet-2268	496	12	acid	acid	NOUN
admet-2268	496	13	loaded	load	VERB
admet-2268	496	14	linoleic	linoleic	NOUN
admet-2268	496	15	acid	acid	NOUN
admet-2268	496	16	transferosomes	transferosome	NOUN
admet-2268	496	17	on	on	ADP
admet-2268	496	18	acne	acne	NOUN
admet-2268	496	19	.	.	PUNCT
admet-2268	497	1	international	international	ADJ
admet-2268	497	2	journal	journal	PROPN
admet-2268	497	3	of	of	ADP
admet-2268	497	4	pharmaceutics	pharmaceutic	NOUN
admet-2268	497	5	639	639	NUM
admet-2268	497	6	(	(	PUNCT
admet-2268	497	7	2023	2023	NUM
admet-2268	497	8	)	)	PUNCT
admet-2268	497	9	122940	122940	NUM
admet-2268	497	10	.	.	PUNCT
admet-2268	498	1	https://doi.org/10.1016/j.ijpharm.2023.122940	https://doi.org/10.1016/j.ijpharm.2023.122940	NOUN
admet-2268	498	2	.	.	PUNCT
admet-2268	499	1	[	[	X
admet-2268	499	2	25	25	NUM
admet-2268	499	3	]	]	X
admet-2268	499	4	g.e	g.e	PROPN
admet-2268	499	5	.	.	PROPN
admet-2268	499	6	gómez	gómez	PROPN
admet-2268	499	7	,	,	PUNCT
admet-2268	499	8	m.n	m.n	PROPN
admet-2268	499	9	.	.	PROPN
admet-2268	499	10	calienni	calienni	PROPN
admet-2268	499	11	,	,	PUNCT
admet-2268	499	12	s.d.v	s.d.v	NOUN
admet-2268	499	13	.	.	PUNCT
admet-2268	499	14	alonso	alonso	PROPN
admet-2268	499	15	,	,	PUNCT
admet-2268	499	16	f.c	f.c	PROPN
admet-2268	499	17	.	.	PROPN
admet-2268	499	18	alvira	alvira	PROPN
admet-2268	499	19	,	,	PUNCT
admet-2268	499	20	j.	j.	PROPN
admet-2268	499	21	montanari	montanari	PROPN
admet-2268	499	22	.	.	PUNCT
admet-2268	499	23	raman	raman	NOUN
admet-2268	499	24	spectroscopy	spectroscopy	NOUN
admet-2268	499	25	to	to	PART
admet-2268	499	26	monitor	monitor	VERB
admet-2268	499	27	the	the	DET
admet-2268	499	28	delivery	delivery	NOUN
admet-2268	499	29	of	of	ADP
admet-2268	499	30	a	a	DET
admet-2268	499	31	nano	nano	NOUN
admet-2268	499	32	-	-	PUNCT
admet-2268	499	33	formulation	formulation	NOUN
admet-2268	499	34	of	of	ADP
admet-2268	499	35	vismodegib	vismodegib	NOUN
admet-2268	499	36	in	in	ADP
admet-2268	499	37	the	the	DET
admet-2268	499	38	skin	skin	NOUN
admet-2268	499	39	.	.	PUNCT
admet-2268	500	1	applied	apply	VERB
admet-2268	500	2	sciences	science	NOUN
admet-2268	500	3	13	13	NUM
admet-2268	500	4	(	(	PUNCT
admet-2268	500	5	2023	2023	NUM
admet-2268	500	6	)	)	PUNCT
admet-2268	500	7	7687	7687	NUM
admet-2268	500	8	.	.	PUNCT
admet-2268	501	1	https://doi.org/10.3390/app13137687	https://doi.org/10.3390/app13137687	NOUN
admet-2268	501	2	.	.	PUNCT
admet-2268	502	1	[	[	X
admet-2268	502	2	26	26	NUM
admet-2268	502	3	]	]	PUNCT
admet-2268	502	4	p.	p.	NOUN
admet-2268	502	5	bhardwaj	bhardwaj	PROPN
admet-2268	502	6	,	,	PUNCT
admet-2268	502	7	p.	p.	PROPN
admet-2268	502	8	tripathi	tripathi	PROPN
admet-2268	502	9	,	,	PUNCT
admet-2268	502	10	s.	s.	PROPN
admet-2268	502	11	pandey	pandey	PROPN
admet-2268	502	12	,	,	PUNCT
admet-2268	502	13	r.	r.	PROPN
admet-2268	502	14	gupta	gupta	PROPN
admet-2268	502	15	,	,	PUNCT
admet-2268	502	16	r.k	r.k	PROPN
admet-2268	502	17	.	.	PROPN
admet-2268	502	18	khar	khar	PROPN
admet-2268	502	19	,	,	PUNCT
admet-2268	502	20	p.r	p.r	PROPN
admet-2268	502	21	.	.	PROPN
admet-2268	502	22	patil	patil	PROPN
admet-2268	502	23	.	.	PUNCT
admet-2268	503	1	improved	improve	VERB
admet-2268	503	2	dermal	dermal	ADJ
admet-2268	503	3	delivery	delivery	NOUN
admet-2268	503	4	of	of	ADP
admet-2268	503	5	pentoxifylline	pentoxifylline	NOUN
admet-2268	503	6	niosomes	niosome	NOUN
admet-2268	503	7	for	for	ADP
admet-2268	503	8	the	the	DET
admet-2268	503	9	management	management	NOUN
admet-2268	503	10	of	of	ADP
admet-2268	503	11	psoriasis	psoriasis	NOUN
admet-2268	503	12	:	:	PUNCT
admet-2268	503	13	development	development	NOUN
admet-2268	503	14	,	,	PUNCT
admet-2268	503	15	optimization	optimization	NOUN
admet-2268	503	16	and	and	CCONJ
admet-2268	503	17	in	in	ADP
admet-2268	503	18	-	-	PUNCT
admet-2268	503	19	vivo	vivo	NOUN
admet-2268	503	20	studies	study	NOUN
admet-2268	503	21	in	in	ADP
admet-2268	503	22	imiquimod	imiquimod	ADJ
admet-2268	503	23	induced	induced	ADJ
admet-2268	503	24	psoriatic	psoriatic	ADJ
admet-2268	503	25	plaque	plaque	NOUN
admet-2268	503	26	model	model	NOUN
admet-2268	503	27	.	.	PUNCT
admet-2268	504	1	journal	journal	PROPN
admet-2268	504	2	of	of	ADP
admet-2268	504	3	drug	drug	NOUN
admet-2268	504	4	delivery	delivery	NOUN
admet-2268	504	5	science	science	NOUN
admet-2268	504	6	and	and	CCONJ
admet-2268	504	7	technology	technology	NOUN
admet-2268	504	8	75	75	NUM
admet-2268	504	9	(	(	PUNCT
admet-2268	504	10	2022	2022	NUM
admet-2268	504	11	)	)	PUNCT
admet-2268	504	12	103643	103643	NUM
admet-2268	504	13	.	.	PUNCT
admet-2268	505	1	https://doi.org/10.1016/j.jddst.2022.103643	https://doi.org/10.1016/j.jddst.2022.103643	NOUN
admet-2268	505	2	.	.	PUNCT
admet-2268	506	1	[	[	X
admet-2268	506	2	27	27	NUM
admet-2268	506	3	]	]	PUNCT
admet-2268	506	4	k.	k.	PROPN
admet-2268	506	5	yadav	yadav	PROPN
admet-2268	506	6	,	,	PUNCT
admet-2268	506	7	d.	d.	PROPN
admet-2268	506	8	singh	singh	PROPN
admet-2268	506	9	,	,	PUNCT
admet-2268	506	10	m.r	m.r	PROPN
admet-2268	506	11	.	.	PROPN
admet-2268	506	12	singh	singh	PROPN
admet-2268	506	13	.	.	PUNCT
admet-2268	507	1	nanovesicles	nanovesicle	NOUN
admet-2268	507	2	delivery	delivery	NOUN
admet-2268	507	3	approach	approach	NOUN
admet-2268	507	4	for	for	ADP
admet-2268	507	5	targeting	target	VERB
admet-2268	507	6	steroid	steroid	NOUN
admet-2268	507	7	mediated	mediate	VERB
admet-2268	507	8	mechanism	mechanism	NOUN
admet-2268	507	9	of	of	ADP
admet-2268	507	10	antipsoriatic	antipsoriatic	ADJ
admet-2268	507	11	therapeutics	therapeutic	NOUN
admet-2268	507	12	.	.	PUNCT
admet-2268	508	1	journal	journal	PROPN
admet-2268	508	2	of	of	ADP
admet-2268	508	3	drug	drug	NOUN
admet-2268	508	4	delivery	delivery	NOUN
admet-2268	508	5	science	science	NOUN
admet-2268	508	6	and	and	CCONJ
admet-2268	508	7	technology	technology	NOUN
admet-2268	508	8	65	65	NUM
admet-2268	508	9	(	(	PUNCT
admet-2268	508	10	2021	2021	NUM
admet-2268	508	11	)	)	PUNCT
admet-2268	508	12	102688	102688	NUM
admet-2268	508	13	.	.	PUNCT
admet-2268	509	1	https://doi.org/10.1016/j.jddst.2021.102688	https://doi.org/10.1016/j.jddst.2021.102688	ADJ
admet-2268	509	2	.	.	PUNCT
admet-2268	510	1	[	[	X
admet-2268	510	2	28	28	NUM
admet-2268	510	3	]	]	X
admet-2268	510	4	m.	m.	NOUN
admet-2268	510	5	dahiya	dahiya	PROPN
admet-2268	510	6	,	,	PUNCT
admet-2268	510	7	r.	r.	PROPN
admet-2268	510	8	awasthi	awasthi	PROPN
admet-2268	510	9	,	,	PUNCT
admet-2268	510	10	k.	k.	PROPN
admet-2268	510	11	dua	dua	PROPN
admet-2268	510	12	,	,	PUNCT
admet-2268	510	13	h.	h.	PROPN
admet-2268	510	14	dureja	dureja	PROPN
admet-2268	510	15	.	.	PUNCT
admet-2268	511	1	sorafenib	sorafenib	PROPN
admet-2268	511	2	tosylate	tosylate	VERB
admet-2268	511	3	loaded	loaded	ADJ
admet-2268	511	4	superparamagnetic	superparamagnetic	ADJ
admet-2268	511	5	nanoparticles	nanoparticle	NOUN
admet-2268	511	6	:	:	PUNCT
admet-2268	511	7	development	development	NOUN
admet-2268	511	8	,	,	PUNCT
admet-2268	511	9	optimization	optimization	NOUN
admet-2268	511	10	and	and	CCONJ
admet-2268	511	11	cytotoxicity	cytotoxicity	NOUN
admet-2268	511	12	analysis	analysis	NOUN
admet-2268	511	13	on	on	ADP
admet-2268	511	14	hepg2	hepg2	NOUN
admet-2268	511	15	human	human	ADJ
admet-2268	511	16	hepatocellular	hepatocellular	ADJ
admet-2268	511	17	carcinoma	carcinoma	NOUN
admet-2268	511	18	cell	cell	NOUN
admet-2268	511	19	line	line	NOUN
admet-2268	511	20	.	.	PUNCT
admet-2268	512	1	journal	journal	NOUN
admet-2268	512	2	of	of	ADP
admet-2268	512	3	drug	drug	NOUN
admet-2268	512	4	delivery	delivery	NOUN
admet-2268	512	5	science	science	NOUN
admet-2268	512	6	and	and	CCONJ
admet-2268	512	7	technology	technology	NOUN
admet-2268	512	8	79	79	NUM
admet-2268	512	9	(	(	PUNCT
admet-2268	512	10	2023	2023	NUM
admet-2268	512	11	)	)	PUNCT
admet-2268	512	12	104044	104044	NUM
admet-2268	512	13	.	.	PUNCT
admet-2268	513	1	https://doi.org/10.1016/j.jddst.2022.104044	https://doi.org/10.1016/j.jddst.2022.104044	PROPN
admet-2268	513	2	.	.	PUNCT
admet-2268	514	1	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	514	2	https://doi.org/10.1016/j.ejphar.2015.05.068	https://doi.org/10.1016/j.ejphar.2015.05.068	VERB
admet-2268	514	3	https://doi.org/10.1038/s41419-019-1510-8	https://doi.org/10.1038/s41419-019-1510-8	NUM
admet-2268	514	4	https://doi.org/10.3390/ijms24054324	https://doi.org/10.3390/ijms24054324	PROPN
admet-2268	514	5	https://doi.org/10.4103/ijdd.ijdd_19_21	https://doi.org/10.4103/ijdd.ijdd_19_21	PROPN
admet-2268	514	6	https://doi.org/10.1016/j.jddst.2020.101921	https://doi.org/10.1016/j.jddst.2020.101921	PROPN
admet-2268	514	7	https://doi.org/10.1021/acsbiomaterials.1c00514	https://doi.org/10.1021/acsbiomaterials.1c00514	PROPN
admet-2268	514	8	https://doi.org/10.1021/acsomega.2c06215	https://doi.org/10.1021/acsomega.2c06215	ADJ
admet-2268	514	9	https://doi.org/10.1016/j.ijpharm.2019.118448	https://doi.org/10.1016/j.ijpharm.2019.118448	PROPN
admet-2268	514	10	https://doi.org/10.1016/j.ijbiomac.2023.124919	https://doi.org/10.1016/j.ijbiomac.2023.124919	PROPN
admet-2268	514	11	https://doi.org/10.1186/s43094-022-00428-2	https://doi.org/10.1186/s43094-022-00428-2	ADJ
admet-2268	514	12	https://doi.org/10.1016/j.ijpharm.2023.122940	https://doi.org/10.1016/j.ijpharm.2023.122940	PROPN
admet-2268	514	13	https://doi.org/10.3390/app13137687	https://doi.org/10.3390/app13137687	PROPN
admet-2268	514	14	https://doi.org/10.1016/j.jddst.2022.103643	https://doi.org/10.1016/j.jddst.2022.103643	PROPN
admet-2268	514	15	https://doi.org/10.1016/j.jddst.2021.102688	https://doi.org/10.1016/j.jddst.2021.102688	PROPN
admet-2268	514	16	https://doi.org/10.1016/j.jddst.2022.104044	https://doi.org/10.1016/j.jddst.2022.104044	PROPN
admet-2268	514	17	s.	s.	PROPN
admet-2268	514	18	singh	singh	PROPN
admet-2268	514	19	and	and	CCONJ
admet-2268	514	20	r.	r.	PROPN
admet-2268	514	21	awasthi	awasthi	PROPN
admet-2268	514	22	admet	admet	PROPN
admet-2268	514	23	&	&	CCONJ
admet-2268	514	24	dmpk	dmpk	PROPN
admet-2268	514	25	12(3	12(3	PROPN
admet-2268	514	26	)	)	PUNCT
admet-2268	514	27	(	(	PUNCT
admet-2268	514	28	2024	2024	NUM
admet-2268	514	29	)	)	PUNCT
admet-2268	514	30	553	553	NUM
admet-2268	514	31	-	-	SYM
admet-2268	514	32	580	580	NUM
admet-2268	514	33	578	578	NUM
admet-2268	514	34	[	[	X
admet-2268	514	35	29	29	NUM
admet-2268	514	36	]	]	X
admet-2268	514	37	m.	m.	NOUN
admet-2268	514	38	qushawy	qushawy	PROPN
admet-2268	514	39	,	,	PUNCT
admet-2268	514	40	a.	a.	PROPN
admet-2268	514	41	nasr	nasr	PROPN
admet-2268	514	42	,	,	PUNCT
admet-2268	514	43	m.	m.	PROPN
admet-2268	514	44	abd	abd	PROPN
admet-2268	514	45	-	-	PUNCT
admet-2268	514	46	alhaseeb	alhaseeb	PROPN
admet-2268	514	47	,	,	PUNCT
admet-2268	514	48	s.	s.	PROPN
admet-2268	514	49	swidan	swidan	PROPN
admet-2268	514	50	.	.	PUNCT
admet-2268	515	1	design	design	NOUN
admet-2268	515	2	,	,	PUNCT
admet-2268	515	3	optimization	optimization	NOUN
admet-2268	515	4	and	and	CCONJ
admet-2268	515	5	characterization	characterization	NOUN
admet-2268	515	6	of	of	ADP
admet-2268	515	7	a	a	DET
admet-2268	515	8	transfersomal	transfersomal	ADJ
admet-2268	515	9	gel	gel	NOUN
admet-2268	515	10	using	use	VERB
admet-2268	515	11	miconazole	miconazole	NOUN
admet-2268	515	12	nitrate	nitrate	NOUN
admet-2268	515	13	for	for	ADP
admet-2268	515	14	the	the	DET
admet-2268	515	15	treatment	treatment	NOUN
admet-2268	515	16	of	of	ADP
admet-2268	515	17	candida	candida	PROPN
admet-2268	515	18	skin	skin	NOUN
admet-2268	515	19	infections	infection	NOUN
admet-2268	515	20	.	.	PUNCT
admet-2268	516	1	pharmaceutics	pharmaceutic	NOUN
admet-2268	516	2	10	10	NUM
admet-2268	516	3	(	(	PUNCT
admet-2268	516	4	2018	2018	NUM
admet-2268	516	5	)	)	PUNCT
admet-2268	516	6	26	26	NUM
admet-2268	516	7	.	.	PUNCT
admet-2268	516	8	https://doi.org/10.3390/pharmaceutics10010026	https://doi.org/10.3390/pharmaceutics10010026	PROPN
admet-2268	516	9	.	.	PUNCT
admet-2268	517	1	[	[	X
admet-2268	517	2	30	30	NUM
admet-2268	517	3	]	]	X
admet-2268	517	4	s.	s.	PROPN
admet-2268	517	5	vasanth	vasanth	PROPN
admet-2268	517	6	,	,	PUNCT
admet-2268	517	7	a.	a.	PROPN
admet-2268	517	8	dubey	dubey	PROPN
admet-2268	517	9	,	,	PUNCT
admet-2268	517	10	r.	r.	PROPN
admet-2268	517	11	g	g	PROPN
admet-2268	517	12	s	s	PROPN
admet-2268	517	13	,	,	PUNCT
admet-2268	517	14	s.a	s.a	PROPN
admet-2268	517	15	.	.	PROPN
admet-2268	517	16	lewis	lewis	PROPN
admet-2268	517	17	,	,	PUNCT
admet-2268	517	18	v.m	v.m	PROPN
admet-2268	517	19	.	.	PROPN
admet-2268	517	20	ghate	ghate	PROPN
admet-2268	517	21	,	,	PUNCT
admet-2268	517	22	s.a	s.a	PROPN
admet-2268	517	23	.	.	PROPN
admet-2268	517	24	el	el	PROPN
admet-2268	517	25	-	-	PROPN
admet-2268	517	26	zahaby	zahaby	PROPN
admet-2268	517	27	,	,	PUNCT
admet-2268	517	28	s.	s.	PROPN
admet-2268	517	29	hebbar	hebbar	PROPN
admet-2268	517	30	.	.	PUNCT
admet-2268	518	1	development	development	NOUN
admet-2268	518	2	and	and	CCONJ
admet-2268	518	3	investigation	investigation	NOUN
admet-2268	518	4	of	of	ADP
admet-2268	518	5	vitamin	vitamin	NOUN
admet-2268	518	6	c	c	NOUN
admet-2268	518	7	-	-	PUNCT
admet-2268	518	8	enriched	enrich	VERB
admet-2268	518	9	adapalene	adapalene	NOUN
admet-2268	518	10	-	-	PUNCT
admet-2268	518	11	loaded	load	VERB
admet-2268	518	12	transfersome	transfersome	NOUN
admet-2268	518	13	gel	gel	NOUN
admet-2268	518	14	:	:	PUNCT
admet-2268	518	15	a	a	DET
admet-2268	518	16	collegial	collegial	ADJ
admet-2268	518	17	approach	approach	NOUN
admet-2268	518	18	for	for	ADP
admet-2268	518	19	the	the	DET
admet-2268	518	20	treatment	treatment	NOUN
admet-2268	518	21	of	of	ADP
admet-2268	518	22	acne	acne	NOUN
admet-2268	518	23	vulgaris	vulgaris	NOUN
admet-2268	518	24	.	.	PUNCT
admet-2268	519	1	aaps	aap	NOUN
admet-2268	519	2	pharmscitech	pharmscitech	VERB
admet-2268	519	3	21	21	NUM
admet-2268	519	4	(	(	PUNCT
admet-2268	519	5	2020	2020	NUM
admet-2268	519	6	)	)	PUNCT
admet-2268	519	7	61	61	NUM
admet-2268	519	8	.	.	PUNCT
admet-2268	519	9	https://doi.org/10.1208/s12249-019-1518-5	https://doi.org/10.1208/s12249-019-1518-5	PROPN
admet-2268	519	10	.	.	PUNCT
admet-2268	520	1	[	[	X
admet-2268	520	2	31	31	NUM
admet-2268	520	3	]	]	X
admet-2268	520	4	j.e	j.e	PROPN
admet-2268	520	5	.	.	PROPN
admet-2268	520	6	shaji	shaji	PROPN
admet-2268	520	7	,	,	PUNCT
admet-2268	520	8	m.a	m.a	PROPN
admet-2268	520	9	.	.	PROPN
admet-2268	520	10	lal	lal	PROPN
admet-2268	520	11	.	.	PUNCT
admet-2268	521	1	preparation	preparation	NOUN
admet-2268	521	2	,	,	PUNCT
admet-2268	521	3	optimization	optimization	NOUN
admet-2268	521	4	and	and	CCONJ
admet-2268	521	5	evaluation	evaluation	NOUN
admet-2268	521	6	of	of	ADP
admet-2268	521	7	transferosomal	transferosomal	ADJ
admet-2268	521	8	formulation	formulation	NOUN
admet-2268	521	9	for	for	ADP
admet-2268	521	10	enhanced	enhanced	ADJ
admet-2268	521	11	transdermal	transdermal	ADJ
admet-2268	521	12	delivery	delivery	NOUN
admet-2268	521	13	of	of	ADP
admet-2268	521	14	a	a	DET
admet-2268	521	15	cox-2	cox-2	ADJ
admet-2268	521	16	inhibitor	inhibitor	NOUN
admet-2268	521	17	.	.	PUNCT
admet-2268	522	1	international	international	ADJ
admet-2268	522	2	journal	journal	PROPN
admet-2268	522	3	of	of	ADP
admet-2268	522	4	pharmacy	pharmacy	NOUN
admet-2268	522	5	and	and	CCONJ
admet-2268	522	6	pharmaceutical	pharmaceutical	NOUN
admet-2268	522	7	sciences	science	NOUN
admet-2268	522	8	6(1	6(1	NUM
admet-2268	522	9	)	)	PUNCT
admet-2268	522	10	(	(	PUNCT
admet-2268	522	11	2014	2014	NUM
admet-2268	522	12	)	)	PUNCT
admet-2268	522	13	467	467	NUM
admet-2268	522	14	-	-	SYM
admet-2268	522	15	477	477	NUM
admet-2268	522	16	.	.	PUNCT
admet-2268	523	1	[	[	X
admet-2268	523	2	32	32	NUM
admet-2268	523	3	]	]	PUNCT
admet-2268	523	4	a.	a.	PROPN
admet-2268	523	5	ahad	ahad	PROPN
admet-2268	523	6	,	,	PUNCT
admet-2268	523	7	m.	m.	PROPN
admet-2268	523	8	aqil	aqil	PROPN
admet-2268	523	9	,	,	PUNCT
admet-2268	523	10	k.	k.	PROPN
admet-2268	523	11	kohli	kohli	PROPN
admet-2268	523	12	,	,	PUNCT
admet-2268	523	13	y.	y.	PROPN
admet-2268	523	14	sultana	sultana	PROPN
admet-2268	523	15	,	,	PUNCT
admet-2268	523	16	m.	m.	NOUN
admet-2268	523	17	mujeeb	mujeeb	PROPN
admet-2268	523	18	,	,	PUNCT
admet-2268	523	19	ali	ali	PROPN
admet-2268	523	20	,	,	PUNCT
admet-2268	523	21	a.	a.	NOUN
admet-2268	523	22	formulation	formulation	NOUN
admet-2268	523	23	and	and	CCONJ
admet-2268	523	24	optimization	optimization	NOUN
admet-2268	523	25	of	of	ADP
admet-2268	523	26	nanotransfersomes	nanotransfersome	NOUN
admet-2268	523	27	using	use	VERB
admet-2268	523	28	experimental	experimental	ADJ
admet-2268	523	29	design	design	NOUN
admet-2268	523	30	technique	technique	NOUN
admet-2268	523	31	for	for	ADP
admet-2268	523	32	accentuated	accentuate	VERB
admet-2268	523	33	transdermal	transdermal	ADJ
admet-2268	523	34	delivery	delivery	NOUN
admet-2268	523	35	of	of	ADP
admet-2268	523	36	valsartan	valsartan	PROPN
admet-2268	523	37	.	.	PUNCT
admet-2268	524	1	nanomedicine	nanomedicine	PROPN
admet-2268	524	2	:	:	PUNCT
admet-2268	524	3	nanotechnology	nanotechnology	NOUN
admet-2268	524	4	,	,	PUNCT
admet-2268	524	5	biology	biology	NOUN
admet-2268	524	6	and	and	CCONJ
admet-2268	524	7	medicine	medicine	NOUN
admet-2268	524	8	8(2	8(2	NUM
admet-2268	524	9	)	)	PUNCT
admet-2268	524	10	(	(	PUNCT
admet-2268	524	11	2012	2012	NUM
admet-2268	524	12	)	)	PUNCT
admet-2268	524	13	237	237	NUM
admet-2268	524	14	-	-	SYM
admet-2268	524	15	249	249	NUM
admet-2268	524	16	.	.	PUNCT
admet-2268	525	1	https://doi.org/10.1016/j.nano.2011.06.004	https://doi.org/10.1016/j.nano.2011.06.004	PROPN
admet-2268	525	2	.	.	PUNCT
admet-2268	526	1	[	[	X
admet-2268	526	2	33	33	NUM
admet-2268	526	3	]	]	PUNCT
admet-2268	526	4	s.	s.	PROPN
admet-2268	526	5	jain	jain	PROPN
admet-2268	526	6	,	,	PUNCT
admet-2268	526	7	p.	p.	PROPN
admet-2268	526	8	jain	jain	PROPN
admet-2268	526	9	,	,	PUNCT
admet-2268	526	10	r.b	r.b	PROPN
admet-2268	526	11	.	.	PROPN
admet-2268	526	12	umamaheshwari	umamaheshwari	PROPN
admet-2268	526	13	,	,	PUNCT
admet-2268	526	14	n.k	n.k	PROPN
admet-2268	526	15	.	.	PROPN
admet-2268	526	16	jain	jain	PROPN
admet-2268	526	17	.	.	PUNCT
admet-2268	527	1	transfersomes	transfersome	NOUN
admet-2268	527	2	a	a	DET
admet-2268	527	3	novel	novel	ADJ
admet-2268	527	4	vesicular	vesicular	ADJ
admet-2268	527	5	carrier	carrier	NOUN
admet-2268	527	6	for	for	ADP
admet-2268	527	7	enhanced	enhanced	ADJ
admet-2268	527	8	transdermal	transdermal	ADJ
admet-2268	527	9	delivery	delivery	NOUN
admet-2268	527	10	:	:	PUNCT
admet-2268	527	11	development	development	NOUN
admet-2268	527	12	,	,	PUNCT
admet-2268	527	13	characterization	characterization	NOUN
admet-2268	527	14	,	,	PUNCT
admet-2268	527	15	and	and	CCONJ
admet-2268	527	16	performance	performance	NOUN
admet-2268	527	17	evaluation	evaluation	NOUN
admet-2268	527	18	.	.	PUNCT
admet-2268	528	1	drug	drug	NOUN
admet-2268	528	2	development	development	NOUN
admet-2268	528	3	and	and	CCONJ
admet-2268	528	4	industrial	industrial	ADJ
admet-2268	528	5	pharmacy	pharmacy	NOUN
admet-2268	528	6	29(9	29(9	NOUN
admet-2268	528	7	)	)	PUNCT
admet-2268	528	8	(	(	PUNCT
admet-2268	528	9	2003	2003	NUM
admet-2268	528	10	)	)	PUNCT
admet-2268	528	11	1013	1013	NUM
admet-2268	528	12	-	-	SYM
admet-2268	528	13	1026	1026	NUM
admet-2268	528	14	.	.	PUNCT
admet-2268	529	1	https://doi.org/10.1081/ddc120025458	https://doi.org/10.1081/ddc120025458	NOUN
admet-2268	529	2	.	.	PUNCT
admet-2268	530	1	[	[	X
admet-2268	530	2	34	34	NUM
admet-2268	530	3	]	]	X
admet-2268	530	4	r.	r.	PROPN
admet-2268	530	5	patel	patel	PROPN
admet-2268	530	6	,	,	PUNCT
admet-2268	530	7	s.k	s.k	PROPN
admet-2268	530	8	.	.	PROPN
admet-2268	530	9	singh	singh	PROPN
admet-2268	530	10	,	,	PUNCT
admet-2268	530	11	s.	s.	PROPN
admet-2268	530	12	singh	singh	PROPN
admet-2268	530	13	,	,	PUNCT
admet-2268	530	14	n.r	n.r	PROPN
admet-2268	530	15	.	.	PROPN
admet-2268	530	16	sheth	sheth	PROPN
admet-2268	530	17	,	,	PUNCT
admet-2268	530	18	r.	r.	PROPN
admet-2268	530	19	gendle	gendle	PROPN
admet-2268	530	20	.	.	PUNCT
admet-2268	531	1	development	development	NOUN
admet-2268	531	2	and	and	CCONJ
admet-2268	531	3	characterization	characterization	NOUN
admet-2268	531	4	of	of	ADP
admet-2268	531	5	curcumin	curcumin	NOUN
admet-2268	531	6	loaded	load	VERB
admet-2268	531	7	transfersome	transfersome	NOUN
admet-2268	531	8	for	for	ADP
admet-2268	531	9	transdermal	transdermal	ADJ
admet-2268	531	10	delivery	delivery	NOUN
admet-2268	531	11	.	.	PUNCT
admet-2268	532	1	journal	journal	NOUN
admet-2268	532	2	of	of	ADP
admet-2268	532	3	pharmaceutical	pharmaceutical	NOUN
admet-2268	532	4	sciences	science	NOUN
admet-2268	532	5	and	and	CCONJ
admet-2268	532	6	research	research	NOUN
admet-2268	532	7	1(4	1(4	NUM
admet-2268	532	8	)	)	PUNCT
admet-2268	532	9	(	(	PUNCT
admet-2268	532	10	2009	2009	NUM
admet-2268	532	11	)	)	PUNCT
admet-2268	532	12	71	71	NUM
admet-2268	532	13	-	-	SYM
admet-2268	532	14	80	80	NUM
admet-2268	532	15	.	.	PUNCT
admet-2268	533	1	[	[	X
admet-2268	533	2	35	35	NUM
admet-2268	533	3	]	]	X
admet-2268	533	4	r.	r.	PROPN
admet-2268	533	5	bnyan	bnyan	PROPN
admet-2268	533	6	,	,	PUNCT
admet-2268	533	7	i.	i.	PROPN
admet-2268	533	8	khan	khan	PROPN
admet-2268	533	9	,	,	PUNCT
admet-2268	533	10	t.	t.	PROPN
admet-2268	533	11	ehtezazi	ehtezazi	PROPN
admet-2268	533	12	,	,	PUNCT
admet-2268	533	13	i.	i.	PROPN
admet-2268	533	14	saleem	saleem	PROPN
admet-2268	533	15	,	,	PUNCT
admet-2268	533	16	s.	s.	PROPN
admet-2268	533	17	gordon	gordon	PROPN
admet-2268	533	18	,	,	PUNCT
admet-2268	533	19	f.	f.	PROPN
admet-2268	533	20	o'neill	o'neill	PROPN
admet-2268	533	21	,	,	PUNCT
admet-2268	533	22	m.	m.	PROPN
admet-2268	533	23	roberts	roberts	PROPN
admet-2268	533	24	.	.	PUNCT
admet-2268	533	25	surfactant	surfactant	ADJ
admet-2268	533	26	effects	effect	NOUN
admet-2268	533	27	on	on	ADP
admet-2268	533	28	lipidbased	lipidbased	ADJ
admet-2268	533	29	vesicles	vesicle	NOUN
admet-2268	533	30	properties	property	NOUN
admet-2268	533	31	.	.	PUNCT
admet-2268	534	1	journal	journal	NOUN
admet-2268	534	2	of	of	ADP
admet-2268	534	3	pharmaceutical	pharmaceutical	PROPN
admet-2268	534	4	sciences	science	NOUN
admet-2268	534	5	107	107	NUM
admet-2268	534	6	(	(	PUNCT
admet-2268	534	7	2018	2018	NUM
admet-2268	534	8	)	)	PUNCT
admet-2268	534	9	1237	1237	NUM
admet-2268	534	10	-	-	SYM
admet-2268	534	11	1246	1246	NUM
admet-2268	534	12	.	.	PUNCT
admet-2268	535	1	https://doi.org/10.1016/j.xphs.2018.01.005	https://doi.org/10.1016/j.xphs.2018.01.005	VERB
admet-2268	535	2	.	.	PUNCT
admet-2268	536	1	[	[	X
admet-2268	536	2	36	36	NUM
admet-2268	536	3	]	]	PUNCT
admet-2268	536	4	m.	m.	NOUN
admet-2268	536	5	danaei	danaei	PROPN
admet-2268	536	6	,	,	PUNCT
admet-2268	536	7	m.	m.	NOUN
admet-2268	536	8	dehghankhold	dehghankhold	PROPN
admet-2268	536	9	,	,	PUNCT
admet-2268	536	10	s.	s.	PROPN
admet-2268	536	11	ataei	ataei	PROPN
admet-2268	536	12	,	,	PUNCT
admet-2268	536	13	f.	f.	PROPN
admet-2268	536	14	hasanzadeh	hasanzadeh	PROPN
admet-2268	536	15	davarani	davarani	PROPN
admet-2268	536	16	,	,	PUNCT
admet-2268	536	17	r.	r.	PROPN
admet-2268	536	18	javanmard	javanmard	PROPN
admet-2268	536	19	,	,	PUNCT
admet-2268	536	20	a.	a.	PROPN
admet-2268	536	21	dokhani	dokhani	PROPN
admet-2268	536	22	,	,	PUNCT
admet-2268	536	23	s.	s.	PROPN
admet-2268	536	24	khorasani	khorasani	PROPN
admet-2268	536	25	,	,	PUNCT
admet-2268	536	26	m.r	m.r	PROPN
admet-2268	536	27	.	.	PROPN
admet-2268	536	28	mozafari	mozafari	PROPN
admet-2268	536	29	.	.	PUNCT
admet-2268	537	1	impact	impact	NOUN
admet-2268	537	2	of	of	ADP
admet-2268	537	3	particle	particle	NOUN
admet-2268	537	4	size	size	NOUN
admet-2268	537	5	and	and	CCONJ
admet-2268	537	6	polydispersity	polydispersity	NOUN
admet-2268	537	7	index	index	NOUN
admet-2268	537	8	on	on	ADP
admet-2268	537	9	the	the	DET
admet-2268	537	10	clinical	clinical	ADJ
admet-2268	537	11	applications	application	NOUN
admet-2268	537	12	of	of	ADP
admet-2268	537	13	lipidic	lipidic	ADJ
admet-2268	537	14	nanocarrier	nanocarrier	PROPN
admet-2268	537	15	systems	systems	PROPN
admet-2268	537	16	.	.	PUNCT
admet-2268	538	1	pharmaceutics	pharmaceutic	NOUN
admet-2268	538	2	10	10	NUM
admet-2268	538	3	(	(	PUNCT
admet-2268	538	4	2018	2018	NUM
admet-2268	538	5	)	)	PUNCT
admet-2268	538	6	57	57	NUM
admet-2268	538	7	.	.	PUNCT
admet-2268	538	8	https://doi.org/10.3390/pharmaceutics10020057	https://doi.org/10.3390/pharmaceutics10020057	NOUN
admet-2268	538	9	.	.	PUNCT
admet-2268	539	1	[	[	X
admet-2268	539	2	37	37	NUM
admet-2268	539	3	]	]	PUNCT
admet-2268	539	4	p.	p.	PROPN
admet-2268	539	5	liu	liu	PROPN
admet-2268	539	6	,	,	PUNCT
admet-2268	539	7	g.	g.	PROPN
admet-2268	539	8	chen	chen	PROPN
admet-2268	539	9	,	,	PUNCT
admet-2268	539	10	j.	j.	PROPN
admet-2268	539	11	zhang	zhang	PROPN
admet-2268	539	12	.	.	PUNCT
admet-2268	540	1	a	a	DET
admet-2268	540	2	review	review	NOUN
admet-2268	540	3	of	of	ADP
admet-2268	540	4	liposomes	liposome	NOUN
admet-2268	540	5	as	as	ADP
admet-2268	540	6	a	a	DET
admet-2268	540	7	drug	drug	NOUN
admet-2268	540	8	delivery	delivery	NOUN
admet-2268	540	9	system	system	NOUN
admet-2268	540	10	:	:	PUNCT
admet-2268	540	11	current	current	ADJ
admet-2268	540	12	status	status	NOUN
admet-2268	540	13	of	of	ADP
admet-2268	540	14	approved	approve	VERB
admet-2268	540	15	products	product	NOUN
admet-2268	540	16	,	,	PUNCT
admet-2268	540	17	regulatory	regulatory	ADJ
admet-2268	540	18	environments	environment	NOUN
admet-2268	540	19	,	,	PUNCT
admet-2268	540	20	and	and	CCONJ
admet-2268	540	21	future	future	ADJ
admet-2268	540	22	perspectives	perspective	NOUN
admet-2268	540	23	.	.	PUNCT
admet-2268	541	1	molecules	molecule	NOUN
admet-2268	541	2	27	27	NUM
admet-2268	541	3	(	(	PUNCT
admet-2268	541	4	2022	2022	NUM
admet-2268	541	5	)	)	PUNCT
admet-2268	541	6	1372	1372	NUM
admet-2268	541	7	.	.	PUNCT
admet-2268	542	1	https://doi.org/10.3390/molecules27041372	https://doi.org/10.3390/molecules27041372	PROPN
admet-2268	542	2	.	.	PUNCT
admet-2268	543	1	[	[	X
admet-2268	543	2	38	38	NUM
admet-2268	543	3	]	]	X
admet-2268	543	4	m.d	m.d	PROPN
admet-2268	543	5	.	.	PROPN
admet-2268	543	6	ansari	ansari	PROPN
admet-2268	543	7	,	,	PUNCT
admet-2268	543	8	z.	z.	PROPN
admet-2268	543	9	saifi	saifi	PROPN
admet-2268	543	10	,	,	PUNCT
admet-2268	543	11	j.	j.	PROPN
admet-2268	543	12	pandit	pandit	PROPN
admet-2268	543	13	,	,	PUNCT
admet-2268	543	14	i.	i.	PROPN
admet-2268	543	15	khan	khan	PROPN
admet-2268	543	16	,	,	PUNCT
admet-2268	543	17	p.	p.	PROPN
admet-2268	543	18	solanki	solanki	PROPN
admet-2268	543	19	,	,	PUNCT
admet-2268	543	20	y.	y.	PROPN
admet-2268	543	21	sultana	sultana	PROPN
admet-2268	543	22	,	,	PUNCT
admet-2268	543	23	m.	m.	PROPN
admet-2268	543	24	aqil	aqil	PROPN
admet-2268	543	25	.	.	PUNCT
admet-2268	544	1	spanlastics	spanlastic	NOUN
admet-2268	544	2	a	a	DET
admet-2268	544	3	novel	novel	ADJ
admet-2268	544	4	nanovesicular	nanovesicular	ADJ
admet-2268	544	5	carrier	carrier	NOUN
admet-2268	544	6	:	:	PUNCT
admet-2268	544	7	its	its	PRON
admet-2268	544	8	potential	potential	ADJ
admet-2268	544	9	application	application	NOUN
admet-2268	544	10	and	and	CCONJ
admet-2268	544	11	emerging	emerge	VERB
admet-2268	544	12	trends	trend	NOUN
admet-2268	544	13	in	in	ADP
admet-2268	544	14	therapeutic	therapeutic	ADJ
admet-2268	544	15	delivery	delivery	NOUN
admet-2268	544	16	.	.	PUNCT
admet-2268	545	1	aaps	aap	NOUN
admet-2268	545	2	pharmscitech	pharmscitech	VERB
admet-2268	545	3	23	23	NUM
admet-2268	545	4	(	(	PUNCT
admet-2268	545	5	2022	2022	NUM
admet-2268	545	6	)	)	PUNCT
admet-2268	545	7	112	112	NUM
admet-2268	545	8	.	.	PUNCT
admet-2268	546	1	https://doi.org/10.1208/s12249-022-02217-9	https://doi.org/10.1208/s12249-022-02217-9	NOUN
admet-2268	546	2	.	.	PUNCT
admet-2268	547	1	[	[	X
admet-2268	547	2	39	39	NUM
admet-2268	547	3	]	]	PUNCT
admet-2268	547	4	d.	d.	PROPN
admet-2268	547	5	choudhury	choudhury	PROPN
admet-2268	547	6	,	,	PUNCT
admet-2268	547	7	a.	a.	PROPN
admet-2268	547	8	jala	jala	PROPN
admet-2268	547	9	,	,	PUNCT
admet-2268	547	10	u.s	u.s	PROPN
admet-2268	547	11	.	.	PROPN
admet-2268	547	12	murty	murty	PROPN
admet-2268	547	13	,	,	PUNCT
admet-2268	547	14	r.m	r.m	PROPN
admet-2268	547	15	.	.	PROPN
admet-2268	547	16	borkar	borkar	PROPN
admet-2268	547	17	,	,	PUNCT
admet-2268	547	18	s.	s.	PROPN
admet-2268	547	19	banerjee	banerjee	PROPN
admet-2268	547	20	.	.	PUNCT
admet-2268	548	1	in	in	ADP
admet-2268	548	2	vitro	vitro	X
admet-2268	548	3	and	and	CCONJ
admet-2268	548	4	ex	ex	PRON
admet-2268	548	5	evaluations	evaluation	NOUN
admet-2268	548	6	of	of	ADP
admet-2268	548	7	berberineloaded	berberineloade	VERB
admet-2268	548	8	microparticles	microparticle	NOUN
admet-2268	548	9	filled	fill	VERB
admet-2268	548	10	in	in	ADP
admet-2268	548	11	-	-	PUNCT
admet-2268	548	12	house	house	NOUN
admet-2268	548	13	3d	3d	NOUN
admet-2268	548	14	printed	print	VERB
admet-2268	548	15	hollow	hollow	ADJ
admet-2268	548	16	capsular	capsular	NOUN
admet-2268	548	17	device	device	NOUN
admet-2268	548	18	for	for	ADP
admet-2268	548	19	improved	improved	ADJ
admet-2268	548	20	oral	oral	ADJ
admet-2268	548	21	bioavailability	bioavailability	NOUN
admet-2268	548	22	.	.	PUNCT
admet-2268	549	1	aaps	aap	NOUN
admet-2268	549	2	pharmscitech	pharmscitech	VERB
admet-2268	549	3	23	23	NUM
admet-2268	549	4	(	(	PUNCT
admet-2268	549	5	2022	2022	NUM
admet-2268	549	6	)	)	PUNCT
admet-2268	549	7	89	89	NUM
admet-2268	549	8	.	.	PUNCT
admet-2268	549	9	https://doi.org/10.1208/s12249-022-02241-9	https://doi.org/10.1208/s12249-022-02241-9	NUM
admet-2268	549	10	.	.	PUNCT
admet-2268	550	1	[	[	X
admet-2268	550	2	40	40	NUM
admet-2268	550	3	]	]	X
admet-2268	550	4	m.u.k	m.u.k	PROPN
admet-2268	550	5	.	.	PUNCT
admet-2268	550	6	sahibzada	sahibzada	PROPN
admet-2268	550	7	,	,	PUNCT
admet-2268	550	8	a.	a.	PROPN
admet-2268	550	9	sadiq	sadiq	PROPN
admet-2268	550	10	,	,	PUNCT
admet-2268	550	11	h.s	h.s	PROPN
admet-2268	550	12	.	.	PROPN
admet-2268	550	13	faidah	faidah	PROPN
admet-2268	550	14	,	,	PUNCT
admet-2268	550	15	m.	m.	NOUN
admet-2268	550	16	khurram	khurram	PROPN
admet-2268	550	17	,	,	PUNCT
admet-2268	550	18	m.u	m.u	PROPN
admet-2268	550	19	.	.	PROPN
admet-2268	550	20	amin	amin	PROPN
admet-2268	550	21	,	,	PUNCT
admet-2268	550	22	a.	a.	NOUN
admet-2268	550	23	haseeb	haseeb	PROPN
admet-2268	550	24	,	,	PUNCT
admet-2268	550	25	m.	m.	NOUN
admet-2268	550	26	kakar	kakar	PROPN
admet-2268	550	27	.	.	PUNCT
admet-2268	551	1	berberine	berberine	NOUN
admet-2268	551	2	nanoparticles	nanoparticle	NOUN
admet-2268	551	3	with	with	ADP
admet-2268	551	4	enhanced	enhance	VERB
admet-2268	551	5	in	in	ADP
admet-2268	551	6	vitro	vitro	X
admet-2268	551	7	bioavailability	bioavailability	NOUN
admet-2268	551	8	:	:	PUNCT
admet-2268	551	9	characterization	characterization	NOUN
admet-2268	551	10	and	and	CCONJ
admet-2268	551	11	antimicrobial	antimicrobial	ADJ
admet-2268	551	12	activity	activity	NOUN
admet-2268	551	13	.	.	PUNCT
admet-2268	552	1	drug	drug	NOUN
admet-2268	552	2	design	design	NOUN
admet-2268	552	3	,	,	PUNCT
admet-2268	552	4	development	development	NOUN
admet-2268	552	5	and	and	CCONJ
admet-2268	552	6	therapy	therapy	NOUN
admet-2268	552	7	12	12	NUM
admet-2268	552	8	(	(	PUNCT
admet-2268	552	9	2018	2018	NUM
admet-2268	552	10	)	)	PUNCT
admet-2268	552	11	303	303	NUM
admet-2268	552	12	-	-	SYM
admet-2268	552	13	312	312	NUM
admet-2268	552	14	.	.	PUNCT
admet-2268	553	1	https://doi.org/10.2147/dddt.s156123	https://doi.org/10.2147/dddt.s156123	NOUN
admet-2268	553	2	.	.	PUNCT
admet-2268	554	1	[	[	X
admet-2268	554	2	41	41	NUM
admet-2268	554	3	]	]	X
admet-2268	554	4	s.k	s.k	PROPN
admet-2268	554	5	.	.	PROPN
admet-2268	554	6	battu	battu	PROPN
admet-2268	554	7	,	,	PUNCT
admet-2268	554	8	m.a	m.a	PROPN
admet-2268	554	9	.	.	PROPN
admet-2268	554	10	repka	repka	PROPN
admet-2268	554	11	,	,	PUNCT
admet-2268	554	12	s.	s.	PROPN
admet-2268	554	13	maddineni	maddineni	PROPN
admet-2268	554	14	,	,	PUNCT
admet-2268	554	15	a.g	a.g	PROPN
admet-2268	554	16	.	.	PROPN
admet-2268	554	17	chittiboyina	chittiboyina	PROPN
admet-2268	554	18	,	,	PUNCT
admet-2268	554	19	m.a	m.a	PROPN
admet-2268	554	20	.	.	PROPN
admet-2268	554	21	avery	avery	PROPN
admet-2268	554	22	,	,	PUNCT
admet-2268	554	23	s.	s.	PROPN
admet-2268	554	24	majumdar	majumdar	PROPN
admet-2268	554	25	.	.	PUNCT
admet-2268	555	1	physicochemical	physicochemical	ADJ
admet-2268	555	2	characterization	characterization	NOUN
admet-2268	555	3	of	of	ADP
admet-2268	555	4	berberine	berberine	NOUN
admet-2268	555	5	chloride	chloride	NOUN
admet-2268	555	6	:	:	PUNCT
admet-2268	555	7	a	a	DET
admet-2268	555	8	perspective	perspective	NOUN
admet-2268	555	9	in	in	ADP
admet-2268	555	10	the	the	DET
admet-2268	555	11	development	development	NOUN
admet-2268	555	12	of	of	ADP
admet-2268	555	13	a	a	DET
admet-2268	555	14	solution	solution	NOUN
admet-2268	555	15	dosage	dosage	NOUN
admet-2268	555	16	form	form	NOUN
admet-2268	555	17	for	for	ADP
admet-2268	555	18	oral	oral	ADJ
admet-2268	555	19	delivery	delivery	NOUN
admet-2268	555	20	.	.	PUNCT
admet-2268	556	1	aaps	aap	NOUN
admet-2268	556	2	pharmscitech	pharmscitech	VERB
admet-2268	556	3	11	11	NUM
admet-2268	556	4	(	(	PUNCT
admet-2268	556	5	2010	2010	NUM
admet-2268	556	6	)	)	PUNCT
admet-2268	556	7	1466	1466	NUM
admet-2268	556	8	-	-	SYM
admet-2268	556	9	75	75	NUM
admet-2268	556	10	.	.	PUNCT
admet-2268	557	1	https://doi.org/10.1208/s12249-010-9520-y	https://doi.org/10.1208/s12249-010-9520-y	ADJ
admet-2268	557	2	.	.	PUNCT
admet-2268	558	1	[	[	X
admet-2268	558	2	42	42	NUM
admet-2268	558	3	]	]	PUNCT
admet-2268	558	4	z.	z.	PROPN
admet-2268	558	5	yan	yan	PROPN
admet-2268	558	6	,	,	PUNCT
admet-2268	558	7	m.	m.	NOUN
admet-2268	558	8	sun	sun	PROPN
admet-2268	558	9	,	,	PUNCT
admet-2268	558	10	y.	y.	PROPN
admet-2268	558	11	lv	lv	PROPN
admet-2268	558	12	.	.	PUNCT
admet-2268	558	13	novel	novel	PROPN
admet-2268	558	14	berberine	berberine	NOUN
admet-2268	558	15	-	-	PUNCT
admet-2268	558	16	based	base	VERB
admet-2268	558	17	pharmaceutical	pharmaceutical	ADJ
admet-2268	558	18	salts	salt	NOUN
admet-2268	558	19	with	with	ADP
admet-2268	558	20	fatty	fatty	NOUN
admet-2268	558	21	acid	acid	NOUN
admet-2268	558	22	anions	anion	NOUN
admet-2268	558	23	:	:	PUNCT
admet-2268	558	24	synthesis	synthesis	NOUN
admet-2268	558	25	,	,	PUNCT
admet-2268	558	26	characterization	characterization	NOUN
admet-2268	558	27	,	,	PUNCT
admet-2268	558	28	physicochemical	physicochemical	ADJ
admet-2268	558	29	properties	property	NOUN
admet-2268	558	30	.	.	PUNCT
admet-2268	559	1	journal	journal	NOUN
admet-2268	559	2	of	of	ADP
admet-2268	559	3	molecular	molecular	ADJ
admet-2268	559	4	liquids	liquid	NOUN
admet-2268	559	5	360	360	NUM
admet-2268	559	6	(	(	PUNCT
admet-2268	559	7	2022	2022	NUM
admet-2268	559	8	)	)	PUNCT
admet-2268	559	9	119397	119397	NUM
admet-2268	559	10	.	.	PUNCT
admet-2268	560	1	https://doi.org/10.1016/j.molliq.2022.119397	https://doi.org/10.1016/j.molliq.2022.119397	NOUN
admet-2268	560	2	.	.	PUNCT
admet-2268	561	1	[	[	X
admet-2268	561	2	43	43	NUM
admet-2268	561	3	]	]	X
admet-2268	561	4	a.a	a.a	PROPN
admet-2268	561	5	.	.	PROPN
admet-2268	561	6	eltobshi	eltobshi	PROPN
admet-2268	561	7	,	,	PUNCT
admet-2268	561	8	e.a	e.a	PROPN
admet-2268	561	9	.	.	PROPN
admet-2268	561	10	mohamed	mohamed	PROPN
admet-2268	561	11	,	,	PUNCT
admet-2268	561	12	g.m	g.m	PROPN
admet-2268	561	13	.	.	PROPN
admet-2268	561	14	abdelghani	abdelghani	PROPN
admet-2268	561	15	,	,	PUNCT
admet-2268	561	16	a.t	a.t	PROPN
admet-2268	561	17	.	.	PROPN
admet-2268	561	18	nouh	nouh	PROPN
admet-2268	561	19	.	.	PUNCT
admet-2268	562	1	self	self	NOUN
admet-2268	562	2	-	-	PUNCT
admet-2268	562	3	nanoemulsifying	nanoemulsifye	VERB
admet-2268	562	4	drug	drug	NOUN
admet-2268	562	5	-	-	PUNCT
admet-2268	562	6	delivery	delivery	NOUN
admet-2268	562	7	systems	system	NOUN
admet-2268	562	8	for	for	ADP
admet-2268	562	9	potentiated	potentiate	VERB
admet-2268	562	10	anti	anti	ADJ
admet-2268	562	11	-	-	ADJ
admet-2268	562	12	inflammatory	inflammatory	ADJ
admet-2268	562	13	activity	activity	NOUN
admet-2268	562	14	of	of	ADP
admet-2268	562	15	diacerein	diacerein	ADJ
admet-2268	562	16	.	.	PUNCT
admet-2268	563	1	international	international	ADJ
admet-2268	563	2	journal	journal	PROPN
admet-2268	563	3	of	of	ADP
admet-2268	563	4	nanomedicine	nanomedicine	NOUN
admet-2268	563	5	18	18	NUM
admet-2268	563	6	(	(	PUNCT
admet-2268	563	7	2018	2018	NUM
admet-2268	563	8	)	)	PUNCT
admet-2268	563	9	6585	6585	NUM
admet-2268	563	10	-	-	SYM
admet-2268	563	11	6602	6602	NUM
admet-2268	563	12	.	.	PUNCT
admet-2268	564	1	https://doi.org/10.2147/ijn.s178819	https://doi.org/10.2147/ijn.s178819	NOUN
admet-2268	564	2	.	.	PUNCT
admet-2268	565	1	https://doi.org/10.3390/pharmaceutics10010026	https://doi.org/10.3390/pharmaceutics10010026	PROPN
admet-2268	565	2	https://doi.org/10.1208/s12249-019-1518-5	https://doi.org/10.1208/s12249-019-1518-5	PROPN
admet-2268	565	3	https://doi.org/10.1016/j.nano.2011.06.004	https://doi.org/10.1016/j.nano.2011.06.004	VERB
admet-2268	565	4	https://doi.org/10.1081/ddc-120025458	https://doi.org/10.1081/ddc-120025458	PROPN
admet-2268	565	5	https://doi.org/10.1081/ddc-120025458	https://doi.org/10.1081/ddc-120025458	PROPN
admet-2268	565	6	https://doi.org/10.1016/j.xphs.2018.01.005	https://doi.org/10.1016/j.xphs.2018.01.005	NUM
admet-2268	565	7	https://doi.org/10.3390/pharmaceutics10020057	https://doi.org/10.3390/pharmaceutics10020057	NOUN
admet-2268	565	8	https://doi.org/10.3390/molecules27041372	https://doi.org/10.3390/molecules27041372	PROPN
admet-2268	565	9	https://doi.org/10.1208/s12249-022-02217-9	https://doi.org/10.1208/s12249-022-02217-9	NUM
admet-2268	565	10	https://doi.org/10.1208/s12249-022-02241-9	https://doi.org/10.1208/s12249-022-02241-9	NUM
admet-2268	565	11	https://doi.org/10.2147/dddt.s156123	https://doi.org/10.2147/dddt.s156123	VERB
admet-2268	565	12	https://doi.org/10.1208/s12249-010-9520-y	https://doi.org/10.1208/s12249-010-9520-y	PROPN
admet-2268	565	13	https://doi.org/10.1016/j.molliq.2022.119397	https://doi.org/10.1016/j.molliq.2022.119397	PROPN
admet-2268	565	14	https://doi.org/10.2147/ijn.s178819	https://doi.org/10.2147/ijn.s178819	NOUN
admet-2268	565	15	admet	admet	PROPN
admet-2268	565	16	&	&	CCONJ
admet-2268	565	17	dmpk	dmpk	PROPN
admet-2268	565	18	12(3	12(3	PROPN
admet-2268	565	19	)	)	PUNCT
admet-2268	565	20	(	(	PUNCT
admet-2268	565	21	2024	2024	NUM
admet-2268	565	22	)	)	PUNCT
admet-2268	565	23	553	553	NUM
admet-2268	565	24	-	-	SYM
admet-2268	565	25	580	580	NUM
admet-2268	565	26	berberine	berberine	NOUN
admet-2268	565	27	hcl	hcl	PROPN
admet-2268	565	28	and	and	CCONJ
admet-2268	565	29	diacerein	diacerein	ADV
admet-2268	565	30	loaded	load	VERB
admet-2268	565	31	dual	dual	ADJ
admet-2268	565	32	delivery	delivery	NOUN
admet-2268	565	33	transferosomes	transferosome	NOUN
admet-2268	565	34	doi	doi	PROPN
admet-2268	565	35	:	:	PUNCT
admet-2268	565	36	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	565	37	579	579	NUM
admet-2268	565	38	[	[	X
admet-2268	565	39	44	44	NUM
admet-2268	565	40	]	]	SYM
admet-2268	565	41	m.i	m.i	PROPN
admet-2268	565	42	.	.	PROPN
admet-2268	565	43	khan	khan	PROPN
admet-2268	565	44	,	,	PUNCT
admet-2268	565	45	a.	a.	NOUN
admet-2268	565	46	madni	madni	PROPN
admet-2268	565	47	,	,	PUNCT
admet-2268	565	48	j.	j.	PROPN
admet-2268	565	49	hirvonen	hirvonen	PROPN
admet-2268	565	50	,	,	PUNCT
admet-2268	565	51	l.	l.	PROPN
admet-2268	565	52	peltonen	peltonen	PROPN
admet-2268	565	53	.	.	PUNCT
admet-2268	566	1	ultrasonic	ultrasonic	ADJ
admet-2268	566	2	processing	processing	NOUN
admet-2268	566	3	technique	technique	NOUN
admet-2268	566	4	as	as	ADP
admet-2268	566	5	a	a	DET
admet-2268	566	6	green	green	ADJ
admet-2268	566	7	preparation	preparation	NOUN
admet-2268	566	8	approach	approach	NOUN
admet-2268	566	9	for	for	ADP
admet-2268	566	10	diacerein	diacerein	ADV
admet-2268	566	11	-	-	PUNCT
admet-2268	566	12	loaded	load	VERB
admet-2268	566	13	niosomes	niosome	NOUN
admet-2268	566	14	.	.	PUNCT
admet-2268	567	1	aaps	aap	NOUN
admet-2268	567	2	pharmscitech	pharmscitech	VERB
admet-2268	567	3	18	18	NUM
admet-2268	567	4	(	(	PUNCT
admet-2268	567	5	2017	2017	NUM
admet-2268	567	6	)	)	PUNCT
admet-2268	567	7	1554	1554	NUM
admet-2268	567	8	-	-	SYM
admet-2268	567	9	1563	1563	NUM
admet-2268	567	10	.	.	PUNCT
admet-2268	568	1	https://doi.org/10.1208/s12249-016-0622-z	https://doi.org/10.1208/s12249-016-0622-z	NOUN
admet-2268	568	2	.	.	PUNCT
admet-2268	569	1	[	[	X
admet-2268	569	2	45	45	NUM
admet-2268	569	3	]	]	X
admet-2268	569	4	d.	d.	PROPN
admet-2268	569	5	kesharwani	kesharwani	PROPN
admet-2268	569	6	,	,	PUNCT
admet-2268	569	7	s.d	s.d	PROPN
admet-2268	569	8	.	.	PROPN
admet-2268	569	9	paul	paul	PROPN
admet-2268	569	10	,	,	PUNCT
admet-2268	569	11	r.	r.	PROPN
admet-2268	569	12	paliwal	paliwal	NOUN
admet-2268	569	13	,	,	PUNCT
admet-2268	569	14	t.	t.	PROPN
admet-2268	569	15	satapathy	satapathy	ADJ
admet-2268	569	16	.	.	PUNCT
admet-2268	569	17	development	development	NOUN
admet-2268	569	18	,	,	PUNCT
admet-2268	569	19	qbd	qbd	PROPN
admet-2268	569	20	based	base	VERB
admet-2268	569	21	optimization	optimization	NOUN
admet-2268	569	22	and	and	CCONJ
admet-2268	569	23	in	in	ADP
admet-2268	569	24	vitro	vitro	X
admet-2268	569	25	characterization	characterization	NOUN
admet-2268	569	26	of	of	ADP
admet-2268	569	27	diacerein	diacerein	ADV
admet-2268	569	28	loaded	load	VERB
admet-2268	569	29	nanostructured	nanostructure	VERB
admet-2268	569	30	lipid	lipid	NOUN
admet-2268	569	31	carriers	carrier	NOUN
admet-2268	569	32	for	for	ADP
admet-2268	569	33	topical	topical	ADJ
admet-2268	569	34	applications	application	NOUN
admet-2268	569	35	.	.	PUNCT
admet-2268	570	1	journal	journal	NOUN
admet-2268	570	2	of	of	ADP
admet-2268	570	3	radiation	radiation	NOUN
admet-2268	570	4	research	research	NOUN
admet-2268	570	5	and	and	CCONJ
admet-2268	570	6	applied	apply	VERB
admet-2268	570	7	sciences	science	NOUN
admet-2268	570	8	16(2	16(2	NUM
admet-2268	570	9	)	)	PUNCT
admet-2268	570	10	(	(	PUNCT
admet-2268	570	11	2023	2023	NUM
admet-2268	570	12	)	)	PUNCT
admet-2268	570	13	100565	100565	NUM
admet-2268	570	14	.	.	PUNCT
admet-2268	571	1	https://doi.org/10.1016/j.jrras.2023.100565	https://doi.org/10.1016/j.jrras.2023.100565	ADV
admet-2268	571	2	.	.	PUNCT
admet-2268	572	1	[	[	X
admet-2268	572	2	46	46	NUM
admet-2268	572	3	]	]	X
admet-2268	572	4	b.k	b.k	PROPN
admet-2268	572	5	.	.	PROPN
admet-2268	572	6	ghyadh	ghyadh	PROPN
admet-2268	572	7	,	,	PUNCT
admet-2268	572	8	e.	e.	PROPN
admet-2268	572	9	al	al	PROPN
admet-2268	572	10	-	-	PUNCT
admet-2268	572	11	khedairy	khedairy	PROPN
admet-2268	572	12	.	.	PUNCT
admet-2268	572	13	solubility	solubility	NOUN
admet-2268	572	14	and	and	CCONJ
admet-2268	572	15	dissolution	dissolution	NOUN
admet-2268	572	16	enhancement	enhancement	NOUN
admet-2268	572	17	of	of	ADP
admet-2268	572	18	atorvastatin	atorvastatin	PROPN
admet-2268	572	19	calcium	calcium	NOUN
admet-2268	572	20	using	use	VERB
admet-2268	572	21	phospholipid	phospholipid	NOUN
admet-2268	572	22	solid	solid	ADJ
admet-2268	572	23	dispersion	dispersion	NOUN
admet-2268	572	24	technique	technique	NOUN
admet-2268	572	25	.	.	PUNCT
admet-2268	573	1	iraqi	iraqi	ADJ
admet-2268	573	2	journal	journal	PROPN
admet-2268	573	3	of	of	ADP
admet-2268	573	4	pharmaceutical	pharmaceutical	ADJ
admet-2268	573	5	sciences	science	NOUN
admet-2268	573	6	32	32	NUM
admet-2268	573	7	(	(	PUNCT
admet-2268	573	8	2023	2023	NUM
admet-2268	573	9	)	)	PUNCT
admet-2268	573	10	244	244	NUM
admet-2268	573	11	-	-	SYM
admet-2268	573	12	253	253	NUM
admet-2268	573	13	.	.	PUNCT
admet-2268	574	1	https://doi.org/10.31351/vol32isssuppl.pp244-253	https://doi.org/10.31351/vol32isssuppl.pp244-253	X
admet-2268	574	2	.	.	PUNCT
admet-2268	575	1	[	[	X
admet-2268	575	2	47	47	NUM
admet-2268	575	3	]	]	X
admet-2268	575	4	y.s	y.s	PROPN
admet-2268	575	5	.	.	PROPN
admet-2268	575	6	hsieh	hsieh	PROPN
admet-2268	575	7	,	,	PUNCT
admet-2268	575	8	y.f	y.f	PROPN
admet-2268	575	9	.	.	PUNCT
admet-2268	576	1	chen	chen	PROPN
admet-2268	576	2	,	,	PUNCT
admet-2268	576	3	y.y	y.y	PROPN
admet-2268	576	4	.	.	PROPN
admet-2268	576	5	cheng	cheng	PROPN
admet-2268	576	6	,	,	PUNCT
admet-2268	577	1	w.y	w.y	PROPN
admet-2268	577	2	.	.	PUNCT
admet-2268	578	1	liu	liu	PROPN
admet-2268	578	2	,	,	PUNCT
admet-2268	578	3	y.t	y.t	PROPN
admet-2268	578	4	.	.	PROPN
admet-2268	578	5	wu	wu	PROPN
admet-2268	578	6	.	.	PUNCT
admet-2268	579	1	self	self	NOUN
admet-2268	579	2	-	-	PUNCT
admet-2268	579	3	emulsifying	emulsify	VERB
admet-2268	579	4	phospholipid	phospholipid	NOUN
admet-2268	579	5	preconcentrates	preconcentrate	NOUN
admet-2268	579	6	for	for	ADP
admet-2268	579	7	the	the	DET
admet-2268	579	8	enhanced	enhanced	ADJ
admet-2268	579	9	photoprotection	photoprotection	NOUN
admet-2268	579	10	of	of	ADP
admet-2268	579	11	luteolin	luteolin	PROPN
admet-2268	579	12	.	.	PUNCT
admet-2268	580	1	pharmaceutics	pharmaceutic	NOUN
admet-2268	580	2	14(9	14(9	NUM
admet-2268	580	3	)	)	PUNCT
admet-2268	580	4	(	(	PUNCT
admet-2268	580	5	2022	2022	NUM
admet-2268	580	6	)	)	PUNCT
admet-2268	580	7	1896	1896	NUM
admet-2268	580	8	.	.	PUNCT
admet-2268	581	1	https://doi.org/10.3390/pharmaceutics14091896	https://doi.org/10.3390/pharmaceutics14091896	NOUN
admet-2268	581	2	.	.	PUNCT
admet-2268	582	1	[	[	X
admet-2268	582	2	48	48	NUM
admet-2268	582	3	]	]	PUNCT
admet-2268	582	4	q.	q.	PROPN
admet-2268	582	5	zhao	zhao	PROPN
admet-2268	582	6	,	,	PUNCT
admet-2268	582	7	x.	x.	PROPN
admet-2268	582	8	liu	liu	PROPN
admet-2268	582	9	,	,	PUNCT
admet-2268	582	10	s.	s.	PROPN
admet-2268	582	11	veldhuis	veldhuis	PROPN
admet-2268	582	12	,	,	PUNCT
admet-2268	582	13	i.	i.	PROPN
admet-2268	582	14	zhitomirsky	zhitomirsky	PROPN
admet-2268	582	15	.	.	PUNCT
admet-2268	583	1	sodium	sodium	NOUN
admet-2268	583	2	deoxycholate	deoxycholate	VERB
admet-2268	583	3	as	as	ADP
admet-2268	583	4	a	a	DET
admet-2268	583	5	versatile	versatile	ADJ
admet-2268	583	6	dispersing	dispersing	NOUN
admet-2268	583	7	and	and	CCONJ
admet-2268	583	8	coatingforming	coatingforme	VERB
admet-2268	583	9	agent	agent	NOUN
admet-2268	583	10	:	:	PUNCT
admet-2268	583	11	a	a	DET
admet-2268	583	12	new	new	ADJ
admet-2268	583	13	facet	facet	NOUN
admet-2268	583	14	of	of	ADP
admet-2268	583	15	electrophoretic	electrophoretic	ADJ
admet-2268	583	16	deposition	deposition	NOUN
admet-2268	583	17	technology	technology	NOUN
admet-2268	583	18	.	.	PUNCT
admet-2268	584	1	colloids	colloid	NOUN
admet-2268	584	2	and	and	CCONJ
admet-2268	584	3	surfaces	surface	NOUN
admet-2268	584	4	a	a	DET
admet-2268	584	5	:	:	PUNCT
admet-2268	584	6	physicochemical	physicochemical	ADJ
admet-2268	584	7	and	and	CCONJ
admet-2268	584	8	engineering	engineering	NOUN
admet-2268	584	9	aspects	aspect	NOUN
admet-2268	584	10	588	588	NUM
admet-2268	584	11	(	(	PUNCT
admet-2268	584	12	2020	2020	NUM
admet-2268	584	13	)	)	PUNCT
admet-2268	584	14	124382	124382	NUM
admet-2268	584	15	.	.	PUNCT
admet-2268	585	1	https://doi.org/10.1016/j.colsurfa.2019.124382	https://doi.org/10.1016/j.colsurfa.2019.124382	PROPN
admet-2268	585	2	.	.	PUNCT
admet-2268	586	1	[	[	X
admet-2268	586	2	49	49	NUM
admet-2268	586	3	]	]	PUNCT
admet-2268	586	4	s.	s.	PROPN
admet-2268	586	5	sun	sun	PROPN
admet-2268	586	6	,	,	PUNCT
admet-2268	586	7	n.a	n.a	PROPN
admet-2268	586	8	.	.	PROPN
admet-2268	586	9	liang	liang	PROPN
admet-2268	586	10	,	,	PUNCT
admet-2268	586	11	y.	y.	PROPN
admet-2268	586	12	kawashima	kawashima	PROPN
admet-2268	586	13	,	,	PUNCT
admet-2268	586	14	d.	d.	PROPN
admet-2268	586	15	xia	xia	PROPN
admet-2268	586	16	,	,	PUNCT
admet-2268	586	17	f.	f.	PROPN
admet-2268	586	18	cui	cui	PROPN
admet-2268	586	19	.	.	PUNCT
admet-2268	586	20	hydrophobic	hydrophobic	NOUN
admet-2268	586	21	ion	ion	NOUN
admet-2268	586	22	pairing	pairing	NOUN
admet-2268	586	23	of	of	ADP
admet-2268	586	24	an	an	DET
admet-2268	586	25	insulin	insulin	NOUN
admet-2268	586	26	-	-	PUNCT
admet-2268	586	27	sodium	sodium	NOUN
admet-2268	586	28	deoxycholate	deoxycholate	ADJ
admet-2268	586	29	complex	complex	NOUN
admet-2268	586	30	for	for	ADP
admet-2268	586	31	oral	oral	ADJ
admet-2268	586	32	delivery	delivery	NOUN
admet-2268	586	33	of	of	ADP
admet-2268	586	34	insulin	insulin	NOUN
admet-2268	586	35	.	.	PUNCT
admet-2268	587	1	international	international	ADJ
admet-2268	587	2	journal	journal	PROPN
admet-2268	587	3	of	of	ADP
admet-2268	587	4	nanomedicine	nanomedicine	PROPN
admet-2268	587	5	28	28	NUM
admet-2268	587	6	(	(	PUNCT
admet-2268	587	7	2011	2011	NUM
admet-2268	587	8	)	)	PUNCT
admet-2268	587	9	3049	3049	NUM
admet-2268	587	10	-	-	SYM
admet-2268	587	11	3056	3056	NUM
admet-2268	587	12	.	.	PUNCT
admet-2268	588	1	http://dx.doi.org/10.2147/ijn.s26450	http://dx.doi.org/10.2147/ijn.s26450	X
admet-2268	588	2	.	.	PUNCT
admet-2268	589	1	[	[	X
admet-2268	589	2	50	50	NUM
admet-2268	589	3	]	]	X
admet-2268	589	4	m.a	m.a	PROPN
admet-2268	589	5	.	.	PROPN
admet-2268	589	6	naseef	naseef	PROPN
admet-2268	589	7	,	,	PUNCT
admet-2268	589	8	h.k	h.k	PROPN
admet-2268	589	9	.	.	PROPN
admet-2268	589	10	ibrahim	ibrahim	PROPN
admet-2268	589	11	,	,	PUNCT
admet-2268	589	12	s.a.e	s.a.e	PROPN
admet-2268	589	13	.	.	PUNCT
admet-2268	590	1	nour	nour	PROPN
admet-2268	590	2	.	.	PUNCT
admet-2268	591	1	solid	solid	ADJ
admet-2268	591	2	form	form	NOUN
admet-2268	591	3	of	of	ADP
admet-2268	591	4	lipid	lipid	NOUN
admet-2268	591	5	-	-	PUNCT
admet-2268	591	6	based	base	VERB
admet-2268	591	7	self	self	NOUN
admet-2268	591	8	-	-	PUNCT
admet-2268	591	9	nanoemulsifying	nanoemulsifye	VERB
admet-2268	591	10	drug	drug	NOUN
admet-2268	591	11	delivery	delivery	NOUN
admet-2268	591	12	systems	system	NOUN
admet-2268	591	13	for	for	ADP
admet-2268	591	14	minimization	minimization	NOUN
admet-2268	591	15	of	of	ADP
admet-2268	591	16	diacerein	diacerein	ADJ
admet-2268	591	17	adverse	adverse	ADJ
admet-2268	591	18	effects	effect	NOUN
admet-2268	591	19	:	:	PUNCT
admet-2268	591	20	development	development	NOUN
admet-2268	591	21	and	and	CCONJ
admet-2268	591	22	bioequivalence	bioequivalence	NOUN
admet-2268	591	23	evaluation	evaluation	NOUN
admet-2268	591	24	in	in	ADP
admet-2268	591	25	albino	albino	NOUN
admet-2268	591	26	rabbits	rabbit	NOUN
admet-2268	591	27	.	.	PUNCT
admet-2268	592	1	aaps	aap	NOUN
admet-2268	592	2	pharmscitech	pharmscitech	VERB
admet-2268	592	3	19	19	NUM
admet-2268	592	4	(	(	PUNCT
admet-2268	592	5	2018	2018	NUM
admet-2268	592	6	)	)	PUNCT
admet-2268	592	7	3097	3097	NUM
admet-2268	592	8	-	-	SYM
admet-2268	592	9	3109	3109	NUM
admet-2268	592	10	.	.	PUNCT
admet-2268	593	1	https://doi.org/10.1208/s12249-018-1138-5	https://doi.org/10.1208/s12249-018-1138-5	NUM
admet-2268	593	2	.	.	PUNCT
admet-2268	594	1	[	[	X
admet-2268	594	2	51	51	NUM
admet-2268	594	3	]	]	PUNCT
admet-2268	594	4	l.	l.	PROPN
admet-2268	594	5	xiao	xiao	PROPN
admet-2268	594	6	,	,	PUNCT
admet-2268	594	7	a.j	a.j	PROPN
admet-2268	594	8	.	.	PROPN
admet-2268	594	9	poudel	poudel	PROPN
admet-2268	594	10	,	,	PUNCT
admet-2268	594	11	l.	l.	PROPN
admet-2268	594	12	huang	huang	PROPN
admet-2268	594	13	,	,	PUNCT
admet-2268	594	14	y.	y.	PROPN
admet-2268	594	15	wang	wang	PROPN
admet-2268	594	16	,	,	PUNCT
admet-2268	594	17	a.m.e	a.m.e	PROPN
admet-2268	594	18	.	.	PROPN
admet-2268	594	19	abdalla	abdalla	PROPN
admet-2268	594	20	,	,	PUNCT
admet-2268	594	21	g.	g.	PROPN
admet-2268	594	22	yang	yang	PROPN
admet-2268	594	23	.	.	PUNCT
admet-2268	595	1	nanocellulose	nanocellulose	PROPN
admet-2268	595	2	hyperfine	hyperfine	ADJ
admet-2268	595	3	network	network	NOUN
admet-2268	595	4	achieves	achieve	VERB
admet-2268	595	5	sustained	sustained	ADJ
admet-2268	595	6	release	release	NOUN
admet-2268	595	7	of	of	ADP
admet-2268	595	8	berberine	berberine	NOUN
admet-2268	595	9	hydrochloride	hydrochloride	NOUN
admet-2268	595	10	solubilized	solubilize	VERB
admet-2268	595	11	with	with	ADP
admet-2268	595	12	β	β	NOUN
admet-2268	595	13	-	-	NOUN
admet-2268	595	14	cyclodextrin	cyclodextrin	NOUN
admet-2268	595	15	for	for	ADP
admet-2268	595	16	potential	potential	ADJ
admet-2268	595	17	anti	anti	ADJ
admet-2268	595	18	-	-	ADJ
admet-2268	595	19	infection	infection	ADJ
admet-2268	595	20	oral	oral	ADJ
admet-2268	595	21	administration	administration	NOUN
admet-2268	595	22	.	.	PUNCT
admet-2268	596	1	international	international	ADJ
admet-2268	596	2	journal	journal	PROPN
admet-2268	596	3	of	of	ADP
admet-2268	596	4	biological	biological	ADJ
admet-2268	596	5	macromolecules	macromolecule	NOUN
admet-2268	596	6	153	153	NUM
admet-2268	596	7	(	(	PUNCT
admet-2268	596	8	2020	2020	NUM
admet-2268	596	9	)	)	PUNCT
admet-2268	596	10	633640	633640	NUM
admet-2268	596	11	.	.	PUNCT
admet-2268	597	1	https://doi.org/10.1016/j.ijbiomac.2020.03.030	https://doi.org/10.1016/j.ijbiomac.2020.03.030	X
admet-2268	597	2	.	.	PUNCT
admet-2268	598	1	[	[	X
admet-2268	598	2	52	52	NUM
admet-2268	598	3	]	]	PUNCT
admet-2268	598	4	x.	x.	PROPN
admet-2268	598	5	guan	guan	PROPN
admet-2268	598	6	,	,	PUNCT
admet-2268	598	7	l.	l.	PROPN
admet-2268	598	8	jiang	jiang	PROPN
admet-2268	598	9	,	,	PUNCT
admet-2268	598	10	l.	l.	PROPN
admet-2268	598	11	cai	cai	PROPN
admet-2268	598	12	,	,	PUNCT
admet-2268	598	13	l.	l.	PROPN
admet-2268	598	14	zhang	zhang	PROPN
admet-2268	598	15	,	,	PUNCT
admet-2268	598	16	x.	x.	PROPN
admet-2268	598	17	hu	hu	PROPN
admet-2268	598	18	.	.	PUNCT
admet-2268	599	1	a	a	DET
admet-2268	599	2	new	new	ADJ
admet-2268	599	3	co	co	NOUN
admet-2268	599	4	-	-	NOUN
admet-2268	599	5	crystal	crystal	NOUN
admet-2268	599	6	of	of	ADP
admet-2268	599	7	synthetic	synthetic	ADJ
admet-2268	599	8	drug	drug	NOUN
admet-2268	599	9	rosiglitazone	rosiglitazone	NOUN
admet-2268	599	10	with	with	ADP
admet-2268	599	11	natural	natural	ADJ
admet-2268	599	12	medicine	medicine	NOUN
admet-2268	599	13	berberine	berberine	NOUN
admet-2268	599	14	:	:	PUNCT
admet-2268	599	15	preparation	preparation	NOUN
admet-2268	599	16	,	,	PUNCT
admet-2268	599	17	crystal	crystal	NOUN
admet-2268	599	18	structures	structure	NOUN
admet-2268	599	19	,	,	PUNCT
admet-2268	599	20	and	and	CCONJ
admet-2268	599	21	dissolution	dissolution	NOUN
admet-2268	599	22	.	.	PUNCT
admet-2268	600	1	molecules	molecule	NOUN
admet-2268	600	2	25	25	NUM
admet-2268	600	3	(	(	PUNCT
admet-2268	600	4	2020	2020	NUM
admet-2268	600	5	)	)	PUNCT
admet-2268	600	6	4288	4288	NUM
admet-2268	600	7	.	.	PUNCT
admet-2268	601	1	https://doi.org/10.3390/molecules25184288	https://doi.org/10.3390/molecules25184288	NOUN
admet-2268	601	2	.	.	PUNCT
admet-2268	602	1	[	[	X
admet-2268	602	2	53	53	NUM
admet-2268	602	3	]	]	X
admet-2268	602	4	h.j	h.j	PROPN
admet-2268	602	5	.	.	PROPN
admet-2268	602	6	kim	kim	PROPN
admet-2268	602	7	,	,	PUNCT
admet-2268	602	8	s.h	s.h	PROPN
admet-2268	602	9	.	.	PROPN
admet-2268	602	10	kim	kim	PROPN
admet-2268	602	11	,	,	PUNCT
admet-2268	602	12	h.m	h.m	PROPN
admet-2268	602	13	.	.	PROPN
admet-2268	602	14	kim	kim	PROPN
admet-2268	602	15	,	,	PUNCT
admet-2268	602	16	y.s	y.s	PROPN
admet-2268	602	17	.	.	PROPN
admet-2268	602	18	kim	kim	PROPN
admet-2268	602	19	,	,	PUNCT
admet-2268	602	20	j.m	j.m	PROPN
admet-2268	602	21	.	.	PROPN
admet-2268	603	1	oh	oh	INTJ
admet-2268	603	2	.	.	PUNCT
admet-2268	604	1	surface	surface	NOUN
admet-2268	604	2	roughness	roughness	NOUN
admet-2268	604	3	effect	effect	NOUN
admet-2268	604	4	on	on	ADP
admet-2268	604	5	the	the	DET
admet-2268	604	6	cellular	cellular	ADJ
admet-2268	604	7	uptake	uptake	NOUN
admet-2268	604	8	of	of	ADP
admet-2268	604	9	layered	layered	ADJ
admet-2268	604	10	double	double	ADJ
admet-2268	604	11	hydroxide	hydroxide	NOUN
admet-2268	604	12	nanoparticles	nanoparticle	NOUN
admet-2268	604	13	.	.	PUNCT
admet-2268	605	1	applied	apply	VERB
admet-2268	605	2	clay	clay	NOUN
admet-2268	605	3	science	science	NOUN
admet-2268	605	4	202	202	NUM
admet-2268	605	5	(	(	PUNCT
admet-2268	605	6	2021	2021	NUM
admet-2268	605	7	)	)	PUNCT
admet-2268	605	8	105992	105992	NUM
admet-2268	605	9	.	.	PUNCT
admet-2268	606	1	https://doi.org/10.1016/j.clay.2021.105992	https://doi.org/10.1016/j.clay.2021.105992	ADJ
admet-2268	606	2	.	.	PUNCT
admet-2268	607	1	[	[	X
admet-2268	607	2	54	54	NUM
admet-2268	607	3	]	]	X
admet-2268	607	4	a.h	a.h	PROPN
admet-2268	607	5	.	.	PROPN
admet-2268	607	6	al	al	PROPN
admet-2268	607	7	shuwaili	shuwaili	PROPN
admet-2268	607	8	,	,	PUNCT
admet-2268	607	9	b.k	b.k	PROPN
admet-2268	607	10	.	.	PROPN
admet-2268	607	11	rasool	rasool	PROPN
admet-2268	607	12	,	,	PUNCT
admet-2268	607	13	a.a	a.a	PROPN
admet-2268	607	14	.	.	PROPN
admet-2268	607	15	abdulrasool	abdulrasool	PROPN
admet-2268	607	16	.	.	PUNCT
admet-2268	608	1	optimization	optimization	NOUN
admet-2268	608	2	of	of	ADP
admet-2268	608	3	elastic	elastic	ADJ
admet-2268	608	4	transfersomes	transfersome	NOUN
admet-2268	608	5	formulations	formulation	NOUN
admet-2268	608	6	for	for	ADP
admet-2268	608	7	transdermal	transdermal	ADJ
admet-2268	608	8	delivery	delivery	NOUN
admet-2268	608	9	of	of	ADP
admet-2268	608	10	pentoxifylline	pentoxifylline	NOUN
admet-2268	608	11	.	.	PUNCT
admet-2268	609	1	european	european	PROPN
admet-2268	609	2	journal	journal	PROPN
admet-2268	609	3	of	of	ADP
admet-2268	609	4	pharmaceutics	pharmaceutic	NOUN
admet-2268	609	5	and	and	CCONJ
admet-2268	609	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2268	609	7	102	102	NUM
admet-2268	609	8	(	(	PUNCT
admet-2268	609	9	2016	2016	NUM
admet-2268	609	10	)	)	PUNCT
admet-2268	609	11	101	101	NUM
admet-2268	609	12	-	-	SYM
admet-2268	609	13	114	114	NUM
admet-2268	609	14	.	.	PUNCT
admet-2268	610	1	https://doi.org/10.1016/j.ejpb.2016.02.013	https://doi.org/10.1016/j.ejpb.2016.02.013	PROPN
admet-2268	610	2	.	.	PUNCT
admet-2268	611	1	[	[	X
admet-2268	611	2	55	55	NUM
admet-2268	611	3	]	]	PUNCT
admet-2268	611	4	j.	j.	PROPN
admet-2268	611	5	pleńkowska	pleńkowska	PROPN
admet-2268	611	6	,	,	PUNCT
admet-2268	611	7	m.	m.	NOUN
admet-2268	611	8	gabig	gabig	NOUN
admet-2268	611	9	-	-	PUNCT
admet-2268	611	10	cimińska	cimińska	NOUN
admet-2268	611	11	,	,	PUNCT
admet-2268	611	12	p.	p.	PROPN
admet-2268	611	13	mozolewski	mozolewski	PROPN
admet-2268	611	14	.	.	PUNCT
admet-2268	612	1	oxidative	oxidative	ADJ
admet-2268	612	2	stress	stress	NOUN
admet-2268	612	3	as	as	ADP
admet-2268	612	4	an	an	DET
admet-2268	612	5	important	important	ADJ
admet-2268	612	6	contributor	contributor	NOUN
admet-2268	612	7	to	to	ADP
admet-2268	612	8	the	the	DET
admet-2268	612	9	pathogenesis	pathogenesis	NOUN
admet-2268	612	10	of	of	ADP
admet-2268	612	11	psoriasis	psoriasis	NOUN
admet-2268	612	12	.	.	PUNCT
admet-2268	613	1	international	international	ADJ
admet-2268	613	2	journal	journal	NOUN
admet-2268	613	3	of	of	ADP
admet-2268	613	4	molecular	molecular	ADJ
admet-2268	613	5	sciences	science	NOUN
admet-2268	613	6	21	21	NUM
admet-2268	613	7	(	(	PUNCT
admet-2268	613	8	2020	2020	NUM
admet-2268	613	9	)	)	PUNCT
admet-2268	613	10	6206	6206	NUM
admet-2268	613	11	.	.	PUNCT
admet-2268	614	1	https://doi.org/10.3390/ijms21176206	https://doi.org/10.3390/ijms21176206	PROPN
admet-2268	614	2	.	.	PUNCT
admet-2268	615	1	[	[	X
admet-2268	615	2	56	56	NUM
admet-2268	615	3	]	]	PUNCT
admet-2268	615	4	m.	m.	NOUN
admet-2268	615	5	wang	wang	PROPN
admet-2268	615	6	,	,	PUNCT
admet-2268	615	7	h.	h.	PROPN
admet-2268	615	8	xia	xia	PROPN
admet-2268	615	9	,	,	PUNCT
admet-2268	615	10	x.	x.	PROPN
admet-2268	615	11	yang	yang	PROPN
admet-2268	615	12	,	,	PUNCT
admet-2268	615	13	q.	q.	PROPN
admet-2268	615	14	zhang	zhang	PROPN
admet-2268	615	15	,	,	PUNCT
admet-2268	615	16	y.	y.	PROPN
admet-2268	615	17	li	li	PROPN
admet-2268	615	18	,	,	PUNCT
admet-2268	615	19	y.	y.	PROPN
admet-2268	615	20	wang	wang	PROPN
admet-2268	615	21	,	,	PUNCT
admet-2268	615	22	y.	y.	PROPN
admet-2268	615	23	xia	xia	PROPN
admet-2268	615	24	,	,	PUNCT
admet-2268	615	25	z.	z.	PROPN
admet-2268	615	26	xie	xie	PROPN
admet-2268	615	27	.	.	PUNCT
admet-2268	616	1	berberine	berberine	PROPN
admet-2268	616	2	hydrochloride	hydrochloride	NOUN
admet-2268	616	3	-	-	PUNCT
admet-2268	616	4	loaded	load	VERB
admet-2268	616	5	liposomes	liposome	NOUN
admet-2268	616	6	gel	gel	NOUN
admet-2268	616	7	:	:	PUNCT
admet-2268	616	8	preparation	preparation	NOUN
admet-2268	616	9	,	,	PUNCT
admet-2268	616	10	characterization	characterization	NOUN
admet-2268	616	11	and	and	CCONJ
admet-2268	616	12	antioxidant	antioxidant	ADJ
admet-2268	616	13	activity	activity	NOUN
admet-2268	616	14	.	.	PUNCT
admet-2268	617	1	indian	indian	ADJ
admet-2268	617	2	journal	journal	PROPN
admet-2268	617	3	of	of	ADP
admet-2268	617	4	pharmaceutical	pharmaceutical	ADJ
admet-2268	617	5	education	education	NOUN
admet-2268	617	6	and	and	CCONJ
admet-2268	617	7	research	research	NOUN
admet-2268	617	8	57	57	NUM
admet-2268	617	9	(	(	PUNCT
admet-2268	617	10	2023	2023	NUM
admet-2268	617	11	)	)	PUNCT
admet-2268	617	12	74	74	NUM
admet-2268	617	13	-	-	SYM
admet-2268	617	14	82	82	NUM
admet-2268	617	15	.	.	PUNCT
admet-2268	618	1	https://doi.org/10.5530/001954642087	https://doi.org/10.5530/001954642087	ADJ
admet-2268	618	2	.	.	PUNCT
admet-2268	619	1	[	[	X
admet-2268	619	2	57	57	NUM
admet-2268	619	3	]	]	X
admet-2268	619	4	r.n	r.n	PROPN
admet-2268	619	5	.	.	PROPN
admet-2268	619	6	abd	abd	PROPN
admet-2268	619	7	-	-	PROPN
admet-2268	619	8	ellatif	ellatif	PROPN
admet-2268	619	9	,	,	PUNCT
admet-2268	619	10	i.i	i.i	PROPN
admet-2268	619	11	.	.	PROPN
admet-2268	619	12	hegab	hegab	PROPN
admet-2268	619	13	,	,	PUNCT
admet-2268	619	14	m.m	m.m	PROPN
admet-2268	619	15	.	.	PROPN
admet-2268	619	16	atef	atef	PROPN
admet-2268	619	17	,	,	PUNCT
admet-2268	619	18	m.t	m.t	PROPN
admet-2268	619	19	.	.	PROPN
admet-2268	619	20	sadek	sadek	PROPN
admet-2268	619	21	,	,	PUNCT
admet-2268	619	22	y.m	y.m	PROPN
admet-2268	619	23	.	.	PROPN
admet-2268	619	24	hafez	hafez	PROPN
admet-2268	619	25	.	.	PUNCT
admet-2268	620	1	diacerein	diacerein	PROPN
admet-2268	620	2	protects	protect	VERB
admet-2268	620	3	against	against	ADP
admet-2268	620	4	glycerolinduced	glycerolinduced	ADJ
admet-2268	620	5	acute	acute	PROPN
admet-2268	620	6	kidney	kidney	NOUN
admet-2268	620	7	injury	injury	NOUN
admet-2268	620	8	:	:	PUNCT
admet-2268	620	9	modulating	modulate	VERB
admet-2268	620	10	oxidative	oxidative	ADJ
admet-2268	620	11	stress	stress	NOUN
admet-2268	620	12	,	,	PUNCT
admet-2268	620	13	inflammation	inflammation	NOUN
admet-2268	620	14	,	,	PUNCT
admet-2268	620	15	apoptosis	apoptosis	NOUN
admet-2268	620	16	and	and	CCONJ
admet-2268	620	17	necroptosis	necroptosis	NOUN
admet-2268	620	18	.	.	PUNCT
admet-2268	621	1	chemico	chemico	ADJ
admet-2268	621	2	-	-	ADJ
admet-2268	621	3	biological	biological	ADJ
admet-2268	621	4	interactions	interaction	NOUN
admet-2268	621	5	306	306	NUM
admet-2268	621	6	(	(	PUNCT
admet-2268	621	7	2019	2019	NUM
admet-2268	621	8	)	)	PUNCT
admet-2268	621	9	47	47	NUM
admet-2268	621	10	-	-	SYM
admet-2268	621	11	53	53	NUM
admet-2268	621	12	.	.	PUNCT
admet-2268	622	1	https://doi.org/10.1016/j.cbi.2019.04.008	https://doi.org/10.1016/j.cbi.2019.04.008	NOUN
admet-2268	622	2	.	.	PUNCT
admet-2268	623	1	[	[	X
admet-2268	623	2	58	58	NUM
admet-2268	623	3	]	]	SYM
admet-2268	623	4	i.f	i.f	PROPN
admet-2268	623	5	.	.	PROPN
admet-2268	623	6	chukwuma	chukwuma	PROPN
admet-2268	623	7	,	,	PUNCT
admet-2268	623	8	v.o	v.o	PROPN
admet-2268	623	9	.	.	PROPN
admet-2268	623	10	apeh	apeh	PROPN
admet-2268	623	11	,	,	PUNCT
admet-2268	623	12	f.n	f.n	PROPN
admet-2268	623	13	.	.	PROPN
admet-2268	623	14	nwora	nwora	PROPN
admet-2268	623	15	,	,	PUNCT
admet-2268	623	16	c.c	c.c	PROPN
admet-2268	623	17	.	.	PROPN
admet-2268	623	18	nkwocha	nkwocha	PROPN
admet-2268	623	19	,	,	PUNCT
admet-2268	623	20	s.e	s.e	PROPN
admet-2268	623	21	.	.	PROPN
admet-2268	623	22	mba	mba	PROPN
admet-2268	623	23	,	,	PUNCT
admet-2268	623	24	e.c	e.c	PROPN
admet-2268	623	25	.	.	PROPN
admet-2268	623	26	ossai	ossai	PROPN
admet-2268	623	27	.	.	PUNCT
admet-2268	624	1	phytochemical	phytochemical	ADJ
admet-2268	624	2	profiling	profiling	NOUN
admet-2268	624	3	and	and	CCONJ
admet-2268	624	4	antioxidative	antioxidative	ADJ
admet-2268	624	5	potential	potential	NOUN
admet-2268	624	6	of	of	ADP
admet-2268	624	7	phenolic	phenolic	ADJ
admet-2268	624	8	-	-	PUNCT
admet-2268	624	9	rich	rich	ADJ
admet-2268	624	10	extract	extract	NOUN
admet-2268	624	11	of	of	ADP
admet-2268	624	12	cola	cola	PROPN
admet-2268	624	13	acuminata	acuminata	PROPN
admet-2268	624	14	nuts	nut	NOUN
admet-2268	624	15	.	.	PUNCT
admet-2268	625	1	biointerface	biointerface	NOUN
admet-2268	625	2	research	research	NOUN
admet-2268	625	3	in	in	ADP
admet-2268	625	4	applied	apply	VERB
admet-2268	625	5	chemistry	chemistry	NOUN
admet-2268	625	6	13(1	13(1	NUM
admet-2268	625	7	)	)	PUNCT
admet-2268	625	8	(	(	PUNCT
admet-2268	625	9	2023	2023	NUM
admet-2268	625	10	)	)	PUNCT
admet-2268	625	11	29	29	NUM
admet-2268	625	12	.	.	PUNCT
admet-2268	626	1	https://doi.org/10.33263/briac131.029	https://doi.org/10.33263/briac131.029	NOUN
admet-2268	626	2	.	.	PUNCT
admet-2268	627	1	https://doi.org/10.5599/admet.2268	https://doi.org/10.5599/admet.2268	NOUN
admet-2268	627	2	https://doi.org/10.1208/s12249-016-0622-z	https://doi.org/10.1208/s12249-016-0622-z	PROPN
admet-2268	627	3	https://doi.org/10.1016/j.jrras.2023.100565	https://doi.org/10.1016/j.jrras.2023.100565	ADV
admet-2268	627	4	https://doi.org/10.31351/vol32isssuppl.pp244-253	https://doi.org/10.31351/vol32isssuppl.pp244-253	ADJ
admet-2268	627	5	https://doi.org/10.3390/pharmaceutics14091896	https://doi.org/10.3390/pharmaceutics14091896	PROPN
admet-2268	627	6	https://doi.org/10.1016/j.colsurfa.2019.124382	https://doi.org/10.1016/j.colsurfa.2019.124382	PROPN
admet-2268	627	7	http://dx.doi.org/10.2147/ijn.s26450	http://dx.doi.org/10.2147/ijn.s26450	PROPN
admet-2268	627	8	https://doi.org/10.1208/s12249-018-1138-5	https://doi.org/10.1208/s12249-018-1138-5	NUM
admet-2268	627	9	https://doi.org/10.1016/j.ijbiomac.2020.03.030	https://doi.org/10.1016/j.ijbiomac.2020.03.030	PROPN
admet-2268	627	10	https://doi.org/10.3390/molecules25184288	https://doi.org/10.3390/molecules25184288	PROPN
admet-2268	627	11	https://doi.org/10.1016/j.clay.2021.105992	https://doi.org/10.1016/j.clay.2021.105992	PROPN
admet-2268	627	12	https://doi.org/10.1016/j.ejpb.2016.02.013	https://doi.org/10.1016/j.ejpb.2016.02.013	PROPN
admet-2268	627	13	https://doi.org/10.3390/ijms21176206	https://doi.org/10.3390/ijms21176206	PROPN
admet-2268	627	14	https://doi.org/10.5530/001954642087	https://doi.org/10.5530/001954642087	NOUN
admet-2268	627	15	https://doi.org/10.1016/j.cbi.2019.04.008	https://doi.org/10.1016/j.cbi.2019.04.008	PROPN
admet-2268	627	16	https://doi.org/10.33263/briac131.029	https://doi.org/10.33263/briac131.029	VERB
admet-2268	627	17	s.	s.	PROPN
admet-2268	627	18	singh	singh	PROPN
admet-2268	627	19	and	and	CCONJ
admet-2268	627	20	r.	r.	PROPN
admet-2268	627	21	awasthi	awasthi	PROPN
admet-2268	627	22	admet	admet	PROPN
admet-2268	627	23	&	&	CCONJ
admet-2268	627	24	dmpk	dmpk	PROPN
admet-2268	627	25	12(3	12(3	PROPN
admet-2268	627	26	)	)	PUNCT
admet-2268	627	27	(	(	PUNCT
admet-2268	627	28	2024	2024	NUM
admet-2268	627	29	)	)	PUNCT
admet-2268	627	30	553	553	NUM
admet-2268	627	31	-	-	SYM
admet-2268	627	32	580	580	NUM
admet-2268	627	33	580	580	NUM
admet-2268	627	34	[	[	SYM
admet-2268	627	35	59	59	NUM
admet-2268	627	36	]	]	X
admet-2268	627	37	n.	n.	PROPN
admet-2268	627	38	ghavipanje	ghavipanje	PROPN
admet-2268	627	39	,	,	PUNCT
admet-2268	627	40	m.h	m.h	PROPN
admet-2268	627	41	.	.	PROPN
admet-2268	627	42	fathi	fathi	PROPN
admet-2268	627	43	nasri	nasri	PROPN
admet-2268	627	44	,	,	PUNCT
admet-2268	627	45	e.	e.	PROPN
admet-2268	627	46	vargas	vargas	PROPN
admet-2268	627	47	-	-	PUNCT
admet-2268	627	48	bello	bello	NOUN
admet-2268	627	49	-	-	PUNCT
admet-2268	627	50	pérez	pérez	NOUN
admet-2268	627	51	.	.	PUNCT
admet-2268	628	1	an	an	DET
admet-2268	628	2	insight	insight	NOUN
admet-2268	628	3	into	into	ADP
admet-2268	628	4	the	the	DET
admet-2268	628	5	potential	potential	NOUN
admet-2268	628	6	of	of	ADP
admet-2268	628	7	berberine	berberine	NOUN
admet-2268	628	8	in	in	ADP
admet-2268	628	9	animal	animal	NOUN
admet-2268	628	10	nutrition	nutrition	NOUN
admet-2268	628	11	:	:	PUNCT
admet-2268	628	12	current	current	ADJ
admet-2268	628	13	knowledge	knowledge	NOUN
admet-2268	628	14	and	and	CCONJ
admet-2268	628	15	future	future	ADJ
admet-2268	628	16	perspectives	perspective	NOUN
admet-2268	628	17	.	.	PUNCT
admet-2268	629	1	journal	journal	NOUN
admet-2268	629	2	of	of	ADP
admet-2268	629	3	animal	animal	NOUN
admet-2268	629	4	physiology	physiology	NOUN
admet-2268	629	5	and	and	CCONJ
admet-2268	629	6	animal	animal	NOUN
admet-2268	629	7	nutrition	nutrition	NOUN
admet-2268	629	8	(	(	PUNCT
admet-2268	629	9	berl	berl	PROPN
admet-2268	629	10	)	)	PUNCT
admet-2268	629	11	107	107	NUM
admet-2268	629	12	(	(	PUNCT
admet-2268	629	13	2023	2023	NUM
admet-2268	629	14	)	)	PUNCT
admet-2268	629	15	808	808	NUM
admet-2268	629	16	-	-	SYM
admet-2268	629	17	829	829	NUM
admet-2268	629	18	.	.	PUNCT
admet-2268	630	1	https://doi.org/10.1111/jpn.13769	https://doi.org/10.1111/jpn.13769	NOUN
admet-2268	630	2	.	.	PUNCT
admet-2268	631	1	[	[	X
admet-2268	631	2	60	60	NUM
admet-2268	631	3	]	]	PUNCT
admet-2268	631	4	environment	environment	NOUN
admet-2268	631	5	directorate	directorate	VERB
admet-2268	631	6	joint	joint	ADJ
admet-2268	631	7	meeting	meeting	NOUN
admet-2268	631	8	of	of	ADP
admet-2268	631	9	the	the	DET
admet-2268	631	10	chemicals	chemical	NOUN
admet-2268	631	11	committee	committee	NOUN
admet-2268	631	12	and	and	CCONJ
admet-2268	631	13	the	the	DET
admet-2268	631	14	working	work	VERB
admet-2268	631	15	party	party	NOUN
admet-2268	631	16	on	on	ADP
admet-2268	631	17	chemicals	chemical	NOUN
admet-2268	631	18	,	,	PUNCT
admet-2268	631	19	pesticides	pesticide	NOUN
admet-2268	631	20	and	and	CCONJ
admet-2268	631	21	biotechnology	biotechnology	NOUN
admet-2268	631	22	.	.	PUNCT
admet-2268	632	1	unclassified	unclassifie	VERB
admet-2268	632	2	.	.	PUNCT
admet-2268	633	1	env	env	PROPN
admet-2268	633	2	/	/	SYM
admet-2268	633	3	jm	jm	PROPN
admet-2268	633	4	/	/	SYM
admet-2268	633	5	mono(2011)36	mono(2011)36	PROPN
admet-2268	633	6	.	.	PUNCT
admet-2268	634	1	available	available	ADJ
admet-2268	634	2	from	from	ADP
admet-2268	634	3	:	:	PUNCT
admet-2268	634	4	https://www.oecd.org/env/ehs/organisationoftheenvironmenthealthandsafetyprogramme.htm	https://www.oecd.org/env/ehs/organisationoftheenvironmenthealthandsafetyprogramme.htm	PROPN
admet-2268	634	5	(	(	PUNCT
admet-2268	634	6	date	date	NOUN
admet-2268	634	7	accessed	access	VERB
admet-2268	634	8	:	:	PUNCT
admet-2268	634	9	19.03.2024	19.03.2024	NUM
admet-2268	634	10	)	)	PUNCT
admet-2268	634	11	.	.	PUNCT
admet-2268	635	1	[	[	X
admet-2268	635	2	61	61	NUM
admet-2268	635	3	]	]	X
admet-2268	635	4	a.j	a.j	PROPN
admet-2268	635	5	.	.	PROPN
admet-2268	635	6	guillot	guillot	PROPN
admet-2268	635	7	,	,	PUNCT
admet-2268	635	8	m.	m.	NOUN
admet-2268	635	9	martínez	martínez	PROPN
admet-2268	635	10	-	-	PUNCT
admet-2268	635	11	navarrete	navarrete	PROPN
admet-2268	635	12	,	,	PUNCT
admet-2268	635	13	t.m	t.m	PROPN
admet-2268	635	14	.	.	PROPN
admet-2268	635	15	garrigues	garrigues	PROPN
admet-2268	635	16	,	,	PUNCT
admet-2268	635	17	a.	a.	NOUN
admet-2268	635	18	melero	melero	PROPN
admet-2268	635	19	.	.	PUNCT
admet-2268	636	1	skin	skin	NOUN
admet-2268	636	2	drug	drug	NOUN
admet-2268	636	3	delivery	delivery	NOUN
admet-2268	636	4	using	use	VERB
admet-2268	636	5	lipid	lipid	ADJ
admet-2268	636	6	vesicles	vesicle	NOUN
admet-2268	636	7	:	:	PUNCT
admet-2268	636	8	a	a	DET
admet-2268	636	9	starting	starting	NOUN
admet-2268	636	10	guideline	guideline	NOUN
admet-2268	636	11	for	for	ADP
admet-2268	636	12	their	their	PRON
admet-2268	636	13	development	development	NOUN
admet-2268	636	14	.	.	PUNCT
admet-2268	637	1	journal	journal	PROPN
admet-2268	637	2	of	of	ADP
admet-2268	637	3	controlled	control	VERB
admet-2268	637	4	release	release	NOUN
admet-2268	637	5	355	355	NUM
admet-2268	637	6	(	(	PUNCT
admet-2268	637	7	2023	2023	NUM
admet-2268	637	8	)	)	PUNCT
admet-2268	637	9	624	624	NUM
admet-2268	637	10	-	-	SYM
admet-2268	637	11	654	654	NUM
admet-2268	637	12	.	.	PUNCT
admet-2268	638	1	https://doi.org/10.1016/j.jconrel.2023.02.006	https://doi.org/10.1016/j.jconrel.2023.02.006	PROPN
admet-2268	638	2	.	.	PUNCT
admet-2268	639	1	[	[	X
admet-2268	639	2	62	62	NUM
admet-2268	639	3	]	]	PUNCT
admet-2268	639	4	a.	a.	NOUN
admet-2268	639	5	zeb	zeb	PROPN
admet-2268	639	6	,	,	PUNCT
admet-2268	639	7	o.s	o.s	PROPN
admet-2268	639	8	.	.	PROPN
admet-2268	639	9	qureshi	qureshi	PROPN
admet-2268	639	10	,	,	PUNCT
admet-2268	639	11	h.s	h.s	PROPN
admet-2268	639	12	.	.	PROPN
admet-2268	639	13	kim	kim	PROPN
admet-2268	639	14	,	,	PUNCT
admet-2268	639	15	j.h	j.h	PROPN
admet-2268	639	16	.	.	PROPN
admet-2268	639	17	cha	cha	PROPN
admet-2268	639	18	,	,	PUNCT
admet-2268	639	19	h.s	h.s	PROPN
admet-2268	639	20	.	.	PROPN
admet-2268	639	21	kim	kim	PROPN
admet-2268	639	22	,	,	PUNCT
admet-2268	639	23	j.k	j.k	PROPN
admet-2268	639	24	.	.	PUNCT
admet-2268	639	25	kim	kim	PROPN
admet-2268	639	26	.	.	PROPN
admet-2268	639	27	improved	improve	VERB
admet-2268	639	28	skin	skin	NOUN
admet-2268	639	29	permeation	permeation	NOUN
admet-2268	639	30	of	of	ADP
admet-2268	639	31	methotrexate	methotrexate	NOUN
admet-2268	639	32	via	via	ADP
admet-2268	639	33	nanosized	nanosized	ADJ
admet-2268	639	34	ultradeformable	ultradeformable	ADJ
admet-2268	639	35	liposomes	liposome	NOUN
admet-2268	639	36	.	.	PUNCT
admet-2268	640	1	internation	internation	NOUN
admet-2268	640	2	journal	journal	PROPN
admet-2268	640	3	of	of	ADP
admet-2268	640	4	nanomedicine	nanomedicine	ADJ
admet-2268	640	5	11	11	NUM
admet-2268	640	6	(	(	PUNCT
admet-2268	640	7	2016	2016	NUM
admet-2268	640	8	)	)	PUNCT
admet-2268	640	9	3813	3813	NUM
admet-2268	640	10	-	-	SYM
admet-2268	640	11	3824	3824	NUM
admet-2268	640	12	.	.	PUNCT
admet-2268	641	1	https://doi.org/10.2147/ijn.s109565	https://doi.org/10.2147/ijn.s109565	NOUN
admet-2268	641	2	.	.	PUNCT
admet-2268	642	1	©	©	ADP
admet-2268	642	2	2024	2024	NUM
admet-2268	642	3	by	by	ADP
admet-2268	642	4	the	the	DET
admet-2268	642	5	authors	author	NOUN
admet-2268	642	6	;	;	PUNCT
admet-2268	642	7	licensee	licensee	PROPN
admet-2268	642	8	iapc	iapc	PROPN
admet-2268	642	9	,	,	PUNCT
admet-2268	642	10	zagreb	zagreb	PROPN
admet-2268	642	11	,	,	PUNCT
admet-2268	642	12	croatia	croatia	PROPN
admet-2268	642	13	.	.	PUNCT
admet-2268	643	1	this	this	DET
admet-2268	643	2	article	article	NOUN
admet-2268	643	3	is	be	AUX
admet-2268	643	4	an	an	DET
admet-2268	643	5	open	open	ADJ
admet-2268	643	6	-	-	PUNCT
admet-2268	643	7	access	access	NOUN
admet-2268	643	8	article	article	NOUN
admet-2268	643	9	distributed	distribute	VERB
admet-2268	643	10	under	under	ADP
admet-2268	643	11	the	the	DET
admet-2268	643	12	terms	term	NOUN
admet-2268	643	13	and	and	CCONJ
admet-2268	643	14	conditions	condition	NOUN
admet-2268	643	15	of	of	ADP
admet-2268	643	16	the	the	DET
admet-2268	643	17	creative	creative	ADJ
admet-2268	643	18	commons	common	NOUN
admet-2268	643	19	attribution	attribution	NOUN
admet-2268	643	20	license	license	NOUN
admet-2268	643	21	(	(	PUNCT
admet-2268	643	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2268	643	23	)	)	PUNCT
admet-2268	643	24	https://doi.org/10.1111/jpn.13769	https://doi.org/10.1111/jpn.13769	PROPN
admet-2268	643	25	https://www.oecd.org/env/ehs/organisationoftheenvironmenthealthandsafetyprogramme.htm	https://www.oecd.org/env/ehs/organisationoftheenvironmenthealthandsafetyprogramme.htm	PROPN
admet-2268	644	1	https://doi.org/10.1016/j.jconrel.2023.02.006	https://doi.org/10.1016/j.jconrel.2023.02.006	PROPN
admet-2268	644	2	https://doi.org/10.2147/ijn.s109565	https://doi.org/10.2147/ijn.s109565	ADV
admet-2268	644	3	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN