id	sid	tid	token	lemma	pos
admet-2334	1	1	molecular	molecular	ADJ
admet-2334	1	2	properties	property	NOUN
admet-2334	1	3	,	,	PUNCT
admet-2334	1	4	including	include	VERB
admet-2334	1	5	chameleonicity	chameleonicity	NOUN
admet-2334	1	6	,	,	PUNCT
admet-2334	1	7	as	as	ADP
admet-2334	1	8	essential	essential	ADJ
admet-2334	1	9	tools	tool	NOUN
admet-2334	1	10	for	for	ADP
admet-2334	1	11	designing	design	VERB
admet-2334	1	12	the	the	DET
admet-2334	1	13	next	next	ADJ
admet-2334	1	14	generation	generation	NOUN
admet-2334	1	15	of	of	ADP
admet-2334	1	16	oral	oral	ADJ
admet-2334	1	17	beyond	beyond	ADP
admet-2334	1	18	rule	rule	NOUN
admet-2334	1	19	of	of	ADP
admet-2334	1	20	five	five	NUM
admet-2334	1	21	drugs	drug	NOUN
admet-2334	1	22	doi	doi	NOUN
admet-2334	1	23	:	:	PUNCT
admet-2334	1	24	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	NOUN
admet-2334	1	25	721	721	NUM
admet-2334	1	26	admet	admet	X
admet-2334	1	27	&	&	CCONJ
admet-2334	1	28	dmpk	dmpk	PROPN
admet-2334	1	29	12(5	12(5	NUM
admet-2334	1	30	)	)	PUNCT
admet-2334	1	31	(	(	PUNCT
admet-2334	1	32	2024	2024	NUM
admet-2334	1	33	)	)	PUNCT
admet-2334	1	34	721	721	NUM
admet-2334	1	35	-	-	NUM
admet-2334	1	36	736	736	NUM
admet-2334	1	37	;	;	PUNCT
admet-2334	1	38	doi	doi	NOUN
admet-2334	1	39	:	:	PUNCT
admet-2334	1	40	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	1	41	open	open	ADJ
admet-2334	1	42	access	access	NOUN
admet-2334	1	43	:	:	PUNCT
admet-2334	1	44	issn	issn	PROPN
admet-2334	1	45	:	:	PUNCT
admet-2334	1	46	1848	1848	NUM
admet-2334	1	47	-	-	SYM
admet-2334	1	48	7718	7718	NUM
admet-2334	1	49	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2334	1	50	original	original	ADJ
admet-2334	1	51	scientific	scientific	ADJ
admet-2334	1	52	paper	paper	NOUN
admet-2334	1	53	molecular	molecular	ADJ
admet-2334	1	54	properties	property	NOUN
admet-2334	1	55	,	,	PUNCT
admet-2334	1	56	including	include	VERB
admet-2334	1	57	chameleonicity	chameleonicity	NOUN
admet-2334	1	58	,	,	PUNCT
admet-2334	1	59	as	as	ADP
admet-2334	1	60	essential	essential	ADJ
admet-2334	1	61	tools	tool	NOUN
admet-2334	1	62	for	for	ADP
admet-2334	1	63	designing	design	VERB
admet-2334	1	64	the	the	DET
admet-2334	1	65	next	next	ADJ
admet-2334	1	66	generation	generation	NOUN
admet-2334	1	67	of	of	ADP
admet-2334	1	68	oral	oral	ADJ
admet-2334	1	69	beyond	beyond	ADP
admet-2334	1	70	rule	rule	NOUN
admet-2334	1	71	of	of	ADP
admet-2334	1	72	five	five	NUM
admet-2334	1	73	drugs	drug	NOUN
admet-2334	1	74	diego	diego	PROPN
admet-2334	1	75	garcía	garcía	PROPN
admet-2334	1	76	jiménez	jiménez	PROPN
admet-2334	1	77	,	,	PUNCT
admet-2334	1	78	maura	maura	PROPN
admet-2334	1	79	vallaro	vallaro	PROPN
admet-2334	1	80	,	,	PUNCT
admet-2334	1	81	luigi	luigi	PROPN
admet-2334	1	82	vitagliano	vitagliano	PROPN
admet-2334	1	83	,	,	PUNCT
admet-2334	1	84	lucía	lucía	ADJ
admet-2334	1	85	lópez	lópez	NOUN
admet-2334	1	86	lópez	lópez	NOUN
admet-2334	1	87	,	,	PUNCT
admet-2334	1	88	giulia	giulia	PROPN
admet-2334	1	89	apprato	apprato	PROPN
admet-2334	1	90	,	,	PUNCT
admet-2334	1	91	giuseppe	giuseppe	PROPN
admet-2334	1	92	ermondi	ermondi	PROPN
admet-2334	1	93	,	,	PUNCT
admet-2334	1	94	giulia	giulia	PROPN
admet-2334	1	95	caron	caron	PROPN
admet-2334	1	96	*	*	PROPN
admet-2334	1	97	cassmedchem	cassmedchem	PROPN
admet-2334	1	98	,	,	PUNCT
admet-2334	1	99	molecular	molecular	ADJ
admet-2334	1	100	biotechnology	biotechnology	NOUN
admet-2334	1	101	and	and	CCONJ
admet-2334	1	102	health	health	NOUN
admet-2334	1	103	sciences	sciences	PROPN
admet-2334	1	104	dept	dept	PROPN
admet-2334	1	105	.	.	PROPN
admet-2334	1	106	,	,	PUNCT
admet-2334	1	107	university	university	PROPN
admet-2334	1	108	of	of	ADP
admet-2334	1	109	torino	torino	NOUN
admet-2334	1	110	,	,	PUNCT
admet-2334	1	111	piazza	piazza	PROPN
admet-2334	1	112	nizza	nizza	PROPN
admet-2334	1	113	44	44	NUM
admet-2334	1	114	,	,	PUNCT
admet-2334	1	115	10126	10126	NUM
admet-2334	1	116	torino	torino	NOUN
admet-2334	1	117	,	,	PUNCT
admet-2334	1	118	italy	italy	PROPN
admet-2334	1	119	*	*	PUNCT
admet-2334	1	120	corresponding	correspond	VERB
admet-2334	1	121	author	author	NOUN
admet-2334	1	122	:	:	PUNCT
admet-2334	1	123	e	e	NOUN
admet-2334	1	124	-	-	NOUN
admet-2334	1	125	mail	mail	NOUN
admet-2334	1	126	:	:	PUNCT
admet-2334	1	127	giulia.caron@unito.it	giulia.caron@unito.it	NOUN
admet-2334	1	128	;	;	PUNCT
admet-2334	1	129	tel	tel	PROPN
admet-2334	1	130	.	.	PUNCT
admet-2334	1	131	:	:	PUNCT
admet-2334	2	1	+39	+39	PROPN
admet-2334	2	2	0116706371	0116706371	NUM
admet-2334	2	3	received	receive	VERB
admet-2334	2	4	:	:	PUNCT
admet-2334	2	5	march	march	PROPN
admet-2334	2	6	22	22	NUM
admet-2334	2	7	,	,	PUNCT
admet-2334	2	8	2024	2024	NUM
admet-2334	2	9	;	;	PUNCT
admet-2334	2	10	revised	revise	VERB
admet-2334	2	11	:	:	PUNCT
admet-2334	2	12	july	july	PROPN
admet-2334	2	13	31	31	NUM
admet-2334	2	14	,	,	PUNCT
admet-2334	2	15	2024	2024	NUM
admet-2334	2	16	;	;	PUNCT
admet-2334	2	17	published	publish	VERB
admet-2334	2	18	:	:	PUNCT
admet-2334	2	19	august	august	PROPN
admet-2334	2	20	27	27	NUM
admet-2334	2	21	,	,	PUNCT
admet-2334	2	22	2024	2024	NUM
admet-2334	2	23	abstract	abstract	ADJ
admet-2334	2	24	background	background	NOUN
admet-2334	2	25	and	and	CCONJ
admet-2334	2	26	purpose	purpose	NOUN
admet-2334	2	27	:	:	PUNCT
admet-2334	2	28	the	the	DET
admet-2334	2	29	classical	classical	ADJ
admet-2334	2	30	drug	drug	NOUN
admet-2334	2	31	discovery	discovery	NOUN
admet-2334	2	32	toolbox	toolbox	NOUN
admet-2334	2	33	continually	continually	ADV
admet-2334	2	34	expands	expand	VERB
admet-2334	2	35	beyond	beyond	ADP
admet-2334	2	36	traditional	traditional	ADJ
admet-2334	2	37	rule	rule	NOUN
admet-2334	2	38	of	of	ADP
admet-2334	2	39	five	five	NUM
admet-2334	2	40	(	(	PUNCT
admet-2334	2	41	ro5)-compliant	ro5)-compliant	ADJ
admet-2334	2	42	small	small	ADJ
admet-2334	2	43	molecules	molecule	NOUN
admet-2334	2	44	to	to	PART
admet-2334	2	45	include	include	VERB
admet-2334	2	46	new	new	ADJ
admet-2334	2	47	chemical	chemical	NOUN
admet-2334	2	48	modalities	modality	NOUN
admet-2334	2	49	for	for	ADP
admet-2334	2	50	difficult	difficult	ADJ
admet-2334	2	51	-	-	PUNCT
admet-2334	2	52	to	to	ADP
admet-2334	2	53	-	-	PUNCT
admet-2334	2	54	drug	drug	NOUN
admet-2334	2	55	targets	target	NOUN
admet-2334	2	56	.	.	PUNCT
admet-2334	3	1	the	the	DET
admet-2334	3	2	paper	paper	NOUN
admet-2334	3	3	focuses	focus	VERB
admet-2334	3	4	on	on	ADP
admet-2334	3	5	the	the	DET
admet-2334	3	6	molecular	molecular	ADJ
admet-2334	3	7	properties	property	NOUN
admet-2334	3	8	essential	essential	ADJ
admet-2334	3	9	to	to	PART
admet-2334	3	10	drive	drive	VERB
admet-2334	3	11	oral	oral	ADJ
admet-2334	3	12	bioavailability	bioavailability	NOUN
admet-2334	3	13	within	within	ADP
admet-2334	3	14	the	the	DET
admet-2334	3	15	bro5	bro5	NOUN
admet-2334	3	16	framework	framework	NOUN
admet-2334	3	17	.	.	PUNCT
admet-2334	4	1	experimental	experimental	ADJ
admet-2334	4	2	approach	approach	NOUN
admet-2334	4	3	:	:	PUNCT
admet-2334	4	4	the	the	DET
admet-2334	4	5	first	first	ADJ
admet-2334	4	6	part	part	NOUN
admet-2334	4	7	outlines	outline	VERB
admet-2334	4	8	the	the	DET
admet-2334	4	9	concept	concept	NOUN
admet-2334	4	10	and	and	CCONJ
admet-2334	4	11	methodologies	methodology	NOUN
admet-2334	4	12	for	for	ADP
admet-2334	4	13	characterizing	characterize	VERB
admet-2334	4	14	bro5	bro5	NOUN
admet-2334	4	15	physicochemical	physicochemical	ADJ
admet-2334	4	16	properties	property	NOUN
admet-2334	4	17	,	,	PUNCT
admet-2334	4	18	including	include	VERB
admet-2334	4	19	considerations	consideration	NOUN
admet-2334	4	20	on	on	ADP
admet-2334	4	21	chameleonicity	chameleonicity	NOUN
admet-2334	4	22	;	;	PUNCT
admet-2334	4	23	in	in	ADP
admet-2334	4	24	particular	particular	ADJ
admet-2334	4	25	,	,	PUNCT
admet-2334	4	26	the	the	DET
admet-2334	4	27	paper	paper	NOUN
admet-2334	4	28	summarizes	summarize	VERB
admet-2334	4	29	the	the	DET
admet-2334	4	30	content	content	NOUN
admet-2334	4	31	of	of	ADP
admet-2334	4	32	the	the	DET
admet-2334	4	33	last	last	ADJ
admet-2334	4	34	author	author	NOUN
admet-2334	4	35	’s	’s	PART
admet-2334	4	36	talk	talk	NOUN
admet-2334	4	37	presented	present	VERB
admet-2334	4	38	during	during	ADP
admet-2334	4	39	the	the	DET
admet-2334	4	40	iapc-10	iapc-10	PROPN
admet-2334	4	41	meeting	meeting	NOUN
admet-2334	4	42	held	hold	VERB
admet-2334	4	43	in	in	ADP
admet-2334	4	44	belgrade	belgrade	PROPN
admet-2334	4	45	in	in	ADP
admet-2334	4	46	september	september	PROPN
admet-2334	4	47	2023	2023	NUM
admet-2334	4	48	(	(	PUNCT
admet-2334	4	49	https://iapchem.org/index.php/iapc-10-home	https://iapchem.org/index.php/iapc-10-home	PROPN
admet-2334	4	50	)	)	PUNCT
admet-2334	4	51	.	.	PUNCT
admet-2334	5	1	the	the	DET
admet-2334	5	2	second	second	ADJ
admet-2334	5	3	part	part	NOUN
admet-2334	5	4	of	of	ADP
admet-2334	5	5	the	the	DET
admet-2334	5	6	manuscript	manuscript	NOUN
admet-2334	5	7	presents	present	VERB
admet-2334	5	8	novel	novel	ADJ
admet-2334	5	9	experimental	experimental	ADJ
admet-2334	5	10	and	and	CCONJ
admet-2334	5	11	computational	computational	ADJ
admet-2334	5	12	data	datum	NOUN
admet-2334	5	13	on	on	ADP
admet-2334	5	14	three	three	NUM
admet-2334	5	15	proteolysis	proteolysis	NOUN
admet-2334	5	16	targeting	target	VERB
admet-2334	5	17	chimeras	chimera	NOUN
admet-2334	5	18	(	(	PUNCT
admet-2334	5	19	protacs	protac	NOUN
admet-2334	5	20	)	)	PUNCT
admet-2334	5	21	currently	currently	ADV
admet-2334	5	22	in	in	ADP
admet-2334	5	23	clinical	clinical	ADJ
admet-2334	5	24	trials	trial	NOUN
admet-2334	5	25	.	.	PUNCT
admet-2334	6	1	key	key	ADJ
admet-2334	6	2	results	result	NOUN
admet-2334	6	3	:	:	PUNCT
admet-2334	6	4	molecular	molecular	ADJ
admet-2334	6	5	descriptors	descriptor	NOUN
admet-2334	6	6	of	of	ADP
admet-2334	6	7	arv-110	arv-110	PROPN
admet-2334	6	8	,	,	PUNCT
admet-2334	6	9	arv-471	arv-471	NOUN
admet-2334	6	10	,	,	PUNCT
admet-2334	6	11	and	and	CCONJ
admet-2334	6	12	dt-2216	dt-2216	PROPN
admet-2334	6	13	are	be	AUX
admet-2334	6	14	reported	report	VERB
admet-2334	6	15	and	and	CCONJ
admet-2334	6	16	the	the	DET
admet-2334	6	17	main	main	ADJ
admet-2334	6	18	limitations	limitation	NOUN
admet-2334	6	19	of	of	ADP
admet-2334	6	20	the	the	DET
admet-2334	6	21	applied	apply	VERB
admet-2334	6	22	experimental	experimental	ADJ
admet-2334	6	23	approaches	approach	NOUN
admet-2334	6	24	are	be	AUX
admet-2334	6	25	discussed	discuss	VERB
admet-2334	6	26	.	.	PUNCT
admet-2334	7	1	moreover	moreover	ADV
admet-2334	7	2	,	,	PUNCT
admet-2334	7	3	a	a	DET
admet-2334	7	4	simple	simple	ADJ
admet-2334	7	5	computational	computational	ADJ
admet-2334	7	6	method	method	NOUN
admet-2334	7	7	shows	show	VERB
admet-2334	7	8	how	how	SCONJ
admet-2334	7	9	predicting	predict	VERB
admet-2334	7	10	the	the	DET
admet-2334	7	11	presence	presence	NOUN
admet-2334	7	12	of	of	ADP
admet-2334	7	13	chameleonic	chameleonic	ADJ
admet-2334	7	14	effects	effect	NOUN
admet-2334	7	15	.	.	PUNCT
admet-2334	8	1	conclusion	conclusion	NOUN
admet-2334	8	2	:	:	PUNCT
admet-2334	8	3	a	a	DET
admet-2334	8	4	full	full	ADJ
admet-2334	8	5	complete	complete	ADJ
admet-2334	8	6	physicochemical	physicochemical	ADJ
admet-2334	8	7	characterization	characterization	NOUN
admet-2334	8	8	of	of	ADP
admet-2334	8	9	three	three	NUM
admet-2334	8	10	degraders	degrader	NOUN
admet-2334	8	11	in	in	ADP
admet-2334	8	12	clinical	clinical	ADJ
admet-2334	8	13	trials	trial	NOUN
admet-2334	8	14	is	be	AUX
admet-2334	8	15	reported	report	VERB
admet-2334	8	16	to	to	PART
admet-2334	8	17	highlight	highlight	VERB
admet-2334	8	18	the	the	DET
admet-2334	8	19	differences	difference	NOUN
admet-2334	8	20	in	in	ADP
admet-2334	8	21	physicochemical	physicochemical	ADJ
admet-2334	8	22	descriptors	descriptor	NOUN
admet-2334	8	23	between	between	ADP
admet-2334	8	24	protacs	protac	NOUN
admet-2334	8	25	dosed	dose	VERB
admet-2334	8	26	orally	orally	ADV
admet-2334	8	27	and	and	CCONJ
admet-2334	8	28	intravenously	intravenously	ADV
admet-2334	8	29	.	.	PUNCT
admet-2334	9	1	©	©	ADP
admet-2334	9	2	2024	2024	NUM
admet-2334	9	3	by	by	ADP
admet-2334	9	4	the	the	DET
admet-2334	9	5	authors	author	NOUN
admet-2334	9	6	.	.	PUNCT
admet-2334	10	1	this	this	DET
admet-2334	10	2	article	article	NOUN
admet-2334	10	3	is	be	AUX
admet-2334	10	4	an	an	DET
admet-2334	10	5	open	open	ADJ
admet-2334	10	6	-	-	PUNCT
admet-2334	10	7	access	access	NOUN
admet-2334	10	8	article	article	NOUN
admet-2334	10	9	distributed	distribute	VERB
admet-2334	10	10	under	under	ADP
admet-2334	10	11	the	the	DET
admet-2334	10	12	terms	term	NOUN
admet-2334	10	13	and	and	CCONJ
admet-2334	10	14	conditions	condition	NOUN
admet-2334	10	15	of	of	ADP
admet-2334	10	16	the	the	DET
admet-2334	10	17	creative	creative	ADJ
admet-2334	10	18	commons	common	NOUN
admet-2334	10	19	attribution	attribution	NOUN
admet-2334	10	20	license	license	NOUN
admet-2334	10	21	(	(	PUNCT
admet-2334	10	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2334	10	23	)	)	PUNCT
admet-2334	10	24	.	.	PUNCT
admet-2334	11	1	keywords	keyword	VERB
admet-2334	11	2	bro5	bro5	NOUN
admet-2334	11	3	;	;	PUNCT
admet-2334	11	4	chameleonicity	chameleonicity	NOUN
admet-2334	11	5	;	;	PUNCT
admet-2334	11	6	ionization	ionization	NOUN
admet-2334	11	7	;	;	PUNCT
admet-2334	11	8	lipophilicity	lipophilicity	NOUN
admet-2334	11	9	;	;	PUNCT
admet-2334	11	10	new	new	ADJ
admet-2334	11	11	chemical	chemical	NOUN
admet-2334	11	12	modalities	modality	NOUN
admet-2334	11	13	,	,	PUNCT
admet-2334	11	14	polarity	polarity	NOUN
admet-2334	11	15	,	,	PUNCT
admet-2334	11	16	protacs	protacs	PROPN
admet-2334	11	17	.	.	PUNCT
admet-2334	12	1	new	new	ADJ
admet-2334	12	2	chemical	chemical	NOUN
admet-2334	12	3	modalities	modality	NOUN
admet-2334	12	4	:	:	PUNCT
admet-2334	12	5	beyond	beyond	ADP
admet-2334	12	6	traditional	traditional	ADJ
admet-2334	12	7	rule	rule	NOUN
admet-2334	12	8	of	of	ADP
admet-2334	12	9	five	five	NUM
admet-2334	12	10	and	and	CCONJ
admet-2334	12	11	their	their	PRON
admet-2334	12	12	peculiar	peculiar	ADJ
admet-2334	12	13	properties	property	NOUN
admet-2334	12	14	as	as	SCONJ
admet-2334	12	15	the	the	DET
admet-2334	12	16	new	new	ADJ
admet-2334	12	17	millennium	millennium	NOUN
admet-2334	12	18	approached	approach	VERB
admet-2334	12	19	,	,	PUNCT
admet-2334	12	20	breakthroughs	breakthrough	NOUN
admet-2334	12	21	in	in	ADP
admet-2334	12	22	genomics	genomic	NOUN
admet-2334	12	23	and	and	CCONJ
admet-2334	12	24	human	human	ADJ
admet-2334	12	25	biology	biology	NOUN
admet-2334	12	26	unveiled	unveil	VERB
admet-2334	12	27	a	a	DET
admet-2334	12	28	plethora	plethora	NOUN
admet-2334	12	29	of	of	ADP
admet-2334	12	30	potential	potential	ADJ
admet-2334	12	31	drug	drug	NOUN
admet-2334	12	32	targets	target	NOUN
admet-2334	12	33	,	,	PUNCT
admet-2334	12	34	including	include	VERB
admet-2334	12	35	genes	gene	NOUN
admet-2334	12	36	and	and	CCONJ
admet-2334	12	37	proteins	protein	NOUN
admet-2334	12	38	that	that	PRON
admet-2334	12	39	were	be	AUX
admet-2334	12	40	previously	previously	ADV
admet-2334	12	41	unknown	unknown	ADJ
admet-2334	12	42	or	or	CCONJ
admet-2334	12	43	deemed	deem	VERB
admet-2334	12	44	"	"	PUNCT
admet-2334	12	45	undruggable	undruggable	ADJ
admet-2334	12	46	"	"	PUNCT
admet-2334	12	47	using	use	VERB
admet-2334	12	48	conventional	conventional	ADJ
admet-2334	12	49	methods	method	NOUN
admet-2334	12	50	[	[	X
admet-2334	12	51	1	1	NUM
admet-2334	12	52	]	]	PUNCT
admet-2334	12	53	.	.	PUNCT
admet-2334	13	1	this	this	PRON
admet-2334	13	2	offered	offer	VERB
admet-2334	13	3	an	an	DET
admet-2334	13	4	opportunity	opportunity	NOUN
admet-2334	13	5	to	to	PART
admet-2334	13	6	propel	propel	VERB
admet-2334	13	7	small	small	ADJ
admet-2334	13	8	molecule	molecule	NOUN
admet-2334	13	9	drug	drug	NOUN
admet-2334	13	10	discovery	discovery	NOUN
admet-2334	13	11	forward	forward	ADV
admet-2334	13	12	,	,	PUNCT
admet-2334	13	13	breaking	break	VERB
admet-2334	13	14	free	free	ADJ
admet-2334	13	15	from	from	ADP
admet-2334	13	16	traditional	traditional	ADJ
admet-2334	13	17	targets	target	NOUN
admet-2334	13	18	.	.	PUNCT
admet-2334	14	1	additionally	additionally	ADV
admet-2334	14	2	,	,	PUNCT
admet-2334	14	3	it	it	PRON
admet-2334	14	4	fostered	foster	VERB
admet-2334	14	5	the	the	DET
admet-2334	14	6	development	development	NOUN
admet-2334	14	7	of	of	ADP
admet-2334	14	8	novel	novel	ADJ
admet-2334	14	9	chemical	chemical	NOUN
admet-2334	14	10	modalities	modality	NOUN
admet-2334	14	11	(	(	PUNCT
admet-2334	14	12	ncms	ncms	NOUN
admet-2334	14	13	)	)	PUNCT
admet-2334	14	14	bridging	bridge	VERB
admet-2334	14	15	classical	classical	ADJ
admet-2334	14	16	medicinal	medicinal	ADJ
admet-2334	14	17	chemistry	chemistry	NOUN
admet-2334	14	18	and	and	CCONJ
admet-2334	14	19	biotechnology	biotechnology	NOUN
admet-2334	14	20	[	[	X
admet-2334	14	21	2,3	2,3	NUM
admet-2334	14	22	]	]	PUNCT
admet-2334	14	23	.	.	PUNCT
admet-2334	15	1	nmcs	nmcs	ADV
admet-2334	15	2	include	include	VERB
admet-2334	15	3	biologics	biologic	NOUN
admet-2334	15	4	(	(	PUNCT
admet-2334	15	5	e.g.	e.g.	ADV
admet-2334	15	6	,	,	PUNCT
admet-2334	15	7	biotech	biotech	NOUN
admet-2334	15	8	-	-	PUNCT
admet-2334	15	9	based	base	VERB
admet-2334	15	10	products	product	NOUN
admet-2334	15	11	such	such	ADJ
admet-2334	15	12	as	as	ADP
admet-2334	15	13	rna	rna	NOUN
admet-2334	15	14	-	-	PUNCT
admet-2334	15	15	based	base	VERB
admet-2334	15	16	therapeutics	therapeutic	NOUN
admet-2334	15	17	and	and	CCONJ
admet-2334	15	18	antibody	antibody	NOUN
admet-2334	15	19	-	-	PUNCT
admet-2334	15	20	drug	drug	NOUN
admet-2334	15	21	conjugates	conjugate	NOUN
admet-2334	15	22	)	)	PUNCT
admet-2334	15	23	and	and	CCONJ
admet-2334	15	24	small	small	ADJ
admet-2334	15	25	molecules	molecule	NOUN
admet-2334	15	26	that	that	PRON
admet-2334	15	27	are	be	AUX
admet-2334	15	28	not	not	PART
admet-2334	15	29	ro5	ro5	ADJ
admet-2334	15	30	compliant	compliant	NOUN
admet-2334	15	31	and	and	CCONJ
admet-2334	15	32	encompass	encompass	VERB
admet-2334	15	33	both	both	CCONJ
admet-2334	15	34	linear	linear	ADJ
admet-2334	15	35	and	and	CCONJ
admet-2334	15	36	cyclic	cyclic	ADJ
admet-2334	15	37	compounds	compound	NOUN
admet-2334	15	38	.	.	PUNCT
admet-2334	16	1	examples	example	NOUN
admet-2334	16	2	of	of	ADP
admet-2334	16	3	linear	linear	PROPN
admet-2334	16	4	derivatives	derivative	NOUN
admet-2334	16	5	are	be	AUX
admet-2334	16	6	targeted	target	VERB
admet-2334	16	7	protein	protein	NOUN
admet-2334	16	8	degraders	degrader	NOUN
admet-2334	16	9	(	(	PUNCT
admet-2334	16	10	tpds	tpds	PROPN
admet-2334	16	11	)	)	PUNCT
admet-2334	16	12	,	,	PUNCT
admet-2334	16	13	which	which	PRON
admet-2334	16	14	include	include	VERB
admet-2334	16	15	proteolysis	proteolysis	NOUN
admet-2334	16	16	targeting	target	VERB
admet-2334	16	17	chimeras	chimera	NOUN
admet-2334	16	18	(	(	PUNCT
admet-2334	16	19	protacs	protacs	PROPN
admet-2334	16	20	)	)	PUNCT
admet-2334	17	1	[	[	X
admet-2334	17	2	4	4	NUM
admet-2334	17	3	]	]	PUNCT
admet-2334	17	4	,	,	PUNCT
admet-2334	17	5	whereas	whereas	SCONJ
admet-2334	17	6	(	(	PUNCT
admet-2334	17	7	mcs	mcs	NOUN
admet-2334	17	8	)	)	PUNCT
admet-2334	17	9	and	and	CCONJ
admet-2334	17	10	cyclic	cyclic	ADJ
admet-2334	17	11	peptides	peptide	NOUN
admet-2334	17	12	(	(	PUNCT
admet-2334	17	13	cps	cp	NOUN
admet-2334	17	14	)	)	PUNCT
admet-2334	17	15	are	be	AUX
admet-2334	17	16	representative	representative	ADJ
admet-2334	17	17	of	of	ADP
admet-2334	17	18	cyclic	cyclic	ADJ
admet-2334	17	19	derivatives	derivative	NOUN
admet-2334	17	20	.	.	PUNCT
admet-2334	18	1	protacs	protac	NOUN
admet-2334	18	2	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	VERB
admet-2334	18	3	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	PRON
admet-2334	18	4	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2334	18	5	mailto:giulia.caron@unito.it	mailto:giulia.caron@unito.it	PROPN
admet-2334	18	6	https://iapchem.org/index.php/iapc-10-home	https://iapchem.org/index.php/iapc-10-home	PROPN
admet-2334	19	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2334	19	2	d.	d.	PROPN
admet-2334	19	3	g.	g.	PROPN
admet-2334	19	4	jiménez	jiménez	PROPN
admet-2334	19	5	et	et	PROPN
admet-2334	19	6	al	al	PROPN
admet-2334	19	7	.	.	PROPN
admet-2334	19	8	admet	admet	PROPN
admet-2334	19	9	&	&	CCONJ
admet-2334	19	10	dmpk	dmpk	PROPN
admet-2334	19	11	12(5	12(5	NUM
admet-2334	19	12	)	)	PUNCT
admet-2334	19	13	(	(	PUNCT
admet-2334	19	14	2024	2024	NUM
admet-2334	19	15	)	)	PUNCT
admet-2334	19	16	721	721	NUM
admet-2334	19	17	-	-	NUM
admet-2334	19	18	736	736	NUM
admet-2334	19	19	722	722	NUM
admet-2334	19	20	consist	consist	NOUN
admet-2334	19	21	of	of	ADP
admet-2334	19	22	two	two	NUM
admet-2334	19	23	linked	link	VERB
admet-2334	19	24	small	small	ADJ
admet-2334	19	25	molecules	molecule	NOUN
admet-2334	19	26	:	:	PUNCT
admet-2334	19	27	one	one	NUM
admet-2334	19	28	binds	bind	VERB
admet-2334	19	29	to	to	ADP
admet-2334	19	30	the	the	DET
admet-2334	19	31	target	target	NOUN
admet-2334	19	32	protein	protein	NOUN
admet-2334	19	33	of	of	ADP
admet-2334	19	34	interest	interest	NOUN
admet-2334	19	35	(	(	PUNCT
admet-2334	19	36	poi	poi	NOUN
admet-2334	19	37	)	)	PUNCT
admet-2334	19	38	,	,	PUNCT
admet-2334	19	39	and	and	CCONJ
admet-2334	19	40	the	the	DET
admet-2334	19	41	other	other	ADJ
admet-2334	19	42	binds	bind	VERB
admet-2334	19	43	to	to	ADP
admet-2334	19	44	an	an	DET
admet-2334	19	45	e3	e3	NOUN
admet-2334	19	46	ligase	ligase	NOUN
admet-2334	19	47	.	.	PUNCT
admet-2334	20	1	tpd	tpd	PROPN
admet-2334	20	2	technology	technology	NOUN
admet-2334	20	3	leverages	leverage	VERB
admet-2334	20	4	the	the	DET
admet-2334	20	5	ubiquitin	ubiquitin	ADJ
admet-2334	20	6	-	-	PUNCT
admet-2334	20	7	proteasome	proteasome	NOUN
admet-2334	20	8	system	system	NOUN
admet-2334	20	9	to	to	PART
admet-2334	20	10	degrade	degrade	VERB
admet-2334	20	11	undesirable	undesirable	ADJ
admet-2334	20	12	proteins	protein	NOUN
admet-2334	20	13	.	.	PUNCT
admet-2334	21	1	mcs	mcs	PROPN
admet-2334	21	2	are	be	AUX
admet-2334	21	3	generally	generally	ADV
admet-2334	21	4	defined	define	VERB
admet-2334	21	5	as	as	ADP
admet-2334	21	6	organic	organic	ADJ
admet-2334	21	7	molecules	molecule	NOUN
admet-2334	21	8	which	which	PRON
admet-2334	21	9	contain	contain	VERB
admet-2334	21	10	a	a	DET
admet-2334	21	11	ring	ring	NOUN
admet-2334	21	12	of	of	ADP
admet-2334	21	13	at	at	ADV
admet-2334	21	14	least	least	ADV
admet-2334	21	15	12	12	NUM
admet-2334	21	16	heavy	heavy	ADJ
admet-2334	21	17	atoms	atom	NOUN
admet-2334	21	18	[	[	X
admet-2334	21	19	5	5	NUM
admet-2334	21	20	]	]	PUNCT
admet-2334	21	21	.	.	PUNCT
admet-2334	22	1	cps	cp	NOUN
admet-2334	22	2	are	be	AUX
admet-2334	22	3	small	small	ADJ
admet-2334	22	4	(	(	PUNCT
admet-2334	22	5	mw	mw	X
admet-2334	22	6	less	less	ADJ
admet-2334	22	7	than	than	ADP
admet-2334	22	8	1500	1500	NUM
admet-2334	22	9	da	da	NOUN
admet-2334	22	10	)	)	PUNCT
admet-2334	22	11	peptides	peptide	NOUN
admet-2334	22	12	cyclized	cyclize	VERB
admet-2334	22	13	to	to	PART
admet-2334	22	14	improve	improve	VERB
admet-2334	22	15	their	their	PRON
admet-2334	22	16	pharmacokinetic	pharmacokinetic	ADJ
admet-2334	22	17	(	(	PUNCT
admet-2334	22	18	pk	pk	NOUN
admet-2334	22	19	)	)	PUNCT
admet-2334	22	20	profile	profile	NOUN
admet-2334	22	21	[	[	X
admet-2334	22	22	6	6	NUM
admet-2334	22	23	]	]	PUNCT
admet-2334	22	24	.	.	PUNCT
admet-2334	23	1	protacs	protacs	PROPN
admet-2334	23	2	,	,	PUNCT
admet-2334	23	3	mcs	mcs	PROPN
admet-2334	23	4	,	,	PUNCT
admet-2334	23	5	and	and	CCONJ
admet-2334	23	6	cps	cps	PROPN
admet-2334	23	7	occupy	occupy	VERB
admet-2334	23	8	a	a	DET
admet-2334	23	9	chemical	chemical	ADJ
admet-2334	23	10	space	space	NOUN
admet-2334	23	11	known	know	VERB
admet-2334	23	12	as	as	ADP
admet-2334	23	13	the	the	DET
admet-2334	23	14	beyond	beyond	NOUN
admet-2334	23	15	-	-	PUNCT
admet-2334	23	16	rule	rule	NOUN
admet-2334	23	17	-	-	PUNCT
admet-2334	23	18	of-5	of-5	PUNCT
admet-2334	23	19	(	(	PUNCT
admet-2334	23	20	bro5	bro5	NOUN
admet-2334	23	21	)	)	PUNCT
admet-2334	23	22	space	space	NOUN
admet-2334	23	23	,	,	PUNCT
admet-2334	23	24	characterized	characterize	VERB
admet-2334	23	25	by	by	ADP
admet-2334	23	26	a	a	DET
admet-2334	23	27	molecular	molecular	ADJ
admet-2334	23	28	weight	weight	NOUN
admet-2334	23	29	(	(	PUNCT
admet-2334	23	30	mw	mw	NOUN
admet-2334	23	31	)	)	PUNCT
admet-2334	23	32	ranging	range	VERB
admet-2334	23	33	from	from	ADP
admet-2334	23	34	approximately	approximately	ADV
admet-2334	23	35	500	500	NUM
admet-2334	23	36	to	to	PART
admet-2334	23	37	1500	1500	NUM
admet-2334	23	38	da	da	NOUN
admet-2334	23	39	(	(	PUNCT
admet-2334	23	40	figure	figure	NOUN
admet-2334	23	41	1a	1a	NOUN
admet-2334	23	42	)	)	PUNCT
admet-2334	23	43	.	.	PUNCT
admet-2334	24	1	this	this	DET
admet-2334	24	2	space	space	NOUN
admet-2334	24	3	is	be	AUX
admet-2334	24	4	situated	situate	VERB
admet-2334	24	5	between	between	ADP
admet-2334	24	6	ro5	ro5	ADJ
admet-2334	24	7	-	-	PUNCT
admet-2334	24	8	compliant	compliant	ADJ
admet-2334	24	9	drugs	drug	NOUN
admet-2334	24	10	and	and	CCONJ
admet-2334	24	11	biologics	biologic	NOUN
admet-2334	24	12	.	.	PUNCT
admet-2334	25	1	notably	notably	ADV
admet-2334	25	2	,	,	PUNCT
admet-2334	25	3	an	an	DET
admet-2334	25	4	increase	increase	NOUN
admet-2334	25	5	in	in	ADP
admet-2334	25	6	mw	mw	NOUN
admet-2334	25	7	often	often	ADV
admet-2334	25	8	correlates	correlate	VERB
admet-2334	25	9	with	with	ADP
admet-2334	25	10	reduced	reduce	VERB
admet-2334	25	11	solubility	solubility	NOUN
admet-2334	25	12	and	and	CCONJ
admet-2334	25	13	membrane	membrane	NOUN
admet-2334	25	14	permeability	permeability	NOUN
admet-2334	25	15	.	.	PUNCT
admet-2334	26	1	this	this	DET
admet-2334	26	2	reduction	reduction	NOUN
admet-2334	26	3	is	be	AUX
admet-2334	26	4	also	also	ADV
admet-2334	26	5	linked	link	VERB
admet-2334	26	6	to	to	ADP
admet-2334	26	7	the	the	DET
admet-2334	26	8	tendency	tendency	NOUN
admet-2334	26	9	of	of	ADP
admet-2334	26	10	high	high	ADJ
admet-2334	26	11	-	-	PUNCT
admet-2334	26	12	mw	mw	NOUN
admet-2334	26	13	molecules	molecule	NOUN
admet-2334	26	14	to	to	PART
admet-2334	26	15	trigger	trigger	NOUN
admet-2334	26	16	efflux	efflux	NOUN
admet-2334	26	17	pumps	pump	NOUN
admet-2334	26	18	,	,	PUNCT
admet-2334	26	19	such	such	ADJ
admet-2334	26	20	as	as	ADP
admet-2334	26	21	p	p	NOUN
admet-2334	26	22	-	-	PUNCT
admet-2334	26	23	glycoprotein	glycoprotein	NOUN
admet-2334	26	24	(	(	PUNCT
admet-2334	26	25	p	p	NOUN
admet-2334	26	26	-	-	PUNCT
admet-2334	26	27	gp	gp	NOUN
admet-2334	26	28	)	)	PUNCT
admet-2334	26	29	,	,	PUNCT
admet-2334	26	30	which	which	PRON
admet-2334	26	31	expel	expel	VERB
admet-2334	26	32	drugs	drug	NOUN
admet-2334	26	33	from	from	ADP
admet-2334	26	34	cells	cell	NOUN
admet-2334	26	35	[	[	X
admet-2334	26	36	7	7	NUM
admet-2334	26	37	]	]	PUNCT
admet-2334	26	38	.	.	PUNCT
admet-2334	27	1	figure	figure	NOUN
admet-2334	27	2	1	1	NUM
admet-2334	27	3	.	.	PUNCT
admet-2334	28	1	(	(	PUNCT
admet-2334	28	2	a	a	X
admet-2334	28	3	)	)	PUNCT
admet-2334	28	4	the	the	DET
admet-2334	28	5	bro5	bro5	NOUN
admet-2334	28	6	chemical	chemical	NOUN
admet-2334	28	7	space	space	NOUN
admet-2334	28	8	classification	classification	NOUN
admet-2334	28	9	with	with	ADP
admet-2334	28	10	three	three	NUM
admet-2334	28	11	representative	representative	ADJ
admet-2334	28	12	compounds	compound	NOUN
admet-2334	28	13	,	,	PUNCT
admet-2334	28	14	the	the	DET
admet-2334	28	15	cyclopeptide	cyclopeptide	ADJ
admet-2334	28	16	cyclosporin	cyclosporin	NOUN
admet-2334	28	17	a	a	PROPN
admet-2334	28	18	,	,	PUNCT
admet-2334	28	19	the	the	DET
admet-2334	28	20	macrocycle	macrocycle	NOUN
admet-2334	28	21	rifampicin	rifampicin	VERB
admet-2334	28	22	and	and	CCONJ
admet-2334	28	23	the	the	DET
admet-2334	28	24	protac	protac	ADJ
admet-2334	28	25	bavdegalutamide	bavdegalutamide	NOUN
admet-2334	28	26	(	(	PUNCT
admet-2334	28	27	arv-110	arv-110	NOUN
admet-2334	28	28	)	)	PUNCT
admet-2334	28	29	.	.	PUNCT
admet-2334	29	1	(	(	PUNCT
admet-2334	29	2	b	b	X
admet-2334	29	3	)	)	PUNCT
admet-2334	29	4	plot	plot	NOUN
admet-2334	29	5	built	build	VERB
admet-2334	29	6	using	use	VERB
admet-2334	29	7	data	datum	NOUN
admet-2334	29	8	taken	take	VERB
admet-2334	29	9	from	from	ADP
admet-2334	29	10	zhu	zhu	PROPN
admet-2334	29	11	et	et	PROPN
admet-2334	29	12	al	al	PROPN
admet-2334	29	13	.	.	PUNCT
admet-2334	30	1	[	[	X
admet-2334	30	2	8	8	NUM
admet-2334	30	3	]	]	PUNCT
admet-2334	30	4	and	and	CCONJ
admet-2334	30	5	demonstrating	demonstrate	VERB
admet-2334	30	6	the	the	DET
admet-2334	30	7	feasibility	feasibility	NOUN
admet-2334	30	8	of	of	ADP
admet-2334	30	9	discovering	discover	VERB
admet-2334	30	10	oral	oral	ADJ
admet-2334	30	11	bioavailable	bioavailable	ADJ
admet-2334	30	12	protacs	protac	NOUN
admet-2334	30	13	.	.	PUNCT
admet-2334	31	1	bro5	bro5	NOUN
admet-2334	31	2	molecules	molecule	NOUN
admet-2334	31	3	can	can	AUX
admet-2334	31	4	show	show	VERB
admet-2334	31	5	either	either	CCONJ
admet-2334	31	6	high	high	ADJ
admet-2334	31	7	lipophilicity	lipophilicity	NOUN
admet-2334	31	8	(	(	PUNCT
admet-2334	31	9	e.g.	e.g.	ADV
admet-2334	31	10	,	,	PUNCT
admet-2334	31	11	macrocycles	macrocycle	NOUN
admet-2334	31	12	)	)	PUNCT
admet-2334	31	13	or	or	CCONJ
admet-2334	31	14	high	high	ADJ
admet-2334	31	15	polarity	polarity	NOUN
admet-2334	31	16	(	(	PUNCT
admet-2334	31	17	e.g.	e.g.	ADV
admet-2334	31	18	,	,	PUNCT
admet-2334	31	19	cyclopeptides	cyclopeptide	NOUN
admet-2334	31	20	)	)	PUNCT
admet-2334	31	21	.	.	PUNCT
admet-2334	32	1	high	high	ADJ
admet-2334	32	2	polarity	polarity	NOUN
admet-2334	32	3	,	,	PUNCT
admet-2334	32	4	as	as	SCONJ
admet-2334	32	5	indicated	indicate	VERB
admet-2334	32	6	by	by	ADP
admet-2334	32	7	metrics	metric	NOUN
admet-2334	32	8	like	like	ADP
admet-2334	32	9	hydrogen	hydrogen	NOUN
admet-2334	32	10	bond	bond	NOUN
admet-2334	32	11	donors	donor	NOUN
admet-2334	32	12	(	(	PUNCT
admet-2334	32	13	hbds	hbds	NOUN
admet-2334	32	14	)	)	PUNCT
admet-2334	32	15	,	,	PUNCT
admet-2334	32	16	hydrogen	hydrogen	NOUN
admet-2334	32	17	bond	bond	NOUN
admet-2334	32	18	acceptors	acceptor	NOUN
admet-2334	32	19	(	(	PUNCT
admet-2334	32	20	hbas	hbas	NOUN
admet-2334	32	21	)	)	PUNCT
admet-2334	32	22	,	,	PUNCT
admet-2334	32	23	and	and	CCONJ
admet-2334	32	24	topological	topological	ADJ
admet-2334	32	25	polar	polar	ADJ
admet-2334	32	26	surface	surface	NOUN
admet-2334	32	27	area	area	NOUN
admet-2334	32	28	(	(	PUNCT
admet-2334	32	29	tpsa	tpsa	PROPN
admet-2334	32	30	)	)	PUNCT
admet-2334	32	31	,	,	PUNCT
admet-2334	32	32	can	can	AUX
admet-2334	32	33	enhance	enhance	VERB
admet-2334	32	34	solubility	solubility	NOUN
admet-2334	32	35	but	but	CCONJ
admet-2334	32	36	reduce	reduce	VERB
admet-2334	32	37	cell	cell	NOUN
admet-2334	32	38	permeability	permeability	NOUN
admet-2334	32	39	.	.	PUNCT
admet-2334	33	1	conversely	conversely	ADV
admet-2334	33	2	,	,	PUNCT
admet-2334	33	3	high	high	ADJ
admet-2334	33	4	lipophilicity	lipophilicity	NOUN
admet-2334	33	5	promotes	promote	VERB
admet-2334	33	6	cell	cell	NOUN
admet-2334	33	7	permeability	permeability	NOUN
admet-2334	33	8	but	but	CCONJ
admet-2334	33	9	hampers	hamper	VERB
admet-2334	33	10	solubility	solubility	NOUN
admet-2334	33	11	.	.	PUNCT
admet-2334	34	1	additionally	additionally	ADV
admet-2334	34	2	,	,	PUNCT
admet-2334	34	3	excessively	excessively	ADV
admet-2334	34	4	high	high	ADJ
admet-2334	34	5	lipophilicity	lipophilicity	NOUN
admet-2334	34	6	,	,	PUNCT
admet-2334	34	7	often	often	ADV
admet-2334	34	8	quantified	quantify	VERB
admet-2334	34	9	by	by	ADP
admet-2334	34	10	clogp	clogp	NOUN
admet-2334	34	11	,	,	PUNCT
admet-2334	34	12	where	where	SCONJ
admet-2334	34	13	c	c	PROPN
admet-2334	34	14	indicates	indicate	VERB
admet-2334	34	15	any	any	DET
admet-2334	34	16	calculation	calculation	NOUN
admet-2334	34	17	method	method	NOUN
admet-2334	34	18	,	,	PUNCT
admet-2334	34	19	can	can	AUX
admet-2334	34	20	lead	lead	VERB
admet-2334	34	21	to	to	ADP
admet-2334	34	22	nmcs	nmcs	ADV
admet-2334	34	23	include	include	VERB
admet-2334	34	24	retention	retention	NOUN
admet-2334	34	25	,	,	PUNCT
admet-2334	34	26	compromising	compromise	VERB
admet-2334	34	27	oral	oral	ADJ
admet-2334	34	28	bioavailability	bioavailability	NOUN
admet-2334	34	29	and	and	CCONJ
admet-2334	34	30	increasing	increase	VERB
admet-2334	34	31	metabolic	metabolic	NOUN
admet-2334	34	32	clearance	clearance	NOUN
admet-2334	34	33	and	and	CCONJ
admet-2334	34	34	overall	overall	ADJ
admet-2334	34	35	toxicity	toxicity	NOUN
admet-2334	34	36	.	.	PUNCT
admet-2334	35	1	achieving	achieve	VERB
admet-2334	35	2	an	an	DET
admet-2334	35	3	optimal	optimal	ADJ
admet-2334	35	4	balance	balance	NOUN
admet-2334	35	5	between	between	ADP
admet-2334	35	6	polarity	polarity	NOUN
admet-2334	35	7	and	and	CCONJ
admet-2334	35	8	lipophilicity	lipophilicity	NOUN
admet-2334	35	9	is	be	AUX
admet-2334	35	10	therefore	therefore	ADV
admet-2334	35	11	challenging	challenge	VERB
admet-2334	35	12	for	for	ADP
admet-2334	35	13	bro5	bro5	NOUN
admet-2334	35	14	derivatives	derivative	NOUN
admet-2334	35	15	.	.	PUNCT
admet-2334	36	1	bro5	bro5	NOUN
admet-2334	36	2	compounds	compound	NOUN
admet-2334	36	3	often	often	ADV
admet-2334	36	4	show	show	VERB
admet-2334	36	5	a	a	DET
admet-2334	36	6	flexible	flexible	ADJ
admet-2334	36	7	structure	structure	NOUN
admet-2334	36	8	.	.	PUNCT
admet-2334	37	1	notably	notably	ADV
admet-2334	37	2	,	,	PUNCT
admet-2334	37	3	high	high	ADJ
admet-2334	37	4	flexibility	flexibility	NOUN
admet-2334	37	5	complemented	complement	VERB
admet-2334	37	6	with	with	ADP
admet-2334	37	7	structural	structural	ADJ
admet-2334	37	8	complexity	complexity	NOUN
admet-2334	37	9	confers	confer	NOUN
admet-2334	37	10	to	to	ADP
admet-2334	37	11	some	some	DET
admet-2334	37	12	bro5	bro5	NOUN
admet-2334	37	13	compounds	compound	VERB
admet-2334	37	14	the	the	DET
admet-2334	37	15	ability	ability	NOUN
admet-2334	37	16	to	to	PART
admet-2334	37	17	adopt	adopt	VERB
admet-2334	37	18	different	different	ADJ
admet-2334	37	19	environment	environment	NOUN
admet-2334	37	20	-	-	PUNCT
admet-2334	37	21	dependent	dependent	ADJ
admet-2334	37	22	conformations	conformation	NOUN
admet-2334	37	23	.	.	PUNCT
admet-2334	38	1	molecular	molecular	ADJ
admet-2334	38	2	flexibility	flexibility	NOUN
admet-2334	38	3	is	be	AUX
admet-2334	38	4	typically	typically	ADV
admet-2334	38	5	expressed	express	VERB
admet-2334	38	6	as	as	ADP
admet-2334	38	7	the	the	DET
admet-2334	38	8	number	number	NOUN
admet-2334	38	9	of	of	ADP
admet-2334	38	10	rotatable	rotatable	ADJ
admet-2334	38	11	bonds	bond	NOUN
admet-2334	38	12	(	(	PUNCT
admet-2334	38	13	nrot	nrot	NOUN
admet-2334	38	14	)	)	PUNCT
admet-2334	38	15	.	.	PUNCT
admet-2334	39	1	however	however	ADV
admet-2334	39	2	,	,	PUNCT
admet-2334	39	3	the	the	DET
admet-2334	39	4	kier	kier	PROPN
admet-2334	39	5	flexibility	flexibility	NOUN
admet-2334	39	6	descriptor	descriptor	NOUN
admet-2334	39	7	phi	phi	NOUN
admet-2334	39	8	is	be	AUX
admet-2334	39	9	the	the	DET
admet-2334	39	10	only	only	ADJ
admet-2334	39	11	general	general	ADJ
admet-2334	39	12	quantifier	quantifier	NOUN
admet-2334	39	13	that	that	PRON
admet-2334	39	14	remains	remain	VERB
admet-2334	39	15	valid	valid	ADJ
admet-2334	39	16	even	even	ADV
admet-2334	39	17	when	when	SCONJ
admet-2334	39	18	macrocyclic	macrocyclic	NOUN
admet-2334	39	19	substructures	substructure	NOUN
admet-2334	39	20	are	be	AUX
admet-2334	39	21	present	present	ADJ
admet-2334	39	22	[	[	X
admet-2334	39	23	9	9	NUM
admet-2334	39	24	]	]	PUNCT
admet-2334	39	25	.	.	PUNCT
admet-2334	40	1	in	in	ADP
admet-2334	40	2	summary	summary	NOUN
admet-2334	40	3	,	,	PUNCT
admet-2334	40	4	bro5	bro5	NOUN
admet-2334	40	5	compounds	compound	NOUN
admet-2334	40	6	exhibit	exhibit	VERB
admet-2334	40	7	distinctive	distinctive	ADJ
admet-2334	40	8	molecular	molecular	ADJ
admet-2334	40	9	characteristics	characteristic	NOUN
admet-2334	40	10	that	that	PRON
admet-2334	40	11	undermine	undermine	VERB
admet-2334	40	12	the	the	DET
admet-2334	40	13	efficacy	efficacy	NOUN
admet-2334	40	14	of	of	ADP
admet-2334	40	15	traditional	traditional	ADJ
admet-2334	40	16	property	property	NOUN
admet-2334	40	17	-	-	PUNCT
admet-2334	40	18	based	base	VERB
admet-2334	40	19	drug	drug	NOUN
admet-2334	40	20	discovery	discovery	NOUN
admet-2334	40	21	approaches	approach	NOUN
admet-2334	40	22	tailored	tailor	VERB
admet-2334	40	23	for	for	ADP
admet-2334	40	24	ro5	ro5	ADJ
admet-2334	40	25	molecules	molecule	NOUN
admet-2334	40	26	[	[	X
admet-2334	40	27	10	10	NUM
admet-2334	40	28	]	]	PUNCT
admet-2334	40	29	.	.	PUNCT
admet-2334	41	1	however	however	ADV
admet-2334	41	2	,	,	PUNCT
admet-2334	41	3	some	some	DET
admet-2334	41	4	bro5	bro5	NOUN
admet-2334	41	5	drugs	drug	NOUN
admet-2334	41	6	have	have	AUX
admet-2334	41	7	shown	show	VERB
admet-2334	41	8	satisfactory	satisfactory	ADJ
admet-2334	41	9	oral	oral	ADJ
admet-2334	41	10	bioavailability	bioavailability	NOUN
admet-2334	41	11	and	and	CCONJ
admet-2334	41	12	have	have	AUX
admet-2334	41	13	been	be	AUX
admet-2334	41	14	approved	approve	VERB
admet-2334	41	15	for	for	ADP
admet-2334	41	16	oral	oral	ADJ
admet-2334	41	17	formulations	formulation	NOUN
admet-2334	41	18	(	(	PUNCT
admet-2334	41	19	figure	figure	NOUN
admet-2334	41	20	1b	1b	NUM
admet-2334	41	21	)	)	PUNCT
admet-2334	42	1	[	[	X
admet-2334	42	2	11	11	NUM
admet-2334	42	3	]	]	PUNCT
admet-2334	42	4	.	.	PUNCT
admet-2334	43	1	chameleonicity	chameleonicity	PROPN
admet-2334	43	2	should	should	AUX
admet-2334	43	3	be	be	AUX
admet-2334	43	4	introduced	introduce	VERB
admet-2334	43	5	in	in	ADP
admet-2334	43	6	the	the	DET
admet-2334	43	7	pool	pool	NOUN
admet-2334	43	8	of	of	ADP
admet-2334	43	9	bro5	bro5	NOUN
admet-2334	43	10	molecular	molecular	ADJ
admet-2334	43	11	properties	property	NOUN
admet-2334	43	12	it	it	PRON
admet-2334	43	13	has	have	AUX
admet-2334	43	14	been	be	AUX
admet-2334	43	15	shown	show	VERB
admet-2334	43	16	that	that	SCONJ
admet-2334	43	17	a	a	DET
admet-2334	43	18	few	few	ADJ
admet-2334	43	19	bro5	bro5	NOUN
admet-2334	43	20	compounds	compound	NOUN
admet-2334	43	21	have	have	VERB
admet-2334	43	22	the	the	DET
admet-2334	43	23	ability	ability	NOUN
admet-2334	43	24	to	to	PART
admet-2334	43	25	alter	alter	VERB
admet-2334	43	26	their	their	PRON
admet-2334	43	27	conformations	conformation	NOUN
admet-2334	43	28	and	and	CCONJ
admet-2334	43	29	molecular	molecular	ADJ
admet-2334	43	30	characteristics	characteristic	NOUN
admet-2334	43	31	depending	depend	VERB
admet-2334	43	32	on	on	ADP
admet-2334	43	33	the	the	DET
admet-2334	43	34	surrounding	surround	VERB
admet-2334	43	35	environment	environment	NOUN
admet-2334	43	36	.	.	PUNCT
admet-2334	44	1	this	this	DET
admet-2334	44	2	phenomenon	phenomenon	NOUN
admet-2334	44	3	,	,	PUNCT
admet-2334	44	4	initially	initially	ADV
admet-2334	44	5	observed	observe	VERB
admet-2334	44	6	by	by	ADP
admet-2334	44	7	carrupt	carrupt	NOUN
admet-2334	44	8	and	and	CCONJ
admet-2334	44	9	colleagues	colleague	NOUN
admet-2334	44	10	in	in	ADP
admet-2334	44	11	1991	1991	NUM
admet-2334	44	12	[	[	X
admet-2334	44	13	12	12	NUM
admet-2334	44	14	]	]	PUNCT
admet-2334	44	15	,	,	PUNCT
admet-2334	44	16	was	be	AUX
admet-2334	44	17	termed	term	VERB
admet-2334	44	18	"	"	PUNCT
admet-2334	44	19	chameleonicity	chameleonicity	NOUN
admet-2334	44	20	"	"	PUNCT
admet-2334	44	21	.	.	PUNCT
admet-2334	45	1	formally	formally	ADV
admet-2334	45	2	defined	define	VERB
admet-2334	45	3	,	,	PUNCT
admet-2334	45	4	chameleonicity	chameleonicity	NOUN
admet-2334	45	5	refers	refer	VERB
admet-2334	45	6	to	to	ADP
admet-2334	45	7	a	a	DET
admet-2334	45	8	compound	compound	NOUN
admet-2334	45	9	's	's	PART
admet-2334	45	10	capacity	capacity	NOUN
admet-2334	45	11	to	to	PART
admet-2334	45	12	adopt	adopt	VERB
admet-2334	45	13	open	open	ADJ
admet-2334	45	14	and	and	CCONJ
admet-2334	45	15	polar	polar	ADJ
admet-2334	45	16	conformations	conformation	NOUN
admet-2334	45	17	in	in	ADP
admet-2334	45	18	aqueous	aqueous	ADJ
admet-2334	45	19	environments	environment	NOUN
admet-2334	45	20	while	while	SCONJ
admet-2334	45	21	assuming	assume	VERB
admet-2334	45	22	ba	ba	PROPN
admet-2334	45	23	admet	admet	PROPN
admet-2334	45	24	&	&	CCONJ
admet-2334	45	25	dmpk	dmpk	PROPN
admet-2334	45	26	12(5	12(5	NUM
admet-2334	45	27	)	)	PUNCT
admet-2334	45	28	(	(	PUNCT
admet-2334	45	29	2024	2024	NUM
admet-2334	45	30	)	)	PUNCT
admet-2334	45	31	721	721	NUM
admet-2334	45	32	-	-	NUM
admet-2334	45	33	736	736	NUM
admet-2334	45	34	designing	design	VERB
admet-2334	45	35	the	the	DET
admet-2334	45	36	next	next	ADJ
admet-2334	45	37	generation	generation	NOUN
admet-2334	45	38	of	of	ADP
admet-2334	45	39	oral	oral	ADJ
admet-2334	45	40	beyond	beyond	ADP
admet-2334	45	41	rule	rule	NOUN
admet-2334	45	42	of	of	ADP
admet-2334	45	43	five	five	NUM
admet-2334	45	44	drugs	drug	NOUN
admet-2334	45	45	doi	doi	NOUN
admet-2334	45	46	:	:	PUNCT
admet-2334	45	47	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	NOUN
admet-2334	45	48	723	723	NUM
admet-2334	45	49	folded	fold	VERB
admet-2334	45	50	and	and	CCONJ
admet-2334	45	51	less	less	ADV
admet-2334	45	52	polar	polar	ADJ
admet-2334	45	53	conformations	conformation	NOUN
admet-2334	45	54	in	in	ADP
admet-2334	45	55	nonpolar	nonpolar	ADJ
admet-2334	45	56	environments	environment	NOUN
admet-2334	45	57	such	such	ADJ
admet-2334	45	58	as	as	ADP
admet-2334	45	59	cellular	cellular	ADJ
admet-2334	45	60	membranes	membrane	NOUN
admet-2334	45	61	.	.	PUNCT
admet-2334	46	1	in	in	ADP
admet-2334	46	2	practice	practice	NOUN
admet-2334	46	3	,	,	PUNCT
admet-2334	46	4	chameleonicity	chameleonicity	NOUN
admet-2334	46	5	arises	arise	VERB
admet-2334	46	6	from	from	ADP
admet-2334	46	7	conformational	conformational	ADJ
admet-2334	46	8	changes	change	NOUN
admet-2334	46	9	that	that	PRON
admet-2334	46	10	modify	modify	VERB
admet-2334	46	11	the	the	DET
admet-2334	46	12	molecular	molecular	ADJ
admet-2334	46	13	properties	property	NOUN
admet-2334	46	14	of	of	ADP
admet-2334	46	15	a	a	DET
admet-2334	46	16	compound	compound	NOUN
admet-2334	46	17	in	in	ADP
admet-2334	46	18	an	an	DET
admet-2334	46	19	environment	environment	NOUN
admet-2334	46	20	-	-	PUNCT
admet-2334	46	21	dependent	dependent	ADJ
admet-2334	46	22	manner	manner	NOUN
admet-2334	46	23	.	.	PUNCT
admet-2334	47	1	the	the	DET
admet-2334	47	2	first	first	ADJ
admet-2334	47	3	and	and	CCONJ
admet-2334	47	4	most	most	ADV
admet-2334	47	5	well	well	ADV
admet-2334	47	6	-	-	PUNCT
admet-2334	47	7	known	know	VERB
admet-2334	47	8	chameleonicity	chameleonicity	NOUN
admet-2334	47	9	mechanism	mechanism	NOUN
admet-2334	47	10	is	be	AUX
admet-2334	47	11	the	the	DET
admet-2334	47	12	formation	formation	NOUN
admet-2334	47	13	of	of	ADP
admet-2334	47	14	dynamic	dynamic	ADJ
admet-2334	47	15	intramolecular	intramolecular	ADJ
admet-2334	47	16	hydrogen	hydrogen	NOUN
admet-2334	47	17	bonds	bond	NOUN
admet-2334	47	18	(	(	PUNCT
admet-2334	47	19	dimhbs	dimhbs	PROPN
admet-2334	47	20	)	)	PUNCT
admet-2334	47	21	.	.	PUNCT
admet-2334	48	1	in	in	ADP
admet-2334	48	2	2011	2011	NUM
admet-2334	48	3	,	,	PUNCT
admet-2334	48	4	alex	alex	PROPN
admet-2334	48	5	et	et	PROPN
admet-2334	48	6	al	al	PROPN
admet-2334	48	7	.	.	PUNCT
admet-2334	49	1	[	[	X
admet-2334	49	2	13	13	NUM
admet-2334	49	3	]	]	PUNCT
admet-2334	49	4	conducted	conduct	VERB
admet-2334	49	5	a	a	DET
admet-2334	49	6	study	study	NOUN
admet-2334	49	7	analysing	analyse	VERB
admet-2334	49	8	the	the	DET
admet-2334	49	9	experimental	experimental	ADJ
admet-2334	49	10	conformations	conformation	NOUN
admet-2334	49	11	of	of	ADP
admet-2334	49	12	cyclosporin	cyclosporin	NOUN
admet-2334	49	13	a	a	PRON
admet-2334	49	14	(	(	PUNCT
admet-2334	49	15	csa	csa	PROPN
admet-2334	49	16	)	)	PUNCT
admet-2334	49	17	derived	derive	VERB
admet-2334	49	18	from	from	ADP
admet-2334	49	19	x	x	ADJ
admet-2334	49	20	-	-	NOUN
admet-2334	49	21	ray	ray	NOUN
admet-2334	49	22	crystallography	crystallography	NOUN
admet-2334	49	23	and	and	CCONJ
admet-2334	49	24	nmr	nmr	NOUN
admet-2334	49	25	spectroscopy	spectroscopy	NOUN
admet-2334	49	26	.	.	PUNCT
admet-2334	50	1	in	in	ADP
admet-2334	50	2	water	water	NOUN
admet-2334	50	3	,	,	PUNCT
admet-2334	50	4	csa	csa	PROPN
admet-2334	50	5	forms	form	VERB
admet-2334	50	6	hydrogen	hydrogen	NOUN
admet-2334	50	7	bonds	bond	NOUN
admet-2334	50	8	(	(	PUNCT
admet-2334	50	9	hbs	hbs	PROPN
admet-2334	50	10	)	)	PUNCT
admet-2334	50	11	with	with	ADP
admet-2334	50	12	the	the	DET
admet-2334	50	13	solvent	solvent	NOUN
admet-2334	50	14	,	,	PUNCT
admet-2334	50	15	adopting	adopt	VERB
admet-2334	50	16	an	an	DET
admet-2334	50	17	open	open	ADJ
admet-2334	50	18	and	and	CCONJ
admet-2334	50	19	more	more	ADV
admet-2334	50	20	polar	polar	ADJ
admet-2334	50	21	conformation	conformation	NOUN
admet-2334	50	22	.	.	PUNCT
admet-2334	51	1	in	in	ADP
admet-2334	51	2	nonpolar	nonpolar	ADJ
admet-2334	51	3	solvents	solvent	NOUN
admet-2334	51	4	,	,	PUNCT
admet-2334	51	5	the	the	DET
admet-2334	51	6	hbs	hbs	PROPN
admet-2334	51	7	are	be	AUX
admet-2334	51	8	established	establish	VERB
admet-2334	51	9	within	within	ADP
admet-2334	51	10	the	the	DET
admet-2334	51	11	csa	csa	PROPN
admet-2334	51	12	structure	structure	NOUN
admet-2334	51	13	,	,	PUNCT
admet-2334	51	14	resulting	result	VERB
admet-2334	51	15	in	in	ADP
admet-2334	51	16	a	a	DET
admet-2334	51	17	closed	closed	ADJ
admet-2334	51	18	and	and	CCONJ
admet-2334	51	19	less	less	ADV
admet-2334	51	20	polar	polar	ADJ
admet-2334	51	21	conformation	conformation	NOUN
admet-2334	51	22	.	.	PUNCT
admet-2334	52	1	consequently	consequently	ADV
admet-2334	52	2	,	,	PUNCT
admet-2334	52	3	the	the	DET
admet-2334	52	4	formation	formation	NOUN
admet-2334	52	5	of	of	ADP
admet-2334	52	6	these	these	DET
admet-2334	52	7	dimhbs	dimhbs	NOUN
admet-2334	52	8	(	(	PUNCT
admet-2334	52	9	dynamic	dynamic	ADJ
admet-2334	52	10	since	since	SCONJ
admet-2334	52	11	formed	form	VERB
admet-2334	52	12	only	only	ADV
admet-2334	52	13	in	in	ADP
admet-2334	52	14	the	the	DET
admet-2334	52	15	nonpolar	nonpolar	ADJ
admet-2334	52	16	environment	environment	NOUN
admet-2334	52	17	)	)	PUNCT
admet-2334	52	18	resulted	result	VERB
admet-2334	52	19	in	in	ADP
admet-2334	52	20	a	a	DET
admet-2334	52	21	conformational	conformational	ADJ
admet-2334	52	22	change	change	NOUN
admet-2334	52	23	from	from	ADP
admet-2334	52	24	an	an	DET
admet-2334	52	25	open	open	ADJ
admet-2334	52	26	conformation	conformation	NOUN
admet-2334	52	27	in	in	ADP
admet-2334	52	28	the	the	DET
admet-2334	52	29	cytosol	cytosol	NOUN
admet-2334	52	30	to	to	ADP
admet-2334	52	31	a	a	DET
admet-2334	52	32	closed	closed	ADJ
admet-2334	52	33	conformation	conformation	NOUN
admet-2334	52	34	within	within	ADP
admet-2334	52	35	the	the	DET
admet-2334	52	36	membrane	membrane	NOUN
admet-2334	52	37	interior	interior	NOUN
admet-2334	52	38	.	.	PUNCT
admet-2334	53	1	it	it	PRON
admet-2334	53	2	was	be	AUX
admet-2334	53	3	postulated	postulate	VERB
admet-2334	53	4	that	that	SCONJ
admet-2334	53	5	this	this	DET
admet-2334	53	6	chameleonic	chameleonic	ADJ
admet-2334	53	7	behaviour	behaviour	NOUN
admet-2334	53	8	could	could	AUX
admet-2334	53	9	be	be	AUX
admet-2334	53	10	the	the	DET
admet-2334	53	11	key	key	ADJ
admet-2334	53	12	factor	factor	NOUN
admet-2334	53	13	underlying	underlie	VERB
admet-2334	53	14	the	the	DET
admet-2334	53	15	unexpectedly	unexpectedly	ADV
admet-2334	53	16	high	high	ADJ
admet-2334	53	17	permeability	permeability	NOUN
admet-2334	53	18	of	of	ADP
admet-2334	53	19	csa	csa	PROPN
admet-2334	54	1	[	[	X
admet-2334	54	2	13	13	NUM
admet-2334	54	3	]	]	PUNCT
admet-2334	54	4	.	.	PUNCT
admet-2334	55	1	in	in	ADP
admet-2334	55	2	practice	practice	NOUN
admet-2334	55	3	,	,	PUNCT
admet-2334	55	4	csa	csa	PROPN
admet-2334	55	5	is	be	AUX
admet-2334	55	6	the	the	DET
admet-2334	55	7	first	first	ADJ
admet-2334	55	8	wellunderstood	wellunderstood	NOUN
admet-2334	55	9	example	example	NOUN
admet-2334	55	10	of	of	ADP
admet-2334	55	11	a	a	DET
admet-2334	55	12	bro5	bro5	NOUN
admet-2334	55	13	drug	drug	NOUN
admet-2334	55	14	possessing	possess	VERB
admet-2334	55	15	adequate	adequate	ADJ
admet-2334	55	16	solubility	solubility	NOUN
admet-2334	55	17	and	and	CCONJ
admet-2334	55	18	cell	cell	NOUN
admet-2334	55	19	permeability	permeability	NOUN
admet-2334	55	20	to	to	PART
admet-2334	55	21	transition	transition	VERB
admet-2334	55	22	into	into	ADP
admet-2334	55	23	an	an	DET
admet-2334	55	24	oral	oral	ADJ
admet-2334	55	25	medication	medication	NOUN
admet-2334	55	26	through	through	ADP
admet-2334	55	27	molecular	molecular	ADJ
admet-2334	55	28	chameleonicity	chameleonicity	NOUN
admet-2334	55	29	.	.	PUNCT
admet-2334	56	1	solubility	solubility	NOUN
admet-2334	56	2	,	,	PUNCT
admet-2334	56	3	permeability	permeability	NOUN
admet-2334	56	4	and	and	CCONJ
admet-2334	56	5	metabolic	metabolic	NOUN
admet-2334	56	6	stability	stability	NOUN
admet-2334	56	7	are	be	AUX
admet-2334	56	8	in	in	ADP
admet-2334	56	9	vitro	vitro	X
admet-2334	56	10	adme	adme	NOUN
admet-2334	56	11	properties	property	NOUN
admet-2334	56	12	that	that	PRON
admet-2334	56	13	impact	impact	VERB
admet-2334	56	14	oral	oral	ADJ
admet-2334	56	15	bioavailability	bioavailability	NOUN
admet-2334	56	16	(	(	PUNCT
admet-2334	56	17	figure	figure	NOUN
admet-2334	56	18	2	2	NUM
admet-2334	56	19	)	)	PUNCT
admet-2334	56	20	.	.	PUNCT
admet-2334	57	1	these	these	DET
admet-2334	57	2	latter	latter	ADJ
admet-2334	57	3	are	be	AUX
admet-2334	57	4	in	in	ADP
admet-2334	57	5	turn	turn	NOUN
admet-2334	57	6	modulated	modulate	VERB
admet-2334	57	7	by	by	ADP
admet-2334	57	8	physicochemical	physicochemical	ADJ
admet-2334	57	9	properties	property	NOUN
admet-2334	57	10	like	like	ADP
admet-2334	57	11	ionization	ionization	NOUN
admet-2334	57	12	,	,	PUNCT
admet-2334	57	13	size	size	NOUN
admet-2334	57	14	and	and	CCONJ
admet-2334	57	15	shape	shape	NOUN
admet-2334	57	16	,	,	PUNCT
admet-2334	57	17	lipophilicity	lipophilicity	NOUN
admet-2334	57	18	and	and	CCONJ
admet-2334	57	19	polarity	polarity	NOUN
admet-2334	57	20	.	.	PUNCT
admet-2334	58	1	according	accord	VERB
admet-2334	58	2	to	to	ADP
admet-2334	58	3	the	the	DET
admet-2334	58	4	previous	previous	ADJ
admet-2334	58	5	discussion	discussion	NOUN
admet-2334	58	6	,	,	PUNCT
admet-2334	58	7	chameleonicity	chameleonicity	NOUN
admet-2334	58	8	deserves	deserve	VERB
admet-2334	58	9	to	to	PART
admet-2334	58	10	be	be	AUX
admet-2334	58	11	included	include	VERB
admet-2334	58	12	in	in	ADP
admet-2334	58	13	the	the	DET
admet-2334	58	14	pool	pool	NOUN
admet-2334	58	15	of	of	ADP
admet-2334	58	16	investigated	investigate	VERB
admet-2334	58	17	physicochemical	physicochemical	ADJ
admet-2334	58	18	properties	property	NOUN
admet-2334	58	19	to	to	PART
admet-2334	58	20	predict	predict	VERB
admet-2334	58	21	in	in	ADP
admet-2334	58	22	vitro	vitro	X
admet-2334	58	23	adme	adme	NOUN
admet-2334	58	24	properties	property	NOUN
admet-2334	58	25	and	and	CCONJ
admet-2334	58	26	bioavailability	bioavailability	NOUN
admet-2334	58	27	(	(	PUNCT
admet-2334	58	28	figure	figure	NOUN
admet-2334	58	29	2	2	NUM
admet-2334	58	30	)	)	PUNCT
admet-2334	58	31	.	.	PUNCT
admet-2334	59	1	figure	figure	NOUN
admet-2334	59	2	2	2	NUM
admet-2334	59	3	.	.	PUNCT
admet-2334	60	1	the	the	DET
admet-2334	60	2	bro5	bro5	PROPN
admet-2334	60	3	chemical	chemical	NOUN
admet-2334	60	4	space	space	NOUN
admet-2334	60	5	oral	oral	ADJ
admet-2334	60	6	bioavailability	bioavailability	NOUN
admet-2334	60	7	determinants	determinant	NOUN
admet-2334	60	8	:	:	PUNCT
admet-2334	60	9	molecular	molecular	ADJ
admet-2334	60	10	and	and	CCONJ
admet-2334	60	11	in	in	ADP
admet-2334	60	12	vitro	vitro	X
admet-2334	60	13	adme	adme	NOUN
admet-2334	60	14	properties	property	NOUN
admet-2334	60	15	.	.	PUNCT
admet-2334	61	1	the	the	DET
admet-2334	61	2	pool	pool	NOUN
admet-2334	61	3	of	of	ADP
admet-2334	61	4	physicochemical	physicochemical	ADJ
admet-2334	61	5	descriptors	descriptor	NOUN
admet-2334	61	6	suitable	suitable	ADJ
admet-2334	61	7	for	for	ADP
admet-2334	61	8	the	the	DET
admet-2334	61	9	bro5	bro5	NOUN
admet-2334	61	10	space	space	NOUN
admet-2334	61	11	physicochemical	physicochemical	ADJ
admet-2334	61	12	descriptors	descriptor	NOUN
admet-2334	61	13	numerically	numerically	ADV
admet-2334	61	14	quantify	quantify	VERB
admet-2334	61	15	molecular	molecular	ADJ
admet-2334	61	16	properties	property	NOUN
admet-2334	61	17	.	.	PUNCT
admet-2334	62	1	figure	figure	VERB
admet-2334	62	2	3	3	NUM
admet-2334	62	3	summarizes	summarize	NOUN
admet-2334	62	4	the	the	DET
admet-2334	62	5	physicochemical	physicochemical	ADJ
admet-2334	62	6	descriptors	descriptor	NOUN
admet-2334	62	7	,	,	PUNCT
admet-2334	62	8	mostly	mostly	ADV
admet-2334	62	9	experimental	experimental	ADJ
admet-2334	62	10	,	,	PUNCT
admet-2334	62	11	implemented	implement	VERB
admet-2334	62	12	in	in	ADP
admet-2334	62	13	our	our	PRON
admet-2334	62	14	lab	lab	NOUN
admet-2334	62	15	to	to	PART
admet-2334	62	16	quantify	quantify	VERB
admet-2334	62	17	ionization	ionization	NOUN
admet-2334	62	18	,	,	PUNCT
admet-2334	62	19	size	size	NOUN
admet-2334	62	20	and	and	CCONJ
admet-2334	62	21	shape	shape	NOUN
admet-2334	62	22	,	,	PUNCT
admet-2334	62	23	lipophilicity	lipophilicity	NOUN
admet-2334	62	24	,	,	PUNCT
admet-2334	62	25	polarity	polarity	NOUN
admet-2334	62	26	and	and	CCONJ
admet-2334	62	27	chameleonicity	chameleonicity	NOUN
admet-2334	62	28	.	.	PUNCT
admet-2334	63	1	figure	figure	VERB
admet-2334	63	2	3	3	NUM
admet-2334	63	3	.	.	PUNCT
admet-2334	64	1	molecular	molecular	ADJ
admet-2334	64	2	properties	property	NOUN
admet-2334	64	3	and	and	CCONJ
admet-2334	64	4	related	related	ADJ
admet-2334	64	5	descriptors	descriptor	NOUN
admet-2334	64	6	to	to	PART
admet-2334	64	7	be	be	AUX
admet-2334	64	8	applied	apply	VERB
admet-2334	64	9	in	in	ADP
admet-2334	64	10	the	the	DET
admet-2334	64	11	bro5	bro5	NOUN
admet-2334	64	12	space	space	NOUN
admet-2334	64	13	.	.	PUNCT
admet-2334	65	1	ionization	ionization	NOUN
admet-2334	65	2	lipophilicity	lipophilicity	NOUN
admet-2334	65	3	polaritysize	polaritysize	NOUN
admet-2334	65	4	and	and	CCONJ
admet-2334	65	5	shape	shape	VERB
admet-2334	65	6	chameleonicity	chameleonicity	NOUN
admet-2334	65	7	ionization	ionization	NOUN
admet-2334	65	8	•	•	ADP
admet-2334	65	9	pka	pka	PROPN
admet-2334	65	10	in	in	ADP
admet-2334	65	11	water	water	NOUN
admet-2334	65	12	•	•	X
admet-2334	65	13	pka	pka	PROPN
admet-2334	65	14	in	in	ADP
admet-2334	65	15	nonpolar	nonpolar	ADJ
admet-2334	65	16	media	medium	NOUN
admet-2334	65	17	•	•	ADP
admet-2334	65	18	mw	mw	NOUN
admet-2334	65	19	•	•	PROPN
admet-2334	65	20	rgyr	rgyr	NOUN
admet-2334	65	21	lipophilicity	lipophilicity	NOUN
admet-2334	65	22	•	•	NOUN
admet-2334	65	23	brlogd	brlogd	NOUN
admet-2334	65	24	•	•	NOUN
admet-2334	65	25	log	log	NOUN
admet-2334	65	26	kw	kw	PROPN
admet-2334	65	27	iam	iam	PROPN
admet-2334	65	28	•	•	ADJ
admet-2334	65	29	log	log	NOUN
admet-2334	65	30	k’80	k’80	PUNCT
admet-2334	66	1	plrp	plrp	NOUN
admet-2334	66	2	-	-	PUNCT
admet-2334	66	3	s	s	NOUN
admet-2334	66	4	polarity	polarity	NOUN
admet-2334	66	5	•	•	NOUN
admet-2334	66	6	δ	δ	PROPN
admet-2334	66	7	log	log	VERB
admet-2334	66	8	poct	poct	PROPN
admet-2334	66	9	-	-	PUNCT
admet-2334	66	10	dod	dod	PROPN
admet-2334	66	11	•	•	NUM
admet-2334	66	12	epsa	epsa	NOUN
admet-2334	66	13	•	•	NUM
admet-2334	67	1	δ	δ	NOUN
admet-2334	67	2	log	log	VERB
admet-2334	67	3	kw	kw	PROPN
admet-2334	67	4	iam	iam	PROPN
admet-2334	67	5	•	•	PROPN
admet-2334	67	6	3d	3d	PROPN
admet-2334	67	7	psa	psa	VERB
admet-2334	67	8	chamaleonicity	chamaleonicity	NOUN
admet-2334	67	9	•	•	ADP
admet-2334	67	10	chamelogd	chamelogd	NOUN
admet-2334	67	11	•	•	ADP
admet-2334	67	12	chamelogk	chamelogk	ADJ
admet-2334	67	13	size	size	NOUN
admet-2334	67	14	and	and	CCONJ
admet-2334	67	15	shape	shape	NOUN
admet-2334	67	16	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	68	1	d.	d.	PROPN
admet-2334	68	2	g.	g.	PROPN
admet-2334	68	3	jiménez	jiménez	PROPN
admet-2334	68	4	et	et	PROPN
admet-2334	68	5	al	al	PROPN
admet-2334	68	6	.	.	PROPN
admet-2334	68	7	admet	admet	PROPN
admet-2334	68	8	&	&	CCONJ
admet-2334	68	9	dmpk	dmpk	PROPN
admet-2334	68	10	12(5	12(5	NUM
admet-2334	68	11	)	)	PUNCT
admet-2334	68	12	(	(	PUNCT
admet-2334	68	13	2024	2024	NUM
admet-2334	68	14	)	)	PUNCT
admet-2334	68	15	721	721	NUM
admet-2334	68	16	-	-	SYM
admet-2334	68	17	736	736	NUM
admet-2334	68	18	724	724	NUM
admet-2334	68	19	ionization	ionization	NOUN
admet-2334	68	20	the	the	DET
admet-2334	68	21	ionization	ionization	NOUN
admet-2334	68	22	constant	constant	ADJ
admet-2334	68	23	(	(	PUNCT
admet-2334	68	24	usually	usually	ADV
admet-2334	68	25	reported	report	VERB
admet-2334	68	26	as	as	ADP
admet-2334	68	27	pka	pka	PROPN
admet-2334	68	28	)	)	PUNCT
admet-2334	68	29	is	be	AUX
admet-2334	68	30	an	an	DET
admet-2334	68	31	important	important	ADJ
admet-2334	68	32	parameter	parameter	NOUN
admet-2334	68	33	for	for	ADP
admet-2334	68	34	evaluating	evaluate	VERB
admet-2334	68	35	ionizable	ionizable	ADJ
admet-2334	68	36	molecules	molecule	NOUN
admet-2334	68	37	since	since	SCONJ
admet-2334	68	38	it	it	PRON
admet-2334	68	39	may	may	AUX
admet-2334	68	40	have	have	VERB
admet-2334	68	41	a	a	DET
admet-2334	68	42	decisive	decisive	ADJ
admet-2334	68	43	impact	impact	NOUN
admet-2334	68	44	on	on	ADP
admet-2334	68	45	the	the	DET
admet-2334	68	46	in	in	X
admet-2334	68	47	vitro	vitro	X
admet-2334	68	48	adme	adme	NOUN
admet-2334	68	49	properties	property	NOUN
admet-2334	68	50	.	.	PUNCT
admet-2334	69	1	for	for	ADP
admet-2334	69	2	instance	instance	NOUN
admet-2334	69	3	,	,	PUNCT
admet-2334	69	4	an	an	DET
admet-2334	69	5	ionized	ionized	ADJ
admet-2334	69	6	species	species	NOUN
admet-2334	69	7	is	be	AUX
admet-2334	69	8	more	more	ADJ
admet-2334	69	9	water	water	NOUN
admet-2334	69	10	soluble	soluble	ADJ
admet-2334	69	11	but	but	CCONJ
admet-2334	69	12	has	have	VERB
admet-2334	69	13	a	a	DET
admet-2334	69	14	lower	low	ADJ
admet-2334	69	15	cell	cell	NOUN
admet-2334	69	16	permeability	permeability	NOUN
admet-2334	69	17	than	than	ADP
admet-2334	69	18	the	the	DET
admet-2334	69	19	neutral	neutral	ADJ
admet-2334	69	20	form	form	NOUN
admet-2334	69	21	.	.	PUNCT
admet-2334	70	1	pka	pka	NOUN
admet-2334	70	2	is	be	AUX
admet-2334	70	3	often	often	ADV
admet-2334	70	4	determined	determine	VERB
admet-2334	70	5	in	in	ADP
admet-2334	70	6	water	water	NOUN
admet-2334	70	7	,	,	PUNCT
admet-2334	70	8	but	but	CCONJ
admet-2334	70	9	pka	pka	PROPN
admet-2334	70	10	measurements	measurement	NOUN
admet-2334	70	11	in	in	ADP
admet-2334	70	12	different	different	ADJ
admet-2334	70	13	media	medium	NOUN
admet-2334	70	14	can	can	AUX
admet-2334	70	15	be	be	AUX
admet-2334	70	16	relevant	relevant	ADJ
admet-2334	70	17	since	since	SCONJ
admet-2334	70	18	pka	pka	PROPN
admet-2334	70	19	varies	vary	VERB
admet-2334	70	20	with	with	ADP
admet-2334	70	21	the	the	DET
admet-2334	70	22	media	medium	NOUN
admet-2334	70	23	,	,	PUNCT
admet-2334	70	24	and	and	CCONJ
admet-2334	70	25	thus	thus	ADV
admet-2334	70	26	,	,	PUNCT
admet-2334	70	27	a	a	DET
admet-2334	70	28	compound	compound	NOUN
admet-2334	70	29	may	may	AUX
admet-2334	70	30	be	be	AUX
admet-2334	70	31	mostly	mostly	ADV
admet-2334	70	32	ionized	ionize	VERB
admet-2334	70	33	in	in	ADP
admet-2334	70	34	water	water	NOUN
admet-2334	70	35	and	and	CCONJ
admet-2334	70	36	not	not	PART
admet-2334	70	37	ionized	ionize	VERB
admet-2334	70	38	in	in	ADP
admet-2334	70	39	the	the	DET
admet-2334	70	40	interior	interior	ADJ
admet-2334	70	41	regions	region	NOUN
admet-2334	70	42	of	of	ADP
admet-2334	70	43	membranes	membrane	NOUN
admet-2334	70	44	.	.	PUNCT
admet-2334	71	1	recent	recent	ADJ
admet-2334	71	2	studies	study	NOUN
admet-2334	71	3	revealed	reveal	VERB
admet-2334	71	4	that	that	SCONJ
admet-2334	71	5	ionization	ionization	NOUN
admet-2334	71	6	decreases	decrease	VERB
admet-2334	71	7	for	for	ADP
admet-2334	71	8	both	both	CCONJ
admet-2334	71	9	acids	acid	NOUN
admet-2334	71	10	and	and	CCONJ
admet-2334	71	11	bases	basis	NOUN
admet-2334	71	12	in	in	ADP
admet-2334	71	13	a	a	DET
admet-2334	71	14	coherent	coherent	ADJ
admet-2334	71	15	,	,	PUNCT
admet-2334	71	16	significant	significant	ADJ
admet-2334	71	17	but	but	CCONJ
admet-2334	71	18	not	not	PART
admet-2334	71	19	dramatical	dramatical	ADJ
admet-2334	71	20	extent	extent	NOUN
admet-2334	71	21	when	when	SCONJ
admet-2334	71	22	some	some	DET
admet-2334	71	23	amount	amount	NOUN
admet-2334	71	24	of	of	ADP
admet-2334	71	25	an	an	DET
admet-2334	71	26	organic	organic	ADJ
admet-2334	71	27	solvent	solvent	NOUN
admet-2334	71	28	(	(	PUNCT
admet-2334	71	29	e.g.	e.g.	ADV
admet-2334	71	30	acetonitrile	acetonitrile	NOUN
admet-2334	71	31	)	)	PUNCT
admet-2334	71	32	is	be	AUX
admet-2334	71	33	present	present	ADJ
admet-2334	71	34	in	in	ADP
admet-2334	71	35	the	the	DET
admet-2334	71	36	environment	environment	NOUN
admet-2334	71	37	,	,	PUNCT
admet-2334	71	38	but	but	CCONJ
admet-2334	71	39	the	the	DET
admet-2334	71	40	picture	picture	NOUN
admet-2334	71	41	is	be	AUX
admet-2334	71	42	completely	completely	ADV
admet-2334	71	43	different	different	ADJ
admet-2334	71	44	in	in	ADP
admet-2334	71	45	pure	pure	ADJ
admet-2334	71	46	acetonitrile	acetonitrile	NOUN
admet-2334	71	47	(	(	PUNCT
admet-2334	71	48	mecn	mecn	PROPN
admet-2334	71	49	)	)	PUNCT
admet-2334	72	1	[	[	X
admet-2334	72	2	14	14	NUM
admet-2334	72	3	]	]	PUNCT
admet-2334	72	4	.	.	PUNCT
admet-2334	73	1	since	since	SCONJ
admet-2334	73	2	the	the	DET
admet-2334	73	3	experimental	experimental	ADJ
admet-2334	73	4	determination	determination	NOUN
admet-2334	73	5	of	of	ADP
admet-2334	73	6	pka	pka	PROPN
admet-2334	73	7	is	be	AUX
admet-2334	73	8	not	not	PART
admet-2334	73	9	a	a	DET
admet-2334	73	10	trivial	trivial	ADJ
admet-2334	73	11	assay	assay	NOUN
admet-2334	73	12	and	and	CCONJ
admet-2334	73	13	a	a	DET
admet-2334	73	14	certain	certain	ADJ
admet-2334	73	15	degree	degree	NOUN
admet-2334	73	16	of	of	ADP
admet-2334	73	17	expertise	expertise	NOUN
admet-2334	73	18	is	be	AUX
admet-2334	73	19	required	require	VERB
admet-2334	73	20	,	,	PUNCT
admet-2334	73	21	caron	caron	PROPN
admet-2334	73	22	’s	’s	PROPN
admet-2334	73	23	group	group	NOUN
admet-2334	73	24	observed	observe	VERB
admet-2334	73	25	that	that	SCONJ
admet-2334	73	26	the	the	DET
admet-2334	73	27	ionization	ionization	NOUN
admet-2334	73	28	behaviour	behaviour	NOUN
admet-2334	73	29	(	(	PUNCT
admet-2334	73	30	not	not	PART
admet-2334	73	31	the	the	DET
admet-2334	73	32	pka	pka	NOUN
admet-2334	73	33	)	)	PUNCT
admet-2334	73	34	of	of	ADP
admet-2334	73	35	a	a	DET
admet-2334	73	36	molecule	molecule	NOUN
admet-2334	73	37	can	can	AUX
admet-2334	73	38	be	be	AUX
admet-2334	73	39	obtained	obtain	VERB
admet-2334	73	40	by	by	ADP
admet-2334	73	41	monitoring	monitor	VERB
admet-2334	73	42	the	the	DET
admet-2334	73	43	variation	variation	NOUN
admet-2334	73	44	of	of	ADP
admet-2334	73	45	the	the	DET
admet-2334	73	46	log	log	NOUN
admet-2334	73	47	of	of	ADP
admet-2334	73	48	the	the	DET
admet-2334	73	49	capacity	capacity	NOUN
admet-2334	73	50	factor	factor	NOUN
admet-2334	73	51	in	in	ADP
admet-2334	73	52	the	the	DET
admet-2334	73	53	plrp	plrp	NOUN
admet-2334	73	54	-	-	PUNCT
admet-2334	73	55	s	s	NOUN
admet-2334	73	56	system	system	NOUN
admet-2334	73	57	(	(	PUNCT
admet-2334	73	58	log	log	PROPN
admet-2334	73	59	k'80	k'80	PROPN
admet-2334	73	60	plrp	plrp	NOUN
admet-2334	73	61	-	-	PUNCT
admet-2334	73	62	s	s	NOUN
admet-2334	73	63	)	)	PUNCT
admet-2334	73	64	vs.	vs.	ADP
admet-2334	73	65	the	the	DET
admet-2334	73	66	ph	ph	NOUN
admet-2334	74	1	[	[	X
admet-2334	74	2	15	15	NUM
admet-2334	74	3	]	]	PUNCT
admet-2334	74	4	.	.	PUNCT
admet-2334	75	1	in	in	ADP
admet-2334	75	2	practice	practice	NOUN
admet-2334	75	3	,	,	PUNCT
admet-2334	75	4	this	this	DET
admet-2334	75	5	variation	variation	NOUN
admet-2334	75	6	reveals	reveal	VERB
admet-2334	75	7	the	the	DET
admet-2334	75	8	acidic	acidic	ADJ
admet-2334	75	9	,	,	PUNCT
admet-2334	75	10	neutral	neutral	ADJ
admet-2334	75	11	or	or	CCONJ
admet-2334	75	12	basic	basic	ADJ
admet-2334	75	13	nature	nature	NOUN
admet-2334	75	14	of	of	ADP
admet-2334	75	15	the	the	DET
admet-2334	75	16	investigated	investigate	VERB
admet-2334	75	17	compound	compound	NOUN
admet-2334	75	18	.	.	PUNCT
admet-2334	76	1	while	while	SCONJ
admet-2334	76	2	measuring	measure	VERB
admet-2334	76	3	pka	pka	PROPN
admet-2334	76	4	using	use	VERB
admet-2334	76	5	standard	standard	ADJ
admet-2334	76	6	methods	method	NOUN
admet-2334	76	7	is	be	AUX
admet-2334	76	8	generally	generally	ADV
admet-2334	76	9	preferable	preferable	ADJ
admet-2334	76	10	,	,	PUNCT
admet-2334	76	11	this	this	DET
admet-2334	76	12	estimation	estimation	NOUN
admet-2334	76	13	can	can	AUX
admet-2334	76	14	serve	serve	VERB
admet-2334	76	15	as	as	ADP
admet-2334	76	16	a	a	DET
admet-2334	76	17	satisfactory	satisfactory	ADJ
admet-2334	76	18	alternative	alternative	NOUN
admet-2334	76	19	in	in	ADP
admet-2334	76	20	many	many	ADJ
admet-2334	76	21	instances	instance	NOUN
admet-2334	76	22	,	,	PUNCT
admet-2334	76	23	especially	especially	ADV
admet-2334	76	24	for	for	ADP
admet-2334	76	25	compounds	compound	NOUN
admet-2334	76	26	like	like	ADP
admet-2334	76	27	bro5	bro5	NOUN
admet-2334	76	28	molecules	molecule	NOUN
admet-2334	76	29	that	that	PRON
admet-2334	76	30	face	face	VERB
admet-2334	76	31	solubility	solubility	NOUN
admet-2334	76	32	limitations	limitation	NOUN
admet-2334	76	33	.	.	PUNCT
admet-2334	77	1	interestingly	interestingly	ADV
admet-2334	77	2	,	,	PUNCT
admet-2334	77	3	and	and	CCONJ
admet-2334	77	4	in	in	ADP
admet-2334	77	5	line	line	NOUN
admet-2334	77	6	with	with	ADP
admet-2334	77	7	existing	exist	VERB
admet-2334	77	8	literature	literature	NOUN
admet-2334	77	9	,	,	PUNCT
admet-2334	77	10	the	the	DET
admet-2334	77	11	ionization	ionization	NOUN
admet-2334	77	12	behaviour	behaviour	NOUN
admet-2334	77	13	of	of	ADP
admet-2334	77	14	bro5	bro5	NOUN
admet-2334	77	15	molecules	molecule	NOUN
admet-2334	77	16	is	be	AUX
admet-2334	77	17	rarely	rarely	ADV
admet-2334	77	18	experimentally	experimentally	ADV
admet-2334	77	19	determined	determine	VERB
admet-2334	77	20	.	.	PUNCT
admet-2334	78	1	in	in	ADP
admet-2334	78	2	many	many	ADJ
admet-2334	78	3	cases	case	NOUN
admet-2334	78	4	,	,	PUNCT
admet-2334	78	5	ionization	ionization	NOUN
admet-2334	78	6	is	be	AUX
admet-2334	78	7	completely	completely	ADV
admet-2334	78	8	overlooked	overlook	VERB
admet-2334	78	9	,	,	PUNCT
admet-2334	78	10	and	and	CCONJ
admet-2334	78	11	in	in	ADP
admet-2334	78	12	some	some	DET
admet-2334	78	13	instances	instance	NOUN
admet-2334	78	14	,	,	PUNCT
admet-2334	78	15	it	it	PRON
admet-2334	78	16	is	be	AUX
admet-2334	78	17	predicted	predict	VERB
admet-2334	78	18	using	use	VERB
admet-2334	78	19	standard	standard	ADJ
admet-2334	78	20	calculators	calculator	NOUN
admet-2334	78	21	not	not	PART
admet-2334	78	22	designed	design	VERB
admet-2334	78	23	for	for	ADP
admet-2334	78	24	large	large	ADJ
admet-2334	78	25	,	,	PUNCT
admet-2334	78	26	flexible	flexible	ADJ
admet-2334	78	27	molecules	molecule	NOUN
admet-2334	78	28	.	.	PUNCT
admet-2334	79	1	size	size	NOUN
admet-2334	79	2	and	and	CCONJ
admet-2334	79	3	shape	shape	NOUN
admet-2334	79	4	as	as	ADP
admet-2334	79	5	previously	previously	ADV
admet-2334	79	6	mentioned	mention	VERB
admet-2334	79	7	,	,	PUNCT
admet-2334	79	8	bro5	bro5	NOUN
admet-2334	79	9	compounds	compound	NOUN
admet-2334	79	10	are	be	AUX
admet-2334	79	11	known	know	VERB
admet-2334	79	12	for	for	ADP
admet-2334	79	13	their	their	PRON
admet-2334	79	14	large	large	ADJ
admet-2334	79	15	size	size	NOUN
admet-2334	79	16	(	(	PUNCT
admet-2334	79	17	mw	mw	X
admet-2334	79	18	˃	˃	PROPN
admet-2334	79	19	500	500	NUM
admet-2334	79	20	da	da	NOUN
admet-2334	79	21	)	)	PUNCT
admet-2334	79	22	,	,	PUNCT
admet-2334	79	23	which	which	PRON
admet-2334	79	24	can	can	AUX
admet-2334	79	25	confer	confer	VERB
admet-2334	79	26	poor	poor	ADJ
admet-2334	79	27	solubility	solubility	NOUN
admet-2334	79	28	and/or	and/or	CCONJ
admet-2334	79	29	permeability	permeability	NOUN
admet-2334	79	30	across	across	ADP
admet-2334	79	31	the	the	DET
admet-2334	79	32	membrane	membrane	NOUN
admet-2334	79	33	[	[	X
admet-2334	79	34	16	16	NUM
admet-2334	79	35	]	]	PUNCT
admet-2334	79	36	.	.	PUNCT
admet-2334	80	1	similarly	similarly	ADV
admet-2334	80	2	,	,	PUNCT
admet-2334	80	3	the	the	DET
admet-2334	80	4	efflux	efflux	NOUN
admet-2334	80	5	pump	pump	NOUN
admet-2334	80	6	(	(	PUNCT
admet-2334	80	7	such	such	ADJ
admet-2334	80	8	as	as	ADP
admet-2334	80	9	pgp	pgp	NOUN
admet-2334	80	10	)	)	PUNCT
admet-2334	80	11	,	,	PUNCT
admet-2334	80	12	which	which	PRON
admet-2334	80	13	expels	expel	VERB
admet-2334	80	14	drugs	drug	NOUN
admet-2334	80	15	from	from	ADP
admet-2334	80	16	cells	cell	NOUN
admet-2334	80	17	,	,	PUNCT
admet-2334	80	18	is	be	AUX
admet-2334	80	19	activated	activate	VERB
admet-2334	80	20	by	by	ADP
admet-2334	80	21	molecules	molecule	NOUN
admet-2334	80	22	with	with	ADP
admet-2334	80	23	high	high	ADJ
admet-2334	80	24	molecular	molecular	ADJ
admet-2334	80	25	weight	weight	NOUN
admet-2334	80	26	.	.	PUNCT
admet-2334	81	1	additionally	additionally	ADV
admet-2334	81	2	,	,	PUNCT
admet-2334	81	3	the	the	DET
admet-2334	81	4	stokes	stokes	PROPN
admet-2334	81	5	-	-	PUNCT
admet-2334	81	6	einstein	einstein	NOUN
admet-2334	81	7	equation	equation	NOUN
admet-2334	81	8	suggests	suggest	VERB
admet-2334	81	9	that	that	SCONJ
admet-2334	81	10	the	the	DET
admet-2334	81	11	shape	shape	NOUN
admet-2334	81	12	of	of	ADP
admet-2334	81	13	the	the	DET
admet-2334	81	14	molecule	molecule	NOUN
admet-2334	81	15	,	,	PUNCT
admet-2334	81	16	indicated	indicate	VERB
admet-2334	81	17	by	by	ADP
admet-2334	81	18	the	the	DET
admet-2334	81	19	hydrodynamic	hydrodynamic	ADJ
admet-2334	81	20	radius	radius	NOUN
admet-2334	81	21	,	,	PUNCT
admet-2334	81	22	affects	affect	VERB
admet-2334	81	23	the	the	DET
admet-2334	81	24	passive	passive	ADJ
admet-2334	81	25	diffusion	diffusion	NOUN
admet-2334	81	26	coefficient	coefficient	NOUN
admet-2334	81	27	[	[	X
admet-2334	81	28	17	17	NUM
admet-2334	81	29	]	]	PUNCT
admet-2334	81	30	.	.	PUNCT
admet-2334	82	1	however	however	ADV
admet-2334	82	2	,	,	PUNCT
admet-2334	82	3	the	the	DET
admet-2334	82	4	influence	influence	NOUN
admet-2334	82	5	of	of	ADP
admet-2334	82	6	the	the	DET
admet-2334	82	7	shape	shape	NOUN
admet-2334	82	8	on	on	ADP
admet-2334	82	9	molecular	molecular	ADJ
admet-2334	82	10	properties	property	NOUN
admet-2334	82	11	and	and	CCONJ
admet-2334	82	12	,	,	PUNCT
admet-2334	82	13	thus	thus	ADV
admet-2334	82	14	,	,	PUNCT
admet-2334	82	15	on	on	ADV
admet-2334	82	16	in	in	ADP
admet-2334	82	17	vitro	vitro	X
admet-2334	82	18	assays	assay	NOUN
admet-2334	82	19	is	be	AUX
admet-2334	82	20	not	not	PART
admet-2334	82	21	experimentally	experimentally	ADV
admet-2334	82	22	clear	clear	ADJ
admet-2334	82	23	.	.	PUNCT
admet-2334	83	1	there	there	PRON
admet-2334	83	2	is	be	VERB
admet-2334	83	3	,	,	PUNCT
admet-2334	83	4	therefore	therefore	ADV
admet-2334	83	5	,	,	PUNCT
admet-2334	83	6	a	a	DET
admet-2334	83	7	clear	clear	ADJ
admet-2334	83	8	need	need	NOUN
admet-2334	83	9	to	to	PART
admet-2334	83	10	computationally	computationally	ADV
admet-2334	83	11	quantify	quantify	VERB
admet-2334	83	12	these	these	DET
admet-2334	83	13	two	two	NUM
admet-2334	83	14	properties	property	NOUN
admet-2334	83	15	.	.	PUNCT
admet-2334	84	1	mw	mw	PROPN
admet-2334	84	2	is	be	AUX
admet-2334	84	3	the	the	DET
admet-2334	84	4	default	default	NOUN
admet-2334	84	5	1d	1d	NUM
admet-2334	84	6	descriptor	descriptor	NOUN
admet-2334	84	7	of	of	ADP
admet-2334	84	8	molecular	molecular	ADJ
admet-2334	84	9	size	size	NOUN
admet-2334	84	10	,	,	PUNCT
admet-2334	84	11	while	while	SCONJ
admet-2334	84	12	the	the	DET
admet-2334	84	13	radius	radius	NOUN
admet-2334	84	14	of	of	ADP
admet-2334	84	15	gyration	gyration	ADJ
admet-2334	84	16	rgyr	rgyr	NOUN
admet-2334	84	17	describes	describe	VERB
admet-2334	84	18	the	the	DET
admet-2334	84	19	3d	3d	NUM
admet-2334	84	20	shape	shape	NOUN
admet-2334	84	21	of	of	ADP
admet-2334	84	22	the	the	DET
admet-2334	84	23	molecular	molecular	ADJ
admet-2334	84	24	conformers	conformer	NOUN
admet-2334	84	25	;	;	PUNCT
admet-2334	84	26	the	the	PRON
admet-2334	84	27	lower	low	ADJ
admet-2334	84	28	the	the	DET
admet-2334	84	29	rgyr	rgyr	NOUN
admet-2334	84	30	,	,	PUNCT
admet-2334	84	31	the	the	PRON
admet-2334	84	32	higher	high	ADJ
admet-2334	84	33	the	the	DET
admet-2334	84	34	molecular	molecular	ADJ
admet-2334	84	35	sphericity	sphericity	NOUN
admet-2334	84	36	.	.	PUNCT
admet-2334	85	1	rgyr	rgyr	PROPN
admet-2334	85	2	is	be	AUX
admet-2334	85	3	calculated	calculate	VERB
admet-2334	85	4	as	as	ADP
admet-2334	85	5	the	the	DET
admet-2334	85	6	root	root	NOUN
admet-2334	85	7	-	-	PUNCT
admet-2334	85	8	mean	mean	ADJ
admet-2334	85	9	-	-	PUNCT
admet-2334	85	10	square	square	NOUN
admet-2334	85	11	distance	distance	NOUN
admet-2334	85	12	(	(	PUNCT
admet-2334	85	13	rmsd	rmsd	NOUN
admet-2334	85	14	)	)	PUNCT
admet-2334	85	15	of	of	ADP
admet-2334	85	16	each	each	DET
admet-2334	85	17	atom	atom	NOUN
admet-2334	85	18	in	in	ADP
admet-2334	85	19	the	the	DET
admet-2334	85	20	molecule	molecule	NOUN
admet-2334	85	21	from	from	ADP
admet-2334	85	22	the	the	DET
admet-2334	85	23	center	center	NOUN
admet-2334	85	24	of	of	ADP
admet-2334	85	25	mass	mass	NOUN
admet-2334	85	26	using	use	VERB
admet-2334	85	27	various	various	ADJ
admet-2334	85	28	software	software	NOUN
admet-2334	85	29	programs	program	NOUN
admet-2334	85	30	[	[	X
admet-2334	85	31	18	18	NUM
admet-2334	85	32	]	]	PUNCT
admet-2334	85	33	.	.	PUNCT
admet-2334	86	1	lipophilicity	lipophilicity	PROPN
admet-2334	86	2	lipophilicity	lipophilicity	NOUN
admet-2334	86	3	is	be	AUX
admet-2334	86	4	formally	formally	ADV
admet-2334	86	5	defined	define	VERB
admet-2334	86	6	by	by	ADP
admet-2334	86	7	the	the	DET
admet-2334	86	8	iupac	iupac	PROPN
admet-2334	86	9	as	as	ADP
admet-2334	86	10	the	the	DET
admet-2334	86	11	affinity	affinity	NOUN
admet-2334	86	12	of	of	ADP
admet-2334	86	13	a	a	DET
admet-2334	86	14	molecule	molecule	NOUN
admet-2334	86	15	for	for	ADP
admet-2334	86	16	a	a	DET
admet-2334	86	17	lipophilic	lipophilic	ADJ
admet-2334	86	18	environment	environment	NOUN
admet-2334	86	19	.	.	PUNCT
admet-2334	87	1	testa	testa	PROPN
admet-2334	87	2	and	and	CCONJ
admet-2334	87	3	coworkers	coworker	NOUN
admet-2334	87	4	deconvoluted	deconvolute	VERB
admet-2334	87	5	lipophilicity	lipophilicity	NOUN
admet-2334	87	6	into	into	ADP
admet-2334	87	7	a	a	DET
admet-2334	87	8	positive	positive	ADJ
admet-2334	87	9	contribution	contribution	NOUN
admet-2334	87	10	of	of	ADP
admet-2334	87	11	hydrophobicity	hydrophobicity	NOUN
admet-2334	87	12	(	(	PUNCT
admet-2334	87	13	water	water	NOUN
admet-2334	87	14	repulsion	repulsion	NOUN
admet-2334	87	15	)	)	PUNCT
admet-2334	87	16	and	and	CCONJ
admet-2334	87	17	a	a	DET
admet-2334	87	18	negative	negative	ADJ
admet-2334	87	19	contribution	contribution	NOUN
admet-2334	87	20	of	of	ADP
admet-2334	87	21	polarity	polarity	NOUN
admet-2334	87	22	(	(	PUNCT
admet-2334	87	23	separation	separation	NOUN
admet-2334	87	24	of	of	ADP
admet-2334	87	25	electronic	electronic	ADJ
admet-2334	87	26	charges	charge	NOUN
admet-2334	87	27	)	)	PUNCT
admet-2334	88	1	[	[	X
admet-2334	88	2	19	19	NUM
admet-2334	88	3	]	]	PUNCT
admet-2334	88	4	.	.	PUNCT
admet-2334	89	1	thus	thus	ADV
admet-2334	89	2	,	,	PUNCT
admet-2334	89	3	hydrophobic	hydrophobic	NOUN
admet-2334	89	4	effects	effect	NOUN
admet-2334	89	5	(	(	PUNCT
admet-2334	89	6	hydrophobic	hydrophobic	NOUN
admet-2334	89	7	and	and	CCONJ
admet-2334	89	8	steric	steric	ADJ
admet-2334	89	9	interactions	interaction	NOUN
admet-2334	89	10	,	,	PUNCT
admet-2334	89	11	hydrophobic	hydrophobic	NOUN
admet-2334	89	12	collapse	collapse	NOUN
admet-2334	89	13	,	,	PUNCT
admet-2334	89	14	polar	polar	ADJ
admet-2334	89	15	group	group	NOUN
admet-2334	89	16	shielding	shielding	NOUN
admet-2334	89	17	,	,	PUNCT
admet-2334	89	18	etc	etc	X
admet-2334	89	19	.	.	X
admet-2334	89	20	)	)	PUNCT
admet-2334	89	21	increase	increase	VERB
admet-2334	89	22	the	the	DET
admet-2334	89	23	lipophilicity	lipophilicity	NOUN
admet-2334	89	24	of	of	ADP
admet-2334	89	25	a	a	DET
admet-2334	89	26	molecule	molecule	NOUN
admet-2334	89	27	,	,	PUNCT
admet-2334	89	28	whereas	whereas	SCONJ
admet-2334	89	29	the	the	DET
admet-2334	89	30	opposite	opposite	NOUN
admet-2334	89	31	is	be	AUX
admet-2334	89	32	true	true	ADJ
admet-2334	89	33	for	for	ADP
admet-2334	89	34	polarity	polarity	NOUN
admet-2334	89	35	.	.	PUNCT
admet-2334	90	1	this	this	PRON
admet-2334	90	2	implies	imply	VERB
admet-2334	90	3	that	that	SCONJ
admet-2334	90	4	lipophilicity	lipophilicity	NOUN
admet-2334	90	5	and	and	CCONJ
admet-2334	90	6	hydrophobicity	hydrophobicity	NOUN
admet-2334	90	7	are	be	AUX
admet-2334	90	8	not	not	PART
admet-2334	90	9	interchangeable	interchangeable	ADJ
admet-2334	90	10	terms	term	NOUN
admet-2334	90	11	and	and	CCONJ
admet-2334	90	12	that	that	SCONJ
admet-2334	90	13	polarity	polarity	NOUN
admet-2334	90	14	does	do	AUX
admet-2334	90	15	not	not	PART
admet-2334	90	16	stand	stand	VERB
admet-2334	90	17	in	in	ADP
admet-2334	90	18	opposition	opposition	NOUN
admet-2334	90	19	to	to	ADP
admet-2334	90	20	lipophilicity	lipophilicity	PROPN
admet-2334	90	21	.	.	PUNCT
admet-2334	91	1	the	the	DET
admet-2334	91	2	lipophilicity	lipophilicity	NOUN
admet-2334	91	3	of	of	ADP
admet-2334	91	4	a	a	DET
admet-2334	91	5	compound	compound	NOUN
admet-2334	91	6	is	be	AUX
admet-2334	91	7	expressed	express	VERB
admet-2334	91	8	as	as	ADP
admet-2334	91	9	log	log	NOUN
admet-2334	91	10	p	p	NOUN
admet-2334	91	11	for	for	ADP
admet-2334	91	12	neutral	neutral	ADJ
admet-2334	91	13	derivatives	derivative	NOUN
admet-2334	91	14	.	.	PUNCT
admet-2334	92	1	however	however	ADV
admet-2334	92	2	,	,	PUNCT
admet-2334	92	3	in	in	ADP
admet-2334	92	4	the	the	DET
admet-2334	92	5	case	case	NOUN
admet-2334	92	6	of	of	ADP
admet-2334	92	7	ionizable	ionizable	ADJ
admet-2334	92	8	centres	centre	NOUN
admet-2334	92	9	in	in	ADP
admet-2334	92	10	the	the	DET
admet-2334	92	11	molecule	molecule	NOUN
admet-2334	92	12	,	,	PUNCT
admet-2334	92	13	lipophilicity	lipophilicity	NOUN
admet-2334	92	14	is	be	AUX
admet-2334	92	15	expressed	express	VERB
admet-2334	92	16	as	as	ADP
admet-2334	92	17	log	log	NOUN
admet-2334	92	18	d	d	NOUN
admet-2334	92	19	at	at	ADP
admet-2334	92	20	a	a	DET
admet-2334	92	21	specific	specific	ADJ
admet-2334	92	22	ph	ph	NOUN
admet-2334	92	23	.	.	PROPN
admet-2334	92	24	besides	besides	SCONJ
admet-2334	92	25	the	the	DET
admet-2334	92	26	traditional	traditional	ADJ
admet-2334	92	27	shake	shake	NOUN
admet-2334	92	28	-	-	PUNCT
admet-2334	92	29	flask	flask	NOUN
admet-2334	92	30	method	method	NOUN
admet-2334	92	31	now	now	ADV
admet-2334	92	32	automated	automate	VERB
admet-2334	92	33	in	in	ADP
admet-2334	92	34	most	most	ADJ
admet-2334	92	35	contract	contract	NOUN
admet-2334	92	36	research	research	NOUN
admet-2334	92	37	organization	organization	NOUN
admet-2334	92	38	(	(	PUNCT
admet-2334	92	39	cro	cro	NOUN
admet-2334	92	40	)	)	PUNCT
admet-2334	92	41	protocols	protocol	NOUN
admet-2334	92	42	,	,	PUNCT
admet-2334	92	43	other	other	ADJ
admet-2334	92	44	methods	method	NOUN
admet-2334	92	45	for	for	ADP
admet-2334	92	46	measuring	measure	VERB
admet-2334	92	47	lipophilicity	lipophilicity	NOUN
admet-2334	92	48	,	,	PUNCT
admet-2334	92	49	such	such	ADJ
admet-2334	92	50	as	as	ADP
admet-2334	92	51	potentiometry	potentiometry	NOUN
admet-2334	92	52	or	or	CCONJ
admet-2334	92	53	high	high	ADJ
admet-2334	92	54	-	-	PUNCT
admet-2334	92	55	performance	performance	NOUN
admet-2334	92	56	liquid	liquid	ADJ
admet-2334	92	57	chromatographic	chromatographic	ADV
admet-2334	92	58	-	-	PUNCT
admet-2334	92	59	based	base	VERB
admet-2334	92	60	methods	method	NOUN
admet-2334	92	61	(	(	PUNCT
admet-2334	92	62	hplc	hplc	PROPN
admet-2334	92	63	)	)	PUNCT
admet-2334	92	64	,	,	PUNCT
admet-2334	92	65	have	have	AUX
admet-2334	92	66	been	be	AUX
admet-2334	92	67	reported	report	VERB
admet-2334	92	68	.	.	PUNCT
admet-2334	93	1	the	the	DET
admet-2334	93	2	potentiometric	potentiometric	ADJ
admet-2334	93	3	method	method	NOUN
admet-2334	93	4	is	be	AUX
admet-2334	93	5	based	base	VERB
admet-2334	93	6	on	on	ADP
admet-2334	93	7	the	the	DET
admet-2334	93	8	quantification	quantification	NOUN
admet-2334	93	9	of	of	ADP
admet-2334	93	10	the	the	DET
admet-2334	93	11	pka	pka	PROPN
admet-2334	93	12	change	change	NOUN
admet-2334	93	13	after	after	ADP
admet-2334	93	14	the	the	DET
admet-2334	93	15	addition	addition	NOUN
admet-2334	93	16	of	of	ADP
admet-2334	93	17	octanol	octanol	NOUN
admet-2334	93	18	to	to	ADP
admet-2334	93	19	an	an	DET
admet-2334	93	20	aqueous	aqueous	ADJ
admet-2334	93	21	solution	solution	NOUN
admet-2334	93	22	.	.	PUNCT
admet-2334	94	1	hplc	hplc	NOUN
admet-2334	94	2	-	-	PUNCT
admet-2334	94	3	based	base	VERB
admet-2334	94	4	methods	method	NOUN
admet-2334	94	5	have	have	AUX
admet-2334	94	6	gained	gain	VERB
admet-2334	94	7	popularity	popularity	NOUN
admet-2334	94	8	due	due	ADP
admet-2334	94	9	to	to	ADP
admet-2334	94	10	their	their	PRON
admet-2334	94	11	high	high	ADJ
admet-2334	94	12	degree	degree	NOUN
admet-2334	94	13	of	of	ADP
admet-2334	94	14	automation	automation	NOUN
admet-2334	94	15	and	and	CCONJ
admet-2334	94	16	their	their	PRON
admet-2334	94	17	ability	ability	NOUN
admet-2334	94	18	to	to	PART
admet-2334	94	19	deal	deal	VERB
admet-2334	94	20	with	with	ADP
admet-2334	94	21	impurities	impurity	NOUN
admet-2334	94	22	and	and	CCONJ
admet-2334	94	23	low	low	ADJ
admet-2334	94	24	concentrations	concentration	NOUN
admet-2334	94	25	.	.	PUNCT
admet-2334	95	1	in	in	ADP
admet-2334	95	2	admet	admet	PROPN
admet-2334	95	3	&	&	CCONJ
admet-2334	95	4	dmpk	dmpk	PROPN
admet-2334	95	5	12(5	12(5	NUM
admet-2334	95	6	)	)	PUNCT
admet-2334	95	7	(	(	PUNCT
admet-2334	95	8	2024	2024	NUM
admet-2334	95	9	)	)	PUNCT
admet-2334	95	10	721	721	NUM
admet-2334	95	11	-	-	NUM
admet-2334	95	12	736	736	NUM
admet-2334	95	13	designing	design	VERB
admet-2334	95	14	the	the	DET
admet-2334	95	15	next	next	ADJ
admet-2334	95	16	generation	generation	NOUN
admet-2334	95	17	of	of	ADP
admet-2334	95	18	oral	oral	ADJ
admet-2334	95	19	beyond	beyond	ADP
admet-2334	95	20	rule	rule	NOUN
admet-2334	95	21	of	of	ADP
admet-2334	95	22	five	five	NUM
admet-2334	95	23	drugs	drug	NOUN
admet-2334	95	24	doi	doi	NOUN
admet-2334	95	25	:	:	PUNCT
admet-2334	95	26	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	95	27	725	725	NUM
admet-2334	95	28	this	this	DET
admet-2334	95	29	context	context	NOUN
admet-2334	95	30	,	,	PUNCT
admet-2334	95	31	the	the	DET
admet-2334	95	32	lipophilicity	lipophilicity	NOUN
admet-2334	95	33	of	of	ADP
admet-2334	95	34	a	a	DET
admet-2334	95	35	certain	certain	ADJ
admet-2334	95	36	molecule	molecule	NOUN
admet-2334	95	37	is	be	AUX
admet-2334	95	38	measured	measure	VERB
admet-2334	95	39	as	as	ADP
admet-2334	95	40	the	the	DET
admet-2334	95	41	capacity	capacity	NOUN
admet-2334	95	42	or	or	CCONJ
admet-2334	95	43	retention	retention	NOUN
admet-2334	95	44	factor	factor	NOUN
admet-2334	95	45	(	(	PUNCT
admet-2334	95	46	k	k	NOUN
admet-2334	95	47	'	'	X
admet-2334	95	48	,	,	PUNCT
admet-2334	95	49	more	more	ADV
admet-2334	95	50	often	often	ADV
admet-2334	95	51	expressed	express	VERB
admet-2334	95	52	as	as	ADP
admet-2334	95	53	log	log	NOUN
admet-2334	95	54	k	k	NOUN
admet-2334	95	55	'	'	PUNCT
admet-2334	95	56	)	)	PUNCT
admet-2334	95	57	on	on	ADP
admet-2334	95	58	a	a	DET
admet-2334	95	59	certain	certain	ADJ
admet-2334	95	60	reverse	reverse	NOUN
admet-2334	95	61	-	-	PUNCT
admet-2334	95	62	phase	phase	NOUN
admet-2334	95	63	column	column	NOUN
admet-2334	95	64	(	(	PUNCT
admet-2334	95	65	rp	rp	NOUN
admet-2334	95	66	-	-	PUNCT
admet-2334	95	67	hplc	hplc	NOUN
admet-2334	95	68	)	)	PUNCT
admet-2334	95	69	at	at	ADP
admet-2334	95	70	a	a	DET
admet-2334	95	71	certain	certain	ADJ
admet-2334	95	72	mobile	mobile	ADJ
admet-2334	95	73	phase	phase	NOUN
admet-2334	95	74	composition	composition	NOUN
admet-2334	95	75	.	.	PUNCT
admet-2334	96	1	formally	formally	ADV
admet-2334	96	2	,	,	PUNCT
admet-2334	96	3	k	k	PRON
admet-2334	96	4	'	'	PUNCT
admet-2334	96	5	is	be	AUX
admet-2334	96	6	defined	define	VERB
admet-2334	96	7	as	as	ADP
admet-2334	96	8	the	the	DET
admet-2334	96	9	difference	difference	NOUN
admet-2334	96	10	between	between	ADP
admet-2334	96	11	the	the	DET
admet-2334	96	12	retention	retention	NOUN
admet-2334	96	13	time	time	NOUN
admet-2334	96	14	of	of	ADP
admet-2334	96	15	the	the	DET
admet-2334	96	16	analyte	analyte	NOUN
admet-2334	96	17	(	(	PUNCT
admet-2334	96	18	tr	tr	VERB
admet-2334	96	19	)	)	PUNCT
admet-2334	96	20	and	and	CCONJ
admet-2334	96	21	the	the	DET
admet-2334	96	22	dead	dead	ADJ
admet-2334	96	23	time	time	NOUN
admet-2334	96	24	of	of	ADP
admet-2334	96	25	the	the	DET
admet-2334	96	26	column	column	NOUN
admet-2334	96	27	(	(	PUNCT
admet-2334	96	28	t0	t0	NOUN
admet-2334	96	29	)	)	PUNCT
admet-2334	96	30	,	,	PUNCT
admet-2334	96	31	divided	divide	VERB
admet-2334	96	32	by	by	ADP
admet-2334	96	33	the	the	DET
admet-2334	96	34	dead	dead	ADJ
admet-2334	96	35	time	time	NOUN
admet-2334	96	36	itself	itself	PRON
admet-2334	96	37	(	(	PUNCT
admet-2334	96	38	t0	t0	PROPN
admet-2334	96	39	)	)	PUNCT
admet-2334	96	40	,	,	PUNCT
admet-2334	96	41	equation	equation	NOUN
admet-2334	96	42	1	1	NUM
admet-2334	96	43	:	:	PUNCT
admet-2334	96	44	k′	k′	X
admet-2334	96	45	=	=	PUNCT
admet-2334	96	46	(	(	PUNCT
admet-2334	96	47	tr	tr	PUNCT
admet-2334	96	48	t0)/t0	t0)/t0	NOUN
admet-2334	96	49	(	(	PUNCT
admet-2334	96	50	1	1	NUM
admet-2334	96	51	)	)	PUNCT
admet-2334	96	52	under	under	ADP
admet-2334	96	53	reverse	reverse	ADJ
admet-2334	96	54	phase	phase	NOUN
admet-2334	96	55	(	(	PUNCT
admet-2334	96	56	rp)-hplc	rp)-hplc	NOUN
admet-2334	96	57	conditions	condition	NOUN
admet-2334	96	58	,	,	PUNCT
admet-2334	96	59	the	the	DET
admet-2334	96	60	compounds	compound	NOUN
admet-2334	96	61	are	be	AUX
admet-2334	96	62	retained	retain	VERB
admet-2334	96	63	proportionally	proportionally	ADV
admet-2334	96	64	to	to	ADP
admet-2334	96	65	their	their	PRON
admet-2334	96	66	partition	partition	NOUN
admet-2334	96	67	coefficient	coefficient	NOUN
admet-2334	96	68	(	(	PUNCT
admet-2334	96	69	generally	generally	ADV
admet-2334	96	70	in	in	ADP
admet-2334	96	71	the	the	DET
admet-2334	96	72	octanol	octanol	NOUN
admet-2334	96	73	/	/	SYM
admet-2334	96	74	water	water	NOUN
admet-2334	96	75	system	system	NOUN
admet-2334	96	76	)	)	PUNCT
admet-2334	96	77	.	.	PUNCT
admet-2334	97	1	the	the	DET
admet-2334	97	2	use	use	NOUN
admet-2334	97	3	of	of	ADP
admet-2334	97	4	rp	rp	NOUN
admet-2334	97	5	-	-	PUNCT
admet-2334	97	6	hplc	hplc	NOUN
admet-2334	97	7	for	for	ADP
admet-2334	97	8	lipophilicity	lipophilicity	NOUN
admet-2334	97	9	has	have	AUX
admet-2334	97	10	been	be	AUX
admet-2334	97	11	exploited	exploit	VERB
admet-2334	97	12	in	in	ADP
admet-2334	97	13	the	the	DET
admet-2334	97	14	last	last	ADJ
admet-2334	97	15	two	two	NUM
admet-2334	97	16	decades	decade	NOUN
admet-2334	97	17	by	by	ADP
admet-2334	97	18	various	various	ADJ
admet-2334	97	19	academic	academic	ADJ
admet-2334	97	20	groups	group	NOUN
admet-2334	97	21	and	and	CCONJ
admet-2334	97	22	companies	company	NOUN
admet-2334	97	23	,	,	PUNCT
admet-2334	97	24	mainly	mainly	ADV
admet-2334	97	25	to	to	PART
admet-2334	97	26	provide	provide	VERB
admet-2334	97	27	octanol	octanol	NOUN
admet-2334	97	28	/	/	SYM
admet-2334	97	29	water	water	NOUN
admet-2334	97	30	surrogates	surrogate	NOUN
admet-2334	97	31	.	.	PUNCT
admet-2334	98	1	valko	valko	PROPN
admet-2334	98	2	and	and	CCONJ
admet-2334	98	3	coworkers	coworker	NOUN
admet-2334	98	4	developed	develop	VERB
admet-2334	98	5	the	the	DET
admet-2334	98	6	chromatographic	chromatographic	ADJ
admet-2334	98	7	hydrophobicity	hydrophobicity	NOUN
admet-2334	98	8	index	index	NOUN
admet-2334	98	9	(	(	PUNCT
admet-2334	98	10	chi	chi	NOUN
admet-2334	98	11	)	)	PUNCT
admet-2334	98	12	at	at	ADP
admet-2334	98	13	glaxosmithkline	glaxosmithkline	PROPN
admet-2334	98	14	(	(	PUNCT
admet-2334	98	15	gsk	gsk	NOUN
admet-2334	98	16	)	)	PUNCT
admet-2334	99	1	[	[	X
admet-2334	99	2	20	20	NUM
admet-2334	99	3	]	]	PUNCT
admet-2334	99	4	,	,	PUNCT
admet-2334	99	5	pfizer	pfizer	NOUN
admet-2334	99	6	developed	develop	VERB
admet-2334	99	7	its	its	PRON
admet-2334	99	8	own	own	ADJ
admet-2334	99	9	lipophilicity	lipophilicity	NOUN
admet-2334	99	10	descriptors	descriptor	NOUN
admet-2334	99	11	(	(	PUNCT
admet-2334	99	12	elogp	elogp	NOUN
admet-2334	99	13	or	or	CCONJ
admet-2334	99	14	elogd	elogd	ADJ
admet-2334	99	15	)	)	PUNCT
admet-2334	100	1	[	[	X
admet-2334	100	2	21,22	21,22	X
admet-2334	100	3	]	]	X
admet-2334	100	4	and	and	CCONJ
admet-2334	100	5	we	we	PRON
admet-2334	100	6	developed	develop	VERB
admet-2334	100	7	brlogd	brlogd	VERB
admet-2334	100	8	[	[	X
admet-2334	100	9	23	23	NUM
admet-2334	100	10	]	]	PUNCT
admet-2334	100	11	.	.	PUNCT
admet-2334	101	1	it	it	PRON
admet-2334	101	2	should	should	AUX
admet-2334	101	3	be	be	AUX
admet-2334	101	4	emphasized	emphasize	VERB
admet-2334	101	5	that	that	SCONJ
admet-2334	101	6	chromatographic	chromatographic	ADJ
admet-2334	101	7	methods	method	NOUN
admet-2334	101	8	do	do	AUX
admet-2334	101	9	not	not	PART
admet-2334	101	10	directly	directly	ADV
admet-2334	101	11	measure	measure	VERB
admet-2334	101	12	log	log	NOUN
admet-2334	101	13	d	d	NOUN
admet-2334	101	14	and	and	CCONJ
admet-2334	101	15	thus	thus	ADV
admet-2334	101	16	they	they	PRON
admet-2334	101	17	require	require	VERB
admet-2334	101	18	careful	careful	ADJ
admet-2334	101	19	validation	validation	NOUN
admet-2334	101	20	in	in	ADP
admet-2334	101	21	terms	term	NOUN
admet-2334	101	22	of	of	ADP
admet-2334	101	23	the	the	DET
admet-2334	101	24	balance	balance	NOUN
admet-2334	101	25	of	of	ADP
admet-2334	101	26	intermolecular	intermolecular	ADJ
admet-2334	101	27	forces	force	NOUN
admet-2334	101	28	governing	govern	VERB
admet-2334	101	29	the	the	DET
admet-2334	101	30	retention	retention	NOUN
admet-2334	101	31	that	that	PRON
admet-2334	101	32	should	should	AUX
admet-2334	101	33	be	be	AUX
admet-2334	101	34	the	the	DET
admet-2334	101	35	same	same	ADJ
admet-2334	101	36	than	than	ADP
admet-2334	101	37	those	those	PRON
admet-2334	101	38	governing	govern	VERB
admet-2334	101	39	partitioning	partition	VERB
admet-2334	101	40	in	in	ADP
admet-2334	101	41	a	a	DET
admet-2334	101	42	biphasic	biphasic	ADJ
admet-2334	101	43	octanol	octanol	NOUN
admet-2334	101	44	/	/	SYM
admet-2334	101	45	water	water	NOUN
admet-2334	101	46	system	system	NOUN
admet-2334	101	47	.	.	PUNCT
admet-2334	102	1	this	this	DET
admet-2334	102	2	validation	validation	NOUN
admet-2334	102	3	can	can	AUX
admet-2334	102	4	be	be	AUX
admet-2334	102	5	obtained	obtain	VERB
admet-2334	102	6	by	by	ADP
admet-2334	102	7	different	different	ADJ
admet-2334	102	8	strategies	strategy	NOUN
admet-2334	102	9	,	,	PUNCT
admet-2334	102	10	e.g.	e.g.	ADV
admet-2334	102	11	,	,	PUNCT
admet-2334	102	12	the	the	DET
admet-2334	102	13	abraham	abraham	PROPN
admet-2334	102	14	’s	’s	PART
admet-2334	102	15	descriptors	descriptor	NOUN
admet-2334	102	16	[	[	X
admet-2334	102	17	24	24	NUM
admet-2334	102	18	]	]	PUNCT
admet-2334	102	19	and/or	and/or	CCONJ
admet-2334	102	20	the	the	DET
admet-2334	102	21	block	block	NOUN
admet-2334	102	22	relevance	relevance	NOUN
admet-2334	102	23	(	(	PUNCT
admet-2334	102	24	br	br	NOUN
admet-2334	102	25	)	)	PUNCT
admet-2334	102	26	analysis	analysis	NOUN
admet-2334	102	27	method	method	NOUN
admet-2334	102	28	[	[	X
admet-2334	102	29	25	25	NUM
admet-2334	102	30	]	]	PUNCT
admet-2334	102	31	.	.	PUNCT
admet-2334	103	1	log	log	VERB
admet-2334	103	2	p/	p/	NUM
admet-2334	103	3	log	log	NOUN
admet-2334	103	4	doct	doct	NOUN
admet-2334	103	5	and	and	CCONJ
admet-2334	103	6	their	their	PRON
admet-2334	103	7	chromatographic	chromatographic	ADJ
admet-2334	103	8	surrogates	surrogate	NOUN
admet-2334	103	9	are	be	AUX
admet-2334	103	10	popular	popular	ADJ
admet-2334	103	11	to	to	PART
admet-2334	103	12	model	model	VERB
admet-2334	103	13	the	the	DET
admet-2334	103	14	“	"	PUNCT
admet-2334	103	15	average	average	ADJ
admet-2334	103	16	”	"	PUNCT
admet-2334	103	17	lipophilicity	lipophilicity	NOUN
admet-2334	103	18	of	of	ADP
admet-2334	103	19	compounds	compound	NOUN
admet-2334	103	20	in	in	ADP
admet-2334	103	21	the	the	DET
admet-2334	103	22	complex	complex	ADJ
admet-2334	103	23	membrane	membrane	NOUN
admet-2334	103	24	bilayer	bilayer	NOUN
admet-2334	103	25	environment	environment	NOUN
admet-2334	103	26	,	,	PUNCT
admet-2334	103	27	but	but	CCONJ
admet-2334	103	28	log	log	VERB
admet-2334	103	29	palk	palk	NOUN
admet-2334	103	30	(	(	PUNCT
admet-2334	103	31	alkane	alkane	NOUN
admet-2334	103	32	/	/	SYM
admet-2334	103	33	water	water	NOUN
admet-2334	103	34	)	)	PUNCT
admet-2334	103	35	and	and	CCONJ
admet-2334	103	36	log	log	VERB
admet-2334	103	37	ptol	ptol	NOUN
admet-2334	103	38	(	(	PUNCT
admet-2334	103	39	toluene	toluene	NOUN
admet-2334	103	40	/	/	SYM
admet-2334	103	41	water	water	NOUN
admet-2334	103	42	)	)	PUNCT
admet-2334	103	43	better	well	ADV
admet-2334	103	44	mimic	mimic	VERB
admet-2334	103	45	the	the	DET
admet-2334	103	46	polarity	polarity	NOUN
admet-2334	103	47	of	of	ADP
admet-2334	103	48	the	the	DET
admet-2334	103	49	membrane	membrane	ADJ
admet-2334	103	50	interior	interior	NOUN
admet-2334	103	51	(	(	PUNCT
admet-2334	103	52	dielectric	dielectric	ADJ
admet-2334	103	53	constant	constant	ADJ
admet-2334	103	54	∼2	∼2	PROPN
admet-2334	103	55	)	)	PUNCT
admet-2334	103	56	.	.	PUNCT
admet-2334	104	1	also	also	ADV
admet-2334	104	2	,	,	PUNCT
admet-2334	104	3	in	in	ADP
admet-2334	104	4	this	this	DET
admet-2334	104	5	case	case	NOUN
admet-2334	104	6	,	,	PUNCT
admet-2334	104	7	chromatography	chromatography	NOUN
admet-2334	104	8	provides	provide	VERB
admet-2334	104	9	surrogates	surrogate	NOUN
admet-2334	104	10	thanks	thank	NOUN
admet-2334	104	11	to	to	ADP
admet-2334	104	12	the	the	DET
admet-2334	104	13	wide	wide	ADJ
admet-2334	104	14	variety	variety	NOUN
admet-2334	104	15	of	of	ADP
admet-2334	104	16	columns	column	NOUN
admet-2334	104	17	and	and	CCONJ
admet-2334	104	18	eluents	eluent	NOUN
admet-2334	104	19	available	available	ADJ
admet-2334	104	20	.	.	PUNCT
admet-2334	105	1	for	for	ADP
admet-2334	105	2	instance	instance	NOUN
admet-2334	105	3	,	,	PUNCT
admet-2334	105	4	the	the	DET
admet-2334	105	5	plrp	plrp	NOUN
admet-2334	105	6	-	-	PUNCT
admet-2334	105	7	s	s	X
admet-2334	105	8	(	(	PUNCT
admet-2334	105	9	polystyrene	polystyrene	NOUN
admet-2334	105	10	/	/	SYM
admet-2334	105	11	divinylbenzene	divinylbenzene	NOUN
admet-2334	105	12	)	)	PUNCT
admet-2334	105	13	is	be	AUX
admet-2334	105	14	a	a	DET
admet-2334	105	15	polymeric	polymeric	ADJ
admet-2334	105	16	column	column	NOUN
admet-2334	105	17	that	that	PRON
admet-2334	105	18	mimics	mimic	VERB
admet-2334	105	19	the	the	DET
admet-2334	105	20	alkylic	alkylic	ADJ
admet-2334	105	21	chains	chain	NOUN
admet-2334	105	22	of	of	ADP
admet-2334	105	23	phospholipids	phospholipid	NOUN
admet-2334	105	24	.	.	PUNCT
admet-2334	106	1	in	in	ADP
admet-2334	106	2	this	this	DET
admet-2334	106	3	context	context	NOUN
admet-2334	106	4	,	,	PUNCT
admet-2334	106	5	our	our	PRON
admet-2334	106	6	group	group	NOUN
admet-2334	106	7	revealed	reveal	VERB
admet-2334	106	8	that	that	SCONJ
admet-2334	106	9	the	the	DET
admet-2334	106	10	capacity	capacity	NOUN
admet-2334	106	11	factor	factor	NOUN
admet-2334	106	12	at	at	ADP
admet-2334	106	13	80	80	NUM
admet-2334	106	14	%	%	NOUN
admet-2334	106	15	acetonitrile	acetonitrile	NOUN
admet-2334	106	16	(	(	PUNCT
admet-2334	106	17	log	log	NOUN
admet-2334	106	18	k	k	NOUN
admet-2334	106	19	'	'	PART
admet-2334	106	20	80	80	NUM
admet-2334	106	21	plrps	plrps	NOUN
admet-2334	106	22	)	)	PUNCT
admet-2334	106	23	can	can	AUX
admet-2334	106	24	be	be	AUX
admet-2334	106	25	a	a	DET
admet-2334	106	26	rough	rough	ADJ
admet-2334	106	27	surrogate	surrogate	NOUN
admet-2334	106	28	of	of	ADP
admet-2334	106	29	the	the	DET
admet-2334	106	30	log	log	NOUN
admet-2334	106	31	ptol	ptol	NOUN
admet-2334	107	1	[	[	X
admet-2334	107	2	26	26	NUM
admet-2334	107	3	]	]	PUNCT
admet-2334	107	4	.	.	PUNCT
admet-2334	108	1	furthermore	furthermore	ADV
admet-2334	108	2	,	,	PUNCT
admet-2334	108	3	rp	rp	NOUN
admet-2334	108	4	-	-	PUNCT
admet-2334	108	5	hplc	hplc	NOUN
admet-2334	108	6	methods	method	NOUN
admet-2334	108	7	generate	generate	VERB
admet-2334	108	8	biomimetic	biomimetic	ADJ
admet-2334	108	9	environments	environment	NOUN
admet-2334	108	10	.	.	PUNCT
admet-2334	109	1	for	for	ADP
admet-2334	109	2	example	example	NOUN
admet-2334	109	3	,	,	PUNCT
admet-2334	109	4	immobilized	immobilize	VERB
admet-2334	109	5	artificial	artificial	ADJ
admet-2334	109	6	membrane	membrane	NOUN
admet-2334	109	7	(	(	PUNCT
admet-2334	109	8	iam	iam	PROPN
admet-2334	109	9	)	)	PUNCT
admet-2334	109	10	chromatography	chromatography	NOUN
admet-2334	109	11	,	,	PUNCT
admet-2334	109	12	first	first	ADV
admet-2334	109	13	introduced	introduce	VERB
admet-2334	109	14	by	by	ADP
admet-2334	109	15	charles	charles	PROPN
admet-2334	109	16	pidgeon	pidgeon	NOUN
admet-2334	109	17	and	and	CCONJ
admet-2334	109	18	his	his	PRON
admet-2334	109	19	colleagues	colleague	NOUN
admet-2334	109	20	[	[	X
admet-2334	109	21	27	27	NUM
admet-2334	109	22	]	]	PUNCT
admet-2334	109	23	,	,	PUNCT
admet-2334	109	24	is	be	AUX
admet-2334	109	25	used	use	VERB
admet-2334	109	26	to	to	PART
admet-2334	109	27	simulate	simulate	VERB
admet-2334	109	28	biological	biological	ADJ
admet-2334	109	29	cell	cell	NOUN
admet-2334	109	30	membranes	membrane	NOUN
admet-2334	109	31	.	.	PUNCT
admet-2334	110	1	iam	iam	PROPN
admet-2334	110	2	columns	column	NOUN
admet-2334	110	3	consist	consist	VERB
admet-2334	110	4	of	of	ADP
admet-2334	110	5	a	a	DET
admet-2334	110	6	monolayer	monolayer	NOUN
admet-2334	110	7	of	of	ADP
admet-2334	110	8	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2334	110	9	covalently	covalently	ADV
admet-2334	110	10	bound	bind	VERB
admet-2334	110	11	to	to	ADP
admet-2334	110	12	an	an	DET
admet-2334	110	13	inert	inert	ADJ
admet-2334	110	14	silica	silica	NOUN
admet-2334	110	15	support	support	NOUN
admet-2334	110	16	.	.	PUNCT
admet-2334	111	1	the	the	DET
admet-2334	111	2	reference	reference	NOUN
admet-2334	111	3	descriptor	descriptor	NOUN
admet-2334	111	4	is	be	AUX
admet-2334	111	5	the	the	DET
admet-2334	111	6	logarithm	logarithm	NOUN
admet-2334	111	7	of	of	ADP
admet-2334	111	8	the	the	DET
admet-2334	111	9	capacity	capacity	NOUN
admet-2334	111	10	factor	factor	NOUN
admet-2334	111	11	at	at	ADP
admet-2334	111	12	0	0	NUM
admet-2334	111	13	%	%	NOUN
admet-2334	111	14	organic	organic	ADJ
admet-2334	111	15	solvent	solvent	NOUN
admet-2334	111	16	(	(	PUNCT
admet-2334	111	17	extrapolated	extrapolate	VERB
admet-2334	111	18	value	value	NOUN
admet-2334	111	19	)	)	PUNCT
admet-2334	111	20	,	,	PUNCT
admet-2334	111	21	named	name	VERB
admet-2334	111	22	log	log	PROPN
admet-2334	111	23	kw	kw	PROPN
admet-2334	111	24	iam	iam	PROPN
admet-2334	111	25	.	.	PUNCT
admet-2334	112	1	in	in	ADP
admet-2334	112	2	the	the	DET
admet-2334	112	3	iam	iam	PROPN
admet-2334	112	4	system	system	NOUN
admet-2334	112	5	,	,	PUNCT
admet-2334	112	6	the	the	DET
admet-2334	112	7	retention	retention	NOUN
admet-2334	112	8	of	of	ADP
admet-2334	112	9	charged	charge	VERB
admet-2334	112	10	molecules	molecule	NOUN
admet-2334	112	11	also	also	ADV
admet-2334	112	12	depends	depend	VERB
admet-2334	112	13	on	on	ADP
admet-2334	112	14	the	the	DET
admet-2334	112	15	electrostatic	electrostatic	ADJ
admet-2334	112	16	interactions	interaction	NOUN
admet-2334	112	17	with	with	ADP
admet-2334	112	18	the	the	DET
admet-2334	112	19	phospholipid	phospholipid	NOUN
admet-2334	112	20	heads	head	NOUN
admet-2334	112	21	[	[	X
admet-2334	112	22	28	28	NUM
admet-2334	112	23	]	]	PUNCT
admet-2334	112	24	.	.	PUNCT
admet-2334	113	1	generally	generally	ADV
admet-2334	113	2	speaking	speak	VERB
admet-2334	113	3	,	,	PUNCT
admet-2334	113	4	it	it	PRON
admet-2334	113	5	has	have	AUX
admet-2334	113	6	been	be	AUX
admet-2334	113	7	found	find	VERB
admet-2334	113	8	that	that	SCONJ
admet-2334	113	9	iam	iam	PROPN
admet-2334	113	10	columns	column	NOUN
admet-2334	113	11	strongly	strongly	ADV
admet-2334	113	12	retain	retain	VERB
admet-2334	113	13	positively	positively	ADV
admet-2334	113	14	charged	charge	VERB
admet-2334	113	15	compounds	compound	NOUN
admet-2334	113	16	as	as	SCONJ
admet-2334	113	17	the	the	DET
admet-2334	113	18	iam	iam	PROPN
admet-2334	113	19	columns	column	NOUN
admet-2334	113	20	are	be	AUX
admet-2334	113	21	negatively	negatively	ADV
admet-2334	113	22	charged	charge	VERB
admet-2334	113	23	on	on	ADP
admet-2334	113	24	the	the	DET
admet-2334	113	25	surface	surface	NOUN
admet-2334	113	26	,	,	PUNCT
admet-2334	113	27	like	like	ADP
admet-2334	113	28	cell	cell	NOUN
admet-2334	113	29	membranes	membrane	NOUN
admet-2334	113	30	.	.	PUNCT
admet-2334	114	1	overall	overall	ADV
admet-2334	114	2	,	,	PUNCT
admet-2334	114	3	we	we	PRON
admet-2334	114	4	recommend	recommend	VERB
admet-2334	114	5	measuring	measure	VERB
admet-2334	114	6	lipophilicity	lipophilicity	NOUN
admet-2334	114	7	in	in	ADP
admet-2334	114	8	multiple	multiple	ADJ
admet-2334	114	9	systems	system	NOUN
admet-2334	114	10	to	to	PART
admet-2334	114	11	fully	fully	ADV
admet-2334	114	12	assess	assess	VERB
admet-2334	114	13	the	the	DET
admet-2334	114	14	lipophilic	lipophilic	ADJ
admet-2334	114	15	behaviour	behaviour	NOUN
admet-2334	114	16	of	of	ADP
admet-2334	114	17	bro5	bro5	NOUN
admet-2334	114	18	compounds	compound	NOUN
admet-2334	114	19	,	,	PUNCT
admet-2334	114	20	as	as	SCONJ
admet-2334	114	21	these	these	DET
admet-2334	114	22	molecules	molecule	NOUN
admet-2334	114	23	are	be	AUX
admet-2334	114	24	likely	likely	ADJ
admet-2334	114	25	to	to	PART
admet-2334	114	26	change	change	VERB
admet-2334	114	27	their	their	PRON
admet-2334	114	28	conformation	conformation	NOUN
admet-2334	114	29	and	and	CCONJ
admet-2334	114	30	,	,	PUNCT
admet-2334	114	31	consequently	consequently	ADV
admet-2334	114	32	,	,	PUNCT
admet-2334	114	33	their	their	PRON
admet-2334	114	34	lipophilicity	lipophilicity	NOUN
admet-2334	114	35	depending	depend	VERB
admet-2334	114	36	on	on	ADP
admet-2334	114	37	the	the	DET
admet-2334	114	38	environment	environment	NOUN
admet-2334	114	39	.	.	PUNCT
admet-2334	115	1	polarity	polarity	NOUN
admet-2334	115	2	while	while	SCONJ
admet-2334	115	3	generally	generally	ADV
admet-2334	115	4	less	less	ADV
admet-2334	115	5	important	important	ADJ
admet-2334	115	6	than	than	ADP
admet-2334	115	7	hydrophobicity	hydrophobicity	NOUN
admet-2334	115	8	in	in	ADP
admet-2334	115	9	defining	define	VERB
admet-2334	115	10	lipophilicity	lipophilicity	NOUN
admet-2334	115	11	,	,	PUNCT
admet-2334	115	12	the	the	DET
admet-2334	115	13	significance	significance	NOUN
admet-2334	115	14	of	of	ADP
admet-2334	115	15	polarity	polarity	NOUN
admet-2334	115	16	varies	vary	VERB
admet-2334	115	17	depending	depend	VERB
admet-2334	115	18	on	on	ADP
admet-2334	115	19	the	the	DET
admet-2334	115	20	system	system	NOUN
admet-2334	115	21	being	be	AUX
admet-2334	115	22	considered	consider	VERB
admet-2334	115	23	.	.	PUNCT
admet-2334	116	1	experimentally	experimentally	ADV
admet-2334	116	2	,	,	PUNCT
admet-2334	116	3	it	it	PRON
admet-2334	116	4	can	can	AUX
admet-2334	116	5	be	be	AUX
admet-2334	116	6	measured	measure	VERB
admet-2334	116	7	by	by	ADP
admet-2334	116	8	chromatographic	chromatographic	ADJ
admet-2334	116	9	methods	method	NOUN
admet-2334	116	10	.	.	PUNCT
admet-2334	117	1	up	up	ADP
admet-2334	117	2	to	to	ADP
admet-2334	117	3	now	now	ADV
admet-2334	117	4	,	,	PUNCT
admet-2334	117	5	two	two	NUM
admet-2334	117	6	experimental	experimental	ADJ
admet-2334	117	7	polarity	polarity	NOUN
admet-2334	117	8	descriptors	descriptor	NOUN
admet-2334	117	9	have	have	AUX
admet-2334	117	10	been	be	AUX
admet-2334	117	11	used	use	VERB
admet-2334	117	12	in	in	ADP
admet-2334	117	13	the	the	DET
admet-2334	117	14	bro5	bro5	NOUN
admet-2334	117	15	space	space	NOUN
admet-2334	117	16	:	:	PUNCT
admet-2334	117	17	epsa	epsa	NOUN
admet-2334	117	18	and	and	CCONJ
admet-2334	117	19			NOUN
admet-2334	117	20	log	log	VERB
admet-2334	117	21	kw	kw	PROPN
admet-2334	117	22	iam	iam	PROPN
admet-2334	117	23	.	.	PUNCT
admet-2334	118	1	the	the	DET
admet-2334	118	2	epsa	epsa	NOUN
admet-2334	118	3	method	method	NOUN
admet-2334	118	4	has	have	AUX
admet-2334	118	5	been	be	AUX
admet-2334	118	6	developed	develop	VERB
admet-2334	118	7	in	in	ADP
admet-2334	118	8	pfizer	pfizer	NOUN
admet-2334	118	9	[	[	X
admet-2334	118	10	29,30	29,30	NUM
admet-2334	118	11	]	]	PUNCT
admet-2334	118	12	.	.	PUNCT
admet-2334	119	1	this	this	PRON
admet-2334	119	2	is	be	AUX
admet-2334	119	3	a	a	DET
admet-2334	119	4	supercritical	supercritical	ADJ
admet-2334	119	5	fluid	fluid	NOUN
admet-2334	119	6	chromatographic	chromatographic	ADJ
admet-2334	119	7	(	(	PUNCT
admet-2334	119	8	sfc	sfc	NOUN
admet-2334	119	9	)	)	PUNCT
admet-2334	119	10	method	method	NOUN
admet-2334	119	11	that	that	PRON
admet-2334	119	12	employs	employ	VERB
admet-2334	119	13	a	a	DET
admet-2334	119	14	supercritical	supercritical	ADJ
admet-2334	119	15	fluid	fluid	NOUN
admet-2334	119	16	as	as	ADP
admet-2334	119	17	the	the	DET
admet-2334	119	18	mobile	mobile	ADJ
admet-2334	119	19	phase	phase	NOUN
admet-2334	119	20	(	(	PUNCT
admet-2334	119	21	typically	typically	ADV
admet-2334	119	22	co₂	co₂	NOUN
admet-2334	119	23	)	)	PUNCT
admet-2334	119	24	and	and	CCONJ
admet-2334	119	25	a	a	DET
admet-2334	119	26	normal	normal	ADJ
admet-2334	119	27	phase	phase	NOUN
admet-2334	119	28	column	column	NOUN
admet-2334	119	29	(	(	PUNCT
admet-2334	119	30	chirex	chirex	NOUN
admet-2334	119	31	3014	3014	NUM
admet-2334	119	32	)	)	PUNCT
admet-2334	119	33	as	as	ADP
admet-2334	119	34	the	the	DET
admet-2334	119	35	stationary	stationary	ADJ
admet-2334	119	36	phase	phase	NOUN
admet-2334	119	37	.	.	PUNCT
admet-2334	120	1	it	it	PRON
admet-2334	120	2	displays	display	VERB
admet-2334	120	3	a	a	DET
admet-2334	120	4	balance	balance	NOUN
admet-2334	120	5	of	of	ADP
admet-2334	120	6	lipophilic	lipophilic	ADJ
admet-2334	120	7	and	and	CCONJ
admet-2334	120	8	polar	polar	ADJ
admet-2334	120	9	attributes	attribute	NOUN
admet-2334	120	10	that	that	PRON
admet-2334	120	11	efficiently	efficiently	ADV
admet-2334	120	12	separates	separate	VERB
admet-2334	120	13	compounds	compound	NOUN
admet-2334	120	14	according	accord	VERB
admet-2334	120	15	to	to	ADP
admet-2334	120	16	their	their	PRON
admet-2334	120	17	polarity	polarity	NOUN
admet-2334	120	18	.	.	PUNCT
admet-2334	121	1	in	in	ADP
admet-2334	121	2	this	this	DET
admet-2334	121	3	system	system	NOUN
admet-2334	121	4	,	,	PUNCT
admet-2334	121	5	the	the	DET
admet-2334	121	6	polarity	polarity	NOUN
admet-2334	121	7	of	of	ADP
admet-2334	121	8	the	the	DET
admet-2334	121	9	eluent	eluent	NOUN
admet-2334	121	10	is	be	AUX
admet-2334	121	11	modified	modify	VERB
admet-2334	121	12	as	as	ADP
admet-2334	121	13	a	a	DET
admet-2334	121	14	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	NOUN
admet-2334	121	15	d.	d.	PROPN
admet-2334	121	16	g.	g.	PROPN
admet-2334	121	17	jiménez	jiménez	PROPN
admet-2334	121	18	et	et	PROPN
admet-2334	121	19	al	al	PROPN
admet-2334	121	20	.	.	PROPN
admet-2334	121	21	admet	admet	PROPN
admet-2334	121	22	&	&	CCONJ
admet-2334	121	23	dmpk	dmpk	PROPN
admet-2334	121	24	12(5	12(5	NUM
admet-2334	121	25	)	)	PUNCT
admet-2334	121	26	(	(	PUNCT
admet-2334	121	27	2024	2024	NUM
admet-2334	121	28	)	)	PUNCT
admet-2334	121	29	721	721	NUM
admet-2334	121	30	-	-	NUM
admet-2334	121	31	736	736	NUM
admet-2334	121	32	726	726	NUM
admet-2334	121	33	gradient	gradient	NOUN
admet-2334	121	34	by	by	ADP
admet-2334	121	35	varying	vary	VERB
admet-2334	121	36	the	the	DET
admet-2334	121	37	percentage	percentage	NOUN
admet-2334	121	38	of	of	ADP
admet-2334	121	39	methanol	methanol	NOUN
admet-2334	121	40	in	in	ADP
admet-2334	121	41	an	an	DET
admet-2334	121	42	ammonium	ammonium	NOUN
admet-2334	121	43	formate	formate	NOUN
admet-2334	121	44	solution	solution	NOUN
admet-2334	121	45	.	.	PUNCT
admet-2334	122	1	this	this	PRON
admet-2334	122	2	generates	generate	VERB
admet-2334	122	3	a	a	DET
admet-2334	122	4	nonpolar	nonpolar	ADJ
admet-2334	122	5	system	system	NOUN
admet-2334	122	6	that	that	PRON
admet-2334	122	7	favours	favour	VERB
admet-2334	122	8	folded	fold	VERB
admet-2334	122	9	conformations	conformation	NOUN
admet-2334	122	10	,	,	PUNCT
admet-2334	122	11	thereby	thereby	ADV
admet-2334	122	12	allowing	allow	VERB
admet-2334	122	13	the	the	DET
admet-2334	122	14	determination	determination	NOUN
admet-2334	122	15	of	of	ADP
admet-2334	122	16	a	a	DET
admet-2334	122	17	polarity	polarity	NOUN
admet-2334	122	18	index	index	NOUN
admet-2334	122	19	,	,	PUNCT
admet-2334	122	20	designated	designate	VERB
admet-2334	122	21	epsa	epsa	NOUN
admet-2334	122	22	,	,	PUNCT
admet-2334	122	23	and	and	CCONJ
admet-2334	122	24	the	the	DET
admet-2334	122	25	monitoring	monitoring	NOUN
admet-2334	122	26	of	of	ADP
admet-2334	122	27	the	the	DET
admet-2334	122	28	presence	presence	NOUN
admet-2334	122	29	of	of	ADP
admet-2334	122	30	imhbs	imhbs	NOUN
admet-2334	122	31	.	.	PUNCT
admet-2334	123	1			PROPN
admet-2334	124	1	log	log	VERB
admet-2334	124	2	kw	kw	PROPN
admet-2334	124	3	iam	iam	PROPN
admet-2334	124	4	was	be	AUX
admet-2334	124	5	developed	develop	VERB
admet-2334	124	6	in	in	ADP
admet-2334	124	7	1997	1997	NUM
admet-2334	124	8	by	by	ADP
admet-2334	124	9	barbato	barbato	NOUN
admet-2334	124	10	and	and	CCONJ
admet-2334	124	11	colleagues	colleague	NOUN
admet-2334	125	1	[	[	X
admet-2334	125	2	28	28	NUM
admet-2334	125	3	]	]	PUNCT
admet-2334	125	4	and	and	CCONJ
admet-2334	125	5	is	be	AUX
admet-2334	125	6	based	base	VERB
admet-2334	125	7	on	on	ADP
admet-2334	125	8	the	the	DET
admet-2334	125	9	evidence	evidence	NOUN
admet-2334	125	10	that	that	PRON
admet-2334	125	11	log	log	VERB
admet-2334	125	12	kw	kw	PROPN
admet-2334	125	13	iam	iam	PROPN
admet-2334	125	14	(	(	PUNCT
admet-2334	125	15	see	see	VERB
admet-2334	125	16	above	above	ADV
admet-2334	125	17	)	)	PUNCT
admet-2334	125	18	also	also	ADV
admet-2334	125	19	includes	include	VERB
admet-2334	125	20	the	the	DET
admet-2334	125	21	contribution	contribution	NOUN
admet-2334	125	22	of	of	ADP
admet-2334	125	23	the	the	DET
admet-2334	125	24	electrostatic	electrostatic	ADJ
admet-2334	125	25	interactions	interaction	NOUN
admet-2334	125	26	between	between	ADP
admet-2334	125	27	ionized	ionized	ADJ
admet-2334	125	28	compounds	compound	NOUN
admet-2334	125	29	and	and	CCONJ
admet-2334	125	30	the	the	DET
admet-2334	125	31	phospholipid	phospholipid	NOUN
admet-2334	125	32	heads	head	NOUN
admet-2334	125	33	,	,	PUNCT
admet-2334	125	34	not	not	PART
admet-2334	125	35	detectable	detectable	ADJ
admet-2334	125	36	by	by	ADP
admet-2334	125	37	descriptors	descriptor	NOUN
admet-2334	125	38	related	relate	VERB
admet-2334	125	39	to	to	ADP
admet-2334	125	40	biphasic	biphasic	ADJ
admet-2334	125	41	systems	system	NOUN
admet-2334	125	42	,	,	PUNCT
admet-2334	125	43	like	like	ADP
admet-2334	125	44	octanol	octanol	NOUN
admet-2334	125	45	/	/	SYM
admet-2334	125	46	water	water	NOUN
admet-2334	125	47	and	and	CCONJ
admet-2334	125	48	toluene	toluene	ADJ
admet-2334	125	49	/	/	SYM
admet-2334	125	50	water	water	NOUN
admet-2334	125	51	.	.	PUNCT
admet-2334	126	1	without	without	ADP
admet-2334	126	2	entering	enter	VERB
admet-2334	126	3	the	the	DET
admet-2334	126	4	method	method	NOUN
admet-2334	126	5	details	detail	NOUN
admet-2334	126	6	that	that	PRON
admet-2334	126	7	can	can	AUX
admet-2334	126	8	be	be	AUX
admet-2334	126	9	retrieved	retrieve	VERB
admet-2334	126	10	in	in	ADP
admet-2334	126	11	the	the	DET
admet-2334	126	12	literature	literature	NOUN
admet-2334	126	13	[	[	X
admet-2334	126	14	28,31,32	28,31,32	NUM
admet-2334	126	15	]	]	PUNCT
admet-2334	126	16	,	,	PUNCT
admet-2334	126	17			PUNCT
admet-2334	126	18	log	log	VERB
admet-2334	126	19	kw	kw	PROPN
admet-2334	126	20	iam	iam	PROPN
admet-2334	126	21	represents	represent	VERB
admet-2334	126	22	the	the	DET
admet-2334	126	23	polarity	polarity	NOUN
admet-2334	126	24	of	of	ADP
admet-2334	126	25	the	the	DET
admet-2334	126	26	analyte	analyte	NOUN
admet-2334	126	27	.	.	PUNCT
admet-2334	127	1	epsa	epsa	NOUN
admet-2334	127	2	and	and	CCONJ
admet-2334	127	3			NOUN
admet-2334	127	4	log	log	VERB
admet-2334	127	5	kw	kw	PROPN
admet-2334	127	6	iam	iam	PROPN
admet-2334	127	7	offer	offer	VERB
admet-2334	127	8	distinct	distinct	ADJ
admet-2334	127	9	pieces	piece	NOUN
admet-2334	127	10	of	of	ADP
admet-2334	127	11	information	information	NOUN
admet-2334	127	12	.	.	PUNCT
admet-2334	128	1	this	this	PRON
admet-2334	128	2	is	be	AUX
admet-2334	128	3	explained	explain	VERB
admet-2334	128	4	in	in	ADP
admet-2334	128	5	figure	figure	NOUN
admet-2334	128	6	4	4	NUM
admet-2334	128	7	,	,	PUNCT
admet-2334	128	8	which	which	PRON
admet-2334	128	9	compares	compare	VERB
admet-2334	128	10	the	the	DET
admet-2334	128	11	block	block	NOUN
admet-2334	128	12	relevance	relevance	NOUN
admet-2334	128	13	(	(	PUNCT
admet-2334	128	14	br	br	NOUN
admet-2334	128	15	)	)	PUNCT
admet-2334	128	16	graphical	graphical	ADJ
admet-2334	128	17	output	output	NOUN
admet-2334	128	18	obtained	obtain	VERB
admet-2334	128	19	for	for	ADP
admet-2334	128	20	the	the	DET
admet-2334	128	21	three	three	NUM
admet-2334	128	22	polarity	polarity	NOUN
admet-2334	128	23	descriptors	descriptor	NOUN
admet-2334	128	24	:	:	PUNCT
admet-2334	128	25	the	the	DET
admet-2334	128	26	topological	topological	ADJ
admet-2334	128	27	polar	polar	ADJ
admet-2334	128	28	surface	surface	NOUN
admet-2334	128	29	area	area	NOUN
admet-2334	128	30	(	(	PUNCT
admet-2334	128	31	tpsa	tpsa	PROPN
admet-2334	128	32	)	)	PUNCT
admet-2334	128	33	,	,	PUNCT
admet-2334	128	34	epsa	epsa	NOUN
admet-2334	128	35	and	and	CCONJ
admet-2334	128	36			NOUN
admet-2334	128	37	log	log	VERB
admet-2334	128	38	kw	kw	PROPN
admet-2334	128	39	iam	iam	PROPN
admet-2334	129	1	[	[	X
admet-2334	129	2	32,33	32,33	NUM
admet-2334	129	3	]	]	PUNCT
admet-2334	129	4	.	.	PUNCT
admet-2334	130	1	figure	figure	NOUN
admet-2334	130	2	4	4	NUM
admet-2334	130	3	.	.	PUNCT
admet-2334	131	1	br	br	ADP
admet-2334	131	2	analysis	analysis	NOUN
admet-2334	131	3	(	(	PUNCT
admet-2334	131	4	a	a	DET
admet-2334	131	5	computational	computational	ADJ
admet-2334	131	6	tool	tool	NOUN
admet-2334	131	7	that	that	PRON
admet-2334	131	8	allows	allow	VERB
admet-2334	131	9	the	the	DET
admet-2334	131	10	interpretation	interpretation	NOUN
admet-2334	131	11	of	of	ADP
admet-2334	131	12	the	the	DET
admet-2334	131	13	balance	balance	NOUN
admet-2334	131	14	of	of	ADP
admet-2334	131	15	intermolecular	intermolecular	ADJ
admet-2334	131	16	interactions	interaction	NOUN
admet-2334	131	17	governing	govern	VERB
admet-2334	131	18	systems	system	NOUN
admet-2334	131	19	,	,	PUNCT
admet-2334	131	20	on	on	ADP
admet-2334	131	21	the	the	DET
admet-2334	131	22	y	y	PROPN
admet-2334	131	23	axis	axis	NOUN
admet-2334	131	24	the	the	DET
admet-2334	131	25	value	value	NOUN
admet-2334	131	26	of	of	ADP
admet-2334	131	27	the	the	DET
admet-2334	131	28	block	block	NOUN
admet-2334	131	29	,	,	PUNCT
admet-2334	131	30	on	on	ADP
admet-2334	131	31	the	the	DET
admet-2334	131	32	x	x	PUNCT
admet-2334	131	33	axis	axis	NOUN
admet-2334	131	34	the	the	DET
admet-2334	131	35	block	block	NOUN
admet-2334	131	36	)	)	PUNCT
admet-2334	131	37	for	for	ADP
admet-2334	131	38	polarity	polarity	NOUN
admet-2334	131	39	descriptors	descriptor	NOUN
admet-2334	131	40	.	.	PUNCT
admet-2334	132	1	(	(	PUNCT
admet-2334	132	2	a	a	X
admet-2334	132	3	)	)	PUNCT
admet-2334	132	4	tpsa	tpsa	NOUN
admet-2334	132	5	,	,	PUNCT
admet-2334	132	6	(	(	PUNCT
admet-2334	132	7	b	b	X
admet-2334	132	8	)	)	PUNCT
admet-2334	132	9	epsa	epsa	NOUN
admet-2334	132	10	and	and	CCONJ
admet-2334	132	11	(	(	PUNCT
admet-2334	132	12	c	c	NOUN
admet-2334	132	13	)	)	PUNCT
admet-2334	132	14			NOUN
admet-2334	132	15	log	log	VERB
admet-2334	132	16	kw	kw	PROPN
admet-2334	132	17	iam	iam	PROPN
admet-2334	132	18	.	.	PUNCT
admet-2334	133	1	in	in	ADP
admet-2334	133	2	practice	practice	NOUN
admet-2334	133	3	,	,	PUNCT
admet-2334	133	4	the	the	DET
admet-2334	133	5	br	br	NOUN
admet-2334	133	6	analysis	analysis	NOUN
admet-2334	133	7	is	be	AUX
admet-2334	133	8	a	a	DET
admet-2334	133	9	computational	computational	ADJ
admet-2334	133	10	tool	tool	NOUN
admet-2334	133	11	that	that	PRON
admet-2334	133	12	allows	allow	VERB
admet-2334	133	13	the	the	DET
admet-2334	133	14	interpretation	interpretation	NOUN
admet-2334	133	15	of	of	ADP
admet-2334	133	16	the	the	DET
admet-2334	133	17	balance	balance	NOUN
admet-2334	133	18	of	of	ADP
admet-2334	133	19	intermolecular	intermolecular	ADJ
admet-2334	133	20	interactions	interaction	NOUN
admet-2334	133	21	governing	govern	VERB
admet-2334	133	22	systems	system	NOUN
admet-2334	133	23	,	,	PUNCT
admet-2334	133	24	including	include	VERB
admet-2334	133	25	chromatographic	chromatographic	ADJ
admet-2334	133	26	ones	one	NOUN
admet-2334	133	27	.	.	PUNCT
admet-2334	134	1	since	since	SCONJ
admet-2334	134	2	tpsa	tpsa	NOUN
admet-2334	134	3	is	be	AUX
admet-2334	134	4	the	the	DET
admet-2334	134	5	most	most	ADV
admet-2334	134	6	obvious	obvious	ADJ
admet-2334	134	7	polarity	polarity	NOUN
admet-2334	134	8	descriptor	descriptor	NOUN
admet-2334	134	9	,	,	PUNCT
admet-2334	134	10	epsa	epsa	NOUN
admet-2334	134	11	and	and	CCONJ
admet-2334	134	12			NOUN
admet-2334	134	13	log	log	PROPN
admet-2334	134	14	kwiam	kwiam	PROPN
admet-2334	134	15	are	be	AUX
admet-2334	134	16	expected	expect	VERB
admet-2334	134	17	to	to	PART
admet-2334	134	18	show	show	VERB
admet-2334	134	19	br	br	NOUN
admet-2334	134	20	plots	plot	NOUN
admet-2334	134	21	similar	similar	ADJ
admet-2334	134	22	to	to	ADP
admet-2334	134	23	tpsa	tpsa	PROPN
admet-2334	134	24	.	.	PUNCT
admet-2334	135	1	however	however	ADV
admet-2334	135	2	,	,	PUNCT
admet-2334	135	3	this	this	PRON
admet-2334	135	4	is	be	AUX
admet-2334	135	5	not	not	PART
admet-2334	135	6	completely	completely	ADV
admet-2334	135	7	verified	verify	VERB
admet-2334	135	8	for	for	ADP
admet-2334	135	9	epsa	epsa	NOUN
admet-2334	135	10	since	since	SCONJ
admet-2334	135	11	hbd	hbd	NOUN
admet-2334	135	12	and	and	CCONJ
admet-2334	135	13	hba	hba	NOUN
admet-2334	135	14	blocks	block	NOUN
admet-2334	135	15	(	(	PUNCT
admet-2334	135	16	red	red	ADJ
admet-2334	135	17	and	and	CCONJ
admet-2334	135	18	blue	blue	ADJ
admet-2334	135	19	,	,	PUNCT
admet-2334	135	20	respectively	respectively	ADV
admet-2334	135	21	)	)	PUNCT
admet-2334	135	22	have	have	VERB
admet-2334	135	23	opposite	opposite	ADJ
admet-2334	135	24	signs	sign	NOUN
admet-2334	135	25	,	,	PUNCT
admet-2334	135	26	while	while	SCONJ
admet-2334	135	27	the	the	DET
admet-2334	135	28	reverse	reverse	NOUN
admet-2334	135	29	is	be	AUX
admet-2334	135	30	true	true	ADJ
admet-2334	135	31	for	for	ADP
admet-2334	135	32	tpsa	tpsa	NOUN
admet-2334	135	33	and	and	CCONJ
admet-2334	135	34			NOUN
admet-2334	135	35	log	log	VERB
admet-2334	135	36	kw	kw	PROPN
admet-2334	135	37	iam	iam	PROPN
admet-2334	135	38	.	.	PUNCT
admet-2334	136	1	in	in	ADP
admet-2334	136	2	practice	practice	NOUN
admet-2334	136	3	,	,	PUNCT
admet-2334	136	4	the	the	DET
admet-2334	136	5	hbd	hbd	NOUN
admet-2334	136	6	properties	property	NOUN
admet-2334	136	7	of	of	ADP
admet-2334	136	8	the	the	DET
admet-2334	136	9	molecule	molecule	NOUN
admet-2334	136	10	can	can	AUX
admet-2334	136	11	be	be	AUX
admet-2334	136	12	underestimated	underestimate	VERB
admet-2334	136	13	by	by	ADP
admet-2334	136	14	epsa	epsa	NOUN
admet-2334	136	15	when	when	SCONJ
admet-2334	136	16	the	the	DET
admet-2334	136	17	structure	structure	NOUN
admet-2334	136	18	includes	include	VERB
admet-2334	136	19	multiple	multiple	ADJ
admet-2334	136	20	hba	hba	NOUN
admet-2334	136	21	groups	group	NOUN
admet-2334	136	22	.	.	PUNCT
admet-2334	137	1	polarity	polarity	NOUN
admet-2334	137	2	is	be	AUX
admet-2334	137	3	often	often	ADV
admet-2334	137	4	computationally	computationally	ADV
admet-2334	137	5	quantified	quantify	VERB
admet-2334	137	6	by	by	ADP
admet-2334	137	7	the	the	DET
admet-2334	137	8	polar	polar	ADJ
admet-2334	137	9	surface	surface	NOUN
admet-2334	137	10	area	area	NOUN
admet-2334	137	11	(	(	PUNCT
admet-2334	137	12	psa	psa	NOUN
admet-2334	137	13	)	)	PUNCT
admet-2334	137	14	.	.	PUNCT
admet-2334	138	1	several	several	ADJ
admet-2334	138	2	methods	method	NOUN
admet-2334	138	3	have	have	AUX
admet-2334	138	4	been	be	AUX
admet-2334	138	5	suggested	suggest	VERB
admet-2334	138	6	to	to	PART
admet-2334	138	7	calculate	calculate	VERB
admet-2334	138	8	the	the	DET
admet-2334	138	9	3d	3d	NUM
admet-2334	138	10	molecular	molecular	ADJ
admet-2334	138	11	polar	polar	ADJ
admet-2334	138	12	surface	surface	NOUN
admet-2334	138	13	area	area	NOUN
admet-2334	138	14	(	(	PUNCT
admet-2334	138	15	3d	3d	PROPN
admet-2334	138	16	psa	psa	NOUN
admet-2334	138	17	)	)	PUNCT
admet-2334	138	18	,	,	PUNCT
admet-2334	138	19	but	but	CCONJ
admet-2334	138	20	they	they	PRON
admet-2334	138	21	rarely	rarely	ADV
admet-2334	138	22	reach	reach	VERB
admet-2334	138	23	a	a	DET
admet-2334	138	24	consensus	consensus	NOUN
admet-2334	138	25	.	.	PUNCT
admet-2334	139	1	in	in	ADP
admet-2334	139	2	practice	practice	NOUN
admet-2334	139	3	,	,	PUNCT
admet-2334	139	4	for	for	ADP
admet-2334	139	5	the	the	DET
admet-2334	139	6	sake	sake	NOUN
admet-2334	139	7	of	of	ADP
admet-2334	139	8	simplicity	simplicity	NOUN
admet-2334	139	9	,	,	PUNCT
admet-2334	139	10	we	we	PRON
admet-2334	139	11	prefer	prefer	VERB
admet-2334	139	12	to	to	PART
admet-2334	139	13	choose	choose	VERB
admet-2334	139	14	a	a	DET
admet-2334	139	15	3d	3d	NUM
admet-2334	139	16	psa	psa	NOUN
admet-2334	139	17	descriptor	descriptor	NOUN
admet-2334	139	18	comparable	comparable	ADJ
admet-2334	139	19	to	to	ADP
admet-2334	139	20	the	the	DET
admet-2334	139	21	2d	2d	NUM
admet-2334	139	22	topological	topological	ADJ
admet-2334	139	23	psa	psa	NOUN
admet-2334	139	24	(	(	PUNCT
admet-2334	139	25	tpsa	tpsa	PROPN
admet-2334	139	26	)	)	PUNCT
admet-2334	139	27	.	.	PUNCT
admet-2334	140	1	to	to	PART
admet-2334	140	2	reach	reach	VERB
admet-2334	140	3	this	this	DET
admet-2334	140	4	aim	aim	NOUN
admet-2334	140	5	,	,	PUNCT
admet-2334	140	6	we	we	PRON
admet-2334	140	7	adopt	adopt	VERB
admet-2334	140	8	the	the	DET
admet-2334	140	9	following	follow	VERB
admet-2334	140	10	pair	pair	NOUN
admet-2334	140	11	of	of	ADP
admet-2334	140	12	tools	tool	NOUN
admet-2334	140	13	(	(	PUNCT
admet-2334	140	14	see	see	VERB
admet-2334	140	15	methods	method	NOUN
admet-2334	140	16	):	):	PUNCT
admet-2334	140	17	tpsa	tpsa	NOUN
admet-2334	140	18	calculated	calculate	VERB
admet-2334	140	19	by	by	ADP
admet-2334	140	20	alvadesc	alvadesc	NOUN
admet-2334	140	21	and	and	CCONJ
admet-2334	140	22	the	the	DET
admet-2334	140	23	3d	3d	PROPN
admet-2334	140	24	psa	psa	NOUN
admet-2334	140	25	calculated	calculate	VERB
admet-2334	140	26	with	with	ADP
admet-2334	140	27	vega	vega	PROPN
admet-2334	140	28	zz	zz	PROPN
admet-2334	140	29	(	(	PUNCT
admet-2334	140	30	probe	probe	NOUN
admet-2334	140	31	radius	radius	NOUN
admet-2334	140	32	0	0	NUM
admet-2334	140	33	å	å	NOUN
admet-2334	140	34	)	)	PUNCT
admet-2334	140	35	.	.	PUNCT
admet-2334	141	1	in	in	ADP
admet-2334	141	2	a	a	DET
admet-2334	141	3	recent	recent	ADJ
admet-2334	141	4	paper	paper	NOUN
admet-2334	141	5	,	,	PUNCT
admet-2334	141	6	price	price	NOUN
admet-2334	141	7	et	et	NOUN
admet-2334	141	8	al	al	PROPN
admet-2334	141	9	.	.	PUNCT
admet-2334	142	1	[	[	X
admet-2334	142	2	34	34	NUM
admet-2334	142	3	]	]	PUNCT
admet-2334	142	4	who	who	PRON
admet-2334	142	5	also	also	ADV
admet-2334	142	6	established	establish	VERB
admet-2334	142	7	a	a	DET
admet-2334	142	8	new	new	ADJ
admet-2334	142	9	high	high	ADJ
admet-2334	142	10	-	-	PUNCT
admet-2334	142	11	throughput	throughput	NOUN
admet-2334	142	12	method	method	NOUN
admet-2334	142	13	to	to	PART
admet-2334	142	14	measure	measure	VERB
admet-2334	142	15	the	the	DET
admet-2334	142	16	epsa	epsa	NOUN
admet-2334	142	17	named	name	VERB
admet-2334	142	18	ht	ht	NOUN
admet-2334	142	19	-	-	PUNCT
admet-2334	142	20	epsa	epsa	NOUN
admet-2334	142	21	[	[	X
admet-2334	142	22	35	35	NUM
admet-2334	142	23	]	]	PUNCT
admet-2334	142	24	introduced	introduce	VERB
admet-2334	142	25	etr	etr	PROPN
admet-2334	142	26	,	,	PUNCT
admet-2334	142	27	the	the	DET
admet-2334	142	28	epsa	epsa	NOUN
admet-2334	142	29	-	-	PUNCT
admet-2334	142	30	to	to	ADP
admet-2334	142	31	-	-	PUNCT
admet-2334	142	32	topological	topological	ADJ
admet-2334	142	33	polar	polar	ADJ
admet-2334	142	34	surface	surface	NOUN
admet-2334	142	35	area	area	NOUN
admet-2334	142	36	(	(	PUNCT
admet-2334	142	37	tpsa	tpsa	NOUN
admet-2334	142	38	)	)	PUNCT
admet-2334	142	39	ratio	ratio	NOUN
admet-2334	142	40	.	.	PUNCT
admet-2334	143	1	the	the	DET
admet-2334	143	2	researchers	researcher	NOUN
admet-2334	143	3	suggest	suggest	VERB
admet-2334	143	4	that	that	SCONJ
admet-2334	143	5	etr	etr	PROPN
admet-2334	143	6	in	in	ADP
admet-2334	143	7	combination	combination	NOUN
admet-2334	143	8	with	with	ADP
admet-2334	143	9	ab	ab	X
admet-2334	143	10	-	-	PUNCT
admet-2334	143	11	mps	mps	PROPN
admet-2334	143	12	(	(	PUNCT
admet-2334	143	13	a	a	DET
admet-2334	143	14	multiparametric	multiparametric	ADJ
admet-2334	143	15	scoring	scoring	NOUN
admet-2334	143	16	function	function	NOUN
admet-2334	143	17	including	include	VERB
admet-2334	143	18	log	log	PROPN
admet-2334	143	19	d	d	PROPN
admet-2334	143	20	,	,	PUNCT
admet-2334	143	21	the	the	DET
admet-2334	143	22	number	number	NOUN
admet-2334	143	23	of	of	ADP
admet-2334	143	24	rotatable	rotatable	ADJ
admet-2334	143	25	bonds	bond	NOUN
admet-2334	143	26	,	,	PUNCT
admet-2334	143	27	and	and	CCONJ
admet-2334	143	28	the	the	DET
admet-2334	143	29	number	number	NOUN
admet-2334	143	30	of	of	ADP
admet-2334	143	31	aromatic	aromatic	ADJ
admet-2334	143	32	rings	ring	NOUN
admet-2334	143	33	[	[	X
admet-2334	143	34	36	36	NUM
admet-2334	143	35	]	]	PUNCT
admet-2334	143	36	)	)	PUNCT
admet-2334	143	37	identifies	identify	VERB
admet-2334	143	38	unique	unique	ADJ
admet-2334	143	39	subsets	subset	NOUN
admet-2334	143	40	of	of	ADP
admet-2334	143	41	bro5	bro5	NOUN
admet-2334	143	42	and	and	CCONJ
admet-2334	143	43	protacs	protac	NOUN
admet-2334	143	44	,	,	PUNCT
admet-2334	143	45	enabling	enable	VERB
admet-2334	143	46	specialized	specialized	ADJ
admet-2334	143	47	drug	drug	NOUN
admet-2334	143	48	design	design	NOUN
admet-2334	143	49	strategies	strategy	NOUN
admet-2334	143	50	for	for	ADP
admet-2334	143	51	improved	improved	ADJ
admet-2334	143	52	absorption	absorption	NOUN
admet-2334	143	53	.	.	PUNCT
admet-2334	144	1	finally	finally	ADV
admet-2334	144	2	,	,	PUNCT
admet-2334	144	3	it	it	PRON
admet-2334	144	4	should	should	AUX
admet-2334	144	5	be	be	AUX
admet-2334	144	6	mentioned	mention	VERB
admet-2334	144	7	that	that	SCONJ
admet-2334	144	8	the	the	DET
admet-2334	144	9	compound	compound	NOUN
admet-2334	144	10	's	's	PART
admet-2334	144	11	ability	ability	NOUN
admet-2334	144	12	to	to	PART
admet-2334	144	13	form	form	VERB
admet-2334	144	14	imhbs	imhbs	NOUN
admet-2334	144	15	is	be	AUX
admet-2334	144	16	strictly	strictly	ADV
admet-2334	144	17	related	relate	VERB
admet-2334	144	18	to	to	ADP
admet-2334	144	19	polarity	polarity	NOUN
admet-2334	144	20	.	.	PUNCT
admet-2334	145	1	to	to	PART
admet-2334	145	2	experimentally	experimentally	ADV
admet-2334	145	3	assess	assess	VERB
admet-2334	145	4	the	the	DET
admet-2334	145	5	presence	presence	NOUN
admet-2334	145	6	of	of	ADP
admet-2334	145	7	imhbs	imhbs	NOUN
admet-2334	145	8	,	,	PUNCT
admet-2334	145	9	the	the	DET
admet-2334	145	10	difference	difference	NOUN
admet-2334	145	11	between	between	ADP
admet-2334	145	12	the	the	DET
admet-2334	145	13	log	log	NOUN
admet-2334	145	14	p	p	X
admet-2334	145	15	/	/	SYM
admet-2334	145	16	d	d	NOUN
admet-2334	145	17	in	in	ADP
admet-2334	145	18	octanol	octanol	NOUN
admet-2334	145	19	/	/	SYM
admet-2334	145	20	water	water	NOUN
admet-2334	145	21	and	and	CCONJ
admet-2334	145	22	the	the	DET
admet-2334	145	23	log	log	NOUN
admet-2334	145	24	p	p	X
admet-2334	145	25	/	/	SYM
admet-2334	145	26	d	d	NOUN
admet-2334	145	27	in	in	ADP
admet-2334	145	28	toluene	toluene	NOUN
admet-2334	145	29	/	/	SYM
admet-2334	145	30	water	water	NOUN
admet-2334	145	31	systems	system	NOUN
admet-2334	145	32	can	can	AUX
admet-2334	145	33	be	be	AUX
admet-2334	145	34	used	use	VERB
admet-2334	145	35	and	and	CCONJ
admet-2334	145	36			AUX
admet-2334	145	37	log	log	VERB
admet-2334	145	38	poct	poct	NOUN
admet-2334	145	39	-	-	PUNCT
admet-2334	145	40	tol	tol	NOUN
admet-2334	145	41	has	have	AUX
admet-2334	145	42	been	be	AUX
admet-2334	145	43	validated	validate	VERB
admet-2334	145	44	as	as	ADP
admet-2334	145	45	an	an	DET
admet-2334	145	46	optimal	optimal	ADJ
admet-2334	145	47	strategy	strategy	NOUN
admet-2334	145	48	to	to	PART
admet-2334	145	49	reveal	reveal	VERB
admet-2334	145	50	imhb	imhb	ADJ
admet-2334	145	51	formation	formation	NOUN
admet-2334	146	1	[	[	X
admet-2334	146	2	37	37	NUM
admet-2334	146	3	]	]	PUNCT
admet-2334	146	4	.	.	PUNCT
admet-2334	147	1	however	however	ADV
admet-2334	147	2	,	,	PUNCT
admet-2334	147	3	the	the	DET
admet-2334	147	4	poor	poor	ADJ
admet-2334	147	5	solubility	solubility	NOUN
admet-2334	147	6	of	of	ADP
admet-2334	147	7	bro5	bro5	NOUN
admet-2334	147	8	molecules	molecule	NOUN
admet-2334	147	9	in	in	ADP
admet-2334	147	10	toluene	toluene	NOUN
admet-2334	147	11	hinders	hinder	VERB
admet-2334	147	12	its	its	PRON
admet-2334	147	13	application	application	NOUN
admet-2334	147	14	to	to	ADP
admet-2334	147	15	the	the	DET
admet-2334	147	16	-2.5	-2.5	ADJ
admet-2334	147	17	-1.5	-1.5	PUNCT
admet-2334	147	18	-0.5	-0.5	PROPN
admet-2334	147	19	0.5	0.5	NUM
admet-2334	147	20	1.5	1.5	NUM
admet-2334	147	21	2.5	2.5	NUM
admet-2334	147	22	size	size	NOUN
admet-2334	147	23	oh2	oh2	NOUN
admet-2334	147	24	dry	dry	ADJ
admet-2334	147	25	o	o	NOUN
admet-2334	147	26	n1	n1	ADJ
admet-2334	147	27	others	other	NOUN
admet-2334	147	28	-2.5	-2.5	PROPN
admet-2334	147	29	-1.5	-1.5	PUNCT
admet-2334	147	30	-0.5	-0.5	PROPN
admet-2334	147	31	0.5	0.5	NUM
admet-2334	147	32	1.5	1.5	NUM
admet-2334	147	33	2.5	2.5	NUM
admet-2334	147	34	size	size	NOUN
admet-2334	147	35	oh2	oh2	NOUN
admet-2334	147	36	dry	dry	ADJ
admet-2334	147	37	o	o	NOUN
admet-2334	147	38	n1	n1	ADJ
admet-2334	147	39	others	other	NOUN
admet-2334	147	40	-2.5	-2.5	PROPN
admet-2334	147	41	-1.5	-1.5	PUNCT
admet-2334	147	42	-0.5	-0.5	PROPN
admet-2334	147	43	0.5	0.5	NUM
admet-2334	147	44	1.5	1.5	NUM
admet-2334	147	45	2.5	2.5	NUM
admet-2334	147	46	size	size	NOUN
admet-2334	147	47	oh2	oh2	NOUN
admet-2334	147	48	dry	dry	ADJ
admet-2334	147	49	o	o	PROPN
admet-2334	147	50	n1	n1	ADJ
admet-2334	147	51	others	other	NOUN
admet-2334	147	52	epsa	epsa	NOUN
admet-2334	147	53			NOUN
admet-2334	147	54	log	log	VERB
admet-2334	147	55	kw	kw	INTJ
admet-2334	147	56	iamtpsa	iamtpsa	PROPN
admet-2334	147	57	ba	ba	PROPN
admet-2334	147	58	c	c	PROPN
admet-2334	147	59	admet	admet	PROPN
admet-2334	147	60	&	&	CCONJ
admet-2334	147	61	dmpk	dmpk	PROPN
admet-2334	147	62	12(5	12(5	NUM
admet-2334	147	63	)	)	PUNCT
admet-2334	147	64	(	(	PUNCT
admet-2334	147	65	2024	2024	NUM
admet-2334	147	66	)	)	PUNCT
admet-2334	147	67	721	721	NUM
admet-2334	147	68	-	-	NUM
admet-2334	147	69	736	736	NUM
admet-2334	147	70	designing	design	VERB
admet-2334	147	71	the	the	DET
admet-2334	147	72	next	next	ADJ
admet-2334	147	73	generation	generation	NOUN
admet-2334	147	74	of	of	ADP
admet-2334	147	75	oral	oral	ADJ
admet-2334	147	76	beyond	beyond	ADP
admet-2334	147	77	rule	rule	NOUN
admet-2334	147	78	of	of	ADP
admet-2334	147	79	five	five	NUM
admet-2334	147	80	drugs	drug	NOUN
admet-2334	147	81	doi	doi	NOUN
admet-2334	147	82	:	:	PUNCT
admet-2334	147	83	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	147	84	727	727	NUM
admet-2334	147	85	bro5	bro5	NOUN
admet-2334	147	86	space	space	NOUN
admet-2334	147	87	.	.	PUNCT
admet-2334	148	1	moreover	moreover	ADV
admet-2334	148	2	,	,	PUNCT
admet-2334	148	3	epsa	epsa	NOUN
admet-2334	148	4	could	could	AUX
admet-2334	148	5	also	also	ADV
admet-2334	148	6	provide	provide	VERB
admet-2334	148	7	information	information	NOUN
admet-2334	148	8	on	on	ADP
admet-2334	148	9	imhb	imhb	ADJ
admet-2334	148	10	formation	formation	NOUN
admet-2334	148	11	,	,	PUNCT
admet-2334	148	12	given	give	VERB
admet-2334	148	13	that	that	SCONJ
admet-2334	148	14	suitable	suitable	ADJ
admet-2334	148	15	pairs	pair	NOUN
admet-2334	148	16	of	of	ADP
admet-2334	148	17	compounds	compound	NOUN
admet-2334	148	18	are	be	AUX
admet-2334	148	19	available	available	ADJ
admet-2334	148	20	.	.	PUNCT
admet-2334	149	1	chameleonicity	chameleonicity	NOUN
admet-2334	149	2	few	few	ADJ
admet-2334	149	3	tools	tool	NOUN
admet-2334	149	4	are	be	AUX
admet-2334	149	5	available	available	ADJ
admet-2334	149	6	to	to	PART
admet-2334	149	7	determine	determine	VERB
admet-2334	149	8	chameleonicity	chameleonicity	NOUN
admet-2334	149	9	,	,	PUNCT
admet-2334	149	10	all	all	ADV
admet-2334	149	11	with	with	ADP
admet-2334	149	12	important	important	ADJ
admet-2334	149	13	limitations	limitation	NOUN
admet-2334	149	14	.	.	PUNCT
admet-2334	150	1	the	the	DET
admet-2334	150	2	most	most	ADV
admet-2334	150	3	straightforward	straightforward	ADJ
admet-2334	150	4	method	method	NOUN
admet-2334	150	5	is	be	AUX
admet-2334	150	6	to	to	PART
admet-2334	150	7	compare	compare	VERB
admet-2334	150	8	the	the	DET
admet-2334	150	9	x	x	ADJ
admet-2334	150	10	-	-	NOUN
admet-2334	150	11	ray	ray	NOUN
admet-2334	150	12	crystallographic	crystallographic	ADJ
admet-2334	150	13	conformations	conformation	NOUN
admet-2334	150	14	of	of	ADP
admet-2334	150	15	the	the	DET
admet-2334	150	16	compound	compound	NOUN
admet-2334	150	17	crystallized	crystallize	VERB
admet-2334	150	18	in	in	ADP
admet-2334	150	19	both	both	CCONJ
admet-2334	150	20	polar	polar	ADJ
admet-2334	150	21	and	and	CCONJ
admet-2334	150	22	nonpolar	nonpolar	ADJ
admet-2334	150	23	solvents	solvent	NOUN
admet-2334	150	24	[	[	X
admet-2334	150	25	38	38	NUM
admet-2334	150	26	]	]	PUNCT
admet-2334	150	27	.	.	PUNCT
admet-2334	151	1	this	this	PRON
admet-2334	151	2	allows	allow	VERB
admet-2334	151	3	to	to	PART
admet-2334	151	4	identify	identify	VERB
admet-2334	151	5	structural	structural	ADJ
admet-2334	151	6	indicators	indicator	NOUN
admet-2334	151	7	of	of	ADP
admet-2334	151	8	the	the	DET
admet-2334	151	9	chameleonic	chameleonic	ADJ
admet-2334	151	10	effect	effect	NOUN
admet-2334	151	11	by	by	ADP
admet-2334	151	12	monitoring	monitor	VERB
admet-2334	151	13	polarity	polarity	NOUN
admet-2334	151	14	and	and	CCONJ
admet-2334	151	15	shape	shape	NOUN
admet-2334	151	16	variations	variation	NOUN
admet-2334	151	17	.	.	PUNCT
admet-2334	152	1	however	however	ADV
admet-2334	152	2	,	,	PUNCT
admet-2334	152	3	molecular	molecular	ADJ
admet-2334	152	4	structures	structure	NOUN
admet-2334	152	5	are	be	AUX
admet-2334	152	6	often	often	ADV
admet-2334	152	7	crystallized	crystallize	VERB
admet-2334	152	8	in	in	ADP
admet-2334	152	9	the	the	DET
admet-2334	152	10	same	same	ADJ
admet-2334	152	11	solvent	solvent	NOUN
admet-2334	152	12	due	due	ADP
admet-2334	152	13	to	to	ADP
admet-2334	152	14	solubility	solubility	NOUN
admet-2334	152	15	limitations	limitation	NOUN
admet-2334	152	16	,	,	PUNCT
admet-2334	152	17	which	which	PRON
admet-2334	152	18	is	be	AUX
admet-2334	152	19	suboptimal	suboptimal	ADJ
admet-2334	152	20	for	for	ADP
admet-2334	152	21	studying	study	VERB
admet-2334	152	22	dynamic	dynamic	ADJ
admet-2334	152	23	behaviours	behaviour	NOUN
admet-2334	152	24	.	.	PUNCT
admet-2334	153	1	moreover	moreover	ADV
admet-2334	153	2	,	,	PUNCT
admet-2334	153	3	x	x	ADJ
admet-2334	153	4	-	-	ADJ
admet-2334	153	5	raybased	raybase	VERB
admet-2334	153	6	chameleonicity	chameleonicity	NOUN
admet-2334	153	7	analysis	analysis	NOUN
admet-2334	153	8	is	be	AUX
admet-2334	153	9	susceptible	susceptible	ADJ
admet-2334	153	10	to	to	ADP
admet-2334	153	11	the	the	DET
admet-2334	153	12	"	"	PUNCT
admet-2334	153	13	crystal	crystal	NOUN
admet-2334	153	14	packing	packing	NOUN
admet-2334	153	15	effect	effect	NOUN
admet-2334	153	16	,	,	PUNCT
admet-2334	153	17	"	"	PUNCT
admet-2334	153	18	where	where	SCONJ
admet-2334	153	19	crystallized	crystallize	VERB
admet-2334	153	20	conformations	conformation	NOUN
admet-2334	153	21	may	may	AUX
admet-2334	153	22	not	not	PART
admet-2334	153	23	accurately	accurately	ADV
admet-2334	153	24	represent	represent	VERB
admet-2334	153	25	those	those	PRON
admet-2334	153	26	in	in	ADP
admet-2334	153	27	solution	solution	NOUN
admet-2334	153	28	.	.	PUNCT
admet-2334	154	1	nuclear	nuclear	ADJ
admet-2334	154	2	magnetic	magnetic	ADJ
admet-2334	154	3	resonance	resonance	NOUN
admet-2334	154	4	(	(	PUNCT
admet-2334	154	5	nmr	nmr	NOUN
admet-2334	154	6	)	)	PUNCT
admet-2334	154	7	serves	serve	VERB
admet-2334	154	8	as	as	ADP
admet-2334	154	9	a	a	DET
admet-2334	154	10	more	more	ADV
admet-2334	154	11	sophisticated	sophisticated	ADJ
admet-2334	154	12	approach	approach	NOUN
admet-2334	154	13	,	,	PUNCT
admet-2334	154	14	relying	rely	VERB
admet-2334	154	15	on	on	ADP
admet-2334	154	16	the	the	DET
admet-2334	154	17	generation	generation	NOUN
admet-2334	154	18	of	of	ADP
admet-2334	154	19	molecular	molecular	ADJ
admet-2334	154	20	constraints	constraint	NOUN
admet-2334	154	21	extracted	extract	VERB
admet-2334	154	22	from	from	ADP
admet-2334	154	23	the	the	DET
admet-2334	154	24	analysis	analysis	NOUN
admet-2334	154	25	of	of	ADP
admet-2334	154	26	nuclear	nuclear	ADJ
admet-2334	154	27	overhauser	overhauser	NOUN
admet-2334	154	28	effects	effect	NOUN
admet-2334	154	29	(	(	PUNCT
admet-2334	154	30	noe	noe	NUM
admet-2334	154	31	)	)	PUNCT
admet-2334	154	32	and	and	CCONJ
admet-2334	154	33	proton	proton	NOUN
admet-2334	154	34	coupling	coupling	NOUN
admet-2334	154	35	constants	constant	NOUN
admet-2334	154	36	(	(	PUNCT
admet-2334	154	37	j	j	PROPN
admet-2334	154	38	coupling	coupling	NOUN
admet-2334	154	39	)	)	PUNCT
admet-2334	154	40	.	.	PUNCT
admet-2334	155	1	noe	noe	PROPN
admet-2334	155	2	and	and	CCONJ
admet-2334	155	3	j	j	PROPN
admet-2334	155	4	coupling	couple	VERB
admet-2334	155	5	data	datum	NOUN
admet-2334	155	6	form	form	VERB
admet-2334	155	7	the	the	DET
admet-2334	155	8	basis	basis	NOUN
admet-2334	155	9	for	for	ADP
admet-2334	155	10	the	the	DET
admet-2334	155	11	nmr	nmr	NOUN
admet-2334	155	12	analysis	analysis	NOUN
admet-2334	155	13	of	of	ADP
admet-2334	155	14	molecular	molecular	ADJ
admet-2334	155	15	flexibility	flexibility	NOUN
admet-2334	155	16	in	in	ADP
admet-2334	155	17	solution	solution	NOUN
admet-2334	155	18	(	(	PUNCT
admet-2334	155	19	namfis	namfis	ADV
admet-2334	155	20	,	,	PUNCT
admet-2334	155	21	a	a	DET
admet-2334	155	22	widely	widely	ADV
admet-2334	155	23	used	use	VERB
admet-2334	155	24	nmr	nmr	NOUN
admet-2334	155	25	data	datum	NOUN
admet-2334	155	26	analysis	analysis	NOUN
admet-2334	155	27	method	method	NOUN
admet-2334	155	28	)	)	PUNCT
admet-2334	155	29	.	.	PUNCT
admet-2334	156	1	through	through	ADP
admet-2334	156	2	namfis	namfis	NOUN
admet-2334	156	3	,	,	PUNCT
admet-2334	156	4	the	the	DET
admet-2334	156	5	nmr	nmr	NOUN
admet-2334	156	6	-	-	PUNCT
admet-2334	156	7	derived	derive	VERB
admet-2334	156	8	constraints	constraint	NOUN
admet-2334	156	9	are	be	AUX
admet-2334	156	10	fitted	fit	VERB
admet-2334	156	11	with	with	ADP
admet-2334	156	12	a	a	DET
admet-2334	156	13	series	series	NOUN
admet-2334	156	14	of	of	ADP
admet-2334	156	15	computationally	computationally	ADV
admet-2334	156	16	generated	generate	VERB
admet-2334	156	17	conformations	conformation	NOUN
admet-2334	156	18	,	,	PUNCT
admet-2334	156	19	allowing	allow	VERB
admet-2334	156	20	the	the	DET
admet-2334	156	21	extraction	extraction	NOUN
admet-2334	156	22	of	of	ADP
admet-2334	156	23	relative	relative	ADJ
admet-2334	156	24	population	population	NOUN
admet-2334	156	25	distributions	distribution	NOUN
admet-2334	156	26	in	in	ADP
admet-2334	156	27	solution	solution	NOUN
admet-2334	156	28	[	[	X
admet-2334	156	29	39	39	NUM
admet-2334	156	30	]	]	PUNCT
admet-2334	156	31	.	.	PUNCT
admet-2334	157	1	this	this	DET
admet-2334	157	2	strategy	strategy	NOUN
admet-2334	157	3	has	have	VERB
admet-2334	157	4	the	the	DET
admet-2334	157	5	advantage	advantage	NOUN
admet-2334	157	6	of	of	ADP
admet-2334	157	7	focusing	focus	VERB
admet-2334	157	8	on	on	ADP
admet-2334	157	9	actual	actual	ADJ
admet-2334	157	10	solution	solution	NOUN
admet-2334	157	11	conformers	conformer	NOUN
admet-2334	157	12	,	,	PUNCT
admet-2334	157	13	but	but	CCONJ
admet-2334	157	14	it	it	PRON
admet-2334	157	15	is	be	AUX
admet-2334	157	16	time	time	NOUN
admet-2334	157	17	-	-	PUNCT
admet-2334	157	18	consuming	consume	VERB
admet-2334	157	19	,	,	PUNCT
admet-2334	157	20	suffers	suffer	VERB
admet-2334	157	21	from	from	ADP
admet-2334	157	22	solubility	solubility	NOUN
admet-2334	157	23	issues	issue	NOUN
admet-2334	157	24	,	,	PUNCT
admet-2334	157	25	and	and	CCONJ
admet-2334	157	26	,	,	PUNCT
admet-2334	157	27	in	in	ADP
admet-2334	157	28	some	some	DET
admet-2334	157	29	cases	case	NOUN
admet-2334	157	30	,	,	PUNCT
admet-2334	157	31	overfitting	overfitte	VERB
admet-2334	157	32	can	can	AUX
admet-2334	157	33	bias	bias	VERB
admet-2334	157	34	the	the	DET
admet-2334	157	35	results	result	NOUN
admet-2334	157	36	and	and	CCONJ
admet-2334	157	37	require	require	VERB
admet-2334	157	38	skilled	skilled	ADJ
admet-2334	157	39	training	training	NOUN
admet-2334	157	40	,	,	PUNCT
admet-2334	157	41	making	make	VERB
admet-2334	157	42	it	it	PRON
admet-2334	157	43	inappropriate	inappropriate	ADJ
admet-2334	157	44	for	for	ADP
admet-2334	157	45	early	early	ADJ
admet-2334	157	46	drug	drug	NOUN
admet-2334	157	47	discovery	discovery	NOUN
admet-2334	157	48	.	.	PUNCT
admet-2334	158	1	two	two	NUM
admet-2334	158	2	hplc	hplc	NOUN
admet-2334	158	3	methods	method	NOUN
admet-2334	158	4	have	have	AUX
admet-2334	158	5	been	be	AUX
admet-2334	158	6	described	describe	VERB
admet-2334	158	7	up	up	ADP
admet-2334	158	8	to	to	ADP
admet-2334	158	9	date	date	NOUN
admet-2334	158	10	to	to	PART
admet-2334	158	11	assess	assess	VERB
admet-2334	158	12	chameleonicity	chameleonicity	NOUN
admet-2334	158	13	(	(	PUNCT
admet-2334	158	14	figure	figure	NOUN
admet-2334	158	15	5	5	NUM
admet-2334	158	16	):	):	PUNCT
admet-2334	158	17	chamelogd	chamelogd	NOUN
admet-2334	158	18	and	and	CCONJ
admet-2334	158	19	chamelogk	chamelogk	ADJ
admet-2334	158	20	.	.	PUNCT
admet-2334	159	1	chamelogd	chamelogd	NOUN
admet-2334	159	2	(	(	PUNCT
admet-2334	159	3	figure	figure	NOUN
admet-2334	159	4	5a	5a	NUM
admet-2334	159	5	)	)	PUNCT
admet-2334	159	6	is	be	AUX
admet-2334	159	7	the	the	DET
admet-2334	159	8	difference	difference	NOUN
admet-2334	159	9	between	between	ADP
admet-2334	159	10	two	two	NUM
admet-2334	159	11	descriptors	descriptor	NOUN
admet-2334	159	12	elogd	elogd	ADJ
admet-2334	159	13	and	and	CCONJ
admet-2334	159	14	brlogd	brlogd	NOUN
admet-2334	159	15	,	,	PUNCT
admet-2334	159	16	both	both	DET
admet-2334	159	17	surrogates	surrogate	NOUN
admet-2334	159	18	of	of	ADP
admet-2334	159	19	log	log	NOUN
admet-2334	159	20	doct	doct	PROPN
admet-2334	160	1	[	[	X
admet-2334	160	2	23	23	NUM
admet-2334	160	3	]	]	PUNCT
admet-2334	160	4	.	.	PUNCT
admet-2334	161	1	since	since	SCONJ
admet-2334	161	2	elogd	elogd	ADJ
admet-2334	161	3	and	and	CCONJ
admet-2334	161	4	brlogd	brlogd	NOUN
admet-2334	161	5	are	be	AUX
admet-2334	161	6	obtained	obtain	VERB
admet-2334	161	7	in	in	ADP
admet-2334	161	8	two	two	NUM
admet-2334	161	9	different	different	ADJ
admet-2334	161	10	environments	environment	NOUN
admet-2334	161	11	,	,	PUNCT
admet-2334	161	12	their	their	PRON
admet-2334	161	13	difference	difference	NOUN
admet-2334	161	14	,	,	PUNCT
admet-2334	161	15	if	if	SCONJ
admet-2334	161	16	any	any	PRON
admet-2334	161	17	,	,	PUNCT
admet-2334	161	18	is	be	AUX
admet-2334	161	19	related	relate	VERB
admet-2334	161	20	to	to	ADP
admet-2334	161	21	chameleonicity	chameleonicity	NOUN
admet-2334	161	22	.	.	PUNCT
admet-2334	162	1	figure	figure	NOUN
admet-2334	162	2	5	5	NUM
admet-2334	162	3	.	.	PUNCT
admet-2334	162	4	chameleonicity	chameleonicity	NOUN
admet-2334	162	5	descriptors	descriptor	NOUN
admet-2334	162	6	(	(	PUNCT
admet-2334	162	7	a	a	X
admet-2334	162	8	)	)	PUNCT
admet-2334	162	9	chamelogd	chamelogd	NOUN
admet-2334	162	10	for	for	ADP
admet-2334	162	11	griseofulvin	griseofulvin	NOUN
admet-2334	162	12	(	(	PUNCT
admet-2334	162	13	yellow	yellow	ADJ
admet-2334	162	14	bars	bar	NOUN
admet-2334	162	15	,	,	PUNCT
admet-2334	162	16	a	a	DET
admet-2334	162	17	nonchameleonic	nonchameleonic	ADJ
admet-2334	162	18	drug	drug	NOUN
admet-2334	162	19	)	)	PUNCT
admet-2334	162	20	and	and	CCONJ
admet-2334	162	21	ritonavir	ritonavir	PRON
admet-2334	162	22	(	(	PUNCT
admet-2334	162	23	blue	blue	ADJ
admet-2334	162	24	bars	bar	NOUN
admet-2334	162	25	,	,	PUNCT
admet-2334	162	26	a	a	DET
admet-2334	162	27	chameleonic	chameleonic	ADJ
admet-2334	162	28	drug	drug	NOUN
admet-2334	162	29	)	)	PUNCT
admet-2334	162	30	and	and	CCONJ
admet-2334	162	31	(	(	PUNCT
admet-2334	162	32	b	b	X
admet-2334	162	33	)	)	PUNCT
admet-2334	162	34	chamelogk	chamelogk	ADJ
admet-2334	162	35	plots	plot	NOUN
admet-2334	162	36	of	of	ADP
admet-2334	162	37	cyclosporin	cyclosporin	NOUN
admet-2334	162	38	(	(	PUNCT
admet-2334	162	39	csa	csa	PROPN
admet-2334	162	40	,	,	PUNCT
admet-2334	162	41	bro5	bro5	PROPN
admet-2334	162	42	,	,	PUNCT
admet-2334	162	43	blue	blue	ADJ
admet-2334	162	44	triangles	triangle	NOUN
admet-2334	162	45	)	)	PUNCT
admet-2334	162	46	and	and	CCONJ
admet-2334	162	47	acetophenone	acetophenone	NOUN
admet-2334	162	48	(	(	PUNCT
admet-2334	162	49	ro5	ro5	ADJ
admet-2334	162	50	compound	compound	NOUN
admet-2334	162	51	,	,	PUNCT
admet-2334	162	52	gray	gray	ADJ
admet-2334	162	53	circles	circle	NOUN
admet-2334	162	54	)	)	PUNCT
admet-2334	162	55	;	;	PUNCT
admet-2334	163	1	exp	exp	NOUN
admet-2334	163	2	.	.	PROPN
admet-2334	164	1	log	log	PROPN
admet-2334	164	2	k	k	NOUN
admet-2334	164	3	'	'	PART
admet-2334	164	4	100	100	NUM
admet-2334	164	5	plrp	plrp	NOUN
admet-2334	164	6	-	-	PUNCT
admet-2334	164	7	s	s	NOUN
admet-2334	164	8	and	and	CCONJ
admet-2334	164	9	ext	ext	NOUN
admet-2334	164	10	.	.	PUNCT
admet-2334	165	1	log	log	VERB
admet-2334	165	2	k	k	NOUN
admet-2334	165	3	’	'	PUNCT
admet-2334	165	4	100	100	NUM
admet-2334	165	5	plrp	plrp	NOUN
admet-2334	165	6	-	-	PUNCT
admet-2334	165	7	s	s	NOUN
admet-2334	165	8	values	value	NOUN
admet-2334	165	9	are	be	AUX
admet-2334	165	10	presented	present	VERB
admet-2334	165	11	as	as	ADP
admet-2334	165	12	colored	color	VERB
admet-2334	165	13	symbols	symbol	NOUN
admet-2334	165	14	and	and	CCONJ
admet-2334	165	15	colored	colored	ADJ
admet-2334	165	16	crosses	crosse	NOUN
admet-2334	165	17	,	,	PUNCT
admet-2334	165	18	respectively	respectively	ADV
admet-2334	165	19	.	.	PUNCT
admet-2334	166	1	chamelogd	chamelogd	PROPN
admet-2334	166	2	represented	represent	VERB
admet-2334	166	3	the	the	DET
admet-2334	166	4	first	first	ADJ
admet-2334	166	5	hplc	hplc	NOUN
admet-2334	166	6	-	-	PUNCT
admet-2334	166	7	based	base	VERB
admet-2334	166	8	chameleonicity	chameleonicity	NOUN
admet-2334	166	9	descriptor	descriptor	NOUN
admet-2334	166	10	suitable	suitable	ADJ
admet-2334	166	11	for	for	ADP
admet-2334	166	12	high	high	ADJ
admet-2334	166	13	-	-	PUNCT
admet-2334	166	14	throughput	throughput	NOUN
admet-2334	166	15	(	(	PUNCT
admet-2334	166	16	ht	ht	NOUN
admet-2334	166	17	)	)	PUNCT
admet-2334	166	18	contexts	contexts	NOUN
admet-2334	166	19	.	.	PUNCT
admet-2334	167	1	however	however	ADV
admet-2334	167	2	,	,	PUNCT
admet-2334	167	3	its	its	PRON
admet-2334	167	4	practical	practical	ADJ
admet-2334	167	5	application	application	NOUN
admet-2334	167	6	is	be	AUX
admet-2334	167	7	complicated	complicate	VERB
admet-2334	167	8	by	by	ADP
admet-2334	167	9	the	the	DET
admet-2334	167	10	utilization	utilization	NOUN
admet-2334	167	11	of	of	ADP
admet-2334	167	12	two	two	NUM
admet-2334	167	13	distinct	distinct	ADJ
admet-2334	167	14	chromatographic	chromatographic	ADJ
admet-2334	167	15	systems	system	NOUN
admet-2334	167	16	.	.	PUNCT
admet-2334	168	1	therefore	therefore	ADV
admet-2334	168	2	,	,	PUNCT
admet-2334	168	3	we	we	PRON
admet-2334	168	4	recently	recently	ADV
admet-2334	168	5	implemented	implement	VERB
admet-2334	168	6	a	a	DET
admet-2334	168	7	chromatographic	chromatographic	ADJ
admet-2334	168	8	descriptor	descriptor	NOUN
admet-2334	168	9	,	,	PUNCT
admet-2334	168	10	chamelogk	chamelogk	ADJ
admet-2334	168	11	,	,	PUNCT
admet-2334	168	12	that	that	PRON
admet-2334	168	13	measures	measure	VERB
admet-2334	168	14	chameleonicity	chameleonicity	NOUN
admet-2334	168	15	in	in	ADP
admet-2334	168	16	a	a	DET
admet-2334	168	17	unique	unique	ADJ
admet-2334	168	18	and	and	CCONJ
admet-2334	168	19	dynamic	dynamic	ADJ
admet-2334	168	20	system	system	NOUN
admet-2334	168	21	[	[	X
admet-2334	168	22	40	40	NUM
admet-2334	168	23	]	]	PUNCT
admet-2334	168	24	.	.	PUNCT
admet-2334	169	1	to	to	PART
admet-2334	169	2	obtain	obtain	VERB
admet-2334	169	3	chamelogk	chamelogk	ADJ
admet-2334	169	4	(	(	PUNCT
admet-2334	169	5	figure	figure	NOUN
admet-2334	169	6	5b	5b	NUM
admet-2334	169	7	)	)	PUNCT
admet-2334	169	8	,	,	PUNCT
admet-2334	169	9	the	the	DET
admet-2334	169	10	first	first	ADJ
admet-2334	169	11	step	step	NOUN
admet-2334	169	12	involves	involve	VERB
admet-2334	169	13	the	the	DET
admet-2334	169	14	experimental	experimental	ADJ
admet-2334	169	15	determination	determination	NOUN
admet-2334	169	16	of	of	ADP
admet-2334	169	17	the	the	DET
admet-2334	169	18	capacity	capacity	NOUN
admet-2334	169	19	factor	factor	NOUN
admet-2334	169	20	(	(	PUNCT
admet-2334	169	21	log	log	NOUN
admet-2334	169	22	k	k	NOUN
admet-2334	169	23	'	'	PUNCT
admet-2334	169	24	plrp	plrp	NOUN
admet-2334	169	25	-	-	PUNCT
admet-2334	169	26	s	s	NOUN
admet-2334	169	27	)	)	PUNCT
admet-2334	169	28	at	at	ADP
admet-2334	169	29	50	50	NUM
admet-2334	169	30	,	,	PUNCT
admet-2334	169	31	60	60	NUM
admet-2334	169	32	,	,	PUNCT
admet-2334	169	33	and	and	CCONJ
admet-2334	169	34	70	70	NUM
admet-2334	169	35	%	%	NOUN
admet-2334	169	36	of	of	ADP
admet-2334	169	37	acetonitrile	acetonitrile	NOUN
admet-2334	169	38	.	.	PUNCT
admet-2334	170	1	then	then	ADV
admet-2334	170	2	,	,	PUNCT
admet-2334	170	3	the	the	DET
admet-2334	170	4	linear	linear	ADJ
admet-2334	170	5	correlation	correlation	NOUN
admet-2334	170	6	between	between	ADP
admet-2334	170	7	the	the	DET
admet-2334	170	8	log	log	NOUN
admet-2334	170	9	k	k	NOUN
admet-2334	170	10	'	'	PUNCT
admet-2334	170	11	plrp	plrp	NOUN
admet-2334	170	12	-	-	PUNCT
admet-2334	170	13	s	s	NOUN
admet-2334	170	14	and	and	CCONJ
admet-2334	170	15	the	the	DET
admet-2334	170	16	percentage	percentage	NOUN
admet-2334	170	17	of	of	ADP
admet-2334	170	18	mecn	mecn	NOUN
admet-2334	170	19	is	be	AUX
admet-2334	170	20	determined	determine	VERB
admet-2334	170	21	.	.	PUNCT
admet-2334	171	1	the	the	DET
admet-2334	171	2	equation	equation	NOUN
admet-2334	171	3	derived	derive	VERB
admet-2334	171	4	from	from	ADP
admet-2334	171	5	the	the	DET
admet-2334	171	6	linear	linear	ADJ
admet-2334	171	7	correlation	correlation	NOUN
admet-2334	171	8	is	be	AUX
admet-2334	171	9	then	then	ADV
admet-2334	171	10	applied	apply	VERB
admet-2334	171	11	to	to	PART
admet-2334	171	12	extrapolate	extrapolate	VERB
admet-2334	171	13	the	the	DET
admet-2334	171	14	capacity	capacity	NOUN
admet-2334	171	15	factor	factor	NOUN
admet-2334	171	16	at	at	ADP
admet-2334	171	17	100	100	NUM
admet-2334	171	18	%	%	NOUN
admet-2334	171	19	(	(	PUNCT
admet-2334	171	20	called	call	VERB
admet-2334	171	21	ext	ext	NOUN
admet-2334	171	22	.	.	PUNCT
admet-2334	172	1	log	log	VERB
admet-2334	172	2	k	k	NOUN
admet-2334	172	3	’	'	PUNCT
admet-2334	172	4	100	100	NUM
admet-2334	172	5	plrp	plrp	NOUN
admet-2334	172	6	-	-	PUNCT
admet-2334	172	7	s	s	NOUN
admet-2334	172	8	)	)	PUNCT
admet-2334	172	9	.	.	PUNCT
admet-2334	173	1	then	then	ADV
admet-2334	173	2	,	,	PUNCT
admet-2334	173	3	the	the	DET
admet-2334	173	4	experimental	experimental	ADJ
admet-2334	173	5	value	value	NOUN
admet-2334	173	6	at	at	ADP
admet-2334	173	7	100	100	NUM
admet-2334	173	8	%	%	NOUN
admet-2334	173	9	mecn	mecn	NOUN
admet-2334	173	10	is	be	AUX
admet-2334	173	11	measured	measure	VERB
admet-2334	173	12	(	(	PUNCT
admet-2334	173	13	named	name	VERB
admet-2334	173	14	exp	exp	NOUN
admet-2334	173	15	.	.	PUNCT
admet-2334	174	1	log	log	PROPN
admet-2334	174	2	k	k	NOUN
admet-2334	174	3	’	'	PUNCT
admet-2334	174	4	100	100	NUM
admet-2334	174	5	plrp	plrp	NOUN
admet-2334	174	6	-	-	PUNCT
admet-2334	174	7	s	s	NOUN
admet-2334	174	8	)	)	PUNCT
admet-2334	174	9	and	and	CCONJ
admet-2334	174	10	the	the	DET
admet-2334	174	11	difference	difference	NOUN
admet-2334	174	12	with	with	ADP
admet-2334	174	13	the	the	DET
admet-2334	174	14	extrapolated	extrapolated	ADJ
admet-2334	174	15	value	value	NOUN
admet-2334	174	16	is	be	AUX
admet-2334	174	17	calculated	calculate	VERB
admet-2334	174	18	.	.	PUNCT
admet-2334	175	1	thus	thus	ADV
admet-2334	175	2	,	,	PUNCT
admet-2334	175	3	chamelogk	chamelogk	ADJ
admet-2334	175	4	is	be	AUX
admet-2334	175	5	defined	define	VERB
admet-2334	175	6	as	as	ADP
admet-2334	175	7	the	the	DET
admet-2334	175	8	capacity	capacity	NOUN
admet-2334	175	9	factor	factor	NOUN
admet-2334	175	10	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	175	11	d.	d.	PROPN
admet-2334	175	12	g.	g.	PROPN
admet-2334	175	13	jiménez	jiménez	PROPN
admet-2334	175	14	et	et	PROPN
admet-2334	175	15	al	al	PROPN
admet-2334	175	16	.	.	PROPN
admet-2334	175	17	admet	admet	PROPN
admet-2334	175	18	&	&	CCONJ
admet-2334	175	19	dmpk	dmpk	PROPN
admet-2334	175	20	12(5	12(5	NUM
admet-2334	175	21	)	)	PUNCT
admet-2334	175	22	(	(	PUNCT
admet-2334	175	23	2024	2024	NUM
admet-2334	175	24	)	)	PUNCT
admet-2334	175	25	721	721	NUM
admet-2334	175	26	-	-	SYM
admet-2334	175	27	736	736	NUM
admet-2334	175	28	728	728	NUM
admet-2334	175	29	difference	difference	NOUN
admet-2334	175	30	(	(	PUNCT
admet-2334	175	31	δ	δ	PROPN
admet-2334	175	32	log	log	VERB
admet-2334	175	33	k	k	NOUN
admet-2334	175	34	'	'	PUNCT
admet-2334	175	35	)	)	PUNCT
admet-2334	175	36	between	between	ADP
admet-2334	175	37	the	the	DET
admet-2334	175	38	experimental	experimental	ADJ
admet-2334	175	39	log	log	NOUN
admet-2334	175	40	k	k	X
admet-2334	175	41	'	'	PUNCT
admet-2334	175	42	measured	measure	VERB
admet-2334	175	43	at	at	ADP
admet-2334	175	44	100	100	NUM
admet-2334	175	45	%	%	NOUN
admet-2334	175	46	mecn	mecn	NOUN
admet-2334	175	47	(	(	PUNCT
admet-2334	175	48	exp	exp	NOUN
admet-2334	175	49	.	.	PUNCT
admet-2334	175	50	log	log	PROPN
admet-2334	175	51	k	k	NOUN
admet-2334	175	52	'	'	PART
admet-2334	175	53	100	100	NUM
admet-2334	175	54	)	)	PUNCT
admet-2334	175	55	and	and	CCONJ
admet-2334	175	56	the	the	DET
admet-2334	175	57	extrapolated	extrapolated	ADJ
admet-2334	175	58	value	value	NOUN
admet-2334	175	59	(	(	PUNCT
admet-2334	175	60	ext	ext	NOUN
admet-2334	175	61	.	.	PUNCT
admet-2334	176	1	log	log	PROPN
admet-2334	176	2	k	k	NOUN
admet-2334	176	3	’	'	PUNCT
admet-2334	176	4	100	100	NUM
admet-2334	176	5	)	)	PUNCT
admet-2334	176	6	,	,	PUNCT
admet-2334	176	7	as	as	SCONJ
admet-2334	176	8	shown	show	VERB
admet-2334	176	9	by	by	ADP
admet-2334	176	10	equation	equation	NOUN
admet-2334	176	11	2	2	NUM
admet-2334	176	12	and	and	CCONJ
admet-2334	176	13	figure	figure	NOUN
admet-2334	176	14	5b	5b	NUM
admet-2334	176	15	.	.	PUNCT
admet-2334	177	1	chame	chame	PROPN
admet-2334	177	2	log	log	VERB
admet-2334	177	3	k	k	PROPN
admet-2334	177	4	=	=	PUNCT
admet-2334	177	5	exp	exp	PROPN
admet-2334	177	6	.	.	PROPN
admet-2334	178	1	log	log	PROPN
admet-2334	178	2	k′	k′	PROPN
admet-2334	178	3	100	100	NUM
admet-2334	178	4	−	−	PROPN
admet-2334	178	5	ext	ext	NOUN
admet-2334	178	6	.	.	PUNCT
admet-2334	179	1	log	log	PROPN
admet-2334	179	2	k′	k′	PROPN
admet-2334	179	3	100	100	NUM
admet-2334	179	4	(	(	PUNCT
admet-2334	179	5	2	2	X
admet-2334	179	6	)	)	PUNCT
admet-2334	179	7	experimental	experimental	ADJ
admet-2334	179	8	determination	determination	NOUN
admet-2334	179	9	of	of	ADP
admet-2334	179	10	the	the	DET
admet-2334	179	11	aforementioned	aforementioned	ADJ
admet-2334	179	12	physicochemical	physicochemical	ADJ
admet-2334	179	13	descriptors	descriptor	NOUN
admet-2334	179	14	is	be	AUX
admet-2334	179	15	a	a	DET
admet-2334	179	16	crucial	crucial	ADJ
admet-2334	179	17	step	step	NOUN
admet-2334	179	18	in	in	ADP
admet-2334	179	19	lead	lead	NOUN
admet-2334	179	20	prioritization	prioritization	NOUN
admet-2334	179	21	and	and	CCONJ
admet-2334	179	22	optimization	optimization	NOUN
admet-2334	179	23	.	.	PUNCT
admet-2334	180	1	however	however	ADV
admet-2334	180	2	,	,	PUNCT
admet-2334	180	3	it	it	PRON
admet-2334	180	4	is	be	AUX
admet-2334	180	5	also	also	ADV
admet-2334	180	6	of	of	ADP
admet-2334	180	7	great	great	ADJ
admet-2334	180	8	importance	importance	NOUN
admet-2334	180	9	to	to	PART
admet-2334	180	10	be	be	AUX
admet-2334	180	11	able	able	ADJ
admet-2334	180	12	to	to	PART
admet-2334	180	13	predict	predict	VERB
admet-2334	180	14	the	the	DET
admet-2334	180	15	chameleonnicity	chameleonnicity	NOUN
admet-2334	180	16	of	of	ADP
admet-2334	180	17	a	a	DET
admet-2334	180	18	molecule	molecule	NOUN
admet-2334	180	19	in	in	ADP
admet-2334	180	20	the	the	DET
admet-2334	180	21	early	early	ADJ
admet-2334	180	22	stage	stage	NOUN
admet-2334	180	23	of	of	ADP
admet-2334	180	24	drug	drug	NOUN
admet-2334	180	25	discovery	discovery	NOUN
admet-2334	180	26	,	,	PUNCT
admet-2334	180	27	potentially	potentially	ADV
admet-2334	180	28	even	even	ADV
admet-2334	180	29	before	before	ADP
admet-2334	180	30	synthesis	synthesis	NOUN
admet-2334	180	31	.	.	PUNCT
admet-2334	181	1	according	accord	VERB
admet-2334	181	2	to	to	ADP
admet-2334	181	3	kihlberg	kihlberg	PROPN
admet-2334	181	4	[	[	X
admet-2334	181	5	41	41	NUM
admet-2334	181	6	]	]	PUNCT
admet-2334	181	7	and	and	CCONJ
admet-2334	181	8	others	other	NOUN
admet-2334	182	1	[	[	X
admet-2334	182	2	38	38	NUM
admet-2334	182	3	]	]	PUNCT
admet-2334	182	4	,	,	PUNCT
admet-2334	182	5	a	a	DET
admet-2334	182	6	compound	compound	NOUN
admet-2334	182	7	to	to	PART
admet-2334	182	8	display	display	VERB
admet-2334	182	9	chameleonic	chameleonic	ADJ
admet-2334	182	10	properties	property	NOUN
admet-2334	182	11	(	(	PUNCT
admet-2334	182	12	mainly	mainly	ADV
admet-2334	182	13	imhbdriven	imhbdriven	NUM
admet-2334	182	14	)	)	PUNCT
admet-2334	182	15	should	should	AUX
admet-2334	182	16	fulfill	fulfill	VERB
admet-2334	182	17	two	two	NUM
admet-2334	182	18	requirements	requirement	NOUN
admet-2334	182	19	:	:	PUNCT
admet-2334	182	20	a	a	X
admet-2334	182	21	)	)	PUNCT
admet-2334	182	22	to	to	PART
admet-2334	182	23	display	display	VERB
admet-2334	182	24	a	a	DET
admet-2334	182	25	broad	broad	ADJ
admet-2334	182	26	molecular	molecular	ADJ
admet-2334	182	27	property	property	NOUN
admet-2334	182	28	space	space	NOUN
admet-2334	182	29	and	and	CCONJ
admet-2334	182	30	b	b	X
admet-2334	182	31	)	)	PUNCT
admet-2334	182	32	provide	provide	VERB
admet-2334	182	33	privileged	privileged	ADJ
admet-2334	182	34	polarity	polarity	NOUN
admet-2334	182	35	regions	region	NOUN
admet-2334	182	36	in	in	ADP
admet-2334	182	37	an	an	DET
admet-2334	182	38	environment	environment	NOUN
admet-2334	182	39	-	-	PUNCT
admet-2334	182	40	dependent	dependent	ADJ
admet-2334	182	41	manner	manner	NOUN
admet-2334	182	42	(	(	PUNCT
admet-2334	182	43	highest	high	ADJ
admet-2334	182	44	polarity	polarity	NOUN
admet-2334	182	45	in	in	ADP
admet-2334	182	46	polar	polar	ADJ
admet-2334	182	47	environments	environment	NOUN
admet-2334	182	48	and	and	CCONJ
admet-2334	182	49	minimal	minimal	ADJ
admet-2334	182	50	in	in	ADP
admet-2334	182	51	nonpolar	nonpolar	ADJ
admet-2334	182	52	ones	one	NOUN
admet-2334	182	53	)	)	PUNCT
admet-2334	182	54	.	.	PUNCT
admet-2334	183	1	based	base	VERB
admet-2334	183	2	on	on	ADP
admet-2334	183	3	these	these	DET
admet-2334	183	4	observations	observation	NOUN
admet-2334	183	5	,	,	PUNCT
admet-2334	183	6	it	it	PRON
admet-2334	183	7	is	be	AUX
admet-2334	183	8	clear	clear	ADJ
admet-2334	183	9	that	that	SCONJ
admet-2334	183	10	chameleonicity	chameleonicity	NOUN
admet-2334	183	11	can	can	AUX
admet-2334	183	12	not	not	PART
admet-2334	183	13	be	be	AUX
admet-2334	183	14	predicted	predict	VERB
admet-2334	183	15	using	use	VERB
admet-2334	183	16	simple	simple	ADJ
admet-2334	183	17	2d	2d	NUM
admet-2334	183	18	descriptors	descriptor	NOUN
admet-2334	183	19	such	such	ADJ
admet-2334	183	20	as	as	ADP
admet-2334	183	21	hbd	hbd	PROPN
admet-2334	183	22	,	,	PUNCT
admet-2334	183	23	hba	hba	PROPN
admet-2334	183	24	,	,	PUNCT
admet-2334	183	25	tpsa	tpsa	NOUN
admet-2334	183	26	,	,	PUNCT
admet-2334	183	27	and	and	CCONJ
admet-2334	183	28	phi	phi	NOUN
admet-2334	183	29	.	.	PUNCT
admet-2334	184	1	instead	instead	ADV
admet-2334	184	2	,	,	PUNCT
admet-2334	184	3	it	it	PRON
admet-2334	184	4	requires	require	VERB
admet-2334	184	5	a	a	PRON
admet-2334	184	6	)	)	PUNCT
admet-2334	184	7	generating	generate	VERB
admet-2334	184	8	an	an	DET
admet-2334	184	9	ensemble	ensemble	NOUN
admet-2334	184	10	of	of	ADP
admet-2334	184	11	conformers	conformer	NOUN
admet-2334	184	12	and	and	CCONJ
admet-2334	184	13	b	b	NOUN
admet-2334	184	14	)	)	PUNCT
admet-2334	184	15	characterizing	characterize	VERB
admet-2334	184	16	them	they	PRON
admet-2334	184	17	with	with	ADP
admet-2334	184	18	appropriate	appropriate	ADJ
admet-2334	184	19	descriptors	descriptor	NOUN
admet-2334	184	20	.	.	PUNCT
admet-2334	185	1	in	in	ADP
admet-2334	185	2	previous	previous	ADJ
admet-2334	185	3	papers	paper	NOUN
admet-2334	185	4	,	,	PUNCT
admet-2334	185	5	we	we	PRON
admet-2334	185	6	first	first	ADV
admet-2334	185	7	used	use	VERB
admet-2334	185	8	conformational	conformational	ADJ
admet-2334	185	9	sampling	sampling	NOUN
admet-2334	185	10	(	(	PUNCT
admet-2334	185	11	cs	cs	ADJ
admet-2334	185	12	)	)	PUNCT
admet-2334	185	13	strategies	strategy	NOUN
admet-2334	185	14	to	to	PART
admet-2334	185	15	obtain	obtain	VERB
admet-2334	185	16	an	an	DET
admet-2334	185	17	ensemble	ensemble	NOUN
admet-2334	185	18	of	of	ADP
admet-2334	185	19	conformers	conformer	NOUN
admet-2334	185	20	with	with	ADP
admet-2334	185	21	their	their	PRON
admet-2334	185	22	associated	associated	ADJ
admet-2334	185	23	energies	energy	NOUN
admet-2334	185	24	.	.	PUNCT
admet-2334	186	1	once	once	SCONJ
admet-2334	186	2	the	the	DET
admet-2334	186	3	conformer	conformer	NOUN
admet-2334	186	4	populations	population	NOUN
admet-2334	186	5	have	have	AUX
admet-2334	186	6	been	be	AUX
admet-2334	186	7	obtained	obtain	VERB
admet-2334	186	8	,	,	PUNCT
admet-2334	186	9	we	we	PRON
admet-2334	186	10	monitored	monitor	VERB
admet-2334	186	11	conformer	conformer	NOUN
admet-2334	186	12	properties	property	NOUN
admet-2334	186	13	by	by	ADP
admet-2334	186	14	calculating	calculate	VERB
admet-2334	186	15	polarity	polarity	NOUN
admet-2334	186	16	(	(	PUNCT
admet-2334	186	17	computationally	computationally	ADV
admet-2334	186	18	measured	measure	VERB
admet-2334	186	19	by	by	ADP
admet-2334	186	20	3d	3d	PROPN
admet-2334	186	21	psa	psa	NOUN
admet-2334	186	22	)	)	PUNCT
admet-2334	186	23	and	and	CCONJ
admet-2334	186	24	spherical	spherical	ADJ
admet-2334	186	25	shape	shape	NOUN
admet-2334	186	26	(	(	PUNCT
admet-2334	186	27	measured	measure	VERB
admet-2334	186	28	with	with	ADP
admet-2334	186	29	a	a	DET
admet-2334	186	30	variation	variation	NOUN
admet-2334	186	31	of	of	ADP
admet-2334	186	32	rgyr	rgyr	NOUN
admet-2334	186	33	)	)	PUNCT
admet-2334	186	34	.	.	PUNCT
admet-2334	187	1	then	then	ADV
admet-2334	187	2	,	,	PUNCT
admet-2334	187	3	we	we	PRON
admet-2334	187	4	plot	plot	VERB
admet-2334	187	5	rgyr	rgyr	NOUN
admet-2334	187	6	vs.	vs.	ADP
admet-2334	187	7	3d	3d	PROPN
admet-2334	187	8	psa	psa	NOUN
admet-2334	187	9	,	,	PUNCT
admet-2334	187	10	as	as	SCONJ
admet-2334	187	11	schematically	schematically	NOUN
admet-2334	187	12	summarized	summarize	VERB
admet-2334	187	13	in	in	ADP
admet-2334	187	14	figure	figure	NOUN
admet-2334	187	15	6	6	NUM
admet-2334	187	16	.	.	PUNCT
admet-2334	187	17	figure	figure	VERB
admet-2334	187	18	6	6	NUM
admet-2334	187	19	.	.	PUNCT
admet-2334	187	20	chameleonicity	chameleonicity	NOUN
admet-2334	187	21	prediction	prediction	NOUN
admet-2334	187	22	as	as	SCONJ
admet-2334	187	23	obtained	obtain	VERB
admet-2334	187	24	from	from	ADP
admet-2334	187	25	the	the	DET
admet-2334	187	26	3d	3d	PROPN
admet-2334	187	27	psa	psa	NOUN
admet-2334	187	28	vs.	vs.	ADP
admet-2334	187	29	rgyr	rgyr	PROPN
admet-2334	187	30	plot	plot	PROPN
admet-2334	187	31	:	:	PUNCT
admet-2334	188	1	conformers	conformer	NOUN
admet-2334	188	2	(	(	PUNCT
admet-2334	188	3	dots	dot	NOUN
admet-2334	188	4	)	)	PUNCT
admet-2334	188	5	obtained	obtain	VERB
admet-2334	188	6	from	from	ADP
admet-2334	188	7	cs	cs	PROPN
admet-2334	188	8	are	be	AUX
admet-2334	188	9	coloured	colour	VERB
admet-2334	188	10	according	accord	VERB
admet-2334	188	11	to	to	ADP
admet-2334	188	12	the	the	DET
admet-2334	188	13	environment	environment	NOUN
admet-2334	188	14	in	in	ADP
admet-2334	188	15	which	which	PRON
admet-2334	188	16	they	they	PRON
admet-2334	188	17	have	have	AUX
admet-2334	188	18	been	be	AUX
admet-2334	188	19	built	build	VERB
admet-2334	188	20	(	(	PUNCT
admet-2334	188	21	blue	blue	ADJ
admet-2334	188	22	water	water	NOUN
admet-2334	188	23	,	,	PUNCT
admet-2334	188	24	orange	orange	ADJ
admet-2334	188	25	nonpolar	nonpolar	ADJ
admet-2334	188	26	media	medium	NOUN
admet-2334	188	27	)	)	PUNCT
admet-2334	188	28	and	and	CCONJ
admet-2334	188	29	the	the	DET
admet-2334	188	30	minimum	minimum	ADJ
admet-2334	188	31	energy	energy	NOUN
admet-2334	188	32	conformers	conformer	NOUN
admet-2334	188	33	(	(	PUNCT
admet-2334	188	34	triangles	triangle	NOUN
admet-2334	188	35	)	)	PUNCT
admet-2334	188	36	as	as	ADV
admet-2334	188	37	well	well	ADV
admet-2334	188	38	(	(	PUNCT
admet-2334	188	39	light	light	ADJ
admet-2334	188	40	blue	blue	ADJ
admet-2334	188	41	water	water	NOUN
admet-2334	188	42	,	,	PUNCT
admet-2334	188	43	yellow	yellow	ADJ
admet-2334	188	44	nonpolar	nonpolar	ADJ
admet-2334	188	45	media	medium	NOUN
admet-2334	188	46	)	)	PUNCT
admet-2334	188	47	.	.	PUNCT
admet-2334	189	1	a	a	X
admet-2334	189	2	)	)	PUNCT
admet-2334	189	3	a	a	DET
admet-2334	189	4	compound	compound	NOUN
admet-2334	189	5	with	with	ADP
admet-2334	189	6	chameleonic	chameleonic	ADJ
admet-2334	189	7	properties	property	NOUN
admet-2334	189	8	and	and	CCONJ
admet-2334	189	9	b	b	X
admet-2334	189	10	)	)	PUNCT
admet-2334	189	11	a	a	DET
admet-2334	189	12	non	non	ADJ
admet-2334	189	13	-	-	ADJ
admet-2334	189	14	chameleonic	chameleonic	ADJ
admet-2334	189	15	compound	compound	NOUN
admet-2334	189	16	.	.	PUNCT
admet-2334	190	1	figure	figure	NOUN
admet-2334	190	2	6a	6a	NOUN
admet-2334	190	3	describes	describe	VERB
admet-2334	190	4	the	the	DET
admet-2334	190	5	behavior	behavior	NOUN
admet-2334	190	6	of	of	ADP
admet-2334	190	7	a	a	DET
admet-2334	190	8	compound	compound	NOUN
admet-2334	190	9	showing	show	VERB
admet-2334	190	10	chameleonic	chameleonic	ADJ
admet-2334	190	11	properties	property	NOUN
admet-2334	190	12	:	:	PUNCT
admet-2334	190	13	the	the	DET
admet-2334	190	14	orange	orange	PROPN
admet-2334	190	15	dots	dot	NOUN
admet-2334	190	16	are	be	AUX
admet-2334	190	17	the	the	DET
admet-2334	190	18	conformers	conformer	NOUN
admet-2334	190	19	obtained	obtain	VERB
admet-2334	190	20	in	in	ADP
admet-2334	190	21	the	the	DET
admet-2334	190	22	nonpolar	nonpolar	ADJ
admet-2334	190	23	environments	environment	NOUN
admet-2334	190	24	,	,	PUNCT
admet-2334	190	25	whereas	whereas	SCONJ
admet-2334	190	26	the	the	DET
admet-2334	190	27	blue	blue	ADJ
admet-2334	190	28	dots	dot	NOUN
admet-2334	190	29	are	be	AUX
admet-2334	190	30	those	those	PRON
admet-2334	190	31	extracted	extract	VERB
admet-2334	190	32	from	from	ADP
admet-2334	190	33	the	the	DET
admet-2334	190	34	cs	cs	PROPN
admet-2334	190	35	run	run	NOUN
admet-2334	190	36	in	in	ADP
admet-2334	190	37	water	water	NOUN
admet-2334	190	38	.	.	PUNCT
admet-2334	191	1	according	accord	VERB
admet-2334	191	2	to	to	ADP
admet-2334	191	3	the	the	DET
admet-2334	191	4	definition	definition	NOUN
admet-2334	191	5	of	of	ADP
admet-2334	191	6	chameleonicity	chameleonicity	NOUN
admet-2334	191	7	,	,	PUNCT
admet-2334	191	8	the	the	DET
admet-2334	191	9	orange	orange	PROPN
admet-2334	191	10	dots	dot	NOUN
admet-2334	191	11	should	should	AUX
admet-2334	191	12	show	show	VERB
admet-2334	191	13	lower	low	ADJ
admet-2334	191	14	polarity	polarity	NOUN
admet-2334	191	15	than	than	ADP
admet-2334	191	16	the	the	DET
admet-2334	191	17	blue	blue	ADJ
admet-2334	191	18	dots	dot	NOUN
admet-2334	191	19	.	.	PUNCT
admet-2334	192	1	on	on	ADP
admet-2334	192	2	the	the	DET
admet-2334	192	3	other	other	ADJ
admet-2334	192	4	hand	hand	NOUN
admet-2334	192	5	,	,	PUNCT
admet-2334	192	6	figure	figure	NOUN
admet-2334	192	7	6b	6b	NOUN
admet-2334	192	8	,	,	PUNCT
admet-2334	192	9	representing	represent	VERB
admet-2334	192	10	a	a	DET
admet-2334	192	11	non	non	ADJ
admet-2334	192	12	-	-	ADJ
admet-2334	192	13	chameleonic	chameleonic	ADJ
admet-2334	192	14	behavior	behavior	NOUN
admet-2334	192	15	,	,	PUNCT
admet-2334	192	16	shows	show	VERB
admet-2334	192	17	that	that	SCONJ
admet-2334	192	18	no	no	DET
admet-2334	192	19	difference	difference	NOUN
admet-2334	192	20	can	can	AUX
admet-2334	192	21	be	be	AUX
admet-2334	192	22	monitored	monitor	VERB
admet-2334	192	23	by	by	ADP
admet-2334	192	24	the	the	DET
admet-2334	192	25	two	two	NUM
admet-2334	192	26	pools	pool	NOUN
admet-2334	192	27	of	of	ADP
admet-2334	192	28	conformers	conformer	NOUN
admet-2334	192	29	.	.	PUNCT
admet-2334	193	1	a	a	DET
admet-2334	193	2	similar	similar	ADJ
admet-2334	193	3	reasoning	reasoning	NOUN
admet-2334	193	4	holds	hold	VERB
admet-2334	193	5	for	for	ADP
admet-2334	193	6	the	the	DET
admet-2334	193	7	minimum	minimum	ADJ
admet-2334	193	8	energy	energy	NOUN
admet-2334	193	9	conformers	conformer	NOUN
admet-2334	193	10	(	(	PUNCT
admet-2334	193	11	mecs	mecs	PROPN
admet-2334	193	12	)	)	PUNCT
admet-2334	193	13	(	(	PUNCT
admet-2334	193	14	triangles	triangle	NOUN
admet-2334	193	15	)	)	PUNCT
admet-2334	193	16	(	(	PUNCT
admet-2334	193	17	yellow	yellow	ADJ
admet-2334	193	18	and	and	CCONJ
admet-2334	193	19	blue	blue	ADJ
admet-2334	193	20	triangles	triangle	NOUN
admet-2334	193	21	,	,	PUNCT
admet-2334	193	22	respectively	respectively	ADV
admet-2334	193	23	)	)	PUNCT
admet-2334	193	24	.	.	PUNCT
admet-2334	194	1	however	however	ADV
admet-2334	194	2	,	,	PUNCT
admet-2334	194	3	chameleonicity	chameleonicity	NOUN
admet-2334	194	4	is	be	AUX
admet-2334	194	5	a	a	DET
admet-2334	194	6	property	property	NOUN
admet-2334	194	7	related	relate	VERB
admet-2334	194	8	to	to	ADP
admet-2334	194	9	the	the	DET
admet-2334	194	10	dynamic	dynamic	ADJ
admet-2334	194	11	behavior	behavior	NOUN
admet-2334	194	12	of	of	ADP
admet-2334	194	13	molecules	molecule	NOUN
admet-2334	194	14	,	,	PUNCT
admet-2334	194	15	which	which	PRON
admet-2334	194	16	is	be	AUX
admet-2334	194	17	best	well	ADV
admet-2334	194	18	captured	capture	VERB
admet-2334	194	19	by	by	ADP
admet-2334	194	20	considering	consider	VERB
admet-2334	194	21	the	the	DET
admet-2334	194	22	entire	entire	ADJ
admet-2334	194	23	pool	pool	NOUN
admet-2334	194	24	of	of	ADP
admet-2334	194	25	conformers	conformer	NOUN
admet-2334	194	26	generated	generate	VERB
admet-2334	194	27	in	in	ADP
admet-2334	194	28	the	the	DET
admet-2334	194	29	two	two	NUM
admet-2334	194	30	environments	environment	NOUN
admet-2334	194	31	.	.	PUNCT
admet-2334	195	1	for	for	ADP
admet-2334	195	2	this	this	DET
admet-2334	195	3	reason	reason	NOUN
admet-2334	195	4	,	,	PUNCT
admet-2334	195	5	in	in	ADP
admet-2334	195	6	some	some	DET
admet-2334	195	7	cases	case	NOUN
admet-2334	195	8	,	,	PUNCT
admet-2334	195	9	the	the	DET
admet-2334	195	10	combined	combined	ADJ
admet-2334	195	11	use	use	NOUN
admet-2334	195	12	of	of	ADP
admet-2334	195	13	cs	cs	ADJ
admet-2334	195	14	and	and	CCONJ
admet-2334	195	15	molecular	molecular	ADJ
admet-2334	195	16	dynamics	dynamic	NOUN
admet-2334	195	17	simulation	simulation	NOUN
admet-2334	195	18	is	be	AUX
admet-2334	195	19	suggested	suggest	VERB
admet-2334	195	20	[	[	X
admet-2334	195	21	42	42	NUM
admet-2334	195	22	]	]	PUNCT
admet-2334	195	23	.	.	PUNCT
admet-2334	196	1	case	case	NOUN
admet-2334	196	2	studies	study	NOUN
admet-2334	196	3	below	below	ADV
admet-2334	196	4	,	,	PUNCT
admet-2334	196	5	we	we	PRON
admet-2334	196	6	apply	apply	VERB
admet-2334	196	7	all	all	DET
admet-2334	196	8	the	the	DET
admet-2334	196	9	experimental	experimental	ADJ
admet-2334	196	10	and	and	CCONJ
admet-2334	196	11	computational	computational	ADJ
admet-2334	196	12	protocols	protocol	NOUN
admet-2334	196	13	described	describe	VERB
admet-2334	196	14	above	above	ADV
admet-2334	196	15	to	to	ADP
admet-2334	196	16	three	three	NUM
admet-2334	196	17	protacs	protac	NOUN
admet-2334	196	18	that	that	PRON
admet-2334	196	19	have	have	AUX
admet-2334	196	20	entered	enter	VERB
admet-2334	196	21	clinical	clinical	ADJ
admet-2334	196	22	trials	trial	NOUN
admet-2334	196	23	and	and	CCONJ
admet-2334	196	24	have	have	AUX
admet-2334	196	25	not	not	PART
admet-2334	196	26	yet	yet	ADV
admet-2334	196	27	been	be	AUX
admet-2334	196	28	studied	study	VERB
admet-2334	196	29	:	:	PUNCT
admet-2334	196	30	arv-110	arv-110	ADJ
admet-2334	196	31	,	,	PUNCT
admet-2334	196	32	arv-471	arv-471	NOUN
admet-2334	196	33	,	,	PUNCT
admet-2334	196	34	and	and	CCONJ
admet-2334	196	35	dt-2216	dt-2216	PROPN
admet-2334	196	36	(	(	PUNCT
admet-2334	196	37	chemical	chemical	NOUN
admet-2334	196	38	structure	structure	NOUN
admet-2334	196	39	in	in	ADP
admet-2334	196	40	figure	figure	NOUN
admet-2334	196	41	7	7	NUM
admet-2334	196	42	)	)	PUNCT
admet-2334	196	43	.	.	PUNCT
admet-2334	197	1	160	160	NUM
admet-2334	197	2	180	180	NUM
admet-2334	197	3	200	200	NUM
admet-2334	197	4	220	220	NUM
admet-2334	197	5	240	240	NUM
admet-2334	197	6	4	4	NUM
admet-2334	197	7	5	5	NUM
admet-2334	197	8	6	6	NUM
admet-2334	197	9	7	7	NUM
admet-2334	197	10	8	8	NUM
admet-2334	197	11	9	9	NUM
admet-2334	197	12	3d	3d	NUM
admet-2334	197	13	psa	psa	NOUN
admet-2334	197	14	rg	rg	PROPN
admet-2334	198	1	yr	yr	PROPN
admet-2334	198	2	160	160	NUM
admet-2334	198	3	180	180	NUM
admet-2334	198	4	200	200	NUM
admet-2334	198	5	220	220	NUM
admet-2334	198	6	240	240	NUM
admet-2334	198	7	4	4	NUM
admet-2334	198	8	5	5	NUM
admet-2334	198	9	6	6	NUM
admet-2334	198	10	7	7	NUM
admet-2334	198	11	8	8	NUM
admet-2334	198	12	9	9	NUM
admet-2334	198	13	3d	3d	NUM
admet-2334	198	14	psa	psa	NOUN
admet-2334	199	1	rg	rg	PROPN
admet-2334	199	2	yr	yr	NOUN
admet-2334	199	3	x	x	SYM
admet-2334	199	4	ba	ba	PROPN
admet-2334	199	5	160	160	NUM
admet-2334	199	6	180	180	NUM
admet-2334	199	7	200	200	NUM
admet-2334	199	8	220	220	NUM
admet-2334	199	9	240	240	NUM
admet-2334	199	10	4	4	NUM
admet-2334	199	11	5	5	NUM
admet-2334	199	12	6	6	NUM
admet-2334	199	13	7	7	NUM
admet-2334	199	14	8	8	NUM
admet-2334	199	15	9	9	NUM
admet-2334	199	16	3d	3d	NUM
admet-2334	199	17	psa	psa	NOUN
admet-2334	200	1	rg	rg	PROPN
admet-2334	200	2	yr	yr	PROPN
admet-2334	200	3	160	160	NUM
admet-2334	200	4	180	180	NUM
admet-2334	200	5	200	200	NUM
admet-2334	200	6	220	220	NUM
admet-2334	200	7	240	240	NUM
admet-2334	200	8	4	4	NUM
admet-2334	200	9	5	5	NUM
admet-2334	200	10	6	6	NUM
admet-2334	200	11	7	7	NUM
admet-2334	200	12	8	8	NUM
admet-2334	200	13	9	9	NUM
admet-2334	200	14	3d	3d	NUM
admet-2334	200	15	psa	psa	NOUN
admet-2334	200	16	rg	rg	PROPN
admet-2334	200	17	yr	yr	PROPN
admet-2334	200	18	admet	admet	PROPN
admet-2334	200	19	&	&	CCONJ
admet-2334	200	20	dmpk	dmpk	PROPN
admet-2334	200	21	12(5	12(5	NUM
admet-2334	200	22	)	)	PUNCT
admet-2334	200	23	(	(	PUNCT
admet-2334	200	24	2024	2024	NUM
admet-2334	200	25	)	)	PUNCT
admet-2334	200	26	721	721	NUM
admet-2334	200	27	-	-	NUM
admet-2334	200	28	736	736	NUM
admet-2334	200	29	designing	design	VERB
admet-2334	200	30	the	the	DET
admet-2334	200	31	next	next	ADJ
admet-2334	200	32	generation	generation	NOUN
admet-2334	200	33	of	of	ADP
admet-2334	200	34	oral	oral	ADJ
admet-2334	200	35	beyond	beyond	ADP
admet-2334	200	36	rule	rule	NOUN
admet-2334	200	37	of	of	ADP
admet-2334	200	38	five	five	NUM
admet-2334	200	39	drugs	drug	NOUN
admet-2334	200	40	doi	doi	NOUN
admet-2334	200	41	:	:	PUNCT
admet-2334	200	42	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	200	43	729	729	NUM
admet-2334	200	44	figure	figure	NOUN
admet-2334	200	45	7	7	NUM
admet-2334	200	46	.	.	PUNCT
admet-2334	201	1	chemical	chemical	NOUN
admet-2334	201	2	structures	structure	NOUN
admet-2334	201	3	of	of	ADP
admet-2334	201	4	the	the	DET
admet-2334	201	5	investigated	investigate	VERB
admet-2334	201	6	protacs	protac	NOUN
admet-2334	201	7	:	:	PUNCT
admet-2334	201	8	the	the	DET
admet-2334	201	9	poi	poi	PROPN
admet-2334	201	10	ligand	ligand	NOUN
admet-2334	201	11	is	be	AUX
admet-2334	201	12	in	in	ADP
admet-2334	201	13	blue	blue	ADJ
admet-2334	201	14	circles	circle	NOUN
admet-2334	201	15	,	,	PUNCT
admet-2334	201	16	the	the	DET
admet-2334	201	17	e3	e3	NOUN
admet-2334	201	18	ligase	ligase	NOUN
admet-2334	201	19	ligand	ligand	NOUN
admet-2334	201	20	is	be	AUX
admet-2334	201	21	in	in	ADP
admet-2334	201	22	pink	pink	ADJ
admet-2334	201	23	(	(	PUNCT
admet-2334	201	24	crbn	crbn	NOUN
admet-2334	201	25	)	)	PUNCT
admet-2334	201	26	and	and	CCONJ
admet-2334	201	27	in	in	ADP
admet-2334	201	28	green	green	ADJ
admet-2334	201	29	(	(	PUNCT
admet-2334	201	30	vhl	vhl	PROPN
admet-2334	201	31	)	)	PUNCT
admet-2334	201	32	.	.	PUNCT
admet-2334	202	1	arv-110	arv-110	PROPN
admet-2334	202	2	,	,	PUNCT
admet-2334	202	3	bavdegalutamide	bavdegalutamide	NOUN
admet-2334	202	4	,	,	PUNCT
admet-2334	202	5	is	be	AUX
admet-2334	202	6	the	the	DET
admet-2334	202	7	first	first	ADJ
admet-2334	202	8	protac	protac	NOUN
admet-2334	202	9	that	that	PRON
admet-2334	202	10	entered	enter	VERB
admet-2334	202	11	the	the	DET
admet-2334	202	12	clinics	clinic	NOUN
admet-2334	202	13	,	,	PUNCT
admet-2334	202	14	and	and	CCONJ
admet-2334	202	15	it	it	PRON
admet-2334	202	16	is	be	AUX
admet-2334	202	17	currently	currently	ADV
admet-2334	202	18	in	in	ADP
admet-2334	202	19	phase	phase	NOUN
admet-2334	202	20	ii	ii	NOUN
admet-2334	202	21	clinical	clinical	ADJ
admet-2334	202	22	trials	trial	NOUN
admet-2334	202	23	for	for	ADP
admet-2334	202	24	the	the	DET
admet-2334	202	25	treatment	treatment	NOUN
admet-2334	202	26	of	of	ADP
admet-2334	202	27	metastatic	metastatic	ADJ
admet-2334	202	28	castration	castration	NOUN
admet-2334	202	29	-	-	PUNCT
admet-2334	202	30	resistant	resistant	ADJ
admet-2334	202	31	prostate	prostate	NOUN
admet-2334	202	32	cancer	cancer	NOUN
admet-2334	202	33	(	(	PUNCT
admet-2334	202	34	mcrpc	mcrpc	NOUN
admet-2334	202	35	,	,	PUNCT
admet-2334	202	36	nct03888612	nct03888612	NOUN
admet-2334	202	37	)	)	PUNCT
admet-2334	202	38	.	.	PUNCT
admet-2334	203	1	arv-110	arv-110	PROPN
admet-2334	203	2	is	be	AUX
admet-2334	203	3	an	an	DET
admet-2334	203	4	orally	orally	ADV
admet-2334	203	5	bioavailable	bioavailable	ADJ
admet-2334	203	6	crbn	crbn	NOUN
admet-2334	203	7	degrader	degrader	NOUN
admet-2334	203	8	targeting	target	VERB
admet-2334	203	9	ar	ar	NOUN
admet-2334	203	10	(	(	PUNCT
admet-2334	203	11	androgen	androgen	NOUN
admet-2334	203	12	receptor	receptor	NOUN
admet-2334	203	13	)	)	PUNCT
admet-2334	203	14	and	and	CCONJ
admet-2334	203	15	developed	develop	VERB
admet-2334	203	16	by	by	ADP
admet-2334	203	17	arvinas	arvina	NOUN
admet-2334	203	18	,	,	PUNCT
admet-2334	203	19	inc	inc	PROPN
admet-2334	203	20	.	.	PUNCT
admet-2334	204	1	its	its	PRON
admet-2334	204	2	efficacy	efficacy	NOUN
admet-2334	204	3	was	be	AUX
admet-2334	204	4	demonstrated	demonstrate	VERB
admet-2334	204	5	both	both	CCONJ
admet-2334	204	6	in	in	ADP
admet-2334	204	7	vitro	vitro	X
admet-2334	204	8	(	(	PUNCT
admet-2334	204	9	dc50	dc50	PROPN
admet-2334	204	10	around	around	ADP
admet-2334	204	11	1	1	NUM
admet-2334	204	12	nm	nm	NOUN
admet-2334	204	13	in	in	ADP
admet-2334	204	14	all	all	DET
admet-2334	204	15	tested	test	VERB
admet-2334	204	16	prostatic	prostatic	ADJ
admet-2334	204	17	cancer	cancer	NOUN
admet-2334	204	18	cell	cell	NOUN
admet-2334	204	19	lines	line	NOUN
admet-2334	204	20	)	)	PUNCT
admet-2334	204	21	and	and	CCONJ
admet-2334	204	22	in	in	ADP
admet-2334	204	23	vivo	vivo	NOUN
admet-2334	204	24	,	,	PUNCT
admet-2334	204	25	where	where	SCONJ
admet-2334	204	26	it	it	PRON
admet-2334	204	27	significantly	significantly	ADV
admet-2334	204	28	inhibited	inhibit	VERB
admet-2334	204	29	the	the	DET
admet-2334	204	30	growth	growth	NOUN
admet-2334	204	31	of	of	ADP
admet-2334	204	32	enzalutamide	enzalutamide	ADV
admet-2334	204	33	-	-	PUNCT
admet-2334	204	34	insensitive	insensitive	ADJ
admet-2334	204	35	tumours	tumour	NOUN
admet-2334	205	1	[	[	X
admet-2334	205	2	43	43	NUM
admet-2334	205	3	]	]	PUNCT
admet-2334	205	4	.	.	PUNCT
admet-2334	206	1	in	in	ADP
admet-2334	206	2	2019	2019	NUM
admet-2334	206	3	arv-110	arv-110	ADJ
admet-2334	206	4	entered	enter	VERB
admet-2334	206	5	phase	phase	NOUN
admet-2334	206	6	i	i	PRON
admet-2334	206	7	,	,	PUNCT
admet-2334	206	8	where	where	SCONJ
admet-2334	206	9	its	its	PRON
admet-2334	206	10	safety	safety	NOUN
admet-2334	206	11	,	,	PUNCT
admet-2334	206	12	tolerability	tolerability	NOUN
admet-2334	206	13	and	and	CCONJ
admet-2334	206	14	pharmacokinetics	pharmacokinetic	NOUN
admet-2334	206	15	were	be	AUX
admet-2334	206	16	evaluated	evaluate	VERB
admet-2334	206	17	in	in	ADP
admet-2334	206	18	mcrpc	mcrpc	NOUN
admet-2334	206	19	-	-	PUNCT
admet-2334	206	20	positive	positive	ADJ
admet-2334	206	21	patients	patient	NOUN
admet-2334	206	22	not	not	PART
admet-2334	206	23	responding	respond	VERB
admet-2334	206	24	to	to	ADP
admet-2334	206	25	traditional	traditional	ADJ
admet-2334	206	26	pharmacological	pharmacological	ADJ
admet-2334	206	27	treatment	treatment	NOUN
admet-2334	206	28	.	.	PUNCT
admet-2334	207	1	due	due	ADP
admet-2334	207	2	to	to	ADP
admet-2334	207	3	the	the	DET
admet-2334	207	4	promising	promising	ADJ
admet-2334	207	5	results	result	NOUN
admet-2334	207	6	reported	report	VERB
admet-2334	207	7	in	in	ADP
admet-2334	207	8	pretreated	pretreate	VERB
admet-2334	207	9	mcrpc	mcrpc	NOUN
admet-2334	207	10	patients	patient	NOUN
admet-2334	207	11	,	,	PUNCT
admet-2334	207	12	it	it	PRON
admet-2334	207	13	entered	enter	VERB
admet-2334	207	14	phase	phase	NOUN
admet-2334	207	15	ii	ii	NOUN
admet-2334	207	16	for	for	ADP
admet-2334	207	17	further	further	ADJ
admet-2334	207	18	evaluation	evaluation	NOUN
admet-2334	207	19	.	.	PUNCT
admet-2334	208	1	arv-471	arv-471	NOUN
admet-2334	208	2	,	,	PUNCT
admet-2334	208	3	also	also	ADV
admet-2334	208	4	known	know	VERB
admet-2334	208	5	as	as	ADP
admet-2334	208	6	vepdegestrant	vepdegestrant	NOUN
admet-2334	208	7	,	,	PUNCT
admet-2334	208	8	is	be	AUX
admet-2334	208	9	an	an	DET
admet-2334	208	10	orally	orally	ADV
admet-2334	208	11	bioavailable	bioavailable	ADJ
admet-2334	208	12	crbn	crbn	NOUN
admet-2334	208	13	-	-	PUNCT
admet-2334	208	14	recruiting	recruit	VERB
admet-2334	208	15	er	er	INTJ
admet-2334	208	16	(	(	PUNCT
admet-2334	208	17	estrogen	estrogen	NOUN
admet-2334	208	18	receptor	receptor	NOUN
admet-2334	208	19	)	)	PUNCT
admet-2334	208	20	targeting	target	VERB
admet-2334	208	21	degrader	degrader	NOUN
admet-2334	208	22	currently	currently	ADV
admet-2334	208	23	in	in	ADP
admet-2334	208	24	phase	phase	NOUN
admet-2334	208	25	iii	iii	NUM
admet-2334	208	26	clinical	clinical	ADJ
admet-2334	208	27	trials	trial	NOUN
admet-2334	208	28	for	for	ADP
admet-2334	208	29	the	the	DET
admet-2334	208	30	treatment	treatment	NOUN
admet-2334	208	31	of	of	ADP
admet-2334	208	32	er	er	INTJ
admet-2334	208	33	-	-	PUNCT
admet-2334	208	34	positive	positive	ADJ
admet-2334	208	35	/	/	SYM
admet-2334	208	36	her2	her2	PROPN
admet-2334	208	37	(	(	PUNCT
admet-2334	208	38	human	human	ADJ
admet-2334	208	39	epidermal	epidermal	ADJ
admet-2334	208	40	growth	growth	NOUN
admet-2334	208	41	factor	factor	NOUN
admet-2334	208	42	2	2	NUM
admet-2334	208	43	)	)	PUNCT
admet-2334	208	44	negative	negative	ADJ
admet-2334	208	45	locally	locally	ADV
admet-2334	208	46	advanced	advanced	ADJ
admet-2334	208	47	or	or	CCONJ
admet-2334	208	48	metastatic	metastatic	ADJ
admet-2334	208	49	breast	breast	NOUN
admet-2334	208	50	(	(	PUNCT
admet-2334	208	51	veritac-2	veritac-2	NUM
admet-2334	208	52	,	,	PUNCT
admet-2334	208	53	nct05654623	nct05654623	NOUN
admet-2334	208	54	)	)	PUNCT
admet-2334	208	55	.	.	PUNCT
admet-2334	209	1	arvinas	arvina	NOUN
admet-2334	209	2	and	and	CCONJ
admet-2334	209	3	pfizer	pfizer	NOUN
admet-2334	209	4	are	be	AUX
admet-2334	209	5	collaborating	collaborate	VERB
admet-2334	209	6	for	for	ADP
admet-2334	209	7	the	the	DET
admet-2334	209	8	co	co	NOUN
admet-2334	209	9	-	-	NOUN
admet-2334	209	10	development	development	NOUN
admet-2334	209	11	and	and	CCONJ
admet-2334	209	12	co	co	NOUN
admet-2334	209	13	-	-	NOUN
admet-2334	209	14	commercialization	commercialization	NOUN
admet-2334	209	15	of	of	ADP
admet-2334	209	16	arv-471	arv-471	NOUN
admet-2334	209	17	,	,	PUNCT
admet-2334	209	18	which	which	PRON
admet-2334	209	19	showed	show	VERB
admet-2334	209	20	promising	promising	ADJ
admet-2334	209	21	results	result	NOUN
admet-2334	209	22	both	both	CCONJ
admet-2334	209	23	in	in	ADP
admet-2334	209	24	vitro	vitro	X
admet-2334	209	25	(	(	PUNCT
admet-2334	209	26	er	er	INTJ
admet-2334	209	27	degradation	degradation	NOUN
admet-2334	209	28	up	up	ADP
admet-2334	209	29	to	to	PART
admet-2334	209	30	97	97	NUM
admet-2334	209	31	%	%	NOUN
admet-2334	209	32	in	in	ADP
admet-2334	209	33	tumor	tumor	NOUN
admet-2334	209	34	cell	cell	NOUN
admet-2334	209	35	lines	line	NOUN
admet-2334	209	36	)	)	PUNCT
admet-2334	209	37	and	and	CCONJ
admet-2334	209	38	in	in	ADP
admet-2334	209	39	vivo	vivo	NOUN
admet-2334	209	40	models	model	NOUN
admet-2334	209	41	.	.	PUNCT
admet-2334	210	1	er	er	INTJ
admet-2334	210	2	degrader	degrader	NOUN
admet-2334	210	3	was	be	AUX
admet-2334	210	4	well	well	ADV
admet-2334	210	5	tolerated	tolerate	VERB
admet-2334	210	6	across	across	ADP
admet-2334	210	7	all	all	DET
admet-2334	210	8	doses	dose	NOUN
admet-2334	210	9	orally	orally	ADV
admet-2334	210	10	administered	administer	VERB
admet-2334	210	11	and	and	CCONJ
admet-2334	210	12	showed	show	VERB
admet-2334	210	13	clinical	clinical	ADJ
admet-2334	210	14	activity	activity	NOUN
admet-2334	210	15	in	in	ADP
admet-2334	210	16	advanced	advanced	ADJ
admet-2334	210	17	breast	breast	NOUN
admet-2334	210	18	cancer	cancer	NOUN
admet-2334	210	19	patients	patient	NOUN
admet-2334	210	20	during	during	ADP
admet-2334	210	21	phase	phase	NOUN
admet-2334	210	22	i	i	PRON
admet-2334	210	23	and	and	CCONJ
admet-2334	210	24	ii	ii	VERB
admet-2334	211	1	[	[	X
admet-2334	211	2	44	44	NUM
admet-2334	211	3	]	]	PUNCT
admet-2334	211	4	.	.	PUNCT
admet-2334	212	1	dt-2216	dt-2216	PROPN
admet-2334	212	2	is	be	AUX
admet-2334	212	3	a	a	DET
admet-2334	212	4	vhl	vhl	PROPN
admet-2334	212	5	intravenous	intravenous	ADJ
admet-2334	212	6	protac	protac	NOUN
admet-2334	212	7	targeting	target	VERB
admet-2334	212	8	bcl	bcl	PROPN
admet-2334	212	9	-	-	PROPN
admet-2334	212	10	xl	xl	PROPN
admet-2334	212	11	(	(	PUNCT
admet-2334	212	12	b	b	X
admet-2334	212	13	-	-	PUNCT
admet-2334	212	14	cell	cell	NOUN
admet-2334	212	15	lymphoma	lymphoma	NOUN
admet-2334	213	1	extra	extra	ADJ
admet-2334	213	2	-	-	ADJ
admet-2334	213	3	large	large	ADJ
admet-2334	213	4	)	)	PUNCT
admet-2334	213	5	for	for	ADP
admet-2334	213	6	the	the	DET
admet-2334	213	7	treatment	treatment	NOUN
admet-2334	213	8	of	of	ADP
admet-2334	213	9	solid	solid	ADJ
admet-2334	213	10	tumors	tumor	NOUN
admet-2334	213	11	and	and	CCONJ
admet-2334	213	12	hematologic	hematologic	NOUN
admet-2334	213	13	malignancies	malignancy	NOUN
admet-2334	213	14	commercialized	commercialize	VERB
admet-2334	213	15	by	by	ADP
admet-2334	213	16	dialectic	dialectic	NOUN
admet-2334	213	17	.	.	PUNCT
admet-2334	214	1	in	in	ADP
admet-2334	214	2	preclinical	preclinical	ADJ
admet-2334	214	3	studies	study	NOUN
admet-2334	214	4	,	,	PUNCT
admet-2334	214	5	dt-2216	dt-2216	VERB
admet-2334	214	6	selectively	selectively	ADV
admet-2334	214	7	induced	induce	VERB
admet-2334	214	8	degradation	degradation	NOUN
admet-2334	214	9	of	of	ADP
admet-2334	214	10	bcl	bcl	PROPN
admet-2334	214	11	-	-	PROPN
admet-2334	214	12	xl	xl	PROPN
admet-2334	214	13	in	in	ADP
admet-2334	214	14	cancer	cancer	NOUN
admet-2334	214	15	cells	cell	NOUN
admet-2334	214	16	[	[	X
admet-2334	214	17	45	45	NUM
admet-2334	214	18	]	]	PUNCT
admet-2334	214	19	.	.	PUNCT
admet-2334	215	1	it	it	PRON
admet-2334	215	2	is	be	AUX
admet-2334	215	3	currently	currently	ADV
admet-2334	215	4	in	in	ADP
admet-2334	215	5	phase	phase	NOUN
admet-2334	215	6	i	i	PRON
admet-2334	215	7	clinical	clinical	ADJ
admet-2334	215	8	trials	trial	NOUN
admet-2334	215	9	to	to	PART
admet-2334	215	10	evaluate	evaluate	VERB
admet-2334	215	11	adverse	adverse	ADJ
admet-2334	215	12	events	event	NOUN
admet-2334	215	13	,	,	PUNCT
admet-2334	215	14	dose	dose	NOUN
admet-2334	215	15	-	-	PUNCT
admet-2334	215	16	limiting	limit	VERB
admet-2334	215	17	toxicity	toxicity	NOUN
admet-2334	215	18	,	,	PUNCT
admet-2334	215	19	and	and	CCONJ
admet-2334	215	20	the	the	DET
admet-2334	215	21	pharmacokinetic	pharmacokinetic	ADJ
admet-2334	215	22	profile	profile	NOUN
admet-2334	215	23	(	(	PUNCT
admet-2334	215	24	nct04886622	nct04886622	NOUN
admet-2334	215	25	)	)	PUNCT
admet-2334	215	26	.	.	PUNCT
admet-2334	216	1	in	in	ADP
admet-2334	216	2	contrast	contrast	NOUN
admet-2334	216	3	with	with	ADP
admet-2334	216	4	arv110	arv110	PROPN
admet-2334	216	5	and	and	CCONJ
admet-2334	216	6	arv-471	arv-471	NOUN
admet-2334	216	7	,	,	PUNCT
admet-2334	216	8	characterized	characterize	VERB
admet-2334	216	9	by	by	ADP
admet-2334	216	10	a	a	DET
admet-2334	216	11	quite	quite	ADV
admet-2334	216	12	high	high	ADJ
admet-2334	216	13	oral	oral	ADJ
admet-2334	216	14	bioavailability	bioavailability	NOUN
admet-2334	216	15	(	(	PUNCT
admet-2334	216	16	f	f	X
admet-2334	216	17	>	>	X
admet-2334	216	18	30	30	NUM
admet-2334	216	19	%	%	NOUN
admet-2334	216	20	,	,	PUNCT
admet-2334	216	21	preclinical	preclinical	ADJ
admet-2334	216	22	models	model	NOUN
admet-2334	216	23	)	)	PUNCT
admet-2334	216	24	,	,	PUNCT
admet-2334	216	25	dt-2216	dt-2216	PROPN
admet-2334	216	26	is	be	AUX
admet-2334	216	27	characterized	characterize	VERB
admet-2334	216	28	by	by	ADP
admet-2334	216	29	a	a	DET
admet-2334	216	30	very	very	ADV
admet-2334	216	31	low	low	ADJ
admet-2334	216	32	oral	oral	ADJ
admet-2334	216	33	bioavailability	bioavailability	NOUN
admet-2334	216	34	(	(	PUNCT
admet-2334	216	35	f	f	X
admet-2334	216	36	<	<	X
admet-2334	216	37	0.03	0.03	NUM
admet-2334	216	38	%	%	NOUN
admet-2334	216	39	,	,	PUNCT
admet-2334	216	40	mouse	mouse	NOUN
admet-2334	216	41	)	)	PUNCT
admet-2334	216	42	.	.	PUNCT
admet-2334	217	1	while	while	SCONJ
admet-2334	217	2	both	both	PRON
admet-2334	217	3	arv-110	arv-110	ADJ
admet-2334	217	4	and	and	CCONJ
admet-2334	217	5	arv-471	arv-471	NOUN
admet-2334	217	6	are	be	AUX
admet-2334	217	7	crbn	crbn	NOUN
admet-2334	217	8	-	-	PUNCT
admet-2334	217	9	based	base	VERB
admet-2334	217	10	protacs	protac	NOUN
admet-2334	217	11	,	,	PUNCT
admet-2334	217	12	dt-2216	dt-2216	PROPN
admet-2334	217	13	is	be	AUX
admet-2334	217	14	a	a	DET
admet-2334	217	15	vhl	vhl	NOUN
admet-2334	217	16	-	-	PUNCT
admet-2334	217	17	based	base	VERB
admet-2334	217	18	degrader	degrader	NOUN
admet-2334	217	19	(	(	PUNCT
admet-2334	217	20	figure	figure	NOUN
admet-2334	217	21	7	7	NUM
admet-2334	217	22	)	)	PUNCT
admet-2334	217	23	.	.	PUNCT
admet-2334	218	1	first	first	ADV
admet-2334	218	2	we	we	PRON
admet-2334	218	3	calculated	calculate	VERB
admet-2334	218	4	2d	2d	NUM
admet-2334	218	5	descriptors	descriptor	NOUN
admet-2334	218	6	for	for	ADP
admet-2334	218	7	the	the	DET
admet-2334	218	8	considered	consider	VERB
admet-2334	218	9	protacs	protac	NOUN
admet-2334	218	10	(	(	PUNCT
admet-2334	218	11	table	table	NOUN
admet-2334	218	12	1	1	NUM
admet-2334	218	13	)	)	PUNCT
admet-2334	218	14	.	.	PUNCT
admet-2334	219	1	dt-2216	dt-2216	PROPN
admet-2334	219	2	is	be	AUX
admet-2334	219	3	characterized	characterize	VERB
admet-2334	219	4	by	by	ADP
admet-2334	219	5	a	a	DET
admet-2334	219	6	quite	quite	ADV
admet-2334	219	7	different	different	ADJ
admet-2334	219	8	physicochemical	physicochemical	ADJ
admet-2334	219	9	properties	property	NOUN
admet-2334	219	10	profile	profile	VERB
admet-2334	219	11	compared	compare	VERB
admet-2334	219	12	to	to	ADP
admet-2334	219	13	arv-110	arv-110	NOUN
admet-2334	219	14	and	and	CCONJ
admet-2334	219	15	arv-471	arv-471	NOUN
admet-2334	219	16	,	,	PUNCT
admet-2334	219	17	and	and	CCONJ
admet-2334	219	18	as	as	SCONJ
admet-2334	219	19	expected	expect	VERB
admet-2334	219	20	,	,	PUNCT
admet-2334	219	21	it	it	PRON
admet-2334	219	22	can	can	AUX
admet-2334	219	23	be	be	AUX
admet-2334	219	24	localized	localize	VERB
admet-2334	219	25	far	far	ADV
admet-2334	219	26	from	from	ADP
admet-2334	219	27	the	the	DET
admet-2334	219	28	fda	fda	PROPN
admet-2334	219	29	-	-	PUNCT
admet-2334	219	30	approved	approve	VERB
admet-2334	219	31	small	small	ADJ
admet-2334	219	32	molecule	molecule	NOUN
admet-2334	219	33	and	and	CCONJ
admet-2334	219	34	crbn	crbn	NOUN
admet-2334	219	35	oral	oral	ADJ
admet-2334	219	36	protacs	protac	NOUN
admet-2334	219	37	in	in	ADP
admet-2334	219	38	the	the	DET
admet-2334	219	39	chemical	chemical	NOUN
admet-2334	219	40	2d	2d	NUM
admet-2334	219	41	space	space	NOUN
admet-2334	220	1	[	[	X
admet-2334	220	2	46	46	NUM
admet-2334	220	3	]	]	PUNCT
admet-2334	220	4	.	.	PUNCT
admet-2334	221	1	dt-2216	dt-2216	PROPN
admet-2334	221	2	is	be	AUX
admet-2334	221	3	indeed	indeed	ADV
admet-2334	221	4	larger	large	ADJ
admet-2334	221	5	,	,	PUNCT
admet-2334	221	6	more	more	ADV
admet-2334	221	7	hydrophobic	hydrophobic	ADJ
admet-2334	221	8	,	,	PUNCT
admet-2334	221	9	more	more	ADV
admet-2334	221	10	polar	polar	ADJ
admet-2334	221	11	,	,	PUNCT
admet-2334	221	12	and	and	CCONJ
admet-2334	221	13	more	more	ADV
admet-2334	221	14	flexible	flexible	ADJ
admet-2334	221	15	than	than	ADP
admet-2334	221	16	arv-110	arv-110	ADJ
admet-2334	221	17	and	and	CCONJ
admet-2334	221	18	arv-471	arv-471	NOUN
admet-2334	221	19	.	.	PUNCT
admet-2334	222	1	dt-2216	dt-2216	PROPN
admet-2334	222	2	arv-471arv-110	arv-471arv-110	PROPN
admet-2334	222	3	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	NOUN
admet-2334	223	1	d.	d.	PROPN
admet-2334	223	2	g.	g.	PROPN
admet-2334	223	3	jiménez	jiménez	PROPN
admet-2334	223	4	et	et	PROPN
admet-2334	223	5	al	al	PROPN
admet-2334	223	6	.	.	PROPN
admet-2334	223	7	admet	admet	PROPN
admet-2334	223	8	&	&	CCONJ
admet-2334	223	9	dmpk	dmpk	PROPN
admet-2334	223	10	12(5	12(5	NUM
admet-2334	223	11	)	)	PUNCT
admet-2334	223	12	(	(	PUNCT
admet-2334	223	13	2024	2024	NUM
admet-2334	223	14	)	)	PUNCT
admet-2334	223	15	721	721	NUM
admet-2334	223	16	-	-	NUM
admet-2334	223	17	736	736	NUM
admet-2334	223	18	730	730	NUM
admet-2334	223	19	table	table	NOUN
admet-2334	223	20	1	1	NUM
admet-2334	223	21	.	.	X
admet-2334	223	22	2d	2d	NOUN
admet-2334	223	23	physicochemical	physicochemical	ADJ
admet-2334	223	24	descriptors	descriptor	NOUN
admet-2334	223	25	calculated	calculate	VERB
admet-2334	223	26	using	use	VERB
admet-2334	223	27	alvadesc	alvadesc	NOUN
admet-2334	223	28	and	and	CCONJ
admet-2334	223	29	datawarrior	datawarrior	ADJ
admet-2334	223	30	(	(	PUNCT
admet-2334	223	31	see	see	VERB
admet-2334	223	32	methods	method	NOUN
admet-2334	223	33	)	)	PUNCT
admet-2334	223	34	.	.	PUNCT
admet-2334	224	1	size	size	NOUN
admet-2334	224	2	descriptors	descriptor	NOUN
admet-2334	224	3	:	:	PUNCT
admet-2334	224	4	mw	mw	ADJ
admet-2334	224	5	:	:	PUNCT
admet-2334	224	6	molecular	molecular	ADJ
admet-2334	224	7	weight	weight	NOUN
admet-2334	224	8	;	;	PUNCT
admet-2334	224	9	nc	nc	PROPN
admet-2334	224	10	:	:	PUNCT
admet-2334	224	11	the	the	DET
admet-2334	224	12	number	number	NOUN
admet-2334	224	13	of	of	ADP
admet-2334	224	14	carbon	carbon	NOUN
admet-2334	224	15	atoms	atom	NOUN
admet-2334	224	16	in	in	ADP
admet-2334	224	17	the	the	DET
admet-2334	224	18	molecule	molecule	NOUN
admet-2334	224	19	.	.	PUNCT
admet-2334	225	1	flexibility	flexibility	NOUN
admet-2334	225	2	descriptors	descriptor	NOUN
admet-2334	225	3	:	:	PUNCT
admet-2334	225	4	phi	phi	NOUN
admet-2334	225	5	:	:	PUNCT
admet-2334	225	6	kier	kier	PROPN
admet-2334	225	7	’s	’s	PART
admet-2334	225	8	flexibility	flexibility	NOUN
admet-2334	225	9	index	index	NOUN
admet-2334	225	10	and	and	CCONJ
admet-2334	225	11	nrot	nrot	NOUN
admet-2334	225	12	:	:	PUNCT
admet-2334	225	13	the	the	DET
admet-2334	225	14	number	number	NOUN
admet-2334	225	15	of	of	ADP
admet-2334	225	16	rotatable	rotatable	ADJ
admet-2334	225	17	bonds	bond	NOUN
admet-2334	225	18	.	.	PUNCT
admet-2334	226	1	polarity	polarity	NOUN
admet-2334	226	2	descriptors	descriptor	NOUN
admet-2334	226	3	:	:	PUNCT
admet-2334	226	4	hbd	hbd	NOUN
admet-2334	226	5	:	:	PUNCT
admet-2334	226	6	number	number	NOUN
admet-2334	226	7	of	of	ADP
admet-2334	226	8	hydrogen	hydrogen	NOUN
admet-2334	226	9	bond	bond	NOUN
admet-2334	226	10	donors	donor	NOUN
admet-2334	226	11	,	,	PUNCT
admet-2334	226	12	hba	hba	NOUN
admet-2334	226	13	:	:	PUNCT
admet-2334	226	14	number	number	NOUN
admet-2334	226	15	of	of	ADP
admet-2334	226	16	hydrogen	hydrogen	NOUN
admet-2334	226	17	bond	bond	NOUN
admet-2334	226	18	acceptors	acceptor	NOUN
admet-2334	226	19	and	and	CCONJ
admet-2334	226	20	tpsa	tpsa	PROPN
admet-2334	226	21	:	:	PUNCT
admet-2334	226	22	topological	topological	ADJ
admet-2334	226	23	polar	polar	ADJ
admet-2334	226	24	surface	surface	NOUN
admet-2334	226	25	area	area	NOUN
admet-2334	226	26	.	.	PUNCT
admet-2334	227	1	compound	compound	PROPN
admet-2334	227	2	mw	mw	PROPN
admet-2334	227	3	nc	nc	PROPN
admet-2334	227	4	phi	phi	PROPN
admet-2334	227	5	nrot	nrot	PROPN
admet-2334	227	6	hbd	hbd	PROPN
admet-2334	227	7	hba	hba	PROPN
admet-2334	227	8	tpsa	tpsa	PROPN
admet-2334	227	9	arv-110	arv-110	VERB
admet-2334	227	10	812.38	812.38	NUM
admet-2334	227	11	41	41	NUM
admet-2334	227	12	11.96	11.96	NUM
admet-2334	227	13	9	9	NUM
admet-2334	227	14	2	2	NUM
admet-2334	227	15	16	16	NUM
admet-2334	227	16	182.86	182.86	NUM
admet-2334	227	17	arv-471	arv-471	NOUN
admet-2334	227	18	723.99	723.99	NUM
admet-2334	227	19	45	45	NUM
admet-2334	227	20	9.87	9.87	NUM
admet-2334	227	21	7	7	NUM
admet-2334	227	22	2	2	NUM
admet-2334	227	23	9	9	NUM
admet-2334	227	24	96.43	96.43	NUM
admet-2334	227	25	dt2216	dt2216	NOUN
admet-2334	227	26	1542.56	1542.56	NUM
admet-2334	227	27	77	77	NUM
admet-2334	227	28	27.58	27.58	NUM
admet-2334	227	29	29	29	NUM
admet-2334	227	30	5	5	NUM
admet-2334	227	31	23	23	NUM
admet-2334	227	32	321.37	321.37	NUM
admet-2334	227	33	a	a	DET
admet-2334	227	34	recent	recent	ADJ
admet-2334	227	35	paper	paper	NOUN
admet-2334	227	36	by	by	ADP
admet-2334	227	37	arvinas	arvina	NOUN
admet-2334	227	38	researchers	researcher	NOUN
admet-2334	227	39	[	[	X
admet-2334	227	40	47	47	NUM
admet-2334	227	41	]	]	PUNCT
admet-2334	227	42	reported	report	VERB
admet-2334	227	43	constraints	constraint	NOUN
admet-2334	227	44	on	on	ADP
admet-2334	227	45	protac	protac	ADJ
admet-2334	227	46	2d	2d	NUM
admet-2334	227	47	physicochemical	physicochemical	ADJ
admet-2334	227	48	calculated	calculate	VERB
admet-2334	227	49	descriptors	descriptor	NOUN
admet-2334	227	50	associated	associate	VERB
admet-2334	227	51	with	with	ADP
admet-2334	227	52	a	a	DET
admet-2334	227	53	higher	high	ADJ
admet-2334	227	54	probability	probability	NOUN
admet-2334	227	55	of	of	ADP
admet-2334	227	56	being	be	AUX
admet-2334	227	57	orally	orally	ADV
admet-2334	227	58	absorbed	absorb	VERB
admet-2334	227	59	.	.	PUNCT
admet-2334	228	1	specifically	specifically	ADV
admet-2334	228	2	,	,	PUNCT
admet-2334	228	3	a	a	DET
admet-2334	228	4	distinct	distinct	ADJ
admet-2334	228	5	cut	cut	NOUN
admet-2334	228	6	-	-	PUNCT
admet-2334	228	7	off	off	NOUN
admet-2334	228	8	was	be	AUX
admet-2334	228	9	observed	observe	VERB
admet-2334	228	10	for	for	ADP
admet-2334	228	11	hbd	hbd	NOUN
admet-2334	228	12	,	,	PUNCT
admet-2334	228	13	which	which	DET
admet-2334	228	14	dt2216	dt2216	PROPN
admet-2334	228	15	does	do	AUX
admet-2334	228	16	not	not	PART
admet-2334	228	17	meet	meet	VERB
admet-2334	228	18	.	.	PUNCT
admet-2334	229	1	additionally	additionally	ADV
admet-2334	229	2	,	,	PUNCT
admet-2334	229	3	the	the	DET
admet-2334	229	4	same	same	ADJ
admet-2334	229	5	protac	protac	NOUN
admet-2334	229	6	also	also	ADV
admet-2334	229	7	exceeds	exceed	VERB
admet-2334	229	8	the	the	DET
admet-2334	229	9	hba	hba	NOUN
admet-2334	229	10	threshold	threshold	NOUN
admet-2334	229	11	of	of	ADP
admet-2334	229	12	15	15	NUM
admet-2334	229	13	.	.	PUNCT
admet-2334	230	1	then	then	ADV
admet-2334	230	2	,	,	PUNCT
admet-2334	230	3	we	we	PRON
admet-2334	230	4	focused	focus	VERB
admet-2334	230	5	on	on	ADP
admet-2334	230	6	experimental	experimental	ADJ
admet-2334	230	7	descriptors	descriptor	NOUN
admet-2334	230	8	.	.	PUNCT
admet-2334	231	1	we	we	PRON
admet-2334	231	2	first	first	ADV
admet-2334	231	3	explored	explore	VERB
admet-2334	231	4	the	the	DET
admet-2334	231	5	ionization	ionization	NOUN
admet-2334	231	6	behavior	behavior	NOUN
admet-2334	231	7	of	of	ADP
admet-2334	231	8	the	the	DET
admet-2334	231	9	three	three	NUM
admet-2334	231	10	protacs	protac	NOUN
admet-2334	231	11	by	by	ADP
admet-2334	231	12	monitoring	monitor	VERB
admet-2334	231	13	the	the	DET
admet-2334	231	14	variation	variation	NOUN
admet-2334	231	15	in	in	ADP
admet-2334	231	16	log	log	PROPN
admet-2334	231	17	k'80	k'80	NOUN
admet-2334	231	18	plrp	plrp	NOUN
admet-2334	231	19	-	-	PUNCT
admet-2334	231	20	s	s	NOUN
admet-2334	231	21	at	at	ADP
admet-2334	231	22	three	three	NUM
admet-2334	231	23	phs	ph	NOUN
admet-2334	231	24	.	.	PUNCT
admet-2334	231	25	figure	figure	NOUN
admet-2334	231	26	8	8	NUM
admet-2334	231	27	shows	show	VERB
admet-2334	231	28	that	that	SCONJ
admet-2334	231	29	arv-110	arv-110	PROPN
admet-2334	231	30	(	(	PUNCT
admet-2334	231	31	blue	blue	ADJ
admet-2334	231	32	)	)	PUNCT
admet-2334	231	33	and	and	CCONJ
admet-2334	231	34	arv-471	arv-471	NOUN
admet-2334	231	35	(	(	PUNCT
admet-2334	231	36	light	light	ADJ
admet-2334	231	37	blue	blue	NOUN
admet-2334	231	38	)	)	PUNCT
admet-2334	231	39	are	be	AUX
admet-2334	231	40	basic	basic	ADJ
admet-2334	231	41	compounds	compound	NOUN
admet-2334	231	42	since	since	SCONJ
admet-2334	231	43	the	the	DET
admet-2334	231	44	logarithm	logarithm	NOUN
admet-2334	231	45	of	of	ADP
admet-2334	231	46	the	the	DET
admet-2334	231	47	capacity	capacity	NOUN
admet-2334	231	48	factor	factor	NOUN
admet-2334	231	49	and	and	CCONJ
admet-2334	231	50	,	,	PUNCT
admet-2334	231	51	thus	thus	ADV
admet-2334	231	52	,	,	PUNCT
admet-2334	231	53	retention	retention	NOUN
admet-2334	231	54	increases	increase	NOUN
admet-2334	231	55	when	when	SCONJ
admet-2334	231	56	passing	pass	VERB
admet-2334	231	57	from	from	ADP
admet-2334	231	58	acidic	acidic	ADJ
admet-2334	231	59	to	to	ADP
admet-2334	231	60	neutral	neutral	ADJ
admet-2334	231	61	and	and	CCONJ
admet-2334	231	62	basic	basic	ADJ
admet-2334	231	63	phs	phs	NOUN
admet-2334	231	64	.	.	PUNCT
admet-2334	232	1	moreover	moreover	ADV
admet-2334	232	2	,	,	PUNCT
admet-2334	232	3	these	these	DET
admet-2334	232	4	two	two	NUM
admet-2334	232	5	protacs	protac	NOUN
admet-2334	232	6	can	can	AUX
admet-2334	232	7	be	be	AUX
admet-2334	232	8	considered	consider	VERB
admet-2334	232	9	predominantly	predominantly	ADV
admet-2334	232	10	neutral	neutral	ADJ
admet-2334	232	11	at	at	ADP
admet-2334	232	12	ph	ph	PROPN
admet-2334	232	13	7	7	NUM
admet-2334	232	14	.	.	PUNCT
admet-2334	232	15	conversely	conversely	ADV
admet-2334	232	16	,	,	PUNCT
admet-2334	232	17	dt2216	dt2216	PROPN
admet-2334	232	18	is	be	AUX
admet-2334	232	19	an	an	DET
admet-2334	232	20	ampholyte	ampholyte	NOUN
admet-2334	232	21	since	since	SCONJ
admet-2334	232	22	it	it	PRON
admet-2334	232	23	shows	show	VERB
admet-2334	232	24	low	low	ADJ
admet-2334	232	25	retention	retention	NOUN
admet-2334	232	26	at	at	ADP
admet-2334	232	27	extreme	extreme	ADJ
admet-2334	232	28	phs	phs	NOUN
admet-2334	232	29	and	and	CCONJ
admet-2334	232	30	the	the	DET
admet-2334	232	31	highest	high	ADJ
admet-2334	232	32	retention	retention	NOUN
admet-2334	232	33	at	at	ADP
admet-2334	232	34	ph	ph	PROPN
admet-2334	232	35	7.0	7.0	NUM
admet-2334	232	36	.	.	PUNCT
admet-2334	233	1	the	the	DET
admet-2334	233	2	complex	complex	ADJ
admet-2334	233	3	ionization	ionization	NOUN
admet-2334	233	4	profile	profile	NOUN
admet-2334	233	5	of	of	ADP
admet-2334	233	6	dt2216	dt2216	PROPN
admet-2334	233	7	prevented	prevent	VERB
admet-2334	233	8	the	the	DET
admet-2334	233	9	measurements	measurement	NOUN
admet-2334	233	10	of	of	ADP
admet-2334	233	11	chamelogk	chamelogk	ADJ
admet-2334	233	12	and	and	CCONJ
admet-2334	233	13			NOUN
admet-2334	233	14	log	log	VERB
admet-2334	233	15	kw	kw	PROPN
admet-2334	233	16	iam	iam	PROPN
admet-2334	233	17	since	since	SCONJ
admet-2334	233	18	these	these	DET
admet-2334	233	19	methods	method	NOUN
admet-2334	233	20	are	be	AUX
admet-2334	233	21	not	not	PART
admet-2334	233	22	validated	validate	VERB
admet-2334	233	23	for	for	ADP
admet-2334	233	24	ampholytes	ampholyte	NOUN
admet-2334	233	25	.	.	PUNCT
admet-2334	234	1	figure	figure	VERB
admet-2334	234	2	8	8	NUM
admet-2334	234	3	.	.	PUNCT
admet-2334	235	1	ionization	ionization	NOUN
admet-2334	235	2	behavior	behavior	NOUN
admet-2334	235	3	of	of	ADP
admet-2334	235	4	the	the	DET
admet-2334	235	5	investigated	investigate	VERB
admet-2334	235	6	compounds	compound	NOUN
admet-2334	235	7	:	:	PUNCT
admet-2334	235	8	dt2216	dt2216	PROPN
admet-2334	235	9	,	,	PUNCT
admet-2334	235	10	arv-110	arv-110	NOUN
admet-2334	235	11	and	and	CCONJ
admet-2334	235	12	arv-471	arv-471	NOUN
admet-2334	235	13	(	(	PUNCT
admet-2334	235	14	arv-825	arv-825	PROPN
admet-2334	235	15	and	and	CCONJ
admet-2334	235	16	asunaprevir	asunaprevir	PROPN
admet-2334	235	17	are	be	AUX
admet-2334	235	18	reported	report	VERB
admet-2334	235	19	as	as	ADP
admet-2334	235	20	examples	example	NOUN
admet-2334	235	21	of	of	ADP
admet-2334	235	22	nonionizable	nonionizable	ADJ
admet-2334	235	23	and	and	CCONJ
admet-2334	235	24	acidic	acidic	ADJ
admet-2334	235	25	bro5	bro5	NOUN
admet-2334	235	26	compounds	compound	NOUN
admet-2334	235	27	,	,	PUNCT
admet-2334	235	28	respectively	respectively	ADV
admet-2334	235	29	)	)	PUNCT
admet-2334	235	30	.	.	PUNCT
admet-2334	236	1	experimental	experimental	ADJ
admet-2334	236	2	lipophilicity	lipophilicity	NOUN
admet-2334	236	3	(	(	PUNCT
admet-2334	236	4	brlogd	brlogd	NOUN
admet-2334	236	5	and	and	CCONJ
admet-2334	236	6	log	log	VERB
admet-2334	236	7	kw	kw	PROPN
admet-2334	236	8	iam	iam	PROPN
admet-2334	236	9	)	)	PUNCT
admet-2334	236	10	was	be	AUX
admet-2334	236	11	measured	measure	VERB
admet-2334	236	12	(	(	PUNCT
admet-2334	236	13	table	table	NOUN
admet-2334	236	14	2	2	NUM
admet-2334	236	15	)	)	PUNCT
admet-2334	236	16	.	.	PUNCT
admet-2334	237	1	arv-110	arv-110	PROPN
admet-2334	237	2	was	be	AUX
admet-2334	237	3	found	find	VERB
admet-2334	237	4	to	to	PART
admet-2334	237	5	be	be	AUX
admet-2334	237	6	slightly	slightly	ADV
admet-2334	237	7	more	more	ADV
admet-2334	237	8	polar	polar	ADJ
admet-2334	237	9	and	and	CCONJ
admet-2334	237	10	less	less	ADV
admet-2334	237	11	lipophilic	lipophilic	ADJ
admet-2334	237	12	than	than	ADP
admet-2334	237	13	arv-471	arv-471	NOUN
admet-2334	237	14	.	.	PUNCT
admet-2334	238	1	notably	notably	ADV
admet-2334	238	2	,	,	PUNCT
admet-2334	238	3	both	both	DET
admet-2334	238	4	protacs	protac	NOUN
admet-2334	238	5	seem	seem	VERB
admet-2334	238	6	to	to	PART
admet-2334	238	7	have	have	VERB
admet-2334	238	8	a	a	DET
admet-2334	238	9	rather	rather	ADV
admet-2334	238	10	similar	similar	ADJ
admet-2334	238	11	brlogd	brlogd	NOUN
admet-2334	238	12	and	and	CCONJ
admet-2334	238	13	log	log	PROPN
admet-2334	238	14	kw	kw	PROPN
admet-2334	238	15	iam	iam	PROPN
admet-2334	238	16	profile	profile	NOUN
admet-2334	238	17	,	,	PUNCT
admet-2334	238	18	revealing	reveal	VERB
admet-2334	238	19	a	a	DET
admet-2334	238	20	similar	similar	ADJ
admet-2334	238	21	physicochemical	physicochemical	ADJ
admet-2334	238	22	behaviour	behaviour	NOUN
admet-2334	238	23	(	(	PUNCT
admet-2334	238	24	despite	despite	SCONJ
admet-2334	238	25	their	their	PRON
admet-2334	238	26	different	different	ADJ
admet-2334	238	27	calculated	calculated	ADJ
admet-2334	238	28	polarity	polarity	NOUN
admet-2334	238	29	,	,	PUNCT
admet-2334	238	30	tpsa	tpsa	PROPN
admet-2334	238	31	)	)	PUNCT
admet-2334	238	32	.	.	PUNCT
admet-2334	239	1	in	in	ADP
admet-2334	239	2	addition	addition	NOUN
admet-2334	239	3	,	,	PUNCT
admet-2334	239	4	both	both	DET
admet-2334	239	5	compounds	compound	NOUN
admet-2334	239	6	behave	behave	VERB
admet-2334	239	7	as	as	ADP
admet-2334	239	8	molecular	molecular	ADJ
admet-2334	239	9	chameleons	chameleon	NOUN
admet-2334	239	10	(	(	PUNCT
admet-2334	239	11	chamelog	chamelog	NOUN
admet-2334	239	12	k	k	PROPN
admet-2334	239	13	>	>	X
admet-2334	239	14	0.6	0.6	NUM
admet-2334	239	15	)	)	PUNCT
admet-2334	239	16	,	,	PUNCT
admet-2334	239	17	being	be	AUX
admet-2334	239	18	arv-471	arv-471	ADV
admet-2334	239	19	more	more	ADV
admet-2334	239	20	chameleonic	chameleonic	ADJ
admet-2334	239	21	.	.	PUNCT
admet-2334	240	1	on	on	ADP
admet-2334	240	2	the	the	DET
admet-2334	240	3	other	other	ADJ
admet-2334	240	4	hand	hand	NOUN
admet-2334	240	5	,	,	PUNCT
admet-2334	240	6	dt2216	dt2216	PROPN
admet-2334	240	7	has	have	VERB
admet-2334	240	8	a	a	DET
admet-2334	240	9	brlogd	brlogd	NOUN
admet-2334	240	10	over	over	ADP
admet-2334	240	11	6	6	NUM
admet-2334	240	12	,	,	PUNCT
admet-2334	240	13	which	which	PRON
admet-2334	240	14	confirms	confirm	VERB
admet-2334	240	15	its	its	PRON
admet-2334	240	16	extremely	extremely	ADV
admet-2334	240	17	high	high	ADJ
admet-2334	240	18	lipophilicity	lipophilicity	NOUN
admet-2334	240	19	.	.	PUNCT
admet-2334	241	1	table	table	NOUN
admet-2334	241	2	2	2	NUM
admet-2334	241	3	.	.	PUNCT
admet-2334	241	4	physicochemical	physicochemical	ADJ
admet-2334	241	5	descriptors	descriptor	NOUN
admet-2334	241	6	obtained	obtain	VERB
admet-2334	241	7	by	by	ADP
admet-2334	241	8	chromatographic	chromatographic	ADJ
admet-2334	241	9	data	datum	NOUN
admet-2334	241	10	.	.	PUNCT
admet-2334	242	1	a	a	DET
admet-2334	242	2	/	/	SYM
admet-2334	242	3	b	b	NOUN
admet-2334	242	4	:	:	PUNCT
admet-2334	242	5	acid	acid	ADJ
admet-2334	242	6	or	or	CCONJ
admet-2334	242	7	base	base	NOUN
admet-2334	242	8	profile	profile	NOUN
admet-2334	242	9	.	.	PUNCT
admet-2334	243	1	nd	nd	NOUN
admet-2334	243	2	:	:	PUNCT
admet-2334	243	3	not	not	PART
admet-2334	243	4	determined	determine	VERB
admet-2334	243	5	.	.	PUNCT
admet-2334	244	1	compound	compound	NOUN
admet-2334	244	2	absorption	absorption	NOUN
admet-2334	244	3	a	a	PROPN
admet-2334	244	4	/	/	SYM
admet-2334	244	5	b	b	NOUN
admet-2334	244	6	br	br	NOUN
admet-2334	244	7	log	log	NOUN
admet-2334	244	8	d	d	NOUN
admet-2334	244	9	log	log	NOUN
admet-2334	245	1	kw	kw	PROPN
admet-2334	245	2	iam	iam	PROPN
admet-2334	245	3			PROPN
admet-2334	245	4	log	log	VERB
admet-2334	245	5	kw	kw	INTJ
admet-2334	245	6	iam	iam	PROPN
admet-2334	245	7	chamelogk	chamelogk	ADJ
admet-2334	245	8	arv-110	arv-110	PROPN
admet-2334	245	9	oral	oral	ADJ
admet-2334	245	10	base	base	NOUN
admet-2334	245	11	4.25	4.25	NUM
admet-2334	245	12	3.20	3.20	NUM
admet-2334	245	13	0.33	0.33	NUM
admet-2334	245	14	0.99	0.99	NUM
admet-2334	245	15	arv-471	arv-471	NOUN
admet-2334	245	16	oral	oral	ADJ
admet-2334	245	17	base	base	NOUN
admet-2334	245	18	4.73	4.73	NUM
admet-2334	245	19	3.39	3.39	NUM
admet-2334	245	20	0.07	0.07	NUM
admet-2334	245	21	1.35	1.35	NUM
admet-2334	245	22	dt2216	dt2216	PROPN
admet-2334	245	23	intravenous	intravenous	ADJ
admet-2334	245	24	ampholite	ampholite	ADJ
admet-2334	245	25	>	>	X
admet-2334	245	26	6	6	NUM
admet-2334	245	27	>	>	SYM
admet-2334	245	28	4	4	NUM
admet-2334	245	29	nd	nd	NOUN
admet-2334	245	30	nd	nd	NUM
admet-2334	245	31	admet	admet	PROPN
admet-2334	245	32	&	&	CCONJ
admet-2334	245	33	dmpk	dmpk	PROPN
admet-2334	245	34	12(5	12(5	NUM
admet-2334	245	35	)	)	PUNCT
admet-2334	245	36	(	(	PUNCT
admet-2334	245	37	2024	2024	NUM
admet-2334	245	38	)	)	PUNCT
admet-2334	245	39	721	721	NUM
admet-2334	245	40	-	-	NUM
admet-2334	245	41	736	736	NUM
admet-2334	245	42	designing	design	VERB
admet-2334	245	43	the	the	DET
admet-2334	245	44	next	next	ADJ
admet-2334	245	45	generation	generation	NOUN
admet-2334	245	46	of	of	ADP
admet-2334	245	47	oral	oral	ADJ
admet-2334	245	48	beyond	beyond	ADP
admet-2334	245	49	rule	rule	NOUN
admet-2334	245	50	of	of	ADP
admet-2334	245	51	five	five	NUM
admet-2334	245	52	drugs	drug	NOUN
admet-2334	245	53	doi	doi	NOUN
admet-2334	245	54	:	:	PUNCT
admet-2334	245	55	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	NOUN
admet-2334	245	56	731	731	NUM
admet-2334	245	57	as	as	ADV
admet-2334	245	58	proven	prove	VERB
admet-2334	245	59	earlier	early	ADV
admet-2334	245	60	[	[	X
admet-2334	245	61	40	40	NUM
admet-2334	245	62	]	]	PUNCT
admet-2334	245	63	,	,	PUNCT
admet-2334	245	64	brlogd	brlogd	NOUN
admet-2334	245	65	and	and	CCONJ
admet-2334	245	66	log	log	PROPN
admet-2334	245	67	kw	kw	PROPN
admet-2334	245	68	iam	iam	PROPN
admet-2334	245	69	are	be	AUX
admet-2334	245	70	useful	useful	ADJ
admet-2334	245	71	descriptors	descriptor	NOUN
admet-2334	245	72	to	to	PART
admet-2334	245	73	simultaneously	simultaneously	ADV
admet-2334	245	74	monitor	monitor	VERB
admet-2334	245	75	the	the	DET
admet-2334	245	76	lipophilicity	lipophilicity	NOUN
admet-2334	245	77	/	/	SYM
admet-2334	245	78	polarity	polarity	NOUN
admet-2334	245	79	balance	balance	NOUN
admet-2334	245	80	of	of	ADP
admet-2334	245	81	bro5	bro5	NOUN
admet-2334	245	82	compounds	compound	NOUN
admet-2334	245	83	.	.	PUNCT
admet-2334	246	1	in	in	ADP
admet-2334	246	2	particular	particular	ADJ
admet-2334	246	3	,	,	PUNCT
admet-2334	246	4	this	this	DET
admet-2334	246	5	balance	balance	NOUN
admet-2334	246	6	was	be	AUX
admet-2334	246	7	proven	prove	VERB
admet-2334	246	8	helpful	helpful	ADJ
admet-2334	246	9	in	in	ADP
admet-2334	246	10	rationalizing	rationalize	VERB
admet-2334	246	11	the	the	DET
admet-2334	246	12	absorption	absorption	NOUN
admet-2334	246	13	route	route	NOUN
admet-2334	246	14	of	of	ADP
admet-2334	246	15	several	several	ADJ
admet-2334	246	16	bro5	bro5	NOUN
admet-2334	246	17	examples	example	NOUN
admet-2334	246	18	.	.	PUNCT
admet-2334	247	1	we	we	PRON
admet-2334	247	2	incorporated	incorporate	VERB
admet-2334	247	3	the	the	DET
admet-2334	247	4	experimental	experimental	ADJ
admet-2334	247	5	data	datum	NOUN
admet-2334	247	6	of	of	ADP
admet-2334	247	7	the	the	DET
admet-2334	247	8	three	three	NUM
admet-2334	247	9	investigated	investigate	VERB
admet-2334	247	10	protacs	protac	NOUN
admet-2334	247	11	into	into	ADP
admet-2334	247	12	the	the	DET
admet-2334	247	13	originally	originally	ADV
admet-2334	247	14	published	publish	VERB
admet-2334	247	15	plot	plot	NOUN
admet-2334	247	16	[	[	X
admet-2334	247	17	40	40	NUM
admet-2334	247	18	]	]	PUNCT
admet-2334	247	19	and	and	CCONJ
admet-2334	247	20	observed	observe	VERB
admet-2334	247	21	that	that	SCONJ
admet-2334	247	22	the	the	DET
admet-2334	247	23	trend	trend	NOUN
admet-2334	247	24	is	be	AUX
admet-2334	247	25	maintained	maintain	VERB
admet-2334	247	26	(	(	PUNCT
admet-2334	247	27	figure	figure	NOUN
admet-2334	247	28	9	9	NUM
admet-2334	247	29	)	)	PUNCT
admet-2334	247	30	.	.	PUNCT
admet-2334	248	1	arv-110	arv-110	PROPN
admet-2334	248	2	and	and	CCONJ
admet-2334	248	3	arv-471	arv-471	NOUN
admet-2334	248	4	occupy	occupy	VERB
admet-2334	248	5	an	an	DET
admet-2334	248	6	intermediate	intermediate	ADJ
admet-2334	248	7	position	position	NOUN
admet-2334	248	8	in	in	ADP
admet-2334	248	9	terms	term	NOUN
admet-2334	248	10	of	of	ADP
admet-2334	248	11	lipophilicity	lipophilicity	NOUN
admet-2334	248	12	and	and	CCONJ
admet-2334	248	13	polarity	polarity	NOUN
admet-2334	248	14	,	,	PUNCT
admet-2334	248	15	aligning	align	VERB
admet-2334	248	16	with	with	ADP
admet-2334	248	17	other	other	ADJ
admet-2334	248	18	oral	oral	ADJ
admet-2334	248	19	compounds	compound	NOUN
admet-2334	248	20	.	.	PUNCT
admet-2334	249	1	notably	notably	ADV
admet-2334	249	2	,	,	PUNCT
admet-2334	249	3	both	both	PRON
admet-2334	249	4	are	be	AUX
admet-2334	249	5	less	less	ADV
admet-2334	249	6	polar	polar	ADJ
admet-2334	249	7	and	and	CCONJ
admet-2334	249	8	more	more	ADJ
admet-2334	249	9	lipophilic	lipophilic	ADJ
admet-2334	249	10	than	than	ADP
admet-2334	249	11	arv-825	arv-825	PROPN
admet-2334	249	12	,	,	PUNCT
admet-2334	249	13	another	another	DET
admet-2334	249	14	oral	oral	ADJ
admet-2334	249	15	crbn	crbn	NOUN
admet-2334	249	16	-	-	PUNCT
admet-2334	249	17	based	base	VERB
admet-2334	249	18	degrader	degrader	NOUN
admet-2334	249	19	.	.	PUNCT
admet-2334	250	1	furthermore	furthermore	ADV
admet-2334	250	2	,	,	PUNCT
admet-2334	250	3	the	the	DET
admet-2334	250	4	high	high	ADJ
admet-2334	250	5	lipophilicity	lipophilicity	NOUN
admet-2334	250	6	and	and	CCONJ
admet-2334	250	7	the	the	DET
admet-2334	250	8	presumed	presume	VERB
admet-2334	250	9	low	low	ADJ
admet-2334	250	10	polarity	polarity	NOUN
admet-2334	250	11	of	of	ADP
admet-2334	250	12	ddt2216	ddt2216	NOUN
admet-2334	250	13	places	place	VERB
admet-2334	250	14	it	it	PRON
admet-2334	250	15	outside	outside	ADP
admet-2334	250	16	the	the	DET
admet-2334	250	17	delimited	delimit	VERB
admet-2334	250	18	oral	oral	ADJ
admet-2334	250	19	zone	zone	NOUN
admet-2334	250	20	.	.	PUNCT
admet-2334	251	1	these	these	DET
admet-2334	251	2	results	result	NOUN
admet-2334	251	3	provide	provide	VERB
admet-2334	251	4	further	further	ADJ
admet-2334	251	5	support	support	NOUN
admet-2334	251	6	for	for	ADP
admet-2334	251	7	the	the	DET
admet-2334	251	8	assertion	assertion	NOUN
admet-2334	251	9	that	that	SCONJ
admet-2334	251	10	the	the	DET
admet-2334	251	11	experimental	experimental	ADJ
admet-2334	251	12	measurement	measurement	NOUN
admet-2334	251	13	of	of	ADP
admet-2334	251	14	molecular	molecular	ADJ
admet-2334	251	15	properties	property	NOUN
admet-2334	251	16	is	be	AUX
admet-2334	251	17	a	a	DET
admet-2334	251	18	mandatory	mandatory	ADJ
admet-2334	251	19	part	part	NOUN
admet-2334	251	20	of	of	ADP
admet-2334	251	21	any	any	DET
admet-2334	251	22	bro5	bro5	NOUN
admet-2334	251	23	drug	drug	NOUN
admet-2334	251	24	discovery	discovery	PROPN
admet-2334	251	25	program	program	NOUN
admet-2334	251	26	.	.	PUNCT
admet-2334	252	1	figure	figure	NOUN
admet-2334	252	2	9	9	NUM
admet-2334	252	3	.	.	PUNCT
admet-2334	253	1	polarity	polarity	NOUN
admet-2334	253	2	and	and	CCONJ
admet-2334	253	3	lipophilicity	lipophilicity	NOUN
admet-2334	253	4	balance	balance	NOUN
admet-2334	253	5	for	for	ADP
admet-2334	253	6	a	a	DET
admet-2334	253	7	set	set	NOUN
admet-2334	253	8	of	of	ADP
admet-2334	253	9	bro5	bro5	NOUN
admet-2334	253	10	compounds	compound	NOUN
admet-2334	253	11	with	with	ADP
admet-2334	253	12	respect	respect	NOUN
admet-2334	253	13	to	to	ADP
admet-2334	253	14	their	their	PRON
admet-2334	253	15	absorption	absorption	NOUN
admet-2334	253	16	routes.[40	routes.[40	NOUN
admet-2334	253	17	]	]	PUNCT
admet-2334	253	18	the	the	DET
admet-2334	253	19	position	position	NOUN
admet-2334	253	20	of	of	ADP
admet-2334	253	21	arv-110	arv-110	PROPN
admet-2334	253	22	,	,	PUNCT
admet-2334	253	23	arv-471	arv-471	NOUN
admet-2334	253	24	and	and	CCONJ
admet-2334	253	25	ddt2216	ddt2216	NOUN
admet-2334	253	26	positions	position	NOUN
admet-2334	253	27	is	be	AUX
admet-2334	253	28	highlighted	highlight	VERB
admet-2334	253	29	.	.	PUNCT
admet-2334	254	1	other	other	ADJ
admet-2334	254	2	benchmarking	benchmarke	VERB
admet-2334	254	3	compounds	compound	NOUN
admet-2334	254	4	are	be	AUX
admet-2334	254	5	presented	present	VERB
admet-2334	254	6	in	in	ADP
admet-2334	254	7	italics	italic	NOUN
admet-2334	254	8	(	(	PUNCT
admet-2334	254	9	macrocycles	macrocycle	NOUN
admet-2334	254	10	)	)	PUNCT
admet-2334	254	11	and	and	CCONJ
admet-2334	254	12	regular	regular	ADJ
admet-2334	254	13	font	font	NOUN
admet-2334	254	14	(	(	PUNCT
admet-2334	254	15	protacs	protacs	PROPN
admet-2334	254	16	)	)	PUNCT
admet-2334	254	17	.	.	PUNCT
admet-2334	255	1	the	the	DET
admet-2334	255	2	x	x	PROPN
admet-2334	255	3	value	value	NOUN
admet-2334	255	4	of	of	ADP
admet-2334	255	5	dt2216	dt2216	PROPN
admet-2334	255	6	is	be	AUX
admet-2334	255	7	presented	present	VERB
admet-2334	255	8	as	as	ADP
admet-2334	255	9	relative	relative	ADJ
admet-2334	255	10	since	since	SCONJ
admet-2334	255	11	the	the	DET
admet-2334	255	12			NOUN
admet-2334	255	13	log	log	NOUN
admet-2334	255	14	kw	kw	PROPN
admet-2334	255	15	iam	iam	PROPN
admet-2334	255	16	descriptor	descriptor	NOUN
admet-2334	255	17	is	be	AUX
admet-2334	255	18	inaccurate	inaccurate	ADJ
admet-2334	255	19	for	for	ADP
admet-2334	255	20	ampholytes	ampholyte	NOUN
admet-2334	255	21	.	.	PUNCT
admet-2334	256	1	as	as	SCONJ
admet-2334	256	2	already	already	ADV
admet-2334	256	3	mentioned	mention	VERB
admet-2334	256	4	,	,	PUNCT
admet-2334	256	5	it	it	PRON
admet-2334	256	6	is	be	AUX
admet-2334	256	7	essential	essential	ADJ
admet-2334	256	8	to	to	PART
admet-2334	256	9	have	have	VERB
admet-2334	256	10	simple	simple	ADJ
admet-2334	256	11	computational	computational	ADJ
admet-2334	256	12	tools	tool	NOUN
admet-2334	256	13	that	that	PRON
admet-2334	256	14	can	can	AUX
admet-2334	256	15	predict	predict	VERB
admet-2334	256	16	molecular	molecular	ADJ
admet-2334	256	17	chameleonicity	chameleonicity	NOUN
admet-2334	256	18	in	in	ADP
admet-2334	256	19	early	early	ADJ
admet-2334	256	20	drug	drug	NOUN
admet-2334	256	21	design	design	NOUN
admet-2334	256	22	to	to	PART
admet-2334	256	23	prioritize	prioritize	VERB
admet-2334	256	24	the	the	DET
admet-2334	256	25	synthesis	synthesis	NOUN
admet-2334	256	26	of	of	ADP
admet-2334	256	27	derivatives	derivative	NOUN
admet-2334	256	28	with	with	ADP
admet-2334	256	29	the	the	DET
admet-2334	256	30	desired	desire	VERB
admet-2334	256	31	physicochemical	physicochemical	ADJ
admet-2334	256	32	profile	profile	NOUN
admet-2334	256	33	.	.	PUNCT
admet-2334	257	1	thus	thus	ADV
admet-2334	257	2	,	,	PUNCT
admet-2334	257	3	conformational	conformational	ADJ
admet-2334	257	4	sampling	sampling	NOUN
admet-2334	257	5	simulations	simulation	NOUN
admet-2334	257	6	in	in	ADP
admet-2334	257	7	water	water	NOUN
admet-2334	257	8	and	and	CCONJ
admet-2334	257	9	chloroform	chloroform	NOUN
admet-2334	257	10	were	be	AUX
admet-2334	257	11	conducted	conduct	VERB
admet-2334	257	12	only	only	ADV
admet-2334	257	13	for	for	ADP
admet-2334	257	14	arv110	arv110	PROPN
admet-2334	257	15	and	and	CCONJ
admet-2334	257	16	arv-471	arv-471	NOUN
admet-2334	257	17	,	,	PUNCT
admet-2334	257	18	as	as	SCONJ
admet-2334	257	19	the	the	DET
admet-2334	257	20	complex	complex	ADJ
admet-2334	257	21	ionization	ionization	NOUN
admet-2334	257	22	profile	profile	NOUN
admet-2334	257	23	of	of	ADP
admet-2334	257	24	dt2216	dt2216	PROPN
admet-2334	257	25	precludes	preclude	VERB
admet-2334	257	26	this	this	DET
admet-2334	257	27	type	type	NOUN
admet-2334	257	28	of	of	ADP
admet-2334	257	29	analysis	analysis	NOUN
admet-2334	257	30	.	.	PUNCT
admet-2334	258	1	two	two	NUM
admet-2334	258	2	conformational	conformational	ADJ
admet-2334	258	3	sampling	sampling	NOUN
admet-2334	258	4	methodologies	methodology	NOUN
admet-2334	258	5	(	(	PUNCT
admet-2334	258	6	macromodel	macromodel	NOUN
admet-2334	258	7	and	and	CCONJ
admet-2334	258	8	vega	vega	PROPN
admet-2334	258	9	zz	zz	PROPN
admet-2334	258	10	)	)	PUNCT
admet-2334	258	11	were	be	AUX
admet-2334	258	12	evaluated	evaluate	VERB
admet-2334	258	13	.	.	PUNCT
admet-2334	259	1	the	the	DET
admet-2334	259	2	former	former	ADJ
admet-2334	259	3	is	be	AUX
admet-2334	259	4	a	a	DET
admet-2334	259	5	cs	cs	ADJ
admet-2334	259	6	tool	tool	NOUN
admet-2334	259	7	implementing	implement	VERB
admet-2334	259	8	the	the	DET
admet-2334	259	9	mixed	mixed	ADJ
admet-2334	259	10	model	model	NOUN
admet-2334	259	11	algorithm	algorithm	NOUN
admet-2334	259	12	(	(	PUNCT
admet-2334	259	13	mcmm	mcmm	NOUN
admet-2334	259	14	/	/	SYM
admet-2334	259	15	lmod	lmod	NOUN
admet-2334	259	16	)	)	PUNCT
admet-2334	259	17	already	already	ADV
admet-2334	259	18	benchmarked	benchmarke	VERB
admet-2334	259	19	for	for	ADP
admet-2334	259	20	several	several	ADJ
admet-2334	259	21	protacs	protac	NOUN
admet-2334	259	22	[	[	X
admet-2334	259	23	48	48	NUM
admet-2334	259	24	]	]	PUNCT
admet-2334	259	25	.	.	PUNCT
admet-2334	260	1	vega	vega	PROPN
admet-2334	260	2	zz	zz	PROPN
admet-2334	260	3	adopts	adopt	VERB
admet-2334	260	4	an	an	DET
admet-2334	260	5	alternative	alternative	ADJ
admet-2334	260	6	conformational	conformational	ADJ
admet-2334	260	7	search	search	NOUN
admet-2334	260	8	method	method	NOUN
admet-2334	260	9	based	base	VERB
admet-2334	260	10	on	on	ADP
admet-2334	260	11	the	the	DET
admet-2334	260	12	“	"	PUNCT
admet-2334	260	13	boltzmann	boltzmann	PROPN
admet-2334	260	14	jump	jump	NOUN
admet-2334	260	15	”	"	PUNCT
admet-2334	260	16	method	method	NOUN
admet-2334	260	17	.	.	PUNCT
admet-2334	261	1	results	result	NOUN
admet-2334	261	2	are	be	AUX
admet-2334	261	3	shown	show	VERB
admet-2334	261	4	in	in	ADP
admet-2334	261	5	figure	figure	NOUN
admet-2334	261	6	10	10	NUM
admet-2334	261	7	(	(	PUNCT
admet-2334	261	8	figure	figure	NOUN
admet-2334	261	9	6	6	NUM
admet-2334	261	10	helps	help	VERB
admet-2334	261	11	in	in	ADP
admet-2334	261	12	the	the	DET
admet-2334	261	13	plot	plot	NOUN
admet-2334	261	14	interpretation	interpretation	NOUN
admet-2334	261	15	)	)	PUNCT
admet-2334	261	16	.	.	PUNCT
admet-2334	262	1	arv-110	arv-110	PROPN
admet-2334	262	2	and	and	CCONJ
admet-2334	262	3	arv-471	arv-471	NOUN
admet-2334	262	4	were	be	AUX
admet-2334	262	5	analyzed	analyze	VERB
admet-2334	262	6	and	and	CCONJ
admet-2334	262	7	easily	easily	ADV
admet-2334	262	8	compared	compare	VERB
admet-2334	262	9	,	,	PUNCT
admet-2334	262	10	given	give	VERB
admet-2334	262	11	their	their	PRON
admet-2334	262	12	shared	share	VERB
admet-2334	262	13	e3	e3	NOUN
admet-2334	262	14	ligand	ligand	NOUN
admet-2334	262	15	-	-	PUNCT
admet-2334	262	16	linker	linker	NOUN
admet-2334	262	17	structure	structure	NOUN
admet-2334	262	18	(	(	PUNCT
admet-2334	262	19	figure	figure	NOUN
admet-2334	262	20	7	7	NUM
admet-2334	262	21	)	)	PUNCT
admet-2334	262	22	.	.	PUNCT
admet-2334	263	1	the	the	DET
admet-2334	263	2	rgyr	rgyr	NOUN
admet-2334	263	3	vs.	vs.	X
admet-2334	263	4	3d	3d	PROPN
admet-2334	263	5	psa	psa	NOUN
admet-2334	263	6	plots	plot	NOUN
admet-2334	263	7	(	(	PUNCT
admet-2334	263	8	figure	figure	NOUN
admet-2334	263	9	10a	10a	NOUN
admet-2334	263	10	)	)	PUNCT
admet-2334	263	11	suggest	suggest	VERB
admet-2334	263	12	that	that	SCONJ
admet-2334	263	13	vega	vega	PROPN
admet-2334	263	14	zz	zz	PROPN
admet-2334	263	15	provides	provide	VERB
admet-2334	263	16	a	a	DET
admet-2334	263	17	generous	generous	ADJ
admet-2334	263	18	number	number	NOUN
admet-2334	263	19	of	of	ADP
admet-2334	263	20	conformers	conformer	NOUN
admet-2334	263	21	in	in	ADP
admet-2334	263	22	aqueous	aqueous	ADJ
admet-2334	263	23	and	and	CCONJ
admet-2334	263	24	chloroform	chloroform	NOUN
admet-2334	263	25	environments	environment	NOUN
admet-2334	263	26	,	,	PUNCT
admet-2334	263	27	but	but	CCONJ
admet-2334	263	28	the	the	DET
admet-2334	263	29	environment	environment	NOUN
admet-2334	263	30	-	-	PUNCT
admet-2334	263	31	dependent	dependent	ADJ
admet-2334	263	32	differences	difference	NOUN
admet-2334	263	33	are	be	AUX
admet-2334	263	34	difficult	difficult	ADJ
admet-2334	263	35	to	to	PART
admet-2334	263	36	identify	identify	VERB
admet-2334	263	37	.	.	PUNCT
admet-2334	264	1	macromodel	macromodel	PROPN
admet-2334	264	2	,	,	PUNCT
admet-2334	264	3	on	on	ADP
admet-2334	264	4	the	the	DET
admet-2334	264	5	other	other	ADJ
admet-2334	264	6	hand	hand	NOUN
admet-2334	264	7	,	,	PUNCT
admet-2334	264	8	provides	provide	VERB
admet-2334	264	9	solvent	solvent	NOUN
admet-2334	264	10	-	-	PUNCT
admet-2334	264	11	dependent	dependent	ADJ
admet-2334	264	12	conformations	conformation	NOUN
admet-2334	264	13	with	with	ADP
admet-2334	264	14	different	different	ADJ
admet-2334	264	15	polarity	polarity	NOUN
admet-2334	264	16	and	and	CCONJ
admet-2334	264	17	shape	shape	NOUN
admet-2334	264	18	characteristics	characteristic	NOUN
admet-2334	264	19	for	for	ADP
admet-2334	264	20	the	the	DET
admet-2334	264	21	two	two	NUM
admet-2334	264	22	protacs	protac	NOUN
admet-2334	264	23	.	.	PUNCT
admet-2334	265	1	in	in	ADP
admet-2334	265	2	fact	fact	NOUN
admet-2334	265	3	,	,	PUNCT
admet-2334	265	4	both	both	DET
admet-2334	265	5	compounds	compound	NOUN
admet-2334	265	6	show	show	VERB
admet-2334	265	7	less	less	ADJ
admet-2334	265	8	polar	polar	ADJ
admet-2334	265	9	conformations	conformation	NOUN
admet-2334	265	10	in	in	ADP
admet-2334	265	11	chloroform	chloroform	NOUN
admet-2334	265	12	,	,	PUNCT
admet-2334	265	13	which	which	PRON
admet-2334	265	14	suggests	suggest	VERB
admet-2334	265	15	a	a	DET
admet-2334	265	16	chameleonic	chameleonic	ADJ
admet-2334	265	17	nature	nature	NOUN
admet-2334	265	18	.	.	PUNCT
admet-2334	266	1	moreover	moreover	ADV
admet-2334	266	2	,	,	PUNCT
admet-2334	266	3	arv-471	arv-471	NOUN
admet-2334	266	4	is	be	AUX
admet-2334	266	5	considerably	considerably	ADV
admet-2334	266	6	more	more	ADV
admet-2334	266	7	variable	variable	ADJ
admet-2334	266	8	in	in	ADP
admet-2334	266	9	terms	term	NOUN
admet-2334	266	10	of	of	ADP
admet-2334	266	11	rgyr	rgyr	NOUN
admet-2334	266	12	than	than	ADP
admet-2334	266	13	arv-110	arv-110	PROPN
admet-2334	266	14	,	,	PUNCT
admet-2334	266	15	displaying	display	VERB
admet-2334	266	16	a	a	DET
admet-2334	266	17	higher	high	ADJ
admet-2334	266	18	conformational	conformational	ADJ
admet-2334	266	19	variability	variability	NOUN
admet-2334	266	20	,	,	PUNCT
admet-2334	266	21	which	which	PRON
admet-2334	266	22	could	could	AUX
admet-2334	266	23	be	be	AUX
admet-2334	266	24	related	relate	VERB
admet-2334	266	25	to	to	ADP
admet-2334	266	26	the	the	DET
admet-2334	266	27	higher	high	ADJ
admet-2334	266	28	chameleonicity	chameleonicity	NOUN
admet-2334	266	29	.	.	PUNCT
admet-2334	267	1	the	the	DET
admet-2334	267	2	minimum	minimum	ADJ
admet-2334	267	3	energy	energy	NOUN
admet-2334	267	4	conformers	conformer	NOUN
admet-2334	267	5	(	(	PUNCT
admet-2334	267	6	mecs	mecs	PROPN
admet-2334	267	7	)	)	PUNCT
admet-2334	267	8	do	do	AUX
admet-2334	267	9	not	not	PART
admet-2334	267	10	provide	provide	VERB
admet-2334	267	11	additional	additional	ADJ
admet-2334	267	12	information	information	NOUN
admet-2334	267	13	with	with	ADP
admet-2334	267	14	either	either	DET
admet-2334	267	15	tool	tool	NOUN
admet-2334	267	16	.	.	PUNCT
admet-2334	268	1	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	268	2	d.	d.	PROPN
admet-2334	268	3	g.	g.	PROPN
admet-2334	268	4	jiménez	jiménez	PROPN
admet-2334	268	5	et	et	PROPN
admet-2334	268	6	al	al	PROPN
admet-2334	268	7	.	.	PROPN
admet-2334	268	8	admet	admet	PROPN
admet-2334	268	9	&	&	CCONJ
admet-2334	268	10	dmpk	dmpk	PROPN
admet-2334	268	11	12(5	12(5	NUM
admet-2334	268	12	)	)	PUNCT
admet-2334	268	13	(	(	PUNCT
admet-2334	268	14	2024	2024	NUM
admet-2334	268	15	)	)	PUNCT
admet-2334	268	16	721	721	NUM
admet-2334	268	17	-	-	NUM
admet-2334	268	18	736	736	NUM
admet-2334	268	19	732	732	NUM
admet-2334	268	20	figure	figure	NOUN
admet-2334	268	21	10	10	NUM
admet-2334	268	22	.	.	PUNCT
admet-2334	269	1	chameleonicity	chameleonicity	NOUN
admet-2334	269	2	prediction	prediction	NOUN
admet-2334	269	3	for	for	ADP
admet-2334	269	4	the	the	DET
admet-2334	269	5	investigated	investigate	VERB
admet-2334	269	6	compounds	compound	NOUN
admet-2334	269	7	.	.	PUNCT
admet-2334	270	1	the	the	DET
admet-2334	270	2	minimum	minimum	ADJ
admet-2334	270	3	energy	energy	NOUN
admet-2334	270	4	conformers	conformer	NOUN
admet-2334	270	5	(	(	PUNCT
admet-2334	270	6	mecs	mecs	PROPN
admet-2334	270	7	)	)	PUNCT
admet-2334	270	8	are	be	AUX
admet-2334	270	9	shown	show	VERB
admet-2334	270	10	as	as	ADP
admet-2334	270	11	triangles	triangle	NOUN
admet-2334	270	12	colored	color	VERB
admet-2334	270	13	in	in	ADP
admet-2334	270	14	gold	gold	NOUN
admet-2334	270	15	(	(	PUNCT
admet-2334	270	16	chloroform	chloroform	NOUN
admet-2334	270	17	)	)	PUNCT
admet-2334	270	18	and	and	CCONJ
admet-2334	270	19	light	light	ADJ
admet-2334	270	20	blue	blue	ADJ
admet-2334	270	21	(	(	PUNCT
admet-2334	270	22	water	water	NOUN
admet-2334	270	23	)	)	PUNCT
admet-2334	270	24	.	.	PUNCT
admet-2334	271	1	3d	3d	NUM
admet-2334	271	2	strategies	strategy	NOUN
admet-2334	271	3	were	be	AUX
admet-2334	271	4	not	not	PART
admet-2334	271	5	applied	apply	VERB
admet-2334	271	6	to	to	ADP
admet-2334	271	7	dt2216	dt2216	PROPN
admet-2334	271	8	due	due	ADP
admet-2334	271	9	to	to	ADP
admet-2334	271	10	its	its	PRON
admet-2334	271	11	complex	complex	ADJ
admet-2334	271	12	ionization	ionization	NOUN
admet-2334	271	13	profile	profile	NOUN
admet-2334	271	14	.	.	PUNCT
admet-2334	272	1	conclusions	conclusion	NOUN
admet-2334	272	2	new	new	ADJ
admet-2334	272	3	chemical	chemical	NOUN
admet-2334	272	4	modalities	modality	NOUN
admet-2334	272	5	are	be	AUX
admet-2334	272	6	gaining	gain	VERB
admet-2334	272	7	popularity	popularity	NOUN
admet-2334	272	8	in	in	ADP
admet-2334	272	9	drug	drug	NOUN
admet-2334	272	10	discovery	discovery	NOUN
admet-2334	272	11	due	due	ADP
admet-2334	272	12	to	to	ADP
admet-2334	272	13	their	their	PRON
admet-2334	272	14	innovative	innovative	ADJ
admet-2334	272	15	mechanisms	mechanism	NOUN
admet-2334	272	16	of	of	ADP
admet-2334	272	17	action	action	NOUN
admet-2334	272	18	.	.	PUNCT
admet-2334	273	1	however	however	ADV
admet-2334	273	2	,	,	PUNCT
admet-2334	273	3	their	their	PRON
admet-2334	273	4	large	large	ADJ
admet-2334	273	5	and	and	CCONJ
admet-2334	273	6	flexible	flexible	ADJ
admet-2334	273	7	bro5	bro5	NOUN
admet-2334	273	8	structures	structure	NOUN
admet-2334	273	9	pose	pose	VERB
admet-2334	273	10	significant	significant	ADJ
admet-2334	273	11	dmpk	dmpk	NOUN
admet-2334	273	12	limitations	limitation	NOUN
admet-2334	273	13	.	.	PUNCT
admet-2334	274	1	to	to	PART
admet-2334	274	2	address	address	VERB
admet-2334	274	3	this	this	DET
admet-2334	274	4	challenge	challenge	NOUN
admet-2334	274	5	,	,	PUNCT
admet-2334	274	6	recent	recent	ADJ
admet-2334	274	7	literature	literature	NOUN
admet-2334	274	8	emphasizes	emphasize	VERB
admet-2334	274	9	the	the	DET
admet-2334	274	10	need	need	NOUN
admet-2334	274	11	for	for	ADP
admet-2334	274	12	efficient	efficient	ADJ
admet-2334	274	13	methods	method	NOUN
admet-2334	274	14	to	to	PART
admet-2334	274	15	quantify	quantify	VERB
admet-2334	274	16	and	and	CCONJ
admet-2334	274	17	optimize	optimize	VERB
admet-2334	274	18	physicochemical	physicochemical	ADJ
admet-2334	274	19	properties	property	NOUN
admet-2334	274	20	when	when	SCONJ
admet-2334	274	21	designing	design	VERB
admet-2334	274	22	new	new	ADJ
admet-2334	274	23	oral	oral	ADJ
admet-2334	274	24	bro5	bro5	NOUN
admet-2334	274	25	drugs	drug	NOUN
admet-2334	274	26	.	.	PUNCT
admet-2334	275	1	achieving	achieve	VERB
admet-2334	275	2	this	this	DET
admet-2334	275	3	goal	goal	NOUN
admet-2334	275	4	requires	require	VERB
admet-2334	275	5	working	work	VERB
admet-2334	275	6	at	at	ADP
admet-2334	275	7	multiple	multiple	ADJ
admet-2334	275	8	levels	level	NOUN
admet-2334	275	9	of	of	ADP
admet-2334	275	10	complexity	complexity	NOUN
admet-2334	275	11	.	.	PUNCT
admet-2334	276	1	while	while	SCONJ
admet-2334	276	2	2d	2d	NUM
admet-2334	276	3	computed	computed	ADJ
admet-2334	276	4	descriptors	descriptor	NOUN
admet-2334	276	5	are	be	AUX
admet-2334	276	6	easy	easy	ADJ
admet-2334	276	7	to	to	PART
admet-2334	276	8	obtain	obtain	VERB
admet-2334	276	9	,	,	PUNCT
admet-2334	276	10	they	they	PRON
admet-2334	276	11	fail	fail	VERB
admet-2334	276	12	to	to	PART
admet-2334	276	13	capture	capture	VERB
admet-2334	276	14	molecular	molecular	ADJ
admet-2334	276	15	properties	property	NOUN
admet-2334	276	16	influenced	influence	VERB
admet-2334	276	17	by	by	ADP
admet-2334	276	18	conformation	conformation	NOUN
admet-2334	276	19	effects	effect	NOUN
admet-2334	276	20	,	,	PUNCT
admet-2334	276	21	such	such	ADJ
admet-2334	276	22	as	as	ADP
admet-2334	276	23	imhb	imhb	ADJ
admet-2334	276	24	formation	formation	NOUN
admet-2334	276	25	.	.	PUNCT
admet-2334	277	1	therefore	therefore	ADV
admet-2334	277	2	,	,	PUNCT
admet-2334	277	3	their	their	PRON
admet-2334	277	4	extensive	extensive	ADJ
admet-2334	277	5	application	application	NOUN
admet-2334	277	6	in	in	ADP
admet-2334	277	7	advancing	advance	VERB
admet-2334	277	8	compounds	compound	NOUN
admet-2334	277	9	through	through	ADP
admet-2334	277	10	the	the	DET
admet-2334	277	11	bro5	bro5	NOUN
admet-2334	277	12	drug	drug	NOUN
admet-2334	277	13	discovery	discovery	PROPN
admet-2334	277	14	pipeline	pipeline	NOUN
admet-2334	277	15	should	should	AUX
admet-2334	277	16	be	be	AUX
admet-2334	277	17	approached	approach	VERB
admet-2334	277	18	with	with	ADP
admet-2334	277	19	caution	caution	NOUN
admet-2334	277	20	and	and	CCONJ
admet-2334	277	21	critical	critical	ADJ
admet-2334	277	22	analysis	analysis	NOUN
admet-2334	277	23	.	.	PUNCT
admet-2334	278	1	a	a	DET
admet-2334	278	2	carefully	carefully	ADV
admet-2334	278	3	chosen	choose	VERB
admet-2334	278	4	set	set	NOUN
admet-2334	278	5	of	of	ADP
admet-2334	278	6	experimental	experimental	ADJ
admet-2334	278	7	physicochemical	physicochemical	ADJ
admet-2334	278	8	descriptors	descriptor	NOUN
admet-2334	278	9	can	can	AUX
admet-2334	278	10	be	be	AUX
admet-2334	278	11	determined	determine	VERB
admet-2334	278	12	for	for	ADP
admet-2334	278	13	bro5	bro5	NOUN
admet-2334	278	14	derivatives	derivative	NOUN
admet-2334	278	15	.	.	PUNCT
admet-2334	279	1	these	these	DET
admet-2334	279	2	descriptors	descriptor	NOUN
admet-2334	279	3	can	can	AUX
admet-2334	279	4	effectively	effectively	ADV
admet-2334	279	5	characterize	characterize	VERB
admet-2334	279	6	the	the	DET
admet-2334	279	7	lipophilicity	lipophilicity	NOUN
admet-2334	279	8	,	,	PUNCT
admet-2334	279	9	polarity	polarity	NOUN
admet-2334	279	10	,	,	PUNCT
admet-2334	279	11	and	and	CCONJ
admet-2334	279	12	chameleonicity	chameleonicity	NOUN
admet-2334	279	13	(	(	PUNCT
admet-2334	279	14	the	the	DET
admet-2334	279	15	molecular	molecular	ADJ
admet-2334	279	16	property	property	NOUN
admet-2334	279	17	describing	describe	VERB
admet-2334	279	18	a	a	DET
admet-2334	279	19	compound	compound	NOUN
admet-2334	279	20	's	's	PART
admet-2334	279	21	ability	ability	NOUN
admet-2334	279	22	to	to	PART
admet-2334	279	23	undergo	undergo	VERB
admet-2334	279	24	conformational	conformational	ADJ
admet-2334	279	25	changes	change	NOUN
admet-2334	279	26	to	to	PART
admet-2334	279	27	adapt	adapt	VERB
admet-2334	279	28	to	to	ADP
admet-2334	279	29	different	different	ADJ
admet-2334	279	30	environments	environment	NOUN
admet-2334	279	31	)	)	PUNCT
admet-2334	279	32	of	of	ADP
admet-2334	279	33	bro5	bro5	NOUN
admet-2334	279	34	compounds	compound	NOUN
admet-2334	279	35	.	.	PUNCT
admet-2334	280	1	chameleonicity	chameleonicity	NOUN
admet-2334	280	2	can	can	AUX
admet-2334	280	3	also	also	ADV
admet-2334	280	4	be	be	AUX
admet-2334	280	5	predicted	predict	VERB
admet-2334	280	6	using	use	VERB
admet-2334	280	7	computational	computational	ADJ
admet-2334	280	8	tools	tool	NOUN
admet-2334	280	9	that	that	PRON
admet-2334	280	10	generate	generate	VERB
admet-2334	280	11	conformers	conformer	NOUN
admet-2334	280	12	in	in	ADP
admet-2334	280	13	diverse	diverse	ADJ
admet-2334	280	14	environments	environment	NOUN
admet-2334	280	15	.	.	PUNCT
admet-2334	281	1	combining	combine	VERB
admet-2334	281	2	these	these	DET
admet-2334	281	3	descriptors	descriptor	NOUN
admet-2334	281	4	is	be	AUX
admet-2334	281	5	anticipated	anticipate	VERB
admet-2334	281	6	to	to	PART
admet-2334	281	7	greatly	greatly	ADV
admet-2334	281	8	enhance	enhance	VERB
admet-2334	281	9	the	the	DET
admet-2334	281	10	efficiency	efficiency	NOUN
admet-2334	281	11	of	of	ADP
admet-2334	281	12	bro5	bro5	NOUN
admet-2334	281	13	drug	drug	NOUN
admet-2334	281	14	discovery	discovery	NOUN
admet-2334	281	15	campaigns	campaign	NOUN
admet-2334	281	16	by	by	ADP
admet-2334	281	17	offering	offer	VERB
admet-2334	281	18	robust	robust	ADJ
admet-2334	281	19	filtering	filtering	NOUN
admet-2334	281	20	and	and	CCONJ
admet-2334	281	21	prioritization	prioritization	NOUN
admet-2334	281	22	strategies	strategy	NOUN
admet-2334	281	23	.	.	PUNCT
admet-2334	282	1	however	however	ADV
admet-2334	282	2	,	,	PUNCT
admet-2334	282	3	some	some	DET
admet-2334	282	4	issues	issue	NOUN
admet-2334	282	5	remain	remain	VERB
admet-2334	282	6	to	to	PART
admet-2334	282	7	be	be	AUX
admet-2334	282	8	solved	solve	VERB
admet-2334	282	9	.	.	PUNCT
admet-2334	283	1	this	this	DET
admet-2334	283	2	paper	paper	NOUN
admet-2334	283	3	reports	report	VERB
admet-2334	283	4	the	the	DET
admet-2334	283	5	full	full	ADJ
admet-2334	283	6	physicochemical	physicochemical	ADJ
admet-2334	283	7	characterization	characterization	NOUN
admet-2334	283	8	of	of	ADP
admet-2334	283	9	three	three	NUM
admet-2334	283	10	protacs	protac	NOUN
admet-2334	283	11	in	in	ADP
admet-2334	283	12	clinical	clinical	ADJ
admet-2334	283	13	trials	trial	NOUN
admet-2334	283	14	.	.	PUNCT
admet-2334	284	1	the	the	DET
admet-2334	284	2	data	datum	NOUN
admet-2334	284	3	and	and	CCONJ
admet-2334	284	4	their	their	PRON
admet-2334	284	5	interpretation	interpretation	NOUN
admet-2334	284	6	are	be	AUX
admet-2334	284	7	robust	robust	ADJ
admet-2334	284	8	for	for	ADP
admet-2334	284	9	two	two	NUM
admet-2334	284	10	of	of	ADP
admet-2334	284	11	them	they	PRON
admet-2334	284	12	,	,	PUNCT
admet-2334	284	13	which	which	PRON
admet-2334	284	14	can	can	AUX
admet-2334	284	15	be	be	AUX
admet-2334	284	16	considered	consider	VERB
admet-2334	284	17	predominantly	predominantly	ADV
admet-2334	284	18	neutral	neutral	ADJ
admet-2334	284	19	at	at	ADP
admet-2334	284	20	ph	ph	PROPN
admet-2334	284	21	7	7	NUM
admet-2334	284	22	.	.	PUNCT
admet-2334	285	1	however	however	ADV
admet-2334	285	2	,	,	PUNCT
admet-2334	285	3	all	all	DET
admet-2334	285	4	the	the	DET
admet-2334	285	5	strategies	strategy	NOUN
admet-2334	285	6	encounter	encounter	VERB
admet-2334	285	7	significant	significant	ADJ
admet-2334	285	8	limitations	limitation	NOUN
admet-2334	285	9	with	with	ADP
admet-2334	285	10	the	the	DET
admet-2334	285	11	third	third	ADJ
admet-2334	285	12	protac	protac	NOUN
admet-2334	285	13	due	due	ADP
admet-2334	285	14	to	to	ADP
admet-2334	285	15	its	its	PRON
admet-2334	285	16	complex	complex	ADJ
admet-2334	285	17	ionization	ionization	NOUN
admet-2334	285	18	profile	profile	NOUN
admet-2334	285	19	.	.	PUNCT
admet-2334	286	1	research	research	NOUN
admet-2334	286	2	in	in	ADP
admet-2334	286	3	this	this	DET
admet-2334	286	4	area	area	NOUN
admet-2334	286	5	is	be	AUX
admet-2334	286	6	ongoing	ongoing	ADJ
admet-2334	286	7	in	in	ADP
admet-2334	286	8	our	our	PRON
admet-2334	286	9	laboratory	laboratory	NOUN
admet-2334	286	10	and	and	CCONJ
admet-2334	286	11	,	,	PUNCT
admet-2334	286	12	hopefully	hopefully	ADV
admet-2334	286	13	,	,	PUNCT
admet-2334	286	14	in	in	ADP
admet-2334	286	15	other	other	ADJ
admet-2334	286	16	labs	lab	NOUN
admet-2334	286	17	as	as	ADV
admet-2334	286	18	well	well	ADV
admet-2334	286	19	.	.	PUNCT
admet-2334	287	1	methods	method	NOUN
admet-2334	287	2	experimental	experimental	ADJ
admet-2334	287	3	physicochemical	physicochemical	ADJ
admet-2334	287	4	data	datum	NOUN
admet-2334	287	5	of	of	ADP
admet-2334	287	6	the	the	DET
admet-2334	287	7	three	three	NUM
admet-2334	287	8	protacs	protac	NOUN
admet-2334	287	9	were	be	AUX
admet-2334	287	10	obtained	obtain	VERB
admet-2334	287	11	as	as	SCONJ
admet-2334	287	12	reported	report	VERB
admet-2334	287	13	in	in	ADP
admet-2334	287	14	the	the	DET
admet-2334	287	15	original	original	ADJ
admet-2334	287	16	papers	paper	NOUN
admet-2334	287	17	[	[	X
admet-2334	287	18	23,40	23,40	NUM
admet-2334	287	19	]	]	X
admet-2334	287	20	.	.	PUNCT
admet-2334	288	1	admet	admet	PROPN
admet-2334	288	2	&	&	CCONJ
admet-2334	288	3	dmpk	dmpk	PROPN
admet-2334	288	4	12(5	12(5	NUM
admet-2334	288	5	)	)	PUNCT
admet-2334	288	6	(	(	PUNCT
admet-2334	288	7	2024	2024	NUM
admet-2334	288	8	)	)	PUNCT
admet-2334	288	9	721	721	NUM
admet-2334	288	10	-	-	NUM
admet-2334	288	11	736	736	NUM
admet-2334	288	12	designing	design	VERB
admet-2334	288	13	the	the	DET
admet-2334	288	14	next	next	ADJ
admet-2334	288	15	generation	generation	NOUN
admet-2334	288	16	of	of	ADP
admet-2334	288	17	oral	oral	ADJ
admet-2334	288	18	beyond	beyond	ADP
admet-2334	288	19	rule	rule	NOUN
admet-2334	288	20	of	of	ADP
admet-2334	288	21	five	five	NUM
admet-2334	288	22	drugs	drug	NOUN
admet-2334	288	23	doi	doi	NOUN
admet-2334	288	24	:	:	PUNCT
admet-2334	288	25	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	NOUN
admet-2334	288	26	733	733	NUM
admet-2334	288	27	the	the	DET
admet-2334	288	28	computational	computational	ADJ
admet-2334	288	29	study	study	NOUN
admet-2334	288	30	was	be	AUX
admet-2334	288	31	performed	perform	VERB
admet-2334	288	32	using	use	VERB
admet-2334	288	33	the	the	DET
admet-2334	288	34	following	follow	VERB
admet-2334	288	35	software	software	NOUN
admet-2334	288	36	.	.	PUNCT
admet-2334	289	1	alvadesc	alvadesc	PROPN
admet-2334	289	2	(	(	PUNCT
admet-2334	289	3	version	version	NOUN
admet-2334	289	4	2.0.16	2.0.16	NUM
admet-2334	289	5	,	,	PUNCT
admet-2334	289	6	www.alvascience.com/alvadesc/	www.alvascience.com/alvadesc/	PROPN
admet-2334	289	7	)	)	PUNCT
admet-2334	289	8	,	,	PUNCT
admet-2334	289	9	vega	vega	PROPN
admet-2334	289	10	zz	zz	PROPN
admet-2334	289	11	(	(	PUNCT
admet-2334	289	12	version	version	PROPN
admet-2334	289	13	3.2.3	3.2.3	NUM
admet-2334	289	14	,	,	PUNCT
admet-2334	289	15	https://www.ddl.unimi.it/	https://www.ddl.unimi.it/	PROPN
admet-2334	289	16	)	)	PUNCT
admet-2334	289	17	and	and	CCONJ
admet-2334	289	18	datawarrior	datawarrior	ADJ
admet-2334	289	19	(	(	PUNCT
admet-2334	289	20	version	version	PROPN
admet-2334	289	21	06.01.00	06.01.00	PROPN
admet-2334	289	22	,	,	PUNCT
admet-2334	289	23	https://openmolecules.org/datawarrior/	https://openmolecules.org/datawarrior/	PRON
admet-2334	289	24	)	)	PUNCT
admet-2334	289	25	were	be	AUX
admet-2334	289	26	used	use	VERB
admet-2334	289	27	to	to	PART
admet-2334	289	28	calculate	calculate	VERB
admet-2334	289	29	the	the	DET
admet-2334	289	30	3d	3d	PROPN
admet-2334	289	31	descriptors	descriptor	NOUN
admet-2334	289	32	.	.	PUNCT
admet-2334	290	1	the	the	DET
admet-2334	290	2	macromodel	macromodel	NOUN
admet-2334	290	3	plugin	plugin	NOUN
admet-2334	290	4	in	in	ADP
admet-2334	290	5	the	the	DET
admet-2334	290	6	maestro	maestro	ADJ
admet-2334	290	7	suite	suite	NOUN
admet-2334	290	8	(	(	PUNCT
admet-2334	290	9	schrödinger	schrödinger	ADJ
admet-2334	290	10	,	,	PUNCT
admet-2334	290	11	https://newsite.schrodinger.com/	https://newsite.schrodinger.com/	NOUN
admet-2334	290	12	)	)	PUNCT
admet-2334	290	13	and	and	CCONJ
admet-2334	290	14	vega	vega	PROPN
admet-2334	290	15	zz	zz	PROPN
admet-2334	290	16	were	be	AUX
admet-2334	290	17	employed	employ	VERB
admet-2334	290	18	for	for	ADP
admet-2334	290	19	the	the	DET
admet-2334	290	20	conformational	conformational	ADJ
admet-2334	290	21	analysis	analysis	NOUN
admet-2334	290	22	.	.	PUNCT
admet-2334	291	1	the	the	DET
admet-2334	291	2	macromodel	macromodel	PROPN
admet-2334	291	3	methodology	methodology	NOUN
admet-2334	291	4	is	be	AUX
admet-2334	291	5	reported	report	VERB
admet-2334	291	6	elsewhere	elsewhere	ADV
admet-2334	291	7	.	.	PUNCT
admet-2334	292	1	[	[	X
admet-2334	292	2	48	48	NUM
admet-2334	292	3	]	]	PUNCT
admet-2334	292	4	the	the	DET
admet-2334	292	5	vega	vega	PROPN
admet-2334	292	6	zz	zz	PROPN
admet-2334	292	7	methodology	methodology	NOUN
admet-2334	292	8	is	be	AUX
admet-2334	292	9	the	the	DET
admet-2334	292	10	following	following	NOUN
admet-2334	292	11	:	:	PUNCT
admet-2334	292	12	first	first	ADV
admet-2334	292	13	,	,	PUNCT
admet-2334	292	14	the	the	DET
admet-2334	292	15	smiles	smile	NOUN
admet-2334	292	16	codes	code	NOUN
admet-2334	292	17	of	of	ADP
admet-2334	292	18	the	the	DET
admet-2334	292	19	three	three	NUM
admet-2334	292	20	protacs	protac	NOUN
admet-2334	292	21	are	be	AUX
admet-2334	292	22	converted	convert	VERB
admet-2334	292	23	into	into	ADP
admet-2334	292	24	3d	3d	NUM
admet-2334	292	25	structures	structure	NOUN
admet-2334	292	26	with	with	ADP
admet-2334	292	27	corina	corina	PROPN
admet-2334	292	28	(	(	PUNCT
admet-2334	292	29	https://demos.mn-am.com/corina_interactive.html	https://demos.mn-am.com/corina_interactive.html	PROPN
admet-2334	292	30	)	)	PUNCT
admet-2334	292	31	and	and	CCONJ
admet-2334	292	32	then	then	ADV
admet-2334	292	33	submitted	submit	VERB
admet-2334	292	34	to	to	ADP
admet-2334	292	35	conformational	conformational	ADJ
admet-2334	292	36	sampling	sampling	NOUN
admet-2334	292	37	using	use	VERB
admet-2334	292	38	the	the	DET
admet-2334	292	39	implemented	implement	VERB
admet-2334	292	40	ammp	ammp	ADJ
admet-2334	292	41	program	program	NOUN
admet-2334	292	42	based	base	VERB
admet-2334	292	43	on	on	ADP
admet-2334	292	44	the	the	DET
admet-2334	292	45	sp4	sp4	NOUN
admet-2334	292	46	force	force	NOUN
admet-2334	292	47	field	field	NOUN
admet-2334	292	48	and	and	CCONJ
admet-2334	292	49	the	the	DET
admet-2334	292	50	boltzman	boltzman	NOUN
admet-2334	292	51	jump	jump	NOUN
admet-2334	292	52	algorithm	algorithm	NOUN
admet-2334	292	53	(	(	PUNCT
admet-2334	292	54	temperature	temperature	NOUN
admet-2334	292	55	=	=	SYM
admet-2334	292	56	10000	10000	NUM
admet-2334	292	57	,	,	PUNCT
admet-2334	292	58	number	number	NOUN
admet-2334	292	59	of	of	ADP
admet-2334	292	60	minimized	minimized	ADJ
admet-2334	292	61	conformations	conformation	NOUN
admet-2334	292	62	=	=	NOUN
admet-2334	292	63	1000	1000	NUM
admet-2334	292	64	)	)	PUNCT
admet-2334	292	65	.	.	PUNCT
admet-2334	293	1	conformers	conformer	NOUN
admet-2334	293	2	are	be	AUX
admet-2334	293	3	generated	generate	VERB
admet-2334	293	4	both	both	PRON
admet-2334	293	5	in	in	ADP
admet-2334	293	6	chloroform	chloroform	NOUN
admet-2334	293	7	and	and	CCONJ
admet-2334	293	8	in	in	ADP
admet-2334	293	9	water	water	NOUN
admet-2334	293	10	by	by	ADP
admet-2334	293	11	means	mean	NOUN
admet-2334	293	12	of	of	ADP
admet-2334	293	13	an	an	DET
admet-2334	293	14	implicit	implicit	ADJ
admet-2334	293	15	solvent	solvent	NOUN
admet-2334	293	16	model	model	NOUN
admet-2334	293	17	with	with	ADP
admet-2334	293	18	a	a	DET
admet-2334	293	19	dielectric	dielectric	ADJ
admet-2334	293	20	constant	constant	ADJ
admet-2334	293	21	value	value	NOUN
admet-2334	293	22	of	of	ADP
admet-2334	293	23	4.18	4.18	NUM
admet-2334	293	24	and	and	CCONJ
admet-2334	293	25	80	80	NUM
admet-2334	293	26	,	,	PUNCT
admet-2334	293	27	respectively	respectively	ADV
admet-2334	293	28	.	.	PUNCT
admet-2334	294	1	acknowledgements	acknowledgement	NOUN
admet-2334	294	2	:	:	PUNCT
admet-2334	294	3	the	the	DET
admet-2334	294	4	authors	author	NOUN
admet-2334	294	5	thank	thank	VERB
admet-2334	294	6	the	the	DET
admet-2334	294	7	crt	crt	PROPN
admet-2334	294	8	foundation	foundation	PROPN
admet-2334	294	9	(	(	PUNCT
admet-2334	294	10	program	program	NOUN
admet-2334	294	11	“	"	PUNCT
admet-2334	294	12	erogazioni	erogazioni	NOUN
admet-2334	294	13	ordinarie	ordinarie	PROPN
admet-2334	294	14	”	"	PUNCT
admet-2334	294	15	2019	2019	NUM
admet-2334	294	16	)	)	PUNCT
admet-2334	294	17	and	and	CCONJ
admet-2334	294	18	the	the	DET
admet-2334	294	19	italian	italian	ADJ
admet-2334	294	20	ministry	ministry	PROPN
admet-2334	294	21	of	of	ADP
admet-2334	294	22	university	university	PROPN
admet-2334	294	23	and	and	CCONJ
admet-2334	294	24	research	research	NOUN
admet-2334	294	25	(	(	PUNCT
admet-2334	294	26	mur	mur	PROPN
admet-2334	294	27	)	)	PUNCT
admet-2334	294	28	.	.	PUNCT
admet-2334	295	1	conflict	conflict	NOUN
admet-2334	295	2	of	of	ADP
admet-2334	295	3	interest	interest	NOUN
admet-2334	295	4	:	:	PUNCT
admet-2334	295	5	the	the	DET
admet-2334	295	6	authors	author	NOUN
admet-2334	295	7	declare	declare	VERB
admet-2334	295	8	no	no	DET
admet-2334	295	9	conflict	conflict	NOUN
admet-2334	295	10	of	of	ADP
admet-2334	295	11	interest	interest	NOUN
admet-2334	295	12	.	.	PUNCT
admet-2334	296	1	references	reference	NOUN
admet-2334	296	2	[	[	X
admet-2334	296	3	1	1	NUM
admet-2334	296	4	]	]	X
admet-2334	296	5	c.v	c.v	PROPN
admet-2334	296	6	.	.	PROPN
admet-2334	296	7	dang	dang	PROPN
admet-2334	296	8	,	,	PUNCT
admet-2334	296	9	e.p	e.p	PROPN
admet-2334	296	10	.	.	PROPN
admet-2334	296	11	reddy	reddy	PROPN
admet-2334	296	12	,	,	PUNCT
admet-2334	296	13	k.m	k.m	PROPN
admet-2334	296	14	.	.	PROPN
admet-2334	296	15	shokat	shokat	PROPN
admet-2334	296	16	,	,	PUNCT
admet-2334	296	17	l.	l.	PROPN
admet-2334	296	18	soucek	soucek	PROPN
admet-2334	296	19	.	.	PUNCT
admet-2334	297	1	drugging	drug	VERB
admet-2334	297	2	the	the	DET
admet-2334	297	3	‘	'	PUNCT
admet-2334	297	4	undruggable	undruggable	ADJ
admet-2334	297	5	’	'	PUNCT
admet-2334	297	6	cancer	cancer	NOUN
admet-2334	297	7	targets	target	NOUN
admet-2334	297	8	.	.	PUNCT
admet-2334	298	1	nature	nature	NOUN
admet-2334	298	2	reviews	review	VERB
admet-2334	298	3	cancer	cancer	NOUN
admet-2334	298	4	17	17	NUM
admet-2334	298	5	(	(	PUNCT
admet-2334	298	6	2017	2017	NUM
admet-2334	298	7	)	)	PUNCT
admet-2334	298	8	502	502	NUM
admet-2334	298	9	-	-	SYM
admet-2334	298	10	508	508	NUM
admet-2334	298	11	.	.	PUNCT
admet-2334	299	1	https://doi.org/10.1038/nrc.2017.36	https://doi.org/10.1038/nrc.2017.36	NOUN
admet-2334	299	2	.	.	PUNCT
admet-2334	300	1	[	[	X
admet-2334	300	2	2	2	NUM
admet-2334	300	3	]	]	X
admet-2334	300	4	m.j	m.j	PROPN
admet-2334	300	5	.	.	PROPN
admet-2334	300	6	blanco	blanco	PROPN
admet-2334	300	7	,	,	PUNCT
admet-2334	300	8	k.m	k.m	PROPN
admet-2334	300	9	.	.	PROPN
admet-2334	300	10	gardinier	gardinier	PROPN
admet-2334	300	11	.	.	PUNCT
admet-2334	301	1	new	new	ADJ
admet-2334	301	2	chemical	chemical	NOUN
admet-2334	301	3	modalities	modality	NOUN
admet-2334	301	4	and	and	CCONJ
admet-2334	301	5	strategic	strategic	ADJ
admet-2334	301	6	thinking	thinking	NOUN
admet-2334	301	7	in	in	ADP
admet-2334	301	8	early	early	ADJ
admet-2334	301	9	drug	drug	NOUN
admet-2334	301	10	discovery	discovery	NOUN
admet-2334	301	11	.	.	PUNCT
admet-2334	302	1	acs	acs	PROPN
admet-2334	302	2	medicinal	medicinal	ADJ
admet-2334	302	3	chemistry	chemistry	NOUN
admet-2334	302	4	letters	letter	NOUN
admet-2334	302	5	11	11	NUM
admet-2334	302	6	(	(	PUNCT
admet-2334	302	7	2020	2020	NUM
admet-2334	302	8	)	)	PUNCT
admet-2334	302	9	228	228	NUM
admet-2334	302	10	-	-	SYM
admet-2334	302	11	231	231	NUM
admet-2334	302	12	.	.	PUNCT
admet-2334	303	1	https://doi.org/10.1021/acsmedchemlett.9b00582	https://doi.org/10.1021/acsmedchemlett.9b00582	NOUN
admet-2334	303	2	.	.	PUNCT
admet-2334	304	1	[	[	X
admet-2334	304	2	3	3	NUM
admet-2334	304	3	]	]	X
admet-2334	304	4	m.j	m.j	PROPN
admet-2334	304	5	.	.	PROPN
admet-2334	304	6	blanco	blanco	PROPN
admet-2334	304	7	,	,	PUNCT
admet-2334	304	8	k.m	k.m	PROPN
admet-2334	304	9	.	.	PROPN
admet-2334	304	10	gardinier	gardinier	PROPN
admet-2334	304	11	,	,	PUNCT
admet-2334	304	12	m.n	m.n	PROPN
admet-2334	304	13	.	.	PROPN
admet-2334	304	14	namchuk	namchuk	PROPN
admet-2334	304	15	.	.	PUNCT
admet-2334	305	1	advancing	advance	VERB
admet-2334	305	2	new	new	ADJ
admet-2334	305	3	chemical	chemical	NOUN
admet-2334	305	4	modalities	modality	NOUN
admet-2334	305	5	into	into	ADP
admet-2334	305	6	clinical	clinical	ADJ
admet-2334	305	7	studies	study	NOUN
admet-2334	305	8	.	.	PUNCT
admet-2334	306	1	acs	acs	PROPN
admet-2334	306	2	medicinal	medicinal	ADJ
admet-2334	306	3	chemistry	chemistry	NOUN
admet-2334	306	4	letters	letter	NOUN
admet-2334	306	5	13	13	NUM
admet-2334	306	6	(	(	PUNCT
admet-2334	306	7	2022	2022	NUM
admet-2334	306	8	)	)	PUNCT
admet-2334	306	9	1691	1691	NUM
admet-2334	306	10	-	-	SYM
admet-2334	306	11	1698	1698	NUM
admet-2334	306	12	.	.	PUNCT
admet-2334	307	1	https://doi.org/10.1021/acsmedchemlett.2c00375	https://doi.org/10.1021/acsmedchemlett.2c00375	NOUN
admet-2334	307	2	.	.	PUNCT
admet-2334	308	1	[	[	X
admet-2334	308	2	4	4	NUM
admet-2334	308	3	]	]	X
admet-2334	308	4	a.c	a.c	PROPN
admet-2334	308	5	.	.	PROPN
admet-2334	308	6	lai	lai	PROPN
admet-2334	308	7	,	,	PUNCT
admet-2334	308	8	c.m	c.m	PROPN
admet-2334	308	9	.	.	PROPN
admet-2334	308	10	crews	crew	NOUN
admet-2334	308	11	.	.	PUNCT
admet-2334	309	1	induced	induce	VERB
admet-2334	309	2	protein	protein	NOUN
admet-2334	309	3	degradation	degradation	NOUN
admet-2334	309	4	:	:	PUNCT
admet-2334	309	5	an	an	DET
admet-2334	309	6	emerging	emerge	VERB
admet-2334	309	7	drug	drug	NOUN
admet-2334	309	8	discovery	discovery	NOUN
admet-2334	309	9	paradigm	paradigm	NOUN
admet-2334	309	10	.	.	PUNCT
admet-2334	310	1	nature	nature	NOUN
admet-2334	310	2	reviews	review	VERB
admet-2334	310	3	drug	drug	NOUN
admet-2334	310	4	discovery	discovery	NOUN
admet-2334	310	5	16	16	NUM
admet-2334	310	6	(	(	PUNCT
admet-2334	310	7	2017	2017	NUM
admet-2334	310	8	)	)	PUNCT
admet-2334	310	9	101	101	NUM
admet-2334	310	10	-	-	SYM
admet-2334	310	11	114	114	NUM
admet-2334	310	12	.	.	PUNCT
admet-2334	311	1	https://doi.org/10.1038/nrd.2016.211	https://doi.org/10.1038/nrd.2016.211	NOUN
admet-2334	311	2	.	.	PUNCT
admet-2334	312	1	[	[	X
admet-2334	312	2	5	5	X
admet-2334	312	3	]	]	PUNCT
admet-2334	312	4	d.	d.	PROPN
admet-2334	312	5	garcia	garcia	PROPN
admet-2334	312	6	jimenez	jimenez	PROPN
admet-2334	312	7	,	,	PUNCT
admet-2334	312	8	v.	v.	ADP
admet-2334	312	9	poongavanam	poongavanam	PROPN
admet-2334	312	10	,	,	PUNCT
admet-2334	312	11	j.	j.	PROPN
admet-2334	312	12	kihlberg	kihlberg	PROPN
admet-2334	312	13	.	.	PUNCT
admet-2334	313	1	macrocycles	macrocycle	NOUN
admet-2334	313	2	in	in	ADP
admet-2334	313	3	drug	drug	NOUN
admet-2334	313	4	discovery	discovery	NOUN
admet-2334	313	5	─	─	NOUN
admet-2334	313	6	learning	learn	VERB
admet-2334	313	7	from	from	ADP
admet-2334	313	8	the	the	DET
admet-2334	313	9	past	past	NOUN
admet-2334	313	10	for	for	ADP
admet-2334	313	11	the	the	DET
admet-2334	313	12	future	future	NOUN
admet-2334	313	13	.	.	PUNCT
admet-2334	314	1	journal	journal	NOUN
admet-2334	314	2	of	of	ADP
admet-2334	314	3	medicinal	medicinal	ADJ
admet-2334	314	4	chemistry	chemistry	NOUN
admet-2334	314	5	66	66	NUM
admet-2334	314	6	(	(	PUNCT
admet-2334	314	7	2023	2023	NUM
admet-2334	314	8	)	)	PUNCT
admet-2334	314	9	5377	5377	NUM
admet-2334	314	10	-	-	SYM
admet-2334	314	11	5396	5396	NUM
admet-2334	314	12	.	.	PUNCT
admet-2334	315	1	https://doi.org/10.1021/acs.jmedchem.3c00134	https://doi.org/10.1021/acs.jmedchem.3c00134	NOUN
admet-2334	315	2	.	.	PUNCT
admet-2334	316	1	[	[	X
admet-2334	316	2	6	6	NUM
admet-2334	316	3	]	]	X
admet-2334	316	4	d.s	d.s	PROPN
admet-2334	316	5	.	.	PROPN
admet-2334	316	6	nielsen	nielsen	PROPN
admet-2334	316	7	,	,	PUNCT
admet-2334	316	8	n.e	n.e	PROPN
admet-2334	316	9	.	.	PROPN
admet-2334	316	10	shepherd	shepherd	PROPN
admet-2334	316	11	,	,	PUNCT
admet-2334	316	12	w.	w.	PROPN
admet-2334	316	13	xu	xu	PROPN
admet-2334	316	14	,	,	PUNCT
admet-2334	316	15	a.j	a.j	PROPN
admet-2334	316	16	.	.	PROPN
admet-2334	316	17	lucke	lucke	PROPN
admet-2334	316	18	,	,	PUNCT
admet-2334	316	19	m.j	m.j	PROPN
admet-2334	316	20	.	.	PROPN
admet-2334	316	21	stoermer	stoermer	PROPN
admet-2334	316	22	,	,	PUNCT
admet-2334	316	23	d.p	d.p	PROPN
admet-2334	316	24	.	.	PROPN
admet-2334	316	25	fairlie	fairlie	PROPN
admet-2334	316	26	.	.	PROPN
admet-2334	316	27	orally	orally	ADV
admet-2334	316	28	absorbed	absorb	VERB
admet-2334	316	29	cyclic	cyclic	ADJ
admet-2334	316	30	peptides	peptide	NOUN
admet-2334	316	31	.	.	PUNCT
admet-2334	317	1	chemical	chemical	ADJ
admet-2334	317	2	reviews	review	NOUN
admet-2334	317	3	117	117	NUM
admet-2334	317	4	(	(	PUNCT
admet-2334	317	5	2017	2017	NUM
admet-2334	317	6	)	)	PUNCT
admet-2334	317	7	8094	8094	NUM
admet-2334	317	8	-	-	SYM
admet-2334	317	9	8128	8128	NUM
admet-2334	317	10	.	.	PUNCT
admet-2334	318	1	https://doi.org/10.1021/acs.chemrev.6b00838	https://doi.org/10.1021/acs.chemrev.6b00838	X
admet-2334	318	2	.	.	PUNCT
admet-2334	319	1	[	[	X
admet-2334	319	2	7	7	X
admet-2334	319	3	]	]	PUNCT
admet-2334	319	4	a.	a.	NOUN
admet-2334	319	5	seelig	seelig	PROPN
admet-2334	319	6	.	.	PUNCT
admet-2334	320	1	p	p	X
admet-2334	320	2	-	-	PUNCT
admet-2334	320	3	glycoprotein	glycoprotein	NOUN
admet-2334	320	4	:	:	PUNCT
admet-2334	320	5	one	one	NUM
admet-2334	320	6	mechanism	mechanism	NOUN
admet-2334	320	7	,	,	PUNCT
admet-2334	320	8	many	many	ADJ
admet-2334	320	9	tasks	task	NOUN
admet-2334	320	10	and	and	CCONJ
admet-2334	320	11	the	the	DET
admet-2334	320	12	consequences	consequence	NOUN
admet-2334	320	13	for	for	ADP
admet-2334	320	14	pharmacotherapy	pharmacotherapy	NOUN
admet-2334	320	15	of	of	ADP
admet-2334	320	16	cancers	cancer	NOUN
admet-2334	320	17	.	.	PUNCT
admet-2334	321	1	frontiers	frontier	NOUN
admet-2334	321	2	in	in	ADP
admet-2334	321	3	oncology	oncology	NOUN
admet-2334	321	4	10	10	NUM
admet-2334	321	5	(	(	PUNCT
admet-2334	321	6	2020	2020	NUM
admet-2334	321	7	)	)	PUNCT
admet-2334	321	8	.	.	PUNCT
admet-2334	322	1	https://doi.org/10.3389/fonc.2020.576559	https://doi.org/10.3389/fonc.2020.576559	PROPN
admet-2334	322	2	.	.	PUNCT
admet-2334	323	1	[	[	X
admet-2334	323	2	8	8	NUM
admet-2334	323	3	]	]	X
admet-2334	323	4	m.t	m.t	PROPN
admet-2334	323	5	.	.	PROPN
admet-2334	323	6	kim	kim	PROPN
admet-2334	323	7	,	,	PUNCT
admet-2334	323	8	a.	a.	NOUN
admet-2334	323	9	sedykh	sedykh	PROPN
admet-2334	323	10	,	,	PUNCT
admet-2334	323	11	s.k	s.k	PROPN
admet-2334	323	12	.	.	PROPN
admet-2334	323	13	chakravarti	chakravarti	PROPN
admet-2334	323	14	,	,	PUNCT
admet-2334	323	15	r.d	r.d	PROPN
admet-2334	323	16	.	.	PROPN
admet-2334	323	17	saiakhov	saiakhov	PROPN
admet-2334	323	18	,	,	PUNCT
admet-2334	323	19	h.	h.	PROPN
admet-2334	323	20	zhu	zhu	PROPN
admet-2334	323	21	.	.	PUNCT
admet-2334	324	1	critical	critical	ADJ
admet-2334	324	2	evaluation	evaluation	NOUN
admet-2334	324	3	of	of	ADP
admet-2334	324	4	human	human	ADJ
admet-2334	324	5	oral	oral	ADJ
admet-2334	324	6	bioavailability	bioavailability	NOUN
admet-2334	324	7	for	for	ADP
admet-2334	324	8	pharmaceutical	pharmaceutical	ADJ
admet-2334	324	9	drugs	drug	NOUN
admet-2334	324	10	by	by	ADP
admet-2334	324	11	using	use	VERB
admet-2334	324	12	various	various	ADJ
admet-2334	324	13	cheminformatics	cheminformatic	NOUN
admet-2334	324	14	approaches	approach	NOUN
admet-2334	324	15	.	.	PUNCT
admet-2334	325	1	pharmaceutical	pharmaceutical	ADJ
admet-2334	325	2	research	research	NOUN
admet-2334	325	3	31	31	NUM
admet-2334	325	4	(	(	PUNCT
admet-2334	325	5	2014	2014	NUM
admet-2334	325	6	)	)	PUNCT
admet-2334	325	7	1002	1002	NUM
admet-2334	325	8	-	-	SYM
admet-2334	325	9	1014	1014	NUM
admet-2334	325	10	.	.	PUNCT
admet-2334	326	1	https://doi.org/10.1007/s11095-013-1222-1	https://doi.org/10.1007/s11095-013-1222-1	X
admet-2334	326	2	.	.	PUNCT
admet-2334	327	1	[	[	X
admet-2334	327	2	9	9	NUM
admet-2334	327	3	]	]	X
admet-2334	327	4	g.	g.	PROPN
admet-2334	327	5	caron	caron	PROPN
admet-2334	327	6	,	,	PUNCT
admet-2334	327	7	v.	v.	ADP
admet-2334	327	8	digiesi	digiesi	PROPN
admet-2334	327	9	,	,	PUNCT
admet-2334	327	10	s.	s.	PROPN
admet-2334	327	11	solaro	solaro	NOUN
admet-2334	327	12	,	,	PUNCT
admet-2334	327	13	g.	g.	PROPN
admet-2334	327	14	ermondi	ermondi	PROPN
admet-2334	327	15	.	.	PUNCT
admet-2334	328	1	flexibility	flexibility	NOUN
admet-2334	328	2	in	in	ADP
admet-2334	328	3	early	early	ADJ
admet-2334	328	4	drug	drug	NOUN
admet-2334	328	5	discovery	discovery	NOUN
admet-2334	328	6	:	:	PUNCT
admet-2334	328	7	focus	focus	VERB
admet-2334	328	8	on	on	ADP
admet-2334	328	9	the	the	DET
admet-2334	328	10	beyondrule	beyondrule	NOUN
admet-2334	328	11	-	-	PUNCT
admet-2334	328	12	of-5	of-5	NOUN
admet-2334	328	13	chemical	chemical	NOUN
admet-2334	328	14	space	space	NOUN
admet-2334	328	15	.	.	PUNCT
admet-2334	329	1	drug	drug	NOUN
admet-2334	329	2	discovery	discovery	PROPN
admet-2334	329	3	today	today	NOUN
admet-2334	329	4	25	25	NUM
admet-2334	329	5	(	(	PUNCT
admet-2334	329	6	2020	2020	NUM
admet-2334	329	7	)	)	PUNCT
admet-2334	329	8	621	621	NUM
admet-2334	329	9	-	-	SYM
admet-2334	329	10	627	627	NUM
admet-2334	329	11	.	.	PUNCT
admet-2334	330	1	https://doi.org/10.1016/j.drudis.2020.01.012	https://doi.org/10.1016/j.drudis.2020.01.012	PROPN
admet-2334	330	2	.	.	PUNCT
admet-2334	331	1	[	[	X
admet-2334	331	2	10	10	NUM
admet-2334	331	3	]	]	X
admet-2334	331	4	e.	e.	PROPN
admet-2334	331	5	price	price	PROPN
admet-2334	331	6	,	,	PUNCT
admet-2334	331	7	m.	m.	NOUN
admet-2334	331	8	weinheimer	weinheimer	PROPN
admet-2334	331	9	,	,	PUNCT
admet-2334	331	10	a.	a.	NOUN
admet-2334	331	11	rivkin	rivkin	PROPN
admet-2334	331	12	,	,	PUNCT
admet-2334	331	13	g.	g.	PROPN
admet-2334	331	14	jenkins	jenkins	PROPN
admet-2334	331	15	,	,	PUNCT
admet-2334	331	16	m.	m.	NOUN
admet-2334	331	17	nijsen	nijsen	PROPN
admet-2334	331	18	,	,	PUNCT
admet-2334	331	19	p.b	p.b	PROPN
admet-2334	331	20	.	.	PROPN
admet-2334	331	21	cox	cox	PROPN
admet-2334	331	22	,	,	PUNCT
admet-2334	331	23	d.	d.	PROPN
admet-2334	331	24	degoey	degoey	PROPN
admet-2334	331	25	.	.	PUNCT
admet-2334	332	1	beyond	beyond	ADP
admet-2334	332	2	rule	rule	NOUN
admet-2334	332	3	of	of	ADP
admet-2334	332	4	five	five	NUM
admet-2334	332	5	and	and	CCONJ
admet-2334	332	6	protacs	protac	NOUN
admet-2334	332	7	in	in	ADP
admet-2334	332	8	modern	modern	ADJ
admet-2334	332	9	drug	drug	NOUN
admet-2334	332	10	discovery	discovery	NOUN
admet-2334	332	11	:	:	PUNCT
admet-2334	332	12	polarity	polarity	NOUN
admet-2334	332	13	reducers	reducer	NOUN
admet-2334	332	14	,	,	PUNCT
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admet-2334	332	16	,	,	PUNCT
admet-2334	332	17	and	and	CCONJ
admet-2334	332	18	the	the	DET
admet-2334	332	19	evolving	evolve	VERB
admet-2334	332	20	physicochemical	physicochemical	ADJ
admet-2334	332	21	landscape	landscape	NOUN
admet-2334	332	22	.	.	PUNCT
admet-2334	333	1	journal	journal	NOUN
admet-2334	333	2	of	of	ADP
admet-2334	333	3	medicinal	medicinal	ADJ
admet-2334	333	4	chemistry	chemistry	NOUN
admet-2334	333	5	67	67	NUM
admet-2334	333	6	(	(	PUNCT
admet-2334	333	7	2024	2024	NUM
admet-2334	333	8	)	)	PUNCT
admet-2334	333	9	5683	5683	NUM
admet-2334	333	10	-	-	SYM
admet-2334	333	11	5698	5698	NUM
admet-2334	333	12	.	.	PUNCT
admet-2334	334	1	https://doi.org/10.1021/acs.jmedchem.3c02332	https://doi.org/10.1021/acs.jmedchem.3c02332	X
admet-2334	334	2	.	.	PUNCT
admet-2334	335	1	[	[	X
admet-2334	335	2	11	11	NUM
admet-2334	335	3	]	]	PUNCT
admet-2334	335	4	a.	a.	NOUN
admet-2334	335	5	pike	pike	NOUN
admet-2334	335	6	,	,	PUNCT
admet-2334	335	7	b.	b.	PROPN
admet-2334	335	8	williamson	williamson	PROPN
admet-2334	335	9	,	,	PUNCT
admet-2334	335	10	s.	s.	PROPN
admet-2334	335	11	harlfinger	harlfinger	PROPN
admet-2334	335	12	,	,	PUNCT
admet-2334	335	13	s.	s.	PROPN
admet-2334	335	14	martin	martin	PROPN
admet-2334	335	15	,	,	PUNCT
admet-2334	335	16	d.f	d.f	PROPN
admet-2334	335	17	.	.	PROPN
admet-2334	335	18	mcginnity	mcginnity	NOUN
admet-2334	335	19	.	.	PUNCT
admet-2334	336	1	optimising	optimise	VERB
admet-2334	336	2	proteolysis	proteolysis	NOUN
admet-2334	336	3	-	-	PUNCT
admet-2334	336	4	targeting	target	VERB
admet-2334	336	5	chimeras	chimera	NOUN
admet-2334	336	6	(	(	PUNCT
admet-2334	336	7	protacs	protac	NOUN
admet-2334	336	8	)	)	PUNCT
admet-2334	336	9	for	for	ADP
admet-2334	336	10	oral	oral	ADJ
admet-2334	336	11	drug	drug	NOUN
admet-2334	336	12	delivery	delivery	NOUN
admet-2334	336	13	:	:	PUNCT
admet-2334	336	14	a	a	DET
admet-2334	336	15	drug	drug	NOUN
admet-2334	336	16	metabolism	metabolism	NOUN
admet-2334	336	17	and	and	CCONJ
admet-2334	336	18	pharmacokinetics	pharmacokinetic	NOUN
admet-2334	336	19	perspective	perspective	NOUN
admet-2334	336	20	.	.	PUNCT
admet-2334	337	1	drug	drug	NOUN
admet-2334	337	2	discovery	discovery	PROPN
admet-2334	337	3	today	today	NOUN
admet-2334	337	4	25	25	NUM
admet-2334	337	5	(	(	PUNCT
admet-2334	337	6	2020	2020	NUM
admet-2334	337	7	)	)	PUNCT
admet-2334	337	8	1793	1793	NUM
admet-2334	337	9	-	-	SYM
admet-2334	337	10	1800	1800	NUM
admet-2334	337	11	.	.	PUNCT
admet-2334	338	1	https://doi.org/10.1016/j.drudis.2020.07.013	https://doi.org/10.1016/j.drudis.2020.07.013	PROPN
admet-2334	338	2	.	.	PUNCT
admet-2334	339	1	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	340	1	http://www.alvascience.com/alvadesc/	http://www.alvascience.com/alvadesc/	X
admet-2334	340	2	https://www.ddl.unimi.it/	https://www.ddl.unimi.it/	PROPN
admet-2334	340	3	https://openmolecules.org/datawarrior/	https://openmolecules.org/datawarrior/	PROPN
admet-2334	340	4	https://newsite.schrodinger.com/	https://newsite.schrodinger.com/	PROPN
admet-2334	340	5	https://demos.mn-am.com/corina_interactive.html	https://demos.mn-am.com/corina_interactive.html	PROPN
admet-2334	340	6	https://doi.org/10.1038/nrc.2017.36	https://doi.org/10.1038/nrc.2017.36	PROPN
admet-2334	340	7	https://doi.org/10.1021/acsmedchemlett.9b00582	https://doi.org/10.1021/acsmedchemlett.9b00582	PROPN
admet-2334	340	8	https://doi.org/10.1021/acsmedchemlett.2c00375	https://doi.org/10.1021/acsmedchemlett.2c00375	ADJ
admet-2334	340	9	https://doi.org/10.1038/nrd.2016.211	https://doi.org/10.1038/nrd.2016.211	NOUN
admet-2334	340	10	https://doi.org/10.1021/acs.jmedchem.3c00134	https://doi.org/10.1021/acs.jmedchem.3c00134	VERB
admet-2334	340	11	https://doi.org/10.1021/acs.chemrev.6b00838	https://doi.org/10.1021/acs.chemrev.6b00838	PRON
admet-2334	341	1	https://doi.org/10.3389/fonc.2020.576559	https://doi.org/10.3389/fonc.2020.576559	PROPN
admet-2334	341	2	https://doi.org/10.1007/s11095-013-1222-1	https://doi.org/10.1007/s11095-013-1222-1	X
admet-2334	341	3	https://doi.org/10.1016/j.drudis.2020.01.012	https://doi.org/10.1016/j.drudis.2020.01.012	NOUN
admet-2334	341	4	https://doi.org/10.1021/acs.jmedchem.3c02332	https://doi.org/10.1021/acs.jmedchem.3c02332	PRON
admet-2334	341	5	https://doi.org/10.1016/j.drudis.2020.07.013	https://doi.org/10.1016/j.drudis.2020.07.013	NOUN
admet-2334	342	1	d.	d.	PROPN
admet-2334	342	2	g.	g.	PROPN
admet-2334	343	1	jiménez	jiménez	PROPN
admet-2334	343	2	et	et	PROPN
admet-2334	343	3	al	al	PROPN
admet-2334	343	4	.	.	PROPN
admet-2334	343	5	admet	admet	PROPN
admet-2334	343	6	&	&	CCONJ
admet-2334	343	7	dmpk	dmpk	PROPN
admet-2334	343	8	12(5	12(5	NUM
admet-2334	343	9	)	)	PUNCT
admet-2334	343	10	(	(	PUNCT
admet-2334	343	11	2024	2024	NUM
admet-2334	343	12	)	)	PUNCT
admet-2334	343	13	721	721	NUM
admet-2334	343	14	-	-	NUM
admet-2334	343	15	736	736	NUM
admet-2334	343	16	734	734	NUM
admet-2334	343	17	[	[	X
admet-2334	343	18	12	12	NUM
admet-2334	343	19	]	]	X
admet-2334	343	20	p.a	p.a	PROPN
admet-2334	343	21	.	.	PROPN
admet-2334	343	22	carrupt	carrupt	PROPN
admet-2334	343	23	,	,	PUNCT
admet-2334	343	24	b.	b.	PROPN
admet-2334	343	25	testa	testa	PROPN
admet-2334	343	26	,	,	PUNCT
admet-2334	343	27	a.	a.	NOUN
admet-2334	343	28	bechalany	bechalany	PROPN
admet-2334	343	29	,	,	PUNCT
admet-2334	343	30	n.	n.	PROPN
admet-2334	343	31	el	el	PROPN
admet-2334	343	32	tayar	tayar	PROPN
admet-2334	343	33	,	,	PUNCT
admet-2334	343	34	p.	p.	PROPN
admet-2334	343	35	descas	descas	PROPN
admet-2334	343	36	,	,	PUNCT
admet-2334	343	37	d.	d.	PROPN
admet-2334	343	38	perrissoud	perrissoud	PROPN
admet-2334	343	39	.	.	PUNCT
admet-2334	344	1	morphine	morphine	PROPN
admet-2334	344	2	6	6	NUM
admet-2334	344	3	-	-	PUNCT
admet-2334	344	4	glucuronide	glucuronide	NOUN
admet-2334	344	5	and	and	CCONJ
admet-2334	344	6	morphine	morphine	NOUN
admet-2334	344	7	3	3	NUM
admet-2334	344	8	-	-	PUNCT
admet-2334	344	9	glucuronide	glucuronide	NOUN
admet-2334	344	10	as	as	ADP
admet-2334	344	11	molecular	molecular	ADJ
admet-2334	344	12	chameleons	chameleon	NOUN
admet-2334	344	13	with	with	ADP
admet-2334	344	14	unexpected	unexpected	ADJ
admet-2334	344	15	lipophilicity	lipophilicity	NOUN
admet-2334	344	16	.	.	PUNCT
admet-2334	345	1	journal	journal	NOUN
admet-2334	345	2	of	of	ADP
admet-2334	345	3	medicinal	medicinal	ADJ
admet-2334	345	4	chemistry	chemistry	NOUN
admet-2334	345	5	34	34	NUM
admet-2334	345	6	(	(	PUNCT
admet-2334	345	7	1991	1991	NUM
admet-2334	345	8	)	)	PUNCT
admet-2334	345	9	1272	1272	NUM
admet-2334	345	10	-	-	SYM
admet-2334	345	11	1275	1275	NUM
admet-2334	345	12	.	.	PUNCT
admet-2334	346	1	[	[	X
admet-2334	346	2	13	13	NUM
admet-2334	346	3	]	]	PUNCT
admet-2334	346	4	a.	a.	PROPN
admet-2334	346	5	alex	alex	PROPN
admet-2334	346	6	,	,	PUNCT
admet-2334	346	7	d.s	d.s	PROPN
admet-2334	346	8	.	.	PROPN
admet-2334	346	9	millan	millan	PROPN
admet-2334	346	10	,	,	PUNCT
admet-2334	346	11	m.	m.	NOUN
admet-2334	346	12	perez	perez	PROPN
admet-2334	346	13	,	,	PUNCT
admet-2334	346	14	f.	f.	PROPN
admet-2334	346	15	wakenhut	wakenhut	PROPN
admet-2334	346	16	,	,	PUNCT
admet-2334	346	17	g.a	g.a	PROPN
admet-2334	346	18	.	.	PROPN
admet-2334	346	19	whitlock	whitlock	PROPN
admet-2334	346	20	.	.	PUNCT
admet-2334	347	1	intramolecular	intramolecular	ADJ
admet-2334	347	2	hydrogen	hydrogen	NOUN
admet-2334	347	3	bonding	bonding	NOUN
admet-2334	347	4	to	to	PART
admet-2334	347	5	improve	improve	VERB
admet-2334	347	6	membrane	membrane	NOUN
admet-2334	347	7	permeability	permeability	NOUN
admet-2334	347	8	and	and	CCONJ
admet-2334	347	9	absorption	absorption	NOUN
admet-2334	347	10	in	in	ADP
admet-2334	347	11	beyond	beyond	ADP
admet-2334	347	12	rule	rule	NOUN
admet-2334	347	13	of	of	ADP
admet-2334	347	14	five	five	NUM
admet-2334	347	15	chemical	chemical	ADJ
admet-2334	347	16	space	space	NOUN
admet-2334	347	17	.	.	PUNCT
admet-2334	348	1	medicinal	medicinal	ADJ
admet-2334	348	2	chemistry	chemistry	NOUN
admet-2334	348	3	communications	communication	NOUN
admet-2334	348	4	2	2	NUM
admet-2334	348	5	(	(	PUNCT
admet-2334	348	6	2011	2011	NUM
admet-2334	348	7	)	)	PUNCT
admet-2334	348	8	669	669	NUM
admet-2334	348	9	.	.	PUNCT
admet-2334	349	1	https://doi.org/10.1039/c1md00093d	https://doi.org/10.1039/c1md00093d	AUX
admet-2334	349	2	.	.	PUNCT
admet-2334	350	1	[	[	X
admet-2334	350	2	14	14	NUM
admet-2334	350	3	]	]	PUNCT
admet-2334	350	4	m.	m.	NOUN
admet-2334	350	5	vallaro	vallaro	NOUN
admet-2334	350	6	,	,	PUNCT
admet-2334	350	7	g.	g.	PROPN
admet-2334	350	8	ermondi	ermondi	PROPN
admet-2334	350	9	,	,	PUNCT
admet-2334	350	10	j.	j.	PROPN
admet-2334	350	11	saame	saame	PROPN
admet-2334	350	12	,	,	PUNCT
admet-2334	350	13	i.	i.	NOUN
admet-2334	350	14	leito	leito	PROPN
admet-2334	350	15	,	,	PUNCT
admet-2334	350	16	g.	g.	PROPN
admet-2334	350	17	caron	caron	PROPN
admet-2334	350	18	.	.	PUNCT
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admet-2334	350	20	and	and	CCONJ
admet-2334	350	21	lipophilicity	lipophilicity	NOUN
admet-2334	350	22	in	in	ADP
admet-2334	350	23	nonpolar	nonpolar	ADJ
admet-2334	350	24	media	medium	NOUN
admet-2334	350	25	mimicking	mimic	VERB
admet-2334	350	26	the	the	DET
admet-2334	350	27	cell	cell	NOUN
admet-2334	350	28	membrane	membrane	NOUN
admet-2334	350	29	interior	interior	NOUN
admet-2334	350	30	.	.	PUNCT
admet-2334	351	1	bioorganic	bioorganic	PROPN
admet-2334	351	2	&	&	CCONJ
admet-2334	351	3	medicinal	medicinal	ADJ
admet-2334	351	4	chemistry	chemistry	NOUN
admet-2334	351	5	81	81	NUM
admet-2334	351	6	(	(	PUNCT
admet-2334	351	7	2023	2023	NUM
admet-2334	351	8	)	)	PUNCT
admet-2334	351	9	117203	117203	NUM
admet-2334	351	10	.	.	PUNCT
admet-2334	352	1	https://doi.org/10.1016/j.bmc.2023.117203	https://doi.org/10.1016/j.bmc.2023.117203	X
admet-2334	352	2	.	.	PUNCT
admet-2334	353	1	[	[	X
admet-2334	353	2	15	15	NUM
admet-2334	353	3	]	]	X
admet-2334	353	4	g.	g.	PROPN
admet-2334	353	5	caron	caron	PROPN
admet-2334	353	6	,	,	PUNCT
admet-2334	353	7	m.	m.	NOUN
admet-2334	353	8	vallaro	vallaro	NOUN
admet-2334	353	9	,	,	PUNCT
admet-2334	353	10	g.	g.	PROPN
admet-2334	353	11	ermondi	ermondi	PROPN
admet-2334	353	12	,	,	PUNCT
admet-2334	353	13	g.h.g.h	g.h.g.h	PROPN
admet-2334	353	14	.	.	PUNCT
admet-2334	353	15	goetz	goetz	PROPN
admet-2334	353	16	,	,	PUNCT
admet-2334	353	17	y.a.y.a	y.a.y.a	PROPN
admet-2334	353	18	.	.	PROPN
admet-2334	353	19	abramov	abramov	PROPN
admet-2334	353	20	,	,	PUNCT
admet-2334	353	21	l.	l.	PROPN
admet-2334	353	22	philippe	philippe	PROPN
admet-2334	353	23	,	,	PUNCT
admet-2334	353	24	m.	m.	NOUN
admet-2334	353	25	shalaeva	shalaeva	PROPN
admet-2334	353	26	.	.	PUNCT
admet-2334	354	1	a	a	DET
admet-2334	354	2	fast	fast	ADJ
admet-2334	354	3	chromatographic	chromatographic	ADJ
admet-2334	354	4	method	method	NOUN
admet-2334	354	5	for	for	ADP
admet-2334	354	6	estimating	estimate	VERB
admet-2334	354	7	lipophilicity	lipophilicity	NOUN
admet-2334	354	8	and	and	CCONJ
admet-2334	354	9	ionization	ionization	NOUN
admet-2334	354	10	in	in	ADP
admet-2334	354	11	nonpolar	nonpolar	ADJ
admet-2334	354	12	membrane	membrane	NOUN
admet-2334	354	13	-	-	PUNCT
admet-2334	354	14	like	like	ADJ
admet-2334	354	15	environment	environment	NOUN
admet-2334	354	16	.	.	PUNCT
admet-2334	355	1	molecular	molecular	ADJ
admet-2334	355	2	pharmaceutics	pharmaceutic	NOUN
admet-2334	355	3	13	13	NUM
admet-2334	355	4	(	(	PUNCT
admet-2334	355	5	2016	2016	NUM
admet-2334	355	6	)	)	PUNCT
admet-2334	355	7	1100	1100	NUM
admet-2334	355	8	-	-	SYM
admet-2334	355	9	1110	1110	NUM
admet-2334	355	10	https://doi.org/10.1021/acs.molpharmaceut.5b00910	https://doi.org/10.1021/acs.molpharmaceut.5b00910	NOUN
admet-2334	355	11	.	.	PUNCT
admet-2334	356	1	[	[	X
admet-2334	356	2	16	16	NUM
admet-2334	356	3	]	]	PUNCT
admet-2334	356	4	p.	p.	PROPN
admet-2334	356	5	matsson	matsson	PROPN
admet-2334	356	6	,	,	PUNCT
admet-2334	356	7	j.	j.	PROPN
admet-2334	356	8	kihlberg	kihlberg	PROPN
admet-2334	356	9	.	.	PUNCT
admet-2334	357	1	how	how	SCONJ
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admet-2334	357	4	too	too	ADV
admet-2334	357	5	big	big	ADJ
admet-2334	357	6	for	for	ADP
admet-2334	357	7	cell	cell	NOUN
admet-2334	357	8	permeability	permeability	NOUN
admet-2334	357	9	?	?	PUNCT
admet-2334	357	10	.	.	PUNCT
admet-2334	358	1	journal	journal	PROPN
admet-2334	358	2	of	of	ADP
admet-2334	358	3	medicinal	medicinal	ADJ
admet-2334	358	4	chemistry	chemistry	NOUN
admet-2334	358	5	60	60	NUM
admet-2334	358	6	(	(	PUNCT
admet-2334	358	7	2017	2017	NUM
admet-2334	358	8	)	)	PUNCT
admet-2334	358	9	1662	1662	NUM
admet-2334	358	10	-	-	SYM
admet-2334	358	11	1664	1664	NUM
admet-2334	358	12	.	.	PUNCT
admet-2334	359	1	https://doi.org/10.1021/acs.jmedchem.7b00237	https://doi.org/10.1021/acs.jmedchem.7b00237	INTJ
admet-2334	359	2	.	.	PUNCT
admet-2334	360	1	[	[	X
admet-2334	360	2	17	17	NUM
admet-2334	360	3	]	]	X
admet-2334	360	4	c.r.w	c.r.w	PROPN
admet-2334	360	5	.	.	PUNCT
admet-2334	360	6	guimarães	guimarães	PROPN
admet-2334	360	7	,	,	PUNCT
admet-2334	360	8	a.m.	a.m.	PROPN
admet-2334	360	9	mathiowetz	mathiowetz	PROPN
admet-2334	360	10	,	,	PUNCT
admet-2334	360	11	m.	m.	NOUN
admet-2334	360	12	shalaeva	shalaeva	PROPN
admet-2334	360	13	,	,	PUNCT
admet-2334	360	14	g.	g.	PROPN
admet-2334	360	15	goetz	goetz	PROPN
admet-2334	360	16	,	,	PUNCT
admet-2334	360	17	s.	s.	PROPN
admet-2334	360	18	liras	liras	PROPN
admet-2334	360	19	.	.	PUNCT
admet-2334	361	1	use	use	NOUN
admet-2334	361	2	of	of	ADP
admet-2334	361	3	3d	3d	NUM
admet-2334	361	4	properties	property	NOUN
admet-2334	361	5	to	to	PART
admet-2334	361	6	characterize	characterize	VERB
admet-2334	361	7	beyond	beyond	ADP
admet-2334	361	8	rule	rule	NOUN
admet-2334	361	9	-	-	PUNCT
admet-2334	361	10	of-5	of-5	NOUN
admet-2334	361	11	property	property	NOUN
admet-2334	361	12	space	space	NOUN
admet-2334	361	13	for	for	ADP
admet-2334	361	14	passive	passive	ADJ
admet-2334	361	15	permeation	permeation	NOUN
admet-2334	361	16	.	.	PUNCT
admet-2334	362	1	journal	journal	PROPN
admet-2334	362	2	of	of	ADP
admet-2334	362	3	chemical	chemical	ADJ
admet-2334	362	4	information	information	NOUN
admet-2334	362	5	and	and	CCONJ
admet-2334	362	6	modeling	model	VERB
admet-2334	362	7	52	52	NUM
admet-2334	362	8	(	(	PUNCT
admet-2334	362	9	2012	2012	NUM
admet-2334	362	10	)	)	PUNCT
admet-2334	362	11	882	882	NUM
admet-2334	362	12	-	-	SYM
admet-2334	362	13	890	890	NUM
admet-2334	362	14	.	.	PUNCT
admet-2334	363	1	https://doi.org/10.1021/ci300010y	https://doi.org/10.1021/ci300010y	PROPN
admet-2334	363	2	.	.	PUNCT
admet-2334	364	1	[	[	X
admet-2334	364	2	18	18	NUM
admet-2334	364	3	]	]	PUNCT
admet-2334	364	4	m.	m.	NOUN
admet-2334	364	5	rossi	rossi	PROPN
admet-2334	364	6	sebastiano	sebastiano	PROPN
admet-2334	364	7	,	,	PUNCT
admet-2334	364	8	d.	d.	PROPN
admet-2334	364	9	garcia	garcia	PROPN
admet-2334	364	10	jimenez	jimenez	PROPN
admet-2334	364	11	,	,	PUNCT
admet-2334	364	12	m.	m.	NOUN
admet-2334	364	13	vallaro	vallaro	NOUN
admet-2334	364	14	,	,	PUNCT
admet-2334	364	15	g.	g.	PROPN
admet-2334	364	16	caron	caron	PROPN
admet-2334	364	17	,	,	PUNCT
admet-2334	364	18	g.	g.	PROPN
admet-2334	364	19	ermondi	ermondi	PROPN
admet-2334	364	20	.	.	PUNCT
admet-2334	365	1	refinement	refinement	NOUN
admet-2334	365	2	of	of	ADP
admet-2334	365	3	computational	computational	ADJ
admet-2334	365	4	access	access	NOUN
admet-2334	365	5	to	to	ADP
admet-2334	365	6	molecular	molecular	ADJ
admet-2334	365	7	physicochemical	physicochemical	ADJ
admet-2334	365	8	properties	property	NOUN
admet-2334	365	9	:	:	PUNCT
admet-2334	365	10	from	from	ADP
admet-2334	365	11	ro5	ro5	ADJ
admet-2334	365	12	to	to	ADP
admet-2334	365	13	bro5	bro5	PROPN
admet-2334	365	14	.	.	PUNCT
admet-2334	366	1	journal	journal	PROPN
admet-2334	366	2	of	of	ADP
admet-2334	366	3	medicinal	medicinal	ADJ
admet-2334	366	4	chemistry	chemistry	NOUN
admet-2334	366	5	65	65	NUM
admet-2334	366	6	(	(	PUNCT
admet-2334	366	7	2022	2022	NUM
admet-2334	366	8	)	)	PUNCT
admet-2334	366	9	12068	12068	NUM
admet-2334	366	10	-	-	SYM
admet-2334	366	11	12083	12083	NUM
admet-2334	366	12	.	.	PUNCT
admet-2334	367	1	https://doi.org/10.1021/acs.jmedchem.2c00774	https://doi.org/10.1021/acs.jmedchem.2c00774	NOUN
admet-2334	367	2	.	.	PUNCT
admet-2334	368	1	[	[	X
admet-2334	368	2	19	19	NUM
admet-2334	368	3	]	]	X
admet-2334	368	4	b.	b.	PROPN
admet-2334	368	5	testa	testa	PROPN
admet-2334	368	6	,	,	PUNCT
admet-2334	368	7	g.	g.	PROPN
admet-2334	368	8	caron	caron	PROPN
admet-2334	368	9	,	,	PUNCT
admet-2334	368	10	p.	p.	PROPN
admet-2334	368	11	crivori	crivori	PROPN
admet-2334	368	12	,	,	PUNCT
admet-2334	368	13	s.	s.	PROPN
admet-2334	368	14	rey	rey	PROPN
admet-2334	368	15	,	,	PUNCT
admet-2334	368	16	m.	m.	NOUN
admet-2334	368	17	reist	reist	PROPN
admet-2334	368	18	,	,	PUNCT
admet-2334	368	19	p.a	p.a	PROPN
admet-2334	368	20	.	.	PUNCT
admet-2334	368	21	carrupt	carrupt	PROPN
admet-2334	368	22	.	.	PUNCT
admet-2334	369	1	lipophilicity	lipophilicity	PROPN
admet-2334	369	2	and	and	CCONJ
admet-2334	369	3	related	relate	VERB
admet-2334	369	4	molecular	molecular	ADJ
admet-2334	369	5	properties	property	NOUN
admet-2334	369	6	as	as	ADP
admet-2334	369	7	determinants	determinant	NOUN
admet-2334	369	8	of	of	ADP
admet-2334	369	9	pharmacokinetic	pharmacokinetic	ADJ
admet-2334	369	10	behavior	behavior	NOUN
admet-2334	369	11	.	.	PUNCT
admet-2334	370	1	chimia	chimia	PROPN
admet-2334	370	2	54	54	NUM
admet-2334	370	3	(	(	PUNCT
admet-2334	370	4	2000	2000	NUM
admet-2334	370	5	)	)	PUNCT
admet-2334	370	6	672	672	NUM
admet-2334	370	7	.	.	PUNCT
admet-2334	371	1	[	[	X
admet-2334	371	2	20	20	NUM
admet-2334	371	3	]	]	PUNCT
admet-2334	371	4	k.	k.	PROPN
admet-2334	371	5	valkó	valkó	PROPN
admet-2334	371	6	,	,	PUNCT
admet-2334	371	7	c.	c.	PROPN
admet-2334	371	8	bevan	bevan	PROPN
admet-2334	371	9	,	,	PUNCT
admet-2334	371	10	d.	d.	PROPN
admet-2334	371	11	reynolds	reynolds	PROPN
admet-2334	371	12	.	.	PUNCT
admet-2334	372	1	chromatographic	chromatographic	ADJ
admet-2334	372	2	hydrophobicity	hydrophobicity	NOUN
admet-2334	372	3	index	index	NOUN
admet-2334	372	4	by	by	ADP
admet-2334	372	5	fast	fast	ADJ
admet-2334	372	6	-	-	PUNCT
admet-2334	372	7	gradient	gradient	NOUN
admet-2334	372	8	rp	rp	NOUN
admet-2334	372	9	-	-	PUNCT
admet-2334	372	10	hplc	hplc	NOUN
admet-2334	372	11	:	:	PUNCT
admet-2334	372	12	a	a	DET
admet-2334	372	13	high	high	ADJ
admet-2334	372	14	-	-	PUNCT
admet-2334	372	15	throughput	throughput	NOUN
admet-2334	372	16	alternative	alternative	NOUN
admet-2334	372	17	to	to	PART
admet-2334	372	18	log	log	VERB
admet-2334	372	19	p	p	NOUN
admet-2334	372	20	/	/	SYM
admet-2334	372	21	log	log	NOUN
admet-2334	372	22	d.	d.	PROPN
admet-2334	372	23	analytical	analytical	ADJ
admet-2334	372	24	chemistry	chemistry	NOUN
admet-2334	372	25	69	69	NUM
admet-2334	372	26	(	(	PUNCT
admet-2334	372	27	1997	1997	NUM
admet-2334	372	28	)	)	PUNCT
admet-2334	372	29	2022	2022	NUM
admet-2334	372	30	-	-	SYM
admet-2334	372	31	2029	2029	NUM
admet-2334	372	32	.	.	PUNCT
admet-2334	373	1	https://doi.org/10.1021/ac961242d	https://doi.org/10.1021/ac961242d	PROPN
admet-2334	373	2	.	.	PUNCT
admet-2334	374	1	[	[	X
admet-2334	374	2	21	21	NUM
admet-2334	374	3	]	]	X
admet-2334	374	4	f.	f.	PROPN
admet-2334	374	5	lombardo	lombardo	PROPN
admet-2334	374	6	,	,	PUNCT
admet-2334	374	7	m.y	m.y	PROPN
admet-2334	374	8	.	.	PROPN
admet-2334	374	9	shalaeva	shalaeva	PROPN
admet-2334	374	10	,	,	PUNCT
admet-2334	374	11	k.a	k.a	PROPN
admet-2334	374	12	tupper	tupper	PROPN
admet-2334	374	13	,	,	PUNCT
admet-2334	374	14	f.	f.	PROPN
admet-2334	374	15	gao	gao	PROPN
admet-2334	374	16	,	,	PUNCT
admet-2334	374	17	m.h	m.h	PROPN
admet-2334	374	18	.	.	PROPN
admet-2334	374	19	abraham	abraham	PROPN
admet-2334	374	20	.	.	PUNCT
admet-2334	375	1	elogpoct	elogpoct	PROPN
admet-2334	375	2	:	:	PUNCT
admet-2334	375	3	a	a	DET
admet-2334	375	4	tool	tool	NOUN
admet-2334	375	5	for	for	ADP
admet-2334	375	6	lipophilicity	lipophilicity	NOUN
admet-2334	375	7	determination	determination	NOUN
admet-2334	375	8	in	in	ADP
admet-2334	375	9	drug	drug	NOUN
admet-2334	375	10	discovery	discovery	NOUN
admet-2334	375	11	.	.	PUNCT
admet-2334	376	1	journal	journal	PROPN
admet-2334	376	2	of	of	ADP
admet-2334	376	3	medicinal	medicinal	ADJ
admet-2334	376	4	chemistry	chemistry	NOUN
admet-2334	376	5	43	43	NUM
admet-2334	376	6	(	(	PUNCT
admet-2334	376	7	2000	2000	NUM
admet-2334	376	8	)	)	PUNCT
admet-2334	376	9	2922	2922	NUM
admet-2334	376	10	-	-	SYM
admet-2334	376	11	2928	2928	NUM
admet-2334	376	12	.	.	PUNCT
admet-2334	377	1	http://www.ncbi.nlm.nih.gov/pubmed/11448232	http://www.ncbi.nlm.nih.gov/pubmed/11448232	X
admet-2334	377	2	.	.	PUNCT
admet-2334	378	1	[	[	X
admet-2334	378	2	22	22	NUM
admet-2334	378	3	]	]	X
admet-2334	378	4	f.	f.	PROPN
admet-2334	378	5	lombardo	lombardo	PROPN
admet-2334	378	6	,	,	PUNCT
admet-2334	378	7	m.y	m.y	PROPN
admet-2334	378	8	.	.	PROPN
admet-2334	378	9	shalaeva	shalaeva	PROPN
admet-2334	378	10	,	,	PUNCT
admet-2334	378	11	k.a	k.a	PROPN
admet-2334	378	12	.	.	PROPN
admet-2334	378	13	tupper	tupper	PROPN
admet-2334	378	14	,	,	PUNCT
admet-2334	378	15	f.	f.	PROPN
admet-2334	378	16	gao	gao	PROPN
admet-2334	378	17	.	.	PUNCT
admet-2334	379	1	elogd	elogd	PROPN
admet-2334	379	2	oct	oct	PROPN
admet-2334	379	3	:	:	PUNCT
admet-2334	379	4	a	a	DET
admet-2334	379	5	tool	tool	NOUN
admet-2334	379	6	for	for	ADP
admet-2334	379	7	lipophilicity	lipophilicity	NOUN
admet-2334	379	8	determination	determination	NOUN
admet-2334	379	9	in	in	ADP
admet-2334	379	10	drug	drug	NOUN
admet-2334	379	11	discovery	discovery	NOUN
admet-2334	379	12	.	.	PUNCT
admet-2334	380	1	2	2	X
admet-2334	380	2	.	.	NUM
admet-2334	380	3	basic	basic	ADJ
admet-2334	380	4	and	and	CCONJ
admet-2334	380	5	neutral	neutral	ADJ
admet-2334	380	6	compounds	compound	NOUN
admet-2334	380	7	.	.	PUNCT
admet-2334	381	1	journal	journal	NOUN
admet-2334	381	2	of	of	ADP
admet-2334	381	3	medicinal	medicinal	ADJ
admet-2334	381	4	chemistry	chemistry	NOUN
admet-2334	381	5	44	44	NUM
admet-2334	381	6	(	(	PUNCT
admet-2334	381	7	2001	2001	NUM
admet-2334	381	8	)	)	PUNCT
admet-2334	381	9	24902497	24902497	NUM
admet-2334	381	10	.	.	PUNCT
admet-2334	382	1	[	[	X
admet-2334	382	2	23	23	NUM
admet-2334	382	3	]	]	X
admet-2334	382	4	g.	g.	NOUN
admet-2334	382	5	ermondi	ermondi	PROPN
admet-2334	382	6	,	,	PUNCT
admet-2334	382	7	m.	m.	NOUN
admet-2334	382	8	vallaro	vallaro	NOUN
admet-2334	382	9	,	,	PUNCT
admet-2334	382	10	g.h	g.h	PROPN
admet-2334	382	11	.	.	PROPN
admet-2334	382	12	goetz	goetz	PROPN
admet-2334	382	13	,	,	PUNCT
admet-2334	382	14	m.	m.	NOUN
admet-2334	382	15	shalaeva	shalaeva	PROPN
admet-2334	382	16	,	,	PUNCT
admet-2334	382	17	g.	g.	PROPN
admet-2334	382	18	caron	caron	PROPN
admet-2334	382	19	.	.	PUNCT
admet-2334	383	1	updating	update	VERB
admet-2334	383	2	the	the	DET
admet-2334	383	3	portfolio	portfolio	NOUN
admet-2334	383	4	of	of	ADP
admet-2334	383	5	physicochemical	physicochemical	ADJ
admet-2334	383	6	descriptors	descriptor	NOUN
admet-2334	383	7	related	relate	VERB
admet-2334	383	8	to	to	ADP
admet-2334	383	9	permeability	permeability	NOUN
admet-2334	383	10	in	in	ADP
admet-2334	383	11	the	the	PRON
admet-2334	383	12	beyond	beyond	ADP
admet-2334	383	13	the	the	DET
admet-2334	383	14	rule	rule	NOUN
admet-2334	383	15	of	of	ADP
admet-2334	383	16	5	5	NUM
admet-2334	383	17	chemical	chemical	NOUN
admet-2334	383	18	space	space	NOUN
admet-2334	383	19	.	.	PUNCT
admet-2334	384	1	european	european	ADJ
admet-2334	384	2	journal	journal	PROPN
admet-2334	384	3	of	of	ADP
admet-2334	384	4	pharmaceutical	pharmaceutical	PROPN
admet-2334	384	5	sciences	science	NOUN
admet-2334	384	6	146	146	NUM
admet-2334	384	7	(	(	PUNCT
admet-2334	384	8	2020	2020	NUM
admet-2334	384	9	)	)	PUNCT
admet-2334	384	10	105274	105274	NUM
admet-2334	384	11	.	.	PUNCT
admet-2334	385	1	https://doi.org/10.1016/j.ejps.2020.105274	https://doi.org/10.1016/j.ejps.2020.105274	NOUN
admet-2334	385	2	.	.	PUNCT
admet-2334	386	1	[	[	X
admet-2334	386	2	24	24	NUM
admet-2334	386	3	]	]	PUNCT
admet-2334	386	4	k.	k.	PROPN
admet-2334	386	5	valko	valko	PROPN
admet-2334	386	6	,	,	PUNCT
admet-2334	386	7	c.m.m	c.m.m	PROPN
admet-2334	386	8	.	.	PUNCT
admet-2334	387	1	du	du	PROPN
admet-2334	387	2	,	,	PUNCT
admet-2334	387	3	c.	c.	PROPN
admet-2334	387	4	bevan	bevan	PROPN
admet-2334	387	5	,	,	PUNCT
admet-2334	387	6	d.p.p	d.p.p	PROPN
admet-2334	387	7	.	.	PUNCT
admet-2334	388	1	reynolds	reynolds	PROPN
admet-2334	388	2	,	,	PUNCT
admet-2334	388	3	m.h.h	m.h.h	PROPN
admet-2334	388	4	.	.	PUNCT
admet-2334	388	5	abraham	abraham	PROPN
admet-2334	388	6	.	.	PUNCT
admet-2334	389	1	rapid	rapid	ADJ
admet-2334	389	2	method	method	NOUN
admet-2334	389	3	for	for	ADP
admet-2334	389	4	the	the	DET
admet-2334	389	5	estimation	estimation	NOUN
admet-2334	389	6	of	of	ADP
admet-2334	389	7	octanol	octanol	NOUN
admet-2334	389	8	/	/	SYM
admet-2334	389	9	water	water	NOUN
admet-2334	389	10	partition	partition	NOUN
admet-2334	389	11	coefficient	coefficient	NOUN
admet-2334	389	12	(	(	PUNCT
admet-2334	389	13	log	log	PROPN
admet-2334	389	14	poct	poct	PROPN
admet-2334	389	15	)	)	PUNCT
admet-2334	389	16	from	from	ADP
admet-2334	389	17	gradient	gradient	ADJ
admet-2334	389	18	rp	rp	NOUN
admet-2334	389	19	-	-	PUNCT
admet-2334	389	20	hplc	hplc	NOUN
admet-2334	389	21	retention	retention	NOUN
admet-2334	389	22	and	and	CCONJ
admet-2334	389	23	a	a	DET
admet-2334	389	24	hydrogen	hydrogen	NOUN
admet-2334	389	25	bond	bond	NOUN
admet-2334	389	26	acidity	acidity	NOUN
admet-2334	389	27	term	term	NOUN
admet-2334	389	28	(	(	PUNCT
admet-2334	389	29	∑α2\nh	∑α2\nh	NOUN
admet-2334	389	30	)	)	PUNCT
admet-2334	389	31	.	.	PUNCT
admet-2334	390	1	current	current	ADJ
admet-2334	390	2	medicinal	medicinal	ADJ
admet-2334	390	3	chemistry	chemistry	NOUN
admet-2334	390	4	8	8	NUM
admet-2334	390	5	(	(	PUNCT
admet-2334	390	6	2001	2001	NUM
admet-2334	390	7	)	)	PUNCT
admet-2334	390	8	1137	1137	NUM
admet-2334	390	9	-	-	SYM
admet-2334	390	10	1146	1146	NUM
admet-2334	390	11	.	.	PUNCT
admet-2334	391	1	https://doi.org/10.2174/0929867013372643	https://doi.org/10.2174/0929867013372643	PROPN
admet-2334	391	2	.	.	PUNCT
admet-2334	392	1	[	[	X
admet-2334	392	2	25	25	NUM
admet-2334	392	3	]	]	X
admet-2334	392	4	g.	g.	PROPN
admet-2334	392	5	caron	caron	PROPN
admet-2334	392	6	,	,	PUNCT
admet-2334	392	7	m.	m.	NOUN
admet-2334	392	8	vallaro	vallaro	NOUN
admet-2334	392	9	,	,	PUNCT
admet-2334	392	10	g.	g.	PROPN
admet-2334	392	11	ermondi	ermondi	PROPN
admet-2334	392	12	.	.	PUNCT
admet-2334	393	1	the	the	DET
admet-2334	393	2	block	block	NOUN
admet-2334	393	3	relevance	relevance	NOUN
admet-2334	393	4	(	(	PUNCT
admet-2334	393	5	br	br	NOUN
admet-2334	393	6	)	)	PUNCT
admet-2334	393	7	analysis	analysis	NOUN
admet-2334	393	8	to	to	PART
admet-2334	393	9	aid	aid	VERB
admet-2334	393	10	medicinal	medicinal	ADJ
admet-2334	393	11	chemists	chemist	NOUN
admet-2334	393	12	to	to	PART
admet-2334	393	13	determine	determine	VERB
admet-2334	393	14	and	and	CCONJ
admet-2334	393	15	interpret	interpret	VERB
admet-2334	393	16	lipophilicity	lipophilicity	NOUN
admet-2334	393	17	.	.	PUNCT
admet-2334	394	1	medicinal	medicinal	ADJ
admet-2334	394	2	chemistry	chemistry	NOUN
admet-2334	394	3	communications	communication	NOUN
admet-2334	394	4	4	4	NUM
admet-2334	394	5	(	(	PUNCT
admet-2334	394	6	2013	2013	NUM
admet-2334	394	7	)	)	PUNCT
admet-2334	394	8	1376	1376	NUM
admet-2334	394	9	.	.	PUNCT
admet-2334	395	1	https://doi.org/10.1039/c3md00140	https://doi.org/10.1039/c3md00140	ADJ
admet-2334	395	2	g.	g.	PROPN
admet-2334	396	1	[	[	X
admet-2334	396	2	26	26	NUM
admet-2334	396	3	]	]	X
admet-2334	396	4	g.	g.	PROPN
admet-2334	396	5	caron	caron	PROPN
admet-2334	396	6	,	,	PUNCT
admet-2334	396	7	m.	m.	NOUN
admet-2334	396	8	vallaro	vallaro	NOUN
admet-2334	396	9	,	,	PUNCT
admet-2334	396	10	g.	g.	PROPN
admet-2334	396	11	ermondi	ermondi	PROPN
admet-2334	396	12	.	.	PUNCT
admet-2334	397	1	the	the	DET
admet-2334	397	2	block	block	NOUN
admet-2334	397	3	relevance	relevance	NOUN
admet-2334	397	4	(	(	PUNCT
admet-2334	397	5	br	br	NOUN
admet-2334	397	6	)	)	PUNCT
admet-2334	397	7	analysis	analysis	NOUN
admet-2334	397	8	makes	make	VERB
admet-2334	397	9	the	the	DET
admet-2334	397	10	choice	choice	NOUN
admet-2334	397	11	of	of	ADP
admet-2334	397	12	methods	method	NOUN
admet-2334	397	13	for	for	ADP
admet-2334	397	14	measuring	measure	VERB
admet-2334	397	15	lipophilicity	lipophilicity	NOUN
admet-2334	397	16	and	and	CCONJ
admet-2334	397	17	permeability	permeability	NOUN
admet-2334	397	18	safer	safe	ADJ
admet-2334	397	19	and	and	CCONJ
admet-2334	397	20	speeds	speed	VERB
admet-2334	397	21	up	up	ADP
admet-2334	397	22	drug	drug	NOUN
admet-2334	397	23	candidate	candidate	NOUN
admet-2334	397	24	prioritization	prioritization	NOUN
admet-2334	397	25	.	.	PUNCT
admet-2334	398	1	current	current	ADJ
admet-2334	398	2	pharmaceutical	pharmaceutical	ADJ
admet-2334	398	3	design	design	NOUN
admet-2334	398	4	26	26	NUM
admet-2334	398	5	(	(	PUNCT
admet-2334	398	6	2020	2020	NUM
admet-2334	398	7	)	)	PUNCT
admet-2334	398	8	5662	5662	NUM
admet-2334	398	9	-	-	SYM
admet-2334	398	10	5667	5667	NUM
admet-2334	398	11	.	.	PUNCT
admet-2334	399	1	https://doi.org/10.2174/1381612826666201109111124	https://doi.org/10.2174/1381612826666201109111124	X
admet-2334	399	2	.	.	PUNCT
admet-2334	400	1	[	[	X
admet-2334	400	2	27	27	NUM
admet-2334	400	3	]	]	X
admet-2334	400	4	c.	c.	NOUN
admet-2334	400	5	pidgeon	pidgeon	PROPN
admet-2334	400	6	,	,	PUNCT
admet-2334	400	7	s.	s.	PROPN
admet-2334	400	8	ong	ong	PROPN
admet-2334	400	9	,	,	PUNCT
admet-2334	400	10	h.	h.	PROPN
admet-2334	400	11	liu	liu	PROPN
admet-2334	400	12	,	,	PUNCT
admet-2334	400	13	x.	x.	PROPN
admet-2334	400	14	qiu	qiu	PROPN
admet-2334	400	15	,	,	PUNCT
admet-2334	400	16	m.	m.	NOUN
admet-2334	400	17	pidgeon	pidgeon	NOUN
admet-2334	400	18	,	,	PUNCT
admet-2334	400	19	a	a	DET
admet-2334	400	20	h.	h.	PROPN
admet-2334	400	21	dantzig	dantzig	PROPN
admet-2334	400	22	,	,	PUNCT
admet-2334	400	23	j.	j.	PROPN
admet-2334	400	24	munroe	munroe	PROPN
admet-2334	400	25	,	,	PUNCT
admet-2334	400	26	w.j	w.j	PROPN
admet-2334	400	27	.	.	PROPN
admet-2334	400	28	hornback	hornback	PROPN
admet-2334	400	29	,	,	PUNCT
admet-2334	400	30	j.s	j.s	PROPN
admet-2334	400	31	.	.	PROPN
admet-2334	400	32	kasher	kasher	PROPN
admet-2334	400	33	,	,	PUNCT
admet-2334	400	34	l.	l.	PROPN
admet-2334	400	35	glunz	glunz	PROPN
admet-2334	400	36	.	.	PUNCT
admet-2334	401	1	iam	iam	PROPN
admet-2334	401	2	chromatography	chromatography	NOUN
admet-2334	401	3	:	:	PUNCT
admet-2334	401	4	an	an	DET
admet-2334	401	5	in	in	ADP
admet-2334	401	6	vitro	vitro	X
admet-2334	401	7	screen	screen	NOUN
admet-2334	401	8	for	for	ADP
admet-2334	401	9	predicting	predict	VERB
admet-2334	401	10	drug	drug	NOUN
admet-2334	401	11	membrane	membrane	NOUN
admet-2334	401	12	permeability	permeability	NOUN
admet-2334	401	13	.	.	PUNCT
admet-2334	402	1	journal	journal	NOUN
admet-2334	402	2	of	of	ADP
admet-2334	402	3	medicinal	medicinal	ADJ
admet-2334	402	4	chemistry	chemistry	NOUN
admet-2334	402	5	38	38	NUM
admet-2334	402	6	(	(	PUNCT
admet-2334	402	7	1995	1995	NUM
admet-2334	402	8	)	)	PUNCT
admet-2334	402	9	590	590	NUM
admet-2334	402	10	-	-	SYM
admet-2334	402	11	594	594	NUM
admet-2334	402	12	.	.	PUNCT
admet-2334	403	1	https://doi.org/10.1021/jm00004a004	https://doi.org/10.1021/jm00004a004	X
admet-2334	403	2	.	.	PUNCT
admet-2334	404	1	https://doi.org/10.1039/c1md00093d	https://doi.org/10.1039/c1md00093d	AUX
admet-2334	405	1	https://doi.org/10.1016/j.bmc.2023.117203	https://doi.org/10.1016/j.bmc.2023.117203	PROPN
admet-2334	405	2	https://doi.org/10.1021/acs.molpharmaceut.5b00910	https://doi.org/10.1021/acs.molpharmaceut.5b00910	AUX
admet-2334	405	3	https://doi.org/10.1021/acs.jmedchem.7b00237	https://doi.org/10.1021/acs.jmedchem.7b00237	PROPN
admet-2334	405	4	https://doi.org/10.1021/ci300010y	https://doi.org/10.1021/ci300010y	PROPN
admet-2334	405	5	https://doi.org/10.1021/acs.jmedchem.2c00774	https://doi.org/10.1021/acs.jmedchem.2c00774	ADV
admet-2334	405	6	https://doi.org/10.1021/ac961242d	https://doi.org/10.1021/ac961242d	PROPN
admet-2334	405	7	http://www.ncbi.nlm.nih.gov/pubmed/11448232	http://www.ncbi.nlm.nih.gov/pubmed/11448232	PROPN
admet-2334	405	8	https://doi.org/10.1016/j.ejps.2020.105274	https://doi.org/10.1016/j.ejps.2020.105274	PROPN
admet-2334	405	9	https://doi.org/10.2174/0929867013372643	https://doi.org/10.2174/0929867013372643	NOUN
admet-2334	405	10	https://doi.org/10.1039/c3md00140	https://doi.org/10.1039/c3md00140	NOUN
admet-2334	405	11	g	g	PRON
admet-2334	405	12	https://doi.org/10.2174/1381612826666201109111124	https://doi.org/10.2174/1381612826666201109111124	NOUN
admet-2334	405	13	https://doi.org/10.1021/jm00004a004	https://doi.org/10.1021/jm00004a004	PROPN
admet-2334	405	14	admet	admet	PROPN
admet-2334	405	15	&	&	CCONJ
admet-2334	405	16	dmpk	dmpk	PROPN
admet-2334	405	17	12(5	12(5	NUM
admet-2334	405	18	)	)	PUNCT
admet-2334	405	19	(	(	PUNCT
admet-2334	405	20	2024	2024	NUM
admet-2334	405	21	)	)	PUNCT
admet-2334	405	22	721	721	NUM
admet-2334	405	23	-	-	NUM
admet-2334	405	24	736	736	NUM
admet-2334	405	25	designing	design	VERB
admet-2334	405	26	the	the	DET
admet-2334	405	27	next	next	ADJ
admet-2334	405	28	generation	generation	NOUN
admet-2334	405	29	of	of	ADP
admet-2334	405	30	oral	oral	ADJ
admet-2334	405	31	beyond	beyond	ADP
admet-2334	405	32	rule	rule	NOUN
admet-2334	405	33	of	of	ADP
admet-2334	405	34	five	five	NUM
admet-2334	405	35	drugs	drug	NOUN
admet-2334	405	36	doi	doi	NOUN
admet-2334	405	37	:	:	PUNCT
admet-2334	405	38	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	NOUN
admet-2334	405	39	735	735	NUM
admet-2334	405	40	[	[	SYM
admet-2334	405	41	28	28	NUM
admet-2334	405	42	]	]	X
admet-2334	405	43	a.	a.	NOUN
admet-2334	405	44	taillardat	taillardat	PROPN
admet-2334	405	45	-	-	PUNCT
admet-2334	405	46	bertschinger	bertschinger	NOUN
admet-2334	405	47	,	,	PUNCT
admet-2334	405	48	p.-a	p.-a	NOUN
admet-2334	405	49	.	.	PUNCT
admet-2334	406	1	carrupt	carrupt	PROPN
admet-2334	406	2	,	,	PUNCT
admet-2334	406	3	f.	f.	PROPN
admet-2334	406	4	barbato	barbato	PROPN
admet-2334	406	5	,	,	PUNCT
admet-2334	406	6	b.	b.	PROPN
admet-2334	406	7	testa	testa	PROPN
admet-2334	406	8	.	.	PUNCT
admet-2334	407	1	immobilized	immobilize	VERB
admet-2334	407	2	artificial	artificial	ADJ
admet-2334	407	3	membrane	membrane	NOUN
admet-2334	407	4	hplc	hplc	NOUN
admet-2334	407	5	in	in	ADP
admet-2334	407	6	drug	drug	NOUN
admet-2334	407	7	research	research	NOUN
admet-2334	407	8	.	.	PUNCT
admet-2334	408	1	journal	journal	NOUN
admet-2334	408	2	of	of	ADP
admet-2334	408	3	medicinal	medicinal	ADJ
admet-2334	408	4	chemistry	chemistry	NOUN
admet-2334	408	5	46	46	NUM
admet-2334	408	6	(	(	PUNCT
admet-2334	408	7	2003	2003	NUM
admet-2334	408	8	)	)	PUNCT
admet-2334	408	9	655	655	NUM
admet-2334	408	10	-	-	SYM
admet-2334	408	11	665	665	NUM
admet-2334	408	12	.	.	PUNCT
admet-2334	409	1	https://doi.org/10.1021/jm020265j	https://doi.org/10.1021/jm020265j	ADJ
admet-2334	409	2	.	.	PUNCT
admet-2334	410	1	[	[	X
admet-2334	410	2	29	29	NUM
admet-2334	410	3	]	]	X
admet-2334	410	4	g.h	g.h	PROPN
admet-2334	410	5	.	.	PROPN
admet-2334	410	6	goetz	goetz	PROPN
admet-2334	410	7	,	,	PUNCT
admet-2334	410	8	w.	w.	PROPN
admet-2334	410	9	farrell	farrell	PROPN
admet-2334	410	10	,	,	PUNCT
admet-2334	410	11	m.	m.	NOUN
admet-2334	410	12	shalaeva	shalaeva	PROPN
admet-2334	410	13	,	,	PUNCT
admet-2334	410	14	s.	s.	PROPN
admet-2334	410	15	sciabola	sciabola	PROPN
admet-2334	410	16	,	,	PUNCT
admet-2334	410	17	d.	d.	PROPN
admet-2334	410	18	anderson	anderson	PROPN
admet-2334	410	19	,	,	PUNCT
admet-2334	410	20	j.	j.	PROPN
admet-2334	410	21	yan	yan	PROPN
admet-2334	410	22	,	,	PUNCT
admet-2334	410	23	l.	l.	PROPN
admet-2334	410	24	philippe	philippe	PROPN
admet-2334	410	25	,	,	PUNCT
admet-2334	410	26	m.j	m.j	PROPN
admet-2334	410	27	.	.	PROPN
admet-2334	410	28	shapiro	shapiro	PROPN
admet-2334	410	29	.	.	PUNCT
admet-2334	411	1	high	high	ADJ
admet-2334	411	2	throughput	throughput	NOUN
admet-2334	411	3	method	method	NOUN
admet-2334	411	4	for	for	ADP
admet-2334	411	5	the	the	DET
admet-2334	411	6	indirect	indirect	ADJ
admet-2334	411	7	detection	detection	NOUN
admet-2334	411	8	of	of	ADP
admet-2334	411	9	intramolecular	intramolecular	ADJ
admet-2334	411	10	hydrogen	hydrogen	NOUN
admet-2334	411	11	bonding	bonding	NOUN
admet-2334	411	12	.	.	PUNCT
admet-2334	412	1	journal	journal	NOUN
admet-2334	412	2	of	of	ADP
admet-2334	412	3	medicinal	medicinal	ADJ
admet-2334	412	4	chemistry	chemistry	NOUN
admet-2334	412	5	57	57	NUM
admet-2334	412	6	(	(	PUNCT
admet-2334	412	7	2014	2014	NUM
admet-2334	412	8	)	)	PUNCT
admet-2334	412	9	2920	2920	NUM
admet-2334	412	10	-	-	SYM
admet-2334	412	11	2929	2929	NUM
admet-2334	412	12	.	.	PUNCT
admet-2334	413	1	https://doi.org/10.1021/jm401859b	https://doi.org/10.1021/jm401859b	PROPN
admet-2334	413	2	.	.	PUNCT
admet-2334	414	1	[	[	X
admet-2334	414	2	30	30	NUM
admet-2334	414	3	]	]	X
admet-2334	414	4	g.h	g.h	PROPN
admet-2334	414	5	.	.	PROPN
admet-2334	414	6	goetz	goetz	PROPN
admet-2334	414	7	,	,	PUNCT
admet-2334	414	8	l.	l.	PROPN
admet-2334	414	9	philippe	philippe	PROPN
admet-2334	414	10	,	,	PUNCT
admet-2334	414	11	m.j	m.j	PROPN
admet-2334	414	12	.	.	PROPN
admet-2334	414	13	shapiro	shapiro	PROPN
admet-2334	414	14	.	.	PUNCT
admet-2334	415	1	epsa	epsa	PROPN
admet-2334	415	2	:	:	PUNCT
admet-2334	415	3	a	a	DET
admet-2334	415	4	novel	novel	ADJ
admet-2334	415	5	supercritical	supercritical	ADJ
admet-2334	415	6	fluid	fluid	NOUN
admet-2334	415	7	chromatography	chromatography	NOUN
admet-2334	415	8	technique	technique	NOUN
admet-2334	415	9	enabling	enable	VERB
admet-2334	415	10	the	the	DET
admet-2334	415	11	design	design	NOUN
admet-2334	415	12	of	of	ADP
admet-2334	415	13	permeable	permeable	ADJ
admet-2334	415	14	cyclic	cyclic	ADJ
admet-2334	415	15	peptides	peptide	NOUN
admet-2334	415	16	.	.	PUNCT
admet-2334	416	1	acs	acs	PROPN
admet-2334	416	2	medicinal	medicinal	ADJ
admet-2334	416	3	chemistry	chemistry	NOUN
admet-2334	416	4	letters	letter	NOUN
admet-2334	416	5	5	5	NUM
admet-2334	416	6	(	(	PUNCT
admet-2334	416	7	2014	2014	NUM
admet-2334	416	8	)	)	PUNCT
admet-2334	416	9	1167	1167	NUM
admet-2334	416	10	-	-	SYM
admet-2334	416	11	72	72	NUM
admet-2334	416	12	.	.	PUNCT
admet-2334	417	1	https://doi.org/10.1021/ml500239	https://doi.org/10.1021/ml500239	VERB
admet-2334	417	2	m.	m.	NOUN
admet-2334	417	3	[	[	X
admet-2334	417	4	31	31	NUM
admet-2334	417	5	]	]	X
admet-2334	417	6	l.	l.	PROPN
admet-2334	417	7	grumetto	grumetto	PROPN
admet-2334	417	8	,	,	PUNCT
admet-2334	417	9	c.	c.	PROPN
admet-2334	417	10	carpentiero	carpentiero	PROPN
admet-2334	417	11	,	,	PUNCT
admet-2334	417	12	f.	f.	PROPN
admet-2334	417	13	barbato	barbato	PROPN
admet-2334	417	14	.	.	PUNCT
admet-2334	418	1	lipophilic	lipophilic	ADJ
admet-2334	418	2	and	and	CCONJ
admet-2334	418	3	electrostatic	electrostatic	ADJ
admet-2334	418	4	forces	force	NOUN
admet-2334	418	5	encoded	encode	VERB
admet-2334	418	6	in	in	ADP
admet-2334	418	7	iam	iam	PROPN
admet-2334	418	8	-	-	PUNCT
admet-2334	418	9	hplc	hplc	NOUN
admet-2334	418	10	indexes	index	NOUN
admet-2334	418	11	of	of	ADP
admet-2334	418	12	basic	basic	ADJ
admet-2334	418	13	drugs	drug	NOUN
admet-2334	418	14	:	:	PUNCT
admet-2334	418	15	their	their	PRON
admet-2334	418	16	role	role	NOUN
admet-2334	418	17	in	in	ADP
admet-2334	418	18	membrane	membrane	NOUN
admet-2334	418	19	partition	partition	NOUN
admet-2334	418	20	and	and	CCONJ
admet-2334	418	21	their	their	PRON
admet-2334	418	22	relationships	relationship	NOUN
admet-2334	418	23	with	with	ADP
admet-2334	418	24	bbb	bbb	PROPN
admet-2334	418	25	passage	passage	NOUN
admet-2334	418	26	data	datum	NOUN
admet-2334	418	27	.	.	PUNCT
admet-2334	419	1	european	european	PROPN
admet-2334	419	2	journal	journal	PROPN
admet-2334	419	3	of	of	ADP
admet-2334	419	4	pharmaceutical	pharmaceutical	PROPN
admet-2334	419	5	sciences	science	NOUN
admet-2334	419	6	45	45	NUM
admet-2334	419	7	(	(	PUNCT
admet-2334	419	8	2012	2012	NUM
admet-2334	419	9	)	)	PUNCT
admet-2334	419	10	685	685	NUM
admet-2334	419	11	-	-	SYM
admet-2334	419	12	692	692	NUM
admet-2334	419	13	.	.	PUNCT
admet-2334	420	1	https://doi.org/10.1016/j.ejps.2012.01.008	https://doi.org/10.1016/j.ejps.2012.01.008	NOUN
admet-2334	420	2	.	.	PUNCT
admet-2334	421	1	[	[	X
admet-2334	421	2	32	32	NUM
admet-2334	421	3	]	]	X
admet-2334	421	4	g.	g.	NOUN
admet-2334	421	5	ermondi	ermondi	PROPN
admet-2334	421	6	,	,	PUNCT
admet-2334	421	7	m.	m.	NOUN
admet-2334	421	8	vallaro	vallaro	NOUN
admet-2334	421	9	,	,	PUNCT
admet-2334	421	10	g.	g.	PROPN
admet-2334	421	11	caron	caron	PROPN
admet-2334	421	12	.	.	PUNCT
admet-2334	422	1	learning	learn	VERB
admet-2334	422	2	how	how	SCONJ
admet-2334	422	3	to	to	PART
admet-2334	422	4	use	use	VERB
admet-2334	422	5	iam	iam	PROPN
admet-2334	422	6	chromatography	chromatography	NOUN
admet-2334	422	7	for	for	ADP
admet-2334	422	8	predicting	predict	VERB
admet-2334	422	9	permeability	permeability	NOUN
admet-2334	422	10	.	.	PUNCT
admet-2334	423	1	european	european	PROPN
admet-2334	423	2	journal	journal	PROPN
admet-2334	423	3	of	of	ADP
admet-2334	423	4	pharmaceutical	pharmaceutical	PROPN
admet-2334	423	5	sciences	science	NOUN
admet-2334	423	6	114	114	NUM
admet-2334	423	7	(	(	PUNCT
admet-2334	423	8	2018	2018	NUM
admet-2334	423	9	)	)	PUNCT
admet-2334	423	10	385	385	NUM
admet-2334	423	11	-	-	SYM
admet-2334	423	12	390	390	NUM
admet-2334	423	13	.	.	PUNCT
admet-2334	423	14	https://doi.org/10.1016/j.ejps.2018.01.001	https://doi.org/10.1016/j.ejps.2018.01.001	VERB
admet-2334	423	15	.	.	PUNCT
admet-2334	424	1	[	[	X
admet-2334	424	2	33	33	NUM
admet-2334	424	3	]	]	X
admet-2334	424	4	g.h	g.h	PROPN
admet-2334	424	5	.	.	PUNCT
admet-2334	424	6	goetz	goetz	PROPN
admet-2334	424	7	,	,	PUNCT
admet-2334	424	8	m.	m.	NOUN
admet-2334	424	9	shalaeva	shalaeva	PROPN
admet-2334	424	10	,	,	PUNCT
admet-2334	424	11	g.	g.	PROPN
admet-2334	424	12	caron	caron	PROPN
admet-2334	424	13	,	,	PUNCT
admet-2334	424	14	g.	g.	PROPN
admet-2334	424	15	ermondi	ermondi	PROPN
admet-2334	424	16	,	,	PUNCT
admet-2334	424	17	l.	l.	PROPN
admet-2334	424	18	philippe	philippe	PROPN
admet-2334	424	19	.	.	PUNCT
admet-2334	425	1	relationship	relationship	NOUN
admet-2334	425	2	between	between	ADP
admet-2334	425	3	passive	passive	ADJ
admet-2334	425	4	permeability	permeability	NOUN
admet-2334	425	5	and	and	CCONJ
admet-2334	425	6	molecular	molecular	ADJ
admet-2334	425	7	polarity	polarity	NOUN
admet-2334	425	8	using	use	VERB
admet-2334	425	9	block	block	NOUN
admet-2334	425	10	relevance	relevance	NOUN
admet-2334	425	11	analysis	analysis	NOUN
admet-2334	425	12	.	.	PUNCT
admet-2334	426	1	molecular	molecular	ADJ
admet-2334	426	2	pharmaceutics	pharmaceutic	NOUN
admet-2334	426	3	14	14	NUM
admet-2334	426	4	(	(	PUNCT
admet-2334	426	5	2017	2017	NUM
admet-2334	426	6	)	)	PUNCT
admet-2334	426	7	acs.molpharmaceut.6b00724	acs.molpharmaceut.6b00724	PROPN
admet-2334	426	8	.	.	PUNCT
admet-2334	427	1	https://doi.org/10.1021/acs.molpharmaceut.6b00724	https://doi.org/10.1021/acs.molpharmaceut.6b00724	X
admet-2334	427	2	.	.	PUNCT
admet-2334	428	1	[	[	X
admet-2334	428	2	34	34	NUM
admet-2334	428	3	]	]	X
admet-2334	428	4	e.	e.	PROPN
admet-2334	428	5	price	price	PROPN
admet-2334	428	6	,	,	PUNCT
admet-2334	428	7	m.	m.	NOUN
admet-2334	428	8	weinheimer	weinheimer	PROPN
admet-2334	428	9	,	,	PUNCT
admet-2334	428	10	a.	a.	NOUN
admet-2334	428	11	rivkin	rivkin	PROPN
admet-2334	428	12	,	,	PUNCT
admet-2334	428	13	g.	g.	PROPN
admet-2334	428	14	jenkins	jenkins	PROPN
admet-2334	428	15	,	,	PUNCT
admet-2334	428	16	m.	m.	NOUN
admet-2334	428	17	nijsen	nijsen	PROPN
admet-2334	428	18	,	,	PUNCT
admet-2334	428	19	p.b	p.b	PROPN
admet-2334	428	20	.	.	PROPN
admet-2334	428	21	cox	cox	PROPN
admet-2334	428	22	,	,	PUNCT
admet-2334	428	23	d.	d.	PROPN
admet-2334	428	24	degoey	degoey	PROPN
admet-2334	428	25	.	.	PUNCT
admet-2334	429	1	beyond	beyond	ADP
admet-2334	429	2	rule	rule	NOUN
admet-2334	429	3	of	of	ADP
admet-2334	429	4	five	five	NUM
admet-2334	429	5	and	and	CCONJ
admet-2334	429	6	protacs	protac	NOUN
admet-2334	429	7	in	in	ADP
admet-2334	429	8	modern	modern	ADJ
admet-2334	429	9	drug	drug	NOUN
admet-2334	429	10	discovery	discovery	NOUN
admet-2334	429	11	:	:	PUNCT
admet-2334	429	12	polarity	polarity	NOUN
admet-2334	429	13	reducers	reducer	NOUN
admet-2334	429	14	,	,	PUNCT
admet-2334	429	15	chameleonicity	chameleonicity	NOUN
admet-2334	429	16	,	,	PUNCT
admet-2334	429	17	and	and	CCONJ
admet-2334	429	18	the	the	DET
admet-2334	429	19	evolving	evolve	VERB
admet-2334	429	20	physicochemical	physicochemical	ADJ
admet-2334	429	21	landscape	landscape	NOUN
admet-2334	429	22	.	.	PUNCT
admet-2334	430	1	journal	journal	NOUN
admet-2334	430	2	of	of	ADP
admet-2334	430	3	medicinal	medicinal	ADJ
admet-2334	430	4	chemistry	chemistry	NOUN
admet-2334	430	5	67	67	NUM
admet-2334	430	6	(	(	PUNCT
admet-2334	430	7	2024	2024	NUM
admet-2334	430	8	)	)	PUNCT
admet-2334	430	9	5683	5683	NUM
admet-2334	430	10	-	-	SYM
admet-2334	430	11	5698	5698	NUM
admet-2334	430	12	.	.	PUNCT
admet-2334	431	1	https://doi.org/10.1021/acs.jmedchem.3c02332	https://doi.org/10.1021/acs.jmedchem.3c02332	X
admet-2334	431	2	.	.	PUNCT
admet-2334	432	1	[	[	X
admet-2334	432	2	35	35	NUM
admet-2334	432	3	]	]	X
admet-2334	432	4	y.t	y.t	PROPN
admet-2334	432	5	.	.	PROPN
admet-2334	432	6	wang	wang	PROPN
admet-2334	432	7	,	,	PUNCT
admet-2334	432	8	e.	e.	PROPN
admet-2334	432	9	price	price	PROPN
admet-2334	432	10	,	,	PUNCT
admet-2334	432	11	m.	m.	NOUN
admet-2334	432	12	feng	feng	PROPN
admet-2334	432	13	,	,	PUNCT
admet-2334	432	14	j.	j.	PROPN
admet-2334	432	15	hulen	hulen	PROPN
admet-2334	432	16	,	,	PUNCT
admet-2334	432	17	s.	s.	PROPN
admet-2334	432	18	doktor	doktor	PROPN
admet-2334	432	19	,	,	PUNCT
admet-2334	432	20	d.m	d.m	PROPN
admet-2334	432	21	.	.	PUNCT
admet-2334	432	22	stresser	stresser	PROPN
admet-2334	432	23	,	,	PUNCT
admet-2334	433	1	e.m	e.m	PROPN
admet-2334	433	2	.	.	PROPN
admet-2334	433	3	maes	maes	PROPN
admet-2334	433	4	,	,	PUNCT
admet-2334	433	5	q.c	q.c	PROPN
admet-2334	433	6	.	.	PROPN
admet-2334	434	1	ji	ji	PROPN
admet-2334	434	2	,	,	PUNCT
admet-2334	434	3	g.j	g.j	PROPN
admet-2334	434	4	.	.	PROPN
admet-2334	434	5	jenkins	jenkins	PROPN
admet-2334	434	6	.	.	PUNCT
admet-2334	435	1	highthroughput	highthroughput	VERB
admet-2334	435	2	sfc	sfc	NOUN
admet-2334	435	3	-	-	PUNCT
admet-2334	435	4	ms	ms	NOUN
admet-2334	435	5	/	/	SYM
admet-2334	435	6	ms	ms	PROPN
admet-2334	435	7	method	method	NOUN
admet-2334	435	8	to	to	PART
admet-2334	435	9	measure	measure	VERB
admet-2334	435	10	epsa	epsa	VERB
admet-2334	435	11	and	and	CCONJ
admet-2334	435	12	predict	predict	VERB
admet-2334	435	13	human	human	ADJ
admet-2334	435	14	permeability	permeability	NOUN
admet-2334	435	15	.	.	PUNCT
admet-2334	436	1	journal	journal	NOUN
admet-2334	436	2	of	of	ADP
admet-2334	436	3	medicinal	medicinal	ADJ
admet-2334	436	4	chemistry	chemistry	NOUN
admet-2334	436	5	2024	2024	NUM
admet-2334	436	6	https://doi.org/10.1021/acs.jmedchem.4c00571	https://doi.org/10.1021/acs.jmedchem.4c00571	NOUN
admet-2334	436	7	.	.	PUNCT
admet-2334	437	1	[	[	X
admet-2334	437	2	36	36	NUM
admet-2334	437	3	]	]	X
admet-2334	437	4	d.a	d.a	PROPN
admet-2334	437	5	.	.	PROPN
admet-2334	437	6	degoey	degoey	PROPN
admet-2334	437	7	,	,	PUNCT
admet-2334	437	8	h.j	h.j	PROPN
admet-2334	437	9	.	.	PROPN
admet-2334	437	10	chen	chen	PROPN
admet-2334	437	11	,	,	PUNCT
admet-2334	437	12	p.b	p.b	PROPN
admet-2334	437	13	.	.	PROPN
admet-2334	437	14	cox	cox	PROPN
admet-2334	437	15	,	,	PUNCT
admet-2334	437	16	m.d	m.d	PROPN
admet-2334	437	17	.	.	PROPN
admet-2334	437	18	wendt	wendt	PROPN
admet-2334	437	19	.	.	PUNCT
admet-2334	438	1	beyond	beyond	ADP
admet-2334	438	2	the	the	DET
admet-2334	438	3	rule	rule	NOUN
admet-2334	438	4	of	of	ADP
admet-2334	438	5	5	5	NUM
admet-2334	438	6	:	:	PUNCT
admet-2334	438	7	lessons	lesson	NOUN
admet-2334	438	8	learned	learn	VERB
admet-2334	438	9	from	from	ADP
admet-2334	438	10	abbvie	abbvie	PROPN
admet-2334	438	11	’s	’s	PART
admet-2334	438	12	drugs	drug	NOUN
admet-2334	438	13	and	and	CCONJ
admet-2334	438	14	compound	compound	NOUN
admet-2334	438	15	collection	collection	NOUN
admet-2334	438	16	.	.	PUNCT
admet-2334	439	1	journal	journal	PROPN
admet-2334	439	2	of	of	ADP
admet-2334	439	3	medicinal	medicinal	ADJ
admet-2334	439	4	chemistry	chemistry	NOUN
admet-2334	439	5	61	61	NUM
admet-2334	439	6	(	(	PUNCT
admet-2334	439	7	2018	2018	NUM
admet-2334	439	8	)	)	PUNCT
admet-2334	439	9	2636	2636	NUM
admet-2334	439	10	-	-	SYM
admet-2334	439	11	2651	2651	NUM
admet-2334	439	12	.	.	PUNCT
admet-2334	440	1	https://doi.org/10.1021/acs.jmedchem.7b00717	https://doi.org/10.1021/acs.jmedchem.7b00717	ADJ
admet-2334	440	2	.	.	PUNCT
admet-2334	441	1	[	[	X
admet-2334	441	2	37	37	NUM
admet-2334	441	3	]	]	PUNCT
admet-2334	441	4	m.	m.	NOUN
admet-2334	441	5	shalaeva	shalaeva	PROPN
admet-2334	441	6	,	,	PUNCT
admet-2334	441	7	g.	g.	PROPN
admet-2334	441	8	caron	caron	PROPN
admet-2334	441	9	,	,	PUNCT
admet-2334	441	10	y.a	y.a	PROPN
admet-2334	441	11	.	.	PROPN
admet-2334	441	12	abramov	abramov	PROPN
admet-2334	441	13	,	,	PUNCT
admet-2334	441	14	t.n.o	t.n.o	PROPN
admet-2334	441	15	.	.	PUNCT
admet-2334	441	16	connell	connell	PROPN
admet-2334	441	17	,	,	PUNCT
admet-2334	441	18	m.s	m.s	PROPN
admet-2334	441	19	.	.	PROPN
admet-2334	441	20	plummer	plummer	PROPN
admet-2334	441	21	,	,	PUNCT
admet-2334	441	22	g.	g.	PROPN
admet-2334	441	23	yalamanchi	yalamanchi	PROPN
admet-2334	441	24	,	,	PUNCT
admet-2334	441	25	k.a	k.a	PROPN
admet-2334	441	26	.	.	PROPN
admet-2334	441	27	farley	farley	PROPN
admet-2334	441	28	,	,	PUNCT
admet-2334	441	29	g.h	g.h	PROPN
admet-2334	441	30	.	.	PROPN
admet-2334	441	31	goetz	goetz	PROPN
admet-2334	441	32	,	,	PUNCT
admet-2334	441	33	l.	l.	PROPN
admet-2334	441	34	philippe	philippe	PROPN
admet-2334	441	35	,	,	PUNCT
admet-2334	441	36	m.j	m.j	PROPN
admet-2334	441	37	.	.	PROPN
admet-2334	441	38	shapiro	shapiro	PROPN
admet-2334	441	39	.	.	PUNCT
admet-2334	442	1	integrating	integrate	VERB
admet-2334	442	2	intramolecular	intramolecular	ADJ
admet-2334	442	3	hydrogen	hydrogen	NOUN
admet-2334	442	4	bonding	bonding	NOUN
admet-2334	442	5	(	(	PUNCT
admet-2334	442	6	imhb	imhb	ADJ
admet-2334	442	7	)	)	PUNCT
admet-2334	442	8	considerations	consideration	NOUN
admet-2334	442	9	in	in	ADP
admet-2334	442	10	drug	drug	NOUN
admet-2334	442	11	discovery	discovery	NOUN
admet-2334	442	12	using	use	VERB
admet-2334	442	13	δ	δ	PROPN
admet-2334	442	14	logp	logp	NOUN
admet-2334	442	15	as	as	ADP
admet-2334	442	16	a	a	DET
admet-2334	442	17	tool	tool	NOUN
admet-2334	442	18	.	.	PUNCT
admet-2334	443	1	journal	journal	NOUN
admet-2334	443	2	of	of	ADP
admet-2334	443	3	medicinal	medicinal	ADJ
admet-2334	443	4	chemistry	chemistry	NOUN
admet-2334	443	5	56	56	NUM
admet-2334	443	6	(	(	PUNCT
admet-2334	443	7	2013	2013	NUM
admet-2334	443	8	)	)	PUNCT
admet-2334	443	9	4870	4870	NUM
admet-2334	443	10	-	-	SYM
admet-2334	443	11	4879	4879	NUM
admet-2334	443	12	.	.	PUNCT
admet-2334	444	1	https://doi.org/10.1021/jm301850	https://doi.org/10.1021/jm301850	NOUN
admet-2334	444	2	m.	m.	NOUN
admet-2334	444	3	[	[	X
admet-2334	444	4	38	38	NUM
admet-2334	444	5	]	]	PUNCT
admet-2334	444	6	m.	m.	NOUN
admet-2334	444	7	rossi	rossi	PROPN
admet-2334	444	8	sebastiano	sebastiano	PROPN
admet-2334	444	9	,	,	PUNCT
admet-2334	444	10	b.c	b.c	PROPN
admet-2334	444	11	.	.	PROPN
admet-2334	444	12	doak	doak	PROPN
admet-2334	444	13	,	,	PUNCT
admet-2334	444	14	m.	m.	NOUN
admet-2334	444	15	backlund	backlund	PROPN
admet-2334	444	16	,	,	PUNCT
admet-2334	444	17	v.	v.	ADP
admet-2334	444	18	poongavanam	poongavanam	PROPN
admet-2334	444	19	,	,	PUNCT
admet-2334	444	20	b.	b.	PROPN
admet-2334	444	21	over	over	PROPN
admet-2334	444	22	,	,	PUNCT
admet-2334	444	23	g.	g.	PROPN
admet-2334	444	24	ermondi	ermondi	PROPN
admet-2334	444	25	,	,	PUNCT
admet-2334	444	26	g.	g.	PROPN
admet-2334	444	27	caron	caron	PROPN
admet-2334	444	28	,	,	PUNCT
admet-2334	444	29	p.	p.	PROPN
admet-2334	444	30	matsson	matsson	PROPN
admet-2334	444	31	,	,	PUNCT
admet-2334	444	32	j.	j.	PROPN
admet-2334	444	33	kihlberg	kihlberg	PROPN
admet-2334	444	34	.	.	PUNCT
admet-2334	445	1	impact	impact	NOUN
admet-2334	445	2	of	of	ADP
admet-2334	445	3	dynamically	dynamically	ADV
admet-2334	445	4	exposed	expose	VERB
admet-2334	445	5	polarity	polarity	NOUN
admet-2334	445	6	on	on	ADP
admet-2334	445	7	permeability	permeability	NOUN
admet-2334	445	8	and	and	CCONJ
admet-2334	445	9	solubility	solubility	NOUN
admet-2334	445	10	of	of	ADP
admet-2334	445	11	chameleonic	chameleonic	ADJ
admet-2334	445	12	drugs	drug	NOUN
admet-2334	445	13	beyond	beyond	ADP
admet-2334	445	14	the	the	DET
admet-2334	445	15	rule	rule	NOUN
admet-2334	445	16	of	of	ADP
admet-2334	445	17	5	5	NUM
admet-2334	445	18	.	.	PUNCT
admet-2334	445	19	journal	journal	PROPN
admet-2334	445	20	of	of	ADP
admet-2334	445	21	medicinal	medicinal	ADJ
admet-2334	445	22	chemistry	chemistry	NOUN
admet-2334	445	23	61	61	NUM
admet-2334	445	24	(	(	PUNCT
admet-2334	445	25	2018	2018	NUM
admet-2334	445	26	)	)	PUNCT
admet-2334	445	27	4189	4189	NUM
admet-2334	445	28	-	-	SYM
admet-2334	445	29	4202	4202	NUM
admet-2334	445	30	.	.	PUNCT
admet-2334	446	1	https://doi.org/10.1021/acs.jmedchem.8b00347	https://doi.org/10.1021/acs.jmedchem.8b00347	INTJ
admet-2334	446	2	.	.	PUNCT
admet-2334	447	1	[	[	X
admet-2334	447	2	39	39	NUM
admet-2334	447	3	]	]	PUNCT
admet-2334	447	4	e.	e.	PROPN
admet-2334	447	5	danelius	danelius	PROPN
admet-2334	447	6	,	,	PUNCT
admet-2334	447	7	v.	v.	ADP
admet-2334	447	8	poongavanam	poongavanam	PROPN
admet-2334	447	9	,	,	PUNCT
admet-2334	447	10	s.	s.	PROPN
admet-2334	447	11	peintner	peintner	PROPN
admet-2334	447	12	,	,	PUNCT
admet-2334	447	13	l.h.e	l.h.e	PROPN
admet-2334	447	14	.	.	PUNCT
admet-2334	447	15	wieske	wieske	PROPN
admet-2334	447	16	,	,	PUNCT
admet-2334	447	17	m.	m.	NOUN
admet-2334	447	18	erdélyi	erdélyi	PROPN
admet-2334	447	19	,	,	PUNCT
admet-2334	447	20	j.	j.	PROPN
admet-2334	447	21	kihlberg	kihlberg	PROPN
admet-2334	447	22	.	.	PUNCT
admet-2334	448	1	solution	solution	NOUN
admet-2334	448	2	conformations	conformation	NOUN
admet-2334	448	3	explain	explain	VERB
admet-2334	448	4	the	the	DET
admet-2334	448	5	chameleonic	chameleonic	ADJ
admet-2334	448	6	behaviour	behaviour	NOUN
admet-2334	448	7	of	of	ADP
admet-2334	448	8	macrocyclic	macrocyclic	ADJ
admet-2334	448	9	drugs	drug	NOUN
admet-2334	448	10	.	.	PUNCT
admet-2334	449	1	chemistry	chemistry	NOUN
admet-2334	449	2	a	a	DET
admet-2334	449	3	european	european	PROPN
admet-2334	449	4	journal	journal	PROPN
admet-2334	449	5	26	26	NUM
admet-2334	449	6	(	(	PUNCT
admet-2334	449	7	2020	2020	NUM
admet-2334	449	8	)	)	PUNCT
admet-2334	449	9	5231	5231	NUM
admet-2334	449	10	-	-	SYM
admet-2334	449	11	5244	5244	NUM
admet-2334	449	12	.	.	PUNCT
admet-2334	449	13	https://doi.org/10.1002/chem.201905599	https://doi.org/10.1002/chem.201905599	X
admet-2334	449	14	.	.	PUNCT
admet-2334	450	1	[	[	X
admet-2334	450	2	40	40	NUM
admet-2334	450	3	]	]	PUNCT
admet-2334	450	4	d.	d.	PROPN
admet-2334	450	5	garcia	garcia	PROPN
admet-2334	450	6	jimenez	jimenez	PROPN
admet-2334	450	7	,	,	PUNCT
admet-2334	450	8	m.	m.	NOUN
admet-2334	450	9	vallaro	vallaro	NOUN
admet-2334	450	10	,	,	PUNCT
admet-2334	450	11	m.	m.	NOUN
admet-2334	450	12	rossi	rossi	PROPN
admet-2334	450	13	sebastiano	sebastiano	PROPN
admet-2334	450	14	,	,	PUNCT
admet-2334	450	15	g.	g.	PROPN
admet-2334	450	16	apprato	apprato	PROPN
admet-2334	450	17	,	,	PUNCT
admet-2334	450	18	g.	g.	PROPN
admet-2334	450	19	d’agostini	d’agostini	PROPN
admet-2334	450	20	,	,	PUNCT
admet-2334	450	21	p.	p.	NOUN
admet-2334	450	22	rossetti	rossetti	NOUN
admet-2334	450	23	,	,	PUNCT
admet-2334	450	24	g.	g.	PROPN
admet-2334	450	25	ermondi	ermondi	PROPN
admet-2334	450	26	,	,	PUNCT
admet-2334	450	27	g.	g.	PROPN
admet-2334	450	28	caron	caron	PROPN
admet-2334	450	29	.	.	PUNCT
admet-2334	451	1	chamelogk	chamelogk	ADJ
admet-2334	451	2	:	:	PUNCT
admet-2334	451	3	a	a	DET
admet-2334	451	4	chromatographic	chromatographic	ADJ
admet-2334	451	5	chameleonicity	chameleonicity	NOUN
admet-2334	451	6	quantifier	quantifier	NOUN
admet-2334	451	7	to	to	PART
admet-2334	451	8	design	design	VERB
admet-2334	451	9	orally	orally	ADV
admet-2334	451	10	bioavailable	bioavailable	ADJ
admet-2334	451	11	beyond	beyond	ADP
admet-2334	451	12	-	-	PUNCT
admet-2334	451	13	rule	rule	NOUN
admet-2334	451	14	-	-	PUNCT
admet-2334	451	15	of-5	of-5	ADP
admet-2334	451	16	drugs	drug	NOUN
admet-2334	451	17	.	.	PUNCT
admet-2334	452	1	journal	journal	NOUN
admet-2334	452	2	of	of	ADP
admet-2334	452	3	medicinal	medicinal	ADJ
admet-2334	452	4	chemistry	chemistry	NOUN
admet-2334	452	5	66	66	NUM
admet-2334	452	6	(	(	PUNCT
admet-2334	452	7	2023	2023	NUM
admet-2334	452	8	)	)	PUNCT
admet-2334	452	9	10681	10681	NUM
admet-2334	452	10	-	-	SYM
admet-2334	452	11	10693	10693	NUM
admet-2334	452	12	.	.	PUNCT
admet-2334	453	1	https://doi.org/10.1021/acs.jmedchem.3c00823	https://doi.org/10.1021/acs.jmedchem.3c00823	X
admet-2334	453	2	.	.	PUNCT
admet-2334	454	1	[	[	X
admet-2334	454	2	41	41	NUM
admet-2334	454	3	]	]	PUNCT
admet-2334	454	4	v.	v.	ADP
admet-2334	454	5	poongavanam	poongavanam	PROPN
admet-2334	454	6	,	,	PUNCT
admet-2334	454	7	l.h.e	l.h.e	PROPN
admet-2334	454	8	.	.	PUNCT
admet-2334	455	1	wieske	wieske	PROPN
admet-2334	455	2	,	,	PUNCT
admet-2334	455	3	s.	s.	PROPN
admet-2334	455	4	peintner	peintner	PROPN
admet-2334	455	5	,	,	PUNCT
admet-2334	455	6	m.	m.	NOUN
admet-2334	455	7	erdélyi	erdélyi	PROPN
admet-2334	455	8	,	,	PUNCT
admet-2334	455	9	j.	j.	PROPN
admet-2334	455	10	kihlberg	kihlberg	PROPN
admet-2334	455	11	.	.	PUNCT
admet-2334	456	1	molecular	molecular	ADJ
admet-2334	456	2	chameleons	chameleon	NOUN
admet-2334	456	3	in	in	ADP
admet-2334	456	4	drug	drug	NOUN
admet-2334	456	5	discovery	discovery	NOUN
admet-2334	456	6	.	.	PUNCT
admet-2334	457	1	nature	nature	NOUN
admet-2334	457	2	reviews	review	VERB
admet-2334	457	3	chemistry	chemistry	NOUN
admet-2334	457	4	8	8	NUM
admet-2334	457	5	(	(	PUNCT
admet-2334	457	6	2024	2024	NUM
admet-2334	457	7	)	)	PUNCT
admet-2334	457	8	45	45	NUM
admet-2334	457	9	-	-	SYM
admet-2334	457	10	60	60	NUM
admet-2334	457	11	.	.	PUNCT
admet-2334	458	1	https://doi.org/10.1038/s41570-023-00563-1	https://doi.org/10.1038/s41570-023-00563-1	NUM
admet-2334	458	2	.	.	PUNCT
admet-2334	459	1	[	[	X
admet-2334	459	2	42	42	NUM
admet-2334	459	3	]	]	X
admet-2334	459	4	d.	d.	PROPN
admet-2334	459	5	garcia	garcia	PROPN
admet-2334	459	6	jimenez	jimenez	PROPN
admet-2334	459	7	,	,	PUNCT
admet-2334	459	8	m.	m.	PROPN
admet-2334	459	9	rossi	rossi	PROPN
admet-2334	459	10	sebastiano	sebastiano	PROPN
admet-2334	459	11	,	,	PUNCT
admet-2334	459	12	m.	m.	NOUN
admet-2334	459	13	vallaro	vallaro	NOUN
admet-2334	459	14	,	,	PUNCT
admet-2334	459	15	g.	g.	PROPN
admet-2334	459	16	ermondi	ermondi	PROPN
admet-2334	459	17	,	,	PUNCT
admet-2334	459	18	g.	g.	PROPN
admet-2334	459	19	caron	caron	PROPN
admet-2334	459	20	.	.	PUNCT
admet-2334	459	21	imhb	imhb	ADJ
admet-2334	459	22	-	-	PUNCT
admet-2334	459	23	mediated	mediate	VERB
admet-2334	459	24	chameleonicity	chameleonicity	NOUN
admet-2334	459	25	in	in	ADP
admet-2334	459	26	drug	drug	NOUN
admet-2334	459	27	design	design	NOUN
admet-2334	459	28	:	:	PUNCT
admet-2334	459	29	a	a	DET
admet-2334	459	30	focus	focus	NOUN
admet-2334	459	31	on	on	ADP
admet-2334	459	32	structurally	structurally	ADV
admet-2334	459	33	related	relate	VERB
admet-2334	459	34	protacs	protac	NOUN
admet-2334	459	35	.	.	PUNCT
admet-2334	460	1	journal	journal	NOUN
admet-2334	460	2	of	of	ADP
admet-2334	460	3	medicinal	medicinal	ADJ
admet-2334	460	4	chemistry	chemistry	NOUN
admet-2334	460	5	67	67	NUM
admet-2334	460	6	(	(	PUNCT
admet-2334	460	7	2024	2024	NUM
admet-2334	460	8	)	)	PUNCT
admet-2334	460	9	11421	11421	NUM
admet-2334	460	10	-	-	SYM
admet-2334	460	11	11434	11434	NUM
admet-2334	460	12	.	.	PUNCT
admet-2334	461	1	https://doi.org/10.1021/acs.jmedchem.4c01200	https://doi.org/10.1021/acs.jmedchem.4c01200	X
admet-2334	461	2	.	.	PUNCT
admet-2334	461	3	https://doi.org/10.5599/admet.2334	https://doi.org/10.5599/admet.2334	X
admet-2334	461	4	https://doi.org/10.1021/jm020265j	https://doi.org/10.1021/jm020265j	PROPN
admet-2334	461	5	https://doi.org/10.1021/jm401859b	https://doi.org/10.1021/jm401859b	X
admet-2334	461	6	https://doi.org/10.1021/ml500239	https://doi.org/10.1021/ml500239	VERB
admet-2334	461	7	m	m	PROPN
admet-2334	461	8	https://doi.org/10.1016/j.ejps.2012.01.008	https://doi.org/10.1016/j.ejps.2012.01.008	NOUN
admet-2334	461	9	https://doi.org/10.1016/j.ejps.2018.01.001	https://doi.org/10.1016/j.ejps.2018.01.001	VERB
admet-2334	461	10	https://doi.org/10.1021/acs.molpharmaceut.6b00724	https://doi.org/10.1021/acs.molpharmaceut.6b00724	NOUN
admet-2334	461	11	https://doi.org/10.1021/acs.jmedchem.3c02332	https://doi.org/10.1021/acs.jmedchem.3c02332	PRON
admet-2334	461	12	https://doi.org/10.1021/acs.jmedchem.4c00571	https://doi.org/10.1021/acs.jmedchem.4c00571	NOUN
admet-2334	461	13	https://doi.org/10.1021/acs.jmedchem.7b00717	https://doi.org/10.1021/acs.jmedchem.7b00717	PRON
admet-2334	461	14	https://doi.org/10.1021/jm301850	https://doi.org/10.1021/jm301850	NOUN
admet-2334	461	15	m	m	VERB
admet-2334	461	16	https://doi.org/10.1021/acs.jmedchem.8b00347	https://doi.org/10.1021/acs.jmedchem.8b00347	ADJ
admet-2334	461	17	https://doi.org/10.1002/chem.201905599	https://doi.org/10.1002/chem.201905599	X
admet-2334	462	1	https://doi.org/10.1021/acs.jmedchem.3c00823	https://doi.org/10.1021/acs.jmedchem.3c00823	PROPN
admet-2334	462	2	https://doi.org/10.1038/s41570-023-00563-1	https://doi.org/10.1038/s41570-023-00563-1	NUM
admet-2334	462	3	https://doi.org/10.1021/acs.jmedchem.4c01200	https://doi.org/10.1021/acs.jmedchem.4c01200	PROPN
admet-2334	463	1	d.	d.	PROPN
admet-2334	463	2	g.	g.	PROPN
admet-2334	464	1	jiménez	jiménez	PROPN
admet-2334	464	2	et	et	PROPN
admet-2334	464	3	al	al	PROPN
admet-2334	464	4	.	.	PROPN
admet-2334	464	5	admet	admet	PROPN
admet-2334	464	6	&	&	CCONJ
admet-2334	464	7	dmpk	dmpk	PROPN
admet-2334	464	8	12(5	12(5	NUM
admet-2334	464	9	)	)	PUNCT
admet-2334	464	10	(	(	PUNCT
admet-2334	464	11	2024	2024	NUM
admet-2334	464	12	)	)	PUNCT
admet-2334	464	13	721	721	NUM
admet-2334	464	14	-	-	NUM
admet-2334	464	15	736	736	NUM
admet-2334	464	16	736	736	NUM
admet-2334	465	1	[	[	X
admet-2334	465	2	43	43	NUM
admet-2334	465	3	]	]	PUNCT
admet-2334	465	4	x.	x.	PROPN
admet-2334	465	5	jia	jia	PROPN
admet-2334	465	6	,	,	PUNCT
admet-2334	465	7	x.	x.	PROPN
admet-2334	465	8	han	han	PROPN
admet-2334	465	9	.	.	PUNCT
admet-2334	466	1	targeting	target	VERB
admet-2334	466	2	androgen	androgen	NOUN
admet-2334	466	3	receptor	receptor	NOUN
admet-2334	466	4	degradation	degradation	NOUN
admet-2334	466	5	with	with	ADP
admet-2334	466	6	protacs	protac	NOUN
admet-2334	466	7	from	from	ADP
admet-2334	466	8	bench	bench	NOUN
admet-2334	466	9	to	to	ADP
admet-2334	466	10	bedside	bedside	NOUN
admet-2334	466	11	.	.	PUNCT
admet-2334	467	1	biomedicine	biomedicine	NOUN
admet-2334	467	2	and	and	CCONJ
admet-2334	467	3	pharmacotherapy	pharmacotherapy	NOUN
admet-2334	467	4	158	158	NUM
admet-2334	467	5	(	(	PUNCT
admet-2334	467	6	2023	2023	NUM
admet-2334	467	7	)	)	PUNCT
admet-2334	467	8	114112	114112	NUM
admet-2334	467	9	.	.	PUNCT
admet-2334	468	1	https://doi.org/10.1016/j.biopha.2022.114112	https://doi.org/10.1016/j.biopha.2022.114112	NOUN
admet-2334	468	2	.	.	PUNCT
admet-2334	469	1	[	[	X
admet-2334	469	2	44	44	NUM
admet-2334	469	3	]	]	SYM
admet-2334	469	4	e.p	e.p	PROPN
admet-2334	469	5	.	.	PROPN
admet-2334	469	6	hamilton	hamilton	PROPN
admet-2334	469	7	,	,	PUNCT
admet-2334	469	8	h.	h.	PROPN
admet-2334	469	9	han	han	PROPN
admet-2334	469	10	,	,	PUNCT
admet-2334	469	11	a.	a.	NOUN
admet-2334	469	12	schott	schott	PROPN
admet-2334	469	13	,	,	PUNCT
admet-2334	469	14	a.	a.	PROPN
admet-2334	469	15	tan	tan	PROPN
admet-2334	469	16	,	,	PUNCT
admet-2334	469	17	r.	r.	PROPN
admet-2334	469	18	nanda	nanda	PROPN
admet-2334	469	19	,	,	PUNCT
admet-2334	469	20	d.	d.	PROPN
admet-2334	469	21	jurić	jurić	PROPN
admet-2334	469	22	,	,	PUNCT
admet-2334	469	23	n.	n.	NOUN
admet-2334	469	24	hunter	hunter	NOUN
admet-2334	469	25	,	,	PUNCT
admet-2334	469	26	p.	p.	PROPN
admet-2334	469	27	munster	munster	PROPN
admet-2334	469	28	,	,	PUNCT
admet-2334	469	29	b.	b.	PROPN
admet-2334	469	30	fang	fang	PROPN
admet-2334	469	31	,	,	PUNCT
admet-2334	469	32	g.	g.	PROPN
admet-2334	469	33	zahrah	zahrah	PROPN
admet-2334	469	34	,	,	PUNCT
admet-2334	469	35	j.	j.	PROPN
admet-2334	469	36	ranciato	ranciato	PROPN
admet-2334	469	37	,	,	PUNCT
admet-2334	469	38	r.	r.	PROPN
admet-2334	469	39	gedrich	gedrich	PROPN
admet-2334	469	40	,	,	PUNCT
admet-2334	469	41	e.	e.	PROPN
admet-2334	469	42	zhi	zhi	PROPN
admet-2334	469	43	,	,	PUNCT
admet-2334	469	44	y.	y.	PROPN
admet-2334	469	45	zhang	zhang	PROPN
admet-2334	469	46	,	,	PUNCT
admet-2334	469	47	w.	w.	PROPN
admet-2334	469	48	tan	tan	PROPN
admet-2334	469	49	,	,	PUNCT
admet-2334	469	50	c.	c.	PROPN
admet-2334	469	51	mather	mather	PROPN
admet-2334	469	52	,	,	PUNCT
admet-2334	469	53	j.	j.	PROPN
admet-2334	469	54	perkins	perkins	PROPN
admet-2334	469	55	,	,	PUNCT
admet-2334	469	56	s.	s.	PROPN
admet-2334	469	57	anderson	anderson	PROPN
admet-2334	469	58	,	,	PUNCT
admet-2334	469	59	s.a	s.a	PROPN
admet-2334	469	60	.	.	PROPN
admet-2334	469	61	hurvitz	hurvitz	PROPN
admet-2334	469	62	.	.	PUNCT
admet-2334	470	1	390p	390p	NOUN
admet-2334	470	2	vepdegestrant	vepdegestrant	NOUN
admet-2334	470	3	,	,	PUNCT
admet-2334	470	4	a	a	DET
admet-2334	470	5	proteolysis	proteolysis	NOUN
admet-2334	470	6	targeting	target	VERB
admet-2334	470	7	chimera	chimera	NOUN
admet-2334	470	8	(	(	PUNCT
admet-2334	470	9	protac	protac	ADJ
admet-2334	470	10	)	)	PUNCT
admet-2334	470	11	estrogen	estrogen	NOUN
admet-2334	470	12	receptor	receptor	NOUN
admet-2334	470	13	(	(	PUNCT
admet-2334	470	14	er	er	INTJ
admet-2334	470	15	)	)	PUNCT
admet-2334	470	16	degrader	degrader	NOUN
admet-2334	470	17	,	,	PUNCT
admet-2334	470	18	in	in	ADP
admet-2334	470	19	er+/human	er+/human	PROPN
admet-2334	470	20	epidermal	epidermal	ADJ
admet-2334	470	21	growth	growth	NOUN
admet-2334	470	22	factor	factor	NOUN
admet-2334	470	23	receptor	receptor	NOUN
admet-2334	470	24	2	2	NUM
admet-2334	470	25	(	(	PUNCT
admet-2334	470	26	her2)advanced	her2)advance	VERB
admet-2334	470	27	breast	breast	NOUN
admet-2334	470	28	cancer	cancer	NOUN
admet-2334	470	29	:	:	PUNCT
admet-2334	470	30	update	update	NOUN
admet-2334	470	31	of	of	ADP
admet-2334	470	32	dose	dose	NOUN
admet-2334	470	33	escalation	escalation	NOUN
admet-2334	470	34	results	result	VERB
admet-2334	470	35	from	from	ADP
admet-2334	470	36	a	a	DET
admet-2334	470	37	phase	phase	NOUN
admet-2334	470	38	i	i	PRON
admet-2334	470	39	/	/	SYM
admet-2334	470	40	ii	ii	PROPN
admet-2334	470	41	trial	trial	NOUN
admet-2334	470	42	.	.	PUNCT
admet-2334	471	1	annals	annal	NOUN
admet-2334	471	2	of	of	ADP
admet-2334	471	3	oncology	oncology	NOUN
admet-2334	471	4	34	34	NUM
admet-2334	471	5	(	(	PUNCT
admet-2334	471	6	2023	2023	NUM
admet-2334	471	7	)	)	PUNCT
admet-2334	471	8	s344	s344	NUM
admet-2334	471	9	.	.	PUNCT
admet-2334	472	1	https://doi.org/10.1016/j.annonc.2023.09.567	https://doi.org/10.1016/j.annonc.2023.09.567	PROPN
admet-2334	472	2	.	.	PUNCT
admet-2334	473	1	[	[	X
admet-2334	473	2	45	45	NUM
admet-2334	473	3	]	]	X
admet-2334	473	4	y.	y.	NOUN
admet-2334	473	5	he	he	PRON
admet-2334	473	6	,	,	PUNCT
admet-2334	473	7	r.	r.	PROPN
admet-2334	473	8	koch	koch	PROPN
admet-2334	473	9	,	,	PUNCT
admet-2334	473	10	v.	v.	ADP
admet-2334	473	11	budamagunta	budamagunta	PROPN
admet-2334	473	12	,	,	PUNCT
admet-2334	473	13	p.	p.	PROPN
admet-2334	473	14	zhang	zhang	PROPN
admet-2334	473	15	,	,	PUNCT
admet-2334	473	16	x.	x.	PROPN
admet-2334	473	17	zhang	zhang	PROPN
admet-2334	473	18	,	,	PUNCT
admet-2334	473	19	s.	s.	PROPN
admet-2334	473	20	khan	khan	PROPN
admet-2334	473	21	,	,	PUNCT
admet-2334	473	22	d.	d.	PROPN
admet-2334	473	23	thummuri	thummuri	PROPN
admet-2334	473	24	,	,	PUNCT
admet-2334	473	25	y.t	y.t	PROPN
admet-2334	473	26	.	.	PROPN
admet-2334	473	27	ortiz	ortiz	PROPN
admet-2334	473	28	,	,	PUNCT
admet-2334	473	29	x.	x.	PROPN
admet-2334	473	30	zhang	zhang	PROPN
admet-2334	473	31	,	,	PUNCT
admet-2334	473	32	d.	d.	PROPN
admet-2334	473	33	lv	lv	PROPN
admet-2334	473	34	,	,	PUNCT
admet-2334	473	35	j.s	j.s	PROPN
admet-2334	473	36	.	.	PROPN
admet-2334	473	37	wiegand	wiegand	PROPN
admet-2334	473	38	,	,	PUNCT
admet-2334	473	39	w.	w.	PROPN
admet-2334	473	40	li	li	PROPN
admet-2334	473	41	,	,	PUNCT
admet-2334	473	42	a.c	a.c	PROPN
admet-2334	473	43	.	.	PROPN
admet-2334	473	44	palmer	palmer	PROPN
admet-2334	473	45	,	,	PUNCT
admet-2334	473	46	g.	g.	PROPN
admet-2334	473	47	zheng	zheng	PROPN
admet-2334	473	48	,	,	PUNCT
admet-2334	473	49	d.m	d.m	PROPN
admet-2334	473	50	.	.	PROPN
admet-2334	473	51	weinstock	weinstock	PROPN
admet-2334	473	52	,	,	PUNCT
admet-2334	473	53	d.	d.	PROPN
admet-2334	473	54	zhou	zhou	PROPN
admet-2334	473	55	.	.	PUNCT
admet-2334	473	56	dt2216	dt2216	PROPN
admet-2334	473	57	a	a	DET
admet-2334	473	58	bcl	bcl	PROPN
admet-2334	473	59	-	-	PUNCT
admet-2334	473	60	xl	xl	PROPN
admet-2334	473	61	-	-	PUNCT
admet-2334	473	62	specific	specific	ADJ
admet-2334	473	63	degrader	degrader	NOUN
admet-2334	473	64	is	be	AUX
admet-2334	473	65	highly	highly	ADV
admet-2334	473	66	active	active	ADJ
admet-2334	473	67	against	against	ADP
admet-2334	473	68	bcl	bcl	PROPN
admet-2334	473	69	-	-	PUNCT
admet-2334	473	70	xl	xl	PROPN
admet-2334	473	71	-	-	PUNCT
admet-2334	473	72	dependent	dependent	ADJ
admet-2334	473	73	t	t	NOUN
admet-2334	473	74	cell	cell	NOUN
admet-2334	473	75	lymphomas	lymphoma	NOUN
admet-2334	473	76	.	.	PUNCT
admet-2334	474	1	journal	journal	PROPN
admet-2334	474	2	of	of	ADP
admet-2334	474	3	hematology	hematology	PROPN
admet-2334	474	4	&	&	CCONJ
admet-2334	474	5	oncology	oncology	NOUN
admet-2334	474	6	13	13	NUM
admet-2334	474	7	(	(	PUNCT
admet-2334	474	8	2020	2020	NUM
admet-2334	474	9	)	)	PUNCT
admet-2334	474	10	.	.	PUNCT
admet-2334	475	1	https://doi.org/10.1186/s13045-020-00928-9	https://doi.org/10.1186/s13045-020-00928-9	PROPN
admet-2334	475	2	.	.	PUNCT
admet-2334	476	1	[	[	X
admet-2334	476	2	46	46	NUM
admet-2334	476	3	]	]	X
admet-2334	476	4	g.	g.	PROPN
admet-2334	476	5	apprato	apprato	PROPN
admet-2334	476	6	,	,	PUNCT
admet-2334	476	7	v.	v.	ADP
admet-2334	476	8	poongavanam	poongavanam	PROPN
admet-2334	476	9	,	,	PUNCT
admet-2334	476	10	d.g	d.g	PROPN
admet-2334	476	11	.	.	PROPN
admet-2334	476	12	jimenez	jimenez	PROPN
admet-2334	476	13	,	,	PUNCT
admet-2334	476	14	y.	y.	PROPN
admet-2334	476	15	atilaw	atilaw	PROPN
admet-2334	476	16	,	,	PUNCT
admet-2334	476	17	m.	m.	NOUN
admet-2334	476	18	erdelyi	erdelyi	NOUN
admet-2334	476	19	,	,	PUNCT
admet-2334	476	20	g.	g.	PROPN
admet-2334	476	21	ermondi	ermondi	PROPN
admet-2334	476	22	,	,	PUNCT
admet-2334	476	23	g.	g.	PROPN
admet-2334	476	24	caron	caron	PROPN
admet-2334	476	25	,	,	PUNCT
admet-2334	476	26	j.	j.	PROPN
admet-2334	476	27	kihlberg	kihlberg	PROPN
admet-2334	476	28	.	.	PUNCT
admet-2334	477	1	exploring	explore	VERB
admet-2334	477	2	the	the	DET
admet-2334	477	3	chemical	chemical	ADJ
admet-2334	477	4	space	space	NOUN
admet-2334	477	5	of	of	ADP
admet-2334	477	6	orally	orally	ADV
admet-2334	477	7	bioavailable	bioavailable	ADJ
admet-2334	477	8	protacs	protac	NOUN
admet-2334	477	9	.	.	PUNCT
admet-2334	478	1	drug	drug	NOUN
admet-2334	478	2	discovery	discovery	PROPN
admet-2334	478	3	today	today	NOUN
admet-2334	478	4	29	29	NUM
admet-2334	478	5	(	(	PUNCT
admet-2334	478	6	2024	2024	NUM
admet-2334	478	7	)	)	PUNCT
admet-2334	478	8	103917	103917	NUM
admet-2334	478	9	.	.	PUNCT
admet-2334	479	1	https://doi.org/10.1016/j.drudis.2024.103917	https://doi.org/10.1016/j.drudis.2024.103917	NOUN
admet-2334	479	2	.	.	PUNCT
admet-2334	480	1	[	[	X
admet-2334	480	2	47	47	NUM
admet-2334	480	3	]	]	X
admet-2334	480	4	k.r	k.r	PROPN
admet-2334	480	5	.	.	PROPN
admet-2334	480	6	hornberger	hornberger	NOUN
admet-2334	480	7	,	,	PUNCT
admet-2334	480	8	e.m.v	e.m.v	PROPN
admet-2334	480	9	.	.	PUNCT
admet-2334	480	10	araujo	araujo	PROPN
admet-2334	480	11	.	.	PUNCT
admet-2334	481	1	physicochemical	physicochemical	ADJ
admet-2334	481	2	property	property	NOUN
admet-2334	481	3	determinants	determinant	NOUN
admet-2334	481	4	of	of	ADP
admet-2334	481	5	oral	oral	ADJ
admet-2334	481	6	absorption	absorption	NOUN
admet-2334	481	7	for	for	ADP
admet-2334	481	8	protac	protac	ADJ
admet-2334	481	9	protein	protein	NOUN
admet-2334	481	10	degraders	degrader	NOUN
admet-2334	481	11	.	.	PUNCT
admet-2334	482	1	journal	journal	NOUN
admet-2334	482	2	of	of	ADP
admet-2334	482	3	medicinal	medicinal	ADJ
admet-2334	482	4	chemistry	chemistry	NOUN
admet-2334	482	5	66	66	NUM
admet-2334	482	6	(	(	PUNCT
admet-2334	482	7	2023	2023	NUM
admet-2334	482	8	)	)	PUNCT
admet-2334	482	9	8281	8281	NUM
admet-2334	482	10	-	-	SYM
admet-2334	482	11	8287	8287	NUM
admet-2334	482	12	.	.	PUNCT
admet-2334	483	1	https://doi.org/10.1021/acs.jmedchem.3c00740	https://doi.org/10.1021/acs.jmedchem.3c00740	NOUN
admet-2334	483	2	.	.	PUNCT
admet-2334	484	1	[	[	X
admet-2334	484	2	48	48	NUM
admet-2334	484	3	]	]	PUNCT
admet-2334	484	4	g.	g.	NOUN
admet-2334	484	5	ermondi	ermondi	PROPN
admet-2334	484	6	,	,	PUNCT
admet-2334	484	7	d.g	d.g	PROPN
admet-2334	484	8	.	.	PROPN
admet-2334	484	9	jimenez	jimenez	PROPN
admet-2334	484	10	,	,	PUNCT
admet-2334	484	11	m.	m.	PROPN
admet-2334	484	12	rossi	rossi	PROPN
admet-2334	484	13	sebastiano	sebastiano	PROPN
admet-2334	484	14	,	,	PUNCT
admet-2334	484	15	j.	j.	PROPN
admet-2334	484	16	kihlberg	kihlberg	PROPN
admet-2334	484	17	,	,	PUNCT
admet-2334	484	18	g.	g.	PROPN
admet-2334	484	19	caron	caron	PROPN
admet-2334	484	20	.	.	PUNCT
admet-2334	485	1	conformational	conformational	ADJ
admet-2334	485	2	sampling	sampling	NOUN
admet-2334	485	3	deciphers	decipher	VERB
admet-2334	485	4	the	the	DET
admet-2334	485	5	chameleonic	chameleonic	ADJ
admet-2334	485	6	properties	property	NOUN
admet-2334	485	7	of	of	ADP
admet-2334	485	8	a	a	DET
admet-2334	485	9	vhl	vhl	NOUN
admet-2334	485	10	-	-	PUNCT
admet-2334	485	11	based	base	VERB
admet-2334	485	12	degrader	degrader	NOUN
admet-2334	485	13	.	.	PUNCT
admet-2334	486	1	pharmaceutics	pharmaceutic	NOUN
admet-2334	486	2	15	15	NUM
admet-2334	486	3	(	(	PUNCT
admet-2334	486	4	2023	2023	NUM
admet-2334	486	5	)	)	PUNCT
admet-2334	486	6	272	272	NUM
admet-2334	486	7	.	.	PUNCT
admet-2334	487	1	https://doi.org/10.3390/pharmaceutics15010272	https://doi.org/10.3390/pharmaceutics15010272	PROPN
admet-2334	487	2	.	.	PUNCT
admet-2334	488	1	©	©	ADP
admet-2334	488	2	2024	2024	NUM
admet-2334	488	3	by	by	ADP
admet-2334	488	4	the	the	DET
admet-2334	488	5	authors	author	NOUN
admet-2334	488	6	;	;	PUNCT
admet-2334	488	7	licensee	licensee	PROPN
admet-2334	488	8	iapc	iapc	PROPN
admet-2334	488	9	,	,	PUNCT
admet-2334	488	10	zagreb	zagreb	PROPN
admet-2334	488	11	,	,	PUNCT
admet-2334	488	12	croatia	croatia	PROPN
admet-2334	488	13	.	.	PUNCT
admet-2334	489	1	this	this	DET
admet-2334	489	2	article	article	NOUN
admet-2334	489	3	is	be	AUX
admet-2334	489	4	an	an	DET
admet-2334	489	5	open	open	ADJ
admet-2334	489	6	-	-	PUNCT
admet-2334	489	7	access	access	NOUN
admet-2334	489	8	article	article	NOUN
admet-2334	489	9	distributed	distribute	VERB
admet-2334	489	10	under	under	ADP
admet-2334	489	11	the	the	DET
admet-2334	489	12	terms	term	NOUN
admet-2334	489	13	and	and	CCONJ
admet-2334	489	14	conditions	condition	NOUN
admet-2334	489	15	of	of	ADP
admet-2334	489	16	the	the	DET
admet-2334	489	17	creative	creative	ADJ
admet-2334	489	18	commons	common	NOUN
admet-2334	489	19	attribution	attribution	NOUN
admet-2334	489	20	license	license	NOUN
admet-2334	489	21	(	(	PUNCT
admet-2334	489	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN
admet-2334	489	23	)	)	PUNCT
admet-2334	489	24	https://doi.org/10.1016/j.biopha.2022.114112	https://doi.org/10.1016/j.biopha.2022.114112	PROPN
admet-2334	489	25	https://doi.org/10.1016/j.annonc.2023.09.567	https://doi.org/10.1016/j.annonc.2023.09.567	PROPN
admet-2334	489	26	https://doi.org/10.1186/s13045-020-00928-9	https://doi.org/10.1186/s13045-020-00928-9	PROPN
admet-2334	489	27	https://doi.org/10.1016/j.drudis.2024.103917	https://doi.org/10.1016/j.drudis.2024.103917	NOUN
admet-2334	489	28	https://doi.org/10.1021/acs.jmedchem.3c00740	https://doi.org/10.1021/acs.jmedchem.3c00740	PRON
admet-2334	489	29	https://doi.org/10.3390/pharmaceutics15010272	https://doi.org/10.3390/pharmaceutics15010272	VERB
admet-2334	489	30	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN