id	sid	tid	token	lemma	pos
admet-2387	1	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	1	2	and	and	CCONJ
admet-2387	1	3	metabolism	metabolism	NOUN
admet-2387	1	4	of	of	ADP
admet-2387	1	5	ketoconazole	ketoconazole	NOUN
admet-2387	1	6	after	after	ADP
admet-2387	1	7	single	single	ADJ
admet-2387	1	8	ocular	ocular	ADJ
admet-2387	1	9	instillation	instillation	NOUN
admet-2387	1	10	in	in	ADP
admet-2387	1	11	sprague	sprague	NOUN
admet-2387	1	12	-	-	PUNCT
admet-2387	1	13	dawley	dawley	NOUN
admet-2387	1	14	rats	rat	NOUN
admet-2387	1	15	doi	doi	NOUN
admet-2387	1	16	:	:	PUNCT
admet-2387	1	17	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	1	18	943	943	NUM
admet-2387	1	19	admet	admet	X
admet-2387	1	20	&	&	CCONJ
admet-2387	1	21	dmpk	dmpk	PROPN
admet-2387	1	22	12(6	12(6	NUM
admet-2387	1	23	)	)	PUNCT
admet-2387	1	24	(	(	PUNCT
admet-2387	1	25	2024	2024	NUM
admet-2387	1	26	)	)	PUNCT
admet-2387	1	27	943	943	NUM
admet-2387	1	28	-	-	SYM
admet-2387	1	29	955	955	NUM
admet-2387	1	30	;	;	PUNCT
admet-2387	1	31	doi	doi	NOUN
admet-2387	1	32	:	:	PUNCT
admet-2387	1	33	https://doi.org/10.5599/admet.2387	https://doi.org/10.5599/admet.2387	PROPN
admet-2387	1	34	open	open	ADJ
admet-2387	1	35	access	access	NOUN
admet-2387	1	36	:	:	PUNCT
admet-2387	1	37	issn	issn	PROPN
admet-2387	1	38	:	:	PUNCT
admet-2387	1	39	1848	1848	NUM
admet-2387	1	40	-	-	SYM
admet-2387	1	41	7718	7718	NUM
admet-2387	1	42	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2387	1	43	original	original	ADJ
admet-2387	1	44	scientific	scientific	ADJ
admet-2387	1	45	paper	paper	NOUN
admet-2387	1	46	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	1	47	and	and	CCONJ
admet-2387	1	48	metabolism	metabolism	NOUN
admet-2387	1	49	of	of	ADP
admet-2387	1	50	ketoconazole	ketoconazole	NOUN
admet-2387	1	51	after	after	ADP
admet-2387	1	52	single	single	ADJ
admet-2387	1	53	ocular	ocular	ADJ
admet-2387	1	54	instillation	instillation	NOUN
admet-2387	1	55	in	in	ADP
admet-2387	1	56	sprague	sprague	NOUN
admet-2387	1	57	-	-	PUNCT
admet-2387	1	58	dawley	dawley	NOUN
admet-2387	1	59	rats	rat	NOUN
admet-2387	1	60	jiang	jiang	PROPN
admet-2387	1	61	pu	pu	PROPN
admet-2387	1	62	,	,	PUNCT
admet-2387	1	63	jinsong	jinsong	PROPN
admet-2387	1	64	he	he	PRON
admet-2387	1	65	,	,	PUNCT
admet-2387	1	66	ru	ru	PROPN
admet-2387	1	67	xue	xue	PROPN
admet-2387	1	68	,	,	PUNCT
admet-2387	1	69	ruiqi	ruiqi	PROPN
admet-2387	1	70	gao	gao	PROPN
admet-2387	1	71	,	,	PUNCT
admet-2387	1	72	yaoming	yaoming	PROPN
admet-2387	1	73	yu	yu	PROPN
admet-2387	1	74	and	and	CCONJ
admet-2387	1	75	wanyong	wanyong	PROPN
admet-2387	1	76	feng	feng	PROPN
admet-2387	1	77	*	*	PUNCT
admet-2387	1	78	bioduro	bioduro	NOUN
admet-2387	1	79	-	-	PUNCT
admet-2387	1	80	sundia	sundia	PROPN
admet-2387	1	81	,	,	PUNCT
admet-2387	1	82	shanghai	shanghai	PROPN
admet-2387	1	83	,	,	PUNCT
admet-2387	1	84	china	china	PROPN
admet-2387	1	85	*	*	PUNCT
admet-2387	1	86	corresponding	correspond	VERB
admet-2387	1	87	author	author	NOUN
admet-2387	1	88	:	:	PUNCT
admet-2387	1	89	e	e	NOUN
admet-2387	1	90	-	-	NOUN
admet-2387	1	91	mail	mail	NOUN
admet-2387	1	92	:	:	PUNCT
admet-2387	1	93	wanyong.feng@bioduro-sundia.com	wanyong.feng@bioduro-sundia.com	X
admet-2387	1	94	;	;	PUNCT
admet-2387	1	95	tel	tel	PROPN
admet-2387	1	96	.	.	PUNCT
admet-2387	1	97	:	:	PUNCT
admet-2387	2	1	+86	+86	PROPN
admet-2387	2	2	-	-	PUNCT
admet-2387	2	3	021	021	NUM
admet-2387	2	4	-	-	PUNCT
admet-2387	2	5	31751005	31751005	NUM
admet-2387	2	6	received	receive	VERB
admet-2387	2	7	:	:	PUNCT
admet-2387	2	8	august	august	PROPN
admet-2387	2	9	03	03	NUM
admet-2387	2	10	,	,	PUNCT
admet-2387	2	11	2024	2024	NUM
admet-2387	2	12	;	;	PUNCT
admet-2387	2	13	revised	revise	VERB
admet-2387	2	14	:	:	PUNCT
admet-2387	2	15	october	october	PROPN
admet-2387	2	16	17	17	NUM
admet-2387	2	17	,	,	PUNCT
admet-2387	2	18	2024	2024	NUM
admet-2387	2	19	;	;	PUNCT
admet-2387	2	20	published	publish	VERB
admet-2387	2	21	:	:	PUNCT
admet-2387	2	22	november	november	PROPN
admet-2387	2	23	9,2024	9,2024	NUM
admet-2387	2	24	abstract	abstract	ADJ
admet-2387	2	25	background	background	NOUN
admet-2387	2	26	and	and	CCONJ
admet-2387	2	27	purpose	purpose	NOUN
admet-2387	2	28	:	:	PUNCT
admet-2387	2	29	ketoconazole	ketoconazole	PROPN
admet-2387	2	30	is	be	AUX
admet-2387	2	31	limited	limit	VERB
admet-2387	2	32	to	to	ADP
admet-2387	2	33	its	its	PRON
admet-2387	2	34	conditioned	condition	VERB
admet-2387	2	35	oral	oral	ADJ
admet-2387	2	36	use	use	NOUN
admet-2387	2	37	due	due	ADP
admet-2387	2	38	to	to	ADP
admet-2387	2	39	hepatic	hepatic	ADJ
admet-2387	2	40	toxicity	toxicity	NOUN
admet-2387	2	41	.	.	PUNCT
admet-2387	3	1	its	its	PRON
admet-2387	3	2	ocular	ocular	ADJ
admet-2387	3	3	eye	eye	NOUN
admet-2387	3	4	drop	drop	NOUN
admet-2387	3	5	administration	administration	NOUN
admet-2387	3	6	may	may	AUX
admet-2387	3	7	be	be	AUX
admet-2387	3	8	an	an	DET
admet-2387	3	9	option	option	NOUN
admet-2387	3	10	for	for	ADP
admet-2387	3	11	mycotic	mycotic	ADJ
admet-2387	3	12	keratitis	keratitis	NOUN
admet-2387	3	13	treatment	treatment	NOUN
admet-2387	3	14	.	.	PUNCT
admet-2387	4	1	therefore	therefore	ADV
admet-2387	4	2	,	,	PUNCT
admet-2387	4	3	it	it	PRON
admet-2387	4	4	is	be	AUX
admet-2387	4	5	necessary	necessary	ADJ
admet-2387	4	6	to	to	PART
admet-2387	4	7	explore	explore	VERB
admet-2387	4	8	its	its	PRON
admet-2387	4	9	pharmacokinetic	pharmacokinetic	ADJ
admet-2387	4	10	and	and	CCONJ
admet-2387	4	11	metabolic	metabolic	NOUN
admet-2387	4	12	profile	profile	NOUN
admet-2387	4	13	via	via	ADP
admet-2387	4	14	topical	topical	ADJ
admet-2387	4	15	ocular	ocular	ADJ
admet-2387	4	16	administration	administration	NOUN
admet-2387	4	17	.	.	PUNCT
admet-2387	5	1	experimental	experimental	ADJ
admet-2387	5	2	approach	approach	NOUN
admet-2387	5	3	:	:	PUNCT
admet-2387	5	4	nine	nine	NUM
admet-2387	5	5	rats	rat	NOUN
admet-2387	5	6	were	be	AUX
admet-2387	5	7	dosed	dose	VERB
admet-2387	5	8	at	at	ADP
admet-2387	5	9	300	300	NUM
admet-2387	5	10	µg	µg	ADJ
admet-2387	5	11	/	/	SYM
admet-2387	5	12	rat	rat	NOUN
admet-2387	5	13	via	via	ADP
admet-2387	5	14	topical	topical	ADJ
admet-2387	5	15	ocular	ocular	ADJ
admet-2387	5	16	administration	administration	NOUN
admet-2387	5	17	,	,	PUNCT
admet-2387	5	18	and	and	CCONJ
admet-2387	5	19	sacrificed	sacrifice	VERB
admet-2387	5	20	at	at	ADP
admet-2387	5	21	5	5	NUM
admet-2387	5	22	,	,	PUNCT
admet-2387	5	23	30	30	NUM
admet-2387	5	24	,	,	PUNCT
admet-2387	5	25	and	and	CCONJ
admet-2387	5	26	120	120	NUM
admet-2387	5	27	min	min	NOUN
admet-2387	5	28	with	with	ADP
admet-2387	5	29	3	3	NUM
admet-2387	5	30	rats	rat	NOUN
admet-2387	5	31	/	/	SYM
admet-2387	5	32	timepoint	timepoint	NOUN
admet-2387	5	33	.	.	PUNCT
admet-2387	6	1	plasma	plasma	NOUN
admet-2387	6	2	,	,	PUNCT
admet-2387	6	3	cornea	cornea	NOUN
admet-2387	6	4	,	,	PUNCT
admet-2387	6	5	retina	retina	NOUN
admet-2387	6	6	,	,	PUNCT
admet-2387	6	7	and	and	CCONJ
admet-2387	6	8	vitreous	vitreous	ADJ
admet-2387	6	9	humour	humour	NOUN
admet-2387	6	10	samples	sample	NOUN
admet-2387	6	11	were	be	AUX
admet-2387	6	12	collected	collect	VERB
admet-2387	6	13	,	,	PUNCT
admet-2387	6	14	processed	process	VERB
admet-2387	6	15	,	,	PUNCT
admet-2387	6	16	and	and	CCONJ
admet-2387	6	17	analysed	analyse	VERB
admet-2387	6	18	.	.	PUNCT
admet-2387	7	1	key	key	ADJ
admet-2387	7	2	results	result	NOUN
admet-2387	7	3	:	:	PUNCT
admet-2387	7	4	ketoconazole	ketoconazole	PROPN
admet-2387	7	5	was	be	AUX
admet-2387	7	6	quantified	quantify	VERB
admet-2387	7	7	with	with	ADP
admet-2387	7	8	a	a	DET
admet-2387	7	9	mean	mean	ADJ
admet-2387	7	10	peak	peak	NOUN
admet-2387	7	11	plasma	plasma	NOUN
admet-2387	7	12	concentration	concentration	NOUN
admet-2387	7	13	of	of	ADP
admet-2387	7	14	445	445	NUM
admet-2387	7	15	ng	ng	NOUN
admet-2387	7	16	/	/	SYM
admet-2387	7	17	ml	ml	X
admet-2387	7	18	at	at	ADP
admet-2387	7	19	5	5	NUM
admet-2387	7	20	min	min	NOUN
admet-2387	7	21	post	post	NOUN
admet-2387	7	22	-	-	NOUN
admet-2387	7	23	dose	dose	NOUN
admet-2387	7	24	.	.	PUNCT
admet-2387	8	1	in	in	ADP
admet-2387	8	2	the	the	DET
admet-2387	8	3	rat	rat	NOUN
admet-2387	8	4	ocular	ocular	ADJ
admet-2387	8	5	tissue	tissue	NOUN
admet-2387	8	6	,	,	PUNCT
admet-2387	8	7	the	the	DET
admet-2387	8	8	mean	mean	ADJ
admet-2387	8	9	ketoconazole	ketoconazole	NOUN
admet-2387	8	10	concentration	concentration	NOUN
admet-2387	8	11	at	at	ADP
admet-2387	8	12	5	5	NUM
admet-2387	8	13	min	min	NOUN
admet-2387	8	14	post	post	ADJ
admet-2387	8	15	-	-	ADJ
admet-2387	8	16	dose	dose	ADJ
admet-2387	8	17	was	be	AUX
admet-2387	8	18	423	423	NUM
admet-2387	8	19	μg	μg	PROPN
admet-2387	8	20	/	/	SYM
admet-2387	8	21	g	g	NOUN
admet-2387	8	22	in	in	ADP
admet-2387	8	23	the	the	DET
admet-2387	8	24	cornea	cornea	NOUN
admet-2387	8	25	,	,	PUNCT
admet-2387	8	26	4.96	4.96	NUM
admet-2387	8	27	μg	μg	NOUN
admet-2387	8	28	/	/	SYM
admet-2387	8	29	g	g	NOUN
admet-2387	8	30	in	in	ADP
admet-2387	8	31	the	the	DET
admet-2387	8	32	retina	retina	NOUN
admet-2387	8	33	,	,	PUNCT
admet-2387	8	34	and	and	CCONJ
admet-2387	8	35	1.19	1.19	NUM
admet-2387	8	36	μg	μg	NOUN
admet-2387	8	37	/	/	SYM
admet-2387	8	38	g	g	NOUN
admet-2387	8	39	in	in	ADP
admet-2387	8	40	the	the	DET
admet-2387	8	41	vitreous	vitreous	ADJ
admet-2387	8	42	humour	humour	NOUN
admet-2387	8	43	,	,	PUNCT
admet-2387	8	44	respectively	respectively	ADV
admet-2387	8	45	.	.	PUNCT
admet-2387	9	1	the	the	DET
admet-2387	9	2	mean	mean	ADJ
admet-2387	9	3	ketoconazole	ketoconazole	NOUN
admet-2387	9	4	concentration	concentration	NOUN
admet-2387	9	5	in	in	ADP
admet-2387	9	6	each	each	DET
admet-2387	9	7	matrix	matrix	NOUN
admet-2387	9	8	decreased	decrease	VERB
admet-2387	9	9	from	from	ADP
admet-2387	9	10	5	5	NUM
admet-2387	9	11	to	to	PART
admet-2387	9	12	120	120	NUM
admet-2387	9	13	min	min	NOUN
admet-2387	9	14	.	.	PUNCT
admet-2387	10	1	the	the	DET
admet-2387	10	2	mean	mean	ADJ
admet-2387	10	3	ketoconazole	ketoconazole	NOUN
admet-2387	10	4	concentration	concentration	NOUN
admet-2387	10	5	at	at	ADP
admet-2387	10	6	120	120	NUM
admet-2387	10	7	min	min	NOUN
admet-2387	10	8	was	be	AUX
admet-2387	10	9	38.4	38.4	NUM
admet-2387	10	10	ng	ng	NOUN
admet-2387	10	11	/	/	SYM
admet-2387	10	12	ml	ml	X
admet-2387	10	13	in	in	ADP
admet-2387	10	14	plasma	plasma	NOUN
admet-2387	10	15	,	,	PUNCT
admet-2387	10	16	and	and	CCONJ
admet-2387	10	17	8.36	8.36	NUM
admet-2387	10	18	,	,	PUNCT
admet-2387	10	19	0.0944	0.0944	NUM
admet-2387	10	20	,	,	PUNCT
admet-2387	10	21	and	and	CCONJ
admet-2387	10	22	0.116	0.116	NUM
admet-2387	10	23	μg	μg	PROPN
admet-2387	10	24	/	/	SYM
admet-2387	10	25	g	g	NOUN
admet-2387	10	26	in	in	ADP
admet-2387	10	27	the	the	DET
admet-2387	10	28	cornea	cornea	NOUN
admet-2387	10	29	,	,	PUNCT
admet-2387	10	30	retina	retina	NOUN
admet-2387	10	31	,	,	PUNCT
admet-2387	10	32	and	and	CCONJ
admet-2387	10	33	vitreous	vitreous	ADJ
admet-2387	10	34	humour	humour	NOUN
admet-2387	10	35	,	,	PUNCT
admet-2387	10	36	respectively	respectively	ADV
admet-2387	10	37	.	.	PUNCT
admet-2387	11	1	pooled	pool	VERB
admet-2387	11	2	plasma	plasma	NOUN
admet-2387	11	3	,	,	PUNCT
admet-2387	11	4	cornea	cornea	NOUN
admet-2387	11	5	,	,	PUNCT
admet-2387	11	6	retina	retina	NOUN
admet-2387	11	7	,	,	PUNCT
admet-2387	11	8	and	and	CCONJ
admet-2387	11	9	vitreous	vitreous	ADJ
admet-2387	11	10	humour	humour	NOUN
admet-2387	11	11	homogenates	homogenate	NOUN
admet-2387	11	12	were	be	AUX
admet-2387	11	13	used	use	VERB
admet-2387	11	14	for	for	ADP
admet-2387	11	15	metabolite	metabolite	NOUN
admet-2387	11	16	identification	identification	NOUN
admet-2387	11	17	.	.	PUNCT
admet-2387	12	1	nine	nine	NUM
admet-2387	12	2	metabolites	metabolite	NOUN
admet-2387	12	3	were	be	AUX
admet-2387	12	4	identified	identify	VERB
admet-2387	12	5	in	in	ADP
admet-2387	12	6	rat	rat	NOUN
admet-2387	12	7	plasma	plasma	NOUN
admet-2387	12	8	,	,	PUNCT
admet-2387	12	9	and	and	CCONJ
admet-2387	12	10	o	o	X
admet-2387	12	11	-	-	ADJ
admet-2387	12	12	dealkylated	dealkylated	ADJ
admet-2387	12	13	metabolite	metabolite	NOUN
admet-2387	12	14	(	(	PUNCT
admet-2387	12	15	m3	m3	PROPN
admet-2387	12	16	)	)	PUNCT
admet-2387	12	17	and	and	CCONJ
admet-2387	12	18	dehydrogenated	dehydrogenated	ADJ
admet-2387	12	19	metabolite	metabolite	NOUN
admet-2387	12	20	(	(	PUNCT
admet-2387	12	21	m11	m11	NOUN
admet-2387	12	22	)	)	PUNCT
admet-2387	12	23	were	be	AUX
admet-2387	12	24	the	the	DET
admet-2387	12	25	top	top	ADJ
admet-2387	12	26	two	two	NUM
admet-2387	12	27	,	,	PUNCT
admet-2387	12	28	accounting	account	VERB
admet-2387	12	29	for	for	ADP
admet-2387	12	30	5.0	5.0	NUM
admet-2387	12	31	and	and	CCONJ
admet-2387	12	32	5.8	5.8	NUM
admet-2387	12	33	%	%	NOUN
admet-2387	12	34	of	of	ADP
admet-2387	12	35	the	the	DET
admet-2387	12	36	relative	relative	ADJ
admet-2387	12	37	mass	mass	PROPN
admet-2387	12	38	abundance	abundance	NOUN
admet-2387	12	39	.	.	PUNCT
admet-2387	13	1	the	the	DET
admet-2387	13	2	metabolic	metabolic	NOUN
admet-2387	13	3	pathways	pathway	NOUN
admet-2387	13	4	were	be	AUX
admet-2387	13	5	o	o	NOUN
admet-2387	13	6	-	-	NOUN
admet-2387	13	7	dealkylation	dealkylation	NOUN
admet-2387	13	8	,	,	PUNCT
admet-2387	13	9	mono	mono	NOUN
admet-2387	13	10	-	-	PUNCT
admet-2387	13	11	oxygenation	oxygenation	NOUN
admet-2387	13	12	,	,	PUNCT
admet-2387	13	13	and	and	CCONJ
admet-2387	13	14	dehydrogenation	dehydrogenation	NOUN
admet-2387	13	15	.	.	PUNCT
admet-2387	14	1	eleven	eleven	NUM
admet-2387	14	2	metabolites	metabolite	NOUN
admet-2387	14	3	were	be	AUX
admet-2387	14	4	identified	identify	VERB
admet-2387	14	5	in	in	ADP
admet-2387	14	6	the	the	DET
admet-2387	14	7	rat	rat	NOUN
admet-2387	14	8	cornea	cornea	NOUN
admet-2387	14	9	,	,	PUNCT
admet-2387	14	10	and	and	CCONJ
admet-2387	14	11	two	two	NUM
admet-2387	14	12	metabolites	metabolite	NOUN
admet-2387	14	13	were	be	AUX
admet-2387	14	14	identified	identify	VERB
admet-2387	14	15	in	in	ADP
admet-2387	14	16	the	the	DET
admet-2387	14	17	rat	rat	NOUN
admet-2387	14	18	retina	retina	NOUN
admet-2387	14	19	and	and	CCONJ
admet-2387	14	20	vitreous	vitreous	ADJ
admet-2387	14	21	humour	humour	NOUN
admet-2387	14	22	,	,	PUNCT
admet-2387	14	23	respectively	respectively	ADV
admet-2387	14	24	.	.	PUNCT
admet-2387	15	1	the	the	DET
admet-2387	15	2	o	o	NOUN
admet-2387	15	3	-	-	ADJ
admet-2387	15	4	dealkylated	dealkylated	ADJ
admet-2387	15	5	and	and	CCONJ
admet-2387	15	6	hydrogenated	hydrogenated	ADJ
admet-2387	15	7	metabolite	metabolite	NOUN
admet-2387	15	8	(	(	PUNCT
admet-2387	15	9	m2	m2	PROPN
admet-2387	15	10	)	)	PUNCT
admet-2387	15	11	was	be	AUX
admet-2387	15	12	a	a	DET
admet-2387	15	13	dominant	dominant	ADJ
admet-2387	15	14	metabolite	metabolite	NOUN
admet-2387	15	15	in	in	ADP
admet-2387	15	16	the	the	DET
admet-2387	15	17	cornea	cornea	NOUN
admet-2387	15	18	,	,	PUNCT
admet-2387	15	19	retina	retina	NOUN
admet-2387	15	20	,	,	PUNCT
admet-2387	15	21	and	and	CCONJ
admet-2387	15	22	vitreous	vitreous	ADJ
admet-2387	15	23	humour	humour	NOUN
admet-2387	15	24	,	,	PUNCT
admet-2387	15	25	while	while	SCONJ
admet-2387	15	26	m3	m3	PROPN
admet-2387	15	27	and	and	CCONJ
admet-2387	15	28	m11	m11	PROPN
admet-2387	15	29	were	be	AUX
admet-2387	15	30	the	the	DET
admet-2387	15	31	dominant	dominant	ADJ
admet-2387	15	32	metabolites	metabolite	NOUN
admet-2387	15	33	in	in	ADP
admet-2387	15	34	plasma	plasma	NOUN
admet-2387	15	35	.	.	PUNCT
admet-2387	16	1	conclusion	conclusion	NOUN
admet-2387	16	2	:	:	PUNCT
admet-2387	16	3	ketoconazole	ketoconazole	PROPN
admet-2387	16	4	was	be	AUX
admet-2387	16	5	a	a	DET
admet-2387	16	6	dominant	dominant	ADJ
admet-2387	16	7	component	component	NOUN
admet-2387	16	8	(	(	PUNCT
admet-2387	16	9	≥	≥	NUM
admet-2387	16	10	98.5	98.5	NUM
admet-2387	16	11	%	%	NOUN
admet-2387	16	12	)	)	PUNCT
admet-2387	16	13	in	in	ADP
admet-2387	16	14	the	the	DET
admet-2387	16	15	cornea	cornea	NOUN
admet-2387	16	16	,	,	PUNCT
admet-2387	16	17	retina	retina	NOUN
admet-2387	16	18	,	,	PUNCT
admet-2387	16	19	and	and	CCONJ
admet-2387	16	20	vitreous	vitreous	ADJ
admet-2387	16	21	humour	humour	NOUN
admet-2387	16	22	,	,	PUNCT
admet-2387	16	23	having	have	VERB
admet-2387	16	24	higher	high	ADJ
admet-2387	16	25	concentrations	concentration	NOUN
admet-2387	16	26	in	in	ADP
admet-2387	16	27	cornea	cornea	NOUN
admet-2387	16	28	than	than	ADP
admet-2387	16	29	in	in	ADP
admet-2387	16	30	plasma	plasma	NOUN
admet-2387	16	31	.	.	PUNCT
admet-2387	17	1	m2	m2	PROPN
admet-2387	17	2	was	be	AUX
admet-2387	17	3	identified	identify	VERB
admet-2387	17	4	as	as	ADP
admet-2387	17	5	a	a	DET
admet-2387	17	6	dominant	dominant	ADJ
admet-2387	17	7	metabolite	metabolite	NOUN
admet-2387	17	8	(	(	PUNCT
admet-2387	17	9	1.1	1.1	NUM
admet-2387	17	10	1.2	1.2	NUM
admet-2387	17	11	%	%	NOUN
admet-2387	17	12	)	)	PUNCT
admet-2387	17	13	in	in	ADP
admet-2387	17	14	the	the	DET
admet-2387	17	15	cornea	cornea	NOUN
admet-2387	17	16	,	,	PUNCT
admet-2387	17	17	retina	retina	VERB
admet-2387	17	18	,	,	PUNCT
admet-2387	17	19	while	while	SCONJ
admet-2387	17	20	m3	m3	PROPN
admet-2387	17	21	(	(	PUNCT
admet-2387	17	22	5.0	5.0	NUM
admet-2387	17	23	%	%	NOUN
admet-2387	17	24	)	)	PUNCT
admet-2387	17	25	and	and	CCONJ
admet-2387	17	26	m11	m11	NOUN
admet-2387	17	27	(	(	PUNCT
admet-2387	17	28	5.8	5.8	NUM
admet-2387	17	29	%	%	NOUN
admet-2387	17	30	)	)	PUNCT
admet-2387	17	31	were	be	AUX
admet-2387	17	32	identified	identify	VERB
admet-2387	17	33	as	as	ADP
admet-2387	17	34	dominant	dominant	ADJ
admet-2387	17	35	metabolites	metabolite	NOUN
admet-2387	17	36	in	in	ADP
admet-2387	17	37	the	the	DET
admet-2387	17	38	plasma	plasma	NOUN
admet-2387	17	39	.	.	PUNCT
admet-2387	18	1	©	©	ADP
admet-2387	18	2	2024	2024	NUM
admet-2387	18	3	by	by	ADP
admet-2387	18	4	the	the	DET
admet-2387	18	5	authors	author	NOUN
admet-2387	18	6	.	.	PUNCT
admet-2387	19	1	this	this	DET
admet-2387	19	2	article	article	NOUN
admet-2387	19	3	is	be	AUX
admet-2387	19	4	an	an	DET
admet-2387	19	5	open	open	ADJ
admet-2387	19	6	-	-	PUNCT
admet-2387	19	7	access	access	NOUN
admet-2387	19	8	article	article	NOUN
admet-2387	19	9	distributed	distribute	VERB
admet-2387	19	10	under	under	ADP
admet-2387	19	11	the	the	DET
admet-2387	19	12	terms	term	NOUN
admet-2387	19	13	and	and	CCONJ
admet-2387	19	14	conditions	condition	NOUN
admet-2387	19	15	of	of	ADP
admet-2387	19	16	the	the	DET
admet-2387	19	17	creative	creative	ADJ
admet-2387	19	18	commons	common	NOUN
admet-2387	19	19	attribution	attribution	NOUN
admet-2387	19	20	license	license	NOUN
admet-2387	19	21	(	(	PUNCT
admet-2387	19	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2387	19	23	)	)	PUNCT
admet-2387	19	24	.	.	PUNCT
admet-2387	20	1	keywords	keyword	NOUN
admet-2387	20	2	plasma	plasma	NOUN
admet-2387	20	3	;	;	PUNCT
admet-2387	20	4	cornea	cornea	NOUN
admet-2387	20	5	;	;	PUNCT
admet-2387	20	6	retina	retina	NOUN
admet-2387	20	7	;	;	PUNCT
admet-2387	20	8	quantitation	quantitation	NOUN
admet-2387	20	9	;	;	PUNCT
admet-2387	20	10	metabolite	metabolite	NOUN
admet-2387	20	11	identification	identification	NOUN
admet-2387	20	12	;	;	PUNCT
admet-2387	20	13	mass	mass	ADJ
admet-2387	20	14	spectrometry	spectrometry	NOUN
admet-2387	20	15	introduction	introduction	NOUN
admet-2387	20	16	mycotic	mycotic	ADJ
admet-2387	20	17	keratitis	keratitis	NOUN
admet-2387	20	18	is	be	AUX
admet-2387	20	19	a	a	DET
admet-2387	20	20	common	common	ADJ
admet-2387	20	21	disease	disease	NOUN
admet-2387	20	22	in	in	ADP
admet-2387	20	23	ophthalmology	ophthalmology	NOUN
admet-2387	20	24	.	.	PUNCT
admet-2387	21	1	its	its	PRON
admet-2387	21	2	symptoms	symptom	NOUN
admet-2387	21	3	are	be	AUX
admet-2387	21	4	not	not	PART
admet-2387	21	5	typical	typical	ADJ
admet-2387	21	6	in	in	ADP
admet-2387	21	7	the	the	DET
admet-2387	21	8	early	early	ADJ
admet-2387	21	9	stages	stage	NOUN
admet-2387	21	10	.	.	PUNCT
admet-2387	22	1	fusarium	fusarium	NOUN
admet-2387	22	2	and	and	CCONJ
admet-2387	22	3	curvularia	curvularia	NOUN
admet-2387	22	4	are	be	AUX
admet-2387	22	5	the	the	DET
admet-2387	22	6	major	major	ADJ
admet-2387	22	7	pathogens	pathogen	NOUN
admet-2387	22	8	in	in	ADP
admet-2387	22	9	river	river	NOUN
admet-2387	22	10	districts	district	NOUN
admet-2387	22	11	,	,	PUNCT
admet-2387	22	12	and	and	CCONJ
admet-2387	22	13	once	once	ADV
admet-2387	22	14	infected	infect	VERB
admet-2387	22	15	,	,	PUNCT
admet-2387	22	16	they	they	PRON
admet-2387	22	17	could	could	AUX
admet-2387	22	18	severely	severely	ADV
admet-2387	22	19	affect	affect	VERB
admet-2387	22	20	vision	vision	NOUN
admet-2387	22	21	.	.	PUNCT
admet-2387	23	1	ketoconazole	ketoconazole	PROPN
admet-2387	23	2	is	be	AUX
admet-2387	23	3	a	a	DET
admet-2387	23	4	drug	drug	NOUN
admet-2387	23	5	used	use	VERB
admet-2387	23	6	in	in	ADP
admet-2387	23	7	the	the	DET
admet-2387	23	8	management	management	NOUN
admet-2387	23	9	and	and	CCONJ
admet-2387	23	10	treatment	treatment	NOUN
admet-2387	23	11	of	of	ADP
admet-2387	23	12	fungal	fungal	ADJ
admet-2387	23	13	infections	infection	NOUN
admet-2387	23	14	.	.	PUNCT
admet-2387	24	1	as	as	ADP
admet-2387	24	2	a	a	DET
admet-2387	24	3	dioxolane	dioxolane	NOUN
admet-2387	24	4	imidazole	imidazole	NOUN
admet-2387	24	5	[	[	X
admet-2387	24	6	1,2	1,2	NUM
admet-2387	24	7	]	]	PUNCT
admet-2387	24	8	,	,	PUNCT
admet-2387	24	9	ketoconazole	ketoconazole	PROPN
admet-2387	24	10	inhibits	inhibit	VERB
admet-2387	24	11	sterol	sterol	NOUN
admet-2387	24	12	biosynthesis	biosynthesis	NOUN
admet-2387	24	13	in	in	ADP
admet-2387	24	14	the	the	DET
admet-2387	24	15	fungal	fungal	ADJ
admet-2387	24	16	membrane	membrane	NOUN
admet-2387	24	17	[	[	X
admet-2387	24	18	3	3	NUM
admet-2387	24	19	]	]	PUNCT
admet-2387	24	20	.	.	PUNCT
admet-2387	25	1	this	this	DET
admet-2387	25	2	inhibition	inhibition	NOUN
admet-2387	25	3	could	could	AUX
admet-2387	25	4	deprive	deprive	VERB
admet-2387	25	5	the	the	DET
admet-2387	25	6	fungal	fungal	ADJ
admet-2387	25	7	cell	cell	NOUN
admet-2387	25	8	of	of	ADP
admet-2387	25	9	its	its	PRON
admet-2387	25	10	protective	protective	ADJ
admet-2387	25	11	sterol	sterol	NOUN
admet-2387	25	12	membrane	membrane	NOUN
admet-2387	25	13	,	,	PUNCT
admet-2387	25	14	making	make	VERB
admet-2387	25	15	ketoconazole	ketoconazole	NOUN
admet-2387	25	16	widely	widely	ADV
admet-2387	25	17	accepted	accept	VERB
admet-2387	25	18	and	and	CCONJ
admet-2387	25	19	used	use	VERB
admet-2387	25	20	as	as	ADP
admet-2387	25	21	a	a	DET
admet-2387	25	22	broad	broad	ADJ
admet-2387	25	23	-	-	PUNCT
admet-2387	25	24	spectrum	spectrum	NOUN
admet-2387	25	25	drug	drug	NOUN
admet-2387	25	26	to	to	PART
admet-2387	25	27	treat	treat	VERB
admet-2387	25	28	mycotic	mycotic	ADJ
admet-2387	25	29	keratitis	keratitis	NOUN
admet-2387	25	30	.	.	PUNCT
admet-2387	26	1	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	26	2	https://doi.org/10.5599/admet.2387	https://doi.org/10.5599/admet.2387	PROPN
admet-2387	26	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2387	26	4	mailto:wanyong.feng@bioduro-sundia.com	mailto:wanyong.feng@bioduro-sundia.com	X
admet-2387	27	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2387	27	2	j.	j.	PROPN
admet-2387	27	3	pu	pu	PROPN
admet-2387	27	4	et	et	PROPN
admet-2387	27	5	al	al	PROPN
admet-2387	27	6	.	.	PROPN
admet-2387	27	7	admet	admet	PROPN
admet-2387	27	8	&	&	CCONJ
admet-2387	27	9	dmpk	dmpk	PROPN
admet-2387	27	10	12(6	12(6	NUM
admet-2387	27	11	)	)	PUNCT
admet-2387	27	12	(	(	PUNCT
admet-2387	27	13	2024	2024	NUM
admet-2387	27	14	)	)	PUNCT
admet-2387	27	15	943	943	NUM
admet-2387	27	16	-	-	SYM
admet-2387	27	17	955	955	NUM
admet-2387	27	18	944	944	NUM
admet-2387	27	19	ketoconazole	ketoconazole	NOUN
admet-2387	27	20	is	be	AUX
admet-2387	27	21	a	a	DET
admet-2387	27	22	weak	weak	ADJ
admet-2387	27	23	dibasic	dibasic	ADJ
admet-2387	27	24	agent	agent	NOUN
admet-2387	27	25	and	and	CCONJ
admet-2387	27	26	requires	require	VERB
admet-2387	27	27	acidity	acidity	NOUN
admet-2387	27	28	for	for	ADP
admet-2387	27	29	dissolution	dissolution	NOUN
admet-2387	27	30	and	and	CCONJ
admet-2387	27	31	absorption	absorption	NOUN
admet-2387	27	32	.	.	PUNCT
admet-2387	28	1	its	its	PRON
admet-2387	28	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	28	3	in	in	ADP
admet-2387	28	4	humans	human	NOUN
admet-2387	28	5	has	have	AUX
admet-2387	28	6	been	be	AUX
admet-2387	28	7	widely	widely	ADV
admet-2387	28	8	studied	study	VERB
admet-2387	28	9	and	and	CCONJ
admet-2387	28	10	characterized	characterize	VERB
admet-2387	28	11	.	.	PUNCT
admet-2387	29	1	it	it	PRON
admet-2387	29	2	reaches	reach	VERB
admet-2387	29	3	its	its	PRON
admet-2387	29	4	maximum	maximum	ADJ
admet-2387	29	5	plasma	plasma	NOUN
admet-2387	29	6	concentration	concentration	NOUN
admet-2387	29	7	at	at	ADP
admet-2387	29	8	1	1	NUM
admet-2387	29	9	2	2	NUM
admet-2387	29	10	h	h	NOUN
admet-2387	29	11	and	and	CCONJ
admet-2387	29	12	exhibits	exhibit	VERB
admet-2387	29	13	a	a	DET
admet-2387	29	14	biphasic	biphasic	ADJ
admet-2387	29	15	elimination	elimination	NOUN
admet-2387	29	16	of	of	ADP
admet-2387	29	17	2	2	NUM
admet-2387	29	18	h	h	NOUN
admet-2387	29	19	during	during	ADP
admet-2387	29	20	the	the	DET
admet-2387	29	21	first	first	ADJ
admet-2387	29	22	10	10	NUM
admet-2387	29	23	h	h	NOUN
admet-2387	29	24	and	and	CCONJ
admet-2387	29	25	8	8	NUM
admet-2387	29	26	h	h	NOUN
admet-2387	29	27	thereafter	thereafter	ADV
admet-2387	29	28	[	[	X
admet-2387	29	29	4,5	4,5	NUM
admet-2387	29	30	]	]	PUNCT
admet-2387	29	31	.	.	PUNCT
admet-2387	30	1	cyp3a4	cyp3a4	PROPN
admet-2387	30	2	is	be	AUX
admet-2387	30	3	the	the	DET
admet-2387	30	4	major	major	ADJ
admet-2387	30	5	enzyme	enzyme	NOUN
admet-2387	30	6	involved	involve	VERB
admet-2387	30	7	in	in	ADP
admet-2387	30	8	the	the	DET
admet-2387	30	9	metabolism	metabolism	NOUN
admet-2387	30	10	of	of	ADP
admet-2387	30	11	ketoconazole	ketoconazole	NOUN
admet-2387	30	12	.	.	PUNCT
admet-2387	31	1	the	the	DET
admet-2387	31	2	major	major	ADJ
admet-2387	31	3	identified	identify	VERB
admet-2387	31	4	metabolic	metabolic	NOUN
admet-2387	31	5	pathways	pathway	NOUN
admet-2387	31	6	are	be	AUX
admet-2387	31	7	oxidation	oxidation	NOUN
admet-2387	31	8	and	and	CCONJ
admet-2387	31	9	degradation	degradation	NOUN
admet-2387	31	10	of	of	ADP
admet-2387	31	11	the	the	DET
admet-2387	31	12	imidazole	imidazole	NOUN
admet-2387	31	13	and	and	CCONJ
admet-2387	31	14	piperazine	piperazine	NOUN
admet-2387	31	15	rings	ring	NOUN
admet-2387	31	16	by	by	ADP
admet-2387	31	17	hepatic	hepatic	ADJ
admet-2387	31	18	microsomal	microsomal	ADJ
admet-2387	31	19	enzymes	enzyme	NOUN
admet-2387	31	20	.	.	PUNCT
admet-2387	32	1	in	in	ADP
admet-2387	32	2	addition	addition	NOUN
admet-2387	32	3	,	,	PUNCT
admet-2387	32	4	oxidative	oxidative	ADJ
admet-2387	32	5	o	o	NOUN
admet-2387	32	6	-	-	NOUN
admet-2387	32	7	dealkylation	dealkylation	NOUN
admet-2387	32	8	and	and	CCONJ
admet-2387	32	9	aromatic	aromatic	ADJ
admet-2387	32	10	hydroxylation	hydroxylation	NOUN
admet-2387	32	11	do	do	AUX
admet-2387	32	12	occur	occur	VERB
admet-2387	32	13	.	.	PUNCT
admet-2387	33	1	many	many	ADJ
admet-2387	33	2	drug	drug	NOUN
admet-2387	33	3	-	-	PUNCT
admet-2387	33	4	drug	drug	NOUN
admet-2387	33	5	interaction	interaction	NOUN
admet-2387	33	6	studies	study	NOUN
admet-2387	33	7	of	of	ADP
admet-2387	33	8	ketoconazole	ketoconazole	NOUN
admet-2387	33	9	in	in	ADP
admet-2387	33	10	vitro	vitro	X
admet-2387	33	11	and	and	CCONJ
admet-2387	33	12	in	in	ADP
admet-2387	33	13	vivo	vivo	ADJ
admet-2387	33	14	human	human	ADJ
admet-2387	33	15	systems	system	NOUN
admet-2387	33	16	have	have	AUX
admet-2387	33	17	been	be	AUX
admet-2387	33	18	reported	report	VERB
admet-2387	33	19	,	,	PUNCT
admet-2387	33	20	and	and	CCONJ
admet-2387	33	21	such	such	ADJ
admet-2387	33	22	information	information	NOUN
admet-2387	33	23	is	be	AUX
admet-2387	33	24	well	well	ADV
admet-2387	33	25	documented	document	VERB
admet-2387	33	26	[	[	PUNCT
admet-2387	33	27	4,5	4,5	NUM
admet-2387	33	28	]	]	PUNCT
admet-2387	33	29	.	.	PUNCT
admet-2387	34	1	ketoconazole	ketoconazole	PROPN
admet-2387	34	2	has	have	AUX
admet-2387	34	3	also	also	ADV
admet-2387	34	4	been	be	AUX
admet-2387	34	5	recognized	recognize	VERB
admet-2387	34	6	as	as	ADP
admet-2387	34	7	a	a	DET
admet-2387	34	8	specific	specific	ADJ
admet-2387	34	9	cyp3a4/5	cyp3a4/5	NOUN
admet-2387	34	10	inhibitor	inhibitor	NOUN
admet-2387	34	11	and	and	CCONJ
admet-2387	34	12	a	a	DET
admet-2387	34	13	strong	strong	ADJ
admet-2387	34	14	clinical	clinical	ADJ
admet-2387	34	15	cyp3a4	cyp3a4	NOUN
admet-2387	34	16	inhibitor	inhibitor	NOUN
admet-2387	34	17	,	,	PUNCT
admet-2387	34	18	as	as	ADV
admet-2387	34	19	well	well	ADV
admet-2387	34	20	as	as	ADP
admet-2387	34	21	an	an	DET
admet-2387	34	22	inhibitor	inhibitor	NOUN
admet-2387	34	23	of	of	ADP
admet-2387	34	24	p	p	NOUN
admet-2387	34	25	-	-	PUNCT
admet-2387	34	26	gp	gp	NOUN
admet-2387	34	27	,	,	PUNCT
admet-2387	34	28	bcrp	bcrp	ADV
admet-2387	34	29	,	,	PUNCT
admet-2387	34	30	oatps	oatps	NOUN
admet-2387	34	31	,	,	PUNCT
admet-2387	34	32	oat3	oat3	PROPN
admet-2387	34	33	,	,	PUNCT
admet-2387	34	34	oct2	oct2	NOUN
admet-2387	34	35	,	,	PUNCT
admet-2387	34	36	and	and	CCONJ
admet-2387	34	37	mates	mate	NOUN
admet-2387	34	38	transporters	transporter	NOUN
admet-2387	34	39	,	,	PUNCT
admet-2387	34	40	clinical	clinical	ADJ
admet-2387	34	41	p	p	NOUN
admet-2387	34	42	-	-	PUNCT
admet-2387	34	43	gp	gp	NOUN
admet-2387	34	44	inhibitor	inhibitor	NOUN
admet-2387	34	45	for	for	ADP
admet-2387	34	46	drug	drug	NOUN
admet-2387	34	47	-	-	PUNCT
admet-2387	34	48	drug	drug	NOUN
admet-2387	34	49	interaction	interaction	NOUN
admet-2387	34	50	studies	study	NOUN
admet-2387	34	51	recommended	recommend	VERB
admet-2387	34	52	by	by	ADP
admet-2387	34	53	regulatory	regulatory	ADJ
admet-2387	34	54	agencies	agency	NOUN
admet-2387	34	55	[	[	X
admet-2387	34	56	6	6	NUM
admet-2387	34	57	]	]	PUNCT
admet-2387	34	58	.	.	PUNCT
admet-2387	35	1	orally	orally	ADV
admet-2387	35	2	administered	administer	VERB
admet-2387	35	3	ketoconazole	ketoconazole	PROPN
admet-2387	35	4	is	be	AUX
admet-2387	35	5	limited	limit	VERB
admet-2387	35	6	in	in	ADP
admet-2387	35	7	clinical	clinical	ADJ
admet-2387	35	8	use	use	NOUN
admet-2387	35	9	due	due	ADP
admet-2387	35	10	to	to	ADP
admet-2387	35	11	metabolism	metabolism	NOUN
admet-2387	35	12	-	-	PUNCT
admet-2387	35	13	related	relate	VERB
admet-2387	35	14	hepatotoxicity	hepatotoxicity	NOUN
admet-2387	35	15	[	[	X
admet-2387	35	16	7	7	NUM
admet-2387	35	17	-	-	SYM
admet-2387	35	18	10	10	NUM
admet-2387	35	19	]	]	PUNCT
admet-2387	35	20	.	.	PUNCT
admet-2387	36	1	n	n	CCONJ
admet-2387	36	2	-	-	PUNCT
admet-2387	36	3	deacetyl	deacetyl	NOUN
admet-2387	36	4	ketoconazole	ketoconazole	NOUN
admet-2387	36	5	(	(	PUNCT
admet-2387	36	6	dak	dak	PROPN
admet-2387	36	7	)	)	PUNCT
admet-2387	36	8	,	,	PUNCT
admet-2387	36	9	as	as	ADP
admet-2387	36	10	a	a	DET
admet-2387	36	11	primary	primary	ADJ
admet-2387	36	12	metabolite	metabolite	NOUN
admet-2387	36	13	of	of	ADP
admet-2387	36	14	ketoconazole	ketoconazole	NOUN
admet-2387	36	15	,	,	PUNCT
admet-2387	36	16	is	be	AUX
admet-2387	36	17	believed	believe	VERB
admet-2387	36	18	to	to	PART
admet-2387	36	19	undergo	undergo	VERB
admet-2387	36	20	metabolism	metabolism	NOUN
admet-2387	36	21	through	through	ADP
admet-2387	36	22	flavin	flavin	NOUN
admet-2387	36	23	-	-	PUNCT
admet-2387	36	24	containing	contain	VERB
admet-2387	36	25	monooxygenase	monooxygenase	NOUN
admet-2387	36	26	(	(	PUNCT
admet-2387	36	27	fmo	fmo	NOUN
admet-2387	36	28	)	)	PUNCT
admet-2387	36	29	and	and	CCONJ
admet-2387	36	30	may	may	AUX
admet-2387	36	31	be	be	AUX
admet-2387	36	32	transformed	transform	VERB
admet-2387	36	33	into	into	ADP
admet-2387	36	34	a	a	DET
admet-2387	36	35	potentially	potentially	ADV
admet-2387	36	36	toxic	toxic	ADJ
admet-2387	36	37	dialdehyde	dialdehyde	NOUN
admet-2387	37	1	[	[	PUNCT
admet-2387	37	2	11	11	NUM
admet-2387	37	3	-	-	SYM
admet-2387	37	4	14	14	NUM
admet-2387	37	5	]	]	PUNCT
admet-2387	37	6	.	.	PUNCT
admet-2387	38	1	rodriguez	rodriguez	NOUN
admet-2387	38	2	et	et	PROPN
admet-2387	38	3	al	al	PROPN
admet-2387	38	4	.	.	PUNCT
admet-2387	39	1	[	[	X
admet-2387	39	2	11	11	NUM
admet-2387	39	3	]	]	PUNCT
admet-2387	39	4	studied	study	VERB
admet-2387	39	5	the	the	DET
admet-2387	39	6	toxicity	toxicity	NOUN
admet-2387	39	7	of	of	ADP
admet-2387	39	8	dak	dak	PROPN
admet-2387	39	9	and	and	CCONJ
admet-2387	39	10	demonstrated	demonstrate	VERB
admet-2387	39	11	that	that	SCONJ
admet-2387	39	12	it	it	PRON
admet-2387	39	13	was	be	AUX
admet-2387	39	14	more	more	ADV
admet-2387	39	15	metabolically	metabolically	ADV
admet-2387	39	16	cytotoxic	cytotoxic	ADJ
admet-2387	39	17	than	than	ADP
admet-2387	39	18	ketoconazole	ketoconazole	NOUN
admet-2387	39	19	.	.	PUNCT
admet-2387	40	1	afterwards	afterwards	ADV
admet-2387	40	2	,	,	PUNCT
admet-2387	40	3	haegler	haegler	NOUN
admet-2387	40	4	et	et	NOUN
admet-2387	40	5	al	al	PROPN
admet-2387	40	6	.	.	PUNCT
admet-2387	41	1	[	[	X
admet-2387	41	2	12	12	NUM
admet-2387	41	3	]	]	PUNCT
admet-2387	41	4	studied	study	VERB
admet-2387	41	5	the	the	DET
admet-2387	41	6	mitochondrial	mitochondrial	ADJ
admet-2387	41	7	toxic	toxic	ADJ
admet-2387	41	8	effects	effect	NOUN
admet-2387	41	9	of	of	ADP
admet-2387	41	10	ketoconazole	ketoconazole	NOUN
admet-2387	41	11	at	at	ADP
admet-2387	41	12	concentrations	concentration	NOUN
admet-2387	41	13	easily	easily	ADV
admet-2387	41	14	reached	reach	VERB
admet-2387	41	15	in	in	ADP
admet-2387	41	16	vivo	vivo	NOUN
admet-2387	41	17	.	.	PUNCT
admet-2387	42	1	they	they	PRON
admet-2387	42	2	found	find	VERB
admet-2387	42	3	that	that	SCONJ
admet-2387	42	4	cytotoxicity	cytotoxicity	NOUN
admet-2387	42	5	and	and	CCONJ
admet-2387	42	6	adenosine	adenosine	NOUN
admet-2387	42	7	triphosphate	triphosphate	NOUN
admet-2387	42	8	(	(	PUNCT
admet-2387	42	9	atp	atp	NOUN
admet-2387	42	10	)	)	PUNCT
admet-2387	42	11	depletion	depletion	NOUN
admet-2387	42	12	were	be	AUX
admet-2387	42	13	more	more	ADV
admet-2387	42	14	pronounced	pronounced	ADJ
admet-2387	42	15	in	in	ADP
admet-2387	42	16	cells	cell	NOUN
admet-2387	42	17	with	with	ADP
admet-2387	42	18	mitochondrial	mitochondrial	ADJ
admet-2387	42	19	damage	damage	NOUN
admet-2387	42	20	.	.	PUNCT
admet-2387	43	1	in	in	ADP
admet-2387	43	2	july	july	PROPN
admet-2387	43	3	,	,	PUNCT
admet-2387	43	4	2013	2013	NUM
admet-2387	43	5	,	,	PUNCT
admet-2387	43	6	the	the	DET
admet-2387	43	7	us	us	PROPN
admet-2387	43	8	fda	fda	PROPN
admet-2387	43	9	released	release	VERB
admet-2387	43	10	a	a	DET
admet-2387	43	11	safety	safety	NOUN
admet-2387	43	12	announcement	announcement	NOUN
admet-2387	43	13	regarding	regard	VERB
admet-2387	43	14	the	the	DET
admet-2387	43	15	use	use	NOUN
admet-2387	43	16	of	of	ADP
admet-2387	43	17	oral	oral	ADJ
admet-2387	43	18	ketoconazole	ketoconazole	NOUN
admet-2387	43	19	tablets	tablet	NOUN
admet-2387	43	20	and	and	CCONJ
admet-2387	43	21	their	their	PRON
admet-2387	43	22	potential	potential	ADJ
admet-2387	43	23	adverse	adverse	ADJ
admet-2387	43	24	drug	drug	NOUN
admet-2387	43	25	reactions	reaction	NOUN
admet-2387	43	26	.	.	PUNCT
admet-2387	44	1	it	it	PRON
admet-2387	44	2	was	be	AUX
admet-2387	44	3	advised	advise	VERB
admet-2387	44	4	that	that	SCONJ
admet-2387	44	5	ketoconazole	ketoconazole	NOUN
admet-2387	44	6	should	should	AUX
admet-2387	44	7	not	not	PART
admet-2387	44	8	be	be	AUX
admet-2387	44	9	used	use	VERB
admet-2387	44	10	as	as	ADP
admet-2387	44	11	a	a	DET
admet-2387	44	12	first	first	ADJ
admet-2387	44	13	-	-	PUNCT
admet-2387	44	14	line	line	NOUN
admet-2387	44	15	treatment	treatment	NOUN
admet-2387	44	16	for	for	ADP
admet-2387	44	17	fungal	fungal	ADJ
admet-2387	44	18	infections	infection	NOUN
admet-2387	44	19	due	due	ADP
admet-2387	44	20	to	to	ADP
admet-2387	44	21	the	the	DET
admet-2387	44	22	risk	risk	NOUN
admet-2387	44	23	of	of	ADP
admet-2387	44	24	potentially	potentially	ADV
admet-2387	44	25	serious	serious	ADJ
admet-2387	44	26	drug	drug	NOUN
admet-2387	44	27	-	-	PUNCT
admet-2387	44	28	drug	drug	NOUN
admet-2387	44	29	interactions	interaction	NOUN
admet-2387	44	30	[	[	X
admet-2387	44	31	15	15	NUM
admet-2387	44	32	-	-	SYM
admet-2387	44	33	17	17	NUM
admet-2387	44	34	]	]	PUNCT
admet-2387	44	35	.	.	PUNCT
admet-2387	45	1	the	the	DET
admet-2387	45	2	european	european	PROPN
admet-2387	45	3	medicines	medicine	NOUN
admet-2387	45	4	agency	agency	NOUN
admet-2387	45	5	had	have	AUX
admet-2387	45	6	also	also	ADV
admet-2387	45	7	proposed	propose	VERB
admet-2387	45	8	limiting	limit	VERB
admet-2387	45	9	the	the	DET
admet-2387	45	10	use	use	NOUN
admet-2387	45	11	of	of	ADP
admet-2387	45	12	oral	oral	ADJ
admet-2387	45	13	ketoconazole	ketoconazole	NOUN
admet-2387	45	14	in	in	ADP
admet-2387	45	15	fungal	fungal	ADJ
admet-2387	45	16	infections	infection	NOUN
admet-2387	45	17	due	due	ADP
admet-2387	45	18	to	to	ADP
admet-2387	45	19	the	the	DET
admet-2387	45	20	same	same	ADJ
admet-2387	45	21	risk	risk	NOUN
admet-2387	45	22	[	[	X
admet-2387	45	23	18,19	18,19	NUM
admet-2387	45	24	]	]	PUNCT
admet-2387	45	25	.	.	PUNCT
admet-2387	46	1	unlike	unlike	ADP
admet-2387	46	2	oral	oral	ADJ
admet-2387	46	3	administration	administration	NOUN
admet-2387	46	4	,	,	PUNCT
admet-2387	46	5	local	local	ADJ
admet-2387	46	6	drug	drug	NOUN
admet-2387	46	7	administration	administration	NOUN
admet-2387	46	8	,	,	PUNCT
admet-2387	46	9	such	such	ADJ
admet-2387	46	10	as	as	ADP
admet-2387	46	11	intramuscular	intramuscular	ADJ
admet-2387	46	12	,	,	PUNCT
admet-2387	46	13	intraperitoneal	intraperitoneal	ADJ
admet-2387	46	14	,	,	PUNCT
admet-2387	46	15	subcutaneous	subcutaneous	ADJ
admet-2387	46	16	,	,	PUNCT
admet-2387	46	17	transdermal	transdermal	ADJ
admet-2387	46	18	,	,	PUNCT
admet-2387	46	19	and	and	CCONJ
admet-2387	46	20	topical	topical	ADJ
admet-2387	46	21	ocular	ocular	ADJ
admet-2387	46	22	administration	administration	NOUN
admet-2387	46	23	,	,	PUNCT
admet-2387	46	24	can	can	AUX
admet-2387	46	25	be	be	AUX
admet-2387	46	26	an	an	DET
admet-2387	46	27	alternative	alternative	ADJ
admet-2387	46	28	approach	approach	NOUN
admet-2387	46	29	to	to	PART
admet-2387	46	30	avoid	avoid	VERB
admet-2387	46	31	firstpass	firstpass	ADJ
admet-2387	46	32	intestinal	intestinal	ADJ
admet-2387	46	33	and	and	CCONJ
admet-2387	46	34	hepatic	hepatic	ADJ
admet-2387	46	35	metabolism	metabolism	NOUN
admet-2387	46	36	and	and	CCONJ
admet-2387	46	37	associated	associate	VERB
admet-2387	46	38	drug	drug	NOUN
admet-2387	46	39	-	-	PUNCT
admet-2387	46	40	drug	drug	NOUN
admet-2387	46	41	interactions	interaction	NOUN
admet-2387	46	42	and	and	CCONJ
admet-2387	46	43	achieve	achieve	VERB
admet-2387	46	44	higher	high	ADJ
admet-2387	46	45	exposure	exposure	NOUN
admet-2387	46	46	levels	level	NOUN
admet-2387	46	47	in	in	ADP
admet-2387	46	48	target	target	NOUN
admet-2387	46	49	organs	organ	NOUN
admet-2387	46	50	due	due	ADJ
admet-2387	46	51	to	to	ADP
admet-2387	46	52	a	a	DET
admet-2387	46	53	lower	low	ADJ
admet-2387	46	54	metabolic	metabolic	NOUN
admet-2387	46	55	loss	loss	NOUN
admet-2387	46	56	of	of	ADP
admet-2387	46	57	the	the	DET
admet-2387	46	58	drug	drug	NOUN
admet-2387	46	59	.	.	PUNCT
admet-2387	47	1	ocular	ocular	ADJ
admet-2387	47	2	drug	drug	NOUN
admet-2387	47	3	delivery	delivery	NOUN
admet-2387	47	4	has	have	AUX
admet-2387	47	5	been	be	AUX
admet-2387	47	6	an	an	DET
admet-2387	47	7	active	active	ADJ
admet-2387	47	8	area	area	NOUN
admet-2387	47	9	in	in	ADP
admet-2387	47	10	the	the	DET
admet-2387	47	11	use	use	NOUN
admet-2387	47	12	of	of	ADP
admet-2387	47	13	old	old	ADJ
admet-2387	47	14	drugs	drug	NOUN
admet-2387	47	15	and	and	CCONJ
admet-2387	47	16	new	new	ADJ
admet-2387	47	17	ophthalmic	ophthalmic	ADJ
admet-2387	47	18	drug	drug	NOUN
admet-2387	47	19	discovery	discovery	NOUN
admet-2387	47	20	and	and	CCONJ
admet-2387	47	21	development	development	NOUN
admet-2387	47	22	[	[	X
admet-2387	47	23	20	20	NUM
admet-2387	47	24	-	-	SYM
admet-2387	47	25	23	23	NUM
admet-2387	47	26	]	]	PUNCT
admet-2387	47	27	.	.	PUNCT
admet-2387	48	1	fundamental	fundamental	ADJ
admet-2387	48	2	drugmetabolizing	drugmetabolizing	NOUN
admet-2387	48	3	enzymes	enzyme	NOUN
admet-2387	48	4	,	,	PUNCT
admet-2387	48	5	uptake	uptake	ADJ
admet-2387	48	6	,	,	PUNCT
admet-2387	48	7	and	and	CCONJ
admet-2387	48	8	efflux	efflux	VERB
admet-2387	48	9	transport	transport	NOUN
admet-2387	48	10	information	information	NOUN
admet-2387	48	11	in	in	ADP
admet-2387	48	12	different	different	ADJ
admet-2387	48	13	locations	location	NOUN
admet-2387	48	14	of	of	ADP
admet-2387	48	15	the	the	DET
admet-2387	48	16	eyes	eye	NOUN
admet-2387	48	17	in	in	ADP
admet-2387	48	18	animals	animal	NOUN
admet-2387	48	19	and	and	CCONJ
admet-2387	48	20	humans	human	NOUN
admet-2387	48	21	(	(	PUNCT
admet-2387	48	22	cornea	cornea	NOUN
admet-2387	48	23	,	,	PUNCT
admet-2387	48	24	lens	len	NOUN
admet-2387	48	25	,	,	PUNCT
admet-2387	48	26	iris	iris	NOUN
admet-2387	48	27	,	,	PUNCT
admet-2387	48	28	retina	retina	NOUN
admet-2387	48	29	,	,	PUNCT
admet-2387	48	30	vitreous	vitreous	ADJ
admet-2387	48	31	humour	humour	NOUN
admet-2387	48	32	,	,	PUNCT
admet-2387	48	33	etc	etc	X
admet-2387	48	34	.	.	X
admet-2387	48	35	)	)	PUNCT
admet-2387	48	36	are	be	AUX
admet-2387	48	37	very	very	ADV
admet-2387	48	38	limited	limited	ADJ
admet-2387	48	39	.	.	PUNCT
admet-2387	49	1	the	the	DET
admet-2387	49	2	eye	eye	NOUN
admet-2387	49	3	is	be	AUX
admet-2387	49	4	a	a	DET
admet-2387	49	5	complex	complex	ADJ
admet-2387	49	6	organ	organ	NOUN
admet-2387	49	7	with	with	ADP
admet-2387	49	8	protective	protective	ADJ
admet-2387	49	9	anatomy	anatomy	NOUN
admet-2387	49	10	and	and	CCONJ
admet-2387	49	11	physiology	physiology	NOUN
admet-2387	49	12	.	.	PUNCT
admet-2387	50	1	understanding	understand	VERB
admet-2387	50	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	50	3	and	and	CCONJ
admet-2387	50	4	drug	drug	NOUN
admet-2387	50	5	metabolism	metabolism	NOUN
admet-2387	50	6	in	in	ADP
admet-2387	50	7	ocular	ocular	ADJ
admet-2387	50	8	tissues	tissue	NOUN
admet-2387	50	9	is	be	AUX
admet-2387	50	10	a	a	DET
admet-2387	50	11	major	major	ADJ
admet-2387	50	12	challenge	challenge	NOUN
admet-2387	50	13	because	because	SCONJ
admet-2387	50	14	of	of	ADP
admet-2387	50	15	the	the	DET
admet-2387	50	16	complex	complex	ADJ
admet-2387	50	17	anatomy	anatomy	NOUN
admet-2387	50	18	and	and	CCONJ
admet-2387	50	19	dynamic	dynamic	ADJ
admet-2387	50	20	physiological	physiological	ADJ
admet-2387	50	21	barrier	barrier	NOUN
admet-2387	50	22	of	of	ADP
admet-2387	50	23	the	the	DET
admet-2387	50	24	eye	eye	NOUN
admet-2387	50	25	.	.	PUNCT
admet-2387	51	1	ocular	ocular	ADJ
admet-2387	51	2	drug	drug	NOUN
admet-2387	51	3	metabolism	metabolism	NOUN
admet-2387	51	4	in	in	ADP
admet-2387	51	5	the	the	DET
admet-2387	51	6	eye	eye	NOUN
admet-2387	51	7	is	be	AUX
admet-2387	51	8	crucial	crucial	ADJ
admet-2387	51	9	for	for	ADP
admet-2387	51	10	ocular	ocular	ADJ
admet-2387	51	11	therapeutics	therapeutic	NOUN
admet-2387	51	12	to	to	PART
admet-2387	51	13	facilitate	facilitate	VERB
admet-2387	51	14	the	the	DET
admet-2387	51	15	risk	risk	NOUN
admet-2387	51	16	assessment	assessment	NOUN
admet-2387	51	17	and	and	CCONJ
admet-2387	51	18	the	the	DET
admet-2387	51	19	development	development	NOUN
admet-2387	51	20	of	of	ADP
admet-2387	51	21	potential	potential	ADJ
admet-2387	51	22	drug	drug	NOUN
admet-2387	51	23	candidates	candidate	NOUN
admet-2387	51	24	in	in	ADP
admet-2387	51	25	the	the	DET
admet-2387	51	26	clinical	clinical	ADJ
admet-2387	51	27	stage	stage	NOUN
admet-2387	51	28	.	.	PUNCT
admet-2387	52	1	in	in	ADP
admet-2387	52	2	the	the	DET
admet-2387	52	3	discovery	discovery	NOUN
admet-2387	52	4	stage	stage	NOUN
admet-2387	52	5	,	,	PUNCT
admet-2387	52	6	rabbits	rabbit	NOUN
admet-2387	52	7	and	and	CCONJ
admet-2387	52	8	other	other	ADJ
admet-2387	52	9	less	less	ADV
admet-2387	52	10	common	common	ADJ
admet-2387	52	11	species	specie	NOUN
admet-2387	52	12	,	,	PUNCT
admet-2387	52	13	such	such	ADJ
admet-2387	52	14	as	as	ADP
admet-2387	52	15	dogs	dog	NOUN
admet-2387	52	16	,	,	PUNCT
admet-2387	52	17	monkeys	monkey	NOUN
admet-2387	52	18	,	,	PUNCT
admet-2387	52	19	and	and	CCONJ
admet-2387	52	20	rats	rat	NOUN
admet-2387	52	21	,	,	PUNCT
admet-2387	52	22	are	be	AUX
admet-2387	52	23	also	also	ADV
admet-2387	52	24	used	use	VERB
admet-2387	52	25	to	to	PART
admet-2387	52	26	study	study	VERB
admet-2387	52	27	ocular	ocular	ADJ
admet-2387	52	28	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	52	29	and	and	CCONJ
admet-2387	52	30	drug	drug	NOUN
admet-2387	52	31	metabolism	metabolism	NOUN
admet-2387	53	1	[	[	X
admet-2387	53	2	24	24	NUM
admet-2387	53	3	-	-	SYM
admet-2387	53	4	28	28	NUM
admet-2387	53	5	]	]	PUNCT
admet-2387	53	6	.	.	PUNCT
admet-2387	54	1	as	as	SCONJ
admet-2387	54	2	shown	show	VERB
admet-2387	54	3	in	in	ADP
admet-2387	54	4	a	a	DET
admet-2387	54	5	recent	recent	ADJ
admet-2387	54	6	mini	mini	NOUN
admet-2387	54	7	-	-	NOUN
admet-2387	54	8	review	review	NOUN
admet-2387	54	9	,	,	PUNCT
admet-2387	54	10	twenty	twenty	NUM
admet-2387	54	11	-	-	PUNCT
admet-2387	54	12	six	six	NUM
admet-2387	54	13	enzymes	enzyme	NOUN
admet-2387	54	14	,	,	PUNCT
admet-2387	54	15	including	include	VERB
admet-2387	54	16	eleven	eleven	NUM
admet-2387	54	17	human	human	ADJ
admet-2387	54	18	cyp	cyp	ADJ
admet-2387	54	19	enzymes	enzyme	NOUN
admet-2387	54	20	(	(	PUNCT
admet-2387	54	21	cyp1a2	cyp1a2	PROPN
admet-2387	54	22	,	,	PUNCT
admet-2387	54	23	cyp1b1	cyp1b1	ADJ
admet-2387	54	24	,	,	PUNCT
admet-2387	54	25	cyp2a6	cyp2a6	NOUN
admet-2387	54	26	,	,	PUNCT
admet-2387	54	27	cyp2b6	cyp2b6	NOUN
admet-2387	54	28	,	,	PUNCT
admet-2387	54	29	cyp2c8	cyp2c8	ADV
admet-2387	54	30	,	,	PUNCT
admet-2387	54	31	cyp2c9	cyp2c9	NOUN
admet-2387	54	32	,	,	PUNCT
admet-2387	54	33	cyp2c19	cyp2c19	PROPN
admet-2387	54	34	,	,	PUNCT
admet-2387	54	35	cyp2e1	cyp2e1	ADJ
admet-2387	54	36	,	,	PUNCT
admet-2387	54	37	cyp2d6	cyp2d6	NOUN
admet-2387	54	38	,	,	PUNCT
admet-2387	54	39	cyp3a4	cyp3a4	NOUN
admet-2387	54	40	,	,	PUNCT
admet-2387	54	41	cyp3a5	cyp3a5	NOUN
admet-2387	54	42	)	)	PUNCT
admet-2387	54	43	and	and	CCONJ
admet-2387	54	44	other	other	ADJ
admet-2387	54	45	phase	phase	NOUN
admet-2387	54	46	i	i	PRON
admet-2387	54	47	/	/	SYM
admet-2387	54	48	ii	ii	NOUN
admet-2387	54	49	enzymes	enzyme	NOUN
admet-2387	54	50	in	in	ADP
admet-2387	54	51	cornea	cornea	PROPN
admet-2387	54	52	,	,	PUNCT
admet-2387	54	53	lens	len	NOUN
admet-2387	54	54	,	,	PUNCT
admet-2387	54	55	iris	iris	NOUN
admet-2387	54	56	,	,	PUNCT
admet-2387	54	57	ciliary	ciliary	ADJ
admet-2387	54	58	body	body	NOUN
admet-2387	54	59	,	,	PUNCT
admet-2387	54	60	retina	retina	NOUN
admet-2387	54	61	,	,	PUNCT
admet-2387	54	62	choroid	choroid	ADJ
admet-2387	54	63	,	,	PUNCT
admet-2387	54	64	retinal	retinal	ADJ
admet-2387	54	65	pigment	pigment	NOUN
admet-2387	54	66	epithelium	epithelium	NOUN
admet-2387	54	67	,	,	PUNCT
admet-2387	54	68	optic	optic	ADJ
admet-2387	54	69	nerve	nerve	NOUN
admet-2387	54	70	and	and	CCONJ
admet-2387	54	71	sclera	sclera	NOUN
admet-2387	54	72	,	,	PUNCT
admet-2387	54	73	and	and	CCONJ
admet-2387	54	74	38	38	NUM
admet-2387	54	75	uptake	uptake	ADJ
admet-2387	54	76	and	and	CCONJ
admet-2387	54	77	efflux	efflux	VERB
admet-2387	54	78	transporters	transporter	NOUN
admet-2387	54	79	including	include	VERB
admet-2387	54	80	mate1	mate1	NOUN
admet-2387	54	81	-	-	PUNCT
admet-2387	54	82	2	2	NUM
admet-2387	54	83	,	,	PUNCT
admet-2387	54	84	pept1	pept1	NOUN
admet-2387	54	85	-	-	PUNCT
admet-2387	54	86	2	2	NUM
admet-2387	54	87	,	,	PUNCT
admet-2387	54	88	p	p	NOUN
admet-2387	54	89	-	-	PUNCT
admet-2387	54	90	gp	gp	NOUN
admet-2387	54	91	,	,	PUNCT
admet-2387	54	92	bcrp	bcrp	ADV
admet-2387	54	93	,	,	PUNCT
admet-2387	54	94	and	and	CCONJ
admet-2387	54	95	mrp1	mrp1	NOUN
admet-2387	54	96	-	-	PUNCT
admet-2387	54	97	6	6	NUM
admet-2387	54	98	in	in	ADP
admet-2387	54	99	cornea	cornea	PROPN
admet-2387	54	100	,	,	PUNCT
admet-2387	54	101	lens	len	NOUN
admet-2387	54	102	,	,	PUNCT
admet-2387	54	103	iris	iris	NOUN
admet-2387	54	104	,	,	PUNCT
admet-2387	54	105	ciliary	ciliary	ADJ
admet-2387	54	106	body	body	NOUN
admet-2387	54	107	,	,	PUNCT
admet-2387	54	108	retina	retina	NOUN
admet-2387	54	109	and	and	CCONJ
admet-2387	54	110	choroid	choroid	AUX
admet-2387	54	111	,	,	PUNCT
admet-2387	54	112	were	be	AUX
admet-2387	54	113	reported	report	VERB
admet-2387	54	114	[	[	X
admet-2387	54	115	29	29	NUM
admet-2387	54	116	]	]	PUNCT
admet-2387	54	117	.	.	PUNCT
admet-2387	55	1	although	although	SCONJ
admet-2387	55	2	the	the	DET
admet-2387	55	3	metabolism	metabolism	NOUN
admet-2387	55	4	of	of	ADP
admet-2387	55	5	ketoconazole	ketoconazole	NOUN
admet-2387	55	6	after	after	ADP
admet-2387	55	7	oral	oral	ADJ
admet-2387	55	8	administration	administration	NOUN
admet-2387	55	9	in	in	ADP
admet-2387	55	10	humans	human	NOUN
admet-2387	55	11	is	be	AUX
admet-2387	55	12	well	well	ADV
admet-2387	55	13	studied	study	VERB
admet-2387	55	14	,	,	PUNCT
admet-2387	55	15	it	it	PRON
admet-2387	55	16	is	be	AUX
admet-2387	55	17	not	not	PART
admet-2387	55	18	well	well	ADV
admet-2387	55	19	explored	explore	VERB
admet-2387	55	20	in	in	ADP
admet-2387	55	21	the	the	DET
admet-2387	55	22	eye	eye	NOUN
admet-2387	55	23	in	in	ADP
admet-2387	55	24	any	any	DET
admet-2387	55	25	preclinical	preclinical	ADJ
admet-2387	55	26	species	specie	NOUN
admet-2387	55	27	or	or	CCONJ
admet-2387	55	28	humans	human	NOUN
admet-2387	55	29	.	.	PUNCT
admet-2387	56	1	in	in	ADP
admet-2387	56	2	rats	rat	NOUN
admet-2387	56	3	,	,	PUNCT
admet-2387	56	4	ketoconazole	ketoconazole	PROPN
admet-2387	56	5	has	have	AUX
admet-2387	56	6	been	be	AUX
admet-2387	56	7	well	well	ADV
admet-2387	56	8	studied	study	VERB
admet-2387	56	9	as	as	ADP
admet-2387	56	10	a	a	DET
admet-2387	56	11	substrate	substrate	NOUN
admet-2387	56	12	in	in	ADP
admet-2387	56	13	vitro	vitro	X
admet-2387	56	14	system	system	NOUN
admet-2387	57	1	[	[	X
admet-2387	57	2	30,31	30,31	NUM
admet-2387	57	3	]	]	PUNCT
admet-2387	57	4	and	and	CCONJ
admet-2387	57	5	in	in	ADP
admet-2387	57	6	vivo	vivo	ADJ
admet-2387	57	7	systems	system	NOUN
admet-2387	57	8	[	[	X
admet-2387	57	9	30	30	NUM
admet-2387	57	10	-	-	SYM
admet-2387	57	11	32	32	NUM
admet-2387	57	12	]	]	PUNCT
admet-2387	57	13	or	or	CCONJ
admet-2387	57	14	as	as	ADP
admet-2387	57	15	a	a	DET
admet-2387	57	16	rat	rat	NOUN
admet-2387	57	17	cyp3a	cyp3a	NOUN
admet-2387	57	18	inhibitor	inhibitor	NOUN
admet-2387	57	19	in	in	ADP
admet-2387	57	20	vitro	vitro	X
admet-2387	57	21	sys	sys	PROPN
admet-2387	57	22	tems	tem	NOUN
admet-2387	57	23	[	[	X
admet-2387	57	24	33	33	NUM
admet-2387	57	25	-	-	SYM
admet-2387	57	26	35	35	NUM
admet-2387	57	27	]	]	PUNCT
admet-2387	57	28	and	and	CCONJ
admet-2387	57	29	in	in	ADP
admet-2387	57	30	vivo	vivo	ADJ
admet-2387	57	31	systems	system	NOUN
admet-2387	57	32	[	[	X
admet-2387	57	33	36	36	NUM
admet-2387	57	34	-	-	SYM
admet-2387	57	35	57	57	NUM
admet-2387	57	36	]	]	PUNCT
admet-2387	57	37	.	.	PUNCT
admet-2387	58	1	cirello	cirello	INTJ
admet-2387	58	2	et	et	PROPN
admet-2387	58	3	al	al	PROPN
admet-2387	58	4	.	.	PUNCT
admet-2387	59	1	[	[	X
admet-2387	59	2	58	58	NUM
admet-2387	59	3	]	]	PUNCT
admet-2387	59	4	reported	report	VERB
admet-2387	59	5	that	that	SCONJ
admet-2387	59	6	in	in	ADP
admet-2387	59	7	rat	rat	NOUN
admet-2387	59	8	,	,	PUNCT
admet-2387	59	9	rabbit	rabbit	NOUN
admet-2387	59	10	,	,	PUNCT
admet-2387	59	11	and	and	CCONJ
admet-2387	59	12	human	human	ADJ
admet-2387	59	13	ocular	ocular	ADJ
admet-2387	59	14	and	and	CCONJ
admet-2387	59	15	liver	liver	NOUN
admet-2387	59	16	s9	s9	NOUN
admet-2387	59	17	fractions	fraction	NOUN
admet-2387	59	18	,	,	PUNCT
admet-2387	59	19	eleven	eleven	NUM
admet-2387	59	20	metabolites	metabolite	NOUN
admet-2387	59	21	were	be	AUX
admet-2387	59	22	identified	identify	VERB
admet-2387	59	23	,	,	PUNCT
admet-2387	59	24	six	six	NUM
admet-2387	59	25	metabolites	metabolite	NOUN
admet-2387	59	26	were	be	AUX
admet-2387	59	27	found	find	VERB
admet-2387	59	28	in	in	ADP
admet-2387	59	29	rat	rat	NOUN
admet-2387	59	30	ocular	ocular	NOUN
admet-2387	59	31	,	,	PUNCT
admet-2387	59	32	whereas	whereas	SCONJ
admet-2387	59	33	eight	eight	NUM
admet-2387	59	34	were	be	AUX
admet-2387	59	35	present	present	ADJ
admet-2387	59	36	in	in	ADP
admet-2387	59	37	rabbit	rabbit	NOUN
admet-2387	59	38	and	and	CCONJ
admet-2387	59	39	human	human	ADJ
admet-2387	59	40	ocular	ocular	ADJ
admet-2387	59	41	s9	s9	NOUN
admet-2387	59	42	fractions	fraction	NOUN
admet-2387	59	43	.	.	PUNCT
admet-2387	60	1	three	three	NUM
admet-2387	60	2	more	more	ADJ
admet-2387	60	3	metabolites	metabolite	NOUN
admet-2387	60	4	were	be	AUX
admet-2387	60	5	found	find	VERB
admet-2387	60	6	in	in	ADP
admet-2387	60	7	rat	rat	NOUN
admet-2387	60	8	liver	liver	NOUN
admet-2387	60	9	than	than	ADP
admet-2387	60	10	admet	admet	PROPN
admet-2387	60	11	&	&	CCONJ
admet-2387	60	12	dmpk	dmpk	PROPN
admet-2387	60	13	12(6	12(6	NUM
admet-2387	60	14	)	)	PUNCT
admet-2387	60	15	(	(	PUNCT
admet-2387	60	16	2024	2024	NUM
admet-2387	60	17	)	)	PUNCT
admet-2387	60	18	943	943	NUM
admet-2387	60	19	-	-	SYM
admet-2387	60	20	955	955	NUM
admet-2387	60	21	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	60	22	and	and	CCONJ
admet-2387	60	23	metabolism	metabolism	NOUN
admet-2387	60	24	of	of	ADP
admet-2387	60	25	ketoconazole	ketoconazole	PROPN
admet-2387	60	26	doi	doi	PROPN
admet-2387	60	27	:	:	PUNCT
admet-2387	60	28	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	60	29	945	945	NUM
admet-2387	60	30	in	in	ADP
admet-2387	60	31	rat	rat	NOUN
admet-2387	60	32	ocular	ocular	ADJ
admet-2387	60	33	s9	s9	NOUN
admet-2387	60	34	fractions	fraction	NOUN
admet-2387	60	35	.	.	PUNCT
admet-2387	61	1	metabolic	metabolic	NOUN
admet-2387	61	2	pathways	pathway	NOUN
admet-2387	61	3	in	in	ADP
admet-2387	61	4	rabbit	rabbit	NOUN
admet-2387	61	5	and	and	CCONJ
admet-2387	61	6	human	human	ADJ
admet-2387	61	7	ocular	ocular	ADJ
admet-2387	61	8	fractions	fraction	NOUN
admet-2387	61	9	suggested	suggest	VERB
admet-2387	61	10	the	the	DET
admet-2387	61	11	formation	formation	NOUN
admet-2387	61	12	of	of	ADP
admet-2387	61	13	reactive	reactive	ADJ
admet-2387	61	14	intermediates	intermediate	NOUN
admet-2387	61	15	in	in	ADP
admet-2387	61	16	rabbit	rabbit	NOUN
admet-2387	61	17	and	and	CCONJ
admet-2387	61	18	human	human	ADJ
admet-2387	61	19	liver	liver	NOUN
admet-2387	61	20	,	,	PUNCT
admet-2387	61	21	and	and	CCONJ
admet-2387	61	22	ocular	ocular	ADJ
admet-2387	61	23	s9	s9	NOUN
admet-2387	61	24	incubations	incubation	NOUN
admet-2387	61	25	.	.	PUNCT
admet-2387	62	1	bioactivation	bioactivation	NOUN
admet-2387	62	2	was	be	AUX
admet-2387	62	3	found	find	VERB
admet-2387	62	4	to	to	PART
admet-2387	62	5	occur	occur	VERB
admet-2387	62	6	via	via	ADP
admet-2387	62	7	iminium	iminium	NOUN
admet-2387	62	8	ion	ion	NOUN
admet-2387	62	9	in	in	ADP
admet-2387	62	10	both	both	CCONJ
admet-2387	62	11	human	human	ADJ
admet-2387	62	12	and	and	CCONJ
admet-2387	62	13	rabbit	rabbit	NOUN
admet-2387	62	14	ocular	ocular	ADJ
admet-2387	62	15	s9	s9	NOUN
admet-2387	62	16	fractions	fraction	NOUN
admet-2387	62	17	,	,	PUNCT
admet-2387	62	18	and	and	CCONJ
admet-2387	62	19	the	the	DET
admet-2387	62	20	reactive	reactive	ADJ
admet-2387	62	21	intermediates	intermediate	NOUN
admet-2387	62	22	were	be	AUX
admet-2387	62	23	identified	identify	VERB
admet-2387	62	24	using	use	VERB
admet-2387	62	25	potassium	potassium	NOUN
admet-2387	62	26	cyanide	cyanide	NOUN
admet-2387	62	27	trapping	trap	VERB
admet-2387	62	28	methodology	methodology	NOUN
admet-2387	62	29	.	.	PUNCT
admet-2387	63	1	to	to	ADP
admet-2387	63	2	our	our	PRON
admet-2387	63	3	best	good	ADJ
admet-2387	63	4	knowledge	knowledge	NOUN
admet-2387	63	5	,	,	PUNCT
admet-2387	63	6	no	no	ADV
admet-2387	63	7	in	in	ADP
admet-2387	63	8	vivo	vivo	ADJ
admet-2387	63	9	ocular	ocular	ADJ
admet-2387	63	10	metabolism	metabolism	NOUN
admet-2387	63	11	of	of	ADP
admet-2387	63	12	ketoconazole	ketoconazole	NOUN
admet-2387	63	13	in	in	ADP
admet-2387	63	14	rats	rat	NOUN
admet-2387	63	15	has	have	AUX
admet-2387	63	16	been	be	AUX
admet-2387	63	17	reported	report	VERB
admet-2387	63	18	,	,	PUNCT
admet-2387	63	19	although	although	SCONJ
admet-2387	63	20	it	it	PRON
admet-2387	63	21	has	have	AUX
admet-2387	63	22	been	be	AUX
admet-2387	63	23	extensively	extensively	ADV
admet-2387	63	24	investigated	investigate	VERB
admet-2387	63	25	following	follow	VERB
admet-2387	63	26	oral	oral	ADJ
admet-2387	63	27	or	or	CCONJ
admet-2387	63	28	intravenous	intravenous	ADJ
admet-2387	63	29	administration	administration	NOUN
admet-2387	63	30	in	in	ADP
admet-2387	63	31	rats	rat	NOUN
admet-2387	63	32	.	.	PUNCT
admet-2387	64	1	to	to	PART
admet-2387	64	2	understand	understand	VERB
admet-2387	64	3	the	the	DET
admet-2387	64	4	metabolic	metabolic	NOUN
admet-2387	64	5	disposition	disposition	NOUN
admet-2387	64	6	of	of	ADP
admet-2387	64	7	ketoconazole	ketoconazole	NOUN
admet-2387	64	8	in	in	ADP
admet-2387	64	9	different	different	ADJ
admet-2387	64	10	eye	eye	NOUN
admet-2387	64	11	tissues	tissue	NOUN
admet-2387	64	12	,	,	PUNCT
admet-2387	64	13	we	we	PRON
admet-2387	64	14	chose	choose	VERB
admet-2387	64	15	the	the	DET
admet-2387	64	16	rat	rat	NOUN
admet-2387	64	17	to	to	PART
admet-2387	64	18	study	study	VERB
admet-2387	64	19	the	the	DET
admet-2387	64	20	ocular	ocular	ADJ
admet-2387	64	21	metabolism	metabolism	NOUN
admet-2387	64	22	of	of	ADP
admet-2387	64	23	ketoconazole	ketoconazole	NOUN
admet-2387	64	24	in	in	ADP
admet-2387	64	25	plasma	plasma	NOUN
admet-2387	64	26	,	,	PUNCT
admet-2387	64	27	cornea	cornea	NOUN
admet-2387	64	28	,	,	PUNCT
admet-2387	64	29	retina	retina	NOUN
admet-2387	64	30	,	,	PUNCT
admet-2387	64	31	and	and	CCONJ
admet-2387	64	32	vitreous	vitreous	ADJ
admet-2387	64	33	humour	humour	NOUN
admet-2387	64	34	after	after	ADP
admet-2387	64	35	a	a	DET
admet-2387	64	36	single	single	ADJ
admet-2387	64	37	topical	topical	ADJ
admet-2387	64	38	instillation	instillation	NOUN
admet-2387	64	39	administration	administration	NOUN
admet-2387	64	40	.	.	PUNCT
admet-2387	65	1	experimental	experimental	ADJ
admet-2387	65	2	chemicals	chemical	NOUN
admet-2387	65	3	and	and	CCONJ
admet-2387	65	4	reagents	reagent	NOUN
admet-2387	65	5	ketoconazole	ketoconazole	NOUN
admet-2387	65	6	(	(	PUNCT
admet-2387	65	7	slcc4160	slcc4160	PROPN
admet-2387	65	8	)	)	PUNCT
admet-2387	65	9	was	be	AUX
admet-2387	65	10	purchased	purchase	VERB
admet-2387	65	11	from	from	ADP
admet-2387	65	12	sigma	sigma	PROPN
admet-2387	65	13	in	in	ADP
admet-2387	65	14	usa	usa	PROPN
admet-2387	65	15	;	;	PUNCT
admet-2387	65	16	(	(	PUNCT
admet-2387	65	17	2	2	NUM
admet-2387	65	18	-	-	PUNCT
admet-2387	65	19	hydroxypropyl)-β	hydroxypropyl)-β	NOUN
admet-2387	65	20	-	-	PUNCT
admet-2387	65	21	cyclodextrin	cyclodextrin	NOUN
admet-2387	65	22	(	(	PUNCT
admet-2387	65	23	hpβcd	hpβcd	ADJ
admet-2387	65	24	,	,	PUNCT
admet-2387	65	25	wxbc0083v	wxbc0083v	PROPN
admet-2387	65	26	)	)	PUNCT
admet-2387	65	27	was	be	AUX
admet-2387	65	28	also	also	ADV
admet-2387	65	29	obtained	obtain	VERB
admet-2387	65	30	from	from	ADP
admet-2387	65	31	sigma	sigma	PROPN
admet-2387	65	32	in	in	ADP
admet-2387	65	33	usa	usa	PROPN
admet-2387	65	34	;	;	PUNCT
admet-2387	65	35	distilled	distil	VERB
admet-2387	65	36	h2o	h2o	PROPN
admet-2387	65	37	(	(	PUNCT
admet-2387	65	38	20190802	20190802	NUM
admet-2387	65	39	c	c	NOUN
admet-2387	65	40	)	)	PUNCT
admet-2387	65	41	was	be	AUX
admet-2387	65	42	purchased	purchase	VERB
admet-2387	65	43	from	from	ADP
admet-2387	65	44	watsons	watson	NOUN
admet-2387	65	45	in	in	ADP
admet-2387	65	46	china	china	PROPN
admet-2387	65	47	.	.	PUNCT
admet-2387	66	1	formulation	formulation	NOUN
admet-2387	66	2	preparation	preparation	NOUN
admet-2387	66	3	ketoconazole	ketoconazole	NOUN
admet-2387	66	4	was	be	AUX
admet-2387	66	5	weighed	weigh	VERB
admet-2387	66	6	and	and	CCONJ
admet-2387	66	7	dissolved	dissolve	VERB
admet-2387	66	8	in	in	ADP
admet-2387	66	9	a	a	DET
admet-2387	66	10	4	4	NUM
admet-2387	66	11	ml	ml	NOUN
admet-2387	66	12	glass	glass	NOUN
admet-2387	66	13	vial	vial	NOUN
admet-2387	66	14	,	,	PUNCT
admet-2387	66	15	and	and	CCONJ
admet-2387	66	16	then	then	ADV
admet-2387	66	17	0.083	0.083	NUM
admet-2387	66	18	ml	ml	NOUN
admet-2387	66	19	of	of	ADP
admet-2387	66	20	water	water	NOUN
admet-2387	66	21	was	be	AUX
admet-2387	66	22	added	add	VERB
admet-2387	66	23	and	and	CCONJ
admet-2387	66	24	vortexed	vortexe	VERB
admet-2387	66	25	.	.	PUNCT
admet-2387	67	1	the	the	DET
admet-2387	67	2	mixture	mixture	NOUN
admet-2387	67	3	was	be	AUX
admet-2387	67	4	stirred	stir	VERB
admet-2387	67	5	at	at	ADP
admet-2387	67	6	40	40	NUM
admet-2387	67	7	°	°	NOUN
admet-2387	67	8	c	c	NOUN
admet-2387	67	9	.	.	PUNCT
admet-2387	68	1	subsequently	subsequently	ADV
admet-2387	68	2	,	,	PUNCT
admet-2387	68	3	0.040	0.040	NUM
admet-2387	68	4	ml	ml	NOUN
admet-2387	68	5	of	of	ADP
admet-2387	68	6	1	1	NUM
admet-2387	68	7	m	m	NOUN
admet-2387	68	8	hydrochloric	hydrochloric	ADJ
admet-2387	68	9	acid	acid	NOUN
admet-2387	68	10	was	be	AUX
admet-2387	68	11	added	add	VERB
admet-2387	68	12	,	,	PUNCT
admet-2387	68	13	and	and	CCONJ
admet-2387	68	14	the	the	DET
admet-2387	68	15	mixture	mixture	NOUN
admet-2387	68	16	was	be	AUX
admet-2387	68	17	stirred	stir	VERB
admet-2387	68	18	at	at	ADP
admet-2387	68	19	40	40	NUM
admet-2387	68	20	°	°	NOUN
admet-2387	68	21	c	c	NOUN
admet-2387	68	22	until	until	SCONJ
admet-2387	68	23	it	it	PRON
admet-2387	68	24	was	be	AUX
admet-2387	68	25	completely	completely	ADV
admet-2387	68	26	dissolved	dissolve	VERB
admet-2387	68	27	.	.	PUNCT
admet-2387	69	1	0.250	0.250	NUM
admet-2387	69	2	ml	ml	NOUN
admet-2387	69	3	of	of	ADP
admet-2387	69	4	hydroxypropyl	hydroxypropyl	NOUN
admet-2387	69	5	betacyclodextrin	betacyclodextrin	NOUN
admet-2387	69	6	(	(	PUNCT
admet-2387	69	7	hpβcd	hpβcd	ADV
admet-2387	69	8	)	)	PUNCT
admet-2387	69	9	was	be	AUX
admet-2387	69	10	added	add	VERB
admet-2387	69	11	and	and	CCONJ
admet-2387	69	12	vortexed	vortexe	VERB
admet-2387	69	13	and	and	CCONJ
admet-2387	69	14	stirred	stir	VERB
admet-2387	69	15	at	at	ADP
admet-2387	69	16	40	40	NUM
admet-2387	69	17	°	°	NOUN
admet-2387	69	18	c	c	NOUN
admet-2387	69	19	until	until	ADP
admet-2387	69	20	clear	clear	ADJ
admet-2387	69	21	.	.	PUNCT
admet-2387	70	1	0.005	0.005	NUM
admet-2387	70	2	ml	ml	NOUN
admet-2387	70	3	of	of	ADP
admet-2387	70	4	1	1	NUM
admet-2387	70	5	m	m	NOUN
admet-2387	70	6	sodium	sodium	NOUN
admet-2387	70	7	hydroxide	hydroxide	NOUN
admet-2387	70	8	was	be	AUX
admet-2387	70	9	added	add	VERB
admet-2387	70	10	to	to	PART
admet-2387	70	11	adjust	adjust	VERB
admet-2387	70	12	the	the	DET
admet-2387	70	13	ph	ph	NOUN
admet-2387	70	14	to	to	ADP
admet-2387	70	15	6.5	6.5	NUM
admet-2387	70	16	-	-	SYM
admet-2387	70	17	7.0	7.0	NUM
admet-2387	70	18	while	while	SCONJ
admet-2387	70	19	stirring	stir	VERB
admet-2387	70	20	magnetically	magnetically	ADV
admet-2387	70	21	at	at	ADP
admet-2387	70	22	40	40	NUM
admet-2387	70	23	°	°	NOUN
admet-2387	70	24	c	c	NOUN
admet-2387	70	25	,	,	PUNCT
admet-2387	70	26	and	and	CCONJ
admet-2387	70	27	0.038	0.038	NUM
admet-2387	70	28	ml	ml	NOUN
admet-2387	70	29	of	of	ADP
admet-2387	70	30	water	water	NOUN
admet-2387	70	31	was	be	AUX
admet-2387	70	32	added	add	VERB
admet-2387	70	33	,	,	PUNCT
admet-2387	70	34	vortexed	vortexe	VERB
admet-2387	70	35	,	,	PUNCT
admet-2387	70	36	and	and	CCONJ
admet-2387	70	37	stirred	stir	VERB
admet-2387	70	38	at	at	ADP
admet-2387	70	39	40	40	NUM
admet-2387	70	40	°	°	NOUN
admet-2387	70	41	c	c	NOUN
admet-2387	70	42	until	until	ADP
admet-2387	70	43	clear	clear	ADJ
admet-2387	70	44	.	.	PUNCT
admet-2387	71	1	at	at	ADP
admet-2387	71	2	last	last	ADJ
admet-2387	71	3	,	,	PUNCT
admet-2387	71	4	a	a	DET
admet-2387	71	5	30	30	NUM
admet-2387	71	6	mg	mg	NUM
admet-2387	71	7	/	/	SYM
admet-2387	71	8	ml	ml	NOUN
admet-2387	71	9	ketoconazole	ketoconazole	NOUN
admet-2387	71	10	clear	clear	ADJ
admet-2387	71	11	solution	solution	NOUN
admet-2387	71	12	was	be	AUX
admet-2387	71	13	prepared	prepare	VERB
admet-2387	71	14	in	in	ADP
admet-2387	71	15	12.5	12.5	NUM
admet-2387	71	16	%	%	NOUN
admet-2387	71	17	hpβcd	hpβcd	ADJ
admet-2387	71	18	in	in	ADP
admet-2387	71	19	water	water	NOUN
admet-2387	71	20	.	.	PUNCT
admet-2387	72	1	animal	animal	NOUN
admet-2387	72	2	administration	administration	NOUN
admet-2387	72	3	all	all	DET
admet-2387	72	4	procedures	procedure	NOUN
admet-2387	72	5	performed	perform	VERB
admet-2387	72	6	on	on	ADP
admet-2387	72	7	the	the	DET
admet-2387	72	8	animals	animal	NOUN
admet-2387	72	9	were	be	AUX
admet-2387	72	10	in	in	ADP
admet-2387	72	11	accordance	accordance	NOUN
admet-2387	72	12	with	with	ADP
admet-2387	72	13	regulations	regulation	NOUN
admet-2387	72	14	and	and	CCONJ
admet-2387	72	15	established	establish	VERB
admet-2387	72	16	guidelines	guideline	NOUN
admet-2387	72	17	and	and	CCONJ
admet-2387	72	18	were	be	AUX
admet-2387	72	19	reviewed	review	VERB
admet-2387	72	20	and	and	CCONJ
admet-2387	72	21	approved	approve	VERB
admet-2387	72	22	by	by	ADP
admet-2387	72	23	an	an	DET
admet-2387	72	24	institutional	institutional	ADJ
admet-2387	72	25	animal	animal	NOUN
admet-2387	72	26	care	care	NOUN
admet-2387	72	27	and	and	CCONJ
admet-2387	72	28	use	use	VERB
admet-2387	72	29	committee	committee	NOUN
admet-2387	72	30	through	through	ADP
admet-2387	72	31	an	an	DET
admet-2387	72	32	ethical	ethical	ADJ
admet-2387	72	33	review	review	NOUN
admet-2387	72	34	process	process	NOUN
admet-2387	72	35	.	.	PUNCT
admet-2387	73	1	nine	nine	NUM
admet-2387	73	2	male	male	ADJ
admet-2387	73	3	sprague	sprague	NOUN
admet-2387	73	4	dawley	dawley	NOUN
admet-2387	73	5	rats	rat	NOUN
admet-2387	73	6	were	be	AUX
admet-2387	73	7	7	7	NUM
admet-2387	73	8	to	to	PART
admet-2387	73	9	9	9	NUM
admet-2387	73	10	weeks	week	NOUN
admet-2387	73	11	old	old	ADJ
admet-2387	73	12	and	and	CCONJ
admet-2387	73	13	purchased	purchase	VERB
admet-2387	73	14	from	from	ADP
admet-2387	73	15	vital	vital	ADJ
admet-2387	73	16	river	river	NOUN
admet-2387	73	17	(	(	PUNCT
admet-2387	73	18	zhejiang	zhejiang	PROPN
admet-2387	73	19	,	,	PUNCT
admet-2387	73	20	china	china	PROPN
admet-2387	73	21	)	)	PUNCT
admet-2387	73	22	.	.	PUNCT
admet-2387	74	1	rats	rat	NOUN
admet-2387	74	2	were	be	AUX
admet-2387	74	3	allowed	allow	VERB
admet-2387	74	4	to	to	PART
admet-2387	74	5	acclimate	acclimate	VERB
admet-2387	74	6	approximately	approximately	ADV
admet-2387	74	7	one	one	NUM
admet-2387	74	8	week	week	NOUN
admet-2387	74	9	before	before	ADP
admet-2387	74	10	treatment	treatment	NOUN
admet-2387	74	11	,	,	PUNCT
admet-2387	74	12	with	with	ADP
admet-2387	74	13	water	water	NOUN
admet-2387	74	14	and	and	CCONJ
admet-2387	74	15	food	food	NOUN
admet-2387	74	16	available	available	ADJ
admet-2387	74	17	ad	ad	NOUN
admet-2387	74	18	libitum	libitum	NOUN
admet-2387	74	19	throughout	throughout	ADP
admet-2387	74	20	the	the	DET
admet-2387	74	21	acclimation	acclimation	NOUN
admet-2387	74	22	and	and	CCONJ
admet-2387	74	23	experimental	experimental	ADJ
admet-2387	74	24	periods	period	NOUN
admet-2387	74	25	.	.	PUNCT
admet-2387	75	1	nine	nine	NUM
admet-2387	75	2	rats	rat	NOUN
admet-2387	75	3	were	be	AUX
admet-2387	75	4	randomly	randomly	ADV
admet-2387	75	5	divided	divide	VERB
admet-2387	75	6	into	into	ADP
admet-2387	75	7	three	three	NUM
admet-2387	75	8	groups	group	NOUN
admet-2387	75	9	and	and	CCONJ
admet-2387	75	10	their	their	PRON
admet-2387	75	11	body	body	NOUN
admet-2387	75	12	weights	weight	NOUN
admet-2387	75	13	were	be	AUX
admet-2387	75	14	recorded	record	VERB
admet-2387	75	15	from	from	ADP
admet-2387	75	16	254	254	NUM
admet-2387	75	17	to	to	PART
admet-2387	75	18	281	281	NUM
admet-2387	75	19	g.	g.	NOUN
admet-2387	75	20	a	a	DET
admet-2387	75	21	5	5	NUM
admet-2387	75	22	μl	μl	PROPN
admet-2387	75	23	ketoconazole	ketoconazole	NOUN
admet-2387	75	24	solution	solution	NOUN
admet-2387	75	25	(	(	PUNCT
admet-2387	75	26	30	30	NUM
admet-2387	75	27	mg	mg	NUM
admet-2387	75	28	/	/	SYM
admet-2387	75	29	ml	ml	NOUN
admet-2387	75	30	in	in	ADP
admet-2387	75	31	12.5	12.5	NUM
admet-2387	75	32	%	%	NOUN
admet-2387	75	33	hpβcd	hpβcd	ADJ
admet-2387	75	34	)	)	PUNCT
admet-2387	75	35	was	be	AUX
admet-2387	75	36	instilled	instill	VERB
admet-2387	75	37	in	in	ADP
admet-2387	75	38	both	both	DET
admet-2387	75	39	eyes	eye	NOUN
admet-2387	75	40	,	,	PUNCT
admet-2387	75	41	delivering	deliver	VERB
admet-2387	75	42	150	150	NUM
admet-2387	75	43	μg	μg	NOUN
admet-2387	75	44	per	per	ADP
admet-2387	75	45	eye	eye	NOUN
admet-2387	75	46	(	(	PUNCT
admet-2387	75	47	total	total	NOUN
admet-2387	75	48	300	300	NUM
admet-2387	75	49	μg	μg	NOUN
admet-2387	75	50	per	per	ADP
admet-2387	75	51	rat	rat	NOUN
admet-2387	75	52	)	)	PUNCT
admet-2387	75	53	over	over	ADP
admet-2387	75	54	30	30	NUM
admet-2387	75	55	seconds	second	NOUN
admet-2387	75	56	.	.	PUNCT
admet-2387	76	1	rats	rat	NOUN
admet-2387	76	2	were	be	AUX
admet-2387	76	3	sacrificed	sacrifice	VERB
admet-2387	76	4	at	at	ADP
admet-2387	76	5	5	5	NUM
admet-2387	76	6	,	,	PUNCT
admet-2387	76	7	30	30	NUM
admet-2387	76	8	and	and	CCONJ
admet-2387	76	9	120	120	NUM
admet-2387	76	10	min	min	NOUN
admet-2387	76	11	post	post	ADJ
admet-2387	76	12	-	-	ADJ
admet-2387	76	13	dose	dose	ADJ
admet-2387	76	14	(	(	PUNCT
admet-2387	76	15	n	n	NOUN
admet-2387	76	16	=	=	SYM
admet-2387	76	17	3	3	NUM
admet-2387	76	18	per	per	ADP
admet-2387	76	19	time	time	NOUN
admet-2387	76	20	point	point	NOUN
admet-2387	76	21	)	)	PUNCT
admet-2387	76	22	.	.	PUNCT
admet-2387	77	1	cornea	cornea	NOUN
admet-2387	77	2	,	,	PUNCT
admet-2387	77	3	retina	retina	NOUN
admet-2387	77	4	,	,	PUNCT
admet-2387	77	5	and	and	CCONJ
admet-2387	77	6	vitreous	vitreous	ADJ
admet-2387	77	7	humour	humour	NOUN
admet-2387	77	8	samples	sample	NOUN
admet-2387	77	9	were	be	AUX
admet-2387	77	10	collected	collect	VERB
admet-2387	77	11	,	,	PUNCT
admet-2387	77	12	washed	wash	VERB
admet-2387	77	13	in	in	ADP
admet-2387	77	14	saline	saline	NOUN
admet-2387	77	15	three	three	NUM
admet-2387	77	16	times	time	NOUN
admet-2387	77	17	and	and	CCONJ
admet-2387	77	18	weighed	weigh	VERB
admet-2387	77	19	,	,	PUNCT
admet-2387	77	20	while	while	SCONJ
admet-2387	77	21	blood	blood	NOUN
admet-2387	77	22	samples	sample	NOUN
admet-2387	77	23	were	be	AUX
admet-2387	77	24	taken	take	VERB
admet-2387	77	25	from	from	ADP
admet-2387	77	26	the	the	DET
admet-2387	77	27	heart	heart	NOUN
admet-2387	77	28	puncture	puncture	NOUN
admet-2387	77	29	.	.	PUNCT
admet-2387	78	1	tissue	tissue	NOUN
admet-2387	78	2	samples	sample	NOUN
admet-2387	78	3	were	be	AUX
admet-2387	78	4	initially	initially	ADV
admet-2387	78	5	stored	store	VERB
admet-2387	78	6	on	on	ADP
admet-2387	78	7	dry	dry	ADJ
admet-2387	78	8	ice	ice	NOUN
admet-2387	78	9	,	,	PUNCT
admet-2387	78	10	while	while	SCONJ
admet-2387	78	11	the	the	DET
admet-2387	78	12	blood	blood	NOUN
admet-2387	78	13	samples	sample	NOUN
admet-2387	78	14	were	be	AUX
admet-2387	78	15	centrifuged	centrifuge	VERB
admet-2387	78	16	at	at	ADP
admet-2387	78	17	4	4	NUM
admet-2387	78	18	°	°	ADP
admet-2387	78	19	c	c	NOUN
admet-2387	78	20	and	and	CCONJ
admet-2387	78	21	6000	6000	NUM
admet-2387	78	22	rpm	rpm	NOUN
admet-2387	78	23	for	for	ADP
admet-2387	78	24	10	10	NUM
admet-2387	78	25	min	min	NOUN
admet-2387	78	26	.	.	PROPN
admet-2387	78	27	subsequently	subsequently	ADV
admet-2387	78	28	,	,	PUNCT
admet-2387	78	29	the	the	DET
admet-2387	78	30	plasma	plasma	NOUN
admet-2387	78	31	samples	sample	NOUN
admet-2387	78	32	were	be	AUX
admet-2387	78	33	prepared	prepare	VERB
admet-2387	78	34	and	and	CCONJ
admet-2387	78	35	also	also	ADV
admet-2387	78	36	stored	store	VERB
admet-2387	78	37	on	on	ADP
admet-2387	78	38	dry	dry	ADJ
admet-2387	78	39	ice	ice	NOUN
admet-2387	78	40	.	.	PUNCT
admet-2387	79	1	ultimately	ultimately	ADV
admet-2387	79	2	,	,	PUNCT
admet-2387	79	3	all	all	DET
admet-2387	79	4	samples	sample	NOUN
admet-2387	79	5	were	be	AUX
admet-2387	79	6	cryopreserved	cryopreserve	VERB
admet-2387	79	7	in	in	ADP
admet-2387	79	8	a	a	DET
admet-2387	79	9	-80	-80	PUNCT
admet-2387	79	10	°	°	NOUN
admet-2387	79	11	c	c	NOUN
admet-2387	79	12	freezer	freezer	NOUN
admet-2387	79	13	after	after	ADP
admet-2387	79	14	harvest	harvest	NOUN
admet-2387	79	15	.	.	PUNCT
admet-2387	80	1	tissues	tissue	NOUN
admet-2387	80	2	homogenization	homogenization	NOUN
admet-2387	80	3	and	and	CCONJ
admet-2387	80	4	treatment	treatment	NOUN
admet-2387	80	5	all	all	DET
admet-2387	80	6	tissue	tissue	NOUN
admet-2387	80	7	samples	sample	NOUN
admet-2387	80	8	were	be	AUX
admet-2387	80	9	removed	remove	VERB
admet-2387	80	10	from	from	ADP
admet-2387	80	11	the	the	DET
admet-2387	80	12	-80	-80	PUNCT
admet-2387	80	13	°	°	PROPN
admet-2387	80	14	c	c	NOUN
admet-2387	80	15	freezer	freezer	NOUN
admet-2387	80	16	,	,	PUNCT
admet-2387	80	17	thawed	thaw	VERB
admet-2387	80	18	on	on	ADP
admet-2387	80	19	ice	ice	NOUN
admet-2387	80	20	,	,	PUNCT
admet-2387	80	21	and	and	CCONJ
admet-2387	80	22	0.200	0.200	NUM
admet-2387	80	23	ml	ml	NOUN
admet-2387	80	24	of	of	ADP
admet-2387	80	25	75	75	NUM
admet-2387	80	26	%	%	NOUN
admet-2387	80	27	acetonitrile	acetonitrile	NOUN
admet-2387	80	28	was	be	AUX
admet-2387	80	29	added	add	VERB
admet-2387	80	30	to	to	ADP
admet-2387	80	31	each	each	DET
admet-2387	80	32	tissue	tissue	NOUN
admet-2387	80	33	.	.	PUNCT
admet-2387	81	1	each	each	DET
admet-2387	81	2	tissue	tissue	NOUN
admet-2387	81	3	was	be	AUX
admet-2387	81	4	then	then	ADV
admet-2387	81	5	homogenized	homogenize	VERB
admet-2387	81	6	using	use	VERB
admet-2387	81	7	an	an	DET
admet-2387	81	8	ultrasonic	ultrasonic	ADJ
admet-2387	81	9	cell	cell	NOUN
admet-2387	81	10	crusher	crusher	NOUN
admet-2387	81	11	for	for	ADP
admet-2387	81	12	5	5	NUM
admet-2387	81	13	seconds	second	NOUN
admet-2387	81	14	.	.	PUNCT
admet-2387	82	1	the	the	DET
admet-2387	82	2	cornea	cornea	NOUN
admet-2387	82	3	and	and	CCONJ
admet-2387	82	4	retina	retina	PROPN
admet-2387	82	5	homogenates	homogenate	NOUN
admet-2387	82	6	were	be	AUX
admet-2387	82	7	sonicated	sonicate	VERB
admet-2387	82	8	for	for	ADP
admet-2387	82	9	10	10	NUM
admet-2387	82	10	min	min	NOUN
admet-2387	82	11	,	,	PUNCT
admet-2387	82	12	while	while	SCONJ
admet-2387	82	13	the	the	DET
admet-2387	82	14	vitreous	vitreous	ADJ
admet-2387	82	15	was	be	AUX
admet-2387	82	16	sonicated	sonicate	VERB
admet-2387	82	17	for	for	ADP
admet-2387	82	18	30	30	NUM
admet-2387	82	19	min	min	NOUN
admet-2387	82	20	at	at	ADP
admet-2387	82	21	0	0	NUM
admet-2387	82	22	°	°	ADP
admet-2387	82	23	c	c	NOUN
admet-2387	82	24	prior	prior	ADV
admet-2387	82	25	to	to	ADP
admet-2387	82	26	bioanalysis	bioanalysis	NOUN
admet-2387	82	27	.	.	PUNCT
admet-2387	83	1	the	the	DET
admet-2387	83	2	ocular	ocular	ADJ
admet-2387	83	3	tissue	tissue	NOUN
admet-2387	83	4	homogenates	homogenate	NOUN
admet-2387	83	5	were	be	AUX
admet-2387	83	6	stored	store	VERB
admet-2387	83	7	in	in	ADP
admet-2387	83	8	a	a	DET
admet-2387	83	9	-80	-80	SYM
admet-2387	83	10	°	°	NOUN
admet-2387	83	11	c	c	NOUN
admet-2387	83	12	freezer	freezer	NOUN
admet-2387	83	13	before	before	ADP
admet-2387	83	14	bioanalysis	bioanalysis	NOUN
admet-2387	83	15	.	.	PUNCT
admet-2387	84	1	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	84	2	j.	j.	PROPN
admet-2387	84	3	pu	pu	PROPN
admet-2387	84	4	et	et	PROPN
admet-2387	84	5	al	al	PROPN
admet-2387	84	6	.	.	PROPN
admet-2387	84	7	admet	admet	PROPN
admet-2387	84	8	&	&	CCONJ
admet-2387	84	9	dmpk	dmpk	PROPN
admet-2387	84	10	12(6	12(6	NUM
admet-2387	84	11	)	)	PUNCT
admet-2387	84	12	(	(	PUNCT
admet-2387	84	13	2024	2024	NUM
admet-2387	84	14	)	)	PUNCT
admet-2387	84	15	943	943	NUM
admet-2387	84	16	-	-	SYM
admet-2387	84	17	955	955	NUM
admet-2387	84	18	946	946	NUM
admet-2387	84	19	all	all	DET
admet-2387	84	20	samples	sample	NOUN
admet-2387	84	21	underwent	undergo	VERB
admet-2387	84	22	protein	protein	NOUN
admet-2387	84	23	precipitation	precipitation	NOUN
admet-2387	84	24	for	for	ADP
admet-2387	84	25	pharmacokinetic	pharmacokinetic	ADJ
admet-2387	84	26	analysis	analysis	NOUN
admet-2387	84	27	.	.	PUNCT
admet-2387	85	1	plasma	plasma	NOUN
admet-2387	85	2	and	and	CCONJ
admet-2387	85	3	three	three	NUM
admet-2387	85	4	types	type	NOUN
admet-2387	85	5	of	of	ADP
admet-2387	85	6	tissue	tissue	NOUN
admet-2387	85	7	homogenate	homogenate	NOUN
admet-2387	85	8	samples	sample	NOUN
admet-2387	85	9	(	(	PUNCT
admet-2387	85	10	50	50	NUM
admet-2387	85	11	μl	μl	NOUN
admet-2387	85	12	each	each	PRON
admet-2387	85	13	)	)	PUNCT
admet-2387	85	14	were	be	AUX
admet-2387	85	15	treated	treat	VERB
admet-2387	85	16	with	with	ADP
admet-2387	85	17	5	5	NUM
admet-2387	85	18	μl	μl	NOUN
admet-2387	85	19	of	of	ADP
admet-2387	85	20	methanol	methanol	NOUN
admet-2387	85	21	and	and	CCONJ
admet-2387	85	22	then	then	ADV
admet-2387	85	23	quenched	quench	VERB
admet-2387	85	24	with	with	ADP
admet-2387	85	25	a	a	DET
admet-2387	85	26	200	200	NUM
admet-2387	85	27	μl	μl	ADP
admet-2387	85	28	methanol	methanol	NOUN
admet-2387	85	29	and	and	CCONJ
admet-2387	85	30	acetonitrile	acetonitrile	ADJ
admet-2387	85	31	mixture	mixture	NOUN
admet-2387	85	32	(	(	PUNCT
admet-2387	85	33	1:1	1:1	NUM
admet-2387	85	34	,	,	PUNCT
admet-2387	85	35	v	v	NOUN
admet-2387	85	36	/	/	SYM
admet-2387	85	37	v	v	NOUN
admet-2387	85	38	)	)	PUNCT
admet-2387	85	39	containing	contain	VERB
admet-2387	85	40	50	50	NUM
admet-2387	85	41	ng	ng	PROPN
admet-2387	85	42	/	/	SYM
admet-2387	85	43	ml	ml	NOUN
admet-2387	85	44	terfenadine	terfenadine	NOUN
admet-2387	85	45	as	as	ADP
admet-2387	85	46	an	an	DET
admet-2387	85	47	internal	internal	ADJ
admet-2387	85	48	standard	standard	NOUN
admet-2387	85	49	(	(	PUNCT
admet-2387	85	50	istd	istd	NOUN
admet-2387	85	51	)	)	PUNCT
admet-2387	85	52	.	.	PUNCT
admet-2387	86	1	after	after	ADP
admet-2387	86	2	vortexing	vortexe	VERB
admet-2387	86	3	for	for	ADP
admet-2387	86	4	1	1	NUM
admet-2387	86	5	min	min	NOUN
admet-2387	86	6	and	and	CCONJ
admet-2387	86	7	centrifuging	centrifuge	VERB
admet-2387	86	8	at	at	ADP
admet-2387	86	9	4000	4000	NUM
admet-2387	86	10	rpm	rpm	NOUN
admet-2387	86	11	for	for	ADP
admet-2387	86	12	15	15	NUM
admet-2387	86	13	min	min	NOUN
admet-2387	86	14	,	,	PUNCT
admet-2387	86	15	the	the	DET
admet-2387	86	16	supernatant	supernatant	NOUN
admet-2387	86	17	was	be	AUX
admet-2387	86	18	transferred	transfer	VERB
admet-2387	86	19	and	and	CCONJ
admet-2387	86	20	diluted	dilute	VERB
admet-2387	86	21	10	10	NUM
admet-2387	86	22	-	-	NOUN
admet-2387	86	23	fold	fold	VERB
admet-2387	86	24	with	with	ADP
admet-2387	86	25	a	a	DET
admet-2387	86	26	methanol	methanol	NOUN
admet-2387	86	27	/	/	SYM
admet-2387	86	28	water	water	NOUN
admet-2387	86	29	solution	solution	NOUN
admet-2387	86	30	(	(	PUNCT
admet-2387	86	31	1:1	1:1	NUM
admet-2387	86	32	,	,	PUNCT
admet-2387	86	33	v	v	NOUN
admet-2387	86	34	/	/	SYM
admet-2387	86	35	v	v	NOUN
admet-2387	86	36	,	,	PUNCT
admet-2387	86	37	containing	contain	VERB
admet-2387	86	38	0.1	0.1	NUM
admet-2387	86	39	%	%	NOUN
admet-2387	86	40	formic	formic	ADJ
admet-2387	86	41	acid	acid	NOUN
admet-2387	86	42	)	)	PUNCT
admet-2387	86	43	for	for	ADP
admet-2387	86	44	lc	lc	PROPN
admet-2387	86	45	-	-	PUNCT
admet-2387	86	46	ms	ms	PROPN
admet-2387	86	47	/	/	SYM
admet-2387	86	48	ms	ms	NOUN
admet-2387	86	49	analysis	analysis	NOUN
admet-2387	86	50	.	.	PUNCT
admet-2387	87	1	the	the	DET
admet-2387	87	2	working	work	VERB
admet-2387	87	3	solution	solution	NOUN
admet-2387	87	4	was	be	AUX
admet-2387	87	5	prepared	prepare	VERB
admet-2387	87	6	with	with	ADP
admet-2387	87	7	a	a	DET
admet-2387	87	8	concentration	concentration	NOUN
admet-2387	87	9	range	range	NOUN
admet-2387	87	10	of	of	ADP
admet-2387	87	11	50.0	50.0	NUM
admet-2387	87	12	to	to	PART
admet-2387	87	13	100,000	100,000	NUM
admet-2387	87	14	ng	ng	PROPN
admet-2387	87	15	/	/	SYM
admet-2387	87	16	ml	ml	PROPN
admet-2387	87	17	.	.	PUNCT
admet-2387	88	1	the	the	DET
admet-2387	88	2	ketoconazole	ketoconazole	PROPN
admet-2387	88	3	standard	standard	PROPN
admet-2387	88	4	curve	curve	NOUN
admet-2387	88	5	for	for	ADP
admet-2387	88	6	corneal	corneal	ADJ
admet-2387	88	7	homogenates	homogenate	NOUN
admet-2387	88	8	ranged	range	VERB
admet-2387	88	9	from	from	ADP
admet-2387	88	10	5.00	5.00	NUM
admet-2387	88	11	to	to	PART
admet-2387	88	12	10,000	10,000	NUM
admet-2387	88	13	ng	ng	NOUN
admet-2387	88	14	/	/	SYM
admet-2387	88	15	ml	ml	PROPN
admet-2387	88	16	,	,	PUNCT
admet-2387	88	17	whereas	whereas	SCONJ
admet-2387	88	18	for	for	ADP
admet-2387	88	19	retina	retina	NOUN
admet-2387	88	20	and	and	CCONJ
admet-2387	88	21	vitreous	vitreous	ADJ
admet-2387	88	22	humour	humour	NOUN
admet-2387	88	23	homogenates	homogenate	NOUN
admet-2387	88	24	,	,	PUNCT
admet-2387	88	25	it	it	PRON
admet-2387	88	26	ranged	range	VERB
admet-2387	88	27	from	from	ADP
admet-2387	88	28	1.00	1.00	NUM
admet-2387	88	29	to	to	ADP
admet-2387	88	30	2,000	2,000	NUM
admet-2387	88	31	ng	ng	NOUN
admet-2387	88	32	/	/	SYM
admet-2387	88	33	ml	ml	PROPN
admet-2387	88	34	.	.	PUNCT
admet-2387	89	1	rat	rat	NOUN
admet-2387	89	2	plasma	plasma	NOUN
admet-2387	89	3	(	(	PUNCT
admet-2387	89	4	400	400	NUM
admet-2387	89	5	l	l	PROPN
admet-2387	89	6	,	,	PUNCT
admet-2387	89	7	44.4	44.4	NUM
admet-2387	89	8	l	l	NOUN
admet-2387	89	9	/	/	SYM
admet-2387	89	10	rat	rat	NOUN
admet-2387	89	11	at	at	ADP
admet-2387	89	12	each	each	DET
admet-2387	89	13	time	time	NOUN
admet-2387	89	14	point	point	NOUN
admet-2387	89	15	)	)	PUNCT
admet-2387	89	16	was	be	AUX
admet-2387	89	17	pooled	pool	VERB
admet-2387	89	18	from	from	ADP
admet-2387	89	19	3	3	NUM
admet-2387	89	20	-	-	PUNCT
admet-2387	89	21	time	time	NOUN
admet-2387	89	22	points	point	NOUN
admet-2387	89	23	utilizing	utilize	VERB
admet-2387	89	24	the	the	DET
admet-2387	89	25	equal	equal	ADJ
admet-2387	89	26	volume	volume	NOUN
admet-2387	89	27	method	method	NOUN
admet-2387	89	28	and	and	CCONJ
admet-2387	89	29	subsequently	subsequently	ADV
admet-2387	89	30	precipitated	precipitate	VERB
admet-2387	89	31	with	with	ADP
admet-2387	89	32	acetonitrile	acetonitrile	NOUN
admet-2387	89	33	containing	contain	VERB
admet-2387	89	34	0.1	0.1	NUM
admet-2387	89	35	%	%	NOUN
admet-2387	89	36	formic	formic	ADJ
admet-2387	89	37	acid	acid	NOUN
admet-2387	89	38	at	at	ADP
admet-2387	89	39	a	a	DET
admet-2387	89	40	ratio	ratio	NOUN
admet-2387	89	41	of	of	ADP
admet-2387	89	42	1:3	1:3	NUM
admet-2387	89	43	.	.	PUNCT
admet-2387	90	1	homogenate	homogenate	NOUN
admet-2387	90	2	samples	sample	NOUN
admet-2387	90	3	of	of	ADP
admet-2387	90	4	rat	rat	NOUN
admet-2387	90	5	cornea	cornea	NOUN
admet-2387	90	6	,	,	PUNCT
admet-2387	90	7	retina	retina	NOUN
admet-2387	90	8	,	,	PUNCT
admet-2387	90	9	and	and	CCONJ
admet-2387	90	10	vitreous	vitreous	ADJ
admet-2387	90	11	humour	humour	NOUN
admet-2387	90	12	(	(	PUNCT
admet-2387	90	13	600	600	NUM
admet-2387	90	14	l	l	NOUN
admet-2387	90	15	,	,	PUNCT
admet-2387	90	16	66.7	66.7	NUM
admet-2387	90	17	l	l	NOUN
admet-2387	90	18	/rat	/rat	PUNCT
admet-2387	90	19	)	)	PUNCT
admet-2387	90	20	were	be	AUX
admet-2387	90	21	pooled	pool	VERB
admet-2387	90	22	from	from	ADP
admet-2387	90	23	three	three	NUM
admet-2387	90	24	time	time	NOUN
admet-2387	90	25	points	point	NOUN
admet-2387	90	26	individually	individually	ADV
admet-2387	90	27	utilizing	utilize	VERB
admet-2387	90	28	the	the	DET
admet-2387	90	29	equal	equal	ADJ
admet-2387	90	30	volume	volume	NOUN
admet-2387	90	31	and	and	CCONJ
admet-2387	90	32	transferred	transfer	VERB
admet-2387	90	33	into	into	ADP
admet-2387	90	34	a	a	DET
admet-2387	90	35	15	15	NUM
admet-2387	90	36	ml	ml	NOUN
admet-2387	90	37	centrifuge	centrifuge	NOUN
admet-2387	90	38	tube	tube	NOUN
admet-2387	90	39	and	and	CCONJ
admet-2387	90	40	subjected	subject	VERB
admet-2387	90	41	to	to	ADP
admet-2387	90	42	precipitation	precipitation	NOUN
admet-2387	90	43	with	with	ADP
admet-2387	90	44	acetonitrile	acetonitrile	NOUN
admet-2387	90	45	containing	contain	VERB
admet-2387	90	46	0.1	0.1	NUM
admet-2387	90	47	%	%	NOUN
admet-2387	90	48	formic	formic	ADJ
admet-2387	90	49	acid	acid	NOUN
admet-2387	90	50	at	at	ADP
admet-2387	90	51	the	the	DET
admet-2387	90	52	same	same	ADJ
admet-2387	90	53	ratio	ratio	NOUN
admet-2387	90	54	of	of	ADP
admet-2387	90	55	1:3	1:3	NUM
admet-2387	90	56	.	.	PUNCT
admet-2387	91	1	following	follow	VERB
admet-2387	91	2	centrifugation	centrifugation	NOUN
admet-2387	91	3	,	,	PUNCT
admet-2387	91	4	the	the	DET
admet-2387	91	5	supernatant	supernatant	NOUN
admet-2387	91	6	was	be	AUX
admet-2387	91	7	evaporated	evaporate	VERB
admet-2387	91	8	under	under	ADP
admet-2387	91	9	a	a	DET
admet-2387	91	10	stream	stream	NOUN
admet-2387	91	11	of	of	ADP
admet-2387	91	12	nitrogen	nitrogen	NOUN
admet-2387	91	13	gas	gas	NOUN
admet-2387	91	14	.	.	PUNCT
admet-2387	92	1	the	the	DET
admet-2387	92	2	residues	residue	NOUN
admet-2387	92	3	from	from	ADP
admet-2387	92	4	plasma	plasma	NOUN
admet-2387	92	5	and	and	CCONJ
admet-2387	92	6	rat	rat	NOUN
admet-2387	92	7	retina	retina	NOUN
admet-2387	92	8	were	be	AUX
admet-2387	92	9	reconstituted	reconstitute	VERB
admet-2387	92	10	with	with	ADP
admet-2387	92	11	150	150	NUM
admet-2387	92	12	l	l	NOUN
admet-2387	92	13	of	of	ADP
admet-2387	92	14	10	10	NUM
admet-2387	92	15	%	%	NOUN
admet-2387	92	16	acetonitrile	acetonitrile	NOUN
admet-2387	92	17	in	in	ADP
admet-2387	92	18	h2o	h2o	PROPN
admet-2387	92	19	(	(	PUNCT
admet-2387	92	20	with	with	ADP
admet-2387	92	21	0.1	0.1	NUM
admet-2387	92	22	%	%	NOUN
admet-2387	92	23	formic	formic	ADJ
admet-2387	92	24	acid	acid	NOUN
admet-2387	92	25	)	)	PUNCT
admet-2387	92	26	,	,	PUNCT
admet-2387	92	27	while	while	SCONJ
admet-2387	92	28	the	the	DET
admet-2387	92	29	residues	residue	NOUN
admet-2387	92	30	from	from	ADP
admet-2387	92	31	the	the	DET
admet-2387	92	32	rat	rat	NOUN
admet-2387	92	33	cornea	cornea	NOUN
admet-2387	92	34	and	and	CCONJ
admet-2387	92	35	vitreous	vitreous	ADJ
admet-2387	92	36	humour	humour	NOUN
admet-2387	92	37	were	be	AUX
admet-2387	92	38	reconstituted	reconstitute	VERB
admet-2387	92	39	with	with	ADP
admet-2387	92	40	100	100	NUM
admet-2387	92	41	l	l	NOUN
admet-2387	92	42	of	of	ADP
admet-2387	92	43	10	10	NUM
admet-2387	92	44	%	%	NOUN
admet-2387	92	45	acetonitrile	acetonitrile	NOUN
admet-2387	92	46	in	in	ADP
admet-2387	92	47	h2o	h2o	PROPN
admet-2387	92	48	(	(	PUNCT
admet-2387	92	49	0.1	0.1	NUM
admet-2387	92	50	%	%	NOUN
admet-2387	92	51	formic	formic	ADJ
admet-2387	92	52	acid	acid	NOUN
admet-2387	92	53	)	)	PUNCT
admet-2387	92	54	.	.	PUNCT
admet-2387	93	1	four	four	NUM
admet-2387	93	2	types	type	NOUN
admet-2387	93	3	of	of	ADP
admet-2387	93	4	blank	blank	ADJ
admet-2387	93	5	samples	sample	NOUN
admet-2387	93	6	were	be	AUX
admet-2387	93	7	processed	process	VERB
admet-2387	93	8	in	in	ADP
admet-2387	93	9	a	a	DET
admet-2387	93	10	similar	similar	ADJ
admet-2387	93	11	manner	manner	NOUN
admet-2387	93	12	.	.	PUNCT
admet-2387	94	1	ultimately	ultimately	ADV
admet-2387	94	2	,	,	PUNCT
admet-2387	94	3	10	10	NUM
admet-2387	94	4	l	l	PROPN
admet-2387	94	5	samples	sample	NOUN
admet-2387	94	6	of	of	ADP
admet-2387	94	7	each	each	DET
admet-2387	94	8	tissue	tissue	NOUN
admet-2387	94	9	were	be	AUX
admet-2387	94	10	injected	inject	VERB
admet-2387	94	11	for	for	ADP
admet-2387	94	12	analysis	analysis	NOUN
admet-2387	94	13	using	use	VERB
admet-2387	94	14	the	the	DET
admet-2387	94	15	ultimate	ultimate	ADJ
admet-2387	94	16	3000	3000	NUM
admet-2387	94	17	-	-	PUNCT
admet-2387	94	18	q	q	NOUN
admet-2387	94	19	-	-	PUNCT
admet-2387	94	20	exactive	exactive	ADJ
admet-2387	94	21	plus	plus	CCONJ
admet-2387	94	22	system	system	NOUN
admet-2387	94	23	.	.	PUNCT
admet-2387	95	1	liquid	liquid	ADJ
admet-2387	95	2	chromatography	chromatography	NOUN
admet-2387	95	3	-	-	PUNCT
admet-2387	95	4	mass	mass	NOUN
admet-2387	95	5	spectrometry	spectrometry	NOUN
admet-2387	95	6	analysis	analysis	NOUN
admet-2387	95	7	the	the	DET
admet-2387	95	8	quantitative	quantitative	ADJ
admet-2387	95	9	sample	sample	NOUN
admet-2387	95	10	analysis	analysis	NOUN
admet-2387	95	11	was	be	AUX
admet-2387	95	12	performed	perform	VERB
admet-2387	95	13	on	on	ADP
admet-2387	95	14	a	a	DET
admet-2387	95	15	shimadzu	shimadzu	ADJ
admet-2387	95	16	lc-20ad	lc-20ad	PROPN
admet-2387	95	17	(	(	PUNCT
admet-2387	95	18	shimadzu	shimadzu	PROPN
admet-2387	95	19	,	,	PUNCT
admet-2387	95	20	japan	japan	PROPN
admet-2387	95	21	)	)	PUNCT
admet-2387	95	22	api	api	NOUN
admet-2387	95	23	4000	4000	NUM
admet-2387	95	24	mass	mass	NOUN
admet-2387	95	25	spectrometer	spectrometer	NOUN
admet-2387	95	26	(	(	PUNCT
admet-2387	95	27	sciex	sciex	NOUN
admet-2387	95	28	,	,	PUNCT
admet-2387	95	29	canada	canada	PROPN
admet-2387	95	30	)	)	PUNCT
admet-2387	95	31	.	.	PUNCT
admet-2387	96	1	the	the	DET
admet-2387	96	2	chromatographic	chromatographic	ADJ
admet-2387	96	3	separation	separation	NOUN
admet-2387	96	4	of	of	ADP
admet-2387	96	5	analytes	analyte	NOUN
admet-2387	96	6	from	from	ADP
admet-2387	96	7	the	the	DET
admet-2387	96	8	matrix	matrix	NOUN
admet-2387	96	9	was	be	AUX
admet-2387	96	10	achieved	achieve	VERB
admet-2387	96	11	on	on	ADP
admet-2387	96	12	a	a	DET
admet-2387	96	13	kinetex	kinetex	NOUN
admet-2387	96	14	2.6	2.6	NUM
admet-2387	96	15	µm	µm	ADP
admet-2387	96	16	c18	c18	NOUN
admet-2387	96	17	100a	100a	NUM
admet-2387	96	18	column	column	NOUN
admet-2387	96	19	(	(	PUNCT
admet-2387	96	20	3	3	NUM
admet-2387	96	21	30	30	NUM
admet-2387	96	22	mm	mm	NOUN
admet-2387	96	23	)	)	PUNCT
admet-2387	96	24	at	at	ADP
admet-2387	96	25	room	room	NOUN
admet-2387	96	26	temperature	temperature	NOUN
admet-2387	96	27	with	with	ADP
admet-2387	96	28	a	a	DET
admet-2387	96	29	flow	flow	NOUN
admet-2387	96	30	rate	rate	NOUN
admet-2387	96	31	of	of	ADP
admet-2387	96	32	0.7	0.7	NUM
admet-2387	96	33	ml	ml	NOUN
admet-2387	96	34	/	/	SYM
admet-2387	96	35	min	min	NOUN
admet-2387	96	36	.	.	PROPN
admet-2387	96	37	for	for	ADP
admet-2387	96	38	plasma	plasma	NOUN
admet-2387	96	39	analysis	analysis	NOUN
admet-2387	96	40	,	,	PUNCT
admet-2387	96	41	mobile	mobile	ADJ
admet-2387	96	42	phase	phase	NOUN
admet-2387	96	43	a	a	DET
admet-2387	96	44	consisted	consisted	NOUN
admet-2387	96	45	of	of	ADP
admet-2387	96	46	5	5	NUM
admet-2387	96	47	mm	mm	NOUN
admet-2387	96	48	ammonium	ammonium	NOUN
admet-2387	96	49	acetate	acetate	NOUN
admet-2387	96	50	in	in	ADP
admet-2387	96	51	distilled	distil	VERB
admet-2387	96	52	water	water	NOUN
admet-2387	96	53	(	(	PUNCT
admet-2387	96	54	with	with	ADP
admet-2387	96	55	0.05	0.05	NUM
admet-2387	96	56	%	%	NOUN
admet-2387	96	57	formic	formic	ADJ
admet-2387	96	58	acid	acid	NOUN
admet-2387	96	59	)	)	PUNCT
admet-2387	96	60	,	,	PUNCT
admet-2387	96	61	and	and	CCONJ
admet-2387	96	62	mobile	mobile	ADJ
admet-2387	96	63	phase	phase	NOUN
admet-2387	96	64	b	b	NOUN
admet-2387	96	65	consisted	consist	VERB
admet-2387	96	66	of	of	ADP
admet-2387	96	67	acetonitrile	acetonitrile	NOUN
admet-2387	96	68	(	(	PUNCT
admet-2387	96	69	with	with	ADP
admet-2387	96	70	0.1	0.1	NUM
admet-2387	96	71	%	%	NOUN
admet-2387	96	72	formic	formic	ADJ
admet-2387	96	73	acid	acid	NOUN
admet-2387	96	74	)	)	PUNCT
admet-2387	96	75	.	.	PUNCT
admet-2387	97	1	a	a	DET
admet-2387	97	2	step	step	NOUN
admet-2387	97	3	time	time	NOUN
admet-2387	97	4	gradient	gradient	NOUN
admet-2387	97	5	started	start	VERB
admet-2387	97	6	by	by	ADP
admet-2387	97	7	maintaining	maintain	VERB
admet-2387	97	8	15	15	NUM
admet-2387	97	9	%	%	NOUN
admet-2387	97	10	mobile	mobile	ADJ
admet-2387	97	11	phase	phase	NOUN
admet-2387	97	12	b	b	PROPN
admet-2387	97	13	for	for	ADP
admet-2387	97	14	0.4	0.4	NUM
admet-2387	97	15	min	min	NOUN
admet-2387	97	16	,	,	PUNCT
admet-2387	97	17	transitioning	transition	VERB
admet-2387	97	18	from	from	ADP
admet-2387	97	19	15	15	NUM
admet-2387	97	20	to	to	PART
admet-2387	97	21	95	95	NUM
admet-2387	97	22	%	%	NOUN
admet-2387	97	23	mobile	mobile	ADJ
admet-2387	97	24	phase	phase	NOUN
admet-2387	97	25	b	b	NOUN
admet-2387	97	26	over	over	ADP
admet-2387	97	27	1.8	1.8	NUM
admet-2387	97	28	min	min	NOUN
admet-2387	97	29	,	,	PUNCT
admet-2387	97	30	holding	hold	VERB
admet-2387	97	31	at	at	ADP
admet-2387	97	32	95	95	NUM
admet-2387	97	33	%	%	NOUN
admet-2387	97	34	mobile	mobile	ADJ
admet-2387	97	35	phase	phase	NOUN
admet-2387	97	36	b	b	NOUN
admet-2387	97	37	for	for	ADP
admet-2387	97	38	0.3	0.3	NUM
admet-2387	97	39	min	min	NOUN
admet-2387	97	40	,	,	PUNCT
admet-2387	97	41	then	then	ADV
admet-2387	97	42	returning	return	VERB
admet-2387	97	43	to	to	ADP
admet-2387	97	44	15	15	NUM
admet-2387	97	45	%	%	NOUN
admet-2387	97	46	b	b	NOUN
admet-2387	97	47	in	in	ADP
admet-2387	97	48	0.01	0.01	NUM
admet-2387	97	49	min	min	NOUN
admet-2387	97	50	and	and	CCONJ
admet-2387	97	51	re	re	ADJ
admet-2387	97	52	-	-	VERB
admet-2387	97	53	equilibrating	equilibrate	VERB
admet-2387	97	54	for	for	ADP
admet-2387	97	55	0.49	0.49	NUM
admet-2387	97	56	min	min	NOUN
admet-2387	97	57	.	.	PROPN
admet-2387	97	58	for	for	ADP
admet-2387	97	59	the	the	DET
admet-2387	97	60	cornea	cornea	NOUN
admet-2387	97	61	,	,	PUNCT
admet-2387	97	62	retina	retina	NOUN
admet-2387	97	63	,	,	PUNCT
admet-2387	97	64	and	and	CCONJ
admet-2387	97	65	vitreous	vitreous	ADJ
admet-2387	97	66	humour	humour	NOUN
admet-2387	97	67	,	,	PUNCT
admet-2387	97	68	a	a	DET
admet-2387	97	69	step	step	NOUN
admet-2387	97	70	time	time	NOUN
admet-2387	97	71	gradient	gradient	NOUN
admet-2387	97	72	started	start	VERB
admet-2387	97	73	by	by	ADP
admet-2387	97	74	maintaining	maintain	VERB
admet-2387	97	75	15	15	NUM
admet-2387	97	76	%	%	NOUN
admet-2387	97	77	mobile	mobile	ADJ
admet-2387	97	78	phase	phase	NOUN
admet-2387	97	79	b	b	PROPN
admet-2387	97	80	for	for	ADP
admet-2387	97	81	0.4	0.4	NUM
admet-2387	97	82	min	min	NOUN
admet-2387	97	83	,	,	PUNCT
admet-2387	97	84	transitioning	transition	VERB
admet-2387	97	85	from	from	ADP
admet-2387	97	86	15	15	NUM
admet-2387	97	87	to	to	PART
admet-2387	97	88	95	95	NUM
admet-2387	97	89	%	%	NOUN
admet-2387	97	90	mobile	mobile	ADJ
admet-2387	97	91	phase	phase	NOUN
admet-2387	97	92	b	b	NOUN
admet-2387	97	93	over	over	ADP
admet-2387	97	94	0.8	0.8	NUM
admet-2387	97	95	min	min	NOUN
admet-2387	97	96	,	,	PUNCT
admet-2387	97	97	maintaining	maintain	VERB
admet-2387	97	98	95	95	NUM
admet-2387	97	99	%	%	NOUN
admet-2387	97	100	mobile	mobile	ADJ
admet-2387	97	101	phase	phase	NOUN
admet-2387	97	102	b	b	PROPN
admet-2387	97	103	for	for	ADP
admet-2387	97	104	0.6	0.6	NUM
admet-2387	97	105	min	min	NOUN
admet-2387	97	106	,	,	PUNCT
admet-2387	97	107	then	then	ADV
admet-2387	97	108	returning	return	VERB
admet-2387	97	109	to	to	ADP
admet-2387	97	110	15	15	NUM
admet-2387	97	111	%	%	NOUN
admet-2387	97	112	b	b	NOUN
admet-2387	97	113	in	in	ADP
admet-2387	97	114	0.01	0.01	NUM
admet-2387	97	115	min	min	NOUN
admet-2387	97	116	and	and	CCONJ
admet-2387	97	117	re	re	ADJ
admet-2387	97	118	-	-	VERB
admet-2387	97	119	equilibrating	equilibrate	VERB
admet-2387	97	120	for	for	ADP
admet-2387	97	121	0.69	0.69	NUM
admet-2387	97	122	min	min	NOUN
admet-2387	97	123	.	.	PROPN
admet-2387	97	124	ketoconazole	ketoconazole	PROPN
admet-2387	97	125	was	be	AUX
admet-2387	97	126	detected	detect	VERB
admet-2387	97	127	and	and	CCONJ
admet-2387	97	128	quantified	quantify	VERB
admet-2387	97	129	by	by	ADP
admet-2387	97	130	performing	perform	VERB
admet-2387	97	131	positive	positive	ADJ
admet-2387	97	132	-	-	PUNCT
admet-2387	97	133	ion	ion	NOUN
admet-2387	97	134	electrospray	electrospray	NOUN
admet-2387	97	135	tandem	tandem	PROPN
admet-2387	97	136	mass	mass	ADJ
admet-2387	97	137	spectrometry	spectrometry	NOUN
admet-2387	97	138	at	at	ADP
admet-2387	97	139	4500	4500	NUM
admet-2387	97	140	v	v	NOUN
admet-2387	97	141	and	and	CCONJ
admet-2387	98	1	550	550	NUM
admet-2387	98	2	°	°	NOUN
admet-2387	98	3	c	c	NOUN
admet-2387	98	4	,	,	PUNCT
admet-2387	98	5	with	with	ADP
admet-2387	98	6	multiple	multiple	ADJ
admet-2387	98	7	reaction	reaction	NOUN
admet-2387	98	8	monitoring	monitoring	NOUN
admet-2387	98	9	modes	mode	NOUN
admet-2387	98	10	of	of	ADP
admet-2387	98	11	ion	ion	NOUN
admet-2387	98	12	transition	transition	NOUN
admet-2387	98	13	m	m	PROPN
admet-2387	98	14	/	/	SYM
admet-2387	98	15	z	z	PROPN
admet-2387	98	16	531.2	531.2	NUM
admet-2387	98	17	to	to	ADP
admet-2387	98	18	489.2	489.2	NUM
admet-2387	98	19	for	for	ADP
admet-2387	98	20	ketoconazole	ketoconazole	NOUN
admet-2387	98	21	and	and	CCONJ
admet-2387	98	22	m	m	PROPN
admet-2387	98	23	/	/	SYM
admet-2387	98	24	z	z	PROPN
admet-2387	98	25	472.4	472.4	NUM
admet-2387	98	26	to	to	ADP
admet-2387	98	27	436.4	436.4	NUM
admet-2387	98	28	for	for	ADP
admet-2387	98	29	terfenadine	terfenadine	NOUN
admet-2387	98	30	(	(	PUNCT
admet-2387	98	31	istd	istd	NOUN
admet-2387	98	32	)	)	PUNCT
admet-2387	98	33	.	.	PUNCT
admet-2387	99	1	the	the	DET
admet-2387	99	2	metabolite	metabolite	NOUN
admet-2387	99	3	identification	identification	NOUN
admet-2387	99	4	and	and	CCONJ
admet-2387	99	5	analysis	analysis	NOUN
admet-2387	99	6	were	be	AUX
admet-2387	99	7	conducted	conduct	VERB
admet-2387	99	8	on	on	ADP
admet-2387	99	9	an	an	DET
admet-2387	99	10	ultimate	ultimate	ADJ
admet-2387	99	11	3000	3000	NUM
admet-2387	99	12	q	q	ADJ
admet-2387	99	13	-	-	PUNCT
admet-2387	99	14	exactive	exactive	ADJ
admet-2387	99	15	plus	plus	CCONJ
admet-2387	99	16	high	high	ADJ
admet-2387	99	17	-	-	PUNCT
admet-2387	99	18	resolution	resolution	NOUN
admet-2387	99	19	mass	mass	NOUN
admet-2387	99	20	spectrometer	spectrometer	NOUN
admet-2387	99	21	(	(	PUNCT
admet-2387	99	22	thermo	thermo	NOUN
admet-2387	99	23	fisher	fisher	PROPN
admet-2387	99	24	scientific	scientific	PROPN
admet-2387	99	25	,	,	PUNCT
admet-2387	99	26	germany	germany	PROPN
admet-2387	99	27	)	)	PUNCT
admet-2387	99	28	,	,	PUNCT
admet-2387	99	29	ketoconazole	ketoconazole	NOUN
admet-2387	99	30	and	and	CCONJ
admet-2387	99	31	its	its	PRON
admet-2387	99	32	metabolites	metabolite	NOUN
admet-2387	99	33	were	be	AUX
admet-2387	99	34	injected	inject	VERB
admet-2387	99	35	and	and	CCONJ
admet-2387	99	36	separated	separate	VERB
admet-2387	99	37	using	use	VERB
admet-2387	99	38	an	an	DET
admet-2387	99	39	acquity	acquity	NOUN
admet-2387	99	40	uplc	uplc	ADJ
admet-2387	99	41	®	®	NOUN
admet-2387	99	42	hss	hss	PROPN
admet-2387	99	43	t3	t3	PROPN
admet-2387	99	44	column	column	NOUN
admet-2387	99	45	(	(	PUNCT
admet-2387	99	46	1.8	1.8	NUM
admet-2387	99	47	µm	µm	NOUN
admet-2387	99	48	,	,	PUNCT
admet-2387	99	49	2.1×100	2.1×100	NUM
admet-2387	99	50	mm	mm	NOUN
admet-2387	99	51	)	)	PUNCT
admet-2387	99	52	at	at	ADP
admet-2387	99	53	room	room	NOUN
admet-2387	99	54	temperature	temperature	NOUN
admet-2387	99	55	with	with	ADP
admet-2387	99	56	a	a	DET
admet-2387	99	57	flow	flow	NOUN
admet-2387	99	58	rate	rate	NOUN
admet-2387	99	59	of	of	ADP
admet-2387	99	60	0.3	0.3	NUM
admet-2387	99	61	ml	ml	NOUN
admet-2387	99	62	/	/	SYM
admet-2387	99	63	min	min	PROPN
admet-2387	99	64	.	.	PROPN
admet-2387	99	65	mobile	mobile	ADJ
admet-2387	99	66	phase	phase	NOUN
admet-2387	99	67	a	a	DET
admet-2387	99	68	consisted	consisted	NOUN
admet-2387	99	69	of	of	ADP
admet-2387	99	70	water	water	NOUN
admet-2387	99	71	containing	contain	VERB
admet-2387	99	72	0.1	0.1	NUM
admet-2387	99	73	%	%	NOUN
admet-2387	99	74	formic	formic	ADJ
admet-2387	99	75	acid	acid	NOUN
admet-2387	99	76	,	,	PUNCT
admet-2387	99	77	while	while	SCONJ
admet-2387	99	78	mobile	mobile	ADJ
admet-2387	99	79	phase	phase	NOUN
admet-2387	99	80	b	b	NOUN
admet-2387	99	81	consisted	consist	VERB
admet-2387	99	82	of	of	ADP
admet-2387	99	83	acetonitrile	acetonitrile	NOUN
admet-2387	99	84	with	with	ADP
admet-2387	99	85	0.1	0.1	NUM
admet-2387	99	86	%	%	NOUN
admet-2387	99	87	formic	formic	ADJ
admet-2387	99	88	acid	acid	NOUN
admet-2387	99	89	.	.	PUNCT
admet-2387	100	1	chromatographic	chromatographic	ADJ
admet-2387	100	2	separation	separation	NOUN
admet-2387	100	3	was	be	AUX
admet-2387	100	4	achieved	achieve	VERB
admet-2387	100	5	with	with	ADP
admet-2387	100	6	a	a	DET
admet-2387	100	7	step	step	NOUN
admet-2387	100	8	time	time	NOUN
admet-2387	100	9	gradient	gradient	ADJ
admet-2387	100	10	by	by	ADP
admet-2387	100	11	maintaining	maintain	VERB
admet-2387	100	12	5	5	NUM
admet-2387	100	13	%	%	NOUN
admet-2387	100	14	mobile	mobile	ADJ
admet-2387	100	15	phase	phase	NOUN
admet-2387	100	16	b	b	NOUN
admet-2387	100	17	for	for	ADP
admet-2387	100	18	1.0	1.0	NUM
admet-2387	100	19	min	min	NOUN
admet-2387	100	20	,	,	PUNCT
admet-2387	100	21	increasing	increase	VERB
admet-2387	100	22	from	from	ADP
admet-2387	100	23	5	5	NUM
admet-2387	100	24	to	to	PART
admet-2387	100	25	25	25	NUM
admet-2387	100	26	%	%	NOUN
admet-2387	100	27	mobile	mobile	ADJ
admet-2387	100	28	phase	phase	NOUN
admet-2387	100	29	b	b	NOUN
admet-2387	100	30	over	over	ADP
admet-2387	100	31	5.0	5.0	NUM
admet-2387	100	32	min	min	NOUN
admet-2387	100	33	,	,	PUNCT
admet-2387	100	34	further	far	ADV
admet-2387	100	35	increasing	increase	VERB
admet-2387	100	36	from	from	ADP
admet-2387	100	37	25	25	NUM
admet-2387	100	38	to	to	PART
admet-2387	100	39	40	40	NUM
admet-2387	100	40	%	%	NOUN
admet-2387	100	41	mobile	mobile	ADJ
admet-2387	100	42	phase	phase	NOUN
admet-2387	100	43	b	b	NOUN
admet-2387	100	44	over	over	ADP
admet-2387	100	45	8.0	8.0	NUM
admet-2387	100	46	min	min	NOUN
admet-2387	100	47	,	,	PUNCT
admet-2387	100	48	then	then	ADV
admet-2387	100	49	from	from	ADP
admet-2387	100	50	40	40	NUM
admet-2387	100	51	to	to	PART
admet-2387	100	52	95	95	NUM
admet-2387	100	53	%	%	NOUN
admet-2387	100	54	mobile	mobile	ADJ
admet-2387	100	55	phase	phase	NOUN
admet-2387	100	56	b	b	NOUN
admet-2387	100	57	over	over	ADP
admet-2387	100	58	3.0	3.0	NUM
admet-2387	100	59	min	min	NOUN
admet-2387	100	60	,	,	PUNCT
admet-2387	100	61	maintaining	maintain	VERB
admet-2387	100	62	95	95	NUM
admet-2387	100	63	%	%	NOUN
admet-2387	100	64	mobile	mobile	ADJ
admet-2387	100	65	phase	phase	NOUN
admet-2387	100	66	b	b	NOUN
admet-2387	100	67	for	for	ADP
admet-2387	100	68	2.0	2.0	NUM
admet-2387	100	69	min	min	NOUN
admet-2387	100	70	,	,	PUNCT
admet-2387	100	71	and	and	CCONJ
admet-2387	100	72	finally	finally	ADV
admet-2387	100	73	returning	return	VERB
admet-2387	100	74	to	to	ADP
admet-2387	100	75	5	5	NUM
admet-2387	100	76	%	%	NOUN
admet-2387	100	77	b	b	NOUN
admet-2387	100	78	in	in	ADP
admet-2387	100	79	0.1	0.1	NUM
admet-2387	100	80	min	min	NOUN
admet-2387	100	81	and	and	CCONJ
admet-2387	100	82	re	re	ADJ
admet-2387	100	83	-	-	VERB
admet-2387	100	84	equilibrating	equilibrate	VERB
admet-2387	100	85	for	for	ADP
admet-2387	100	86	2.9	2.9	NUM
admet-2387	100	87	min	min	NOUN
admet-2387	100	88	.	.	PROPN
admet-2387	100	89	mass	mass	PROPN
admet-2387	100	90	scanning	scanning	NOUN
admet-2387	100	91	was	be	AUX
admet-2387	100	92	performed	perform	VERB
admet-2387	100	93	on	on	ADP
admet-2387	100	94	the	the	DET
admet-2387	100	95	q	q	ADJ
admet-2387	100	96	-	-	ADJ
admet-2387	100	97	exactive	exactive	ADJ
admet-2387	100	98	plus	plus	CCONJ
admet-2387	100	99	using	use	VERB
admet-2387	100	100	positive	positive	ADJ
admet-2387	100	101	-	-	PUNCT
admet-2387	100	102	ion	ion	NOUN
admet-2387	100	103	full	full	ADJ
admet-2387	100	104	ms	ms	PROPN
admet-2387	100	105	/	/	SYM
admet-2387	100	106	dd	dd	NOUN
admet-2387	100	107	-	-	PUNCT
admet-2387	100	108	ms2	ms2	NOUN
admet-2387	100	109	mode	mode	NOUN
admet-2387	100	110	with	with	ADP
admet-2387	100	111	a	a	DET
admet-2387	100	112	range	range	NOUN
admet-2387	100	113	from	from	ADP
admet-2387	100	114	m	m	PROPN
admet-2387	100	115	/	/	SYM
admet-2387	100	116	z	z	PROPN
admet-2387	100	117	80	80	NUM
admet-2387	100	118	to	to	ADP
admet-2387	100	119	900	900	NUM
admet-2387	100	120	.	.	PUNCT
admet-2387	101	1	the	the	DET
admet-2387	101	2	collision	collision	NOUN
admet-2387	101	3	energy	energy	NOUN
admet-2387	101	4	was	be	AUX
admet-2387	101	5	set	set	VERB
admet-2387	101	6	at	at	ADP
admet-2387	101	7	30	30	NUM
admet-2387	101	8	,	,	PUNCT
admet-2387	101	9	40	40	NUM
admet-2387	101	10	and	and	CCONJ
admet-2387	101	11	50	50	NUM
admet-2387	101	12	ev	ev	NOUN
admet-2387	101	13	.	.	PUNCT
admet-2387	102	1	the	the	DET
admet-2387	102	2	mass	mass	ADJ
admet-2387	102	3	resolution	resolution	NOUN
admet-2387	102	4	was	be	AUX
admet-2387	102	5	set	set	VERB
admet-2387	102	6	as	as	ADP
admet-2387	102	7	70,000	70,000	NUM
admet-2387	102	8	for	for	ADP
admet-2387	102	9	full	full	ADJ
admet-2387	102	10	ms	ms	NOUN
admet-2387	102	11	,	,	PUNCT
admet-2387	102	12	and	and	CCONJ
admet-2387	102	13	17,500	17,500	NUM
admet-2387	102	14	for	for	ADP
admet-2387	102	15	dd	dd	ADJ
admet-2387	102	16	-	-	PUNCT
admet-2387	102	17	ms2	ms2	NOUN
admet-2387	102	18	scans	scan	NOUN
admet-2387	102	19	,	,	PUNCT
admet-2387	102	20	and	and	CCONJ
admet-2387	102	21	the	the	DET
admet-2387	102	22	mass	mass	NOUN
admet-2387	102	23	error	error	NOUN
admet-2387	102	24	limit	limit	NOUN
admet-2387	102	25	was	be	AUX
admet-2387	102	26	set	set	VERB
admet-2387	102	27	as	as	ADP
admet-2387	102	28	5.0	5.0	NUM
admet-2387	102	29	ppm	ppm	NOUN
admet-2387	102	30	.	.	PUNCT
admet-2387	103	1	admet	admet	PROPN
admet-2387	103	2	&	&	CCONJ
admet-2387	103	3	dmpk	dmpk	PROPN
admet-2387	103	4	12(6	12(6	NUM
admet-2387	103	5	)	)	PUNCT
admet-2387	103	6	(	(	PUNCT
admet-2387	103	7	2024	2024	NUM
admet-2387	103	8	)	)	PUNCT
admet-2387	103	9	943	943	NUM
admet-2387	103	10	-	-	SYM
admet-2387	103	11	955	955	NUM
admet-2387	103	12	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	103	13	and	and	CCONJ
admet-2387	103	14	metabolism	metabolism	NOUN
admet-2387	103	15	of	of	ADP
admet-2387	103	16	ketoconazole	ketoconazole	PROPN
admet-2387	103	17	doi	doi	PROPN
admet-2387	103	18	:	:	PUNCT
admet-2387	103	19	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	103	20	947	947	NUM
admet-2387	103	21	results	result	NOUN
admet-2387	103	22	and	and	CCONJ
admet-2387	103	23	discussion	discussion	NOUN
admet-2387	103	24	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	103	25	characteristics	characteristic	NOUN
admet-2387	103	26	as	as	SCONJ
admet-2387	103	27	shown	show	VERB
admet-2387	103	28	in	in	ADP
admet-2387	103	29	the	the	DET
admet-2387	103	30	left	left	ADJ
admet-2387	103	31	plot	plot	NOUN
admet-2387	103	32	in	in	ADP
admet-2387	103	33	figure	figure	NOUN
admet-2387	103	34	1	1	NUM
admet-2387	103	35	,	,	PUNCT
admet-2387	103	36	ketoconazole	ketoconazole	NOUN
admet-2387	103	37	concentrations	concentration	NOUN
admet-2387	103	38	were	be	AUX
admet-2387	103	39	measured	measure	VERB
admet-2387	103	40	in	in	ADP
admet-2387	103	41	plasma	plasma	NOUN
admet-2387	103	42	,	,	PUNCT
admet-2387	103	43	cornea	cornea	NOUN
admet-2387	103	44	,	,	PUNCT
admet-2387	103	45	retina	retina	NOUN
admet-2387	103	46	,	,	PUNCT
admet-2387	103	47	and	and	CCONJ
admet-2387	103	48	vitreous	vitreous	ADJ
admet-2387	103	49	humour	humour	NOUN
admet-2387	103	50	at	at	ADP
admet-2387	103	51	5	5	NUM
admet-2387	103	52	,	,	PUNCT
admet-2387	103	53	30	30	NUM
admet-2387	103	54	and	and	CCONJ
admet-2387	103	55	120	120	NUM
admet-2387	103	56	min	min	NOUN
admet-2387	103	57	after	after	ADP
admet-2387	103	58	topical	topical	ADJ
admet-2387	103	59	ocular	ocular	ADJ
admet-2387	103	60	administration	administration	NOUN
admet-2387	103	61	in	in	ADP
admet-2387	103	62	each	each	DET
admet-2387	103	63	eye	eye	NOUN
admet-2387	103	64	.	.	PUNCT
admet-2387	104	1	in	in	ADP
admet-2387	104	2	rat	rat	NOUN
admet-2387	104	3	plasma	plasma	NOUN
admet-2387	104	4	,	,	PUNCT
admet-2387	104	5	the	the	DET
admet-2387	104	6	mean	mean	ADJ
admet-2387	104	7	concentration	concentration	NOUN
admet-2387	104	8	was	be	AUX
admet-2387	104	9	determined	determine	VERB
admet-2387	104	10	to	to	PART
admet-2387	104	11	be	be	AUX
admet-2387	104	12	0.445	0.445	NUM
admet-2387	104	13	μg	μg	NOUN
admet-2387	104	14	/	/	SYM
admet-2387	104	15	ml	ml	X
admet-2387	104	16	at	at	ADP
admet-2387	104	17	5	5	NUM
admet-2387	104	18	min	min	NOUN
admet-2387	104	19	and	and	CCONJ
admet-2387	104	20	then	then	ADV
admet-2387	104	21	decreased	decrease	VERB
admet-2387	104	22	over	over	ADP
admet-2387	104	23	time	time	NOUN
admet-2387	104	24	.	.	PUNCT
admet-2387	105	1	in	in	ADP
admet-2387	105	2	rat	rat	PROPN
admet-2387	105	3	cornea	cornea	NOUN
admet-2387	105	4	,	,	PUNCT
admet-2387	105	5	the	the	DET
admet-2387	105	6	mean	mean	ADJ
admet-2387	105	7	concentration	concentration	NOUN
admet-2387	105	8	was	be	AUX
admet-2387	105	9	found	find	VERB
admet-2387	105	10	to	to	PART
admet-2387	105	11	be	be	AUX
admet-2387	105	12	extremely	extremely	ADV
admet-2387	105	13	high	high	ADJ
admet-2387	105	14	at	at	ADP
admet-2387	105	15	416	416	NUM
admet-2387	105	16	µg	µg	NOUN
admet-2387	105	17	/	/	SYM
admet-2387	105	18	g	g	NOUN
admet-2387	105	19	in	in	ADP
admet-2387	105	20	the	the	DET
admet-2387	105	21	left	left	ADJ
admet-2387	105	22	eye	eye	NOUN
admet-2387	105	23	and	and	CCONJ
admet-2387	105	24	430	430	NUM
admet-2387	105	25	µg	µg	NOUN
admet-2387	105	26	/	/	SYM
admet-2387	105	27	g	g	NOUN
admet-2387	105	28	in	in	ADP
admet-2387	105	29	the	the	DET
admet-2387	105	30	right	right	ADJ
admet-2387	105	31	eye	eye	NOUN
admet-2387	105	32	at	at	ADP
admet-2387	105	33	5	5	NUM
admet-2387	105	34	min	min	NOUN
admet-2387	105	35	post	post	NOUN
admet-2387	105	36	-	-	NOUN
admet-2387	105	37	dose	dose	NOUN
admet-2387	105	38	.	.	PUNCT
admet-2387	106	1	in	in	ADP
admet-2387	106	2	rat	rat	NOUN
admet-2387	106	3	retina	retina	NOUN
admet-2387	106	4	samples	sample	NOUN
admet-2387	106	5	,	,	PUNCT
admet-2387	106	6	the	the	DET
admet-2387	106	7	mean	mean	ADJ
admet-2387	106	8	concentration	concentration	NOUN
admet-2387	106	9	was	be	AUX
admet-2387	106	10	0.439	0.439	NUM
admet-2387	106	11	µg	µg	NOUN
admet-2387	106	12	/	/	SYM
admet-2387	106	13	g	g	NOUN
admet-2387	106	14	in	in	ADP
admet-2387	106	15	the	the	DET
admet-2387	106	16	left	left	ADJ
admet-2387	106	17	eye	eye	NOUN
admet-2387	106	18	and	and	CCONJ
admet-2387	106	19	0.552	0.552	NUM
admet-2387	106	20	µg	µg	NOUN
admet-2387	106	21	/	/	SYM
admet-2387	106	22	g	g	NOUN
admet-2387	106	23	in	in	ADP
admet-2387	106	24	the	the	DET
admet-2387	106	25	right	right	ADJ
admet-2387	106	26	eye	eye	NOUN
admet-2387	106	27	at	at	ADP
admet-2387	106	28	5	5	NUM
admet-2387	106	29	min	min	NOUN
admet-2387	106	30	post	post	ADJ
admet-2387	106	31	-	-	ADJ
admet-2387	106	32	dose	dose	ADJ
admet-2387	106	33	.	.	PUNCT
admet-2387	106	34	similar	similar	ADJ
admet-2387	106	35	to	to	ADP
admet-2387	106	36	rat	rat	NOUN
admet-2387	106	37	retina	retina	NOUN
admet-2387	106	38	,	,	PUNCT
admet-2387	106	39	the	the	DET
admet-2387	106	40	mean	mean	ADJ
admet-2387	106	41	concentration	concentration	NOUN
admet-2387	106	42	in	in	ADP
admet-2387	106	43	rat	rat	NOUN
admet-2387	106	44	vitreous	vitreous	ADJ
admet-2387	106	45	humour	humour	NOUN
admet-2387	106	46	was	be	AUX
admet-2387	106	47	1.12	1.12	NUM
admet-2387	106	48	µg	µg	NOUN
admet-2387	106	49	/	/	SYM
admet-2387	106	50	g	g	NOUN
admet-2387	106	51	in	in	ADP
admet-2387	106	52	the	the	DET
admet-2387	106	53	left	left	ADJ
admet-2387	106	54	eye	eye	NOUN
admet-2387	106	55	and	and	CCONJ
admet-2387	106	56	1.18	1.18	NUM
admet-2387	106	57	µg	µg	NOUN
admet-2387	106	58	/	/	SYM
admet-2387	106	59	g	g	NOUN
admet-2387	106	60	in	in	ADP
admet-2387	106	61	the	the	DET
admet-2387	106	62	right	right	ADJ
admet-2387	106	63	eye	eye	NOUN
admet-2387	106	64	at	at	ADP
admet-2387	106	65	5	5	NUM
admet-2387	106	66	min	min	NOUN
admet-2387	106	67	post	post	NOUN
admet-2387	106	68	-	-	NOUN
admet-2387	106	69	dose	dose	ADJ
admet-2387	106	70	.	.	PUNCT
admet-2387	107	1	the	the	DET
admet-2387	107	2	mean	mean	ADJ
admet-2387	107	3	ketoconazole	ketoconazole	NOUN
admet-2387	107	4	concentration	concentration	NOUN
admet-2387	107	5	in	in	ADP
admet-2387	107	6	each	each	DET
admet-2387	107	7	tissue	tissue	NOUN
admet-2387	107	8	decreased	decrease	VERB
admet-2387	107	9	from	from	ADP
admet-2387	107	10	5	5	NUM
admet-2387	107	11	to	to	PART
admet-2387	107	12	120	120	NUM
admet-2387	107	13	min	min	NOUN
admet-2387	107	14	.	.	PUNCT
admet-2387	108	1	the	the	DET
admet-2387	108	2	mean	mean	ADJ
admet-2387	108	3	concentration	concentration	NOUN
admet-2387	108	4	of	of	ADP
admet-2387	108	5	left	left	ADJ
admet-2387	108	6	and	and	CCONJ
admet-2387	108	7	right	right	ADJ
admet-2387	108	8	eye	eye	NOUN
admet-2387	108	9	tissue	tissue	NOUN
admet-2387	108	10	at	at	ADP
admet-2387	108	11	30	30	NUM
admet-2387	108	12	min	min	NOUN
admet-2387	108	13	post	post	NOUN
admet-2387	108	14	-	-	ADJ
admet-2387	108	15	dose	dose	ADJ
admet-2387	108	16	was	be	AUX
admet-2387	108	17	0.303	0.303	NUM
admet-2387	108	18	μg	μg	NOUN
admet-2387	108	19	/	/	SYM
admet-2387	108	20	ml	ml	X
admet-2387	108	21	in	in	ADP
admet-2387	108	22	plasma	plasma	NOUN
admet-2387	108	23	,	,	PUNCT
admet-2387	108	24	and	and	CCONJ
admet-2387	108	25	113	113	NUM
admet-2387	108	26	,	,	PUNCT
admet-2387	108	27	1.47	1.47	NUM
admet-2387	108	28	and	and	CCONJ
admet-2387	108	29	0.713	0.713	NUM
admet-2387	108	30	μg	μg	PROPN
admet-2387	108	31	/	/	SYM
admet-2387	108	32	g	g	PROPN
admet-2387	108	33	in	in	ADP
admet-2387	108	34	cornea	cornea	PROPN
admet-2387	108	35	,	,	PUNCT
admet-2387	108	36	retina	retina	NOUN
admet-2387	108	37	,	,	PUNCT
admet-2387	108	38	and	and	CCONJ
admet-2387	108	39	vitreous	vitreous	ADJ
admet-2387	108	40	humour	humour	NOUN
admet-2387	108	41	,	,	PUNCT
admet-2387	108	42	respectively	respectively	ADV
admet-2387	108	43	.	.	PUNCT
admet-2387	109	1	at	at	ADP
admet-2387	109	2	120	120	NUM
admet-2387	109	3	min	min	NOUN
admet-2387	109	4	post	post	NOUN
admet-2387	109	5	-	-	NOUN
admet-2387	109	6	dose	dose	ADJ
admet-2387	109	7	,	,	PUNCT
admet-2387	109	8	it	it	PRON
admet-2387	109	9	was	be	AUX
admet-2387	109	10	0.0384	0.0384	NUM
admet-2387	109	11	μg	μg	NOUN
admet-2387	109	12	/	/	SYM
admet-2387	109	13	ml	ml	X
admet-2387	109	14	in	in	ADP
admet-2387	109	15	plasma	plasma	NOUN
admet-2387	109	16	and	and	CCONJ
admet-2387	109	17	8.36	8.36	NUM
admet-2387	109	18	,	,	PUNCT
admet-2387	109	19	0.0944	0.0944	NUM
admet-2387	109	20	and	and	CCONJ
admet-2387	109	21	0.116	0.116	NUM
admet-2387	109	22	μg	μg	PROPN
admet-2387	109	23	/	/	SYM
admet-2387	109	24	g	g	PROPN
admet-2387	109	25	in	in	ADP
admet-2387	109	26	cornea	cornea	PROPN
admet-2387	109	27	,	,	PUNCT
admet-2387	109	28	retina	retina	NOUN
admet-2387	109	29	,	,	PUNCT
admet-2387	109	30	and	and	CCONJ
admet-2387	109	31	vitreous	vitreous	ADJ
admet-2387	109	32	humour	humour	NOUN
admet-2387	109	33	,	,	PUNCT
admet-2387	109	34	respectively	respectively	ADV
admet-2387	109	35	.	.	PUNCT
admet-2387	110	1	ketoconazole	ketoconazole	PROPN
admet-2387	110	2	exhibited	exhibit	VERB
admet-2387	110	3	higher	high	ADJ
admet-2387	110	4	concentrations	concentration	NOUN
admet-2387	110	5	in	in	ADP
admet-2387	110	6	the	the	DET
admet-2387	110	7	cornea	cornea	NOUN
admet-2387	110	8	,	,	PUNCT
admet-2387	110	9	retina	retina	NOUN
admet-2387	110	10	,	,	PUNCT
admet-2387	110	11	and	and	CCONJ
admet-2387	110	12	vitreous	vitreous	ADJ
admet-2387	110	13	humour	humour	NOUN
admet-2387	110	14	compared	compare	VERB
admet-2387	110	15	to	to	ADP
admet-2387	110	16	plasma	plasma	NOUN
admet-2387	110	17	following	follow	VERB
admet-2387	110	18	topical	topical	ADJ
admet-2387	110	19	ocular	ocular	ADJ
admet-2387	110	20	administration	administration	NOUN
admet-2387	110	21	.	.	PUNCT
admet-2387	111	1	as	as	SCONJ
admet-2387	111	2	illustrated	illustrate	VERB
admet-2387	111	3	in	in	ADP
admet-2387	111	4	figure	figure	NOUN
admet-2387	111	5	1b	1b	NUM
admet-2387	111	6	,	,	PUNCT
admet-2387	111	7	ketoconazole	ketoconazole	PROPN
admet-2387	111	8	showed	show	VERB
admet-2387	111	9	the	the	DET
admet-2387	111	10	highest	high	ADJ
admet-2387	111	11	tissue	tissue	NOUN
admet-2387	111	12	/	/	SYM
admet-2387	111	13	plasma	plasma	NOUN
admet-2387	111	14	ratios	ratio	NOUN
admet-2387	111	15	in	in	ADP
admet-2387	111	16	the	the	DET
admet-2387	111	17	cornea	cornea	NOUN
admet-2387	111	18	.	.	PUNCT
admet-2387	112	1	similarly	similarly	ADV
admet-2387	112	2	,	,	PUNCT
admet-2387	112	3	the	the	DET
admet-2387	112	4	retina	retina	NOUN
admet-2387	112	5	and	and	CCONJ
admet-2387	112	6	vitreous	vitreous	ADJ
admet-2387	112	7	humour	humour	NOUN
admet-2387	112	8	also	also	ADV
admet-2387	112	9	demonstrated	demonstrate	VERB
admet-2387	112	10	relatively	relatively	ADV
admet-2387	112	11	elevated	elevated	ADJ
admet-2387	112	12	tissue	tissue	NOUN
admet-2387	112	13	/	/	SYM
admet-2387	112	14	plasma	plasma	NOUN
admet-2387	112	15	ratios	ratio	NOUN
admet-2387	112	16	.	.	PUNCT
admet-2387	113	1	this	this	DET
admet-2387	113	2	finding	finding	NOUN
admet-2387	113	3	suggested	suggest	VERB
admet-2387	113	4	that	that	SCONJ
admet-2387	113	5	ketoconazole	ketoconazole	NOUN
admet-2387	113	6	was	be	AUX
admet-2387	113	7	readily	readily	ADV
admet-2387	113	8	accessible	accessible	ADJ
admet-2387	113	9	to	to	ADP
admet-2387	113	10	the	the	DET
admet-2387	113	11	cornea	cornea	NOUN
admet-2387	113	12	following	follow	VERB
admet-2387	113	13	ocular	ocular	ADJ
admet-2387	113	14	administration	administration	NOUN
admet-2387	113	15	.	.	PUNCT
admet-2387	114	1	in	in	ADP
admet-2387	114	2	an	an	DET
admet-2387	114	3	early	early	ADJ
admet-2387	114	4	study	study	NOUN
admet-2387	114	5	in	in	ADP
admet-2387	114	6	rabbits	rabbit	NOUN
admet-2387	114	7	[	[	X
admet-2387	114	8	36	36	NUM
admet-2387	114	9	]	]	X
admet-2387	114	10	,	,	PUNCT
admet-2387	114	11	a	a	DET
admet-2387	114	12	low	low	ADJ
admet-2387	114	13	ocular	ocular	ADJ
admet-2387	114	14	tissue	tissue	NOUN
admet-2387	114	15	/	/	SYM
admet-2387	114	16	serum	serum	NOUN
admet-2387	114	17	ratio	ratio	NOUN
admet-2387	114	18	was	be	AUX
admet-2387	114	19	observed	observe	VERB
admet-2387	114	20	following	follow	VERB
admet-2387	114	21	the	the	DET
admet-2387	114	22	oral	oral	ADJ
admet-2387	114	23	administration	administration	NOUN
admet-2387	114	24	of	of	ADP
admet-2387	114	25	ketoconazole	ketoconazole	PROPN
admet-2387	114	26	at	at	ADP
admet-2387	114	27	43.5	43.5	NUM
admet-2387	114	28	mg	mg	PROPN
admet-2387	114	29	/	/	SYM
admet-2387	114	30	kg	kg	PROPN
admet-2387	114	31	.	.	PUNCT
admet-2387	115	1	ketoconazole	ketoconazole	PROPN
admet-2387	115	2	serum	serum	NOUN
admet-2387	115	3	concentrations	concentration	NOUN
admet-2387	115	4	ranged	range	VERB
admet-2387	115	5	from	from	ADP
admet-2387	115	6	5.00	5.00	NUM
admet-2387	115	7	to	to	ADP
admet-2387	115	8	10.0	10.0	NUM
admet-2387	115	9	µg	µg	NOUN
admet-2387	115	10	/	/	SYM
admet-2387	115	11	ml	ml	NOUN
admet-2387	115	12	,	,	PUNCT
admet-2387	115	13	while	while	SCONJ
admet-2387	115	14	corneal	corneal	ADJ
admet-2387	115	15	and	and	CCONJ
admet-2387	115	16	vitreous	vitreous	ADJ
admet-2387	115	17	humour	humour	NOUN
admet-2387	115	18	concentrations	concentration	NOUN
admet-2387	115	19	were	be	AUX
admet-2387	115	20	detectable	detectable	ADJ
admet-2387	115	21	and	and	CCONJ
admet-2387	115	22	ranged	range	VERB
admet-2387	115	23	from	from	ADP
admet-2387	115	24	0	0	NUM
admet-2387	115	25	to	to	ADP
admet-2387	115	26	0.0400	0.0400	NUM
admet-2387	115	27	µg	µg	NOUN
admet-2387	115	28	/	/	SYM
admet-2387	115	29	ml	ml	NOUN
admet-2387	115	30	within	within	ADP
admet-2387	115	31	four	four	NUM
admet-2387	115	32	hours	hour	NOUN
admet-2387	115	33	post	post	ADJ
admet-2387	115	34	-	-	ADJ
admet-2387	115	35	dose	dose	ADJ
admet-2387	115	36	,	,	PUNCT
admet-2387	115	37	respectively	respectively	ADV
admet-2387	115	38	.	.	PUNCT
admet-2387	116	1	a	a	DET
admet-2387	116	2	different	different	ADJ
admet-2387	116	3	administration	administration	NOUN
admet-2387	116	4	route	route	NOUN
admet-2387	116	5	may	may	AUX
admet-2387	116	6	result	result	VERB
admet-2387	116	7	in	in	ADP
admet-2387	116	8	different	different	ADJ
admet-2387	116	9	ocular	ocular	ADJ
admet-2387	116	10	tissue	tissue	NOUN
admet-2387	116	11	/	/	SYM
admet-2387	116	12	plasma	plasma	NOUN
admet-2387	116	13	or	or	CCONJ
admet-2387	116	14	ocular	ocular	ADJ
admet-2387	116	15	tissue	tissue	NOUN
admet-2387	116	16	/	/	SYM
admet-2387	116	17	serum	serum	NOUN
admet-2387	116	18	ratios	ratio	NOUN
admet-2387	116	19	.	.	PUNCT
admet-2387	117	1	figure	figure	VERB
admet-2387	117	2	1	1	NUM
admet-2387	117	3	.	.	PUNCT
admet-2387	117	4	ketoconazole	ketoconazole	NOUN
admet-2387	117	5	concentration	concentration	NOUN
admet-2387	117	6	in	in	ADP
admet-2387	117	7	ocular	ocular	ADJ
admet-2387	117	8	tissue	tissue	NOUN
admet-2387	117	9	and	and	CCONJ
admet-2387	117	10	plasma	plasma	NOUN
admet-2387	117	11	(	(	PUNCT
admet-2387	117	12	a	a	NOUN
admet-2387	117	13	)	)	PUNCT
admet-2387	117	14	and	and	CCONJ
admet-2387	117	15	ratios	ratio	NOUN
admet-2387	117	16	of	of	ADP
admet-2387	117	17	ocular	ocular	ADJ
admet-2387	117	18	tissue	tissue	NOUN
admet-2387	117	19	to	to	ADP
admet-2387	117	20	plasma	plasma	NOUN
admet-2387	117	21	concentration	concentration	NOUN
admet-2387	117	22	(	(	PUNCT
admet-2387	117	23	b	b	NOUN
admet-2387	117	24	)	)	PUNCT
admet-2387	117	25	figure	figure	NOUN
admet-2387	117	26	2	2	NUM
admet-2387	117	27	.	.	X
admet-2387	117	28	collision	collision	NOUN
admet-2387	117	29	-	-	PUNCT
admet-2387	117	30	induced	induce	VERB
admet-2387	117	31	dissociation	dissociation	NOUN
admet-2387	117	32	spectrum	spectrum	NOUN
admet-2387	117	33	of	of	ADP
admet-2387	117	34	ketoconazole	ketoconazole	PROPN
admet-2387	117	35	(	(	PUNCT
admet-2387	117	36	ce	ce	PROPN
admet-2387	117	37	=	=	SYM
admet-2387	117	38	40	40	NUM
admet-2387	117	39	ev	ev	NOUN
admet-2387	117	40	)	)	PUNCT
admet-2387	117	41	a	a	DET
admet-2387	117	42	b	b	NOUN
admet-2387	117	43	c	c	NOUN
admet-2387	117	44	o	o	X
admet-2387	117	45	n	n	X
admet-2387	117	46	ce	ce	PROPN
admet-2387	117	47	n	n	CCONJ
admet-2387	117	48	tr	tr	VERB
admet-2387	117	49	at	at	ADP
admet-2387	117	50	io	io	PROPN
admet-2387	117	51	n	n	PRON
admet-2387	117	52	o	o	NOUN
admet-2387	117	53	f	f	X
admet-2387	117	54	ke	ke	PROPN
admet-2387	117	55	to	to	PART
admet-2387	117	56	co	co	VERB
admet-2387	117	57	n	n	PROPN
admet-2387	117	58	az	az	PROPN
admet-2387	117	59	o	o	PROPN
admet-2387	117	60	le	le	X
admet-2387	117	61	,	,	PUNCT
admet-2387	117	62	n	n	CCONJ
admet-2387	117	63	g	g	PROPN
admet-2387	117	64	/	/	SYM
admet-2387	117	65	m	m	PROPN
admet-2387	117	66	l	l	NOUN
admet-2387	117	67	r	r	NOUN
admet-2387	117	68	e	e	X
admet-2387	117	69	la	la	X
admet-2387	117	70	ti	ti	X
admet-2387	117	71	ve	ve	NOUN
admet-2387	117	72	a	a	DET
admet-2387	117	73	b	b	NOUN
admet-2387	117	74	u	u	NOUN
admet-2387	117	75	n	n	PROPN
admet-2387	117	76	d	d	PROPN
admet-2387	117	77	an	an	DET
admet-2387	117	78	ce	ce	PROPN
admet-2387	117	79	,	,	PUNCT
admet-2387	117	80	%	%	NOUN
admet-2387	117	81	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	117	82	j.	j.	PROPN
admet-2387	117	83	pu	pu	PROPN
admet-2387	117	84	et	et	PROPN
admet-2387	117	85	al	al	PROPN
admet-2387	117	86	.	.	PROPN
admet-2387	117	87	admet	admet	PROPN
admet-2387	117	88	&	&	CCONJ
admet-2387	117	89	dmpk	dmpk	PROPN
admet-2387	117	90	12(6	12(6	NUM
admet-2387	117	91	)	)	PUNCT
admet-2387	117	92	(	(	PUNCT
admet-2387	117	93	2024	2024	NUM
admet-2387	117	94	)	)	PUNCT
admet-2387	117	95	943	943	NUM
admet-2387	117	96	-	-	SYM
admet-2387	117	97	955	955	NUM
admet-2387	117	98	948	948	NUM
admet-2387	117	99	metabolites	metabolite	NOUN
admet-2387	117	100	identification	identification	NOUN
admet-2387	117	101	and	and	CCONJ
admet-2387	117	102	profiling	profiling	NOUN
admet-2387	117	103	in	in	ADP
admet-2387	117	104	figure	figure	NOUN
admet-2387	117	105	2	2	NUM
admet-2387	117	106	,	,	PUNCT
admet-2387	117	107	ketoconazole	ketoconazole	PROPN
admet-2387	117	108	showed	show	VERB
admet-2387	117	109	a	a	DET
admet-2387	117	110	protonated	protonate	VERB
admet-2387	117	111	molecular	molecular	ADJ
admet-2387	117	112	ion	ion	NOUN
admet-2387	118	1	[	[	X
admet-2387	118	2	m+h]+	m+h]+	NOUN
admet-2387	118	3	at	at	ADP
admet-2387	118	4	m	m	PROPN
admet-2387	118	5	/	/	SYM
admet-2387	118	6	z	z	PROPN
admet-2387	118	7	531.1551	531.1551	NUM
admet-2387	118	8	(	(	PUNCT
admet-2387	118	9	~1.9	~1.9	NUM
admet-2387	118	10	ppm	ppm	NOUN
admet-2387	118	11	)	)	PUNCT
admet-2387	118	12	.	.	PUNCT
admet-2387	119	1	the	the	DET
admet-2387	119	2	collision	collision	NOUN
admet-2387	119	3	-	-	PUNCT
admet-2387	119	4	induced	induce	VERB
admet-2387	119	5	dissociation	dissociation	NOUN
admet-2387	119	6	(	(	PUNCT
admet-2387	119	7	cid	cid	NOUN
admet-2387	119	8	)	)	PUNCT
admet-2387	119	9	product	product	NOUN
admet-2387	119	10	ion	ion	NOUN
admet-2387	119	11	spectrum	spectrum	NOUN
admet-2387	119	12	showed	show	VERB
admet-2387	119	13	characteristic	characteristic	ADJ
admet-2387	119	14	fragment	fragment	NOUN
admet-2387	119	15	ions	ion	NOUN
admet-2387	119	16	m	m	PROPN
admet-2387	119	17	/	/	SYM
admet-2387	119	18	z	z	PROPN
admet-2387	119	19	82.0530	82.0530	NUM
admet-2387	119	20	,	,	PUNCT
admet-2387	119	21	112.0759	112.0759	NUM
admet-2387	119	22	,	,	PUNCT
admet-2387	119	23	177.1020	177.1020	NUM
admet-2387	119	24	,	,	PUNCT
admet-2387	119	25	219.1126	219.1126	NUM
admet-2387	119	26	,	,	PUNCT
admet-2387	119	27	255.0083	255.0083	NUM
admet-2387	119	28	,	,	PUNCT
admet-2387	119	29	311.0338	311.0338	NUM
admet-2387	119	30	,	,	PUNCT
admet-2387	119	31	446.1033	446.1033	NUM
admet-2387	119	32	and	and	CCONJ
admet-2387	119	33	489.1448	489.1448	NUM
admet-2387	119	34	.	.	PUNCT
admet-2387	120	1	the	the	DET
admet-2387	120	2	lc	lc	PROPN
admet-2387	120	3	retention	retention	NOUN
admet-2387	120	4	time	time	NOUN
admet-2387	120	5	was	be	AUX
admet-2387	120	6	13.06	13.06	NUM
admet-2387	120	7	min	min	NOUN
admet-2387	120	8	.	.	PROPN
admet-2387	120	9	as	as	SCONJ
admet-2387	120	10	shown	show	VERB
admet-2387	120	11	in	in	ADP
admet-2387	120	12	figure	figure	NOUN
admet-2387	120	13	3	3	NUM
admet-2387	120	14	and	and	CCONJ
admet-2387	120	15	table	table	NOUN
admet-2387	120	16	1	1	NUM
admet-2387	120	17	,	,	PUNCT
admet-2387	120	18	a	a	DET
admet-2387	120	19	total	total	NOUN
admet-2387	120	20	of	of	ADP
admet-2387	120	21	thirteen	thirteen	NUM
admet-2387	120	22	metabolites	metabolite	NOUN
admet-2387	120	23	were	be	AUX
admet-2387	120	24	eluted	elute	VERB
admet-2387	120	25	from	from	ADP
admet-2387	120	26	8.91	8.91	NUM
admet-2387	120	27	to	to	ADP
admet-2387	120	28	16.34	16.34	NUM
admet-2387	120	29	min	min	NOUN
admet-2387	120	30	and	and	CCONJ
admet-2387	120	31	extracted	extract	VERB
admet-2387	120	32	within	within	ADP
admet-2387	120	33	a	a	DET
admet-2387	120	34	mass	mass	NOUN
admet-2387	120	35	error	error	NOUN
admet-2387	120	36	of	of	ADP
admet-2387	120	37	5	5	NUM
admet-2387	120	38	ppm	ppm	NOUN
admet-2387	120	39	,	,	PUNCT
admet-2387	120	40	most	most	ADJ
admet-2387	120	41	metabolites	metabolite	NOUN
admet-2387	120	42	were	be	AUX
admet-2387	120	43	eluted	elute	VERB
admet-2387	120	44	earlier	early	ADV
admet-2387	120	45	than	than	ADP
admet-2387	120	46	ketoconazole	ketoconazole	NOUN
admet-2387	120	47	and	and	CCONJ
admet-2387	120	48	turned	turn	VERB
admet-2387	120	49	out	out	ADP
admet-2387	120	50	to	to	PART
admet-2387	120	51	be	be	AUX
admet-2387	120	52	much	much	ADV
admet-2387	120	53	more	more	ADV
admet-2387	120	54	polar	polar	ADJ
admet-2387	120	55	compounds	compound	NOUN
admet-2387	120	56	.	.	PUNCT
admet-2387	121	1	figure	figure	NOUN
admet-2387	121	2	3	3	NUM
admet-2387	121	3	.	.	NUM
admet-2387	121	4	selected	select	VERB
admet-2387	121	5	ion	ion	NOUN
admet-2387	121	6	chromatogram	chromatogram	NOUN
admet-2387	121	7	of	of	ADP
admet-2387	121	8	ketoconazole	ketoconazole	NOUN
admet-2387	121	9	and	and	CCONJ
admet-2387	121	10	its	its	PRON
admet-2387	121	11	metabolites	metabolite	NOUN
admet-2387	121	12	several	several	ADJ
admet-2387	121	13	metabolites	metabolite	NOUN
admet-2387	121	14	were	be	AUX
admet-2387	121	15	identified	identify	VERB
admet-2387	121	16	by	by	ADP
admet-2387	121	17	the	the	DET
admet-2387	121	18	mass	mass	PROPN
admet-2387	121	19	defect	defect	NOUN
admet-2387	121	20	method	method	NOUN
admet-2387	121	21	based	base	VERB
admet-2387	121	22	on	on	ADP
admet-2387	121	23	the	the	DET
admet-2387	121	24	characteristic	characteristic	ADJ
admet-2387	121	25	fragment	fragment	NOUN
admet-2387	121	26	ions	ion	NOUN
admet-2387	121	27	compared	compare	VERB
admet-2387	121	28	with	with	ADP
admet-2387	121	29	ketoconazole	ketoconazole	NOUN
admet-2387	121	30	,	,	PUNCT
admet-2387	121	31	as	as	SCONJ
admet-2387	121	32	shown	show	VERB
admet-2387	121	33	in	in	ADP
admet-2387	121	34	figure	figure	NOUN
admet-2387	121	35	4	4	NUM
admet-2387	121	36	.	.	PUNCT
admet-2387	122	1	m1	m1	PROPN
admet-2387	122	2	showed	show	VERB
admet-2387	122	3	a	a	DET
admet-2387	122	4	protonated	protonate	VERB
admet-2387	122	5	molecular	molecular	ADJ
admet-2387	122	6	ion	ion	NOUN
admet-2387	122	7	at	at	ADP
admet-2387	122	8	m	m	PROPN
admet-2387	122	9	/	/	SYM
admet-2387	122	10	z	z	PROPN
admet-2387	122	11	547.1500	547.1500	NUM
admet-2387	122	12	,	,	PUNCT
admet-2387	122	13	its	its	PRON
admet-2387	122	14	characteristic	characteristic	ADJ
admet-2387	122	15	ions	ion	NOUN
admet-2387	122	16	were	be	AUX
admet-2387	122	17	m	m	PROPN
admet-2387	122	18	/	/	SYM
admet-2387	122	19	z	z	PROPN
admet-2387	122	20	255.0079	255.0079	NUM
admet-2387	122	21	,	,	PUNCT
admet-2387	122	22	471.1104	471.1104	NUM
admet-2387	122	23	and	and	CCONJ
admet-2387	122	24	505.1397	505.1397	NUM
admet-2387	122	25	.	.	PUNCT
admet-2387	123	1	m8	m8	PROPN
admet-2387	123	2	showed	show	VERB
admet-2387	123	3	a	a	DET
admet-2387	123	4	protonated	protonate	VERB
admet-2387	123	5	molecular	molecular	ADJ
admet-2387	123	6	ion	ion	NOUN
admet-2387	123	7	at	at	ADP
admet-2387	123	8	m	m	PROPN
admet-2387	123	9	/	/	SYM
admet-2387	123	10	z	z	PROPN
admet-2387	123	11	505.1496	505.1496	NUM
admet-2387	123	12	,	,	PUNCT
admet-2387	123	13	its	its	PRON
admet-2387	123	14	characteristic	characteristic	ADJ
admet-2387	123	15	ion	ion	NOUN
admet-2387	123	16	505.1415	505.1415	NOUN
admet-2387	123	17	.	.	PUNCT
admet-2387	124	1	m10	m10	PROPN
admet-2387	124	2	showed	show	VERB
admet-2387	124	3	a	a	DET
admet-2387	124	4	protonated	protonate	VERB
admet-2387	124	5	molecular	molecular	ADJ
admet-2387	124	6	ion	ion	NOUN
admet-2387	124	7	at	at	ADP
admet-2387	124	8	m	m	PROPN
admet-2387	124	9	/	/	SYM
admet-2387	124	10	z	z	PROPN
admet-2387	124	11	547.1409	547.1409	NUM
admet-2387	124	12	,	,	PUNCT
admet-2387	124	13	its	its	PRON
admet-2387	124	14	characteristic	characteristic	ADJ
admet-2387	124	15	ion	ion	NOUN
admet-2387	124	16	was	be	AUX
admet-2387	124	17	m	m	PROPN
admet-2387	124	18	/	/	SYM
admet-2387	124	19	z	z	PROPN
admet-2387	124	20	505.1351	505.1351	NUM
admet-2387	124	21	.	.	PUNCT
admet-2387	125	1	the	the	DET
admet-2387	125	2	addition	addition	NOUN
admet-2387	125	3	of	of	ADP
admet-2387	125	4	16	16	NUM
admet-2387	125	5	amu	amu	NOUN
admet-2387	125	6	to	to	ADP
admet-2387	125	7	parent	parent	NOUN
admet-2387	125	8	fragment	fragment	NOUN
admet-2387	125	9	ions	ion	NOUN
admet-2387	125	10	indicated	indicate	VERB
admet-2387	125	11	m1	m1	NOUN
admet-2387	125	12	,	,	PUNCT
admet-2387	125	13	m8	m8	PROPN
admet-2387	125	14	and	and	CCONJ
admet-2387	125	15	m10	m10	PROPN
admet-2387	125	16	were	be	AUX
admet-2387	125	17	mono	mono	NOUN
admet-2387	125	18	-	-	PUNCT
admet-2387	125	19	oxygenation	oxygenation	NOUN
admet-2387	125	20	metabolites	metabolite	NOUN
admet-2387	125	21	.	.	PUNCT
admet-2387	126	1	m4	m4	PROPN
admet-2387	126	2	showed	show	VERB
admet-2387	126	3	a	a	DET
admet-2387	126	4	protonated	protonate	VERB
admet-2387	126	5	molecular	molecular	ADJ
admet-2387	126	6	ion	ion	NOUN
admet-2387	126	7	at	at	ADP
admet-2387	126	8	m	m	PROPN
admet-2387	126	9	/	/	SYM
admet-2387	126	10	z	z	PROPN
admet-2387	126	11	489.1449	489.1449	NUM
admet-2387	126	12	,	,	PUNCT
admet-2387	126	13	its	its	PRON
admet-2387	126	14	cid	cid	NOUN
admet-2387	126	15	product	product	NOUN
admet-2387	126	16	ion	ion	NOUN
admet-2387	126	17	spectrum	spectrum	NOUN
admet-2387	126	18	displayed	display	VERB
admet-2387	126	19	fragment	fragment	ADJ
admet-2387	126	20	ions	ion	NOUN
admet-2387	126	21	at	at	ADP
admet-2387	126	22	m	m	PROPN
admet-2387	126	23	/	/	SYM
admet-2387	126	24	z	z	PROPN
admet-2387	126	25	82.0531	82.0531	NUM
admet-2387	126	26	,	,	PUNCT
admet-2387	126	27	136.0756	136.0756	NUM
admet-2387	126	28	,	,	PUNCT
admet-2387	126	29	178.1099	178.1099	NUM
admet-2387	126	30	and	and	CCONJ
admet-2387	126	31	446.1021	446.1021	NUM
admet-2387	126	32	,	,	PUNCT
admet-2387	126	33	the	the	DET
admet-2387	126	34	loss	loss	NOUN
admet-2387	126	35	of	of	ADP
admet-2387	126	36	42	42	NUM
admet-2387	126	37	amu	amu	NOUN
admet-2387	126	38	from	from	ADP
admet-2387	126	39	parent	parent	NOUN
admet-2387	126	40	ion	ion	NOUN
admet-2387	126	41	indicated	indicate	VERB
admet-2387	126	42	it	it	PRON
admet-2387	126	43	was	be	AUX
admet-2387	126	44	a	a	DET
admet-2387	126	45	hydrolysis	hydrolysis	NOUN
admet-2387	126	46	metabolite	metabolite	NOUN
admet-2387	126	47	,	,	PUNCT
admet-2387	126	48	also	also	ADV
admet-2387	126	49	called	call	VERB
admet-2387	126	50	as	as	ADP
admet-2387	126	51	a	a	DET
admet-2387	126	52	deacetyl	deacetyl	NOUN
admet-2387	126	53	-	-	PUNCT
admet-2387	126	54	ketoconazole	ketoconazole	NOUN
admet-2387	126	55	(	(	PUNCT
admet-2387	126	56	dak	dak	PROPN
admet-2387	126	57	)	)	PUNCT
admet-2387	126	58	.	.	PUNCT
admet-2387	127	1	m5	m5	NOUN
admet-2387	127	2	showed	show	VERB
admet-2387	127	3	a	a	DET
admet-2387	127	4	protonated	protonate	VERB
admet-2387	127	5	molecular	molecular	ADJ
admet-2387	127	6	ion	ion	NOUN
admet-2387	127	7	at	at	ADP
admet-2387	127	8	m	m	PROPN
admet-2387	127	9	/	/	SYM
admet-2387	127	10	z	z	PROPN
admet-2387	127	11	505.1399	505.1399	NUM
admet-2387	127	12	,	,	PUNCT
admet-2387	127	13	its	its	PRON
admet-2387	127	14	cid	cid	NOUN
admet-2387	127	15	product	product	NOUN
admet-2387	127	16	ion	ion	NOUN
admet-2387	127	17	spectrum	spectrum	NOUN
admet-2387	127	18	displayed	display	VERB
admet-2387	127	19	fragment	fragment	ADJ
admet-2387	127	20	ions	ion	NOUN
admet-2387	127	21	at	at	ADP
admet-2387	127	22	m	m	PROPN
admet-2387	127	23	/	/	SYM
admet-2387	127	24	z	z	PROPN
admet-2387	127	25	255.0083	255.0083	NUM
admet-2387	127	26	,	,	PUNCT
admet-2387	127	27	267.0082	267.0082	NUM
admet-2387	127	28	and	and	CCONJ
admet-2387	127	29	420.0872	420.0872	NUM
admet-2387	127	30	,	,	PUNCT
admet-2387	127	31	the	the	DET
admet-2387	127	32	addition	addition	NOUN
admet-2387	127	33	of	of	ADP
admet-2387	127	34	16	16	NUM
admet-2387	127	35	amu	amu	NOUN
admet-2387	127	36	to	to	ADP
admet-2387	127	37	m4	m4	PROPN
admet-2387	127	38	indicated	indicate	VERB
admet-2387	127	39	it	it	PRON
admet-2387	127	40	was	be	AUX
admet-2387	127	41	a	a	DET
admet-2387	127	42	metabolite	metabolite	NOUN
admet-2387	127	43	of	of	ADP
admet-2387	127	44	hydrolysis	hydrolysis	NOUN
admet-2387	127	45	and	and	CCONJ
admet-2387	127	46	mono	mono	NOUN
admet-2387	127	47	-	-	PUNCT
admet-2387	127	48	oxygenation	oxygenation	NOUN
admet-2387	127	49	.	.	PUNCT
admet-2387	128	1	m11	m11	PROPN
admet-2387	128	2	exhibited	exhibit	VERB
admet-2387	128	3	a	a	DET
admet-2387	128	4	protonated	protonate	VERB
admet-2387	128	5	molecular	molecular	ADJ
admet-2387	128	6	ion	ion	NOUN
admet-2387	128	7	at	at	ADP
admet-2387	128	8	m	m	PROPN
admet-2387	128	9	/	/	SYM
admet-2387	128	10	z	z	PROPN
admet-2387	128	11	529.1390	529.1390	NUM
admet-2387	128	12	,	,	PUNCT
admet-2387	128	13	its	its	PRON
admet-2387	128	14	cid	cid	NOUN
admet-2387	128	15	product	product	NOUN
admet-2387	128	16	ion	ion	NOUN
admet-2387	128	17	spectrum	spectrum	NOUN
admet-2387	128	18	displayed	display	VERB
admet-2387	128	19	fragment	fragment	ADJ
admet-2387	128	20	ions	ion	NOUN
admet-2387	128	21	at	at	ADP
admet-2387	128	22	m	m	PROPN
admet-2387	128	23	/	/	SYM
admet-2387	128	24	z	z	PROPN
admet-2387	128	25	175.0864	175.0864	NUM
admet-2387	128	26	,	,	PUNCT
admet-2387	128	27	218.1046	218.1046	NUM
admet-2387	128	28	,	,	PUNCT
admet-2387	128	29	255.0091	255.0091	NUM
admet-2387	128	30	and	and	CCONJ
admet-2387	128	31	487.1302	487.1302	NUM
admet-2387	128	32	,	,	PUNCT
admet-2387	128	33	the	the	DET
admet-2387	128	34	loss	loss	NOUN
admet-2387	128	35	of	of	ADP
admet-2387	128	36	2	2	NUM
admet-2387	128	37	amu	amu	NOUN
admet-2387	128	38	from	from	ADP
admet-2387	128	39	parent	parent	NOUN
admet-2387	128	40	fragment	fragment	NOUN
admet-2387	128	41	ions	ion	NOUN
admet-2387	128	42	indicated	indicate	VERB
admet-2387	128	43	it	it	PRON
admet-2387	128	44	was	be	AUX
admet-2387	128	45	a	a	DET
admet-2387	128	46	dehydrogenation	dehydrogenation	NOUN
admet-2387	128	47	metabolite	metabolite	NOUN
admet-2387	128	48	.	.	PUNCT
admet-2387	129	1	r	r	NOUN
admet-2387	129	2	el	el	PROPN
admet-2387	129	3	at	at	ADP
admet-2387	129	4	iv	iv	NUM
admet-2387	129	5	e	e	PROPN
admet-2387	129	6	ab	ab	PROPN
admet-2387	129	7	u	u	PROPN
admet-2387	129	8	n	n	PROPN
admet-2387	129	9	d	d	PROPN
admet-2387	129	10	an	an	DET
admet-2387	129	11	ce	ce	PROPN
admet-2387	129	12	,	,	PUNCT
admet-2387	129	13	%	%	INTJ
admet-2387	129	14	r	r	NOUN
admet-2387	129	15	el	el	PROPN
admet-2387	129	16	at	at	ADP
admet-2387	129	17	iv	iv	NUM
admet-2387	129	18	e	e	PROPN
admet-2387	129	19	ab	ab	PROPN
admet-2387	129	20	u	u	PROPN
admet-2387	130	1	n	n	PROPN
admet-2387	130	2	d	d	PROPN
admet-2387	130	3	an	an	DET
admet-2387	130	4	ce	ce	PROPN
admet-2387	130	5	,	,	PUNCT
admet-2387	130	6	%	%	INTJ
admet-2387	130	7	r	r	NOUN
admet-2387	130	8	el	el	PROPN
admet-2387	130	9	at	at	ADP
admet-2387	130	10	iv	iv	NUM
admet-2387	130	11	e	e	PROPN
admet-2387	130	12	ab	ab	PROPN
admet-2387	130	13	u	u	PROPN
admet-2387	130	14	n	n	PROPN
admet-2387	130	15	d	d	PROPN
admet-2387	130	16	an	an	DET
admet-2387	130	17	ce	ce	PROPN
admet-2387	130	18	,	,	PUNCT
admet-2387	130	19	%	%	INTJ
admet-2387	130	20	r	r	NOUN
admet-2387	130	21	el	el	PROPN
admet-2387	130	22	at	at	ADP
admet-2387	130	23	iv	iv	NUM
admet-2387	130	24	e	e	PROPN
admet-2387	130	25	ab	ab	PROPN
admet-2387	130	26	u	u	PROPN
admet-2387	131	1	n	n	PROPN
admet-2387	131	2	d	d	PROPN
admet-2387	131	3	an	an	DET
admet-2387	131	4	ce	ce	PROPN
admet-2387	131	5	,	,	PUNCT
admet-2387	131	6	%	%	INTJ
admet-2387	131	7	admet	admet	PROPN
admet-2387	131	8	&	&	CCONJ
admet-2387	131	9	dmpk	dmpk	PROPN
admet-2387	131	10	12(6	12(6	NUM
admet-2387	131	11	)	)	PUNCT
admet-2387	131	12	(	(	PUNCT
admet-2387	131	13	2024	2024	NUM
admet-2387	131	14	)	)	PUNCT
admet-2387	131	15	943	943	NUM
admet-2387	131	16	-	-	SYM
admet-2387	131	17	955	955	NUM
admet-2387	131	18	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	131	19	and	and	CCONJ
admet-2387	131	20	metabolism	metabolism	NOUN
admet-2387	131	21	of	of	ADP
admet-2387	131	22	ketoconazole	ketoconazole	PROPN
admet-2387	131	23	doi	doi	PROPN
admet-2387	131	24	:	:	PUNCT
admet-2387	131	25	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	131	26	949	949	NUM
admet-2387	131	27	figure	figure	NOUN
admet-2387	131	28	4	4	NUM
admet-2387	131	29	.	.	PUNCT
admet-2387	132	1	ms	ms	PROPN
admet-2387	132	2	/	/	SYM
admet-2387	132	3	ms	ms	PROPN
admet-2387	132	4	spectra	spectra	NOUN
admet-2387	132	5	of	of	ADP
admet-2387	132	6	metabolites	metabolite	NOUN
admet-2387	132	7	of	of	ADP
admet-2387	132	8	ketoconazole	ketoconazole	NOUN
admet-2387	132	9	in	in	ADP
admet-2387	132	10	rat	rat	NOUN
admet-2387	132	11	cornea	cornea	NOUN
admet-2387	132	12	,	,	PUNCT
admet-2387	132	13	retina	retina	NOUN
admet-2387	132	14	,	,	PUNCT
admet-2387	132	15	vitreous	vitreous	ADJ
admet-2387	132	16	humour	humour	NOUN
admet-2387	132	17	and	and	CCONJ
admet-2387	132	18	plasma	plasma	NOUN
admet-2387	132	19	m7	m7	PROPN
admet-2387	132	20	showed	show	VERB
admet-2387	132	21	a	a	DET
admet-2387	132	22	protonated	protonate	VERB
admet-2387	132	23	molecular	molecular	ADJ
admet-2387	132	24	ion	ion	NOUN
admet-2387	132	25	at	at	ADP
admet-2387	132	26	m	m	PROPN
admet-2387	132	27	/	/	SYM
admet-2387	132	28	z	z	PROPN
admet-2387	132	29	545.1343	545.1343	NUM
admet-2387	132	30	,	,	PUNCT
admet-2387	132	31	its	its	PRON
admet-2387	132	32	cid	cid	NOUN
admet-2387	132	33	product	product	NOUN
admet-2387	132	34	ion	ion	NOUN
admet-2387	132	35	spectrum	spectrum	NOUN
admet-2387	132	36	displayed	display	VERB
admet-2387	132	37	fragment	fragment	ADJ
admet-2387	132	38	ions	ion	NOUN
admet-2387	132	39	at	at	ADP
admet-2387	132	40	m	m	PROPN
admet-2387	132	41	/	/	SYM
admet-2387	132	42	z	z	PROPN
admet-2387	132	43	255.0082	255.0082	NUM
admet-2387	132	44	,	,	PUNCT
admet-2387	132	45	421.0720	421.0720	NUM
admet-2387	132	46	and	and	CCONJ
admet-2387	132	47	503.1211	503.1211	NUM
admet-2387	132	48	.	.	PUNCT
admet-2387	133	1	m9	m9	PROPN
admet-2387	133	2	showed	show	VERB
admet-2387	133	3	a	a	DET
admet-2387	133	4	protonated	protonate	VERB
admet-2387	133	5	molecular	molecular	ADJ
admet-2387	133	6	ion	ion	NOUN
admet-2387	133	7	at	at	ADP
admet-2387	133	8	m	m	PROPN
admet-2387	133	9	/	/	SYM
admet-2387	133	10	z	z	PROPN
admet-2387	133	11	545.1337	545.1337	NUM
admet-2387	133	12	,	,	PUNCT
admet-2387	133	13	its	its	PRON
admet-2387	133	14	cid	cid	NOUN
admet-2387	133	15	product	product	NOUN
admet-2387	133	16	ion	ion	NOUN
admet-2387	133	17	spectrum	spectrum	NOUN
admet-2387	133	18	displayed	display	VERB
admet-2387	133	19	fragment	fragment	ADJ
admet-2387	133	20	ions	ion	NOUN
admet-2387	133	21	at	at	ADP
admet-2387	133	22	m	m	PROPN
admet-2387	133	23	/	/	SYM
admet-2387	133	24	z	z	PROPN
admet-2387	133	25	255.0081	255.0081	NUM
admet-2387	133	26	,	,	PUNCT
admet-2387	133	27	329.0440	329.0440	NUM
admet-2387	133	28	,	,	PUNCT
admet-2387	133	29	487.0919	487.0919	NUM
admet-2387	133	30	and	and	CCONJ
admet-2387	133	31	503.1187	503.1187	NUM
admet-2387	133	32	m12	m12	NOUN
admet-2387	133	33	showed	show	VERB
admet-2387	133	34	a	a	DET
admet-2387	133	35	protonated	protonate	VERB
admet-2387	133	36	molecular	molecular	ADJ
admet-2387	133	37	ion	ion	NOUN
admet-2387	133	38	at	at	ADP
admet-2387	133	39	m	m	PROPN
admet-2387	133	40	/	/	SYM
admet-2387	133	41	z	z	PROPN
admet-2387	133	42	545.1343	545.1343	NUM
admet-2387	133	43	,	,	PUNCT
admet-2387	133	44	its	its	PRON
admet-2387	133	45	cid	cid	NOUN
admet-2387	133	46	product	product	NOUN
admet-2387	133	47	ion	ion	NOUN
admet-2387	133	48	spectrum	spectrum	NOUN
admet-2387	133	49	displayed	display	VERB
admet-2387	133	50	fragment	fragment	ADJ
admet-2387	133	51	ions	ion	NOUN
admet-2387	133	52	r	r	NOUN
admet-2387	133	53	el	el	PROPN
admet-2387	133	54	at	at	ADP
admet-2387	133	55	iv	iv	NUM
admet-2387	133	56	e	e	PROPN
admet-2387	133	57	ab	ab	PROPN
admet-2387	133	58	u	u	PROPN
admet-2387	133	59	n	n	PROPN
admet-2387	133	60	d	d	PROPN
admet-2387	133	61	an	an	DET
admet-2387	133	62	ce	ce	PROPN
admet-2387	133	63	,	,	PUNCT
admet-2387	133	64	%	%	INTJ
admet-2387	133	65	r	r	NOUN
admet-2387	133	66	el	el	PROPN
admet-2387	133	67	at	at	ADP
admet-2387	133	68	iv	iv	NUM
admet-2387	133	69	e	e	PROPN
admet-2387	133	70	ab	ab	PROPN
admet-2387	133	71	u	u	PROPN
admet-2387	133	72	n	n	PROPN
admet-2387	133	73	d	d	PROPN
admet-2387	133	74	an	an	DET
admet-2387	133	75	ce	ce	PROPN
admet-2387	133	76	,	,	PUNCT
admet-2387	134	1	%	%	INTJ
admet-2387	134	2	r	r	NOUN
admet-2387	134	3	el	el	PROPN
admet-2387	134	4	at	at	ADP
admet-2387	134	5	iv	iv	NUM
admet-2387	134	6	e	e	PROPN
admet-2387	134	7	ab	ab	PROPN
admet-2387	134	8	u	u	PROPN
admet-2387	134	9	n	n	PROPN
admet-2387	134	10	d	d	PROPN
admet-2387	134	11	an	an	DET
admet-2387	134	12	ce	ce	PROPN
admet-2387	134	13	,	,	PUNCT
admet-2387	134	14	%	%	INTJ
admet-2387	134	15	r	r	NOUN
admet-2387	134	16	el	el	PROPN
admet-2387	134	17	at	at	ADP
admet-2387	134	18	iv	iv	NUM
admet-2387	134	19	e	e	PROPN
admet-2387	134	20	ab	ab	PROPN
admet-2387	134	21	u	u	PROPN
admet-2387	135	1	n	n	PROPN
admet-2387	135	2	d	d	PROPN
admet-2387	135	3	an	an	DET
admet-2387	135	4	ce	ce	PROPN
admet-2387	135	5	,	,	PUNCT
admet-2387	135	6	%	%	INTJ
admet-2387	135	7	r	r	NOUN
admet-2387	135	8	el	el	PROPN
admet-2387	135	9	at	at	ADP
admet-2387	135	10	iv	iv	NUM
admet-2387	135	11	e	e	PROPN
admet-2387	135	12	ab	ab	PROPN
admet-2387	135	13	u	u	PROPN
admet-2387	135	14	n	n	PROPN
admet-2387	135	15	d	d	PROPN
admet-2387	135	16	an	an	DET
admet-2387	135	17	ce	ce	PROPN
admet-2387	135	18	,	,	PUNCT
admet-2387	135	19	%	%	INTJ
admet-2387	135	20	r	r	NOUN
admet-2387	135	21	el	el	PROPN
admet-2387	135	22	at	at	ADP
admet-2387	135	23	iv	iv	NUM
admet-2387	135	24	e	e	PROPN
admet-2387	135	25	ab	ab	PROPN
admet-2387	135	26	u	u	PROPN
admet-2387	136	1	n	n	PROPN
admet-2387	136	2	d	d	PROPN
admet-2387	136	3	an	an	DET
admet-2387	136	4	ce	ce	PROPN
admet-2387	136	5	,	,	PUNCT
admet-2387	136	6	%	%	INTJ
admet-2387	136	7	r	r	NOUN
admet-2387	136	8	el	el	PROPN
admet-2387	136	9	at	at	ADP
admet-2387	136	10	iv	iv	NUM
admet-2387	136	11	e	e	PROPN
admet-2387	136	12	ab	ab	PROPN
admet-2387	136	13	u	u	PROPN
admet-2387	136	14	n	n	PROPN
admet-2387	136	15	d	d	PROPN
admet-2387	136	16	an	an	DET
admet-2387	136	17	ce	ce	PROPN
admet-2387	136	18	,	,	PUNCT
admet-2387	136	19	%	%	INTJ
admet-2387	136	20	r	r	NOUN
admet-2387	136	21	el	el	PROPN
admet-2387	136	22	at	at	ADP
admet-2387	136	23	iv	iv	NUM
admet-2387	136	24	e	e	PROPN
admet-2387	136	25	ab	ab	PROPN
admet-2387	136	26	u	u	PROPN
admet-2387	137	1	n	n	PROPN
admet-2387	137	2	d	d	PROPN
admet-2387	137	3	an	an	DET
admet-2387	137	4	ce	ce	PROPN
admet-2387	137	5	,	,	PUNCT
admet-2387	137	6	%	%	INTJ
admet-2387	137	7	r	r	NOUN
admet-2387	137	8	el	el	PROPN
admet-2387	137	9	at	at	ADP
admet-2387	137	10	iv	iv	NUM
admet-2387	137	11	e	e	PROPN
admet-2387	137	12	ab	ab	PROPN
admet-2387	137	13	u	u	PROPN
admet-2387	137	14	n	n	PROPN
admet-2387	137	15	d	d	PROPN
admet-2387	137	16	an	an	DET
admet-2387	137	17	ce	ce	PROPN
admet-2387	137	18	,	,	PUNCT
admet-2387	137	19	%	%	INTJ
admet-2387	137	20	r	r	NOUN
admet-2387	137	21	el	el	PROPN
admet-2387	137	22	at	at	ADP
admet-2387	137	23	iv	iv	NUM
admet-2387	137	24	e	e	PROPN
admet-2387	137	25	ab	ab	PROPN
admet-2387	137	26	u	u	PROPN
admet-2387	138	1	n	n	PROPN
admet-2387	138	2	d	d	PROPN
admet-2387	138	3	an	an	DET
admet-2387	138	4	ce	ce	PROPN
admet-2387	138	5	,	,	PUNCT
admet-2387	138	6	%	%	INTJ
admet-2387	138	7	r	r	NOUN
admet-2387	138	8	el	el	PROPN
admet-2387	138	9	at	at	ADP
admet-2387	138	10	iv	iv	NUM
admet-2387	138	11	e	e	PROPN
admet-2387	138	12	ab	ab	PROPN
admet-2387	138	13	u	u	PROPN
admet-2387	138	14	n	n	PROPN
admet-2387	138	15	d	d	PROPN
admet-2387	138	16	an	an	DET
admet-2387	138	17	ce	ce	PROPN
admet-2387	138	18	,	,	PUNCT
admet-2387	138	19	%	%	INTJ
admet-2387	138	20	r	r	NOUN
admet-2387	138	21	el	el	PROPN
admet-2387	138	22	at	at	ADP
admet-2387	138	23	iv	iv	NUM
admet-2387	138	24	e	e	PROPN
admet-2387	138	25	ab	ab	PROPN
admet-2387	138	26	u	u	PROPN
admet-2387	139	1	n	n	PROPN
admet-2387	139	2	d	d	PROPN
admet-2387	139	3	an	an	DET
admet-2387	139	4	ce	ce	PROPN
admet-2387	139	5	,	,	PUNCT
admet-2387	139	6	%	%	INTJ
admet-2387	139	7	r	r	NOUN
admet-2387	139	8	el	el	PROPN
admet-2387	139	9	at	at	ADP
admet-2387	139	10	iv	iv	NUM
admet-2387	139	11	e	e	PROPN
admet-2387	139	12	ab	ab	PROPN
admet-2387	139	13	u	u	PROPN
admet-2387	139	14	n	n	PROPN
admet-2387	139	15	d	d	PROPN
admet-2387	139	16	an	an	DET
admet-2387	139	17	ce	ce	PROPN
admet-2387	139	18	,	,	PUNCT
admet-2387	139	19	%	%	INTJ
admet-2387	139	20	r	r	NOUN
admet-2387	139	21	el	el	PROPN
admet-2387	139	22	at	at	ADP
admet-2387	139	23	iv	iv	NUM
admet-2387	139	24	e	e	PROPN
admet-2387	139	25	ab	ab	PROPN
admet-2387	139	26	u	u	PROPN
admet-2387	140	1	n	n	PROPN
admet-2387	140	2	d	d	PROPN
admet-2387	140	3	an	an	DET
admet-2387	140	4	ce	ce	PROPN
admet-2387	140	5	,	,	PUNCT
admet-2387	140	6	%	%	NOUN
admet-2387	140	7	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	140	8	j.	j.	PROPN
admet-2387	140	9	pu	pu	PROPN
admet-2387	140	10	et	et	PROPN
admet-2387	140	11	al	al	PROPN
admet-2387	140	12	.	.	PROPN
admet-2387	140	13	admet	admet	PROPN
admet-2387	140	14	&	&	CCONJ
admet-2387	140	15	dmpk	dmpk	PROPN
admet-2387	140	16	12(6	12(6	NUM
admet-2387	140	17	)	)	PUNCT
admet-2387	140	18	(	(	PUNCT
admet-2387	140	19	2024	2024	NUM
admet-2387	140	20	)	)	PUNCT
admet-2387	140	21	943	943	NUM
admet-2387	140	22	-	-	SYM
admet-2387	140	23	955	955	NUM
admet-2387	140	24	950	950	NUM
admet-2387	140	25	at	at	ADP
admet-2387	140	26	m	m	PROPN
admet-2387	140	27	/	/	SYM
admet-2387	140	28	z	z	PROPN
admet-2387	140	29	244.0051	244.0051	NUM
admet-2387	140	30	,	,	PUNCT
admet-2387	140	31	311.0325	311.0325	NUM
admet-2387	140	32	and	and	CCONJ
admet-2387	140	33	503.1207	503.1207	NOUN
admet-2387	140	34	.	.	PUNCT
admet-2387	141	1	m13	m13	NOUN
admet-2387	141	2	exhibited	exhibit	VERB
admet-2387	141	3	a	a	DET
admet-2387	141	4	protonated	protonate	VERB
admet-2387	141	5	molecular	molecular	ADJ
admet-2387	141	6	ion	ion	NOUN
admet-2387	141	7	at	at	ADP
admet-2387	141	8	m	m	PROPN
admet-2387	141	9	/	/	SYM
admet-2387	141	10	z	z	PROPN
admet-2387	141	11	545.1345	545.1345	NUM
admet-2387	141	12	,	,	PUNCT
admet-2387	141	13	its	its	PRON
admet-2387	141	14	cid	cid	NOUN
admet-2387	141	15	product	product	NOUN
admet-2387	141	16	ion	ion	NOUN
admet-2387	141	17	spectrum	spectrum	NOUN
admet-2387	141	18	displayed	display	VERB
admet-2387	141	19	fragment	fragment	ADJ
admet-2387	141	20	ions	ion	NOUN
admet-2387	141	21	at	at	ADP
admet-2387	141	22	m	m	PROPN
admet-2387	141	23	/	/	SYM
admet-2387	141	24	z	z	PROPN
admet-2387	141	25	244.0050	244.0050	NUM
admet-2387	141	26	,	,	PUNCT
admet-2387	141	27	311.0336	311.0336	NUM
admet-2387	141	28	and	and	CCONJ
admet-2387	141	29	503.1237	503.1237	NUM
admet-2387	141	30	.	.	PUNCT
admet-2387	142	1	the	the	DET
admet-2387	142	2	addition	addition	NOUN
admet-2387	142	3	of	of	ADP
admet-2387	142	4	14	14	NUM
admet-2387	142	5	amu	amu	NOUN
admet-2387	142	6	to	to	ADP
admet-2387	142	7	parent	parent	NOUN
admet-2387	142	8	fragment	fragment	NOUN
admet-2387	142	9	ions	ion	NOUN
admet-2387	142	10	indicated	indicate	VERB
admet-2387	142	11	that	that	SCONJ
admet-2387	142	12	m7	m7	PROPN
admet-2387	142	13	,	,	PUNCT
admet-2387	142	14	m9	m9	PROPN
admet-2387	142	15	,	,	PUNCT
admet-2387	142	16	m12	m12	PROPN
admet-2387	142	17	,	,	PUNCT
admet-2387	142	18	and	and	CCONJ
admet-2387	142	19	m13	m13	NOUN
admet-2387	142	20	were	be	AUX
admet-2387	142	21	metabolites	metabolite	NOUN
admet-2387	142	22	of	of	ADP
admet-2387	142	23	mono	mono	NOUN
admet-2387	142	24	-	-	PUNCT
admet-2387	142	25	oxygenation	oxygenation	NOUN
admet-2387	142	26	and	and	CCONJ
admet-2387	142	27	dehydrogenation	dehydrogenation	NOUN
admet-2387	142	28	.	.	PUNCT
admet-2387	143	1	the	the	DET
admet-2387	143	2	other	other	ADJ
admet-2387	143	3	metabolites	metabolite	NOUN
admet-2387	143	4	were	be	AUX
admet-2387	143	5	elucidated	elucidate	VERB
admet-2387	143	6	according	accord	VERB
admet-2387	143	7	to	to	ADP
admet-2387	143	8	their	their	PRON
admet-2387	143	9	characteristic	characteristic	ADJ
admet-2387	143	10	fragment	fragment	NOUN
admet-2387	143	11	ions	ion	NOUN
admet-2387	143	12	and	and	CCONJ
admet-2387	143	13	m	m	PROPN
admet-2387	143	14	/	/	SYM
admet-2387	143	15	z	z	NOUN
admet-2387	143	16	accuracy	accuracy	NOUN
admet-2387	143	17	.	.	PUNCT
admet-2387	144	1	m2	m2	PROPN
admet-2387	144	2	showed	show	VERB
admet-2387	144	3	a	a	DET
admet-2387	144	4	protonated	protonate	VERB
admet-2387	144	5	molecular	molecular	ADJ
admet-2387	144	6	ion	ion	NOUN
admet-2387	144	7	at	at	ADP
admet-2387	144	8	m	m	PROPN
admet-2387	144	9	/	/	SYM
admet-2387	144	10	z	z	NOUN
admet-2387	144	11	329.0446	329.0446	NUM
admet-2387	144	12	,	,	PUNCT
admet-2387	144	13	its	its	PRON
admet-2387	144	14	cid	cid	NOUN
admet-2387	144	15	product	product	NOUN
admet-2387	144	16	ions	ion	NOUN
admet-2387	144	17	were	be	AUX
admet-2387	144	18	m	m	PROPN
admet-2387	144	19	/	/	SYM
admet-2387	144	20	z	z	NOUN
admet-2387	144	21	158.9761	158.9761	NUM
admet-2387	144	22	and	and	CCONJ
admet-2387	144	23	274.9870	274.9870	NUM
admet-2387	144	24	,	,	PUNCT
admet-2387	144	25	the	the	DET
admet-2387	144	26	loss	loss	NOUN
admet-2387	144	27	of	of	ADP
admet-2387	144	28	202	202	NUM
admet-2387	144	29	amu	amu	NOUN
admet-2387	144	30	from	from	ADP
admet-2387	144	31	parent	parent	NOUN
admet-2387	144	32	ion	ion	NOUN
admet-2387	144	33	indicated	indicate	VERB
admet-2387	144	34	it	it	PRON
admet-2387	144	35	was	be	AUX
admet-2387	144	36	a	a	DET
admet-2387	144	37	metabolite	metabolite	NOUN
admet-2387	144	38	of	of	ADP
admet-2387	144	39	o	o	NOUN
admet-2387	144	40	-	-	NOUN
admet-2387	144	41	dealkylation	dealkylation	NOUN
admet-2387	144	42	and	and	CCONJ
admet-2387	144	43	hydrogenation	hydrogenation	NOUN
admet-2387	144	44	,	,	PUNCT
admet-2387	144	45	this	this	DET
admet-2387	144	46	metabolite	metabolite	NOUN
admet-2387	144	47	was	be	AUX
admet-2387	144	48	also	also	ADV
admet-2387	144	49	determined	determine	VERB
admet-2387	144	50	in	in	ADP
admet-2387	144	51	rat	rat	NOUN
admet-2387	144	52	,	,	PUNCT
admet-2387	144	53	rabbit	rabbit	NOUN
admet-2387	144	54	and	and	CCONJ
admet-2387	144	55	human	human	ADJ
admet-2387	144	56	liver	liver	NOUN
admet-2387	144	57	s9	s9	NOUN
admet-2387	144	58	fractions	fraction	NOUN
admet-2387	144	59	by	by	ADP
admet-2387	144	60	cirello	cirello	PROPN
admet-2387	144	61	et	et	PROPN
admet-2387	144	62	al	al	PROPN
admet-2387	144	63	.	.	PUNCT
admet-2387	145	1	[	[	X
admet-2387	145	2	55	55	NUM
admet-2387	145	3	]	]	PUNCT
admet-2387	145	4	according	accord	VERB
admet-2387	145	5	to	to	ADP
admet-2387	145	6	the	the	DET
admet-2387	145	7	same	same	ADJ
admet-2387	145	8	fragment	fragment	NOUN
admet-2387	145	9	(	(	PUNCT
admet-2387	145	10	m	m	NOUN
admet-2387	145	11	/	/	SYM
admet-2387	145	12	z	z	NOUN
admet-2387	145	13	255.0086	255.0086	NUM
admet-2387	145	14	)	)	PUNCT
admet-2387	145	15	.	.	PUNCT
admet-2387	146	1	m3	m3	PROPN
admet-2387	146	2	showed	show	VERB
admet-2387	146	3	a	a	DET
admet-2387	146	4	protonated	protonate	VERB
admet-2387	146	5	molecular	molecular	ADJ
admet-2387	146	6	ion	ion	NOUN
admet-2387	146	7	at	at	ADP
admet-2387	146	8	m	m	PROPN
admet-2387	146	9	/	/	SYM
admet-2387	146	10	z	z	PROPN
admet-2387	146	11	343.0242	343.0242	NUM
admet-2387	146	12	,	,	PUNCT
admet-2387	146	13	its	its	PRON
admet-2387	146	14	cid	cid	NOUN
admet-2387	146	15	product	product	NOUN
admet-2387	146	16	ion	ion	NOUN
admet-2387	146	17	spectrum	spectrum	NOUN
admet-2387	146	18	showed	show	VERB
admet-2387	146	19	fragment	fragment	ADJ
admet-2387	146	20	ions	ion	NOUN
admet-2387	146	21	at	at	ADP
admet-2387	146	22	m	m	PROPN
admet-2387	146	23	/	/	SYM
admet-2387	146	24	z	z	PROPN
admet-2387	146	25	158.9763	158.9763	NUM
admet-2387	146	26	,	,	PUNCT
admet-2387	146	27	255.0086	255.0086	NUM
admet-2387	146	28	and	and	CCONJ
admet-2387	146	29	274.9870	274.9870	NUM
admet-2387	146	30	,	,	PUNCT
admet-2387	146	31	the	the	DET
admet-2387	146	32	loss	loss	NOUN
admet-2387	146	33	of	of	ADP
admet-2387	146	34	188	188	NUM
admet-2387	146	35	amu	amu	NOUN
admet-2387	146	36	to	to	ADP
admet-2387	146	37	the	the	DET
admet-2387	146	38	parent	parent	NOUN
admet-2387	146	39	ion	ion	NOUN
admet-2387	146	40	,	,	PUNCT
admet-2387	146	41	indicating	indicate	VERB
admet-2387	146	42	that	that	SCONJ
admet-2387	146	43	it	it	PRON
admet-2387	146	44	was	be	AUX
admet-2387	146	45	a	a	DET
admet-2387	146	46	metabolite	metabolite	NOUN
admet-2387	146	47	of	of	ADP
admet-2387	146	48	o	o	NOUN
admet-2387	146	49	-	-	NOUN
admet-2387	146	50	dealkylation	dealkylation	NOUN
admet-2387	146	51	and	and	CCONJ
admet-2387	146	52	monooxygenation	monooxygenation	NOUN
admet-2387	146	53	.	.	PUNCT
admet-2387	147	1	m6	m6	PROPN
admet-2387	147	2	showed	show	VERB
admet-2387	147	3	a	a	DET
admet-2387	147	4	protonated	protonate	VERB
admet-2387	147	5	molecular	molecular	ADJ
admet-2387	147	6	ion	ion	NOUN
admet-2387	147	7	at	at	ADP
admet-2387	147	8	m	m	PROPN
admet-2387	147	9	/	/	SYM
admet-2387	147	10	z	z	PROPN
admet-2387	147	11	480.1440	480.1440	NUM
admet-2387	147	12	,	,	PUNCT
admet-2387	147	13	its	its	PRON
admet-2387	147	14	cid	cid	NOUN
admet-2387	147	15	product	product	NOUN
admet-2387	147	16	ion	ion	NOUN
admet-2387	147	17	spectrum	spectrum	NOUN
admet-2387	147	18	displayed	display	VERB
admet-2387	147	19	fragment	fragment	ADJ
admet-2387	147	20	ions	ion	NOUN
admet-2387	147	21	at	at	ADP
admet-2387	147	22	m	m	PROPN
admet-2387	147	23	/	/	SYM
admet-2387	147	24	z	z	PROPN
admet-2387	147	25	112.0761	112.0761	NUM
admet-2387	147	26	,	,	PUNCT
admet-2387	147	27	219.1127	219.1127	NUM
admet-2387	147	28	,	,	PUNCT
admet-2387	147	29	421.1087	421.1087	NUM
admet-2387	147	30	and	and	CCONJ
admet-2387	147	31	463.1176	463.1176	NUM
admet-2387	147	32	,	,	PUNCT
admet-2387	147	33	the	the	DET
admet-2387	147	34	loss	loss	NOUN
admet-2387	147	35	of	of	ADP
admet-2387	147	36	51	51	NUM
admet-2387	147	37	amu	amu	NOUN
admet-2387	147	38	from	from	ADP
admet-2387	147	39	parent	parent	NOUN
admet-2387	147	40	ion	ion	NOUN
admet-2387	147	41	indicated	indicate	VERB
admet-2387	147	42	it	it	PRON
admet-2387	147	43	was	be	AUX
admet-2387	147	44	a	a	DET
admet-2387	147	45	metabolite	metabolite	NOUN
admet-2387	147	46	of	of	ADP
admet-2387	147	47	ring	ring	NOUN
admet-2387	147	48	-	-	PUNCT
admet-2387	147	49	opening	open	VERB
admet-2387	147	50	n	n	CCONJ
admet-2387	147	51	-	-	PUNCT
admet-2387	147	52	dealkylation	dealkylation	NOUN
admet-2387	147	53	.	.	PUNCT
admet-2387	148	1	as	as	SCONJ
admet-2387	148	2	indicated	indicate	VERB
admet-2387	148	3	in	in	ADP
admet-2387	148	4	figure	figure	NOUN
admet-2387	148	5	3	3	NUM
admet-2387	148	6	and	and	CCONJ
admet-2387	148	7	table	table	NOUN
admet-2387	148	8	1	1	NUM
admet-2387	148	9	,	,	PUNCT
admet-2387	148	10	ketoconazole	ketoconazole	PROPN
admet-2387	148	11	was	be	AUX
admet-2387	148	12	slowly	slowly	ADV
admet-2387	148	13	eliminated	eliminate	VERB
admet-2387	148	14	in	in	ADP
admet-2387	148	15	pooled	pool	VERB
admet-2387	148	16	plasma	plasma	NOUN
admet-2387	148	17	,	,	PUNCT
admet-2387	148	18	cornea	cornea	NOUN
admet-2387	148	19	,	,	PUNCT
admet-2387	148	20	retina	retina	NOUN
admet-2387	148	21	,	,	PUNCT
admet-2387	148	22	and	and	CCONJ
admet-2387	148	23	vitreous	vitreous	ADJ
admet-2387	148	24	humour	humour	NOUN
admet-2387	148	25	samples	sample	NOUN
admet-2387	148	26	within	within	ADP
admet-2387	148	27	120	120	NUM
admet-2387	148	28	min	min	NOUN
admet-2387	148	29	after	after	ADP
admet-2387	148	30	topical	topical	ADJ
admet-2387	148	31	ocular	ocular	ADJ
admet-2387	148	32	administration	administration	NOUN
admet-2387	148	33	,	,	PUNCT
admet-2387	148	34	and	and	CCONJ
admet-2387	148	35	it	it	PRON
admet-2387	148	36	was	be	AUX
admet-2387	148	37	still	still	ADV
admet-2387	148	38	a	a	DET
admet-2387	148	39	dominant	dominant	ADJ
admet-2387	148	40	component	component	NOUN
admet-2387	148	41	.	.	PUNCT
admet-2387	149	1	in	in	ADP
admet-2387	149	2	rat	rat	NOUN
admet-2387	149	3	plasma	plasma	NOUN
admet-2387	149	4	,	,	PUNCT
admet-2387	149	5	nine	nine	NUM
admet-2387	149	6	metabolites	metabolite	NOUN
admet-2387	149	7	of	of	ADP
admet-2387	149	8	ketoconazole	ketoconazole	NOUN
admet-2387	149	9	were	be	AUX
admet-2387	149	10	identified	identify	VERB
admet-2387	149	11	,	,	PUNCT
admet-2387	149	12	the	the	DET
admet-2387	149	13	top	top	ADJ
admet-2387	149	14	two	two	NUM
admet-2387	149	15	metabolites	metabolite	NOUN
admet-2387	149	16	were	be	AUX
admet-2387	149	17	m3	m3	PROPN
admet-2387	149	18	and	and	CCONJ
admet-2387	149	19	m11	m11	NOUN
admet-2387	149	20	,	,	PUNCT
admet-2387	149	21	accounting	account	VERB
admet-2387	149	22	for	for	ADP
admet-2387	149	23	5.0	5.0	NUM
admet-2387	149	24	and	and	CCONJ
admet-2387	149	25	5.8	5.8	NUM
admet-2387	149	26	%	%	NOUN
admet-2387	149	27	of	of	ADP
admet-2387	149	28	the	the	DET
admet-2387	149	29	total	total	ADJ
admet-2387	149	30	mass	mass	PROPN
admet-2387	149	31	abundance	abundance	NOUN
admet-2387	149	32	,	,	PUNCT
admet-2387	149	33	its	its	PRON
admet-2387	149	34	biotransformation	biotransformation	NOUN
admet-2387	149	35	involved	involve	VERB
admet-2387	149	36	odealkylation	odealkylation	NOUN
admet-2387	149	37	,	,	PUNCT
admet-2387	149	38	mono	mono	NOUN
admet-2387	149	39	-	-	PUNCT
admet-2387	149	40	oxygenation	oxygenation	NOUN
admet-2387	149	41	and	and	CCONJ
admet-2387	149	42	dehydrogenation	dehydrogenation	NOUN
admet-2387	149	43	.	.	PUNCT
admet-2387	150	1	in	in	ADP
admet-2387	150	2	the	the	DET
admet-2387	150	3	rat	rat	NOUN
admet-2387	150	4	cornea	cornea	NOUN
admet-2387	150	5	,	,	PUNCT
admet-2387	150	6	eleven	eleven	NUM
admet-2387	150	7	metabolites	metabolite	NOUN
admet-2387	150	8	were	be	AUX
admet-2387	150	9	identified	identify	VERB
admet-2387	150	10	.	.	PUNCT
admet-2387	151	1	the	the	DET
admet-2387	151	2	primary	primary	ADJ
admet-2387	151	3	metabolite	metabolite	NOUN
admet-2387	151	4	was	be	AUX
admet-2387	151	5	m2	m2	PROPN
admet-2387	151	6	,	,	PUNCT
admet-2387	151	7	which	which	PRON
admet-2387	151	8	underwent	undergo	VERB
admet-2387	151	9	biotransformation	biotransformation	NOUN
admet-2387	151	10	through	through	ADP
admet-2387	151	11	o	o	NOUN
admet-2387	151	12	-	-	NOUN
admet-2387	151	13	dealkylation	dealkylation	NOUN
admet-2387	151	14	and	and	CCONJ
admet-2387	151	15	hydrogenation	hydrogenation	NOUN
admet-2387	151	16	.	.	PUNCT
admet-2387	152	1	in	in	ADP
admet-2387	152	2	the	the	DET
admet-2387	152	3	rat	rat	NOUN
admet-2387	152	4	retina	retina	NOUN
admet-2387	152	5	,	,	PUNCT
admet-2387	152	6	two	two	NUM
admet-2387	152	7	metabolites	metabolite	NOUN
admet-2387	152	8	were	be	AUX
admet-2387	152	9	identified	identify	VERB
admet-2387	152	10	,	,	PUNCT
admet-2387	152	11	with	with	ADP
admet-2387	152	12	m2	m2	PROPN
admet-2387	152	13	being	be	AUX
admet-2387	152	14	the	the	DET
admet-2387	152	15	top	top	ADJ
admet-2387	152	16	one	one	NUM
admet-2387	152	17	.	.	PUNCT
admet-2387	153	1	in	in	ADP
admet-2387	153	2	the	the	DET
admet-2387	153	3	vitreous	vitreous	ADJ
admet-2387	153	4	humour	humour	NOUN
admet-2387	153	5	,	,	PUNCT
admet-2387	153	6	two	two	NUM
admet-2387	153	7	metabolites	metabolite	NOUN
admet-2387	153	8	were	be	AUX
admet-2387	153	9	identified	identify	VERB
admet-2387	153	10	,	,	PUNCT
admet-2387	153	11	with	with	ADP
admet-2387	153	12	m2	m2	PROPN
admet-2387	153	13	remaining	remain	VERB
admet-2387	153	14	the	the	DET
admet-2387	153	15	primary	primary	ADJ
admet-2387	153	16	one	one	NOUN
admet-2387	153	17	.	.	PUNCT
admet-2387	154	1	figure	figure	NOUN
admet-2387	154	2	5	5	NUM
admet-2387	154	3	.	.	PUNCT
admet-2387	154	4	proposed	propose	VERB
admet-2387	154	5	metabolic	metabolic	NOUN
admet-2387	154	6	pathways	pathway	NOUN
admet-2387	154	7	of	of	ADP
admet-2387	154	8	ketoconazole	ketoconazole	NOUN
admet-2387	154	9	in	in	ADP
admet-2387	154	10	rat	rat	NOUN
admet-2387	154	11	plasma	plasma	NOUN
admet-2387	154	12	and	and	CCONJ
admet-2387	154	13	ocular	ocular	ADJ
admet-2387	154	14	tissues	tissue	NOUN
admet-2387	154	15	as	as	SCONJ
admet-2387	154	16	summarized	summarize	VERB
admet-2387	154	17	in	in	ADP
admet-2387	154	18	figure	figure	NOUN
admet-2387	154	19	5	5	NUM
admet-2387	154	20	and	and	CCONJ
admet-2387	154	21	table	table	NOUN
admet-2387	154	22	1	1	NUM
admet-2387	154	23	,	,	PUNCT
admet-2387	154	24	observed	observe	VERB
admet-2387	154	25	metabolic	metabolic	NOUN
admet-2387	154	26	pathways	pathway	NOUN
admet-2387	154	27	included	include	VERB
admet-2387	154	28	o	o	NOUN
admet-2387	154	29	-	-	NOUN
admet-2387	154	30	dealkylation	dealkylation	NOUN
admet-2387	154	31	,	,	PUNCT
admet-2387	154	32	hydrogenation	hydrogenation	NOUN
admet-2387	154	33	,	,	PUNCT
admet-2387	154	34	mono	mono	NOUN
admet-2387	154	35	-	-	PUNCT
admet-2387	154	36	oxygenation	oxygenation	NOUN
admet-2387	154	37	,	,	PUNCT
admet-2387	154	38	hydrolysis	hydrolysis	NOUN
admet-2387	154	39	,	,	PUNCT
admet-2387	154	40	and	and	CCONJ
admet-2387	154	41	dehydrogenation	dehydrogenation	NOUN
admet-2387	154	42	,	,	PUNCT
admet-2387	154	43	consistent	consistent	ADJ
admet-2387	154	44	with	with	ADP
admet-2387	154	45	previous	previous	ADJ
admet-2387	154	46	studies	study	NOUN
admet-2387	154	47	[	[	X
admet-2387	154	48	13,55	13,55	NUM
admet-2387	154	49	]	]	PUNCT
admet-2387	154	50	.	.	PUNCT
admet-2387	155	1	interestingly	interestingly	ADV
admet-2387	155	2	,	,	PUNCT
admet-2387	155	3	an	an	DET
admet-2387	155	4	aldehyde	aldehyde	NOUN
admet-2387	155	5	metabolite	metabolite	NOUN
admet-2387	155	6	labelled	label	VERB
admet-2387	155	7	as	as	ADP
admet-2387	155	8	an	an	DET
admet-2387	155	9	intermediate	intermediate	ADJ
admet-2387	155	10	via	via	ADP
admet-2387	155	11	o	o	NOUN
admet-2387	155	12	-	-	NOUN
admet-2387	155	13	dealkylation	dealkylation	NOUN
admet-2387	155	14	,	,	PUNCT
admet-2387	155	15	which	which	PRON
admet-2387	155	16	is	be	AUX
admet-2387	155	17	responsible	responsible	ADJ
admet-2387	155	18	for	for	ADP
admet-2387	155	19	the	the	DET
admet-2387	155	20	subsequent	subsequent	ADJ
admet-2387	155	21	hydrogenation	hydrogenation	NOUN
admet-2387	155	22	to	to	ADP
admet-2387	155	23	m2	m2	PROPN
admet-2387	155	24	and	and	CCONJ
admet-2387	155	25	mono	mono	NOUN
admet-2387	155	26	-	-	PUNCT
admet-2387	155	27	oxygenation	oxygenation	NOUN
admet-2387	155	28	to	to	ADP
admet-2387	155	29	m3	m3	PROPN
admet-2387	155	30	,	,	PUNCT
admet-2387	155	31	was	be	AUX
admet-2387	155	32	not	not	PART
admet-2387	155	33	detected	detect	VERB
admet-2387	155	34	in	in	ADP
admet-2387	155	35	this	this	DET
admet-2387	155	36	study	study	NOUN
admet-2387	155	37	.	.	PUNCT
admet-2387	156	1	in	in	ADP
admet-2387	156	2	cirello	cirello	PROPN
admet-2387	156	3	’s	’s	PART
admet-2387	156	4	study	study	NOUN
admet-2387	156	5	[	[	X
admet-2387	156	6	55	55	NUM
admet-2387	156	7	]	]	PUNCT
admet-2387	156	8	,	,	PUNCT
admet-2387	156	9	“	"	PUNCT
admet-2387	156	10	m10	m10	PROPN
admet-2387	156	11	”	"	PUNCT
admet-2387	156	12	(	(	PUNCT
admet-2387	156	13	m	m	NOUN
admet-2387	156	14	/	/	SYM
admet-2387	156	15	z	z	PROPN
admet-2387	156	16	329.0456	329.0456	NUM
admet-2387	156	17	)	)	PUNCT
admet-2387	156	18	has	have	VERB
admet-2387	156	19	a	a	DET
admet-2387	156	20	fragment	fragment	NOUN
admet-2387	156	21	(	(	PUNCT
admet-2387	156	22	m	m	NOUN
admet-2387	156	23	/	/	SYM
admet-2387	156	24	z	z	NOUN
admet-2387	156	25	255.0081	255.0081	NUM
admet-2387	156	26	)	)	PUNCT
admet-2387	156	27	and	and	CCONJ
admet-2387	156	28	the	the	DET
admet-2387	156	29	comparison	comparison	NOUN
admet-2387	156	30	suggests	suggest	VERB
admet-2387	156	31	that	that	SCONJ
admet-2387	156	32	“	"	PUNCT
admet-2387	156	33	m10	m10	PROPN
admet-2387	156	34	”	"	PUNCT
admet-2387	156	35	is	be	AUX
admet-2387	156	36	equivalent	equivalent	ADJ
admet-2387	156	37	to	to	ADP
admet-2387	156	38	m2	m2	PROPN
admet-2387	156	39	(	(	PUNCT
admet-2387	156	40	m	m	PROPN
admet-2387	156	41	/	/	SYM
admet-2387	156	42	z	z	PROPN
admet-2387	156	43	329.0454	329.0454	NUM
admet-2387	156	44	)	)	PUNCT
admet-2387	156	45	with	with	ADP
admet-2387	156	46	its	its	PRON
admet-2387	156	47	fragment	fragment	ADJ
admet-2387	156	48	ions	ion	NOUN
admet-2387	156	49	(	(	PUNCT
admet-2387	156	50	m	m	NOUN
admet-2387	156	51	/	/	SYM
admet-2387	156	52	z	z	NOUN
admet-2387	156	53	158.9761	158.9761	NUM
admet-2387	156	54	,	,	PUNCT
admet-2387	156	55	255.0080	255.0080	NUM
admet-2387	156	56	)	)	PUNCT
admet-2387	156	57	of	of	ADP
admet-2387	156	58	this	this	DET
admet-2387	156	59	study	study	NOUN
admet-2387	156	60	.	.	PUNCT
admet-2387	157	1	in	in	ADP
admet-2387	157	2	addition	addition	NOUN
admet-2387	157	3	,	,	PUNCT
admet-2387	157	4	in	in	ADP
admet-2387	157	5	fitch	fitch	PROPN
admet-2387	157	6	’s	’s	PART
admet-2387	157	7	study	study	NOUN
admet-2387	158	1	[	[	X
admet-2387	158	2	56	56	NUM
admet-2387	158	3	]	]	PUNCT
admet-2387	158	4	,	,	PUNCT
admet-2387	158	5	“	"	PUNCT
admet-2387	158	6	m16	m16	NOUN
admet-2387	158	7	”	"	PUNCT
admet-2387	158	8	(	(	PUNCT
admet-2387	158	9	m	m	NOUN
admet-2387	158	10	/	/	SYM
admet-2387	158	11	z	z	PROPN
admet-2387	158	12	343.0256	343.0256	NUM
admet-2387	158	13	)	)	PUNCT
admet-2387	158	14	has	have	VERB
admet-2387	158	15	three	three	NUM
admet-2387	158	16	fragment	fragment	ADJ
admet-2387	158	17	ions	ion	NOUN
admet-2387	158	18	(	(	PUNCT
admet-2387	158	19	m	m	NOUN
admet-2387	158	20	/	/	SYM
admet-2387	158	21	z	z	PROPN
admet-2387	158	22	159	159	NUM
admet-2387	158	23	.	.	PUNCT
admet-2387	159	1	275	275	NUM
admet-2387	159	2	,	,	PUNCT
admet-2387	159	3	255	255	NUM
admet-2387	159	4	)	)	PUNCT
admet-2387	160	1	and	and	CCONJ
admet-2387	160	2	the	the	DET
admet-2387	160	3	comparison	comparison	NOUN
admet-2387	160	4	suggests	suggest	VERB
admet-2387	160	5	that	that	SCONJ
admet-2387	160	6	“	"	PUNCT
admet-2387	160	7	m16	m16	NOUN
admet-2387	160	8	”	"	PUNCT
admet-2387	160	9	is	be	AUX
admet-2387	160	10	equivalent	equivalent	ADJ
admet-2387	160	11	to	to	ADP
admet-2387	160	12	m3	m3	PROPN
admet-2387	160	13	(	(	PUNCT
admet-2387	160	14	m	m	PROPN
admet-2387	160	15	/	/	SYM
admet-2387	160	16	z	z	PROPN
admet-2387	160	17	343.0247	343.0247	NUM
admet-2387	160	18	)	)	PUNCT
admet-2387	160	19	with	with	ADP
admet-2387	160	20	its	its	PRON
admet-2387	160	21	fragment	fragment	ADJ
admet-2387	160	22	ions	ion	NOUN
admet-2387	160	23	(	(	PUNCT
admet-2387	160	24	m	m	NOUN
admet-2387	160	25	/	/	SYM
admet-2387	160	26	z	z	PROPN
admet-2387	160	27	admet	admet	PROPN
admet-2387	160	28	&	&	CCONJ
admet-2387	160	29	dmpk	dmpk	PROPN
admet-2387	160	30	12(6	12(6	NUM
admet-2387	160	31	)	)	PUNCT
admet-2387	160	32	(	(	PUNCT
admet-2387	160	33	2024	2024	NUM
admet-2387	160	34	)	)	PUNCT
admet-2387	160	35	943	943	NUM
admet-2387	160	36	-	-	SYM
admet-2387	160	37	955	955	NUM
admet-2387	160	38	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	160	39	and	and	CCONJ
admet-2387	160	40	metabolism	metabolism	NOUN
admet-2387	160	41	of	of	ADP
admet-2387	160	42	ketoconazole	ketoconazole	PROPN
admet-2387	160	43	doi	doi	PROPN
admet-2387	160	44	:	:	PUNCT
admet-2387	160	45	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	160	46	951	951	NUM
admet-2387	160	47	158.9761	158.9761	NUM
admet-2387	160	48	,	,	PUNCT
admet-2387	160	49	274.9870	274.9870	NUM
admet-2387	160	50	,	,	PUNCT
admet-2387	160	51	255.0087	255.0087	NUM
admet-2387	160	52	)	)	PUNCT
admet-2387	160	53	of	of	ADP
admet-2387	160	54	this	this	DET
admet-2387	160	55	study	study	NOUN
admet-2387	160	56	.	.	PUNCT
admet-2387	161	1	m3	m3	PROPN
admet-2387	161	2	in	in	ADP
admet-2387	161	3	this	this	DET
admet-2387	161	4	study	study	NOUN
admet-2387	161	5	was	be	AUX
admet-2387	161	6	also	also	ADV
admet-2387	161	7	identified	identify	VERB
admet-2387	161	8	in	in	ADP
admet-2387	161	9	kim	kim	PROPN
admet-2387	161	10	’s	’s	PART
admet-2387	161	11	work	work	NOUN
admet-2387	161	12	[	[	X
admet-2387	161	13	58	58	NUM
admet-2387	161	14	]	]	PUNCT
admet-2387	161	15	as	as	ADP
admet-2387	161	16	“	"	PUNCT
admet-2387	161	17	m14	m14	NOUN
admet-2387	161	18	”	"	PUNCT
admet-2387	161	19	(	(	PUNCT
admet-2387	161	20	m	m	NOUN
admet-2387	161	21	/	/	SYM
admet-2387	161	22	z	z	PROPN
admet-2387	161	23	343.0247	343.0247	NUM
admet-2387	161	24	)	)	PUNCT
admet-2387	161	25	.	.	PUNCT
admet-2387	162	1	in	in	ADP
admet-2387	162	2	early	early	ADJ
admet-2387	162	3	reports	report	NOUN
admet-2387	162	4	[	[	X
admet-2387	162	5	11	11	NUM
admet-2387	162	6	-	-	SYM
admet-2387	162	7	14	14	NUM
admet-2387	162	8	]	]	PUNCT
admet-2387	162	9	,	,	PUNCT
admet-2387	162	10	n	n	CCONJ
admet-2387	162	11	-	-	PUNCT
admet-2387	162	12	deacetyl	deacetyl	NOUN
admet-2387	162	13	ketoconazole	ketoconazole	NOUN
admet-2387	162	14	was	be	AUX
admet-2387	162	15	also	also	ADV
admet-2387	162	16	identified	identify	VERB
admet-2387	162	17	as	as	ADP
admet-2387	162	18	m4	m4	PROPN
admet-2387	162	19	,	,	PUNCT
admet-2387	162	20	and	and	CCONJ
admet-2387	162	21	it	it	PRON
admet-2387	162	22	possessed	possess	VERB
admet-2387	162	23	a	a	DET
admet-2387	162	24	bioactivation	bioactivation	NOUN
admet-2387	162	25	function	function	NOUN
admet-2387	162	26	that	that	PRON
admet-2387	162	27	could	could	AUX
admet-2387	162	28	potentially	potentially	ADV
admet-2387	162	29	be	be	AUX
admet-2387	162	30	transformed	transform	VERB
admet-2387	162	31	into	into	ADP
admet-2387	162	32	a	a	DET
admet-2387	162	33	cytotoxic	cytotoxic	ADJ
admet-2387	162	34	agent	agent	NOUN
admet-2387	162	35	.	.	PUNCT
admet-2387	163	1	however	however	ADV
admet-2387	163	2	,	,	PUNCT
admet-2387	163	3	it	it	PRON
admet-2387	163	4	was	be	AUX
admet-2387	163	5	not	not	PART
admet-2387	163	6	detected	detect	VERB
admet-2387	163	7	in	in	ADP
admet-2387	163	8	rat	rat	NOUN
admet-2387	163	9	plasma	plasma	NOUN
admet-2387	163	10	,	,	PUNCT
admet-2387	163	11	suggesting	suggest	VERB
admet-2387	163	12	that	that	SCONJ
admet-2387	163	13	the	the	DET
admet-2387	163	14	hepatic	hepatic	ADJ
admet-2387	163	15	toxicity	toxicity	NOUN
admet-2387	163	16	potential	potential	NOUN
admet-2387	163	17	is	be	AUX
admet-2387	163	18	unlikely	unlikely	ADJ
admet-2387	163	19	to	to	PART
admet-2387	163	20	occur	occur	VERB
admet-2387	163	21	in	in	ADP
admet-2387	163	22	rats	rat	NOUN
admet-2387	163	23	due	due	ADP
admet-2387	163	24	to	to	ADP
admet-2387	163	25	the	the	DET
admet-2387	163	26	low	low	ADJ
admet-2387	163	27	systemic	systemic	ADJ
admet-2387	163	28	concentration	concentration	NOUN
admet-2387	163	29	after	after	ADP
admet-2387	163	30	ocular	ocular	ADJ
admet-2387	163	31	administration	administration	NOUN
admet-2387	163	32	.	.	PUNCT
admet-2387	164	1	ketoconazole	ketoconazole	PROPN
admet-2387	164	2	was	be	AUX
admet-2387	164	3	a	a	DET
admet-2387	164	4	dominant	dominant	ADJ
admet-2387	164	5	component	component	NOUN
admet-2387	164	6	in	in	ADP
admet-2387	164	7	the	the	DET
admet-2387	164	8	cornea	cornea	NOUN
admet-2387	164	9	,	,	PUNCT
admet-2387	164	10	retina	retina	NOUN
admet-2387	164	11	,	,	PUNCT
admet-2387	164	12	and	and	CCONJ
admet-2387	164	13	vitreous	vitreous	ADJ
admet-2387	164	14	humour	humour	NOUN
admet-2387	164	15	.	.	PUNCT
admet-2387	165	1	this	this	PRON
admet-2387	165	2	may	may	AUX
admet-2387	165	3	suggest	suggest	VERB
admet-2387	165	4	a	a	DET
admet-2387	165	5	better	well	ADJ
admet-2387	165	6	fit	fit	NOUN
admet-2387	165	7	for	for	ADP
admet-2387	165	8	topical	topical	ADJ
admet-2387	165	9	usage	usage	NOUN
admet-2387	165	10	in	in	ADP
admet-2387	165	11	rats	rat	NOUN
admet-2387	165	12	and	and	CCONJ
admet-2387	165	13	,	,	PUNCT
admet-2387	165	14	eventually	eventually	ADV
admet-2387	165	15	,	,	PUNCT
admet-2387	165	16	in	in	ADP
admet-2387	165	17	human	human	ADJ
admet-2387	165	18	topical	topical	ADJ
admet-2387	165	19	ocular	ocular	ADJ
admet-2387	165	20	use	use	NOUN
admet-2387	165	21	.	.	PUNCT
admet-2387	166	1	table	table	NOUN
admet-2387	166	2	1	1	NUM
admet-2387	166	3	.	.	PUNCT
admet-2387	166	4	observed	observe	VERB
admet-2387	166	5	metabolites	metabolite	NOUN
admet-2387	166	6	of	of	ADP
admet-2387	166	7	ketoconazole	ketoconazole	NOUN
admet-2387	166	8	in	in	ADP
admet-2387	166	9	rat	rat	NOUN
admet-2387	166	10	plasma	plasma	NOUN
admet-2387	166	11	and	and	CCONJ
admet-2387	166	12	ocular	ocular	ADJ
admet-2387	166	13	tissues	tissue	NOUN
admet-2387	166	14	after	after	SCONJ
admet-2387	166	15	eye	eye	NOUN
admet-2387	166	16	drop	drop	NOUN
admet-2387	166	17	administration	administration	NOUN
admet-2387	166	18	met	meet	VERB
admet-2387	166	19	#	#	PROPN
admet-2387	166	20	rt	rt	PROPN
admet-2387	166	21	,	,	PUNCT
admet-2387	166	22	min	min	PROPN
admet-2387	166	23	m	m	PROPN
admet-2387	166	24	/	/	SYM
admet-2387	166	25	z	z	PROPN
admet-2387	166	26	(	(	PUNCT
admet-2387	166	27	+	+	ADJ
admet-2387	166	28	)	)	PUNCT
admet-2387	166	29	mass	mass	ADJ
admet-2387	166	30	error	error	NOUN
admet-2387	166	31	,	,	PUNCT
admet-2387	166	32	ppm	ppm	ADJ
admet-2387	166	33	metabolite	metabolite	NOUN
admet-2387	166	34	pathway	pathway	NOUN
admet-2387	166	35	relative	relative	PROPN
admet-2387	166	36	peak	peak	PROPN
admet-2387	166	37	area	area	NOUN
admet-2387	166	38	abundance	abundance	NOUN
admet-2387	166	39	,	,	PUNCT
admet-2387	166	40	%	%	INTJ
admet-2387	166	41	ref	ref	NOUN
admet-2387	166	42	.	.	PUNCT
admet-2387	167	1	theoretica	theoretica	PROPN
admet-2387	167	2	detected	detect	VERB
admet-2387	167	3	cor	cor	PROPN
admet-2387	167	4	ret	ret	PROPN
admet-2387	167	5	vh	vh	PROPN
admet-2387	167	6	pla	pla	PROPN
admet-2387	167	7	m1	m1	PROPN
admet-2387	167	8	8.91	8.91	NUM
admet-2387	167	9	547.1510	547.1510	NUM
admet-2387	167	10	547.1500	547.1500	NUM
admet-2387	167	11	-1.8	-1.8	NUM
admet-2387	167	12	mono	mono	NOUN
admet-2387	167	13	-	-	PUNCT
admet-2387	167	14	oxygenation	oxygenation	NOUN
admet-2387	168	1	d	d	NOUN
admet-2387	168	2	nd	nd	NOUN
admet-2387	168	3	d	d	NOUN
admet-2387	168	4	nd	nd	NOUN
admet-2387	168	5	[	[	X
admet-2387	168	6	55,56,58	55,56,58	NOUN
admet-2387	168	7	]	]	X
admet-2387	168	8	m2	m2	PROPN
admet-2387	168	9	9.16	9.16	NUM
admet-2387	169	1	329.0454	329.0454	NUM
admet-2387	169	2	329.0446	329.0446	NUM
admet-2387	169	3	-2.4	-2.4	NOUN
admet-2387	169	4	o	o	NOUN
admet-2387	169	5	-	-	NOUN
admet-2387	169	6	dealkylation	dealkylation	NOUN
admet-2387	169	7	and	and	CCONJ
admet-2387	169	8	hydrogenation	hydrogenation	NOUN
admet-2387	169	9	1.1	1.1	NUM
admet-2387	169	10	1.2	1.2	NUM
admet-2387	169	11	0.6	0.6	NUM
admet-2387	169	12	0.1	0.1	NUM
admet-2387	170	1	[	[	X
admet-2387	170	2	55,56	55,56	NOUN
admet-2387	170	3	]	]	X
admet-2387	170	4	m3	m3	PROPN
admet-2387	170	5	9.44	9.44	NUM
admet-2387	170	6	343.0247	343.0247	NUM
admet-2387	170	7	343.0242	343.0242	NUM
admet-2387	170	8	-1.5	-1.5	SYM
admet-2387	170	9	o	o	NOUN
admet-2387	170	10	-	-	NOUN
admet-2387	170	11	dealkylation	dealkylation	NOUN
admet-2387	170	12	and	and	CCONJ
admet-2387	170	13	mono	mono	NOUN
admet-2387	170	14	-	-	PUNCT
admet-2387	170	15	oxygenation	oxygenation	NOUN
admet-2387	170	16	d	d	NOUN
admet-2387	170	17	nd	nd	INTJ
admet-2387	170	18	nd	nd	ADV
admet-2387	170	19	5.0	5.0	NUM
admet-2387	170	20	[	[	X
admet-2387	170	21	56,58	56,58	NUM
admet-2387	170	22	]	]	X
admet-2387	170	23	m4	m4	PROPN
admet-2387	170	24	(	(	PUNCT
admet-2387	170	25	dak	dak	PROPN
admet-2387	170	26	)	)	PUNCT
admet-2387	170	27	9.56	9.56	NUM
admet-2387	170	28	489.1455	489.1455	NUM
admet-2387	170	29	489.1449	489.1449	NUM
admet-2387	170	30	-1.2	-1.2	NOUN
admet-2387	170	31	hydrolysis	hydrolysis	NOUN
admet-2387	170	32	0.2	0.2	NUM
admet-2387	170	33	nd	nd	PRON
admet-2387	170	34	nd	nd	NOUN
admet-2387	170	35	nd	nd	NOUN
admet-2387	171	1	[	[	X
admet-2387	171	2	11,13,30	11,13,30	NUM
admet-2387	171	3	,	,	PUNCT
admet-2387	171	4	55,56,58	55,56,58	NUM
admet-2387	171	5	]	]	X
admet-2387	171	6	m5	m5	NOUN
admet-2387	171	7	9.73	9.73	NUM
admet-2387	171	8	505.1404	505.1404	NUM
admet-2387	171	9	505.1399	505.1399	NUM
admet-2387	171	10	-1.0	-1.0	NOUN
admet-2387	171	11	hydrolysis	hydrolysis	NOUN
admet-2387	171	12	and	and	CCONJ
admet-2387	171	13	monooxygenation	monooxygenation	NOUN
admet-2387	172	1	d	d	INTJ
admet-2387	172	2	nd	nd	INTJ
admet-2387	172	3	nd	nd	ADV
admet-2387	172	4	nd	nd	NOUN
admet-2387	172	5	[	[	X
admet-2387	172	6	55,56,58	55,56,58	NUM
admet-2387	172	7	]	]	X
admet-2387	172	8	m6	m6	VERB
admet-2387	172	9	11.41	11.41	NUM
admet-2387	172	10	480.1451	480.1451	NUM
admet-2387	172	11	480.1440	480.1440	NUM
admet-2387	172	12	-2.3	-2.3	NOUN
admet-2387	172	13	ring	ring	NOUN
admet-2387	172	14	-	-	PUNCT
admet-2387	172	15	opening	open	VERB
admet-2387	172	16	n	n	CCONJ
admet-2387	172	17	-	-	PUNCT
admet-2387	172	18	dealkylation	dealkylation	NOUN
admet-2387	172	19	0.1	0.1	NUM
admet-2387	172	20	nd	nd	PRON
admet-2387	172	21	nd	nd	NOUN
admet-2387	172	22	0.6	0.6	NUM
admet-2387	173	1	[	[	X
admet-2387	173	2	56	56	NUM
admet-2387	173	3	]	]	X
admet-2387	173	4	m7	m7	PROPN
admet-2387	173	5	11.92	11.92	NUM
admet-2387	173	6	545.1353	545.1353	NUM
admet-2387	173	7	545.1343	545.1343	NUM
admet-2387	173	8	-1.8	-1.8	NUM
admet-2387	173	9	mono	mono	NOUN
admet-2387	173	10	-	-	PUNCT
admet-2387	173	11	oxygenation	oxygenation	NOUN
admet-2387	173	12	and	and	CCONJ
admet-2387	173	13	dehydrogenation	dehydrogenation	NOUN
admet-2387	173	14	d	d	PROPN
admet-2387	173	15	nd	nd	INTJ
admet-2387	173	16	nd	nd	NOUN
admet-2387	173	17	0.6	0.6	NUM
admet-2387	173	18	[	[	X
admet-2387	173	19	55,56,58	55,56,58	NUM
admet-2387	173	20	]	]	X
admet-2387	173	21	m8	m8	PROPN
admet-2387	173	22	11.98	11.98	NUM
admet-2387	173	23	547.1510	547.1510	NUM
admet-2387	173	24	547.1531	547.1531	NUM
admet-2387	173	25	3.8	3.8	NUM
admet-2387	173	26	mono	mono	NOUN
admet-2387	173	27	-	-	PUNCT
admet-2387	173	28	oxygenation	oxygenation	NOUN
admet-2387	173	29	0.2	0.2	NUM
admet-2387	173	30	nd	nd	PRON
admet-2387	173	31	nd	nd	PRON
admet-2387	173	32	nd	nd	NOUN
admet-2387	173	33	[	[	X
admet-2387	173	34	55,56,58	55,56,58	NUM
admet-2387	173	35	]	]	X
admet-2387	173	36	m9	m9	NOUN
admet-2387	173	37	12.56	12.56	NUM
admet-2387	173	38	545.1353	545.1353	NUM
admet-2387	173	39	545.1337	545.1337	NUM
admet-2387	173	40	-2.9	-2.9	NOUN
admet-2387	173	41	mono	mono	NOUN
admet-2387	173	42	-	-	PUNCT
admet-2387	173	43	oxygenation	oxygenation	NOUN
admet-2387	173	44	and	and	CCONJ
admet-2387	173	45	dehydrogenation	dehydrogenation	NOUN
admet-2387	173	46	d	d	PROPN
admet-2387	173	47	d	d	PROPN
admet-2387	173	48	nd	nd	SYM
admet-2387	173	49	0.1	0.1	NUM
admet-2387	173	50	[	[	X
admet-2387	173	51	55,56,58	55,56,58	NUM
admet-2387	173	52	]	]	X
admet-2387	173	53	m10	m10	NOUN
admet-2387	173	54	13.05	13.05	NUM
admet-2387	173	55	547.1510	547.1510	NUM
admet-2387	173	56	547.1496	547.1496	NUM
admet-2387	173	57	-2.6	-2.6	PROPN
admet-2387	173	58	mono	mono	NOUN
admet-2387	173	59	-	-	PUNCT
admet-2387	173	60	oxygenation	oxygenation	NOUN
admet-2387	174	1	d	d	NOUN
admet-2387	174	2	nd	nd	INTJ
admet-2387	174	3	nd	nd	NOUN
admet-2387	174	4	0.6	0.6	NUM
admet-2387	175	1	[	[	X
admet-2387	175	2	55,56,58	55,56,58	NUM
admet-2387	175	3	]	]	X
admet-2387	175	4	kcz	kcz	NOUN
admet-2387	175	5	13.06	13.06	NUM
admet-2387	175	6	531.1560	531.1560	NUM
admet-2387	175	7	531.1550	531.1550	NUM
admet-2387	175	8	-1.9	-1.9	NUM
admet-2387	175	9	-98.3	-98.3	NUM
admet-2387	175	10	98.8	98.8	NUM
admet-2387	175	11	99.4	99.4	NUM
admet-2387	175	12	85.4	85.4	NUM
admet-2387	175	13	-	-	PUNCT
admet-2387	175	14	m11	m11	NOUN
admet-2387	175	15	15.83	15.83	NUM
admet-2387	175	16	529.1404	529.1404	NUM
admet-2387	175	17	529.1390	529.1390	NUM
admet-2387	175	18	-2.6	-2.6	NOUN
admet-2387	175	19	dehydrogenation	dehydrogenation	NOUN
admet-2387	175	20	nd	nd	INTJ
admet-2387	175	21	nd	nd	INTJ
admet-2387	175	22	nd	nd	ADV
admet-2387	175	23	5.8	5.8	NUM
admet-2387	175	24	[	[	X
admet-2387	175	25	55,58	55,58	NUM
admet-2387	175	26	]	]	X
admet-2387	175	27	m12	m12	NOUN
admet-2387	175	28	15.88	15.88	NUM
admet-2387	175	29	545.1353	545.1353	NUM
admet-2387	175	30	545.1343	545.1343	NUM
admet-2387	175	31	-1.8	-1.8	NUM
admet-2387	175	32	mono	mono	NOUN
admet-2387	175	33	-	-	PUNCT
admet-2387	175	34	oxygenation	oxygenation	NOUN
admet-2387	175	35	and	and	CCONJ
admet-2387	175	36	dehydrogenation	dehydrogenation	NOUN
admet-2387	175	37	nd	nd	INTJ
admet-2387	175	38	nd	nd	INTJ
admet-2387	175	39	nd	nd	ADV
admet-2387	175	40	1.6	1.6	NUM
admet-2387	175	41	[	[	SYM
admet-2387	175	42	55,56,58	55,56,58	NUM
admet-2387	175	43	]	]	X
admet-2387	175	44	m13	m13	VERB
admet-2387	175	45	16.34	16.34	NUM
admet-2387	175	46	545.1353	545.1353	NUM
admet-2387	175	47	545.1345	545.1345	NUM
admet-2387	175	48	-1.5	-1.5	NOUN
admet-2387	175	49	mono	mono	NOUN
admet-2387	175	50	-	-	PUNCT
admet-2387	175	51	oxygenation	oxygenation	NOUN
admet-2387	175	52	and	and	CCONJ
admet-2387	175	53	dehydrogenation	dehydrogenation	NOUN
admet-2387	175	54	0.1	0.1	NUM
admet-2387	175	55	nd	nd	PRON
admet-2387	175	56	nd	nd	NOUN
admet-2387	175	57	0.2	0.2	NUM
admet-2387	175	58	[	[	NOUN
admet-2387	175	59	55,56,58	55,56,58	NUM
admet-2387	175	60	]	]	X
admet-2387	175	61	note	note	NOUN
admet-2387	175	62	:	:	PUNCT
admet-2387	175	63	kcz	kcz	ADJ
admet-2387	175	64	ketoconazole	ketoconazole	NOUN
admet-2387	175	65	;	;	PUNCT
admet-2387	175	66	met	meet	VERB
admet-2387	175	67	#	#	NOUN
admet-2387	175	68	metabolite	metabolite	NOUN
admet-2387	175	69	identity	identity	NOUN
admet-2387	175	70	number	number	NOUN
admet-2387	175	71	;	;	PUNCT
admet-2387	175	72	cor	cor	PROPN
admet-2387	175	73	cornea	cornea	PROPN
admet-2387	175	74	;	;	PUNCT
admet-2387	175	75	ret	ret	NOUN
admet-2387	175	76	retina	retina	NOUN
admet-2387	175	77	;	;	PUNCT
admet-2387	175	78	vh	vh	NUM
admet-2387	175	79	vitreous	vitreous	ADJ
admet-2387	175	80	humour	humour	NOUN
admet-2387	175	81	;	;	PUNCT
admet-2387	175	82	pla	pla	NOUN
admet-2387	175	83	plasma	plasma	NOUN
admet-2387	175	84	;	;	PUNCT
admet-2387	175	85	rt	rt	NOUN
admet-2387	175	86	retention	retention	NOUN
admet-2387	175	87	time	time	NOUN
admet-2387	175	88	;	;	PUNCT
admet-2387	175	89	d	d	ADP
admet-2387	175	90	detected	detect	VERB
admet-2387	175	91	in	in	ADP
admet-2387	175	92	trace	trace	NOUN
admet-2387	175	93	amount	amount	NOUN
admet-2387	175	94	(	(	PUNCT
admet-2387	175	95	the	the	DET
admet-2387	175	96	relative	relative	ADJ
admet-2387	175	97	abundance	abundance	NOUN
admet-2387	175	98	was	be	AUX
admet-2387	175	99	less	less	ADJ
admet-2387	175	100	than	than	ADP
admet-2387	175	101	0.1	0.1	NUM
admet-2387	175	102	%	%	NOUN
admet-2387	175	103	)	)	PUNCT
admet-2387	175	104	;	;	PUNCT
admet-2387	175	105	nd	nd	ADV
admet-2387	175	106	not	not	PART
admet-2387	175	107	detected	detect	VERB
admet-2387	175	108	;	;	PUNCT
admet-2387	175	109	rt	rt	PROPN
admet-2387	175	110	retention	retention	NOUN
admet-2387	175	111	time	time	NOUN
admet-2387	175	112	;	;	PUNCT
admet-2387	175	113	dak	dak	PROPN
admet-2387	175	114	deacetyl	deacetyl	VERB
admet-2387	175	115	ketoconazole	ketoconazole	NOUN
admet-2387	175	116	;	;	PUNCT
admet-2387	175	117	the	the	DET
admet-2387	175	118	relative	relative	ADJ
admet-2387	175	119	abundances	abundance	NOUN
admet-2387	175	120	of	of	ADP
admet-2387	175	121	the	the	DET
admet-2387	175	122	parent	parent	NOUN
admet-2387	175	123	and	and	CCONJ
admet-2387	175	124	metabolites	metabolite	NOUN
admet-2387	175	125	were	be	AUX
admet-2387	175	126	calculated	calculate	VERB
admet-2387	175	127	based	base	VERB
admet-2387	175	128	on	on	ADP
admet-2387	175	129	their	their	PRON
admet-2387	175	130	selected	select	VERB
admet-2387	175	131	ion	ion	NOUN
admet-2387	175	132	chromatographic	chromatographic	ADJ
admet-2387	175	133	peak	peak	NOUN
admet-2387	175	134	areas	area	NOUN
admet-2387	175	135	.	.	PUNCT
admet-2387	176	1	conclusion	conclusion	NOUN
admet-2387	176	2	ketoconazole	ketoconazole	PROPN
admet-2387	176	3	exhibited	exhibit	VERB
admet-2387	176	4	higher	high	ADJ
admet-2387	176	5	concentrations	concentration	NOUN
admet-2387	176	6	in	in	ADP
admet-2387	176	7	the	the	DET
admet-2387	176	8	cornea	cornea	NOUN
admet-2387	176	9	,	,	PUNCT
admet-2387	176	10	retina	retina	NOUN
admet-2387	176	11	and	and	CCONJ
admet-2387	176	12	vitreous	vitreous	ADJ
admet-2387	176	13	humour	humour	NOUN
admet-2387	176	14	than	than	ADP
admet-2387	176	15	in	in	ADP
admet-2387	176	16	plasma	plasma	NOUN
admet-2387	176	17	in	in	ADP
admet-2387	176	18	rats	rat	NOUN
admet-2387	176	19	following	follow	VERB
admet-2387	176	20	single	single	ADJ
admet-2387	176	21	topical	topical	ADJ
admet-2387	176	22	ocular	ocular	ADJ
admet-2387	176	23	administration	administration	NOUN
admet-2387	176	24	.	.	PUNCT
admet-2387	177	1	the	the	DET
admet-2387	177	2	mean	mean	ADJ
admet-2387	177	3	ketoconazole	ketoconazole	NOUN
admet-2387	177	4	concentration	concentration	NOUN
admet-2387	177	5	in	in	ADP
admet-2387	177	6	each	each	DET
admet-2387	177	7	tissue	tissue	NOUN
admet-2387	177	8	decreased	decrease	VERB
admet-2387	177	9	from	from	ADP
admet-2387	177	10	5	5	NUM
admet-2387	177	11	to	to	PART
admet-2387	177	12	120	120	NUM
admet-2387	177	13	min	min	NOUN
admet-2387	177	14	.	.	PUNCT
admet-2387	178	1	the	the	DET
admet-2387	178	2	observed	observe	VERB
admet-2387	178	3	metabolic	metabolic	NOUN
admet-2387	178	4	pathways	pathway	NOUN
admet-2387	178	5	were	be	AUX
admet-2387	178	6	o	o	NOUN
admet-2387	178	7	-	-	NOUN
admet-2387	178	8	dealkylation	dealkylation	NOUN
admet-2387	178	9	,	,	PUNCT
admet-2387	178	10	mono	mono	NOUN
admet-2387	178	11	-	-	PUNCT
admet-2387	178	12	oxygenation	oxygenation	NOUN
admet-2387	178	13	,	,	PUNCT
admet-2387	178	14	and	and	CCONJ
admet-2387	178	15	dehydrogenation	dehydrogenation	NOUN
admet-2387	178	16	.	.	PUNCT
admet-2387	179	1	nine	nine	NUM
admet-2387	179	2	metabolites	metabolite	NOUN
admet-2387	179	3	were	be	AUX
admet-2387	179	4	identified	identify	VERB
admet-2387	179	5	in	in	ADP
admet-2387	179	6	rat	rat	NOUN
admet-2387	179	7	plasma	plasma	NOUN
admet-2387	179	8	,	,	PUNCT
admet-2387	179	9	and	and	CCONJ
admet-2387	179	10	the	the	DET
admet-2387	179	11	o	o	ADJ
admet-2387	179	12	-	-	ADJ
admet-2387	179	13	dealkylated	dealkylated	ADJ
admet-2387	179	14	metabolite	metabolite	NOUN
admet-2387	179	15	(	(	PUNCT
admet-2387	179	16	m3	m3	PROPN
admet-2387	179	17	)	)	PUNCT
admet-2387	179	18	and	and	CCONJ
admet-2387	179	19	dehydrogenated	dehydrogenated	ADJ
admet-2387	179	20	metabolite	metabolite	NOUN
admet-2387	179	21	(	(	PUNCT
admet-2387	179	22	m11	m11	NOUN
admet-2387	179	23	)	)	PUNCT
admet-2387	179	24	were	be	AUX
admet-2387	179	25	top	top	ADJ
admet-2387	179	26	two	two	NUM
admet-2387	179	27	abundant	abundant	ADJ
admet-2387	179	28	metabolites	metabolite	NOUN
admet-2387	179	29	,	,	PUNCT
admet-2387	179	30	accounting	account	VERB
admet-2387	179	31	for	for	ADP
admet-2387	179	32	5.0	5.0	NUM
admet-2387	179	33	and	and	CCONJ
admet-2387	179	34	5.8	5.8	NUM
admet-2387	179	35	%	%	NOUN
admet-2387	179	36	of	of	ADP
admet-2387	179	37	the	the	DET
admet-2387	179	38	total	total	ADJ
admet-2387	179	39	mass	mass	PROPN
admet-2387	179	40	abundance	abundance	NOUN
admet-2387	179	41	,	,	PUNCT
admet-2387	179	42	respectively	respectively	ADV
admet-2387	179	43	.	.	PUNCT
admet-2387	180	1	eleven	eleven	NUM
admet-2387	180	2	metabolites	metabolite	NOUN
admet-2387	180	3	were	be	AUX
admet-2387	180	4	identified	identify	VERB
admet-2387	180	5	in	in	ADP
admet-2387	180	6	the	the	DET
admet-2387	180	7	rat	rat	NOUN
admet-2387	180	8	cornea	cornea	NOUN
admet-2387	180	9	,	,	PUNCT
admet-2387	180	10	and	and	CCONJ
admet-2387	180	11	two	two	NUM
admet-2387	180	12	metabolites	metabolite	NOUN
admet-2387	180	13	were	be	AUX
admet-2387	180	14	detected	detect	VERB
admet-2387	180	15	in	in	ADP
admet-2387	180	16	the	the	DET
admet-2387	180	17	rat	rat	NOUN
admet-2387	180	18	retina	retina	NOUN
admet-2387	180	19	and	and	CCONJ
admet-2387	180	20	vitreous	vitreous	ADJ
admet-2387	180	21	humour	humour	NOUN
admet-2387	180	22	,	,	PUNCT
admet-2387	180	23	respectively	respectively	ADV
admet-2387	180	24	.	.	PUNCT
admet-2387	181	1	the	the	DET
admet-2387	181	2	o	o	NOUN
admet-2387	181	3	-	-	ADJ
admet-2387	181	4	dealkylated	dealkylated	ADJ
admet-2387	181	5	and	and	CCONJ
admet-2387	181	6	hydrogenated	hydrogenated	ADJ
admet-2387	181	7	metabolite	metabolite	NOUN
admet-2387	181	8	(	(	PUNCT
admet-2387	181	9	m2	m2	PROPN
admet-2387	181	10	)	)	PUNCT
admet-2387	181	11	was	be	AUX
admet-2387	181	12	a	a	DET
admet-2387	181	13	dominant	dominant	ADJ
admet-2387	181	14	metabolite	metabolite	NOUN
admet-2387	181	15	in	in	ADP
admet-2387	181	16	the	the	DET
admet-2387	181	17	cornea	cornea	NOUN
admet-2387	181	18	,	,	PUNCT
admet-2387	181	19	retina	retina	NOUN
admet-2387	181	20	,	,	PUNCT
admet-2387	181	21	and	and	CCONJ
admet-2387	181	22	vitreous	vitreous	ADJ
admet-2387	181	23	humour	humour	NOUN
admet-2387	181	24	,	,	PUNCT
admet-2387	181	25	while	while	SCONJ
admet-2387	181	26	m3	m3	PROPN
admet-2387	181	27	and	and	CCONJ
admet-2387	181	28	m11	m11	PROPN
admet-2387	181	29	were	be	AUX
admet-2387	181	30	the	the	DET
admet-2387	181	31	dominant	dominant	ADJ
admet-2387	181	32	metabolites	metabolite	NOUN
admet-2387	181	33	in	in	ADP
admet-2387	181	34	plasma	plasma	NOUN
admet-2387	181	35	.	.	PUNCT
admet-2387	182	1	no	no	DET
admet-2387	182	2	n	n	ADV
admet-2387	182	3	-	-	PUNCT
admet-2387	182	4	deacetyl	deacetyl	NOUN
admet-2387	182	5	ketoconazole	ketoconazole	NOUN
admet-2387	182	6	(	(	PUNCT
admet-2387	182	7	m4	m4	PROPN
admet-2387	182	8	)	)	PUNCT
admet-2387	182	9	was	be	AUX
admet-2387	182	10	found	find	VERB
admet-2387	182	11	in	in	ADP
admet-2387	182	12	the	the	DET
admet-2387	182	13	plasma	plasma	NOUN
admet-2387	182	14	.	.	PUNCT
admet-2387	183	1	acknowledgement	acknowledgement	NOUN
admet-2387	183	2	:	:	PUNCT
admet-2387	183	3	the	the	DET
admet-2387	183	4	authors	author	NOUN
admet-2387	183	5	express	express	VERB
admet-2387	183	6	special	special	ADJ
admet-2387	183	7	thanks	thank	NOUN
admet-2387	183	8	to	to	ADP
admet-2387	183	9	xiaona	xiaona	PROPN
admet-2387	183	10	duan	duan	PROPN
admet-2387	183	11	,	,	PUNCT
admet-2387	183	12	wenying	wenye	VERB
admet-2387	183	13	sun	sun	NOUN
admet-2387	183	14	and	and	CCONJ
admet-2387	183	15	weimin	weimin	PROPN
admet-2387	183	16	yuan	yuan	PROPN
admet-2387	183	17	for	for	ADP
admet-2387	183	18	their	their	PRON
admet-2387	183	19	support	support	NOUN
admet-2387	183	20	during	during	ADP
admet-2387	183	21	sample	sample	NOUN
admet-2387	183	22	generation	generation	NOUN
admet-2387	183	23	and	and	CCONJ
admet-2387	183	24	sample	sample	NOUN
admet-2387	183	25	analysis	analysis	NOUN
admet-2387	183	26	.	.	PUNCT
admet-2387	184	1	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	184	2	j.	j.	PROPN
admet-2387	184	3	pu	pu	PROPN
admet-2387	184	4	et	et	PROPN
admet-2387	184	5	al	al	PROPN
admet-2387	184	6	.	.	PROPN
admet-2387	184	7	admet	admet	PROPN
admet-2387	184	8	&	&	CCONJ
admet-2387	184	9	dmpk	dmpk	PROPN
admet-2387	184	10	12(6	12(6	NUM
admet-2387	184	11	)	)	PUNCT
admet-2387	184	12	(	(	PUNCT
admet-2387	184	13	2024	2024	NUM
admet-2387	184	14	)	)	PUNCT
admet-2387	184	15	943	943	NUM
admet-2387	184	16	-	-	SYM
admet-2387	184	17	955	955	NUM
admet-2387	184	18	952	952	NUM
admet-2387	184	19	ethical	ethical	ADJ
admet-2387	184	20	statement	statement	NOUN
admet-2387	184	21	:	:	PUNCT
admet-2387	184	22	all	all	DET
admet-2387	184	23	procedures	procedure	NOUN
admet-2387	184	24	performed	perform	VERB
admet-2387	184	25	on	on	ADP
admet-2387	184	26	the	the	DET
admet-2387	184	27	animals	animal	NOUN
admet-2387	184	28	were	be	AUX
admet-2387	184	29	in	in	ADP
admet-2387	184	30	accordance	accordance	NOUN
admet-2387	184	31	with	with	ADP
admet-2387	184	32	regulations	regulation	NOUN
admet-2387	184	33	and	and	CCONJ
admet-2387	184	34	established	establish	VERB
admet-2387	184	35	guidelines	guideline	NOUN
admet-2387	184	36	and	and	CCONJ
admet-2387	184	37	were	be	AUX
admet-2387	184	38	reviewed	review	VERB
admet-2387	184	39	and	and	CCONJ
admet-2387	184	40	approved	approve	VERB
admet-2387	184	41	by	by	ADP
admet-2387	184	42	an	an	DET
admet-2387	184	43	institutional	institutional	ADJ
admet-2387	184	44	animal	animal	NOUN
admet-2387	184	45	care	care	NOUN
admet-2387	184	46	and	and	CCONJ
admet-2387	184	47	use	use	VERB
admet-2387	184	48	committee	committee	NOUN
admet-2387	184	49	through	through	ADP
admet-2387	184	50	an	an	DET
admet-2387	184	51	ethical	ethical	ADJ
admet-2387	184	52	review	review	NOUN
admet-2387	184	53	process	process	NOUN
admet-2387	184	54	.	.	PUNCT
admet-2387	185	1	conflict	conflict	NOUN
admet-2387	185	2	of	of	ADP
admet-2387	185	3	interest	interest	NOUN
admet-2387	185	4	:	:	PUNCT
admet-2387	185	5	the	the	DET
admet-2387	185	6	authors	author	NOUN
admet-2387	185	7	have	have	VERB
admet-2387	185	8	no	no	DET
admet-2387	185	9	conflict	conflict	NOUN
admet-2387	185	10	of	of	ADP
admet-2387	185	11	interest	interest	NOUN
admet-2387	185	12	.	.	PUNCT
admet-2387	186	1	funding	funding	NOUN
admet-2387	186	2	:	:	PUNCT
admet-2387	186	3	none	none	NOUN
admet-2387	186	4	references	reference	VERB
admet-2387	186	5	[	[	X
admet-2387	186	6	1	1	NUM
admet-2387	186	7	]	]	X
admet-2387	186	8	m.s	m.s	PROPN
admet-2387	186	9	.	.	PROPN
admet-2387	186	10	marriott	marriott	PROPN
admet-2387	186	11	.	.	PUNCT
admet-2387	187	1	inhibition	inhibition	NOUN
admet-2387	187	2	of	of	ADP
admet-2387	187	3	sterol	sterol	NOUN
admet-2387	187	4	biosynthesis	biosynthesis	NOUN
admet-2387	187	5	in	in	ADP
admet-2387	187	6	candida	candida	NOUN
admet-2387	187	7	albicans	albican	NOUN
admet-2387	187	8	by	by	ADP
admet-2387	187	9	imidazole	imidazole	NOUN
admet-2387	187	10	-	-	PUNCT
admet-2387	187	11	containing	contain	VERB
admet-2387	187	12	antifungals	antifungal	NOUN
admet-2387	187	13	.	.	PUNCT
admet-2387	188	1	journal	journal	NOUN
admet-2387	188	2	of	of	ADP
admet-2387	188	3	general	general	ADJ
admet-2387	188	4	microbiology	microbiology	NOUN
admet-2387	188	5	117	117	NUM
admet-2387	188	6	(	(	PUNCT
admet-2387	188	7	1980	1980	NUM
admet-2387	188	8	)	)	PUNCT
admet-2387	188	9	253	253	NUM
admet-2387	188	10	-	-	SYM
admet-2387	188	11	255	255	NUM
admet-2387	188	12	.	.	PUNCT
admet-2387	189	1	https://doi.org/10.1099/00221287-117-1-253	https://doi.org/10.1099/00221287-117-1-253	X
admet-2387	189	2	.	.	PUNCT
admet-2387	190	1	[	[	X
admet-2387	190	2	2	2	X
admet-2387	190	3	]	]	X
admet-2387	190	4	d.	d.	PROPN
admet-2387	190	5	allen	allen	PROPN
admet-2387	190	6	,	,	PUNCT
admet-2387	190	7	d.	d.	PROPN
admet-2387	190	8	wilson	wilson	PROPN
admet-2387	190	9	,	,	PUNCT
admet-2387	190	10	r.	r.	PROPN
admet-2387	190	11	drew	draw	VERB
admet-2387	190	12	,	,	PUNCT
admet-2387	190	13	j.	j.	PROPN
admet-2387	190	14	perfect	perfect	PROPN
admet-2387	190	15	.	.	PUNCT
admet-2387	191	1	expert	expert	NOUN
admet-2387	191	2	review	review	NOUN
admet-2387	191	3	of	of	ADP
admet-2387	191	4	anti	anti	ADJ
admet-2387	191	5	-	-	ADJ
admet-2387	191	6	infective	infective	ADJ
admet-2387	191	7	therapy	therapy	NOUN
admet-2387	191	8	infection	infection	NOUN
admet-2387	191	9	management	management	NOUN
admet-2387	191	10	azole	azole	NOUN
admet-2387	191	11	antifungals	antifungal	NOUN
admet-2387	191	12	:	:	PUNCT
admet-2387	191	13	35	35	NUM
admet-2387	191	14	years	year	NOUN
admet-2387	191	15	of	of	ADP
admet-2387	191	16	invasive	invasive	ADJ
admet-2387	191	17	fungal	fungal	ADJ
admet-2387	191	18	infection	infection	NOUN
admet-2387	191	19	management	management	NOUN
admet-2387	191	20	.	.	PUNCT
admet-2387	192	1	expert	expert	NOUN
admet-2387	192	2	review	review	PROPN
admet-2387	192	3	of	of	ADP
admet-2387	192	4	anti	anti	ADJ
admet-2387	192	5	-	-	ADJ
admet-2387	192	6	infective	infective	ADJ
admet-2387	192	7	therapy	therapy	NOUN
admet-2387	192	8	13	13	NUM
admet-2387	192	9	(	(	PUNCT
admet-2387	192	10	2015	2015	NUM
admet-2387	192	11	)	)	PUNCT
admet-2387	192	12	787	787	NUM
admet-2387	192	13	-	-	SYM
admet-2387	192	14	798	798	NUM
admet-2387	192	15	.	.	PUNCT
admet-2387	193	1	http://doi.org/10.1586/14787210.2015.1032939	http://doi.org/10.1586/14787210.2015.1032939	PROPN
admet-2387	193	2	.	.	PUNCT
admet-2387	194	1	[	[	X
admet-2387	194	2	3	3	X
admet-2387	194	3	]	]	X
admet-2387	194	4	g.	g.	PROPN
admet-2387	194	5	larralde	larralde	PROPN
admet-2387	194	6	,	,	PUNCT
admet-2387	194	7	j.	j.	PROPN
admet-2387	194	8	vivas	vivas	PROPN
admet-2387	194	9	,	,	PUNCT
admet-2387	194	10	j.a	j.a	PROPN
admet-2387	194	11	.	.	PROPN
admet-2387	194	12	urbina	urbina	PROPN
admet-2387	194	13	.	.	PROPN
admet-2387	195	1	concentration	concentration	NOUN
admet-2387	195	2	and	and	CCONJ
admet-2387	195	3	time	time	NOUN
admet-2387	195	4	dependence	dependence	NOUN
admet-2387	195	5	of	of	ADP
admet-2387	195	6	the	the	DET
admet-2387	195	7	effects	effect	NOUN
admet-2387	195	8	of	of	ADP
admet-2387	195	9	ketoconazole	ketoconazole	NOUN
admet-2387	195	10	on	on	ADP
admet-2387	195	11	growth	growth	NOUN
admet-2387	195	12	and	and	CCONJ
admet-2387	195	13	sterol	sterol	NOUN
admet-2387	195	14	synthesis	synthesis	NOUN
admet-2387	195	15	by	by	ADP
admet-2387	195	16	trypanosoma	trypanosoma	NOUN
admet-2387	195	17	(	(	PUNCT
admet-2387	195	18	schizotrypanum	schizotrypanum	PROPN
admet-2387	195	19	)	)	PUNCT
admet-2387	195	20	cruzi	cruzi	PROPN
admet-2387	195	21	epimastigotes	epimastigotes	PROPN
admet-2387	195	22	.	.	PUNCT
admet-2387	196	1	acta	acta	PROPN
admet-2387	196	2	cientifica	cientifica	PROPN
admet-2387	196	3	venezolana	venezolana	PROPN
admet-2387	196	4	39	39	NUM
admet-2387	196	5	(	(	PUNCT
admet-2387	196	6	1988	1988	NUM
admet-2387	196	7	)	)	PUNCT
admet-2387	196	8	140	140	NUM
admet-2387	196	9	-	-	SYM
admet-2387	196	10	146	146	NUM
admet-2387	196	11	.	.	PUNCT
admet-2387	197	1	https://pubmed.ncbi.nlm.nih.gov/3075103/.	https://pubmed.ncbi.nlm.nih.gov/3075103/.	CCONJ
admet-2387	197	2	[	[	X
admet-2387	197	3	4	4	X
admet-2387	197	4	]	]	X
admet-2387	197	5	t.k	t.k	PROPN
admet-2387	197	6	.	.	PROPN
admet-2387	197	7	daneshmend	daneshmend	PROPN
admet-2387	197	8	,	,	PUNCT
admet-2387	197	9	d.w	d.w	PROPN
admet-2387	197	10	.	.	PROPN
admet-2387	197	11	warnock	warnock	PROPN
admet-2387	197	12	.	.	PUNCT
admet-2387	198	1	clinical	clinical	ADJ
admet-2387	198	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	198	3	of	of	ADP
admet-2387	198	4	ketoconazole	ketoconazole	NOUN
admet-2387	198	5	.	.	PUNCT
admet-2387	199	1	clinical	clinical	ADJ
admet-2387	199	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	199	3	14	14	NUM
admet-2387	199	4	(	(	PUNCT
admet-2387	199	5	1988	1988	NUM
admet-2387	199	6	)	)	PUNCT
admet-2387	199	7	14	14	NUM
admet-2387	199	8	-	-	SYM
admet-2387	199	9	34	34	NUM
admet-2387	199	10	.	.	PUNCT
admet-2387	199	11	http://doi.org/10.2165/00003088-198814010-00002	http://doi.org/10.2165/00003088-198814010-00002	NOUN
admet-2387	199	12	.	.	PUNCT
admet-2387	200	1	[	[	X
admet-2387	200	2	5	5	X
admet-2387	200	3	]	]	X
admet-2387	200	4	ketoconazole	ketoconazole	PROPN
admet-2387	200	5	hra	hra	PROPN
admet-2387	200	6	200	200	NUM
admet-2387	200	7	mg	mg	PROPN
admet-2387	200	8	tablets	tablet	NOUN
admet-2387	200	9	.	.	PUNCT
admet-2387	201	1	electronic	electronic	ADJ
admet-2387	201	2	medicines	medicine	NOUN
admet-2387	201	3	compendium	compendium	NOUN
admet-2387	201	4	.	.	PUNCT
admet-2387	202	1	https://www.medicines.org.uk/emc/product/1767/smpc	https://www.medicines.org.uk/emc/product/1767/smpc	PROPN
admet-2387	202	2	accessed	access	VERB
admet-2387	202	3	november	november	PROPN
admet-2387	202	4	7	7	NUM
admet-2387	202	5	,	,	PUNCT
admet-2387	202	6	2024	2024	NUM
admet-2387	202	7	[	[	X
admet-2387	202	8	6	6	NUM
admet-2387	202	9	]	]	PUNCT
admet-2387	202	10	drug	drug	NOUN
admet-2387	202	11	development	development	NOUN
admet-2387	202	12	and	and	CCONJ
admet-2387	202	13	drug	drug	NOUN
admet-2387	202	14	interactions	interaction	NOUN
admet-2387	202	15	table	table	NOUN
admet-2387	202	16	of	of	ADP
admet-2387	202	17	substrates	substrate	NOUN
admet-2387	202	18	,	,	PUNCT
admet-2387	202	19	inhibitors	inhibitor	NOUN
admet-2387	202	20	and	and	CCONJ
admet-2387	202	21	inducers	inducer	NOUN
admet-2387	202	22	.	.	PUNCT
admet-2387	203	1	u.s	u.s	PROPN
admet-2387	203	2	.	.	PROPN
admet-2387	203	3	food	food	PROPN
admet-2387	203	4	&	&	CCONJ
admet-2387	203	5	drug	drug	PROPN
admet-2387	203	6	.	.	PUNCT
admet-2387	204	1	https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-druginteractions-table-substrates-inhibitors-and-inducers	https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-druginteractions-table-substrates-inhibitors-and-inducer	NOUN
admet-2387	204	2	accessed	access	VERB
admet-2387	204	3	november	november	PROPN
admet-2387	204	4	7	7	NUM
admet-2387	204	5	,	,	PUNCT
admet-2387	204	6	2024	2024	NUM
admet-2387	205	1	[	[	X
admet-2387	205	2	7	7	X
admet-2387	205	3	]	]	X
admet-2387	205	4	b.h.c	b.h.c	PROPN
admet-2387	205	5	.	.	PUNCT
admet-2387	205	6	stricker	stricker	PROPN
admet-2387	205	7	,	,	PUNCT
admet-2387	205	8	a.p.r	a.p.r	X
admet-2387	205	9	.	.	PUNCT
admet-2387	206	1	blok	blok	PROPN
admet-2387	206	2	,	,	PUNCT
admet-2387	206	3	f.b	f.b	PROPN
admet-2387	206	4	.	.	PROPN
admet-2387	206	5	bronkhorst	bronkhorst	PROPN
admet-2387	206	6	,	,	PUNCT
admet-2387	206	7	g.e	g.e	PROPN
admet-2387	206	8	.	.	PROPN
admet-2387	207	1	van	van	PROPN
admet-2387	207	2	parys	parys	PROPN
admet-2387	207	3	,	,	PUNCT
admet-2387	207	4	v.j	v.j	PROPN
admet-2387	207	5	.	.	PROPN
admet-2387	207	6	desmet	desmet	PROPN
admet-2387	207	7	.	.	PUNCT
admet-2387	208	1	ketoconazole	ketoconazole	NOUN
admet-2387	208	2	-	-	PUNCT
admet-2387	208	3	associated	associate	VERB
admet-2387	208	4	hepatic	hepatic	ADJ
admet-2387	208	5	injury	injury	NOUN
admet-2387	208	6	.	.	PUNCT
admet-2387	209	1	a	a	DET
admet-2387	209	2	clinicopathological	clinicopathological	ADJ
admet-2387	209	3	study	study	NOUN
admet-2387	209	4	of	of	ADP
admet-2387	209	5	55	55	NUM
admet-2387	209	6	cases	case	NOUN
admet-2387	209	7	.	.	PUNCT
admet-2387	210	1	journal	journal	NOUN
admet-2387	210	2	of	of	ADP
admet-2387	210	3	hepatology	hepatology	NOUN
admet-2387	210	4	3	3	NUM
admet-2387	210	5	(	(	PUNCT
admet-2387	210	6	1986	1986	NUM
admet-2387	210	7	)	)	PUNCT
admet-2387	210	8	399	399	NUM
admet-2387	210	9	-	-	SYM
admet-2387	210	10	406	406	NUM
admet-2387	210	11	.	.	PUNCT
admet-2387	211	1	http://doi.org/10.1016/s0168-8278(86)80495-0	http://doi.org/10.1016/s0168-8278(86)80495-0	PROPN
admet-2387	211	2	.	.	PUNCT
admet-2387	212	1	[	[	X
admet-2387	212	2	8	8	NUM
admet-2387	212	3	]	]	X
admet-2387	212	4	j.h	j.h	PROPN
admet-2387	212	5	.	.	PROPN
admet-2387	212	6	lewis	lewis	PROPN
admet-2387	212	7	,	,	PUNCT
admet-2387	212	8	h.j	h.j	PROPN
admet-2387	212	9	.	.	PROPN
admet-2387	212	10	zimmerman	zimmerman	PROPN
admet-2387	212	11	,	,	PUNCT
admet-2387	212	12	g.d	g.d	PROPN
admet-2387	212	13	.	.	PROPN
admet-2387	212	14	benson	benson	PROPN
admet-2387	212	15	,	,	PUNCT
admet-2387	212	16	k.g	k.g	PROPN
admet-2387	212	17	.	.	PROPN
admet-2387	212	18	ishak	ishak	PROPN
admet-2387	212	19	.	.	PUNCT
admet-2387	213	1	hepatic	hepatic	ADJ
admet-2387	213	2	injury	injury	NOUN
admet-2387	213	3	associated	associate	VERB
admet-2387	213	4	with	with	ADP
admet-2387	213	5	ketoconazole	ketoconazole	NOUN
admet-2387	213	6	therapy	therapy	NOUN
admet-2387	213	7	:	:	PUNCT
admet-2387	213	8	analysis	analysis	NOUN
admet-2387	213	9	of	of	ADP
admet-2387	213	10	33	33	NUM
admet-2387	213	11	cases	case	NOUN
admet-2387	213	12	.	.	PUNCT
admet-2387	214	1	gastroenterology	gastroenterology	NOUN
admet-2387	214	2	86	86	NUM
admet-2387	214	3	(	(	PUNCT
admet-2387	214	4	1984	1984	NUM
admet-2387	214	5	)	)	PUNCT
admet-2387	214	6	503	503	NUM
admet-2387	214	7	-	-	SYM
admet-2387	214	8	513	513	NUM
admet-2387	214	9	.	.	PUNCT
admet-2387	214	10	http://doi.org/10.1016/s00165085(84)80021-9	http://doi.org/10.1016/s00165085(84)80021-9	NOUN
admet-2387	214	11	.	.	PUNCT
admet-2387	215	1	[	[	X
admet-2387	215	2	9	9	NUM
admet-2387	215	3	]	]	X
admet-2387	215	4	p.s	p.s	PROPN
admet-2387	215	5	.	.	PROPN
admet-2387	215	6	banankhah	banankhah	PROPN
admet-2387	215	7	,	,	PUNCT
admet-2387	215	8	k.a	k.a	PROPN
admet-2387	215	9	.	.	PROPN
admet-2387	215	10	garnick	garnick	PROPN
admet-2387	215	11	,	,	PUNCT
admet-2387	215	12	d.j	d.j	PROPN
admet-2387	215	13	.	.	PROPN
admet-2387	215	14	greenblatt	greenblatt	PROPN
admet-2387	215	15	.	.	PUNCT
admet-2387	216	1	ketoconazole	ketoconazole	PROPN
admet-2387	216	2	-	-	PUNCT
admet-2387	216	3	associated	associate	VERB
admet-2387	216	4	liver	liver	NOUN
admet-2387	216	5	injury	injury	NOUN
admet-2387	216	6	in	in	ADP
admet-2387	216	7	drug	drug	NOUN
admet-2387	216	8	-	-	PUNCT
admet-2387	216	9	drug	drug	NOUN
admet-2387	216	10	interaction	interaction	NOUN
admet-2387	216	11	studies	study	NOUN
admet-2387	216	12	in	in	ADP
admet-2387	216	13	healthy	healthy	ADJ
admet-2387	216	14	volunteers	volunteer	NOUN
admet-2387	216	15	.	.	PUNCT
admet-2387	217	1	journal	journal	NOUN
admet-2387	217	2	of	of	ADP
admet-2387	217	3	clinical	clinical	ADJ
admet-2387	217	4	pharmacology	pharmacology	NOUN
admet-2387	217	5	56	56	NUM
admet-2387	217	6	(	(	PUNCT
admet-2387	217	7	2016	2016	NUM
admet-2387	217	8	)	)	PUNCT
admet-2387	217	9	1196	1196	NUM
admet-2387	217	10	-	-	SYM
admet-2387	217	11	1202	1202	NUM
admet-2387	217	12	.	.	PUNCT
admet-2387	218	1	http://doi.org/10.1002/jcph.711	http://doi.org/10.1002/jcph.711	NOUN
admet-2387	218	2	.	.	PUNCT
admet-2387	219	1	[	[	X
admet-2387	219	2	10	10	NUM
admet-2387	219	3	]	]	X
admet-2387	219	4	h.k	h.k	PROPN
admet-2387	219	5	.	.	PROPN
admet-2387	219	6	greenblatt	greenblatt	PROPN
admet-2387	219	7	,	,	PUNCT
admet-2387	219	8	d.j	d.j	PROPN
admet-2387	219	9	.	.	PROPN
admet-2387	219	10	greenblatt	greenblatt	PROPN
admet-2387	219	11	.	.	PUNCT
admet-2387	220	1	liver	liver	NOUN
admet-2387	220	2	injury	injury	NOUN
admet-2387	220	3	associated	associate	VERB
admet-2387	220	4	with	with	ADP
admet-2387	220	5	ketoconazole	ketoconazole	NOUN
admet-2387	220	6	:	:	PUNCT
admet-2387	220	7	review	review	NOUN
admet-2387	220	8	of	of	ADP
admet-2387	220	9	the	the	DET
admet-2387	220	10	published	publish	VERB
admet-2387	220	11	evidence	evidence	NOUN
admet-2387	220	12	.	.	PUNCT
admet-2387	221	1	journal	journal	NOUN
admet-2387	221	2	of	of	ADP
admet-2387	221	3	clinical	clinical	ADJ
admet-2387	221	4	pharmacology	pharmacology	NOUN
admet-2387	221	5	54	54	NUM
admet-2387	221	6	(	(	PUNCT
admet-2387	221	7	2014	2014	NUM
admet-2387	221	8	)	)	PUNCT
admet-2387	221	9	1321	1321	NUM
admet-2387	221	10	-	-	SYM
admet-2387	221	11	1329	1329	NUM
admet-2387	221	12	.	.	PUNCT
admet-2387	222	1	http://doi.org/10.1002/jcph.400	http://doi.org/10.1002/jcph.400	NOUN
admet-2387	222	2	.	.	PUNCT
admet-2387	223	1	[	[	X
admet-2387	223	2	11	11	NUM
admet-2387	223	3	]	]	X
admet-2387	223	4	r.j	r.j	PROPN
admet-2387	223	5	.	.	PROPN
admet-2387	223	6	rodriguez	rodriguez	PROPN
admet-2387	223	7	,	,	PUNCT
admet-2387	223	8	d.j	d.j	PROPN
admet-2387	223	9	.	.	PROPN
admet-2387	223	10	acosta	acosta	PROPN
admet-2387	223	11	.	.	PUNCT
admet-2387	224	1	n	n	CCONJ
admet-2387	224	2	-	-	PUNCT
admet-2387	224	3	deacetyl	deacetyl	NOUN
admet-2387	224	4	ketoconazole	ketoconazole	NOUN
admet-2387	224	5	-	-	PUNCT
admet-2387	224	6	induced	induce	VERB
admet-2387	224	7	hepatotoxicity	hepatotoxicity	NOUN
admet-2387	224	8	in	in	ADP
admet-2387	224	9	a	a	DET
admet-2387	224	10	primary	primary	ADJ
admet-2387	224	11	culture	culture	NOUN
admet-2387	224	12	system	system	NOUN
admet-2387	224	13	of	of	ADP
admet-2387	224	14	rat	rat	NOUN
admet-2387	224	15	hepatocytes	hepatocyte	NOUN
admet-2387	224	16	.	.	PUNCT
admet-2387	225	1	toxicology	toxicology	NOUN
admet-2387	225	2	117	117	NUM
admet-2387	225	3	(	(	PUNCT
admet-2387	225	4	1997	1997	NUM
admet-2387	225	5	)	)	PUNCT
admet-2387	225	6	123	123	NUM
admet-2387	225	7	-	-	SYM
admet-2387	225	8	131	131	NUM
admet-2387	225	9	.	.	PUNCT
admet-2387	226	1	http://doi.org/10.1016/s0300483x(96)03560-3	http://doi.org/10.1016/s0300483x(96)03560-3	PROPN
admet-2387	226	2	.	.	PUNCT
admet-2387	227	1	[	[	X
admet-2387	227	2	12	12	NUM
admet-2387	227	3	]	]	PUNCT
admet-2387	227	4	p.	p.	NOUN
admet-2387	227	5	haegler	haegler	NOUN
admet-2387	227	6	,	,	PUNCT
admet-2387	227	7	l.	l.	PROPN
admet-2387	227	8	joerin	joerin	PROPN
admet-2387	227	9	,	,	PUNCT
admet-2387	227	10	s.	s.	PROPN
admet-2387	227	11	krähenbühl	krähenbühl	PROPN
admet-2387	227	12	,	,	PUNCT
admet-2387	227	13	j.	j.	PROPN
admet-2387	227	14	bouitbir	bouitbir	PROPN
admet-2387	227	15	.	.	PUNCT
admet-2387	228	1	hepatocellular	hepatocellular	ADJ
admet-2387	228	2	toxicity	toxicity	NOUN
admet-2387	228	3	of	of	ADP
admet-2387	228	4	imidazole	imidazole	NOUN
admet-2387	228	5	and	and	CCONJ
admet-2387	228	6	triazole	triazole	ADJ
admet-2387	228	7	antimycotic	antimycotic	ADJ
admet-2387	228	8	agents	agent	NOUN
admet-2387	228	9	.	.	PUNCT
admet-2387	229	1	toxicological	toxicological	ADJ
admet-2387	229	2	sciences	science	NOUN
admet-2387	229	3	157	157	NUM
admet-2387	229	4	(	(	PUNCT
admet-2387	229	5	2017	2017	NUM
admet-2387	229	6	)	)	PUNCT
admet-2387	229	7	183	183	NUM
admet-2387	229	8	-	-	SYM
admet-2387	229	9	195	195	NUM
admet-2387	229	10	.	.	PUNCT
admet-2387	229	11	http://doi.org/10.1093/toxsci/kfx029	http://doi.org/10.1093/toxsci/kfx029	NOUN
admet-2387	229	12	.	.	PUNCT
admet-2387	230	1	[	[	X
admet-2387	230	2	13	13	NUM
admet-2387	230	3	]	]	X
admet-2387	230	4	r.j	r.j	PROPN
admet-2387	230	5	.	.	PROPN
admet-2387	230	6	rodriguez	rodriguez	PROPN
admet-2387	230	7	,	,	PUNCT
admet-2387	230	8	c.l	c.l	PROPN
admet-2387	230	9	.	.	PROPN
admet-2387	230	10	miranda	miranda	PROPN
admet-2387	230	11	.	.	PUNCT
admet-2387	231	1	isoform	isoform	NOUN
admet-2387	231	2	specificity	specificity	NOUN
admet-2387	231	3	of	of	ADP
admet-2387	231	4	n	n	CCONJ
admet-2387	231	5	-	-	PUNCT
admet-2387	231	6	deacetyl	deacetyl	NOUN
admet-2387	231	7	ketoconazole	ketoconazole	NOUN
admet-2387	231	8	by	by	ADP
admet-2387	231	9	human	human	ADJ
admet-2387	231	10	and	and	CCONJ
admet-2387	231	11	rabbit	rabbit	NOUN
admet-2387	231	12	flavin	flavin	NOUN
admet-2387	231	13	-	-	PUNCT
admet-2387	231	14	containing	contain	VERB
admet-2387	231	15	monooxygenases	monooxygenase	NOUN
admet-2387	231	16	.	.	PUNCT
admet-2387	232	1	drug	drug	NOUN
admet-2387	232	2	metabolism	metabolism	NOUN
admet-2387	232	3	and	and	CCONJ
admet-2387	232	4	disposition	disposition	NOUN
admet-2387	232	5	28(9	28(9	NOUN
admet-2387	232	6	)	)	PUNCT
admet-2387	232	7	(	(	PUNCT
admet-2387	232	8	2000	2000	NUM
admet-2387	232	9	)	)	PUNCT
admet-2387	232	10	1083	1083	NUM
admet-2387	232	11	-	-	SYM
admet-2387	232	12	1086	1086	NUM
admet-2387	232	13	.	.	PUNCT
admet-2387	233	1	https://dmd.aspetjournals.org/content/28/9/1083	https://dmd.aspetjournals.org/content/28/9/1083	X
admet-2387	234	1	[	[	X
admet-2387	234	2	14	14	NUM
admet-2387	234	3	]	]	X
admet-2387	234	4	j.	j.	PROPN
admet-2387	234	5	weiss	weiss	PROPN
admet-2387	234	6	,	,	PUNCT
admet-2387	234	7	k.i	k.i	PROPN
admet-2387	234	8	.	.	PUNCT
admet-2387	234	9	foerster	foerster	PROPN
admet-2387	234	10	,	,	PUNCT
admet-2387	234	11	m.	m.	PROPN
admet-2387	234	12	weber	weber	PROPN
admet-2387	234	13	,	,	PUNCT
admet-2387	234	14	j.	j.	PROPN
admet-2387	234	15	burhenne	burhenne	PROPN
admet-2387	234	16	,	,	PUNCT
admet-2387	234	17	g.	g.	PROPN
admet-2387	234	18	mikus	mikus	PROPN
admet-2387	234	19	,	,	PUNCT
admet-2387	234	20	t.	t.	NOUN
admet-2387	234	21	lehr	lehr	PROPN
admet-2387	234	22	,	,	PUNCT
admet-2387	234	23	w.e	w.e	PROPN
admet-2387	234	24	.	.	PROPN
admet-2387	234	25	haefeli	haefeli	PROPN
admet-2387	234	26	.	.	PUNCT
admet-2387	235	1	does	do	AUX
admet-2387	235	2	the	the	DET
admet-2387	235	3	circulating	circulate	VERB
admet-2387	235	4	ketoconazole	ketoconazole	NOUN
admet-2387	235	5	metabolite	metabolite	NOUN
admet-2387	235	6	n	n	CCONJ
admet-2387	235	7	-	-	PUNCT
admet-2387	235	8	deacetyl	deacetyl	NOUN
admet-2387	235	9	ketoconazole	ketoconazole	NOUN
admet-2387	235	10	contribute	contribute	VERB
admet-2387	235	11	to	to	ADP
admet-2387	235	12	the	the	DET
admet-2387	235	13	drug	drug	NOUN
admet-2387	235	14	-	-	PUNCT
admet-2387	235	15	drug	drug	NOUN
admet-2387	235	16	interaction	interaction	NOUN
admet-2387	235	17	potential	potential	NOUN
admet-2387	235	18	of	of	ADP
admet-2387	235	19	the	the	DET
admet-2387	235	20	parent	parent	NOUN
admet-2387	235	21	compound	compound	NOUN
admet-2387	235	22	?	?	PUNCT
admet-2387	236	1	european	european	ADJ
admet-2387	236	2	journal	journal	PROPN
admet-2387	236	3	of	of	ADP
admet-2387	236	4	pharmaceutical	pharmaceutical	PROPN
admet-2387	236	5	sciences	science	NOUN
admet-2387	236	6	169	169	NUM
admet-2387	236	7	(	(	PUNCT
admet-2387	236	8	2022	2022	NUM
admet-2387	236	9	)	)	PUNCT
admet-2387	236	10	106076	106076	NUM
admet-2387	236	11	.	.	PUNCT
admet-2387	237	1	http://doi.org/10.1016/j.ejps.2021.106076	http://doi.org/10.1016/j.ejps.2021.106076	ADJ
admet-2387	237	2	.	.	PUNCT
admet-2387	238	1	https://doi.org/10.1099/00221287-117-1-253	https://doi.org/10.1099/00221287-117-1-253	PROPN
admet-2387	239	1	http://doi.org/10.2165/00003088-198814010-00002	http://doi.org/10.2165/00003088-198814010-00002	PROPN
admet-2387	239	2	https://www.medicines.org.uk/emc/product/1767/smpc	https://www.medicines.org.uk/emc/product/1767/smpc	PROPN
admet-2387	239	3	https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers	https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducer	VERB
admet-2387	239	4	https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers	https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducer	VERB
admet-2387	239	5	http://doi.org/10.1016/s0168-8278(86)80495-0	http://doi.org/10.1016/s0168-8278(86)80495-0	PROPN
admet-2387	239	6	http://doi.org/10.1016/s0016-5085(84)80021-9	http://doi.org/10.1016/s0016-5085(84)80021-9	PROPN
admet-2387	239	7	http://doi.org/10.1016/s0016-5085(84)80021-9	http://doi.org/10.1016/s0016-5085(84)80021-9	PROPN
admet-2387	239	8	http://doi.org/10.1002/jcph.711	http://doi.org/10.1002/jcph.711	NOUN
admet-2387	239	9	http://doi.org/10.1002/jcph.400	http://doi.org/10.1002/jcph.400	VERB
admet-2387	239	10	http://doi.org/10.1016/s0300-483x(96)03560-3	http://doi.org/10.1016/s0300-483x(96)03560-3	ADJ
admet-2387	239	11	http://doi.org/10.1016/s0300-483x(96)03560-3	http://doi.org/10.1016/s0300-483x(96)03560-3	ADJ
admet-2387	239	12	http://doi.org/10.1093/toxsci/kfx029	http://doi.org/10.1093/toxsci/kfx029	NOUN
admet-2387	239	13	https://dmd.aspetjournals.org/content/28/9/1083	https://dmd.aspetjournals.org/content/28/9/1083	PRON
admet-2387	239	14	http://doi.org/10.1016/j.ejps.2021.106076	http://doi.org/10.1016/j.ejps.2021.106076	PROPN
admet-2387	239	15	admet	admet	PROPN
admet-2387	239	16	&	&	CCONJ
admet-2387	239	17	dmpk	dmpk	PROPN
admet-2387	239	18	12(6	12(6	NUM
admet-2387	239	19	)	)	PUNCT
admet-2387	239	20	(	(	PUNCT
admet-2387	239	21	2024	2024	NUM
admet-2387	239	22	)	)	PUNCT
admet-2387	239	23	943	943	NUM
admet-2387	239	24	-	-	SYM
admet-2387	239	25	955	955	NUM
admet-2387	239	26	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	239	27	and	and	CCONJ
admet-2387	239	28	metabolism	metabolism	NOUN
admet-2387	239	29	of	of	ADP
admet-2387	239	30	ketoconazole	ketoconazole	PROPN
admet-2387	239	31	doi	doi	PROPN
admet-2387	239	32	:	:	PUNCT
admet-2387	239	33	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	239	34	953	953	NUM
admet-2387	239	35	[	[	X
admet-2387	239	36	15	15	NUM
admet-2387	239	37	]	]	X
admet-2387	239	38	d.j	d.j	PROPN
admet-2387	239	39	.	.	PROPN
admet-2387	239	40	greenblatt	greenblatt	PROPN
admet-2387	239	41	.	.	PUNCT
admet-2387	240	1	the	the	DET
admet-2387	240	2	ketoconazole	ketoconazole	PROPN
admet-2387	240	3	legacy	legacy	NOUN
admet-2387	240	4	.	.	PUNCT
admet-2387	241	1	clinical	clinical	ADJ
admet-2387	241	2	pharmacology	pharmacology	NOUN
admet-2387	241	3	in	in	ADP
admet-2387	241	4	drug	drug	NOUN
admet-2387	241	5	development	development	NOUN
admet-2387	241	6	3	3	NUM
admet-2387	241	7	(	(	PUNCT
admet-2387	241	8	2014	2014	NUM
admet-2387	241	9	)	)	PUNCT
admet-2387	241	10	1	1	NUM
admet-2387	241	11	-	-	SYM
admet-2387	241	12	3	3	NUM
admet-2387	241	13	.	.	PUNCT
admet-2387	241	14	http://doi.org/10.1002/cpdd.100	http://doi.org/10.1002/cpdd.100	PROPN
admet-2387	241	15	.	.	PUNCT
admet-2387	242	1	[	[	X
admet-2387	242	2	16	16	NUM
admet-2387	242	3	]	]	X
admet-2387	242	4	nizoral	nizoral	ADJ
admet-2387	242	5	(	(	PUNCT
admet-2387	242	6	ketoconazole	ketoconazole	NOUN
admet-2387	242	7	):	):	PUNCT
admet-2387	242	8	drug	drug	NOUN
admet-2387	242	9	safety	safety	NOUN
admet-2387	242	10	communicationpotentially	communicationpotentially	ADV
admet-2387	242	11	fatal	fatal	ADJ
admet-2387	242	12	liver	liver	NOUN
admet-2387	242	13	injury	injury	NOUN
admet-2387	242	14	,	,	PUNCT
admet-2387	242	15	risk	risk	NOUN
admet-2387	242	16	of	of	ADP
admet-2387	242	17	drug	drug	NOUN
admet-2387	242	18	interactions	interaction	NOUN
admet-2387	242	19	,	,	PUNCT
admet-2387	242	20	and	and	CCONJ
admet-2387	242	21	adrenal	adrenal	ADJ
admet-2387	242	22	gland	gland	NOUN
admet-2387	242	23	problems	problem	NOUN
admet-2387	242	24	.	.	PUNCT
admet-2387	243	1	clinical	clinical	ADJ
admet-2387	243	2	infectious	infectious	ADJ
admet-2387	243	3	diseases	disease	NOUN
admet-2387	243	4	57	57	NUM
admet-2387	243	5	(	(	PUNCT
admet-2387	243	6	2013	2013	NUM
admet-2387	243	7	)	)	PUNCT
admet-2387	243	8	i	i	PROPN
admet-2387	243	9	-	-	PUNCT
admet-2387	243	10	ii	ii	PROPN
admet-2387	243	11	.	.	PUNCT
admet-2387	244	1	https://doi.org/10.1093/cid/cit548	https://doi.org/10.1093/cid/cit548	PROPN
admet-2387	245	1	[	[	X
admet-2387	245	2	17	17	NUM
admet-2387	245	3	]	]	X
admet-2387	245	4	g.	g.	PROPN
admet-2387	245	5	lake	lake	PROPN
admet-2387	245	6	-	-	PUNCT
admet-2387	245	7	bakaar	bakaar	PROPN
admet-2387	245	8	,	,	PUNCT
admet-2387	245	9	p.j	p.j	PROPN
admet-2387	245	10	.	.	PROPN
admet-2387	245	11	scheuer	scheuer	PROPN
admet-2387	245	12	,	,	PUNCT
admet-2387	245	13	d.s	d.s	PROPN
admet-2387	245	14	.	.	PROPN
admet-2387	245	15	sherlock	sherlock	PROPN
admet-2387	245	16	.	.	PUNCT
admet-2387	246	1	hepatic	hepatic	ADJ
admet-2387	246	2	reactions	reaction	NOUN
admet-2387	246	3	associated	associate	VERB
admet-2387	246	4	with	with	ADP
admet-2387	246	5	ketoconazole	ketoconazole	NOUN
admet-2387	246	6	in	in	ADP
admet-2387	246	7	the	the	DET
admet-2387	246	8	united	united	ADJ
admet-2387	246	9	kingdom	kingdom	PROPN
admet-2387	246	10	.	.	PUNCT
admet-2387	247	1	british	british	ADJ
admet-2387	247	2	medical	medical	PROPN
admet-2387	247	3	journal	journal	PROPN
admet-2387	247	4	(	(	PUNCT
admet-2387	247	5	clinical	clinical	ADJ
admet-2387	247	6	research	research	NOUN
admet-2387	247	7	ed	ed	NOUN
admet-2387	247	8	.	.	PUNCT
admet-2387	247	9	)	)	PUNCT
admet-2387	247	10	294	294	NUM
admet-2387	247	11	(	(	PUNCT
admet-2387	247	12	1987	1987	NUM
admet-2387	247	13	)	)	PUNCT
admet-2387	247	14	419	419	NUM
admet-2387	247	15	-	-	SYM
admet-2387	247	16	422	422	NUM
admet-2387	247	17	.	.	PUNCT
admet-2387	248	1	http://doi.org/10.1136/bmj.294.6569.419	http://doi.org/10.1136/bmj.294.6569.419	X
admet-2387	248	2	.	.	PUNCT
admet-2387	249	1	[	[	X
admet-2387	249	2	18	18	NUM
admet-2387	249	3	]	]	X
admet-2387	249	4	n.	n.	NOUN
admet-2387	249	5	outeiro	outeiro	NOUN
admet-2387	249	6	,	,	PUNCT
admet-2387	249	7	n.	n.	NOUN
admet-2387	249	8	hohmann	hohmann	PROPN
admet-2387	249	9	,	,	PUNCT
admet-2387	249	10	g.	g.	PROPN
admet-2387	249	11	mikus	mikus	PROPN
admet-2387	249	12	.	.	PUNCT
admet-2387	250	1	no	no	DET
admet-2387	250	2	increased	increase	VERB
admet-2387	250	3	risk	risk	NOUN
admet-2387	250	4	of	of	ADP
admet-2387	250	5	ketoconazole	ketoconazole	NOUN
admet-2387	250	6	toxicity	toxicity	NOUN
admet-2387	250	7	in	in	ADP
admet-2387	250	8	drug	drug	NOUN
admet-2387	250	9	-	-	PUNCT
admet-2387	250	10	drug	drug	NOUN
admet-2387	250	11	interaction	interaction	NOUN
admet-2387	250	12	studies	study	NOUN
admet-2387	250	13	.	.	PUNCT
admet-2387	251	1	journal	journal	PROPN
admet-2387	251	2	of	of	ADP
admet-2387	251	3	clinical	clinical	ADJ
admet-2387	251	4	pharmacology	pharmacology	NOUN
admet-2387	251	5	56	56	NUM
admet-2387	251	6	(	(	PUNCT
admet-2387	251	7	2016	2016	NUM
admet-2387	251	8	)	)	PUNCT
admet-2387	251	9	1203	1203	NUM
admet-2387	251	10	-	-	SYM
admet-2387	251	11	1211	1211	NUM
admet-2387	251	12	.	.	PUNCT
admet-2387	252	1	https://doi.org/10.1002/jcph.795	https://doi.org/10.1002/jcph.795	X
admet-2387	252	2	.	.	PUNCT
admet-2387	253	1	[	[	X
admet-2387	253	2	19	19	NUM
admet-2387	253	3	]	]	X
admet-2387	253	4	r.j	r.j	PROPN
admet-2387	253	5	.	.	PROPN
admet-2387	253	6	hay	hay	PROPN
admet-2387	253	7	.	.	PUNCT
admet-2387	254	1	ketoconazole	ketoconazole	PROPN
admet-2387	254	2	:	:	PUNCT
admet-2387	254	3	a	a	DET
admet-2387	254	4	reappraisal	reappraisal	NOUN
admet-2387	254	5	.	.	PUNCT
admet-2387	255	1	british	british	PROPN
admet-2387	255	2	medical	medical	PROPN
admet-2387	255	3	journal	journal	PROPN
admet-2387	255	4	(	(	PUNCT
admet-2387	255	5	clinical	clinical	ADJ
admet-2387	255	6	research	research	NOUN
admet-2387	255	7	ed	ed	NOUN
admet-2387	255	8	.	.	PUNCT
admet-2387	255	9	)	)	PUNCT
admet-2387	255	10	290	290	NUM
admet-2387	255	11	(	(	PUNCT
admet-2387	255	12	1985	1985	NUM
admet-2387	255	13	)	)	PUNCT
admet-2387	255	14	260261	260261	NUM
admet-2387	255	15	.	.	PUNCT
admet-2387	256	1	http://doi.org/10.1136/bmj.290.6464.260	http://doi.org/10.1136/bmj.290.6464.260	NOUN
admet-2387	256	2	.	.	PUNCT
admet-2387	257	1	[	[	X
admet-2387	257	2	20	20	NUM
admet-2387	257	3	]	]	PUNCT
admet-2387	257	4	a.	a.	NOUN
admet-2387	257	5	urtti	urtti	PROPN
admet-2387	257	6	.	.	PUNCT
admet-2387	258	1	challenges	challenge	NOUN
admet-2387	258	2	and	and	CCONJ
admet-2387	258	3	obstacles	obstacle	NOUN
admet-2387	258	4	of	of	ADP
admet-2387	258	5	ocular	ocular	ADJ
admet-2387	258	6	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	258	7	and	and	CCONJ
admet-2387	258	8	drug	drug	NOUN
admet-2387	258	9	delivery	delivery	NOUN
admet-2387	258	10	.	.	PUNCT
admet-2387	259	1	advanced	advanced	ADJ
admet-2387	259	2	drug	drug	NOUN
admet-2387	259	3	delivery	delivery	NOUN
admet-2387	259	4	reviews	review	VERB
admet-2387	259	5	58	58	NUM
admet-2387	259	6	(	(	PUNCT
admet-2387	259	7	2006	2006	NUM
admet-2387	259	8	)	)	PUNCT
admet-2387	259	9	1131	1131	NUM
admet-2387	259	10	-	-	SYM
admet-2387	259	11	1135	1135	NUM
admet-2387	259	12	.	.	PUNCT
admet-2387	260	1	http://doi.org/10.1016/j.addr.2006.07.027	http://doi.org/10.1016/j.addr.2006.07.027	X
admet-2387	260	2	.	.	PUNCT
admet-2387	261	1	[	[	X
admet-2387	261	2	21	21	NUM
admet-2387	261	3	]	]	X
admet-2387	261	4	v.	v.	CCONJ
admet-2387	261	5	agrahari	agrahari	PROPN
admet-2387	261	6	,	,	PUNCT
admet-2387	261	7	a.	a.	PROPN
admet-2387	261	8	mandal	mandal	PROPN
admet-2387	261	9	,	,	PUNCT
admet-2387	261	10	v.	v.	PROPN
admet-2387	261	11	agrahari	agrahari	PROPN
admet-2387	261	12	,	,	PUNCT
admet-2387	261	13	h.m	h.m	PROPN
admet-2387	261	14	.	.	PROPN
admet-2387	261	15	trinh	trinh	PROPN
admet-2387	261	16	,	,	PUNCT
admet-2387	261	17	m.	m.	PROPN
admet-2387	261	18	joseph	joseph	PROPN
admet-2387	261	19	,	,	PUNCT
admet-2387	261	20	a.	a.	NOUN
admet-2387	261	21	ray	ray	PROPN
admet-2387	261	22	,	,	PUNCT
admet-2387	261	23	h.	h.	PROPN
admet-2387	261	24	hadji	hadji	PROPN
admet-2387	261	25	,	,	PUNCT
admet-2387	261	26	r.	r.	PROPN
admet-2387	261	27	mitra	mitra	PROPN
admet-2387	261	28	,	,	PUNCT
admet-2387	261	29	d.	d.	PROPN
admet-2387	261	30	pal	pal	PROPN
admet-2387	261	31	,	,	PUNCT
admet-2387	261	32	a.k	a.k	PROPN
admet-2387	261	33	.	.	PROPN
admet-2387	261	34	mitra	mitra	PROPN
admet-2387	261	35	.	.	PUNCT
admet-2387	262	1	a	a	DET
admet-2387	262	2	comprehensive	comprehensive	ADJ
admet-2387	262	3	insight	insight	NOUN
admet-2387	262	4	on	on	ADP
admet-2387	262	5	ocular	ocular	ADJ
admet-2387	262	6	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	262	7	.	.	PUNCT
admet-2387	263	1	drug	drug	NOUN
admet-2387	263	2	delivery	delivery	NOUN
admet-2387	263	3	and	and	CCONJ
admet-2387	263	4	translational	translational	ADJ
admet-2387	263	5	research	research	NOUN
admet-2387	263	6	6	6	NUM
admet-2387	263	7	(	(	PUNCT
admet-2387	263	8	2016	2016	NUM
admet-2387	263	9	)	)	PUNCT
admet-2387	263	10	735–754	735–754	NUM
admet-2387	263	11	.	.	PUNCT
admet-2387	264	1	http://doi.org/10.1007/s13346-016-0339-2	http://doi.org/10.1007/s13346-016-0339-2	NOUN
admet-2387	264	2	.	.	PUNCT
admet-2387	265	1	[	[	X
admet-2387	265	2	22	22	NUM
admet-2387	265	3	]	]	X
admet-2387	265	4	c.	c.	NOUN
admet-2387	265	5	durairaj	durairaj	VERB
admet-2387	265	6	.	.	PUNCT
admet-2387	266	1	ocular	ocular	ADJ
admet-2387	266	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	266	3	.	.	PUNCT
admet-2387	267	1	handbook	handbook	NOUN
admet-2387	267	2	of	of	ADP
admet-2387	267	3	experimental	experimental	ADJ
admet-2387	267	4	pharmacology	pharmacology	NOUN
admet-2387	267	5	242	242	NUM
admet-2387	267	6	(	(	PUNCT
admet-2387	267	7	2017	2017	NUM
admet-2387	267	8	)	)	PUNCT
admet-2387	267	9	31	31	NUM
admet-2387	267	10	-	-	SYM
admet-2387	267	11	35	35	NUM
admet-2387	267	12	.	.	PUNCT
admet-2387	268	1	http://doi.org/10.1007/164_2016_32	http://doi.org/10.1007/164_2016_32	NOUN
admet-2387	268	2	.	.	PUNCT
admet-2387	269	1	[	[	X
admet-2387	269	2	23	23	NUM
admet-2387	269	3	]	]	PUNCT
admet-2387	269	4	deepta	deepta	NOUN
admet-2387	269	5	ghate	ghate	NOUN
admet-2387	269	6	,	,	PUNCT
admet-2387	269	7	henry	henry	PROPN
admet-2387	269	8	f	f	PROPN
admet-2387	269	9	edelhauser	edelhauser	PROPN
admet-2387	269	10	.	.	PUNCT
admet-2387	270	1	ocular	ocular	ADJ
admet-2387	270	2	drug	drug	NOUN
admet-2387	270	3	delivery	delivery	NOUN
admet-2387	270	4	.	.	PUNCT
admet-2387	271	1	expert	expert	ADJ
admet-2387	271	2	opinion	opinion	NOUN
admet-2387	271	3	on	on	ADP
admet-2387	271	4	drug	drug	NOUN
admet-2387	271	5	delivery	delivery	NOUN
admet-2387	271	6	3	3	NUM
admet-2387	271	7	(	(	PUNCT
admet-2387	271	8	2006	2006	NUM
admet-2387	271	9	)	)	PUNCT
admet-2387	271	10	275	275	NUM
admet-2387	271	11	-	-	SYM
admet-2387	271	12	287	287	NUM
admet-2387	271	13	.	.	PUNCT
admet-2387	272	1	https://doi.org/10.1517/17425247.3.2.275	https://doi.org/10.1517/17425247.3.2.275	PROPN
admet-2387	272	2	.	.	PUNCT
admet-2387	273	1	[	[	X
admet-2387	273	2	24	24	NUM
admet-2387	273	3	]	]	X
admet-2387	273	4	s.	s.	PROPN
admet-2387	273	5	horita	horita	PROPN
admet-2387	273	6	,	,	PUNCT
admet-2387	273	7	m.	m.	PROPN
admet-2387	273	8	watanabe	watanabe	PROPN
admet-2387	273	9	,	,	PUNCT
admet-2387	273	10	m.	m.	NOUN
admet-2387	273	11	katagiri	katagiri	PROPN
admet-2387	273	12	,	,	PUNCT
admet-2387	273	13	h.	h.	PROPN
admet-2387	273	14	nakamura	nakamura	PROPN
admet-2387	273	15	,	,	PUNCT
admet-2387	273	16	h.	h.	PROPN
admet-2387	273	17	haniuda	haniuda	PROPN
admet-2387	273	18	,	,	PUNCT
admet-2387	273	19	t.	t.	PROPN
admet-2387	273	20	nakazato	nakazato	PROPN
admet-2387	273	21	,	,	PUNCT
admet-2387	273	22	y.	y.	PROPN
admet-2387	273	23	kagawa	kagawa	PROPN
admet-2387	273	24	.	.	PUNCT
admet-2387	274	1	species	specie	NOUN
admet-2387	274	2	differences	difference	NOUN
admet-2387	274	3	in	in	ADP
admet-2387	274	4	ocular	ocular	ADJ
admet-2387	274	5	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	274	6	and	and	CCONJ
admet-2387	274	7	pharmacological	pharmacological	ADJ
admet-2387	274	8	activities	activity	NOUN
admet-2387	274	9	of	of	ADP
admet-2387	274	10	regorafenib	regorafenib	NOUN
admet-2387	274	11	and	and	CCONJ
admet-2387	274	12	pazopanib	pazopanib	PROPN
admet-2387	274	13	eye	eye	NOUN
admet-2387	274	14	-	-	PUNCT
admet-2387	274	15	drops	drop	NOUN
admet-2387	274	16	among	among	ADP
admet-2387	274	17	rats	rat	NOUN
admet-2387	274	18	,	,	PUNCT
admet-2387	274	19	rabbits	rabbit	NOUN
admet-2387	274	20	and	and	CCONJ
admet-2387	274	21	monkeys	monkey	NOUN
admet-2387	274	22	.	.	PUNCT
admet-2387	275	1	pharmacology	pharmacology	NOUN
admet-2387	275	2	research	research	NOUN
admet-2387	275	3	and	and	CCONJ
admet-2387	275	4	perspectives	perspective	NOUN
admet-2387	275	5	7	7	NUM
admet-2387	275	6	(	(	PUNCT
admet-2387	275	7	2019	2019	NUM
admet-2387	275	8	)	)	PUNCT
admet-2387	275	9	487	487	NUM
admet-2387	275	10	-	-	SYM
admet-2387	275	11	527	527	NUM
admet-2387	275	12	.	.	PUNCT
admet-2387	276	1	http://doi.org/10.1002/prp2.545	http://doi.org/10.1002/prp2.545	PROPN
admet-2387	276	2	.	.	PUNCT
admet-2387	277	1	[	[	X
admet-2387	277	2	25	25	NUM
admet-2387	277	3	]	]	PUNCT
admet-2387	277	4	a.	a.	NOUN
admet-2387	277	5	fayyaz	fayyaz	NOUN
admet-2387	277	6	,	,	PUNCT
admet-2387	277	7	v.p	v.p	PROPN
admet-2387	277	8	.	.	PROPN
admet-2387	277	9	ranta	ranta	PROPN
admet-2387	277	10	,	,	PUNCT
admet-2387	277	11	e.	e.	PROPN
admet-2387	277	12	toropainen	toropainen	PROPN
admet-2387	277	13	,	,	PUNCT
admet-2387	277	14	k.s	k.s	PROPN
admet-2387	277	15	.	.	PROPN
admet-2387	277	16	vellonen	vellonen	PROPN
admet-2387	277	17	,	,	PUNCT
admet-2387	277	18	g.d.a	g.d.a	PROPN
admet-2387	277	19	.	.	PROPN
admet-2387	277	20	ricci	ricci	PROPN
admet-2387	277	21	,	,	PUNCT
admet-2387	277	22	m.	m.	NOUN
admet-2387	277	23	reinisalo	reinisalo	PROPN
admet-2387	277	24	,	,	PUNCT
admet-2387	277	25	e.m	e.m	PROPN
admet-2387	277	26	.	.	PROPN
admet-2387	277	27	heikkinen	heikkinen	PROPN
admet-2387	277	28	,	,	PUNCT
admet-2387	277	29	i.	i.	PROPN
admet-2387	277	30	gardner	gardner	PROPN
admet-2387	277	31	,	,	PUNCT
admet-2387	277	32	a.	a.	NOUN
admet-2387	277	33	urtti	urtti	PROPN
admet-2387	277	34	,	,	PUNCT
admet-2387	277	35	m.	m.	NOUN
admet-2387	277	36	jamei	jamei	PROPN
admet-2387	277	37	,	,	PUNCT
admet-2387	277	38	e.m	e.m	PROPN
admet-2387	277	39	.	.	PROPN
admet-2387	277	40	del	del	PROPN
admet-2387	277	41	amo	amo	PROPN
admet-2387	277	42	.	.	PROPN
admet-2387	277	43	ocular	ocular	ADJ
admet-2387	277	44	intracameral	intracameral	ADJ
admet-2387	277	45	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	277	46	for	for	ADP
admet-2387	277	47	a	a	DET
admet-2387	277	48	cocktail	cocktail	NOUN
admet-2387	277	49	of	of	ADP
admet-2387	277	50	timolol	timolol	NOUN
admet-2387	277	51	,	,	PUNCT
admet-2387	277	52	betaxolol	betaxolol	NOUN
admet-2387	277	53	,	,	PUNCT
admet-2387	277	54	and	and	CCONJ
admet-2387	277	55	atenolol	atenolol	PROPN
admet-2387	277	56	in	in	ADP
admet-2387	277	57	rabbits	rabbit	NOUN
admet-2387	277	58	.	.	PUNCT
admet-2387	278	1	molecular	molecular	ADJ
admet-2387	278	2	pharmaceutics	pharmaceutic	NOUN
admet-2387	278	3	17	17	NUM
admet-2387	278	4	(	(	PUNCT
admet-2387	278	5	2020	2020	NUM
admet-2387	278	6	)	)	PUNCT
admet-2387	278	7	588	588	NUM
admet-2387	278	8	-	-	SYM
admet-2387	278	9	594	594	NUM
admet-2387	278	10	.	.	PUNCT
admet-2387	278	11	http://doi.org/10.1021/acs.molpharmaceut.9b01024	http://doi.org/10.1021/acs.molpharmaceut.9b01024	NOUN
admet-2387	278	12	.	.	PUNCT
admet-2387	279	1	[	[	X
admet-2387	279	2	26	26	NUM
admet-2387	279	3	]	]	PUNCT
admet-2387	279	4	a.	a.	NOUN
admet-2387	279	5	fayyaz	fayyaz	NOUN
admet-2387	279	6	,	,	PUNCT
admet-2387	279	7	k.s	k.s	PROPN
admet-2387	279	8	.	.	PROPN
admet-2387	279	9	vellonen	vellonen	PROPN
admet-2387	279	10	,	,	PUNCT
admet-2387	279	11	v.p	v.p	PROPN
admet-2387	279	12	.	.	PROPN
admet-2387	279	13	ranta	ranta	PROPN
admet-2387	279	14	,	,	PUNCT
admet-2387	279	15	e.	e.	PROPN
admet-2387	279	16	toropainen	toropainen	PROPN
admet-2387	279	17	,	,	PUNCT
admet-2387	279	18	m.	m.	NOUN
admet-2387	279	19	reinisalo	reinisalo	PROPN
admet-2387	279	20	,	,	PUNCT
admet-2387	279	21	a.	a.	NOUN
admet-2387	279	22	valtari	valtari	PROPN
admet-2387	279	23	,	,	PUNCT
admet-2387	279	24	j.	j.	PROPN
admet-2387	279	25	puranen	puranen	PROPN
admet-2387	279	26	,	,	PUNCT
admet-2387	279	27	g.d.a	g.d.a	PROPN
admet-2387	279	28	.	.	PROPN
admet-2387	279	29	ricci	ricci	PROPN
admet-2387	279	30	,	,	PUNCT
admet-2387	279	31	e.m	e.m	PROPN
admet-2387	279	32	.	.	PROPN
admet-2387	279	33	heikkinen	heikkinen	PROPN
admet-2387	279	34	,	,	PUNCT
admet-2387	279	35	i.	i.	PROPN
admet-2387	279	36	gardner	gardner	PROPN
admet-2387	279	37	,	,	PUNCT
admet-2387	279	38	m.	m.	NOUN
admet-2387	279	39	ruponen	ruponen	PROPN
admet-2387	279	40	,	,	PUNCT
admet-2387	279	41	a.	a.	NOUN
admet-2387	279	42	urtti	urtti	PROPN
admet-2387	279	43	,	,	PUNCT
admet-2387	279	44	m.	m.	NOUN
admet-2387	279	45	jamei	jamei	PROPN
admet-2387	279	46	,	,	PUNCT
admet-2387	279	47	e.m	e.m	PROPN
admet-2387	279	48	.	.	PROPN
admet-2387	279	49	del	del	PROPN
admet-2387	279	50	amo	amo	PROPN
admet-2387	279	51	.	.	PROPN
admet-2387	279	52	ocular	ocular	ADJ
admet-2387	279	53	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	279	54	of	of	ADP
admet-2387	279	55	atenolol	atenolol	PROPN
admet-2387	279	56	,	,	PUNCT
admet-2387	279	57	timolol	timolol	NOUN
admet-2387	279	58	and	and	CCONJ
admet-2387	279	59	betaxolol	betaxolol	NOUN
admet-2387	279	60	cocktail	cocktail	NOUN
admet-2387	279	61	:	:	PUNCT
admet-2387	279	62	tissue	tissue	NOUN
admet-2387	279	63	exposures	exposure	NOUN
admet-2387	279	64	in	in	ADP
admet-2387	279	65	the	the	DET
admet-2387	279	66	rabbit	rabbit	NOUN
admet-2387	279	67	eye	eye	NOUN
admet-2387	279	68	.	.	PUNCT
admet-2387	280	1	european	european	PROPN
admet-2387	280	2	journal	journal	PROPN
admet-2387	280	3	of	of	ADP
admet-2387	280	4	pharmaceutics	pharmaceutic	NOUN
admet-2387	280	5	and	and	CCONJ
admet-2387	280	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2387	280	7	166	166	NUM
admet-2387	280	8	(	(	PUNCT
admet-2387	280	9	2021	2021	NUM
admet-2387	280	10	)	)	PUNCT
admet-2387	280	11	155	155	NUM
admet-2387	280	12	-	-	SYM
admet-2387	280	13	162	162	NUM
admet-2387	280	14	.	.	PUNCT
admet-2387	281	1	http://doi.org/10.1016/j.ejpb.2021.06.003	http://doi.org/10.1016/j.ejpb.2021.06.003	NUM
admet-2387	281	2	.	.	PUNCT
admet-2387	282	1	[	[	X
admet-2387	282	2	27	27	NUM
admet-2387	282	3	]	]	X
admet-2387	282	4	e.m	e.m	PROPN
admet-2387	282	5	.	.	PROPN
admet-2387	282	6	del	del	PROPN
admet-2387	282	7	amo	amo	PROPN
admet-2387	282	8	,	,	PUNCT
admet-2387	282	9	a.	a.	NOUN
admet-2387	282	10	hammid	hammid	PROPN
admet-2387	282	11	,	,	PUNCT
admet-2387	282	12	m.	m.	NOUN
admet-2387	282	13	tausch	tausch	PROPN
admet-2387	282	14	,	,	PUNCT
admet-2387	282	15	e.	e.	PROPN
admet-2387	282	16	toropainen	toropainen	PROPN
admet-2387	282	17	,	,	PUNCT
admet-2387	282	18	a.	a.	PROPN
admet-2387	282	19	sadeghi	sadeghi	PROPN
admet-2387	282	20	,	,	PUNCT
admet-2387	282	21	a.	a.	NOUN
admet-2387	282	22	valtari	valtari	PROPN
admet-2387	282	23	,	,	PUNCT
admet-2387	282	24	j.	j.	PROPN
admet-2387	282	25	puranen	puranen	PROPN
admet-2387	282	26	,	,	PUNCT
admet-2387	282	27	m.	m.	NOUN
admet-2387	282	28	reinisalo	reinisalo	PROPN
admet-2387	282	29	,	,	PUNCT
admet-2387	282	30	m.	m.	NOUN
admet-2387	282	31	ruponen	ruponen	PROPN
admet-2387	282	32	,	,	PUNCT
admet-2387	282	33	a.	a.	NOUN
admet-2387	282	34	urtti	urtti	PROPN
admet-2387	282	35	,	,	PUNCT
admet-2387	282	36	a.	a.	NOUN
admet-2387	282	37	sauer	sauer	PROPN
admet-2387	282	38	,	,	PUNCT
admet-2387	282	39	p.	p.	NOUN
admet-2387	282	40	honkakoski	honkakoski	NOUN
admet-2387	282	41	.	.	PUNCT
admet-2387	283	1	ocular	ocular	ADJ
admet-2387	283	2	metabolism	metabolism	NOUN
admet-2387	283	3	and	and	CCONJ
admet-2387	283	4	distribution	distribution	NOUN
admet-2387	283	5	of	of	ADP
admet-2387	283	6	drugs	drug	NOUN
admet-2387	283	7	in	in	ADP
admet-2387	283	8	the	the	DET
admet-2387	283	9	rabbit	rabbit	NOUN
admet-2387	283	10	eye	eye	NOUN
admet-2387	283	11	:	:	PUNCT
admet-2387	283	12	quantitative	quantitative	ADJ
admet-2387	283	13	assessment	assessment	NOUN
admet-2387	283	14	after	after	ADP
admet-2387	283	15	intracameral	intracameral	ADJ
admet-2387	283	16	and	and	CCONJ
admet-2387	283	17	intravitreal	intravitreal	ADJ
admet-2387	283	18	administrations	administration	NOUN
admet-2387	283	19	.	.	PUNCT
admet-2387	284	1	international	international	ADJ
admet-2387	284	2	journal	journal	PROPN
admet-2387	284	3	of	of	ADP
admet-2387	284	4	pharmaceutics	pharmaceutic	NOUN
admet-2387	284	5	613	613	NUM
admet-2387	284	6	(	(	PUNCT
admet-2387	284	7	2022	2022	NUM
admet-2387	284	8	)	)	PUNCT
admet-2387	284	9	121361	121361	NUM
admet-2387	284	10	.	.	PUNCT
admet-2387	285	1	http://doi.org/10.1016/j.ijpharm.2021.121361	http://doi.org/10.1016/j.ijpharm.2021.121361	NOUN
admet-2387	285	2	.	.	PUNCT
admet-2387	286	1	[	[	X
admet-2387	286	2	28	28	NUM
admet-2387	286	3	]	]	PUNCT
admet-2387	286	4	j.	j.	PROPN
admet-2387	286	5	zhang	zhang	PROPN
admet-2387	286	6	,	,	PUNCT
admet-2387	286	7	l.	l.	PROPN
admet-2387	286	8	wang	wang	PROPN
admet-2387	286	9	,	,	PUNCT
admet-2387	286	10	c.	c.	PROPN
admet-2387	286	11	gao	gao	PROPN
admet-2387	286	12	,	,	PUNCT
admet-2387	286	13	l.	l.	PROPN
admet-2387	286	14	zhang	zhang	PROPN
admet-2387	286	15	,	,	PUNCT
admet-2387	286	16	h.	h.	PROPN
admet-2387	286	17	xia	xia	PROPN
admet-2387	286	18	.	.	PUNCT
admet-2387	287	1	ocular	ocular	ADJ
admet-2387	287	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	287	3	of	of	ADP
admet-2387	287	4	topically	topically	ADV
admet-2387	287	5	-	-	PUNCT
admet-2387	287	6	applied	apply	VERB
admet-2387	287	7	ketoconazole	ketoconazole	NOUN
admet-2387	287	8	solution	solution	NOUN
admet-2387	287	9	containing	contain	VERB
admet-2387	287	10	hydroxypropyl	hydroxypropyl	NOUN
admet-2387	287	11	beta	beta	NOUN
admet-2387	287	12	-	-	PUNCT
admet-2387	287	13	cyclodextrin	cyclodextrin	NOUN
admet-2387	287	14	to	to	ADP
admet-2387	287	15	rabbits	rabbit	NOUN
admet-2387	287	16	.	.	PUNCT
admet-2387	288	1	journal	journal	NOUN
admet-2387	288	2	of	of	ADP
admet-2387	288	3	ocular	ocular	ADJ
admet-2387	288	4	pharmacology	pharmacology	NOUN
admet-2387	288	5	and	and	CCONJ
admet-2387	288	6	therapeutics	therapeutic	NOUN
admet-2387	288	7	24	24	NUM
admet-2387	288	8	(	(	PUNCT
admet-2387	288	9	2008	2008	NUM
admet-2387	288	10	)	)	PUNCT
admet-2387	288	11	501	501	NUM
admet-2387	288	12	-	-	PUNCT
admet-2387	288	13	506	506	NUM
admet-2387	288	14	.	.	PUNCT
admet-2387	289	1	http://doi.org/10.1089/jop.2008.0015	http://doi.org/10.1089/jop.2008.0015	PROPN
admet-2387	289	2	.	.	PUNCT
admet-2387	290	1	[	[	X
admet-2387	290	2	29	29	NUM
admet-2387	290	3	]	]	X
admet-2387	290	4	j.l	j.l	PROPN
admet-2387	290	5	.	.	PROPN
admet-2387	290	6	dumouchel	dumouchel	PROPN
admet-2387	290	7	,	,	PUNCT
admet-2387	290	8	n.	n.	PROPN
admet-2387	290	9	chemuturi	chemuturi	PROPN
admet-2387	290	10	,	,	PUNCT
admet-2387	290	11	m.n	m.n	PROPN
admet-2387	290	12	.	.	PROPN
admet-2387	290	13	milton	milton	PROPN
admet-2387	290	14	,	,	PUNCT
admet-2387	290	15	g.	g.	PROPN
admet-2387	290	16	camenisch	camenisch	PROPN
admet-2387	290	17	,	,	PUNCT
admet-2387	290	18	j.	j.	PROPN
admet-2387	290	19	chastain	chastain	PROPN
admet-2387	290	20	,	,	PUNCT
admet-2387	290	21	m.	m.	NOUN
admet-2387	290	22	walles	walle	NOUN
admet-2387	290	23	,	,	PUNCT
admet-2387	290	24	v.	v.	PROPN
admet-2387	290	25	sasseville	sasseville	PROPN
admet-2387	290	26	,	,	PUNCT
admet-2387	290	27	m.	m.	NOUN
admet-2387	290	28	gunduz	gunduz	PROPN
admet-2387	290	29	,	,	PUNCT
admet-2387	290	30	g.r	g.r	PROPN
admet-2387	290	31	.	.	PROPN
admet-2387	290	32	iyer	iyer	PROPN
admet-2387	290	33	,	,	PUNCT
admet-2387	290	34	u.a	u.a	PROPN
admet-2387	290	35	.	.	PROPN
admet-2387	290	36	argikar	argikar	PROPN
admet-2387	290	37	.	.	PUNCT
admet-2387	291	1	models	model	NOUN
admet-2387	291	2	and	and	CCONJ
admet-2387	291	3	approaches	approach	NOUN
admet-2387	291	4	describing	describe	VERB
admet-2387	291	5	the	the	DET
admet-2387	291	6	metabolism	metabolism	NOUN
admet-2387	291	7	,	,	PUNCT
admet-2387	291	8	transport	transport	NOUN
admet-2387	291	9	,	,	PUNCT
admet-2387	291	10	and	and	CCONJ
admet-2387	291	11	toxicity	toxicity	NOUN
admet-2387	291	12	of	of	ADP
admet-2387	291	13	drugs	drug	NOUN
admet-2387	291	14	administered	administer	VERB
admet-2387	291	15	by	by	ADP
admet-2387	291	16	the	the	DET
admet-2387	291	17	ocular	ocular	ADJ
admet-2387	291	18	route	route	NOUN
admet-2387	291	19	.	.	PUNCT
admet-2387	292	1	drug	drug	NOUN
admet-2387	292	2	metabolism	metabolism	NOUN
admet-2387	292	3	and	and	CCONJ
admet-2387	292	4	disposition	disposition	NOUN
admet-2387	292	5	46	46	NUM
admet-2387	292	6	(	(	PUNCT
admet-2387	292	7	2018	2018	NUM
admet-2387	292	8	)	)	PUNCT
admet-2387	292	9	1670	1670	NUM
admet-2387	292	10	-	-	SYM
admet-2387	292	11	1683	1683	NUM
admet-2387	292	12	.	.	PUNCT
admet-2387	293	1	http://doi.org/10.1124/dmd.118.082974	http://doi.org/10.1124/dmd.118.082974	NOUN
admet-2387	293	2	.	.	PUNCT
admet-2387	294	1	[	[	X
admet-2387	294	2	30	30	NUM
admet-2387	294	3	]	]	X
admet-2387	294	4	r.j	r.j	PROPN
admet-2387	294	5	.	.	PROPN
admet-2387	294	6	rodriguez	rodriguez	PROPN
admet-2387	294	7	,	,	PUNCT
admet-2387	294	8	d.j	d.j	PROPN
admet-2387	294	9	.	.	PROPN
admet-2387	294	10	acosta	acosta	PROPN
admet-2387	294	11	.	.	PUNCT
admet-2387	295	1	metabolism	metabolism	NOUN
admet-2387	295	2	of	of	ADP
admet-2387	295	3	ketoconazole	ketoconazole	NOUN
admet-2387	295	4	and	and	CCONJ
admet-2387	295	5	deacetylated	deacetylate	VERB
admet-2387	295	6	ketoconazole	ketoconazole	NOUN
admet-2387	295	7	by	by	ADP
admet-2387	295	8	rat	rat	NOUN
admet-2387	295	9	hepatic	hepatic	ADJ
admet-2387	295	10	microsomes	microsome	NOUN
admet-2387	295	11	and	and	CCONJ
admet-2387	295	12	flavin	flavin	NOUN
admet-2387	295	13	-	-	PUNCT
admet-2387	295	14	containing	contain	VERB
admet-2387	295	15	monooxygenases	monooxygenase	NOUN
admet-2387	295	16	.	.	PUNCT
admet-2387	296	1	drug	drug	NOUN
admet-2387	296	2	metabolism	metabolism	NOUN
admet-2387	296	3	and	and	CCONJ
admet-2387	296	4	disposition	disposition	NOUN
admet-2387	296	5	25	25	NUM
admet-2387	296	6	(	(	PUNCT
admet-2387	296	7	1997	1997	NUM
admet-2387	296	8	)	)	PUNCT
admet-2387	296	9	772	772	NUM
admet-2387	296	10	-	-	SYM
admet-2387	296	11	777	777	NUM
admet-2387	296	12	.	.	PUNCT
admet-2387	297	1	https://pubmed.ncbi.nlm.nih.gov/9193882/.	https://pubmed.ncbi.nlm.nih.gov/9193882/.	AUX
admet-2387	297	2	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	297	3	http://doi.org/10.1002/cpdd.100	http://doi.org/10.1002/cpdd.100	NOUN
admet-2387	297	4	https://doi.org/10.1093/cid/cit548	https://doi.org/10.1093/cid/cit548	PROPN
admet-2387	297	5	http://doi.org/10.1136/bmj.294.6569.419	http://doi.org/10.1136/bmj.294.6569.419	PROPN
admet-2387	297	6	https://doi.org/10.1002/jcph.795	https://doi.org/10.1002/jcph.795	ADV
admet-2387	297	7	http://doi.org/10.1136/bmj.290.6464.260	http://doi.org/10.1136/bmj.290.6464.260	PROPN
admet-2387	297	8	http://doi.org/10.1016/j.addr.2006.07.027	http://doi.org/10.1016/j.addr.2006.07.027	PROPN
admet-2387	297	9	http://doi.org/10.1007/s13346-016-0339-2	http://doi.org/10.1007/s13346-016-0339-2	PROPN
admet-2387	297	10	http://doi.org/10.1007/164_2016_32	http://doi.org/10.1007/164_2016_32	PROPN
admet-2387	297	11	https://doi.org/10.1517/17425247.3.2.275	https://doi.org/10.1517/17425247.3.2.275	PROPN
admet-2387	297	12	http://doi.org/10.1002/prp2.545	http://doi.org/10.1002/prp2.545	PROPN
admet-2387	297	13	http://doi.org/10.1021/acs.molpharmaceut.9b01024	http://doi.org/10.1021/acs.molpharmaceut.9b01024	NUM
admet-2387	297	14	http://doi.org/10.1016/j.ejpb.2021.06.003	http://doi.org/10.1016/j.ejpb.2021.06.003	NUM
admet-2387	297	15	http://doi.org/10.1016/j.ijpharm.2021.121361	http://doi.org/10.1016/j.ijpharm.2021.121361	NOUN
admet-2387	297	16	http://doi.org/10.1089/jop.2008.0015	http://doi.org/10.1089/jop.2008.0015	VERB
admet-2387	298	1	http://doi.org/10.1124/dmd.118.082974	http://doi.org/10.1124/dmd.118.082974	PROPN
admet-2387	298	2	j.	j.	PROPN
admet-2387	298	3	pu	pu	PROPN
admet-2387	298	4	et	et	PROPN
admet-2387	298	5	al	al	PROPN
admet-2387	298	6	.	.	PROPN
admet-2387	298	7	admet	admet	PROPN
admet-2387	298	8	&	&	CCONJ
admet-2387	298	9	dmpk	dmpk	PROPN
admet-2387	298	10	12(6	12(6	NUM
admet-2387	298	11	)	)	PUNCT
admet-2387	298	12	(	(	PUNCT
admet-2387	298	13	2024	2024	NUM
admet-2387	298	14	)	)	PUNCT
admet-2387	298	15	943	943	NUM
admet-2387	298	16	-	-	SYM
admet-2387	298	17	955	955	NUM
admet-2387	298	18	954	954	NUM
admet-2387	299	1	[	[	X
admet-2387	299	2	31	31	NUM
admet-2387	299	3	]	]	X
admet-2387	299	4	d.a	d.a	PROPN
admet-2387	299	5	.	.	PROPN
admet-2387	299	6	hamdy	hamdy	PROPN
admet-2387	299	7	,	,	PUNCT
admet-2387	299	8	d.r	d.r	PROPN
admet-2387	299	9	.	.	PROPN
admet-2387	299	10	brocks	brock	NOUN
admet-2387	299	11	.	.	PUNCT
admet-2387	300	1	nonlinear	nonlinear	ADJ
admet-2387	300	2	stereoselective	stereoselective	ADJ
admet-2387	300	3	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	300	4	of	of	ADP
admet-2387	300	5	ketoconazole	ketoconazole	NOUN
admet-2387	300	6	in	in	ADP
admet-2387	300	7	rat	rat	NOUN
admet-2387	300	8	after	after	ADP
admet-2387	300	9	administration	administration	NOUN
admet-2387	300	10	of	of	ADP
admet-2387	300	11	racemate	racemate	PROPN
admet-2387	300	12	.	.	PUNCT
admet-2387	301	1	chirality	chirality	NOUN
admet-2387	301	2	21	21	NUM
admet-2387	301	3	(	(	PUNCT
admet-2387	301	4	2009	2009	NUM
admet-2387	301	5	)	)	PUNCT
admet-2387	301	6	704	704	NUM
admet-2387	301	7	-	-	SYM
admet-2387	301	8	712	712	NUM
admet-2387	301	9	.	.	PUNCT
admet-2387	301	10	http://doi.org/10.1002/chir.20669	http://doi.org/10.1002/chir.20669	NOUN
admet-2387	301	11	.	.	PUNCT
admet-2387	302	1	[	[	X
admet-2387	302	2	32	32	NUM
admet-2387	302	3	]	]	X
admet-2387	302	4	r.p	r.p	PROPN
admet-2387	302	5	.	.	PROPN
admet-2387	302	6	remmel	remmel	PROPN
admet-2387	302	7	,	,	PUNCT
admet-2387	302	8	k.	k.	PROPN
admet-2387	302	9	amoh	amoh	PROPN
admet-2387	302	10	,	,	PUNCT
admet-2387	302	11	m.m	m.m	PROPN
admet-2387	302	12	.	.	PROPN
admet-2387	302	13	abdel	abdel	PROPN
admet-2387	302	14	-	-	PUNCT
admet-2387	302	15	monem	monem	PROPN
admet-2387	302	16	.	.	PUNCT
admet-2387	303	1	the	the	DET
admet-2387	303	2	disposition	disposition	NOUN
admet-2387	303	3	and	and	CCONJ
admet-2387	303	4	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	303	5	of	of	ADP
admet-2387	303	6	ketoconazole	ketoconazole	NOUN
admet-2387	303	7	in	in	ADP
admet-2387	303	8	the	the	DET
admet-2387	303	9	rat	rat	PROPN
admet-2387	303	10	.	.	PROPN
admet-2387	303	11	drug	drug	NOUN
admet-2387	303	12	metabolism	metabolism	NOUN
admet-2387	303	13	and	and	CCONJ
admet-2387	303	14	disposition	disposition	NOUN
admet-2387	303	15	15	15	NUM
admet-2387	303	16	(	(	PUNCT
admet-2387	303	17	1987	1987	NUM
admet-2387	303	18	)	)	PUNCT
admet-2387	303	19	735	735	NUM
admet-2387	303	20	-	-	SYM
admet-2387	303	21	739	739	NUM
admet-2387	303	22	.	.	PUNCT
admet-2387	303	23	https://pubmed.ncbi.nlm.nih.gov/2893696/.	https://pubmed.ncbi.nlm.nih.gov/2893696/.	PUNCT
admet-2387	304	1	[	[	X
admet-2387	304	2	33	33	NUM
admet-2387	304	3	]	]	X
admet-2387	304	4	d.a	d.a	PROPN
admet-2387	304	5	.	.	PROPN
admet-2387	304	6	hamdy	hamdy	PROPN
admet-2387	304	7	,	,	PUNCT
admet-2387	304	8	d.r	d.r	PROPN
admet-2387	304	9	.	.	PROPN
admet-2387	304	10	brocks	brock	NOUN
admet-2387	304	11	.	.	PUNCT
admet-2387	305	1	the	the	DET
admet-2387	305	2	effect	effect	NOUN
admet-2387	305	3	of	of	ADP
admet-2387	305	4	increased	increase	VERB
admet-2387	305	5	lipoprotein	lipoprotein	ADJ
admet-2387	305	6	levels	level	NOUN
admet-2387	305	7	on	on	ADP
admet-2387	305	8	the	the	DET
admet-2387	305	9	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	305	10	of	of	ADP
admet-2387	305	11	ketoconazole	ketoconazole	NOUN
admet-2387	305	12	enantiomers	enantiomer	NOUN
admet-2387	305	13	in	in	ADP
admet-2387	305	14	the	the	DET
admet-2387	305	15	rat	rat	NOUN
admet-2387	305	16	.	.	PUNCT
admet-2387	306	1	xenobiotica	xenobiotica	PROPN
admet-2387	306	2	41	41	NUM
admet-2387	306	3	(	(	PUNCT
admet-2387	306	4	2011	2011	NUM
admet-2387	306	5	)	)	PUNCT
admet-2387	306	6	137	137	NUM
admet-2387	306	7	-	-	SYM
admet-2387	306	8	143	143	NUM
admet-2387	306	9	.	.	PUNCT
admet-2387	307	1	http://doi.org/10.3109/00498254.2010.529178	http://doi.org/10.3109/00498254.2010.529178	NOUN
admet-2387	307	2	.	.	PUNCT
admet-2387	308	1	[	[	X
admet-2387	308	2	34	34	NUM
admet-2387	308	3	]	]	X
admet-2387	308	4	l.l	l.l	PROPN
admet-2387	308	5	.	.	PROPN
admet-2387	308	6	von	von	PROPN
admet-2387	308	7	moltke	moltke	PROPN
admet-2387	308	8	,	,	PUNCT
admet-2387	308	9	d.j	d.j	PROPN
admet-2387	308	10	.	.	PROPN
admet-2387	308	11	greenblatt	greenblatt	PROPN
admet-2387	308	12	,	,	PUNCT
admet-2387	308	13	m.m	m.m	PROPN
admet-2387	308	14	.	.	PROPN
admet-2387	308	15	cotreau	cotreau	PROPN
admet-2387	308	16	-	-	PUNCT
admet-2387	308	17	bibbo	bibbo	PROPN
admet-2387	308	18	,	,	PUNCT
admet-2387	308	19	su	su	PROPN
admet-2387	308	20	xiang	xiang	PROPN
admet-2387	308	21	duan	duan	PROPN
admet-2387	308	22	,	,	PUNCT
admet-2387	308	23	j.s	j.s	PROPN
admet-2387	308	24	.	.	PROPN
admet-2387	308	25	harmatz	harmatz	PROPN
admet-2387	308	26	,	,	PUNCT
admet-2387	308	27	r.i	r.i	PROPN
admet-2387	308	28	.	.	PROPN
admet-2387	308	29	shader	shader	PROPN
admet-2387	308	30	.	.	PUNCT
admet-2387	309	1	inhibition	inhibition	NOUN
admet-2387	309	2	of	of	ADP
admet-2387	309	3	desipramine	desipramine	NOUN
admet-2387	309	4	hydroxylation	hydroxylation	NOUN
admet-2387	309	5	in	in	ADP
admet-2387	309	6	vitro	vitro	X
admet-2387	309	7	by	by	ADP
admet-2387	309	8	serotonin	serotonin	NOUN
admet-2387	309	9	-	-	PUNCT
admet-2387	309	10	reuptakeinhibitor	reuptakeinhibitor	NOUN
admet-2387	309	11	antidepressants	antidepressant	NOUN
admet-2387	309	12	,	,	PUNCT
admet-2387	309	13	and	and	CCONJ
admet-2387	309	14	by	by	ADP
admet-2387	309	15	quinidine	quinidine	NOUN
admet-2387	309	16	and	and	CCONJ
admet-2387	309	17	ketoconazole	ketoconazole	NOUN
admet-2387	309	18	:	:	PUNCT
admet-2387	309	19	a	a	DET
admet-2387	309	20	model	model	NOUN
admet-2387	309	21	system	system	NOUN
admet-2387	309	22	to	to	PART
admet-2387	309	23	predict	predict	VERB
admet-2387	309	24	drug	drug	NOUN
admet-2387	309	25	interactions	interaction	NOUN
admet-2387	309	26	in	in	ADP
admet-2387	309	27	vivo	vivo	NOUN
admet-2387	309	28	.	.	PUNCT
admet-2387	310	1	journal	journal	PROPN
admet-2387	310	2	of	of	ADP
admet-2387	310	3	pharmacology	pharmacology	NOUN
admet-2387	310	4	and	and	CCONJ
admet-2387	310	5	experimental	experimental	ADJ
admet-2387	310	6	therapeutics	therapeutic	NOUN
admet-2387	310	7	268	268	NUM
admet-2387	310	8	(	(	PUNCT
admet-2387	310	9	1994	1994	NUM
admet-2387	310	10	)	)	PUNCT
admet-2387	310	11	1278	1278	NUM
admet-2387	310	12	-	-	SYM
admet-2387	310	13	1283	1283	NUM
admet-2387	310	14	.	.	PUNCT
admet-2387	311	1	https://pubmed.ncbi.nlm.nih.gov/8138941/.	https://pubmed.ncbi.nlm.nih.gov/8138941/.	PROPN
admet-2387	312	1	[	[	X
admet-2387	312	2	35	35	NUM
admet-2387	312	3	]	]	X
admet-2387	312	4	l.	l.	PROPN
admet-2387	312	5	von	von	PROPN
admet-2387	312	6	moltke	moltke	PROPN
admet-2387	312	7	,	,	PUNCT
admet-2387	312	8	d.	d.	PROPN
admet-2387	312	9	greenblatt	greenblatt	PROPN
admet-2387	312	10	,	,	PUNCT
admet-2387	312	11	m.	m.	PROPN
admet-2387	312	12	cotreau‐bibbo	cotreau‐bibbo	PROPN
admet-2387	312	13	,	,	PUNCT
admet-2387	312	14	j.	j.	PROPN
admet-2387	312	15	harmatz	harmatz	PROPN
admet-2387	312	16	,	,	PUNCT
admet-2387	312	17	r.	r.	PROPN
admet-2387	312	18	shader	shader	PROPN
admet-2387	312	19	.	.	PUNCT
admet-2387	313	1	inhibitors	inhibitor	NOUN
admet-2387	313	2	of	of	ADP
admet-2387	313	3	alprazolam	alprazolam	PROPN
admet-2387	313	4	metabolism	metabolism	NOUN
admet-2387	313	5	in	in	ADP
admet-2387	313	6	vitro	vitro	NOUN
admet-2387	313	7	:	:	PUNCT
admet-2387	313	8	effect	effect	NOUN
admet-2387	313	9	of	of	ADP
admet-2387	313	10	serotonin‐	serotonin‐	NOUN
admet-2387	313	11	reuptake‐inhibitor	reuptake‐inhibitor	NOUN
admet-2387	313	12	antidepressants	antidepressant	NOUN
admet-2387	313	13	,	,	PUNCT
admet-2387	313	14	ketoconazole	ketoconazole	NOUN
admet-2387	313	15	and	and	CCONJ
admet-2387	313	16	quinidine	quinidine	NOUN
admet-2387	313	17	.	.	PUNCT
admet-2387	314	1	british	british	ADJ
admet-2387	314	2	journal	journal	PROPN
admet-2387	314	3	of	of	ADP
admet-2387	314	4	clinical	clinical	ADJ
admet-2387	314	5	pharmacology	pharmacology	NOUN
admet-2387	314	6	38	38	NUM
admet-2387	314	7	(	(	PUNCT
admet-2387	314	8	1994	1994	NUM
admet-2387	314	9	)	)	PUNCT
admet-2387	314	10	23	23	NUM
admet-2387	314	11	-	-	SYM
admet-2387	314	12	31	31	NUM
admet-2387	314	13	.	.	PUNCT
admet-2387	315	1	http://doi.org/10.1111/j.13652125.1994.tb04317.x	http://doi.org/10.1111/j.13652125.1994.tb04317.x	X
admet-2387	315	2	.	.	PUNCT
admet-2387	316	1	[	[	X
admet-2387	316	2	36	36	NUM
admet-2387	316	3	]	]	X
admet-2387	316	4	m.d	m.d	PROPN
admet-2387	316	5	.	.	PROPN
admet-2387	316	6	linas	linas	PROPN
admet-2387	316	7	,	,	PUNCT
admet-2387	316	8	f.	f.	PROPN
admet-2387	316	9	malecaze	malecaze	PROPN
admet-2387	316	10	,	,	PUNCT
admet-2387	316	11	m.h	m.h	PROPN
admet-2387	316	12	.	.	PROPN
admet-2387	316	13	bessieres	bessieres	PROPN
admet-2387	316	14	,	,	PUNCT
admet-2387	316	15	m.n	m.n	PROPN
admet-2387	316	16	.	.	PROPN
admet-2387	316	17	jaureguy	jaureguy	PROPN
admet-2387	316	18	,	,	PUNCT
admet-2387	316	19	a.	a.	NOUN
admet-2387	316	20	mathis	mathis	PROPN
admet-2387	316	21	,	,	PUNCT
admet-2387	316	22	p.	p.	PROPN
admet-2387	316	23	bec	bec	PROPN
admet-2387	316	24	,	,	PUNCT
admet-2387	316	25	j.p	j.p	PROPN
admet-2387	316	26	.	.	PROPN
admet-2387	316	27	seguela	seguela	PROPN
admet-2387	316	28	,	,	PUNCT
admet-2387	316	29	d’a	d’a	PROPN
admet-2387	316	30	a.	a.	NOUN
admet-2387	316	31	monbrun	monbrun	PROPN
admet-2387	316	32	.	.	PUNCT
admet-2387	317	1	etude	etude	NOUN
admet-2387	317	2	expérimentale	expérimentale	NOUN
admet-2387	317	3	de	de	PROPN
admet-2387	317	4	la	la	PROPN
admet-2387	317	5	diffusion	diffusion	NOUN
admet-2387	317	6	intra	intra	ADJ
admet-2387	317	7	-	-	ADJ
admet-2387	317	8	oculaire	oculaire	ADJ
admet-2387	317	9	du	du	PROPN
admet-2387	317	10	kétoconazole	kétoconazole	PROPN
admet-2387	317	11	chez	chez	PROPN
admet-2387	317	12	le	le	X
admet-2387	317	13	lapin	lapin	PROPN
admet-2387	317	14	.	.	PUNCT
admet-2387	318	1	medecine	medecine	PROPN
admet-2387	318	2	et	et	PROPN
admet-2387	318	3	maladies	maladie	VERB
admet-2387	318	4	infectieuses	infectieuse	NOUN
admet-2387	318	5	15	15	NUM
admet-2387	318	6	(	(	PUNCT
admet-2387	318	7	1985	1985	NUM
admet-2387	318	8	)	)	PUNCT
admet-2387	318	9	389	389	NUM
admet-2387	318	10	-	-	SYM
admet-2387	318	11	390	390	NUM
admet-2387	318	12	.	.	PUNCT
admet-2387	319	1	http://doi.org/10.1016/s0399077x(85)80039-1	http://doi.org/10.1016/s0399077x(85)80039-1	NOUN
admet-2387	319	2	.	.	PUNCT
admet-2387	320	1	[	[	X
admet-2387	320	2	37	37	NUM
admet-2387	320	3	]	]	SYM
admet-2387	320	4	d.b	d.b	PROPN
admet-2387	320	5	.	.	PROPN
admet-2387	320	6	haughey	haughey	PROPN
admet-2387	320	7	,	,	PUNCT
admet-2387	320	8	w.j	w.j	PROPN
admet-2387	320	9	.	.	PROPN
admet-2387	320	10	jusko	jusko	PROPN
admet-2387	320	11	.	.	PUNCT
admet-2387	321	1	effect	effect	NOUN
admet-2387	321	2	of	of	ADP
admet-2387	321	3	ketoconazole	ketoconazole	NOUN
admet-2387	321	4	on	on	ADP
admet-2387	321	5	methylprednisolone	methylprednisolone	ADJ
admet-2387	321	6	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	321	7	and	and	CCONJ
admet-2387	321	8	receptor	receptor	NOUN
admet-2387	321	9	/	/	SYM
admet-2387	321	10	gene	gene	NOUN
admet-2387	321	11	-	-	PUNCT
admet-2387	321	12	mediated	mediate	VERB
admet-2387	321	13	pharmacodynamics	pharmacodynamic	NOUN
admet-2387	321	14	.	.	PUNCT
admet-2387	322	1	journal	journal	PROPN
admet-2387	322	2	of	of	ADP
admet-2387	322	3	pharmacology	pharmacology	NOUN
admet-2387	322	4	and	and	CCONJ
admet-2387	322	5	experimental	experimental	ADJ
admet-2387	322	6	therapeutics	therapeutic	NOUN
admet-2387	322	7	259	259	NUM
admet-2387	322	8	(	(	PUNCT
admet-2387	322	9	1991	1991	NUM
admet-2387	322	10	)	)	PUNCT
admet-2387	322	11	826	826	NUM
admet-2387	322	12	-	-	SYM
admet-2387	322	13	832	832	NUM
admet-2387	322	14	.	.	PUNCT
admet-2387	323	1	https://pubmed.ncbi.nlm.nih.gov/1941630/.	https://pubmed.ncbi.nlm.nih.gov/1941630/.	X
admet-2387	323	2	[	[	X
admet-2387	323	3	38	38	NUM
admet-2387	323	4	]	]	X
admet-2387	323	5	h.l	h.l	PROPN
admet-2387	323	6	.	.	PROPN
admet-2387	323	7	bomont	bomont	PROPN
admet-2387	323	8	,	,	PUNCT
admet-2387	323	9	m.h	m.h	PROPN
admet-2387	323	10	.	.	PROPN
admet-2387	323	11	tarbit	tarbit	PROPN
admet-2387	323	12	,	,	PUNCT
admet-2387	323	13	m.j	m.j	PROPN
admet-2387	323	14	.	.	PROPN
admet-2387	323	15	humphrey	humphrey	PROPN
admet-2387	323	16	,	,	PUNCT
admet-2387	323	17	j.b	j.b	PROPN
admet-2387	323	18	.	.	PROPN
admet-2387	323	19	houston	houston	PROPN
admet-2387	323	20	.	.	PUNCT
admet-2387	324	1	disposition	disposition	NOUN
admet-2387	324	2	of	of	ADP
admet-2387	324	3	azole	azole	ADJ
admet-2387	324	4	antifungal	antifungal	ADJ
admet-2387	324	5	agents	agent	NOUN
admet-2387	324	6	.	.	PUNCT
admet-2387	325	1	ii	ii	PROPN
admet-2387	325	2	.	.	PUNCT
admet-2387	325	3	hepatic	hepatic	ADJ
admet-2387	325	4	binding	binding	NOUN
admet-2387	325	5	and	and	CCONJ
admet-2387	325	6	clearance	clearance	NOUN
admet-2387	325	7	of	of	ADP
admet-2387	325	8	dichlorophenyl	dichlorophenyl	NOUN
admet-2387	325	9	-	-	PUNCT
admet-2387	325	10	bis	bis	NOUN
admet-2387	325	11	-	-	NOUN
admet-2387	325	12	triazolylpropanol	triazolylpropanol	NOUN
admet-2387	325	13	(	(	PUNCT
admet-2387	325	14	dtp	dtp	PROPN
admet-2387	325	15	)	)	PUNCT
admet-2387	325	16	in	in	ADP
admet-2387	325	17	the	the	DET
admet-2387	325	18	rat	rat	NOUN
admet-2387	325	19	.	.	PROPN
admet-2387	325	20	pharmaceutical	pharmaceutical	ADJ
admet-2387	325	21	research	research	NOUN
admet-2387	325	22	:	:	PUNCT
admet-2387	325	23	an	an	DET
admet-2387	325	24	official	official	ADJ
admet-2387	325	25	journal	journal	NOUN
admet-2387	325	26	of	of	ADP
admet-2387	325	27	the	the	DET
admet-2387	325	28	american	american	PROPN
admet-2387	325	29	association	association	PROPN
admet-2387	325	30	of	of	ADP
admet-2387	325	31	pharmaceutical	pharmaceutical	ADJ
admet-2387	325	32	scientists	scientist	NOUN
admet-2387	325	33	11	11	NUM
admet-2387	325	34	(	(	PUNCT
admet-2387	325	35	1994	1994	NUM
admet-2387	325	36	)	)	PUNCT
admet-2387	325	37	951	951	NUM
admet-2387	325	38	-	-	SYM
admet-2387	325	39	960	960	NUM
admet-2387	325	40	.	.	PUNCT
admet-2387	326	1	http://doi.org/10.1023/a:1018966800208	http://doi.org/10.1023/a:1018966800208	ADJ
admet-2387	326	2	.	.	PUNCT
admet-2387	327	1	[	[	X
admet-2387	327	2	39	39	NUM
admet-2387	327	3	]	]	X
admet-2387	327	4	a.s	a.s	PROPN
admet-2387	327	5	.	.	PROPN
admet-2387	327	6	kalgutkar	kalgutkar	PROPN
admet-2387	327	7	,	,	PUNCT
admet-2387	327	8	b.c	b.c	PROPN
admet-2387	327	9	.	.	PROPN
admet-2387	327	10	crews	crew	NOUN
admet-2387	327	11	,	,	PUNCT
admet-2387	327	12	s.w	s.w	PROPN
admet-2387	327	13	.	.	PROPN
admet-2387	327	14	rowlinson	rowlinson	PROPN
admet-2387	327	15	,	,	PUNCT
admet-2387	327	16	a.b	a.b	PROPN
admet-2387	327	17	.	.	PROPN
admet-2387	327	18	marnett	marnett	PROPN
admet-2387	327	19	,	,	PUNCT
admet-2387	327	20	k.r	k.r	PROPN
admet-2387	327	21	.	.	PROPN
admet-2387	327	22	kozak	kozak	PROPN
admet-2387	327	23	,	,	PUNCT
admet-2387	327	24	r.p	r.p	PROPN
admet-2387	327	25	.	.	PROPN
admet-2387	327	26	remmel	remmel	PROPN
admet-2387	327	27	,	,	PUNCT
admet-2387	327	28	l.j	l.j	PROPN
admet-2387	327	29	.	.	PROPN
admet-2387	327	30	marnett	marnett	PROPN
admet-2387	327	31	.	.	PUNCT
admet-2387	327	32	biochemically	biochemically	ADV
admet-2387	327	33	based	base	VERB
admet-2387	327	34	design	design	NOUN
admet-2387	327	35	of	of	ADP
admet-2387	327	36	cyclooxygenase-2	cyclooxygenase-2	NUM
admet-2387	327	37	(	(	PUNCT
admet-2387	327	38	cox-2	cox-2	NOUN
admet-2387	327	39	)	)	PUNCT
admet-2387	327	40	inhibitors	inhibitor	NOUN
admet-2387	327	41	:	:	PUNCT
admet-2387	327	42	facile	facile	ADJ
admet-2387	327	43	conversion	conversion	NOUN
admet-2387	327	44	of	of	ADP
admet-2387	327	45	nonsteroidal	nonsteroidal	NOUN
admet-2387	327	46	antiinflammatory	antiinflammatory	NOUN
admet-2387	327	47	drugs	drug	NOUN
admet-2387	327	48	to	to	PART
admet-2387	327	49	potent	potent	VERB
admet-2387	327	50	and	and	CCONJ
admet-2387	327	51	highly	highly	ADV
admet-2387	327	52	selective	selective	ADJ
admet-2387	327	53	cox-2	cox-2	ADJ
admet-2387	327	54	inhibitors	inhibitor	NOUN
admet-2387	327	55	.	.	PUNCT
admet-2387	328	1	proceedings	proceeding	NOUN
admet-2387	328	2	of	of	ADP
admet-2387	328	3	the	the	DET
admet-2387	328	4	national	national	PROPN
admet-2387	328	5	academy	academy	PROPN
admet-2387	328	6	of	of	ADP
admet-2387	328	7	sciences	sciences	PROPN
admet-2387	328	8	of	of	ADP
admet-2387	328	9	the	the	DET
admet-2387	328	10	united	united	PROPN
admet-2387	328	11	states	states	PROPN
admet-2387	328	12	of	of	ADP
admet-2387	328	13	america	america	PROPN
admet-2387	328	14	97	97	NUM
admet-2387	328	15	(	(	PUNCT
admet-2387	328	16	2000	2000	NUM
admet-2387	328	17	)	)	PUNCT
admet-2387	328	18	925	925	NUM
admet-2387	328	19	-	-	SYM
admet-2387	328	20	930	930	NUM
admet-2387	328	21	.	.	PUNCT
admet-2387	329	1	http://doi.org/10.1073/pnas.97.2.925	http://doi.org/10.1073/pnas.97.2.925	ADJ
admet-2387	329	2	.	.	PUNCT
admet-2387	330	1	[	[	X
admet-2387	330	2	40	40	NUM
admet-2387	330	3	]	]	X
admet-2387	330	4	r.w	r.w	PROPN
admet-2387	330	5	.	.	PROPN
admet-2387	330	6	klecker	klecker	PROPN
admet-2387	330	7	,	,	PUNCT
admet-2387	330	8	c.a	c.a	PROPN
admet-2387	330	9	.	.	PROPN
admet-2387	330	10	jamis	jamis	PROPN
admet-2387	330	11	-	-	PUNCT
admet-2387	330	12	dow	dow	PROPN
admet-2387	330	13	,	,	PUNCT
admet-2387	330	14	m.j	m.j	PROPN
admet-2387	330	15	.	.	PROPN
admet-2387	330	16	egorin	egorin	PROPN
admet-2387	330	17	,	,	PUNCT
admet-2387	330	18	k.	k.	PROPN
admet-2387	330	19	erkmen	erkmen	PROPN
admet-2387	330	20	,	,	PUNCT
admet-2387	330	21	r.j	r.j	PROPN
admet-2387	330	22	.	.	PROPN
admet-2387	330	23	parker	parker	PROPN
admet-2387	330	24	,	,	PUNCT
admet-2387	330	25	r.	r.	PROPN
admet-2387	330	26	stevens	stevens	PROPN
admet-2387	330	27	,	,	PUNCT
admet-2387	330	28	j.m	j.m	PROPN
admet-2387	330	29	.	.	PROPN
admet-2387	330	30	collins	collins	PROPN
admet-2387	330	31	.	.	PUNCT
admet-2387	331	1	effect	effect	NOUN
admet-2387	331	2	of	of	ADP
admet-2387	331	3	cimetidine	cimetidine	NOUN
admet-2387	331	4	,	,	PUNCT
admet-2387	331	5	probenecid	probenecid	PROPN
admet-2387	331	6	,	,	PUNCT
admet-2387	331	7	and	and	CCONJ
admet-2387	331	8	ketoconazole	ketoconazole	NOUN
admet-2387	331	9	on	on	ADP
admet-2387	331	10	the	the	DET
admet-2387	331	11	distribution	distribution	NOUN
admet-2387	331	12	,	,	PUNCT
admet-2387	331	13	biliary	biliary	NOUN
admet-2387	331	14	secretion	secretion	NOUN
admet-2387	331	15	,	,	PUNCT
admet-2387	331	16	and	and	CCONJ
admet-2387	331	17	metabolism	metabolism	NOUN
admet-2387	331	18	of	of	ADP
admet-2387	331	19	[	[	X
admet-2387	331	20	3h]taxol	3h]taxol	NOUN
admet-2387	331	21	in	in	ADP
admet-2387	331	22	the	the	DET
admet-2387	331	23	sprague	sprague	NOUN
admet-2387	331	24	-	-	PUNCT
admet-2387	331	25	dawley	dawley	NOUN
admet-2387	331	26	rat	rat	NOUN
admet-2387	331	27	.	.	PROPN
admet-2387	331	28	drug	drug	NOUN
admet-2387	331	29	metabolism	metabolism	NOUN
admet-2387	331	30	and	and	CCONJ
admet-2387	331	31	disposition	disposition	NOUN
admet-2387	331	32	22	22	NUM
admet-2387	331	33	(	(	PUNCT
admet-2387	331	34	1994	1994	NUM
admet-2387	331	35	)	)	PUNCT
admet-2387	331	36	254	254	NUM
admet-2387	331	37	-	-	SYM
admet-2387	331	38	258	258	NUM
admet-2387	331	39	.	.	PUNCT
admet-2387	332	1	https://pubmed.ncbi.nlm.nih.gov/7912177/.	https://pubmed.ncbi.nlm.nih.gov/7912177/.	X
admet-2387	333	1	[	[	X
admet-2387	333	2	41	41	NUM
admet-2387	333	3	]	]	PUNCT
admet-2387	333	4	k.	k.	PROPN
admet-2387	333	5	igarashi	igarashi	PROPN
admet-2387	333	6	,	,	PUNCT
admet-2387	333	7	f.	f.	PROPN
admet-2387	333	8	kasuya	kasuya	PROPN
admet-2387	333	9	,	,	PUNCT
admet-2387	333	10	m.	m.	PROPN
admet-2387	333	11	fukui	fukui	PROPN
admet-2387	333	12	,	,	PUNCT
admet-2387	333	13	e.	e.	PROPN
admet-2387	333	14	usuki	usuki	PROPN
admet-2387	333	15	,	,	PUNCT
admet-2387	333	16	n.	n.	PROPN
admet-2387	333	17	castagnoli	castagnoli	NOUN
admet-2387	333	18	.	.	PUNCT
admet-2387	334	1	studies	study	NOUN
admet-2387	334	2	on	on	ADP
admet-2387	334	3	the	the	DET
admet-2387	334	4	metabolism	metabolism	NOUN
admet-2387	334	5	of	of	ADP
admet-2387	334	6	haloperidol	haloperidol	PROPN
admet-2387	334	7	(	(	PUNCT
admet-2387	334	8	hp	hp	PROPN
admet-2387	334	9	):	):	PUNCT
admet-2387	334	10	the	the	DET
admet-2387	334	11	role	role	NOUN
admet-2387	334	12	of	of	ADP
admet-2387	334	13	cyp3a	cyp3a	NOUN
admet-2387	334	14	in	in	ADP
admet-2387	334	15	the	the	DET
admet-2387	334	16	production	production	NOUN
admet-2387	334	17	of	of	ADP
admet-2387	334	18	the	the	DET
admet-2387	334	19	neurotoxic	neurotoxic	ADJ
admet-2387	334	20	pyridinium	pyridinium	NOUN
admet-2387	334	21	metabolite	metabolite	NOUN
admet-2387	334	22	hpp+	hpp+	NOUN
admet-2387	334	23	found	find	VERB
admet-2387	334	24	in	in	ADP
admet-2387	334	25	rat	rat	NOUN
admet-2387	334	26	brain	brain	NOUN
admet-2387	334	27	following	follow	VERB
admet-2387	334	28	ip	ip	DET
admet-2387	334	29	administration	administration	NOUN
admet-2387	334	30	of	of	ADP
admet-2387	334	31	hp	hp	PROPN
admet-2387	334	32	.	.	PROPN
admet-2387	334	33	life	life	NOUN
admet-2387	334	34	sciences	science	NOUN
admet-2387	334	35	57	57	NUM
admet-2387	334	36	(	(	PUNCT
admet-2387	334	37	1995	1995	NUM
admet-2387	334	38	)	)	PUNCT
admet-2387	334	39	2439	2439	NUM
admet-2387	334	40	-	-	SYM
admet-2387	334	41	2446	2446	NUM
admet-2387	334	42	.	.	PUNCT
admet-2387	335	1	http://doi.org/10.1016/0024-3205(95)02240-5	http://doi.org/10.1016/0024-3205(95)02240-5	PROPN
admet-2387	335	2	.	.	PUNCT
admet-2387	336	1	[	[	X
admet-2387	336	2	42	42	NUM
admet-2387	336	3	]	]	PUNCT
admet-2387	336	4	k.	k.	PROPN
admet-2387	336	5	yamano	yamano	PROPN
admet-2387	336	6	,	,	PUNCT
admet-2387	336	7	k.	k.	PROPN
admet-2387	336	8	yamamoto	yamamoto	PROPN
admet-2387	336	9	,	,	PUNCT
admet-2387	336	10	h.	h.	PROPN
admet-2387	336	11	kotaki	kotaki	PROPN
admet-2387	336	12	,	,	PUNCT
admet-2387	336	13	y.	y.	PROPN
admet-2387	336	14	sawada	sawada	PROPN
admet-2387	336	15	,	,	PUNCT
admet-2387	336	16	t.	t.	PROPN
admet-2387	336	17	iga	iga	PROPN
admet-2387	336	18	.	.	PUNCT
admet-2387	337	1	quantitative	quantitative	ADJ
admet-2387	337	2	prediction	prediction	NOUN
admet-2387	337	3	of	of	ADP
admet-2387	337	4	metabolic	metabolic	NOUN
admet-2387	337	5	inhibition	inhibition	NOUN
admet-2387	337	6	of	of	ADP
admet-2387	337	7	midazolam	midazolam	PROPN
admet-2387	337	8	by	by	ADP
admet-2387	337	9	itraconazole	itraconazole	NOUN
admet-2387	337	10	and	and	CCONJ
admet-2387	337	11	ketoconazole	ketoconazole	NOUN
admet-2387	337	12	in	in	ADP
admet-2387	337	13	rats	rat	NOUN
admet-2387	337	14	:	:	PUNCT
admet-2387	337	15	implication	implication	NOUN
admet-2387	337	16	of	of	ADP
admet-2387	337	17	concentrative	concentrative	ADJ
admet-2387	337	18	uptake	uptake	NOUN
admet-2387	337	19	of	of	ADP
admet-2387	337	20	inhibitors	inhibitor	NOUN
admet-2387	337	21	into	into	ADP
admet-2387	337	22	liver	liver	NOUN
admet-2387	337	23	.	.	PUNCT
admet-2387	338	1	drug	drug	NOUN
admet-2387	338	2	metabolism	metabolism	NOUN
admet-2387	338	3	and	and	CCONJ
admet-2387	338	4	disposition	disposition	NOUN
admet-2387	338	5	27	27	NUM
admet-2387	338	6	(	(	PUNCT
admet-2387	338	7	1999	1999	NUM
admet-2387	338	8	)	)	PUNCT
admet-2387	338	9	395	395	NUM
admet-2387	338	10	-	-	SYM
admet-2387	338	11	402	402	NUM
admet-2387	338	12	.	.	PUNCT
admet-2387	339	1	https://pubmed.ncbi.nlm.nih.gov/10064572/.	https://pubmed.ncbi.nlm.nih.gov/10064572/.	PRON
admet-2387	340	1	[	[	X
admet-2387	340	2	43	43	NUM
admet-2387	340	3	]	]	X
admet-2387	340	4	r.b	r.b	PROPN
admet-2387	340	5	.	.	PROPN
admet-2387	340	6	ewesuedo	ewesuedo	PROPN
admet-2387	340	7	,	,	PUNCT
admet-2387	340	8	m.e	m.e	PROPN
admet-2387	340	9	.	.	PROPN
admet-2387	340	10	dolan	dolan	PROPN
admet-2387	340	11	.	.	PUNCT
admet-2387	341	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	341	2	of	of	ADP
admet-2387	341	3	oral	oral	ADJ
admet-2387	341	4	o6	o6	NOUN
admet-2387	341	5	-	-	PUNCT
admet-2387	341	6	benzylguanine	benzylguanine	NOUN
admet-2387	341	7	and	and	CCONJ
admet-2387	341	8	evidence	evidence	NOUN
admet-2387	341	9	of	of	ADP
admet-2387	341	10	interaction	interaction	NOUN
admet-2387	341	11	with	with	ADP
admet-2387	341	12	oral	oral	ADJ
admet-2387	341	13	ketoconazole	ketoconazole	NOUN
admet-2387	341	14	in	in	ADP
admet-2387	341	15	the	the	DET
admet-2387	341	16	rat	rat	NOUN
admet-2387	341	17	.	.	PUNCT
admet-2387	341	18	cancer	cancer	NOUN
admet-2387	341	19	chemotherapy	chemotherapy	NOUN
admet-2387	341	20	and	and	CCONJ
admet-2387	341	21	pharmacology	pharmacology	NOUN
admet-2387	341	22	46	46	NUM
admet-2387	341	23	(	(	PUNCT
admet-2387	341	24	2000	2000	NUM
admet-2387	341	25	)	)	PUNCT
admet-2387	341	26	150	150	NUM
admet-2387	341	27	-	-	SYM
admet-2387	341	28	155	155	NUM
admet-2387	341	29	.	.	PUNCT
admet-2387	342	1	http://doi.org/10.1007/s002800000121	http://doi.org/10.1007/s002800000121	NUM
admet-2387	342	2	.	.	PUNCT
admet-2387	343	1	[	[	X
admet-2387	343	2	44	44	NUM
admet-2387	343	3	]	]	PUNCT
admet-2387	343	4	k.	k.	PROPN
admet-2387	344	1	he	he	PROPN
admet-2387	344	2	,	,	PUNCT
admet-2387	344	3	t.f	t.f	PROPN
admet-2387	344	4	.	.	PROPN
admet-2387	344	5	woolf	woolf	PROPN
admet-2387	344	6	,	,	PUNCT
admet-2387	344	7	e.k	e.k	PROPN
admet-2387	344	8	.	.	PROPN
admet-2387	344	9	kindt	kindt	PROPN
admet-2387	344	10	,	,	PUNCT
admet-2387	344	11	a.e	a.e	PROPN
admet-2387	344	12	.	.	PROPN
admet-2387	344	13	fielder	fielder	NOUN
admet-2387	344	14	,	,	PUNCT
admet-2387	344	15	r.e	r.e	PROPN
admet-2387	344	16	.	.	PROPN
admet-2387	344	17	talaat	talaat	PROPN
admet-2387	344	18	.	.	PUNCT
admet-2387	345	1	troglitazone	troglitazone	NOUN
admet-2387	345	2	quinone	quinone	NOUN
admet-2387	345	3	formation	formation	NOUN
admet-2387	345	4	catalyzed	catalyze	VERB
admet-2387	345	5	by	by	ADP
admet-2387	345	6	human	human	ADJ
admet-2387	345	7	and	and	CCONJ
admet-2387	345	8	rat	rat	NOUN
admet-2387	345	9	cyp3a	cyp3a	PROPN
admet-2387	345	10	:	:	PUNCT
admet-2387	345	11	an	an	DET
admet-2387	345	12	atypical	atypical	ADJ
admet-2387	345	13	cyp	cyp	ADJ
admet-2387	345	14	oxidation	oxidation	NOUN
admet-2387	345	15	reaction	reaction	NOUN
admet-2387	345	16	.	.	PUNCT
admet-2387	346	1	biochemical	biochemical	ADJ
admet-2387	346	2	pharmacology	pharmacology	NOUN
admet-2387	346	3	62	62	NUM
admet-2387	346	4	(	(	PUNCT
admet-2387	346	5	2001	2001	NUM
admet-2387	346	6	)	)	PUNCT
admet-2387	346	7	191	191	NUM
admet-2387	346	8	-	-	SYM
admet-2387	346	9	198	198	NUM
admet-2387	346	10	.	.	PUNCT
admet-2387	347	1	http://doi.org/10.1016/s0006-2952(01)00653-0	http://doi.org/10.1016/s0006-2952(01)00653-0	PROPN
admet-2387	347	2	.	.	PUNCT
admet-2387	347	3	http://doi.org/10.1002/chir.20669	http://doi.org/10.1002/chir.20669	PROPN
admet-2387	348	1	http://doi.org/10.3109/00498254.2010.529178	http://doi.org/10.3109/00498254.2010.529178	AUX
admet-2387	349	1	http://doi.org/10.1111/j.1365-2125.1994.tb04317.x	http://doi.org/10.1111/j.1365-2125.1994.tb04317.x	INTJ
admet-2387	349	2	http://doi.org/10.1111/j.1365-2125.1994.tb04317.x	http://doi.org/10.1111/j.1365-2125.1994.tb04317.x	PROPN
admet-2387	349	3	http://doi.org/10.1016/s0399-077x(85)80039-1	http://doi.org/10.1016/s0399-077x(85)80039-1	PROPN
admet-2387	349	4	http://doi.org/10.1016/s0399-077x(85)80039-1	http://doi.org/10.1016/s0399-077x(85)80039-1	PROPN
admet-2387	349	5	https://pubmed.ncbi.nlm.nih.gov/	https://pubmed.ncbi.nlm.nih.gov/	PROPN
admet-2387	349	6	http://doi.org/10.1023/a:1018966800208	http://doi.org/10.1023/a:1018966800208	ADJ
admet-2387	349	7	http://doi.org/10.1073/pnas.97.2.925	http://doi.org/10.1073/pnas.97.2.925	PROPN
admet-2387	349	8	http://doi.org/10.1016/0024-3205(95)02240-5	http://doi.org/10.1016/0024-3205(95)02240-5	NOUN
admet-2387	349	9	http://doi.org/10.1007/s002800000121	http://doi.org/10.1007/s002800000121	NUM
admet-2387	349	10	http://doi.org/10.1016/s0006-2952(01)00653-0	http://doi.org/10.1016/s0006-2952(01)00653-0	NOUN
admet-2387	349	11	admet	admet	PROPN
admet-2387	349	12	&	&	CCONJ
admet-2387	349	13	dmpk	dmpk	PROPN
admet-2387	349	14	12(6	12(6	NUM
admet-2387	349	15	)	)	PUNCT
admet-2387	349	16	(	(	PUNCT
admet-2387	349	17	2024	2024	NUM
admet-2387	349	18	)	)	PUNCT
admet-2387	349	19	943	943	NUM
admet-2387	349	20	-	-	SYM
admet-2387	349	21	955	955	NUM
admet-2387	349	22	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	349	23	and	and	CCONJ
admet-2387	349	24	metabolism	metabolism	NOUN
admet-2387	349	25	of	of	ADP
admet-2387	349	26	ketoconazole	ketoconazole	PROPN
admet-2387	349	27	doi	doi	PROPN
admet-2387	349	28	:	:	PUNCT
admet-2387	349	29	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	349	30	955	955	NUM
admet-2387	349	31	[	[	X
admet-2387	349	32	45	45	NUM
admet-2387	349	33	]	]	PUNCT
admet-2387	349	34	t.	t.	NOUN
admet-2387	349	35	kotegawa	kotegawa	PROPN
admet-2387	349	36	,	,	PUNCT
admet-2387	349	37	b.e	b.e	PROPN
admet-2387	349	38	.	.	PROPN
admet-2387	349	39	laurijssens	laurijssens	PROPN
admet-2387	349	40	,	,	PUNCT
admet-2387	349	41	l.l	l.l	PROPN
admet-2387	349	42	.	.	PROPN
admet-2387	349	43	von	von	PROPN
admet-2387	349	44	moltke	moltke	PROPN
admet-2387	349	45	,	,	PUNCT
admet-2387	349	46	m.m	m.m	PROPN
admet-2387	349	47	.	.	PROPN
admet-2387	349	48	cotreau	cotreau	PROPN
admet-2387	349	49	,	,	PUNCT
admet-2387	349	50	m.d	m.d	PROPN
admet-2387	349	51	.	.	PROPN
admet-2387	349	52	perloff	perloff	PROPN
admet-2387	349	53	,	,	PUNCT
admet-2387	349	54	k.	k.	PROPN
admet-2387	349	55	venkatakrishnan	venkatakrishnan	PROPN
admet-2387	349	56	,	,	PUNCT
admet-2387	349	57	j.s	j.s	PROPN
admet-2387	349	58	.	.	PROPN
admet-2387	349	59	warrington	warrington	PROPN
admet-2387	349	60	,	,	PUNCT
admet-2387	349	61	b.w	b.w	PROPN
admet-2387	349	62	.	.	PROPN
admet-2387	349	63	granda	granda	PROPN
admet-2387	349	64	,	,	PUNCT
admet-2387	349	65	j.s	j.s	PROPN
admet-2387	349	66	.	.	PROPN
admet-2387	349	67	harmatz	harmatz	PROPN
admet-2387	349	68	,	,	PUNCT
admet-2387	349	69	d.j	d.j	PROPN
admet-2387	349	70	.	.	PROPN
admet-2387	349	71	greenblatt	greenblatt	PROPN
admet-2387	349	72	.	.	PUNCT
admet-2387	350	1	in	in	ADP
admet-2387	350	2	vitro	vitro	X
admet-2387	350	3	,	,	PUNCT
admet-2387	350	4	pharmacokinetic	pharmacokinetic	ADJ
admet-2387	350	5	,	,	PUNCT
admet-2387	350	6	and	and	CCONJ
admet-2387	350	7	pharmacodynamic	pharmacodynamic	ADJ
admet-2387	350	8	interactions	interaction	NOUN
admet-2387	350	9	of	of	ADP
admet-2387	350	10	ketoconazole	ketoconazole	NOUN
admet-2387	350	11	and	and	CCONJ
admet-2387	350	12	midazolam	midazolam	PROPN
admet-2387	350	13	in	in	ADP
admet-2387	350	14	the	the	DET
admet-2387	350	15	rat	rat	PROPN
admet-2387	350	16	.	.	PROPN
admet-2387	350	17	journal	journal	PROPN
admet-2387	350	18	of	of	ADP
admet-2387	350	19	pharmacology	pharmacology	NOUN
admet-2387	350	20	and	and	CCONJ
admet-2387	350	21	experimental	experimental	ADJ
admet-2387	350	22	therapeutics	therapeutic	NOUN
admet-2387	350	23	302	302	NUM
admet-2387	350	24	(	(	PUNCT
admet-2387	350	25	2002	2002	NUM
admet-2387	350	26	)	)	PUNCT
admet-2387	350	27	1228	1228	NUM
admet-2387	350	28	-	-	SYM
admet-2387	350	29	1237	1237	NUM
admet-2387	350	30	.	.	PUNCT
admet-2387	351	1	http://doi.org/10.1124/jpet.102.035972	http://doi.org/10.1124/jpet.102.035972	PROPN
admet-2387	351	2	.	.	PUNCT
admet-2387	352	1	[	[	X
admet-2387	352	2	46	46	NUM
admet-2387	352	3	]	]	PUNCT
admet-2387	352	4	a.	a.	NOUN
admet-2387	352	5	walubo	walubo	PROPN
admet-2387	352	6	,	,	PUNCT
admet-2387	352	7	s.	s.	PROPN
admet-2387	352	8	barr	barr	PROPN
admet-2387	352	9	,	,	PUNCT
admet-2387	352	10	a.m.	a.m.	PROPN
admet-2387	352	11	abraham	abraham	PROPN
admet-2387	352	12	,	,	PUNCT
admet-2387	352	13	c.	c.	PROPN
admet-2387	352	14	coetsee	coetsee	PROPN
admet-2387	352	15	.	.	PUNCT
admet-2387	353	1	the	the	DET
admet-2387	353	2	role	role	NOUN
admet-2387	353	3	of	of	ADP
admet-2387	353	4	cytochrome	cytochrome	NOUN
admet-2387	353	5	-	-	PUNCT
admet-2387	353	6	p450	p450	PROPN
admet-2387	353	7	inhibitors	inhibitor	NOUN
admet-2387	353	8	in	in	ADP
admet-2387	353	9	the	the	DET
admet-2387	353	10	prevention	prevention	NOUN
admet-2387	353	11	of	of	ADP
admet-2387	353	12	hepatotoxicity	hepatotoxicity	NOUN
admet-2387	353	13	after	after	ADP
admet-2387	353	14	paracetamol	paracetamol	NOUN
admet-2387	353	15	overdose	overdose	ADV
admet-2387	353	16	in	in	ADP
admet-2387	353	17	rats	rat	NOUN
admet-2387	353	18	.	.	PUNCT
admet-2387	354	1	human	human	ADJ
admet-2387	354	2	and	and	CCONJ
admet-2387	354	3	experimental	experimental	ADJ
admet-2387	354	4	toxicology	toxicology	NOUN
admet-2387	354	5	23	23	NUM
admet-2387	354	6	(	(	PUNCT
admet-2387	354	7	2004	2004	NUM
admet-2387	354	8	)	)	PUNCT
admet-2387	354	9	49	49	NUM
admet-2387	354	10	-	-	SYM
admet-2387	354	11	54	54	NUM
admet-2387	354	12	.	.	PUNCT
admet-2387	355	1	http://doi.org/10.1191/0960327104ht415oa	http://doi.org/10.1191/0960327104ht415oa	PROPN
admet-2387	355	2	.	.	PUNCT
admet-2387	356	1	[	[	X
admet-2387	356	2	47	47	NUM
admet-2387	356	3	]	]	X
admet-2387	356	4	y.j	y.j	PROPN
admet-2387	356	5	.	.	PUNCT
admet-2387	356	6	li	li	PROPN
admet-2387	356	7	,	,	PUNCT
admet-2387	356	8	h.m	h.m	PROPN
admet-2387	356	9	.	.	PROPN
admet-2387	356	10	shaw	shaw	PROPN
admet-2387	356	11	.	.	PUNCT
admet-2387	357	1	pregnenolone	pregnenolone	NOUN
admet-2387	357	2	and	and	CCONJ
admet-2387	357	3	dexamethasone	dexamethasone	NOUN
admet-2387	357	4	,	,	PUNCT
admet-2387	357	5	modulators	modulator	NOUN
admet-2387	357	6	of	of	ADP
admet-2387	357	7	cytochrome	cytochrome	ADJ
admet-2387	357	8	p450	p450	PROPN
admet-2387	357	9	-	-	PUNCT
admet-2387	357	10	3a	3a	NUM
admet-2387	357	11	,	,	PUNCT
admet-2387	357	12	not	not	PART
admet-2387	357	13	increase	increase	VERB
admet-2387	357	14	but	but	CCONJ
admet-2387	357	15	reduce	reduce	VERB
admet-2387	357	16	urinary	urinary	ADJ
admet-2387	357	17	α	α	NOUN
admet-2387	357	18	-	-	PUNCT
admet-2387	357	19	cehc	cehc	NOUN
admet-2387	357	20	excretion	excretion	NOUN
admet-2387	357	21	in	in	ADP
admet-2387	357	22	rats	rat	NOUN
admet-2387	357	23	.	.	PUNCT
admet-2387	358	1	biofactors	biofactor	NOUN
admet-2387	358	2	31	31	NUM
admet-2387	358	3	(	(	PUNCT
admet-2387	358	4	2007	2007	NUM
admet-2387	358	5	)	)	PUNCT
admet-2387	358	6	67	67	NUM
admet-2387	358	7	-	-	SYM
admet-2387	358	8	76	76	NUM
admet-2387	358	9	.	.	PUNCT
admet-2387	359	1	http://doi.org/10.1002/biof.5520310107	http://doi.org/10.1002/biof.5520310107	NOUN
admet-2387	359	2	.	.	PUNCT
admet-2387	360	1	[	[	X
admet-2387	360	2	48	48	NUM
admet-2387	360	3	]	]	X
admet-2387	360	4	x.h	x.h	PROPN
admet-2387	360	5	.	.	PROPN
admet-2387	360	6	ren	ren	PROPN
admet-2387	360	7	,	,	PUNCT
admet-2387	360	8	l.q	l.q	PROPN
admet-2387	360	9	.	.	PROPN
admet-2387	360	10	si	si	PROPN
admet-2387	360	11	,	,	PUNCT
admet-2387	360	12	l.	l.	PROPN
admet-2387	360	13	cao	cao	PROPN
admet-2387	360	14	,	,	PUNCT
admet-2387	360	15	j.	j.	PROPN
admet-2387	360	16	yao	yao	PROPN
admet-2387	360	17	,	,	PUNCT
admet-2387	360	18	j.	j.	PROPN
admet-2387	360	19	qiu	qiu	PROPN
admet-2387	360	20	,	,	PUNCT
admet-2387	360	21	g.	g.	PROPN
admet-2387	360	22	li	li	PROPN
admet-2387	360	23	.	.	PROPN
admet-2387	360	24	effect	effect	NOUN
admet-2387	360	25	of	of	ADP
admet-2387	360	26	polyoxyl	polyoxyl	NOUN
admet-2387	360	27	ether	ether	NOUN
admet-2387	360	28	analogous	analogous	ADJ
admet-2387	360	29	surfactants	surfactant	NOUN
admet-2387	360	30	on	on	ADP
admet-2387	360	31	the	the	DET
admet-2387	360	32	activity	activity	NOUN
admet-2387	360	33	of	of	ADP
admet-2387	360	34	cytochromes	cytochrome	NOUN
admet-2387	360	35	p450	p450	PROPN
admet-2387	360	36	3a	3a	NUM
admet-2387	360	37	in	in	ADP
admet-2387	360	38	rats	rat	NOUN
admet-2387	360	39	in	in	ADP
admet-2387	360	40	vivo	vivo	NOUN
admet-2387	360	41	.	.	PUNCT
admet-2387	361	1	yaoxue	yaoxue	NOUN
admet-2387	361	2	xuebao	xuebao	PROPN
admet-2387	361	3	43	43	NUM
admet-2387	361	4	(	(	PUNCT
admet-2387	361	5	2008	2008	NUM
admet-2387	361	6	)	)	PUNCT
admet-2387	361	7	528	528	NUM
admet-2387	361	8	-	-	SYM
admet-2387	361	9	534	534	NUM
admet-2387	361	10	.	.	PUNCT
admet-2387	362	1	https://pubmed.ncbi.nlm.nih.gov/18717343/.	https://pubmed.ncbi.nlm.nih.gov/18717343/.	PUNCT
admet-2387	362	2	[	[	X
admet-2387	362	3	49	49	NUM
admet-2387	362	4	]	]	X
admet-2387	362	5	v.b	v.b	PROPN
admet-2387	362	6	.	.	PROPN
admet-2387	362	7	boralli	boralli	PROPN
admet-2387	362	8	,	,	PUNCT
admet-2387	362	9	e.b	e.b	PROPN
admet-2387	362	10	.	.	PROPN
admet-2387	362	11	coelho	coelho	PROPN
admet-2387	362	12	,	,	PUNCT
admet-2387	362	13	v.l	v.l	PROPN
admet-2387	362	14	.	.	PROPN
admet-2387	362	15	lanchote	lanchote	NOUN
admet-2387	362	16	.	.	PUNCT
admet-2387	363	1	influence	influence	NOUN
admet-2387	363	2	of	of	ADP
admet-2387	363	3	quinidine	quinidine	PROPN
admet-2387	363	4	,	,	PUNCT
admet-2387	363	5	cimetidine	cimetidine	NOUN
admet-2387	363	6	,	,	PUNCT
admet-2387	363	7	and	and	CCONJ
admet-2387	363	8	ketoconazole	ketoconazole	NOUN
admet-2387	363	9	on	on	ADP
admet-2387	363	10	the	the	DET
admet-2387	363	11	enantioselective	enantioselective	ADJ
admet-2387	363	12	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	363	13	and	and	CCONJ
admet-2387	363	14	metabolism	metabolism	NOUN
admet-2387	363	15	of	of	ADP
admet-2387	363	16	metoprolol	metoprolol	NOUN
admet-2387	363	17	in	in	ADP
admet-2387	363	18	rats	rat	NOUN
admet-2387	363	19	.	.	PUNCT
admet-2387	364	1	chirality	chirality	NOUN
admet-2387	364	2	21	21	NUM
admet-2387	364	3	(	(	PUNCT
admet-2387	364	4	2009	2009	NUM
admet-2387	364	5	)	)	PUNCT
admet-2387	364	6	886893	886893	NUM
admet-2387	364	7	.	.	PUNCT
admet-2387	365	1	http://doi.org/10.1002/chir.20682	http://doi.org/10.1002/chir.20682	NOUN
admet-2387	365	2	.	.	PUNCT
admet-2387	366	1	[	[	X
admet-2387	366	2	50	50	NUM
admet-2387	366	3	]	]	X
admet-2387	366	4	x.f	x.f	PROPN
admet-2387	366	5	.	.	PROPN
admet-2387	366	6	zhang	zhang	PROPN
admet-2387	366	7	,	,	PUNCT
admet-2387	366	8	j.	j.	PROPN
admet-2387	366	9	liu	liu	PROPN
admet-2387	366	10	,	,	PUNCT
admet-2387	366	11	f.	f.	PROPN
admet-2387	366	12	ye	ye	PROPN
admet-2387	366	13	,	,	PUNCT
admet-2387	366	14	s.g	s.g	PROPN
admet-2387	366	15	.	.	PROPN
admet-2387	366	16	ji	ji	PROPN
admet-2387	366	17	,	,	PUNCT
admet-2387	366	18	n.	n.	PROPN
admet-2387	366	19	zhang	zhang	PROPN
admet-2387	366	20	,	,	PUNCT
admet-2387	366	21	r.	r.	PROPN
admet-2387	366	22	sen	sen	PROPN
admet-2387	366	23	cao	cao	PROPN
admet-2387	366	24	,	,	PUNCT
admet-2387	366	25	l.	l.	PROPN
admet-2387	366	26	he	he	PRON
admet-2387	366	27	,	,	PUNCT
admet-2387	366	28	j.c	j.c	PROPN
admet-2387	366	29	.	.	PROPN
admet-2387	366	30	wu	wu	PROPN
admet-2387	366	31	,	,	PUNCT
admet-2387	366	32	x.f	x.f	PROPN
admet-2387	366	33	.	.	PROPN
admet-2387	366	34	li	li	PROPN
admet-2387	366	35	.	.	PUNCT
admet-2387	366	36	effects	effect	NOUN
admet-2387	366	37	of	of	ADP
admet-2387	366	38	triptolide	triptolide	NOUN
admet-2387	366	39	on	on	ADP
admet-2387	366	40	the	the	DET
admet-2387	366	41	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	366	42	of	of	ADP
admet-2387	366	43	cyclophosphamide	cyclophosphamide	NOUN
admet-2387	366	44	in	in	ADP
admet-2387	366	45	rats	rat	NOUN
admet-2387	366	46	:	:	PUNCT
admet-2387	366	47	a	a	DET
admet-2387	366	48	possible	possible	ADJ
admet-2387	366	49	role	role	NOUN
admet-2387	366	50	of	of	ADP
admet-2387	366	51	cytochromep3a4	cytochromep3a4	NOUN
admet-2387	366	52	inhibition	inhibition	NOUN
admet-2387	366	53	.	.	PUNCT
admet-2387	367	1	chinese	chinese	ADJ
admet-2387	367	2	journal	journal	PROPN
admet-2387	367	3	of	of	ADP
admet-2387	367	4	integrative	integrative	ADJ
admet-2387	367	5	medicine	medicine	NOUN
admet-2387	367	6	20	20	NUM
admet-2387	367	7	(	(	PUNCT
admet-2387	367	8	2014	2014	NUM
admet-2387	367	9	)	)	PUNCT
admet-2387	367	10	534	534	NUM
admet-2387	367	11	-	-	SYM
admet-2387	367	12	539	539	NUM
admet-2387	367	13	.	.	PUNCT
admet-2387	368	1	http://doi.org/10.1007/s11655-0141710-0	http://doi.org/10.1007/s11655-0141710-0	ADV
admet-2387	368	2	.	.	PUNCT
admet-2387	369	1	[	[	X
admet-2387	369	2	51	51	NUM
admet-2387	369	3	]	]	PUNCT
admet-2387	369	4	l.	l.	PROPN
admet-2387	369	5	wang	wang	PROPN
admet-2387	369	6	,	,	PUNCT
admet-2387	369	7	s.	s.	PROPN
admet-2387	369	8	wang	wang	PROPN
admet-2387	369	9	,	,	PUNCT
admet-2387	369	10	m.	m.	PROPN
admet-2387	369	11	chen	chen	PROPN
admet-2387	369	12	,	,	PUNCT
admet-2387	369	13	x.	x.	PROPN
admet-2387	369	14	chen	chen	PROPN
admet-2387	369	15	,	,	PUNCT
admet-2387	369	16	y.	y.	PROPN
admet-2387	369	17	lin	lin	PROPN
admet-2387	369	18	,	,	PUNCT
admet-2387	369	19	x.	x.	PROPN
admet-2387	369	20	hu	hu	PROPN
admet-2387	369	21	,	,	PUNCT
admet-2387	369	22	x.	x.	PROPN
admet-2387	369	23	huang	huang	PROPN
admet-2387	369	24	,	,	PUNCT
admet-2387	369	25	x.	x.	PROPN
admet-2387	369	26	li	li	PROPN
admet-2387	369	27	,	,	PUNCT
admet-2387	369	28	g.	g.	PROPN
admet-2387	369	29	hu	hu	PROPN
admet-2387	369	30	.	.	PROPN
admet-2387	369	31	inhibitory	inhibitory	ADJ
admet-2387	369	32	effect	effect	NOUN
admet-2387	369	33	of	of	ADP
admet-2387	369	34	ketoconazole	ketoconazole	NOUN
admet-2387	369	35	and	and	CCONJ
admet-2387	369	36	voriconazole	voriconazole	NOUN
admet-2387	369	37	on	on	ADP
admet-2387	369	38	the	the	DET
admet-2387	369	39	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	369	40	of	of	ADP
admet-2387	369	41	carvedilol	carvedilol	NOUN
admet-2387	369	42	in	in	ADP
admet-2387	369	43	rats	rat	NOUN
admet-2387	369	44	.	.	PUNCT
admet-2387	370	1	drug	drug	NOUN
admet-2387	370	2	development	development	NOUN
admet-2387	370	3	and	and	CCONJ
admet-2387	370	4	industrial	industrial	ADJ
admet-2387	370	5	pharmacy	pharmacy	NOUN
admet-2387	370	6	41	41	NUM
admet-2387	370	7	(	(	PUNCT
admet-2387	370	8	2015	2015	NUM
admet-2387	370	9	)	)	PUNCT
admet-2387	370	10	1661	1661	NUM
admet-2387	370	11	-	-	SYM
admet-2387	370	12	1666	1666	NUM
admet-2387	370	13	.	.	PUNCT
admet-2387	371	1	http://doi.org/10.3109/03639045.2014.983930	http://doi.org/10.3109/03639045.2014.983930	PROPN
admet-2387	371	2	.	.	PUNCT
admet-2387	372	1	[	[	X
admet-2387	372	2	52	52	NUM
admet-2387	372	3	]	]	PUNCT
admet-2387	372	4	a.	a.	PROPN
admet-2387	372	5	iida	iida	PROPN
admet-2387	372	6	,	,	PUNCT
admet-2387	372	7	e.	e.	PROPN
admet-2387	372	8	sasaki	sasaki	PROPN
admet-2387	372	9	,	,	PUNCT
admet-2387	372	10	a.	a.	PROPN
admet-2387	372	11	yano	yano	PROPN
admet-2387	372	12	,	,	PUNCT
admet-2387	372	13	k.	k.	PROPN
admet-2387	372	14	tsuneyama	tsuneyama	PROPN
admet-2387	372	15	,	,	PUNCT
admet-2387	372	16	t.	t.	PROPN
admet-2387	372	17	fukami	fukami	PROPN
admet-2387	372	18	,	,	PUNCT
admet-2387	372	19	m.	m.	NOUN
admet-2387	372	20	nakajima	nakajima	PROPN
admet-2387	372	21	,	,	PUNCT
admet-2387	372	22	t.	t.	PROPN
admet-2387	372	23	yokoi	yokoi	PROPN
admet-2387	372	24	.	.	PUNCT
admet-2387	373	1	carbamazepine	carbamazepine	NOUN
admet-2387	373	2	-	-	PUNCT
admet-2387	373	3	induced	induce	VERB
admet-2387	373	4	liver	liver	NOUN
admet-2387	373	5	injury	injury	NOUN
admet-2387	373	6	requires	require	VERB
admet-2387	373	7	cyp3a	cyp3a	NOUN
admet-2387	373	8	-	-	PUNCT
admet-2387	373	9	mediated	mediate	VERB
admet-2387	373	10	metabolism	metabolism	NOUN
admet-2387	373	11	and	and	CCONJ
admet-2387	373	12	glutathione	glutathione	NOUN
admet-2387	373	13	depletion	depletion	NOUN
admet-2387	373	14	in	in	ADP
admet-2387	373	15	rats	rat	NOUN
admet-2387	373	16	.	.	PUNCT
admet-2387	374	1	drug	drug	NOUN
admet-2387	374	2	metabolism	metabolism	NOUN
admet-2387	374	3	and	and	CCONJ
admet-2387	374	4	disposition	disposition	NOUN
admet-2387	374	5	43	43	NUM
admet-2387	374	6	(	(	PUNCT
admet-2387	374	7	2015	2015	NUM
admet-2387	374	8	)	)	PUNCT
admet-2387	374	9	958	958	NUM
admet-2387	374	10	-	-	SYM
admet-2387	374	11	968	968	NUM
admet-2387	374	12	.	.	PUNCT
admet-2387	375	1	http://doi.org/10.1124/dmd.115.063370	http://doi.org/10.1124/dmd.115.063370	INTJ
admet-2387	375	2	.	.	PUNCT
admet-2387	376	1	[	[	X
admet-2387	376	2	53	53	NUM
admet-2387	376	3	]	]	PUNCT
admet-2387	376	4	x.	x.	PROPN
admet-2387	376	5	chen	chen	PROPN
admet-2387	376	6	,	,	PUNCT
admet-2387	376	7	e.	e.	PROPN
admet-2387	376	8	gu	gu	PROPN
admet-2387	376	9	,	,	PUNCT
admet-2387	376	10	s.	s.	PROPN
admet-2387	376	11	wang	wang	PROPN
admet-2387	376	12	,	,	PUNCT
admet-2387	376	13	x.	x.	PROPN
admet-2387	376	14	zheng	zheng	PROPN
admet-2387	376	15	,	,	PUNCT
admet-2387	376	16	m.	m.	PROPN
admet-2387	376	17	chen	chen	PROPN
admet-2387	376	18	,	,	PUNCT
admet-2387	376	19	l.	l.	PROPN
admet-2387	376	20	wang	wang	PROPN
admet-2387	376	21	,	,	PUNCT
admet-2387	376	22	g.	g.	PROPN
admet-2387	376	23	hu	hu	PROPN
admet-2387	376	24	,	,	PUNCT
admet-2387	376	25	j.p	j.p	PROPN
admet-2387	376	26	.	.	PROPN
admet-2387	376	27	cai	cai	PROPN
admet-2387	376	28	,	,	PUNCT
admet-2387	376	29	h.	h.	PROPN
admet-2387	376	30	zhou	zhou	PROPN
admet-2387	376	31	.	.	PUNCT
admet-2387	377	1	evaluation	evaluation	NOUN
admet-2387	377	2	of	of	ADP
admet-2387	377	3	the	the	DET
admet-2387	377	4	effects	effect	NOUN
admet-2387	377	5	of	of	ADP
admet-2387	377	6	ketoconazole	ketoconazole	NOUN
admet-2387	377	7	and	and	CCONJ
admet-2387	377	8	voriconazole	voriconazole	NOUN
admet-2387	377	9	on	on	ADP
admet-2387	377	10	the	the	DET
admet-2387	377	11	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	377	12	of	of	ADP
admet-2387	377	13	oxcarbazepine	oxcarbazepine	NOUN
admet-2387	377	14	and	and	CCONJ
admet-2387	377	15	its	its	PRON
admet-2387	377	16	main	main	ADJ
admet-2387	377	17	metabolite	metabolite	NOUN
admet-2387	377	18	mhd	mhd	NOUN
admet-2387	377	19	in	in	ADP
admet-2387	377	20	rats	rat	NOUN
admet-2387	377	21	by	by	ADP
admet-2387	377	22	uplc	uplc	ADJ
admet-2387	377	23	-	-	PUNCT
admet-2387	377	24	ms	ms	PROPN
admet-2387	377	25	-	-	PUNCT
admet-2387	377	26	ms	ms	PROPN
admet-2387	377	27	.	.	PROPN
admet-2387	377	28	journal	journal	PROPN
admet-2387	377	29	of	of	ADP
admet-2387	377	30	chromatographic	chromatographic	ADJ
admet-2387	377	31	science	science	NOUN
admet-2387	377	32	54	54	NUM
admet-2387	377	33	(	(	PUNCT
admet-2387	377	34	2016	2016	NUM
admet-2387	377	35	)	)	PUNCT
admet-2387	377	36	334	334	NUM
admet-2387	377	37	-	-	SYM
admet-2387	377	38	342	342	NUM
admet-2387	377	39	.	.	PUNCT
admet-2387	378	1	http://doi.org/10.1093/chromsci/bmv146	http://doi.org/10.1093/chromsci/bmv146	NOUN
admet-2387	378	2	.	.	PUNCT
admet-2387	379	1	[	[	X
admet-2387	379	2	54	54	NUM
admet-2387	379	3	]	]	PUNCT
admet-2387	379	4	k.	k.	PROPN
admet-2387	379	5	ren	ren	PROPN
admet-2387	379	6	,	,	PUNCT
admet-2387	379	7	r.	r.	PROPN
admet-2387	379	8	wang	wang	PROPN
admet-2387	379	9	,	,	PUNCT
admet-2387	379	10	s.	s.	PROPN
admet-2387	379	11	fang	fang	PROPN
admet-2387	379	12	,	,	PUNCT
admet-2387	379	13	s.	s.	PROPN
admet-2387	379	14	ren	ren	PROPN
admet-2387	379	15	,	,	PUNCT
admet-2387	379	16	h.	h.	PROPN
admet-2387	379	17	hua	hua	PROPN
admet-2387	379	18	,	,	PUNCT
admet-2387	379	19	d.	d.	PROPN
admet-2387	379	20	wang	wang	PROPN
admet-2387	379	21	,	,	PUNCT
admet-2387	379	22	y.	y.	PROPN
admet-2387	379	23	pan	pan	PROPN
admet-2387	379	24	,	,	PUNCT
admet-2387	379	25	x.	x.	PROPN
admet-2387	379	26	liu	liu	PROPN
admet-2387	379	27	.	.	PUNCT
admet-2387	380	1	effect	effect	NOUN
admet-2387	380	2	of	of	ADP
admet-2387	380	3	cyp3a	cyp3a	NOUN
admet-2387	380	4	inducer	inducer	NOUN
admet-2387	380	5	/	/	SYM
admet-2387	380	6	inhibitor	inhibitor	NOUN
admet-2387	380	7	and	and	CCONJ
admet-2387	380	8	licorice	licorice	NOUN
admet-2387	380	9	on	on	ADP
admet-2387	380	10	hepatotoxicity	hepatotoxicity	NOUN
admet-2387	380	11	and	and	CCONJ
admet-2387	380	12	in	in	ADP
admet-2387	380	13	vivo	vivo	ADJ
admet-2387	380	14	metabolism	metabolism	NOUN
admet-2387	380	15	of	of	ADP
admet-2387	380	16	main	main	ADJ
admet-2387	380	17	alkaloids	alkaloid	NOUN
admet-2387	380	18	of	of	ADP
admet-2387	380	19	euodiae	euodiae	PROPN
admet-2387	380	20	fructus	fructus	NOUN
admet-2387	380	21	based	base	VERB
admet-2387	380	22	on	on	ADP
admet-2387	380	23	uplc	uplc	ADJ
admet-2387	380	24	-	-	PUNCT
admet-2387	380	25	q	q	NOUN
admet-2387	380	26	-	-	PUNCT
admet-2387	380	27	exactive	exactive	ADJ
admet-2387	380	28	-	-	PUNCT
admet-2387	380	29	ms	ms	PROPN
admet-2387	380	30	.	.	PROPN
admet-2387	380	31	journal	journal	PROPN
admet-2387	380	32	of	of	ADP
admet-2387	380	33	ethnopharmacology	ethnopharmacology	NOUN
admet-2387	380	34	303	303	NUM
admet-2387	380	35	(	(	PUNCT
admet-2387	380	36	2023	2023	NUM
admet-2387	380	37	)	)	PUNCT
admet-2387	380	38	116005	116005	NUM
admet-2387	380	39	.	.	PUNCT
admet-2387	381	1	http://doi.org/10.1016/j.jep.2022.116005	http://doi.org/10.1016/j.jep.2022.116005	X
admet-2387	381	2	.	.	PUNCT
admet-2387	382	1	[	[	X
admet-2387	382	2	55	55	NUM
admet-2387	382	3	]	]	X
admet-2387	382	4	a.l	a.l	PROPN
admet-2387	382	5	.	.	PROPN
admet-2387	382	6	cirello	cirello	PROPN
admet-2387	382	7	,	,	PUNCT
admet-2387	382	8	j.l	j.l	PROPN
admet-2387	382	9	.	.	PROPN
admet-2387	382	10	dumouchel	dumouchel	PROPN
admet-2387	382	11	,	,	PUNCT
admet-2387	382	12	m.	m.	NOUN
admet-2387	382	13	gunduz	gunduz	PROPN
admet-2387	382	14	,	,	PUNCT
admet-2387	382	15	c.e	c.e	PROPN
admet-2387	382	16	.	.	PROPN
admet-2387	382	17	dunne	dunne	PROPN
admet-2387	382	18	,	,	PUNCT
admet-2387	382	19	u.a	u.a	PROPN
admet-2387	382	20	.	.	PROPN
admet-2387	382	21	argikar	argikar	NOUN
admet-2387	382	22	.	.	PUNCT
admet-2387	383	1	in	in	ADP
admet-2387	383	2	vitro	vitro	X
admet-2387	383	3	ocular	ocular	ADJ
admet-2387	383	4	metabolism	metabolism	NOUN
admet-2387	383	5	and	and	CCONJ
admet-2387	383	6	bioactivation	bioactivation	NOUN
admet-2387	383	7	of	of	ADP
admet-2387	383	8	ketoconazole	ketoconazole	NOUN
admet-2387	383	9	in	in	ADP
admet-2387	383	10	rat	rat	NOUN
admet-2387	383	11	,	,	PUNCT
admet-2387	383	12	rabbit	rabbit	NOUN
admet-2387	383	13	and	and	CCONJ
admet-2387	383	14	human	human	NOUN
admet-2387	383	15	.	.	PUNCT
admet-2387	383	16	drug	drug	NOUN
admet-2387	383	17	metabolism	metabolism	NOUN
admet-2387	383	18	and	and	CCONJ
admet-2387	383	19	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	383	20	32	32	NUM
admet-2387	383	21	(	(	PUNCT
admet-2387	383	22	2017	2017	NUM
admet-2387	383	23	)	)	PUNCT
admet-2387	383	24	121	121	NUM
admet-2387	383	25	-	-	SYM
admet-2387	383	26	126	126	NUM
admet-2387	383	27	.	.	PUNCT
admet-2387	384	1	http://doi.org/10.1016/j.dmpk.2016.11.001	http://doi.org/10.1016/j.dmpk.2016.11.001	NOUN
admet-2387	384	2	.	.	PUNCT
admet-2387	385	1	[	[	X
admet-2387	385	2	56	56	NUM
admet-2387	385	3	]	]	X
admet-2387	385	4	w.	w.	PROPN
admet-2387	385	5	fitch	fitch	PROPN
admet-2387	385	6	,	,	PUNCT
admet-2387	385	7	t.	t.	PROPN
admet-2387	385	8	tran	tran	PROPN
admet-2387	385	9	,	,	PUNCT
admet-2387	385	10	m.	m.	NOUN
admet-2387	385	11	young	young	PROPN
admet-2387	385	12	,	,	PUNCT
admet-2387	385	13	l.	l.	PROPN
admet-2387	385	14	liu	liu	PROPN
admet-2387	385	15	,	,	PUNCT
admet-2387	385	16	y.	y.	PROPN
admet-2387	385	17	chen	chen	PROPN
admet-2387	385	18	.	.	PUNCT
admet-2387	386	1	revisiting	revisit	VERB
admet-2387	386	2	the	the	DET
admet-2387	386	3	metabolism	metabolism	NOUN
admet-2387	386	4	of	of	ADP
admet-2387	386	5	ketoconazole	ketoconazole	NOUN
admet-2387	386	6	using	use	VERB
admet-2387	386	7	accurate	accurate	ADJ
admet-2387	386	8	mass	mass	PROPN
admet-2387	386	9	.	.	PUNCT
admet-2387	387	1	drug	drug	NOUN
admet-2387	387	2	metabolism	metabolism	NOUN
admet-2387	387	3	letters	letter	NOUN
admet-2387	387	4	3	3	NUM
admet-2387	387	5	(	(	PUNCT
admet-2387	387	6	2009	2009	NUM
admet-2387	387	7	)	)	PUNCT
admet-2387	387	8	191	191	NUM
admet-2387	387	9	-	-	SYM
admet-2387	387	10	198	198	NUM
admet-2387	387	11	.	.	PUNCT
admet-2387	388	1	https://doi.org/10.2174/187231209789352085	https://doi.org/10.2174/187231209789352085	X
admet-2387	388	2	.	.	PUNCT
admet-2387	389	1	[	[	X
admet-2387	389	2	57	57	NUM
admet-2387	389	3	]	]	PUNCT
admet-2387	389	4	l.	l.	PROPN
admet-2387	389	5	shen	shen	PROPN
admet-2387	389	6	,	,	PUNCT
admet-2387	389	7	j.	j.	PROPN
admet-2387	389	8	wang	wang	PROPN
admet-2387	389	9	,	,	PUNCT
admet-2387	389	10	y.	y.	PROPN
admet-2387	389	11	yi	yi	PROPN
admet-2387	389	12	,	,	PUNCT
admet-2387	389	13	c.	c.	PROPN
admet-2387	389	14	ye	ye	PROPN
admet-2387	389	15	,	,	PUNCT
admet-2387	389	16	r.	r.	PROPN
admet-2387	389	17	wang	wang	PROPN
admet-2387	389	18	,	,	PUNCT
admet-2387	389	19	g.	g.	PROPN
admet-2387	389	20	xia	xia	PROPN
admet-2387	389	21	,	,	PUNCT
admet-2387	389	22	c.	c.	PROPN
admet-2387	389	23	yu	yu	PROPN
admet-2387	389	24	,	,	PUNCT
admet-2387	389	25	f.	f.	PROPN
admet-2387	389	26	tu	tu	PROPN
admet-2387	389	27	,	,	PUNCT
admet-2387	389	28	j.	j.	PROPN
admet-2387	389	29	xu	xu	PROPN
admet-2387	389	30	,	,	PUNCT
admet-2387	389	31	z.	z.	PROPN
admet-2387	389	32	zheng	zheng	PROPN
admet-2387	389	33	.	.	PUNCT
admet-2387	389	34	inhibitory	inhibitory	ADJ
admet-2387	389	35	effect	effect	NOUN
admet-2387	389	36	of	of	ADP
admet-2387	389	37	isavuconazole	isavuconazole	PROPN
admet-2387	389	38	,	,	PUNCT
admet-2387	389	39	ketoconazole	ketoconazole	NOUN
admet-2387	389	40	,	,	PUNCT
admet-2387	389	41	and	and	CCONJ
admet-2387	389	42	voriconazole	voriconazole	NOUN
admet-2387	389	43	on	on	ADP
admet-2387	389	44	the	the	DET
admet-2387	389	45	pharmacokinetics	pharmacokinetic	NOUN
admet-2387	389	46	of	of	ADP
admet-2387	389	47	methadone	methadone	NOUN
admet-2387	389	48	in	in	ADP
admet-2387	389	49	vivo	vivo	NOUN
admet-2387	389	50	and	and	CCONJ
admet-2387	389	51	in	in	ADP
admet-2387	389	52	vitro	vitro	X
admet-2387	389	53	.	.	PUNCT
admet-2387	389	54	drug	drug	NOUN
admet-2387	389	55	testing	testing	NOUN
admet-2387	389	56	and	and	CCONJ
admet-2387	389	57	analysis	analysis	NOUN
admet-2387	389	58	11	11	NUM
admet-2387	389	59	(	(	PUNCT
admet-2387	389	60	2019	2019	NUM
admet-2387	389	61	)	)	PUNCT
admet-2387	389	62	595	595	NUM
admet-2387	389	63	-	-	SYM
admet-2387	389	64	600	600	NUM
admet-2387	389	65	.	.	PUNCT
admet-2387	390	1	http://doi.org/10.1002/dta.2534	http://doi.org/10.1002/dta.2534	VERB
admet-2387	390	2	.	.	PUNCT
admet-2387	391	1	[	[	X
admet-2387	391	2	58	58	NUM
admet-2387	391	3	]	]	X
admet-2387	391	4	j.h	j.h	PROPN
admet-2387	391	5	.	.	PROPN
admet-2387	391	6	kim	kim	PROPN
admet-2387	391	7	,	,	PUNCT
admet-2387	391	8	w.g	w.g	PROPN
admet-2387	391	9	.	.	PROPN
admet-2387	391	10	choi	choi	PROPN
admet-2387	391	11	,	,	PUNCT
admet-2387	391	12	s.	s.	PROPN
admet-2387	391	13	lee	lee	PROPN
admet-2387	391	14	,	,	PUNCT
admet-2387	391	15	h.s	h.s	PROPN
admet-2387	391	16	.	.	PROPN
admet-2387	391	17	lee	lee	PROPN
admet-2387	391	18	.	.	PUNCT
admet-2387	392	1	revisiting	revisit	VERB
admet-2387	392	2	the	the	DET
admet-2387	392	3	metabolism	metabolism	NOUN
admet-2387	392	4	and	and	CCONJ
admet-2387	392	5	bioactivation	bioactivation	NOUN
admet-2387	392	6	of	of	ADP
admet-2387	392	7	ketoconazole	ketoconazole	NOUN
admet-2387	392	8	in	in	ADP
admet-2387	392	9	human	human	NOUN
admet-2387	392	10	and	and	CCONJ
admet-2387	392	11	mouse	mouse	NOUN
admet-2387	392	12	using	use	VERB
admet-2387	392	13	liquid	liquid	ADJ
admet-2387	392	14	chromatography	chromatography	NOUN
admet-2387	392	15	-	-	PUNCT
admet-2387	392	16	mass	mass	NOUN
admet-2387	392	17	spectrometry	spectrometry	NOUN
admet-2387	392	18	-	-	PUNCT
admet-2387	392	19	based	base	VERB
admet-2387	392	20	metabolomics	metabolomic	NOUN
admet-2387	392	21	.	.	PUNCT
admet-2387	393	1	international	international	ADJ
admet-2387	393	2	journal	journal	NOUN
admet-2387	393	3	of	of	ADP
admet-2387	393	4	molecular	molecular	ADJ
admet-2387	393	5	sciences	science	NOUN
admet-2387	393	6	18	18	NUM
admet-2387	393	7	(	(	PUNCT
admet-2387	393	8	2017	2017	NUM
admet-2387	393	9	)	)	PUNCT
admet-2387	393	10	621	621	NUM
admet-2387	393	11	.	.	PUNCT
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admet-2387	394	2	.	.	PUNCT
admet-2387	395	1	©	©	PROPN
admet-2387	395	2	2024	2024	NUM
admet-2387	395	3	by	by	ADP
admet-2387	395	4	the	the	DET
admet-2387	395	5	authors	author	NOUN
admet-2387	395	6	;	;	PUNCT
admet-2387	395	7	licensee	licensee	PROPN
admet-2387	395	8	iapc	iapc	PROPN
admet-2387	395	9	,	,	PUNCT
admet-2387	395	10	zagreb	zagreb	PROPN
admet-2387	395	11	,	,	PUNCT
admet-2387	395	12	croatia	croatia	PROPN
admet-2387	395	13	.	.	PUNCT
admet-2387	396	1	this	this	DET
admet-2387	396	2	article	article	NOUN
admet-2387	396	3	is	be	AUX
admet-2387	396	4	an	an	DET
admet-2387	396	5	open	open	ADJ
admet-2387	396	6	-	-	PUNCT
admet-2387	396	7	access	access	NOUN
admet-2387	396	8	article	article	NOUN
admet-2387	396	9	distributed	distribute	VERB
admet-2387	396	10	under	under	ADP
admet-2387	396	11	the	the	DET
admet-2387	396	12	terms	term	NOUN
admet-2387	396	13	and	and	CCONJ
admet-2387	396	14	conditions	condition	NOUN
admet-2387	396	15	of	of	ADP
admet-2387	396	16	the	the	DET
admet-2387	396	17	creative	creative	ADJ
admet-2387	396	18	commons	common	NOUN
admet-2387	396	19	attribution	attribution	NOUN
admet-2387	396	20	license	license	NOUN
admet-2387	396	21	(	(	PUNCT
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admet-2387	396	23	)	)	PUNCT
admet-2387	396	24	https://doi.org/10.5599/admet.2461	https://doi.org/10.5599/admet.2461	ADJ
admet-2387	396	25	http://doi.org/10.1124/jpet.102.035972	http://doi.org/10.1124/jpet.102.035972	PROPN
admet-2387	396	26	http://doi.org/10.1191/0960327104ht415oa	http://doi.org/10.1191/0960327104ht415oa	PROPN
admet-2387	396	27	http://doi.org/10.1002/biof.5520310107	http://doi.org/10.1002/biof.5520310107	NOUN
admet-2387	396	28	http://doi.org/10.1002/chir.20682	http://doi.org/10.1002/chir.20682	NOUN
admet-2387	396	29	http://doi.org/10.1007/s11655-014-1710-0	http://doi.org/10.1007/s11655-014-1710-0	NUM
admet-2387	396	30	http://doi.org/10.1007/s11655-014-1710-0	http://doi.org/10.1007/s11655-014-1710-0	NUM
admet-2387	396	31	http://doi.org/10.3109/03639045.2014.983930	http://doi.org/10.3109/03639045.2014.983930	PUNCT
admet-2387	397	1	http://doi.org/10.1124/dmd.115.063370	http://doi.org/10.1124/dmd.115.063370	INTJ
admet-2387	397	2	http://doi.org/10.1093/chromsci/bmv146	http://doi.org/10.1093/chromsci/bmv146	NOUN
admet-2387	397	3	http://doi.org/10.1016/j.jep.2022.116005	http://doi.org/10.1016/j.jep.2022.116005	PROPN
admet-2387	398	1	http://doi.org/10.1016/j.dmpk.2016.11.001	http://doi.org/10.1016/j.dmpk.2016.11.001	PROPN
admet-2387	398	2	https://doi.org/10.2174/187231209789352085	https://doi.org/10.2174/187231209789352085	NOUN
admet-2387	398	3	http://doi.org/10.1002/dta.2534	http://doi.org/10.1002/dta.2534	VERB
admet-2387	398	4	http://doi.org/10.3390/ijms18030621	http://doi.org/10.3390/ijms18030621	PROPN
admet-2387	398	5	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN