id	sid	tid	token	lemma	pos
admet-2403	1	1	ex	ex	PRON
admet-2403	1	2	vivo	vivo	ADJ
admet-2403	1	3	propofol	propofol	NOUN
admet-2403	1	4	permeation	permeation	NOUN
admet-2403	1	5	across	across	ADP
admet-2403	1	6	nasal	nasal	PROPN
admet-2403	1	7	mucosa	mucosa	PROPN
admet-2403	1	8	:	:	PUNCT
admet-2403	1	9	a	a	DET
admet-2403	1	10	proof	proof	NOUN
admet-2403	1	11	-	-	PUNCT
admet-2403	1	12	of	of	ADP
admet-2403	1	13	-	-	PUNCT
admet-2403	1	14	concept	concept	NOUN
admet-2403	1	15	study	study	NOUN
admet-2403	1	16	for	for	ADP
admet-2403	1	17	outpatient	outpatient	NOUN
admet-2403	1	18	light	light	ADJ
admet-2403	1	19	sedation	sedation	NOUN
admet-2403	1	20	via	via	ADP
admet-2403	1	21	nasal	nasal	PROPN
admet-2403	1	22	route	route	PROPN
admet-2403	1	23	doi	doi	PROPN
admet-2403	1	24	:	:	PUNCT
admet-2403	1	25	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	1	26	759	759	NUM
admet-2403	1	27	admet	admet	NOUN
admet-2403	1	28	&	&	CCONJ
admet-2403	1	29	dmpk	dmpk	PROPN
admet-2403	1	30	12(5	12(5	NUM
admet-2403	1	31	)	)	PUNCT
admet-2403	1	32	(	(	PUNCT
admet-2403	1	33	2024	2024	NUM
admet-2403	1	34	)	)	PUNCT
admet-2403	1	35	759	759	NUM
admet-2403	1	36	-	-	SYM
admet-2403	1	37	768	768	NUM
admet-2403	1	38	;	;	PUNCT
admet-2403	1	39	doi	doi	NOUN
admet-2403	1	40	:	:	PUNCT
admet-2403	1	41	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	1	42	open	open	VERB
admet-2403	1	43	access	access	NOUN
admet-2403	1	44	:	:	PUNCT
admet-2403	1	45	issn	issn	PROPN
admet-2403	1	46	:	:	PUNCT
admet-2403	1	47	1848	1848	NUM
admet-2403	1	48	-	-	SYM
admet-2403	1	49	7718	7718	NUM
admet-2403	1	50	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2403	1	51	original	original	ADJ
admet-2403	1	52	scientific	scientific	ADJ
admet-2403	1	53	paper	paper	NOUN
admet-2403	1	54	ex	ex	PRON
admet-2403	1	55	vivo	vivo	ADJ
admet-2403	1	56	propofol	propofol	NOUN
admet-2403	1	57	permeation	permeation	NOUN
admet-2403	1	58	across	across	ADP
admet-2403	1	59	nasal	nasal	PROPN
admet-2403	1	60	mucosa	mucosa	PROPN
admet-2403	1	61	:	:	PUNCT
admet-2403	1	62	a	a	DET
admet-2403	1	63	proof	proof	ADJ
admet-2403	1	64	-	-	PUNCT
admet-2403	1	65	ofconcept	ofconcept	ADJ
admet-2403	1	66	study	study	NOUN
admet-2403	1	67	for	for	ADP
admet-2403	1	68	outpatient	outpatient	NOUN
admet-2403	1	69	light	light	ADJ
admet-2403	1	70	sedation	sedation	NOUN
admet-2403	1	71	via	via	ADP
admet-2403	1	72	nasal	nasal	PROPN
admet-2403	1	73	route	route	PROPN
admet-2403	1	74	michele	michele	PROPN
admet-2403	1	75	d.	d.	PROPN
admet-2403	1	76	spampinato1	spampinato1	PROPN
admet-2403	1	77	,	,	PUNCT
admet-2403	1	78	anna	anna	PROPN
admet-2403	1	79	costanzini1	costanzini1	PROPN
admet-2403	1	80	,	,	PUNCT
admet-2403	1	81	roberto	roberto	PROPN
admet-2403	1	82	de	de	PROPN
admet-2403	1	83	giorgio1	giorgio1	PROPN
admet-2403	1	84	,	,	PUNCT
admet-2403	1	85	angelina	angelina	PROPN
admet-2403	1	86	passaro1	passaro1	PROPN
admet-2403	1	87	,	,	PUNCT
admet-2403	1	88	nicola	nicola	PROPN
admet-2403	1	89	realdon2	realdon2	PROPN
admet-2403	1	90	,	,	PUNCT
admet-2403	1	91	fabrizio	fabrizio	PROPN
admet-2403	1	92	bortolotti3	bortolotti3	NOUN
admet-2403	1	93	,	,	PUNCT
admet-2403	1	94	sabrina	sabrina	PROPN
admet-2403	1	95	banella3	banella3	PROPN
admet-2403	1	96	,	,	PUNCT
admet-2403	1	97	*	*	PROPN
admet-2403	1	98	,	,	PUNCT
admet-2403	1	99	gaia	gaia	PROPN
admet-2403	1	100	colombo3	colombo3	PROPN
admet-2403	2	1	1department	1department	NUM
admet-2403	2	2	of	of	ADP
admet-2403	2	3	translational	translational	ADJ
admet-2403	2	4	medicine	medicine	NOUN
admet-2403	2	5	,	,	PUNCT
admet-2403	2	6	st	st	PROPN
admet-2403	2	7	.	.	PROPN
admet-2403	2	8	anna	anna	PROPN
admet-2403	2	9	university	university	PROPN
admet-2403	2	10	hospital	hospital	NOUN
admet-2403	2	11	,	,	PUNCT
admet-2403	2	12	university	university	NOUN
admet-2403	2	13	of	of	ADP
admet-2403	2	14	ferrara	ferrara	NOUN
admet-2403	2	15	,	,	PUNCT
admet-2403	2	16	44124	44124	NUM
admet-2403	2	17	ferrara	ferrara	NOUN
admet-2403	2	18	,	,	PUNCT
admet-2403	2	19	italy	italy	PROPN
admet-2403	3	1	2department	2department	NUM
admet-2403	3	2	of	of	ADP
admet-2403	3	3	pharmaceutical	pharmaceutical	ADJ
admet-2403	3	4	and	and	CCONJ
admet-2403	3	5	pharmacological	pharmacological	ADJ
admet-2403	3	6	sciences	science	NOUN
admet-2403	3	7	,	,	PUNCT
admet-2403	3	8	university	university	NOUN
admet-2403	3	9	of	of	ADP
admet-2403	3	10	padova	padova	PROPN
admet-2403	3	11	,	,	PUNCT
admet-2403	3	12	35131	35131	NUM
admet-2403	3	13	padova	padova	PROPN
admet-2403	3	14	,	,	PUNCT
admet-2403	3	15	italy	italy	PROPN
admet-2403	3	16	3department	3department	NUM
admet-2403	3	17	of	of	ADP
admet-2403	3	18	life	life	NOUN
admet-2403	3	19	sciences	science	NOUN
admet-2403	3	20	and	and	CCONJ
admet-2403	3	21	biotechnology	biotechnology	NOUN
admet-2403	3	22	,	,	PUNCT
admet-2403	3	23	university	university	NOUN
admet-2403	3	24	of	of	ADP
admet-2403	3	25	ferrara	ferrara	NOUN
admet-2403	3	26	,	,	PUNCT
admet-2403	3	27	via	via	ADP
admet-2403	3	28	fossato	fossato	PROPN
admet-2403	3	29	di	di	PROPN
admet-2403	3	30	mortara	mortara	PROPN
admet-2403	3	31	19	19	NUM
admet-2403	3	32	,	,	PUNCT
admet-2403	3	33	44121	44121	NUM
admet-2403	3	34	ferrara	ferrara	NOUN
admet-2403	3	35	,	,	PUNCT
admet-2403	3	36	italy	italy	PROPN
admet-2403	3	37	*	*	PUNCT
admet-2403	3	38	corresponding	correspond	VERB
admet-2403	3	39	author	author	NOUN
admet-2403	3	40	:	:	PUNCT
admet-2403	3	41	e	e	NOUN
admet-2403	3	42	-	-	NOUN
admet-2403	3	43	mail	mail	NOUN
admet-2403	3	44	:	:	PUNCT
admet-2403	3	45	bnlsrn@unife.it	bnlsrn@unife.it	NOUN
admet-2403	3	46	;	;	PUNCT
admet-2403	3	47	tel	tel	PROPN
admet-2403	3	48	.	.	PUNCT
admet-2403	3	49	:	:	PUNCT
admet-2403	4	1	+39	+39	NOUN
admet-2403	4	2	0532	0532	NUM
admet-2403	4	3	455909	455909	NUM
admet-2403	4	4	received	receive	VERB
admet-2403	4	5	:	:	PUNCT
admet-2403	4	6	june	june	PROPN
admet-2403	4	7	16	16	NUM
admet-2403	4	8	,	,	PUNCT
admet-2403	4	9	2024	2024	NUM
admet-2403	4	10	;	;	PUNCT
admet-2403	4	11	revised	revise	VERB
admet-2403	4	12	:	:	PUNCT
admet-2403	4	13	august	august	PROPN
admet-2403	4	14	12	12	NUM
admet-2403	4	15	,	,	PUNCT
admet-2403	4	16	2024	2024	NUM
admet-2403	4	17	;	;	PUNCT
admet-2403	4	18	published	publish	VERB
admet-2403	4	19	:	:	PUNCT
admet-2403	4	20	august	august	PROPN
admet-2403	4	21	16	16	NUM
admet-2403	4	22	,	,	PUNCT
admet-2403	4	23	2024	2024	NUM
admet-2403	4	24	abstract	abstract	ADJ
admet-2403	4	25	background	background	NOUN
admet-2403	4	26	and	and	CCONJ
admet-2403	4	27	purpose	purpose	NOUN
admet-2403	4	28	:	:	PUNCT
admet-2403	4	29	aiming	aim	VERB
admet-2403	4	30	to	to	PART
admet-2403	4	31	achieve	achieve	VERB
admet-2403	4	32	light	light	ADJ
admet-2403	4	33	sedation	sedation	NOUN
admet-2403	4	34	via	via	ADP
admet-2403	4	35	intranasal	intranasal	ADJ
admet-2403	4	36	administration	administration	NOUN
admet-2403	4	37	,	,	PUNCT
admet-2403	4	38	this	this	DET
admet-2403	4	39	study	study	NOUN
admet-2403	4	40	showed	show	VERB
admet-2403	4	41	that	that	SCONJ
admet-2403	4	42	propofol	propofol	NOUN
admet-2403	4	43	(	(	PUNCT
admet-2403	4	44	ppf	ppf	PROPN
admet-2403	4	45	)	)	PUNCT
admet-2403	4	46	did	do	AUX
admet-2403	4	47	not	not	PART
admet-2403	4	48	permeate	permeate	VERB
admet-2403	4	49	across	across	ADP
admet-2403	4	50	the	the	DET
admet-2403	4	51	rabbit	rabbit	NOUN
admet-2403	4	52	nasal	nasal	PROPN
admet-2403	4	53	mucosa	mucosa	PROPN
admet-2403	4	54	ex	ex	PUNCT
admet-2403	4	55	vivo	vivo	NOUN
admet-2403	4	56	from	from	ADP
admet-2403	4	57	its	its	PRON
admet-2403	4	58	marketed	market	VERB
admet-2403	4	59	emulsion	emulsion	NOUN
admet-2403	4	60	for	for	ADP
admet-2403	4	61	injection	injection	NOUN
admet-2403	4	62	.	.	PUNCT
admet-2403	5	1	experimental	experimental	ADJ
admet-2403	5	2	approach	approach	NOUN
admet-2403	5	3	:	:	PUNCT
admet-2403	5	4	dilution	dilution	NOUN
admet-2403	5	5	of	of	ADP
admet-2403	5	6	the	the	DET
admet-2403	5	7	emulsion	emulsion	NOUN
admet-2403	5	8	with	with	ADP
admet-2403	5	9	methyl--cyclodextrin	methyl--cyclodextrin	NOUN
admet-2403	5	10	in	in	ADP
admet-2403	5	11	saline	saline	ADJ
admet-2403	5	12	solution	solution	NOUN
admet-2403	5	13	increased	increase	VERB
admet-2403	5	14	propofol	propofol	NOUN
admet-2403	5	15	solubility	solubility	NOUN
admet-2403	5	16	in	in	ADP
admet-2403	5	17	water	water	NOUN
admet-2403	5	18	and	and	CCONJ
admet-2403	5	19	diffusion	diffusion	NOUN
admet-2403	5	20	across	across	ADP
admet-2403	5	21	the	the	DET
admet-2403	5	22	nasal	nasal	PROPN
admet-2403	5	23	epithelium	epithelium	NOUN
admet-2403	5	24	.	.	PUNCT
admet-2403	6	1	key	key	ADJ
admet-2403	6	2	results	result	NOUN
admet-2403	6	3	and	and	CCONJ
admet-2403	6	4	conclusion	conclusion	NOUN
admet-2403	6	5	:	:	PUNCT
admet-2403	6	6	despite	despite	SCONJ
admet-2403	6	7	these	these	DET
admet-2403	6	8	positive	positive	ADJ
admet-2403	6	9	effects	effect	NOUN
admet-2403	6	10	of	of	ADP
admet-2403	6	11	the	the	DET
admet-2403	6	12	cyclodextrin	cyclodextrin	NOUN
admet-2403	6	13	,	,	PUNCT
admet-2403	6	14	the	the	DET
admet-2403	6	15	amount	amount	NOUN
admet-2403	6	16	of	of	ADP
admet-2403	6	17	ppf	ppf	PROPN
admet-2403	6	18	permeated	permeate	VERB
admet-2403	6	19	was	be	AUX
admet-2403	6	20	minimal	minimal	ADJ
admet-2403	6	21	in	in	ADP
admet-2403	6	22	3	3	NUM
admet-2403	6	23	h	h	NOUN
admet-2403	6	24	,	,	PUNCT
admet-2403	6	25	exceeding	exceed	VERB
admet-2403	6	26	the	the	DET
admet-2403	6	27	formulation	formulation	NOUN
admet-2403	6	28	residence	residence	NOUN
admet-2403	6	29	time	time	NOUN
admet-2403	6	30	in	in	ADP
admet-2403	6	31	the	the	DET
admet-2403	6	32	nose	nose	NOUN
admet-2403	6	33	.	.	PUNCT
admet-2403	7	1	these	these	DET
admet-2403	7	2	results	result	NOUN
admet-2403	7	3	highlight	highlight	VERB
admet-2403	7	4	the	the	DET
admet-2403	7	5	key	key	ADJ
admet-2403	7	6	role	role	NOUN
admet-2403	7	7	of	of	ADP
admet-2403	7	8	formulation	formulation	NOUN
admet-2403	7	9	and	and	CCONJ
admet-2403	7	10	the	the	DET
admet-2403	7	11	need	need	NOUN
admet-2403	7	12	for	for	ADP
admet-2403	7	13	innovation	innovation	NOUN
admet-2403	7	14	in	in	ADP
admet-2403	7	15	solubility	solubility	NOUN
admet-2403	7	16	and	and	CCONJ
admet-2403	7	17	transmucosal	transmucosal	NOUN
admet-2403	7	18	transport	transport	NOUN
admet-2403	7	19	enhancement	enhancement	NOUN
admet-2403	7	20	techniques	technique	NOUN
admet-2403	7	21	to	to	PART
admet-2403	7	22	optimize	optimize	VERB
admet-2403	7	23	drug	drug	NOUN
admet-2403	7	24	delivery	delivery	NOUN
admet-2403	7	25	and	and	CCONJ
admet-2403	7	26	therapeutic	therapeutic	ADJ
admet-2403	7	27	efficacy	efficacy	NOUN
admet-2403	7	28	.	.	PUNCT
admet-2403	8	1	©	©	ADP
admet-2403	8	2	2024	2024	NUM
admet-2403	8	3	by	by	ADP
admet-2403	8	4	the	the	DET
admet-2403	8	5	authors	author	NOUN
admet-2403	8	6	.	.	PUNCT
admet-2403	9	1	this	this	DET
admet-2403	9	2	article	article	NOUN
admet-2403	9	3	is	be	AUX
admet-2403	9	4	an	an	DET
admet-2403	9	5	open	open	ADJ
admet-2403	9	6	-	-	PUNCT
admet-2403	9	7	access	access	NOUN
admet-2403	9	8	article	article	NOUN
admet-2403	9	9	distributed	distribute	VERB
admet-2403	9	10	under	under	ADP
admet-2403	9	11	the	the	DET
admet-2403	9	12	terms	term	NOUN
admet-2403	9	13	and	and	CCONJ
admet-2403	9	14	conditions	condition	NOUN
admet-2403	9	15	of	of	ADP
admet-2403	9	16	the	the	DET
admet-2403	9	17	creative	creative	ADJ
admet-2403	9	18	commons	common	NOUN
admet-2403	9	19	attribution	attribution	NOUN
admet-2403	9	20	license	license	NOUN
admet-2403	9	21	(	(	PUNCT
admet-2403	9	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2403	9	23	)	)	PUNCT
admet-2403	9	24	.	.	PUNCT
admet-2403	10	1	keywords	keyword	VERB
admet-2403	10	2	sedative	sedative	ADJ
admet-2403	10	3	drug	drug	NOUN
admet-2403	10	4	;	;	PUNCT
admet-2403	10	5	nasal	nasal	PROPN
admet-2403	10	6	administration	administration	NOUN
admet-2403	10	7	;	;	PUNCT
admet-2403	10	8	aqueous	aqueous	ADJ
admet-2403	10	9	solubility	solubility	NOUN
admet-2403	10	10	;	;	PUNCT
admet-2403	10	11	-cyclodextrin	-cyclodextrin	PROPN
admet-2403	10	12	;	;	PUNCT
admet-2403	10	13	transmucosal	transmucosal	PROPN
admet-2403	10	14	permeation	permeation	NOUN
admet-2403	10	15	.	.	PUNCT
admet-2403	11	1	introduction	introduction	NOUN
admet-2403	11	2	propofol	propofol	NOUN
admet-2403	11	3	(	(	PUNCT
admet-2403	11	4	ppf	ppf	PROPN
admet-2403	11	5	)	)	PUNCT
admet-2403	11	6	is	be	AUX
admet-2403	11	7	an	an	DET
admet-2403	11	8	intravenous	intravenous	ADJ
admet-2403	11	9	anesthetic	anesthetic	NOUN
admet-2403	11	10	and	and	CCONJ
admet-2403	11	11	sedative	sedative	ADJ
admet-2403	11	12	drug	drug	NOUN
admet-2403	11	13	extensively	extensively	ADV
admet-2403	11	14	used	use	VERB
admet-2403	11	15	in	in	ADP
admet-2403	11	16	clinical	clinical	ADJ
admet-2403	11	17	practice	practice	NOUN
admet-2403	11	18	.	.	PUNCT
admet-2403	12	1	it	it	PRON
admet-2403	12	2	is	be	AUX
admet-2403	12	3	administered	administer	VERB
admet-2403	12	4	intravenously	intravenously	ADV
admet-2403	12	5	(	(	PUNCT
admet-2403	12	6	iv	iv	X
admet-2403	12	7	)	)	PUNCT
admet-2403	12	8	as	as	ADP
admet-2403	12	9	a	a	DET
admet-2403	12	10	bolus	bolus	ADJ
admet-2403	12	11	injection	injection	NOUN
admet-2403	12	12	or	or	CCONJ
admet-2403	12	13	infusion	infusion	NOUN
admet-2403	12	14	[	[	X
admet-2403	12	15	1	1	NUM
admet-2403	12	16	]	]	PUNCT
admet-2403	12	17	.	.	PUNCT
admet-2403	13	1	it	it	PRON
admet-2403	13	2	also	also	ADV
admet-2403	13	3	exhibits	exhibit	VERB
admet-2403	13	4	dose	dose	NOUN
admet-2403	13	5	-	-	PUNCT
admet-2403	13	6	dependent	dependent	ADJ
admet-2403	13	7	amnestic	amnestic	ADJ
admet-2403	13	8	and	and	CCONJ
admet-2403	13	9	anxiolytic	anxiolytic	ADJ
admet-2403	13	10	effects	effect	NOUN
admet-2403	13	11	[	[	X
admet-2403	13	12	2	2	NUM
admet-2403	13	13	]	]	PUNCT
admet-2403	13	14	.	.	PUNCT
admet-2403	14	1	procedural	procedural	ADJ
admet-2403	14	2	sedation	sedation	NOUN
admet-2403	14	3	and	and	CCONJ
admet-2403	14	4	analgesia	analgesia	NOUN
admet-2403	14	5	are	be	AUX
admet-2403	14	6	of	of	ADP
admet-2403	14	7	utmost	utmost	ADJ
admet-2403	14	8	importance	importance	NOUN
admet-2403	14	9	in	in	ADP
admet-2403	14	10	emergency	emergency	NOUN
admet-2403	14	11	medicine	medicine	NOUN
admet-2403	14	12	,	,	PUNCT
admet-2403	14	13	both	both	CCONJ
admet-2403	14	14	in	in	ADP
admet-2403	14	15	the	the	DET
admet-2403	14	16	prehospital	prehospital	NOUN
admet-2403	14	17	and	and	CCONJ
admet-2403	14	18	hospital	hospital	NOUN
admet-2403	14	19	settings	setting	NOUN
admet-2403	14	20	[	[	X
admet-2403	14	21	3	3	NUM
admet-2403	14	22	]	]	PUNCT
admet-2403	14	23	.	.	PUNCT
admet-2403	15	1	despite	despite	SCONJ
admet-2403	15	2	pain	pain	NOUN
admet-2403	15	3	being	be	AUX
admet-2403	15	4	one	one	NUM
admet-2403	15	5	of	of	ADP
admet-2403	15	6	the	the	DET
admet-2403	15	7	primary	primary	ADJ
admet-2403	15	8	reasons	reason	NOUN
admet-2403	15	9	for	for	ADP
admet-2403	15	10	access	access	NOUN
admet-2403	15	11	to	to	ADP
admet-2403	15	12	the	the	DET
admet-2403	15	13	emergency	emergency	NOUN
admet-2403	15	14	department	department	NOUN
admet-2403	15	15	(	(	PUNCT
admet-2403	15	16	ed	ed	NOUN
admet-2403	15	17	)	)	PUNCT
admet-2403	15	18	[	[	X
admet-2403	15	19	4	4	NUM
admet-2403	15	20	]	]	PUNCT
admet-2403	15	21	,	,	PUNCT
admet-2403	15	22	the	the	DET
admet-2403	15	23	control	control	NOUN
admet-2403	15	24	of	of	ADP
admet-2403	15	25	a	a	DET
admet-2403	15	26	patient	patient	NOUN
admet-2403	15	27	’s	’s	PART
admet-2403	15	28	anxiety	anxiety	NOUN
admet-2403	15	29	and	and	CCONJ
admet-2403	15	30	consciousness	consciousness	NOUN
admet-2403	15	31	is	be	AUX
admet-2403	15	32	a	a	DET
admet-2403	15	33	fundamental	fundamental	ADJ
admet-2403	15	34	skill	skill	NOUN
admet-2403	15	35	of	of	ADP
admet-2403	15	36	the	the	DET
admet-2403	15	37	emergency	emergency	NOUN
admet-2403	15	38	physician	physician	NOUN
admet-2403	16	1	[	[	X
admet-2403	16	2	5	5	NUM
admet-2403	16	3	]	]	PUNCT
admet-2403	16	4	,	,	PUNCT
admet-2403	16	5	at	at	ADP
admet-2403	16	6	any	any	DET
admet-2403	16	7	stage	stage	NOUN
admet-2403	16	8	of	of	ADP
admet-2403	16	9	life	life	NOUN
admet-2403	16	10	[	[	X
admet-2403	16	11	6	6	NUM
admet-2403	16	12	]	]	PUNCT
admet-2403	16	13	.	.	PUNCT
admet-2403	17	1	sedation	sedation	NOUN
admet-2403	17	2	eases	ease	VERB
admet-2403	17	3	diagnostic	diagnostic	ADJ
admet-2403	17	4	and	and	CCONJ
admet-2403	17	5	therapeutic	therapeutic	ADJ
admet-2403	17	6	procedures	procedure	NOUN
admet-2403	17	7	(	(	PUNCT
admet-2403	17	8	e.g.	e.g.	ADV
admet-2403	17	9	,	,	PUNCT
admet-2403	17	10	luxation	luxation	NOUN
admet-2403	17	11	reduction	reduction	NOUN
admet-2403	17	12	,	,	PUNCT
admet-2403	17	13	wound	wound	NOUN
admet-2403	17	14	exploration	exploration	NOUN
admet-2403	17	15	,	,	PUNCT
admet-2403	17	16	etc	etc	X
admet-2403	17	17	.	.	X
admet-2403	17	18	)	)	PUNCT
admet-2403	17	19	,	,	PUNCT
admet-2403	17	20	especially	especially	ADV
admet-2403	17	21	in	in	ADP
admet-2403	17	22	poorly	poorly	ADV
admet-2403	17	23	cooperative	cooperative	ADJ
admet-2403	17	24	patients	patient	NOUN
admet-2403	17	25	.	.	PUNCT
admet-2403	18	1	multiple	multiple	ADJ
admet-2403	18	2	strategies	strategy	NOUN
admet-2403	18	3	and	and	CCONJ
admet-2403	18	4	medications	medication	NOUN
admet-2403	18	5	are	be	AUX
admet-2403	18	6	available	available	ADJ
admet-2403	18	7	for	for	ADP
admet-2403	18	8	pain	pain	NOUN
admet-2403	18	9	control	control	NOUN
admet-2403	18	10	,	,	PUNCT
admet-2403	18	11	some	some	PRON
admet-2403	18	12	delivered	deliver	VERB
admet-2403	18	13	via	via	ADP
admet-2403	18	14	non	non	ADJ
admet-2403	18	15	-	-	ADJ
admet-2403	18	16	conventional	conventional	ADJ
admet-2403	18	17	drug	drug	NOUN
admet-2403	18	18	administration	administration	NOUN
admet-2403	18	19	routes	route	NOUN
admet-2403	18	20	like	like	ADP
admet-2403	18	21	the	the	DET
admet-2403	18	22	nasal	nasal	PROPN
admet-2403	18	23	one	one	NUM
admet-2403	18	24	.	.	PUNCT
admet-2403	19	1	in	in	ADP
admet-2403	19	2	contrast	contrast	NOUN
admet-2403	19	3	,	,	PUNCT
admet-2403	19	4	fewer	few	ADJ
admet-2403	19	5	options	option	NOUN
admet-2403	19	6	exist	exist	VERB
admet-2403	19	7	for	for	ADP
admet-2403	19	8	light	light	ADJ
admet-2403	19	9	sedation	sedation	NOUN
admet-2403	19	10	.	.	PUNCT
admet-2403	20	1	in	in	ADP
admet-2403	20	2	clinical	clinical	ADJ
admet-2403	20	3	practice	practice	NOUN
admet-2403	20	4	,	,	PUNCT
admet-2403	20	5	the	the	DET
admet-2403	20	6	ideal	ideal	ADJ
admet-2403	20	7	sedative	sedative	NOUN
admet-2403	20	8	should	should	AUX
admet-2403	20	9	:	:	PUNCT
admet-2403	20	10	1	1	X
admet-2403	20	11	)	)	PUNCT
admet-2403	20	12	be	be	AUX
admet-2403	20	13	rapidly	rapidly	ADV
admet-2403	20	14	administered	administer	VERB
admet-2403	20	15	;	;	PUNCT
admet-2403	20	16	2	2	X
admet-2403	20	17	)	)	PUNCT
admet-2403	20	18	show	show	VERB
admet-2403	20	19	rapid	rapid	ADJ
admet-2403	20	20	onset	onset	NOUN
admet-2403	20	21	and	and	CCONJ
admet-2403	20	22	offset	offset	NOUN
admet-2403	20	23	of	of	ADP
admet-2403	20	24	action	action	NOUN
admet-2403	20	25	,	,	PUNCT
admet-2403	20	26	possibly	possibly	ADV
admet-2403	20	27	with	with	ADP
admet-2403	20	28	a	a	DET
admet-2403	20	29	linear	linear	ADJ
admet-2403	20	30	dose	dose	NOUN
admet-2403	20	31	-	-	PUNCT
admet-2403	20	32	response	response	NOUN
admet-2403	20	33	relationship	relationship	NOUN
admet-2403	20	34	;	;	PUNCT
admet-2403	20	35	and	and	CCONJ
admet-2403	20	36	3	3	X
admet-2403	20	37	)	)	PUNCT
admet-2403	20	38	cause	cause	VERB
admet-2403	20	39	minimal	minimal	ADJ
admet-2403	20	40	and	and	CCONJ
admet-2403	20	41	predictable	predictable	ADJ
admet-2403	20	42	side	side	NOUN
admet-2403	20	43	effects	effect	NOUN
admet-2403	20	44	.	.	PUNCT
admet-2403	21	1	ppf	ppf	PROPN
admet-2403	21	2	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	21	3	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	21	4	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2403	21	5	mailto:bnlsrn@unife.it	mailto:bnlsrn@unife.it	NOUN
admet-2403	21	6	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2403	21	7	m.	m.	PROPN
admet-2403	21	8	d.	d.	PROPN
admet-2403	21	9	spampinato	spampinato	PROPN
admet-2403	21	10	et	et	PROPN
admet-2403	21	11	al	al	PROPN
admet-2403	21	12	.	.	PROPN
admet-2403	21	13	admet	admet	PROPN
admet-2403	21	14	&	&	CCONJ
admet-2403	21	15	dmpk	dmpk	PROPN
admet-2403	21	16	12(5	12(5	NUM
admet-2403	21	17	)	)	PUNCT
admet-2403	21	18	(	(	PUNCT
admet-2403	21	19	2024	2024	NUM
admet-2403	21	20	)	)	PUNCT
admet-2403	21	21	759	759	NUM
admet-2403	21	22	-	-	SYM
admet-2403	21	23	768	768	NUM
admet-2403	21	24	760	760	NUM
admet-2403	21	25	possesses	possesse	NOUN
admet-2403	21	26	all	all	DET
admet-2403	21	27	these	these	DET
admet-2403	21	28	properties	property	NOUN
admet-2403	21	29	and	and	CCONJ
admet-2403	21	30	thus	thus	ADV
admet-2403	21	31	is	be	AUX
admet-2403	21	32	widely	widely	ADV
admet-2403	21	33	used	use	VERB
admet-2403	21	34	for	for	ADP
admet-2403	21	35	anesthesia	anesthesia	NOUN
admet-2403	21	36	during	during	ADP
admet-2403	21	37	surgery	surgery	NOUN
admet-2403	21	38	.	.	PUNCT
admet-2403	22	1	its	its	PRON
admet-2403	22	2	use	use	NOUN
admet-2403	22	3	by	by	ADP
admet-2403	22	4	nonanesthesiologists	nonanesthesiologist	NOUN
admet-2403	22	5	has	have	AUX
admet-2403	22	6	been	be	AUX
admet-2403	22	7	extended	extend	VERB
admet-2403	22	8	for	for	ADP
admet-2403	22	9	sedating	sedate	VERB
admet-2403	22	10	non	non	ADJ
admet-2403	22	11	-	-	ADJ
admet-2403	22	12	surgical	surgical	ADJ
admet-2403	22	13	patients	patient	NOUN
admet-2403	22	14	[	[	X
admet-2403	22	15	7,8	7,8	NUM
admet-2403	22	16	]	]	PUNCT
admet-2403	22	17	.	.	PUNCT
admet-2403	23	1	ppf	ppf	PROPN
admet-2403	23	2	has	have	VERB
admet-2403	23	3	very	very	ADV
admet-2403	23	4	low	low	ADJ
admet-2403	23	5	solubility	solubility	NOUN
admet-2403	23	6	in	in	ADP
admet-2403	23	7	water	water	NOUN
admet-2403	23	8	,	,	PUNCT
admet-2403	23	9	as	as	SCONJ
admet-2403	23	10	reported	report	VERB
admet-2403	23	11	by	by	ADP
admet-2403	23	12	kazi	kazi	PROPN
admet-2403	23	13	et	et	PROPN
admet-2403	23	14	al	al	PROPN
admet-2403	23	15	.	.	PUNCT
admet-2403	24	1	[	[	X
admet-2403	24	2	9	9	NUM
admet-2403	24	3	]	]	PUNCT
admet-2403	24	4	and	and	CCONJ
admet-2403	24	5	date	date	NOUN
admet-2403	24	6	and	and	CCONJ
admet-2403	24	7	nagarsenken	nagarsenken	PROPN
admet-2403	24	8	[	[	X
admet-2403	24	9	10	10	NUM
admet-2403	24	10	]	]	PUNCT
admet-2403	24	11	without	without	ADP
admet-2403	24	12	specifying	specify	VERB
admet-2403	24	13	the	the	DET
admet-2403	24	14	temperature	temperature	NOUN
admet-2403	24	15	(	(	PUNCT
admet-2403	24	16	0.124	0.124	NUM
admet-2403	24	17	or	or	CCONJ
admet-2403	24	18	0.154	0.154	NUM
admet-2403	24	19	mg	mg	PROPN
admet-2403	24	20	/	/	SYM
admet-2403	24	21	ml	ml	NOUN
admet-2403	24	22	,	,	PUNCT
admet-2403	24	23	respectively	respectively	ADV
admet-2403	24	24	)	)	PUNCT
admet-2403	24	25	.	.	PUNCT
admet-2403	25	1	for	for	ADP
admet-2403	25	2	this	this	DET
admet-2403	25	3	reason	reason	NOUN
admet-2403	25	4	,	,	PUNCT
admet-2403	25	5	it	it	PRON
admet-2403	25	6	is	be	AUX
admet-2403	25	7	formulated	formulate	VERB
admet-2403	25	8	as	as	ADP
admet-2403	25	9	a	a	DET
admet-2403	25	10	lipidbased	lipidbased	ADJ
admet-2403	25	11	liquid	liquid	NOUN
admet-2403	25	12	for	for	ADP
admet-2403	25	13	injection	injection	NOUN
admet-2403	25	14	.	.	PUNCT
admet-2403	26	1	ppf	ppf	PROPN
admet-2403	26	2	raw	raw	ADJ
admet-2403	26	3	material	material	NOUN
admet-2403	26	4	itself	itself	PRON
admet-2403	26	5	is	be	AUX
admet-2403	26	6	a	a	DET
admet-2403	26	7	yellow	yellow	ADJ
admet-2403	26	8	oily	oily	ADJ
admet-2403	26	9	liquid	liquid	ADJ
admet-2403	26	10	[	[	X
admet-2403	26	11	11	11	NUM
admet-2403	26	12	]	]	PUNCT
admet-2403	26	13	.	.	PUNCT
admet-2403	27	1	the	the	DET
admet-2403	27	2	marketed	market	VERB
admet-2403	27	3	products	product	NOUN
admet-2403	27	4	are	be	AUX
admet-2403	27	5	oilin	oilin	NOUN
admet-2403	27	6	-	-	PUNCT
admet-2403	27	7	water	water	NOUN
admet-2403	27	8	emulsions	emulsion	NOUN
admet-2403	27	9	at	at	ADP
admet-2403	27	10	1	1	NUM
admet-2403	27	11	or	or	CCONJ
admet-2403	27	12	2	2	NUM
admet-2403	27	13	%	%	NOUN
admet-2403	27	14	ppf	ppf	PROPN
admet-2403	27	15	concentration	concentration	NOUN
admet-2403	27	16	(	(	PUNCT
admet-2403	27	17	e.g.	e.g.	ADV
admet-2403	27	18	,	,	PUNCT
admet-2403	27	19	diprivan	diprivan	PROPN
admet-2403	27	20	®	®	NOUN
admet-2403	27	21	by	by	ADP
admet-2403	27	22	aspen	aspen	ADJ
admet-2403	27	23	pharma	pharma	PROPN
admet-2403	27	24	or	or	CCONJ
admet-2403	27	25	the	the	DET
admet-2403	27	26	generic	generic	ADJ
admet-2403	27	27	propofol	propofol	NOUN
admet-2403	27	28	kabi	kabi	PROPN
admet-2403	27	29	in	in	ADP
admet-2403	27	30	italy	italy	PROPN
admet-2403	27	31	)	)	PUNCT
admet-2403	27	32	.	.	PUNCT
admet-2403	28	1	their	their	PRON
admet-2403	28	2	iv	iv	NUM
admet-2403	28	3	bolus	bolus	NOUN
admet-2403	28	4	causes	cause	VERB
admet-2403	28	5	injection	injection	NOUN
admet-2403	28	6	-	-	PUNCT
admet-2403	28	7	site	site	NOUN
admet-2403	28	8	pain	pain	NOUN
admet-2403	29	1	[	[	X
admet-2403	29	2	12	12	NUM
admet-2403	29	3	]	]	PUNCT
admet-2403	29	4	,	,	PUNCT
admet-2403	29	5	whose	whose	DET
admet-2403	29	6	origin	origin	NOUN
admet-2403	29	7	and	and	CCONJ
admet-2403	29	8	mechanism	mechanism	NOUN
admet-2403	29	9	remain	remain	VERB
admet-2403	29	10	unclear	unclear	ADJ
admet-2403	29	11	.	.	PUNCT
admet-2403	30	1	the	the	DET
admet-2403	30	2	drug	drug	NOUN
admet-2403	30	3	itself	itself	PRON
admet-2403	30	4	,	,	PUNCT
admet-2403	30	5	the	the	DET
admet-2403	30	6	lipid	lipid	NOUN
admet-2403	30	7	excipient	excipient	NOUN
admet-2403	30	8	,	,	PUNCT
admet-2403	30	9	and	and	CCONJ
admet-2403	30	10	the	the	DET
admet-2403	30	11	venous	venous	ADJ
admet-2403	30	12	access	access	NOUN
admet-2403	30	13	are	be	AUX
admet-2403	30	14	factors	factor	NOUN
admet-2403	30	15	possibly	possibly	ADV
admet-2403	30	16	involved	involve	VERB
admet-2403	30	17	in	in	ADP
admet-2403	30	18	the	the	DET
admet-2403	30	19	pain	pain	NOUN
admet-2403	30	20	experience	experience	NOUN
admet-2403	30	21	.	.	PUNCT
admet-2403	31	1	considering	consider	VERB
admet-2403	31	2	this	this	PRON
admet-2403	31	3	and	and	CCONJ
admet-2403	31	4	other	other	ADJ
admet-2403	31	5	drawbacks	drawback	NOUN
admet-2403	31	6	of	of	ADP
admet-2403	31	7	iv	iv	NUM
admet-2403	31	8	ppf	ppf	PROPN
admet-2403	31	9	[	[	X
admet-2403	31	10	2	2	NUM
admet-2403	31	11	]	]	PUNCT
admet-2403	31	12	,	,	PUNCT
admet-2403	31	13	a	a	DET
admet-2403	31	14	new	new	ADJ
admet-2403	31	15	concept	concept	NOUN
admet-2403	31	16	could	could	AUX
admet-2403	31	17	be	be	AUX
admet-2403	31	18	to	to	PART
admet-2403	31	19	change	change	VERB
admet-2403	31	20	the	the	DET
admet-2403	31	21	administration	administration	NOUN
admet-2403	31	22	route	route	NOUN
admet-2403	31	23	,	,	PUNCT
admet-2403	31	24	especially	especially	ADV
admet-2403	31	25	when	when	SCONJ
admet-2403	31	26	light	light	ADJ
admet-2403	31	27	sedation	sedation	NOUN
admet-2403	31	28	,	,	PUNCT
admet-2403	31	29	instead	instead	ADV
admet-2403	31	30	of	of	ADP
admet-2403	31	31	deep	deep	ADJ
admet-2403	31	32	anesthesia	anesthesia	NOUN
admet-2403	31	33	,	,	PUNCT
admet-2403	31	34	is	be	AUX
admet-2403	31	35	preferred	prefer	VERB
admet-2403	31	36	.	.	PUNCT
admet-2403	32	1	the	the	DET
admet-2403	32	2	intranasal	intranasal	NOUN
admet-2403	32	3	(	(	PUNCT
admet-2403	32	4	in	in	ADP
admet-2403	32	5	)	)	PUNCT
admet-2403	32	6	route	route	NOUN
admet-2403	32	7	is	be	AUX
admet-2403	32	8	intriguing	intriguing	ADJ
admet-2403	32	9	for	for	ADP
admet-2403	32	10	this	this	DET
admet-2403	32	11	purpose	purpose	NOUN
admet-2403	32	12	.	.	PUNCT
admet-2403	33	1	in	in	ADP
admet-2403	33	2	fact	fact	NOUN
admet-2403	33	3	,	,	PUNCT
admet-2403	33	4	several	several	ADJ
admet-2403	33	5	drug	drug	NOUN
admet-2403	33	6	substances	substance	NOUN
admet-2403	33	7	elicit	elicit	VERB
admet-2403	33	8	a	a	DET
admet-2403	33	9	systemic	systemic	ADJ
admet-2403	33	10	effect	effect	NOUN
admet-2403	33	11	upon	upon	SCONJ
admet-2403	33	12	delivery	delivery	NOUN
admet-2403	33	13	and	and	CCONJ
admet-2403	33	14	deposition	deposition	NOUN
admet-2403	33	15	of	of	ADP
admet-2403	33	16	the	the	DET
admet-2403	33	17	formulation	formulation	NOUN
admet-2403	33	18	inside	inside	ADP
admet-2403	33	19	the	the	DET
admet-2403	33	20	nasal	nasal	ADJ
admet-2403	33	21	cavities	cavity	NOUN
admet-2403	34	1	[	[	X
admet-2403	34	2	13,14	13,14	NUM
admet-2403	34	3	]	]	PUNCT
admet-2403	34	4	.	.	PUNCT
admet-2403	35	1	midazolam	midazolam	PROPN
admet-2403	35	2	and	and	CCONJ
admet-2403	35	3	fentanyl	fentanyl	NOUN
admet-2403	35	4	are	be	AUX
admet-2403	35	5	successfully	successfully	ADV
admet-2403	35	6	employed	employ	VERB
admet-2403	35	7	for	for	ADP
admet-2403	35	8	in	in	ADP
admet-2403	35	9	analgesia	analgesia	NOUN
admet-2403	35	10	and	and	CCONJ
admet-2403	35	11	sedation	sedation	NOUN
admet-2403	35	12	,	,	PUNCT
admet-2403	35	13	especially	especially	ADV
admet-2403	35	14	in	in	ADP
admet-2403	35	15	children	child	NOUN
admet-2403	35	16	[	[	X
admet-2403	35	17	15,16	15,16	NUM
admet-2403	35	18	]	]	PUNCT
admet-2403	35	19	.	.	PUNCT
admet-2403	36	1	ketamine	ketamine	PROPN
admet-2403	36	2	and	and	CCONJ
admet-2403	36	3	dexmedetomidine	dexmedetomidine	PROPN
admet-2403	36	4	,	,	PUNCT
admet-2403	36	5	even	even	ADV
admet-2403	36	6	in	in	ADP
admet-2403	36	7	association	association	NOUN
admet-2403	36	8	,	,	PUNCT
admet-2403	36	9	have	have	AUX
admet-2403	36	10	been	be	AUX
admet-2403	36	11	considered	consider	VERB
admet-2403	36	12	as	as	ADV
admet-2403	36	13	well	well	ADV
admet-2403	36	14	[	[	X
admet-2403	36	15	17,18	17,18	NUM
admet-2403	36	16	]	]	PUNCT
admet-2403	36	17	.	.	PUNCT
admet-2403	37	1	following	follow	VERB
admet-2403	37	2	in	in	ADP
admet-2403	37	3	administration	administration	NOUN
admet-2403	37	4	,	,	PUNCT
admet-2403	37	5	anxiolytic	anxiolytic	ADJ
admet-2403	37	6	and	and	CCONJ
admet-2403	37	7	sedative	sedative	ADJ
admet-2403	37	8	effects	effect	NOUN
admet-2403	37	9	may	may	AUX
admet-2403	37	10	result	result	VERB
admet-2403	37	11	from	from	ADP
admet-2403	37	12	the	the	DET
admet-2403	37	13	double	double	ADJ
admet-2403	37	14	contribution	contribution	NOUN
admet-2403	37	15	of	of	ADP
admet-2403	37	16	i	i	PROPN
admet-2403	37	17	)	)	PUNCT
admet-2403	37	18	rapid	rapid	ADJ
admet-2403	37	19	absorption	absorption	NOUN
admet-2403	37	20	of	of	ADP
admet-2403	37	21	the	the	DET
admet-2403	37	22	drug	drug	NOUN
admet-2403	37	23	across	across	ADP
admet-2403	37	24	the	the	DET
admet-2403	37	25	nasal	nasal	ADJ
admet-2403	37	26	epithelium	epithelium	NOUN
admet-2403	37	27	and	and	CCONJ
admet-2403	37	28	entry	entry	NOUN
admet-2403	37	29	into	into	ADP
admet-2403	37	30	the	the	DET
admet-2403	37	31	blood	blood	NOUN
admet-2403	37	32	circulation	circulation	NOUN
admet-2403	37	33	and	and	CCONJ
admet-2403	37	34	ii	ii	NOUN
admet-2403	37	35	)	)	PUNCT
admet-2403	37	36	direct	direct	ADJ
admet-2403	37	37	nose	nose	NOUN
admet-2403	37	38	-	-	PUNCT
admet-2403	37	39	to	to	ADP
admet-2403	37	40	-	-	PUNCT
admet-2403	37	41	brain	brain	NOUN
admet-2403	37	42	transport	transport	NOUN
admet-2403	37	43	via	via	ADP
admet-2403	37	44	the	the	DET
admet-2403	37	45	olfactory	olfactory	NOUN
admet-2403	37	46	and	and	CCONJ
admet-2403	37	47	trigeminal	trigeminal	ADJ
admet-2403	37	48	pathways	pathway	NOUN
admet-2403	38	1	[	[	X
admet-2403	38	2	19	19	NUM
admet-2403	38	3	]	]	PUNCT
admet-2403	38	4	.	.	PUNCT
admet-2403	39	1	the	the	DET
admet-2403	39	2	approach	approach	NOUN
admet-2403	39	3	is	be	AUX
admet-2403	39	4	non	non	ADJ
admet-2403	39	5	-	-	ADJ
admet-2403	39	6	invasive	invasive	ADJ
admet-2403	39	7	and	and	CCONJ
admet-2403	39	8	relevant	relevant	ADJ
admet-2403	39	9	for	for	ADP
admet-2403	39	10	uncooperative	uncooperative	ADJ
admet-2403	39	11	patients	patient	NOUN
admet-2403	39	12	.	.	PUNCT
admet-2403	40	1	it	it	PRON
admet-2403	40	2	may	may	AUX
admet-2403	40	3	also	also	ADV
admet-2403	40	4	work	work	VERB
admet-2403	40	5	for	for	ADP
admet-2403	40	6	other	other	ADJ
admet-2403	40	7	sedative	sedative	ADJ
admet-2403	40	8	and	and	CCONJ
admet-2403	40	9	anxiolytic	anxiolytic	ADJ
admet-2403	40	10	agents	agent	NOUN
admet-2403	40	11	in	in	ADP
admet-2403	40	12	the	the	DET
admet-2403	40	13	ed	ed	NOUN
admet-2403	40	14	,	,	PUNCT
admet-2403	40	15	including	include	VERB
admet-2403	40	16	propofol	propofol	NOUN
admet-2403	40	17	.	.	PUNCT
admet-2403	41	1	only	only	ADV
admet-2403	41	2	one	one	NUM
admet-2403	41	3	study	study	NOUN
admet-2403	41	4	investigated	investigate	VERB
admet-2403	41	5	the	the	DET
admet-2403	41	6	sedation	sedation	NOUN
admet-2403	41	7	effect	effect	NOUN
admet-2403	41	8	elicited	elicit	VERB
admet-2403	41	9	by	by	ADP
admet-2403	41	10	ppf	ppf	PROPN
admet-2403	41	11	emulsion	emulsion	NOUN
admet-2403	41	12	administered	administer	VERB
admet-2403	41	13	intranasally	intranasally	ADV
admet-2403	41	14	to	to	ADP
admet-2403	41	15	rats	rat	NOUN
admet-2403	41	16	[	[	X
admet-2403	41	17	20	20	NUM
admet-2403	41	18	]	]	PUNCT
admet-2403	41	19	.	.	PUNCT
admet-2403	42	1	these	these	DET
admet-2403	42	2	authors	author	NOUN
admet-2403	42	3	found	find	VERB
admet-2403	42	4	a	a	DET
admet-2403	42	5	pharmacodynamic	pharmacodynamic	ADJ
admet-2403	42	6	response	response	NOUN
admet-2403	42	7	to	to	ADP
admet-2403	42	8	in	in	ADP
admet-2403	42	9	diprivan	diprivan	PROPN
admet-2403	42	10	®	®	NOUN
admet-2403	42	11	not	not	PART
admet-2403	42	12	significantly	significantly	ADV
admet-2403	42	13	different	different	ADJ
admet-2403	42	14	from	from	ADP
admet-2403	42	15	that	that	PRON
admet-2403	42	16	of	of	ADP
admet-2403	42	17	in	in	ADP
admet-2403	42	18	saline	saline	NOUN
admet-2403	42	19	(	(	PUNCT
admet-2403	42	20	negative	negative	ADJ
admet-2403	42	21	control	control	NOUN
admet-2403	42	22	)	)	PUNCT
admet-2403	42	23	,	,	PUNCT
admet-2403	42	24	whereas	whereas	SCONJ
admet-2403	42	25	sedation	sedation	NOUN
admet-2403	42	26	was	be	AUX
admet-2403	42	27	obtained	obtain	VERB
admet-2403	42	28	with	with	ADP
admet-2403	42	29	in	in	ADP
admet-2403	42	30	propofol	propofol	NOUN
admet-2403	42	31	-	-	PUNCT
admet-2403	42	32	loaded	load	VERB
admet-2403	42	33	chitosan	chitosan	ADJ
admet-2403	42	34	amphiphilic	amphiphilic	ADJ
admet-2403	42	35	nanoparticles	nanoparticle	NOUN
admet-2403	42	36	.	.	PUNCT
admet-2403	43	1	the	the	DET
admet-2403	43	2	greater	great	ADJ
admet-2403	43	3	response	response	NOUN
admet-2403	43	4	to	to	ADP
admet-2403	43	5	the	the	DET
admet-2403	43	6	non	non	ADJ
admet-2403	43	7	-	-	ADJ
admet-2403	43	8	lipid	lipid	ADJ
admet-2403	43	9	nanoparticles	nanoparticle	NOUN
admet-2403	43	10	vs.	vs.	ADP
admet-2403	43	11	the	the	DET
admet-2403	43	12	lipid	lipid	NOUN
admet-2403	43	13	emulsion	emulsion	NOUN
admet-2403	43	14	was	be	AUX
admet-2403	43	15	attributed	attribute	VERB
admet-2403	43	16	to	to	ADP
admet-2403	43	17	an	an	DET
admet-2403	43	18	effect	effect	NOUN
admet-2403	43	19	of	of	ADP
admet-2403	43	20	the	the	DET
admet-2403	43	21	formulation	formulation	NOUN
admet-2403	43	22	.	.	PUNCT
admet-2403	44	1	here	here	ADV
admet-2403	44	2	,	,	PUNCT
admet-2403	44	3	we	we	PRON
admet-2403	44	4	assessed	assess	VERB
admet-2403	44	5	the	the	DET
admet-2403	44	6	transport	transport	NOUN
admet-2403	44	7	of	of	ADP
admet-2403	44	8	ppf	ppf	PROPN
admet-2403	44	9	across	across	ADP
admet-2403	44	10	the	the	DET
admet-2403	44	11	rabbit	rabbit	NOUN
admet-2403	44	12	nasal	nasal	PROPN
admet-2403	44	13	mucosa	mucosa	PROPN
admet-2403	44	14	ex	ex	PUNCT
admet-2403	44	15	vivo	vivo	NOUN
admet-2403	44	16	because	because	SCONJ
admet-2403	44	17	the	the	DET
admet-2403	44	18	hoped	hope	VERB
admet-2403	44	19	-	-	PUNCT
admet-2403	44	20	for	for	ADP
admet-2403	44	21	light	light	ADJ
admet-2403	44	22	sedation	sedation	NOUN
admet-2403	44	23	depends	depend	VERB
admet-2403	44	24	on	on	ADP
admet-2403	44	25	the	the	DET
admet-2403	44	26	amount	amount	NOUN
admet-2403	44	27	of	of	ADP
admet-2403	44	28	drug	drug	NOUN
admet-2403	44	29	released	release	VERB
admet-2403	44	30	from	from	ADP
admet-2403	44	31	the	the	DET
admet-2403	44	32	formulation	formulation	NOUN
admet-2403	44	33	and	and	CCONJ
admet-2403	44	34	reaching	reach	VERB
admet-2403	44	35	the	the	DET
admet-2403	44	36	blood	blood	NOUN
admet-2403	44	37	from	from	ADP
admet-2403	44	38	the	the	DET
admet-2403	44	39	nasal	nasal	ADJ
admet-2403	44	40	cavity	cavity	NOUN
admet-2403	44	41	.	.	PUNCT
admet-2403	45	1	the	the	DET
admet-2403	45	2	experiments	experiment	NOUN
admet-2403	45	3	were	be	AUX
admet-2403	45	4	carried	carry	VERB
admet-2403	45	5	out	out	ADP
admet-2403	45	6	by	by	ADP
admet-2403	45	7	using	use	VERB
admet-2403	45	8	franz	franz	NOUN
admet-2403	45	9	-	-	PUNCT
admet-2403	45	10	type	type	NOUN
admet-2403	45	11	diffusion	diffusion	NOUN
admet-2403	45	12	cells	cell	NOUN
admet-2403	45	13	and	and	CCONJ
admet-2403	45	14	rabbit	rabbit	NOUN
admet-2403	45	15	nasal	nasal	PROPN
admet-2403	45	16	mucosa	mucosa	PROPN
admet-2403	45	17	as	as	ADP
admet-2403	45	18	model	model	NOUN
admet-2403	45	19	tissue	tissue	NOUN
admet-2403	46	1	[	[	X
admet-2403	46	2	21	21	NUM
admet-2403	46	3	]	]	PUNCT
admet-2403	46	4	.	.	PUNCT
admet-2403	47	1	the	the	DET
admet-2403	47	2	effect	effect	NOUN
admet-2403	47	3	of	of	ADP
admet-2403	47	4	methyl	methyl	NOUN
admet-2403	47	5	-	-	PUNCT
admet-2403	47	6	β	β	NOUN
admet-2403	47	7	-	-	NOUN
admet-2403	47	8	cyclodextrin	cyclodextrin	NOUN
admet-2403	47	9	on	on	ADP
admet-2403	47	10	ppf	ppf	PROPN
admet-2403	47	11	solubility	solubility	NOUN
admet-2403	47	12	and	and	CCONJ
admet-2403	47	13	permeation	permeation	NOUN
admet-2403	47	14	was	be	AUX
admet-2403	47	15	also	also	ADV
admet-2403	47	16	evaluated	evaluate	VERB
admet-2403	47	17	[	[	X
admet-2403	47	18	2	2	NUM
admet-2403	47	19	]	]	PUNCT
admet-2403	47	20	.	.	PUNCT
admet-2403	48	1	experimental	experimental	ADJ
admet-2403	48	2	materials	material	NOUN
admet-2403	48	3	propofol	propofol	NOUN
admet-2403	48	4	(	(	PUNCT
admet-2403	48	5	ppf	ppf	PROPN
admet-2403	48	6	;	;	PUNCT
admet-2403	48	7	0.96	0.96	NUM
admet-2403	48	8	g	g	NOUN
admet-2403	48	9	/	/	SYM
admet-2403	48	10	ml	ml	NOUN
admet-2403	48	11	density	density	NOUN
admet-2403	48	12	at	at	ADP
admet-2403	48	13	25	25	NUM
admet-2403	48	14	°	°	NOUN
admet-2403	48	15	c	c	NOUN
admet-2403	48	16	)	)	PUNCT
admet-2403	48	17	raw	raw	ADJ
admet-2403	48	18	material	material	NOUN
admet-2403	48	19	(	(	PUNCT
admet-2403	48	20	batch	batch	NOUN
admet-2403	48	21	#	#	NOUN
admet-2403	48	22	fcb050002	fcb050002	NOUN
admet-2403	48	23	)	)	PUNCT
admet-2403	48	24	was	be	AUX
admet-2403	48	25	purchased	purchase	VERB
admet-2403	48	26	from	from	ADP
admet-2403	48	27	fluorochem	fluorochem	NOUN
admet-2403	48	28	(	(	PUNCT
admet-2403	48	29	hadfield	hadfield	PROPN
admet-2403	48	30	,	,	PUNCT
admet-2403	48	31	uk	uk	PROPN
admet-2403	48	32	)	)	PUNCT
admet-2403	48	33	and	and	CCONJ
admet-2403	48	34	used	use	VERB
admet-2403	48	35	as	as	ADP
admet-2403	48	36	an	an	DET
admet-2403	48	37	analytical	analytical	ADJ
admet-2403	48	38	standard	standard	NOUN
admet-2403	48	39	for	for	ADP
admet-2403	48	40	hplc	hplc	NOUN
admet-2403	48	41	analysis	analysis	NOUN
admet-2403	48	42	.	.	PUNCT
admet-2403	49	1	the	the	DET
admet-2403	49	2	commercial	commercial	ADJ
admet-2403	49	3	propofol	propofol	NOUN
admet-2403	49	4	kabi	kabi	X
admet-2403	49	5	injection	injection	NOUN
admet-2403	49	6	(	(	PUNCT
admet-2403	49	7	ppf	ppf	PROPN
admet-2403	49	8	-	-	PUNCT
admet-2403	49	9	fk	fk	PROPN
admet-2403	49	10	;	;	PUNCT
admet-2403	49	11	fresenius	fresenius	PROPN
admet-2403	49	12	kabi	kabi	PROPN
admet-2403	49	13	,	,	PUNCT
admet-2403	49	14	isola	isola	PROPN
admet-2403	49	15	della	della	PROPN
admet-2403	49	16	scala	scala	PROPN
admet-2403	49	17	,	,	PUNCT
admet-2403	49	18	vr	vr	PROPN
admet-2403	49	19	,	,	PUNCT
admet-2403	49	20	italy	italy	PROPN
admet-2403	49	21	)	)	PUNCT
admet-2403	49	22	was	be	AUX
admet-2403	49	23	used	use	VERB
admet-2403	49	24	for	for	ADP
admet-2403	49	25	the	the	DET
admet-2403	49	26	permeation	permeation	NOUN
admet-2403	49	27	experiments	experiment	NOUN
admet-2403	49	28	as	as	ADP
admet-2403	49	29	such	such	ADJ
admet-2403	49	30	or	or	CCONJ
admet-2403	49	31	after	after	ADP
admet-2403	49	32	dilution	dilution	NOUN
admet-2403	49	33	.	.	PUNCT
admet-2403	50	1	ppf	ppf	PROPN
admet-2403	50	2	-	-	PUNCT
admet-2403	50	3	fk	fk	PROPN
admet-2403	50	4	is	be	AUX
admet-2403	50	5	a	a	DET
admet-2403	50	6	milky	milky	ADJ
admet-2403	50	7	white	white	ADJ
admet-2403	50	8	o	o	NOUN
admet-2403	50	9	/	/	SYM
admet-2403	50	10	w	w	NOUN
admet-2403	50	11	emulsion	emulsion	NOUN
admet-2403	50	12	for	for	ADP
admet-2403	50	13	injection	injection	NOUN
admet-2403	50	14	containing	contain	VERB
admet-2403	50	15	10	10	NUM
admet-2403	50	16	mg	mg	NUM
admet-2403	50	17	/	/	SYM
admet-2403	50	18	ml	ml	NOUN
admet-2403	50	19	propofol	propofol	NOUN
admet-2403	50	20	.	.	PUNCT
admet-2403	51	1	it	it	PRON
admet-2403	51	2	is	be	AUX
admet-2403	51	3	packaged	package	VERB
admet-2403	51	4	in	in	ADP
admet-2403	51	5	glass	glass	NOUN
admet-2403	51	6	ampoules	ampoule	NOUN
admet-2403	51	7	containing	contain	VERB
admet-2403	51	8	20	20	NUM
admet-2403	51	9	ml	ml	NOUN
admet-2403	51	10	of	of	ADP
admet-2403	51	11	emulsion	emulsion	NOUN
admet-2403	51	12	and	and	CCONJ
admet-2403	51	13	was	be	AUX
admet-2403	51	14	stored	store	VERB
admet-2403	51	15	in	in	ADP
admet-2403	51	16	the	the	DET
admet-2403	51	17	lab	lab	NOUN
admet-2403	51	18	according	accord	VERB
admet-2403	51	19	to	to	ADP
admet-2403	51	20	the	the	DET
admet-2403	51	21	manufacturer	manufacturer	NOUN
admet-2403	51	22	’s	’s	PART
admet-2403	51	23	instructions	instruction	NOUN
admet-2403	51	24	(	(	PUNCT
admet-2403	51	25	≤25	≤25	ADV
admet-2403	51	26	°	°	NOUN
admet-2403	51	27	c	c	NOUN
admet-2403	51	28	)	)	PUNCT
admet-2403	51	29	.	.	PUNCT
admet-2403	52	1	methyl--cyclodextrin	methyl--cyclodextrin	NOUN
admet-2403	52	2	(	(	PUNCT
admet-2403	52	3	me--cd	me--cd	NOUN
admet-2403	52	4	;	;	PUNCT
admet-2403	52	5	cas	cas	PROPN
admet-2403	52	6	128446	128446	NUM
admet-2403	52	7	-	-	SYM
admet-2403	52	8	36	36	NUM
admet-2403	52	9	-	-	SYM
admet-2403	52	10	6	6	NUM
admet-2403	52	11	)	)	PUNCT
admet-2403	52	12	was	be	AUX
admet-2403	52	13	supplied	supply	VERB
admet-2403	52	14	by	by	ADP
admet-2403	52	15	sigma	sigma	PROPN
admet-2403	52	16	-	-	PUNCT
admet-2403	52	17	aldrich	aldrich	PROPN
admet-2403	52	18	(	(	PUNCT
admet-2403	52	19	darmstadt	darmstadt	PROPN
admet-2403	52	20	,	,	PUNCT
admet-2403	52	21	germany	germany	PROPN
admet-2403	52	22	)	)	PUNCT
admet-2403	52	23	.	.	PUNCT
admet-2403	53	1	hplc	hplc	NOUN
admet-2403	53	2	-	-	PUNCT
admet-2403	53	3	grade	grade	NOUN
admet-2403	53	4	acetonitrile	acetonitrile	NOUN
admet-2403	53	5	and	and	CCONJ
admet-2403	53	6	methanol	methanol	NOUN
admet-2403	53	7	were	be	AUX
admet-2403	53	8	purchased	purchase	VERB
admet-2403	53	9	by	by	ADP
admet-2403	53	10	merck	merck	PROPN
admet-2403	53	11	kgaa	kgaa	PROPN
admet-2403	53	12	(	(	PUNCT
admet-2403	53	13	darmstadt	darmstadt	PROPN
admet-2403	53	14	,	,	PUNCT
admet-2403	53	15	germany	germany	PROPN
admet-2403	53	16	)	)	PUNCT
admet-2403	53	17	.	.	PUNCT
admet-2403	54	1	all	all	DET
admet-2403	54	2	salts	salt	NOUN
admet-2403	54	3	,	,	PUNCT
admet-2403	54	4	reagents	reagent	NOUN
admet-2403	54	5	and	and	CCONJ
admet-2403	54	6	other	other	ADJ
admet-2403	54	7	solvents	solvent	NOUN
admet-2403	54	8	were	be	AUX
admet-2403	54	9	analytical	analytical	ADJ
admet-2403	54	10	grade	grade	NOUN
admet-2403	54	11	.	.	PUNCT
admet-2403	55	1	methods	method	NOUN
admet-2403	55	2	ppf	ppf	PROPN
admet-2403	55	3	equilibrium	equilibrium	NOUN
admet-2403	55	4	solubility	solubility	NOUN
admet-2403	55	5	study	study	VERB
admet-2403	55	6	the	the	DET
admet-2403	55	7	equilibrium	equilibrium	NOUN
admet-2403	55	8	solubility	solubility	NOUN
admet-2403	55	9	of	of	ADP
admet-2403	55	10	ppf	ppf	PROPN
admet-2403	55	11	raw	raw	ADJ
admet-2403	55	12	material	material	NOUN
admet-2403	55	13	was	be	AUX
admet-2403	55	14	investigated	investigate	VERB
admet-2403	55	15	in	in	ADP
admet-2403	55	16	physiological	physiological	ADJ
admet-2403	55	17	saline	saline	NOUN
admet-2403	55	18	solution	solution	NOUN
admet-2403	55	19	(	(	PUNCT
admet-2403	55	20	0.9	0.9	NUM
admet-2403	55	21	%	%	NOUN
admet-2403	55	22	w	w	PROPN
admet-2403	55	23	/	/	SYM
admet-2403	55	24	v	v	NOUN
admet-2403	55	25	nacl	nacl	NOUN
admet-2403	55	26	;	;	PUNCT
admet-2403	55	27	from	from	ADP
admet-2403	55	28	now	now	ADV
admet-2403	55	29	on	on	ADV
admet-2403	55	30	referred	refer	VERB
admet-2403	55	31	to	to	ADP
admet-2403	55	32	as	as	ADP
admet-2403	55	33	“	"	PUNCT
admet-2403	55	34	saline	saline	NOUN
admet-2403	55	35	”	"	PUNCT
admet-2403	55	36	)	)	PUNCT
admet-2403	55	37	using	use	VERB
admet-2403	55	38	the	the	DET
admet-2403	55	39	liquid	liquid	ADJ
admet-2403	55	40	ppf	ppf	PROPN
admet-2403	55	41	raw	raw	ADJ
admet-2403	55	42	material	material	NOUN
admet-2403	55	43	.	.	PUNCT
admet-2403	56	1	an	an	DET
admet-2403	56	2	excess	excess	ADJ
admet-2403	56	3	volume	volume	NOUN
admet-2403	56	4	of	of	ADP
admet-2403	56	5	ppf	ppf	PROPN
admet-2403	56	6	(	(	PUNCT
admet-2403	56	7	about	about	ADV
admet-2403	56	8	200	200	NUM
admet-2403	56	9	µl	µl	NOUN
admet-2403	56	10	)	)	PUNCT
admet-2403	56	11	was	be	AUX
admet-2403	56	12	added	add	VERB
admet-2403	56	13	to	to	ADP
admet-2403	56	14	2	2	NUM
admet-2403	56	15	ml	ml	NOUN
admet-2403	56	16	of	of	ADP
admet-2403	56	17	the	the	DET
admet-2403	56	18	saline	saline	NOUN
admet-2403	56	19	containing	contain	VERB
admet-2403	56	20	increasing	increase	VERB
admet-2403	56	21	concentrations	concentration	NOUN
admet-2403	56	22	of	of	ADP
admet-2403	56	23	me	i	PRON
admet-2403	56	24	-	-	PUNCT
admet-2403	56	25	β	β	NOUN
admet-2403	56	26	-	-	NOUN
admet-2403	56	27	cd	cd	ADJ
admet-2403	56	28	,	,	PUNCT
admet-2403	56	29	namely	namely	ADV
admet-2403	56	30	0.07	0.07	NUM
admet-2403	56	31	,	,	PUNCT
admet-2403	56	32	1.47	1.47	NUM
admet-2403	56	33	admet	admet	X
admet-2403	56	34	&	&	CCONJ
admet-2403	56	35	dmpk	dmpk	PROPN
admet-2403	56	36	12(5	12(5	NUM
admet-2403	56	37	)	)	PUNCT
admet-2403	56	38	(	(	PUNCT
admet-2403	56	39	2024	2024	NUM
admet-2403	56	40	)	)	PUNCT
admet-2403	56	41	759	759	NUM
admet-2403	56	42	-	-	SYM
admet-2403	56	43	768	768	NUM
admet-2403	56	44	a	a	DET
admet-2403	56	45	proof	proof	NOUN
admet-2403	56	46	-	-	PUNCT
admet-2403	56	47	of	of	ADP
admet-2403	56	48	-	-	PUNCT
admet-2403	56	49	concept	concept	NOUN
admet-2403	56	50	study	study	NOUN
admet-2403	56	51	for	for	ADP
admet-2403	56	52	outpatient	outpatient	NOUN
admet-2403	56	53	light	light	ADJ
admet-2403	56	54	sedation	sedation	NOUN
admet-2403	56	55	via	via	ADP
admet-2403	56	56	nasal	nasal	PROPN
admet-2403	56	57	route	route	PROPN
admet-2403	56	58	doi	doi	PROPN
admet-2403	56	59	:	:	PUNCT
admet-2403	56	60	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	56	61	761	761	NUM
admet-2403	56	62	and	and	CCONJ
admet-2403	56	63	2.94	2.94	NUM
admet-2403	56	64	%	%	NOUN
admet-2403	56	65	(	(	PUNCT
admet-2403	56	66	w	w	NOUN
admet-2403	56	67	/	/	SYM
admet-2403	56	68	v	v	NOUN
admet-2403	56	69	)	)	PUNCT
admet-2403	56	70	.	.	PUNCT
admet-2403	57	1	a	a	DET
admet-2403	57	2	fourth	fourth	ADJ
admet-2403	57	3	sample	sample	NOUN
admet-2403	57	4	contained	contain	VERB
admet-2403	57	5	the	the	DET
admet-2403	57	6	saline	saline	NOUN
admet-2403	57	7	without	without	ADP
admet-2403	57	8	me	i	PRON
admet-2403	57	9	-	-	PUNCT
admet-2403	57	10	β	β	NOUN
admet-2403	57	11	-	-	NOUN
admet-2403	57	12	cd	cd	NOUN
admet-2403	57	13	.	.	PUNCT
admet-2403	58	1	in	in	ADP
admet-2403	58	2	all	all	DET
admet-2403	58	3	cases	case	NOUN
admet-2403	58	4	,	,	PUNCT
admet-2403	58	5	liquid	liquid	ADJ
admet-2403	58	6	ppf	ppf	PROPN
admet-2403	58	7	was	be	AUX
admet-2403	58	8	layered	layer	VERB
admet-2403	58	9	on	on	ADP
admet-2403	58	10	top	top	NOUN
admet-2403	58	11	of	of	ADP
admet-2403	58	12	the	the	DET
admet-2403	58	13	aqueous	aqueous	ADJ
admet-2403	58	14	phase	phase	NOUN
admet-2403	58	15	.	.	PUNCT
admet-2403	59	1	then	then	ADV
admet-2403	59	2	,	,	PUNCT
admet-2403	59	3	the	the	DET
admet-2403	59	4	vials	vial	NOUN
admet-2403	59	5	were	be	AUX
admet-2403	59	6	screw	screw	NOUN
admet-2403	59	7	-	-	PUNCT
admet-2403	59	8	capped	cap	VERB
admet-2403	59	9	and	and	CCONJ
admet-2403	59	10	placed	place	VERB
admet-2403	59	11	on	on	ADP
admet-2403	59	12	an	an	DET
admet-2403	59	13	orbital	orbital	ADJ
admet-2403	59	14	shaker	shaker	NOUN
admet-2403	59	15	(	(	PUNCT
admet-2403	59	16	100	100	NUM
admet-2403	59	17	rpm	rpm	NOUN
admet-2403	59	18	;	;	PUNCT
admet-2403	59	19	25	25	NUM
admet-2403	59	20	°	°	NOUN
admet-2403	59	21	c	c	NOUN
admet-2403	59	22	)	)	PUNCT
admet-2403	59	23	for	for	ADP
admet-2403	59	24	22	22	NUM
admet-2403	59	25	hours	hour	NOUN
admet-2403	59	26	.	.	PUNCT
admet-2403	60	1	after	after	ADP
admet-2403	60	2	2	2	NUM
admet-2403	60	3	h	h	NOUN
admet-2403	60	4	of	of	ADP
admet-2403	60	5	vial	vial	ADJ
admet-2403	60	6	rest	rest	NOUN
admet-2403	60	7	without	without	ADP
admet-2403	60	8	shaking	shake	VERB
admet-2403	60	9	,	,	PUNCT
admet-2403	60	10	a	a	DET
admet-2403	60	11	sample	sample	NOUN
admet-2403	60	12	of	of	ADP
admet-2403	60	13	the	the	DET
admet-2403	60	14	aqueous	aqueous	ADJ
admet-2403	60	15	layer	layer	NOUN
admet-2403	60	16	at	at	ADP
admet-2403	60	17	the	the	DET
admet-2403	60	18	bottom	bottom	NOUN
admet-2403	60	19	was	be	AUX
admet-2403	60	20	carefully	carefully	ADV
admet-2403	60	21	withdrawn	withdraw	VERB
admet-2403	60	22	using	use	VERB
admet-2403	60	23	a	a	DET
admet-2403	60	24	hamilton	hamilton	PROPN
admet-2403	60	25	syringe	syringe	NOUN
admet-2403	60	26	and	and	CCONJ
admet-2403	60	27	centrifuged	centrifuge	VERB
admet-2403	60	28	(	(	PUNCT
admet-2403	60	29	10,000	10,000	NUM
admet-2403	60	30	rpm	rpm	NOUN
admet-2403	60	31	,	,	PUNCT
admet-2403	60	32	15	15	NUM
admet-2403	60	33	min	min	NOUN
admet-2403	60	34	)	)	PUNCT
admet-2403	60	35	.	.	PUNCT
admet-2403	61	1	the	the	DET
admet-2403	61	2	collected	collect	VERB
admet-2403	61	3	samples	sample	NOUN
admet-2403	61	4	were	be	AUX
admet-2403	61	5	diluted	dilute	VERB
admet-2403	61	6	with	with	ADP
admet-2403	61	7	methanol	methanol	NOUN
admet-2403	61	8	for	for	ADP
admet-2403	61	9	hplc	hplc	NOUN
admet-2403	61	10	analysis	analysis	NOUN
admet-2403	61	11	.	.	PUNCT
admet-2403	62	1	the	the	DET
admet-2403	62	2	experiment	experiment	NOUN
admet-2403	62	3	was	be	AUX
admet-2403	62	4	conducted	conduct	VERB
admet-2403	62	5	in	in	ADP
admet-2403	62	6	duplicate	duplicate	NOUN
admet-2403	62	7	.	.	PUNCT
admet-2403	63	1	ppf	ppf	PROPN
admet-2403	63	2	permeation	permeation	NOUN
admet-2403	63	3	experiments	experiment	NOUN
admet-2403	63	4	ex	ex	PRON
admet-2403	63	5	vivo	vivo	VERB
admet-2403	63	6	the	the	DET
admet-2403	63	7	ex	ex	X
admet-2403	63	8	vivo	vivo	NOUN
admet-2403	63	9	permeation	permeation	NOUN
admet-2403	63	10	experiments	experiment	NOUN
admet-2403	63	11	were	be	AUX
admet-2403	63	12	carried	carry	VERB
admet-2403	63	13	out	out	ADP
admet-2403	63	14	according	accord	VERB
admet-2403	63	15	to	to	ADP
admet-2403	63	16	a	a	DET
admet-2403	63	17	consolidated	consolidated	ADJ
admet-2403	63	18	protocol	protocol	NOUN
admet-2403	63	19	of	of	ADP
admet-2403	63	20	the	the	DET
admet-2403	63	21	lab	lab	NOUN
admet-2403	64	1	[	[	X
admet-2403	64	2	22	22	NUM
admet-2403	64	3	-	-	SYM
admet-2403	64	4	25	25	NUM
admet-2403	64	5	]	]	PUNCT
admet-2403	64	6	.	.	PUNCT
admet-2403	65	1	vertical	vertical	ADJ
admet-2403	65	2	franz	franz	NOUN
admet-2403	65	3	-	-	PUNCT
admet-2403	65	4	type	type	NOUN
admet-2403	65	5	diffusion	diffusion	NOUN
admet-2403	65	6	cells	cell	NOUN
admet-2403	65	7	(	(	PUNCT
admet-2403	65	8	area	area	NOUN
admet-2403	65	9	0.58	0.58	NUM
admet-2403	65	10	cm2	cm2	NOUN
admet-2403	65	11	)	)	PUNCT
admet-2403	65	12	and	and	CCONJ
admet-2403	65	13	excised	excise	VERB
admet-2403	65	14	rabbit	rabbit	NOUN
admet-2403	65	15	nasal	nasal	PROPN
admet-2403	65	16	mucosa	mucosa	PROPN
admet-2403	65	17	from	from	ADP
admet-2403	65	18	slaughterhouse	slaughterhouse	PROPN
admet-2403	65	19	waste	waste	PROPN
admet-2403	65	20	(	(	PUNCT
admet-2403	65	21	pola	pola	PROPN
admet-2403	65	22	srl	srl	PROPN
admet-2403	65	23	,	,	PUNCT
admet-2403	65	24	finale	finale	PROPN
admet-2403	65	25	emilia	emilia	PROPN
admet-2403	65	26	,	,	PUNCT
admet-2403	65	27	mo	mo	PROPN
admet-2403	65	28	,	,	PUNCT
admet-2403	65	29	italy	italy	PROPN
admet-2403	65	30	)	)	PUNCT
admet-2403	65	31	were	be	AUX
admet-2403	65	32	used	use	VERB
admet-2403	65	33	.	.	PUNCT
admet-2403	66	1	the	the	DET
admet-2403	66	2	tissue	tissue	NOUN
admet-2403	66	3	was	be	AUX
admet-2403	66	4	extracted	extract	VERB
admet-2403	66	5	within	within	ADP
admet-2403	66	6	2	2	NUM
admet-2403	66	7	-	-	SYM
admet-2403	66	8	3	3	NUM
admet-2403	66	9	h	h	NOUN
admet-2403	66	10	from	from	ADP
admet-2403	66	11	the	the	DET
admet-2403	66	12	animal	animal	NOUN
admet-2403	66	13	’s	’s	PART
admet-2403	66	14	death	death	NOUN
admet-2403	66	15	and	and	CCONJ
admet-2403	66	16	inserted	insert	VERB
admet-2403	66	17	between	between	ADP
admet-2403	66	18	the	the	DET
admet-2403	66	19	cell	cell	NOUN
admet-2403	66	20	donor	donor	NOUN
admet-2403	66	21	and	and	CCONJ
admet-2403	66	22	receptor	receptor	NOUN
admet-2403	66	23	compartments	compartment	NOUN
admet-2403	66	24	.	.	PUNCT
admet-2403	67	1	after	after	ADP
admet-2403	67	2	clamping	clamp	VERB
admet-2403	67	3	the	the	DET
admet-2403	67	4	compartments	compartment	NOUN
admet-2403	67	5	together	together	ADV
admet-2403	67	6	,	,	PUNCT
admet-2403	67	7	the	the	DET
admet-2403	67	8	assembly	assembly	NOUN
admet-2403	67	9	tightness	tightness	NOUN
admet-2403	67	10	was	be	AUX
admet-2403	67	11	verified	verify	VERB
admet-2403	67	12	by	by	ADP
admet-2403	67	13	loading	load	VERB
admet-2403	67	14	200	200	NUM
admet-2403	67	15	µl	µl	NOUN
admet-2403	67	16	of	of	ADP
admet-2403	67	17	saline	saline	ADJ
admet-2403	67	18	solution	solution	NOUN
admet-2403	67	19	into	into	ADP
admet-2403	67	20	the	the	DET
admet-2403	67	21	donor	donor	NOUN
admet-2403	67	22	and	and	CCONJ
admet-2403	67	23	checking	check	VERB
admet-2403	67	24	for	for	ADP
admet-2403	67	25	any	any	DET
admet-2403	67	26	leakage	leakage	NOUN
admet-2403	67	27	.	.	PUNCT
admet-2403	68	1	then	then	ADV
admet-2403	68	2	,	,	PUNCT
admet-2403	68	3	the	the	DET
admet-2403	68	4	lower	low	ADJ
admet-2403	68	5	compartment	compartment	NOUN
admet-2403	68	6	was	be	AUX
admet-2403	68	7	accurately	accurately	ADV
admet-2403	68	8	filled	fill	VERB
admet-2403	68	9	with	with	ADP
admet-2403	68	10	4.7	4.7	NUM
admet-2403	68	11	ml	ml	NOUN
admet-2403	68	12	of	of	ADP
admet-2403	68	13	me	i	PRON
admet-2403	68	14	-	-	PUNCT
admet-2403	68	15	β	β	NOUN
admet-2403	68	16	-	-	NOUN
admet-2403	68	17	cd	cd	INTJ
admet-2403	68	18	(	(	PUNCT
admet-2403	68	19	0.07	0.07	NUM
admet-2403	68	20	%	%	NOUN
admet-2403	68	21	w	w	PROPN
admet-2403	68	22	/	/	SYM
admet-2403	68	23	v	v	NOUN
admet-2403	68	24	)	)	PUNCT
admet-2403	68	25	in	in	ADP
admet-2403	68	26	saline	saline	NOUN
admet-2403	68	27	as	as	ADP
admet-2403	68	28	the	the	DET
admet-2403	68	29	receiving	receive	VERB
admet-2403	68	30	medium	medium	NOUN
admet-2403	68	31	.	.	PUNCT
admet-2403	69	1	after	after	ADP
admet-2403	69	2	15	15	NUM
admet-2403	69	3	min	min	NOUN
admet-2403	69	4	equilibration	equilibration	NOUN
admet-2403	69	5	at	at	ADP
admet-2403	69	6	37	37	NUM
admet-2403	69	7	°	°	NOUN
admet-2403	69	8	c	c	NOUN
admet-2403	69	9	,	,	PUNCT
admet-2403	69	10	the	the	DET
admet-2403	69	11	donor	donor	NOUN
admet-2403	69	12	compartment	compartment	NOUN
admet-2403	69	13	was	be	AUX
admet-2403	69	14	loaded	load	VERB
admet-2403	69	15	either	either	CCONJ
admet-2403	69	16	with	with	ADP
admet-2403	69	17	1	1	NUM
admet-2403	69	18	ml	ml	NOUN
admet-2403	69	19	of	of	ADP
admet-2403	69	20	ppf	ppf	PROPN
admet-2403	69	21	-	-	PUNCT
admet-2403	69	22	fk	fk	NOUN
admet-2403	69	23	emulsion	emulsion	NOUN
admet-2403	69	24	as	as	SCONJ
admet-2403	69	25	such	such	ADJ
admet-2403	69	26	(	(	PUNCT
admet-2403	69	27	10	10	NUM
admet-2403	69	28	mg	mg	NOUN
admet-2403	69	29	ppf	ppf	PROPN
admet-2403	69	30	loaded	load	VERB
admet-2403	69	31	)	)	PUNCT
admet-2403	69	32	or	or	CCONJ
admet-2403	69	33	ppf	ppf	PROPN
admet-2403	69	34	-	-	PUNCT
admet-2403	69	35	fk	fk	INTJ
admet-2403	69	36	diluted	dilute	VERB
admet-2403	69	37	1:5	1:5	NUM
admet-2403	69	38	with	with	ADP
admet-2403	69	39	saline	saline	NOUN
admet-2403	69	40	without	without	ADP
admet-2403	69	41	or	or	CCONJ
admet-2403	69	42	with	with	ADP
admet-2403	69	43	me	i	PRON
admet-2403	69	44	-	-	PUNCT
admet-2403	69	45	β	β	NOUN
admet-2403	69	46	-	-	NOUN
admet-2403	69	47	cd	cd	NOUN
admet-2403	69	48	(	(	PUNCT
admet-2403	69	49	2	2	NUM
admet-2403	69	50	mg	mg	PROPN
admet-2403	69	51	ppf	ppf	PROPN
admet-2403	69	52	loaded	load	VERB
admet-2403	69	53	;	;	PUNCT
admet-2403	69	54	2.94	2.94	NUM
admet-2403	69	55	%	%	NOUN
admet-2403	69	56	w	w	PROPN
admet-2403	69	57	/	/	SYM
admet-2403	69	58	v	v	PRON
admet-2403	69	59	me	me	NOUN
admet-2403	69	60	-	-	PUNCT
admet-2403	69	61	β	β	NOUN
admet-2403	69	62	-	-	NOUN
admet-2403	69	63	cd	cd	NOUN
admet-2403	69	64	)	)	PUNCT
admet-2403	69	65	.	.	PUNCT
admet-2403	70	1	the	the	DET
admet-2403	70	2	experiments	experiment	NOUN
admet-2403	70	3	lasted	last	VERB
admet-2403	70	4	3	3	NUM
admet-2403	70	5	hours	hour	NOUN
admet-2403	70	6	with	with	ADP
admet-2403	70	7	the	the	DET
admet-2403	70	8	medium	medium	NOUN
admet-2403	70	9	magnetically	magnetically	ADV
admet-2403	70	10	stirred	stir	VERB
admet-2403	70	11	(	(	PUNCT
admet-2403	70	12	250	250	NUM
admet-2403	70	13	rpm	rpm	NOUN
admet-2403	70	14	)	)	PUNCT
admet-2403	70	15	.	.	PUNCT
admet-2403	71	1	at	at	ADP
admet-2403	71	2	pre	pre	ADJ
admet-2403	71	3	-	-	ADJ
admet-2403	71	4	determined	determined	ADJ
admet-2403	71	5	time	time	NOUN
admet-2403	71	6	points	point	NOUN
admet-2403	71	7	,	,	PUNCT
admet-2403	71	8	0.5	0.5	NUM
admet-2403	71	9	ml	ml	NOUN
admet-2403	71	10	of	of	ADP
admet-2403	71	11	medium	medium	NOUN
admet-2403	71	12	was	be	AUX
admet-2403	71	13	sampled	sample	VERB
admet-2403	71	14	and	and	CCONJ
admet-2403	71	15	replaced	replace	VERB
admet-2403	71	16	with	with	ADP
admet-2403	71	17	an	an	DET
admet-2403	71	18	equal	equal	ADJ
admet-2403	71	19	volume	volume	NOUN
admet-2403	71	20	of	of	ADP
admet-2403	71	21	fresh	fresh	ADJ
admet-2403	71	22	medium	medium	NOUN
admet-2403	71	23	.	.	PUNCT
admet-2403	72	1	after	after	ADP
admet-2403	72	2	the	the	DET
admet-2403	72	3	last	last	ADJ
admet-2403	72	4	sampling	sampling	NOUN
admet-2403	72	5	,	,	PUNCT
admet-2403	72	6	100	100	NUM
admet-2403	72	7	µl	µl	NOUN
admet-2403	72	8	of	of	ADP
admet-2403	72	9	the	the	DET
admet-2403	72	10	residual	residual	ADJ
admet-2403	72	11	formulation	formulation	NOUN
admet-2403	72	12	in	in	ADP
admet-2403	72	13	the	the	DET
admet-2403	72	14	donor	donor	NOUN
admet-2403	72	15	compartment	compartment	NOUN
admet-2403	72	16	was	be	AUX
admet-2403	72	17	collected	collect	VERB
admet-2403	72	18	for	for	ADP
admet-2403	72	19	ppf	ppf	PROPN
admet-2403	72	20	quantification	quantification	NOUN
admet-2403	72	21	and	and	CCONJ
admet-2403	72	22	mass	mass	NOUN
admet-2403	72	23	balance	balance	NOUN
admet-2403	72	24	calculation	calculation	NOUN
admet-2403	72	25	.	.	PUNCT
admet-2403	73	1	this	this	DET
admet-2403	73	2	aliquot	aliquot	NOUN
admet-2403	73	3	was	be	AUX
admet-2403	73	4	diluted	dilute	VERB
admet-2403	73	5	with	with	ADP
admet-2403	73	6	methanol	methanol	NOUN
admet-2403	73	7	,	,	PUNCT
admet-2403	73	8	the	the	DET
admet-2403	73	9	obtained	obtain	VERB
admet-2403	73	10	solution	solution	NOUN
admet-2403	73	11	centrifuged	centrifuge	VERB
admet-2403	73	12	(	(	PUNCT
admet-2403	73	13	10,000	10,000	NUM
admet-2403	73	14	rpm	rpm	NOUN
admet-2403	73	15	,	,	PUNCT
admet-2403	73	16	5	5	NUM
admet-2403	73	17	min	min	NOUN
admet-2403	73	18	)	)	PUNCT
admet-2403	73	19	,	,	PUNCT
admet-2403	73	20	and	and	CCONJ
admet-2403	73	21	the	the	DET
admet-2403	73	22	supernatant	supernatant	NOUN
admet-2403	73	23	injected	inject	VERB
admet-2403	73	24	in	in	ADP
admet-2403	73	25	hplc	hplc	NOUN
admet-2403	73	26	.	.	PUNCT
admet-2403	74	1	the	the	DET
admet-2403	74	2	mucosa	mucosa	NOUN
admet-2403	74	3	specimen	speciman	NOUN
admet-2403	74	4	was	be	AUX
admet-2403	74	5	collected	collect	VERB
admet-2403	74	6	,	,	PUNCT
admet-2403	74	7	rinsed	rinse	VERB
admet-2403	74	8	,	,	PUNCT
admet-2403	74	9	and	and	CCONJ
admet-2403	74	10	frozen	frozen	ADJ
admet-2403	74	11	.	.	PUNCT
admet-2403	75	1	on	on	ADP
admet-2403	75	2	the	the	DET
admet-2403	75	3	day	day	NOUN
admet-2403	75	4	of	of	ADP
admet-2403	75	5	analysis	analysis	NOUN
admet-2403	75	6	,	,	PUNCT
admet-2403	75	7	it	it	PRON
admet-2403	75	8	was	be	AUX
admet-2403	75	9	thawed	thaw	VERB
admet-2403	75	10	and	and	CCONJ
admet-2403	75	11	finely	finely	ADV
admet-2403	75	12	cut	cut	VERB
admet-2403	75	13	with	with	ADP
admet-2403	75	14	a	a	DET
admet-2403	75	15	surgical	surgical	ADJ
admet-2403	75	16	blade	blade	NOUN
admet-2403	75	17	to	to	PART
admet-2403	75	18	extract	extract	VERB
admet-2403	75	19	ppf	ppf	PROPN
admet-2403	75	20	with	with	ADP
admet-2403	75	21	water	water	NOUN
admet-2403	75	22	and	and	CCONJ
admet-2403	75	23	methanol	methanol	NOUN
admet-2403	75	24	by	by	ADP
admet-2403	75	25	manual	manual	ADJ
admet-2403	75	26	homogenization	homogenization	NOUN
admet-2403	75	27	with	with	ADP
admet-2403	75	28	a	a	DET
admet-2403	75	29	pestle	pestle	NOUN
admet-2403	75	30	.	.	PUNCT
admet-2403	76	1	the	the	DET
admet-2403	76	2	resulting	result	VERB
admet-2403	76	3	suspension	suspension	NOUN
admet-2403	76	4	was	be	AUX
admet-2403	76	5	centrifuged	centrifuge	VERB
admet-2403	76	6	(	(	PUNCT
admet-2403	76	7	10,000	10,000	NUM
admet-2403	76	8	rpm	rpm	NOUN
admet-2403	76	9	,	,	PUNCT
admet-2403	76	10	10	10	NUM
admet-2403	76	11	min	min	NOUN
admet-2403	76	12	)	)	PUNCT
admet-2403	76	13	,	,	PUNCT
admet-2403	76	14	and	and	CCONJ
admet-2403	76	15	the	the	DET
admet-2403	76	16	supernatant	supernatant	NOUN
admet-2403	76	17	was	be	AUX
admet-2403	76	18	injected	inject	VERB
admet-2403	76	19	to	to	PART
admet-2403	76	20	quantify	quantify	VERB
admet-2403	76	21	the	the	DET
admet-2403	76	22	ppf	ppf	PROPN
admet-2403	76	23	extracted	extract	VERB
admet-2403	76	24	.	.	PUNCT
admet-2403	77	1	finally	finally	ADV
admet-2403	77	2	,	,	PUNCT
admet-2403	77	3	the	the	DET
admet-2403	77	4	samples	sample	NOUN
admet-2403	77	5	withdrawn	withdraw	VERB
admet-2403	77	6	from	from	ADP
admet-2403	77	7	the	the	DET
admet-2403	77	8	receptor	receptor	NOUN
admet-2403	77	9	were	be	AUX
admet-2403	77	10	centrifuged	centrifuge	VERB
admet-2403	77	11	(	(	PUNCT
admet-2403	77	12	10,000	10,000	NUM
admet-2403	77	13	rpm	rpm	NOUN
admet-2403	77	14	,	,	PUNCT
admet-2403	77	15	10	10	NUM
admet-2403	77	16	min	min	NOUN
admet-2403	77	17	)	)	PUNCT
admet-2403	77	18	,	,	PUNCT
admet-2403	77	19	and	and	CCONJ
admet-2403	77	20	the	the	DET
admet-2403	77	21	supernatant	supernatant	NOUN
admet-2403	77	22	was	be	AUX
admet-2403	77	23	injected	inject	VERB
admet-2403	77	24	.	.	PUNCT
admet-2403	78	1	hplc	hplc	NOUN
admet-2403	78	2	-	-	PUNCT
admet-2403	78	3	uv	uv	NOUN
admet-2403	78	4	method	method	NOUN
admet-2403	78	5	for	for	ADP
admet-2403	78	6	propofol	propofol	ADJ
admet-2403	78	7	quantification	quantification	NOUN
admet-2403	78	8	ppf	ppf	PROPN
admet-2403	78	9	concentration	concentration	NOUN
admet-2403	78	10	in	in	ADP
admet-2403	78	11	the	the	DET
admet-2403	78	12	samples	sample	NOUN
admet-2403	78	13	was	be	AUX
admet-2403	78	14	determined	determine	VERB
admet-2403	78	15	by	by	ADP
admet-2403	78	16	hplc	hplc	NOUN
admet-2403	78	17	-	-	PUNCT
admet-2403	78	18	uv	uv	NOUN
admet-2403	78	19	on	on	ADP
admet-2403	78	20	an	an	DET
admet-2403	78	21	agilent	agilent	PROPN
admet-2403	78	22	series	series	PROPN
admet-2403	78	23	1100	1100	NUM
admet-2403	78	24	apparatus	apparatus	PROPN
admet-2403	78	25	with	with	ADP
admet-2403	78	26	uvvis	uvvis	PROPN
admet-2403	78	27	detection	detection	NOUN
admet-2403	78	28	(	(	PUNCT
admet-2403	78	29	software	software	NOUN
admet-2403	78	30	chemstation	chemstation	NOUN
admet-2403	78	31	v.	v.	ADP
admet-2403	78	32	b.04.03	b.04.03	NOUN
admet-2403	78	33	)	)	PUNCT
admet-2403	78	34	.	.	PUNCT
admet-2403	79	1	the	the	DET
admet-2403	79	2	stationary	stationary	ADJ
admet-2403	79	3	phase	phase	NOUN
admet-2403	79	4	was	be	AUX
admet-2403	79	5	a	a	DET
admet-2403	79	6	luna	luna	PROPN
admet-2403	79	7	c18	c18	PROPN
admet-2403	79	8	column	column	NOUN
admet-2403	79	9	(	(	PUNCT
admet-2403	79	10	3	3	NUM
admet-2403	79	11	µm	µm	NOUN
admet-2403	79	12	,	,	PUNCT
admet-2403	79	13	150×4.60	150×4.60	PROPN
admet-2403	79	14	mm	mm	INTJ
admet-2403	79	15	;	;	PUNCT
admet-2403	79	16	phenomenex	phenomenex	ADV
admet-2403	79	17	,	,	PUNCT
admet-2403	79	18	torrance	torrance	NOUN
admet-2403	79	19	,	,	PUNCT
admet-2403	79	20	ca	ca	NOUN
admet-2403	79	21	,	,	PUNCT
admet-2403	79	22	usa	usa	PROPN
admet-2403	79	23	)	)	PUNCT
admet-2403	79	24	.	.	PUNCT
admet-2403	80	1	the	the	DET
admet-2403	80	2	mobile	mobile	ADJ
admet-2403	80	3	phase	phase	NOUN
admet-2403	80	4	was	be	AUX
admet-2403	80	5	composed	compose	VERB
admet-2403	80	6	of	of	ADP
admet-2403	80	7	20	20	NUM
admet-2403	80	8	mm	mm	PROPN
admet-2403	80	9	kh2po4	kh2po4	NOUN
admet-2403	80	10	:	:	PUNCT
admet-2403	80	11	acetonitrile	acetonitrile	NOUN
admet-2403	80	12	(	(	PUNCT
admet-2403	80	13	16:84	16:84	NUM
admet-2403	80	14	)	)	PUNCT
admet-2403	80	15	,	,	PUNCT
admet-2403	80	16	ph	ph	NOUN
admet-2403	80	17	3.0	3.0	NUM
admet-2403	80	18	,	,	PUNCT
admet-2403	80	19	for	for	ADP
admet-2403	80	20	isocratic	isocratic	ADJ
admet-2403	80	21	elution	elution	NOUN
admet-2403	80	22	at	at	ADP
admet-2403	80	23	0.8	0.8	NUM
admet-2403	80	24	ml	ml	NOUN
admet-2403	80	25	/	/	SYM
admet-2403	80	26	min	min	NOUN
admet-2403	80	27	flow	flow	NOUN
admet-2403	80	28	rate	rate	NOUN
admet-2403	80	29	(	(	PUNCT
admet-2403	80	30	backpressure	backpressure	NOUN
admet-2403	80	31	78	78	NUM
admet-2403	80	32	-	-	SYM
admet-2403	80	33	80	80	NUM
admet-2403	80	34	bar	bar	NOUN
admet-2403	80	35	at	at	ADP
admet-2403	80	36	t	t	PROPN
admet-2403	80	37	≤25	≤25	ADV
admet-2403	81	1	°	°	ADP
admet-2403	81	2	c	c	NOUN
admet-2403	81	3	)	)	PUNCT
admet-2403	81	4	.	.	PUNCT
admet-2403	82	1	absorbance	absorbance	NOUN
admet-2403	82	2	was	be	AUX
admet-2403	82	3	measured	measure	VERB
admet-2403	82	4	at	at	ADP
admet-2403	82	5	220	220	NUM
admet-2403	82	6	nm	nm	NOUN
admet-2403	82	7	.	.	PUNCT
admet-2403	83	1	in	in	ADP
admet-2403	83	2	these	these	DET
admet-2403	83	3	conditions	condition	NOUN
admet-2403	83	4	,	,	PUNCT
admet-2403	83	5	the	the	DET
admet-2403	83	6	retention	retention	NOUN
admet-2403	83	7	time	time	NOUN
admet-2403	83	8	of	of	ADP
admet-2403	83	9	propofol	propofol	NOUN
admet-2403	83	10	was	be	AUX
admet-2403	83	11	3.2	3.2	NUM
admet-2403	83	12	minutes	minute	NOUN
admet-2403	83	13	.	.	PUNCT
admet-2403	84	1	the	the	DET
admet-2403	84	2	propofol	propofol	ADJ
admet-2403	84	3	standard	standard	ADJ
admet-2403	84	4	solution	solution	NOUN
admet-2403	84	5	was	be	AUX
admet-2403	84	6	prepared	prepare	VERB
admet-2403	84	7	by	by	ADP
admet-2403	84	8	diluting	dilute	VERB
admet-2403	84	9	50	50	NUM
admet-2403	84	10	µl	µl	NOUN
admet-2403	84	11	of	of	ADP
admet-2403	84	12	ppf	ppf	PROPN
admet-2403	84	13	raw	raw	ADJ
admet-2403	84	14	material	material	NOUN
admet-2403	84	15	into	into	ADP
admet-2403	84	16	20	20	NUM
admet-2403	84	17	ml	ml	NOUN
admet-2403	84	18	with	with	ADP
admet-2403	84	19	methanol	methanol	NOUN
admet-2403	84	20	(	(	PUNCT
admet-2403	84	21	stock	stock	NOUN
admet-2403	84	22	solution	solution	NOUN
admet-2403	84	23	)	)	PUNCT
admet-2403	84	24	.	.	PUNCT
admet-2403	85	1	50	50	NUM
admet-2403	85	2	µl	µl	NOUN
admet-2403	85	3	of	of	ADP
admet-2403	85	4	stock	stock	NOUN
admet-2403	85	5	solution	solution	NOUN
admet-2403	85	6	was	be	AUX
admet-2403	85	7	further	far	ADV
admet-2403	85	8	diluted	dilute	VERB
admet-2403	85	9	to	to	ADP
admet-2403	85	10	10	10	NUM
admet-2403	85	11	ml	ml	NOUN
admet-2403	85	12	with	with	ADP
admet-2403	85	13	methanol	methanol	NOUN
admet-2403	85	14	(	(	PUNCT
admet-2403	85	15	standard	standard	ADJ
admet-2403	85	16	solution	solution	NOUN
admet-2403	85	17	;	;	PUNCT
admet-2403	85	18	12	12	NUM
admet-2403	85	19	µg	µg	NOUN
admet-2403	85	20	/	/	SYM
admet-2403	85	21	ml	ml	NOUN
admet-2403	85	22	)	)	PUNCT
admet-2403	85	23	.	.	PUNCT
admet-2403	86	1	stock	stock	NOUN
admet-2403	86	2	and	and	CCONJ
admet-2403	86	3	standard	standard	ADJ
admet-2403	86	4	solutions	solution	NOUN
admet-2403	86	5	were	be	AUX
admet-2403	86	6	freshly	freshly	ADV
admet-2403	86	7	prepared	prepare	VERB
admet-2403	86	8	on	on	ADP
admet-2403	86	9	each	each	DET
admet-2403	86	10	day	day	NOUN
admet-2403	86	11	of	of	ADP
admet-2403	86	12	analysis	analysis	NOUN
admet-2403	86	13	.	.	PUNCT
admet-2403	87	1	the	the	DET
admet-2403	87	2	method	method	NOUN
admet-2403	87	3	linearity	linearity	NOUN
admet-2403	87	4	was	be	AUX
admet-2403	87	5	verified	verify	VERB
admet-2403	87	6	by	by	ADP
admet-2403	87	7	analyzing	analyze	VERB
admet-2403	87	8	a	a	DET
admet-2403	87	9	series	series	NOUN
admet-2403	87	10	of	of	ADP
admet-2403	87	11	ppf	ppf	PROPN
admet-2403	87	12	solutions	solution	NOUN
admet-2403	87	13	in	in	ADP
admet-2403	87	14	methanol	methanol	NOUN
admet-2403	87	15	(	(	PUNCT
admet-2403	87	16	1.0	1.0	NUM
admet-2403	87	17	,	,	PUNCT
admet-2403	87	18	2.5	2.5	NUM
admet-2403	87	19	,	,	PUNCT
admet-2403	87	20	5.0	5.0	NUM
admet-2403	87	21	,	,	PUNCT
admet-2403	87	22	10.0	10.0	NUM
admet-2403	87	23	,	,	PUNCT
admet-2403	87	24	20.0	20.0	NUM
admet-2403	87	25	μg	μg	NOUN
admet-2403	87	26	/	/	SYM
admet-2403	87	27	ml	ml	NOUN
admet-2403	87	28	)	)	PUNCT
admet-2403	87	29	.	.	PUNCT
admet-2403	88	1	each	each	DET
admet-2403	88	2	concentration	concentration	NOUN
admet-2403	88	3	was	be	AUX
admet-2403	88	4	injected	inject	VERB
admet-2403	88	5	in	in	ADP
admet-2403	88	6	triplicate	triplicate	PROPN
admet-2403	88	7	(	(	PUNCT
admet-2403	88	8	vinj	vinj	NOUN
admet-2403	88	9	:	:	PUNCT
admet-2403	88	10	10	10	NUM
admet-2403	88	11	µl	µl	NOUN
admet-2403	88	12	)	)	PUNCT
admet-2403	88	13	.	.	PUNCT
admet-2403	89	1	a	a	DET
admet-2403	89	2	straight	straight	ADJ
admet-2403	89	3	line	line	NOUN
admet-2403	89	4	was	be	AUX
admet-2403	89	5	obtained	obtain	VERB
admet-2403	89	6	in	in	ADP
admet-2403	89	7	the	the	DET
admet-2403	89	8	considered	consider	VERB
admet-2403	89	9	concentration	concentration	NOUN
admet-2403	89	10	range	range	NOUN
admet-2403	89	11	(	(	PUNCT
admet-2403	89	12	y	y	NOUN
admet-2403	89	13	=	=	SYM
admet-2403	89	14	28.951x	28.951x	NUM
admet-2403	89	15	+	+	CCONJ
admet-2403	89	16	0.9417	0.9417	NUM
admet-2403	89	17	;	;	PUNCT
admet-2403	89	18	r2	r2	PROPN
admet-2403	89	19	=	=	PUNCT
admet-2403	89	20	0.9998	0.9998	NUM
admet-2403	89	21	)	)	PUNCT
admet-2403	89	22	.	.	PUNCT
admet-2403	90	1	moreover	moreover	ADV
admet-2403	90	2	,	,	PUNCT
admet-2403	90	3	using	use	VERB
admet-2403	90	4	the	the	DET
admet-2403	90	5	signal	signal	NOUN
admet-2403	90	6	-	-	PUNCT
admet-2403	90	7	to	to	ADP
admet-2403	90	8	-	-	PUNCT
admet-2403	90	9	noise	noise	NOUN
admet-2403	90	10	ratio	ratio	NOUN
admet-2403	90	11	method	method	NOUN
admet-2403	90	12	,	,	PUNCT
admet-2403	90	13	the	the	DET
admet-2403	90	14	limit	limit	NOUN
admet-2403	90	15	of	of	ADP
admet-2403	90	16	quantification	quantification	NOUN
admet-2403	90	17	(	(	PUNCT
admet-2403	90	18	loq	loq	PROPN
admet-2403	90	19	)	)	PUNCT
admet-2403	90	20	was	be	AUX
admet-2403	90	21	determined	determine	VERB
admet-2403	90	22	at	at	ADP
admet-2403	90	23	0.25	0.25	NUM
admet-2403	90	24	µg	µg	NOUN
admet-2403	90	25	/	/	SYM
admet-2403	90	26	ml	ml	NOUN
admet-2403	90	27	.	.	PUNCT
admet-2403	91	1	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	91	2	m.	m.	PROPN
admet-2403	91	3	d.	d.	PROPN
admet-2403	91	4	spampinato	spampinato	PROPN
admet-2403	91	5	et	et	PROPN
admet-2403	91	6	al	al	PROPN
admet-2403	91	7	.	.	PROPN
admet-2403	91	8	admet	admet	PROPN
admet-2403	91	9	&	&	CCONJ
admet-2403	91	10	dmpk	dmpk	PROPN
admet-2403	91	11	12(5	12(5	NUM
admet-2403	91	12	)	)	PUNCT
admet-2403	91	13	(	(	PUNCT
admet-2403	91	14	2024	2024	NUM
admet-2403	91	15	)	)	PUNCT
admet-2403	91	16	759	759	NUM
admet-2403	91	17	-	-	SYM
admet-2403	91	18	768	768	NUM
admet-2403	91	19	762	762	NUM
admet-2403	91	20	results	result	NOUN
admet-2403	91	21	and	and	CCONJ
admet-2403	91	22	discussion	discussion	NOUN
admet-2403	91	23	propofol	propofol	NOUN
admet-2403	91	24	solubility	solubility	NOUN
admet-2403	91	25	in	in	ADP
admet-2403	91	26	saline	saline	NOUN
admet-2403	91	27	was	be	AUX
admet-2403	91	28	increased	increase	VERB
admet-2403	91	29	by	by	ADP
admet-2403	91	30	methyl	methyl	NOUN
admet-2403	91	31	-	-	PUNCT
admet-2403	91	32	β	β	NOUN
admet-2403	91	33	-	-	NOUN
admet-2403	91	34	cyclodextrin	cyclodextrin	NOUN
admet-2403	91	35	in	in	ADP
admet-2403	91	36	the	the	DET
admet-2403	91	37	1990s	1990	NOUN
admet-2403	91	38	trapani	trapani	NOUN
admet-2403	91	39	and	and	CCONJ
admet-2403	91	40	co	co	NOUN
admet-2403	91	41	-	-	NOUN
admet-2403	91	42	workers	worker	NOUN
admet-2403	91	43	[	[	X
admet-2403	91	44	26	26	NUM
admet-2403	91	45	]	]	PUNCT
admet-2403	91	46	first	first	ADV
admet-2403	91	47	proposed	propose	VERB
admet-2403	91	48	the	the	DET
admet-2403	91	49	use	use	NOUN
admet-2403	91	50	of	of	ADP
admet-2403	91	51	β	β	NOUN
admet-2403	91	52	-	-	NOUN
admet-2403	91	53	cyclodextrins	cyclodextrin	NOUN
admet-2403	91	54	to	to	PART
admet-2403	91	55	increase	increase	VERB
admet-2403	91	56	the	the	DET
admet-2403	91	57	solubility	solubility	NOUN
admet-2403	91	58	of	of	ADP
admet-2403	91	59	ppf	ppf	PROPN
admet-2403	91	60	in	in	ADP
admet-2403	91	61	water	water	NOUN
admet-2403	91	62	.	.	PUNCT
admet-2403	92	1	hydroxypropyl	hydroxypropyl	NOUN
admet-2403	92	2	-	-	PUNCT
admet-2403	92	3	β	β	NOUN
admet-2403	92	4	-	-	NOUN
admet-2403	92	5	cd	cd	ADJ
admet-2403	92	6	(	(	PUNCT
admet-2403	92	7	hp	hp	PROPN
admet-2403	92	8	-	-	PUNCT
admet-2403	92	9	β	β	NOUN
admet-2403	92	10	-	-	ADJ
admet-2403	92	11	cd	cd	ADJ
admet-2403	92	12	)	)	PUNCT
admet-2403	92	13	concentrations	concentration	NOUN
admet-2403	92	14	in	in	ADP
admet-2403	92	15	the	the	DET
admet-2403	92	16	range	range	NOUN
admet-2403	92	17	of	of	ADP
admet-2403	92	18	4.05	4.05	NUM
admet-2403	92	19	40.5	40.5	NUM
admet-2403	92	20	%	%	NOUN
admet-2403	92	21	(	(	PUNCT
admet-2403	92	22	w	w	NOUN
admet-2403	92	23	/	/	SYM
admet-2403	92	24	v	v	NOUN
admet-2403	92	25	)	)	PUNCT
admet-2403	92	26	increased	increase	VERB
admet-2403	92	27	ppf	ppf	PROPN
admet-2403	92	28	aqueous	aqueous	ADJ
admet-2403	92	29	solubility	solubility	NOUN
admet-2403	92	30	up	up	ADP
admet-2403	92	31	to	to	PART
admet-2403	92	32	250	250	NUM
admet-2403	92	33	folds	fold	NOUN
admet-2403	92	34	[	[	X
admet-2403	92	35	26	26	NUM
admet-2403	92	36	]	]	PUNCT
admet-2403	92	37	.	.	PUNCT
admet-2403	93	1	the	the	DET
admet-2403	93	2	cyclodextrin	cyclodextrin	NOUN
admet-2403	93	3	hollow	hollow	ADJ
admet-2403	93	4	truncated	truncate	VERB
admet-2403	93	5	cone	cone	NOUN
admet-2403	93	6	structure	structure	NOUN
admet-2403	93	7	accommodates	accommodate	VERB
admet-2403	93	8	lipophilic	lipophilic	ADJ
admet-2403	93	9	molecules	molecule	NOUN
admet-2403	93	10	inside	inside	ADP
admet-2403	93	11	the	the	DET
admet-2403	93	12	hydrophobic	hydrophobic	NOUN
admet-2403	93	13	cavity	cavity	NOUN
admet-2403	93	14	.	.	PUNCT
admet-2403	94	1	the	the	DET
admet-2403	94	2	external	external	ADJ
admet-2403	94	3	surface	surface	NOUN
admet-2403	94	4	is	be	AUX
admet-2403	94	5	hydrophilic	hydrophilic	ADJ
admet-2403	94	6	and	and	CCONJ
admet-2403	94	7	provides	provide	VERB
admet-2403	94	8	solubility	solubility	NOUN
admet-2403	94	9	of	of	ADP
admet-2403	94	10	the	the	DET
admet-2403	94	11	complex	complex	NOUN
admet-2403	94	12	in	in	ADP
admet-2403	94	13	water	water	NOUN
admet-2403	94	14	.	.	PUNCT
admet-2403	95	1	later	later	ADV
admet-2403	95	2	,	,	PUNCT
admet-2403	95	3	the	the	DET
admet-2403	95	4	solubilizing	solubilize	VERB
admet-2403	95	5	action	action	NOUN
admet-2403	95	6	of	of	ADP
admet-2403	95	7	sulfobutylether	sulfobutylether	PROPN
admet-2403	95	8	7‐β‐cyclodextrin	7‐β‐cyclodextrin	NUM
admet-2403	95	9	(	(	PUNCT
admet-2403	95	10	sbe	sbe	NOUN
admet-2403	95	11	-	-	PUNCT
admet-2403	95	12	cd	cd	NOUN
admet-2403	95	13	)	)	PUNCT
admet-2403	95	14	was	be	AUX
admet-2403	95	15	exploited	exploit	VERB
admet-2403	95	16	,	,	PUNCT
admet-2403	95	17	yielding	yield	VERB
admet-2403	95	18	,	,	PUNCT
admet-2403	95	19	after	after	ADP
admet-2403	95	20	compounding	compounding	NOUN
admet-2403	95	21	and	and	CCONJ
admet-2403	95	22	lyophilization	lyophilization	NOUN
admet-2403	95	23	,	,	PUNCT
admet-2403	95	24	a	a	DET
admet-2403	95	25	product	product	NOUN
admet-2403	95	26	with	with	ADP
admet-2403	95	27	ppf	ppf	PROPN
admet-2403	95	28	concentration	concentration	NOUN
admet-2403	95	29	of	of	ADP
admet-2403	95	30	10	10	NUM
admet-2403	95	31	mg	mg	NOUN
admet-2403	95	32	/	/	SYM
admet-2403	95	33	ml	ml	NOUN
admet-2403	96	1	[	[	X
admet-2403	96	2	27	27	NUM
admet-2403	96	3	]	]	PUNCT
admet-2403	96	4	.	.	PUNCT
admet-2403	97	1	very	very	ADV
admet-2403	97	2	recently	recently	ADV
admet-2403	97	3	,	,	PUNCT
admet-2403	97	4	the	the	DET
admet-2403	97	5	interaction	interaction	NOUN
admet-2403	97	6	of	of	ADP
admet-2403	97	7	ppf	ppf	PROPN
admet-2403	97	8	with	with	ADP
admet-2403	97	9	hp	hp	PROPN
admet-2403	97	10	-	-	PUNCT
admet-2403	97	11	β	β	NOUN
admet-2403	97	12	-	-	NOUN
admet-2403	97	13	cd	cd	NOUN
admet-2403	97	14	has	have	AUX
admet-2403	97	15	been	be	AUX
admet-2403	97	16	described	describe	VERB
admet-2403	97	17	by	by	ADP
admet-2403	97	18	molecular	molecular	ADJ
admet-2403	97	19	modelling	modelling	NOUN
admet-2403	97	20	[	[	X
admet-2403	97	21	2	2	NUM
admet-2403	97	22	]	]	PUNCT
admet-2403	97	23	.	.	PUNCT
admet-2403	98	1	all	all	DET
admet-2403	98	2	this	this	DET
admet-2403	98	3	research	research	NOUN
admet-2403	98	4	shared	share	VERB
admet-2403	98	5	the	the	DET
admet-2403	98	6	goal	goal	NOUN
admet-2403	98	7	of	of	ADP
admet-2403	98	8	increasing	increase	VERB
admet-2403	98	9	propofol	propofol	ADJ
admet-2403	98	10	solubility	solubility	NOUN
admet-2403	98	11	in	in	ADP
admet-2403	98	12	water	water	NOUN
admet-2403	98	13	to	to	PART
admet-2403	98	14	develop	develop	VERB
admet-2403	98	15	aqueous	aqueous	ADJ
admet-2403	98	16	-	-	PUNCT
admet-2403	98	17	based	base	VERB
admet-2403	98	18	injectable	injectable	ADJ
admet-2403	98	19	formulations	formulation	NOUN
admet-2403	98	20	,	,	PUNCT
admet-2403	98	21	possibly	possibly	ADV
admet-2403	98	22	reducing	reduce	VERB
admet-2403	98	23	the	the	DET
admet-2403	98	24	cited	cite	VERB
admet-2403	98	25	drawbacks	drawback	NOUN
admet-2403	98	26	of	of	ADP
admet-2403	98	27	lipid	lipid	NOUN
admet-2403	98	28	-	-	PUNCT
admet-2403	98	29	based	base	VERB
admet-2403	98	30	formulations	formulation	NOUN
admet-2403	98	31	.	.	PUNCT
admet-2403	99	1	hp	hp	PROPN
admet-2403	99	2	-	-	PUNCT
admet-2403	99	3	β	β	NOUN
admet-2403	99	4	-	-	NOUN
admet-2403	99	5	cd	cd	ADJ
admet-2403	99	6	and	and	CCONJ
admet-2403	99	7	sbe	sbe	PROPN
admet-2403	99	8	-	-	PROPN
admet-2403	99	9	cd	cd	PROPN
admet-2403	99	10	are	be	AUX
admet-2403	99	11	the	the	DET
admet-2403	99	12	most	most	ADV
admet-2403	99	13	extensively	extensively	ADV
admet-2403	99	14	used	use	VERB
admet-2403	99	15	cd	cd	NOUN
admet-2403	99	16	derivatives	derivative	NOUN
admet-2403	99	17	in	in	ADP
admet-2403	99	18	marketed	market	VERB
admet-2403	99	19	products	product	NOUN
admet-2403	99	20	for	for	ADP
admet-2403	99	21	all	all	DET
admet-2403	99	22	administration	administration	NOUN
admet-2403	99	23	routes	route	NOUN
admet-2403	99	24	except	except	SCONJ
admet-2403	99	25	nasal	nasal	NOUN
admet-2403	99	26	[	[	X
admet-2403	99	27	28	28	NUM
admet-2403	99	28	]	]	PUNCT
admet-2403	99	29	.	.	PUNCT
admet-2403	100	1	as	as	SCONJ
admet-2403	100	2	this	this	DET
admet-2403	100	3	study	study	NOUN
admet-2403	100	4	focused	focus	VERB
admet-2403	100	5	on	on	ADP
admet-2403	100	6	ppf	ppf	PROPN
admet-2403	100	7	nasal	nasal	PROPN
admet-2403	100	8	administration	administration	PROPN
admet-2403	100	9	,	,	PUNCT
admet-2403	100	10	we	we	PRON
admet-2403	100	11	selected	select	VERB
admet-2403	100	12	methyl	methyl	NOUN
admet-2403	100	13	-	-	PUNCT
admet-2403	100	14	β	β	NOUN
admet-2403	100	15	-	-	NOUN
admet-2403	100	16	cd	cd	ADJ
admet-2403	100	17	(	(	PUNCT
admet-2403	100	18	meβ	meβ	PROPN
admet-2403	100	19	-	-	PUNCT
admet-2403	100	20	cd	cd	NOUN
admet-2403	100	21	)	)	PUNCT
admet-2403	100	22	because	because	SCONJ
admet-2403	100	23	it	it	PRON
admet-2403	100	24	was	be	AUX
admet-2403	100	25	used	use	VERB
admet-2403	100	26	in	in	ADP
admet-2403	100	27	an	an	DET
admet-2403	100	28	estradiol	estradiol	NOUN
admet-2403	100	29	-	-	PUNCT
admet-2403	100	30	containing	contain	VERB
admet-2403	100	31	marketed	market	VERB
admet-2403	100	32	liquid	liquid	ADJ
admet-2403	100	33	nasal	nasal	NOUN
admet-2403	100	34	spray	spray	NOUN
admet-2403	100	35	,	,	PUNCT
admet-2403	100	36	currently	currently	ADV
admet-2403	100	37	discontinued	discontinue	VERB
admet-2403	100	38	(	(	PUNCT
admet-2403	100	39	aerodiol	aerodiol	PROPN
admet-2403	100	40	®	®	PROPN
admet-2403	100	41	,	,	PUNCT
admet-2403	100	42	laboratoires	laboratoire	VERB
admet-2403	100	43	servier	servier	NOUN
admet-2403	100	44	,	,	PUNCT
admet-2403	100	45	suresnes	suresne	NOUN
admet-2403	100	46	,	,	PUNCT
admet-2403	100	47	france	france	PROPN
admet-2403	100	48	)	)	PUNCT
admet-2403	100	49	.	.	PUNCT
admet-2403	101	1	moreover	moreover	ADV
admet-2403	101	2	,	,	PUNCT
admet-2403	101	3	the	the	DET
admet-2403	101	4	analgesic	analgesic	ADJ
admet-2403	101	5	carfentanil	carfentanil	NOUN
admet-2403	101	6	complexed	complexe	VERB
admet-2403	101	7	with	with	ADP
admet-2403	101	8	dimethyl	dimethyl	NOUN
admet-2403	101	9	-	-	PUNCT
admet-2403	101	10	βcyclodextrin	βcyclodextrin	NOUN
admet-2403	101	11	was	be	AUX
admet-2403	101	12	absorbed	absorb	VERB
admet-2403	101	13	more	more	ADV
admet-2403	101	14	rapidly	rapidly	ADV
admet-2403	101	15	and	and	CCONJ
admet-2403	101	16	extensively	extensively	ADV
admet-2403	101	17	via	via	ADP
admet-2403	101	18	the	the	DET
admet-2403	101	19	nasal	nasal	PROPN
admet-2403	101	20	route	route	NOUN
admet-2403	101	21	than	than	ADP
admet-2403	101	22	intramuscular	intramuscular	ADJ
admet-2403	101	23	injection	injection	NOUN
admet-2403	101	24	or	or	CCONJ
admet-2403	101	25	oral	oral	ADJ
admet-2403	101	26	administration	administration	NOUN
admet-2403	101	27	[	[	X
admet-2403	101	28	29	29	NUM
admet-2403	101	29	]	]	PUNCT
admet-2403	101	30	.	.	PUNCT
admet-2403	102	1	about	about	ADV
admet-2403	102	2	2	2	NUM
admet-2403	102	3	to	to	PART
admet-2403	102	4	5	5	NUM
admet-2403	102	5	%	%	NOUN
admet-2403	102	6	concentrations	concentration	NOUN
admet-2403	102	7	of	of	ADP
admet-2403	102	8	me	i	PRON
admet-2403	102	9	-	-	PUNCT
admet-2403	102	10	β	β	NOUN
admet-2403	102	11	-	-	NOUN
admet-2403	102	12	cd	cd	PROPN
admet-2403	102	13	were	be	AUX
admet-2403	102	14	reported	report	VERB
admet-2403	102	15	not	not	PART
admet-2403	102	16	to	to	PART
admet-2403	102	17	damage	damage	VERB
admet-2403	102	18	the	the	DET
admet-2403	102	19	mucosal	mucosal	NOUN
admet-2403	102	20	membrane	membrane	NOUN
admet-2403	102	21	,	,	PUNCT
admet-2403	102	22	whereas	whereas	SCONJ
admet-2403	102	23	irreversible	irreversible	ADJ
admet-2403	102	24	cilia	cilia	NOUN
admet-2403	102	25	-	-	PUNCT
admet-2403	102	26	inhibition	inhibition	NOUN
admet-2403	102	27	was	be	AUX
admet-2403	102	28	observed	observe	VERB
admet-2403	102	29	at	at	ADP
admet-2403	102	30	10	10	NUM
admet-2403	102	31	%	%	NOUN
admet-2403	102	32	me	me	PROPN
admet-2403	102	33	-	-	PUNCT
admet-2403	102	34	β	β	NOUN
admet-2403	102	35	-	-	NOUN
admet-2403	102	36	cd	cd	NOUN
admet-2403	102	37	[	[	X
admet-2403	102	38	30	30	NUM
admet-2403	102	39	]	]	PUNCT
admet-2403	102	40	.	.	PUNCT
admet-2403	103	1	me	i	PRON
admet-2403	103	2	-	-	PUNCT
admet-2403	103	3	β	β	NOUN
admet-2403	103	4	-	-	ADJ
admet-2403	103	5	cd	cd	ADJ
admet-2403	103	6	works	work	NOUN
admet-2403	103	7	as	as	ADP
admet-2403	103	8	a	a	DET
admet-2403	103	9	solubilizer	solubilizer	NOUN
admet-2403	103	10	and	and	CCONJ
admet-2403	103	11	may	may	AUX
admet-2403	103	12	directly	directly	ADV
admet-2403	103	13	act	act	VERB
admet-2403	103	14	on	on	ADP
admet-2403	103	15	cell	cell	NOUN
admet-2403	103	16	membranes	membrane	NOUN
admet-2403	103	17	,	,	PUNCT
admet-2403	103	18	ultimately	ultimately	ADV
admet-2403	103	19	enhancing	enhance	VERB
admet-2403	103	20	the	the	DET
admet-2403	103	21	drug	drug	NOUN
admet-2403	103	22	transmucosal	transmucosal	NOUN
admet-2403	103	23	permeability	permeability	NOUN
admet-2403	104	1	[	[	X
admet-2403	104	2	31	31	NUM
admet-2403	104	3	]	]	PUNCT
admet-2403	104	4	.	.	PUNCT
admet-2403	105	1	figure	figure	NOUN
admet-2403	105	2	1	1	NUM
admet-2403	105	3	.	.	NOUN
admet-2403	105	4	phase	phase	NOUN
admet-2403	105	5	solubility	solubility	NOUN
admet-2403	105	6	diagram	diagram	NOUN
admet-2403	105	7	of	of	ADP
admet-2403	105	8	propofol	propofol	NOUN
admet-2403	105	9	in	in	ADP
admet-2403	105	10	0.9	0.9	NUM
admet-2403	105	11	%	%	NOUN
admet-2403	105	12	(	(	PUNCT
admet-2403	105	13	w	w	NOUN
admet-2403	105	14	/	/	SYM
admet-2403	105	15	v	v	NOUN
admet-2403	105	16	)	)	PUNCT
admet-2403	105	17	nacl	nacl	ADJ
admet-2403	105	18	saline	saline	NOUN
admet-2403	105	19	solution	solution	NOUN
admet-2403	105	20	as	as	ADP
admet-2403	105	21	a	a	DET
admet-2403	105	22	function	function	NOUN
admet-2403	105	23	of	of	ADP
admet-2403	105	24	methyl	methyl	NOUN
admet-2403	105	25	-	-	PUNCT
admet-2403	105	26	β	β	NOUN
admet-2403	105	27	-	-	PUNCT
admet-2403	105	28	cyclodextrin	cyclodextrin	NOUN
admet-2403	105	29	concentration	concentration	NOUN
admet-2403	105	30	at	at	ADP
admet-2403	105	31	room	room	NOUN
admet-2403	105	32	temperature	temperature	NOUN
admet-2403	105	33	(	(	PUNCT
admet-2403	105	34	≤25	≤25	INTJ
admet-2403	105	35	°	°	NOUN
admet-2403	105	36	c	c	NOUN
admet-2403	105	37	)	)	PUNCT
admet-2403	105	38	.	.	PUNCT
admet-2403	106	1	data	datum	NOUN
admet-2403	106	2	are	be	AUX
admet-2403	106	3	reported	report	VERB
admet-2403	106	4	as	as	ADP
admet-2403	106	5	mean	mean	NOUN
admet-2403	106	6			PROPN
admet-2403	106	7	sd	sd	ADP
admet-2403	106	8	(	(	PUNCT
admet-2403	106	9	n=3	n=3	NOUN
admet-2403	106	10	)	)	PUNCT
admet-2403	106	11	.	.	PUNCT
admet-2403	107	1	figure	figure	NOUN
admet-2403	107	2	1	1	NUM
admet-2403	107	3	shows	show	VERB
admet-2403	107	4	the	the	DET
admet-2403	107	5	phase	phase	NOUN
admet-2403	107	6	solubility	solubility	NOUN
admet-2403	107	7	diagram	diagram	NOUN
admet-2403	107	8	of	of	ADP
admet-2403	107	9	ppf	ppf	PROPN
admet-2403	107	10	as	as	ADP
admet-2403	107	11	a	a	DET
admet-2403	107	12	function	function	NOUN
admet-2403	107	13	of	of	ADP
admet-2403	107	14	me	i	PRON
admet-2403	107	15	-	-	PUNCT
admet-2403	107	16	β	β	NOUN
admet-2403	107	17	-	-	ADJ
admet-2403	107	18	cd	cd	ADJ
admet-2403	107	19	concentration	concentration	NOUN
admet-2403	107	20	.	.	PUNCT
admet-2403	108	1	the	the	DET
admet-2403	108	2	solvent	solvent	NOUN
admet-2403	108	3	of	of	ADP
admet-2403	108	4	the	the	DET
admet-2403	108	5	me	me	PROPN
admet-2403	108	6	-	-	PUNCT
admet-2403	108	7	β	β	NOUN
admet-2403	108	8	-	-	ADJ
admet-2403	108	9	cd	cd	ADJ
admet-2403	108	10	solutions	solution	NOUN
admet-2403	108	11	was	be	AUX
admet-2403	108	12	saline	saline	ADJ
admet-2403	108	13	,	,	PUNCT
admet-2403	108	14	not	not	PART
admet-2403	108	15	water	water	NOUN
admet-2403	108	16	,	,	PUNCT
admet-2403	108	17	because	because	SCONJ
admet-2403	108	18	of	of	ADP
admet-2403	108	19	its	its	PRON
admet-2403	108	20	suitable	suitable	ADJ
admet-2403	108	21	tonicity	tonicity	NOUN
admet-2403	108	22	for	for	ADP
admet-2403	108	23	the	the	DET
admet-2403	108	24	subsequent	subsequent	ADJ
admet-2403	108	25	permeation	permeation	NOUN
admet-2403	108	26	experiments	experiment	NOUN
admet-2403	108	27	with	with	ADP
admet-2403	108	28	the	the	DET
admet-2403	108	29	biological	biological	ADJ
admet-2403	108	30	membrane	membrane	NOUN
admet-2403	108	31	.	.	PUNCT
admet-2403	109	1	me	i	PRON
admet-2403	109	2	-	-	PUNCT
admet-2403	109	3	β	β	NOUN
admet-2403	109	4	-	-	ADJ
admet-2403	109	5	cd	cd	NOUN
admet-2403	109	6	increased	increase	VERB
admet-2403	109	7	the	the	DET
admet-2403	109	8	solubility	solubility	NOUN
admet-2403	109	9	of	of	ADP
admet-2403	109	10	ppf	ppf	PROPN
admet-2403	109	11	in	in	ADP
admet-2403	109	12	saline	saline	NOUN
admet-2403	109	13	by	by	ADP
admet-2403	109	14	about	about	ADV
admet-2403	109	15	5.5	5.5	NUM
admet-2403	109	16	folds	fold	NOUN
admet-2403	109	17	across	across	ADP
admet-2403	109	18	the	the	DET
admet-2403	109	19	considered	consider	VERB
admet-2403	109	20	concentration	concentration	NOUN
admet-2403	109	21	range	range	NOUN
admet-2403	109	22	(	(	PUNCT
admet-2403	109	23	from	from	ADP
admet-2403	109	24	0.263	0.263	NUM
admet-2403	109	25	to	to	ADP
admet-2403	109	26	1.463	1.463	NUM
admet-2403	109	27	mg	mg	PROPN
admet-2403	109	28	/	/	SYM
admet-2403	109	29	ml	ml	NOUN
admet-2403	109	30	)	)	PUNCT
admet-2403	109	31	.	.	PUNCT
admet-2403	110	1	the	the	DET
admet-2403	110	2	me	me	PROPN
admet-2403	110	3	-	-	PUNCT
admet-2403	110	4	β	β	NOUN
admet-2403	110	5	-	-	ADJ
admet-2403	110	6	cd	cd	ADJ
admet-2403	110	7	concentrations	concentration	NOUN
admet-2403	110	8	used	use	VERB
admet-2403	110	9	were	be	AUX
admet-2403	110	10	deliberately	deliberately	ADV
admet-2403	110	11	low	low	ADJ
admet-2403	110	12	and	and	CCONJ
admet-2403	110	13	in	in	ADP
admet-2403	110	14	a	a	DET
admet-2403	110	15	narrow	narrow	ADJ
admet-2403	110	16	range	range	NOUN
admet-2403	110	17	to	to	PART
admet-2403	110	18	remain	remain	VERB
admet-2403	110	19	below	below	ADP
admet-2403	110	20	the	the	DET
admet-2403	110	21	5	5	NUM
admet-2403	110	22	%	%	NOUN
admet-2403	110	23	concentration	concentration	NOUN
admet-2403	110	24	limit	limit	NOUN
admet-2403	110	25	to	to	PART
admet-2403	110	26	avoid	avoid	VERB
admet-2403	110	27	mucosal	mucosal	ADJ
admet-2403	110	28	damage	damage	NOUN
admet-2403	110	29	.	.	PUNCT
admet-2403	111	1	the	the	DET
admet-2403	111	2	lowest	low	ADJ
admet-2403	111	3	cyclodextrin	cyclodextrin	NOUN
admet-2403	111	4	concentration	concentration	NOUN
admet-2403	111	5	of	of	ADP
admet-2403	111	6	the	the	DET
admet-2403	111	7	range	range	NOUN
admet-2403	111	8	was	be	AUX
admet-2403	111	9	too	too	ADV
admet-2403	111	10	small	small	ADJ
admet-2403	111	11	to	to	PART
admet-2403	111	12	exert	exert	VERB
admet-2403	111	13	an	an	DET
admet-2403	111	14	effect	effect	NOUN
admet-2403	111	15	on	on	ADP
admet-2403	111	16	ppf	ppf	PROPN
admet-2403	111	17	solubility	solubility	PROPN
admet-2403	111	18	.	.	PUNCT
admet-2403	112	1	the	the	DET
admet-2403	112	2	fair	fair	ADJ
admet-2403	112	3	linearity	linearity	NOUN
admet-2403	112	4	of	of	ADP
admet-2403	112	5	the	the	DET
admet-2403	112	6	diagram	diagram	NOUN
admet-2403	112	7	(	(	PUNCT
admet-2403	112	8	r2	r2	PROPN
admet-2403	112	9	=	=	SYM
admet-2403	112	10	0.9045	0.9045	NUM
admet-2403	112	11	)	)	PUNCT
admet-2403	112	12	indicates	indicate	VERB
admet-2403	112	13	that	that	SCONJ
admet-2403	112	14	a	a	DET
admet-2403	112	15	1:1	1:1	NUM
admet-2403	112	16	inclusion	inclusion	NOUN
admet-2403	112	17	complex	complex	NOUN
admet-2403	112	18	was	be	AUX
admet-2403	112	19	formed	form	VERB
admet-2403	112	20	.	.	PUNCT
admet-2403	113	1	the	the	DET
admet-2403	113	2	calculated	calculate	VERB
admet-2403	113	3	affinity	affinity	NOUN
admet-2403	113	4	k1:1	k1:1	PROPN
admet-2403	113	5	constant	constant	ADJ
admet-2403	113	6	was	be	AUX
admet-2403	113	7	278.53	278.53	NUM
admet-2403	113	8	m-1	m-1	NOUN
admet-2403	113	9	.	.	PUNCT
admet-2403	114	1	the	the	DET
admet-2403	114	2	inclusion	inclusion	NOUN
admet-2403	114	3	complex	complex	NOUN
admet-2403	114	4	was	be	AUX
admet-2403	114	5	not	not	PART
admet-2403	114	6	isolated	isolate	VERB
admet-2403	114	7	for	for	ADP
admet-2403	114	8	further	further	ADJ
admet-2403	114	9	characterization	characterization	NOUN
admet-2403	114	10	.	.	PUNCT
admet-2403	115	1	nevertheless	nevertheless	ADV
admet-2403	115	2	,	,	PUNCT
admet-2403	115	3	me	i	PRON
admet-2403	115	4	-	-	PUNCT
admet-2403	115	5	β	β	NOUN
admet-2403	115	6	-	-	NOUN
admet-2403	115	7	cd	cd	NOUN
admet-2403	115	8	usefully	usefully	ADV
admet-2403	115	9	improved	improve	VERB
admet-2403	115	10	the	the	DET
admet-2403	115	11	aqueous	aqueous	ADJ
admet-2403	115	12	solubility	solubility	NOUN
admet-2403	115	13	of	of	ADP
admet-2403	115	14	propofol	propofol	NOUN
admet-2403	115	15	at	at	ADP
admet-2403	115	16	safe	safe	ADJ
admet-2403	115	17	concentrations	concentration	NOUN
admet-2403	115	18	for	for	ADP
admet-2403	115	19	nasal	nasal	ADJ
admet-2403	115	20	application	application	NOUN
admet-2403	115	21	.	.	PUNCT
admet-2403	116	1	y	y	NOUN
admet-2403	116	2	=	=	PUNCT
admet-2403	117	1	0.2965x	0.2965x	NOUN
admet-2403	117	2	+	+	NUM
admet-2403	117	3	0.8597	0.8597	NUM
admet-2403	117	4	,	,	PUNCT
admet-2403	117	5	r2	r2	PROPN
admet-2403	117	6	=	=	PUNCT
admet-2403	117	7	0.9132	0.9132	NUM
admet-2403	117	8	admet	admet	NOUN
admet-2403	117	9	&	&	CCONJ
admet-2403	117	10	dmpk	dmpk	PROPN
admet-2403	117	11	12(5	12(5	NUM
admet-2403	117	12	)	)	PUNCT
admet-2403	117	13	(	(	PUNCT
admet-2403	117	14	2024	2024	NUM
admet-2403	117	15	)	)	PUNCT
admet-2403	117	16	759	759	NUM
admet-2403	117	17	-	-	SYM
admet-2403	117	18	768	768	NUM
admet-2403	117	19	a	a	DET
admet-2403	117	20	proof	proof	NOUN
admet-2403	117	21	-	-	PUNCT
admet-2403	117	22	of	of	ADP
admet-2403	117	23	-	-	PUNCT
admet-2403	117	24	concept	concept	NOUN
admet-2403	117	25	study	study	NOUN
admet-2403	117	26	for	for	ADP
admet-2403	117	27	outpatient	outpatient	NOUN
admet-2403	117	28	light	light	ADJ
admet-2403	117	29	sedation	sedation	NOUN
admet-2403	117	30	via	via	ADP
admet-2403	117	31	nasal	nasal	PROPN
admet-2403	117	32	route	route	PROPN
admet-2403	117	33	doi	doi	PROPN
admet-2403	117	34	:	:	PUNCT
admet-2403	117	35	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	117	36	763	763	NUM
admet-2403	117	37	propofol	propofol	NOUN
admet-2403	117	38	did	do	AUX
admet-2403	117	39	not	not	PART
admet-2403	117	40	diffuse	diffuse	VERB
admet-2403	117	41	across	across	ADP
admet-2403	117	42	the	the	DET
admet-2403	117	43	excised	excised	ADJ
admet-2403	117	44	mucosa	mucosa	NOUN
admet-2403	117	45	from	from	ADP
admet-2403	117	46	the	the	DET
admet-2403	117	47	commercial	commercial	ADJ
admet-2403	117	48	emulsion	emulsion	NOUN
admet-2403	117	49	as	as	SCONJ
admet-2403	117	50	mentioned	mention	VERB
admet-2403	117	51	,	,	PUNCT
admet-2403	117	52	in	in	ADP
admet-2403	117	53	their	their	PRON
admet-2403	117	54	in	in	ADP
admet-2403	117	55	vivo	vivo	NOUN
admet-2403	117	56	study	study	NOUN
admet-2403	117	57	,	,	PUNCT
admet-2403	117	58	uchegbu	uchegbu	NOUN
admet-2403	117	59	and	and	CCONJ
admet-2403	117	60	co	co	NOUN
admet-2403	117	61	-	-	NOUN
admet-2403	117	62	workers	worker	NOUN
admet-2403	117	63	[	[	X
admet-2403	117	64	20	20	NUM
admet-2403	117	65	]	]	PUNCT
admet-2403	117	66	administered	administer	VERB
admet-2403	117	67	the	the	DET
admet-2403	117	68	injectable	injectable	ADJ
admet-2403	117	69	emulsion	emulsion	NOUN
admet-2403	117	70	intranasally	intranasally	ADV
admet-2403	117	71	without	without	ADP
admet-2403	117	72	seeing	see	VERB
admet-2403	117	73	an	an	DET
admet-2403	117	74	effect	effect	NOUN
admet-2403	117	75	.	.	PUNCT
admet-2403	118	1	thus	thus	ADV
admet-2403	118	2	,	,	PUNCT
admet-2403	118	3	in	in	ADP
admet-2403	118	4	the	the	DET
admet-2403	118	5	first	first	ADJ
admet-2403	118	6	ex	ex	X
admet-2403	118	7	vivo	vivo	NOUN
admet-2403	118	8	permeation	permeation	NOUN
admet-2403	118	9	experiment	experiment	NOUN
admet-2403	118	10	of	of	ADP
admet-2403	118	11	the	the	DET
admet-2403	118	12	present	present	ADJ
admet-2403	118	13	work	work	NOUN
admet-2403	118	14	,	,	PUNCT
admet-2403	118	15	the	the	DET
admet-2403	118	16	propofol	propofol	NOUN
admet-2403	118	17	kabi	kabi	X
admet-2403	118	18	(	(	PUNCT
admet-2403	118	19	ppf	ppf	PROPN
admet-2403	118	20	-	-	PUNCT
admet-2403	118	21	fk	fk	NOUN
admet-2403	118	22	)	)	PUNCT
admet-2403	118	23	emulsion	emulsion	NOUN
admet-2403	118	24	for	for	ADP
admet-2403	118	25	injection	injection	NOUN
admet-2403	118	26	was	be	AUX
admet-2403	118	27	used	use	VERB
admet-2403	118	28	as	as	ADP
admet-2403	118	29	donor	donor	NOUN
admet-2403	118	30	formulation	formulation	NOUN
admet-2403	118	31	(	(	PUNCT
admet-2403	118	32	1	1	NUM
admet-2403	118	33	ml	ml	NOUN
admet-2403	118	34	)	)	PUNCT
admet-2403	118	35	.	.	PUNCT
admet-2403	119	1	it	it	PRON
admet-2403	119	2	was	be	AUX
admet-2403	119	3	found	find	VERB
admet-2403	119	4	that	that	SCONJ
admet-2403	119	5	ppf	ppf	PROPN
admet-2403	119	6	did	do	AUX
admet-2403	119	7	not	not	PART
admet-2403	119	8	permeate	permeate	VERB
admet-2403	119	9	the	the	DET
admet-2403	119	10	nasal	nasal	ADJ
admet-2403	119	11	tissue	tissue	NOUN
admet-2403	119	12	in	in	ADP
admet-2403	119	13	3	3	NUM
admet-2403	119	14	hours	hour	NOUN
admet-2403	119	15	.	.	PUNCT
admet-2403	120	1	it	it	PRON
admet-2403	120	2	was	be	AUX
admet-2403	120	3	never	never	ADV
admet-2403	120	4	detected	detect	VERB
admet-2403	120	5	in	in	ADP
admet-2403	120	6	the	the	DET
admet-2403	120	7	receptor	receptor	NOUN
admet-2403	120	8	compartment	compartment	NOUN
admet-2403	120	9	,	,	PUNCT
admet-2403	120	10	and	and	CCONJ
admet-2403	120	11	the	the	DET
admet-2403	120	12	mass	mass	NOUN
admet-2403	120	13	balance	balance	NOUN
admet-2403	120	14	confirmed	confirm	VERB
admet-2403	120	15	that	that	SCONJ
admet-2403	120	16	100	100	NUM
admet-2403	120	17	%	%	NOUN
admet-2403	120	18	of	of	ADP
admet-2403	120	19	the	the	DET
admet-2403	120	20	loaded	load	VERB
admet-2403	120	21	ppf	ppf	PROPN
admet-2403	120	22	was	be	AUX
admet-2403	120	23	still	still	ADV
admet-2403	120	24	in	in	ADP
admet-2403	120	25	the	the	DET
admet-2403	120	26	donor	donor	NOUN
admet-2403	120	27	.	.	PUNCT
admet-2403	121	1	we	we	PRON
admet-2403	121	2	could	could	AUX
admet-2403	121	3	exclude	exclude	VERB
admet-2403	121	4	that	that	SCONJ
admet-2403	121	5	the	the	DET
admet-2403	121	6	observed	observed	ADJ
admet-2403	121	7	zero	zero	NUM
admet-2403	121	8	diffusion	diffusion	NOUN
admet-2403	121	9	was	be	AUX
admet-2403	121	10	due	due	ADJ
admet-2403	121	11	to	to	ADP
admet-2403	121	12	low	low	ADJ
admet-2403	121	13	ppf	ppf	PROPN
admet-2403	121	14	solubility	solubility	NOUN
admet-2403	121	15	in	in	ADP
admet-2403	121	16	the	the	DET
admet-2403	121	17	receptor	receptor	NOUN
admet-2403	121	18	medium	medium	NOUN
admet-2403	121	19	;	;	PUNCT
admet-2403	121	20	in	in	ADP
admet-2403	121	21	fact	fact	NOUN
admet-2403	121	22	,	,	PUNCT
admet-2403	121	23	a	a	DET
admet-2403	121	24	preliminary	preliminary	ADJ
admet-2403	121	25	transport	transport	NOUN
admet-2403	121	26	experiment	experiment	NOUN
admet-2403	121	27	with	with	ADP
admet-2403	121	28	franz	franz	NOUN
admet-2403	121	29	cells	cell	NOUN
admet-2403	121	30	and	and	CCONJ
admet-2403	121	31	a	a	DET
admet-2403	121	32	regenerated	regenerated	ADJ
admet-2403	121	33	cellulose	cellulose	NOUN
admet-2403	121	34	membrane	membrane	NOUN
admet-2403	121	35	(	(	PUNCT
admet-2403	121	36	12	12	NUM
admet-2403	121	37	-	-	SYM
admet-2403	121	38	14	14	NUM
admet-2403	121	39	kda	kda	NOUN
admet-2403	121	40	mwco	mwco	NOUN
admet-2403	121	41	)	)	PUNCT
admet-2403	121	42	separating	separate	VERB
admet-2403	121	43	the	the	DET
admet-2403	121	44	compartments	compartment	NOUN
admet-2403	121	45	confirmed	confirm	VERB
admet-2403	121	46	that	that	SCONJ
admet-2403	121	47	sink	sink	NOUN
admet-2403	121	48	conditions	condition	NOUN
admet-2403	121	49	were	be	AUX
admet-2403	121	50	respected	respect	VERB
admet-2403	121	51	(	(	PUNCT
admet-2403	121	52	data	datum	NOUN
admet-2403	121	53	not	not	PART
admet-2403	121	54	shown	show	VERB
admet-2403	121	55	)	)	PUNCT
admet-2403	121	56	.	.	PUNCT
admet-2403	122	1	this	this	DET
admet-2403	122	2	result	result	NOUN
admet-2403	122	3	could	could	AUX
admet-2403	122	4	be	be	AUX
admet-2403	122	5	explained	explain	VERB
admet-2403	122	6	by	by	ADP
admet-2403	122	7	the	the	DET
admet-2403	122	8	lipophilic	lipophilic	ADJ
admet-2403	122	9	ppf	ppf	PROPN
admet-2403	122	10	remaining	remain	VERB
admet-2403	122	11	concentrated	concentrate	VERB
admet-2403	122	12	in	in	ADP
admet-2403	122	13	the	the	DET
admet-2403	122	14	emulsion	emulsion	NOUN
admet-2403	122	15	oil	oil	NOUN
admet-2403	122	16	phase	phase	NOUN
admet-2403	122	17	,	,	PUNCT
admet-2403	122	18	with	with	ADP
admet-2403	122	19	negligible	negligible	ADJ
admet-2403	122	20	partition	partition	NOUN
admet-2403	122	21	toward	toward	ADP
admet-2403	122	22	the	the	DET
admet-2403	122	23	external	external	ADJ
admet-2403	122	24	aqueous	aqueous	ADJ
admet-2403	122	25	phase	phase	NOUN
admet-2403	122	26	for	for	ADP
admet-2403	122	27	subsequent	subsequent	ADJ
admet-2403	122	28	transmucosal	transmucosal	NOUN
admet-2403	122	29	diffusion	diffusion	NOUN
admet-2403	122	30	.	.	PUNCT
admet-2403	123	1	in	in	ADP
admet-2403	123	2	this	this	DET
admet-2403	123	3	regard	regard	NOUN
admet-2403	123	4	,	,	PUNCT
admet-2403	123	5	by	by	ADP
admet-2403	123	6	dialyzing	dialyze	VERB
admet-2403	123	7	4	4	NUM
admet-2403	123	8	ml	ml	NOUN
admet-2403	123	9	of	of	ADP
admet-2403	123	10	ppf	ppf	PROPN
admet-2403	123	11	-	-	PUNCT
admet-2403	123	12	fk	fk	PROPN
admet-2403	123	13	in	in	ADP
admet-2403	123	14	a	a	DET
admet-2403	123	15	regenerated	regenerated	ADJ
admet-2403	123	16	cellulose	cellulose	NOUN
admet-2403	123	17	dialysis	dialysis	NOUN
admet-2403	123	18	tube	tube	NOUN
admet-2403	123	19	(	(	PUNCT
admet-2403	123	20	12	12	NUM
admet-2403	123	21	-	-	SYM
admet-2403	123	22	14	14	NUM
admet-2403	123	23	kda	kda	NOUN
admet-2403	123	24	mwco	mwco	NOUN
admet-2403	123	25	)	)	PUNCT
admet-2403	123	26	against	against	ADP
admet-2403	123	27	150	150	NUM
admet-2403	123	28	ml	ml	NOUN
admet-2403	123	29	of	of	ADP
admet-2403	123	30	an	an	DET
admet-2403	123	31	aqueous	aqueous	ADJ
admet-2403	123	32	solution	solution	NOUN
admet-2403	123	33	of	of	ADP
admet-2403	123	34	1	1	NUM
admet-2403	123	35	%	%	NOUN
admet-2403	123	36	hydroxypropyl	hydroxypropyl	NOUN
admet-2403	123	37	-	-	PUNCT
admet-2403	123	38	β	β	NOUN
admet-2403	123	39	-	-	NOUN
admet-2403	123	40	cyclodextrin	cyclodextrin	NOUN
admet-2403	123	41	[	[	X
admet-2403	123	42	26	26	NUM
admet-2403	123	43	]	]	X
admet-2403	123	44	in	in	ADP
admet-2403	123	45	saline	saline	NOUN
admet-2403	123	46	,	,	PUNCT
admet-2403	123	47	we	we	PRON
admet-2403	123	48	verified	verify	VERB
admet-2403	123	49	that	that	SCONJ
admet-2403	123	50	ppf	ppf	PROPN
admet-2403	123	51	was	be	AUX
admet-2403	123	52	released	release	VERB
admet-2403	123	53	very	very	ADV
admet-2403	123	54	slowly	slowly	ADV
admet-2403	123	55	.	.	PUNCT
admet-2403	124	1	ppf	ppf	PROPN
admet-2403	124	2	concentrations	concentration	NOUN
admet-2403	124	3	out	out	ADP
admet-2403	124	4	of	of	ADP
admet-2403	124	5	the	the	DET
admet-2403	124	6	tube	tube	NOUN
admet-2403	124	7	were	be	AUX
admet-2403	124	8	3.7	3.7	NUM
admet-2403	124	9	and	and	CCONJ
admet-2403	124	10	15	15	NUM
admet-2403	124	11	µg	µg	NOUN
admet-2403	124	12	/	/	SYM
admet-2403	124	13	ml	ml	NOUN
admet-2403	124	14	after	after	ADP
admet-2403	124	15	3	3	NUM
admet-2403	124	16	and	and	CCONJ
admet-2403	124	17	24	24	NUM
admet-2403	124	18	hours	hour	NOUN
admet-2403	124	19	,	,	PUNCT
admet-2403	124	20	respectively	respectively	ADV
admet-2403	124	21	.	.	PUNCT
admet-2403	125	1	several	several	ADJ
admet-2403	125	2	authors	author	NOUN
admet-2403	125	3	have	have	AUX
admet-2403	125	4	determined	determine	VERB
admet-2403	125	5	the	the	DET
admet-2403	125	6	concentration	concentration	NOUN
admet-2403	125	7	of	of	ADP
admet-2403	125	8	ppf	ppf	PROPN
admet-2403	125	9	in	in	ADP
admet-2403	125	10	the	the	DET
admet-2403	125	11	aqueous	aqueous	ADJ
admet-2403	125	12	phase	phase	NOUN
admet-2403	125	13	of	of	ADP
admet-2403	125	14	the	the	DET
admet-2403	125	15	emulsion	emulsion	NOUN
admet-2403	125	16	(	(	PUNCT
admet-2403	125	17	called	call	VERB
admet-2403	125	18	“	"	PUNCT
admet-2403	125	19	emulsion	emulsion	NOUN
admet-2403	125	20	-	-	PUNCT
admet-2403	125	21	free	free	ADJ
admet-2403	125	22	ppf	ppf	NOUN
admet-2403	125	23	”	"	PUNCT
admet-2403	125	24	)	)	PUNCT
admet-2403	125	25	,	,	PUNCT
admet-2403	125	26	mostly	mostly	ADV
admet-2403	125	27	by	by	ADP
admet-2403	125	28	dialysis	dialysis	NOUN
admet-2403	125	29	methods	method	NOUN
admet-2403	125	30	over	over	ADP
admet-2403	125	31	24h	24h	NOUN
admet-2403	125	32	,	,	PUNCT
admet-2403	125	33	and	and	CCONJ
admet-2403	125	34	reported	report	VERB
admet-2403	125	35	similar	similar	ADJ
admet-2403	125	36	values	value	NOUN
admet-2403	125	37	in	in	ADP
admet-2403	125	38	the	the	DET
admet-2403	125	39	order	order	NOUN
admet-2403	125	40	of	of	ADP
admet-2403	125	41	10	10	NUM
admet-2403	125	42	-	-	SYM
admet-2403	125	43	17	17	NUM
admet-2403	125	44	µg	µg	NOUN
admet-2403	125	45	/	/	SYM
admet-2403	125	46	ml	ml	NOUN
admet-2403	125	47	,	,	PUNCT
admet-2403	125	48	corresponding	correspond	VERB
admet-2403	125	49	to	to	ADP
admet-2403	125	50	only	only	ADV
admet-2403	125	51	0.1	0.1	NUM
admet-2403	125	52	%	%	NOUN
admet-2403	125	53	of	of	ADP
admet-2403	125	54	the	the	DET
admet-2403	125	55	ppf	ppf	PROPN
admet-2403	125	56	concentration	concentration	NOUN
admet-2403	125	57	in	in	ADP
admet-2403	125	58	the	the	DET
admet-2403	125	59	whole	whole	ADJ
admet-2403	125	60	emulsion	emulsion	NOUN
admet-2403	126	1	[	[	X
admet-2403	126	2	32	32	NUM
admet-2403	126	3	-	-	SYM
admet-2403	126	4	34	34	NUM
admet-2403	126	5	]	]	PUNCT
admet-2403	126	6	.	.	PUNCT
admet-2403	127	1	hence	hence	ADV
admet-2403	127	2	,	,	PUNCT
admet-2403	127	3	when	when	SCONJ
admet-2403	127	4	the	the	DET
admet-2403	127	5	emulsion	emulsion	NOUN
admet-2403	127	6	was	be	AUX
admet-2403	127	7	deposited	deposit	VERB
admet-2403	127	8	on	on	ADP
admet-2403	127	9	the	the	DET
admet-2403	127	10	nasal	nasal	ADJ
admet-2403	127	11	membrane	membrane	NOUN
admet-2403	127	12	,	,	PUNCT
admet-2403	127	13	its	its	PRON
admet-2403	127	14	aqueous	aqueous	ADJ
admet-2403	127	15	phase	phase	NOUN
admet-2403	127	16	with	with	ADP
admet-2403	127	17	such	such	DET
admet-2403	127	18	a	a	DET
admet-2403	127	19	very	very	ADV
admet-2403	127	20	low	low	ADJ
admet-2403	127	21	ppf	ppf	PROPN
admet-2403	127	22	concentration	concentration	NOUN
admet-2403	127	23	mixed	mix	VERB
admet-2403	127	24	with	with	ADP
admet-2403	127	25	mucus	mucus	NOUN
admet-2403	127	26	and	and	CCONJ
admet-2403	127	27	led	lead	VERB
admet-2403	127	28	to	to	ADP
admet-2403	127	29	an	an	DET
admet-2403	127	30	even	even	ADV
admet-2403	127	31	lower	low	ADJ
admet-2403	127	32	ppf	ppf	PROPN
admet-2403	127	33	concentration	concentration	NOUN
admet-2403	127	34	in	in	ADP
admet-2403	127	35	contact	contact	NOUN
admet-2403	127	36	with	with	ADP
admet-2403	127	37	the	the	DET
admet-2403	127	38	mucosa	mucosa	NOUN
admet-2403	127	39	.	.	PUNCT
admet-2403	128	1	in	in	ADP
admet-2403	128	2	addition	addition	NOUN
admet-2403	128	3	,	,	PUNCT
admet-2403	128	4	the	the	DET
admet-2403	128	5	ppf	ppf	PROPN
admet-2403	128	6	partition	partition	NOUN
admet-2403	128	7	did	do	AUX
admet-2403	128	8	not	not	PART
admet-2403	128	9	favor	favor	VERB
admet-2403	128	10	the	the	DET
admet-2403	128	11	aqueous	aqueous	ADJ
admet-2403	128	12	mucus	mucus	NOUN
admet-2403	128	13	,	,	PUNCT
admet-2403	128	14	negatively	negatively	ADV
admet-2403	128	15	affecting	affect	VERB
admet-2403	128	16	the	the	DET
admet-2403	128	17	concentration	concentration	NOUN
admet-2403	128	18	gradient	gradient	NOUN
admet-2403	128	19	across	across	ADP
admet-2403	128	20	the	the	DET
admet-2403	128	21	mucosa	mucosa	NOUN
admet-2403	128	22	and	and	CCONJ
admet-2403	128	23	the	the	DET
admet-2403	128	24	diffusion	diffusion	NOUN
admet-2403	128	25	.	.	PUNCT
admet-2403	129	1	yamakage	yamakage	NOUN
admet-2403	129	2	et	et	PROPN
admet-2403	129	3	al	al	PROPN
admet-2403	129	4	.	.	PUNCT
admet-2403	130	1	[	[	X
admet-2403	130	2	33	33	NUM
admet-2403	130	3	]	]	PUNCT
admet-2403	130	4	also	also	ADV
admet-2403	130	5	reported	report	VERB
admet-2403	130	6	that	that	SCONJ
admet-2403	130	7	the	the	DET
admet-2403	130	8	emulsion	emulsion	NOUN
admet-2403	130	9	-	-	PUNCT
admet-2403	130	10	free	free	ADJ
admet-2403	130	11	ppf	ppf	PROPN
admet-2403	130	12	decreased	decrease	VERB
admet-2403	130	13	upon	upon	SCONJ
admet-2403	130	14	warming	warm	VERB
admet-2403	130	15	the	the	DET
admet-2403	130	16	emulsion	emulsion	NOUN
admet-2403	130	17	from	from	ADP
admet-2403	130	18	20	20	NUM
admet-2403	130	19	to	to	PART
admet-2403	130	20	36	36	NUM
admet-2403	130	21	°	°	NOUN
admet-2403	130	22	c	c	NOUN
admet-2403	130	23	.	.	PUNCT
admet-2403	131	1	as	as	SCONJ
admet-2403	131	2	the	the	DET
admet-2403	131	3	present	present	ADJ
admet-2403	131	4	permeation	permeation	NOUN
admet-2403	131	5	experiments	experiment	NOUN
admet-2403	131	6	were	be	AUX
admet-2403	131	7	conducted	conduct	VERB
admet-2403	131	8	at	at	ADP
admet-2403	131	9	37	37	NUM
admet-2403	131	10	°	°	NOUN
admet-2403	131	11	c	c	NOUN
admet-2403	131	12	,	,	PUNCT
admet-2403	131	13	this	this	DET
admet-2403	131	14	temperature	temperature	NOUN
admet-2403	131	15	could	could	AUX
admet-2403	131	16	have	have	AUX
admet-2403	131	17	further	far	ADV
admet-2403	131	18	reduced	reduce	VERB
admet-2403	131	19	the	the	DET
admet-2403	131	20	concentration	concentration	NOUN
admet-2403	131	21	gradient	gradient	NOUN
admet-2403	131	22	for	for	ADP
admet-2403	131	23	diffusion	diffusion	NOUN
admet-2403	131	24	.	.	PUNCT
admet-2403	132	1	in	in	ADP
admet-2403	132	2	summary	summary	NOUN
admet-2403	132	3	,	,	PUNCT
admet-2403	132	4	the	the	DET
admet-2403	132	5	marketed	market	VERB
admet-2403	132	6	injectable	injectable	ADJ
admet-2403	132	7	emulsion	emulsion	NOUN
admet-2403	132	8	made	make	VERB
admet-2403	132	9	ppf	ppf	PROPN
admet-2403	132	10	not	not	PART
admet-2403	132	11	(	(	PUNCT
admet-2403	132	12	bio)available	bio)available	NOUN
admet-2403	132	13	to	to	PART
admet-2403	132	14	cross	cross	VERB
admet-2403	132	15	the	the	DET
admet-2403	132	16	nasal	nasal	PROPN
admet-2403	132	17	mucosa	mucosa	PROPN
admet-2403	132	18	.	.	PUNCT
admet-2403	133	1	emulsion	emulsion	NOUN
admet-2403	133	2	dilution	dilution	NOUN
admet-2403	133	3	with	with	ADP
admet-2403	133	4	methyl--cyclodextrin	methyl--cyclodextrin	NOUN
admet-2403	133	5	could	could	AUX
admet-2403	133	6	contribute	contribute	VERB
admet-2403	133	7	to	to	ADP
admet-2403	133	8	propofol	propofol	ADJ
admet-2403	133	9	nasal	nasal	ADJ
admet-2403	133	10	permeation	permeation	NOUN
admet-2403	133	11	developing	develop	VERB
admet-2403	133	12	a	a	DET
admet-2403	133	13	new	new	ADJ
admet-2403	133	14	formulation	formulation	NOUN
admet-2403	133	15	for	for	ADP
admet-2403	133	16	the	the	DET
admet-2403	133	17	intranasal	intranasal	ADJ
admet-2403	133	18	administration	administration	NOUN
admet-2403	133	19	of	of	ADP
admet-2403	133	20	ppf	ppf	PROPN
admet-2403	133	21	was	be	AUX
admet-2403	133	22	beyond	beyond	ADP
admet-2403	133	23	the	the	DET
admet-2403	133	24	scope	scope	NOUN
admet-2403	133	25	of	of	ADP
admet-2403	133	26	this	this	DET
admet-2403	133	27	study	study	NOUN
admet-2403	133	28	.	.	PUNCT
admet-2403	134	1	we	we	PRON
admet-2403	134	2	chose	choose	VERB
admet-2403	134	3	to	to	PART
admet-2403	134	4	modify	modify	VERB
admet-2403	134	5	the	the	DET
admet-2403	134	6	commercial	commercial	ADJ
admet-2403	134	7	ppf	ppf	PROPN
admet-2403	134	8	-	-	PUNCT
admet-2403	134	9	fk	fk	NOUN
admet-2403	134	10	emulsion	emulsion	NOUN
admet-2403	134	11	by	by	ADP
admet-2403	134	12	increasing	increase	VERB
admet-2403	134	13	the	the	DET
admet-2403	134	14	volume	volume	NOUN
admet-2403	134	15	of	of	ADP
admet-2403	134	16	the	the	DET
admet-2403	134	17	external	external	ADJ
admet-2403	134	18	aqueous	aqueous	ADJ
admet-2403	134	19	phase	phase	NOUN
admet-2403	134	20	.	.	PUNCT
admet-2403	135	1	this	this	PRON
admet-2403	135	2	could	could	AUX
admet-2403	135	3	facilitate	facilitate	VERB
admet-2403	135	4	the	the	DET
admet-2403	135	5	interaction	interaction	NOUN
admet-2403	135	6	of	of	ADP
admet-2403	135	7	the	the	DET
admet-2403	135	8	emulsion	emulsion	NOUN
admet-2403	135	9	with	with	ADP
admet-2403	135	10	the	the	DET
admet-2403	135	11	mucus	mucus	NOUN
admet-2403	135	12	[	[	X
admet-2403	135	13	35	35	NUM
admet-2403	135	14	]	]	PUNCT
admet-2403	135	15	,	,	PUNCT
admet-2403	135	16	which	which	PRON
admet-2403	135	17	is	be	AUX
admet-2403	135	18	described	describe	VERB
admet-2403	135	19	as	as	ADP
admet-2403	135	20	an	an	DET
admet-2403	135	21	unstirred	unstirred	ADJ
admet-2403	135	22	water	water	NOUN
admet-2403	135	23	layer	layer	NOUN
admet-2403	135	24	(	(	PUNCT
admet-2403	135	25	uwl	uwl	NOUN
admet-2403	135	26	)	)	PUNCT
admet-2403	135	27	at	at	ADP
admet-2403	135	28	the	the	DET
admet-2403	135	29	exterior	exterior	ADJ
admet-2403	135	30	surface	surface	NOUN
admet-2403	135	31	of	of	ADP
admet-2403	135	32	a	a	DET
admet-2403	135	33	lipophilic	lipophilic	ADJ
admet-2403	135	34	membrane	membrane	NOUN
admet-2403	135	35	,	,	PUNCT
admet-2403	135	36	offering	offer	VERB
admet-2403	135	37	resistance	resistance	NOUN
admet-2403	135	38	to	to	ADP
admet-2403	135	39	permeation	permeation	NOUN
admet-2403	135	40	,	,	PUNCT
admet-2403	135	41	especially	especially	ADV
admet-2403	135	42	of	of	ADP
admet-2403	135	43	poorly	poorly	ADV
admet-2403	135	44	soluble	soluble	ADJ
admet-2403	135	45	drugs	drug	NOUN
admet-2403	135	46	[	[	X
admet-2403	135	47	36	36	NUM
admet-2403	135	48	]	]	PUNCT
admet-2403	135	49	.	.	PUNCT
admet-2403	136	1	the	the	DET
admet-2403	136	2	emulsion	emulsion	NOUN
admet-2403	136	3	was	be	AUX
admet-2403	136	4	diluted	dilute	VERB
admet-2403	136	5	5	5	NUM
admet-2403	136	6	folds	fold	NOUN
admet-2403	136	7	as	as	SCONJ
admet-2403	136	8	instructed	instruct	VERB
admet-2403	136	9	in	in	ADP
admet-2403	136	10	the	the	DET
admet-2403	136	11	summary	summary	NOUN
admet-2403	136	12	of	of	ADP
admet-2403	136	13	product	product	NOUN
admet-2403	136	14	characteristics	characteristic	NOUN
admet-2403	136	15	.	.	PUNCT
admet-2403	137	1	the	the	DET
admet-2403	137	2	diluents	diluent	NOUN
admet-2403	137	3	were	be	AUX
admet-2403	137	4	either	either	CCONJ
admet-2403	137	5	saline	saline	ADJ
admet-2403	137	6	solution	solution	NOUN
admet-2403	137	7	alone	alone	ADV
admet-2403	137	8	or	or	CCONJ
admet-2403	137	9	saline	saline	NOUN
admet-2403	137	10	containing	contain	VERB
admet-2403	137	11	2.94	2.94	NUM
admet-2403	137	12	%	%	NOUN
admet-2403	137	13	(	(	PUNCT
admet-2403	137	14	w	w	NOUN
admet-2403	137	15	/	/	SYM
admet-2403	137	16	v	v	NOUN
admet-2403	137	17	)	)	PUNCT
admet-2403	137	18	me	i	PRON
admet-2403	137	19	-	-	PUNCT
admet-2403	137	20	β	β	NOUN
admet-2403	137	21	-	-	NOUN
admet-2403	137	22	cd	cd	ADJ
admet-2403	137	23	,	,	PUNCT
admet-2403	137	24	i.e.	i.e.	X
admet-2403	137	25	,	,	PUNCT
admet-2403	137	26	the	the	DET
admet-2403	137	27	maximum	maximum	ADJ
admet-2403	137	28	cyclodextrin	cyclodextrin	NOUN
admet-2403	137	29	concentration	concentration	NOUN
admet-2403	137	30	considered	consider	VERB
admet-2403	137	31	in	in	ADP
admet-2403	137	32	the	the	DET
admet-2403	137	33	phase	phase	NOUN
admet-2403	137	34	solubility	solubility	NOUN
admet-2403	137	35	study	study	NOUN
admet-2403	137	36	.	.	PUNCT
admet-2403	138	1	prior	prior	ADV
admet-2403	138	2	to	to	ADP
admet-2403	138	3	the	the	DET
admet-2403	138	4	experiment	experiment	NOUN
admet-2403	138	5	,	,	PUNCT
admet-2403	138	6	ppf	ppf	PROPN
admet-2403	138	7	was	be	AUX
admet-2403	138	8	quantified	quantify	VERB
admet-2403	138	9	in	in	ADP
admet-2403	138	10	the	the	DET
admet-2403	138	11	aqueous	aqueous	ADJ
admet-2403	138	12	phase	phase	NOUN
admet-2403	138	13	of	of	ADP
admet-2403	138	14	both	both	DET
admet-2403	138	15	dilutions	dilution	NOUN
admet-2403	138	16	after	after	ADP
admet-2403	138	17	separating	separate	VERB
admet-2403	138	18	the	the	DET
admet-2403	138	19	oil	oil	NOUN
admet-2403	138	20	and	and	CCONJ
admet-2403	138	21	water	water	NOUN
admet-2403	138	22	phases	phase	NOUN
admet-2403	138	23	by	by	ADP
admet-2403	138	24	centrifugation	centrifugation	NOUN
admet-2403	138	25	(	(	PUNCT
admet-2403	138	26	10,000	10,000	NUM
admet-2403	138	27	rpm	rpm	NOUN
admet-2403	138	28	,	,	PUNCT
admet-2403	138	29	20	20	NUM
admet-2403	138	30	min	min	NOUN
admet-2403	138	31	)	)	PUNCT
admet-2403	138	32	.	.	PUNCT
admet-2403	139	1	ppf	ppf	PROPN
admet-2403	139	2	concentrations	concentration	NOUN
admet-2403	139	3	of	of	ADP
admet-2403	139	4	54.9	54.9	NUM
admet-2403	139	5	±	±	NUM
admet-2403	139	6	0.8	0.8	NUM
admet-2403	139	7	µg	µg	NOUN
admet-2403	139	8	/	/	SYM
admet-2403	139	9	ml	ml	NOUN
admet-2403	139	10	and	and	CCONJ
admet-2403	139	11	389.7	389.7	NUM
admet-2403	139	12	±	±	NUM
admet-2403	139	13	3.4	3.4	NUM
admet-2403	139	14	µg	µg	NOUN
admet-2403	139	15	/	/	SYM
admet-2403	139	16	ml	ml	NOUN
admet-2403	139	17	were	be	AUX
admet-2403	139	18	measured	measure	VERB
admet-2403	139	19	,	,	PUNCT
admet-2403	139	20	respectively	respectively	ADV
admet-2403	139	21	without	without	ADP
admet-2403	139	22	and	and	CCONJ
admet-2403	139	23	with	with	ADP
admet-2403	139	24	me	i	PRON
admet-2403	139	25	-	-	PUNCT
admet-2403	139	26	β	β	NOUN
admet-2403	139	27	-	-	NOUN
admet-2403	139	28	cd	cd	NOUN
admet-2403	139	29	.	.	PUNCT
admet-2403	140	1	thus	thus	ADV
admet-2403	140	2	,	,	PUNCT
admet-2403	140	3	the	the	DET
admet-2403	140	4	dilution	dilution	NOUN
admet-2403	140	5	with	with	ADP
admet-2403	140	6	saline	saline	NOUN
admet-2403	140	7	slightly	slightly	ADV
admet-2403	140	8	increased	increase	VERB
admet-2403	140	9	the	the	DET
admet-2403	140	10	“	"	PUNCT
admet-2403	140	11	emulsion	emulsion	NOUN
admet-2403	140	12	-	-	PUNCT
admet-2403	140	13	free	free	ADJ
admet-2403	140	14	”	"	PUNCT
admet-2403	140	15	ppf	ppf	PROPN
admet-2403	140	16	compared	compare	VERB
admet-2403	140	17	to	to	ADP
admet-2403	140	18	the	the	DET
admet-2403	140	19	ppf	ppf	PROPN
admet-2403	140	20	concentration	concentration	NOUN
admet-2403	140	21	determined	determine	VERB
admet-2403	140	22	by	by	ADP
admet-2403	140	23	dialyzing	dialyze	VERB
admet-2403	140	24	the	the	DET
admet-2403	140	25	commercial	commercial	ADJ
admet-2403	140	26	emulsion	emulsion	NOUN
admet-2403	140	27	.	.	PUNCT
admet-2403	141	1	more	more	ADV
admet-2403	141	2	importantly	importantly	ADV
admet-2403	141	3	,	,	PUNCT
admet-2403	141	4	in	in	ADP
admet-2403	141	5	the	the	DET
admet-2403	141	6	dilution	dilution	NOUN
admet-2403	141	7	made	make	VERB
admet-2403	141	8	with	with	ADP
admet-2403	141	9	the	the	DET
admet-2403	141	10	me	me	VERB
admet-2403	141	11	-	-	PUNCT
admet-2403	141	12	β	β	NOUN
admet-2403	141	13	-	-	ADJ
admet-2403	141	14	cd	cd	NOUN
admet-2403	141	15	-	-	PUNCT
admet-2403	141	16	containing	contain	VERB
admet-2403	141	17	saline	saline	NOUN
admet-2403	141	18	,	,	PUNCT
admet-2403	141	19	the	the	DET
admet-2403	141	20	complexation	complexation	NOUN
admet-2403	141	21	of	of	ADP
admet-2403	141	22	propofol	propofol	NOUN
admet-2403	141	23	by	by	ADP
admet-2403	141	24	the	the	DET
admet-2403	141	25	oligosaccharide	oligosaccharide	NOUN
admet-2403	141	26	enabled	enable	VERB
admet-2403	141	27	more	more	ADJ
admet-2403	141	28	drug	drug	NOUN
admet-2403	141	29	to	to	PART
admet-2403	141	30	partition	partition	VERB
admet-2403	141	31	from	from	ADP
admet-2403	141	32	the	the	DET
admet-2403	141	33	oil	oil	NOUN
admet-2403	141	34	to	to	ADP
admet-2403	141	35	the	the	DET
admet-2403	141	36	water	water	NOUN
admet-2403	141	37	phase	phase	NOUN
admet-2403	141	38	.	.	PUNCT
admet-2403	142	1	it	it	PRON
admet-2403	142	2	should	should	AUX
admet-2403	142	3	be	be	AUX
admet-2403	142	4	noted	note	VERB
admet-2403	142	5	that	that	SCONJ
admet-2403	142	6	both	both	CCONJ
admet-2403	142	7	the	the	DET
admet-2403	142	8	above	above	ADJ
admet-2403	142	9	ppf	ppf	PROPN
admet-2403	142	10	concentrations	concentration	NOUN
admet-2403	142	11	were	be	AUX
admet-2403	142	12	lower	low	ADJ
admet-2403	142	13	than	than	ADP
admet-2403	142	14	the	the	DET
admet-2403	142	15	solubility	solubility	NOUN
admet-2403	142	16	values	value	NOUN
admet-2403	142	17	determined	determine	VERB
admet-2403	142	18	at	at	ADP
admet-2403	142	19	0	0	NUM
admet-2403	142	20	and	and	CCONJ
admet-2403	142	21	2.94	2.94	NUM
admet-2403	142	22	%	%	NOUN
admet-2403	142	23	(	(	PUNCT
admet-2403	142	24	w	w	NOUN
admet-2403	142	25	/	/	SYM
admet-2403	142	26	v	v	NOUN
admet-2403	142	27	)	)	PUNCT
admet-2403	142	28	me	i	PRON
admet-2403	142	29	-	-	PUNCT
admet-2403	142	30	β	β	NOUN
admet-2403	142	31	-	-	ADJ
admet-2403	142	32	cd	cd	ADJ
admet-2403	142	33	concentrations	concentration	NOUN
admet-2403	142	34	in	in	ADP
admet-2403	142	35	saline	saline	NOUN
admet-2403	142	36	using	use	VERB
admet-2403	142	37	ppf	ppf	PROPN
admet-2403	142	38	raw	raw	ADJ
admet-2403	142	39	material	material	NOUN
admet-2403	142	40	(	(	PUNCT
admet-2403	142	41	figure	figure	NOUN
admet-2403	142	42	1	1	NUM
admet-2403	142	43	)	)	PUNCT
admet-2403	142	44	.	.	PUNCT
admet-2403	143	1	this	this	DET
admet-2403	143	2	difference	difference	NOUN
admet-2403	143	3	was	be	AUX
admet-2403	143	4	likely	likely	ADV
admet-2403	143	5	caused	cause	VERB
admet-2403	143	6	by	by	ADP
admet-2403	143	7	the	the	DET
admet-2403	143	8	presence	presence	NOUN
admet-2403	143	9	of	of	ADP
admet-2403	143	10	the	the	DET
admet-2403	143	11	oil	oil	NOUN
admet-2403	143	12	phase	phase	NOUN
admet-2403	143	13	in	in	ADP
admet-2403	143	14	the	the	DET
admet-2403	143	15	diluted	diluted	ADJ
admet-2403	143	16	emulsion	emulsion	NOUN
admet-2403	143	17	,	,	PUNCT
admet-2403	143	18	for	for	ADP
admet-2403	143	19	which	which	DET
admet-2403	143	20	propofol	propofol	NOUN
admet-2403	143	21	maintained	maintain	VERB
admet-2403	143	22	the	the	DET
admet-2403	143	23	greatest	great	ADJ
admet-2403	143	24	affinity	affinity	NOUN
admet-2403	143	25	in	in	ADP
admet-2403	143	26	competition	competition	NOUN
admet-2403	143	27	with	with	ADP
admet-2403	143	28	cyclodextrin	cyclodextrin	NOUN
admet-2403	143	29	.	.	PUNCT
admet-2403	144	1	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	144	2	m.	m.	PROPN
admet-2403	144	3	d.	d.	PROPN
admet-2403	144	4	spampinato	spampinato	PROPN
admet-2403	144	5	et	et	PROPN
admet-2403	144	6	al	al	PROPN
admet-2403	144	7	.	.	PROPN
admet-2403	144	8	admet	admet	PROPN
admet-2403	144	9	&	&	CCONJ
admet-2403	144	10	dmpk	dmpk	PROPN
admet-2403	144	11	12(5	12(5	NUM
admet-2403	144	12	)	)	PUNCT
admet-2403	144	13	(	(	PUNCT
admet-2403	144	14	2024	2024	NUM
admet-2403	144	15	)	)	PUNCT
admet-2403	144	16	759	759	NUM
admet-2403	144	17	-	-	SYM
admet-2403	144	18	768	768	NUM
admet-2403	144	19	764	764	NUM
admet-2403	144	20	figure	figure	NOUN
admet-2403	144	21	2	2	NUM
admet-2403	144	22	shows	show	VERB
admet-2403	144	23	the	the	DET
admet-2403	144	24	permeation	permeation	NOUN
admet-2403	144	25	of	of	ADP
admet-2403	144	26	ppf	ppf	PROPN
admet-2403	144	27	from	from	ADP
admet-2403	144	28	the	the	DET
admet-2403	144	29	two	two	NUM
admet-2403	144	30	dilutions	dilution	NOUN
admet-2403	144	31	across	across	ADP
admet-2403	144	32	excised	excise	VERB
admet-2403	144	33	rabbit	rabbit	NOUN
admet-2403	144	34	nasal	nasal	PROPN
admet-2403	144	35	mucosa	mucosa	PROPN
admet-2403	144	36	.	.	PUNCT
admet-2403	145	1	the	the	DET
admet-2403	145	2	dilution	dilution	NOUN
admet-2403	145	3	without	without	ADP
admet-2403	145	4	cyclodextrin	cyclodextrin	NOUN
admet-2403	145	5	led	lead	VERB
admet-2403	145	6	to	to	ADP
admet-2403	145	7	a	a	DET
admet-2403	145	8	very	very	ADV
admet-2403	145	9	small	small	ADJ
admet-2403	145	10	amount	amount	NOUN
admet-2403	145	11	of	of	ADP
admet-2403	145	12	ppf	ppf	PROPN
admet-2403	145	13	permeated	permeate	VERB
admet-2403	145	14	in	in	ADP
admet-2403	145	15	3h	3h	NUM
admet-2403	145	16	(	(	PUNCT
admet-2403	145	17	8.9	8.9	NUM
admet-2403	145	18	±	±	NUM
admet-2403	145	19	1.3	1.3	NUM
admet-2403	145	20	µg	µg	ADP
admet-2403	145	21	cm-2	cm-2	NOUN
admet-2403	145	22	)	)	PUNCT
admet-2403	145	23	,	,	PUNCT
admet-2403	145	24	i.e.	i.e.	X
admet-2403	145	25	,	,	PUNCT
admet-2403	145	26	less	less	ADJ
admet-2403	145	27	than	than	ADP
admet-2403	145	28	0.3	0.3	NUM
admet-2403	145	29	%	%	NOUN
admet-2403	145	30	of	of	ADP
admet-2403	145	31	the	the	DET
admet-2403	145	32	ppf	ppf	PROPN
admet-2403	145	33	initially	initially	ADV
admet-2403	145	34	loaded	load	VERB
admet-2403	145	35	in	in	ADP
admet-2403	145	36	the	the	DET
admet-2403	145	37	donor	donor	NOUN
admet-2403	145	38	.	.	PUNCT
admet-2403	146	1	0.4	0.4	NUM
admet-2403	146	2	%	%	NOUN
admet-2403	146	3	of	of	ADP
admet-2403	146	4	ppf	ppf	PROPN
admet-2403	146	5	was	be	AUX
admet-2403	146	6	extracted	extract	VERB
admet-2403	146	7	from	from	ADP
admet-2403	146	8	the	the	DET
admet-2403	146	9	mucosa	mucosa	NOUN
admet-2403	146	10	,	,	PUNCT
admet-2403	146	11	and	and	CCONJ
admet-2403	146	12	the	the	DET
admet-2403	146	13	rest	rest	NOUN
admet-2403	146	14	was	be	AUX
admet-2403	146	15	recovered	recover	VERB
admet-2403	146	16	from	from	ADP
admet-2403	146	17	the	the	DET
admet-2403	146	18	donor	donor	NOUN
admet-2403	146	19	(	(	PUNCT
admet-2403	146	20	mass	mass	ADJ
admet-2403	146	21	balance	balance	NOUN
admet-2403	146	22	97	97	NUM
admet-2403	146	23	%	%	NOUN
admet-2403	146	24	)	)	PUNCT
admet-2403	146	25	.	.	PUNCT
admet-2403	147	1	the	the	DET
admet-2403	147	2	permeation	permeation	NOUN
admet-2403	147	3	was	be	AUX
admet-2403	147	4	slow	slow	ADJ
admet-2403	147	5	,	,	PUNCT
admet-2403	147	6	with	with	ADP
admet-2403	147	7	a	a	DET
admet-2403	147	8	30	30	NUM
admet-2403	147	9	-	-	PUNCT
admet-2403	147	10	minute	minute	NOUN
admet-2403	147	11	time	time	NOUN
admet-2403	147	12	lag	lag	NOUN
admet-2403	147	13	,	,	PUNCT
admet-2403	147	14	and	and	CCONJ
admet-2403	147	15	quite	quite	ADV
admet-2403	147	16	variable	variable	ADJ
admet-2403	147	17	.	.	PUNCT
admet-2403	148	1	still	still	ADV
admet-2403	148	2	,	,	PUNCT
admet-2403	148	3	some	some	DET
admet-2403	148	4	drug	drug	NOUN
admet-2403	148	5	had	have	AUX
admet-2403	148	6	diffused	diffuse	VERB
admet-2403	148	7	compared	compare	VERB
admet-2403	148	8	to	to	ADP
admet-2403	148	9	the	the	DET
admet-2403	148	10	commercial	commercial	ADJ
admet-2403	148	11	emulsion	emulsion	NOUN
admet-2403	148	12	,	,	PUNCT
admet-2403	148	13	despite	despite	SCONJ
admet-2403	148	14	the	the	DET
admet-2403	148	15	dilution	dilution	NOUN
admet-2403	148	16	causing	cause	VERB
admet-2403	148	17	a	a	DET
admet-2403	148	18	5	5	NUM
admet-2403	148	19	-	-	ADJ
admet-2403	148	20	fold	fold	ADJ
admet-2403	148	21	decrease	decrease	NOUN
admet-2403	148	22	of	of	ADP
admet-2403	148	23	the	the	DET
admet-2403	148	24	total	total	ADJ
admet-2403	148	25	ppf	ppf	PROPN
admet-2403	148	26	concentration	concentration	NOUN
admet-2403	148	27	in	in	ADP
admet-2403	148	28	the	the	DET
admet-2403	148	29	system	system	NOUN
admet-2403	148	30	.	.	PUNCT
admet-2403	149	1	as	as	SCONJ
admet-2403	149	2	measured	measure	VERB
admet-2403	149	3	,	,	PUNCT
admet-2403	149	4	the	the	DET
admet-2403	149	5	dilution	dilution	NOUN
admet-2403	149	6	with	with	ADP
admet-2403	149	7	saline	saline	NOUN
admet-2403	149	8	had	have	AUX
admet-2403	149	9	minimally	minimally	ADV
admet-2403	149	10	increased	increase	VERB
admet-2403	149	11	the	the	DET
admet-2403	149	12	emulsion	emulsion	NOUN
admet-2403	149	13	-	-	PUNCT
admet-2403	149	14	free	free	ADJ
admet-2403	149	15	ppf	ppf	PROPN
admet-2403	149	16	concentration	concentration	NOUN
admet-2403	149	17	,	,	PUNCT
admet-2403	149	18	which	which	PRON
admet-2403	149	19	is	be	AUX
admet-2403	149	20	the	the	DET
admet-2403	149	21	actual	actual	ADJ
admet-2403	149	22	fraction	fraction	NOUN
admet-2403	149	23	of	of	ADP
admet-2403	149	24	the	the	DET
admet-2403	149	25	drug	drug	NOUN
admet-2403	149	26	available	available	ADJ
admet-2403	149	27	for	for	ADP
admet-2403	149	28	diffusion	diffusion	NOUN
admet-2403	149	29	at	at	ADP
admet-2403	149	30	first	first	ADV
admet-2403	149	31	.	.	PUNCT
admet-2403	150	1	figure	figure	VERB
admet-2403	150	2	2	2	NUM
admet-2403	150	3	.	.	PUNCT
admet-2403	150	4	propofol	propofol	NOUN
admet-2403	150	5	transport	transport	NOUN
admet-2403	150	6	across	across	ADP
admet-2403	150	7	excised	excise	VERB
admet-2403	150	8	rabbit	rabbit	NOUN
admet-2403	150	9	nasal	nasal	PROPN
admet-2403	150	10	mucosa	mucosa	PROPN
admet-2403	150	11	from	from	ADP
admet-2403	150	12	1:5	1:5	NUM
admet-2403	150	13	dilutions	dilution	NOUN
admet-2403	150	14	of	of	ADP
admet-2403	150	15	the	the	DET
admet-2403	150	16	ppf	ppf	PROPN
admet-2403	150	17	-	-	PUNCT
admet-2403	150	18	fk	fk	INTJ
admet-2403	150	19	emulsion	emulsion	NOUN
admet-2403	150	20	with	with	ADP
admet-2403	150	21	:	:	PUNCT
admet-2403	150	22	0.9	0.9	NUM
admet-2403	150	23	%	%	NOUN
admet-2403	150	24	nacl	nacl	NOUN
admet-2403	150	25	saline	saline	NOUN
admet-2403	150	26	solution	solution	NOUN
admet-2403	150	27	(	(	PUNCT
admet-2403	150	28	square	square	ADJ
admet-2403	150	29	)	)	PUNCT
admet-2403	150	30	and	and	CCONJ
admet-2403	150	31	saline	saline	ADJ
admet-2403	150	32	solution	solution	NOUN
admet-2403	150	33	containing	contain	VERB
admet-2403	150	34	2.94	2.94	NUM
admet-2403	150	35	%	%	NOUN
admet-2403	150	36	methyl--cyclodextrin	methyl--cyclodextrin	NOUN
admet-2403	150	37	(	(	PUNCT
admet-2403	150	38	circle	circle	PROPN
admet-2403	150	39	)	)	PUNCT
admet-2403	150	40	.	.	PUNCT
admet-2403	151	1	data	datum	NOUN
admet-2403	151	2	are	be	AUX
admet-2403	151	3	reported	report	VERB
admet-2403	151	4	as	as	ADP
admet-2403	151	5	mean	mean	NOUN
admet-2403	151	6			PROPN
admet-2403	151	7	sem	sem	NOUN
admet-2403	151	8	(	(	PUNCT
admet-2403	151	9	n=3	n=3	NOUN
admet-2403	151	10	)	)	PUNCT
admet-2403	151	11	.	.	PUNCT
admet-2403	152	1	when	when	SCONJ
admet-2403	152	2	the	the	DET
admet-2403	152	3	ppf	ppf	PROPN
admet-2403	152	4	-	-	PUNCT
admet-2403	152	5	fk	fk	NOUN
admet-2403	152	6	emulsion	emulsion	NOUN
admet-2403	152	7	was	be	AUX
admet-2403	152	8	diluted	dilute	VERB
admet-2403	152	9	5	5	NUM
admet-2403	152	10	folds	fold	NOUN
admet-2403	152	11	with	with	ADP
admet-2403	152	12	the	the	DET
admet-2403	152	13	2.94	2.94	NUM
admet-2403	152	14	%	%	NOUN
admet-2403	152	15	(	(	PUNCT
admet-2403	152	16	w	w	NOUN
admet-2403	152	17	/	/	SYM
admet-2403	152	18	v	v	NOUN
admet-2403	152	19	)	)	PUNCT
admet-2403	152	20	me	i	PRON
admet-2403	152	21	-	-	PUNCT
admet-2403	152	22	β	β	NOUN
admet-2403	152	23	-	-	ADJ
admet-2403	152	24	cd	cd	ADJ
admet-2403	152	25	solution	solution	NOUN
admet-2403	152	26	in	in	ADP
admet-2403	152	27	saline	saline	NOUN
admet-2403	152	28	,	,	PUNCT
admet-2403	152	29	ppf	ppf	PROPN
admet-2403	152	30	permeation	permeation	NOUN
admet-2403	152	31	across	across	ADP
admet-2403	152	32	the	the	DET
admet-2403	152	33	nasal	nasal	ADJ
admet-2403	152	34	membrane	membrane	NOUN
admet-2403	152	35	increased	increase	VERB
admet-2403	152	36	significantly	significantly	ADV
admet-2403	152	37	.	.	PUNCT
admet-2403	153	1	the	the	DET
admet-2403	153	2	time	time	NOUN
admet-2403	153	3	lag	lag	NOUN
admet-2403	153	4	disappeared	disappear	VERB
admet-2403	153	5	,	,	PUNCT
admet-2403	153	6	signifying	signify	VERB
admet-2403	153	7	that	that	SCONJ
admet-2403	153	8	some	some	DET
admet-2403	153	9	drug	drug	NOUN
admet-2403	153	10	molecules	molecule	NOUN
admet-2403	153	11	were	be	AUX
admet-2403	153	12	immediately	immediately	ADV
admet-2403	153	13	ready	ready	ADJ
admet-2403	153	14	to	to	PART
admet-2403	153	15	cross	cross	VERB
admet-2403	153	16	the	the	DET
admet-2403	153	17	tissue	tissue	NOUN
admet-2403	153	18	and	and	CCONJ
admet-2403	153	19	diffuse	diffuse	NOUN
admet-2403	153	20	.	.	PUNCT
admet-2403	154	1	the	the	DET
admet-2403	154	2	linearity	linearity	NOUN
admet-2403	154	3	of	of	ADP
admet-2403	154	4	the	the	DET
admet-2403	154	5	profile	profile	NOUN
admet-2403	154	6	witnessed	witness	VERB
admet-2403	154	7	the	the	DET
admet-2403	154	8	early	early	ADJ
admet-2403	154	9	establishment	establishment	NOUN
admet-2403	154	10	of	of	ADP
admet-2403	154	11	steady	steady	ADJ
admet-2403	154	12	-	-	PUNCT
admet-2403	154	13	state	state	NOUN
admet-2403	154	14	conditions	condition	NOUN
admet-2403	154	15	maintained	maintain	VERB
admet-2403	154	16	till	till	SCONJ
admet-2403	154	17	the	the	DET
admet-2403	154	18	end	end	NOUN
admet-2403	154	19	of	of	ADP
admet-2403	154	20	the	the	DET
admet-2403	154	21	test	test	NOUN
admet-2403	154	22	.	.	PUNCT
admet-2403	155	1	the	the	DET
admet-2403	155	2	resulting	result	VERB
admet-2403	155	3	steady	steady	ADJ
admet-2403	155	4	-	-	PUNCT
admet-2403	155	5	state	state	NOUN
admet-2403	155	6	flux	flux	NOUN
admet-2403	155	7	was	be	AUX
admet-2403	155	8	0.41	0.41	NUM
admet-2403	155	9	±	±	NUM
admet-2403	155	10	0.03	0.03	NUM
admet-2403	155	11	µg	µg	ADV
admet-2403	155	12	cm-2	cm-2	VERB
admet-2403	155	13	min-1	min-1	X
admet-2403	155	14	.	.	PROPN
admet-2403	155	15	2.1	2.1	NUM
admet-2403	155	16	%	%	NOUN
admet-2403	155	17	of	of	ADP
admet-2403	155	18	the	the	DET
admet-2403	155	19	loaded	load	VERB
admet-2403	155	20	ppf	ppf	PROPN
admet-2403	155	21	diffused	diffuse	VERB
admet-2403	155	22	into	into	ADP
admet-2403	155	23	the	the	DET
admet-2403	155	24	receptor	receptor	NOUN
admet-2403	155	25	compartment	compartment	NOUN
admet-2403	155	26	in	in	ADP
admet-2403	155	27	3	3	NUM
admet-2403	155	28	h	h	NOUN
admet-2403	155	29	,	,	PUNCT
admet-2403	155	30	corresponding	correspond	VERB
admet-2403	155	31	to	to	ADP
admet-2403	155	32	73.4	73.4	NUM
admet-2403	155	33	±	±	NUM
admet-2403	155	34	4.1	4.1	NUM
admet-2403	155	35	µg	µg	NOUN
admet-2403	155	36	cm-2	cm-2	NOUN
admet-2403	155	37	of	of	ADP
admet-2403	155	38	ppf	ppf	PROPN
admet-2403	155	39	.	.	PUNCT
admet-2403	156	1	on	on	ADP
admet-2403	156	2	the	the	DET
admet-2403	156	3	one	one	NUM
admet-2403	156	4	hand	hand	NOUN
admet-2403	156	5	,	,	PUNCT
admet-2403	156	6	this	this	DET
admet-2403	156	7	result	result	NOUN
admet-2403	156	8	was	be	AUX
admet-2403	156	9	reasonably	reasonably	ADV
admet-2403	156	10	driven	drive	VERB
admet-2403	156	11	by	by	ADP
admet-2403	156	12	ppf	ppf	PROPN
admet-2403	156	13	complexation	complexation	NOUN
admet-2403	156	14	by	by	ADP
admet-2403	156	15	me	i	PRON
admet-2403	156	16	-	-	PUNCT
admet-2403	156	17	β	β	NOUN
admet-2403	156	18	-	-	NOUN
admet-2403	156	19	cd	cd	NOUN
admet-2403	156	20	.	.	PUNCT
admet-2403	157	1	despite	despite	SCONJ
admet-2403	157	2	the	the	DET
admet-2403	157	3	complexation	complexation	NOUN
admet-2403	157	4	that	that	PRON
admet-2403	157	5	may	may	AUX
admet-2403	157	6	determine	determine	VERB
admet-2403	157	7	a	a	DET
admet-2403	157	8	low	low	ADJ
admet-2403	157	9	concentration	concentration	NOUN
admet-2403	157	10	of	of	ADP
admet-2403	157	11	free	free	ADJ
admet-2403	157	12	unbound	unbound	NOUN
admet-2403	157	13	drug	drug	NOUN
admet-2403	157	14	in	in	ADP
admet-2403	157	15	solution	solution	NOUN
admet-2403	157	16	,	,	PUNCT
admet-2403	157	17	a	a	DET
admet-2403	157	18	greater	great	ADJ
admet-2403	157	19	amount	amount	NOUN
admet-2403	157	20	of	of	ADP
admet-2403	157	21	drug	drug	NOUN
admet-2403	157	22	dispersed	disperse	VERB
admet-2403	157	23	at	at	ADP
admet-2403	157	24	the	the	DET
admet-2403	157	25	molecular	molecular	ADJ
admet-2403	157	26	level	level	NOUN
admet-2403	157	27	,	,	PUNCT
admet-2403	157	28	either	either	CCONJ
admet-2403	157	29	bound	bind	VERB
admet-2403	157	30	or	or	CCONJ
admet-2403	157	31	unbound	unbound	NOUN
admet-2403	157	32	,	,	PUNCT
admet-2403	157	33	justifies	justify	VERB
admet-2403	157	34	the	the	DET
admet-2403	157	35	higher	high	ADJ
admet-2403	157	36	solubility	solubility	NOUN
admet-2403	157	37	in	in	ADP
admet-2403	157	38	the	the	DET
admet-2403	157	39	aqueous	aqueous	ADJ
admet-2403	157	40	phase	phase	NOUN
admet-2403	157	41	.	.	PUNCT
admet-2403	158	1	as	as	SCONJ
admet-2403	158	2	discussed	discuss	VERB
admet-2403	158	3	,	,	PUNCT
admet-2403	158	4	this	this	DET
admet-2403	158	5	solubilizing	solubilize	VERB
admet-2403	158	6	effect	effect	NOUN
admet-2403	158	7	by	by	ADP
admet-2403	158	8	cyclodextrin	cyclodextrin	NOUN
admet-2403	158	9	shifted	shift	VERB
admet-2403	158	10	the	the	DET
admet-2403	158	11	ppf	ppf	PROPN
admet-2403	158	12	partition	partition	NOUN
admet-2403	158	13	equilibrium	equilibrium	NOUN
admet-2403	158	14	between	between	ADP
admet-2403	158	15	the	the	DET
admet-2403	158	16	oil	oil	NOUN
admet-2403	158	17	and	and	CCONJ
admet-2403	158	18	aqueous	aqueous	ADJ
admet-2403	158	19	phases	phase	NOUN
admet-2403	158	20	of	of	ADP
admet-2403	158	21	the	the	DET
admet-2403	158	22	diluted	diluted	ADJ
admet-2403	158	23	emulsion	emulsion	NOUN
admet-2403	158	24	,	,	PUNCT
admet-2403	158	25	raising	raise	VERB
admet-2403	158	26	the	the	DET
admet-2403	158	27	emulsion	emulsion	NOUN
admet-2403	158	28	-	-	PUNCT
admet-2403	158	29	free	free	ADJ
admet-2403	158	30	drug	drug	NOUN
admet-2403	158	31	concentration	concentration	NOUN
admet-2403	158	32	from	from	ADP
admet-2403	158	33	55	55	NUM
admet-2403	158	34	to	to	ADP
admet-2403	158	35	390	390	NUM
admet-2403	158	36	µg	µg	ADV
admet-2403	158	37	ml-1	ml-1	X
admet-2403	158	38	.	.	PUNCT
admet-2403	159	1	such	such	DET
admet-2403	159	2	a	a	DET
admet-2403	159	3	7	7	NUM
admet-2403	159	4	-	-	ADJ
admet-2403	159	5	fold	fold	ADJ
admet-2403	159	6	higher	high	ADJ
admet-2403	159	7	concentration	concentration	NOUN
admet-2403	159	8	in	in	ADP
admet-2403	159	9	the	the	DET
admet-2403	159	10	immediate	immediate	ADJ
admet-2403	159	11	vicinity	vicinity	NOUN
admet-2403	159	12	of	of	ADP
admet-2403	159	13	the	the	DET
admet-2403	159	14	biomembrane	biomembrane	NOUN
admet-2403	159	15	can	can	AUX
admet-2403	159	16	justify	justify	VERB
admet-2403	159	17	the	the	DET
admet-2403	159	18	observed	observed	ADJ
admet-2403	159	19	permeation	permeation	NOUN
admet-2403	159	20	.	.	PUNCT
admet-2403	160	1	it	it	PRON
admet-2403	160	2	enhanced	enhance	VERB
admet-2403	160	3	the	the	DET
admet-2403	160	4	availability	availability	NOUN
admet-2403	160	5	of	of	ADP
admet-2403	160	6	drug	drug	NOUN
admet-2403	160	7	molecules	molecule	NOUN
admet-2403	160	8	for	for	ADP
admet-2403	160	9	permeation	permeation	NOUN
admet-2403	160	10	in	in	ADP
admet-2403	160	11	the	the	DET
admet-2403	160	12	uwl	uwl	NOUN
admet-2403	160	13	.	.	PUNCT
admet-2403	161	1	the	the	DET
admet-2403	161	2	drug	drug	NOUN
admet-2403	161	3	molecules	molecule	NOUN
admet-2403	161	4	bound	bind	VERB
admet-2403	161	5	within	within	ADP
admet-2403	161	6	the	the	DET
admet-2403	161	7	complex	complex	NOUN
admet-2403	161	8	are	be	AUX
admet-2403	161	9	in	in	ADP
admet-2403	161	10	dynamic	dynamic	ADJ
admet-2403	161	11	equilibrium	equilibrium	NOUN
admet-2403	161	12	with	with	ADP
admet-2403	161	13	the	the	DET
admet-2403	161	14	unbound	unbound	NOUN
admet-2403	161	15	ones	one	NOUN
admet-2403	161	16	.	.	PUNCT
admet-2403	162	1	while	while	SCONJ
admet-2403	162	2	neither	neither	CCONJ
admet-2403	162	3	the	the	DET
admet-2403	162	4	bound	bind	VERB
admet-2403	162	5	molecules	molecule	NOUN
admet-2403	162	6	nor	nor	CCONJ
admet-2403	162	7	the	the	DET
admet-2403	162	8	complex	complex	NOUN
admet-2403	162	9	itself	itself	PRON
admet-2403	162	10	permeate	permeate	VERB
admet-2403	162	11	the	the	DET
admet-2403	162	12	membrane	membrane	NOUN
admet-2403	162	13	,	,	PUNCT
admet-2403	162	14	unbound	unbound	NOUN
admet-2403	162	15	molecules	molecule	NOUN
admet-2403	162	16	do	do	VERB
admet-2403	162	17	so	so	ADV
admet-2403	162	18	.	.	PUNCT
admet-2403	163	1	as	as	ADP
admet-2403	163	2	a	a	DET
admet-2403	163	3	consequence	consequence	NOUN
admet-2403	163	4	of	of	ADP
admet-2403	163	5	this	this	DET
admet-2403	163	6	flux	flux	NOUN
admet-2403	163	7	,	,	PUNCT
admet-2403	163	8	other	other	ADJ
admet-2403	163	9	bound	bind	VERB
admet-2403	163	10	molecules	molecule	NOUN
admet-2403	163	11	are	be	AUX
admet-2403	163	12	released	release	VERB
admet-2403	163	13	from	from	ADP
admet-2403	163	14	the	the	DET
admet-2403	163	15	complex	complex	NOUN
admet-2403	163	16	owing	owe	VERB
admet-2403	163	17	to	to	ADP
admet-2403	163	18	the	the	DET
admet-2403	163	19	said	say	VERB
admet-2403	163	20	equilibrium	equilibrium	NOUN
admet-2403	163	21	,	,	PUNCT
admet-2403	163	22	thereby	thereby	ADV
admet-2403	163	23	further	far	ADV
admet-2403	163	24	sustaining	sustain	VERB
admet-2403	163	25	the	the	DET
admet-2403	163	26	permeation	permeation	NOUN
admet-2403	163	27	process	process	NOUN
admet-2403	163	28	[	[	X
admet-2403	163	29	36	36	NUM
admet-2403	163	30	]	]	PUNCT
admet-2403	163	31	.	.	PUNCT
admet-2403	164	1	on	on	ADP
admet-2403	164	2	the	the	DET
admet-2403	164	3	other	other	ADJ
admet-2403	164	4	hand	hand	NOUN
admet-2403	164	5	,	,	PUNCT
admet-2403	164	6	a	a	DET
admet-2403	164	7	permeation	permeation	NOUN
admet-2403	164	8	enhancement	enhancement	NOUN
admet-2403	164	9	effect	effect	NOUN
admet-2403	164	10	mediated	mediate	VERB
admet-2403	164	11	by	by	ADP
admet-2403	164	12	me	i	PRON
admet-2403	164	13	-	-	PUNCT
admet-2403	164	14	β	β	NOUN
admet-2403	164	15	-	-	NOUN
admet-2403	164	16	cd	cd	NOUN
admet-2403	164	17	is	be	AUX
admet-2403	164	18	not	not	PART
admet-2403	164	19	excluded	exclude	VERB
admet-2403	164	20	as	as	ADP
admet-2403	164	21	the	the	DET
admet-2403	164	22	amount	amount	NOUN
admet-2403	164	23	of	of	ADP
admet-2403	164	24	ppf	ppf	PROPN
admet-2403	164	25	permeated	permeate	VERB
admet-2403	164	26	was	be	AUX
admet-2403	164	27	9	9	NUM
admet-2403	164	28	-	-	NOUN
admet-2403	164	29	fold	fold	VERB
admet-2403	164	30	greater	great	ADJ
admet-2403	164	31	than	than	ADP
admet-2403	164	32	without	without	ADP
admet-2403	164	33	cyclodextrin	cyclodextrin	NOUN
admet-2403	164	34	.	.	PUNCT
admet-2403	165	1	me	i	PRON
admet-2403	165	2	-	-	PUNCT
admet-2403	165	3	β	β	NOUN
admet-2403	165	4	-	-	NOUN
admet-2403	165	5	cd	cd	NOUN
admet-2403	165	6	also	also	ADV
admet-2403	165	7	led	lead	VERB
admet-2403	165	8	to	to	ADP
admet-2403	165	9	more	more	ADJ
admet-2403	165	10	pff	pff	NOUN
admet-2403	165	11	accumulated	accumulate	VERB
admet-2403	165	12	within	within	ADP
admet-2403	165	13	the	the	DET
admet-2403	165	14	membrane	membrane	NOUN
admet-2403	165	15	(	(	PUNCT
admet-2403	165	16	1.2	1.2	NUM
admet-2403	165	17	%	%	NOUN
admet-2403	165	18	)	)	PUNCT
admet-2403	165	19	.	.	PUNCT
admet-2403	166	1	it	it	PRON
admet-2403	166	2	is	be	AUX
admet-2403	166	3	reported	report	VERB
admet-2403	166	4	that	that	SCONJ
admet-2403	166	5	cyclodextrins	cyclodextrin	NOUN
admet-2403	166	6	can	can	AUX
admet-2403	166	7	form	form	VERB
admet-2403	166	8	complexes	complex	NOUN
admet-2403	166	9	with	with	ADP
admet-2403	166	10	lipid	lipid	NOUN
admet-2403	166	11	admet	admet	PROPN
admet-2403	166	12	&	&	CCONJ
admet-2403	166	13	dmpk	dmpk	PROPN
admet-2403	166	14	12(5	12(5	NUM
admet-2403	166	15	)	)	PUNCT
admet-2403	166	16	(	(	PUNCT
admet-2403	166	17	2024	2024	NUM
admet-2403	166	18	)	)	PUNCT
admet-2403	166	19	759	759	NUM
admet-2403	166	20	-	-	SYM
admet-2403	166	21	768	768	NUM
admet-2403	166	22	a	a	DET
admet-2403	166	23	proof	proof	NOUN
admet-2403	166	24	-	-	PUNCT
admet-2403	166	25	of	of	ADP
admet-2403	166	26	-	-	PUNCT
admet-2403	166	27	concept	concept	NOUN
admet-2403	166	28	study	study	NOUN
admet-2403	166	29	for	for	ADP
admet-2403	166	30	outpatient	outpatient	NOUN
admet-2403	166	31	light	light	ADJ
admet-2403	166	32	sedation	sedation	NOUN
admet-2403	166	33	via	via	ADP
admet-2403	166	34	nasal	nasal	PROPN
admet-2403	166	35	route	route	PROPN
admet-2403	166	36	doi	doi	PROPN
admet-2403	166	37	:	:	PUNCT
admet-2403	166	38	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	166	39	765	765	NUM
admet-2403	166	40	components	component	NOUN
admet-2403	166	41	of	of	ADP
admet-2403	166	42	the	the	DET
admet-2403	166	43	cell	cell	NOUN
admet-2403	166	44	membranes	membrane	NOUN
admet-2403	166	45	[	[	X
admet-2403	166	46	37	37	NUM
admet-2403	166	47	]	]	PUNCT
admet-2403	166	48	.	.	PUNCT
admet-2403	167	1	this	this	PRON
admet-2403	167	2	alters	alter	VERB
admet-2403	167	3	the	the	DET
admet-2403	167	4	integrity	integrity	NOUN
admet-2403	167	5	of	of	ADP
admet-2403	167	6	the	the	DET
admet-2403	167	7	nasal	nasal	ADJ
admet-2403	167	8	barrier	barrier	NOUN
admet-2403	167	9	and	and	CCONJ
admet-2403	167	10	may	may	AUX
admet-2403	167	11	influence	influence	VERB
admet-2403	167	12	the	the	DET
admet-2403	167	13	elasticity	elasticity	NOUN
admet-2403	167	14	of	of	ADP
admet-2403	167	15	the	the	DET
admet-2403	167	16	nasal	nasal	PROPN
admet-2403	167	17	mucosa	mucosa	NOUN
admet-2403	167	18	,	,	PUNCT
admet-2403	167	19	ultimately	ultimately	ADV
admet-2403	167	20	leading	lead	VERB
admet-2403	167	21	to	to	ADP
admet-2403	167	22	increased	increase	VERB
admet-2403	167	23	tissue	tissue	NOUN
admet-2403	167	24	permeability	permeability	NOUN
admet-2403	167	25	.	.	PUNCT
admet-2403	168	1	conclusions	conclusion	NOUN
admet-2403	168	2	a	a	DET
admet-2403	168	3	positive	positive	ADJ
admet-2403	168	4	effect	effect	NOUN
admet-2403	168	5	of	of	ADP
admet-2403	168	6	me	i	PRON
admet-2403	168	7	-	-	PUNCT
admet-2403	168	8	β	β	NOUN
admet-2403	168	9	-	-	NOUN
admet-2403	168	10	cd	cd	PROPN
admet-2403	168	11	was	be	AUX
admet-2403	168	12	seen	see	VERB
admet-2403	168	13	on	on	ADP
admet-2403	168	14	ppf	ppf	PROPN
admet-2403	168	15	diffusion	diffusion	NOUN
admet-2403	168	16	across	across	ADP
admet-2403	168	17	the	the	DET
admet-2403	168	18	rabbit	rabbit	NOUN
admet-2403	168	19	nasal	nasal	PROPN
admet-2403	168	20	tissue	tissue	NOUN
admet-2403	168	21	,	,	PUNCT
admet-2403	168	22	mainly	mainly	ADV
admet-2403	168	23	due	due	ADP
admet-2403	168	24	to	to	ADP
admet-2403	168	25	a	a	DET
admet-2403	168	26	solubilizing	solubilize	VERB
admet-2403	168	27	action	action	NOUN
admet-2403	168	28	.	.	PUNCT
admet-2403	169	1	still	still	ADV
admet-2403	169	2	,	,	PUNCT
admet-2403	169	3	the	the	DET
admet-2403	169	4	permeation	permeation	NOUN
admet-2403	169	5	of	of	ADP
admet-2403	169	6	the	the	DET
admet-2403	169	7	drug	drug	NOUN
admet-2403	169	8	was	be	AUX
admet-2403	169	9	minimal	minimal	ADJ
admet-2403	169	10	.	.	PUNCT
admet-2403	170	1	the	the	DET
admet-2403	170	2	amount	amount	NOUN
admet-2403	170	3	transported	transport	VERB
admet-2403	170	4	does	do	AUX
admet-2403	170	5	not	not	PART
admet-2403	170	6	seem	seem	VERB
admet-2403	170	7	capable	capable	ADJ
admet-2403	170	8	of	of	ADP
admet-2403	170	9	inducing	induce	VERB
admet-2403	170	10	sedation	sedation	NOUN
admet-2403	170	11	because	because	SCONJ
admet-2403	170	12	it	it	PRON
admet-2403	170	13	was	be	AUX
admet-2403	170	14	measured	measure	VERB
admet-2403	170	15	during	during	ADP
admet-2403	170	16	3	3	NUM
admet-2403	170	17	hours	hour	NOUN
admet-2403	170	18	,	,	PUNCT
admet-2403	170	19	much	much	ADV
admet-2403	170	20	longer	long	ADJ
admet-2403	170	21	than	than	ADP
admet-2403	170	22	the	the	DET
admet-2403	170	23	average	average	ADJ
admet-2403	170	24	residence	residence	NOUN
admet-2403	170	25	time	time	NOUN
admet-2403	170	26	of	of	ADP
admet-2403	170	27	a	a	DET
admet-2403	170	28	liquid	liquid	NOUN
admet-2403	170	29	inside	inside	ADP
admet-2403	170	30	the	the	DET
admet-2403	170	31	nose	nose	NOUN
admet-2403	170	32	.	.	PUNCT
admet-2403	171	1	ppf	ppf	PROPN
admet-2403	171	2	appears	appear	VERB
admet-2403	171	3	to	to	PART
admet-2403	171	4	be	be	AUX
admet-2403	171	5	a	a	DET
admet-2403	171	6	difficult	difficult	ADJ
admet-2403	171	7	candidate	candidate	NOUN
admet-2403	171	8	for	for	ADP
admet-2403	171	9	nasal	nasal	PROPN
admet-2403	171	10	administration	administration	NOUN
admet-2403	171	11	,	,	PUNCT
admet-2403	171	12	and	and	CCONJ
admet-2403	171	13	a	a	DET
admet-2403	171	14	formulation	formulation	NOUN
admet-2403	171	15	study	study	NOUN
admet-2403	171	16	is	be	AUX
admet-2403	171	17	recommended	recommend	VERB
admet-2403	171	18	to	to	PART
admet-2403	171	19	improve	improve	VERB
admet-2403	171	20	its	its	PRON
admet-2403	171	21	water	water	NOUN
admet-2403	171	22	solubility	solubility	NOUN
admet-2403	171	23	and	and	CCONJ
admet-2403	171	24	transmucosal	transmucosal	PROPN
admet-2403	171	25	transport	transport	NOUN
admet-2403	171	26	to	to	PART
admet-2403	171	27	reach	reach	VERB
admet-2403	171	28	blood	blood	NOUN
admet-2403	171	29	levels	level	NOUN
admet-2403	171	30	that	that	PRON
admet-2403	171	31	are	be	AUX
admet-2403	171	32	useful	useful	ADJ
admet-2403	171	33	for	for	ADP
admet-2403	171	34	sedation	sedation	NOUN
admet-2403	171	35	.	.	PUNCT
admet-2403	172	1	liquid	liquid	ADJ
admet-2403	172	2	lipid	lipid	NOUN
admet-2403	172	3	-	-	PUNCT
admet-2403	172	4	based	base	VERB
admet-2403	172	5	formulations	formulation	NOUN
admet-2403	172	6	easily	easily	ADV
admet-2403	172	7	accommodate	accommodate	VERB
admet-2403	172	8	oily	oily	ADJ
admet-2403	172	9	ppf	ppf	NOUN
admet-2403	172	10	,	,	PUNCT
admet-2403	172	11	but	but	CCONJ
admet-2403	172	12	do	do	AUX
admet-2403	172	13	not	not	PART
admet-2403	172	14	release	release	VERB
admet-2403	172	15	it	it	PRON
admet-2403	172	16	enough	enough	ADV
admet-2403	172	17	in	in	ADP
admet-2403	172	18	the	the	DET
admet-2403	172	19	intranasal	intranasal	ADJ
admet-2403	172	20	aqueous	aqueous	ADJ
admet-2403	172	21	environment	environment	NOUN
admet-2403	172	22	.	.	PUNCT
admet-2403	173	1	one	one	NUM
admet-2403	173	2	exciting	exciting	ADJ
admet-2403	173	3	opportunity	opportunity	NOUN
admet-2403	173	4	may	may	AUX
admet-2403	173	5	be	be	AUX
admet-2403	173	6	represented	represent	VERB
admet-2403	173	7	by	by	ADP
admet-2403	173	8	nasal	nasal	ADJ
admet-2403	173	9	powders	powder	NOUN
admet-2403	173	10	by	by	ADP
admet-2403	173	11	exploiting	exploit	VERB
admet-2403	173	12	the	the	DET
admet-2403	173	13	amorphous	amorphous	ADJ
admet-2403	173	14	solid	solid	ADJ
admet-2403	173	15	dispersion	dispersion	NOUN
admet-2403	173	16	technology	technology	NOUN
admet-2403	174	1	[	[	X
admet-2403	174	2	38	38	NUM
admet-2403	174	3	]	]	PUNCT
admet-2403	174	4	,	,	PUNCT
admet-2403	174	5	similar	similar	ADJ
admet-2403	174	6	to	to	ADP
admet-2403	174	7	what	what	PRON
admet-2403	174	8	has	have	AUX
admet-2403	174	9	been	be	AUX
admet-2403	174	10	done	do	VERB
admet-2403	174	11	for	for	ADP
admet-2403	174	12	other	other	ADJ
admet-2403	174	13	drugs	drug	NOUN
admet-2403	174	14	candidates	candidate	NOUN
admet-2403	174	15	for	for	ADP
admet-2403	174	16	nasal	nasal	PROPN
admet-2403	174	17	administration	administration	NOUN
admet-2403	174	18	,	,	PUNCT
admet-2403	174	19	e.g.	e.g.	ADV
admet-2403	174	20	,	,	PUNCT
admet-2403	174	21	budesonide	budesonide	NOUN
admet-2403	174	22	,	,	PUNCT
admet-2403	174	23	which	which	PRON
admet-2403	174	24	is	be	AUX
admet-2403	174	25	even	even	ADV
admet-2403	174	26	less	less	ADV
admet-2403	174	27	soluble	soluble	ADJ
admet-2403	174	28	in	in	ADP
admet-2403	174	29	water	water	NOUN
admet-2403	174	30	than	than	ADP
admet-2403	174	31	ppf	ppf	PROPN
admet-2403	174	32	[	[	X
admet-2403	174	33	39	39	NUM
admet-2403	174	34	]	]	PUNCT
admet-2403	174	35	.	.	PUNCT
admet-2403	175	1	conflict	conflict	NOUN
admet-2403	175	2	of	of	ADP
admet-2403	175	3	interest	interest	NOUN
admet-2403	175	4	:	:	PUNCT
admet-2403	175	5	the	the	DET
admet-2403	175	6	authors	author	NOUN
admet-2403	175	7	declare	declare	VERB
admet-2403	175	8	that	that	SCONJ
admet-2403	175	9	they	they	PRON
admet-2403	175	10	have	have	VERB
admet-2403	175	11	no	no	DET
admet-2403	175	12	known	know	VERB
admet-2403	175	13	competing	compete	VERB
admet-2403	175	14	financial	financial	ADJ
admet-2403	175	15	interests	interest	NOUN
admet-2403	175	16	nor	nor	CCONJ
admet-2403	175	17	personal	personal	ADJ
admet-2403	175	18	relationships	relationship	NOUN
admet-2403	175	19	that	that	PRON
admet-2403	175	20	could	could	AUX
admet-2403	175	21	have	have	AUX
admet-2403	175	22	appeared	appear	VERB
admet-2403	175	23	to	to	PART
admet-2403	175	24	influence	influence	VERB
admet-2403	175	25	the	the	DET
admet-2403	175	26	work	work	NOUN
admet-2403	175	27	reported	report	VERB
admet-2403	175	28	in	in	ADP
admet-2403	175	29	this	this	DET
admet-2403	175	30	paper	paper	NOUN
admet-2403	175	31	.	.	PUNCT
admet-2403	176	1	author	author	NOUN
admet-2403	176	2	’s	’s	PART
admet-2403	176	3	contribution	contribution	NOUN
admet-2403	176	4	:	:	PUNCT
admet-2403	176	5	all	all	DET
admet-2403	176	6	authors	author	NOUN
admet-2403	176	7	contributed	contribute	VERB
admet-2403	176	8	to	to	ADP
admet-2403	176	9	the	the	DET
admet-2403	176	10	study	study	NOUN
admet-2403	176	11	conception	conception	NOUN
admet-2403	176	12	and	and	CCONJ
admet-2403	176	13	design	design	NOUN
admet-2403	176	14	.	.	PUNCT
admet-2403	177	1	material	material	NOUN
admet-2403	177	2	preparation	preparation	NOUN
admet-2403	177	3	,	,	PUNCT
admet-2403	177	4	data	datum	NOUN
admet-2403	177	5	collection	collection	NOUN
admet-2403	177	6	and	and	CCONJ
admet-2403	177	7	analysis	analysis	NOUN
admet-2403	177	8	were	be	AUX
admet-2403	177	9	performed	perform	VERB
admet-2403	177	10	by	by	ADP
admet-2403	177	11	md	md	PROPN
admet-2403	177	12	.	.	PROPN
admet-2403	177	13	spampinato	spampinato	PROPN
admet-2403	177	14	,	,	PUNCT
admet-2403	177	15	a.	a.	PROPN
admet-2403	177	16	costanzini	costanzini	PROPN
admet-2403	177	17	,	,	PUNCT
admet-2403	177	18	f.	f.	PROPN
admet-2403	177	19	bortolotti	bortolotti	PROPN
admet-2403	177	20	and	and	CCONJ
admet-2403	177	21	s.	s.	PROPN
admet-2403	177	22	banella	banella	PROPN
admet-2403	177	23	.	.	PUNCT
admet-2403	178	1	r.	r.	PROPN
admet-2403	178	2	de	de	PROPN
admet-2403	178	3	giorgio	giorgio	PROPN
admet-2403	178	4	,	,	PUNCT
admet-2403	178	5	a.	a.	NOUN
admet-2403	178	6	passaro	passaro	NOUN
admet-2403	178	7	,	,	PUNCT
admet-2403	178	8	n.	n.	NOUN
admet-2403	178	9	realdon	realdon	NOUN
admet-2403	178	10	and	and	CCONJ
admet-2403	178	11	g.	g.	PROPN
admet-2403	178	12	colombo	colombo	PROPN
admet-2403	178	13	provided	provide	VERB
admet-2403	178	14	financial	financial	ADJ
admet-2403	178	15	support	support	NOUN
admet-2403	178	16	and	and	CCONJ
admet-2403	178	17	supervised	supervise	VERB
admet-2403	178	18	all	all	DET
admet-2403	178	19	phases	phase	NOUN
admet-2403	178	20	of	of	ADP
admet-2403	178	21	the	the	DET
admet-2403	178	22	study	study	NOUN
admet-2403	178	23	,	,	PUNCT
admet-2403	178	24	including	include	VERB
admet-2403	178	25	the	the	DET
admet-2403	178	26	manuscript	manuscript	NOUN
admet-2403	178	27	writing	writing	NOUN
admet-2403	178	28	.	.	PUNCT
admet-2403	179	1	all	all	DET
admet-2403	179	2	authors	author	NOUN
admet-2403	179	3	read	read	VERB
admet-2403	179	4	and	and	CCONJ
admet-2403	179	5	approved	approve	VERB
admet-2403	179	6	the	the	DET
admet-2403	179	7	final	final	ADJ
admet-2403	179	8	manuscript	manuscript	NOUN
admet-2403	179	9	.	.	PUNCT
admet-2403	180	1	data	datum	NOUN
admet-2403	180	2	availability	availability	NOUN
admet-2403	180	3	:	:	PUNCT
admet-2403	180	4	the	the	DET
admet-2403	180	5	datasets	dataset	NOUN
admet-2403	180	6	generated	generate	VERB
admet-2403	180	7	during	during	ADP
admet-2403	180	8	and/or	and/or	CCONJ
admet-2403	180	9	analyzed	analyze	VERB
admet-2403	180	10	during	during	ADP
admet-2403	180	11	the	the	DET
admet-2403	180	12	current	current	ADJ
admet-2403	180	13	study	study	NOUN
admet-2403	180	14	are	be	AUX
admet-2403	180	15	not	not	PART
admet-2403	180	16	publicly	publicly	ADV
admet-2403	180	17	available	available	ADJ
admet-2403	180	18	,	,	PUNCT
admet-2403	180	19	but	but	CCONJ
admet-2403	180	20	are	be	AUX
admet-2403	180	21	available	available	ADJ
admet-2403	180	22	from	from	ADP
admet-2403	180	23	the	the	DET
admet-2403	180	24	corresponding	corresponding	ADJ
admet-2403	180	25	author	author	NOUN
admet-2403	180	26	on	on	ADP
admet-2403	180	27	reasonable	reasonable	ADJ
admet-2403	180	28	request	request	NOUN
admet-2403	180	29	.	.	PUNCT
admet-2403	181	1	funding	funding	NOUN
admet-2403	181	2	:	:	PUNCT
admet-2403	181	3	this	this	DET
admet-2403	181	4	research	research	NOUN
admet-2403	181	5	received	receive	VERB
admet-2403	181	6	no	no	DET
admet-2403	181	7	specific	specific	ADJ
admet-2403	181	8	grant	grant	NOUN
admet-2403	181	9	from	from	ADP
admet-2403	181	10	any	any	DET
admet-2403	181	11	funding	funding	NOUN
admet-2403	181	12	agency	agency	NOUN
admet-2403	181	13	in	in	ADP
admet-2403	181	14	the	the	DET
admet-2403	181	15	public	public	ADJ
admet-2403	181	16	,	,	PUNCT
admet-2403	181	17	commercial	commercial	ADJ
admet-2403	181	18	,	,	PUNCT
admet-2403	181	19	or	or	CCONJ
admet-2403	181	20	notfor	notfor	NOUN
admet-2403	181	21	-	-	PUNCT
admet-2403	181	22	profit	profit	NOUN
admet-2403	181	23	sectors	sector	NOUN
admet-2403	181	24	.	.	PUNCT
admet-2403	182	1	ethics	ethic	NOUN
admet-2403	182	2	approval	approval	NOUN
admet-2403	182	3	:	:	PUNCT
admet-2403	182	4	ethical	ethical	ADJ
admet-2403	182	5	approval	approval	NOUN
admet-2403	182	6	is	be	AUX
admet-2403	182	7	not	not	PART
admet-2403	182	8	applicable	applicable	ADJ
admet-2403	182	9	for	for	ADP
admet-2403	182	10	this	this	DET
admet-2403	182	11	article	article	NOUN
admet-2403	182	12	because	because	SCONJ
admet-2403	182	13	no	no	DET
admet-2403	182	14	live	live	ADJ
admet-2403	182	15	animals	animal	NOUN
admet-2403	182	16	were	be	AUX
admet-2403	182	17	used	use	VERB
admet-2403	182	18	for	for	ADP
admet-2403	182	19	the	the	DET
admet-2403	182	20	experiments	experiment	NOUN
admet-2403	182	21	.	.	PUNCT
admet-2403	183	1	references	reference	NOUN
admet-2403	183	2	[	[	X
admet-2403	183	3	1	1	NUM
admet-2403	183	4	]	]	X
admet-2403	183	5	a.y	a.y	PROPN
admet-2403	183	6	.	.	PUNCT
admet-2403	184	1	feng	feng	PROPN
admet-2403	184	2	,	,	PUNCT
admet-2403	184	3	a.d	a.d	PROPN
admet-2403	184	4	.	.	PROPN
admet-2403	184	5	kaye	kaye	PROPN
admet-2403	184	6	,	,	PUNCT
admet-2403	184	7	r.j	r.j	PROPN
admet-2403	184	8	.	.	PROPN
admet-2403	184	9	kaye	kaye	PROPN
admet-2403	184	10	,	,	PUNCT
admet-2403	184	11	k.	k.	PROPN
admet-2403	184	12	belani	belani	PROPN
admet-2403	184	13	,	,	PUNCT
admet-2403	184	14	r.d	r.d	PROPN
admet-2403	184	15	.	.	PROPN
admet-2403	184	16	urman	urman	ADJ
admet-2403	184	17	.	.	PUNCT
admet-2403	185	1	novel	novel	ADJ
admet-2403	185	2	propofol	propofol	NOUN
admet-2403	185	3	derivatives	derivative	NOUN
admet-2403	185	4	and	and	CCONJ
admet-2403	185	5	implications	implication	NOUN
admet-2403	185	6	for	for	ADP
admet-2403	185	7	anesthesia	anesthesia	NOUN
admet-2403	185	8	practice	practice	NOUN
admet-2403	185	9	.	.	PUNCT
admet-2403	186	1	journal	journal	PROPN
admet-2403	186	2	of	of	ADP
admet-2403	186	3	anaesthesiology	anaesthesiology	NOUN
admet-2403	186	4	clinical	clinical	ADJ
admet-2403	186	5	pharmacology	pharmacology	NOUN
admet-2403	186	6	33	33	NUM
admet-2403	186	7	(	(	PUNCT
admet-2403	186	8	2017	2017	NUM
admet-2403	186	9	)	)	PUNCT
admet-2403	186	10	9	9	NUM
admet-2403	186	11	-	-	SYM
admet-2403	186	12	15	15	NUM
admet-2403	186	13	.	.	PUNCT
admet-2403	187	1	http://dx.doi.org/10.4103/0970-9185.202205	http://dx.doi.org/10.4103/0970-9185.202205	PRON
admet-2403	188	1	[	[	X
admet-2403	188	2	2	2	NUM
admet-2403	188	3	]	]	PUNCT
admet-2403	188	4	b.	b.	PROPN
admet-2403	188	5	wilhelms	wilhelms	PROPN
admet-2403	188	6	,	,	PUNCT
admet-2403	188	7	j.	j.	PROPN
admet-2403	188	8	broscheit	broscheit	PROPN
admet-2403	188	9	,	,	PUNCT
admet-2403	188	10	s.	s.	PROPN
admet-2403	188	11	shityakov	shityakov	PROPN
admet-2403	188	12	.	.	PUNCT
admet-2403	189	1	chemical	chemical	ADJ
admet-2403	189	2	analysis	analysis	NOUN
admet-2403	189	3	and	and	CCONJ
admet-2403	189	4	molecular	molecular	ADJ
admet-2403	189	5	modelling	modelling	NOUN
admet-2403	189	6	of	of	ADP
admet-2403	189	7	cyclodextrinformulated	cyclodextrinformulate	VERB
admet-2403	189	8	propofol	propofol	NOUN
admet-2403	189	9	and	and	CCONJ
admet-2403	189	10	its	its	PRON
admet-2403	189	11	sodium	sodium	NOUN
admet-2403	189	12	salt	salt	NOUN
admet-2403	189	13	to	to	PART
admet-2403	189	14	improve	improve	VERB
admet-2403	189	15	drug	drug	NOUN
admet-2403	189	16	solubility	solubility	NOUN
admet-2403	189	17	,	,	PUNCT
admet-2403	189	18	stability	stability	NOUN
admet-2403	189	19	and	and	CCONJ
admet-2403	189	20	pharmacokinetics	pharmacokinetic	NOUN
admet-2403	189	21	(	(	PUNCT
admet-2403	189	22	cytogenotoxicity	cytogenotoxicity	NOUN
admet-2403	189	23	)	)	PUNCT
admet-2403	189	24	.	.	PUNCT
admet-2403	190	1	pharmaceuticals	pharmaceutical	NOUN
admet-2403	190	2	(	(	PUNCT
admet-2403	190	3	basel	basel	PROPN
admet-2403	190	4	)	)	PUNCT
admet-2403	190	5	16	16	NUM
admet-2403	190	6	(	(	PUNCT
admet-2403	190	7	2023	2023	NUM
admet-2403	190	8	)	)	PUNCT
admet-2403	190	9	667	667	NUM
admet-2403	190	10	.	.	PUNCT
admet-2403	191	1	https://doi.org/10.3390/ph16050667	https://doi.org/10.3390/ph16050667	NOUN
admet-2403	192	1	[	[	X
admet-2403	192	2	3	3	NUM
admet-2403	192	3	]	]	X
admet-2403	192	4	i.	i.	PROPN
admet-2403	192	5	cappellini	cappellini	PROPN
admet-2403	192	6	,	,	PUNCT
admet-2403	192	7	g.	g.	PROPN
admet-2403	192	8	bavestrello	bavestrello	PROPN
admet-2403	192	9	piccini	piccini	PROPN
admet-2403	192	10	,	,	PUNCT
admet-2403	192	11	l.	l.	PROPN
admet-2403	192	12	campagnola	campagnola	PROPN
admet-2403	192	13	,	,	PUNCT
admet-2403	192	14	c.	c.	PROPN
admet-2403	192	15	bochicchio	bochicchio	PROPN
admet-2403	192	16	,	,	PUNCT
admet-2403	192	17	r.	r.	PROPN
admet-2403	192	18	carente	carente	PROPN
admet-2403	192	19	,	,	PUNCT
admet-2403	192	20	f.	f.	PROPN
admet-2403	192	21	lai	lai	PROPN
admet-2403	192	22	,	,	PUNCT
admet-2403	192	23	s.	s.	PROPN
admet-2403	192	24	magazzini	magazzini	PROPN
admet-2403	192	25	,	,	PUNCT
admet-2403	192	26	g.	g.	PROPN
admet-2403	192	27	consales	consales	PROPN
admet-2403	192	28	.	.	PUNCT
admet-2403	193	1	procedural	procedural	ADJ
admet-2403	193	2	sedation	sedation	NOUN
admet-2403	193	3	in	in	ADP
admet-2403	193	4	emergency	emergency	NOUN
admet-2403	193	5	department	department	NOUN
admet-2403	193	6	:	:	PUNCT
admet-2403	193	7	a	a	DET
admet-2403	193	8	narrative	narrative	NOUN
admet-2403	193	9	review	review	NOUN
admet-2403	193	10	.	.	PUNCT
admet-2403	194	1	emergency	emergency	NOUN
admet-2403	194	2	care	care	NOUN
admet-2403	194	3	and	and	CCONJ
admet-2403	194	4	medicine	medicine	NOUN
admet-2403	194	5	1	1	NUM
admet-2403	194	6	(	(	PUNCT
admet-2403	194	7	2024	2024	NUM
admet-2403	194	8	)	)	PUNCT
admet-2403	194	9	103	103	NUM
admet-2403	194	10	-	-	SYM
admet-2403	194	11	136	136	NUM
admet-2403	194	12	.	.	PUNCT
admet-2403	195	1	https://doi.org/10.3390/ecm1020014	https://doi.org/10.3390/ecm1020014	NOUN
admet-2403	196	1	[	[	X
admet-2403	196	2	4	4	NUM
admet-2403	196	3	]	]	X
admet-2403	196	4	w.h	w.h	PROPN
admet-2403	196	5	.	.	PROPN
admet-2403	196	6	cordell	cordell	PROPN
admet-2403	196	7	,	,	PUNCT
admet-2403	196	8	k.k	k.k	PROPN
admet-2403	196	9	.	.	PROPN
admet-2403	196	10	keene	keene	PROPN
admet-2403	196	11	,	,	PUNCT
admet-2403	196	12	b.k	b.k	PROPN
admet-2403	196	13	.	.	PROPN
admet-2403	196	14	giles	giles	PROPN
admet-2403	196	15	,	,	PUNCT
admet-2403	196	16	j.b	j.b	PROPN
admet-2403	196	17	.	.	PROPN
admet-2403	196	18	jones	jones	PROPN
admet-2403	196	19	,	,	PUNCT
admet-2403	196	20	j.h	j.h	PROPN
admet-2403	196	21	.	.	PROPN
admet-2403	196	22	jones	jones	PROPN
admet-2403	196	23	,	,	PUNCT
admet-2403	196	24	e.j	e.j	PROPN
admet-2403	196	25	.	.	PROPN
admet-2403	196	26	brizendine	brizendine	PROPN
admet-2403	196	27	.	.	PUNCT
admet-2403	197	1	the	the	DET
admet-2403	197	2	high	high	ADJ
admet-2403	197	3	prevalence	prevalence	NOUN
admet-2403	197	4	of	of	ADP
admet-2403	197	5	pain	pain	NOUN
admet-2403	197	6	in	in	ADP
admet-2403	197	7	emergency	emergency	NOUN
admet-2403	197	8	medical	medical	ADJ
admet-2403	197	9	care	care	NOUN
admet-2403	197	10	.	.	PUNCT
admet-2403	198	1	the	the	DET
admet-2403	198	2	american	american	PROPN
admet-2403	198	3	journal	journal	PROPN
admet-2403	198	4	of	of	ADP
admet-2403	198	5	emergency	emergency	NOUN
admet-2403	198	6	medicine	medicine	NOUN
admet-2403	198	7	20	20	NUM
admet-2403	198	8	(	(	PUNCT
admet-2403	198	9	2002	2002	NUM
admet-2403	198	10	)	)	PUNCT
admet-2403	198	11	165	165	NUM
admet-2403	198	12	-	-	SYM
admet-2403	198	13	169	169	NUM
admet-2403	198	14	.	.	PUNCT
admet-2403	199	1	https://doi.org/10.1053/ajem.2002.32643	https://doi.org/10.1053/ajem.2002.32643	PROPN
admet-2403	199	2	[	[	X
admet-2403	199	3	5	5	NUM
admet-2403	199	4	]	]	X
admet-2403	199	5	eusem	eusem	ADJ
admet-2403	199	6	european	european	PROPN
admet-2403	199	7	curriculum	curriculum	NOUN
admet-2403	199	8	of	of	ADP
admet-2403	199	9	emergency	emergency	NOUN
admet-2403	199	10	medicine	medicine	NOUN
admet-2403	199	11	,	,	PUNCT
admet-2403	199	12	https://eusem.org/education/curriculum/european-curriculum-of-emergency-medicine	https://eusem.org/education/curriculum/european-curriculum-of-emergency-medicine	PROPN
admet-2403	199	13	(	(	PUNCT
admet-2403	199	14	last	last	ADV
admet-2403	199	15	accessed	access	VERB
admet-2403	199	16	july	july	PROPN
admet-2403	199	17	30th	30th	NUM
admet-2403	199	18	,	,	PUNCT
admet-2403	199	19	2024	2024	NUM
admet-2403	199	20	)	)	PUNCT
admet-2403	200	1	[	[	X
admet-2403	200	2	6	6	NUM
admet-2403	200	3	]	]	PUNCT
admet-2403	200	4	s.	s.	PROPN
admet-2403	200	5	serra	serra	PROPN
admet-2403	200	6	,	,	PUNCT
admet-2403	200	7	m.d	m.d	PROPN
admet-2403	200	8	.	.	PROPN
admet-2403	200	9	spampinato	spampinato	PROPN
admet-2403	200	10	,	,	PUNCT
admet-2403	200	11	a.	a.	PROPN
admet-2403	200	12	riccardi	riccardi	PROPN
admet-2403	200	13	,	,	PUNCT
admet-2403	200	14	m.	m.	NOUN
admet-2403	200	15	guarino	guarino	PROPN
admet-2403	200	16	,	,	PUNCT
admet-2403	200	17	a.	a.	NOUN
admet-2403	200	18	fabbri	fabbri	NOUN
admet-2403	200	19	,	,	PUNCT
admet-2403	200	20	l.	l.	PROPN
admet-2403	200	21	orsi	orsi	PROPN
admet-2403	200	22	,	,	PUNCT
admet-2403	200	23	f.	f.	PROPN
admet-2403	200	24	de	de	PROPN
admet-2403	200	25	iaco	iaco	PROPN
admet-2403	200	26	.	.	PUNCT
admet-2403	201	1	pain	pain	NOUN
admet-2403	201	2	management	management	NOUN
admet-2403	201	3	at	at	ADP
admet-2403	201	4	the	the	DET
admet-2403	201	5	end	end	NOUN
admet-2403	201	6	of	of	ADP
admet-2403	201	7	life	life	NOUN
admet-2403	201	8	in	in	ADP
admet-2403	201	9	the	the	DET
admet-2403	201	10	emergency	emergency	NOUN
admet-2403	201	11	department	department	NOUN
admet-2403	201	12	:	:	PUNCT
admet-2403	201	13	a	a	DET
admet-2403	201	14	narrative	narrative	NOUN
admet-2403	201	15	review	review	NOUN
admet-2403	201	16	of	of	ADP
admet-2403	201	17	the	the	DET
admet-2403	201	18	literature	literature	NOUN
admet-2403	201	19	and	and	CCONJ
admet-2403	201	20	a	a	DET
admet-2403	201	21	practical	practical	ADJ
admet-2403	201	22	clinical	clinical	ADJ
admet-2403	201	23	approach	approach	NOUN
admet-2403	201	24	.	.	PUNCT
admet-2403	202	1	journal	journal	NOUN
admet-2403	202	2	of	of	ADP
admet-2403	202	3	clinical	clinical	ADJ
admet-2403	202	4	medicine	medicine	NOUN
admet-2403	202	5	12	12	NUM
admet-2403	202	6	(	(	PUNCT
admet-2403	202	7	2023	2023	NUM
admet-2403	202	8	)	)	PUNCT
admet-2403	202	9	4357	4357	NUM
admet-2403	202	10	.	.	PUNCT
admet-2403	203	1	https://doi.org/10.3390/jcm12134357	https://doi.org/10.3390/jcm12134357	PROPN
admet-2403	203	2	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	203	3	http://dx.doi.org/10.4103/0970-9185.202205	http://dx.doi.org/10.4103/0970-9185.202205	PRON
admet-2403	203	4	https://doi.org/10.3390/ph16050667	https://doi.org/10.3390/ph16050667	ADJ
admet-2403	203	5	https://doi.org/10.3390/ecm1020014	https://doi.org/10.3390/ecm1020014	X
admet-2403	203	6	https://doi.org/10.1053/ajem.2002.32643	https://doi.org/10.1053/ajem.2002.32643	PROPN
admet-2403	203	7	https://eusem.org/education/curriculum/european-curriculum-of-emergency-medicine	https://eusem.org/education/curriculum/european-curriculum-of-emergency-medicine	PROPN
admet-2403	203	8	m.	m.	PROPN
admet-2403	203	9	d.	d.	PROPN
admet-2403	203	10	spampinato	spampinato	PROPN
admet-2403	203	11	et	et	PROPN
admet-2403	203	12	al	al	PROPN
admet-2403	203	13	.	.	PROPN
admet-2403	203	14	admet	admet	PROPN
admet-2403	203	15	&	&	CCONJ
admet-2403	203	16	dmpk	dmpk	PROPN
admet-2403	203	17	12(5	12(5	NUM
admet-2403	203	18	)	)	PUNCT
admet-2403	203	19	(	(	PUNCT
admet-2403	203	20	2024	2024	NUM
admet-2403	203	21	)	)	PUNCT
admet-2403	203	22	759	759	NUM
admet-2403	203	23	-	-	SYM
admet-2403	203	24	768	768	NUM
admet-2403	203	25	766	766	NUM
admet-2403	203	26	[	[	X
admet-2403	203	27	7	7	NUM
admet-2403	203	28	]	]	X
admet-2403	203	29	y.	y.	PROPN
admet-2403	203	30	kanno	kanno	PROPN
admet-2403	203	31	,	,	PUNCT
admet-2403	203	32	t.	t.	PROPN
admet-2403	203	33	ohira	ohira	PROPN
admet-2403	203	34	,	,	PUNCT
admet-2403	203	35	y.	y.	PROPN
admet-2403	203	36	harada	harada	PROPN
admet-2403	203	37	,	,	PUNCT
admet-2403	203	38	s.	s.	PROPN
admet-2403	203	39	koshita	koshita	PROPN
admet-2403	203	40	,	,	PUNCT
admet-2403	203	41	t.	t.	PROPN
admet-2403	203	42	ogawa	ogawa	PROPN
admet-2403	203	43	,	,	PUNCT
admet-2403	203	44	h.	h.	PROPN
admet-2403	203	45	kusunose	kusunose	PROPN
admet-2403	203	46	,	,	PUNCT
admet-2403	203	47	y.	y.	PROPN
admet-2403	203	48	koike	koike	PROPN
admet-2403	203	49	,	,	PUNCT
admet-2403	203	50	t.	t.	PROPN
admet-2403	203	51	yamagata	yamagata	PROPN
admet-2403	203	52	,	,	PUNCT
admet-2403	203	53	t.	t.	PROPN
admet-2403	203	54	sakai	sakai	PROPN
admet-2403	203	55	,	,	PUNCT
admet-2403	203	56	k.	k.	PROPN
admet-2403	203	57	masu	masu	PROPN
admet-2403	203	58	,	,	PUNCT
admet-2403	203	59	k.	k.	PROPN
admet-2403	203	60	yonamine	yonamine	PROPN
admet-2403	203	61	,	,	PUNCT
admet-2403	203	62	k.	k.	PROPN
admet-2403	203	63	miyamoto	miyamoto	PROPN
admet-2403	203	64	,	,	PUNCT
admet-2403	203	65	m.	m.	NOUN
admet-2403	203	66	tanaka	tanaka	PROPN
admet-2403	203	67	,	,	PUNCT
admet-2403	203	68	t.	t.	PROPN
admet-2403	203	69	shimada	shimada	PROPN
admet-2403	203	70	,	,	PUNCT
admet-2403	203	71	f.	f.	PROPN
admet-2403	203	72	kozakai	kozakai	PROPN
admet-2403	203	73	,	,	PUNCT
admet-2403	203	74	k.	k.	PROPN
admet-2403	203	75	endo	endo	PROPN
admet-2403	203	76	,	,	PUNCT
admet-2403	203	77	h.	h.	PROPN
admet-2403	203	78	okano	okano	PROPN
admet-2403	203	79	,	,	PUNCT
admet-2403	203	80	d.	d.	PROPN
admet-2403	203	81	komabayashi	komabayashi	PROPN
admet-2403	203	82	,	,	PUNCT
admet-2403	203	83	t.	t.	PROPN
admet-2403	203	84	shimizu	shimizu	PROPN
admet-2403	203	85	,	,	PUNCT
admet-2403	203	86	s.	s.	PROPN
admet-2403	203	87	suzuki	suzuki	PROPN
admet-2403	203	88	,	,	PUNCT
admet-2403	203	89	k.	k.	PROPN
admet-2403	203	90	ito	ito	PROPN
admet-2403	203	91	.	.	PROPN
admet-2403	204	1	safety	safety	NOUN
admet-2403	204	2	and	and	CCONJ
admet-2403	204	3	recipient	recipient	NOUN
admet-2403	204	4	satisfaction	satisfaction	NOUN
admet-2403	204	5	of	of	ADP
admet-2403	204	6	propofol	propofol	ADJ
admet-2403	204	7	sedation	sedation	NOUN
admet-2403	204	8	in	in	ADP
admet-2403	204	9	outpatient	outpatient	NOUN
admet-2403	204	10	endoscopy	endoscopy	NOUN
admet-2403	204	11	:	:	PUNCT
admet-2403	204	12	a	a	DET
admet-2403	204	13	24	24	NUM
admet-2403	204	14	-	-	PUNCT
admet-2403	204	15	hour	hour	NOUN
admet-2403	204	16	prospective	prospective	ADJ
admet-2403	204	17	investigation	investigation	NOUN
admet-2403	204	18	using	use	VERB
admet-2403	204	19	a	a	DET
admet-2403	204	20	questionnaire	questionnaire	NOUN
admet-2403	204	21	survey	survey	NOUN
admet-2403	204	22	.	.	PUNCT
admet-2403	205	1	clinical	clinical	ADJ
admet-2403	205	2	endoscopy	endoscopy	NOUN
admet-2403	205	3	54	54	NUM
admet-2403	205	4	(	(	PUNCT
admet-2403	205	5	2021	2021	NUM
admet-2403	205	6	)	)	PUNCT
admet-2403	205	7	340	340	NUM
admet-2403	205	8	-	-	SYM
admet-2403	205	9	347	347	NUM
admet-2403	205	10	.	.	PUNCT
admet-2403	206	1	https://doi.org/10.5946/ce.2020.138	https://doi.org/10.5946/ce.2020.138	VERB
admet-2403	207	1	[	[	X
admet-2403	207	2	8	8	NUM
admet-2403	207	3	]	]	X
admet-2403	207	4	g.f	g.f	PROPN
admet-2403	207	5	.	.	PROPN
admet-2403	207	6	ferrazzano	ferrazzano	PROPN
admet-2403	207	7	,	,	PUNCT
admet-2403	207	8	t.	t.	PROPN
admet-2403	207	9	cantile	cantile	ADJ
admet-2403	207	10	,	,	PUNCT
admet-2403	207	11	m.	m.	NOUN
admet-2403	207	12	quaraniello	quaraniello	PROPN
admet-2403	207	13	,	,	PUNCT
admet-2403	207	14	m.	m.	NOUN
admet-2403	207	15	iannuzzi	iannuzzi	NOUN
admet-2403	207	16	,	,	PUNCT
admet-2403	207	17	d.	d.	PROPN
admet-2403	207	18	palumbo	palumbo	PROPN
admet-2403	207	19	,	,	PUNCT
admet-2403	207	20	g.	g.	PROPN
admet-2403	207	21	servillo	servillo	PROPN
admet-2403	207	22	,	,	PUNCT
admet-2403	207	23	s.	s.	PROPN
admet-2403	207	24	caruso	caruso	PROPN
admet-2403	207	25	,	,	PUNCT
admet-2403	207	26	f.	f.	PROPN
admet-2403	207	27	fiasca	fiasca	PROPN
admet-2403	207	28	,	,	PUNCT
admet-2403	207	29	a.	a.	PROPN
admet-2403	207	30	ingenito	ingenito	PROPN
admet-2403	207	31	.	.	PUNCT
admet-2403	208	1	effectiveness	effectiveness	NOUN
admet-2403	208	2	and	and	CCONJ
admet-2403	208	3	safety	safety	NOUN
admet-2403	208	4	of	of	ADP
admet-2403	208	5	intravenous	intravenous	ADJ
admet-2403	208	6	sedation	sedation	NOUN
admet-2403	208	7	with	with	ADP
admet-2403	208	8	propofol	propofol	NOUN
admet-2403	208	9	in	in	ADP
admet-2403	208	10	non	non	ADJ
admet-2403	208	11	-	-	ADJ
admet-2403	208	12	operating	operate	VERB
admet-2403	208	13	room	room	NOUN
admet-2403	208	14	anesthesia	anesthesia	PROPN
admet-2403	208	15	(	(	PUNCT
admet-2403	208	16	nora	nora	PROPN
admet-2403	208	17	)	)	PUNCT
admet-2403	208	18	for	for	ADP
admet-2403	208	19	dental	dental	ADJ
admet-2403	208	20	treatment	treatment	NOUN
admet-2403	208	21	in	in	ADP
admet-2403	208	22	uncooperative	uncooperative	ADJ
admet-2403	208	23	paediatric	paediatric	ADJ
admet-2403	208	24	patients	patient	NOUN
admet-2403	208	25	.	.	PUNCT
admet-2403	209	1	children	child	NOUN
admet-2403	209	2	(	(	PUNCT
admet-2403	209	3	basel	basel	PROPN
admet-2403	209	4	)	)	PUNCT
admet-2403	209	5	8	8	NUM
admet-2403	209	6	(	(	PUNCT
admet-2403	209	7	2021	2021	NUM
admet-2403	209	8	)	)	PUNCT
admet-2403	209	9	648	648	NUM
admet-2403	209	10	.	.	PUNCT
admet-2403	210	1	https://doi.org/10.3390/children8080648	https://doi.org/10.3390/children8080648	VERB
admet-2403	211	1	[	[	X
admet-2403	211	2	9	9	NUM
admet-2403	211	3	]	]	PUNCT
admet-2403	211	4	m.	m.	NOUN
admet-2403	211	5	kazi	kazi	PROPN
admet-2403	211	6	,	,	PUNCT
admet-2403	211	7	a.	a.	PROPN
admet-2403	211	8	alqahtani	alqahtani	PROPN
admet-2403	211	9	,	,	PUNCT
admet-2403	211	10	m.	m.	NOUN
admet-2403	211	11	alharbi	alharbi	PROPN
admet-2403	211	12	,	,	PUNCT
admet-2403	211	13	a.	a.	PROPN
admet-2403	211	14	ahmad	ahmad	PROPN
admet-2403	211	15	,	,	PUNCT
admet-2403	211	16	m.d	m.d	PROPN
admet-2403	211	17	.	.	PROPN
admet-2403	211	18	hussain	hussain	PROPN
admet-2403	211	19	,	,	PUNCT
admet-2403	211	20	h.	h.	PROPN
admet-2403	211	21	alothaid	alothaid	PROPN
admet-2403	211	22	,	,	PUNCT
admet-2403	211	23	m.s	m.s	PROPN
admet-2403	211	24	.	.	PROPN
admet-2403	211	25	aldughaim	aldughaim	PROPN
admet-2403	211	26	.	.	PUNCT
admet-2403	212	1	the	the	DET
admet-2403	212	2	development	development	NOUN
admet-2403	212	3	and	and	CCONJ
admet-2403	212	4	optimization	optimization	NOUN
admet-2403	212	5	of	of	ADP
admet-2403	212	6	lipid	lipid	NOUN
admet-2403	212	7	-	-	PUNCT
admet-2403	212	8	based	base	VERB
admet-2403	212	9	self	self	NOUN
admet-2403	212	10	-	-	PUNCT
admet-2403	212	11	nanoemulsifying	nanoemulsifye	VERB
admet-2403	212	12	drug	drug	NOUN
admet-2403	212	13	delivery	delivery	NOUN
admet-2403	212	14	systems	system	NOUN
admet-2403	212	15	for	for	ADP
admet-2403	212	16	the	the	DET
admet-2403	212	17	intravenous	intravenous	ADJ
admet-2403	212	18	delivery	delivery	NOUN
admet-2403	212	19	of	of	ADP
admet-2403	212	20	propofol	propofol	NOUN
admet-2403	212	21	.	.	PUNCT
admet-2403	213	1	molecules	molecule	NOUN
admet-2403	213	2	28	28	NUM
admet-2403	213	3	(	(	PUNCT
admet-2403	213	4	2023	2023	NUM
admet-2403	213	5	)	)	PUNCT
admet-2403	213	6	1492	1492	NUM
admet-2403	213	7	.	.	PUNCT
admet-2403	214	1	https://doi.org/10.3390/molecules28031492	https://doi.org/10.3390/molecules28031492	PROPN
admet-2403	215	1	[	[	X
admet-2403	215	2	10	10	NUM
admet-2403	215	3	]	]	X
admet-2403	215	4	a.a	a.a	PROPN
admet-2403	215	5	.	.	PROPN
admet-2403	215	6	date	date	PROPN
admet-2403	215	7	,	,	PUNCT
admet-2403	215	8	m.s	m.s	PROPN
admet-2403	215	9	.	.	PROPN
admet-2403	215	10	nagarsenker	nagarsenker	PROPN
admet-2403	215	11	.	.	PUNCT
admet-2403	216	1	design	design	NOUN
admet-2403	216	2	and	and	CCONJ
admet-2403	216	3	evaluation	evaluation	NOUN
admet-2403	216	4	of	of	ADP
admet-2403	216	5	microemulsions	microemulsion	NOUN
admet-2403	216	6	for	for	ADP
admet-2403	216	7	improved	improve	VERB
admet-2403	216	8	parenteral	parenteral	ADJ
admet-2403	216	9	delivery	delivery	NOUN
admet-2403	216	10	of	of	ADP
admet-2403	216	11	propofol	propofol	NOUN
admet-2403	216	12	.	.	PUNCT
admet-2403	217	1	aaps	aap	NOUN
admet-2403	217	2	pharmscitech	pharmscitech	VERB
admet-2403	217	3	9	9	NUM
admet-2403	217	4	(	(	PUNCT
admet-2403	217	5	2008	2008	NUM
admet-2403	217	6	)	)	PUNCT
admet-2403	217	7	138	138	NUM
admet-2403	217	8	-	-	SYM
admet-2403	217	9	145	145	NUM
admet-2403	217	10	.	.	PUNCT
admet-2403	218	1	https://doi.org/10.1208/s12249-0079023-7	https://doi.org/10.1208/s12249-0079023-7	PROPN
admet-2403	219	1	[	[	X
admet-2403	219	2	11	11	NUM
admet-2403	219	3	]	]	X
admet-2403	219	4	t.d	t.d	PROPN
admet-2403	219	5	.	.	PROPN
admet-2403	219	6	egan	egan	PROPN
admet-2403	219	7	.	.	PUNCT
admet-2403	220	1	exploring	explore	VERB
admet-2403	220	2	the	the	DET
admet-2403	220	3	frontiers	frontier	NOUN
admet-2403	220	4	of	of	ADP
admet-2403	220	5	propofol	propofol	NOUN
admet-2403	220	6	formulation	formulation	NOUN
admet-2403	220	7	strategy	strategy	NOUN
admet-2403	220	8	:	:	PUNCT
admet-2403	220	9	is	be	AUX
admet-2403	220	10	there	there	PRON
admet-2403	220	11	life	life	NOUN
admet-2403	220	12	beyond	beyond	ADP
admet-2403	220	13	the	the	DET
admet-2403	220	14	milky	milky	ADJ
admet-2403	220	15	way	way	NOUN
admet-2403	220	16	.	.	PUNCT
admet-2403	221	1	british	british	ADJ
admet-2403	221	2	journal	journal	PROPN
admet-2403	221	3	of	of	ADP
admet-2403	221	4	anaesthesia	anaesthesia	PROPN
admet-2403	221	5	104	104	NUM
admet-2403	221	6	(	(	PUNCT
admet-2403	221	7	2010	2010	NUM
admet-2403	221	8	)	)	PUNCT
admet-2403	221	9	533	533	NUM
admet-2403	221	10	-	-	SYM
admet-2403	221	11	535	535	NUM
admet-2403	221	12	.	.	PUNCT
admet-2403	222	1	https://doi.org/10.1093/bja/aeq059	https://doi.org/10.1093/bja/aeq059	PROPN
admet-2403	223	1	[	[	X
admet-2403	223	2	12	12	NUM
admet-2403	223	3	]	]	PUNCT
admet-2403	223	4	w.	w.	PROPN
admet-2403	223	5	zhang	zhang	PROPN
admet-2403	223	6	,	,	PUNCT
admet-2403	223	7	j.	j.	PROPN
admet-2403	223	8	yang	yang	PROPN
admet-2403	223	9	,	,	PUNCT
admet-2403	223	10	j.	j.	PROPN
admet-2403	223	11	fan	fan	PROPN
admet-2403	223	12	,	,	PUNCT
admet-2403	223	13	b.	b.	PROPN
admet-2403	223	14	wang	wang	PROPN
admet-2403	223	15	,	,	PUNCT
admet-2403	223	16	y.	y.	PROPN
admet-2403	223	17	kang	kang	PROPN
admet-2403	223	18	,	,	PUNCT
admet-2403	223	19	j.	j.	PROPN
admet-2403	223	20	liu	liu	PROPN
admet-2403	223	21	,	,	PUNCT
admet-2403	223	22	w.	w.	PROPN
admet-2403	223	23	zhang	zhang	PROPN
admet-2403	223	24	,	,	PUNCT
admet-2403	223	25	t.	t.	PROPN
admet-2403	223	26	zhu	zhu	PROPN
admet-2403	223	27	.	.	PUNCT
admet-2403	224	1	an	an	DET
admet-2403	224	2	improved	improved	ADJ
admet-2403	224	3	water	water	NOUN
admet-2403	224	4	-	-	PUNCT
admet-2403	224	5	soluble	soluble	ADJ
admet-2403	224	6	prodrug	prodrug	NOUN
admet-2403	224	7	of	of	ADP
admet-2403	224	8	propofol	propofol	NOUN
admet-2403	224	9	with	with	ADP
admet-2403	224	10	high	high	ADJ
admet-2403	224	11	molecular	molecular	ADJ
admet-2403	224	12	utilization	utilization	NOUN
admet-2403	224	13	and	and	CCONJ
admet-2403	224	14	rapid	rapid	ADJ
admet-2403	224	15	onset	onset	NOUN
admet-2403	224	16	of	of	ADP
admet-2403	224	17	action	action	NOUN
admet-2403	224	18	.	.	PUNCT
admet-2403	225	1	european	european	ADJ
admet-2403	225	2	journal	journal	PROPN
admet-2403	225	3	of	of	ADP
admet-2403	225	4	pharmaceutical	pharmaceutical	PROPN
admet-2403	225	5	sciences	science	NOUN
admet-2403	225	6	127	127	NUM
admet-2403	225	7	(	(	PUNCT
admet-2403	225	8	2019	2019	NUM
admet-2403	225	9	)	)	PUNCT
admet-2403	225	10	9	9	NUM
admet-2403	225	11	-	-	SYM
admet-2403	225	12	13	13	NUM
admet-2403	225	13	.	.	PUNCT
admet-2403	226	1	https://doi.org/10.1016/j.ejps.2018.09.024	https://doi.org/10.1016/j.ejps.2018.09.024	NOUN
admet-2403	227	1	[	[	X
admet-2403	227	2	13	13	NUM
admet-2403	227	3	]	]	X
admet-2403	227	4	l.a	l.a	PROPN
admet-2403	227	5	.	.	PROPN
admet-2403	227	6	keller	keller	PROPN
admet-2403	227	7	,	,	PUNCT
admet-2403	227	8	o.	o.	PROPN
admet-2403	227	9	merkel	merkel	PROPN
admet-2403	227	10	,	,	PUNCT
admet-2403	227	11	a.	a.	PROPN
admet-2403	227	12	popp	popp	PROPN
admet-2403	227	13	.	.	PUNCT
admet-2403	228	1	intranasal	intranasal	ADJ
admet-2403	228	2	drug	drug	NOUN
admet-2403	228	3	delivery	delivery	NOUN
admet-2403	228	4	:	:	PUNCT
admet-2403	229	1	opportunities	opportunity	NOUN
admet-2403	229	2	and	and	CCONJ
admet-2403	229	3	toxicologic	toxicologic	ADJ
admet-2403	229	4	challenges	challenge	NOUN
admet-2403	229	5	during	during	ADP
admet-2403	229	6	drug	drug	NOUN
admet-2403	229	7	development	development	NOUN
admet-2403	229	8	.	.	PUNCT
admet-2403	230	1	drug	drug	NOUN
admet-2403	230	2	delivery	delivery	NOUN
admet-2403	230	3	and	and	CCONJ
admet-2403	230	4	translational	translational	ADJ
admet-2403	230	5	research	research	NOUN
admet-2403	230	6	12	12	NUM
admet-2403	230	7	(	(	PUNCT
admet-2403	230	8	2022	2022	NUM
admet-2403	230	9	)	)	PUNCT
admet-2403	230	10	735	735	NUM
admet-2403	230	11	-	-	SYM
admet-2403	230	12	757	757	NUM
admet-2403	230	13	.	.	PUNCT
admet-2403	231	1	https://doi.org/10.1007/s13346-020-00891-5	https://doi.org/10.1007/s13346-020-00891-5	NUM
admet-2403	232	1	[	[	X
admet-2403	232	2	14	14	NUM
admet-2403	232	3	]	]	X
admet-2403	232	4	l.	l.	PROPN
admet-2403	232	5	tiozzo	tiozzo	PROPN
admet-2403	232	6	fasiolo	fasiolo	PROPN
admet-2403	232	7	,	,	PUNCT
admet-2403	232	8	m.d	m.d	PROPN
admet-2403	232	9	.	.	PROPN
admet-2403	232	10	manniello	manniello	PROPN
admet-2403	232	11	,	,	PUNCT
admet-2403	232	12	e.	e.	PROPN
admet-2403	232	13	tratta	tratta	PROPN
admet-2403	232	14	,	,	PUNCT
admet-2403	232	15	f.	f.	PROPN
admet-2403	232	16	buttini	buttini	PROPN
admet-2403	232	17	,	,	PUNCT
admet-2403	232	18	a.	a.	PROPN
admet-2403	232	19	rossi	rossi	PROPN
admet-2403	232	20	,	,	PUNCT
admet-2403	232	21	f.	f.	PROPN
admet-2403	232	22	sonvico	sonvico	PROPN
admet-2403	232	23	,	,	PUNCT
admet-2403	232	24	f.	f.	PROPN
admet-2403	232	25	bortolotti	bortolotti	PROPN
admet-2403	232	26	,	,	PUNCT
admet-2403	232	27	p.	p.	PROPN
admet-2403	232	28	russo	russo	PROPN
admet-2403	232	29	,	,	PUNCT
admet-2403	232	30	g.	g.	PROPN
admet-2403	232	31	colombo	colombo	PROPN
admet-2403	232	32	.	.	PUNCT
admet-2403	233	1	opportunity	opportunity	NOUN
admet-2403	233	2	and	and	CCONJ
admet-2403	233	3	challenges	challenge	NOUN
admet-2403	233	4	of	of	ADP
admet-2403	233	5	nasal	nasal	ADJ
admet-2403	233	6	powders	powder	NOUN
admet-2403	233	7	:	:	PUNCT
admet-2403	233	8	drug	drug	NOUN
admet-2403	233	9	formulation	formulation	NOUN
admet-2403	233	10	and	and	CCONJ
admet-2403	233	11	delivery	delivery	NOUN
admet-2403	233	12	.	.	PUNCT
admet-2403	234	1	european	european	ADJ
admet-2403	234	2	journal	journal	PROPN
admet-2403	234	3	of	of	ADP
admet-2403	234	4	pharmaceutical	pharmaceutical	PROPN
admet-2403	234	5	sciences	science	NOUN
admet-2403	234	6	113	113	NUM
admet-2403	234	7	(	(	PUNCT
admet-2403	234	8	2018	2018	NUM
admet-2403	234	9	)	)	PUNCT
admet-2403	234	10	2	2	NUM
admet-2403	234	11	-	-	SYM
admet-2403	234	12	17	17	NUM
admet-2403	234	13	.	.	PUNCT
admet-2403	235	1	https://doi.org/10.1016/j.ejps.2017.09.027	https://doi.org/10.1016/j.ejps.2017.09.027	PROPN
admet-2403	236	1	[	[	X
admet-2403	236	2	15	15	NUM
admet-2403	236	3	]	]	X
admet-2403	236	4	s.	s.	PROPN
admet-2403	236	5	serra	serra	PROPN
admet-2403	236	6	,	,	PUNCT
admet-2403	236	7	m.d	m.d	PROPN
admet-2403	236	8	.	.	PROPN
admet-2403	236	9	spampinato	spampinato	PROPN
admet-2403	236	10	,	,	PUNCT
admet-2403	236	11	a.	a.	PROPN
admet-2403	236	12	riccardi	riccardi	PROPN
admet-2403	236	13	,	,	PUNCT
admet-2403	236	14	m.	m.	NOUN
admet-2403	236	15	guarino	guarino	PROPN
admet-2403	236	16	,	,	PUNCT
admet-2403	236	17	r.	r.	PROPN
admet-2403	236	18	pavasini	pavasini	PROPN
admet-2403	236	19	,	,	PUNCT
admet-2403	236	20	a.	a.	NOUN
admet-2403	236	21	fabbri	fabbri	NOUN
admet-2403	236	22	,	,	PUNCT
admet-2403	236	23	f.	f.	PROPN
admet-2403	236	24	de	de	PROPN
admet-2403	236	25	iaco	iaco	PROPN
admet-2403	236	26	.	.	PUNCT
admet-2403	237	1	intranasal	intranasal	ADJ
admet-2403	237	2	fentanyl	fentanyl	NOUN
admet-2403	237	3	for	for	ADP
admet-2403	237	4	acute	acute	ADJ
admet-2403	237	5	pain	pain	NOUN
admet-2403	237	6	management	management	NOUN
admet-2403	237	7	in	in	ADP
admet-2403	237	8	children	child	NOUN
admet-2403	237	9	,	,	PUNCT
admet-2403	237	10	adults	adult	NOUN
admet-2403	237	11	and	and	CCONJ
admet-2403	237	12	elderly	elderly	ADJ
admet-2403	237	13	patients	patient	NOUN
admet-2403	237	14	in	in	ADP
admet-2403	237	15	the	the	DET
admet-2403	237	16	prehospital	prehospital	NOUN
admet-2403	237	17	emergency	emergency	NOUN
admet-2403	237	18	service	service	NOUN
admet-2403	237	19	and	and	CCONJ
admet-2403	237	20	in	in	ADP
admet-2403	237	21	the	the	DET
admet-2403	237	22	emergency	emergency	NOUN
admet-2403	237	23	department	department	NOUN
admet-2403	237	24	:	:	PUNCT
admet-2403	237	25	a	a	DET
admet-2403	237	26	systematic	systematic	ADJ
admet-2403	237	27	review	review	NOUN
admet-2403	237	28	.	.	PUNCT
admet-2403	238	1	journal	journal	NOUN
admet-2403	238	2	of	of	ADP
admet-2403	238	3	clinical	clinical	ADJ
admet-2403	238	4	medicine	medicine	NOUN
admet-2403	238	5	12	12	NUM
admet-2403	238	6	(	(	PUNCT
admet-2403	238	7	2023	2023	NUM
admet-2403	238	8	)	)	PUNCT
admet-2403	238	9	2609	2609	NUM
admet-2403	238	10	.	.	PUNCT
admet-2403	239	1	https://doi.org/10.3390/jcm12072609	https://doi.org/10.3390/jcm12072609	NOUN
admet-2403	239	2	[	[	X
admet-2403	239	3	16	16	NUM
admet-2403	239	4	]	]	PUNCT
admet-2403	239	5	v.	v.	PROPN
admet-2403	239	6	pansini	pansini	PROPN
admet-2403	239	7	,	,	PUNCT
admet-2403	239	8	a.	a.	NOUN
admet-2403	239	9	curatola	curatola	PROPN
admet-2403	239	10	,	,	PUNCT
admet-2403	239	11	a.	a.	NOUN
admet-2403	239	12	gatto	gatto	PROPN
admet-2403	239	13	,	,	PUNCT
admet-2403	239	14	i.	i.	PROPN
admet-2403	239	15	lazzareschi	lazzareschi	PROPN
admet-2403	239	16	,	,	PUNCT
admet-2403	239	17	a.	a.	NOUN
admet-2403	239	18	ruggiero	ruggiero	PROPN
admet-2403	239	19	,	,	PUNCT
admet-2403	239	20	a.	a.	PROPN
admet-2403	239	21	chiaretti	chiaretti	PROPN
admet-2403	239	22	.	.	PUNCT
admet-2403	240	1	intranasal	intranasal	ADJ
admet-2403	240	2	drugs	drug	NOUN
admet-2403	240	3	for	for	ADP
admet-2403	240	4	analgesia	analgesia	NOUN
admet-2403	240	5	and	and	CCONJ
admet-2403	240	6	sedation	sedation	NOUN
admet-2403	240	7	in	in	ADP
admet-2403	240	8	children	child	NOUN
admet-2403	240	9	admitted	admit	VERB
admet-2403	240	10	to	to	ADP
admet-2403	240	11	pediatric	pediatric	ADJ
admet-2403	240	12	emergency	emergency	NOUN
admet-2403	240	13	department	department	NOUN
admet-2403	240	14	:	:	PUNCT
admet-2403	240	15	a	a	DET
admet-2403	240	16	narrative	narrative	NOUN
admet-2403	240	17	review	review	NOUN
admet-2403	240	18	.	.	PUNCT
admet-2403	241	1	annals	annal	NOUN
admet-2403	241	2	of	of	ADP
admet-2403	241	3	translational	translational	ADJ
admet-2403	241	4	medicine	medicine	NOUN
admet-2403	241	5	9	9	NUM
admet-2403	241	6	(	(	PUNCT
admet-2403	241	7	2021	2021	NUM
admet-2403	241	8	)	)	PUNCT
admet-2403	241	9	189	189	NUM
admet-2403	241	10	.	.	PUNCT
admet-2403	241	11	https://doi.org/10.21037/atm-20-5177	https://doi.org/10.21037/atm-20-5177	PROPN
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admet-2403	242	2	17	17	NUM
admet-2403	242	3	]	]	PUNCT
admet-2403	242	4	a.	a.	NOUN
admet-2403	242	5	riccardi	riccardi	PROPN
admet-2403	242	6	,	,	PUNCT
admet-2403	242	7	m.	m.	NOUN
admet-2403	242	8	guarino	guarino	PROPN
admet-2403	242	9	,	,	PUNCT
admet-2403	242	10	s.	s.	PROPN
admet-2403	242	11	serra	serra	PROPN
admet-2403	242	12	,	,	PUNCT
admet-2403	242	13	m.d	m.d	PROPN
admet-2403	242	14	.	.	PROPN
admet-2403	242	15	spampinato	spampinato	PROPN
admet-2403	242	16	,	,	PUNCT
admet-2403	242	17	s.	s.	PROPN
admet-2403	242	18	vanni	vanni	PROPN
admet-2403	242	19	,	,	PUNCT
admet-2403	242	20	d.	d.	PROPN
admet-2403	242	21	shiffer	shiffer	PROPN
admet-2403	242	22	,	,	PUNCT
admet-2403	242	23	a.	a.	NOUN
admet-2403	242	24	voza	voza	NOUN
admet-2403	242	25	,	,	PUNCT
admet-2403	242	26	a.	a.	NOUN
admet-2403	242	27	fabbri	fabbri	NOUN
admet-2403	242	28	,	,	PUNCT
admet-2403	242	29	f.	f.	PROPN
admet-2403	242	30	de	de	PROPN
admet-2403	242	31	iaco	iaco	PROPN
admet-2403	242	32	.	.	PUNCT
admet-2403	243	1	narrative	narrative	PROPN
admet-2403	243	2	review	review	PROPN
admet-2403	243	3	:	:	PUNCT
admet-2403	243	4	low	low	ADJ
admet-2403	243	5	-	-	PUNCT
admet-2403	243	6	dose	dose	NOUN
admet-2403	243	7	ketamine	ketamine	NOUN
admet-2403	243	8	for	for	ADP
admet-2403	243	9	pain	pain	NOUN
admet-2403	243	10	management	management	NOUN
admet-2403	243	11	.	.	PUNCT
admet-2403	244	1	journal	journal	NOUN
admet-2403	244	2	of	of	ADP
admet-2403	244	3	clinical	clinical	ADJ
admet-2403	244	4	medicine	medicine	NOUN
admet-2403	244	5	12	12	NUM
admet-2403	244	6	(	(	PUNCT
admet-2403	244	7	2023	2023	NUM
admet-2403	244	8	)	)	PUNCT
admet-2403	244	9	3256	3256	NUM
admet-2403	244	10	.	.	PUNCT
admet-2403	245	1	https://doi.org/10.3390/jcm12093256	https://doi.org/10.3390/jcm12093256	PUNCT
admet-2403	246	1	[	[	X
admet-2403	246	2	18	18	NUM
admet-2403	246	3	]	]	X
admet-2403	246	4	f.	f.	NOUN
admet-2403	246	5	cossovel	cossovel	PROPN
admet-2403	246	6	,	,	PUNCT
admet-2403	246	7	a.	a.	NOUN
admet-2403	246	8	trombetta	trombetta	PROPN
admet-2403	246	9	,	,	PUNCT
admet-2403	246	10	a.	a.	NOUN
admet-2403	246	11	ramondo	ramondo	PROPN
admet-2403	246	12	,	,	PUNCT
admet-2403	246	13	g.	g.	PROPN
admet-2403	246	14	riccio	riccio	PROPN
admet-2403	246	15	,	,	PUNCT
admet-2403	246	16	l.	l.	PROPN
admet-2403	246	17	ronfani	ronfani	PROPN
admet-2403	246	18	,	,	PUNCT
admet-2403	246	19	a.	a.	NOUN
admet-2403	246	20	saccari	saccari	PROPN
admet-2403	246	21	,	,	PUNCT
admet-2403	246	22	g.	g.	PROPN
admet-2403	246	23	cozzi	cozzi	PROPN
admet-2403	246	24	,	,	PUNCT
admet-2403	246	25	e.	e.	PROPN
admet-2403	246	26	barbi	barbi	PROPN
admet-2403	246	27	.	.	PROPN
admet-2403	247	1	intranasal	intranasal	PROPN
admet-2403	247	2	dexmedetomidine	dexmedetomidine	PROPN
admet-2403	247	3	and	and	CCONJ
admet-2403	247	4	intranasal	intranasal	PROPN
admet-2403	247	5	ketamine	ketamine	PROPN
admet-2403	247	6	association	association	PROPN
admet-2403	247	7	allows	allow	VERB
admet-2403	247	8	shorter	short	ADJ
admet-2403	247	9	induction	induction	NOUN
admet-2403	247	10	time	time	NOUN
admet-2403	247	11	for	for	ADP
admet-2403	247	12	pediatric	pediatric	ADJ
admet-2403	247	13	sedation	sedation	NOUN
admet-2403	247	14	compared	compare	VERB
admet-2403	247	15	to	to	ADP
admet-2403	247	16	intranasal	intranasal	ADJ
admet-2403	247	17	dexmedetomidine	dexmedetomidine	NOUN
admet-2403	247	18	and	and	CCONJ
admet-2403	247	19	oral	oral	ADJ
admet-2403	247	20	midazolam	midazolam	PROPN
admet-2403	247	21	.	.	PUNCT
admet-2403	248	1	italian	italian	ADJ
admet-2403	248	2	journal	journal	NOUN
admet-2403	248	3	of	of	ADP
admet-2403	248	4	pediatrics	pediatric	NOUN
admet-2403	248	5	48	48	NUM
admet-2403	248	6	(	(	PUNCT
admet-2403	248	7	2022	2022	NUM
admet-2403	248	8	)	)	PUNCT
admet-2403	248	9	5	5	NUM
admet-2403	248	10	.	.	X
admet-2403	249	1	https://doi.org/10.1186/s13052-021-01196-0	https://doi.org/10.1186/s13052-021-01196-0	NUM
admet-2403	249	2	[	[	X
admet-2403	249	3	19	19	NUM
admet-2403	249	4	]	]	SYM
admet-2403	249	5	s.b	s.b	PROPN
admet-2403	249	6	.	.	PROPN
admet-2403	249	7	shrewsbury	shrewsbury	PROPN
admet-2403	249	8	.	.	PUNCT
admet-2403	250	1	the	the	DET
admet-2403	250	2	upper	upper	ADJ
admet-2403	250	3	nasal	nasal	PROPN
admet-2403	250	4	space	space	NOUN
admet-2403	250	5	:	:	PUNCT
admet-2403	250	6	option	option	NOUN
admet-2403	250	7	for	for	ADP
admet-2403	250	8	systemic	systemic	ADJ
admet-2403	250	9	drug	drug	NOUN
admet-2403	250	10	delivery	delivery	NOUN
admet-2403	250	11	,	,	PUNCT
admet-2403	250	12	mucosal	mucosal	ADJ
admet-2403	250	13	vaccines	vaccine	NOUN
admet-2403	250	14	and	and	CCONJ
admet-2403	250	15	"	"	PUNCT
admet-2403	250	16	nose	nose	NOUN
admet-2403	250	17	-	-	PUNCT
admet-2403	250	18	to	to	ADP
admet-2403	250	19	-	-	PUNCT
admet-2403	250	20	brain	brain	NOUN
admet-2403	250	21	"	"	PUNCT
admet-2403	250	22	.	.	PUNCT
admet-2403	251	1	pharmaceutics	pharmaceutic	NOUN
admet-2403	251	2	15	15	NUM
admet-2403	251	3	(	(	PUNCT
admet-2403	251	4	2023	2023	NUM
admet-2403	251	5	)	)	PUNCT
admet-2403	251	6	1720	1720	NUM
admet-2403	251	7	.	.	PUNCT
admet-2403	252	1	https://doi.org/10.3390/pharmaceutics15061720	https://doi.org/10.3390/pharmaceutics15061720	NOUN
admet-2403	252	2	[	[	X
admet-2403	252	3	20	20	NUM
admet-2403	252	4	]	]	SYM
admet-2403	252	5	i.f	i.f	PROPN
admet-2403	252	6	.	.	PROPN
admet-2403	252	7	uchegbu	uchegbu	PROPN
admet-2403	252	8	,	,	PUNCT
admet-2403	252	9	m.c	m.c	PROPN
admet-2403	252	10	.	.	PROPN
admet-2403	252	11	jones	jones	PROPN
admet-2403	252	12	,	,	PUNCT
admet-2403	252	13	f.	f.	PROPN
admet-2403	252	14	corrente	corrente	PROPN
admet-2403	252	15	,	,	PUNCT
admet-2403	252	16	l.	l.	PROPN
admet-2403	252	17	godfrey	godfrey	PROPN
admet-2403	252	18	,	,	PUNCT
admet-2403	252	19	d.	d.	PROPN
admet-2403	252	20	laghezza	laghezza	PROPN
admet-2403	252	21	,	,	PUNCT
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admet-2403	252	23	carafa	carafa	PROPN
admet-2403	252	24	,	,	PUNCT
admet-2403	252	25	p.	p.	NOUN
admet-2403	252	26	holm	holm	PROPN
admet-2403	252	27	,	,	PUNCT
admet-2403	252	28	a.g	a.g	PROPN
admet-2403	252	29	.	.	PROPN
admet-2403	252	30	schätzlein	schätzlein	PROPN
admet-2403	252	31	.	.	PUNCT
admet-2403	253	1	the	the	DET
admet-2403	253	2	oral	oral	ADJ
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admet-2403	253	4	intranasal	intranasal	ADJ
admet-2403	253	5	delivery	delivery	NOUN
admet-2403	253	6	of	of	ADP
admet-2403	253	7	propofol	propofol	NOUN
admet-2403	253	8	using	use	VERB
admet-2403	253	9	chitosan	chitosan	NOUN
admet-2403	253	10	amphiphile	amphiphile	ADP
admet-2403	253	11	nanoparticles	nanoparticle	NOUN
admet-2403	253	12	.	.	PUNCT
admet-2403	254	1	pharmaceutical	pharmaceutical	ADJ
admet-2403	254	2	nanotechnology	nanotechnology	NOUN
admet-2403	254	3	2	2	NUM
admet-2403	254	4	(	(	PUNCT
admet-2403	254	5	2014	2014	NUM
admet-2403	254	6	)	)	PUNCT
admet-2403	254	7	.	.	PUNCT
admet-2403	255	1	https://doi.org/10.2174/2211738502666140616184703	https://doi.org/10.2174/2211738502666140616184703	PUNCT
admet-2403	255	2	[	[	X
admet-2403	255	3	21	21	NUM
admet-2403	255	4	]	]	PUNCT
admet-2403	255	5	a.	a.	NOUN
admet-2403	255	6	haasbroek	haasbroek	PROPN
admet-2403	255	7	-	-	PUNCT
admet-2403	255	8	pheiffer	pheiffer	NOUN
admet-2403	255	9	,	,	PUNCT
admet-2403	255	10	s.	s.	PROPN
admet-2403	255	11	van	van	PROPN
admet-2403	255	12	niekerk	niekerk	PROPN
admet-2403	255	13	,	,	PUNCT
admet-2403	255	14	f.	f.	PROPN
admet-2403	255	15	van	van	PROPN
admet-2403	255	16	der	der	PROPN
admet-2403	255	17	kooy	kooy	NOUN
admet-2403	255	18	,	,	PUNCT
admet-2403	255	19	t.	t.	NOUN
admet-2403	255	20	cloete	cloete	NOUN
admet-2403	255	21	,	,	PUNCT
admet-2403	255	22	j.	j.	PROPN
admet-2403	255	23	steenekamp	steenekamp	PROPN
admet-2403	255	24	,	,	PUNCT
admet-2403	255	25	j.	j.	PROPN
admet-2403	255	26	hamman	hamman	PROPN
admet-2403	255	27	.	.	PUNCT
admet-2403	256	1	in	in	ADP
admet-2403	256	2	vitro	vitro	X
admet-2403	256	3	and	and	CCONJ
admet-2403	256	4	ex	ex	ADJ
admet-2403	256	5	vivo	vivo	ADJ
admet-2403	256	6	experimental	experimental	ADJ
admet-2403	256	7	models	model	NOUN
admet-2403	256	8	for	for	ADP
admet-2403	256	9	evaluation	evaluation	NOUN
admet-2403	256	10	of	of	ADP
admet-2403	256	11	intranasal	intranasal	ADJ
admet-2403	256	12	systemic	systemic	ADJ
admet-2403	256	13	drug	drug	NOUN
admet-2403	256	14	delivery	delivery	NOUN
admet-2403	256	15	as	as	ADV
admet-2403	256	16	well	well	ADV
admet-2403	256	17	as	as	ADP
admet-2403	256	18	direct	direct	ADJ
admet-2403	256	19	nose	nose	NOUN
admet-2403	256	20	-	-	PUNCT
admet-2403	256	21	to	to	ADP
admet-2403	256	22	-	-	PUNCT
admet-2403	256	23	brain	brain	NOUN
admet-2403	256	24	drug	drug	NOUN
admet-2403	256	25	delivery	delivery	NOUN
admet-2403	256	26	.	.	PUNCT
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admet-2403	257	2	and	and	CCONJ
admet-2403	257	3	drug	drug	NOUN
admet-2403	257	4	disposition	disposition	NOUN
admet-2403	257	5	44	44	NUM
admet-2403	257	6	(	(	PUNCT
admet-2403	257	7	2023	2023	NUM
admet-2403	257	8	)	)	PUNCT
admet-2403	257	9	94	94	NUM
admet-2403	257	10	-	-	SYM
admet-2403	257	11	112	112	NUM
admet-2403	257	12	.	.	PUNCT
admet-2403	258	1	https://doi.org/10.1002/bdd.2348	https://doi.org/10.1002/bdd.2348	NOUN
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admet-2403	258	3	https://doi.org/10.3390/children8080648	https://doi.org/10.3390/children8080648	VERB
admet-2403	258	4	https://doi.org/10.3390/molecules28031492	https://doi.org/10.3390/molecules28031492	PROPN
admet-2403	258	5	https://doi.org/10.1208/s12249-007-9023-7	https://doi.org/10.1208/s12249-007-9023-7	PROPN
admet-2403	258	6	https://doi.org/10.1208/s12249-007-9023-7	https://doi.org/10.1208/s12249-007-9023-7	PROPN
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admet-2403	258	8	https://doi.org/10.1016/j.ejps.2018.09.024	https://doi.org/10.1016/j.ejps.2018.09.024	PROPN
admet-2403	258	9	https://doi.org/10.1007/s13346-020-00891-5	https://doi.org/10.1007/s13346-020-00891-5	NUM
admet-2403	258	10	https://doi.org/10.1016/j.ejps.2017.09.027	https://doi.org/10.1016/j.ejps.2017.09.027	PROPN
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admet-2403	258	12	https://doi.org/10.21037/atm-20-5177	https://doi.org/10.21037/atm-20-5177	X
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admet-2403	258	14	https://doi.org/10.1186/s13052-021-01196-0	https://doi.org/10.1186/s13052-021-01196-0	NUM
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admet-2403	258	18	admet	admet	PROPN
admet-2403	258	19	&	&	CCONJ
admet-2403	258	20	dmpk	dmpk	PROPN
admet-2403	258	21	12(5	12(5	NUM
admet-2403	258	22	)	)	PUNCT
admet-2403	258	23	(	(	PUNCT
admet-2403	258	24	2024	2024	NUM
admet-2403	258	25	)	)	PUNCT
admet-2403	258	26	759	759	NUM
admet-2403	258	27	-	-	SYM
admet-2403	258	28	768	768	NUM
admet-2403	258	29	a	a	DET
admet-2403	258	30	proof	proof	NOUN
admet-2403	258	31	-	-	PUNCT
admet-2403	258	32	of	of	ADP
admet-2403	258	33	-	-	PUNCT
admet-2403	258	34	concept	concept	NOUN
admet-2403	258	35	study	study	NOUN
admet-2403	258	36	for	for	ADP
admet-2403	258	37	outpatient	outpatient	NOUN
admet-2403	258	38	light	light	ADJ
admet-2403	258	39	sedation	sedation	NOUN
admet-2403	258	40	via	via	ADP
admet-2403	258	41	nasal	nasal	PROPN
admet-2403	258	42	route	route	PROPN
admet-2403	258	43	doi	doi	PROPN
admet-2403	258	44	:	:	PUNCT
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admet-2403	258	46	767	767	NUM
admet-2403	258	47	[	[	SYM
admet-2403	258	48	22	22	NUM
admet-2403	258	49	]	]	X
admet-2403	258	50	f.	f.	PROPN
admet-2403	258	51	bortolotti	bortolotti	PROPN
admet-2403	258	52	,	,	PUNCT
admet-2403	258	53	a.g	a.g	PROPN
admet-2403	258	54	.	.	PROPN
admet-2403	258	55	balducci	balducci	PROPN
admet-2403	258	56	,	,	PUNCT
admet-2403	258	57	f.	f.	PROPN
admet-2403	258	58	sonvico	sonvico	PROPN
admet-2403	258	59	,	,	PUNCT
admet-2403	258	60	p.	p.	PROPN
admet-2403	258	61	russo	russo	PROPN
admet-2403	258	62	,	,	PUNCT
admet-2403	258	63	g.	g.	PROPN
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admet-2403	258	65	.	.	PUNCT
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admet-2403	259	6	across	across	ADP
admet-2403	259	7	rabbit	rabbit	NOUN
admet-2403	259	8	nasal	nasal	PROPN
admet-2403	259	9	mucosa	mucosa	NOUN
admet-2403	259	10	from	from	ADP
admet-2403	259	11	liquid	liquid	ADJ
admet-2403	259	12	nasal	nasal	NOUN
admet-2403	259	13	sprays	spray	NOUN
admet-2403	259	14	:	:	PUNCT
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admet-2403	259	16	enhancing	enhance	VERB
admet-2403	259	17	effect	effect	NOUN
admet-2403	259	18	of	of	ADP
admet-2403	259	19	potassium	potassium	NOUN
admet-2403	259	20	sorbate	sorbate	NOUN
admet-2403	259	21	.	.	PUNCT
admet-2403	260	1	european	european	ADJ
admet-2403	260	2	journal	journal	PROPN
admet-2403	260	3	of	of	ADP
admet-2403	260	4	pharmaceutical	pharmaceutical	PROPN
admet-2403	260	5	sciences	science	NOUN
admet-2403	260	6	37	37	NUM
admet-2403	260	7	(	(	PUNCT
admet-2403	260	8	2009	2009	NUM
admet-2403	260	9	)	)	PUNCT
admet-2403	260	10	36	36	NUM
admet-2403	260	11	-	-	SYM
admet-2403	260	12	42	42	NUM
admet-2403	260	13	.	.	PUNCT
admet-2403	261	1	https://doi.org/10.1016/j.ejps.2008.12.015	https://doi.org/10.1016/j.ejps.2008.12.015	NOUN
admet-2403	261	2	[	[	X
admet-2403	261	3	23	23	NUM
admet-2403	261	4	]	]	X
admet-2403	261	5	a.g	a.g	PROPN
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admet-2403	261	8	,	,	PUNCT
admet-2403	261	9	l.	l.	PROPN
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admet-2403	261	11	,	,	PUNCT
admet-2403	261	12	f.	f.	PROPN
admet-2403	261	13	bortolotti	bortolotti	PROPN
admet-2403	261	14	,	,	PUNCT
admet-2403	261	15	c.	c.	PROPN
admet-2403	261	16	nastruzzi	nastruzzi	PROPN
admet-2403	261	17	,	,	PUNCT
admet-2403	261	18	p.	p.	NOUN
admet-2403	261	19	colombo	colombo	NOUN
admet-2403	261	20	,	,	PUNCT
admet-2403	261	21	f.	f.	PROPN
admet-2403	261	22	sonvico	sonvico	PROPN
admet-2403	261	23	,	,	PUNCT
admet-2403	261	24	p.	p.	PROPN
admet-2403	261	25	russo	russo	PROPN
admet-2403	261	26	,	,	PUNCT
admet-2403	261	27	g.	g.	PROPN
admet-2403	261	28	colombo	colombo	PROPN
admet-2403	261	29	.	.	PUNCT
admet-2403	262	1	antidiuretic	antidiuretic	ADJ
admet-2403	262	2	effect	effect	NOUN
admet-2403	262	3	of	of	ADP
admet-2403	262	4	desmopressin	desmopressin	NOUN
admet-2403	262	5	chimera	chimera	NOUN
admet-2403	262	6	agglomerates	agglomerate	NOUN
admet-2403	262	7	by	by	ADP
admet-2403	262	8	nasal	nasal	PROPN
admet-2403	262	9	administration	administration	PROPN
admet-2403	262	10	in	in	ADP
admet-2403	262	11	rats	rat	NOUN
admet-2403	262	12	.	.	PUNCT
admet-2403	263	1	international	international	ADJ
admet-2403	263	2	journal	journal	PROPN
admet-2403	263	3	of	of	ADP
admet-2403	263	4	pharmaceutics	pharmaceutic	NOUN
admet-2403	263	5	440	440	NUM
admet-2403	263	6	(	(	PUNCT
admet-2403	263	7	2013	2013	NUM
admet-2403	263	8	)	)	PUNCT
admet-2403	263	9	154	154	NUM
admet-2403	263	10	-	-	SYM
admet-2403	263	11	160	160	NUM
admet-2403	263	12	.	.	PUNCT
admet-2403	264	1	https://doi.org/10.1016/j.ijpharm.2012.09.049	https://doi.org/10.1016/j.ijpharm.2012.09.049	PROPN
admet-2403	264	2	[	[	X
admet-2403	264	3	24	24	NUM
admet-2403	264	4	]	]	X
admet-2403	264	5	g.	g.	PROPN
admet-2403	264	6	colombo	colombo	PROPN
admet-2403	264	7	,	,	PUNCT
admet-2403	264	8	f.	f.	PROPN
admet-2403	264	9	bortolotti	bortolotti	PROPN
admet-2403	264	10	,	,	PUNCT
admet-2403	264	11	v.	v.	ADP
admet-2403	264	12	chiapponi	chiapponi	PROPN
admet-2403	264	13	,	,	PUNCT
admet-2403	264	14	f.	f.	PROPN
admet-2403	264	15	buttini	buttini	PROPN
admet-2403	264	16	,	,	PUNCT
admet-2403	264	17	f.	f.	PROPN
admet-2403	264	18	sonvico	sonvico	PROPN
admet-2403	264	19	,	,	PUNCT
admet-2403	264	20	r.	r.	PROPN
admet-2403	264	21	invernizzi	invernizzi	PROPN
admet-2403	264	22	,	,	PUNCT
admet-2403	264	23	f.	f.	PROPN
admet-2403	264	24	quaglia	quaglia	PROPN
admet-2403	264	25	,	,	PUNCT
admet-2403	264	26	c.	c.	PROPN
admet-2403	264	27	danesino	danesino	PROPN
admet-2403	264	28	,	,	PUNCT
admet-2403	264	29	f.	f.	PROPN
admet-2403	264	30	pagella	pagella	PROPN
admet-2403	264	31	,	,	PUNCT
admet-2403	264	32	p.	p.	PROPN
admet-2403	264	33	russo	russo	PROPN
admet-2403	264	34	,	,	PUNCT
admet-2403	264	35	r.	r.	PROPN
admet-2403	264	36	bettini	bettini	PROPN
admet-2403	264	37	,	,	PUNCT
admet-2403	264	38	p.	p.	NOUN
admet-2403	264	39	colombo	colombo	NOUN
admet-2403	264	40	,	,	PUNCT
admet-2403	264	41	a.	a.	PROPN
admet-2403	264	42	rossi	rossi	PROPN
admet-2403	264	43	.	.	PUNCT
admet-2403	265	1	nasal	nasal	PROPN
admet-2403	265	2	powders	powder	NOUN
admet-2403	265	3	of	of	ADP
admet-2403	265	4	thalidomide	thalidomide	NOUN
admet-2403	265	5	for	for	ADP
admet-2403	265	6	local	local	ADJ
admet-2403	265	7	treatment	treatment	NOUN
admet-2403	265	8	of	of	ADP
admet-2403	265	9	nose	nose	NOUN
admet-2403	265	10	bleeding	bleed	VERB
admet-2403	265	11	in	in	ADP
admet-2403	265	12	persons	person	NOUN
admet-2403	265	13	affected	affect	VERB
admet-2403	265	14	by	by	ADP
admet-2403	265	15	hereditary	hereditary	ADJ
admet-2403	265	16	hemorrhagic	hemorrhagic	NOUN
admet-2403	265	17	telangiectasia	telangiectasia	NOUN
admet-2403	265	18	.	.	PUNCT
admet-2403	266	1	international	international	ADJ
admet-2403	266	2	journal	journal	PROPN
admet-2403	266	3	of	of	ADP
admet-2403	266	4	pharmaceutics	pharmaceutic	NOUN
admet-2403	266	5	514	514	NUM
admet-2403	266	6	(	(	PUNCT
admet-2403	266	7	2016	2016	NUM
admet-2403	266	8	)	)	PUNCT
admet-2403	266	9	229	229	NUM
admet-2403	266	10	-	-	SYM
admet-2403	266	11	237	237	NUM
admet-2403	266	12	.	.	PUNCT
admet-2403	267	1	https://doi.org/10.1016/j.ijpharm.2016.07.002	https://doi.org/10.1016/j.ijpharm.2016.07.002	VERB
admet-2403	267	2	[	[	X
admet-2403	267	3	25	25	NUM
admet-2403	267	4	]	]	PUNCT
admet-2403	267	5	l.	l.	PROPN
admet-2403	267	6	tiozzo	tiozzo	PROPN
admet-2403	267	7	fasiolo	fasiolo	PROPN
admet-2403	267	8	,	,	PUNCT
admet-2403	267	9	m.d	m.d	PROPN
admet-2403	267	10	.	.	PROPN
admet-2403	267	11	manniello	manniello	PROPN
admet-2403	267	12	,	,	PUNCT
admet-2403	267	13	s.	s.	PROPN
admet-2403	267	14	banella	banella	PROPN
admet-2403	267	15	,	,	PUNCT
admet-2403	267	16	l.	l.	PROPN
admet-2403	267	17	napoli	napoli	PROPN
admet-2403	267	18	,	,	PUNCT
admet-2403	267	19	f.	f.	PROPN
admet-2403	267	20	bortolotti	bortolotti	PROPN
admet-2403	267	21	,	,	PUNCT
admet-2403	267	22	e.	e.	PROPN
admet-2403	267	23	quarta	quarta	PROPN
admet-2403	267	24	,	,	PUNCT
admet-2403	267	25	p.	p.	NOUN
admet-2403	267	26	colombo	colombo	NOUN
admet-2403	267	27	,	,	PUNCT
admet-2403	267	28	e.	e.	PROPN
admet-2403	267	29	balafas	balafas	PROPN
admet-2403	267	30	,	,	PUNCT
admet-2403	267	31	n.	n.	PROPN
admet-2403	267	32	kostomitsopoulos	kostomitsopoulos	PROPN
admet-2403	267	33	,	,	PUNCT
admet-2403	267	34	d.m	d.m	PROPN
admet-2403	267	35	.	.	PROPN
admet-2403	267	36	rekkas	rekkas	PROPN
admet-2403	267	37	,	,	PUNCT
admet-2403	267	38	g.	g.	PROPN
admet-2403	267	39	valsami	valsami	PROPN
admet-2403	267	40	,	,	PUNCT
admet-2403	267	41	p.	p.	NOUN
admet-2403	267	42	papakyriakopoulou	papakyriakopoulou	PROPN
admet-2403	267	43	,	,	PUNCT
admet-2403	267	44	g.	g.	PROPN
admet-2403	267	45	colombo	colombo	PROPN
admet-2403	267	46	,	,	PUNCT
admet-2403	267	47	p.	p.	PROPN
admet-2403	267	48	russo	russo	PROPN
admet-2403	267	49	.	.	PUNCT
admet-2403	268	1	flurbiprofen	flurbiprofen	NOUN
admet-2403	268	2	sodium	sodium	NOUN
admet-2403	268	3	microparticles	microparticle	NOUN
admet-2403	268	4	and	and	CCONJ
admet-2403	268	5	soft	soft	ADJ
admet-2403	268	6	pellets	pellet	NOUN
admet-2403	268	7	for	for	ADP
admet-2403	268	8	nose	nose	NOUN
admet-2403	268	9	-	-	PUNCT
admet-2403	268	10	to	to	ADP
admet-2403	268	11	-	-	PUNCT
admet-2403	268	12	brain	brain	NOUN
admet-2403	268	13	delivery	delivery	NOUN
admet-2403	268	14	:	:	PUNCT
admet-2403	268	15	serum	serum	NOUN
admet-2403	268	16	and	and	CCONJ
admet-2403	268	17	brain	brain	NOUN
admet-2403	268	18	levels	level	NOUN
admet-2403	268	19	in	in	ADP
admet-2403	268	20	rats	rat	NOUN
admet-2403	268	21	after	after	ADP
admet-2403	268	22	nasal	nasal	PROPN
admet-2403	268	23	insufflation	insufflation	NOUN
admet-2403	268	24	.	.	PUNCT
admet-2403	269	1	international	international	ADJ
admet-2403	269	2	journal	journal	PROPN
admet-2403	269	3	of	of	ADP
admet-2403	269	4	pharmaceutics	pharmaceutic	NOUN
admet-2403	269	5	605	605	NUM
admet-2403	269	6	(	(	PUNCT
admet-2403	269	7	2021	2021	NUM
admet-2403	269	8	)	)	PUNCT
admet-2403	269	9	120827	120827	NUM
admet-2403	269	10	.	.	PUNCT
admet-2403	270	1	https://doi.org/10.1016/j.ijpharm.2021.120827	https://doi.org/10.1016/j.ijpharm.2021.120827	PROPN
admet-2403	271	1	[	[	X
admet-2403	271	2	26	26	NUM
admet-2403	271	3	]	]	X
admet-2403	271	4	g.	g.	PROPN
admet-2403	271	5	trapani	trapani	PROPN
admet-2403	271	6	,	,	PUNCT
admet-2403	271	7	a.	a.	PROPN
admet-2403	271	8	latrofa	latrofa	PROPN
admet-2403	271	9	,	,	PUNCT
admet-2403	271	10	m.	m.	NOUN
admet-2403	271	11	franco	franco	PROPN
admet-2403	271	12	,	,	PUNCT
admet-2403	271	13	a.	a.	NOUN
admet-2403	271	14	lopedota	lopedota	NOUN
admet-2403	271	15	,	,	PUNCT
admet-2403	271	16	e.	e.	PROPN
admet-2403	271	17	maciocco	maciocco	PROPN
admet-2403	271	18	,	,	PUNCT
admet-2403	271	19	g.	g.	PROPN
admet-2403	271	20	liso	liso	PROPN
admet-2403	271	21	.	.	PUNCT
admet-2403	272	1	effect	effect	NOUN
admet-2403	272	2	of	of	ADP
admet-2403	272	3	2	2	NUM
admet-2403	272	4	-	-	PUNCT
admet-2403	272	5	hydroxypropyl	hydroxypropyl	NOUN
admet-2403	272	6	-	-	PUNCT
admet-2403	272	7	βcyclodextrin	βcyclodextrin	NOUN
admet-2403	272	8	on	on	ADP
admet-2403	272	9	the	the	DET
admet-2403	272	10	aqueous	aqueous	ADJ
admet-2403	272	11	solubility	solubility	NOUN
admet-2403	272	12	of	of	ADP
admet-2403	272	13	the	the	DET
admet-2403	272	14	anaesthetic	anaesthetic	ADJ
admet-2403	272	15	agent	agent	NOUN
admet-2403	272	16	propofol	propofol	NOUN
admet-2403	272	17	(	(	PUNCT
admet-2403	272	18	2,6	2,6	NUM
admet-2403	272	19	-	-	NOUN
admet-2403	272	20	diisopropylphenol	diisopropylphenol	NOUN
admet-2403	272	21	)	)	PUNCT
admet-2403	272	22	.	.	PUNCT
admet-2403	273	1	international	international	ADJ
admet-2403	273	2	journal	journal	PROPN
admet-2403	273	3	of	of	ADP
admet-2403	273	4	pharmaceutics	pharmaceutic	NOUN
admet-2403	273	5	139	139	NUM
admet-2403	273	6	(	(	PUNCT
admet-2403	273	7	1996	1996	NUM
admet-2403	273	8	)	)	PUNCT
admet-2403	273	9	218	218	NUM
admet-2403	273	10	.	.	PUNCT
admet-2403	274	1	https://doi.org/10.1021/js970178s	https://doi.org/10.1021/js970178s	NOUN
admet-2403	274	2	[	[	X
admet-2403	275	1	27	27	NUM
admet-2403	275	2	]	]	X
admet-2403	275	3	m.k	m.k	PROPN
admet-2403	275	4	.	.	PUNCT
admet-2403	275	5	babu	babu	PROPN
admet-2403	275	6	,	,	PUNCT
admet-2403	275	7	t.n	t.n	PROPN
admet-2403	275	8	.	.	PROPN
admet-2403	275	9	godiwala	godiwala	NOUN
admet-2403	275	10	.	.	PUNCT
admet-2403	276	1	toward	toward	ADP
admet-2403	276	2	the	the	DET
admet-2403	276	3	development	development	NOUN
admet-2403	276	4	of	of	ADP
admet-2403	276	5	an	an	DET
admet-2403	276	6	injectable	injectable	ADJ
admet-2403	276	7	dosage	dosage	NOUN
admet-2403	276	8	form	form	NOUN
admet-2403	276	9	of	of	ADP
admet-2403	276	10	propofol	propofol	NOUN
admet-2403	276	11	:	:	PUNCT
admet-2403	276	12	preparation	preparation	NOUN
admet-2403	276	13	and	and	CCONJ
admet-2403	276	14	evaluation	evaluation	NOUN
admet-2403	276	15	of	of	ADP
admet-2403	276	16	propofol	propofol	ADJ
admet-2403	276	17	-	-	PUNCT
admet-2403	276	18	sulfobutyl	sulfobutyl	NOUN
admet-2403	276	19	ether	ether	NOUN
admet-2403	276	20	7	7	NUM
admet-2403	276	21	-	-	PUNCT
admet-2403	276	22	beta	beta	NOUN
admet-2403	276	23	-	-	PUNCT
admet-2403	276	24	cyclodextrin	cyclodextrin	NOUN
admet-2403	276	25	complex	complex	NOUN
admet-2403	276	26	.	.	PUNCT
admet-2403	277	1	pharmaceutical	pharmaceutical	NOUN
admet-2403	277	2	development	development	NOUN
admet-2403	277	3	and	and	CCONJ
admet-2403	277	4	technology	technology	NOUN
admet-2403	277	5	9	9	NUM
admet-2403	277	6	(	(	PUNCT
admet-2403	277	7	2004	2004	NUM
admet-2403	277	8	)	)	PUNCT
admet-2403	277	9	265	265	NUM
admet-2403	277	10	-	-	SYM
admet-2403	277	11	275	275	NUM
admet-2403	277	12	.	.	PUNCT
admet-2403	278	1	https://doi.org/10.1081/pdt200031428	https://doi.org/10.1081/pdt200031428	NOUN
admet-2403	278	2	[	[	X
admet-2403	278	3	28	28	NUM
admet-2403	278	4	]	]	X
admet-2403	278	5	g.	g.	PROPN
admet-2403	278	6	kali	kali	PROPN
admet-2403	278	7	,	,	PUNCT
admet-2403	278	8	s.	s.	PROPN
admet-2403	278	9	haddadzadegan	haddadzadegan	PROPN
admet-2403	278	10	,	,	PUNCT
admet-2403	278	11	a.	a.	PROPN
admet-2403	278	12	bernkop	bernkop	PROPN
admet-2403	278	13	-	-	PUNCT
admet-2403	278	14	schnürch	schnürch	NOUN
admet-2403	278	15	.	.	PUNCT
admet-2403	279	1	cyclodextrins	cyclodextrin	NOUN
admet-2403	279	2	and	and	CCONJ
admet-2403	279	3	derivatives	derivative	NOUN
admet-2403	279	4	in	in	ADP
admet-2403	279	5	drug	drug	NOUN
admet-2403	279	6	delivery	delivery	NOUN
admet-2403	279	7	:	:	PUNCT
admet-2403	279	8	new	new	ADJ
admet-2403	279	9	developments	development	NOUN
admet-2403	279	10	,	,	PUNCT
admet-2403	279	11	relevant	relevant	ADJ
admet-2403	279	12	clinical	clinical	ADJ
admet-2403	279	13	trials	trial	NOUN
admet-2403	279	14	,	,	PUNCT
admet-2403	279	15	and	and	CCONJ
admet-2403	279	16	advanced	advanced	ADJ
admet-2403	279	17	products	product	NOUN
admet-2403	279	18	.	.	PUNCT
admet-2403	280	1	carbohydrate	carbohydrate	NOUN
admet-2403	280	2	polymers	polymer	NOUN
admet-2403	280	3	324	324	NUM
admet-2403	280	4	(	(	PUNCT
admet-2403	280	5	2024	2024	NUM
admet-2403	280	6	)	)	PUNCT
admet-2403	280	7	121500	121500	NUM
admet-2403	280	8	.	.	PUNCT
admet-2403	281	1	https://doi.org/10.1016/j.carbpol.2023.121500	https://doi.org/10.1016/j.carbpol.2023.121500	PROPN
admet-2403	282	1	[	[	X
admet-2403	282	2	29	29	NUM
admet-2403	282	3	]	]	PUNCT
admet-2403	282	4	p.	p.	PROPN
admet-2403	282	5	yang	yang	PROPN
admet-2403	282	6	,	,	PUNCT
admet-2403	282	7	y.	y.	PROPN
admet-2403	282	8	li	li	PROPN
admet-2403	282	9	,	,	PUNCT
admet-2403	282	10	w.	w.	PROPN
admet-2403	282	11	li	li	PROPN
admet-2403	282	12	,	,	PUNCT
admet-2403	282	13	h.	h.	PROPN
admet-2403	282	14	zhang	zhang	PROPN
admet-2403	282	15	,	,	PUNCT
admet-2403	282	16	j.	j.	PROPN
admet-2403	282	17	gao	gao	PROPN
admet-2403	282	18	,	,	PUNCT
admet-2403	282	19	j.	j.	PROPN
admet-2403	282	20	sun	sun	PROPN
admet-2403	282	21	,	,	PUNCT
admet-2403	282	22	x.	x.	PROPN
admet-2403	282	23	yin	yin	PROPN
admet-2403	282	24	,	,	PUNCT
admet-2403	282	25	a.	a.	PROPN
admet-2403	282	26	zheng	zheng	PROPN
admet-2403	282	27	.	.	PUNCT
admet-2403	283	1	preparation	preparation	NOUN
admet-2403	283	2	and	and	CCONJ
admet-2403	283	3	evaluation	evaluation	NOUN
admet-2403	283	4	of	of	ADP
admet-2403	283	5	carfentanil	carfentanil	PROPN
admet-2403	283	6	nasal	nasal	PROPN
admet-2403	283	7	spray	spray	NOUN
admet-2403	283	8	employing	employ	VERB
admet-2403	283	9	cyclodextrin	cyclodextrin	NOUN
admet-2403	283	10	inclusion	inclusion	NOUN
admet-2403	283	11	technology	technology	NOUN
admet-2403	283	12	.	.	PUNCT
admet-2403	284	1	drug	drug	NOUN
admet-2403	284	2	development	development	NOUN
admet-2403	284	3	and	and	CCONJ
admet-2403	284	4	industrial	industrial	ADJ
admet-2403	284	5	pharmacy	pharmacy	NOUN
admet-2403	284	6	44	44	NUM
admet-2403	284	7	(	(	PUNCT
admet-2403	284	8	2018	2018	NUM
admet-2403	284	9	)	)	PUNCT
admet-2403	284	10	953	953	NUM
admet-2403	284	11	-	-	SYM
admet-2403	284	12	960	960	NUM
admet-2403	284	13	.	.	PUNCT
admet-2403	284	14	https://doi.org/10.1080/03639045.2018.1425426	https://doi.org/10.1080/03639045.2018.1425426	X
admet-2403	285	1	[	[	X
admet-2403	285	2	30	30	NUM
admet-2403	285	3	]	]	X
admet-2403	285	4	c.	c.	NOUN
admet-2403	285	5	muankaew	muankaew	VERB
admet-2403	285	6	,	,	PUNCT
admet-2403	285	7	t.	t.	PROPN
admet-2403	285	8	loftsson	loftsson	NOUN
admet-2403	285	9	.	.	PUNCT
admet-2403	286	1	cyclodextrin	cyclodextrin	NOUN
admet-2403	286	2	-	-	PUNCT
admet-2403	286	3	based	base	VERB
admet-2403	286	4	formulations	formulation	NOUN
admet-2403	286	5	:	:	PUNCT
admet-2403	286	6	a	a	DET
admet-2403	286	7	non	non	ADJ
admet-2403	286	8	-	-	ADJ
admet-2403	286	9	invasive	invasive	ADJ
admet-2403	286	10	platform	platform	NOUN
admet-2403	286	11	for	for	ADP
admet-2403	286	12	targeted	target	VERB
admet-2403	286	13	drug	drug	NOUN
admet-2403	286	14	delivery	delivery	NOUN
admet-2403	286	15	.	.	PUNCT
admet-2403	287	1	basic	basic	ADJ
admet-2403	287	2	&	&	CCONJ
admet-2403	287	3	clinical	clinical	ADJ
admet-2403	287	4	pharmacology	pharmacology	NOUN
admet-2403	287	5	&	&	CCONJ
admet-2403	287	6	toxicology	toxicology	NOUN
admet-2403	287	7	122	122	NUM
admet-2403	287	8	(	(	PUNCT
admet-2403	287	9	2018	2018	NUM
admet-2403	287	10	)	)	PUNCT
admet-2403	287	11	46	46	NUM
admet-2403	287	12	-	-	SYM
admet-2403	287	13	55	55	NUM
admet-2403	287	14	.	.	PUNCT
admet-2403	288	1	https://doi.org/10.1111/bcpt.12917	https://doi.org/10.1111/bcpt.12917	ADJ
admet-2403	289	1	[	[	X
admet-2403	289	2	31	31	NUM
admet-2403	289	3	]	]	PUNCT
admet-2403	289	4	g.	g.	PROPN
admet-2403	289	5	rassu	rassu	PROPN
admet-2403	289	6	,	,	PUNCT
admet-2403	289	7	m.	m.	NOUN
admet-2403	289	8	sorrenti	sorrenti	PROPN
admet-2403	289	9	,	,	PUNCT
admet-2403	289	10	l.	l.	PROPN
admet-2403	289	11	catenacci	catenacci	PROPN
admet-2403	289	12	,	,	PUNCT
admet-2403	289	13	b.	b.	PROPN
admet-2403	289	14	pavan	pavan	PROPN
admet-2403	289	15	,	,	PUNCT
admet-2403	289	16	l.	l.	PROPN
admet-2403	289	17	ferraro	ferraro	PROPN
admet-2403	289	18	,	,	PUNCT
admet-2403	289	19	e.	e.	PROPN
admet-2403	289	20	gavini	gavini	PROPN
admet-2403	289	21	,	,	PUNCT
admet-2403	289	22	m.c	m.c	PROPN
admet-2403	289	23	.	.	PROPN
admet-2403	289	24	bonferoni	bonferoni	NOUN
admet-2403	289	25	,	,	PUNCT
admet-2403	289	26	p.	p.	NOUN
admet-2403	289	27	giunchedi	giunchedi	PROPN
admet-2403	289	28	,	,	PUNCT
admet-2403	289	29	a.	a.	NOUN
admet-2403	289	30	dalpiaz	dalpiaz	PROPN
admet-2403	289	31	.	.	PUNCT
admet-2403	290	1	versatile	versatile	ADJ
admet-2403	290	2	nasal	nasal	ADJ
admet-2403	290	3	application	application	NOUN
admet-2403	290	4	of	of	ADP
admet-2403	290	5	cyclodextrins	cyclodextrin	NOUN
admet-2403	290	6	:	:	PUNCT
admet-2403	290	7	excipients	excipient	NOUN
admet-2403	290	8	and/or	and/or	CCONJ
admet-2403	290	9	actives	active	NOUN
admet-2403	290	10	.	.	PUNCT
admet-2403	291	1	pharmaceutics	pharmaceutic	NOUN
admet-2403	291	2	13	13	NUM
admet-2403	291	3	(	(	PUNCT
admet-2403	291	4	2021	2021	NUM
admet-2403	291	5	)	)	PUNCT
admet-2403	291	6	1180	1180	NUM
admet-2403	291	7	.	.	PUNCT
admet-2403	292	1	https://doi.org/10.3390/pharmaceutics13081180	https://doi.org/10.3390/pharmaceutics13081180	NOUN
admet-2403	292	2	[	[	X
admet-2403	292	3	32	32	NUM
admet-2403	292	4	]	]	X
admet-2403	292	5	j.y	j.y	PROPN
admet-2403	292	6	.	.	PROPN
admet-2403	292	7	sim	sim	PROPN
admet-2403	292	8	,	,	PUNCT
admet-2403	292	9	s.h	s.h	PROPN
admet-2403	292	10	.	.	PROPN
admet-2403	292	11	lee	lee	PROPN
admet-2403	292	12	,	,	PUNCT
admet-2403	292	13	d.y	d.y	PROPN
admet-2403	292	14	.	.	PROPN
admet-2403	292	15	park	park	PROPN
admet-2403	292	16	,	,	PUNCT
admet-2403	292	17	j.a	j.a	PROPN
admet-2403	292	18	.	.	PROPN
admet-2403	292	19	jung	jung	PROPN
admet-2403	292	20	,	,	PUNCT
admet-2403	292	21	k.h	k.h	PROPN
admet-2403	292	22	.	.	PROPN
admet-2403	293	1	ki	ki	PROPN
admet-2403	293	2	,	,	PUNCT
admet-2403	293	3	d.h	d.h	PROPN
admet-2403	293	4	.	.	PROPN
admet-2403	293	5	lee	lee	PROPN
admet-2403	293	6	,	,	PUNCT
admet-2403	293	7	g.j	g.j	PROPN
admet-2403	293	8	.	.	PROPN
admet-2403	293	9	noh	noh	PROPN
admet-2403	293	10	.	.	PUNCT
admet-2403	293	11	pain	pain	NOUN
admet-2403	293	12	on	on	ADP
admet-2403	293	13	injection	injection	NOUN
admet-2403	293	14	with	with	ADP
admet-2403	293	15	microemulsion	microemulsion	NOUN
admet-2403	293	16	propofol	propofol	NOUN
admet-2403	293	17	.	.	PUNCT
admet-2403	294	1	british	british	ADJ
admet-2403	294	2	journal	journal	PROPN
admet-2403	294	3	of	of	ADP
admet-2403	294	4	clinical	clinical	ADJ
admet-2403	294	5	pharmacology	pharmacology	NOUN
admet-2403	294	6	67	67	NUM
admet-2403	294	7	(	(	PUNCT
admet-2403	294	8	2009	2009	NUM
admet-2403	294	9	)	)	PUNCT
admet-2403	294	10	316	316	NUM
admet-2403	294	11	-	-	SYM
admet-2403	294	12	325	325	NUM
admet-2403	294	13	.	.	PUNCT
admet-2403	295	1	https://doi.org/10.1111/j.13652125.2008.03358.x	https://doi.org/10.1111/j.13652125.2008.03358.x	X
admet-2403	296	1	[	[	X
admet-2403	296	2	33	33	NUM
admet-2403	296	3	]	]	PUNCT
admet-2403	296	4	m.	m.	NOUN
admet-2403	296	5	yamakage	yamakage	PROPN
admet-2403	296	6	,	,	PUNCT
admet-2403	296	7	s.	s.	PROPN
admet-2403	296	8	iwasaki	iwasaki	PROPN
admet-2403	296	9	,	,	PUNCT
admet-2403	296	10	j.i	j.i	PROPN
admet-2403	296	11	.	.	PROPN
admet-2403	296	12	satoh	satoh	PROPN
admet-2403	296	13	,	,	PUNCT
admet-2403	296	14	a.	a.	NOUN
admet-2403	296	15	namiki	namiki	PROPN
admet-2403	296	16	.	.	PUNCT
admet-2403	297	1	changes	change	NOUN
admet-2403	297	2	in	in	ADP
admet-2403	297	3	concentrations	concentration	NOUN
admet-2403	297	4	of	of	ADP
admet-2403	297	5	free	free	ADJ
admet-2403	297	6	propofol	propofol	NOUN
admet-2403	297	7	by	by	ADP
admet-2403	297	8	modification	modification	NOUN
admet-2403	297	9	of	of	ADP
admet-2403	297	10	the	the	DET
admet-2403	297	11	solution	solution	NOUN
admet-2403	297	12	.	.	PUNCT
admet-2403	298	1	anesthesia	anesthesia	PROPN
admet-2403	298	2	&	&	CCONJ
admet-2403	298	3	analgesia	analgesia	PROPN
admet-2403	298	4	101	101	NUM
admet-2403	298	5	(	(	PUNCT
admet-2403	298	6	2005	2005	NUM
admet-2403	298	7	)	)	PUNCT
admet-2403	298	8	385	385	NUM
admet-2403	298	9	-	-	SYM
admet-2403	298	10	388	388	NUM
admet-2403	298	11	.	.	PUNCT
admet-2403	298	12	https://doi.org/10.1213/01.ane.0000154191.86608.ac	https://doi.org/10.1213/01.ane.0000154191.86608.ac	VERB
admet-2403	299	1	[	[	X
admet-2403	299	2	34	34	NUM
admet-2403	299	3	]	]	X
admet-2403	299	4	r.	r.	NOUN
admet-2403	299	5	damitz	damitz	PROPN
admet-2403	299	6	,	,	PUNCT
admet-2403	299	7	a.	a.	NOUN
admet-2403	299	8	chauhan	chauhan	PROPN
admet-2403	299	9	,	,	PUNCT
admet-2403	299	10	n.	n.	PROPN
admet-2403	299	11	gravenstein	gravenstein	PROPN
admet-2403	299	12	.	.	PUNCT
admet-2403	300	1	propofol	propofol	ADJ
admet-2403	300	2	emulsion	emulsion	NOUN
admet-2403	300	3	-	-	PUNCT
admet-2403	300	4	free	free	ADJ
admet-2403	300	5	drug	drug	NOUN
admet-2403	300	6	concentration	concentration	NOUN
admet-2403	300	7	is	be	AUX
admet-2403	300	8	similar	similar	ADJ
admet-2403	300	9	between	between	ADP
admet-2403	300	10	batches	batch	NOUN
admet-2403	300	11	and	and	CCONJ
admet-2403	300	12	stable	stable	ADJ
admet-2403	300	13	over	over	ADP
admet-2403	300	14	time	time	NOUN
admet-2403	300	15	.	.	PUNCT
admet-2403	301	1	romanian	romanian	ADJ
admet-2403	301	2	journal	journal	PROPN
admet-2403	301	3	of	of	ADP
admet-2403	301	4	anaesthesia	anaesthesia	NOUN
admet-2403	301	5	and	and	CCONJ
admet-2403	301	6	intensive	intensive	ADJ
admet-2403	301	7	care	care	NOUN
admet-2403	301	8	23	23	NUM
admet-2403	301	9	(	(	PUNCT
admet-2403	301	10	2016	2016	NUM
admet-2403	301	11	)	)	PUNCT
admet-2403	301	12	7	7	NUM
admet-2403	301	13	-	-	SYM
admet-2403	301	14	11	11	NUM
admet-2403	301	15	.	.	PUNCT
admet-2403	302	1	https://doi.org/10.21454/rjaic.7518.231.emf	https://doi.org/10.21454/rjaic.7518.231.emf	PROPN
admet-2403	302	2	[	[	X
admet-2403	302	3	35	35	NUM
admet-2403	302	4	]	]	X
admet-2403	302	5	r.	r.	PROPN
admet-2403	302	6	mitra	mitra	PROPN
admet-2403	302	7	,	,	PUNCT
admet-2403	302	8	i.	i.	PROPN
admet-2403	302	9	pezron	pezron	PROPN
admet-2403	302	10	,	,	PUNCT
admet-2403	302	11	w.a	w.a	PROPN
admet-2403	302	12	.	.	PROPN
admet-2403	302	13	chu	chu	PROPN
admet-2403	302	14	,	,	PUNCT
admet-2403	302	15	a.k	a.k	PROPN
admet-2403	302	16	.	.	PROPN
admet-2403	302	17	mitra	mitra	PROPN
admet-2403	302	18	.	.	PROPN
admet-2403	302	19	lipid	lipid	PROPN
admet-2403	302	20	emulsions	emulsion	NOUN
admet-2403	302	21	as	as	ADP
admet-2403	302	22	vehicles	vehicle	NOUN
admet-2403	302	23	for	for	ADP
admet-2403	302	24	enhanced	enhanced	ADJ
admet-2403	302	25	nasal	nasal	ADJ
admet-2403	302	26	delivery	delivery	NOUN
admet-2403	302	27	of	of	ADP
admet-2403	302	28	insulin	insulin	NOUN
admet-2403	302	29	.	.	PUNCT
admet-2403	303	1	international	international	ADJ
admet-2403	303	2	journal	journal	PROPN
admet-2403	303	3	of	of	ADP
admet-2403	303	4	pharmaceutics	pharmaceutic	NOUN
admet-2403	303	5	205	205	NUM
admet-2403	303	6	(	(	PUNCT
admet-2403	303	7	2000	2000	NUM
admet-2403	303	8	)	)	PUNCT
admet-2403	303	9	127	127	NUM
admet-2403	303	10	-	-	SYM
admet-2403	303	11	134	134	NUM
admet-2403	303	12	.	.	PUNCT
admet-2403	304	1	https://doi.org/10.1016/s03785173(00)00506-8	https://doi.org/10.1016/s03785173(00)00506-8	NOUN
admet-2403	305	1	[	[	X
admet-2403	305	2	36	36	NUM
admet-2403	305	3	]	]	PUNCT
admet-2403	305	4	t.	t.	PROPN
admet-2403	305	5	loftsson	loftsson	PROPN
admet-2403	305	6	,	,	PUNCT
admet-2403	305	7	h.h	h.h	PROPN
admet-2403	305	8	.	.	PROPN
admet-2403	305	9	sigurdsson	sigurdsson	PROPN
admet-2403	305	10	,	,	PUNCT
admet-2403	305	11	p.	p.	PROPN
admet-2403	305	12	jansook	jansook	PROPN
admet-2403	305	13	.	.	PUNCT
admet-2403	306	1	anomalous	anomalous	ADJ
admet-2403	306	2	properties	property	NOUN
admet-2403	306	3	of	of	ADP
admet-2403	306	4	cyclodextrins	cyclodextrin	NOUN
admet-2403	306	5	and	and	CCONJ
admet-2403	306	6	their	their	PRON
admet-2403	306	7	complexes	complex	NOUN
admet-2403	306	8	in	in	ADP
admet-2403	306	9	aqueous	aqueous	ADJ
admet-2403	306	10	solutions	solution	NOUN
admet-2403	306	11	.	.	PUNCT
admet-2403	307	1	materials	material	NOUN
admet-2403	307	2	16	16	NUM
admet-2403	307	3	(	(	PUNCT
admet-2403	307	4	2023	2023	NUM
admet-2403	307	5	)	)	PUNCT
admet-2403	307	6	2223	2223	NUM
admet-2403	307	7	.	.	PUNCT
admet-2403	308	1	https://doi.org/10.3390/ma16062223	https://doi.org/10.3390/ma16062223	NOUN
admet-2403	308	2	https://doi.org/10.5599/admet.2403	https://doi.org/10.5599/admet.2403	NOUN
admet-2403	308	3	https://doi.org/10.1016/j.ejps.2008.12.015	https://doi.org/10.1016/j.ejps.2008.12.015	X
admet-2403	308	4	https://doi.org/10.1016/j.ijpharm.2012.09.049	https://doi.org/10.1016/j.ijpharm.2012.09.049	PROPN
admet-2403	308	5	https://doi.org/10.1016/j.ijpharm.2016.07.002	https://doi.org/10.1016/j.ijpharm.2016.07.002	NOUN
admet-2403	308	6	https://doi.org/10.1016/j.ijpharm.2021.120827	https://doi.org/10.1016/j.ijpharm.2021.120827	PROPN
admet-2403	308	7	https://doi.org/10.1021/js970178s	https://doi.org/10.1021/js970178s	NOUN
admet-2403	308	8	https://doi.org/10.1081/pdt-200031428	https://doi.org/10.1081/pdt-200031428	ADP
admet-2403	308	9	https://doi.org/10.1081/pdt-200031428	https://doi.org/10.1081/pdt-200031428	PROPN
admet-2403	308	10	https://doi.org/10.1016/j.carbpol.2023.121500	https://doi.org/10.1016/j.carbpol.2023.121500	NOUN
admet-2403	308	11	https://doi.org/10.1080/03639045.2018.1425426	https://doi.org/10.1080/03639045.2018.1425426	PROPN
admet-2403	308	12	https://doi.org/10.1111/bcpt.12917	https://doi.org/10.1111/bcpt.12917	ADJ
admet-2403	308	13	https://doi.org/10.3390/pharmaceutics13081180	https://doi.org/10.3390/pharmaceutics13081180	PROPN
admet-2403	308	14	https://doi.org/10.1111/j.1365-2125.2008.03358.x	https://doi.org/10.1111/j.1365-2125.2008.03358.x	PROPN
admet-2403	308	15	https://doi.org/10.1111/j.1365-2125.2008.03358.x	https://doi.org/10.1111/j.1365-2125.2008.03358.x	PROPN
admet-2403	308	16	https://doi.org/10.1213/01.ane.0000154191.86608.ac	https://doi.org/10.1213/01.ane.0000154191.86608.ac	VERB
admet-2403	308	17	https://doi.org/10.21454/rjaic.7518.231.emf	https://doi.org/10.21454/rjaic.7518.231.emf	PROPN
admet-2403	308	18	https://doi.org/10.1016/s0378-5173(00)00506-8	https://doi.org/10.1016/s0378-5173(00)00506-8	PROPN
admet-2403	308	19	https://doi.org/10.1016/s0378-5173(00)00506-8	https://doi.org/10.1016/s0378-5173(00)00506-8	PROPN
admet-2403	308	20	https://doi.org/10.3390/ma16062223	https://doi.org/10.3390/ma16062223	PROPN
admet-2403	308	21	m.	m.	PROPN
admet-2403	308	22	d.	d.	PROPN
admet-2403	308	23	spampinato	spampinato	PROPN
admet-2403	308	24	et	et	PROPN
admet-2403	308	25	al	al	PROPN
admet-2403	308	26	.	.	PROPN
admet-2403	308	27	admet	admet	PROPN
admet-2403	308	28	&	&	CCONJ
admet-2403	308	29	dmpk	dmpk	PROPN
admet-2403	308	30	12(5	12(5	NUM
admet-2403	308	31	)	)	PUNCT
admet-2403	308	32	(	(	PUNCT
admet-2403	308	33	2024	2024	NUM
admet-2403	308	34	)	)	PUNCT
admet-2403	308	35	759	759	NUM
admet-2403	308	36	-	-	SYM
admet-2403	308	37	768	768	NUM
admet-2403	308	38	768	768	NUM
admet-2403	309	1	[	[	SYM
admet-2403	309	2	37	37	NUM
admet-2403	309	3	]	]	PUNCT
admet-2403	309	4	p.	p.	NOUN
admet-2403	309	5	papakyriakopoulou	papakyriakopoulou	PROPN
admet-2403	309	6	,	,	PUNCT
admet-2403	309	7	k.	k.	PROPN
admet-2403	309	8	manta	manta	PROPN
admet-2403	309	9	,	,	PUNCT
admet-2403	309	10	c.	c.	PROPN
admet-2403	309	11	kostantini	kostantini	PROPN
admet-2403	309	12	,	,	PUNCT
admet-2403	309	13	s.	s.	PROPN
admet-2403	309	14	kikionis	kikionis	PROPN
admet-2403	309	15	,	,	PUNCT
admet-2403	309	16	s.	s.	PROPN
admet-2403	309	17	banella	banella	PROPN
admet-2403	309	18	,	,	PUNCT
admet-2403	309	19	e.	e.	PROPN
admet-2403	309	20	ioannou	ioannou	PROPN
admet-2403	309	21	,	,	PUNCT
admet-2403	309	22	e.	e.	PROPN
admet-2403	309	23	christodoulou	christodoulou	PROPN
admet-2403	309	24	,	,	PUNCT
admet-2403	309	25	d.m	d.m	PROPN
admet-2403	309	26	.	.	PROPN
admet-2403	309	27	rekkas	rekkas	PROPN
admet-2403	309	28	,	,	PUNCT
admet-2403	309	29	p.	p.	PROPN
admet-2403	309	30	dallas	dallas	PROPN
admet-2403	309	31	,	,	PUNCT
admet-2403	309	32	m.	m.	NOUN
admet-2403	309	33	vertzoni	vertzoni	PROPN
admet-2403	309	34	,	,	PUNCT
admet-2403	309	35	g.	g.	PROPN
admet-2403	309	36	valsami	valsami	PROPN
admet-2403	309	37	,	,	PUNCT
admet-2403	309	38	g.	g.	PROPN
admet-2403	309	39	colombo	colombo	PROPN
admet-2403	309	40	.	.	PUNCT
admet-2403	310	1	nasal	nasal	PROPN
admet-2403	310	2	powders	powder	NOUN
admet-2403	310	3	of	of	ADP
admet-2403	310	4	quercetin	quercetin	NOUN
admet-2403	310	5	-	-	PUNCT
admet-2403	310	6	βcyclodextrin	βcyclodextrin	NOUN
admet-2403	310	7	derivatives	derivative	NOUN
admet-2403	310	8	complexes	complex	NOUN
admet-2403	310	9	with	with	ADP
admet-2403	310	10	mannitol	mannitol	NOUN
admet-2403	310	11	/	/	SYM
admet-2403	310	12	lecithin	lecithin	NOUN
admet-2403	310	13	microparticles	microparticle	NOUN
admet-2403	310	14	for	for	ADP
admet-2403	310	15	nose	nose	NOUN
admet-2403	310	16	-	-	PUNCT
admet-2403	310	17	to	to	ADP
admet-2403	310	18	-	-	PUNCT
admet-2403	310	19	brain	brain	NOUN
admet-2403	310	20	delivery	delivery	NOUN
admet-2403	310	21	:	:	PUNCT
admet-2403	310	22	in	in	ADP
admet-2403	310	23	vitro	vitro	X
admet-2403	310	24	and	and	CCONJ
admet-2403	310	25	ex	ex	ADJ
admet-2403	310	26	vivo	vivo	ADJ
admet-2403	310	27	evaluation	evaluation	NOUN
admet-2403	310	28	.	.	PUNCT
admet-2403	311	1	international	international	ADJ
admet-2403	311	2	journal	journal	PROPN
admet-2403	311	3	of	of	ADP
admet-2403	311	4	pharmaceutics	pharmaceutic	NOUN
admet-2403	311	5	607	607	NUM
admet-2403	311	6	(	(	PUNCT
admet-2403	311	7	2021	2021	NUM
admet-2403	311	8	)	)	PUNCT
admet-2403	311	9	121016	121016	NUM
admet-2403	311	10	.	.	PUNCT
admet-2403	312	1	https://doi.org/10.1016/j.ijpharm.2021.121016	https://doi.org/10.1016/j.ijpharm.2021.121016	PROPN
admet-2403	312	2	[	[	X
admet-2403	312	3	38	38	NUM
admet-2403	312	4	]	]	X
admet-2403	312	5	v.	v.	PROPN
admet-2403	312	6	raje	raje	PROPN
admet-2403	312	7	,	,	PUNCT
admet-2403	312	8	s.	s.	PROPN
admet-2403	312	9	palekar	palekar	PROPN
admet-2403	312	10	,	,	PUNCT
admet-2403	312	11	s.	s.	PROPN
admet-2403	312	12	banella	banella	PROPN
admet-2403	312	13	,	,	PUNCT
admet-2403	312	14	k.	k.	PROPN
admet-2403	312	15	patel	patel	PROPN
admet-2403	312	16	.	.	PUNCT
admet-2403	313	1	tunable	tunable	ADJ
admet-2403	313	2	drug	drug	NOUN
admet-2403	313	3	release	release	NOUN
admet-2403	313	4	from	from	ADP
admet-2403	313	5	fused	fuse	VERB
admet-2403	313	6	deposition	deposition	NOUN
admet-2403	313	7	modelling	modelling	NOUN
admet-2403	313	8	(	(	PUNCT
admet-2403	313	9	fdm	fdm	NOUN
admet-2403	313	10	)	)	PUNCT
admet-2403	313	11	3d	3d	NOUN
admet-2403	313	12	-	-	PUNCT
admet-2403	313	13	printed	print	VERB
admet-2403	313	14	tablets	tablet	NOUN
admet-2403	313	15	fabricated	fabricate	VERB
admet-2403	313	16	using	use	VERB
admet-2403	313	17	a	a	DET
admet-2403	313	18	novel	novel	ADJ
admet-2403	313	19	extrudable	extrudable	ADJ
admet-2403	313	20	polymer	polymer	NOUN
admet-2403	313	21	.	.	PUNCT
admet-2403	314	1	pharmaceutics	pharmaceutic	NOUN
admet-2403	314	2	14	14	NUM
admet-2403	314	3	(	(	PUNCT
admet-2403	314	4	2022	2022	NUM
admet-2403	314	5	)	)	PUNCT
admet-2403	314	6	2192	2192	NUM
admet-2403	314	7	.	.	PUNCT
admet-2403	315	1	https://doi.org/10.3390/pharmaceutics14102192	https://doi.org/10.3390/pharmaceutics14102192	NOUN
admet-2403	315	2	[	[	X
admet-2403	315	3	39	39	NUM
admet-2403	315	4	]	]	PUNCT
admet-2403	315	5	m.	m.	NOUN
admet-2403	315	6	pozzoli	pozzoli	PROPN
admet-2403	315	7	,	,	PUNCT
admet-2403	315	8	d.	d.	PROPN
admet-2403	315	9	traini	traini	PROPN
admet-2403	315	10	,	,	PUNCT
admet-2403	315	11	p.m.	p.m.	PROPN
admet-2403	315	12	young	young	ADJ
admet-2403	315	13	,	,	PUNCT
admet-2403	315	14	m.b	m.b	PROPN
admet-2403	315	15	.	.	PROPN
admet-2403	315	16	sukkar	sukkar	PROPN
admet-2403	315	17	,	,	PUNCT
admet-2403	315	18	f.	f.	PROPN
admet-2403	315	19	sonvico	sonvico	PROPN
admet-2403	315	20	.	.	PUNCT
admet-2403	316	1	development	development	NOUN
admet-2403	316	2	of	of	ADP
admet-2403	316	3	a	a	DET
admet-2403	316	4	soluplus	soluplus	ADJ
admet-2403	316	5	budesonide	budesonide	NOUN
admet-2403	316	6	freeze	freeze	NOUN
admet-2403	316	7	-	-	PUNCT
admet-2403	316	8	dried	dry	VERB
admet-2403	316	9	powder	powder	NOUN
admet-2403	316	10	for	for	ADP
admet-2403	316	11	nasal	nasal	ADJ
admet-2403	316	12	drug	drug	NOUN
admet-2403	316	13	delivery	delivery	NOUN
admet-2403	316	14	.	.	PUNCT
admet-2403	317	1	drug	drug	NOUN
admet-2403	317	2	development	development	NOUN
admet-2403	317	3	and	and	CCONJ
admet-2403	317	4	industrial	industrial	ADJ
admet-2403	317	5	pharmacy	pharmacy	NOUN
admet-2403	317	6	43	43	NUM
admet-2403	317	7	(	(	PUNCT
admet-2403	317	8	2017	2017	NUM
admet-2403	317	9	)	)	PUNCT
admet-2403	317	10	1510	1510	NUM
admet-2403	317	11	-	-	SYM
admet-2403	317	12	1518	1518	NUM
admet-2403	317	13	.	.	PUNCT
admet-2403	318	1	https://doi.org/10.1080/03639045.2017.1321659	https://doi.org/10.1080/03639045.2017.1321659	X
admet-2403	319	1	©	©	NOUN
admet-2403	319	2	2024	2024	NUM
admet-2403	319	3	by	by	ADP
admet-2403	319	4	the	the	DET
admet-2403	319	5	authors	author	NOUN
admet-2403	319	6	;	;	PUNCT
admet-2403	319	7	licensee	licensee	PROPN
admet-2403	319	8	iapc	iapc	PROPN
admet-2403	319	9	,	,	PUNCT
admet-2403	319	10	zagreb	zagreb	PROPN
admet-2403	319	11	,	,	PUNCT
admet-2403	319	12	croatia	croatia	PROPN
admet-2403	319	13	.	.	PUNCT
admet-2403	320	1	this	this	DET
admet-2403	320	2	article	article	NOUN
admet-2403	320	3	is	be	AUX
admet-2403	320	4	an	an	DET
admet-2403	320	5	open	open	ADJ
admet-2403	320	6	-	-	PUNCT
admet-2403	320	7	access	access	NOUN
admet-2403	320	8	article	article	NOUN
admet-2403	320	9	distributed	distribute	VERB
admet-2403	320	10	under	under	ADP
admet-2403	320	11	the	the	DET
admet-2403	320	12	terms	term	NOUN
admet-2403	320	13	and	and	CCONJ
admet-2403	320	14	conditions	condition	NOUN
admet-2403	320	15	of	of	ADP
admet-2403	320	16	the	the	DET
admet-2403	320	17	creative	creative	ADJ
admet-2403	320	18	commons	common	NOUN
admet-2403	320	19	attribution	attribution	NOUN
admet-2403	320	20	license	license	NOUN
admet-2403	320	21	(	(	PUNCT
admet-2403	320	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2403	320	23	)	)	PUNCT
admet-2403	320	24	https://doi.org/10.1016/j.ijpharm.2021.121016	https://doi.org/10.1016/j.ijpharm.2021.121016	PROPN
admet-2403	320	25	https://doi.org/10.3390/pharmaceutics14102192	https://doi.org/10.3390/pharmaceutics14102192	X
admet-2403	320	26	https://doi.org/10.1080/03639045.2017.1321659	https://doi.org/10.1080/03639045.2017.1321659	PUNCT
admet-2403	321	1	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN