id	sid	tid	token	lemma	pos
admet-2414	1	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	1	2	/	/	SYM
admet-2414	1	3	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	1	4	of	of	ADP
admet-2414	1	5	glucocorticoids	glucocorticoid	NOUN
admet-2414	1	6	:	:	PUNCT
admet-2414	1	7	modeling	model	VERB
admet-2414	1	8	the	the	DET
admet-2414	1	9	glucocorticoid	glucocorticoid	ADJ
admet-2414	1	10	receptor	receptor	NOUN
admet-2414	1	11	dynamics	dynamic	NOUN
admet-2414	1	12	and	and	CCONJ
admet-2414	1	13	dose	dose	NOUN
admet-2414	1	14	/	/	SYM
admet-2414	1	15	response	response	NOUN
admet-2414	1	16	of	of	ADP
admet-2414	1	17	commonly	commonly	ADV
admet-2414	1	18	prescribed	prescribe	VERB
admet-2414	1	19	glucocorticoids	glucocorticoid	NOUN
admet-2414	1	20	doi	doi	NOUN
admet-2414	1	21	:	:	PUNCT
admet-2414	1	22	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	1	23	971	971	NUM
admet-2414	1	24	admet	admet	PROPN
admet-2414	1	25	&	&	CCONJ
admet-2414	1	26	dmpk	dmpk	PROPN
admet-2414	1	27	12(6	12(6	NUM
admet-2414	1	28	)	)	PUNCT
admet-2414	1	29	(	(	PUNCT
admet-2414	1	30	2024	2024	NUM
admet-2414	1	31	)	)	PUNCT
admet-2414	1	32	971	971	NUM
admet-2414	1	33	-	-	SYM
admet-2414	1	34	989	989	NUM
admet-2414	1	35	;	;	PUNCT
admet-2414	1	36	doi	doi	NOUN
admet-2414	1	37	:	:	PUNCT
admet-2414	1	38	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	1	39	open	open	ADJ
admet-2414	1	40	access	access	NOUN
admet-2414	1	41	:	:	PUNCT
admet-2414	1	42	issn	issn	PROPN
admet-2414	1	43	:	:	PUNCT
admet-2414	1	44	1848	1848	NUM
admet-2414	1	45	-	-	SYM
admet-2414	1	46	7718	7718	NUM
admet-2414	1	47	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2414	1	48	original	original	ADJ
admet-2414	1	49	scientific	scientific	ADJ
admet-2414	1	50	paper	paper	NOUN
admet-2414	1	51	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	1	52	/	/	SYM
admet-2414	1	53	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	1	54	of	of	ADP
admet-2414	1	55	glucocorticoids	glucocorticoid	NOUN
admet-2414	1	56	:	:	PUNCT
admet-2414	1	57	modeling	model	VERB
admet-2414	1	58	the	the	DET
admet-2414	1	59	glucocorticoid	glucocorticoid	ADJ
admet-2414	1	60	receptor	receptor	NOUN
admet-2414	1	61	dynamics	dynamic	NOUN
admet-2414	1	62	and	and	CCONJ
admet-2414	1	63	dose	dose	NOUN
admet-2414	1	64	/	/	SYM
admet-2414	1	65	response	response	NOUN
admet-2414	1	66	of	of	ADP
admet-2414	1	67	commonly	commonly	ADV
admet-2414	1	68	prescribed	prescribe	VERB
admet-2414	1	69	glucocorticoids	glucocorticoid	NOUN
admet-2414	1	70	david	david	PROPN
admet-2414	1	71	g.	g.	PROPN
admet-2414	1	72	levitt	levitt	PROPN
admet-2414	1	73	department	department	PROPN
admet-2414	1	74	of	of	ADP
admet-2414	1	75	integrative	integrative	ADJ
admet-2414	1	76	biology	biology	NOUN
admet-2414	1	77	and	and	CCONJ
admet-2414	1	78	physiology	physiology	NOUN
admet-2414	1	79	,	,	PUNCT
admet-2414	1	80	university	university	NOUN
admet-2414	1	81	of	of	ADP
admet-2414	1	82	minnesota	minnesota	PROPN
admet-2414	1	83	,	,	PUNCT
admet-2414	1	84	minneapolis	minneapolis	PROPN
admet-2414	1	85	,	,	PUNCT
admet-2414	1	86	mn	mn	PROPN
admet-2414	1	87	55455	55455	NUM
admet-2414	1	88	,	,	PUNCT
admet-2414	1	89	usa	usa	PROPN
admet-2414	1	90	corresponding	corresponding	PROPN
admet-2414	1	91	authors	author	NOUN
admet-2414	1	92	:	:	PUNCT
admet-2414	1	93	e	e	X
admet-2414	1	94	-	-	NOUN
admet-2414	1	95	mail	mail	NOUN
admet-2414	1	96	:	:	PUNCT
admet-2414	1	97	levit001@umn.edu	levit001@umn.edu	PROPN
admet-2414	1	98	received	receive	VERB
admet-2414	1	99	:	:	PUNCT
admet-2414	1	100	july	july	PROPN
admet-2414	1	101	5	5	NUM
admet-2414	1	102	,	,	PUNCT
admet-2414	1	103	2024	2024	NUM
admet-2414	1	104	;	;	PUNCT
admet-2414	1	105	revised	revise	VERB
admet-2414	1	106	:	:	PUNCT
admet-2414	1	107	october	october	PROPN
admet-2414	1	108	05	05	NUM
admet-2414	1	109	,	,	PUNCT
admet-2414	1	110	2024	2024	NUM
admet-2414	1	111	;	;	PUNCT
admet-2414	1	112	published	publish	VERB
admet-2414	1	113	:	:	PUNCT
admet-2414	1	114	october	october	PROPN
admet-2414	1	115	19	19	NUM
admet-2414	1	116	,	,	PUNCT
admet-2414	1	117	2024	2024	NUM
admet-2414	1	118	abstract	abstract	ADJ
admet-2414	1	119	background	background	NOUN
admet-2414	1	120	and	and	CCONJ
admet-2414	1	121	purpose	purpose	NOUN
admet-2414	1	122	:	:	PUNCT
admet-2414	1	123	the	the	DET
admet-2414	1	124	main	main	ADJ
admet-2414	1	125	features	feature	NOUN
admet-2414	1	126	of	of	ADP
admet-2414	1	127	the	the	DET
admet-2414	1	128	dynamics	dynamic	NOUN
admet-2414	1	129	of	of	ADP
admet-2414	1	130	the	the	DET
admet-2414	1	131	glucocorticoid	glucocorticoid	ADJ
admet-2414	1	132	receptor	receptor	NOUN
admet-2414	1	133	(	(	PUNCT
admet-2414	1	134	gr	gr	NOUN
admet-2414	1	135	)	)	PUNCT
admet-2414	1	136	have	have	AUX
admet-2414	1	137	been	be	AUX
admet-2414	1	138	known	know	VERB
admet-2414	1	139	for	for	ADP
admet-2414	1	140	50	50	NUM
admet-2414	1	141	years	year	NOUN
admet-2414	1	142	:	:	PUNCT
admet-2414	1	143	1	1	X
admet-2414	1	144	)	)	PUNCT
admet-2414	1	145	in	in	ADP
admet-2414	1	146	the	the	DET
admet-2414	1	147	absence	absence	NOUN
admet-2414	1	148	of	of	ADP
admet-2414	1	149	glucocorticoid	glucocorticoid	NOUN
admet-2414	1	150	(	(	PUNCT
admet-2414	1	151	g	g	NOUN
admet-2414	1	152	)	)	PUNCT
admet-2414	1	153	,	,	PUNCT
admet-2414	1	154	the	the	DET
admet-2414	1	155	receptor	receptor	NOUN
admet-2414	1	156	is	be	AUX
admet-2414	1	157	localized	localize	VERB
admet-2414	1	158	entirely	entirely	ADV
admet-2414	1	159	in	in	ADP
admet-2414	1	160	the	the	DET
admet-2414	1	161	cytoplasm	cytoplasm	NOUN
admet-2414	1	162	;	;	PUNCT
admet-2414	1	163	2	2	NUM
admet-2414	1	164	)	)	PUNCT
admet-2414	1	165	upon	upon	SCONJ
admet-2414	1	166	g	g	NOUN
admet-2414	1	167	binding	bind	VERB
admet-2414	1	168	,	,	PUNCT
admet-2414	1	169	gr	gr	NOUN
admet-2414	1	170	is	be	AUX
admet-2414	1	171	converted	convert	VERB
admet-2414	1	172	into	into	ADP
admet-2414	1	173	a	a	DET
admet-2414	1	174	tightly	tightly	ADV
admet-2414	1	175	bound	bind	VERB
admet-2414	1	176	g	g	NOUN
admet-2414	1	177	form	form	NOUN
admet-2414	1	178	and	and	CCONJ
admet-2414	1	179	is	be	AUX
admet-2414	1	180	rapidly	rapidly	ADV
admet-2414	1	181	imported	import	VERB
admet-2414	1	182	into	into	ADP
admet-2414	1	183	the	the	DET
admet-2414	1	184	nucleus	nucleus	NOUN
admet-2414	1	185	where	where	SCONJ
admet-2414	1	186	it	it	PRON
admet-2414	1	187	can	can	AUX
admet-2414	1	188	bind	bind	VERB
admet-2414	1	189	dna	dna	NOUN
admet-2414	1	190	and	and	CCONJ
admet-2414	1	191	modulate	modulate	VERB
admet-2414	1	192	transcription	transcription	NOUN
admet-2414	1	193	;	;	PUNCT
admet-2414	1	194	3	3	X
admet-2414	1	195	)	)	PUNCT
admet-2414	1	196	nuclear	nuclear	ADJ
admet-2414	1	197	export	export	NOUN
admet-2414	1	198	of	of	ADP
admet-2414	1	199	gr	gr	PROPN
admet-2414	1	200	is	be	AUX
admet-2414	1	201	very	very	ADV
admet-2414	1	202	slow	slow	ADJ
admet-2414	1	203	;	;	PUNCT
admet-2414	1	204	and	and	CCONJ
admet-2414	1	205	4	4	X
admet-2414	1	206	)	)	PUNCT
admet-2414	1	207	the	the	DET
admet-2414	1	208	nuclear	nuclear	ADJ
admet-2414	1	209	form	form	NOUN
admet-2414	1	210	of	of	ADP
admet-2414	1	211	gr	gr	PRON
admet-2414	1	212	can	can	AUX
admet-2414	1	213	recycle	recycle	VERB
admet-2414	1	214	through	through	ADP
admet-2414	1	215	an	an	DET
admet-2414	1	216	unbound	unbound	NOUN
admet-2414	1	217	form	form	NOUN
admet-2414	1	218	,	,	PUNCT
admet-2414	1	219	back	back	ADV
admet-2414	1	220	to	to	ADP
admet-2414	1	221	the	the	DET
admet-2414	1	222	bound	bind	VERB
admet-2414	1	223	transcription	transcription	NOUN
admet-2414	1	224	modulating	modulate	VERB
admet-2414	1	225	form	form	NOUN
admet-2414	1	226	without	without	ADP
admet-2414	1	227	leaving	leave	VERB
admet-2414	1	228	the	the	DET
admet-2414	1	229	nucleus	nucleus	NOUN
admet-2414	1	230	.	.	PUNCT
admet-2414	2	1	experimental	experimental	ADJ
admet-2414	2	2	approach	approach	NOUN
admet-2414	2	3	:	:	PUNCT
admet-2414	2	4	a	a	DET
admet-2414	2	5	kinetic	kinetic	ADJ
admet-2414	2	6	model	model	NOUN
admet-2414	2	7	that	that	PRON
admet-2414	2	8	captures	capture	VERB
admet-2414	2	9	these	these	DET
admet-2414	2	10	features	feature	NOUN
admet-2414	2	11	is	be	AUX
admet-2414	2	12	presented	present	VERB
admet-2414	2	13	,	,	PUNCT
admet-2414	2	14	a	a	DET
admet-2414	2	15	set	set	NOUN
admet-2414	2	16	of	of	ADP
admet-2414	2	17	model	model	NOUN
admet-2414	2	18	parameters	parameter	NOUN
admet-2414	2	19	for	for	ADP
admet-2414	2	20	dexamethasone	dexamethasone	NOUN
admet-2414	2	21	is	be	AUX
admet-2414	2	22	derived	derive	VERB
admet-2414	2	23	,	,	PUNCT
admet-2414	2	24	and	and	CCONJ
admet-2414	2	25	the	the	DET
admet-2414	2	26	clinical	clinical	ADJ
admet-2414	2	27	implication	implication	NOUN
admet-2414	2	28	for	for	ADP
admet-2414	2	29	the	the	DET
admet-2414	2	30	commonly	commonly	ADV
admet-2414	2	31	used	use	VERB
admet-2414	2	32	glucocorticoids	glucocorticoid	NOUN
admet-2414	2	33	is	be	AUX
admet-2414	2	34	discussed	discuss	VERB
admet-2414	2	35	.	.	PUNCT
admet-2414	3	1	key	key	ADJ
admet-2414	3	2	results	result	NOUN
admet-2414	3	3	:	:	PUNCT
admet-2414	3	4	at	at	ADP
admet-2414	3	5	the	the	DET
admet-2414	3	6	high	high	ADJ
admet-2414	3	7	concentrations	concentration	NOUN
admet-2414	3	8	normally	normally	ADV
admet-2414	3	9	used	use	VERB
admet-2414	3	10	to	to	PART
admet-2414	3	11	describe	describe	VERB
admet-2414	3	12	g	g	NOUN
admet-2414	3	13	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	3	14	,	,	PUNCT
admet-2414	3	15	the	the	DET
admet-2414	3	16	model	model	NOUN
admet-2414	3	17	reduces	reduce	VERB
admet-2414	3	18	to	to	ADP
admet-2414	3	19	the	the	DET
admet-2414	3	20	standard	standard	ADJ
admet-2414	3	21	michaelis	michaeli	NOUN
admet-2414	3	22	-	-	PUNCT
admet-2414	3	23	menten	menten	ADJ
admet-2414	3	24	equation	equation	NOUN
admet-2414	3	25	with	with	ADP
admet-2414	3	26	a	a	DET
admet-2414	3	27	km	km	NOUN
admet-2414	3	28	that	that	PRON
admet-2414	3	29	is	be	AUX
admet-2414	3	30	a	a	DET
admet-2414	3	31	function	function	NOUN
admet-2414	3	32	of	of	ADP
admet-2414	3	33	4	4	NUM
admet-2414	3	34	model	model	NOUN
admet-2414	3	35	parameters	parameter	NOUN
admet-2414	3	36	.	.	PUNCT
admet-2414	4	1	at	at	ADP
admet-2414	4	2	very	very	ADV
admet-2414	4	3	low	low	ADJ
admet-2414	4	4	concentrations	concentration	NOUN
admet-2414	4	5	,	,	PUNCT
admet-2414	4	6	it	it	PRON
admet-2414	4	7	reduces	reduce	VERB
admet-2414	4	8	to	to	ADP
admet-2414	4	9	another	another	DET
admet-2414	4	10	michaelis	michaelis	ADJ
admet-2414	4	11	-	-	PUNCT
admet-2414	4	12	menten	menten	ADJ
admet-2414	4	13	equation	equation	NOUN
admet-2414	4	14	with	with	ADP
admet-2414	4	15	about	about	ADP
admet-2414	4	16	a	a	DET
admet-2414	4	17	1000	1000	NUM
admet-2414	4	18	-	-	NOUN
admet-2414	4	19	fold	fold	VERB
admet-2414	4	20	greater	great	ADJ
admet-2414	4	21	affinity	affinity	NOUN
admet-2414	4	22	,	,	PUNCT
admet-2414	4	23	eg	eg	NOUN
admet-2414	4	24	.	.	PUNCT
admet-2414	5	1	at	at	ADP
admet-2414	5	2	the	the	DET
admet-2414	5	3	nadir	nadir	NOUN
admet-2414	5	4	human	human	ADJ
admet-2414	5	5	endogenous	endogenous	ADJ
admet-2414	5	6	cortisol	cortisol	ADJ
admet-2414	5	7	concentration	concentration	NOUN
admet-2414	5	8	,	,	PUNCT
admet-2414	5	9	the	the	DET
admet-2414	5	10	full	full	ADJ
admet-2414	5	11	model	model	NOUN
admet-2414	5	12	gr	gr	NOUN
admet-2414	5	13	activity	activity	NOUN
admet-2414	5	14	is	be	AUX
admet-2414	5	15	2.6	2.6	NUM
admet-2414	5	16	times	time	NOUN
admet-2414	5	17	greater	great	ADJ
admet-2414	5	18	than	than	ADP
admet-2414	5	19	that	that	PRON
admet-2414	5	20	predicted	predict	VERB
admet-2414	5	21	by	by	ADP
admet-2414	5	22	extrapolation	extrapolation	NOUN
admet-2414	5	23	of	of	ADP
admet-2414	5	24	the	the	DET
admet-2414	5	25	high	high	ADJ
admet-2414	5	26	concentration	concentration	NOUN
admet-2414	5	27	results	result	NOUN
admet-2414	5	28	.	.	PUNCT
admet-2414	6	1	conclusion	conclusion	NOUN
admet-2414	6	2	:	:	PUNCT
admet-2414	6	3	the	the	DET
admet-2414	6	4	model	model	NOUN
admet-2414	6	5	is	be	AUX
admet-2414	6	6	used	use	VERB
admet-2414	6	7	to	to	PART
admet-2414	6	8	relate	relate	VERB
admet-2414	6	9	normal	normal	ADJ
admet-2414	6	10	human	human	ADJ
admet-2414	6	11	24	24	NUM
admet-2414	6	12	-	-	PUNCT
admet-2414	6	13	hour	hour	NOUN
admet-2414	6	14	endogenous	endogenous	ADJ
admet-2414	6	15	plasma	plasma	NOUN
admet-2414	6	16	cortisol	cortisol	NOUN
admet-2414	6	17	levels	level	NOUN
admet-2414	6	18	to	to	ADP
admet-2414	6	19	transcriptional	transcriptional	ADJ
admet-2414	6	20	activity	activity	NOUN
admet-2414	6	21	and	and	CCONJ
admet-2414	6	22	is	be	AUX
admet-2414	6	23	applied	apply	VERB
admet-2414	6	24	to	to	ADP
admet-2414	6	25	the	the	DET
admet-2414	6	26	commonly	commonly	ADV
admet-2414	6	27	prescribed	prescribe	VERB
admet-2414	6	28	glucocorticoids	glucocorticoid	NOUN
admet-2414	6	29	(	(	PUNCT
admet-2414	6	30	dexamethasone	dexamethasone	NOUN
admet-2414	6	31	,	,	PUNCT
admet-2414	6	32	methylprednisolone	methylprednisolone	NOUN
admet-2414	6	33	,	,	PUNCT
admet-2414	6	34	prednisone	prednisone	NOUN
admet-2414	6	35	)	)	PUNCT
admet-2414	6	36	in	in	ADP
admet-2414	6	37	an	an	DET
admet-2414	6	38	attempt	attempt	NOUN
admet-2414	6	39	to	to	PART
admet-2414	6	40	provide	provide	VERB
admet-2414	6	41	a	a	DET
admet-2414	6	42	pharmacological	pharmacological	ADJ
admet-2414	6	43	rationale	rationale	NOUN
admet-2414	6	44	for	for	ADP
admet-2414	6	45	the	the	DET
admet-2414	6	46	very	very	ADV
admet-2414	6	47	large	large	ADJ
admet-2414	6	48	therapeutic	therapeutic	ADJ
admet-2414	6	49	dosage	dosage	NOUN
admet-2414	6	50	range	range	NOUN
admet-2414	6	51	that	that	PRON
admet-2414	6	52	has	have	AUX
admet-2414	6	53	been	be	AUX
admet-2414	6	54	traditionally	traditionally	ADV
admet-2414	6	55	used	use	VERB
admet-2414	6	56	.	.	PUNCT
admet-2414	7	1	©	©	PROPN
admet-2414	7	2	2024	2024	NUM
admet-2414	7	3	by	by	ADP
admet-2414	7	4	the	the	DET
admet-2414	7	5	authors	author	NOUN
admet-2414	7	6	.	.	PUNCT
admet-2414	8	1	this	this	DET
admet-2414	8	2	article	article	NOUN
admet-2414	8	3	is	be	AUX
admet-2414	8	4	an	an	DET
admet-2414	8	5	open	open	ADJ
admet-2414	8	6	-	-	PUNCT
admet-2414	8	7	access	access	NOUN
admet-2414	8	8	article	article	NOUN
admet-2414	8	9	distributed	distribute	VERB
admet-2414	8	10	under	under	ADP
admet-2414	8	11	the	the	DET
admet-2414	8	12	terms	term	NOUN
admet-2414	8	13	and	and	CCONJ
admet-2414	8	14	conditions	condition	NOUN
admet-2414	8	15	of	of	ADP
admet-2414	8	16	the	the	DET
admet-2414	8	17	creative	creative	ADJ
admet-2414	8	18	commons	common	NOUN
admet-2414	8	19	attribution	attribution	NOUN
admet-2414	8	20	license	license	NOUN
admet-2414	8	21	(	(	PUNCT
admet-2414	8	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2414	8	23	)	)	PUNCT
admet-2414	8	24	.	.	PUNCT
admet-2414	9	1	keywords	keyword	VERB
admet-2414	9	2	dexamethasone	dexamethasone	NOUN
admet-2414	9	3	;	;	PUNCT
admet-2414	9	4	prednisone	prednisone	NOUN
admet-2414	9	5	;	;	PUNCT
admet-2414	9	6	prednisolone	prednisolone	PROPN
admet-2414	9	7	;	;	PUNCT
admet-2414	9	8	methylprednisolone	methylprednisolone	NOUN
admet-2414	9	9	;	;	PUNCT
admet-2414	9	10	cortisol	cortisol	NOUN
admet-2414	9	11	,	,	PUNCT
admet-2414	9	12	transcription	transcription	NOUN
admet-2414	9	13	introduction	introduction	NOUN
admet-2414	9	14	soon	soon	ADV
admet-2414	9	15	after	after	ADP
admet-2414	9	16	the	the	DET
admet-2414	9	17	discovery	discovery	NOUN
admet-2414	9	18	of	of	ADP
admet-2414	9	19	the	the	DET
admet-2414	9	20	glucocorticoid	glucocorticoid	ADJ
admet-2414	9	21	receptor	receptor	NOUN
admet-2414	9	22	(	(	PUNCT
admet-2414	9	23	gr	gr	NOUN
admet-2414	9	24	)	)	PUNCT
admet-2414	9	25	in	in	ADP
admet-2414	9	26	1968	1968	NUM
admet-2414	9	27	[	[	X
admet-2414	9	28	1	1	NUM
admet-2414	9	29	]	]	PUNCT
admet-2414	9	30	,	,	PUNCT
admet-2414	9	31	munck	munck	NOUN
admet-2414	9	32	and	and	CCONJ
admet-2414	9	33	colleagues	colleague	NOUN
admet-2414	9	34	[	[	X
admet-2414	9	35	2,3	2,3	NUM
admet-2414	9	36	]	]	PUNCT
admet-2414	9	37	worked	work	VERB
admet-2414	9	38	out	out	ADP
admet-2414	9	39	the	the	DET
admet-2414	9	40	basic	basic	ADJ
admet-2414	9	41	outlines	outline	NOUN
admet-2414	9	42	of	of	ADP
admet-2414	9	43	its	its	PRON
admet-2414	9	44	mechanism	mechanism	NOUN
admet-2414	9	45	.	.	PUNCT
admet-2414	10	1	upon	upon	SCONJ
admet-2414	10	2	binding	bind	VERB
admet-2414	10	3	of	of	ADP
admet-2414	10	4	the	the	DET
admet-2414	10	5	glucocorticoid	glucocorticoid	NOUN
admet-2414	10	6	(	(	PUNCT
admet-2414	10	7	g	g	NOUN
admet-2414	10	8	)	)	PUNCT
admet-2414	10	9	,	,	PUNCT
admet-2414	10	10	the	the	DET
admet-2414	10	11	gr	gr	NOUN
admet-2414	10	12	undergoes	undergo	VERB
admet-2414	10	13	a	a	DET
admet-2414	10	14	series	series	NOUN
admet-2414	10	15	of	of	ADP
admet-2414	10	16	conformational	conformational	ADJ
admet-2414	10	17	and	and	CCONJ
admet-2414	10	18	locational	locational	ADJ
admet-2414	10	19	changes	change	NOUN
admet-2414	10	20	driven	drive	VERB
admet-2414	10	21	by	by	ADP
admet-2414	10	22	atp	atp	PROPN
admet-2414	10	23	-	-	PUNCT
admet-2414	10	24	dependent	dependent	ADJ
admet-2414	10	25	phosphorylation	phosphorylation	NOUN
admet-2414	10	26	in	in	ADP
admet-2414	10	27	which	which	PRON
admet-2414	10	28	the	the	DET
admet-2414	10	29	g	g	NOUN
admet-2414	10	30	becomes	become	VERB
admet-2414	10	31	tightly	tightly	ADV
admet-2414	10	32	bound	bind	VERB
admet-2414	10	33	deep	deep	ADV
admet-2414	10	34	inside	inside	ADP
admet-2414	10	35	the	the	DET
admet-2414	10	36	receptor	receptor	NOUN
admet-2414	10	37	and	and	CCONJ
admet-2414	10	38	the	the	DET
admet-2414	10	39	receptor	receptor	NOUN
admet-2414	10	40	is	be	AUX
admet-2414	10	41	actively	actively	ADV
admet-2414	10	42	transported	transport	VERB
admet-2414	10	43	into	into	ADP
admet-2414	10	44	the	the	DET
admet-2414	10	45	nucleus	nucleus	NOUN
admet-2414	10	46	where	where	SCONJ
admet-2414	10	47	it	it	PRON
admet-2414	10	48	binds	bind	VERB
admet-2414	10	49	to	to	ADP
admet-2414	10	50	specific	specific	ADJ
admet-2414	10	51	dna	dna	NOUN
admet-2414	10	52	glucocorticoid	glucocorticoid	ADJ
admet-2414	10	53	-	-	PUNCT
admet-2414	10	54	response	response	NOUN
admet-2414	10	55	elements	element	NOUN
admet-2414	10	56	(	(	PUNCT
admet-2414	10	57	gre	gre	PROPN
admet-2414	10	58	)	)	PUNCT
admet-2414	10	59	,	,	PUNCT
admet-2414	10	60	modulating	modulate	VERB
admet-2414	10	61	(	(	PUNCT
admet-2414	10	62	either	either	CCONJ
admet-2414	10	63	increasing	increase	VERB
admet-2414	10	64	or	or	CCONJ
admet-2414	10	65	decreasing	decrease	VERB
admet-2414	10	66	)	)	PUNCT
admet-2414	10	67	transcription	transcription	NOUN
admet-2414	10	68	.	.	PUNCT
admet-2414	11	1	intensive	intensive	ADJ
admet-2414	11	2	investigations	investigation	NOUN
admet-2414	11	3	(	(	PUNCT
admet-2414	11	4	and	and	CCONJ
admet-2414	11	5	a	a	DET
admet-2414	11	6	massive	massive	ADJ
admet-2414	11	7	literature	literature	NOUN
admet-2414	11	8	)	)	PUNCT
admet-2414	11	9	in	in	ADP
admet-2414	11	10	the	the	DET
admet-2414	11	11	following	follow	VERB
admet-2414	11	12	years	year	NOUN
admet-2414	11	13	have	have	AUX
admet-2414	11	14	fleshed	flesh	VERB
admet-2414	11	15	out	out	ADP
admet-2414	11	16	the	the	DET
admet-2414	11	17	details	detail	NOUN
admet-2414	11	18	of	of	ADP
admet-2414	11	19	the	the	DET
admet-2414	11	20	gr	gr	PROPN
admet-2414	11	21	dynamics	dynamic	NOUN
admet-2414	11	22	:	:	PUNCT
admet-2414	11	23	the	the	DET
admet-2414	11	24	atp	atp	PROPN
admet-2414	11	25	-	-	PUNCT
admet-2414	11	26	dependent	dependent	ADJ
admet-2414	11	27	phosphorylation	phosphorylation	NOUN
admet-2414	11	28	events	event	NOUN
admet-2414	11	29	[	[	X
admet-2414	11	30	4	4	NUM
admet-2414	11	31	]	]	PUNCT
admet-2414	11	32	,	,	PUNCT
admet-2414	11	33	the	the	DET
admet-2414	11	34	x	x	ADJ
admet-2414	11	35	-	-	NOUN
admet-2414	11	36	ray	ray	NOUN
admet-2414	11	37	structure	structure	NOUN
admet-2414	11	38	of	of	ADP
admet-2414	11	39	gr	gr	NUM
admet-2414	11	40	with	with	ADP
admet-2414	11	41	a	a	DET
admet-2414	11	42	completely	completely	ADV
admet-2414	11	43	enclosed	enclose	VERB
admet-2414	11	44	tightly	tightly	ADV
admet-2414	11	45	bound	bind	VERB
admet-2414	11	46	g	g	NOUN
admet-2414	11	47	[	[	X
admet-2414	11	48	5	5	NUM
admet-2414	11	49	]	]	PUNCT
admet-2414	11	50	,	,	PUNCT
admet-2414	11	51	the	the	DET
admet-2414	11	52	role	role	NOUN
admet-2414	11	53	of	of	ADP
admet-2414	11	54	chaperone	chaperone	NOUN
admet-2414	11	55	modulation	modulation	NOUN
admet-2414	11	56	of	of	ADP
admet-2414	11	57	gr	gr	NOUN
admet-2414	12	1	[	[	X
admet-2414	12	2	6,7	6,7	NUM
admet-2414	12	3	]	]	PUNCT
admet-2414	12	4	,	,	PUNCT
admet-2414	12	5	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	12	6	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	12	7	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2414	12	8	mailto:levit001@umn.edu	mailto:levit001@umn.edu	VERB
admet-2414	12	9	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2414	12	10	d.	d.	PROPN
admet-2414	12	11	g.	g.	PROPN
admet-2414	12	12	levitt	levitt	PROPN
admet-2414	12	13	admet	admet	PROPN
admet-2414	12	14	&	&	CCONJ
admet-2414	12	15	dmpk	dmpk	PROPN
admet-2414	12	16	12(6	12(6	NUM
admet-2414	12	17	)	)	PUNCT
admet-2414	12	18	(	(	PUNCT
admet-2414	12	19	2024	2024	NUM
admet-2414	12	20	)	)	PUNCT
admet-2414	12	21	971	971	NUM
admet-2414	12	22	-	-	SYM
admet-2414	12	23	989	989	NUM
admet-2414	12	24	972	972	NUM
admet-2414	13	1	the	the	DET
admet-2414	13	2	details	detail	NOUN
admet-2414	13	3	of	of	ADP
admet-2414	13	4	the	the	DET
admet-2414	13	5	gr	gr	ADJ
admet-2414	13	6	-	-	PUNCT
admet-2414	13	7	dna	dna	NOUN
admet-2414	13	8	interactions	interaction	NOUN
admet-2414	13	9	and	and	CCONJ
admet-2414	13	10	transcription	transcription	NOUN
admet-2414	13	11	regulation	regulation	NOUN
admet-2414	13	12	[	[	X
admet-2414	13	13	8	8	NUM
admet-2414	13	14	-	-	SYM
admet-2414	13	15	10	10	NUM
admet-2414	13	16	]	]	PUNCT
admet-2414	13	17	and	and	CCONJ
admet-2414	13	18	the	the	DET
admet-2414	13	19	kinetics	kinetic	NOUN
admet-2414	13	20	of	of	ADP
admet-2414	13	21	the	the	DET
admet-2414	13	22	various	various	ADJ
admet-2414	13	23	conformational	conformational	ADJ
admet-2414	13	24	and	and	CCONJ
admet-2414	13	25	translocational	translocational	ADJ
admet-2414	13	26	steps	step	NOUN
admet-2414	13	27	(	(	PUNCT
admet-2414	13	28	see	see	VERB
admet-2414	13	29	below	below	ADV
admet-2414	13	30	)	)	PUNCT
admet-2414	13	31	.	.	PUNCT
admet-2414	14	1	glucocorticoids	glucocorticoid	NOUN
admet-2414	14	2	are	be	AUX
admet-2414	14	3	some	some	PRON
admet-2414	14	4	of	of	ADP
admet-2414	14	5	the	the	DET
admet-2414	14	6	most	most	ADV
admet-2414	14	7	commonly	commonly	ADV
admet-2414	14	8	prescribed	prescribe	VERB
admet-2414	14	9	drugs	drug	NOUN
admet-2414	14	10	[	[	X
admet-2414	14	11	11	11	NUM
admet-2414	14	12	]	]	PUNCT
admet-2414	14	13	.	.	PUNCT
admet-2414	15	1	they	they	PRON
admet-2414	15	2	have	have	VERB
admet-2414	15	3	an	an	DET
admet-2414	15	4	unusually	unusually	ADV
admet-2414	15	5	high	high	ADJ
admet-2414	15	6	therapeutic	therapeutic	ADJ
admet-2414	15	7	window	window	NOUN
admet-2414	15	8	,	,	PUNCT
admet-2414	15	9	ranging	range	VERB
admet-2414	15	10	from	from	ADP
admet-2414	15	11	low	low	ADJ
admet-2414	15	12	maintenance	maintenance	NOUN
admet-2414	15	13	dosages	dosage	NOUN
admet-2414	15	14	of	of	ADP
admet-2414	15	15	5	5	NUM
admet-2414	15	16	mg	mg	NUM
admet-2414	15	17	/	/	SYM
admet-2414	15	18	day	day	NOUN
admet-2414	15	19	to	to	ADP
admet-2414	15	20	very	very	ADV
admet-2414	15	21	large	large	ADJ
admet-2414	15	22	short	short	ADJ
admet-2414	15	23	-	-	PUNCT
admet-2414	15	24	term	term	NOUN
admet-2414	15	25	dosages	dosage	NOUN
admet-2414	15	26	of	of	ADP
admet-2414	15	27	250	250	NUM
admet-2414	15	28	to	to	PART
admet-2414	15	29	8000	8000	NUM
admet-2414	15	30	mg	mg	PROPN
admet-2414	15	31	/	/	SYM
admet-2414	15	32	day	day	NOUN
admet-2414	15	33	prednisone	prednisone	PROPN
admet-2414	15	34	equivalents	equivalent	NOUN
admet-2414	15	35	[	[	X
admet-2414	15	36	12,13	12,13	NUM
admet-2414	15	37	]	]	PUNCT
admet-2414	15	38	.	.	PUNCT
admet-2414	16	1	the	the	DET
admet-2414	16	2	rationale	rationale	NOUN
admet-2414	16	3	for	for	ADP
admet-2414	16	4	these	these	DET
admet-2414	16	5	dosages	dosage	NOUN
admet-2414	16	6	is	be	AUX
admet-2414	16	7	based	base	VERB
admet-2414	16	8	primarily	primarily	ADV
admet-2414	16	9	on	on	ADP
admet-2414	16	10	traditional	traditional	ADJ
admet-2414	16	11	regimens	regimen	NOUN
admet-2414	16	12	dating	date	VERB
admet-2414	16	13	back	back	ADV
admet-2414	16	14	50	50	NUM
admet-2414	16	15	years	year	NOUN
admet-2414	16	16	or	or	CCONJ
admet-2414	16	17	more	more	ADJ
admet-2414	16	18	[	[	X
admet-2414	16	19	14	14	NUM
admet-2414	16	20	]	]	PUNCT
admet-2414	16	21	,	,	PUNCT
admet-2414	16	22	with	with	ADP
admet-2414	16	23	little	little	ADJ
admet-2414	16	24	reference	reference	NOUN
admet-2414	16	25	to	to	ADP
admet-2414	16	26	the	the	DET
admet-2414	16	27	more	more	ADV
admet-2414	16	28	recent	recent	ADJ
admet-2414	16	29	research	research	NOUN
admet-2414	16	30	on	on	ADP
admet-2414	16	31	glucocorticoid	glucocorticoid	ADJ
admet-2414	16	32	pharmacology	pharmacology	NOUN
admet-2414	16	33	.	.	PUNCT
admet-2414	17	1	considering	consider	VERB
admet-2414	17	2	the	the	DET
admet-2414	17	3	clinical	clinical	ADJ
admet-2414	17	4	importance	importance	NOUN
admet-2414	17	5	of	of	ADP
admet-2414	17	6	the	the	DET
admet-2414	17	7	glucocorticoid	glucocorticoid	ADJ
admet-2414	17	8	pharmacodynamic	pharmacodynamic	ADJ
admet-2414	17	9	(	(	PUNCT
admet-2414	17	10	pd	pd	NOUN
admet-2414	17	11	)	)	PUNCT
admet-2414	17	12	dose	dose	NOUN
admet-2414	17	13	/	/	SYM
admet-2414	17	14	response	response	NOUN
admet-2414	17	15	relationship	relationship	NOUN
admet-2414	17	16	,	,	PUNCT
admet-2414	17	17	it	it	PRON
admet-2414	17	18	is	be	AUX
admet-2414	17	19	surprising	surprising	ADJ
admet-2414	17	20	that	that	SCONJ
admet-2414	17	21	,	,	PUNCT
admet-2414	17	22	seemingly	seemingly	ADV
admet-2414	17	23	,	,	PUNCT
admet-2414	17	24	there	there	PRON
admet-2414	17	25	has	have	AUX
admet-2414	17	26	not	not	PART
admet-2414	17	27	been	be	AUX
admet-2414	17	28	a	a	DET
admet-2414	17	29	previous	previous	ADJ
admet-2414	17	30	attempt	attempt	NOUN
admet-2414	17	31	to	to	PART
admet-2414	17	32	develop	develop	VERB
admet-2414	17	33	a	a	DET
admet-2414	17	34	detailed	detailed	ADJ
admet-2414	17	35	pd	pd	NOUN
admet-2414	17	36	model	model	NOUN
admet-2414	17	37	based	base	VERB
admet-2414	17	38	on	on	ADP
admet-2414	17	39	the	the	DET
admet-2414	17	40	known	know	VERB
admet-2414	17	41	gr	gr	NOUN
admet-2414	17	42	dynamics	dynamic	NOUN
admet-2414	17	43	.	.	PUNCT
admet-2414	18	1	the	the	DET
admet-2414	18	2	purpose	purpose	NOUN
admet-2414	18	3	of	of	ADP
admet-2414	18	4	this	this	DET
admet-2414	18	5	paper	paper	NOUN
admet-2414	18	6	is	be	AUX
admet-2414	18	7	to	to	PART
admet-2414	18	8	develop	develop	VERB
admet-2414	18	9	such	such	DET
admet-2414	18	10	a	a	DET
admet-2414	18	11	model	model	NOUN
admet-2414	18	12	and	and	CCONJ
admet-2414	18	13	describe	describe	VERB
admet-2414	18	14	its	its	PRON
admet-2414	18	15	clinical	clinical	ADJ
admet-2414	18	16	implications	implication	NOUN
admet-2414	18	17	.	.	PUNCT
admet-2414	19	1	the	the	DET
admet-2414	19	2	experimental	experimental	ADJ
admet-2414	19	3	section	section	NOUN
admet-2414	19	4	outlines	outline	VERB
admet-2414	19	5	the	the	DET
admet-2414	19	6	kinetic	kinetic	ADJ
admet-2414	19	7	model	model	NOUN
admet-2414	19	8	and	and	CCONJ
admet-2414	19	9	the	the	DET
admet-2414	19	10	different	different	ADJ
admet-2414	19	11	gr	gr	NOUN
admet-2414	19	12	states	state	NOUN
admet-2414	19	13	.	.	PUNCT
admet-2414	20	1	the	the	DET
admet-2414	20	2	model	model	NOUN
admet-2414	20	3	is	be	AUX
admet-2414	20	4	a	a	DET
admet-2414	20	5	function	function	NOUN
admet-2414	20	6	of	of	ADP
admet-2414	20	7	8	8	NUM
admet-2414	20	8	parameters	parameter	NOUN
admet-2414	20	9	:	:	PUNCT
admet-2414	20	10	2	2	NUM
admet-2414	20	11	equilibrium	equilibrium	NOUN
admet-2414	20	12	constants	constant	NOUN
admet-2414	20	13	and	and	CCONJ
admet-2414	20	14	6	6	NUM
admet-2414	20	15	rate	rate	NOUN
admet-2414	20	16	constants	constant	NOUN
admet-2414	20	17	.	.	PUNCT
admet-2414	21	1	the	the	DET
admet-2414	21	2	experimental	experimental	ADJ
admet-2414	21	3	measurements	measurement	NOUN
admet-2414	21	4	that	that	PRON
admet-2414	21	5	constrain	constrain	VERB
admet-2414	21	6	these	these	DET
admet-2414	21	7	parameters	parameter	NOUN
admet-2414	21	8	are	be	AUX
admet-2414	21	9	described	describe	VERB
admet-2414	21	10	and	and	CCONJ
admet-2414	21	11	an	an	DET
admet-2414	21	12	approximate	approximate	ADJ
admet-2414	21	13	quantitative	quantitative	ADJ
admet-2414	21	14	set	set	NOUN
admet-2414	21	15	of	of	ADP
admet-2414	21	16	values	value	NOUN
admet-2414	21	17	for	for	ADP
admet-2414	21	18	dexamethasone	dexamethasone	NOUN
admet-2414	21	19	(	(	PUNCT
admet-2414	21	20	dex	dex	NOUN
admet-2414	21	21	)	)	PUNCT
admet-2414	21	22	is	be	AUX
admet-2414	21	23	provided	provide	VERB
admet-2414	21	24	.	.	PUNCT
admet-2414	22	1	the	the	DET
admet-2414	22	2	results	result	NOUN
admet-2414	22	3	and	and	CCONJ
admet-2414	22	4	discussion	discussion	NOUN
admet-2414	22	5	section	section	NOUN
admet-2414	22	6	presents	present	VERB
admet-2414	22	7	a	a	DET
admet-2414	22	8	detailed	detailed	ADJ
admet-2414	22	9	description	description	NOUN
admet-2414	22	10	of	of	ADP
admet-2414	22	11	the	the	DET
admet-2414	22	12	steady	steady	ADJ
admet-2414	22	13	state	state	NOUN
admet-2414	22	14	and	and	CCONJ
admet-2414	22	15	time	time	NOUN
admet-2414	22	16	-	-	PUNCT
admet-2414	22	17	dependent	dependent	ADJ
admet-2414	22	18	properties	property	NOUN
admet-2414	22	19	of	of	ADP
admet-2414	22	20	the	the	DET
admet-2414	22	21	model	model	NOUN
admet-2414	22	22	and	and	CCONJ
admet-2414	22	23	the	the	DET
admet-2414	22	24	pd	pd	PROPN
admet-2414	22	25	dose	dose	PROPN
admet-2414	22	26	/	/	SYM
admet-2414	22	27	response	response	NOUN
admet-2414	22	28	for	for	ADP
admet-2414	22	29	the	the	DET
admet-2414	22	30	normal	normal	ADJ
admet-2414	22	31	endogenous	endogenous	ADJ
admet-2414	22	32	human	human	ADJ
admet-2414	22	33	daily	daily	ADJ
admet-2414	22	34	plasma	plasma	NOUN
admet-2414	22	35	cortisol	cortisol	NOUN
admet-2414	22	36	concentration	concentration	NOUN
admet-2414	22	37	.	.	PUNCT
admet-2414	23	1	this	this	DET
admet-2414	23	2	normal	normal	ADJ
admet-2414	23	3	basal	basal	ADJ
admet-2414	23	4	transcriptional	transcriptional	NOUN
admet-2414	23	5	activity	activity	NOUN
admet-2414	23	6	is	be	AUX
admet-2414	23	7	then	then	ADV
admet-2414	23	8	compared	compare	VERB
admet-2414	23	9	with	with	ADP
admet-2414	23	10	that	that	PRON
admet-2414	23	11	produced	produce	VERB
admet-2414	23	12	by	by	ADP
admet-2414	23	13	the	the	DET
admet-2414	23	14	traditional	traditional	ADJ
admet-2414	23	15	dosages	dosage	NOUN
admet-2414	23	16	of	of	ADP
admet-2414	23	17	the	the	DET
admet-2414	23	18	commonly	commonly	ADV
admet-2414	23	19	prescribed	prescribe	VERB
admet-2414	23	20	glucuronides	glucuronide	NOUN
admet-2414	23	21	dexamethasone	dexamethasone	NOUN
admet-2414	23	22	,	,	PUNCT
admet-2414	23	23	methylprednisolone	methylprednisolone	NOUN
admet-2414	23	24	,	,	PUNCT
admet-2414	23	25	and	and	CCONJ
admet-2414	23	26	prednisone	prednisone	NOUN
admet-2414	23	27	.	.	PUNCT
admet-2414	24	1	a	a	DET
admet-2414	24	2	supplementary	supplementary	ADJ
admet-2414	24	3	meterial	meterial	NOUN
admet-2414	24	4	containing	contain	VERB
admet-2414	24	5	two	two	NUM
admet-2414	24	6	supplements	supplement	NOUN
admet-2414	24	7	that	that	PRON
admet-2414	24	8	provide	provide	VERB
admet-2414	24	9	important	important	ADJ
admet-2414	24	10	background	background	NOUN
admet-2414	24	11	information	information	NOUN
admet-2414	24	12	.	.	PUNCT
admet-2414	25	1	supplement	supplement	NOUN
admet-2414	25	2	i	i	PRON
admet-2414	25	3	describes	describe	VERB
admet-2414	25	4	the	the	DET
admet-2414	25	5	details	detail	NOUN
admet-2414	25	6	of	of	ADP
admet-2414	25	7	the	the	DET
admet-2414	25	8	derivation	derivation	NOUN
admet-2414	25	9	of	of	ADP
admet-2414	25	10	the	the	DET
admet-2414	25	11	steady	steady	ADJ
admet-2414	25	12	state	state	NOUN
admet-2414	25	13	and	and	CCONJ
admet-2414	25	14	time	time	NOUN
admet-2414	25	15	-	-	PUNCT
admet-2414	25	16	dependent	dependent	ADJ
admet-2414	25	17	gr	gr	NOUN
admet-2414	25	18	model	model	NOUN
admet-2414	25	19	equations	equation	NOUN
admet-2414	25	20	.	.	PUNCT
admet-2414	26	1	supplement	supplement	NOUN
admet-2414	26	2	ii	ii	PROPN
admet-2414	26	3	describes	describe	VERB
admet-2414	26	4	the	the	DET
admet-2414	26	5	details	detail	NOUN
admet-2414	26	6	of	of	ADP
admet-2414	26	7	the	the	DET
admet-2414	26	8	human	human	ADJ
admet-2414	26	9	pharmacokinetic	pharmacokinetic	ADJ
admet-2414	26	10	(	(	PUNCT
admet-2414	26	11	pk	pk	NOUN
admet-2414	26	12	)	)	PUNCT
admet-2414	26	13	models	model	NOUN
admet-2414	26	14	of	of	ADP
admet-2414	26	15	dexamethasone	dexamethasone	NOUN
admet-2414	26	16	,	,	PUNCT
admet-2414	26	17	methylprednisolone	methylprednisolone	NOUN
admet-2414	26	18	and	and	CCONJ
admet-2414	26	19	prednisone	prednisone	NOUN
admet-2414	26	20	that	that	PRON
admet-2414	26	21	are	be	AUX
admet-2414	26	22	used	use	VERB
admet-2414	26	23	in	in	ADP
admet-2414	26	24	the	the	DET
admet-2414	26	25	main	main	ADJ
admet-2414	26	26	text	text	NOUN
admet-2414	26	27	to	to	PART
admet-2414	26	28	predict	predict	VERB
admet-2414	26	29	the	the	DET
admet-2414	26	30	free	free	ADJ
admet-2414	26	31	plasma	plasma	NOUN
admet-2414	26	32	concentrations	concentration	NOUN
admet-2414	26	33	following	follow	VERB
admet-2414	26	34	arbitrary	arbitrary	ADJ
admet-2414	26	35	intravenous	intravenous	ADJ
admet-2414	26	36	(	(	PUNCT
admet-2414	26	37	iv	iv	NOUN
admet-2414	26	38	)	)	PUNCT
admet-2414	26	39	or	or	CCONJ
admet-2414	26	40	oral	oral	ADJ
admet-2414	26	41	doses	dose	NOUN
admet-2414	26	42	.	.	PUNCT
admet-2414	27	1	although	although	SCONJ
admet-2414	27	2	there	there	PRON
admet-2414	27	3	are	be	VERB
admet-2414	27	4	clearly	clearly	ADV
admet-2414	27	5	some	some	DET
admet-2414	27	6	gr	gr	NOUN
admet-2414	27	7	functions	function	NOUN
admet-2414	27	8	that	that	PRON
admet-2414	27	9	are	be	AUX
admet-2414	27	10	cytoplasmic	cytoplasmic	ADJ
admet-2414	27	11	[	[	X
admet-2414	27	12	15,16	15,16	NUM
admet-2414	27	13	]	]	PUNCT
admet-2414	27	14	,	,	PUNCT
admet-2414	27	15	this	this	DET
admet-2414	27	16	analysis	analysis	NOUN
admet-2414	27	17	is	be	AUX
admet-2414	27	18	focused	focus	VERB
admet-2414	27	19	on	on	ADP
admet-2414	27	20	the	the	DET
admet-2414	27	21	great	great	ADJ
admet-2414	27	22	majority	majority	NOUN
admet-2414	27	23	of	of	ADP
admet-2414	27	24	gr	gr	PRON
admet-2414	27	25	that	that	PRON
admet-2414	27	26	acts	act	VERB
admet-2414	27	27	via	via	ADP
admet-2414	27	28	dna	dna	PROPN
admet-2414	27	29	transcriptional	transcriptional	ADJ
admet-2414	27	30	modulation	modulation	NOUN
admet-2414	27	31	.	.	PUNCT
admet-2414	28	1	in	in	ADP
admet-2414	28	2	discussing	discuss	VERB
admet-2414	28	3	the	the	DET
admet-2414	28	4	cytoplasmic	cytoplasmic	ADJ
admet-2414	28	5	versus	versus	ADP
admet-2414	28	6	nuclear	nuclear	ADJ
admet-2414	28	7	location	location	NOUN
admet-2414	28	8	of	of	ADP
admet-2414	28	9	gr	gr	PROPN
admet-2414	28	10	,	,	PUNCT
admet-2414	28	11	it	it	PRON
admet-2414	28	12	will	will	AUX
admet-2414	28	13	be	be	AUX
admet-2414	28	14	assumed	assume	VERB
admet-2414	28	15	that	that	SCONJ
admet-2414	28	16	all	all	DET
admet-2414	28	17	the	the	DET
admet-2414	28	18	cytoplasmic	cytoplasmic	ADJ
admet-2414	28	19	gr	gr	NOUN
admet-2414	28	20	is	be	AUX
admet-2414	28	21	potentially	potentially	ADV
admet-2414	28	22	destined	destine	VERB
admet-2414	28	23	for	for	ADP
admet-2414	28	24	nuclear	nuclear	ADJ
admet-2414	28	25	import	import	NOUN
admet-2414	28	26	,	,	PUNCT
admet-2414	28	27	whereas	whereas	SCONJ
admet-2414	28	28	,	,	PUNCT
admet-2414	28	29	in	in	ADP
admet-2414	28	30	reality	reality	NOUN
admet-2414	28	31	,	,	PUNCT
admet-2414	28	32	there	there	PRON
admet-2414	28	33	will	will	AUX
admet-2414	28	34	be	be	AUX
admet-2414	28	35	a	a	DET
admet-2414	28	36	small	small	ADJ
admet-2414	28	37	cytoplasmic	cytoplasmic	ADJ
admet-2414	28	38	fraction	fraction	NOUN
admet-2414	28	39	that	that	PRON
admet-2414	28	40	is	be	AUX
admet-2414	28	41	not	not	PART
admet-2414	28	42	associated	associate	VERB
admet-2414	28	43	with	with	ADP
admet-2414	28	44	the	the	DET
admet-2414	28	45	nuclear	nuclear	ADJ
admet-2414	28	46	import	import	NOUN
admet-2414	28	47	biochemistry	biochemistry	NOUN
admet-2414	28	48	.	.	PUNCT
admet-2414	29	1	figure	figure	NOUN
admet-2414	29	2	1	1	NUM
admet-2414	29	3	.	.	PUNCT
admet-2414	30	1	glucocorticoid	glucocorticoid	ADJ
admet-2414	30	2	receptor	receptor	NOUN
admet-2414	30	3	kinetic	kinetic	NOUN
admet-2414	30	4	model	model	NOUN
admet-2414	30	5	.	.	PUNCT
admet-2414	31	1	the	the	DET
admet-2414	31	2	receptor	receptor	NOUN
admet-2414	31	3	cycles	cycle	VERB
admet-2414	31	4	through	through	ADP
admet-2414	31	5	7	7	NUM
admet-2414	31	6	states	state	NOUN
admet-2414	31	7	:	:	PUNCT
admet-2414	31	8	unbound	unbound	NOUN
admet-2414	31	9	in	in	ADP
admet-2414	31	10	the	the	DET
admet-2414	31	11	cytoplasm	cytoplasm	NOUN
admet-2414	31	12	(	(	PUNCT
admet-2414	31	13	rc	rc	PROPN
admet-2414	31	14	)	)	PUNCT
admet-2414	31	15	and	and	CCONJ
admet-2414	31	16	the	the	DET
admet-2414	31	17	nucleus	nucleus	PROPN
admet-2414	31	18	(	(	PUNCT
admet-2414	31	19	rn	rn	PROPN
admet-2414	31	20	)	)	PUNCT
admet-2414	31	21	,	,	PUNCT
admet-2414	31	22	a	a	DET
admet-2414	31	23	loose	loose	ADJ
admet-2414	31	24	equilibrium	equilibrium	NOUN
admet-2414	31	25	g	g	PROPN
admet-2414	31	26	bound	bind	VERB
admet-2414	31	27	form	form	NOUN
admet-2414	31	28	in	in	ADP
admet-2414	31	29	the	the	DET
admet-2414	31	30	cytoplasm	cytoplasm	NOUN
admet-2414	31	31	(	(	PUNCT
admet-2414	31	32	rcg	rcg	NOUN
admet-2414	31	33	)	)	PUNCT
admet-2414	31	34	and	and	CCONJ
admet-2414	31	35	nucleus	nucleus	PROPN
admet-2414	31	36	(	(	PUNCT
admet-2414	31	37	rng	rng	PROPN
admet-2414	31	38	)	)	PUNCT
admet-2414	31	39	,	,	PUNCT
admet-2414	31	40	a	a	DET
admet-2414	31	41	tightly	tightly	ADV
admet-2414	31	42	bound	bind	VERB
admet-2414	31	43	form	form	NOUN
admet-2414	31	44	in	in	ADP
admet-2414	31	45	the	the	DET
admet-2414	31	46	cytoplasm	cytoplasm	ADJ
admet-2414	31	47	(	(	PUNCT
admet-2414	31	48	rcgt	rcgt	PROPN
admet-2414	31	49	)	)	PUNCT
admet-2414	31	50	and	and	CCONJ
admet-2414	31	51	nucleus	nucleus	PROPN
admet-2414	31	52	(	(	PUNCT
admet-2414	31	53	rngt	rngt	PROPN
admet-2414	31	54	)	)	PUNCT
admet-2414	31	55	,	,	PUNCT
admet-2414	31	56	and	and	CCONJ
admet-2414	31	57	the	the	DET
admet-2414	31	58	form	form	NOUN
admet-2414	31	59	that	that	PRON
admet-2414	31	60	can	can	AUX
admet-2414	31	61	bind	bind	VERB
admet-2414	31	62	dna	dna	PROPN
admet-2414	31	63	(	(	PUNCT
admet-2414	31	64	rngn	rngn	PROPN
admet-2414	31	65	)	)	PUNCT
admet-2414	31	66	,	,	PUNCT
admet-2414	31	67	modifying	modify	VERB
admet-2414	31	68	transcription	transcription	NOUN
admet-2414	31	69	.	.	PUNCT
admet-2414	32	1	the	the	DET
admet-2414	32	2	model	model	NOUN
admet-2414	32	3	is	be	AUX
admet-2414	32	4	characterized	characterize	VERB
admet-2414	32	5	by	by	ADP
admet-2414	32	6	two	two	NUM
admet-2414	32	7	equilibrium	equilibrium	NOUN
admet-2414	32	8	binding	bind	VERB
admet-2414	32	9	constants	constant	NOUN
admet-2414	32	10	(	(	PUNCT
admet-2414	32	11	kc	kc	PROPN
admet-2414	32	12	and	and	CCONJ
admet-2414	32	13	kn	kn	PROPN
admet-2414	32	14	)	)	PUNCT
admet-2414	32	15	and	and	CCONJ
admet-2414	32	16	6	6	NUM
admet-2414	32	17	rate	rate	NOUN
admet-2414	32	18	constants	constant	NOUN
admet-2414	32	19	(	(	PUNCT
admet-2414	32	20	k1	k1	NOUN
admet-2414	32	21	to	to	ADP
admet-2414	32	22	k6	k6	PROPN
admet-2414	32	23	)	)	PUNCT
admet-2414	32	24	admet	admet	PROPN
admet-2414	32	25	&	&	CCONJ
admet-2414	32	26	dmpk	dmpk	PROPN
admet-2414	32	27	12(6	12(6	NUM
admet-2414	32	28	)	)	PUNCT
admet-2414	32	29	(	(	PUNCT
admet-2414	32	30	2024	2024	NUM
admet-2414	32	31	)	)	PUNCT
admet-2414	32	32	971	971	NUM
admet-2414	32	33	-	-	SYM
admet-2414	32	34	989	989	NUM
admet-2414	32	35	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	32	36	/	/	SYM
admet-2414	32	37	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	32	38	of	of	ADP
admet-2414	32	39	glucocorticoids	glucocorticoid	NOUN
admet-2414	32	40	doi	doi	NOUN
admet-2414	32	41	:	:	PUNCT
admet-2414	32	42	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	32	43	973	973	NUM
admet-2414	32	44	experimental	experimental	ADJ
admet-2414	32	45	glucocorticoid	glucocorticoid	ADJ
admet-2414	32	46	receptor	receptor	NOUN
admet-2414	32	47	kinetic	kinetic	NOUN
admet-2414	32	48	model	model	NOUN
admet-2414	32	49	the	the	DET
admet-2414	32	50	kinetic	kinetic	ADJ
admet-2414	32	51	model	model	NOUN
admet-2414	32	52	is	be	AUX
admet-2414	32	53	shown	show	VERB
admet-2414	32	54	in	in	ADP
admet-2414	32	55	figure	figure	NOUN
admet-2414	32	56	1	1	NUM
admet-2414	32	57	.	.	PUNCT
admet-2414	33	1	the	the	DET
admet-2414	33	2	receptor	receptor	NOUN
admet-2414	33	3	has	have	VERB
admet-2414	33	4	7	7	NUM
admet-2414	33	5	different	different	ADJ
admet-2414	33	6	states	state	NOUN
admet-2414	33	7	:	:	PUNCT
admet-2414	33	8	unbound	unbound	NOUN
admet-2414	33	9	in	in	ADP
admet-2414	33	10	the	the	DET
admet-2414	33	11	cytoplasm	cytoplasm	NOUN
admet-2414	33	12	(	(	PUNCT
admet-2414	33	13	rc	rc	PROPN
admet-2414	33	14	)	)	PUNCT
admet-2414	33	15	and	and	CCONJ
admet-2414	33	16	the	the	DET
admet-2414	33	17	nucleus	nucleus	PROPN
admet-2414	33	18	(	(	PUNCT
admet-2414	33	19	rn	rn	PROPN
admet-2414	33	20	)	)	PUNCT
admet-2414	33	21	,	,	PUNCT
admet-2414	33	22	a	a	DET
admet-2414	33	23	loose	loose	ADJ
admet-2414	33	24	equilibrium	equilibrium	NOUN
admet-2414	33	25	g	g	PROPN
admet-2414	33	26	bound	bind	VERB
admet-2414	33	27	form	form	NOUN
admet-2414	33	28	in	in	ADP
admet-2414	33	29	the	the	DET
admet-2414	33	30	cytoplasm	cytoplasm	NOUN
admet-2414	33	31	(	(	PUNCT
admet-2414	33	32	rcg	rcg	NOUN
admet-2414	33	33	)	)	PUNCT
admet-2414	33	34	and	and	CCONJ
admet-2414	33	35	nucleus	nucleus	PROPN
admet-2414	33	36	(	(	PUNCT
admet-2414	33	37	rng	rng	PROPN
admet-2414	33	38	)	)	PUNCT
admet-2414	33	39	,	,	PUNCT
admet-2414	33	40	a	a	DET
admet-2414	33	41	tightly	tightly	ADV
admet-2414	33	42	bound	bind	VERB
admet-2414	33	43	form	form	NOUN
admet-2414	33	44	in	in	ADP
admet-2414	33	45	the	the	DET
admet-2414	33	46	cytoplasm	cytoplasm	ADJ
admet-2414	33	47	(	(	PUNCT
admet-2414	33	48	rcgt	rcgt	PROPN
admet-2414	33	49	)	)	PUNCT
admet-2414	33	50	and	and	CCONJ
admet-2414	33	51	nucleus	nucleus	PROPN
admet-2414	33	52	(	(	PUNCT
admet-2414	33	53	rngt	rngt	PROPN
admet-2414	33	54	)	)	PUNCT
admet-2414	33	55	,	,	PUNCT
admet-2414	33	56	and	and	CCONJ
admet-2414	33	57	the	the	DET
admet-2414	33	58	form	form	NOUN
admet-2414	33	59	that	that	PRON
admet-2414	33	60	can	can	AUX
admet-2414	33	61	bind	bind	VERB
admet-2414	33	62	dna	dna	PROPN
admet-2414	33	63	(	(	PUNCT
admet-2414	33	64	rngn	rngn	PROPN
admet-2414	33	65	)	)	PUNCT
admet-2414	33	66	,	,	PUNCT
admet-2414	33	67	modifying	modify	VERB
admet-2414	33	68	transcription	transcription	NOUN
admet-2414	33	69	.	.	PUNCT
admet-2414	34	1	the	the	DET
admet-2414	34	2	model	model	NOUN
admet-2414	34	3	approximates	approximate	VERB
admet-2414	34	4	the	the	DET
admet-2414	34	5	reaction	reaction	NOUN
admet-2414	34	6	pathway	pathway	NOUN
admet-2414	34	7	and	and	CCONJ
admet-2414	34	8	conformational	conformational	ADJ
admet-2414	34	9	states	state	NOUN
admet-2414	34	10	described	describe	VERB
admet-2414	34	11	by	by	ADP
admet-2414	34	12	pratt	pratt	PROPN
admet-2414	34	13	et	et	PROPN
admet-2414	34	14	al	al	PROPN
admet-2414	34	15	.	.	PUNCT
admet-2414	35	1	[	[	X
admet-2414	35	2	7	7	NUM
admet-2414	35	3	]	]	PUNCT
admet-2414	35	4	.	.	PUNCT
admet-2414	36	1	it	it	PRON
admet-2414	36	2	is	be	AUX
admet-2414	36	3	a	a	DET
admet-2414	36	4	simplified	simplified	ADJ
admet-2414	36	5	version	version	NOUN
admet-2414	36	6	of	of	ADP
admet-2414	36	7	the	the	DET
admet-2414	36	8	actual	actual	ADJ
admet-2414	36	9	glucocorticoid	glucocorticoid	ADJ
admet-2414	36	10	receptor	receptor	NOUN
admet-2414	36	11	dynamics	dynamic	NOUN
admet-2414	36	12	because	because	SCONJ
admet-2414	36	13	the	the	DET
admet-2414	36	14	multiple	multiple	ADJ
admet-2414	36	15	chaperones	chaperone	NOUN
admet-2414	36	16	and	and	CCONJ
admet-2414	36	17	cofactors	cofactor	NOUN
admet-2414	36	18	that	that	PRON
admet-2414	36	19	are	be	AUX
admet-2414	36	20	bound	bind	VERB
admet-2414	36	21	to	to	ADP
admet-2414	36	22	the	the	DET
admet-2414	36	23	receptor	receptor	NOUN
admet-2414	36	24	in	in	ADP
admet-2414	36	25	the	the	DET
admet-2414	36	26	different	different	ADJ
admet-2414	36	27	states	state	NOUN
admet-2414	36	28	are	be	AUX
admet-2414	36	29	not	not	PART
admet-2414	36	30	included	include	VERB
admet-2414	36	31	.	.	PUNCT
admet-2414	37	1	each	each	DET
admet-2414	37	2	reaction	reaction	NOUN
admet-2414	37	3	in	in	ADP
admet-2414	37	4	figure	figure	NOUN
admet-2414	37	5	1	1	NUM
admet-2414	37	6	presumably	presumably	ADV
admet-2414	37	7	consists	consist	VERB
admet-2414	37	8	of	of	ADP
admet-2414	37	9	a	a	DET
admet-2414	37	10	series	series	NOUN
admet-2414	37	11	of	of	ADP
admet-2414	37	12	reactions	reaction	NOUN
admet-2414	37	13	as	as	SCONJ
admet-2414	37	14	the	the	DET
admet-2414	37	15	cofactors	cofactor	NOUN
admet-2414	37	16	are	be	AUX
admet-2414	37	17	assembled	assemble	VERB
admet-2414	37	18	or	or	CCONJ
admet-2414	37	19	disassembled	disassemble	VERB
admet-2414	37	20	.	.	PUNCT
admet-2414	38	1	it	it	PRON
admet-2414	38	2	is	be	AUX
admet-2414	38	3	hoped	hope	VERB
admet-2414	38	4	that	that	SCONJ
admet-2414	38	5	the	the	DET
admet-2414	38	6	model	model	NOUN
admet-2414	38	7	in	in	ADP
admet-2414	38	8	figure	figure	NOUN
admet-2414	38	9	1	1	NUM
admet-2414	38	10	captures	capture	VERB
admet-2414	38	11	the	the	DET
admet-2414	38	12	essential	essential	ADJ
admet-2414	38	13	features	feature	NOUN
admet-2414	38	14	of	of	ADP
admet-2414	38	15	the	the	DET
admet-2414	38	16	kinetics	kinetic	NOUN
admet-2414	38	17	.	.	PUNCT
admet-2414	39	1	the	the	DET
admet-2414	39	2	single	single	ADJ
admet-2414	39	3	-	-	PUNCT
admet-2414	39	4	headed	head	VERB
admet-2414	39	5	arrows	arrow	NOUN
admet-2414	39	6	represent	represent	VERB
admet-2414	39	7	irreversible	irreversible	ADJ
admet-2414	39	8	unidirectional	unidirectional	ADJ
admet-2414	39	9	transitions	transition	NOUN
admet-2414	39	10	driven	drive	VERB
admet-2414	39	11	either	either	CCONJ
admet-2414	39	12	by	by	ADP
admet-2414	39	13	atp	atp	PROPN
admet-2414	39	14	phosphorylation	phosphorylation	NOUN
admet-2414	39	15	and/or	and/or	CCONJ
admet-2414	39	16	chaperone	chaperone	NOUN
admet-2414	39	17	-	-	PUNCT
admet-2414	39	18	driven	drive	VERB
admet-2414	39	19	conformational	conformational	ADJ
admet-2414	39	20	changes	change	NOUN
admet-2414	39	21	.	.	PUNCT
admet-2414	40	1	the	the	DET
admet-2414	40	2	initial	initial	ADJ
admet-2414	40	3	binding	binding	NOUN
admet-2414	40	4	of	of	ADP
admet-2414	40	5	g	g	PROPN
admet-2414	40	6	(	(	PUNCT
admet-2414	40	7	characterized	characterize	VERB
admet-2414	40	8	by	by	ADP
admet-2414	40	9	equilibrium	equilibrium	NOUN
admet-2414	40	10	constants	constant	NOUN
admet-2414	40	11	kc	kc	PROPN
admet-2414	40	12	and	and	CCONJ
admet-2414	40	13	kn	kn	PROPN
admet-2414	40	14	)	)	PUNCT
admet-2414	40	15	drives	drive	VERB
admet-2414	40	16	gr	gr	NOUN
admet-2414	40	17	into	into	ADP
admet-2414	40	18	a	a	DET
admet-2414	40	19	tightly	tightly	ADV
admet-2414	40	20	bound	bind	VERB
admet-2414	40	21	conformation	conformation	NOUN
admet-2414	40	22	(	(	PUNCT
admet-2414	40	23	at	at	ADP
admet-2414	40	24	rate	rate	NOUN
admet-2414	40	25	constants	constant	NOUN
admet-2414	40	26	k1	k1	NOUN
admet-2414	40	27	and	and	CCONJ
admet-2414	40	28	k6	k6	NOUN
admet-2414	40	29	)	)	PUNCT
admet-2414	40	30	in	in	ADP
admet-2414	40	31	which	which	PRON
admet-2414	40	32	the	the	DET
admet-2414	40	33	g	g	NOUN
admet-2414	40	34	is	be	AUX
admet-2414	40	35	buried	bury	VERB
admet-2414	40	36	deep	deep	ADV
admet-2414	40	37	in	in	ADP
admet-2414	40	38	the	the	DET
admet-2414	40	39	protein	protein	NOUN
admet-2414	40	40	[	[	X
admet-2414	40	41	5	5	NUM
admet-2414	40	42	]	]	PUNCT
admet-2414	40	43	.	.	PUNCT
admet-2414	41	1	the	the	DET
admet-2414	41	2	nuclear	nuclear	ADJ
admet-2414	41	3	import	import	NOUN
admet-2414	41	4	and	and	CCONJ
admet-2414	41	5	export	export	NOUN
admet-2414	41	6	(	(	PUNCT
admet-2414	41	7	characterized	characterize	VERB
admet-2414	41	8	by	by	ADP
admet-2414	41	9	the	the	DET
admet-2414	41	10	rate	rate	NOUN
admet-2414	41	11	constants	constant	NOUN
admet-2414	41	12	k2	k2	PROPN
admet-2414	41	13	and	and	CCONJ
admet-2414	41	14	k5	k5	PROPN
admet-2414	41	15	)	)	PUNCT
admet-2414	41	16	are	be	AUX
admet-2414	41	17	complex	complex	ADJ
admet-2414	41	18	energy	energy	NOUN
admet-2414	41	19	-	-	PUNCT
admet-2414	41	20	dependent	dependent	ADJ
admet-2414	41	21	processes	process	NOUN
admet-2414	41	22	involving	involve	VERB
admet-2414	41	23	dynein	dynein	NOUN
admet-2414	41	24	,	,	PUNCT
admet-2414	41	25	the	the	DET
admet-2414	41	26	nuclear	nuclear	ADJ
admet-2414	41	27	pore	pore	ADJ
admet-2414	41	28	complex	complex	NOUN
admet-2414	41	29	and	and	CCONJ
admet-2414	41	30	a	a	DET
admet-2414	41	31	variety	variety	NOUN
admet-2414	41	32	of	of	ADP
admet-2414	41	33	chaperones	chaperone	NOUN
admet-2414	41	34	and	and	CCONJ
admet-2414	41	35	accessory	accessory	ADJ
admet-2414	41	36	proteins	protein	NOUN
admet-2414	41	37	[	[	X
admet-2414	41	38	6	6	NUM
admet-2414	41	39	]	]	PUNCT
admet-2414	41	40	.	.	PUNCT
admet-2414	42	1	the	the	DET
admet-2414	42	2	only	only	ADJ
admet-2414	42	3	states	state	NOUN
admet-2414	42	4	in	in	ADP
admet-2414	42	5	which	which	PRON
admet-2414	42	6	there	there	PRON
admet-2414	42	7	is	be	VERB
admet-2414	42	8	reversible	reversible	ADJ
admet-2414	42	9	g	g	NOUN
admet-2414	42	10	binding	bind	VERB
admet-2414	42	11	is	be	AUX
admet-2414	42	12	rc	rc	PROPN
admet-2414	42	13			NOUN
admet-2414	42	14	rcg	rcg	PROPN
admet-2414	42	15	and	and	CCONJ
admet-2414	42	16	rn	rn	PROPN
admet-2414	42	17			PROPN
admet-2414	42	18	rng	rng	PROPN
admet-2414	42	19	.	.	PUNCT
admet-2414	43	1	for	for	ADP
admet-2414	43	2	all	all	DET
admet-2414	43	3	the	the	DET
admet-2414	43	4	other	other	ADJ
admet-2414	43	5	states	state	NOUN
admet-2414	43	6	,	,	PUNCT
admet-2414	43	7	the	the	DET
admet-2414	43	8	g	g	NOUN
admet-2414	43	9	is	be	AUX
admet-2414	43	10	buried	bury	VERB
admet-2414	43	11	deep	deep	ADV
admet-2414	43	12	inside	inside	ADP
admet-2414	43	13	the	the	DET
admet-2414	43	14	protein	protein	NOUN
admet-2414	43	15	and	and	CCONJ
admet-2414	43	16	can	can	AUX
admet-2414	43	17	not	not	PART
admet-2414	43	18	exchange	exchange	VERB
admet-2414	43	19	.	.	PUNCT
admet-2414	44	1	the	the	DET
admet-2414	44	2	nuclear	nuclear	ADJ
admet-2414	44	3	form	form	NOUN
admet-2414	44	4	of	of	ADP
admet-2414	44	5	the	the	DET
admet-2414	44	6	receptor	receptor	NOUN
admet-2414	44	7	(	(	PUNCT
admet-2414	44	8	rngt	rngt	PROPN
admet-2414	44	9	)	)	PUNCT
admet-2414	44	10	is	be	AUX
admet-2414	44	11	converted	convert	VERB
admet-2414	44	12	to	to	ADP
admet-2414	44	13	the	the	DET
admet-2414	44	14	form	form	NOUN
admet-2414	44	15	rngn	rngn	NOUN
admet-2414	44	16	(	(	PUNCT
admet-2414	44	17	at	at	ADP
admet-2414	44	18	rate	rate	NOUN
admet-2414	44	19	constant	constant	ADJ
admet-2414	44	20	k3	k3	NOUN
admet-2414	44	21	)	)	PUNCT
admet-2414	44	22	,	,	PUNCT
admet-2414	44	23	which	which	PRON
admet-2414	44	24	can	can	AUX
admet-2414	44	25	potentially	potentially	ADV
admet-2414	44	26	interact	interact	VERB
admet-2414	44	27	with	with	ADP
admet-2414	44	28	dna	dna	NOUN
admet-2414	44	29	and	and	CCONJ
admet-2414	44	30	modulate	modulate	VERB
admet-2414	44	31	transcription	transcription	NOUN
admet-2414	44	32	.	.	PUNCT
admet-2414	45	1	for	for	ADP
admet-2414	45	2	a	a	DET
admet-2414	45	3	complete	complete	ADJ
admet-2414	45	4	model	model	NOUN
admet-2414	45	5	description	description	NOUN
admet-2414	45	6	,	,	PUNCT
admet-2414	45	7	one	one	PRON
admet-2414	45	8	must	must	AUX
admet-2414	45	9	also	also	ADV
admet-2414	45	10	specify	specify	VERB
admet-2414	45	11	the	the	DET
admet-2414	45	12	total	total	ADJ
admet-2414	45	13	amount	amount	NOUN
admet-2414	45	14	of	of	ADP
admet-2414	45	15	receptor	receptor	NOUN
admet-2414	45	16	(	(	PUNCT
admet-2414	45	17	rtot	rtot	NOUN
admet-2414	45	18	)	)	PUNCT
admet-2414	45	19	.	.	PUNCT
admet-2414	46	1	the	the	DET
admet-2414	46	2	following	follow	VERB
admet-2414	46	3	analysis	analysis	NOUN
admet-2414	46	4	is	be	AUX
admet-2414	46	5	primarily	primarily	ADV
admet-2414	46	6	focused	focus	VERB
admet-2414	46	7	on	on	ADP
admet-2414	46	8	,	,	PUNCT
admet-2414	46	9	e.g.	e.g.	ADV
admet-2414	46	10	the	the	DET
admet-2414	46	11	concentration	concentration	NOUN
admet-2414	46	12	dependence	dependence	NOUN
admet-2414	46	13	of	of	ADP
admet-2414	46	14	the	the	DET
admet-2414	46	15	transcriptional	transcriptional	ADJ
admet-2414	46	16	rate	rate	NOUN
admet-2414	46	17	relative	relative	ADJ
admet-2414	46	18	to	to	ADP
admet-2414	46	19	the	the	DET
admet-2414	46	20	maximum	maximum	ADJ
admet-2414	46	21	rate	rate	NOUN
admet-2414	46	22	at	at	ADP
admet-2414	46	23	very	very	ADV
admet-2414	46	24	high	high	ADJ
admet-2414	46	25	g	g	NOUN
admet-2414	46	26	concentration	concentration	NOUN
admet-2414	46	27	.	.	PUNCT
admet-2414	47	1	for	for	ADP
admet-2414	47	2	this	this	DET
admet-2414	47	3	case	case	NOUN
admet-2414	47	4	,	,	PUNCT
admet-2414	47	5	rtot	rtot	NOUN
admet-2414	47	6	is	be	AUX
admet-2414	47	7	just	just	ADV
admet-2414	47	8	a	a	DET
admet-2414	47	9	scaling	scale	VERB
admet-2414	47	10	factor	factor	NOUN
admet-2414	47	11	that	that	PRON
admet-2414	47	12	can	can	AUX
admet-2414	47	13	simply	simply	ADV
admet-2414	47	14	be	be	AUX
admet-2414	47	15	set	set	VERB
admet-2414	47	16	to	to	ADP
admet-2414	47	17	1	1	NUM
admet-2414	47	18	.	.	PUNCT
admet-2414	48	1	a	a	DET
admet-2414	48	2	crucial	crucial	ADJ
admet-2414	48	3	aspect	aspect	NOUN
admet-2414	48	4	of	of	ADP
admet-2414	48	5	the	the	DET
admet-2414	48	6	model	model	NOUN
admet-2414	48	7	is	be	AUX
admet-2414	48	8	that	that	SCONJ
admet-2414	48	9	the	the	DET
admet-2414	48	10	receptor	receptor	NOUN
admet-2414	48	11	can	can	AUX
admet-2414	48	12	recycle	recycle	VERB
admet-2414	48	13	from	from	ADP
admet-2414	48	14	the	the	DET
admet-2414	48	15	active	active	ADJ
admet-2414	48	16	form	form	NOUN
admet-2414	48	17	(	(	PUNCT
admet-2414	48	18	rngn	rngn	PROPN
admet-2414	48	19	)	)	PUNCT
admet-2414	48	20	,	,	PUNCT
admet-2414	48	21	through	through	ADP
admet-2414	48	22	the	the	DET
admet-2414	48	23	free	free	ADJ
admet-2414	48	24	nuclear	nuclear	ADJ
admet-2414	48	25	form	form	NOUN
admet-2414	48	26	rn	rn	PROPN
admet-2414	48	27	(	(	PUNCT
admet-2414	48	28	rate	rate	NOUN
admet-2414	48	29	constant	constant	ADJ
admet-2414	48	30	k4	k4	NOUN
admet-2414	48	31	)	)	PUNCT
admet-2414	48	32	back	back	ADV
admet-2414	48	33	to	to	ADP
admet-2414	48	34	the	the	DET
admet-2414	48	35	active	active	ADJ
admet-2414	48	36	form	form	NOUN
admet-2414	48	37	(	(	PUNCT
admet-2414	48	38	rate	rate	NOUN
admet-2414	48	39	constants	constant	NOUN
admet-2414	48	40	k6	k6	NOUN
admet-2414	48	41	and	and	CCONJ
admet-2414	48	42	k3	k3	PROPN
admet-2414	48	43	)	)	PUNCT
admet-2414	48	44	without	without	ADP
admet-2414	48	45	leaving	leave	VERB
admet-2414	48	46	the	the	DET
admet-2414	48	47	nucle	nucle	NOUN
admet-2414	48	48	us	we	PRON
admet-2414	49	1	[	[	X
admet-2414	49	2	17	17	NUM
admet-2414	49	3	-	-	SYM
admet-2414	49	4	19	19	NUM
admet-2414	49	5	]	]	PUNCT
admet-2414	49	6	.	.	PUNCT
admet-2414	50	1	since	since	SCONJ
admet-2414	50	2	most	most	ADJ
admet-2414	50	3	of	of	ADP
admet-2414	50	4	the	the	DET
admet-2414	50	5	receptor	receptor	NOUN
admet-2414	50	6	is	be	AUX
admet-2414	50	7	in	in	ADP
admet-2414	50	8	the	the	DET
admet-2414	50	9	nucleus	nucleus	NOUN
admet-2414	50	10	even	even	ADV
admet-2414	50	11	at	at	ADP
admet-2414	50	12	low	low	ADJ
admet-2414	50	13	glucocorticoid	glucocorticoid	ADJ
admet-2414	50	14	concentrations	concentration	NOUN
admet-2414	50	15	,	,	PUNCT
admet-2414	50	16	this	this	PRON
admet-2414	50	17	implies	imply	VERB
admet-2414	50	18	that	that	SCONJ
admet-2414	50	19	the	the	DET
admet-2414	50	20	active	active	ADJ
admet-2414	50	21	rngn	rngn	NOUN
admet-2414	50	22	state	state	NOUN
admet-2414	50	23	is	be	AUX
admet-2414	50	24	determined	determine	VERB
admet-2414	50	25	primarily	primarily	ADV
admet-2414	50	26	by	by	ADP
admet-2414	50	27	the	the	DET
admet-2414	50	28	nuclear	nuclear	ADJ
admet-2414	50	29	receptor	receptor	NOUN
admet-2414	50	30	affinity	affinity	NOUN
admet-2414	50	31	(	(	PUNCT
admet-2414	50	32	kn	kn	PROPN
admet-2414	50	33	)	)	PUNCT
admet-2414	50	34	,	,	PUNCT
admet-2414	50	35	not	not	PART
admet-2414	50	36	the	the	DET
admet-2414	50	37	cytoplasmic	cytoplasmic	ADJ
admet-2414	50	38	affinity	affinity	NOUN
admet-2414	50	39	(	(	PUNCT
admet-2414	50	40	kc	kc	PROPN
admet-2414	50	41	)	)	PUNCT
admet-2414	50	42	.	.	PUNCT
admet-2414	51	1	estimates	estimate	NOUN
admet-2414	51	2	of	of	ADP
admet-2414	51	3	model	model	NOUN
admet-2414	51	4	parameters	parameter	NOUN
admet-2414	51	5	this	this	DET
admet-2414	51	6	section	section	NOUN
admet-2414	51	7	describes	describe	VERB
admet-2414	51	8	an	an	DET
admet-2414	51	9	estimate	estimate	NOUN
admet-2414	51	10	of	of	ADP
admet-2414	51	11	the	the	DET
admet-2414	51	12	model	model	NOUN
admet-2414	51	13	parameter	parameter	NOUN
admet-2414	51	14	values	value	NOUN
admet-2414	51	15	(	(	PUNCT
admet-2414	51	16	table	table	NOUN
admet-2414	51	17	1	1	NUM
admet-2414	51	18	)	)	PUNCT
admet-2414	51	19	for	for	ADP
admet-2414	51	20	dex	dex	NOUN
admet-2414	51	21	,	,	PUNCT
admet-2414	51	22	the	the	DET
admet-2414	51	23	commonly	commonly	ADV
admet-2414	51	24	used	use	VERB
admet-2414	51	25	glucuronide	glucuronide	ADV
admet-2414	51	26	in	in	ADP
admet-2414	51	27	gr	gr	PROPN
admet-2414	51	28	mechanistic	mechanistic	ADJ
admet-2414	51	29	studies	study	NOUN
admet-2414	51	30	.	.	PUNCT
admet-2414	52	1	the	the	DET
admet-2414	52	2	rate	rate	NOUN
admet-2414	52	3	constants	constant	NOUN
admet-2414	52	4	for	for	ADP
admet-2414	52	5	nuclear	nuclear	ADJ
admet-2414	52	6	import	import	NOUN
admet-2414	52	7	(	(	PUNCT
admet-2414	52	8	k2	k2	NOUN
admet-2414	52	9	)	)	PUNCT
admet-2414	52	10	and	and	CCONJ
admet-2414	52	11	export	export	NOUN
admet-2414	52	12	(	(	PUNCT
admet-2414	52	13	k5	k5	PROPN
admet-2414	52	14	)	)	PUNCT
admet-2414	52	15	were	be	AUX
admet-2414	52	16	measured	measure	VERB
admet-2414	52	17	in	in	ADP
admet-2414	52	18	older	old	ADJ
admet-2414	52	19	studies	study	NOUN
admet-2414	52	20	by	by	ADP
admet-2414	52	21	following	follow	VERB
admet-2414	52	22	the	the	DET
admet-2414	52	23	movement	movement	NOUN
admet-2414	52	24	of	of	ADP
admet-2414	52	25	tritiated	tritiate	VERB
admet-2414	52	26	labeled	label	VERB
admet-2414	52	27	glucocorticoid	glucocorticoid	NOUN
admet-2414	52	28	bound	bind	VERB
admet-2414	52	29	to	to	PART
admet-2414	52	30	receptor	receptor	VERB
admet-2414	52	31	[	[	X
admet-2414	52	32	20	20	NUM
admet-2414	52	33	]	]	PUNCT
admet-2414	52	34	and	and	CCONJ
admet-2414	52	35	,	,	PUNCT
admet-2414	52	36	more	more	ADV
admet-2414	52	37	recently	recently	ADV
admet-2414	52	38	,	,	PUNCT
admet-2414	52	39	by	by	ADP
admet-2414	52	40	imaging	imaging	NOUN
admet-2414	52	41	of	of	ADP
admet-2414	52	42	green	green	ADJ
admet-2414	52	43	fluorescent	fluorescent	ADJ
admet-2414	52	44	protein	protein	NOUN
admet-2414	52	45	fused	fuse	VERB
admet-2414	52	46	gr	gr	ADP
admet-2414	52	47	(	(	PUNCT
admet-2414	52	48	gfp	gfp	PROPN
admet-2414	52	49	-	-	PUNCT
admet-2414	52	50	gr	gr	NOUN
admet-2414	52	51	)	)	PUNCT
admet-2414	53	1	[	[	X
admet-2414	53	2	6,21	6,21	NUM
admet-2414	53	3	-	-	SYM
admet-2414	53	4	23	23	NUM
admet-2414	53	5	]	]	PUNCT
admet-2414	53	6	or	or	CCONJ
admet-2414	53	7	immunofluorescence	immunofluorescence	NOUN
admet-2414	53	8	[	[	X
admet-2414	53	9	19,24	19,24	X
admet-2414	53	10	]	]	X
admet-2414	53	11	.	.	PUNCT
admet-2414	54	1	the	the	DET
admet-2414	54	2	rate	rate	NOUN
admet-2414	54	3	of	of	ADP
admet-2414	54	4	nuclear	nuclear	ADJ
admet-2414	54	5	import	import	NOUN
admet-2414	54	6	is	be	AUX
admet-2414	54	7	fast	fast	ADJ
admet-2414	54	8	,	,	PUNCT
admet-2414	54	9	with	with	ADP
admet-2414	54	10	a	a	DET
admet-2414	54	11	time	time	NOUN
admet-2414	54	12	constant	constant	ADJ
admet-2414	54	13	of	of	ADP
admet-2414	54	14	about	about	ADV
admet-2414	54	15	5	5	NUM
admet-2414	54	16	min	min	NOUN
admet-2414	54	17	(	(	PUNCT
admet-2414	54	18	k2	k2	NOUN
admet-2414	54	19	=	=	PROPN
admet-2414	54	20	0.2	0.2	NUM
admet-2414	54	21	min-1	min-1	NUM
admet-2414	54	22	)	)	PUNCT
admet-2414	54	23	,	,	PUNCT
admet-2414	54	24	while	while	SCONJ
admet-2414	54	25	the	the	DET
admet-2414	54	26	rate	rate	NOUN
admet-2414	54	27	of	of	ADP
admet-2414	54	28	export	export	NOUN
admet-2414	54	29	is	be	AUX
admet-2414	54	30	very	very	ADV
admet-2414	54	31	slow	slow	ADJ
admet-2414	54	32	,	,	PUNCT
admet-2414	54	33	with	with	ADP
admet-2414	54	34	a	a	DET
admet-2414	54	35	time	time	NOUN
admet-2414	54	36	constant	constant	ADJ
admet-2414	54	37	of	of	ADP
admet-2414	54	38	about	about	ADV
admet-2414	54	39	9.8	9.8	NUM
admet-2414	54	40	hours	hour	NOUN
admet-2414	54	41	(	(	PUNCT
admet-2414	54	42	k5	k5	PROPN
admet-2414	54	43	=	=	PROPN
admet-2414	54	44	0.0017	0.0017	NUM
admet-2414	54	45	min-1	min-1	NUM
admet-2414	54	46	)	)	PUNCT
admet-2414	54	47	.	.	PUNCT
admet-2414	55	1	this	this	DET
admet-2414	55	2	dramatic	dramatic	ADJ
admet-2414	55	3	difference	difference	NOUN
admet-2414	55	4	in	in	ADP
admet-2414	55	5	the	the	DET
admet-2414	55	6	rate	rate	NOUN
admet-2414	55	7	of	of	ADP
admet-2414	55	8	import	import	NOUN
admet-2414	55	9	and	and	CCONJ
admet-2414	55	10	export	export	NOUN
admet-2414	55	11	is	be	AUX
admet-2414	55	12	a	a	DET
admet-2414	55	13	characteristic	characteristic	NOUN
admet-2414	55	14	of	of	ADP
admet-2414	55	15	gr	gr	DET
admet-2414	55	16	kinetics	kinetic	NOUN
admet-2414	55	17	and	and	CCONJ
admet-2414	55	18	plays	play	VERB
admet-2414	55	19	a	a	DET
admet-2414	55	20	critical	critical	ADJ
admet-2414	55	21	role	role	NOUN
admet-2414	55	22	in	in	ADP
admet-2414	55	23	determining	determine	VERB
admet-2414	55	24	the	the	DET
admet-2414	55	25	g	g	PROPN
admet-2414	55	26	concentration	concentration	NOUN
admet-2414	55	27	dependence	dependence	NOUN
admet-2414	55	28	of	of	ADP
admet-2414	55	29	transcriptional	transcriptional	ADJ
admet-2414	55	30	modulation	modulation	NOUN
admet-2414	55	31	.	.	PUNCT
admet-2414	56	1	table	table	NOUN
admet-2414	56	2	1	1	NUM
admet-2414	56	3	.	.	PUNCT
admet-2414	56	4	model	model	NOUN
admet-2414	56	5	parameters	parameter	NOUN
admet-2414	56	6	for	for	ADP
admet-2414	56	7	dexamethasone	dexamethasone	NOUN
admet-2414	56	8	and	and	CCONJ
admet-2414	56	9	cortisol	cortisol	ADJ
admet-2414	56	10	parameter	parameter	NOUN
admet-2414	56	11	dexamethasone	dexamethasone	NOUN
admet-2414	56	12	cortisol	cortisol	NOUN
admet-2414	56	13	rtot	rtot	VERB
admet-2414	56	14	1	1	NUM
admet-2414	56	15	1	1	NUM
admet-2414	56	16	kc	kc	PROPN
admet-2414	56	17	/	/	SYM
admet-2414	56	18	nm	nm	NOUN
admet-2414	56	19	5	5	NUM
admet-2414	56	20	75	75	NUM
admet-2414	56	21	kn	kn	PROPN
admet-2414	56	22	/	/	PUNCT
admet-2414	56	23	nm	nm	PROPN
admet-2414	56	24	155	155	NUM
admet-2414	56	25	1550	1550	NUM
admet-2414	56	26	k1	k1	PROPN
admet-2414	56	27	/	/	SYM
admet-2414	56	28	min-1	min-1	PROPN
admet-2414	56	29	10	10	NUM
admet-2414	56	30	10	10	NUM
admet-2414	56	31	k2	k2	PROPN
admet-2414	56	32	/	/	SYM
admet-2414	56	33	min-1	min-1	PROPN
admet-2414	56	34	0.2	0.2	NUM
admet-2414	56	35	0.2	0.2	NUM
admet-2414	56	36	k3	k3	ADJ
admet-2414	56	37	/	/	SYM
admet-2414	56	38	min-1	min-1	NUM
admet-2414	56	39	0.2	0.2	NUM
admet-2414	56	40	0.2	0.2	NUM
admet-2414	56	41	k4	k4	NOUN
admet-2414	56	42	/	/	SYM
admet-2414	56	43	min-1	min-1	NUM
admet-2414	56	44	0.04	0.04	NUM
admet-2414	56	45	0.04	0.04	NUM
admet-2414	56	46	k5	k5	PROPN
admet-2414	56	47	/	/	SYM
admet-2414	56	48	min-1	min-1	PROPN
admet-2414	56	49	0.0017	0.0017	NUM
admet-2414	56	50	0.0017	0.0017	NUM
admet-2414	56	51	k6	k6	NOUN
admet-2414	56	52	/	/	SYM
admet-2414	56	53	min-1	min-1	PROPN
admet-2414	56	54	1.0	1.0	NUM
admet-2414	56	55	1.0	1.0	NUM
admet-2414	56	56	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	56	57	d.	d.	PROPN
admet-2414	56	58	g.	g.	PROPN
admet-2414	56	59	levitt	levitt	PROPN
admet-2414	56	60	admet	admet	PROPN
admet-2414	56	61	&	&	CCONJ
admet-2414	56	62	dmpk	dmpk	PROPN
admet-2414	56	63	12(6	12(6	NUM
admet-2414	56	64	)	)	PUNCT
admet-2414	56	65	(	(	PUNCT
admet-2414	56	66	2024	2024	NUM
admet-2414	56	67	)	)	PUNCT
admet-2414	56	68	971	971	NUM
admet-2414	56	69	-	-	SYM
admet-2414	56	70	989	989	NUM
admet-2414	56	71	974	974	NUM
admet-2414	56	72	although	although	SCONJ
admet-2414	56	73	the	the	DET
admet-2414	56	74	rates	rate	NOUN
admet-2414	56	75	of	of	ADP
admet-2414	56	76	conversion	conversion	NOUN
admet-2414	56	77	of	of	ADP
admet-2414	56	78	the	the	PRON
admet-2414	56	79	loosely	loosely	ADV
admet-2414	56	80	bound	bind	VERB
admet-2414	56	81	to	to	ADP
admet-2414	56	82	the	the	DET
admet-2414	56	83	tight	tight	ADJ
admet-2414	56	84	cytoplasmic	cytoplasmic	ADJ
admet-2414	56	85	form	form	NOUN
admet-2414	56	86	(	(	PUNCT
admet-2414	56	87	k1	k1	NOUN
admet-2414	56	88	)	)	PUNCT
admet-2414	56	89	has	have	AUX
admet-2414	56	90	not	not	PART
admet-2414	56	91	been	be	AUX
admet-2414	56	92	experimentally	experimentally	ADV
admet-2414	56	93	measured	measure	VERB
admet-2414	56	94	,	,	PUNCT
admet-2414	56	95	one	one	PRON
admet-2414	56	96	would	would	AUX
admet-2414	56	97	expect	expect	VERB
admet-2414	56	98	it	it	PRON
admet-2414	56	99	to	to	PART
admet-2414	56	100	be	be	AUX
admet-2414	56	101	fast	fast	ADV
admet-2414	56	102	relative	relative	ADJ
admet-2414	56	103	to	to	ADP
admet-2414	56	104	the	the	DET
admet-2414	56	105	nuclear	nuclear	ADJ
admet-2414	56	106	import	import	NOUN
admet-2414	56	107	rate	rate	NOUN
admet-2414	56	108	(	(	PUNCT
admet-2414	56	109	k2	k2	NOUN
admet-2414	56	110	)	)	PUNCT
admet-2414	56	111	that	that	SCONJ
admet-2414	56	112	it	it	PRON
admet-2414	56	113	is	be	AUX
admet-2414	56	114	in	in	ADP
admet-2414	56	115	series	series	NOUN
admet-2414	56	116	with	with	ADP
admet-2414	56	117	and	and	CCONJ
admet-2414	56	118	,	,	PUNCT
admet-2414	56	119	therefore	therefore	ADV
admet-2414	56	120	,	,	PUNCT
admet-2414	56	121	not	not	PART
admet-2414	56	122	rate	rate	VERB
admet-2414	56	123	limiting	limiting	NOUN
admet-2414	56	124	.	.	PUNCT
admet-2414	57	1	a	a	DET
admet-2414	57	2	time	time	NOUN
admet-2414	57	3	constant	constant	ADJ
admet-2414	57	4	of	of	ADP
admet-2414	57	5	0.1	0.1	NUM
admet-2414	57	6	min	min	NOUN
admet-2414	57	7	(	(	PUNCT
admet-2414	57	8	k1	k1	NOUN
admet-2414	57	9	=	=	SYM
admet-2414	57	10	10	10	NUM
admet-2414	57	11	min-1	min-1	NOUN
admet-2414	57	12	)	)	PUNCT
admet-2414	57	13	has	have	AUX
admet-2414	57	14	been	be	AUX
admet-2414	57	15	assumed	assume	VERB
admet-2414	57	16	.	.	PUNCT
admet-2414	58	1	as	as	SCONJ
admet-2414	58	2	shown	show	VERB
admet-2414	58	3	below	below	ADV
admet-2414	58	4	,	,	PUNCT
admet-2414	58	5	k1	k1	PROPN
admet-2414	58	6	is	be	AUX
admet-2414	58	7	the	the	DET
admet-2414	58	8	most	most	ADV
admet-2414	58	9	important	important	ADJ
admet-2414	58	10	parameter	parameter	NOUN
admet-2414	58	11	in	in	ADP
admet-2414	58	12	determining	determine	VERB
admet-2414	58	13	the	the	DET
admet-2414	58	14	apparent	apparent	ADJ
admet-2414	58	15	affinity	affinity	NOUN
admet-2414	58	16	of	of	ADP
admet-2414	58	17	the	the	DET
admet-2414	58	18	system	system	NOUN
admet-2414	58	19	at	at	ADP
admet-2414	58	20	very	very	ADV
admet-2414	58	21	low	low	ADJ
admet-2414	58	22	concentrations	concentration	NOUN
admet-2414	58	23	.	.	PUNCT
admet-2414	59	1	although	although	SCONJ
admet-2414	59	2	the	the	DET
admet-2414	59	3	diagram	diagram	NOUN
admet-2414	59	4	in	in	ADP
admet-2414	59	5	figure	figure	NOUN
admet-2414	59	6	1	1	NUM
admet-2414	59	7	suggests	suggest	VERB
admet-2414	59	8	that	that	SCONJ
admet-2414	59	9	k6	k6	NOUN
admet-2414	59	10	and	and	CCONJ
admet-2414	59	11	k1	k1	NOUN
admet-2414	59	12	should	should	AUX
admet-2414	59	13	have	have	VERB
admet-2414	59	14	a	a	DET
admet-2414	59	15	similar	similar	ADJ
admet-2414	59	16	rate	rate	NOUN
admet-2414	59	17	,	,	PUNCT
admet-2414	59	18	this	this	PRON
admet-2414	59	19	is	be	AUX
admet-2414	59	20	misleading	misleading	ADJ
admet-2414	59	21	,	,	PUNCT
admet-2414	59	22	and	and	CCONJ
admet-2414	59	23	k6	k6	NOUN
admet-2414	59	24	will	will	AUX
admet-2414	59	25	be	be	AUX
admet-2414	59	26	slower	slow	ADJ
admet-2414	59	27	than	than	ADP
admet-2414	59	28	k1	k1	NOUN
admet-2414	59	29	.	.	PUNCT
admet-2414	60	1	this	this	PRON
admet-2414	60	2	is	be	AUX
admet-2414	60	3	because	because	SCONJ
admet-2414	60	4	the	the	DET
admet-2414	60	5	process	process	NOUN
admet-2414	60	6	involved	involve	VERB
admet-2414	60	7	in	in	ADP
admet-2414	60	8	nuclear	nuclear	ADJ
admet-2414	60	9	import	import	NOUN
admet-2414	60	10	(=	(=	SYM
admet-2414	60	11	k2	k2	ADJ
admet-2414	60	12	)	)	PUNCT
admet-2414	60	13	involves	involve	VERB
admet-2414	60	14	a	a	DET
admet-2414	60	15	number	number	NOUN
admet-2414	60	16	of	of	ADP
admet-2414	60	17	cofactor	cofactor	NOUN
admet-2414	60	18	additions	addition	NOUN
admet-2414	60	19	necessary	necessary	ADJ
admet-2414	60	20	to	to	PART
admet-2414	60	21	convert	convert	VERB
admet-2414	60	22	rcgt	rcgt	PROPN
admet-2414	60	23	to	to	ADP
admet-2414	60	24	the	the	DET
admet-2414	60	25	rngt	rngt	PROPN
admet-2414	60	26	state	state	NOUN
admet-2414	60	27	,	,	PUNCT
admet-2414	60	28	and	and	CCONJ
admet-2414	60	29	these	these	DET
admet-2414	60	30	steps	step	NOUN
admet-2414	60	31	must	must	AUX
admet-2414	60	32	also	also	ADV
admet-2414	60	33	be	be	AUX
admet-2414	60	34	involved	involve	VERB
admet-2414	60	35	in	in	ADP
admet-2414	60	36	k6	k6	PROPN
admet-2414	60	37	,	,	PUNCT
admet-2414	60	38	which	which	PRON
admet-2414	60	39	has	have	AUX
admet-2414	60	40	been	be	AUX
admet-2414	60	41	assumed	assume	VERB
admet-2414	60	42	to	to	PART
admet-2414	60	43	have	have	VERB
admet-2414	60	44	a	a	DET
admet-2414	60	45	value	value	NOUN
admet-2414	60	46	of	of	ADP
admet-2414	60	47	1	1	NUM
admet-2414	60	48	min-1	min-1	NOUN
admet-2414	60	49	.	.	PUNCT
admet-2414	61	1	these	these	DET
admet-2414	61	2	estimates	estimate	NOUN
admet-2414	61	3	of	of	ADP
admet-2414	61	4	k1	k1	NOUN
admet-2414	61	5	and	and	CCONJ
admet-2414	61	6	k6	k6	NOUN
admet-2414	61	7	are	be	AUX
admet-2414	61	8	only	only	ADV
admet-2414	61	9	rough	rough	ADJ
admet-2414	61	10	guesses	guess	NOUN
admet-2414	61	11	.	.	PUNCT
admet-2414	62	1	another	another	DET
admet-2414	62	2	parameter	parameter	NOUN
admet-2414	62	3	that	that	PRON
admet-2414	62	4	can	can	AUX
admet-2414	62	5	be	be	AUX
admet-2414	62	6	directly	directly	ADV
admet-2414	62	7	measured	measure	VERB
admet-2414	62	8	,	,	PUNCT
admet-2414	62	9	although	although	SCONJ
admet-2414	62	10	under	under	ADP
admet-2414	62	11	limiting	limit	VERB
admet-2414	62	12	conditions	condition	NOUN
admet-2414	62	13	,	,	PUNCT
admet-2414	62	14	is	be	AUX
admet-2414	62	15	kc	kc	PROPN
admet-2414	62	16	.	.	PUNCT
admet-2414	63	1	in	in	ADP
admet-2414	63	2	the	the	DET
admet-2414	63	3	absence	absence	NOUN
admet-2414	63	4	of	of	ADP
admet-2414	63	5	glucocorticoid	glucocorticoid	NOUN
admet-2414	63	6	,	,	PUNCT
admet-2414	63	7	all	all	DET
admet-2414	63	8	receptors	receptor	NOUN
admet-2414	63	9	are	be	AUX
admet-2414	63	10	in	in	ADP
admet-2414	63	11	the	the	DET
admet-2414	63	12	cytoplasmic	cytoplasmic	ADJ
admet-2414	63	13	state	state	PROPN
admet-2414	63	14	rc	rc	PROPN
admet-2414	63	15	.	.	PUNCT
admet-2414	64	1	because	because	SCONJ
admet-2414	64	2	the	the	DET
admet-2414	64	3	conversion	conversion	NOUN
admet-2414	64	4	to	to	ADP
admet-2414	64	5	the	the	DET
admet-2414	64	6	tight	tight	ADJ
admet-2414	64	7	form	form	NOUN
admet-2414	64	8	rcgt	rcgt	PROPN
admet-2414	64	9	is	be	AUX
admet-2414	64	10	an	an	DET
admet-2414	64	11	active	active	ADJ
admet-2414	64	12	atp	atp	NOUN
admet-2414	64	13	-	-	PUNCT
admet-2414	64	14	driven	drive	VERB
admet-2414	64	15	process	process	NOUN
admet-2414	64	16	,	,	PUNCT
admet-2414	64	17	k1	k1	NOUN
admet-2414	64	18	=	=	SYM
admet-2414	64	19	0	0	NUM
admet-2414	64	20	for	for	ADP
admet-2414	64	21	measurements	measurement	NOUN
admet-2414	64	22	at	at	ADP
admet-2414	64	23	0	0	NUM
admet-2414	64	24	°	°	ADP
admet-2414	64	25	c	c	NOUN
admet-2414	64	26	,	,	PUNCT
admet-2414	64	27	and	and	CCONJ
admet-2414	64	28	gr	gr	NUM
admet-2414	64	29	binding	bind	VERB
admet-2414	64	30	measurements	measurement	NOUN
admet-2414	64	31	should	should	AUX
admet-2414	64	32	directly	directly	ADV
admet-2414	64	33	measure	measure	VERB
admet-2414	64	34	kc	kc	PROPN
admet-2414	64	35	.	.	PUNCT
admet-2414	65	1	the	the	DET
admet-2414	65	2	dexamethasone	dexamethasone	NOUN
admet-2414	65	3	(	(	PUNCT
admet-2414	65	4	dex	dex	NOUN
admet-2414	65	5	)	)	PUNCT
admet-2414	65	6	affinity	affinity	NOUN
admet-2414	65	7	(	(	PUNCT
admet-2414	65	8	≈	≈	PROPN
admet-2414	65	9	kc	kc	PROPN
admet-2414	65	10	)	)	PUNCT
admet-2414	65	11	of	of	ADP
admet-2414	65	12	homogenized	homogenized	ADJ
admet-2414	65	13	cells	cell	NOUN
admet-2414	65	14	at	at	ADP
admet-2414	65	15	0	0	NUM
admet-2414	65	16	°	°	ADP
admet-2414	65	17	c	c	NOUN
admet-2414	65	18	is	be	AUX
admet-2414	65	19	about	about	ADV
admet-2414	65	20	1	1	NUM
admet-2414	65	21	nm	nm	NOUN
admet-2414	65	22	[	[	X
admet-2414	65	23	25,26	25,26	NUM
admet-2414	65	24	]	]	X
admet-2414	65	25	.	.	PUNCT
admet-2414	66	1	the	the	DET
admet-2414	66	2	extrapolation	extrapolation	NOUN
admet-2414	66	3	of	of	ADP
admet-2414	66	4	this	this	DET
admet-2414	66	5	result	result	NOUN
admet-2414	66	6	to	to	ADP
admet-2414	66	7	37	37	NUM
admet-2414	66	8	°	°	NOUN
admet-2414	66	9	c	c	NOUN
admet-2414	66	10	is	be	AUX
admet-2414	66	11	uncertain	uncertain	ADJ
admet-2414	66	12	,	,	PUNCT
admet-2414	66	13	and	and	CCONJ
admet-2414	66	14	a	a	DET
admet-2414	66	15	value	value	NOUN
admet-2414	66	16	of	of	ADP
admet-2414	66	17	kc	kc	PROPN
admet-2414	66	18	=	=	SYM
admet-2414	66	19	5	5	NUM
admet-2414	66	20	nm	nm	NOUN
admet-2414	66	21	has	have	AUX
admet-2414	66	22	been	be	AUX
admet-2414	66	23	assumed	assume	VERB
admet-2414	66	24	.	.	PUNCT
admet-2414	67	1	as	as	SCONJ
admet-2414	67	2	discussed	discuss	VERB
admet-2414	67	3	below	below	ADV
admet-2414	67	4	,	,	PUNCT
admet-2414	67	5	the	the	DET
admet-2414	67	6	value	value	NOUN
admet-2414	67	7	of	of	ADP
admet-2414	67	8	kc	kc	PROPN
admet-2414	67	9	only	only	ADV
admet-2414	67	10	becomes	become	VERB
admet-2414	67	11	important	important	ADJ
admet-2414	67	12	for	for	ADP
admet-2414	67	13	gr	gr	X
admet-2414	67	14	transcriptional	transcriptional	ADJ
admet-2414	67	15	regulation	regulation	NOUN
admet-2414	67	16	at	at	ADP
admet-2414	67	17	very	very	ADV
admet-2414	67	18	low	low	ADJ
admet-2414	67	19	concentrations	concentration	NOUN
admet-2414	67	20	.	.	PUNCT
admet-2414	68	1	since	since	SCONJ
admet-2414	68	2	there	there	PRON
admet-2414	68	3	are	be	VERB
admet-2414	68	4	no	no	DET
admet-2414	68	5	accurate	accurate	ADJ
admet-2414	68	6	measurements	measurement	NOUN
admet-2414	68	7	in	in	ADP
admet-2414	68	8	this	this	DET
admet-2414	68	9	concentration	concentration	NOUN
admet-2414	68	10	range	range	NOUN
admet-2414	68	11	,	,	PUNCT
admet-2414	68	12	there	there	PRON
admet-2414	68	13	is	be	VERB
admet-2414	68	14	no	no	DET
admet-2414	68	15	direct	direct	ADJ
admet-2414	68	16	experimental	experimental	ADJ
admet-2414	68	17	evidence	evidence	NOUN
admet-2414	68	18	for	for	ADP
admet-2414	68	19	the	the	DET
admet-2414	68	20	value	value	NOUN
admet-2414	68	21	of	of	ADP
admet-2414	68	22	kc	kc	PROPN
admet-2414	68	23	at	at	ADP
admet-2414	68	24	37	37	NUM
admet-2414	68	25	°	°	NOUN
admet-2414	68	26	c	c	NOUN
admet-2414	68	27	.	.	PUNCT
admet-2414	69	1	the	the	DET
admet-2414	69	2	rate	rate	NOUN
admet-2414	69	3	that	that	PRON
admet-2414	69	4	the	the	DET
admet-2414	69	5	nuclear	nuclear	ADJ
admet-2414	69	6	form	form	NOUN
admet-2414	69	7	of	of	ADP
admet-2414	69	8	the	the	DET
admet-2414	69	9	receptor	receptor	NOUN
admet-2414	69	10	recycles	recycle	VERB
admet-2414	69	11	through	through	ADP
admet-2414	69	12	the	the	DET
admet-2414	69	13	unbound	unbound	NOUN
admet-2414	69	14	form	form	NOUN
admet-2414	69	15	and	and	CCONJ
admet-2414	69	16	back	back	ADV
admet-2414	69	17	to	to	ADP
admet-2414	69	18	the	the	DET
admet-2414	69	19	tightly	tightly	ADV
admet-2414	69	20	bound	bind	VERB
admet-2414	69	21	form	form	NOUN
admet-2414	69	22	without	without	ADP
admet-2414	69	23	leaving	leave	VERB
admet-2414	69	24	the	the	DET
admet-2414	69	25	nucleus	nucleus	NOUN
admet-2414	69	26	is	be	AUX
admet-2414	69	27	determined	determine	VERB
admet-2414	69	28	by	by	ADP
admet-2414	69	29	the	the	DET
admet-2414	69	30	rate	rate	NOUN
admet-2414	69	31	constants	constant	NOUN
admet-2414	69	32	k6	k6	PROPN
admet-2414	69	33	,	,	PUNCT
admet-2414	69	34	k3	k3	ADJ
admet-2414	69	35	and	and	CCONJ
admet-2414	69	36	k4	k4	ADJ
admet-2414	69	37	(	(	PUNCT
admet-2414	69	38	figure	figure	NOUN
admet-2414	69	39	1	1	NUM
admet-2414	69	40	)	)	PUNCT
admet-2414	69	41	.	.	PUNCT
admet-2414	70	1	these	these	DET
admet-2414	70	2	rates	rate	NOUN
admet-2414	70	3	can	can	AUX
admet-2414	70	4	be	be	AUX
admet-2414	70	5	estimated	estimate	VERB
admet-2414	70	6	from	from	ADP
admet-2414	70	7	the	the	DET
admet-2414	70	8	approximately	approximately	ADV
admet-2414	70	9	25	25	NUM
admet-2414	70	10	-	-	PUNCT
admet-2414	70	11	minute	minute	NOUN
admet-2414	70	12	half	half	ADJ
admet-2414	70	13	-	-	PUNCT
admet-2414	70	14	time	time	NOUN
admet-2414	70	15	of	of	ADP
admet-2414	70	16	the	the	DET
admet-2414	70	17	[	[	X
admet-2414	70	18	3h]dex	3h]dex	NUM
admet-2414	70	19	dissociation	dissociation	NOUN
admet-2414	70	20	rate	rate	NOUN
admet-2414	70	21	from	from	ADP
admet-2414	70	22	nuclear	nuclear	ADJ
admet-2414	70	23	receptors	receptor	NOUN
admet-2414	70	24	when	when	SCONJ
admet-2414	70	25	a	a	DET
admet-2414	70	26	200	200	NUM
admet-2414	70	27	-	-	ADJ
admet-2414	70	28	fold	fold	ADJ
admet-2414	70	29	excess	excess	NOUN
admet-2414	70	30	of	of	ADP
admet-2414	70	31	unlabeled	unlabeled	ADJ
admet-2414	70	32	dex	dex	NOUN
admet-2414	70	33	is	be	AUX
admet-2414	70	34	added	add	VERB
admet-2414	70	35	[	[	X
admet-2414	70	36	17,27	17,27	NUM
admet-2414	70	37	]	]	PUNCT
admet-2414	70	38	.	.	PUNCT
admet-2414	71	1	it	it	PRON
admet-2414	71	2	has	have	AUX
admet-2414	71	3	been	be	AUX
admet-2414	71	4	assumed	assume	VERB
admet-2414	71	5	that	that	SCONJ
admet-2414	71	6	the	the	DET
admet-2414	71	7	slowest	slow	ADJ
admet-2414	71	8	rate	rate	NOUN
admet-2414	71	9	in	in	ADP
admet-2414	71	10	this	this	DET
admet-2414	71	11	recycling	recycling	NOUN
admet-2414	71	12	is	be	AUX
admet-2414	71	13	k4	k4	NOUN
admet-2414	71	14	,	,	PUNCT
admet-2414	71	15	which	which	PRON
admet-2414	71	16	has	have	AUX
admet-2414	71	17	been	be	AUX
admet-2414	71	18	assigned	assign	VERB
admet-2414	71	19	a	a	DET
admet-2414	71	20	value	value	NOUN
admet-2414	71	21	of	of	ADP
admet-2414	71	22	k4	k4	NOUN
admet-2414	71	23	=	=	NOUN
admet-2414	71	24	0.04	0.04	NUM
admet-2414	71	25	min-1	min-1	NOUN
admet-2414	71	26	(	(	PUNCT
admet-2414	71	27	time	time	NOUN
admet-2414	71	28	constant	constant	ADJ
admet-2414	71	29	=	=	SYM
admet-2414	71	30	25	25	NUM
admet-2414	71	31	min	min	NOUN
admet-2414	71	32	)	)	PUNCT
admet-2414	71	33	and	and	CCONJ
admet-2414	71	34	that	that	SCONJ
admet-2414	71	35	k3	k3	VERB
admet-2414	71	36	=	=	PROPN
admet-2414	71	37	k2	k2	NOUN
admet-2414	71	38	=	=	PROPN
admet-2414	71	39	0.2	0.2	NUM
admet-2414	71	40	min-1	min-1	NOUN
admet-2414	71	41	.	.	PUNCT
admet-2414	72	1	the	the	DET
admet-2414	72	2	most	most	ADV
admet-2414	72	3	important	important	ADJ
admet-2414	72	4	experimental	experimental	ADJ
admet-2414	72	5	gr	gr	ADV
admet-2414	72	6	-	-	PUNCT
admet-2414	72	7	related	relate	VERB
admet-2414	72	8	measurement	measurement	NOUN
admet-2414	72	9	is	be	AUX
admet-2414	72	10	the	the	DET
admet-2414	72	11	steady	steady	ADJ
admet-2414	72	12	state	state	NOUN
admet-2414	72	13	g	g	PROPN
admet-2414	72	14	concentration	concentration	NOUN
admet-2414	72	15	dependence	dependence	NOUN
admet-2414	72	16	of	of	ADP
admet-2414	72	17	the	the	DET
admet-2414	72	18	transcriptional	transcriptional	ADJ
admet-2414	72	19	rate	rate	NOUN
admet-2414	72	20	.	.	PUNCT
admet-2414	73	1	recently	recently	ADV
admet-2414	73	2	,	,	PUNCT
admet-2414	73	3	detailed	detailed	ADJ
admet-2414	73	4	results	result	NOUN
admet-2414	73	5	for	for	ADP
admet-2414	73	6	a	a	DET
admet-2414	73	7	variety	variety	NOUN
admet-2414	73	8	of	of	ADP
admet-2414	73	9	glucocorticoids	glucocorticoid	NOUN
admet-2414	73	10	have	have	AUX
admet-2414	73	11	been	be	AUX
admet-2414	73	12	obtained	obtain	VERB
admet-2414	73	13	based	base	VERB
admet-2414	73	14	on	on	ADP
admet-2414	73	15	measurements	measurement	NOUN
admet-2414	73	16	of	of	ADP
admet-2414	73	17	gr	gr	NOUN
admet-2414	73	18	-	-	PUNCT
admet-2414	73	19	mediated	mediate	VERB
admet-2414	73	20	activation	activation	NOUN
admet-2414	73	21	of	of	ADP
admet-2414	73	22	a	a	DET
admet-2414	73	23	transfected	transfecte	VERB
admet-2414	73	24	reporter	reporter	NOUN
admet-2414	73	25	gene	gene	NOUN
admet-2414	73	26	in	in	ADP
admet-2414	73	27	a	a	DET
admet-2414	73	28	well	well	ADV
admet-2414	73	29	-	-	PUNCT
admet-2414	73	30	defined	define	VERB
admet-2414	73	31	cell	cell	NOUN
admet-2414	73	32	line	line	NOUN
admet-2414	74	1	[	[	X
admet-2414	74	2	28	28	NUM
admet-2414	74	3	-	-	SYM
admet-2414	74	4	32	32	NUM
admet-2414	74	5	]	]	PUNCT
admet-2414	74	6	.	.	PUNCT
admet-2414	75	1	the	the	DET
admet-2414	75	2	experimental	experimental	ADJ
admet-2414	75	3	concentration	concentration	NOUN
admet-2414	75	4	dependence	dependence	NOUN
admet-2414	75	5	is	be	AUX
admet-2414	75	6	usually	usually	ADV
admet-2414	75	7	well	well	ADV
admet-2414	75	8	described	describe	VERB
admet-2414	75	9	by	by	ADP
admet-2414	75	10	the	the	DET
admet-2414	75	11	standard	standard	NOUN
admet-2414	75	12	,	,	PUNCT
admet-2414	75	13	simple	simple	ADJ
admet-2414	75	14	michaelis	michaeli	NOUN
admet-2414	75	15	-	-	PUNCT
admet-2414	75	16	menten	menten	VERB
admet-2414	75	17	relation	relation	NOUN
admet-2414	75	18	equation	equation	NOUN
admet-2414	75	19	(	(	PUNCT
admet-2414	75	20	1	1	X
admet-2414	75	21	)	)	PUNCT
admet-2414	75	22	where	where	SCONJ
admet-2414	75	23	vmaxt	vmaxt	NOUN
admet-2414	75	24	and	and	CCONJ
admet-2414	75	25	kmt	kmt	PROPN
admet-2414	75	26	indicate	indicate	VERB
admet-2414	75	27	the	the	DET
admet-2414	75	28	vmax	vmax	PROPN
admet-2414	75	29	and	and	CCONJ
admet-2414	75	30	km	km	PROPN
admet-2414	75	31	experimental	experimental	ADJ
admet-2414	75	32	constants	constant	NOUN
admet-2414	75	33	determined	determine	VERB
admet-2414	75	34	from	from	ADP
admet-2414	75	35	transcriptional	transcriptional	ADJ
admet-2414	75	36	activation	activation	NOUN
admet-2414	75	37	measurements	measurement	NOUN
admet-2414	75	38	:	:	PUNCT
admet-2414	75	39	maxt	maxt	PROPN
admet-2414	75	40	[	[	PUNCT
admet-2414	75	41	]	]	PUNCT
admet-2414	75	42	transcription	transcription	NOUN
admet-2414	75	43	rate	rate	NOUN
admet-2414	75	44	mt	mt	PROPN
admet-2414	76	1	[	[	X
admet-2414	76	2	]	]	X
admet-2414	76	3	v	v	ADP
admet-2414	76	4	g	g	X
admet-2414	76	5	k	k	PROPN
admet-2414	76	6	g	g	PROPN
admet-2414	76	7	=	=	PUNCT
admet-2414	77	1	+	+	CCONJ
admet-2414	77	2	(	(	PUNCT
admet-2414	77	3	1	1	NUM
admet-2414	77	4	)	)	PUNCT
admet-2414	78	1	where	where	SCONJ
admet-2414	78	2	[	[	X
admet-2414	78	3	g	g	X
admet-2414	78	4	]	]	X
admet-2414	78	5	is	be	AUX
admet-2414	78	6	the	the	DET
admet-2414	78	7	free	free	ADJ
admet-2414	78	8	plasma	plasma	NOUN
admet-2414	78	9	glucocorticoid	glucocorticoid	ADJ
admet-2414	78	10	concentration	concentration	NOUN
admet-2414	78	11	.	.	PUNCT
admet-2414	79	1	the	the	DET
admet-2414	79	2	gr	gr	PROPN
admet-2414	79	3	concentration	concentration	NOUN
admet-2414	79	4	dependence	dependence	NOUN
admet-2414	79	5	is	be	AUX
admet-2414	79	6	characterized	characterize	VERB
admet-2414	79	7	by	by	ADP
admet-2414	79	8	the	the	DET
admet-2414	79	9	parameter	parameter	PROPN
admet-2414	79	10	kmt	kmt	PROPN
admet-2414	79	11	,	,	PUNCT
admet-2414	79	12	which	which	PRON
admet-2414	79	13	is	be	AUX
admet-2414	79	14	equal	equal	ADJ
admet-2414	79	15	to	to	ADP
admet-2414	79	16	the	the	DET
admet-2414	79	17	commonly	commonly	ADV
admet-2414	79	18	measured	measure	VERB
admet-2414	79	19	ec50	ec50	PROPN
admet-2414	79	20	(	(	PUNCT
admet-2414	79	21	or	or	CCONJ
admet-2414	79	22	,	,	PUNCT
admet-2414	79	23	for	for	ADP
admet-2414	79	24	the	the	DET
admet-2414	79	25	case	case	NOUN
admet-2414	79	26	where	where	SCONJ
admet-2414	79	27	g	g	PROPN
admet-2414	79	28	inhibits	inhibit	VERB
admet-2414	79	29	transcription	transcription	NOUN
admet-2414	79	30	,	,	PUNCT
admet-2414	79	31	ic50	ic50	PROPN
admet-2414	79	32	)	)	PUNCT
admet-2414	79	33	.	.	PUNCT
admet-2414	80	1	the	the	DET
admet-2414	80	2	kmt	kmt	PROPN
admet-2414	80	3	for	for	ADP
admet-2414	80	4	dex	dex	PROPN
admet-2414	80	5	varies	vary	VERB
admet-2414	80	6	for	for	ADP
admet-2414	80	7	different	different	ADJ
admet-2414	80	8	cell	cell	NOUN
admet-2414	80	9	lines	line	NOUN
admet-2414	80	10	,	,	PUNCT
admet-2414	80	11	ranging	range	VERB
admet-2414	80	12	from	from	ADP
admet-2414	80	13	1	1	NUM
admet-2414	80	14	to	to	PART
admet-2414	80	15	10	10	NUM
admet-2414	80	16	nm	nm	NOUN
admet-2414	80	17	[	[	X
admet-2414	80	18	28	28	NUM
admet-2414	80	19	-	-	SYM
admet-2414	80	20	32	32	NUM
admet-2414	80	21	]	]	PUNCT
admet-2414	80	22	,	,	PUNCT
admet-2414	80	23	and	and	CCONJ
admet-2414	80	24	a	a	DET
admet-2414	80	25	kmt	kmt	NOUN
admet-2414	80	26	of	of	ADP
admet-2414	80	27	5	5	NUM
admet-2414	80	28	nm	nm	NOUN
admet-2414	80	29	has	have	AUX
admet-2414	80	30	been	be	AUX
admet-2414	80	31	assumed	assume	VERB
admet-2414	80	32	.	.	PUNCT
admet-2414	81	1	results	result	NOUN
admet-2414	81	2	and	and	CCONJ
admet-2414	81	3	discussion	discussion	NOUN
admet-2414	81	4	steady	steady	ADJ
admet-2414	81	5	-	-	PUNCT
admet-2414	81	6	state	state	NOUN
admet-2414	81	7	glucocorticoid	glucocorticoid	ADJ
admet-2414	81	8	receptor	receptor	NOUN
admet-2414	81	9	model	model	NOUN
admet-2414	81	10	expressions	expression	NOUN
admet-2414	81	11	based	base	VERB
admet-2414	81	12	on	on	ADP
admet-2414	81	13	the	the	DET
admet-2414	81	14	model	model	NOUN
admet-2414	81	15	in	in	ADP
admet-2414	81	16	figure	figure	NOUN
admet-2414	81	17	1	1	NUM
admet-2414	81	18	,	,	PUNCT
admet-2414	81	19	it	it	PRON
admet-2414	81	20	will	will	AUX
admet-2414	81	21	be	be	AUX
admet-2414	81	22	assumed	assume	VERB
admet-2414	81	23	that	that	SCONJ
admet-2414	81	24	the	the	DET
admet-2414	81	25	transcriptional	transcriptional	ADJ
admet-2414	81	26	rate	rate	NOUN
admet-2414	81	27	is	be	AUX
admet-2414	81	28	proportional	proportional	ADJ
admet-2414	81	29	to	to	ADP
admet-2414	81	30	the	the	DET
admet-2414	81	31	fraction	fraction	NOUN
admet-2414	81	32	of	of	ADP
admet-2414	81	33	the	the	DET
admet-2414	81	34	gr	gr	NOUN
admet-2414	81	35	receptor	receptor	NOUN
admet-2414	81	36	that	that	PRON
admet-2414	81	37	is	be	AUX
admet-2414	81	38	in	in	ADP
admet-2414	81	39	the	the	DET
admet-2414	81	40	rngn	rngn	PROPN
admet-2414	81	41	state	state	NOUN
admet-2414	81	42	.	.	PUNCT
admet-2414	82	1	the	the	DET
admet-2414	82	2	steady	steady	ADJ
admet-2414	82	3	-	-	PUNCT
admet-2414	82	4	state	state	NOUN
admet-2414	82	5	expression	expression	NOUN
admet-2414	82	6	equation	equation	NOUN
admet-2414	82	7	(	(	PUNCT
admet-2414	82	8	2	2	NUM
admet-2414	82	9	)	)	PUNCT
admet-2414	82	10	for	for	ADP
admet-2414	82	11	the	the	DET
admet-2414	82	12	dependence	dependence	NOUN
admet-2414	82	13	of	of	ADP
admet-2414	82	14	rngn	rngn	NOUN
admet-2414	82	15	on	on	ADP
admet-2414	82	16	the	the	DET
admet-2414	82	17	glucocorticoid	glucocorticoid	ADJ
admet-2414	82	18	concentration	concentration	NOUN
admet-2414	82	19	g	g	NOUN
admet-2414	82	20	is	be	AUX
admet-2414	82	21	a	a	DET
admet-2414	82	22	complicated	complicated	ADJ
admet-2414	82	23	function	function	NOUN
admet-2414	82	24	of	of	ADP
admet-2414	82	25	all	all	DET
admet-2414	82	26	the	the	DET
admet-2414	82	27	model	model	NOUN
admet-2414	82	28	parameters	parameter	NOUN
admet-2414	82	29	(	(	PUNCT
admet-2414	82	30	see	see	VERB
admet-2414	82	31	supplement	supplement	NOUN
admet-2414	82	32	i	i	PRON
admet-2414	82	33	):	):	PUNCT
admet-2414	82	34	admet	admet	PROPN
admet-2414	82	35	&	&	CCONJ
admet-2414	82	36	dmpk	dmpk	PROPN
admet-2414	82	37	12(6	12(6	NUM
admet-2414	82	38	)	)	PUNCT
admet-2414	82	39	(	(	PUNCT
admet-2414	82	40	2024	2024	NUM
admet-2414	82	41	)	)	PUNCT
admet-2414	82	42	971	971	NUM
admet-2414	82	43	-	-	SYM
admet-2414	82	44	989	989	NUM
admet-2414	82	45	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	82	46	/	/	SYM
admet-2414	82	47	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	82	48	of	of	ADP
admet-2414	82	49	glucocorticoids	glucocorticoid	NOUN
admet-2414	82	50	doi	doi	NOUN
admet-2414	82	51	:	:	PUNCT
admet-2414	82	52	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	82	53	975	975	NUM
admet-2414	82	54	2	2	NUM
admet-2414	82	55	rngn	rngn	NOUN
admet-2414	82	56	(	(	PUNCT
admet-2414	82	57	6	6	NUM
admet-2414	82	58	[	[	PUNCT
admet-2414	82	59	]	]	X
admet-2414	82	60	n	n	PRON
admet-2414	82	61	5	5	NUM
admet-2414	82	62	)	)	PUNCT
admet-2414	82	63	3	3	NUM
admet-2414	82	64	2	2	NUM
admet-2414	82	65	1	1	NUM
admet-2414	82	66	[	[	PUNCT
admet-2414	82	67	]	]	X
admet-2414	82	68	(	(	PUNCT
admet-2414	82	69	(	(	PUNCT
admet-2414	82	70	4	4	NUM
admet-2414	82	71	6	6	NUM
admet-2414	82	72	)	)	PUNCT
admet-2414	82	73	3	3	NUM
admet-2414	82	74	4	4	NUM
admet-2414	82	75	6	6	NUM
admet-2414	82	76	)	)	PUNCT
admet-2414	82	77	1	1	NUM
admet-2414	82	78	2	2	NUM
admet-2414	82	79	[	[	PUNCT
admet-2414	82	80	]	]	X
admet-2414	82	81	n	n	CCONJ
admet-2414	82	82	[	[	PUNCT
admet-2414	82	83	]	]	X
admet-2414	82	84	(	(	PUNCT
admet-2414	82	85	(	(	PUNCT
admet-2414	82	86	(	(	PUNCT
admet-2414	82	87	(	(	PUNCT
admet-2414	82	88	4	4	NUM
admet-2414	82	89	5	5	NUM
admet-2414	82	90	)	)	PUNCT
admet-2414	82	91	3	3	NUM
admet-2414	82	92	4	4	NUM
admet-2414	82	93	5	5	NUM
admet-2414	82	94	)	)	PUNCT
admet-2414	82	95	1	1	NUM
admet-2414	82	96	3	3	NUM
admet-2414	82	97	4	4	NUM
admet-2414	82	98	5	5	NUM
admet-2414	82	99	)	)	PUNCT
admet-2414	82	100	2	2	NUM
admet-2414	82	101	1	1	NUM
admet-2414	82	102	3	3	NUM
admet-2414	82	103	4	4	NUM
admet-2414	82	104	5	5	NUM
admet-2414	82	105	)	)	PUNCT
admet-2414	82	106	5	5	NUM
admet-2414	82	107	2	2	NUM
admet-2414	82	108	3	3	NUM
admet-2414	82	109	4	4	NUM
admet-2414	82	110	a	a	DET
admet-2414	82	111	f	f	NOUN
admet-2414	82	112	b	b	PROPN
admet-2414	82	113	c	c	PROPN
admet-2414	82	114	a	a	PRON
admet-2414	82	115	k	k	NOUN
admet-2414	82	116	g	g	PROPN
admet-2414	83	1	k	k	PROPN
admet-2414	83	2	k	k	PROPN
admet-2414	84	1	k	k	PROPN
admet-2414	84	2	k	k	PROPN
admet-2414	85	1	k	k	PROPN
admet-2414	85	2	g	g	PROPN
admet-2414	85	3	b	b	PROPN
admet-2414	86	1	k	k	PROPN
admet-2414	86	2	k	k	PROPN
admet-2414	87	1	k	k	PROPN
admet-2414	87	2	k	k	PROPN
admet-2414	88	1	k	k	PROPN
admet-2414	88	2	k	k	PROPN
admet-2414	89	1	k	k	PROPN
admet-2414	89	2	g	g	PROPN
admet-2414	90	1	c	c	PROPN
admet-2414	90	2	k	k	PROPN
admet-2414	91	1	g	g	PROPN
admet-2414	91	2	k	k	PROPN
admet-2414	92	1	k	k	PROPN
admet-2414	92	2	k	k	PROPN
admet-2414	93	1	k	k	PROPN
admet-2414	93	2	k	k	PROPN
admet-2414	93	3	k	k	PROPN
admet-2414	93	4	k	k	PROPN
admet-2414	93	5	k	k	PROPN
admet-2414	93	6	k	k	PROPN
admet-2414	93	7	k	k	PROPN
admet-2414	93	8	k	k	PROPN
admet-2414	93	9	k	k	PROPN
admet-2414	93	10	k	k	PROPN
admet-2414	93	11	k	k	PROPN
admet-2414	93	12	knkc	knkc	PROPN
admet-2414	94	1	k	k	PROPN
admet-2414	94	2	k	k	PROPN
admet-2414	95	1	k	k	PROPN
admet-2414	95	2	k	k	PROPN
admet-2414	96	1	=	=	PUNCT
admet-2414	96	2	+	+	PUNCT
admet-2414	96	3	=	=	SYM
admet-2414	96	4	+	+	PUNCT
admet-2414	96	5	=	=	PUNCT
admet-2414	97	1	+	+	PUNCT
admet-2414	97	2	+	+	CCONJ
admet-2414	97	3	=	=	X
admet-2414	98	1	+	+	PUNCT
admet-2414	98	2	+	+	PUNCT
admet-2414	98	3	+	+	PUNCT
admet-2414	98	4	+	+	PUNCT
admet-2414	98	5	+	+	CCONJ
admet-2414	98	6	(	(	PUNCT
admet-2414	98	7	2	2	NUM
admet-2414	98	8	)	)	PUNCT
admet-2414	98	9	where	where	SCONJ
admet-2414	98	10	frngn	frngn	NOUN
admet-2414	98	11	is	be	AUX
admet-2414	98	12	the	the	DET
admet-2414	98	13	fraction	fraction	NOUN
admet-2414	98	14	of	of	ADP
admet-2414	98	15	the	the	DET
admet-2414	98	16	receptor	receptor	NOUN
admet-2414	98	17	that	that	PRON
admet-2414	98	18	is	be	AUX
admet-2414	98	19	in	in	ADP
admet-2414	98	20	the	the	DET
admet-2414	98	21	rngn	rngn	PROPN
admet-2414	98	22	state	state	NOUN
admet-2414	98	23	(=	(=	NOUN
admet-2414	98	24	rngn	rngn	NOUN
admet-2414	98	25	/	/	SYM
admet-2414	98	26	rtot	rtot	NOUN
admet-2414	98	27	)	)	PUNCT
admet-2414	98	28	.	.	PUNCT
admet-2414	99	1	as	as	SCONJ
admet-2414	99	2	discussed	discuss	VERB
admet-2414	99	3	above	above	ADV
admet-2414	99	4	,	,	PUNCT
admet-2414	99	5	a	a	DET
admet-2414	99	6	characteristic	characteristic	NOUN
admet-2414	99	7	of	of	ADP
admet-2414	99	8	gr	gr	DET
admet-2414	99	9	kinetics	kinetic	NOUN
admet-2414	99	10	is	be	AUX
admet-2414	99	11	the	the	DET
admet-2414	99	12	relatively	relatively	ADV
admet-2414	99	13	rapid	rapid	ADJ
admet-2414	99	14	rate	rate	NOUN
admet-2414	99	15	of	of	ADP
admet-2414	99	16	nuclear	nuclear	ADJ
admet-2414	99	17	import	import	NOUN
admet-2414	99	18	(	(	PUNCT
admet-2414	99	19	5	5	NUM
admet-2414	99	20	min	min	NOUN
admet-2414	99	21	)	)	PUNCT
admet-2414	99	22	versus	versus	ADP
admet-2414	99	23	an	an	DET
admet-2414	99	24	extremely	extremely	ADV
admet-2414	99	25	slow	slow	ADJ
admet-2414	99	26	rate	rate	NOUN
admet-2414	99	27	of	of	ADP
admet-2414	99	28	export	export	NOUN
admet-2414	99	29	(	(	PUNCT
admet-2414	99	30	10	10	NUM
admet-2414	99	31	hours	hour	NOUN
admet-2414	99	32	)	)	PUNCT
admet-2414	99	33	.	.	PUNCT
admet-2414	100	1	this	this	PRON
admet-2414	100	2	means	mean	VERB
admet-2414	100	3	that	that	SCONJ
admet-2414	100	4	,	,	PUNCT
admet-2414	100	5	except	except	SCONJ
admet-2414	100	6	at	at	ADP
admet-2414	100	7	very	very	ADV
admet-2414	100	8	low	low	ADJ
admet-2414	100	9	g	g	NOUN
admet-2414	100	10	concentrations	concentration	NOUN
admet-2414	100	11	,	,	PUNCT
admet-2414	100	12	the	the	DET
admet-2414	100	13	receptor	receptor	NOUN
admet-2414	100	14	is	be	AUX
admet-2414	100	15	almost	almost	ADV
admet-2414	100	16	entirely	entirely	ADV
admet-2414	100	17	nuclear	nuclear	ADJ
admet-2414	100	18	.	.	PUNCT
admet-2414	101	1	thus	thus	ADV
admet-2414	101	2	,	,	PUNCT
admet-2414	101	3	for	for	ADP
admet-2414	101	4	the	the	DET
admet-2414	101	5	range	range	NOUN
admet-2414	101	6	of	of	ADP
admet-2414	101	7	concentrations	concentration	NOUN
admet-2414	101	8	that	that	PRON
admet-2414	101	9	are	be	AUX
admet-2414	101	10	normally	normally	ADV
admet-2414	101	11	experimentally	experimentally	ADV
admet-2414	101	12	measured	measure	VERB
admet-2414	101	13	,	,	PUNCT
admet-2414	101	14	equation	equation	NOUN
admet-2414	101	15	(	(	PUNCT
admet-2414	101	16	2	2	X
admet-2414	101	17	)	)	PUNCT
admet-2414	101	18	can	can	AUX
admet-2414	101	19	be	be	AUX
admet-2414	101	20	simplified	simplify	VERB
admet-2414	101	21	by	by	ADP
admet-2414	101	22	assuming	assume	VERB
admet-2414	101	23	that	that	SCONJ
admet-2414	101	24	the	the	DET
admet-2414	101	25	receptor	receptor	NOUN
admet-2414	101	26	is	be	AUX
admet-2414	101	27	100	100	NUM
admet-2414	101	28	%	%	NOUN
admet-2414	101	29	nuclear	nuclear	ADJ
admet-2414	101	30	.	.	PUNCT
admet-2414	102	1	for	for	ADP
admet-2414	102	2	this	this	DET
admet-2414	102	3	case	case	NOUN
admet-2414	102	4	,	,	PUNCT
admet-2414	102	5	remarkably	remarkably	ADV
admet-2414	102	6	,	,	PUNCT
admet-2414	102	7	equation	equation	NOUN
admet-2414	102	8	(	(	PUNCT
admet-2414	102	9	2	2	X
admet-2414	102	10	)	)	PUNCT
admet-2414	102	11	reduces	reduce	VERB
admet-2414	102	12	to	to	ADP
admet-2414	102	13	the	the	DET
admet-2414	102	14	michaelis	michaeli	NOUN
admet-2414	102	15	-	-	PUNCT
admet-2414	102	16	menten	menten	ADJ
admet-2414	102	17	form	form	NOUN
admet-2414	102	18	equation	equation	NOUN
admet-2414	102	19	(	(	PUNCT
admet-2414	102	20	3	3	NUM
admet-2414	102	21	)	)	PUNCT
admet-2414	102	22	(	(	PUNCT
admet-2414	102	23	see	see	VERB
admet-2414	102	24	supplement	supplement	NOUN
admet-2414	102	25	i	i	PRON
admet-2414	102	26	)	)	PUNCT
admet-2414	102	27	where	where	SCONJ
admet-2414	102	28	vmaxh	vmaxh	NOUN
admet-2414	102	29	and	and	CCONJ
admet-2414	102	30	kmh	kmh	NOUN
admet-2414	102	31	are	be	AUX
admet-2414	102	32	the	the	DET
admet-2414	102	33	vmax	vmax	PROPN
admet-2414	102	34	and	and	CCONJ
admet-2414	102	35	km	km	PROPN
admet-2414	102	36	determined	determine	VERB
admet-2414	102	37	in	in	ADP
admet-2414	102	38	the	the	DET
admet-2414	102	39	high	high	ADJ
admet-2414	102	40	concentration	concentration	NOUN
admet-2414	102	41	limit	limit	NOUN
admet-2414	102	42	:	:	PUNCT
admet-2414	102	43	maxh	maxh	X
admet-2414	102	44	[	[	PUNCT
admet-2414	102	45	]	]	X
admet-2414	102	46	6	6	NUM
admet-2414	102	47	6	6	NUM
admet-2414	102	48	(	(	PUNCT
admet-2414	102	49	3	3	NUM
admet-2414	102	50	4)n	4)n	NUM
admet-2414	102	51	rngn	rngn	PROPN
admet-2414	102	52	mh	mh	PROPN
admet-2414	102	53	maxh	maxh	VERB
admet-2414	102	54	1	1	NUM
admet-2414	102	55	mh	mh	PROPN
admet-2414	102	56	[	[	PUNCT
admet-2414	102	57	]	]	X
admet-2414	102	58	4	4	NUM
admet-2414	102	59	3	3	NUM
admet-2414	102	60	4	4	NUM
admet-2414	102	61	v	v	NOUN
admet-2414	102	62	g	g	PROPN
admet-2414	103	1	k	k	PROPN
admet-2414	104	1	k	k	PROPN
admet-2414	105	1	k	k	PROPN
admet-2414	106	1	kk	kk	PROPN
admet-2414	107	1	f	f	PROPN
admet-2414	108	1	k	k	PROPN
admet-2414	109	1	v	v	INTJ
admet-2414	109	2	c	c	NOUN
admet-2414	110	1	k	k	NOUN
admet-2414	110	2	g	g	PROPN
admet-2414	111	1	c	c	PROPN
admet-2414	111	2	c	c	PROPN
admet-2414	112	1	k	k	PROPN
admet-2414	112	2	k	k	PROPN
admet-2414	112	3	k	k	PROPN
admet-2414	113	1	+	+	PUNCT
admet-2414	113	2	=	=	SYM
admet-2414	113	3	=	=	SYM
admet-2414	113	4	=	=	PUNCT
admet-2414	114	1	=	=	PUNCT
admet-2414	115	1	+	+	PUNCT
admet-2414	115	2	+	+	CCONJ
admet-2414	115	3	(	(	PUNCT
admet-2414	115	4	3	3	NUM
admet-2414	115	5	)	)	PUNCT
admet-2414	115	6	as	as	SCONJ
admet-2414	115	7	expected	expect	VERB
admet-2414	115	8	,	,	PUNCT
admet-2414	115	9	the	the	DET
admet-2414	115	10	kinetics	kinetic	NOUN
admet-2414	115	11	in	in	ADP
admet-2414	115	12	this	this	DET
admet-2414	115	13	limit	limit	NOUN
admet-2414	115	14	does	do	AUX
admet-2414	115	15	not	not	PART
admet-2414	115	16	depend	depend	VERB
admet-2414	115	17	on	on	ADP
admet-2414	115	18	any	any	PRON
admet-2414	115	19	of	of	ADP
admet-2414	115	20	the	the	DET
admet-2414	115	21	cytoplasmic	cytoplasmic	ADJ
admet-2414	115	22	model	model	NOUN
admet-2414	115	23	parameters	parameter	NOUN
admet-2414	115	24	(	(	PUNCT
admet-2414	115	25	kc	kc	PROPN
admet-2414	115	26	,	,	PUNCT
admet-2414	115	27	k1	k1	PROPN
admet-2414	115	28	,	,	PUNCT
admet-2414	115	29	k2	k2	PROPN
admet-2414	115	30	,	,	PUNCT
admet-2414	115	31	k5	k5	PROPN
admet-2414	115	32	)	)	PUNCT
admet-2414	115	33	.	.	PUNCT
admet-2414	116	1	assuming	assume	VERB
admet-2414	116	2	that	that	PRON
admet-2414	116	3	kmh	kmh	NOUN
admet-2414	116	4	for	for	ADP
admet-2414	116	5	dex	dex	NOUN
admet-2414	116	6	is	be	AUX
admet-2414	116	7	equal	equal	ADJ
admet-2414	116	8	to	to	ADP
admet-2414	116	9	the	the	DET
admet-2414	116	10	experimentally	experimentally	ADV
admet-2414	116	11	measured	measure	VERB
admet-2414	116	12	kmt	kmt	PROPN
admet-2414	116	13	(	(	PUNCT
admet-2414	116	14	equation	equation	NOUN
admet-2414	116	15	(	(	PUNCT
admet-2414	116	16	1	1	NUM
admet-2414	116	17	)	)	PUNCT
admet-2414	116	18	)	)	PUNCT
admet-2414	116	19	of	of	ADP
admet-2414	116	20	5	5	NUM
admet-2414	116	21	nm	nm	NOUN
admet-2414	116	22	,	,	PUNCT
admet-2414	116	23	and	and	CCONJ
admet-2414	116	24	using	use	VERB
admet-2414	116	25	the	the	DET
admet-2414	116	26	assumed	assumed	ADJ
admet-2414	116	27	values	value	NOUN
admet-2414	116	28	of	of	ADP
admet-2414	116	29	k6	k6	PROPN
admet-2414	116	30	,	,	PUNCT
admet-2414	116	31	k3	k3	X
admet-2414	116	32	,	,	PUNCT
admet-2414	116	33	and	and	CCONJ
admet-2414	116	34	k4	k4	NOUN
admet-2414	116	35	(	(	PUNCT
admet-2414	116	36	table	table	NOUN
admet-2414	116	37	1	1	NUM
admet-2414	116	38	)	)	PUNCT
admet-2414	116	39	in	in	ADP
admet-2414	116	40	equation	equation	NOUN
admet-2414	116	41	(	(	PUNCT
admet-2414	116	42	3	3	NUM
admet-2414	116	43	)	)	PUNCT
admet-2414	116	44	,	,	PUNCT
admet-2414	116	45	c	c	NOUN
admet-2414	116	46	=	=	SYM
admet-2414	116	47	31	31	NUM
admet-2414	116	48	,	,	PUNCT
admet-2414	116	49	vmaxh	vmaxh	NOUN
admet-2414	116	50	=	=	NOUN
admet-2414	116	51	0.769	0.769	NUM
admet-2414	116	52	,	,	PUNCT
admet-2414	116	53	and	and	CCONJ
admet-2414	116	54	kn	kn	PROPN
admet-2414	116	55	=	=	NOUN
admet-2414	116	56	155	155	NUM
admet-2414	116	57	nm	nm	NOUN
admet-2414	116	58	(	(	PUNCT
admet-2414	116	59	table	table	NOUN
admet-2414	116	60	1	1	NUM
admet-2414	116	61	)	)	PUNCT
admet-2414	116	62	.	.	PUNCT
admet-2414	117	1	this	this	DET
admet-2414	117	2	value	value	NOUN
admet-2414	117	3	of	of	ADP
admet-2414	117	4	kn	kn	PROPN
admet-2414	117	5	is	be	AUX
admet-2414	117	6	just	just	ADV
admet-2414	117	7	an	an	DET
admet-2414	117	8	estimate	estimate	NOUN
admet-2414	117	9	because	because	SCONJ
admet-2414	117	10	it	it	PRON
admet-2414	117	11	depends	depend	VERB
admet-2414	117	12	on	on	ADP
admet-2414	117	13	the	the	DET
admet-2414	117	14	assumed	assumed	ADJ
admet-2414	117	15	values	value	NOUN
admet-2414	117	16	of	of	ADP
admet-2414	117	17	k3	k3	PROPN
admet-2414	117	18	,	,	PUNCT
admet-2414	117	19	k4	k4	NOUN
admet-2414	117	20	and	and	CCONJ
admet-2414	117	21	k6	k6	NOUN
admet-2414	117	22	,	,	PUNCT
admet-2414	117	23	values	value	VERB
admet-2414	117	24	that	that	SCONJ
admet-2414	117	25	,	,	PUNCT
admet-2414	117	26	as	as	SCONJ
admet-2414	117	27	discussed	discuss	VERB
admet-2414	117	28	above	above	ADV
admet-2414	117	29	,	,	PUNCT
admet-2414	117	30	are	be	AUX
admet-2414	117	31	only	only	ADV
admet-2414	117	32	rough	rough	ADJ
admet-2414	117	33	guesses	guess	NOUN
admet-2414	117	34	.	.	PUNCT
admet-2414	118	1	there	there	PRON
admet-2414	118	2	are	be	VERB
admet-2414	118	3	no	no	DET
admet-2414	118	4	direct	direct	ADJ
admet-2414	118	5	experimental	experimental	ADJ
admet-2414	118	6	measurements	measurement	NOUN
admet-2414	118	7	of	of	ADP
admet-2414	118	8	kn	kn	PROPN
admet-2414	118	9	.	.	PUNCT
admet-2414	119	1	the	the	DET
admet-2414	119	2	kinetic	kinetic	ADJ
admet-2414	119	3	model	model	NOUN
admet-2414	119	4	(	(	PUNCT
admet-2414	119	5	figure	figure	NOUN
admet-2414	119	6	1	1	NUM
admet-2414	119	7	)	)	PUNCT
admet-2414	119	8	exhibits	exhibit	VERB
admet-2414	119	9	interesting	interesting	ADJ
admet-2414	119	10	behavior	behavior	NOUN
admet-2414	119	11	in	in	ADP
admet-2414	119	12	the	the	DET
admet-2414	119	13	very	very	ADV
admet-2414	119	14	low	low	ADJ
admet-2414	119	15	g	g	NOUN
admet-2414	119	16	concentration	concentration	NOUN
admet-2414	119	17	limit	limit	NOUN
admet-2414	119	18	where	where	SCONJ
admet-2414	119	19	the	the	DET
admet-2414	119	20	nuclear	nuclear	ADJ
admet-2414	119	21	equilibrium	equilibrium	NOUN
admet-2414	119	22	binding	bind	VERB
admet-2414	119	23	of	of	ADP
admet-2414	119	24	g	g	PROPN
admet-2414	119	25	to	to	ADP
admet-2414	119	26	rn	rn	PROPN
admet-2414	119	27	is	be	AUX
admet-2414	119	28	negligible	negligible	ADJ
admet-2414	119	29	and	and	CCONJ
admet-2414	119	30	there	there	PRON
admet-2414	119	31	is	be	VERB
admet-2414	119	32	no	no	DET
admet-2414	119	33	nuclear	nuclear	ADJ
admet-2414	119	34	recycling	recycling	NOUN
admet-2414	119	35	of	of	ADP
admet-2414	119	36	the	the	DET
admet-2414	119	37	receptor	receptor	NOUN
admet-2414	119	38	.	.	PUNCT
admet-2414	120	1	in	in	ADP
admet-2414	120	2	this	this	DET
admet-2414	120	3	limit	limit	NOUN
admet-2414	120	4	,	,	PUNCT
admet-2414	120	5	equation	equation	NOUN
admet-2414	120	6	(	(	PUNCT
admet-2414	120	7	2	2	X
admet-2414	120	8	)	)	PUNCT
admet-2414	120	9	again	again	ADV
admet-2414	120	10	reduces	reduce	VERB
admet-2414	120	11	to	to	ADP
admet-2414	120	12	a	a	DET
admet-2414	120	13	michaelis	michaelis	ADJ
admet-2414	120	14	-	-	PUNCT
admet-2414	120	15	menten	menten	ADJ
admet-2414	120	16	form	form	NOUN
admet-2414	120	17	equation	equation	NOUN
admet-2414	120	18	4	4	NUM
admet-2414	120	19	(	(	PUNCT
admet-2414	120	20	see	see	VERB
admet-2414	120	21	supplement	supplement	NOUN
admet-2414	120	22	i	i	PRON
admet-2414	120	23	)	)	PUNCT
admet-2414	120	24	where	where	SCONJ
admet-2414	120	25	vmaxl	vmaxl	NOUN
admet-2414	120	26	and	and	CCONJ
admet-2414	120	27	kml	kml	PROPN
admet-2414	120	28	are	be	AUX
admet-2414	120	29	the	the	DET
admet-2414	120	30	vmax	vmax	PROPN
admet-2414	120	31	and	and	CCONJ
admet-2414	120	32	km	km	PROPN
admet-2414	120	33	determined	determine	VERB
admet-2414	120	34	in	in	ADP
admet-2414	120	35	the	the	DET
admet-2414	120	36	low	low	ADJ
admet-2414	120	37	concentration	concentration	NOUN
admet-2414	120	38	limit	limit	NOUN
admet-2414	120	39	:	:	PUNCT
admet-2414	120	40	maxl	maxl	PROPN
admet-2414	120	41	[	[	PUNCT
admet-2414	120	42	]	]	X
admet-2414	120	43	4	4	NUM
admet-2414	120	44	c	c	NOUN
admet-2414	120	45	1	1	NUM
admet-2414	120	46	4	4	NUM
admet-2414	120	47	4	4	NUM
admet-2414	120	48	4	4	NUM
admet-2414	120	49	rngn	rngn	NOUN
admet-2414	120	50	ml	ml	AUX
admet-2414	120	51	maxl	maxl	VERB
admet-2414	120	52	1	1	NUM
admet-2414	120	53	ml	ml	NOUN
admet-2414	120	54	[	[	PUNCT
admet-2414	120	55	]	]	X
admet-2414	120	56	1	1	NUM
admet-2414	120	57	2	2	NUM
admet-2414	120	58	3	3	NUM
admet-2414	120	59	5	5	NUM
admet-2414	120	60	v	v	NOUN
admet-2414	120	61	g	g	PROPN
admet-2414	120	62	k	k	PROPN
admet-2414	121	1	k	k	PROPN
admet-2414	121	2	k	k	PROPN
admet-2414	122	1	k	k	PROPN
admet-2414	123	1	k	k	PROPN
admet-2414	123	2	f	f	PROPN
admet-2414	124	1	k	k	PROPN
admet-2414	124	2	v	v	PROPN
admet-2414	125	1	d	d	X
admet-2414	125	2	k	k	NOUN
admet-2414	126	1	g	g	NOUN
admet-2414	126	2	dk	dk	PROPN
admet-2414	127	1	d	d	X
admet-2414	127	2	k	k	PROPN
admet-2414	127	3	k	k	PROPN
admet-2414	127	4	k	k	PROPN
admet-2414	127	5	=	=	PUNCT
admet-2414	128	1	=	=	PUNCT
admet-2414	128	2	=	=	PUNCT
admet-2414	128	3	=	=	PUNCT
admet-2414	129	1	+	+	PUNCT
admet-2414	129	2	+	+	PUNCT
admet-2414	129	3	+	+	PUNCT
admet-2414	129	4	+	+	CCONJ
admet-2414	129	5	(	(	PUNCT
admet-2414	129	6	4	4	X
admet-2414	129	7	)	)	PUNCT
admet-2414	129	8	substituting	substitute	VERB
admet-2414	129	9	the	the	DET
admet-2414	129	10	assumed	assumed	ADJ
admet-2414	129	11	values	value	NOUN
admet-2414	129	12	of	of	ADP
admet-2414	129	13	k2	k2	NOUN
admet-2414	129	14	,	,	PUNCT
admet-2414	129	15	k3	k3	PROPN
admet-2414	129	16	,	,	PUNCT
admet-2414	129	17	k4	k4	PROPN
admet-2414	129	18	,	,	PUNCT
admet-2414	129	19	k5	k5	PROPN
admet-2414	129	20	and	and	CCONJ
admet-2414	129	21	kc	kc	PROPN
admet-2414	129	22	(	(	PUNCT
admet-2414	129	23	table	table	NOUN
admet-2414	129	24	1	1	NUM
admet-2414	129	25	)	)	PUNCT
admet-2414	129	26	in	in	ADP
admet-2414	129	27	equation	equation	NOUN
admet-2414	129	28	(	(	PUNCT
admet-2414	129	29	4	4	NUM
admet-2414	129	30	)	)	PUNCT
admet-2414	129	31	,	,	PUNCT
admet-2414	129	32	d	d	NOUN
admet-2414	129	33	=	=	SYM
admet-2414	129	34	31.5	31.5	NUM
admet-2414	129	35	,	,	PUNCT
admet-2414	129	36	vmaxl=	vmaxl=	NUM
admet-2414	130	1	0.0317	0.0317	NUM
admet-2414	130	2	and	and	CCONJ
admet-2414	130	3	kml	kml	PROPN
admet-2414	130	4	=	=	PROPN
admet-2414	130	5	0.000787	0.000787	NUM
admet-2414	130	6	nm	nm	NOUN
admet-2414	130	7	.	.	PUNCT
admet-2414	131	1	thus	thus	ADV
admet-2414	131	2	,	,	PUNCT
admet-2414	131	3	at	at	ADP
admet-2414	131	4	very	very	ADV
admet-2414	131	5	low	low	ADJ
admet-2414	131	6	concentrations	concentration	NOUN
admet-2414	131	7	(	(	PUNCT
admet-2414	131	8	less	less	ADJ
admet-2414	131	9	than	than	ADP
admet-2414	131	10	about	about	ADV
admet-2414	131	11	1	1	NUM
admet-2414	131	12	%	%	NOUN
admet-2414	131	13	of	of	ADP
admet-2414	131	14	kmt	kmt	PROPN
admet-2414	131	15	)	)	PUNCT
admet-2414	131	16	,	,	PUNCT
admet-2414	131	17	the	the	DET
admet-2414	131	18	system	system	NOUN
admet-2414	131	19	behaves	behave	VERB
admet-2414	131	20	as	as	SCONJ
admet-2414	131	21	if	if	SCONJ
admet-2414	131	22	it	it	PRON
admet-2414	131	23	has	have	VERB
admet-2414	131	24	an	an	DET
admet-2414	131	25	extremely	extremely	ADV
admet-2414	131	26	high	high	ADJ
admet-2414	131	27	g	g	NOUN
admet-2414	131	28	affinity	affinity	NOUN
admet-2414	131	29	of	of	ADP
admet-2414	131	30	about	about	ADV
admet-2414	131	31	0.0008	0.0008	NUM
admet-2414	131	32	nm	nm	NOUN
admet-2414	131	33	,	,	PUNCT
admet-2414	131	34	6	6	NUM
admet-2414	131	35	thousand	thousand	NUM
admet-2414	131	36	times	time	NOUN
admet-2414	131	37	greater	great	ADJ
admet-2414	131	38	than	than	ADP
admet-2414	131	39	the	the	DET
admet-2414	131	40	experimental	experimental	ADJ
admet-2414	131	41	affinity	affinity	NOUN
admet-2414	131	42	measured	measure	VERB
admet-2414	131	43	at	at	ADP
admet-2414	131	44	high	high	ADJ
admet-2414	131	45	concentrations	concentration	NOUN
admet-2414	131	46	(	(	PUNCT
admet-2414	131	47	kmt	kmt	PROPN
admet-2414	131	48	=	=	SYM
admet-2414	131	49	kmh	kmh	PROPN
admet-2414	131	50	)	)	PUNCT
admet-2414	131	51	of	of	ADP
admet-2414	131	52	5	5	NUM
admet-2414	131	53	nm	nm	NOUN
admet-2414	131	54	!	!	PUNCT
admet-2414	132	1	again	again	ADV
admet-2414	132	2	,	,	PUNCT
admet-2414	132	3	this	this	PRON
admet-2414	132	4	is	be	AUX
admet-2414	132	5	only	only	ADV
admet-2414	132	6	a	a	DET
admet-2414	132	7	rough	rough	ADJ
admet-2414	132	8	estimate	estimate	NOUN
admet-2414	132	9	because	because	SCONJ
admet-2414	132	10	it	it	PRON
admet-2414	132	11	depends	depend	VERB
admet-2414	132	12	on	on	ADP
admet-2414	132	13	the	the	DET
admet-2414	132	14	estimated	estimate	VERB
admet-2414	132	15	values	value	NOUN
admet-2414	132	16	of	of	ADP
admet-2414	132	17	k1	k1	NOUN
admet-2414	132	18	,	,	PUNCT
admet-2414	132	19	k2	k2	PROPN
admet-2414	132	20	,	,	PUNCT
admet-2414	132	21	k3	k3	PROPN
admet-2414	132	22	,	,	PUNCT
admet-2414	132	23	k4	k4	PROPN
admet-2414	132	24	,	,	PUNCT
admet-2414	132	25	k5	k5	PROPN
admet-2414	132	26	and	and	CCONJ
admet-2414	132	27	kc	kc	PROPN
admet-2414	132	28	.	.	PUNCT
admet-2414	133	1	this	this	DET
admet-2414	133	2	apparent	apparent	ADJ
admet-2414	133	3	high	high	ADJ
admet-2414	133	4	affinity	affinity	NOUN
admet-2414	133	5	arises	arise	VERB
admet-2414	133	6	from	from	ADP
admet-2414	133	7	the	the	DET
admet-2414	133	8	peculiar	peculiar	ADJ
admet-2414	133	9	features	feature	NOUN
admet-2414	133	10	of	of	ADP
admet-2414	133	11	the	the	DET
admet-2414	133	12	gr	gr	PROPN
admet-2414	133	13	dynamics	dynamic	NOUN
admet-2414	133	14	,	,	PUNCT
admet-2414	133	15	with	with	ADP
admet-2414	133	16	the	the	DET
admet-2414	133	17	relatively	relatively	ADV
admet-2414	133	18	fast	fast	ADJ
admet-2414	133	19	nuclear	nuclear	ADJ
admet-2414	133	20	import	import	NOUN
admet-2414	133	21	and	and	CCONJ
admet-2414	133	22	slow	slow	VERB
admet-2414	133	23	nuclear	nuclear	ADJ
admet-2414	133	24	export	export	NOUN
admet-2414	133	25	of	of	ADP
admet-2414	133	26	gr	gr	PROPN
admet-2414	133	27	.	.	PUNCT
admet-2414	134	1	the	the	DET
admet-2414	134	2	vmaxl	vmaxl	NOUN
admet-2414	134	3	(=	(=	ADP
admet-2414	134	4	0.0317	0.0317	NUM
admet-2414	134	5	)	)	PUNCT
admet-2414	134	6	of	of	ADP
admet-2414	134	7	this	this	DET
admet-2414	134	8	high	high	ADJ
admet-2414	134	9	-	-	PUNCT
admet-2414	134	10	affinity	affinity	NOUN
admet-2414	134	11	limit	limit	NOUN
admet-2414	134	12	is	be	AUX
admet-2414	134	13	also	also	ADV
admet-2414	134	14	very	very	ADV
admet-2414	134	15	low	low	ADJ
admet-2414	134	16	,	,	PUNCT
admet-2414	134	17	only	only	ADV
admet-2414	134	18	about	about	ADV
admet-2414	134	19	4	4	NUM
admet-2414	134	20	%	%	NOUN
admet-2414	134	21	of	of	ADP
admet-2414	134	22	the	the	DET
admet-2414	134	23	high	high	ADJ
admet-2414	134	24	concentration	concentration	NOUN
admet-2414	134	25	vmaxh	vmaxh	NOUN
admet-2414	134	26	(=	(=	ADP
admet-2414	134	27	0.769	0.769	NUM
admet-2414	134	28	)	)	PUNCT
admet-2414	134	29	and	and	CCONJ
admet-2414	134	30	,	,	PUNCT
admet-2414	134	31	thus	thus	ADV
admet-2414	134	32	,	,	PUNCT
admet-2414	134	33	can	can	AUX
admet-2414	134	34	only	only	ADV
admet-2414	134	35	produce	produce	VERB
admet-2414	134	36	about	about	ADV
admet-2414	134	37	4	4	NUM
admet-2414	134	38	%	%	NOUN
admet-2414	134	39	of	of	ADP
admet-2414	134	40	the	the	DET
admet-2414	134	41	maximum	maximum	ADJ
admet-2414	134	42	transcription	transcription	NOUN
admet-2414	134	43	rate	rate	NOUN
admet-2414	134	44	.	.	PUNCT
admet-2414	135	1	this	this	DET
admet-2414	135	2	result	result	NOUN
admet-2414	135	3	indicates	indicate	VERB
admet-2414	135	4	that	that	SCONJ
admet-2414	135	5	even	even	ADV
admet-2414	135	6	at	at	ADP
admet-2414	135	7	g	g	NOUN
admet-2414	135	8	concentrations	concentration	NOUN
admet-2414	135	9	normally	normally	ADV
admet-2414	135	10	considered	consider	VERB
admet-2414	135	11	negligible	negligible	ADJ
admet-2414	135	12	(	(	PUNCT
admet-2414	135	13	e.g.	e.g.	ADV
admet-2414	135	14	,	,	PUNCT
admet-2414	135	15	dex	dex	NOUN
admet-2414	135	16	concentration	concentration	NOUN
admet-2414	135	17	of	of	ADP
admet-2414	135	18	0.001	0.001	NUM
admet-2414	135	19	nm	nm	NOUN
admet-2414	135	20	)	)	PUNCT
admet-2414	135	21	,	,	PUNCT
admet-2414	135	22	there	there	PRON
admet-2414	135	23	should	should	AUX
admet-2414	135	24	still	still	ADV
admet-2414	135	25	be	be	AUX
admet-2414	135	26	a	a	DET
admet-2414	135	27	residual	residual	ADJ
admet-2414	135	28	transcriptional	transcriptional	ADJ
admet-2414	135	29	activation	activation	NOUN
admet-2414	135	30	rate	rate	NOUN
admet-2414	135	31	of	of	ADP
admet-2414	135	32	about	about	ADV
admet-2414	135	33	4	4	NUM
admet-2414	135	34	%	%	NOUN
admet-2414	135	35	of	of	ADP
admet-2414	135	36	the	the	DET
admet-2414	135	37	maximum	maximum	ADJ
admet-2414	135	38	rate	rate	NOUN
admet-2414	135	39	.	.	PUNCT
admet-2414	136	1	the	the	DET
admet-2414	136	2	value	value	NOUN
admet-2414	136	3	of	of	ADP
admet-2414	136	4	d	d	PROPN
admet-2414	136	5	in	in	ADP
admet-2414	136	6	equation	equation	NOUN
admet-2414	136	7	(	(	PUNCT
admet-2414	136	8	4	4	X
admet-2414	136	9	)	)	PUNCT
admet-2414	136	10	is	be	AUX
admet-2414	136	11	dominated	dominate	VERB
admet-2414	136	12	by	by	ADP
admet-2414	136	13	the	the	DET
admet-2414	136	14	k4	k4	PROPN
admet-2414	136	15	/	/	SYM
admet-2414	136	16	k5	k5	PROPN
admet-2414	136	17	term	term	NOUN
admet-2414	136	18	,	,	PUNCT
admet-2414	136	19	so	so	SCONJ
admet-2414	136	20	that	that	SCONJ
admet-2414	136	21	,	,	PUNCT
admet-2414	136	22	to	to	ADP
admet-2414	136	23	a	a	DET
admet-2414	136	24	first	first	ADJ
admet-2414	136	25	approximation	approximation	NOUN
admet-2414	136	26	,	,	PUNCT
admet-2414	136	27	they	they	PRON
admet-2414	136	28	reduce	reduce	VERB
admet-2414	136	29	to	to	ADP
admet-2414	136	30	equation	equation	NOUN
admet-2414	136	31	(	(	PUNCT
admet-2414	136	32	5	5	NUM
admet-2414	136	33	):	):	PUNCT
admet-2414	136	34	4	4	NUM
admet-2414	136	35	5	5	NUM
admet-2414	136	36	5	5	NUM
admet-2414	136	37	ml	ml	NOUN
admet-2414	136	38	c	c	PROPN
admet-2414	136	39	maxl	maxl	VERB
admet-2414	136	40	tot	tot	NOUN
admet-2414	136	41	5	5	NUM
admet-2414	136	42	1	1	NUM
admet-2414	136	43	4	4	NUM
admet-2414	137	1	k	k	NOUN
admet-2414	137	2	k	k	PROPN
admet-2414	138	1	k	k	PROPN
admet-2414	139	1	d	d	X
admet-2414	139	2	k	k	PROPN
admet-2414	140	1	k	k	X
admet-2414	140	2	v	v	INTJ
admet-2414	140	3	r	r	NOUN
admet-2414	140	4	k	k	PROPN
admet-2414	140	5	k	k	PROPN
admet-2414	140	6	k	k	X
admet-2414	140	7			X
admet-2414	140	8			NOUN
admet-2414	140	9			X
admet-2414	140	10	(	(	PUNCT
admet-2414	140	11	5	5	NUM
admet-2414	140	12	)	)	PUNCT
admet-2414	140	13	as	as	SCONJ
admet-2414	140	14	discussed	discuss	VERB
admet-2414	140	15	above	above	ADV
admet-2414	140	16	,	,	PUNCT
admet-2414	140	17	although	although	SCONJ
admet-2414	140	18	k5	k5	PROPN
admet-2414	140	19	can	can	AUX
admet-2414	140	20	be	be	AUX
admet-2414	140	21	directly	directly	ADV
admet-2414	140	22	measured	measure	VERB
admet-2414	140	23	,	,	PUNCT
admet-2414	140	24	there	there	PRON
admet-2414	140	25	are	be	VERB
admet-2414	140	26	no	no	DET
admet-2414	140	27	experimental	experimental	ADJ
admet-2414	140	28	measurements	measurement	NOUN
admet-2414	140	29	of	of	ADP
admet-2414	140	30	k1	k1	NOUN
admet-2414	140	31	and	and	CCONJ
admet-2414	140	32	its	its	PRON
admet-2414	140	33	assumed	assume	VERB
admet-2414	140	34	value	value	NOUN
admet-2414	140	35	of	of	ADP
admet-2414	140	36	10	10	NUM
admet-2414	140	37	min-1	min-1	NOUN
admet-2414	140	38	in	in	ADP
admet-2414	140	39	table	table	NOUN
admet-2414	140	40	1	1	NUM
admet-2414	140	41	was	be	AUX
admet-2414	140	42	just	just	ADV
admet-2414	140	43	a	a	DET
admet-2414	140	44	guess	guess	NOUN
admet-2414	140	45	.	.	PUNCT
admet-2414	141	1	thus	thus	ADV
admet-2414	141	2	,	,	PUNCT
admet-2414	141	3	the	the	DET
admet-2414	141	4	apparent	apparent	ADJ
admet-2414	141	5	km	km	NOUN
admet-2414	141	6	at	at	ADP
admet-2414	141	7	very	very	ADV
admet-2414	141	8	low	low	ADJ
admet-2414	141	9	concentrations	concentration	NOUN
admet-2414	141	10	(=	(=	X
admet-2414	141	11	kml	kml	PROPN
admet-2414	141	12	)	)	PUNCT
admet-2414	141	13	,	,	PUNCT
admet-2414	141	14	which	which	PRON
admet-2414	141	15	is	be	AUX
admet-2414	141	16	inversely	inversely	ADV
admet-2414	141	17	proportional	proportional	ADJ
admet-2414	141	18	to	to	ADP
admet-2414	141	19	k1	k1	PROPN
admet-2414	141	20	is	be	AUX
admet-2414	141	21	highly	highly	ADV
admet-2414	141	22	uncertain	uncertain	ADJ
admet-2414	141	23	.	.	PUNCT
admet-2414	142	1	however	however	ADV
admet-2414	142	2	,	,	PUNCT
admet-2414	142	3	the	the	DET
admet-2414	142	4	conclusion	conclusion	NOUN
admet-2414	142	5	that	that	SCONJ
admet-2414	142	6	at	at	ADP
admet-2414	142	7	low	low	ADJ
admet-2414	142	8	concentrations	concentration	NOUN
admet-2414	142	9	,	,	PUNCT
admet-2414	142	10	there	there	PRON
admet-2414	142	11	is	be	VERB
admet-2414	142	12	very	very	ADV
admet-2414	142	13	high	high	ADJ
admet-2414	142	14	affinity	affinity	NOUN
admet-2414	142	15	is	be	AUX
admet-2414	142	16	relatively	relatively	ADV
admet-2414	142	17	robust	robust	ADJ
admet-2414	142	18	because	because	SCONJ
admet-2414	142	19	even	even	ADV
admet-2414	142	20	if	if	SCONJ
admet-2414	142	21	k1	k1	NOUN
admet-2414	142	22	is	be	AUX
admet-2414	142	23	only	only	ADV
admet-2414	142	24	1	1	NUM
admet-2414	142	25	min-1	min-1	NOUN
admet-2414	142	26	(	(	PUNCT
admet-2414	142	27	the	the	DET
admet-2414	142	28	absolute	absolute	ADJ
admet-2414	142	29	limit	limit	NOUN
admet-2414	142	30	allowed	allow	VERB
admet-2414	142	31	by	by	ADP
admet-2414	142	32	the	the	DET
admet-2414	142	33	experimental	experimental	ADJ
admet-2414	142	34	results	result	NOUN
admet-2414	142	35	)	)	PUNCT
admet-2414	142	36	,	,	PUNCT
admet-2414	142	37	ten	ten	NUM
admet-2414	142	38	times	time	NOUN
admet-2414	142	39	slower	slow	ADJ
admet-2414	142	40	than	than	SCONJ
admet-2414	142	41	assumed	assume	VERB
admet-2414	142	42	in	in	ADP
admet-2414	142	43	table	table	NOUN
admet-2414	142	44	1	1	NUM
admet-2414	142	45	,	,	PUNCT
admet-2414	142	46	kml	kml	PROPN
admet-2414	143	1	=	=	PROPN
admet-2414	143	2	0.0079	0.0079	NUM
admet-2414	143	3	nm	nm	PROPN
admet-2414	143	4	,	,	PUNCT
admet-2414	143	5	still	still	ADV
admet-2414	143	6	an	an	DET
admet-2414	143	7	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	143	8	d.	d.	PROPN
admet-2414	143	9	g.	g.	PROPN
admet-2414	143	10	levitt	levitt	PROPN
admet-2414	143	11	admet	admet	PROPN
admet-2414	143	12	&	&	CCONJ
admet-2414	143	13	dmpk	dmpk	PROPN
admet-2414	143	14	12(6	12(6	NUM
admet-2414	143	15	)	)	PUNCT
admet-2414	143	16	(	(	PUNCT
admet-2414	143	17	2024	2024	NUM
admet-2414	143	18	)	)	PUNCT
admet-2414	143	19	971	971	NUM
admet-2414	143	20	-	-	SYM
admet-2414	143	21	989	989	NUM
admet-2414	143	22	976	976	NUM
admet-2414	143	23	extremely	extremely	ADV
admet-2414	143	24	high	high	ADJ
admet-2414	143	25	affinity	affinity	NOUN
admet-2414	143	26	.	.	PUNCT
admet-2414	144	1	in	in	ADP
admet-2414	144	2	contrast	contrast	NOUN
admet-2414	144	3	,	,	PUNCT
admet-2414	144	4	the	the	DET
admet-2414	144	5	parameters	parameter	NOUN
admet-2414	144	6	that	that	PRON
admet-2414	144	7	determine	determine	VERB
admet-2414	144	8	vmaxl	vmaxl	NOUN
admet-2414	144	9	are	be	AUX
admet-2414	144	10	reasonably	reasonably	ADV
admet-2414	144	11	well	well	ADV
admet-2414	144	12	constrained	constrain	VERB
admet-2414	144	13	by	by	ADP
admet-2414	144	14	the	the	DET
admet-2414	144	15	time	time	NOUN
admet-2414	144	16	-	-	PUNCT
admet-2414	144	17	dependent	dependent	ADJ
admet-2414	144	18	experiments	experiment	NOUN
admet-2414	144	19	,	,	PUNCT
admet-2414	144	20	and	and	CCONJ
admet-2414	144	21	the	the	DET
admet-2414	144	22	above	above	ADJ
admet-2414	144	23	estimate	estimate	NOUN
admet-2414	144	24	is	be	AUX
admet-2414	144	25	probably	probably	ADV
admet-2414	144	26	accurate	accurate	ADJ
admet-2414	144	27	within	within	ADP
admet-2414	144	28	a	a	DET
admet-2414	144	29	factor	factor	NOUN
admet-2414	144	30	of	of	ADP
admet-2414	144	31	2	2	NUM
admet-2414	144	32	.	.	PUNCT
admet-2414	145	1	figure	figure	NOUN
admet-2414	145	2	2	2	NUM
admet-2414	145	3	.	.	PUNCT
admet-2414	145	4	fraction	fraction	NOUN
admet-2414	145	5	of	of	ADP
admet-2414	145	6	receptor	receptor	NOUN
admet-2414	145	7	that	that	PRON
admet-2414	145	8	is	be	AUX
admet-2414	145	9	located	locate	VERB
admet-2414	145	10	in	in	ADP
admet-2414	145	11	the	the	DET
admet-2414	145	12	nucleus	nucleus	NOUN
admet-2414	145	13	as	as	ADP
admet-2414	145	14	a	a	DET
admet-2414	145	15	function	function	NOUN
admet-2414	145	16	of	of	ADP
admet-2414	145	17	glucocorticoid	glucocorticoid	ADJ
admet-2414	145	18	concentration	concentration	NOUN
admet-2414	145	19	using	use	VERB
admet-2414	145	20	the	the	DET
admet-2414	145	21	dexamethasone	dexamethasone	NOUN
admet-2414	145	22	parameters	parameter	NOUN
admet-2414	145	23	in	in	ADP
admet-2414	145	24	table	table	NOUN
admet-2414	145	25	1	1	NUM
admet-2414	145	26	steady	steady	ADJ
admet-2414	145	27	-	-	PUNCT
admet-2414	145	28	state	state	NOUN
admet-2414	145	29	model	model	NOUN
admet-2414	145	30	predictions	prediction	NOUN
admet-2414	145	31	for	for	ADP
admet-2414	145	32	dexamethasone	dexamethasone	NOUN
admet-2414	145	33	and	and	CCONJ
admet-2414	145	34	cortisol	cortisol	NOUN
admet-2414	145	35	using	use	VERB
admet-2414	145	36	the	the	DET
admet-2414	145	37	above	above	ADV
admet-2414	145	38	estimated	estimate	VERB
admet-2414	145	39	model	model	NOUN
admet-2414	145	40	parameter	parameter	NOUN
admet-2414	145	41	set	set	NOUN
admet-2414	145	42	(	(	PUNCT
admet-2414	145	43	table	table	NOUN
admet-2414	145	44	1	1	NUM
admet-2414	145	45	)	)	PUNCT
admet-2414	145	46	,	,	PUNCT
admet-2414	145	47	the	the	DET
admet-2414	145	48	quantitative	quantitative	ADJ
admet-2414	145	49	properties	property	NOUN
admet-2414	145	50	of	of	ADP
admet-2414	145	51	the	the	DET
admet-2414	145	52	model	model	NOUN
admet-2414	145	53	will	will	AUX
admet-2414	145	54	be	be	AUX
admet-2414	145	55	discussed	discuss	VERB
admet-2414	145	56	in	in	ADP
admet-2414	145	57	this	this	DET
admet-2414	145	58	section	section	NOUN
admet-2414	145	59	.	.	PUNCT
admet-2414	146	1	figure	figure	NOUN
admet-2414	146	2	2	2	NUM
admet-2414	146	3	shows	show	VERB
admet-2414	146	4	a	a	DET
admet-2414	146	5	plot	plot	NOUN
admet-2414	146	6	of	of	ADP
admet-2414	146	7	the	the	DET
admet-2414	146	8	steady	steady	ADJ
admet-2414	146	9	state	state	NOUN
admet-2414	146	10	fraction	fraction	NOUN
admet-2414	146	11	of	of	ADP
admet-2414	146	12	the	the	DET
admet-2414	146	13	receptor	receptor	NOUN
admet-2414	146	14	that	that	PRON
admet-2414	146	15	is	be	AUX
admet-2414	146	16	in	in	ADP
admet-2414	146	17	the	the	DET
admet-2414	146	18	nucleus	nucleus	NOUN
admet-2414	146	19	(=	(=	X
admet-2414	146	20	rn	rn	PROPN
admet-2414	146	21	+	+	CCONJ
admet-2414	146	22	rng+rngt+rngn	rng+rngt+rngn	PROPN
admet-2414	146	23	)	)	PUNCT
admet-2414	146	24	as	as	ADP
admet-2414	146	25	a	a	DET
admet-2414	146	26	function	function	NOUN
admet-2414	146	27	of	of	ADP
admet-2414	146	28	the	the	DET
admet-2414	146	29	dex	dex	NOUN
admet-2414	146	30	concentration	concentration	NOUN
admet-2414	146	31	.	.	PUNCT
admet-2414	147	1	a	a	DET
admet-2414	147	2	dex	dex	NOUN
admet-2414	147	3	concentration	concentration	NOUN
admet-2414	147	4	of	of	ADP
admet-2414	147	5	only	only	ADV
admet-2414	147	6	about	about	ADV
admet-2414	147	7	0.01	0.01	NUM
admet-2414	147	8	nm	nm	NOUN
admet-2414	147	9	is	be	AUX
admet-2414	147	10	enough	enough	ADJ
admet-2414	147	11	to	to	PART
admet-2414	147	12	shift	shift	VERB
admet-2414	147	13	90	90	NUM
admet-2414	147	14	%	%	NOUN
admet-2414	147	15	of	of	ADP
admet-2414	147	16	the	the	DET
admet-2414	147	17	receptor	receptor	NOUN
admet-2414	147	18	to	to	ADP
admet-2414	147	19	the	the	DET
admet-2414	147	20	nucleus	nucleus	NOUN
admet-2414	147	21	.	.	PUNCT
admet-2414	148	1	a	a	DET
admet-2414	148	2	b	b	NOUN
admet-2414	148	3	c	c	X
admet-2414	148	4	figure	figure	NOUN
admet-2414	148	5	3	3	NUM
admet-2414	148	6	.	.	NOUN
admet-2414	148	7	steady	steady	ADJ
admet-2414	148	8	state	state	NOUN
admet-2414	148	9	glucocorticoid	glucocorticoid	ADJ
admet-2414	148	10	concentration	concentration	NOUN
admet-2414	148	11	dependence	dependence	NOUN
admet-2414	148	12	of	of	ADP
admet-2414	148	13	the	the	DET
admet-2414	148	14	fraction	fraction	NOUN
admet-2414	148	15	of	of	ADP
admet-2414	148	16	receptor	receptor	NOUN
admet-2414	148	17	that	that	PRON
admet-2414	148	18	is	be	AUX
admet-2414	148	19	in	in	ADP
admet-2414	148	20	the	the	DET
admet-2414	148	21	state	state	NOUN
admet-2414	148	22	rngn	rngn	NOUN
admet-2414	148	23	(	(	PUNCT
admet-2414	148	24	see	see	VERB
admet-2414	148	25	figure	figure	NOUN
admet-2414	148	26	1	1	NUM
admet-2414	148	27	)	)	PUNCT
admet-2414	148	28	that	that	PRON
admet-2414	148	29	can	can	AUX
admet-2414	148	30	potentially	potentially	ADV
admet-2414	148	31	modify	modify	VERB
admet-2414	148	32	the	the	DET
admet-2414	148	33	transcription	transcription	NOUN
admet-2414	148	34	rate	rate	NOUN
admet-2414	148	35	for	for	ADP
admet-2414	148	36	the	the	DET
admet-2414	148	37	high	high	ADJ
admet-2414	148	38	-	-	PUNCT
admet-2414	148	39	affinity	affinity	NOUN
admet-2414	148	40	dexamethasone	dexamethasone	NOUN
admet-2414	148	41	(	(	PUNCT
admet-2414	148	42	table	table	NOUN
admet-2414	148	43	1	1	NUM
admet-2414	148	44	)	)	PUNCT
admet-2414	148	45	with	with	ADP
admet-2414	148	46	its	its	PRON
admet-2414	148	47	apparent	apparent	ADJ
admet-2414	148	48	experimental	experimental	ADJ
admet-2414	148	49	transcriptional	transcriptional	ADJ
admet-2414	148	50	kmt	kmt	NOUN
admet-2414	148	51	of	of	ADP
admet-2414	148	52	5	5	NUM
admet-2414	148	53	nm	nm	NOUN
admet-2414	148	54	.	.	PUNCT
admet-2414	149	1	three	three	NUM
admet-2414	149	2	different	different	ADJ
admet-2414	149	3	concentration	concentration	NOUN
admet-2414	149	4	ranges	range	NOUN
admet-2414	149	5	are	be	AUX
admet-2414	149	6	shown	show	VERB
admet-2414	149	7	:	:	PUNCT
admet-2414	149	8	very	very	ADV
admet-2414	149	9	low	low	ADJ
admet-2414	149	10	(	(	PUNCT
admet-2414	149	11	a	a	NOUN
admet-2414	149	12	)	)	PUNCT
admet-2414	149	13	,	,	PUNCT
admet-2414	149	14	intermediate	intermediate	ADJ
admet-2414	149	15	(	(	PUNCT
admet-2414	149	16	b	b	NOUN
admet-2414	149	17	)	)	PUNCT
admet-2414	149	18	and	and	CCONJ
admet-2414	149	19	high	high	ADJ
admet-2414	149	20	concentration	concentration	NOUN
admet-2414	149	21	(	(	PUNCT
admet-2414	149	22	c	c	NOUN
admet-2414	149	23	)	)	PUNCT
admet-2414	149	24	.	.	PUNCT
admet-2414	150	1	the	the	DET
admet-2414	150	2	black	black	ADJ
admet-2414	150	3	line	line	NOUN
admet-2414	150	4	is	be	AUX
admet-2414	150	5	the	the	DET
admet-2414	150	6	exact	exact	ADJ
admet-2414	150	7	solution	solution	NOUN
admet-2414	150	8	(	(	PUNCT
admet-2414	150	9	equation	equation	NOUN
admet-2414	150	10	2	2	NUM
admet-2414	150	11	)	)	PUNCT
admet-2414	150	12	,	,	PUNCT
admet-2414	150	13	the	the	DET
admet-2414	150	14	red	red	ADJ
admet-2414	150	15	line	line	NOUN
admet-2414	150	16	is	be	AUX
admet-2414	150	17	the	the	DET
admet-2414	150	18	high	high	ADJ
admet-2414	150	19	concentration	concentration	NOUN
admet-2414	150	20	approximation	approximation	NOUN
admet-2414	150	21	(	(	PUNCT
admet-2414	150	22	equation	equation	NOUN
admet-2414	150	23	3	3	NUM
admet-2414	150	24	)	)	PUNCT
admet-2414	150	25	and	and	CCONJ
admet-2414	150	26	the	the	DET
admet-2414	150	27	blue	blue	ADJ
admet-2414	150	28	line	line	NOUN
admet-2414	150	29	is	be	AUX
admet-2414	150	30	the	the	DET
admet-2414	150	31	low	low	ADJ
admet-2414	150	32	concentration	concentration	NOUN
admet-2414	150	33	approximation	approximation	NOUN
admet-2414	150	34	(	(	PUNCT
admet-2414	150	35	equation	equation	NOUN
admet-2414	150	36	4	4	NUM
admet-2414	150	37	)	)	PUNCT
admet-2414	150	38	admet	admet	PROPN
admet-2414	150	39	&	&	CCONJ
admet-2414	150	40	dmpk	dmpk	PROPN
admet-2414	150	41	12(6	12(6	NUM
admet-2414	150	42	)	)	PUNCT
admet-2414	150	43	(	(	PUNCT
admet-2414	150	44	2024	2024	NUM
admet-2414	150	45	)	)	PUNCT
admet-2414	150	46	971	971	NUM
admet-2414	150	47	-	-	SYM
admet-2414	150	48	989	989	NUM
admet-2414	150	49	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	150	50	/	/	SYM
admet-2414	150	51	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	150	52	of	of	ADP
admet-2414	150	53	glucocorticoids	glucocorticoid	NOUN
admet-2414	150	54	doi	doi	NOUN
admet-2414	150	55	:	:	PUNCT
admet-2414	150	56	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	150	57	977	977	NUM
admet-2414	150	58	figure	figure	NOUN
admet-2414	150	59	3	3	NUM
admet-2414	150	60	shows	show	VERB
admet-2414	150	61	a	a	DET
admet-2414	150	62	plot	plot	NOUN
admet-2414	150	63	of	of	ADP
admet-2414	150	64	the	the	DET
admet-2414	150	65	dex	dex	NOUN
admet-2414	150	66	concentration	concentration	NOUN
admet-2414	150	67	dependence	dependence	NOUN
admet-2414	150	68	of	of	ADP
admet-2414	150	69	the	the	DET
admet-2414	150	70	steady	steady	ADJ
admet-2414	150	71	-	-	PUNCT
admet-2414	150	72	state	state	NOUN
admet-2414	150	73	fraction	fraction	NOUN
admet-2414	150	74	of	of	ADP
admet-2414	150	75	the	the	DET
admet-2414	150	76	gr	gr	NOUN
admet-2414	150	77	that	that	PRON
admet-2414	150	78	is	be	AUX
admet-2414	150	79	in	in	ADP
admet-2414	150	80	the	the	DET
admet-2414	150	81	rngn	rngn	NOUN
admet-2414	150	82	state	state	NOUN
admet-2414	150	83	that	that	PRON
admet-2414	150	84	can	can	AUX
admet-2414	150	85	potentially	potentially	ADV
admet-2414	150	86	modulate	modulate	VERB
admet-2414	150	87	transcription	transcription	NOUN
admet-2414	150	88	.	.	PUNCT
admet-2414	151	1	the	the	DET
admet-2414	151	2	black	black	ADJ
admet-2414	151	3	line	line	NOUN
admet-2414	151	4	is	be	AUX
admet-2414	151	5	the	the	DET
admet-2414	151	6	exact	exact	ADJ
admet-2414	151	7	solution	solution	NOUN
admet-2414	151	8	(	(	PUNCT
admet-2414	151	9	equation	equation	NOUN
admet-2414	151	10	(	(	PUNCT
admet-2414	151	11	2	2	NUM
admet-2414	151	12	)	)	PUNCT
admet-2414	151	13	)	)	PUNCT
admet-2414	151	14	,	,	PUNCT
admet-2414	151	15	the	the	DET
admet-2414	151	16	red	red	ADJ
admet-2414	151	17	line	line	NOUN
admet-2414	151	18	is	be	AUX
admet-2414	151	19	the	the	DET
admet-2414	151	20	high	high	ADJ
admet-2414	151	21	-	-	PUNCT
admet-2414	151	22	concentration	concentration	NOUN
admet-2414	151	23	approximation	approximation	NOUN
admet-2414	151	24	(	(	PUNCT
admet-2414	151	25	equation	equation	NOUN
admet-2414	151	26	(	(	PUNCT
admet-2414	151	27	3	3	NUM
admet-2414	151	28	)	)	PUNCT
admet-2414	151	29	)	)	PUNCT
admet-2414	151	30	and	and	CCONJ
admet-2414	151	31	the	the	DET
admet-2414	151	32	blue	blue	ADJ
admet-2414	151	33	line	line	NOUN
admet-2414	151	34	is	be	AUX
admet-2414	151	35	the	the	DET
admet-2414	151	36	low	low	ADJ
admet-2414	151	37	-	-	PUNCT
admet-2414	151	38	concentration	concentration	NOUN
admet-2414	151	39	approximation	approximation	NOUN
admet-2414	151	40	(	(	PUNCT
admet-2414	151	41	equation	equation	NOUN
admet-2414	151	42	(	(	PUNCT
admet-2414	151	43	4	4	NUM
admet-2414	151	44	)	)	PUNCT
admet-2414	151	45	)	)	PUNCT
admet-2414	151	46	.	.	PUNCT
admet-2414	152	1	the	the	DET
admet-2414	152	2	top	top	ADJ
admet-2414	152	3	panel	panel	NOUN
admet-2414	152	4	shows	show	VERB
admet-2414	152	5	the	the	DET
admet-2414	152	6	predicted	predict	VERB
admet-2414	152	7	extremely	extremely	ADV
admet-2414	152	8	high	high	ADJ
admet-2414	152	9	apparent	apparent	ADJ
admet-2414	152	10	affinity	affinity	NOUN
admet-2414	152	11	(	(	PUNCT
admet-2414	152	12	0.0008	0.0008	NUM
admet-2414	152	13	nm	nm	NOUN
admet-2414	152	14	)	)	PUNCT
admet-2414	152	15	predicted	predict	VERB
admet-2414	152	16	by	by	ADP
admet-2414	152	17	equation	equation	NOUN
admet-2414	152	18	(	(	PUNCT
admet-2414	152	19	4	4	NUM
admet-2414	152	20	)	)	PUNCT
admet-2414	152	21	in	in	ADP
admet-2414	152	22	the	the	DET
admet-2414	152	23	low	low	ADJ
admet-2414	152	24	concentration	concentration	NOUN
admet-2414	152	25	limit	limit	NOUN
admet-2414	152	26	.	.	PUNCT
admet-2414	153	1	similarly	similarly	ADV
admet-2414	153	2	,	,	PUNCT
admet-2414	153	3	the	the	DET
admet-2414	153	4	bottom	bottom	ADJ
admet-2414	153	5	panel	panel	NOUN
admet-2414	153	6	shows	show	VERB
admet-2414	153	7	that	that	SCONJ
admet-2414	153	8	a	a	DET
admet-2414	153	9	michaelismenten	michaelismenten	VERB
admet-2414	153	10	equation	equation	NOUN
admet-2414	153	11	with	with	ADP
admet-2414	153	12	the	the	DET
admet-2414	153	13	apparent	apparent	ADJ
admet-2414	153	14	kmh=	kmh=	NOUN
admet-2414	153	15	kmt	kmt	PROPN
admet-2414	153	16	of	of	ADP
admet-2414	153	17	5	5	NUM
admet-2414	153	18	nm	nm	PRON
admet-2414	153	19	predicted	predict	VERB
admet-2414	153	20	by	by	ADP
admet-2414	153	21	equation	equation	NOUN
admet-2414	153	22	(	(	PUNCT
admet-2414	153	23	4	4	X
admet-2414	153	24	)	)	PUNCT
admet-2414	153	25	provides	provide	VERB
admet-2414	153	26	a	a	DET
admet-2414	153	27	good	good	ADJ
admet-2414	153	28	fit	fit	NOUN
admet-2414	153	29	to	to	ADP
admet-2414	153	30	the	the	DET
admet-2414	153	31	high	high	ADJ
admet-2414	153	32	concentration	concentration	NOUN
admet-2414	153	33	range	range	NOUN
admet-2414	153	34	over	over	ADP
admet-2414	153	35	which	which	PRON
admet-2414	153	36	experimental	experimental	ADJ
admet-2414	153	37	pd	pd	PROPN
admet-2414	153	38	measurements	measurement	NOUN
admet-2414	153	39	are	be	AUX
admet-2414	153	40	usually	usually	ADV
admet-2414	153	41	made	make	VERB
admet-2414	153	42	.	.	PUNCT
admet-2414	154	1	figure	figure	VERB
admet-2414	154	2	4	4	NUM
admet-2414	154	3	shows	show	VERB
admet-2414	154	4	a	a	DET
admet-2414	154	5	similar	similar	ADJ
admet-2414	154	6	plot	plot	NOUN
admet-2414	154	7	for	for	ADP
admet-2414	154	8	the	the	DET
admet-2414	154	9	low	low	ADJ
admet-2414	154	10	-	-	PUNCT
admet-2414	154	11	affinity	affinity	NOUN
admet-2414	154	12	cortisol	cortisol	NOUN
admet-2414	154	13	.	.	PUNCT
admet-2414	155	1	it	it	PRON
admet-2414	155	2	is	be	AUX
admet-2414	155	3	assumed	assume	VERB
admet-2414	155	4	that	that	SCONJ
admet-2414	155	5	the	the	DET
admet-2414	155	6	only	only	ADJ
admet-2414	155	7	parameters	parameter	NOUN
admet-2414	155	8	that	that	PRON
admet-2414	155	9	are	be	AUX
admet-2414	155	10	g	g	NOUN
admet-2414	155	11	-	-	PUNCT
admet-2414	155	12	dependent	dependent	ADJ
admet-2414	155	13	are	be	AUX
admet-2414	155	14	the	the	DET
admet-2414	155	15	two	two	NUM
admet-2414	155	16	binding	bind	VERB
admet-2414	155	17	constants	constant	NOUN
admet-2414	155	18	(	(	PUNCT
admet-2414	155	19	kc	kc	PROPN
admet-2414	155	20	and	and	CCONJ
admet-2414	155	21	kn	kn	PROPN
admet-2414	155	22	)	)	PUNCT
admet-2414	155	23	and	and	CCONJ
admet-2414	155	24	that	that	SCONJ
admet-2414	155	25	the	the	DET
admet-2414	155	26	rate	rate	NOUN
admet-2414	155	27	constants	constant	NOUN
admet-2414	155	28	are	be	AUX
admet-2414	155	29	not	not	PART
admet-2414	155	30	g	g	NOUN
admet-2414	155	31	-	-	PUNCT
admet-2414	155	32	dependent	dependent	ADJ
admet-2414	155	33	(	(	PUNCT
admet-2414	155	34	see	see	VERB
admet-2414	155	35	table	table	NOUN
admet-2414	155	36	1	1	NUM
admet-2414	155	37	)	)	PUNCT
admet-2414	155	38	.	.	PUNCT
admet-2414	156	1	cortisol	cortisol	PROPN
admet-2414	156	2	has	have	VERB
admet-2414	156	3	a	a	DET
admet-2414	156	4	fifteen	fifteen	ADJ
admet-2414	156	5	-	-	ADJ
admet-2414	156	6	fold	fold	ADJ
admet-2414	156	7	lower	low	ADJ
admet-2414	156	8	affinity	affinity	NOUN
admet-2414	156	9	than	than	ADP
admet-2414	156	10	dex	dex	NOUN
admet-2414	156	11	for	for	ADP
admet-2414	156	12	the	the	DET
admet-2414	156	13	cytoplasmic	cytoplasmic	ADJ
admet-2414	156	14	receptor	receptor	NOUN
admet-2414	156	15	at	at	ADP
admet-2414	156	16	0	0	NUM
admet-2414	156	17	°	°	ADP
admet-2414	156	18	c	c	NOUN
admet-2414	156	19	(	(	PUNCT
admet-2414	156	20	15	15	NUM
admet-2414	156	21	nm	nm	NOUN
admet-2414	156	22	for	for	ADP
admet-2414	156	23	cortisol	cortisol	NOUN
admet-2414	156	24	versus	versus	ADP
admet-2414	156	25	1.1	1.1	NUM
admet-2414	156	26	nm	nm	NOUN
admet-2414	156	27	for	for	ADP
admet-2414	156	28	dex)[26	dex)[26	PROPN
admet-2414	156	29	]	]	PUNCT
admet-2414	156	30	.	.	PUNCT
admet-2414	157	1	making	make	VERB
admet-2414	157	2	the	the	DET
admet-2414	157	3	same	same	ADJ
admet-2414	157	4	assumption	assumption	NOUN
admet-2414	157	5	that	that	SCONJ
admet-2414	157	6	the	the	DET
admet-2414	157	7	37	37	NUM
admet-2414	157	8	°	°	NOUN
admet-2414	157	9	c	c	NOUN
admet-2414	157	10	affinity	affinity	NOUN
admet-2414	157	11	is	be	AUX
admet-2414	157	12	fivefold	fivefold	ADV
admet-2414	157	13	less	less	ADV
admet-2414	157	14	,	,	PUNCT
admet-2414	157	15	the	the	DET
admet-2414	157	16	cortisol	cortisol	ADJ
admet-2414	157	17	affinity	affinity	NOUN
admet-2414	157	18	kc	kc	PROPN
admet-2414	157	19	is	be	AUX
admet-2414	157	20	assumed	assume	VERB
admet-2414	157	21	to	to	PART
admet-2414	157	22	be	be	AUX
admet-2414	157	23	75	75	NUM
admet-2414	157	24	nm	nm	NOUN
admet-2414	157	25	.	.	PUNCT
admet-2414	158	1	the	the	DET
admet-2414	158	2	experimental	experimental	ADJ
admet-2414	158	3	kmt	kmt	PROPN
admet-2414	158	4	for	for	ADP
admet-2414	158	5	transcriptional	transcriptional	ADJ
admet-2414	158	6	modulation	modulation	NOUN
admet-2414	158	7	by	by	ADP
admet-2414	158	8	cortisol	cortisol	NOUN
admet-2414	158	9	ranges	range	VERB
admet-2414	158	10	from	from	ADP
admet-2414	158	11	35	35	NUM
admet-2414	158	12	to	to	ADP
admet-2414	158	13	67	67	NUM
admet-2414	158	14	nm	nm	NOUN
admet-2414	158	15	for	for	ADP
admet-2414	158	16	various	various	ADJ
admet-2414	158	17	cell	cell	NOUN
admet-2414	158	18	lines	line	NOUN
admet-2414	159	1	[	[	X
admet-2414	159	2	30,31	30,31	NUM
admet-2414	159	3	]	]	PUNCT
admet-2414	159	4	,	,	PUNCT
admet-2414	159	5	and	and	CCONJ
admet-2414	159	6	it	it	PRON
admet-2414	159	7	will	will	AUX
admet-2414	159	8	be	be	AUX
admet-2414	159	9	assumed	assume	VERB
admet-2414	159	10	that	that	SCONJ
admet-2414	159	11	it	it	PRON
admet-2414	159	12	is	be	AUX
admet-2414	159	13	50	50	NUM
admet-2414	159	14	nm	nm	NOUN
admet-2414	159	15	,	,	PUNCT
admet-2414	159	16	10	10	NUM
admet-2414	159	17	times	time	NOUN
admet-2414	159	18	that	that	PRON
admet-2414	159	19	of	of	ADP
admet-2414	159	20	dex	dex	NOUN
admet-2414	159	21	.	.	PUNCT
admet-2414	160	1	from	from	ADP
admet-2414	160	2	equation	equation	NOUN
admet-2414	160	3	(	(	PUNCT
admet-2414	160	4	3	3	NUM
admet-2414	160	5	)	)	PUNCT
admet-2414	160	6	,	,	PUNCT
admet-2414	160	7	this	this	PRON
admet-2414	160	8	corresponds	correspond	VERB
admet-2414	160	9	to	to	ADP
admet-2414	160	10	a	a	DET
admet-2414	160	11	cortisol	cortisol	ADJ
admet-2414	160	12	kn	kn	NOUN
admet-2414	160	13	of	of	ADP
admet-2414	160	14	1550	1550	NUM
admet-2414	160	15	nm	nm	NOUN
admet-2414	160	16	(	(	PUNCT
admet-2414	160	17	table	table	NOUN
admet-2414	160	18	1	1	NUM
admet-2414	160	19	)	)	PUNCT
admet-2414	160	20	.	.	PUNCT
admet-2414	161	1	a	a	DET
admet-2414	161	2	b	b	NOUN
admet-2414	161	3	c	c	X
admet-2414	161	4	figure	figure	NOUN
admet-2414	161	5	4	4	NUM
admet-2414	161	6	.	.	NOUN
admet-2414	161	7	steady	steady	ADJ
admet-2414	161	8	state	state	NOUN
admet-2414	161	9	glucocorticoid	glucocorticoid	ADJ
admet-2414	161	10	concentration	concentration	NOUN
admet-2414	161	11	(	(	PUNCT
admet-2414	161	12	nm	nm	NOUN
admet-2414	161	13	)	)	PUNCT
admet-2414	161	14	dependence	dependence	NOUN
admet-2414	161	15	of	of	ADP
admet-2414	161	16	the	the	DET
admet-2414	161	17	fraction	fraction	NOUN
admet-2414	161	18	of	of	ADP
admet-2414	161	19	receptor	receptor	NOUN
admet-2414	161	20	that	that	PRON
admet-2414	161	21	is	be	AUX
admet-2414	161	22	in	in	ADP
admet-2414	161	23	the	the	DET
admet-2414	161	24	state	state	NOUN
admet-2414	161	25	rngn	rngn	NOUN
admet-2414	161	26	(	(	PUNCT
admet-2414	161	27	see	see	VERB
admet-2414	161	28	figure	figure	NOUN
admet-2414	161	29	1	1	NUM
admet-2414	161	30	)	)	PUNCT
admet-2414	161	31	that	that	PRON
admet-2414	161	32	can	can	AUX
admet-2414	161	33	potentially	potentially	ADV
admet-2414	161	34	modify	modify	VERB
admet-2414	161	35	the	the	DET
admet-2414	161	36	transcription	transcription	NOUN
admet-2414	161	37	rate	rate	NOUN
admet-2414	161	38	for	for	ADP
admet-2414	161	39	the	the	DET
admet-2414	161	40	low	low	ADJ
admet-2414	161	41	-	-	PUNCT
admet-2414	161	42	affinity	affinity	NOUN
admet-2414	161	43	cortisol	cortisol	NOUN
admet-2414	161	44	(	(	PUNCT
admet-2414	161	45	table	table	NOUN
admet-2414	161	46	1	1	NUM
admet-2414	161	47	)	)	PUNCT
admet-2414	161	48	with	with	ADP
admet-2414	161	49	its	its	PRON
admet-2414	161	50	apparent	apparent	ADJ
admet-2414	161	51	experimental	experimental	ADJ
admet-2414	161	52	transcriptional	transcriptional	ADJ
admet-2414	161	53	kmt	kmt	NOUN
admet-2414	161	54	of	of	ADP
admet-2414	161	55	50	50	NUM
admet-2414	161	56	nm	nm	NOUN
admet-2414	161	57	.	.	PUNCT
admet-2414	162	1	three	three	NUM
admet-2414	162	2	different	different	ADJ
admet-2414	162	3	concentration	concentration	NOUN
admet-2414	162	4	ranges	range	NOUN
admet-2414	162	5	are	be	AUX
admet-2414	162	6	shown	show	VERB
admet-2414	162	7	:	:	PUNCT
admet-2414	162	8	very	very	ADV
admet-2414	162	9	low	low	ADJ
admet-2414	162	10	(	(	PUNCT
admet-2414	162	11	a	a	NOUN
admet-2414	162	12	)	)	PUNCT
admet-2414	162	13	,	,	PUNCT
admet-2414	162	14	intermediate	intermediate	ADJ
admet-2414	162	15	(	(	PUNCT
admet-2414	162	16	b	b	NOUN
admet-2414	162	17	)	)	PUNCT
admet-2414	162	18	and	and	CCONJ
admet-2414	162	19	high	high	ADJ
admet-2414	162	20	(	(	PUNCT
admet-2414	162	21	c	c	NOUN
admet-2414	162	22	)	)	PUNCT
admet-2414	162	23	.	.	PUNCT
admet-2414	163	1	the	the	DET
admet-2414	163	2	black	black	ADJ
admet-2414	163	3	line	line	NOUN
admet-2414	163	4	is	be	AUX
admet-2414	163	5	the	the	DET
admet-2414	163	6	exact	exact	ADJ
admet-2414	163	7	solution	solution	NOUN
admet-2414	163	8	(	(	PUNCT
admet-2414	163	9	equation	equation	NOUN
admet-2414	163	10	2	2	NUM
admet-2414	163	11	)	)	PUNCT
admet-2414	163	12	,	,	PUNCT
admet-2414	163	13	the	the	DET
admet-2414	163	14	red	red	ADJ
admet-2414	163	15	line	line	NOUN
admet-2414	163	16	is	be	AUX
admet-2414	163	17	the	the	DET
admet-2414	163	18	high	high	ADJ
admet-2414	163	19	concentration	concentration	NOUN
admet-2414	163	20	approximation	approximation	NOUN
admet-2414	163	21	(	(	PUNCT
admet-2414	163	22	equation	equation	NOUN
admet-2414	163	23	3	3	NUM
admet-2414	163	24	)	)	PUNCT
admet-2414	163	25	and	and	CCONJ
admet-2414	163	26	the	the	DET
admet-2414	163	27	blue	blue	ADJ
admet-2414	163	28	line	line	NOUN
admet-2414	163	29	is	be	AUX
admet-2414	163	30	the	the	DET
admet-2414	163	31	low	low	ADJ
admet-2414	163	32	concentration	concentration	NOUN
admet-2414	163	33	approximation	approximation	NOUN
admet-2414	163	34	(	(	PUNCT
admet-2414	163	35	equation	equation	NOUN
admet-2414	163	36	4	4	NUM
admet-2414	163	37	)	)	PUNCT
admet-2414	163	38	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	163	39	d.	d.	PROPN
admet-2414	163	40	g.	g.	PROPN
admet-2414	163	41	levitt	levitt	PROPN
admet-2414	163	42	admet	admet	PROPN
admet-2414	163	43	&	&	CCONJ
admet-2414	163	44	dmpk	dmpk	PROPN
admet-2414	163	45	12(6	12(6	NUM
admet-2414	163	46	)	)	PUNCT
admet-2414	163	47	(	(	PUNCT
admet-2414	163	48	2024	2024	NUM
admet-2414	163	49	)	)	PUNCT
admet-2414	163	50	971	971	NUM
admet-2414	163	51	-	-	SYM
admet-2414	163	52	989	989	NUM
admet-2414	163	53	978	978	NUM
admet-2414	163	54	time	time	NOUN
admet-2414	163	55	-	-	PUNCT
admet-2414	163	56	dependent	dependent	ADJ
admet-2414	163	57	model	model	NOUN
admet-2414	163	58	predictions	prediction	NOUN
admet-2414	163	59	for	for	ADP
admet-2414	163	60	dexamethasone	dexamethasone	NOUN
admet-2414	163	61	figure	figure	NOUN
admet-2414	163	62	5	5	NUM
admet-2414	163	63	shows	show	VERB
admet-2414	163	64	a	a	DET
admet-2414	163	65	plot	plot	NOUN
admet-2414	163	66	of	of	ADP
admet-2414	163	67	the	the	DET
admet-2414	163	68	time	time	NOUN
admet-2414	163	69	dependence	dependence	NOUN
admet-2414	163	70	(	(	PUNCT
admet-2414	163	71	see	see	VERB
admet-2414	163	72	supplement	supplement	NOUN
admet-2414	163	73	i	i	PRON
admet-2414	163	74	for	for	ADP
admet-2414	163	75	details	detail	NOUN
admet-2414	163	76	)	)	PUNCT
admet-2414	163	77	of	of	ADP
admet-2414	163	78	the	the	DET
admet-2414	163	79	fraction	fraction	NOUN
admet-2414	163	80	of	of	ADP
admet-2414	163	81	gr	gr	PRON
admet-2414	163	82	that	that	PRON
admet-2414	163	83	is	be	AUX
admet-2414	163	84	in	in	ADP
admet-2414	163	85	the	the	DET
admet-2414	163	86	rngn	rngn	NOUN
admet-2414	163	87	state	state	NOUN
admet-2414	163	88	after	after	ADP
admet-2414	163	89	the	the	DET
admet-2414	163	90	dex	dex	NOUN
admet-2414	163	91	concentration	concentration	NOUN
admet-2414	163	92	at	at	ADP
admet-2414	163	93	time	time	NOUN
admet-2414	163	94	=	=	SYM
admet-2414	163	95	0	0	NUM
admet-2414	163	96	is	be	AUX
admet-2414	163	97	suddenly	suddenly	ADV
admet-2414	163	98	raised	raise	VERB
admet-2414	163	99	from	from	ADP
admet-2414	163	100	0	0	NUM
admet-2414	163	101	to	to	ADP
admet-2414	163	102	0.1	0.1	NUM
admet-2414	163	103	nm	nm	NOUN
admet-2414	163	104	(	(	PUNCT
admet-2414	163	105	black	black	ADJ
admet-2414	163	106	line	line	NOUN
admet-2414	163	107	)	)	PUNCT
admet-2414	163	108	,	,	PUNCT
admet-2414	163	109	1	1	NUM
admet-2414	163	110	nm	nm	NOUN
admet-2414	163	111	(	(	PUNCT
admet-2414	163	112	red	red	PROPN
admet-2414	163	113	)	)	PUNCT
admet-2414	163	114	,	,	PUNCT
admet-2414	163	115	10	10	NUM
admet-2414	163	116	nm	nm	NOUN
admet-2414	163	117	(	(	PUNCT
admet-2414	163	118	green	green	ADJ
admet-2414	163	119	)	)	PUNCT
admet-2414	163	120	or	or	CCONJ
admet-2414	163	121	100	100	NUM
admet-2414	163	122	nm	nm	ADJ
admet-2414	163	123	(	(	PUNCT
admet-2414	163	124	blue	blue	ADJ
admet-2414	163	125	)	)	PUNCT
admet-2414	163	126	.	.	PUNCT
admet-2414	164	1	at	at	ADP
admet-2414	164	2	the	the	DET
admet-2414	164	3	low	low	ADJ
admet-2414	164	4	concentrations	concentration	NOUN
admet-2414	164	5	(	(	PUNCT
admet-2414	164	6	0.1	0.1	NUM
admet-2414	164	7	or	or	CCONJ
admet-2414	164	8	1	1	NUM
admet-2414	164	9	nm	nm	NOUN
admet-2414	164	10	)	)	PUNCT
admet-2414	164	11	,	,	PUNCT
admet-2414	164	12	there	there	PRON
admet-2414	164	13	is	be	VERB
admet-2414	164	14	a	a	DET
admet-2414	164	15	transient	transient	ADJ
admet-2414	164	16	spike	spike	NOUN
admet-2414	164	17	in	in	ADP
admet-2414	164	18	the	the	DET
admet-2414	164	19	rngn	rngn	NOUN
admet-2414	164	20	fraction	fraction	NOUN
admet-2414	164	21	as	as	ADP
admet-2414	164	22	the	the	DET
admet-2414	164	23	gr	gr	PROPN
admet-2414	164	24	cycles	cycle	NOUN
admet-2414	164	25	through	through	ADP
admet-2414	164	26	rngn	rngn	NOUN
admet-2414	164	27	(	(	PUNCT
admet-2414	164	28	see	see	VERB
admet-2414	164	29	figure	figure	NOUN
admet-2414	164	30	1	1	NUM
admet-2414	164	31	)	)	PUNCT
admet-2414	164	32	before	before	SCONJ
admet-2414	164	33	it	it	PRON
admet-2414	164	34	dissociates	dissociate	VERB
admet-2414	164	35	at	at	ADP
admet-2414	164	36	rate	rate	NOUN
admet-2414	164	37	=	=	SYM
admet-2414	164	38	k4	k4	NOUN
admet-2414	164	39	(	(	PUNCT
admet-2414	164	40	time	time	NOUN
admet-2414	164	41	constant	constant	ADJ
admet-2414	164	42	=	=	SYM
admet-2414	164	43	25	25	NUM
admet-2414	164	44	minutes	minute	NOUN
admet-2414	164	45	)	)	PUNCT
admet-2414	164	46	to	to	ADP
admet-2414	164	47	the	the	DET
admet-2414	164	48	free	free	ADJ
admet-2414	164	49	nuclear	nuclear	ADJ
admet-2414	164	50	receptor	receptor	NOUN
admet-2414	164	51	.	.	PUNCT
admet-2414	165	1	after	after	ADP
admet-2414	165	2	about	about	ADV
admet-2414	165	3	100	100	NUM
admet-2414	165	4	minutes	minute	NOUN
admet-2414	165	5	,	,	PUNCT
admet-2414	165	6	the	the	DET
admet-2414	165	7	fraction	fraction	NOUN
admet-2414	165	8	of	of	ADP
admet-2414	165	9	rngn	rngn	PROPN
admet-2414	165	10	settles	settle	VERB
admet-2414	165	11	down	down	ADP
admet-2414	165	12	to	to	ADP
admet-2414	165	13	the	the	DET
admet-2414	165	14	steady	steady	ADJ
admet-2414	165	15	-	-	PUNCT
admet-2414	165	16	state	state	NOUN
admet-2414	165	17	values	value	NOUN
admet-2414	165	18	described	describe	VERB
admet-2414	165	19	in	in	ADP
admet-2414	165	20	figure	figure	NOUN
admet-2414	165	21	3	3	NUM
admet-2414	165	22	.	.	PUNCT
admet-2414	166	1	although	although	SCONJ
admet-2414	166	2	this	this	DET
admet-2414	166	3	transient	transient	ADJ
admet-2414	166	4	spike	spike	NOUN
admet-2414	166	5	is	be	AUX
admet-2414	166	6	a	a	DET
admet-2414	166	7	novel	novel	ADJ
admet-2414	166	8	prediction	prediction	NOUN
admet-2414	166	9	of	of	ADP
admet-2414	166	10	the	the	DET
admet-2414	166	11	kinetic	kinetic	ADJ
admet-2414	166	12	model	model	NOUN
admet-2414	166	13	,	,	PUNCT
admet-2414	166	14	it	it	PRON
admet-2414	166	15	probably	probably	ADV
admet-2414	166	16	is	be	AUX
admet-2414	166	17	not	not	PART
admet-2414	166	18	clinically	clinically	ADV
admet-2414	166	19	significant	significant	ADJ
admet-2414	166	20	because	because	SCONJ
admet-2414	166	21	the	the	DET
admet-2414	166	22	time	time	NOUN
admet-2414	166	23	course	course	NOUN
admet-2414	166	24	of	of	ADP
admet-2414	166	25	the	the	DET
admet-2414	166	26	transcriptional	transcriptional	ADJ
admet-2414	166	27	modulation	modulation	NOUN
admet-2414	166	28	of	of	ADP
admet-2414	166	29	protein	protein	NOUN
admet-2414	166	30	synthesis	synthesis	NOUN
admet-2414	166	31	is	be	AUX
admet-2414	166	32	so	so	ADV
admet-2414	166	33	slow	slow	ADJ
admet-2414	166	34	(	(	PUNCT
admet-2414	166	35	five	five	NUM
admet-2414	166	36	or	or	CCONJ
admet-2414	166	37	more	more	ADJ
admet-2414	166	38	hours	hour	NOUN
admet-2414	166	39	[	[	X
admet-2414	166	40	33,34	33,34	NOUN
admet-2414	166	41	]	]	PUNCT
admet-2414	166	42	)	)	PUNCT
admet-2414	166	43	that	that	SCONJ
admet-2414	166	44	these	these	DET
admet-2414	166	45	short	short	ADJ
admet-2414	166	46	-	-	PUNCT
admet-2414	166	47	term	term	NOUN
admet-2414	166	48	spikes	spike	NOUN
admet-2414	166	49	should	should	AUX
admet-2414	166	50	be	be	AUX
admet-2414	166	51	averaged	average	VERB
admet-2414	166	52	out	out	ADP
admet-2414	166	53	.	.	PUNCT
admet-2414	167	1	figure	figure	NOUN
admet-2414	167	2	5	5	NUM
admet-2414	167	3	.	.	NOUN
admet-2414	167	4	time	time	NOUN
admet-2414	167	5	course	course	NOUN
admet-2414	167	6	of	of	ADP
admet-2414	167	7	the	the	DET
admet-2414	167	8	fraction	fraction	NOUN
admet-2414	167	9	of	of	ADP
admet-2414	167	10	gr	gr	NOUN
admet-2414	167	11	in	in	ADP
admet-2414	167	12	the	the	DET
admet-2414	167	13	transcriptional	transcriptional	NOUN
admet-2414	167	14	modifying	modify	VERB
admet-2414	167	15	state	state	NOUN
admet-2414	167	16	rngn	rngn	NOUN
admet-2414	167	17	as	as	ADP
admet-2414	167	18	a	a	DET
admet-2414	167	19	function	function	NOUN
admet-2414	167	20	of	of	ADP
admet-2414	167	21	time	time	NOUN
admet-2414	167	22	after	after	ADP
admet-2414	167	23	the	the	DET
admet-2414	167	24	addition	addition	NOUN
admet-2414	167	25	of	of	ADP
admet-2414	167	26	varying	vary	VERB
admet-2414	167	27	concentrations	concentration	NOUN
admet-2414	167	28	of	of	ADP
admet-2414	167	29	dex	dex	NOUN
admet-2414	167	30	an	an	DET
admet-2414	167	31	experimental	experimental	ADJ
admet-2414	167	32	check	check	NOUN
admet-2414	167	33	of	of	ADP
admet-2414	167	34	the	the	DET
admet-2414	167	35	model	model	NOUN
admet-2414	167	36	predictions	prediction	NOUN
admet-2414	167	37	is	be	AUX
admet-2414	167	38	provided	provide	VERB
admet-2414	167	39	by	by	ADP
admet-2414	167	40	the	the	DET
admet-2414	167	41	dex	dex	NOUN
admet-2414	167	42	dissociation	dissociation	NOUN
admet-2414	167	43	measurements	measurement	NOUN
admet-2414	167	44	of	of	ADP
admet-2414	167	45	meijsing	meijse	VERB
admet-2414	167	46	et	et	PROPN
admet-2414	167	47	al	al	PROPN
admet-2414	167	48	.	.	PUNCT
admet-2414	168	1	[	[	X
admet-2414	168	2	17	17	NUM
admet-2414	168	3	]	]	PUNCT
admet-2414	168	4	.	.	PUNCT
admet-2414	169	1	cells	cell	NOUN
admet-2414	169	2	were	be	AUX
admet-2414	169	3	equilibrated	equilibrate	VERB
admet-2414	169	4	with	with	ADP
admet-2414	169	5	100	100	NUM
admet-2414	169	6	nm	nm	NOUN
admet-2414	169	7	[	[	X
admet-2414	169	8	3h]dex	3h]dex	NUM
admet-2414	170	1	and	and	CCONJ
admet-2414	170	2	then	then	ADV
admet-2414	170	3	the	the	DET
admet-2414	170	4	time	time	NOUN
admet-2414	170	5	course	course	NOUN
admet-2414	170	6	of	of	ADP
admet-2414	170	7	hormone	hormone	NOUN
admet-2414	170	8	dissociation	dissociation	NOUN
admet-2414	170	9	from	from	ADP
admet-2414	170	10	gr	gr	PROPN
admet-2414	170	11	was	be	AUX
admet-2414	170	12	measured	measure	VERB
admet-2414	170	13	following	follow	VERB
admet-2414	170	14	a	a	DET
admet-2414	170	15	cold	cold	ADJ
admet-2414	170	16	chase	chase	NOUN
admet-2414	170	17	with	with	ADP
admet-2414	170	18	the	the	DET
admet-2414	170	19	addition	addition	NOUN
admet-2414	170	20	of	of	ADP
admet-2414	170	21	a	a	DET
admet-2414	170	22	200	200	NUM
admet-2414	170	23	-	-	ADJ
admet-2414	170	24	fold	fold	ADJ
admet-2414	170	25	excess	excess	NOUN
admet-2414	170	26	of	of	ADP
admet-2414	170	27	unlabeled	unlabeled	ADJ
admet-2414	170	28	dex	dex	NOUN
admet-2414	170	29	.	.	PUNCT
admet-2414	171	1	figure	figure	NOUN
admet-2414	171	2	6	6	NUM
admet-2414	171	3	shows	show	VERB
admet-2414	171	4	the	the	DET
admet-2414	171	5	model	model	NOUN
admet-2414	171	6	predictions	prediction	NOUN
admet-2414	171	7	for	for	ADP
admet-2414	171	8	these	these	DET
admet-2414	171	9	conditions	condition	NOUN
admet-2414	171	10	(	(	PUNCT
admet-2414	171	11	see	see	VERB
admet-2414	171	12	supplement	supplement	NOUN
admet-2414	171	13	i	i	PRON
admet-2414	171	14	for	for	ADP
admet-2414	171	15	details	detail	NOUN
admet-2414	171	16	)	)	PUNCT
admet-2414	171	17	.	.	PUNCT
admet-2414	172	1	figure	figure	VERB
admet-2414	172	2	6	6	NUM
admet-2414	172	3	.	.	NOUN
admet-2414	172	4	time	time	NOUN
admet-2414	172	5	course	course	NOUN
admet-2414	172	6	of	of	ADP
admet-2414	172	7	labeled	label	VERB
admet-2414	172	8	[	[	X
admet-2414	172	9	3h]dexamethasone	3h]dexamethasone	NUM
admet-2414	172	10	tightly	tightly	ADV
admet-2414	172	11	bound	bind	VERB
admet-2414	172	12	to	to	ADP
admet-2414	172	13	nuclear	nuclear	ADJ
admet-2414	172	14	gr	gr	NOUN
admet-2414	172	15	receptor	receptor	NOUN
admet-2414	172	16	following	follow	VERB
admet-2414	172	17	a	a	DET
admet-2414	172	18	cold	cold	ADJ
admet-2414	172	19	chase	chase	NOUN
admet-2414	172	20	with	with	ADP
admet-2414	172	21	a	a	DET
admet-2414	172	22	200	200	NUM
admet-2414	172	23	-	-	ADJ
admet-2414	172	24	fold	fold	ADJ
admet-2414	172	25	excess	excess	NOUN
admet-2414	172	26	of	of	ADP
admet-2414	172	27	unlabeled	unlabeled	ADJ
admet-2414	172	28	dexamethasone	dexamethasone	NOUN
admet-2414	172	29	.	.	PUNCT
admet-2414	173	1	at	at	ADP
admet-2414	173	2	time	time	NOUN
admet-2414	173	3	0	0	NUM
admet-2414	173	4	,	,	PUNCT
admet-2414	173	5	100	100	NUM
admet-2414	173	6	nm	nm	NOUN
admet-2414	173	7	[	[	X
admet-2414	173	8	3h]dexamethasone	3h]dexamethasone	NOUN
admet-2414	173	9	is	be	AUX
admet-2414	173	10	added	add	VERB
admet-2414	173	11	.	.	PUNCT
admet-2414	174	1	at	at	ADP
admet-2414	174	2	time	time	NOUN
admet-2414	174	3	of	of	ADP
admet-2414	174	4	100	100	NUM
admet-2414	174	5	minutes	minute	NOUN
admet-2414	174	6	,	,	PUNCT
admet-2414	174	7	20	20	NUM
admet-2414	174	8	mm	mm	NOUN
admet-2414	174	9	unlabeled	unlabele	VERB
admet-2414	174	10	dexamethasone	dexamethasone	NOUN
admet-2414	174	11	is	be	AUX
admet-2414	174	12	added	add	VERB
admet-2414	174	13	.	.	PUNCT
admet-2414	175	1	the	the	DET
admet-2414	175	2	fraction	fraction	NOUN
admet-2414	175	3	of	of	ADP
admet-2414	175	4	[	[	X
admet-2414	175	5	3h]dexamethasone	3h]dexamethasone	NUM
admet-2414	175	6	labeled	label	VERB
admet-2414	175	7	nuclear	nuclear	ADJ
admet-2414	175	8	receptor	receptor	NOUN
admet-2414	175	9	(	(	PUNCT
admet-2414	175	10	rng*t	rng*t	NOUN
admet-2414	175	11	+	+	CCONJ
admet-2414	175	12	rng*n	rng*n	NOUN
admet-2414	175	13	)	)	PUNCT
admet-2414	175	14	is	be	AUX
admet-2414	175	15	plotted	plot	VERB
admet-2414	175	16	as	as	ADP
admet-2414	175	17	a	a	DET
admet-2414	175	18	function	function	NOUN
admet-2414	175	19	of	of	ADP
admet-2414	175	20	time	time	NOUN
admet-2414	175	21	.	.	PUNCT
admet-2414	176	1	the	the	DET
admet-2414	176	2	solid	solid	ADJ
admet-2414	176	3	circles	circle	NOUN
admet-2414	176	4	are	be	AUX
admet-2414	176	5	the	the	DET
admet-2414	176	6	experimental	experimental	ADJ
admet-2414	176	7	data	datum	NOUN
admet-2414	176	8	of	of	ADP
admet-2414	176	9	meijsing	meijse	VERB
admet-2414	176	10	et	et	PROPN
admet-2414	176	11	.	.	PUNCT
admet-2414	177	1	al	al	PROPN
admet-2414	177	2	.	.	PUNCT
admet-2414	178	1	[	[	X
admet-2414	178	2	17	17	NUM
admet-2414	178	3	]	]	X
admet-2414	178	4	admet	admet	PROPN
admet-2414	178	5	&	&	CCONJ
admet-2414	178	6	dmpk	dmpk	PROPN
admet-2414	178	7	12(6	12(6	NUM
admet-2414	178	8	)	)	PUNCT
admet-2414	178	9	(	(	PUNCT
admet-2414	178	10	2024	2024	NUM
admet-2414	178	11	)	)	PUNCT
admet-2414	178	12	971	971	NUM
admet-2414	178	13	-	-	SYM
admet-2414	178	14	989	989	NUM
admet-2414	178	15	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	178	16	/	/	SYM
admet-2414	178	17	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	178	18	of	of	ADP
admet-2414	178	19	glucocorticoids	glucocorticoid	NOUN
admet-2414	178	20	doi	doi	NOUN
admet-2414	178	21	:	:	PUNCT
admet-2414	178	22	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	178	23	979	979	NUM
admet-2414	178	24	at	at	ADP
admet-2414	178	25	time	time	NOUN
admet-2414	178	26	0	0	NUM
admet-2414	178	27	,	,	PUNCT
admet-2414	178	28	100	100	NUM
admet-2414	178	29	nm	nm	NOUN
admet-2414	178	30	of	of	ADP
admet-2414	178	31	labeled	label	VERB
admet-2414	178	32	dex	dex	NOUN
admet-2414	178	33	(	(	PUNCT
admet-2414	178	34	g	g	NOUN
admet-2414	178	35	*	*	PUNCT
admet-2414	178	36	)	)	PUNCT
admet-2414	178	37	is	be	AUX
admet-2414	178	38	added	add	VERB
admet-2414	178	39	and	and	CCONJ
admet-2414	178	40	then	then	ADV
admet-2414	178	41	,	,	PUNCT
admet-2414	178	42	after	after	SCONJ
admet-2414	178	43	a	a	DET
admet-2414	178	44	steady	steady	ADJ
admet-2414	178	45	state	state	NOUN
admet-2414	178	46	is	be	AUX
admet-2414	178	47	reached	reach	VERB
admet-2414	178	48	at	at	ADP
admet-2414	178	49	100	100	NUM
admet-2414	178	50	minutes	minute	NOUN
admet-2414	178	51	,	,	PUNCT
admet-2414	178	52	20	20	NUM
admet-2414	178	53	mm	mm	NOUN
admet-2414	178	54	of	of	ADP
admet-2414	178	55	unlabeled	unlabeled	ADJ
admet-2414	178	56	dex	dex	NOUN
admet-2414	178	57	is	be	AUX
admet-2414	178	58	added	add	VERB
admet-2414	178	59	,	,	PUNCT
admet-2414	178	60	and	and	CCONJ
admet-2414	178	61	the	the	DET
admet-2414	178	62	fraction	fraction	NOUN
admet-2414	178	63	of	of	ADP
admet-2414	178	64	the	the	DET
admet-2414	178	65	labeled	label	VERB
admet-2414	178	66	dex	dex	NOUN
admet-2414	178	67	tightly	tightly	ADV
admet-2414	178	68	bound	bind	VERB
admet-2414	178	69	to	to	ADP
admet-2414	178	70	nuclear	nuclear	ADJ
admet-2414	178	71	gr	gr	NOUN
admet-2414	178	72	receptor	receptor	NOUN
admet-2414	178	73	(=	(=	AUX
admet-2414	178	74	rng*t	rng*t	VERB
admet-2414	178	75	+	+	CCONJ
admet-2414	179	1	rng*n	rng*n	NOUN
admet-2414	179	2	)	)	PUNCT
admet-2414	179	3	is	be	AUX
admet-2414	179	4	plotted	plot	VERB
admet-2414	179	5	.	.	PUNCT
admet-2414	180	1	the	the	DET
admet-2414	180	2	model	model	NOUN
admet-2414	180	3	predictions	prediction	NOUN
admet-2414	180	4	are	be	AUX
admet-2414	180	5	in	in	ADP
admet-2414	180	6	good	good	ADJ
admet-2414	180	7	agreement	agreement	NOUN
admet-2414	180	8	with	with	ADP
admet-2414	180	9	the	the	DET
admet-2414	180	10	experimental	experimental	ADJ
admet-2414	180	11	results	result	NOUN
admet-2414	180	12	of	of	ADP
admet-2414	180	13	meijsing	meijse	VERB
admet-2414	180	14	et	et	PROPN
admet-2414	180	15	al	al	PROPN
admet-2414	180	16	.	.	PUNCT
admet-2414	181	1	(	(	PUNCT
admet-2414	181	2	red	red	ADJ
admet-2414	181	3	solid	solid	ADJ
admet-2414	181	4	circles	circle	NOUN
admet-2414	181	5	)	)	PUNCT
admet-2414	182	1	[	[	X
admet-2414	182	2	17	17	NUM
admet-2414	182	3	]	]	PUNCT
admet-2414	182	4	.	.	PUNCT
admet-2414	183	1	the	the	DET
admet-2414	183	2	glucocorticoid	glucocorticoid	ADJ
admet-2414	183	3	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	183	4	of	of	ADP
admet-2414	183	5	endogenous	endogenous	ADJ
admet-2414	183	6	cortisol	cortisol	NOUN
admet-2414	183	7	and	and	CCONJ
admet-2414	183	8	varying	vary	VERB
admet-2414	183	9	doses	dose	NOUN
admet-2414	183	10	of	of	ADP
admet-2414	183	11	dexamethasone	dexamethasone	NOUN
admet-2414	183	12	,	,	PUNCT
admet-2414	183	13	methylprednisolone	methylprednisolone	NOUN
admet-2414	183	14	and	and	CCONJ
admet-2414	183	15	prednisone	prednisone	NOUN
admet-2414	183	16	the	the	DET
admet-2414	183	17	gr	gr	PROPN
admet-2414	183	18	nuclear	nuclear	ADJ
admet-2414	183	19	transcriptional	transcriptional	NOUN
admet-2414	183	20	rate	rate	NOUN
admet-2414	183	21	will	will	AUX
admet-2414	183	22	first	first	ADV
admet-2414	183	23	be	be	AUX
admet-2414	183	24	estimated	estimate	VERB
admet-2414	183	25	for	for	ADP
admet-2414	183	26	the	the	DET
admet-2414	183	27	normal	normal	ADJ
admet-2414	183	28	human	human	ADJ
admet-2414	183	29	endogenous	endogenous	ADJ
admet-2414	183	30	diurnal	diurnal	ADJ
admet-2414	183	31	24	24	NUM
admet-2414	183	32	-	-	PUNCT
admet-2414	183	33	hour	hour	NOUN
admet-2414	183	34	free	free	ADJ
admet-2414	183	35	plasma	plasma	NOUN
admet-2414	183	36	cortisol	cortisol	NOUN
admet-2414	183	37	concentration	concentration	NOUN
admet-2414	183	38	.	.	PUNCT
admet-2414	184	1	this	this	DET
admet-2414	184	2	basal	basal	ADJ
admet-2414	184	3	activity	activity	NOUN
admet-2414	184	4	will	will	AUX
admet-2414	184	5	then	then	ADV
admet-2414	184	6	serve	serve	VERB
admet-2414	184	7	as	as	ADP
admet-2414	184	8	a	a	DET
admet-2414	184	9	reference	reference	NOUN
admet-2414	184	10	for	for	ADP
admet-2414	184	11	the	the	DET
admet-2414	184	12	common	common	ADJ
admet-2414	184	13	clinically	clinically	ADV
admet-2414	184	14	used	use	VERB
admet-2414	184	15	glucocorticoids	glucocorticoid	NOUN
admet-2414	184	16	.	.	PUNCT
admet-2414	185	1	at	at	ADP
admet-2414	185	2	high	high	ADJ
admet-2414	185	3	plasma	plasma	NOUN
admet-2414	185	4	g	g	NOUN
admet-2414	185	5	concentrations	concentration	NOUN
admet-2414	185	6	,	,	PUNCT
admet-2414	185	7	the	the	DET
admet-2414	185	8	details	detail	NOUN
admet-2414	185	9	of	of	ADP
admet-2414	185	10	the	the	DET
admet-2414	185	11	above	above	ADJ
admet-2414	185	12	gr	gr	NOUN
admet-2414	185	13	model	model	NOUN
admet-2414	185	14	can	can	AUX
admet-2414	185	15	be	be	AUX
admet-2414	185	16	ignored	ignore	VERB
admet-2414	185	17	and	and	CCONJ
admet-2414	185	18	one	one	PRON
admet-2414	185	19	can	can	AUX
admet-2414	185	20	simply	simply	ADV
admet-2414	185	21	use	use	VERB
admet-2414	185	22	the	the	DET
admet-2414	185	23	experimental	experimental	ADJ
admet-2414	185	24	steady	steady	ADJ
admet-2414	185	25	state	state	NOUN
admet-2414	185	26	michaelis	michaelis	PROPN
admet-2414	185	27	-	-	PUNCT
admet-2414	185	28	menton	menton	PROPN
admet-2414	185	29	relation	relation	PROPN
admet-2414	185	30	(	(	PUNCT
admet-2414	185	31	equation	equation	NOUN
admet-2414	185	32	(	(	PUNCT
admet-2414	185	33	1	1	NUM
admet-2414	185	34	)	)	PUNCT
admet-2414	185	35	)	)	PUNCT
admet-2414	186	1	whose	whose	DET
admet-2414	186	2	affinity	affinity	NOUN
admet-2414	186	3	is	be	AUX
admet-2414	186	4	characterized	characterize	VERB
admet-2414	186	5	by	by	ADP
admet-2414	186	6	the	the	DET
admet-2414	186	7	parameter	parameter	PROPN
admet-2414	186	8	kmt	kmt	PROPN
admet-2414	186	9	(=	(=	ADP
admet-2414	186	10	kmh	kmh	PROPN
admet-2414	186	11	)	)	PUNCT
admet-2414	186	12	which	which	PRON
admet-2414	186	13	is	be	AUX
admet-2414	186	14	equal	equal	ADJ
admet-2414	186	15	to	to	ADP
admet-2414	186	16	the	the	DET
admet-2414	186	17	experimental	experimental	ADJ
admet-2414	186	18	ec50	ec50	PROPN
admet-2414	186	19	(	(	PUNCT
admet-2414	186	20	or	or	CCONJ
admet-2414	186	21	ic50	ic50	PROPN
admet-2414	186	22	for	for	ADP
admet-2414	186	23	an	an	DET
admet-2414	186	24	inhibitory	inhibitory	ADJ
admet-2414	186	25	effect	effect	NOUN
admet-2414	186	26	)	)	PUNCT
admet-2414	186	27	of	of	ADP
admet-2414	186	28	the	the	DET
admet-2414	186	29	gr	gr	ADJ
admet-2414	186	30	cellular	cellular	ADJ
admet-2414	186	31	response	response	NOUN
admet-2414	186	32	.	.	PUNCT
admet-2414	187	1	however	however	ADV
admet-2414	187	2	,	,	PUNCT
admet-2414	187	3	this	this	DET
admet-2414	187	4	equation	equation	NOUN
admet-2414	187	5	is	be	AUX
admet-2414	187	6	not	not	PART
admet-2414	187	7	valid	valid	ADJ
admet-2414	187	8	at	at	ADP
admet-2414	187	9	low	low	ADJ
admet-2414	187	10	concentrations	concentration	NOUN
admet-2414	187	11	where	where	SCONJ
admet-2414	187	12	,	,	PUNCT
admet-2414	187	13	as	as	SCONJ
admet-2414	187	14	discussed	discuss	VERB
admet-2414	187	15	above	above	ADV
admet-2414	187	16	,	,	PUNCT
admet-2414	187	17	the	the	DET
admet-2414	187	18	affinity	affinity	NOUN
admet-2414	187	19	may	may	AUX
admet-2414	187	20	increase	increase	VERB
admet-2414	187	21	more	more	ADJ
admet-2414	187	22	than	than	ADP
admet-2414	187	23	1000	1000	NUM
admet-2414	187	24	-	-	NUM
admet-2414	187	25	fold	fold	ADJ
admet-2414	187	26	and	and	CCONJ
admet-2414	187	27	the	the	DET
admet-2414	187	28	exact	exact	ADJ
admet-2414	187	29	model	model	NOUN
admet-2414	187	30	result	result	NOUN
admet-2414	187	31	(	(	PUNCT
admet-2414	187	32	equation	equation	NOUN
admet-2414	187	33	(	(	PUNCT
admet-2414	187	34	2	2	X
admet-2414	187	35	)	)	PUNCT
admet-2414	187	36	must	must	AUX
admet-2414	187	37	be	be	AUX
admet-2414	187	38	used	use	VERB
admet-2414	187	39	.	.	PUNCT
admet-2414	188	1	this	this	PRON
admet-2414	188	2	is	be	AUX
admet-2414	188	3	quantitatively	quantitatively	ADV
admet-2414	188	4	illustrated	illustrate	VERB
admet-2414	188	5	in	in	ADP
admet-2414	188	6	the	the	DET
admet-2414	188	7	following	follow	VERB
admet-2414	188	8	discussion	discussion	NOUN
admet-2414	188	9	.	.	PUNCT
admet-2414	189	1	the	the	DET
admet-2414	189	2	best	well	ADV
admet-2414	189	3	defined	define	VERB
admet-2414	189	4	ec50	ec50	PROPN
admet-2414	189	5	measurements	measurement	NOUN
admet-2414	189	6	are	be	AUX
admet-2414	189	7	from	from	ADP
admet-2414	189	8	experiments	experiment	NOUN
admet-2414	189	9	in	in	ADP
admet-2414	189	10	which	which	PRON
admet-2414	189	11	a	a	DET
admet-2414	189	12	well	well	ADV
admet-2414	189	13	-	-	PUNCT
admet-2414	189	14	defined	define	VERB
admet-2414	189	15	cultured	cultured	ADJ
admet-2414	189	16	cell	cell	NOUN
admet-2414	189	17	line	line	NOUN
admet-2414	189	18	is	be	AUX
admet-2414	189	19	transfected	transfecte	VERB
admet-2414	189	20	with	with	ADP
admet-2414	189	21	a	a	DET
admet-2414	189	22	specific	specific	ADJ
admet-2414	189	23	gle	gle	NOUN
admet-2414	189	24	reporter	reporter	NOUN
admet-2414	189	25	gene	gene	NOUN
admet-2414	189	26	(	(	PUNCT
admet-2414	189	27	e.g.	e.g.	ADV
admet-2414	189	28	,	,	PUNCT
admet-2414	189	29	luciferase	luciferase	ADJ
admet-2414	189	30	)	)	PUNCT
admet-2414	189	31	,	,	PUNCT
admet-2414	189	32	and	and	CCONJ
admet-2414	189	33	the	the	DET
admet-2414	189	34	rate	rate	NOUN
admet-2414	189	35	of	of	ADP
admet-2414	189	36	production	production	NOUN
admet-2414	189	37	of	of	ADP
admet-2414	189	38	the	the	DET
admet-2414	189	39	transcription	transcription	NOUN
admet-2414	189	40	product	product	NOUN
admet-2414	189	41	is	be	AUX
admet-2414	189	42	measured	measure	VERB
admet-2414	189	43	(	(	PUNCT
admet-2414	189	44	with	with	ADP
admet-2414	189	45	an	an	DET
admet-2414	189	46	allowance	allowance	NOUN
admet-2414	189	47	for	for	ADP
admet-2414	189	48	a	a	DET
admet-2414	189	49	delayed	delay	VERB
admet-2414	189	50	response	response	NOUN
admet-2414	189	51	)	)	PUNCT
admet-2414	189	52	as	as	ADP
admet-2414	189	53	a	a	DET
admet-2414	189	54	function	function	NOUN
admet-2414	189	55	of	of	ADP
admet-2414	189	56	the	the	DET
admet-2414	189	57	free	free	ADJ
admet-2414	189	58	(	(	PUNCT
admet-2414	189	59	unbound	unbound	ADJ
admet-2414	189	60	)	)	PUNCT
admet-2414	189	61	glucocorticoid	glucocorticoid	ADJ
admet-2414	189	62	concentration	concentration	NOUN
admet-2414	189	63	in	in	ADP
admet-2414	189	64	the	the	DET
admet-2414	189	65	cell	cell	NOUN
admet-2414	189	66	culture	culture	NOUN
admet-2414	189	67	medium	medium	NOUN
admet-2414	189	68	.	.	PUNCT
admet-2414	190	1	there	there	PRON
admet-2414	190	2	have	have	AUX
admet-2414	190	3	been	be	AUX
admet-2414	190	4	many	many	ADJ
admet-2414	190	5	such	such	ADJ
admet-2414	190	6	measurements	measurement	NOUN
admet-2414	190	7	for	for	ADP
admet-2414	190	8	cortisol	cortisol	NOUN
admet-2414	190	9	,	,	PUNCT
admet-2414	190	10	dex	dex	NOUN
admet-2414	190	11	,	,	PUNCT
admet-2414	190	12	mp	mp	PROPN
admet-2414	190	13	and	and	CCONJ
admet-2414	190	14	prednisolone	prednisolone	PROPN
admet-2414	190	15	,	,	PUNCT
admet-2414	190	16	summarized	summarize	VERB
admet-2414	190	17	in	in	ADP
admet-2414	190	18	table	table	NOUN
admet-2414	190	19	2	2	NUM
admet-2414	190	20	.	.	PUNCT
admet-2414	191	1	the	the	DET
admet-2414	191	2	second	second	ADJ
admet-2414	191	3	column	column	NOUN
admet-2414	191	4	in	in	ADP
admet-2414	191	5	table	table	NOUN
admet-2414	191	6	2	2	NUM
admet-2414	191	7	lists	list	VERB
admet-2414	191	8	the	the	DET
admet-2414	191	9	absolute	absolute	ADJ
admet-2414	191	10	value	value	NOUN
admet-2414	191	11	of	of	ADP
admet-2414	191	12	the	the	DET
admet-2414	191	13	dex	dex	PROPN
admet-2414	191	14	kmt	kmt	PROPN
admet-2414	191	15	,	,	PUNCT
admet-2414	191	16	while	while	SCONJ
admet-2414	191	17	the	the	DET
admet-2414	191	18	kmt	kmt	PROPN
admet-2414	191	19	for	for	ADP
admet-2414	191	20	the	the	DET
admet-2414	191	21	other	other	ADJ
admet-2414	191	22	glucocorticoids	glucocorticoid	NOUN
admet-2414	191	23	are	be	AUX
admet-2414	191	24	expressed	express	VERB
admet-2414	191	25	relative	relative	ADJ
admet-2414	191	26	to	to	ADP
admet-2414	191	27	that	that	PRON
admet-2414	191	28	of	of	ADP
admet-2414	191	29	dexamethasone	dexamethasone	NOUN
admet-2414	191	30	.	.	PUNCT
admet-2414	192	1	each	each	DET
admet-2414	192	2	row	row	NOUN
admet-2414	192	3	corresponds	correspond	VERB
admet-2414	192	4	to	to	ADP
admet-2414	192	5	a	a	DET
admet-2414	192	6	different	different	ADJ
admet-2414	192	7	cell	cell	NOUN
admet-2414	192	8	line	line	NOUN
admet-2414	192	9	.	.	PUNCT
admet-2414	193	1	for	for	ADP
admet-2414	193	2	comparison	comparison	NOUN
admet-2414	193	3	,	,	PUNCT
admet-2414	193	4	the	the	DET
admet-2414	193	5	last	last	ADJ
admet-2414	193	6	row	row	NOUN
admet-2414	193	7	(	(	PUNCT
admet-2414	193	8	goodman	goodman	PROPN
admet-2414	193	9	and	and	CCONJ
admet-2414	193	10	gillman	gillman	PROPN
admet-2414	194	1	[	[	X
admet-2414	194	2	35	35	NUM
admet-2414	194	3	]	]	PUNCT
admet-2414	194	4	)	)	PUNCT
admet-2414	194	5	lists	list	VERB
admet-2414	194	6	the	the	DET
admet-2414	194	7	approximate	approximate	ADJ
admet-2414	194	8	relative	relative	ADJ
admet-2414	194	9	potency	potency	NOUN
admet-2414	194	10	for	for	ADP
admet-2414	194	11	the	the	DET
admet-2414	194	12	human	human	ADJ
admet-2414	194	13	clinical	clinical	ADJ
admet-2414	194	14	response	response	NOUN
admet-2414	194	15	.	.	PUNCT
admet-2414	195	1	table	table	NOUN
admet-2414	195	2	2	2	NUM
admet-2414	195	3	.	.	PUNCT
admet-2414	195	4	cell	cell	NOUN
admet-2414	195	5	culture	culture	NOUN
admet-2414	195	6	kmt	kmt	PROPN
admet-2414	195	7	values	value	NOUN
admet-2414	195	8	for	for	ADP
admet-2414	195	9	selected	select	VERB
admet-2414	195	10	glucocorticoids	glucocorticoid	NOUN
admet-2414	195	11	cell	cell	NOUN
admet-2414	195	12	line	line	NOUN
admet-2414	195	13	kmt	kmt	PROPN
admet-2414	195	14	/	/	PUNCT
admet-2414	195	15	nm	nm	PROPN
admet-2414	195	16	(	(	PUNCT
admet-2414	195	17	dexamethasone	dexamethasone	NOUN
admet-2414	195	18	)	)	PUNCT
admet-2414	195	19	kmt	kmt	PROPN
admet-2414	195	20	(	(	PUNCT
admet-2414	195	21	relative	relative	ADJ
admet-2414	195	22	to	to	ADP
admet-2414	195	23	dexamethasone	dexamethasone	NOUN
admet-2414	195	24	)	)	PUNCT
admet-2414	195	25	ref	ref	NOUN
admet-2414	195	26	.	.	PUNCT
admet-2414	196	1	cortisol	cortisol	PROPN
admet-2414	196	2	methylprednisolone	methylprednisolone	PROPN
admet-2414	196	3	prednisolone	prednisolone	PROPN
admet-2414	196	4	az	az	PROPN
admet-2414	196	5	-	-	PROPN
admet-2414	196	6	gr	gr	PROPN
admet-2414	196	7	9.55	9.55	NUM
admet-2414	196	8	6.91	6.91	NUM
admet-2414	196	9	3.16	3.16	NUM
admet-2414	196	10	4.67	4.67	NUM
admet-2414	196	11	[	[	X
admet-2414	196	12	30	30	NUM
admet-2414	196	13	]	]	X
admet-2414	196	14	hela	hela	PROPN
admet-2414	197	1	12	12	NUM
admet-2414	197	2	11	11	NUM
admet-2414	197	3	3.33	3.33	NUM
admet-2414	197	4	3.33	3.33	NUM
admet-2414	197	5	[	[	X
admet-2414	197	6	36	36	NUM
admet-2414	197	7	]	]	PUNCT
admet-2414	197	8	a549	a549	PROPN
admet-2414	197	9	10	10	NUM
admet-2414	197	10	15	15	NUM
admet-2414	197	11	4	4	NUM
admet-2414	197	12	7	7	NUM
admet-2414	197	13	htc	htc	NOUN
admet-2414	197	14	4	4	NUM
admet-2414	197	15	15	15	NUM
admet-2414	197	16	5	5	NUM
admet-2414	197	17	5	5	NUM
admet-2414	197	18	gr	gr	NUM
admet-2414	197	19	-	-	PUNCT
admet-2414	197	20	lbd	lbd	NOUN
admet-2414	197	21	0.154	0.154	NUM
admet-2414	197	22	30.9	30.9	NUM
admet-2414	197	23	2.87	2.87	NUM
admet-2414	197	24	[	[	X
admet-2414	197	25	37	37	NUM
admet-2414	197	26	]	]	PUNCT
admet-2414	197	27	pbmc	pbmc	NOUN
admet-2414	197	28	4.1	4.1	NUM
admet-2414	197	29	3.36	3.36	NUM
admet-2414	197	30	21	21	NUM
admet-2414	197	31	[	[	X
admet-2414	197	32	38	38	NUM
admet-2414	197	33	]	]	SYM
admet-2414	197	34	ccl-202	ccl-202	NOUN
admet-2414	197	35	0.5	0.5	NUM
admet-2414	197	36	20	20	NUM
admet-2414	197	37	10	10	NUM
admet-2414	198	1	[	[	X
admet-2414	198	2	39	39	NUM
admet-2414	198	3	]	]	PUNCT
admet-2414	198	4	gr/3xgre	gr/3xgre	VERB
admet-2414	198	5	1.66	1.66	NUM
admet-2414	198	6	27.5	27.5	NUM
admet-2414	198	7	[	[	X
admet-2414	198	8	40	40	NUM
admet-2414	198	9	]	]	SYM
admet-2414	198	10	gr	gr	PROPN
admet-2414	198	11	/	/	SYM
admet-2414	198	12	mmtv	mmtv	NOUN
admet-2414	198	13	1.02	1.02	NUM
admet-2414	198	14	58.9	58.9	NUM
admet-2414	198	15	gr	gr	PROPN
admet-2414	198	16	-	-	PUNCT
admet-2414	198	17	lbd	lbd	NOUN
admet-2414	198	18	0.83	0.83	NUM
admet-2414	198	19	72.4	72.4	NUM
admet-2414	198	20	clone	clone	NOUN
admet-2414	198	21	#	#	SYM
admet-2414	198	22	1	1	NUM
admet-2414	198	23	2.82	2.82	NUM
admet-2414	198	24	5.37	5.37	NUM
admet-2414	198	25	[	[	SYM
admet-2414	198	26	28	28	NUM
admet-2414	198	27	]	]	X
admet-2414	198	28	clone	clone	NOUN
admet-2414	198	29	#	#	SYM
admet-2414	198	30	5	5	NUM
admet-2414	198	31	5.89	5.89	NUM
admet-2414	198	32	4.79	4.79	NUM
admet-2414	198	33	clone	clone	NOUN
admet-2414	198	34	#	#	SYM
admet-2414	198	35	6	6	NUM
admet-2414	198	36	8.71	8.71	NUM
admet-2414	198	37	3.98	3.98	NUM
admet-2414	198	38	a549	a549	PROPN
admet-2414	198	39	1	1	NUM
admet-2414	198	40	10	10	NUM
admet-2414	198	41	hepatocytes	hepatocyte	NOUN
admet-2414	198	42	10	10	NUM
admet-2414	198	43	[	[	X
admet-2414	198	44	31	31	NUM
admet-2414	198	45	]	]	X
admet-2414	198	46	gr(wt	gr(wt	PROPN
admet-2414	198	47	)	)	PUNCT
admet-2414	198	48	0.5	0.5	NUM
admet-2414	198	49	gr(er22	gr(er22	NOUN
admet-2414	198	50	)	)	PUNCT
admet-2414	198	51	8	8	NUM
admet-2414	199	1	ar42	ar42	PROPN
admet-2414	199	2	10	10	NUM
admet-2414	199	3	human	human	ADJ
admet-2414	199	4	clinical	clinical	ADJ
admet-2414	199	5	response	response	NOUN
admet-2414	199	6	25	25	NUM
admet-2414	199	7	5	5	NUM
admet-2414	199	8	6.25	6.25	NUM
admet-2414	199	9	[	[	NOUN
admet-2414	199	10	35	35	NUM
admet-2414	199	11	]	]	PUNCT
admet-2414	199	12	considering	consider	VERB
admet-2414	199	13	that	that	SCONJ
admet-2414	199	14	these	these	DET
admet-2414	199	15	clinical	clinical	ADJ
admet-2414	199	16	results	result	NOUN
admet-2414	199	17	include	include	VERB
admet-2414	199	18	pharmacokinetic	pharmacokinetic	ADJ
admet-2414	199	19	factors	factor	NOUN
admet-2414	199	20	such	such	ADJ
admet-2414	199	21	as	as	ADP
admet-2414	199	22	oral	oral	ADJ
admet-2414	199	23	absorption	absorption	NOUN
admet-2414	199	24	,	,	PUNCT
admet-2414	199	25	metabolic	metabolic	NOUN
admet-2414	199	26	rates	rate	NOUN
admet-2414	199	27	,	,	PUNCT
admet-2414	199	28	volume	volume	NOUN
admet-2414	199	29	of	of	ADP
admet-2414	199	30	distribution	distribution	NOUN
admet-2414	199	31	,	,	PUNCT
admet-2414	199	32	etc	etc	X
admet-2414	199	33	.	.	X
admet-2414	199	34	,	,	PUNCT
admet-2414	199	35	they	they	PRON
admet-2414	199	36	are	be	AUX
admet-2414	199	37	surprisingly	surprisingly	ADV
admet-2414	199	38	similar	similar	ADJ
admet-2414	199	39	to	to	ADP
admet-2414	199	40	the	the	DET
admet-2414	199	41	cell	cell	NOUN
admet-2414	199	42	culture	culture	NOUN
admet-2414	199	43	results	result	NOUN
admet-2414	199	44	.	.	PUNCT
admet-2414	200	1	for	for	ADP
admet-2414	200	2	a	a	DET
admet-2414	200	3	given	give	VERB
admet-2414	200	4	glucocorticoid	glucocorticoid	NOUN
admet-2414	200	5	,	,	PUNCT
admet-2414	200	6	there	there	PRON
admet-2414	200	7	is	be	VERB
admet-2414	200	8	as	as	ADV
admet-2414	200	9	much	much	ADJ
admet-2414	200	10	as	as	ADP
admet-2414	200	11	a	a	DET
admet-2414	200	12	10	10	NUM
admet-2414	200	13	-	-	ADJ
admet-2414	200	14	fold	fold	ADJ
admet-2414	200	15	variation	variation	NOUN
admet-2414	200	16	of	of	ADP
admet-2414	200	17	kmt	kmt	PROPN
admet-2414	200	18	,	,	PUNCT
admet-2414	200	19	depending	depend	VERB
admet-2414	200	20	on	on	ADP
admet-2414	200	21	the	the	DET
admet-2414	200	22	cell	cell	NOUN
admet-2414	200	23	line	line	NOUN
admet-2414	200	24	.	.	PUNCT
admet-2414	201	1	this	this	PRON
admet-2414	201	2	suggests	suggest	VERB
admet-2414	201	3	that	that	SCONJ
admet-2414	201	4	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	201	5	d.	d.	PROPN
admet-2414	201	6	g.	g.	PROPN
admet-2414	201	7	levitt	levitt	PROPN
admet-2414	201	8	admet	admet	PROPN
admet-2414	201	9	&	&	CCONJ
admet-2414	201	10	dmpk	dmpk	PROPN
admet-2414	201	11	12(6	12(6	NUM
admet-2414	201	12	)	)	PUNCT
admet-2414	201	13	(	(	PUNCT
admet-2414	201	14	2024	2024	NUM
admet-2414	201	15	)	)	PUNCT
admet-2414	201	16	971	971	NUM
admet-2414	201	17	-	-	SYM
admet-2414	201	18	989	989	NUM
admet-2414	201	19	980	980	NUM
admet-2414	201	20	it	it	PRON
admet-2414	201	21	is	be	AUX
admet-2414	201	22	not	not	PART
admet-2414	201	23	appropriate	appropriate	ADJ
admet-2414	201	24	to	to	PART
admet-2414	201	25	assume	assume	VERB
admet-2414	201	26	a	a	DET
admet-2414	201	27	single	single	ADJ
admet-2414	201	28	value	value	NOUN
admet-2414	201	29	of	of	ADP
admet-2414	201	30	kmt	kmt	PROPN
admet-2414	201	31	for	for	ADP
admet-2414	201	32	the	the	DET
admet-2414	201	33	human	human	ADJ
admet-2414	201	34	glucocorticoid	glucocorticoid	ADJ
admet-2414	201	35	response	response	NOUN
admet-2414	201	36	which	which	PRON
admet-2414	201	37	,	,	PUNCT
admet-2414	201	38	presumably	presumably	ADV
admet-2414	201	39	,	,	PUNCT
admet-2414	201	40	involves	involve	VERB
admet-2414	201	41	a	a	DET
admet-2414	201	42	number	number	NOUN
admet-2414	201	43	of	of	ADP
admet-2414	201	44	different	different	ADJ
admet-2414	201	45	cell	cell	NOUN
admet-2414	201	46	types	type	NOUN
admet-2414	201	47	.	.	PUNCT
admet-2414	202	1	a	a	DET
admet-2414	202	2	“	"	PUNCT
admet-2414	202	3	representative	representative	NOUN
admet-2414	202	4	”	"	PUNCT
admet-2414	202	5	set	set	NOUN
admet-2414	202	6	of	of	ADP
admet-2414	202	7	kmt	kmt	PROPN
admet-2414	202	8	values	value	NOUN
admet-2414	202	9	was	be	AUX
admet-2414	202	10	assumed	assume	VERB
admet-2414	202	11	(	(	PUNCT
admet-2414	202	12	table	table	NOUN
admet-2414	202	13	3	3	NUM
admet-2414	202	14	)	)	PUNCT
admet-2414	202	15	,	,	PUNCT
admet-2414	202	16	with	with	ADP
admet-2414	202	17	the	the	DET
admet-2414	202	18	understanding	understanding	NOUN
admet-2414	202	19	that	that	PRON
admet-2414	202	20	these	these	DET
admet-2414	202	21	values	value	NOUN
admet-2414	202	22	are	be	AUX
admet-2414	202	23	only	only	ADV
admet-2414	202	24	rough	rough	ADJ
admet-2414	202	25	estimates	estimate	NOUN
admet-2414	202	26	.	.	PUNCT
admet-2414	203	1	the	the	DET
admet-2414	203	2	uncertainty	uncertainty	NOUN
admet-2414	203	3	in	in	ADP
admet-2414	203	4	the	the	DET
admet-2414	203	5	predicted	predict	VERB
admet-2414	203	6	model	model	NOUN
admet-2414	203	7	concentration	concentration	NOUN
admet-2414	203	8	dependence	dependence	NOUN
admet-2414	203	9	is	be	AUX
admet-2414	203	10	roughly	roughly	ADV
admet-2414	203	11	proportional	proportional	ADJ
admet-2414	203	12	to	to	ADP
admet-2414	203	13	this	this	DET
admet-2414	203	14	variation	variation	NOUN
admet-2414	203	15	in	in	ADP
admet-2414	203	16	kmt	kmt	PROPN
admet-2414	203	17	.	.	PUNCT
admet-2414	204	1	table	table	NOUN
admet-2414	204	2	3	3	NUM
admet-2414	204	3	.	.	PUNCT
admet-2414	204	4	assumed	assume	VERB
admet-2414	204	5	representative	representative	ADJ
admet-2414	204	6	glucocorticoid	glucocorticoid	ADJ
admet-2414	204	7	model	model	NOUN
admet-2414	204	8	affinity	affinity	NOUN
admet-2414	204	9	parameters	parameter	NOUN
admet-2414	204	10	kmh	kmh	PROPN
admet-2414	204	11	=	=	PUNCT
admet-2414	204	12	kmt	kmt	PROPN
admet-2414	204	13	/	/	SYM
admet-2414	204	14	nm	nm	PROPN
admet-2414	204	15	kn	kn	PROPN
admet-2414	204	16	/	/	PUNCT
admet-2414	204	17	nm	nm	PROPN
admet-2414	204	18	kc	kc	PROPN
admet-2414	204	19	/	/	PUNCT
admet-2414	204	20	nm	nm	PROPN
admet-2414	204	21	kml	kml	PROPN
admet-2414	204	22	/nm	/nm	PUNCT
admet-2414	204	23	dexamethasone	dexamethasone	NOUN
admet-2414	204	24	5	5	NUM
admet-2414	204	25	155	155	NUM
admet-2414	204	26	5	5	NUM
admet-2414	204	27	0.00079	0.00079	NUM
admet-2414	204	28	cortisol	cortisol	NOUN
admet-2414	204	29	50	50	NUM
admet-2414	204	30	1550	1550	NUM
admet-2414	204	31	75	75	NUM
admet-2414	204	32	0.0118	0.0118	NUM
admet-2414	204	33	prednisolone	prednisolone	PROPN
admet-2414	204	34	15	15	NUM
admet-2414	204	35	465	465	NUM
admet-2414	204	36	15	15	NUM
admet-2414	204	37	0.0044	0.0044	NUM
admet-2414	204	38	methylprednisolone	methylprednisolone	NOUN
admet-2414	204	39	15	15	NUM
admet-2414	204	40	465	465	NUM
admet-2414	204	41	15	15	NUM
admet-2414	204	42	0.00236	0.00236	NUM
admet-2414	204	43	there	there	PRON
admet-2414	204	44	are	be	VERB
admet-2414	204	45	two	two	NUM
admet-2414	204	46	situations	situation	NOUN
admet-2414	204	47	where	where	SCONJ
admet-2414	204	48	the	the	DET
admet-2414	204	49	exact	exact	ADJ
admet-2414	204	50	gr	gr	NOUN
admet-2414	204	51	model	model	NOUN
admet-2414	204	52	may	may	AUX
admet-2414	204	53	become	become	VERB
admet-2414	204	54	important	important	ADJ
admet-2414	204	55	and	and	CCONJ
admet-2414	204	56	the	the	DET
admet-2414	204	57	simple	simple	ADJ
admet-2414	204	58	experimental	experimental	ADJ
admet-2414	204	59	michaelis	michaeli	NOUN
admet-2414	204	60	-	-	PUNCT
admet-2414	204	61	menten	menten	ADJ
admet-2414	204	62	equation	equation	NOUN
admet-2414	204	63	(	(	PUNCT
admet-2414	204	64	1	1	X
admet-2414	204	65	)	)	PUNCT
admet-2414	204	66	is	be	AUX
admet-2414	204	67	not	not	PART
admet-2414	204	68	valid	valid	ADJ
admet-2414	204	69	.	.	PUNCT
admet-2414	205	1	the	the	DET
admet-2414	205	2	first	first	ADJ
admet-2414	205	3	is	be	AUX
admet-2414	205	4	at	at	ADP
admet-2414	205	5	very	very	ADV
admet-2414	205	6	low	low	ADJ
admet-2414	205	7	g	g	NOUN
admet-2414	205	8	concentrations	concentration	NOUN
admet-2414	205	9	where	where	SCONJ
admet-2414	205	10	,	,	PUNCT
admet-2414	205	11	as	as	SCONJ
admet-2414	205	12	discussed	discuss	VERB
admet-2414	205	13	above	above	ADV
admet-2414	205	14	,	,	PUNCT
admet-2414	205	15	the	the	DET
admet-2414	205	16	apparent	apparent	ADJ
admet-2414	205	17	affinity	affinity	NOUN
admet-2414	205	18	may	may	AUX
admet-2414	205	19	be	be	AUX
admet-2414	205	20	increased	increase	VERB
admet-2414	205	21	by	by	ADP
admet-2414	205	22	a	a	DET
admet-2414	205	23	factor	factor	NOUN
admet-2414	205	24	of	of	ADP
admet-2414	205	25	1000	1000	NUM
admet-2414	205	26	or	or	CCONJ
admet-2414	205	27	more	more	ADJ
admet-2414	205	28	.	.	PUNCT
admet-2414	206	1	the	the	DET
admet-2414	206	2	second	second	ADJ
admet-2414	206	3	situation	situation	NOUN
admet-2414	206	4	is	be	AUX
admet-2414	206	5	the	the	DET
admet-2414	206	6	question	question	NOUN
admet-2414	206	7	of	of	ADP
admet-2414	206	8	the	the	DET
admet-2414	206	9	validity	validity	NOUN
admet-2414	206	10	of	of	ADP
admet-2414	206	11	the	the	DET
admet-2414	206	12	steady	steady	ADJ
admet-2414	206	13	state	state	NOUN
admet-2414	206	14	michaelis	michaelis	PROPN
admet-2414	206	15	-	-	PUNCT
admet-2414	206	16	menton	menton	PROPN
admet-2414	206	17	relation	relation	NOUN
admet-2414	206	18	in	in	ADP
admet-2414	206	19	the	the	DET
admet-2414	206	20	presence	presence	NOUN
admet-2414	206	21	of	of	ADP
admet-2414	206	22	time	time	NOUN
admet-2414	206	23	-	-	PUNCT
admet-2414	206	24	varying	vary	VERB
admet-2414	206	25	plasma	plasma	NOUN
admet-2414	206	26	g	g	NOUN
admet-2414	206	27	concentration	concentration	NOUN
admet-2414	206	28	.	.	PUNCT
admet-2414	207	1	the	the	DET
admet-2414	207	2	gr	gr	PROPN
admet-2414	207	3	cycles	cycle	NOUN
admet-2414	207	4	through	through	ADP
admet-2414	207	5	a	a	DET
admet-2414	207	6	series	series	NOUN
admet-2414	207	7	of	of	ADP
admet-2414	207	8	states	state	NOUN
admet-2414	207	9	with	with	ADP
admet-2414	207	10	some	some	DET
admet-2414	207	11	time	time	NOUN
admet-2414	207	12	delays	delay	NOUN
admet-2414	207	13	(	(	PUNCT
admet-2414	207	14	see	see	VERB
admet-2414	207	15	figure	figure	NOUN
admet-2414	207	16	5	5	NUM
admet-2414	207	17	)	)	PUNCT
admet-2414	207	18	,	,	PUNCT
admet-2414	207	19	and	and	CCONJ
admet-2414	207	20	the	the	DET
admet-2414	207	21	steady	steady	ADJ
admet-2414	207	22	state	state	NOUN
admet-2414	207	23	assumption	assumption	NOUN
admet-2414	207	24	may	may	AUX
admet-2414	207	25	not	not	PART
admet-2414	207	26	be	be	AUX
admet-2414	207	27	accurate	accurate	ADJ
admet-2414	207	28	.	.	PUNCT
admet-2414	208	1	both	both	PRON
admet-2414	208	2	of	of	ADP
admet-2414	208	3	these	these	DET
admet-2414	208	4	situations	situation	NOUN
admet-2414	208	5	are	be	AUX
admet-2414	208	6	discussed	discuss	VERB
admet-2414	208	7	below	below	ADV
admet-2414	208	8	.	.	PUNCT
admet-2414	209	1	for	for	ADP
admet-2414	209	2	the	the	DET
admet-2414	209	3	calculations	calculation	NOUN
admet-2414	209	4	that	that	PRON
admet-2414	209	5	use	use	VERB
admet-2414	209	6	the	the	DET
admet-2414	209	7	complete	complete	ADJ
admet-2414	209	8	model	model	NOUN
admet-2414	209	9	,	,	PUNCT
admet-2414	209	10	it	it	PRON
admet-2414	209	11	will	will	AUX
admet-2414	209	12	be	be	AUX
admet-2414	209	13	assumed	assume	VERB
admet-2414	209	14	that	that	SCONJ
admet-2414	209	15	the	the	DET
admet-2414	209	16	rate	rate	NOUN
admet-2414	209	17	constants	constant	NOUN
admet-2414	209	18	k1	k1	NOUN
admet-2414	209	19	–	–	PUNCT
admet-2414	209	20	k6	k6	NOUN
admet-2414	209	21	are	be	AUX
admet-2414	209	22	g	g	NOUN
admet-2414	209	23	independent	independent	ADJ
admet-2414	209	24	(	(	PUNCT
admet-2414	209	25	table	table	NOUN
admet-2414	209	26	1	1	NUM
admet-2414	209	27	)	)	PUNCT
admet-2414	209	28	and	and	CCONJ
admet-2414	209	29	only	only	ADV
admet-2414	209	30	the	the	DET
admet-2414	209	31	equilibrium	equilibrium	NOUN
admet-2414	209	32	constants	constant	NOUN
admet-2414	209	33	kn	kn	PROPN
admet-2414	209	34	and	and	CCONJ
admet-2414	209	35	kc	kc	PROPN
admet-2414	209	36	are	be	AUX
admet-2414	209	37	glucocorticoid	glucocorticoid	ADJ
admet-2414	209	38	dependent	dependent	ADJ
admet-2414	209	39	.	.	PUNCT
admet-2414	210	1	the	the	DET
admet-2414	210	2	value	value	NOUN
admet-2414	210	3	of	of	ADP
admet-2414	210	4	kn	kn	PROPN
admet-2414	210	5	in	in	ADP
admet-2414	210	6	table	table	NOUN
admet-2414	210	7	3	3	NUM
admet-2414	210	8	is	be	AUX
admet-2414	210	9	determined	determine	VERB
admet-2414	210	10	from	from	ADP
admet-2414	210	11	equation	equation	NOUN
admet-2414	210	12	(	(	PUNCT
admet-2414	210	13	3	3	NUM
admet-2414	210	14	)	)	PUNCT
admet-2414	210	15	with	with	ADP
admet-2414	210	16	kmh	kmh	PROPN
admet-2414	210	17	=	=	SYM
admet-2414	210	18	kmt	kmt	PROPN
admet-2414	210	19	.	.	PUNCT
admet-2414	211	1	the	the	DET
admet-2414	211	2	values	value	NOUN
admet-2414	211	3	of	of	ADP
admet-2414	211	4	kc	kc	PROPN
admet-2414	211	5	for	for	ADP
admet-2414	211	6	dex	dex	NOUN
admet-2414	211	7	and	and	CCONJ
admet-2414	211	8	cortisol	cortisol	NOUN
admet-2414	211	9	were	be	AUX
admet-2414	211	10	discussed	discuss	VERB
admet-2414	211	11	above	above	ADP
admet-2414	211	12	(	(	PUNCT
admet-2414	211	13	table	table	NOUN
admet-2414	211	14	1	1	NUM
admet-2414	211	15	)	)	PUNCT
admet-2414	211	16	and	and	CCONJ
admet-2414	211	17	it	it	PRON
admet-2414	211	18	was	be	AUX
admet-2414	211	19	assumed	assume	VERB
admet-2414	211	20	that	that	SCONJ
admet-2414	211	21	kc	kc	PROPN
admet-2414	211	22	=	=	PUNCT
admet-2414	211	23	kmh	kmh	PROPN
admet-2414	211	24	for	for	ADP
admet-2414	211	25	mp	mp	PROPN
admet-2414	211	26	and	and	CCONJ
admet-2414	211	27	prednisone	prednisone	NOUN
admet-2414	211	28	.	.	PUNCT
admet-2414	212	1	in	in	ADP
admet-2414	212	2	all	all	DET
admet-2414	212	3	the	the	DET
admet-2414	212	4	following	following	ADJ
admet-2414	212	5	model	model	NOUN
admet-2414	212	6	plots	plot	NOUN
admet-2414	212	7	,	,	PUNCT
admet-2414	212	8	to	to	PART
admet-2414	212	9	eliminate	eliminate	VERB
admet-2414	212	10	initial	initial	ADJ
admet-2414	212	11	value	value	NOUN
admet-2414	212	12	effects	effect	NOUN
admet-2414	212	13	,	,	PUNCT
admet-2414	212	14	the	the	DET
admet-2414	212	15	calculations	calculation	NOUN
admet-2414	212	16	are	be	AUX
admet-2414	212	17	run	run	VERB
admet-2414	212	18	for	for	ADP
admet-2414	212	19	two	two	NUM
admet-2414	212	20	days	day	NOUN
admet-2414	212	21	and	and	CCONJ
admet-2414	212	22	only	only	ADV
admet-2414	212	23	the	the	DET
admet-2414	212	24	second	second	ADJ
admet-2414	212	25	day	day	NOUN
admet-2414	212	26	is	be	AUX
admet-2414	212	27	plotted	plot	VERB
admet-2414	212	28	.	.	PUNCT
admet-2414	213	1	time	time	NOUN
admet-2414	213	2	of	of	ADP
admet-2414	213	3	day	day	NOUN
admet-2414	213	4	,	,	PUNCT
admet-2414	213	5	h	h	NOUN
admet-2414	213	6	figure	figure	NOUN
admet-2414	213	7	7	7	NUM
admet-2414	213	8	.	.	PUNCT
admet-2414	213	9	daily	daily	ADJ
admet-2414	213	10	endogenous	endogenous	ADJ
admet-2414	213	11	human	human	ADJ
admet-2414	213	12	free	free	ADJ
admet-2414	213	13	plasma	plasma	NOUN
admet-2414	213	14	cortisol	cortisol	NOUN
admet-2414	213	15	the	the	DET
admet-2414	213	16	diurnal	diurnal	ADJ
admet-2414	213	17	endogenous	endogenous	ADJ
admet-2414	213	18	cortisol	cortisol	NOUN
admet-2414	213	19	calculations	calculation	NOUN
admet-2414	213	20	are	be	AUX
admet-2414	213	21	based	base	VERB
admet-2414	213	22	on	on	ADP
admet-2414	213	23	the	the	DET
admet-2414	213	24	measurements	measurement	NOUN
admet-2414	213	25	of	of	ADP
admet-2414	213	26	bhake	bhake	NOUN
admet-2414	213	27	et	et	PROPN
admet-2414	213	28	.	.	PUNCT
admet-2414	214	1	al	al	PROPN
admet-2414	214	2	.	.	PUNCT
admet-2414	215	1	[	[	X
admet-2414	215	2	41	41	NUM
admet-2414	215	3	]	]	PUNCT
admet-2414	215	4	of	of	ADP
admet-2414	215	5	the	the	DET
admet-2414	215	6	human	human	ADJ
admet-2414	215	7	daily	daily	ADJ
admet-2414	215	8	free	free	ADJ
admet-2414	215	9	unbound	unbound	NOUN
admet-2414	215	10	cortisol	cortisol	NOUN
admet-2414	215	11	concentrations	concentration	NOUN
admet-2414	215	12	.	.	PUNCT
admet-2414	216	1	they	they	PRON
admet-2414	216	2	used	use	VERB
admet-2414	216	3	microdialysis	microdialysis	NOUN
admet-2414	216	4	to	to	PART
admet-2414	216	5	obtain	obtain	VERB
admet-2414	216	6	nearly	nearly	ADV
admet-2414	216	7	continuous	continuous	ADJ
admet-2414	216	8	values	value	NOUN
admet-2414	216	9	of	of	ADP
admet-2414	216	10	the	the	DET
admet-2414	216	11	free	free	ADJ
admet-2414	216	12	subcutaneous	subcutaneous	ADJ
admet-2414	216	13	cortisol	cortisol	NOUN
admet-2414	216	14	,	,	PUNCT
admet-2414	216	15	which	which	PRON
admet-2414	216	16	,	,	PUNCT
admet-2414	216	17	it	it	PRON
admet-2414	216	18	will	will	AUX
admet-2414	216	19	be	be	AUX
admet-2414	216	20	assumed	assume	VERB
admet-2414	216	21	,	,	PUNCT
admet-2414	216	22	should	should	AUX
admet-2414	216	23	be	be	AUX
admet-2414	216	24	nearly	nearly	ADV
admet-2414	216	25	equal	equal	ADJ
admet-2414	216	26	to	to	ADP
admet-2414	216	27	the	the	DET
admet-2414	216	28	free	free	ADJ
admet-2414	216	29	plasma	plasma	NOUN
admet-2414	216	30	concentration	concentration	NOUN
admet-2414	216	31	.	.	PUNCT
admet-2414	217	1	there	there	PRON
admet-2414	217	2	is	be	VERB
admet-2414	217	3	considerable	considerable	ADJ
admet-2414	217	4	individual	individual	ADJ
admet-2414	217	5	variation	variation	NOUN
admet-2414	217	6	in	in	ADP
admet-2414	217	7	the	the	DET
admet-2414	217	8	results	result	NOUN
admet-2414	217	9	,	,	PUNCT
admet-2414	217	10	and	and	CCONJ
admet-2414	217	11	figure	figure	VERB
admet-2414	217	12	7	7	NUM
admet-2414	217	13	shows	show	VERB
admet-2414	217	14	a	a	DET
admet-2414	217	15	representative	representative	ADJ
admet-2414	217	16	24	24	NUM
admet-2414	217	17	-	-	PUNCT
admet-2414	217	18	hour	hour	NOUN
admet-2414	217	19	measurement	measurement	NOUN
admet-2414	217	20	.	.	PUNCT
admet-2414	218	1	the	the	DET
admet-2414	218	2	red	red	ADJ
admet-2414	218	3	circles	circle	NOUN
admet-2414	218	4	are	be	AUX
admet-2414	218	5	the	the	DET
admet-2414	218	6	individual	individual	ADJ
admet-2414	218	7	measurements	measurement	NOUN
admet-2414	218	8	,	,	PUNCT
admet-2414	218	9	and	and	CCONJ
admet-2414	218	10	the	the	DET
admet-2414	218	11	solid	solid	ADJ
admet-2414	218	12	line	line	NOUN
admet-2414	218	13	is	be	AUX
admet-2414	218	14	the	the	DET
admet-2414	218	15	piecewise	piecewise	NOUN
admet-2414	218	16	polynomial	polynomial	ADJ
admet-2414	218	17	fit	fit	NOUN
admet-2414	218	18	to	to	ADP
admet-2414	218	19	the	the	DET
admet-2414	218	20	data	datum	NOUN
admet-2414	218	21	that	that	PRON
admet-2414	218	22	is	be	AUX
admet-2414	218	23	used	use	VERB
admet-2414	218	24	in	in	ADP
admet-2414	218	25	the	the	DET
admet-2414	218	26	following	follow	VERB
admet-2414	218	27	calculations	calculation	NOUN
admet-2414	218	28	of	of	ADP
admet-2414	218	29	the	the	DET
admet-2414	218	30	transcriptional	transcriptional	ADJ
admet-2414	218	31	activity	activity	NOUN
admet-2414	218	32	.	.	PUNCT
admet-2414	219	1	figure	figure	NOUN
admet-2414	219	2	8	8	NUM
admet-2414	219	3	shows	show	VERB
admet-2414	219	4	this	this	DET
admet-2414	219	5	daily	daily	ADJ
admet-2414	219	6	variation	variation	NOUN
admet-2414	219	7	in	in	ADP
admet-2414	219	8	free	free	ADJ
admet-2414	219	9	plasma	plasma	NOUN
admet-2414	219	10	cortisol	cortisol	NOUN
admet-2414	219	11	(	(	PUNCT
admet-2414	219	12	green	green	ADJ
admet-2414	219	13	line	line	NOUN
admet-2414	219	14	)	)	PUNCT
admet-2414	219	15	and	and	CCONJ
admet-2414	219	16	the	the	DET
admet-2414	219	17	corresponding	corresponding	ADJ
admet-2414	219	18	transcriptional	transcriptional	ADJ
admet-2414	219	19	activity	activity	NOUN
admet-2414	219	20	for	for	ADP
admet-2414	219	21	three	three	NUM
admet-2414	219	22	different	different	ADJ
admet-2414	219	23	model	model	NOUN
admet-2414	219	24	assumptions	assumption	NOUN
admet-2414	219	25	.	.	PUNCT
admet-2414	220	1	because	because	SCONJ
admet-2414	220	2	the	the	DET
admet-2414	220	3	nuclear	nuclear	ADJ
admet-2414	220	4	gr	gr	NOUN
admet-2414	220	5	continually	continually	ADV
admet-2414	220	6	cycles	cycle	VERB
admet-2414	220	7	through	through	ADP
admet-2414	220	8	a	a	DET
admet-2414	220	9	series	series	NOUN
admet-2414	220	10	of	of	ADP
admet-2414	220	11	states	state	NOUN
admet-2414	220	12	(	(	PUNCT
admet-2414	220	13	figure	figure	NOUN
admet-2414	220	14	1	1	NUM
admet-2414	220	15	)	)	PUNCT
admet-2414	220	16	,	,	PUNCT
admet-2414	220	17	not	not	PART
admet-2414	220	18	all	all	DET
admet-2414	220	19	the	the	DET
admet-2414	220	20	receptors	receptor	NOUN
admet-2414	220	21	can	can	AUX
admet-2414	220	22	be	be	AUX
admet-2414	220	23	in	in	ADP
admet-2414	220	24	the	the	DET
admet-2414	220	25	rngn	rngn	NOUN
admet-2414	220	26	state	state	NOUN
admet-2414	220	27	,	,	PUNCT
admet-2414	220	28	even	even	ADV
admet-2414	220	29	at	at	ADP
admet-2414	220	30	infinite	infinite	ADJ
admet-2414	220	31	fr	fr	NOUN
admet-2414	220	32	e	e	PROPN
admet-2414	220	33	e	e	NOUN
admet-2414	220	34	p	p	PROPN
admet-2414	220	35	la	la	PROPN
admet-2414	220	36	sm	sm	PROPN
admet-2414	220	37	a	a	DET
admet-2414	220	38	co	co	X
admet-2414	220	39	rt	rt	PROPN
admet-2414	220	40	is	be	AUX
admet-2414	220	41	o	o	NOUN
admet-2414	220	42	l	l	NOUN
admet-2414	220	43	c	c	NOUN
admet-2414	221	1	o	o	X
admet-2414	221	2	n	n	X
admet-2414	221	3	ce	ce	PROPN
admet-2414	221	4	n	n	CCONJ
admet-2414	221	5	tr	tr	VERB
admet-2414	221	6	at	at	ADP
admet-2414	221	7	io	io	X
admet-2414	221	8	n	n	PROPN
admet-2414	221	9	,	,	PUNCT
admet-2414	221	10	n	n	CCONJ
admet-2414	221	11	m	m	PROPN
admet-2414	221	12	admet	admet	PROPN
admet-2414	221	13	&	&	CCONJ
admet-2414	221	14	dmpk	dmpk	PROPN
admet-2414	221	15	12(6	12(6	NUM
admet-2414	221	16	)	)	PUNCT
admet-2414	221	17	(	(	PUNCT
admet-2414	221	18	2024	2024	NUM
admet-2414	221	19	)	)	PUNCT
admet-2414	221	20	971	971	NUM
admet-2414	221	21	-	-	SYM
admet-2414	221	22	989	989	NUM
admet-2414	221	23	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	221	24	/	/	SYM
admet-2414	221	25	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	221	26	of	of	ADP
admet-2414	221	27	glucocorticoids	glucocorticoid	NOUN
admet-2414	221	28	doi	doi	NOUN
admet-2414	221	29	:	:	PUNCT
admet-2414	221	30	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	221	31	981	981	NUM
admet-2414	221	32	glucocorticoid	glucocorticoid	ADJ
admet-2414	221	33	concentration	concentration	NOUN
admet-2414	221	34	(	(	PUNCT
admet-2414	221	35	see	see	VERB
admet-2414	221	36	figure	figure	NOUN
admet-2414	221	37	5	5	NUM
admet-2414	221	38	)	)	PUNCT
admet-2414	221	39	.	.	PUNCT
admet-2414	222	1	in	in	ADP
admet-2414	222	2	figure	figure	NOUN
admet-2414	222	3	8	8	NUM
admet-2414	222	4	,	,	PUNCT
admet-2414	222	5	the	the	DET
admet-2414	222	6	left	left	ADJ
admet-2414	222	7	y	y	PROPN
admet-2414	222	8	coordinate	coordinate	NOUN
admet-2414	222	9	is	be	AUX
admet-2414	222	10	the	the	DET
admet-2414	222	11	value	value	NOUN
admet-2414	222	12	fraction	fraction	NOUN
admet-2414	222	13	of	of	ADP
admet-2414	222	14	the	the	DET
admet-2414	222	15	gr	gr	NOUN
admet-2414	222	16	that	that	PRON
admet-2414	222	17	is	be	AUX
admet-2414	222	18	in	in	ADP
admet-2414	222	19	the	the	DET
admet-2414	222	20	state	state	NOUN
admet-2414	222	21	rngn	rngn	NOUN
admet-2414	222	22	relative	relative	ADJ
admet-2414	222	23	to	to	ADP
admet-2414	222	24	the	the	DET
admet-2414	222	25	maximum	maximum	ADJ
admet-2414	222	26	fraction	fraction	NOUN
admet-2414	222	27	of	of	ADP
admet-2414	222	28	gr	gr	PROPN
admet-2414	222	29	in	in	ADP
admet-2414	222	30	rngn	rngn	NOUN
admet-2414	222	31	(=	(=	X
admet-2414	222	32	rngnmax	rngnmax	ADV
admet-2414	222	33	=	=	SYM
admet-2414	222	34	0.806	0.806	NUM
admet-2414	222	35	)	)	PUNCT
admet-2414	222	36	for	for	ADP
admet-2414	222	37	an	an	DET
admet-2414	222	38	infinite	infinite	ADJ
admet-2414	222	39	cortisol	cortisol	ADJ
admet-2414	222	40	concentration	concentration	NOUN
admet-2414	222	41	.	.	PUNCT
admet-2414	223	1	the	the	DET
admet-2414	223	2	blue	blue	ADJ
admet-2414	223	3	line	line	NOUN
admet-2414	223	4	is	be	AUX
admet-2414	223	5	the	the	DET
admet-2414	223	6	simple	simple	ADJ
admet-2414	223	7	high	high	ADJ
admet-2414	223	8	concentration	concentration	NOUN
admet-2414	223	9	michaelis	michaelis	PROPN
admet-2414	223	10	-	-	PUNCT
admet-2414	223	11	menton	menton	PROPN
admet-2414	223	12	relation	relation	PROPN
admet-2414	223	13	(	(	PUNCT
admet-2414	223	14	equation	equation	NOUN
admet-2414	223	15	(	(	PUNCT
admet-2414	223	16	1	1	X
admet-2414	223	17	)	)	PUNCT
admet-2414	223	18	using	use	VERB
admet-2414	223	19	the	the	DET
admet-2414	223	20	experimental	experimental	ADJ
admet-2414	223	21	kmt	kmt	PROPN
admet-2414	223	22	=	=	PUNCT
admet-2414	223	23	kmh	kmh	PROPN
admet-2414	223	24	.	.	PUNCT
admet-2414	224	1	the	the	DET
admet-2414	224	2	red	red	ADJ
admet-2414	224	3	line	line	NOUN
admet-2414	224	4	is	be	AUX
admet-2414	224	5	the	the	DET
admet-2414	224	6	exact	exact	ADJ
admet-2414	224	7	model	model	NOUN
admet-2414	224	8	steady	steady	ADJ
admet-2414	224	9	state	state	NOUN
admet-2414	224	10	expression	expression	NOUN
admet-2414	224	11	(	(	PUNCT
admet-2414	224	12	equation	equation	NOUN
admet-2414	224	13	(	(	PUNCT
admet-2414	224	14	2	2	NUM
admet-2414	224	15	)	)	PUNCT
admet-2414	224	16	)	)	PUNCT
admet-2414	224	17	assuming	assume	VERB
admet-2414	224	18	that	that	SCONJ
admet-2414	224	19	the	the	DET
admet-2414	224	20	nuclear	nuclear	ADJ
admet-2414	224	21	activity	activity	NOUN
admet-2414	224	22	is	be	AUX
admet-2414	224	23	proportional	proportional	ADJ
admet-2414	224	24	to	to	ADP
admet-2414	224	25	the	the	DET
admet-2414	224	26	fraction	fraction	NOUN
admet-2414	224	27	of	of	ADP
admet-2414	224	28	gr	gr	PRON
admet-2414	224	29	in	in	ADP
admet-2414	224	30	the	the	DET
admet-2414	224	31	rngn	rngn	PROPN
admet-2414	224	32	state	state	NOUN
admet-2414	224	33	.	.	PUNCT
admet-2414	225	1	the	the	DET
admet-2414	225	2	black	black	ADJ
admet-2414	225	3	line	line	NOUN
admet-2414	225	4	is	be	AUX
admet-2414	225	5	the	the	DET
admet-2414	225	6	exact	exact	ADJ
admet-2414	225	7	rngn	rngn	NOUN
admet-2414	225	8	fraction	fraction	NOUN
admet-2414	225	9	determined	determine	VERB
admet-2414	225	10	from	from	ADP
admet-2414	225	11	solving	solve	VERB
admet-2414	225	12	the	the	DET
admet-2414	225	13	set	set	NOUN
admet-2414	225	14	of	of	ADP
admet-2414	225	15	time	time	NOUN
admet-2414	225	16	dependent	dependent	ADJ
admet-2414	225	17	differential	differential	ADJ
admet-2414	225	18	equations	equation	NOUN
admet-2414	225	19	that	that	PRON
admet-2414	225	20	describe	describe	VERB
admet-2414	225	21	the	the	DET
admet-2414	225	22	model	model	NOUN
admet-2414	225	23	(	(	PUNCT
admet-2414	225	24	see	see	VERB
admet-2414	225	25	supplement	supplement	NOUN
admet-2414	225	26	i	i	PRON
admet-2414	225	27	for	for	ADP
admet-2414	225	28	details	detail	NOUN
admet-2414	225	29	)	)	PUNCT
admet-2414	225	30	.	.	PUNCT
admet-2414	226	1	to	to	PART
admet-2414	226	2	eliminate	eliminate	VERB
admet-2414	226	3	initial	initial	ADJ
admet-2414	226	4	value	value	NOUN
admet-2414	226	5	effects	effect	NOUN
admet-2414	226	6	,	,	PUNCT
admet-2414	226	7	the	the	DET
admet-2414	226	8	model	model	NOUN
admet-2414	226	9	results	result	NOUN
admet-2414	226	10	were	be	AUX
admet-2414	226	11	determined	determine	VERB
admet-2414	226	12	for	for	ADP
admet-2414	226	13	2	2	NUM
admet-2414	226	14	days	day	NOUN
admet-2414	226	15	,	,	PUNCT
admet-2414	226	16	and	and	CCONJ
admet-2414	226	17	the	the	DET
admet-2414	226	18	plotted	plot	VERB
admet-2414	226	19	data	data	NOUN
admet-2414	226	20	is	be	AUX
admet-2414	226	21	for	for	ADP
admet-2414	226	22	the	the	DET
admet-2414	226	23	second	second	ADJ
admet-2414	226	24	day	day	NOUN
admet-2414	226	25	.	.	PUNCT
admet-2414	227	1	time	time	NOUN
admet-2414	227	2	of	of	ADP
admet-2414	227	3	day	day	NOUN
admet-2414	227	4	,	,	PUNCT
admet-2414	227	5	h	h	NOUN
admet-2414	227	6	figure	figure	NOUN
admet-2414	227	7	8	8	NUM
admet-2414	227	8	.	.	PUNCT
admet-2414	227	9	endogenous	endogenous	ADJ
admet-2414	227	10	human	human	ADJ
admet-2414	227	11	cortisol	cortisol	ADJ
admet-2414	227	12	nuclear	nuclear	ADJ
admet-2414	227	13	transcription	transcription	NOUN
admet-2414	227	14	activity	activity	NOUN
admet-2414	227	15	as	as	ADP
admet-2414	227	16	fraction	fraction	NOUN
admet-2414	227	17	of	of	ADP
admet-2414	227	18	maximum	maximum	ADJ
admet-2414	227	19	possible	possible	ADJ
admet-2414	227	20	.	.	PUNCT
admet-2414	228	1	the	the	DET
admet-2414	228	2	free	free	ADJ
admet-2414	228	3	plasma	plasma	NOUN
admet-2414	228	4	cortisol	cortisol	NOUN
admet-2414	228	5	concentration	concentration	NOUN
admet-2414	228	6	(	(	PUNCT
admet-2414	228	7	green	green	ADJ
admet-2414	228	8	line	line	NOUN
admet-2414	228	9	)	)	PUNCT
admet-2414	228	10	is	be	AUX
admet-2414	228	11	indicated	indicate	VERB
admet-2414	228	12	on	on	ADP
admet-2414	228	13	right	right	ADJ
admet-2414	228	14	y	y	PROPN
admet-2414	228	15	axis	axis	NOUN
admet-2414	228	16	,	,	PUNCT
admet-2414	228	17	and	and	CCONJ
admet-2414	228	18	the	the	DET
admet-2414	228	19	gr	gr	NOUN
admet-2414	228	20	transcriptional	transcriptional	ADJ
admet-2414	228	21	activity	activity	NOUN
admet-2414	228	22	for	for	ADP
admet-2414	228	23	three	three	NUM
admet-2414	228	24	different	different	ADJ
admet-2414	228	25	approximations	approximation	NOUN
admet-2414	228	26	(	(	PUNCT
admet-2414	228	27	red	red	ADJ
admet-2414	228	28	,	,	PUNCT
admet-2414	228	29	black	black	ADJ
admet-2414	228	30	and	and	CCONJ
admet-2414	228	31	blue	blue	ADJ
admet-2414	228	32	lines	line	NOUN
admet-2414	228	33	)	)	PUNCT
admet-2414	228	34	is	be	AUX
admet-2414	228	35	indicated	indicate	VERB
admet-2414	228	36	on	on	ADP
admet-2414	228	37	left	leave	VERB
admet-2414	228	38	y	y	PROPN
admet-2414	228	39	axis	axis	NOUN
admet-2414	228	40	as	as	SCONJ
admet-2414	228	41	expected	expect	VERB
admet-2414	228	42	,	,	PUNCT
admet-2414	228	43	although	although	SCONJ
admet-2414	228	44	the	the	DET
admet-2414	228	45	experimental	experimental	ADJ
admet-2414	228	46	michaelis	michaelis	PROPN
admet-2414	228	47	-	-	PUNCT
admet-2414	228	48	menton	menton	PROPN
admet-2414	228	49	relation	relation	PROPN
admet-2414	228	50	(	(	PUNCT
admet-2414	228	51	blue	blue	ADJ
admet-2414	228	52	line	line	NOUN
admet-2414	228	53	)	)	PUNCT
admet-2414	228	54	is	be	AUX
admet-2414	228	55	a	a	DET
admet-2414	228	56	good	good	ADJ
admet-2414	228	57	approximation	approximation	NOUN
admet-2414	228	58	at	at	ADP
admet-2414	228	59	high	high	ADJ
admet-2414	228	60	concentrations	concentration	NOUN
admet-2414	228	61	,	,	PUNCT
admet-2414	228	62	it	it	PRON
admet-2414	228	63	significantly	significantly	ADV
admet-2414	228	64	underestimates	underestimate	VERB
admet-2414	228	65	the	the	DET
admet-2414	228	66	activity	activity	NOUN
admet-2414	228	67	at	at	ADP
admet-2414	228	68	low	low	ADJ
admet-2414	228	69	concentrations	concentration	NOUN
admet-2414	228	70	.	.	PUNCT
admet-2414	229	1	for	for	ADP
admet-2414	229	2	example	example	NOUN
admet-2414	229	3	,	,	PUNCT
admet-2414	229	4	at	at	ADP
admet-2414	229	5	the	the	DET
admet-2414	229	6	nadir	nadir	NOUN
admet-2414	229	7	cortisol	cortisol	ADJ
admet-2414	229	8	concentration	concentration	NOUN
admet-2414	229	9	of	of	ADP
admet-2414	229	10	1.45	1.45	NUM
admet-2414	229	11	nm	nm	NOUN
admet-2414	229	12	at	at	ADP
admet-2414	229	13	about	about	ADV
admet-2414	229	14	3	3	NUM
admet-2414	229	15	am	am	NOUN
admet-2414	229	16	,	,	PUNCT
admet-2414	229	17	the	the	DET
admet-2414	229	18	exact	exact	ADJ
admet-2414	229	19	time	time	NOUN
admet-2414	229	20	dependent	dependent	ADJ
admet-2414	229	21	activity	activity	NOUN
admet-2414	229	22	(	(	PUNCT
admet-2414	229	23	black	black	ADJ
admet-2414	229	24	line	line	NOUN
admet-2414	229	25	)	)	PUNCT
admet-2414	229	26	is	be	AUX
admet-2414	229	27	0.074	0.074	NUM
admet-2414	229	28	,	,	PUNCT
admet-2414	229	29	2.6	2.6	NUM
admet-2414	229	30	times	time	NOUN
admet-2414	229	31	greater	great	ADJ
admet-2414	229	32	than	than	ADP
admet-2414	229	33	the	the	DET
admet-2414	229	34	michaelis	michaelis	PROPN
admet-2414	229	35	-	-	PUNCT
admet-2414	229	36	menton	menton	PROPN
admet-2414	229	37	activity	activity	NOUN
admet-2414	229	38	(	(	PUNCT
admet-2414	229	39	blue	blue	ADJ
admet-2414	229	40	line	line	NOUN
admet-2414	229	41	)	)	PUNCT
admet-2414	229	42	of	of	ADP
admet-2414	229	43	0.028	0.028	NUM
admet-2414	229	44	.	.	PUNCT
admet-2414	230	1	the	the	DET
admet-2414	230	2	steady	steady	ADJ
admet-2414	230	3	state	state	NOUN
admet-2414	230	4	model	model	NOUN
admet-2414	230	5	result	result	NOUN
admet-2414	230	6	(	(	PUNCT
admet-2414	230	7	red	red	ADJ
admet-2414	230	8	line	line	NOUN
admet-2414	230	9	)	)	PUNCT
admet-2414	230	10	is	be	AUX
admet-2414	230	11	nearly	nearly	ADV
admet-2414	230	12	identical	identical	ADJ
admet-2414	230	13	to	to	ADP
admet-2414	230	14	the	the	DET
admet-2414	230	15	exact	exact	ADJ
admet-2414	230	16	time	time	NOUN
admet-2414	230	17	dependent	dependent	ADJ
admet-2414	230	18	result	result	NOUN
admet-2414	230	19	(	(	PUNCT
admet-2414	230	20	black	black	ADJ
admet-2414	230	21	line	line	NOUN
admet-2414	230	22	)	)	PUNCT
admet-2414	230	23	,	,	PUNCT
admet-2414	230	24	with	with	ADP
admet-2414	230	25	only	only	ADV
admet-2414	230	26	a	a	DET
admet-2414	230	27	small	small	ADJ
admet-2414	230	28	-	-	PUNCT
admet-2414	230	29	time	time	NOUN
admet-2414	230	30	delay	delay	NOUN
admet-2414	230	31	in	in	ADP
admet-2414	230	32	the	the	DET
admet-2414	230	33	activity	activity	NOUN
admet-2414	230	34	.	.	PUNCT
admet-2414	231	1	in	in	ADP
admet-2414	231	2	the	the	DET
admet-2414	231	3	following	follow	VERB
admet-2414	231	4	calculations	calculation	NOUN
admet-2414	231	5	for	for	ADP
admet-2414	231	6	dex	dex	NOUN
admet-2414	231	7	,	,	PUNCT
admet-2414	231	8	mp	mp	PROPN
admet-2414	231	9	and	and	CCONJ
admet-2414	231	10	prednisone	prednisone	NOUN
admet-2414	231	11	,	,	PUNCT
admet-2414	231	12	only	only	ADV
admet-2414	231	13	the	the	DET
admet-2414	231	14	exact	exact	ADJ
admet-2414	231	15	steady	steady	ADJ
admet-2414	231	16	state	state	NOUN
admet-2414	231	17	model	model	NOUN
admet-2414	231	18	result	result	NOUN
admet-2414	231	19	(	(	PUNCT
admet-2414	231	20	equation	equation	NOUN
admet-2414	231	21	(	(	PUNCT
admet-2414	231	22	2	2	NUM
admet-2414	231	23	)	)	PUNCT
admet-2414	231	24	)	)	PUNCT
admet-2414	231	25	will	will	AUX
admet-2414	231	26	be	be	AUX
admet-2414	231	27	used	use	VERB
admet-2414	231	28	for	for	ADP
admet-2414	231	29	the	the	DET
admet-2414	231	30	estimation	estimation	NOUN
admet-2414	231	31	of	of	ADP
admet-2414	231	32	gr	gr	DET
admet-2414	231	33	transcriptional	transcriptional	ADJ
admet-2414	231	34	activity	activity	NOUN
admet-2414	231	35	.	.	PUNCT
admet-2414	232	1	a	a	DET
admet-2414	232	2	new	new	ADJ
admet-2414	232	3	quantitative	quantitative	ADJ
admet-2414	232	4	measure	measure	NOUN
admet-2414	232	5	of	of	ADP
admet-2414	232	6	the	the	DET
admet-2414	232	7	glucocorticoid	glucocorticoid	ADJ
admet-2414	232	8	potency	potency	NOUN
admet-2414	232	9	is	be	AUX
admet-2414	232	10	introduced	introduce	VERB
admet-2414	232	11	:	:	PUNCT
admet-2414	232	12	the	the	DET
admet-2414	232	13	“	"	PUNCT
admet-2414	232	14	glucocorticoid	glucocorticoid	ADJ
admet-2414	232	15	transcription	transcription	NOUN
admet-2414	232	16	quotient	quotient	NOUN
admet-2414	232	17	”	"	PUNCT
admet-2414	232	18	(	(	PUNCT
admet-2414	232	19	gtq	gtq	PROPN
admet-2414	232	20	)	)	PUNCT
admet-2414	232	21	which	which	PRON
admet-2414	232	22	is	be	AUX
admet-2414	232	23	defined	define	VERB
admet-2414	232	24	as	as	ADP
admet-2414	232	25	the	the	DET
admet-2414	232	26	integral	integral	NOUN
admet-2414	232	27	of	of	ADP
admet-2414	232	28	the	the	DET
admet-2414	232	29	gr	gr	NOUN
admet-2414	232	30	activity	activity	NOUN
admet-2414	232	31	(	(	PUNCT
admet-2414	232	32	as	as	ADP
admet-2414	232	33	a	a	DET
admet-2414	232	34	fraction	fraction	NOUN
admet-2414	232	35	of	of	ADP
admet-2414	232	36	the	the	DET
admet-2414	232	37	maximum	maximum	ADJ
admet-2414	232	38	possible	possible	ADJ
admet-2414	232	39	for	for	ADP
admet-2414	232	40	infinite	infinite	ADJ
admet-2414	232	41	g	g	PROPN
admet-2414	232	42	dose	dose	NOUN
admet-2414	232	43	)	)	PUNCT
admet-2414	232	44	averaged	average	VERB
admet-2414	232	45	over	over	ADP
admet-2414	232	46	24	24	NUM
admet-2414	232	47	hours	hour	NOUN
admet-2414	232	48	:	:	PUNCT
admet-2414	232	49	24	24	NUM
admet-2414	232	50	0	0	NUM
admet-2414	232	51	1	1	NUM
admet-2414	232	52	rngn	rngn	NOUN
admet-2414	232	53	(	(	PUNCT
admet-2414	232	54	)	)	PUNCT
admet-2414	232	55	d	d	SYM
admet-2414	232	56	24	24	NUM
admet-2414	232	57	gtq	gtq	PROPN
admet-2414	232	58	f	f	PROPN
admet-2414	232	59	t	t	PROPN
admet-2414	232	60	t	t	PROPN
admet-2414	232	61	rngnmax	rngnmax	ADJ
admet-2414	233	1	=	=	PUNCT
admet-2414	234	1			PUNCT
admet-2414	235	1	(	(	PUNCT
admet-2414	235	2	6	6	NUM
admet-2414	235	3	)	)	PUNCT
admet-2414	235	4	where	where	SCONJ
admet-2414	235	5	frngn(t	frngn(t	NOUN
admet-2414	235	6	)	)	PUNCT
admet-2414	235	7	is	be	AUX
admet-2414	235	8	the	the	DET
admet-2414	235	9	fraction	fraction	NOUN
admet-2414	235	10	of	of	ADP
admet-2414	235	11	gr	gr	PRON
admet-2414	235	12	in	in	ADP
admet-2414	235	13	the	the	DET
admet-2414	235	14	rngn	rngn	NOUN
admet-2414	235	15	state	state	NOUN
admet-2414	235	16	as	as	ADP
admet-2414	235	17	a	a	DET
admet-2414	235	18	function	function	NOUN
admet-2414	235	19	of	of	ADP
admet-2414	235	20	time	time	NOUN
admet-2414	235	21	and	and	CCONJ
admet-2414	235	22	rngnmax	rngnmax	ADJ
admet-2414	235	23	is	be	AUX
admet-2414	235	24	the	the	DET
admet-2414	235	25	maximum	maximum	ADJ
admet-2414	235	26	fraction	fraction	NOUN
admet-2414	235	27	for	for	ADP
admet-2414	235	28	an	an	DET
admet-2414	235	29	infinite	infinite	ADJ
admet-2414	235	30	glucocorticoid	glucocorticoid	NOUN
admet-2414	235	31	dose	dose	NOUN
admet-2414	235	32	.	.	PUNCT
admet-2414	236	1	gtq	gtq	PROPN
admet-2414	236	2	=	=	SYM
admet-2414	236	3	1	1	NUM
admet-2414	236	4	for	for	ADP
admet-2414	236	5	an	an	DET
admet-2414	236	6	infinite	infinite	ADJ
admet-2414	236	7	dose	dose	NOUN
admet-2414	236	8	.	.	PUNCT
admet-2414	237	1	for	for	ADP
admet-2414	237	2	endogenous	endogenous	ADJ
admet-2414	237	3	cortisol	cortisol	NOUN
admet-2414	237	4	(	(	PUNCT
admet-2414	237	5	figure	figure	NOUN
admet-2414	237	6	8)	8)	NUM
admet-2414	237	7	,	,	PUNCT
admet-2414	237	8	the	the	DET
admet-2414	237	9	gtq	gtq	NOUN
admet-2414	237	10	is	be	AUX
admet-2414	237	11	0.17	0.17	NUM
admet-2414	237	12	.	.	PUNCT
admet-2414	238	1	table	table	NOUN
admet-2414	238	2	4	4	NUM
admet-2414	238	3	summarizes	summarize	NOUN
admet-2414	238	4	the	the	DET
admet-2414	238	5	gtq	gtq	NOUN
admet-2414	238	6	for	for	ADP
admet-2414	238	7	cortisol	cortisol	NOUN
admet-2414	238	8	and	and	CCONJ
admet-2414	238	9	for	for	ADP
admet-2414	238	10	varying	vary	VERB
admet-2414	238	11	doses	dose	NOUN
admet-2414	238	12	of	of	ADP
admet-2414	238	13	dex	dex	NOUN
admet-2414	238	14	,	,	PUNCT
admet-2414	238	15	mp	mp	PROPN
admet-2414	238	16	and	and	CCONJ
admet-2414	238	17	prednisone	prednisone	NOUN
admet-2414	238	18	.	.	PUNCT
admet-2414	239	1	the	the	DET
admet-2414	239	2	determination	determination	NOUN
admet-2414	239	3	of	of	ADP
admet-2414	239	4	the	the	DET
admet-2414	239	5	transcriptional	transcriptional	ADJ
admet-2414	239	6	activity	activity	NOUN
admet-2414	239	7	of	of	ADP
admet-2414	239	8	dex	dex	NOUN
admet-2414	239	9	,	,	PUNCT
admet-2414	239	10	mp	mp	PROPN
admet-2414	239	11	and	and	CCONJ
admet-2414	239	12	prednisone	prednisone	NOUN
admet-2414	239	13	is	be	AUX
admet-2414	239	14	obtained	obtain	VERB
admet-2414	239	15	by	by	ADP
admet-2414	239	16	substituting	substitute	VERB
admet-2414	239	17	the	the	DET
admet-2414	239	18	free	free	ADJ
admet-2414	239	19	plasma	plasma	NOUN
admet-2414	239	20	concentration	concentration	NOUN
admet-2414	239	21	as	as	ADP
admet-2414	239	22	a	a	DET
admet-2414	239	23	function	function	NOUN
admet-2414	239	24	of	of	ADP
admet-2414	239	25	time	time	NOUN
admet-2414	240	1	[	[	X
admet-2414	240	2	g	g	X
admet-2414	240	3	]	]	PUNCT
admet-2414	240	4	into	into	ADP
admet-2414	240	5	the	the	DET
admet-2414	240	6	steady	steady	ADJ
admet-2414	240	7	state	state	NOUN
admet-2414	240	8	model	model	NOUN
admet-2414	240	9	relation	relation	NOUN
admet-2414	240	10	equation	equation	NOUN
admet-2414	240	11	(	(	PUNCT
admet-2414	240	12	2	2	NUM
admet-2414	240	13	)	)	PUNCT
admet-2414	240	14	.	.	PUNCT
admet-2414	241	1	the	the	DET
admet-2414	241	2	fr	fr	NOUN
admet-2414	241	3	e	e	PROPN
admet-2414	241	4	e	e	NOUN
admet-2414	241	5	p	p	PROPN
admet-2414	241	6	la	la	PROPN
admet-2414	241	7	sm	sm	PROPN
admet-2414	241	8	a	a	DET
admet-2414	241	9	co	co	X
admet-2414	241	10	rt	rt	PROPN
admet-2414	241	11	is	be	AUX
admet-2414	241	12	o	o	NOUN
admet-2414	241	13	l	l	NOUN
admet-2414	241	14	c	c	NOUN
admet-2414	241	15	o	o	X
admet-2414	241	16	n	n	X
admet-2414	241	17	ce	ce	PROPN
admet-2414	241	18	n	n	CCONJ
admet-2414	241	19	tr	tr	VERB
admet-2414	241	20	at	at	ADP
admet-2414	241	21	io	io	X
admet-2414	241	22	n	n	PROPN
admet-2414	241	23	,	,	PUNCT
admet-2414	241	24	n	n	CCONJ
admet-2414	241	25	m	m	VERB
admet-2414	241	26	c	c	NOUN
admet-2414	241	27	o	o	INTJ
admet-2414	241	28	rt	rt	PROPN
admet-2414	241	29	is	be	AUX
admet-2414	241	30	o	o	NOUN
admet-2414	241	31	l	l	NOUN
admet-2414	242	1	n	n	CCONJ
admet-2414	242	2	u	u	PROPN
admet-2414	242	3	cl	cl	X
admet-2414	242	4	e	e	PROPN
admet-2414	242	5	ar	ar	PROPN
admet-2414	242	6	t	t	PROPN
admet-2414	242	7	ra	ra	PROPN
admet-2414	242	8	n	n	PROPN
admet-2414	242	9	sc	sc	PROPN
admet-2414	242	10	ri	ri	PROPN
admet-2414	242	11	p	p	X
admet-2414	242	12	ti	ti	PROPN
admet-2414	242	13	o	o	NOUN
admet-2414	242	14	n	n	INTJ
admet-2414	242	15	a	a	DET
admet-2414	242	16	ct	ct	NOUN
admet-2414	242	17	iv	iv	NUM
admet-2414	242	18	it	it	PRON
admet-2414	242	19	y	y	PROPN
admet-2414	242	20	free	free	ADJ
admet-2414	242	21	plasma	plasma	NOUN
admet-2414	242	22	cortisol	cortisol	NOUN
admet-2414	242	23	concentration	concentration	NOUN
admet-2414	242	24	gr	gr	NOUN
admet-2414	242	25	transcription	transcription	NOUN
admet-2414	242	26	activity	activity	NOUN
admet-2414	242	27	(	(	PUNCT
admet-2414	242	28	steady	steady	ADJ
admet-2414	242	29	state	state	NOUN
admet-2414	242	30	approximation	approximation	NOUN
admet-2414	242	31	)	)	PUNCT
admet-2414	242	32	gr	gr	NOUN
admet-2414	242	33	transcription	transcription	NOUN
admet-2414	242	34	activity	activity	NOUN
admet-2414	242	35	(	(	PUNCT
admet-2414	242	36	exact	exact	ADJ
admet-2414	242	37	time	time	NOUN
admet-2414	242	38	dependent	dependent	ADJ
admet-2414	242	39	)	)	PUNCT
admet-2414	242	40	gr	gr	NOUN
admet-2414	242	41	transcription	transcription	NOUN
admet-2414	242	42	activity	activity	NOUN
admet-2414	242	43	(	(	PUNCT
admet-2414	242	44	michaelis	michaelis	PROPN
admet-2414	242	45	-	-	PUNCT
admet-2414	242	46	menton	menton	PROPN
admet-2414	242	47	)	)	PUNCT
admet-2414	242	48	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	242	49	d.	d.	PROPN
admet-2414	242	50	g.	g.	PROPN
admet-2414	242	51	levitt	levitt	PROPN
admet-2414	242	52	admet	admet	PROPN
admet-2414	242	53	&	&	CCONJ
admet-2414	242	54	dmpk	dmpk	PROPN
admet-2414	242	55	12(6	12(6	NUM
admet-2414	242	56	)	)	PUNCT
admet-2414	242	57	(	(	PUNCT
admet-2414	242	58	2024	2024	NUM
admet-2414	242	59	)	)	PUNCT
admet-2414	242	60	971	971	NUM
admet-2414	242	61	-	-	SYM
admet-2414	242	62	989	989	NUM
admet-2414	242	63	982	982	NUM
admet-2414	242	64	pk	pk	NOUN
admet-2414	242	65	that	that	PRON
admet-2414	242	66	is	be	AUX
admet-2414	242	67	used	use	VERB
admet-2414	242	68	to	to	PART
admet-2414	242	69	predict	predict	VERB
admet-2414	242	70	the	the	DET
admet-2414	242	71	free	free	ADJ
admet-2414	242	72	plasma	plasma	NOUN
admet-2414	242	73	concentration	concentration	NOUN
admet-2414	242	74	following	follow	VERB
admet-2414	242	75	different	different	ADJ
admet-2414	242	76	oral	oral	NOUN
admet-2414	242	77	and	and	CCONJ
admet-2414	242	78	iv	iv	NUM
admet-2414	242	79	dosages	dosage	NOUN
admet-2414	242	80	is	be	AUX
admet-2414	242	81	described	describe	VERB
admet-2414	242	82	in	in	ADP
admet-2414	242	83	detail	detail	NOUN
admet-2414	242	84	in	in	ADP
admet-2414	242	85	the	the	DET
admet-2414	242	86	attached	attached	ADJ
admet-2414	242	87	file	file	NOUN
admet-2414	242	88	supplement	supplement	PROPN
admet-2414	242	89	ii	ii	PROPN
admet-2414	242	90	.	.	PUNCT
admet-2414	243	1	the	the	DET
admet-2414	243	2	activity	activity	NOUN
admet-2414	243	3	is	be	AUX
admet-2414	243	4	expressed	express	VERB
admet-2414	243	5	as	as	ADP
admet-2414	243	6	the	the	DET
admet-2414	243	7	fractional	fractional	ADJ
admet-2414	243	8	activity	activity	NOUN
admet-2414	243	9	relative	relative	ADJ
admet-2414	243	10	to	to	ADP
admet-2414	243	11	the	the	DET
admet-2414	243	12	maximum	maximum	ADJ
admet-2414	243	13	possible	possible	ADJ
admet-2414	243	14	.	.	PUNCT
admet-2414	244	1	to	to	PART
admet-2414	244	2	eliminate	eliminate	VERB
admet-2414	244	3	initial	initial	ADJ
admet-2414	244	4	value	value	NOUN
admet-2414	244	5	effects	effect	NOUN
admet-2414	244	6	,	,	PUNCT
admet-2414	244	7	the	the	DET
admet-2414	244	8	dose	dose	NOUN
admet-2414	244	9	is	be	AUX
admet-2414	244	10	given	give	VERB
admet-2414	244	11	for	for	ADP
admet-2414	244	12	two	two	NUM
admet-2414	244	13	days	day	NOUN
admet-2414	244	14	,	,	PUNCT
admet-2414	244	15	and	and	CCONJ
admet-2414	244	16	the	the	DET
admet-2414	244	17	second	second	ADJ
admet-2414	244	18	day	day	NOUN
admet-2414	244	19	results	result	NOUN
admet-2414	244	20	are	be	AUX
admet-2414	244	21	used	use	VERB
admet-2414	244	22	.	.	PUNCT
admet-2414	245	1	table	table	NOUN
admet-2414	245	2	4	4	NUM
admet-2414	245	3	.	.	PUNCT
admet-2414	245	4	glucocorticoid	glucocorticoid	ADJ
admet-2414	245	5	transcription	transcription	NOUN
admet-2414	245	6	quotient	quotient	NOUN
admet-2414	245	7	(	(	PUNCT
admet-2414	245	8	gtq	gtq	PROPN
admet-2414	245	9	)	)	PUNCT
admet-2414	245	10	.	.	PUNCT
admet-2414	246	1	(	(	PUNCT
admet-2414	246	2	q.d	q.d	AUX
admet-2414	246	3	.	.	PUNCT
admet-2414	246	4	=	=	SYM
admet-2414	246	5	one	one	NUM
admet-2414	246	6	dose	dose	VERB
admet-2414	246	7	every	every	DET
admet-2414	246	8	24	24	NUM
admet-2414	246	9	h	h	NOUN
admet-2414	246	10	,	,	PUNCT
admet-2414	246	11	b.i.d	b.i.d	PROPN
admet-2414	246	12	.	.	PUNCT
admet-2414	247	1	=	=	PRON
admet-2414	247	2	one	one	NUM
admet-2414	247	3	dose	dose	VERB
admet-2414	247	4	every	every	DET
admet-2414	247	5	12	12	NUM
admet-2414	247	6	h	h	NOUN
admet-2414	247	7	)	)	PUNCT
admet-2414	247	8	glucocorticoid	glucocorticoid	NOUN
admet-2414	247	9	dose	dose	NOUN
admet-2414	247	10	gtq	gtq	PROPN
admet-2414	247	11	cortisol	cortisol	PROPN
admet-2414	247	12	endogenous	endogenous	ADJ
admet-2414	247	13	0.17	0.17	NUM
admet-2414	247	14	dexamethasone	dexamethasone	NOUN
admet-2414	247	15	1	1	NUM
admet-2414	247	16	mg	mg	NUM
admet-2414	247	17	iv	iv	NUM
admet-2414	247	18	q.d	q.d	PROPN
admet-2414	247	19	.	.	PROPN
admet-2414	247	20	0.29	0.29	NUM
admet-2414	247	21	10	10	NUM
admet-2414	247	22	mg	mg	NUM
admet-2414	247	23	iv	iv	NUM
admet-2414	247	24	q.d	q.d	PROPN
admet-2414	247	25	.	.	PROPN
admet-2414	247	26	0.736	0.736	NUM
admet-2414	247	27	5	5	NUM
admet-2414	247	28	mg	mg	NUM
admet-2414	247	29	iv	iv	NUM
admet-2414	247	30	b.i.d	b.i.d	PROPN
admet-2414	247	31	.	.	PUNCT
admet-2414	248	1	0.788	0.788	NUM
admet-2414	248	2	40	40	NUM
admet-2414	248	3	mg	mg	NUM
admet-2414	248	4	iv	iv	NUM
admet-2414	248	5	q.d	q.d	PROPN
admet-2414	248	6	.	.	PROPN
admet-2414	248	7	0.91	0.91	NUM
admet-2414	248	8	1	1	NUM
admet-2414	248	9	mg	mg	PROPN
admet-2414	248	10	oral	oral	PROPN
admet-2414	248	11	q.d	q.d	PROPN
admet-2414	248	12	.	.	PROPN
admet-2414	248	13	0.29	0.29	NUM
admet-2414	248	14	10	10	NUM
admet-2414	248	15	mg	mg	PROPN
admet-2414	248	16	oral	oral	PROPN
admet-2414	248	17	q.d	q.d	PROPN
admet-2414	248	18	.	.	PROPN
admet-2414	248	19	0.75	0.75	NUM
admet-2414	248	20	40	40	NUM
admet-2414	248	21	mg	mg	PROPN
admet-2414	248	22	oral	oral	PROPN
admet-2414	248	23	q.d	q.d	PROPN
admet-2414	248	24	.	.	PROPN
admet-2414	248	25	0.91	0.91	NUM
admet-2414	248	26	methylprednisolone	methylprednisolone	NOUN
admet-2414	248	27	5	5	NUM
admet-2414	248	28	mg	mg	NOUN
admet-2414	248	29	iv	iv	NUM
admet-2414	248	30	q.d	q.d	PROPN
admet-2414	248	31	.	.	PROPN
admet-2414	248	32	0.19	0.19	NUM
admet-2414	248	33	20	20	NUM
admet-2414	248	34	mg	mg	NOUN
admet-2414	248	35	iv	iv	NUM
admet-2414	248	36	q.d	q.d	NOUN
admet-2414	248	37	0.35	0.35	NUM
admet-2414	248	38	10	10	NUM
admet-2414	248	39	mg	mg	NUM
admet-2414	248	40	iv	iv	NUM
admet-2414	248	41	b.i.d	b.i.d	NOUN
admet-2414	248	42	0.45	0.45	NUM
admet-2414	248	43	80	80	NUM
admet-2414	248	44	mg	mg	NUM
admet-2414	248	45	iv	iv	NUM
admet-2414	248	46	q.d	q.d	PROPN
admet-2414	248	47	.	.	PROPN
admet-2414	248	48	0.54	0.54	NUM
admet-2414	248	49	40	40	NUM
admet-2414	248	50	mg	mg	NUM
admet-2414	248	51	iv	iv	NUM
admet-2414	248	52	b.i.d	b.i.d	NOUN
admet-2414	248	53	.	.	PUNCT
admet-2414	249	1	0.72	0.72	NUM
admet-2414	249	2	320	320	NUM
admet-2414	249	3	mg	mg	NUM
admet-2414	249	4	iv	iv	NUM
admet-2414	249	5	q.d	q.d	PROPN
admet-2414	249	6	.	.	PROPN
admet-2414	249	7	0.73	0.73	NUM
admet-2414	249	8	160	160	NUM
admet-2414	249	9	mg	mg	NUM
admet-2414	249	10	iv	iv	NUM
admet-2414	249	11	b.i.d	b.i.d	NOUN
admet-2414	249	12	.	.	PUNCT
admet-2414	250	1	0.90	0.90	NUM
admet-2414	250	2	prednisone	prednisone	NOUN
admet-2414	250	3	5	5	NUM
admet-2414	250	4	mg	mg	PROPN
admet-2414	250	5	oral	oral	PROPN
admet-2414	250	6	q.d	q.d	PROPN
admet-2414	250	7	.	.	PROPN
admet-2414	250	8	0.24	0.24	NUM
admet-2414	250	9	10	10	NUM
admet-2414	250	10	mg	mg	PROPN
admet-2414	250	11	oral	oral	PROPN
admet-2414	250	12	q.d	q.d	PROPN
admet-2414	250	13	.	.	PROPN
admet-2414	250	14	0.31	0.31	NUM
admet-2414	250	15	5	5	NUM
admet-2414	250	16	mg	mg	NOUN
admet-2414	250	17	oral	oral	ADJ
admet-2414	250	18	b.i.d	b.i.d	PROPN
admet-2414	250	19	.	.	PUNCT
admet-2414	251	1	0.41	0.41	NUM
admet-2414	251	2	20	20	NUM
admet-2414	251	3	mg	mg	PROPN
admet-2414	251	4	oral	oral	PROPN
admet-2414	251	5	q.d	q.d	PROPN
admet-2414	251	6	.	.	PROPN
admet-2414	251	7	0.40	0.40	NUM
admet-2414	251	8	100	100	NUM
admet-2414	251	9	mg	mg	PROPN
admet-2414	251	10	oral	oral	PROPN
admet-2414	251	11	q.d	q.d	PROPN
admet-2414	251	12	.	.	PROPN
admet-2414	251	13	0.60	0.60	NUM
admet-2414	251	14	50	50	NUM
admet-2414	251	15	mg	mg	NOUN
admet-2414	251	16	oral	oral	ADJ
admet-2414	251	17	b.i.d	b.i.d	PROPN
admet-2414	251	18	.	.	PUNCT
admet-2414	252	1	0.81	0.81	NUM
admet-2414	252	2	400	400	NUM
admet-2414	252	3	mg	mg	NOUN
admet-2414	252	4	oral	oral	ADJ
admet-2414	252	5	q.	q.	PROPN
admet-2414	252	6	d.	d.	PROPN
admet-2414	252	7	0.77	0.77	NUM
admet-2414	252	8	dexamethasone	dexamethasone	NOUN
admet-2414	252	9	(	(	PUNCT
admet-2414	252	10	dex	dex	NOUN
admet-2414	252	11	)	)	PUNCT
admet-2414	252	12	has	have	VERB
admet-2414	252	13	the	the	DET
admet-2414	252	14	highest	high	ADJ
admet-2414	252	15	gr	gr	NOUN
admet-2414	252	16	affinity	affinity	NOUN
admet-2414	252	17	(	(	PUNCT
admet-2414	252	18	table	table	NOUN
admet-2414	252	19	1	1	NUM
admet-2414	252	20	)	)	PUNCT
admet-2414	252	21	and	and	CCONJ
admet-2414	252	22	is	be	AUX
admet-2414	252	23	the	the	DET
admet-2414	252	24	longest	long	ADV
admet-2414	252	25	lasting	lasting	ADJ
admet-2414	252	26	(	(	PUNCT
admet-2414	252	27	slowest	slow	ADJ
admet-2414	252	28	clearance	clearance	NOUN
admet-2414	252	29	,	,	PUNCT
admet-2414	252	30	see	see	VERB
admet-2414	252	31	supplement	supplement	NOUN
admet-2414	252	32	ii	ii	PROPN
admet-2414	252	33	)	)	PUNCT
admet-2414	252	34	,	,	PUNCT
admet-2414	252	35	both	both	PRON
admet-2414	252	36	of	of	ADP
admet-2414	252	37	which	which	PRON
admet-2414	252	38	contribute	contribute	VERB
admet-2414	252	39	to	to	ADP
admet-2414	252	40	making	make	VERB
admet-2414	252	41	it	it	PRON
admet-2414	252	42	the	the	DET
admet-2414	252	43	most	most	ADV
admet-2414	252	44	potent	potent	NOUN
admet-2414	252	45	of	of	ADP
admet-2414	252	46	the	the	DET
admet-2414	252	47	commonly	commonly	ADV
admet-2414	252	48	used	use	VERB
admet-2414	252	49	glucocorticoids	glucocorticoid	NOUN
admet-2414	252	50	.	.	PUNCT
admet-2414	253	1	as	as	SCONJ
admet-2414	253	2	discussed	discuss	VERB
admet-2414	253	3	above	above	ADV
admet-2414	253	4	,	,	PUNCT
admet-2414	253	5	it	it	PRON
admet-2414	253	6	is	be	AUX
admet-2414	253	7	the	the	DET
admet-2414	253	8	glucocorticoid	glucocorticoid	NOUN
admet-2414	253	9	of	of	ADP
admet-2414	253	10	choice	choice	NOUN
admet-2414	253	11	for	for	ADP
admet-2414	253	12	most	most	ADJ
admet-2414	253	13	in	in	ADP
admet-2414	253	14	vitro	vitro	X
admet-2414	253	15	experiments	experiment	NOUN
admet-2414	253	16	.	.	PUNCT
admet-2414	254	1	it	it	PRON
admet-2414	254	2	is	be	AUX
admet-2414	254	3	administered	administer	VERB
admet-2414	254	4	either	either	CCONJ
admet-2414	254	5	orally	orally	ADV
admet-2414	254	6	as	as	ADP
admet-2414	254	7	dex	dex	NOUN
admet-2414	254	8	or	or	CCONJ
admet-2414	254	9	iv	iv	NUM
admet-2414	254	10	as	as	ADP
admet-2414	254	11	dex	dex	NOUN
admet-2414	254	12	-	-	PUNCT
admet-2414	254	13	phosphate	phosphate	NOUN
admet-2414	254	14	which	which	PRON
admet-2414	254	15	is	be	AUX
admet-2414	254	16	rapidly	rapidly	ADV
admet-2414	254	17	converted	convert	VERB
admet-2414	254	18	to	to	ADP
admet-2414	254	19	dex	dex	NOUN
admet-2414	254	20	.	.	PUNCT
admet-2414	255	1	dex	dex	PROPN
admet-2414	255	2	has	have	VERB
admet-2414	255	3	simple	simple	ADJ
admet-2414	255	4	linear	linear	ADJ
admet-2414	255	5	pk	pk	NOUN
admet-2414	255	6	with	with	ADP
admet-2414	255	7	a	a	DET
admet-2414	255	8	free	free	ADJ
admet-2414	255	9	plasma	plasma	NOUN
admet-2414	255	10	fraction	fraction	NOUN
admet-2414	255	11	of	of	ADP
admet-2414	255	12	about	about	ADV
admet-2414	255	13	0.23	0.23	NUM
admet-2414	255	14	.	.	PUNCT
admet-2414	256	1	it	it	PRON
admet-2414	256	2	is	be	AUX
admet-2414	256	3	usually	usually	ADV
admet-2414	256	4	administered	administer	VERB
admet-2414	256	5	as	as	ADP
admet-2414	256	6	short	short	ADJ
admet-2414	256	7	-	-	PUNCT
admet-2414	256	8	term	term	NOUN
admet-2414	256	9	therapy	therapy	NOUN
admet-2414	256	10	,	,	PUNCT
admet-2414	256	11	often	often	ADV
admet-2414	256	12	as	as	ADP
admet-2414	256	13	a	a	DET
admet-2414	256	14	“	"	PUNCT
admet-2414	256	15	pulse	pulse	NOUN
admet-2414	256	16	”	"	PUNCT
admet-2414	256	17	,	,	PUNCT
admet-2414	256	18	at	at	ADP
admet-2414	256	19	periodic	periodic	ADJ
admet-2414	256	20	intervals	interval	NOUN
admet-2414	256	21	.	.	PUNCT
admet-2414	257	1	the	the	DET
admet-2414	257	2	dosages	dosage	NOUN
admet-2414	257	3	range	range	VERB
admet-2414	257	4	from	from	ADP
admet-2414	257	5	a	a	DET
admet-2414	257	6	low	low	NOUN
admet-2414	257	7	of	of	ADP
admet-2414	257	8	about	about	ADV
admet-2414	257	9	1	1	NUM
admet-2414	257	10	mg	mg	NUM
admet-2414	257	11	/	/	SYM
admet-2414	257	12	day	day	NOUN
admet-2414	257	13	,	,	PUNCT
admet-2414	257	14	to	to	ADP
admet-2414	257	15	“	"	PUNCT
admet-2414	257	16	high	high	ADJ
admet-2414	257	17	doses	dose	NOUN
admet-2414	257	18	”	"	PUNCT
admet-2414	257	19	of	of	ADP
admet-2414	257	20	40	40	NUM
admet-2414	257	21	mg	mg	NUM
admet-2414	257	22	/	/	SYM
admet-2414	257	23	day	day	NOUN
admet-2414	257	24	.	.	PUNCT
admet-2414	258	1	the	the	DET
admet-2414	258	2	pk	pk	NOUN
admet-2414	258	3	determination	determination	NOUN
admet-2414	258	4	of	of	ADP
admet-2414	258	5	the	the	DET
admet-2414	258	6	plasma	plasma	NOUN
admet-2414	258	7	concentration	concentration	NOUN
admet-2414	258	8	following	follow	VERB
admet-2414	258	9	arbitrary	arbitrary	ADJ
admet-2414	258	10	iv	iv	ADP
admet-2414	258	11	or	or	CCONJ
admet-2414	258	12	oral	oral	ADJ
admet-2414	258	13	doses	dose	NOUN
admet-2414	258	14	is	be	AUX
admet-2414	258	15	described	describe	VERB
admet-2414	258	16	in	in	ADP
admet-2414	258	17	detail	detail	NOUN
admet-2414	258	18	in	in	ADP
admet-2414	258	19	the	the	DET
admet-2414	258	20	attached	attached	ADJ
admet-2414	258	21	file	file	NOUN
admet-2414	258	22	supplement	supplement	PROPN
admet-2414	258	23	ii	ii	PROPN
admet-2414	258	24	.	.	PUNCT
admet-2414	259	1	a	a	DET
admet-2414	259	2	b	b	NOUN
admet-2414	259	3	time	time	NOUN
admet-2414	259	4	,	,	PUNCT
admet-2414	259	5	h	h	NOUN
admet-2414	259	6	time	time	NOUN
admet-2414	259	7	,	,	PUNCT
admet-2414	259	8	h	h	NOUN
admet-2414	259	9	figure	figure	NOUN
admet-2414	259	10	9	9	NUM
admet-2414	259	11	.	.	PUNCT
admet-2414	259	12	dex	dex	NOUN
admet-2414	259	13	gr	gr	NOUN
admet-2414	259	14	activity	activity	NOUN
admet-2414	259	15	following	follow	VERB
admet-2414	259	16	a	a	DET
admet-2414	259	17	-3	-3	INTJ
admet-2414	259	18	q.d	q.d	PROPN
admet-2414	259	19	.	.	PROPN
admet-2414	259	20	and	and	CCONJ
admet-2414	259	21	b.i.d	b.i.d	PROPN
admet-2414	259	22	.	.	PUNCT
admet-2414	260	1	and	and	CCONJ
admet-2414	260	2	b	b	X
admet-2414	260	3	–	–	PUNCT
admet-2414	260	4	3	3	NUM
admet-2414	260	5	oral	oral	ADJ
admet-2414	260	6	g.d	g.d	PROPN
admet-2414	260	7	.	.	PROPN
admet-2414	260	8	doses	dose	NOUN
admet-2414	260	9	per	per	ADP
admet-2414	260	10	day	day	NOUN
admet-2414	261	1	d	d	X
admet-2414	261	2	e	e	X
admet-2414	261	3	xa	xa	PROPN
admet-2414	261	4	m	m	PROPN
admet-2414	261	5	e	e	X
admet-2414	261	6	th	th	X
admet-2414	261	7	as	as	ADP
admet-2414	261	8	o	o	PROPN
admet-2414	261	9	n	n	ADP
admet-2414	261	10	e	e	NOUN
admet-2414	261	11	r	r	NOUN
admet-2414	261	12	e	e	X
admet-2414	261	13	ce	ce	PROPN
admet-2414	261	14	p	p	NOUN
admet-2414	261	15	to	to	ADP
admet-2414	261	16	r	r	VERB
admet-2414	261	17	ac	ac	ADJ
admet-2414	261	18	ti	ti	NOUN
admet-2414	261	19	vi	vi	NOUN
admet-2414	262	1	ty	ty	INTJ
admet-2414	262	2	d	d	X
admet-2414	262	3	e	e	X
admet-2414	262	4	xa	xa	PROPN
admet-2414	262	5	m	m	PROPN
admet-2414	262	6	e	e	X
admet-2414	262	7	th	th	X
admet-2414	262	8	as	as	ADP
admet-2414	262	9	o	o	PROPN
admet-2414	262	10	n	n	ADP
admet-2414	262	11	e	e	NOUN
admet-2414	262	12	r	r	NOUN
admet-2414	262	13	e	e	X
admet-2414	262	14	ce	ce	PROPN
admet-2414	262	15	p	p	NOUN
admet-2414	262	16	to	to	ADP
admet-2414	262	17	r	r	VERB
admet-2414	262	18	ac	ac	ADJ
admet-2414	262	19	ti	ti	PROPN
admet-2414	262	20	vi	vi	NOUN
admet-2414	263	1	ty	ty	NOUN
admet-2414	264	1	admet	admet	PROPN
admet-2414	264	2	&	&	CCONJ
admet-2414	264	3	dmpk	dmpk	PROPN
admet-2414	264	4	12(6	12(6	NUM
admet-2414	264	5	)	)	PUNCT
admet-2414	264	6	(	(	PUNCT
admet-2414	264	7	2024	2024	NUM
admet-2414	264	8	)	)	PUNCT
admet-2414	264	9	971	971	NUM
admet-2414	264	10	-	-	SYM
admet-2414	264	11	989	989	NUM
admet-2414	264	12	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	264	13	/	/	SYM
admet-2414	264	14	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	264	15	of	of	ADP
admet-2414	264	16	glucocorticoids	glucocorticoid	NOUN
admet-2414	264	17	doi	doi	NOUN
admet-2414	264	18	:	:	PUNCT
admet-2414	264	19	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	264	20	983	983	NUM
admet-2414	264	21	figure	figure	NOUN
admet-2414	264	22	9	9	NUM
admet-2414	264	23	shows	show	VERB
admet-2414	264	24	the	the	DET
admet-2414	264	25	gr	gr	NOUN
admet-2414	264	26	transcriptional	transcriptional	ADJ
admet-2414	264	27	activity	activity	NOUN
admet-2414	264	28	of	of	ADP
admet-2414	264	29	varying	vary	VERB
admet-2414	264	30	dosage	dosage	NOUN
admet-2414	264	31	regimens	regimen	NOUN
admet-2414	264	32	of	of	ADP
admet-2414	264	33	either	either	PRON
admet-2414	264	34	iv	iv	NUM
admet-2414	264	35	dex	dex	NOUN
admet-2414	264	36	-	-	PUNCT
admet-2414	264	37	phosphate	phosphate	NOUN
admet-2414	264	38	(	(	PUNCT
admet-2414	264	39	left	leave	VERB
admet-2414	264	40	panel	panel	NOUN
admet-2414	264	41	)	)	PUNCT
admet-2414	264	42	or	or	CCONJ
admet-2414	264	43	oral	oral	ADJ
admet-2414	264	44	dex	dex	NOUN
admet-2414	264	45	(	(	PUNCT
admet-2414	264	46	right	right	ADJ
admet-2414	264	47	panel	panel	NOUN
admet-2414	264	48	)	)	PUNCT
admet-2414	264	49	.	.	PUNCT
admet-2414	265	1	the	the	DET
admet-2414	265	2	gtq	gtq	NOUN
admet-2414	265	3	of	of	ADP
admet-2414	265	4	the	the	DET
admet-2414	265	5	different	different	ADJ
admet-2414	265	6	doses	dose	NOUN
admet-2414	265	7	are	be	AUX
admet-2414	265	8	listed	list	VERB
admet-2414	265	9	in	in	ADP
admet-2414	265	10	table	table	NOUN
admet-2414	265	11	4	4	NUM
admet-2414	265	12	.	.	PUNCT
admet-2414	266	1	the	the	DET
admet-2414	266	2	gtq	gtq	NOUN
admet-2414	266	3	of	of	ADP
admet-2414	266	4	the	the	DET
admet-2414	266	5	“	"	PUNCT
admet-2414	266	6	low	low	ADJ
admet-2414	266	7	”	"	PUNCT
admet-2414	266	8	1	1	NUM
admet-2414	266	9	mg	mg	NOUN
admet-2414	266	10	dose	dose	NOUN
admet-2414	266	11	is	be	AUX
admet-2414	266	12	0.29	0.29	NUM
admet-2414	266	13	,	,	PUNCT
admet-2414	266	14	70	70	NUM
admet-2414	266	15	%	%	NOUN
admet-2414	266	16	greater	great	ADJ
admet-2414	266	17	than	than	ADP
admet-2414	266	18	that	that	PRON
admet-2414	266	19	of	of	ADP
admet-2414	266	20	endogenous	endogenous	ADJ
admet-2414	266	21	cortisol	cortisol	NOUN
admet-2414	266	22	.	.	PUNCT
admet-2414	267	1	the	the	DET
admet-2414	267	2	“	"	PUNCT
admet-2414	267	3	high	high	ADJ
admet-2414	267	4	”	"	PUNCT
admet-2414	267	5	single	single	ADJ
admet-2414	267	6	dose	dose	NOUN
admet-2414	267	7	of	of	ADP
admet-2414	267	8	40	40	NUM
admet-2414	267	9	mg	mg	NOUN
admet-2414	267	10	(	(	PUNCT
admet-2414	267	11	either	either	CCONJ
admet-2414	267	12	iv	iv	ADP
admet-2414	267	13	or	or	CCONJ
admet-2414	267	14	oral	oral	ADJ
admet-2414	267	15	)	)	PUNCT
admet-2414	267	16	nearly	nearly	ADV
admet-2414	267	17	maximizes	maximize	VERB
admet-2414	267	18	the	the	DET
admet-2414	267	19	activity	activity	NOUN
admet-2414	267	20	for	for	ADP
admet-2414	267	21	a	a	DET
admet-2414	267	22	24	24	NUM
admet-2414	267	23	-	-	PUNCT
admet-2414	267	24	hour	hour	NOUN
admet-2414	267	25	period	period	NOUN
admet-2414	267	26	with	with	ADP
admet-2414	267	27	a	a	DET
admet-2414	267	28	gtq	gtq	NOUN
admet-2414	267	29	of	of	ADP
admet-2414	267	30	0.91	0.91	NUM
admet-2414	267	31	.	.	PUNCT
admet-2414	268	1	although	although	SCONJ
admet-2414	268	2	1	1	NUM
admet-2414	268	3	mg	mg	PROPN
admet-2414	268	4	dex	dex	NOUN
admet-2414	268	5	-	-	PUNCT
admet-2414	268	6	phosphate	phosphate	NOUN
admet-2414	268	7	(	(	PUNCT
admet-2414	268	8	mw	mw	X
admet-2414	268	9	472.4	472.4	NUM
admet-2414	268	10	)	)	PUNCT
admet-2414	268	11	is	be	AUX
admet-2414	268	12	equivalent	equivalent	ADJ
admet-2414	268	13	to	to	ADP
admet-2414	268	14	83	83	NUM
admet-2414	268	15	%	%	NOUN
admet-2414	268	16	of	of	ADP
admet-2414	268	17	a	a	DET
admet-2414	268	18	1	1	NUM
admet-2414	268	19	mg	mg	NOUN
admet-2414	268	20	oral	oral	ADJ
admet-2414	268	21	dex	dex	NOUN
admet-2414	268	22	(	(	PUNCT
admet-2414	268	23	mw	mw	VERB
admet-2414	268	24	392.5	392.5	NUM
admet-2414	268	25	)	)	PUNCT
admet-2414	268	26	,	,	PUNCT
admet-2414	268	27	because	because	SCONJ
admet-2414	268	28	the	the	DET
admet-2414	268	29	oral	oral	ADJ
admet-2414	268	30	dex	dex	NOUN
admet-2414	268	31	bioavailability	bioavailability	NOUN
admet-2414	268	32	is	be	AUX
admet-2414	268	33	only	only	ADV
admet-2414	268	34	59	59	NUM
admet-2414	268	35	%	%	NOUN
admet-2414	268	36	,	,	PUNCT
admet-2414	268	37	the	the	DET
admet-2414	268	38	iv	iv	NUM
admet-2414	268	39	dose	dose	NOUN
admet-2414	268	40	represents	represent	VERB
admet-2414	268	41	a	a	DET
admet-2414	268	42	40	40	NUM
admet-2414	268	43	%	%	NOUN
admet-2414	268	44	greater	great	ADJ
admet-2414	268	45	systemic	systemic	ADJ
admet-2414	268	46	dose	dose	NOUN
admet-2414	268	47	.	.	PUNCT
admet-2414	269	1	despite	despite	SCONJ
admet-2414	269	2	this	this	PRON
admet-2414	269	3	,	,	PUNCT
admet-2414	269	4	the	the	DET
admet-2414	269	5	gtq	gtq	NOUN
admet-2414	269	6	of	of	ADP
admet-2414	269	7	the	the	DET
admet-2414	269	8	iv	iv	ADJ
admet-2414	269	9	and	and	CCONJ
admet-2414	269	10	oral	oral	ADJ
admet-2414	269	11	doses	dose	NOUN
admet-2414	269	12	are	be	AUX
admet-2414	269	13	nearly	nearly	ADV
admet-2414	269	14	identical	identical	ADJ
admet-2414	269	15	because	because	SCONJ
admet-2414	269	16	the	the	DET
admet-2414	269	17	slow	slow	ADJ
admet-2414	269	18	oral	oral	ADJ
admet-2414	269	19	dex	dex	NOUN
admet-2414	269	20	absorption	absorption	NOUN
admet-2414	269	21	spreads	spread	VERB
admet-2414	269	22	out	out	ADP
admet-2414	269	23	the	the	DET
admet-2414	269	24	plasma	plasma	NOUN
admet-2414	269	25	dex	dex	NOUN
admet-2414	269	26	over	over	ADP
admet-2414	269	27	a	a	DET
admet-2414	269	28	longer	long	ADJ
admet-2414	269	29	period	period	NOUN
admet-2414	269	30	.	.	PUNCT
admet-2414	270	1	methylprednisolone	methylprednisolone	PROPN
admet-2414	270	2	(	(	PUNCT
admet-2414	270	3	mp	mp	PROPN
admet-2414	270	4	)	)	PUNCT
admet-2414	270	5	is	be	AUX
admet-2414	270	6	a	a	DET
admet-2414	270	7	widely	widely	ADV
admet-2414	270	8	used	use	VERB
admet-2414	270	9	glucocorticoid	glucocorticoid	NOUN
admet-2414	270	10	,	,	PUNCT
admet-2414	270	11	administered	administer	VERB
admet-2414	270	12	either	either	CCONJ
admet-2414	270	13	orally	orally	ADV
admet-2414	270	14	or	or	CCONJ
admet-2414	270	15	intravenously	intravenously	ADV
admet-2414	270	16	(	(	PUNCT
admet-2414	270	17	iv	iv	X
admet-2414	270	18	)	)	PUNCT
admet-2414	270	19	as	as	ADP
admet-2414	270	20	the	the	DET
admet-2414	270	21	acetate	acetate	NOUN
admet-2414	270	22	(	(	PUNCT
admet-2414	270	23	depo	depo	NOUN
admet-2414	270	24	-	-	PUNCT
admet-2414	270	25	medrol	medrol	NOUN
admet-2414	270	26	)	)	PUNCT
admet-2414	270	27	or	or	CCONJ
admet-2414	270	28	succinate	succinate	NOUN
admet-2414	270	29	(	(	PUNCT
admet-2414	270	30	solu	solu	NOUN
admet-2414	270	31	-	-	PUNCT
admet-2414	270	32	medrol	medrol	NOUN
admet-2414	270	33	)	)	PUNCT
admet-2414	270	34	derivative	derivative	NOUN
admet-2414	270	35	.	.	PUNCT
admet-2414	271	1	it	it	PRON
admet-2414	271	2	has	have	VERB
admet-2414	271	3	simple	simple	ADJ
admet-2414	271	4	linear	linear	ADJ
admet-2414	271	5	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	271	6	over	over	ADP
admet-2414	271	7	a	a	DET
admet-2414	271	8	large	large	ADJ
admet-2414	271	9	range	range	NOUN
admet-2414	271	10	of	of	ADP
admet-2414	271	11	dosages	dosage	NOUN
admet-2414	271	12	and	and	CCONJ
admet-2414	271	13	non	non	ADJ
admet-2414	271	14	-	-	ADJ
admet-2414	271	15	saturable	saturable	ADJ
admet-2414	271	16	plasma	plasma	NOUN
admet-2414	271	17	binding	bind	VERB
admet-2414	271	18	with	with	ADP
admet-2414	271	19	a	a	DET
admet-2414	271	20	free	free	ADJ
admet-2414	271	21	fraction	fraction	NOUN
admet-2414	271	22	of	of	ADP
admet-2414	271	23	about	about	ADP
admet-2414	271	24	0.23	0.23	NUM
admet-2414	271	25	.	.	PUNCT
admet-2414	272	1	the	the	DET
admet-2414	272	2	clinical	clinical	ADJ
admet-2414	272	3	methylprednisolone	methylprednisolone	ADJ
admet-2414	272	4	doses	dose	NOUN
admet-2414	272	5	range	range	VERB
admet-2414	272	6	from	from	ADP
admet-2414	272	7	low	low	ADJ
admet-2414	272	8	dosages	dosage	NOUN
admet-2414	272	9	of	of	ADP
admet-2414	272	10	20	20	NUM
admet-2414	272	11	mg	mg	NUM
admet-2414	272	12	/	/	SYM
admet-2414	272	13	day[42	day[42	PROPN
admet-2414	272	14	]	]	PUNCT
admet-2414	272	15	,	,	PUNCT
admet-2414	272	16	to	to	ADP
admet-2414	272	17	high	high	ADJ
admet-2414	272	18	doses	dose	NOUN
admet-2414	272	19	of	of	ADP
admet-2414	272	20	1000	1000	NUM
admet-2414	272	21	mg	mg	NUM
admet-2414	272	22	/	/	SYM
admet-2414	272	23	day	day	NOUN
admet-2414	272	24	or	or	CCONJ
admet-2414	272	25	higher	high	ADJ
admet-2414	272	26	,	,	PUNCT
admet-2414	272	27	usually	usually	ADV
admet-2414	272	28	as	as	ADP
admet-2414	272	29	short	short	ADJ
admet-2414	272	30	term	term	NOUN
admet-2414	272	31	“	"	PUNCT
admet-2414	272	32	pulse	pulse	NOUN
admet-2414	272	33	”	"	PUNCT
admet-2414	272	34	doses	dose	NOUN
admet-2414	272	35	[	[	X
admet-2414	272	36	12,43,44	12,43,44	NUM
admet-2414	272	37	]	]	X
admet-2414	272	38	.	.	PUNCT
admet-2414	273	1	the	the	DET
admet-2414	273	2	detailed	detailed	ADJ
admet-2414	273	3	pk	pk	NOUN
admet-2414	273	4	modeling	modeling	NOUN
admet-2414	273	5	that	that	PRON
admet-2414	273	6	is	be	AUX
admet-2414	273	7	used	use	VERB
admet-2414	273	8	to	to	PART
admet-2414	273	9	predict	predict	VERB
admet-2414	273	10	the	the	DET
admet-2414	273	11	free	free	ADJ
admet-2414	273	12	concentration	concentration	NOUN
admet-2414	273	13	following	follow	VERB
admet-2414	273	14	arbitrary	arbitrary	ADJ
admet-2414	273	15	oral	oral	ADJ
admet-2414	273	16	or	or	CCONJ
admet-2414	273	17	iv	iv	NUM
admet-2414	273	18	doses	dose	NOUN
admet-2414	273	19	is	be	AUX
admet-2414	273	20	described	describe	VERB
admet-2414	273	21	in	in	ADP
admet-2414	273	22	the	the	DET
admet-2414	273	23	attached	attached	ADJ
admet-2414	273	24	file	file	NOUN
admet-2414	273	25	supplement	supplement	PROPN
admet-2414	273	26	ii	ii	PROPN
admet-2414	273	27	.	.	PUNCT
admet-2414	273	28	figure	figure	NOUN
admet-2414	273	29	10	10	NUM
admet-2414	273	30	shows	show	VERB
admet-2414	273	31	the	the	DET
admet-2414	273	32	mp	mp	PROPN
admet-2414	273	33	gr	gr	PRON
admet-2414	273	34	transcriptional	transcriptional	ADJ
admet-2414	273	35	activity	activity	NOUN
admet-2414	273	36	for	for	ADP
admet-2414	273	37	a	a	DET
admet-2414	273	38	total	total	ADJ
admet-2414	273	39	daily	daily	ADJ
admet-2414	273	40	iv	iv	NOUN
admet-2414	273	41	dosage	dosage	NOUN
admet-2414	273	42	of	of	ADP
admet-2414	273	43	5	5	NUM
admet-2414	273	44	mg	mg	NOUN
admet-2414	273	45	(	(	PUNCT
admet-2414	273	46	black	black	NOUN
admet-2414	273	47	)	)	PUNCT
admet-2414	273	48	,	,	PUNCT
admet-2414	273	49	20	20	NUM
admet-2414	273	50	mg	mg	NOUN
admet-2414	273	51	(	(	PUNCT
admet-2414	273	52	red	red	PROPN
admet-2414	273	53	)	)	PUNCT
admet-2414	273	54	,	,	PUNCT
admet-2414	273	55	80	80	NUM
admet-2414	273	56	mg	mg	PROPN
admet-2414	273	57	(	(	PUNCT
admet-2414	273	58	green	green	ADJ
admet-2414	273	59	)	)	PUNCT
admet-2414	273	60	or	or	CCONJ
admet-2414	273	61	320	320	NUM
admet-2414	273	62	mg	mg	NOUN
admet-2414	273	63	(	(	PUNCT
admet-2414	273	64	blue	blue	NOUN
admet-2414	273	65	)	)	PUNCT
admet-2414	273	66	,	,	PUNCT
admet-2414	273	67	given	give	VERB
admet-2414	273	68	as	as	ADV
admet-2414	273	69	once	once	ADV
admet-2414	273	70	/	/	SYM
admet-2414	273	71	day	day	NOUN
admet-2414	273	72	(	(	PUNCT
admet-2414	273	73	q.d	q.d	PROPN
admet-2414	273	74	.	.	PROPN
admet-2414	273	75	,	,	PUNCT
admet-2414	273	76	solid	solid	ADJ
admet-2414	273	77	lines	line	NOUN
admet-2414	273	78	)	)	PUNCT
admet-2414	273	79	,	,	PUNCT
admet-2414	273	80	or	or	CCONJ
admet-2414	273	81	twice	twice	ADV
admet-2414	273	82	/	/	SYM
admet-2414	273	83	day	day	NOUN
admet-2414	273	84	(	(	PUNCT
admet-2414	273	85	b.i.d	b.i.d	PROPN
admet-2414	273	86	.	.	PROPN
admet-2414	273	87	,	,	PUNCT
admet-2414	273	88	dashed	dash	VERB
admet-2414	273	89	lines	line	NOUN
admet-2414	273	90	)	)	PUNCT
admet-2414	273	91	.	.	PUNCT
admet-2414	274	1	table	table	NOUN
admet-2414	274	2	3	3	NUM
admet-2414	274	3	lists	list	VERB
admet-2414	274	4	the	the	DET
admet-2414	274	5	corresponding	corresponding	ADJ
admet-2414	274	6	gtq	gtq	PROPN
admet-2414	274	7	.	.	PUNCT
admet-2414	275	1	the	the	DET
admet-2414	275	2	5	5	NUM
admet-2414	275	3	mg	mg	PROPN
admet-2414	275	4	q.d	q.d	PROPN
admet-2414	275	5	.	.	PROPN
admet-2414	275	6	dose	dose	PROPN
admet-2414	275	7	has	have	VERB
admet-2414	275	8	a	a	DET
admet-2414	275	9	gtq	gtq	NOUN
admet-2414	275	10	of	of	ADP
admet-2414	275	11	0.19	0.19	NUM
admet-2414	275	12	,	,	PUNCT
admet-2414	275	13	12	12	NUM
admet-2414	275	14	%	%	NOUN
admet-2414	275	15	greater	great	ADJ
admet-2414	275	16	than	than	ADP
admet-2414	275	17	endogenous	endogenous	ADJ
admet-2414	275	18	cortisol	cortisol	NOUN
admet-2414	275	19	.	.	PUNCT
admet-2414	276	1	because	because	SCONJ
admet-2414	276	2	of	of	ADP
admet-2414	276	3	the	the	DET
admet-2414	276	4	relatively	relatively	ADV
admet-2414	276	5	short	short	ADJ
admet-2414	276	6	mp	mp	NOUN
admet-2414	276	7	lifetime	lifetime	NOUN
admet-2414	276	8	,	,	PUNCT
admet-2414	276	9	even	even	ADV
admet-2414	276	10	the	the	DET
admet-2414	276	11	highest	high	ADJ
admet-2414	276	12	dose	dose	NOUN
admet-2414	276	13	(	(	PUNCT
admet-2414	276	14	320	320	NUM
admet-2414	276	15	mg	mg	NUM
admet-2414	276	16	/	/	SYM
admet-2414	276	17	day	day	PROPN
admet-2414	276	18	q.d	q.d	PROPN
admet-2414	276	19	.	.	PROPN
admet-2414	276	20	,	,	PUNCT
admet-2414	276	21	solid	solid	ADJ
admet-2414	276	22	blue	blue	ADJ
admet-2414	276	23	line	line	NOUN
admet-2414	276	24	)	)	PUNCT
admet-2414	276	25	has	have	VERB
admet-2414	276	26	a	a	DET
admet-2414	276	27	gtq	gtq	NOUN
admet-2414	276	28	of	of	ADP
admet-2414	276	29	only	only	ADV
admet-2414	276	30	0.73	0.73	NUM
admet-2414	276	31	and	and	CCONJ
admet-2414	276	32	does	do	AUX
admet-2414	276	33	not	not	PART
admet-2414	276	34	fully	fully	ADV
admet-2414	276	35	activate	activate	VERB
admet-2414	276	36	gr	gr	NOUN
admet-2414	276	37	.	.	PUNCT
admet-2414	277	1	dividing	divide	VERB
admet-2414	277	2	this	this	DET
admet-2414	277	3	320	320	NUM
admet-2414	277	4	mg	mg	NOUN
admet-2414	277	5	dose	dose	VERB
admet-2414	277	6	into	into	ADP
admet-2414	277	7	two	two	NUM
admet-2414	277	8	160	160	NUM
admet-2414	277	9	mg	mg	PROPN
admet-2414	277	10	doses	dose	NOUN
admet-2414	277	11	at	at	ADP
admet-2414	277	12	12	12	NUM
admet-2414	277	13	-	-	PUNCT
admet-2414	277	14	hour	hour	NOUN
admet-2414	277	15	intervals	interval	NOUN
admet-2414	277	16	(	(	PUNCT
admet-2414	277	17	b.i.d	b.i.d	PROPN
admet-2414	277	18	,	,	PUNCT
admet-2414	277	19	dashed	dash	VERB
admet-2414	277	20	blue	blue	ADJ
admet-2414	277	21	line	line	NOUN
admet-2414	277	22	.	.	PUNCT
admet-2414	277	23	)	)	PUNCT
admet-2414	278	1	increases	increase	VERB
admet-2414	278	2	gtq	gtq	NOUN
admet-2414	278	3	to	to	ADP
admet-2414	278	4	0.90	0.90	NUM
admet-2414	278	5	.	.	PUNCT
admet-2414	279	1	time	time	NOUN
admet-2414	279	2	,	,	PUNCT
admet-2414	279	3	h	h	NOUN
admet-2414	279	4	figure	figure	NOUN
admet-2414	279	5	10	10	NUM
admet-2414	279	6	.	.	PUNCT
admet-2414	280	1	methylprednisolone	methylprednisolone	ADJ
admet-2414	280	2	gr	gr	PROPN
admet-2414	280	3	activity	activity	NOUN
admet-2414	280	4	prednisone	prednisone	NOUN
admet-2414	280	5	,	,	PUNCT
admet-2414	280	6	which	which	PRON
admet-2414	280	7	is	be	AUX
admet-2414	280	8	only	only	ADV
admet-2414	280	9	administered	administer	VERB
admet-2414	280	10	orally	orally	ADV
admet-2414	280	11	,	,	PUNCT
admet-2414	280	12	is	be	AUX
admet-2414	280	13	the	the	DET
admet-2414	280	14	most	most	ADV
admet-2414	280	15	commonly	commonly	ADV
admet-2414	280	16	prescribed	prescribe	VERB
admet-2414	280	17	glucocorticoid	glucocorticoid	NOUN
admet-2414	280	18	[	[	X
admet-2414	280	19	11	11	NUM
admet-2414	280	20	]	]	PUNCT
admet-2414	280	21	which	which	PRON
admet-2414	280	22	is	be	AUX
admet-2414	280	23	unfortunate	unfortunate	ADJ
admet-2414	280	24	because	because	SCONJ
admet-2414	280	25	,	,	PUNCT
admet-2414	280	26	unlike	unlike	ADP
admet-2414	280	27	dex	dex	NOUN
admet-2414	280	28	and	and	CCONJ
admet-2414	280	29	mp	mp	PROPN
admet-2414	280	30	,	,	PUNCT
admet-2414	280	31	it	it	PRON
admet-2414	280	32	has	have	AUX
admet-2414	280	33	complicated	complicate	VERB
admet-2414	280	34	non	non	ADJ
admet-2414	280	35	-	-	ADJ
admet-2414	280	36	linear	linear	ADJ
admet-2414	280	37	pk	pk	NOUN
admet-2414	280	38	which	which	PRON
admet-2414	280	39	adds	add	VERB
admet-2414	280	40	uncertainty	uncertainty	NOUN
admet-2414	280	41	to	to	ADP
admet-2414	280	42	its	its	PRON
admet-2414	280	43	modeling	modeling	NOUN
admet-2414	280	44	[	[	X
admet-2414	280	45	45	45	NUM
admet-2414	280	46	-	-	SYM
admet-2414	280	47	47	47	NUM
admet-2414	280	48	]	]	PUNCT
admet-2414	280	49	.	.	PUNCT
admet-2414	281	1	it	it	PRON
admet-2414	281	2	is	be	AUX
admet-2414	281	3	a	a	DET
admet-2414	281	4	prodrug	prodrug	NOUN
admet-2414	281	5	that	that	PRON
admet-2414	281	6	is	be	AUX
admet-2414	281	7	converted	convert	VERB
admet-2414	281	8	to	to	ADP
admet-2414	281	9	the	the	DET
admet-2414	281	10	active	active	ADJ
admet-2414	281	11	prednisolone	prednisolone	NOUN
admet-2414	281	12	by	by	ADP
admet-2414	281	13	the	the	DET
admet-2414	281	14	liver	liver	NOUN
admet-2414	281	15	when	when	SCONJ
admet-2414	281	16	it	it	PRON
admet-2414	281	17	is	be	AUX
admet-2414	281	18	absorbed	absorb	VERB
admet-2414	281	19	.	.	PUNCT
admet-2414	282	1	prednisolone	prednisolone	PROPN
admet-2414	282	2	has	have	VERB
admet-2414	282	3	a	a	DET
admet-2414	282	4	high	high	ADJ
admet-2414	282	5	affinity	affinity	NOUN
admet-2414	282	6	binding	bind	VERB
admet-2414	282	7	to	to	ADP
admet-2414	282	8	the	the	DET
admet-2414	282	9	plasma	plasma	NOUN
admet-2414	282	10	protein	protein	NOUN
admet-2414	282	11	transcortin	transcortin	NOUN
admet-2414	282	12	(	(	PUNCT
admet-2414	282	13	also	also	ADV
admet-2414	282	14	known	know	VERB
admet-2414	282	15	as	as	ADP
admet-2414	282	16	corticosteroidbinding	corticosteroidbinde	VERB
admet-2414	282	17	globulin	globulin	NOUN
admet-2414	282	18	(	(	PUNCT
admet-2414	282	19	cbg	cbg	PROPN
admet-2414	282	20	)	)	PUNCT
admet-2414	282	21	)	)	PUNCT
admet-2414	282	22	,	,	PUNCT
admet-2414	282	23	which	which	PRON
admet-2414	282	24	has	have	VERB
admet-2414	282	25	a	a	DET
admet-2414	282	26	limited	limited	ADJ
admet-2414	282	27	binding	bind	VERB
admet-2414	282	28	capacity	capacity	NOUN
admet-2414	282	29	that	that	PRON
admet-2414	282	30	saturates	saturate	VERB
admet-2414	282	31	at	at	ADP
admet-2414	282	32	high	high	ADJ
admet-2414	282	33	prednisolone	prednisolone	NOUN
admet-2414	282	34	concentrations	concentration	NOUN
admet-2414	282	35	.	.	PUNCT
admet-2414	283	1	this	this	PRON
admet-2414	283	2	means	mean	VERB
admet-2414	283	3	that	that	SCONJ
admet-2414	283	4	,	,	PUNCT
admet-2414	283	5	as	as	ADP
admet-2414	283	6	the	the	DET
admet-2414	283	7	concentration	concentration	NOUN
admet-2414	283	8	increases	increase	NOUN
admet-2414	283	9	,	,	PUNCT
admet-2414	283	10	the	the	DET
admet-2414	283	11	unbound	unbound	NOUN
admet-2414	283	12	free	free	ADJ
admet-2414	283	13	fraction	fraction	NOUN
admet-2414	283	14	increases	increase	NOUN
admet-2414	283	15	,	,	PUNCT
admet-2414	283	16	increasing	increase	VERB
admet-2414	283	17	both	both	DET
admet-2414	283	18	the	the	DET
admet-2414	283	19	clearance	clearance	NOUN
admet-2414	283	20	and	and	CCONJ
admet-2414	283	21	the	the	DET
admet-2414	283	22	volume	volume	NOUN
admet-2414	283	23	of	of	ADP
admet-2414	283	24	distribution	distribution	NOUN
admet-2414	283	25	.	.	PUNCT
admet-2414	284	1	further	far	ADV
admet-2414	284	2	complicating	complicate	VERB
admet-2414	284	3	the	the	DET
admet-2414	284	4	kinetics	kinetic	NOUN
admet-2414	284	5	,	,	PUNCT
admet-2414	284	6	the	the	DET
admet-2414	284	7	plasma	plasma	NOUN
admet-2414	284	8	m	m	VERB
admet-2414	284	9	e	e	NOUN
admet-2414	284	10	th	th	X
admet-2414	284	11	yl	yl	NOUN
admet-2414	284	12	p	p	NOUN
admet-2414	284	13	re	re	PROPN
admet-2414	284	14	d	d	PROPN
admet-2414	284	15	n	n	X
admet-2414	284	16	is	be	AUX
admet-2414	284	17	o	o	PROPN
admet-2414	284	18	lo	lo	NOUN
admet-2414	285	1	n	n	NOUN
admet-2414	285	2	e	e	NOUN
admet-2414	285	3	r	r	NOUN
admet-2414	285	4	e	e	X
admet-2414	285	5	ce	ce	PROPN
admet-2414	285	6	p	p	NOUN
admet-2414	285	7	to	to	ADP
admet-2414	285	8	r	r	VERB
admet-2414	285	9	ac	ac	ADJ
admet-2414	285	10	ti	ti	PROPN
admet-2414	285	11	vi	vi	NOUN
admet-2414	285	12	ty	ty	INTJ
admet-2414	285	13	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	285	14	d.	d.	PROPN
admet-2414	285	15	g.	g.	PROPN
admet-2414	285	16	levitt	levitt	PROPN
admet-2414	285	17	admet	admet	PROPN
admet-2414	285	18	&	&	CCONJ
admet-2414	285	19	dmpk	dmpk	PROPN
admet-2414	285	20	12(6	12(6	NUM
admet-2414	285	21	)	)	PUNCT
admet-2414	285	22	(	(	PUNCT
admet-2414	285	23	2024	2024	NUM
admet-2414	285	24	)	)	PUNCT
admet-2414	285	25	971	971	NUM
admet-2414	285	26	-	-	SYM
admet-2414	285	27	989	989	NUM
admet-2414	285	28	984	984	NUM
admet-2414	285	29	prednisone	prednisone	NOUN
admet-2414	285	30	and	and	CCONJ
admet-2414	285	31	prednisolone	prednisolone	PROPN
admet-2414	285	32	are	be	AUX
admet-2414	285	33	continually	continually	ADV
admet-2414	285	34	interconverting	interconverte	VERB
admet-2414	285	35	,	,	PUNCT
admet-2414	285	36	and	and	CCONJ
admet-2414	285	37	the	the	DET
admet-2414	285	38	plasma	plasma	NOUN
admet-2414	285	39	prednisolone	prednisolone	PROPN
admet-2414	285	40	/	/	SYM
admet-2414	285	41	prednisone	prednisone	PROPN
admet-2414	285	42	ratio	ratio	NOUN
admet-2414	285	43	varies	vary	VERB
admet-2414	285	44	non	non	ADJ
admet-2414	285	45	-	-	ADJ
admet-2414	285	46	linearly	linearly	ADV
admet-2414	285	47	over	over	ADP
admet-2414	285	48	a	a	DET
admet-2414	285	49	range	range	NOUN
admet-2414	285	50	of	of	ADP
admet-2414	285	51	2.7	2.7	NUM
admet-2414	285	52	to	to	PART
admet-2414	285	53	10	10	NUM
admet-2414	285	54	,	,	PUNCT
admet-2414	285	55	depending	depend	VERB
admet-2414	285	56	on	on	ADP
admet-2414	285	57	the	the	DET
admet-2414	285	58	prednisolone	prednisolone	PROPN
admet-2414	285	59	concentration	concentration	NOUN
admet-2414	285	60	.	.	PUNCT
admet-2414	286	1	xu	xu	PROPN
admet-2414	286	2	et	et	PROPN
admet-2414	287	1	al	al	PROPN
admet-2414	287	2	.	.	PUNCT
admet-2414	288	1	[	[	X
admet-2414	288	2	47	47	NUM
admet-2414	288	3	]	]	PUNCT
admet-2414	288	4	have	have	AUX
admet-2414	288	5	developed	develop	VERB
admet-2414	288	6	a	a	DET
admet-2414	288	7	kinetic	kinetic	ADJ
admet-2414	288	8	model	model	NOUN
admet-2414	288	9	that	that	PRON
admet-2414	288	10	provides	provide	VERB
admet-2414	288	11	a	a	DET
admet-2414	288	12	good	good	ADJ
admet-2414	288	13	prediction	prediction	NOUN
admet-2414	288	14	of	of	ADP
admet-2414	288	15	the	the	DET
admet-2414	288	16	time	time	NOUN
admet-2414	288	17	course	course	NOUN
admet-2414	288	18	of	of	ADP
admet-2414	288	19	the	the	DET
admet-2414	288	20	free	free	ADJ
admet-2414	288	21	plasma	plasma	NOUN
admet-2414	288	22	prednisolone	prednisolone	NOUN
admet-2414	288	23	concentration	concentration	NOUN
admet-2414	288	24	(	(	PUNCT
admet-2414	288	25	[	[	X
admet-2414	288	26	g	g	X
admet-2414	288	27	]	]	PUNCT
admet-2414	288	28	in	in	ADP
admet-2414	288	29	equation	equation	NOUN
admet-2414	288	30	2	2	NUM
admet-2414	288	31	)	)	PUNCT
admet-2414	288	32	following	follow	VERB
admet-2414	288	33	a	a	DET
admet-2414	288	34	large	large	ADJ
admet-2414	288	35	range	range	NOUN
admet-2414	288	36	of	of	ADP
admet-2414	288	37	oral	oral	ADJ
admet-2414	288	38	prednisone	prednisone	NOUN
admet-2414	288	39	doses	dose	NOUN
admet-2414	288	40	.	.	PUNCT
admet-2414	289	1	the	the	DET
admet-2414	289	2	corresponding	correspond	VERB
admet-2414	289	3	gr	gr	NOUN
admet-2414	289	4	receptor	receptor	NOUN
admet-2414	289	5	activity	activity	NOUN
admet-2414	289	6	is	be	AUX
admet-2414	289	7	obtained	obtain	VERB
admet-2414	289	8	by	by	ADP
admet-2414	289	9	substituting	substitute	VERB
admet-2414	289	10	this	this	DET
admet-2414	289	11	value	value	NOUN
admet-2414	289	12	of	of	ADP
admet-2414	289	13	g	g	NOUN
admet-2414	289	14	into	into	ADP
admet-2414	289	15	equation	equation	NOUN
admet-2414	289	16	(	(	PUNCT
admet-2414	289	17	2	2	NUM
admet-2414	289	18	)	)	PUNCT
admet-2414	289	19	.	.	PUNCT
admet-2414	290	1	the	the	DET
admet-2414	290	2	non	non	ADJ
admet-2414	290	3	-	-	ADJ
admet-2414	290	4	linear	linear	ADJ
admet-2414	290	5	prednisone	prednisone	PROPN
admet-2414	290	6	pk	pk	NOUN
admet-2414	290	7	and	and	CCONJ
admet-2414	290	8	its	its	PRON
admet-2414	290	9	modeling	modeling	NOUN
admet-2414	290	10	is	be	AUX
admet-2414	290	11	discussed	discuss	VERB
admet-2414	290	12	in	in	ADP
admet-2414	290	13	detail	detail	NOUN
admet-2414	290	14	in	in	ADP
admet-2414	290	15	the	the	DET
admet-2414	290	16	attached	attached	ADJ
admet-2414	290	17	file	file	NOUN
admet-2414	290	18	supplement	supplement	PROPN
admet-2414	290	19	ii	ii	PROPN
admet-2414	290	20	.	.	PUNCT
admet-2414	291	1	prednisone	prednisone	PROPN
admet-2414	291	2	doses	dose	NOUN
admet-2414	291	3	range	range	VERB
admet-2414	291	4	from	from	ADP
admet-2414	291	5	lows	low	NOUN
admet-2414	291	6	of	of	ADP
admet-2414	291	7	5	5	NUM
admet-2414	291	8	to	to	PART
admet-2414	291	9	10	10	NUM
admet-2414	291	10	mg	mg	NUM
admet-2414	291	11	/	/	SYM
admet-2414	291	12	day	day	NOUN
admet-2414	291	13	,	,	PUNCT
admet-2414	291	14	medium	medium	ADJ
admet-2414	291	15	doses	dose	NOUN
admet-2414	291	16	of	of	ADP
admet-2414	291	17	about	about	ADV
admet-2414	291	18	20	20	NUM
admet-2414	291	19	mg	mg	NUM
admet-2414	291	20	/	/	SYM
admet-2414	291	21	day	day	NOUN
admet-2414	291	22	,	,	PUNCT
admet-2414	291	23	high	high	ADJ
admet-2414	291	24	doses	dose	NOUN
admet-2414	291	25	of	of	ADP
admet-2414	291	26	100	100	NUM
admet-2414	291	27	mg	mg	NUM
admet-2414	291	28	/	/	SYM
admet-2414	291	29	day	day	NOUN
admet-2414	291	30	to	to	ADP
admet-2414	291	31	very	very	ADV
admet-2414	291	32	high	high	ADJ
admet-2414	291	33	pulse	pulse	NOUN
admet-2414	291	34	doses	dose	NOUN
admet-2414	291	35	to	to	ADP
admet-2414	291	36	250	250	NUM
admet-2414	291	37	mg	mg	NUM
admet-2414	291	38	/	/	SYM
admet-2414	291	39	day	day	NOUN
admet-2414	291	40	or	or	CCONJ
admet-2414	291	41	greater	great	ADJ
admet-2414	291	42	[	[	X
admet-2414	291	43	48	48	NUM
admet-2414	291	44	]	]	PUNCT
admet-2414	291	45	.	.	PUNCT
admet-2414	292	1	figure	figure	NOUN
admet-2414	292	2	11	11	NUM
admet-2414	292	3	shows	show	VERB
admet-2414	292	4	the	the	DET
admet-2414	292	5	gr	gr	NOUN
admet-2414	292	6	receptor	receptor	NOUN
admet-2414	292	7	activity	activity	NOUN
admet-2414	292	8	following	follow	VERB
admet-2414	292	9	oral	oral	ADJ
admet-2414	292	10	doses	dose	NOUN
admet-2414	292	11	ranging	range	VERB
admet-2414	292	12	from	from	ADP
admet-2414	292	13	5	5	NUM
admet-2414	292	14	to	to	PART
admet-2414	292	15	400	400	NUM
admet-2414	292	16	mg	mg	NUM
admet-2414	292	17	/	/	SYM
admet-2414	292	18	day	day	NOUN
admet-2414	292	19	.	.	PUNCT
admet-2414	293	1	because	because	SCONJ
admet-2414	293	2	the	the	DET
admet-2414	293	3	low	low	ADJ
admet-2414	293	4	prednisone	prednisone	NOUN
admet-2414	293	5	doses	dose	NOUN
admet-2414	293	6	are	be	AUX
admet-2414	293	7	often	often	ADV
admet-2414	293	8	administered	administer	VERB
admet-2414	293	9	chronically	chronically	ADV
admet-2414	293	10	for	for	ADP
admet-2414	293	11	long	long	ADJ
admet-2414	293	12	periods	period	NOUN
admet-2414	293	13	,	,	PUNCT
admet-2414	293	14	it	it	PRON
admet-2414	293	15	is	be	AUX
admet-2414	293	16	of	of	ADP
admet-2414	293	17	particular	particular	ADJ
admet-2414	293	18	interest	interest	NOUN
admet-2414	293	19	to	to	PART
admet-2414	293	20	compare	compare	VERB
admet-2414	293	21	their	their	PRON
admet-2414	293	22	action	action	NOUN
admet-2414	293	23	with	with	ADP
admet-2414	293	24	that	that	PRON
admet-2414	293	25	of	of	ADP
admet-2414	293	26	endogenous	endogenous	ADJ
admet-2414	293	27	cortisol	cortisol	NOUN
admet-2414	293	28	.	.	PUNCT
admet-2414	294	1	although	although	SCONJ
admet-2414	294	2	the	the	DET
admet-2414	294	3	5mg	5mg	ADJ
admet-2414	294	4	/	/	SYM
admet-2414	294	5	day	day	NOUN
admet-2414	294	6	dose	dose	NOUN
admet-2414	294	7	(	(	PUNCT
admet-2414	294	8	black	black	ADJ
admet-2414	294	9	line	line	NOUN
admet-2414	294	10	)	)	PUNCT
admet-2414	294	11	is	be	AUX
admet-2414	294	12	usually	usually	ADV
admet-2414	294	13	considered	consider	VERB
admet-2414	294	14	“	"	PUNCT
admet-2414	294	15	physiological	physiological	ADJ
admet-2414	294	16	”	"	PUNCT
admet-2414	294	17	,	,	PUNCT
admet-2414	294	18	it	it	PRON
admet-2414	294	19	has	have	VERB
admet-2414	294	20	a	a	DET
admet-2414	294	21	gtq	gtq	NOUN
admet-2414	294	22	of	of	ADP
admet-2414	294	23	0.24	0.24	NUM
admet-2414	294	24	,	,	PUNCT
admet-2414	294	25	41	41	NUM
admet-2414	294	26	%	%	NOUN
admet-2414	294	27	greater	great	ADJ
admet-2414	294	28	than	than	ADP
admet-2414	294	29	that	that	PRON
admet-2414	294	30	of	of	ADP
admet-2414	294	31	endogenous	endogenous	ADJ
admet-2414	294	32	cortisol	cortisol	NOUN
admet-2414	294	33	.	.	PUNCT
admet-2414	295	1	in	in	ADP
admet-2414	295	2	addition	addition	NOUN
admet-2414	295	3	,	,	PUNCT
admet-2414	295	4	it	it	PRON
admet-2414	295	5	has	have	VERB
admet-2414	295	6	a	a	DET
admet-2414	295	7	significantly	significantly	ADV
admet-2414	295	8	different	different	ADJ
admet-2414	295	9	time	time	NOUN
admet-2414	295	10	course	course	NOUN
admet-2414	295	11	,	,	PUNCT
admet-2414	295	12	rising	rise	VERB
admet-2414	295	13	to	to	ADP
admet-2414	295	14	a	a	DET
admet-2414	295	15	peak	peak	NOUN
admet-2414	295	16	activation	activation	NOUN
admet-2414	295	17	of	of	ADP
admet-2414	295	18	0.76	0.76	NUM
admet-2414	295	19	,	,	PUNCT
admet-2414	295	20	nearly	nearly	ADV
admet-2414	295	21	twice	twice	DET
admet-2414	295	22	the	the	DET
admet-2414	295	23	peak	peak	NOUN
admet-2414	295	24	of	of	ADP
admet-2414	295	25	0.39	0.39	NUM
admet-2414	295	26	for	for	ADP
admet-2414	295	27	endogenous	endogenous	ADJ
admet-2414	295	28	cortisol	cortisol	NOUN
admet-2414	295	29	(	(	PUNCT
admet-2414	295	30	figure	figure	NOUN
admet-2414	295	31	8)	8)	NUM
admet-2414	295	32	.	.	PUNCT
admet-2414	296	1	because	because	SCONJ
admet-2414	296	2	of	of	ADP
admet-2414	296	3	its	its	PRON
admet-2414	296	4	relatively	relatively	ADV
admet-2414	296	5	rapid	rapid	ADJ
admet-2414	296	6	clearance	clearance	NOUN
admet-2414	296	7	,	,	PUNCT
admet-2414	296	8	even	even	ADV
admet-2414	296	9	a	a	DET
admet-2414	296	10	400	400	NUM
admet-2414	296	11	mg	mg	NOUN
admet-2414	296	12	q.d	q.d	NOUN
admet-2414	296	13	dose	dose	NOUN
admet-2414	296	14	only	only	ADV
admet-2414	296	15	has	have	VERB
admet-2414	296	16	a	a	DET
admet-2414	296	17	gtq	gtq	NOUN
admet-2414	296	18	of	of	ADP
admet-2414	296	19	0.77	0.77	NUM
admet-2414	296	20	.	.	PUNCT
admet-2414	297	1	dividing	divide	VERB
admet-2414	297	2	the	the	DET
admet-2414	297	3	dose	dose	NOUN
admet-2414	297	4	into	into	ADP
admet-2414	297	5	two	two	NUM
admet-2414	297	6	b.i.d	b.i.d	NOUN
admet-2414	297	7	.	.	PUNCT
admet-2414	298	1	doses	dose	NOUN
admet-2414	298	2	significantly	significantly	ADV
admet-2414	298	3	increases	increase	VERB
admet-2414	298	4	the	the	DET
admet-2414	298	5	activity	activity	NOUN
admet-2414	298	6	.	.	PUNCT
admet-2414	299	1	for	for	ADP
admet-2414	299	2	example	example	NOUN
admet-2414	299	3	,	,	PUNCT
admet-2414	299	4	100	100	NUM
admet-2414	299	5	mg	mg	NOUN
admet-2414	299	6	given	give	VERB
admet-2414	299	7	as	as	ADP
admet-2414	299	8	two	two	NUM
admet-2414	299	9	50	50	NUM
admet-2414	299	10	mg	mg	NOUN
admet-2414	299	11	doses	dose	NOUN
admet-2414	299	12	(	(	PUNCT
admet-2414	299	13	red	red	ADJ
admet-2414	299	14	dashed	dash	VERB
admet-2414	299	15	line	line	NOUN
admet-2414	299	16	)	)	PUNCT
admet-2414	299	17	has	have	VERB
admet-2414	299	18	a	a	DET
admet-2414	299	19	greater	great	ADJ
admet-2414	299	20	gtq	gtq	NOUN
admet-2414	299	21	than	than	ADP
admet-2414	299	22	400	400	NUM
admet-2414	299	23	mg	mg	PROPN
admet-2414	299	24	q.d	q.d	PROPN
admet-2414	299	25	.	.	PROPN
admet-2414	299	26	time	time	NOUN
admet-2414	299	27	,	,	PUNCT
admet-2414	299	28	h	h	NOUN
admet-2414	299	29	figure	figure	NOUN
admet-2414	299	30	11	11	NUM
admet-2414	299	31	.	.	PUNCT
admet-2414	300	1	prednisone	prednisone	NOUN
admet-2414	300	2	gr	gr	NOUN
admet-2414	300	3	activity	activity	NOUN
admet-2414	300	4	conclusion	conclusion	NOUN
admet-2414	300	5	although	although	SCONJ
admet-2414	300	6	the	the	DET
admet-2414	300	7	main	main	ADJ
admet-2414	300	8	qualitative	qualitative	ADJ
admet-2414	300	9	features	feature	NOUN
admet-2414	300	10	of	of	ADP
admet-2414	300	11	the	the	DET
admet-2414	300	12	glucocorticoid	glucocorticoid	ADJ
admet-2414	300	13	receptor	receptor	NOUN
admet-2414	300	14	(	(	PUNCT
admet-2414	300	15	gr	gr	NOUN
admet-2414	300	16	)	)	PUNCT
admet-2414	300	17	dynamics	dynamic	NOUN
admet-2414	300	18	have	have	AUX
admet-2414	300	19	been	be	AUX
admet-2414	300	20	understood	understand	VERB
admet-2414	300	21	for	for	ADP
admet-2414	300	22	nearly	nearly	ADV
admet-2414	300	23	50	50	NUM
admet-2414	300	24	years	year	NOUN
admet-2414	300	25	,	,	PUNCT
admet-2414	300	26	there	there	PRON
admet-2414	300	27	has	have	AUX
admet-2414	300	28	not	not	PART
admet-2414	300	29	been	be	AUX
admet-2414	300	30	a	a	DET
admet-2414	300	31	previous	previous	ADJ
admet-2414	300	32	attempt	attempt	NOUN
admet-2414	300	33	to	to	PART
admet-2414	300	34	quantitively	quantitively	ADV
admet-2414	300	35	model	model	VERB
admet-2414	300	36	the	the	DET
admet-2414	300	37	gr	gr	PROPN
admet-2414	300	38	dynamics	dynamic	NOUN
admet-2414	300	39	.	.	PUNCT
admet-2414	301	1	the	the	DET
admet-2414	301	2	kinetic	kinetic	ADJ
admet-2414	301	3	model	model	NOUN
admet-2414	301	4	described	describe	VERB
admet-2414	301	5	in	in	ADP
admet-2414	301	6	figure	figure	NOUN
admet-2414	301	7	1	1	NUM
admet-2414	301	8	is	be	AUX
admet-2414	301	9	,	,	PUNCT
admet-2414	301	10	seemingly	seemingly	ADV
admet-2414	301	11	,	,	PUNCT
admet-2414	301	12	the	the	DET
admet-2414	301	13	minimal	minimal	ADJ
admet-2414	301	14	one	one	NOUN
admet-2414	301	15	that	that	PRON
admet-2414	301	16	incorporates	incorporate	VERB
admet-2414	301	17	all	all	DET
admet-2414	301	18	the	the	DET
admet-2414	301	19	essential	essential	ADJ
admet-2414	301	20	features	feature	NOUN
admet-2414	301	21	.	.	PUNCT
admet-2414	302	1	unquestionably	unquestionably	ADV
admet-2414	302	2	,	,	PUNCT
admet-2414	302	3	it	it	PRON
admet-2414	302	4	is	be	AUX
admet-2414	302	5	an	an	DET
admet-2414	302	6	oversimplification	oversimplification	NOUN
admet-2414	302	7	of	of	ADP
admet-2414	302	8	the	the	DET
admet-2414	302	9	true	true	ADJ
admet-2414	302	10	kinetics	kinetic	NOUN
admet-2414	302	11	,	,	PUNCT
admet-2414	302	12	but	but	CCONJ
admet-2414	302	13	it	it	PRON
admet-2414	302	14	is	be	AUX
admet-2414	302	15	hoped	hope	VERB
admet-2414	302	16	that	that	SCONJ
admet-2414	302	17	it	it	PRON
admet-2414	302	18	captures	capture	VERB
admet-2414	302	19	the	the	DET
admet-2414	302	20	main	main	ADJ
admet-2414	302	21	features	feature	NOUN
admet-2414	302	22	.	.	PUNCT
admet-2414	303	1	because	because	SCONJ
admet-2414	303	2	the	the	DET
admet-2414	303	3	model	model	NOUN
admet-2414	303	4	parameters	parameter	NOUN
admet-2414	303	5	are	be	AUX
admet-2414	303	6	only	only	ADV
admet-2414	303	7	roughly	roughly	ADV
admet-2414	303	8	constrained	constrain	VERB
admet-2414	303	9	by	by	ADP
admet-2414	303	10	experimental	experimental	ADJ
admet-2414	303	11	data	datum	NOUN
admet-2414	303	12	,	,	PUNCT
admet-2414	303	13	the	the	DET
admet-2414	303	14	quantitative	quantitative	ADJ
admet-2414	303	15	results	result	NOUN
admet-2414	303	16	described	describe	VERB
admet-2414	303	17	above	above	ADV
admet-2414	303	18	should	should	AUX
admet-2414	303	19	only	only	ADV
admet-2414	303	20	be	be	AUX
admet-2414	303	21	regarded	regard	VERB
admet-2414	303	22	as	as	ADP
admet-2414	303	23	first	first	ADJ
admet-2414	303	24	approximations	approximation	NOUN
admet-2414	303	25	.	.	PUNCT
admet-2414	304	1	it	it	PRON
admet-2414	304	2	is	be	AUX
admet-2414	304	3	hoped	hope	VERB
admet-2414	304	4	that	that	SCONJ
admet-2414	304	5	this	this	DET
admet-2414	304	6	model	model	NOUN
admet-2414	304	7	may	may	AUX
admet-2414	304	8	stimulate	stimulate	VERB
admet-2414	304	9	more	more	ADV
admet-2414	304	10	detailed	detailed	ADJ
admet-2414	304	11	investigations	investigation	NOUN
admet-2414	304	12	of	of	ADP
admet-2414	304	13	these	these	DET
admet-2414	304	14	parameters	parameter	NOUN
admet-2414	304	15	.	.	PUNCT
admet-2414	305	1	p	p	X
admet-2414	306	1	re	re	X
admet-2414	306	2	d	d	PROPN
admet-2414	306	3	n	n	X
admet-2414	306	4	is	be	AUX
admet-2414	306	5	o	o	PROPN
admet-2414	306	6	n	n	ADP
admet-2414	306	7	e	e	NOUN
admet-2414	306	8	r	r	NOUN
admet-2414	306	9	e	e	X
admet-2414	306	10	ce	ce	PROPN
admet-2414	306	11	p	p	NOUN
admet-2414	306	12	to	to	ADP
admet-2414	306	13	r	r	VERB
admet-2414	306	14	ac	ac	ADJ
admet-2414	306	15	ti	ti	PROPN
admet-2414	306	16	vi	vi	NOUN
admet-2414	307	1	ty	ty	NOUN
admet-2414	307	2	admet	admet	PROPN
admet-2414	307	3	&	&	CCONJ
admet-2414	307	4	dmpk	dmpk	PROPN
admet-2414	307	5	12(6	12(6	NUM
admet-2414	307	6	)	)	PUNCT
admet-2414	307	7	(	(	PUNCT
admet-2414	307	8	2024	2024	NUM
admet-2414	307	9	)	)	PUNCT
admet-2414	307	10	971	971	NUM
admet-2414	307	11	-	-	SYM
admet-2414	307	12	989	989	NUM
admet-2414	307	13	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	307	14	/	/	SYM
admet-2414	307	15	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	307	16	of	of	ADP
admet-2414	307	17	glucocorticoids	glucocorticoid	NOUN
admet-2414	307	18	doi	doi	NOUN
admet-2414	307	19	:	:	PUNCT
admet-2414	307	20	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	307	21	985	985	NUM
admet-2414	307	22	in	in	ADP
admet-2414	307	23	the	the	DET
admet-2414	307	24	presence	presence	NOUN
admet-2414	307	25	of	of	ADP
admet-2414	307	26	moderate	moderate	ADJ
admet-2414	307	27	g	g	NOUN
admet-2414	307	28	concentrations	concentration	NOUN
admet-2414	307	29	,	,	PUNCT
admet-2414	307	30	gr	gr	PROPN
admet-2414	307	31	is	be	AUX
admet-2414	307	32	predominantly	predominantly	ADV
admet-2414	307	33	recycling	recycle	VERB
admet-2414	307	34	in	in	ADP
admet-2414	307	35	the	the	DET
admet-2414	307	36	nucleus	nucleus	NOUN
admet-2414	307	37	without	without	ADP
admet-2414	307	38	reentering	reentere	VERB
admet-2414	307	39	the	the	DET
admet-2414	307	40	cytoplasm	cytoplasm	NOUN
admet-2414	307	41	(	(	PUNCT
admet-2414	307	42	figure1	figure1	PROPN
admet-2414	307	43	)	)	PUNCT
admet-2414	307	44	.	.	PUNCT
admet-2414	308	1	in	in	ADP
admet-2414	308	2	this	this	DET
admet-2414	308	3	concentration	concentration	NOUN
admet-2414	308	4	range	range	NOUN
admet-2414	308	5	,	,	PUNCT
admet-2414	308	6	the	the	DET
admet-2414	308	7	activity	activity	NOUN
admet-2414	308	8	is	be	AUX
admet-2414	308	9	described	describe	VERB
admet-2414	308	10	by	by	ADP
admet-2414	308	11	the	the	DET
admet-2414	308	12	standard	standard	ADJ
admet-2414	308	13	michaelis	michaeli	NOUN
admet-2414	308	14	-	-	PUNCT
admet-2414	308	15	menten	menten	ADJ
admet-2414	308	16	equation	equation	NOUN
admet-2414	308	17	(	(	PUNCT
admet-2414	308	18	3	3	NUM
admet-2414	308	19	)	)	PUNCT
admet-2414	308	20	with	with	ADP
admet-2414	308	21	a	a	DET
admet-2414	308	22	km	km	NOUN
admet-2414	308	23	equal	equal	ADJ
admet-2414	308	24	to	to	ADP
admet-2414	308	25	the	the	DET
admet-2414	308	26	kmt	kmt	PROPN
admet-2414	308	27	determined	determine	VERB
admet-2414	308	28	experimentally	experimentally	ADV
admet-2414	308	29	from	from	ADP
admet-2414	308	30	the	the	DET
admet-2414	308	31	concentration	concentration	NOUN
admet-2414	308	32	dependence	dependence	NOUN
admet-2414	308	33	of	of	ADP
admet-2414	308	34	transcriptional	transcriptional	ADJ
admet-2414	308	35	modulation	modulation	NOUN
admet-2414	308	36	.	.	PUNCT
admet-2414	309	1	one	one	NUM
admet-2414	309	2	implication	implication	NOUN
admet-2414	309	3	of	of	ADP
admet-2414	309	4	this	this	PRON
admet-2414	309	5	is	be	AUX
admet-2414	309	6	that	that	SCONJ
admet-2414	309	7	,	,	PUNCT
admet-2414	309	8	over	over	ADP
admet-2414	309	9	most	most	ADJ
admet-2414	309	10	of	of	ADP
admet-2414	309	11	the	the	DET
admet-2414	309	12	operational	operational	ADJ
admet-2414	309	13	g	g	PROPN
admet-2414	309	14	concentration	concentration	NOUN
admet-2414	309	15	range	range	NOUN
admet-2414	309	16	,	,	PUNCT
admet-2414	309	17	the	the	DET
admet-2414	309	18	gr	gr	NOUN
admet-2414	309	19	transcriptional	transcriptional	ADJ
admet-2414	309	20	activity	activity	NOUN
admet-2414	309	21	kmt	kmt	PROPN
admet-2414	309	22	should	should	AUX
admet-2414	309	23	be	be	AUX
admet-2414	309	24	independent	independent	ADJ
admet-2414	309	25	of	of	ADP
admet-2414	309	26	the	the	DET
admet-2414	309	27	affinity	affinity	NOUN
admet-2414	309	28	of	of	ADP
admet-2414	309	29	the	the	DET
admet-2414	309	30	cytosolic	cytosolic	ADJ
admet-2414	309	31	free	free	ADJ
admet-2414	309	32	receptor	receptor	NOUN
admet-2414	309	33	kc	kc	PROPN
admet-2414	309	34	.	.	PUNCT
admet-2414	310	1	this	this	PRON
admet-2414	310	2	is	be	AUX
admet-2414	310	3	supported	support	VERB
admet-2414	310	4	by	by	ADP
admet-2414	310	5	the	the	DET
admet-2414	310	6	results	result	NOUN
admet-2414	310	7	of	of	ADP
admet-2414	310	8	mercier	merci	ADJ
admet-2414	310	9	et	et	NOUN
admet-2414	310	10	.	.	PUNCT
admet-2414	311	1	al.[25	al.[25	PROPN
admet-2414	311	2	]	]	PUNCT
admet-2414	311	3	who	who	PRON
admet-2414	311	4	reported	report	VERB
admet-2414	311	5	that	that	SCONJ
admet-2414	311	6	two	two	NUM
admet-2414	311	7	derived	derive	VERB
admet-2414	311	8	hepatoma	hepatoma	NOUN
admet-2414	311	9	cell	cell	NOUN
admet-2414	311	10	lines	line	NOUN
admet-2414	311	11	had	have	VERB
admet-2414	311	12	about	about	ADV
admet-2414	311	13	a	a	DET
admet-2414	311	14	7	7	NUM
admet-2414	311	15	-	-	ADJ
admet-2414	311	16	fold	fold	ADJ
admet-2414	311	17	difference	difference	NOUN
admet-2414	311	18	in	in	ADP
admet-2414	311	19	kmt	kmt	PROPN
admet-2414	311	20	,	,	PUNCT
admet-2414	311	21	despite	despite	SCONJ
admet-2414	311	22	having	have	VERB
admet-2414	311	23	identical	identical	ADJ
admet-2414	311	24	kc	kc	PROPN
admet-2414	311	25	(	(	PUNCT
admet-2414	311	26	measured	measure	VERB
admet-2414	311	27	at	at	ADP
admet-2414	311	28	0	0	NUM
admet-2414	311	29	°	°	NOUN
admet-2414	311	30	c	c	NOUN
admet-2414	311	31	)	)	PUNCT
admet-2414	311	32	.	.	PUNCT
admet-2414	312	1	the	the	DET
admet-2414	312	2	kmt	kmt	PROPN
admet-2414	312	3	varies	vary	VERB
admet-2414	312	4	by	by	ADP
admet-2414	312	5	a	a	DET
admet-2414	312	6	factor	factor	NOUN
admet-2414	312	7	of	of	ADP
admet-2414	312	8	as	as	ADV
admet-2414	312	9	much	much	ADJ
admet-2414	312	10	as	as	ADP
admet-2414	312	11	10	10	NUM
admet-2414	312	12	for	for	ADP
admet-2414	312	13	different	different	ADJ
admet-2414	312	14	cell	cell	NOUN
admet-2414	312	15	line	line	NOUN
admet-2414	312	16	systems	system	NOUN
admet-2414	312	17	(	(	PUNCT
admet-2414	312	18	table	table	NOUN
admet-2414	312	19	2	2	NUM
admet-2414	312	20	)	)	PUNCT
admet-2414	312	21	.	.	PUNCT
admet-2414	313	1	it	it	PRON
admet-2414	313	2	is	be	AUX
admet-2414	313	3	usually	usually	ADV
admet-2414	313	4	assumed	assume	VERB
admet-2414	313	5	that	that	SCONJ
admet-2414	313	6	this	this	DET
admet-2414	313	7	variation	variation	NOUN
admet-2414	313	8	is	be	AUX
admet-2414	313	9	a	a	DET
admet-2414	313	10	result	result	NOUN
admet-2414	313	11	of	of	ADP
admet-2414	313	12	variations	variation	NOUN
admet-2414	313	13	in	in	ADP
admet-2414	313	14	the	the	DET
admet-2414	313	15	binding	bind	VERB
admet-2414	313	16	affinities	affinity	NOUN
admet-2414	313	17	kc	kc	PROPN
admet-2414	313	18	or	or	CCONJ
admet-2414	313	19	kn	kn	PROPN
admet-2414	313	20	.	.	PUNCT
admet-2414	314	1	however	however	ADV
admet-2414	314	2	,	,	PUNCT
admet-2414	314	3	kmt	kmt	PROPN
admet-2414	314	4	(=	(=	NOUN
admet-2414	314	5	kmh	kmh	PROPN
admet-2414	314	6	)	)	PUNCT
admet-2414	314	7	depends	depend	VERB
admet-2414	314	8	not	not	PART
admet-2414	314	9	only	only	ADV
admet-2414	314	10	on	on	ADP
admet-2414	314	11	kn	kn	PROPN
admet-2414	314	12	,	,	PUNCT
admet-2414	314	13	but	but	CCONJ
admet-2414	314	14	also	also	ADV
admet-2414	314	15	on	on	SCONJ
admet-2414	314	16	the	the	DET
admet-2414	314	17	three	three	NUM
admet-2414	314	18	rate	rate	NOUN
admet-2414	314	19	constants	constant	NOUN
admet-2414	314	20	k3	k3	VERB
admet-2414	314	21	,	,	PUNCT
admet-2414	314	22	k4	k4	NOUN
admet-2414	314	23	and	and	CCONJ
admet-2414	314	24	k6	k6	NOUN
admet-2414	314	25	(	(	PUNCT
admet-2414	314	26	equation	equation	NOUN
admet-2414	314	27	(	(	PUNCT
admet-2414	314	28	3	3	NUM
admet-2414	314	29	)	)	PUNCT
admet-2414	314	30	)	)	PUNCT
admet-2414	314	31	and	and	CCONJ
admet-2414	314	32	variations	variation	NOUN
admet-2414	314	33	in	in	ADP
admet-2414	314	34	any	any	PRON
admet-2414	314	35	of	of	ADP
admet-2414	314	36	these	these	DET
admet-2414	314	37	4	4	NUM
admet-2414	314	38	parameters	parameter	NOUN
admet-2414	314	39	could	could	AUX
admet-2414	314	40	account	account	VERB
admet-2414	314	41	for	for	ADP
admet-2414	314	42	the	the	DET
admet-2414	314	43	cell	cell	NOUN
admet-2414	314	44	line	line	NOUN
admet-2414	314	45	differences	difference	NOUN
admet-2414	314	46	.	.	PUNCT
admet-2414	315	1	a	a	DET
admet-2414	315	2	novel	novel	ADJ
admet-2414	315	3	result	result	NOUN
admet-2414	315	4	of	of	ADP
admet-2414	315	5	the	the	DET
admet-2414	315	6	kinetic	kinetic	ADJ
admet-2414	315	7	analysis	analysis	NOUN
admet-2414	315	8	is	be	AUX
admet-2414	315	9	that	that	SCONJ
admet-2414	315	10	,	,	PUNCT
admet-2414	315	11	at	at	ADP
admet-2414	315	12	very	very	ADV
admet-2414	315	13	low	low	ADJ
admet-2414	315	14	g	g	NOUN
admet-2414	315	15	concentrations	concentration	NOUN
admet-2414	315	16	,	,	PUNCT
admet-2414	315	17	the	the	DET
admet-2414	315	18	gr	gr	NOUN
admet-2414	315	19	activity	activity	NOUN
admet-2414	315	20	is	be	AUX
admet-2414	315	21	described	describe	VERB
admet-2414	315	22	by	by	ADP
admet-2414	315	23	the	the	DET
admet-2414	315	24	michaelis	michaelis	ADJ
admet-2414	315	25	-	-	PUNCT
admet-2414	315	26	menten	menten	ADJ
admet-2414	315	27	equation	equation	NOUN
admet-2414	315	28	(	(	PUNCT
admet-2414	315	29	4	4	NUM
admet-2414	315	30	)	)	PUNCT
admet-2414	315	31	with	with	ADP
admet-2414	315	32	an	an	DET
admet-2414	315	33	extremely	extremely	ADV
admet-2414	315	34	high	high	ADJ
admet-2414	315	35	apparent	apparent	ADJ
admet-2414	315	36	affinity	affinity	NOUN
admet-2414	315	37	kml	kml	NOUN
admet-2414	315	38	(	(	PUNCT
admet-2414	315	39	table	table	NOUN
admet-2414	315	40	3	3	NUM
admet-2414	315	41	)	)	PUNCT
admet-2414	315	42	.	.	PUNCT
admet-2414	316	1	this	this	DET
admet-2414	316	2	low	low	ADJ
admet-2414	316	3	concentration	concentration	NOUN
admet-2414	316	4	range	range	NOUN
admet-2414	316	5	is	be	AUX
admet-2414	316	6	physiologically	physiologically	ADV
admet-2414	316	7	important	important	ADJ
admet-2414	316	8	for	for	ADP
admet-2414	316	9	estimates	estimate	NOUN
admet-2414	316	10	of	of	ADP
admet-2414	316	11	the	the	DET
admet-2414	316	12	transcriptional	transcriptional	ADJ
admet-2414	316	13	activity	activity	NOUN
admet-2414	316	14	of	of	ADP
admet-2414	316	15	human	human	ADJ
admet-2414	316	16	endogenous	endogenous	ADJ
admet-2414	316	17	cortisol	cortisol	NOUN
admet-2414	316	18	.	.	PUNCT
admet-2414	317	1	as	as	SCONJ
admet-2414	317	2	shown	show	VERB
admet-2414	317	3	in	in	ADP
admet-2414	317	4	figure	figure	NOUN
admet-2414	317	5	8	8	NUM
admet-2414	317	6	,	,	PUNCT
admet-2414	317	7	at	at	ADP
admet-2414	317	8	the	the	DET
admet-2414	317	9	nadir	nadir	NOUN
admet-2414	317	10	cortisol	cortisol	NOUN
admet-2414	317	11	concentration	concentration	NOUN
admet-2414	317	12	,	,	PUNCT
admet-2414	317	13	the	the	DET
admet-2414	317	14	model	model	NOUN
admet-2414	317	15	predicted	predict	VERB
admet-2414	317	16	transcriptional	transcriptional	ADJ
admet-2414	317	17	activity	activity	NOUN
admet-2414	317	18	is	be	AUX
admet-2414	317	19	2.7	2.7	NUM
admet-2414	317	20	times	time	NOUN
admet-2414	317	21	greater	great	ADJ
admet-2414	317	22	than	than	ADP
admet-2414	317	23	what	what	PRON
admet-2414	317	24	would	would	AUX
admet-2414	317	25	be	be	AUX
admet-2414	317	26	predicted	predict	VERB
admet-2414	317	27	by	by	ADP
admet-2414	317	28	extrapolation	extrapolation	NOUN
admet-2414	317	29	of	of	ADP
admet-2414	317	30	the	the	DET
admet-2414	317	31	experimental	experimental	ADJ
admet-2414	317	32	high	high	ADJ
admet-2414	317	33	concentration	concentration	NOUN
admet-2414	317	34	michaelis	michaeli	NOUN
admet-2414	317	35	-	-	PUNCT
admet-2414	317	36	menten	menten	ADJ
admet-2414	317	37	relation	relation	NOUN
admet-2414	317	38	(	(	PUNCT
admet-2414	317	39	blue	blue	ADJ
admet-2414	317	40	line	line	NOUN
admet-2414	317	41	)	)	PUNCT
admet-2414	317	42	.	.	PUNCT
admet-2414	318	1	this	this	DET
admet-2414	318	2	low	low	ADJ
admet-2414	318	3	concentration	concentration	NOUN
admet-2414	318	4	range	range	NOUN
admet-2414	318	5	is	be	AUX
admet-2414	318	6	also	also	ADV
admet-2414	318	7	important	important	ADJ
admet-2414	318	8	for	for	ADP
admet-2414	318	9	estimates	estimate	NOUN
admet-2414	318	10	of	of	ADP
admet-2414	318	11	the	the	DET
admet-2414	318	12	transcriptional	transcriptional	ADJ
admet-2414	318	13	activities	activity	NOUN
admet-2414	318	14	of	of	ADP
admet-2414	318	15	low	low	ADJ
admet-2414	318	16	concentrations	concentration	NOUN
admet-2414	318	17	of	of	ADP
admet-2414	318	18	methylprednisolone	methylprednisolone	NOUN
admet-2414	318	19	or	or	CCONJ
admet-2414	318	20	prednisone	prednisone	NOUN
admet-2414	318	21	where	where	SCONJ
admet-2414	318	22	,	,	PUNCT
admet-2414	318	23	as	as	SCONJ
admet-2414	318	24	can	can	AUX
admet-2414	318	25	be	be	AUX
admet-2414	318	26	seen	see	VERB
admet-2414	318	27	in	in	ADP
admet-2414	318	28	figs	fig	NOUN
admet-2414	318	29	.	.	PUNCT
admet-2414	319	1	10	10	NUM
admet-2414	319	2	and	and	CCONJ
admet-2414	319	3	11	11	NUM
admet-2414	319	4	,	,	PUNCT
admet-2414	319	5	the	the	DET
admet-2414	319	6	activity	activity	NOUN
admet-2414	319	7	does	do	AUX
admet-2414	319	8	not	not	PART
admet-2414	319	9	fall	fall	VERB
admet-2414	319	10	to	to	ADP
admet-2414	319	11	zero	zero	NUM
admet-2414	319	12	at	at	ADP
admet-2414	319	13	long	long	ADJ
admet-2414	319	14	times	time	NOUN
admet-2414	319	15	but	but	CCONJ
admet-2414	319	16	,	,	PUNCT
admet-2414	319	17	instead	instead	ADV
admet-2414	319	18	,	,	PUNCT
admet-2414	319	19	levels	level	NOUN
admet-2414	319	20	off	off	ADP
admet-2414	319	21	at	at	ADP
admet-2414	319	22	about	about	ADV
admet-2414	319	23	0.04	0.04	NUM
admet-2414	319	24	(	(	PUNCT
admet-2414	319	25	4	4	NUM
admet-2414	319	26	%	%	NOUN
admet-2414	319	27	of	of	ADP
admet-2414	319	28	the	the	DET
admet-2414	319	29	maximum	maximum	ADJ
admet-2414	319	30	activity	activity	NOUN
admet-2414	319	31	)	)	PUNCT
admet-2414	319	32	because	because	SCONJ
admet-2414	319	33	of	of	ADP
admet-2414	319	34	this	this	DET
admet-2414	319	35	high	high	ADJ
admet-2414	319	36	affinity	affinity	NOUN
admet-2414	319	37	.	.	PUNCT
admet-2414	320	1	there	there	PRON
admet-2414	320	2	are	be	VERB
admet-2414	320	3	,	,	PUNCT
admet-2414	320	4	at	at	ADP
admet-2414	320	5	least	least	ADJ
admet-2414	320	6	,	,	PUNCT
admet-2414	320	7	two	two	NUM
admet-2414	320	8	rather	rather	ADV
admet-2414	320	9	simple	simple	ADJ
admet-2414	320	10	experiments	experiment	NOUN
admet-2414	320	11	suggested	suggest	VERB
admet-2414	320	12	by	by	ADP
admet-2414	320	13	this	this	DET
admet-2414	320	14	analysis	analysis	NOUN
admet-2414	320	15	that	that	PRON
admet-2414	320	16	could	could	AUX
admet-2414	320	17	confirm	confirm	VERB
admet-2414	320	18	(	(	PUNCT
admet-2414	320	19	or	or	CCONJ
admet-2414	320	20	refute	refute	VERB
admet-2414	320	21	)	)	PUNCT
admet-2414	320	22	the	the	DET
admet-2414	320	23	model	model	NOUN
admet-2414	320	24	predictions	prediction	NOUN
admet-2414	320	25	.	.	PUNCT
admet-2414	321	1	the	the	DET
admet-2414	321	2	first	first	ADJ
admet-2414	321	3	is	be	AUX
admet-2414	321	4	a	a	DET
admet-2414	321	5	test	test	NOUN
admet-2414	321	6	of	of	ADP
admet-2414	321	7	the	the	DET
admet-2414	321	8	prediction	prediction	NOUN
admet-2414	321	9	of	of	ADP
admet-2414	321	10	the	the	DET
admet-2414	321	11	very	very	ADV
admet-2414	321	12	high	high	ADJ
admet-2414	321	13	affinity	affinity	NOUN
admet-2414	321	14	of	of	ADP
admet-2414	321	15	gr	gr	NUM
admet-2414	321	16	at	at	ADP
admet-2414	321	17	very	very	ADV
admet-2414	321	18	low	low	ADJ
admet-2414	321	19	g	g	NOUN
admet-2414	321	20	concentration	concentration	NOUN
admet-2414	321	21	.	.	PUNCT
admet-2414	322	1	these	these	DET
admet-2414	322	2	studies	study	NOUN
admet-2414	322	3	would	would	AUX
admet-2414	322	4	have	have	VERB
admet-2414	322	5	to	to	PART
admet-2414	322	6	be	be	AUX
admet-2414	322	7	able	able	ADJ
admet-2414	322	8	to	to	PART
admet-2414	322	9	detect	detect	VERB
admet-2414	322	10	a	a	DET
admet-2414	322	11	residual	residual	ADJ
admet-2414	322	12	activity	activity	NOUN
admet-2414	322	13	of	of	ADP
admet-2414	322	14	about	about	ADV
admet-2414	322	15	4	4	NUM
admet-2414	322	16	%	%	NOUN
admet-2414	322	17	of	of	ADP
admet-2414	322	18	the	the	DET
admet-2414	322	19	maximum	maximum	NOUN
admet-2414	322	20	at	at	ADP
admet-2414	322	21	,	,	PUNCT
admet-2414	322	22	e.g.	e.g.	ADV
admet-2414	322	23	,	,	PUNCT
admet-2414	322	24	a	a	DET
admet-2414	322	25	dex	dex	NOUN
admet-2414	322	26	concentration	concentration	NOUN
admet-2414	322	27	of	of	ADP
admet-2414	322	28	0.01	0.01	NUM
admet-2414	322	29	nm	nm	NOUN
admet-2414	322	30	or	or	CCONJ
admet-2414	322	31	less	less	ADJ
admet-2414	322	32	.	.	PUNCT
admet-2414	323	1	the	the	DET
admet-2414	323	2	second	second	NOUN
admet-2414	323	3	is	be	AUX
admet-2414	323	4	a	a	DET
admet-2414	323	5	test	test	NOUN
admet-2414	323	6	of	of	ADP
admet-2414	323	7	the	the	DET
admet-2414	323	8	model	model	NOUN
admet-2414	323	9	prediction	prediction	NOUN
admet-2414	323	10	of	of	ADP
admet-2414	323	11	the	the	DET
admet-2414	323	12	dependence	dependence	NOUN
admet-2414	323	13	of	of	ADP
admet-2414	323	14	the	the	DET
admet-2414	323	15	high	high	ADJ
admet-2414	323	16	concentration	concentration	NOUN
admet-2414	323	17	kmh	kmh	NOUN
admet-2414	323	18	(=	(=	X
admet-2414	323	19	kmt	kmt	PROPN
admet-2414	323	20	)	)	PUNCT
admet-2414	323	21	on	on	ADP
admet-2414	323	22	the	the	DET
admet-2414	323	23	model	model	NOUN
admet-2414	323	24	parameters	parameter	NOUN
admet-2414	323	25	kn	kn	PROPN
admet-2414	323	26	,	,	PUNCT
admet-2414	323	27	k3	k3	PROPN
admet-2414	323	28	,	,	PUNCT
admet-2414	323	29	k4	k4	NOUN
admet-2414	323	30	and	and	CCONJ
admet-2414	323	31	k6	k6	NOUN
admet-2414	323	32	(	(	PUNCT
admet-2414	323	33	equation	equation	NOUN
admet-2414	323	34	(	(	PUNCT
admet-2414	323	35	3	3	NUM
admet-2414	323	36	)	)	PUNCT
admet-2414	323	37	)	)	PUNCT
admet-2414	323	38	,	,	PUNCT
admet-2414	323	39	specifically	specifically	ADV
admet-2414	323	40	,	,	PUNCT
admet-2414	323	41	the	the	DET
admet-2414	323	42	intrinsic	intrinsic	ADJ
admet-2414	323	43	kn	kn	NOUN
admet-2414	323	44	of	of	ADP
admet-2414	323	45	the	the	DET
admet-2414	323	46	unbound	unbound	NOUN
admet-2414	323	47	nuclear	nuclear	ADJ
admet-2414	323	48	receptor	receptor	NOUN
admet-2414	323	49	should	should	AUX
admet-2414	323	50	be	be	AUX
admet-2414	323	51	about	about	ADV
admet-2414	323	52	30	30	NUM
admet-2414	323	53	times	time	NOUN
admet-2414	323	54	greater	great	ADJ
admet-2414	323	55	than	than	ADP
admet-2414	323	56	the	the	DET
admet-2414	323	57	experimentally	experimentally	ADV
admet-2414	323	58	measured	measure	VERB
admet-2414	323	59	kmt	kmt	PROPN
admet-2414	323	60	,	,	PUNCT
admet-2414	323	61	(	(	PUNCT
admet-2414	323	62	table	table	NOUN
admet-2414	323	63	3	3	NUM
admet-2414	323	64	)	)	PUNCT
admet-2414	323	65	.	.	PUNCT
admet-2414	324	1	it	it	PRON
admet-2414	324	2	should	should	AUX
admet-2414	324	3	be	be	AUX
admet-2414	324	4	possible	possible	ADJ
admet-2414	324	5	to	to	PART
admet-2414	324	6	directly	directly	ADV
admet-2414	324	7	measure	measure	VERB
admet-2414	324	8	kn	kn	PROPN
admet-2414	324	9	by	by	ADP
admet-2414	324	10	,	,	PUNCT
admet-2414	324	11	first	first	ADV
admet-2414	324	12	,	,	PUNCT
admet-2414	324	13	incubating	incubate	VERB
admet-2414	324	14	cells	cell	NOUN
admet-2414	324	15	at	at	ADP
admet-2414	324	16	37	37	NUM
admet-2414	324	17	°	°	SYM
admet-2414	324	18	c	c	PROPN
admet-2414	324	19	in	in	ADP
admet-2414	324	20	dex	dex	NOUN
admet-2414	324	21	for	for	ADP
admet-2414	324	22	30	30	NUM
admet-2414	324	23	minutes	minute	NOUN
admet-2414	324	24	,	,	PUNCT
admet-2414	324	25	so	so	SCONJ
admet-2414	324	26	that	that	SCONJ
admet-2414	324	27	all	all	DET
admet-2414	324	28	receptor	receptor	NOUN
admet-2414	324	29	is	be	AUX
admet-2414	324	30	nuclear	nuclear	ADJ
admet-2414	324	31	,	,	PUNCT
admet-2414	324	32	then	then	ADV
admet-2414	324	33	,	,	PUNCT
admet-2414	324	34	switching	switch	VERB
admet-2414	324	35	to	to	ADP
admet-2414	324	36	a	a	DET
admet-2414	324	37	dex	dex	NOUN
admet-2414	324	38	free	free	ADJ
admet-2414	324	39	medium	medium	NOUN
admet-2414	324	40	for	for	ADP
admet-2414	324	41	about	about	ADV
admet-2414	324	42	30	30	NUM
admet-2414	324	43	minutes	minute	NOUN
admet-2414	324	44	,	,	PUNCT
admet-2414	324	45	so	so	SCONJ
admet-2414	324	46	that	that	SCONJ
admet-2414	324	47	the	the	DET
admet-2414	324	48	nuclear	nuclear	ADJ
admet-2414	324	49	receptor	receptor	NOUN
admet-2414	324	50	goes	go	VERB
admet-2414	324	51	into	into	ADP
admet-2414	324	52	the	the	DET
admet-2414	324	53	unbound	unbound	PROPN
admet-2414	324	54	rn	rn	PROPN
admet-2414	324	55	state	state	PROPN
admet-2414	324	56	(	(	PUNCT
admet-2414	324	57	but	but	CCONJ
admet-2414	324	58	still	still	ADV
admet-2414	324	59	is	be	AUX
admet-2414	324	60	nearly	nearly	ADV
admet-2414	324	61	all	all	PRON
admet-2414	324	62	nuclear	nuclear	ADJ
admet-2414	324	63	)	)	PUNCT
admet-2414	324	64	and	and	CCONJ
admet-2414	324	65	then	then	ADV
admet-2414	324	66	,	,	PUNCT
admet-2414	324	67	at	at	ADP
admet-2414	324	68	0	0	NUM
admet-2414	324	69	°	°	ADP
admet-2414	324	70	c	c	NOUN
admet-2414	324	71	,	,	PUNCT
admet-2414	324	72	measure	measure	VERB
admet-2414	324	73	the	the	DET
admet-2414	324	74	receptor	receptor	NOUN
admet-2414	324	75	binding	bind	VERB
admet-2414	324	76	constant	constant	ADJ
admet-2414	324	77	kn	kn	NOUN
admet-2414	324	78	in	in	ADP
admet-2414	324	79	lysed	lysed	ADJ
admet-2414	324	80	cells	cell	NOUN
admet-2414	324	81	.	.	PUNCT
admet-2414	325	1	most	most	ADJ
admet-2414	325	2	of	of	ADP
admet-2414	325	3	the	the	DET
admet-2414	325	4	gr	gr	PROPN
admet-2414	325	5	mechanistic	mechanistic	ADJ
admet-2414	325	6	studies	study	NOUN
admet-2414	325	7	have	have	AUX
admet-2414	325	8	used	use	VERB
admet-2414	325	9	dex	dex	NOUN
admet-2414	325	10	as	as	ADP
admet-2414	325	11	the	the	DET
admet-2414	325	12	test	test	NOUN
admet-2414	325	13	glucuronide	glucuronide	NOUN
admet-2414	325	14	and	and	CCONJ
admet-2414	325	15	the	the	DET
admet-2414	325	16	rate	rate	NOUN
admet-2414	325	17	constants	constant	NOUN
admet-2414	325	18	k1	k1	NOUN
admet-2414	325	19	–	–	PUNCT
admet-2414	325	20	k6	k6	NOUN
admet-2414	325	21	listed	list	VERB
admet-2414	325	22	in	in	ADP
admet-2414	325	23	table	table	NOUN
admet-2414	325	24	1	1	NUM
admet-2414	325	25	are	be	AUX
admet-2414	325	26	based	base	VERB
admet-2414	325	27	on	on	ADP
admet-2414	325	28	these	these	DET
admet-2414	325	29	studies	study	NOUN
admet-2414	325	30	.	.	PUNCT
admet-2414	326	1	in	in	ADP
admet-2414	326	2	applying	apply	VERB
admet-2414	326	3	the	the	DET
admet-2414	326	4	model	model	NOUN
admet-2414	326	5	to	to	ADP
admet-2414	326	6	the	the	DET
admet-2414	326	7	lower	low	ADJ
admet-2414	326	8	affinity	affinity	NOUN
admet-2414	326	9	cortisol	cortisol	NOUN
admet-2414	326	10	,	,	PUNCT
admet-2414	326	11	methylprednisolone	methylprednisolone	PROPN
admet-2414	326	12	and	and	CCONJ
admet-2414	326	13	prednisone	prednisone	NOUN
admet-2414	326	14	,	,	PUNCT
admet-2414	326	15	it	it	PRON
admet-2414	326	16	was	be	AUX
admet-2414	326	17	assumed	assume	VERB
admet-2414	326	18	that	that	SCONJ
admet-2414	326	19	only	only	ADV
admet-2414	326	20	the	the	DET
admet-2414	326	21	equilibrium	equilibrium	NOUN
admet-2414	326	22	binding	bind	VERB
admet-2414	326	23	constants	constant	NOUN
admet-2414	326	24	kc	kc	PROPN
admet-2414	326	25	and	and	CCONJ
admet-2414	326	26	kn	kn	PROPN
admet-2414	326	27	depend	depend	VERB
admet-2414	326	28	on	on	ADP
admet-2414	326	29	g	g	NOUN
admet-2414	326	30	,	,	PUNCT
admet-2414	326	31	while	while	SCONJ
admet-2414	326	32	the	the	DET
admet-2414	326	33	rate	rate	NOUN
admet-2414	326	34	constants	constant	NOUN
admet-2414	326	35	k1	k1	NOUN
admet-2414	326	36	–	–	PUNCT
admet-2414	326	37	k6	k6	NOUN
admet-2414	326	38	are	be	AUX
admet-2414	326	39	g	g	NOUN
admet-2414	326	40	independent	independent	ADJ
admet-2414	326	41	.	.	PUNCT
admet-2414	327	1	this	this	PRON
admet-2414	327	2	might	might	AUX
admet-2414	327	3	be	be	AUX
admet-2414	327	4	expected	expect	VERB
admet-2414	327	5	because	because	SCONJ
admet-2414	327	6	,	,	PUNCT
admet-2414	327	7	in	in	ADP
admet-2414	327	8	the	the	DET
admet-2414	327	9	tightly	tightly	ADV
admet-2414	327	10	bound	bind	VERB
admet-2414	327	11	states	state	NOUN
admet-2414	327	12	,	,	PUNCT
admet-2414	327	13	the	the	DET
admet-2414	327	14	g	g	NOUN
admet-2414	327	15	is	be	AUX
admet-2414	327	16	buried	bury	VERB
admet-2414	327	17	deep	deep	ADV
admet-2414	327	18	inside	inside	ADP
admet-2414	327	19	the	the	DET
admet-2414	327	20	protein	protein	NOUN
admet-2414	327	21	so	so	SCONJ
admet-2414	327	22	that	that	SCONJ
admet-2414	327	23	the	the	DET
admet-2414	327	24	protein	protein	NOUN
admet-2414	327	25	surface	surface	NOUN
admet-2414	327	26	with	with	ADP
admet-2414	327	27	its	its	PRON
admet-2414	327	28	chaperone	chaperone	NOUN
admet-2414	327	29	and	and	CCONJ
admet-2414	327	30	auxiliary	auxiliary	ADJ
admet-2414	327	31	binding	bind	VERB
admet-2414	327	32	sites	site	NOUN
admet-2414	327	33	should	should	AUX
admet-2414	327	34	not	not	PART
admet-2414	327	35	depend	depend	VERB
admet-2414	327	36	on	on	ADP
admet-2414	327	37	g.	g.	PROPN
admet-2414	327	38	however	however	ADV
admet-2414	327	39	,	,	PUNCT
admet-2414	327	40	schaaf	schaaf	PROPN
admet-2414	327	41	et	et	PROPN
admet-2414	327	42	.	.	PUNCT
admet-2414	328	1	al	al	PROPN
admet-2414	328	2	.	.	PUNCT
admet-2414	329	1	[	[	X
admet-2414	329	2	49	49	NUM
admet-2414	329	3	]	]	PUNCT
admet-2414	329	4	have	have	AUX
admet-2414	329	5	reported	report	VERB
admet-2414	329	6	that	that	SCONJ
admet-2414	329	7	the	the	DET
admet-2414	329	8	pattern	pattern	NOUN
admet-2414	329	9	of	of	ADP
admet-2414	329	10	nuclear	nuclear	ADJ
admet-2414	329	11	binding	binding	NOUN
admet-2414	329	12	of	of	ADP
admet-2414	329	13	gr	gr	ADJ
admet-2414	329	14	-	-	PUNCT
admet-2414	329	15	yellow	yellow	ADJ
admet-2414	329	16	fluorescent	fluorescent	NOUN
admet-2414	329	17	protein	protein	NOUN
admet-2414	329	18	is	be	AUX
admet-2414	329	19	definitely	definitely	ADV
admet-2414	329	20	g	g	NOUN
admet-2414	329	21	dependent	dependent	ADJ
admet-2414	329	22	,	,	PUNCT
admet-2414	329	23	suggesting	suggest	VERB
admet-2414	329	24	that	that	SCONJ
admet-2414	329	25	some	some	PRON
admet-2414	329	26	of	of	ADP
admet-2414	329	27	the	the	DET
admet-2414	329	28	rate	rate	NOUN
admet-2414	329	29	constants	constant	NOUN
admet-2414	329	30	might	might	AUX
admet-2414	329	31	also	also	ADV
admet-2414	329	32	be	be	AUX
admet-2414	329	33	g	g	NOUN
admet-2414	329	34	dependent	dependent	ADJ
admet-2414	329	35	.	.	PUNCT
admet-2414	330	1	glucocorticoids	glucocorticoid	NOUN
admet-2414	330	2	are	be	AUX
admet-2414	330	3	used	use	VERB
admet-2414	330	4	clinically	clinically	ADV
admet-2414	330	5	over	over	ADP
admet-2414	330	6	a	a	DET
admet-2414	330	7	huge	huge	ADJ
admet-2414	330	8	dosage	dosage	NOUN
admet-2414	330	9	range	range	NOUN
admet-2414	330	10	.	.	PUNCT
admet-2414	331	1	the	the	DET
admet-2414	331	2	rational	rational	ADJ
admet-2414	331	3	for	for	ADP
admet-2414	331	4	these	these	DET
admet-2414	331	5	dosages	dosage	NOUN
admet-2414	331	6	,	,	PUNCT
admet-2414	331	7	especially	especially	ADV
admet-2414	331	8	in	in	ADP
admet-2414	331	9	the	the	DET
admet-2414	331	10	higher	high	ADJ
admet-2414	331	11	dosage	dosage	NOUN
admet-2414	331	12	range	range	NOUN
admet-2414	331	13	,	,	PUNCT
admet-2414	331	14	is	be	AUX
admet-2414	331	15	based	base	VERB
admet-2414	331	16	primarily	primarily	ADV
admet-2414	331	17	on	on	ADP
admet-2414	331	18	traditional	traditional	ADJ
admet-2414	331	19	regimens	regimen	NOUN
admet-2414	331	20	dating	date	VERB
admet-2414	331	21	back	back	ADV
admet-2414	331	22	50	50	NUM
admet-2414	331	23	years	year	NOUN
admet-2414	331	24	or	or	CCONJ
admet-2414	331	25	more	more	ADJ
admet-2414	331	26	[	[	X
admet-2414	331	27	14	14	NUM
admet-2414	331	28	]	]	PUNCT
admet-2414	331	29	.	.	PUNCT
admet-2414	332	1	this	this	DET
admet-2414	332	2	lack	lack	NOUN
admet-2414	332	3	of	of	ADP
admet-2414	332	4	a	a	DET
admet-2414	332	5	rigorous	rigorous	ADJ
admet-2414	332	6	pharmacological	pharmacological	NOUN
admet-2414	332	7	foundation	foundation	NOUN
admet-2414	332	8	is	be	AUX
admet-2414	332	9	in	in	ADP
admet-2414	332	10	part	part	NOUN
admet-2414	332	11	explained	explain	VERB
admet-2414	332	12	by	by	ADP
admet-2414	332	13	the	the	DET
admet-2414	332	14	complicated	complicated	ADJ
admet-2414	332	15	pharmacodynamic	pharmacodynamic	ADJ
admet-2414	332	16	(	(	PUNCT
admet-2414	332	17	pd	pd	NOUN
admet-2414	332	18	)	)	PUNCT
admet-2414	332	19	dose	dose	NOUN
admet-2414	332	20	-	-	PUNCT
admet-2414	332	21	response	response	NOUN
admet-2414	332	22	relationships	relationship	NOUN
admet-2414	332	23	of	of	ADP
admet-2414	332	24	glucocorticoids	glucocorticoid	NOUN
admet-2414	332	25	[	[	X
admet-2414	332	26	50	50	NUM
admet-2414	332	27	]	]	PUNCT
admet-2414	332	28	.	.	PUNCT
admet-2414	333	1	not	not	PART
admet-2414	333	2	only	only	ADV
admet-2414	333	3	is	be	AUX
admet-2414	333	4	the	the	DET
admet-2414	333	5	gr	gr	NOUN
admet-2414	333	6	involved	involve	VERB
admet-2414	333	7	in	in	ADP
admet-2414	333	8	the	the	DET
admet-2414	333	9	complex	complex	ADJ
admet-2414	333	10	dynamics	dynamic	NOUN
admet-2414	333	11	discussed	discuss	VERB
admet-2414	333	12	here	here	ADV
admet-2414	333	13	(	(	PUNCT
admet-2414	333	14	figure	figure	NOUN
admet-2414	333	15	1	1	NUM
admet-2414	333	16	)	)	PUNCT
admet-2414	333	17	,	,	PUNCT
admet-2414	333	18	but	but	CCONJ
admet-2414	333	19	,	,	PUNCT
admet-2414	333	20	since	since	SCONJ
admet-2414	333	21	the	the	DET
admet-2414	333	22	result	result	NOUN
admet-2414	333	23	of	of	ADP
admet-2414	333	24	the	the	DET
admet-2414	333	25	dna	dna	PROPN
admet-2414	333	26	transcriptional	transcriptional	NOUN
admet-2414	333	27	modification	modification	NOUN
admet-2414	333	28	may	may	AUX
admet-2414	333	29	take	take	VERB
admet-2414	333	30	6	6	NUM
admet-2414	333	31	hours	hour	NOUN
admet-2414	333	32	or	or	CCONJ
admet-2414	333	33	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	333	34	d.	d.	PROPN
admet-2414	333	35	g.	g.	PROPN
admet-2414	333	36	levitt	levitt	PROPN
admet-2414	333	37	admet	admet	PROPN
admet-2414	333	38	&	&	CCONJ
admet-2414	333	39	dmpk	dmpk	PROPN
admet-2414	333	40	12(6	12(6	NUM
admet-2414	333	41	)	)	PUNCT
admet-2414	333	42	(	(	PUNCT
admet-2414	333	43	2024	2024	NUM
admet-2414	333	44	)	)	PUNCT
admet-2414	333	45	971	971	NUM
admet-2414	333	46	-	-	SYM
admet-2414	333	47	989	989	NUM
admet-2414	333	48	986	986	NUM
admet-2414	333	49	more	more	ADJ
admet-2414	333	50	to	to	PART
admet-2414	333	51	reach	reach	VERB
admet-2414	333	52	maximum	maximum	ADJ
admet-2414	333	53	effect	effect	NOUN
admet-2414	333	54	and	and	CCONJ
admet-2414	333	55	may	may	AUX
admet-2414	333	56	last	last	VERB
admet-2414	333	57	for	for	ADP
admet-2414	333	58	many	many	ADJ
admet-2414	333	59	days	day	NOUN
admet-2414	333	60	,	,	PUNCT
admet-2414	333	61	it	it	PRON
admet-2414	333	62	is	be	AUX
admet-2414	333	63	difficult	difficult	ADJ
admet-2414	333	64	to	to	PART
admet-2414	333	65	quantify	quantify	VERB
admet-2414	333	66	the	the	DET
admet-2414	333	67	dose	dose	NOUN
admet-2414	333	68	-	-	PUNCT
admet-2414	333	69	response	response	NOUN
admet-2414	333	70	.	.	PUNCT
admet-2414	334	1	the	the	DET
admet-2414	334	2	gtq	gtq	PROPN
admet-2414	334	3	(	(	PUNCT
admet-2414	334	4	equation	equation	NOUN
admet-2414	334	5	(	(	PUNCT
admet-2414	334	6	6	6	NUM
admet-2414	334	7	)	)	PUNCT
admet-2414	334	8	)	)	PUNCT
admet-2414	334	9	is	be	AUX
admet-2414	334	10	introduced	introduce	VERB
admet-2414	334	11	here	here	ADV
admet-2414	334	12	as	as	ADP
admet-2414	334	13	an	an	DET
admet-2414	334	14	approximate	approximate	ADJ
admet-2414	334	15	cell	cell	NOUN
admet-2414	334	16	culture	culture	NOUN
admet-2414	334	17	based	base	VERB
admet-2414	334	18	approach	approach	NOUN
admet-2414	334	19	to	to	ADP
admet-2414	334	20	quantifying	quantify	VERB
admet-2414	334	21	the	the	DET
admet-2414	334	22	pd	pd	PROPN
admet-2414	334	23	.	.	PUNCT
admet-2414	335	1	it	it	PRON
admet-2414	335	2	assumes	assume	VERB
admet-2414	335	3	that	that	SCONJ
admet-2414	335	4	the	the	DET
admet-2414	335	5	g	g	PROPN
admet-2414	335	6	activity	activity	NOUN
admet-2414	335	7	is	be	AUX
admet-2414	335	8	determined	determine	VERB
admet-2414	335	9	by	by	ADP
admet-2414	335	10	the	the	DET
admet-2414	335	11	daily	daily	ADJ
admet-2414	335	12	average	average	NOUN
admet-2414	335	13	of	of	ADP
admet-2414	335	14	the	the	DET
admet-2414	335	15	fraction	fraction	NOUN
admet-2414	335	16	of	of	ADP
admet-2414	335	17	the	the	DET
admet-2414	335	18	gr	gr	NOUN
admet-2414	335	19	that	that	PRON
admet-2414	335	20	is	be	AUX
admet-2414	335	21	in	in	ADP
admet-2414	335	22	the	the	DET
admet-2414	335	23	conformation	conformation	NOUN
admet-2414	335	24	that	that	PRON
admet-2414	335	25	can	can	AUX
admet-2414	335	26	potentially	potentially	ADV
admet-2414	335	27	bind	bind	VERB
admet-2414	335	28	to	to	ADP
admet-2414	335	29	and	and	CCONJ
admet-2414	335	30	modify	modify	VERB
admet-2414	335	31	dna	dna	PROPN
admet-2414	335	32	.	.	PUNCT
admet-2414	336	1	the	the	DET
admet-2414	336	2	gtq	gtq	NOUN
admet-2414	336	3	for	for	ADP
admet-2414	336	4	endogenous	endogenous	ADJ
admet-2414	336	5	cortisol	cortisol	NOUN
admet-2414	336	6	and	and	CCONJ
admet-2414	336	7	varying	vary	VERB
admet-2414	336	8	doses	dose	NOUN
admet-2414	336	9	of	of	ADP
admet-2414	336	10	dex	dex	NOUN
admet-2414	336	11	,	,	PUNCT
admet-2414	336	12	mp	mp	PROPN
admet-2414	336	13	and	and	CCONJ
admet-2414	336	14	prednisone	prednisone	PROPN
admet-2414	336	15	are	be	AUX
admet-2414	336	16	summarized	summarize	VERB
admet-2414	336	17	in	in	ADP
admet-2414	336	18	table	table	NOUN
admet-2414	336	19	4	4	NUM
admet-2414	336	20	.	.	PUNCT
admet-2414	337	1	although	although	SCONJ
admet-2414	337	2	it	it	PRON
admet-2414	337	3	is	be	AUX
admet-2414	337	4	obviously	obviously	ADV
admet-2414	337	5	a	a	DET
admet-2414	337	6	great	great	ADJ
admet-2414	337	7	oversimplification	oversimplification	NOUN
admet-2414	337	8	,	,	PUNCT
admet-2414	337	9	neglecting	neglect	VERB
admet-2414	337	10	factors	factor	NOUN
admet-2414	337	11	such	such	ADJ
admet-2414	337	12	as	as	ADP
admet-2414	337	13	gr	gr	NUM
admet-2414	337	14	turnover	turnover	NOUN
admet-2414	337	15	and	and	CCONJ
admet-2414	337	16	downregulation	downregulation	NOUN
admet-2414	337	17	[	[	X
admet-2414	337	18	51,52	51,52	NUM
admet-2414	337	19	]	]	PUNCT
admet-2414	337	20	and	and	CCONJ
admet-2414	337	21	cytosolic	cytosolic	ADJ
admet-2414	337	22	gr	gr	NOUN
admet-2414	337	23	effects	effect	NOUN
admet-2414	337	24	[	[	X
admet-2414	337	25	15,16	15,16	NUM
admet-2414	337	26	]	]	PUNCT
admet-2414	337	27	,	,	PUNCT
admet-2414	337	28	it	it	PRON
admet-2414	337	29	is	be	AUX
admet-2414	337	30	hoped	hope	VERB
admet-2414	337	31	that	that	SCONJ
admet-2414	337	32	the	the	DET
admet-2414	337	33	it	it	PRON
admet-2414	337	34	may	may	AUX
admet-2414	337	35	provide	provide	VERB
admet-2414	337	36	a	a	DET
admet-2414	337	37	useful	useful	ADJ
admet-2414	337	38	approach	approach	NOUN
admet-2414	337	39	to	to	ADP
admet-2414	337	40	quantifying	quantify	VERB
admet-2414	337	41	the	the	DET
admet-2414	337	42	pd	pd	NOUN
admet-2414	337	43	of	of	ADP
admet-2414	337	44	glucocorticoids	glucocorticoids	PROPN
admet-2414	337	45	.	.	PUNCT
admet-2414	338	1	supplementary	supplementary	ADJ
admet-2414	338	2	material	material	NOUN
admet-2414	338	3	additional	additional	ADJ
admet-2414	338	4	data	datum	NOUN
admet-2414	338	5	are	be	AUX
admet-2414	338	6	available	available	ADJ
admet-2414	338	7	at	at	ADP
admet-2414	338	8	https://pub.iapchem.org/ojs/index.php/admet/article/view/2414	https://pub.iapchem.org/ojs/index.php/admet/article/view/2414	NOUN
admet-2414	338	9	,	,	PUNCT
admet-2414	338	10	or	or	CCONJ
admet-2414	338	11	from	from	ADP
admet-2414	338	12	the	the	DET
admet-2414	338	13	corresponding	corresponding	ADJ
admet-2414	338	14	author	author	NOUN
admet-2414	338	15	on	on	ADP
admet-2414	338	16	request	request	NOUN
admet-2414	338	17	.	.	PUNCT
admet-2414	339	1	acknowledgments	acknowledgment	NOUN
admet-2414	339	2	:	:	PUNCT
admet-2414	340	1	none	none	NOUN
admet-2414	340	2	funding	funding	NOUN
admet-2414	340	3	:	:	PUNCT
admet-2414	340	4	none	none	NOUN
admet-2414	340	5	conflicts	conflict	NOUN
admet-2414	340	6	of	of	ADP
admet-2414	340	7	interest	interest	NOUN
admet-2414	340	8	:	:	PUNCT
admet-2414	340	9	the	the	DET
admet-2414	340	10	author	author	NOUN
admet-2414	340	11	certifies	certify	VERB
admet-2414	340	12	that	that	SCONJ
admet-2414	340	13	he	he	PRON
admet-2414	340	14	has	have	VERB
admet-2414	340	15	no	no	DET
admet-2414	340	16	financial	financial	ADJ
admet-2414	340	17	or	or	CCONJ
admet-2414	340	18	other	other	ADJ
admet-2414	340	19	conflict	conflict	NOUN
admet-2414	340	20	of	of	ADP
admet-2414	340	21	interest	interest	NOUN
admet-2414	340	22	.	.	PUNCT
admet-2414	341	1	data	datum	NOUN
admet-2414	341	2	availability	availability	NOUN
admet-2414	341	3	:	:	PUNCT
admet-2414	341	4	all	all	DET
admet-2414	341	5	relevant	relevant	ADJ
admet-2414	341	6	data	datum	NOUN
admet-2414	341	7	are	be	AUX
admet-2414	341	8	contained	contain	VERB
admet-2414	341	9	in	in	ADP
admet-2414	341	10	either	either	CCONJ
admet-2414	341	11	the	the	DET
admet-2414	341	12	main	main	ADJ
admet-2414	341	13	manuscript	manuscript	NOUN
admet-2414	341	14	or	or	CCONJ
admet-2414	341	15	in	in	ADP
admet-2414	341	16	the	the	DET
admet-2414	341	17	supplementary	supplementary	ADJ
admet-2414	341	18	material	material	NOUN
admet-2414	341	19	.	.	PUNCT
admet-2414	342	1	references	reference	NOUN
admet-2414	342	2	[	[	X
admet-2414	342	3	1	1	NUM
admet-2414	342	4	]	]	PUNCT
admet-2414	342	5	a.	a.	NOUN
admet-2414	342	6	munck	munck	NOUN
admet-2414	342	7	,	,	PUNCT
admet-2414	342	8	t.	t.	PROPN
admet-2414	342	9	brinck	brinck	NOUN
admet-2414	342	10	-	-	PUNCT
admet-2414	342	11	johnsen	johnsen	PROPN
admet-2414	342	12	.	.	PUNCT
admet-2414	343	1	specific	specific	ADJ
admet-2414	343	2	and	and	CCONJ
admet-2414	343	3	nonspecific	nonspecific	ADJ
admet-2414	343	4	physicochemical	physicochemical	ADJ
admet-2414	343	5	interactions	interaction	NOUN
admet-2414	343	6	of	of	ADP
admet-2414	343	7	glucocorticoids	glucocorticoid	NOUN
admet-2414	343	8	and	and	CCONJ
admet-2414	343	9	related	relate	VERB
admet-2414	343	10	steroids	steroid	NOUN
admet-2414	343	11	with	with	ADP
admet-2414	343	12	rat	rat	NOUN
admet-2414	343	13	thymus	thymus	ADJ
admet-2414	343	14	cells	cell	NOUN
admet-2414	343	15	in	in	ADP
admet-2414	343	16	vitro	vitro	VERB
admet-2414	343	17	.	.	PUNCT
admet-2414	344	1	j	j	PROPN
admet-2414	344	2	biol	biol	PROPN
admet-2414	344	3	chem	chem	NOUN
admet-2414	344	4	243	243	NUM
admet-2414	344	5	(	(	PUNCT
admet-2414	344	6	1968	1968	NUM
admet-2414	344	7	)	)	PUNCT
admet-2414	344	8	55565565	55565565	NUM
admet-2414	344	9	.	.	PUNCT
admet-2414	345	1	https://www.ncbi.nlm.nih.gov/pubmed/5699052	https://www.ncbi.nlm.nih.gov/pubmed/5699052	X
admet-2414	345	2	.	.	PUNCT
admet-2414	346	1	[	[	X
admet-2414	346	2	2	2	NUM
admet-2414	346	3	]	]	PUNCT
admet-2414	346	4	a.	a.	NOUN
admet-2414	346	5	munck	munck	NOUN
admet-2414	346	6	.	.	PUNCT
admet-2414	347	1	glucocorticoid	glucocorticoid	ADJ
admet-2414	347	2	receptors	receptor	NOUN
admet-2414	347	3	and	and	CCONJ
admet-2414	347	4	physiology	physiology	NOUN
admet-2414	347	5	:	:	PUNCT
admet-2414	347	6	a	a	DET
admet-2414	347	7	personal	personal	ADJ
admet-2414	347	8	history	history	NOUN
admet-2414	347	9	.	.	PUNCT
admet-2414	348	1	steroids	steroid	NOUN
admet-2414	348	2	70	70	NUM
admet-2414	348	3	(	(	PUNCT
admet-2414	348	4	2005	2005	NUM
admet-2414	348	5	)	)	PUNCT
admet-2414	348	6	335	335	NUM
admet-2414	348	7	-	-	SYM
admet-2414	348	8	344	344	NUM
admet-2414	348	9	.	.	PUNCT
admet-2414	349	1	https://doi.org/10.1016/j.steroids.2004.12.002	https://doi.org/10.1016/j.steroids.2004.12.002	NOUN
admet-2414	349	2	.	.	PUNCT
admet-2414	350	1	[	[	X
admet-2414	350	2	3	3	NUM
admet-2414	350	3	]	]	PUNCT
admet-2414	350	4	a.	a.	NOUN
admet-2414	350	5	munck	munck	NOUN
admet-2414	350	6	,	,	PUNCT
admet-2414	350	7	c.	c.	PROPN
admet-2414	350	8	wira	wira	PROPN
admet-2414	350	9	,	,	PUNCT
admet-2414	350	10	d.a	d.a	PROPN
admet-2414	350	11	.	.	PROPN
admet-2414	350	12	young	young	PROPN
admet-2414	350	13	,	,	PUNCT
admet-2414	350	14	k.m	k.m	PROPN
admet-2414	350	15	.	.	PROPN
admet-2414	350	16	mosher	mosher	PROPN
admet-2414	350	17	,	,	PUNCT
admet-2414	350	18	c.	c.	PROPN
admet-2414	350	19	hallahan	hallahan	PROPN
admet-2414	350	20	,	,	PUNCT
admet-2414	350	21	p.a	p.a	PROPN
admet-2414	350	22	.	.	PROPN
admet-2414	350	23	bell	bell	PROPN
admet-2414	350	24	.	.	PUNCT
admet-2414	351	1	glucocorticoid	glucocorticoid	ADJ
admet-2414	351	2	-	-	PUNCT
admet-2414	351	3	receptor	receptor	NOUN
admet-2414	351	4	complexes	complex	NOUN
admet-2414	351	5	and	and	CCONJ
admet-2414	351	6	the	the	DET
admet-2414	351	7	earliest	early	ADJ
admet-2414	351	8	steps	step	NOUN
admet-2414	351	9	in	in	ADP
admet-2414	351	10	the	the	DET
admet-2414	351	11	action	action	NOUN
admet-2414	351	12	of	of	ADP
admet-2414	351	13	glucocorticoids	glucocorticoid	NOUN
admet-2414	351	14	on	on	ADP
admet-2414	351	15	thymus	thymus	ADJ
admet-2414	351	16	cells	cell	NOUN
admet-2414	351	17	.	.	PUNCT
admet-2414	352	1	j	j	PROPN
admet-2414	352	2	steroid	steroid	PROPN
admet-2414	352	3	biochem	biochem	PROPN
admet-2414	352	4	3	3	NUM
admet-2414	352	5	(	(	PUNCT
admet-2414	352	6	1972	1972	NUM
admet-2414	352	7	)	)	PUNCT
admet-2414	352	8	567	567	NUM
admet-2414	352	9	-	-	SYM
admet-2414	352	10	578	578	NUM
admet-2414	352	11	.	.	PUNCT
admet-2414	353	1	https://doi.org/10.1016/0022-4731(72)90103-3	https://doi.org/10.1016/0022-4731(72)90103-3	NOUN
admet-2414	353	2	.	.	PUNCT
admet-2414	354	1	[	[	X
admet-2414	354	2	4	4	X
admet-2414	354	3	]	]	PUNCT
admet-2414	354	4	e.	e.	PROPN
admet-2414	354	5	orti	orti	PROPN
admet-2414	354	6	,	,	PUNCT
admet-2414	354	7	d.b	d.b	PROPN
admet-2414	354	8	.	.	PROPN
admet-2414	354	9	mendel	mendel	PROPN
admet-2414	354	10	,	,	PUNCT
admet-2414	354	11	l.i	l.i	PROPN
admet-2414	354	12	.	.	PROPN
admet-2414	354	13	smith	smith	PROPN
admet-2414	354	14	,	,	PUNCT
admet-2414	354	15	j.e	j.e	PROPN
admet-2414	354	16	.	.	PROPN
admet-2414	354	17	bodwell	bodwell	PROPN
admet-2414	354	18	,	,	PUNCT
admet-2414	354	19	a.	a.	NOUN
admet-2414	354	20	munck	munck	NOUN
admet-2414	354	21	.	.	PUNCT
admet-2414	355	1	a	a	DET
admet-2414	355	2	dynamic	dynamic	ADJ
admet-2414	355	3	model	model	NOUN
admet-2414	355	4	of	of	ADP
admet-2414	355	5	glucocorticoid	glucocorticoid	ADJ
admet-2414	355	6	receptor	receptor	NOUN
admet-2414	355	7	phosphorylation	phosphorylation	NOUN
admet-2414	355	8	and	and	CCONJ
admet-2414	355	9	cycling	cycling	NOUN
admet-2414	355	10	in	in	ADP
admet-2414	355	11	intact	intact	ADJ
admet-2414	355	12	cells	cell	NOUN
admet-2414	355	13	.	.	PUNCT
admet-2414	356	1	j	j	PROPN
admet-2414	356	2	steroid	steroid	PROPN
admet-2414	356	3	biochem	biochem	PROPN
admet-2414	356	4	34	34	NUM
admet-2414	356	5	(	(	PUNCT
admet-2414	356	6	1989	1989	NUM
admet-2414	356	7	)	)	PUNCT
admet-2414	356	8	85	85	NUM
admet-2414	356	9	-	-	SYM
admet-2414	356	10	96	96	NUM
admet-2414	356	11	.	.	PUNCT
admet-2414	356	12	https://doi.org/10.1016/0022-4731(89)90069-1	https://doi.org/10.1016/0022-4731(89)90069-1	NOUN
admet-2414	356	13	.	.	PUNCT
admet-2414	357	1	[	[	X
admet-2414	357	2	5	5	X
admet-2414	357	3	]	]	X
admet-2414	357	4	r.k	r.k	PROPN
admet-2414	357	5	.	.	PROPN
admet-2414	357	6	bledsoe	bledsoe	PROPN
admet-2414	357	7	,	,	PUNCT
admet-2414	357	8	v.g	v.g	PROPN
admet-2414	357	9	.	.	PROPN
admet-2414	357	10	montana	montana	PROPN
admet-2414	357	11	,	,	PUNCT
admet-2414	357	12	t.b	t.b	PROPN
admet-2414	357	13	.	.	PROPN
admet-2414	357	14	stanley	stanley	PROPN
admet-2414	357	15	,	,	PUNCT
admet-2414	357	16	c.j	c.j	PROPN
admet-2414	357	17	.	.	PROPN
admet-2414	357	18	delves	delf	NOUN
admet-2414	357	19	,	,	PUNCT
admet-2414	357	20	c.j	c.j	PROPN
admet-2414	357	21	.	.	PROPN
admet-2414	357	22	apolito	apolito	PROPN
admet-2414	357	23	,	,	PUNCT
admet-2414	357	24	d.d	d.d	PROPN
admet-2414	357	25	.	.	PROPN
admet-2414	357	26	mckee	mckee	PROPN
admet-2414	357	27	,	,	PUNCT
admet-2414	357	28	t.g	t.g	PROPN
admet-2414	357	29	.	.	PROPN
admet-2414	357	30	consler	consler	NOUN
admet-2414	357	31	,	,	PUNCT
admet-2414	357	32	d.j	d.j	PROPN
admet-2414	357	33	.	.	PROPN
admet-2414	357	34	parks	parks	PROPN
admet-2414	357	35	,	,	PUNCT
admet-2414	357	36	e.l	e.l	PROPN
admet-2414	357	37	.	.	PROPN
admet-2414	357	38	stewart	stewart	PROPN
admet-2414	357	39	,	,	PUNCT
admet-2414	357	40	t.m	t.m	PROPN
admet-2414	357	41	.	.	PROPN
admet-2414	357	42	willson	willson	PROPN
admet-2414	357	43	,	,	PUNCT
admet-2414	357	44	m.h	m.h	PROPN
admet-2414	357	45	.	.	PROPN
admet-2414	357	46	lambert	lambert	PROPN
admet-2414	357	47	,	,	PUNCT
admet-2414	357	48	j.t	j.t	PROPN
admet-2414	357	49	.	.	PROPN
admet-2414	357	50	moore	moore	PROPN
admet-2414	357	51	,	,	PUNCT
admet-2414	357	52	k.h	k.h	PROPN
admet-2414	357	53	.	.	PROPN
admet-2414	357	54	pearce	pearce	PROPN
admet-2414	357	55	,	,	PUNCT
admet-2414	357	56	h.e	h.e	PROPN
admet-2414	357	57	.	.	PROPN
admet-2414	357	58	xu	xu	PROPN
admet-2414	357	59	.	.	PUNCT
admet-2414	358	1	crystal	crystal	NOUN
admet-2414	358	2	structure	structure	NOUN
admet-2414	358	3	of	of	ADP
admet-2414	358	4	the	the	DET
admet-2414	358	5	glucocorticoid	glucocorticoid	ADJ
admet-2414	358	6	receptor	receptor	NOUN
admet-2414	358	7	ligand	ligand	NOUN
admet-2414	358	8	binding	bind	VERB
admet-2414	358	9	domain	domain	NOUN
admet-2414	358	10	reveals	reveal	VERB
admet-2414	358	11	a	a	DET
admet-2414	358	12	novel	novel	ADJ
admet-2414	358	13	mode	mode	NOUN
admet-2414	358	14	of	of	ADP
admet-2414	358	15	receptor	receptor	NOUN
admet-2414	358	16	dimerization	dimerization	NOUN
admet-2414	358	17	and	and	CCONJ
admet-2414	358	18	coactivator	coactivator	NOUN
admet-2414	358	19	recognition	recognition	NOUN
admet-2414	358	20	.	.	PUNCT
admet-2414	359	1	cell	cell	NOUN
admet-2414	359	2	110	110	NUM
admet-2414	359	3	(	(	PUNCT
admet-2414	359	4	2002	2002	NUM
admet-2414	359	5	)	)	PUNCT
admet-2414	359	6	93	93	NUM
admet-2414	359	7	-	-	SYM
admet-2414	359	8	105	105	NUM
admet-2414	359	9	.	.	PUNCT
admet-2414	360	1	https://doi.org/10.1016/s00928674(02)00817-6	https://doi.org/10.1016/s00928674(02)00817-6	X
admet-2414	360	2	.	.	PUNCT
admet-2414	361	1	[	[	X
admet-2414	361	2	6	6	NUM
admet-2414	361	3	]	]	X
admet-2414	361	4	g.i	g.i	PROPN
admet-2414	361	5	.	.	PROPN
admet-2414	361	6	mazaira	mazaira	PROPN
admet-2414	361	7	,	,	PUNCT
admet-2414	361	8	g.	g.	PROPN
admet-2414	361	9	piwien	piwien	PROPN
admet-2414	361	10	pilipuk	pilipuk	PROPN
admet-2414	361	11	,	,	PUNCT
admet-2414	361	12	m.d	m.d	PROPN
admet-2414	361	13	.	.	PROPN
admet-2414	361	14	galigniana	galigniana	PROPN
admet-2414	361	15	.	.	PUNCT
admet-2414	362	1	corticosteroid	corticosteroid	ADJ
admet-2414	362	2	receptors	receptor	NOUN
admet-2414	362	3	as	as	ADP
admet-2414	362	4	a	a	DET
admet-2414	362	5	model	model	NOUN
admet-2414	362	6	for	for	ADP
admet-2414	362	7	the	the	DET
admet-2414	362	8	hsp90*immunophilin	hsp90*immunophilin	NOUN
admet-2414	362	9	-	-	PUNCT
admet-2414	362	10	based	base	VERB
admet-2414	362	11	transport	transport	NOUN
admet-2414	362	12	machinery	machinery	NOUN
admet-2414	362	13	.	.	PUNCT
admet-2414	363	1	trends	trend	NOUN
admet-2414	363	2	endocrinol	endocrinol	VERB
admet-2414	363	3	metab	metab	NOUN
admet-2414	363	4	32	32	NUM
admet-2414	363	5	(	(	PUNCT
admet-2414	363	6	2021	2021	NUM
admet-2414	363	7	)	)	PUNCT
admet-2414	363	8	827	827	NUM
admet-2414	363	9	-	-	SYM
admet-2414	363	10	838	838	NUM
admet-2414	363	11	.	.	PUNCT
admet-2414	364	1	https://doi.org/10.1016/j.tem.2021.07.005	https://doi.org/10.1016/j.tem.2021.07.005	PROPN
admet-2414	364	2	.	.	PUNCT
admet-2414	365	1	[	[	X
admet-2414	365	2	7	7	X
admet-2414	365	3	]	]	X
admet-2414	365	4	w.b	w.b	PROPN
admet-2414	365	5	.	.	PUNCT
admet-2414	365	6	pratt	pratt	PROPN
admet-2414	365	7	,	,	PUNCT
admet-2414	365	8	y.	y.	PROPN
admet-2414	365	9	morishima	morishima	PROPN
admet-2414	365	10	,	,	PUNCT
admet-2414	365	11	m.	m.	NOUN
admet-2414	365	12	murphy	murphy	PROPN
admet-2414	365	13	,	,	PUNCT
admet-2414	365	14	m.	m.	PROPN
admet-2414	365	15	harrell	harrell	PROPN
admet-2414	365	16	.	.	PUNCT
admet-2414	366	1	chaperoning	chaperone	VERB
admet-2414	366	2	of	of	ADP
admet-2414	366	3	glucocorticoid	glucocorticoid	ADJ
admet-2414	366	4	receptors	receptor	NOUN
admet-2414	366	5	.	.	PUNCT
admet-2414	367	1	handb	handb	NOUN
admet-2414	367	2	exp	exp	NOUN
admet-2414	367	3	pharmacol	pharmacol	PROPN
admet-2414	367	4	(	(	PUNCT
admet-2414	367	5	2006	2006	NUM
admet-2414	367	6	)	)	PUNCT
admet-2414	367	7	111	111	NUM
admet-2414	367	8	-	-	SYM
admet-2414	367	9	138	138	NUM
admet-2414	367	10	.	.	PUNCT
admet-2414	368	1	https://doi.org/10.1007/3-540-29717-0_5	https://doi.org/10.1007/3-540-29717-0_5	PROPN
admet-2414	368	2	.	.	PUNCT
admet-2414	369	1	[	[	X
admet-2414	369	2	8	8	X
admet-2414	369	3	]	]	PUNCT
admet-2414	369	4	s.	s.	PROPN
admet-2414	369	5	vettorazzi	vettorazzi	PROPN
admet-2414	369	6	,	,	PUNCT
admet-2414	369	7	d.	d.	PROPN
admet-2414	369	8	nalbantoglu	nalbantoglu	PROPN
admet-2414	369	9	,	,	PUNCT
admet-2414	369	10	j.c.m	j.c.m	PROPN
admet-2414	369	11	.	.	PUNCT
admet-2414	370	1	gebhardt	gebhardt	PROPN
admet-2414	370	2	,	,	PUNCT
admet-2414	370	3	j.	j.	PROPN
admet-2414	370	4	tuckermann	tuckermann	PROPN
admet-2414	370	5	.	.	PUNCT
admet-2414	371	1	a	a	DET
admet-2414	371	2	guide	guide	NOUN
admet-2414	371	3	to	to	ADP
admet-2414	371	4	changing	change	VERB
admet-2414	371	5	paradigms	paradigm	NOUN
admet-2414	371	6	of	of	ADP
admet-2414	371	7	glucocorticoid	glucocorticoid	ADJ
admet-2414	371	8	receptor	receptor	NOUN
admet-2414	371	9	function	function	NOUN
admet-2414	371	10	-	-	PUNCT
admet-2414	371	11	a	a	DET
admet-2414	371	12	model	model	NOUN
admet-2414	371	13	system	system	NOUN
admet-2414	371	14	for	for	ADP
admet-2414	371	15	genome	genome	NOUN
admet-2414	371	16	regulation	regulation	NOUN
admet-2414	371	17	and	and	CCONJ
admet-2414	371	18	physiology	physiology	NOUN
admet-2414	371	19	.	.	PUNCT
admet-2414	372	1	febs	febs	PROPN
admet-2414	372	2	j	j	PROPN
admet-2414	372	3	289	289	NUM
admet-2414	372	4	(	(	PUNCT
admet-2414	372	5	2022	2022	NUM
admet-2414	372	6	)	)	PUNCT
admet-2414	372	7	5718	5718	NUM
admet-2414	372	8	-	-	SYM
admet-2414	372	9	5743	5743	NUM
admet-2414	372	10	.	.	PUNCT
admet-2414	373	1	https://doi.org/10.1111/febs.16100	https://doi.org/10.1111/febs.16100	PROPN
admet-2414	373	2	.	.	PUNCT
admet-2414	374	1	[	[	X
admet-2414	374	2	9	9	NUM
admet-2414	374	3	]	]	X
admet-2414	374	4	s.h	s.h	PROPN
admet-2414	374	5	.	.	PROPN
admet-2414	374	6	meijsing	meijsing	PROPN
admet-2414	374	7	,	,	PUNCT
admet-2414	374	8	m.a	m.a	PROPN
admet-2414	374	9	.	.	PROPN
admet-2414	374	10	pufall	pufall	PROPN
admet-2414	374	11	,	,	PUNCT
admet-2414	374	12	a.y	a.y	PROPN
admet-2414	374	13	.	.	PUNCT
admet-2414	375	1	so	so	ADV
admet-2414	375	2	,	,	PUNCT
admet-2414	375	3	d.l	d.l	PROPN
admet-2414	375	4	.	.	PROPN
admet-2414	375	5	bates	bates	PROPN
admet-2414	375	6	,	,	PUNCT
admet-2414	375	7	l.	l.	PROPN
admet-2414	375	8	chen	chen	PROPN
admet-2414	375	9	,	,	PUNCT
admet-2414	375	10	k.r	k.r	PROPN
admet-2414	375	11	.	.	PROPN
admet-2414	375	12	yamamoto	yamamoto	PROPN
admet-2414	375	13	.	.	PUNCT
admet-2414	376	1	dna	dna	PROPN
admet-2414	376	2	binding	bind	VERB
admet-2414	376	3	site	site	NOUN
admet-2414	376	4	sequence	sequence	NOUN
admet-2414	376	5	directs	direct	VERB
admet-2414	376	6	glucocorticoid	glucocorticoid	ADJ
admet-2414	376	7	receptor	receptor	NOUN
admet-2414	376	8	structure	structure	NOUN
admet-2414	376	9	and	and	CCONJ
admet-2414	376	10	activity	activity	NOUN
admet-2414	376	11	.	.	PUNCT
admet-2414	377	1	science	science	NOUN
admet-2414	377	2	324	324	NUM
admet-2414	377	3	(	(	PUNCT
admet-2414	377	4	2009	2009	NUM
admet-2414	377	5	)	)	PUNCT
admet-2414	377	6	407	407	NUM
admet-2414	377	7	-	-	SYM
admet-2414	377	8	410	410	NUM
admet-2414	377	9	.	.	PUNCT
admet-2414	377	10	https://doi.org/10.1126/science.1164265	https://doi.org/10.1126/science.1164265	NOUN
admet-2414	377	11	.	.	PUNCT
admet-2414	378	1	[	[	X
admet-2414	378	2	10	10	NUM
admet-2414	378	3	]	]	X
admet-2414	378	4	f.	f.	PROPN
admet-2414	378	5	frank	frank	PROPN
admet-2414	378	6	,	,	PUNCT
admet-2414	378	7	e.a	e.a	PROPN
admet-2414	378	8	.	.	PROPN
admet-2414	378	9	ortlund	ortlund	PROPN
admet-2414	378	10	,	,	PUNCT
admet-2414	378	11	x.	x.	PROPN
admet-2414	378	12	liu	liu	PROPN
admet-2414	378	13	.	.	PUNCT
admet-2414	379	1	structural	structural	ADJ
admet-2414	379	2	insights	insight	NOUN
admet-2414	379	3	into	into	ADP
admet-2414	379	4	glucocorticoid	glucocorticoid	ADJ
admet-2414	379	5	receptor	receptor	NOUN
admet-2414	379	6	function	function	NOUN
admet-2414	379	7	.	.	PUNCT
admet-2414	380	1	biochem	biochem	PROPN
admet-2414	380	2	soc	soc	PROPN
admet-2414	380	3	trans	trans	PROPN
admet-2414	380	4	49	49	NUM
admet-2414	380	5	(	(	PUNCT
admet-2414	380	6	2021	2021	NUM
admet-2414	380	7	)	)	PUNCT
admet-2414	380	8	2333	2333	NUM
admet-2414	380	9	-	-	SYM
admet-2414	380	10	2343	2343	NUM
admet-2414	380	11	.	.	PUNCT
admet-2414	381	1	https://doi.org/10.1042/bst20210419	https://doi.org/10.1042/bst20210419	PROPN
admet-2414	381	2	.	.	PUNCT
admet-2414	382	1	[	[	X
admet-2414	382	2	11	11	NUM
admet-2414	382	3	]	]	PUNCT
admet-2414	382	4	the	the	DET
admet-2414	382	5	top	top	ADJ
admet-2414	382	6	300	300	NUM
admet-2414	382	7	drugs	drug	NOUN
admet-2414	382	8	of	of	ADP
admet-2414	382	9	2021	2021	NUM
admet-2414	382	10	,	,	PUNCT
admet-2414	382	11	https://clincalc.com/drugstats/top300drugs.aspx	https://clincalc.com/drugstats/top300drugs.aspx	PROPN
admet-2414	382	12	.	.	PUNCT
admet-2414	383	1	https://pub.iapchem.org/ojs/index.php/admet/article/view/2414	https://pub.iapchem.org/ojs/index.php/admet/article/view/2414	VERB
admet-2414	383	2	https://www.ncbi.nlm.nih.gov/pubmed/5699052	https://www.ncbi.nlm.nih.gov/pubmed/5699052	PRON
admet-2414	384	1	https://doi.org/10.1016/j.steroids.2004.12.002	https://doi.org/10.1016/j.steroids.2004.12.002	NOUN
admet-2414	384	2	https://doi.org/10.1016/0022-4731(72)90103-3	https://doi.org/10.1016/0022-4731(72)90103-3	PRON
admet-2414	384	3	https://doi.org/10.1016/0022-4731(89)90069-1	https://doi.org/10.1016/0022-4731(89)90069-1	PRON
admet-2414	384	4	https://doi.org/10.1016/s0092-8674(02)00817-6	https://doi.org/10.1016/s0092-8674(02)00817-6	PROPN
admet-2414	384	5	https://doi.org/10.1016/s0092-8674(02)00817-6	https://doi.org/10.1016/s0092-8674(02)00817-6	AUX
admet-2414	384	6	https://doi.org/10.1016/j.tem.2021.07.005	https://doi.org/10.1016/j.tem.2021.07.005	PROPN
admet-2414	384	7	https://doi.org/10.1007/3-540-29717-0_5	https://doi.org/10.1007/3-540-29717-0_5	PROPN
admet-2414	384	8	https://doi.org/10.1111/febs.16100	https://doi.org/10.1111/febs.16100	PROPN
admet-2414	384	9	https://doi.org/10.1126/science.1164265	https://doi.org/10.1126/science.1164265	NOUN
admet-2414	384	10	https://doi.org/10.1042/bst20210419	https://doi.org/10.1042/bst20210419	PROPN
admet-2414	384	11	https://clincalc.com/drugstats/top300drugs.aspx	https://clincalc.com/drugstats/top300drugs.aspx	X
admet-2414	384	12	admet	admet	PROPN
admet-2414	384	13	&	&	CCONJ
admet-2414	384	14	dmpk	dmpk	PROPN
admet-2414	384	15	12(6	12(6	NUM
admet-2414	384	16	)	)	PUNCT
admet-2414	384	17	(	(	PUNCT
admet-2414	384	18	2024	2024	NUM
admet-2414	384	19	)	)	PUNCT
admet-2414	384	20	971	971	NUM
admet-2414	384	21	-	-	SYM
admet-2414	384	22	989	989	NUM
admet-2414	384	23	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	384	24	/	/	SYM
admet-2414	384	25	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	384	26	of	of	ADP
admet-2414	384	27	glucocorticoids	glucocorticoid	NOUN
admet-2414	384	28	doi	doi	NOUN
admet-2414	384	29	:	:	PUNCT
admet-2414	384	30	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	384	31	987	987	NUM
admet-2414	385	1	[	[	X
admet-2414	385	2	12	12	NUM
admet-2414	385	3	]	]	X
admet-2414	385	4	g.r	g.r	PROPN
admet-2414	385	5	.	.	PROPN
admet-2414	385	6	bernard	bernard	PROPN
admet-2414	385	7	,	,	PUNCT
admet-2414	385	8	j.m	j.m	PROPN
admet-2414	385	9	.	.	PROPN
admet-2414	385	10	luce	luce	PROPN
admet-2414	385	11	,	,	PUNCT
admet-2414	385	12	c.l	c.l	PROPN
admet-2414	385	13	.	.	PROPN
admet-2414	385	14	sprung	sprung	PROPN
admet-2414	385	15	,	,	PUNCT
admet-2414	385	16	j.e	j.e	PROPN
admet-2414	385	17	.	.	PROPN
admet-2414	385	18	rinaldo	rinaldo	PROPN
admet-2414	385	19	,	,	PUNCT
admet-2414	385	20	r.m	r.m	PROPN
admet-2414	385	21	.	.	PROPN
admet-2414	385	22	tate	tate	PROPN
admet-2414	385	23	,	,	PUNCT
admet-2414	385	24	w.j	w.j	PROPN
admet-2414	385	25	.	.	PROPN
admet-2414	385	26	sibbald	sibbald	PROPN
admet-2414	385	27	,	,	PUNCT
admet-2414	385	28	k.	k.	PROPN
admet-2414	385	29	kariman	kariman	PROPN
admet-2414	385	30	,	,	PUNCT
admet-2414	385	31	s.	s.	PROPN
admet-2414	385	32	higgins	higgins	PROPN
admet-2414	385	33	,	,	PUNCT
admet-2414	385	34	r.	r.	PROPN
admet-2414	385	35	bradley	bradley	PROPN
admet-2414	385	36	,	,	PUNCT
admet-2414	385	37	c.a	c.a	PROPN
admet-2414	385	38	.	.	PROPN
admet-2414	385	39	metz	metz	PROPN
admet-2414	385	40	,	,	PUNCT
admet-2414	385	41	et	et	PROPN
admet-2414	385	42	al	al	PROPN
admet-2414	385	43	.	.	PROPN
admet-2414	385	44	high	high	ADJ
admet-2414	385	45	-	-	PUNCT
admet-2414	385	46	dose	dose	NOUN
admet-2414	385	47	corticosteroids	corticosteroid	NOUN
admet-2414	385	48	in	in	ADP
admet-2414	385	49	patients	patient	NOUN
admet-2414	385	50	with	with	ADP
admet-2414	385	51	the	the	DET
admet-2414	385	52	adult	adult	NOUN
admet-2414	385	53	respiratory	respiratory	ADJ
admet-2414	385	54	distress	distress	NOUN
admet-2414	385	55	syndrome	syndrome	NOUN
admet-2414	385	56	.	.	PUNCT
admet-2414	386	1	n	n	PROPN
admet-2414	386	2	engl	engl	PROPN
admet-2414	386	3	j	j	PROPN
admet-2414	386	4	med	me	VERB
admet-2414	386	5	317	317	NUM
admet-2414	386	6	(	(	PUNCT
admet-2414	386	7	1987	1987	NUM
admet-2414	386	8	)	)	PUNCT
admet-2414	386	9	1565	1565	NUM
admet-2414	386	10	-	-	SYM
admet-2414	386	11	1570	1570	NUM
admet-2414	386	12	.	.	PUNCT
admet-2414	387	1	https://doi.org/10.1056/nejm198712173172504	https://doi.org/10.1056/nejm198712173172504	NOUN
admet-2414	387	2	.	.	PUNCT
admet-2414	388	1	[	[	X
admet-2414	388	2	13	13	NUM
admet-2414	388	3	]	]	PUNCT
admet-2414	388	4	a.	a.	NOUN
admet-2414	388	5	caplan	caplan	PROPN
admet-2414	388	6	,	,	PUNCT
admet-2414	388	7	n.	n.	PROPN
admet-2414	388	8	fett	fett	PROPN
admet-2414	388	9	,	,	PUNCT
admet-2414	388	10	m.	m.	NOUN
admet-2414	388	11	rosenbach	rosenbach	NOUN
admet-2414	388	12	,	,	PUNCT
admet-2414	388	13	v.p	v.p	PROPN
admet-2414	388	14	.	.	PROPN
admet-2414	388	15	werth	werth	PROPN
admet-2414	388	16	,	,	PUNCT
admet-2414	388	17	r.g	r.g	PROPN
admet-2414	388	18	.	.	PROPN
admet-2414	388	19	micheletti	micheletti	PROPN
admet-2414	388	20	.	.	PUNCT
admet-2414	388	21	prevention	prevention	NOUN
admet-2414	388	22	and	and	CCONJ
admet-2414	388	23	management	management	NOUN
admet-2414	388	24	of	of	ADP
admet-2414	388	25	glucocorticoid	glucocorticoid	NOUN
admet-2414	388	26	-	-	PUNCT
admet-2414	388	27	induced	induce	VERB
admet-2414	388	28	side	side	NOUN
admet-2414	388	29	effects	effect	NOUN
admet-2414	388	30	:	:	PUNCT
admet-2414	388	31	a	a	DET
admet-2414	388	32	comprehensive	comprehensive	ADJ
admet-2414	388	33	review	review	NOUN
admet-2414	388	34	:	:	PUNCT
admet-2414	388	35	a	a	DET
admet-2414	388	36	review	review	NOUN
admet-2414	388	37	of	of	ADP
admet-2414	388	38	glucocorticoid	glucocorticoid	ADJ
admet-2414	388	39	pharmacology	pharmacology	NOUN
admet-2414	388	40	and	and	CCONJ
admet-2414	388	41	bone	bone	NOUN
admet-2414	388	42	health	health	NOUN
admet-2414	388	43	.	.	PUNCT
admet-2414	389	1	j	j	PROPN
admet-2414	389	2	am	be	AUX
admet-2414	389	3	acad	acad	ADJ
admet-2414	389	4	dermatol	dermatol	NOUN
admet-2414	389	5	76	76	NUM
admet-2414	389	6	(	(	PUNCT
admet-2414	389	7	2017	2017	NUM
admet-2414	389	8	)	)	PUNCT
admet-2414	389	9	1	1	NUM
admet-2414	389	10	-	-	SYM
admet-2414	389	11	9	9	NUM
admet-2414	389	12	.	.	PUNCT
admet-2414	389	13	https://doi.org/10.1016/j.jaad.2016.01.062	https://doi.org/10.1016/j.jaad.2016.01.062	PRON
admet-2414	389	14	.	.	PUNCT
admet-2414	390	1	[	[	X
admet-2414	390	2	14	14	NUM
admet-2414	390	3	]	]	X
admet-2414	390	4	w.	w.	PROPN
admet-2414	390	5	schumer	schumer	PROPN
admet-2414	390	6	.	.	PUNCT
admet-2414	391	1	steroids	steroid	NOUN
admet-2414	391	2	in	in	ADP
admet-2414	391	3	the	the	DET
admet-2414	391	4	treatment	treatment	NOUN
admet-2414	391	5	of	of	ADP
admet-2414	391	6	clinical	clinical	ADJ
admet-2414	391	7	septic	septic	ADJ
admet-2414	391	8	shock	shock	NOUN
admet-2414	391	9	.	.	PUNCT
admet-2414	392	1	ann	ann	PROPN
admet-2414	392	2	surg	surg	PROPN
admet-2414	392	3	184	184	NUM
admet-2414	392	4	(	(	PUNCT
admet-2414	392	5	1976	1976	NUM
admet-2414	392	6	)	)	PUNCT
admet-2414	392	7	333	333	NUM
admet-2414	392	8	-	-	SYM
admet-2414	392	9	341	341	NUM
admet-2414	392	10	.	.	PUNCT
admet-2414	392	11	https://doi.org/10.1097/00000658-197609000-00011	https://doi.org/10.1097/00000658-197609000-00011	PROPN
admet-2414	392	12	.	.	PUNCT
admet-2414	393	1	[	[	X
admet-2414	393	2	15	15	NUM
admet-2414	393	3	]	]	X
admet-2414	393	4	c.d	c.d	PROPN
admet-2414	393	5	.	.	PROPN
admet-2414	393	6	osterlund	osterlund	PROPN
admet-2414	393	7	,	,	PUNCT
admet-2414	393	8	m.	m.	NOUN
admet-2414	393	9	rodriguez	rodriguez	PROPN
admet-2414	393	10	-	-	PUNCT
admet-2414	393	11	santiago	santiago	PROPN
admet-2414	393	12	,	,	PUNCT
admet-2414	393	13	e.r	e.r	PROPN
admet-2414	393	14	.	.	PROPN
admet-2414	393	15	woodruff	woodruff	PROPN
admet-2414	393	16	,	,	PUNCT
admet-2414	393	17	r.j	r.j	PROPN
admet-2414	393	18	.	.	PROPN
admet-2414	393	19	newsom	newsom	PROPN
admet-2414	393	20	,	,	PUNCT
admet-2414	393	21	a.p	a.p	PROPN
admet-2414	393	22	.	.	PROPN
admet-2414	393	23	chadayammuri	chadayammuri	PROPN
admet-2414	393	24	,	,	PUNCT
admet-2414	393	25	r.l	r.l	PROPN
admet-2414	393	26	.	.	PROPN
admet-2414	393	27	spencer	spencer	PROPN
admet-2414	393	28	.	.	PUNCT
admet-2414	394	1	glucocorticoid	glucocorticoid	ADJ
admet-2414	394	2	fast	fast	ADJ
admet-2414	394	3	feedback	feedback	NOUN
admet-2414	394	4	inhibition	inhibition	NOUN
admet-2414	394	5	of	of	ADP
admet-2414	394	6	stress	stress	NOUN
admet-2414	394	7	-	-	PUNCT
admet-2414	394	8	induced	induce	VERB
admet-2414	394	9	acth	acth	ADJ
admet-2414	394	10	secretion	secretion	NOUN
admet-2414	394	11	in	in	ADP
admet-2414	394	12	the	the	DET
admet-2414	394	13	male	male	ADJ
admet-2414	394	14	rat	rat	NOUN
admet-2414	394	15	:	:	PUNCT
admet-2414	394	16	rate	rate	NOUN
admet-2414	394	17	independence	independence	NOUN
admet-2414	394	18	and	and	CCONJ
admet-2414	394	19	stress	stress	NOUN
admet-2414	394	20	-	-	PUNCT
admet-2414	394	21	state	state	NOUN
admet-2414	394	22	resistance	resistance	NOUN
admet-2414	394	23	.	.	PUNCT
admet-2414	395	1	endocrinology	endocrinology	NOUN
admet-2414	395	2	157	157	NUM
admet-2414	395	3	(	(	PUNCT
admet-2414	395	4	2016	2016	NUM
admet-2414	395	5	)	)	PUNCT
admet-2414	395	6	2785	2785	NUM
admet-2414	395	7	-	-	SYM
admet-2414	395	8	2798	2798	NUM
admet-2414	395	9	.	.	PUNCT
admet-2414	396	1	https://doi.org/10.1210/en.2016-1123	https://doi.org/10.1210/en.2016-1123	NOUN
admet-2414	396	2	.	.	PUNCT
admet-2414	397	1	[	[	X
admet-2414	397	2	16	16	NUM
admet-2414	397	3	]	]	X
admet-2414	397	4	j.f	j.f	PROPN
admet-2414	397	5	.	.	PROPN
admet-2414	397	6	arnal	arnal	PROPN
admet-2414	397	7	,	,	PUNCT
admet-2414	397	8	c.	c.	PROPN
admet-2414	397	9	fontaine	fontaine	PROPN
admet-2414	397	10	,	,	PUNCT
admet-2414	397	11	m.	m.	NOUN
admet-2414	397	12	adlanmerini	adlanmerini	PROPN
admet-2414	397	13	,	,	PUNCT
admet-2414	397	14	f.	f.	PROPN
admet-2414	397	15	lenfant	lenfant	PROPN
admet-2414	397	16	.	.	PUNCT
admet-2414	398	1	special	special	ADJ
admet-2414	398	2	issue	issue	NOUN
admet-2414	398	3	on	on	ADP
admet-2414	398	4	non	non	ADJ
admet-2414	398	5	-	-	ADJ
admet-2414	398	6	genomic	genomic	ADJ
admet-2414	398	7	actions	action	NOUN
admet-2414	398	8	of	of	ADP
admet-2414	398	9	nuclear	nuclear	ADJ
admet-2414	398	10	receptors	receptor	NOUN
admet-2414	398	11	:	:	PUNCT
admet-2414	398	12	an	an	DET
admet-2414	398	13	evolutionary	evolutionary	ADJ
admet-2414	398	14	and	and	CCONJ
admet-2414	398	15	physiological	physiological	ADJ
admet-2414	398	16	perspective	perspective	NOUN
admet-2414	398	17	.	.	PUNCT
admet-2414	399	1	mol	mol	ADP
admet-2414	399	2	cell	cell	NOUN
admet-2414	399	3	endocrinol	endocrinol	NOUN
admet-2414	399	4	564	564	NUM
admet-2414	399	5	(	(	PUNCT
admet-2414	399	6	2023	2023	NUM
admet-2414	399	7	)	)	PUNCT
admet-2414	399	8	111884	111884	NUM
admet-2414	399	9	.	.	PUNCT
admet-2414	400	1	https://doi.org/10.1016/j.mce.2023.111884	https://doi.org/10.1016/j.mce.2023.111884	X
admet-2414	400	2	.	.	PUNCT
admet-2414	401	1	[	[	X
admet-2414	401	2	17	17	NUM
admet-2414	401	3	]	]	X
admet-2414	401	4	s.h	s.h	PROPN
admet-2414	401	5	.	.	PROPN
admet-2414	401	6	meijsing	meijsing	PROPN
admet-2414	401	7	,	,	PUNCT
admet-2414	401	8	c.	c.	PROPN
admet-2414	401	9	elbi	elbi	PROPN
admet-2414	401	10	,	,	PUNCT
admet-2414	401	11	h.f	h.f	PROPN
admet-2414	401	12	.	.	PROPN
admet-2414	401	13	luecke	luecke	PROPN
admet-2414	401	14	,	,	PUNCT
admet-2414	401	15	g.l	g.l	PROPN
admet-2414	401	16	.	.	PROPN
admet-2414	401	17	hager	hager	PROPN
admet-2414	401	18	,	,	PUNCT
admet-2414	401	19	k.r	k.r	PROPN
admet-2414	401	20	.	.	PROPN
admet-2414	401	21	yamamoto	yamamoto	PROPN
admet-2414	401	22	.	.	PUNCT
admet-2414	402	1	the	the	DET
admet-2414	402	2	ligand	ligand	ADJ
admet-2414	402	3	binding	bind	VERB
admet-2414	402	4	domain	domain	NOUN
admet-2414	402	5	controls	control	VERB
admet-2414	402	6	glucocorticoid	glucocorticoid	ADJ
admet-2414	402	7	receptor	receptor	NOUN
admet-2414	402	8	dynamics	dynamic	NOUN
admet-2414	402	9	independent	independent	ADJ
admet-2414	402	10	of	of	ADP
admet-2414	402	11	ligand	ligand	ADJ
admet-2414	402	12	release	release	NOUN
admet-2414	402	13	.	.	PUNCT
admet-2414	403	1	mol	mol	ADP
admet-2414	403	2	cell	cell	NOUN
admet-2414	403	3	biol	biol	NOUN
admet-2414	403	4	27	27	NUM
admet-2414	403	5	(	(	PUNCT
admet-2414	403	6	2007	2007	NUM
admet-2414	403	7	)	)	PUNCT
admet-2414	403	8	2442	2442	NUM
admet-2414	403	9	-	-	SYM
admet-2414	403	10	2451	2451	NUM
admet-2414	403	11	.	.	PUNCT
admet-2414	404	1	https://doi.org/10.1128/mcb.01570-06	https://doi.org/10.1128/mcb.01570-06	NOUN
admet-2414	404	2	.	.	PUNCT
admet-2414	405	1	[	[	X
admet-2414	405	2	18	18	NUM
admet-2414	405	3	]	]	PUNCT
admet-2414	405	4	j.	j.	PROPN
admet-2414	405	5	yang	yang	PROPN
admet-2414	405	6	,	,	PUNCT
admet-2414	405	7	j.	j.	PROPN
admet-2414	405	8	liu	liu	PROPN
admet-2414	405	9	,	,	PUNCT
admet-2414	405	10	d.b	d.b	PROPN
admet-2414	405	11	.	.	PROPN
admet-2414	405	12	defranco	defranco	PROPN
admet-2414	405	13	.	.	PUNCT
admet-2414	405	14	subnuclear	subnuclear	PROPN
admet-2414	405	15	trafficking	trafficking	NOUN
admet-2414	405	16	of	of	ADP
admet-2414	405	17	glucocorticoid	glucocorticoid	ADJ
admet-2414	405	18	receptors	receptor	NOUN
admet-2414	405	19	in	in	ADP
admet-2414	405	20	vitro	vitro	X
admet-2414	405	21	:	:	PUNCT
admet-2414	405	22	chromatin	chromatin	NOUN
admet-2414	405	23	recycling	recycling	NOUN
admet-2414	405	24	and	and	CCONJ
admet-2414	405	25	nuclear	nuclear	ADJ
admet-2414	405	26	export	export	NOUN
admet-2414	405	27	.	.	PUNCT
admet-2414	406	1	j	j	PROPN
admet-2414	406	2	cell	cell	NOUN
admet-2414	406	3	biol	biol	NOUN
admet-2414	406	4	137	137	NUM
admet-2414	406	5	(	(	PUNCT
admet-2414	406	6	1997	1997	NUM
admet-2414	406	7	)	)	PUNCT
admet-2414	406	8	523	523	NUM
admet-2414	406	9	-	-	SYM
admet-2414	406	10	538	538	NUM
admet-2414	406	11	.	.	PUNCT
admet-2414	406	12	https://doi.org/10.1083/jcb.137.3.523	https://doi.org/10.1083/jcb.137.3.523	NOUN
admet-2414	406	13	.	.	PUNCT
admet-2414	407	1	[	[	X
admet-2414	407	2	19	19	NUM
admet-2414	407	3	]	]	X
admet-2414	407	4	r.j	r.j	PROPN
admet-2414	407	5	.	.	PROPN
admet-2414	407	6	hache	hache	PROPN
admet-2414	407	7	,	,	PUNCT
admet-2414	407	8	r.	r.	PROPN
admet-2414	407	9	tse	tse	PROPN
admet-2414	407	10	,	,	PUNCT
admet-2414	407	11	t.	t.	PROPN
admet-2414	407	12	reich	reich	PROPN
admet-2414	407	13	,	,	PUNCT
admet-2414	407	14	j.g	j.g	PROPN
admet-2414	407	15	.	.	PROPN
admet-2414	407	16	savory	savory	NOUN
admet-2414	407	17	,	,	PUNCT
admet-2414	407	18	y.a	y.a	PROPN
admet-2414	407	19	.	.	PROPN
admet-2414	407	20	lefebvre	lefebvre	PROPN
admet-2414	407	21	.	.	PUNCT
admet-2414	408	1	nucleocytoplasmic	nucleocytoplasmic	ADJ
admet-2414	408	2	trafficking	trafficking	NOUN
admet-2414	408	3	of	of	ADP
admet-2414	408	4	steroid	steroid	NOUN
admet-2414	408	5	-	-	PUNCT
admet-2414	408	6	free	free	ADJ
admet-2414	408	7	glucocorticoid	glucocorticoid	ADJ
admet-2414	408	8	receptor	receptor	NOUN
admet-2414	408	9	.	.	PUNCT
admet-2414	409	1	j	j	PROPN
admet-2414	409	2	biol	biol	PROPN
admet-2414	409	3	chem	chem	NOUN
admet-2414	409	4	274	274	NUM
admet-2414	409	5	(	(	PUNCT
admet-2414	409	6	1999	1999	NUM
admet-2414	409	7	)	)	PUNCT
admet-2414	409	8	1432	1432	NUM
admet-2414	409	9	-	-	SYM
admet-2414	409	10	1439	1439	NUM
admet-2414	409	11	.	.	PUNCT
admet-2414	410	1	https://doi.org/10.1074/jbc.274.3.1432	https://doi.org/10.1074/jbc.274.3.1432	NUM
admet-2414	410	2	.	.	PUNCT
admet-2414	411	1	[	[	X
admet-2414	411	2	20	20	NUM
admet-2414	411	3	]	]	PUNCT
admet-2414	411	4	a.	a.	NOUN
admet-2414	411	5	munck	munck	NOUN
admet-2414	411	6	,	,	PUNCT
admet-2414	411	7	g.r	g.r	PROPN
admet-2414	411	8	.	.	PUNCT
admet-2414	411	9	crabtree	crabtree	PROPN
admet-2414	411	10	,	,	PUNCT
admet-2414	411	11	k.a	k.a	PROPN
admet-2414	411	12	.	.	PROPN
admet-2414	411	13	smith	smith	PROPN
admet-2414	411	14	.	.	PUNCT
admet-2414	411	15	effects	effect	NOUN
admet-2414	411	16	and	and	CCONJ
admet-2414	411	17	receptors	receptor	NOUN
admet-2414	411	18	of	of	ADP
admet-2414	411	19	glucocorticoids	glucocorticoid	NOUN
admet-2414	411	20	in	in	ADP
admet-2414	411	21	rat	rat	NOUN
admet-2414	411	22	thymus	thymus	ADJ
admet-2414	411	23	cells	cell	NOUN
admet-2414	411	24	and	and	CCONJ
admet-2414	411	25	human	human	ADJ
admet-2414	411	26	peripheral	peripheral	ADJ
admet-2414	411	27	lymphocytes	lymphocyte	NOUN
admet-2414	411	28	.	.	PUNCT
admet-2414	412	1	j	j	PROPN
admet-2414	412	2	toxicol	toxicol	PROPN
admet-2414	412	3	environ	environ	PROPN
admet-2414	412	4	health	health	PROPN
admet-2414	412	5	4	4	NUM
admet-2414	412	6	(	(	PUNCT
admet-2414	412	7	1978	1978	NUM
admet-2414	412	8	)	)	PUNCT
admet-2414	412	9	409	409	NUM
admet-2414	412	10	-	-	SYM
admet-2414	412	11	425	425	NUM
admet-2414	412	12	.	.	PUNCT
admet-2414	412	13	https://doi.org/10.1080/15287397809529668	https://doi.org/10.1080/15287397809529668	NOUN
admet-2414	412	14	.	.	PUNCT
admet-2414	413	1	[	[	X
admet-2414	413	2	21	21	NUM
admet-2414	413	3	]	]	X
admet-2414	413	4	h.	h.	PROPN
admet-2414	413	5	htun	htun	PROPN
admet-2414	413	6	,	,	PUNCT
admet-2414	413	7	j.	j.	PROPN
admet-2414	413	8	barsony	barsony	PROPN
admet-2414	413	9	,	,	PUNCT
admet-2414	413	10	i.	i.	PROPN
admet-2414	413	11	renyi	renyi	PROPN
admet-2414	413	12	,	,	PUNCT
admet-2414	413	13	d.l	d.l	PROPN
admet-2414	413	14	.	.	PROPN
admet-2414	413	15	gould	gould	PROPN
admet-2414	413	16	,	,	PUNCT
admet-2414	413	17	g.l	g.l	PROPN
admet-2414	413	18	.	.	PROPN
admet-2414	413	19	hager	hager	PROPN
admet-2414	413	20	.	.	PUNCT
admet-2414	414	1	visualization	visualization	NOUN
admet-2414	414	2	of	of	ADP
admet-2414	414	3	glucocorticoid	glucocorticoid	ADJ
admet-2414	414	4	receptor	receptor	NOUN
admet-2414	414	5	translocation	translocation	NOUN
admet-2414	414	6	and	and	CCONJ
admet-2414	414	7	intranuclear	intranuclear	NOUN
admet-2414	414	8	organization	organization	NOUN
admet-2414	414	9	in	in	ADP
admet-2414	414	10	living	living	NOUN
admet-2414	414	11	cells	cell	NOUN
admet-2414	414	12	with	with	ADP
admet-2414	414	13	a	a	DET
admet-2414	414	14	green	green	ADJ
admet-2414	414	15	fluorescent	fluorescent	ADJ
admet-2414	414	16	protein	protein	NOUN
admet-2414	414	17	chimera	chimera	NOUN
admet-2414	414	18	.	.	PUNCT
admet-2414	415	1	proc	proc	PROPN
admet-2414	415	2	natl	natl	PROPN
admet-2414	415	3	acad	acad	PROPN
admet-2414	415	4	sci	sci	PROPN
admet-2414	415	5	u	u	PROPN
admet-2414	415	6	s	s	PROPN
admet-2414	415	7	a	a	PRON
admet-2414	415	8	93	93	NUM
admet-2414	415	9	(	(	PUNCT
admet-2414	415	10	1996	1996	NUM
admet-2414	415	11	)	)	PUNCT
admet-2414	415	12	4845	4845	NUM
admet-2414	415	13	-	-	SYM
admet-2414	415	14	4850	4850	NUM
admet-2414	415	15	.	.	PUNCT
admet-2414	416	1	https://doi.org/10.1073/pnas.93.10.4845	https://doi.org/10.1073/pnas.93.10.4845	PROPN
admet-2414	416	2	.	.	PUNCT
admet-2414	417	1	[	[	X
admet-2414	417	2	22	22	NUM
admet-2414	417	3	]	]	X
admet-2414	417	4	p.c	p.c	PROPN
admet-2414	417	5	.	.	PROPN
admet-2414	417	6	echeverria	echeverria	PROPN
admet-2414	417	7	,	,	PUNCT
admet-2414	417	8	g.	g.	PROPN
admet-2414	417	9	mazaira	mazaira	PROPN
admet-2414	417	10	,	,	PUNCT
admet-2414	417	11	a.	a.	PROPN
admet-2414	417	12	erlejman	erlejman	PROPN
admet-2414	417	13	,	,	PUNCT
admet-2414	417	14	c.	c.	PROPN
admet-2414	417	15	gomez	gomez	PROPN
admet-2414	417	16	-	-	PUNCT
admet-2414	417	17	sanchez	sanchez	PROPN
admet-2414	417	18	,	,	PUNCT
admet-2414	417	19	g.	g.	PROPN
admet-2414	417	20	piwien	piwien	PROPN
admet-2414	417	21	pilipuk	pilipuk	PROPN
admet-2414	417	22	,	,	PUNCT
admet-2414	417	23	m.d	m.d	PROPN
admet-2414	417	24	.	.	PROPN
admet-2414	417	25	galigniana	galigniana	PROPN
admet-2414	417	26	.	.	PUNCT
admet-2414	418	1	nuclear	nuclear	ADJ
admet-2414	418	2	import	import	NOUN
admet-2414	418	3	of	of	ADP
admet-2414	418	4	the	the	DET
admet-2414	418	5	glucocorticoid	glucocorticoid	ADJ
admet-2414	418	6	receptor	receptor	NOUN
admet-2414	418	7	-	-	PUNCT
admet-2414	418	8	hsp90	hsp90	ADJ
admet-2414	418	9	complex	complex	NOUN
admet-2414	418	10	through	through	ADP
admet-2414	418	11	the	the	DET
admet-2414	418	12	nuclear	nuclear	ADJ
admet-2414	418	13	pore	pore	ADJ
admet-2414	418	14	complex	complex	NOUN
admet-2414	418	15	is	be	AUX
admet-2414	418	16	mediated	mediate	VERB
admet-2414	418	17	by	by	ADP
admet-2414	418	18	its	its	PRON
admet-2414	418	19	interaction	interaction	NOUN
admet-2414	418	20	with	with	ADP
admet-2414	418	21	nup62	nup62	ADV
admet-2414	418	22	and	and	CCONJ
admet-2414	418	23	importin	importin	VERB
admet-2414	418	24	beta	beta	NOUN
admet-2414	418	25	.	.	PUNCT
admet-2414	419	1	mol	mol	ADP
admet-2414	419	2	cell	cell	NOUN
admet-2414	419	3	biol	biol	NOUN
admet-2414	419	4	29	29	NUM
admet-2414	419	5	(	(	PUNCT
admet-2414	419	6	2009	2009	NUM
admet-2414	419	7	)	)	PUNCT
admet-2414	419	8	4788	4788	NUM
admet-2414	419	9	-	-	SYM
admet-2414	419	10	4797	4797	NUM
admet-2414	419	11	.	.	PUNCT
admet-2414	420	1	https://doi.org/10.1128/mcb.00649-09	https://doi.org/10.1128/mcb.00649-09	PROPN
admet-2414	420	2	.	.	PUNCT
admet-2414	421	1	[	[	X
admet-2414	421	2	23	23	NUM
admet-2414	421	3	]	]	X
admet-2414	421	4	m.d	m.d	PROPN
admet-2414	421	5	.	.	PROPN
admet-2414	421	6	galigniana	galigniana	PROPN
admet-2414	421	7	,	,	PUNCT
admet-2414	421	8	p.r	p.r	PROPN
admet-2414	421	9	.	.	PROPN
admet-2414	421	10	housley	housley	PROPN
admet-2414	421	11	,	,	PUNCT
admet-2414	421	12	d.b	d.b	PROPN
admet-2414	421	13	.	.	PROPN
admet-2414	421	14	defranco	defranco	PROPN
admet-2414	421	15	,	,	PUNCT
admet-2414	421	16	w.b	w.b	PROPN
admet-2414	421	17	.	.	PUNCT
admet-2414	421	18	pratt	pratt	PROPN
admet-2414	421	19	.	.	PUNCT
admet-2414	422	1	inhibition	inhibition	NOUN
admet-2414	422	2	of	of	ADP
admet-2414	422	3	glucocorticoid	glucocorticoid	ADJ
admet-2414	422	4	receptor	receptor	NOUN
admet-2414	422	5	nucleocytoplasmic	nucleocytoplasmic	ADJ
admet-2414	422	6	shuttling	shuttling	NOUN
admet-2414	422	7	by	by	ADP
admet-2414	422	8	okadaic	okadaic	ADJ
admet-2414	422	9	acid	acid	PROPN
admet-2414	422	10	requires	require	VERB
admet-2414	422	11	intact	intact	ADJ
admet-2414	422	12	cytoskeleton	cytoskeleton	NOUN
admet-2414	422	13	.	.	PUNCT
admet-2414	423	1	j	j	PROPN
admet-2414	423	2	biol	biol	PROPN
admet-2414	423	3	chem	chem	NOUN
admet-2414	423	4	274	274	NUM
admet-2414	423	5	(	(	PUNCT
admet-2414	423	6	1999	1999	NUM
admet-2414	423	7	)	)	PUNCT
admet-2414	423	8	16222	16222	NUM
admet-2414	423	9	-	-	SYM
admet-2414	423	10	16227	16227	NUM
admet-2414	423	11	.	.	PUNCT
admet-2414	424	1	https://doi.org/10.1074/jbc.274.23.16222	https://doi.org/10.1074/jbc.274.23.16222	PROPN
admet-2414	424	2	.	.	PUNCT
admet-2414	425	1	[	[	X
admet-2414	425	2	24	24	NUM
admet-2414	425	3	]	]	SYM
admet-2414	425	4	f.n	f.n	PROPN
admet-2414	425	5	.	.	PROPN
admet-2414	425	6	sackey	sackey	PROPN
admet-2414	425	7	,	,	PUNCT
admet-2414	425	8	r.j	r.j	PROPN
admet-2414	425	9	.	.	PROPN
admet-2414	425	10	hache	hache	PROPN
admet-2414	425	11	,	,	PUNCT
admet-2414	425	12	t.	t.	PROPN
admet-2414	425	13	reich	reich	PROPN
admet-2414	425	14	,	,	PUNCT
admet-2414	425	15	j.	j.	PROPN
admet-2414	425	16	kwast	kwast	PROPN
admet-2414	425	17	-	-	PUNCT
admet-2414	425	18	welfeld	welfeld	NOUN
admet-2414	425	19	,	,	PUNCT
admet-2414	425	20	y.a	y.a	PROPN
admet-2414	425	21	.	.	PROPN
admet-2414	425	22	lefebvre	lefebvre	PROPN
admet-2414	425	23	.	.	PUNCT
admet-2414	426	1	determinants	determinant	NOUN
admet-2414	426	2	of	of	ADP
admet-2414	426	3	subcellular	subcellular	ADJ
admet-2414	426	4	distribution	distribution	NOUN
admet-2414	426	5	of	of	ADP
admet-2414	426	6	the	the	DET
admet-2414	426	7	glucocorticoid	glucocorticoid	ADJ
admet-2414	426	8	receptor	receptor	NOUN
admet-2414	426	9	.	.	PUNCT
admet-2414	427	1	mol	mol	ADP
admet-2414	427	2	endocrinol	endocrinol	NOUN
admet-2414	427	3	10	10	NUM
admet-2414	427	4	(	(	PUNCT
admet-2414	427	5	1996	1996	NUM
admet-2414	427	6	)	)	PUNCT
admet-2414	427	7	1191	1191	NUM
admet-2414	427	8	-	-	SYM
admet-2414	427	9	1205	1205	NUM
admet-2414	427	10	.	.	PUNCT
admet-2414	428	1	https://doi.org/10.1210/mend.10.10.9121487	https://doi.org/10.1210/mend.10.10.9121487	PROPN
admet-2414	428	2	.	.	PUNCT
admet-2414	429	1	[	[	X
admet-2414	429	2	25	25	NUM
admet-2414	429	3	]	]	X
admet-2414	429	4	l.	l.	PROPN
admet-2414	429	5	mercier	mercier	PROPN
admet-2414	429	6	,	,	PUNCT
admet-2414	429	7	e.b	e.b	PROPN
admet-2414	429	8	.	.	PROPN
admet-2414	429	9	thompson	thompson	PROPN
admet-2414	429	10	,	,	PUNCT
admet-2414	429	11	s.s	s.s	PROPN
admet-2414	429	12	.	.	PROPN
admet-2414	429	13	simons	simons	PROPN
admet-2414	429	14	,	,	PUNCT
admet-2414	429	15	jr	jr	PROPN
admet-2414	429	16	.	.	PROPN
admet-2414	429	17	dissociation	dissociation	NOUN
admet-2414	429	18	of	of	ADP
admet-2414	429	19	steroid	steroid	NOUN
admet-2414	429	20	binding	binding	NOUN
admet-2414	429	21	to	to	ADP
admet-2414	429	22	receptors	receptor	NOUN
admet-2414	429	23	and	and	CCONJ
admet-2414	429	24	steroid	steroid	NOUN
admet-2414	429	25	induction	induction	NOUN
admet-2414	429	26	of	of	ADP
admet-2414	429	27	biological	biological	ADJ
admet-2414	429	28	activity	activity	NOUN
admet-2414	429	29	in	in	ADP
admet-2414	429	30	a	a	DET
admet-2414	429	31	glucocorticoid	glucocorticoid	ADJ
admet-2414	429	32	-	-	PUNCT
admet-2414	429	33	responsive	responsive	ADJ
admet-2414	429	34	cell	cell	NOUN
admet-2414	429	35	.	.	PUNCT
admet-2414	430	1	endocrinology	endocrinology	NOUN
admet-2414	430	2	112	112	NUM
admet-2414	430	3	(	(	PUNCT
admet-2414	430	4	1983	1983	NUM
admet-2414	430	5	)	)	PUNCT
admet-2414	430	6	601609	601609	NUM
admet-2414	430	7	.	.	PUNCT
admet-2414	431	1	https://doi.org/10.1210/endo-112-2-601	https://doi.org/10.1210/endo-112-2-601	X
admet-2414	431	2	.	.	PUNCT
admet-2414	432	1	[	[	X
admet-2414	432	2	26	26	NUM
admet-2414	432	3	]	]	X
admet-2414	432	4	r.	r.	PROPN
admet-2414	432	5	rupprecht	rupprecht	PROPN
admet-2414	432	6	,	,	PUNCT
admet-2414	432	7	j.m	j.m	PROPN
admet-2414	432	8	.	.	PROPN
admet-2414	432	9	reul	reul	PROPN
admet-2414	432	10	,	,	PUNCT
admet-2414	432	11	b.	b.	PROPN
admet-2414	432	12	van	van	PROPN
admet-2414	432	13	steensel	steensel	PROPN
admet-2414	432	14	,	,	PUNCT
admet-2414	432	15	d.	d.	PROPN
admet-2414	432	16	spengler	spengler	PROPN
admet-2414	432	17	,	,	PUNCT
admet-2414	432	18	m.	m.	NOUN
admet-2414	432	19	soder	soder	NOUN
admet-2414	432	20	,	,	PUNCT
admet-2414	432	21	b.	b.	PROPN
admet-2414	432	22	berning	berning	PROPN
admet-2414	432	23	,	,	PUNCT
admet-2414	432	24	f.	f.	PROPN
admet-2414	432	25	holsboer	holsboer	PROPN
admet-2414	432	26	,	,	PUNCT
admet-2414	432	27	k.	k.	PROPN
admet-2414	432	28	damm	damm	PROPN
admet-2414	432	29	.	.	PUNCT
admet-2414	433	1	pharmacological	pharmacological	ADJ
admet-2414	433	2	and	and	CCONJ
admet-2414	433	3	functional	functional	ADJ
admet-2414	433	4	characterization	characterization	NOUN
admet-2414	433	5	of	of	ADP
admet-2414	433	6	human	human	ADJ
admet-2414	433	7	mineralocorticoid	mineralocorticoid	NOUN
admet-2414	433	8	and	and	CCONJ
admet-2414	433	9	glucocorticoid	glucocorticoid	ADJ
admet-2414	433	10	receptor	receptor	NOUN
admet-2414	433	11	ligands	ligand	NOUN
admet-2414	433	12	.	.	PUNCT
admet-2414	434	1	eur	eur	PROPN
admet-2414	434	2	j	j	PROPN
admet-2414	434	3	pharmacol	pharmacol	PROPN
admet-2414	434	4	247	247	NUM
admet-2414	434	5	(	(	PUNCT
admet-2414	434	6	1993	1993	NUM
admet-2414	434	7	)	)	PUNCT
admet-2414	434	8	145	145	NUM
admet-2414	434	9	-	-	SYM
admet-2414	434	10	154	154	NUM
admet-2414	434	11	.	.	PUNCT
admet-2414	434	12	https://doi.org/10.1016/09224106(93)90072-h	https://doi.org/10.1016/09224106(93)90072-h	PROPN
admet-2414	434	13	.	.	PUNCT
admet-2414	435	1	[	[	X
admet-2414	435	2	27	27	NUM
admet-2414	435	3	]	]	PUNCT
admet-2414	435	4	a.	a.	NOUN
admet-2414	435	5	munck	munck	PROPN
admet-2414	435	6	,	,	PUNCT
admet-2414	435	7	r.	r.	PROPN
admet-2414	435	8	foley	foley	PROPN
admet-2414	435	9	.	.	PUNCT
admet-2414	436	1	kinetics	kinetic	NOUN
admet-2414	436	2	of	of	ADP
admet-2414	436	3	glucocorticoid	glucocorticoid	ADJ
admet-2414	436	4	-	-	PUNCT
admet-2414	436	5	receptor	receptor	NOUN
admet-2414	436	6	complexes	complex	NOUN
admet-2414	436	7	in	in	ADP
admet-2414	436	8	rat	rat	NOUN
admet-2414	436	9	thymus	thymus	ADJ
admet-2414	436	10	cells	cell	NOUN
admet-2414	436	11	.	.	PUNCT
admet-2414	437	1	j	j	PROPN
admet-2414	437	2	steroid	steroid	PROPN
admet-2414	437	3	biochem	biochem	PROPN
admet-2414	437	4	7	7	NUM
admet-2414	437	5	(	(	PUNCT
admet-2414	437	6	1976	1976	NUM
admet-2414	437	7	)	)	PUNCT
admet-2414	437	8	1117	1117	NUM
admet-2414	437	9	-	-	SYM
admet-2414	437	10	1122	1122	NUM
admet-2414	437	11	.	.	PUNCT
admet-2414	438	1	https://doi.org/10.1016/0022-4731(76)90042-x	https://doi.org/10.1016/0022-4731(76)90042-x	AUX
admet-2414	438	2	.	.	PUNCT
admet-2414	438	3	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	438	4	https://doi.org/10.1056/nejm198712173172504	https://doi.org/10.1056/nejm198712173172504	VERB
admet-2414	438	5	https://doi.org/10.1016/j.jaad.2016.01.062	https://doi.org/10.1016/j.jaad.2016.01.062	PRON
admet-2414	438	6	https://doi.org/10.1097/00000658-197609000-00011	https://doi.org/10.1097/00000658-197609000-00011	PRON
admet-2414	438	7	https://doi.org/10.1210/en.2016-1123	https://doi.org/10.1210/en.2016-1123	VERB
admet-2414	438	8	https://doi.org/10.1016/j.mce.2023.111884	https://doi.org/10.1016/j.mce.2023.111884	PRON
admet-2414	439	1	https://doi.org/10.1128/mcb.01570-06	https://doi.org/10.1128/mcb.01570-06	PROPN
admet-2414	439	2	https://doi.org/10.1083/jcb.137.3.523	https://doi.org/10.1083/jcb.137.3.523	NOUN
admet-2414	439	3	https://doi.org/10.1074/jbc.274.3.1432	https://doi.org/10.1074/jbc.274.3.1432	NUM
admet-2414	439	4	https://doi.org/10.1080/15287397809529668	https://doi.org/10.1080/15287397809529668	NOUN
admet-2414	439	5	https://doi.org/10.1073/pnas.93.10.4845	https://doi.org/10.1073/pnas.93.10.4845	PROPN
admet-2414	439	6	https://doi.org/10.1128/mcb.00649-09	https://doi.org/10.1128/mcb.00649-09	PROPN
admet-2414	439	7	https://doi.org/10.1074/jbc.274.23.16222	https://doi.org/10.1074/jbc.274.23.16222	PROPN
admet-2414	439	8	https://doi.org/10.1210/mend.10.10.9121487	https://doi.org/10.1210/mend.10.10.9121487	PROPN
admet-2414	439	9	https://doi.org/10.1210/endo-112-2-601	https://doi.org/10.1210/endo-112-2-601	PROPN
admet-2414	439	10	https://doi.org/10.1016/0922-4106(93)90072-h	https://doi.org/10.1016/0922-4106(93)90072-h	PROPN
admet-2414	440	1	https://doi.org/10.1016/0922-4106(93)90072-h	https://doi.org/10.1016/0922-4106(93)90072-h	PROPN
admet-2414	440	2	https://doi.org/10.1016/0022-4731(76)90042-x	https://doi.org/10.1016/0022-4731(76)90042-x	PROPN
admet-2414	440	3	d.	d.	PROPN
admet-2414	440	4	g.	g.	PROPN
admet-2414	440	5	levitt	levitt	PROPN
admet-2414	440	6	admet	admet	PROPN
admet-2414	440	7	&	&	CCONJ
admet-2414	440	8	dmpk	dmpk	PROPN
admet-2414	440	9	12(6	12(6	NUM
admet-2414	440	10	)	)	PUNCT
admet-2414	440	11	(	(	PUNCT
admet-2414	440	12	2024	2024	NUM
admet-2414	440	13	)	)	PUNCT
admet-2414	440	14	971	971	NUM
admet-2414	440	15	-	-	SYM
admet-2414	440	16	989	989	NUM
admet-2414	440	17	988	988	NUM
admet-2414	440	18	[	[	X
admet-2414	440	19	28	28	NUM
admet-2414	440	20	]	]	PUNCT
admet-2414	440	21	k.	k.	PROPN
admet-2414	440	22	ishikawa	ishikawa	PROPN
admet-2414	440	23	,	,	PUNCT
admet-2414	440	24	s.	s.	PROPN
admet-2414	440	25	tamamura	tamamura	PROPN
admet-2414	440	26	,	,	PUNCT
admet-2414	440	27	k.	k.	PROPN
admet-2414	440	28	semba	semba	PROPN
admet-2414	440	29	,	,	PUNCT
admet-2414	440	30	s.	s.	PROPN
admet-2414	440	31	watanabe	watanabe	PROPN
admet-2414	440	32	.	.	PUNCT
admet-2414	440	33	establishment	establishment	NOUN
admet-2414	440	34	of	of	ADP
admet-2414	440	35	reporter	reporter	NOUN
admet-2414	440	36	cells	cell	NOUN
admet-2414	440	37	that	that	PRON
admet-2414	440	38	respond	respond	VERB
admet-2414	440	39	to	to	ADP
admet-2414	440	40	glucocorticoids	glucocorticoid	NOUN
admet-2414	440	41	by	by	ADP
admet-2414	440	42	a	a	DET
admet-2414	440	43	transposon	transposon	NOUN
admet-2414	440	44	-	-	PUNCT
admet-2414	440	45	mediated	mediate	VERB
admet-2414	440	46	promoter	promoter	NOUN
admet-2414	440	47	-	-	PUNCT
admet-2414	440	48	trapping	trap	VERB
admet-2414	440	49	system	system	NOUN
admet-2414	440	50	.	.	PUNCT
admet-2414	441	1	eur	eur	PROPN
admet-2414	441	2	j	j	PROPN
admet-2414	441	3	pharm	pharm	PROPN
admet-2414	441	4	sci	sci	PROPN
admet-2414	441	5	162	162	NUM
admet-2414	441	6	(	(	PUNCT
admet-2414	441	7	2021	2021	NUM
admet-2414	441	8	)	)	PUNCT
admet-2414	441	9	105819	105819	NUM
admet-2414	441	10	.	.	PUNCT
admet-2414	442	1	https://doi.org/10.1016/j.ejps.2021.105819	https://doi.org/10.1016/j.ejps.2021.105819	NOUN
admet-2414	442	2	.	.	PUNCT
admet-2414	443	1	[	[	X
admet-2414	443	2	29	29	NUM
admet-2414	443	3	]	]	X
admet-2414	443	4	b.m	b.m	PROPN
admet-2414	443	5	.	.	PROPN
admet-2414	443	6	necela	necela	PROPN
admet-2414	443	7	,	,	PUNCT
admet-2414	443	8	j.a	j.a	PROPN
admet-2414	443	9	.	.	PROPN
admet-2414	443	10	cidlowski	cidlowski	PROPN
admet-2414	443	11	.	.	PUNCT
admet-2414	444	1	development	development	NOUN
admet-2414	444	2	of	of	ADP
admet-2414	444	3	a	a	DET
admet-2414	444	4	flow	flow	NOUN
admet-2414	444	5	cytometric	cytometric	ADJ
admet-2414	444	6	assay	assay	NOUN
admet-2414	444	7	to	to	PART
admet-2414	444	8	study	study	VERB
admet-2414	444	9	glucocorticoid	glucocorticoid	ADJ
admet-2414	444	10	receptor	receptor	NOUN
admet-2414	444	11	-	-	PUNCT
admet-2414	444	12	mediated	mediate	VERB
admet-2414	444	13	gene	gene	NOUN
admet-2414	444	14	activation	activation	NOUN
admet-2414	444	15	in	in	ADP
admet-2414	444	16	living	living	NOUN
admet-2414	444	17	cells	cell	NOUN
admet-2414	444	18	.	.	PUNCT
admet-2414	445	1	steroids	steroid	NOUN
admet-2414	445	2	68	68	NUM
admet-2414	445	3	(	(	PUNCT
admet-2414	445	4	2003	2003	NUM
admet-2414	445	5	)	)	PUNCT
admet-2414	445	6	341	341	NUM
admet-2414	445	7	-	-	SYM
admet-2414	445	8	350	350	NUM
admet-2414	445	9	.	.	PUNCT
admet-2414	446	1	https://doi.org/10.1016/s0039-128x(03)00032-1	https://doi.org/10.1016/s0039-128x(03)00032-1	ADJ
admet-2414	446	2	.	.	PUNCT
admet-2414	447	1	[	[	X
admet-2414	447	2	30	30	NUM
admet-2414	447	3	]	]	PUNCT
admet-2414	447	4	a.	a.	NOUN
admet-2414	447	5	novotna	novotna	PROPN
admet-2414	447	6	,	,	PUNCT
admet-2414	447	7	p.	p.	NOUN
admet-2414	447	8	pavek	pavek	NOUN
admet-2414	447	9	,	,	PUNCT
admet-2414	447	10	z.	z.	PROPN
admet-2414	447	11	dvorak	dvorak	PROPN
admet-2414	447	12	.	.	PUNCT
admet-2414	448	1	construction	construction	NOUN
admet-2414	448	2	and	and	CCONJ
admet-2414	448	3	characterization	characterization	NOUN
admet-2414	448	4	of	of	ADP
admet-2414	448	5	a	a	DET
admet-2414	448	6	reporter	reporter	NOUN
admet-2414	448	7	gene	gene	NOUN
admet-2414	448	8	cell	cell	NOUN
admet-2414	448	9	line	line	NOUN
admet-2414	448	10	for	for	ADP
admet-2414	448	11	assessment	assessment	NOUN
admet-2414	448	12	of	of	ADP
admet-2414	448	13	human	human	ADJ
admet-2414	448	14	glucocorticoid	glucocorticoid	ADJ
admet-2414	448	15	receptor	receptor	NOUN
admet-2414	448	16	activation	activation	NOUN
admet-2414	448	17	.	.	PUNCT
admet-2414	449	1	eur	eur	PROPN
admet-2414	449	2	j	j	PROPN
admet-2414	449	3	pharm	pharm	PROPN
admet-2414	449	4	sci	sci	PROPN
admet-2414	449	5	47	47	NUM
admet-2414	449	6	(	(	PUNCT
admet-2414	449	7	2012	2012	NUM
admet-2414	449	8	)	)	PUNCT
admet-2414	449	9	842	842	NUM
admet-2414	449	10	-	-	SYM
admet-2414	449	11	847	847	NUM
admet-2414	449	12	.	.	PUNCT
admet-2414	450	1	https://doi.org/10.1016/j.ejps.2012.10.003	https://doi.org/10.1016/j.ejps.2012.10.003	NOUN
admet-2414	450	2	.	.	PUNCT
admet-2414	451	1	[	[	X
admet-2414	451	2	31	31	NUM
admet-2414	451	3	]	]	PUNCT
admet-2414	451	4	l.	l.	PROPN
admet-2414	451	5	van	van	PROPN
admet-2414	451	6	moortel	moortel	PROPN
admet-2414	451	7	,	,	PUNCT
admet-2414	451	8	j.	j.	PROPN
admet-2414	451	9	thommis	thommis	PROPN
admet-2414	451	10	,	,	PUNCT
admet-2414	451	11	b.	b.	PROPN
admet-2414	451	12	maertens	maertens	PROPN
admet-2414	451	13	,	,	PUNCT
admet-2414	451	14	a.	a.	NOUN
admet-2414	451	15	staes	staes	NOUN
admet-2414	451	16	,	,	PUNCT
admet-2414	451	17	d.	d.	PROPN
admet-2414	451	18	clarisse	clarisse	PROPN
admet-2414	451	19	,	,	PUNCT
admet-2414	451	20	d.	d.	PROPN
admet-2414	451	21	de	de	PROPN
admet-2414	451	22	sutter	sutter	PROPN
admet-2414	451	23	,	,	PUNCT
admet-2414	451	24	c.	c.	PROPN
admet-2414	451	25	libert	libert	PROPN
admet-2414	451	26	,	,	PUNCT
admet-2414	451	27	o.c	o.c	PROPN
admet-2414	451	28	.	.	PROPN
admet-2414	451	29	meijer	meijer	PROPN
admet-2414	451	30	,	,	PUNCT
admet-2414	451	31	s.	s.	PROPN
admet-2414	451	32	eyckerman	eyckerman	PROPN
admet-2414	451	33	,	,	PUNCT
admet-2414	451	34	k.	k.	PROPN
admet-2414	451	35	gevaert	gevaert	PROPN
admet-2414	451	36	,	,	PUNCT
admet-2414	451	37	k.	k.	PROPN
admet-2414	451	38	de	de	PROPN
admet-2414	451	39	bosscher	bosscher	PROPN
admet-2414	451	40	.	.	PUNCT
admet-2414	452	1	novel	novel	ADJ
admet-2414	452	2	assays	assay	NOUN
admet-2414	452	3	monitoring	monitor	VERB
admet-2414	452	4	direct	direct	ADJ
admet-2414	452	5	glucocorticoid	glucocorticoid	ADJ
admet-2414	452	6	receptor	receptor	NOUN
admet-2414	452	7	protein	protein	NOUN
admet-2414	452	8	activity	activity	NOUN
admet-2414	452	9	exhibit	exhibit	VERB
admet-2414	452	10	high	high	ADJ
admet-2414	452	11	predictive	predictive	ADJ
admet-2414	452	12	power	power	NOUN
admet-2414	452	13	for	for	ADP
admet-2414	452	14	ligand	ligand	ADJ
admet-2414	452	15	activity	activity	NOUN
admet-2414	452	16	on	on	ADP
admet-2414	452	17	endogenous	endogenous	ADJ
admet-2414	452	18	gene	gene	NOUN
admet-2414	452	19	targets	target	NOUN
admet-2414	452	20	.	.	PUNCT
admet-2414	453	1	biomed	biome	VERB
admet-2414	453	2	pharmacother	pharmacother	ADJ
admet-2414	453	3	152	152	NUM
admet-2414	453	4	(	(	PUNCT
admet-2414	453	5	2022	2022	NUM
admet-2414	453	6	)	)	PUNCT
admet-2414	453	7	113218	113218	NUM
admet-2414	453	8	.	.	PUNCT
admet-2414	454	1	https://doi.org/10.1016/j.biopha.2022.113218	https://doi.org/10.1016/j.biopha.2022.113218	NOUN
admet-2414	454	2	.	.	PUNCT
admet-2414	455	1	[	[	X
admet-2414	455	2	32	32	NUM
admet-2414	455	3	]	]	PUNCT
admet-2414	455	4	h.	h.	NOUN
admet-2414	455	5	russcher	russcher	NOUN
admet-2414	455	6	,	,	PUNCT
admet-2414	455	7	p.	p.	PROPN
admet-2414	455	8	smit	smit	PROPN
admet-2414	455	9	,	,	PUNCT
admet-2414	455	10	e.l	e.l	PROPN
admet-2414	455	11	.	.	PROPN
admet-2414	455	12	van	van	PROPN
admet-2414	455	13	den	den	PROPN
admet-2414	455	14	akker	akker	PROPN
admet-2414	455	15	,	,	PUNCT
admet-2414	455	16	e.f	e.f	PROPN
admet-2414	455	17	.	.	PROPN
admet-2414	455	18	van	van	PROPN
admet-2414	455	19	rossum	rossum	PROPN
admet-2414	455	20	,	,	PUNCT
admet-2414	455	21	a.o	a.o	PROPN
admet-2414	455	22	.	.	PROPN
admet-2414	455	23	brinkmann	brinkmann	PROPN
admet-2414	455	24	,	,	PUNCT
admet-2414	455	25	f.h	f.h	PROPN
admet-2414	455	26	.	.	PROPN
admet-2414	455	27	de	de	PROPN
admet-2414	455	28	jong	jong	PROPN
admet-2414	455	29	,	,	PUNCT
admet-2414	455	30	s.w	s.w	PROPN
admet-2414	455	31	.	.	PROPN
admet-2414	455	32	lamberts	lamberts	PROPN
admet-2414	455	33	,	,	PUNCT
admet-2414	455	34	j.w	j.w	PROPN
admet-2414	455	35	.	.	PROPN
admet-2414	455	36	koper	koper	PROPN
admet-2414	455	37	.	.	PUNCT
admet-2414	456	1	two	two	NUM
admet-2414	456	2	polymorphisms	polymorphism	NOUN
admet-2414	456	3	in	in	ADP
admet-2414	456	4	the	the	DET
admet-2414	456	5	glucocorticoid	glucocorticoid	ADJ
admet-2414	456	6	receptor	receptor	NOUN
admet-2414	456	7	gene	gene	NOUN
admet-2414	456	8	directly	directly	ADV
admet-2414	456	9	affect	affect	VERB
admet-2414	456	10	glucocorticoid	glucocorticoid	NOUN
admet-2414	456	11	-	-	PUNCT
admet-2414	456	12	regulated	regulate	VERB
admet-2414	456	13	gene	gene	NOUN
admet-2414	456	14	expression	expression	NOUN
admet-2414	456	15	.	.	PUNCT
admet-2414	457	1	j	j	PROPN
admet-2414	457	2	clin	clin	PROPN
admet-2414	457	3	endocrinol	endocrinol	PROPN
admet-2414	457	4	metab	metab	NOUN
admet-2414	457	5	90	90	NUM
admet-2414	457	6	(	(	PUNCT
admet-2414	457	7	2005	2005	NUM
admet-2414	457	8	)	)	PUNCT
admet-2414	457	9	5804	5804	NUM
admet-2414	457	10	-	-	SYM
admet-2414	457	11	5810	5810	NUM
admet-2414	457	12	.	.	PUNCT
admet-2414	458	1	https://doi.org/10.1210/jc.2005-0646	https://doi.org/10.1210/jc.2005-0646	PROPN
admet-2414	458	2	.	.	PUNCT
admet-2414	459	1	[	[	X
admet-2414	459	2	33	33	NUM
admet-2414	459	3	]	]	PUNCT
admet-2414	459	4	s.	s.	PROPN
admet-2414	459	5	rosewicz	rosewicz	PROPN
admet-2414	459	6	,	,	PUNCT
admet-2414	459	7	c.d	c.d	PROPN
admet-2414	459	8	.	.	PROPN
admet-2414	459	9	logsdon	logsdon	PROPN
admet-2414	459	10	.	.	PUNCT
admet-2414	460	1	glucocorticoids	glucocorticoid	NOUN
admet-2414	460	2	stimulate	stimulate	VERB
admet-2414	460	3	ornithine	ornithine	NOUN
admet-2414	460	4	decarboxylase	decarboxylase	NOUN
admet-2414	460	5	gene	gene	NOUN
admet-2414	460	6	expression	expression	NOUN
admet-2414	460	7	in	in	ADP
admet-2414	460	8	pancreatic	pancreatic	ADJ
admet-2414	460	9	ar42j	ar42j	NOUN
admet-2414	460	10	cells	cell	NOUN
admet-2414	460	11	.	.	PUNCT
admet-2414	461	1	gastroenterology	gastroenterology	NOUN
admet-2414	461	2	101	101	NUM
admet-2414	461	3	(	(	PUNCT
admet-2414	461	4	1991	1991	NUM
admet-2414	461	5	)	)	PUNCT
admet-2414	461	6	1102	1102	NUM
admet-2414	461	7	-	-	SYM
admet-2414	461	8	1108	1108	NUM
admet-2414	461	9	.	.	PUNCT
admet-2414	462	1	https://doi.org/10.1016/00165085(91)90740-c	https://doi.org/10.1016/00165085(91)90740-c	PROPN
admet-2414	462	2	.	.	PUNCT
admet-2414	463	1	[	[	X
admet-2414	463	2	34	34	NUM
admet-2414	463	3	]	]	X
admet-2414	463	4	g.	g.	PROPN
admet-2414	463	5	otulakowski	otulakowski	PROPN
admet-2414	463	6	,	,	PUNCT
admet-2414	463	7	w.	w.	PROPN
admet-2414	463	8	duan	duan	PROPN
admet-2414	463	9	,	,	PUNCT
admet-2414	463	10	a.	a.	NOUN
admet-2414	463	11	sarangapani	sarangapani	PROPN
admet-2414	463	12	,	,	PUNCT
admet-2414	463	13	s.	s.	PROPN
admet-2414	463	14	gandhi	gandhi	PROPN
admet-2414	463	15	,	,	PUNCT
admet-2414	463	16	h.	h.	PROPN
admet-2414	463	17	o'brodovich	o'brodovich	PROPN
admet-2414	463	18	.	.	PUNCT
admet-2414	464	1	glucocorticoid	glucocorticoid	NOUN
admet-2414	464	2	-	-	PUNCT
admet-2414	464	3	mediated	mediate	VERB
admet-2414	464	4	repression	repression	NOUN
admet-2414	464	5	of	of	ADP
admet-2414	464	6	redd1	redd1	NOUN
admet-2414	464	7	mrna	mrna	NOUN
admet-2414	464	8	expression	expression	NOUN
admet-2414	464	9	in	in	ADP
admet-2414	464	10	rat	rat	ADJ
admet-2414	464	11	fetal	fetal	ADJ
admet-2414	464	12	distal	distal	ADJ
admet-2414	464	13	lung	lung	NOUN
admet-2414	464	14	epithelial	epithelial	ADJ
admet-2414	464	15	cells	cell	NOUN
admet-2414	464	16	.	.	PUNCT
admet-2414	465	1	pediatr	pediatr	ADJ
admet-2414	465	2	res	re	NOUN
admet-2414	465	3	65	65	NUM
admet-2414	465	4	(	(	PUNCT
admet-2414	465	5	2009	2009	NUM
admet-2414	465	6	)	)	PUNCT
admet-2414	465	7	514	514	NUM
admet-2414	465	8	-	-	SYM
admet-2414	465	9	519	519	NUM
admet-2414	465	10	.	.	PUNCT
admet-2414	466	1	https://doi.org/10.1203/pdr.0b013e3181998db6	https://doi.org/10.1203/pdr.0b013e3181998db6	X
admet-2414	466	2	.	.	PUNCT
admet-2414	467	1	[	[	X
admet-2414	467	2	35	35	NUM
admet-2414	467	3	]	]	X
admet-2414	467	4	c.j	c.j	PROPN
admet-2414	467	5	.	.	PROPN
admet-2414	467	6	hupfeld	hupfeld	PROPN
admet-2414	467	7	,	,	PUNCT
admet-2414	467	8	j.a	j.a	PROPN
admet-2414	467	9	.	.	PROPN
admet-2414	467	10	iniguez	iniguez	PROPN
admet-2414	467	11	-	-	PUNCT
admet-2414	467	12	lluhi	lluhi	ADJ
admet-2414	467	13	,	,	PUNCT
admet-2414	467	14	adrenocorticotropic	adrenocorticotropic	NOUN
admet-2414	467	15	hormone	hormone	NOUN
admet-2414	467	16	,	,	PUNCT
admet-2414	467	17	adrenal	adrenal	ADJ
admet-2414	467	18	steroids	steroid	NOUN
admet-2414	467	19	,	,	PUNCT
admet-2414	467	20	and	and	CCONJ
admet-2414	467	21	the	the	DET
admet-2414	467	22	adrenal	adrenal	ADJ
admet-2414	467	23	cortex	cortex	NOUN
admet-2414	467	24	in	in	ADP
admet-2414	467	25	goodman	goodman	PROPN
admet-2414	467	26	&	&	CCONJ
admet-2414	467	27	gilman	gilman	PROPN
admet-2414	467	28	's	's	PART
admet-2414	467	29	:	:	PUNCT
admet-2414	467	30	the	the	DET
admet-2414	467	31	pharmacological	pharmacological	ADJ
admet-2414	467	32	basis	basis	NOUN
admet-2414	467	33	of	of	ADP
admet-2414	467	34	therapeutics	therapeutic	NOUN
admet-2414	467	35	,	,	PUNCT
admet-2414	467	36	l.l	l.l	PROPN
admet-2414	467	37	.	.	PROPN
admet-2414	467	38	brunton	brunton	PROPN
admet-2414	467	39	,	,	PUNCT
admet-2414	467	40	b.c	b.c	PROPN
admet-2414	467	41	.	.	PROPN
admet-2414	467	42	knollman	knollman	PROPN
admet-2414	467	43	(	(	PUNCT
admet-2414	467	44	eds	ed	NOUN
admet-2414	467	45	.	.	PUNCT
admet-2414	467	46	)	)	PUNCT
admet-2414	467	47	,	,	PUNCT
admet-2414	467	48	mcgraw	mcgraw	PROPN
admet-2414	467	49	hill	hill	PROPN
admet-2414	467	50	,	,	PUNCT
admet-2414	467	51	new	new	PROPN
admet-2414	467	52	york	york	PROPN
admet-2414	467	53	,	,	PUNCT
admet-2414	467	54	2022	2022	NUM
admet-2414	467	55	.	.	PUNCT
admet-2414	468	1	[	[	X
admet-2414	468	2	36	36	NUM
admet-2414	468	3	]	]	X
admet-2414	468	4	d.	d.	PROPN
admet-2414	468	5	jaffuel	jaffuel	PROPN
admet-2414	468	6	,	,	PUNCT
admet-2414	468	7	c.	c.	PROPN
admet-2414	468	8	roumestan	roumestan	PROPN
admet-2414	468	9	,	,	PUNCT
admet-2414	468	10	p.	p.	PROPN
admet-2414	468	11	balaguer	balaguer	PROPN
admet-2414	468	12	,	,	PUNCT
admet-2414	468	13	c.	c.	PROPN
admet-2414	468	14	henriquet	henriquet	PROPN
admet-2414	468	15	,	,	PUNCT
admet-2414	468	16	c.	c.	PROPN
admet-2414	468	17	gougat	gougat	PROPN
admet-2414	468	18	,	,	PUNCT
admet-2414	468	19	j.	j.	PROPN
admet-2414	468	20	bousquet	bousquet	PROPN
admet-2414	468	21	,	,	PUNCT
admet-2414	468	22	p.	p.	NOUN
admet-2414	468	23	demoly	demoly	NOUN
admet-2414	468	24	,	,	PUNCT
admet-2414	468	25	m.	m.	PROPN
admet-2414	468	26	mathieu	mathieu	PROPN
admet-2414	468	27	.	.	PUNCT
admet-2414	469	1	correlation	correlation	NOUN
admet-2414	469	2	between	between	ADP
admet-2414	469	3	different	different	ADJ
admet-2414	469	4	gene	gene	NOUN
admet-2414	469	5	expression	expression	NOUN
admet-2414	469	6	assays	assay	NOUN
admet-2414	469	7	designed	design	VERB
admet-2414	469	8	to	to	PART
admet-2414	469	9	measure	measure	VERB
admet-2414	469	10	trans	tran	NOUN
admet-2414	469	11	-	-	NOUN
admet-2414	469	12	activation	activation	NOUN
admet-2414	469	13	potencies	potency	NOUN
admet-2414	469	14	of	of	ADP
admet-2414	469	15	systemic	systemic	ADJ
admet-2414	469	16	glucocorticoids	glucocorticoid	NOUN
admet-2414	469	17	.	.	PUNCT
admet-2414	470	1	steroids	steroid	NOUN
admet-2414	470	2	66	66	NUM
admet-2414	470	3	(	(	PUNCT
admet-2414	470	4	2001	2001	NUM
admet-2414	470	5	)	)	PUNCT
admet-2414	470	6	597	597	NUM
admet-2414	470	7	-	-	SYM
admet-2414	470	8	604	604	NUM
admet-2414	470	9	.	.	PUNCT
admet-2414	470	10	https://doi.org/10.1016/s0039128x(00)00235-x	https://doi.org/10.1016/s0039128x(00)00235-x	PROPN
admet-2414	470	11	.	.	PUNCT
admet-2414	471	1	[	[	X
admet-2414	471	2	37	37	NUM
admet-2414	471	3	]	]	X
admet-2414	471	4	j.m	j.m	PROPN
admet-2414	471	5	.	.	PROPN
admet-2414	471	6	wilkinson	wilkinson	PROPN
admet-2414	471	7	,	,	PUNCT
admet-2414	471	8	s.	s.	PROPN
admet-2414	471	9	hayes	hayes	PROPN
admet-2414	471	10	,	,	PUNCT
admet-2414	471	11	d.	d.	PROPN
admet-2414	471	12	thompson	thompson	PROPN
admet-2414	471	13	,	,	PUNCT
admet-2414	471	14	p.	p.	PROPN
admet-2414	471	15	whitney	whitney	PROPN
admet-2414	471	16	,	,	PUNCT
admet-2414	471	17	k.	k.	PROPN
admet-2414	471	18	bi	bi	PROPN
admet-2414	471	19	.	.	PROPN
admet-2414	471	20	compound	compound	NOUN
admet-2414	471	21	profiling	profiling	NOUN
admet-2414	471	22	using	use	VERB
admet-2414	471	23	a	a	DET
admet-2414	471	24	panel	panel	NOUN
admet-2414	471	25	of	of	ADP
admet-2414	471	26	steroid	steroid	NOUN
admet-2414	471	27	hormone	hormone	NOUN
admet-2414	471	28	receptor	receptor	NOUN
admet-2414	471	29	cell	cell	NOUN
admet-2414	471	30	-	-	PUNCT
admet-2414	471	31	based	base	VERB
admet-2414	471	32	assays	assay	NOUN
admet-2414	471	33	.	.	PUNCT
admet-2414	472	1	j	j	PROPN
admet-2414	472	2	biomol	biomol	PROPN
admet-2414	472	3	screen	screen	NOUN
admet-2414	472	4	13	13	NUM
admet-2414	472	5	(	(	PUNCT
admet-2414	472	6	2008	2008	NUM
admet-2414	472	7	)	)	PUNCT
admet-2414	473	1	755	755	NUM
admet-2414	473	2	-	-	SYM
admet-2414	473	3	765	765	NUM
admet-2414	473	4	.	.	PUNCT
admet-2414	474	1	https://doi.org/10.1177/1087057108322155	https://doi.org/10.1177/1087057108322155	X
admet-2414	474	2	.	.	PUNCT
admet-2414	475	1	[	[	X
admet-2414	475	2	38	38	NUM
admet-2414	475	3	]	]	PUNCT
admet-2414	475	4	p.	p.	PROPN
admet-2414	475	5	smit	smit	PROPN
admet-2414	475	6	,	,	PUNCT
admet-2414	475	7	h.	h.	PROPN
admet-2414	475	8	russcher	russcher	PROPN
admet-2414	475	9	,	,	PUNCT
admet-2414	475	10	f.h	f.h	PROPN
admet-2414	475	11	.	.	PROPN
admet-2414	475	12	de	de	PROPN
admet-2414	475	13	jong	jong	PROPN
admet-2414	475	14	,	,	PUNCT
admet-2414	475	15	a.o	a.o	PROPN
admet-2414	475	16	.	.	PROPN
admet-2414	475	17	brinkmann	brinkmann	PROPN
admet-2414	475	18	,	,	PUNCT
admet-2414	475	19	s.w	s.w	PROPN
admet-2414	475	20	.	.	PROPN
admet-2414	475	21	lamberts	lamberts	PROPN
admet-2414	475	22	,	,	PUNCT
admet-2414	475	23	j.w	j.w	PROPN
admet-2414	475	24	.	.	PROPN
admet-2414	475	25	koper	koper	PROPN
admet-2414	475	26	.	.	PUNCT
admet-2414	476	1	differential	differential	ADJ
admet-2414	476	2	regulation	regulation	NOUN
admet-2414	476	3	of	of	ADP
admet-2414	476	4	synthetic	synthetic	ADJ
admet-2414	476	5	glucocorticoids	glucocorticoid	NOUN
admet-2414	476	6	on	on	ADP
admet-2414	476	7	gene	gene	NOUN
admet-2414	476	8	expression	expression	NOUN
admet-2414	476	9	levels	level	NOUN
admet-2414	476	10	of	of	ADP
admet-2414	476	11	glucocorticoid	glucocorticoid	NOUN
admet-2414	476	12	-	-	PUNCT
admet-2414	476	13	induced	induce	VERB
admet-2414	476	14	leucine	leucine	NOUN
admet-2414	476	15	zipper	zipper	NOUN
admet-2414	476	16	and	and	CCONJ
admet-2414	476	17	interleukin-2	interleukin-2	NOUN
admet-2414	476	18	.	.	PUNCT
admet-2414	477	1	j	j	PROPN
admet-2414	477	2	clin	clin	PROPN
admet-2414	477	3	endocrinol	endocrinol	PROPN
admet-2414	477	4	metab	metab	NOUN
admet-2414	477	5	90	90	NUM
admet-2414	477	6	(	(	PUNCT
admet-2414	477	7	2005	2005	NUM
admet-2414	477	8	)	)	PUNCT
admet-2414	477	9	2994	2994	NUM
admet-2414	477	10	-	-	SYM
admet-2414	477	11	3000	3000	NUM
admet-2414	477	12	.	.	PUNCT
admet-2414	478	1	https://doi.org/10.1210/jc.2004-2298	https://doi.org/10.1210/jc.2004-2298	NOUN
admet-2414	478	2	.	.	PUNCT
admet-2414	479	1	[	[	X
admet-2414	479	2	39	39	NUM
admet-2414	479	3	]	]	X
admet-2414	479	4	r.j	r.j	PROPN
admet-2414	479	5	.	.	PROPN
admet-2414	479	6	zitnik	zitnik	PROPN
admet-2414	479	7	,	,	PUNCT
admet-2414	479	8	n.l	n.l	PROPN
admet-2414	479	9	.	.	PROPN
admet-2414	479	10	whiting	whiting	PROPN
admet-2414	479	11	,	,	PUNCT
admet-2414	479	12	j.a	j.a	PROPN
admet-2414	479	13	.	.	PROPN
admet-2414	479	14	elias	elias	PROPN
admet-2414	479	15	.	.	PUNCT
admet-2414	480	1	glucocorticoid	glucocorticoid	ADJ
admet-2414	480	2	inhibition	inhibition	NOUN
admet-2414	480	3	of	of	ADP
admet-2414	480	4	interleukin-1	interleukin-1	NOUN
admet-2414	480	5	-	-	PUNCT
admet-2414	480	6	induced	induce	VERB
admet-2414	480	7	interleukin-6	interleukin-6	NUM
admet-2414	480	8	production	production	NOUN
admet-2414	480	9	by	by	ADP
admet-2414	480	10	human	human	ADJ
admet-2414	480	11	lung	lung	NOUN
admet-2414	480	12	fibroblasts	fibroblast	NOUN
admet-2414	480	13	:	:	PUNCT
admet-2414	480	14	evidence	evidence	NOUN
admet-2414	480	15	for	for	ADP
admet-2414	480	16	transcriptional	transcriptional	NOUN
admet-2414	480	17	and	and	CCONJ
admet-2414	480	18	post	post	ADJ
admet-2414	480	19	-	-	ADJ
admet-2414	480	20	transcriptional	transcriptional	ADJ
admet-2414	480	21	regulatory	regulatory	ADJ
admet-2414	480	22	mechanisms	mechanism	NOUN
admet-2414	480	23	.	.	PUNCT
admet-2414	481	1	am	be	AUX
admet-2414	481	2	j	j	PROPN
admet-2414	481	3	respir	respir	NOUN
admet-2414	481	4	cell	cell	NOUN
admet-2414	481	5	mol	mol	ADP
admet-2414	481	6	biol	biol	PROPN
admet-2414	481	7	10	10	NUM
admet-2414	481	8	(	(	PUNCT
admet-2414	481	9	1994	1994	NUM
admet-2414	481	10	)	)	PUNCT
admet-2414	481	11	643	643	NUM
admet-2414	481	12	-	-	SYM
admet-2414	481	13	650	650	NUM
admet-2414	481	14	.	.	PUNCT
admet-2414	482	1	https://doi.org/10.1165/ajrcmb.10.6.7516173	https://doi.org/10.1165/ajrcmb.10.6.7516173	NOUN
admet-2414	482	2	.	.	PUNCT
admet-2414	483	1	[	[	X
admet-2414	483	2	40	40	NUM
admet-2414	483	3	]	]	PUNCT
admet-2414	483	4	d.	d.	PROPN
admet-2414	483	5	sedlak	sedlak	PROPN
admet-2414	483	6	,	,	PUNCT
admet-2414	483	7	a.	a.	NOUN
admet-2414	483	8	paguio	paguio	NOUN
admet-2414	483	9	,	,	PUNCT
admet-2414	483	10	p.	p.	NOUN
admet-2414	483	11	bartunek	bartunek	NOUN
admet-2414	483	12	.	.	PUNCT
admet-2414	484	1	two	two	NUM
admet-2414	484	2	panels	panel	NOUN
admet-2414	484	3	of	of	ADP
admet-2414	484	4	steroid	steroid	NOUN
admet-2414	484	5	receptor	receptor	NOUN
admet-2414	484	6	luciferase	luciferase	NOUN
admet-2414	484	7	reporter	reporter	NOUN
admet-2414	484	8	cell	cell	NOUN
admet-2414	484	9	lines	line	NOUN
admet-2414	484	10	for	for	ADP
admet-2414	484	11	compound	compound	NOUN
admet-2414	484	12	profiling	profiling	NOUN
admet-2414	484	13	.	.	PUNCT
admet-2414	485	1	comb	comb	NOUN
admet-2414	485	2	chem	chem	NOUN
admet-2414	485	3	high	high	ADJ
admet-2414	485	4	throughput	throughput	NOUN
admet-2414	485	5	screen	screen	NOUN
admet-2414	485	6	14	14	NUM
admet-2414	485	7	(	(	PUNCT
admet-2414	485	8	2011	2011	NUM
admet-2414	485	9	)	)	PUNCT
admet-2414	485	10	248	248	NUM
admet-2414	485	11	-	-	SYM
admet-2414	485	12	266	266	NUM
admet-2414	485	13	.	.	PUNCT
admet-2414	486	1	https://doi.org/10.2174/138620711795222446	https://doi.org/10.2174/138620711795222446	NOUN
admet-2414	486	2	.	.	PUNCT
admet-2414	487	1	[	[	X
admet-2414	487	2	41	41	NUM
admet-2414	487	3	]	]	X
admet-2414	487	4	r.c	r.c	PROPN
admet-2414	487	5	.	.	PROPN
admet-2414	487	6	bhake	bhake	PROPN
admet-2414	487	7	,	,	PUNCT
admet-2414	487	8	v.	v.	CCONJ
admet-2414	487	9	kluckner	kluckner	PROPN
admet-2414	487	10	,	,	PUNCT
admet-2414	487	11	h.	h.	PROPN
admet-2414	487	12	stassen	stassen	PROPN
admet-2414	487	13	,	,	PUNCT
admet-2414	487	14	g.m	g.m	PROPN
admet-2414	487	15	.	.	PROPN
admet-2414	487	16	russell	russell	PROPN
admet-2414	487	17	,	,	PUNCT
admet-2414	487	18	j.	j.	PROPN
admet-2414	487	19	leendertz	leendertz	PROPN
admet-2414	487	20	,	,	PUNCT
admet-2414	487	21	k.	k.	PROPN
admet-2414	487	22	stevens	stevens	PROPN
admet-2414	487	23	,	,	PUNCT
admet-2414	487	24	a.c.e	a.c.e	NOUN
admet-2414	487	25	.	.	PUNCT
admet-2414	488	1	linthorst	linthorst	ADV
admet-2414	488	2	,	,	PUNCT
admet-2414	488	3	s.l	s.l	PROPN
admet-2414	488	4	.	.	PUNCT
admet-2414	488	5	lightman	lightman	PROPN
admet-2414	488	6	.	.	PUNCT
admet-2414	489	1	continuous	continuous	ADJ
admet-2414	489	2	free	free	ADJ
admet-2414	489	3	cortisol	cortisol	ADJ
admet-2414	489	4	profiles	profile	NOUN
admet-2414	489	5	-	-	PUNCT
admet-2414	489	6	circadian	circadian	ADJ
admet-2414	489	7	rhythms	rhythm	NOUN
admet-2414	489	8	in	in	ADP
admet-2414	489	9	healthy	healthy	ADJ
admet-2414	489	10	men	man	NOUN
admet-2414	489	11	.	.	PUNCT
admet-2414	490	1	j	j	PROPN
admet-2414	490	2	clin	clin	PROPN
admet-2414	490	3	endocrinol	endocrinol	PROPN
admet-2414	490	4	metab	metab	PROPN
admet-2414	490	5	104	104	NUM
admet-2414	490	6	(	(	PUNCT
admet-2414	490	7	2019	2019	NUM
admet-2414	490	8	)	)	PUNCT
admet-2414	490	9	5935	5935	NUM
admet-2414	490	10	-	-	SYM
admet-2414	490	11	5947	5947	NUM
admet-2414	490	12	.	.	PUNCT
admet-2414	491	1	https://doi.org/10.1210/jc.2019-00449	https://doi.org/10.1210/jc.2019-00449	PROPN
admet-2414	491	2	.	.	PUNCT
admet-2414	492	1	[	[	X
admet-2414	492	2	42	42	NUM
admet-2414	492	3	]	]	PUNCT
admet-2414	492	4	t.	t.	PROPN
admet-2414	492	5	hirano	hirano	PROPN
admet-2414	492	6	,	,	PUNCT
admet-2414	492	7	k.	k.	PROPN
admet-2414	492	8	oka	oka	PROPN
admet-2414	492	9	,	,	PUNCT
admet-2414	492	10	h.	h.	PROPN
admet-2414	492	11	takeuchi	takeuchi	PROPN
admet-2414	492	12	,	,	PUNCT
admet-2414	492	13	e.	e.	PROPN
admet-2414	492	14	sakurai	sakurai	PROPN
admet-2414	492	15	,	,	PUNCT
admet-2414	492	16	k.	k.	PROPN
admet-2414	492	17	kozaki	kozaki	PROPN
admet-2414	492	18	,	,	PUNCT
admet-2414	492	19	n.	n.	PROPN
admet-2414	492	20	matsuno	matsuno	PROPN
admet-2414	492	21	,	,	PUNCT
admet-2414	492	22	m.	m.	NOUN
admet-2414	492	23	kozaki	kozaki	PROPN
admet-2414	492	24	,	,	PUNCT
admet-2414	492	25	t.	t.	PROPN
admet-2414	492	26	nagao	nagao	NOUN
admet-2414	492	27	.	.	PUNCT
admet-2414	493	1	a	a	DET
admet-2414	493	2	comparison	comparison	NOUN
admet-2414	493	3	of	of	ADP
admet-2414	493	4	prednisolone	prednisolone	PROPN
admet-2414	493	5	and	and	CCONJ
admet-2414	493	6	methylprednisolone	methylprednisolone	NOUN
admet-2414	493	7	for	for	ADP
admet-2414	493	8	renal	renal	ADJ
admet-2414	493	9	transplantation	transplantation	NOUN
admet-2414	493	10	.	.	PUNCT
admet-2414	494	1	clin	clin	PROPN
admet-2414	494	2	transplant	transplant	PROPN
admet-2414	494	3	14	14	NUM
admet-2414	494	4	(	(	PUNCT
admet-2414	494	5	2000	2000	NUM
admet-2414	494	6	)	)	PUNCT
admet-2414	494	7	323328	323328	NUM
admet-2414	494	8	.	.	PUNCT
admet-2414	495	1	https://doi.org/10.1034/j.1399-0012.2000.140408.x	https://doi.org/10.1034/j.1399-0012.2000.140408.x	NOUN
admet-2414	495	2	.	.	PUNCT
admet-2414	496	1	https://doi.org/10.1016/j.ejps.2021.105819	https://doi.org/10.1016/j.ejps.2021.105819	ADJ
admet-2414	496	2	https://doi.org/10.1016/s0039-128x(03)00032-1	https://doi.org/10.1016/s0039-128x(03)00032-1	ADJ
admet-2414	496	3	https://doi.org/10.1016/j.ejps.2012.10.003	https://doi.org/10.1016/j.ejps.2012.10.003	NOUN
admet-2414	496	4	https://doi.org/10.1016/j.biopha.2022.113218	https://doi.org/10.1016/j.biopha.2022.113218	NOUN
admet-2414	496	5	https://doi.org/10.1210/jc.2005-0646	https://doi.org/10.1210/jc.2005-0646	VERB
admet-2414	496	6	https://doi.org/10.1016/0016-5085(91)90740-c	https://doi.org/10.1016/0016-5085(91)90740-c	PROPN
admet-2414	496	7	https://doi.org/10.1016/0016-5085(91)90740-c	https://doi.org/10.1016/0016-5085(91)90740-c	PROPN
admet-2414	496	8	https://doi.org/10.1203/pdr.0b013e3181998db6	https://doi.org/10.1203/pdr.0b013e3181998db6	PROPN
admet-2414	496	9	https://doi.org/10.1016/s0039-128x(00)00235-x	https://doi.org/10.1016/s0039-128x(00)00235-x	PROPN
admet-2414	496	10	https://doi.org/10.1016/s0039-128x(00)00235-x	https://doi.org/10.1016/s0039-128x(00)00235-x	PROPN
admet-2414	496	11	https://doi.org/10.1177/1087057108322155	https://doi.org/10.1177/1087057108322155	X
admet-2414	496	12	https://doi.org/10.1210/jc.2004-2298	https://doi.org/10.1210/jc.2004-2298	X
admet-2414	496	13	https://doi.org/10.1165/ajrcmb.10.6.7516173	https://doi.org/10.1165/ajrcmb.10.6.7516173	PROPN
admet-2414	496	14	https://doi.org/10.2174/138620711795222446	https://doi.org/10.2174/138620711795222446	PROPN
admet-2414	496	15	https://doi.org/10.1210/jc.2019-00449	https://doi.org/10.1210/jc.2019-00449	NOUN
admet-2414	496	16	https://doi.org/10.1034/j.1399-0012.2000.140408.x	https://doi.org/10.1034/j.1399-0012.2000.140408.x	PROPN
admet-2414	496	17	admet	admet	PROPN
admet-2414	496	18	&	&	CCONJ
admet-2414	496	19	dmpk	dmpk	PROPN
admet-2414	496	20	12(6	12(6	NUM
admet-2414	496	21	)	)	PUNCT
admet-2414	496	22	(	(	PUNCT
admet-2414	496	23	2024	2024	NUM
admet-2414	496	24	)	)	PUNCT
admet-2414	496	25	971	971	NUM
admet-2414	496	26	-	-	SYM
admet-2414	496	27	989	989	NUM
admet-2414	496	28	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	496	29	/	/	SYM
admet-2414	496	30	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	496	31	of	of	ADP
admet-2414	496	32	glucocorticoids	glucocorticoid	NOUN
admet-2414	496	33	doi	doi	NOUN
admet-2414	496	34	:	:	PUNCT
admet-2414	496	35	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	496	36	989	989	NUM
admet-2414	497	1	[	[	X
admet-2414	497	2	43	43	NUM
admet-2414	497	3	]	]	PUNCT
admet-2414	497	4	r.	r.	PROPN
admet-2414	497	5	dhar	dhar	PROPN
admet-2414	497	6	,	,	PUNCT
admet-2414	497	7	c.	c.	PROPN
admet-2414	497	8	cotton	cotton	PROPN
admet-2414	497	9	,	,	PUNCT
admet-2414	497	10	j.	j.	PROPN
admet-2414	497	11	coleman	coleman	PROPN
admet-2414	497	12	,	,	PUNCT
admet-2414	497	13	d.	d.	PROPN
admet-2414	497	14	brockmeier	brockmeier	PROPN
admet-2414	497	15	,	,	PUNCT
admet-2414	497	16	d.	d.	PROPN
admet-2414	497	17	kappel	kappel	PROPN
admet-2414	497	18	,	,	PUNCT
admet-2414	497	19	g.	g.	PROPN
admet-2414	497	20	marklin	marklin	PROPN
admet-2414	497	21	,	,	PUNCT
admet-2414	497	22	r.	r.	PROPN
admet-2414	497	23	wright	wright	PROPN
admet-2414	497	24	.	.	PUNCT
admet-2414	498	1	comparison	comparison	NOUN
admet-2414	498	2	of	of	ADP
admet-2414	498	3	high	high	ADJ
admet-2414	498	4	and	and	CCONJ
admet-2414	498	5	low	low	ADV
admet-2414	498	6	-	-	PUNCT
admet-2414	498	7	dose	dose	NOUN
admet-2414	498	8	corticosteroid	corticosteroid	ADJ
admet-2414	498	9	regimens	regimen	NOUN
admet-2414	498	10	for	for	ADP
admet-2414	498	11	organ	organ	NOUN
admet-2414	498	12	donor	donor	NOUN
admet-2414	498	13	management	management	NOUN
admet-2414	498	14	.	.	PUNCT
admet-2414	499	1	j	j	PROPN
admet-2414	499	2	crit	crit	PROPN
admet-2414	499	3	care	care	PROPN
admet-2414	499	4	28	28	NUM
admet-2414	499	5	(	(	PUNCT
admet-2414	499	6	2013	2013	NUM
admet-2414	499	7	)	)	PUNCT
admet-2414	499	8	111	111	NUM
admet-2414	499	9	e111	e111	PROPN
admet-2414	499	10	-	-	SYM
admet-2414	499	11	117	117	NUM
admet-2414	499	12	.	.	PUNCT
admet-2414	500	1	https://doi.org/10.1016/j.jcrc.2012.04.015	https://doi.org/10.1016/j.jcrc.2012.04.015	NOUN
admet-2414	500	2	.	.	PUNCT
admet-2414	501	1	[	[	X
admet-2414	501	2	44	44	NUM
admet-2414	501	3	]	]	X
admet-2414	501	4	n.k	n.k	PROPN
admet-2414	501	5	.	.	PROPN
admet-2414	501	6	rathi	rathi	PROPN
admet-2414	501	7	,	,	PUNCT
admet-2414	501	8	a.r	a.r	PROPN
admet-2414	501	9	.	.	PROPN
admet-2414	501	10	tanner	tanner	PROPN
admet-2414	501	11	,	,	PUNCT
admet-2414	501	12	a.	a.	PROPN
admet-2414	501	13	dinh	dinh	PROPN
admet-2414	501	14	,	,	PUNCT
admet-2414	501	15	w.	w.	PROPN
admet-2414	501	16	dong	dong	PROPN
admet-2414	501	17	,	,	PUNCT
admet-2414	501	18	l.	l.	PROPN
admet-2414	501	19	feng	feng	PROPN
admet-2414	501	20	,	,	PUNCT
admet-2414	501	21	j.	j.	PROPN
admet-2414	501	22	ensor	ensor	PROPN
admet-2414	501	23	,	,	PUNCT
admet-2414	501	24	s.k	s.k	PROPN
admet-2414	501	25	.	.	PROPN
admet-2414	501	26	wallace	wallace	PROPN
admet-2414	501	27	,	,	PUNCT
admet-2414	501	28	s.a	s.a	PROPN
admet-2414	501	29	.	.	PROPN
admet-2414	501	30	haque	haque	PROPN
admet-2414	501	31	,	,	PUNCT
admet-2414	501	32	g.	g.	PROPN
admet-2414	501	33	rondon	rondon	PROPN
admet-2414	501	34	,	,	PUNCT
admet-2414	501	35	k.j	k.j	PROPN
admet-2414	501	36	.	.	PROPN
admet-2414	501	37	price	price	NOUN
admet-2414	501	38	,	,	PUNCT
admet-2414	501	39	u.	u.	PROPN
admet-2414	501	40	popat	popat	PROPN
admet-2414	501	41	,	,	PUNCT
admet-2414	501	42	j.l	j.l	PROPN
admet-2414	501	43	.	.	PROPN
admet-2414	501	44	nates	nate	NOUN
admet-2414	501	45	.	.	PUNCT
admet-2414	502	1	low-	low-	ADV
admet-2414	502	2	,	,	PUNCT
admet-2414	502	3	mediumand	mediumand	VERB
admet-2414	502	4	high	high	ADV
admet-2414	502	5	-	-	PUNCT
admet-2414	502	6	dose	dose	NOUN
admet-2414	502	7	steroids	steroid	NOUN
admet-2414	502	8	with	with	ADP
admet-2414	502	9	or	or	CCONJ
admet-2414	502	10	without	without	ADP
admet-2414	502	11	aminocaproic	aminocaproic	ADJ
admet-2414	502	12	acid	acid	NOUN
admet-2414	502	13	in	in	ADP
admet-2414	502	14	adult	adult	NOUN
admet-2414	502	15	hematopoietic	hematopoietic	ADJ
admet-2414	502	16	sct	sct	PROPN
admet-2414	502	17	patients	patient	NOUN
admet-2414	502	18	with	with	ADP
admet-2414	502	19	diffuse	diffuse	ADJ
admet-2414	502	20	alveolar	alveolar	ADJ
admet-2414	502	21	hemorrhage	hemorrhage	NOUN
admet-2414	502	22	.	.	PUNCT
admet-2414	503	1	bone	bone	NOUN
admet-2414	503	2	marrow	marrow	NOUN
admet-2414	503	3	transplant	transplant	VERB
admet-2414	503	4	50	50	NUM
admet-2414	503	5	(	(	PUNCT
admet-2414	503	6	2015	2015	NUM
admet-2414	503	7	)	)	PUNCT
admet-2414	503	8	420	420	NUM
admet-2414	503	9	-	-	SYM
admet-2414	503	10	426	426	NUM
admet-2414	503	11	.	.	PUNCT
admet-2414	504	1	https://doi.org/10.1038/bmt.2014.287	https://doi.org/10.1038/bmt.2014.287	PROPN
admet-2414	504	2	.	.	PUNCT
admet-2414	505	1	[	[	X
admet-2414	505	2	45	45	NUM
admet-2414	505	3	]	]	PUNCT
admet-2414	505	4	s.	s.	PROPN
admet-2414	505	5	rohatagi	rohatagi	PROPN
admet-2414	505	6	,	,	PUNCT
admet-2414	505	7	j.	j.	PROPN
admet-2414	505	8	barth	barth	PROPN
admet-2414	505	9	,	,	PUNCT
admet-2414	505	10	h.	h.	PROPN
admet-2414	505	11	mollmann	mollmann	PROPN
admet-2414	505	12	,	,	PUNCT
admet-2414	505	13	g.	g.	PROPN
admet-2414	505	14	hochhaus	hochhaus	PROPN
admet-2414	505	15	,	,	PUNCT
admet-2414	505	16	a.	a.	NOUN
admet-2414	505	17	soldner	soldner	PROPN
admet-2414	505	18	,	,	PUNCT
admet-2414	505	19	c.	c.	PROPN
admet-2414	505	20	mollmann	mollmann	PROPN
admet-2414	505	21	,	,	PUNCT
admet-2414	505	22	h.	h.	PROPN
admet-2414	505	23	derendorf	derendorf	PROPN
admet-2414	505	24	.	.	PUNCT
admet-2414	506	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	506	2	of	of	ADP
admet-2414	506	3	methylprednisolone	methylprednisolone	PROPN
admet-2414	506	4	and	and	CCONJ
admet-2414	506	5	prednisolone	prednisolone	PROPN
admet-2414	506	6	after	after	ADP
admet-2414	506	7	single	single	ADJ
admet-2414	506	8	and	and	CCONJ
admet-2414	506	9	multiple	multiple	ADJ
admet-2414	506	10	oral	oral	ADJ
admet-2414	506	11	administration	administration	NOUN
admet-2414	506	12	.	.	PUNCT
admet-2414	507	1	j	j	PROPN
admet-2414	507	2	clin	clin	PROPN
admet-2414	507	3	pharmacol	pharmacol	PROPN
admet-2414	507	4	37	37	NUM
admet-2414	507	5	(	(	PUNCT
admet-2414	507	6	1997	1997	NUM
admet-2414	507	7	)	)	PUNCT
admet-2414	507	8	916	916	NUM
admet-2414	507	9	-	-	SYM
admet-2414	507	10	925	925	NUM
admet-2414	507	11	.	.	PUNCT
admet-2414	508	1	https://doi.org/10.1002/j.15524604.1997.tb04266.x	https://doi.org/10.1002/j.15524604.1997.tb04266.x	ADJ
admet-2414	508	2	.	.	PUNCT
admet-2414	509	1	[	[	X
admet-2414	509	2	46	46	NUM
admet-2414	509	3	]	]	X
admet-2414	509	4	j.q	j.q	PROPN
admet-2414	509	5	.	.	PROPN
admet-2414	509	6	rose	rise	VERB
admet-2414	509	7	,	,	PUNCT
admet-2414	509	8	a.m.	a.m.	PROPN
admet-2414	509	9	yurchak	yurchak	PROPN
admet-2414	509	10	,	,	PUNCT
admet-2414	509	11	w.j	w.j	PROPN
admet-2414	509	12	.	.	PROPN
admet-2414	509	13	jusko	jusko	PROPN
admet-2414	509	14	.	.	PUNCT
admet-2414	510	1	dose	dose	VERB
admet-2414	510	2	dependent	dependent	ADJ
admet-2414	510	3	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	510	4	of	of	ADP
admet-2414	510	5	prednisone	prednisone	NOUN
admet-2414	510	6	and	and	CCONJ
admet-2414	510	7	prednisolone	prednisolone	PROPN
admet-2414	510	8	in	in	ADP
admet-2414	510	9	man	man	NOUN
admet-2414	510	10	.	.	PUNCT
admet-2414	511	1	j	j	PROPN
admet-2414	511	2	pharmacokinet	pharmacokinet	PROPN
admet-2414	511	3	biopharm	biopharm	PROPN
admet-2414	511	4	9	9	NUM
admet-2414	511	5	(	(	PUNCT
admet-2414	511	6	1981	1981	NUM
admet-2414	511	7	)	)	PUNCT
admet-2414	511	8	389	389	NUM
admet-2414	511	9	-	-	SYM
admet-2414	511	10	417	417	NUM
admet-2414	511	11	.	.	PUNCT
admet-2414	512	1	https://doi.org/10.1007/bf01060885	https://doi.org/10.1007/bf01060885	X
admet-2414	512	2	.	.	PUNCT
admet-2414	513	1	[	[	X
admet-2414	513	2	47	47	NUM
admet-2414	513	3	]	]	PUNCT
admet-2414	513	4	j.	j.	PROPN
admet-2414	513	5	xu	xu	PROPN
admet-2414	513	6	,	,	PUNCT
admet-2414	513	7	j.	j.	PROPN
admet-2414	513	8	winkler	winkler	PROPN
admet-2414	513	9	,	,	PUNCT
admet-2414	513	10	h.	h.	PROPN
admet-2414	513	11	derendorf	derendorf	PROPN
admet-2414	513	12	.	.	PUNCT
admet-2414	514	1	a	a	DET
admet-2414	514	2	pharmacokinetic	pharmacokinetic	ADJ
admet-2414	514	3	/	/	SYM
admet-2414	514	4	pharmacodynamic	pharmacodynamic	ADJ
admet-2414	514	5	approach	approach	NOUN
admet-2414	514	6	to	to	PART
admet-2414	514	7	predict	predict	VERB
admet-2414	514	8	total	total	ADJ
admet-2414	514	9	prednisolone	prednisolone	PROPN
admet-2414	514	10	concentrations	concentration	NOUN
admet-2414	514	11	in	in	ADP
admet-2414	514	12	human	human	ADJ
admet-2414	514	13	plasma	plasma	NOUN
admet-2414	514	14	.	.	PUNCT
admet-2414	515	1	j	j	PROPN
admet-2414	515	2	pharmacokinet	pharmacokinet	PROPN
admet-2414	515	3	pharmacodyn	pharmacodyn	ADV
admet-2414	515	4	34	34	NUM
admet-2414	515	5	(	(	PUNCT
admet-2414	515	6	2007	2007	NUM
admet-2414	515	7	)	)	PUNCT
admet-2414	515	8	355	355	NUM
admet-2414	515	9	-	-	SYM
admet-2414	515	10	372	372	NUM
admet-2414	515	11	.	.	PUNCT
admet-2414	515	12	https://doi.org/10.1007/s10928-007-9050-8	https://doi.org/10.1007/s10928-007-9050-8	NUM
admet-2414	515	13	.	.	PUNCT
admet-2414	516	1	[	[	X
admet-2414	516	2	48	48	NUM
admet-2414	516	3	]	]	PUNCT
admet-2414	516	4	m.	m.	NOUN
admet-2414	516	5	krasselt	krasselt	PROPN
admet-2414	516	6	,	,	PUNCT
admet-2414	516	7	c.	c.	PROPN
admet-2414	516	8	baerwald	baerwald	PROPN
admet-2414	516	9	.	.	PUNCT
admet-2414	517	1	the	the	DET
admet-2414	517	2	current	current	ADJ
admet-2414	517	3	relevance	relevance	NOUN
admet-2414	517	4	and	and	CCONJ
admet-2414	517	5	use	use	NOUN
admet-2414	517	6	of	of	ADP
admet-2414	517	7	prednisone	prednisone	NOUN
admet-2414	517	8	in	in	ADP
admet-2414	517	9	rheumatoid	rheumatoid	NOUN
admet-2414	517	10	arthritis	arthritis	NOUN
admet-2414	517	11	.	.	PUNCT
admet-2414	518	1	expert	expert	NOUN
admet-2414	518	2	rev	rev	VERB
admet-2414	518	3	clin	clin	PROPN
admet-2414	518	4	immunol	immunol	NOUN
admet-2414	518	5	10	10	NUM
admet-2414	518	6	(	(	PUNCT
admet-2414	518	7	2014	2014	NUM
admet-2414	518	8	)	)	PUNCT
admet-2414	518	9	557	557	NUM
admet-2414	518	10	-	-	SYM
admet-2414	518	11	571	571	NUM
admet-2414	518	12	.	.	PUNCT
admet-2414	519	1	https://doi.org/10.1586/1744666x.2014.904746	https://doi.org/10.1586/1744666x.2014.904746	X
admet-2414	519	2	.	.	PUNCT
admet-2414	520	1	[	[	X
admet-2414	520	2	49	49	NUM
admet-2414	520	3	]	]	X
admet-2414	520	4	m.j	m.j	PROPN
admet-2414	520	5	.	.	PROPN
admet-2414	520	6	schaaf	schaaf	PROPN
admet-2414	520	7	,	,	PUNCT
admet-2414	520	8	l.j	l.j	PROPN
admet-2414	520	9	.	.	PROPN
admet-2414	520	10	lewis	lewis	PROPN
admet-2414	520	11	-	-	PUNCT
admet-2414	520	12	tuffin	tuffin	PROPN
admet-2414	520	13	,	,	PUNCT
admet-2414	520	14	j.a	j.a	PROPN
admet-2414	520	15	.	.	PROPN
admet-2414	520	16	cidlowski	cidlowski	PROPN
admet-2414	520	17	.	.	PUNCT
admet-2414	521	1	ligand	ligand	NOUN
admet-2414	521	2	-	-	PUNCT
admet-2414	521	3	selective	selective	ADJ
admet-2414	521	4	targeting	targeting	NOUN
admet-2414	521	5	of	of	ADP
admet-2414	521	6	the	the	DET
admet-2414	521	7	glucocorticoid	glucocorticoid	ADJ
admet-2414	521	8	receptor	receptor	NOUN
admet-2414	521	9	to	to	ADP
admet-2414	521	10	nuclear	nuclear	ADJ
admet-2414	521	11	subdomains	subdomain	NOUN
admet-2414	521	12	is	be	AUX
admet-2414	521	13	associated	associate	VERB
admet-2414	521	14	with	with	ADP
admet-2414	521	15	decreased	decrease	VERB
admet-2414	521	16	receptor	receptor	NOUN
admet-2414	521	17	mobility	mobility	NOUN
admet-2414	521	18	.	.	PUNCT
admet-2414	522	1	mol	mol	ADP
admet-2414	522	2	endocrinol	endocrinol	NOUN
admet-2414	522	3	19	19	NUM
admet-2414	522	4	(	(	PUNCT
admet-2414	522	5	2005	2005	NUM
admet-2414	522	6	)	)	PUNCT
admet-2414	522	7	1501	1501	NUM
admet-2414	522	8	-	-	SYM
admet-2414	522	9	1515	1515	NUM
admet-2414	522	10	.	.	PUNCT
admet-2414	523	1	https://doi.org/10.1210/me.2005-0050	https://doi.org/10.1210/me.2005-0050	PROPN
admet-2414	523	2	.	.	PUNCT
admet-2414	524	1	[	[	X
admet-2414	524	2	50	50	NUM
admet-2414	524	3	]	]	PUNCT
admet-2414	524	4	d.	d.	PROPN
admet-2414	524	5	czock	czock	PROPN
admet-2414	524	6	,	,	PUNCT
admet-2414	524	7	f.	f.	PROPN
admet-2414	524	8	keller	keller	PROPN
admet-2414	524	9	,	,	PUNCT
admet-2414	524	10	f.m	f.m	PROPN
admet-2414	524	11	.	.	PROPN
admet-2414	524	12	rasche	rasche	PROPN
admet-2414	524	13	,	,	PUNCT
admet-2414	524	14	u.	u.	NOUN
admet-2414	524	15	haussler	haussler	NOUN
admet-2414	524	16	.	.	PUNCT
admet-2414	525	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2414	525	2	and	and	CCONJ
admet-2414	525	3	pharmacodynamics	pharmacodynamic	NOUN
admet-2414	525	4	of	of	ADP
admet-2414	525	5	systemically	systemically	ADV
admet-2414	525	6	administered	administer	VERB
admet-2414	525	7	glucocorticoids	glucocorticoid	NOUN
admet-2414	525	8	.	.	PUNCT
admet-2414	526	1	clin	clin	PROPN
admet-2414	526	2	pharmacokinet	pharmacokinet	PROPN
admet-2414	526	3	44	44	NUM
admet-2414	526	4	(	(	PUNCT
admet-2414	526	5	2005	2005	NUM
admet-2414	526	6	)	)	PUNCT
admet-2414	526	7	61	61	NUM
admet-2414	526	8	-	-	SYM
admet-2414	526	9	98	98	NUM
admet-2414	526	10	.	.	PUNCT
admet-2414	527	1	https://doi.org/10.2165/00003088-200544010-00003	https://doi.org/10.2165/00003088-200544010-00003	NOUN
admet-2414	527	2	.	.	PUNCT
admet-2414	528	1	[	[	X
admet-2414	528	2	51	51	NUM
admet-2414	528	3	]	]	X
admet-2414	528	4	m.d	m.d	PROPN
admet-2414	528	5	.	.	PROPN
admet-2414	528	6	heitzer	heitzer	PROPN
admet-2414	528	7	,	,	PUNCT
admet-2414	528	8	i.m	i.m	PROPN
admet-2414	528	9	.	.	PROPN
admet-2414	528	10	wolf	wolf	PROPN
admet-2414	528	11	,	,	PUNCT
admet-2414	528	12	e.r	e.r	PROPN
admet-2414	528	13	.	.	PROPN
admet-2414	528	14	sanchez	sanchez	PROPN
admet-2414	528	15	,	,	PUNCT
admet-2414	528	16	s.f	s.f	PROPN
admet-2414	528	17	.	.	PROPN
admet-2414	528	18	witchel	witchel	PROPN
admet-2414	528	19	,	,	PUNCT
admet-2414	528	20	d.b	d.b	PROPN
admet-2414	528	21	.	.	PROPN
admet-2414	528	22	defranco	defranco	PROPN
admet-2414	528	23	.	.	PUNCT
admet-2414	529	1	glucocorticoid	glucocorticoid	ADJ
admet-2414	529	2	receptor	receptor	NOUN
admet-2414	529	3	physiology	physiology	NOUN
admet-2414	529	4	.	.	PUNCT
admet-2414	530	1	rev	rev	PROPN
admet-2414	530	2	endocr	endocr	PROPN
admet-2414	530	3	metab	metab	PROPN
admet-2414	530	4	disord	disord	NOUN
admet-2414	530	5	8	8	NUM
admet-2414	530	6	(	(	PUNCT
admet-2414	530	7	2007	2007	NUM
admet-2414	530	8	)	)	PUNCT
admet-2414	530	9	321	321	NUM
admet-2414	530	10	-	-	SYM
admet-2414	530	11	330	330	NUM
admet-2414	530	12	.	.	PUNCT
admet-2414	530	13	https://doi.org/10.1007/s11154-007-9059-8	https://doi.org/10.1007/s11154-007-9059-8	NUM
admet-2414	530	14	.	.	PUNCT
admet-2414	531	1	[	[	X
admet-2414	531	2	52	52	NUM
admet-2414	531	3	]	]	X
admet-2414	531	4	a.d	a.d	PROPN
admet-2414	531	5	.	.	PROPN
admet-2414	531	6	wallace	wallace	PROPN
admet-2414	531	7	,	,	PUNCT
admet-2414	531	8	j.a	j.a	PROPN
admet-2414	531	9	.	.	PROPN
admet-2414	531	10	cidlowski	cidlowski	PROPN
admet-2414	531	11	.	.	PUNCT
admet-2414	532	1	proteasome	proteasome	NOUN
admet-2414	532	2	-	-	PUNCT
admet-2414	532	3	mediated	mediate	VERB
admet-2414	532	4	glucocorticoid	glucocorticoid	ADJ
admet-2414	532	5	receptor	receptor	NOUN
admet-2414	532	6	degradation	degradation	NOUN
admet-2414	532	7	restricts	restrict	VERB
admet-2414	532	8	transcriptional	transcriptional	NOUN
admet-2414	532	9	signaling	signal	VERB
admet-2414	532	10	by	by	ADP
admet-2414	532	11	glucocorticoids	glucocorticoid	NOUN
admet-2414	532	12	.	.	PUNCT
admet-2414	533	1	j	j	PROPN
admet-2414	533	2	biol	biol	PROPN
admet-2414	533	3	chem	chem	NOUN
admet-2414	533	4	276	276	NUM
admet-2414	533	5	(	(	PUNCT
admet-2414	533	6	2001	2001	NUM
admet-2414	533	7	)	)	PUNCT
admet-2414	533	8	42714	42714	NUM
admet-2414	533	9	-	-	SYM
admet-2414	533	10	42721	42721	NUM
admet-2414	533	11	.	.	PUNCT
admet-2414	534	1	https://doi.org/10.1074/jbc.m106033200	https://doi.org/10.1074/jbc.m106033200	X
admet-2414	534	2	.	.	PUNCT
admet-2414	535	1	©	©	PROPN
admet-2414	535	2	2024	2024	NUM
admet-2414	535	3	by	by	ADP
admet-2414	535	4	the	the	DET
admet-2414	535	5	authors	author	NOUN
admet-2414	535	6	;	;	PUNCT
admet-2414	535	7	licensee	licensee	PROPN
admet-2414	535	8	iapc	iapc	PROPN
admet-2414	535	9	,	,	PUNCT
admet-2414	535	10	zagreb	zagreb	PROPN
admet-2414	535	11	,	,	PUNCT
admet-2414	535	12	croatia	croatia	PROPN
admet-2414	535	13	.	.	PUNCT
admet-2414	536	1	this	this	DET
admet-2414	536	2	article	article	NOUN
admet-2414	536	3	is	be	AUX
admet-2414	536	4	an	an	DET
admet-2414	536	5	open	open	ADJ
admet-2414	536	6	-	-	PUNCT
admet-2414	536	7	access	access	NOUN
admet-2414	536	8	article	article	NOUN
admet-2414	536	9	distributed	distribute	VERB
admet-2414	536	10	under	under	ADP
admet-2414	536	11	the	the	DET
admet-2414	536	12	terms	term	NOUN
admet-2414	536	13	and	and	CCONJ
admet-2414	536	14	conditions	condition	NOUN
admet-2414	536	15	of	of	ADP
admet-2414	536	16	the	the	DET
admet-2414	536	17	creative	creative	ADJ
admet-2414	536	18	commons	common	NOUN
admet-2414	536	19	attribution	attribution	NOUN
admet-2414	536	20	license	license	NOUN
admet-2414	536	21	(	(	PUNCT
admet-2414	536	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN
admet-2414	536	23	)	)	PUNCT
admet-2414	536	24	https://doi.org/10.5599/admet.2414	https://doi.org/10.5599/admet.2414	NOUN
admet-2414	536	25	https://doi.org/10.1016/j.jcrc.2012.04.015	https://doi.org/10.1016/j.jcrc.2012.04.015	VERB
admet-2414	536	26	https://doi.org/10.1038/bmt.2014.287	https://doi.org/10.1038/bmt.2014.287	PRON
admet-2414	537	1	https://doi.org/10.1002/j.1552-4604.1997.tb04266.x	https://doi.org/10.1002/j.1552-4604.1997.tb04266.x	PROPN
admet-2414	537	2	https://doi.org/10.1002/j.1552-4604.1997.tb04266.x	https://doi.org/10.1002/j.1552-4604.1997.tb04266.x	PROPN
admet-2414	537	3	https://doi.org/10.1007/bf01060885	https://doi.org/10.1007/bf01060885	NOUN
admet-2414	537	4	https://doi.org/10.1007/s10928-007-9050-8	https://doi.org/10.1007/s10928-007-9050-8	NUM
admet-2414	537	5	https://doi.org/10.1586/1744666x.2014.904746	https://doi.org/10.1586/1744666x.2014.904746	ADV
admet-2414	537	6	https://doi.org/10.1210/me.2005-0050	https://doi.org/10.1210/me.2005-0050	X
admet-2414	537	7	https://doi.org/10.2165/00003088-200544010-00003	https://doi.org/10.2165/00003088-200544010-00003	PROPN
admet-2414	537	8	https://doi.org/10.1007/s11154-007-9059-8	https://doi.org/10.1007/s11154-007-9059-8	NUM
admet-2414	537	9	https://doi.org/10.1074/jbc.m106033200	https://doi.org/10.1074/jbc.m106033200	X
admet-2414	537	10	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN