id	sid	tid	token	lemma	pos
admet-2415	1	1	what	what	PRON
admet-2415	1	2	matters	matter	VERB
admet-2415	1	3	for	for	ADP
admet-2415	1	4	drug	drug	NOUN
admet-2415	1	5	delivery	delivery	NOUN
admet-2415	1	6	to	to	PART
admet-2415	1	7	tumor	tumor	VERB
admet-2415	1	8	by	by	ADP
admet-2415	1	9	nanoparticles	nanoparticle	NOUN
admet-2415	1	10	:	:	PUNCT
admet-2415	1	11	gaining	gain	VERB
admet-2415	1	12	insights	insight	NOUN
admet-2415	1	13	from	from	ADP
admet-2415	1	14	pbpk	pbpk	PROPN
admet-2415	1	15	/	/	SYM
admet-2415	1	16	pd	pd	PROPN
admet-2415	1	17	simulation	simulation	NOUN
admet-2415	1	18	of	of	ADP
admet-2415	1	19	drug	drug	NOUN
admet-2415	1	20	nanocrystals	nanocrystal	NOUN
admet-2415	1	21	doi	doi	NOUN
admet-2415	1	22	:	:	PUNCT
admet-2415	1	23	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	1	24	705	705	NUM
admet-2415	1	25	admet	admet	X
admet-2415	1	26	&	&	CCONJ
admet-2415	1	27	dmpk	dmpk	PROPN
admet-2415	1	28	12(5	12(5	NUM
admet-2415	1	29	)	)	PUNCT
admet-2415	1	30	(	(	PUNCT
admet-2415	1	31	2024	2024	NUM
admet-2415	1	32	)	)	PUNCT
admet-2415	1	33	705	705	NUM
admet-2415	1	34	-	-	SYM
admet-2415	1	35	719	719	NUM
admet-2415	1	36	;	;	PUNCT
admet-2415	1	37	doi	doi	NOUN
admet-2415	1	38	:	:	PUNCT
admet-2415	1	39	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	1	40	open	open	ADJ
admet-2415	1	41	access	access	NOUN
admet-2415	1	42	:	:	PUNCT
admet-2415	1	43	issn	issn	PROPN
admet-2415	1	44	:	:	PUNCT
admet-2415	1	45	1848	1848	NUM
admet-2415	1	46	-	-	SYM
admet-2415	1	47	7718	7718	NUM
admet-2415	1	48	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2415	1	49	original	original	ADJ
admet-2415	1	50	scientific	scientific	ADJ
admet-2415	1	51	paper	paper	NOUN
admet-2415	1	52	what	what	PRON
admet-2415	1	53	matters	matter	VERB
admet-2415	1	54	for	for	ADP
admet-2415	1	55	drug	drug	NOUN
admet-2415	1	56	delivery	delivery	NOUN
admet-2415	1	57	to	to	PART
admet-2415	1	58	tumor	tumor	VERB
admet-2415	1	59	by	by	ADP
admet-2415	1	60	nanoparticles	nanoparticle	NOUN
admet-2415	1	61	:	:	PUNCT
admet-2415	1	62	gaining	gain	VERB
admet-2415	1	63	insights	insight	NOUN
admet-2415	1	64	from	from	ADP
admet-2415	1	65	pbpk	pbpk	PROPN
admet-2415	1	66	/	/	SYM
admet-2415	1	67	pd	pd	PROPN
admet-2415	1	68	simulation	simulation	NOUN
admet-2415	1	69	of	of	ADP
admet-2415	1	70	drug	drug	NOUN
admet-2415	1	71	nanocrystals	nanocrystals	PROPN
admet-2415	1	72	shan	shan	PROPN
admet-2415	1	73	lu	lu	PROPN
admet-2415	1	74	,	,	PUNCT
admet-2415	1	75	clairissa	clairissa	PROPN
admet-2415	1	76	d.	d.	PROPN
admet-2415	1	77	corpstein	corpstein	PROPN
admet-2415	1	78	,	,	PUNCT
admet-2415	1	79	kinam	kinam	PROPN
admet-2415	1	80	park	park	PROPN
admet-2415	1	81	and	and	CCONJ
admet-2415	1	82	tonglei	tonglei	VERB
admet-2415	1	83	li	li	PROPN
admet-2415	1	84	*	*	PROPN
admet-2415	1	85	1department	1department	NUM
admet-2415	1	86	of	of	ADP
admet-2415	1	87	industrial	industrial	PROPN
admet-2415	1	88	&	&	CCONJ
admet-2415	1	89	physical	physical	ADJ
admet-2415	1	90	pharmacy	pharmacy	PROPN
admet-2415	1	91	,	,	PUNCT
admet-2415	1	92	purdue	purdue	PROPN
admet-2415	1	93	university	university	NOUN
admet-2415	1	94	,	,	PUNCT
admet-2415	1	95	west	west	PROPN
admet-2415	1	96	lafayette	lafayette	PROPN
admet-2415	1	97	,	,	PUNCT
admet-2415	1	98	indiana	indiana	PROPN
admet-2415	1	99	,	,	PUNCT
admet-2415	1	100	united	united	PROPN
admet-2415	1	101	states	states	PROPN
admet-2415	1	102	*	*	PUNCT
admet-2415	1	103	corresponding	correspond	VERB
admet-2415	1	104	author	author	NOUN
admet-2415	1	105	:	:	PUNCT
admet-2415	1	106	e	e	NOUN
admet-2415	1	107	-	-	NOUN
admet-2415	1	108	mail	mail	NOUN
admet-2415	1	109	:	:	PUNCT
admet-2415	2	1	tonglei@purdue.edu	tonglei@purdue.edu	ADP
admet-2415	2	2	;	;	PUNCT
admet-2415	2	3	tel	tel	PROPN
admet-2415	2	4	.	.	PROPN
admet-2415	2	5	:	:	PUNCT
admet-2415	2	6	(	(	PUNCT
admet-2415	2	7	765	765	NUM
admet-2415	2	8	)	)	PUNCT
admet-2415	2	9	494	494	NUM
admet-2415	2	10	-	-	SYM
admet-2415	2	11	1451	1451	NUM
admet-2415	2	12	received	receive	VERB
admet-2415	2	13	:	:	PUNCT
admet-2415	2	14	may	may	AUX
admet-2415	2	15	18	18	NUM
admet-2415	2	16	,	,	PUNCT
admet-2415	2	17	2024	2024	NUM
admet-2415	2	18	;	;	PUNCT
admet-2415	2	19	revised	revise	VERB
admet-2415	2	20	:	:	PUNCT
admet-2415	2	21	july	july	PROPN
admet-2415	2	22	16	16	NUM
admet-2415	2	23	;	;	PUNCT
admet-2415	2	24	published	publish	VERB
admet-2415	2	25	:	:	PUNCT
admet-2415	2	26	july	july	PROPN
admet-2415	2	27	23	23	NUM
admet-2415	2	28	,	,	PUNCT
admet-2415	2	29	2024	2024	NUM
admet-2415	2	30	abstract	abstract	ADJ
admet-2415	2	31	background	background	NOUN
admet-2415	2	32	and	and	CCONJ
admet-2415	2	33	purpose	purpose	NOUN
admet-2415	2	34	:	:	PUNCT
admet-2415	2	35	in	in	ADP
admet-2415	2	36	our	our	PRON
admet-2415	2	37	previous	previous	ADJ
admet-2415	2	38	studies	study	NOUN
admet-2415	2	39	,	,	PUNCT
admet-2415	2	40	drug	drug	NOUN
admet-2415	2	41	nanocrystals	nanocrystal	NOUN
admet-2415	2	42	were	be	AUX
admet-2415	2	43	directly	directly	ADV
admet-2415	2	44	prepared	prepare	VERB
admet-2415	2	45	by	by	ADP
admet-2415	2	46	solution	solution	NOUN
admet-2415	2	47	crystallization	crystallization	NOUN
admet-2415	2	48	,	,	PUNCT
admet-2415	2	49	possessing	possess	VERB
admet-2415	2	50	uniform	uniform	ADJ
admet-2415	2	51	particle	particle	NOUN
admet-2415	2	52	size	size	NOUN
admet-2415	2	53	and	and	CCONJ
admet-2415	2	54	morphology	morphology	NOUN
admet-2415	2	55	suitable	suitable	ADJ
admet-2415	2	56	for	for	ADP
admet-2415	2	57	intravenous	intravenous	ADJ
admet-2415	2	58	(	(	PUNCT
admet-2415	2	59	iv	iv	X
admet-2415	2	60	)	)	PUNCT
admet-2415	2	61	injection	injection	NOUN
admet-2415	2	62	.	.	PUNCT
admet-2415	3	1	these	these	DET
admet-2415	3	2	nanocrystals	nanocrystal	NOUN
admet-2415	3	3	accumulated	accumulate	VERB
admet-2415	3	4	in	in	ADP
admet-2415	3	5	a	a	DET
admet-2415	3	6	small	small	ADJ
admet-2415	3	7	percentage	percentage	NOUN
admet-2415	3	8	of	of	ADP
admet-2415	3	9	their	their	PRON
admet-2415	3	10	injected	inject	VERB
admet-2415	3	11	dose	dose	NOUN
admet-2415	3	12	in	in	ADP
admet-2415	3	13	tumor	tumor	NOUN
admet-2415	3	14	-	-	PUNCT
admet-2415	3	15	bearing	bear	VERB
admet-2415	3	16	mice	mouse	NOUN
admet-2415	3	17	but	but	CCONJ
admet-2415	3	18	showed	show	VERB
admet-2415	3	19	similar	similar	ADJ
admet-2415	3	20	anti	anti	ADJ
admet-2415	3	21	-	-	ADJ
admet-2415	3	22	tumor	tumor	ADJ
admet-2415	3	23	effectiveness	effectiveness	NOUN
admet-2415	3	24	and	and	CCONJ
admet-2415	3	25	much	much	ADV
admet-2415	3	26	-	-	PUNCT
admet-2415	3	27	reduced	reduce	VERB
admet-2415	3	28	side	side	NOUN
admet-2415	3	29	effects	effect	NOUN
admet-2415	3	30	compared	compare	VERB
admet-2415	3	31	with	with	ADP
admet-2415	3	32	current	current	ADJ
admet-2415	3	33	commercial	commercial	NOUN
admet-2415	3	34	solubilized	solubilize	VERB
admet-2415	3	35	and	and	CCONJ
admet-2415	3	36	encapsulated	encapsulate	VERB
admet-2415	3	37	delivery	delivery	NOUN
admet-2415	3	38	systems	system	NOUN
admet-2415	3	39	.	.	PUNCT
admet-2415	4	1	experimental	experimental	ADJ
admet-2415	4	2	approach	approach	NOUN
admet-2415	4	3	:	:	PUNCT
admet-2415	4	4	in	in	ADP
admet-2415	4	5	this	this	DET
admet-2415	4	6	study	study	NOUN
admet-2415	4	7	,	,	PUNCT
admet-2415	4	8	we	we	PRON
admet-2415	4	9	aimed	aim	VERB
admet-2415	4	10	to	to	PART
admet-2415	4	11	delineate	delineate	VERB
admet-2415	4	12	possible	possible	ADJ
admet-2415	4	13	controlling	controlling	NOUN
admet-2415	4	14	factors	factor	NOUN
admet-2415	4	15	for	for	ADP
admet-2415	4	16	the	the	DET
admet-2415	4	17	pharmacokinetics	pharmacokinetic	NOUN
admet-2415	4	18	(	(	PUNCT
admet-2415	4	19	pk	pk	NOUN
admet-2415	4	20	)	)	PUNCT
admet-2415	4	21	and	and	CCONJ
admet-2415	4	22	biodistribution	biodistribution	NOUN
admet-2415	4	23	behaviors	behavior	NOUN
admet-2415	4	24	of	of	ADP
admet-2415	4	25	paclitaxel	paclitaxel	PROPN
admet-2415	4	26	(	(	PUNCT
admet-2415	4	27	ptx	ptx	NOUN
admet-2415	4	28	)	)	PUNCT
admet-2415	4	29	nanocrystals	nanocrystal	NOUN
admet-2415	4	30	tested	test	VERB
admet-2415	4	31	in	in	ADP
admet-2415	4	32	mice	mouse	NOUN
admet-2415	4	33	by	by	ADP
admet-2415	4	34	applying	apply	VERB
admet-2415	4	35	physiologically	physiologically	ADV
admet-2415	4	36	based	base	VERB
admet-2415	4	37	pharmacokinetics	pharmacokinetic	NOUN
admet-2415	4	38	(	(	PUNCT
admet-2415	4	39	pbpk	pbpk	NOUN
admet-2415	4	40	)	)	PUNCT
admet-2415	4	41	modeling	modeling	NOUN
admet-2415	4	42	,	,	PUNCT
admet-2415	4	43	coupled	couple	VERB
admet-2415	4	44	with	with	ADP
admet-2415	4	45	pharmacodynamics	pharmacodynamic	NOUN
admet-2415	4	46	(	(	PUNCT
admet-2415	4	47	pd	pd	NOUN
admet-2415	4	48	)	)	PUNCT
admet-2415	4	49	simulation	simulation	NOUN
admet-2415	4	50	,	,	PUNCT
admet-2415	4	51	to	to	ADP
admet-2415	4	52	the	the	DET
admet-2415	4	53	data	datum	NOUN
admet-2415	4	54	.	.	PUNCT
admet-2415	5	1	key	key	ADJ
admet-2415	5	2	results	result	NOUN
admet-2415	5	3	:	:	PUNCT
admet-2415	5	4	our	our	PRON
admet-2415	5	5	results	result	NOUN
admet-2415	5	6	show	show	VERB
admet-2415	5	7	that	that	SCONJ
admet-2415	5	8	clearance	clearance	NOUN
admet-2415	5	9	of	of	ADP
admet-2415	5	10	the	the	DET
admet-2415	5	11	drug	drug	NOUN
admet-2415	5	12	plays	play	VERB
admet-2415	5	13	a	a	DET
admet-2415	5	14	significant	significant	ADJ
admet-2415	5	15	,	,	PUNCT
admet-2415	5	16	if	if	SCONJ
admet-2415	5	17	not	not	PART
admet-2415	5	18	the	the	DET
admet-2415	5	19	most	most	ADV
admet-2415	5	20	important	important	ADJ
admet-2415	5	21	,	,	PUNCT
admet-2415	5	22	role	role	NOUN
admet-2415	5	23	in	in	ADP
admet-2415	5	24	determining	determine	VERB
admet-2415	5	25	tissue	tissue	NOUN
admet-2415	5	26	distribution	distribution	NOUN
admet-2415	5	27	,	,	PUNCT
admet-2415	5	28	including	include	VERB
admet-2415	5	29	tumor	tumor	NOUN
admet-2415	5	30	accumulation	accumulation	NOUN
admet-2415	5	31	of	of	ADP
admet-2415	5	32	ptx	ptx	NOUN
admet-2415	5	33	nanocrystals	nanocrystal	NOUN
admet-2415	5	34	.	.	PUNCT
admet-2415	6	1	surface	surface	NOUN
admet-2415	6	2	treatment	treatment	NOUN
admet-2415	6	3	of	of	ADP
admet-2415	6	4	drug	drug	NOUN
admet-2415	6	5	nanocrystals	nanocrystal	NOUN
admet-2415	6	6	with	with	ADP
admet-2415	6	7	polymeric	polymeric	ADJ
admet-2415	6	8	surfactants	surfactant	NOUN
admet-2415	6	9	also	also	ADV
admet-2415	6	10	appeared	appear	VERB
admet-2415	6	11	to	to	PART
admet-2415	6	12	affect	affect	VERB
admet-2415	6	13	pk	pk	NOUN
admet-2415	6	14	profiles	profile	NOUN
admet-2415	6	15	and	and	CCONJ
admet-2415	6	16	pd	pd	NOUN
admet-2415	6	17	outcomes	outcome	NOUN
admet-2415	6	18	.	.	PUNCT
admet-2415	7	1	importantly	importantly	ADV
admet-2415	7	2	,	,	PUNCT
admet-2415	7	3	when	when	SCONJ
admet-2415	7	4	scaled	scale	VERB
admet-2415	7	5	to	to	AUX
admet-2415	7	6	model	model	VERB
admet-2415	7	7	human	human	ADJ
admet-2415	7	8	parameters	parameter	NOUN
admet-2415	7	9	,	,	PUNCT
admet-2415	7	10	our	our	PRON
admet-2415	7	11	pk	pk	NOUN
admet-2415	7	12	/	/	SYM
admet-2415	7	13	pd	pd	NOUN
admet-2415	7	14	simulations	simulation	NOUN
admet-2415	7	15	suggest	suggest	VERB
admet-2415	7	16	that	that	SCONJ
admet-2415	7	17	drug	drug	NOUN
admet-2415	7	18	distribution	distribution	NOUN
admet-2415	7	19	in	in	ADP
admet-2415	7	20	humans	human	NOUN
admet-2415	7	21	,	,	PUNCT
admet-2415	7	22	as	as	SCONJ
admet-2415	7	23	opposed	oppose	VERB
admet-2415	7	24	to	to	ADP
admet-2415	7	25	animal	animal	NOUN
admet-2415	7	26	models	model	NOUN
admet-2415	7	27	,	,	PUNCT
admet-2415	7	28	was	be	AUX
admet-2415	7	29	significantly	significantly	ADV
admet-2415	7	30	influenced	influence	VERB
admet-2415	7	31	by	by	ADP
admet-2415	7	32	tissue	tissue	NOUN
admet-2415	7	33	partitioning	partition	VERB
admet-2415	7	34	rather	rather	ADV
admet-2415	7	35	than	than	ADP
admet-2415	7	36	drug	drug	NOUN
admet-2415	7	37	clearance	clearance	NOUN
admet-2415	7	38	.	.	PUNCT
admet-2415	8	1	this	this	DET
admet-2415	8	2	finding	finding	NOUN
admet-2415	8	3	could	could	AUX
admet-2415	8	4	facilitate	facilitate	VERB
admet-2415	8	5	the	the	DET
admet-2415	8	6	design	design	NOUN
admet-2415	8	7	and	and	CCONJ
admet-2415	8	8	development	development	NOUN
admet-2415	8	9	of	of	ADP
admet-2415	8	10	future	future	ADJ
admet-2415	8	11	drug	drug	NOUN
admet-2415	8	12	delivery	delivery	NOUN
admet-2415	8	13	systems	system	NOUN
admet-2415	8	14	.	.	PUNCT
admet-2415	9	1	conclusion	conclusion	NOUN
admet-2415	9	2	:	:	PUNCT
admet-2415	9	3	drug	drug	NOUN
admet-2415	9	4	nanocrystals	nanocrystal	NOUN
admet-2415	9	5	deposited	deposit	VERB
admet-2415	9	6	in	in	ADP
admet-2415	9	7	tissues	tissue	NOUN
admet-2415	9	8	,	,	PUNCT
admet-2415	9	9	including	include	VERB
admet-2415	9	10	tumors	tumor	NOUN
admet-2415	9	11	,	,	PUNCT
admet-2415	9	12	could	could	AUX
admet-2415	9	13	therefore	therefore	ADV
admet-2415	9	14	act	act	VERB
admet-2415	9	15	as	as	ADP
admet-2415	9	16	depots	depot	NOUN
admet-2415	9	17	,	,	PUNCT
admet-2415	9	18	releasing	release	VERB
admet-2415	9	19	the	the	DET
admet-2415	9	20	drug	drug	NOUN
admet-2415	9	21	back	back	ADV
admet-2415	9	22	into	into	ADP
admet-2415	9	23	the	the	DET
admet-2415	9	24	circulation	circulation	NOUN
admet-2415	9	25	,	,	PUNCT
admet-2415	9	26	possibly	possibly	ADV
admet-2415	9	27	contributing	contribute	VERB
admet-2415	9	28	to	to	ADP
admet-2415	9	29	extended	extended	ADJ
admet-2415	9	30	treatment	treatment	NOUN
admet-2415	9	31	,	,	PUNCT
admet-2415	9	32	as	as	ADV
admet-2415	9	33	well	well	ADV
admet-2415	9	34	as	as	ADP
admet-2415	9	35	any	any	DET
admet-2415	9	36	detrimental	detrimental	ADJ
admet-2415	9	37	effects	effect	NOUN
admet-2415	9	38	.	.	PUNCT
admet-2415	10	1	©	©	ADP
admet-2415	10	2	2024	2024	NUM
admet-2415	10	3	by	by	ADP
admet-2415	10	4	the	the	DET
admet-2415	10	5	authors	author	NOUN
admet-2415	10	6	.	.	PUNCT
admet-2415	11	1	this	this	DET
admet-2415	11	2	article	article	NOUN
admet-2415	11	3	is	be	AUX
admet-2415	11	4	an	an	DET
admet-2415	11	5	open	open	ADJ
admet-2415	11	6	-	-	PUNCT
admet-2415	11	7	access	access	NOUN
admet-2415	11	8	article	article	NOUN
admet-2415	11	9	distributed	distribute	VERB
admet-2415	11	10	under	under	ADP
admet-2415	11	11	the	the	DET
admet-2415	11	12	terms	term	NOUN
admet-2415	11	13	and	and	CCONJ
admet-2415	11	14	conditions	condition	NOUN
admet-2415	11	15	of	of	ADP
admet-2415	11	16	the	the	DET
admet-2415	11	17	creative	creative	ADJ
admet-2415	11	18	commons	common	NOUN
admet-2415	11	19	attribution	attribution	NOUN
admet-2415	11	20	license	license	NOUN
admet-2415	11	21	(	(	PUNCT
admet-2415	11	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2415	11	23	)	)	PUNCT
admet-2415	11	24	.	.	PUNCT
admet-2415	12	1	keywords	keyword	NOUN
admet-2415	12	2	murine	murine	VERB
admet-2415	12	3	tumor	tumor	NOUN
admet-2415	12	4	model	model	NOUN
admet-2415	12	5	;	;	PUNCT
admet-2415	12	6	pharmacokinetic	pharmacokinetic	ADJ
admet-2415	12	7	modeling	modeling	NOUN
admet-2415	12	8	;	;	PUNCT
admet-2415	12	9	tumor	tumor	NOUN
admet-2415	12	10	accumulation	accumulation	NOUN
admet-2415	12	11	;	;	PUNCT
admet-2415	12	12	biodistribution	biodistribution	NOUN
admet-2415	12	13	;	;	PUNCT
admet-2415	12	14	clinical	clinical	ADJ
admet-2415	12	15	trial	trial	NOUN
admet-2415	12	16	introduction	introduction	NOUN
admet-2415	12	17	over	over	ADP
admet-2415	12	18	the	the	DET
admet-2415	12	19	last	last	ADJ
admet-2415	12	20	two	two	NUM
admet-2415	12	21	decades	decade	NOUN
admet-2415	12	22	,	,	PUNCT
admet-2415	12	23	various	various	ADJ
admet-2415	12	24	nanoconstructs	nanoconstruct	NOUN
admet-2415	12	25	of	of	ADP
admet-2415	12	26	chemotherapeutic	chemotherapeutic	ADJ
admet-2415	12	27	agents	agent	NOUN
admet-2415	12	28	have	have	AUX
admet-2415	12	29	been	be	AUX
admet-2415	12	30	fabricated	fabricate	VERB
admet-2415	12	31	and	and	CCONJ
admet-2415	12	32	tested	test	VERB
admet-2415	12	33	in	in	ADP
admet-2415	12	34	tumor	tumor	NOUN
admet-2415	12	35	-	-	PUNCT
admet-2415	12	36	bearing	bear	VERB
admet-2415	12	37	mice	mouse	NOUN
admet-2415	12	38	.	.	PUNCT
admet-2415	13	1	in	in	ADP
admet-2415	13	2	these	these	DET
admet-2415	13	3	systems	system	NOUN
admet-2415	13	4	,	,	PUNCT
admet-2415	13	5	drug	drug	NOUN
admet-2415	13	6	molecules	molecule	NOUN
admet-2415	13	7	are	be	AUX
admet-2415	13	8	typically	typically	ADV
admet-2415	13	9	dispersed	disperse	VERB
admet-2415	13	10	and	and	CCONJ
admet-2415	13	11	encapsulated	encapsulate	VERB
admet-2415	13	12	by	by	ADP
admet-2415	13	13	polymeric	polymeric	ADJ
admet-2415	13	14	materials	material	NOUN
admet-2415	13	15	such	such	ADJ
admet-2415	13	16	as	as	ADP
admet-2415	13	17	so	so	ADV
admet-2415	13	18	-	-	PUNCT
admet-2415	13	19	called	call	VERB
admet-2415	13	20	nanoparticles	nanoparticle	NOUN
admet-2415	13	21	,	,	PUNCT
admet-2415	13	22	often	often	ADV
admet-2415	13	23	decorated	decorate	VERB
admet-2415	13	24	physically	physically	ADV
admet-2415	13	25	or	or	CCONJ
admet-2415	13	26	chemically	chemically	ADV
admet-2415	13	27	with	with	ADP
admet-2415	13	28	ligands	ligand	NOUN
admet-2415	13	29	aimed	aim	VERB
admet-2415	13	30	to	to	PART
admet-2415	13	31	bind	bind	VERB
admet-2415	13	32	to	to	ADP
admet-2415	13	33	receptors	receptor	NOUN
admet-2415	13	34	overexpressed	overexpresse	VERB
admet-2415	13	35	on	on	ADP
admet-2415	13	36	tumor	tumor	NOUN
admet-2415	13	37	cells	cell	NOUN
admet-2415	13	38	and	and	CCONJ
admet-2415	13	39	subsequently	subsequently	ADV
admet-2415	13	40	reduce	reduce	VERB
admet-2415	13	41	systemic	systemic	ADJ
admet-2415	13	42	toxicity	toxicity	NOUN
admet-2415	13	43	.	.	PUNCT
admet-2415	14	1	most	most	ADJ
admet-2415	14	2	novel	novel	ADJ
admet-2415	14	3	designs	design	NOUN
admet-2415	14	4	of	of	ADP
admet-2415	14	5	nanoparticles	nanoparticle	NOUN
admet-2415	14	6	,	,	PUNCT
admet-2415	14	7	however	however	ADV
admet-2415	14	8	,	,	PUNCT
admet-2415	14	9	have	have	AUX
admet-2415	14	10	not	not	PART
admet-2415	14	11	led	lead	VERB
admet-2415	14	12	to	to	ADP
admet-2415	14	13	a	a	DET
admet-2415	14	14	satisfactory	satisfactory	ADJ
admet-2415	14	15	return	return	NOUN
admet-2415	14	16	in	in	ADP
admet-2415	14	17	clinical	clinical	ADJ
admet-2415	14	18	applications	application	NOUN
admet-2415	14	19	commensurate	commensurate	ADJ
admet-2415	14	20	with	with	ADP
admet-2415	14	21	the	the	DET
admet-2415	14	22	extensive	extensive	ADJ
admet-2415	14	23	efforts	effort	NOUN
admet-2415	14	24	,	,	PUNCT
admet-2415	14	25	manpower	manpower	NOUN
admet-2415	14	26	,	,	PUNCT
admet-2415	14	27	and	and	CCONJ
admet-2415	14	28	research	research	NOUN
admet-2415	14	29	funding	funding	NOUN
admet-2415	14	30	invested	invest	VERB
admet-2415	14	31	[	[	X
admet-2415	14	32	1,2	1,2	NUM
admet-2415	14	33	]	]	PUNCT
admet-2415	14	34	.	.	PUNCT
admet-2415	15	1	the	the	DET
admet-2415	15	2	impetus	impetus	NOUN
admet-2415	15	3	for	for	ADP
admet-2415	15	4	nanoparticle	nanoparticle	NOUN
admet-2415	15	5	-	-	PUNCT
admet-2415	15	6	based	base	VERB
admet-2415	15	7	cancer	cancer	NOUN
admet-2415	15	8	therapies	therapy	NOUN
admet-2415	15	9	has	have	AUX
admet-2415	15	10	been	be	AUX
admet-2415	15	11	rooted	root	VERB
admet-2415	15	12	in	in	ADP
admet-2415	15	13	the	the	DET
admet-2415	15	14	concept	concept	NOUN
admet-2415	15	15	of	of	ADP
admet-2415	15	16	enhanced	enhanced	ADJ
admet-2415	15	17	permeation	permeation	NOUN
admet-2415	15	18	and	and	CCONJ
admet-2415	15	19	retention	retention	NOUN
admet-2415	15	20	(	(	PUNCT
admet-2415	15	21	epr	epr	ADJ
admet-2415	15	22	)	)	PUNCT
admet-2415	15	23	effect	effect	NOUN
admet-2415	15	24	,	,	PUNCT
admet-2415	15	25	which	which	PRON
admet-2415	15	26	states	state	VERB
admet-2415	15	27	that	that	SCONJ
admet-2415	15	28	vasculatures	vasculature	NOUN
admet-2415	15	29	in	in	ADP
admet-2415	15	30	a	a	DET
admet-2415	15	31	solid	solid	ADJ
admet-2415	15	32	tumor	tumor	NOUN
admet-2415	15	33	are	be	AUX
admet-2415	15	34	“	"	PUNCT
admet-2415	15	35	leaky	leaky	ADJ
admet-2415	15	36	,	,	PUNCT
admet-2415	15	37	”	"	PUNCT
admet-2415	15	38	allowing	allow	VERB
admet-2415	15	39	the	the	DET
admet-2415	15	40	preferred	preferred	ADJ
admet-2415	15	41	accumulation	accumulation	NOUN
admet-2415	15	42	of	of	ADP
admet-2415	15	43	nanoparticles	nanoparticle	NOUN
admet-2415	15	44	in	in	ADP
admet-2415	15	45	the	the	DET
admet-2415	15	46	tumor	tumor	NOUN
admet-2415	16	1	[	[	X
admet-2415	16	2	3	3	NUM
admet-2415	16	3	-	-	SYM
admet-2415	16	4	5	5	NUM
admet-2415	16	5	]	]	PUNCT
admet-2415	16	6	.	.	PUNCT
admet-2415	17	1	underdeveloped	underdeveloped	ADJ
admet-2415	17	2	lymphatic	lymphatic	ADJ
admet-2415	17	3	structures	structure	NOUN
admet-2415	17	4	and	and	CCONJ
admet-2415	17	5	lack	lack	NOUN
admet-2415	17	6	of	of	ADP
admet-2415	17	7	fluid	fluid	ADJ
admet-2415	17	8	drainage	drainage	NOUN
admet-2415	17	9	further	far	ADV
admet-2415	17	10	signify	signify	VERB
admet-2415	17	11	this	this	DET
admet-2415	17	12	effect	effect	NOUN
admet-2415	17	13	.	.	PUNCT
admet-2415	18	1	the	the	DET
admet-2415	18	2	concept	concept	NOUN
admet-2415	18	3	has	have	AUX
admet-2415	18	4	led	lead	VERB
admet-2415	18	5	researchers	researcher	NOUN
admet-2415	18	6	to	to	PART
admet-2415	18	7	engineer	engineer	VERB
admet-2415	18	8	a	a	DET
admet-2415	18	9	myriad	myriad	NOUN
admet-2415	18	10	of	of	ADP
admet-2415	18	11	nanoparticle	nanoparticle	NOUN
admet-2415	18	12	designs	design	NOUN
admet-2415	18	13	exhibiting	exhibit	VERB
admet-2415	18	14	unique	unique	ADJ
admet-2415	18	15	physicochemical	physicochemical	ADJ
admet-2415	18	16	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	18	17	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	ADJ
admet-2415	18	18	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-2415	18	19	mailto:tonglei@purdue.edu	mailto:tonglei@purdue.edu	PROPN
admet-2415	19	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2415	19	2	s.	s.	PROPN
admet-2415	19	3	lu	lu	PROPN
admet-2415	19	4	et	et	PROPN
admet-2415	19	5	al	al	PROPN
admet-2415	19	6	.	.	PROPN
admet-2415	19	7	admet	admet	PROPN
admet-2415	19	8	&	&	CCONJ
admet-2415	19	9	dmpk	dmpk	PROPN
admet-2415	19	10	12(5	12(5	NUM
admet-2415	19	11	)	)	PUNCT
admet-2415	19	12	(	(	PUNCT
admet-2415	19	13	2024	2024	NUM
admet-2415	19	14	)	)	PUNCT
admet-2415	19	15	705	705	NUM
admet-2415	19	16	-	-	SYM
admet-2415	19	17	719	719	NUM
admet-2415	19	18	706	706	NUM
admet-2415	19	19	properties	property	NOUN
admet-2415	19	20	(	(	PUNCT
admet-2415	19	21	size	size	NOUN
admet-2415	19	22	,	,	PUNCT
admet-2415	19	23	shape	shape	NOUN
admet-2415	19	24	,	,	PUNCT
admet-2415	19	25	surface	surface	NOUN
admet-2415	19	26	chemistry	chemistry	NOUN
admet-2415	19	27	,	,	PUNCT
admet-2415	19	28	etc	etc	X
admet-2415	19	29	.	.	X
admet-2415	19	30	)	)	PUNCT
admet-2415	19	31	targeted	target	VERB
admet-2415	19	32	to	to	ADP
admet-2415	19	33	a	a	DET
admet-2415	19	34	multitude	multitude	NOUN
admet-2415	19	35	of	of	ADP
admet-2415	19	36	biological	biological	ADJ
admet-2415	19	37	and	and	CCONJ
admet-2415	19	38	pathological	pathological	ADJ
admet-2415	19	39	functions	function	NOUN
admet-2415	19	40	to	to	PART
admet-2415	19	41	improve	improve	VERB
admet-2415	19	42	drug	drug	NOUN
admet-2415	19	43	efficacy	efficacy	NOUN
admet-2415	19	44	[	[	X
admet-2415	19	45	2,6	2,6	NUM
admet-2415	19	46	]	]	PUNCT
admet-2415	19	47	.	.	PUNCT
admet-2415	20	1	while	while	SCONJ
admet-2415	20	2	the	the	DET
admet-2415	20	3	underlying	underlying	ADJ
admet-2415	20	4	role	role	NOUN
admet-2415	20	5	of	of	ADP
admet-2415	20	6	the	the	DET
admet-2415	20	7	nanoparticles	nanoparticle	NOUN
admet-2415	20	8	in	in	ADP
admet-2415	20	9	tumor	tumor	NOUN
admet-2415	20	10	targeting	target	VERB
admet-2415	20	11	has	have	AUX
admet-2415	20	12	been	be	AUX
admet-2415	20	13	argued	argue	VERB
admet-2415	20	14	from	from	ADP
admet-2415	20	15	both	both	DET
admet-2415	20	16	sides	side	NOUN
admet-2415	20	17	[	[	X
admet-2415	20	18	7,8	7,8	NUM
admet-2415	20	19	]	]	PUNCT
admet-2415	20	20	,	,	PUNCT
admet-2415	20	21	one	one	NUM
admet-2415	20	22	consensus	consensus	NOUN
admet-2415	20	23	among	among	ADP
admet-2415	20	24	researchers	researcher	NOUN
admet-2415	20	25	in	in	ADP
admet-2415	20	26	developing	develop	VERB
admet-2415	20	27	nanomedicines	nanomedicine	NOUN
admet-2415	20	28	is	be	AUX
admet-2415	20	29	that	that	SCONJ
admet-2415	20	30	further	further	ADJ
admet-2415	20	31	understanding	understanding	NOUN
admet-2415	20	32	of	of	ADP
admet-2415	20	33	in	in	ADP
admet-2415	20	34	vivo	vivo	ADJ
admet-2415	20	35	behaviors	behavior	NOUN
admet-2415	20	36	of	of	ADP
admet-2415	20	37	a	a	DET
admet-2415	20	38	nanoparticle	nanoparticle	NOUN
admet-2415	20	39	system	system	NOUN
admet-2415	20	40	,	,	PUNCT
admet-2415	20	41	including	include	VERB
admet-2415	20	42	interactions	interaction	NOUN
admet-2415	20	43	with	with	ADP
admet-2415	20	44	tissues	tissue	NOUN
admet-2415	20	45	and	and	CCONJ
admet-2415	20	46	cells	cell	NOUN
admet-2415	20	47	,	,	PUNCT
admet-2415	20	48	is	be	AUX
admet-2415	20	49	needed	need	VERB
admet-2415	20	50	.	.	PUNCT
admet-2415	21	1	such	such	ADJ
admet-2415	21	2	knowledge	knowledge	NOUN
admet-2415	21	3	of	of	ADP
admet-2415	21	4	drug	drug	NOUN
admet-2415	21	5	nanocrystals	nanocrystal	NOUN
admet-2415	21	6	is	be	AUX
admet-2415	21	7	scarce	scarce	ADJ
admet-2415	21	8	.	.	PUNCT
admet-2415	22	1	our	our	PRON
admet-2415	22	2	studies	study	NOUN
admet-2415	22	3	towards	towards	ADP
admet-2415	22	4	developing	develop	VERB
admet-2415	22	5	drug	drug	NOUN
admet-2415	22	6	nanocrystals	nanocrystal	NOUN
admet-2415	22	7	for	for	ADP
admet-2415	22	8	chemotherapy	chemotherapy	NOUN
admet-2415	22	9	are	be	AUX
admet-2415	22	10	built	build	VERB
admet-2415	22	11	upon	upon	SCONJ
admet-2415	22	12	the	the	DET
admet-2415	22	13	rationale	rationale	NOUN
admet-2415	22	14	that	that	SCONJ
admet-2415	22	15	a	a	DET
admet-2415	22	16	poorly	poorly	ADV
admet-2415	22	17	water	water	NOUN
admet-2415	22	18	-	-	PUNCT
admet-2415	22	19	soluble	soluble	ADJ
admet-2415	22	20	drug	drug	NOUN
admet-2415	22	21	can	can	AUX
admet-2415	22	22	be	be	AUX
admet-2415	22	23	delivered	deliver	VERB
admet-2415	22	24	intravenously	intravenously	ADV
admet-2415	22	25	(	(	PUNCT
admet-2415	22	26	iv	iv	X
admet-2415	22	27	)	)	PUNCT
admet-2415	22	28	directly	directly	ADV
admet-2415	22	29	as	as	ADP
admet-2415	22	30	solid	solid	ADJ
admet-2415	22	31	,	,	PUNCT
admet-2415	22	32	crystalline	crystalline	ADJ
admet-2415	22	33	particles	particle	NOUN
admet-2415	22	34	without	without	ADP
admet-2415	22	35	using	use	VERB
admet-2415	22	36	any	any	DET
admet-2415	22	37	solubilizing	solubilize	VERB
admet-2415	22	38	chemicals	chemical	NOUN
admet-2415	22	39	,	,	PUNCT
admet-2415	22	40	as	as	ADV
admet-2415	22	41	long	long	ADV
admet-2415	22	42	as	as	SCONJ
admet-2415	22	43	their	their	PRON
admet-2415	22	44	particle	particle	NOUN
admet-2415	22	45	size	size	NOUN
admet-2415	22	46	remains	remain	VERB
admet-2415	22	47	within	within	ADP
admet-2415	22	48	a	a	DET
admet-2415	22	49	few	few	ADJ
admet-2415	22	50	hundred	hundred	NUM
admet-2415	22	51	nanometers	nanometer	NOUN
admet-2415	22	52	[	[	PUNCT
admet-2415	22	53	9	9	NUM
admet-2415	22	54	-	-	SYM
admet-2415	22	55	15	15	NUM
admet-2415	22	56	]	]	PUNCT
admet-2415	22	57	.	.	PUNCT
admet-2415	23	1	uniformity	uniformity	NOUN
admet-2415	23	2	in	in	ADP
admet-2415	23	3	particle	particle	NOUN
admet-2415	23	4	size	size	NOUN
admet-2415	23	5	and	and	CCONJ
admet-2415	23	6	morphology	morphology	NOUN
admet-2415	23	7	is	be	AUX
admet-2415	23	8	therefore	therefore	ADV
admet-2415	23	9	crucial	crucial	ADJ
admet-2415	23	10	in	in	ADP
admet-2415	23	11	maintaining	maintain	VERB
admet-2415	23	12	physical	physical	ADJ
admet-2415	23	13	stabilities	stability	NOUN
admet-2415	23	14	and	and	CCONJ
admet-2415	23	15	ensuring	ensure	VERB
admet-2415	23	16	predictable	predictable	ADJ
admet-2415	23	17	drug	drug	NOUN
admet-2415	23	18	release	release	NOUN
admet-2415	23	19	kinetics	kinetic	NOUN
admet-2415	23	20	.	.	PUNCT
admet-2415	24	1	surface	surface	NOUN
admet-2415	24	2	treatment	treatment	NOUN
admet-2415	24	3	of	of	ADP
admet-2415	24	4	drug	drug	NOUN
admet-2415	24	5	nanocrystals	nanocrystal	NOUN
admet-2415	24	6	may	may	AUX
admet-2415	24	7	be	be	AUX
admet-2415	24	8	desired	desire	VERB
admet-2415	24	9	by	by	ADP
admet-2415	24	10	the	the	DET
admet-2415	24	11	physical	physical	ADJ
admet-2415	24	12	adhesion	adhesion	NOUN
admet-2415	24	13	of	of	ADP
admet-2415	24	14	polymeric	polymeric	ADJ
admet-2415	24	15	surfactants	surfactant	NOUN
admet-2415	24	16	to	to	PART
admet-2415	24	17	prolong	prolong	VERB
admet-2415	24	18	systemic	systemic	ADJ
admet-2415	24	19	circulation	circulation	NOUN
admet-2415	24	20	.	.	PUNCT
admet-2415	25	1	nanocrystals	nanocrystal	NOUN
admet-2415	25	2	are	be	AUX
admet-2415	25	3	physically	physically	ADV
admet-2415	25	4	more	more	ADV
admet-2415	25	5	stable	stable	ADJ
admet-2415	25	6	than	than	ADP
admet-2415	25	7	other	other	ADJ
admet-2415	25	8	nanoparticle	nanoparticle	NOUN
admet-2415	25	9	formulations	formulation	NOUN
admet-2415	25	10	and	and	CCONJ
admet-2415	25	11	can	can	AUX
admet-2415	25	12	achieve	achieve	VERB
admet-2415	25	13	nearly	nearly	ADV
admet-2415	25	14	100	100	NUM
admet-2415	25	15	%	%	NOUN
admet-2415	25	16	drug	drug	NOUN
admet-2415	25	17	loading	loading	NOUN
admet-2415	25	18	.	.	PUNCT
admet-2415	26	1	we	we	PRON
admet-2415	26	2	have	have	AUX
admet-2415	26	3	mainly	mainly	ADV
admet-2415	26	4	focused	focus	VERB
admet-2415	26	5	on	on	ADP
admet-2415	26	6	testing	test	VERB
admet-2415	26	7	bare	bare	ADJ
admet-2415	26	8	and	and	CCONJ
admet-2415	26	9	surface	surface	NOUN
admet-2415	26	10	-	-	PUNCT
admet-2415	26	11	treated	treat	VERB
admet-2415	26	12	paclitaxel	paclitaxel	PROPN
admet-2415	26	13	(	(	PUNCT
admet-2415	26	14	ptx	ptx	NOUN
admet-2415	26	15	)	)	PUNCT
admet-2415	26	16	nanocrystals	nanocrystal	NOUN
admet-2415	26	17	in	in	ADP
admet-2415	26	18	murine	murine	ADJ
admet-2415	26	19	tumor	tumor	NOUN
admet-2415	26	20	models	model	NOUN
admet-2415	26	21	[	[	X
admet-2415	26	22	10,11	10,11	NOUN
admet-2415	26	23	]	]	PUNCT
admet-2415	26	24	.	.	PUNCT
admet-2415	27	1	in	in	ADP
admet-2415	27	2	these	these	DET
admet-2415	27	3	studies	study	NOUN
admet-2415	27	4	,	,	PUNCT
admet-2415	27	5	biodistribution	biodistribution	NOUN
admet-2415	27	6	and	and	CCONJ
admet-2415	27	7	pharmacokinetics	pharmacokinetic	NOUN
admet-2415	27	8	(	(	PUNCT
admet-2415	27	9	pk	pk	NOUN
admet-2415	27	10	)	)	PUNCT
admet-2415	27	11	were	be	AUX
admet-2415	27	12	determined	determine	VERB
admet-2415	27	13	by	by	ADP
admet-2415	27	14	measuring	measure	VERB
admet-2415	27	15	drug	drug	NOUN
admet-2415	27	16	concentrations	concentration	NOUN
admet-2415	27	17	in	in	ADP
admet-2415	27	18	blood	blood	NOUN
admet-2415	27	19	and	and	CCONJ
admet-2415	27	20	major	major	ADJ
admet-2415	27	21	organs	organ	NOUN
admet-2415	27	22	(	(	PUNCT
admet-2415	27	23	including	include	VERB
admet-2415	27	24	liver	liver	NOUN
admet-2415	27	25	,	,	PUNCT
admet-2415	27	26	heart	heart	NOUN
admet-2415	27	27	,	,	PUNCT
admet-2415	27	28	lung	lung	NOUN
admet-2415	27	29	,	,	PUNCT
admet-2415	27	30	spleen	spleen	NOUN
admet-2415	27	31	,	,	PUNCT
admet-2415	27	32	and	and	CCONJ
admet-2415	27	33	kidney	kidney	NOUN
admet-2415	27	34	)	)	PUNCT
admet-2415	27	35	and	and	CCONJ
admet-2415	27	36	in	in	ADP
admet-2415	27	37	tumor	tumor	NOUN
admet-2415	27	38	.	.	PUNCT
admet-2415	28	1	antitumor	antitumor	PROPN
admet-2415	28	2	efficacy	efficacy	NOUN
admet-2415	28	3	and	and	CCONJ
admet-2415	28	4	treatment	treatment	NOUN
admet-2415	28	5	toxicity	toxicity	NOUN
admet-2415	28	6	were	be	AUX
admet-2415	28	7	evaluated	evaluate	VERB
admet-2415	28	8	by	by	ADP
admet-2415	28	9	monitoring	monitor	VERB
admet-2415	28	10	tumor	tumor	NOUN
admet-2415	28	11	volume	volume	NOUN
admet-2415	28	12	,	,	PUNCT
admet-2415	28	13	body	body	NOUN
admet-2415	28	14	weight	weight	NOUN
admet-2415	28	15	,	,	PUNCT
admet-2415	28	16	and	and	CCONJ
admet-2415	28	17	overall	overall	ADJ
admet-2415	28	18	morbidity	morbidity	NOUN
admet-2415	28	19	and	and	CCONJ
admet-2415	28	20	compared	compare	VERB
admet-2415	28	21	to	to	ADP
admet-2415	28	22	results	result	NOUN
admet-2415	28	23	of	of	ADP
admet-2415	28	24	murine	murine	ADJ
admet-2415	28	25	tumor	tumor	NOUN
admet-2415	28	26	models	model	NOUN
admet-2415	28	27	treated	treat	VERB
admet-2415	28	28	with	with	ADP
admet-2415	28	29	conventional	conventional	ADJ
admet-2415	28	30	formulations	formulation	NOUN
admet-2415	28	31	(	(	PUNCT
admet-2415	28	32	i.e.	i.e.	X
admet-2415	28	33	taxol	taxol	NOUN
admet-2415	28	34	)	)	PUNCT
admet-2415	28	35	.	.	PUNCT
admet-2415	29	1	our	our	PRON
admet-2415	29	2	results	result	NOUN
admet-2415	29	3	indicate	indicate	VERB
admet-2415	29	4	that	that	SCONJ
admet-2415	29	5	the	the	DET
admet-2415	29	6	ptx	ptx	NOUN
admet-2415	29	7	nanocrystals	nanocrystal	NOUN
admet-2415	29	8	physically	physically	ADV
admet-2415	29	9	treated	treat	VERB
admet-2415	29	10	by	by	ADP
admet-2415	29	11	pluronic	pluronic	ADJ
admet-2415	29	12	®	®	NOUN
admet-2415	29	13	f-68	f-68	NOUN
admet-2415	29	14	(	(	PUNCT
admet-2415	29	15	triblock	triblock	NOUN
admet-2415	29	16	copolymer	copolymer	NOUN
admet-2415	29	17	of	of	ADP
admet-2415	29	18	poly(ethylene	poly(ethylene	ADJ
admet-2415	29	19	glycol	glycol	NOUN
admet-2415	29	20	)	)	PUNCT
admet-2415	29	21	,	,	PUNCT
admet-2415	29	22	peg	peg	NOUN
admet-2415	29	23	,	,	PUNCT
admet-2415	29	24	and	and	CCONJ
admet-2415	29	25	poly(propylene	poly(propylene	VERB
admet-2415	29	26	glycol	glycol	NOUN
admet-2415	29	27	)	)	PUNCT
admet-2415	29	28	,	,	PUNCT
admet-2415	29	29	ppg	ppg	PROPN
admet-2415	29	30	)	)	PUNCT
admet-2415	29	31	achieved	achieve	VERB
admet-2415	29	32	higher	high	ADJ
admet-2415	29	33	efficacy	efficacy	NOUN
admet-2415	29	34	toward	toward	ADP
admet-2415	29	35	tumor	tumor	NOUN
admet-2415	29	36	growth	growth	NOUN
admet-2415	29	37	inhibition	inhibition	NOUN
admet-2415	29	38	and	and	CCONJ
admet-2415	29	39	more	more	ADV
admet-2415	29	40	significant	significant	ADJ
admet-2415	29	41	drug	drug	NOUN
admet-2415	29	42	accumulation	accumulation	NOUN
admet-2415	29	43	in	in	ADP
admet-2415	29	44	the	the	DET
admet-2415	29	45	tumor	tumor	NOUN
admet-2415	29	46	than	than	ADP
admet-2415	29	47	bare	bare	ADJ
admet-2415	29	48	ptx	ptx	NOUN
admet-2415	29	49	ncs	ncs	NOUN
admet-2415	29	50	[	[	X
admet-2415	29	51	11	11	NUM
admet-2415	29	52	]	]	PUNCT
admet-2415	29	53	.	.	PUNCT
admet-2415	30	1	loss	loss	NOUN
admet-2415	30	2	in	in	ADP
admet-2415	30	3	body	body	NOUN
admet-2415	30	4	weight	weight	NOUN
admet-2415	30	5	was	be	AUX
admet-2415	30	6	generally	generally	ADV
admet-2415	30	7	lower	low	ADJ
admet-2415	30	8	in	in	ADP
admet-2415	30	9	the	the	DET
admet-2415	30	10	nanocrystal	nanocrystal	ADV
admet-2415	30	11	-	-	PUNCT
admet-2415	30	12	treated	treat	VERB
admet-2415	30	13	mice	mouse	NOUN
admet-2415	30	14	than	than	ADP
admet-2415	30	15	in	in	ADP
admet-2415	30	16	the	the	DET
admet-2415	30	17	taxol	taxol	NOUN
admet-2415	30	18	-	-	PUNCT
admet-2415	30	19	treated	treat	VERB
admet-2415	30	20	group	group	NOUN
admet-2415	30	21	,	,	PUNCT
admet-2415	30	22	indicating	indicate	VERB
admet-2415	30	23	less	less	ADJ
admet-2415	30	24	systemic	systemic	ADJ
admet-2415	30	25	toxicity	toxicity	NOUN
admet-2415	30	26	elicited	elicit	VERB
admet-2415	30	27	by	by	ADP
admet-2415	30	28	the	the	DET
admet-2415	30	29	nanocrystals	nanocrystal	NOUN
admet-2415	30	30	[	[	X
admet-2415	30	31	10,11	10,11	NOUN
admet-2415	30	32	]	]	PUNCT
admet-2415	30	33	.	.	PUNCT
admet-2415	31	1	while	while	SCONJ
admet-2415	31	2	the	the	DET
admet-2415	31	3	drug	drug	NOUN
admet-2415	31	4	of	of	ADP
admet-2415	31	5	taxol	taxol	PROPN
admet-2415	31	6	was	be	AUX
admet-2415	31	7	distributed	distribute	VERB
admet-2415	31	8	extensively	extensively	ADV
admet-2415	31	9	to	to	ADP
admet-2415	31	10	all	all	DET
admet-2415	31	11	major	major	ADJ
admet-2415	31	12	organs	organ	NOUN
admet-2415	31	13	upon	upon	SCONJ
admet-2415	31	14	iv	iv	NUM
admet-2415	31	15	administration	administration	NOUN
admet-2415	31	16	,	,	PUNCT
admet-2415	31	17	ncs	ncs	PROPN
admet-2415	31	18	were	be	AUX
admet-2415	31	19	cleared	clear	VERB
admet-2415	31	20	rapidly	rapidly	ADV
admet-2415	31	21	from	from	ADP
admet-2415	31	22	the	the	DET
admet-2415	31	23	blood	blood	NOUN
admet-2415	31	24	circulation	circulation	NOUN
admet-2415	31	25	and	and	CCONJ
admet-2415	31	26	primarily	primarily	ADV
admet-2415	31	27	taken	take	VERB
admet-2415	31	28	up	up	ADP
admet-2415	31	29	by	by	ADP
admet-2415	31	30	the	the	DET
admet-2415	31	31	liver	liver	NOUN
admet-2415	31	32	,	,	PUNCT
admet-2415	31	33	spleen	spleen	NOUN
admet-2415	31	34	,	,	PUNCT
admet-2415	31	35	and	and	CCONJ
admet-2415	31	36	lungs	lung	NOUN
admet-2415	31	37	because	because	SCONJ
admet-2415	31	38	of	of	ADP
admet-2415	31	39	phagocytic	phagocytic	ADJ
admet-2415	31	40	sequestration	sequestration	NOUN
admet-2415	31	41	.	.	PUNCT
admet-2415	32	1	the	the	DET
admet-2415	32	2	f-68	f-68	ADV
admet-2415	32	3	treated	treat	VERB
admet-2415	32	4	ncs	ncs	NOUN
admet-2415	32	5	showed	show	VERB
admet-2415	32	6	less	less	ADV
admet-2415	32	7	uptake	uptake	ADJ
admet-2415	32	8	by	by	ADP
admet-2415	32	9	the	the	DET
admet-2415	32	10	liver	liver	NOUN
admet-2415	32	11	than	than	ADP
admet-2415	32	12	bare	bare	ADJ
admet-2415	32	13	ncs	nc	NOUN
admet-2415	32	14	,	,	PUNCT
admet-2415	32	15	though	though	SCONJ
admet-2415	32	16	this	this	PRON
admet-2415	32	17	was	be	AUX
admet-2415	32	18	still	still	ADV
admet-2415	32	19	significant	significant	ADJ
admet-2415	32	20	compared	compare	VERB
admet-2415	32	21	to	to	ADP
admet-2415	32	22	taxol	taxol	PROPN
admet-2415	32	23	.	.	PUNCT
admet-2415	33	1	moreover	moreover	ADV
admet-2415	33	2	,	,	PUNCT
admet-2415	33	3	surface	surface	NOUN
admet-2415	33	4	-	-	PUNCT
admet-2415	33	5	treated	treat	VERB
admet-2415	33	6	nc	nc	NOUN
admet-2415	33	7	accumulated	accumulate	VERB
admet-2415	33	8	more	more	ADV
admet-2415	33	9	in	in	ADP
admet-2415	33	10	the	the	DET
admet-2415	33	11	tumor	tumor	NOUN
admet-2415	33	12	than	than	ADP
admet-2415	33	13	bare	bare	ADJ
admet-2415	33	14	nc	nc	PROPN
admet-2415	33	15	(	(	PUNCT
admet-2415	33	16	2	2	NUM
admet-2415	33	17	vs.	vs.	ADP
admet-2415	33	18	1	1	NUM
admet-2415	33	19	%	%	NOUN
admet-2415	33	20	of	of	ADP
admet-2415	33	21	injected	inject	VERB
admet-2415	33	22	dose	dose	NOUN
admet-2415	33	23	,	,	PUNCT
admet-2415	33	24	respectively	respectively	ADV
admet-2415	33	25	)	)	PUNCT
admet-2415	33	26	.	.	PUNCT
admet-2415	34	1	the	the	DET
admet-2415	34	2	finding	finding	NOUN
admet-2415	34	3	suggests	suggest	VERB
admet-2415	34	4	that	that	SCONJ
admet-2415	34	5	the	the	DET
admet-2415	34	6	drastic	drastic	ADJ
admet-2415	34	7	increase	increase	NOUN
admet-2415	34	8	in	in	ADP
admet-2415	34	9	tumor	tumor	NOUN
admet-2415	34	10	accumulation	accumulation	NOUN
admet-2415	34	11	of	of	ADP
admet-2415	34	12	a	a	DET
admet-2415	34	13	nanoparticle	nanoparticle	NOUN
admet-2415	34	14	delivery	delivery	NOUN
admet-2415	34	15	system	system	NOUN
admet-2415	34	16	,	,	PUNCT
admet-2415	34	17	possibly	possibly	ADV
admet-2415	34	18	due	due	ADP
admet-2415	34	19	to	to	ADP
admet-2415	34	20	the	the	DET
admet-2415	34	21	epr	epr	PROPN
admet-2415	34	22	effect	effect	NOUN
admet-2415	34	23	,	,	PUNCT
admet-2415	34	24	is	be	AUX
admet-2415	34	25	not	not	PART
admet-2415	34	26	seen	see	VERB
admet-2415	34	27	in	in	ADP
admet-2415	34	28	the	the	DET
admet-2415	34	29	animal	animal	NOUN
admet-2415	34	30	models	model	NOUN
admet-2415	34	31	,	,	PUNCT
admet-2415	34	32	seemingly	seemingly	ADV
admet-2415	34	33	in	in	ADP
admet-2415	34	34	agreement	agreement	NOUN
admet-2415	34	35	with	with	ADP
admet-2415	34	36	other	other	ADJ
admet-2415	34	37	nanosystems	nanosystem	NOUN
admet-2415	34	38	[	[	X
admet-2415	34	39	2	2	NUM
admet-2415	34	40	]	]	PUNCT
admet-2415	34	41	.	.	PUNCT
admet-2415	35	1	furthermore	furthermore	ADV
admet-2415	35	2	,	,	PUNCT
admet-2415	35	3	the	the	DET
admet-2415	35	4	tumor	tumor	NOUN
admet-2415	35	5	accumulation	accumulation	NOUN
admet-2415	35	6	of	of	ADP
admet-2415	35	7	taxol	taxol	PROPN
admet-2415	35	8	was	be	AUX
admet-2415	35	9	on	on	ADP
admet-2415	35	10	par	par	NOUN
admet-2415	35	11	with	with	ADP
admet-2415	35	12	the	the	DET
admet-2415	35	13	ncs	ncs	NOUN
admet-2415	35	14	,	,	PUNCT
admet-2415	35	15	possibly	possibly	ADV
admet-2415	35	16	due	due	ADP
admet-2415	35	17	to	to	ADP
admet-2415	35	18	micellization	micellization	NOUN
admet-2415	35	19	of	of	ADP
admet-2415	35	20	the	the	DET
admet-2415	35	21	drug	drug	NOUN
admet-2415	35	22	,	,	PUNCT
admet-2415	35	23	despite	despite	SCONJ
admet-2415	35	24	its	its	PRON
admet-2415	35	25	biodistribution	biodistribution	NOUN
admet-2415	35	26	being	be	AUX
admet-2415	35	27	completely	completely	ADV
admet-2415	35	28	different	different	ADJ
admet-2415	35	29	[	[	X
admet-2415	35	30	16	16	NUM
admet-2415	35	31	]	]	PUNCT
admet-2415	35	32	.	.	PUNCT
admet-2415	36	1	these	these	DET
admet-2415	36	2	studies	study	NOUN
admet-2415	36	3	raise	raise	VERB
admet-2415	36	4	an	an	DET
admet-2415	36	5	interesting	interesting	ADJ
admet-2415	36	6	and	and	CCONJ
admet-2415	36	7	fundamental	fundamental	ADJ
admet-2415	36	8	question	question	NOUN
admet-2415	36	9	of	of	ADP
admet-2415	36	10	what	what	PRON
admet-2415	36	11	factors	factor	NOUN
admet-2415	36	12	determine	determine	VERB
admet-2415	36	13	the	the	DET
admet-2415	36	14	tissue	tissue	NOUN
admet-2415	36	15	distribution	distribution	NOUN
admet-2415	36	16	and	and	CCONJ
admet-2415	36	17	tumor	tumor	NOUN
admet-2415	36	18	accumulation	accumulation	NOUN
admet-2415	36	19	of	of	ADP
admet-2415	36	20	a	a	DET
admet-2415	36	21	nanoparticle	nanoparticle	NOUN
admet-2415	36	22	delivery	delivery	NOUN
admet-2415	36	23	system	system	NOUN
admet-2415	36	24	.	.	PUNCT
admet-2415	37	1	the	the	DET
admet-2415	37	2	particle	particle	NOUN
admet-2415	37	3	size	size	NOUN
admet-2415	37	4	and	and	CCONJ
admet-2415	37	5	surface	surface	NOUN
admet-2415	37	6	chemistry	chemistry	NOUN
admet-2415	37	7	of	of	ADP
admet-2415	37	8	a	a	DET
admet-2415	37	9	nanoparticle	nanoparticle	NOUN
admet-2415	37	10	-	-	PUNCT
admet-2415	37	11	based	base	VERB
admet-2415	37	12	delivery	delivery	NOUN
admet-2415	37	13	system	system	NOUN
admet-2415	37	14	affect	affect	VERB
admet-2415	37	15	pk	pk	NOUN
admet-2415	37	16	behaviors	behavior	NOUN
admet-2415	37	17	,	,	PUNCT
admet-2415	37	18	but	but	CCONJ
admet-2415	37	19	mechanistic	mechanistic	ADJ
admet-2415	37	20	interactions	interaction	NOUN
admet-2415	37	21	between	between	ADP
admet-2415	37	22	nanoparticles	nanoparticle	NOUN
admet-2415	37	23	and	and	CCONJ
admet-2415	37	24	biological	biological	ADJ
admet-2415	37	25	systems	system	NOUN
admet-2415	37	26	remain	remain	VERB
admet-2415	37	27	less	less	ADV
admet-2415	37	28	studied	studied	ADJ
admet-2415	37	29	.	.	PUNCT
admet-2415	38	1	in	in	ADP
admet-2415	38	2	particular	particular	ADJ
admet-2415	38	3	,	,	PUNCT
admet-2415	38	4	little	little	ADJ
admet-2415	38	5	is	be	AUX
admet-2415	38	6	known	know	VERB
admet-2415	38	7	about	about	ADP
admet-2415	38	8	the	the	DET
admet-2415	38	9	in	in	ADP
admet-2415	38	10	vivo	vivo	ADJ
admet-2415	38	11	fate	fate	NOUN
admet-2415	38	12	of	of	ADP
admet-2415	38	13	drug	drug	NOUN
admet-2415	38	14	nanocrystals	nanocrystal	NOUN
admet-2415	38	15	,	,	PUNCT
admet-2415	38	16	which	which	PRON
admet-2415	38	17	is	be	AUX
admet-2415	38	18	complicated	complicate	VERB
admet-2415	38	19	by	by	ADP
admet-2415	38	20	the	the	DET
admet-2415	38	21	dynamic	dynamic	ADJ
admet-2415	38	22	dissolution	dissolution	NOUN
admet-2415	38	23	process	process	NOUN
admet-2415	38	24	of	of	ADP
admet-2415	38	25	solid	solid	ADJ
admet-2415	38	26	particles	particle	NOUN
admet-2415	38	27	and	and	CCONJ
admet-2415	38	28	the	the	DET
admet-2415	38	29	release	release	NOUN
admet-2415	38	30	of	of	ADP
admet-2415	38	31	free	free	ADJ
admet-2415	38	32	drug	drug	NOUN
admet-2415	38	33	molecules	molecule	NOUN
admet-2415	38	34	.	.	PUNCT
admet-2415	39	1	in	in	ADP
admet-2415	39	2	the	the	DET
admet-2415	39	3	current	current	ADJ
admet-2415	39	4	study	study	NOUN
admet-2415	39	5	,	,	PUNCT
admet-2415	39	6	we	we	PRON
admet-2415	39	7	attempted	attempt	VERB
admet-2415	39	8	to	to	PART
admet-2415	39	9	conduct	conduct	VERB
admet-2415	39	10	pk	pk	NOUN
admet-2415	39	11	modeling	modeling	NOUN
admet-2415	39	12	with	with	ADP
admet-2415	39	13	a	a	DET
admet-2415	39	14	physiologically	physiologically	ADV
admet-2415	39	15	based	base	VERB
admet-2415	39	16	pharmacokinetics	pharmacokinetic	NOUN
admet-2415	39	17	(	(	PUNCT
admet-2415	39	18	pbpk	pbpk	ADJ
admet-2415	39	19	)	)	PUNCT
admet-2415	39	20	method	method	NOUN
admet-2415	39	21	,	,	PUNCT
admet-2415	39	22	coupled	couple	VERB
admet-2415	39	23	with	with	ADP
admet-2415	39	24	pharmacodynamics	pharmacodynamic	NOUN
admet-2415	39	25	(	(	PUNCT
admet-2415	39	26	pd	pd	NOUN
admet-2415	39	27	)	)	PUNCT
admet-2415	39	28	simulations	simulation	NOUN
admet-2415	39	29	,	,	PUNCT
admet-2415	39	30	to	to	PART
admet-2415	39	31	explore	explore	VERB
admet-2415	39	32	possible	possible	ADJ
admet-2415	39	33	factors	factor	NOUN
admet-2415	39	34	determining	determine	VERB
admet-2415	39	35	drug	drug	NOUN
admet-2415	39	36	nanocrystals	nanocrystal	NOUN
admet-2415	39	37	'	'	PART
admet-2415	39	38	biodistribution	biodistribution	NOUN
admet-2415	39	39	and	and	CCONJ
admet-2415	39	40	treatment	treatment	NOUN
admet-2415	39	41	efficacy	efficacy	NOUN
admet-2415	39	42	.	.	PUNCT
admet-2415	40	1	by	by	ADP
admet-2415	40	2	fitting	fit	VERB
admet-2415	40	3	these	these	DET
admet-2415	40	4	models	model	NOUN
admet-2415	40	5	to	to	ADP
admet-2415	40	6	our	our	PRON
admet-2415	40	7	in	in	ADP
admet-2415	40	8	vivo	vivo	ADJ
admet-2415	40	9	data	datum	NOUN
admet-2415	40	10	obtained	obtain	VERB
admet-2415	40	11	in	in	ADP
admet-2415	40	12	animals	animal	NOUN
admet-2415	40	13	,	,	PUNCT
admet-2415	40	14	it	it	PRON
admet-2415	40	15	is	be	AUX
admet-2415	40	16	possible	possible	ADJ
admet-2415	40	17	to	to	PART
admet-2415	40	18	delineate	delineate	VERB
admet-2415	40	19	various	various	ADJ
admet-2415	40	20	factors	factor	NOUN
admet-2415	40	21	on	on	ADP
admet-2415	40	22	transport	transport	NOUN
admet-2415	40	23	kinetics	kinetic	NOUN
admet-2415	40	24	and	and	CCONJ
admet-2415	40	25	in	in	ADP
admet-2415	40	26	vivo	vivo	ADJ
admet-2415	40	27	performance	performance	NOUN
admet-2415	40	28	.	.	PUNCT
admet-2415	41	1	the	the	DET
admet-2415	41	2	pbpk	pbpk	PROPN
admet-2415	41	3	model	model	NOUN
admet-2415	41	4	has	have	AUX
admet-2415	41	5	been	be	AUX
admet-2415	41	6	established	establish	VERB
admet-2415	41	7	as	as	ADP
admet-2415	41	8	a	a	DET
admet-2415	41	9	prediction	prediction	NOUN
admet-2415	41	10	framework	framework	NOUN
admet-2415	41	11	for	for	ADP
admet-2415	41	12	quantitatively	quantitatively	ADV
admet-2415	41	13	describing	describe	VERB
admet-2415	41	14	drug	drug	NOUN
admet-2415	41	15	absorption	absorption	NOUN
admet-2415	41	16	,	,	PUNCT
admet-2415	41	17	distribution	distribution	NOUN
admet-2415	41	18	,	,	PUNCT
admet-2415	41	19	metabolism	metabolism	NOUN
admet-2415	41	20	,	,	PUNCT
admet-2415	41	21	and	and	CCONJ
admet-2415	41	22	elimination	elimination	NOUN
admet-2415	41	23	kinetics	kinetic	NOUN
admet-2415	41	24	by	by	ADP
admet-2415	41	25	considering	consider	VERB
admet-2415	41	26	the	the	DET
admet-2415	41	27	kinetics	kinetic	NOUN
admet-2415	41	28	of	of	ADP
admet-2415	41	29	mass	mass	NOUN
admet-2415	41	30	balance	balance	NOUN
admet-2415	41	31	and	and	CCONJ
admet-2415	41	32	drug	drug	NOUN
admet-2415	41	33	transport	transport	NOUN
admet-2415	41	34	in	in	ADP
admet-2415	41	35	each	each	DET
admet-2415	41	36	organ	organ	NOUN
admet-2415	41	37	[	[	X
admet-2415	41	38	17,18	17,18	NUM
admet-2415	41	39	]	]	PUNCT
admet-2415	41	40	.	.	PUNCT
admet-2415	42	1	pd	pd	PROPN
admet-2415	42	2	modeling	model	VERB
admet-2415	42	3	quantifies	quantifie	NOUN
admet-2415	42	4	efficacy	efficacy	NOUN
admet-2415	42	5	kinetics	kinetic	NOUN
admet-2415	42	6	according	accord	VERB
admet-2415	42	7	to	to	ADP
admet-2415	42	8	the	the	DET
admet-2415	42	9	systemic	systemic	ADJ
admet-2415	42	10	and	and	CCONJ
admet-2415	42	11	local	local	ADJ
admet-2415	42	12	exposures	exposure	NOUN
admet-2415	42	13	of	of	ADP
admet-2415	42	14	drug	drug	NOUN
admet-2415	42	15	treatment	treatment	NOUN
admet-2415	42	16	.	.	PUNCT
admet-2415	43	1	a	a	DET
admet-2415	43	2	sensitivity	sensitivity	NOUN
admet-2415	43	3	analysis	analysis	NOUN
admet-2415	43	4	was	be	AUX
admet-2415	43	5	performed	perform	VERB
admet-2415	43	6	to	to	PART
admet-2415	43	7	evaluate	evaluate	VERB
admet-2415	43	8	the	the	DET
admet-2415	43	9	relationship	relationship	NOUN
admet-2415	43	10	among	among	ADP
admet-2415	43	11	various	various	ADJ
admet-2415	43	12	pbpk	pbpk	ADJ
admet-2415	43	13	parameters	parameter	NOUN
admet-2415	43	14	admet	admet	PROPN
admet-2415	43	15	&	&	CCONJ
admet-2415	43	16	dmpk	dmpk	PROPN
admet-2415	43	17	12(5	12(5	NUM
admet-2415	43	18	)	)	PUNCT
admet-2415	43	19	(	(	PUNCT
admet-2415	43	20	2024	2024	NUM
admet-2415	43	21	)	)	PUNCT
admet-2415	43	22	705	705	NUM
admet-2415	43	23	-	-	SYM
admet-2415	43	24	719	719	NUM
admet-2415	43	25	drug	drug	NOUN
admet-2415	43	26	delivery	delivery	NOUN
admet-2415	43	27	to	to	ADP
admet-2415	43	28	tumor	tumor	NOUN
admet-2415	43	29	by	by	ADP
admet-2415	43	30	nanoparticles	nanoparticle	NOUN
admet-2415	43	31	doi	doi	NOUN
admet-2415	43	32	:	:	PUNCT
admet-2415	43	33	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	43	34	707	707	NUM
admet-2415	43	35	and	and	CCONJ
admet-2415	43	36	identify	identify	VERB
admet-2415	43	37	significant	significant	ADJ
admet-2415	43	38	factors	factor	NOUN
admet-2415	43	39	.	.	PUNCT
admet-2415	44	1	additionally	additionally	ADV
admet-2415	44	2	,	,	PUNCT
admet-2415	44	3	the	the	DET
admet-2415	44	4	modeling	modeling	NOUN
admet-2415	44	5	and	and	CCONJ
admet-2415	44	6	simulation	simulation	NOUN
admet-2415	44	7	were	be	AUX
admet-2415	44	8	scaled	scale	VERB
admet-2415	44	9	to	to	ADP
admet-2415	44	10	human	human	ADJ
admet-2415	44	11	models	model	NOUN
admet-2415	44	12	to	to	PART
admet-2415	44	13	shed	shed	VERB
admet-2415	44	14	light	light	NOUN
admet-2415	44	15	on	on	ADP
admet-2415	44	16	the	the	DET
admet-2415	44	17	limitations	limitation	NOUN
admet-2415	44	18	of	of	ADP
admet-2415	44	19	using	use	VERB
admet-2415	44	20	animal	animal	NOUN
admet-2415	44	21	models	model	NOUN
admet-2415	44	22	for	for	ADP
admet-2415	44	23	testing	test	VERB
admet-2415	44	24	drug	drug	NOUN
admet-2415	44	25	delivery	delivery	NOUN
admet-2415	44	26	systems	system	NOUN
admet-2415	44	27	.	.	PUNCT
admet-2415	45	1	methodology	methodology	NOUN
admet-2415	45	2	pbpk	pbpk	NOUN
admet-2415	45	3	modeling	model	VERB
admet-2415	45	4	a	a	DET
admet-2415	45	5	whole	whole	ADJ
admet-2415	45	6	-	-	PUNCT
admet-2415	45	7	body	body	NOUN
admet-2415	45	8	physiologically	physiologically	ADV
admet-2415	45	9	based	base	VERB
admet-2415	45	10	pharmacokinetics	pharmacokinetic	NOUN
admet-2415	45	11	(	(	PUNCT
admet-2415	45	12	pbpk	pbpk	ADJ
admet-2415	45	13	)	)	PUNCT
admet-2415	45	14	model	model	NOUN
admet-2415	45	15	was	be	AUX
admet-2415	45	16	constructed	construct	VERB
admet-2415	45	17	(	(	PUNCT
admet-2415	45	18	figure	figure	NOUN
admet-2415	45	19	1	1	NUM
admet-2415	45	20	)	)	PUNCT
admet-2415	45	21	.	.	PUNCT
admet-2415	46	1	it	it	PRON
admet-2415	46	2	included	include	VERB
admet-2415	46	3	several	several	ADJ
admet-2415	46	4	major	major	ADJ
admet-2415	46	5	organ	organ	NOUN
admet-2415	46	6	compartments	compartment	NOUN
admet-2415	46	7	,	,	PUNCT
admet-2415	46	8	including	include	VERB
admet-2415	46	9	lungs	lung	NOUN
admet-2415	46	10	,	,	PUNCT
admet-2415	46	11	blood	blood	NOUN
admet-2415	46	12	,	,	PUNCT
admet-2415	46	13	heart	heart	NOUN
admet-2415	46	14	,	,	PUNCT
admet-2415	46	15	liver	liver	NOUN
admet-2415	46	16	,	,	PUNCT
admet-2415	46	17	spleen	spleen	NOUN
admet-2415	46	18	,	,	PUNCT
admet-2415	46	19	intestine	intestine	NOUN
admet-2415	46	20	,	,	PUNCT
admet-2415	46	21	kidney	kidney	NOUN
admet-2415	46	22	,	,	PUNCT
admet-2415	46	23	and	and	CCONJ
admet-2415	46	24	tumor	tumor	NOUN
admet-2415	46	25	.	.	PUNCT
admet-2415	47	1	all	all	DET
admet-2415	47	2	other	other	ADJ
admet-2415	47	3	tissues	tissue	NOUN
admet-2415	47	4	were	be	AUX
admet-2415	47	5	lumped	lump	VERB
admet-2415	47	6	into	into	ADP
admet-2415	47	7	the	the	DET
admet-2415	47	8	remainder	remainder	NOUN
admet-2415	47	9	compartment	compartment	NOUN
admet-2415	47	10	.	.	PUNCT
admet-2415	48	1	drug	drug	NOUN
admet-2415	48	2	transport	transport	NOUN
admet-2415	48	3	in	in	ADP
admet-2415	48	4	each	each	DET
admet-2415	48	5	compartment	compartment	NOUN
admet-2415	48	6	was	be	AUX
admet-2415	48	7	assumed	assume	VERB
admet-2415	48	8	to	to	PART
admet-2415	48	9	be	be	AUX
admet-2415	48	10	homogeneously	homogeneously	ADV
admet-2415	48	11	distributed	distribute	VERB
admet-2415	48	12	and	and	CCONJ
admet-2415	48	13	perfusion	perfusion	NOUN
admet-2415	48	14	-	-	PUNCT
admet-2415	48	15	limited	limit	VERB
admet-2415	48	16	modeling	modeling	NOUN
admet-2415	48	17	was	be	AUX
admet-2415	48	18	utilized	utilize	VERB
admet-2415	48	19	[	[	X
admet-2415	48	20	19,20	19,20	NOUN
admet-2415	48	21	]	]	PUNCT
admet-2415	48	22	.	.	PUNCT
admet-2415	49	1	figure	figure	NOUN
admet-2415	49	2	1	1	NUM
admet-2415	49	3	.	.	PUNCT
admet-2415	50	1	scheme	scheme	NOUN
admet-2415	50	2	of	of	ADP
admet-2415	50	3	whole	whole	ADJ
admet-2415	50	4	-	-	PUNCT
admet-2415	50	5	body	body	NOUN
admet-2415	50	6	pbpk	pbpk	ADJ
admet-2415	50	7	-	-	PROPN
admet-2415	50	8	pd	pd	ADJ
admet-2415	50	9	model	model	NOUN
admet-2415	50	10	.	.	PUNCT
admet-2415	51	1	following	follow	VERB
admet-2415	51	2	the	the	DET
admet-2415	51	3	mass	mass	NOUN
admet-2415	51	4	balance	balance	NOUN
admet-2415	51	5	through	through	ADP
admet-2415	51	6	all	all	DET
admet-2415	51	7	the	the	DET
admet-2415	51	8	compartments	compartment	NOUN
admet-2415	51	9	,	,	PUNCT
admet-2415	51	10	a	a	DET
admet-2415	51	11	general	general	ADJ
admet-2415	51	12	differential	differential	ADJ
admet-2415	51	13	equation	equation	NOUN
admet-2415	51	14	(	(	PUNCT
admet-2415	51	15	1	1	X
admet-2415	51	16	)	)	PUNCT
admet-2415	51	17	was	be	AUX
admet-2415	51	18	used	use	VERB
admet-2415	51	19	to	to	PART
admet-2415	51	20	quantify	quantify	VERB
admet-2415	51	21	drug	drug	NOUN
admet-2415	51	22	concentration	concentration	NOUN
admet-2415	51	23	in	in	ADP
admet-2415	51	24	a	a	DET
admet-2415	51	25	compartment	compartment	NOUN
admet-2415	51	26	:	:	PUNCT
admet-2415	51	27	(	(	PUNCT
admet-2415	51	28	)	)	PUNCT
admet-2415	51	29	compartment	compartment	NOUN
admet-2415	51	30	compartment	compartment	NOUN
admet-2415	51	31	compartment	compartment	NOUN
admet-2415	51	32	flow	flow	NOUN
admet-2415	51	33	-	-	PUNCT
admet-2415	51	34	in	in	ADP
admet-2415	51	35	flow	flow	NOUN
admet-2415	51	36	-	-	PUNCT
admet-2415	51	37	out	out	NOUN
admet-2415	51	38	d	d	PROPN
admet-2415	51	39	=	=	SYM
admet-2415	51	40	d	d	PROPN
admet-2415	51	41	c	c	NOUN
admet-2415	51	42	v	v	NOUN
admet-2415	51	43	q	q	X
admet-2415	51	44	c	c	NOUN
admet-2415	51	45	c	c	NOUN
admet-2415	51	46	t	t	NOUN
admet-2415	52	1	[	[	X
admet-2415	52	2	1	1	X
admet-2415	52	3	]	]	PUNCT
admet-2415	52	4	where	where	SCONJ
admet-2415	52	5	ccompartment	ccompartment	NOUN
admet-2415	52	6	/	/	PUNCT
admet-2415	52	7	m	m	VERB
admet-2415	52	8	is	be	AUX
admet-2415	52	9	drug	drug	NOUN
admet-2415	52	10	concentration	concentration	NOUN
admet-2415	52	11	,	,	PUNCT
admet-2415	53	1	vcompartment	vcompartment	NOUN
admet-2415	53	2	/	/	SYM
admet-2415	53	3	l	l	NOUN
admet-2415	53	4	is	be	AUX
admet-2415	53	5	volume	volume	NOUN
admet-2415	53	6	,	,	PUNCT
admet-2415	53	7	and	and	CCONJ
admet-2415	53	8	qcompartment	qcompartment	NOUN
admet-2415	53	9	/	/	SYM
admet-2415	53	10	l	l	NOUN
admet-2415	53	11	h-1is	h-1i	VERB
admet-2415	53	12	blood	blood	NOUN
admet-2415	53	13	flow	flow	NOUN
admet-2415	53	14	rate	rate	NOUN
admet-2415	53	15	in	in	ADP
admet-2415	53	16	the	the	DET
admet-2415	53	17	particular	particular	ADJ
admet-2415	53	18	organ	organ	NOUN
admet-2415	53	19	or	or	CCONJ
admet-2415	53	20	compartment	compartment	NOUN
admet-2415	53	21	.	.	PUNCT
admet-2415	54	1	cflow	cflow	NOUN
admet-2415	54	2	-	-	PUNCT
admet-2415	54	3	in	in	NOUN
admet-2415	54	4	represents	represent	VERB
admet-2415	54	5	the	the	DET
admet-2415	54	6	drug	drug	NOUN
admet-2415	54	7	concentration	concentration	NOUN
admet-2415	54	8	in	in	ADP
admet-2415	54	9	the	the	DET
admet-2415	54	10	blood	blood	NOUN
admet-2415	54	11	flowing	flow	VERB
admet-2415	54	12	into	into	ADP
admet-2415	54	13	the	the	DET
admet-2415	54	14	compartment	compartment	NOUN
admet-2415	54	15	and	and	CCONJ
admet-2415	54	16	cflow	cflow	NOUN
admet-2415	54	17	-	-	PUNCT
admet-2415	54	18	out	out	NOUN
admet-2415	54	19	represents	represent	VERB
admet-2415	54	20	that	that	SCONJ
admet-2415	54	21	flowing	flow	VERB
admet-2415	54	22	out	out	ADP
admet-2415	54	23	.	.	PUNCT
admet-2415	55	1	in	in	ADP
admet-2415	55	2	the	the	DET
admet-2415	55	3	following	follow	VERB
admet-2415	55	4	equations	equation	NOUN
admet-2415	55	5	,	,	PUNCT
admet-2415	55	6	subscripts	subscript	NOUN
admet-2415	55	7	are	be	AUX
admet-2415	55	8	used	use	VERB
admet-2415	55	9	to	to	PART
admet-2415	55	10	denote	denote	VERB
admet-2415	55	11	respective	respective	ADJ
admet-2415	55	12	organs	organ	NOUN
admet-2415	55	13	,	,	PUNCT
admet-2415	55	14	bl	bl	VERB
admet-2415	55	15	for	for	ADP
admet-2415	55	16	blood	blood	NOUN
admet-2415	55	17	,	,	PUNCT
admet-2415	55	18	lu	lu	NOUN
admet-2415	55	19	for	for	ADP
admet-2415	55	20	lung	lung	PROPN
admet-2415	55	21	,	,	PUNCT
admet-2415	55	22	li	li	PROPN
admet-2415	55	23	for	for	ADP
admet-2415	55	24	liver	liver	NOUN
admet-2415	55	25	(	(	PUNCT
admet-2415	55	26	in	in	ADP
admet-2415	55	27	particular	particular	ADJ
admet-2415	55	28	,	,	PUNCT
admet-2415	55	29	qli	qli	PROPN
admet-2415	55	30	denotes	denote	NOUN
admet-2415	55	31	hepatic	hepatic	ADJ
admet-2415	55	32	portal	portal	PROPN
admet-2415	55	33	vein	vein	VERB
admet-2415	55	34	flow	flow	NOUN
admet-2415	55	35	rate	rate	NOUN
admet-2415	55	36	and	and	CCONJ
admet-2415	55	37	heq	heq	VERB
admet-2415	55	38	qhe	qhe	PROPN
admet-2415	55	39	hepatic	hepatic	ADJ
admet-2415	55	40	artery	artery	NOUN
admet-2415	55	41	flow	flow	NOUN
admet-2415	55	42	rate	rate	NOUN
admet-2415	55	43	)	)	PUNCT
admet-2415	55	44	,	,	PUNCT
admet-2415	55	45	ht	ht	PROPN
admet-2415	55	46	for	for	ADP
admet-2415	55	47	heart	heart	NOUN
admet-2415	55	48	,	,	PUNCT
admet-2415	55	49	kd	kd	PROPN
admet-2415	55	50	for	for	ADP
admet-2415	55	51	kidney	kidney	PROPN
admet-2415	55	52	,	,	PUNCT
admet-2415	55	53	tu	tu	PROPN
admet-2415	55	54	for	for	ADP
admet-2415	55	55	tumor	tumor	NOUN
admet-2415	55	56	,	,	PUNCT
admet-2415	55	57	sp	sp	ADP
admet-2415	55	58	for	for	ADP
admet-2415	55	59	spleen	spleen	NOUN
admet-2415	55	60	,	,	PUNCT
admet-2415	55	61	and	and	CCONJ
admet-2415	55	62	rm	rm	NOUN
admet-2415	55	63	for	for	ADP
admet-2415	55	64	remainder	remainder	NOUN
admet-2415	55	65	.	.	PUNCT
admet-2415	56	1	assuming	assume	VERB
admet-2415	56	2	drug	drug	NOUN
admet-2415	56	3	diffusion	diffusion	NOUN
admet-2415	56	4	in	in	ADP
admet-2415	56	5	the	the	DET
admet-2415	56	6	tissue	tissue	NOUN
admet-2415	56	7	is	be	AUX
admet-2415	56	8	not	not	PART
admet-2415	56	9	the	the	DET
admet-2415	56	10	rate	rate	NOUN
admet-2415	56	11	-	-	PUNCT
admet-2415	56	12	limiting	limit	VERB
admet-2415	56	13	step	step	NOUN
admet-2415	56	14	,	,	PUNCT
admet-2415	56	15	the	the	DET
admet-2415	56	16	drug	drug	NOUN
admet-2415	56	17	concentration	concentration	NOUN
admet-2415	56	18	in	in	ADP
admet-2415	56	19	each	each	DET
admet-2415	56	20	organ	organ	NOUN
admet-2415	56	21	can	can	AUX
admet-2415	56	22	be	be	AUX
admet-2415	56	23	described	describe	VERB
admet-2415	56	24	by	by	ADP
admet-2415	56	25	drug	drug	NOUN
admet-2415	56	26	partitioning	partitioning	NOUN
admet-2415	56	27	between	between	ADP
admet-2415	56	28	the	the	DET
admet-2415	56	29	blood	blood	NOUN
admet-2415	56	30	and	and	CCONJ
admet-2415	56	31	organ	organ	NOUN
admet-2415	56	32	as	as	SCONJ
admet-2415	56	33	quantified	quantify	VERB
admet-2415	56	34	by	by	ADP
admet-2415	56	35	the	the	DET
admet-2415	56	36	partition	partition	NOUN
admet-2415	56	37	coefficient	coefficient	NOUN
admet-2415	56	38	,	,	PUNCT
admet-2415	56	39	kcompartment	kcompartment	PROPN
admet-2415	56	40	,	,	PUNCT
admet-2415	56	41	which	which	PRON
admet-2415	56	42	is	be	AUX
admet-2415	56	43	unitless	unitless	NOUN
admet-2415	56	44	.	.	PUNCT
admet-2415	57	1	ptx	ptx	NOUN
admet-2415	57	2	elimination	elimination	NOUN
admet-2415	57	3	mainly	mainly	ADV
admet-2415	57	4	occurs	occur	VERB
admet-2415	57	5	in	in	ADP
admet-2415	57	6	liver	liver	NOUN
admet-2415	57	7	[	[	X
admet-2415	57	8	21	21	NUM
admet-2415	57	9	]	]	X
admet-2415	57	10	,	,	PUNCT
admet-2415	57	11	which	which	PRON
admet-2415	57	12	is	be	AUX
admet-2415	57	13	assumed	assume	VERB
admet-2415	57	14	to	to	PART
admet-2415	57	15	be	be	AUX
admet-2415	57	16	a	a	DET
admet-2415	57	17	linear	linear	ADJ
admet-2415	57	18	process	process	NOUN
admet-2415	57	19	described	describe	VERB
admet-2415	57	20	by	by	ADP
admet-2415	57	21	clliv	clliv	PROPN
admet-2415	57	22	.	.	PUNCT
admet-2415	58	1	each	each	DET
admet-2415	58	2	compartment	compartment	NOUN
admet-2415	58	3	is	be	AUX
admet-2415	58	4	then	then	ADV
admet-2415	58	5	described	describe	VERB
admet-2415	58	6	as	as	ADP
admet-2415	58	7	by	by	ADP
admet-2415	58	8	the	the	DET
admet-2415	58	9	following	follow	VERB
admet-2415	58	10	equations	equation	NOUN
admet-2415	58	11	(	(	PUNCT
admet-2415	58	12	2	2	NUM
admet-2415	58	13	)	)	PUNCT
admet-2415	58	14	to	to	ADP
admet-2415	58	15	(	(	PUNCT
admet-2415	58	16	9	9	NUM
admet-2415	58	17	)	)	PUNCT
admet-2415	58	18	.	.	PUNCT
admet-2415	59	1	blood	blood	NOUN
admet-2415	59	2	:	:	PUNCT
admet-2415	59	3	bl	bl	PROPN
admet-2415	60	1	lu	lu	INTJ
admet-2415	60	2	bl	bl	INTJ
admet-2415	60	3	lu	lu	INTJ
admet-2415	60	4	bl	bl	INTJ
admet-2415	60	5	lu	lu	PROPN
admet-2415	61	1	d	d	NOUN
admet-2415	61	2	=	=	PUNCT
admet-2415	62	1	d	d	X
admet-2415	62	2	c	c	NOUN
admet-2415	62	3	c	c	NOUN
admet-2415	62	4	v	v	NOUN
admet-2415	62	5	q	q	PROPN
admet-2415	63	1	c	c	NOUN
admet-2415	63	2	t	t	PROPN
admet-2415	63	3	k	k	PROPN
admet-2415	63	4			PROPN
admet-2415	63	5			PROPN
admet-2415	63	6			PROPN
admet-2415	63	7			PROPN
admet-2415	64	1			PROPN
admet-2415	64	2			NOUN
admet-2415	64	3	[	[	X
admet-2415	64	4	2	2	NUM
admet-2415	64	5	]	]	PUNCT
admet-2415	64	6	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	64	7	s.	s.	PROPN
admet-2415	64	8	lu	lu	PROPN
admet-2415	64	9	et	et	PROPN
admet-2415	64	10	al	al	PROPN
admet-2415	64	11	.	.	PROPN
admet-2415	64	12	admet	admet	PROPN
admet-2415	64	13	&	&	CCONJ
admet-2415	64	14	dmpk	dmpk	PROPN
admet-2415	64	15	12(5	12(5	NUM
admet-2415	64	16	)	)	PUNCT
admet-2415	64	17	(	(	PUNCT
admet-2415	64	18	2024	2024	NUM
admet-2415	64	19	)	)	PUNCT
admet-2415	64	20	705	705	NUM
admet-2415	64	21	-	-	SYM
admet-2415	64	22	719	719	NUM
admet-2415	64	23	708	708	NUM
admet-2415	64	24	lung	lung	NOUN
admet-2415	64	25	:	:	PUNCT
admet-2415	65	1	lu	lu	PROPN
admet-2415	65	2	ht	ht	INTJ
admet-2415	66	1	kd	kd	PROPN
admet-2415	66	2	tu	tu	PROPN
admet-2415	66	3	luli	luli	PROPN
admet-2415	66	4	rm	rm	PROPN
admet-2415	67	1	lu	lu	PROPN
admet-2415	67	2	li	li	PROPN
admet-2415	68	1	ht	ht	PROPN
admet-2415	68	2	kd	kd	PROPN
admet-2415	68	3	tu	tu	PROPN
admet-2415	68	4	rm	rm	PROPN
admet-2415	68	5	lu	lu	PROPN
admet-2415	68	6	li	li	PROPN
admet-2415	69	1	ht	ht	PROPN
admet-2415	69	2	tu	tu	PROPN
admet-2415	69	3	rm	rm	PROPN
admet-2415	69	4	lu	lu	PROPN
admet-2415	70	1	d	d	PROPN
admet-2415	70	2	=	=	PUNCT
admet-2415	71	1	+	+	PUNCT
admet-2415	71	2	+	+	PUNCT
admet-2415	72	1	+	+	PUNCT
admet-2415	72	2	+	+	NOUN
admet-2415	72	3	d	d	X
admet-2415	72	4	c	c	NOUN
admet-2415	72	5	c	c	NOUN
admet-2415	72	6	c	c	NOUN
admet-2415	72	7	c	c	NOUN
admet-2415	72	8	cc	cc	PROPN
admet-2415	72	9	c	c	PROPN
admet-2415	72	10	v	v	NOUN
admet-2415	72	11	q	q	NOUN
admet-2415	72	12	q	q	X
admet-2415	72	13	q	q	X
admet-2415	72	14	q	q	X
admet-2415	72	15	q	q	X
admet-2415	72	16	q	q	X
admet-2415	72	17	t	t	PROPN
admet-2415	72	18	k	k	PROPN
admet-2415	73	1	k	k	PROPN
admet-2415	73	2	kd	kd	PROPN
admet-2415	74	1	k	k	PROPN
admet-2415	74	2	k	k	PROPN
admet-2415	74	3	k	k	PROPN
admet-2415	75	1	+	+	PUNCT
admet-2415	75	2	[	[	X
admet-2415	75	3	3	3	NUM
admet-2415	75	4	]	]	PUNCT
admet-2415	75	5	spleen	spleen	NOUN
admet-2415	75	6	:	:	PUNCT
admet-2415	75	7	sp	sp	ADP
admet-2415	75	8	sp	sp	ADP
admet-2415	75	9	sp	sp	ADP
admet-2415	75	10	sp	sp	ADP
admet-2415	75	11	bl	bl	INTJ
admet-2415	75	12	sp	sp	NOUN
admet-2415	75	13	d	d	PROPN
admet-2415	75	14	=	=	PUNCT
admet-2415	76	1	d	d	X
admet-2415	76	2	c	c	NOUN
admet-2415	76	3	c	c	NOUN
admet-2415	76	4	v	v	NOUN
admet-2415	76	5	q	q	PROPN
admet-2415	77	1	c	c	NOUN
admet-2415	77	2	t	t	PROPN
admet-2415	77	3	k	k	PROPN
admet-2415	77	4			PROPN
admet-2415	77	5			PROPN
admet-2415	77	6			PROPN
admet-2415	77	7			NOUN
admet-2415	78	1			PROPN
admet-2415	78	2			ADJ
admet-2415	78	3			NOUN
admet-2415	78	4	[	[	X
admet-2415	78	5	4	4	NUM
admet-2415	78	6	]	]	PUNCT
admet-2415	78	7	liver	liver	NOUN
admet-2415	78	8	:	:	PUNCT
admet-2415	78	9	spli	spli	PROPN
admet-2415	78	10	li	li	PROPN
admet-2415	78	11	li	li	PROPN
admet-2415	79	1	he	he	PRON
admet-2415	79	2	bl	bl	PROPN
admet-2415	79	3	sp	sp	ADP
admet-2415	79	4	li	li	PROPN
admet-2415	79	5	li	li	PROPN
admet-2415	79	6	liv	liv	PROPN
admet-2415	79	7	sp	sp	ADP
admet-2415	79	8	li	li	PROPN
admet-2415	79	9	d	d	PROPN
admet-2415	79	10	=	=	PROPN
admet-2415	80	1	+	+	NUM
admet-2415	80	2	d	d	NOUN
admet-2415	80	3	cc	cc	ADP
admet-2415	80	4	c	c	NOUN
admet-2415	80	5	v	v	NOUN
admet-2415	80	6	q	q	PROPN
admet-2415	80	7	c	c	NOUN
admet-2415	80	8	q	q	NOUN
admet-2415	80	9	q	q	X
admet-2415	80	10	c	c	NOUN
admet-2415	80	11	cl	cl	NOUN
admet-2415	80	12	t	t	NOUN
admet-2415	81	1	k	k	PROPN
admet-2415	81	2	k	k	PROPN
admet-2415	82	1	[	[	X
admet-2415	82	2	5	5	NUM
admet-2415	82	3	]	]	PUNCT
admet-2415	82	4	heart	heart	NOUN
admet-2415	82	5	:	:	PUNCT
admet-2415	83	1	ht	ht	INTJ
admet-2415	83	2	ht	ht	INTJ
admet-2415	84	1	ht	ht	INTJ
admet-2415	84	2	ht	ht	INTJ
admet-2415	84	3	bl	bl	INTJ
admet-2415	84	4	ht	ht	PROPN
admet-2415	85	1	d	d	PROPN
admet-2415	85	2	=	=	PUNCT
admet-2415	85	3	d	d	X
admet-2415	85	4	c	c	NOUN
admet-2415	85	5	c	c	NOUN
admet-2415	85	6	v	v	NOUN
admet-2415	85	7	q	q	PROPN
admet-2415	85	8	c	c	NOUN
admet-2415	85	9	t	t	PROPN
admet-2415	85	10	k	k	PROPN
admet-2415	85	11			PROPN
admet-2415	85	12			PROPN
admet-2415	85	13	−	−	PROPN
admet-2415	85	14			PROPN
admet-2415	86	1			PROPN
admet-2415	86	2			NOUN
admet-2415	86	3	[	[	X
admet-2415	86	4	6	6	NUM
admet-2415	86	5	]	]	X
admet-2415	86	6	kidney	kidney	NOUN
admet-2415	86	7	:	:	PUNCT
admet-2415	86	8	kd	kd	PROPN
admet-2415	86	9	kd	kd	PROPN
admet-2415	86	10	kd	kd	PROPN
admet-2415	86	11	kd	kd	PROPN
admet-2415	86	12	bl	bl	PROPN
admet-2415	86	13	kd	kd	PROPN
admet-2415	87	1	d	d	PROPN
admet-2415	87	2	=	=	PROPN
admet-2415	87	3	d	d	X
admet-2415	87	4	c	c	NOUN
admet-2415	87	5	c	c	NOUN
admet-2415	87	6	v	v	NOUN
admet-2415	87	7	q	q	PROPN
admet-2415	87	8	c	c	NOUN
admet-2415	87	9	t	t	PROPN
admet-2415	87	10	k	k	PROPN
admet-2415	87	11			PROPN
admet-2415	87	12			PROPN
admet-2415	87	13			PROPN
admet-2415	87	14			PROPN
admet-2415	88	1			ADJ
admet-2415	88	2			NOUN
admet-2415	88	3	[	[	X
admet-2415	88	4	7	7	NUM
admet-2415	88	5	]	]	PUNCT
admet-2415	88	6	tumor	tumor	NOUN
admet-2415	88	7	:	:	PUNCT
admet-2415	89	1	tu	tu	PROPN
admet-2415	89	2	tu	tu	PROPN
admet-2415	89	3	tu	tu	PROPN
admet-2415	89	4	tu	tu	PROPN
admet-2415	89	5	tu	tu	PROPN
admet-2415	89	6	tu	tu	PROPN
admet-2415	89	7	d	d	PROPN
admet-2415	89	8	=	=	PUNCT
admet-2415	89	9	d	d	X
admet-2415	89	10	c	c	NOUN
admet-2415	89	11	c	c	NOUN
admet-2415	89	12	v	v	NOUN
admet-2415	89	13	q	q	PROPN
admet-2415	89	14	c	c	NOUN
admet-2415	89	15	t	t	PROPN
admet-2415	89	16	k	k	PROPN
admet-2415	89	17			PROPN
admet-2415	89	18			PROPN
admet-2415	89	19			PROPN
admet-2415	89	20			PROPN
admet-2415	89	21			PROPN
admet-2415	89	22			NOUN
admet-2415	89	23	[	[	X
admet-2415	89	24	8	8	NUM
admet-2415	89	25	]	]	PUNCT
admet-2415	89	26	reminder	reminder	NOUN
admet-2415	89	27	:	:	PUNCT
admet-2415	89	28	rm	rm	PROPN
admet-2415	89	29	rm	rm	PROPN
admet-2415	89	30	rm	rm	PROPN
admet-2415	89	31	rm	rm	PROPN
admet-2415	89	32	bl	bl	PROPN
admet-2415	89	33	rm	rm	PROPN
admet-2415	90	1	d	d	PROPN
admet-2415	90	2	=	=	PROPN
admet-2415	91	1	d	d	X
admet-2415	91	2	c	c	NOUN
admet-2415	91	3	c	c	NOUN
admet-2415	91	4	v	v	NOUN
admet-2415	91	5	q	q	PROPN
admet-2415	92	1	c	c	NOUN
admet-2415	92	2	t	t	PROPN
admet-2415	92	3	k	k	PROPN
admet-2415	92	4			PROPN
admet-2415	92	5			PROPN
admet-2415	92	6			PROPN
admet-2415	92	7			PROPN
admet-2415	93	1			ADJ
admet-2415	93	2			NOUN
admet-2415	94	1	[	[	X
admet-2415	94	2	9	9	NUM
admet-2415	94	3	]	]	X
admet-2415	94	4	the	the	DET
admet-2415	94	5	multiple	multiple	ADJ
admet-2415	94	6	terms	term	NOUN
admet-2415	94	7	in	in	ADP
admet-2415	94	8	the	the	DET
admet-2415	94	9	lung	lung	NOUN
admet-2415	94	10	equation	equation	NOUN
admet-2415	94	11	account	account	VERB
admet-2415	94	12	for	for	ADP
admet-2415	94	13	the	the	DET
admet-2415	94	14	venous	venous	ADJ
admet-2415	94	15	flow	flow	NOUN
admet-2415	94	16	-	-	PUNCT
admet-2415	94	17	in	in	ADV
admet-2415	94	18	from	from	ADP
admet-2415	94	19	major	major	ADJ
admet-2415	94	20	organs	organ	NOUN
admet-2415	94	21	and	and	CCONJ
admet-2415	94	22	the	the	DET
admet-2415	94	23	arterial	arterial	ADJ
admet-2415	94	24	flow	flow	NOUN
admet-2415	94	25	-	-	PUNCT
admet-2415	94	26	out	out	ADP
admet-2415	94	27	(	(	PUNCT
admet-2415	94	28	figure	figure	NOUN
admet-2415	94	29	1	1	NUM
admet-2415	94	30	)	)	PUNCT
admet-2415	94	31	.	.	PUNCT
admet-2415	95	1	the	the	DET
admet-2415	95	2	liver	liver	NOUN
admet-2415	95	3	equation	equation	NOUN
admet-2415	95	4	considers	consider	VERB
admet-2415	95	5	the	the	DET
admet-2415	95	6	flow	flow	NOUN
admet-2415	95	7	-	-	PUNCT
admet-2415	95	8	in	in	ADP
admet-2415	95	9	from	from	ADP
admet-2415	95	10	the	the	DET
admet-2415	95	11	spleen	spleen	NOUN
admet-2415	95	12	and	and	CCONJ
admet-2415	95	13	hepatic	hepatic	ADJ
admet-2415	95	14	clearance	clearance	NOUN
admet-2415	95	15	of	of	ADP
admet-2415	95	16	the	the	DET
admet-2415	95	17	drug	drug	NOUN
admet-2415	95	18	.	.	PUNCT
admet-2415	96	1	table	table	NOUN
admet-2415	96	2	1	1	NUM
admet-2415	96	3	lists	list	VERB
admet-2415	96	4	the	the	DET
admet-2415	96	5	physiological	physiological	ADJ
admet-2415	96	6	parameters	parameter	NOUN
admet-2415	96	7	used	use	VERB
admet-2415	96	8	in	in	ADP
admet-2415	96	9	the	the	DET
admet-2415	96	10	equations	equation	NOUN
admet-2415	96	11	;	;	PUNCT
admet-2415	96	12	the	the	DET
admet-2415	96	13	blood	blood	NOUN
admet-2415	96	14	flow	flow	NOUN
admet-2415	96	15	rates	rate	NOUN
admet-2415	96	16	were	be	AUX
admet-2415	96	17	obtained	obtain	VERB
admet-2415	96	18	from	from	ADP
admet-2415	96	19	the	the	DET
admet-2415	96	20	literature	literature	NOUN
admet-2415	96	21	[	[	X
admet-2415	96	22	22,23	22,23	NOUN
admet-2415	96	23	]	]	PUNCT
admet-2415	96	24	and	and	CCONJ
admet-2415	96	25	the	the	DET
admet-2415	96	26	organ	organ	NOUN
admet-2415	96	27	volume	volume	NOUN
admet-2415	96	28	were	be	AUX
admet-2415	96	29	measured	measure	VERB
admet-2415	96	30	in	in	ADP
admet-2415	96	31	our	our	PRON
admet-2415	96	32	animal	animal	NOUN
admet-2415	96	33	studies	study	NOUN
admet-2415	96	34	used	use	VERB
admet-2415	96	35	to	to	PART
admet-2415	96	36	evaluate	evaluate	VERB
admet-2415	96	37	ptx	ptx	NOUN
admet-2415	96	38	ncs	nc	NOUN
admet-2415	96	39	.	.	PUNCT
admet-2415	97	1	organ	organ	NOUN
admet-2415	97	2	volumes	volume	NOUN
admet-2415	97	3	were	be	AUX
admet-2415	97	4	determined	determine	VERB
admet-2415	97	5	by	by	ADP
admet-2415	97	6	organ	organ	NOUN
admet-2415	97	7	weights	weight	NOUN
admet-2415	97	8	with	with	ADP
admet-2415	97	9	the	the	DET
admet-2415	97	10	tissue	tissue	NOUN
admet-2415	97	11	density	density	NOUN
admet-2415	97	12	of	of	ADP
admet-2415	97	13	1.18	1.18	NUM
admet-2415	97	14	g	g	NOUN
admet-2415	97	15	/	/	SYM
admet-2415	97	16	ml	ml	PROPN
admet-2415	98	1	[	[	X
admet-2415	98	2	24	24	NUM
admet-2415	98	3	]	]	PUNCT
admet-2415	98	4	.	.	PUNCT
admet-2415	99	1	partition	partition	NOUN
admet-2415	99	2	coefficients	coefficient	NOUN
admet-2415	99	3	and	and	CCONJ
admet-2415	99	4	the	the	DET
admet-2415	99	5	liver	liver	NOUN
admet-2415	99	6	clearance	clearance	NOUN
admet-2415	99	7	rate	rate	NOUN
admet-2415	99	8	were	be	AUX
admet-2415	99	9	determined	determine	VERB
admet-2415	99	10	by	by	ADP
admet-2415	99	11	data	datum	NOUN
admet-2415	99	12	fitting	fitting	ADJ
admet-2415	99	13	of	of	ADP
admet-2415	99	14	the	the	DET
admet-2415	99	15	pbpk	pbpk	ADJ
admet-2415	99	16	model	model	NOUN
admet-2415	99	17	against	against	ADP
admet-2415	99	18	our	our	PRON
admet-2415	99	19	experimental	experimental	ADJ
admet-2415	99	20	values	value	NOUN
admet-2415	99	21	using	use	VERB
admet-2415	99	22	nonlinear	nonlinear	ADJ
admet-2415	99	23	least	least	ADJ
admet-2415	99	24	squares	square	NOUN
admet-2415	99	25	(	(	PUNCT
admet-2415	99	26	nls)[25	nls)[25	NOUN
admet-2415	99	27	]	]	X
admet-2415	99	28	.	.	PUNCT
admet-2415	100	1	the	the	DET
admet-2415	100	2	pk	pk	PROPN
admet-2415	100	3	parameters	parameter	NOUN
admet-2415	100	4	in	in	ADP
admet-2415	100	5	the	the	DET
admet-2415	100	6	above	above	ADJ
admet-2415	100	7	questions	question	NOUN
admet-2415	100	8	,	,	PUNCT
admet-2415	100	9	including	include	VERB
admet-2415	100	10	partition	partition	NOUN
admet-2415	100	11	coefficients	coefficient	NOUN
admet-2415	100	12	,	,	PUNCT
admet-2415	100	13	are	be	AUX
admet-2415	100	14	adjusted	adjust	VERB
admet-2415	100	15	and	and	CCONJ
admet-2415	100	16	optimized	optimize	VERB
admet-2415	100	17	during	during	ADP
admet-2415	100	18	the	the	DET
admet-2415	100	19	nls	nls	NOUN
admet-2415	100	20	process	process	NOUN
admet-2415	100	21	to	to	PART
admet-2415	100	22	minimize	minimize	VERB
admet-2415	100	23	the	the	DET
admet-2415	100	24	resident	resident	ADJ
admet-2415	100	25	errors	error	NOUN
admet-2415	100	26	between	between	ADP
admet-2415	100	27	the	the	DET
admet-2415	100	28	experimental	experimental	ADJ
admet-2415	100	29	data	datum	NOUN
admet-2415	100	30	and	and	CCONJ
admet-2415	100	31	model	model	NOUN
admet-2415	100	32	-	-	PUNCT
admet-2415	100	33	predicted	predict	VERB
admet-2415	100	34	values	value	NOUN
admet-2415	100	35	of	of	ADP
admet-2415	100	36	drug	drug	NOUN
admet-2415	100	37	concentrations	concentration	NOUN
admet-2415	100	38	.	.	PUNCT
admet-2415	101	1	the	the	DET
admet-2415	101	2	model	model	NOUN
admet-2415	101	3	was	be	AUX
admet-2415	101	4	fitted	fit	VERB
admet-2415	101	5	with	with	ADP
admet-2415	101	6	a	a	DET
admet-2415	101	7	tolerance	tolerance	NOUN
admet-2415	101	8	of	of	ADP
admet-2415	101	9	10	10	NUM
admet-2415	101	10	-	-	SYM
admet-2415	101	11	8	8	NUM
admet-2415	101	12	.	.	PUNCT
admet-2415	102	1	all	all	DET
admet-2415	102	2	calculations	calculation	NOUN
admet-2415	102	3	were	be	AUX
admet-2415	102	4	done	do	VERB
admet-2415	102	5	by	by	ADP
admet-2415	102	6	matlab	matlab	PROPN
admet-2415	102	7	(	(	PUNCT
admet-2415	102	8	version	version	NOUN
admet-2415	102	9	r2018a	r2018a	PROPN
admet-2415	103	1	[	[	X
admet-2415	103	2	26	26	NUM
admet-2415	103	3	]	]	NUM
admet-2415	103	4	)	)	PUNCT
admet-2415	103	5	.	.	PUNCT
admet-2415	104	1	table	table	NOUN
admet-2415	104	2	1	1	NUM
admet-2415	104	3	.	.	PUNCT
admet-2415	105	1	physiological	physiological	ADJ
admet-2415	105	2	parameters	parameter	NOUN
admet-2415	105	3	used	use	VERB
admet-2415	105	4	for	for	ADP
admet-2415	105	5	mice	mouse	NOUN
admet-2415	105	6	.	.	PUNCT
admet-2415	106	1	tissue	tissue	NOUN
admet-2415	106	2	plasma	plasma	NOUN
admet-2415	106	3	flow	flow	NOUN
admet-2415	106	4	,	,	PUNCT
admet-2415	106	5	l	l	NOUN
admet-2415	106	6	/	/	SYM
admet-2415	106	7	h	h	NOUN
admet-2415	106	8	organ	organ	NOUN
admet-2415	106	9	volume	volume	NOUN
admet-2415	106	10	,	,	PUNCT
admet-2415	106	11	l	l	NOUN
admet-2415	106	12	blood	blood	NOUN
admet-2415	106	13	0.48ǂ	0.48ǂ	VERB
admet-2415	107	1	0.0017ǂ	0.0017ǂ	ADJ
admet-2415	107	2	liver	liver	NOUN
admet-2415	107	3	0.108ǂ	0.108ǂ	NOUN
admet-2415	107	4	0.0015	0.0015	NUM
admet-2415	107	5	*	*	NOUN
admet-2415	107	6	spleen	spleen	NOUN
admet-2415	107	7	0.0054ǂ	0.0054ǂ	NOUN
admet-2415	107	8	0.0000847	0.0000847	NUM
admet-2415	107	9	*	*	PUNCT
admet-2415	107	10	heart	heart	NOUN
admet-2415	107	11	0.0168ǂ	0.0168ǂ	NOUN
admet-2415	107	12	0.0000678	0.0000678	NUM
admet-2415	107	13	*	*	PUNCT
admet-2415	107	14	lung	lung	NOUN
admet-2415	107	15	0.48ǂ	0.48ǂ	NUM
admet-2415	107	16	0.00010	0.00010	NUM
admet-2415	107	17	*	*	PUNCT
admet-2415	107	18	kidney	kidney	NOUN
admet-2415	107	19	0.078ǂ	0.078ǂ	NOUN
admet-2415	107	20	0.00027	0.00027	NUM
admet-2415	107	21	*	*	PUNCT
admet-2415	107	22	tumor	tumor	NOUN
admet-2415	107	23	0.00102ǂ	0.00102ǂ	PROPN
admet-2415	107	24	0.0016	0.0016	NUM
admet-2415	107	25	*	*	PUNCT
admet-2415	107	26	remainder	remainder	VERB
admet-2415	107	27	0.27618	0.27618	NUM
admet-2415	107	28	0.013	0.013	NUM
admet-2415	107	29	*	*	PUNCT
admet-2415	107	30	hepatic	hepatic	ADJ
admet-2415	107	31	flow	flow	NOUN
admet-2415	107	32	rate	rate	NOUN
admet-2415	107	33	0.021ǂ	0.021ǂ	NUM
admet-2415	107	34	ǂplasma	ǂplasma	NOUN
admet-2415	107	35	flow	flow	NOUN
admet-2415	107	36	and	and	CCONJ
admet-2415	107	37	blood	blood	NOUN
admet-2415	107	38	volume	volume	NOUN
admet-2415	107	39	were	be	AUX
admet-2415	107	40	obtained	obtain	VERB
admet-2415	107	41	from	from	ADP
admet-2415	107	42	the	the	DET
admet-2415	107	43	literature	literature	NOUN
admet-2415	108	1	[	[	X
admet-2415	108	2	22,23	22,23	NOUN
admet-2415	108	3	]	]	PUNCT
admet-2415	108	4	.	.	PUNCT
admet-2415	109	1	*	*	PUNCT
admet-2415	109	2	organ	organ	NOUN
admet-2415	109	3	volume	volume	NOUN
admet-2415	109	4	was	be	AUX
admet-2415	109	5	calculated	calculate	VERB
admet-2415	109	6	with	with	ADP
admet-2415	109	7	average	average	ADJ
admet-2415	109	8	measurement	measurement	NOUN
admet-2415	109	9	reported	report	VERB
admet-2415	109	10	in	in	ADP
admet-2415	109	11	our	our	PRON
admet-2415	109	12	previous	previous	ADJ
admet-2415	109	13	study	study	NOUN
admet-2415	109	14	[	[	X
admet-2415	109	15	11	11	NUM
admet-2415	109	16	]	]	PUNCT
admet-2415	109	17	.	.	PUNCT
admet-2415	110	1	pd	pd	PROPN
admet-2415	110	2	modeling	model	VERB
admet-2415	110	3	a	a	DET
admet-2415	110	4	transit	transit	NOUN
admet-2415	110	5	compartmental	compartmental	PROPN
admet-2415	110	6	pd	pd	PROPN
admet-2415	110	7	model	model	NOUN
admet-2415	110	8	was	be	AUX
admet-2415	110	9	coupled	couple	VERB
admet-2415	110	10	with	with	ADP
admet-2415	110	11	the	the	DET
admet-2415	110	12	drug	drug	NOUN
admet-2415	110	13	exposure	exposure	NOUN
admet-2415	110	14	kinetics	kinetic	NOUN
admet-2415	110	15	in	in	ADP
admet-2415	110	16	the	the	DET
admet-2415	110	17	tumor	tumor	NOUN
admet-2415	110	18	that	that	PRON
admet-2415	110	19	is	be	AUX
admet-2415	110	20	calculated	calculate	VERB
admet-2415	110	21	by	by	ADP
admet-2415	110	22	pbpk	pbpk	NOUN
admet-2415	110	23	(	(	PUNCT
admet-2415	110	24	figure	figure	NOUN
admet-2415	110	25	1	1	NUM
admet-2415	110	26	)	)	PUNCT
admet-2415	111	1	[	[	X
admet-2415	111	2	27	27	NUM
admet-2415	111	3	-	-	SYM
admet-2415	111	4	29	29	NUM
admet-2415	111	5	]	]	PUNCT
admet-2415	111	6	.	.	PUNCT
admet-2415	112	1	in	in	ADP
admet-2415	112	2	the	the	DET
admet-2415	112	3	early	early	ADJ
admet-2415	112	4	stage	stage	NOUN
admet-2415	112	5	of	of	ADP
admet-2415	112	6	cell	cell	NOUN
admet-2415	112	7	proliferation	proliferation	NOUN
admet-2415	112	8	,	,	PUNCT
admet-2415	112	9	tumor	tumor	NOUN
admet-2415	112	10	growth	growth	NOUN
admet-2415	112	11	is	be	AUX
admet-2415	112	12	treated	treat	VERB
admet-2415	112	13	exponentially	exponentially	ADV
admet-2415	112	14	.	.	PUNCT
admet-2415	113	1	angiogenesis	angiogenesis	NOUN
admet-2415	113	2	and	and	CCONJ
admet-2415	113	3	nutrient	nutrient	NOUN
admet-2415	113	4	depletion	depletion	NOUN
admet-2415	113	5	will	will	AUX
admet-2415	113	6	impede	impede	VERB
admet-2415	113	7	the	the	DET
admet-2415	113	8	process	process	NOUN
admet-2415	113	9	at	at	ADP
admet-2415	113	10	the	the	DET
admet-2415	113	11	later	later	ADJ
admet-2415	113	12	stage	stage	NOUN
admet-2415	113	13	,	,	PUNCT
admet-2415	113	14	resulting	result	VERB
admet-2415	113	15	in	in	ADP
admet-2415	113	16	the	the	DET
admet-2415	113	17	linear	linear	ADJ
admet-2415	113	18	growth	growth	NOUN
admet-2415	113	19	of	of	ADP
admet-2415	113	20	tumor	tumor	NOUN
admet-2415	113	21	[	[	X
admet-2415	113	22	30	30	NUM
admet-2415	113	23	]	]	PUNCT
admet-2415	113	24	.	.	PUNCT
admet-2415	114	1	to	to	PART
admet-2415	114	2	account	account	VERB
admet-2415	114	3	for	for	ADP
admet-2415	114	4	the	the	DET
admet-2415	114	5	lapse	lapse	NOUN
admet-2415	114	6	between	between	ADP
admet-2415	114	7	drug	drug	NOUN
admet-2415	114	8	exposure	exposure	NOUN
admet-2415	114	9	and	and	CCONJ
admet-2415	114	10	cell	cell	NOUN
admet-2415	114	11	apoptosis	apoptosis	NOUN
admet-2415	114	12	,	,	PUNCT
admet-2415	114	13	three	three	NUM
admet-2415	114	14	transit	transit	NOUN
admet-2415	114	15	compartments	compartment	NOUN
admet-2415	114	16	are	be	AUX
admet-2415	114	17	utilized	utilize	VERB
admet-2415	114	18	in	in	ADP
admet-2415	114	19	the	the	DET
admet-2415	114	20	pd	pd	PROPN
admet-2415	114	21	model	model	NOUN
admet-2415	114	22	(	(	PUNCT
admet-2415	114	23	equation	equation	NOUN
admet-2415	114	24	(	(	PUNCT
admet-2415	114	25	10	10	NUM
admet-2415	114	26	)	)	PUNCT
admet-2415	114	27	)	)	PUNCT
admet-2415	114	28	:	:	PUNCT
admet-2415	115	1	(	(	PUNCT
admet-2415	115	2	)	)	PUNCT
admet-2415	115	3	(	(	PUNCT
admet-2415	115	4	)	)	PUNCT
admet-2415	115	5	(	(	PUNCT
admet-2415	115	6	)	)	PUNCT
admet-2415	115	7	(	(	PUNCT
admet-2415	115	8	)	)	SYM
admet-2415	115	9	1	1	NUM
admet-2415	115	10	d	d	SYM
admet-2415	115	11	1	1	NUM
admet-2415	115	12	d	d	NOUN
admet-2415	115	13	  	  	SPACE
admet-2415	115	14	1	1	NUM
admet-2415	115	15	d	d	PROPN
admet-2415	115	16	w	w	PROPN
admet-2415	115	17	t	t	PROPN
admet-2415	115	18	k	k	PROPN
admet-2415	115	19	w	w	PROPN
admet-2415	115	20	t	t	PROPN
admet-2415	116	1	k	k	PROPN
admet-2415	116	2	c	c	PROPN
admet-2415	116	3	t	t	PROPN
admet-2415	116	4	w	w	PROPN
admet-2415	116	5	t	t	PROPN
admet-2415	116	6	t	t	PROPN
admet-2415	116	7	=	=	SYM
admet-2415	116	8	,	,	PUNCT
admet-2415	116	9	w	w	PROPN
admet-2415	116	10			NUM
admet-2415	116	11	wb	wb	NOUN
admet-2415	116	12	;	;	PUNCT
admet-2415	116	13	(	(	PUNCT
admet-2415	116	14	)	)	PUNCT
admet-2415	116	15	(	(	PUNCT
admet-2415	116	16	)	)	PUNCT
admet-2415	116	17	(	(	PUNCT
admet-2415	116	18	)	)	SYM
admet-2415	116	19	1	1	NUM
admet-2415	116	20	d	d	SYM
admet-2415	116	21	1	1	NUM
admet-2415	116	22	d	d	NOUN
admet-2415	116	23	  	  	SPACE
admet-2415	116	24	2-	2-	NUM
admet-2415	116	25	  	  	SPACE
admet-2415	116	26	d	d	PROPN
admet-2415	116	27	w	w	PROPN
admet-2415	116	28	t	t	PROPN
admet-2415	117	1	k	k	PROPN
admet-2415	117	2	k	k	PROPN
admet-2415	117	3	c	c	PROPN
admet-2415	117	4	t	t	PROPN
admet-2415	117	5	w	w	PROPN
admet-2415	117	6	t	t	PROPN
admet-2415	117	7	t	t	PROPN
admet-2415	117	8	=	=	SYM
admet-2415	117	9	,	,	PUNCT
admet-2415	117	10	w	w	PROPN
admet-2415	117	11	>	>	X
admet-2415	117	12	wb	wb	PROPN
admet-2415	117	13	;	;	PUNCT
admet-2415	117	14	w1(0	w1(0	PROPN
admet-2415	117	15	)	)	PUNCT
admet-2415	117	16	=	=	PUNCT
admet-2415	117	17	w0	w0	PROPN
admet-2415	117	18	[	[	X
admet-2415	117	19	10	10	NUM
admet-2415	117	20	]	]	X
admet-2415	117	21	admet	admet	PROPN
admet-2415	117	22	&	&	CCONJ
admet-2415	117	23	dmpk	dmpk	PROPN
admet-2415	117	24	12(5	12(5	NUM
admet-2415	117	25	)	)	PUNCT
admet-2415	117	26	(	(	PUNCT
admet-2415	117	27	2024	2024	NUM
admet-2415	117	28	)	)	PUNCT
admet-2415	117	29	705	705	NUM
admet-2415	117	30	-	-	SYM
admet-2415	117	31	719	719	NUM
admet-2415	117	32	drug	drug	NOUN
admet-2415	117	33	delivery	delivery	NOUN
admet-2415	117	34	to	to	ADP
admet-2415	117	35	tumor	tumor	NOUN
admet-2415	117	36	by	by	ADP
admet-2415	117	37	nanoparticles	nanoparticle	NOUN
admet-2415	117	38	doi	doi	NOUN
admet-2415	117	39	:	:	PUNCT
admet-2415	117	40	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	117	41	709	709	NUM
admet-2415	117	42	where	where	SCONJ
admet-2415	117	43	w1	w1	NOUN
admet-2415	117	44	/	/	SYM
admet-2415	117	45	g	g	PROPN
admet-2415	117	46	describes	describe	VERB
admet-2415	117	47	the	the	DET
admet-2415	117	48	tumor	tumor	NOUN
admet-2415	117	49	weight	weight	NOUN
admet-2415	117	50	with	with	ADP
admet-2415	117	51	the	the	DET
admet-2415	117	52	initial	initial	ADJ
admet-2415	117	53	exponential	exponential	ADJ
admet-2415	117	54	growth	growth	NOUN
admet-2415	117	55	characterized	characterize	VERB
admet-2415	117	56	by	by	ADP
admet-2415	117	57	the	the	DET
admet-2415	117	58	rate	rate	NOUN
admet-2415	117	59	,	,	PUNCT
admet-2415	117	60	k1	k1	NOUN
admet-2415	117	61	,	,	PUNCT
admet-2415	117	62	followed	follow	VERB
admet-2415	117	63	by	by	ADP
admet-2415	117	64	the	the	DET
admet-2415	117	65	linear	linear	ADJ
admet-2415	117	66	growth	growth	NOUN
admet-2415	117	67	characterized	characterize	VERB
admet-2415	117	68	by	by	ADP
admet-2415	117	69	the	the	DET
admet-2415	117	70	rate	rate	NOUN
admet-2415	117	71	,	,	PUNCT
admet-2415	117	72	k2	k2	NOUN
admet-2415	117	73	,	,	PUNCT
admet-2415	117	74	and	and	CCONJ
admet-2415	117	75	wb	wb	PROPN
admet-2415	117	76	is	be	AUX
admet-2415	117	77	the	the	DET
admet-2415	117	78	weight	weight	NOUN
admet-2415	117	79	cutoff	cutoff	NOUN
admet-2415	117	80	above	above	ADP
admet-2415	117	81	which	which	PRON
admet-2415	117	82	the	the	DET
admet-2415	117	83	tumor	tumor	NOUN
admet-2415	117	84	growth	growth	NOUN
admet-2415	117	85	switches	switch	NOUN
admet-2415	117	86	from	from	ADP
admet-2415	117	87	the	the	DET
admet-2415	117	88	exponential	exponential	NOUN
admet-2415	117	89	to	to	ADP
admet-2415	117	90	a	a	DET
admet-2415	117	91	linear	linear	ADJ
admet-2415	117	92	model	model	NOUN
admet-2415	117	93	.	.	PUNCT
admet-2415	118	1	w0	w0	PROPN
admet-2415	118	2	represents	represent	VERB
admet-2415	118	3	the	the	DET
admet-2415	118	4	initial	initial	ADJ
admet-2415	118	5	tumor	tumor	NOUN
admet-2415	118	6	weight	weight	NOUN
admet-2415	118	7	,	,	PUNCT
admet-2415	118	8	and	and	CCONJ
admet-2415	118	9	kd	kd	PROPN
admet-2415	118	10	denotes	denote	VERB
admet-2415	118	11	the	the	DET
admet-2415	118	12	tumor	tumor	NOUN
admet-2415	118	13	cell	cell	NOUN
admet-2415	118	14	elimination	elimination	NOUN
admet-2415	118	15	rate	rate	NOUN
admet-2415	118	16	by	by	ADP
admet-2415	118	17	the	the	DET
admet-2415	118	18	drug	drug	NOUN
admet-2415	118	19	with	with	ADP
admet-2415	118	20	c	c	NOUN
admet-2415	118	21	denoting	denote	VERB
admet-2415	118	22	the	the	DET
admet-2415	118	23	drug	drug	NOUN
admet-2415	118	24	concentration	concentration	NOUN
admet-2415	118	25	,	,	PUNCT
admet-2415	118	26	which	which	PRON
admet-2415	118	27	is	be	AUX
admet-2415	118	28	calculated	calculate	VERB
admet-2415	118	29	by	by	ADP
admet-2415	118	30	the	the	DET
admet-2415	118	31	pk	pk	NOUN
admet-2415	118	32	model	model	NOUN
admet-2415	118	33	.	.	PUNCT
admet-2415	119	1	moreover	moreover	ADV
admet-2415	119	2	,	,	PUNCT
admet-2415	119	3	compartments	compartment	NOUN
admet-2415	119	4	w2	w2	NOUN
admet-2415	119	5	and	and	CCONJ
admet-2415	119	6	w3	w3	PROPN
admet-2415	119	7	are	be	AUX
admet-2415	119	8	introduced	introduce	VERB
admet-2415	119	9	to	to	PART
admet-2415	119	10	compensate	compensate	VERB
admet-2415	119	11	for	for	ADP
admet-2415	119	12	the	the	DET
admet-2415	119	13	lapse	lapse	NOUN
admet-2415	119	14	of	of	ADP
admet-2415	119	15	tumor	tumor	NOUN
admet-2415	119	16	growth	growth	NOUN
admet-2415	119	17	upon	upon	SCONJ
admet-2415	119	18	drug	drug	NOUN
admet-2415	119	19	exposure	exposure	NOUN
admet-2415	119	20	,	,	PUNCT
admet-2415	119	21	equations	equation	NOUN
admet-2415	119	22	(	(	PUNCT
admet-2415	119	23	11	11	NUM
admet-2415	119	24	)	)	PUNCT
admet-2415	119	25	to	to	ADP
admet-2415	119	26	(	(	PUNCT
admet-2415	119	27	15	15	NUM
admet-2415	119	28	)	)	PUNCT
admet-2415	119	29	:	:	PUNCT
admet-2415	119	30	(	(	PUNCT
admet-2415	119	31	)	)	PUNCT
admet-2415	119	32	(	(	PUNCT
admet-2415	119	33	)	)	PUNCT
admet-2415	119	34	(	(	PUNCT
admet-2415	119	35	)	)	PUNCT
admet-2415	119	36	(	(	PUNCT
admet-2415	119	37	)	)	SYM
admet-2415	119	38	2	2	NUM
admet-2415	119	39	d	d	SYM
admet-2415	119	40	1	1	NUM
admet-2415	119	41	2	2	NUM
admet-2415	119	42	d	d	NOUN
admet-2415	119	43	 	 	SPACE
admet-2415	119	44	=	=	PUNCT
admet-2415	119	45	-	-	PUNCT
admet-2415	119	46	  	  	SPACE
admet-2415	119	47	d	d	PROPN
admet-2415	119	48	w	w	PROPN
admet-2415	119	49	t	t	PROPN
admet-2415	120	1	k	k	PROPN
admet-2415	120	2	c	c	PROPN
admet-2415	120	3	t	t	PROPN
admet-2415	120	4	w	w	PROPN
admet-2415	120	5	t	t	PROPN
admet-2415	120	6	w	w	PROPN
admet-2415	120	7	t	t	PROPN
admet-2415	120	8	t	t	NOUN
admet-2415	120	9			NOUN
admet-2415	121	1	[	[	X
admet-2415	121	2	11	11	NUM
admet-2415	121	3	]	]	X
admet-2415	121	4	(	(	PUNCT
admet-2415	121	5	)	)	PUNCT
admet-2415	121	6	(	(	PUNCT
admet-2415	121	7	)	)	PUNCT
admet-2415	121	8	(	(	PUNCT
admet-2415	121	9	)	)	PUNCT
admet-2415	121	10	(	(	PUNCT
admet-2415	121	11	)	)	PUNCT
admet-2415	121	12	3	3	NUM
admet-2415	121	13	2	2	NUM
admet-2415	121	14	3	3	NUM
admet-2415	121	15	d	d	NOUN
admet-2415	121	16	 	 	SPACE
admet-2415	121	17	=	=	NOUN
admet-2415	121	18	  	  	SPACE
admet-2415	121	19	-	-	PUNCT
admet-2415	121	20	  	  	SPACE
admet-2415	121	21	d	d	PROPN
admet-2415	121	22	w	w	PROPN
admet-2415	121	23	t	t	PROPN
admet-2415	121	24	w	w	PROPN
admet-2415	121	25	t	t	PROPN
admet-2415	121	26	w	w	PROPN
admet-2415	121	27	t	t	PROPN
admet-2415	121	28	t	t	NOUN
admet-2415	121	29			NOUN
admet-2415	122	1	[	[	X
admet-2415	122	2	12	12	NUM
admet-2415	122	3	]	]	X
admet-2415	122	4	(	(	PUNCT
admet-2415	122	5	)	)	PUNCT
admet-2415	122	6	(	(	PUNCT
admet-2415	122	7	)	)	PUNCT
admet-2415	122	8	(	(	PUNCT
admet-2415	122	9	)	)	PUNCT
admet-2415	122	10	(	(	PUNCT
admet-2415	122	11	)	)	PUNCT
admet-2415	122	12	4	4	NUM
admet-2415	122	13	3	3	NUM
admet-2415	122	14	4	4	NUM
admet-2415	122	15	d	d	NOUN
admet-2415	122	16	 	 	SPACE
admet-2415	122	17	=	=	NOUN
admet-2415	122	18	  	  	SPACE
admet-2415	122	19	-	-	PUNCT
admet-2415	122	20	  	  	SPACE
admet-2415	122	21	d	d	PROPN
admet-2415	122	22	w	w	PROPN
admet-2415	122	23	t	t	PROPN
admet-2415	122	24	w	w	PROPN
admet-2415	122	25	t	t	PROPN
admet-2415	122	26	w	w	PROPN
admet-2415	122	27	t	t	PROPN
admet-2415	122	28	t	t	NOUN
admet-2415	122	29			NOUN
admet-2415	122	30	[	[	X
admet-2415	122	31	13	13	NUM
admet-2415	122	32	]	]	PUNCT
admet-2415	122	33	w(t	w(t	PROPN
admet-2415	122	34	)	)	PUNCT
admet-2415	123	1	=	=	SYM
admet-2415	123	2	w2(t	w2(t	PROPN
admet-2415	123	3	)	)	PUNCT
admet-2415	124	1	+	+	CCONJ
admet-2415	124	2	w2(t	w2(t	PROPN
admet-2415	124	3	)	)	PUNCT
admet-2415	125	1	+	+	CCONJ
admet-2415	125	2	w3(t	w3(t	NUM
admet-2415	125	3	)	)	PUNCT
admet-2415	125	4	+	+	CCONJ
admet-2415	126	1	w4(t	w4(t	X
admet-2415	126	2	)	)	PUNCT
admet-2415	127	1	[	[	X
admet-2415	127	2	14	14	NUM
admet-2415	127	3	]	]	X
admet-2415	127	4	w1(0	w1(0	PROPN
admet-2415	127	5	)	)	PUNCT
admet-2415	127	6	=	=	SYM
admet-2415	127	7	w0	w0	PROPN
admet-2415	127	8	,	,	PUNCT
admet-2415	127	9	w2(0	w2(0	ADJ
admet-2415	127	10	)	)	PUNCT
admet-2415	127	11	=	=	SYM
admet-2415	127	12	w3(0	w3(0	PROPN
admet-2415	127	13	)	)	PUNCT
admet-2415	127	14	=	=	SYM
admet-2415	127	15	w4(0	w4(0	NOUN
admet-2415	127	16	)	)	PUNCT
admet-2415	127	17	=	=	SYM
admet-2415	127	18	0	0	PUNCT
admet-2415	128	1	[	[	X
admet-2415	128	2	15	15	NUM
admet-2415	128	3	]	]	PUNCT
admet-2415	128	4	where	where	SCONJ
admet-2415	128	5	w	w	NOUN
admet-2415	128	6	is	be	AUX
admet-2415	128	7	the	the	DET
admet-2415	128	8	total	total	ADJ
admet-2415	128	9	tumor	tumor	NOUN
admet-2415	128	10	weight	weight	NOUN
admet-2415	128	11	and	and	CCONJ
admet-2415	128	12			NOUN
admet-2415	128	13	is	be	AUX
admet-2415	128	14	the	the	DET
admet-2415	128	15	transit	transit	NOUN
admet-2415	128	16	parameter	parameter	NOUN
admet-2415	128	17	to	to	PART
admet-2415	128	18	define	define	VERB
admet-2415	128	19	the	the	DET
admet-2415	128	20	treatment	treatment	NOUN
admet-2415	128	21	lapse	lapse	NOUN
admet-2415	128	22	.	.	PUNCT
admet-2415	129	1	in	in	ADP
admet-2415	129	2	this	this	DET
admet-2415	129	3	study	study	NOUN
admet-2415	129	4	,	,	PUNCT
admet-2415	129	5	nls	nls	PROPN
admet-2415	129	6	was	be	AUX
admet-2415	129	7	first	first	ADV
admet-2415	129	8	applied	apply	VERB
admet-2415	129	9	to	to	PART
admet-2415	129	10	fit	fit	VERB
admet-2415	129	11	the	the	DET
admet-2415	129	12	model	model	NOUN
admet-2415	129	13	against	against	ADP
admet-2415	129	14	experimental	experimental	ADJ
admet-2415	129	15	data	datum	NOUN
admet-2415	129	16	of	of	ADP
admet-2415	129	17	tumor	tumor	NOUN
admet-2415	129	18	weight	weight	NOUN
admet-2415	129	19	of	of	ADP
admet-2415	129	20	mice	mouse	NOUN
admet-2415	129	21	treated	treat	VERB
admet-2415	129	22	with	with	ADP
admet-2415	129	23	saline	saline	NOUN
admet-2415	129	24	and	and	CCONJ
admet-2415	129	25	obtain	obtain	VERB
admet-2415	129	26	the	the	DET
admet-2415	129	27	tumor	tumor	NOUN
admet-2415	129	28	growth	growth	NOUN
admet-2415	129	29	factors	factor	NOUN
admet-2415	129	30	(	(	PUNCT
admet-2415	129	31	k	k	NOUN
admet-2415	129	32	values	value	NOUN
admet-2415	129	33	and	and	CCONJ
admet-2415	129	34			NOUN
admet-2415	129	35	)	)	PUNCT
admet-2415	129	36	.	.	PUNCT
admet-2415	130	1	sensitivity	sensitivity	NOUN
admet-2415	130	2	analysis	analysis	NOUN
admet-2415	130	3	and	and	CCONJ
admet-2415	130	4	scaling	scale	VERB
admet-2415	130	5	to	to	ADP
admet-2415	130	6	human	human	NOUN
admet-2415	130	7	to	to	PART
admet-2415	130	8	quantitatively	quantitatively	ADV
admet-2415	130	9	assess	assess	VERB
admet-2415	130	10	the	the	DET
admet-2415	130	11	relative	relative	ADJ
admet-2415	130	12	importance	importance	NOUN
admet-2415	130	13	of	of	ADP
admet-2415	130	14	each	each	DET
admet-2415	130	15	pbpk	pbpk	ADJ
admet-2415	130	16	parameter	parameter	NOUN
admet-2415	130	17	that	that	PRON
admet-2415	130	18	was	be	AUX
admet-2415	130	19	obtained	obtain	VERB
admet-2415	130	20	from	from	ADP
admet-2415	130	21	nls	nls	NOUN
admet-2415	130	22	fitting	fit	VERB
admet-2415	130	23	on	on	ADP
admet-2415	130	24	the	the	DET
admet-2415	130	25	pk	pk	NOUN
admet-2415	130	26	and	and	CCONJ
admet-2415	130	27	biodistribution	biodistribution	NOUN
admet-2415	130	28	of	of	ADP
admet-2415	130	29	drug	drug	NOUN
admet-2415	130	30	treatment	treatment	NOUN
admet-2415	130	31	,	,	PUNCT
admet-2415	130	32	a	a	DET
admet-2415	130	33	sensitivity	sensitivity	NOUN
admet-2415	130	34	analysis	analysis	NOUN
admet-2415	130	35	was	be	AUX
admet-2415	130	36	conducted	conduct	VERB
admet-2415	130	37	.	.	PUNCT
admet-2415	131	1	according	accord	VERB
admet-2415	131	2	to	to	ADP
admet-2415	131	3	our	our	PRON
admet-2415	131	4	pbpk	pbpk	ADJ
admet-2415	131	5	model	model	NOUN
admet-2415	131	6	,	,	PUNCT
admet-2415	131	7	drug	drug	NOUN
admet-2415	131	8	distribution	distribution	NOUN
admet-2415	131	9	and	and	CCONJ
admet-2415	131	10	accumulation	accumulation	NOUN
admet-2415	131	11	mainly	mainly	ADV
admet-2415	131	12	depend	depend	VERB
admet-2415	131	13	on	on	ADP
admet-2415	131	14	blood	blood	NOUN
admet-2415	131	15	flow	flow	NOUN
admet-2415	131	16	rate	rate	NOUN
admet-2415	131	17	,	,	PUNCT
admet-2415	131	18	tissue	tissue	NOUN
admet-2415	131	19	partition	partition	NOUN
admet-2415	131	20	coefficient	coefficient	NOUN
admet-2415	131	21	,	,	PUNCT
admet-2415	131	22	and	and	CCONJ
admet-2415	131	23	renal	renal	ADJ
admet-2415	131	24	clearance	clearance	NOUN
admet-2415	131	25	.	.	PUNCT
admet-2415	132	1	derivative	derivative	ADJ
admet-2415	132	2	-	-	PUNCT
admet-2415	132	3	based	base	VERB
admet-2415	132	4	local	local	ADJ
admet-2415	132	5	sensitivity	sensitivity	NOUN
admet-2415	132	6	was	be	AUX
admet-2415	132	7	performed	perform	VERB
admet-2415	132	8	by	by	ADP
admet-2415	132	9	applying	apply	VERB
admet-2415	132	10	the	the	DET
admet-2415	132	11	one	one	NUM
admet-2415	132	12	-	-	PUNCT
admet-2415	132	13	at	at	ADP
admet-2415	132	14	-	-	PUNCT
admet-2415	132	15	a	a	DET
admet-2415	132	16	-	-	PUNCT
admet-2415	132	17	time	time	NOUN
admet-2415	132	18	(	(	PUNCT
admet-2415	132	19	oat	oat	NOUN
admet-2415	132	20	)	)	PUNCT
admet-2415	132	21	technique	technique	NOUN
admet-2415	132	22	to	to	PART
admet-2415	132	23	evaluate	evaluate	VERB
admet-2415	132	24	the	the	DET
admet-2415	132	25	effect	effect	NOUN
admet-2415	132	26	of	of	ADP
admet-2415	132	27	one	one	NUM
admet-2415	132	28	parameter	parameter	NOUN
admet-2415	132	29	on	on	ADP
admet-2415	132	30	drug	drug	NOUN
admet-2415	132	31	concentrations	concentration	NOUN
admet-2415	132	32	in	in	ADP
admet-2415	132	33	organs	organ	NOUN
admet-2415	132	34	while	while	SCONJ
admet-2415	132	35	keeping	keep	VERB
admet-2415	132	36	other	other	ADJ
admet-2415	132	37	parameters	parameter	NOUN
admet-2415	132	38	fixed	fix	VERB
admet-2415	132	39	[	[	X
admet-2415	132	40	31,32	31,32	NUM
admet-2415	132	41	]	]	X
admet-2415	132	42	.	.	PUNCT
admet-2415	133	1	specifically	specifically	ADV
admet-2415	133	2	,	,	PUNCT
admet-2415	133	3	sensitivity	sensitivity	NOUN
admet-2415	133	4	is	be	AUX
admet-2415	133	5	calculated	calculate	VERB
admet-2415	133	6	by	by	ADP
admet-2415	133	7	taking	take	VERB
admet-2415	133	8	the	the	DET
admet-2415	133	9	derivative	derivative	NOUN
admet-2415	133	10	of	of	ADP
admet-2415	133	11	a	a	DET
admet-2415	133	12	particular	particular	ADJ
admet-2415	133	13	output	output	NOUN
admet-2415	133	14	(	(	PUNCT
admet-2415	133	15	e.g.	e.g.	ADV
admet-2415	133	16	drug	drug	NOUN
admet-2415	133	17	concentration	concentration	NOUN
admet-2415	133	18	in	in	ADP
admet-2415	133	19	the	the	DET
admet-2415	133	20	liver	liver	NOUN
admet-2415	133	21	)	)	PUNCT
admet-2415	133	22	over	over	ADP
admet-2415	133	23	the	the	DET
admet-2415	133	24	parameter	parameter	NOUN
admet-2415	133	25	of	of	ADP
admet-2415	133	26	interest	interest	NOUN
admet-2415	133	27	(	(	PUNCT
admet-2415	133	28	e.g.	e.g.	ADV
admet-2415	133	29	clearance	clearance	NOUN
admet-2415	133	30	)	)	PUNCT
admet-2415	133	31	,	,	PUNCT
admet-2415	133	32	equation	equation	NOUN
admet-2415	133	33	(	(	PUNCT
admet-2415	133	34	16	16	NUM
admet-2415	133	35	):	):	PUNCT
admet-2415	133	36	output	output	NOUN
admet-2415	133	37	sensitivity	sensitivity	NOUN
admet-2415	133	38	parameter	parameter	NOUN
admet-2415	133	39			PROPN
admet-2415	133	40	=	=	SYM
admet-2415	133	41			PROPN
admet-2415	133	42	[	[	X
admet-2415	133	43	16	16	NUM
admet-2415	133	44	]	]	PUNCT
admet-2415	133	45	as	as	SCONJ
admet-2415	133	46	the	the	DET
admet-2415	133	47	output	output	NOUN
admet-2415	133	48	(	(	PUNCT
admet-2415	133	49	i.e.	i.e.	X
admet-2415	133	50	concentration	concentration	NOUN
admet-2415	133	51	)	)	PUNCT
admet-2415	133	52	is	be	AUX
admet-2415	133	53	a	a	DET
admet-2415	133	54	function	function	NOUN
admet-2415	133	55	of	of	ADP
admet-2415	133	56	time	time	NOUN
admet-2415	133	57	,	,	PUNCT
admet-2415	133	58	a	a	DET
admet-2415	133	59	calculated	calculated	ADJ
admet-2415	133	60	sensitivity	sensitivity	NOUN
admet-2415	133	61	is	be	AUX
admet-2415	133	62	then	then	ADV
admet-2415	133	63	integrated	integrate	VERB
admet-2415	133	64	over	over	ADP
admet-2415	133	65	the	the	DET
admet-2415	133	66	treatment	treatment	NOUN
admet-2415	133	67	time	time	NOUN
admet-2415	133	68	.	.	PUNCT
admet-2415	134	1	all	all	DET
admet-2415	134	2	the	the	DET
admet-2415	134	3	sensitivity	sensitivity	NOUN
admet-2415	134	4	values	value	NOUN
admet-2415	134	5	are	be	AUX
admet-2415	134	6	assembled	assemble	VERB
admet-2415	134	7	into	into	ADP
admet-2415	134	8	a	a	DET
admet-2415	134	9	final	final	ADJ
admet-2415	134	10	sensitivity	sensitivity	NOUN
admet-2415	134	11	matrix	matrix	NOUN
admet-2415	134	12	for	for	ADP
admet-2415	134	13	reporting	report	VERB
admet-2415	134	14	with	with	ADP
admet-2415	134	15	the	the	DET
admet-2415	134	16	output	output	NOUN
admet-2415	134	17	properties	property	NOUN
admet-2415	134	18	(	(	PUNCT
admet-2415	134	19	i.e.	i.e.	X
admet-2415	134	20	concentrations	concentration	NOUN
admet-2415	134	21	in	in	ADP
admet-2415	134	22	all	all	DET
admet-2415	134	23	respective	respective	ADJ
admet-2415	134	24	organs	organ	NOUN
admet-2415	134	25	)	)	PUNCT
admet-2415	134	26	and	and	CCONJ
admet-2415	134	27	pbpk	pbpk	NOUN
admet-2415	134	28	parameters	parameter	NOUN
admet-2415	134	29	marked	mark	VERB
admet-2415	134	30	.	.	PUNCT
admet-2415	135	1	finally	finally	ADV
admet-2415	135	2	,	,	PUNCT
admet-2415	135	3	the	the	DET
admet-2415	135	4	pbpk	pbpk	ADJ
admet-2415	135	5	model	model	NOUN
admet-2415	135	6	was	be	AUX
admet-2415	135	7	scaled	scale	VERB
admet-2415	135	8	to	to	ADP
admet-2415	135	9	humans	human	NOUN
admet-2415	135	10	,	,	PUNCT
admet-2415	135	11	and	and	CCONJ
admet-2415	135	12	pk	pk	NOUN
admet-2415	135	13	simulation	simulation	NOUN
admet-2415	135	14	was	be	AUX
admet-2415	135	15	conducted	conduct	VERB
admet-2415	135	16	.	.	PUNCT
admet-2415	136	1	we	we	PRON
admet-2415	136	2	assumed	assume	VERB
admet-2415	136	3	that	that	SCONJ
admet-2415	136	4	organ	organ	NOUN
admet-2415	136	5	partitioning	partitioning	NOUN
admet-2415	136	6	of	of	ADP
admet-2415	136	7	ptx	ptx	NOUN
admet-2415	136	8	ncs	ncs	PROPN
admet-2415	136	9	is	be	AUX
admet-2415	136	10	similar	similar	ADJ
admet-2415	136	11	between	between	ADP
admet-2415	136	12	mice	mouse	NOUN
admet-2415	136	13	and	and	CCONJ
admet-2415	136	14	humans	human	NOUN
admet-2415	136	15	.	.	PUNCT
admet-2415	137	1	to	to	PART
admet-2415	137	2	do	do	VERB
admet-2415	137	3	this	this	PRON
admet-2415	137	4	,	,	PUNCT
admet-2415	137	5	physiological	physiological	ADJ
admet-2415	137	6	data	datum	NOUN
admet-2415	137	7	was	be	AUX
admet-2415	137	8	replaced	replace	VERB
admet-2415	137	9	by	by	ADP
admet-2415	137	10	human	human	ADJ
admet-2415	137	11	values	value	NOUN
admet-2415	137	12	taken	take	VERB
admet-2415	137	13	from	from	ADP
admet-2415	137	14	literature	literature	NOUN
admet-2415	137	15	[	[	X
admet-2415	137	16	22,33	22,33	NUM
admet-2415	137	17	]	]	PUNCT
admet-2415	137	18	,	,	PUNCT
admet-2415	137	19	shown	show	VERB
admet-2415	137	20	in	in	ADP
admet-2415	137	21	table	table	NOUN
admet-2415	137	22	2	2	NUM
admet-2415	137	23	.	.	PUNCT
admet-2415	138	1	the	the	DET
admet-2415	138	2	clearance	clearance	NOUN
admet-2415	138	3	of	of	ADP
admet-2415	138	4	the	the	DET
admet-2415	138	5	drug	drug	NOUN
admet-2415	138	6	was	be	AUX
admet-2415	138	7	also	also	ADV
admet-2415	138	8	replaced	replace	VERB
admet-2415	138	9	with	with	ADP
admet-2415	138	10	that	that	PRON
admet-2415	138	11	in	in	ADP
admet-2415	138	12	humans	human	NOUN
admet-2415	138	13	[	[	X
admet-2415	138	14	34	34	NUM
admet-2415	138	15	]	]	PUNCT
admet-2415	138	16	.	.	PUNCT
admet-2415	139	1	note	note	VERB
admet-2415	139	2	that	that	SCONJ
admet-2415	139	3	the	the	DET
admet-2415	139	4	tumor	tumor	NOUN
admet-2415	139	5	data	datum	NOUN
admet-2415	139	6	was	be	AUX
admet-2415	139	7	of	of	ADP
admet-2415	139	8	breast	breast	NOUN
admet-2415	139	9	tumor	tumor	NOUN
admet-2415	139	10	,	,	PUNCT
admet-2415	139	11	and	and	CCONJ
admet-2415	139	12	its	its	PRON
admet-2415	139	13	plasma	plasma	NOUN
admet-2415	139	14	flow	flow	NOUN
admet-2415	139	15	was	be	AUX
admet-2415	139	16	determined	determine	VERB
admet-2415	139	17	by	by	ADP
admet-2415	139	18	macroscopic	macroscopic	ADJ
admet-2415	139	19	approaches	approach	NOUN
admet-2415	139	20	[	[	X
admet-2415	139	21	35	35	NUM
admet-2415	139	22	]	]	PUNCT
admet-2415	139	23	.	.	PUNCT
admet-2415	140	1	table	table	NOUN
admet-2415	140	2	2	2	NUM
admet-2415	140	3	.	.	PUNCT
admet-2415	140	4	physiological	physiological	ADJ
admet-2415	140	5	parameters	parameter	NOUN
admet-2415	140	6	used	use	VERB
admet-2415	140	7	for	for	ADP
admet-2415	140	8	humans	human	NOUN
admet-2415	140	9	(	(	PUNCT
admet-2415	140	10	70	70	NUM
admet-2415	140	11	kg	kg	NOUN
admet-2415	140	12	)	)	PUNCT
admet-2415	140	13	.	.	PUNCT
admet-2415	141	1	tissue	tissue	NOUN
admet-2415	141	2	plasma	plasma	NOUN
admet-2415	141	3	flow	flow	NOUN
admet-2415	141	4	,	,	PUNCT
admet-2415	141	5	l	l	NOUN
admet-2415	141	6	/	/	SYM
admet-2415	141	7	h	h	NOUN
admet-2415	141	8	organ	organ	NOUN
admet-2415	141	9	volume	volume	NOUN
admet-2415	141	10	,	,	PUNCT
admet-2415	141	11	l	l	NOUN
admet-2415	141	12	blood	blood	NOUN
admet-2415	141	13	336	336	NUM
admet-2415	142	1	5.2ǂ	5.2ǂ	NOUN
admet-2415	142	2	liver	liver	NOUN
admet-2415	142	3	87	87	NUM
admet-2415	142	4	1.69ǂ	1.69ǂ	NUM
admet-2415	142	5	spleen	spleen	NOUN
admet-2415	142	6	4.62	4.62	NUM
admet-2415	142	7	0.192ǂ	0.192ǂ	NUM
admet-2415	142	8	heart	heart	NOUN
admet-2415	142	9	14.4	14.4	NUM
admet-2415	142	10	0.31ǂ	0.31ǂ	NUM
admet-2415	142	11	lung	lung	NOUN
admet-2415	142	12	336	336	NUM
admet-2415	142	13	1.17ǂ	1.17ǂ	NUM
admet-2415	142	14	kidney	kidney	NOUN
admet-2415	142	15	74.4	74.4	NUM
admet-2415	142	16	0.28ǂ	0.28ǂ	NOUN
admet-2415	142	17	tumor	tumor	NOUN
admet-2415	142	18	3.2	3.2	NUM
admet-2415	142	19	0.00419ǂ	0.00419ǂ	NOUN
admet-2415	142	20	remainder	remainder	VERB
admet-2415	142	21	157	157	NUM
admet-2415	142	22	55.9	55.9	NUM
admet-2415	142	23	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	142	24	s.	s.	PROPN
admet-2415	142	25	lu	lu	PROPN
admet-2415	142	26	et	et	PROPN
admet-2415	142	27	al	al	PROPN
admet-2415	142	28	.	.	PROPN
admet-2415	142	29	admet	admet	PROPN
admet-2415	142	30	&	&	CCONJ
admet-2415	142	31	dmpk	dmpk	PROPN
admet-2415	142	32	12(5	12(5	NUM
admet-2415	142	33	)	)	PUNCT
admet-2415	142	34	(	(	PUNCT
admet-2415	142	35	2024	2024	NUM
admet-2415	142	36	)	)	PUNCT
admet-2415	142	37	705	705	NUM
admet-2415	142	38	-	-	SYM
admet-2415	142	39	719	719	NUM
admet-2415	142	40	710	710	NUM
admet-2415	142	41	tissue	tissue	NOUN
admet-2415	142	42	plasma	plasma	NOUN
admet-2415	142	43	flow	flow	NOUN
admet-2415	142	44	,	,	PUNCT
admet-2415	142	45	l	l	NOUN
admet-2415	142	46	/	/	SYM
admet-2415	142	47	h	h	NOUN
admet-2415	142	48	organ	organ	NOUN
admet-2415	142	49	volume	volume	NOUN
admet-2415	142	50	,	,	PUNCT
admet-2415	142	51	l	l	PROPN
admet-2415	142	52	hepatic	hepatic	ADJ
admet-2415	142	53	flow	flow	NOUN
admet-2415	142	54	rate	rate	NOUN
admet-2415	142	55	82.38	82.38	NUM
admet-2415	142	56	ǂorgan	ǂorgan	NOUN
admet-2415	142	57	volume	volume	NOUN
admet-2415	142	58	was	be	AUX
admet-2415	142	59	obtained	obtain	VERB
admet-2415	142	60	from	from	ADP
admet-2415	142	61	the	the	DET
admet-2415	142	62	literature	literature	NOUN
admet-2415	143	1	[	[	X
admet-2415	143	2	22	22	NUM
admet-2415	143	3	,	,	PUNCT
admet-2415	143	4	33	33	NUM
admet-2415	143	5	]	]	PUNCT
admet-2415	143	6	.	.	PUNCT
admet-2415	144	1	results	result	NOUN
admet-2415	144	2	and	and	CCONJ
admet-2415	144	3	discussion	discussion	NOUN
admet-2415	144	4	pbpk	pbpk	NOUN
admet-2415	144	5	modeling	modeling	NOUN
admet-2415	144	6	in	in	ADP
admet-2415	144	7	our	our	PRON
admet-2415	144	8	previous	previous	ADJ
admet-2415	144	9	studies	study	NOUN
admet-2415	144	10	with	with	ADP
admet-2415	144	11	paclitaxel	paclitaxel	PROPN
admet-2415	144	12	(	(	PUNCT
admet-2415	144	13	ptx	ptx	NOUN
admet-2415	144	14	)	)	PUNCT
admet-2415	144	15	nanocrystals	nanocrystal	NOUN
admet-2415	144	16	,	,	PUNCT
admet-2415	144	17	pk	pk	NOUN
admet-2415	144	18	and	and	CCONJ
admet-2415	144	19	pd	pd	PROPN
admet-2415	144	20	kinetics	kinetic	NOUN
admet-2415	144	21	were	be	AUX
admet-2415	144	22	determined	determine	VERB
admet-2415	144	23	in	in	ADP
admet-2415	144	24	tumorbearing	tumorbeare	VERB
admet-2415	144	25	mice	mouse	NOUN
admet-2415	145	1	[	[	X
admet-2415	145	2	10,11	10,11	NOUN
admet-2415	145	3	]	]	PUNCT
admet-2415	145	4	.	.	PUNCT
admet-2415	146	1	the	the	DET
admet-2415	146	2	murine	murine	ADJ
admet-2415	146	3	tumor	tumor	NOUN
admet-2415	146	4	model	model	NOUN
admet-2415	146	5	was	be	AUX
admet-2415	146	6	established	establish	VERB
admet-2415	146	7	by	by	ADP
admet-2415	146	8	subcutaneous	subcutaneous	ADJ
admet-2415	146	9	injection	injection	NOUN
admet-2415	146	10	of	of	ADP
admet-2415	146	11	3×106	3×106	NUM
admet-2415	146	12	ht-29	ht-29	PUNCT
admet-2415	146	13	cells	cell	NOUN
admet-2415	146	14	under	under	ADP
admet-2415	146	15	the	the	DET
admet-2415	146	16	right	right	ADJ
admet-2415	146	17	arm	arm	NOUN
admet-2415	146	18	and	and	CCONJ
admet-2415	146	19	3×106	3×106	NUM
admet-2415	147	1	kb	kb	NOUN
admet-2415	147	2	cells	cell	NOUN
admet-2415	147	3	under	under	ADP
admet-2415	147	4	the	the	DET
admet-2415	147	5	left	left	ADJ
admet-2415	147	6	arm	arm	NOUN
admet-2415	147	7	of	of	ADP
admet-2415	147	8	female	female	ADJ
admet-2415	147	9	nude	nude	ADJ
admet-2415	147	10	outbred	outbred	ADJ
admet-2415	147	11	mice	mouse	NOUN
admet-2415	147	12	.	.	PUNCT
admet-2415	148	1	taxol	taxol	PROPN
admet-2415	148	2	,	,	PUNCT
admet-2415	148	3	pure	pure	ADJ
admet-2415	148	4	ptx	ptx	NOUN
admet-2415	148	5	nanocrystals	nanocrystal	NOUN
admet-2415	148	6	and	and	CCONJ
admet-2415	148	7	ptx	ptx	VERB
admet-2415	148	8	nanocrystal	nanocrystal	ADJ
admet-2415	148	9	surface	surface	NOUN
admet-2415	148	10	-	-	PUNCT
admet-2415	148	11	coated	coat	VERB
admet-2415	148	12	with	with	ADP
admet-2415	148	13	f68	f68	PROPN
admet-2415	148	14	were	be	AUX
admet-2415	148	15	administered	administer	VERB
admet-2415	148	16	intravenously	intravenously	ADV
admet-2415	148	17	once	once	ADV
admet-2415	148	18	at	at	ADP
admet-2415	148	19	an	an	DET
admet-2415	148	20	equivalent	equivalent	ADJ
admet-2415	148	21	dose	dose	NOUN
admet-2415	148	22	of	of	ADP
admet-2415	148	23	20	20	NUM
admet-2415	148	24	mg	mg	PROPN
admet-2415	148	25	/	/	SYM
admet-2415	148	26	kg	kg	NOUN
admet-2415	148	27	via	via	ADP
admet-2415	148	28	the	the	DET
admet-2415	148	29	tail	tail	NOUN
admet-2415	148	30	vein	vein	NOUN
admet-2415	148	31	.	.	PUNCT
admet-2415	149	1	biodistribution	biodistribution	NOUN
admet-2415	149	2	and	and	CCONJ
admet-2415	149	3	pharmacokinetics	pharmacokinetic	NOUN
admet-2415	149	4	were	be	AUX
admet-2415	149	5	measured	measure	VERB
admet-2415	149	6	.	.	PUNCT
admet-2415	150	1	by	by	ADP
admet-2415	150	2	fitting	fit	VERB
admet-2415	150	3	the	the	DET
admet-2415	150	4	data	datum	NOUN
admet-2415	150	5	with	with	ADP
admet-2415	150	6	our	our	PRON
admet-2415	150	7	pbpk	pbpk	ADJ
admet-2415	150	8	model	model	NOUN
admet-2415	150	9	,	,	PUNCT
admet-2415	150	10	partition	partition	NOUN
admet-2415	150	11	coefficients	coefficient	NOUN
admet-2415	150	12	in	in	ADP
admet-2415	150	13	the	the	DET
admet-2415	150	14	major	major	ADJ
admet-2415	150	15	organs	organ	NOUN
admet-2415	150	16	and	and	CCONJ
admet-2415	150	17	the	the	DET
admet-2415	150	18	liver	liver	NOUN
admet-2415	150	19	clearance	clearance	NOUN
admet-2415	150	20	were	be	AUX
admet-2415	150	21	obtained	obtain	VERB
admet-2415	150	22	(	(	PUNCT
admet-2415	150	23	table	table	NOUN
admet-2415	150	24	3	3	NUM
admet-2415	150	25	)	)	PUNCT
admet-2415	150	26	.	.	PUNCT
admet-2415	151	1	the	the	DET
admet-2415	151	2	fit	fit	ADJ
admet-2415	151	3	lines	line	NOUN
admet-2415	151	4	are	be	AUX
admet-2415	151	5	shown	show	VERB
admet-2415	151	6	in	in	ADP
admet-2415	151	7	figure	figure	NOUN
admet-2415	151	8	2	2	NUM
admet-2415	151	9	.	.	PUNCT
admet-2415	151	10	table	table	NOUN
admet-2415	151	11	3	3	NUM
admet-2415	151	12	.	.	PUNCT
admet-2415	151	13	estimated	estimate	VERB
admet-2415	151	14	pharmacokinetic	pharmacokinetic	ADJ
admet-2415	151	15	parameters	parameter	NOUN
admet-2415	151	16	of	of	ADP
admet-2415	151	17	three	three	NUM
admet-2415	151	18	formulations	formulation	NOUN
admet-2415	151	19	of	of	ADP
admet-2415	151	20	paclitaxel	paclitaxel	PROPN
admet-2415	151	21	.	.	PUNCT
admet-2415	152	1	partition	partition	NOUN
admet-2415	152	2	coefficient	coefficient	PROPN
admet-2415	152	3	taxol	taxol	PROPN
admet-2415	152	4	cv	cv	PROPN
admet-2415	152	5	*	*	PROPN
admet-2415	152	6	,	,	PUNCT
admet-2415	152	7	%	%	INTJ
admet-2415	152	8	ptx	ptx	PROPN
admet-2415	152	9	-	-	PROPN
admet-2415	152	10	nc	nc	PROPN
admet-2415	152	11	cv	cv	PROPN
admet-2415	152	12	*	*	PROPN
admet-2415	152	13	,	,	PUNCT
admet-2415	152	14	%	%	INTJ
admet-2415	152	15	f68	f68	ADJ
admet-2415	152	16	-	-	PUNCT
admet-2415	152	17	ptx	ptx	NOUN
admet-2415	152	18	-	-	PROPN
admet-2415	152	19	nc	nc	PROPN
admet-2415	152	20	cv	cv	PROPN
admet-2415	152	21	*	*	PROPN
admet-2415	152	22	,	,	PUNCT
admet-2415	152	23	%	%	INTJ
admet-2415	152	24	kli	kli	PROPN
admet-2415	152	25	2.15	2.15	NUM
admet-2415	152	26	23.64	23.64	NUM
admet-2415	152	27	10.99	10.99	NUM
admet-2415	152	28	19.98	19.98	NUM
admet-2415	152	29	6.92	6.92	NUM
admet-2415	152	30	7.95	7.95	NUM
admet-2415	152	31	ksp	ksp	NOUN
admet-2415	152	32	0.13	0.13	NUM
admet-2415	152	33	9.79	9.79	NUM
admet-2415	152	34	1.04	1.04	NUM
admet-2415	152	35	35.63	35.63	NUM
admet-2415	152	36	0.32	0.32	NUM
admet-2415	152	37	15.61	15.61	NUM
admet-2415	152	38	kht	kht	NOUN
admet-2415	152	39	0.17	0.17	NUM
admet-2415	152	40	9.86	9.86	NUM
admet-2415	152	41	0.26	0.26	NUM
admet-2415	152	42	7.12	7.12	NUM
admet-2415	152	43	0.036	0.036	NUM
admet-2415	152	44	9.11	9.11	NUM
admet-2415	152	45	kkd	kkd	NOUN
admet-2415	152	46	0.75	0.75	NUM
admet-2415	152	47	12.06	12.06	NUM
admet-2415	152	48	0.41	0.41	NUM
admet-2415	152	49	17.02	17.02	NUM
admet-2415	152	50	0.18	0.18	NUM
admet-2415	152	51	10.67	10.67	NUM
admet-2415	152	52	klu	klu	PROPN
admet-2415	152	53	0.21	0.21	NUM
admet-2415	152	54	9.98	9.98	NUM
admet-2415	152	55	0.58	0.58	NUM
admet-2415	152	56	20.43	20.43	NUM
admet-2415	152	57	0.25	0.25	NUM
admet-2415	152	58	0.0012	0.0012	NUM
admet-2415	152	59	ktu	ktu	NOUN
admet-2415	152	60	0.27	0.27	NUM
admet-2415	152	61	14.35	14.35	NUM
admet-2415	152	62	0.28	0.28	NUM
admet-2415	152	63	19.00	19.00	NUM
admet-2415	152	64	0.65	0.65	NUM
admet-2415	152	65	23.43	23.43	NUM
admet-2415	152	66	clearance	clearance	NOUN
admet-2415	152	67	,	,	PUNCT
admet-2415	152	68	l	l	NOUN
admet-2415	152	69	/	/	SYM
admet-2415	152	70	h	h	NOUN
admet-2415	152	71	0.0023	0.0023	NUM
admet-2415	152	72	0.06	0.06	NUM
admet-2415	152	73	0.0026	0.0026	NUM
admet-2415	152	74	0.0052	0.0052	NUM
admet-2415	152	75	0.000091	0.000091	NUM
admet-2415	152	76	0.00083	0.00083	PUNCT
admet-2415	153	1	*	*	PUNCT
admet-2415	153	2	coefficient	coefficient	NOUN
admet-2415	153	3	of	of	ADP
admet-2415	153	4	variation	variation	NOUN
admet-2415	153	5	among	among	ADP
admet-2415	153	6	all	all	DET
admet-2415	153	7	compartments	compartment	NOUN
admet-2415	153	8	,	,	PUNCT
admet-2415	153	9	the	the	DET
admet-2415	153	10	partition	partition	NOUN
admet-2415	153	11	coefficient	coefficient	NOUN
admet-2415	153	12	of	of	ADP
admet-2415	153	13	the	the	DET
admet-2415	153	14	liver	liver	NOUN
admet-2415	153	15	is	be	AUX
admet-2415	153	16	the	the	DET
admet-2415	153	17	highest	high	ADJ
admet-2415	153	18	for	for	ADP
admet-2415	153	19	all	all	DET
admet-2415	153	20	three	three	NUM
admet-2415	153	21	delivery	delivery	NOUN
admet-2415	153	22	forms	form	NOUN
admet-2415	153	23	.	.	PUNCT
admet-2415	154	1	compared	compare	VERB
admet-2415	154	2	to	to	ADP
admet-2415	154	3	the	the	DET
admet-2415	154	4	conventional	conventional	ADJ
admet-2415	154	5	taxol	taxol	PROPN
admet-2415	154	6	delivery	delivery	NOUN
admet-2415	154	7	system	system	NOUN
admet-2415	154	8	,	,	PUNCT
admet-2415	154	9	the	the	DET
admet-2415	154	10	partition	partition	NOUN
admet-2415	154	11	coefficients	coefficient	VERB
admet-2415	154	12	for	for	ADP
admet-2415	154	13	the	the	DET
admet-2415	154	14	nanocrystal	nanocrystal	ADJ
admet-2415	154	15	formulation	formulation	NOUN
admet-2415	154	16	increased	increase	VERB
admet-2415	154	17	as	as	ADP
admet-2415	154	18	such	such	ADJ
admet-2415	154	19	:	:	PUNCT
admet-2415	154	20	liver	liver	NOUN
admet-2415	154	21	by	by	ADP
admet-2415	154	22	5	5	NUM
admet-2415	154	23	-	-	NOUN
admet-2415	154	24	fold	fold	ADJ
admet-2415	154	25	,	,	PUNCT
admet-2415	154	26	spleen	spleen	NOUN
admet-2415	154	27	by	by	ADP
admet-2415	154	28	8	8	NUM
admet-2415	154	29	-	-	NOUN
admet-2415	154	30	fold	fold	ADJ
admet-2415	154	31	,	,	PUNCT
admet-2415	154	32	and	and	CCONJ
admet-2415	154	33	lung	lung	NOUN
admet-2415	154	34	by	by	ADP
admet-2415	154	35	2	2	NUM
admet-2415	154	36	-	-	NOUN
admet-2415	154	37	fold	fold	ADJ
admet-2415	154	38	.	.	PUNCT
admet-2415	155	1	this	this	PRON
admet-2415	155	2	is	be	AUX
admet-2415	155	3	likely	likely	ADJ
admet-2415	155	4	due	due	ADP
admet-2415	155	5	to	to	ADP
admet-2415	155	6	the	the	DET
admet-2415	155	7	mps	mps	PROPN
admet-2415	155	8	sequestration	sequestration	NOUN
admet-2415	155	9	,	,	PUNCT
admet-2415	155	10	with	with	ADP
admet-2415	155	11	the	the	DET
admet-2415	155	12	liver	liver	NOUN
admet-2415	155	13	being	be	AUX
admet-2415	155	14	the	the	DET
admet-2415	155	15	major	major	ADJ
admet-2415	155	16	organ	organ	NOUN
admet-2415	155	17	for	for	ADP
admet-2415	155	18	removing	remove	VERB
admet-2415	155	19	nanoparticles	nanoparticle	NOUN
admet-2415	155	20	from	from	ADP
admet-2415	155	21	blood	blood	NOUN
admet-2415	155	22	circulation	circulation	NOUN
admet-2415	155	23	.	.	PUNCT
admet-2415	156	1	for	for	ADP
admet-2415	156	2	taxol	taxol	PROPN
admet-2415	156	3	,	,	PUNCT
admet-2415	156	4	the	the	DET
admet-2415	156	5	kidney	kidney	NOUN
admet-2415	156	6	had	have	VERB
admet-2415	156	7	the	the	DET
admet-2415	156	8	second	second	ADJ
admet-2415	156	9	highest	high	ADJ
admet-2415	156	10	partition	partition	NOUN
admet-2415	156	11	coefficient	coefficient	NOUN
admet-2415	156	12	of	of	ADP
admet-2415	156	13	0.75	0.75	NUM
admet-2415	156	14	(	(	PUNCT
admet-2415	156	15	unitless	unitless	NOUN
admet-2415	156	16	)	)	PUNCT
admet-2415	156	17	after	after	ADP
admet-2415	156	18	the	the	DET
admet-2415	156	19	liver	liver	NOUN
admet-2415	156	20	;	;	PUNCT
admet-2415	156	21	the	the	DET
admet-2415	156	22	number	number	NOUN
admet-2415	156	23	decreased	decrease	VERB
admet-2415	156	24	to	to	ADP
admet-2415	156	25	0.41	0.41	NUM
admet-2415	156	26	for	for	ADP
admet-2415	156	27	the	the	DET
admet-2415	156	28	nanocrystal	nanocrystal	ADJ
admet-2415	156	29	formulation	formulation	NOUN
admet-2415	156	30	.	.	PUNCT
admet-2415	157	1	with	with	ADP
admet-2415	157	2	the	the	DET
admet-2415	157	3	increased	increase	VERB
admet-2415	157	4	liver	liver	NOUN
admet-2415	157	5	uptake	uptake	NOUN
admet-2415	157	6	and	and	CCONJ
admet-2415	157	7	decreased	decrease	VERB
admet-2415	157	8	renal	renal	ADJ
admet-2415	157	9	clearance	clearance	NOUN
admet-2415	157	10	,	,	PUNCT
admet-2415	157	11	the	the	DET
admet-2415	157	12	liver	liver	NOUN
admet-2415	157	13	could	could	AUX
admet-2415	157	14	be	be	AUX
admet-2415	157	15	considered	consider	VERB
admet-2415	157	16	a	a	DET
admet-2415	157	17	major	major	ADJ
admet-2415	157	18	depot	depot	NOUN
admet-2415	157	19	site	site	NOUN
admet-2415	157	20	for	for	ADP
admet-2415	157	21	drug	drug	NOUN
admet-2415	157	22	nanocrystals	nanocrystal	NOUN
admet-2415	157	23	.	.	PUNCT
admet-2415	158	1	moreover	moreover	ADV
admet-2415	158	2	,	,	PUNCT
admet-2415	158	3	surface	surface	NOUN
admet-2415	158	4	treatment	treatment	NOUN
admet-2415	158	5	by	by	ADP
admet-2415	158	6	f68	f68	NOUN
admet-2415	158	7	reduced	reduce	VERB
admet-2415	158	8	the	the	DET
admet-2415	158	9	liver	liver	NOUN
admet-2415	158	10	partition	partition	NOUN
admet-2415	158	11	coefficient	coefficient	NOUN
admet-2415	158	12	from	from	ADP
admet-2415	158	13	10.99	10.99	NUM
admet-2415	158	14	to	to	ADP
admet-2415	158	15	6.92	6.92	NUM
admet-2415	158	16	,	,	PUNCT
admet-2415	158	17	which	which	PRON
admet-2415	158	18	was	be	AUX
admet-2415	158	19	still	still	ADV
admet-2415	158	20	3.3	3.3	NUM
admet-2415	158	21	folds	fold	NOUN
admet-2415	158	22	greater	great	ADJ
admet-2415	158	23	than	than	ADP
admet-2415	158	24	taxol	taxol	NOUN
admet-2415	158	25	's	's	PART
admet-2415	158	26	.	.	PUNCT
admet-2415	159	1	f68	f68	PROPN
admet-2415	159	2	coating	coating	NOUN
admet-2415	159	3	minimized	minimize	VERB
admet-2415	159	4	the	the	DET
admet-2415	159	5	liver	liver	NOUN
admet-2415	159	6	uptake	uptake	NOUN
admet-2415	159	7	and	and	CCONJ
admet-2415	159	8	,	,	PUNCT
admet-2415	159	9	compared	compare	VERB
admet-2415	159	10	with	with	ADP
admet-2415	159	11	the	the	DET
admet-2415	159	12	other	other	ADJ
admet-2415	159	13	two	two	NUM
admet-2415	159	14	formulations	formulation	NOUN
admet-2415	159	15	,	,	PUNCT
admet-2415	159	16	significantly	significantly	ADV
admet-2415	159	17	lowered	lower	VERB
admet-2415	159	18	clearance	clearance	NOUN
admet-2415	159	19	,	,	PUNCT
admet-2415	159	20	suggesting	suggest	VERB
admet-2415	159	21	prolonged	prolonged	ADJ
admet-2415	159	22	blood	blood	NOUN
admet-2415	159	23	circulation	circulation	NOUN
admet-2415	159	24	.	.	PUNCT
admet-2415	160	1	the	the	DET
admet-2415	160	2	surface	surface	NOUN
admet-2415	160	3	treatment	treatment	NOUN
admet-2415	160	4	also	also	ADV
admet-2415	160	5	eased	ease	VERB
admet-2415	160	6	the	the	DET
admet-2415	160	7	drug	drug	NOUN
admet-2415	160	8	tissue	tissue	NOUN
admet-2415	160	9	affinity	affinity	NOUN
admet-2415	160	10	in	in	ADP
admet-2415	160	11	the	the	DET
admet-2415	160	12	spleen	spleen	NOUN
admet-2415	160	13	,	,	PUNCT
admet-2415	160	14	heart	heart	NOUN
admet-2415	160	15	,	,	PUNCT
admet-2415	160	16	kidney	kidney	NOUN
admet-2415	160	17	,	,	PUNCT
admet-2415	160	18	and	and	CCONJ
admet-2415	160	19	lung	lung	NOUN
admet-2415	160	20	,	,	PUNCT
admet-2415	160	21	helping	help	VERB
admet-2415	160	22	to	to	PART
admet-2415	160	23	lighten	lighten	VERB
admet-2415	160	24	toxic	toxic	ADJ
admet-2415	160	25	effects	effect	NOUN
admet-2415	160	26	in	in	ADP
admet-2415	160	27	these	these	DET
admet-2415	160	28	organs	organ	NOUN
admet-2415	160	29	and	and	CCONJ
admet-2415	160	30	enhancing	enhance	VERB
admet-2415	160	31	drug	drug	NOUN
admet-2415	160	32	circulation	circulation	NOUN
admet-2415	160	33	.	.	PUNCT
admet-2415	161	1	in	in	ADP
admet-2415	161	2	the	the	DET
admet-2415	161	3	tumor	tumor	NOUN
admet-2415	161	4	,	,	PUNCT
admet-2415	161	5	the	the	DET
admet-2415	161	6	partition	partition	NOUN
admet-2415	161	7	coefficients	coefficient	NOUN
admet-2415	161	8	of	of	ADP
admet-2415	161	9	taxol	taxol	NOUN
admet-2415	161	10	,	,	PUNCT
admet-2415	161	11	ptx	ptx	PROPN
admet-2415	161	12	-	-	PUNCT
admet-2415	161	13	nc	nc	PROPN
admet-2415	161	14	,	,	PUNCT
admet-2415	161	15	and	and	CCONJ
admet-2415	161	16	f68	f68	ADJ
admet-2415	161	17	-	-	PUNCT
admet-2415	161	18	ptx	ptx	NOUN
admet-2415	161	19	-	-	PUNCT
admet-2415	161	20	nc	nc	NOUN
admet-2415	161	21	are	be	AUX
admet-2415	161	22	0.27	0.27	NUM
admet-2415	161	23	,	,	PUNCT
admet-2415	161	24	0.28	0.28	NUM
admet-2415	161	25	,	,	PUNCT
admet-2415	161	26	and	and	CCONJ
admet-2415	161	27	0.65	0.65	NUM
admet-2415	161	28	,	,	PUNCT
admet-2415	161	29	respectively	respectively	ADV
admet-2415	161	30	.	.	PUNCT
admet-2415	162	1	the	the	DET
admet-2415	162	2	surface	surface	NOUN
admet-2415	162	3	treatment	treatment	NOUN
admet-2415	162	4	increased	increase	VERB
admet-2415	162	5	the	the	DET
admet-2415	162	6	tumor	tumor	NOUN
admet-2415	162	7	partition	partition	NOUN
admet-2415	162	8	(	(	PUNCT
admet-2415	162	9	by	by	ADP
admet-2415	162	10	2.5	2.5	NUM
admet-2415	162	11	folds	fold	NOUN
admet-2415	162	12	)	)	PUNCT
admet-2415	162	13	,	,	PUNCT
admet-2415	162	14	supporting	support	VERB
admet-2415	162	15	our	our	PRON
admet-2415	162	16	experimental	experimental	ADJ
admet-2415	162	17	observation	observation	NOUN
admet-2415	162	18	in	in	ADP
admet-2415	162	19	animals	animal	NOUN
admet-2415	162	20	[	[	X
admet-2415	162	21	10,11	10,11	NOUN
admet-2415	162	22	]	]	PUNCT
admet-2415	162	23	.	.	PUNCT
admet-2415	163	1	while	while	SCONJ
admet-2415	163	2	keeping	keep	VERB
admet-2415	163	3	the	the	DET
admet-2415	163	4	partition	partition	NOUN
admet-2415	163	5	coefficients	coefficient	NOUN
admet-2415	163	6	and	and	CCONJ
admet-2415	163	7	parameters	parameter	NOUN
admet-2415	163	8	fixed	fix	VERB
admet-2415	163	9	,	,	PUNCT
admet-2415	163	10	we	we	PRON
admet-2415	163	11	ran	run	VERB
admet-2415	163	12	pk	pk	NOUN
admet-2415	163	13	simulations	simulation	NOUN
admet-2415	163	14	with	with	ADP
admet-2415	163	15	several	several	ADJ
admet-2415	163	16	different	different	ADJ
admet-2415	163	17	values	value	NOUN
admet-2415	163	18	of	of	ADP
admet-2415	163	19	the	the	DET
admet-2415	163	20	tumor	tumor	NOUN
admet-2415	163	21	partition	partition	NOUN
admet-2415	163	22	coefficient	coefficient	NOUN
admet-2415	163	23	.	.	PUNCT
admet-2415	164	1	table	table	NOUN
admet-2415	164	2	4	4	NUM
admet-2415	164	3	shows	show	VERB
admet-2415	164	4	the	the	DET
admet-2415	164	5	simulation	simulation	NOUN
admet-2415	164	6	results	result	VERB
admet-2415	164	7	with	with	ADP
admet-2415	164	8	the	the	DET
admet-2415	164	9	partition	partition	NOUN
admet-2415	164	10	coefficient	coefficient	NOUN
admet-2415	164	11	ranging	range	VERB
admet-2415	164	12	from	from	ADP
admet-2415	164	13	the	the	DET
admet-2415	164	14	smallest	small	ADJ
admet-2415	164	15	value	value	NOUN
admet-2415	164	16	of	of	ADP
admet-2415	164	17	0.27	0.27	NUM
admet-2415	164	18	,	,	PUNCT
admet-2415	164	19	which	which	PRON
admet-2415	164	20	was	be	AUX
admet-2415	164	21	of	of	ADP
admet-2415	164	22	taxol	taxol	NOUN
admet-2415	164	23	,	,	PUNCT
admet-2415	164	24	to	to	ADP
admet-2415	164	25	a	a	DET
admet-2415	164	26	more	more	ADV
admet-2415	164	27	significant	significant	ADJ
admet-2415	164	28	,	,	PUNCT
admet-2415	164	29	hypothetical	hypothetical	ADJ
admet-2415	164	30	number	number	NOUN
admet-2415	164	31	of	of	ADP
admet-2415	164	32	0.87	0.87	NUM
admet-2415	164	33	for	for	ADP
admet-2415	164	34	all	all	DET
admet-2415	164	35	three	three	NUM
admet-2415	164	36	formulations	formulation	NOUN
admet-2415	164	37	.	.	PUNCT
admet-2415	165	1	both	both	DET
admet-2415	165	2	maximal	maximal	ADJ
admet-2415	165	3	concentration	concentration	NOUN
admet-2415	165	4	(	(	PUNCT
admet-2415	165	5	cmax	cmax	NOUN
admet-2415	165	6	)	)	PUNCT
admet-2415	165	7	and	and	CCONJ
admet-2415	165	8	area	area	NOUN
admet-2415	165	9	under	under	ADP
admet-2415	165	10	curve	curve	NOUN
admet-2415	165	11	(	(	PUNCT
admet-2415	165	12	auc	auc	NOUN
admet-2415	165	13	)	)	PUNCT
admet-2415	165	14	values	value	NOUN
admet-2415	165	15	in	in	ADP
admet-2415	165	16	tumor	tumor	NOUN
admet-2415	165	17	became	become	VERB
admet-2415	165	18	larger	large	ADJ
admet-2415	165	19	as	as	SCONJ
admet-2415	165	20	the	the	DET
admet-2415	165	21	tumor	tumor	NOUN
admet-2415	165	22	partition	partition	NOUN
admet-2415	165	23	coefficient	coefficient	NOUN
admet-2415	165	24	(	(	PUNCT
admet-2415	165	25	kpartittion	kpartittion	NOUN
admet-2415	165	26	)	)	PUNCT
admet-2415	165	27	increased	increase	VERB
admet-2415	165	28	.	.	PUNCT
admet-2415	166	1	the	the	DET
admet-2415	166	2	cmax	cmax	NOUN
admet-2415	166	3	increased	increase	VERB
admet-2415	166	4	about	about	ADV
admet-2415	166	5	two	two	NUM
admet-2415	166	6	times	time	NOUN
admet-2415	166	7	and	and	CCONJ
admet-2415	166	8	auc	auc	VERB
admet-2415	166	9	about	about	ADV
admet-2415	166	10	three	three	NUM
admet-2415	166	11	to	to	PART
admet-2415	166	12	four	four	NUM
admet-2415	166	13	times	time	NOUN
admet-2415	166	14	due	due	ADP
admet-2415	166	15	to	to	ADP
admet-2415	166	16	the	the	DET
admet-2415	166	17	increase	increase	NOUN
admet-2415	166	18	in	in	ADP
admet-2415	166	19	tumor	tumor	NOUN
admet-2415	166	20	partition	partition	NOUN
admet-2415	166	21	.	.	PUNCT
admet-2415	167	1	thus	thus	ADV
admet-2415	167	2	,	,	PUNCT
admet-2415	167	3	given	give	VERB
admet-2415	167	4	the	the	DET
admet-2415	167	5	same	same	ADJ
admet-2415	167	6	dose	dose	NOUN
admet-2415	167	7	,	,	PUNCT
admet-2415	167	8	the	the	PRON
admet-2415	167	9	higher	high	ADJ
admet-2415	167	10	the	the	DET
admet-2415	167	11	tumor	tumor	NOUN
admet-2415	167	12	partition	partition	NOUN
admet-2415	167	13	coefficient	coefficient	NOUN
admet-2415	167	14	,	,	PUNCT
admet-2415	167	15	the	the	DET
admet-2415	167	16	more	more	ADJ
admet-2415	167	17	drug	drug	NOUN
admet-2415	167	18	accumulation	accumulation	NOUN
admet-2415	167	19	in	in	ADP
admet-2415	167	20	the	the	DET
admet-2415	167	21	organ	organ	NOUN
admet-2415	167	22	,	,	PUNCT
admet-2415	167	23	resulting	result	VERB
admet-2415	167	24	in	in	ADP
admet-2415	167	25	better	well	ADJ
admet-2415	167	26	treatment	treatment	NOUN
admet-2415	167	27	efficacy	efficacy	NOUN
admet-2415	167	28	.	.	PUNCT
admet-2415	168	1	f68	f68	PROPN
admet-2415	168	2	-	-	PUNCT
admet-2415	168	3	ptx	ptx	NOUN
admet-2415	168	4	-	-	PUNCT
admet-2415	168	5	nc	nc	PROPN
admet-2415	168	6	showed	show	VERB
admet-2415	168	7	the	the	DET
admet-2415	168	8	highest	high	ADJ
admet-2415	168	9	pk	pk	NOUN
admet-2415	168	10	performance	performance	NOUN
admet-2415	168	11	in	in	ADP
admet-2415	168	12	the	the	DET
admet-2415	168	13	tumor	tumor	NOUN
admet-2415	168	14	compartment	compartment	NOUN
admet-2415	168	15	because	because	SCONJ
admet-2415	168	16	of	of	ADP
admet-2415	168	17	decreased	decrease	VERB
admet-2415	168	18	tissue	tissue	NOUN
admet-2415	168	19	affinities	affinity	NOUN
admet-2415	168	20	with	with	ADP
admet-2415	168	21	the	the	DET
admet-2415	168	22	surface	surface	NOUN
admet-2415	168	23	treatment	treatment	NOUN
admet-2415	168	24	among	among	ADP
admet-2415	168	25	the	the	DET
admet-2415	168	26	three	three	NUM
admet-2415	168	27	delivery	delivery	NOUN
admet-2415	168	28	systems	system	NOUN
admet-2415	168	29	.	.	PUNCT
admet-2415	169	1	admet	admet	PROPN
admet-2415	169	2	&	&	CCONJ
admet-2415	169	3	dmpk	dmpk	PROPN
admet-2415	169	4	12(5	12(5	NUM
admet-2415	169	5	)	)	PUNCT
admet-2415	169	6	(	(	PUNCT
admet-2415	169	7	2024	2024	NUM
admet-2415	169	8	)	)	PUNCT
admet-2415	169	9	705	705	NUM
admet-2415	169	10	-	-	SYM
admet-2415	169	11	719	719	NUM
admet-2415	169	12	drug	drug	NOUN
admet-2415	169	13	delivery	delivery	NOUN
admet-2415	169	14	to	to	ADP
admet-2415	169	15	tumor	tumor	NOUN
admet-2415	169	16	by	by	ADP
admet-2415	169	17	nanoparticles	nanoparticle	NOUN
admet-2415	169	18	doi	doi	NOUN
admet-2415	169	19	:	:	PUNCT
admet-2415	169	20	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	169	21	711	711	NUM
admet-2415	169	22	time	time	NOUN
admet-2415	169	23	,	,	PUNCT
admet-2415	169	24	h	h	NOUN
admet-2415	169	25	figure	figure	NOUN
admet-2415	169	26	2	2	NUM
admet-2415	169	27	.	.	PUNCT
admet-2415	169	28	concentration	concentration	NOUN
admet-2415	169	29	of	of	ADP
admet-2415	169	30	three	three	NUM
admet-2415	169	31	ptx	ptx	NOUN
admet-2415	169	32	formulations	formulation	NOUN
admet-2415	169	33	following	follow	VERB
admet-2415	169	34	20	20	NUM
admet-2415	169	35	mg	mg	NUM
admet-2415	169	36	/	/	SYM
admet-2415	169	37	kg	kg	NOUN
admet-2415	169	38	iv	iv	NUM
admet-2415	169	39	injection	injection	NOUN
admet-2415	169	40	with	with	ADP
admet-2415	169	41	respectively	respectively	ADV
admet-2415	169	42	fitted	fit	VERB
admet-2415	169	43	lines	line	NOUN
admet-2415	169	44	(	(	PUNCT
admet-2415	169	45	red	red	ADJ
admet-2415	169	46	)	)	PUNCT
admet-2415	169	47	.	.	PUNCT
admet-2415	170	1	table	table	NOUN
admet-2415	170	2	4	4	NUM
admet-2415	170	3	.	.	PUNCT
admet-2415	171	1	simulation	simulation	NOUN
admet-2415	171	2	results	result	VERB
admet-2415	171	3	with	with	ADP
admet-2415	171	4	different	different	ADJ
admet-2415	171	5	tumor	tumor	NOUN
admet-2415	171	6	partition	partition	NOUN
admet-2415	171	7	coefficients	coefficient	NOUN
admet-2415	171	8	.	.	PUNCT
admet-2415	172	1	tumor	tumor	NOUN
admet-2415	172	2	kpartittion	kpartittion	PROPN
admet-2415	172	3	auc	auc	PROPN
admet-2415	172	4	taxol	taxol	PROPN
admet-2415	172	5	cmax	cmax	NOUN
admet-2415	172	6	taxol	taxol	PROPN
admet-2415	172	7	/	/	SYM
admet-2415	172	8	g	g	PROPN
admet-2415	172	9	ml	ml	AUX
admet-2415	172	10	auc	auc	VERB
admet-2415	172	11	ptx	ptx	VERB
admet-2415	172	12	-	-	PUNCT
admet-2415	172	13	nc	nc	PROPN
admet-2415	172	14	cmax	cmax	PROPN
admet-2415	172	15	ptx	ptx	PROPN
admet-2415	172	16	-	-	PROPN
admet-2415	172	17	nc	nc	PROPN
admet-2415	172	18	/	/	SYM
admet-2415	172	19	g	g	PROPN
admet-2415	172	20	ml	ml	AUX
admet-2415	172	21	auc	auc	VERB
admet-2415	172	22	f68	f68	ADJ
admet-2415	172	23	-	-	PUNCT
admet-2415	172	24	ptx	ptx	ADJ
admet-2415	172	25	cmax	cmax	NOUN
admet-2415	172	26	f68	f68	VERB
admet-2415	172	27	-	-	PUNCT
admet-2415	172	28	ptx	ptx	NOUN
admet-2415	172	29	/	/	SYM
admet-2415	172	30	g	g	PROPN
admet-2415	172	31	ml	ml	NOUN
admet-2415	172	32	0.28	0.28	NUM
admet-2415	172	33	8.75	8.75	NUM
admet-2415	172	34	2.78	2.78	NUM
admet-2415	172	35	5.31	5.31	NUM
admet-2415	172	36	1.91	1.91	NUM
admet-2415	172	37	55.16	55.16	NUM
admet-2415	172	38	2.77	2.77	NUM
admet-2415	172	39	0.43	0.43	NUM
admet-2415	172	40	13.40	13.40	NUM
admet-2415	172	41	3.74	3.74	NUM
admet-2415	172	42	8.13	8.13	NUM
admet-2415	172	43	2.54	2.54	NUM
admet-2415	172	44	83.23	83.23	NUM
admet-2415	172	45	4.14	4.14	NUM
admet-2415	172	46	0.57	0.57	NUM
admet-2415	172	47	18.048	18.048	NUM
admet-2415	172	48	4.53	4.53	NUM
admet-2415	172	49	10.95	10.95	NUM
admet-2415	172	50	3.057	3.057	NUM
admet-2415	172	51	110.56	110.56	NUM
admet-2415	172	52	5.47	5.47	NUM
admet-2415	172	53	0.72	0.72	NUM
admet-2415	172	54	22.70	22.70	NUM
admet-2415	172	55	5.20	5.20	NUM
admet-2415	172	56	13.78	13.78	NUM
admet-2415	172	57	3.49	3.49	NUM
admet-2415	172	58	137.092	137.092	NUM
admet-2415	172	59	6.74	6.74	NUM
admet-2415	172	60	0.87	0.87	NUM
admet-2415	172	61	27.35	27.35	NUM
admet-2415	172	62	5.79	5.79	NUM
admet-2415	172	63	16.60	16.60	NUM
admet-2415	172	64	3.87	3.87	NUM
admet-2415	172	65	162.84	162.84	NUM
admet-2415	172	66	7.96	7.96	NUM
admet-2415	172	67	pd	pd	NOUN
admet-2415	172	68	modeling	model	VERB
admet-2415	172	69	experimental	experimental	ADJ
admet-2415	172	70	measurements	measurement	NOUN
admet-2415	172	71	of	of	ADP
admet-2415	172	72	tumor	tumor	NOUN
admet-2415	172	73	growth	growth	NOUN
admet-2415	172	74	from	from	ADP
admet-2415	172	75	our	our	PRON
admet-2415	172	76	earlier	early	ADJ
admet-2415	172	77	studies	study	NOUN
admet-2415	172	78	were	be	AUX
admet-2415	172	79	used	use	VERB
admet-2415	172	80	to	to	PART
admet-2415	172	81	establish	establish	VERB
admet-2415	172	82	the	the	DET
admet-2415	172	83	pd	pd	PROPN
admet-2415	172	84	model	model	NOUN
admet-2415	172	85	.	.	PUNCT
admet-2415	173	1	values	value	NOUN
admet-2415	173	2	of	of	ADP
admet-2415	173	3	the	the	DET
admet-2415	173	4	control	control	NOUN
admet-2415	173	5	treatment	treatment	NOUN
admet-2415	173	6	group	group	NOUN
admet-2415	173	7	were	be	AUX
admet-2415	173	8	first	first	ADV
admet-2415	173	9	fitted	fit	VERB
admet-2415	173	10	in	in	ADP
admet-2415	173	11	order	order	NOUN
admet-2415	173	12	to	to	PART
admet-2415	173	13	obtain	obtain	VERB
admet-2415	173	14	the	the	DET
admet-2415	173	15	growth	growth	NOUN
admet-2415	173	16	rate	rate	NOUN
admet-2415	173	17	parameters	parameter	NOUN
admet-2415	173	18	of	of	ADP
admet-2415	173	19	the	the	DET
admet-2415	173	20	tumor	tumor	NOUN
admet-2415	173	21	(	(	PUNCT
admet-2415	173	22	k0	k0	PROPN
admet-2415	173	23	and	and	CCONJ
admet-2415	173	24	k1	k1	NOUN
admet-2415	173	25	in	in	ADP
admet-2415	173	26	eq	eq	ADP
admet-2415	173	27	.	.	PROPN
admet-2415	173	28	11	11	NUM
admet-2415	173	29	)	)	PUNCT
admet-2415	173	30	.	.	PUNCT
admet-2415	174	1	figure	figure	NOUN
admet-2415	174	2	3	3	NUM
admet-2415	174	3	shows	show	VERB
admet-2415	174	4	the	the	DET
admet-2415	174	5	experimental	experimental	ADJ
admet-2415	174	6	data	datum	NOUN
admet-2415	174	7	and	and	CCONJ
admet-2415	174	8	predicted	predict	VERB
admet-2415	174	9	trends	trend	NOUN
admet-2415	174	10	in	in	ADP
admet-2415	174	11	tumor	tumor	NOUN
admet-2415	174	12	growth	growth	NOUN
admet-2415	174	13	d	d	PROPN
admet-2415	174	14	ru	ru	PROPN
admet-2415	174	15	g	g	PROPN
admet-2415	174	16	co	co	PROPN
admet-2415	174	17	n	n	PROPN
admet-2415	174	18	ce	ce	PROPN
admet-2415	174	19	n	n	CCONJ
admet-2415	174	20	tr	tr	VERB
admet-2415	174	21	at	at	ADP
admet-2415	174	22	io	io	X
admet-2415	174	23	n	n	X
admet-2415	174	24	,	,	PUNCT
admet-2415	174	25			NOUN
admet-2415	174	26	g/	g/	NOUN
admet-2415	174	27	m	m	NOUN
admet-2415	174	28	l	l	NOUN
admet-2415	174	29	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	175	1	s.	s.	PROPN
admet-2415	175	2	lu	lu	PROPN
admet-2415	175	3	et	et	PROPN
admet-2415	175	4	al	al	PROPN
admet-2415	175	5	.	.	PROPN
admet-2415	175	6	admet	admet	PROPN
admet-2415	175	7	&	&	CCONJ
admet-2415	175	8	dmpk	dmpk	PROPN
admet-2415	175	9	12(5	12(5	NUM
admet-2415	175	10	)	)	PUNCT
admet-2415	175	11	(	(	PUNCT
admet-2415	175	12	2024	2024	NUM
admet-2415	175	13	)	)	PUNCT
admet-2415	175	14	705	705	NUM
admet-2415	175	15	-	-	SYM
admet-2415	175	16	719	719	NUM
admet-2415	175	17	712	712	NUM
admet-2415	175	18	up	up	ADP
admet-2415	175	19	to	to	PART
admet-2415	175	20	23	23	NUM
admet-2415	175	21	days	day	NOUN
admet-2415	175	22	of	of	ADP
admet-2415	175	23	individual	individual	ADJ
admet-2415	175	24	mice	mouse	NOUN
admet-2415	175	25	injected	inject	VERB
admet-2415	175	26	with	with	ADP
admet-2415	175	27	saline	saline	ADJ
admet-2415	175	28	solution	solution	NOUN
admet-2415	175	29	.	.	PUNCT
admet-2415	176	1	the	the	DET
admet-2415	176	2	tumor	tumor	NOUN
admet-2415	176	3	growth	growth	NOUN
admet-2415	176	4	model	model	NOUN
admet-2415	176	5	was	be	AUX
admet-2415	176	6	able	able	ADJ
admet-2415	176	7	to	to	PART
admet-2415	176	8	describe	describe	VERB
admet-2415	176	9	the	the	DET
admet-2415	176	10	experimental	experimental	ADJ
admet-2415	176	11	data	datum	NOUN
admet-2415	176	12	well	well	ADV
admet-2415	176	13	.	.	PUNCT
admet-2415	177	1	the	the	DET
admet-2415	177	2	average	average	ADJ
admet-2415	177	3	tumor	tumor	NOUN
admet-2415	177	4	linear	linear	ADJ
admet-2415	177	5	growth	growth	NOUN
admet-2415	177	6	factor	factor	NOUN
admet-2415	177	7	k1	k1	NOUN
admet-2415	177	8	and	and	CCONJ
admet-2415	177	9	exponential	exponential	ADJ
admet-2415	177	10	growth	growth	NOUN
admet-2415	177	11	factor	factor	NOUN
admet-2415	177	12	k2	k2	PROPN
admet-2415	177	13	were	be	AUX
admet-2415	177	14	0.17	0.17	NUM
admet-2415	177	15	(	(	PUNCT
admet-2415	177	16	±	±	NOUN
admet-2415	177	17	0.11	0.11	NUM
admet-2415	177	18	)	)	PUNCT
admet-2415	177	19	and	and	CCONJ
admet-2415	177	20	0.51	0.51	NUM
admet-2415	177	21	(	(	PUNCT
admet-2415	177	22	±	±	NOUN
admet-2415	177	23	0.56	0.56	NUM
admet-2415	177	24	)	)	PUNCT
admet-2415	177	25	grams	gram	NOUN
admet-2415	177	26	per	per	ADP
admet-2415	177	27	day	day	NOUN
admet-2415	177	28	,	,	PUNCT
admet-2415	177	29	respectively	respectively	ADV
admet-2415	177	30	.	.	PUNCT
admet-2415	178	1	the	the	DET
admet-2415	178	2	growth	growth	NOUN
admet-2415	178	3	factors	factor	NOUN
admet-2415	178	4	were	be	AUX
admet-2415	178	5	then	then	ADV
admet-2415	178	6	applied	apply	VERB
admet-2415	178	7	to	to	PART
admet-2415	178	8	analyze	analyze	VERB
admet-2415	178	9	kd	kd	PROPN
admet-2415	178	10	and	and	CCONJ
admet-2415	178	11			NOUN
admet-2415	178	12	of	of	ADP
admet-2415	178	13	the	the	DET
admet-2415	178	14	drug	drug	NOUN
admet-2415	178	15	treatment	treatment	NOUN
admet-2415	178	16	by	by	ADP
admet-2415	178	17	taxol	taxol	PROPN
admet-2415	178	18	and	and	CCONJ
admet-2415	178	19	ptx	ptx	PROPN
admet-2415	178	20	ncs	ncs	PROPN
admet-2415	178	21	.	.	PUNCT
admet-2415	179	1	time	time	NOUN
admet-2415	179	2	,	,	PUNCT
admet-2415	179	3	day	day	NOUN
admet-2415	179	4	figure	figure	NOUN
admet-2415	179	5	3	3	NUM
admet-2415	179	6	.	.	PUNCT
admet-2415	179	7	tumor	tumor	NOUN
admet-2415	179	8	growth	growth	NOUN
admet-2415	179	9	of	of	ADP
admet-2415	179	10	12	12	NUM
admet-2415	179	11	individual	individual	ADJ
admet-2415	179	12	mice	mouse	NOUN
admet-2415	179	13	treated	treat	VERB
admet-2415	179	14	with	with	ADP
admet-2415	179	15	saline	saline	NOUN
admet-2415	179	16	(	(	PUNCT
admet-2415	179	17	control	control	NOUN
admet-2415	179	18	group	group	NOUN
admet-2415	179	19	)	)	PUNCT
admet-2415	179	20	the	the	DET
admet-2415	179	21	tumor	tumor	NOUN
admet-2415	179	22	treatment	treatment	NOUN
admet-2415	179	23	parameters	parameter	NOUN
admet-2415	179	24	were	be	AUX
admet-2415	179	25	obtained	obtain	VERB
admet-2415	179	26	by	by	ADP
admet-2415	179	27	fitting	fit	VERB
admet-2415	179	28	the	the	DET
admet-2415	179	29	pd	pd	PROPN
admet-2415	179	30	model	model	NOUN
admet-2415	179	31	against	against	ADP
admet-2415	179	32	the	the	DET
admet-2415	179	33	experimental	experimental	ADJ
admet-2415	179	34	data	datum	NOUN
admet-2415	179	35	with	with	ADP
admet-2415	179	36	the	the	DET
admet-2415	179	37	availability	availability	NOUN
admet-2415	179	38	of	of	ADP
admet-2415	179	39	k1	k1	NOUN
admet-2415	179	40	and	and	CCONJ
admet-2415	179	41	k2	k2	NOUN
admet-2415	179	42	.	.	PUNCT
admet-2415	180	1	the	the	DET
admet-2415	180	2	transit	transit	NOUN
admet-2415	180	3	parameter	parameter	NOUN
admet-2415	180	4	𝜏	𝜏	NOUN
admet-2415	180	5	that	that	PRON
admet-2415	180	6	characterizes	characterize	VERB
admet-2415	180	7	the	the	DET
admet-2415	180	8	kinetics	kinetic	NOUN
admet-2415	180	9	of	of	ADP
admet-2415	180	10	cell	cell	NOUN
admet-2415	180	11	damage	damage	NOUN
admet-2415	180	12	are	be	AUX
admet-2415	180	13	0.93	0.93	NUM
admet-2415	180	14	,	,	PUNCT
admet-2415	180	15	0.96	0.96	NUM
admet-2415	180	16	,	,	PUNCT
admet-2415	180	17	and	and	CCONJ
admet-2415	180	18	0.95	0.95	NUM
admet-2415	180	19	day-1	day-1	NUM
admet-2415	180	20	for	for	ADP
admet-2415	180	21	taxol	taxol	NOUN
admet-2415	180	22	,	,	PUNCT
admet-2415	180	23	ptx	ptx	PROPN
admet-2415	180	24	-	-	PUNCT
admet-2415	180	25	nc	nc	PROPN
admet-2415	180	26	,	,	PUNCT
admet-2415	180	27	and	and	CCONJ
admet-2415	180	28	f68	f68	ADJ
admet-2415	180	29	-	-	PUNCT
admet-2415	180	30	ptx	ptx	NOUN
admet-2415	180	31	-	-	PUNCT
admet-2415	180	32	nc	nc	NOUN
admet-2415	180	33	,	,	PUNCT
admet-2415	180	34	respectively	respectively	ADV
admet-2415	180	35	.	.	PUNCT
admet-2415	181	1	the	the	DET
admet-2415	181	2	parameter	parameter	NOUN
admet-2415	181	3	to	to	PART
admet-2415	181	4	quantify	quantify	VERB
admet-2415	181	5	drug	drug	NOUN
admet-2415	181	6	efficacy	efficacy	NOUN
admet-2415	181	7	,	,	PUNCT
admet-2415	181	8	kd	kd	PROPN
admet-2415	181	9	,	,	PUNCT
admet-2415	181	10	is	be	AUX
admet-2415	181	11	0.0039	0.0039	NUM
admet-2415	181	12	,	,	PUNCT
admet-2415	181	13	0.0037	0.0037	NUM
admet-2415	181	14	,	,	PUNCT
admet-2415	181	15	and	and	CCONJ
admet-2415	181	16	0.0038	0.0038	NUM
admet-2415	181	17	ml	ml	NOUN
admet-2415	181	18	ng-1	ng-1	PUNCT
admet-2415	181	19	day-1	day-1	NUM
admet-2415	181	20	of	of	ADP
admet-2415	181	21	each	each	DET
admet-2415	181	22	respective	respective	ADJ
admet-2415	181	23	treatment	treatment	NOUN
admet-2415	181	24	.	.	PUNCT
admet-2415	182	1	the	the	DET
admet-2415	182	2	minor	minor	ADJ
admet-2415	182	3	differences	difference	NOUN
admet-2415	182	4	in	in	ADP
admet-2415	182	5	the	the	DET
admet-2415	182	6	parameters	parameter	NOUN
admet-2415	182	7	among	among	ADP
admet-2415	182	8	the	the	DET
admet-2415	182	9	drug	drug	NOUN
admet-2415	182	10	delivery	delivery	NOUN
admet-2415	182	11	systems	system	NOUN
admet-2415	182	12	indicate	indicate	VERB
admet-2415	182	13	similar	similar	ADJ
admet-2415	182	14	anti	anti	ADJ
admet-2415	182	15	-	-	ADJ
admet-2415	182	16	tumor	tumor	ADJ
admet-2415	182	17	activities	activity	NOUN
admet-2415	182	18	.	.	PUNCT
admet-2415	183	1	this	this	PRON
admet-2415	183	2	could	could	AUX
admet-2415	183	3	be	be	AUX
admet-2415	183	4	understandable	understandable	ADJ
admet-2415	183	5	as	as	ADP
admet-2415	183	6	the	the	DET
admet-2415	183	7	delivery	delivery	NOUN
admet-2415	183	8	systems	system	NOUN
admet-2415	183	9	containing	contain	VERB
admet-2415	183	10	the	the	DET
admet-2415	183	11	same	same	ADJ
admet-2415	183	12	drug	drug	NOUN
admet-2415	183	13	,	,	PUNCT
admet-2415	183	14	ptx	ptx	NOUN
admet-2415	183	15	,	,	PUNCT
admet-2415	183	16	and	and	CCONJ
admet-2415	183	17	the	the	DET
admet-2415	183	18	nanocrystal	nanocrystal	ADJ
admet-2415	183	19	delivery	delivery	NOUN
admet-2415	183	20	systems	system	NOUN
admet-2415	183	21	do	do	AUX
admet-2415	183	22	not	not	PART
admet-2415	183	23	alter	alter	VERB
admet-2415	183	24	the	the	DET
admet-2415	183	25	pharmacodynamics	pharmacodynamic	NOUN
admet-2415	183	26	behavior	behavior	NOUN
admet-2415	183	27	.	.	PUNCT
admet-2415	184	1	it	it	PRON
admet-2415	184	2	also	also	ADV
admet-2415	184	3	suggests	suggest	VERB
admet-2415	184	4	that	that	SCONJ
admet-2415	184	5	a	a	DET
admet-2415	184	6	nanocrystal	nanocrystal	NOUN
admet-2415	184	7	has	have	VERB
admet-2415	184	8	no	no	DET
admet-2415	184	9	antitumor	antitumor	PROPN
admet-2415	184	10	effect	effect	NOUN
admet-2415	184	11	;	;	PUNCT
admet-2415	184	12	it	it	PRON
admet-2415	184	13	is	be	AUX
admet-2415	184	14	released	release	VERB
admet-2415	184	15	or	or	CCONJ
admet-2415	184	16	dissolved	dissolve	VERB
admet-2415	184	17	,	,	PUNCT
admet-2415	184	18	whereby	whereby	SCONJ
admet-2415	184	19	free	free	ADJ
admet-2415	184	20	drug	drug	NOUN
admet-2415	184	21	molecules	molecule	NOUN
admet-2415	184	22	elicit	elicit	VERB
admet-2415	184	23	the	the	DET
admet-2415	184	24	antitumor	antitumor	PROPN
admet-2415	184	25	function	function	NOUN
admet-2415	184	26	.	.	PUNCT
admet-2415	185	1	pbpk	pbpk	PROPN
admet-2415	185	2	/	/	SYM
admet-2415	185	3	pd	pd	PROPN
admet-2415	185	4	simulation	simulation	NOUN
admet-2415	185	5	in	in	ADP
admet-2415	185	6	humans	human	NOUN
admet-2415	185	7	we	we	PRON
admet-2415	185	8	scaled	scale	VERB
admet-2415	185	9	the	the	DET
admet-2415	185	10	pbpk	pbpk	PROPN
admet-2415	185	11	model	model	NOUN
admet-2415	185	12	to	to	ADP
admet-2415	185	13	humans	human	NOUN
admet-2415	185	14	and	and	CCONJ
admet-2415	185	15	conducted	conduct	VERB
admet-2415	185	16	pk	pk	NOUN
admet-2415	185	17	simulations	simulation	NOUN
admet-2415	185	18	under	under	ADP
admet-2415	185	19	hypothetical	hypothetical	ADJ
admet-2415	185	20	conditions	condition	NOUN
admet-2415	185	21	.	.	PUNCT
admet-2415	186	1	the	the	DET
admet-2415	186	2	same	same	ADJ
admet-2415	186	3	partition	partition	NOUN
admet-2415	186	4	coefficients	coefficient	NOUN
admet-2415	186	5	determined	determine	VERB
admet-2415	186	6	by	by	ADP
admet-2415	186	7	data	datum	NOUN
admet-2415	186	8	fitting	fitting	ADJ
admet-2415	186	9	of	of	ADP
admet-2415	186	10	the	the	DET
admet-2415	186	11	murine	murine	ADJ
admet-2415	186	12	model	model	NOUN
admet-2415	186	13	were	be	AUX
admet-2415	186	14	utilized	utilize	VERB
admet-2415	186	15	;	;	PUNCT
admet-2415	186	16	physiological	physiological	ADJ
admet-2415	186	17	parameters	parameter	NOUN
admet-2415	186	18	(	(	PUNCT
admet-2415	186	19	table	table	NOUN
admet-2415	186	20	2	2	NUM
admet-2415	186	21	)	)	PUNCT
admet-2415	186	22	and	and	CCONJ
admet-2415	186	23	the	the	DET
admet-2415	186	24	clearance	clearance	NOUN
admet-2415	186	25	value	value	NOUN
admet-2415	186	26	of	of	ADP
admet-2415	186	27	ptx	ptx	PROPN
admet-2415	186	28	(	(	PUNCT
admet-2415	186	29	25.81	25.81	NUM
admet-2415	186	30	)	)	PUNCT
admet-2415	186	31	in	in	ADP
admet-2415	186	32	humans	human	NOUN
admet-2415	186	33	were	be	AUX
admet-2415	186	34	taken	take	VERB
admet-2415	186	35	from	from	ADP
admet-2415	186	36	the	the	DET
admet-2415	186	37	literature	literature	NOUN
admet-2415	186	38	[	[	X
admet-2415	186	39	34	34	NUM
admet-2415	186	40	]	]	PUNCT
admet-2415	186	41	.	.	PUNCT
admet-2415	187	1	the	the	DET
admet-2415	187	2	simulation	simulation	NOUN
admet-2415	187	3	results	result	NOUN
admet-2415	187	4	of	of	ADP
admet-2415	187	5	the	the	DET
admet-2415	187	6	tumor	tumor	NOUN
admet-2415	187	7	compartment	compartment	NOUN
admet-2415	187	8	are	be	AUX
admet-2415	187	9	shown	show	VERB
admet-2415	187	10	in	in	ADP
admet-2415	187	11	figure	figure	NOUN
admet-2415	187	12	4	4	NUM
admet-2415	187	13	.	.	PUNCT
admet-2415	188	1	the	the	DET
admet-2415	188	2	initial	initial	ADJ
admet-2415	188	3	spikes	spike	NOUN
admet-2415	188	4	of	of	ADP
admet-2415	188	5	concentration	concentration	NOUN
admet-2415	188	6	were	be	AUX
admet-2415	188	7	likely	likely	ADV
admet-2415	188	8	caused	cause	VERB
admet-2415	188	9	by	by	ADP
admet-2415	188	10	the	the	DET
admet-2415	188	11	mathematical	mathematical	ADJ
admet-2415	188	12	model	model	NOUN
admet-2415	188	13	originally	originally	ADV
admet-2415	188	14	generated	generate	VERB
admet-2415	188	15	by	by	ADP
admet-2415	188	16	data	datum	NOUN
admet-2415	188	17	fitting	fitting	ADJ
admet-2415	188	18	of	of	ADP
admet-2415	188	19	experimental	experimental	ADJ
admet-2415	188	20	results	result	NOUN
admet-2415	188	21	obtained	obtain	VERB
admet-2415	188	22	in	in	ADP
admet-2415	188	23	mice	mouse	NOUN
admet-2415	188	24	.	.	PUNCT
admet-2415	189	1	the	the	DET
admet-2415	189	2	remaining	remain	VERB
admet-2415	189	3	trends	trend	NOUN
admet-2415	189	4	appear	appear	VERB
admet-2415	189	5	more	more	ADV
admet-2415	189	6	trustworthy	trustworthy	ADJ
admet-2415	189	7	;	;	PUNCT
admet-2415	189	8	thus	thus	ADV
admet-2415	189	9	,	,	PUNCT
admet-2415	189	10	only	only	ADV
admet-2415	189	11	the	the	DET
admet-2415	189	12	auc	auc	NOUN
admet-2415	189	13	should	should	AUX
admet-2415	189	14	be	be	AUX
admet-2415	189	15	used	use	VERB
admet-2415	189	16	to	to	PART
admet-2415	189	17	interpret	interpret	VERB
admet-2415	189	18	the	the	DET
admet-2415	189	19	simulation	simulation	NOUN
admet-2415	189	20	results	result	NOUN
admet-2415	189	21	.	.	PUNCT
admet-2415	190	1	the	the	DET
admet-2415	190	2	auc	auc	ADJ
admet-2415	190	3	values	value	NOUN
admet-2415	190	4	of	of	ADP
admet-2415	190	5	drug	drug	NOUN
admet-2415	190	6	accumulation	accumulation	NOUN
admet-2415	190	7	in	in	ADP
admet-2415	190	8	tumors	tumor	NOUN
admet-2415	190	9	are	be	AUX
admet-2415	190	10	1.54	1.54	NUM
admet-2415	190	11	,	,	PUNCT
admet-2415	190	12	1.16	1.16	NUM
admet-2415	190	13	,	,	PUNCT
admet-2415	190	14	and	and	CCONJ
admet-2415	190	15	3.52	3.52	NUM
admet-2415	190	16	µg	µg	NOUN
admet-2415	190	17	/	/	SYM
admet-2415	190	18	ml·h	ml·h	NUM
admet-2415	190	19	of	of	ADP
admet-2415	190	20	taxol	taxol	PROPN
admet-2415	190	21	,	,	PUNCT
admet-2415	190	22	ptx	ptx	PROPN
admet-2415	190	23	-	-	PUNCT
admet-2415	190	24	nc	nc	PROPN
admet-2415	190	25	,	,	PUNCT
admet-2415	190	26	and	and	CCONJ
admet-2415	190	27	f68	f68	ADJ
admet-2415	190	28	-	-	PUNCT
admet-2415	190	29	ptx	ptx	NOUN
admet-2415	190	30	-	-	PUNCT
admet-2415	190	31	nc	nc	NOUN
admet-2415	190	32	,	,	PUNCT
admet-2415	190	33	respectively	respectively	ADV
admet-2415	190	34	.	.	PUNCT
admet-2415	191	1	the	the	DET
admet-2415	191	2	surface	surface	NOUN
admet-2415	191	3	treatment	treatment	NOUN
admet-2415	191	4	seems	seem	VERB
admet-2415	191	5	to	to	PART
admet-2415	191	6	at	at	ADV
admet-2415	191	7	least	least	ADJ
admet-2415	191	8	double	double	ADJ
admet-2415	191	9	tu	tu	PROPN
admet-2415	191	10	m	m	NOUN
admet-2415	191	11	o	o	NOUN
admet-2415	191	12	r	r	NOUN
admet-2415	191	13	w	w	PROPN
admet-2415	191	14	ei	ei	PROPN
admet-2415	191	15	gh	gh	PROPN
admet-2415	191	16	t	t	PROPN
admet-2415	191	17	,	,	PUNCT
admet-2415	191	18	g	g	PROPN
admet-2415	191	19	admet	admet	PROPN
admet-2415	191	20	&	&	CCONJ
admet-2415	191	21	dmpk	dmpk	PROPN
admet-2415	191	22	12(5	12(5	NUM
admet-2415	191	23	)	)	PUNCT
admet-2415	191	24	(	(	PUNCT
admet-2415	191	25	2024	2024	NUM
admet-2415	191	26	)	)	PUNCT
admet-2415	191	27	705	705	NUM
admet-2415	191	28	-	-	SYM
admet-2415	191	29	719	719	NUM
admet-2415	191	30	drug	drug	NOUN
admet-2415	191	31	delivery	delivery	NOUN
admet-2415	191	32	to	to	ADP
admet-2415	191	33	tumor	tumor	NOUN
admet-2415	191	34	by	by	ADP
admet-2415	191	35	nanoparticles	nanoparticle	NOUN
admet-2415	191	36	doi	doi	NOUN
admet-2415	191	37	:	:	PUNCT
admet-2415	191	38	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	191	39	713	713	NUM
admet-2415	191	40	the	the	DET
admet-2415	191	41	drug	drug	NOUN
admet-2415	191	42	accumulation	accumulation	NOUN
admet-2415	191	43	in	in	ADP
admet-2415	191	44	tumors	tumor	NOUN
admet-2415	191	45	compared	compare	VERB
admet-2415	191	46	with	with	ADP
admet-2415	191	47	the	the	DET
admet-2415	191	48	solubilized	solubilize	VERB
admet-2415	191	49	formulation	formulation	NOUN
admet-2415	191	50	or	or	CCONJ
admet-2415	191	51	pure	pure	ADJ
admet-2415	191	52	ncs	nc	NOUN
admet-2415	191	53	.	.	PUNCT
admet-2415	192	1	relative	relative	ADJ
admet-2415	192	2	to	to	ADP
admet-2415	192	3	the	the	DET
admet-2415	192	4	total	total	ADJ
admet-2415	192	5	injected	inject	VERB
admet-2415	192	6	dose	dose	NOUN
admet-2415	192	7	(	(	PUNCT
admet-2415	192	8	316	316	NUM
admet-2415	192	9	mg	mg	NOUN
admet-2415	192	10	for	for	ADP
admet-2415	192	11	70	70	NUM
admet-2415	192	12	kg	kg	NOUN
admet-2415	192	13	adult	adult	NOUN
admet-2415	192	14	with	with	ADP
admet-2415	192	15	body	body	NOUN
admet-2415	192	16	surface	surface	NOUN
admet-2415	192	17	area	area	NOUN
admet-2415	192	18	1.7	1.7	NUM
admet-2415	192	19	m2	m2	NOUN
admet-2415	192	20	)	)	PUNCT
admet-2415	192	21	,	,	PUNCT
admet-2415	192	22	the	the	DET
admet-2415	192	23	tumor	tumor	NOUN
admet-2415	192	24	accumulation	accumulation	NOUN
admet-2415	192	25	was	be	AUX
admet-2415	192	26	0.29	0.29	NUM
admet-2415	192	27	,	,	PUNCT
admet-2415	192	28	0.44	0.44	NUM
admet-2415	192	29	,	,	PUNCT
admet-2415	192	30	and	and	CCONJ
admet-2415	192	31	0.95	0.95	NUM
admet-2415	192	32	%	%	NOUN
admet-2415	192	33	.	.	PUNCT
admet-2415	193	1	the	the	DET
admet-2415	193	2	trend	trend	NOUN
admet-2415	193	3	is	be	AUX
admet-2415	193	4	similar	similar	ADJ
admet-2415	193	5	to	to	ADP
admet-2415	193	6	that	that	PRON
admet-2415	193	7	in	in	ADP
admet-2415	193	8	mice	mouse	NOUN
admet-2415	193	9	(	(	PUNCT
admet-2415	193	10	0.62	0.62	NUM
admet-2415	193	11	,	,	PUNCT
admet-2415	193	12	0.26	0.26	NUM
admet-2415	193	13	,	,	PUNCT
admet-2415	193	14	and	and	CCONJ
admet-2415	193	15	2.92	2.92	NUM
admet-2415	193	16	%	%	NOUN
admet-2415	193	17	)	)	PUNCT
admet-2415	193	18	.	.	PUNCT
admet-2415	194	1	the	the	DET
admet-2415	194	2	further	further	ADJ
admet-2415	194	3	increase	increase	NOUN
admet-2415	194	4	in	in	ADP
admet-2415	194	5	mice	mouse	NOUN
admet-2415	194	6	for	for	ADP
admet-2415	194	7	f68coated	f68coated	PROPN
admet-2415	194	8	nc	nc	PROPN
admet-2415	194	9	resulted	result	VERB
admet-2415	194	10	from	from	ADP
admet-2415	194	11	the	the	DET
admet-2415	194	12	decreased	decrease	VERB
admet-2415	194	13	clearance	clearance	NOUN
admet-2415	194	14	.	.	PUNCT
admet-2415	195	1	comparison	comparison	NOUN
admet-2415	195	2	of	of	ADP
admet-2415	195	3	other	other	ADJ
admet-2415	195	4	organs	organ	NOUN
admet-2415	195	5	indicates	indicate	VERB
admet-2415	195	6	different	different	ADJ
admet-2415	195	7	trends	trend	NOUN
admet-2415	195	8	between	between	ADP
admet-2415	195	9	mice	mouse	NOUN
admet-2415	195	10	and	and	CCONJ
admet-2415	195	11	humans	human	NOUN
admet-2415	195	12	(	(	PUNCT
admet-2415	195	13	table	table	NOUN
admet-2415	195	14	5	5	NUM
admet-2415	195	15	)	)	PUNCT
admet-2415	195	16	.	.	PUNCT
admet-2415	196	1	each	each	DET
admet-2415	196	2	value	value	NOUN
admet-2415	196	3	in	in	ADP
admet-2415	196	4	the	the	DET
admet-2415	196	5	tablet	tablet	NOUN
admet-2415	196	6	is	be	AUX
admet-2415	196	7	relative	relative	ADJ
admet-2415	196	8	to	to	ADP
admet-2415	196	9	the	the	DET
admet-2415	196	10	total	total	ADJ
admet-2415	196	11	injected	inject	VERB
admet-2415	196	12	dose	dose	NOUN
admet-2415	196	13	,	,	PUNCT
admet-2415	196	14	equivalent	equivalent	ADJ
admet-2415	196	15	to	to	ADP
admet-2415	196	16	the	the	DET
admet-2415	196	17	accumulated	accumulate	VERB
admet-2415	196	18	concentration	concentration	NOUN
admet-2415	196	19	in	in	ADP
admet-2415	196	20	blood	blood	NOUN
admet-2415	196	21	(	(	PUNCT
admet-2415	196	22	i.e.	i.e.	X
admet-2415	196	23	100	100	NUM
admet-2415	196	24	%	%	NOUN
admet-2415	196	25	)	)	PUNCT
admet-2415	196	26	.	.	PUNCT
admet-2415	197	1	time	time	NOUN
admet-2415	197	2	,	,	PUNCT
admet-2415	197	3	h	h	NOUN
admet-2415	197	4	figure	figure	NOUN
admet-2415	197	5	4	4	NUM
admet-2415	197	6	.	.	PUNCT
admet-2415	197	7	pk	pk	NOUN
admet-2415	197	8	simulation	simulation	NOUN
admet-2415	197	9	of	of	ADP
admet-2415	197	10	the	the	DET
admet-2415	197	11	tumor	tumor	NOUN
admet-2415	197	12	compartment	compartment	NOUN
admet-2415	197	13	in	in	ADP
admet-2415	197	14	a	a	DET
admet-2415	197	15	human	human	NOUN
admet-2415	197	16	using	use	VERB
admet-2415	197	17	three	three	NUM
admet-2415	197	18	ptx	ptx	NOUN
admet-2415	197	19	formulations	formulation	NOUN
admet-2415	197	20	(	(	PUNCT
admet-2415	197	21	20	20	NUM
admet-2415	197	22	mg	mg	NUM
admet-2415	197	23	/	/	SYM
admet-2415	197	24	kg	kg	NOUN
admet-2415	197	25	)	)	PUNCT
admet-2415	197	26	over	over	ADP
admet-2415	197	27	3	3	NUM
admet-2415	197	28	h.	h.	NOUN
admet-2415	197	29	the	the	DET
admet-2415	197	30	inset	inset	NOUN
admet-2415	197	31	shows	show	VERB
admet-2415	197	32	a	a	DET
admet-2415	197	33	simulation	simulation	NOUN
admet-2415	197	34	to	to	ADP
admet-2415	197	35	0.5	0.5	NUM
admet-2415	197	36	h.	h.	NOUN
admet-2415	197	37	table	table	NOUN
admet-2415	197	38	5	5	NUM
admet-2415	197	39	.	.	PUNCT
admet-2415	197	40	comparison	comparison	NOUN
admet-2415	197	41	of	of	ADP
admet-2415	197	42	tissue	tissue	NOUN
admet-2415	197	43	partition	partition	NOUN
admet-2415	197	44	between	between	ADP
admet-2415	197	45	mice	mouse	NOUN
admet-2415	197	46	and	and	CCONJ
admet-2415	197	47	humans	human	NOUN
admet-2415	197	48	by	by	ADP
admet-2415	197	49	three	three	NUM
admet-2415	197	50	different	different	ADJ
admet-2415	197	51	treatments	treatment	NOUN
admet-2415	197	52	relative	relative	ADJ
admet-2415	197	53	to	to	ADP
admet-2415	197	54	the	the	DET
admet-2415	197	55	total	total	ADJ
admet-2415	197	56	injected	inject	VERB
admet-2415	197	57	dose	dose	NOUN
admet-2415	197	58	.	.	PUNCT
admet-2415	198	1	relative	relative	ADJ
admet-2415	198	2	mass	mass	PROPN
admet-2415	198	3	to	to	ADP
admet-2415	198	4	that	that	PRON
admet-2415	198	5	in	in	ADP
admet-2415	198	6	blood	blood	NOUN
admet-2415	198	7	,	,	PUNCT
admet-2415	198	8	%	%	INTJ
admet-2415	198	9	mice	mouse	NOUN
admet-2415	198	10	human	human	PROPN
admet-2415	198	11	taxol	taxol	PROPN
admet-2415	198	12	ptx	ptx	PROPN
admet-2415	198	13	-	-	PROPN
admet-2415	198	14	nc	nc	PROPN
admet-2415	198	15	f68	f68	PROPN
admet-2415	198	16	-	-	PUNCT
admet-2415	198	17	ptx	ptx	NOUN
admet-2415	198	18	taxol	taxol	PROPN
admet-2415	198	19	ptx	ptx	PROPN
admet-2415	198	20	-	-	PROPN
admet-2415	198	21	nc	nc	PROPN
admet-2415	198	22	f68	f68	PROPN
admet-2415	198	23	-	-	PUNCT
admet-2415	198	24	ptx	ptx	NOUN
admet-2415	198	25	lung	lung	NOUN
admet-2415	198	26	0.16	0.16	NUM
admet-2415	199	1	0.26	0.26	NUM
admet-2415	199	2	0.19	0.19	NUM
admet-2415	199	3	1.05	1.05	NUM
admet-2415	199	4	4.12	4.12	NUM
admet-2415	199	5	1.61	1.61	NUM
admet-2415	199	6	blood	blood	NOUN
admet-2415	199	7	100	100	NUM
admet-2415	199	8	100	100	NUM
admet-2415	199	9	100	100	NUM
admet-2415	199	10	100	100	NUM
admet-2415	199	11	100	100	NUM
admet-2415	199	12	100	100	NUM
admet-2415	199	13	heart	heart	NOUN
admet-2415	199	14	0.07	0.07	NUM
admet-2415	199	15	0.01	0.01	NUM
admet-2415	199	16	0.02	0.02	NUM
admet-2415	199	17	0.66	0.66	NUM
admet-2415	199	18	0.57	0.57	NUM
admet-2415	199	19	0.19	0.19	NUM
admet-2415	199	20	kidney	kidney	NOUN
admet-2415	199	21	1.69	1.69	NUM
admet-2415	199	22	0.24	0.24	NUM
admet-2415	199	23	0.34	0.34	NUM
admet-2415	199	24	2.81	2.81	NUM
admet-2415	199	25	1.73	1.73	NUM
admet-2415	199	26	0.85	0.85	NUM
admet-2415	199	27	liver	liver	NOUN
admet-2415	199	28	15.89	15.89	NUM
admet-2415	199	29	35.16	35.16	NUM
admet-2415	199	30	64.38	64.38	NUM
admet-2415	199	31	14.26	14.26	NUM
admet-2415	199	32	17.67	17.67	NUM
admet-2415	199	33	18.55	18.55	NUM
admet-2415	199	34	spleen	spleen	NOUN
admet-2415	199	35	0.07	0.07	NUM
admet-2415	199	36	0.23	0.23	NUM
admet-2415	199	37	0.22	0.22	NUM
admet-2415	199	38	0.29	0.29	NUM
admet-2415	199	39	1.77	1.77	NUM
admet-2415	199	40	3.28	3.28	NUM
admet-2415	199	41	tumor	tumor	NOUN
admet-2415	199	42	0.62	0.62	NUM
admet-2415	199	43	0.26	0.26	NUM
admet-2415	199	44	2.92	2.92	NUM
admet-2415	199	45	0.29	0.29	NUM
admet-2415	199	46	0.44	0.44	NUM
admet-2415	199	47	0.95	0.95	NUM
admet-2415	200	1	we	we	PRON
admet-2415	200	2	further	far	ADV
admet-2415	200	3	simulated	simulate	VERB
admet-2415	200	4	pd	pd	PROPN
admet-2415	200	5	in	in	ADP
admet-2415	200	6	humans	human	NOUN
admet-2415	200	7	based	base	VERB
admet-2415	200	8	on	on	ADP
admet-2415	200	9	the	the	DET
admet-2415	200	10	tumor	tumor	NOUN
admet-2415	200	11	exposure	exposure	NOUN
admet-2415	200	12	predicted	predict	VERB
admet-2415	200	13	by	by	ADP
admet-2415	200	14	the	the	DET
admet-2415	200	15	pbpk	pbpk	NOUN
admet-2415	200	16	discussed	discuss	VERB
admet-2415	200	17	above	above	ADV
admet-2415	200	18	.	.	PUNCT
admet-2415	201	1	tumor	tumor	NOUN
admet-2415	201	2	growth	growth	NOUN
admet-2415	201	3	parameters	parameter	NOUN
admet-2415	201	4	were	be	AUX
admet-2415	201	5	taken	take	VERB
admet-2415	201	6	from	from	ADP
admet-2415	201	7	our	our	PRON
admet-2415	201	8	mouse	mouse	NOUN
admet-2415	201	9	model	model	NOUN
admet-2415	201	10	.	.	PUNCT
admet-2415	202	1	data	datum	NOUN
admet-2415	202	2	from	from	ADP
admet-2415	202	3	human	human	ADJ
admet-2415	202	4	breast	breast	NOUN
admet-2415	202	5	tumors	tumor	NOUN
admet-2415	202	6	were	be	AUX
admet-2415	202	7	simulated	simulate	VERB
admet-2415	202	8	with	with	ADP
admet-2415	202	9	the	the	DET
admet-2415	202	10	blood	blood	NOUN
admet-2415	202	11	flow	flow	NOUN
admet-2415	202	12	rate	rate	NOUN
admet-2415	202	13	and	and	CCONJ
admet-2415	202	14	tumor	tumor	NOUN
admet-2415	202	15	volume	volume	NOUN
admet-2415	202	16	taken	take	VERB
admet-2415	202	17	from	from	ADP
admet-2415	202	18	the	the	DET
admet-2415	202	19	literature	literature	NOUN
admet-2415	202	20	(	(	PUNCT
admet-2415	202	21	3.2	3.2	NUM
admet-2415	202	22	l	l	NOUN
admet-2415	202	23	/	/	SYM
admet-2415	202	24	h	h	NOUN
admet-2415	202	25	and	and	CCONJ
admet-2415	202	26	0.00419	0.00419	NUM
admet-2415	202	27	l	l	NOUN
admet-2415	202	28	;	;	PUNCT
admet-2415	202	29	table	table	NOUN
admet-2415	202	30	2	2	NUM
admet-2415	202	31	)	)	PUNCT
admet-2415	202	32	.	.	PUNCT
admet-2415	203	1	note	note	VERB
admet-2415	203	2	that	that	SCONJ
admet-2415	203	3	,	,	PUNCT
admet-2415	203	4	in	in	ADP
admet-2415	203	5	our	our	PRON
admet-2415	203	6	tumor	tumor	NOUN
admet-2415	203	7	-	-	PUNCT
admet-2415	203	8	bearing	bear	VERB
admet-2415	203	9	mice	mouse	NOUN
admet-2415	203	10	(	(	PUNCT
admet-2415	203	11	as	as	ADV
admet-2415	203	12	well	well	ADV
admet-2415	203	13	as	as	ADP
admet-2415	203	14	numerous	numerous	ADJ
admet-2415	203	15	tumor	tumor	NOUN
admet-2415	203	16	murine	murine	ADJ
admet-2415	203	17	models	model	NOUN
admet-2415	203	18	reported	report	VERB
admet-2415	203	19	in	in	ADP
admet-2415	203	20	the	the	DET
admet-2415	203	21	literature	literature	NOUN
admet-2415	203	22	)	)	PUNCT
admet-2415	203	23	,	,	PUNCT
admet-2415	203	24	the	the	DET
admet-2415	203	25	xenografted	xenografted	ADJ
admet-2415	203	26	tumor	tumor	NOUN
admet-2415	203	27	is	be	AUX
admet-2415	203	28	significantly	significantly	ADV
admet-2415	203	29	larger	large	ADJ
admet-2415	203	30	relative	relative	ADJ
admet-2415	203	31	to	to	ADP
admet-2415	203	32	body	body	NOUN
admet-2415	203	33	weight	weight	NOUN
admet-2415	203	34	(	(	PUNCT
admet-2415	203	35	6	6	NUM
admet-2415	203	36	%	%	NOUN
admet-2415	203	37	)	)	PUNCT
admet-2415	204	1	and	and	CCONJ
admet-2415	204	2	,	,	PUNCT
admet-2415	204	3	therefore	therefore	ADV
admet-2415	204	4	,	,	PUNCT
admet-2415	204	5	not	not	PART
admet-2415	204	6	scalable	scalable	ADJ
admet-2415	204	7	in	in	ADP
admet-2415	204	8	humans	human	NOUN
admet-2415	204	9	(	(	PUNCT
admet-2415	204	10	0.007	0.007	NUM
admet-2415	204	11	%	%	NOUN
admet-2415	204	12	;	;	PUNCT
admet-2415	204	13	see	see	VERB
admet-2415	204	14	later	later	ADJ
admet-2415	204	15	discussion	discussion	NOUN
admet-2415	204	16	)	)	PUNCT
admet-2415	204	17	.	.	PUNCT
admet-2415	205	1	figure	figure	NOUN
admet-2415	205	2	5	5	NUM
admet-2415	205	3	shows	show	VERB
admet-2415	205	4	tumor	tumor	NOUN
admet-2415	205	5	growth	growth	NOUN
admet-2415	205	6	inhibition	inhibition	NOUN
admet-2415	205	7	by	by	ADP
admet-2415	205	8	these	these	DET
admet-2415	205	9	treatments	treatment	NOUN
admet-2415	205	10	was	be	AUX
admet-2415	205	11	evident	evident	ADJ
admet-2415	205	12	within	within	ADP
admet-2415	205	13	the	the	DET
admet-2415	205	14	first	first	ADJ
admet-2415	205	15	few	few	ADJ
admet-2415	205	16	hours	hour	NOUN
admet-2415	205	17	(	(	PUNCT
admet-2415	205	18	3.6	3.6	NUM
admet-2415	205	19	,	,	PUNCT
admet-2415	205	20	2.9	2.9	NUM
admet-2415	205	21	,	,	PUNCT
admet-2415	205	22	and	and	CCONJ
admet-2415	205	23	7.5	7.5	NUM
admet-2415	205	24	%	%	NOUN
admet-2415	205	25	with	with	ADP
admet-2415	205	26	taxol	taxol	PROPN
admet-2415	205	27	,	,	PUNCT
admet-2415	205	28	ptx	ptx	PROPN
admet-2415	205	29	-	-	PUNCT
admet-2415	205	30	nc	nc	PROPN
admet-2415	205	31	,	,	PUNCT
admet-2415	205	32	and	and	CCONJ
admet-2415	205	33	f-68	f-68	ADV
admet-2415	205	34	-	-	PUNCT
admet-2415	205	35	ptx	ptx	NOUN
admet-2415	205	36	-	-	PUNCT
admet-2415	205	37	nc	nc	NOUN
admet-2415	205	38	,	,	PUNCT
admet-2415	205	39	respectively	respectively	ADV
admet-2415	205	40	)	)	PUNCT
admet-2415	205	41	.	.	PUNCT
admet-2415	206	1	at	at	ADP
admet-2415	206	2	day	day	NOUN
admet-2415	206	3	5	5	NUM
admet-2415	206	4	,	,	PUNCT
admet-2415	206	5	human	human	ADJ
admet-2415	206	6	breast	breast	NOUN
admet-2415	206	7	tumor	tumor	NOUN
admet-2415	206	8	growth	growth	NOUN
admet-2415	206	9	without	without	ADP
admet-2415	206	10	treatment	treatment	NOUN
admet-2415	206	11	increased	increase	VERB
admet-2415	206	12	by	by	ADP
admet-2415	206	13	41.2	41.2	NUM
admet-2415	206	14	%	%	NOUN
admet-2415	206	15	,	,	PUNCT
admet-2415	206	16	while	while	SCONJ
admet-2415	206	17	the	the	DET
admet-2415	206	18	increases	increase	NOUN
admet-2415	206	19	were	be	AUX
admet-2415	206	20	31.7	31.7	NUM
admet-2415	206	21	,	,	PUNCT
admet-2415	206	22	33.4	33.4	NUM
admet-2415	206	23	,	,	PUNCT
admet-2415	206	24	26.3	26.3	NUM
admet-2415	206	25	%	%	NOUN
admet-2415	206	26	of	of	ADP
admet-2415	206	27	taxol	taxol	PROPN
admet-2415	206	28	,	,	PUNCT
admet-2415	206	29	ptx	ptx	PROPN
admet-2415	206	30	-	-	PUNCT
admet-2415	206	31	nc	nc	PROPN
admet-2415	206	32	,	,	PUNCT
admet-2415	206	33	and	and	CCONJ
admet-2415	206	34	f68	f68	ADJ
admet-2415	206	35	-	-	PUNCT
admet-2415	206	36	ptx	ptx	NOUN
admet-2415	206	37	-	-	PUNCT
admet-2415	206	38	nc	nc	NOUN
admet-2415	206	39	,	,	PUNCT
admet-2415	206	40	respectively	respectively	ADV
admet-2415	206	41	.	.	PUNCT
admet-2415	207	1	in	in	ADP
admet-2415	207	2	comparison	comparison	NOUN
admet-2415	207	3	,	,	PUNCT
admet-2415	207	4	the	the	DET
admet-2415	207	5	tumor	tumor	NOUN
admet-2415	207	6	growth	growth	NOUN
admet-2415	207	7	during	during	ADP
admet-2415	207	8	a	a	DET
admet-2415	207	9	5	5	NUM
admet-2415	207	10	-	-	PUNCT
admet-2415	207	11	day	day	NOUN
admet-2415	207	12	span	span	NOUN
admet-2415	207	13	in	in	ADP
admet-2415	207	14	mice	mouse	NOUN
admet-2415	207	15	without	without	ADP
admet-2415	207	16	treatment	treatment	NOUN
admet-2415	207	17	was	be	AUX
admet-2415	207	18	270	270	NUM
admet-2415	207	19	and	and	CCONJ
admet-2415	207	20	46	46	NUM
admet-2415	207	21	-	-	SYM
admet-2415	207	22	79	79	NUM
admet-2415	207	23	%	%	NOUN
admet-2415	207	24	with	with	ADP
admet-2415	207	25	the	the	DET
admet-2415	207	26	treatments	treatment	NOUN
admet-2415	207	27	.	.	PUNCT
admet-2415	208	1	the	the	DET
admet-2415	208	2	results	result	NOUN
admet-2415	208	3	d	d	X
admet-2415	208	4	ru	ru	PROPN
admet-2415	208	5	g	g	PROPN
admet-2415	208	6	co	co	PROPN
admet-2415	208	7	n	n	PROPN
admet-2415	208	8	ce	ce	PROPN
admet-2415	208	9	n	n	CCONJ
admet-2415	208	10	tr	tr	VERB
admet-2415	208	11	at	at	ADP
admet-2415	208	12	io	io	X
admet-2415	208	13	n	n	X
admet-2415	208	14	,	,	PUNCT
admet-2415	208	15			NOUN
admet-2415	208	16	g/	g/	NOUN
admet-2415	208	17	m	m	NOUN
admet-2415	208	18	l	l	NOUN
admet-2415	209	1	d	d	NOUN
admet-2415	209	2	ru	ru	PROPN
admet-2415	209	3	g	g	PROPN
admet-2415	209	4	co	co	PROPN
admet-2415	209	5	n	n	PROPN
admet-2415	209	6	ce	ce	PROPN
admet-2415	209	7	n	n	CCONJ
admet-2415	209	8	tr	tr	VERB
admet-2415	209	9	at	at	ADP
admet-2415	209	10	io	io	X
admet-2415	209	11	n	n	X
admet-2415	209	12	,	,	PUNCT
admet-2415	209	13			NOUN
admet-2415	209	14	g/	g/	NOUN
admet-2415	209	15	m	m	NOUN
admet-2415	209	16	l	l	NOUN
admet-2415	209	17	time	time	NOUN
admet-2415	210	1	,	,	PUNCT
admet-2415	210	2	h	h	PROPN
admet-2415	210	3	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	210	4	s.	s.	PROPN
admet-2415	210	5	lu	lu	PROPN
admet-2415	210	6	et	et	PROPN
admet-2415	210	7	al	al	PROPN
admet-2415	210	8	.	.	PROPN
admet-2415	210	9	admet	admet	PROPN
admet-2415	210	10	&	&	CCONJ
admet-2415	210	11	dmpk	dmpk	PROPN
admet-2415	210	12	12(5	12(5	NUM
admet-2415	210	13	)	)	PUNCT
admet-2415	210	14	(	(	PUNCT
admet-2415	210	15	2024	2024	NUM
admet-2415	210	16	)	)	PUNCT
admet-2415	210	17	705	705	NUM
admet-2415	210	18	-	-	SYM
admet-2415	210	19	719	719	NUM
admet-2415	210	20	714	714	NUM
admet-2415	210	21	show	show	VERB
admet-2415	210	22	a	a	DET
admet-2415	210	23	considerable	considerable	ADJ
admet-2415	210	24	difference	difference	NOUN
admet-2415	210	25	in	in	ADP
admet-2415	210	26	tumor	tumor	NOUN
admet-2415	210	27	growth	growth	NOUN
admet-2415	210	28	between	between	ADP
admet-2415	210	29	mice	mouse	NOUN
admet-2415	210	30	and	and	CCONJ
admet-2415	210	31	humans	human	NOUN
admet-2415	210	32	without	without	ADP
admet-2415	210	33	treatment	treatment	NOUN
admet-2415	210	34	.	.	PUNCT
admet-2415	211	1	even	even	ADV
admet-2415	211	2	with	with	ADP
admet-2415	211	3	the	the	DET
admet-2415	211	4	treatment	treatment	NOUN
admet-2415	211	5	,	,	PUNCT
admet-2415	211	6	the	the	DET
admet-2415	211	7	difference	difference	NOUN
admet-2415	211	8	is	be	AUX
admet-2415	211	9	still	still	ADV
admet-2415	211	10	outstanding	outstanding	ADJ
admet-2415	211	11	.	.	PUNCT
admet-2415	212	1	the	the	DET
admet-2415	212	2	simulation	simulation	NOUN
admet-2415	212	3	also	also	ADV
admet-2415	212	4	indicates	indicate	VERB
admet-2415	212	5	that	that	SCONJ
admet-2415	212	6	surface	surface	NOUN
admet-2415	212	7	coating	coating	NOUN
admet-2415	212	8	of	of	ADP
admet-2415	212	9	ncs	ncs	NOUN
admet-2415	212	10	can	can	AUX
admet-2415	212	11	positively	positively	ADV
admet-2415	212	12	inhibit	inhibit	VERB
admet-2415	212	13	tumor	tumor	NOUN
admet-2415	212	14	growth	growth	NOUN
admet-2415	212	15	,	,	PUNCT
admet-2415	212	16	agreeing	agree	VERB
admet-2415	212	17	with	with	ADP
admet-2415	212	18	the	the	DET
admet-2415	212	19	biodistribution	biodistribution	NOUN
admet-2415	212	20	simulation	simulation	NOUN
admet-2415	212	21	(	(	PUNCT
admet-2415	212	22	figure	figure	NOUN
admet-2415	212	23	4	4	NUM
admet-2415	212	24	)	)	PUNCT
admet-2415	212	25	.	.	PUNCT
admet-2415	213	1	time	time	NOUN
admet-2415	213	2	,	,	PUNCT
admet-2415	213	3	day	day	NOUN
admet-2415	213	4	figure	figure	NOUN
admet-2415	213	5	5	5	NUM
admet-2415	213	6	.	.	PUNCT
admet-2415	213	7	human	human	PROPN
admet-2415	213	8	pd	pd	PROPN
admet-2415	213	9	simulation	simulation	NOUN
admet-2415	213	10	of	of	ADP
admet-2415	213	11	three	three	NUM
admet-2415	213	12	paclitaxel	paclitaxel	ADJ
admet-2415	213	13	drug	drug	NOUN
admet-2415	213	14	formulations	formulation	NOUN
admet-2415	213	15	.	.	PUNCT
admet-2415	214	1	sensitivity	sensitivity	NOUN
admet-2415	214	2	analysis	analysis	NOUN
admet-2415	214	3	and	and	CCONJ
admet-2415	214	4	human	human	NOUN
admet-2415	214	5	-	-	PUNCT
admet-2415	214	6	scaling	scale	VERB
admet-2415	214	7	simulation	simulation	NOUN
admet-2415	214	8	sensitivity	sensitivity	NOUN
admet-2415	214	9	analyses	analysis	NOUN
admet-2415	214	10	were	be	AUX
admet-2415	214	11	conducted	conduct	VERB
admet-2415	214	12	to	to	PART
admet-2415	214	13	examine	examine	VERB
admet-2415	214	14	the	the	DET
admet-2415	214	15	impact	impact	NOUN
admet-2415	214	16	of	of	ADP
admet-2415	214	17	individual	individual	ADJ
admet-2415	214	18	pk	pk	NOUN
admet-2415	214	19	parameters	parameter	NOUN
admet-2415	214	20	on	on	ADP
admet-2415	214	21	the	the	DET
admet-2415	214	22	biodistribution	biodistribution	NOUN
admet-2415	214	23	kinetics	kinetic	NOUN
admet-2415	214	24	in	in	ADP
admet-2415	214	25	mice	mouse	NOUN
admet-2415	214	26	and	and	CCONJ
admet-2415	214	27	humans	human	NOUN
admet-2415	214	28	.	.	PUNCT
admet-2415	215	1	figure	figure	VERB
admet-2415	215	2	6	6	NUM
admet-2415	215	3	shows	show	VERB
admet-2415	215	4	the	the	DET
admet-2415	215	5	two	two	NUM
admet-2415	215	6	sensitivity	sensitivity	NOUN
admet-2415	215	7	matrices	matrix	NOUN
admet-2415	215	8	calculated	calculate	VERB
admet-2415	215	9	for	for	ADP
admet-2415	215	10	mice	mouse	NOUN
admet-2415	215	11	and	and	CCONJ
admet-2415	215	12	humans	human	NOUN
admet-2415	215	13	.	.	PUNCT
admet-2415	216	1	the	the	DET
admet-2415	216	2	data	datum	NOUN
admet-2415	216	3	shown	show	VERB
admet-2415	216	4	here	here	ADV
admet-2415	216	5	was	be	AUX
admet-2415	216	6	generated	generate	VERB
admet-2415	216	7	based	base	VERB
admet-2415	216	8	on	on	ADP
admet-2415	216	9	simulations	simulation	NOUN
admet-2415	216	10	of	of	ADP
admet-2415	216	11	taxol	taxol	PROPN
admet-2415	216	12	(	(	PUNCT
admet-2415	216	13	considering	consider	VERB
admet-2415	216	14	the	the	DET
admet-2415	216	15	clearance	clearance	NOUN
admet-2415	216	16	data	datum	NOUN
admet-2415	216	17	taken	take	VERB
admet-2415	216	18	from	from	ADP
admet-2415	216	19	the	the	DET
admet-2415	216	20	study	study	NOUN
admet-2415	216	21	of	of	ADP
admet-2415	216	22	taxol	taxol	PROPN
admet-2415	216	23	)	)	PUNCT
admet-2415	216	24	,	,	PUNCT
admet-2415	216	25	but	but	CCONJ
admet-2415	216	26	the	the	DET
admet-2415	216	27	data	datum	NOUN
admet-2415	216	28	of	of	ADP
admet-2415	216	29	the	the	DET
admet-2415	216	30	other	other	ADJ
admet-2415	216	31	two	two	NUM
admet-2415	216	32	nc	nc	PROPN
admet-2415	216	33	formulations	formulation	NOUN
admet-2415	216	34	(	(	PUNCT
admet-2415	216	35	not	not	PART
admet-2415	216	36	shown	show	VERB
admet-2415	216	37	here	here	ADV
admet-2415	216	38	)	)	PUNCT
admet-2415	216	39	yield	yield	VERB
admet-2415	216	40	the	the	DET
admet-2415	216	41	same	same	ADJ
admet-2415	216	42	trend	trend	NOUN
admet-2415	216	43	and	and	CCONJ
admet-2415	216	44	conclusion	conclusion	NOUN
admet-2415	216	45	.	.	PUNCT
admet-2415	217	1	figure	figure	NOUN
admet-2415	217	2	6	6	NUM
admet-2415	217	3	.	.	PUNCT
admet-2415	218	1	heat	heat	NOUN
admet-2415	218	2	maps	map	NOUN
admet-2415	218	3	or	or	CCONJ
admet-2415	218	4	sensitivity	sensitivity	NOUN
admet-2415	218	5	matrices	matrix	NOUN
admet-2415	218	6	of	of	ADP
admet-2415	218	7	seven	seven	NUM
admet-2415	218	8	organ	organ	NOUN
admet-2415	218	9	compartments	compartment	NOUN
admet-2415	218	10	with	with	ADP
admet-2415	218	11	eight	eight	NUM
admet-2415	218	12	pk	pk	NOUN
admet-2415	218	13	parameters	parameter	NOUN
admet-2415	218	14	,	,	PUNCT
admet-2415	218	15	including	include	VERB
admet-2415	218	16	the	the	DET
admet-2415	218	17	partition	partition	NOUN
admet-2415	218	18	coefficient	coefficient	NOUN
admet-2415	218	19	of	of	ADP
admet-2415	218	20	each	each	DET
admet-2415	218	21	compartment	compartment	NOUN
admet-2415	218	22	and	and	CCONJ
admet-2415	218	23	liver	liver	NOUN
admet-2415	218	24	clearance	clearance	NOUN
admet-2415	218	25	in	in	ADP
admet-2415	218	26	mice	mouse	NOUN
admet-2415	218	27	(	(	PUNCT
admet-2415	218	28	a	a	NOUN
admet-2415	218	29	)	)	PUNCT
admet-2415	218	30	and	and	CCONJ
admet-2415	218	31	in	in	ADP
admet-2415	218	32	humans	human	NOUN
admet-2415	218	33	(	(	PUNCT
admet-2415	218	34	b	b	NOUN
admet-2415	218	35	)	)	PUNCT
admet-2415	218	36	.	.	PUNCT
admet-2415	219	1	pk	pk	NOUN
admet-2415	219	2	parameters	parameter	NOUN
admet-2415	219	3	are	be	AUX
admet-2415	219	4	shown	show	VERB
admet-2415	219	5	along	along	ADP
admet-2415	219	6	the	the	DET
admet-2415	219	7	x	x	NOUN
admet-2415	219	8	-	-	ADJ
admet-2415	219	9	axis	axis	ADJ
admet-2415	219	10	and	and	CCONJ
admet-2415	219	11	drug	drug	NOUN
admet-2415	219	12	concentrations	concentration	NOUN
admet-2415	219	13	in	in	ADP
admet-2415	219	14	the	the	DET
admet-2415	219	15	organs	organ	NOUN
admet-2415	219	16	are	be	AUX
admet-2415	219	17	shown	show	VERB
admet-2415	219	18	along	along	ADP
admet-2415	219	19	the	the	DET
admet-2415	219	20	y	y	NOUN
admet-2415	219	21	-	-	PUNCT
admet-2415	219	22	axis	axis	NOUN
admet-2415	219	23	.	.	PUNCT
admet-2415	220	1	values	value	NOUN
admet-2415	220	2	are	be	AUX
admet-2415	220	3	sensitivities	sensitivity	NOUN
admet-2415	220	4	accumulated	accumulate	VERB
admet-2415	220	5	over	over	ADP
admet-2415	220	6	3	3	NUM
admet-2415	220	7	hr	hr	NOUN
admet-2415	220	8	.	.	PUNCT
admet-2415	221	1	the	the	DET
admet-2415	221	2	heat	heat	NOUN
admet-2415	221	3	map	map	NOUN
admet-2415	221	4	indicates	indicate	VERB
admet-2415	221	5	intercorrelations	intercorrelation	NOUN
admet-2415	221	6	between	between	ADP
admet-2415	221	7	pbpk	pbpk	ADJ
admet-2415	221	8	parameters	parameter	NOUN
admet-2415	221	9	and	and	CCONJ
admet-2415	221	10	drug	drug	NOUN
admet-2415	221	11	concentrations	concentration	NOUN
admet-2415	221	12	in	in	ADP
admet-2415	221	13	the	the	DET
admet-2415	221	14	organs	organ	NOUN
admet-2415	221	15	and	and	CCONJ
admet-2415	221	16	tumor	tumor	NOUN
admet-2415	221	17	.	.	PUNCT
admet-2415	222	1	for	for	ADP
admet-2415	222	2	the	the	DET
admet-2415	222	3	drug	drug	NOUN
admet-2415	222	4	concentration	concentration	NOUN
admet-2415	222	5	in	in	ADP
admet-2415	222	6	a	a	DET
admet-2415	222	7	particular	particular	ADJ
admet-2415	222	8	organ	organ	NOUN
admet-2415	222	9	(	(	PUNCT
admet-2415	222	10	i.e.	i.e.	X
admet-2415	222	11	the	the	DET
admet-2415	222	12	y	y	NOUN
admet-2415	222	13	-	-	PUNCT
admet-2415	222	14	axis	axis	NOUN
admet-2415	222	15	)	)	PUNCT
admet-2415	222	16	,	,	PUNCT
admet-2415	222	17	the	the	DET
admet-2415	222	18	figure	figure	NOUN
admet-2415	222	19	ranks	rank	VERB
admet-2415	222	20	the	the	DET
admet-2415	222	21	significance	significance	NOUN
admet-2415	222	22	of	of	ADP
admet-2415	222	23	impact	impact	NOUN
admet-2415	222	24	by	by	ADP
admet-2415	222	25	the	the	DET
admet-2415	222	26	respective	respective	ADJ
admet-2415	222	27	partition	partition	NOUN
admet-2415	222	28	coefficient	coefficient	NOUN
admet-2415	222	29	and	and	CCONJ
admet-2415	222	30	hepatic	hepatic	ADJ
admet-2415	222	31	clearance	clearance	NOUN
admet-2415	222	32	(	(	PUNCT
admet-2415	222	33	x	x	NOUN
admet-2415	222	34	-	-	NOUN
admet-2415	222	35	axis	axis	ADJ
admet-2415	222	36	)	)	PUNCT
admet-2415	222	37	.	.	PUNCT
admet-2415	223	1	each	each	DET
admet-2415	223	2	box	box	NOUN
admet-2415	223	3	's	's	PART
admet-2415	223	4	color	color	NOUN
admet-2415	223	5	marks	mark	VERB
admet-2415	223	6	the	the	DET
admet-2415	223	7	sensitivity	sensitivity	NOUN
admet-2415	223	8	values	value	NOUN
admet-2415	223	9	of	of	ADP
admet-2415	223	10	a	a	DET
admet-2415	223	11	particular	particular	ADJ
admet-2415	223	12	derivative	derivative	NOUN
admet-2415	223	13	of	of	ADP
admet-2415	223	14	organ	organ	NOUN
admet-2415	223	15	concentration	concentration	NOUN
admet-2415	223	16	over	over	ADP
admet-2415	223	17	partition	partition	NOUN
admet-2415	223	18	coefficient	coefficient	NOUN
admet-2415	223	19	or	or	CCONJ
admet-2415	223	20	clearance	clearance	NOUN
admet-2415	223	21	,	,	PUNCT
admet-2415	223	22	integrated	integrate	VERB
admet-2415	223	23	over	over	ADP
admet-2415	223	24	a	a	DET
admet-2415	223	25	period	period	NOUN
admet-2415	223	26	of	of	ADP
admet-2415	223	27	time	time	NOUN
admet-2415	223	28	(	(	PUNCT
admet-2415	223	29	e.g.	e.g.	ADV
admet-2415	223	30	3	3	NUM
admet-2415	223	31	h	h	NOUN
admet-2415	223	32	used	use	VERB
admet-2415	223	33	in	in	ADP
admet-2415	223	34	figure	figure	NOUN
admet-2415	223	35	6	6	NUM
admet-2415	223	36	)	)	PUNCT
admet-2415	223	37	.	.	PUNCT
admet-2415	224	1	the	the	DET
admet-2415	224	2	sensitivity	sensitivity	NOUN
admet-2415	224	3	map	map	NOUN
admet-2415	224	4	calculated	calculate	VERB
admet-2415	224	5	from	from	ADP
admet-2415	224	6	the	the	DET
admet-2415	224	7	mice	mouse	NOUN
admet-2415	224	8	pk	pk	NOUN
admet-2415	224	9	model	model	NOUN
admet-2415	224	10	(	(	PUNCT
admet-2415	224	11	figure	figure	VERB
admet-2415	224	12	6a	6a	NOUN
admet-2415	224	13	)	)	PUNCT
admet-2415	224	14	indicates	indicate	VERB
admet-2415	224	15	that	that	SCONJ
admet-2415	224	16	the	the	DET
admet-2415	224	17	hepatic	hepatic	ADJ
admet-2415	224	18	clearance	clearance	NOUN
admet-2415	224	19	of	of	ADP
admet-2415	224	20	ptx	ptx	NOUN
admet-2415	224	21	is	be	AUX
admet-2415	224	22	the	the	DET
admet-2415	224	23	dominant	dominant	ADJ
admet-2415	224	24	factor	factor	NOUN
admet-2415	224	25	in	in	ADP
admet-2415	224	26	determining	determine	VERB
admet-2415	224	27	drug	drug	NOUN
admet-2415	224	28	depositions	deposition	NOUN
admet-2415	224	29	in	in	ADP
admet-2415	224	30	all	all	DET
admet-2415	224	31	organs	organ	NOUN
admet-2415	224	32	and	and	CCONJ
admet-2415	224	33	the	the	DET
admet-2415	224	34	tumor	tumor	NOUN
admet-2415	224	35	.	.	PUNCT
admet-2415	225	1	the	the	DET
admet-2415	225	2	plasma	plasma	NOUN
admet-2415	225	3	concentration	concentration	NOUN
admet-2415	225	4	of	of	ADP
admet-2415	225	5	the	the	DET
admet-2415	225	6	drug	drug	NOUN
admet-2415	225	7	is	be	AUX
admet-2415	225	8	affected	affect	VERB
admet-2415	225	9	mainly	mainly	ADV
admet-2415	225	10	by	by	ADP
admet-2415	225	11	the	the	DET
admet-2415	225	12	kht	kht	PROPN
admet-2415	225	13	kkd	kkd	PROPN
admet-2415	225	14	kli	kli	PROPN
admet-2415	225	15	klu	klu	PROPN
admet-2415	225	16	ksp	ksp	PROPN
admet-2415	225	17	ktu	ktu	PROPN
admet-2415	225	18	clearance	clearance	PROPN
admet-2415	225	19	kht	kht	PROPN
admet-2415	225	20	kkd	kkd	PROPN
admet-2415	225	21	kli	kli	PROPN
admet-2415	225	22	klu	klu	PROPN
admet-2415	225	23	ksp	ksp	PROPN
admet-2415	225	24	ktu	ktu	PROPN
admet-2415	225	25	clearance	clearance	PROPN
admet-2415	225	26	cbl	cbl	PROPN
admet-2415	225	27	cht	cht	PROPN
admet-2415	225	28	ckd	ckd	PROPN
admet-2415	225	29	cli	cli	PROPN
admet-2415	225	30	clu	clu	PROPN
admet-2415	225	31	csp	csp	PROPN
admet-2415	225	32	ctu	ctu	PROPN
admet-2415	225	33	cbl	cbl	PROPN
admet-2415	225	34	cht	cht	PROPN
admet-2415	225	35	ckd	ckd	PROPN
admet-2415	225	36	cli	cli	PROPN
admet-2415	225	37	clu	clu	PROPN
admet-2415	225	38	csp	csp	PROPN
admet-2415	225	39	ctu	ctu	PROPN
admet-2415	225	40	tu	tu	PROPN
admet-2415	225	41	m	m	PROPN
admet-2415	225	42	o	o	NOUN
admet-2415	225	43	r	r	NOUN
admet-2415	225	44	w	w	PROPN
admet-2415	225	45	ei	ei	PROPN
admet-2415	225	46	gh	gh	PROPN
admet-2415	225	47	t	t	PROPN
admet-2415	225	48	,	,	PUNCT
admet-2415	225	49	g	g	PROPN
admet-2415	225	50	admet	admet	PROPN
admet-2415	225	51	&	&	CCONJ
admet-2415	225	52	dmpk	dmpk	PROPN
admet-2415	225	53	12(5	12(5	NUM
admet-2415	225	54	)	)	PUNCT
admet-2415	225	55	(	(	PUNCT
admet-2415	225	56	2024	2024	NUM
admet-2415	225	57	)	)	PUNCT
admet-2415	225	58	705	705	NUM
admet-2415	225	59	-	-	SYM
admet-2415	225	60	719	719	NUM
admet-2415	225	61	drug	drug	NOUN
admet-2415	225	62	delivery	delivery	NOUN
admet-2415	225	63	to	to	ADP
admet-2415	225	64	tumor	tumor	NOUN
admet-2415	225	65	by	by	ADP
admet-2415	225	66	nanoparticles	nanoparticle	NOUN
admet-2415	225	67	doi	doi	NOUN
admet-2415	225	68	:	:	PUNCT
admet-2415	225	69	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	225	70	715	715	NUM
admet-2415	225	71	hepatic	hepatic	ADJ
admet-2415	225	72	clearance	clearance	NOUN
admet-2415	225	73	.	.	PUNCT
admet-2415	226	1	the	the	DET
admet-2415	226	2	next	next	ADJ
admet-2415	226	3	organ	organ	NOUN
admet-2415	226	4	affected	affect	VERB
admet-2415	226	5	by	by	ADP
admet-2415	226	6	the	the	DET
admet-2415	226	7	clearance	clearance	NOUN
admet-2415	226	8	is	be	AUX
admet-2415	226	9	the	the	DET
admet-2415	226	10	liver	liver	NOUN
admet-2415	226	11	,	,	PUNCT
admet-2415	226	12	followed	follow	VERB
admet-2415	226	13	by	by	ADP
admet-2415	226	14	the	the	DET
admet-2415	226	15	lung	lung	NOUN
admet-2415	226	16	.	.	PUNCT
admet-2415	227	1	from	from	ADP
admet-2415	227	2	the	the	DET
admet-2415	227	3	mathematic	mathematic	ADJ
admet-2415	227	4	and	and	CCONJ
admet-2415	227	5	modeling	modeling	NOUN
admet-2415	227	6	perspective	perspective	NOUN
admet-2415	227	7	,	,	PUNCT
admet-2415	227	8	the	the	DET
admet-2415	227	9	drug	drug	NOUN
admet-2415	227	10	concentration	concentration	NOUN
admet-2415	227	11	accumulated	accumulate	VERB
admet-2415	227	12	in	in	ADP
admet-2415	227	13	an	an	DET
admet-2415	227	14	organ	organ	NOUN
admet-2415	227	15	is	be	AUX
admet-2415	227	16	positively	positively	ADV
admet-2415	227	17	affected	affect	VERB
admet-2415	227	18	by	by	ADP
admet-2415	227	19	the	the	DET
admet-2415	227	20	blood	blood	NOUN
admet-2415	227	21	flow	flow	NOUN
admet-2415	227	22	rate	rate	NOUN
admet-2415	227	23	to	to	ADP
admet-2415	227	24	the	the	DET
admet-2415	227	25	organ	organ	NOUN
admet-2415	227	26	and	and	CCONJ
admet-2415	227	27	negatively	negatively	ADV
admet-2415	227	28	by	by	ADP
admet-2415	227	29	the	the	DET
admet-2415	227	30	organ	organ	NOUN
admet-2415	227	31	volume	volume	NOUN
admet-2415	227	32	(	(	PUNCT
admet-2415	227	33	or	or	CCONJ
admet-2415	227	34	weight	weight	NOUN
admet-2415	227	35	)	)	PUNCT
admet-2415	227	36	.	.	PUNCT
admet-2415	228	1	the	the	DET
admet-2415	228	2	lung	lung	NOUN
admet-2415	228	3	has	have	VERB
admet-2415	228	4	the	the	DET
admet-2415	228	5	highest	high	ADJ
admet-2415	228	6	blood	blood	NOUN
admet-2415	228	7	flow	flow	NOUN
admet-2415	228	8	rate	rate	NOUN
admet-2415	228	9	,	,	PUNCT
admet-2415	228	10	followed	follow	VERB
admet-2415	228	11	by	by	ADP
admet-2415	228	12	the	the	DET
admet-2415	228	13	liver	liver	NOUN
admet-2415	228	14	.	.	PUNCT
admet-2415	229	1	this	this	PRON
admet-2415	229	2	can	can	AUX
admet-2415	229	3	be	be	AUX
admet-2415	229	4	further	far	ADV
admet-2415	229	5	illustrated	illustrate	VERB
admet-2415	229	6	by	by	ADP
admet-2415	229	7	comparing	compare	VERB
admet-2415	229	8	drug	drug	NOUN
admet-2415	229	9	accumulations	accumulation	NOUN
admet-2415	229	10	in	in	ADP
admet-2415	229	11	tumors	tumor	NOUN
admet-2415	229	12	and	and	CCONJ
admet-2415	229	13	the	the	DET
admet-2415	229	14	liver	liver	NOUN
admet-2415	229	15	.	.	PUNCT
admet-2415	230	1	the	the	DET
admet-2415	230	2	tumor	tumor	NOUN
admet-2415	230	3	has	have	VERB
admet-2415	230	4	a	a	DET
admet-2415	230	5	comparable	comparable	ADJ
admet-2415	230	6	organ	organ	NOUN
admet-2415	230	7	volume	volume	NOUN
admet-2415	230	8	to	to	ADP
admet-2415	230	9	the	the	DET
admet-2415	230	10	liver	liver	NOUN
admet-2415	230	11	or	or	CCONJ
admet-2415	230	12	blood	blood	NOUN
admet-2415	230	13	,	,	PUNCT
admet-2415	230	14	but	but	CCONJ
admet-2415	230	15	its	its	PRON
admet-2415	230	16	flow	flow	NOUN
admet-2415	230	17	rate	rate	NOUN
admet-2415	230	18	is	be	AUX
admet-2415	230	19	only	only	ADV
admet-2415	230	20	a	a	DET
admet-2415	230	21	fraction	fraction	NOUN
admet-2415	230	22	of	of	ADP
admet-2415	230	23	that	that	PRON
admet-2415	230	24	in	in	ADP
admet-2415	230	25	the	the	DET
admet-2415	230	26	liver	liver	NOUN
admet-2415	230	27	or	or	CCONJ
admet-2415	230	28	blood	blood	NOUN
admet-2415	230	29	(	(	PUNCT
admet-2415	230	30	about	about	ADV
admet-2415	230	31	0.9	0.9	NUM
admet-2415	230	32	%	%	NOUN
admet-2415	230	33	or	or	CCONJ
admet-2415	230	34	0.2	0.2	NUM
admet-2415	230	35	%	%	NOUN
admet-2415	230	36	;	;	PUNCT
admet-2415	230	37	table	table	NOUN
admet-2415	230	38	1	1	NUM
admet-2415	230	39	)	)	PUNCT
admet-2415	230	40	.	.	PUNCT
admet-2415	231	1	besides	besides	SCONJ
admet-2415	231	2	the	the	DET
admet-2415	231	3	phagocytosis	phagocytosis	NOUN
admet-2415	231	4	of	of	ADP
admet-2415	231	5	drug	drug	NOUN
admet-2415	231	6	nanocrystals	nanocrystal	NOUN
admet-2415	231	7	by	by	ADP
admet-2415	231	8	the	the	DET
admet-2415	231	9	mps	mps	PROPN
admet-2415	231	10	(	(	PUNCT
admet-2415	231	11	indicated	indicate	VERB
admet-2415	231	12	by	by	ADP
admet-2415	231	13	the	the	DET
admet-2415	231	14	liver	liver	NOUN
admet-2415	231	15	partition	partition	NOUN
admet-2415	231	16	coefficient	coefficient	NOUN
admet-2415	231	17	)	)	PUNCT
admet-2415	231	18	,	,	PUNCT
admet-2415	231	19	the	the	DET
admet-2415	231	20	much	much	ADV
admet-2415	231	21	-	-	PUNCT
admet-2415	231	22	dwarfed	dwarfed	ADJ
admet-2415	231	23	systemic	systemic	ADJ
admet-2415	231	24	circulation	circulation	NOUN
admet-2415	231	25	into	into	ADP
admet-2415	231	26	the	the	DET
admet-2415	231	27	tumor	tumor	NOUN
admet-2415	231	28	significantly	significantly	ADV
admet-2415	231	29	limits	limit	VERB
admet-2415	231	30	drug	drug	NOUN
admet-2415	231	31	deposition	deposition	NOUN
admet-2415	231	32	.	.	PUNCT
admet-2415	232	1	nonetheless	nonetheless	ADV
admet-2415	232	2	,	,	PUNCT
admet-2415	232	3	despite	despite	SCONJ
admet-2415	232	4	the	the	DET
admet-2415	232	5	liver	liver	NOUN
admet-2415	232	6	partition	partition	NOUN
admet-2415	232	7	being	be	AUX
admet-2415	232	8	the	the	DET
admet-2415	232	9	largest	large	ADJ
admet-2415	232	10	among	among	ADP
admet-2415	232	11	all	all	DET
admet-2415	232	12	partition	partition	NOUN
admet-2415	232	13	coefficients	coefficient	NOUN
admet-2415	232	14	(	(	PUNCT
admet-2415	232	15	table	table	NOUN
admet-2415	232	16	3	3	NUM
admet-2415	232	17	)	)	PUNCT
admet-2415	232	18	,	,	PUNCT
admet-2415	232	19	it	it	PRON
admet-2415	232	20	is	be	AUX
admet-2415	232	21	the	the	DET
admet-2415	232	22	systemic	systemic	ADJ
admet-2415	232	23	clearance	clearance	NOUN
admet-2415	232	24	by	by	ADP
admet-2415	232	25	the	the	DET
admet-2415	232	26	liver	liver	NOUN
admet-2415	232	27	that	that	PRON
admet-2415	232	28	exaggerates	exaggerate	VERB
admet-2415	232	29	the	the	DET
admet-2415	232	30	liver	liver	NOUN
admet-2415	232	31	partition	partition	NOUN
admet-2415	232	32	in	in	ADP
admet-2415	232	33	determining	determine	VERB
admet-2415	232	34	local	local	ADJ
admet-2415	232	35	drug	drug	NOUN
admet-2415	232	36	distributions	distribution	NOUN
admet-2415	232	37	to	to	ADP
admet-2415	232	38	other	other	ADJ
admet-2415	232	39	organs	organ	NOUN
admet-2415	232	40	and	and	CCONJ
admet-2415	232	41	the	the	DET
admet-2415	232	42	tumor	tumor	NOUN
admet-2415	232	43	.	.	PUNCT
admet-2415	233	1	figure	figure	NOUN
admet-2415	233	2	6b	6b	PROPN
admet-2415	233	3	shows	show	VERB
admet-2415	233	4	the	the	DET
admet-2415	233	5	sensitivity	sensitivity	NOUN
admet-2415	233	6	matrix	matrix	NOUN
admet-2415	233	7	in	in	ADP
admet-2415	233	8	humans	human	NOUN
admet-2415	233	9	.	.	PUNCT
admet-2415	234	1	the	the	DET
admet-2415	234	2	same	same	ADJ
admet-2415	234	3	partition	partition	NOUN
admet-2415	234	4	coefficients	coefficient	NOUN
admet-2415	234	5	determined	determine	VERB
admet-2415	234	6	from	from	ADP
admet-2415	234	7	the	the	DET
admet-2415	234	8	mice	mice	NOUN
admet-2415	234	9	model	model	NOUN
admet-2415	234	10	were	be	AUX
admet-2415	234	11	utilized	utilize	VERB
admet-2415	234	12	but	but	CCONJ
admet-2415	234	13	with	with	ADP
admet-2415	234	14	human	human	ADJ
admet-2415	234	15	physiological	physiological	ADJ
admet-2415	234	16	conditions	condition	NOUN
admet-2415	234	17	(	(	PUNCT
admet-2415	234	18	table	table	NOUN
admet-2415	234	19	2	2	NUM
admet-2415	234	20	)	)	PUNCT
admet-2415	234	21	.	.	PUNCT
admet-2415	235	1	the	the	DET
admet-2415	235	2	clearance	clearance	NOUN
admet-2415	235	3	was	be	AUX
admet-2415	235	4	taken	take	VERB
admet-2415	235	5	from	from	ADP
admet-2415	235	6	human	human	ADJ
admet-2415	235	7	experimental	experimental	ADJ
admet-2415	235	8	data	datum	NOUN
admet-2415	235	9	for	for	ADP
admet-2415	235	10	paclitaxel	paclitaxel	PROPN
admet-2415	235	11	[	[	X
admet-2415	235	12	34	34	NUM
admet-2415	235	13	]	]	PUNCT
admet-2415	235	14	.	.	PUNCT
admet-2415	236	1	the	the	DET
admet-2415	236	2	overall	overall	ADJ
admet-2415	236	3	result	result	NOUN
admet-2415	236	4	is	be	AUX
admet-2415	236	5	different	different	ADJ
admet-2415	236	6	from	from	ADP
admet-2415	236	7	that	that	PRON
admet-2415	236	8	in	in	ADP
admet-2415	236	9	mice	mouse	NOUN
admet-2415	236	10	.	.	PUNCT
admet-2415	237	1	the	the	DET
admet-2415	237	2	partition	partition	NOUN
admet-2415	237	3	coefficients	coefficient	NOUN
admet-2415	237	4	of	of	ADP
admet-2415	237	5	each	each	DET
admet-2415	237	6	organ	organ	NOUN
admet-2415	237	7	and	and	CCONJ
admet-2415	237	8	tumor	tumor	NOUN
admet-2415	237	9	have	have	VERB
admet-2415	237	10	the	the	DET
admet-2415	237	11	most	most	ADV
admet-2415	237	12	relevant	relevant	ADJ
admet-2415	237	13	impact	impact	NOUN
admet-2415	237	14	on	on	ADP
admet-2415	237	15	drug	drug	NOUN
admet-2415	237	16	accumulation	accumulation	NOUN
admet-2415	237	17	.	.	PUNCT
admet-2415	238	1	on	on	ADP
admet-2415	238	2	the	the	DET
admet-2415	238	3	other	other	ADJ
admet-2415	238	4	hand	hand	NOUN
admet-2415	238	5	,	,	PUNCT
admet-2415	238	6	the	the	DET
admet-2415	238	7	hepatic	hepatic	ADJ
admet-2415	238	8	clearance	clearance	NOUN
admet-2415	238	9	is	be	AUX
admet-2415	238	10	not	not	PART
admet-2415	238	11	significant	significant	ADJ
admet-2415	238	12	.	.	PUNCT
admet-2415	239	1	the	the	DET
admet-2415	239	2	liver	liver	NOUN
admet-2415	239	3	partition	partition	NOUN
admet-2415	239	4	coefficient	coefficient	NOUN
admet-2415	239	5	is	be	AUX
admet-2415	239	6	the	the	DET
admet-2415	239	7	most	most	ADV
admet-2415	239	8	influential	influential	ADJ
admet-2415	239	9	parameter	parameter	NOUN
admet-2415	239	10	for	for	ADP
admet-2415	239	11	blood	blood	NOUN
admet-2415	239	12	plasma	plasma	NOUN
admet-2415	239	13	instead	instead	ADV
admet-2415	239	14	of	of	ADP
admet-2415	239	15	clearance	clearance	NOUN
admet-2415	239	16	.	.	PUNCT
admet-2415	240	1	ostensibly	ostensibly	ADV
admet-2415	240	2	,	,	PUNCT
admet-2415	240	3	the	the	DET
admet-2415	240	4	sensitivity	sensitivity	NOUN
admet-2415	240	5	data	datum	NOUN
admet-2415	240	6	indicate	indicate	VERB
admet-2415	240	7	that	that	SCONJ
admet-2415	240	8	instead	instead	ADV
admet-2415	240	9	of	of	ADP
admet-2415	240	10	systemic	systemic	ADJ
admet-2415	240	11	elimination	elimination	NOUN
admet-2415	240	12	,	,	PUNCT
admet-2415	240	13	drug	drug	NOUN
admet-2415	240	14	distribution	distribution	NOUN
admet-2415	240	15	to	to	ADP
admet-2415	240	16	organs	organ	NOUN
admet-2415	240	17	contributes	contribute	VERB
admet-2415	240	18	the	the	DET
admet-2415	240	19	most	most	ADJ
admet-2415	240	20	to	to	ADP
admet-2415	240	21	drug	drug	NOUN
admet-2415	240	22	disposition	disposition	NOUN
admet-2415	240	23	.	.	PUNCT
admet-2415	241	1	the	the	DET
admet-2415	241	2	variations	variation	NOUN
admet-2415	241	3	in	in	ADP
admet-2415	241	4	physiological	physiological	ADJ
admet-2415	241	5	and	and	CCONJ
admet-2415	241	6	anatomical	anatomical	ADJ
admet-2415	241	7	conditions	condition	NOUN
admet-2415	241	8	primarily	primarily	ADV
admet-2415	241	9	cause	cause	VERB
admet-2415	241	10	the	the	DET
admet-2415	241	11	difference	difference	NOUN
admet-2415	241	12	in	in	ADP
admet-2415	241	13	biodistribution	biodistribution	NOUN
admet-2415	241	14	between	between	ADP
admet-2415	241	15	mice	mouse	NOUN
admet-2415	241	16	and	and	CCONJ
admet-2415	241	17	humans	human	NOUN
admet-2415	241	18	.	.	PUNCT
admet-2415	242	1	in	in	ADP
admet-2415	242	2	humans	human	NOUN
admet-2415	242	3	,	,	PUNCT
admet-2415	242	4	the	the	DET
admet-2415	242	5	cardiac	cardiac	ADJ
admet-2415	242	6	flow	flow	NOUN
admet-2415	242	7	rate	rate	NOUN
admet-2415	242	8	(	(	PUNCT
admet-2415	242	9	qlu	qlu	NOUN
admet-2415	242	10	)	)	PUNCT
admet-2415	242	11	is	be	AUX
admet-2415	242	12	about	about	ADV
admet-2415	242	13	four	four	NUM
admet-2415	242	14	times	time	NOUN
admet-2415	242	15	greater	great	ADJ
admet-2415	242	16	than	than	ADP
admet-2415	242	17	that	that	PRON
admet-2415	242	18	in	in	ADP
admet-2415	242	19	the	the	DET
admet-2415	242	20	liver	liver	NOUN
admet-2415	242	21	;	;	PUNCT
admet-2415	242	22	the	the	DET
admet-2415	242	23	blood	blood	NOUN
admet-2415	242	24	volume	volume	NOUN
admet-2415	242	25	is	be	AUX
admet-2415	242	26	also	also	ADV
admet-2415	242	27	3	3	NUM
admet-2415	242	28	-	-	SYM
admet-2415	242	29	4	4	NUM
admet-2415	242	30	times	time	NOUN
admet-2415	242	31	higher	high	ADJ
admet-2415	242	32	(	(	PUNCT
admet-2415	242	33	table	table	NOUN
admet-2415	242	34	2	2	NUM
admet-2415	242	35	)	)	PUNCT
admet-2415	242	36	.	.	PUNCT
admet-2415	243	1	in	in	ADP
admet-2415	243	2	mice	mouse	NOUN
admet-2415	243	3	,	,	PUNCT
admet-2415	243	4	however	however	ADV
admet-2415	243	5	,	,	PUNCT
admet-2415	243	6	even	even	ADV
admet-2415	243	7	though	though	SCONJ
admet-2415	243	8	the	the	DET
admet-2415	243	9	liver	liver	NOUN
admet-2415	243	10	blood	blood	NOUN
admet-2415	243	11	flow	flow	NOUN
admet-2415	243	12	rate	rate	NOUN
admet-2415	243	13	is	be	AUX
admet-2415	243	14	about	about	ADV
admet-2415	243	15	four	four	NUM
admet-2415	243	16	times	time	NOUN
admet-2415	243	17	smaller	small	ADJ
admet-2415	243	18	than	than	ADP
admet-2415	243	19	that	that	PRON
admet-2415	243	20	in	in	ADP
admet-2415	243	21	blood	blood	NOUN
admet-2415	243	22	,	,	PUNCT
admet-2415	243	23	the	the	DET
admet-2415	243	24	liver	liver	NOUN
admet-2415	243	25	volume	volume	NOUN
admet-2415	243	26	is	be	AUX
admet-2415	243	27	similar	similar	ADJ
admet-2415	243	28	to	to	ADP
admet-2415	243	29	the	the	DET
admet-2415	243	30	blood	blood	NOUN
admet-2415	243	31	volume	volume	NOUN
admet-2415	243	32	.	.	PUNCT
admet-2415	244	1	given	give	VERB
admet-2415	244	2	the	the	DET
admet-2415	244	3	same	same	ADJ
admet-2415	244	4	drug	drug	NOUN
admet-2415	244	5	partition	partition	NOUN
admet-2415	244	6	coefficients	coefficient	NOUN
admet-2415	244	7	used	use	VERB
admet-2415	244	8	in	in	ADP
admet-2415	244	9	both	both	DET
admet-2415	244	10	mice	mouse	NOUN
admet-2415	244	11	and	and	CCONJ
admet-2415	244	12	human	human	ADJ
admet-2415	244	13	models	model	NOUN
admet-2415	244	14	,	,	PUNCT
admet-2415	244	15	such	such	ADJ
admet-2415	244	16	differences	difference	NOUN
admet-2415	244	17	in	in	ADP
admet-2415	244	18	blood	blood	NOUN
admet-2415	244	19	flow	flow	NOUN
admet-2415	244	20	and	and	CCONJ
admet-2415	244	21	organ	organ	NOUN
admet-2415	244	22	volume	volume	NOUN
admet-2415	244	23	explain	explain	VERB
admet-2415	244	24	drastically	drastically	ADV
admet-2415	244	25	different	different	ADJ
admet-2415	244	26	pk	pk	NOUN
admet-2415	244	27	behaviors	behavior	NOUN
admet-2415	244	28	of	of	ADP
admet-2415	244	29	drug	drug	NOUN
admet-2415	244	30	nanocrystals	nanocrystal	NOUN
admet-2415	244	31	between	between	ADP
admet-2415	244	32	the	the	DET
admet-2415	244	33	two	two	NUM
admet-2415	244	34	biological	biological	ADJ
admet-2415	244	35	systems	system	NOUN
admet-2415	244	36	.	.	PUNCT
admet-2415	245	1	this	this	PRON
admet-2415	245	2	also	also	ADV
admet-2415	245	3	implies	imply	VERB
admet-2415	245	4	that	that	SCONJ
admet-2415	245	5	hepatic	hepatic	ADJ
admet-2415	245	6	uptake	uptake	NOUN
admet-2415	245	7	and	and	CCONJ
admet-2415	245	8	clearance	clearance	NOUN
admet-2415	245	9	are	be	AUX
admet-2415	245	10	more	more	ADV
admet-2415	245	11	significant	significant	ADJ
admet-2415	245	12	in	in	ADP
admet-2415	245	13	rodents	rodent	NOUN
admet-2415	245	14	,	,	PUNCT
admet-2415	245	15	including	include	VERB
admet-2415	245	16	mice	mouse	NOUN
admet-2415	245	17	than	than	ADP
admet-2415	245	18	in	in	ADP
admet-2415	245	19	humans	human	NOUN
admet-2415	245	20	.	.	PUNCT
admet-2415	246	1	from	from	ADP
admet-2415	246	2	an	an	DET
admet-2415	246	3	evolutionary	evolutionary	ADJ
admet-2415	246	4	perspective	perspective	NOUN
admet-2415	246	5	,	,	PUNCT
admet-2415	246	6	it	it	PRON
admet-2415	246	7	could	could	AUX
admet-2415	246	8	make	make	VERB
admet-2415	246	9	more	more	ADJ
admet-2415	246	10	sense	sense	NOUN
admet-2415	246	11	that	that	SCONJ
admet-2415	246	12	humans	human	NOUN
admet-2415	246	13	prepare	prepare	VERB
admet-2415	246	14	and	and	CCONJ
admet-2415	246	15	cook	cook	VERB
admet-2415	246	16	their	their	PRON
admet-2415	246	17	food	food	NOUN
admet-2415	246	18	while	while	SCONJ
admet-2415	246	19	animals	animal	NOUN
admet-2415	246	20	digest	digest	VERB
admet-2415	246	21	raw	raw	ADJ
admet-2415	246	22	organics	organic	NOUN
admet-2415	246	23	.	.	PUNCT
admet-2415	247	1	a	a	DET
admet-2415	247	2	stronger	strong	ADJ
admet-2415	247	3	mps	mp	NOUN
admet-2415	247	4	would	would	AUX
admet-2415	247	5	protect	protect	VERB
admet-2415	247	6	the	the	DET
admet-2415	247	7	body	body	NOUN
admet-2415	247	8	from	from	ADP
admet-2415	247	9	exogenous	exogenous	ADJ
admet-2415	247	10	particles	particle	NOUN
admet-2415	247	11	and	and	CCONJ
admet-2415	247	12	toxins	toxin	NOUN
admet-2415	247	13	absorbed	absorb	VERB
admet-2415	247	14	into	into	ADP
admet-2415	247	15	the	the	DET
admet-2415	247	16	systemic	systemic	ADJ
admet-2415	247	17	circulation	circulation	NOUN
admet-2415	247	18	.	.	PUNCT
admet-2415	248	1	additionally	additionally	ADV
admet-2415	248	2	,	,	PUNCT
admet-2415	248	3	it	it	PRON
admet-2415	248	4	is	be	AUX
admet-2415	248	5	noted	note	VERB
admet-2415	248	6	that	that	SCONJ
admet-2415	248	7	the	the	DET
admet-2415	248	8	scales	scale	NOUN
admet-2415	248	9	are	be	AUX
admet-2415	248	10	significantly	significantly	ADV
admet-2415	248	11	different	different	ADJ
admet-2415	248	12	in	in	ADP
admet-2415	248	13	the	the	DET
admet-2415	248	14	sensitivity	sensitivity	NOUN
admet-2415	248	15	maps	map	NOUN
admet-2415	248	16	between	between	ADP
admet-2415	248	17	mice	mouse	NOUN
admet-2415	248	18	and	and	CCONJ
admet-2415	248	19	humans	human	NOUN
admet-2415	248	20	,	,	PUNCT
admet-2415	248	21	as	as	SCONJ
admet-2415	248	22	shown	show	VERB
admet-2415	248	23	in	in	ADP
admet-2415	248	24	figure	figure	NOUN
admet-2415	248	25	6	6	NUM
admet-2415	248	26	.	.	PUNCT
admet-2415	248	27	figure	figure	VERB
admet-2415	248	28	7	7	NUM
admet-2415	248	29	.	.	NOUN
admet-2415	249	1	sensitivity	sensitivity	NOUN
admet-2415	249	2	analysis	analysis	NOUN
admet-2415	249	3	of	of	ADP
admet-2415	249	4	drug	drug	NOUN
admet-2415	249	5	concentration	concentration	NOUN
admet-2415	249	6	in	in	ADP
admet-2415	249	7	tumor	tumor	NOUN
admet-2415	249	8	with	with	ADP
admet-2415	249	9	respect	respect	NOUN
admet-2415	249	10	to	to	ADP
admet-2415	249	11	pk	pk	NOUN
admet-2415	249	12	parameters	parameter	NOUN
admet-2415	249	13	in	in	ADP
admet-2415	249	14	mice	mouse	NOUN
admet-2415	249	15	.	.	PUNCT
admet-2415	250	1	values	value	NOUN
admet-2415	250	2	are	be	AUX
admet-2415	250	3	sensitivity	sensitivity	NOUN
admet-2415	250	4	values	value	NOUN
admet-2415	250	5	accumulated	accumulate	VERB
admet-2415	250	6	over	over	ADP
admet-2415	250	7	24	24	NUM
admet-2415	250	8	h.	h.	PROPN
admet-2415	250	9	kht	kht	PROPN
admet-2415	250	10	kkd	kkd	PROPN
admet-2415	250	11	kli	kli	PROPN
admet-2415	250	12	klu	klu	PROPN
admet-2415	250	13	ksp	ksp	PROPN
admet-2415	250	14	ktu	ktu	PROPN
admet-2415	250	15	qbl	qbl	PROPN
admet-2415	250	16	qhe	qhe	PROPN
admet-2415	250	17	qht	qht	PROPN
admet-2415	250	18	qkd	qkd	PROPN
admet-2415	250	19	qli	qli	NOUN
admet-2415	251	1	qlu	qlu	VERB
admet-2415	252	1	qkd	qkd	PROPN
admet-2415	252	2	qli	qli	PROPN
admet-2415	252	3	qlu	qlu	NOUN
admet-2415	252	4	clearance	clearance	NOUN
admet-2415	252	5	se	se	X
admet-2415	252	6	n	n	CCONJ
admet-2415	252	7	si	si	X
admet-2415	252	8	ti	ti	X
admet-2415	252	9	vi	vi	NOUN
admet-2415	253	1	ty	ty	INTJ
admet-2415	253	2	o	o	NOUN
admet-2415	253	3	f	f	X
admet-2415	254	1	tu	tu	PROPN
admet-2415	254	2	m	m	NOUN
admet-2415	254	3	o	o	NOUN
admet-2415	254	4	r	r	X
admet-2415	254	5	co	co	NOUN
admet-2415	254	6	n	n	PROPN
admet-2415	254	7	ce	ce	PROPN
admet-2415	254	8	n	n	CCONJ
admet-2415	254	9	tr	tr	VERB
admet-2415	254	10	at	at	ADP
admet-2415	254	11	io	io	PROPN
admet-2415	254	12	n	n	PRON
admet-2415	254	13	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	254	14	s.	s.	PROPN
admet-2415	254	15	lu	lu	PROPN
admet-2415	254	16	et	et	PROPN
admet-2415	254	17	al	al	PROPN
admet-2415	254	18	.	.	PROPN
admet-2415	254	19	admet	admet	PROPN
admet-2415	254	20	&	&	CCONJ
admet-2415	254	21	dmpk	dmpk	PROPN
admet-2415	254	22	12(5	12(5	NUM
admet-2415	254	23	)	)	PUNCT
admet-2415	254	24	(	(	PUNCT
admet-2415	254	25	2024	2024	NUM
admet-2415	254	26	)	)	PUNCT
admet-2415	254	27	705	705	NUM
admet-2415	254	28	-	-	SYM
admet-2415	254	29	719	719	NUM
admet-2415	254	30	716	716	NUM
admet-2415	254	31	a	a	DET
admet-2415	254	32	sensitivity	sensitivity	NOUN
admet-2415	254	33	value	value	NOUN
admet-2415	254	34	is	be	AUX
admet-2415	254	35	much	much	ADV
admet-2415	254	36	higher	high	ADJ
admet-2415	254	37	in	in	ADP
admet-2415	254	38	mice	mouse	NOUN
admet-2415	254	39	than	than	ADP
admet-2415	254	40	humans	human	NOUN
admet-2415	254	41	at	at	ADP
admet-2415	254	42	any	any	DET
admet-2415	254	43	time	time	NOUN
admet-2415	254	44	point	point	NOUN
admet-2415	254	45	of	of	ADP
admet-2415	254	46	simulation	simulation	NOUN
admet-2415	254	47	–	–	PUNCT
admet-2415	254	48	mathematically	mathematically	ADV
admet-2415	254	49	,	,	PUNCT
admet-2415	254	50	a	a	DET
admet-2415	254	51	direct	direct	ADJ
admet-2415	254	52	result	result	NOUN
admet-2415	254	53	of	of	ADP
admet-2415	254	54	the	the	DET
admet-2415	254	55	relative	relative	ADJ
admet-2415	254	56	ratio	ratio	NOUN
admet-2415	254	57	between	between	ADP
admet-2415	254	58	blood	blood	NOUN
admet-2415	254	59	flow	flow	NOUN
admet-2415	254	60	rate	rate	NOUN
admet-2415	254	61	over	over	ADP
admet-2415	254	62	organ	organ	NOUN
admet-2415	254	63	volume	volume	NOUN
admet-2415	254	64	(	(	PUNCT
admet-2415	254	65	or	or	CCONJ
admet-2415	254	66	weight	weight	NOUN
admet-2415	254	67	)	)	PUNCT
admet-2415	254	68	being	be	AUX
admet-2415	254	69	more	more	ADV
admet-2415	254	70	significant	significant	ADJ
admet-2415	254	71	in	in	ADP
admet-2415	254	72	mice	mouse	NOUN
admet-2415	254	73	than	than	ADP
admet-2415	254	74	humans	human	NOUN
admet-2415	254	75	.	.	PUNCT
admet-2415	255	1	figure	figure	VERB
admet-2415	255	2	7	7	NUM
admet-2415	255	3	shows	show	VERB
admet-2415	255	4	the	the	DET
admet-2415	255	5	time	time	NOUN
admet-2415	255	6	-	-	PUNCT
admet-2415	255	7	integrated	integrate	VERB
admet-2415	255	8	sensitivity	sensitivity	NOUN
admet-2415	255	9	values	value	NOUN
admet-2415	255	10	in	in	ADP
admet-2415	255	11	mouse	mouse	NOUN
admet-2415	255	12	tumors	tumor	NOUN
admet-2415	255	13	over	over	ADP
admet-2415	255	14	24	24	NUM
admet-2415	255	15	hours	hour	NOUN
admet-2415	255	16	.	.	PUNCT
admet-2415	256	1	again	again	ADV
admet-2415	256	2	,	,	PUNCT
admet-2415	256	3	it	it	PRON
admet-2415	256	4	is	be	AUX
admet-2415	256	5	shown	show	VERB
admet-2415	256	6	that	that	SCONJ
admet-2415	256	7	the	the	DET
admet-2415	256	8	hepatic	hepatic	ADJ
admet-2415	256	9	clearance	clearance	NOUN
admet-2415	256	10	has	have	VERB
admet-2415	256	11	the	the	DET
admet-2415	256	12	most	most	ADV
admet-2415	256	13	significant	significant	ADJ
admet-2415	256	14	impact	impact	NOUN
admet-2415	256	15	on	on	ADP
admet-2415	256	16	the	the	DET
admet-2415	256	17	drug	drug	NOUN
admet-2415	256	18	accumulation	accumulation	NOUN
admet-2415	256	19	,	,	PUNCT
admet-2415	256	20	four	four	NUM
admet-2415	256	21	times	time	NOUN
admet-2415	256	22	greater	great	ADJ
admet-2415	256	23	than	than	ADP
admet-2415	256	24	the	the	DET
admet-2415	256	25	next	next	ADJ
admet-2415	256	26	contribution	contribution	NOUN
admet-2415	256	27	,	,	PUNCT
admet-2415	256	28	tumor	tumor	NOUN
admet-2415	256	29	blood	blood	NOUN
admet-2415	256	30	flow	flow	NOUN
admet-2415	256	31	rate	rate	NOUN
admet-2415	256	32	,	,	PUNCT
admet-2415	256	33	followed	follow	VERB
admet-2415	256	34	by	by	ADP
admet-2415	256	35	blood	blood	NOUN
admet-2415	256	36	flow	flow	NOUN
admet-2415	256	37	rates	rate	NOUN
admet-2415	256	38	through	through	ADP
admet-2415	256	39	the	the	DET
admet-2415	256	40	hepatic	hepatic	ADJ
admet-2415	256	41	artery	artery	NOUN
admet-2415	256	42	,	,	PUNCT
admet-2415	256	43	spleen	spleen	NOUN
admet-2415	256	44	,	,	PUNCT
admet-2415	256	45	and	and	CCONJ
admet-2415	256	46	liver	liver	NOUN
admet-2415	256	47	.	.	PUNCT
admet-2415	257	1	while	while	SCONJ
admet-2415	257	2	the	the	DET
admet-2415	257	3	blood	blood	NOUN
admet-2415	257	4	flow	flow	NOUN
admet-2415	257	5	rate	rate	NOUN
admet-2415	257	6	and	and	CCONJ
admet-2415	257	7	organ	organ	NOUN
admet-2415	257	8	volume	volume	NOUN
admet-2415	257	9	are	be	AUX
admet-2415	257	10	both	both	ADV
admet-2415	257	11	small	small	ADJ
admet-2415	257	12	in	in	ADP
admet-2415	257	13	the	the	DET
admet-2415	257	14	spleen	spleen	NOUN
admet-2415	257	15	(	(	PUNCT
admet-2415	257	16	table	table	NOUN
admet-2415	257	17	1	1	NUM
admet-2415	257	18	)	)	PUNCT
admet-2415	257	19	,	,	PUNCT
admet-2415	257	20	drug	drug	NOUN
admet-2415	257	21	transport	transport	NOUN
admet-2415	257	22	and	and	CCONJ
admet-2415	257	23	deposition	deposition	NOUN
admet-2415	257	24	in	in	ADP
admet-2415	257	25	the	the	DET
admet-2415	257	26	spleen	spleen	NOUN
admet-2415	257	27	directly	directly	ADV
admet-2415	257	28	contribute	contribute	VERB
admet-2415	257	29	to	to	ADP
admet-2415	257	30	the	the	DET
admet-2415	257	31	drug	drug	NOUN
admet-2415	257	32	concentration	concentration	NOUN
admet-2415	257	33	in	in	ADP
admet-2415	257	34	the	the	DET
admet-2415	257	35	liver	liver	NOUN
admet-2415	257	36	(	(	PUNCT
admet-2415	257	37	eq	eq	NOUN
admet-2415	257	38	.	.	PROPN
admet-2415	257	39	5	5	NUM
admet-2415	257	40	)	)	PUNCT
admet-2415	257	41	.	.	PUNCT
admet-2415	258	1	the	the	DET
admet-2415	258	2	tumor	tumor	NOUN
admet-2415	258	3	partition	partition	NOUN
admet-2415	258	4	coefficient	coefficient	NOUN
admet-2415	258	5	ranks	rank	VERB
admet-2415	258	6	as	as	SCONJ
admet-2415	258	7	the	the	DET
admet-2415	258	8	fourth	fourth	ADJ
admet-2415	258	9	factor	factor	NOUN
admet-2415	258	10	to	to	PART
admet-2415	258	11	alter	alter	VERB
admet-2415	258	12	the	the	DET
admet-2415	258	13	drug	drug	NOUN
admet-2415	258	14	accumulation	accumulation	NOUN
admet-2415	258	15	.	.	PUNCT
admet-2415	259	1	this	this	PRON
admet-2415	259	2	suggests	suggest	VERB
admet-2415	259	3	that	that	SCONJ
admet-2415	259	4	even	even	ADV
admet-2415	259	5	with	with	ADP
admet-2415	259	6	the	the	DET
admet-2415	259	7	so	so	ADV
admet-2415	259	8	-	-	PUNCT
admet-2415	259	9	called	call	VERB
admet-2415	259	10	active	active	ADJ
admet-2415	259	11	targeting	targeting	NOUN
admet-2415	259	12	moieties	moiety	NOUN
admet-2415	259	13	on	on	ADP
admet-2415	259	14	the	the	DET
admet-2415	259	15	surface	surface	NOUN
admet-2415	259	16	of	of	ADP
admet-2415	259	17	nanoparticles	nanoparticle	NOUN
admet-2415	259	18	,	,	PUNCT
admet-2415	259	19	the	the	DET
admet-2415	259	20	formulation	formulation	NOUN
admet-2415	259	21	strategy	strategy	NOUN
admet-2415	259	22	would	would	AUX
admet-2415	259	23	have	have	VERB
admet-2415	259	24	a	a	DET
admet-2415	259	25	minimal	minimal	ADJ
admet-2415	259	26	effect	effect	NOUN
admet-2415	259	27	in	in	ADP
admet-2415	259	28	tumor	tumor	NOUN
admet-2415	259	29	accumulation	accumulation	NOUN
admet-2415	259	30	.	.	PUNCT
admet-2415	260	1	moreover	moreover	ADV
admet-2415	260	2	,	,	PUNCT
admet-2415	260	3	given	give	VERB
admet-2415	260	4	that	that	DET
admet-2415	260	5	tumor	tumor	NOUN
admet-2415	260	6	blood	blood	NOUN
admet-2415	260	7	flow	flow	NOUN
admet-2415	260	8	only	only	ADV
admet-2415	260	9	accounts	account	VERB
admet-2415	260	10	for	for	ADP
admet-2415	260	11	0.2	0.2	NUM
admet-2415	260	12	%	%	NOUN
admet-2415	260	13	of	of	ADP
admet-2415	260	14	the	the	DET
admet-2415	260	15	total	total	ADJ
admet-2415	260	16	blood	blood	NOUN
admet-2415	260	17	output	output	NOUN
admet-2415	260	18	,	,	PUNCT
admet-2415	260	19	any	any	DET
admet-2415	260	20	possible	possible	ADJ
admet-2415	260	21	impact	impact	NOUN
admet-2415	260	22	by	by	ADP
admet-2415	260	23	the	the	DET
admet-2415	260	24	epr	epr	PROPN
admet-2415	260	25	effect	effect	NOUN
admet-2415	260	26	is	be	AUX
admet-2415	260	27	very	very	ADV
admet-2415	260	28	limited	limited	ADJ
admet-2415	260	29	in	in	ADP
admet-2415	260	30	varying	vary	VERB
admet-2415	260	31	the	the	DET
admet-2415	260	32	drug	drug	NOUN
admet-2415	260	33	accumulation	accumulation	NOUN
admet-2415	260	34	in	in	ADP
admet-2415	260	35	the	the	DET
admet-2415	260	36	tumor	tumor	NOUN
admet-2415	260	37	relative	relative	ADJ
admet-2415	260	38	to	to	ADP
admet-2415	260	39	the	the	DET
admet-2415	260	40	total	total	ADJ
admet-2415	260	41	amount	amount	NOUN
admet-2415	260	42	of	of	ADP
admet-2415	260	43	injected	inject	VERB
admet-2415	260	44	dose	dose	NOUN
admet-2415	260	45	.	.	PUNCT
admet-2415	261	1	in	in	ADP
admet-2415	261	2	comparison	comparison	NOUN
admet-2415	261	3	,	,	PUNCT
admet-2415	261	4	blood	blood	NOUN
admet-2415	261	5	flow	flow	NOUN
admet-2415	261	6	in	in	ADP
admet-2415	261	7	the	the	DET
admet-2415	261	8	liver	liver	NOUN
admet-2415	261	9	and	and	CCONJ
admet-2415	261	10	kidney	kidney	NOUN
admet-2415	261	11	accounts	account	VERB
admet-2415	261	12	for	for	ADP
admet-2415	261	13	more	more	ADJ
admet-2415	261	14	than	than	ADP
admet-2415	261	15	22.5	22.5	NUM
admet-2415	261	16	and	and	CCONJ
admet-2415	261	17	16.25	16.25	NUM
admet-2415	261	18	%	%	NOUN
admet-2415	261	19	of	of	ADP
admet-2415	261	20	the	the	DET
admet-2415	261	21	cardiac	cardiac	ADJ
admet-2415	261	22	output	output	NOUN
admet-2415	261	23	,	,	PUNCT
admet-2415	261	24	respectively	respectively	ADV
admet-2415	261	25	(	(	PUNCT
admet-2415	261	26	table	table	NOUN
admet-2415	261	27	1	1	NUM
admet-2415	261	28	)	)	PUNCT
admet-2415	261	29	.	.	PUNCT
admet-2415	262	1	our	our	PRON
admet-2415	262	2	analyses	analysis	NOUN
admet-2415	262	3	suggest	suggest	VERB
admet-2415	262	4	that	that	SCONJ
admet-2415	262	5	in	in	ADP
admet-2415	262	6	mice	mouse	NOUN
admet-2415	262	7	when	when	SCONJ
admet-2415	262	8	given	give	VERB
admet-2415	262	9	intravenously	intravenously	ADV
admet-2415	262	10	,	,	PUNCT
admet-2415	262	11	drug	drug	NOUN
admet-2415	262	12	nanocrystals	nanocrystal	NOUN
admet-2415	262	13	are	be	AUX
admet-2415	262	14	mainly	mainly	ADV
admet-2415	262	15	taken	take	VERB
admet-2415	262	16	up	up	ADP
admet-2415	262	17	by	by	ADP
admet-2415	262	18	the	the	DET
admet-2415	262	19	liver	liver	NOUN
admet-2415	262	20	;	;	PUNCT
admet-2415	262	21	tissue	tissue	NOUN
admet-2415	262	22	distribution	distribution	NOUN
admet-2415	262	23	and	and	CCONJ
admet-2415	262	24	tumor	tumor	NOUN
admet-2415	262	25	accumulation	accumulation	NOUN
admet-2415	262	26	of	of	ADP
admet-2415	262	27	the	the	DET
admet-2415	262	28	drug	drug	NOUN
admet-2415	262	29	are	be	AUX
admet-2415	262	30	subsequently	subsequently	ADV
admet-2415	262	31	determined	determine	VERB
admet-2415	262	32	by	by	ADP
admet-2415	262	33	how	how	SCONJ
admet-2415	262	34	fast	fast	ADJ
admet-2415	262	35	the	the	DET
admet-2415	262	36	drug	drug	NOUN
admet-2415	262	37	is	be	AUX
admet-2415	262	38	eliminated	eliminate	VERB
admet-2415	262	39	from	from	ADP
admet-2415	262	40	the	the	DET
admet-2415	262	41	system	system	NOUN
admet-2415	262	42	.	.	PUNCT
admet-2415	263	1	however	however	ADV
admet-2415	263	2	,	,	PUNCT
admet-2415	263	3	tissue	tissue	NOUN
admet-2415	263	4	distribution	distribution	NOUN
admet-2415	263	5	in	in	ADP
admet-2415	263	6	humans	human	NOUN
admet-2415	263	7	is	be	AUX
admet-2415	263	8	likely	likely	ADV
admet-2415	263	9	driven	drive	VERB
admet-2415	263	10	by	by	ADP
admet-2415	263	11	the	the	DET
admet-2415	263	12	systemic	systemic	ADJ
admet-2415	263	13	circulation	circulation	NOUN
admet-2415	263	14	and	and	CCONJ
admet-2415	263	15	the	the	DET
admet-2415	263	16	organ	organ	NOUN
admet-2415	263	17	affinity	affinity	NOUN
admet-2415	263	18	of	of	ADP
admet-2415	263	19	the	the	DET
admet-2415	263	20	drug	drug	NOUN
admet-2415	263	21	(	(	PUNCT
admet-2415	263	22	delivery	delivery	NOUN
admet-2415	263	23	system	system	NOUN
admet-2415	263	24	)	)	PUNCT
admet-2415	263	25	.	.	PUNCT
admet-2415	264	1	in	in	ADP
admet-2415	264	2	humans	human	NOUN
admet-2415	264	3	,	,	PUNCT
admet-2415	264	4	the	the	DET
admet-2415	264	5	drug	drug	NOUN
admet-2415	264	6	has	have	VERB
admet-2415	264	7	a	a	DET
admet-2415	264	8	greater	great	ADJ
admet-2415	264	9	tendency	tendency	NOUN
admet-2415	264	10	to	to	PART
admet-2415	264	11	be	be	AUX
admet-2415	264	12	deposited	deposit	VERB
admet-2415	264	13	in	in	ADP
admet-2415	264	14	tissues	tissue	NOUN
admet-2415	264	15	and	and	CCONJ
admet-2415	264	16	gradually	gradually	ADV
admet-2415	264	17	released	release	VERB
admet-2415	264	18	back	back	ADV
admet-2415	264	19	into	into	ADP
admet-2415	264	20	the	the	DET
admet-2415	264	21	systemic	systemic	ADJ
admet-2415	264	22	circulation	circulation	NOUN
admet-2415	264	23	(	(	PUNCT
admet-2415	264	24	blood	blood	NOUN
admet-2415	264	25	and	and	CCONJ
admet-2415	264	26	lymph	lymph	NOUN
admet-2415	264	27	)	)	PUNCT
admet-2415	264	28	.	.	PUNCT
admet-2415	265	1	with	with	ADP
admet-2415	265	2	this	this	DET
admet-2415	265	3	regard	regard	NOUN
admet-2415	265	4	,	,	PUNCT
admet-2415	265	5	having	have	VERB
admet-2415	265	6	a	a	DET
admet-2415	265	7	drug	drug	NOUN
admet-2415	265	8	delivery	delivery	NOUN
admet-2415	265	9	system	system	NOUN
admet-2415	265	10	circulating	circulate	VERB
admet-2415	265	11	long	long	ADV
admet-2415	265	12	enough	enough	ADV
admet-2415	265	13	in	in	ADP
admet-2415	265	14	the	the	DET
admet-2415	265	15	blood	blood	NOUN
admet-2415	265	16	(	(	PUNCT
admet-2415	265	17	for	for	ADP
admet-2415	265	18	example	example	NOUN
admet-2415	265	19	,	,	PUNCT
admet-2415	265	20	by	by	ADP
admet-2415	265	21	putting	put	VERB
admet-2415	265	22	biocompatible	biocompatible	ADJ
admet-2415	265	23	surfactants	surfactant	NOUN
admet-2415	265	24	on	on	ADP
admet-2415	265	25	nanoparticle	nanoparticle	NOUN
admet-2415	265	26	surfaces	surface	NOUN
admet-2415	265	27	)	)	PUNCT
admet-2415	265	28	could	could	AUX
admet-2415	265	29	significantly	significantly	ADV
admet-2415	265	30	enhance	enhance	VERB
admet-2415	265	31	tissue	tissue	NOUN
admet-2415	265	32	distribution	distribution	NOUN
admet-2415	265	33	and	and	CCONJ
admet-2415	265	34	tumor	tumor	NOUN
admet-2415	265	35	accumulation	accumulation	NOUN
admet-2415	265	36	in	in	ADP
admet-2415	265	37	mice	mouse	NOUN
admet-2415	265	38	.	.	PUNCT
admet-2415	266	1	conversely	conversely	ADV
admet-2415	266	2	,	,	PUNCT
admet-2415	266	3	having	have	VERB
admet-2415	266	4	such	such	ADJ
admet-2415	266	5	surface	surface	NOUN
admet-2415	266	6	treatment	treatment	NOUN
admet-2415	266	7	or	or	CCONJ
admet-2415	266	8	not	not	PART
admet-2415	266	9	solely	solely	ADV
admet-2415	266	10	to	to	PART
admet-2415	266	11	improve	improve	VERB
admet-2415	266	12	the	the	DET
admet-2415	266	13	blood	blood	NOUN
admet-2415	266	14	circulation	circulation	NOUN
admet-2415	266	15	might	might	AUX
admet-2415	266	16	make	make	VERB
admet-2415	266	17	little	little	ADJ
admet-2415	266	18	distinction	distinction	NOUN
admet-2415	266	19	in	in	ADP
admet-2415	266	20	humans	human	NOUN
admet-2415	266	21	.	.	PUNCT
admet-2415	267	1	although	although	SCONJ
admet-2415	267	2	the	the	DET
admet-2415	267	3	blood	blood	NOUN
admet-2415	267	4	concentration	concentration	NOUN
admet-2415	267	5	of	of	ADP
admet-2415	267	6	ptx	ptx	NOUN
admet-2415	267	7	doubled	double	VERB
admet-2415	267	8	(	(	PUNCT
admet-2415	267	9	figure	figure	NOUN
admet-2415	267	10	4	4	NUM
admet-2415	267	11	)	)	PUNCT
admet-2415	267	12	,	,	PUNCT
admet-2415	267	13	this	this	PRON
admet-2415	267	14	may	may	AUX
admet-2415	267	15	result	result	VERB
admet-2415	267	16	in	in	ADP
admet-2415	267	17	higher	high	ADJ
admet-2415	267	18	tissue	tissue	NOUN
admet-2415	267	19	partitioning	partitioning	NOUN
admet-2415	267	20	of	of	ADP
admet-2415	267	21	the	the	DET
admet-2415	267	22	nc	nc	PROPN
admet-2415	267	23	surface	surface	PROPN
admet-2415	267	24	coating	coating	NOUN
admet-2415	267	25	.	.	PUNCT
admet-2415	268	1	from	from	ADP
admet-2415	268	2	the	the	DET
admet-2415	268	3	systemic	systemic	ADJ
admet-2415	268	4	perspective	perspective	NOUN
admet-2415	268	5	,	,	PUNCT
admet-2415	268	6	the	the	DET
admet-2415	268	7	pk	pk	NOUN
admet-2415	268	8	difference	difference	NOUN
admet-2415	268	9	implies	imply	VERB
admet-2415	268	10	that	that	SCONJ
admet-2415	268	11	treatment	treatment	NOUN
admet-2415	268	12	efficacy	efficacy	NOUN
admet-2415	268	13	and	and	CCONJ
admet-2415	268	14	pk	pk	NOUN
admet-2415	268	15	of	of	ADP
admet-2415	268	16	a	a	DET
admet-2415	268	17	drug	drug	NOUN
admet-2415	268	18	delivery	delivery	NOUN
admet-2415	268	19	system	system	NOUN
admet-2415	268	20	tested	test	VERB
admet-2415	268	21	in	in	ADP
admet-2415	268	22	murine	murine	ADJ
admet-2415	268	23	models	model	NOUN
admet-2415	268	24	may	may	AUX
admet-2415	268	25	not	not	PART
admet-2415	268	26	directly	directly	ADV
admet-2415	268	27	extend	extend	VERB
admet-2415	268	28	to	to	ADP
admet-2415	268	29	humans	human	NOUN
admet-2415	268	30	.	.	PUNCT
admet-2415	269	1	as	as	SCONJ
admet-2415	269	2	indicated	indicate	VERB
admet-2415	269	3	by	by	ADP
admet-2415	269	4	a	a	DET
admet-2415	269	5	literature	literature	NOUN
admet-2415	269	6	report	report	NOUN
admet-2415	269	7	,	,	PUNCT
admet-2415	269	8	two	two	NUM
admet-2415	269	9	different	different	ADJ
admet-2415	269	10	formulations	formulation	NOUN
admet-2415	269	11	of	of	ADP
admet-2415	269	12	ptx	ptx	NOUN
admet-2415	269	13	were	be	AUX
admet-2415	269	14	seen	see	VERB
admet-2415	269	15	to	to	PART
admet-2415	269	16	have	have	VERB
admet-2415	269	17	opposite	opposite	ADJ
admet-2415	269	18	rankings	ranking	NOUN
admet-2415	269	19	in	in	ADP
admet-2415	269	20	anticancer	anticancer	NOUN
admet-2415	269	21	effects	effect	NOUN
admet-2415	269	22	in	in	ADP
admet-2415	269	23	mice	mouse	NOUN
admet-2415	269	24	vs.	vs.	ADP
admet-2415	269	25	human	human	ADJ
admet-2415	269	26	clinical	clinical	ADJ
admet-2415	269	27	trials	trial	NOUN
admet-2415	269	28	[	[	X
admet-2415	269	29	36	36	NUM
admet-2415	269	30	]	]	PUNCT
admet-2415	269	31	.	.	PUNCT
admet-2415	270	1	conclusions	conclusion	NOUN
admet-2415	270	2	in	in	ADP
admet-2415	270	3	this	this	DET
admet-2415	270	4	study	study	NOUN
admet-2415	270	5	,	,	PUNCT
admet-2415	270	6	we	we	PRON
admet-2415	270	7	applied	apply	VERB
admet-2415	270	8	pbpk	pbpk	NOUN
admet-2415	270	9	and	and	CCONJ
admet-2415	270	10	pd	pd	NOUN
admet-2415	270	11	modeling	modeling	NOUN
admet-2415	270	12	to	to	PART
admet-2415	270	13	analyze	analyze	VERB
admet-2415	270	14	animal	animal	NOUN
admet-2415	270	15	test	test	NOUN
admet-2415	270	16	results	result	NOUN
admet-2415	270	17	of	of	ADP
admet-2415	270	18	ptx	ptx	NOUN
admet-2415	270	19	nanocrystals	nanocrystal	NOUN
admet-2415	270	20	.	.	PUNCT
admet-2415	271	1	sensitivity	sensitivity	NOUN
admet-2415	271	2	analyses	analysis	NOUN
admet-2415	271	3	were	be	AUX
admet-2415	271	4	conducted	conduct	VERB
admet-2415	271	5	of	of	ADP
admet-2415	271	6	the	the	DET
admet-2415	271	7	pk	pk	NOUN
admet-2415	271	8	parameters	parameter	NOUN
admet-2415	271	9	derived	derive	VERB
admet-2415	271	10	from	from	ADP
admet-2415	271	11	the	the	DET
admet-2415	271	12	modeling	modeling	NOUN
admet-2415	271	13	study	study	NOUN
admet-2415	271	14	,	,	PUNCT
admet-2415	271	15	and	and	CCONJ
admet-2415	271	16	scaling	scale	VERB
admet-2415	271	17	the	the	DET
admet-2415	271	18	pk	pk	NOUN
admet-2415	271	19	/	/	SYM
admet-2415	271	20	pd	pd	NOUN
admet-2415	271	21	models	model	NOUN
admet-2415	271	22	to	to	ADP
admet-2415	271	23	humans	human	NOUN
admet-2415	271	24	was	be	AUX
admet-2415	271	25	attempted	attempt	VERB
admet-2415	271	26	.	.	PUNCT
admet-2415	272	1	the	the	DET
admet-2415	272	2	modeling	modeling	NOUN
admet-2415	272	3	results	result	NOUN
admet-2415	272	4	shed	shed	VERB
admet-2415	272	5	some	some	DET
admet-2415	272	6	light	light	NOUN
admet-2415	272	7	on	on	ADP
admet-2415	272	8	tumor	tumor	NOUN
admet-2415	272	9	targeting	target	VERB
admet-2415	272	10	by	by	ADP
admet-2415	272	11	nanoparticular	nanoparticular	NOUN
admet-2415	272	12	systems	system	NOUN
admet-2415	272	13	,	,	PUNCT
admet-2415	272	14	especially	especially	ADV
admet-2415	272	15	drug	drug	NOUN
admet-2415	272	16	nanocrystals	nanocrystal	NOUN
admet-2415	272	17	.	.	PUNCT
admet-2415	273	1	because	because	SCONJ
admet-2415	273	2	of	of	ADP
admet-2415	273	3	the	the	DET
admet-2415	273	4	deficient	deficient	ADJ
admet-2415	273	5	blood	blood	NOUN
admet-2415	273	6	supply	supply	NOUN
admet-2415	273	7	to	to	ADP
admet-2415	273	8	tumors	tumor	NOUN
admet-2415	273	9	,	,	PUNCT
admet-2415	273	10	drug	drug	NOUN
admet-2415	273	11	accumulation	accumulation	NOUN
admet-2415	273	12	is	be	AUX
admet-2415	273	13	inherently	inherently	ADV
admet-2415	273	14	limited	limited	ADJ
admet-2415	273	15	.	.	PUNCT
admet-2415	274	1	in	in	ADP
admet-2415	274	2	mice	mice	NOUN
admet-2415	274	3	,	,	PUNCT
admet-2415	274	4	drug	drug	NOUN
admet-2415	274	5	clearance	clearance	NOUN
admet-2415	274	6	of	of	ADP
admet-2415	274	7	nanocrystals	nanocrystal	NOUN
admet-2415	274	8	by	by	ADP
admet-2415	274	9	the	the	DET
admet-2415	274	10	liver	liver	NOUN
admet-2415	274	11	is	be	AUX
admet-2415	274	12	the	the	DET
admet-2415	274	13	most	most	ADV
admet-2415	274	14	critical	critical	ADJ
admet-2415	274	15	factor	factor	NOUN
admet-2415	274	16	in	in	ADP
admet-2415	274	17	determining	determine	VERB
admet-2415	274	18	the	the	DET
admet-2415	274	19	biodistribution	biodistribution	NOUN
admet-2415	274	20	and	and	CCONJ
admet-2415	274	21	pk	pk	NOUN
admet-2415	274	22	in	in	ADP
admet-2415	274	23	the	the	DET
admet-2415	274	24	body	body	NOUN
admet-2415	274	25	.	.	PUNCT
admet-2415	275	1	surface	surface	NOUN
admet-2415	275	2	treatment	treatment	NOUN
admet-2415	275	3	of	of	ADP
admet-2415	275	4	nanoparticles	nanoparticle	NOUN
admet-2415	275	5	to	to	PART
admet-2415	275	6	prolong	prolong	VERB
admet-2415	275	7	their	their	PRON
admet-2415	275	8	blood	blood	NOUN
admet-2415	275	9	circulation	circulation	NOUN
admet-2415	275	10	will	will	AUX
admet-2415	275	11	likely	likely	ADV
admet-2415	275	12	have	have	VERB
admet-2415	275	13	a	a	DET
admet-2415	275	14	positive	positive	ADJ
admet-2415	275	15	effect	effect	NOUN
admet-2415	275	16	on	on	ADP
admet-2415	275	17	mitigating	mitigate	VERB
admet-2415	275	18	the	the	DET
admet-2415	275	19	clearance	clearance	NOUN
admet-2415	275	20	and	and	CCONJ
admet-2415	275	21	enhancing	enhance	VERB
admet-2415	275	22	tumor	tumor	NOUN
admet-2415	275	23	accumulation	accumulation	NOUN
admet-2415	275	24	.	.	PUNCT
admet-2415	276	1	the	the	DET
admet-2415	276	2	impact	impact	NOUN
admet-2415	276	3	of	of	ADP
admet-2415	276	4	leaky	leaky	ADJ
admet-2415	276	5	vasculatures	vasculature	NOUN
admet-2415	276	6	and	and	CCONJ
admet-2415	276	7	deficient	deficient	ADJ
admet-2415	276	8	lymphatic	lymphatic	ADJ
admet-2415	276	9	drainage	drainage	NOUN
admet-2415	276	10	in	in	ADP
admet-2415	276	11	tumors	tumor	NOUN
admet-2415	276	12	(	(	PUNCT
admet-2415	276	13	i.e.	i.e.	X
admet-2415	276	14	,	,	PUNCT
admet-2415	276	15	so	so	ADV
admet-2415	276	16	-	-	PUNCT
admet-2415	276	17	called	call	VERB
admet-2415	276	18	epr	epr	PROPN
admet-2415	276	19	effect	effect	NOUN
admet-2415	276	20	)	)	PUNCT
admet-2415	276	21	on	on	ADP
admet-2415	276	22	drug	drug	NOUN
admet-2415	276	23	deposition	deposition	NOUN
admet-2415	276	24	to	to	ADP
admet-2415	276	25	the	the	DET
admet-2415	276	26	tumor	tumor	NOUN
admet-2415	276	27	,	,	PUNCT
admet-2415	276	28	however	however	ADV
admet-2415	276	29	,	,	PUNCT
admet-2415	276	30	is	be	AUX
admet-2415	276	31	minimal	minimal	ADJ
admet-2415	276	32	.	.	PUNCT
admet-2415	277	1	in	in	ADP
admet-2415	277	2	humans	human	NOUN
admet-2415	277	3	,	,	PUNCT
admet-2415	277	4	it	it	PRON
admet-2415	277	5	is	be	AUX
admet-2415	277	6	the	the	DET
admet-2415	277	7	tissue	tissue	NOUN
admet-2415	277	8	partitioning	partitioning	NOUN
admet-2415	277	9	,	,	PUNCT
admet-2415	277	10	not	not	PART
admet-2415	277	11	the	the	DET
admet-2415	277	12	systemic	systemic	ADJ
admet-2415	277	13	clearance	clearance	NOUN
admet-2415	277	14	,	,	PUNCT
admet-2415	277	15	of	of	ADP
admet-2415	277	16	the	the	DET
admet-2415	277	17	drug	drug	NOUN
admet-2415	277	18	that	that	PRON
admet-2415	277	19	determines	determine	VERB
admet-2415	277	20	drug	drug	NOUN
admet-2415	277	21	deposition	deposition	NOUN
admet-2415	277	22	in	in	ADP
admet-2415	277	23	respective	respective	ADJ
admet-2415	277	24	organs	organ	NOUN
admet-2415	277	25	.	.	PUNCT
admet-2415	278	1	tissue	tissue	NOUN
admet-2415	278	2	partitioning	partitioning	NOUN
admet-2415	278	3	is	be	AUX
admet-2415	278	4	affected	affect	VERB
admet-2415	278	5	by	by	ADP
admet-2415	278	6	the	the	DET
admet-2415	278	7	blood	blood	NOUN
admet-2415	278	8	supply	supply	NOUN
admet-2415	278	9	,	,	PUNCT
admet-2415	278	10	vasculature	vasculature	NOUN
admet-2415	278	11	fenestration	fenestration	NOUN
admet-2415	278	12	,	,	PUNCT
admet-2415	278	13	and	and	CCONJ
admet-2415	278	14	drug	drug	NOUN
admet-2415	278	15	binding	bind	VERB
admet-2415	278	16	with	with	ADP
admet-2415	278	17	extracellular	extracellular	ADJ
admet-2415	278	18	proteins	protein	NOUN
admet-2415	278	19	and	and	CCONJ
admet-2415	278	20	other	other	ADJ
admet-2415	278	21	molecules	molecule	NOUN
admet-2415	278	22	.	.	PUNCT
admet-2415	279	1	consequently	consequently	ADV
admet-2415	279	2	,	,	PUNCT
admet-2415	279	3	surface	surface	NOUN
admet-2415	279	4	treatment	treatment	NOUN
admet-2415	279	5	to	to	PART
admet-2415	279	6	enhance	enhance	VERB
admet-2415	279	7	blood	blood	NOUN
admet-2415	279	8	circulation	circulation	NOUN
admet-2415	279	9	may	may	AUX
admet-2415	279	10	have	have	VERB
admet-2415	279	11	a	a	DET
admet-2415	279	12	limited	limited	ADJ
admet-2415	279	13	effect	effect	NOUN
admet-2415	279	14	on	on	ADP
admet-2415	279	15	tumor	tumor	NOUN
admet-2415	279	16	accumulation	accumulation	NOUN
admet-2415	279	17	in	in	ADP
admet-2415	279	18	humans	human	NOUN
admet-2415	279	19	.	.	PUNCT
admet-2415	280	1	on	on	ADP
admet-2415	280	2	the	the	DET
admet-2415	280	3	other	other	ADJ
admet-2415	280	4	hand	hand	NOUN
admet-2415	280	5	,	,	PUNCT
admet-2415	280	6	leaky	leaky	ADJ
admet-2415	280	7	blood	blood	NOUN
admet-2415	280	8	vessels	vessel	NOUN
admet-2415	280	9	could	could	AUX
admet-2415	280	10	increase	increase	VERB
admet-2415	280	11	drug	drug	NOUN
admet-2415	280	12	deposition	deposition	NOUN
admet-2415	280	13	in	in	ADP
admet-2415	280	14	tumors	tumor	NOUN
admet-2415	280	15	.	.	PUNCT
admet-2415	281	1	all	all	ADV
admet-2415	281	2	in	in	ADV
admet-2415	281	3	all	all	PRON
admet-2415	281	4	,	,	PUNCT
admet-2415	281	5	while	while	SCONJ
admet-2415	281	6	mouse	mouse	NOUN
admet-2415	281	7	models	model	NOUN
admet-2415	281	8	essentially	essentially	ADV
admet-2415	281	9	showed	show	VERB
admet-2415	281	10	liver	liver	NOUN
admet-2415	281	11	uptake	uptake	NOUN
admet-2415	281	12	of	of	ADP
admet-2415	281	13	nc	nc	PROPN
admet-2415	281	14	and	and	CCONJ
admet-2415	281	15	improved	improve	VERB
admet-2415	281	16	tumor	tumor	NOUN
admet-2415	281	17	targeting	targeting	NOUN
admet-2415	281	18	of	of	ADP
admet-2415	281	19	nc	nc	PROPN
admet-2415	281	20	through	through	ADP
admet-2415	281	21	f68	f68	PROPN
admet-2415	281	22	coating	coating	NOUN
admet-2415	281	23	,	,	PUNCT
admet-2415	281	24	pk	pk	NOUN
admet-2415	281	25	behaviors	behavior	NOUN
admet-2415	281	26	in	in	ADP
admet-2415	281	27	humans	human	NOUN
admet-2415	281	28	of	of	ADP
admet-2415	281	29	this	this	DET
admet-2415	281	30	drug	drug	NOUN
admet-2415	281	31	delivery	delivery	NOUN
admet-2415	281	32	system	system	NOUN
admet-2415	281	33	may	may	AUX
admet-2415	281	34	be	be	AUX
admet-2415	281	35	drastically	drastically	ADV
admet-2415	281	36	different	different	ADJ
admet-2415	281	37	.	.	PUNCT
admet-2415	282	1	admet	admet	PROPN
admet-2415	282	2	&	&	CCONJ
admet-2415	282	3	dmpk	dmpk	PROPN
admet-2415	282	4	12(5	12(5	NUM
admet-2415	282	5	)	)	PUNCT
admet-2415	282	6	(	(	PUNCT
admet-2415	282	7	2024	2024	NUM
admet-2415	282	8	)	)	PUNCT
admet-2415	282	9	705	705	NUM
admet-2415	282	10	-	-	SYM
admet-2415	282	11	719	719	NUM
admet-2415	282	12	drug	drug	NOUN
admet-2415	282	13	delivery	delivery	NOUN
admet-2415	282	14	to	to	ADP
admet-2415	282	15	tumor	tumor	NOUN
admet-2415	282	16	by	by	ADP
admet-2415	282	17	nanoparticles	nanoparticle	NOUN
admet-2415	282	18	doi	doi	NOUN
admet-2415	282	19	:	:	PUNCT
admet-2415	282	20	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	282	21	717	717	NUM
admet-2415	283	1	it	it	PRON
admet-2415	283	2	seems	seem	VERB
admet-2415	283	3	plausible	plausible	ADJ
admet-2415	283	4	that	that	SCONJ
admet-2415	283	5	even	even	ADV
admet-2415	283	6	without	without	ADP
admet-2415	283	7	surface	surface	NOUN
admet-2415	283	8	-	-	PUNCT
admet-2415	283	9	bound	bind	VERB
admet-2415	283	10	polymers	polymer	NOUN
admet-2415	283	11	,	,	PUNCT
admet-2415	283	12	drug	drug	NOUN
admet-2415	283	13	nanocrystals	nanocrystal	NOUN
admet-2415	283	14	could	could	AUX
admet-2415	283	15	still	still	ADV
admet-2415	283	16	have	have	VERB
admet-2415	283	17	satisfactory	satisfactory	ADJ
admet-2415	283	18	antitumor	antitumor	PROPN
admet-2415	283	19	efficacy	efficacy	NOUN
admet-2415	283	20	as	as	SCONJ
admet-2415	283	21	the	the	DET
admet-2415	283	22	drug	drug	NOUN
admet-2415	283	23	may	may	AUX
admet-2415	283	24	be	be	AUX
admet-2415	283	25	available	available	ADJ
admet-2415	283	26	in	in	ADP
admet-2415	283	27	the	the	DET
admet-2415	283	28	circulation	circulation	NOUN
admet-2415	283	29	and	and	CCONJ
admet-2415	283	30	target	target	NOUN
admet-2415	283	31	site	site	NOUN
admet-2415	283	32	from	from	ADP
admet-2415	283	33	those	those	PRON
admet-2415	283	34	deposited	deposit	VERB
admet-2415	283	35	in	in	ADP
admet-2415	283	36	tissues	tissue	NOUN
admet-2415	283	37	and	and	CCONJ
admet-2415	283	38	organs	organ	NOUN
admet-2415	283	39	.	.	PUNCT
admet-2415	284	1	caution	caution	NOUN
admet-2415	284	2	needs	need	VERB
admet-2415	284	3	to	to	PART
admet-2415	284	4	be	be	AUX
admet-2415	284	5	taken	take	VERB
admet-2415	284	6	when	when	SCONJ
admet-2415	284	7	generalizing	generalize	VERB
admet-2415	284	8	these	these	DET
admet-2415	284	9	conclusions	conclusion	NOUN
admet-2415	284	10	.	.	PUNCT
admet-2415	285	1	our	our	PRON
admet-2415	285	2	extrapolation	extrapolation	NOUN
admet-2415	285	3	to	to	ADP
admet-2415	285	4	humans	human	NOUN
admet-2415	285	5	is	be	AUX
admet-2415	285	6	a	a	DET
admet-2415	285	7	mathematical	mathematical	ADJ
admet-2415	285	8	exercise	exercise	NOUN
admet-2415	285	9	based	base	VERB
admet-2415	285	10	on	on	ADP
admet-2415	285	11	human	human	ADJ
admet-2415	285	12	physiological	physiological	ADJ
admet-2415	285	13	parameters	parameter	NOUN
admet-2415	285	14	with	with	ADP
admet-2415	285	15	drug	drug	NOUN
admet-2415	285	16	partitioning	partitioning	NOUN
admet-2415	285	17	to	to	ADP
admet-2415	285	18	each	each	DET
admet-2415	285	19	organ	organ	NOUN
admet-2415	285	20	derived	derive	VERB
admet-2415	285	21	from	from	ADP
admet-2415	285	22	modeling	model	VERB
admet-2415	285	23	experimental	experimental	ADJ
admet-2415	285	24	data	datum	NOUN
admet-2415	285	25	from	from	ADP
admet-2415	285	26	mice	mouse	NOUN
admet-2415	285	27	(	(	PUNCT
admet-2415	285	28	albeit	albeit	SCONJ
admet-2415	285	29	the	the	DET
admet-2415	285	30	dose	dose	NOUN
admet-2415	285	31	and	and	CCONJ
admet-2415	285	32	clearance	clearance	NOUN
admet-2415	285	33	taken	take	VERB
admet-2415	285	34	from	from	ADP
admet-2415	285	35	human	human	ADJ
admet-2415	285	36	trials	trial	NOUN
admet-2415	285	37	)	)	PUNCT
admet-2415	285	38	.	.	PUNCT
admet-2415	286	1	interpretation	interpretation	NOUN
admet-2415	286	2	of	of	ADP
admet-2415	286	3	the	the	DET
admet-2415	286	4	simulation	simulation	NOUN
admet-2415	286	5	data	datum	NOUN
admet-2415	286	6	merely	merely	ADV
admet-2415	286	7	highlights	highlight	VERB
admet-2415	286	8	the	the	DET
admet-2415	286	9	impact	impact	NOUN
admet-2415	286	10	on	on	ADP
admet-2415	286	11	pk	pk	NOUN
admet-2415	286	12	and	and	CCONJ
admet-2415	286	13	tumor	tumor	NOUN
admet-2415	286	14	targeting	target	VERB
admet-2415	286	15	,	,	PUNCT
admet-2415	286	16	resulting	result	VERB
admet-2415	286	17	from	from	ADP
admet-2415	286	18	the	the	DET
admet-2415	286	19	differences	difference	NOUN
admet-2415	286	20	in	in	ADP
admet-2415	286	21	physiology	physiology	NOUN
admet-2415	286	22	between	between	ADP
admet-2415	286	23	mice	mouse	NOUN
admet-2415	286	24	and	and	CCONJ
admet-2415	286	25	humans	human	NOUN
admet-2415	286	26	.	.	PUNCT
admet-2415	287	1	future	future	ADJ
admet-2415	287	2	studies	study	NOUN
admet-2415	287	3	of	of	ADP
admet-2415	287	4	modeling	model	VERB
admet-2415	287	5	clinical	clinical	ADJ
admet-2415	287	6	trial	trial	NOUN
admet-2415	287	7	data	datum	NOUN
admet-2415	287	8	are	be	AUX
admet-2415	287	9	necessary	necessary	ADJ
admet-2415	287	10	.	.	PUNCT
admet-2415	288	1	conflict	conflict	NOUN
admet-2415	288	2	of	of	ADP
admet-2415	288	3	interest	interest	NOUN
admet-2415	288	4	:	:	PUNCT
admet-2415	288	5	none	none	NOUN
admet-2415	288	6	funding	funding	NOUN
admet-2415	288	7	:	:	PUNCT
admet-2415	288	8	the	the	DET
admet-2415	288	9	authors	author	NOUN
admet-2415	288	10	thank	thank	VERB
admet-2415	288	11	the	the	DET
admet-2415	288	12	support	support	NOUN
admet-2415	288	13	for	for	ADP
admet-2415	288	14	this	this	DET
admet-2415	288	15	study	study	NOUN
admet-2415	288	16	from	from	ADP
admet-2415	288	17	the	the	DET
admet-2415	288	18	allen	allen	PROPN
admet-2415	288	19	chao	chao	PROPN
admet-2415	288	20	endowment	endowment	PROPN
admet-2415	288	21	and	and	CCONJ
admet-2415	288	22	the	the	DET
admet-2415	288	23	digital	digital	ADJ
admet-2415	288	24	human	human	ADJ
admet-2415	288	25	project	project	NOUN
admet-2415	288	26	by	by	ADP
admet-2415	288	27	the	the	DET
admet-2415	288	28	weldon	weldon	PROPN
admet-2415	288	29	school	school	NOUN
admet-2415	288	30	of	of	ADP
admet-2415	288	31	biomedical	biomedical	ADJ
admet-2415	288	32	engineering	engineering	NOUN
admet-2415	288	33	at	at	ADP
admet-2415	288	34	purdue	purdue	PROPN
admet-2415	288	35	university	university	NOUN
admet-2415	288	36	.	.	PUNCT
admet-2415	289	1	references	reference	NOUN
admet-2415	289	2	[	[	X
admet-2415	289	3	1	1	X
admet-2415	289	4	]	]	X
admet-2415	289	5	y.s	y.s	PROPN
admet-2415	289	6	.	.	PROPN
admet-2415	289	7	youn	youn	PROPN
admet-2415	289	8	,	,	PUNCT
admet-2415	289	9	y.h	y.h	PROPN
admet-2415	289	10	.	.	PROPN
admet-2415	289	11	bae	bae	PROPN
admet-2415	289	12	.	.	PROPN
admet-2415	289	13	perspectives	perspective	NOUN
admet-2415	289	14	on	on	ADP
admet-2415	289	15	the	the	DET
admet-2415	289	16	past	past	NOUN
admet-2415	289	17	,	,	PUNCT
admet-2415	289	18	present	present	ADJ
admet-2415	289	19	,	,	PUNCT
admet-2415	289	20	and	and	CCONJ
admet-2415	289	21	future	future	NOUN
admet-2415	289	22	of	of	ADP
admet-2415	289	23	cancer	cancer	NOUN
admet-2415	289	24	nanomedicine	nanomedicine	NOUN
admet-2415	289	25	.	.	PUNCT
admet-2415	290	1	advanced	advanced	ADJ
admet-2415	290	2	drug	drug	NOUN
admet-2415	290	3	delivery	delivery	NOUN
admet-2415	290	4	reviews	review	VERB
admet-2415	290	5	130	130	NUM
admet-2415	290	6	(	(	PUNCT
admet-2415	290	7	2018	2018	NUM
admet-2415	290	8	)	)	PUNCT
admet-2415	290	9	3	3	NUM
admet-2415	290	10	-	-	SYM
admet-2415	290	11	11	11	NUM
admet-2415	290	12	.	.	PUNCT
admet-2415	291	1	https://doi.org/10.1016/j.addr.2018.05.008	https://doi.org/10.1016/j.addr.2018.05.008	NOUN
admet-2415	292	1	[	[	X
admet-2415	292	2	2	2	NUM
admet-2415	292	3	]	]	PUNCT
admet-2415	292	4	s.	s.	PROPN
admet-2415	292	5	wilhelm	wilhelm	PROPN
admet-2415	292	6	,	,	PUNCT
admet-2415	292	7	a.j	a.j	PROPN
admet-2415	292	8	.	.	PROPN
admet-2415	292	9	tavares	tavares	PROPN
admet-2415	292	10	,	,	PUNCT
admet-2415	292	11	q.	q.	PROPN
admet-2415	292	12	dai	dai	PROPN
admet-2415	292	13	,	,	PUNCT
admet-2415	292	14	s.	s.	PROPN
admet-2415	292	15	ohta	ohta	PROPN
admet-2415	292	16	,	,	PUNCT
admet-2415	292	17	j.	j.	PROPN
admet-2415	292	18	audet	audet	PROPN
admet-2415	292	19	,	,	PUNCT
admet-2415	292	20	h.f	h.f	PROPN
admet-2415	292	21	.	.	PROPN
admet-2415	292	22	dvorak	dvorak	PROPN
admet-2415	292	23	,	,	PUNCT
admet-2415	292	24	w.c	w.c	PROPN
admet-2415	292	25	.	.	PROPN
admet-2415	292	26	chan	chan	PROPN
admet-2415	292	27	.	.	PUNCT
admet-2415	293	1	analysis	analysis	NOUN
admet-2415	293	2	of	of	ADP
admet-2415	293	3	nanoparticle	nanoparticle	NOUN
admet-2415	293	4	delivery	delivery	NOUN
admet-2415	293	5	to	to	ADP
admet-2415	293	6	tumours	tumours	PROPN
admet-2415	293	7	.	.	PUNCT
admet-2415	294	1	nature	nature	NOUN
admet-2415	294	2	reviews	review	VERB
admet-2415	294	3	materials	material	NOUN
admet-2415	294	4	1	1	NUM
admet-2415	294	5	(	(	PUNCT
admet-2415	294	6	2016	2016	NUM
admet-2415	294	7	)	)	PUNCT
admet-2415	294	8	16014	16014	NUM
admet-2415	294	9	.	.	PUNCT
admet-2415	295	1	https://doi.org/10.1038/natrevmats.2016.14	https://doi.org/10.1038/natrevmats.2016.14	X
admet-2415	296	1	[	[	X
admet-2415	296	2	3	3	NUM
admet-2415	296	3	]	]	X
admet-2415	296	4	h.	h.	PROPN
admet-2415	296	5	maeda	maeda	PROPN
admet-2415	296	6	,	,	PUNCT
admet-2415	296	7	j.	j.	PROPN
admet-2415	296	8	wu	wu	PROPN
admet-2415	296	9	,	,	PUNCT
admet-2415	296	10	t.	t.	PROPN
admet-2415	296	11	sawa	sawa	PROPN
admet-2415	296	12	,	,	PUNCT
admet-2415	296	13	y.	y.	PROPN
admet-2415	296	14	matsumura	matsumura	PROPN
admet-2415	296	15	,	,	PUNCT
admet-2415	296	16	k.	k.	PROPN
admet-2415	296	17	hori	hori	PROPN
admet-2415	296	18	.	.	PUNCT
admet-2415	297	1	tumor	tumor	NOUN
admet-2415	297	2	vascular	vascular	ADJ
admet-2415	297	3	permeability	permeability	NOUN
admet-2415	297	4	and	and	CCONJ
admet-2415	297	5	the	the	DET
admet-2415	297	6	epr	epr	PROPN
admet-2415	297	7	effect	effect	NOUN
admet-2415	297	8	in	in	ADP
admet-2415	297	9	macromolecular	macromolecular	ADJ
admet-2415	297	10	therapeutics	therapeutic	NOUN
admet-2415	297	11	:	:	PUNCT
admet-2415	297	12	a	a	DET
admet-2415	297	13	review	review	NOUN
admet-2415	297	14	.	.	PUNCT
admet-2415	298	1	journal	journal	PROPN
admet-2415	298	2	of	of	ADP
admet-2415	298	3	controlled	control	VERB
admet-2415	298	4	release	release	NOUN
admet-2415	298	5	65	65	NUM
admet-2415	298	6	(	(	PUNCT
admet-2415	298	7	2000	2000	NUM
admet-2415	298	8	)	)	PUNCT
admet-2415	298	9	271	271	NUM
admet-2415	298	10	-	-	SYM
admet-2415	298	11	284	284	NUM
admet-2415	298	12	.	.	PUNCT
admet-2415	299	1	https://doi.org/10.1016/s0168-3659(99)00248-5	https://doi.org/10.1016/s0168-3659(99)00248-5	PROPN
admet-2415	300	1	[	[	X
admet-2415	300	2	4	4	NUM
admet-2415	300	3	]	]	X
admet-2415	300	4	h.	h.	PROPN
admet-2415	300	5	chen	chen	PROPN
admet-2415	300	6	,	,	PUNCT
admet-2415	300	7	w.	w.	PROPN
admet-2415	300	8	zhang	zhang	PROPN
admet-2415	300	9	,	,	PUNCT
admet-2415	300	10	g.	g.	PROPN
admet-2415	300	11	zhu	zhu	PROPN
admet-2415	300	12	,	,	PUNCT
admet-2415	300	13	j.	j.	PROPN
admet-2415	300	14	xie	xie	PROPN
admet-2415	300	15	,	,	PUNCT
admet-2415	300	16	x.	x.	PROPN
admet-2415	300	17	chen	chen	PROPN
admet-2415	300	18	.	.	PUNCT
admet-2415	301	1	rethinking	rethink	VERB
admet-2415	301	2	cancer	cancer	NOUN
admet-2415	301	3	nanotheranostics	nanotheranostic	NOUN
admet-2415	301	4	.	.	PUNCT
admet-2415	302	1	nature	nature	NOUN
admet-2415	302	2	reviews	review	VERB
admet-2415	302	3	materials	material	NOUN
admet-2415	302	4	2	2	NUM
admet-2415	302	5	(	(	PUNCT
admet-2415	302	6	2017	2017	NUM
admet-2415	302	7	)	)	PUNCT
admet-2415	302	8	17024	17024	NUM
admet-2415	302	9	.	.	PUNCT
admet-2415	303	1	https://doi.org/10.1038/natrevmats.2017.24	https://doi.org/10.1038/natrevmats.2017.24	PUNCT
admet-2415	304	1	[	[	X
admet-2415	304	2	5	5	NUM
admet-2415	304	3	]	]	PUNCT
admet-2415	304	4	q.	q.	PROPN
admet-2415	304	5	dai	dai	PROPN
admet-2415	304	6	,	,	PUNCT
admet-2415	304	7	n.	n.	PROPN
admet-2415	304	8	bertleff	bertleff	PROPN
admet-2415	304	9	-	-	PUNCT
admet-2415	304	10	zieschang	zieschang	PROPN
admet-2415	304	11	,	,	PUNCT
admet-2415	304	12	j.a	j.a	PROPN
admet-2415	304	13	.	.	PROPN
admet-2415	304	14	braunger	braunger	PROPN
admet-2415	304	15	,	,	PUNCT
admet-2415	304	16	m.	m.	NOUN
admet-2415	304	17	björnmalm	björnmalm	NOUN
admet-2415	304	18	,	,	PUNCT
admet-2415	304	19	c.	c.	PROPN
admet-2415	304	20	cortez	cortez	PROPN
admet-2415	304	21	-	-	PUNCT
admet-2415	304	22	jugo	jugo	PROPN
admet-2415	304	23	,	,	PUNCT
admet-2415	304	24	f.	f.	PROPN
admet-2415	304	25	caruso	caruso	PROPN
admet-2415	304	26	.	.	PUNCT
admet-2415	305	1	particle	particle	NOUN
admet-2415	305	2	targeting	target	VERB
admet-2415	305	3	in	in	ADP
admet-2415	305	4	complex	complex	ADJ
admet-2415	305	5	biological	biological	ADJ
admet-2415	305	6	media	medium	NOUN
admet-2415	305	7	.	.	PUNCT
admet-2415	306	1	advanced	advanced	ADJ
admet-2415	306	2	healthcare	healthcare	NOUN
admet-2415	306	3	materials	material	NOUN
admet-2415	306	4	7	7	NUM
admet-2415	306	5	(	(	PUNCT
admet-2415	306	6	2018	2018	NUM
admet-2415	306	7	)	)	PUNCT
admet-2415	306	8	1700575	1700575	NUM
admet-2415	306	9	.	.	PUNCT
admet-2415	307	1	https://doi.org/10.1002/adhm.201700575	https://doi.org/10.1002/adhm.201700575	NOUN
admet-2415	308	1	[	[	X
admet-2415	308	2	6	6	NUM
admet-2415	308	3	]	]	X
admet-2415	308	4	s.k	s.k	PROPN
admet-2415	308	5	.	.	PROPN
admet-2415	308	6	golombek	golombek	PROPN
admet-2415	308	7	,	,	PUNCT
admet-2415	308	8	j.-n	j.-n	PROPN
admet-2415	308	9	.	.	PUNCT
admet-2415	309	1	may	may	AUX
admet-2415	309	2	,	,	PUNCT
admet-2415	309	3	b.	b.	PROPN
admet-2415	309	4	theek	theek	PROPN
admet-2415	309	5	,	,	PUNCT
admet-2415	309	6	l.	l.	PROPN
admet-2415	309	7	appold	appold	PROPN
admet-2415	309	8	,	,	PUNCT
admet-2415	309	9	n.	n.	PROPN
admet-2415	309	10	drude	drude	PROPN
admet-2415	309	11	,	,	PUNCT
admet-2415	309	12	f.	f.	PROPN
admet-2415	309	13	kiessling	kiessling	PROPN
admet-2415	309	14	,	,	PUNCT
admet-2415	309	15	t.	t.	PROPN
admet-2415	309	16	lammers	lammers	PROPN
admet-2415	309	17	.	.	PUNCT
admet-2415	310	1	tumor	tumor	NOUN
admet-2415	310	2	targeting	target	VERB
admet-2415	310	3	via	via	ADP
admet-2415	310	4	epr	epr	ADJ
admet-2415	310	5	:	:	PUNCT
admet-2415	310	6	strategies	strategy	NOUN
admet-2415	310	7	to	to	PART
admet-2415	310	8	enhance	enhance	VERB
admet-2415	310	9	patient	patient	ADJ
admet-2415	310	10	responses	response	NOUN
admet-2415	310	11	.	.	PUNCT
admet-2415	311	1	advanced	advanced	ADJ
admet-2415	311	2	drug	drug	NOUN
admet-2415	311	3	delivery	delivery	NOUN
admet-2415	311	4	reviews	review	VERB
admet-2415	311	5	130	130	NUM
admet-2415	311	6	(	(	PUNCT
admet-2415	311	7	2018	2018	NUM
admet-2415	311	8	)	)	PUNCT
admet-2415	311	9	17	17	NUM
admet-2415	311	10	-	-	SYM
admet-2415	311	11	38	38	NUM
admet-2415	311	12	https://doi.org/10.1016/j.addr.2018.07.007	https://doi.org/10.1016/j.addr.2018.07.007	VERB
admet-2415	311	13	.	.	PUNCT
admet-2415	312	1	[	[	X
admet-2415	312	2	7	7	X
admet-2415	312	3	]	]	X
admet-2415	312	4	w.c	w.c	PROPN
admet-2415	312	5	.	.	PROPN
admet-2415	312	6	zamboni	zamboni	PROPN
admet-2415	312	7	,	,	PUNCT
admet-2415	312	8	j.	j.	PROPN
admet-2415	312	9	szebeni	szebeni	PROPN
admet-2415	312	10	,	,	PUNCT
admet-2415	312	11	s.v	s.v	PROPN
admet-2415	312	12	.	.	PROPN
admet-2415	312	13	kozlov	kozlov	PROPN
admet-2415	312	14	,	,	PUNCT
admet-2415	312	15	a.t	a.t	PROPN
admet-2415	312	16	.	.	PROPN
admet-2415	312	17	lucas	lucas	PROPN
admet-2415	312	18	,	,	PUNCT
admet-2415	312	19	j.a	j.a	PROPN
admet-2415	312	20	.	.	PROPN
admet-2415	312	21	piscitelli	piscitelli	PROPN
admet-2415	312	22	,	,	PUNCT
admet-2415	312	23	m.a	m.a	PROPN
admet-2415	312	24	.	.	PROPN
admet-2415	312	25	dobrovolskaia	dobrovolskaia	PROPN
admet-2415	312	26	.	.	PUNCT
admet-2415	313	1	animal	animal	NOUN
admet-2415	313	2	models	model	NOUN
admet-2415	313	3	for	for	ADP
admet-2415	313	4	analysis	analysis	NOUN
admet-2415	313	5	of	of	ADP
admet-2415	313	6	immunological	immunological	ADJ
admet-2415	313	7	responses	response	NOUN
admet-2415	313	8	to	to	ADP
admet-2415	313	9	nanomaterials	nanomaterial	NOUN
admet-2415	313	10	:	:	PUNCT
admet-2415	313	11	challenges	challenge	NOUN
admet-2415	313	12	and	and	CCONJ
admet-2415	313	13	considerations	consideration	NOUN
admet-2415	313	14	.	.	PUNCT
admet-2415	314	1	advanced	advanced	ADJ
admet-2415	314	2	drug	drug	NOUN
admet-2415	314	3	delivery	delivery	NOUN
admet-2415	314	4	reviews	review	VERB
admet-2415	314	5	136	136	NUM
admet-2415	314	6	-	-	SYM
admet-2415	314	7	137	137	NUM
admet-2415	314	8	(	(	PUNCT
admet-2415	314	9	2018	2018	NUM
admet-2415	314	10	)	)	PUNCT
admet-2415	314	11	82	82	NUM
admet-2415	314	12	-	-	SYM
admet-2415	314	13	96	96	NUM
admet-2415	314	14	.	.	PUNCT
admet-2415	315	1	https://doi.org/10.1016/j.addr.2018.09.012	https://doi.org/10.1016/j.addr.2018.09.012	PRON
admet-2415	315	2	[	[	X
admet-2415	315	3	8	8	NUM
admet-2415	315	4	]	]	X
admet-2415	315	5	d.	d.	PROPN
admet-2415	315	6	prosperi	prosperi	PROPN
admet-2415	315	7	,	,	PUNCT
admet-2415	315	8	f.	f.	PROPN
admet-2415	315	9	corsi	corsi	PROPN
admet-2415	315	10	.	.	PUNCT
admet-2415	315	11	is	be	AUX
admet-2415	315	12	bigger	big	ADJ
admet-2415	315	13	still	still	ADV
admet-2415	315	14	better	well	ADV
admet-2415	315	15	?	?	PUNCT
admet-2415	316	1	walking	walk	VERB
admet-2415	316	2	on	on	ADP
admet-2415	316	3	the	the	DET
admet-2415	316	4	trail	trail	NOUN
admet-2415	316	5	of	of	ADP
admet-2415	316	6	cancer	cancer	NOUN
admet-2415	316	7	nanomedicine	nanomedicine	NOUN
admet-2415	316	8	.	.	PUNCT
admet-2415	317	1	119	119	NUM
admet-2415	317	2	(	(	PUNCT
admet-2415	317	3	2017	2017	NUM
admet-2415	317	4	)	)	PUNCT
admet-2415	317	5	149	149	NUM
admet-2415	317	6	-	-	SYM
admet-2415	317	7	152	152	NUM
admet-2415	317	8	.	.	PUNCT
admet-2415	318	1	https://doi.org/10.1016/j.phrs.2017.01.030	https://doi.org/10.1016/j.phrs.2017.01.030	PROPN
admet-2415	319	1	[	[	X
admet-2415	319	2	9	9	NUM
admet-2415	319	3	]	]	X
admet-2415	319	4	y.	y.	PROPN
admet-2415	319	5	lu	lu	PROPN
admet-2415	319	6	,	,	PUNCT
admet-2415	319	7	y.	y.	PROPN
admet-2415	319	8	lv	lv	PROPN
admet-2415	319	9	,	,	PUNCT
admet-2415	319	10	t.	t.	PROPN
admet-2415	319	11	li	li	PROPN
admet-2415	319	12	.	.	PROPN
admet-2415	319	13	hybrid	hybrid	ADJ
admet-2415	319	14	drug	drug	NOUN
admet-2415	319	15	nanocrystals	nanocrystal	NOUN
admet-2415	319	16	.	.	PUNCT
admet-2415	320	1	advanced	advanced	ADJ
admet-2415	320	2	drug	drug	NOUN
admet-2415	320	3	delivery	delivery	NOUN
admet-2415	320	4	reviews	review	VERB
admet-2415	320	5	143	143	NUM
admet-2415	320	6	(	(	PUNCT
admet-2415	320	7	2019	2019	NUM
admet-2415	320	8	)	)	PUNCT
admet-2415	320	9	115	115	NUM
admet-2415	320	10	-	-	SYM
admet-2415	320	11	133	133	NUM
admet-2415	320	12	.	.	PUNCT
admet-2415	321	1	https://doi.org/10.1016/j.addr.2019.06.006	https://doi.org/10.1016/j.addr.2019.06.006	NOUN
admet-2415	321	2	[	[	X
admet-2415	321	3	10	10	NUM
admet-2415	321	4	]	]	X
admet-2415	321	5	c.p	c.p	PROPN
admet-2415	321	6	.	.	PROPN
admet-2415	321	7	hollis	hollis	PROPN
admet-2415	321	8	,	,	PUNCT
admet-2415	321	9	h.l	h.l	PROPN
admet-2415	321	10	.	.	PROPN
admet-2415	321	11	weiss	weiss	PROPN
admet-2415	321	12	,	,	PUNCT
admet-2415	321	13	m.	m.	NOUN
admet-2415	321	14	leggas	leggas	PROPN
admet-2415	321	15	,	,	PUNCT
admet-2415	321	16	b.m	b.m	PROPN
admet-2415	321	17	.	.	PROPN
admet-2415	321	18	evers	ever	NOUN
admet-2415	321	19	,	,	PUNCT
admet-2415	321	20	r.a	r.a	PROPN
admet-2415	321	21	.	.	PROPN
admet-2415	321	22	gemeinhart	gemeinhart	PROPN
admet-2415	321	23	,	,	PUNCT
admet-2415	321	24	t.	t.	PROPN
admet-2415	321	25	li	li	PROPN
admet-2415	321	26	.	.	PROPN
admet-2415	321	27	biodistribution	biodistribution	NOUN
admet-2415	321	28	and	and	CCONJ
admet-2415	321	29	bioimaging	bioimaging	NOUN
admet-2415	321	30	studies	study	NOUN
admet-2415	321	31	of	of	ADP
admet-2415	321	32	hybrid	hybrid	ADJ
admet-2415	321	33	paclitaxel	paclitaxel	ADJ
admet-2415	321	34	nanocrystals	nanocrystal	NOUN
admet-2415	321	35	:	:	PUNCT
admet-2415	321	36	lessons	lesson	NOUN
admet-2415	321	37	learned	learn	VERB
admet-2415	321	38	of	of	ADP
admet-2415	321	39	the	the	DET
admet-2415	321	40	epr	epr	PROPN
admet-2415	321	41	effect	effect	NOUN
admet-2415	321	42	and	and	CCONJ
admet-2415	321	43	image	image	NOUN
admet-2415	321	44	-	-	PUNCT
admet-2415	321	45	guided	guide	VERB
admet-2415	321	46	drug	drug	NOUN
admet-2415	321	47	delivery	delivery	NOUN
admet-2415	321	48	.	.	PUNCT
admet-2415	322	1	journal	journal	PROPN
admet-2415	322	2	of	of	ADP
admet-2415	322	3	controlled	control	VERB
admet-2415	322	4	release	release	NOUN
admet-2415	322	5	172	172	NUM
admet-2415	322	6	(	(	PUNCT
admet-2415	322	7	2013	2013	NUM
admet-2415	322	8	)	)	PUNCT
admet-2415	322	9	12	12	NUM
admet-2415	322	10	-	-	SYM
admet-2415	322	11	21	21	NUM
admet-2415	322	12	.	.	PUNCT
admet-2415	323	1	https://doi.org/10.1016/j.jconrel.2013.06.039	https://doi.org/10.1016/j.jconrel.2013.06.039	NOUN
admet-2415	323	2	[	[	X
admet-2415	323	3	11	11	NUM
admet-2415	323	4	]	]	PUNCT
admet-2415	323	5	w.	w.	PROPN
admet-2415	323	6	gao	gao	PROPN
admet-2415	323	7	,	,	PUNCT
admet-2415	323	8	y.	y.	PROPN
admet-2415	323	9	chen	chen	PROPN
admet-2415	323	10	,	,	PUNCT
admet-2415	323	11	d.h	d.h	PROPN
admet-2415	323	12	.	.	PROPN
admet-2415	323	13	thompson	thompson	PROPN
admet-2415	323	14	,	,	PUNCT
admet-2415	323	15	k.	k.	PROPN
admet-2415	323	16	park	park	PROPN
admet-2415	323	17	,	,	PUNCT
admet-2415	323	18	t.	t.	PROPN
admet-2415	323	19	li	li	PROPN
admet-2415	323	20	.	.	PROPN
admet-2415	323	21	impact	impact	NOUN
admet-2415	323	22	of	of	ADP
admet-2415	323	23	surfactant	surfactant	ADJ
admet-2415	323	24	treatment	treatment	NOUN
admet-2415	323	25	of	of	ADP
admet-2415	323	26	paclitaxel	paclitaxel	PROPN
admet-2415	323	27	nanocrystals	nanocrystal	NOUN
admet-2415	323	28	on	on	ADP
admet-2415	323	29	biodistribution	biodistribution	NOUN
admet-2415	323	30	and	and	CCONJ
admet-2415	323	31	tumor	tumor	NOUN
admet-2415	323	32	accumulation	accumulation	NOUN
admet-2415	323	33	in	in	ADP
admet-2415	323	34	tumor	tumor	NOUN
admet-2415	323	35	-	-	PUNCT
admet-2415	323	36	bearing	bear	VERB
admet-2415	323	37	mice	mouse	NOUN
admet-2415	323	38	.	.	PUNCT
admet-2415	324	1	journal	journal	PROPN
admet-2415	324	2	of	of	ADP
admet-2415	324	3	controlled	control	VERB
admet-2415	324	4	release	release	NOUN
admet-2415	324	5	237	237	NUM
admet-2415	324	6	(	(	PUNCT
admet-2415	324	7	2016	2016	NUM
admet-2415	324	8	)	)	PUNCT
admet-2415	324	9	168	168	NUM
admet-2415	324	10	-	-	SYM
admet-2415	324	11	176	176	NUM
admet-2415	324	12	.	.	PUNCT
admet-2415	325	1	https://doi.org/10.1016/j.jconrel.2016.07.015	https://doi.org/10.1016/j.jconrel.2016.07.015	NUM
admet-2415	326	1	[	[	X
admet-2415	326	2	12	12	NUM
admet-2415	326	3	]	]	PUNCT
admet-2415	326	4	r.	r.	PROPN
admet-2415	326	5	zhao	zhao	PROPN
admet-2415	326	6	,	,	PUNCT
admet-2415	326	7	c.p	c.p	PROPN
admet-2415	326	8	.	.	PROPN
admet-2415	326	9	hollis	hollis	PROPN
admet-2415	326	10	,	,	PUNCT
admet-2415	326	11	h.	h.	PROPN
admet-2415	326	12	zhang	zhang	PROPN
admet-2415	326	13	,	,	PUNCT
admet-2415	326	14	l.	l.	PROPN
admet-2415	326	15	sun	sun	PROPN
admet-2415	326	16	,	,	PUNCT
admet-2415	326	17	r.a	r.a	PROPN
admet-2415	326	18	.	.	PROPN
admet-2415	326	19	gemeinhart	gemeinhart	PROPN
admet-2415	326	20	,	,	PUNCT
admet-2415	326	21	t.	t.	PROPN
admet-2415	326	22	li	li	PROPN
admet-2415	326	23	.	.	PROPN
admet-2415	326	24	hybrid	hybrid	ADJ
admet-2415	326	25	nanocrystals	nanocrystal	NOUN
admet-2415	326	26	:	:	PUNCT
admet-2415	326	27	achieving	achieve	VERB
admet-2415	326	28	concurrent	concurrent	ADJ
admet-2415	326	29	therapeutic	therapeutic	ADJ
admet-2415	326	30	and	and	CCONJ
admet-2415	326	31	bioimaging	bioimaging	NOUN
admet-2415	326	32	functionalities	functionality	NOUN
admet-2415	326	33	toward	toward	ADP
admet-2415	326	34	solid	solid	ADJ
admet-2415	326	35	tumors	tumor	NOUN
admet-2415	326	36	.	.	PUNCT
admet-2415	327	1	molecular	molecular	ADJ
admet-2415	327	2	pharmaceutics	pharmaceutic	NOUN
admet-2415	327	3	8	8	NUM
admet-2415	327	4	(	(	PUNCT
admet-2415	327	5	2011	2011	NUM
admet-2415	327	6	)	)	PUNCT
admet-2415	327	7	1985	1985	NUM
admet-2415	327	8	-	-	SYM
admet-2415	327	9	1991	1991	NUM
admet-2415	327	10	.	.	PUNCT
admet-2415	328	1	https://doi.org/10.1021/mp200154k	https://doi.org/10.1021/mp200154k	PROPN
admet-2415	328	2	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	328	3	https://doi.org/10.1016/j.addr.2018.05.008	https://doi.org/10.1016/j.addr.2018.05.008	NOUN
admet-2415	328	4	https://doi.org/10.1038/natrevmats.2016.14	https://doi.org/10.1038/natrevmats.2016.14	PRON
admet-2415	328	5	https://doi.org/10.1016/s0168-3659(99)00248-5	https://doi.org/10.1016/s0168-3659(99)00248-5	PROPN
admet-2415	328	6	https://doi.org/10.1038/natrevmats.2017.24	https://doi.org/10.1038/natrevmats.2017.24	PROPN
admet-2415	328	7	https://doi.org/10.1002/adhm.201700575	https://doi.org/10.1002/adhm.201700575	PROPN
admet-2415	328	8	https://doi.org/10.1016/j.addr.2018.07.007	https://doi.org/10.1016/j.addr.2018.07.007	VERB
admet-2415	328	9	https://doi.org/10.1016/j.addr.2018.07.007	https://doi.org/10.1016/j.addr.2018.07.007	VERB
admet-2415	328	10	https://doi.org/10.1016/j.addr.2018.09.012	https://doi.org/10.1016/j.addr.2018.09.012	DET
admet-2415	328	11	https://doi.org/10.1016/j.phrs.2017.01.030	https://doi.org/10.1016/j.phrs.2017.01.030	NOUN
admet-2415	328	12	https://doi.org/10.1016/j.addr.2019.06.006	https://doi.org/10.1016/j.addr.2019.06.006	NOUN
admet-2415	328	13	https://doi.org/10.1016/j.jconrel.2013.06.039	https://doi.org/10.1016/j.jconrel.2013.06.039	NOUN
admet-2415	328	14	https://doi.org/10.1016/j.jconrel.2016.07.015	https://doi.org/10.1016/j.jconrel.2016.07.015	NUM
admet-2415	328	15	https://doi.org/10.1021/mp200154k	https://doi.org/10.1021/mp200154k	VERB
admet-2415	328	16	s.	s.	PROPN
admet-2415	328	17	lu	lu	PROPN
admet-2415	328	18	et	et	PROPN
admet-2415	328	19	al	al	PROPN
admet-2415	328	20	.	.	PROPN
admet-2415	328	21	admet	admet	PROPN
admet-2415	328	22	&	&	CCONJ
admet-2415	328	23	dmpk	dmpk	PROPN
admet-2415	328	24	12(5	12(5	NUM
admet-2415	328	25	)	)	PUNCT
admet-2415	328	26	(	(	PUNCT
admet-2415	328	27	2024	2024	NUM
admet-2415	328	28	)	)	PUNCT
admet-2415	328	29	705	705	NUM
admet-2415	328	30	-	-	SYM
admet-2415	328	31	719	719	NUM
admet-2415	328	32	718	718	NUM
admet-2415	329	1	[	[	PUNCT
admet-2415	329	2	13	13	NUM
admet-2415	329	3	]	]	X
admet-2415	329	4	c.p	c.p	PROPN
admet-2415	329	5	.	.	PROPN
admet-2415	329	6	hollis	hollis	PROPN
admet-2415	329	7	,	,	PUNCT
admet-2415	329	8	t.	t.	PROPN
admet-2415	329	9	li	li	PROPN
admet-2415	329	10	.	.	PROPN
admet-2415	329	11	nanocrystals	nanocrystal	NOUN
admet-2415	329	12	production	production	NOUN
admet-2415	329	13	,	,	PUNCT
admet-2415	329	14	characterization	characterization	NOUN
admet-2415	329	15	,	,	PUNCT
admet-2415	329	16	and	and	CCONJ
admet-2415	329	17	application	application	NOUN
admet-2415	329	18	for	for	ADP
admet-2415	329	19	cancer	cancer	NOUN
admet-2415	329	20	therapy	therapy	NOUN
admet-2415	329	21	.	.	PUNCT
admet-2415	330	1	pharmaceutical	pharmaceutical	ADJ
admet-2415	330	2	sciences	sciences	PROPN
admet-2415	330	3	encyclopedia	encyclopedia	NOUN
admet-2415	330	4	:	:	PUNCT
admet-2415	330	5	drug	drug	NOUN
admet-2415	330	6	discovery	discovery	NOUN
admet-2415	330	7	,	,	PUNCT
admet-2415	330	8	development	development	NOUN
admet-2415	330	9	,	,	PUNCT
admet-2415	330	10	and	and	CCONJ
admet-2415	330	11	manufacturing	manufacturing	NOUN
admet-2415	330	12	(	(	PUNCT
admet-2415	330	13	2010	2010	NUM
admet-2415	330	14	)	)	PUNCT
admet-2415	330	15	126	126	NUM
admet-2415	330	16	.	.	PUNCT
admet-2415	331	1	https://doi.org/10.1002/9780470571224.pse495	https://doi.org/10.1002/9780470571224.pse495	PROPN
admet-2415	332	1	[	[	X
admet-2415	332	2	14	14	NUM
admet-2415	332	3	]	]	X
admet-2415	332	4	y.	y.	PROPN
admet-2415	332	5	lu	lu	PROPN
admet-2415	332	6	,	,	PUNCT
admet-2415	332	7	y.	y.	PROPN
admet-2415	332	8	chen	chen	PROPN
admet-2415	332	9	,	,	PUNCT
admet-2415	332	10	r.a	r.a	PROPN
admet-2415	332	11	.	.	PROPN
admet-2415	332	12	gemeinhart	gemeinhart	PROPN
admet-2415	332	13	,	,	PUNCT
admet-2415	332	14	w.	w.	PROPN
admet-2415	332	15	wu	wu	PROPN
admet-2415	332	16	,	,	PUNCT
admet-2415	332	17	t.	t.	PROPN
admet-2415	332	18	li	li	AUX
admet-2415	332	19	.	.	PUNCT
admet-2415	332	20	developing	develop	VERB
admet-2415	332	21	nanocrystals	nanocrystal	NOUN
admet-2415	332	22	for	for	ADP
admet-2415	332	23	cancer	cancer	NOUN
admet-2415	332	24	treatment	treatment	NOUN
admet-2415	332	25	.	.	PUNCT
admet-2415	333	1	nanomedicine	nanomedicine	NOUN
admet-2415	333	2	10	10	NUM
admet-2415	333	3	(	(	PUNCT
admet-2415	333	4	2015	2015	NUM
admet-2415	333	5	)	)	PUNCT
admet-2415	333	6	2537	2537	NUM
admet-2415	333	7	-	-	SYM
admet-2415	333	8	2552	2552	NUM
admet-2415	333	9	.	.	PUNCT
admet-2415	334	1	https://doi.org/10.2217/nnm.15.73	https://doi.org/10.2217/nnm.15.73	PRON
admet-2415	335	1	[	[	X
admet-2415	335	2	15	15	NUM
admet-2415	335	3	]	]	X
admet-2415	335	4	y.	y.	PROPN
admet-2415	335	5	lu	lu	PROPN
admet-2415	335	6	,	,	PUNCT
admet-2415	335	7	z.-h	z.-h	PROPN
admet-2415	335	8	.	.	PUNCT
admet-2415	336	1	wang	wang	PROPN
admet-2415	336	2	,	,	PUNCT
admet-2415	336	3	t.	t.	PROPN
admet-2415	336	4	li	li	PROPN
admet-2415	336	5	,	,	PUNCT
admet-2415	336	6	h.	h.	PROPN
admet-2415	336	7	mcnally	mcnally	PROPN
admet-2415	336	8	,	,	PUNCT
admet-2415	336	9	k.	k.	PROPN
admet-2415	336	10	park	park	PROPN
admet-2415	336	11	,	,	PUNCT
admet-2415	336	12	m.	m.	NOUN
admet-2415	336	13	sturek	sturek	PROPN
admet-2415	336	14	.	.	PUNCT
admet-2415	337	1	development	development	NOUN
admet-2415	337	2	and	and	CCONJ
admet-2415	337	3	evaluation	evaluation	NOUN
admet-2415	337	4	of	of	ADP
admet-2415	337	5	transferrinstabilized	transferrinstabilize	VERB
admet-2415	337	6	paclitaxel	paclitaxel	ADJ
admet-2415	337	7	nanocrystal	nanocrystal	ADJ
admet-2415	337	8	formulation	formulation	NOUN
admet-2415	337	9	.	.	PUNCT
admet-2415	338	1	journal	journal	PROPN
admet-2415	338	2	of	of	ADP
admet-2415	338	3	controlled	control	VERB
admet-2415	338	4	release	release	NOUN
admet-2415	338	5	176	176	NUM
admet-2415	338	6	(	(	PUNCT
admet-2415	338	7	2014	2014	NUM
admet-2415	338	8	)	)	PUNCT
admet-2415	338	9	76	76	NUM
admet-2415	338	10	-	-	SYM
admet-2415	338	11	85	85	NUM
admet-2415	338	12	.	.	PUNCT
admet-2415	339	1	https://doi.org/10.1016/j.jconrel.2013.12.018	https://doi.org/10.1016/j.jconrel.2013.12.018	NOUN
admet-2415	339	2	[	[	X
admet-2415	339	3	16	16	NUM
admet-2415	339	4	]	]	PUNCT
admet-2415	339	5	k.	k.	PROPN
admet-2415	339	6	hennenfent	hennenfent	PROPN
admet-2415	339	7	,	,	PUNCT
admet-2415	339	8	r.	r.	PROPN
admet-2415	339	9	govindan	govindan	PROPN
admet-2415	339	10	.	.	PUNCT
admet-2415	340	1	novel	novel	ADJ
admet-2415	340	2	formulations	formulation	NOUN
admet-2415	340	3	of	of	ADP
admet-2415	340	4	taxanes	taxane	NOUN
admet-2415	340	5	:	:	PUNCT
admet-2415	340	6	a	a	DET
admet-2415	340	7	review	review	NOUN
admet-2415	340	8	.	.	PUNCT
admet-2415	341	1	old	old	ADJ
admet-2415	341	2	wine	wine	NOUN
admet-2415	341	3	in	in	ADP
admet-2415	341	4	a	a	DET
admet-2415	341	5	new	new	ADJ
admet-2415	341	6	bottle	bottle	NOUN
admet-2415	341	7	?	?	PUNCT
admet-2415	342	1	annals	annal	NOUN
admet-2415	342	2	of	of	ADP
admet-2415	342	3	oncology	oncology	NOUN
admet-2415	342	4	17	17	NUM
admet-2415	342	5	(	(	PUNCT
admet-2415	342	6	2005	2005	NUM
admet-2415	342	7	)	)	PUNCT
admet-2415	342	8	735	735	NUM
admet-2415	342	9	-	-	SYM
admet-2415	342	10	749	749	NUM
admet-2415	342	11	.	.	PUNCT
admet-2415	343	1	https://doi.org/10.1093/annonc/mdj100	https://doi.org/10.1093/annonc/mdj100	PUNCT
admet-2415	344	1	[	[	X
admet-2415	344	2	17	17	NUM
admet-2415	344	3	]	]	X
admet-2415	344	4	h.m	h.m	PROPN
admet-2415	344	5	.	.	PROPN
admet-2415	344	6	jones	jones	PROPN
admet-2415	344	7	,	,	PUNCT
admet-2415	344	8	i.b	i.b	PROPN
admet-2415	344	9	.	.	PROPN
admet-2415	344	10	gardner	gardner	PROPN
admet-2415	344	11	,	,	PUNCT
admet-2415	344	12	k.j	k.j	PROPN
admet-2415	344	13	.	.	PROPN
admet-2415	344	14	watson	watson	PROPN
admet-2415	344	15	.	.	PUNCT
admet-2415	345	1	modelling	modelling	NOUN
admet-2415	345	2	and	and	CCONJ
admet-2415	345	3	pbpk	pbpk	ADJ
admet-2415	345	4	simulation	simulation	NOUN
admet-2415	345	5	in	in	ADP
admet-2415	345	6	drug	drug	NOUN
admet-2415	345	7	discovery	discovery	NOUN
admet-2415	345	8	.	.	PUNCT
admet-2415	346	1	the	the	DET
admet-2415	346	2	aaps	aaps	PROPN
admet-2415	346	3	journal	journal	PROPN
admet-2415	346	4	11	11	NUM
admet-2415	346	5	(	(	PUNCT
admet-2415	346	6	2009	2009	NUM
admet-2415	346	7	)	)	PUNCT
admet-2415	346	8	155	155	NUM
admet-2415	346	9	-	-	SYM
admet-2415	346	10	166	166	NUM
admet-2415	346	11	.	.	PUNCT
admet-2415	347	1	https://doi.org/10.1208/s12248-009-9088-1	https://doi.org/10.1208/s12248-009-9088-1	PROPN
admet-2415	348	1	[	[	X
admet-2415	348	2	18	18	NUM
admet-2415	348	3	]	]	PUNCT
admet-2415	348	4	x.	x.	PROPN
admet-2415	348	5	zhuang	zhuang	PROPN
admet-2415	348	6	,	,	PUNCT
admet-2415	348	7	c.	c.	PROPN
admet-2415	348	8	lu	lu	PROPN
admet-2415	348	9	.	.	PUNCT
admet-2415	349	1	pbpk	pbpk	PROPN
admet-2415	349	2	modeling	modeling	NOUN
admet-2415	349	3	and	and	CCONJ
admet-2415	349	4	simulation	simulation	NOUN
admet-2415	349	5	in	in	ADP
admet-2415	349	6	drug	drug	NOUN
admet-2415	349	7	research	research	NOUN
admet-2415	349	8	and	and	CCONJ
admet-2415	349	9	development	development	NOUN
admet-2415	349	10	.	.	PUNCT
admet-2415	350	1	acta	acta	PROPN
admet-2415	350	2	pharmaceutica	pharmaceutica	PROPN
admet-2415	350	3	sinica	sinica	PROPN
admet-2415	350	4	b	b	PROPN
admet-2415	350	5	6	6	NUM
admet-2415	350	6	(	(	PUNCT
admet-2415	350	7	2016	2016	NUM
admet-2415	350	8	)	)	PUNCT
admet-2415	350	9	430	430	NUM
admet-2415	350	10	-	-	SYM
admet-2415	350	11	440	440	NUM
admet-2415	350	12	.	.	PUNCT
admet-2415	351	1	https://doi.org/10.1016/j.apsb.2016.04.004	https://doi.org/10.1016/j.apsb.2016.04.004	NOUN
admet-2415	351	2	[	[	X
admet-2415	351	3	19	19	NUM
admet-2415	351	4	]	]	X
admet-2415	351	5	f.	f.	PROPN
admet-2415	351	6	bouzom	bouzom	PROPN
admet-2415	351	7	,	,	PUNCT
admet-2415	351	8	k.	k.	PROPN
admet-2415	351	9	ball	ball	PROPN
admet-2415	351	10	,	,	PUNCT
admet-2415	351	11	n.	n.	PROPN
admet-2415	351	12	perdaems	perdaem	NOUN
admet-2415	351	13	,	,	PUNCT
admet-2415	351	14	b.	b.	PROPN
admet-2415	351	15	walther	walther	PROPN
admet-2415	351	16	.	.	PUNCT
admet-2415	352	1	physiologically	physiologically	ADV
admet-2415	352	2	based	base	VERB
admet-2415	352	3	pharmacokinetic	pharmacokinetic	ADJ
admet-2415	352	4	(	(	PUNCT
admet-2415	352	5	pbpk	pbpk	NOUN
admet-2415	352	6	)	)	PUNCT
admet-2415	352	7	modelling	modelling	NOUN
admet-2415	352	8	tools	tool	NOUN
admet-2415	352	9	:	:	PUNCT
admet-2415	352	10	how	how	SCONJ
admet-2415	352	11	to	to	PART
admet-2415	352	12	fit	fit	VERB
admet-2415	352	13	with	with	ADP
admet-2415	352	14	our	our	PRON
admet-2415	352	15	needs	need	NOUN
admet-2415	352	16	?	?	PUNCT
admet-2415	353	1	biopharmaceutics	biopharmaceutics	PROPN
admet-2415	353	2	&	&	CCONJ
admet-2415	353	3	drug	drug	PROPN
admet-2415	353	4	disposition	disposition	NOUN
admet-2415	353	5	33	33	NUM
admet-2415	353	6	(	(	PUNCT
admet-2415	353	7	2012	2012	NUM
admet-2415	353	8	)	)	PUNCT
admet-2415	353	9	55	55	NUM
admet-2415	353	10	-	-	SYM
admet-2415	353	11	71	71	NUM
admet-2415	353	12	.	.	PUNCT
admet-2415	354	1	https://doi.org/10.1002/bdd.1767	https://doi.org/10.1002/bdd.1767	PROPN
admet-2415	354	2	[	[	X
admet-2415	354	3	20	20	NUM
admet-2415	354	4	]	]	PUNCT
admet-2415	354	5	m.	m.	NOUN
admet-2415	354	6	li	li	PROPN
admet-2415	354	7	,	,	PUNCT
admet-2415	354	8	p.	p.	PROPN
admet-2415	354	9	zou	zou	PROPN
admet-2415	354	10	,	,	PUNCT
admet-2415	354	11	k.	k.	PROPN
admet-2415	354	12	tyner	tyner	PROPN
admet-2415	354	13	,	,	PUNCT
admet-2415	354	14	s.	s.	PROPN
admet-2415	354	15	lee	lee	PROPN
admet-2415	354	16	.	.	PROPN
admet-2415	355	1	physiologically	physiologically	ADV
admet-2415	355	2	based	base	VERB
admet-2415	355	3	pharmacokinetic	pharmacokinetic	ADJ
admet-2415	355	4	(	(	PUNCT
admet-2415	355	5	pbpk	pbpk	NOUN
admet-2415	355	6	)	)	PUNCT
admet-2415	355	7	modeling	modeling	NOUN
admet-2415	355	8	of	of	ADP
admet-2415	355	9	pharmaceutical	pharmaceutical	ADJ
admet-2415	355	10	nanoparticles	nanoparticle	NOUN
admet-2415	355	11	.	.	PUNCT
admet-2415	356	1	the	the	DET
admet-2415	356	2	aaps	aaps	PROPN
admet-2415	356	3	journal	journal	PROPN
admet-2415	356	4	19	19	NUM
admet-2415	356	5	(	(	PUNCT
admet-2415	356	6	2017	2017	NUM
admet-2415	356	7	)	)	PUNCT
admet-2415	356	8	26	26	NUM
admet-2415	356	9	-	-	SYM
admet-2415	356	10	42	42	NUM
admet-2415	356	11	.	.	PUNCT
admet-2415	357	1	https://doi.org/10.1208/s12248016-0010-3	https://doi.org/10.1208/s12248016-0010-3	PROPN
admet-2415	358	1	[	[	X
admet-2415	358	2	21	21	NUM
admet-2415	358	3	]	]	X
admet-2415	358	4	e.k	e.k	PROPN
admet-2415	358	5	.	.	PROPN
admet-2415	358	6	rowinsky	rowinsky	PROPN
admet-2415	358	7	,	,	PUNCT
admet-2415	358	8	r.c	r.c	PROPN
admet-2415	358	9	.	.	PROPN
admet-2415	358	10	donehower	donehower	PROPN
admet-2415	358	11	.	.	PUNCT
admet-2415	359	1	paclitaxel	paclitaxel	PROPN
admet-2415	359	2	(	(	PUNCT
admet-2415	359	3	taxol	taxol	PROPN
admet-2415	359	4	)	)	PUNCT
admet-2415	359	5	.	.	PUNCT
admet-2415	360	1	new	new	PROPN
admet-2415	360	2	england	england	PROPN
admet-2415	360	3	journal	journal	PROPN
admet-2415	360	4	of	of	ADP
admet-2415	360	5	medicine	medicine	PROPN
admet-2415	360	6	332	332	NUM
admet-2415	360	7	(	(	PUNCT
admet-2415	360	8	1995	1995	NUM
admet-2415	360	9	)	)	PUNCT
admet-2415	360	10	1004	1004	NUM
admet-2415	360	11	-	-	SYM
admet-2415	360	12	1014	1014	NUM
admet-2415	360	13	.	.	PUNCT
admet-2415	361	1	https://doi.org/10.1056/nejm199504133321507	https://doi.org/10.1056/nejm199504133321507	NOUN
admet-2415	362	1	[	[	X
admet-2415	362	2	22	22	NUM
admet-2415	362	3	]	]	X
admet-2415	362	4	b.	b.	PROPN
admet-2415	362	5	davies	davy	NOUN
admet-2415	362	6	,	,	PUNCT
admet-2415	362	7	t.	t.	PROPN
admet-2415	362	8	morris	morris	PROPN
admet-2415	362	9	.	.	PUNCT
admet-2415	363	1	physiological	physiological	ADJ
admet-2415	363	2	-	-	PUNCT
admet-2415	363	3	parameters	parameter	NOUN
admet-2415	363	4	in	in	ADP
admet-2415	363	5	laboratory	laboratory	NOUN
admet-2415	363	6	-	-	PUNCT
admet-2415	363	7	animals	animal	NOUN
admet-2415	363	8	and	and	CCONJ
admet-2415	363	9	humans	human	NOUN
admet-2415	363	10	.	.	PUNCT
admet-2415	364	1	pharmaceutical	pharmaceutical	ADJ
admet-2415	364	2	research	research	NOUN
admet-2415	364	3	10	10	NUM
admet-2415	364	4	(	(	PUNCT
admet-2415	364	5	1993	1993	NUM
admet-2415	364	6	)	)	PUNCT
admet-2415	364	7	1093	1093	NUM
admet-2415	364	8	-	-	SYM
admet-2415	364	9	1095	1095	NUM
admet-2415	364	10	.	.	PUNCT
admet-2415	365	1	https://doi.org/10.1023/a:1018943613122	https://doi.org/10.1023/a:1018943613122	NOUN
admet-2415	366	1	[	[	X
admet-2415	366	2	23	23	NUM
admet-2415	366	3	]	]	X
admet-2415	366	4	d.k	d.k	PROPN
admet-2415	366	5	.	.	PROPN
admet-2415	366	6	pawaskar	pawaskar	PROPN
admet-2415	366	7	,	,	PUNCT
admet-2415	366	8	r.m	r.m	PROPN
admet-2415	366	9	.	.	PROPN
admet-2415	366	10	straubinger	straubinger	PROPN
admet-2415	366	11	,	,	PUNCT
admet-2415	366	12	g.j	g.j	PROPN
admet-2415	366	13	.	.	PROPN
admet-2415	366	14	fetterly	fetterly	PROPN
admet-2415	366	15	,	,	PUNCT
admet-2415	366	16	b.h	b.h	PROPN
admet-2415	366	17	.	.	PROPN
admet-2415	366	18	hylander	hylander	PROPN
admet-2415	366	19	,	,	PUNCT
admet-2415	366	20	e.a	e.a	PROPN
admet-2415	366	21	.	.	PROPN
admet-2415	366	22	repasky	repasky	PROPN
admet-2415	366	23	,	,	PUNCT
admet-2415	366	24	w.w	w.w	PROPN
admet-2415	366	25	.	.	PROPN
admet-2415	366	26	ma	ma	PROPN
admet-2415	366	27	,	,	PUNCT
admet-2415	366	28	w.j	w.j	PROPN
admet-2415	366	29	.	.	PROPN
admet-2415	366	30	jusko	jusko	PROPN
admet-2415	366	31	.	.	PUNCT
admet-2415	367	1	physiologically	physiologically	ADV
admet-2415	367	2	based	base	VERB
admet-2415	367	3	pharmacokinetic	pharmacokinetic	ADJ
admet-2415	367	4	models	model	NOUN
admet-2415	367	5	for	for	ADP
admet-2415	367	6	everolimus	everolimus	NOUN
admet-2415	367	7	and	and	CCONJ
admet-2415	367	8	sorafenib	sorafenib	NOUN
admet-2415	367	9	in	in	ADP
admet-2415	367	10	mice	mouse	NOUN
admet-2415	367	11	.	.	PUNCT
admet-2415	368	1	cancer	cancer	NOUN
admet-2415	368	2	chemother	chemother	PROPN
admet-2415	368	3	pharmacol	pharmacol	PROPN
admet-2415	368	4	71	71	NUM
admet-2415	368	5	(	(	PUNCT
admet-2415	368	6	2013	2013	NUM
admet-2415	368	7	)	)	PUNCT
admet-2415	368	8	1219	1219	NUM
admet-2415	368	9	-	-	SYM
admet-2415	368	10	1229	1229	NUM
admet-2415	368	11	.	.	PUNCT
admet-2415	369	1	https://doi.org/10.1007/s00280-013-2116-y	https://doi.org/10.1007/s00280-013-2116-y	PROPN
admet-2415	370	1	[	[	X
admet-2415	370	2	24	24	NUM
admet-2415	370	3	]	]	PUNCT
admet-2415	370	4	w.c	w.c	PROPN
admet-2415	370	5	.	.	PROPN
admet-2415	370	6	buijs	buijs	PROPN
admet-2415	370	7	,	,	PUNCT
admet-2415	370	8	j.a	j.a	PROPN
admet-2415	370	9	.	.	PROPN
admet-2415	370	10	siegel	siegel	PROPN
admet-2415	370	11	,	,	PUNCT
admet-2415	370	12	o.c	o.c	PROPN
admet-2415	370	13	.	.	PROPN
admet-2415	370	14	boerman	boerman	PROPN
admet-2415	370	15	,	,	PUNCT
admet-2415	370	16	f.h	f.h	PROPN
admet-2415	370	17	.	.	PROPN
admet-2415	370	18	corstens	corstens	PROPN
admet-2415	370	19	.	.	PUNCT
admet-2415	371	1	absolute	absolute	ADJ
admet-2415	371	2	organ	organ	NOUN
admet-2415	371	3	activity	activity	NOUN
admet-2415	371	4	estimated	estimate	VERB
admet-2415	371	5	by	by	ADP
admet-2415	371	6	five	five	NUM
admet-2415	371	7	different	different	ADJ
admet-2415	371	8	methods	method	NOUN
admet-2415	371	9	of	of	ADP
admet-2415	371	10	background	background	NOUN
admet-2415	371	11	correction	correction	NOUN
admet-2415	371	12	.	.	PUNCT
admet-2415	372	1	journal	journal	NOUN
admet-2415	372	2	of	of	ADP
admet-2415	372	3	nuclear	nuclear	ADJ
admet-2415	372	4	medicine	medicine	NOUN
admet-2415	372	5	39	39	NUM
admet-2415	372	6	(	(	PUNCT
admet-2415	372	7	1998	1998	NUM
admet-2415	372	8	)	)	PUNCT
admet-2415	372	9	2167	2167	NUM
admet-2415	372	10	-	-	SYM
admet-2415	372	11	2172	2172	NUM
admet-2415	372	12	.	.	PUNCT
admet-2415	373	1	[	[	X
admet-2415	373	2	25	25	NUM
admet-2415	373	3	]	]	X
admet-2415	373	4	d.w	d.w	PROPN
admet-2415	373	5	.	.	PROPN
admet-2415	373	6	marquardt	marquardt	PROPN
admet-2415	373	7	.	.	PUNCT
admet-2415	374	1	an	an	DET
admet-2415	374	2	algorithm	algorithm	NOUN
admet-2415	374	3	for	for	ADP
admet-2415	374	4	least	least	ADJ
admet-2415	374	5	-	-	PUNCT
admet-2415	374	6	squares	square	NOUN
admet-2415	374	7	estimation	estimation	NOUN
admet-2415	374	8	of	of	ADP
admet-2415	374	9	nonlinear	nonlinear	ADJ
admet-2415	374	10	parameters	parameter	NOUN
admet-2415	374	11	.	.	PUNCT
admet-2415	375	1	journal	journal	NOUN
admet-2415	375	2	of	of	ADP
admet-2415	375	3	the	the	DET
admet-2415	375	4	society	society	NOUN
admet-2415	375	5	for	for	ADP
admet-2415	375	6	industrial	industrial	ADJ
admet-2415	375	7	and	and	CCONJ
admet-2415	375	8	applied	apply	VERB
admet-2415	375	9	mathematics	mathematic	NOUN
admet-2415	375	10	11	11	NUM
admet-2415	375	11	(	(	PUNCT
admet-2415	375	12	1963	1963	NUM
admet-2415	375	13	)	)	PUNCT
admet-2415	375	14	431	431	NUM
admet-2415	375	15	-	-	SYM
admet-2415	375	16	441	441	NUM
admet-2415	375	17	.	.	PUNCT
admet-2415	376	1	[	[	X
admet-2415	376	2	26	26	NUM
admet-2415	376	3	]	]	X
admet-2415	376	4	j.w	j.w	PROPN
admet-2415	376	5	.	.	PROPN
admet-2415	376	6	fisher	fisher	PROPN
admet-2415	376	7	,	,	PUNCT
admet-2415	376	8	d.	d.	PROPN
admet-2415	376	9	mahle	mahle	PROPN
admet-2415	376	10	,	,	PUNCT
admet-2415	376	11	r.	r.	PROPN
admet-2415	376	12	abbas	abbas	PROPN
admet-2415	376	13	.	.	PUNCT
admet-2415	377	1	a	a	DET
admet-2415	377	2	human	human	ADJ
admet-2415	377	3	physiologically	physiologically	ADV
admet-2415	377	4	based	base	VERB
admet-2415	377	5	pharmacokinetic	pharmacokinetic	ADJ
admet-2415	377	6	model	model	NOUN
admet-2415	377	7	for	for	ADP
admet-2415	377	8	trichloroethylene	trichloroethylene	NOUN
admet-2415	377	9	and	and	CCONJ
admet-2415	377	10	its	its	PRON
admet-2415	377	11	metabolites	metabolite	NOUN
admet-2415	377	12	,	,	PUNCT
admet-2415	377	13	trichloroacetic	trichloroacetic	ADJ
admet-2415	377	14	acid	acid	NOUN
admet-2415	377	15	and	and	CCONJ
admet-2415	377	16	free	free	ADJ
admet-2415	377	17	trichloroethanol	trichloroethanol	NOUN
admet-2415	377	18	.	.	PUNCT
admet-2415	378	1	toxicology	toxicology	NOUN
admet-2415	378	2	and	and	CCONJ
admet-2415	378	3	applied	apply	VERB
admet-2415	378	4	pharmacology	pharmacology	NOUN
admet-2415	378	5	152	152	NUM
admet-2415	378	6	(	(	PUNCT
admet-2415	378	7	1998	1998	NUM
admet-2415	378	8	)	)	PUNCT
admet-2415	378	9	339	339	NUM
admet-2415	378	10	-	-	SYM
admet-2415	378	11	359	359	NUM
admet-2415	378	12	.	.	PUNCT
admet-2415	379	1	https://doi.org/10.1006/taap.1998.8486	https://doi.org/10.1006/taap.1998.8486	PROPN
admet-2415	379	2	[	[	X
admet-2415	379	3	27	27	NUM
admet-2415	379	4	]	]	X
admet-2415	379	5	d.e	d.e	PROPN
admet-2415	379	6	.	.	PROPN
admet-2415	379	7	mager	mager	PROPN
admet-2415	379	8	,	,	PUNCT
admet-2415	379	9	w.j	w.j	PROPN
admet-2415	379	10	.	.	PROPN
admet-2415	379	11	jusko	jusko	PROPN
admet-2415	379	12	.	.	PUNCT
admet-2415	380	1	pharmacodynamic	pharmacodynamic	ADJ
admet-2415	380	2	modeling	modeling	NOUN
admet-2415	380	3	of	of	ADP
admet-2415	380	4	time	time	NOUN
admet-2415	380	5	dependent	dependent	ADJ
admet-2415	380	6	transduction	transduction	NOUN
admet-2415	380	7	systems	system	NOUN
admet-2415	380	8	.	.	PUNCT
admet-2415	381	1	clinical	clinical	ADJ
admet-2415	381	2	pharmacology	pharmacology	NOUN
admet-2415	381	3	&	&	CCONJ
admet-2415	381	4	therapeutics	therapeutic	NOUN
admet-2415	381	5	70	70	NUM
admet-2415	381	6	(	(	PUNCT
admet-2415	381	7	2001	2001	NUM
admet-2415	381	8	)	)	PUNCT
admet-2415	381	9	210	210	NUM
admet-2415	381	10	-	-	SYM
admet-2415	381	11	216	216	NUM
admet-2415	381	12	.	.	PUNCT
admet-2415	382	1	https://doi.org/10.1067/mcp.2001.118244	https://doi.org/10.1067/mcp.2001.118244	NOUN
admet-2415	383	1	[	[	X
admet-2415	383	2	28	28	NUM
admet-2415	383	3	]	]	X
admet-2415	383	4	y.n	y.n	PROPN
admet-2415	383	5	.	.	PROPN
admet-2415	383	6	sun	sun	PROPN
admet-2415	383	7	,	,	PUNCT
admet-2415	383	8	w.j	w.j	PROPN
admet-2415	383	9	.	.	PROPN
admet-2415	383	10	jusko	jusko	PROPN
admet-2415	383	11	.	.	PUNCT
admet-2415	384	1	transit	transit	NOUN
admet-2415	384	2	compartments	compartment	NOUN
admet-2415	384	3	versus	versus	ADP
admet-2415	384	4	gamma	gamma	NOUN
admet-2415	384	5	distribution	distribution	NOUN
admet-2415	384	6	function	function	NOUN
admet-2415	384	7	to	to	PART
admet-2415	384	8	model	model	NOUN
admet-2415	384	9	signal	signal	NOUN
admet-2415	384	10	transduction	transduction	NOUN
admet-2415	384	11	processes	process	NOUN
admet-2415	384	12	in	in	ADP
admet-2415	384	13	pharmacodynamics	pharmacodynamic	NOUN
admet-2415	384	14	.	.	PUNCT
admet-2415	385	1	journal	journal	NOUN
admet-2415	385	2	of	of	ADP
admet-2415	385	3	pharmaceutical	pharmaceutical	PROPN
admet-2415	385	4	sciences	science	NOUN
admet-2415	385	5	87	87	NUM
admet-2415	385	6	(	(	PUNCT
admet-2415	385	7	1998	1998	NUM
admet-2415	385	8	)	)	PUNCT
admet-2415	385	9	732737	732737	NUM
admet-2415	385	10	.	.	PUNCT
admet-2415	386	1	https://doi.org/10.1021/js970414z	https://doi.org/10.1021/js970414z	X
admet-2415	387	1	[	[	X
admet-2415	387	2	29	29	NUM
admet-2415	387	3	]	]	PUNCT
admet-2415	387	4	m.	m.	NOUN
admet-2415	387	5	simeoni	simeoni	NOUN
admet-2415	387	6	,	,	PUNCT
admet-2415	387	7	p.	p.	PROPN
admet-2415	387	8	magni	magni	PROPN
admet-2415	387	9	,	,	PUNCT
admet-2415	387	10	c.	c.	PROPN
admet-2415	387	11	cammia	cammia	PROPN
admet-2415	387	12	,	,	PUNCT
admet-2415	387	13	g.	g.	PROPN
admet-2415	387	14	de	de	X
admet-2415	387	15	nicolao	nicolao	PROPN
admet-2415	387	16	,	,	PUNCT
admet-2415	387	17	v.	v.	PROPN
admet-2415	387	18	croci	croci	PROPN
admet-2415	387	19	,	,	PUNCT
admet-2415	387	20	e.	e.	PROPN
admet-2415	387	21	pesenti	pesenti	PROPN
admet-2415	387	22	,	,	PUNCT
admet-2415	387	23	m.	m.	PROPN
admet-2415	387	24	germani	germani	PROPN
admet-2415	387	25	,	,	PUNCT
admet-2415	387	26	i.	i.	PROPN
admet-2415	387	27	poggesi	poggesi	PROPN
admet-2415	387	28	,	,	PUNCT
admet-2415	387	29	m.	m.	NOUN
admet-2415	387	30	rocchetti	rocchetti	PROPN
admet-2415	387	31	.	.	PUNCT
admet-2415	388	1	predictive	predictive	ADJ
admet-2415	388	2	pharmacokinetic	pharmacokinetic	ADJ
admet-2415	388	3	-	-	PUNCT
admet-2415	388	4	pharmacodynamic	pharmacodynamic	ADJ
admet-2415	388	5	modeling	modeling	NOUN
admet-2415	388	6	of	of	ADP
admet-2415	388	7	tumor	tumor	NOUN
admet-2415	388	8	growth	growth	NOUN
admet-2415	388	9	kinetics	kinetic	NOUN
admet-2415	388	10	in	in	ADP
admet-2415	388	11	xenograft	xenograft	NOUN
admet-2415	388	12	models	model	NOUN
admet-2415	388	13	after	after	ADP
admet-2415	388	14	administration	administration	NOUN
admet-2415	388	15	of	of	ADP
admet-2415	388	16	anticancer	anticancer	NOUN
admet-2415	388	17	agents	agent	NOUN
admet-2415	388	18	.	.	PUNCT
admet-2415	389	1	cancer	cancer	NOUN
admet-2415	389	2	research	research	NOUN
admet-2415	389	3	64	64	NUM
admet-2415	389	4	(	(	PUNCT
admet-2415	389	5	2004	2004	NUM
admet-2415	389	6	)	)	PUNCT
admet-2415	389	7	1094	1094	NUM
admet-2415	389	8	-	-	SYM
admet-2415	389	9	1101	1101	NUM
admet-2415	389	10	.	.	PUNCT
admet-2415	390	1	https://doi.org/10.1158/0008-5472.can-03-2524	https://doi.org/10.1158/0008-5472.can-03-2524	PROPN
admet-2415	391	1	[	[	X
admet-2415	391	2	30	30	NUM
admet-2415	391	3	]	]	X
admet-2415	391	4	a.	a.	NOUN
admet-2415	391	5	brú	brú	PROPN
admet-2415	391	6	,	,	PUNCT
admet-2415	391	7	s.	s.	PROPN
admet-2415	391	8	albertos	albertos	PROPN
admet-2415	391	9	,	,	PUNCT
admet-2415	391	10	j.l	j.l	PROPN
admet-2415	391	11	.	.	PROPN
admet-2415	391	12	subiza	subiza	PROPN
admet-2415	391	13	,	,	PUNCT
admet-2415	391	14	j.l	j.l	PROPN
admet-2415	391	15	.	.	PROPN
admet-2415	391	16	garcía	garcía	PROPN
admet-2415	391	17	-	-	PUNCT
admet-2415	391	18	asenjo	asenjo	PROPN
admet-2415	391	19	,	,	PUNCT
admet-2415	391	20	i.	i.	PROPN
admet-2415	391	21	brú	brú	PROPN
admet-2415	391	22	.	.	PUNCT
admet-2415	392	1	the	the	DET
admet-2415	392	2	universal	universal	ADJ
admet-2415	392	3	dynamics	dynamic	NOUN
admet-2415	392	4	of	of	ADP
admet-2415	392	5	tumor	tumor	NOUN
admet-2415	392	6	growth	growth	NOUN
admet-2415	392	7	.	.	PUNCT
admet-2415	393	1	biophysical	biophysical	ADJ
admet-2415	393	2	journal	journal	NOUN
admet-2415	393	3	85	85	NUM
admet-2415	393	4	(	(	PUNCT
admet-2415	393	5	2003	2003	NUM
admet-2415	393	6	)	)	PUNCT
admet-2415	393	7	2948	2948	NUM
admet-2415	393	8	-	-	SYM
admet-2415	393	9	2961	2961	NUM
admet-2415	393	10	.	.	PUNCT
admet-2415	394	1	https://doi.org/10.1016/s0006-3495(03)74715-8	https://doi.org/10.1016/s0006-3495(03)74715-8	PROPN
admet-2415	395	1	[	[	X
admet-2415	395	2	31	31	NUM
admet-2415	395	3	]	]	PUNCT
admet-2415	395	4	h.	h.	PROPN
admet-2415	395	5	schmidt	schmidt	PROPN
admet-2415	395	6	,	,	PUNCT
admet-2415	395	7	m.	m.	NOUN
admet-2415	395	8	jirstrand	jirstrand	PROPN
admet-2415	395	9	.	.	PUNCT
admet-2415	396	1	systems	system	NOUN
admet-2415	396	2	biology	biology	NOUN
admet-2415	396	3	toolbox	toolbox	NOUN
admet-2415	396	4	for	for	ADP
admet-2415	396	5	matlab	matlab	PROPN
admet-2415	396	6	:	:	PUNCT
admet-2415	396	7	a	a	DET
admet-2415	396	8	computational	computational	ADJ
admet-2415	396	9	platform	platform	NOUN
admet-2415	396	10	for	for	ADP
admet-2415	396	11	research	research	NOUN
admet-2415	396	12	in	in	ADP
admet-2415	396	13	systems	system	NOUN
admet-2415	396	14	biology	biology	NOUN
admet-2415	396	15	.	.	PUNCT
admet-2415	397	1	bioinformatics	bioinformatic	NOUN
admet-2415	397	2	22	22	NUM
admet-2415	397	3	(	(	PUNCT
admet-2415	397	4	2005	2005	NUM
admet-2415	397	5	)	)	PUNCT
admet-2415	397	6	514	514	NUM
admet-2415	397	7	-	-	SYM
admet-2415	397	8	515	515	NUM
admet-2415	397	9	.	.	PUNCT
admet-2415	398	1	https://doi.org/10.1093/bioinformatics/bti799	https://doi.org/10.1093/bioinformatics/bti799	PROPN
admet-2415	398	2	https://doi.org/10.1002/9780470571224.pse495	https://doi.org/10.1002/9780470571224.pse495	PROPN
admet-2415	398	3	https://doi.org/10.2217/nnm.15.73	https://doi.org/10.2217/nnm.15.73	PART
admet-2415	398	4	https://doi.org/10.1016/j.jconrel.2013.12.018	https://doi.org/10.1016/j.jconrel.2013.12.018	PROPN
admet-2415	398	5	https://doi.org/10.1093/annonc/mdj100	https://doi.org/10.1093/annonc/mdj100	X
admet-2415	398	6	https://doi.org/10.1208/s12248-009-9088-1	https://doi.org/10.1208/s12248-009-9088-1	NUM
admet-2415	398	7	https://doi.org/10.1016/j.apsb.2016.04.004	https://doi.org/10.1016/j.apsb.2016.04.004	NOUN
admet-2415	398	8	https://doi.org/10.1002/bdd.1767	https://doi.org/10.1002/bdd.1767	NOUN
admet-2415	398	9	https://doi.org/10.1208/s12248-016-0010-3	https://doi.org/10.1208/s12248-016-0010-3	NUM
admet-2415	398	10	https://doi.org/10.1208/s12248-016-0010-3	https://doi.org/10.1208/s12248-016-0010-3	NUM
admet-2415	398	11	https://doi.org/10.1056/nejm199504133321507	https://doi.org/10.1056/nejm199504133321507	NOUN
admet-2415	398	12	https://doi.org/10.1023/a:1018943613122	https://doi.org/10.1023/a:1018943613122	NOUN
admet-2415	398	13	https://doi.org/10.1007/s00280-013-2116-y	https://doi.org/10.1007/s00280-013-2116-y	PROPN
admet-2415	398	14	https://doi.org/10.1006/taap.1998.8486	https://doi.org/10.1006/taap.1998.8486	PROPN
admet-2415	398	15	https://doi.org/10.1067/mcp.2001.118244	https://doi.org/10.1067/mcp.2001.118244	NOUN
admet-2415	398	16	https://doi.org/10.1021/js970414z	https://doi.org/10.1021/js970414z	PROPN
admet-2415	398	17	https://doi.org/10.1158/0008-5472.can-03-2524	https://doi.org/10.1158/0008-5472.can-03-2524	PROPN
admet-2415	398	18	https://doi.org/10.1016/s0006-3495(03)74715-8	https://doi.org/10.1016/s0006-3495(03)74715-8	PROPN
admet-2415	398	19	https://doi.org/10.1093/bioinformatics/bti799	https://doi.org/10.1093/bioinformatics/bti799	PROPN
admet-2415	398	20	admet	admet	PROPN
admet-2415	398	21	&	&	CCONJ
admet-2415	398	22	dmpk	dmpk	PROPN
admet-2415	398	23	12(5	12(5	NUM
admet-2415	398	24	)	)	PUNCT
admet-2415	398	25	(	(	PUNCT
admet-2415	398	26	2024	2024	NUM
admet-2415	398	27	)	)	PUNCT
admet-2415	398	28	705	705	NUM
admet-2415	398	29	-	-	SYM
admet-2415	398	30	719	719	NUM
admet-2415	398	31	drug	drug	NOUN
admet-2415	398	32	delivery	delivery	NOUN
admet-2415	398	33	to	to	ADP
admet-2415	398	34	tumor	tumor	NOUN
admet-2415	398	35	by	by	ADP
admet-2415	398	36	nanoparticles	nanoparticle	NOUN
admet-2415	398	37	doi	doi	NOUN
admet-2415	398	38	:	:	PUNCT
admet-2415	398	39	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	398	40	719	719	NUM
admet-2415	399	1	[	[	SYM
admet-2415	399	2	32	32	NUM
admet-2415	399	3	]	]	PUNCT
admet-2415	399	4	a.	a.	NOUN
admet-2415	399	5	saltelli	saltelli	PROPN
admet-2415	399	6	,	,	PUNCT
admet-2415	399	7	s.	s.	PROPN
admet-2415	399	8	tarantola	tarantola	PROPN
admet-2415	399	9	,	,	PUNCT
admet-2415	399	10	f.	f.	PROPN
admet-2415	399	11	campolongo	campolongo	PROPN
admet-2415	399	12	,	,	PUNCT
admet-2415	399	13	m.	m.	NOUN
admet-2415	399	14	ratto	ratto	NOUN
admet-2415	399	15	.	.	PUNCT
admet-2415	400	1	sensitivity	sensitivity	NOUN
admet-2415	400	2	analysis	analysis	NOUN
admet-2415	400	3	in	in	ADP
admet-2415	400	4	practice	practice	NOUN
admet-2415	400	5	:	:	PUNCT
admet-2415	400	6	a	a	DET
admet-2415	400	7	guide	guide	NOUN
admet-2415	400	8	to	to	ADP
admet-2415	400	9	assessing	assess	VERB
admet-2415	400	10	scientific	scientific	ADJ
admet-2415	400	11	models	model	NOUN
admet-2415	400	12	.	.	PUNCT
admet-2415	401	1	viley	viley	NOUN
admet-2415	401	2	,	,	PUNCT
admet-2415	401	3	chichester	chichester	PROPN
admet-2415	401	4	,	,	PUNCT
admet-2415	401	5	england	england	PROPN
admet-2415	401	6	(	(	PUNCT
admet-2415	401	7	2004	2004	NUM
admet-2415	401	8	)	)	PUNCT
admet-2415	401	9	.	.	PUNCT
admet-2415	402	1	https://doi.org/10.1002/0470870958	https://doi.org/10.1002/0470870958	X
admet-2415	403	1	[	[	X
admet-2415	403	2	33	33	NUM
admet-2415	403	3	]	]	X
admet-2415	403	4	c.l	c.l	PROPN
admet-2415	403	5	.	.	PROPN
admet-2415	403	6	carter	carter	PROPN
admet-2415	403	7	,	,	PUNCT
admet-2415	403	8	c.	c.	PROPN
admet-2415	403	9	allen	allen	PROPN
admet-2415	403	10	,	,	PUNCT
admet-2415	403	11	d.e	d.e	PROPN
admet-2415	403	12	.	.	PROPN
admet-2415	403	13	henson	henson	PROPN
admet-2415	403	14	.	.	PUNCT
admet-2415	404	1	relation	relation	NOUN
admet-2415	404	2	of	of	ADP
admet-2415	404	3	tumor	tumor	NOUN
admet-2415	404	4	size	size	NOUN
admet-2415	404	5	,	,	PUNCT
admet-2415	404	6	lymph	lymph	NOUN
admet-2415	404	7	node	node	ADJ
admet-2415	404	8	status	status	NOUN
admet-2415	404	9	,	,	PUNCT
admet-2415	404	10	and	and	CCONJ
admet-2415	404	11	survival	survival	NOUN
admet-2415	404	12	in	in	ADP
admet-2415	404	13	24,740	24,740	NUM
admet-2415	404	14	breast	breast	NOUN
admet-2415	404	15	cancer	cancer	NOUN
admet-2415	404	16	cases	case	NOUN
admet-2415	404	17	.	.	PUNCT
admet-2415	405	1	cancer	cancer	NOUN
admet-2415	405	2	63	63	NUM
admet-2415	405	3	(	(	PUNCT
admet-2415	405	4	1989	1989	NUM
admet-2415	405	5	)	)	PUNCT
admet-2415	405	6	181	181	NUM
admet-2415	405	7	-	-	SYM
admet-2415	405	8	187	187	NUM
admet-2415	405	9	.	.	PUNCT
admet-2415	406	1	[	[	X
admet-2415	406	2	34	34	NUM
admet-2415	406	3	]	]	X
admet-2415	406	4	d.s	d.s	PROPN
admet-2415	406	5	.	.	PROPN
admet-2415	406	6	sonnichsen	sonnichsen	PROPN
admet-2415	406	7	,	,	PUNCT
admet-2415	406	8	m.v	m.v	PROPN
admet-2415	406	9	.	.	PROPN
admet-2415	406	10	relling	relle	VERB
admet-2415	406	11	.	.	PUNCT
admet-2415	407	1	clinical	clinical	ADJ
admet-2415	407	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2415	407	3	of	of	ADP
admet-2415	407	4	paclitaxel	paclitaxel	PROPN
admet-2415	407	5	.	.	PUNCT
admet-2415	408	1	clinical	clinical	ADJ
admet-2415	408	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2415	408	3	27	27	NUM
admet-2415	408	4	(	(	PUNCT
admet-2415	408	5	1994	1994	NUM
admet-2415	408	6	)	)	PUNCT
admet-2415	408	7	256	256	NUM
admet-2415	408	8	-	-	SYM
admet-2415	408	9	269	269	NUM
admet-2415	408	10	.	.	PUNCT
admet-2415	409	1	https://doir.org/10.2165/00003088-199427040-00002	https://doir.org/10.2165/00003088-199427040-00002	PROPN
admet-2415	409	2	[	[	X
admet-2415	409	3	35	35	NUM
admet-2415	409	4	]	]	X
admet-2415	409	5	r.k	r.k	PROPN
admet-2415	409	6	.	.	PROPN
admet-2415	409	7	jain	jain	PROPN
admet-2415	409	8	,	,	PUNCT
admet-2415	409	9	k.	k.	PROPN
admet-2415	409	10	ward	ward	PROPN
admet-2415	409	11	-	-	PUNCT
admet-2415	409	12	hartley	hartley	PROPN
admet-2415	409	13	.	.	PUNCT
admet-2415	410	1	tumor	tumor	NOUN
admet-2415	410	2	blood	blood	NOUN
admet-2415	410	3	flow	flow	NOUN
admet-2415	410	4	-	-	PUNCT
admet-2415	410	5	characterization	characterization	NOUN
admet-2415	410	6	,	,	PUNCT
admet-2415	410	7	modifications	modification	NOUN
admet-2415	410	8	,	,	PUNCT
admet-2415	410	9	and	and	CCONJ
admet-2415	410	10	role	role	NOUN
admet-2415	410	11	in	in	ADP
admet-2415	410	12	hyperthermia	hyperthermia	NOUN
admet-2415	410	13	.	.	PUNCT
admet-2415	411	1	ieee	ieee	NOUN
admet-2415	411	2	transactions	transaction	NOUN
admet-2415	411	3	on	on	ADP
admet-2415	411	4	sonics	sonic	NOUN
admet-2415	411	5	and	and	CCONJ
admet-2415	411	6	ultrasonics	ultrasonic	NOUN
admet-2415	411	7	31	31	NUM
admet-2415	411	8	(	(	PUNCT
admet-2415	411	9	1984	1984	NUM
admet-2415	411	10	)	)	PUNCT
admet-2415	411	11	504	504	NUM
admet-2415	411	12	-	-	SYM
admet-2415	411	13	525	525	NUM
admet-2415	411	14	.	.	PUNCT
admet-2415	412	1	https://doi.org/10.1109/t-su.1984.31536	https://doi.org/10.1109/t-su.1984.31536	NOUN
admet-2415	413	1	[	[	X
admet-2415	413	2	36	36	NUM
admet-2415	413	3	]	]	X
admet-2415	413	4	y.f	y.f	PROPN
admet-2415	413	5	.	.	PUNCT
admet-2415	414	1	li	li	PROPN
admet-2415	414	2	,	,	PUNCT
admet-2415	414	3	c.	c.	PROPN
admet-2415	414	4	zhang	zhang	PROPN
admet-2415	414	5	,	,	PUNCT
admet-2415	414	6	s.	s.	PROPN
admet-2415	414	7	zhou	zhou	PROPN
admet-2415	414	8	,	,	PUNCT
admet-2415	414	9	m.	m.	NOUN
admet-2415	414	10	he	he	PRON
admet-2415	414	11	,	,	PUNCT
admet-2415	414	12	h.	h.	PROPN
admet-2415	414	13	zhang	zhang	PROPN
admet-2415	414	14	,	,	PUNCT
admet-2415	414	15	n.	n.	PROPN
admet-2415	414	16	chen	chen	PROPN
admet-2415	414	17	,	,	PUNCT
admet-2415	414	18	f.	f.	PROPN
admet-2415	414	19	li	li	PROPN
admet-2415	414	20	,	,	PUNCT
admet-2415	414	21	x.	x.	PROPN
admet-2415	414	22	luan	luan	PROPN
admet-2415	414	23	,	,	PUNCT
admet-2415	414	24	m.	m.	PROPN
admet-2415	414	25	pai	pai	PROPN
admet-2415	414	26	,	,	PUNCT
admet-2415	414	27	h.	h.	PROPN
admet-2415	414	28	yuan	yuan	PROPN
admet-2415	414	29	.	.	PUNCT
admet-2415	415	1	species	specie	NOUN
admet-2415	415	2	difference	difference	NOUN
admet-2415	415	3	in	in	ADP
admet-2415	415	4	paclitaxel	paclitaxel	ADJ
admet-2415	415	5	disposition	disposition	NOUN
admet-2415	415	6	correlated	correlate	VERB
admet-2415	415	7	with	with	ADP
admet-2415	415	8	poor	poor	ADJ
admet-2415	415	9	pharmacological	pharmacological	ADJ
admet-2415	415	10	efficacy	efficacy	NOUN
admet-2415	415	11	translation	translation	NOUN
admet-2415	415	12	from	from	ADP
admet-2415	415	13	mice	mouse	NOUN
admet-2415	415	14	to	to	ADP
admet-2415	415	15	humans	human	NOUN
admet-2415	415	16	.	.	PUNCT
admet-2415	416	1	clinical	clinical	ADJ
admet-2415	416	2	pharmacology	pharmacology	NOUN
admet-2415	416	3	:	:	PUNCT
admet-2415	416	4	advances	advance	NOUN
admet-2415	416	5	and	and	CCONJ
admet-2415	416	6	applications	application	NOUN
admet-2415	416	7	10	10	NUM
admet-2415	416	8	(	(	PUNCT
admet-2415	416	9	2018	2018	NUM
admet-2415	416	10	)	)	PUNCT
admet-2415	416	11	165	165	NUM
admet-2415	416	12	.	.	PUNCT
admet-2415	417	1	https://doi.org/10.2147/cpaa.s185449	https://doi.org/10.2147/cpaa.s185449	NOUN
admet-2415	418	1	©	©	PROPN
admet-2415	418	2	2024	2024	NUM
admet-2415	418	3	by	by	ADP
admet-2415	418	4	the	the	DET
admet-2415	418	5	authors	author	NOUN
admet-2415	418	6	;	;	PUNCT
admet-2415	418	7	licensee	licensee	PROPN
admet-2415	418	8	iapc	iapc	PROPN
admet-2415	418	9	,	,	PUNCT
admet-2415	418	10	zagreb	zagreb	PROPN
admet-2415	418	11	,	,	PUNCT
admet-2415	418	12	croatia	croatia	PROPN
admet-2415	418	13	.	.	PUNCT
admet-2415	419	1	this	this	DET
admet-2415	419	2	article	article	NOUN
admet-2415	419	3	is	be	AUX
admet-2415	419	4	an	an	DET
admet-2415	419	5	open	open	ADJ
admet-2415	419	6	-	-	PUNCT
admet-2415	419	7	access	access	NOUN
admet-2415	419	8	article	article	NOUN
admet-2415	419	9	distributed	distribute	VERB
admet-2415	419	10	under	under	ADP
admet-2415	419	11	the	the	DET
admet-2415	419	12	terms	term	NOUN
admet-2415	419	13	and	and	CCONJ
admet-2415	419	14	conditions	condition	NOUN
admet-2415	419	15	of	of	ADP
admet-2415	419	16	the	the	DET
admet-2415	419	17	creative	creative	ADJ
admet-2415	419	18	commons	common	NOUN
admet-2415	419	19	attribution	attribution	NOUN
admet-2415	419	20	license	license	NOUN
admet-2415	419	21	(	(	PUNCT
admet-2415	419	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2415	419	23	)	)	PUNCT
admet-2415	419	24	https://doi.org/10.5599/admet.2415	https://doi.org/10.5599/admet.2415	NOUN
admet-2415	420	1	https://doi.org/10.1002/0470870958	https://doi.org/10.1002/0470870958	PRON
admet-2415	420	2	https://doir.org/10.2165/00003088-199427040-00002	https://doir.org/10.2165/00003088-199427040-00002	VERB
admet-2415	420	3	https://doi.org/10.1109/t-su.1984.31536	https://doi.org/10.1109/t-su.1984.31536	PRON
admet-2415	420	4	https://doi.org/10.2147/cpaa.s185449	https://doi.org/10.2147/cpaa.s185449	INTJ
admet-2415	420	5	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN