id	sid	tid	token	lemma	pos
admet-2454	1	1	food	food	NOUN
admet-2454	1	2	and	and	CCONJ
admet-2454	1	3	bile	bile	NOUN
admet-2454	1	4	micelle	micelle	NOUN
admet-2454	1	5	binding	bind	VERB
admet-2454	1	6	of	of	ADP
admet-2454	1	7	zwitterionic	zwitterionic	ADJ
admet-2454	1	8	antihistamine	antihistamine	PROPN
admet-2454	1	9	drugs	drug	NOUN
admet-2454	1	10	doi	doi	PROPN
admet-2454	1	11	:	:	PUNCT
admet-2454	1	12	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	NOUN
admet-2454	1	13	649	649	NUM
admet-2454	1	14	admet	admet	X
admet-2454	1	15	&	&	CCONJ
admet-2454	1	16	dmpk	dmpk	PROPN
admet-2454	1	17	12(4	12(4	PROPN
admet-2454	1	18	)	)	PUNCT
admet-2454	1	19	(	(	PUNCT
admet-2454	1	20	2024	2024	NUM
admet-2454	1	21	)	)	PUNCT
admet-2454	1	22	649	649	NUM
admet-2454	1	23	-	-	SYM
admet-2454	1	24	656	656	NUM
admet-2454	1	25	;	;	PUNCT
admet-2454	1	26	doi	doi	NOUN
admet-2454	1	27	:	:	PUNCT
admet-2454	1	28	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	NOUN
admet-2454	1	29	open	open	ADJ
admet-2454	1	30	access	access	NOUN
admet-2454	1	31	:	:	PUNCT
admet-2454	1	32	issn	issn	PROPN
admet-2454	1	33	:	:	PUNCT
admet-2454	1	34	1848	1848	NUM
admet-2454	1	35	-	-	SYM
admet-2454	1	36	7718	7718	NUM
admet-2454	1	37	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2454	1	38	original	original	ADJ
admet-2454	1	39	scientific	scientific	ADJ
admet-2454	1	40	paper	paper	NOUN
admet-2454	1	41	food	food	NOUN
admet-2454	1	42	and	and	CCONJ
admet-2454	1	43	bile	bile	NOUN
admet-2454	1	44	micelle	micelle	NOUN
admet-2454	1	45	binding	bind	VERB
admet-2454	1	46	of	of	ADP
admet-2454	1	47	zwitterionic	zwitterionic	ADJ
admet-2454	1	48	antihistamine	antihistamine	PROPN
admet-2454	1	49	drugs	drug	NOUN
admet-2454	1	50	rie	rie	X
admet-2454	1	51	takeuchi	takeuchi	PROPN
admet-2454	1	52	and	and	CCONJ
admet-2454	1	53	kiyohiko	kiyohiko	PROPN
admet-2454	1	54	sugano	sugano	PROPN
admet-2454	1	55	*	*	PUNCT
admet-2454	1	56	molecular	molecular	ADJ
admet-2454	1	57	pharmaceutics	pharmaceutic	NOUN
admet-2454	1	58	lab	lab	NOUN
admet-2454	1	59	.	.	PUNCT
admet-2454	1	60	,	,	PUNCT
admet-2454	1	61	college	college	NOUN
admet-2454	1	62	of	of	ADP
admet-2454	1	63	pharmaceutical	pharmaceutical	NOUN
admet-2454	1	64	sciences	science	NOUN
admet-2454	1	65	,	,	PUNCT
admet-2454	1	66	ritsumeikan	ritsumeikan	ADJ
admet-2454	1	67	university	university	NOUN
admet-2454	1	68	,	,	PUNCT
admet-2454	1	69	1	1	NUM
admet-2454	1	70	-	-	SYM
admet-2454	1	71	1	1	NUM
admet-2454	1	72	-	-	SYM
admet-2454	1	73	1	1	NUM
admet-2454	1	74	,	,	PUNCT
admet-2454	1	75	noji	noji	NOUN
admet-2454	1	76	-	-	PUNCT
admet-2454	1	77	higashi	higashi	PROPN
admet-2454	1	78	,	,	PUNCT
admet-2454	1	79	kusatsu	kusatsu	NOUN
admet-2454	1	80	,	,	PUNCT
admet-2454	1	81	shiga	shiga	NOUN
admet-2454	1	82	525	525	NUM
admet-2454	1	83	-	-	SYM
admet-2454	1	84	8577	8577	NUM
admet-2454	1	85	,	,	PUNCT
admet-2454	1	86	japan	japan	PROPN
admet-2454	1	87	*	*	PUNCT
admet-2454	1	88	corresponding	correspond	VERB
admet-2454	1	89	authors	author	NOUN
admet-2454	1	90	:	:	PUNCT
admet-2454	1	91	e	e	X
admet-2454	1	92	-	-	NOUN
admet-2454	1	93	mail	mail	NOUN
admet-2454	1	94	:	:	PUNCT
admet-2454	1	95	suganok@fc.ritsumei.ac.jp	suganok@fc.ritsumei.ac.jp	NOUN
admet-2454	1	96	;	;	PUNCT
admet-2454	1	97	tel	tel	PROPN
admet-2454	1	98	.	.	PROPN
admet-2454	1	99	:	:	PUNCT
admet-2454	2	1	+81	+81	PROPN
admet-2454	2	2	-	-	PUNCT
admet-2454	2	3	77	77	NUM
admet-2454	2	4	-	-	PUNCT
admet-2454	2	5	561	561	NUM
admet-2454	2	6	-	-	PUNCT
admet-2454	2	7	2773	2773	NUM
admet-2454	2	8	received	receive	VERB
admet-2454	2	9	:	:	PUNCT
admet-2454	2	10	august	august	PROPN
admet-2454	2	11	1	1	NUM
admet-2454	2	12	,	,	PUNCT
admet-2454	2	13	2024	2024	NUM
admet-2454	2	14	;	;	PUNCT
admet-2454	2	15	revised	revise	VERB
admet-2454	2	16	:	:	PUNCT
admet-2454	2	17	august	august	PROPN
admet-2454	2	18	21	21	NUM
admet-2454	2	19	,	,	PUNCT
admet-2454	2	20	2024	2024	NUM
admet-2454	2	21	;	;	PUNCT
admet-2454	2	22	published	publish	VERB
admet-2454	2	23	:	:	PUNCT
admet-2454	2	24	august	august	PROPN
admet-2454	2	25	29	29	NUM
admet-2454	2	26	,	,	PUNCT
admet-2454	2	27	2024	2024	NUM
admet-2454	2	28	abstract	abstract	ADJ
admet-2454	2	29	background	background	NOUN
admet-2454	2	30	and	and	CCONJ
admet-2454	2	31	purpose	purpose	NOUN
admet-2454	2	32	:	:	PUNCT
admet-2454	2	33	the	the	DET
admet-2454	2	34	food	food	NOUN
admet-2454	2	35	effects	effect	NOUN
admet-2454	2	36	on	on	ADP
admet-2454	2	37	oral	oral	ADJ
admet-2454	2	38	drug	drug	NOUN
admet-2454	2	39	absorption	absorption	NOUN
admet-2454	2	40	are	be	AUX
admet-2454	2	41	challenging	challenge	VERB
admet-2454	2	42	to	to	PART
admet-2454	2	43	predict	predict	VERB
admet-2454	2	44	from	from	ADP
admet-2454	2	45	in	in	ADP
admet-2454	2	46	vitro	vitro	X
admet-2454	2	47	data	datum	NOUN
admet-2454	2	48	.	.	PUNCT
admet-2454	3	1	food	food	NOUN
admet-2454	3	2	intake	intake	NOUN
admet-2454	3	3	has	have	AUX
admet-2454	3	4	been	be	AUX
admet-2454	3	5	reported	report	VERB
admet-2454	3	6	to	to	PART
admet-2454	3	7	reduce	reduce	VERB
admet-2454	3	8	the	the	DET
admet-2454	3	9	oral	oral	ADJ
admet-2454	3	10	absorption	absorption	NOUN
admet-2454	3	11	of	of	ADP
admet-2454	3	12	several	several	ADJ
admet-2454	3	13	zwitterionic	zwitterionic	ADJ
admet-2454	3	14	antihistamine	antihistamine	NOUN
admet-2454	3	15	drugs	drug	NOUN
admet-2454	3	16	.	.	PUNCT
admet-2454	4	1	however	however	ADV
admet-2454	4	2	,	,	PUNCT
admet-2454	4	3	the	the	DET
admet-2454	4	4	mechanism	mechanism	NOUN
admet-2454	4	5	for	for	ADP
admet-2454	4	6	this	this	DET
admet-2454	4	7	negative	negative	ADJ
admet-2454	4	8	food	food	NOUN
admet-2454	4	9	effect	effect	NOUN
admet-2454	4	10	has	have	AUX
admet-2454	4	11	not	not	PART
admet-2454	4	12	been	be	AUX
admet-2454	4	13	clear	clear	ADJ
admet-2454	4	14	.	.	PUNCT
admet-2454	5	1	the	the	DET
admet-2454	5	2	purpose	purpose	NOUN
admet-2454	5	3	of	of	ADP
admet-2454	5	4	the	the	DET
admet-2454	5	5	present	present	ADJ
admet-2454	5	6	study	study	NOUN
admet-2454	5	7	was	be	AUX
admet-2454	5	8	to	to	PART
admet-2454	5	9	evaluate	evaluate	VERB
admet-2454	5	10	the	the	DET
admet-2454	5	11	bile	bile	NOUN
admet-2454	5	12	micelle	micelle	NOUN
admet-2454	5	13	and	and	CCONJ
admet-2454	5	14	food	food	NOUN
admet-2454	5	15	binding	bind	VERB
admet-2454	5	16	of	of	ADP
admet-2454	5	17	zwitterionic	zwitterionic	ADJ
admet-2454	5	18	antihistamine	antihistamine	NOUN
admet-2454	5	19	drugs	drug	NOUN
admet-2454	5	20	as	as	ADP
admet-2454	5	21	a	a	DET
admet-2454	5	22	possible	possible	ADJ
admet-2454	5	23	mechanism	mechanism	NOUN
admet-2454	5	24	for	for	ADP
admet-2454	5	25	the	the	DET
admet-2454	5	26	negative	negative	ADJ
admet-2454	5	27	food	food	NOUN
admet-2454	5	28	effects	effect	NOUN
admet-2454	5	29	on	on	ADP
admet-2454	5	30	their	their	PRON
admet-2454	5	31	oral	oral	ADJ
admet-2454	5	32	drug	drug	NOUN
admet-2454	5	33	absorption	absorption	NOUN
admet-2454	5	34	.	.	PUNCT
admet-2454	6	1	experimental	experimental	ADJ
admet-2454	6	2	approach	approach	NOUN
admet-2454	6	3	:	:	PUNCT
admet-2454	6	4	bilastine	bilastine	PROPN
admet-2454	6	5	(	(	PUNCT
admet-2454	6	6	bil	bil	NUM
admet-2454	6	7	)	)	PUNCT
admet-2454	6	8	,	,	PUNCT
admet-2454	6	9	cetirizine	cetirizine	NOUN
admet-2454	6	10	(	(	PUNCT
admet-2454	6	11	cet	cet	PROPN
admet-2454	6	12	)	)	PUNCT
admet-2454	6	13	,	,	PUNCT
admet-2454	6	14	fexofenadine	fexofenadine	PROPN
admet-2454	6	15	(	(	PUNCT
admet-2454	6	16	fex	fex	PROPN
admet-2454	6	17	)	)	PUNCT
admet-2454	6	18	,	,	PUNCT
admet-2454	6	19	and	and	CCONJ
admet-2454	6	20	olopatadine	olopatadine	NOUN
admet-2454	6	21	(	(	PUNCT
admet-2454	6	22	olo	olo	PROPN
admet-2454	6	23	)	)	PUNCT
admet-2454	6	24	were	be	AUX
admet-2454	6	25	employed	employ	VERB
admet-2454	6	26	as	as	ADP
admet-2454	6	27	model	model	NOUN
admet-2454	6	28	drugs	drug	NOUN
admet-2454	6	29	.	.	PUNCT
admet-2454	7	1	the	the	DET
admet-2454	7	2	fed	fed	PROPN
admet-2454	7	3	/	/	SYM
admet-2454	7	4	fasted	fast	VERB
admet-2454	7	5	auc	auc	NOUN
admet-2454	7	6	ratios	ratio	NOUN
admet-2454	7	7	of	of	ADP
admet-2454	7	8	bil	bil	NUM
admet-2454	7	9	,	,	PUNCT
admet-2454	7	10	cet	cet	PROPN
admet-2454	7	11	,	,	PUNCT
admet-2454	7	12	fex	fex	PROPN
admet-2454	7	13	,	,	PUNCT
admet-2454	7	14	and	and	CCONJ
admet-2454	7	15	olo	olo	PROPN
admet-2454	7	16	after	after	SCONJ
admet-2454	7	17	oral	oral	ADJ
admet-2454	7	18	administration	administration	NOUN
admet-2454	7	19	are	be	AUX
admet-2454	7	20	reported	report	VERB
admet-2454	7	21	to	to	PART
admet-2454	7	22	be	be	AUX
admet-2454	7	23	0.60	0.60	NUM
admet-2454	7	24	to	to	ADP
admet-2454	7	25	0.7	0.7	NUM
admet-2454	7	26	,	,	PUNCT
admet-2454	7	27	0.92	0.92	NUM
admet-2454	7	28	,	,	PUNCT
admet-2454	7	29	0.76	0.76	NUM
admet-2454	7	30	to	to	ADP
admet-2454	7	31	0.85	0.85	NUM
admet-2454	7	32	,	,	PUNCT
admet-2454	7	33	and	and	CCONJ
admet-2454	7	34	0.84	0.84	NUM
admet-2454	7	35	,	,	PUNCT
admet-2454	7	36	respectively	respectively	ADV
admet-2454	7	37	.	.	PUNCT
admet-2454	8	1	the	the	DET
admet-2454	8	2	unbound	unbound	NOUN
admet-2454	8	3	fraction	fraction	NOUN
admet-2454	8	4	(	(	PUNCT
admet-2454	8	5	fu	fu	NOUN
admet-2454	8	6	)	)	PUNCT
admet-2454	8	7	of	of	ADP
admet-2454	8	8	these	these	DET
admet-2454	8	9	drugs	drug	NOUN
admet-2454	8	10	in	in	ADP
admet-2454	8	11	the	the	DET
admet-2454	8	12	fasted	fast	VERB
admet-2454	8	13	and	and	CCONJ
admet-2454	8	14	fed	feed	VERB
admet-2454	8	15	state	state	NOUN
admet-2454	8	16	simulated	simulate	VERB
admet-2454	8	17	intestinal	intestinal	ADJ
admet-2454	8	18	fluids	fluid	NOUN
admet-2454	8	19	(	(	PUNCT
admet-2454	8	20	fassif	fassif	NOUN
admet-2454	8	21	and	and	CCONJ
admet-2454	8	22	fessif	fessif	NOUN
admet-2454	8	23	,	,	PUNCT
admet-2454	8	24	containing	contain	VERB
admet-2454	8	25	3	3	NUM
admet-2454	8	26	and	and	CCONJ
admet-2454	8	27	15	15	NUM
admet-2454	8	28	mm	mm	NOUN
admet-2454	8	29	taurocholic	taurocholic	ADJ
admet-2454	8	30	acid	acid	NOUN
admet-2454	8	31	,	,	PUNCT
admet-2454	8	32	respectively	respectively	ADV
admet-2454	8	33	)	)	PUNCT
admet-2454	8	34	with	with	ADP
admet-2454	8	35	or	or	CCONJ
admet-2454	8	36	without	without	ADP
admet-2454	8	37	fda	fda	PROPN
admet-2454	8	38	breakfast	breakfast	PROPN
admet-2454	8	39	homogenate	homogenate	NOUN
admet-2454	8	40	(	(	PUNCT
admet-2454	8	41	bfh	bfh	PROPN
admet-2454	8	42	)	)	PUNCT
admet-2454	8	43	was	be	AUX
admet-2454	8	44	measured	measure	VERB
admet-2454	8	45	by	by	ADP
admet-2454	8	46	dynamic	dynamic	ADJ
admet-2454	8	47	dialysis	dialysis	NOUN
admet-2454	8	48	.	.	PUNCT
admet-2454	9	1	key	key	ADJ
admet-2454	9	2	results	result	NOUN
admet-2454	9	3	:	:	PUNCT
admet-2454	9	4	the	the	DET
admet-2454	9	5	fessif/	fessif/	NUM
admet-2454	9	6	fassif	fassif	NOUN
admet-2454	9	7	fu	fu	PROPN
admet-2454	9	8	ratios	ratio	NOUN
admet-2454	9	9	were	be	AUX
admet-2454	9	10	0.90	0.90	NUM
admet-2454	9	11	(	(	PUNCT
admet-2454	9	12	bil	bil	NUM
admet-2454	9	13	)	)	PUNCT
admet-2454	9	14	,	,	PUNCT
admet-2454	9	15	0.46	0.46	NUM
admet-2454	9	16	(	(	PUNCT
admet-2454	9	17	cet	cet	PROPN
admet-2454	9	18	)	)	PUNCT
admet-2454	9	19	,	,	PUNCT
admet-2454	9	20	0.76	0.76	NUM
admet-2454	9	21	(	(	PUNCT
admet-2454	9	22	fex	fex	PROPN
admet-2454	9	23	)	)	PUNCT
admet-2454	9	24	,	,	PUNCT
admet-2454	9	25	and	and	CCONJ
admet-2454	9	26	0.78	0.78	NUM
admet-2454	9	27	(	(	PUNCT
admet-2454	9	28	olo	olo	PROPN
admet-2454	9	29	)	)	PUNCT
admet-2454	9	30	.	.	PUNCT
admet-2454	10	1	in	in	ADP
admet-2454	10	2	the	the	DET
admet-2454	10	3	presence	presence	NOUN
admet-2454	10	4	of	of	ADP
admet-2454	10	5	bfh	bfh	PROPN
admet-2454	10	6	,	,	PUNCT
admet-2454	10	7	the	the	DET
admet-2454	10	8	fu	fu	ADJ
admet-2454	10	9	ratios	ratio	NOUN
admet-2454	10	10	were	be	AUX
admet-2454	10	11	reduced	reduce	VERB
admet-2454	10	12	to	to	ADP
admet-2454	10	13	0.52	0.52	NUM
admet-2454	10	14	(	(	PUNCT
admet-2454	10	15	bil	bil	NUM
admet-2454	10	16	)	)	PUNCT
admet-2454	10	17	,	,	PUNCT
admet-2454	10	18	0.22	0.22	NUM
admet-2454	10	19	(	(	PUNCT
admet-2454	10	20	cet	cet	PROPN
admet-2454	10	21	)	)	PUNCT
admet-2454	10	22	,	,	PUNCT
admet-2454	10	23	0.39	0.39	NUM
admet-2454	10	24	(	(	PUNCT
admet-2454	10	25	fex	fex	PROPN
admet-2454	10	26	)	)	PUNCT
admet-2454	10	27	,	,	PUNCT
admet-2454	10	28	and	and	CCONJ
admet-2454	10	29	0.44	0.44	NUM
admet-2454	10	30	(	(	PUNCT
admet-2454	10	31	olo	olo	PROPN
admet-2454	10	32	)	)	PUNCT
admet-2454	10	33	.	.	PUNCT
admet-2454	11	1	conclusion	conclusion	NOUN
admet-2454	11	2	:	:	PUNCT
admet-2454	11	3	despite	despite	SCONJ
admet-2454	11	4	being	be	AUX
admet-2454	11	5	zwitterion	zwitterion	NOUN
admet-2454	11	6	at	at	ADP
admet-2454	11	7	ph	ph	PROPN
admet-2454	11	8	6.5	6.5	NUM
admet-2454	11	9	,	,	PUNCT
admet-2454	11	10	the	the	DET
admet-2454	11	11	antihistamine	antihistamine	NOUN
admet-2454	11	12	drugs	drug	NOUN
admet-2454	11	13	were	be	AUX
admet-2454	11	14	bound	bind	VERB
admet-2454	11	15	to	to	PART
admet-2454	11	16	bile	bile	NOUN
admet-2454	11	17	micelles	micelle	NOUN
admet-2454	11	18	.	.	PUNCT
admet-2454	12	1	bile	bile	NOUN
admet-2454	12	2	micelle	micelle	NOUN
admet-2454	12	3	and	and	CCONJ
admet-2454	12	4	food	food	NOUN
admet-2454	12	5	binding	bind	VERB
admet-2454	12	6	were	be	AUX
admet-2454	12	7	suggested	suggest	VERB
admet-2454	12	8	to	to	PART
admet-2454	12	9	cause	cause	VERB
admet-2454	12	10	a	a	DET
admet-2454	12	11	negative	negative	ADJ
admet-2454	12	12	food	food	NOUN
admet-2454	12	13	effect	effect	NOUN
admet-2454	12	14	on	on	ADP
admet-2454	12	15	the	the	DET
admet-2454	12	16	oral	oral	ADJ
admet-2454	12	17	absorption	absorption	NOUN
admet-2454	12	18	of	of	ADP
admet-2454	12	19	these	these	DET
admet-2454	12	20	drugs	drug	NOUN
admet-2454	12	21	.	.	PUNCT
admet-2454	13	1	however	however	ADV
admet-2454	13	2	,	,	PUNCT
admet-2454	13	3	the	the	DET
admet-2454	13	4	auc	auc	NOUN
admet-2454	13	5	ratio	ratio	NOUN
admet-2454	13	6	was	be	AUX
admet-2454	13	7	not	not	PART
admet-2454	13	8	quantitatively	quantitatively	ADV
admet-2454	13	9	predicted	predict	VERB
admet-2454	13	10	by	by	ADP
admet-2454	13	11	using	use	VERB
admet-2454	13	12	fessif	fessif	NOUN
admet-2454	13	13	+	+	CCONJ
admet-2454	13	14	bfh	bfh	NOUN
admet-2454	13	15	.	.	PUNCT
admet-2454	14	1	©	©	ADP
admet-2454	14	2	2024	2024	NUM
admet-2454	14	3	by	by	ADP
admet-2454	14	4	the	the	DET
admet-2454	14	5	authors	author	NOUN
admet-2454	14	6	.	.	PUNCT
admet-2454	15	1	this	this	DET
admet-2454	15	2	article	article	NOUN
admet-2454	15	3	is	be	AUX
admet-2454	15	4	an	an	DET
admet-2454	15	5	open	open	ADJ
admet-2454	15	6	-	-	PUNCT
admet-2454	15	7	access	access	NOUN
admet-2454	15	8	article	article	NOUN
admet-2454	15	9	distributed	distribute	VERB
admet-2454	15	10	under	under	ADP
admet-2454	15	11	the	the	DET
admet-2454	15	12	terms	term	NOUN
admet-2454	15	13	and	and	CCONJ
admet-2454	15	14	conditions	condition	NOUN
admet-2454	15	15	of	of	ADP
admet-2454	15	16	the	the	DET
admet-2454	15	17	creative	creative	ADJ
admet-2454	15	18	commons	common	NOUN
admet-2454	15	19	attribution	attribution	NOUN
admet-2454	15	20	license	license	NOUN
admet-2454	15	21	(	(	PUNCT
admet-2454	15	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2454	15	23	)	)	PUNCT
admet-2454	15	24	.	.	PUNCT
admet-2454	16	1	keywords	keyword	VERB
admet-2454	16	2	negative	negative	ADJ
admet-2454	16	3	food	food	NOUN
admet-2454	16	4	effect	effect	NOUN
admet-2454	16	5	;	;	PUNCT
admet-2454	16	6	unbound	unbound	NOUN
admet-2454	16	7	fraction	fraction	NOUN
admet-2454	16	8	;	;	PUNCT
admet-2454	16	9	simulated	simulate	VERB
admet-2454	16	10	intestinal	intestinal	ADJ
admet-2454	16	11	fluid	fluid	NOUN
admet-2454	16	12	;	;	PUNCT
admet-2454	16	13	dynamic	dynamic	ADJ
admet-2454	16	14	dialysis	dialysis	NOUN
admet-2454	16	15	;	;	PUNCT
admet-2454	16	16	intestinal	intestinal	ADJ
admet-2454	16	17	membrane	membrane	NOUN
admet-2454	16	18	permeation	permeation	NOUN
admet-2454	16	19	,	,	PUNCT
admet-2454	16	20	zwitterionic	zwitterionic	NOUN
admet-2454	16	21	,	,	PUNCT
admet-2454	16	22	antihistamine	antihistamine	NOUN
admet-2454	16	23	introduction	introduction	NOUN
admet-2454	16	24	the	the	DET
admet-2454	16	25	oral	oral	ADJ
admet-2454	16	26	absorption	absorption	NOUN
admet-2454	16	27	of	of	ADP
admet-2454	16	28	a	a	DET
admet-2454	16	29	drug	drug	NOUN
admet-2454	16	30	is	be	AUX
admet-2454	16	31	affected	affect	VERB
admet-2454	16	32	by	by	ADP
admet-2454	16	33	various	various	ADJ
admet-2454	16	34	physiological	physiological	ADJ
admet-2454	16	35	factors	factor	NOUN
admet-2454	16	36	in	in	ADP
admet-2454	16	37	the	the	DET
admet-2454	16	38	gastrointestinal	gastrointestinal	ADJ
admet-2454	16	39	tract	tract	NOUN
admet-2454	16	40	[	[	X
admet-2454	16	41	1	1	NUM
admet-2454	16	42	]	]	PUNCT
admet-2454	16	43	.	.	PUNCT
admet-2454	17	1	the	the	DET
admet-2454	17	2	physiological	physiological	ADJ
admet-2454	17	3	conditions	condition	NOUN
admet-2454	17	4	in	in	ADP
admet-2454	17	5	the	the	DET
admet-2454	17	6	fed	fed	PROPN
admet-2454	17	7	state	state	NOUN
admet-2454	17	8	are	be	AUX
admet-2454	17	9	markedly	markedly	ADV
admet-2454	17	10	different	different	ADJ
admet-2454	17	11	from	from	ADP
admet-2454	17	12	those	those	PRON
admet-2454	17	13	in	in	ADP
admet-2454	17	14	the	the	DET
admet-2454	17	15	fasted	fasted	ADJ
admet-2454	17	16	state	state	NOUN
admet-2454	17	17	.	.	PUNCT
admet-2454	18	1	for	for	ADP
admet-2454	18	2	example	example	NOUN
admet-2454	18	3	,	,	PUNCT
admet-2454	18	4	bile	bile	NOUN
admet-2454	18	5	micelle	micelle	NOUN
admet-2454	18	6	concentration	concentration	NOUN
admet-2454	18	7	is	be	AUX
admet-2454	18	8	significantly	significantly	ADV
admet-2454	18	9	increased	increase	VERB
admet-2454	18	10	in	in	ADP
admet-2454	18	11	the	the	DET
admet-2454	18	12	fed	fed	PROPN
admet-2454	18	13	state	state	NOUN
admet-2454	18	14	.	.	PUNCT
admet-2454	19	1	in	in	ADP
admet-2454	19	2	addition	addition	NOUN
admet-2454	19	3	,	,	PUNCT
admet-2454	19	4	food	food	NOUN
admet-2454	19	5	components	component	NOUN
admet-2454	19	6	can	can	AUX
admet-2454	19	7	interact	interact	VERB
admet-2454	19	8	with	with	ADP
admet-2454	19	9	drug	drug	NOUN
admet-2454	19	10	molecules	molecule	NOUN
admet-2454	19	11	.	.	PUNCT
admet-2454	20	1	it	it	PRON
admet-2454	20	2	is	be	AUX
admet-2454	20	3	still	still	ADV
admet-2454	20	4	challenging	challenge	VERB
admet-2454	20	5	to	to	PART
admet-2454	20	6	predict	predict	VERB
admet-2454	20	7	the	the	DET
admet-2454	20	8	food	food	NOUN
admet-2454	20	9	effects	effect	NOUN
admet-2454	20	10	on	on	ADP
admet-2454	20	11	oral	oral	ADJ
admet-2454	20	12	drug	drug	NOUN
admet-2454	20	13	absorption	absorption	NOUN
admet-2454	20	14	from	from	ADP
admet-2454	20	15	in	in	ADP
admet-2454	20	16	vitro	vitro	X
admet-2454	20	17	data	datum	NOUN
admet-2454	20	18	[	[	X
admet-2454	20	19	2	2	NUM
admet-2454	20	20	-	-	SYM
admet-2454	20	21	4	4	NUM
admet-2454	20	22	]	]	PUNCT
admet-2454	20	23	.	.	PUNCT
admet-2454	21	1	in	in	ADP
admet-2454	21	2	the	the	DET
admet-2454	21	3	mechanistic	mechanistic	ADJ
admet-2454	21	4	oral	oral	ADJ
admet-2454	21	5	absorption	absorption	NOUN
admet-2454	21	6	models	model	NOUN
admet-2454	21	7	,	,	PUNCT
admet-2454	21	8	the	the	DET
admet-2454	21	9	free	free	ADJ
admet-2454	21	10	(	(	PUNCT
admet-2454	21	11	unbound	unbound	ADJ
admet-2454	21	12	)	)	PUNCT
admet-2454	21	13	fraction	fraction	NOUN
admet-2454	21	14	in	in	ADP
admet-2454	21	15	the	the	DET
admet-2454	21	16	intestinal	intestinal	ADJ
admet-2454	21	17	fluid	fluid	NOUN
admet-2454	21	18	(	(	PUNCT
admet-2454	21	19	fu	fu	NOUN
admet-2454	21	20	)	)	PUNCT
admet-2454	21	21	is	be	AUX
admet-2454	21	22	one	one	NUM
admet-2454	21	23	of	of	ADP
admet-2454	21	24	the	the	DET
admet-2454	21	25	key	key	ADJ
admet-2454	21	26	parameters	parameter	NOUN
admet-2454	21	27	that	that	PRON
admet-2454	21	28	determine	determine	VERB
admet-2454	21	29	the	the	DET
admet-2454	21	30	effective	effective	ADJ
admet-2454	21	31	intestinal	intestinal	ADJ
admet-2454	21	32	permeability	permeability	NOUN
admet-2454	21	33	of	of	ADP
admet-2454	21	34	a	a	DET
admet-2454	21	35	drug	drug	NOUN
admet-2454	21	36	(	(	PUNCT
admet-2454	21	37	peff	peff	NOUN
admet-2454	21	38	)	)	PUNCT
admet-2454	22	1	[	[	X
admet-2454	22	2	5	5	NUM
admet-2454	22	3	]	]	PUNCT
admet-2454	22	4	.	.	PUNCT
admet-2454	23	1	high	high	ADJ
admet-2454	23	2	solubility/	solubility/	NUM
admet-2454	23	3	low	low	ADJ
admet-2454	23	4	permeability	permeability	NOUN
admet-2454	23	5	drugs	drug	NOUN
admet-2454	23	6	tend	tend	VERB
admet-2454	23	7	to	to	PART
admet-2454	23	8	show	show	VERB
admet-2454	23	9	a	a	DET
admet-2454	23	10	negative	negative	ADJ
admet-2454	23	11	food	food	NOUN
admet-2454	23	12	effect	effect	NOUN
admet-2454	23	13	.	.	PUNCT
admet-2454	24	1	in	in	ADP
admet-2454	24	2	these	these	DET
admet-2454	24	3	cases	case	NOUN
admet-2454	24	4	,	,	PUNCT
admet-2454	24	5	the	the	DET
admet-2454	24	6	rate	rate	NOUN
admet-2454	24	7	and	and	CCONJ
admet-2454	24	8	extent	extent	NOUN
admet-2454	24	9	of	of	ADP
admet-2454	24	10	fraction	fraction	NOUN
admet-2454	24	11	dose	dose	NOUN
admet-2454	24	12	absorbed	absorb	VERB
admet-2454	24	13	fa	fa	VERB
admet-2454	24	14	is	be	AUX
admet-2454	24	15	limited	limit	VERB
admet-2454	24	16	by	by	ADP
admet-2454	24	17	epithelial	epithelial	ADJ
admet-2454	24	18	membrane	membrane	NOUN
admet-2454	24	19	permeation	permeation	NOUN
admet-2454	24	20	(	(	PUNCT
admet-2454	24	21	fa	fa	INTJ
admet-2454	24	22	rate	rate	NOUN
admet-2454	24	23	-	-	PUNCT
admet-2454	24	24	limiting	limit	VERB
admet-2454	24	25	step	step	NOUN
admet-2454	24	26	(	(	PUNCT
admet-2454	24	27	farls	farl	NOUN
admet-2454	24	28	):	):	PUNCT
admet-2454	24	29	permeability	permeability	NOUN
admet-2454	24	30	-	-	PUNCT
admet-2454	24	31	limited	limit	VERB
admet-2454	24	32	(	(	PUNCT
admet-2454	24	33	pl	pl	NOUN
admet-2454	24	34	)	)	PUNCT
admet-2454	24	35	by	by	ADP
admet-2454	24	36	the	the	DET
admet-2454	24	37	epithelial	epithelial	ADJ
admet-2454	24	38	membrane	membrane	NOUN
admet-2454	24	39	(	(	PUNCT
admet-2454	24	40	pl	pl	NOUN
admet-2454	24	41	-	-	PUNCT
admet-2454	24	42	e	e	NOUN
admet-2454	24	43	)	)	PUNCT
admet-2454	24	44	)	)	PUNCT
admet-2454	25	1	[	[	X
admet-2454	25	2	2,6	2,6	NUM
admet-2454	25	3	]	]	PUNCT
admet-2454	25	4	.	.	PUNCT
admet-2454	26	1	recently	recently	ADV
admet-2454	26	2	,	,	PUNCT
admet-2454	26	3	the	the	DET
admet-2454	26	4	bile	bile	NOUN
admet-2454	26	5	micelle	micelle	NOUN
admet-2454	26	6	and	and	CCONJ
admet-2454	26	7	food	food	NOUN
admet-2454	26	8	binding	binding	NOUN
admet-2454	26	9	of	of	ADP
admet-2454	26	10	drugs	drug	NOUN
admet-2454	26	11	were	be	AUX
admet-2454	26	12	reported	report	VERB
admet-2454	26	13	to	to	PART
admet-2454	26	14	be	be	AUX
admet-2454	26	15	able	able	ADJ
admet-2454	26	16	to	to	PART
admet-2454	26	17	elucidate	elucidate	VERB
admet-2454	26	18	the	the	DET
admet-2454	26	19	negative	negative	ADJ
admet-2454	26	20	food	food	NOUN
admet-2454	26	21	effect	effect	NOUN
admet-2454	26	22	for	for	ADP
admet-2454	26	23	hydrophilic	hydrophilic	ADJ
admet-2454	26	24	tertiary	tertiary	ADJ
admet-2454	26	25	and	and	CCONJ
admet-2454	26	26	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	NOUN
admet-2454	26	27	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	PROPN
admet-2454	26	28	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-2454	26	29	mailto:suganok@fc.ritsumei.ac.jp	mailto:suganok@fc.ritsumei.ac.jp	PROPN
admet-2454	26	30	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2454	26	31	r.	r.	PROPN
admet-2454	26	32	takeuchi	takeuchi	PROPN
admet-2454	26	33	and	and	CCONJ
admet-2454	26	34	k.	k.	PROPN
admet-2454	26	35	sugano	sugano	PROPN
admet-2454	26	36	admet	admet	PROPN
admet-2454	26	37	&	&	CCONJ
admet-2454	26	38	dmpk	dmpk	PROPN
admet-2454	26	39	12(4	12(4	PROPN
admet-2454	26	40	)	)	PUNCT
admet-2454	26	41	(	(	PUNCT
admet-2454	26	42	2024	2024	NUM
admet-2454	26	43	)	)	PUNCT
admet-2454	26	44	649	649	NUM
admet-2454	26	45	-	-	SYM
admet-2454	26	46	656	656	NUM
admet-2454	26	47	650	650	NUM
admet-2454	26	48	quaternary	quaternary	ADJ
admet-2454	26	49	amines	amine	NOUN
admet-2454	26	50	[	[	X
admet-2454	26	51	5,7	5,7	NUM
admet-2454	26	52	]	]	PUNCT
admet-2454	26	53	.	.	PUNCT
admet-2454	27	1	some	some	DET
admet-2454	27	2	zwitterionic	zwitterionic	ADJ
admet-2454	27	3	antihistamine	antihistamine	NOUN
admet-2454	27	4	drugs	drug	NOUN
admet-2454	27	5	are	be	AUX
admet-2454	27	6	also	also	ADV
admet-2454	27	7	known	know	VERB
admet-2454	27	8	to	to	PART
admet-2454	27	9	show	show	VERB
admet-2454	27	10	negative	negative	ADJ
admet-2454	27	11	food	food	NOUN
admet-2454	27	12	effects	effect	NOUN
admet-2454	27	13	in	in	ADP
admet-2454	27	14	humans	human	NOUN
admet-2454	27	15	.	.	PUNCT
admet-2454	28	1	however	however	ADV
admet-2454	28	2	,	,	PUNCT
admet-2454	28	3	it	it	PRON
admet-2454	28	4	has	have	AUX
admet-2454	28	5	not	not	PART
admet-2454	28	6	been	be	AUX
admet-2454	28	7	clear	clear	ADJ
admet-2454	28	8	whether	whether	SCONJ
admet-2454	28	9	a	a	DET
admet-2454	28	10	zwitterionic	zwitterionic	ADJ
admet-2454	28	11	drug	drug	NOUN
admet-2454	28	12	can	can	AUX
admet-2454	28	13	also	also	ADV
admet-2454	28	14	bind	bind	VERB
admet-2454	28	15	to	to	ADP
admet-2454	28	16	bile	bile	NOUN
admet-2454	28	17	micelles	micelle	NOUN
admet-2454	28	18	and/or	and/or	CCONJ
admet-2454	28	19	food	food	NOUN
admet-2454	28	20	components	component	NOUN
admet-2454	28	21	.	.	PUNCT
admet-2454	29	1	the	the	DET
admet-2454	29	2	purpose	purpose	NOUN
admet-2454	29	3	of	of	ADP
admet-2454	29	4	the	the	DET
admet-2454	29	5	present	present	ADJ
admet-2454	29	6	study	study	NOUN
admet-2454	29	7	was	be	AUX
admet-2454	29	8	to	to	PART
admet-2454	29	9	investigate	investigate	VERB
admet-2454	29	10	whether	whether	SCONJ
admet-2454	29	11	zwitterionic	zwitterionic	ADJ
admet-2454	29	12	antihistamine	antihistamine	NOUN
admet-2454	29	13	drugs	drug	NOUN
admet-2454	29	14	can	can	AUX
admet-2454	29	15	bind	bind	VERB
admet-2454	29	16	to	to	ADP
admet-2454	29	17	bile	bile	NOUN
admet-2454	29	18	micelles	micelle	NOUN
admet-2454	29	19	and	and	CCONJ
admet-2454	29	20	food	food	NOUN
admet-2454	29	21	components	component	NOUN
admet-2454	29	22	.	.	PUNCT
admet-2454	30	1	bilastine	bilastine	PROPN
admet-2454	30	2	(	(	PUNCT
admet-2454	30	3	bil	bil	NUM
admet-2454	30	4	)	)	PUNCT
admet-2454	30	5	,	,	PUNCT
admet-2454	30	6	cetirizine	cetirizine	NOUN
admet-2454	30	7	(	(	PUNCT
admet-2454	30	8	cet	cet	PROPN
admet-2454	30	9	)	)	PUNCT
admet-2454	30	10	,	,	PUNCT
admet-2454	30	11	fexofenadine	fexofenadine	PROPN
admet-2454	30	12	(	(	PUNCT
admet-2454	30	13	fex	fex	PROPN
admet-2454	30	14	)	)	PUNCT
admet-2454	30	15	,	,	PUNCT
admet-2454	30	16	and	and	CCONJ
admet-2454	30	17	olopatadine	olopatadine	NOUN
admet-2454	30	18	(	(	PUNCT
admet-2454	30	19	olo	olo	PROPN
admet-2454	30	20	)	)	PUNCT
admet-2454	30	21	were	be	AUX
admet-2454	30	22	employed	employ	VERB
admet-2454	30	23	as	as	ADP
admet-2454	30	24	model	model	NOUN
admet-2454	30	25	drugs	drug	NOUN
admet-2454	30	26	(	(	PUNCT
admet-2454	30	27	figure	figure	NOUN
admet-2454	30	28	1	1	NUM
admet-2454	30	29	)	)	PUNCT
admet-2454	30	30	.	.	PUNCT
admet-2454	31	1	the	the	DET
admet-2454	31	2	physicochemical	physicochemical	ADJ
admet-2454	31	3	properties	property	NOUN
admet-2454	31	4	of	of	ADP
admet-2454	31	5	these	these	DET
admet-2454	31	6	drugs	drug	NOUN
admet-2454	31	7	are	be	AUX
admet-2454	31	8	shown	show	VERB
admet-2454	31	9	in	in	ADP
admet-2454	31	10	table	table	NOUN
admet-2454	31	11	1	1	NUM
admet-2454	31	12	.	.	PUNCT
admet-2454	32	1	these	these	DET
admet-2454	32	2	drugs	drug	NOUN
admet-2454	32	3	are	be	AUX
admet-2454	32	4	zwitterionic	zwitterionic	ADJ
admet-2454	32	5	and	and	CCONJ
admet-2454	32	6	show	show	VERB
admet-2454	32	7	moderate	moderate	ADJ
admet-2454	32	8	lipophilicity	lipophilicity	NOUN
admet-2454	32	9	at	at	ADP
admet-2454	32	10	ph	ph	PROPN
admet-2454	32	11	6.5	6.5	NUM
admet-2454	32	12	.	.	PUNCT
admet-2454	33	1	the	the	DET
admet-2454	33	2	fed	fed	PROPN
admet-2454	33	3	/	/	SYM
admet-2454	33	4	fasted	fast	VERB
admet-2454	33	5	auc	auc	NOUN
admet-2454	33	6	ratios	ratio	NOUN
admet-2454	33	7	of	of	ADP
admet-2454	33	8	bil	bil	NUM
admet-2454	33	9	,	,	PUNCT
admet-2454	33	10	cet	cet	PROPN
admet-2454	33	11	,	,	PUNCT
admet-2454	33	12	fex	fex	PROPN
admet-2454	33	13	,	,	PUNCT
admet-2454	33	14	and	and	CCONJ
admet-2454	33	15	olo	olo	PROPN
admet-2454	33	16	are	be	AUX
admet-2454	33	17	0.60	0.60	NUM
admet-2454	33	18	to	to	ADP
admet-2454	33	19	0.7	0.7	NUM
admet-2454	34	1	[	[	PUNCT
admet-2454	34	2	8	8	NUM
admet-2454	34	3	-	-	SYM
admet-2454	34	4	10	10	NUM
admet-2454	34	5	]	]	PUNCT
admet-2454	34	6	,	,	PUNCT
admet-2454	34	7	0.92	0.92	NUM
admet-2454	35	1	[	[	X
admet-2454	35	2	11	11	NUM
admet-2454	35	3	]	]	PUNCT
admet-2454	35	4	,	,	PUNCT
admet-2454	35	5	0.76	0.76	NUM
admet-2454	35	6	to	to	PART
admet-2454	35	7	0.85	0.85	NUM
admet-2454	36	1	[	[	X
admet-2454	36	2	12,13	12,13	NUM
admet-2454	36	3	]	]	PUNCT
admet-2454	36	4	,	,	PUNCT
admet-2454	36	5	and	and	CCONJ
admet-2454	36	6	0.84	0.84	NUM
admet-2454	37	1	[	[	X
admet-2454	37	2	14	14	NUM
admet-2454	37	3	]	]	PUNCT
admet-2454	37	4	,	,	PUNCT
admet-2454	37	5	respectively	respectively	ADV
admet-2454	37	6	.	.	PUNCT
admet-2454	38	1	in	in	ADP
admet-2454	38	2	this	this	DET
admet-2454	38	3	study	study	NOUN
admet-2454	38	4	,	,	PUNCT
admet-2454	38	5	dynamic	dynamic	ADJ
admet-2454	38	6	dialysis	dialysis	NOUN
admet-2454	38	7	was	be	AUX
admet-2454	38	8	used	use	VERB
admet-2454	38	9	to	to	PART
admet-2454	38	10	measure	measure	VERB
admet-2454	38	11	the	the	DET
admet-2454	38	12	fu	fu	ADJ
admet-2454	38	13	values	value	NOUN
admet-2454	38	14	in	in	ADP
admet-2454	38	15	the	the	DET
admet-2454	38	16	simulated	simulated	ADJ
admet-2454	38	17	intestinal	intestinal	ADJ
admet-2454	38	18	fluids	fluid	NOUN
admet-2454	38	19	consisting	consist	VERB
admet-2454	38	20	of	of	ADP
admet-2454	38	21	bile	bile	NOUN
admet-2454	38	22	micelles	micelle	NOUN
admet-2454	38	23	and	and	CCONJ
admet-2454	38	24	food	food	NOUN
admet-2454	38	25	homogenates	homogenate	NOUN
admet-2454	38	26	.	.	PUNCT
admet-2454	39	1	figure	figure	NOUN
admet-2454	39	2	1	1	NUM
admet-2454	39	3	.	.	PUNCT
admet-2454	40	1	chemical	chemical	NOUN
admet-2454	40	2	structures	structure	NOUN
admet-2454	40	3	of	of	ADP
admet-2454	40	4	zwitterionic	zwitterionic	ADJ
admet-2454	40	5	antihistamine	antihistamine	PROPN
admet-2454	40	6	model	model	NOUN
admet-2454	40	7	drugs	drug	NOUN
admet-2454	40	8	table	table	NOUN
admet-2454	40	9	1	1	NUM
admet-2454	40	10	.	.	PUNCT
admet-2454	40	11	physicochemical	physicochemical	ADJ
admet-2454	40	12	properties	property	NOUN
admet-2454	40	13	and	and	CCONJ
admet-2454	40	14	clinical	clinical	ADJ
admet-2454	40	15	data	datum	NOUN
admet-2454	40	16	of	of	ADP
admet-2454	40	17	model	model	NOUN
admet-2454	40	18	drugs	drug	NOUN
admet-2454	40	19	drug	drug	NOUN
admet-2454	40	20	mw	mw	X
admet-2454	40	21	pka	pka	PROPN
admet-2454	40	22	a	a	DET
admet-2454	40	23	isoelectric	isoelectric	ADJ
admet-2454	40	24	point	point	NOUN
admet-2454	40	25	log	log	NOUN
admet-2454	40	26	doct	doct	PROPN
admet-2454	40	27	ph	ph	PROPN
admet-2454	40	28	6.5b	6.5b	PROPN
admet-2454	40	29	dose	dose	PROPN
admet-2454	40	30	,	,	PUNCT
admet-2454	40	31	mg	mg	PROPN
admet-2454	40	32	food	food	NOUN
admet-2454	40	33	effect	effect	NOUN
admet-2454	40	34	,	,	PUNCT
admet-2454	40	35	%	%	INTJ
admet-2454	40	36	c	c	NOUN
admet-2454	40	37	bilastine	bilastine	VERB
admet-2454	40	38	464	464	NUM
admet-2454	40	39	4.0	4.0	NUM
admet-2454	40	40	(	(	PUNCT
admet-2454	40	41	a	a	X
admet-2454	40	42	)	)	PUNCT
admet-2454	40	43	8.8	8.8	NUM
admet-2454	40	44	(	(	PUNCT
admet-2454	40	45	b	b	NOUN
admet-2454	40	46	)	)	PUNCT
admet-2454	40	47	6.40	6.40	NUM
admet-2454	40	48	0.39	0.39	NUM
admet-2454	40	49	±	±	NUM
admet-2454	40	50	0.01	0.01	NUM
admet-2454	40	51	20	20	NUM
admet-2454	40	52	0.60	0.60	NUM
admet-2454	40	53	–	–	PUNCT
admet-2454	40	54	0.70	0.70	NUM
admet-2454	40	55	cetirizine	cetirizine	NOUN
admet-2454	40	56	389	389	NUM
admet-2454	40	57	2.12	2.12	NUM
admet-2454	40	58	(	(	PUNCT
admet-2454	40	59	b	b	NOUN
admet-2454	40	60	)	)	PUNCT
admet-2454	40	61	2.90	2.90	NUM
admet-2454	40	62	(	(	PUNCT
admet-2454	40	63	a	a	X
admet-2454	40	64	)	)	PUNCT
admet-2454	40	65	7.98	7.98	NUM
admet-2454	40	66	(	(	PUNCT
admet-2454	40	67	b	b	NOUN
admet-2454	40	68	)	)	PUNCT
admet-2454	40	69	5.44	5.44	NUM
admet-2454	40	70	1.46	1.46	NUM
admet-2454	40	71	±	±	NUM
admet-2454	40	72	0.01	0.01	NUM
admet-2454	40	73	10	10	NUM
admet-2454	40	74	0.92	0.92	NUM
admet-2454	40	75	fexofenadine	fexofenadine	NOUN
admet-2454	40	76	502	502	NUM
admet-2454	40	77	4.20	4.20	NUM
admet-2454	40	78	(	(	PUNCT
admet-2454	40	79	a	a	X
admet-2454	40	80	)	)	PUNCT
admet-2454	40	81	7.84	7.84	NUM
admet-2454	40	82	(	(	PUNCT
admet-2454	40	83	b	b	NOUN
admet-2454	40	84	)	)	PUNCT
admet-2454	40	85	6.02	6.02	NUM
admet-2454	40	86	0.51	0.51	NUM
admet-2454	40	87	±	±	NUM
admet-2454	40	88	0.01	0.01	NUM
admet-2454	40	89	120	120	NUM
admet-2454	40	90	0.76	0.76	NUM
admet-2454	40	91	–	–	SYM
admet-2454	40	92	0.85	0.85	NUM
admet-2454	40	93	olopatadine	olopatadine	NOUN
admet-2454	40	94	337	337	NUM
admet-2454	40	95	4.18	4.18	NUM
admet-2454	40	96	(	(	PUNCT
admet-2454	40	97	a	a	X
admet-2454	40	98	)	)	PUNCT
admet-2454	40	99	9.79	9.79	NUM
admet-2454	40	100	(	(	PUNCT
admet-2454	40	101	b	b	NOUN
admet-2454	40	102	)	)	PUNCT
admet-2454	40	103	6.99	6.99	NUM
admet-2454	40	104	0.34	0.34	NUM
admet-2454	40	105	±	±	NUM
admet-2454	40	106	0.01	0.01	NUM
admet-2454	40	107	10	10	NUM
admet-2454	40	108	0.84	0.84	NUM
admet-2454	40	109	a	a	DET
admet-2454	40	110	bilastine	bilastine	NOUN
admet-2454	40	111	(	(	PUNCT
admet-2454	40	112	estimated	estimate	VERB
admet-2454	40	113	from	from	ADP
admet-2454	40	114	the	the	DET
admet-2454	40	115	ph	ph	ADJ
admet-2454	40	116	log	log	NOUN
admet-2454	40	117	doct	doct	NOUN
admet-2454	40	118	profile	profile	NOUN
admet-2454	40	119	.	.	PUNCT
admet-2454	41	1	temperature	temperature	NOUN
admet-2454	41	2	and	and	CCONJ
admet-2454	41	3	ionic	ionic	ADJ
admet-2454	41	4	strength	strength	NOUN
admet-2454	41	5	not	not	PART
admet-2454	41	6	reported	report	VERB
admet-2454	41	7	)	)	PUNCT
admet-2454	42	1	[	[	X
admet-2454	42	2	8	8	NUM
admet-2454	42	3	]	]	PUNCT
admet-2454	42	4	,	,	PUNCT
admet-2454	42	5	cetirizine	cetirizine	NOUN
admet-2454	42	6	(	(	PUNCT
admet-2454	42	7	25	25	NUM
admet-2454	42	8	˚c	˚c	PROPN
admet-2454	42	9	,	,	PUNCT
admet-2454	42	10	i	i	NOUN
admet-2454	42	11	=	=	PROPN
admet-2454	42	12	0.15	0.15	NUM
admet-2454	42	13	m	m	PROPN
admet-2454	42	14	)	)	PUNCT
admet-2454	43	1	[	[	X
admet-2454	43	2	15	15	NUM
admet-2454	43	3	]	]	PUNCT
admet-2454	43	4	,	,	PUNCT
admet-2454	43	5	fexofenadine	fexofenadine	PROPN
admet-2454	43	6	(	(	PUNCT
admet-2454	43	7	24	24	NUM
admet-2454	43	8	˚c	˚c	PROPN
admet-2454	43	9	,	,	PUNCT
admet-2454	43	10	i	i	NOUN
admet-2454	43	11	=	=	NOUN
admet-2454	43	12	0.01	0.01	NUM
admet-2454	43	13	m	m	VERB
admet-2454	43	14	)	)	PUNCT
admet-2454	44	1	[	[	X
admet-2454	44	2	15	15	NUM
admet-2454	44	3	]	]	PUNCT
admet-2454	44	4	,	,	PUNCT
admet-2454	44	5	and	and	CCONJ
admet-2454	44	6	olopatadine	olopatadine	NOUN
admet-2454	44	7	(	(	PUNCT
admet-2454	44	8	temperature	temperature	NOUN
admet-2454	44	9	and	and	CCONJ
admet-2454	44	10	ionic	ionic	ADJ
admet-2454	44	11	strength	strength	NOUN
admet-2454	44	12	not	not	PART
admet-2454	44	13	reported	report	VERB
admet-2454	44	14	)	)	PUNCT
admet-2454	45	1	[	[	X
admet-2454	45	2	14	14	NUM
admet-2454	45	3	]	]	PUNCT
admet-2454	45	4	.	.	PUNCT
admet-2454	46	1	b	b	NOUN
admet-2454	46	2	measured	measure	VERB
admet-2454	46	3	in	in	ADP
admet-2454	46	4	this	this	DET
admet-2454	46	5	study	study	NOUN
admet-2454	46	6	c	c	NOUN
admet-2454	46	7	auc	auc	NOUN
admet-2454	46	8	ratio	ratio	NOUN
admet-2454	46	9	(	(	PUNCT
admet-2454	46	10	fed	fed	PROPN
admet-2454	46	11	/	/	SYM
admet-2454	46	12	fasted	fast	VERB
admet-2454	46	13	)	)	PUNCT
admet-2454	46	14	.	.	PUNCT
admet-2454	47	1	bilastine	bilastine	VERB
admet-2454	48	1	[	[	X
admet-2454	48	2	8	8	NUM
admet-2454	48	3	]	]	PUNCT
admet-2454	48	4	,	,	PUNCT
admet-2454	48	5	cetirizine	cetirizine	NOUN
admet-2454	49	1	[	[	X
admet-2454	49	2	11	11	NUM
admet-2454	49	3	]	]	PUNCT
admet-2454	49	4	,	,	PUNCT
admet-2454	49	5	fexofenadine	fexofenadine	VERB
admet-2454	50	1	[	[	X
admet-2454	50	2	12	12	NUM
admet-2454	50	3	]	]	PUNCT
admet-2454	50	4	and	and	CCONJ
admet-2454	50	5	olopatadine	olopatadine	NOUN
admet-2454	50	6	[	[	X
admet-2454	50	7	14	14	NUM
admet-2454	50	8	]	]	PUNCT
admet-2454	50	9	.	.	PUNCT
admet-2454	51	1	the	the	DET
admet-2454	51	2	permeation	permeation	NOUN
admet-2454	51	3	flux	flux	NOUN
admet-2454	51	4	(	(	PUNCT
admet-2454	51	5	j	j	NOUN
admet-2454	51	6	)	)	PUNCT
admet-2454	51	7	is	be	AUX
admet-2454	51	8	expressed	express	VERB
admet-2454	51	9	by	by	ADP
admet-2454	51	10	the	the	DET
admet-2454	51	11	total	total	ADJ
admet-2454	51	12	drug	drug	NOUN
admet-2454	51	13	concentration	concentration	NOUN
admet-2454	51	14	dissolved	dissolve	VERB
admet-2454	51	15	in	in	ADP
admet-2454	51	16	the	the	DET
admet-2454	51	17	gi	gi	NOUN
admet-2454	51	18	fluid	fluid	NOUN
admet-2454	51	19	(	(	PUNCT
admet-2454	51	20	cdissolv	cdissolv	NOUN
admet-2454	51	21	=	=	SYM
admet-2454	51	22	unbound	unbound	NOUN
admet-2454	51	23	+	+	CCONJ
admet-2454	51	24	bound	bind	VERB
admet-2454	51	25	)	)	PUNCT
admet-2454	51	26	and	and	CCONJ
admet-2454	51	27	the	the	DET
admet-2454	51	28	effective	effective	ADJ
admet-2454	51	29	(	(	PUNCT
admet-2454	51	30	apparent	apparent	ADJ
admet-2454	51	31	)	)	PUNCT
admet-2454	51	32	permeation	permeation	NOUN
admet-2454	51	33	coefficient	coefficient	NOUN
admet-2454	51	34	(	(	PUNCT
admet-2454	51	35	peff	peff	NOUN
admet-2454	51	36	)	)	PUNCT
admet-2454	51	37	as	as	ADP
admet-2454	51	38	in	in	ADP
admet-2454	51	39	equation	equation	NOUN
admet-2454	51	40	(	(	PUNCT
admet-2454	51	41	1	1	X
admet-2454	51	42	)	)	PUNCT
admet-2454	51	43	[	[	X
admet-2454	51	44	2	2	NUM
admet-2454	51	45	]	]	PUNCT
admet-2454	51	46	:	:	PUNCT
admet-2454	51	47	dissolv	dissolv	PROPN
admet-2454	51	48	effj	effj	PROPN
admet-2454	51	49	c	c	PROPN
admet-2454	51	50	p	p	PROPN
admet-2454	51	51	(	(	PUNCT
admet-2454	51	52	1	1	NUM
admet-2454	51	53	)	)	PUNCT
admet-2454	51	54	in	in	ADP
admet-2454	51	55	the	the	DET
admet-2454	51	56	case	case	NOUN
admet-2454	51	57	of	of	ADP
admet-2454	51	58	pl	pl	NOUN
admet-2454	51	59	-	-	PUNCT
admet-2454	51	60	e	e	NOUN
admet-2454	51	61	,	,	PUNCT
admet-2454	51	62	according	accord	VERB
admet-2454	51	63	to	to	ADP
admet-2454	51	64	the	the	DET
admet-2454	51	65	free	free	ADJ
admet-2454	51	66	fraction	fraction	NOUN
admet-2454	51	67	theory	theory	NOUN
admet-2454	51	68	,	,	PUNCT
admet-2454	51	69	only	only	ADV
admet-2454	51	70	unbound	unbound	NOUN
admet-2454	51	71	molecules	molecule	NOUN
admet-2454	51	72	can	can	AUX
admet-2454	51	73	permeate	permeate	VERB
admet-2454	51	74	the	the	DET
admet-2454	51	75	epithelial	epithelial	ADJ
admet-2454	51	76	membrane	membrane	NOUN
admet-2454	51	77	,	,	PUNCT
admet-2454	51	78	equation	equation	NOUN
admet-2454	51	79	(	(	PUNCT
admet-2454	51	80	2	2	NUM
admet-2454	51	81	)	)	PUNCT
admet-2454	51	82	,	,	PUNCT
admet-2454	51	83	eff	eff	PROPN
admet-2454	51	84	u	u	PROPN
admet-2454	51	85	ep	ep	PROPN
admet-2454	51	86	 	 	SPACE
admet-2454	51	87	p	p	PROPN
admet-2454	51	88	f	f	PROPN
admet-2454	51	89	p	p	PROPN
admet-2454	51	90	(	(	PUNCT
admet-2454	51	91	2	2	NUM
admet-2454	51	92	)	)	PUNCT
admet-2454	51	93	where	where	SCONJ
admet-2454	51	94	pep	pep	NOUN
admet-2454	51	95	is	be	AUX
admet-2454	51	96	the	the	DET
admet-2454	51	97	epithelial	epithelial	ADJ
admet-2454	51	98	membrane	membrane	NOUN
admet-2454	51	99	permeation	permeation	NOUN
admet-2454	51	100	coefficient	coefficient	NOUN
admet-2454	51	101	defined	define	VERB
admet-2454	51	102	based	base	VERB
admet-2454	51	103	on	on	ADP
admet-2454	51	104	the	the	DET
admet-2454	51	105	unbound	unbound	NOUN
admet-2454	51	106	drug	drug	NOUN
admet-2454	51	107	concentration	concentration	NOUN
admet-2454	51	108	,	,	PUNCT
admet-2454	51	109	and	and	CCONJ
admet-2454	51	110	fu	fu	NOUN
admet-2454	51	111	is	be	AUX
admet-2454	51	112	the	the	DET
admet-2454	51	113	unbound	unbound	NOUN
admet-2454	51	114	(	(	PUNCT
admet-2454	51	115	free	free	ADJ
admet-2454	51	116	)	)	PUNCT
admet-2454	51	117	fraction	fraction	NOUN
admet-2454	51	118	.	.	PUNCT
admet-2454	52	1	bile	bile	NOUN
admet-2454	52	2	micelle	micelle	NOUN
admet-2454	52	3	and	and	CCONJ
admet-2454	52	4	food	food	NOUN
admet-2454	52	5	binding	bind	VERB
admet-2454	52	6	can	can	AUX
admet-2454	52	7	reduce	reduce	VERB
admet-2454	52	8	the	the	DET
admet-2454	52	9	concentration	concentration	NOUN
admet-2454	52	10	of	of	ADP
admet-2454	52	11	admet	admet	PROPN
admet-2454	52	12	&	&	CCONJ
admet-2454	52	13	dmpk	dmpk	PROPN
admet-2454	52	14	12(4	12(4	PROPN
admet-2454	52	15	)	)	PUNCT
admet-2454	52	16	(	(	PUNCT
admet-2454	52	17	2024	2024	NUM
admet-2454	52	18	)	)	PUNCT
admet-2454	52	19	649	649	NUM
admet-2454	52	20	-	-	SYM
admet-2454	52	21	656	656	NUM
admet-2454	52	22	food	food	NOUN
admet-2454	52	23	and	and	CCONJ
admet-2454	52	24	bile	bile	NOUN
admet-2454	52	25	micelle	micelle	NOUN
admet-2454	52	26	binding	bind	VERB
admet-2454	52	27	of	of	ADP
admet-2454	52	28	zwitterionic	zwitterionic	ADJ
admet-2454	52	29	antihistamine	antihistamine	PROPN
admet-2454	52	30	drugs	drug	NOUN
admet-2454	52	31	doi	doi	PROPN
admet-2454	52	32	:	:	PUNCT
admet-2454	52	33	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	NOUN
admet-2454	52	34	651	651	NUM
admet-2454	52	35	unbound	unbound	NOUN
admet-2454	52	36	drug	drug	NOUN
admet-2454	52	37	molecules	molecule	NOUN
admet-2454	52	38	(=	(=	PROPN
admet-2454	52	39	fu	fu	PROPN
admet-2454	52	40	cdissolv	cdissolv	NOUN
admet-2454	52	41	)	)	PUNCT
admet-2454	52	42	at	at	ADP
admet-2454	52	43	the	the	DET
admet-2454	52	44	epithelial	epithelial	ADJ
admet-2454	52	45	membrane	membrane	NOUN
admet-2454	52	46	surface	surface	NOUN
admet-2454	52	47	.	.	PUNCT
admet-2454	53	1	in	in	ADP
admet-2454	53	2	the	the	DET
admet-2454	53	3	case	case	NOUN
admet-2454	53	4	when	when	SCONJ
admet-2454	53	5	the	the	DET
admet-2454	53	6	oral	oral	ADJ
admet-2454	53	7	absorption	absorption	NOUN
admet-2454	53	8	of	of	ADP
admet-2454	53	9	a	a	DET
admet-2454	53	10	drug	drug	NOUN
admet-2454	53	11	is	be	AUX
admet-2454	53	12	permeability	permeability	NOUN
admet-2454	53	13	-	-	PUNCT
admet-2454	53	14	limited	limit	VERB
admet-2454	53	15	,	,	PUNCT
admet-2454	53	16	fa	fa	PROPN
admet-2454	53	17	can	can	AUX
admet-2454	53	18	be	be	AUX
admet-2454	53	19	calculated	calculate	VERB
admet-2454	53	20	as	as	ADP
admet-2454	53	21	in	in	ADP
admet-2454	53	22	equation	equation	NOUN
admet-2454	53	23	(	(	PUNCT
admet-2454	53	24	3	3	NUM
admet-2454	53	25	)	)	PUNCT
admet-2454	53	26	eff1	eff1	NOUN
admet-2454	53	27	  	  	SPACE
admet-2454	53	28	a	a	DET
admet-2454	53	29	1	1	NUM
admet-2454	53	30	-	-	PUNCT
admet-2454	53	31	e	e	NOUN
admet-2454	53	32	apf	apf	PROPN
admet-2454	53	33	=	=	PUNCT
admet-2454	53	34	(	(	PUNCT
admet-2454	53	35	3	3	NUM
admet-2454	53	36	)	)	PUNCT
admet-2454	53	37	where	where	SCONJ
admet-2454	53	38	a	a	PRON
admet-2454	53	39	=	=	SYM
admet-2454	53	40	1.4	1.4	NUM
admet-2454	53	41	×	×	NOUN
admet-2454	53	42	104	104	NUM
admet-2454	53	43	s	s	PROPN
admet-2454	53	44	/	/	SYM
admet-2454	53	45	cm	cm	NOUN
admet-2454	53	46	(	(	PUNCT
admet-2454	53	47	peff	peff	PROPN
admet-2454	53	48	in	in	ADP
admet-2454	53	49	cm	cm	PROPN
admet-2454	53	50	/	/	SYM
admet-2454	53	51	s	s	NOUN
admet-2454	53	52	)	)	PUNCT
admet-2454	53	53	.	.	PUNCT
admet-2454	54	1	the	the	DET
admet-2454	54	2	fa	fa	PROPN
admet-2454	54	3	ratio	ratio	NOUN
admet-2454	54	4	(=	(=	NOUN
admet-2454	54	5	auc	auc	X
admet-2454	54	6	ratio	ratio	NOUN
admet-2454	54	7	)	)	PUNCT
admet-2454	54	8	in	in	ADP
admet-2454	54	9	the	the	DET
admet-2454	54	10	fasted	fasted	PROPN
admet-2454	54	11	/	/	SYM
admet-2454	54	12	fed	fed	PROPN
admet-2454	54	13	states	state	NOUN
admet-2454	54	14	approximately	approximately	ADV
admet-2454	54	15	becomes	become	VERB
admet-2454	54	16	the	the	DET
admet-2454	54	17	fu	fu	PROPN
admet-2454	54	18	ratio	ratio	NOUN
admet-2454	54	19	(	(	PUNCT
admet-2454	54	20	fu	fu	PROPN
admet-2454	54	21	,	,	PUNCT
admet-2454	54	22	fed	fed	PROPN
admet-2454	54	23	/	/	SYM
admet-2454	54	24	fu	fu	PROPN
admet-2454	54	25	,	,	PUNCT
admet-2454	54	26	fasted	fast	VERB
admet-2454	54	27	)	)	PUNCT
admet-2454	54	28	for	for	ADP
admet-2454	54	29	fa	fa	INTJ
admet-2454	54	30	<	<	X
admet-2454	54	31	0.7	0.7	NUM
admet-2454	54	32	cases	case	NOUN
admet-2454	54	33	[	[	X
admet-2454	54	34	2	2	NUM
admet-2454	54	35	]	]	PUNCT
admet-2454	54	36	.	.	PUNCT
admet-2454	55	1	experimental	experimental	ADJ
admet-2454	55	2	material	material	PROPN
admet-2454	55	3	fexofenadine	fexofenadine	PROPN
admet-2454	55	4	hydrochloride	hydrochloride	NOUN
admet-2454	55	5	,	,	PUNCT
admet-2454	55	6	bilastine	bilastine	ADJ
admet-2454	55	7	,	,	PUNCT
admet-2454	55	8	olopatadine	olopatadine	ADJ
admet-2454	55	9	hydrochloride	hydrochloride	NOUN
admet-2454	55	10	,	,	PUNCT
admet-2454	55	11	and	and	CCONJ
admet-2454	55	12	cetirizine	cetirizine	NOUN
admet-2454	55	13	dihydrochloride	dihydrochloride	NOUN
admet-2454	55	14	were	be	AUX
admet-2454	55	15	purchased	purchase	VERB
admet-2454	55	16	from	from	ADP
admet-2454	55	17	tokyo	tokyo	PROPN
admet-2454	55	18	chemical	chemical	PROPN
admet-2454	55	19	industry	industry	PROPN
admet-2454	55	20	co.	co.	PROPN
admet-2454	55	21	,	,	PUNCT
admet-2454	55	22	ltd	ltd	PROPN
admet-2454	55	23	(	(	PUNCT
admet-2454	55	24	tokyo	tokyo	PROPN
admet-2454	55	25	,	,	PUNCT
admet-2454	55	26	japan	japan	PROPN
admet-2454	55	27	)	)	PUNCT
admet-2454	55	28	.	.	PUNCT
admet-2454	56	1	sodium	sodium	NOUN
admet-2454	56	2	chloride	chloride	NOUN
admet-2454	56	3	(	(	PUNCT
admet-2454	56	4	nacl	nacl	NOUN
admet-2454	56	5	)	)	PUNCT
admet-2454	56	6	,	,	PUNCT
admet-2454	56	7	sodium	sodium	NOUN
admet-2454	56	8	dihydrogen	dihydrogen	NOUN
admet-2454	56	9	phosphate	phosphate	NOUN
admet-2454	56	10	dihydrate	dihydrate	NOUN
admet-2454	56	11	(	(	PUNCT
admet-2454	56	12	nah2po4	nah2po4	PROPN
admet-2454	56	13	2h2o	2h2o	NOUN
admet-2454	56	14	)	)	PUNCT
admet-2454	56	15	,	,	PUNCT
admet-2454	56	16	8n	8n	NOUN
admet-2454	56	17	naoh	naoh	NOUN
admet-2454	56	18	,	,	PUNCT
admet-2454	56	19	1	1	NUM
admet-2454	56	20	-	-	PUNCT
admet-2454	56	21	octanol	octanol	NOUN
admet-2454	56	22	,	,	PUNCT
admet-2454	56	23	taurocholic	taurocholic	ADJ
admet-2454	56	24	acid	acid	NOUN
admet-2454	56	25	(	(	PUNCT
admet-2454	56	26	tc	tc	NOUN
admet-2454	56	27	)	)	PUNCT
admet-2454	56	28	,	,	PUNCT
admet-2454	56	29	and	and	CCONJ
admet-2454	56	30	oleic	oleic	ADV
admet-2454	56	31	acid	acid	PROPN
admet-2454	56	32	(	(	PUNCT
admet-2454	56	33	oa	oa	NOUN
admet-2454	56	34	)	)	PUNCT
admet-2454	56	35	were	be	AUX
admet-2454	56	36	purchased	purchase	VERB
admet-2454	56	37	from	from	ADP
admet-2454	56	38	fujifilm	fujifilm	PROPN
admet-2454	56	39	wako	wako	PROPN
admet-2454	56	40	pure	pure	PROPN
admet-2454	56	41	chemical	chemical	PROPN
admet-2454	56	42	corporation	corporation	NOUN
admet-2454	56	43	(	(	PUNCT
admet-2454	56	44	osaka	osaka	PROPN
admet-2454	56	45	,	,	PUNCT
admet-2454	56	46	japan	japan	PROPN
admet-2454	56	47	)	)	PUNCT
admet-2454	56	48	.	.	PUNCT
admet-2454	57	1	egg	egg	NOUN
admet-2454	57	2	yolk	yolk	NOUN
admet-2454	57	3	lecithin	lecithin	NOUN
admet-2454	57	4	(	(	PUNCT
admet-2454	57	5	el	el	NOUN
admet-2454	57	6	)	)	PUNCT
admet-2454	57	7	was	be	AUX
admet-2454	57	8	purchased	purchase	VERB
admet-2454	57	9	from	from	ADP
admet-2454	57	10	kewpie	kewpie	PROPN
admet-2454	57	11	corporation	corporation	PROPN
admet-2454	57	12	(	(	PUNCT
admet-2454	57	13	tokyo	tokyo	PROPN
admet-2454	57	14	,	,	PUNCT
admet-2454	57	15	japan	japan	PROPN
admet-2454	57	16	)	)	PUNCT
admet-2454	57	17	.	.	PUNCT
admet-2454	58	1	glyceryl	glyceryl	NOUN
admet-2454	58	2	mono	mono	NOUN
admet-2454	58	3	-	-	PUNCT
admet-2454	58	4	oleate	oleate	ADJ
admet-2454	58	5	(	(	PUNCT
admet-2454	58	6	gm	gm	PROPN
admet-2454	58	7	)	)	PUNCT
admet-2454	58	8	was	be	AUX
admet-2454	58	9	purchased	purchase	VERB
admet-2454	58	10	from	from	ADP
admet-2454	58	11	nippon	nippon	PROPN
admet-2454	58	12	surfactant	surfactant	PROPN
admet-2454	58	13	industries	industries	PROPN
admet-2454	58	14	co.	co.	PROPN
admet-2454	58	15	,	,	PUNCT
admet-2454	58	16	ltd	ltd	PROPN
admet-2454	58	17	(	(	PUNCT
admet-2454	58	18	tokyo	tokyo	PROPN
admet-2454	58	19	,	,	PUNCT
admet-2454	58	20	japan	japan	PROPN
admet-2454	58	21	)	)	PUNCT
admet-2454	58	22	.	.	PUNCT
admet-2454	59	1	a	a	DET
admet-2454	59	2	cellulose	cellulose	NOUN
admet-2454	59	3	dialysis	dialysis	NOUN
admet-2454	59	4	membrane	membrane	NOUN
admet-2454	59	5	(	(	PUNCT
admet-2454	59	6	φ	φ	PROPN
admet-2454	59	7	15.9×25	15.9×25	PROPN
admet-2454	59	8	mm×15	mm×15	PROPN
admet-2454	59	9	m	m	NOUN
admet-2454	59	10	)	)	PUNCT
admet-2454	59	11	was	be	AUX
admet-2454	59	12	purchased	purchase	VERB
admet-2454	59	13	from	from	ADP
admet-2454	59	14	as	as	ADP
admet-2454	59	15	-	-	PUNCT
admet-2454	59	16	one	one	NUM
admet-2454	59	17	corporation	corporation	NOUN
admet-2454	59	18	(	(	PUNCT
admet-2454	59	19	osaka	osaka	PROPN
admet-2454	59	20	,	,	PUNCT
admet-2454	59	21	japan	japan	PROPN
admet-2454	59	22	)	)	PUNCT
admet-2454	59	23	.	.	PUNCT
admet-2454	60	1	the	the	DET
admet-2454	60	2	fda	fda	PROPN
admet-2454	60	3	breakfast	breakfast	NOUN
admet-2454	60	4	ingredients	ingredient	NOUN
admet-2454	60	5	,	,	PUNCT
admet-2454	60	6	and	and	CCONJ
admet-2454	60	7	other	other	ADJ
admet-2454	60	8	food	food	NOUN
admet-2454	60	9	were	be	AUX
admet-2454	60	10	purchased	purchase	VERB
admet-2454	60	11	from	from	ADP
admet-2454	60	12	the	the	DET
admet-2454	60	13	local	local	ADJ
admet-2454	60	14	market	market	NOUN
admet-2454	60	15	(	(	PUNCT
admet-2454	60	16	bacon	bacon	NOUN
admet-2454	60	17	(	(	PUNCT
admet-2454	60	18	itoham	itoham	PROPN
admet-2454	60	19	foods	foods	PROPN
admet-2454	60	20	inc	inc	PROPN
admet-2454	60	21	,	,	PUNCT
admet-2454	60	22	japan	japan	PROPN
admet-2454	60	23	)	)	PUNCT
admet-2454	60	24	,	,	PUNCT
admet-2454	60	25	toast	toast	NOUN
admet-2454	60	26	(	(	PUNCT
admet-2454	60	27	choujuku	choujuku	NOUN
admet-2454	60	28	bread	bread	NOUN
admet-2454	60	29	,	,	PUNCT
admet-2454	60	30	pasco	pasco	PROPN
admet-2454	60	31	shikishima	shikishima	PROPN
admet-2454	60	32	corporation	corporation	PROPN
admet-2454	60	33	,	,	PUNCT
admet-2454	60	34	japan	japan	PROPN
admet-2454	60	35	)	)	PUNCT
admet-2454	60	36	,	,	PUNCT
admet-2454	60	37	egg	egg	NOUN
admet-2454	60	38	(	(	PUNCT
admet-2454	60	39	akadama	akadama	PROPN
admet-2454	60	40	,	,	PUNCT
admet-2454	60	41	miwa	miwa	PROPN
admet-2454	60	42	keien	keien	PROPN
admet-2454	60	43	co.	co.	PROPN
admet-2454	60	44	,	,	PUNCT
admet-2454	60	45	ltd	ltd	PROPN
admet-2454	60	46	,	,	PUNCT
admet-2454	60	47	japan	japan	PROPN
admet-2454	60	48	)	)	PUNCT
admet-2454	60	49	,	,	PUNCT
admet-2454	60	50	hash	hash	NOUN
admet-2454	60	51	browns	brown	NOUN
admet-2454	60	52	(	(	PUNCT
admet-2454	60	53	hoshino	hoshino	NOUN
admet-2454	60	54	potato	potato	NOUN
admet-2454	60	55	,	,	PUNCT
admet-2454	60	56	heinz	heinz	PROPN
admet-2454	60	57	japan	japan	PROPN
admet-2454	60	58	ltd	ltd	PROPN
admet-2454	60	59	,	,	PUNCT
admet-2454	60	60	japan	japan	PROPN
admet-2454	60	61	)	)	PUNCT
admet-2454	60	62	,	,	PUNCT
admet-2454	60	63	whole	whole	ADJ
admet-2454	60	64	milk	milk	NOUN
admet-2454	60	65	(	(	PUNCT
admet-2454	60	66	oishii	oishii	PROPN
admet-2454	60	67	megumilk	megumilk	PROPN
admet-2454	60	68	snow	snow	PROPN
admet-2454	60	69	brand	brand	PROPN
admet-2454	60	70	milk	milk	NOUN
admet-2454	60	71	,	,	PUNCT
admet-2454	60	72	megmilk	megmilk	NOUN
admet-2454	60	73	snow	snow	PROPN
admet-2454	60	74	brand	brand	PROPN
admet-2454	60	75	co.	co.	PROPN
admet-2454	60	76	,	,	PUNCT
admet-2454	60	77	ltd	ltd	PROPN
admet-2454	60	78	,	,	PUNCT
admet-2454	60	79	japan	japan	PROPN
admet-2454	60	80	)	)	PUNCT
admet-2454	60	81	,	,	PUNCT
admet-2454	60	82	butter	butter	NOUN
admet-2454	60	83	(	(	PUNCT
admet-2454	60	84	hokkaido	hokkaido	NOUN
admet-2454	60	85	-	-	PUNCT
admet-2454	60	86	butter	butter	NOUN
admet-2454	60	87	,	,	PUNCT
admet-2454	60	88	megmilk	megmilk	NOUN
admet-2454	60	89	snow	snow	PROPN
admet-2454	60	90	brand	brand	PROPN
admet-2454	60	91	co.	co.	PROPN
admet-2454	60	92	,	,	PUNCT
admet-2454	60	93	ltd	ltd	PROPN
admet-2454	60	94	,	,	PUNCT
admet-2454	60	95	japan	japan	PROPN
admet-2454	60	96	)	)	PUNCT
admet-2454	60	97	.	.	PUNCT
admet-2454	61	1	methods	method	NOUN
admet-2454	61	2	processing	processing	NOUN
admet-2454	61	3	of	of	ADP
admet-2454	61	4	fda	fda	PROPN
admet-2454	61	5	breakfast	breakfast	NOUN
admet-2454	61	6	the	the	DET
admet-2454	61	7	fda	fda	PROPN
admet-2454	61	8	breakfast	breakfast	NOUN
admet-2454	61	9	was	be	AUX
admet-2454	61	10	comprised	comprise	VERB
admet-2454	61	11	of	of	ADP
admet-2454	61	12	one	one	NUM
admet-2454	61	13	strip	strip	NOUN
admet-2454	61	14	of	of	ADP
admet-2454	61	15	bacon	bacon	NOUN
admet-2454	61	16	,	,	PUNCT
admet-2454	61	17	half	half	DET
admet-2454	61	18	a	a	DET
admet-2454	61	19	slice	slice	NOUN
admet-2454	61	20	of	of	ADP
admet-2454	61	21	toast	toast	NOUN
admet-2454	61	22	,	,	PUNCT
admet-2454	61	23	one	one	NUM
admet-2454	61	24	fried	fry	VERB
admet-2454	61	25	egg	egg	NOUN
admet-2454	61	26	,	,	PUNCT
admet-2454	61	27	55	55	NUM
admet-2454	61	28	g	g	NOUN
admet-2454	61	29	of	of	ADP
admet-2454	61	30	hash	hash	NOUN
admet-2454	61	31	browns	brown	NOUN
admet-2454	61	32	,	,	PUNCT
admet-2454	61	33	30	30	NUM
admet-2454	61	34	g	g	NOUN
admet-2454	61	35	of	of	ADP
admet-2454	61	36	butter	butter	NOUN
admet-2454	61	37	,	,	PUNCT
admet-2454	61	38	and	and	CCONJ
admet-2454	61	39	100	100	NUM
admet-2454	61	40	ml	ml	NOUN
admet-2454	61	41	of	of	ADP
admet-2454	61	42	whole	whole	ADJ
admet-2454	61	43	milk	milk	NOUN
admet-2454	61	44	.	.	PUNCT
admet-2454	62	1	after	after	ADP
admet-2454	62	2	cooking	cook	VERB
admet-2454	62	3	,	,	PUNCT
admet-2454	62	4	the	the	DET
admet-2454	62	5	fda	fda	PROPN
admet-2454	62	6	breakfast	breakfast	NOUN
admet-2454	62	7	was	be	AUX
admet-2454	62	8	homogenized	homogenize	VERB
admet-2454	62	9	for	for	ADP
admet-2454	62	10	15	15	NUM
admet-2454	62	11	s	s	NOUN
admet-2454	62	12	by	by	ADP
admet-2454	62	13	a	a	DET
admet-2454	62	14	food	food	NOUN
admet-2454	62	15	processor	processor	NOUN
admet-2454	62	16	.	.	PUNCT
admet-2454	63	1	the	the	DET
admet-2454	63	2	fda	fda	PROPN
admet-2454	63	3	breakfast	breakfast	PROPN
admet-2454	63	4	homogenate	homogenate	NOUN
admet-2454	63	5	(	(	PUNCT
admet-2454	63	6	bfh	bfh	PROPN
admet-2454	63	7	)	)	PUNCT
admet-2454	63	8	was	be	AUX
admet-2454	63	9	divided	divide	VERB
admet-2454	63	10	into	into	ADP
admet-2454	63	11	small	small	ADJ
admet-2454	63	12	aliquots	aliquot	NOUN
admet-2454	63	13	and	and	CCONJ
admet-2454	63	14	stored	store	VERB
admet-2454	63	15	in	in	ADP
admet-2454	63	16	a	a	DET
admet-2454	63	17	freezer	freezer	NOUN
admet-2454	63	18	(	(	PUNCT
admet-2454	63	19	-30	-30	PROPN
admet-2454	63	20	°	°	PROPN
admet-2454	63	21	c	c	NOUN
admet-2454	63	22	)	)	PUNCT
admet-2454	63	23	.	.	PUNCT
admet-2454	64	1	it	it	PRON
admet-2454	64	2	was	be	AUX
admet-2454	64	3	thawed	thaw	VERB
admet-2454	64	4	under	under	ADP
admet-2454	64	5	running	run	VERB
admet-2454	64	6	water	water	NOUN
admet-2454	64	7	before	before	ADP
admet-2454	64	8	use	use	NOUN
admet-2454	64	9	.	.	PUNCT
admet-2454	65	1	measurement	measurement	NOUN
admet-2454	65	2	of	of	ADP
admet-2454	65	3	the	the	DET
admet-2454	65	4	unbound	unbound	NOUN
admet-2454	65	5	fraction	fraction	NOUN
admet-2454	65	6	by	by	ADP
admet-2454	65	7	dynamic	dynamic	ADJ
admet-2454	65	8	dialysis	dialysis	NOUN
admet-2454	65	9	dynamic	dynamic	ADJ
admet-2454	65	10	dialysis	dialysis	NOUN
admet-2454	65	11	was	be	AUX
admet-2454	65	12	performed	perform	VERB
admet-2454	65	13	using	use	VERB
admet-2454	65	14	a	a	DET
admet-2454	65	15	side	side	NOUN
admet-2454	65	16	-	-	PUNCT
admet-2454	65	17	by	by	ADP
admet-2454	65	18	-	-	PUNCT
admet-2454	65	19	side	side	NOUN
admet-2454	65	20	chamber	chamber	NOUN
admet-2454	65	21	(	(	PUNCT
admet-2454	65	22	sanplatec	sanplatec	PROPN
admet-2454	65	23	co.	co.	PROPN
admet-2454	65	24	,	,	PUNCT
admet-2454	65	25	ltd	ltd	PROPN
admet-2454	65	26	(	(	PUNCT
admet-2454	65	27	osaka	osaka	PROPN
admet-2454	65	28	,	,	PUNCT
admet-2454	65	29	japan	japan	PROPN
admet-2454	65	30	)	)	PUNCT
admet-2454	65	31	)	)	PUNCT
admet-2454	65	32	with	with	ADP
admet-2454	65	33	a	a	DET
admet-2454	65	34	cellulose	cellulose	NOUN
admet-2454	65	35	dialysis	dialysis	NOUN
admet-2454	65	36	membrane	membrane	NOUN
admet-2454	65	37	(	(	PUNCT
admet-2454	65	38	molecular	molecular	ADJ
admet-2454	65	39	weight	weight	NOUN
admet-2454	65	40	cut	cut	NOUN
admet-2454	65	41	-	-	PUNCT
admet-2454	65	42	off	off	ADP
admet-2454	65	43	:	:	PUNCT
admet-2454	65	44	3500	3500	NUM
admet-2454	65	45	)	)	PUNCT
admet-2454	65	46	.	.	PUNCT
admet-2454	66	1	the	the	DET
admet-2454	66	2	membrane	membrane	NOUN
admet-2454	66	3	area	area	NOUN
admet-2454	66	4	was	be	AUX
admet-2454	66	5	2.0	2.0	NUM
admet-2454	66	6	cm2	cm2	NOUN
admet-2454	66	7	.	.	PUNCT
admet-2454	67	1	the	the	DET
admet-2454	67	2	fluid	fluid	ADJ
admet-2454	67	3	volume	volume	NOUN
admet-2454	67	4	was	be	AUX
admet-2454	67	5	1.5	1.5	NUM
admet-2454	67	6	ml	ml	NOUN
admet-2454	67	7	for	for	ADP
admet-2454	67	8	both	both	CCONJ
admet-2454	67	9	the	the	DET
admet-2454	67	10	donor	donor	NOUN
admet-2454	67	11	and	and	CCONJ
admet-2454	67	12	acceptor	acceptor	NOUN
admet-2454	67	13	sides	side	NOUN
admet-2454	67	14	.	.	PUNCT
admet-2454	68	1	the	the	DET
admet-2454	68	2	fasted	fast	VERB
admet-2454	68	3	and	and	CCONJ
admet-2454	68	4	fed	feed	VERB
admet-2454	68	5	state	state	NOUN
admet-2454	68	6	simulated	simulate	VERB
admet-2454	68	7	intestinal	intestinal	ADJ
admet-2454	68	8	fluids	fluid	NOUN
admet-2454	68	9	(	(	PUNCT
admet-2454	68	10	fassif	fassif	NOUN
admet-2454	68	11	and	and	CCONJ
admet-2454	68	12	fessif	fessif	NOUN
admet-2454	68	13	,	,	PUNCT
admet-2454	68	14	respectively	respectively	ADV
admet-2454	68	15	)	)	PUNCT
admet-2454	68	16	with	with	ADP
admet-2454	68	17	or	or	CCONJ
admet-2454	68	18	without	without	ADP
admet-2454	68	19	bfh	bfh	NOUN
admet-2454	68	20	were	be	AUX
admet-2454	68	21	used	use	VERB
admet-2454	68	22	as	as	ADP
admet-2454	68	23	test	test	NOUN
admet-2454	68	24	media	medium	NOUN
admet-2454	68	25	(	(	PUNCT
admet-2454	68	26	table	table	NOUN
admet-2454	68	27	2	2	NUM
admet-2454	68	28	)	)	PUNCT
admet-2454	68	29	.	.	PUNCT
admet-2454	69	1	each	each	DET
admet-2454	69	2	drug	drug	NOUN
admet-2454	69	3	was	be	AUX
admet-2454	69	4	dissolved	dissolve	VERB
admet-2454	69	5	in	in	ADP
admet-2454	69	6	the	the	DET
admet-2454	69	7	test	test	NOUN
admet-2454	69	8	media	medium	NOUN
admet-2454	69	9	and	and	CCONJ
admet-2454	69	10	added	add	VERB
admet-2454	69	11	to	to	ADP
admet-2454	69	12	the	the	DET
admet-2454	69	13	donor	donor	NOUN
admet-2454	69	14	side	side	NOUN
admet-2454	69	15	(	(	PUNCT
admet-2454	69	16	0.04	0.04	NUM
admet-2454	69	17	mm	mm	NOUN
admet-2454	69	18	(	(	PUNCT
admet-2454	69	19	bil	bil	NUM
admet-2454	69	20	)	)	PUNCT
admet-2454	69	21	,	,	PUNCT
admet-2454	69	22	0.2	0.2	NUM
admet-2454	69	23	mm	mm	INTJ
admet-2454	69	24	(	(	PUNCT
admet-2454	69	25	ctz	ctz	PROPN
admet-2454	69	26	)	)	PUNCT
admet-2454	69	27	,	,	PUNCT
admet-2454	69	28	0.5	0.5	NUM
admet-2454	69	29	mm	mm	NOUN
admet-2454	69	30	(	(	PUNCT
admet-2454	69	31	fex	fex	PROPN
admet-2454	69	32	)	)	PUNCT
admet-2454	69	33	,	,	PUNCT
admet-2454	69	34	and	and	CCONJ
admet-2454	69	35	0.5	0.5	NUM
admet-2454	69	36	mm	mm	PROPN
admet-2454	69	37	(	(	PUNCT
admet-2454	69	38	olo	olo	PROPN
admet-2454	69	39	)	)	PUNCT
admet-2454	69	40	)	)	PUNCT
admet-2454	69	41	.	.	PUNCT
admet-2454	70	1	the	the	DET
admet-2454	70	2	blank	blank	ADJ
admet-2454	70	3	fassif	fassif	NOUN
admet-2454	70	4	was	be	AUX
admet-2454	70	5	added	add	VERB
admet-2454	70	6	to	to	ADP
admet-2454	70	7	the	the	DET
admet-2454	70	8	acceptor	acceptor	NOUN
admet-2454	70	9	side	side	NOUN
admet-2454	70	10	.	.	PUNCT
admet-2454	71	1	after	after	ADP
admet-2454	71	2	incubation	incubation	NOUN
admet-2454	71	3	for	for	ADP
admet-2454	71	4	1	1	NUM
admet-2454	71	5	h	h	NOUN
admet-2454	71	6	at	at	ADP
admet-2454	71	7	37	37	NUM
admet-2454	71	8	°	°	NOUN
admet-2454	71	9	c	c	NOUN
admet-2454	71	10	,	,	PUNCT
admet-2454	71	11	the	the	DET
admet-2454	71	12	drug	drug	NOUN
admet-2454	71	13	concentration	concentration	NOUN
admet-2454	71	14	in	in	ADP
admet-2454	71	15	the	the	DET
admet-2454	71	16	acceptor	acceptor	NOUN
admet-2454	71	17	side	side	NOUN
admet-2454	71	18	was	be	AUX
admet-2454	71	19	measured	measure	VERB
admet-2454	71	20	by	by	ADP
admet-2454	71	21	hplc	hplc	NOUN
admet-2454	71	22	(	(	PUNCT
admet-2454	71	23	shimazu	shimazu	ADJ
admet-2454	71	24	prominence	prominence	NOUN
admet-2454	71	25	lc-20	lc-20	PRON
admet-2454	71	26	series	series	PROPN
admet-2454	71	27	and	and	CCONJ
admet-2454	71	28	agilent	agilent	PROPN
admet-2454	71	29	technologies	technology	NOUN
admet-2454	71	30	1200	1200	NUM
admet-2454	71	31	series	series	NOUN
admet-2454	71	32	,	,	PUNCT
admet-2454	71	33	column	column	NOUN
admet-2454	71	34	:	:	PUNCT
admet-2454	71	35	zorbax	zorbax	PROPN
admet-2454	71	36	eclipse	eclipse	PROPN
admet-2454	71	37	plus	plus	CCONJ
admet-2454	71	38	(	(	PUNCT
admet-2454	71	39	c18	c18	NOUN
admet-2454	71	40	2.1×50	2.1×50	NUM
admet-2454	71	41	mm	mm	PROPN
admet-2454	71	42	,	,	PUNCT
admet-2454	71	43	3.5	3.5	NUM
admet-2454	71	44	µm	µm	NOUN
admet-2454	71	45	)	)	PUNCT
admet-2454	71	46	(	(	PUNCT
admet-2454	71	47	agilent	agilent	PROPN
admet-2454	71	48	technologies	technology	NOUN
admet-2454	71	49	)	)	PUNCT
admet-2454	71	50	,	,	PUNCT
admet-2454	71	51	flow	flow	NOUN
admet-2454	71	52	rate	rate	NOUN
admet-2454	71	53	:	:	PUNCT
admet-2454	71	54	0.6	0.6	NUM
admet-2454	71	55	ml	ml	NOUN
admet-2454	71	56	min-1	min-1	PROPN
admet-2454	71	57	,	,	PUNCT
admet-2454	71	58	mobile	mobile	ADJ
admet-2454	71	59	phase	phase	NOUN
admet-2454	71	60	:	:	PUNCT
admet-2454	71	61	0.1	0.1	NUM
admet-2454	71	62	%	%	NOUN
admet-2454	71	63	trifluoroacetic	trifluoroacetic	ADJ
admet-2454	71	64	acid	acid	NOUN
admet-2454	71	65	-	-	PUNCT
admet-2454	71	66	acetonitrile/0.1	acetonitrile/0.1	NUM
admet-2454	71	67	%	%	NOUN
admet-2454	71	68	trifluoroacetic	trifluoroacetic	ADJ
admet-2454	71	69	acid	acid	NOUN
admet-2454	71	70	-	-	PUNCT
admet-2454	71	71	water	water	NOUN
admet-2454	71	72	(	(	PUNCT
admet-2454	71	73	25	25	NUM
admet-2454	71	74	%	%	NOUN
admet-2454	71	75	(	(	PUNCT
admet-2454	71	76	bil	bil	NUM
admet-2454	71	77	)	)	PUNCT
admet-2454	71	78	,	,	PUNCT
admet-2454	71	79	35	35	NUM
admet-2454	71	80	%	%	NOUN
admet-2454	71	81	(	(	PUNCT
admet-2454	71	82	ctz	ctz	PROPN
admet-2454	71	83	)	)	PUNCT
admet-2454	71	84	,	,	PUNCT
admet-2454	71	85	35	35	NUM
admet-2454	71	86	%	%	NOUN
admet-2454	71	87	(	(	PUNCT
admet-2454	71	88	fex	fex	PROPN
admet-2454	71	89	)	)	PUNCT
admet-2454	71	90	,	,	PUNCT
admet-2454	71	91	and	and	CCONJ
admet-2454	71	92	28	28	NUM
admet-2454	71	93	%	%	NOUN
admet-2454	71	94	(	(	PUNCT
admet-2454	71	95	olo	olo	PROPN
admet-2454	71	96	)	)	PUNCT
admet-2454	71	97	)	)	PUNCT
admet-2454	71	98	,	,	PUNCT
admet-2454	71	99	detection	detection	NOUN
admet-2454	71	100	:	:	PUNCT
admet-2454	71	101	uv	uv	NOUN
admet-2454	71	102	(	(	PUNCT
admet-2454	71	103	bil	bil	NUM
admet-2454	71	104	:	:	PUNCT
admet-2454	71	105	280	280	NUM
admet-2454	71	106	nm	nm	PROPN
admet-2454	71	107	,	,	PUNCT
admet-2454	71	108	cet	cet	PROPN
admet-2454	71	109	:	:	PUNCT
admet-2454	71	110	230	230	NUM
admet-2454	71	111	nm	nm	NOUN
admet-2454	71	112	,	,	PUNCT
admet-2454	71	113	fex	fex	PROPN
admet-2454	71	114	:	:	PUNCT
admet-2454	71	115	225	225	NUM
admet-2454	71	116	nm	nm	NOUN
admet-2454	71	117	,	,	PUNCT
admet-2454	71	118	and	and	CCONJ
admet-2454	71	119	olo	olo	PROPN
admet-2454	71	120	:	:	PUNCT
admet-2454	71	121	300	300	NUM
admet-2454	71	122	nm	nm	NOUN
admet-2454	71	123	)	)	PUNCT
admet-2454	71	124	,	,	PUNCT
admet-2454	71	125	column	column	NOUN
admet-2454	71	126	temperature	temperature	NOUN
admet-2454	71	127	:	:	PUNCT
admet-2454	71	128	40	40	NUM
admet-2454	71	129	°	°	NOUN
admet-2454	71	130	c	c	VERB
admet-2454	71	131	,	,	PUNCT
admet-2454	71	132	and	and	CCONJ
admet-2454	71	133	injection	injection	NOUN
admet-2454	71	134	volume	volume	NOUN
admet-2454	71	135	of	of	ADP
admet-2454	71	136	10	10	NUM
admet-2454	71	137	µl	µl	NOUN
admet-2454	71	138	)	)	PUNCT
admet-2454	71	139	.	.	PUNCT
admet-2454	72	1	permeation	permeation	NOUN
admet-2454	72	2	was	be	AUX
admet-2454	72	3	calculated	calculate	VERB
admet-2454	72	4	as	as	ADP
admet-2454	72	5	the	the	DET
admet-2454	72	6	ratio	ratio	NOUN
admet-2454	72	7	of	of	ADP
admet-2454	72	8	the	the	DET
admet-2454	72	9	concentration	concentration	NOUN
admet-2454	72	10	in	in	ADP
admet-2454	72	11	the	the	DET
admet-2454	72	12	acceptor	acceptor	NOUN
admet-2454	72	13	side	side	NOUN
admet-2454	72	14	at	at	ADP
admet-2454	72	15	1	1	NUM
admet-2454	72	16	h	h	NOUN
admet-2454	72	17	and	and	CCONJ
admet-2454	72	18	the	the	DET
admet-2454	72	19	theoretical	theoretical	ADJ
admet-2454	72	20	equilibrium	equilibrium	NOUN
admet-2454	72	21	concentration	concentration	NOUN
admet-2454	72	22	(	(	PUNCT
admet-2454	72	23	0.02	0.02	NUM
admet-2454	72	24	mm	mm	NOUN
admet-2454	72	25	(	(	PUNCT
admet-2454	72	26	bil	bil	NUM
admet-2454	72	27	)	)	PUNCT
admet-2454	72	28	,	,	PUNCT
admet-2454	72	29	0.1	0.1	NUM
admet-2454	72	30	mm	mm	PROPN
admet-2454	72	31	(	(	PUNCT
admet-2454	72	32	ctz	ctz	PROPN
admet-2454	72	33	)	)	PUNCT
admet-2454	72	34	,	,	PUNCT
admet-2454	72	35	0.25	0.25	NUM
admet-2454	72	36	mm	mm	NOUN
admet-2454	72	37	(	(	PUNCT
admet-2454	72	38	fex	fex	PROPN
admet-2454	72	39	)	)	PUNCT
admet-2454	72	40	,	,	PUNCT
admet-2454	72	41	and	and	CCONJ
admet-2454	72	42	0.25	0.25	NUM
admet-2454	72	43	mm	mm	NOUN
admet-2454	72	44	(	(	PUNCT
admet-2454	72	45	olo	olo	PROPN
admet-2454	72	46	)	)	PUNCT
admet-2454	72	47	)	)	PUNCT
admet-2454	73	1	(	(	PUNCT
admet-2454	73	2	×100	×100	VERB
admet-2454	73	3	to	to	PART
admet-2454	73	4	convert	convert	VERB
admet-2454	73	5	to	to	ADP
admet-2454	73	6	%	%	NOUN
admet-2454	73	7	)	)	PUNCT
admet-2454	73	8	.	.	PUNCT
admet-2454	74	1	the	the	DET
admet-2454	74	2	unbound	unbound	NOUN
admet-2454	74	3	fraction	fraction	NOUN
admet-2454	74	4	(	(	PUNCT
admet-2454	74	5	fu	fu	NOUN
admet-2454	74	6	)	)	PUNCT
admet-2454	74	7	was	be	AUX
admet-2454	74	8	calculated	calculate	VERB
admet-2454	74	9	as	as	ADP
admet-2454	74	10	the	the	DET
admet-2454	74	11	ratio	ratio	NOUN
admet-2454	74	12	of	of	ADP
admet-2454	74	13	permeation	permeation	NOUN
admet-2454	74	14	in	in	ADP
admet-2454	74	15	each	each	DET
admet-2454	74	16	medium	medium	NOUN
admet-2454	74	17	and	and	CCONJ
admet-2454	74	18	the	the	DET
admet-2454	74	19	test	test	NOUN
admet-2454	74	20	medium	medium	NOUN
admet-2454	74	21	of	of	ADP
admet-2454	74	22	blank	blank	ADJ
admet-2454	74	23	fassif	fassif	NOUN
admet-2454	74	24	.	.	PUNCT
admet-2454	75	1	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	PROPN
admet-2454	75	2	r.	r.	PROPN
admet-2454	75	3	takeuchi	takeuchi	PROPN
admet-2454	75	4	and	and	CCONJ
admet-2454	75	5	k.	k.	PROPN
admet-2454	75	6	sugano	sugano	PROPN
admet-2454	75	7	admet	admet	PROPN
admet-2454	75	8	&	&	CCONJ
admet-2454	75	9	dmpk	dmpk	PROPN
admet-2454	75	10	12(4	12(4	PROPN
admet-2454	75	11	)	)	PUNCT
admet-2454	75	12	(	(	PUNCT
admet-2454	75	13	2024	2024	NUM
admet-2454	75	14	)	)	PUNCT
admet-2454	75	15	649	649	NUM
admet-2454	75	16	-	-	SYM
admet-2454	75	17	656	656	NUM
admet-2454	75	18	652	652	NUM
admet-2454	75	19	table	table	NOUN
admet-2454	75	20	2	2	NUM
admet-2454	75	21	.	.	PUNCT
admet-2454	75	22	composition	composition	NOUN
admet-2454	75	23	of	of	ADP
admet-2454	75	24	simulated	simulated	ADJ
admet-2454	75	25	intestinal	intestinal	ADJ
admet-2454	75	26	fluids	fluid	NOUN
admet-2454	75	27	a	a	DET
admet-2454	75	28	test	test	NOUN
admet-2454	75	29	medium	medium	NOUN
admet-2454	75	30	content	content	NOUN
admet-2454	75	31	,	,	PUNCT
admet-2454	75	32	mm	mm	PROPN
admet-2454	75	33	bfh	bfh	PROPN
admet-2454	75	34	,	,	PUNCT
admet-2454	75	35	%	%	INTJ
admet-2454	75	36	c	c	PROPN
admet-2454	76	1	tc	tc	INTJ
admet-2454	77	1	el	el	INTJ
admet-2454	77	2	gm	gm	PROPN
admet-2454	77	3	oa	oa	INTJ
admet-2454	77	4	fassif	fassif	VERB
admet-2454	77	5	3	3	NUM
admet-2454	77	6	0.75	0.75	NUM
admet-2454	77	7	0	0	NUM
admet-2454	77	8	0	0	NUM
admet-2454	77	9	0	0	NUM
admet-2454	77	10	fessif	fessif	NOUN
admet-2454	77	11	15	15	NUM
admet-2454	77	12	3.75	3.75	NUM
admet-2454	77	13	0	0	NUM
admet-2454	77	14	0	0	NUM
admet-2454	77	15	0	0	NUM
admet-2454	78	1	×2fessif	×2fessif	NOUN
admet-2454	78	2	30	30	NUM
admet-2454	78	3	7.50	7.50	NUM
admet-2454	78	4	0	0	NUM
admet-2454	78	5	0	0	NUM
admet-2454	78	6	0	0	NUM
admet-2454	78	7	fessifv2	fessifv2	NOUN
admet-2454	78	8	10	10	NUM
admet-2454	78	9	2.0	2.0	NUM
admet-2454	78	10	5	5	NUM
admet-2454	78	11	0.8	0.8	NUM
admet-2454	78	12	0	0	NUM
admet-2454	78	13	bfh	bfh	PROPN
admet-2454	78	14	b	b	PROPN
admet-2454	78	15	0	0	NUM
admet-2454	78	16	0	0	NUM
admet-2454	78	17	0	0	NUM
admet-2454	78	18	0	0	NUM
admet-2454	78	19	50	50	NUM
admet-2454	78	20	fessif+bfh	fessif+bfh	NOUN
admet-2454	78	21	15	15	NUM
admet-2454	78	22	3.75	3.75	NUM
admet-2454	78	23	0	0	NUM
admet-2454	78	24	0	0	NUM
admet-2454	78	25	50	50	NUM
admet-2454	78	26	a	a	DET
admet-2454	78	27	the	the	DET
admet-2454	78	28	components	component	NOUN
admet-2454	78	29	were	be	AUX
admet-2454	78	30	dissolved	dissolve	VERB
admet-2454	78	31	in	in	ADP
admet-2454	78	32	a	a	DET
admet-2454	78	33	phosphate	phosphate	ADJ
admet-2454	78	34	buffer	buffer	NOUN
admet-2454	78	35	(	(	PUNCT
admet-2454	78	36	phosphate	phosphate	VERB
admet-2454	78	37	28.6	28.6	NUM
admet-2454	78	38	mm	mm	NOUN
admet-2454	78	39	,	,	PUNCT
admet-2454	78	40	nacl	nacl	NOUN
admet-2454	78	41	106	106	NUM
admet-2454	78	42	mm	mm	NOUN
admet-2454	78	43	,	,	PUNCT
admet-2454	78	44	ph	ph	X
admet-2454	78	45	6.5	6.5	NUM
admet-2454	78	46	)	)	PUNCT
admet-2454	78	47	(	(	PUNCT
admet-2454	78	48	blank	blank	ADJ
admet-2454	78	49	fassif	fassif	NOUN
admet-2454	78	50	)	)	PUNCT
admet-2454	78	51	.	.	PUNCT
admet-2454	79	1	tc	tc	PRON
admet-2454	79	2	:	:	PUNCT
admet-2454	79	3	taurocholic	taurocholic	ADJ
admet-2454	79	4	acid	acid	PROPN
admet-2454	79	5	,	,	PUNCT
admet-2454	79	6	el	el	PROPN
admet-2454	79	7	:	:	PUNCT
admet-2454	79	8	egg	egg	NOUN
admet-2454	79	9	lecithin	lecithin	NOUN
admet-2454	79	10	,	,	PUNCT
admet-2454	79	11	gm	gm	PROPN
admet-2454	79	12	:	:	PUNCT
admet-2454	79	13	glyceryl	glyceryl	NOUN
admet-2454	79	14	mono	mono	NOUN
admet-2454	79	15	-	-	PUNCT
admet-2454	79	16	oleate	oleate	NOUN
admet-2454	79	17	,	,	PUNCT
admet-2454	79	18	oa	oa	PROPN
admet-2454	79	19	:	:	PUNCT
admet-2454	79	20	oleic	oleic	ADJ
admet-2454	79	21	acid	acid	PROPN
admet-2454	79	22	.	.	PUNCT
admet-2454	80	1	b	b	X
admet-2454	80	2	bfh	bfh	PROPN
admet-2454	80	3	added	add	VERB
admet-2454	80	4	to	to	ADP
admet-2454	80	5	blank	blank	ADJ
admet-2454	80	6	fassif	fassif	NOUN
admet-2454	80	7	.	.	PUNCT
admet-2454	81	1	c	c	AUX
admet-2454	81	2	wt.%	wt.%	VERB
admet-2454	81	3	the	the	DET
admet-2454	81	4	octanol	octanol	NOUN
admet-2454	81	5	-	-	PUNCT
admet-2454	81	6	water	water	NOUN
admet-2454	81	7	distribution	distribution	NOUN
admet-2454	81	8	coefficient	coefficient	NOUN
admet-2454	81	9	measurement	measurement	VERB
admet-2454	81	10	the	the	DET
admet-2454	81	11	octanol	octanol	NOUN
admet-2454	81	12	-	-	PUNCT
admet-2454	81	13	water	water	NOUN
admet-2454	81	14	distribution	distribution	NOUN
admet-2454	81	15	coefficient	coefficient	NOUN
admet-2454	81	16	(	(	PUNCT
admet-2454	81	17	log	log	PROPN
admet-2454	81	18	doct	doct	NOUN
admet-2454	81	19	)	)	PUNCT
admet-2454	81	20	values	value	NOUN
admet-2454	81	21	of	of	ADP
admet-2454	81	22	model	model	NOUN
admet-2454	81	23	drugs	drug	NOUN
admet-2454	81	24	were	be	AUX
admet-2454	81	25	measured	measure	VERB
admet-2454	81	26	by	by	ADP
admet-2454	81	27	the	the	DET
admet-2454	81	28	shakeflask	shakeflask	NOUN
admet-2454	81	29	method	method	NOUN
admet-2454	81	30	.	.	PUNCT
admet-2454	82	1	a	a	DET
admet-2454	82	2	model	model	NOUN
admet-2454	82	3	drug	drug	NOUN
admet-2454	82	4	was	be	AUX
admet-2454	82	5	dissolved	dissolve	VERB
admet-2454	82	6	in	in	ADP
admet-2454	82	7	blank	blank	ADJ
admet-2454	82	8	fassif	fassif	NOUN
admet-2454	82	9	pre	pre	VERB
admet-2454	82	10	-	-	VERB
admet-2454	82	11	saturated	saturated	ADJ
admet-2454	82	12	with	with	ADP
admet-2454	82	13	1	1	NUM
admet-2454	82	14	-	-	PUNCT
admet-2454	82	15	octanol	octanol	NOUN
admet-2454	82	16	(	(	PUNCT
admet-2454	82	17	bil	bil	NUM
admet-2454	82	18	:	:	SYM
admet-2454	82	19	0.1	0.1	NUM
admet-2454	82	20	mm	mm	NOUN
admet-2454	82	21	,	,	PUNCT
admet-2454	82	22	ctz	ctz	PROPN
admet-2454	82	23	:	:	PUNCT
admet-2454	82	24	1	1	NUM
admet-2454	82	25	mm	mm	PROPN
admet-2454	82	26	,	,	PUNCT
admet-2454	82	27	fex	fex	PROPN
admet-2454	82	28	:	:	PUNCT
admet-2454	82	29	1	1	NUM
admet-2454	82	30	mm	mm	NOUN
admet-2454	82	31	,	,	PUNCT
admet-2454	82	32	and	and	CCONJ
admet-2454	82	33	olo	olo	PROPN
admet-2454	82	34	:	:	PUNCT
admet-2454	82	35	1	1	NUM
admet-2454	82	36	mm	mm	NOUN
admet-2454	82	37	)	)	PUNCT
admet-2454	82	38	.	.	PUNCT
admet-2454	83	1	the	the	DET
admet-2454	83	2	drug	drug	NOUN
admet-2454	83	3	solution	solution	NOUN
admet-2454	83	4	(	(	PUNCT
admet-2454	83	5	2.5	2.5	NUM
admet-2454	83	6	ml	ml	NOUN
admet-2454	83	7	or	or	CCONJ
admet-2454	83	8	5.5	5.5	NUM
admet-2454	83	9	ml	ml	NOUN
admet-2454	83	10	)	)	PUNCT
admet-2454	83	11	was	be	AUX
admet-2454	83	12	added	add	VERB
admet-2454	83	13	to	to	ADP
admet-2454	83	14	0.5	0.5	NUM
admet-2454	83	15	ml	ml	NOUN
admet-2454	83	16	of	of	ADP
admet-2454	83	17	1	1	NUM
admet-2454	83	18	-	-	PUNCT
admet-2454	83	19	octanol	octanol	NOUN
admet-2454	83	20	presaturated	presaturate	VERB
admet-2454	83	21	with	with	ADP
admet-2454	83	22	water	water	NOUN
admet-2454	83	23	.	.	PUNCT
admet-2454	84	1	the	the	DET
admet-2454	84	2	samples	sample	NOUN
admet-2454	84	3	were	be	AUX
admet-2454	84	4	shaken	shake	VERB
admet-2454	84	5	by	by	ADP
admet-2454	84	6	a	a	DET
admet-2454	84	7	shaker	shaker	NOUN
admet-2454	84	8	for	for	ADP
admet-2454	84	9	90	90	NUM
admet-2454	84	10	minutes	minute	NOUN
admet-2454	84	11	at	at	ADP
admet-2454	84	12	room	room	NOUN
admet-2454	84	13	temperature	temperature	NOUN
admet-2454	84	14	(	(	PUNCT
admet-2454	84	15	25	25	NUM
admet-2454	84	16	±	±	NUM
admet-2454	84	17	2	2	NUM
admet-2454	84	18	°	°	ADP
admet-2454	84	19	c	c	NOUN
admet-2454	84	20	)	)	PUNCT
admet-2454	84	21	.	.	PUNCT
admet-2454	85	1	the	the	DET
admet-2454	85	2	drug	drug	NOUN
admet-2454	85	3	concentration	concentration	NOUN
admet-2454	85	4	in	in	ADP
admet-2454	85	5	the	the	DET
admet-2454	85	6	aqueous	aqueous	ADJ
admet-2454	85	7	phase	phase	NOUN
admet-2454	85	8	was	be	AUX
admet-2454	85	9	measured	measure	VERB
admet-2454	85	10	by	by	ADP
admet-2454	85	11	a	a	DET
admet-2454	85	12	uv	uv	NOUN
admet-2454	85	13	absorbance	absorbance	NOUN
admet-2454	85	14	(	(	PUNCT
admet-2454	85	15	bil	bil	NUM
admet-2454	85	16	:	:	PUNCT
admet-2454	85	17	280	280	NUM
admet-2454	85	18	nm	nm	PROPN
admet-2454	85	19	,	,	PUNCT
admet-2454	85	20	cet	cet	PROPN
admet-2454	85	21	:	:	PUNCT
admet-2454	85	22	230	230	NUM
admet-2454	85	23	nm	nm	NOUN
admet-2454	85	24	,	,	PUNCT
admet-2454	85	25	fex	fex	PROPN
admet-2454	85	26	:	:	PUNCT
admet-2454	85	27	225	225	NUM
admet-2454	85	28	nm	nm	NOUN
admet-2454	85	29	,	,	PUNCT
admet-2454	85	30	and	and	CCONJ
admet-2454	85	31	olo	olo	PROPN
admet-2454	85	32	:	:	PUNCT
admet-2454	85	33	300	300	NUM
admet-2454	85	34	nm	nm	NOUN
admet-2454	85	35	,	,	PUNCT
admet-2454	85	36	uv-1850	uv-1850	NOUN
admet-2454	85	37	,	,	PUNCT
admet-2454	85	38	shimadzu	shimadzu	ADJ
admet-2454	85	39	corporation	corporation	NOUN
admet-2454	85	40	,	,	PUNCT
admet-2454	85	41	kyoto	kyoto	PROPN
admet-2454	85	42	,	,	PUNCT
admet-2454	85	43	japan	japan	PROPN
admet-2454	85	44	)	)	PUNCT
admet-2454	85	45	.	.	PUNCT
admet-2454	86	1	the	the	DET
admet-2454	86	2	log	log	NOUN
admet-2454	86	3	doct	doct	PROPN
admet-2454	86	4	value	value	NOUN
admet-2454	86	5	was	be	AUX
admet-2454	86	6	calculated	calculate	VERB
admet-2454	86	7	by	by	ADP
admet-2454	86	8	equation	equation	NOUN
admet-2454	86	9	4	4	NUM
admet-2454	86	10	:	:	PUNCT
admet-2454	86	11	(	(	PUNCT
admet-2454	86	12	)	)	PUNCT
admet-2454	86	13	aq	aq	PROPN
admet-2454	86	14	,	,	PUNCT
admet-2454	86	15	ini	ini	PROPN
admet-2454	86	16	aq	aq	PROPN
admet-2454	86	17	aq	aq	PROPN
admet-2454	86	18	oct	oct	PROPN
admet-2454	86	19	aq	aq	PROPN
admet-2454	86	20	oct	oct	PROPN
admet-2454	86	21	  	  	SPACE
admet-2454	86	22	c	c	PROPN
admet-2454	86	23	c	c	NOUN
admet-2454	86	24	v	v	NOUN
admet-2454	86	25	d	d	X
admet-2454	86	26	c	c	NOUN
admet-2454	86	27	v	v	NOUN
admet-2454	86	28	−	−	PROPN
admet-2454	86	29	=	=	PUNCT
admet-2454	86	30	(	(	PUNCT
admet-2454	86	31	4	4	NUM
admet-2454	86	32	)	)	PUNCT
admet-2454	86	33	where	where	SCONJ
admet-2454	86	34	caq	caq	PROPN
admet-2454	86	35	,	,	PUNCT
admet-2454	86	36	ini	ini	PROPN
admet-2454	86	37	and	and	CCONJ
admet-2454	86	38	caq	caq	NOUN
admet-2454	86	39	are	be	AUX
admet-2454	86	40	the	the	DET
admet-2454	86	41	initial	initial	ADJ
admet-2454	86	42	and	and	CCONJ
admet-2454	86	43	equilibrium	equilibrium	NOUN
admet-2454	86	44	drug	drug	NOUN
admet-2454	86	45	concentrations	concentration	NOUN
admet-2454	86	46	in	in	ADP
admet-2454	86	47	the	the	DET
admet-2454	86	48	aqueous	aqueous	ADJ
admet-2454	86	49	phase	phase	NOUN
admet-2454	86	50	,	,	PUNCT
admet-2454	86	51	and	and	CCONJ
admet-2454	86	52	vaq	vaq	NOUN
admet-2454	86	53	and	and	CCONJ
admet-2454	86	54	voct	voct	NOUN
admet-2454	86	55	are	be	AUX
admet-2454	86	56	the	the	DET
admet-2454	86	57	volume	volume	NOUN
admet-2454	86	58	of	of	ADP
admet-2454	86	59	aqueous	aqueous	ADJ
admet-2454	86	60	and	and	CCONJ
admet-2454	86	61	octanol	octanol	NOUN
admet-2454	86	62	phases	phase	NOUN
admet-2454	86	63	,	,	PUNCT
admet-2454	86	64	respectively	respectively	ADV
admet-2454	86	65	.	.	PUNCT
admet-2454	87	1	results	result	NOUN
admet-2454	87	2	and	and	CCONJ
admet-2454	87	3	discussion	discussion	VERB
admet-2454	87	4	the	the	DET
admet-2454	87	5	fu	fu	ADJ
admet-2454	87	6	values	value	NOUN
admet-2454	87	7	of	of	ADP
admet-2454	87	8	all	all	DET
admet-2454	87	9	drugs	drug	NOUN
admet-2454	87	10	decreased	decrease	VERB
admet-2454	87	11	in	in	ADP
admet-2454	87	12	the	the	DET
admet-2454	87	13	presence	presence	NOUN
admet-2454	87	14	of	of	ADP
admet-2454	87	15	bile	bile	NOUN
admet-2454	87	16	micelles	micelle	NOUN
admet-2454	87	17	and	and	CCONJ
admet-2454	87	18	bfh	bfh	PROPN
admet-2454	87	19	(	(	PUNCT
admet-2454	87	20	figure	figure	NOUN
admet-2454	87	21	2	2	NUM
admet-2454	87	22	,	,	PUNCT
admet-2454	87	23	table	table	NOUN
admet-2454	87	24	3	3	NUM
admet-2454	87	25	)	)	PUNCT
admet-2454	87	26	.	.	PUNCT
admet-2454	88	1	this	this	DET
admet-2454	88	2	result	result	NOUN
admet-2454	88	3	suggests	suggest	VERB
admet-2454	88	4	that	that	SCONJ
admet-2454	88	5	the	the	DET
admet-2454	88	6	reduction	reduction	NOUN
admet-2454	88	7	of	of	ADP
admet-2454	88	8	fu	fu	NOUN
admet-2454	88	9	by	by	ADP
admet-2454	88	10	bile	bile	NOUN
admet-2454	88	11	micelle	micelle	NOUN
admet-2454	88	12	binding	bind	VERB
admet-2454	88	13	in	in	ADP
admet-2454	88	14	the	the	DET
admet-2454	88	15	fed	fed	PROPN
admet-2454	88	16	state	state	NOUN
admet-2454	88	17	is	be	AUX
admet-2454	88	18	likely	likely	ADJ
admet-2454	88	19	to	to	PART
admet-2454	88	20	be	be	AUX
admet-2454	88	21	one	one	NUM
admet-2454	88	22	of	of	ADP
admet-2454	88	23	the	the	DET
admet-2454	88	24	reasons	reason	NOUN
admet-2454	88	25	for	for	ADP
admet-2454	88	26	the	the	DET
admet-2454	88	27	negative	negative	ADJ
admet-2454	88	28	food	food	NOUN
admet-2454	88	29	effect	effect	NOUN
admet-2454	88	30	on	on	ADP
admet-2454	88	31	the	the	DET
admet-2454	88	32	oral	oral	ADJ
admet-2454	88	33	absorption	absorption	NOUN
admet-2454	88	34	of	of	ADP
admet-2454	88	35	these	these	DET
admet-2454	88	36	drugs	drug	NOUN
admet-2454	88	37	.	.	PUNCT
admet-2454	89	1	the	the	DET
admet-2454	89	2	addition	addition	NOUN
admet-2454	89	3	of	of	ADP
admet-2454	89	4	bfh	bfh	PROPN
admet-2454	89	5	also	also	ADV
admet-2454	89	6	decreased	decrease	VERB
admet-2454	89	7	the	the	DET
admet-2454	89	8	fu	fu	ADJ
admet-2454	89	9	values	value	NOUN
admet-2454	89	10	of	of	ADP
admet-2454	89	11	model	model	NOUN
admet-2454	89	12	drugs	drug	NOUN
admet-2454	89	13	.	.	PUNCT
admet-2454	90	1	therefore	therefore	ADV
admet-2454	90	2	,	,	PUNCT
admet-2454	90	3	direct	direct	ADJ
admet-2454	90	4	food	food	NOUN
admet-2454	90	5	binding	bind	VERB
admet-2454	90	6	could	could	AUX
admet-2454	90	7	also	also	ADV
admet-2454	90	8	be	be	AUX
admet-2454	90	9	one	one	NUM
admet-2454	90	10	of	of	ADP
admet-2454	90	11	the	the	DET
admet-2454	90	12	reasons	reason	NOUN
admet-2454	90	13	for	for	ADP
admet-2454	90	14	the	the	DET
admet-2454	90	15	negative	negative	ADJ
admet-2454	90	16	food	food	NOUN
admet-2454	90	17	effect	effect	NOUN
admet-2454	90	18	.	.	PUNCT
admet-2454	91	1	the	the	DET
admet-2454	91	2	fu	fu	PROPN
admet-2454	91	3	ratios	ratio	NOUN
admet-2454	91	4	of	of	ADP
admet-2454	91	5	fessif	fessif	NOUN
admet-2454	91	6	/	/	SYM
admet-2454	91	7	fassif	fassif	NOUN
admet-2454	91	8	of	of	ADP
admet-2454	91	9	fex	fex	PROPN
admet-2454	91	10	and	and	CCONJ
admet-2454	91	11	olo	olo	PROPN
admet-2454	91	12	were	be	AUX
admet-2454	91	13	in	in	ADP
admet-2454	91	14	good	good	ADJ
admet-2454	91	15	agreement	agreement	NOUN
admet-2454	91	16	with	with	ADP
admet-2454	91	17	the	the	DET
admet-2454	91	18	extent	extent	NOUN
admet-2454	91	19	of	of	ADP
admet-2454	91	20	the	the	DET
admet-2454	91	21	food	food	NOUN
admet-2454	91	22	effect	effect	NOUN
admet-2454	91	23	in	in	ADP
admet-2454	91	24	humans	human	NOUN
admet-2454	91	25	.	.	PUNCT
admet-2454	92	1	however	however	ADV
admet-2454	92	2	,	,	PUNCT
admet-2454	92	3	the	the	DET
admet-2454	92	4	food	food	NOUN
admet-2454	92	5	effect	effect	NOUN
admet-2454	92	6	was	be	AUX
admet-2454	92	7	underestimated	underestimate	VERB
admet-2454	92	8	for	for	ADP
admet-2454	92	9	bil	bil	NUM
admet-2454	92	10	and	and	CCONJ
admet-2454	92	11	overestimated	overestimate	VERB
admet-2454	92	12	for	for	ADP
admet-2454	92	13	cet	cet	PROPN
admet-2454	92	14	.	.	PUNCT
admet-2454	93	1	in	in	ADP
admet-2454	93	2	the	the	DET
admet-2454	93	3	presence	presence	NOUN
admet-2454	93	4	of	of	ADP
admet-2454	93	5	bfh	bfh	PROPN
admet-2454	93	6	,	,	PUNCT
admet-2454	93	7	the	the	DET
admet-2454	93	8	fu	fu	PROPN
admet-2454	93	9	ratio	ratio	NOUN
admet-2454	93	10	of	of	ADP
admet-2454	93	11	fessif	fessif	NOUN
admet-2454	93	12	/	/	SYM
admet-2454	93	13	fassif	fassif	NOUN
admet-2454	93	14	of	of	ADP
admet-2454	93	15	bil	bil	NUM
admet-2454	93	16	was	be	AUX
admet-2454	93	17	in	in	ADP
admet-2454	93	18	good	good	ADJ
admet-2454	93	19	agreement	agreement	NOUN
admet-2454	93	20	with	with	ADP
admet-2454	93	21	the	the	DET
admet-2454	93	22	food	food	NOUN
admet-2454	93	23	effect	effect	NOUN
admet-2454	93	24	.	.	PUNCT
admet-2454	94	1	even	even	ADV
admet-2454	94	2	though	though	SCONJ
admet-2454	94	3	the	the	DET
admet-2454	94	4	fu	fu	PROPN
admet-2454	94	5	ratio	ratio	NOUN
admet-2454	94	6	of	of	ADP
admet-2454	94	7	cet	cet	PROPN
admet-2454	94	8	is	be	AUX
admet-2454	94	9	lower	low	ADJ
admet-2454	94	10	than	than	ADP
admet-2454	94	11	that	that	PRON
admet-2454	94	12	of	of	ADP
admet-2454	94	13	the	the	DET
admet-2454	94	14	other	other	ADJ
admet-2454	94	15	drugs	drug	NOUN
admet-2454	94	16	,	,	PUNCT
admet-2454	94	17	the	the	DET
admet-2454	94	18	clinical	clinical	ADJ
admet-2454	94	19	negative	negative	ADJ
admet-2454	94	20	food	food	NOUN
admet-2454	94	21	effect	effect	NOUN
admet-2454	94	22	on	on	ADP
admet-2454	94	23	the	the	DET
admet-2454	94	24	oral	oral	ADJ
admet-2454	94	25	absorption	absorption	NOUN
admet-2454	94	26	of	of	ADP
admet-2454	94	27	cet	cet	PROPN
admet-2454	94	28	is	be	AUX
admet-2454	94	29	less	less	ADV
admet-2454	94	30	significant	significant	ADJ
admet-2454	94	31	.	.	PUNCT
admet-2454	95	1	this	this	PRON
admet-2454	95	2	would	would	AUX
admet-2454	95	3	be	be	AUX
admet-2454	95	4	due	due	ADJ
admet-2454	95	5	to	to	ADP
admet-2454	95	6	the	the	DET
admet-2454	95	7	higher	high	ADJ
admet-2454	95	8	lipophilicity	lipophilicity	NOUN
admet-2454	95	9	and	and	CCONJ
admet-2454	95	10	faster	fast	ADV
admet-2454	95	11	passive	passive	ADJ
admet-2454	95	12	permeability	permeability	NOUN
admet-2454	95	13	of	of	ADP
admet-2454	95	14	cet	cet	PROPN
admet-2454	95	15	.	.	PUNCT
admet-2454	96	1	in	in	ADP
admet-2454	96	2	such	such	ADJ
admet-2454	96	3	case	case	NOUN
admet-2454	96	4	,	,	PUNCT
admet-2454	96	5	the	the	DET
admet-2454	96	6	extent	extent	NOUN
admet-2454	96	7	of	of	ADP
admet-2454	96	8	fa	fa	PROPN
admet-2454	96	9	becomes	become	VERB
admet-2454	96	10	less	less	ADV
admet-2454	96	11	sensitive	sensitive	ADJ
admet-2454	96	12	to	to	ADP
admet-2454	96	13	a	a	DET
admet-2454	96	14	decrease	decrease	NOUN
admet-2454	96	15	in	in	ADP
admet-2454	96	16	fu	fu	NOUN
admet-2454	96	17	and	and	CCONJ
admet-2454	96	18	peff	peff	PROPN
admet-2454	96	19	(	(	PUNCT
admet-2454	96	20	eq	eq	NOUN
admet-2454	96	21	.	.	PROPN
admet-2454	96	22	3	3	NUM
admet-2454	96	23	)	)	PUNCT
admet-2454	96	24	.	.	PUNCT
admet-2454	97	1	the	the	DET
admet-2454	97	2	bioavailability	bioavailability	NOUN
admet-2454	97	3	in	in	ADP
admet-2454	97	4	humans	human	NOUN
admet-2454	97	5	of	of	ADP
admet-2454	97	6	cet	cet	PROPN
admet-2454	97	7	is	be	AUX
admet-2454	97	8	>	>	X
admet-2454	97	9	70	70	NUM
admet-2454	97	10	%	%	NOUN
admet-2454	98	1	[	[	X
admet-2454	98	2	11	11	NUM
admet-2454	98	3	]	]	PUNCT
admet-2454	98	4	,	,	PUNCT
admet-2454	98	5	which	which	PRON
admet-2454	98	6	is	be	AUX
admet-2454	98	7	higher	high	ADJ
admet-2454	98	8	than	than	ADP
admet-2454	98	9	that	that	PRON
admet-2454	98	10	of	of	ADP
admet-2454	98	11	fex	fex	PROPN
admet-2454	98	12	(	(	PUNCT
admet-2454	98	13	33	33	NUM
admet-2454	98	14	%	%	NOUN
admet-2454	98	15	)	)	PUNCT
admet-2454	99	1	[	[	X
admet-2454	99	2	16	16	NUM
admet-2454	99	3	]	]	PUNCT
admet-2454	99	4	and	and	CCONJ
admet-2454	99	5	bil	bil	NUM
admet-2454	99	6	(	(	PUNCT
admet-2454	99	7	61	61	NUM
admet-2454	99	8	%	%	NOUN
admet-2454	99	9	)	)	PUNCT
admet-2454	100	1	[	[	X
admet-2454	100	2	8	8	NUM
admet-2454	100	3	]	]	PUNCT
admet-2454	100	4	.	.	PUNCT
admet-2454	101	1	the	the	DET
admet-2454	101	2	charge	charge	NOUN
admet-2454	101	3	species	species	NOUN
admet-2454	101	4	distribution	distribution	NOUN
admet-2454	101	5	of	of	ADP
admet-2454	101	6	the	the	DET
admet-2454	101	7	model	model	NOUN
admet-2454	101	8	drugs	drug	NOUN
admet-2454	101	9	is	be	AUX
admet-2454	101	10	shown	show	VERB
admet-2454	101	11	in	in	ADP
admet-2454	101	12	figure	figure	NOUN
admet-2454	101	13	3	3	NUM
admet-2454	101	14	.	.	PUNCT
admet-2454	101	15	despite	despite	SCONJ
admet-2454	101	16	being	be	AUX
admet-2454	101	17	zwitterion	zwitterion	NOUN
admet-2454	101	18	at	at	ADP
admet-2454	101	19	ph	ph	PROPN
admet-2454	101	20	6.5	6.5	NUM
admet-2454	101	21	,	,	PUNCT
admet-2454	101	22	the	the	DET
admet-2454	101	23	antihistamine	antihistamine	NOUN
admet-2454	101	24	drugs	drug	NOUN
admet-2454	101	25	were	be	AUX
admet-2454	101	26	bound	bind	VERB
admet-2454	101	27	to	to	PART
admet-2454	101	28	bile	bile	NOUN
admet-2454	101	29	micelles	micelle	NOUN
admet-2454	101	30	.	.	PUNCT
admet-2454	102	1	the	the	DET
admet-2454	102	2	bile	bile	NOUN
admet-2454	102	3	micelle	micelle	NOUN
admet-2454	102	4	binding	bind	VERB
admet-2454	102	5	of	of	ADP
admet-2454	102	6	cet	cet	PROPN
admet-2454	102	7	was	be	AUX
admet-2454	102	8	stronger	strong	ADJ
admet-2454	102	9	than	than	ADP
admet-2454	102	10	that	that	PRON
admet-2454	102	11	of	of	ADP
admet-2454	102	12	others	other	NOUN
admet-2454	102	13	,	,	PUNCT
admet-2454	102	14	as	as	SCONJ
admet-2454	102	15	expected	expect	VERB
admet-2454	102	16	from	from	ADP
admet-2454	102	17	its	its	PRON
admet-2454	102	18	higher	high	ADJ
admet-2454	102	19	log	log	NOUN
admet-2454	102	20	doct	doct	PROPN
admet-2454	102	21	(	(	PUNCT
admet-2454	102	22	cet	cet	PROPN
admet-2454	102	23	>	>	X
admet-2454	102	24	fex	fex	PROPN
admet-2454	102	25	≈	≈	PROPN
admet-2454	102	26	bil	bil	PROPN
admet-2454	102	27	≈	≈	PROPN
admet-2454	102	28	olo	olo	PROPN
admet-2454	102	29	)	)	PUNCT
admet-2454	102	30	.	.	PUNCT
admet-2454	103	1	cet	cet	PROPN
admet-2454	103	2	is	be	AUX
admet-2454	103	3	a	a	DET
admet-2454	103	4	triprotic	triprotic	ADJ
admet-2454	103	5	compound	compound	NOUN
admet-2454	104	1	[	[	X
admet-2454	104	2	17,18	17,18	NUM
admet-2454	104	3	]	]	X
admet-2454	104	4	.	.	PUNCT
admet-2454	105	1	however	however	ADV
admet-2454	105	2	,	,	PUNCT
admet-2454	105	3	the	the	DET
admet-2454	105	4	first	first	ADJ
admet-2454	105	5	pka	pka	PROPN
admet-2454	105	6	(	(	PUNCT
admet-2454	105	7	n1	n1	PROPN
admet-2454	105	8	of	of	ADP
admet-2454	105	9	the	the	DET
admet-2454	105	10	piperidine	piperidine	NOUN
admet-2454	105	11	group	group	NOUN
admet-2454	105	12	)	)	PUNCT
admet-2454	105	13	is	be	AUX
admet-2454	105	14	2.12	2.12	NUM
admet-2454	105	15	and	and	CCONJ
admet-2454	105	16	is	be	AUX
admet-2454	105	17	not	not	PART
admet-2454	105	18	protonated	protonate	VERB
admet-2454	105	19	at	at	ADP
admet-2454	105	20	ph	ph	PROPN
admet-2454	105	21	6.5	6.5	NUM
admet-2454	105	22	.	.	PUNCT
admet-2454	106	1	therefore	therefore	ADV
admet-2454	106	2	,	,	PUNCT
admet-2454	106	3	cet	cet	PROPN
admet-2454	106	4	mainly	mainly	ADV
admet-2454	106	5	exists	exist	VERB
admet-2454	106	6	as	as	ADP
admet-2454	106	7	a	a	DET
admet-2454	106	8	zwitterion	zwitterion	NOUN
admet-2454	106	9	at	at	ADP
admet-2454	106	10	ph	ph	PROPN
admet-2454	106	11	6.5	6.5	NUM
admet-2454	106	12	.	.	PUNCT
admet-2454	107	1	admet	admet	PROPN
admet-2454	107	2	&	&	CCONJ
admet-2454	107	3	dmpk	dmpk	PROPN
admet-2454	107	4	12(4	12(4	PROPN
admet-2454	107	5	)	)	PUNCT
admet-2454	107	6	(	(	PUNCT
admet-2454	107	7	2024	2024	NUM
admet-2454	107	8	)	)	PUNCT
admet-2454	107	9	649	649	NUM
admet-2454	107	10	-	-	SYM
admet-2454	107	11	656	656	NUM
admet-2454	107	12	food	food	NOUN
admet-2454	107	13	and	and	CCONJ
admet-2454	107	14	bile	bile	NOUN
admet-2454	107	15	micelle	micelle	NOUN
admet-2454	107	16	binding	bind	VERB
admet-2454	107	17	of	of	ADP
admet-2454	107	18	zwitterionic	zwitterionic	ADJ
admet-2454	107	19	antihistamine	antihistamine	PROPN
admet-2454	107	20	drugs	drug	NOUN
admet-2454	107	21	doi	doi	PROPN
admet-2454	107	22	:	:	PUNCT
admet-2454	107	23	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	NOUN
admet-2454	107	24	653	653	NUM
admet-2454	107	25	figure	figure	NOUN
admet-2454	107	26	2	2	NUM
admet-2454	107	27	.	.	PUNCT
admet-2454	107	28	effect	effect	NOUN
admet-2454	107	29	of	of	ADP
admet-2454	107	30	bile	bile	NOUN
admet-2454	107	31	micelles	micelle	NOUN
admet-2454	107	32	and	and	CCONJ
admet-2454	107	33	fda	fda	PROPN
admet-2454	107	34	breakfast	breakfast	PROPN
admet-2454	107	35	homogenate	homogenate	NOUN
admet-2454	107	36	(	(	PUNCT
admet-2454	107	37	bfh	bfh	NOUN
admet-2454	107	38	)	)	PUNCT
admet-2454	107	39	on	on	ADP
admet-2454	107	40	the	the	DET
admet-2454	107	41	fu	fu	ADJ
admet-2454	107	42	values	value	NOUN
admet-2454	107	43	of	of	ADP
admet-2454	107	44	zwitterionic	zwitterionic	ADJ
admet-2454	107	45	antihistamine	antihistamine	NOUN
admet-2454	107	46	drugs	drug	NOUN
admet-2454	107	47	.	.	PUNCT
admet-2454	108	1	table	table	NOUN
admet-2454	108	2	3	3	NUM
admet-2454	108	3	.	.	X
admet-2454	108	4	permeation	permeation	NOUN
admet-2454	108	5	and	and	CCONJ
admet-2454	108	6	fu	fu	NOUN
admet-2454	108	7	a	a	DET
admet-2454	108	8	drug	drug	NOUN
admet-2454	108	9	test	test	NOUN
admet-2454	108	10	medium	medium	ADJ
admet-2454	108	11	permeation	permeation	NOUN
admet-2454	108	12	at	at	ADP
admet-2454	108	13	1	1	NUM
admet-2454	108	14	h	h	NOUN
admet-2454	108	15	,	,	PUNCT
admet-2454	108	16	%	%	NOUN
admet-2454	108	17	fu	fu	PROPN
admet-2454	108	18	fu	fu	PROPN
admet-2454	108	19	ratio	ratio	PROPN
admet-2454	108	20	b	b	PROPN
admet-2454	108	21	bilastine	bilastine	NOUN
admet-2454	109	1	blank	blank	ADJ
admet-2454	109	2	fassif	fassif	VERB
admet-2454	109	3	15.6	15.6	NUM
admet-2454	109	4	±	±	NUM
admet-2454	109	5	0.5	0.5	NUM
admet-2454	109	6	fassif	fassif	NOUN
admet-2454	109	7	17.3	17.3	NUM
admet-2454	109	8	±	±	NUM
admet-2454	110	1	0.8	0.8	NUM
admet-2454	110	2	1.10	1.10	NUM
admet-2454	110	3	±	±	NUM
admet-2454	110	4	0.05	0.05	NUM
admet-2454	110	5	fessif	fessif	NOUN
admet-2454	110	6	15.5	15.5	NUM
admet-2454	110	7	±	±	NUM
admet-2454	110	8	0.7	0.7	NUM
admet-2454	110	9	0.99	0.99	NUM
admet-2454	110	10	±	±	NUM
admet-2454	110	11	0.05	0.05	NUM
admet-2454	110	12	0.90	0.90	NUM
admet-2454	110	13	±	±	NUM
admet-2454	110	14	0.04	0.04	NUM
admet-2454	110	15	×2	×2	PROPN
admet-2454	110	16	fessif	fessif	VERB
admet-2454	110	17	12.1	12.1	NUM
admet-2454	110	18	±	±	NUM
admet-2454	110	19	0.6	0.6	NUM
admet-2454	110	20	0.78	0.78	NUM
admet-2454	110	21	±	±	NUM
admet-2454	110	22	0.04	0.04	NUM
admet-2454	110	23	0.70	0.70	NUM
admet-2454	110	24	±	±	NUM
admet-2454	110	25	0.03	0.03	NUM
admet-2454	110	26	fessif	fessif	NOUN
admet-2454	110	27	-	-	PUNCT
admet-2454	110	28	v2	v2	VERB
admet-2454	110	29	13.4	13.4	NUM
admet-2454	110	30	±	±	NUM
admet-2454	110	31	0.8	0.8	NUM
admet-2454	110	32	0.86	0.86	NUM
admet-2454	110	33	±	±	NUM
admet-2454	110	34	0.06	0.06	NUM
admet-2454	110	35	0.78	0.78	NUM
admet-2454	110	36	±	±	NUM
admet-2454	110	37	0.05	0.05	NUM
admet-2454	110	38	bfh	bfh	PROPN
admet-2454	110	39	9.0	9.0	NUM
admet-2454	110	40	±	±	NUM
admet-2454	110	41	0.1	0.1	NUM
admet-2454	110	42	0.58	0.58	NUM
admet-2454	110	43	±	±	NUM
admet-2454	110	44	0.00	0.00	NUM
admet-2454	110	45	0.52	0.52	NUM
admet-2454	110	46	±	±	NOUN
admet-2454	110	47	0.00	0.00	NUM
admet-2454	110	48	fessif+bfh	fessif+bfh	VERB
admet-2454	110	49	9.0	9.0	NUM
admet-2454	110	50	±	±	NUM
admet-2454	110	51	0.1	0.1	NUM
admet-2454	110	52	0.58	0.58	NUM
admet-2454	110	53	±	±	NUM
admet-2454	110	54	0.01	0.01	NUM
admet-2454	110	55	0.52	0.52	NUM
admet-2454	110	56	±	±	NUM
admet-2454	110	57	0.01	0.01	NUM
admet-2454	110	58	cetirizine	cetirizine	NOUN
admet-2454	110	59	blank	blank	NOUN
admet-2454	110	60	fassif	fassif	VERB
admet-2454	110	61	16.4	16.4	NUM
admet-2454	110	62	±	±	NOUN
admet-2454	110	63	0.6	0.6	NUM
admet-2454	110	64	fassif	fassif	VERB
admet-2454	110	65	16.3	16.3	NUM
admet-2454	110	66	±	±	NUM
admet-2454	110	67	0.5	0.5	NUM
admet-2454	110	68	0.99	0.99	NUM
admet-2454	110	69	±	±	NUM
admet-2454	110	70	0.03	0.03	NUM
admet-2454	110	71	fessif	fessif	VERB
admet-2454	110	72	7.4	7.4	NUM
admet-2454	110	73	±	±	NUM
admet-2454	110	74	0.2	0.2	NUM
admet-2454	110	75	0.45	0.45	NUM
admet-2454	110	76	±	±	NUM
admet-2454	110	77	0.01	0.01	NUM
admet-2454	110	78	0.46	0.46	NUM
admet-2454	110	79	±	±	NUM
admet-2454	111	1	0.01	0.01	NUM
admet-2454	111	2	×2	×2	PROPN
admet-2454	111	3	fessif	fessif	VERB
admet-2454	111	4	3.8	3.8	NUM
admet-2454	111	5	±	±	NUM
admet-2454	111	6	0.1	0.1	NUM
admet-2454	111	7	0.23	0.23	NUM
admet-2454	111	8	±	±	NUM
admet-2454	111	9	0.01	0.01	NUM
admet-2454	111	10	0.23	0.23	NUM
admet-2454	111	11	±	±	NUM
admet-2454	111	12	0.01	0.01	NUM
admet-2454	111	13	fessif	fessif	NOUN
admet-2454	111	14	-	-	PUNCT
admet-2454	111	15	v2	v2	VERB
admet-2454	111	16	8.7	8.7	NUM
admet-2454	111	17	±	±	NUM
admet-2454	111	18	0.1	0.1	NUM
admet-2454	111	19	0.53	0.53	NUM
admet-2454	111	20	±	±	NUM
admet-2454	111	21	0.00	0.00	NUM
admet-2454	111	22	0.53	0.53	NUM
admet-2454	111	23	±	±	NUM
admet-2454	111	24	0.00	0.00	NUM
admet-2454	111	25	bfh	bfh	PROPN
admet-2454	111	26	4.6	4.6	NUM
admet-2454	111	27	±	±	NUM
admet-2454	111	28	0.0	0.0	NUM
admet-2454	111	29	0.28	0.28	NUM
admet-2454	111	30	±	±	NUM
admet-2454	111	31	0.00	0.00	NUM
admet-2454	111	32	0.29	0.29	NUM
admet-2454	111	33	±	±	NOUN
admet-2454	111	34	0.00	0.00	NUM
admet-2454	111	35	fessif+bfh	fessif+bfh	VERB
admet-2454	111	36	3.5	3.5	NUM
admet-2454	111	37	±	±	NUM
admet-2454	111	38	0.2	0.2	NUM
admet-2454	111	39	0.21	0.21	NUM
admet-2454	111	40	±	±	NUM
admet-2454	111	41	0.01	0.01	NUM
admet-2454	111	42	0.22	0.22	NUM
admet-2454	111	43	±	±	NUM
admet-2454	111	44	0.01	0.01	NUM
admet-2454	111	45	fexofenadine	fexofenadine	NOUN
admet-2454	111	46	blank	blank	NOUN
admet-2454	111	47	fassif	fassif	VERB
admet-2454	111	48	12.0	12.0	NUM
admet-2454	111	49	±	±	NUM
admet-2454	112	1	0.7	0.7	NUM
admet-2454	112	2	fassif	fassif	NOUN
admet-2454	112	3	13.1	13.1	NUM
admet-2454	112	4	±	±	NUM
admet-2454	112	5	0.5	0.5	NUM
admet-2454	112	6	1.09	1.09	NUM
admet-2454	112	7	±	±	NUM
admet-2454	112	8	0.04	0.04	NUM
admet-2454	112	9	fessif	fessif	NOUN
admet-2454	112	10	10.0	10.0	NUM
admet-2454	112	11	±	±	NUM
admet-2454	112	12	0.7	0.7	NUM
admet-2454	112	13	0.84	0.84	NUM
admet-2454	112	14	±	±	NUM
admet-2454	112	15	0.06	0.06	NUM
admet-2454	112	16	0.76	0.76	NUM
admet-2454	112	17	±	±	NUM
admet-2454	112	18	0.06	0.06	NUM
admet-2454	113	1	×2	×2	PROPN
admet-2454	114	1	fessif	fessif	VERB
admet-2454	114	2	7.7	7.7	NUM
admet-2454	114	3	±	±	NUM
admet-2454	114	4	0.6	0.6	NUM
admet-2454	114	5	0.64	0.64	NUM
admet-2454	114	6	±	±	NUM
admet-2454	114	7	0.05	0.05	NUM
admet-2454	114	8	0.59	0.59	NUM
admet-2454	114	9	±	±	NUM
admet-2454	114	10	0.05	0.05	NUM
admet-2454	114	11	fessif	fessif	NOUN
admet-2454	114	12	-	-	PUNCT
admet-2454	114	13	v2	v2	VERB
admet-2454	114	14	10.6	10.6	NUM
admet-2454	114	15	±	±	NUM
admet-2454	114	16	0.4	0.4	NUM
admet-2454	114	17	0.88	0.88	NUM
admet-2454	114	18	±	±	NUM
admet-2454	114	19	0.03	0.03	NUM
admet-2454	114	20	0.81	0.81	NUM
admet-2454	114	21	±	±	NUM
admet-2454	114	22	0.03	0.03	NUM
admet-2454	114	23	bfh	bfh	PROPN
admet-2454	114	24	5.4	5.4	NUM
admet-2454	114	25	±	±	NUM
admet-2454	114	26	0.1	0.1	NUM
admet-2454	114	27	0.45	0.45	NUM
admet-2454	114	28	±	±	NUM
admet-2454	114	29	0.01	0.01	NUM
admet-2454	114	30	0.41	0.41	NUM
admet-2454	114	31	±	±	NOUN
admet-2454	114	32	0.01	0.01	NUM
admet-2454	114	33	fessif+bfh	fessif+bfh	VERB
admet-2454	114	34	5.1	5.1	NUM
admet-2454	114	35	±	±	NUM
admet-2454	114	36	0.1	0.1	NUM
admet-2454	114	37	0.43	0.43	NUM
admet-2454	114	38	±	±	NOUN
admet-2454	114	39	0.01	0.01	NUM
admet-2454	114	40	0.39	0.39	NUM
admet-2454	114	41	±	±	NUM
admet-2454	114	42	0.01	0.01	NUM
admet-2454	114	43	olopatadine	olopatadine	NOUN
admet-2454	114	44	blank	blank	ADJ
admet-2454	114	45	fassif	fassif	VERB
admet-2454	114	46	20.8	20.8	NUM
admet-2454	114	47	±	±	NUM
admet-2454	115	1	0.7	0.7	NUM
admet-2454	115	2	fassif	fassif	NOUN
admet-2454	115	3	21.9	21.9	NUM
admet-2454	115	4	±	±	NUM
admet-2454	115	5	0.5	0.5	NUM
admet-2454	115	6	1.05	1.05	NUM
admet-2454	115	7	±	±	NUM
admet-2454	115	8	0.02	0.02	NUM
admet-2454	115	9	fessif	fessif	NOUN
admet-2454	115	10	17.1	17.1	NUM
admet-2454	115	11	±	±	NUM
admet-2454	115	12	0.3	0.3	NUM
admet-2454	115	13	0.82	0.82	NUM
admet-2454	115	14	±	±	NUM
admet-2454	115	15	0.02	0.02	NUM
admet-2454	115	16	0.78	0.78	NUM
admet-2454	115	17	±	±	NUM
admet-2454	115	18	0.02	0.02	NUM
admet-2454	115	19	×2	×2	PROPN
admet-2454	115	20	fessif	fessif	VERB
admet-2454	115	21	12.2	12.2	NUM
admet-2454	115	22	±	±	NUM
admet-2454	115	23	0.1	0.1	NUM
admet-2454	115	24	0.59	0.59	NUM
admet-2454	115	25	±	±	NUM
admet-2454	115	26	0.01	0.01	NUM
admet-2454	115	27	0.56	0.56	NUM
admet-2454	115	28	±	±	NUM
admet-2454	115	29	0.01	0.01	NUM
admet-2454	115	30	fessif	fessif	NOUN
admet-2454	115	31	-	-	PUNCT
admet-2454	115	32	v2	v2	VERB
admet-2454	115	33	18.4	18.4	NUM
admet-2454	115	34	±	±	NUM
admet-2454	115	35	0.3	0.3	NUM
admet-2454	115	36	0.88	0.88	NUM
admet-2454	115	37	±	±	NUM
admet-2454	115	38	0.01	0.01	NUM
admet-2454	115	39	0.84	0.84	NUM
admet-2454	115	40	±	±	NUM
admet-2454	115	41	0.01	0.01	NUM
admet-2454	115	42	bfh	bfh	PROPN
admet-2454	115	43	10.3	10.3	NUM
admet-2454	115	44	±	±	NUM
admet-2454	115	45	0.3	0.3	NUM
admet-2454	115	46	0.50	0.50	NUM
admet-2454	115	47	±	±	NUM
admet-2454	115	48	0.02	0.02	NUM
admet-2454	115	49	0.47	0.47	NUM
admet-2454	115	50	±	±	NUM
admet-2454	115	51	0.01	0.01	NUM
admet-2454	115	52	fessif+bfh	fessif+bfh	VERB
admet-2454	115	53	9.7	9.7	NUM
admet-2454	115	54	±	±	NUM
admet-2454	115	55	0.2	0.2	NUM
admet-2454	115	56	0.46	0.46	NUM
admet-2454	115	57	±	±	NUM
admet-2454	115	58	0.01	0.01	NUM
admet-2454	115	59	0.44	0.44	NUM
admet-2454	115	60	±	±	NUM
admet-2454	115	61	0.01	0.01	NUM
admet-2454	115	62	amean	amean	PROPN
admet-2454	115	63	±	±	PROPN
admet-2454	115	64	s.d	s.d	PROPN
admet-2454	115	65	.	.	PROPN
admet-2454	115	66	,	,	PUNCT
admet-2454	115	67	n	n	PROPN
admet-2454	115	68	=	=	SYM
admet-2454	115	69	3	3	NUM
admet-2454	115	70	bvs	bvs	NOUN
admet-2454	115	71	.	.	PUNCT
admet-2454	116	1	the	the	DET
admet-2454	116	2	fu	fu	PROPN
admet-2454	116	3	value	value	NOUN
admet-2454	116	4	in	in	ADP
admet-2454	116	5	fassif	fassif	PROPN
admet-2454	116	6	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	PROPN
admet-2454	116	7	r.	r.	PROPN
admet-2454	116	8	takeuchi	takeuchi	PROPN
admet-2454	116	9	and	and	CCONJ
admet-2454	116	10	k.	k.	PROPN
admet-2454	116	11	sugano	sugano	PROPN
admet-2454	116	12	admet	admet	PROPN
admet-2454	116	13	&	&	CCONJ
admet-2454	116	14	dmpk	dmpk	PROPN
admet-2454	116	15	12(4	12(4	PROPN
admet-2454	116	16	)	)	PUNCT
admet-2454	116	17	(	(	PUNCT
admet-2454	116	18	2024	2024	NUM
admet-2454	116	19	)	)	PUNCT
admet-2454	116	20	649	649	NUM
admet-2454	116	21	-	-	SYM
admet-2454	116	22	656	656	NUM
admet-2454	116	23	654	654	NUM
admet-2454	116	24	the	the	DET
admet-2454	116	25	log	log	NOUN
admet-2454	116	26	doct	doct	NOUN
admet-2454	116	27	values	value	NOUN
admet-2454	116	28	of	of	ADP
admet-2454	116	29	bil	bil	NUM
admet-2454	116	30	(	(	PUNCT
admet-2454	116	31	0.39	0.39	NUM
admet-2454	116	32	)	)	PUNCT
admet-2454	116	33	and	and	CCONJ
admet-2454	116	34	olo	olo	PROPN
admet-2454	116	35	(	(	PUNCT
admet-2454	116	36	0.34	0.34	NUM
admet-2454	116	37	)	)	PUNCT
admet-2454	116	38	are	be	AUX
admet-2454	116	39	close	close	ADJ
admet-2454	116	40	to	to	ADP
admet-2454	116	41	that	that	PRON
admet-2454	116	42	of	of	ADP
admet-2454	116	43	propranolol	propranolol	NOUN
admet-2454	116	44	(	(	PUNCT
admet-2454	116	45	pro	pro	ADJ
admet-2454	116	46	)	)	PUNCT
admet-2454	116	47	(	(	PUNCT
admet-2454	116	48	log	log	VERB
admet-2454	116	49	doct	doct	NOUN
admet-2454	116	50	=	=	NOUN
admet-2454	116	51	0.4	0.4	NUM
admet-2454	116	52	)	)	PUNCT
admet-2454	117	1	[	[	X
admet-2454	117	2	5	5	NUM
admet-2454	117	3	]	]	PUNCT
admet-2454	117	4	.	.	PUNCT
admet-2454	118	1	in	in	ADP
admet-2454	118	2	addition	addition	NOUN
admet-2454	118	3	,	,	PUNCT
admet-2454	118	4	the	the	DET
admet-2454	118	5	amine	amine	ADJ
admet-2454	118	6	groups	group	NOUN
admet-2454	118	7	of	of	ADP
admet-2454	118	8	these	these	DET
admet-2454	118	9	drugs	drug	NOUN
admet-2454	118	10	are	be	AUX
admet-2454	118	11	>	>	X
admet-2454	118	12	99	99	NUM
admet-2454	118	13	%	%	NOUN
admet-2454	118	14	charged	charge	VERB
admet-2454	118	15	at	at	ADP
admet-2454	118	16	ph	ph	PROPN
admet-2454	118	17	6.5	6.5	NUM
admet-2454	118	18	.	.	PUNCT
admet-2454	119	1	however	however	ADV
admet-2454	119	2	,	,	PUNCT
admet-2454	119	3	the	the	DET
admet-2454	119	4	bile	bile	NOUN
admet-2454	119	5	micelle	micelle	NOUN
admet-2454	119	6	binding	bind	VERB
admet-2454	119	7	of	of	ADP
admet-2454	119	8	propranolol	propranolol	NOUN
admet-2454	119	9	is	be	AUX
admet-2454	119	10	reported	report	VERB
admet-2454	119	11	to	to	PART
admet-2454	119	12	be	be	AUX
admet-2454	119	13	about	about	ADV
admet-2454	119	14	3	3	NOUN
admet-2454	119	15	-	-	NOUN
admet-2454	119	16	fold	fold	VERB
admet-2454	119	17	stronger	strong	ADJ
admet-2454	119	18	than	than	ADP
admet-2454	119	19	those	those	PRON
admet-2454	119	20	of	of	ADP
admet-2454	119	21	bil	bil	NUM
admet-2454	119	22	and	and	CCONJ
admet-2454	119	23	olo	olo	PROPN
admet-2454	119	24	.	.	PUNCT
admet-2454	120	1	in	in	ADP
admet-2454	120	2	addition	addition	NOUN
admet-2454	120	3	,	,	PUNCT
admet-2454	120	4	even	even	ADV
admet-2454	120	5	though	though	SCONJ
admet-2454	120	6	the	the	DET
admet-2454	120	7	log	log	NOUN
admet-2454	120	8	doct	doct	NOUN
admet-2454	120	9	values	value	NOUN
admet-2454	120	10	of	of	ADP
admet-2454	120	11	the	the	DET
admet-2454	120	12	zwitterions	zwitterion	NOUN
admet-2454	120	13	are	be	AUX
admet-2454	120	14	greater	great	ADJ
admet-2454	120	15	than	than	ADP
admet-2454	120	16	that	that	PRON
admet-2454	120	17	of	of	ADP
admet-2454	120	18	quaternary	quaternary	ADJ
admet-2454	120	19	ammonium	ammonium	NOUN
admet-2454	120	20	compounds	compound	NOUN
admet-2454	120	21	(	(	PUNCT
admet-2454	120	22	qac	qac	NOUN
admet-2454	120	23	)	)	PUNCT
admet-2454	120	24	(	(	PUNCT
admet-2454	120	25	log	log	VERB
admet-2454	120	26	doct	doct	NOUN
admet-2454	120	27	<	<	X
admet-2454	120	28	<	<	X
admet-2454	120	29	0	0	NUM
admet-2454	120	30	)	)	PUNCT
admet-2454	120	31	,	,	PUNCT
admet-2454	120	32	the	the	DET
admet-2454	120	33	fu	fu	ADJ
admet-2454	120	34	values	value	NOUN
admet-2454	120	35	of	of	ADP
admet-2454	120	36	the	the	DET
admet-2454	120	37	zwitterionic	zwitterionic	ADJ
admet-2454	120	38	drugs	drug	NOUN
admet-2454	120	39	are	be	AUX
admet-2454	120	40	comparable	comparable	ADJ
admet-2454	120	41	with	with	ADP
admet-2454	120	42	that	that	PRON
admet-2454	120	43	of	of	ADP
admet-2454	120	44	qacs	qac	NOUN
admet-2454	120	45	[	[	X
admet-2454	120	46	7	7	NUM
admet-2454	120	47	]	]	PUNCT
admet-2454	120	48	.	.	PUNCT
admet-2454	121	1	the	the	DET
admet-2454	121	2	bile	bile	NOUN
admet-2454	121	3	micelles	micelle	NOUN
admet-2454	121	4	in	in	ADP
admet-2454	121	5	fassif	fassif	NOUN
admet-2454	121	6	and	and	CCONJ
admet-2454	121	7	fessif	fessif	NOUN
admet-2454	121	8	are	be	AUX
admet-2454	121	9	negatively	negatively	ADV
admet-2454	121	10	charged	charge	VERB
admet-2454	121	11	by	by	ADP
admet-2454	121	12	the	the	DET
admet-2454	121	13	-so3	-so3	PROPN
admet-2454	121	14	group	group	NOUN
admet-2454	121	15	in	in	ADP
admet-2454	121	16	taurocholic	taurocholic	ADJ
admet-2454	121	17	acid	acid	NOUN
admet-2454	121	18	.	.	PUNCT
admet-2454	122	1	therefore	therefore	ADV
admet-2454	122	2	,	,	PUNCT
admet-2454	122	3	the	the	DET
admet-2454	122	4	carboxyl	carboxyl	NOUN
admet-2454	122	5	anion	anion	NOUN
admet-2454	122	6	(	(	PUNCT
admet-2454	122	7	-coo-	-coo-	PUNCT
admet-2454	122	8	)	)	PUNCT
admet-2454	122	9	in	in	ADP
admet-2454	122	10	the	the	DET
admet-2454	122	11	zwitterionic	zwitterionic	ADJ
admet-2454	122	12	drugs	drug	NOUN
admet-2454	122	13	was	be	AUX
admet-2454	122	14	suggested	suggest	VERB
admet-2454	122	15	to	to	PART
admet-2454	122	16	reduce	reduce	VERB
admet-2454	122	17	the	the	DET
admet-2454	122	18	bile	bile	NOUN
admet-2454	122	19	micelle	micelle	NOUN
admet-2454	122	20	binding	bind	VERB
admet-2454	122	21	,	,	PUNCT
admet-2454	122	22	like	like	ADP
admet-2454	122	23	in	in	ADP
admet-2454	122	24	the	the	DET
admet-2454	122	25	cases	case	NOUN
admet-2454	122	26	of	of	ADP
admet-2454	122	27	liposome	liposome	NOUN
admet-2454	122	28	binding	bind	VERB
admet-2454	122	29	[	[	X
admet-2454	122	30	18,19	18,19	NUM
admet-2454	122	31	]	]	PUNCT
admet-2454	122	32	.	.	PUNCT
admet-2454	123	1	in	in	ADP
admet-2454	123	2	a	a	DET
admet-2454	123	3	buffer	buffer	NOUN
admet-2454	123	4	solution	solution	NOUN
admet-2454	123	5	at	at	ADP
admet-2454	123	6	the	the	DET
admet-2454	123	7	isoelectric	isoelectric	ADJ
admet-2454	123	8	ph	ph	NOUN
admet-2454	123	9	point	point	NOUN
admet-2454	123	10	,	,	PUNCT
admet-2454	123	11	a	a	DET
admet-2454	123	12	zwitterion	zwitterion	NOUN
admet-2454	123	13	drug	drug	NOUN
admet-2454	123	14	exists	exist	VERB
admet-2454	123	15	as	as	ADP
admet-2454	123	16	an	an	DET
admet-2454	123	17	equilibrium	equilibrium	NOUN
admet-2454	123	18	between	between	ADP
admet-2454	123	19	a	a	DET
admet-2454	123	20	zwitterion	zwitterion	NOUN
admet-2454	123	21	molecule	molecule	NOUN
admet-2454	123	22	and	and	CCONJ
admet-2454	123	23	an	an	DET
admet-2454	123	24	un	un	ADJ
admet-2454	123	25	-	-	ADJ
admet-2454	123	26	ionized	ionized	ADJ
admet-2454	123	27	molecule	molecule	NOUN
admet-2454	123	28	[	[	X
admet-2454	123	29	20	20	NUM
admet-2454	123	30	]	]	PUNCT
admet-2454	123	31	.	.	PUNCT
admet-2454	124	1	the	the	DET
admet-2454	124	2	isoelectric	isoelectric	ADJ
admet-2454	124	3	ph	ph	ADJ
admet-2454	124	4	points	point	NOUN
admet-2454	124	5	of	of	ADP
admet-2454	124	6	the	the	DET
admet-2454	124	7	model	model	NOUN
admet-2454	124	8	drugs	drug	NOUN
admet-2454	124	9	are	be	AUX
admet-2454	124	10	near	near	ADP
admet-2454	124	11	ph	ph	ADJ
admet-2454	124	12	6.5	6.5	NUM
admet-2454	124	13	(	(	PUNCT
admet-2454	124	14	5.4	5.4	NUM
admet-2454	124	15	to	to	PART
admet-2454	124	16	7.0	7.0	NUM
admet-2454	124	17	)	)	PUNCT
admet-2454	124	18	(	(	PUNCT
admet-2454	124	19	table	table	NOUN
admet-2454	124	20	1	1	NUM
admet-2454	124	21	)	)	PUNCT
admet-2454	124	22	.	.	PUNCT
admet-2454	125	1	from	from	ADP
admet-2454	125	2	the	the	DET
admet-2454	125	3	difference	difference	NOUN
admet-2454	125	4	between	between	ADP
admet-2454	125	5	the	the	DET
admet-2454	125	6	pka	pka	PROPN
admet-2454	125	7	values	value	NOUN
admet-2454	125	8	of	of	ADP
admet-2454	125	9	carboxylic	carboxylic	ADJ
admet-2454	125	10	acid	acid	NOUN
admet-2454	125	11	and	and	CCONJ
admet-2454	125	12	amine	amine	NOUN
admet-2454	125	13	(	(	PUNCT
admet-2454	125	14	>	>	X
admet-2454	125	15	3.6	3.6	NUM
admet-2454	125	16	)	)	PUNCT
admet-2454	125	17	,	,	PUNCT
admet-2454	125	18	they	they	PRON
admet-2454	125	19	are	be	AUX
admet-2454	125	20	estimated	estimate	VERB
admet-2454	125	21	to	to	PART
admet-2454	125	22	exist	exist	VERB
admet-2454	125	23	as	as	ADP
admet-2454	125	24	the	the	DET
admet-2454	125	25	zwitterion	zwitterion	NOUN
admet-2454	125	26	more	more	ADJ
admet-2454	125	27	than	than	ADP
admet-2454	125	28	99.8	99.8	NUM
admet-2454	125	29	%	%	NOUN
admet-2454	126	1	[	[	X
admet-2454	126	2	21	21	NUM
admet-2454	126	3	]	]	PUNCT
admet-2454	126	4	.	.	PUNCT
admet-2454	127	1	therefore	therefore	ADV
admet-2454	127	2	,	,	PUNCT
admet-2454	127	3	the	the	DET
admet-2454	127	4	zwitterionic	zwitterionic	ADJ
admet-2454	127	5	molecules	molecule	NOUN
admet-2454	127	6	may	may	AUX
admet-2454	127	7	bind	bind	VERB
admet-2454	127	8	bile	bile	NOUN
admet-2454	127	9	micelles	micelle	NOUN
admet-2454	127	10	.	.	PUNCT
admet-2454	128	1	a	a	DET
admet-2454	128	2	more	more	ADV
admet-2454	128	3	detailed	detailed	ADJ
admet-2454	128	4	mechanism	mechanism	NOUN
admet-2454	128	5	of	of	ADP
admet-2454	128	6	the	the	DET
admet-2454	128	7	charge	charge	NOUN
admet-2454	128	8	effect	effect	NOUN
admet-2454	128	9	on	on	ADP
admet-2454	128	10	the	the	DET
admet-2454	128	11	bile	bile	NOUN
admet-2454	128	12	micelle	micelle	NOUN
admet-2454	128	13	binding	bind	VERB
admet-2454	128	14	of	of	ADP
admet-2454	128	15	drugs	drug	NOUN
admet-2454	128	16	is	be	AUX
admet-2454	128	17	under	under	ADP
admet-2454	128	18	investigation	investigation	NOUN
admet-2454	128	19	.	.	PUNCT
admet-2454	129	1	figure	figure	NOUN
admet-2454	129	2	3	3	NUM
admet-2454	129	3	.	.	PUNCT
admet-2454	129	4	charge	charge	NOUN
admet-2454	129	5	species	specie	NOUN
admet-2454	129	6	distribution	distribution	NOUN
admet-2454	129	7	of	of	ADP
admet-2454	129	8	zwitterionic	zwitterionic	ADJ
admet-2454	129	9	antihistamine	antihistamine	PROPN
admet-2454	129	10	drugs	drug	NOUN
admet-2454	129	11	conclusions	conclusion	NOUN
admet-2454	129	12	in	in	ADP
admet-2454	129	13	conclusion	conclusion	NOUN
admet-2454	129	14	,	,	PUNCT
admet-2454	129	15	the	the	DET
admet-2454	129	16	zwitterionic	zwitterionic	ADJ
admet-2454	129	17	antihistamine	antihistamine	NOUN
admet-2454	129	18	drugs	drug	NOUN
admet-2454	129	19	were	be	AUX
admet-2454	129	20	found	find	VERB
admet-2454	129	21	to	to	PART
admet-2454	129	22	bind	bind	VERB
admet-2454	129	23	to	to	ADP
admet-2454	129	24	bile	bile	NOUN
admet-2454	129	25	micelles	micelle	NOUN
admet-2454	129	26	and	and	CCONJ
admet-2454	129	27	foods	food	NOUN
admet-2454	129	28	,	,	PUNCT
admet-2454	129	29	suggesting	suggest	VERB
admet-2454	129	30	that	that	SCONJ
admet-2454	129	31	it	it	PRON
admet-2454	129	32	would	would	AUX
admet-2454	129	33	be	be	AUX
admet-2454	129	34	the	the	DET
admet-2454	129	35	reason	reason	NOUN
admet-2454	129	36	for	for	ADP
admet-2454	129	37	the	the	DET
admet-2454	129	38	negative	negative	ADJ
admet-2454	129	39	food	food	NOUN
admet-2454	129	40	effect	effect	NOUN
admet-2454	129	41	.	.	PUNCT
admet-2454	130	1	the	the	DET
admet-2454	130	2	lipophilicity	lipophilicity	NOUN
admet-2454	130	3	and	and	CCONJ
admet-2454	130	4	charge	charge	NOUN
admet-2454	130	5	state	state	NOUN
admet-2454	130	6	were	be	AUX
admet-2454	130	7	suggested	suggest	VERB
admet-2454	130	8	to	to	PART
admet-2454	130	9	affect	affect	VERB
admet-2454	130	10	the	the	DET
admet-2454	130	11	bile	bile	NOUN
admet-2454	130	12	micelle	micelle	NOUN
admet-2454	130	13	binding	bind	VERB
admet-2454	130	14	.	.	PUNCT
admet-2454	131	1	dynamic	dynamic	ADJ
admet-2454	131	2	dialysis	dialysis	NOUN
admet-2454	131	3	would	would	AUX
admet-2454	131	4	be	be	AUX
admet-2454	131	5	a	a	DET
admet-2454	131	6	good	good	ADJ
admet-2454	131	7	tool	tool	NOUN
admet-2454	131	8	to	to	PART
admet-2454	131	9	measure	measure	VERB
admet-2454	131	10	bile	bile	NOUN
admet-2454	131	11	micelle	micelle	NOUN
admet-2454	131	12	and	and	CCONJ
admet-2454	131	13	food	food	NOUN
admet-2454	131	14	binding	bind	VERB
admet-2454	131	15	.	.	PUNCT
admet-2454	132	1	funding	funding	NOUN
admet-2454	132	2	:	:	PUNCT
admet-2454	132	3	no	no	DET
admet-2454	132	4	funding	funding	NOUN
admet-2454	132	5	support	support	NOUN
admet-2454	132	6	conflict	conflict	NOUN
admet-2454	132	7	of	of	ADP
admet-2454	132	8	interest	interest	NOUN
admet-2454	132	9	:	:	PUNCT
admet-2454	132	10	the	the	DET
admet-2454	132	11	author(s	author(s	PROPN
admet-2454	132	12	)	)	PUNCT
admet-2454	132	13	declare(s	declare(s	PROPN
admet-2454	132	14	)	)	PUNCT
admet-2454	132	15	that	that	SCONJ
admet-2454	132	16	they	they	PRON
admet-2454	132	17	have	have	VERB
admet-2454	132	18	no	no	DET
admet-2454	132	19	conflicts	conflict	NOUN
admet-2454	132	20	of	of	ADP
admet-2454	132	21	interest	interest	NOUN
admet-2454	132	22	to	to	PART
admet-2454	132	23	disclose	disclose	VERB
admet-2454	132	24	.	.	PUNCT
admet-2454	133	1	author	author	NOUN
admet-2454	133	2	contributions	contribution	NOUN
admet-2454	133	3	:	:	PUNCT
admet-2454	133	4	material	material	NOUN
admet-2454	133	5	preparation	preparation	NOUN
admet-2454	133	6	,	,	PUNCT
admet-2454	133	7	data	datum	NOUN
admet-2454	133	8	collection	collection	NOUN
admet-2454	133	9	and	and	CCONJ
admet-2454	133	10	analysis	analysis	NOUN
admet-2454	133	11	were	be	AUX
admet-2454	133	12	performed	perform	VERB
admet-2454	133	13	by	by	ADP
admet-2454	133	14	rie	rie	PROPN
admet-2454	133	15	takeuchi	takeuchi	PROPN
admet-2454	133	16	.	.	PUNCT
admet-2454	134	1	kiyohiko	kiyohiko	PROPN
admet-2454	134	2	sugano	sugano	PROPN
admet-2454	134	3	supervised	supervise	VERB
admet-2454	134	4	all	all	DET
admet-2454	134	5	phases	phase	NOUN
admet-2454	134	6	of	of	ADP
admet-2454	134	7	the	the	DET
admet-2454	134	8	study	study	NOUN
admet-2454	134	9	,	,	PUNCT
admet-2454	134	10	including	include	VERB
admet-2454	134	11	the	the	DET
admet-2454	134	12	manuscript	manuscript	NOUN
admet-2454	134	13	writing	writing	NOUN
admet-2454	134	14	.	.	PUNCT
admet-2454	135	1	all	all	DET
admet-2454	135	2	authors	author	NOUN
admet-2454	135	3	read	read	VERB
admet-2454	135	4	and	and	CCONJ
admet-2454	135	5	approved	approve	VERB
admet-2454	135	6	the	the	DET
admet-2454	135	7	final	final	ADJ
admet-2454	135	8	manuscript	manuscript	NOUN
admet-2454	135	9	.	.	PUNCT
admet-2454	136	1	admet	admet	PROPN
admet-2454	136	2	&	&	CCONJ
admet-2454	136	3	dmpk	dmpk	PROPN
admet-2454	136	4	12(4	12(4	PROPN
admet-2454	136	5	)	)	PUNCT
admet-2454	136	6	(	(	PUNCT
admet-2454	136	7	2024	2024	NUM
admet-2454	136	8	)	)	PUNCT
admet-2454	136	9	649	649	NUM
admet-2454	136	10	-	-	SYM
admet-2454	136	11	656	656	NUM
admet-2454	136	12	food	food	NOUN
admet-2454	136	13	and	and	CCONJ
admet-2454	136	14	bile	bile	NOUN
admet-2454	136	15	micelle	micelle	NOUN
admet-2454	136	16	binding	bind	VERB
admet-2454	136	17	of	of	ADP
admet-2454	136	18	zwitterionic	zwitterionic	ADJ
admet-2454	136	19	antihistamine	antihistamine	PROPN
admet-2454	136	20	drugs	drug	NOUN
admet-2454	136	21	doi	doi	PROPN
admet-2454	136	22	:	:	PUNCT
admet-2454	136	23	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	NOUN
admet-2454	136	24	655	655	NUM
admet-2454	136	25	data	datum	NOUN
admet-2454	136	26	availability	availability	NOUN
admet-2454	136	27	:	:	PUNCT
admet-2454	136	28	the	the	DET
admet-2454	136	29	datasets	dataset	NOUN
admet-2454	136	30	generated	generate	VERB
admet-2454	136	31	during	during	ADP
admet-2454	136	32	and/or	and/or	CCONJ
admet-2454	136	33	analysed	analyse	VERB
admet-2454	136	34	during	during	ADP
admet-2454	136	35	the	the	DET
admet-2454	136	36	current	current	ADJ
admet-2454	136	37	study	study	NOUN
admet-2454	136	38	are	be	AUX
admet-2454	136	39	available	available	ADJ
admet-2454	136	40	from	from	ADP
admet-2454	136	41	the	the	DET
admet-2454	136	42	corresponding	corresponding	ADJ
admet-2454	136	43	author	author	NOUN
admet-2454	136	44	on	on	ADP
admet-2454	136	45	request	request	NOUN
admet-2454	136	46	.	.	PUNCT
admet-2454	137	1	references	reference	NOUN
admet-2454	137	2	[	[	X
admet-2454	137	3	1	1	X
admet-2454	137	4	]	]	X
admet-2454	137	5	d.m	d.m	PROPN
admet-2454	137	6	.	.	PROPN
admet-2454	137	7	mudie	mudie	PROPN
admet-2454	137	8	,	,	PUNCT
admet-2454	137	9	g.l	g.l	PROPN
admet-2454	137	10	.	.	PROPN
admet-2454	137	11	amidon	amidon	PROPN
admet-2454	137	12	,	,	PUNCT
admet-2454	137	13	g.e	g.e	PROPN
admet-2454	137	14	.	.	PROPN
admet-2454	137	15	amidon	amidon	PROPN
admet-2454	137	16	.	.	PUNCT
admet-2454	138	1	physiological	physiological	ADJ
admet-2454	138	2	parameters	parameter	NOUN
admet-2454	138	3	for	for	ADP
admet-2454	138	4	oral	oral	ADJ
admet-2454	138	5	delivery	delivery	NOUN
admet-2454	138	6	and	and	CCONJ
admet-2454	138	7	in	in	ADP
admet-2454	138	8	vitro	vitro	X
admet-2454	138	9	testing	testing	NOUN
admet-2454	138	10	.	.	PUNCT
admet-2454	139	1	molecular	molecular	ADJ
admet-2454	139	2	pharmaceutics	pharmaceutic	NOUN
admet-2454	139	3	7	7	NUM
admet-2454	139	4	(	(	PUNCT
admet-2454	139	5	2010	2010	NUM
admet-2454	139	6	)	)	PUNCT
admet-2454	139	7	1388	1388	NUM
admet-2454	139	8	-	-	SYM
admet-2454	139	9	1405	1405	NUM
admet-2454	139	10	.	.	PUNCT
admet-2454	140	1	https://doi.org/10.1021/mp100149j	https://doi.org/10.1021/mp100149j	PROPN
admet-2454	140	2	.	.	PUNCT
admet-2454	141	1	[	[	X
admet-2454	141	2	2	2	NUM
admet-2454	141	3	]	]	PUNCT
admet-2454	141	4	k.	k.	PROPN
admet-2454	141	5	sugano	sugano	PROPN
admet-2454	141	6	,	,	PUNCT
admet-2454	141	7	m.	m.	NOUN
admet-2454	141	8	kataoka	kataoka	PROPN
admet-2454	141	9	,	,	PUNCT
admet-2454	141	10	c.	c.	PROPN
admet-2454	141	11	da	da	PROPN
admet-2454	141	12	costa	costa	PROPN
admet-2454	141	13	mathews	mathews	PROPN
admet-2454	141	14	,	,	PUNCT
admet-2454	141	15	s.	s.	PROPN
admet-2454	141	16	yamashita	yamashita	PROPN
admet-2454	141	17	.	.	PUNCT
admet-2454	142	1	prediction	prediction	NOUN
admet-2454	142	2	of	of	ADP
admet-2454	142	3	food	food	NOUN
admet-2454	142	4	effect	effect	NOUN
admet-2454	142	5	by	by	ADP
admet-2454	142	6	bile	bile	NOUN
admet-2454	142	7	micelles	micelle	NOUN
admet-2454	142	8	on	on	ADP
admet-2454	142	9	oral	oral	ADJ
admet-2454	142	10	drug	drug	NOUN
admet-2454	142	11	absorption	absorption	NOUN
admet-2454	142	12	considering	consider	VERB
admet-2454	142	13	free	free	ADJ
admet-2454	142	14	fraction	fraction	NOUN
admet-2454	142	15	in	in	ADP
admet-2454	142	16	intestinal	intestinal	ADJ
admet-2454	142	17	fluid	fluid	NOUN
admet-2454	142	18	.	.	PUNCT
admet-2454	143	1	european	european	ADJ
admet-2454	143	2	journal	journal	PROPN
admet-2454	143	3	of	of	ADP
admet-2454	143	4	pharmaceutical	pharmaceutical	PROPN
admet-2454	143	5	sciences	science	NOUN
admet-2454	143	6	40	40	NUM
admet-2454	143	7	(	(	PUNCT
admet-2454	143	8	2010	2010	NUM
admet-2454	143	9	)	)	PUNCT
admet-2454	143	10	118	118	NUM
admet-2454	143	11	-	-	SYM
admet-2454	143	12	124	124	NUM
admet-2454	143	13	.	.	PUNCT
admet-2454	144	1	https://doi.org/10.1016/j.ejps.2010.03.011	https://doi.org/10.1016/j.ejps.2010.03.011	NOUN
admet-2454	144	2	.	.	PUNCT
admet-2454	145	1	[	[	X
admet-2454	145	2	3	3	NUM
admet-2454	145	3	]	]	PUNCT
admet-2454	145	4	a.	a.	NOUN
admet-2454	145	5	emami	emami	PROPN
admet-2454	145	6	riedmaier	riedmaier	PROPN
admet-2454	145	7	.	.	PUNCT
admet-2454	146	1	predicting	predict	VERB
admet-2454	146	2	food	food	NOUN
admet-2454	146	3	effects	effect	NOUN
admet-2454	146	4	:	:	PUNCT
admet-2454	146	5	are	be	AUX
admet-2454	146	6	we	we	PRON
admet-2454	146	7	there	there	ADV
admet-2454	146	8	yet	yet	ADV
admet-2454	146	9	?	?	PUNCT
admet-2454	147	1	the	the	DET
admet-2454	147	2	aaps	aaps	PROPN
admet-2454	147	3	journal	journal	PROPN
admet-2454	147	4	24	24	NUM
admet-2454	147	5	(	(	PUNCT
admet-2454	147	6	2022	2022	NUM
admet-2454	147	7	)	)	PUNCT
admet-2454	147	8	25	25	NUM
admet-2454	147	9	.	.	PUNCT
admet-2454	148	1	https://doi.org/10.1208/s12248-021-00674-x	https://doi.org/10.1208/s12248-021-00674-x	PROPN
admet-2454	148	2	.	.	PUNCT
admet-2454	149	1	[	[	X
admet-2454	149	2	4	4	X
admet-2454	149	3	]	]	PUNCT
admet-2454	149	4	h.	h.	PROPN
admet-2454	149	5	ramasubramanian	ramasubramanian	PROPN
admet-2454	149	6	,	,	PUNCT
admet-2454	149	7	s.	s.	PROPN
admet-2454	149	8	castleberry	castleberry	PROPN
admet-2454	149	9	.	.	PUNCT
admet-2454	150	1	biopharmaceutical	biopharmaceutical	PROPN
admet-2454	150	2	modeling	modeling	NOUN
admet-2454	150	3	of	of	ADP
admet-2454	150	4	food	food	NOUN
admet-2454	150	5	effect	effect	NOUN
admet-2454	150	6	─	─	VERB
admet-2454	150	7	exploring	explore	VERB
admet-2454	150	8	the	the	DET
admet-2454	150	9	role	role	NOUN
admet-2454	150	10	of	of	ADP
admet-2454	150	11	dietary	dietary	ADJ
admet-2454	150	12	fat	fat	NOUN
admet-2454	150	13	.	.	PUNCT
admet-2454	151	1	molecular	molecular	ADJ
admet-2454	151	2	pharmaceutics	pharmaceutic	NOUN
admet-2454	151	3	20	20	NUM
admet-2454	151	4	(	(	PUNCT
admet-2454	151	5	2023	2023	NUM
admet-2454	151	6	)	)	PUNCT
admet-2454	151	7	2726	2726	NUM
admet-2454	151	8	-	-	SYM
admet-2454	151	9	2737	2737	NUM
admet-2454	151	10	.	.	PUNCT
admet-2454	152	1	https://doi.org/10.1021/acs.molpharmaceut.3c00170	https://doi.org/10.1021/acs.molpharmaceut.3c00170	INTJ
admet-2454	152	2	.	.	PUNCT
admet-2454	153	1	[	[	X
admet-2454	153	2	5	5	X
admet-2454	153	3	]	]	X
admet-2454	153	4	y.	y.	PROPN
admet-2454	153	5	akiyama	akiyama	PROPN
admet-2454	153	6	,	,	PUNCT
admet-2454	153	7	s.	s.	PROPN
admet-2454	153	8	ito	ito	PROPN
admet-2454	153	9	,	,	PUNCT
admet-2454	153	10	t.	t.	PROPN
admet-2454	153	11	fujita	fujita	PROPN
admet-2454	153	12	,	,	PUNCT
admet-2454	153	13	k.	k.	PROPN
admet-2454	153	14	sugano	sugano	PROPN
admet-2454	153	15	.	.	PUNCT
admet-2454	154	1	prediction	prediction	NOUN
admet-2454	154	2	of	of	ADP
admet-2454	154	3	negative	negative	ADJ
admet-2454	154	4	food	food	NOUN
admet-2454	154	5	effect	effect	NOUN
admet-2454	154	6	induced	induce	VERB
admet-2454	154	7	by	by	ADP
admet-2454	154	8	bile	bile	NOUN
admet-2454	154	9	micelle	micelle	NOUN
admet-2454	154	10	binding	bind	VERB
admet-2454	154	11	on	on	ADP
admet-2454	154	12	oral	oral	ADJ
admet-2454	154	13	absorption	absorption	NOUN
admet-2454	154	14	of	of	ADP
admet-2454	154	15	hydrophilic	hydrophilic	ADJ
admet-2454	154	16	cationic	cationic	ADJ
admet-2454	154	17	drugs	drug	NOUN
admet-2454	154	18	.	.	PUNCT
admet-2454	155	1	european	european	ADJ
admet-2454	155	2	journal	journal	PROPN
admet-2454	155	3	of	of	ADP
admet-2454	155	4	pharmaceutical	pharmaceutical	PROPN
admet-2454	155	5	sciences	science	NOUN
admet-2454	155	6	155	155	NUM
admet-2454	155	7	(	(	PUNCT
admet-2454	155	8	2020	2020	NUM
admet-2454	155	9	)	)	PUNCT
admet-2454	155	10	105543	105543	NUM
admet-2454	155	11	.	.	PUNCT
admet-2454	156	1	https://doi.org/10.1016/j.ejps.2020.105543	https://doi.org/10.1016/j.ejps.2020.105543	ADJ
admet-2454	156	2	.	.	PUNCT
admet-2454	157	1	[	[	X
admet-2454	157	2	6	6	NUM
admet-2454	157	3	]	]	PUNCT
admet-2454	157	4	k.	k.	PROPN
admet-2454	157	5	sugano	sugano	PROPN
admet-2454	157	6	,	,	PUNCT
admet-2454	157	7	k.	k.	PROPN
admet-2454	157	8	terada	terada	PROPN
admet-2454	157	9	.	.	PUNCT
admet-2454	158	1	rate	rate	NOUN
admet-2454	158	2	-	-	PUNCT
admet-2454	158	3	and	and	CCONJ
admet-2454	158	4	extent	extent	NOUN
admet-2454	158	5	-	-	PUNCT
admet-2454	158	6	limiting	limit	VERB
admet-2454	158	7	factors	factor	NOUN
admet-2454	158	8	of	of	ADP
admet-2454	158	9	oral	oral	ADJ
admet-2454	158	10	drug	drug	NOUN
admet-2454	158	11	absorption	absorption	NOUN
admet-2454	158	12	:	:	PUNCT
admet-2454	158	13	theory	theory	NOUN
admet-2454	158	14	and	and	CCONJ
admet-2454	158	15	applications	application	NOUN
admet-2454	158	16	.	.	PUNCT
admet-2454	159	1	journal	journal	NOUN
admet-2454	159	2	of	of	ADP
admet-2454	159	3	pharmaceutical	pharmaceutical	PROPN
admet-2454	159	4	sciences	science	NOUN
admet-2454	159	5	104	104	NUM
admet-2454	159	6	(	(	PUNCT
admet-2454	159	7	2015	2015	NUM
admet-2454	159	8	)	)	PUNCT
admet-2454	159	9	2777	2777	NUM
admet-2454	159	10	-	-	SYM
admet-2454	159	11	2788	2788	NUM
admet-2454	159	12	.	.	PUNCT
admet-2454	160	1	https://doi.org/10.1002/jps.24391	https://doi.org/10.1002/jps.24391	NOUN
admet-2454	160	2	.	.	PUNCT
admet-2454	161	1	[	[	X
admet-2454	161	2	7	7	X
admet-2454	161	3	]	]	X
admet-2454	161	4	t.	t.	NOUN
admet-2454	161	5	sumiji	sumiji	PROPN
admet-2454	161	6	,	,	PUNCT
admet-2454	161	7	k.	k.	PROPN
admet-2454	161	8	sugano	sugano	PROPN
admet-2454	161	9	.	.	PUNCT
admet-2454	162	1	food	food	NOUN
admet-2454	162	2	and	and	CCONJ
admet-2454	162	3	bile	bile	NOUN
admet-2454	162	4	micelle	micelle	NOUN
admet-2454	162	5	binding	bind	VERB
admet-2454	162	6	of	of	ADP
admet-2454	162	7	quaternary	quaternary	ADJ
admet-2454	162	8	ammonium	ammonium	NOUN
admet-2454	162	9	compounds	compound	NOUN
admet-2454	162	10	.	.	PUNCT
admet-2454	163	1	admet	admet	PROPN
admet-2454	163	2	and	and	CCONJ
admet-2454	163	3	dmpk	dmpk	X
admet-2454	163	4	11	11	NUM
admet-2454	163	5	(	(	PUNCT
admet-2454	163	6	2023	2023	NUM
admet-2454	163	7	)	)	PUNCT
admet-2454	163	8	409	409	NUM
admet-2454	163	9	-	-	SYM
admet-2454	163	10	417	417	NUM
admet-2454	163	11	.	.	PUNCT
admet-2454	163	12	https://doi.org/10.5599/admet.2023	https://doi.org/10.5599/admet.2023	X
admet-2454	163	13	.	.	PUNCT
admet-2454	164	1	[	[	X
admet-2454	164	2	8	8	NUM
admet-2454	164	3	]	]	X
admet-2454	164	4	taiho	taiho	PROPN
admet-2454	164	5	pharmaceutical	pharmaceutical	PROPN
admet-2454	164	6	co.	co.	PROPN
admet-2454	164	7	,	,	PUNCT
admet-2454	164	8	ltd	ltd	PROPN
admet-2454	164	9	.	.	PROPN
admet-2454	164	10	bilastine	bilastine	PROPN
admet-2454	164	11	drug	drug	NOUN
admet-2454	164	12	product	product	NOUN
admet-2454	164	13	information	information	NOUN
admet-2454	164	14	.	.	PUNCT
admet-2454	165	1	https://www.taiho.co.jp/medical/product/detail/index.html?_productgroupid=990	https://www.taiho.co.jp/medical/product/detail/index.html?_productgroupid=990	NOUN
admet-2454	165	2	.	.	PUNCT
admet-2454	166	1	[	[	X
admet-2454	166	2	9	9	NUM
admet-2454	166	3	]	]	PUNCT
admet-2454	166	4	p.	p.	NOUN
admet-2454	166	5	paśko	paśko	PROPN
admet-2454	166	6	,	,	PUNCT
admet-2454	166	7	t.	t.	PROPN
admet-2454	166	8	rodacki	rodacki	PROPN
admet-2454	166	9	,	,	PUNCT
admet-2454	166	10	r.	r.	PROPN
admet-2454	166	11	domagała	domagała	PROPN
admet-2454	166	12	-	-	PUNCT
admet-2454	166	13	rodacka	rodacka	PROPN
admet-2454	166	14	,	,	PUNCT
admet-2454	166	15	k.	k.	PROPN
admet-2454	166	16	palimonka	palimonka	PROPN
admet-2454	166	17	,	,	PUNCT
admet-2454	166	18	m.	m.	NOUN
admet-2454	166	19	marcinkowska	marcinkowska	PROPN
admet-2454	166	20	,	,	PUNCT
admet-2454	166	21	d.	d.	PROPN
admet-2454	166	22	owczarek	owczarek	PROPN
admet-2454	166	23	.	.	PUNCT
admet-2454	167	1	second	second	ADJ
admet-2454	167	2	generation	generation	NOUN
admet-2454	167	3	h1	h1	NOUN
admet-2454	167	4	-	-	PUNCT
admet-2454	167	5	antihistamines	antihistamine	NOUN
admet-2454	167	6	interaction	interaction	NOUN
admet-2454	167	7	with	with	ADP
admet-2454	167	8	food	food	NOUN
admet-2454	167	9	and	and	CCONJ
admet-2454	167	10	alcohol	alcohol	NOUN
admet-2454	167	11	—	—	PUNCT
admet-2454	167	12	a	a	DET
admet-2454	167	13	systematic	systematic	ADJ
admet-2454	167	14	review	review	NOUN
admet-2454	167	15	.	.	PUNCT
admet-2454	168	1	biomedicine	biomedicine	NOUN
admet-2454	168	2	&	&	CCONJ
admet-2454	168	3	pharmacotherapy	pharmacotherapy	NOUN
admet-2454	168	4	93	93	NUM
admet-2454	168	5	(	(	PUNCT
admet-2454	168	6	2017	2017	NUM
admet-2454	168	7	)	)	PUNCT
admet-2454	168	8	27	27	NUM
admet-2454	168	9	-	-	SYM
admet-2454	168	10	39	39	NUM
admet-2454	168	11	.	.	PUNCT
admet-2454	169	1	https://doi.org/10.1016/j.biopha.2017.06.008	https://doi.org/10.1016/j.biopha.2017.06.008	NOUN
admet-2454	169	2	.	.	PUNCT
admet-2454	170	1	[	[	X
admet-2454	170	2	10	10	NUM
admet-2454	170	3	]	]	X
admet-2454	170	4	j.	j.	PROPN
admet-2454	170	5	coimbra	coimbra	PROPN
admet-2454	170	6	,	,	PUNCT
admet-2454	170	7	m.	m.	NOUN
admet-2454	170	8	puntes	punte	NOUN
admet-2454	170	9	,	,	PUNCT
admet-2454	170	10	i.	i.	PROPN
admet-2454	170	11	gich	gich	PROPN
admet-2454	170	12	,	,	PUNCT
admet-2454	170	13	j.	j.	PROPN
admet-2454	170	14	martínez	martínez	PROPN
admet-2454	170	15	,	,	PUNCT
admet-2454	170	16	p.	p.	PROPN
admet-2454	170	17	molina	molina	PROPN
admet-2454	170	18	,	,	PUNCT
admet-2454	170	19	r.	r.	PROPN
admet-2454	170	20	antonijoan	antonijoan	PROPN
admet-2454	170	21	,	,	PUNCT
admet-2454	170	22	c.	c.	PROPN
admet-2454	170	23	campo	campo	PROPN
admet-2454	170	24	,	,	PUNCT
admet-2454	170	25	l.	l.	PROPN
admet-2454	170	26	labeaga	labeaga	PROPN
admet-2454	170	27	.	.	PUNCT
admet-2454	171	1	lack	lack	NOUN
admet-2454	171	2	of	of	ADP
admet-2454	171	3	clinical	clinical	ADJ
admet-2454	171	4	relevance	relevance	NOUN
admet-2454	171	5	of	of	ADP
admet-2454	171	6	bilastine	bilastine	ADJ
admet-2454	171	7	-	-	PUNCT
admet-2454	171	8	food	food	NOUN
admet-2454	171	9	interaction	interaction	NOUN
admet-2454	171	10	in	in	ADP
admet-2454	171	11	healthy	healthy	ADJ
admet-2454	171	12	volunteers	volunteer	NOUN
admet-2454	171	13	:	:	PUNCT
admet-2454	171	14	a	a	DET
admet-2454	171	15	wheal	wheal	ADJ
admet-2454	171	16	and	and	CCONJ
admet-2454	171	17	flare	flare	PROPN
admet-2454	171	18	study	study	NOUN
admet-2454	171	19	.	.	PUNCT
admet-2454	172	1	international	international	ADJ
admet-2454	172	2	archives	archive	NOUN
admet-2454	172	3	of	of	ADP
admet-2454	172	4	allergy	allergy	NOUN
admet-2454	172	5	and	and	CCONJ
admet-2454	172	6	immunology	immunology	NOUN
admet-2454	172	7	183	183	NUM
admet-2454	172	8	(	(	PUNCT
admet-2454	172	9	2022	2022	NUM
admet-2454	172	10	)	)	PUNCT
admet-2454	172	11	1241	1241	NUM
admet-2454	172	12	-	-	SYM
admet-2454	172	13	1250	1250	NUM
admet-2454	172	14	.	.	PUNCT
admet-2454	173	1	https://doi.org/10.1159/000524856	https://doi.org/10.1159/000524856	NOUN
admet-2454	173	2	.	.	PUNCT
admet-2454	174	1	[	[	X
admet-2454	174	2	11	11	NUM
admet-2454	174	3	]	]	X
admet-2454	174	4	gsk	gsk	NOUN
admet-2454	174	5	.	.	PUNCT
admet-2454	174	6	cetrizine	cetrizine	PROPN
admet-2454	174	7	drug	drug	NOUN
admet-2454	174	8	product	product	NOUN
admet-2454	174	9	information	information	NOUN
admet-2454	174	10	.	.	PUNCT
admet-2454	175	1	https://gskpro.com/ja-jp/products-info/zyrtec/index/.	https://gskpro.com/ja-jp/products-info/zyrtec/index/.	X
admet-2454	176	1	[	[	X
admet-2454	176	2	12	12	NUM
admet-2454	176	3	]	]	X
admet-2454	176	4	[	[	X
admet-2454	176	5	sanofi	sanofi	PROPN
admet-2454	176	6	.	.	PUNCT
admet-2454	176	7	fexofenadine	fexofenadine	PROPN
admet-2454	176	8	drug	drug	NOUN
admet-2454	176	9	product	product	NOUN
admet-2454	176	10	information	information	NOUN
admet-2454	176	11	.	.	PUNCT
admet-2454	177	1	https://www.e-mr.sanofi.co.jp/dam/jcr:2d468ede5f77-43ce-9d19-057401361c43/allegra.pdf	https://www.e-mr.sanofi.co.jp/dam/jcr:2d468ede5f77-43ce-9d19-057401361c43/allegra.pdf	PROPN
admet-2454	177	2	.	.	PUNCT
admet-2454	178	1	[	[	X
admet-2454	178	2	13	13	NUM
admet-2454	178	3	]	]	PUNCT
admet-2454	178	4	m.	m.	NOUN
admet-2454	178	5	stoltz	stoltz	PROPN
admet-2454	178	6	,	,	PUNCT
admet-2454	178	7	t.	t.	PROPN
admet-2454	178	8	arumugham	arumugham	PROPN
admet-2454	178	9	,	,	PUNCT
admet-2454	178	10	c.	c.	PROPN
admet-2454	178	11	lippert	lippert	PROPN
admet-2454	178	12	,	,	PUNCT
admet-2454	178	13	d.	d.	PROPN
admet-2454	178	14	yu	yu	PROPN
admet-2454	178	15	,	,	PUNCT
admet-2454	178	16	v.	v.	PROPN
admet-2454	178	17	bhargava	bhargava	PROPN
admet-2454	178	18	,	,	PUNCT
admet-2454	178	19	m.	m.	NOUN
admet-2454	178	20	eller	eller	PROPN
admet-2454	178	21	,	,	PUNCT
admet-2454	178	22	s.	s.	PROPN
admet-2454	178	23	weir	weir	PROPN
admet-2454	178	24	.	.	PROPN
admet-2454	179	1	effect	effect	NOUN
admet-2454	179	2	of	of	ADP
admet-2454	179	3	food	food	NOUN
admet-2454	179	4	on	on	ADP
admet-2454	179	5	the	the	DET
admet-2454	179	6	bioavailability	bioavailability	NOUN
admet-2454	179	7	of	of	ADP
admet-2454	179	8	fexofenadine	fexofenadine	ADJ
admet-2454	179	9	hydrochloride	hydrochloride	NOUN
admet-2454	179	10	(	(	PUNCT
admet-2454	179	11	mdl	mdl	PROPN
admet-2454	179	12	16455a	16455a	NUM
admet-2454	179	13	)	)	PUNCT
admet-2454	179	14	.	.	PUNCT
admet-2454	180	1	biopharmaceutics	biopharmaceutics	NOUN
admet-2454	180	2	and	and	CCONJ
admet-2454	180	3	drug	drug	NOUN
admet-2454	180	4	disposition	disposition	NOUN
admet-2454	180	5	18	18	NUM
admet-2454	180	6	(	(	PUNCT
admet-2454	180	7	1997	1997	NUM
admet-2454	180	8	)	)	PUNCT
admet-2454	180	9	645	645	NUM
admet-2454	180	10	-	-	SYM
admet-2454	180	11	648	648	NUM
admet-2454	180	12	.	.	PUNCT
admet-2454	181	1	https://doi.org/10.1002/(sici)1099-081x(199710)18:7<645::aidbdd50>3.0.co;2-3	https://doi.org/10.1002/(sici)1099-081x(199710)18:7<645::aidbdd50>3.0.co;2-3	NOUN
admet-2454	181	2	.	.	PUNCT
admet-2454	182	1	[	[	X
admet-2454	182	2	14	14	NUM
admet-2454	182	3	]	]	X
admet-2454	182	4	kyowa	kyowa	PROPN
admet-2454	182	5	kirin	kirin	PROPN
admet-2454	182	6	co.	co.	PROPN
admet-2454	182	7	,	,	PUNCT
admet-2454	182	8	ltd	ltd	PROPN
admet-2454	182	9	.	.	PROPN
admet-2454	182	10	olopatadine	olopatadine	PROPN
admet-2454	182	11	drug	drug	NOUN
admet-2454	182	12	product	product	NOUN
admet-2454	182	13	information	information	NOUN
admet-2454	182	14	.	.	PUNCT
admet-2454	183	1	https://medical.kyowakirin.co.jp/site/drugpdf/interv/alk_in.pdf	https://medical.kyowakirin.co.jp/site/drugpdf/interv/alk_in.pdf	NOUN
admet-2454	183	2	.	.	PUNCT
admet-2454	184	1	[	[	X
admet-2454	184	2	15	15	NUM
admet-2454	184	3	]	]	X
admet-2454	184	4	a.	a.	NOUN
admet-2454	184	5	avdeef	avdeef	PROPN
admet-2454	184	6	.	.	PUNCT
admet-2454	185	1	absorption	absorption	NOUN
admet-2454	185	2	and	and	CCONJ
admet-2454	185	3	drug	drug	NOUN
admet-2454	185	4	development	development	NOUN
admet-2454	185	5	:	:	PUNCT
admet-2454	185	6	solubility	solubility	NOUN
admet-2454	185	7	,	,	PUNCT
admet-2454	185	8	permeability	permeability	NOUN
admet-2454	185	9	,	,	PUNCT
admet-2454	185	10	and	and	CCONJ
admet-2454	185	11	charge	charge	NOUN
admet-2454	185	12	state	state	NOUN
admet-2454	185	13	,	,	PUNCT
admet-2454	185	14	second	second	ADJ
admet-2454	185	15	edition	edition	NOUN
admet-2454	185	16	,	,	PUNCT
admet-2454	185	17	john	john	PROPN
admet-2454	185	18	wiley	wiley	PROPN
admet-2454	185	19	&	&	CCONJ
admet-2454	185	20	sons	sons	PROPN
admet-2454	185	21	,	,	PUNCT
admet-2454	185	22	inc	inc	PROPN
admet-2454	185	23	.	.	PROPN
admet-2454	185	24	,	,	PUNCT
admet-2454	185	25	2012	2012	NUM
admet-2454	185	26	.	.	PUNCT
admet-2454	186	1	print	print	NOUN
admet-2454	186	2	isbn:9781118057452	isbn:9781118057452	NOUN
admet-2454	186	3	[	[	X
admet-2454	186	4	16	16	NUM
admet-2454	186	5	]	]	X
admet-2454	186	6	g.k	g.k	PROPN
admet-2454	186	7	.	.	PROPN
admet-2454	186	8	dresser	dresser	PROPN
admet-2454	186	9	,	,	PUNCT
admet-2454	186	10	d.g	d.g	PROPN
admet-2454	186	11	.	.	PROPN
admet-2454	186	12	bailey	bailey	PROPN
admet-2454	186	13	,	,	PUNCT
admet-2454	186	14	b.f	b.f	PROPN
admet-2454	186	15	.	.	PROPN
admet-2454	186	16	leake	leake	PROPN
admet-2454	186	17	,	,	PUNCT
admet-2454	186	18	u.i	u.i	PROPN
admet-2454	186	19	.	.	PROPN
admet-2454	186	20	schwarz	schwarz	PROPN
admet-2454	186	21	,	,	PUNCT
admet-2454	186	22	p.a	p.a	PROPN
admet-2454	186	23	.	.	PROPN
admet-2454	186	24	dawson	dawson	PROPN
admet-2454	186	25	,	,	PUNCT
admet-2454	186	26	d.j	d.j	PROPN
admet-2454	186	27	.	.	PROPN
admet-2454	186	28	freeman	freeman	PROPN
admet-2454	186	29	,	,	PUNCT
admet-2454	186	30	r.b	r.b	PROPN
admet-2454	186	31	.	.	PROPN
admet-2454	186	32	kim	kim	PROPN
admet-2454	186	33	.	.	PUNCT
admet-2454	187	1	fruit	fruit	NOUN
admet-2454	187	2	juices	juice	NOUN
admet-2454	187	3	inhibit	inhibit	VERB
admet-2454	187	4	organic	organic	ADJ
admet-2454	187	5	anion	anion	NOUN
admet-2454	187	6	transporting	transport	VERB
admet-2454	187	7	polypeptide	polypeptide	ADJ
admet-2454	187	8	-	-	PUNCT
admet-2454	187	9	mediated	mediate	VERB
admet-2454	187	10	drug	drug	NOUN
admet-2454	187	11	uptake	uptake	ADJ
admet-2454	187	12	to	to	PART
admet-2454	187	13	decrease	decrease	VERB
admet-2454	187	14	the	the	DET
admet-2454	187	15	oral	oral	ADJ
admet-2454	187	16	availability	availability	NOUN
admet-2454	187	17	of	of	ADP
admet-2454	187	18	fexofenadine	fexofenadine	NOUN
admet-2454	187	19	.	.	PUNCT
admet-2454	188	1	clinical	clinical	ADJ
admet-2454	188	2	pharmacology	pharmacology	NOUN
admet-2454	188	3	and	and	CCONJ
admet-2454	188	4	therapeutics	therapeutic	NOUN
admet-2454	188	5	71	71	NUM
admet-2454	188	6	(	(	PUNCT
admet-2454	188	7	2002	2002	NUM
admet-2454	188	8	)	)	PUNCT
admet-2454	188	9	11	11	NUM
admet-2454	188	10	-	-	SYM
admet-2454	188	11	20	20	NUM
admet-2454	188	12	.	.	PUNCT
admet-2454	189	1	https://doi.org/10.1067/mcp.2002.121152	https://doi.org/10.1067/mcp.2002.121152	PROPN
admet-2454	189	2	.	.	PUNCT
admet-2454	190	1	[	[	X
admet-2454	190	2	17	17	NUM
admet-2454	190	3	]	]	PUNCT
admet-2454	190	4	a.	a.	NOUN
admet-2454	190	5	marosi	marosi	PROPN
admet-2454	190	6	,	,	PUNCT
admet-2454	190	7	z.	z.	PROPN
admet-2454	190	8	kovács	kovács	PROPN
admet-2454	190	9	,	,	PUNCT
admet-2454	190	10	s.	s.	PROPN
admet-2454	190	11	béni	béni	PROPN
admet-2454	190	12	,	,	PUNCT
admet-2454	190	13	j.	j.	PROPN
admet-2454	190	14	kökösi	kökösi	PROPN
admet-2454	190	15	,	,	PUNCT
admet-2454	190	16	b.	b.	PROPN
admet-2454	190	17	noszál	noszál	PROPN
admet-2454	190	18	.	.	PUNCT
admet-2454	191	1	triprotic	triprotic	ADJ
admet-2454	191	2	acid	acid	NOUN
admet-2454	191	3	-	-	PUNCT
admet-2454	191	4	base	base	NOUN
admet-2454	191	5	microequilibria	microequilibria	NOUN
admet-2454	191	6	and	and	CCONJ
admet-2454	191	7	pharmacokinetic	pharmacokinetic	ADJ
admet-2454	191	8	sequelae	sequelae	NOUN
admet-2454	191	9	of	of	ADP
admet-2454	191	10	cetirizine	cetirizine	NOUN
admet-2454	191	11	.	.	PUNCT
admet-2454	192	1	european	european	ADJ
admet-2454	192	2	journal	journal	PROPN
admet-2454	192	3	of	of	ADP
admet-2454	192	4	pharmaceutical	pharmaceutical	PROPN
admet-2454	192	5	sciences	science	NOUN
admet-2454	192	6	37	37	NUM
admet-2454	192	7	(	(	PUNCT
admet-2454	192	8	2009	2009	NUM
admet-2454	192	9	)	)	PUNCT
admet-2454	192	10	321328	321328	NUM
admet-2454	192	11	.	.	PUNCT
admet-2454	193	1	https://doi.org/10.1016/j.ejps.2009.03.001	https://doi.org/10.1016/j.ejps.2009.03.001	PROPN
admet-2454	193	2	.	.	PUNCT
admet-2454	194	1	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	PROPN
admet-2454	194	2	https://doi.org/10.1021/mp100149j	https://doi.org/10.1021/mp100149j	VERB
admet-2454	195	1	https://doi.org/10.1016/j.ejps.2010.03.011	https://doi.org/10.1016/j.ejps.2010.03.011	PROPN
admet-2454	195	2	https://doi.org/10.1208/s12248-021-00674-x	https://doi.org/10.1208/s12248-021-00674-x	PROPN
admet-2454	195	3	https://doi.org/10.1021/acs.molpharmaceut.3c00170	https://doi.org/10.1021/acs.molpharmaceut.3c00170	ADV
admet-2454	195	4	https://doi.org/10.1016/j.ejps.2020.105543	https://doi.org/10.1016/j.ejps.2020.105543	ADJ
admet-2454	195	5	https://doi.org/10.1002/jps.24391	https://doi.org/10.1002/jps.24391	PROPN
admet-2454	195	6	https://doi.org/10.5599/admet.2023	https://doi.org/10.5599/admet.2023	ADJ
admet-2454	195	7	https://doi.org/10.1016/j.biopha.2017.06.008	https://doi.org/10.1016/j.biopha.2017.06.008	PROPN
admet-2454	195	8	https://doi.org/10.1159/000524856	https://doi.org/10.1159/000524856	NOUN
admet-2454	195	9	https://gskpro.com/ja-jp/products-info/zyrtec/index/	https://gskpro.com/ja-jp/products-info/zyrtec/index/	PROPN
admet-2454	195	10	https://www.e-mr.sanofi.co.jp/dam/jcr:2d468ede-5f77-43ce-9d19-057401361c43/allegra.pdf	https://www.e-mr.sanofi.co.jp/dam/jcr:2d468ede-5f77-43ce-9d19-057401361c43/allegra.pdf	PROPN
admet-2454	195	11	https://www.e-mr.sanofi.co.jp/dam/jcr:2d468ede-5f77-43ce-9d19-057401361c43/allegra.pdf	https://www.e-mr.sanofi.co.jp/dam/jcr:2d468ede-5f77-43ce-9d19-057401361c43/allegra.pdf	PROPN
admet-2454	195	12	https://doi.org/10.1002/(sici)1099-081x(199710)18:7%3c645::aid-bdd50%3e3.0.co;2-3	https://doi.org/10.1002/(sici)1099-081x(199710)18:7%3c645::aid-bdd50%3e3.0.co;2-3	PROPN
admet-2454	195	13	https://doi.org/10.1002/(sici)1099-081x(199710)18:7%3c645::aid-bdd50%3e3.0.co;2-3	https://doi.org/10.1002/(sici)1099-081x(199710)18:7%3c645::aid-bdd50%3e3.0.co;2-3	PROPN
admet-2454	195	14	https://medical.kyowakirin.co.jp/site/drugpdf/interv/alk_in.pdf	https://medical.kyowakirin.co.jp/site/drugpdf/interv/alk_in.pdf	PROPN
admet-2454	195	15	https://doi.org/10.1067/mcp.2002.121152	https://doi.org/10.1067/mcp.2002.121152	PROPN
admet-2454	195	16	https://doi.org/10.1016/j.ejps.2009.03.001	https://doi.org/10.1016/j.ejps.2009.03.001	PROPN
admet-2454	195	17	r.	r.	PROPN
admet-2454	195	18	takeuchi	takeuchi	PROPN
admet-2454	195	19	and	and	CCONJ
admet-2454	195	20	k.	k.	PROPN
admet-2454	195	21	sugano	sugano	PROPN
admet-2454	195	22	admet	admet	PROPN
admet-2454	195	23	&	&	CCONJ
admet-2454	195	24	dmpk	dmpk	PROPN
admet-2454	195	25	12(4	12(4	PROPN
admet-2454	195	26	)	)	PUNCT
admet-2454	195	27	(	(	PUNCT
admet-2454	195	28	2024	2024	NUM
admet-2454	195	29	)	)	PUNCT
admet-2454	195	30	649	649	NUM
admet-2454	195	31	-	-	SYM
admet-2454	195	32	656	656	NUM
admet-2454	195	33	656	656	NUM
admet-2454	195	34	[	[	SYM
admet-2454	195	35	18	18	NUM
admet-2454	195	36	]	]	X
admet-2454	195	37	g.p	g.p	PROPN
admet-2454	195	38	.	.	PROPN
admet-2454	195	39	van	van	PROPN
admet-2454	195	40	balen	balen	PROPN
admet-2454	195	41	,	,	PUNCT
admet-2454	195	42	g.	g.	PROPN
admet-2454	195	43	caron	caron	PROPN
admet-2454	195	44	,	,	PUNCT
admet-2454	195	45	g.	g.	PROPN
admet-2454	195	46	ermondi	ermondi	PROPN
admet-2454	195	47	,	,	PUNCT
admet-2454	195	48	a.	a.	NOUN
admet-2454	195	49	pagliara	pagliara	PROPN
admet-2454	195	50	,	,	PUNCT
admet-2454	195	51	t.	t.	PROPN
admet-2454	195	52	grandi	grandi	PROPN
admet-2454	195	53	,	,	PUNCT
admet-2454	195	54	g.	g.	PROPN
admet-2454	195	55	bouchard	bouchard	PROPN
admet-2454	195	56	,	,	PUNCT
admet-2454	195	57	r.	r.	PROPN
admet-2454	195	58	fruttero	fruttero	PROPN
admet-2454	195	59	,	,	PUNCT
admet-2454	195	60	p.-a	p.-a	NOUN
admet-2454	195	61	.	.	PUNCT
admet-2454	196	1	carrupt	carrupt	PROPN
admet-2454	196	2	,	,	PUNCT
admet-2454	196	3	b.	b.	PROPN
admet-2454	196	4	testa	testa	PROPN
admet-2454	196	5	.	.	PUNCT
admet-2454	197	1	lipophilicity	lipophilicity	NOUN
admet-2454	197	2	behaviour	behaviour	NOUN
admet-2454	197	3	of	of	ADP
admet-2454	197	4	the	the	DET
admet-2454	197	5	zwitterionic	zwitterionic	ADJ
admet-2454	197	6	antihistamine	antihistamine	PROPN
admet-2454	197	7	cetirizine	cetirizine	NOUN
admet-2454	197	8	in	in	ADP
admet-2454	197	9	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2454	197	10	liposomes	liposome	NOUN
admet-2454	197	11	/	/	SYM
admet-2454	197	12	water	water	NOUN
admet-2454	197	13	systems	system	NOUN
admet-2454	197	14	.	.	PUNCT
admet-2454	198	1	pharmaceutical	pharmaceutical	PROPN
admet-2454	198	2	research	research	NOUN
admet-2454	198	3	18	18	NUM
admet-2454	198	4	(	(	PUNCT
admet-2454	198	5	2001	2001	NUM
admet-2454	198	6	)	)	PUNCT
admet-2454	198	7	694	694	NUM
admet-2454	198	8	-	-	SYM
admet-2454	198	9	701	701	NUM
admet-2454	198	10	.	.	PUNCT
admet-2454	198	11	https://doi.org/10.1023/a:1011049830615	https://doi.org/10.1023/a:1011049830615	PROPN
admet-2454	198	12	.	.	PUNCT
admet-2454	199	1	[	[	X
admet-2454	199	2	19	19	NUM
admet-2454	199	3	]	]	PUNCT
admet-2454	199	4	k.	k.	PROPN
admet-2454	199	5	bittermann	bittermann	PROPN
admet-2454	199	6	,	,	PUNCT
admet-2454	199	7	s.	s.	PROPN
admet-2454	199	8	spycher	spycher	PROPN
admet-2454	199	9	,	,	PUNCT
admet-2454	199	10	k.-u	k.-u	PROPN
admet-2454	199	11	.	.	PUNCT
admet-2454	200	1	goss	goss	PROPN
admet-2454	200	2	.	.	PUNCT
admet-2454	201	1	comparison	comparison	NOUN
admet-2454	201	2	of	of	ADP
admet-2454	201	3	different	different	ADJ
admet-2454	201	4	models	model	NOUN
admet-2454	201	5	predicting	predict	VERB
admet-2454	201	6	the	the	DET
admet-2454	201	7	phospholipidmembrane	phospholipidmembrane	NOUN
admet-2454	201	8	water	water	NOUN
admet-2454	201	9	partition	partition	NOUN
admet-2454	201	10	coefficients	coefficient	NOUN
admet-2454	201	11	of	of	ADP
admet-2454	201	12	charged	charge	VERB
admet-2454	201	13	compounds	compound	NOUN
admet-2454	201	14	.	.	PUNCT
admet-2454	202	1	chemosphere	chemosphere	PROPN
admet-2454	202	2	144	144	NUM
admet-2454	202	3	(	(	PUNCT
admet-2454	202	4	2016	2016	NUM
admet-2454	202	5	)	)	PUNCT
admet-2454	202	6	382	382	NUM
admet-2454	202	7	-	-	SYM
admet-2454	202	8	391	391	NUM
admet-2454	202	9	.	.	PUNCT
admet-2454	203	1	https://doi.org/10.1016/j.chemosphere.2015.08.065	https://doi.org/10.1016/j.chemosphere.2015.08.065	NOUN
admet-2454	203	2	.	.	PUNCT
admet-2454	204	1	[	[	X
admet-2454	204	2	20	20	NUM
admet-2454	204	3	]	]	PUNCT
admet-2454	204	4	a.	a.	NOUN
admet-2454	204	5	pagliara	pagliara	PROPN
admet-2454	204	6	,	,	PUNCT
admet-2454	204	7	p.a	p.a	PROPN
admet-2454	204	8	.	.	PROPN
admet-2454	204	9	carrupt	carrupt	PROPN
admet-2454	204	10	,	,	PUNCT
admet-2454	204	11	g.	g.	PROPN
admet-2454	204	12	caron	caron	PROPN
admet-2454	204	13	,	,	PUNCT
admet-2454	204	14	p.	p.	PROPN
admet-2454	204	15	gaillard	gaillard	PROPN
admet-2454	204	16	,	,	PUNCT
admet-2454	204	17	b.	b.	PROPN
admet-2454	204	18	testa	testa	PROPN
admet-2454	204	19	.	.	PUNCT
admet-2454	205	1	lipophilicity	lipophilicity	NOUN
admet-2454	205	2	profiles	profile	NOUN
admet-2454	205	3	of	of	ADP
admet-2454	205	4	ampholytes	ampholyte	NOUN
admet-2454	205	5	.	.	PUNCT
admet-2454	206	1	chemical	chemical	ADJ
admet-2454	206	2	reviews	review	NOUN
admet-2454	206	3	97	97	NUM
admet-2454	206	4	(	(	PUNCT
admet-2454	206	5	1997	1997	NUM
admet-2454	206	6	)	)	PUNCT
admet-2454	206	7	3385	3385	NUM
admet-2454	206	8	-	-	SYM
admet-2454	206	9	3400	3400	NUM
admet-2454	206	10	.	.	PUNCT
admet-2454	207	1	https://doi.org/10.1021/cr9601019	https://doi.org/10.1021/cr9601019	X
admet-2454	207	2	.	.	PUNCT
admet-2454	208	1	[	[	X
admet-2454	208	2	21	21	NUM
admet-2454	208	3	]	]	X
admet-2454	208	4	a.	a.	NOUN
admet-2454	208	5	ebert	ebert	PROPN
admet-2454	208	6	,	,	PUNCT
admet-2454	208	7	c.	c.	PROPN
admet-2454	208	8	dahley	dahley	PROPN
admet-2454	208	9	.	.	PUNCT
admet-2454	209	1	can	can	AUX
admet-2454	209	2	membrane	membrane	VERB
admet-2454	209	3	permeability	permeability	NOUN
admet-2454	209	4	of	of	ADP
admet-2454	209	5	zwitterionic	zwitterionic	ADJ
admet-2454	209	6	compounds	compound	NOUN
admet-2454	209	7	be	be	AUX
admet-2454	209	8	predicted	predict	VERB
admet-2454	209	9	by	by	ADP
admet-2454	209	10	the	the	DET
admet-2454	209	11	solubility	solubility	NOUN
admet-2454	209	12	diffusion	diffusion	NOUN
admet-2454	209	13	model	model	NOUN
admet-2454	209	14	?	?	PUNCT
admet-2454	210	1	european	european	ADJ
admet-2454	210	2	journal	journal	PROPN
admet-2454	210	3	of	of	ADP
admet-2454	210	4	pharmaceutical	pharmaceutical	PROPN
admet-2454	210	5	sciences	science	NOUN
admet-2454	210	6	(	(	PUNCT
admet-2454	210	7	2024	2024	NUM
admet-2454	210	8	)	)	PUNCT
admet-2454	210	9	106819	106819	NUM
admet-2454	210	10	.	.	PUNCT
admet-2454	211	1	https://doi.org/10.1016/j.ejps.2024.106819	https://doi.org/10.1016/j.ejps.2024.106819	NOUN
admet-2454	211	2	.	.	PUNCT
admet-2454	212	1	©	©	ADP
admet-2454	212	2	2024	2024	NUM
admet-2454	212	3	by	by	ADP
admet-2454	212	4	the	the	DET
admet-2454	212	5	authors	author	NOUN
admet-2454	212	6	;	;	PUNCT
admet-2454	212	7	licensee	licensee	PROPN
admet-2454	212	8	iapc	iapc	PROPN
admet-2454	212	9	,	,	PUNCT
admet-2454	212	10	zagreb	zagreb	PROPN
admet-2454	212	11	,	,	PUNCT
admet-2454	212	12	croatia	croatia	PROPN
admet-2454	212	13	.	.	PUNCT
admet-2454	213	1	this	this	DET
admet-2454	213	2	article	article	NOUN
admet-2454	213	3	is	be	AUX
admet-2454	213	4	an	an	DET
admet-2454	213	5	open	open	ADJ
admet-2454	213	6	-	-	PUNCT
admet-2454	213	7	access	access	NOUN
admet-2454	213	8	article	article	NOUN
admet-2454	213	9	distributed	distribute	VERB
admet-2454	213	10	under	under	ADP
admet-2454	213	11	the	the	DET
admet-2454	213	12	terms	term	NOUN
admet-2454	213	13	and	and	CCONJ
admet-2454	213	14	conditions	condition	NOUN
admet-2454	213	15	of	of	ADP
admet-2454	213	16	the	the	DET
admet-2454	213	17	creative	creative	ADJ
admet-2454	213	18	commons	common	NOUN
admet-2454	213	19	attribution	attribution	NOUN
admet-2454	213	20	license	license	NOUN
admet-2454	213	21	(	(	PUNCT
admet-2454	213	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2454	213	23	)	)	PUNCT
admet-2454	213	24	https://doi.org/10.1023/a:1011049830615	https://doi.org/10.1023/a:1011049830615	PROPN
admet-2454	213	25	https://doi.org/10.1016/j.chemosphere.2015.08.065	https://doi.org/10.1016/j.chemosphere.2015.08.065	PROPN
admet-2454	213	26	https://doi.org/10.1021/cr9601019	https://doi.org/10.1021/cr9601019	PRON
admet-2454	213	27	https://doi.org/10.1016/j.ejps.2024.106819	https://doi.org/10.1016/j.ejps.2024.106819	VERB
admet-2454	213	28	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN