id	sid	tid	token	lemma	pos
admet-2455	1	1	targeting	target	VERB
admet-2455	1	2	hexokinase	hexokinase	NOUN
admet-2455	1	3	2	2	NUM
admet-2455	1	4	to	to	PART
admet-2455	1	5	enhance	enhance	VERB
admet-2455	1	6	anticancer	anticancer	NOUN
admet-2455	1	7	efficacy	efficacy	NOUN
admet-2455	1	8	of	of	ADP
admet-2455	1	9	trichosanthin	trichosanthin	PROPN
admet-2455	1	10	in	in	ADP
admet-2455	1	11	hela	hela	PROPN
admet-2455	1	12	and	and	CCONJ
admet-2455	1	13	scc25	scc25	PROPN
admet-2455	1	14	cell	cell	NOUN
admet-2455	1	15	models	model	NOUN
admet-2455	1	16	doi	doi	ADJ
admet-2455	1	17	:	:	PUNCT
admet-2455	1	18	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PROPN
admet-2455	1	19	821	821	NUM
admet-2455	1	20	admet	admet	NOUN
admet-2455	1	21	&	&	CCONJ
admet-2455	1	22	dmpk	dmpk	PROPN
admet-2455	1	23	12(6	12(6	NUM
admet-2455	1	24	)	)	PUNCT
admet-2455	1	25	(	(	PUNCT
admet-2455	1	26	2024	2024	NUM
admet-2455	1	27	)	)	PUNCT
admet-2455	1	28	821	821	NUM
admet-2455	1	29	-	-	SYM
admet-2455	1	30	841	841	NUM
admet-2455	1	31	;	;	PUNCT
admet-2455	1	32	doi	doi	NOUN
admet-2455	1	33	:	:	PUNCT
admet-2455	1	34	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	ADP
admet-2455	1	35	open	open	ADJ
admet-2455	1	36	access	access	NOUN
admet-2455	1	37	:	:	PUNCT
admet-2455	1	38	issn	issn	PROPN
admet-2455	1	39	:	:	PUNCT
admet-2455	1	40	1848	1848	NUM
admet-2455	1	41	-	-	SYM
admet-2455	1	42	7718	7718	NUM
admet-2455	1	43	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2455	1	44	original	original	ADJ
admet-2455	1	45	scientific	scientific	ADJ
admet-2455	1	46	paper	paper	NOUN
admet-2455	1	47	targeting	target	VERB
admet-2455	1	48	hexokinase	hexokinase	NOUN
admet-2455	1	49	2	2	NUM
admet-2455	1	50	to	to	PART
admet-2455	1	51	enhance	enhance	VERB
admet-2455	1	52	anticancer	anticancer	NOUN
admet-2455	1	53	efficacy	efficacy	NOUN
admet-2455	1	54	of	of	ADP
admet-2455	1	55	trichosanthin	trichosanthin	PROPN
admet-2455	1	56	in	in	ADP
admet-2455	1	57	hela	hela	PROPN
admet-2455	1	58	and	and	CCONJ
admet-2455	1	59	scc25	scc25	PROPN
admet-2455	1	60	cell	cell	NOUN
admet-2455	1	61	models	model	NOUN
admet-2455	1	62	yan	yan	PROPN
admet-2455	2	1	zhou1	zhou1	PROPN
admet-2455	2	2	,	,	PUNCT
admet-2455	2	3	maoxin	maoxin	NOUN
admet-2455	2	4	ran1	ran1	PROPN
admet-2455	2	5	,	,	PUNCT
admet-2455	2	6	wenying	wenye	VERB
admet-2455	2	7	shan1	shan1	PROPN
admet-2455	2	8	,	,	PUNCT
admet-2455	2	9	kaifang	kaifang	PROPN
admet-2455	2	10	wang1,2	wang1,2	PROPN
admet-2455	2	11	,	,	PUNCT
admet-2455	2	12	ou	ou	X
admet-2455	2	13	sha2	sha2	NOUN
admet-2455	2	14	,	,	PUNCT
admet-2455	2	15	*	*	PUNCT
admet-2455	2	16	and	and	CCONJ
admet-2455	2	17	kin	kin	PROPN
admet-2455	2	18	yip	yip	PROPN
admet-2455	2	19	tam1,	tam1,	PROPN
admet-2455	3	1	1faculty	1faculty	NUM
admet-2455	3	2	of	of	ADP
admet-2455	3	3	health	health	NOUN
admet-2455	3	4	sciences	sciences	PROPN
admet-2455	3	5	,	,	PUNCT
admet-2455	3	6	university	university	NOUN
admet-2455	3	7	of	of	ADP
admet-2455	3	8	macau	macau	PROPN
admet-2455	3	9	,	,	PUNCT
admet-2455	3	10	taipa	taipa	PROPN
admet-2455	3	11	,	,	PUNCT
admet-2455	3	12	macau	macau	PROPN
admet-2455	3	13	2school	2school	PROPN
admet-2455	3	14	of	of	ADP
admet-2455	3	15	dentistry	dentistry	NOUN
admet-2455	3	16	,	,	PUNCT
admet-2455	3	17	shenzhen	shenzhen	PROPN
admet-2455	3	18	university	university	PROPN
admet-2455	3	19	medical	medical	ADJ
admet-2455	3	20	school	school	PROPN
admet-2455	3	21	,	,	PUNCT
admet-2455	3	22	shenzhen	shenzhen	PROPN
admet-2455	3	23	,	,	PUNCT
admet-2455	3	24	china	china	PROPN
admet-2455	3	25	corresponding	correspond	VERB
admet-2455	3	26	authors	author	NOUN
admet-2455	3	27	:	:	PUNCT
admet-2455	4	1	e	e	X
admet-2455	4	2	-	-	NOUN
admet-2455	4	3	mail	mail	NOUN
admet-2455	4	4	:	:	PUNCT
admet-2455	4	5	*	*	PUNCT
admet-2455	4	6	shaou@szu.edu.cn	shaou@szu.edu.cn	NOUN
admet-2455	4	7	;	;	PUNCT
admet-2455	4	8	tel	tel	PROPN
admet-2455	4	9	.	.	PUNCT
admet-2455	4	10	:	:	PUNCT
admet-2455	5	1	+86	+86	PROPN
admet-2455	5	2	75586671916	75586671916	NUM
admet-2455	5	3	;	;	PUNCT
admet-2455	5	4	fax	fax	NOUN
admet-2455	5	5	:	:	PUNCT
admet-2455	5	6	+86	+86	PROPN
admet-2455	5	7	75586930182	75586930182	NUM
admet-2455	5	8	and	and	CCONJ
admet-2455	5	9	e	e	NOUN
admet-2455	5	10	-	-	PUNCT
admet-2455	5	11	mail	mail	NOUN
admet-2455	5	12	:	:	PUNCT
admet-2455	5	13	kintam@um.edu.mo	kintam@um.edu.mo	NOUN
admet-2455	5	14	;	;	PUNCT
admet-2455	5	15	tel	tel	PROPN
admet-2455	5	16	.	.	PUNCT
admet-2455	5	17	:	:	PUNCT
admet-2455	6	1	+853	+853	NOUN
admet-2455	6	2	88224988	88224988	NUM
admet-2455	6	3	;	;	PUNCT
admet-2455	6	4	fax	fax	NOUN
admet-2455	6	5	:	:	PUNCT
admet-2455	6	6	+853	+853	ADJ
admet-2455	6	7	88222314	88222314	NUM
admet-2455	6	8	received	receive	VERB
admet-2455	6	9	:	:	PUNCT
admet-2455	6	10	july	july	PROPN
admet-2455	6	11	15	15	NUM
admet-2455	6	12	,	,	PUNCT
admet-2455	6	13	2024	2024	NUM
admet-2455	6	14	;	;	PUNCT
admet-2455	6	15	revised	revise	VERB
admet-2455	6	16	:	:	PUNCT
admet-2455	6	17	september	september	PROPN
admet-2455	6	18	11	11	NUM
admet-2455	6	19	,	,	PUNCT
admet-2455	6	20	2024	2024	NUM
admet-2455	6	21	;	;	PUNCT
admet-2455	6	22	published	publish	VERB
admet-2455	6	23	:	:	PUNCT
admet-2455	6	24	september	september	PROPN
admet-2455	6	25	22	22	NUM
admet-2455	6	26	,	,	PUNCT
admet-2455	6	27	2024	2024	NUM
admet-2455	6	28	abstract	abstract	ADJ
admet-2455	6	29	background	background	NOUN
admet-2455	6	30	and	and	CCONJ
admet-2455	6	31	purpose	purpose	NOUN
admet-2455	6	32	:	:	PUNCT
admet-2455	6	33	trichosanthin	trichosanthin	PROPN
admet-2455	6	34	(	(	PUNCT
admet-2455	6	35	tcs	tcs	NOUN
admet-2455	6	36	)	)	PUNCT
admet-2455	6	37	is	be	AUX
admet-2455	6	38	a	a	DET
admet-2455	6	39	plant	plant	NOUN
admet-2455	6	40	-	-	PUNCT
admet-2455	6	41	based	base	VERB
admet-2455	6	42	ribosome	ribosome	NOUN
admet-2455	6	43	-	-	PUNCT
admet-2455	6	44	inactivating	inactivate	VERB
admet-2455	6	45	protein	protein	NOUN
admet-2455	6	46	exhibiting	exhibit	VERB
admet-2455	6	47	a	a	DET
admet-2455	6	48	range	range	NOUN
admet-2455	6	49	of	of	ADP
admet-2455	6	50	pharmacological	pharmacological	ADJ
admet-2455	6	51	properties	property	NOUN
admet-2455	6	52	,	,	PUNCT
admet-2455	6	53	including	include	VERB
admet-2455	6	54	abortifacient	abortifacient	NOUN
admet-2455	6	55	and	and	CCONJ
admet-2455	6	56	anticancer	anticancer	NOUN
admet-2455	6	57	.	.	PUNCT
admet-2455	7	1	however	however	ADV
admet-2455	7	2	,	,	PUNCT
admet-2455	7	3	the	the	DET
admet-2455	7	4	routine	routine	ADJ
admet-2455	7	5	clinical	clinical	ADJ
admet-2455	7	6	use	use	NOUN
admet-2455	7	7	in	in	ADP
admet-2455	7	8	cancer	cancer	NOUN
admet-2455	7	9	treatment	treatment	NOUN
admet-2455	7	10	was	be	AUX
admet-2455	7	11	hampered	hamper	VERB
admet-2455	7	12	by	by	ADP
admet-2455	7	13	its	its	PRON
admet-2455	7	14	antigenicity	antigenicity	NOUN
admet-2455	7	15	.	.	PUNCT
admet-2455	8	1	hexokinase	hexokinase	NOUN
admet-2455	8	2	2	2	NUM
admet-2455	8	3	(	(	PUNCT
admet-2455	8	4	hk2	hk2	X
admet-2455	8	5	)	)	PUNCT
admet-2455	8	6	is	be	AUX
admet-2455	8	7	a	a	DET
admet-2455	8	8	pivotal	pivotal	ADJ
admet-2455	8	9	regulator	regulator	NOUN
admet-2455	8	10	of	of	ADP
admet-2455	8	11	glycolysis	glycolysis	NOUN
admet-2455	8	12	,	,	PUNCT
admet-2455	8	13	where	where	SCONJ
admet-2455	8	14	aberrant	aberrant	ADJ
admet-2455	8	15	expression	expression	NOUN
admet-2455	8	16	is	be	AUX
admet-2455	8	17	observed	observe	VERB
admet-2455	8	18	in	in	ADP
admet-2455	8	19	many	many	ADJ
admet-2455	8	20	cancers	cancer	NOUN
admet-2455	8	21	.	.	PUNCT
admet-2455	9	1	this	this	DET
admet-2455	9	2	study	study	NOUN
admet-2455	9	3	investigates	investigate	VERB
admet-2455	9	4	the	the	DET
admet-2455	9	5	anticancer	anticancer	NOUN
admet-2455	9	6	effects	effect	NOUN
admet-2455	9	7	and	and	CCONJ
admet-2455	9	8	mechanisms	mechanism	NOUN
admet-2455	9	9	of	of	ADP
admet-2455	9	10	tcs	tcs	NOUN
admet-2455	9	11	in	in	ADP
admet-2455	9	12	combination	combination	NOUN
admet-2455	9	13	with	with	ADP
admet-2455	9	14	benserazide	benserazide	NOUN
admet-2455	9	15	(	(	PUNCT
admet-2455	9	16	benz	benz	PROPN
admet-2455	9	17	)	)	PUNCT
admet-2455	9	18	,	,	PUNCT
admet-2455	9	19	a	a	DET
admet-2455	9	20	hk2	hk2	NOUN
admet-2455	9	21	inhibitor	inhibitor	NOUN
admet-2455	9	22	,	,	PUNCT
admet-2455	9	23	in	in	ADP
admet-2455	9	24	hela	hela	PROPN
admet-2455	9	25	and	and	CCONJ
admet-2455	9	26	scc25	scc25	ADJ
admet-2455	9	27	cancer	cancer	NOUN
admet-2455	9	28	models	model	NOUN
admet-2455	9	29	.	.	PUNCT
admet-2455	10	1	experimental	experimental	ADJ
admet-2455	10	2	approach	approach	NOUN
admet-2455	10	3	:	:	PUNCT
admet-2455	10	4	mtt	mtt	NOUN
admet-2455	10	5	,	,	PUNCT
admet-2455	10	6	colony	colony	NOUN
admet-2455	10	7	-	-	PUNCT
admet-2455	10	8	formation	formation	NOUN
admet-2455	10	9	and	and	CCONJ
admet-2455	10	10	cell	cell	NOUN
admet-2455	10	11	cycle	cycle	NOUN
admet-2455	10	12	assays	assay	NOUN
admet-2455	10	13	were	be	AUX
admet-2455	10	14	performed	perform	VERB
admet-2455	10	15	to	to	PART
admet-2455	10	16	assess	assess	VERB
admet-2455	10	17	the	the	DET
admet-2455	10	18	cytotoxic	cytotoxic	ADJ
admet-2455	10	19	effects	effect	NOUN
admet-2455	10	20	of	of	ADP
admet-2455	10	21	tcs	tcs	NOUN
admet-2455	10	22	and	and	CCONJ
admet-2455	10	23	benz	benz	PROPN
admet-2455	10	24	in	in	ADP
admet-2455	10	25	hela	hela	PROPN
admet-2455	10	26	and	and	CCONJ
admet-2455	10	27	scc25	scc25	PROPN
admet-2455	10	28	cells	cell	NOUN
admet-2455	10	29	.	.	PUNCT
admet-2455	11	1	seahorse	seahorse	NOUN
admet-2455	11	2	assay	assay	PROPN
admet-2455	11	3	,	,	PUNCT
admet-2455	11	4	western	western	ADJ
admet-2455	11	5	blotting	blotting	NOUN
admet-2455	11	6	,	,	PUNCT
admet-2455	11	7	flow	flow	NOUN
admet-2455	11	8	cytometry	cytometry	NOUN
admet-2455	11	9	analysis	analysis	NOUN
admet-2455	11	10	and	and	CCONJ
admet-2455	11	11	rna	rna	NOUN
admet-2455	11	12	sequencing	sequencing	NOUN
admet-2455	11	13	were	be	AUX
admet-2455	11	14	employed	employ	VERB
admet-2455	11	15	to	to	PART
admet-2455	11	16	investigate	investigate	VERB
admet-2455	11	17	the	the	DET
admet-2455	11	18	pharmacological	pharmacological	ADJ
admet-2455	11	19	effects	effect	NOUN
admet-2455	11	20	of	of	ADP
admet-2455	11	21	the	the	DET
admet-2455	11	22	combo	combo	NOUN
admet-2455	11	23	treatment	treatment	NOUN
admet-2455	11	24	.	.	PUNCT
admet-2455	12	1	scc25	scc25	PROPN
admet-2455	12	2	cell	cell	PROPN
admet-2455	12	3	xenograft	xenograft	PROPN
admet-2455	12	4	mouse	mouse	PROPN
admet-2455	12	5	model	model	NOUN
admet-2455	12	6	was	be	AUX
admet-2455	12	7	established	establish	VERB
admet-2455	12	8	for	for	ADP
admet-2455	12	9	in	in	ADP
admet-2455	12	10	vivo	vivo	ADJ
admet-2455	12	11	efficacy	efficacy	NOUN
admet-2455	12	12	study	study	NOUN
admet-2455	12	13	.	.	PUNCT
admet-2455	13	1	key	key	ADJ
admet-2455	13	2	results	result	NOUN
admet-2455	13	3	:	:	PUNCT
admet-2455	13	4	combined	combined	ADJ
admet-2455	13	5	use	use	NOUN
admet-2455	13	6	of	of	ADP
admet-2455	13	7	tcs	tcs	PROPN
admet-2455	13	8	and	and	CCONJ
admet-2455	13	9	benz	benz	PROPN
admet-2455	13	10	exhibited	exhibit	VERB
admet-2455	13	11	synergistic	synergistic	ADJ
admet-2455	13	12	anticancer	anticancer	NOUN
admet-2455	13	13	effects	effect	NOUN
admet-2455	13	14	in	in	ADP
admet-2455	13	15	both	both	CCONJ
admet-2455	13	16	hela	hela	PROPN
admet-2455	13	17	and	and	CCONJ
admet-2455	13	18	scc25	scc25	PROPN
admet-2455	13	19	cell	cell	NOUN
admet-2455	13	20	models	model	NOUN
admet-2455	13	21	.	.	PUNCT
admet-2455	14	1	the	the	DET
admet-2455	14	2	observed	observe	VERB
admet-2455	14	3	synergistic	synergistic	ADJ
admet-2455	14	4	effects	effect	NOUN
admet-2455	14	5	were	be	AUX
admet-2455	14	6	attributed	attribute	VERB
admet-2455	14	7	to	to	ADP
admet-2455	14	8	the	the	DET
admet-2455	14	9	modulation	modulation	NOUN
admet-2455	14	10	of	of	ADP
admet-2455	14	11	glycolysis	glycolysis	NOUN
admet-2455	14	12	by	by	ADP
admet-2455	14	13	targeting	target	VERB
admet-2455	14	14	hk2	hk2	PROPN
admet-2455	14	15	,	,	PUNCT
admet-2455	14	16	leading	lead	VERB
admet-2455	14	17	to	to	ADP
admet-2455	14	18	reduced	reduce	VERB
admet-2455	14	19	lactate	lactate	NOUN
admet-2455	14	20	production	production	NOUN
admet-2455	14	21	and	and	CCONJ
admet-2455	14	22	increased	increase	VERB
admet-2455	14	23	ros	ros	PROPN
admet-2455	14	24	accumulation	accumulation	NOUN
admet-2455	14	25	which	which	PRON
admet-2455	14	26	further	far	ADV
admet-2455	14	27	inhibited	inhibit	VERB
admet-2455	14	28	colony	colony	NOUN
admet-2455	14	29	formation	formation	NOUN
admet-2455	14	30	and	and	CCONJ
admet-2455	14	31	cell	cell	NOUN
admet-2455	14	32	cycle	cycle	NOUN
admet-2455	14	33	progression	progression	NOUN
admet-2455	14	34	,	,	PUNCT
admet-2455	14	35	as	as	ADV
admet-2455	14	36	well	well	ADV
admet-2455	14	37	as	as	ADP
admet-2455	14	38	triggered	trigger	VERB
admet-2455	14	39	apoptosis	apoptosis	NOUN
admet-2455	14	40	.	.	PUNCT
admet-2455	15	1	moreover	moreover	ADV
admet-2455	15	2	,	,	PUNCT
admet-2455	15	3	this	this	DET
admet-2455	15	4	combination	combination	NOUN
admet-2455	15	5	effectively	effectively	ADV
admet-2455	15	6	inhibited	inhibit	VERB
admet-2455	15	7	nfκb	nfκb	PROPN
admet-2455	15	8	/	/	SYM
admet-2455	15	9	erk	erk	PROPN
admet-2455	15	10	signalling	signal	VERB
admet-2455	15	11	pathways	pathway	NOUN
admet-2455	15	12	,	,	PUNCT
admet-2455	15	13	which	which	PRON
admet-2455	15	14	were	be	AUX
admet-2455	15	15	found	find	VERB
admet-2455	15	16	to	to	PART
admet-2455	15	17	be	be	AUX
admet-2455	15	18	significantly	significantly	ADV
admet-2455	15	19	activated	activate	VERB
admet-2455	15	20	upon	upon	SCONJ
admet-2455	15	21	single	single	ADJ
admet-2455	15	22	use	use	NOUN
admet-2455	15	23	of	of	ADP
admet-2455	15	24	tcs	tcs	NOUN
admet-2455	15	25	.	.	PUNCT
admet-2455	16	1	it	it	PRON
admet-2455	16	2	was	be	AUX
admet-2455	16	3	found	find	VERB
admet-2455	16	4	that	that	SCONJ
admet-2455	16	5	the	the	DET
admet-2455	16	6	combination	combination	NOUN
admet-2455	16	7	significantly	significantly	ADV
admet-2455	16	8	suppressed	suppress	VERB
admet-2455	16	9	the	the	DET
admet-2455	16	10	tumour	tumour	NOUN
admet-2455	16	11	growth	growth	NOUN
admet-2455	16	12	in	in	ADP
admet-2455	16	13	scc25	scc25	PROPN
admet-2455	16	14	cell	cell	PROPN
admet-2455	16	15	xenograft	xenograft	PROPN
admet-2455	16	16	mouse	mouse	PROPN
admet-2455	16	17	model	model	NOUN
admet-2455	16	18	.	.	PUNCT
admet-2455	17	1	conclusion	conclusion	NOUN
admet-2455	17	2	:	:	PUNCT
admet-2455	17	3	our	our	PRON
admet-2455	17	4	findings	finding	NOUN
admet-2455	17	5	suggested	suggest	VERB
admet-2455	17	6	that	that	SCONJ
admet-2455	17	7	targeting	target	VERB
admet-2455	17	8	hk2	hk2	NOUN
admet-2455	17	9	and	and	CCONJ
admet-2455	17	10	modulating	modulate	VERB
admet-2455	17	11	glycolysis	glycolysis	NOUN
admet-2455	17	12	may	may	AUX
admet-2455	17	13	offer	offer	VERB
admet-2455	17	14	a	a	DET
admet-2455	17	15	promising	promising	ADJ
admet-2455	17	16	avenue	avenue	NOUN
admet-2455	17	17	for	for	ADP
admet-2455	17	18	improving	improve	VERB
admet-2455	17	19	the	the	DET
admet-2455	17	20	therapeutic	therapeutic	ADJ
admet-2455	17	21	outcomes	outcome	NOUN
admet-2455	17	22	of	of	ADP
admet-2455	17	23	tcs	tcs	NOUN
admet-2455	17	24	-	-	PUNCT
admet-2455	17	25	based	base	VERB
admet-2455	17	26	anticancer	anticancer	NOUN
admet-2455	17	27	treatments	treatment	NOUN
admet-2455	17	28	.	.	PUNCT
admet-2455	18	1	©	©	ADP
admet-2455	18	2	2024	2024	NUM
admet-2455	18	3	by	by	ADP
admet-2455	18	4	the	the	DET
admet-2455	18	5	authors	author	NOUN
admet-2455	18	6	.	.	PUNCT
admet-2455	19	1	this	this	DET
admet-2455	19	2	article	article	NOUN
admet-2455	19	3	is	be	AUX
admet-2455	19	4	an	an	DET
admet-2455	19	5	open	open	ADJ
admet-2455	19	6	-	-	PUNCT
admet-2455	19	7	access	access	NOUN
admet-2455	19	8	article	article	NOUN
admet-2455	19	9	distributed	distribute	VERB
admet-2455	19	10	under	under	ADP
admet-2455	19	11	the	the	DET
admet-2455	19	12	terms	term	NOUN
admet-2455	19	13	and	and	CCONJ
admet-2455	19	14	conditions	condition	NOUN
admet-2455	19	15	of	of	ADP
admet-2455	19	16	the	the	DET
admet-2455	19	17	creative	creative	ADJ
admet-2455	19	18	commons	common	NOUN
admet-2455	19	19	attribution	attribution	NOUN
admet-2455	19	20	license	license	NOUN
admet-2455	19	21	(	(	PUNCT
admet-2455	19	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2455	19	23	)	)	PUNCT
admet-2455	19	24	.	.	PUNCT
admet-2455	20	1	keywords	keyword	VERB
admet-2455	20	2	ribosome	ribosome	ADJ
admet-2455	20	3	-	-	PUNCT
admet-2455	20	4	inactivating	inactivate	VERB
admet-2455	20	5	protein	protein	NOUN
admet-2455	20	6	;	;	PUNCT
admet-2455	20	7	glycolysis	glycolysis	NOUN
admet-2455	20	8	;	;	PUNCT
admet-2455	20	9	drug	drug	NOUN
admet-2455	20	10	combination	combination	NOUN
admet-2455	20	11	;	;	PUNCT
admet-2455	20	12	synergistic	synergistic	ADJ
admet-2455	20	13	effect	effect	NOUN
admet-2455	20	14	;	;	PUNCT
admet-2455	20	15	cancer	cancer	NOUN
admet-2455	20	16	therapy	therapy	NOUN
admet-2455	20	17	introduction	introduction	NOUN
admet-2455	20	18	cancer	cancer	NOUN
admet-2455	20	19	,	,	PUNCT
admet-2455	20	20	characterized	characterize	VERB
admet-2455	20	21	by	by	ADP
admet-2455	20	22	uncontrolled	uncontrolled	ADJ
admet-2455	20	23	cell	cell	NOUN
admet-2455	20	24	growth	growth	NOUN
admet-2455	20	25	and	and	CCONJ
admet-2455	20	26	proliferation	proliferation	NOUN
admet-2455	20	27	,	,	PUNCT
admet-2455	20	28	is	be	AUX
admet-2455	20	29	one	one	NUM
admet-2455	20	30	of	of	ADP
admet-2455	20	31	the	the	DET
admet-2455	20	32	leading	lead	VERB
admet-2455	20	33	causes	cause	NOUN
admet-2455	20	34	of	of	ADP
admet-2455	20	35	death	death	NOUN
admet-2455	20	36	worldwide	worldwide	ADV
admet-2455	21	1	[	[	X
admet-2455	21	2	1	1	NUM
admet-2455	21	3	]	]	PUNCT
admet-2455	21	4	.	.	PUNCT
admet-2455	22	1	aberrant	aberrant	ADJ
admet-2455	22	2	cellular	cellular	ADJ
admet-2455	22	3	metabolism	metabolism	NOUN
admet-2455	22	4	has	have	AUX
admet-2455	22	5	been	be	AUX
admet-2455	22	6	recognized	recognize	VERB
admet-2455	22	7	as	as	ADP
admet-2455	22	8	a	a	DET
admet-2455	22	9	hallmark	hallmark	NOUN
admet-2455	22	10	of	of	ADP
admet-2455	22	11	cancer	cancer	NOUN
admet-2455	22	12	,	,	PUNCT
admet-2455	22	13	and	and	CCONJ
admet-2455	22	14	one	one	NUM
admet-2455	22	15	prominent	prominent	ADJ
admet-2455	22	16	metabolic	metabolic	NOUN
admet-2455	22	17	alteration	alteration	NOUN
admet-2455	22	18	is	be	AUX
admet-2455	22	19	the	the	DET
admet-2455	22	20	upregulation	upregulation	NOUN
admet-2455	22	21	of	of	ADP
admet-2455	22	22	glycolysis	glycolysis	NOUN
admet-2455	22	23	,	,	PUNCT
admet-2455	22	24	a	a	DET
admet-2455	22	25	phenomenon	phenomenon	NOUN
admet-2455	22	26	known	know	VERB
admet-2455	22	27	as	as	ADP
admet-2455	22	28	the	the	DET
admet-2455	22	29	warburg	warburg	NOUN
admet-2455	22	30	effect	effect	NOUN
admet-2455	22	31	,	,	PUNCT
admet-2455	22	32	which	which	PRON
admet-2455	22	33	involves	involve	VERB
admet-2455	22	34	increased	increase	VERB
admet-2455	22	35	glycolysis	glycolysis	NOUN
admet-2455	22	36	and	and	CCONJ
admet-2455	22	37	lactate	lactate	NOUN
admet-2455	22	38	production	production	NOUN
admet-2455	22	39	even	even	ADV
admet-2455	22	40	in	in	ADP
admet-2455	22	41	the	the	DET
admet-2455	22	42	presence	presence	NOUN
admet-2455	22	43	of	of	ADP
admet-2455	22	44	sufficient	sufficient	ADJ
admet-2455	22	45	oxygen	oxygen	NOUN
admet-2455	23	1	[	[	X
admet-2455	23	2	2,3	2,3	NUM
admet-2455	23	3	]	]	PUNCT
admet-2455	23	4	.	.	PUNCT
admet-2455	24	1	this	this	DET
admet-2455	24	2	metabolic	metabolic	NOUN
admet-2455	24	3	reprogramming	reprogramme	VERB
admet-2455	24	4	enables	enable	VERB
admet-2455	24	5	cancer	cancer	NOUN
admet-2455	24	6	cells	cell	NOUN
admet-2455	24	7	to	to	PART
admet-2455	24	8	sustain	sustain	VERB
admet-2455	24	9	their	their	PRON
admet-2455	24	10	energy	energy	NOUN
admet-2455	24	11	demands	demand	NOUN
admet-2455	24	12	and	and	CCONJ
admet-2455	24	13	support	support	VERB
admet-2455	24	14	rapid	rapid	ADJ
admet-2455	24	15	proliferation	proliferation	NOUN
admet-2455	24	16	[	[	X
admet-2455	24	17	4,5	4,5	NUM
admet-2455	24	18	]	]	PUNCT
admet-2455	24	19	.	.	PUNCT
admet-2455	25	1	hexokinase	hexokinase	NOUN
admet-2455	25	2	2	2	NUM
admet-2455	25	3	(	(	PUNCT
admet-2455	25	4	hk2	hk2	PROPN
admet-2455	25	5	)	)	PUNCT
admet-2455	25	6	,	,	PUNCT
admet-2455	25	7	a	a	DET
admet-2455	25	8	key	key	ADJ
admet-2455	25	9	enzyme	enzyme	NOUN
admet-2455	25	10	in	in	ADP
admet-2455	25	11	the	the	DET
admet-2455	25	12	glycolytic	glycolytic	ADJ
admet-2455	25	13	pathway	pathway	NOUN
admet-2455	25	14	,	,	PUNCT
admet-2455	25	15	plays	play	VERB
admet-2455	25	16	a	a	DET
admet-2455	25	17	critical	critical	ADJ
admet-2455	25	18	role	role	NOUN
admet-2455	25	19	in	in	ADP
admet-2455	25	20	facilitating	facilitate	VERB
admet-2455	25	21	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PROPN
admet-2455	25	22	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	ADP
admet-2455	26	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2455	26	2	mailto:shaou@szu.edu.cn	mailto:shaou@szu.edu.cn	NOUN
admet-2455	26	3	mailto:kintam@um.edu.mo	mailto:kintam@um.edu.mo	PROPN
admet-2455	26	4	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2455	26	5	y.	y.	PROPN
admet-2455	26	6	zhou	zhou	PROPN
admet-2455	26	7	et	et	PROPN
admet-2455	26	8	al	al	PROPN
admet-2455	26	9	.	.	PROPN
admet-2455	26	10	admet	admet	PROPN
admet-2455	26	11	&	&	CCONJ
admet-2455	26	12	dmpk	dmpk	PROPN
admet-2455	26	13	12(6	12(6	NUM
admet-2455	26	14	)	)	PUNCT
admet-2455	26	15	(	(	PUNCT
admet-2455	26	16	2024	2024	NUM
admet-2455	26	17	)	)	PUNCT
admet-2455	26	18	821	821	NUM
admet-2455	26	19	-	-	SYM
admet-2455	26	20	841	841	NUM
admet-2455	26	21	822	822	NUM
admet-2455	26	22	glucose	glucose	NOUN
admet-2455	26	23	metabolism	metabolism	NOUN
admet-2455	26	24	by	by	ADP
admet-2455	26	25	phosphorylating	phosphorylate	VERB
admet-2455	26	26	glucose	glucose	NOUN
admet-2455	26	27	to	to	ADP
admet-2455	26	28	glucose-6	glucose-6	NOUN
admet-2455	26	29	-	-	PUNCT
admet-2455	26	30	phosphate	phosphate	NOUN
admet-2455	26	31	,	,	PUNCT
admet-2455	26	32	initiating	initiate	VERB
admet-2455	26	33	its	its	PRON
admet-2455	26	34	entry	entry	NOUN
admet-2455	26	35	into	into	ADP
admet-2455	26	36	glycolysis	glycolysis	NOUN
admet-2455	26	37	pathway	pathway	NOUN
admet-2455	26	38	[	[	X
admet-2455	26	39	6	6	NUM
admet-2455	26	40	]	]	PUNCT
admet-2455	26	41	.	.	PUNCT
admet-2455	27	1	aberrant	aberrant	ADJ
admet-2455	27	2	upregulation	upregulation	NOUN
admet-2455	27	3	of	of	ADP
admet-2455	27	4	hk2	hk2	PROPN
admet-2455	27	5	has	have	AUX
admet-2455	27	6	been	be	AUX
admet-2455	27	7	observed	observe	VERB
admet-2455	27	8	in	in	ADP
admet-2455	27	9	various	various	ADJ
admet-2455	27	10	cancer	cancer	NOUN
admet-2455	27	11	types	type	NOUN
admet-2455	27	12	,	,	PUNCT
admet-2455	27	13	promoting	promote	VERB
admet-2455	27	14	tumour	tumour	NOUN
admet-2455	27	15	growth	growth	NOUN
admet-2455	27	16	,	,	PUNCT
admet-2455	27	17	progression	progression	NOUN
admet-2455	27	18	,	,	PUNCT
admet-2455	27	19	metastasis	metastasis	NOUN
admet-2455	27	20	,	,	PUNCT
admet-2455	27	21	and	and	CCONJ
admet-2455	27	22	drug	drug	NOUN
admet-2455	27	23	resistance	resistance	NOUN
admet-2455	27	24	[	[	X
admet-2455	27	25	7	7	NUM
admet-2455	27	26	]	]	PUNCT
admet-2455	27	27	.	.	PUNCT
admet-2455	28	1	inhibiting	inhibit	VERB
admet-2455	28	2	hk2	hk2	NOUN
admet-2455	28	3	activities	activity	NOUN
admet-2455	28	4	could	could	AUX
admet-2455	28	5	directly	directly	ADV
admet-2455	28	6	target	target	VERB
admet-2455	28	7	the	the	DET
admet-2455	28	8	metabolic	metabolic	NOUN
admet-2455	28	9	alterations	alteration	NOUN
admet-2455	28	10	in	in	ADP
admet-2455	28	11	cancer	cancer	NOUN
admet-2455	28	12	cells	cell	NOUN
admet-2455	28	13	,	,	PUNCT
admet-2455	28	14	particularly	particularly	ADV
admet-2455	28	15	disrupting	disrupt	VERB
admet-2455	28	16	the	the	DET
admet-2455	28	17	aberrantly	aberrantly	ADV
admet-2455	28	18	facilitated	facilitate	VERB
admet-2455	28	19	glycolysis	glycolysis	NOUN
admet-2455	28	20	.	.	PUNCT
admet-2455	29	1	this	this	DET
admet-2455	29	2	disruption	disruption	NOUN
admet-2455	29	3	can	can	AUX
admet-2455	29	4	lead	lead	VERB
admet-2455	29	5	to	to	ADP
admet-2455	29	6	a	a	DET
admet-2455	29	7	reduced	reduced	ADJ
admet-2455	29	8	availability	availability	NOUN
admet-2455	29	9	of	of	ADP
admet-2455	29	10	glycolytic	glycolytic	ADJ
admet-2455	29	11	intermediates	intermediate	NOUN
admet-2455	29	12	and	and	CCONJ
admet-2455	29	13	energy	energy	NOUN
admet-2455	29	14	production	production	NOUN
admet-2455	29	15	that	that	PRON
admet-2455	29	16	benefiting	benefit	VERB
admet-2455	29	17	cancer	cancer	NOUN
admet-2455	29	18	cell	cell	NOUN
admet-2455	29	19	proliferation	proliferation	NOUN
admet-2455	29	20	[	[	X
admet-2455	29	21	8	8	NUM
admet-2455	29	22	]	]	PUNCT
admet-2455	29	23	.	.	PUNCT
admet-2455	30	1	consequently	consequently	ADV
admet-2455	30	2	,	,	PUNCT
admet-2455	30	3	targeting	target	VERB
admet-2455	30	4	hk2	hk2	PROPN
admet-2455	30	5	has	have	AUX
admet-2455	30	6	emerged	emerge	VERB
admet-2455	30	7	as	as	ADP
admet-2455	30	8	a	a	DET
admet-2455	30	9	promising	promising	ADJ
admet-2455	30	10	adjunctive	adjunctive	ADJ
admet-2455	30	11	therapy	therapy	NOUN
admet-2455	30	12	to	to	PART
admet-2455	30	13	disrupt	disrupt	VERB
admet-2455	30	14	the	the	DET
admet-2455	30	15	metabolic	metabolic	NOUN
admet-2455	30	16	rewiring	rewiring	NOUN
admet-2455	30	17	of	of	ADP
admet-2455	30	18	cancer	cancer	NOUN
admet-2455	30	19	cells	cell	NOUN
admet-2455	30	20	[	[	X
admet-2455	30	21	9,10	9,10	NUM
admet-2455	30	22	]	]	PUNCT
admet-2455	30	23	.	.	PUNCT
admet-2455	31	1	recently	recently	ADV
admet-2455	31	2	,	,	PUNCT
admet-2455	31	3	there	there	PRON
admet-2455	31	4	has	have	AUX
admet-2455	31	5	been	be	AUX
admet-2455	31	6	a	a	DET
admet-2455	31	7	surge	surge	NOUN
admet-2455	31	8	of	of	ADP
admet-2455	31	9	interest	interest	NOUN
admet-2455	31	10	in	in	ADP
admet-2455	31	11	natural	natural	ADJ
admet-2455	31	12	compounds	compound	NOUN
admet-2455	31	13	as	as	ADP
admet-2455	31	14	potential	potential	ADJ
admet-2455	31	15	anticancer	anticancer	NOUN
admet-2455	31	16	agents	agent	NOUN
admet-2455	32	1	[	[	X
admet-2455	32	2	11,12	11,12	NUM
admet-2455	32	3	]	]	PUNCT
admet-2455	32	4	.	.	PUNCT
admet-2455	33	1	one	one	NUM
admet-2455	33	2	such	such	ADJ
admet-2455	33	3	bioactive	bioactive	NOUN
admet-2455	33	4	compound	compound	NOUN
admet-2455	33	5	is	be	AUX
admet-2455	33	6	trichosanthin	trichosanthin	ADJ
admet-2455	33	7	(	(	PUNCT
admet-2455	33	8	tcs	tcs	NOUN
admet-2455	33	9	)	)	PUNCT
admet-2455	33	10	,	,	PUNCT
admet-2455	33	11	which	which	PRON
admet-2455	33	12	derived	derive	VERB
admet-2455	33	13	from	from	ADP
admet-2455	33	14	the	the	DET
admet-2455	33	15	root	root	NOUN
admet-2455	33	16	tubers	tuber	NOUN
admet-2455	33	17	of	of	ADP
admet-2455	33	18	chinese	chinese	ADJ
admet-2455	33	19	medicinal	medicinal	ADJ
admet-2455	33	20	herb	herb	NOUN
admet-2455	33	21	trichosanthes	trichosanthe	VERB
admet-2455	33	22	kirilowii	kirilowii	NOUN
admet-2455	34	1	[	[	X
admet-2455	34	2	13	13	NUM
admet-2455	34	3	]	]	PUNCT
admet-2455	34	4	.	.	PUNCT
admet-2455	35	1	tcs	tcs	PROPN
admet-2455	35	2	possesses	possess	VERB
admet-2455	35	3	molecular	molecular	ADJ
admet-2455	35	4	weight	weight	NOUN
admet-2455	35	5	of	of	ADP
admet-2455	35	6	27	27	NUM
admet-2455	35	7	kda	kda	NOUN
admet-2455	35	8	and	and	CCONJ
admet-2455	35	9	is	be	AUX
admet-2455	35	10	composed	compose	VERB
admet-2455	35	11	of	of	ADP
admet-2455	35	12	a	a	DET
admet-2455	35	13	single	single	ADJ
admet-2455	35	14	polypeptide	polypeptide	ADJ
admet-2455	35	15	chain	chain	NOUN
admet-2455	35	16	containing	contain	VERB
admet-2455	35	17	247	247	NUM
admet-2455	35	18	amino	amino	NOUN
admet-2455	35	19	acid	acid	NOUN
admet-2455	35	20	residues	residue	NOUN
admet-2455	35	21	[	[	X
admet-2455	35	22	14	14	NUM
admet-2455	35	23	]	]	PUNCT
admet-2455	35	24	.	.	PUNCT
admet-2455	36	1	as	as	ADP
admet-2455	36	2	a	a	DET
admet-2455	36	3	type	type	NOUN
admet-2455	36	4	1	1	NUM
admet-2455	36	5	ribosome	ribosome	NOUN
admet-2455	36	6	-	-	PUNCT
admet-2455	36	7	inactivating	inactivate	VERB
admet-2455	36	8	protein	protein	NOUN
admet-2455	36	9	(	(	PUNCT
admet-2455	36	10	rip	rip	NOUN
admet-2455	36	11	)	)	PUNCT
admet-2455	36	12	,	,	PUNCT
admet-2455	36	13	tcs	tcs	NOUN
admet-2455	36	14	can	can	AUX
admet-2455	36	15	selectively	selectively	ADV
admet-2455	36	16	cleave	cleave	VERB
admet-2455	36	17	the	the	DET
admet-2455	36	18	conserved	conserve	VERB
admet-2455	36	19	sarcin	sarcin	NOUN
admet-2455	36	20	/	/	SYM
admet-2455	36	21	ricin	ricin	NOUN
admet-2455	36	22	loop	loop	NOUN
admet-2455	36	23	(	(	PUNCT
admet-2455	36	24	srl	srl	PROPN
admet-2455	36	25	)	)	PUNCT
admet-2455	36	26	in	in	ADP
admet-2455	36	27	the	the	DET
admet-2455	36	28	large	large	ADJ
admet-2455	36	29	ribosomal	ribosomal	NOUN
admet-2455	36	30	rna	rna	NOUN
admet-2455	36	31	(	(	PUNCT
admet-2455	36	32	rrna	rrna	NOUN
admet-2455	36	33	)	)	PUNCT
admet-2455	36	34	subunit	subunit	NOUN
admet-2455	36	35	,	,	PUNCT
admet-2455	36	36	which	which	PRON
admet-2455	36	37	leads	lead	VERB
admet-2455	36	38	to	to	ADP
admet-2455	36	39	the	the	DET
admet-2455	36	40	inhibition	inhibition	NOUN
admet-2455	36	41	of	of	ADP
admet-2455	36	42	protein	protein	NOUN
admet-2455	36	43	synthesis	synthesis	NOUN
admet-2455	36	44	,	,	PUNCT
admet-2455	36	45	ultimately	ultimately	ADV
admet-2455	36	46	resulting	result	VERB
admet-2455	36	47	in	in	ADP
admet-2455	36	48	cell	cell	NOUN
admet-2455	36	49	apoptosis	apoptosis	NOUN
admet-2455	36	50	[	[	X
admet-2455	36	51	15	15	NUM
admet-2455	36	52	]	]	PUNCT
admet-2455	36	53	.	.	PUNCT
admet-2455	37	1	tcs	tcs	PROPN
admet-2455	37	2	has	have	AUX
admet-2455	37	3	gained	gain	VERB
admet-2455	37	4	prominence	prominence	NOUN
admet-2455	37	5	for	for	ADP
admet-2455	37	6	its	its	PRON
admet-2455	37	7	in	in	X
admet-2455	37	8	vitro	vitro	X
admet-2455	37	9	and	and	CCONJ
admet-2455	37	10	in	in	ADP
admet-2455	37	11	vivo	vivo	ADJ
admet-2455	37	12	anticancer	anticancer	NOUN
admet-2455	37	13	properties	property	NOUN
admet-2455	37	14	by	by	ADP
admet-2455	37	15	demonstrating	demonstrate	VERB
admet-2455	37	16	multi	multi	ADJ
admet-2455	37	17	-	-	ADJ
admet-2455	37	18	faceted	faceted	ADJ
admet-2455	37	19	mechanisms	mechanism	NOUN
admet-2455	37	20	including	include	VERB
admet-2455	37	21	the	the	DET
admet-2455	37	22	inhibition	inhibition	NOUN
admet-2455	37	23	of	of	ADP
admet-2455	37	24	protein	protein	NOUN
admet-2455	37	25	synthesis	synthesis	NOUN
admet-2455	37	26	,	,	PUNCT
admet-2455	37	27	suppression	suppression	NOUN
admet-2455	37	28	of	of	ADP
admet-2455	37	29	tumour	tumour	NOUN
admet-2455	37	30	angiogenesis	angiogenesis	NOUN
admet-2455	37	31	,	,	PUNCT
admet-2455	37	32	triggering	trigger	VERB
admet-2455	37	33	apoptosis	apoptosis	NOUN
admet-2455	37	34	,	,	PUNCT
admet-2455	37	35	affecting	affect	VERB
admet-2455	37	36	cell	cell	NOUN
admet-2455	37	37	cycle	cycle	NOUN
admet-2455	37	38	,	,	PUNCT
admet-2455	37	39	and	and	CCONJ
admet-2455	37	40	modulating	modulate	VERB
admet-2455	37	41	immune	immune	ADJ
admet-2455	37	42	responses	response	NOUN
admet-2455	37	43	in	in	ADP
admet-2455	37	44	numerous	numerous	ADJ
admet-2455	37	45	types	type	NOUN
admet-2455	37	46	of	of	ADP
admet-2455	37	47	cancer	cancer	NOUN
admet-2455	37	48	cells	cell	NOUN
admet-2455	37	49	[	[	X
admet-2455	37	50	15	15	NUM
admet-2455	37	51	-	-	SYM
admet-2455	37	52	19	19	NUM
admet-2455	37	53	]	]	PUNCT
admet-2455	37	54	.	.	PUNCT
admet-2455	38	1	the	the	DET
admet-2455	38	2	multitude	multitude	NOUN
admet-2455	38	3	of	of	ADP
admet-2455	38	4	anticancer	anticancer	NOUN
admet-2455	38	5	properties	property	NOUN
admet-2455	38	6	makes	make	VERB
admet-2455	38	7	it	it	PRON
admet-2455	38	8	a	a	DET
admet-2455	38	9	potential	potential	ADJ
admet-2455	38	10	therapeutic	therapeutic	ADJ
admet-2455	38	11	candidate	candidate	NOUN
admet-2455	38	12	for	for	ADP
admet-2455	38	13	further	further	ADJ
admet-2455	38	14	research	research	NOUN
admet-2455	38	15	and	and	CCONJ
admet-2455	38	16	evaluation	evaluation	NOUN
admet-2455	38	17	.	.	PUNCT
admet-2455	39	1	despite	despite	SCONJ
admet-2455	39	2	the	the	DET
admet-2455	39	3	promising	promising	ADJ
admet-2455	39	4	potential	potential	NOUN
admet-2455	39	5	,	,	PUNCT
admet-2455	39	6	clinical	clinical	ADJ
admet-2455	39	7	adoption	adoption	NOUN
admet-2455	39	8	of	of	ADP
admet-2455	39	9	tcs	tcs	NOUN
admet-2455	39	10	as	as	ADP
admet-2455	39	11	a	a	DET
admet-2455	39	12	monotherapy	monotherapy	NOUN
admet-2455	39	13	to	to	ADP
admet-2455	39	14	anticancer	anticancer	NOUN
admet-2455	39	15	has	have	AUX
admet-2455	39	16	been	be	AUX
admet-2455	39	17	limited	limit	VERB
admet-2455	39	18	,	,	PUNCT
admet-2455	39	19	attributing	attribute	VERB
admet-2455	39	20	to	to	ADP
admet-2455	39	21	its	its	PRON
admet-2455	39	22	non	non	ADJ
admet-2455	39	23	-	-	NOUN
admet-2455	39	24	specificity	specificity	NOUN
admet-2455	39	25	and	and	CCONJ
admet-2455	39	26	the	the	DET
admet-2455	39	27	potential	potential	ADJ
admet-2455	39	28	toxicity	toxicity	NOUN
admet-2455	39	29	at	at	ADP
admet-2455	39	30	high	high	ADJ
admet-2455	39	31	doses	dose	NOUN
admet-2455	39	32	[	[	X
admet-2455	39	33	15,20	15,20	NUM
admet-2455	39	34	]	]	X
admet-2455	39	35	.	.	PUNCT
admet-2455	40	1	therefore	therefore	ADV
admet-2455	40	2	,	,	PUNCT
admet-2455	40	3	it	it	PRON
admet-2455	40	4	would	would	AUX
admet-2455	40	5	be	be	AUX
admet-2455	40	6	of	of	ADP
admet-2455	40	7	great	great	ADJ
admet-2455	40	8	interest	interest	NOUN
admet-2455	40	9	to	to	PART
admet-2455	40	10	develop	develop	VERB
admet-2455	40	11	novel	novel	ADJ
admet-2455	40	12	strategies	strategy	NOUN
admet-2455	40	13	for	for	ADP
admet-2455	40	14	enhancing	enhance	VERB
admet-2455	40	15	the	the	DET
admet-2455	40	16	anticancer	anticancer	NOUN
admet-2455	40	17	effects	effect	NOUN
admet-2455	40	18	of	of	ADP
admet-2455	40	19	tcs	tcs	NOUN
admet-2455	40	20	while	while	SCONJ
admet-2455	40	21	lowering	lower	VERB
admet-2455	40	22	the	the	DET
admet-2455	40	23	efficacious	efficacious	ADJ
admet-2455	40	24	dose	dose	NOUN
admet-2455	40	25	to	to	PART
admet-2455	40	26	minimize	minimize	VERB
admet-2455	40	27	toxic	toxic	ADJ
admet-2455	40	28	effects	effect	NOUN
admet-2455	40	29	,	,	PUNCT
admet-2455	40	30	which	which	PRON
admet-2455	40	31	may	may	AUX
admet-2455	40	32	facilitate	facilitate	VERB
admet-2455	40	33	successful	successful	ADJ
admet-2455	40	34	clinical	clinical	ADJ
admet-2455	40	35	translation	translation	NOUN
admet-2455	40	36	.	.	PUNCT
admet-2455	41	1	to	to	ADP
admet-2455	41	2	date	date	NOUN
admet-2455	41	3	,	,	PUNCT
admet-2455	41	4	several	several	ADJ
admet-2455	41	5	studies	study	NOUN
admet-2455	41	6	have	have	AUX
admet-2455	41	7	indicated	indicate	VERB
admet-2455	41	8	that	that	SCONJ
admet-2455	41	9	tcs	tcs	NOUN
admet-2455	41	10	could	could	AUX
admet-2455	41	11	be	be	AUX
admet-2455	41	12	utilized	utilize	VERB
admet-2455	41	13	as	as	ADP
admet-2455	41	14	a	a	DET
admet-2455	41	15	constituent	constituent	NOUN
admet-2455	41	16	of	of	ADP
admet-2455	41	17	a	a	DET
admet-2455	41	18	drug	drug	NOUN
admet-2455	41	19	cocktail	cocktail	NOUN
admet-2455	41	20	or	or	CCONJ
admet-2455	41	21	combination	combination	NOUN
admet-2455	41	22	therapy	therapy	NOUN
admet-2455	41	23	to	to	PART
admet-2455	41	24	boost	boost	VERB
admet-2455	41	25	its	its	PRON
admet-2455	41	26	efficacy	efficacy	NOUN
admet-2455	42	1	[	[	X
admet-2455	42	2	21	21	NUM
admet-2455	42	3	-	-	SYM
admet-2455	42	4	23	23	NUM
admet-2455	42	5	]	]	PUNCT
admet-2455	42	6	.	.	PUNCT
admet-2455	43	1	it	it	PRON
admet-2455	43	2	has	have	AUX
admet-2455	43	3	been	be	AUX
admet-2455	43	4	reported	report	VERB
admet-2455	43	5	that	that	SCONJ
admet-2455	43	6	tcs	tcs	NOUN
admet-2455	43	7	synergized	synergize	VERB
admet-2455	43	8	imatinib	imatinib	NOUN
admet-2455	43	9	to	to	PART
admet-2455	43	10	suppress	suppress	VERB
admet-2455	43	11	the	the	DET
admet-2455	43	12	nf	nf	ADJ
admet-2455	43	13	-	-	PUNCT
admet-2455	43	14	κb	κb	NOUN
admet-2455	43	15	signaling	signal	VERB
admet-2455	43	16	pathway	pathway	NOUN
admet-2455	43	17	resulting	result	VERB
admet-2455	43	18	in	in	ADP
admet-2455	43	19	enhanced	enhanced	ADJ
admet-2455	43	20	inhibitory	inhibitory	ADJ
admet-2455	43	21	effects	effect	NOUN
admet-2455	43	22	in	in	ADP
admet-2455	43	23	chronic	chronic	ADJ
admet-2455	43	24	granulocytic	granulocytic	ADJ
admet-2455	43	25	lineage	lineage	NOUN
admet-2455	43	26	leukaemia	leukaemia	NOUN
admet-2455	43	27	cells	cell	NOUN
admet-2455	43	28	[	[	X
admet-2455	43	29	24	24	NUM
admet-2455	43	30	]	]	PUNCT
admet-2455	43	31	.	.	PUNCT
admet-2455	44	1	as	as	ADV
admet-2455	44	2	far	far	ADV
admet-2455	44	3	as	as	SCONJ
admet-2455	44	4	we	we	PRON
admet-2455	44	5	are	be	AUX
admet-2455	44	6	aware	aware	ADJ
admet-2455	44	7	,	,	PUNCT
admet-2455	44	8	little	little	ADJ
admet-2455	44	9	,	,	PUNCT
admet-2455	44	10	if	if	SCONJ
admet-2455	44	11	any	any	PRON
admet-2455	44	12	,	,	PUNCT
admet-2455	44	13	work	work	NOUN
admet-2455	44	14	had	have	AUX
admet-2455	44	15	been	be	AUX
admet-2455	44	16	undertaken	undertake	VERB
admet-2455	44	17	to	to	PART
admet-2455	44	18	explore	explore	VERB
admet-2455	44	19	the	the	DET
admet-2455	44	20	anticancer	anticancer	NOUN
admet-2455	44	21	effects	effect	NOUN
admet-2455	44	22	in	in	ADP
admet-2455	44	23	the	the	DET
admet-2455	44	24	combined	combine	VERB
admet-2455	44	25	use	use	NOUN
admet-2455	44	26	of	of	ADP
admet-2455	44	27	tcs	tcs	NOUN
admet-2455	44	28	and	and	CCONJ
admet-2455	44	29	hk2	hk2	VERB
admet-2455	44	30	inhibitor	inhibitor	NOUN
admet-2455	44	31	.	.	PUNCT
admet-2455	45	1	in	in	ADP
admet-2455	45	2	the	the	DET
admet-2455	45	3	present	present	ADJ
admet-2455	45	4	study	study	NOUN
admet-2455	45	5	,	,	PUNCT
admet-2455	45	6	we	we	PRON
admet-2455	45	7	explore	explore	VERB
admet-2455	45	8	the	the	DET
admet-2455	45	9	innovative	innovative	ADJ
admet-2455	45	10	and	and	CCONJ
admet-2455	45	11	rational	rational	ADJ
admet-2455	45	12	combination	combination	NOUN
admet-2455	45	13	of	of	ADP
admet-2455	45	14	tcs	tcs	NOUN
admet-2455	45	15	with	with	ADP
admet-2455	45	16	benserazide	benserazide	ADJ
admet-2455	45	17	hydrochloride	hydrochloride	NOUN
admet-2455	45	18	(	(	PUNCT
admet-2455	45	19	benz	benz	PROPN
admet-2455	45	20	)	)	PUNCT
admet-2455	45	21	,	,	PUNCT
admet-2455	45	22	a	a	DET
admet-2455	45	23	hk2	hk2	NOUN
admet-2455	45	24	inhibitor	inhibitor	NOUN
admet-2455	45	25	,	,	PUNCT
admet-2455	45	26	using	use	VERB
admet-2455	45	27	hela	hela	PROPN
admet-2455	45	28	(	(	PUNCT
admet-2455	45	29	human	human	ADJ
admet-2455	45	30	cervical	cervical	ADJ
admet-2455	45	31	cancer	cancer	NOUN
admet-2455	45	32	)	)	PUNCT
admet-2455	45	33	and	and	CCONJ
admet-2455	45	34	scc25	scc25	PROPN
admet-2455	45	35	(	(	PUNCT
admet-2455	45	36	human	human	ADJ
admet-2455	45	37	oral	oral	ADJ
admet-2455	45	38	squamous	squamous	ADJ
admet-2455	45	39	cell	cell	NOUN
admet-2455	45	40	carcinoma	carcinoma	NOUN
admet-2455	45	41	)	)	PUNCT
admet-2455	45	42	cells	cell	NOUN
admet-2455	45	43	as	as	ADP
admet-2455	45	44	cancer	cancer	NOUN
admet-2455	45	45	models	model	NOUN
admet-2455	45	46	.	.	PUNCT
admet-2455	46	1	as	as	ADP
admet-2455	46	2	a	a	DET
admet-2455	46	3	food	food	NOUN
admet-2455	46	4	&	&	CCONJ
admet-2455	46	5	drug	drug	PROPN
admet-2455	46	6	administration	administration	PROPN
admet-2455	46	7	(	(	PUNCT
admet-2455	46	8	fda	fda	PROPN
admet-2455	46	9	)	)	PUNCT
admet-2455	46	10	approved	approve	VERB
admet-2455	46	11	compound	compound	NOUN
admet-2455	46	12	used	use	VERB
admet-2455	46	13	along	along	ADP
admet-2455	46	14	with	with	ADP
admet-2455	46	15	levodopa	levodopa	NOUN
admet-2455	46	16	to	to	PART
admet-2455	46	17	treat	treat	VERB
admet-2455	46	18	parkinson	parkinson	NOUN
admet-2455	46	19	’s	’s	PART
admet-2455	46	20	disease	disease	NOUN
admet-2455	46	21	,	,	PUNCT
admet-2455	46	22	benz	benz	PROPN
admet-2455	46	23	was	be	AUX
admet-2455	46	24	previously	previously	ADV
admet-2455	46	25	reported	report	VERB
admet-2455	46	26	to	to	PART
admet-2455	46	27	block	block	VERB
admet-2455	46	28	hk2	hk2	VERB
admet-2455	46	29	enzymatic	enzymatic	ADJ
admet-2455	46	30	activity	activity	NOUN
admet-2455	46	31	with	with	ADP
admet-2455	46	32	tolerable	tolerable	ADJ
admet-2455	46	33	toxicity	toxicity	NOUN
admet-2455	46	34	[	[	X
admet-2455	46	35	25	25	NUM
admet-2455	46	36	]	]	PUNCT
admet-2455	46	37	.	.	PUNCT
admet-2455	47	1	by	by	ADP
admet-2455	47	2	combining	combine	VERB
admet-2455	47	3	tcs	tcs	PROPN
admet-2455	47	4	with	with	ADP
admet-2455	47	5	benz	benz	PROPN
admet-2455	47	6	,	,	PUNCT
admet-2455	47	7	we	we	PRON
admet-2455	47	8	seek	seek	VERB
admet-2455	47	9	to	to	PART
admet-2455	47	10	evaluate	evaluate	VERB
admet-2455	47	11	the	the	DET
admet-2455	47	12	anticancer	anticancer	NOUN
admet-2455	47	13	synergism	synergism	NOUN
admet-2455	47	14	,	,	PUNCT
admet-2455	47	15	assess	assess	VERB
admet-2455	47	16	the	the	DET
admet-2455	47	17	metabolic	metabolic	NOUN
admet-2455	47	18	alterations	alteration	NOUN
admet-2455	47	19	,	,	PUNCT
admet-2455	47	20	and	and	CCONJ
admet-2455	47	21	investigate	investigate	VERB
admet-2455	47	22	the	the	DET
admet-2455	47	23	molecular	molecular	ADJ
admet-2455	47	24	mechanisms	mechanism	NOUN
admet-2455	47	25	in	in	ADP
admet-2455	47	26	response	response	NOUN
admet-2455	47	27	to	to	ADP
admet-2455	47	28	the	the	DET
admet-2455	47	29	designed	design	VERB
admet-2455	47	30	combination	combination	NOUN
admet-2455	47	31	regimen	regiman	NOUN
admet-2455	47	32	.	.	PUNCT
admet-2455	48	1	experimental	experimental	ADJ
admet-2455	48	2	cell	cell	NOUN
admet-2455	48	3	lines	line	NOUN
admet-2455	48	4	and	and	CCONJ
admet-2455	48	5	cell	cell	NOUN
admet-2455	48	6	culture	culture	NOUN
admet-2455	48	7	hela	hela	PROPN
admet-2455	48	8	and	and	CCONJ
admet-2455	48	9	scc25	scc25	PROPN
admet-2455	48	10	cell	cell	NOUN
admet-2455	48	11	lines	line	NOUN
admet-2455	48	12	were	be	AUX
admet-2455	48	13	purchased	purchase	VERB
admet-2455	48	14	from	from	ADP
admet-2455	48	15	the	the	DET
admet-2455	48	16	american	american	ADJ
admet-2455	48	17	type	type	NOUN
admet-2455	48	18	culture	culture	NOUN
admet-2455	48	19	collection	collection	NOUN
admet-2455	48	20	.	.	PUNCT
admet-2455	49	1	human	human	ADJ
admet-2455	49	2	fibroblast	fibroblast	ADJ
admet-2455	49	3	cell	cell	NOUN
admet-2455	49	4	line	line	NOUN
admet-2455	49	5	was	be	AUX
admet-2455	49	6	a	a	DET
admet-2455	49	7	gift	gift	NOUN
admet-2455	49	8	from	from	ADP
admet-2455	49	9	prof	prof	PROPN
admet-2455	49	10	.	.	PUNCT
admet-2455	50	1	guokai	guokai	PROPN
admet-2455	50	2	chen	chen	PROPN
admet-2455	50	3	(	(	PUNCT
admet-2455	50	4	faculty	faculty	NOUN
admet-2455	50	5	of	of	ADP
admet-2455	50	6	health	health	NOUN
admet-2455	50	7	sciences	sciences	PROPN
admet-2455	50	8	,	,	PUNCT
admet-2455	50	9	university	university	NOUN
admet-2455	50	10	of	of	ADP
admet-2455	50	11	macau	macau	PROPN
admet-2455	50	12	)	)	PUNCT
admet-2455	50	13	.	.	PUNCT
admet-2455	51	1	all	all	DET
admet-2455	51	2	cells	cell	NOUN
admet-2455	51	3	were	be	AUX
admet-2455	51	4	grown	grow	VERB
admet-2455	51	5	in	in	ADP
admet-2455	51	6	full	full	ADJ
admet-2455	51	7	media	medium	NOUN
admet-2455	51	8	containing	contain	VERB
admet-2455	51	9	dmem	dmem	ADJ
admet-2455	51	10	(	(	PUNCT
admet-2455	51	11	gibco	gibco	NOUN
admet-2455	51	12	,	,	PUNCT
admet-2455	51	13	thermo	thermo	NOUN
admet-2455	51	14	fisher	fisher	PROPN
admet-2455	51	15	scientific	scientific	PROPN
admet-2455	51	16	,	,	PUNCT
admet-2455	51	17	usa	usa	PROPN
admet-2455	51	18	)	)	PUNCT
admet-2455	51	19	with	with	ADP
admet-2455	51	20	10	10	NUM
admet-2455	51	21	%	%	NOUN
admet-2455	51	22	fetal	fetal	ADJ
admet-2455	51	23	bovine	bovine	NOUN
admet-2455	51	24	serum	serum	NOUN
admet-2455	51	25	(	(	PUNCT
admet-2455	51	26	fbs	fbs	PROPN
admet-2455	51	27	)	)	PUNCT
admet-2455	51	28	,	,	PUNCT
admet-2455	51	29	maintained	maintain	VERB
admet-2455	51	30	in	in	ADP
admet-2455	51	31	a	a	DET
admet-2455	51	32	37	37	NUM
admet-2455	51	33	°	°	NOUN
admet-2455	51	34	c	c	NOUN
admet-2455	51	35	,	,	PUNCT
admet-2455	51	36	5	5	NUM
admet-2455	51	37	%	%	NOUN
admet-2455	51	38	co2	co2	NOUN
admet-2455	51	39	atmosphere	atmosphere	NOUN
admet-2455	51	40	incubator	incubator	NOUN
admet-2455	51	41	.	.	PUNCT
admet-2455	52	1	materials	material	NOUN
admet-2455	52	2	tcs	tcs	NOUN
admet-2455	52	3	was	be	AUX
admet-2455	52	4	prepared	prepare	VERB
admet-2455	52	5	by	by	ADP
admet-2455	52	6	molecular	molecular	ADJ
admet-2455	52	7	cloning	cloning	NOUN
admet-2455	52	8	as	as	SCONJ
admet-2455	52	9	previously	previously	ADV
admet-2455	52	10	described	describe	VERB
admet-2455	52	11	[	[	X
admet-2455	52	12	18	18	NUM
admet-2455	52	13	]	]	PUNCT
admet-2455	52	14	.	.	PUNCT
admet-2455	53	1	benz	benz	PROPN
admet-2455	53	2	was	be	AUX
admet-2455	53	3	purchased	purchase	VERB
admet-2455	53	4	from	from	ADP
admet-2455	53	5	aladdin	aladdin	VERB
admet-2455	53	6	(	(	PUNCT
admet-2455	53	7	shanghai	shanghai	PROPN
admet-2455	53	8	,	,	PUNCT
admet-2455	53	9	china	china	PROPN
admet-2455	53	10	)	)	PUNCT
admet-2455	53	11	.	.	PUNCT
admet-2455	54	1	primary	primary	ADJ
admet-2455	54	2	antibodies	antibody	NOUN
admet-2455	54	3	against	against	ADP
admet-2455	54	4	hexokinase	hexokinase	PROPN
admet-2455	54	5	ii	ii	PROPN
admet-2455	54	6	(	(	PUNCT
admet-2455	54	7	c64g5	c64g5	PROPN
admet-2455	54	8	)	)	PUNCT
admet-2455	54	9	(	(	PUNCT
admet-2455	54	10	cat#2867	cat#2867	NOUN
admet-2455	54	11	)	)	PUNCT
admet-2455	54	12	,	,	PUNCT
admet-2455	54	13	nf	nf	ADJ
admet-2455	54	14	-	-	PUNCT
admet-2455	54	15	κb	κb	ADJ
admet-2455	54	16	p65	p65	NOUN
admet-2455	54	17	(	(	PUNCT
admet-2455	54	18	d14e12	d14e12	NOUN
admet-2455	54	19	)	)	PUNCT
admet-2455	54	20	admet	admet	PROPN
admet-2455	54	21	&	&	CCONJ
admet-2455	54	22	dmpk	dmpk	PROPN
admet-2455	54	23	12(6	12(6	NUM
admet-2455	54	24	)	)	PUNCT
admet-2455	54	25	(	(	PUNCT
admet-2455	54	26	2024	2024	NUM
admet-2455	54	27	)	)	PUNCT
admet-2455	54	28	821	821	NUM
admet-2455	54	29	-	-	SYM
admet-2455	54	30	841	841	NUM
admet-2455	54	31	targeting	targeting	NOUN
admet-2455	54	32	hexokinase	hexokinase	NOUN
admet-2455	54	33	2	2	NUM
admet-2455	54	34	to	to	PART
admet-2455	54	35	enhance	enhance	VERB
admet-2455	54	36	anticancer	anticancer	NOUN
admet-2455	54	37	efficacy	efficacy	NOUN
admet-2455	54	38	of	of	ADP
admet-2455	54	39	trichosanthin	trichosanthin	PROPN
admet-2455	54	40	doi	doi	PROPN
admet-2455	54	41	:	:	PUNCT
admet-2455	54	42	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	ADP
admet-2455	54	43	823	823	NUM
admet-2455	54	44	(	(	PUNCT
admet-2455	54	45	cat#8	cat#8	PROPN
admet-2455	54	46	242	242	NUM
admet-2455	54	47	)	)	PUNCT
admet-2455	54	48	,	,	PUNCT
admet-2455	54	49	phospho	phospho	ADJ
admet-2455	54	50	-	-	PUNCT
admet-2455	54	51	nf	nf	NOUN
admet-2455	54	52	-	-	PUNCT
admet-2455	54	53	κb	κb	ADJ
admet-2455	54	54	p65	p65	NOUN
admet-2455	54	55	(	(	PUNCT
admet-2455	54	56	ser536	ser536	NOUN
admet-2455	54	57	)	)	PUNCT
admet-2455	54	58	(	(	PUNCT
admet-2455	54	59	93h1	93h1	NUM
admet-2455	54	60	)	)	PUNCT
admet-2455	54	61	(	(	PUNCT
admet-2455	54	62	cat#3033	cat#3033	PROPN
admet-2455	54	63	)	)	PUNCT
admet-2455	54	64	,	,	PUNCT
admet-2455	54	65	p44/42	p44/42	PROPN
admet-2455	54	66	mapk	mapk	NOUN
admet-2455	54	67	(	(	PUNCT
admet-2455	54	68	erk1/2	erk1/2	PROPN
admet-2455	54	69	)	)	PUNCT
admet-2455	54	70	(	(	PUNCT
admet-2455	54	71	cat#9102	cat#9102	NOUN
admet-2455	54	72	)	)	PUNCT
admet-2455	54	73	,	,	PUNCT
admet-2455	54	74	phosphop44/42	phosphop44/42	NOUN
admet-2455	54	75	mapk	mapk	NOUN
admet-2455	54	76	(	(	PUNCT
admet-2455	54	77	erk1/2	erk1/2	PROPN
admet-2455	54	78	)	)	PUNCT
admet-2455	54	79	(	(	PUNCT
admet-2455	54	80	thr202	thr202	PROPN
admet-2455	54	81	/	/	SYM
admet-2455	54	82	tyr204	tyr204	PROPN
admet-2455	54	83	)	)	PUNCT
admet-2455	54	84	(	(	PUNCT
admet-2455	54	85	cat#9101	cat#9101	NOUN
admet-2455	54	86	)	)	PUNCT
admet-2455	54	87	,	,	PUNCT
admet-2455	54	88	caspase-3	caspase-3	PROPN
admet-2455	54	89	(	(	PUNCT
admet-2455	54	90	cat#9662	cat#9662	NOUN
admet-2455	54	91	)	)	PUNCT
admet-2455	54	92	,	,	PUNCT
admet-2455	54	93	cleaved	cleave	VERB
admet-2455	54	94	caspase-3	caspase-3	PROPN
admet-2455	54	95	(	(	PUNCT
admet-2455	54	96	asp175	asp175	PROPN
admet-2455	54	97	)	)	PUNCT
admet-2455	54	98	(	(	PUNCT
admet-2455	54	99	cat#9661	cat#9661	NUM
admet-2455	54	100	)	)	PUNCT
admet-2455	54	101	,	,	PUNCT
admet-2455	54	102	and	and	CCONJ
admet-2455	54	103	β	β	X
admet-2455	54	104	-	-	NOUN
admet-2455	54	105	actin	actin	NOUN
admet-2455	54	106	(	(	PUNCT
admet-2455	54	107	cat#4967s	cat#4967s	PROPN
admet-2455	54	108	)	)	PUNCT
admet-2455	54	109	were	be	AUX
admet-2455	54	110	purchased	purchase	VERB
admet-2455	54	111	from	from	ADP
admet-2455	54	112	cell	cell	NOUN
admet-2455	54	113	signaling	signal	VERB
admet-2455	54	114	technology	technology	NOUN
admet-2455	54	115	(	(	PUNCT
admet-2455	54	116	cst	cst	PROPN
admet-2455	54	117	,	,	PUNCT
admet-2455	54	118	usa	usa	PROPN
admet-2455	54	119	)	)	PUNCT
admet-2455	54	120	.	.	PUNCT
admet-2455	55	1	pcna	pcna	PROPN
admet-2455	55	2	antibody	antibody	NOUN
admet-2455	55	3	(	(	PUNCT
admet-2455	55	4	pc10	pc10	PROPN
admet-2455	55	5	)	)	PUNCT
admet-2455	55	6	(	(	PUNCT
admet-2455	55	7	cat#sc-56	cat#sc-56	PROPN
admet-2455	55	8	)	)	PUNCT
admet-2455	55	9	was	be	AUX
admet-2455	55	10	purchased	purchase	VERB
admet-2455	55	11	from	from	ADP
admet-2455	55	12	santa	santa	PROPN
admet-2455	55	13	cruz	cruz	PROPN
admet-2455	55	14	biotechnology	biotechnology	PROPN
admet-2455	55	15	(	(	PUNCT
admet-2455	55	16	scbt	scbt	PROPN
admet-2455	55	17	,	,	PUNCT
admet-2455	55	18	santa	santa	PROPN
admet-2455	55	19	cruz	cruz	PROPN
admet-2455	55	20	,	,	PUNCT
admet-2455	55	21	ca	ca	PROPN
admet-2455	55	22	,	,	PUNCT
admet-2455	55	23	usa	usa	PROPN
admet-2455	55	24	)	)	PUNCT
admet-2455	55	25	.	.	PUNCT
admet-2455	56	1	the	the	DET
admet-2455	56	2	secondary	secondary	ADJ
admet-2455	56	3	antibodies	antibodie	VERB
admet-2455	56	4	anti	anti	ADJ
admet-2455	56	5	-	-	ADJ
admet-2455	56	6	mouse	mouse	ADJ
admet-2455	56	7	igg	igg	PROPN
admet-2455	56	8	,	,	PUNCT
admet-2455	56	9	hrp	hrp	NOUN
admet-2455	56	10	-	-	PUNCT
admet-2455	56	11	linked	link	VERB
admet-2455	56	12	antibody	antibody	NOUN
admet-2455	56	13	(	(	PUNCT
admet-2455	56	14	cat#7076	cat#7076	PROPN
admet-2455	56	15	)	)	PUNCT
admet-2455	56	16	and	and	CCONJ
admet-2455	56	17	anti	anti	ADJ
admet-2455	56	18	-	-	ADJ
admet-2455	56	19	rabbit	rabbit	ADJ
admet-2455	56	20	igg	igg	PROPN
admet-2455	56	21	,	,	PUNCT
admet-2455	56	22	hrp	hrp	NOUN
admet-2455	56	23	-	-	PUNCT
admet-2455	56	24	linked	link	VERB
admet-2455	56	25	antibody	antibody	NOUN
admet-2455	56	26	(	(	PUNCT
admet-2455	56	27	cat#7074	cat#7074	PROPN
admet-2455	56	28	)	)	PUNCT
admet-2455	56	29	were	be	AUX
admet-2455	56	30	purchased	purchase	VERB
admet-2455	56	31	from	from	ADP
admet-2455	56	32	cell	cell	NOUN
admet-2455	56	33	signalling	signal	VERB
admet-2455	56	34	technology	technology	NOUN
admet-2455	56	35	(	(	PUNCT
admet-2455	56	36	cst	cst	PROPN
admet-2455	56	37	,	,	PUNCT
admet-2455	56	38	usa	usa	PROPN
admet-2455	56	39	)	)	PUNCT
admet-2455	56	40	.	.	PUNCT
admet-2455	57	1	cell	cell	NOUN
admet-2455	57	2	viability	viability	NOUN
admet-2455	57	3	mtt	mtt	NOUN
admet-2455	57	4	assay	assay	NOUN
admet-2455	57	5	cells	cell	NOUN
admet-2455	57	6	were	be	AUX
admet-2455	57	7	seeded	seed	VERB
admet-2455	57	8	onto	onto	ADP
admet-2455	57	9	96	96	NUM
admet-2455	57	10	-	-	PUNCT
admet-2455	57	11	well	well	NOUN
admet-2455	57	12	plates	plate	NOUN
admet-2455	57	13	and	and	CCONJ
admet-2455	57	14	incubated	incubate	VERB
admet-2455	57	15	overnight	overnight	ADV
admet-2455	57	16	to	to	PART
admet-2455	57	17	allow	allow	VERB
admet-2455	57	18	cell	cell	NOUN
admet-2455	57	19	attachment	attachment	NOUN
admet-2455	57	20	,	,	PUNCT
admet-2455	57	21	then	then	ADV
admet-2455	57	22	culture	culture	NOUN
admet-2455	57	23	medium	medium	NOUN
admet-2455	57	24	were	be	AUX
admet-2455	57	25	refreshed	refresh	VERB
admet-2455	57	26	with	with	ADP
admet-2455	57	27	medium	medium	ADJ
admet-2455	57	28	containing	contain	VERB
admet-2455	57	29	desired	desire	VERB
admet-2455	57	30	drug	drug	NOUN
admet-2455	57	31	and	and	CCONJ
admet-2455	57	32	treated	treat	VERB
admet-2455	57	33	for	for	ADP
admet-2455	57	34	additional	additional	ADJ
admet-2455	57	35	72	72	NUM
admet-2455	57	36	h.	h.	NOUN
admet-2455	57	37	subsequently	subsequently	ADV
admet-2455	57	38	,	,	PUNCT
admet-2455	57	39	the	the	DET
admet-2455	57	40	medium	medium	NOUN
admet-2455	57	41	was	be	AUX
admet-2455	57	42	discarded	discard	VERB
admet-2455	57	43	and	and	CCONJ
admet-2455	57	44	refreshed	refresh	VERB
admet-2455	57	45	with	with	ADP
admet-2455	57	46	100	100	NUM
admet-2455	57	47	μl	μl	DET
admet-2455	57	48	culture	culture	NOUN
admet-2455	57	49	media	medium	NOUN
admet-2455	57	50	containing	contain	VERB
admet-2455	57	51	0.5	0.5	NUM
admet-2455	57	52	mg	mg	PROPN
admet-2455	57	53	/	/	SYM
admet-2455	57	54	ml	ml	NOUN
admet-2455	57	55	mtt	mtt	NOUN
admet-2455	57	56	(	(	PUNCT
admet-2455	57	57	3-(4,5	3-(4,5	PROPN
admet-2455	57	58	-	-	PUNCT
admet-2455	57	59	dimethyl-2	dimethyl-2	PROPN
admet-2455	57	60	-	-	PUNCT
admet-2455	57	61	thiazolyl)-2,5	thiazolyl)-2,5	ADV
admet-2455	57	62	-	-	PUNCT
admet-2455	57	63	diphenyl-2	diphenyl-2	VERB
admet-2455	57	64	-	-	PUNCT
admet-2455	57	65	h	h	NOUN
admet-2455	57	66	-	-	PUNCT
admet-2455	57	67	tetrazoliumbromide	tetrazoliumbromide	NOUN
admet-2455	57	68	)	)	PUNCT
admet-2455	57	69	.	.	PUNCT
admet-2455	58	1	after	after	ADP
admet-2455	58	2	4	4	NUM
admet-2455	58	3	h	h	NOUN
admet-2455	58	4	incubation	incubation	NOUN
admet-2455	58	5	,	,	PUNCT
admet-2455	58	6	the	the	DET
admet-2455	58	7	supernatant	supernatant	NOUN
admet-2455	58	8	was	be	AUX
admet-2455	58	9	removed	remove	VERB
admet-2455	58	10	and	and	CCONJ
admet-2455	58	11	100	100	NUM
admet-2455	58	12	μl	μl	PRON
admet-2455	58	13	dmso	dmso	NOUN
admet-2455	58	14	were	be	AUX
admet-2455	58	15	added	add	VERB
admet-2455	58	16	to	to	PART
admet-2455	58	17	fully	fully	ADV
admet-2455	58	18	dissolve	dissolve	VERB
admet-2455	58	19	the	the	DET
admet-2455	58	20	formazan	formazan	ADJ
admet-2455	58	21	crystals	crystal	NOUN
admet-2455	58	22	.	.	PUNCT
admet-2455	59	1	at	at	ADP
admet-2455	59	2	last	last	ADJ
admet-2455	59	3	,	,	PUNCT
admet-2455	59	4	the	the	DET
admet-2455	59	5	o.d	o.d	PROPN
admet-2455	59	6	.	.	PROPN
admet-2455	59	7	values	value	NOUN
admet-2455	59	8	of	of	ADP
admet-2455	59	9	each	each	DET
admet-2455	59	10	well	well	ADV
admet-2455	59	11	were	be	AUX
admet-2455	59	12	read	read	VERB
admet-2455	59	13	at	at	ADP
admet-2455	59	14	570	570	NUM
admet-2455	59	15	nm	nm	NOUN
admet-2455	59	16	by	by	ADP
admet-2455	59	17	the	the	DET
admet-2455	59	18	spectra	spectra	ADJ
admet-2455	59	19	max	max	PROPN
admet-2455	59	20	m5	m5	PROPN
admet-2455	59	21	microplate	microplate	NOUN
admet-2455	59	22	reader	reader	NOUN
admet-2455	59	23	(	(	PUNCT
admet-2455	59	24	molecular	molecular	ADJ
admet-2455	59	25	devices	device	NOUN
admet-2455	59	26	,	,	PUNCT
admet-2455	59	27	usa	usa	PROPN
admet-2455	59	28	)	)	PUNCT
admet-2455	59	29	.	.	PUNCT
admet-2455	60	1	chou	chou	ADJ
admet-2455	60	2	-	-	PUNCT
admet-2455	60	3	talalay	talalay	NOUN
admet-2455	60	4	drug	drug	NOUN
admet-2455	60	5	synergy	synergy	NOUN
admet-2455	60	6	assessment	assessment	NOUN
admet-2455	60	7	drug	drug	NOUN
admet-2455	60	8	synergy	synergy	NOUN
admet-2455	60	9	was	be	AUX
admet-2455	60	10	assessed	assess	VERB
admet-2455	60	11	by	by	ADP
admet-2455	60	12	combination	combination	NOUN
admet-2455	60	13	index	index	NOUN
admet-2455	60	14	(	(	PUNCT
admet-2455	60	15	ci	ci	NOUN
admet-2455	60	16	)	)	PUNCT
admet-2455	60	17	,	,	PUNCT
admet-2455	60	18	equation	equation	NOUN
admet-2455	60	19	(	(	PUNCT
admet-2455	60	20	1	1	NUM
admet-2455	60	21	)	)	PUNCT
admet-2455	60	22	:	:	PUNCT
admet-2455	60	23	(	(	PUNCT
admet-2455	60	24	)	)	PUNCT
admet-2455	60	25	(	(	PUNCT
admet-2455	60	26	)	)	PUNCT
admet-2455	60	27	(	(	PUNCT
admet-2455	60	28	)	)	PUNCT
admet-2455	60	29	(	(	PUNCT
admet-2455	60	30	)	)	PUNCT
admet-2455	60	31	1	1	NUM
admet-2455	60	32	2	2	NUM
admet-2455	60	33	x	x	SYM
admet-2455	60	34	x1	x1	PROPN
admet-2455	60	35	2	2	NUM
admet-2455	60	36	ci	ci	NOUN
admet-2455	60	37	  	  	SPACE
admet-2455	60	38	d	d	PROPN
admet-2455	61	1	d	d	PROPN
admet-2455	61	2	d	d	X
admet-2455	61	3	d	d	PROPN
admet-2455	61	4	=	=	SYM
admet-2455	61	5	+	+	CCONJ
admet-2455	61	6	(	(	PUNCT
admet-2455	61	7	1	1	X
admet-2455	61	8	)	)	PUNCT
admet-2455	61	9	where	where	SCONJ
admet-2455	61	10	d1	d1	PROPN
admet-2455	61	11	and	and	CCONJ
admet-2455	61	12	d2	d2	PROPN
admet-2455	61	13	were	be	AUX
admet-2455	61	14	the	the	DET
admet-2455	61	15	drug	drug	NOUN
admet-2455	61	16	combination	combination	NOUN
admet-2455	61	17	doses	dose	NOUN
admet-2455	61	18	to	to	PART
admet-2455	61	19	achieve	achieve	VERB
admet-2455	61	20	a	a	DET
admet-2455	61	21	specific	specific	ADJ
admet-2455	61	22	effect	effect	NOUN
admet-2455	61	23	.	.	PUNCT
admet-2455	62	1	while	while	SCONJ
admet-2455	62	2	the	the	DET
admet-2455	62	3	individual	individual	ADJ
admet-2455	62	4	drug	drug	NOUN
admet-2455	62	5	dose	dose	NOUN
admet-2455	62	6	which	which	PRON
admet-2455	62	7	achieves	achieve	VERB
admet-2455	62	8	the	the	DET
admet-2455	62	9	equal	equal	ADJ
admet-2455	62	10	effect	effect	NOUN
admet-2455	62	11	were	be	AUX
admet-2455	62	12	represented	represent	VERB
admet-2455	62	13	as	as	ADP
admet-2455	62	14	(	(	PUNCT
admet-2455	62	15	dx)1	dx)1	PROPN
admet-2455	62	16	and	and	CCONJ
admet-2455	62	17	(	(	PUNCT
admet-2455	62	18	dx)2	dx)2	NOUN
admet-2455	62	19	.	.	PUNCT
admet-2455	63	1	the	the	DET
admet-2455	63	2	tcs	tcs	NOUN
admet-2455	63	3	and	and	CCONJ
admet-2455	63	4	benz	benz	PROPN
admet-2455	63	5	were	be	AUX
admet-2455	63	6	combined	combine	VERB
admet-2455	63	7	at	at	ADP
admet-2455	63	8	a	a	DET
admet-2455	63	9	non	non	ADJ
admet-2455	63	10	-	-	ADJ
admet-2455	63	11	fixed	fixed	ADJ
admet-2455	63	12	ratio	ratio	NOUN
admet-2455	63	13	.	.	PUNCT
admet-2455	64	1	ci	ci	PROPN
admet-2455	64	2	<	<	X
admet-2455	64	3	0.9	0.9	NUM
admet-2455	64	4	indicates	indicate	VERB
admet-2455	64	5	synergism	synergism	NOUN
admet-2455	64	6	,	,	PUNCT
admet-2455	64	7	0.9	0.9	NUM
admet-2455	64	8	<	<	X
admet-2455	64	9	ci	ci	NOUN
admet-2455	64	10	<	<	X
admet-2455	64	11	1.1	1.1	NUM
admet-2455	64	12	indicates	indicate	VERB
admet-2455	64	13	additivity	additivity	NOUN
admet-2455	64	14	,	,	PUNCT
admet-2455	64	15	and	and	CCONJ
admet-2455	64	16	ci	ci	X
admet-2455	64	17	>	>	X
admet-2455	64	18	1.1	1.1	NUM
admet-2455	64	19	indicates	indicate	VERB
admet-2455	64	20	antagonism	antagonism	NOUN
admet-2455	64	21	[	[	X
admet-2455	64	22	26	26	NUM
admet-2455	64	23	-	-	SYM
admet-2455	64	24	28	28	NUM
admet-2455	64	25	]	]	PUNCT
admet-2455	64	26	.	.	PUNCT
admet-2455	65	1	the	the	DET
admet-2455	65	2	calcusyn	calcusyn	PROPN
admet-2455	65	3	software	software	PROPN
admet-2455	65	4	(	(	PUNCT
admet-2455	65	5	biosoft	biosoft	ADJ
admet-2455	65	6	,	,	PUNCT
admet-2455	65	7	ferguson	ferguson	PROPN
admet-2455	65	8	,	,	PUNCT
admet-2455	65	9	mo	mo	PROPN
admet-2455	65	10	,	,	PUNCT
admet-2455	65	11	usa	usa	PROPN
admet-2455	65	12	)	)	PUNCT
admet-2455	65	13	was	be	AUX
admet-2455	65	14	used	use	VERB
admet-2455	65	15	to	to	PART
admet-2455	65	16	calculate	calculate	VERB
admet-2455	65	17	ci	ci	NOUN
admet-2455	65	18	values	value	NOUN
admet-2455	65	19	and	and	CCONJ
admet-2455	65	20	the	the	DET
admet-2455	65	21	fraction	fraction	NOUN
admet-2455	65	22	of	of	ADP
admet-2455	65	23	affected	affected	ADJ
admet-2455	65	24	(	(	PUNCT
admet-2455	65	25	fa	fa	NOUN
admet-2455	65	26	)	)	PUNCT
admet-2455	65	27	,	,	PUNCT
admet-2455	65	28	which	which	PRON
admet-2455	65	29	was	be	AUX
admet-2455	65	30	defined	define	VERB
admet-2455	65	31	by	by	ADP
admet-2455	65	32	equation	equation	NOUN
admet-2455	65	33	(	(	PUNCT
admet-2455	65	34	2	2	NUM
admet-2455	65	35	):	):	PUNCT
admet-2455	65	36	1	1	NUM
admet-2455	65	37	a	a	DET
admet-2455	65	38	x	x	PUNCT
admet-2455	65	39	a	a	DET
admet-2455	65	40	    	    	SPACE
admet-2455	65	41	1	1	NUM
admet-2455	65	42	m	m	NOUN
admet-2455	65	43	m	m	VERB
admet-2455	65	44	f	f	NOUN
admet-2455	65	45	d	d	PROPN
admet-2455	65	46	d	d	X
admet-2455	65	47	f	f	PROPN
admet-2455	65	48			PROPN
admet-2455	65	49			NOUN
admet-2455	65	50	=	=	SYM
admet-2455	65	51			NOUN
admet-2455	65	52			PROPN
admet-2455	65	53	−	−	PROPN
admet-2455	65	54			PROPN
admet-2455	65	55	(	(	PUNCT
admet-2455	65	56	2	2	NUM
admet-2455	65	57	)	)	PUNCT
admet-2455	65	58	dm	dm	NOUN
admet-2455	65	59	,	,	PUNCT
admet-2455	65	60	represents	represent	VERB
admet-2455	65	61	the	the	DET
admet-2455	65	62	concentration	concentration	NOUN
admet-2455	65	63	(	(	PUNCT
admet-2455	65	64	e.g.	e.g.	ADV
admet-2455	65	65	ic50	ic50	PROPN
admet-2455	65	66	)	)	PUNCT
admet-2455	65	67	at	at	ADP
admet-2455	65	68	which	which	PRON
admet-2455	65	69	50	50	NUM
admet-2455	65	70	%	%	NOUN
admet-2455	65	71	inhibition	inhibition	NOUN
admet-2455	65	72	of	of	ADP
admet-2455	65	73	cancer	cancer	NOUN
admet-2455	65	74	cells	cell	NOUN
admet-2455	65	75	occurs	occur	VERB
admet-2455	65	76	.	.	PUNCT
admet-2455	66	1	the	the	DET
admet-2455	66	2	slope	slope	NOUN
admet-2455	66	3	coefficient	coefficient	NOUN
admet-2455	66	4	(	(	PUNCT
admet-2455	66	5	m	m	NOUN
admet-2455	66	6	)	)	PUNCT
admet-2455	66	7	determines	determine	VERB
admet-2455	66	8	the	the	DET
admet-2455	66	9	shape	shape	NOUN
admet-2455	66	10	of	of	ADP
admet-2455	66	11	the	the	DET
admet-2455	66	12	dose	dose	NOUN
admet-2455	66	13	-	-	PUNCT
admet-2455	66	14	effect	effect	NOUN
admet-2455	66	15	curve	curve	NOUN
admet-2455	66	16	in	in	ADP
admet-2455	66	17	the	the	DET
admet-2455	66	18	dose	dose	NOUN
admet-2455	66	19	-	-	PUNCT
admet-2455	66	20	effect	effect	NOUN
admet-2455	66	21	relationship	relationship	NOUN
admet-2455	66	22	.	.	PUNCT
admet-2455	67	1	value	value	NOUN
admet-2455	67	2	of	of	ADP
admet-2455	67	3	m	m	NOUN
admet-2455	67	4	equal	equal	ADJ
admet-2455	67	5	1	1	NUM
admet-2455	67	6	indicates	indicate	VERB
admet-2455	67	7	a	a	DET
admet-2455	67	8	hyperbolic	hyperbolic	ADJ
admet-2455	67	9	dose	dose	NOUN
admet-2455	67	10	-	-	PUNCT
admet-2455	67	11	effect	effect	NOUN
admet-2455	67	12	curve	curve	NOUN
admet-2455	67	13	,	,	PUNCT
admet-2455	67	14	while	while	SCONJ
admet-2455	67	15	values	value	NOUN
admet-2455	67	16	greater	great	ADJ
admet-2455	67	17	than	than	ADP
admet-2455	67	18	1	1	NUM
admet-2455	67	19	and	and	CCONJ
admet-2455	67	20	less	less	ADJ
admet-2455	67	21	than	than	ADP
admet-2455	67	22	1	1	NUM
admet-2455	67	23	represent	represent	VERB
admet-2455	67	24	sigmoidal	sigmoidal	NOUN
admet-2455	67	25	and	and	CCONJ
admet-2455	67	26	flat	flat	ADJ
admet-2455	67	27	sigmoidal	sigmoidal	NOUN
admet-2455	67	28	curves	curve	NOUN
admet-2455	67	29	,	,	PUNCT
admet-2455	67	30	respectively	respectively	ADV
admet-2455	67	31	.	.	PUNCT
admet-2455	68	1	the	the	DET
admet-2455	68	2	ci	ci	PROPN
admet-2455	68	3	values	value	NOUN
admet-2455	68	4	were	be	AUX
admet-2455	68	5	plotted	plot	VERB
admet-2455	68	6	against	against	ADP
admet-2455	68	7	the	the	DET
admet-2455	68	8	fraction	fraction	NOUN
admet-2455	68	9	affected	affect	VERB
admet-2455	68	10	(	(	PUNCT
admet-2455	68	11	fa	fa	NOUN
admet-2455	68	12	)	)	PUNCT
admet-2455	68	13	,	,	PUNCT
admet-2455	68	14	and	and	CCONJ
admet-2455	68	15	the	the	DET
admet-2455	68	16	data	datum	NOUN
admet-2455	68	17	were	be	AUX
admet-2455	68	18	also	also	ADV
admet-2455	68	19	evaluated	evaluate	VERB
admet-2455	68	20	using	use	VERB
admet-2455	68	21	the	the	DET
admet-2455	68	22	combination	combination	NOUN
admet-2455	68	23	index	index	NOUN
admet-2455	68	24	-	-	PUNCT
admet-2455	68	25	isobologram	isobologram	NOUN
admet-2455	68	26	equation	equation	NOUN
admet-2455	68	27	.	.	PUNCT
admet-2455	69	1	only	only	ADV
admet-2455	69	2	ci	ci	PROPN
admet-2455	69	3	values	value	NOUN
admet-2455	69	4	obtained	obtain	VERB
admet-2455	69	5	at	at	ADP
admet-2455	69	6	fa	fa	PROPN
admet-2455	69	7	values	value	NOUN
admet-2455	69	8	>	>	X
admet-2455	69	9	0.5	0.5	NUM
admet-2455	69	10	can	can	AUX
admet-2455	69	11	be	be	AUX
admet-2455	69	12	considered	consider	VERB
admet-2455	69	13	as	as	ADP
admet-2455	69	14	relevant	relevant	ADJ
admet-2455	69	15	[	[	X
admet-2455	69	16	28	28	NUM
admet-2455	69	17	]	]	PUNCT
admet-2455	69	18	.	.	PUNCT
admet-2455	70	1	seahorse	seahorse	PROPN
admet-2455	70	2	xfe96	xfe96	PROPN
admet-2455	70	3	analysis	analysis	NOUN
admet-2455	70	4	the	the	DET
admet-2455	70	5	glycolytic	glycolytic	ADJ
admet-2455	70	6	function	function	NOUN
admet-2455	70	7	parameter	parameter	NOUN
admet-2455	70	8	extracellular	extracellular	ADJ
admet-2455	70	9	acidification	acidification	NOUN
admet-2455	70	10	rate	rate	NOUN
admet-2455	70	11	(	(	PUNCT
admet-2455	70	12	ecar	ecar	NOUN
admet-2455	70	13	)	)	PUNCT
admet-2455	70	14	was	be	AUX
admet-2455	70	15	measured	measure	VERB
admet-2455	70	16	using	use	VERB
admet-2455	70	17	a	a	DET
admet-2455	70	18	seahorse	seahorse	NOUN
admet-2455	70	19	xfe96	xfe96	NOUN
admet-2455	70	20	analyzer	analyzer	NOUN
admet-2455	70	21	(	(	PUNCT
admet-2455	70	22	agilent	agilent	PROPN
admet-2455	70	23	technologies	technologies	PROPN
admet-2455	70	24	,	,	PUNCT
admet-2455	70	25	usa	usa	PROPN
admet-2455	70	26	)	)	PUNCT
admet-2455	70	27	.	.	PUNCT
admet-2455	71	1	approximately	approximately	ADV
admet-2455	71	2	25,000	25,000	NUM
admet-2455	71	3	cells	cell	NOUN
admet-2455	71	4	per	per	ADP
admet-2455	71	5	well	well	ADV
admet-2455	71	6	were	be	AUX
admet-2455	71	7	seeded	seed	VERB
admet-2455	71	8	in	in	ADP
admet-2455	71	9	xf96	xf96	PROPN
admet-2455	71	10	-	-	PUNCT
admet-2455	71	11	well	well	NOUN
admet-2455	71	12	plates	plate	NOUN
admet-2455	71	13	,	,	PUNCT
admet-2455	71	14	cells	cell	NOUN
admet-2455	71	15	were	be	AUX
admet-2455	71	16	treated	treat	VERB
admet-2455	71	17	with	with	ADP
admet-2455	71	18	tcs	tcs	PROPN
admet-2455	71	19	and	and	CCONJ
admet-2455	71	20	benz	benz	PROPN
admet-2455	71	21	alone	alone	ADV
admet-2455	71	22	or	or	CCONJ
admet-2455	71	23	in	in	ADP
admet-2455	71	24	combination	combination	NOUN
admet-2455	71	25	for	for	ADP
admet-2455	71	26	18	18	NUM
admet-2455	71	27	h.	h.	NOUN
admet-2455	71	28	the	the	DET
admet-2455	71	29	glycolysis	glycolysis	NOUN
admet-2455	71	30	stress	stress	NOUN
admet-2455	71	31	test	test	NOUN
admet-2455	71	32	was	be	AUX
admet-2455	71	33	utilized	utilize	VERB
admet-2455	71	34	to	to	PART
admet-2455	71	35	analyse	analyse	VERB
admet-2455	71	36	glycolysis	glycolysis	NOUN
admet-2455	71	37	activity	activity	NOUN
admet-2455	71	38	.	.	PUNCT
admet-2455	72	1	briefly	briefly	ADV
admet-2455	72	2	,	,	PUNCT
admet-2455	72	3	the	the	DET
admet-2455	72	4	culture	culture	NOUN
admet-2455	72	5	medium	medium	NOUN
admet-2455	72	6	was	be	AUX
admet-2455	72	7	replaced	replace	VERB
admet-2455	72	8	with	with	ADP
admet-2455	72	9	xf	xf	PROPN
admet-2455	72	10	assay	assay	PROPN
admet-2455	72	11	medium	medium	NOUN
admet-2455	72	12	containing	contain	VERB
admet-2455	72	13	2	2	NUM
admet-2455	72	14	mm	mm	NOUN
admet-2455	72	15	glutamine	glutamine	NOUN
admet-2455	72	16	and	and	CCONJ
admet-2455	72	17	no	no	DET
admet-2455	72	18	glucose	glucose	NOUN
admet-2455	72	19	,	,	PUNCT
admet-2455	72	20	and	and	CCONJ
admet-2455	72	21	the	the	DET
admet-2455	72	22	cells	cell	NOUN
admet-2455	72	23	were	be	AUX
admet-2455	72	24	incubated	incubate	VERB
admet-2455	72	25	at	at	ADP
admet-2455	72	26	37	37	NUM
admet-2455	72	27	°	°	SYM
admet-2455	72	28	c	c	NOUN
admet-2455	72	29	in	in	ADP
admet-2455	72	30	a	a	DET
admet-2455	72	31	co2	co2	NOUN
admet-2455	72	32	-	-	PUNCT
admet-2455	72	33	free	free	ADJ
admet-2455	72	34	incubator	incubator	NOUN
admet-2455	72	35	for	for	ADP
admet-2455	72	36	1	1	NUM
admet-2455	72	37	h.	h.	NOUN
admet-2455	72	38	the	the	DET
admet-2455	72	39	glycolysis	glycolysis	NOUN
admet-2455	72	40	stress	stress	NOUN
admet-2455	72	41	test	test	NOUN
admet-2455	72	42	kit	kit	NOUN
admet-2455	72	43	(	(	PUNCT
admet-2455	72	44	agilent	agilent	PROPN
admet-2455	72	45	technologies	technologies	PROPN
admet-2455	72	46	,	,	PUNCT
admet-2455	72	47	usa	usa	PROPN
admet-2455	72	48	)	)	PUNCT
admet-2455	72	49	involved	involve	VERB
admet-2455	72	50	sequentially	sequentially	ADV
admet-2455	72	51	adding	add	VERB
admet-2455	72	52	glucose	glucose	NOUN
admet-2455	72	53	(	(	PUNCT
admet-2455	72	54	10	10	NUM
admet-2455	72	55	mm	mm	NOUN
admet-2455	72	56	)	)	PUNCT
admet-2455	72	57	,	,	PUNCT
admet-2455	72	58	oligomycin	oligomycin	INTJ
admet-2455	72	59	(	(	PUNCT
admet-2455	72	60	1	1	NUM
admet-2455	72	61	μm	μm	NUM
admet-2455	72	62	)	)	PUNCT
admet-2455	72	63	,	,	PUNCT
admet-2455	72	64	and	and	CCONJ
admet-2455	72	65	2	2	NUM
admet-2455	72	66	-	-	PUNCT
admet-2455	72	67	deoxyglucose	deoxyglucose	NOUN
admet-2455	72	68	(	(	PUNCT
admet-2455	72	69	2	2	NUM
admet-2455	72	70	-	-	PUNCT
admet-2455	72	71	dg	dg	NOUN
admet-2455	72	72	,	,	PUNCT
admet-2455	72	73	50	50	NUM
admet-2455	72	74	mm	mm	NOUN
admet-2455	72	75	)	)	PUNCT
admet-2455	72	76	.	.	PUNCT
admet-2455	73	1	after	after	ADP
admet-2455	73	2	each	each	DET
admet-2455	73	3	injection	injection	NOUN
admet-2455	73	4	,	,	PUNCT
admet-2455	73	5	the	the	DET
admet-2455	73	6	ecar	ecar	NOUN
admet-2455	73	7	was	be	AUX
admet-2455	73	8	measured	measure	VERB
admet-2455	73	9	,	,	PUNCT
admet-2455	73	10	and	and	CCONJ
admet-2455	73	11	the	the	DET
admet-2455	73	12	data	datum	NOUN
admet-2455	73	13	were	be	AUX
admet-2455	73	14	normalized	normalize	VERB
admet-2455	73	15	to	to	ADP
admet-2455	73	16	the	the	DET
admet-2455	73	17	cell	cell	NOUN
admet-2455	73	18	number	number	NOUN
admet-2455	73	19	in	in	ADP
admet-2455	73	20	each	each	DET
admet-2455	73	21	well	well	NOUN
admet-2455	73	22	.	.	PUNCT
admet-2455	74	1	data	datum	NOUN
admet-2455	74	2	analysis	analysis	NOUN
admet-2455	74	3	was	be	AUX
admet-2455	74	4	performed	perform	VERB
admet-2455	74	5	in	in	ADP
admet-2455	74	6	wave	wave	NOUN
admet-2455	74	7	software	software	NOUN
admet-2455	74	8	(	(	PUNCT
admet-2455	74	9	agilent	agilent	PROPN
admet-2455	74	10	technologies	technologies	PROPN
admet-2455	74	11	,	,	PUNCT
admet-2455	74	12	usa	usa	PROPN
admet-2455	74	13	)	)	PUNCT
admet-2455	74	14	.	.	PUNCT
admet-2455	75	1	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	X
admet-2455	75	2	y.	y.	NOUN
admet-2455	75	3	zhou	zhou	PROPN
admet-2455	75	4	et	et	PROPN
admet-2455	75	5	al	al	PROPN
admet-2455	75	6	.	.	PROPN
admet-2455	75	7	admet	admet	PROPN
admet-2455	75	8	&	&	CCONJ
admet-2455	75	9	dmpk	dmpk	PROPN
admet-2455	75	10	12(6	12(6	NUM
admet-2455	75	11	)	)	PUNCT
admet-2455	75	12	(	(	PUNCT
admet-2455	75	13	2024	2024	NUM
admet-2455	75	14	)	)	PUNCT
admet-2455	75	15	821	821	NUM
admet-2455	75	16	-	-	SYM
admet-2455	75	17	841	841	NUM
admet-2455	75	18	824	824	NUM
admet-2455	75	19	measurement	measurement	NOUN
admet-2455	75	20	of	of	ADP
admet-2455	75	21	lactate	lactate	NOUN
admet-2455	75	22	secretion	secretion	NOUN
admet-2455	75	23	to	to	PART
admet-2455	75	24	measure	measure	VERB
admet-2455	75	25	the	the	DET
admet-2455	75	26	extracellular	extracellular	ADJ
admet-2455	75	27	lactate	lactate	NOUN
admet-2455	75	28	secretion	secretion	NOUN
admet-2455	75	29	,	,	PUNCT
admet-2455	75	30	cells	cell	NOUN
admet-2455	75	31	were	be	AUX
admet-2455	75	32	seeded	seed	VERB
admet-2455	75	33	in	in	ADP
admet-2455	75	34	6	6	NUM
admet-2455	75	35	-	-	PUNCT
admet-2455	75	36	well	well	NOUN
admet-2455	75	37	plates	plate	NOUN
admet-2455	75	38	and	and	CCONJ
admet-2455	75	39	treated	treat	VERB
admet-2455	75	40	with	with	ADP
admet-2455	75	41	either	either	CCONJ
admet-2455	75	42	tcs	tcs	PROPN
admet-2455	75	43	or	or	CCONJ
admet-2455	75	44	benz	benz	PROPN
admet-2455	75	45	alone	alone	ADV
admet-2455	75	46	,	,	PUNCT
admet-2455	75	47	or	or	CCONJ
admet-2455	75	48	in	in	ADP
admet-2455	75	49	combination	combination	NOUN
admet-2455	75	50	for	for	ADP
admet-2455	75	51	24	24	NUM
admet-2455	75	52	h.	h.	NOUN
admet-2455	75	53	the	the	DET
admet-2455	75	54	supernatants	supernatant	NOUN
admet-2455	75	55	of	of	ADP
admet-2455	75	56	each	each	DET
admet-2455	75	57	sample	sample	NOUN
admet-2455	75	58	were	be	AUX
admet-2455	75	59	collected	collect	VERB
admet-2455	75	60	and	and	CCONJ
admet-2455	75	61	then	then	ADV
admet-2455	75	62	centrifuged	centrifuge	VERB
admet-2455	75	63	at	at	ADP
admet-2455	75	64	8000	8000	NUM
admet-2455	75	65	rpm	rpm	NOUN
admet-2455	75	66	for	for	SCONJ
admet-2455	75	67	5	5	NUM
admet-2455	75	68	min	min	NOUN
admet-2455	75	69	to	to	PART
admet-2455	75	70	remove	remove	VERB
admet-2455	75	71	any	any	DET
admet-2455	75	72	cellular	cellular	ADJ
admet-2455	75	73	debris	debris	NOUN
admet-2455	75	74	.	.	PUNCT
admet-2455	76	1	the	the	DET
admet-2455	76	2	lactate	lactate	NOUN
admet-2455	76	3	concentration	concentration	NOUN
admet-2455	76	4	in	in	ADP
admet-2455	76	5	the	the	DET
admet-2455	76	6	supernatant	supernatant	NOUN
admet-2455	76	7	was	be	AUX
admet-2455	76	8	measured	measure	VERB
admet-2455	76	9	using	use	VERB
admet-2455	76	10	the	the	DET
admet-2455	76	11	nova	nova	PROPN
admet-2455	76	12	bioprofile	bioprofile	NOUN
admet-2455	76	13	flex	flex	ADJ
admet-2455	76	14	analyser	analyser	NOUN
admet-2455	76	15	(	(	PUNCT
admet-2455	76	16	nova	nova	PROPN
admet-2455	76	17	biomedical	biomedical	PROPN
admet-2455	76	18	,	,	PUNCT
admet-2455	76	19	usa	usa	PROPN
admet-2455	76	20	)	)	PUNCT
admet-2455	76	21	,	,	PUNCT
admet-2455	76	22	which	which	PRON
admet-2455	76	23	utilized	utilize	VERB
admet-2455	76	24	a	a	DET
admet-2455	76	25	combination	combination	NOUN
admet-2455	76	26	of	of	ADP
admet-2455	76	27	enzymatic	enzymatic	ADJ
admet-2455	76	28	and	and	CCONJ
admet-2455	76	29	optical	optical	ADJ
admet-2455	76	30	methods	method	NOUN
admet-2455	76	31	to	to	PART
admet-2455	76	32	detect	detect	VERB
admet-2455	76	33	and	and	CCONJ
admet-2455	76	34	quantify	quantify	VERB
admet-2455	76	35	lactate	lactate	NOUN
admet-2455	76	36	levels	level	NOUN
admet-2455	76	37	.	.	PUNCT
admet-2455	77	1	colony	colony	NOUN
admet-2455	77	2	formation	formation	NOUN
admet-2455	77	3	assay	assay	NOUN
admet-2455	77	4	cells	cell	NOUN
admet-2455	77	5	were	be	AUX
admet-2455	77	6	seeded	seed	VERB
admet-2455	77	7	into	into	ADP
admet-2455	77	8	6	6	NUM
admet-2455	77	9	-	-	PUNCT
admet-2455	77	10	well	well	NOUN
admet-2455	77	11	plates	plate	NOUN
admet-2455	77	12	at	at	ADP
admet-2455	77	13	a	a	DET
admet-2455	77	14	respective	respective	ADJ
admet-2455	77	15	optimized	optimize	VERB
admet-2455	77	16	density	density	NOUN
admet-2455	77	17	from	from	ADP
admet-2455	77	18	100	100	NUM
admet-2455	77	19	to	to	PART
admet-2455	77	20	300	300	NUM
admet-2455	77	21	cells	cell	NOUN
admet-2455	77	22	per	per	ADP
admet-2455	77	23	well	well	ADV
admet-2455	77	24	.	.	PUNCT
admet-2455	78	1	after	after	ADP
admet-2455	78	2	24	24	NUM
admet-2455	78	3	h	h	NOUN
admet-2455	78	4	incubation	incubation	NOUN
admet-2455	78	5	,	,	PUNCT
admet-2455	78	6	the	the	DET
admet-2455	78	7	culture	culture	NOUN
admet-2455	78	8	medium	medium	NOUN
admet-2455	78	9	was	be	AUX
admet-2455	78	10	refreshed	refresh	VERB
admet-2455	78	11	with	with	ADP
admet-2455	78	12	medium	medium	ADJ
admet-2455	78	13	containing	contain	VERB
admet-2455	78	14	designed	design	VERB
admet-2455	78	15	individual	individual	ADJ
admet-2455	78	16	or	or	CCONJ
admet-2455	78	17	combination	combination	NOUN
admet-2455	78	18	of	of	ADP
admet-2455	78	19	compounds	compound	NOUN
admet-2455	78	20	treatment	treatment	NOUN
admet-2455	78	21	.	.	PUNCT
admet-2455	79	1	after	after	ADP
admet-2455	79	2	72	72	NUM
admet-2455	79	3	h	h	NOUN
admet-2455	79	4	treatment	treatment	NOUN
admet-2455	79	5	,	,	PUNCT
admet-2455	79	6	the	the	DET
admet-2455	79	7	medium	medium	NOUN
admet-2455	79	8	was	be	AUX
admet-2455	79	9	replaced	replace	VERB
admet-2455	79	10	with	with	ADP
admet-2455	79	11	compound	compound	NOUN
admet-2455	79	12	-	-	PUNCT
admet-2455	79	13	free	free	ADJ
admet-2455	79	14	culture	culture	NOUN
admet-2455	79	15	medium	medium	NOUN
admet-2455	79	16	every	every	DET
admet-2455	79	17	3	3	NUM
admet-2455	79	18	to	to	PART
admet-2455	79	19	4	4	NUM
admet-2455	79	20	days	day	NOUN
admet-2455	79	21	.	.	PUNCT
admet-2455	80	1	when	when	SCONJ
admet-2455	80	2	the	the	DET
admet-2455	80	3	control	control	NOUN
admet-2455	80	4	wells	well	NOUN
admet-2455	80	5	which	which	PRON
admet-2455	80	6	with	with	ADP
admet-2455	80	7	no	no	DET
admet-2455	80	8	treatment	treatment	NOUN
admet-2455	80	9	were	be	AUX
admet-2455	80	10	filled	fill	VERB
admet-2455	80	11	with	with	ADP
admet-2455	80	12	colonies	colony	NOUN
admet-2455	80	13	which	which	PRON
admet-2455	80	14	would	would	AUX
admet-2455	80	15	take	take	VERB
admet-2455	80	16	about	about	ADV
admet-2455	80	17	2	2	NUM
admet-2455	80	18	weeks	week	NOUN
admet-2455	80	19	,	,	PUNCT
admet-2455	80	20	all	all	DET
admet-2455	80	21	wells	well	NOUN
admet-2455	80	22	were	be	AUX
admet-2455	80	23	added	add	VERB
admet-2455	80	24	with	with	ADP
admet-2455	80	25	95	95	NUM
admet-2455	80	26	%	%	NOUN
admet-2455	80	27	ethanol	ethanol	NOUN
admet-2455	80	28	for	for	ADP
admet-2455	80	29	15	15	NUM
admet-2455	80	30	min	min	NOUN
admet-2455	80	31	to	to	PART
admet-2455	80	32	fix	fix	VERB
admet-2455	80	33	the	the	DET
admet-2455	80	34	colonies	colony	NOUN
admet-2455	80	35	,	,	PUNCT
admet-2455	80	36	and	and	CCONJ
admet-2455	80	37	then	then	ADV
admet-2455	80	38	stained	stain	VERB
admet-2455	80	39	with	with	ADP
admet-2455	80	40	0.1	0.1	NUM
admet-2455	80	41	%	%	NOUN
admet-2455	80	42	crystal	crystal	NOUN
admet-2455	80	43	violet	violet	NOUN
admet-2455	80	44	(	(	PUNCT
admet-2455	80	45	sigma	sigma	PROPN
admet-2455	80	46	aldrich	aldrich	PROPN
admet-2455	80	47	,	,	PUNCT
admet-2455	80	48	usa	usa	PROPN
admet-2455	80	49	)	)	PUNCT
admet-2455	80	50	.	.	PUNCT
admet-2455	81	1	the	the	DET
admet-2455	81	2	image	image	NOUN
admet-2455	81	3	j	j	PROPN
admet-2455	81	4	software	software	NOUN
admet-2455	81	5	package	package	NOUN
admet-2455	81	6	was	be	AUX
admet-2455	81	7	used	use	VERB
admet-2455	81	8	to	to	PART
admet-2455	81	9	count	count	VERB
admet-2455	81	10	colonies	colony	NOUN
admet-2455	81	11	in	in	ADP
admet-2455	81	12	each	each	DET
admet-2455	81	13	well	well	NOUN
admet-2455	81	14	.	.	PUNCT
admet-2455	82	1	cell	cell	NOUN
admet-2455	82	2	cycle	cycle	NOUN
admet-2455	82	3	analysis	analysis	NOUN
admet-2455	82	4	cells	cell	NOUN
admet-2455	82	5	were	be	AUX
admet-2455	82	6	seeded	seed	VERB
admet-2455	82	7	in	in	ADP
admet-2455	82	8	6	6	NUM
admet-2455	82	9	-	-	PUNCT
admet-2455	82	10	well	well	NOUN
admet-2455	82	11	plates	plate	NOUN
admet-2455	82	12	,	,	PUNCT
admet-2455	82	13	after	after	ADP
admet-2455	82	14	24	24	NUM
admet-2455	82	15	h	h	NOUN
admet-2455	82	16	attachment	attachment	NOUN
admet-2455	82	17	,	,	PUNCT
admet-2455	82	18	cells	cell	NOUN
admet-2455	82	19	were	be	AUX
admet-2455	82	20	exposed	expose	VERB
admet-2455	82	21	to	to	ADP
admet-2455	82	22	drug	drug	NOUN
admet-2455	82	23	treatment	treatment	NOUN
admet-2455	82	24	for	for	ADP
admet-2455	82	25	24	24	NUM
admet-2455	82	26	h.	h.	NOUN
admet-2455	82	27	then	then	ADV
admet-2455	82	28	cells	cell	NOUN
admet-2455	82	29	were	be	AUX
admet-2455	82	30	harvested	harvest	VERB
admet-2455	82	31	,	,	PUNCT
admet-2455	82	32	washed	wash	VERB
admet-2455	82	33	and	and	CCONJ
admet-2455	82	34	fixed	fix	VERB
admet-2455	82	35	with	with	ADP
admet-2455	82	36	70	70	NUM
admet-2455	82	37	%	%	NOUN
admet-2455	82	38	ethanol	ethanol	NOUN
admet-2455	82	39	for	for	ADP
admet-2455	82	40	at	at	ADP
admet-2455	82	41	4	4	NUM
admet-2455	82	42	°	°	NOUN
admet-2455	82	43	c	c	NOUN
admet-2455	82	44	refrigerator	refrigerator	NOUN
admet-2455	82	45	for	for	ADP
admet-2455	82	46	24	24	NUM
admet-2455	82	47	h.	h.	NOUN
admet-2455	82	48	then	then	ADV
admet-2455	82	49	cell	cell	NOUN
admet-2455	82	50	samples	sample	NOUN
admet-2455	82	51	were	be	AUX
admet-2455	82	52	washed	wash	VERB
admet-2455	82	53	with	with	ADP
admet-2455	82	54	1x	1x	PROPN
admet-2455	82	55	pbs	pbs	PROPN
admet-2455	82	56	and	and	CCONJ
admet-2455	82	57	incubated	incubate	VERB
admet-2455	82	58	with	with	ADP
admet-2455	82	59	50	50	NUM
admet-2455	82	60	l	l	NOUN
admet-2455	82	61	of	of	ADP
admet-2455	82	62	100	100	NUM
admet-2455	82	63	g	g	NOUN
admet-2455	82	64	/	/	SYM
admet-2455	82	65	ml	ml	NOUN
admet-2455	82	66	rnaase	rnaase	NOUN
admet-2455	82	67	for	for	ADP
admet-2455	82	68	30	30	NUM
admet-2455	82	69	min	min	NOUN
admet-2455	82	70	,	,	PUNCT
admet-2455	82	71	followed	follow	VERB
admet-2455	82	72	by	by	ADP
admet-2455	82	73	adding	add	VERB
admet-2455	82	74	200	200	NUM
admet-2455	82	75	l	l	NOUN
admet-2455	82	76	cold	cold	ADJ
admet-2455	82	77	propidium	propidium	NOUN
admet-2455	82	78	iodide	iodide	NOUN
admet-2455	82	79	(	(	PUNCT
admet-2455	82	80	sigma	sigma	PROPN
admet-2455	82	81	aldrich	aldrich	PROPN
admet-2455	82	82	,	,	PUNCT
admet-2455	82	83	usa	usa	PROPN
admet-2455	82	84	)	)	PUNCT
admet-2455	82	85	(	(	PUNCT
admet-2455	82	86	50	50	NUM
admet-2455	82	87	g	g	NOUN
admet-2455	82	88	/	/	SYM
admet-2455	82	89	ml	ml	NOUN
admet-2455	82	90	)	)	PUNCT
admet-2455	82	91	and	and	CCONJ
admet-2455	82	92	incubated	incubate	VERB
admet-2455	82	93	on	on	ADP
admet-2455	82	94	ice	ice	NOUN
admet-2455	82	95	for	for	ADP
admet-2455	82	96	30	30	NUM
admet-2455	82	97	min	min	NOUN
admet-2455	82	98	.	.	PROPN
admet-2455	82	99	finally	finally	ADV
admet-2455	82	100	,	,	PUNCT
admet-2455	82	101	the	the	DET
admet-2455	82	102	cell	cell	NOUN
admet-2455	82	103	cycle	cycle	NOUN
admet-2455	82	104	distribution	distribution	NOUN
admet-2455	82	105	was	be	AUX
admet-2455	82	106	analysed	analyse	VERB
admet-2455	82	107	using	use	VERB
admet-2455	82	108	a	a	DET
admet-2455	82	109	cyto	cyto	ADJ
admet-2455	82	110	-	-	PUNCT
admet-2455	82	111	flex	flex	ADJ
admet-2455	82	112	flow	flow	NOUN
admet-2455	82	113	cytometer	cytometer	NOUN
admet-2455	82	114	(	(	PUNCT
admet-2455	82	115	beckman	beckman	PROPN
admet-2455	82	116	coulter	coulter	PROPN
admet-2455	82	117	,	,	PUNCT
admet-2455	82	118	indianapolis	indianapolis	PROPN
admet-2455	82	119	,	,	PUNCT
admet-2455	82	120	in	in	ADP
admet-2455	82	121	,	,	PUNCT
admet-2455	82	122	usa	usa	PROPN
admet-2455	82	123	)	)	PUNCT
admet-2455	82	124	.	.	PUNCT
admet-2455	83	1	measurement	measurement	NOUN
admet-2455	83	2	of	of	ADP
admet-2455	83	3	reactive	reactive	ADJ
admet-2455	83	4	oxygen	oxygen	NOUN
admet-2455	83	5	species	specie	NOUN
admet-2455	83	6	intracellular	intracellular	ADJ
admet-2455	83	7	levels	level	NOUN
admet-2455	83	8	of	of	ADP
admet-2455	83	9	reactive	reactive	ADJ
admet-2455	83	10	oxygen	oxygen	NOUN
admet-2455	83	11	species	specie	NOUN
admet-2455	83	12	(	(	PUNCT
admet-2455	83	13	ros	ros	PROPN
admet-2455	83	14	)	)	PUNCT
admet-2455	83	15	were	be	AUX
admet-2455	83	16	assessed	assess	VERB
admet-2455	83	17	using	use	VERB
admet-2455	83	18	the	the	DET
admet-2455	83	19	reactive	reactive	ADJ
admet-2455	83	20	oxygen	oxygen	NOUN
admet-2455	83	21	species	specie	NOUN
admet-2455	83	22	assay	assay	NOUN
admet-2455	83	23	kit	kit	NOUN
admet-2455	83	24	(	(	PUNCT
admet-2455	83	25	beyotime	beyotime	NOUN
admet-2455	83	26	,	,	PUNCT
admet-2455	83	27	china	china	PROPN
admet-2455	83	28	)	)	PUNCT
admet-2455	83	29	.	.	PUNCT
admet-2455	84	1	the	the	DET
admet-2455	84	2	assay	assay	ADV
admet-2455	84	3	utilized	utilize	VERB
admet-2455	84	4	2',7'-dichlorofluorescein	2',7'-dichlorofluorescein	NUM
admet-2455	84	5	diacetate	diacetate	ADJ
admet-2455	84	6	(	(	PUNCT
admet-2455	84	7	dcfh	dcfh	NOUN
admet-2455	84	8	-	-	PUNCT
admet-2455	84	9	da	da	NOUN
admet-2455	84	10	)	)	PUNCT
admet-2455	84	11	as	as	ADP
admet-2455	84	12	a	a	DET
admet-2455	84	13	fluorescent	fluorescent	ADJ
admet-2455	84	14	probe	probe	NOUN
admet-2455	84	15	.	.	PUNCT
admet-2455	85	1	briefly	briefly	NOUN
admet-2455	85	2	,	,	PUNCT
admet-2455	85	3	cells	cell	NOUN
admet-2455	85	4	were	be	AUX
admet-2455	85	5	seeded	seed	VERB
admet-2455	85	6	at	at	ADP
admet-2455	85	7	a	a	DET
admet-2455	85	8	density	density	NOUN
admet-2455	85	9	of	of	ADP
admet-2455	85	10	3×104	3×104	NUM
admet-2455	85	11	cells	cell	NOUN
admet-2455	85	12	per	per	ADP
admet-2455	85	13	well	well	ADV
admet-2455	85	14	in	in	ADP
admet-2455	85	15	96	96	NUM
admet-2455	85	16	-	-	PUNCT
admet-2455	85	17	well	well	NOUN
admet-2455	85	18	plates	plate	NOUN
admet-2455	85	19	and	and	CCONJ
admet-2455	85	20	incubated	incubate	VERB
admet-2455	85	21	overnight	overnight	ADV
admet-2455	85	22	at	at	ADP
admet-2455	85	23	37	37	NUM
admet-2455	85	24	°	°	NOUN
admet-2455	85	25	c	c	NOUN
admet-2455	85	26	.	.	PUNCT
admet-2455	86	1	subsequently	subsequently	ADV
admet-2455	86	2	,	,	PUNCT
admet-2455	86	3	the	the	DET
admet-2455	86	4	cells	cell	NOUN
admet-2455	86	5	were	be	AUX
admet-2455	86	6	treated	treat	VERB
admet-2455	86	7	with	with	ADP
admet-2455	86	8	10	10	NUM
admet-2455	86	9	μm	μm	NUM
admet-2455	86	10	dcfh	dcfh	NOUN
admet-2455	86	11	-	-	PUNCT
admet-2455	86	12	da	da	NOUN
admet-2455	86	13	for	for	ADP
admet-2455	86	14	30	30	NUM
admet-2455	86	15	min	min	NOUN
admet-2455	86	16	,	,	PUNCT
admet-2455	86	17	followed	follow	VERB
admet-2455	86	18	by	by	ADP
admet-2455	86	19	three	three	NUM
admet-2455	86	20	washes	wash	NOUN
admet-2455	86	21	with	with	ADP
admet-2455	86	22	culture	culture	NOUN
admet-2455	86	23	medium	medium	NOUN
admet-2455	86	24	without	without	ADP
admet-2455	86	25	fbs	fbs	PROPN
admet-2455	86	26	.	.	PUNCT
admet-2455	87	1	after	after	ADP
admet-2455	87	2	drug	drug	NOUN
admet-2455	87	3	treatment	treatment	NOUN
admet-2455	87	4	,	,	PUNCT
admet-2455	87	5	the	the	DET
admet-2455	87	6	fluorescence	fluorescence	NOUN
admet-2455	87	7	intensity	intensity	NOUN
admet-2455	87	8	was	be	AUX
admet-2455	87	9	measured	measure	VERB
admet-2455	87	10	using	use	VERB
admet-2455	87	11	the	the	DET
admet-2455	87	12	spectramax	spectramax	NOUN
admet-2455	87	13	m5	m5	PROPN
admet-2455	87	14	microplate	microplate	NOUN
admet-2455	87	15	reader	reader	NOUN
admet-2455	87	16	with	with	ADP
admet-2455	87	17	excitation	excitation	NOUN
admet-2455	87	18	wavelength	wavelength	NOUN
admet-2455	87	19	set	set	VERB
admet-2455	87	20	at	at	ADP
admet-2455	87	21	488	488	NUM
admet-2455	87	22	nm	nm	NOUN
admet-2455	87	23	and	and	CCONJ
admet-2455	87	24	emission	emission	NOUN
admet-2455	87	25	wavelength	wavelength	NOUN
admet-2455	87	26	set	set	VERB
admet-2455	87	27	at	at	ADP
admet-2455	87	28	525	525	NUM
admet-2455	87	29	nm	nm	NOUN
admet-2455	87	30	.	.	PUNCT
admet-2455	88	1	the	the	DET
admet-2455	88	2	results	result	NOUN
admet-2455	88	3	were	be	AUX
admet-2455	88	4	expressed	express	VERB
admet-2455	88	5	as	as	ADP
admet-2455	88	6	the	the	DET
admet-2455	88	7	fold	fold	ADJ
admet-2455	88	8	change	change	NOUN
admet-2455	88	9	in	in	ADP
admet-2455	88	10	fluorescence	fluorescence	ADJ
admet-2455	88	11	intensity	intensity	NOUN
admet-2455	88	12	relative	relative	ADJ
admet-2455	88	13	to	to	ADP
admet-2455	88	14	the	the	DET
admet-2455	88	15	control	control	NOUN
admet-2455	88	16	group	group	NOUN
admet-2455	88	17	.	.	PUNCT
admet-2455	89	1	jc1	jc1	PROPN
admet-2455	89	2	assay	assay	VERB
admet-2455	89	3	to	to	PART
admet-2455	89	4	detect	detect	VERB
admet-2455	89	5	mitochondrial	mitochondrial	ADJ
admet-2455	89	6	depolarization	depolarization	NOUN
admet-2455	89	7	flow	flow	NOUN
admet-2455	89	8	cytometry	cytometry	NOUN
admet-2455	89	9	assay	assay	NOUN
admet-2455	89	10	was	be	AUX
admet-2455	89	11	performed	perform	VERB
admet-2455	89	12	to	to	PART
admet-2455	89	13	detect	detect	VERB
admet-2455	89	14	the	the	DET
admet-2455	89	15	mitochondrial	mitochondrial	ADJ
admet-2455	89	16	membrane	membrane	NOUN
admet-2455	89	17	potential	potential	NOUN
admet-2455	89	18	(	(	PUNCT
admet-2455	89	19	mmp	mmp	PROPN
admet-2455	89	20	,	,	PUNCT
admet-2455	89	21	δψm	δψm	PROPN
admet-2455	89	22	)	)	PUNCT
admet-2455	89	23	using	use	VERB
admet-2455	89	24	jc-1	jc-1	NOUN
admet-2455	89	25	staining	stain	VERB
admet-2455	89	26	.	.	PUNCT
admet-2455	90	1	cells	cell	NOUN
admet-2455	90	2	were	be	AUX
admet-2455	90	3	washed	wash	VERB
admet-2455	90	4	twice	twice	ADV
admet-2455	90	5	with	with	ADP
admet-2455	90	6	pbs	pbs	PROPN
admet-2455	90	7	after	after	ADP
admet-2455	90	8	designed	design	VERB
admet-2455	90	9	treatment	treatment	NOUN
admet-2455	90	10	,	,	PUNCT
admet-2455	90	11	then	then	ADV
admet-2455	90	12	incubated	incubate	VERB
admet-2455	90	13	with	with	ADP
admet-2455	90	14	whole	whole	ADJ
admet-2455	90	15	culture	culture	NOUN
admet-2455	90	16	medium	medium	NOUN
admet-2455	90	17	containing	contain	VERB
admet-2455	90	18	appropriate	appropriate	ADJ
admet-2455	90	19	concentration	concentration	NOUN
admet-2455	90	20	of	of	ADP
admet-2455	90	21	5,5’,6,6’-tetrachloro-1,1’,3,3’-tetraethylbenzimidazolylcarbocyanine	5,5’,6,6’-tetrachloro-1,1’,3,3’-tetraethylbenzimidazolylcarbocyanine	NUM
admet-2455	90	22	iodide	iodide	NOUN
admet-2455	90	23	(	(	PUNCT
admet-2455	90	24	jc-1	jc-1	NOUN
admet-2455	90	25	)	)	PUNCT
admet-2455	90	26	(	(	PUNCT
admet-2455	90	27	sigma	sigma	PROPN
admet-2455	90	28	aldrich	aldrich	PROPN
admet-2455	90	29	,	,	PUNCT
admet-2455	90	30	usa	usa	PROPN
admet-2455	90	31	)	)	PUNCT
admet-2455	90	32	for	for	ADP
admet-2455	90	33	15	15	NUM
admet-2455	90	34	min	min	NOUN
admet-2455	90	35	at	at	ADP
admet-2455	90	36	a	a	DET
admet-2455	90	37	37	37	NUM
admet-2455	90	38	°	°	PROPN
admet-2455	90	39	c	c	NOUN
admet-2455	90	40	incubator	incubator	NOUN
admet-2455	90	41	.	.	PUNCT
admet-2455	91	1	then	then	ADV
admet-2455	91	2	the	the	DET
admet-2455	91	3	red	red	ADJ
admet-2455	91	4	and	and	CCONJ
admet-2455	91	5	green	green	ADJ
admet-2455	91	6	fluorescence	fluorescence	NOUN
admet-2455	91	7	signals	signal	NOUN
admet-2455	91	8	of	of	ADP
admet-2455	91	9	cells	cell	NOUN
admet-2455	91	10	were	be	AUX
admet-2455	91	11	analysed	analyse	VERB
admet-2455	91	12	by	by	ADP
admet-2455	91	13	the	the	DET
admet-2455	91	14	cyto	cyto	PROPN
admet-2455	91	15	-	-	PUNCT
admet-2455	91	16	flex	flex	ADJ
admet-2455	91	17	flow	flow	NOUN
admet-2455	91	18	cytometer	cytometer	NOUN
admet-2455	91	19	(	(	PUNCT
admet-2455	91	20	beckman	beckman	PROPN
admet-2455	91	21	coulter	coulter	PROPN
admet-2455	91	22	,	,	PUNCT
admet-2455	91	23	indianapolis	indianapolis	PROPN
admet-2455	91	24	,	,	PUNCT
admet-2455	91	25	in	in	ADP
admet-2455	91	26	,	,	PUNCT
admet-2455	91	27	usa	usa	PROPN
admet-2455	91	28	)	)	PUNCT
admet-2455	91	29	.	.	PUNCT
admet-2455	92	1	early	early	ADJ
admet-2455	92	2	and	and	CCONJ
admet-2455	92	3	late	late	ADJ
admet-2455	92	4	apoptosis	apoptosis	NOUN
admet-2455	92	5	detection	detection	NOUN
admet-2455	92	6	assay	assay	NOUN
admet-2455	92	7	cell	cell	NOUN
admet-2455	92	8	apoptosis	apoptosis	NOUN
admet-2455	92	9	proportion	proportion	NOUN
admet-2455	92	10	was	be	AUX
admet-2455	92	11	analysed	analyse	VERB
admet-2455	92	12	by	by	ADP
admet-2455	92	13	annexin	annexin	NOUN
admet-2455	92	14	v	v	ADP
admet-2455	92	15	-	-	PUNCT
admet-2455	92	16	fitc/	fitc/	NUM
admet-2455	92	17	propidium	propidium	NOUN
admet-2455	92	18	iodide	iodide	NOUN
admet-2455	92	19	(	(	PUNCT
admet-2455	92	20	pi	pi	NOUN
admet-2455	92	21	)	)	PUNCT
admet-2455	92	22	(	(	PUNCT
admet-2455	92	23	invitrogen	invitrogen	PROPN
admet-2455	92	24	,	,	PUNCT
admet-2455	92	25	ca	ca	PROPN
admet-2455	92	26	,	,	PUNCT
admet-2455	92	27	usa	usa	PROPN
admet-2455	92	28	)	)	PUNCT
admet-2455	92	29	dual	dual	ADJ
admet-2455	92	30	staining	stain	VERB
admet-2455	92	31	.	.	PUNCT
admet-2455	93	1	cell	cell	NOUN
admet-2455	93	2	samples	sample	NOUN
admet-2455	93	3	were	be	AUX
admet-2455	93	4	harvested	harvest	VERB
admet-2455	93	5	using	use	VERB
admet-2455	93	6	tryple	tryple	NOUN
admet-2455	93	7	(	(	PUNCT
admet-2455	93	8	gibco	gibco	NOUN
admet-2455	93	9	,	,	PUNCT
admet-2455	93	10	thermo	thermo	NOUN
admet-2455	93	11	fisher	fisher	PROPN
admet-2455	93	12	scientific	scientific	PROPN
admet-2455	93	13	,	,	PUNCT
admet-2455	93	14	usa	usa	PROPN
admet-2455	93	15	)	)	PUNCT
admet-2455	93	16	and	and	CCONJ
admet-2455	93	17	washed	wash	VERB
admet-2455	93	18	with	with	ADP
admet-2455	93	19	cold	cold	ADJ
admet-2455	93	20	pbs	pbs	PROPN
admet-2455	93	21	for	for	ADP
admet-2455	93	22	two	two	NUM
admet-2455	93	23	times	time	NOUN
admet-2455	93	24	.	.	PUNCT
admet-2455	94	1	then	then	ADV
admet-2455	94	2	cell	cell	NOUN
admet-2455	94	3	pellets	pellet	NOUN
admet-2455	94	4	were	be	AUX
admet-2455	94	5	immediately	immediately	ADV
admet-2455	94	6	suspended	suspend	VERB
admet-2455	94	7	in	in	ADP
admet-2455	94	8	500	500	NUM
admet-2455	94	9	μl	μl	ADP
admet-2455	94	10	binding	bind	VERB
admet-2455	94	11	buffer	buffer	NOUN
admet-2455	94	12	which	which	PRON
admet-2455	94	13	containing	contain	VERB
admet-2455	94	14	5μl	5μl	NOUN
admet-2455	94	15	of	of	ADP
admet-2455	94	16	annexin	annexin	NOUN
admet-2455	94	17	v	v	NOUN
admet-2455	94	18	-	-	PUNCT
admet-2455	94	19	fitc	fitc	NOUN
admet-2455	94	20	and	and	CCONJ
admet-2455	94	21	10	10	NUM
admet-2455	94	22	μl	μl	ADP
admet-2455	94	23	of	of	ADP
admet-2455	94	24	pi	pi	NOUN
admet-2455	94	25	(	(	PUNCT
admet-2455	94	26	fitc	fitc	PROPN
admet-2455	94	27	annexin	annexin	NOUN
admet-2455	94	28	-	-	PUNCT
admet-2455	94	29	v	v	NOUN
admet-2455	94	30	apoptotic	apoptotic	ADJ
admet-2455	94	31	detection	detection	NOUN
admet-2455	94	32	kit	kit	PROPN
admet-2455	94	33	,	,	PUNCT
admet-2455	94	34	bio	bio	PROPN
admet-2455	94	35	legend	legend	PROPN
admet-2455	94	36	)	)	PUNCT
admet-2455	94	37	.	.	PUNCT
admet-2455	95	1	after	after	ADP
admet-2455	95	2	15	15	NUM
admet-2455	95	3	min	min	NOUN
admet-2455	95	4	incubation	incubation	NOUN
admet-2455	95	5	at	at	ADP
admet-2455	95	6	room	room	NOUN
admet-2455	95	7	temperature	temperature	NOUN
admet-2455	95	8	,	,	PUNCT
admet-2455	95	9	cell	cell	NOUN
admet-2455	95	10	samples	sample	NOUN
admet-2455	95	11	were	be	AUX
admet-2455	95	12	analyzed	analyze	VERB
admet-2455	95	13	by	by	ADP
admet-2455	95	14	the	the	DET
admet-2455	95	15	cyto	cyto	PROPN
admet-2455	95	16	-	-	PUNCT
admet-2455	95	17	flex	flex	ADJ
admet-2455	95	18	flow	flow	NOUN
admet-2455	95	19	cytometer	cytometer	NOUN
admet-2455	95	20	(	(	PUNCT
admet-2455	95	21	beckman	beckman	PROPN
admet-2455	95	22	coulter	coulter	PROPN
admet-2455	95	23	,	,	PUNCT
admet-2455	95	24	indianapolis	indianapolis	PROPN
admet-2455	95	25	,	,	PUNCT
admet-2455	95	26	in	in	ADP
admet-2455	95	27	,	,	PUNCT
admet-2455	95	28	usa	usa	PROPN
admet-2455	95	29	)	)	PUNCT
admet-2455	95	30	.	.	PUNCT
admet-2455	96	1	admet	admet	PROPN
admet-2455	96	2	&	&	CCONJ
admet-2455	96	3	dmpk	dmpk	PROPN
admet-2455	96	4	12(6	12(6	NUM
admet-2455	96	5	)	)	PUNCT
admet-2455	96	6	(	(	PUNCT
admet-2455	96	7	2024	2024	NUM
admet-2455	96	8	)	)	PUNCT
admet-2455	96	9	821	821	NUM
admet-2455	96	10	-	-	SYM
admet-2455	96	11	841	841	NUM
admet-2455	96	12	targeting	targeting	NOUN
admet-2455	96	13	hexokinase	hexokinase	NOUN
admet-2455	96	14	2	2	NUM
admet-2455	96	15	to	to	PART
admet-2455	96	16	enhance	enhance	VERB
admet-2455	96	17	anticancer	anticancer	NOUN
admet-2455	96	18	efficacy	efficacy	NOUN
admet-2455	96	19	of	of	ADP
admet-2455	96	20	trichosanthin	trichosanthin	PROPN
admet-2455	96	21	doi	doi	PROPN
admet-2455	96	22	:	:	PUNCT
admet-2455	96	23	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	NUM
admet-2455	96	24	825	825	NUM
admet-2455	96	25	western	western	ADJ
admet-2455	96	26	blot	blot	NOUN
admet-2455	96	27	target	target	NOUN
admet-2455	96	28	proteins	protein	NOUN
admet-2455	96	29	were	be	AUX
admet-2455	96	30	separated	separate	VERB
admet-2455	96	31	on	on	ADP
admet-2455	96	32	10	10	NUM
admet-2455	96	33	%	%	NOUN
admet-2455	96	34	sds	sds	NOUN
admet-2455	96	35	-	-	PUNCT
admet-2455	96	36	page	page	NOUN
admet-2455	96	37	,	,	PUNCT
admet-2455	96	38	then	then	ADV
admet-2455	96	39	electrophoretically	electrophoretically	ADV
admet-2455	96	40	transferred	transfer	VERB
admet-2455	96	41	to	to	ADP
admet-2455	96	42	a	a	DET
admet-2455	96	43	nitrocellulose	nitrocellulose	NOUN
admet-2455	96	44	membrane	membrane	NOUN
admet-2455	96	45	at	at	ADP
admet-2455	96	46	4	4	NUM
admet-2455	96	47	°	°	ADP
admet-2455	96	48	c	c	NOUN
admet-2455	96	49	for	for	ADP
admet-2455	96	50	12	12	NUM
admet-2455	96	51	h	h	NOUN
admet-2455	96	52	by	by	ADP
admet-2455	96	53	the	the	DET
admet-2455	96	54	trans	trans	PROPN
admet-2455	96	55	-	-	PROPN
admet-2455	96	56	blot	blot	ADJ
admet-2455	96	57	system	system	NOUN
admet-2455	96	58	(	(	PUNCT
admet-2455	96	59	bio	bio	NOUN
admet-2455	96	60	-	-	PROPN
admet-2455	96	61	rad	rad	PROPN
admet-2455	96	62	,	,	PUNCT
admet-2455	96	63	usa	usa	PROPN
admet-2455	96	64	)	)	PUNCT
admet-2455	96	65	.	.	PUNCT
admet-2455	97	1	the	the	DET
admet-2455	97	2	membrane	membrane	NOUN
admet-2455	97	3	was	be	AUX
admet-2455	97	4	blocked	block	VERB
admet-2455	97	5	in	in	ADP
admet-2455	97	6	5	5	NUM
admet-2455	97	7	%	%	NOUN
admet-2455	97	8	bsa	bsa	NOUN
admet-2455	97	9	for	for	ADP
admet-2455	97	10	1	1	NUM
admet-2455	97	11	h	h	NOUN
admet-2455	97	12	and	and	CCONJ
admet-2455	97	13	then	then	ADV
admet-2455	97	14	washed	wash	VERB
admet-2455	97	15	3	3	NUM
admet-2455	97	16	times	time	NOUN
admet-2455	97	17	with	with	ADP
admet-2455	97	18	tbst	tbst	NOUN
admet-2455	97	19	before	before	ADP
admet-2455	97	20	probed	probe	VERB
admet-2455	97	21	with	with	ADP
admet-2455	97	22	specific	specific	ADJ
admet-2455	97	23	primary	primary	ADJ
admet-2455	97	24	antibodies	antibody	NOUN
admet-2455	97	25	overnight	overnight	ADV
admet-2455	97	26	at	at	ADP
admet-2455	97	27	4	4	NUM
admet-2455	97	28	°	°	NOUN
admet-2455	97	29	c	c	NOUN
admet-2455	97	30	.	.	PUNCT
admet-2455	98	1	after	after	ADP
admet-2455	98	2	that	that	PRON
admet-2455	98	3	,	,	PUNCT
admet-2455	98	4	the	the	DET
admet-2455	98	5	membrane	membrane	NOUN
admet-2455	98	6	was	be	AUX
admet-2455	98	7	washed	wash	VERB
admet-2455	98	8	and	and	CCONJ
admet-2455	98	9	reacted	react	VERB
admet-2455	98	10	with	with	ADP
admet-2455	98	11	appropriate	appropriate	ADJ
admet-2455	98	12	secondary	secondary	ADJ
admet-2455	98	13	antibodies	antibody	NOUN
admet-2455	98	14	which	which	PRON
admet-2455	98	15	were	be	AUX
admet-2455	98	16	used	use	VERB
admet-2455	98	17	to	to	PART
admet-2455	98	18	detect	detect	VERB
admet-2455	98	19	the	the	DET
admet-2455	98	20	target	target	NOUN
admet-2455	98	21	proteins	protein	NOUN
admet-2455	98	22	.	.	PUNCT
admet-2455	99	1	finally	finally	ADV
admet-2455	99	2	,	,	PUNCT
admet-2455	99	3	the	the	DET
admet-2455	99	4	proteins	protein	NOUN
admet-2455	99	5	of	of	ADP
admet-2455	99	6	samples	sample	NOUN
admet-2455	99	7	were	be	AUX
admet-2455	99	8	visualized	visualize	VERB
admet-2455	99	9	by	by	ADP
admet-2455	99	10	a	a	DET
admet-2455	99	11	chemidocs	chemidoc	NOUN
admet-2455	99	12	mp	mp	PROPN
admet-2455	99	13	imaging	imaging	NOUN
admet-2455	99	14	system	system	NOUN
admet-2455	99	15	(	(	PUNCT
admet-2455	99	16	bio	bio	NOUN
admet-2455	99	17	-	-	PROPN
admet-2455	99	18	rad	rad	PROPN
admet-2455	99	19	,	,	PUNCT
admet-2455	99	20	usa	usa	PROPN
admet-2455	99	21	)	)	PUNCT
admet-2455	99	22	.	.	PUNCT
admet-2455	100	1	rna	rna	NOUN
admet-2455	100	2	-	-	PUNCT
admet-2455	100	3	sequencing	sequence	VERB
admet-2455	100	4	analysis	analysis	NOUN
admet-2455	100	5	the	the	DET
admet-2455	100	6	total	total	ADJ
admet-2455	100	7	rna	rna	NOUN
admet-2455	100	8	of	of	ADP
admet-2455	100	9	hela	hela	PROPN
admet-2455	100	10	cells	cell	NOUN
admet-2455	100	11	after	after	SCONJ
admet-2455	100	12	designed	design	VERB
admet-2455	100	13	treatments	treatment	NOUN
admet-2455	100	14	were	be	AUX
admet-2455	100	15	extracted	extract	VERB
admet-2455	100	16	following	follow	VERB
admet-2455	100	17	the	the	DET
admet-2455	100	18	manufacturing	manufacturing	NOUN
admet-2455	100	19	instructions	instruction	NOUN
admet-2455	100	20	.	.	PUNCT
admet-2455	101	1	briefly	briefly	ADV
admet-2455	101	2	,	,	PUNCT
admet-2455	101	3	after	after	ADP
admet-2455	101	4	washing	wash	VERB
admet-2455	101	5	with	with	ADP
admet-2455	101	6	pbs	pbs	PROPN
admet-2455	101	7	,	,	PUNCT
admet-2455	101	8	cells	cell	NOUN
admet-2455	101	9	in	in	ADP
admet-2455	101	10	6	6	NUM
admet-2455	101	11	-	-	PUNCT
admet-2455	101	12	well	well	NOUN
admet-2455	101	13	plates	plate	NOUN
admet-2455	101	14	were	be	AUX
admet-2455	101	15	added	add	VERB
admet-2455	101	16	with	with	ADP
admet-2455	101	17	500	500	NUM
admet-2455	101	18	μl	μl	ADJ
admet-2455	101	19	/	/	SYM
admet-2455	101	20	well	well	NOUN
admet-2455	101	21	rnaiso	rnaiso	NOUN
admet-2455	101	22	plus	plus	CCONJ
admet-2455	101	23	reagent	reagent	NOUN
admet-2455	101	24	and	and	CCONJ
admet-2455	101	25	vigorously	vigorously	ADV
admet-2455	101	26	pipetted	pipette	VERB
admet-2455	101	27	to	to	PART
admet-2455	101	28	dissolve	dissolve	VERB
admet-2455	101	29	completely	completely	ADV
admet-2455	101	30	.	.	PUNCT
admet-2455	102	1	then	then	ADV
admet-2455	102	2	samples	sample	NOUN
admet-2455	102	3	were	be	AUX
admet-2455	102	4	sent	send	VERB
admet-2455	102	5	to	to	ADP
admet-2455	102	6	the	the	DET
admet-2455	102	7	novogene	novogene	NOUN
admet-2455	102	8	(	(	PUNCT
admet-2455	102	9	beijing	beijing	PROPN
admet-2455	102	10	,	,	PUNCT
admet-2455	102	11	china	china	PROPN
admet-2455	102	12	)	)	PUNCT
admet-2455	102	13	for	for	ADP
admet-2455	102	14	performing	perform	VERB
admet-2455	102	15	rna	rna	NOUN
admet-2455	102	16	sequence	sequence	NOUN
admet-2455	102	17	analysis	analysis	NOUN
admet-2455	102	18	.	.	PUNCT
admet-2455	103	1	cellular	cellular	ADJ
admet-2455	103	2	atp	atp	PROPN
admet-2455	103	3	measurement	measurement	NOUN
admet-2455	103	4	cells	cell	NOUN
admet-2455	103	5	were	be	AUX
admet-2455	103	6	prepared	prepare	VERB
admet-2455	103	7	according	accord	VERB
admet-2455	103	8	to	to	ADP
admet-2455	103	9	the	the	DET
admet-2455	103	10	manufacturer	manufacturer	NOUN
admet-2455	103	11	's	's	PART
admet-2455	103	12	instructions	instruction	NOUN
admet-2455	103	13	provided	provide	VERB
admet-2455	103	14	by	by	ADP
admet-2455	103	15	the	the	DET
admet-2455	103	16	cellular	cellular	ADJ
admet-2455	103	17	atp	atp	PROPN
admet-2455	103	18	test	test	NOUN
admet-2455	103	19	kit	kit	NOUN
admet-2455	103	20	(	(	PUNCT
admet-2455	103	21	beyotime	beyotime	NOUN
admet-2455	103	22	,	,	PUNCT
admet-2455	103	23	china	china	PROPN
admet-2455	103	24	)	)	PUNCT
admet-2455	103	25	.	.	PUNCT
admet-2455	104	1	briefly	briefly	ADV
admet-2455	104	2	,	,	PUNCT
admet-2455	104	3	triplicates	triplicate	NOUN
admet-2455	104	4	of	of	ADP
admet-2455	104	5	samples	sample	NOUN
admet-2455	104	6	or	or	CCONJ
admet-2455	104	7	atp	atp	PROPN
admet-2455	104	8	standard	standard	PROPN
admet-2455	104	9	solutions	solution	NOUN
admet-2455	104	10	were	be	AUX
admet-2455	104	11	dispensed	dispense	VERB
admet-2455	104	12	into	into	ADP
admet-2455	104	13	a	a	DET
admet-2455	104	14	96	96	NUM
admet-2455	104	15	-	-	PUNCT
admet-2455	104	16	well	well	NOUN
admet-2455	104	17	microplate	microplate	NOUN
admet-2455	104	18	.	.	PUNCT
admet-2455	105	1	the	the	DET
admet-2455	105	2	atp	atp	PROPN
admet-2455	105	3	assay	assay	VERB
admet-2455	105	4	reagent	reagent	NOUN
admet-2455	105	5	from	from	ADP
admet-2455	105	6	the	the	DET
admet-2455	105	7	kit	kit	NOUN
admet-2455	105	8	was	be	AUX
admet-2455	105	9	added	add	VERB
admet-2455	105	10	to	to	ADP
admet-2455	105	11	each	each	DET
admet-2455	105	12	well	well	ADV
admet-2455	105	13	and	and	CCONJ
admet-2455	105	14	mixed	mixed	ADJ
admet-2455	105	15	thoroughly	thoroughly	ADV
admet-2455	105	16	.	.	PUNCT
admet-2455	106	1	luminescence	luminescence	NOUN
admet-2455	106	2	signal	signal	NOUN
admet-2455	106	3	was	be	AUX
admet-2455	106	4	measured	measure	VERB
admet-2455	106	5	using	use	VERB
admet-2455	106	6	a	a	DET
admet-2455	106	7	luminometer	luminometer	NOUN
admet-2455	106	8	-	-	PUNCT
admet-2455	106	9	equipped	equip	VERB
admet-2455	106	10	spectramax	spectramax	NOUN
admet-2455	106	11	m5	m5	PROPN
admet-2455	106	12	microplate	microplate	NOUN
admet-2455	106	13	reader	reader	PROPN
admet-2455	106	14	.	.	PUNCT
admet-2455	107	1	atp	atp	PROPN
admet-2455	107	2	levels	level	NOUN
admet-2455	107	3	were	be	AUX
admet-2455	107	4	recorded	record	VERB
admet-2455	107	5	and	and	CCONJ
admet-2455	107	6	normalized	normalize	VERB
admet-2455	107	7	to	to	PART
admet-2455	107	8	sample	sample	VERB
admet-2455	107	9	protein	protein	NOUN
admet-2455	107	10	concentration	concentration	NOUN
admet-2455	107	11	.	.	PUNCT
admet-2455	108	1	hexokinase	hexokinase	NOUN
admet-2455	108	2	activity	activity	NOUN
admet-2455	108	3	assay	assay	VERB
admet-2455	108	4	the	the	DET
admet-2455	108	5	hexokinase	hexokinase	NOUN
admet-2455	108	6	activities	activity	NOUN
admet-2455	108	7	were	be	AUX
admet-2455	108	8	measured	measure	VERB
admet-2455	108	9	using	use	VERB
admet-2455	108	10	a	a	DET
admet-2455	108	11	hexokinase	hexokinase	NOUN
admet-2455	108	12	(	(	PUNCT
admet-2455	108	13	hk	hk	NOUN
admet-2455	108	14	)	)	PUNCT
admet-2455	108	15	activity	activity	NOUN
admet-2455	108	16	assay	assay	NOUN
admet-2455	108	17	kit	kit	NOUN
admet-2455	108	18	(	(	PUNCT
admet-2455	108	19	solarbio	solarbio	NOUN
admet-2455	108	20	,	,	PUNCT
admet-2455	108	21	china	china	PROPN
admet-2455	108	22	)	)	PUNCT
admet-2455	108	23	.	.	PUNCT
admet-2455	109	1	experiments	experiment	NOUN
admet-2455	109	2	were	be	AUX
admet-2455	109	3	conducted	conduct	VERB
admet-2455	109	4	as	as	ADP
admet-2455	109	5	manufacturer	manufacturer	NOUN
admet-2455	109	6	instructions	instruction	NOUN
admet-2455	109	7	.	.	PUNCT
admet-2455	110	1	finally	finally	ADV
admet-2455	110	2	,	,	PUNCT
admet-2455	110	3	the	the	DET
admet-2455	110	4	absorption	absorption	NOUN
admet-2455	110	5	values	value	NOUN
admet-2455	110	6	of	of	ADP
admet-2455	110	7	the	the	DET
admet-2455	110	8	cell	cell	NOUN
admet-2455	110	9	samples	sample	NOUN
admet-2455	110	10	were	be	AUX
admet-2455	110	11	read	read	VERB
admet-2455	110	12	at	at	ADP
admet-2455	110	13	340	340	NUM
admet-2455	110	14	nm	nm	NOUN
admet-2455	110	15	by	by	ADP
admet-2455	110	16	the	the	DET
admet-2455	110	17	spectra	spectra	ADJ
admet-2455	110	18	max	max	PROPN
admet-2455	110	19	m5	m5	PROPN
admet-2455	110	20	microplate	microplate	NOUN
admet-2455	110	21	reader	reader	NOUN
admet-2455	110	22	(	(	PUNCT
admet-2455	110	23	molecular	molecular	ADJ
admet-2455	110	24	devices	device	NOUN
admet-2455	110	25	,	,	PUNCT
admet-2455	110	26	usa	usa	PROPN
admet-2455	110	27	)	)	PUNCT
admet-2455	110	28	.	.	PUNCT
admet-2455	111	1	isolation	isolation	NOUN
admet-2455	111	2	of	of	ADP
admet-2455	111	3	nuclei	nucleus	NOUN
admet-2455	111	4	from	from	ADP
admet-2455	111	5	cells	cell	NOUN
admet-2455	111	6	the	the	DET
admet-2455	111	7	separation	separation	NOUN
admet-2455	111	8	of	of	ADP
admet-2455	111	9	nuclei	nucleus	NOUN
admet-2455	111	10	from	from	ADP
admet-2455	111	11	cells	cell	NOUN
admet-2455	111	12	was	be	AUX
admet-2455	111	13	conducted	conduct	VERB
admet-2455	111	14	as	as	ADP
admet-2455	111	15	previously	previously	ADV
admet-2455	111	16	published	publish	VERB
admet-2455	111	17	protocol	protocol	NOUN
admet-2455	111	18	[	[	X
admet-2455	111	19	29	29	NUM
admet-2455	111	20	]	]	PUNCT
admet-2455	111	21	.	.	PUNCT
admet-2455	112	1	in	in	ADP
admet-2455	112	2	brief	brief	NOUN
admet-2455	112	3	,	,	PUNCT
admet-2455	112	4	the	the	DET
admet-2455	112	5	dissociated	dissociate	VERB
admet-2455	112	6	cells	cell	NOUN
admet-2455	112	7	were	be	AUX
admet-2455	112	8	transferred	transfer	VERB
admet-2455	112	9	to	to	ADP
admet-2455	112	10	a	a	DET
admet-2455	112	11	1.5	1.5	NUM
admet-2455	112	12	ml	ml	NOUN
admet-2455	112	13	microcentrifuge	microcentrifuge	ADJ
admet-2455	112	14	tube	tube	NOUN
admet-2455	112	15	kept	keep	VERB
admet-2455	112	16	on	on	ADP
admet-2455	112	17	ice	ice	NOUN
admet-2455	112	18	.	.	PUNCT
admet-2455	113	1	after	after	ADP
admet-2455	113	2	centrifugation	centrifugation	NOUN
admet-2455	113	3	,	,	PUNCT
admet-2455	113	4	the	the	DET
admet-2455	113	5	supernatant	supernatant	NOUN
admet-2455	113	6	was	be	AUX
admet-2455	113	7	removed	remove	VERB
admet-2455	113	8	,	,	PUNCT
admet-2455	113	9	and	and	CCONJ
admet-2455	113	10	the	the	DET
admet-2455	113	11	cell	cell	NOUN
admet-2455	113	12	pellet	pellet	NOUN
admet-2455	113	13	was	be	AUX
admet-2455	113	14	resuspended	resuspend	VERB
admet-2455	113	15	in	in	ADP
admet-2455	113	16	ice	ice	NOUN
admet-2455	113	17	-	-	PUNCT
admet-2455	113	18	cold	cold	ADJ
admet-2455	113	19	hypertonic	hypertonic	ADJ
admet-2455	113	20	buffer	buffer	NOUN
admet-2455	113	21	containing	contain	VERB
admet-2455	113	22	0.1	0.1	NUM
admet-2455	113	23	%	%	NOUN
admet-2455	113	24	np40	np40	PROPN
admet-2455	113	25	.	.	PUNCT
admet-2455	114	1	the	the	DET
admet-2455	114	2	sample	sample	NOUN
admet-2455	114	3	was	be	AUX
admet-2455	114	4	gently	gently	ADV
admet-2455	114	5	mixed	mixed	ADJ
admet-2455	114	6	and	and	CCONJ
admet-2455	114	7	triturated	triturate	VERB
admet-2455	114	8	,	,	PUNCT
admet-2455	114	9	followed	follow	VERB
admet-2455	114	10	by	by	ADP
admet-2455	114	11	centrifugation	centrifugation	NOUN
admet-2455	114	12	at	at	ADP
admet-2455	114	13	10,000	10,000	NUM
admet-2455	114	14	rpm	rpm	NOUN
admet-2455	114	15	for	for	ADP
admet-2455	114	16	10	10	NUM
admet-2455	114	17	min	min	NOUN
admet-2455	114	18	.	.	PUNCT
admet-2455	115	1	the	the	DET
admet-2455	115	2	supernatant	supernatant	NOUN
admet-2455	115	3	was	be	AUX
admet-2455	115	4	discarded	discard	VERB
admet-2455	115	5	,	,	PUNCT
admet-2455	115	6	leaving	leave	VERB
admet-2455	115	7	behind	behind	ADP
admet-2455	115	8	white	white	ADJ
admet-2455	115	9	pelleted	pellete	VERB
admet-2455	115	10	nuclei	nucleus	NOUN
admet-2455	115	11	,	,	PUNCT
admet-2455	115	12	which	which	PRON
admet-2455	115	13	were	be	AUX
admet-2455	115	14	than	than	SCONJ
admet-2455	115	15	isolated	isolate	VERB
admet-2455	115	16	from	from	ADP
admet-2455	115	17	the	the	DET
admet-2455	115	18	yellowish	yellowish	ADJ
admet-2455	115	19	pellets	pellet	NOUN
admet-2455	115	20	of	of	ADP
admet-2455	115	21	whole	whole	ADJ
admet-2455	115	22	cells	cell	NOUN
admet-2455	115	23	.	.	PUNCT
admet-2455	116	1	the	the	DET
admet-2455	116	2	isolated	isolated	ADJ
admet-2455	116	3	nuclei	nucleus	NOUN
admet-2455	116	4	were	be	AUX
admet-2455	116	5	further	far	ADV
admet-2455	116	6	utilized	utilize	VERB
admet-2455	116	7	for	for	ADP
admet-2455	116	8	a	a	DET
admet-2455	116	9	variety	variety	NOUN
admet-2455	116	10	of	of	ADP
admet-2455	116	11	downstream	downstream	ADJ
admet-2455	116	12	western	western	ADJ
admet-2455	116	13	blotting	blot	VERB
admet-2455	116	14	experiments	experiment	NOUN
admet-2455	116	15	.	.	PUNCT
admet-2455	117	1	in	in	ADP
admet-2455	117	2	vivo	vivo	ADJ
admet-2455	117	3	xenograft	xenograft	NOUN
admet-2455	117	4	study	study	VERB
admet-2455	117	5	the	the	DET
admet-2455	117	6	animal	animal	NOUN
admet-2455	117	7	research	research	NOUN
admet-2455	117	8	ethics	ethic	NOUN
admet-2455	117	9	committee	committee	PROPN
admet-2455	117	10	of	of	ADP
admet-2455	117	11	the	the	DET
admet-2455	117	12	university	university	PROPN
admet-2455	117	13	of	of	ADP
admet-2455	117	14	macau	macau	PROPN
admet-2455	117	15	authorized	authorize	VERB
admet-2455	117	16	and	and	CCONJ
admet-2455	117	17	guided	guide	VERB
admet-2455	117	18	all	all	DET
admet-2455	117	19	animal	animal	NOUN
admet-2455	117	20	studies	study	NOUN
admet-2455	117	21	,	,	PUNCT
admet-2455	117	22	which	which	PRON
admet-2455	117	23	followed	follow	VERB
admet-2455	117	24	the	the	DET
admet-2455	117	25	approved	approve	VERB
admet-2455	117	26	protocol	protocol	NOUN
admet-2455	117	27	(	(	PUNCT
admet-2455	117	28	umare-008	umare-008	NOUN
admet-2455	117	29	-	-	PUNCT
admet-2455	117	30	2022	2022	NUM
admet-2455	117	31	;	;	PUNCT
admet-2455	117	32	approved	approve	VERB
admet-2455	117	33	date	date	NOUN
admet-2455	117	34	:	:	PUNCT
admet-2455	117	35	17	17	NUM
admet-2455	117	36	-	-	SYM
admet-2455	117	37	05	05	NUM
admet-2455	117	38	-	-	PUNCT
admet-2455	117	39	2022	2022	NUM
admet-2455	117	40	)	)	PUNCT
admet-2455	117	41	that	that	PRON
admet-2455	117	42	was	be	AUX
admet-2455	117	43	in	in	ADP
admet-2455	117	44	compliance	compliance	NOUN
admet-2455	117	45	with	with	ADP
admet-2455	117	46	the	the	DET
admet-2455	117	47	u.k	u.k	PROPN
admet-2455	117	48	.	.	PROPN
admet-2455	117	49	animals	animal	NOUN
admet-2455	117	50	(	(	PUNCT
admet-2455	117	51	scientific	scientific	ADJ
admet-2455	117	52	procedures	procedure	NOUN
admet-2455	117	53	)	)	PUNCT
admet-2455	117	54	act	act	PROPN
admet-2455	117	55	,	,	PUNCT
admet-2455	117	56	1986	1986	NUM
admet-2455	117	57	and	and	CCONJ
admet-2455	117	58	associated	associated	ADJ
admet-2455	117	59	guidelines	guideline	NOUN
admet-2455	117	60	.	.	PUNCT
admet-2455	118	1	female	female	ADJ
admet-2455	118	2	nude	nude	ADJ
admet-2455	118	3	mice	mouse	NOUN
admet-2455	118	4	,	,	PUNCT
admet-2455	118	5	aged	age	VERB
admet-2455	118	6	6	6	NUM
admet-2455	118	7	-	-	SYM
admet-2455	118	8	8	8	NUM
admet-2455	118	9	weeks	week	NOUN
admet-2455	118	10	,	,	PUNCT
admet-2455	118	11	were	be	AUX
admet-2455	118	12	procured	procure	VERB
admet-2455	118	13	from	from	ADP
admet-2455	118	14	the	the	DET
admet-2455	118	15	animal	animal	NOUN
admet-2455	118	16	core	core	NOUN
admet-2455	118	17	of	of	ADP
admet-2455	118	18	the	the	DET
admet-2455	118	19	university	university	PROPN
admet-2455	118	20	of	of	ADP
admet-2455	118	21	macau	macau	PROPN
admet-2455	118	22	and	and	CCONJ
admet-2455	118	23	kept	keep	VERB
admet-2455	118	24	in	in	ADP
admet-2455	118	25	a	a	DET
admet-2455	118	26	pathogen	pathogen	NOUN
admet-2455	118	27	-	-	PUNCT
admet-2455	118	28	free	free	ADJ
admet-2455	118	29	environment	environment	NOUN
admet-2455	118	30	.	.	PUNCT
admet-2455	119	1	to	to	PART
admet-2455	119	2	establish	establish	VERB
admet-2455	119	3	xenograft	xenograft	PROPN
admet-2455	119	4	tumour	tumour	PROPN
admet-2455	119	5	s	s	PROPN
admet-2455	119	6	,	,	PUNCT
admet-2455	119	7	scc25	scc25	PROPN
admet-2455	119	8	cells	cell	NOUN
admet-2455	119	9	(	(	PUNCT
admet-2455	119	10	around	around	ADP
admet-2455	119	11	8×106	8×106	NUM
admet-2455	119	12	cells	cell	NOUN
admet-2455	119	13	in	in	ADP
admet-2455	119	14	100	100	NUM
admet-2455	119	15	μl	μl	ADP
admet-2455	119	16	pbs	pbs	PROPN
admet-2455	119	17	)	)	PUNCT
admet-2455	119	18	were	be	AUX
admet-2455	119	19	subcutaneously	subcutaneously	ADV
admet-2455	119	20	injected	inject	VERB
admet-2455	119	21	into	into	ADP
admet-2455	119	22	the	the	DET
admet-2455	119	23	right	right	ADJ
admet-2455	119	24	flank	flank	NOUN
admet-2455	119	25	of	of	ADP
admet-2455	119	26	each	each	DET
admet-2455	119	27	mouse	mouse	NOUN
admet-2455	119	28	.	.	PUNCT
admet-2455	120	1	once	once	SCONJ
admet-2455	120	2	the	the	DET
admet-2455	120	3	tumour	tumour	NOUN
admet-2455	120	4	s	s	PART
admet-2455	120	5	reached	reach	VERB
admet-2455	120	6	a	a	DET
admet-2455	120	7	volume	volume	NOUN
admet-2455	120	8	of	of	ADP
admet-2455	120	9	approximately	approximately	ADV
admet-2455	120	10	100	100	NUM
admet-2455	120	11	mm3	mm3	ADJ
admet-2455	120	12	,	,	PUNCT
admet-2455	120	13	the	the	DET
admet-2455	120	14	mice	mouse	NOUN
admet-2455	120	15	were	be	AUX
admet-2455	120	16	randomly	randomly	ADV
admet-2455	120	17	divided	divide	VERB
admet-2455	120	18	into	into	ADP
admet-2455	120	19	five	five	NUM
admet-2455	120	20	groups	group	NOUN
admet-2455	120	21	(	(	PUNCT
admet-2455	120	22	n	n	NOUN
admet-2455	120	23	=	=	SYM
admet-2455	120	24	6	6	NUM
admet-2455	120	25	per	per	ADP
admet-2455	120	26	group	group	NOUN
admet-2455	120	27	)	)	PUNCT
admet-2455	120	28	and	and	CCONJ
admet-2455	120	29	treated	treat	VERB
admet-2455	120	30	with	with	ADP
admet-2455	120	31	vehicle	vehicle	NOUN
admet-2455	120	32	(	(	PUNCT
admet-2455	120	33	pbs	pbs	PROPN
admet-2455	120	34	containing	contain	VERB
admet-2455	120	35	10	10	NUM
admet-2455	120	36	%	%	NOUN
admet-2455	120	37	peg	peg	NOUN
admet-2455	120	38	)	)	PUNCT
admet-2455	120	39	,	,	PUNCT
admet-2455	120	40	tcs	tcs	NOUN
admet-2455	120	41	(	(	PUNCT
admet-2455	120	42	1	1	NUM
admet-2455	120	43	mg	mg	PROPN
admet-2455	120	44	/	/	SYM
admet-2455	120	45	kg	kg	PROPN
admet-2455	120	46	)	)	PUNCT
admet-2455	120	47	,	,	PUNCT
admet-2455	120	48	benz	benz	PROPN
admet-2455	120	49	(	(	PUNCT
admet-2455	120	50	500	500	NUM
admet-2455	120	51	mg	mg	NUM
admet-2455	120	52	/	/	SYM
admet-2455	120	53	kg	kg	PROPN
admet-2455	120	54	)	)	PUNCT
admet-2455	120	55	,	,	PUNCT
admet-2455	120	56	and	and	CCONJ
admet-2455	120	57	tcs	tcs	NOUN
admet-2455	120	58	combined	combine	VERB
admet-2455	120	59	with	with	ADP
admet-2455	120	60	benz	benz	PROPN
admet-2455	120	61	by	by	ADP
admet-2455	120	62	intraperitoneal	intraperitoneal	ADJ
admet-2455	120	63	injection	injection	NOUN
admet-2455	120	64	every	every	DET
admet-2455	120	65	other	other	ADJ
admet-2455	120	66	day	day	NOUN
admet-2455	120	67	for	for	ADP
admet-2455	120	68	19	19	NUM
admet-2455	120	69	days	day	NOUN
admet-2455	120	70	.	.	PUNCT
admet-2455	121	1	the	the	DET
admet-2455	121	2	body	body	NOUN
admet-2455	121	3	weight	weight	NOUN
admet-2455	121	4	and	and	CCONJ
admet-2455	121	5	general	general	ADJ
admet-2455	121	6	conditions	condition	NOUN
admet-2455	121	7	of	of	ADP
admet-2455	121	8	mice	mouse	NOUN
admet-2455	121	9	were	be	AUX
admet-2455	121	10	monitored	monitor	VERB
admet-2455	121	11	every	every	DET
admet-2455	121	12	two	two	NUM
admet-2455	121	13	days	day	NOUN
admet-2455	121	14	.	.	PUNCT
admet-2455	122	1	tumour	tumour	NOUN
admet-2455	122	2	s	s	VERB
admet-2455	122	3	was	be	AUX
admet-2455	122	4	measured	measure	VERB
admet-2455	122	5	every	every	DET
admet-2455	122	6	two	two	NUM
admet-2455	122	7	days	day	NOUN
admet-2455	122	8	with	with	ADP
admet-2455	122	9	a	a	DET
admet-2455	122	10	calliper	calliper	NOUN
admet-2455	122	11	and	and	CCONJ
admet-2455	122	12	the	the	DET
admet-2455	122	13	tumour	tumour	NOUN
admet-2455	122	14	volumes	volume	NOUN
admet-2455	122	15	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	ADP
admet-2455	122	16	y.	y.	PROPN
admet-2455	122	17	zhou	zhou	PROPN
admet-2455	122	18	et	et	PROPN
admet-2455	122	19	al	al	PROPN
admet-2455	122	20	.	.	PROPN
admet-2455	122	21	admet	admet	PROPN
admet-2455	122	22	&	&	CCONJ
admet-2455	122	23	dmpk	dmpk	PROPN
admet-2455	122	24	12(6	12(6	NUM
admet-2455	122	25	)	)	PUNCT
admet-2455	122	26	(	(	PUNCT
admet-2455	122	27	2024	2024	NUM
admet-2455	122	28	)	)	PUNCT
admet-2455	122	29	821	821	NUM
admet-2455	122	30	-	-	SYM
admet-2455	122	31	841	841	NUM
admet-2455	122	32	826	826	NUM
admet-2455	122	33	were	be	AUX
admet-2455	122	34	calculated	calculate	VERB
admet-2455	122	35	by	by	ADP
admet-2455	122	36	applying	apply	VERB
admet-2455	122	37	the	the	DET
admet-2455	122	38	formula	formula	NOUN
admet-2455	122	39	which	which	PRON
admet-2455	122	40	depicted	depict	VERB
admet-2455	122	41	as	as	ADP
admet-2455	122	42	v	v	NOUN
admet-2455	122	43	=	=	SYM
admet-2455	122	44	(	(	PUNCT
admet-2455	122	45	w2l)/2	w2l)/2	PROPN
admet-2455	122	46	,	,	PUNCT
admet-2455	122	47	where	where	SCONJ
admet-2455	122	48	v	v	NOUN
admet-2455	122	49	is	be	AUX
admet-2455	122	50	tumour	tumour	ADJ
admet-2455	122	51	volume	volume	NOUN
admet-2455	122	52	,	,	PUNCT
admet-2455	122	53	w	w	PROPN
admet-2455	122	54	is	be	AUX
admet-2455	122	55	tumour	tumour	NOUN
admet-2455	122	56	width	width	NOUN
admet-2455	122	57	and	and	CCONJ
admet-2455	122	58	l	l	NOUN
admet-2455	122	59	is	be	AUX
admet-2455	122	60	tumour	tumour	ADJ
admet-2455	122	61	length	length	NOUN
admet-2455	122	62	.	.	PUNCT
admet-2455	123	1	bioinformatics	bioinformatic	NOUN
admet-2455	123	2	analysis	analysis	NOUN
admet-2455	123	3	normalized	normalize	VERB
admet-2455	123	4	hk2	hk2	NOUN
admet-2455	123	5	protein	protein	NOUN
admet-2455	123	6	expression	expression	NOUN
admet-2455	123	7	values	value	NOUN
admet-2455	123	8	were	be	AUX
admet-2455	123	9	downloaded	download	VERB
admet-2455	123	10	from	from	ADP
admet-2455	123	11	the	the	DET
admet-2455	123	12	clinical	clinical	ADJ
admet-2455	123	13	proteomic	proteomic	ADJ
admet-2455	123	14	tumour	tumour	NOUN
admet-2455	123	15	analysis	analysis	NOUN
admet-2455	123	16	consortium	consortium	NOUN
admet-2455	123	17	(	(	PUNCT
admet-2455	123	18	cptac	cptac	NOUN
admet-2455	123	19	)	)	PUNCT
admet-2455	123	20	data	datum	NOUN
admet-2455	123	21	portal	portal	NOUN
admet-2455	123	22	.	.	PUNCT
admet-2455	124	1	pan	pan	NOUN
admet-2455	124	2	-	-	ADJ
admet-2455	124	3	cancer	cancer	ADJ
admet-2455	124	4	molecular	molecular	ADJ
admet-2455	124	5	subtypes	subtype	NOUN
admet-2455	124	6	were	be	AUX
admet-2455	124	7	revealed	reveal	VERB
admet-2455	124	8	by	by	ADP
admet-2455	124	9	mass	mass	ADJ
admet-2455	124	10	-	-	PUNCT
admet-2455	124	11	spectrometry	spectrometry	NOUN
admet-2455	124	12	-	-	PUNCT
admet-2455	124	13	based	base	VERB
admet-2455	124	14	proteomic	proteomic	ADJ
admet-2455	124	15	characterization	characterization	NOUN
admet-2455	124	16	of	of	ADP
admet-2455	124	17	more	more	ADJ
admet-2455	124	18	than	than	ADP
admet-2455	124	19	500	500	NUM
admet-2455	124	20	aggressive	aggressive	ADJ
admet-2455	124	21	human	human	ADJ
admet-2455	124	22	cancers	cancer	NOUN
admet-2455	124	23	.	.	PUNCT
admet-2455	125	1	the	the	DET
admet-2455	125	2	mrna	mrna	PROPN
admet-2455	125	3	expressions	expression	NOUN
admet-2455	125	4	of	of	ADP
admet-2455	125	5	hk2	hk2	PROPN
admet-2455	125	6	were	be	AUX
admet-2455	125	7	obtained	obtain	VERB
admet-2455	125	8	from	from	ADP
admet-2455	125	9	the	the	DET
admet-2455	125	10	r	r	NOUN
admet-2455	125	11	package	package	NOUN
admet-2455	125	12	tcgabiolinks	tcgabiolink	NOUN
admet-2455	125	13	.	.	PUNCT
admet-2455	126	1	tpm	tpm	PROPN
admet-2455	126	2	(	(	PUNCT
admet-2455	126	3	transcripts	transcript	NOUN
admet-2455	126	4	per	per	ADP
admet-2455	126	5	kilobase	kilobase	NOUN
admet-2455	126	6	per	per	ADP
admet-2455	126	7	million	million	NUM
admet-2455	126	8	)	)	PUNCT
admet-2455	126	9	was	be	AUX
admet-2455	126	10	used	use	VERB
admet-2455	126	11	to	to	PART
admet-2455	126	12	quantify	quantify	VERB
admet-2455	126	13	the	the	DET
admet-2455	126	14	mrna	mrna	NOUN
admet-2455	126	15	expression	expression	NOUN
admet-2455	126	16	and	and	CCONJ
admet-2455	126	17	to	to	PART
admet-2455	126	18	compare	compare	VERB
admet-2455	126	19	the	the	DET
admet-2455	126	20	gene	gene	NOUN
admet-2455	126	21	expression	expression	NOUN
admet-2455	126	22	level	level	NOUN
admet-2455	126	23	between	between	ADP
admet-2455	126	24	tumour	tumour	NOUN
admet-2455	126	25	s	s	NOUN
admet-2455	126	26	and	and	CCONJ
admet-2455	126	27	their	their	PRON
admet-2455	126	28	paired	pair	VERB
admet-2455	126	29	normal	normal	ADJ
admet-2455	126	30	tissues	tissue	NOUN
admet-2455	126	31	.	.	PUNCT
admet-2455	127	1	statistical	statistical	ADJ
admet-2455	127	2	analysis	analysis	NOUN
admet-2455	127	3	all	all	DET
admet-2455	127	4	experiments	experiment	NOUN
admet-2455	127	5	were	be	AUX
admet-2455	127	6	independently	independently	ADV
admet-2455	127	7	repeated	repeat	VERB
admet-2455	127	8	at	at	ADP
admet-2455	127	9	least	least	ADV
admet-2455	127	10	three	three	NUM
admet-2455	127	11	times	time	NOUN
admet-2455	127	12	,	,	PUNCT
admet-2455	127	13	except	except	SCONJ
admet-2455	127	14	for	for	ADP
admet-2455	127	15	individual	individual	ADJ
admet-2455	127	16	tumour	tumour	NOUN
admet-2455	127	17	measurements	measurement	NOUN
admet-2455	127	18	.	.	PUNCT
admet-2455	128	1	for	for	SCONJ
admet-2455	128	2	the	the	DET
admet-2455	128	3	statistical	statistical	ADJ
admet-2455	128	4	difference	difference	NOUN
admet-2455	128	5	comparisons	comparison	NOUN
admet-2455	128	6	between	between	ADP
admet-2455	128	7	two	two	NUM
admet-2455	128	8	groups	group	NOUN
admet-2455	128	9	,	,	PUNCT
admet-2455	128	10	two	two	NUM
admet-2455	128	11	-	-	PUNCT
admet-2455	128	12	tailed	tail	VERB
admet-2455	128	13	student	student	NOUN
admet-2455	128	14	’s	’s	PART
admet-2455	128	15	t	t	PROPN
admet-2455	128	16	-	-	PUNCT
admet-2455	128	17	test	test	NOUN
admet-2455	128	18	was	be	AUX
admet-2455	128	19	used	use	VERB
admet-2455	128	20	.	.	PUNCT
admet-2455	129	1	for	for	ADP
admet-2455	129	2	comparisons	comparison	NOUN
admet-2455	129	3	among	among	ADP
admet-2455	129	4	multiple	multiple	ADJ
admet-2455	129	5	groups	group	NOUN
admet-2455	129	6	,	,	PUNCT
admet-2455	129	7	data	datum	NOUN
admet-2455	129	8	were	be	AUX
admet-2455	129	9	analysed	analyse	VERB
admet-2455	129	10	using	use	VERB
admet-2455	129	11	anova	anova	PROPN
admet-2455	129	12	.	.	PUNCT
admet-2455	130	1	statistical	statistical	ADJ
admet-2455	130	2	data	datum	NOUN
admet-2455	130	3	were	be	AUX
admet-2455	130	4	shown	show	VERB
admet-2455	130	5	as	as	ADP
admet-2455	130	6	mean	mean	NOUN
admet-2455	130	7	±	±	NUM
admet-2455	130	8	se	se	X
admet-2455	130	9	(	(	PUNCT
admet-2455	130	10	standard	standard	ADJ
admet-2455	130	11	error	error	NOUN
admet-2455	130	12	)	)	PUNCT
admet-2455	130	13	(	(	PUNCT
admet-2455	130	14	n	n	NOUN
admet-2455	130	15	=	=	SYM
admet-2455	130	16	3	3	NUM
admet-2455	130	17	independent	independent	ADJ
admet-2455	130	18	experiments	experiment	NOUN
admet-2455	130	19	)	)	PUNCT
admet-2455	130	20	.	.	PUNCT
admet-2455	131	1	data	datum	NOUN
admet-2455	131	2	were	be	AUX
admet-2455	131	3	analysed	analyse	VERB
admet-2455	131	4	by	by	ADP
admet-2455	131	5	graphpad	graphpad	NOUN
admet-2455	131	6	prism8	prism8	NOUN
admet-2455	131	7	software	software	NOUN
admet-2455	131	8	and	and	CCONJ
admet-2455	131	9	the	the	DET
admet-2455	131	10	p	p	NOUN
admet-2455	131	11	value	value	NOUN
admet-2455	131	12	less	less	ADJ
admet-2455	131	13	than	than	ADP
admet-2455	131	14	0.05	0.05	NUM
admet-2455	131	15	was	be	AUX
admet-2455	131	16	considered	consider	VERB
admet-2455	131	17	significant	significant	ADJ
admet-2455	131	18	(	(	PUNCT
admet-2455	131	19	ns	ns	ADJ
admet-2455	131	20	indicates	indicate	VERB
admet-2455	131	21	non	non	ADJ
admet-2455	131	22	-	-	ADJ
admet-2455	131	23	significant	significant	ADJ
admet-2455	131	24	,	,	PUNCT
admet-2455	131	25	*	*	PUNCT
admet-2455	131	26	represents	represent	VERB
admet-2455	131	27	p	p	PRON
admet-2455	131	28	<	<	X
admet-2455	131	29	0.05	0.05	NUM
admet-2455	131	30	,	,	PUNCT
admet-2455	131	31	*	*	PUNCT
admet-2455	131	32	*	*	PUNCT
admet-2455	131	33	represents	represent	VERB
admet-2455	131	34	p<0.01	p<0.01	PROPN
admet-2455	131	35	,	,	PUNCT
admet-2455	131	36	*	*	PUNCT
admet-2455	131	37	*	*	PUNCT
admet-2455	131	38	*	*	PUNCT
admet-2455	131	39	represents	represent	VERB
admet-2455	131	40	p<0.001	p<0.001	PROPN
admet-2455	131	41	,	,	PUNCT
admet-2455	131	42	*	*	PUNCT
admet-2455	131	43	*	*	PUNCT
admet-2455	131	44	*	*	PUNCT
admet-2455	131	45	*	*	PUNCT
admet-2455	131	46	represents	represent	VERB
admet-2455	131	47	p	p	PRON
admet-2455	131	48	<	<	X
admet-2455	131	49	0.0001	0.0001	NUM
admet-2455	131	50	)	)	PUNCT
admet-2455	131	51	.	.	PUNCT
admet-2455	132	1	results	result	NOUN
admet-2455	132	2	hk2	hk2	PROPN
admet-2455	132	3	expressions	expression	NOUN
admet-2455	132	4	were	be	AUX
admet-2455	132	5	significantly	significantly	ADV
admet-2455	132	6	enhanced	enhance	VERB
admet-2455	132	7	in	in	ADP
admet-2455	132	8	malignant	malignant	ADJ
admet-2455	132	9	tumour	tumour	NOUN
admet-2455	132	10	s	s	VERB
admet-2455	132	11	a	a	DET
admet-2455	132	12	number	number	NOUN
admet-2455	132	13	of	of	ADP
admet-2455	132	14	tumour	tumour	NOUN
admet-2455	132	15	s	s	NOUN
admet-2455	132	16	with	with	ADP
admet-2455	132	17	high	high	ADJ
admet-2455	132	18	expression	expression	NOUN
admet-2455	132	19	of	of	ADP
admet-2455	132	20	hk2	hk2	PROPN
admet-2455	132	21	have	have	AUX
admet-2455	132	22	been	be	AUX
admet-2455	132	23	associated	associate	VERB
admet-2455	132	24	with	with	ADP
admet-2455	132	25	malignant	malignant	ADJ
admet-2455	132	26	properties	property	NOUN
admet-2455	132	27	[	[	X
admet-2455	132	28	3033	3033	NUM
admet-2455	132	29	]	]	PUNCT
admet-2455	132	30	.	.	PUNCT
admet-2455	133	1	to	to	PART
admet-2455	133	2	gain	gain	VERB
admet-2455	133	3	insights	insight	NOUN
admet-2455	133	4	into	into	ADP
admet-2455	133	5	the	the	DET
admet-2455	133	6	potential	potential	ADJ
admet-2455	133	7	roles	role	NOUN
admet-2455	133	8	of	of	ADP
admet-2455	133	9	hk2	hk2	PROPN
admet-2455	133	10	in	in	ADP
admet-2455	133	11	tumour	tumour	NOUN
admet-2455	133	12	malignancy	malignancy	NOUN
admet-2455	133	13	,	,	PUNCT
admet-2455	133	14	particularly	particularly	ADV
admet-2455	133	15	in	in	ADP
admet-2455	133	16	cervical	cervical	ADJ
admet-2455	133	17	cancer	cancer	NOUN
admet-2455	133	18	and	and	CCONJ
admet-2455	133	19	oral	oral	ADJ
admet-2455	133	20	squamous	squamous	ADJ
admet-2455	133	21	cell	cell	NOUN
admet-2455	133	22	carcinoma	carcinoma	NOUN
admet-2455	133	23	(	(	PUNCT
admet-2455	133	24	oscc	oscc	ADJ
admet-2455	133	25	)	)	PUNCT
admet-2455	133	26	,	,	PUNCT
admet-2455	133	27	databases	database	NOUN
admet-2455	133	28	from	from	ADP
admet-2455	133	29	the	the	DET
admet-2455	133	30	cancer	cancer	NOUN
admet-2455	133	31	genome	genome	NOUN
admet-2455	133	32	atlas	atlas	PROPN
admet-2455	133	33	(	(	PUNCT
admet-2455	133	34	tcga	tcga	PROPN
admet-2455	133	35	)	)	PUNCT
admet-2455	133	36	and	and	CCONJ
admet-2455	133	37	the	the	DET
admet-2455	133	38	national	national	PROPN
admet-2455	133	39	cancer	cancer	PROPN
admet-2455	133	40	institute	institute	PROPN
admet-2455	133	41	’s	’s	PART
admet-2455	133	42	clinical	clinical	ADJ
admet-2455	133	43	proteomic	proteomic	ADJ
admet-2455	133	44	tumour	tumour	NOUN
admet-2455	133	45	analysis	analysis	NOUN
admet-2455	133	46	consortium	consortium	NOUN
admet-2455	133	47	(	(	PUNCT
admet-2455	133	48	cptac	cptac	NOUN
admet-2455	133	49	)	)	PUNCT
admet-2455	133	50	were	be	AUX
admet-2455	133	51	used	use	VERB
admet-2455	133	52	to	to	PART
admet-2455	133	53	analyse	analyse	VERB
admet-2455	133	54	the	the	DET
admet-2455	133	55	transcriptional	transcriptional	ADJ
admet-2455	133	56	expression	expression	NOUN
admet-2455	133	57	and	and	CCONJ
admet-2455	133	58	protein	protein	NOUN
admet-2455	133	59	level	level	NOUN
admet-2455	133	60	of	of	ADP
admet-2455	133	61	hk2	hk2	PROPN
admet-2455	133	62	.	.	PUNCT
admet-2455	133	63	compared	compare	VERB
admet-2455	133	64	with	with	ADP
admet-2455	133	65	adjacent	adjacent	ADJ
admet-2455	133	66	normal	normal	ADJ
admet-2455	133	67	tissues	tissue	NOUN
admet-2455	133	68	,	,	PUNCT
admet-2455	133	69	expressions	expression	NOUN
admet-2455	133	70	of	of	ADP
admet-2455	133	71	hk2	hk2	PROPN
admet-2455	133	72	mrna	mrna	PROPN
admet-2455	133	73	were	be	AUX
admet-2455	133	74	significantly	significantly	ADV
admet-2455	133	75	higher	high	ADJ
admet-2455	133	76	in	in	ADP
admet-2455	133	77	cervical	cervical	ADJ
admet-2455	133	78	cancers	cancer	NOUN
admet-2455	133	79	(	(	PUNCT
admet-2455	133	80	figure	figure	NOUN
admet-2455	133	81	1a	1a	NOUN
admet-2455	133	82	)	)	PUNCT
admet-2455	133	83	.	.	PUNCT
admet-2455	134	1	subsequent	subsequent	ADJ
admet-2455	134	2	kaplan	kaplan	PROPN
admet-2455	134	3	-	-	PUNCT
admet-2455	134	4	meier	meier	PROPN
admet-2455	134	5	survival	survival	NOUN
admet-2455	134	6	analysis	analysis	NOUN
admet-2455	134	7	showed	show	VERB
admet-2455	134	8	that	that	SCONJ
admet-2455	134	9	hk2	hk2	PROPN
admet-2455	134	10	expression	expression	NOUN
admet-2455	134	11	was	be	AUX
admet-2455	134	12	negatively	negatively	ADV
admet-2455	134	13	correlated	correlate	VERB
admet-2455	134	14	with	with	ADP
admet-2455	134	15	the	the	DET
admet-2455	134	16	overall	overall	ADJ
admet-2455	134	17	survival	survival	NOUN
admet-2455	134	18	probability	probability	NOUN
admet-2455	134	19	of	of	ADP
admet-2455	134	20	patient	patient	NOUN
admet-2455	134	21	with	with	ADP
admet-2455	134	22	cervical	cervical	ADJ
admet-2455	134	23	carcinoma	carcinoma	NOUN
admet-2455	134	24	(	(	PUNCT
admet-2455	134	25	figure	figure	NOUN
admet-2455	134	26	1b	1b	NUM
admet-2455	134	27	)	)	PUNCT
admet-2455	134	28	.	.	PUNCT
admet-2455	135	1	unfortunately	unfortunately	ADV
admet-2455	135	2	,	,	PUNCT
admet-2455	135	3	there	there	PRON
admet-2455	135	4	is	be	VERB
admet-2455	135	5	a	a	DET
admet-2455	135	6	scarcity	scarcity	NOUN
admet-2455	135	7	of	of	ADP
admet-2455	135	8	data	datum	NOUN
admet-2455	135	9	specifically	specifically	ADV
admet-2455	135	10	on	on	ADP
admet-2455	135	11	oral	oral	ADJ
admet-2455	135	12	squamous	squamous	ADJ
admet-2455	135	13	cell	cell	NOUN
admet-2455	135	14	carcinoma	carcinoma	NOUN
admet-2455	135	15	(	(	PUNCT
admet-2455	135	16	oscc	oscc	ADJ
admet-2455	135	17	)	)	PUNCT
admet-2455	135	18	.	.	PUNCT
admet-2455	136	1	nevertheless	nevertheless	ADV
admet-2455	136	2	,	,	PUNCT
admet-2455	136	3	we	we	PRON
admet-2455	136	4	investigated	investigate	VERB
admet-2455	136	5	head	head	NOUN
admet-2455	136	6	and	and	CCONJ
admet-2455	136	7	neck	neck	VERB
admet-2455	136	8	squamous	squamous	ADJ
admet-2455	136	9	cell	cell	NOUN
admet-2455	136	10	carcinoma	carcinoma	NOUN
admet-2455	136	11	(	(	PUNCT
admet-2455	136	12	hnscc	hnscc	NOUN
admet-2455	136	13	)	)	PUNCT
admet-2455	136	14	,	,	PUNCT
admet-2455	136	15	which	which	PRON
admet-2455	136	16	is	be	AUX
admet-2455	136	17	a	a	DET
admet-2455	136	18	broader	broad	ADJ
admet-2455	136	19	term	term	NOUN
admet-2455	136	20	that	that	PRON
admet-2455	136	21	covers	cover	VERB
admet-2455	136	22	squamous	squamous	ADJ
admet-2455	136	23	cell	cell	NOUN
admet-2455	136	24	carcinomas	carcinoma	NOUN
admet-2455	136	25	from	from	ADP
admet-2455	136	26	different	different	ADJ
admet-2455	136	27	parts	part	NOUN
admet-2455	136	28	of	of	ADP
admet-2455	136	29	the	the	DET
admet-2455	136	30	head	head	NOUN
admet-2455	136	31	and	and	CCONJ
admet-2455	136	32	neck	neck	NOUN
admet-2455	136	33	area	area	NOUN
admet-2455	136	34	,	,	PUNCT
admet-2455	136	35	including	include	VERB
admet-2455	136	36	the	the	DET
admet-2455	136	37	oral	oral	ADJ
admet-2455	136	38	cavity	cavity	NOUN
admet-2455	136	39	.	.	PUNCT
admet-2455	137	1	both	both	PRON
admet-2455	137	2	mrna	mrna	NOUN
admet-2455	137	3	and	and	CCONJ
admet-2455	137	4	protein	protein	NOUN
admet-2455	137	5	expression	expression	NOUN
admet-2455	137	6	levels	level	NOUN
admet-2455	137	7	were	be	AUX
admet-2455	137	8	pronounced	pronounce	VERB
admet-2455	137	9	higher	higher	ADV
admet-2455	137	10	in	in	ADP
admet-2455	137	11	hnsccs	hnsccs	NOUN
admet-2455	137	12	than	than	SCONJ
admet-2455	137	13	normal	normal	ADJ
admet-2455	137	14	tissues	tissue	NOUN
admet-2455	137	15	(	(	PUNCT
admet-2455	137	16	figures	figure	NOUN
admet-2455	137	17	1c	1c	NOUN
admet-2455	137	18	and	and	CCONJ
admet-2455	137	19	1d	1d	NUM
admet-2455	137	20	)	)	PUNCT
admet-2455	137	21	.	.	PUNCT
admet-2455	138	1	moreover	moreover	ADV
admet-2455	138	2	,	,	PUNCT
admet-2455	138	3	the	the	DET
admet-2455	138	4	enhanced	enhance	VERB
admet-2455	138	5	hk2	hk2	NOUN
admet-2455	138	6	protein	protein	NOUN
admet-2455	138	7	expressions	expression	NOUN
admet-2455	138	8	on	on	ADP
admet-2455	138	9	hela	hela	PROPN
admet-2455	138	10	and	and	CCONJ
admet-2455	138	11	scc25	scc25	PROPN
admet-2455	138	12	cell	cell	NOUN
admet-2455	138	13	lines	line	NOUN
admet-2455	138	14	compared	compare	VERB
admet-2455	138	15	to	to	ADP
admet-2455	138	16	normal	normal	ADJ
admet-2455	138	17	human	human	ADJ
admet-2455	138	18	fibroblast	fibroblast	ADJ
admet-2455	138	19	cells	cell	NOUN
admet-2455	138	20	were	be	AUX
admet-2455	138	21	validated	validate	VERB
admet-2455	138	22	via	via	ADP
admet-2455	138	23	western	western	ADJ
admet-2455	138	24	blotting	blotting	NOUN
admet-2455	138	25	(	(	PUNCT
admet-2455	138	26	figures	figure	NOUN
admet-2455	138	27	1e	1e	NOUN
admet-2455	138	28	and	and	CCONJ
admet-2455	138	29	1f	1f	NUM
admet-2455	138	30	)	)	PUNCT
admet-2455	138	31	.	.	PUNCT
admet-2455	139	1	in	in	ADP
admet-2455	139	2	addition	addition	NOUN
admet-2455	139	3	,	,	PUNCT
admet-2455	139	4	6	6	NUM
admet-2455	139	5	h	h	NOUN
admet-2455	139	6	tcs	tcs	NOUN
admet-2455	139	7	treatments	treatment	NOUN
admet-2455	139	8	significantly	significantly	ADV
admet-2455	139	9	facilitated	facilitate	VERB
admet-2455	139	10	hexokinase	hexokinase	NOUN
admet-2455	139	11	activities	activity	NOUN
admet-2455	139	12	in	in	ADP
admet-2455	139	13	both	both	CCONJ
admet-2455	139	14	hela	hela	PROPN
admet-2455	139	15	and	and	CCONJ
admet-2455	139	16	scc25	scc25	PROPN
admet-2455	139	17	cells	cell	NOUN
admet-2455	139	18	,	,	PUNCT
admet-2455	139	19	indicating	indicate	VERB
admet-2455	139	20	tcs	tcs	NOUN
admet-2455	139	21	single	single	ADJ
admet-2455	139	22	treatment	treatment	NOUN
admet-2455	139	23	enhanced	enhance	VERB
admet-2455	139	24	hk2	hk2	NOUN
admet-2455	139	25	activities	activity	NOUN
admet-2455	139	26	(	(	PUNCT
admet-2455	139	27	figure	figure	NOUN
admet-2455	139	28	1	1	NUM
admet-2455	139	29	g	g	NOUN
admet-2455	139	30	)	)	PUNCT
admet-2455	139	31	.	.	PUNCT
admet-2455	140	1	with	with	ADP
admet-2455	140	2	these	these	PRON
admet-2455	140	3	in	in	ADP
admet-2455	140	4	mind	mind	NOUN
admet-2455	140	5	,	,	PUNCT
admet-2455	140	6	the	the	DET
admet-2455	140	7	hk2	hk2	PROPN
admet-2455	140	8	inhibitor	inhibitor	PROPN
admet-2455	140	9	benz	benz	PROPN
admet-2455	140	10	(	(	PUNCT
admet-2455	140	11	figure	figure	NOUN
admet-2455	140	12	1h	1h	NUM
admet-2455	140	13	)	)	PUNCT
admet-2455	140	14	was	be	AUX
admet-2455	140	15	used	use	VERB
admet-2455	140	16	in	in	ADP
admet-2455	140	17	combination	combination	NOUN
admet-2455	140	18	with	with	ADP
admet-2455	140	19	tcs	tcs	NOUN
admet-2455	140	20	to	to	PART
admet-2455	140	21	evaluate	evaluate	VERB
admet-2455	140	22	the	the	DET
admet-2455	140	23	anticancer	anticancer	NOUN
admet-2455	140	24	effects	effect	NOUN
admet-2455	140	25	in	in	ADP
admet-2455	140	26	hela	hela	PROPN
admet-2455	140	27	and	and	CCONJ
admet-2455	140	28	scc25	scc25	PROPN
admet-2455	140	29	cell	cell	NOUN
admet-2455	140	30	models	model	NOUN
admet-2455	140	31	.	.	PUNCT
admet-2455	141	1	admet	admet	PROPN
admet-2455	141	2	&	&	CCONJ
admet-2455	141	3	dmpk	dmpk	PROPN
admet-2455	141	4	12(6	12(6	NUM
admet-2455	141	5	)	)	PUNCT
admet-2455	141	6	(	(	PUNCT
admet-2455	141	7	2024	2024	NUM
admet-2455	141	8	)	)	PUNCT
admet-2455	141	9	821	821	NUM
admet-2455	141	10	-	-	SYM
admet-2455	141	11	841	841	NUM
admet-2455	141	12	targeting	targeting	NOUN
admet-2455	141	13	hexokinase	hexokinase	NOUN
admet-2455	141	14	2	2	NUM
admet-2455	141	15	to	to	PART
admet-2455	141	16	enhance	enhance	VERB
admet-2455	141	17	anticancer	anticancer	NOUN
admet-2455	141	18	efficacy	efficacy	NOUN
admet-2455	141	19	of	of	ADP
admet-2455	141	20	trichosanthin	trichosanthin	PROPN
admet-2455	141	21	doi	doi	PROPN
admet-2455	141	22	:	:	PUNCT
admet-2455	141	23	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PRON
admet-2455	141	24	827	827	NUM
admet-2455	141	25	figure	figure	NOUN
admet-2455	141	26	1	1	NUM
admet-2455	141	27	.	.	PUNCT
admet-2455	141	28	investigation	investigation	NOUN
admet-2455	141	29	of	of	ADP
admet-2455	141	30	hk2	hk2	NOUN
admet-2455	141	31	expression	expression	NOUN
admet-2455	141	32	and	and	CCONJ
admet-2455	141	33	its	its	PRON
admet-2455	141	34	potential	potential	ADJ
admet-2455	141	35	clinical	clinical	ADJ
admet-2455	141	36	significance	significance	NOUN
admet-2455	141	37	in	in	ADP
admet-2455	141	38	malignant	malignant	ADJ
admet-2455	141	39	tumour	tumour	NOUN
admet-2455	141	40	s.	s.	PROPN
admet-2455	141	41	(	(	PUNCT
admet-2455	141	42	a	a	X
admet-2455	141	43	)	)	PUNCT
admet-2455	141	44	the	the	DET
admet-2455	141	45	relative	relative	ADJ
admet-2455	141	46	mrna	mrna	PROPN
admet-2455	141	47	expressions	expression	NOUN
admet-2455	141	48	of	of	ADP
admet-2455	141	49	hk2	hk2	PROPN
admet-2455	141	50	in	in	ADP
admet-2455	141	51	cervical	cervical	ADJ
admet-2455	141	52	carcinoma	carcinoma	NOUN
admet-2455	141	53	tissues	tissue	NOUN
admet-2455	141	54	and	and	CCONJ
admet-2455	141	55	adjacent	adjacent	ADJ
admet-2455	141	56	normal	normal	ADJ
admet-2455	141	57	tissues	tissue	NOUN
admet-2455	141	58	.	.	PUNCT
admet-2455	142	1	(	(	PUNCT
admet-2455	142	2	b	b	X
admet-2455	142	3	)	)	PUNCT
admet-2455	142	4	kaplan	kaplan	PROPN
admet-2455	142	5	–	–	PUNCT
admet-2455	142	6	meier	meier	PROPN
admet-2455	142	7	survival	survival	NOUN
admet-2455	142	8	curves	curve	NOUN
admet-2455	142	9	of	of	ADP
admet-2455	142	10	patients	patient	NOUN
admet-2455	142	11	with	with	ADP
admet-2455	142	12	cervical	cervical	ADJ
admet-2455	142	13	cancer	cancer	NOUN
admet-2455	142	14	stratified	stratify	VERB
admet-2455	142	15	by	by	ADP
admet-2455	142	16	high	high	ADJ
admet-2455	142	17	and	and	CCONJ
admet-2455	142	18	low	low	ADJ
admet-2455	142	19	hk2	hk2	NOUN
admet-2455	142	20	transcription	transcription	NOUN
admet-2455	142	21	expression	expression	NOUN
admet-2455	142	22	levels	level	NOUN
admet-2455	142	23	(	(	PUNCT
admet-2455	142	24	p	p	X
admet-2455	142	25	 	 	SPACE
admet-2455	142	26	<	<	X
admet-2455	142	27	 	 	SPACE
admet-2455	142	28	0.05	0.05	NUM
admet-2455	142	29	)	)	PUNCT
admet-2455	142	30	.	.	PUNCT
admet-2455	143	1	(	(	PUNCT
admet-2455	143	2	c	c	X
admet-2455	143	3	,	,	PUNCT
admet-2455	143	4	d	d	NOUN
admet-2455	143	5	)	)	PUNCT
admet-2455	143	6	the	the	DET
admet-2455	143	7	relative	relative	ADJ
admet-2455	143	8	mrna	mrna	NOUN
admet-2455	143	9	and	and	CCONJ
admet-2455	143	10	protein	protein	NOUN
admet-2455	143	11	expression	expression	NOUN
admet-2455	143	12	levels	level	NOUN
admet-2455	143	13	of	of	ADP
admet-2455	143	14	hk2	hk2	PROPN
admet-2455	143	15	in	in	ADP
admet-2455	143	16	hnscc	hnscc	NOUN
admet-2455	143	17	tissues	tissue	NOUN
admet-2455	143	18	and	and	CCONJ
admet-2455	143	19	adjacent	adjacent	ADJ
admet-2455	143	20	normal	normal	ADJ
admet-2455	143	21	tissues	tissue	NOUN
admet-2455	143	22	.	.	PUNCT
admet-2455	144	1	(	(	PUNCT
admet-2455	144	2	e	e	NOUN
admet-2455	144	3	)	)	PUNCT
admet-2455	144	4	western	western	ADJ
admet-2455	144	5	blot	blot	NOUN
admet-2455	144	6	detection	detection	NOUN
admet-2455	144	7	of	of	ADP
admet-2455	144	8	hk2	hk2	NOUN
admet-2455	144	9	protein	protein	NOUN
admet-2455	144	10	expression	expression	NOUN
admet-2455	144	11	on	on	ADP
admet-2455	144	12	three	three	NUM
admet-2455	144	13	cell	cell	NOUN
admet-2455	144	14	lines	line	NOUN
admet-2455	144	15	,	,	PUNCT
admet-2455	144	16	including	include	VERB
admet-2455	144	17	normal	normal	ADJ
admet-2455	144	18	fibroblast	fibroblast	ADJ
admet-2455	144	19	,	,	PUNCT
admet-2455	144	20	scc25	scc25	NOUN
admet-2455	144	21	,	,	PUNCT
admet-2455	144	22	and	and	CCONJ
admet-2455	144	23	hela	hela	ADJ
admet-2455	144	24	.	.	PUNCT
admet-2455	145	1	(	(	PUNCT
admet-2455	145	2	f	f	X
admet-2455	145	3	)	)	PUNCT
admet-2455	145	4	quantified	quantified	ADJ
admet-2455	145	5	data	datum	NOUN
admet-2455	145	6	were	be	AUX
admet-2455	145	7	presented	present	VERB
admet-2455	145	8	as	as	ADP
admet-2455	145	9	mean	mean	NOUN
admet-2455	145	10	±	±	NUM
admet-2455	145	11	se	se	X
admet-2455	145	12	(	(	PUNCT
admet-2455	145	13	n	n	NOUN
admet-2455	145	14	=	=	SYM
admet-2455	145	15	3	3	NUM
admet-2455	145	16	)	)	PUNCT
admet-2455	145	17	.	.	PUNCT
admet-2455	146	1	(	(	PUNCT
admet-2455	146	2	g	g	NOUN
admet-2455	146	3	)	)	PUNCT
admet-2455	146	4	the	the	DET
admet-2455	146	5	hexokinase	hexokinase	NOUN
admet-2455	146	6	activities	activity	NOUN
admet-2455	146	7	in	in	ADP
admet-2455	146	8	hela	hela	PROPN
admet-2455	146	9	and	and	CCONJ
admet-2455	146	10	scc25	scc25	PROPN
admet-2455	146	11	cells	cell	NOUN
admet-2455	146	12	under	under	ADP
admet-2455	146	13	25	25	NUM
admet-2455	146	14	and	and	CCONJ
admet-2455	146	15	50	50	NUM
admet-2455	146	16	μg	μg	NOUN
admet-2455	146	17	/	/	SYM
admet-2455	146	18	ml	ml	PROPN
admet-2455	146	19	tcs	tcs	NOUN
admet-2455	146	20	treatments	treatment	NOUN
admet-2455	146	21	.	.	PUNCT
admet-2455	147	1	(	(	PUNCT
admet-2455	147	2	h	h	NOUN
admet-2455	147	3	)	)	PUNCT
admet-2455	147	4	chemical	chemical	NOUN
admet-2455	147	5	structure	structure	NOUN
admet-2455	147	6	of	of	ADP
admet-2455	147	7	hk2	hk2	PROPN
admet-2455	147	8	inhibitor	inhibitor	NOUN
admet-2455	147	9	,	,	PUNCT
admet-2455	147	10	benserazide	benserazide	ADJ
admet-2455	147	11	hydrochloride	hydrochloride	NOUN
admet-2455	147	12	.	.	PUNCT
admet-2455	148	1	*	*	PUNCT
admet-2455	148	2	*	*	PUNCT
admet-2455	148	3	represents	represent	VERB
admet-2455	148	4	p<0.01	p<0.01	PROPN
admet-2455	148	5	,	,	PUNCT
admet-2455	148	6	*	*	PUNCT
admet-2455	148	7	*	*	PUNCT
admet-2455	148	8	*	*	PUNCT
admet-2455	148	9	*	*	PUNCT
admet-2455	148	10	represents	represent	VERB
admet-2455	148	11	p	p	PRON
admet-2455	148	12	<	<	X
admet-2455	148	13	0.0001	0.0001	NUM
admet-2455	148	14	.	.	PUNCT
admet-2455	149	1	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PROPN
admet-2455	149	2	y.	y.	PROPN
admet-2455	149	3	zhou	zhou	PROPN
admet-2455	149	4	et	et	PROPN
admet-2455	149	5	al	al	PROPN
admet-2455	149	6	.	.	PROPN
admet-2455	149	7	admet	admet	PROPN
admet-2455	149	8	&	&	CCONJ
admet-2455	149	9	dmpk	dmpk	PROPN
admet-2455	149	10	12(6	12(6	NUM
admet-2455	149	11	)	)	PUNCT
admet-2455	149	12	(	(	PUNCT
admet-2455	149	13	2024	2024	NUM
admet-2455	149	14	)	)	PUNCT
admet-2455	149	15	821	821	NUM
admet-2455	149	16	-	-	SYM
admet-2455	149	17	841	841	NUM
admet-2455	149	18	828	828	NUM
admet-2455	149	19	combined	combine	VERB
admet-2455	149	20	use	use	NOUN
admet-2455	149	21	of	of	ADP
admet-2455	149	22	tcs	tcs	NOUN
admet-2455	149	23	and	and	CCONJ
admet-2455	149	24	benz	benz	PROPN
admet-2455	149	25	demonstrated	demonstrate	VERB
admet-2455	149	26	strong	strong	ADJ
admet-2455	149	27	anticancer	anticancer	NOUN
admet-2455	149	28	synergism	synergism	NOUN
admet-2455	149	29	in	in	ADP
admet-2455	149	30	hela	hela	PROPN
admet-2455	149	31	and	and	CCONJ
admet-2455	149	32	scc25	scc25	PROPN
admet-2455	149	33	cells	cell	NOUN
admet-2455	149	34	the	the	DET
admet-2455	149	35	ic50	ic50	PROPN
admet-2455	149	36	values	value	NOUN
admet-2455	149	37	of	of	ADP
admet-2455	149	38	tcs	tcs	NOUN
admet-2455	149	39	and	and	CCONJ
admet-2455	149	40	benz	benz	PROPN
admet-2455	149	41	in	in	ADP
admet-2455	149	42	hela	hela	PROPN
admet-2455	149	43	and	and	CCONJ
admet-2455	149	44	scc25	scc25	PROPN
admet-2455	149	45	cells	cell	NOUN
admet-2455	149	46	under	under	ADP
admet-2455	149	47	72	72	NUM
admet-2455	149	48	h	h	NOUN
admet-2455	149	49	treatments	treatment	NOUN
admet-2455	149	50	were	be	AUX
admet-2455	149	51	determined	determine	VERB
admet-2455	149	52	by	by	ADP
admet-2455	149	53	mtt	mtt	NOUN
admet-2455	149	54	assays	assay	NOUN
admet-2455	149	55	(	(	PUNCT
admet-2455	149	56	table	table	NOUN
admet-2455	149	57	1	1	NUM
admet-2455	149	58	)	)	PUNCT
admet-2455	149	59	.	.	PUNCT
admet-2455	150	1	to	to	PART
admet-2455	150	2	examine	examine	VERB
admet-2455	150	3	the	the	DET
admet-2455	150	4	drug	drug	NOUN
admet-2455	150	5	synergy	synergy	NOUN
admet-2455	150	6	,	,	PUNCT
admet-2455	150	7	hela	hela	PROPN
admet-2455	150	8	cells	cell	NOUN
admet-2455	150	9	were	be	AUX
admet-2455	150	10	treated	treat	VERB
admet-2455	150	11	with	with	ADP
admet-2455	150	12	different	different	ADJ
admet-2455	150	13	concentrations	concentration	NOUN
admet-2455	150	14	of	of	ADP
admet-2455	150	15	tcs	tcs	PROPN
admet-2455	150	16	and	and	CCONJ
admet-2455	150	17	benz	benz	PROPN
admet-2455	150	18	,	,	PUNCT
admet-2455	150	19	either	either	CCONJ
admet-2455	150	20	alone	alone	ADJ
admet-2455	150	21	or	or	CCONJ
admet-2455	150	22	in	in	ADP
admet-2455	150	23	combination	combination	NOUN
admet-2455	150	24	,	,	PUNCT
admet-2455	150	25	for	for	ADP
admet-2455	150	26	72	72	NUM
admet-2455	150	27	h	h	NOUN
admet-2455	150	28	,	,	PUNCT
admet-2455	150	29	followed	follow	VERB
admet-2455	150	30	by	by	ADP
admet-2455	150	31	mtt	mtt	NOUN
admet-2455	150	32	assay	assay	NOUN
admet-2455	150	33	.	.	PUNCT
admet-2455	151	1	compared	compare	VERB
admet-2455	151	2	with	with	ADP
admet-2455	151	3	each	each	DET
admet-2455	151	4	single	single	ADJ
admet-2455	151	5	compound	compound	NOUN
admet-2455	151	6	treatment	treatment	NOUN
admet-2455	151	7	,	,	PUNCT
admet-2455	151	8	the	the	DET
admet-2455	151	9	combo	combo	NOUN
admet-2455	151	10	significantly	significantly	ADV
admet-2455	151	11	inhibited	inhibit	VERB
admet-2455	151	12	cell	cell	NOUN
admet-2455	151	13	survival	survival	NOUN
admet-2455	151	14	rate	rate	NOUN
admet-2455	151	15	(	(	PUNCT
admet-2455	151	16	figure	figure	NOUN
admet-2455	151	17	2a	2a	NUM
admet-2455	151	18	)	)	PUNCT
admet-2455	151	19	.	.	PUNCT
admet-2455	152	1	combination	combination	NOUN
admet-2455	152	2	index	index	NOUN
admet-2455	152	3	(	(	PUNCT
admet-2455	152	4	ci	ci	NOUN
admet-2455	152	5	)	)	PUNCT
admet-2455	152	6	described	describe	VERB
admet-2455	152	7	by	by	ADP
admet-2455	152	8	chou	chou	PROPN
admet-2455	152	9	&	&	CCONJ
admet-2455	152	10	talalay	talalay	PROPN
admet-2455	153	1	[	[	X
admet-2455	153	2	27	27	NUM
admet-2455	153	3	]	]	PUNCT
admet-2455	153	4	was	be	AUX
admet-2455	153	5	then	then	ADV
admet-2455	153	6	employed	employ	VERB
admet-2455	153	7	to	to	PART
admet-2455	153	8	analyse	analyse	VERB
admet-2455	153	9	drug	drug	NOUN
admet-2455	153	10	synergism	synergism	NOUN
admet-2455	153	11	.	.	PUNCT
admet-2455	154	1	each	each	DET
admet-2455	154	2	combined	combined	ADJ
admet-2455	154	3	treatment	treatment	NOUN
admet-2455	154	4	of	of	ADP
admet-2455	154	5	tcs	tcs	NOUN
admet-2455	154	6	and	and	CCONJ
admet-2455	154	7	benz	benz	PROPN
admet-2455	154	8	demonstrated	demonstrate	VERB
admet-2455	154	9	a	a	DET
admet-2455	154	10	strong	strong	ADJ
admet-2455	154	11	synergistic	synergistic	ADJ
admet-2455	154	12	effect	effect	NOUN
admet-2455	154	13	with	with	ADP
admet-2455	154	14	potent	potent	ADJ
admet-2455	154	15	anticancer	anticancer	NOUN
admet-2455	154	16	efficacy	efficacy	NOUN
admet-2455	154	17	in	in	ADP
admet-2455	154	18	hela	hela	ADJ
admet-2455	154	19	cells	cell	NOUN
admet-2455	154	20	,	,	PUNCT
admet-2455	154	21	indicated	indicate	VERB
admet-2455	154	22	by	by	ADP
admet-2455	154	23	ci	ci	NOUN
admet-2455	154	24	values	value	NOUN
admet-2455	154	25	less	less	ADJ
admet-2455	154	26	than	than	ADP
admet-2455	154	27	1	1	NUM
admet-2455	154	28	while	while	SCONJ
admet-2455	154	29	fraction	fraction	NOUN
admet-2455	154	30	affected	affect	VERB
admet-2455	154	31	(	(	PUNCT
admet-2455	154	32	fa	fa	NOUN
admet-2455	154	33	)	)	PUNCT
admet-2455	154	34	values	value	NOUN
admet-2455	154	35	achieved	achieve	VERB
admet-2455	154	36	more	more	ADJ
admet-2455	154	37	than	than	ADP
admet-2455	154	38	0.5	0.5	NUM
admet-2455	154	39	as	as	SCONJ
admet-2455	154	40	shown	show	VERB
admet-2455	154	41	in	in	ADP
admet-2455	154	42	figure	figure	NOUN
admet-2455	154	43	2b	2b	NOUN
admet-2455	154	44	and	and	CCONJ
admet-2455	154	45	table	table	NOUN
admet-2455	154	46	2	2	NUM
admet-2455	154	47	.	.	PUNCT
admet-2455	155	1	consistently	consistently	ADV
admet-2455	155	2	,	,	PUNCT
admet-2455	155	3	similar	similar	ADJ
admet-2455	155	4	results	result	NOUN
admet-2455	155	5	were	be	AUX
admet-2455	155	6	obtained	obtain	VERB
admet-2455	155	7	in	in	ADP
admet-2455	155	8	scc25	scc25	PROPN
admet-2455	155	9	cell	cell	NOUN
admet-2455	155	10	model	model	NOUN
admet-2455	155	11	(	(	PUNCT
admet-2455	155	12	figures	figure	NOUN
admet-2455	155	13	2c	2c	NOUN
admet-2455	155	14	and	and	CCONJ
admet-2455	155	15	2d	2d	NOUN
admet-2455	155	16	,	,	PUNCT
admet-2455	155	17	and	and	CCONJ
admet-2455	155	18	table	table	NOUN
admet-2455	155	19	3	3	NUM
admet-2455	155	20	)	)	PUNCT
admet-2455	155	21	.	.	PUNCT
admet-2455	156	1	besides	besides	ADV
admet-2455	156	2	,	,	PUNCT
admet-2455	156	3	each	each	DET
admet-2455	156	4	combination	combination	NOUN
admet-2455	156	5	exhibited	exhibit	VERB
admet-2455	156	6	pronounced	pronounce	VERB
admet-2455	156	7	cell	cell	NOUN
admet-2455	156	8	viability	viability	NOUN
admet-2455	156	9	inhibition	inhibition	NOUN
admet-2455	156	10	in	in	ADP
admet-2455	156	11	hela	hela	PROPN
admet-2455	156	12	and	and	CCONJ
admet-2455	156	13	scc25	scc25	PROPN
admet-2455	156	14	cells	cell	NOUN
admet-2455	156	15	with	with	ADP
admet-2455	156	16	only	only	ADV
admet-2455	156	17	relatively	relatively	ADV
admet-2455	156	18	mild	mild	ADJ
admet-2455	156	19	effects	effect	NOUN
admet-2455	156	20	in	in	ADP
admet-2455	156	21	human	human	ADJ
admet-2455	156	22	normal	normal	ADJ
admet-2455	156	23	fibroblasts	fibroblast	NOUN
admet-2455	156	24	(	(	PUNCT
admet-2455	156	25	figure	figure	NOUN
admet-2455	156	26	2e	2e	NUM
admet-2455	156	27	)	)	PUNCT
admet-2455	156	28	.	.	PUNCT
admet-2455	157	1	figure	figure	NOUN
admet-2455	157	2	2	2	NUM
admet-2455	157	3	.	.	PUNCT
admet-2455	157	4	drug	drug	NOUN
admet-2455	157	5	synergy	synergy	NOUN
admet-2455	157	6	of	of	ADP
admet-2455	157	7	tcs	tcs	PROPN
admet-2455	157	8	and	and	CCONJ
admet-2455	157	9	benz	benz	PROPN
admet-2455	157	10	combination	combination	NOUN
admet-2455	157	11	in	in	ADP
admet-2455	157	12	hela	hela	PROPN
admet-2455	157	13	and	and	CCONJ
admet-2455	157	14	scc25	scc25	PROPN
admet-2455	157	15	cells	cell	NOUN
admet-2455	157	16	.	.	PUNCT
admet-2455	158	1	(	(	PUNCT
admet-2455	158	2	a	a	X
admet-2455	158	3	)	)	PUNCT
admet-2455	158	4	hela	hela	PROPN
admet-2455	158	5	cell	cell	NOUN
admet-2455	158	6	viability	viability	NOUN
admet-2455	158	7	results	result	NOUN
admet-2455	158	8	after	after	ADP
admet-2455	158	9	72	72	NUM
admet-2455	158	10	h	h	NOUN
admet-2455	158	11	treatments	treatment	NOUN
admet-2455	158	12	of	of	ADP
admet-2455	158	13	tcs	tcs	NOUN
admet-2455	158	14	or	or	CCONJ
admet-2455	158	15	benz	benz	PROPN
admet-2455	158	16	alone	alone	ADV
admet-2455	158	17	and	and	CCONJ
admet-2455	158	18	in	in	ADP
admet-2455	158	19	combination	combination	NOUN
admet-2455	158	20	.	.	PUNCT
admet-2455	159	1	(	(	PUNCT
admet-2455	159	2	b	b	X
admet-2455	159	3	)	)	PUNCT
admet-2455	159	4	plots	plot	NOUN
admet-2455	159	5	of	of	ADP
admet-2455	159	6	ci	ci	NOUN
admet-2455	159	7	values	value	NOUN
admet-2455	159	8	for	for	ADP
admet-2455	159	9	combined	combined	ADJ
admet-2455	159	10	treatments	treatment	NOUN
admet-2455	159	11	of	of	ADP
admet-2455	159	12	tcs	tcs	PROPN
admet-2455	159	13	and	and	CCONJ
admet-2455	159	14	benz	benz	PROPN
admet-2455	159	15	at	at	ADP
admet-2455	159	16	different	different	ADJ
admet-2455	159	17	concentrations	concentration	NOUN
admet-2455	159	18	in	in	ADP
admet-2455	159	19	hela	hela	ADJ
admet-2455	159	20	cells	cell	NOUN
admet-2455	159	21	.	.	PUNCT
admet-2455	160	1	ci	ci	NOUN
admet-2455	160	2	values	value	NOUN
admet-2455	160	3	<	<	X
admet-2455	160	4	0.9	0.9	NUM
admet-2455	160	5	,	,	PUNCT
admet-2455	160	6	0.9	0.9	NUM
admet-2455	160	7	<	<	X
admet-2455	160	8	ci	ci	NOUN
admet-2455	160	9	<	<	X
admet-2455	160	10	1.1	1.1	NUM
admet-2455	160	11	or	or	CCONJ
admet-2455	160	12	>	>	SYM
admet-2455	160	13	1.1	1.1	NUM
admet-2455	160	14	indicates	indicate	VERB
admet-2455	160	15	drug	drug	NOUN
admet-2455	160	16	synergism	synergism	NOUN
admet-2455	160	17	,	,	PUNCT
admet-2455	160	18	additive	additive	NOUN
admet-2455	160	19	,	,	PUNCT
admet-2455	160	20	or	or	CCONJ
admet-2455	160	21	antagonism	antagonism	NOUN
admet-2455	160	22	,	,	PUNCT
admet-2455	160	23	respectively	respectively	ADV
admet-2455	160	24	.	.	PUNCT
admet-2455	161	1	(	(	PUNCT
admet-2455	161	2	c	c	X
admet-2455	161	3	)	)	PUNCT
admet-2455	161	4	cell	cell	NOUN
admet-2455	161	5	viability	viability	NOUN
admet-2455	161	6	inhibition	inhibition	NOUN
admet-2455	161	7	in	in	ADP
admet-2455	161	8	scc25	scc25	ADJ
admet-2455	161	9	cells	cell	NOUN
admet-2455	161	10	under	under	ADP
admet-2455	161	11	72	72	NUM
admet-2455	161	12	h	h	NOUN
admet-2455	161	13	treatments	treatment	NOUN
admet-2455	161	14	.	.	PUNCT
admet-2455	162	1	(	(	PUNCT
admet-2455	162	2	d	d	X
admet-2455	162	3	)	)	PUNCT
admet-2455	162	4	fa	fa	NOUN
admet-2455	162	5	-	-	PUNCT
admet-2455	162	6	ci	ci	NOUN
admet-2455	162	7	plots	plot	NOUN
admet-2455	162	8	in	in	ADP
admet-2455	162	9	scc25	scc25	ADJ
admet-2455	162	10	cells	cell	NOUN
admet-2455	162	11	.	.	PUNCT
admet-2455	163	1	(	(	PUNCT
admet-2455	163	2	e	e	X
admet-2455	163	3	)	)	PUNCT
admet-2455	163	4	evaluating	evaluate	VERB
admet-2455	163	5	the	the	DET
admet-2455	163	6	cell	cell	NOUN
admet-2455	163	7	growth	growth	NOUN
admet-2455	163	8	inhibition	inhibition	NOUN
admet-2455	163	9	of	of	ADP
admet-2455	163	10	combined	combined	ADJ
admet-2455	163	11	tcs	tcs	NOUN
admet-2455	163	12	and	and	CCONJ
admet-2455	163	13	benz	benz	PROPN
admet-2455	163	14	treatment	treatment	NOUN
admet-2455	163	15	in	in	ADP
admet-2455	163	16	hela	hela	PROPN
admet-2455	163	17	and	and	CCONJ
admet-2455	163	18	scc25	scc25	PROPN
admet-2455	163	19	cancer	cancer	NOUN
admet-2455	163	20	cells	cell	NOUN
admet-2455	163	21	compared	compare	VERB
admet-2455	163	22	to	to	ADP
admet-2455	163	23	normal	normal	ADJ
admet-2455	163	24	fibroblasts	fibroblast	NOUN
admet-2455	163	25	.	.	PUNCT
admet-2455	164	1	data	datum	NOUN
admet-2455	164	2	were	be	AUX
admet-2455	164	3	expressed	express	VERB
admet-2455	164	4	as	as	ADP
admet-2455	164	5	mean	mean	NOUN
admet-2455	164	6	±	±	NUM
admet-2455	164	7	se	se	X
admet-2455	164	8	(	(	PUNCT
admet-2455	164	9	n	n	NOUN
admet-2455	164	10	=	=	SYM
admet-2455	164	11	3	3	NUM
admet-2455	164	12	)	)	PUNCT
admet-2455	164	13	;	;	PUNCT
admet-2455	164	14	*	*	PUNCT
admet-2455	164	15	*	*	PUNCT
admet-2455	164	16	represents	represent	VERB
admet-2455	164	17	p<0.01	p<0.01	PROPN
admet-2455	164	18	,	,	PUNCT
admet-2455	164	19	*	*	PUNCT
admet-2455	164	20	*	*	PUNCT
admet-2455	164	21	*	*	PUNCT
admet-2455	164	22	*	*	PUNCT
admet-2455	164	23	represents	represent	VERB
admet-2455	164	24	p	p	PRON
admet-2455	164	25	<	<	X
admet-2455	164	26	0.0001	0.0001	NUM
admet-2455	164	27	.	.	PUNCT
admet-2455	165	1	admet	admet	PROPN
admet-2455	165	2	&	&	CCONJ
admet-2455	165	3	dmpk	dmpk	PROPN
admet-2455	165	4	12(6	12(6	NUM
admet-2455	165	5	)	)	PUNCT
admet-2455	165	6	(	(	PUNCT
admet-2455	165	7	2024	2024	NUM
admet-2455	165	8	)	)	PUNCT
admet-2455	165	9	821	821	NUM
admet-2455	165	10	-	-	SYM
admet-2455	165	11	841	841	NUM
admet-2455	165	12	targeting	targeting	NOUN
admet-2455	165	13	hexokinase	hexokinase	NOUN
admet-2455	165	14	2	2	NUM
admet-2455	165	15	to	to	PART
admet-2455	165	16	enhance	enhance	VERB
admet-2455	165	17	anticancer	anticancer	NOUN
admet-2455	165	18	efficacy	efficacy	NOUN
admet-2455	165	19	of	of	ADP
admet-2455	165	20	trichosanthin	trichosanthin	PROPN
admet-2455	165	21	doi	doi	PROPN
admet-2455	165	22	:	:	PUNCT
admet-2455	165	23	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	ADJ
admet-2455	165	24	829	829	NUM
admet-2455	165	25	table	table	NOUN
admet-2455	165	26	1	1	NUM
admet-2455	165	27	.	.	PUNCT
admet-2455	166	1	the	the	DET
admet-2455	166	2	ic50	ic50	PROPN
admet-2455	166	3	values	value	NOUN
admet-2455	166	4	of	of	ADP
admet-2455	166	5	tcs	tcs	NOUN
admet-2455	166	6	and	and	CCONJ
admet-2455	166	7	benz	benz	PROPN
admet-2455	166	8	in	in	ADP
admet-2455	166	9	hela	hela	PROPN
admet-2455	166	10	and	and	CCONJ
admet-2455	166	11	scc25	scc25	PROPN
admet-2455	166	12	cells.a	cells.a	PROPN
admet-2455	166	13	cell	cell	NOUN
admet-2455	166	14	line	line	NOUN
admet-2455	166	15	tcs	tcs	PROPN
admet-2455	166	16	ic50	ic50	PROPN
admet-2455	166	17	/	/	SYM
admet-2455	166	18	μg	μg	PROPN
admet-2455	166	19	ml-1	ml-1	PROPN
admet-2455	167	1	benz	benz	PROPN
admet-2455	167	2	ic50	ic50	PROPN
admet-2455	167	3	/	/	SYM
admet-2455	167	4	μm	μm	NOUN
admet-2455	167	5	hela	hela	ADJ
admet-2455	167	6	24.08	24.08	NUM
admet-2455	167	7	±	±	NUM
admet-2455	167	8	2.29	2.29	NUM
admet-2455	167	9	29.34	29.34	NUM
admet-2455	167	10	±	±	NUM
admet-2455	167	11	0.12	0.12	NUM
admet-2455	167	12	scc25	scc25	PROPN
admet-2455	167	13	12.28	12.28	NUM
admet-2455	167	14	±	±	NUM
admet-2455	167	15	1.90	1.90	NUM
admet-2455	167	16	18.31	18.31	NUM
admet-2455	167	17	±	±	NUM
admet-2455	167	18	1.50	1.50	NUM
admet-2455	167	19	adata	adata	NOUN
admet-2455	167	20	was	be	AUX
admet-2455	167	21	presented	present	VERB
admet-2455	167	22	as	as	ADP
admet-2455	167	23	mean	mean	NOUN
admet-2455	167	24	±	±	NUM
admet-2455	167	25	sd	sd	NOUN
admet-2455	167	26	(	(	PUNCT
admet-2455	167	27	n	n	NOUN
admet-2455	167	28	=	=	SYM
admet-2455	167	29	3	3	NUM
admet-2455	167	30	)	)	PUNCT
admet-2455	167	31	.	.	PUNCT
admet-2455	168	1	table	table	NOUN
admet-2455	168	2	2	2	NUM
admet-2455	168	3	.	.	PUNCT
admet-2455	168	4	treatment	treatment	NOUN
admet-2455	168	5	concentrations	concentration	NOUN
admet-2455	168	6	,	,	PUNCT
admet-2455	168	7	fa	fa	NOUN
admet-2455	168	8	values	value	NOUN
admet-2455	168	9	and	and	CCONJ
admet-2455	168	10	ci	ci	NOUN
admet-2455	168	11	values	value	NOUN
admet-2455	168	12	for	for	ADP
admet-2455	168	13	tcs	tcs	PROPN
admet-2455	168	14	and	and	CCONJ
admet-2455	168	15	benz	benz	PROPN
admet-2455	168	16	combination	combination	NOUN
admet-2455	168	17	in	in	ADP
admet-2455	168	18	hela	hela	ADJ
admet-2455	168	19	cells	cell	NOUN
admet-2455	168	20	(	(	PUNCT
admet-2455	168	21	n	n	NOUN
admet-2455	168	22	=	=	SYM
admet-2455	168	23	3	3	NUM
admet-2455	168	24	)	)	PUNCT
admet-2455	168	25	.	.	PUNCT
admet-2455	169	1	treatment	treatment	NOUN
admet-2455	169	2	group	group	NOUN
admet-2455	169	3	tcs	tcs	PROPN
admet-2455	169	4	ic50	ic50	PROPN
admet-2455	169	5	/	/	SYM
admet-2455	169	6	μg	μg	PROPN
admet-2455	169	7	ml-1	ml-1	PROPN
admet-2455	169	8	benz	benz	PROPN
admet-2455	170	1	ic50	ic50	PROPN
admet-2455	170	2	/	/	SYM
admet-2455	170	3	μm	μm	INTJ
admet-2455	170	4	fa	fa	INTJ
admet-2455	170	5	ci	ci	PROPN
admet-2455	170	6	1	1	NUM
admet-2455	170	7	3.13	3.13	NUM
admet-2455	170	8	25.00	25.00	NUM
admet-2455	170	9	0.79	0.79	NUM
admet-2455	170	10	0.58	0.58	NUM
admet-2455	170	11	2	2	NUM
admet-2455	170	12	6.25	6.25	NUM
admet-2455	170	13	25.00	25.00	NUM
admet-2455	170	14	0.88	0.88	NUM
admet-2455	170	15	0.33	0.33	NUM
admet-2455	170	16	3	3	NUM
admet-2455	170	17	12.50	12.50	NUM
admet-2455	170	18	25.00	25.00	NUM
admet-2455	170	19	0.93	0.93	NUM
admet-2455	170	20	0.22	0.22	NUM
admet-2455	170	21	4	4	NUM
admet-2455	170	22	25.00	25.00	NUM
admet-2455	170	23	25.00	25.00	NUM
admet-2455	170	24	0.95	0.95	NUM
admet-2455	170	25	0.19	0.19	NUM
admet-2455	170	26	5	5	NUM
admet-2455	170	27	50.00	50.00	NUM
admet-2455	170	28	25.00	25.00	NUM
admet-2455	170	29	0.95	0.95	NUM
admet-2455	170	30	0.29	0.29	NUM
admet-2455	170	31	6	6	NUM
admet-2455	170	32	100.00	100.00	NUM
admet-2455	170	33	25.00	25.00	NUM
admet-2455	170	34	0.96	0.96	NUM
admet-2455	170	35	0.39	0.39	NUM
admet-2455	170	36	table	table	NOUN
admet-2455	170	37	3	3	NUM
admet-2455	170	38	.	.	PUNCT
admet-2455	170	39	treatment	treatment	NOUN
admet-2455	170	40	concentrations	concentration	NOUN
admet-2455	170	41	,	,	PUNCT
admet-2455	170	42	fa	fa	NOUN
admet-2455	170	43	values	value	NOUN
admet-2455	170	44	and	and	CCONJ
admet-2455	170	45	ci	ci	NOUN
admet-2455	170	46	values	value	NOUN
admet-2455	170	47	for	for	ADP
admet-2455	170	48	tcs	tcs	PROPN
admet-2455	170	49	and	and	CCONJ
admet-2455	170	50	benz	benz	PROPN
admet-2455	170	51	combination	combination	NOUN
admet-2455	170	52	in	in	ADP
admet-2455	170	53	scc25	scc25	ADJ
admet-2455	170	54	cells	cell	NOUN
admet-2455	170	55	(	(	PUNCT
admet-2455	170	56	n	n	NOUN
admet-2455	170	57	=	=	SYM
admet-2455	170	58	3	3	NUM
admet-2455	170	59	)	)	PUNCT
admet-2455	170	60	.	.	PUNCT
admet-2455	171	1	treatment	treatment	NOUN
admet-2455	171	2	group	group	NOUN
admet-2455	171	3	tcs	tcs	PROPN
admet-2455	171	4	ic50	ic50	PROPN
admet-2455	171	5	/	/	SYM
admet-2455	171	6	μg	μg	PROPN
admet-2455	171	7	ml-1	ml-1	PROPN
admet-2455	171	8	benz	benz	PROPN
admet-2455	172	1	ic50	ic50	PROPN
admet-2455	172	2	/	/	SYM
admet-2455	172	3	μm	μm	INTJ
admet-2455	172	4	fa	fa	INTJ
admet-2455	172	5	ci	ci	PROPN
admet-2455	172	6	1	1	NUM
admet-2455	172	7	0.78	0.78	NUM
admet-2455	172	8	25.00	25.00	NUM
admet-2455	172	9	0.86	0.86	NUM
admet-2455	172	10	0.40	0.40	NUM
admet-2455	172	11	2	2	NUM
admet-2455	172	12	1.56	1.56	NUM
admet-2455	172	13	25.00	25.00	NUM
admet-2455	172	14	0.90	0.90	NUM
admet-2455	172	15	0.32	0.32	NUM
admet-2455	172	16	3	3	NUM
admet-2455	172	17	3.13	3.13	NUM
admet-2455	172	18	25.00	25.00	NUM
admet-2455	172	19	0.93	0.93	NUM
admet-2455	172	20	0.29	0.29	NUM
admet-2455	172	21	4	4	NUM
admet-2455	172	22	6.25	6.25	NUM
admet-2455	172	23	25.00	25.00	NUM
admet-2455	172	24	0.93	0.93	NUM
admet-2455	172	25	0.30	0.30	NUM
admet-2455	172	26	5	5	NUM
admet-2455	172	27	12.50	12.50	NUM
admet-2455	172	28	25.00	25.00	NUM
admet-2455	172	29	0.94	0.94	NUM
admet-2455	172	30	0.33	0.33	NUM
admet-2455	172	31	6	6	NUM
admet-2455	172	32	50.00	50.00	NUM
admet-2455	172	33	25.00	25.00	NUM
admet-2455	172	34	0.95	0.95	NUM
admet-2455	172	35	0.40	0.40	NUM
admet-2455	172	36	combination	combination	NOUN
admet-2455	172	37	of	of	ADP
admet-2455	172	38	tcs	tcs	NOUN
admet-2455	172	39	and	and	CCONJ
admet-2455	172	40	benz	benz	PROPN
admet-2455	172	41	significantly	significantly	ADV
admet-2455	172	42	decreased	decrease	VERB
admet-2455	172	43	cellular	cellular	ADJ
admet-2455	172	44	glycolysis	glycolysis	NOUN
admet-2455	172	45	and	and	CCONJ
admet-2455	172	46	atp	atp	NOUN
admet-2455	172	47	levels	level	NOUN
admet-2455	172	48	next	next	ADV
admet-2455	172	49	,	,	PUNCT
admet-2455	172	50	the	the	DET
admet-2455	172	51	changes	change	NOUN
admet-2455	172	52	of	of	ADP
admet-2455	172	53	metabolic	metabolic	NOUN
admet-2455	172	54	profile	profile	NOUN
admet-2455	172	55	associated	associate	VERB
admet-2455	172	56	with	with	ADP
admet-2455	172	57	glycolysis	glycolysis	NOUN
admet-2455	172	58	were	be	AUX
admet-2455	172	59	measured	measure	VERB
admet-2455	172	60	by	by	ADP
admet-2455	172	61	seahorse	seahorse	NOUN
admet-2455	172	62	assay	assay	NOUN
admet-2455	172	63	.	.	PUNCT
admet-2455	173	1	hela	hela	PROPN
admet-2455	173	2	cells	cell	NOUN
admet-2455	173	3	were	be	AUX
admet-2455	173	4	treated	treat	VERB
admet-2455	173	5	with	with	ADP
admet-2455	173	6	50	50	NUM
admet-2455	173	7	μg	μg	NOUN
admet-2455	173	8	/	/	SYM
admet-2455	173	9	ml	ml	NOUN
admet-2455	173	10	tcs	tcs	NOUN
admet-2455	173	11	and	and	CCONJ
admet-2455	173	12	50	50	NUM
admet-2455	173	13	μm	μm	NOUN
admet-2455	173	14	benz	benz	PROPN
admet-2455	173	15	,	,	PUNCT
admet-2455	173	16	alone	alone	ADJ
admet-2455	173	17	or	or	CCONJ
admet-2455	173	18	in	in	ADP
admet-2455	173	19	combined	combine	VERB
admet-2455	173	20	,	,	PUNCT
admet-2455	173	21	for	for	ADP
admet-2455	173	22	18	18	NUM
admet-2455	173	23	h	h	NOUN
admet-2455	173	24	prior	prior	ADV
admet-2455	173	25	to	to	ADP
admet-2455	173	26	measuring	measure	VERB
admet-2455	173	27	extracellular	extracellular	ADJ
admet-2455	173	28	acidification	acidification	NOUN
admet-2455	173	29	rate	rate	NOUN
admet-2455	173	30	(	(	PUNCT
admet-2455	173	31	ecar	ecar	NOUN
admet-2455	173	32	)	)	PUNCT
admet-2455	173	33	.	.	PUNCT
admet-2455	174	1	scc25	scc25	PROPN
admet-2455	174	2	cells	cell	NOUN
admet-2455	174	3	were	be	AUX
admet-2455	174	4	treated	treat	VERB
admet-2455	174	5	with	with	ADP
admet-2455	174	6	25	25	NUM
admet-2455	174	7	μg	μg	PROPN
admet-2455	174	8	/	/	SYM
admet-2455	174	9	ml	ml	NOUN
admet-2455	174	10	tcs	tcs	NOUN
admet-2455	174	11	and	and	CCONJ
admet-2455	174	12	25	25	NUM
admet-2455	174	13	μm	μm	NUM
admet-2455	174	14	benz	benz	PROPN
admet-2455	174	15	,	,	PUNCT
admet-2455	174	16	alone	alone	ADJ
admet-2455	174	17	or	or	CCONJ
admet-2455	174	18	in	in	ADP
admet-2455	174	19	combined	combine	VERB
admet-2455	174	20	,	,	PUNCT
admet-2455	174	21	for	for	ADP
admet-2455	174	22	18	18	NUM
admet-2455	174	23	h	h	NOUN
admet-2455	174	24	,	,	PUNCT
admet-2455	174	25	followed	follow	VERB
admet-2455	174	26	by	by	ADP
admet-2455	174	27	seahorse	seahorse	NOUN
admet-2455	174	28	assay	assay	NOUN
admet-2455	174	29	.	.	PUNCT
admet-2455	175	1	compared	compare	VERB
admet-2455	175	2	to	to	ADP
admet-2455	175	3	single	single	ADJ
admet-2455	175	4	treatment	treatment	NOUN
admet-2455	175	5	of	of	ADP
admet-2455	175	6	tcs	tcs	NOUN
admet-2455	175	7	or	or	CCONJ
admet-2455	175	8	benz	benz	PROPN
admet-2455	175	9	,	,	PUNCT
admet-2455	175	10	the	the	DET
admet-2455	175	11	combined	combine	VERB
admet-2455	175	12	treatment	treatment	NOUN
admet-2455	175	13	decreased	decrease	VERB
admet-2455	175	14	ecar	ecar	ADJ
admet-2455	175	15	profiles	profile	NOUN
admet-2455	175	16	in	in	ADP
admet-2455	175	17	both	both	CCONJ
admet-2455	175	18	hela	hela	PROPN
admet-2455	175	19	and	and	CCONJ
admet-2455	175	20	scc25	scc25	PROPN
admet-2455	175	21	cells	cell	NOUN
admet-2455	175	22	,	,	PUNCT
admet-2455	175	23	suggesting	suggest	VERB
admet-2455	175	24	attenuated	attenuate	VERB
admet-2455	175	25	glycolytic	glycolytic	ADJ
admet-2455	175	26	function	function	NOUN
admet-2455	175	27	(	(	PUNCT
admet-2455	175	28	figure	figure	NOUN
admet-2455	175	29	3a	3a	NUM
admet-2455	175	30	,	,	PUNCT
admet-2455	175	31	b	b	NOUN
admet-2455	175	32	)	)	PUNCT
admet-2455	175	33	.	.	PUNCT
admet-2455	176	1	quantitative	quantitative	ADJ
admet-2455	176	2	analyses	analysis	NOUN
admet-2455	176	3	on	on	ADP
admet-2455	176	4	the	the	DET
admet-2455	176	5	ecar	ecar	NOUN
admet-2455	176	6	profile	profile	NOUN
admet-2455	176	7	data	datum	NOUN
admet-2455	176	8	showed	show	VERB
admet-2455	176	9	that	that	SCONJ
admet-2455	176	10	this	this	DET
admet-2455	176	11	combination	combination	NOUN
admet-2455	176	12	markedly	markedly	ADV
admet-2455	176	13	reduced	reduce	VERB
admet-2455	176	14	basal	basal	NOUN
admet-2455	176	15	glycolysis	glycolysis	NOUN
admet-2455	176	16	,	,	PUNCT
admet-2455	176	17	glycollysis	glycollysis	NOUN
admet-2455	176	18	capacity	capacity	NOUN
admet-2455	176	19	,	,	PUNCT
admet-2455	176	20	and	and	CCONJ
admet-2455	176	21	glycolysis	glycolysis	NOUN
admet-2455	176	22	reserve	reserve	NOUN
admet-2455	176	23	in	in	ADP
admet-2455	176	24	hela	hela	PROPN
admet-2455	176	25	and	and	CCONJ
admet-2455	176	26	scc25	scc25	PROPN
admet-2455	176	27	cells	cell	NOUN
admet-2455	176	28	(	(	PUNCT
admet-2455	176	29	figure	figure	NOUN
admet-2455	176	30	3c	3c	NUM
admet-2455	176	31	,	,	PUNCT
admet-2455	176	32	3d	3d	NUM
admet-2455	176	33	and	and	CCONJ
admet-2455	176	34	3e	3e	NUM
admet-2455	176	35	)	)	PUNCT
admet-2455	176	36	.	.	PUNCT
admet-2455	177	1	moreover	moreover	ADV
admet-2455	177	2	,	,	PUNCT
admet-2455	177	3	24	24	NUM
admet-2455	177	4	h	h	NOUN
admet-2455	177	5	of	of	ADP
admet-2455	177	6	tcs	tcs	NOUN
admet-2455	177	7	combined	combine	VERB
admet-2455	177	8	with	with	ADP
admet-2455	177	9	benz	benz	PROPN
admet-2455	177	10	treatments	treatment	NOUN
admet-2455	177	11	resulted	result	VERB
admet-2455	177	12	in	in	ADP
admet-2455	177	13	dramatic	dramatic	ADJ
admet-2455	177	14	decreasing	decreasing	NOUN
admet-2455	177	15	of	of	ADP
admet-2455	177	16	cellular	cellular	ADJ
admet-2455	177	17	atp	atp	NOUN
admet-2455	177	18	production	production	NOUN
admet-2455	177	19	in	in	ADP
admet-2455	177	20	both	both	DET
admet-2455	177	21	cell	cell	NOUN
admet-2455	177	22	lines	line	NOUN
admet-2455	177	23	(	(	PUNCT
admet-2455	177	24	figure	figure	NOUN
admet-2455	177	25	3f	3f	PROPN
admet-2455	177	26	)	)	PUNCT
admet-2455	177	27	.	.	PUNCT
admet-2455	178	1	tcs	tcs	PROPN
admet-2455	178	2	and	and	CCONJ
admet-2455	178	3	benz	benz	PROPN
admet-2455	178	4	combination	combination	NOUN
admet-2455	178	5	lowered	lower	VERB
admet-2455	178	6	lactate	lactate	NOUN
admet-2455	178	7	secretion	secretion	NOUN
admet-2455	178	8	and	and	CCONJ
admet-2455	178	9	suppressed	suppress	VERB
admet-2455	178	10	colony	colony	NOUN
admet-2455	178	11	-	-	PUNCT
admet-2455	178	12	forming	form	VERB
admet-2455	178	13	ability	ability	NOUN
admet-2455	178	14	the	the	DET
admet-2455	178	15	byproduct	byproduct	NOUN
admet-2455	178	16	of	of	ADP
admet-2455	178	17	glycolysis	glycolysis	NOUN
admet-2455	178	18	,	,	PUNCT
admet-2455	178	19	lactate	lactate	NOUN
admet-2455	178	20	,	,	PUNCT
admet-2455	178	21	was	be	AUX
admet-2455	178	22	measured	measure	VERB
admet-2455	178	23	and	and	CCONJ
admet-2455	178	24	quantified	quantify	VERB
admet-2455	178	25	by	by	ADP
admet-2455	178	26	nova	nova	PROPN
admet-2455	178	27	bioprofile	bioprofile	NOUN
admet-2455	178	28	flex	flex	ADJ
admet-2455	178	29	analyzer	analyzer	NOUN
admet-2455	178	30	.	.	PUNCT
admet-2455	179	1	after	after	ADP
admet-2455	179	2	24	24	NUM
admet-2455	179	3	h	h	NOUN
admet-2455	179	4	,	,	PUNCT
admet-2455	179	5	the	the	DET
admet-2455	179	6	tcs	tcs	PROPN
admet-2455	179	7	-	-	PUNCT
admet-2455	179	8	benz	benz	PROPN
admet-2455	179	9	combo	combo	PROPN
admet-2455	179	10	significantly	significantly	ADV
admet-2455	179	11	reduced	reduce	VERB
admet-2455	179	12	the	the	DET
admet-2455	179	13	extracellular	extracellular	ADJ
admet-2455	179	14	lactate	lactate	NOUN
admet-2455	179	15	levels	level	NOUN
admet-2455	179	16	in	in	ADP
admet-2455	179	17	both	both	CCONJ
admet-2455	179	18	hela	hela	PROPN
admet-2455	179	19	and	and	CCONJ
admet-2455	179	20	scc25	scc25	PROPN
admet-2455	179	21	cells	cell	NOUN
admet-2455	179	22	(	(	PUNCT
admet-2455	179	23	figures	figure	NOUN
admet-2455	179	24	4a	4a	NOUN
admet-2455	179	25	and	and	CCONJ
admet-2455	179	26	4b	4b	NUM
admet-2455	179	27	)	)	PUNCT
admet-2455	179	28	.	.	PUNCT
admet-2455	180	1	lactate	lactate	PROPN
admet-2455	180	2	generated	generate	VERB
admet-2455	180	3	via	via	ADP
admet-2455	180	4	glycolysis	glycolysis	NOUN
admet-2455	180	5	was	be	AUX
admet-2455	180	6	known	know	VERB
admet-2455	180	7	for	for	ADP
admet-2455	180	8	promoting	promote	VERB
admet-2455	180	9	cancer	cancer	NOUN
admet-2455	180	10	cell	cell	NOUN
admet-2455	180	11	colony	colony	NOUN
admet-2455	180	12	formation	formation	NOUN
admet-2455	180	13	and	and	CCONJ
admet-2455	180	14	survival	survival	NOUN
admet-2455	180	15	by	by	ADP
admet-2455	180	16	providing	provide	VERB
admet-2455	180	17	energy	energy	NOUN
admet-2455	180	18	and	and	CCONJ
admet-2455	180	19	creating	create	VERB
admet-2455	180	20	an	an	DET
admet-2455	180	21	acidic	acidic	ADJ
admet-2455	180	22	microenvironment	microenvironment	NOUN
admet-2455	180	23	.	.	PUNCT
admet-2455	181	1	in	in	ADP
admet-2455	181	2	hela	hela	PROPN
admet-2455	181	3	and	and	CCONJ
admet-2455	181	4	scc25	scc25	PROPN
admet-2455	181	5	cells	cell	NOUN
admet-2455	181	6	,	,	PUNCT
admet-2455	181	7	tcs	tcs	PROPN
admet-2455	181	8	-	-	PUNCT
admet-2455	181	9	benz	benz	PROPN
admet-2455	181	10	combo	combo	PROPN
admet-2455	181	11	significantly	significantly	ADV
admet-2455	181	12	reduced	reduce	VERB
admet-2455	181	13	colony	colony	NOUN
admet-2455	181	14	size	size	NOUN
admet-2455	181	15	and	and	CCONJ
admet-2455	181	16	numbers	number	NOUN
admet-2455	181	17	as	as	SCONJ
admet-2455	181	18	compared	compare	VERB
admet-2455	181	19	with	with	ADP
admet-2455	181	20	single	single	ADJ
admet-2455	181	21	treatment	treatment	NOUN
admet-2455	181	22	,	,	PUNCT
admet-2455	181	23	indicating	indicate	VERB
admet-2455	181	24	the	the	DET
admet-2455	181	25	proliferative	proliferative	ADJ
admet-2455	181	26	capacity	capacity	NOUN
admet-2455	181	27	of	of	ADP
admet-2455	181	28	cancer	cancer	NOUN
admet-2455	181	29	cells	cell	NOUN
admet-2455	181	30	was	be	AUX
admet-2455	181	31	effectively	effectively	ADV
admet-2455	181	32	attenuated	attenuate	VERB
admet-2455	181	33	(	(	PUNCT
admet-2455	181	34	figures	figure	NOUN
admet-2455	181	35	4c	4c	NOUN
admet-2455	181	36	and	and	CCONJ
admet-2455	181	37	4d	4d	NUM
admet-2455	181	38	)	)	PUNCT
admet-2455	181	39	.	.	PUNCT
admet-2455	182	1	tcs	tcs	PROPN
admet-2455	182	2	combined	combine	VERB
admet-2455	182	3	with	with	ADP
admet-2455	182	4	benz	benz	PROPN
admet-2455	182	5	induced	induce	VERB
admet-2455	182	6	cell	cell	NOUN
admet-2455	182	7	cycle	cycle	NOUN
admet-2455	182	8	arrest	arrest	NOUN
admet-2455	182	9	in	in	ADP
admet-2455	182	10	hela	hela	PROPN
admet-2455	182	11	and	and	CCONJ
admet-2455	182	12	scc25	scc25	PROPN
admet-2455	182	13	cells	cell	NOUN
admet-2455	182	14	to	to	PART
admet-2455	182	15	investigate	investigate	VERB
admet-2455	182	16	the	the	DET
admet-2455	182	17	impact	impact	NOUN
admet-2455	182	18	of	of	ADP
admet-2455	182	19	the	the	DET
admet-2455	182	20	combined	combine	VERB
admet-2455	182	21	use	use	NOUN
admet-2455	182	22	of	of	ADP
admet-2455	182	23	tcs	tcs	NOUN
admet-2455	182	24	and	and	CCONJ
admet-2455	182	25	benz	benz	PROPN
admet-2455	182	26	on	on	ADP
admet-2455	182	27	growth	growth	NOUN
admet-2455	182	28	and	and	CCONJ
admet-2455	182	29	mitosis	mitosis	NOUN
admet-2455	182	30	in	in	ADP
admet-2455	182	31	hela	hela	PROPN
admet-2455	182	32	and	and	CCONJ
admet-2455	182	33	scc25	scc25	PROPN
admet-2455	182	34	cells	cell	NOUN
admet-2455	182	35	,	,	PUNCT
admet-2455	182	36	the	the	DET
admet-2455	182	37	cell	cell	NOUN
admet-2455	182	38	cycle	cycle	NOUN
admet-2455	182	39	distribution	distribution	NOUN
admet-2455	182	40	was	be	AUX
admet-2455	182	41	analysed	analyse	VERB
admet-2455	182	42	using	use	VERB
admet-2455	182	43	a	a	DET
admet-2455	182	44	cyto	cyto	ADJ
admet-2455	182	45	-	-	PUNCT
admet-2455	182	46	flex	flex	ADJ
admet-2455	182	47	flow	flow	NOUN
admet-2455	182	48	cytometer	cytometer	NOUN
admet-2455	182	49	.	.	PUNCT
admet-2455	183	1	compared	compare	VERB
admet-2455	183	2	to	to	ADP
admet-2455	183	3	the	the	DET
admet-2455	183	4	control	control	NOUN
admet-2455	183	5	group	group	NOUN
admet-2455	183	6	and	and	CCONJ
admet-2455	183	7	single	single	ADJ
admet-2455	183	8	treatment	treatment	NOUN
admet-2455	183	9	groups	group	NOUN
admet-2455	183	10	,	,	PUNCT
admet-2455	183	11	the	the	DET
admet-2455	183	12	combination	combination	NOUN
admet-2455	183	13	treatment	treatment	NOUN
admet-2455	183	14	group	group	NOUN
admet-2455	183	15	exhibited	exhibit	VERB
admet-2455	183	16	significant	significant	ADJ
admet-2455	183	17	increase	increase	NOUN
admet-2455	183	18	in	in	ADP
admet-2455	183	19	the	the	DET
admet-2455	183	20	g0	g0	PROPN
admet-2455	183	21	/	/	SYM
admet-2455	183	22	g1	g1	PROPN
admet-2455	183	23	phase	phase	NOUN
admet-2455	183	24	,	,	PUNCT
admet-2455	183	25	accompanied	accompany	VERB
admet-2455	183	26	by	by	ADP
admet-2455	183	27	a	a	DET
admet-2455	183	28	decrease	decrease	NOUN
admet-2455	183	29	in	in	ADP
admet-2455	183	30	the	the	DET
admet-2455	183	31	s	s	NOUN
admet-2455	183	32	and	and	CCONJ
admet-2455	183	33	g2	g2	PROPN
admet-2455	183	34	/	/	SYM
admet-2455	183	35	m	m	PROPN
admet-2455	183	36	phases	phase	NOUN
admet-2455	183	37	,	,	PUNCT
admet-2455	183	38	suggesting	suggest	VERB
admet-2455	183	39	induction	induction	NOUN
admet-2455	183	40	of	of	ADP
admet-2455	183	41	cell	cell	NOUN
admet-2455	183	42	cycle	cycle	NOUN
admet-2455	183	43	arrest	arrest	NOUN
admet-2455	183	44	at	at	ADP
admet-2455	183	45	the	the	DET
admet-2455	183	46	g0	g0	PROPN
admet-2455	183	47	/	/	SYM
admet-2455	183	48	g1	g1	PROPN
admet-2455	183	49	phase	phase	NOUN
admet-2455	183	50	while	while	SCONJ
admet-2455	183	51	inhibition	inhibition	NOUN
admet-2455	183	52	of	of	ADP
admet-2455	183	53	the	the	DET
admet-2455	183	54	transition	transition	NOUN
admet-2455	183	55	to	to	ADP
admet-2455	183	56	the	the	DET
admet-2455	183	57	g2	g2	PROPN
admet-2455	183	58	/	/	SYM
admet-2455	183	59	m	m	PROPN
admet-2455	183	60	phase	phase	NOUN
admet-2455	183	61	in	in	ADP
admet-2455	183	62	hela	hela	PROPN
admet-2455	183	63	cells	cell	NOUN
admet-2455	183	64	(	(	PUNCT
admet-2455	183	65	figures	figure	NOUN
admet-2455	183	66	5a	5a	NUM
admet-2455	183	67	and	and	CCONJ
admet-2455	183	68	5b	5b	NUM
admet-2455	183	69	)	)	PUNCT
admet-2455	183	70	.	.	PUNCT
admet-2455	184	1	similarly	similarly	ADV
admet-2455	184	2	,	,	PUNCT
admet-2455	184	3	in	in	ADP
admet-2455	184	4	scc25	scc25	ADJ
admet-2455	184	5	cells	cell	NOUN
admet-2455	184	6	,	,	PUNCT
admet-2455	184	7	the	the	DET
admet-2455	184	8	combination	combination	NOUN
admet-2455	184	9	treatment	treatment	NOUN
admet-2455	184	10	also	also	ADV
admet-2455	184	11	led	lead	VERB
admet-2455	184	12	to	to	ADP
admet-2455	184	13	cell	cell	NOUN
admet-2455	184	14	cycle	cycle	NOUN
admet-2455	184	15	arrest	arrest	NOUN
admet-2455	184	16	at	at	ADP
admet-2455	184	17	the	the	DET
admet-2455	184	18	g0	g0	PROPN
admet-2455	184	19	/	/	SYM
admet-2455	184	20	g1	g1	PROPN
admet-2455	184	21	phase	phase	NOUN
admet-2455	184	22	and	and	CCONJ
admet-2455	184	23	blocking	blocking	NOUN
admet-2455	184	24	of	of	ADP
admet-2455	184	25	g2	g2	PROPN
admet-2455	184	26	/	/	SYM
admet-2455	184	27	m	m	PROPN
admet-2455	184	28	phase	phase	NOUN
admet-2455	184	29	,	,	PUNCT
admet-2455	184	30	with	with	ADP
admet-2455	184	31	the	the	DET
admet-2455	184	32	exception	exception	NOUN
admet-2455	184	33	that	that	PRON
admet-2455	184	34	the	the	DET
admet-2455	184	35	effects	effect	NOUN
admet-2455	184	36	on	on	ADP
admet-2455	184	37	the	the	DET
admet-2455	184	38	s	s	NOUN
admet-2455	184	39	phase	phase	NOUN
admet-2455	184	40	were	be	AUX
admet-2455	184	41	not	not	PART
admet-2455	184	42	statistically	statistically	ADV
admet-2455	184	43	significant	significant	ADJ
admet-2455	184	44	(	(	PUNCT
admet-2455	184	45	figures	figure	NOUN
admet-2455	184	46	5c	5c	NUM
admet-2455	184	47	and	and	CCONJ
admet-2455	184	48	5d	5d	NUM
admet-2455	184	49	)	)	PUNCT
admet-2455	184	50	.	.	PUNCT
admet-2455	185	1	these	these	DET
admet-2455	185	2	results	result	NOUN
admet-2455	185	3	revealed	reveal	VERB
admet-2455	185	4	that	that	SCONJ
admet-2455	185	5	the	the	DET
admet-2455	185	6	combination	combination	NOUN
admet-2455	185	7	of	of	ADP
admet-2455	185	8	tcs	tcs	NOUN
admet-2455	185	9	and	and	CCONJ
admet-2455	185	10	benz	benz	PROPN
admet-2455	185	11	exerted	exert	VERB
admet-2455	185	12	a	a	DET
admet-2455	185	13	regulatory	regulatory	ADJ
admet-2455	185	14	effect	effect	NOUN
admet-2455	185	15	on	on	ADP
admet-2455	185	16	the	the	DET
admet-2455	185	17	cell	cell	NOUN
admet-2455	185	18	cycle	cycle	NOUN
admet-2455	185	19	progression	progression	NOUN
admet-2455	185	20	,	,	PUNCT
admet-2455	185	21	potentially	potentially	ADV
admet-2455	185	22	contributing	contribute	VERB
admet-2455	185	23	to	to	ADP
admet-2455	185	24	the	the	DET
admet-2455	185	25	inhibition	inhibition	NOUN
admet-2455	185	26	of	of	ADP
admet-2455	185	27	cell	cell	NOUN
admet-2455	185	28	proliferation	proliferation	NOUN
admet-2455	185	29	in	in	ADP
admet-2455	185	30	both	both	CCONJ
admet-2455	185	31	hela	hela	PROPN
admet-2455	185	32	and	and	CCONJ
admet-2455	185	33	scc25	scc25	ADJ
admet-2455	185	34	cells	cell	NOUN
admet-2455	185	35	.	.	PUNCT
admet-2455	186	1	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	X
admet-2455	186	2	y.	y.	NOUN
admet-2455	186	3	zhou	zhou	PROPN
admet-2455	186	4	et	et	PROPN
admet-2455	186	5	al	al	PROPN
admet-2455	186	6	.	.	PROPN
admet-2455	186	7	admet	admet	PROPN
admet-2455	186	8	&	&	CCONJ
admet-2455	186	9	dmpk	dmpk	PROPN
admet-2455	186	10	12(6	12(6	NUM
admet-2455	186	11	)	)	PUNCT
admet-2455	186	12	(	(	PUNCT
admet-2455	186	13	2024	2024	NUM
admet-2455	186	14	)	)	PUNCT
admet-2455	186	15	821	821	NUM
admet-2455	186	16	-	-	SYM
admet-2455	186	17	841	841	NUM
admet-2455	186	18	830	830	NUM
admet-2455	186	19	figure	figure	NOUN
admet-2455	186	20	3	3	NUM
admet-2455	186	21	.	.	PUNCT
admet-2455	186	22	changes	change	NOUN
admet-2455	186	23	in	in	ADP
admet-2455	186	24	metabolic	metabolic	NOUN
admet-2455	186	25	and	and	CCONJ
admet-2455	186	26	energy	energy	NOUN
admet-2455	186	27	parameters	parameter	NOUN
admet-2455	186	28	in	in	ADP
admet-2455	186	29	hela	hela	PROPN
admet-2455	186	30	and	and	CCONJ
admet-2455	186	31	scc25	scc25	PROPN
admet-2455	186	32	cells	cell	NOUN
admet-2455	186	33	exposed	expose	VERB
admet-2455	186	34	to	to	ADP
admet-2455	186	35	tcs	tcs	PROPN
admet-2455	186	36	and	and	CCONJ
admet-2455	186	37	benz	benz	PROPN
admet-2455	186	38	combined	combine	VERB
admet-2455	186	39	treatments	treatment	NOUN
admet-2455	186	40	in	in	ADP
admet-2455	186	41	hela	hela	PROPN
admet-2455	186	42	and	and	CCONJ
admet-2455	186	43	scc25	scc25	PROPN
admet-2455	186	44	cells	cell	NOUN
admet-2455	186	45	.	.	PUNCT
admet-2455	187	1	(	(	PUNCT
admet-2455	187	2	a	a	PRON
admet-2455	187	3	,	,	PUNCT
admet-2455	187	4	b	b	NOUN
admet-2455	187	5	)	)	PUNCT
admet-2455	187	6	ecar	ecar	ADJ
admet-2455	187	7	profiles	profile	NOUN
admet-2455	187	8	of	of	ADP
admet-2455	187	9	drug	drug	NOUN
admet-2455	187	10	-	-	PUNCT
admet-2455	187	11	treated	treat	VERB
admet-2455	187	12	hela	hela	PROPN
admet-2455	187	13	and	and	CCONJ
admet-2455	187	14	scc25	scc25	NOUN
admet-2455	187	15	cells	cell	NOUN
admet-2455	187	16	under	under	ADP
admet-2455	187	17	three	three	NUM
admet-2455	187	18	sequential	sequential	ADJ
admet-2455	187	19	injections	injection	NOUN
admet-2455	187	20	of	of	ADP
admet-2455	187	21	glucose	glucose	NOUN
admet-2455	187	22	(	(	PUNCT
admet-2455	187	23	10	10	NUM
admet-2455	187	24	mm	mm	NOUN
admet-2455	187	25	)	)	PUNCT
admet-2455	187	26	,	,	PUNCT
admet-2455	187	27	oligomycin	oligomycin	INTJ
admet-2455	187	28	(	(	PUNCT
admet-2455	187	29	1	1	NUM
admet-2455	187	30	μm	μm	NUM
admet-2455	187	31	)	)	PUNCT
admet-2455	187	32	,	,	PUNCT
admet-2455	187	33	and	and	CCONJ
admet-2455	187	34	2	2	NUM
admet-2455	187	35	-	-	PUNCT
admet-2455	187	36	deoxyglucose	deoxyglucose	NOUN
admet-2455	187	37	(	(	PUNCT
admet-2455	187	38	2	2	NUM
admet-2455	187	39	-	-	PUNCT
admet-2455	187	40	dg	dg	NOUN
admet-2455	187	41	,	,	PUNCT
admet-2455	187	42	50	50	NUM
admet-2455	187	43	mm	mm	NOUN
admet-2455	187	44	)	)	PUNCT
admet-2455	187	45	.	.	PUNCT
admet-2455	188	1	ecar	ecar	ADJ
admet-2455	188	2	values	value	NOUN
admet-2455	188	3	were	be	AUX
admet-2455	188	4	normalized	normalize	VERB
admet-2455	188	5	to	to	ADP
admet-2455	188	6	cell	cell	NOUN
admet-2455	188	7	numbers	number	NOUN
admet-2455	188	8	.	.	PUNCT
admet-2455	189	1	(	(	PUNCT
admet-2455	189	2	c	c	X
admet-2455	189	3	,	,	PUNCT
admet-2455	189	4	d	d	NOUN
admet-2455	189	5	,	,	PUNCT
admet-2455	189	6	e	e	NOUN
admet-2455	189	7	)	)	PUNCT
admet-2455	189	8	ecar	ecar	NOUN
admet-2455	189	9	data	datum	NOUN
admet-2455	189	10	were	be	AUX
admet-2455	189	11	quantified	quantify	VERB
admet-2455	189	12	to	to	PART
admet-2455	189	13	indicate	indicate	VERB
admet-2455	189	14	basal	basal	ADJ
admet-2455	189	15	glycolysis	glycolysis	NOUN
admet-2455	189	16	,	,	PUNCT
admet-2455	189	17	glycolysis	glycolysis	NOUN
admet-2455	189	18	capacity	capacity	NOUN
admet-2455	189	19	,	,	PUNCT
admet-2455	189	20	and	and	CCONJ
admet-2455	189	21	glycolysis	glycolysis	NOUN
admet-2455	189	22	reserve	reserve	NOUN
admet-2455	189	23	in	in	ADP
admet-2455	189	24	hela	hela	PROPN
admet-2455	189	25	and	and	CCONJ
admet-2455	189	26	scc25	scc25	PROPN
admet-2455	189	27	cells	cell	NOUN
admet-2455	189	28	.	.	PUNCT
admet-2455	190	1	(	(	PUNCT
admet-2455	190	2	f	f	X
admet-2455	190	3	)	)	PUNCT
admet-2455	190	4	measurement	measurement	NOUN
admet-2455	190	5	of	of	ADP
admet-2455	190	6	cellular	cellular	ADJ
admet-2455	190	7	atp	atp	NOUN
admet-2455	190	8	amount	amount	NOUN
admet-2455	190	9	in	in	ADP
admet-2455	190	10	hela	hela	PROPN
admet-2455	190	11	and	and	CCONJ
admet-2455	190	12	scc25	scc25	PROPN
admet-2455	190	13	cells	cell	NOUN
admet-2455	190	14	.	.	PUNCT
admet-2455	191	1	data	datum	NOUN
admet-2455	191	2	were	be	AUX
admet-2455	191	3	presented	present	VERB
admet-2455	191	4	as	as	ADP
admet-2455	191	5	mean	mean	NOUN
admet-2455	191	6	±	±	NUM
admet-2455	191	7	se	se	X
admet-2455	191	8	(	(	PUNCT
admet-2455	191	9	n	n	NOUN
admet-2455	191	10	=	=	SYM
admet-2455	191	11	3	3	NUM
admet-2455	191	12	)	)	PUNCT
admet-2455	191	13	;	;	PUNCT
admet-2455	191	14	ns	ns	NUM
admet-2455	191	15	indicates	indicate	VERB
admet-2455	191	16	non	non	ADJ
admet-2455	191	17	-	-	ADJ
admet-2455	191	18	significant	significant	ADJ
admet-2455	191	19	,	,	PUNCT
admet-2455	191	20	*	*	PUNCT
admet-2455	191	21	represents	represent	VERB
admet-2455	191	22	p	p	PRON
admet-2455	191	23	<	<	X
admet-2455	191	24	0.05	0.05	NUM
admet-2455	191	25	,	,	PUNCT
admet-2455	191	26	*	*	PUNCT
admet-2455	191	27	*	*	PUNCT
admet-2455	191	28	represents	represent	VERB
admet-2455	191	29	p<0.01	p<0.01	PROPN
admet-2455	191	30	,	,	PUNCT
admet-2455	191	31	*	*	PUNCT
admet-2455	191	32	*	*	PUNCT
admet-2455	191	33	*	*	PUNCT
admet-2455	191	34	represents	represent	VERB
admet-2455	191	35	p<0.001	p<0.001	VERB
admet-2455	191	36	,	,	PUNCT
admet-2455	191	37	*	*	PUNCT
admet-2455	191	38	*	*	PUNCT
admet-2455	191	39	*	*	PUNCT
admet-2455	191	40	*	*	PUNCT
admet-2455	191	41	represents	represent	VERB
admet-2455	191	42	p	p	PRON
admet-2455	191	43	<	<	X
admet-2455	191	44	0.0001	0.0001	NUM
admet-2455	191	45	.	.	PUNCT
admet-2455	192	1	tcs	tcs	NOUN
admet-2455	192	2	combined	combine	VERB
admet-2455	192	3	with	with	ADP
admet-2455	192	4	benz	benz	PROPN
admet-2455	192	5	to	to	PART
admet-2455	192	6	elevate	elevate	VERB
admet-2455	192	7	cellular	cellular	ADJ
admet-2455	192	8	ros	ros	PROPN
admet-2455	192	9	accumulation	accumulation	NOUN
admet-2455	192	10	and	and	CCONJ
admet-2455	192	11	trigger	trigger	NOUN
admet-2455	192	12	mitochondria	mitochondria	NOUN
admet-2455	192	13	associated	associate	VERB
admet-2455	192	14	cell	cell	NOUN
admet-2455	192	15	apoptosis	apoptosis	NOUN
admet-2455	192	16	previous	previous	ADJ
admet-2455	192	17	research	research	NOUN
admet-2455	192	18	has	have	AUX
admet-2455	192	19	shown	show	VERB
admet-2455	192	20	that	that	SCONJ
admet-2455	192	21	inhibiting	inhibit	VERB
admet-2455	192	22	aerobic	aerobic	ADJ
admet-2455	192	23	glycolysis	glycolysis	NOUN
admet-2455	192	24	in	in	ADP
admet-2455	192	25	cancer	cancer	NOUN
admet-2455	192	26	cells	cell	NOUN
admet-2455	192	27	may	may	AUX
admet-2455	192	28	cause	cause	VERB
admet-2455	192	29	damage	damage	NOUN
admet-2455	192	30	to	to	ADP
admet-2455	192	31	mitochondria	mitochondria	NOUN
admet-2455	192	32	through	through	ADP
admet-2455	192	33	ros	ros	PROPN
admet-2455	192	34	,	,	PUNCT
admet-2455	192	35	ultimately	ultimately	ADV
admet-2455	192	36	leading	lead	VERB
admet-2455	192	37	to	to	ADP
admet-2455	192	38	increased	increase	VERB
admet-2455	192	39	apoptosis	apoptosis	NOUN
admet-2455	192	40	[	[	X
admet-2455	192	41	34	34	NUM
admet-2455	192	42	-	-	SYM
admet-2455	192	43	36	36	NUM
admet-2455	192	44	]	]	PUNCT
admet-2455	192	45	.	.	PUNCT
admet-2455	193	1	tcs	tcs	PROPN
admet-2455	193	2	has	have	AUX
admet-2455	193	3	also	also	ADV
admet-2455	193	4	been	be	AUX
admet-2455	193	5	found	find	VERB
admet-2455	193	6	to	to	PART
admet-2455	193	7	induce	induce	VERB
admet-2455	193	8	ros	ros	PROPN
admet-2455	193	9	as	as	ADP
admet-2455	193	10	an	an	DET
admet-2455	193	11	anticancer	anticancer	NOUN
admet-2455	193	12	mechanism	mechanism	NOUN
admet-2455	193	13	[	[	X
admet-2455	193	14	37	37	NUM
admet-2455	193	15	-	-	SYM
admet-2455	193	16	39	39	NUM
admet-2455	193	17	]	]	PUNCT
admet-2455	193	18	.	.	PUNCT
admet-2455	194	1	as	as	SCONJ
admet-2455	194	2	shown	show	VERB
admet-2455	194	3	in	in	ADP
admet-2455	194	4	figure	figure	NOUN
admet-2455	194	5	6a	6a	NOUN
admet-2455	194	6	,	,	PUNCT
admet-2455	194	7	combined	combined	ADJ
admet-2455	194	8	use	use	NOUN
admet-2455	194	9	of	of	ADP
admet-2455	194	10	tcs	tcs	NOUN
admet-2455	194	11	and	and	CCONJ
admet-2455	194	12	benz	benz	PROPN
admet-2455	194	13	resulted	result	VERB
admet-2455	194	14	in	in	ADP
admet-2455	194	15	dramatic	dramatic	ADJ
admet-2455	194	16	increase	increase	NOUN
admet-2455	194	17	in	in	ADP
admet-2455	194	18	intracellular	intracellular	ADJ
admet-2455	194	19	ros	ro	NOUN
admet-2455	194	20	,	,	PUNCT
admet-2455	194	21	suggesting	suggest	VERB
admet-2455	194	22	potential	potential	ADJ
admet-2455	194	23	metabolic	metabolic	NOUN
admet-2455	194	24	stress	stress	NOUN
admet-2455	194	25	in	in	ADP
admet-2455	194	26	both	both	CCONJ
admet-2455	194	27	hela	hela	PROPN
admet-2455	194	28	and	and	CCONJ
admet-2455	194	29	scc25	scc25	ADJ
admet-2455	194	30	cells	cell	NOUN
admet-2455	194	31	.	.	PUNCT
admet-2455	195	1	jc1	jc1	PROPN
admet-2455	195	2	staining	stain	VERB
admet-2455	195	3	assays	assay	NOUN
admet-2455	195	4	further	far	ADV
admet-2455	195	5	showed	show	VERB
admet-2455	195	6	mitochondrial	mitochondrial	ADJ
admet-2455	195	7	membrane	membrane	NOUN
admet-2455	195	8	potential	potential	NOUN
admet-2455	195	9	(	(	PUNCT
admet-2455	195	10	mmp	mmp	PROPN
admet-2455	195	11	)	)	PUNCT
admet-2455	195	12	depolarization	depolarization	NOUN
admet-2455	195	13	under	under	ADP
admet-2455	195	14	combination	combination	NOUN
admet-2455	195	15	treatments	treatment	NOUN
admet-2455	195	16	in	in	ADP
admet-2455	195	17	both	both	DET
admet-2455	195	18	cell	cell	NOUN
admet-2455	195	19	lines	line	NOUN
admet-2455	195	20	(	(	PUNCT
admet-2455	195	21	figure	figure	NOUN
admet-2455	195	22	6b	6b	NOUN
admet-2455	195	23	and	and	CCONJ
admet-2455	195	24	6c	6c	NUM
admet-2455	195	25	)	)	PUNCT
admet-2455	195	26	.	.	PUNCT
admet-2455	196	1	next	next	ADV
admet-2455	196	2	,	,	PUNCT
admet-2455	196	3	flow	flow	VERB
admet-2455	196	4	cytometry	cytometry	NOUN
admet-2455	196	5	after	after	SCONJ
admet-2455	196	6	annexin	annexin	NOUN
admet-2455	196	7	-	-	PUNCT
admet-2455	196	8	v	v	NOUN
admet-2455	196	9	/	/	SYM
admet-2455	196	10	pi	pi	NOUN
admet-2455	196	11	dual	dual	ADJ
admet-2455	196	12	staining	staining	NOUN
admet-2455	196	13	revealed	reveal	VERB
admet-2455	196	14	that	that	SCONJ
admet-2455	196	15	the	the	DET
admet-2455	196	16	combination	combination	NOUN
admet-2455	196	17	of	of	ADP
admet-2455	196	18	admet	admet	PROPN
admet-2455	196	19	&	&	CCONJ
admet-2455	196	20	dmpk	dmpk	PROPN
admet-2455	196	21	12(6	12(6	NUM
admet-2455	196	22	)	)	PUNCT
admet-2455	196	23	(	(	PUNCT
admet-2455	196	24	2024	2024	NUM
admet-2455	196	25	)	)	PUNCT
admet-2455	196	26	821	821	NUM
admet-2455	196	27	-	-	SYM
admet-2455	196	28	841	841	NUM
admet-2455	196	29	targeting	targeting	NOUN
admet-2455	196	30	hexokinase	hexokinase	NOUN
admet-2455	196	31	2	2	NUM
admet-2455	196	32	to	to	PART
admet-2455	196	33	enhance	enhance	VERB
admet-2455	196	34	anticancer	anticancer	NOUN
admet-2455	196	35	efficacy	efficacy	NOUN
admet-2455	196	36	of	of	ADP
admet-2455	196	37	trichosanthin	trichosanthin	PROPN
admet-2455	196	38	doi	doi	PROPN
admet-2455	196	39	:	:	PUNCT
admet-2455	196	40	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	INTJ
admet-2455	196	41	831	831	NUM
admet-2455	196	42	tcs	tcs	NOUN
admet-2455	196	43	and	and	CCONJ
admet-2455	196	44	benz	benz	PROPN
admet-2455	196	45	induced	induce	VERB
admet-2455	196	46	markedly	markedly	ADV
admet-2455	196	47	early	early	ADJ
admet-2455	196	48	and	and	CCONJ
admet-2455	196	49	late	late	ADJ
admet-2455	196	50	apoptosis	apoptosis	NOUN
admet-2455	196	51	in	in	ADP
admet-2455	196	52	both	both	DET
admet-2455	196	53	cells	cell	NOUN
admet-2455	196	54	,	,	PUNCT
admet-2455	196	55	as	as	SCONJ
admet-2455	196	56	compared	compare	VERB
admet-2455	196	57	with	with	ADP
admet-2455	196	58	single	single	ADJ
admet-2455	196	59	compound	compound	NOUN
admet-2455	196	60	treatment	treatment	NOUN
admet-2455	196	61	(	(	PUNCT
admet-2455	196	62	figures	figure	NOUN
admet-2455	196	63	6d	6d	NUM
admet-2455	196	64	and	and	CCONJ
admet-2455	196	65	6e	6e	NUM
admet-2455	196	66	)	)	PUNCT
admet-2455	196	67	.	.	PUNCT
admet-2455	197	1	furthermore	furthermore	ADV
admet-2455	197	2	,	,	PUNCT
admet-2455	197	3	significant	significant	ADJ
admet-2455	197	4	increase	increase	NOUN
admet-2455	197	5	of	of	ADP
admet-2455	197	6	pro	pro	ADJ
admet-2455	197	7	-	-	ADJ
admet-2455	197	8	apoptotic	apoptotic	ADJ
admet-2455	197	9	protein	protein	NOUN
admet-2455	197	10	,	,	PUNCT
admet-2455	197	11	cleaved	cleaved	ADJ
admet-2455	197	12	caspase	caspase	NOUN
admet-2455	197	13	3	3	NUM
admet-2455	197	14	(	(	PUNCT
admet-2455	197	15	c	c	NOUN
admet-2455	197	16	-	-	PUNCT
admet-2455	197	17	cas3	cas3	NOUN
admet-2455	197	18	)	)	PUNCT
admet-2455	197	19	,	,	PUNCT
admet-2455	197	20	and	and	CCONJ
admet-2455	197	21	distinctively	distinctively	ADV
admet-2455	197	22	elevated	elevated	ADJ
admet-2455	197	23	ratio	ratio	NOUN
admet-2455	197	24	of	of	ADP
admet-2455	197	25	c	c	NOUN
admet-2455	197	26	-	-	PUNCT
admet-2455	197	27	cas3	cas3	ADJ
admet-2455	197	28	/	/	SYM
admet-2455	197	29	cas3	cas3	PROPN
admet-2455	197	30	were	be	AUX
admet-2455	197	31	detected	detect	VERB
admet-2455	197	32	via	via	ADP
admet-2455	197	33	western	western	ADJ
admet-2455	197	34	blotting	blotting	NOUN
admet-2455	197	35	under	under	ADP
admet-2455	197	36	this	this	DET
admet-2455	197	37	combination	combination	NOUN
admet-2455	197	38	treatment	treatment	NOUN
admet-2455	197	39	in	in	ADP
admet-2455	197	40	both	both	CCONJ
admet-2455	197	41	hela	hela	PROPN
admet-2455	197	42	and	and	CCONJ
admet-2455	197	43	scc25	scc25	PROPN
admet-2455	197	44	cells	cell	NOUN
admet-2455	197	45	,	,	PUNCT
admet-2455	197	46	indicating	indicate	VERB
admet-2455	197	47	apoptosis	apoptosis	NOUN
admet-2455	197	48	cascades	cascade	NOUN
admet-2455	197	49	stimulation	stimulation	NOUN
admet-2455	197	50	and	and	CCONJ
admet-2455	197	51	enhanced	enhance	VERB
admet-2455	197	52	cell	cell	NOUN
admet-2455	197	53	apoptotic	apoptotic	ADJ
admet-2455	197	54	activities	activity	NOUN
admet-2455	197	55	(	(	PUNCT
admet-2455	197	56	figure	figure	NOUN
admet-2455	197	57	6f	6f	NUM
admet-2455	197	58	and	and	CCONJ
admet-2455	197	59	6	6	NUM
admet-2455	197	60	g	g	NOUN
admet-2455	197	61	)	)	PUNCT
admet-2455	197	62	.	.	PUNCT
admet-2455	198	1	figure	figure	VERB
admet-2455	198	2	4	4	NUM
admet-2455	198	3	.	.	PUNCT
admet-2455	198	4	lactate	lactate	NOUN
admet-2455	198	5	secretion	secretion	NOUN
admet-2455	198	6	and	and	CCONJ
admet-2455	198	7	colony	colony	NOUN
admet-2455	198	8	formation	formation	NOUN
admet-2455	198	9	in	in	ADP
admet-2455	198	10	hela	hela	PROPN
admet-2455	198	11	and	and	CCONJ
admet-2455	198	12	scc25	scc25	PROPN
admet-2455	198	13	cell	cell	NOUN
admet-2455	198	14	models	model	NOUN
admet-2455	198	15	.	.	PUNCT
admet-2455	199	1	(	(	PUNCT
admet-2455	199	2	a	a	DET
admet-2455	199	3	,	,	PUNCT
admet-2455	199	4	b	b	NOUN
admet-2455	199	5	)	)	PUNCT
admet-2455	199	6	quantification	quantification	NOUN
admet-2455	199	7	of	of	ADP
admet-2455	199	8	extracellular	extracellular	ADJ
admet-2455	199	9	lactate	lactate	NOUN
admet-2455	199	10	level	level	NOUN
admet-2455	199	11	after	after	ADP
admet-2455	199	12	24	24	NUM
admet-2455	199	13	h	h	NOUN
admet-2455	199	14	treatment	treatment	NOUN
admet-2455	199	15	.	.	PUNCT
admet-2455	200	1	hela	hela	PROPN
admet-2455	200	2	cells	cell	NOUN
admet-2455	200	3	were	be	AUX
admet-2455	200	4	treated	treat	VERB
admet-2455	200	5	with	with	ADP
admet-2455	200	6	50	50	NUM
admet-2455	200	7	μg	μg	NOUN
admet-2455	200	8	/	/	SYM
admet-2455	200	9	ml	ml	NOUN
admet-2455	200	10	tcs	tcs	NOUN
admet-2455	200	11	and	and	CCONJ
admet-2455	200	12	50	50	NUM
admet-2455	200	13	μm	μm	NOUN
admet-2455	200	14	benz	benz	PROPN
admet-2455	200	15	,	,	PUNCT
admet-2455	200	16	alone	alone	ADJ
admet-2455	200	17	or	or	CCONJ
admet-2455	200	18	in	in	ADP
admet-2455	200	19	combined	combine	VERB
admet-2455	200	20	.	.	PUNCT
admet-2455	201	1	scc25	scc25	PROPN
admet-2455	201	2	cells	cell	NOUN
admet-2455	201	3	were	be	AUX
admet-2455	201	4	treated	treat	VERB
admet-2455	201	5	with	with	ADP
admet-2455	201	6	25	25	NUM
admet-2455	201	7	μg	μg	PROPN
admet-2455	201	8	/	/	SYM
admet-2455	201	9	ml	ml	NOUN
admet-2455	201	10	tcs	tcs	NOUN
admet-2455	201	11	and	and	CCONJ
admet-2455	201	12	25	25	NUM
admet-2455	201	13	μm	μm	NUM
admet-2455	201	14	benz	benz	PROPN
admet-2455	201	15	,	,	PUNCT
admet-2455	201	16	alone	alone	ADJ
admet-2455	201	17	or	or	CCONJ
admet-2455	201	18	in	in	ADP
admet-2455	201	19	combined	combine	VERB
admet-2455	201	20	.	.	PUNCT
admet-2455	202	1	(	(	PUNCT
admet-2455	202	2	c	c	X
admet-2455	202	3	,	,	PUNCT
admet-2455	202	4	d	d	NOUN
admet-2455	202	5	)	)	PUNCT
admet-2455	202	6	colony	colony	NOUN
admet-2455	202	7	formation	formation	NOUN
admet-2455	202	8	and	and	CCONJ
admet-2455	202	9	quantification	quantification	NOUN
admet-2455	202	10	results	result	NOUN
admet-2455	202	11	.	.	PUNCT
admet-2455	203	1	hela	hela	PROPN
admet-2455	203	2	cells	cell	NOUN
admet-2455	203	3	were	be	AUX
admet-2455	203	4	treated	treat	VERB
admet-2455	203	5	with	with	ADP
admet-2455	203	6	12.50	12.50	NUM
admet-2455	203	7	μg	μg	NOUN
admet-2455	203	8	/	/	SYM
admet-2455	203	9	ml	ml	NOUN
admet-2455	203	10	tcs	tcs	NOUN
admet-2455	203	11	and	and	CCONJ
admet-2455	203	12	5	5	NUM
admet-2455	203	13	μm	μm	NUM
admet-2455	203	14	benz	benz	PROPN
admet-2455	203	15	,	,	PUNCT
admet-2455	203	16	alone	alone	ADJ
admet-2455	203	17	or	or	CCONJ
admet-2455	203	18	in	in	ADP
admet-2455	203	19	combined	combine	VERB
admet-2455	203	20	.	.	PUNCT
admet-2455	204	1	scc25	scc25	PROPN
admet-2455	204	2	cells	cell	NOUN
admet-2455	204	3	were	be	AUX
admet-2455	204	4	treated	treat	VERB
admet-2455	204	5	with	with	ADP
admet-2455	204	6	6.25	6.25	NUM
admet-2455	204	7	μg	μg	NOUN
admet-2455	204	8	/	/	SYM
admet-2455	204	9	ml	ml	NOUN
admet-2455	204	10	tcs	tcs	NOUN
admet-2455	204	11	and	and	CCONJ
admet-2455	204	12	2.5	2.5	NUM
admet-2455	204	13	μm	μm	NOUN
admet-2455	204	14	benz	benz	PROPN
admet-2455	204	15	,	,	PUNCT
admet-2455	204	16	alone	alone	ADJ
admet-2455	204	17	or	or	CCONJ
admet-2455	204	18	in	in	ADP
admet-2455	204	19	combined	combine	VERB
admet-2455	204	20	.	.	PUNCT
admet-2455	205	1	after	after	ADP
admet-2455	205	2	72	72	NUM
admet-2455	205	3	h	h	NOUN
admet-2455	205	4	drug	drug	NOUN
admet-2455	205	5	exposure	exposure	NOUN
admet-2455	205	6	,	,	PUNCT
admet-2455	205	7	cells	cell	NOUN
admet-2455	205	8	were	be	AUX
admet-2455	205	9	maintained	maintain	VERB
admet-2455	205	10	in	in	ADP
admet-2455	205	11	drug	drug	NOUN
admet-2455	205	12	-	-	PUNCT
admet-2455	205	13	free	free	ADJ
admet-2455	205	14	culture	culture	NOUN
admet-2455	205	15	medium	medium	NOUN
admet-2455	205	16	to	to	PART
admet-2455	205	17	form	form	VERB
admet-2455	205	18	colonies	colony	NOUN
admet-2455	205	19	.	.	PUNCT
admet-2455	206	1	data	datum	NOUN
admet-2455	206	2	were	be	AUX
admet-2455	206	3	presented	present	VERB
admet-2455	206	4	as	as	ADP
admet-2455	206	5	mean	mean	NOUN
admet-2455	206	6	±	±	NUM
admet-2455	206	7	se	se	X
admet-2455	206	8	(	(	PUNCT
admet-2455	206	9	n	n	NOUN
admet-2455	206	10	=	=	SYM
admet-2455	206	11	3	3	NUM
admet-2455	206	12	)	)	PUNCT
admet-2455	206	13	;	;	PUNCT
admet-2455	206	14	ns	ns	NUM
admet-2455	206	15	indicates	indicate	VERB
admet-2455	206	16	non	non	ADJ
admet-2455	206	17	-	-	ADJ
admet-2455	206	18	significant	significant	ADJ
admet-2455	206	19	,	,	PUNCT
admet-2455	206	20	*	*	PUNCT
admet-2455	206	21	represents	represent	VERB
admet-2455	206	22	p	p	PRON
admet-2455	206	23	<	<	X
admet-2455	206	24	0.05	0.05	NUM
admet-2455	206	25	,	,	PUNCT
admet-2455	206	26	*	*	PUNCT
admet-2455	206	27	*	*	PUNCT
admet-2455	206	28	represents	represent	VERB
admet-2455	206	29	p<0.01	p<0.01	PROPN
admet-2455	206	30	,	,	PUNCT
admet-2455	206	31	*	*	PUNCT
admet-2455	206	32	*	*	PUNCT
admet-2455	206	33	*	*	PUNCT
admet-2455	206	34	represents	represent	VERB
admet-2455	206	35	p<0.001	p<0.001	VERB
admet-2455	206	36	,	,	PUNCT
admet-2455	206	37	*	*	PUNCT
admet-2455	206	38	*	*	PUNCT
admet-2455	206	39	*	*	PUNCT
admet-2455	206	40	*	*	PUNCT
admet-2455	206	41	represents	represent	VERB
admet-2455	206	42	p	p	PRON
admet-2455	206	43	<	<	X
admet-2455	206	44	0.0001	0.0001	NUM
admet-2455	206	45	.	.	PUNCT
admet-2455	207	1	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PROPN
admet-2455	207	2	y.	y.	PROPN
admet-2455	207	3	zhou	zhou	PROPN
admet-2455	207	4	et	et	PROPN
admet-2455	207	5	al	al	PROPN
admet-2455	207	6	.	.	PROPN
admet-2455	207	7	admet	admet	PROPN
admet-2455	207	8	&	&	CCONJ
admet-2455	207	9	dmpk	dmpk	PROPN
admet-2455	207	10	12(6	12(6	NUM
admet-2455	207	11	)	)	PUNCT
admet-2455	207	12	(	(	PUNCT
admet-2455	207	13	2024	2024	NUM
admet-2455	207	14	)	)	PUNCT
admet-2455	207	15	821	821	NUM
admet-2455	207	16	-	-	SYM
admet-2455	207	17	841	841	NUM
admet-2455	207	18	832	832	NUM
admet-2455	207	19	figure	figure	NOUN
admet-2455	207	20	5	5	NUM
admet-2455	207	21	.	.	PUNCT
admet-2455	207	22	cell	cell	NOUN
admet-2455	207	23	cycle	cycle	NOUN
admet-2455	207	24	analysis	analysis	NOUN
admet-2455	207	25	after	after	ADP
admet-2455	207	26	24	24	NUM
admet-2455	207	27	h	h	NOUN
admet-2455	207	28	of	of	ADP
admet-2455	207	29	treatment	treatment	NOUN
admet-2455	207	30	.	.	PUNCT
admet-2455	208	1	hela	hela	PROPN
admet-2455	208	2	cells	cell	NOUN
admet-2455	208	3	were	be	AUX
admet-2455	208	4	treated	treat	VERB
admet-2455	208	5	with	with	ADP
admet-2455	208	6	25	25	NUM
admet-2455	208	7	μg	μg	PROPN
admet-2455	208	8	/	/	SYM
admet-2455	208	9	ml	ml	NOUN
admet-2455	208	10	tcs	tcs	NOUN
admet-2455	208	11	and	and	CCONJ
admet-2455	208	12	25	25	NUM
admet-2455	208	13	μm	μm	NUM
admet-2455	208	14	benz	benz	PROPN
admet-2455	208	15	,	,	PUNCT
admet-2455	208	16	either	either	CCONJ
admet-2455	208	17	alone	alone	ADJ
admet-2455	208	18	or	or	CCONJ
admet-2455	208	19	in	in	ADP
admet-2455	208	20	combination	combination	NOUN
admet-2455	208	21	.	.	PUNCT
admet-2455	209	1	scc25	scc25	ADJ
admet-2455	209	2	cells	cell	NOUN
admet-2455	209	3	were	be	AUX
admet-2455	209	4	treated	treat	VERB
admet-2455	209	5	with	with	ADP
admet-2455	209	6	12.5	12.5	NUM
admet-2455	209	7	μg	μg	NOUN
admet-2455	209	8	/	/	SYM
admet-2455	209	9	ml	ml	NOUN
admet-2455	209	10	tcs	tcs	NOUN
admet-2455	209	11	and	and	CCONJ
admet-2455	209	12	12.5	12.5	NUM
admet-2455	209	13	μm	μm	NOUN
admet-2455	209	14	benz	benz	PROPN
admet-2455	209	15	,	,	PUNCT
admet-2455	209	16	either	either	CCONJ
admet-2455	209	17	alone	alone	ADJ
admet-2455	209	18	or	or	CCONJ
admet-2455	209	19	in	in	ADP
admet-2455	209	20	combination	combination	NOUN
admet-2455	209	21	.	.	PUNCT
admet-2455	210	1	(	(	PUNCT
admet-2455	210	2	a	a	X
admet-2455	210	3	)	)	PUNCT
admet-2455	210	4	flow	flow	NOUN
admet-2455	210	5	cytometry	cytometry	NOUN
admet-2455	210	6	results	result	NOUN
admet-2455	210	7	showing	show	VERB
admet-2455	210	8	cell	cell	NOUN
admet-2455	210	9	cycle	cycle	NOUN
admet-2455	210	10	distribution	distribution	NOUN
admet-2455	210	11	in	in	ADP
admet-2455	210	12	hela	hela	ADJ
admet-2455	210	13	cells	cell	NOUN
admet-2455	210	14	.	.	PUNCT
admet-2455	211	1	(	(	PUNCT
admet-2455	211	2	b	b	X
admet-2455	211	3	)	)	PUNCT
admet-2455	211	4	the	the	DET
admet-2455	211	5	cell	cell	NOUN
admet-2455	211	6	percentage	percentage	NOUN
admet-2455	211	7	of	of	ADP
admet-2455	211	8	g0	g0	PROPN
admet-2455	211	9	/	/	SYM
admet-2455	211	10	g1	g1	PROPN
admet-2455	211	11	,	,	PUNCT
admet-2455	211	12	s	s	PART
admet-2455	211	13	and	and	CCONJ
admet-2455	211	14	g2	g2	PROPN
admet-2455	211	15	-	-	PUNCT
admet-2455	211	16	m	m	PROPN
admet-2455	211	17	phases	phase	NOUN
admet-2455	211	18	were	be	AUX
admet-2455	211	19	quantified	quantify	VERB
admet-2455	211	20	and	and	CCONJ
admet-2455	211	21	plotted	plot	VERB
admet-2455	211	22	as	as	ADP
admet-2455	211	23	histogram	histogram	NOUN
admet-2455	211	24	in	in	ADP
admet-2455	211	25	hela	hela	ADJ
admet-2455	211	26	cells	cell	NOUN
admet-2455	211	27	.	.	PUNCT
admet-2455	212	1	(	(	PUNCT
admet-2455	212	2	c	c	X
admet-2455	212	3	)	)	PUNCT
admet-2455	212	4	flow	flow	NOUN
admet-2455	212	5	cytometry	cytometry	NOUN
admet-2455	212	6	results	result	NOUN
admet-2455	212	7	depicting	depict	VERB
admet-2455	212	8	cell	cell	NOUN
admet-2455	212	9	cycle	cycle	NOUN
admet-2455	212	10	distribution	distribution	NOUN
admet-2455	212	11	in	in	ADP
admet-2455	212	12	scc25	scc25	ADJ
admet-2455	212	13	cells	cell	NOUN
admet-2455	212	14	.	.	PUNCT
admet-2455	213	1	(	(	PUNCT
admet-2455	213	2	d	d	X
admet-2455	213	3	)	)	PUNCT
admet-2455	213	4	quantification	quantification	NOUN
admet-2455	213	5	of	of	ADP
admet-2455	213	6	cell	cell	NOUN
admet-2455	213	7	cycle	cycle	NOUN
admet-2455	213	8	distribution	distribution	NOUN
admet-2455	213	9	in	in	ADP
admet-2455	213	10	scc25	scc25	ADJ
admet-2455	213	11	cells	cell	NOUN
admet-2455	213	12	.	.	PUNCT
admet-2455	214	1	results	result	NOUN
admet-2455	214	2	were	be	AUX
admet-2455	214	3	presented	present	VERB
admet-2455	214	4	as	as	ADP
admet-2455	214	5	mean	mean	NOUN
admet-2455	214	6	±	±	NUM
admet-2455	214	7	se	se	X
admet-2455	214	8	(	(	PUNCT
admet-2455	214	9	n	n	NOUN
admet-2455	214	10	=	=	SYM
admet-2455	214	11	3	3	NUM
admet-2455	214	12	)	)	PUNCT
admet-2455	214	13	;	;	PUNCT
admet-2455	214	14	ns	ns	NUM
admet-2455	214	15	indicates	indicate	VERB
admet-2455	214	16	non	non	ADJ
admet-2455	214	17	-	-	ADJ
admet-2455	214	18	significant	significant	ADJ
admet-2455	214	19	,	,	PUNCT
admet-2455	214	20	*	*	PUNCT
admet-2455	214	21	represents	represent	VERB
admet-2455	214	22	p	p	PRON
admet-2455	214	23	<	<	X
admet-2455	214	24	0.05	0.05	NUM
admet-2455	214	25	,	,	PUNCT
admet-2455	214	26	*	*	PUNCT
admet-2455	214	27	*	*	PUNCT
admet-2455	214	28	*	*	PUNCT
admet-2455	214	29	represents	represent	VERB
admet-2455	214	30	p<0.001	p<0.001	VERB
admet-2455	214	31	,	,	PUNCT
admet-2455	214	32	*	*	PUNCT
admet-2455	214	33	*	*	PUNCT
admet-2455	214	34	*	*	PUNCT
admet-2455	214	35	*	*	PUNCT
admet-2455	214	36	represents	represent	VERB
admet-2455	214	37	p	p	PRON
admet-2455	214	38	<	<	X
admet-2455	214	39	0.0001	0.0001	NUM
admet-2455	214	40	.	.	PUNCT
admet-2455	215	1	admet	admet	PROPN
admet-2455	215	2	&	&	CCONJ
admet-2455	215	3	dmpk	dmpk	PROPN
admet-2455	215	4	12(6	12(6	NUM
admet-2455	215	5	)	)	PUNCT
admet-2455	215	6	(	(	PUNCT
admet-2455	215	7	2024	2024	NUM
admet-2455	215	8	)	)	PUNCT
admet-2455	215	9	821	821	NUM
admet-2455	215	10	-	-	SYM
admet-2455	215	11	841	841	NUM
admet-2455	215	12	targeting	targeting	NOUN
admet-2455	215	13	hexokinase	hexokinase	NOUN
admet-2455	215	14	2	2	NUM
admet-2455	215	15	to	to	PART
admet-2455	215	16	enhance	enhance	VERB
admet-2455	215	17	anticancer	anticancer	NOUN
admet-2455	215	18	efficacy	efficacy	NOUN
admet-2455	215	19	of	of	ADP
admet-2455	215	20	trichosanthin	trichosanthin	PROPN
admet-2455	215	21	doi	doi	PROPN
admet-2455	215	22	:	:	PUNCT
admet-2455	215	23	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	ADJ
admet-2455	215	24	833	833	NUM
admet-2455	215	25	figure	figure	NOUN
admet-2455	215	26	6	6	NUM
admet-2455	215	27	.	.	PUNCT
admet-2455	215	28	cellular	cellular	ADJ
admet-2455	215	29	ros	ros	PROPN
admet-2455	215	30	,	,	PUNCT
admet-2455	215	31	mitochondrial	mitochondrial	ADJ
admet-2455	215	32	membrane	membrane	NOUN
admet-2455	215	33	potential	potential	NOUN
admet-2455	215	34	(	(	PUNCT
admet-2455	215	35	mmp	mmp	PROPN
admet-2455	215	36	)	)	PUNCT
admet-2455	215	37	,	,	PUNCT
admet-2455	215	38	and	and	CCONJ
admet-2455	215	39	apoptosis	apoptosis	NOUN
admet-2455	215	40	in	in	ADP
admet-2455	215	41	hela	hela	PROPN
admet-2455	215	42	and	and	CCONJ
admet-2455	215	43	scc25	scc25	PROPN
admet-2455	215	44	cell	cell	NOUN
admet-2455	215	45	models	model	NOUN
admet-2455	215	46	.	.	PUNCT
admet-2455	216	1	hela	hela	PROPN
admet-2455	216	2	cells	cell	NOUN
admet-2455	216	3	were	be	AUX
admet-2455	216	4	treated	treat	VERB
admet-2455	216	5	with	with	ADP
admet-2455	216	6	25	25	NUM
admet-2455	216	7	μg	μg	PROPN
admet-2455	216	8	/	/	SYM
admet-2455	216	9	ml	ml	NOUN
admet-2455	216	10	tcs	tcs	NOUN
admet-2455	216	11	and	and	CCONJ
admet-2455	216	12	25	25	NUM
admet-2455	216	13	μm	μm	NUM
admet-2455	216	14	benz	benz	PROPN
admet-2455	216	15	,	,	PUNCT
admet-2455	216	16	alone	alone	ADJ
admet-2455	216	17	or	or	CCONJ
admet-2455	216	18	in	in	ADP
admet-2455	216	19	combined	combine	VERB
admet-2455	216	20	.	.	PUNCT
admet-2455	217	1	scc25	scc25	PROPN
admet-2455	217	2	cells	cell	NOUN
admet-2455	217	3	were	be	AUX
admet-2455	217	4	treated	treat	VERB
admet-2455	217	5	with	with	ADP
admet-2455	217	6	12.5	12.5	NUM
admet-2455	217	7	μg	μg	NOUN
admet-2455	217	8	/	/	SYM
admet-2455	217	9	ml	ml	NOUN
admet-2455	217	10	tcs	tcs	NOUN
admet-2455	217	11	and	and	CCONJ
admet-2455	217	12	12.5	12.5	NUM
admet-2455	217	13	μm	μm	NOUN
admet-2455	217	14	benz	benz	PROPN
admet-2455	217	15	,	,	PUNCT
admet-2455	217	16	alone	alone	ADJ
admet-2455	217	17	or	or	CCONJ
admet-2455	217	18	in	in	ADP
admet-2455	217	19	combined	combine	VERB
admet-2455	217	20	.	.	PUNCT
admet-2455	218	1	(	(	PUNCT
admet-2455	218	2	a	a	X
admet-2455	218	3	)	)	PUNCT
admet-2455	218	4	cellular	cellular	ADJ
admet-2455	218	5	ros	ros	PROPN
admet-2455	218	6	amounts	amount	NOUN
admet-2455	218	7	were	be	AUX
admet-2455	218	8	measured	measure	VERB
admet-2455	218	9	in	in	ADP
admet-2455	218	10	both	both	DET
admet-2455	218	11	cell	cell	NOUN
admet-2455	218	12	lines	line	NOUN
admet-2455	218	13	after	after	ADP
admet-2455	218	14	4	4	NUM
admet-2455	218	15	h	h	NOUN
admet-2455	218	16	drug	drug	NOUN
admet-2455	218	17	treatment	treatment	NOUN
admet-2455	218	18	.	.	PUNCT
admet-2455	219	1	(	(	PUNCT
admet-2455	219	2	b	b	X
admet-2455	219	3	)	)	PUNCT
admet-2455	219	4	cells	cell	NOUN
admet-2455	219	5	were	be	AUX
admet-2455	219	6	exposed	expose	VERB
admet-2455	219	7	to	to	ADP
admet-2455	219	8	24	24	NUM
admet-2455	219	9	h	h	NOUN
admet-2455	219	10	treatment	treatment	NOUN
admet-2455	219	11	,	,	PUNCT
admet-2455	219	12	followed	follow	VERB
admet-2455	219	13	by	by	ADP
admet-2455	219	14	flow	flow	NOUN
admet-2455	219	15	cytometry	cytometry	NOUN
admet-2455	219	16	assay	assay	VERB
admet-2455	219	17	to	to	PART
admet-2455	219	18	detect	detect	VERB
admet-2455	219	19	the	the	DET
admet-2455	219	20	mmp	mmp	PROPN
admet-2455	219	21	changes	change	NOUN
admet-2455	219	22	which	which	PRON
admet-2455	219	23	were	be	AUX
admet-2455	219	24	indicated	indicate	VERB
admet-2455	219	25	by	by	ADP
admet-2455	219	26	the	the	DET
admet-2455	219	27	ratio	ratio	NOUN
admet-2455	219	28	of	of	ADP
admet-2455	219	29	jc-1	jc-1	NOUN
admet-2455	219	30	aggregate	aggregate	NOUN
admet-2455	219	31	(	(	PUNCT
admet-2455	219	32	pered)/jc-1	pered)/jc-1	NOUN
admet-2455	219	33	monomer	monomer	NOUN
admet-2455	219	34	(	(	PUNCT
admet-2455	219	35	fitc	fitc	NOUN
admet-2455	219	36	-	-	PUNCT
admet-2455	219	37	green	green	ADJ
admet-2455	219	38	)	)	PUNCT
admet-2455	219	39	fluorescence	fluorescence	NOUN
admet-2455	219	40	signal	signal	NOUN
admet-2455	219	41	.	.	PUNCT
admet-2455	220	1	(	(	PUNCT
admet-2455	220	2	c	c	X
admet-2455	220	3	)	)	PUNCT
admet-2455	220	4	quantification	quantification	NOUN
admet-2455	220	5	results	result	NOUN
admet-2455	220	6	of	of	ADP
admet-2455	220	7	mmp	mmp	PROPN
admet-2455	220	8	.	.	PUNCT
admet-2455	221	1	(	(	PUNCT
admet-2455	221	2	d	d	X
admet-2455	221	3	)	)	PUNCT
admet-2455	221	4	flow	flow	NOUN
admet-2455	221	5	cytometry	cytometry	NOUN
admet-2455	221	6	to	to	PART
admet-2455	221	7	determine	determine	VERB
admet-2455	221	8	the	the	DET
admet-2455	221	9	percentage	percentage	NOUN
admet-2455	221	10	of	of	ADP
admet-2455	221	11	apoptotic	apoptotic	ADJ
admet-2455	221	12	cells	cell	NOUN
admet-2455	221	13	after	after	ADP
admet-2455	221	14	24	24	NUM
admet-2455	221	15	h	h	NOUN
admet-2455	221	16	treatment	treatment	NOUN
admet-2455	221	17	.	.	PUNCT
admet-2455	222	1	late	late	ADJ
admet-2455	222	2	apoptotic	apoptotic	ADJ
admet-2455	222	3	cells	cell	NOUN
admet-2455	222	4	are	be	AUX
admet-2455	222	5	shown	show	VERB
admet-2455	222	6	in	in	ADP
admet-2455	222	7	the	the	DET
admet-2455	222	8	upper	upper	ADJ
admet-2455	222	9	right	right	NOUN
admet-2455	222	10	quadrant	quadrant	NOUN
admet-2455	222	11	,	,	PUNCT
admet-2455	222	12	and	and	CCONJ
admet-2455	222	13	early	early	ADJ
admet-2455	222	14	apoptotic	apoptotic	ADJ
admet-2455	222	15	cells	cell	NOUN
admet-2455	222	16	are	be	AUX
admet-2455	222	17	shown	show	VERB
admet-2455	222	18	in	in	ADP
admet-2455	222	19	the	the	DET
admet-2455	222	20	lower	low	ADJ
admet-2455	222	21	right	right	ADJ
admet-2455	222	22	quadrant	quadrant	NOUN
admet-2455	222	23	.	.	PUNCT
admet-2455	223	1	(	(	PUNCT
admet-2455	223	2	e	e	X
admet-2455	223	3	)	)	PUNCT
admet-2455	223	4	quantification	quantification	NOUN
admet-2455	223	5	results	result	NOUN
admet-2455	223	6	of	of	ADP
admet-2455	223	7	cell	cell	NOUN
admet-2455	223	8	apoptosis	apoptosis	NOUN
admet-2455	223	9	percentage	percentage	NOUN
admet-2455	223	10	.	.	PUNCT
admet-2455	224	1	(	(	PUNCT
admet-2455	224	2	f	f	X
admet-2455	224	3	,	,	PUNCT
admet-2455	224	4	g	g	NOUN
admet-2455	224	5	)	)	PUNCT
admet-2455	224	6	western	western	ADJ
admet-2455	224	7	blotting	blot	VERB
admet-2455	224	8	to	to	PART
admet-2455	224	9	detect	detect	VERB
admet-2455	224	10	apoptotic	apoptotic	ADJ
admet-2455	224	11	protein	protein	NOUN
admet-2455	224	12	caspase	caspase	NOUN
admet-2455	224	13	3	3	NUM
admet-2455	224	14	(	(	PUNCT
admet-2455	224	15	cas3	cas3	PROPN
admet-2455	224	16	)	)	PUNCT
admet-2455	224	17	and	and	CCONJ
admet-2455	224	18	its	its	PRON
admet-2455	224	19	cleavage	cleavage	NOUN
admet-2455	224	20	in	in	ADP
admet-2455	224	21	hela	hela	PROPN
admet-2455	224	22	and	and	CCONJ
admet-2455	224	23	scc25	scc25	PROPN
admet-2455	224	24	cells	cell	NOUN
admet-2455	224	25	.	.	PUNCT
admet-2455	225	1	data	datum	NOUN
admet-2455	225	2	were	be	AUX
admet-2455	225	3	presented	present	VERB
admet-2455	225	4	as	as	ADP
admet-2455	225	5	mean	mean	NOUN
admet-2455	225	6	±	±	NUM
admet-2455	225	7	se	se	X
admet-2455	225	8	(	(	PUNCT
admet-2455	225	9	n	n	NOUN
admet-2455	225	10	=	=	SYM
admet-2455	225	11	3	3	NUM
admet-2455	225	12	)	)	PUNCT
admet-2455	225	13	;	;	PUNCT
admet-2455	225	14	ns	ns	NUM
admet-2455	225	15	indicates	indicate	VERB
admet-2455	225	16	non	non	ADJ
admet-2455	225	17	-	-	ADJ
admet-2455	225	18	significant	significant	ADJ
admet-2455	225	19	,	,	PUNCT
admet-2455	225	20	*	*	PUNCT
admet-2455	225	21	represents	represent	VERB
admet-2455	225	22	p	p	PRON
admet-2455	225	23	<	<	X
admet-2455	225	24	0.05	0.05	NUM
admet-2455	225	25	,	,	PUNCT
admet-2455	225	26	*	*	PUNCT
admet-2455	225	27	*	*	PUNCT
admet-2455	225	28	represents	represent	VERB
admet-2455	225	29	p<0.01	p<0.01	PROPN
admet-2455	225	30	,	,	PUNCT
admet-2455	225	31	*	*	PUNCT
admet-2455	225	32	*	*	PUNCT
admet-2455	225	33	*	*	PUNCT
admet-2455	225	34	*	*	PUNCT
admet-2455	225	35	represents	represent	VERB
admet-2455	225	36	p	p	PRON
admet-2455	225	37	<	<	X
admet-2455	225	38	0.0001	0.0001	NUM
admet-2455	225	39	.	.	PUNCT
admet-2455	226	1	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PROPN
admet-2455	226	2	y.	y.	PROPN
admet-2455	226	3	zhou	zhou	PROPN
admet-2455	226	4	et	et	PROPN
admet-2455	226	5	al	al	PROPN
admet-2455	226	6	.	.	PROPN
admet-2455	226	7	admet	admet	PROPN
admet-2455	226	8	&	&	CCONJ
admet-2455	226	9	dmpk	dmpk	PROPN
admet-2455	226	10	12(6	12(6	NUM
admet-2455	226	11	)	)	PUNCT
admet-2455	226	12	(	(	PUNCT
admet-2455	226	13	2024	2024	NUM
admet-2455	226	14	)	)	PUNCT
admet-2455	226	15	821	821	NUM
admet-2455	226	16	-	-	SYM
admet-2455	226	17	841	841	NUM
admet-2455	226	18	834	834	NUM
admet-2455	226	19	tcs	tcs	NOUN
admet-2455	226	20	treatment	treatment	NOUN
admet-2455	226	21	alone	alone	ADV
admet-2455	226	22	induced	induce	VERB
admet-2455	226	23	activation	activation	NOUN
admet-2455	226	24	of	of	ADP
admet-2455	226	25	nf	nf	NOUN
admet-2455	226	26	-	-	PUNCT
admet-2455	226	27	κb	κb	ADJ
admet-2455	226	28	/	/	SYM
admet-2455	226	29	erk	erk	PROPN
admet-2455	226	30	survival	survival	NOUN
admet-2455	226	31	signalling	signal	VERB
admet-2455	226	32	to	to	PART
admet-2455	226	33	investigate	investigate	VERB
admet-2455	226	34	the	the	DET
admet-2455	226	35	transcriptome	transcriptome	ADJ
admet-2455	226	36	changes	change	NOUN
admet-2455	226	37	and	and	CCONJ
admet-2455	226	38	explore	explore	VERB
admet-2455	226	39	the	the	DET
admet-2455	226	40	intricate	intricate	ADJ
admet-2455	226	41	molecular	molecular	ADJ
admet-2455	226	42	mechanisms	mechanism	NOUN
admet-2455	226	43	under	under	ADP
admet-2455	226	44	tcs	tcs	PROPN
admet-2455	226	45	single	single	ADJ
admet-2455	226	46	treatment	treatment	NOUN
admet-2455	226	47	,	,	PUNCT
admet-2455	226	48	rna	rna	NOUN
admet-2455	226	49	-	-	PUNCT
admet-2455	226	50	sequencing	sequence	VERB
admet-2455	226	51	analysis	analysis	NOUN
admet-2455	226	52	was	be	AUX
admet-2455	226	53	performed	perform	VERB
admet-2455	226	54	on	on	ADP
admet-2455	226	55	hela	hela	ADJ
admet-2455	226	56	cells	cell	NOUN
admet-2455	226	57	exposed	expose	VERB
admet-2455	226	58	to	to	ADP
admet-2455	226	59	80	80	NUM
admet-2455	226	60	ng	ng	PROPN
admet-2455	226	61	tcs	tcs	NOUN
admet-2455	226	62	for	for	ADP
admet-2455	226	63	24	24	NUM
admet-2455	226	64	h.	h.	PROPN
admet-2455	226	65	the	the	DET
admet-2455	226	66	kyoto	kyoto	PROPN
admet-2455	226	67	encyclopedia	encyclopedia	NOUN
admet-2455	226	68	of	of	ADP
admet-2455	226	69	genes	gene	NOUN
admet-2455	226	70	and	and	CCONJ
admet-2455	226	71	genomes	genome	NOUN
admet-2455	226	72	(	(	PUNCT
admet-2455	226	73	kegg	kegg	NOUN
admet-2455	226	74	)	)	PUNCT
admet-2455	226	75	enrichment	enrichment	NOUN
admet-2455	226	76	analysis	analysis	NOUN
admet-2455	226	77	showed	show	VERB
admet-2455	226	78	tcs	tcs	NOUN
admet-2455	226	79	treatment	treatment	NOUN
admet-2455	226	80	alone	alone	ADV
admet-2455	226	81	induced	induce	VERB
admet-2455	226	82	apoptosis	apoptosis	NOUN
admet-2455	226	83	and	and	CCONJ
admet-2455	226	84	activation	activation	NOUN
admet-2455	226	85	of	of	ADP
admet-2455	226	86	cancer	cancer	NOUN
admet-2455	226	87	survival	survival	NOUN
admet-2455	226	88	signalling	signal	VERB
admet-2455	226	89	including	include	VERB
admet-2455	226	90	mapk	mapk	NOUN
admet-2455	226	91	and	and	CCONJ
admet-2455	226	92	nf	nf	ADJ
admet-2455	226	93	-	-	PUNCT
admet-2455	226	94	κb	κb	ADJ
admet-2455	226	95	pathways	pathway	NOUN
admet-2455	226	96	(	(	PUNCT
admet-2455	226	97	figure	figure	NOUN
admet-2455	226	98	7a	7a	NUM
admet-2455	226	99	)	)	PUNCT
admet-2455	226	100	.	.	PUNCT
admet-2455	226	101	.	.	PUNCT
admet-2455	227	1	figure	figure	VERB
admet-2455	227	2	7	7	NUM
admet-2455	227	3	.	.	PUNCT
admet-2455	227	4	effect	effect	NOUN
admet-2455	227	5	of	of	ADP
admet-2455	227	6	tcs	tcs	NOUN
admet-2455	227	7	treatment	treatment	NOUN
admet-2455	227	8	alone	alone	ADV
admet-2455	227	9	on	on	ADP
admet-2455	227	10	nf	nf	ADJ
admet-2455	227	11	-	-	PUNCT
admet-2455	227	12	κb	κb	ADJ
admet-2455	227	13	/	/	SYM
admet-2455	227	14	erk	erk	PROPN
admet-2455	227	15	related	relate	VERB
admet-2455	227	16	gene	gene	NOUN
admet-2455	227	17	/	/	SYM
admet-2455	227	18	protein	protein	NOUN
admet-2455	227	19	expressions	expression	NOUN
admet-2455	227	20	.	.	PUNCT
admet-2455	228	1	(	(	PUNCT
admet-2455	228	2	a	a	X
admet-2455	228	3	)	)	PUNCT
admet-2455	228	4	kegg	kegg	NOUN
admet-2455	228	5	enrichment	enrichment	NOUN
admet-2455	228	6	analysis	analysis	NOUN
admet-2455	228	7	of	of	ADP
admet-2455	228	8	rna	rna	NOUN
admet-2455	228	9	-	-	PUNCT
admet-2455	228	10	sequencing	sequence	VERB
admet-2455	228	11	data	datum	NOUN
admet-2455	228	12	in	in	ADP
admet-2455	228	13	hela	hela	ADJ
admet-2455	228	14	cells	cell	NOUN
admet-2455	228	15	with	with	ADP
admet-2455	228	16	80ng	80ng	ADJ
admet-2455	228	17	tcs	tcs	NOUN
admet-2455	228	18	treatment	treatment	NOUN
admet-2455	228	19	for	for	ADP
admet-2455	228	20	24h	24h	NOUN
admet-2455	228	21	.	.	PUNCT
admet-2455	229	1	(	(	PUNCT
admet-2455	229	2	b	b	X
admet-2455	229	3	)	)	PUNCT
admet-2455	229	4	western	western	ADJ
admet-2455	229	5	blot	blot	NOUN
admet-2455	229	6	results	result	NOUN
admet-2455	229	7	of	of	ADP
admet-2455	229	8	nf	nf	NOUN
admet-2455	229	9	-	-	PUNCT
admet-2455	229	10	κb	κb	NOUN
admet-2455	229	11	,	,	PUNCT
admet-2455	229	12	p	p	NOUN
admet-2455	229	13	-	-	PUNCT
admet-2455	229	14	nf	nf	NOUN
admet-2455	229	15	-	-	PUNCT
admet-2455	229	16	κb	κb	NOUN
admet-2455	229	17	,	,	PUNCT
admet-2455	229	18	erk	erk	PROPN
admet-2455	229	19	,	,	PUNCT
admet-2455	229	20	p	p	PROPN
admet-2455	229	21	-	-	PUNCT
admet-2455	229	22	erk	erk	NOUN
admet-2455	229	23	protein	protein	NOUN
admet-2455	229	24	expressions	expression	NOUN
admet-2455	229	25	.	.	PUNCT
admet-2455	230	1	hela	hela	PROPN
admet-2455	230	2	cells	cell	NOUN
admet-2455	230	3	were	be	AUX
admet-2455	230	4	exposed	expose	VERB
admet-2455	230	5	to	to	ADP
admet-2455	230	6	a	a	DET
admet-2455	230	7	serial	serial	NOUN
admet-2455	230	8	of	of	ADP
admet-2455	230	9	tcs	tcs	NOUN
admet-2455	230	10	treatments	treatment	NOUN
admet-2455	230	11	at	at	ADP
admet-2455	230	12	6.25	6.25	NUM
admet-2455	230	13	,	,	PUNCT
admet-2455	230	14	12.5	12.5	NUM
admet-2455	230	15	and	and	CCONJ
admet-2455	230	16	25	25	NUM
admet-2455	230	17	μg	μg	PROPN
admet-2455	230	18	/	/	SYM
admet-2455	230	19	ml	ml	NOUN
admet-2455	230	20	,	,	PUNCT
admet-2455	230	21	respectively	respectively	ADV
admet-2455	230	22	,	,	PUNCT
admet-2455	230	23	for	for	ADP
admet-2455	230	24	24	24	NUM
admet-2455	230	25	h.	h.	NOUN
admet-2455	230	26	(	(	PUNCT
admet-2455	230	27	c	c	NOUN
admet-2455	230	28	)	)	PUNCT
admet-2455	230	29	quantification	quantification	NOUN
admet-2455	230	30	results	result	NOUN
admet-2455	230	31	of	of	ADP
admet-2455	230	32	relative	relative	ADJ
admet-2455	230	33	protein	protein	NOUN
admet-2455	230	34	expression	expression	NOUN
admet-2455	230	35	level	level	NOUN
admet-2455	230	36	in	in	ADP
admet-2455	230	37	hela	hela	ADJ
admet-2455	230	38	cells	cell	NOUN
admet-2455	230	39	.	.	PUNCT
admet-2455	231	1	(	(	PUNCT
admet-2455	231	2	d	d	X
admet-2455	231	3	)	)	PUNCT
admet-2455	231	4	western	western	ADJ
admet-2455	231	5	blot	blot	NOUN
admet-2455	231	6	results	result	NOUN
admet-2455	231	7	of	of	ADP
admet-2455	231	8	nf	nf	NOUN
admet-2455	231	9	-	-	PUNCT
admet-2455	231	10	κb	κb	NOUN
admet-2455	231	11	,	,	PUNCT
admet-2455	231	12	p	p	NOUN
admet-2455	231	13	-	-	PUNCT
admet-2455	231	14	nf	nf	NOUN
admet-2455	231	15	-	-	PUNCT
admet-2455	231	16	κb	κb	NOUN
admet-2455	231	17	,	,	PUNCT
admet-2455	231	18	erk	erk	PROPN
admet-2455	231	19	,	,	PUNCT
admet-2455	231	20	p	p	PROPN
admet-2455	231	21	-	-	PUNCT
admet-2455	231	22	erk	erk	NOUN
admet-2455	231	23	protein	protein	NOUN
admet-2455	231	24	expressions	expression	NOUN
admet-2455	231	25	.	.	PUNCT
admet-2455	232	1	scc25	scc25	ADJ
admet-2455	232	2	cells	cell	NOUN
admet-2455	232	3	were	be	AUX
admet-2455	232	4	exposed	expose	VERB
admet-2455	232	5	to	to	ADP
admet-2455	232	6	a	a	DET
admet-2455	232	7	serial	serial	NOUN
admet-2455	232	8	of	of	ADP
admet-2455	232	9	tcs	tcs	NOUN
admet-2455	232	10	treatments	treatment	NOUN
admet-2455	232	11	at	at	ADP
admet-2455	232	12	3.13	3.13	NUM
admet-2455	232	13	,	,	PUNCT
admet-2455	232	14	6.25	6.25	NUM
admet-2455	232	15	and	and	CCONJ
admet-2455	232	16	12.5	12.5	NUM
admet-2455	232	17	μg	μg	NOUN
admet-2455	232	18	/	/	SYM
admet-2455	232	19	ml	ml	NOUN
admet-2455	232	20	,	,	PUNCT
admet-2455	232	21	respectively	respectively	ADV
admet-2455	232	22	,	,	PUNCT
admet-2455	232	23	for	for	ADP
admet-2455	232	24	24	24	NUM
admet-2455	232	25	h.	h.	PROPN
admet-2455	232	26	(	(	PUNCT
admet-2455	232	27	e	e	NOUN
admet-2455	232	28	)	)	PUNCT
admet-2455	232	29	quantified	quantify	VERB
admet-2455	232	30	results	result	NOUN
admet-2455	232	31	of	of	ADP
admet-2455	232	32	relative	relative	ADJ
admet-2455	232	33	protein	protein	NOUN
admet-2455	232	34	expressions	expression	NOUN
admet-2455	232	35	in	in	ADP
admet-2455	232	36	scc25	scc25	ADJ
admet-2455	232	37	cells	cell	NOUN
admet-2455	232	38	.	.	PUNCT
admet-2455	233	1	data	datum	NOUN
admet-2455	233	2	were	be	AUX
admet-2455	233	3	presented	present	VERB
admet-2455	233	4	as	as	ADP
admet-2455	233	5	mean	mean	NOUN
admet-2455	233	6	±	±	NUM
admet-2455	233	7	se	se	X
admet-2455	233	8	(	(	PUNCT
admet-2455	233	9	n	n	NOUN
admet-2455	233	10	=	=	SYM
admet-2455	233	11	3	3	NUM
admet-2455	233	12	)	)	PUNCT
admet-2455	233	13	;	;	PUNCT
admet-2455	233	14	ns	ns	NUM
admet-2455	233	15	indicates	indicate	VERB
admet-2455	233	16	non	non	ADJ
admet-2455	233	17	-	-	ADJ
admet-2455	233	18	significant	significant	ADJ
admet-2455	233	19	,	,	PUNCT
admet-2455	233	20	*	*	PUNCT
admet-2455	233	21	*	*	PUNCT
admet-2455	233	22	represents	represent	VERB
admet-2455	233	23	p<0.01	p<0.01	PROPN
admet-2455	233	24	,	,	PUNCT
admet-2455	233	25	*	*	PUNCT
admet-2455	233	26	*	*	PUNCT
admet-2455	233	27	*	*	PUNCT
admet-2455	233	28	represents	represent	VERB
admet-2455	233	29	p<0.001	p<0.001	VERB
admet-2455	233	30	,	,	PUNCT
admet-2455	233	31	*	*	PUNCT
admet-2455	233	32	*	*	PUNCT
admet-2455	233	33	*	*	PUNCT
admet-2455	233	34	*	*	PUNCT
admet-2455	233	35	represents	represent	VERB
admet-2455	233	36	p	p	PRON
admet-2455	233	37	<	<	X
admet-2455	233	38	0.0001	0.0001	NUM
admet-2455	233	39	.	.	PUNCT
admet-2455	234	1	subsequent	subsequent	ADJ
admet-2455	234	2	western	western	ADJ
admet-2455	234	3	blotting	blotting	ADJ
admet-2455	234	4	results	result	NOUN
admet-2455	234	5	,	,	PUNCT
admet-2455	234	6	which	which	PRON
admet-2455	234	7	showed	show	VERB
admet-2455	234	8	significantly	significantly	ADV
admet-2455	234	9	promoted	promote	VERB
admet-2455	234	10	phosphorylation	phosphorylation	NOUN
admet-2455	234	11	of	of	ADP
admet-2455	234	12	nf	nf	ADJ
admet-2455	234	13	-	-	PUNCT
admet-2455	234	14	κb	κb	ADJ
admet-2455	234	15	p65	p65	NOUN
admet-2455	234	16	and	and	CCONJ
admet-2455	234	17	p44/42	p44/42	NUM
admet-2455	234	18	mapk	mapk	NOUN
admet-2455	234	19	(	(	PUNCT
admet-2455	234	20	erk1/2	erk1/2	PROPN
admet-2455	234	21	)	)	PUNCT
admet-2455	234	22	,	,	PUNCT
admet-2455	234	23	indicating	indicate	VERB
admet-2455	234	24	the	the	DET
admet-2455	234	25	activations	activation	NOUN
admet-2455	234	26	of	of	ADP
admet-2455	234	27	mapk	mapk	NOUN
admet-2455	234	28	/	/	SYM
admet-2455	234	29	erk	erk	PROPN
admet-2455	234	30	and	and	CCONJ
admet-2455	234	31	nf	nf	ADJ
admet-2455	234	32	-	-	PUNCT
admet-2455	234	33	κb	κb	NOUN
admet-2455	234	34	signalling	signal	VERB
admet-2455	234	35	pathways	pathway	NOUN
admet-2455	234	36	were	be	AUX
admet-2455	234	37	admet	admet	PROPN
admet-2455	234	38	&	&	CCONJ
admet-2455	234	39	dmpk	dmpk	PROPN
admet-2455	234	40	12(6	12(6	NUM
admet-2455	234	41	)	)	PUNCT
admet-2455	234	42	(	(	PUNCT
admet-2455	234	43	2024	2024	NUM
admet-2455	234	44	)	)	PUNCT
admet-2455	234	45	821	821	NUM
admet-2455	234	46	-	-	SYM
admet-2455	234	47	841	841	NUM
admet-2455	234	48	targeting	targeting	NOUN
admet-2455	234	49	hexokinase	hexokinase	NOUN
admet-2455	234	50	2	2	NUM
admet-2455	234	51	to	to	PART
admet-2455	234	52	enhance	enhance	VERB
admet-2455	234	53	anticancer	anticancer	NOUN
admet-2455	234	54	efficacy	efficacy	NOUN
admet-2455	234	55	of	of	ADP
admet-2455	234	56	trichosanthin	trichosanthin	PROPN
admet-2455	234	57	doi	doi	PROPN
admet-2455	234	58	:	:	PUNCT
admet-2455	234	59	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PRON
admet-2455	234	60	835	835	NUM
admet-2455	234	61	induced	induce	VERB
admet-2455	234	62	by	by	ADP
admet-2455	234	63	tcs	tcs	NOUN
admet-2455	234	64	treatment	treatment	NOUN
admet-2455	234	65	alone	alone	ADV
admet-2455	234	66	in	in	ADP
admet-2455	234	67	hela	hela	ADJ
admet-2455	234	68	cells	cell	NOUN
admet-2455	234	69	(	(	PUNCT
admet-2455	234	70	figures	figure	NOUN
admet-2455	234	71	7b	7b	NOUN
admet-2455	234	72	and	and	CCONJ
admet-2455	234	73	7c	7c	NUM
admet-2455	234	74	)	)	PUNCT
admet-2455	234	75	.	.	PUNCT
admet-2455	235	1	intriguingly	intriguingly	ADV
admet-2455	235	2	,	,	PUNCT
admet-2455	235	3	similar	similar	ADJ
admet-2455	235	4	phenomena	phenomenon	NOUN
admet-2455	235	5	were	be	AUX
admet-2455	235	6	also	also	ADV
admet-2455	235	7	observed	observe	VERB
admet-2455	235	8	in	in	ADP
admet-2455	235	9	scc25	scc25	ADJ
admet-2455	235	10	cells	cell	NOUN
admet-2455	235	11	(	(	PUNCT
admet-2455	235	12	figures	figure	NOUN
admet-2455	235	13	7d	7d	NOUN
admet-2455	235	14	and	and	CCONJ
admet-2455	235	15	7e	7e	NUM
admet-2455	235	16	)	)	PUNCT
admet-2455	235	17	.	.	PUNCT
admet-2455	236	1	tcs	tcs	PROPN
admet-2455	236	2	combined	combine	VERB
admet-2455	236	3	with	with	ADP
admet-2455	236	4	benz	benz	PROPN
admet-2455	236	5	inhibited	inhibited	PROPN
admet-2455	236	6	nfκb	nfκb	PROPN
admet-2455	236	7	/	/	SYM
admet-2455	236	8	erk	erk	PROPN
admet-2455	236	9	axis	axis	NOUN
admet-2455	236	10	in	in	ADP
admet-2455	236	11	hela	hela	PROPN
admet-2455	236	12	and	and	CCONJ
admet-2455	236	13	scc25	scc25	PROPN
admet-2455	236	14	cells	cell	NOUN
admet-2455	236	15	next	next	ADV
admet-2455	236	16	,	,	PUNCT
admet-2455	236	17	the	the	DET
admet-2455	236	18	protein	protein	NOUN
admet-2455	236	19	expressions	expression	NOUN
admet-2455	236	20	of	of	ADP
admet-2455	236	21	phospho	phospho	ADJ
admet-2455	236	22	-	-	PUNCT
admet-2455	236	23	nf	nf	NOUN
admet-2455	236	24	-	-	PUNCT
admet-2455	236	25	κb	κb	NOUN
admet-2455	236	26	,	,	PUNCT
admet-2455	236	27	phospho	phospho	NOUN
admet-2455	236	28	-	-	PUNCT
admet-2455	236	29	erk	erk	NOUN
admet-2455	236	30	,	,	PUNCT
admet-2455	236	31	as	as	ADV
admet-2455	236	32	well	well	ADV
admet-2455	236	33	as	as	ADP
admet-2455	236	34	the	the	DET
admet-2455	236	35	ratio	ratio	NOUN
admet-2455	236	36	of	of	ADP
admet-2455	236	37	p	p	NOUN
admet-2455	236	38	-	-	PUNCT
admet-2455	236	39	nf	nf	NOUN
admet-2455	236	40	-	-	PUNCT
admet-2455	236	41	κb	κb	NOUN
admet-2455	236	42	/	/	SYM
admet-2455	236	43	nf	nf	NOUN
admet-2455	236	44	-	-	PUNCT
admet-2455	236	45	κb	κb	NOUN
admet-2455	236	46	and	and	CCONJ
admet-2455	236	47	p	p	PROPN
admet-2455	236	48	-	-	PUNCT
admet-2455	236	49	erk	erk	NOUN
admet-2455	236	50	/	/	SYM
admet-2455	236	51	erk	erk	PROPN
admet-2455	236	52	were	be	AUX
admet-2455	236	53	found	find	VERB
admet-2455	236	54	to	to	PART
admet-2455	236	55	be	be	AUX
admet-2455	236	56	significantly	significantly	ADV
admet-2455	236	57	down	down	ADV
admet-2455	236	58	-	-	PUNCT
admet-2455	236	59	regulated	regulate	VERB
admet-2455	236	60	under	under	ADP
admet-2455	236	61	combined	combined	ADJ
admet-2455	236	62	use	use	NOUN
admet-2455	236	63	of	of	ADP
admet-2455	236	64	tcs	tcs	NOUN
admet-2455	236	65	and	and	CCONJ
admet-2455	236	66	benz	benz	PROPN
admet-2455	236	67	in	in	ADP
admet-2455	236	68	hela	hela	PROPN
admet-2455	236	69	cells	cell	NOUN
admet-2455	236	70	(	(	PUNCT
admet-2455	236	71	figures	figure	NOUN
admet-2455	236	72	8a	8a	NUM
admet-2455	236	73	and	and	CCONJ
admet-2455	236	74	8b	8b	NUM
admet-2455	236	75	)	)	PUNCT
admet-2455	236	76	.	.	PUNCT
admet-2455	237	1	figure	figure	VERB
admet-2455	237	2	8	8	NUM
admet-2455	237	3	.	.	PUNCT
admet-2455	238	1	effect	effect	NOUN
admet-2455	238	2	of	of	ADP
admet-2455	238	3	tcs	tcs	NOUN
admet-2455	238	4	combined	combine	VERB
admet-2455	238	5	with	with	ADP
admet-2455	238	6	benz	benz	PROPN
admet-2455	238	7	treatment	treatment	NOUN
admet-2455	238	8	on	on	ADP
admet-2455	238	9	nf	nf	ADJ
admet-2455	238	10	-	-	PUNCT
admet-2455	238	11	κb	κb	NOUN
admet-2455	238	12	/	/	SYM
admet-2455	238	13	erk	erk	PROPN
admet-2455	238	14	related	relate	VERB
admet-2455	238	15	protein	protein	NOUN
admet-2455	238	16	expression	expression	NOUN
admet-2455	238	17	.	.	PUNCT
admet-2455	239	1	hela	hela	PROPN
admet-2455	239	2	cells	cell	NOUN
admet-2455	239	3	were	be	AUX
admet-2455	239	4	treated	treat	VERB
admet-2455	239	5	with	with	ADP
admet-2455	239	6	6.25	6.25	NUM
admet-2455	239	7	μg	μg	NOUN
admet-2455	239	8	/	/	SYM
admet-2455	239	9	ml	ml	NOUN
admet-2455	239	10	tcs	tcs	NOUN
admet-2455	239	11	and	and	CCONJ
admet-2455	239	12	50	50	NUM
admet-2455	239	13	μm	μm	NOUN
admet-2455	239	14	benz	benz	PROPN
admet-2455	239	15	,	,	PUNCT
admet-2455	239	16	alone	alone	ADJ
admet-2455	239	17	or	or	CCONJ
admet-2455	239	18	in	in	ADP
admet-2455	239	19	combined	combine	VERB
admet-2455	239	20	,	,	PUNCT
admet-2455	239	21	for	for	SCONJ
admet-2455	239	22	24	24	NUM
admet-2455	239	23	h.	h.	PROPN
admet-2455	239	24	scc25	scc25	PROPN
admet-2455	239	25	cells	cell	NOUN
admet-2455	239	26	were	be	AUX
admet-2455	239	27	treated	treat	VERB
admet-2455	239	28	with	with	ADP
admet-2455	239	29	3.13	3.13	NUM
admet-2455	239	30	μg	μg	NOUN
admet-2455	239	31	/	/	SYM
admet-2455	239	32	ml	ml	NOUN
admet-2455	239	33	tcs	tcs	NOUN
admet-2455	239	34	and	and	CCONJ
admet-2455	239	35	25	25	NUM
admet-2455	239	36	μm	μm	NUM
admet-2455	239	37	benz	benz	PROPN
admet-2455	239	38	,	,	PUNCT
admet-2455	239	39	alone	alone	ADJ
admet-2455	239	40	or	or	CCONJ
admet-2455	239	41	in	in	ADP
admet-2455	239	42	combined	combine	VERB
admet-2455	239	43	,	,	PUNCT
admet-2455	239	44	for	for	ADP
admet-2455	239	45	24	24	NUM
admet-2455	239	46	h.	h.	NOUN
admet-2455	239	47	(	(	PUNCT
admet-2455	239	48	a	a	X
admet-2455	239	49	)	)	PUNCT
admet-2455	239	50	western	western	ADJ
admet-2455	239	51	blot	blot	NOUN
admet-2455	239	52	results	result	NOUN
admet-2455	239	53	of	of	ADP
admet-2455	239	54	nf	nf	NOUN
admet-2455	239	55	-	-	PUNCT
admet-2455	239	56	κb	κb	NOUN
admet-2455	239	57	,	,	PUNCT
admet-2455	239	58	p	p	NOUN
admet-2455	239	59	-	-	PUNCT
admet-2455	239	60	nfκb	nfκb	NOUN
admet-2455	239	61	,	,	PUNCT
admet-2455	239	62	erk	erk	PROPN
admet-2455	239	63	,	,	PUNCT
admet-2455	239	64	p	p	PROPN
admet-2455	239	65	-	-	PUNCT
admet-2455	239	66	erk	erk	NOUN
admet-2455	239	67	protein	protein	NOUN
admet-2455	239	68	expressions	expression	NOUN
admet-2455	239	69	in	in	ADP
admet-2455	239	70	hela	hela	ADJ
admet-2455	239	71	cells	cell	NOUN
admet-2455	239	72	.	.	PUNCT
admet-2455	240	1	(	(	PUNCT
admet-2455	240	2	b	b	X
admet-2455	240	3	)	)	PUNCT
admet-2455	240	4	quantification	quantification	NOUN
admet-2455	240	5	results	result	NOUN
admet-2455	240	6	of	of	ADP
admet-2455	240	7	relative	relative	ADJ
admet-2455	240	8	protein	protein	NOUN
admet-2455	240	9	expression	expression	NOUN
admet-2455	240	10	in	in	ADP
admet-2455	240	11	hela	hela	ADJ
admet-2455	240	12	cells	cell	NOUN
admet-2455	240	13	.	.	PUNCT
admet-2455	241	1	(	(	PUNCT
admet-2455	241	2	c	c	X
admet-2455	241	3	)	)	PUNCT
admet-2455	241	4	western	western	ADJ
admet-2455	241	5	blot	blot	NOUN
admet-2455	241	6	results	result	NOUN
admet-2455	241	7	of	of	ADP
admet-2455	241	8	nf	nf	NOUN
admet-2455	241	9	-	-	PUNCT
admet-2455	241	10	κb	κb	NOUN
admet-2455	241	11	,	,	PUNCT
admet-2455	241	12	p	p	NOUN
admet-2455	241	13	-	-	PUNCT
admet-2455	241	14	nf	nf	NOUN
admet-2455	241	15	-	-	PUNCT
admet-2455	241	16	κb	κb	NOUN
admet-2455	241	17	,	,	PUNCT
admet-2455	241	18	erk	erk	PROPN
admet-2455	241	19	,	,	PUNCT
admet-2455	241	20	p	p	PROPN
admet-2455	241	21	-	-	PUNCT
admet-2455	241	22	erk	erk	NOUN
admet-2455	241	23	protein	protein	NOUN
admet-2455	241	24	expressions	expression	NOUN
admet-2455	241	25	in	in	ADP
admet-2455	241	26	scc25	scc25	ADJ
admet-2455	241	27	cells	cell	NOUN
admet-2455	241	28	.	.	PUNCT
admet-2455	242	1	(	(	PUNCT
admet-2455	242	2	d	d	X
admet-2455	242	3	)	)	PUNCT
admet-2455	242	4	quantified	quantified	ADJ
admet-2455	242	5	results	result	NOUN
admet-2455	242	6	of	of	ADP
admet-2455	242	7	relative	relative	ADJ
admet-2455	242	8	protein	protein	NOUN
admet-2455	242	9	expression	expression	NOUN
admet-2455	242	10	in	in	ADP
admet-2455	242	11	scc25	scc25	ADJ
admet-2455	242	12	cells	cell	NOUN
admet-2455	242	13	.	.	PUNCT
admet-2455	243	1	(	(	PUNCT
admet-2455	243	2	e	e	NOUN
admet-2455	243	3	)	)	PUNCT
admet-2455	243	4	examination	examination	NOUN
admet-2455	243	5	of	of	ADP
admet-2455	243	6	nuclear	nuclear	ADJ
admet-2455	243	7	nf	nf	ADJ
admet-2455	243	8	-	-	PUNCT
admet-2455	243	9	κb	κb	NOUN
admet-2455	243	10	protein	protein	NOUN
admet-2455	243	11	expression	expression	NOUN
admet-2455	243	12	within	within	ADP
admet-2455	243	13	nuclear	nuclear	ADJ
admet-2455	243	14	extracts	extract	NOUN
admet-2455	243	15	of	of	ADP
admet-2455	243	16	hela	hela	PROPN
admet-2455	243	17	and	and	CCONJ
admet-2455	243	18	scc25	scc25	NOUN
admet-2455	243	19	cells	cell	NOUN
admet-2455	243	20	.	.	PUNCT
admet-2455	244	1	(	(	PUNCT
admet-2455	244	2	f	f	X
admet-2455	244	3	)	)	PUNCT
admet-2455	244	4	quantified	quantified	ADJ
admet-2455	244	5	results	result	NOUN
admet-2455	244	6	of	of	ADP
admet-2455	244	7	nuclear	nuclear	ADJ
admet-2455	244	8	nf	nf	ADJ
admet-2455	244	9	-	-	PUNCT
admet-2455	244	10	κb	κb	NOUN
admet-2455	244	11	protein	protein	NOUN
admet-2455	244	12	level	level	NOUN
admet-2455	244	13	in	in	ADP
admet-2455	244	14	hela	hela	PROPN
admet-2455	244	15	and	and	CCONJ
admet-2455	244	16	scc25	scc25	PROPN
admet-2455	244	17	cells	cell	NOUN
admet-2455	244	18	.	.	PUNCT
admet-2455	245	1	data	datum	NOUN
admet-2455	245	2	were	be	AUX
admet-2455	245	3	presented	present	VERB
admet-2455	245	4	as	as	ADP
admet-2455	245	5	mean	mean	NOUN
admet-2455	245	6	±	±	NUM
admet-2455	245	7	se	se	X
admet-2455	245	8	(	(	PUNCT
admet-2455	245	9	n	n	NOUN
admet-2455	245	10	=	=	SYM
admet-2455	245	11	3	3	NUM
admet-2455	245	12	)	)	PUNCT
admet-2455	245	13	;	;	PUNCT
admet-2455	245	14	ns	ns	NUM
admet-2455	245	15	indicates	indicate	VERB
admet-2455	245	16	non	non	ADJ
admet-2455	245	17	-	-	ADJ
admet-2455	245	18	significant	significant	ADJ
admet-2455	245	19	,	,	PUNCT
admet-2455	245	20	*	*	PUNCT
admet-2455	245	21	represents	represent	VERB
admet-2455	245	22	p	p	PRON
admet-2455	245	23	<	<	X
admet-2455	245	24	0.05	0.05	NUM
admet-2455	245	25	,	,	PUNCT
admet-2455	245	26	*	*	PUNCT
admet-2455	245	27	*	*	PUNCT
admet-2455	245	28	*	*	PUNCT
admet-2455	245	29	represents	represent	VERB
admet-2455	245	30	p<0.001	p<0.001	VERB
admet-2455	245	31	,	,	PUNCT
admet-2455	245	32	*	*	PUNCT
admet-2455	245	33	*	*	PUNCT
admet-2455	245	34	*	*	PUNCT
admet-2455	245	35	*	*	PUNCT
admet-2455	245	36	represents	represent	VERB
admet-2455	245	37	p	p	PRON
admet-2455	245	38	<	<	X
admet-2455	245	39	0.0001	0.0001	NUM
admet-2455	245	40	.	.	PUNCT
admet-2455	246	1	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PROPN
admet-2455	246	2	y.	y.	PROPN
admet-2455	246	3	zhou	zhou	PROPN
admet-2455	246	4	et	et	PROPN
admet-2455	246	5	al	al	PROPN
admet-2455	246	6	.	.	PROPN
admet-2455	246	7	admet	admet	PROPN
admet-2455	246	8	&	&	CCONJ
admet-2455	246	9	dmpk	dmpk	PROPN
admet-2455	246	10	12(6	12(6	NUM
admet-2455	246	11	)	)	PUNCT
admet-2455	246	12	(	(	PUNCT
admet-2455	246	13	2024	2024	NUM
admet-2455	246	14	)	)	PUNCT
admet-2455	246	15	821	821	NUM
admet-2455	246	16	-	-	SYM
admet-2455	246	17	841	841	NUM
admet-2455	246	18	836	836	NUM
admet-2455	246	19	consistently	consistently	ADV
admet-2455	246	20	,	,	PUNCT
admet-2455	246	21	the	the	DET
admet-2455	246	22	suppression	suppression	NOUN
admet-2455	246	23	the	the	DET
admet-2455	246	24	nf	nf	NOUN
admet-2455	246	25	-	-	PUNCT
admet-2455	246	26	κb	κb	NOUN
admet-2455	246	27	/	/	SYM
admet-2455	246	28	erk	erk	PROPN
admet-2455	246	29	axis	axis	NOUN
admet-2455	246	30	were	be	AUX
admet-2455	246	31	also	also	ADV
admet-2455	246	32	shown	show	VERB
admet-2455	246	33	in	in	ADP
admet-2455	246	34	scc25	scc25	ADJ
admet-2455	246	35	cells	cell	NOUN
admet-2455	246	36	under	under	ADP
admet-2455	246	37	combination	combination	NOUN
admet-2455	246	38	strategy	strategy	NOUN
admet-2455	246	39	(	(	PUNCT
admet-2455	246	40	figures	figure	NOUN
admet-2455	246	41	8c	8c	NOUN
admet-2455	246	42	and	and	CCONJ
admet-2455	246	43	8d	8d	NUM
admet-2455	246	44	)	)	PUNCT
admet-2455	246	45	.	.	PUNCT
admet-2455	247	1	additionally	additionally	ADV
admet-2455	247	2	,	,	PUNCT
admet-2455	247	3	nuclear	nuclear	ADJ
admet-2455	247	4	nf	nf	NOUN
admet-2455	247	5	-	-	PUNCT
admet-2455	247	6	κb	κb	NOUN
admet-2455	247	7	protein	protein	NOUN
admet-2455	247	8	levels	level	NOUN
admet-2455	247	9	were	be	AUX
admet-2455	247	10	prominently	prominently	ADV
admet-2455	247	11	decreased	decrease	VERB
admet-2455	247	12	under	under	ADP
admet-2455	247	13	combination	combination	NOUN
admet-2455	247	14	treatment	treatment	NOUN
admet-2455	247	15	in	in	ADP
admet-2455	247	16	both	both	DET
admet-2455	247	17	cell	cell	NOUN
admet-2455	247	18	lines	line	NOUN
admet-2455	247	19	as	as	SCONJ
admet-2455	247	20	revealed	reveal	VERB
admet-2455	247	21	by	by	ADP
admet-2455	247	22	western	western	ADJ
admet-2455	247	23	blotting	blotting	NOUN
admet-2455	247	24	of	of	ADP
admet-2455	247	25	the	the	DET
admet-2455	247	26	isolated	isolated	ADJ
admet-2455	247	27	nuclear	nuclear	ADJ
admet-2455	247	28	fractions	fraction	NOUN
admet-2455	247	29	,	,	PUNCT
admet-2455	247	30	suggesting	suggest	VERB
admet-2455	247	31	inhibition	inhibition	NOUN
admet-2455	247	32	of	of	ADP
admet-2455	247	33	nuclear	nuclear	ADJ
admet-2455	247	34	translocation	translocation	NOUN
admet-2455	247	35	of	of	ADP
admet-2455	247	36	nf	nf	NOUN
admet-2455	247	37	-	-	PUNCT
admet-2455	247	38	κb	κb	NOUN
admet-2455	247	39	(	(	PUNCT
admet-2455	247	40	figures	figure	NOUN
admet-2455	247	41	8e	8e	NUM
admet-2455	247	42	and	and	CCONJ
admet-2455	247	43	8f	8f	NOUN
admet-2455	247	44	)	)	PUNCT
admet-2455	247	45	.	.	PUNCT
admet-2455	248	1	taken	take	VERB
admet-2455	248	2	together	together	ADV
admet-2455	248	3	,	,	PUNCT
admet-2455	248	4	these	these	DET
admet-2455	248	5	results	result	NOUN
admet-2455	248	6	indicated	indicate	VERB
admet-2455	248	7	that	that	SCONJ
admet-2455	248	8	tcs	tcs	NOUN
admet-2455	248	9	combined	combine	VERB
admet-2455	248	10	with	with	ADP
admet-2455	248	11	benz	benz	PROPN
admet-2455	248	12	had	have	VERB
admet-2455	248	13	great	great	ADJ
admet-2455	248	14	potential	potential	NOUN
admet-2455	248	15	to	to	PART
admet-2455	248	16	interfere	interfere	VERB
admet-2455	248	17	two	two	NUM
admet-2455	248	18	pivotal	pivotal	ADJ
admet-2455	248	19	pro	pro	ADJ
admet-2455	248	20	-	-	ADJ
admet-2455	248	21	survival	survival	ADJ
admet-2455	248	22	signalling	signal	VERB
admet-2455	248	23	activations	activation	NOUN
admet-2455	248	24	,	,	PUNCT
admet-2455	248	25	namely	namely	ADV
admet-2455	248	26	nf	nf	NOUN
admet-2455	248	27	-	-	PUNCT
admet-2455	248	28	κb	κb	NOUN
admet-2455	248	29	and	and	CCONJ
admet-2455	248	30	mapk	mapk	NOUN
admet-2455	248	31	/	/	SYM
admet-2455	248	32	erk	erk	PROPN
admet-2455	248	33	in	in	ADP
admet-2455	248	34	both	both	CCONJ
admet-2455	248	35	hela	hela	PROPN
admet-2455	248	36	and	and	CCONJ
admet-2455	248	37	scc25	scc25	NOUN
admet-2455	248	38	cells	cell	NOUN
admet-2455	248	39	,	,	PUNCT
admet-2455	248	40	mainly	mainly	ADV
admet-2455	248	41	by	by	ADP
admet-2455	248	42	inhibiting	inhibit	VERB
admet-2455	248	43	nf	nf	NOUN
admet-2455	248	44	-	-	PUNCT
admet-2455	248	45	κb	κb	NOUN
admet-2455	248	46	and	and	CCONJ
admet-2455	248	47	erk	erk	PROPN
admet-2455	248	48	phosphorylation	phosphorylation	NOUN
admet-2455	248	49	,	,	PUNCT
admet-2455	248	50	as	as	ADV
admet-2455	248	51	well	well	ADV
admet-2455	248	52	as	as	ADP
admet-2455	248	53	restraining	restrain	VERB
admet-2455	248	54	the	the	DET
admet-2455	248	55	nuclear	nuclear	ADJ
admet-2455	248	56	translocation	translocation	NOUN
admet-2455	248	57	of	of	ADP
admet-2455	248	58	nf	nf	NOUN
admet-2455	248	59	-	-	PUNCT
admet-2455	248	60	κb	κb	NOUN
admet-2455	248	61	.	.	PUNCT
admet-2455	249	1	co	co	NOUN
admet-2455	250	1	-	-	NOUN
admet-2455	250	2	administration	administration	NOUN
admet-2455	250	3	of	of	ADP
admet-2455	250	4	tcs	tcs	PROPN
admet-2455	250	5	and	and	CCONJ
admet-2455	250	6	benz	benz	PROPN
admet-2455	250	7	effectively	effectively	ADV
admet-2455	250	8	inhibited	inhibit	VERB
admet-2455	250	9	tumour	tumour	ADJ
admet-2455	250	10	growth	growth	NOUN
admet-2455	250	11	in	in	ADP
admet-2455	250	12	scc25	scc25	PROPN
admet-2455	250	13	cell	cell	PROPN
admet-2455	250	14	xenograft	xenograft	PROPN
admet-2455	250	15	mouse	mouse	PROPN
admet-2455	250	16	model	model	PROPN
admet-2455	250	17	overall	overall	ADV
admet-2455	250	18	,	,	PUNCT
admet-2455	250	19	our	our	PRON
admet-2455	250	20	in	in	X
admet-2455	250	21	vitro	vitro	X
admet-2455	250	22	data	datum	NOUN
admet-2455	250	23	showed	show	VERB
admet-2455	250	24	that	that	SCONJ
admet-2455	250	25	benz	benz	PROPN
admet-2455	250	26	significantly	significantly	ADV
admet-2455	250	27	enhanced	enhance	VERB
admet-2455	250	28	anticancer	anticancer	NOUN
admet-2455	250	29	effects	effect	NOUN
admet-2455	250	30	of	of	ADP
admet-2455	250	31	tcs	tcs	NOUN
admet-2455	250	32	in	in	ADP
admet-2455	250	33	both	both	CCONJ
admet-2455	250	34	hela	hela	PROPN
admet-2455	250	35	and	and	CCONJ
admet-2455	250	36	scc25	scc25	ADJ
admet-2455	250	37	cells	cell	NOUN
admet-2455	250	38	.	.	PUNCT
admet-2455	251	1	yet	yet	ADV
admet-2455	251	2	,	,	PUNCT
admet-2455	251	3	scc25	scc25	PROPN
admet-2455	251	4	cells	cell	NOUN
admet-2455	251	5	were	be	AUX
admet-2455	251	6	more	more	ADV
admet-2455	251	7	sensitive	sensitive	ADJ
admet-2455	251	8	to	to	ADP
admet-2455	251	9	this	this	DET
admet-2455	251	10	combination	combination	NOUN
admet-2455	251	11	.	.	PUNCT
admet-2455	252	1	to	to	ADP
admet-2455	252	2	this	this	DET
admet-2455	252	3	end	end	NOUN
admet-2455	252	4	,	,	PUNCT
admet-2455	252	5	the	the	DET
admet-2455	252	6	combination	combination	NOUN
admet-2455	252	7	of	of	ADP
admet-2455	252	8	tcs	tcs	NOUN
admet-2455	252	9	and	and	CCONJ
admet-2455	252	10	benz	benz	PROPN
admet-2455	252	11	were	be	AUX
admet-2455	252	12	evaluated	evaluate	VERB
admet-2455	252	13	in	in	ADP
admet-2455	252	14	vivo	vivo	NOUN
admet-2455	252	15	using	use	VERB
admet-2455	252	16	a	a	DET
admet-2455	252	17	scc25	scc25	ADJ
admet-2455	252	18	cell	cell	NOUN
admet-2455	252	19	xenograft	xenograft	PROPN
admet-2455	252	20	mouse	mouse	PROPN
admet-2455	252	21	model	model	NOUN
admet-2455	252	22	.	.	PUNCT
admet-2455	253	1	the	the	DET
admet-2455	253	2	administrations	administration	NOUN
admet-2455	253	3	of	of	ADP
admet-2455	253	4	tcs	tcs	PROPN
admet-2455	253	5	and	and	CCONJ
admet-2455	253	6	benz	benz	PROPN
admet-2455	253	7	,	,	PUNCT
admet-2455	253	8	either	either	CCONJ
admet-2455	253	9	alone	alone	ADJ
admet-2455	253	10	or	or	CCONJ
admet-2455	253	11	in	in	ADP
admet-2455	253	12	combination	combination	NOUN
admet-2455	253	13	,	,	PUNCT
admet-2455	253	14	were	be	AUX
admet-2455	253	15	carried	carry	VERB
admet-2455	253	16	out	out	ADP
admet-2455	253	17	every	every	DET
admet-2455	253	18	other	other	ADJ
admet-2455	253	19	day	day	NOUN
admet-2455	253	20	for	for	ADP
admet-2455	253	21	a	a	DET
admet-2455	253	22	period	period	NOUN
admet-2455	253	23	of	of	ADP
admet-2455	253	24	19	19	NUM
admet-2455	253	25	days	day	NOUN
admet-2455	253	26	.	.	PUNCT
admet-2455	254	1	the	the	DET
admet-2455	254	2	dosage	dosage	NOUN
admet-2455	254	3	used	use	VERB
admet-2455	254	4	was	be	AUX
admet-2455	254	5	1	1	NUM
admet-2455	254	6	mg	mg	PROPN
admet-2455	254	7	/	/	SYM
admet-2455	254	8	kg	kg	PROPN
admet-2455	254	9	for	for	ADP
admet-2455	254	10	tcs	tcs	NOUN
admet-2455	254	11	and	and	CCONJ
admet-2455	254	12	500	500	NUM
admet-2455	254	13	mg	mg	NUM
admet-2455	254	14	/	/	SYM
admet-2455	254	15	kg	kg	PROPN
admet-2455	254	16	for	for	ADP
admet-2455	254	17	benz	benz	PROPN
admet-2455	254	18	.	.	PUNCT
admet-2455	255	1	as	as	SCONJ
admet-2455	255	2	shown	show	VERB
admet-2455	255	3	in	in	ADP
admet-2455	255	4	figure	figure	NOUN
admet-2455	255	5	9a	9a	NOUN
admet-2455	255	6	,	,	PUNCT
admet-2455	255	7	the	the	DET
admet-2455	255	8	combined	combined	ADJ
admet-2455	255	9	use	use	NOUN
admet-2455	255	10	of	of	ADP
admet-2455	255	11	tcs	tcs	NOUN
admet-2455	255	12	and	and	CCONJ
admet-2455	255	13	benz	benz	PROPN
admet-2455	255	14	significantly	significantly	ADV
admet-2455	255	15	suppressed	suppress	VERB
admet-2455	255	16	the	the	DET
admet-2455	255	17	tumour	tumour	NOUN
admet-2455	255	18	growth	growth	NOUN
admet-2455	255	19	,	,	PUNCT
admet-2455	255	20	outperforming	outperform	VERB
admet-2455	255	21	the	the	DET
admet-2455	255	22	single	single	ADJ
admet-2455	255	23	use	use	NOUN
admet-2455	255	24	of	of	ADP
admet-2455	255	25	either	either	DET
admet-2455	255	26	tcs	tcs	PROPN
admet-2455	255	27	or	or	CCONJ
admet-2455	255	28	benz	benz	PROPN
admet-2455	255	29	.	.	PUNCT
admet-2455	256	1	figure	figure	NOUN
admet-2455	256	2	9	9	NUM
admet-2455	256	3	.	.	PUNCT
admet-2455	257	1	the	the	DET
admet-2455	257	2	in	in	ADP
admet-2455	257	3	vivo	vivo	ADJ
admet-2455	257	4	evaluation	evaluation	NOUN
admet-2455	257	5	of	of	ADP
admet-2455	257	6	anti	anti	ADJ
admet-2455	257	7	tumour	tumour	NOUN
admet-2455	257	8	efficacy	efficacy	NOUN
admet-2455	257	9	of	of	ADP
admet-2455	257	10	tcs	tcs	PROPN
admet-2455	257	11	and	and	CCONJ
admet-2455	257	12	benz	benz	PROPN
admet-2455	257	13	combination	combination	NOUN
admet-2455	257	14	in	in	ADP
admet-2455	257	15	scc25	scc25	PROPN
admet-2455	257	16	cell	cell	PROPN
admet-2455	257	17	xenograft	xenograft	PROPN
admet-2455	257	18	mouse	mouse	PROPN
admet-2455	257	19	model	model	NOUN
admet-2455	257	20	.	.	PUNCT
admet-2455	258	1	nude	nude	ADJ
admet-2455	258	2	mice	mouse	NOUN
admet-2455	258	3	aged	age	VERB
admet-2455	258	4	between	between	ADP
admet-2455	258	5	6	6	NUM
admet-2455	258	6	and	and	CCONJ
admet-2455	258	7	8	8	NUM
admet-2455	258	8	weeks	week	NOUN
admet-2455	258	9	were	be	AUX
admet-2455	258	10	randomly	randomly	ADV
admet-2455	258	11	divided	divide	VERB
admet-2455	258	12	into	into	ADP
admet-2455	258	13	four	four	NUM
admet-2455	258	14	groups	group	NOUN
admet-2455	258	15	,	,	PUNCT
admet-2455	258	16	with	with	ADP
admet-2455	258	17	each	each	DET
admet-2455	258	18	group	group	NOUN
admet-2455	258	19	consisting	consist	VERB
admet-2455	258	20	of	of	ADP
admet-2455	258	21	six	six	NUM
admet-2455	258	22	mice	mouse	NOUN
admet-2455	258	23	:	:	PUNCT
admet-2455	258	24	the	the	DET
admet-2455	258	25	vehicle	vehicle	NOUN
admet-2455	258	26	group	group	NOUN
admet-2455	258	27	(	(	PUNCT
admet-2455	258	28	administered	administer	VERB
admet-2455	258	29	with	with	ADP
admet-2455	258	30	pbs	pbs	NOUN
admet-2455	258	31	containing	contain	VERB
admet-2455	258	32	10	10	NUM
admet-2455	258	33	%	%	NOUN
admet-2455	258	34	peg	peg	NOUN
admet-2455	258	35	)	)	PUNCT
admet-2455	258	36	,	,	PUNCT
admet-2455	258	37	the	the	DET
admet-2455	258	38	tcs	tcs	PROPN
admet-2455	258	39	group	group	NOUN
admet-2455	258	40	(	(	PUNCT
admet-2455	258	41	1	1	NUM
admet-2455	258	42	mg	mg	PROPN
admet-2455	258	43	/	/	SYM
admet-2455	258	44	kg	kg	PROPN
admet-2455	258	45	)	)	PUNCT
admet-2455	258	46	,	,	PUNCT
admet-2455	258	47	the	the	DET
admet-2455	258	48	benz	benz	PROPN
admet-2455	258	49	group	group	PROPN
admet-2455	258	50	(	(	PUNCT
admet-2455	258	51	500	500	NUM
admet-2455	258	52	mg	mg	NUM
admet-2455	258	53	/	/	SYM
admet-2455	258	54	kg	kg	PROPN
admet-2455	258	55	)	)	PUNCT
admet-2455	258	56	,	,	PUNCT
admet-2455	258	57	and	and	CCONJ
admet-2455	258	58	the	the	DET
admet-2455	258	59	combination	combination	NOUN
admet-2455	258	60	group	group	NOUN
admet-2455	258	61	(	(	PUNCT
admet-2455	258	62	1mg	1mg	PROPN
admet-2455	258	63	/	/	SYM
admet-2455	258	64	kg	kg	PROPN
admet-2455	258	65	tcs	tcs	NOUN
admet-2455	258	66	+	+	CCONJ
admet-2455	258	67	500	500	NUM
admet-2455	258	68	mg	mg	NUM
admet-2455	258	69	/	/	SYM
admet-2455	258	70	kg	kg	PROPN
admet-2455	258	71	benz	benz	PROPN
admet-2455	258	72	)	)	PUNCT
admet-2455	258	73	.	.	PUNCT
admet-2455	259	1	(	(	PUNCT
admet-2455	259	2	a	a	X
admet-2455	259	3	)	)	PUNCT
admet-2455	259	4	the	the	DET
admet-2455	259	5	tumour	tumour	NOUN
admet-2455	259	6	growth	growth	NOUN
admet-2455	259	7	curve	curve	NOUN
admet-2455	259	8	was	be	AUX
admet-2455	259	9	recorded	record	VERB
admet-2455	259	10	for	for	ADP
admet-2455	259	11	each	each	DET
admet-2455	259	12	administration	administration	NOUN
admet-2455	259	13	group	group	NOUN
admet-2455	259	14	over	over	ADP
admet-2455	259	15	a	a	DET
admet-2455	259	16	period	period	NOUN
admet-2455	259	17	of	of	ADP
admet-2455	259	18	19	19	NUM
admet-2455	259	19	days	day	NOUN
admet-2455	259	20	.	.	PUNCT
admet-2455	260	1	(	(	PUNCT
admet-2455	260	2	b	b	X
admet-2455	260	3	)	)	PUNCT
admet-2455	260	4	at	at	ADP
admet-2455	260	5	the	the	DET
admet-2455	260	6	end	end	NOUN
admet-2455	260	7	of	of	ADP
admet-2455	260	8	the	the	DET
admet-2455	260	9	drug	drug	NOUN
admet-2455	260	10	administration	administration	NOUN
admet-2455	260	11	period	period	NOUN
admet-2455	260	12	,	,	PUNCT
admet-2455	260	13	photographs	photograph	NOUN
admet-2455	260	14	of	of	ADP
admet-2455	260	15	the	the	DET
admet-2455	260	16	harvested	harvest	VERB
admet-2455	260	17	tumour	tumour	NOUN
admet-2455	260	18	s	s	VERB
admet-2455	260	19	were	be	AUX
admet-2455	260	20	taken	take	VERB
admet-2455	260	21	.	.	PUNCT
admet-2455	261	1	(	(	PUNCT
admet-2455	261	2	c	c	X
admet-2455	261	3	,	,	PUNCT
admet-2455	261	4	d	d	NOUN
admet-2455	261	5	)	)	PUNCT
admet-2455	261	6	the	the	DET
admet-2455	261	7	volume	volume	NOUN
admet-2455	261	8	and	and	CCONJ
admet-2455	261	9	weight	weight	NOUN
admet-2455	261	10	of	of	ADP
admet-2455	261	11	the	the	DET
admet-2455	261	12	harvested	harvest	VERB
admet-2455	261	13	tumour	tumour	NOUN
admet-2455	261	14	s	s	VERB
admet-2455	261	15	were	be	AUX
admet-2455	261	16	measured	measure	VERB
admet-2455	261	17	.	.	PUNCT
admet-2455	262	1	(	(	PUNCT
admet-2455	262	2	e	e	X
admet-2455	262	3	)	)	PUNCT
admet-2455	262	4	changes	change	NOUN
admet-2455	262	5	in	in	ADP
admet-2455	262	6	the	the	DET
admet-2455	262	7	body	body	NOUN
admet-2455	262	8	weight	weight	NOUN
admet-2455	262	9	of	of	ADP
admet-2455	262	10	the	the	DET
admet-2455	262	11	animals	animal	NOUN
admet-2455	262	12	were	be	AUX
admet-2455	262	13	monitored	monitor	VERB
admet-2455	262	14	throughout	throughout	ADP
admet-2455	262	15	the	the	DET
admet-2455	262	16	19	19	NUM
admet-2455	262	17	-	-	PUNCT
admet-2455	262	18	day	day	NOUN
admet-2455	262	19	drug	drug	NOUN
admet-2455	262	20	administration	administration	NOUN
admet-2455	262	21	period	period	NOUN
admet-2455	262	22	.	.	PUNCT
admet-2455	263	1	data	datum	NOUN
admet-2455	263	2	were	be	AUX
admet-2455	263	3	presented	present	VERB
admet-2455	263	4	as	as	ADP
admet-2455	263	5	mean	mean	NOUN
admet-2455	263	6	±	±	NUM
admet-2455	263	7	sd	sd	NOUN
admet-2455	263	8	(	(	PUNCT
admet-2455	263	9	n	n	NOUN
admet-2455	263	10	=	=	SYM
admet-2455	263	11	6	6	NUM
admet-2455	263	12	)	)	PUNCT
admet-2455	263	13	;	;	PUNCT
admet-2455	264	1	*	*	PUNCT
admet-2455	264	2	*	*	PUNCT
admet-2455	264	3	*	*	PUNCT
admet-2455	264	4	represents	represent	VERB
admet-2455	264	5	p<0.001	p<0.001	VERB
admet-2455	264	6	,	,	PUNCT
admet-2455	264	7	*	*	PUNCT
admet-2455	264	8	*	*	PUNCT
admet-2455	264	9	*	*	PUNCT
admet-2455	264	10	*	*	PUNCT
admet-2455	264	11	represents	represent	VERB
admet-2455	264	12	p	p	PRON
admet-2455	264	13	<	<	X
admet-2455	264	14	0.0001	0.0001	NUM
admet-2455	264	15	.	.	PUNCT
admet-2455	265	1	admet	admet	PROPN
admet-2455	265	2	&	&	CCONJ
admet-2455	265	3	dmpk	dmpk	PROPN
admet-2455	265	4	12(6	12(6	NUM
admet-2455	265	5	)	)	PUNCT
admet-2455	265	6	(	(	PUNCT
admet-2455	265	7	2024	2024	NUM
admet-2455	265	8	)	)	PUNCT
admet-2455	265	9	821	821	NUM
admet-2455	265	10	-	-	SYM
admet-2455	265	11	841	841	NUM
admet-2455	265	12	targeting	targeting	NOUN
admet-2455	265	13	hexokinase	hexokinase	NOUN
admet-2455	265	14	2	2	NUM
admet-2455	265	15	to	to	PART
admet-2455	265	16	enhance	enhance	VERB
admet-2455	265	17	anticancer	anticancer	NOUN
admet-2455	265	18	efficacy	efficacy	NOUN
admet-2455	265	19	of	of	ADP
admet-2455	265	20	trichosanthin	trichosanthin	PROPN
admet-2455	265	21	doi	doi	PROPN
admet-2455	265	22	:	:	PUNCT
admet-2455	265	23	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PRON
admet-2455	265	24	837	837	NUM
admet-2455	265	25	the	the	DET
admet-2455	265	26	analysis	analysis	NOUN
admet-2455	265	27	of	of	ADP
admet-2455	265	28	tumour	tumour	NOUN
admet-2455	265	29	volume	volume	NOUN
admet-2455	265	30	and	and	CCONJ
admet-2455	265	31	weights	weight	NOUN
admet-2455	265	32	on	on	ADP
admet-2455	265	33	the	the	DET
admet-2455	265	34	final	final	ADJ
admet-2455	265	35	day	day	NOUN
admet-2455	265	36	of	of	ADP
admet-2455	265	37	drug	drug	NOUN
admet-2455	265	38	dosing	dose	VERB
admet-2455	265	39	also	also	ADV
admet-2455	265	40	indicated	indicate	VERB
admet-2455	265	41	the	the	DET
admet-2455	265	42	potent	potent	ADJ
admet-2455	265	43	anti	anti	ADJ
admet-2455	265	44	tumour	tumour	NOUN
admet-2455	265	45	efficacy	efficacy	NOUN
admet-2455	265	46	of	of	ADP
admet-2455	265	47	this	this	DET
admet-2455	265	48	drug	drug	NOUN
admet-2455	265	49	combination	combination	NOUN
admet-2455	265	50	(	(	PUNCT
admet-2455	265	51	figures	figure	NOUN
admet-2455	265	52	9b	9b	NUM
admet-2455	265	53	,	,	PUNCT
admet-2455	265	54	9c	9c	NUM
admet-2455	265	55	and	and	CCONJ
admet-2455	265	56	9	9	NUM
admet-2455	265	57	d	d	NOUN
admet-2455	265	58	)	)	PUNCT
admet-2455	265	59	.	.	PUNCT
admet-2455	266	1	moreover	moreover	ADV
admet-2455	266	2	,	,	PUNCT
admet-2455	266	3	the	the	DET
admet-2455	266	4	daily	daily	ADJ
admet-2455	266	5	activities	activity	NOUN
admet-2455	266	6	and	and	CCONJ
admet-2455	266	7	weight	weight	NOUN
admet-2455	266	8	changes	change	NOUN
admet-2455	266	9	of	of	ADP
admet-2455	266	10	the	the	DET
admet-2455	266	11	animals	animal	NOUN
admet-2455	266	12	were	be	AUX
admet-2455	266	13	minimally	minimally	ADV
admet-2455	266	14	affected	affect	VERB
admet-2455	266	15	by	by	ADP
admet-2455	266	16	the	the	DET
admet-2455	266	17	combined	combine	VERB
admet-2455	266	18	application	application	NOUN
admet-2455	266	19	,	,	PUNCT
admet-2455	266	20	suggesting	suggest	VERB
admet-2455	266	21	negligible	negligible	ADJ
admet-2455	266	22	treatment	treatment	NOUN
admet-2455	266	23	related	relate	VERB
admet-2455	266	24	systemic	systemic	ADJ
admet-2455	266	25	toxicity	toxicity	NOUN
admet-2455	266	26	(	(	PUNCT
admet-2455	266	27	figure	figure	NOUN
admet-2455	266	28	9e	9e	NOUN
admet-2455	266	29	)	)	PUNCT
admet-2455	266	30	.	.	PUNCT
admet-2455	267	1	these	these	DET
admet-2455	267	2	results	result	NOUN
admet-2455	267	3	further	far	ADV
admet-2455	267	4	validated	validate	VERB
admet-2455	267	5	the	the	DET
admet-2455	267	6	plausible	plausible	ADJ
admet-2455	267	7	tumour	tumour	NOUN
admet-2455	267	8	suppressing	suppress	VERB
admet-2455	267	9	efficacy	efficacy	NOUN
admet-2455	267	10	of	of	ADP
admet-2455	267	11	tcs	tcs	PROPN
admet-2455	267	12	and	and	CCONJ
admet-2455	267	13	benz	benz	PROPN
admet-2455	267	14	combination	combination	NOUN
admet-2455	267	15	strategy	strategy	NOUN
admet-2455	267	16	.	.	PUNCT
admet-2455	268	1	discussion	discussion	NOUN
admet-2455	268	2	as	as	ADV
admet-2455	268	3	far	far	ADV
admet-2455	268	4	as	as	SCONJ
admet-2455	268	5	we	we	PRON
admet-2455	268	6	are	be	AUX
admet-2455	268	7	aware	aware	ADJ
admet-2455	268	8	,	,	PUNCT
admet-2455	268	9	the	the	DET
admet-2455	268	10	use	use	NOUN
admet-2455	268	11	of	of	ADP
admet-2455	268	12	tcs	tcs	NOUN
admet-2455	268	13	in	in	ADP
admet-2455	268	14	combination	combination	NOUN
admet-2455	268	15	with	with	ADP
admet-2455	268	16	hk2	hk2	NOUN
admet-2455	268	17	inhibition	inhibition	NOUN
admet-2455	268	18	,	,	PUNCT
admet-2455	268	19	or	or	CCONJ
admet-2455	268	20	glycolytic	glycolytic	ADJ
admet-2455	268	21	inhibition	inhibition	NOUN
admet-2455	268	22	in	in	ADP
admet-2455	268	23	general	general	ADJ
admet-2455	268	24	,	,	PUNCT
admet-2455	268	25	had	have	AUX
admet-2455	268	26	not	not	PART
admet-2455	268	27	been	be	AUX
admet-2455	268	28	undertaken	undertake	VERB
admet-2455	268	29	.	.	PUNCT
admet-2455	269	1	our	our	PRON
admet-2455	269	2	findings	finding	NOUN
admet-2455	269	3	suggested	suggest	VERB
admet-2455	269	4	that	that	SCONJ
admet-2455	269	5	this	this	DET
admet-2455	269	6	combination	combination	NOUN
admet-2455	269	7	might	might	AUX
admet-2455	269	8	offer	offer	VERB
admet-2455	269	9	a	a	DET
admet-2455	269	10	unique	unique	ADJ
admet-2455	269	11	and	and	CCONJ
admet-2455	269	12	innovative	innovative	ADJ
admet-2455	269	13	therapeutic	therapeutic	ADJ
admet-2455	269	14	strategy	strategy	NOUN
admet-2455	269	15	for	for	ADP
admet-2455	269	16	enhancing	enhance	VERB
admet-2455	269	17	the	the	DET
admet-2455	269	18	anticancer	anticancer	NOUN
admet-2455	269	19	effects	effect	NOUN
admet-2455	269	20	of	of	ADP
admet-2455	269	21	tcs	tcs	NOUN
admet-2455	269	22	.	.	PUNCT
admet-2455	270	1	by	by	ADP
admet-2455	270	2	selectively	selectively	ADV
admet-2455	270	3	targeting	target	VERB
admet-2455	270	4	the	the	DET
admet-2455	270	5	aberrant	aberrant	ADJ
admet-2455	270	6	glycolysis	glycolysis	NOUN
admet-2455	270	7	in	in	ADP
admet-2455	270	8	cancer	cancer	NOUN
admet-2455	270	9	cells	cell	NOUN
admet-2455	270	10	,	,	PUNCT
admet-2455	270	11	this	this	DET
admet-2455	270	12	approach	approach	NOUN
admet-2455	270	13	offers	offer	VERB
admet-2455	270	14	great	great	ADJ
admet-2455	270	15	promise	promise	NOUN
admet-2455	270	16	for	for	ADP
admet-2455	270	17	improving	improve	VERB
admet-2455	270	18	cancer	cancer	NOUN
admet-2455	270	19	treatment	treatment	NOUN
admet-2455	270	20	outcomes	outcome	NOUN
admet-2455	270	21	.	.	PUNCT
admet-2455	271	1	prior	prior	ADJ
admet-2455	271	2	studies	study	NOUN
admet-2455	271	3	have	have	AUX
admet-2455	271	4	highlighted	highlight	VERB
admet-2455	271	5	the	the	DET
admet-2455	271	6	critical	critical	ADJ
admet-2455	271	7	role	role	NOUN
admet-2455	271	8	of	of	ADP
admet-2455	271	9	hk2	hk2	PROPN
admet-2455	271	10	in	in	ADP
admet-2455	271	11	promoting	promote	VERB
admet-2455	271	12	tumour	tumour	NOUN
admet-2455	271	13	growth	growth	NOUN
admet-2455	271	14	and	and	CCONJ
admet-2455	271	15	progression	progression	NOUN
admet-2455	271	16	by	by	ADP
admet-2455	271	17	facilitating	facilitate	VERB
admet-2455	271	18	increased	increase	VERB
admet-2455	271	19	glycolytic	glycolytic	ADJ
admet-2455	271	20	activity	activity	NOUN
admet-2455	271	21	[	[	X
admet-2455	271	22	10,32,33	10,32,33	NUM
admet-2455	271	23	]	]	PUNCT
admet-2455	271	24	.	.	PUNCT
admet-2455	272	1	consistent	consistent	ADJ
admet-2455	272	2	with	with	ADP
admet-2455	272	3	previous	previous	ADJ
admet-2455	272	4	studies	study	NOUN
admet-2455	272	5	,	,	PUNCT
admet-2455	272	6	our	our	PRON
admet-2455	272	7	results	result	NOUN
admet-2455	272	8	confirmed	confirm	VERB
admet-2455	272	9	the	the	DET
admet-2455	272	10	significant	significant	ADJ
admet-2455	272	11	upregulation	upregulation	NOUN
admet-2455	272	12	of	of	ADP
admet-2455	272	13	hk2	hk2	NOUN
admet-2455	272	14	expression	expression	NOUN
admet-2455	272	15	in	in	ADP
admet-2455	272	16	malignant	malignant	ADJ
admet-2455	272	17	tumours	tumour	NOUN
admet-2455	272	18	,	,	PUNCT
admet-2455	272	19	emphasizing	emphasize	VERB
admet-2455	272	20	its	its	PRON
admet-2455	272	21	potential	potential	NOUN
admet-2455	272	22	as	as	ADP
admet-2455	272	23	a	a	DET
admet-2455	272	24	therapeutic	therapeutic	ADJ
admet-2455	272	25	target	target	NOUN
admet-2455	272	26	.	.	PUNCT
admet-2455	273	1	importantly	importantly	ADV
admet-2455	273	2	,	,	PUNCT
admet-2455	273	3	we	we	PRON
admet-2455	273	4	found	find	VERB
admet-2455	273	5	that	that	SCONJ
admet-2455	273	6	single	single	ADJ
admet-2455	273	7	use	use	NOUN
admet-2455	273	8	of	of	ADP
admet-2455	273	9	tcs	tcs	NOUN
admet-2455	273	10	significantly	significantly	ADV
admet-2455	273	11	enhanced	enhance	VERB
admet-2455	273	12	hk	hk	PROPN
admet-2455	273	13	activities	activity	NOUN
admet-2455	273	14	,	,	PUNCT
admet-2455	273	15	which	which	PRON
admet-2455	273	16	offered	offer	VERB
admet-2455	273	17	an	an	DET
admet-2455	273	18	exciting	exciting	ADJ
admet-2455	273	19	opportunity	opportunity	NOUN
admet-2455	273	20	for	for	ADP
admet-2455	273	21	combined	combined	ADJ
admet-2455	273	22	use	use	NOUN
admet-2455	273	23	of	of	ADP
admet-2455	273	24	tcs	tcs	NOUN
admet-2455	273	25	and	and	CCONJ
admet-2455	273	26	hk2	hk2	VERB
admet-2455	273	27	inhibitor	inhibitor	NOUN
admet-2455	273	28	to	to	PART
admet-2455	273	29	enhance	enhance	VERB
admet-2455	273	30	anticancer	anticancer	NOUN
admet-2455	273	31	effects	effect	NOUN
admet-2455	273	32	.	.	PUNCT
admet-2455	274	1	in	in	ADP
admet-2455	274	2	the	the	DET
admet-2455	274	3	present	present	ADJ
admet-2455	274	4	study	study	NOUN
admet-2455	274	5	,	,	PUNCT
admet-2455	274	6	the	the	DET
admet-2455	274	7	combination	combination	NOUN
admet-2455	274	8	of	of	ADP
admet-2455	274	9	tcs	tcs	NOUN
admet-2455	274	10	with	with	ADP
admet-2455	274	11	benz	benz	PROPN
admet-2455	274	12	exhibited	exhibit	VERB
admet-2455	274	13	strong	strong	ADJ
admet-2455	274	14	anticancer	anticancer	NOUN
admet-2455	274	15	synergism	synergism	NOUN
admet-2455	274	16	in	in	ADP
admet-2455	274	17	both	both	CCONJ
admet-2455	274	18	hela	hela	PROPN
admet-2455	274	19	and	and	CCONJ
admet-2455	274	20	scc25	scc25	PROPN
admet-2455	274	21	cell	cell	NOUN
admet-2455	274	22	models	model	NOUN
admet-2455	274	23	,	,	PUNCT
admet-2455	274	24	suggesting	suggest	VERB
admet-2455	274	25	hk2	hk2	ADJ
admet-2455	274	26	inhibition	inhibition	NOUN
admet-2455	274	27	can	can	AUX
admet-2455	274	28	effectively	effectively	ADV
admet-2455	274	29	potentiate	potentiate	VERB
admet-2455	274	30	the	the	DET
admet-2455	274	31	anticancer	anticancer	NOUN
admet-2455	274	32	effects	effect	NOUN
admet-2455	274	33	of	of	ADP
admet-2455	274	34	tcs	tcs	NOUN
admet-2455	274	35	.	.	PUNCT
admet-2455	275	1	cancer	cancer	NOUN
admet-2455	275	2	cells	cell	NOUN
admet-2455	275	3	benefit	benefit	VERB
admet-2455	275	4	from	from	ADP
admet-2455	275	5	the	the	DET
admet-2455	275	6	warburg	warburg	NOUN
admet-2455	275	7	effect	effect	NOUN
admet-2455	275	8	via	via	ADP
admet-2455	275	9	increasing	increase	VERB
admet-2455	275	10	glucose	glucose	NOUN
admet-2455	275	11	uptake	uptake	ADJ
admet-2455	275	12	and	and	CCONJ
admet-2455	275	13	stimulating	stimulate	VERB
admet-2455	275	14	lactate	lactate	NOUN
admet-2455	275	15	production	production	NOUN
admet-2455	275	16	[	[	X
admet-2455	275	17	7,40,41	7,40,41	NUM
admet-2455	275	18	]	]	PUNCT
admet-2455	275	19	.	.	PUNCT
admet-2455	276	1	the	the	DET
admet-2455	276	2	addition	addition	NOUN
admet-2455	276	3	of	of	ADP
admet-2455	276	4	benz	benz	PROPN
admet-2455	276	5	in	in	ADP
admet-2455	276	6	tcs	tcs	PROPN
admet-2455	276	7	treatment	treatment	NOUN
admet-2455	276	8	significantly	significantly	ADV
admet-2455	276	9	decreased	decrease	VERB
admet-2455	276	10	cellular	cellular	ADJ
admet-2455	276	11	glycolysis	glycolysis	NOUN
admet-2455	276	12	and	and	CCONJ
admet-2455	276	13	atp	atp	NOUN
admet-2455	276	14	levels	level	NOUN
admet-2455	276	15	.	.	PUNCT
admet-2455	277	1	this	this	DET
admet-2455	277	2	reduction	reduction	NOUN
admet-2455	277	3	indicates	indicate	VERB
admet-2455	277	4	the	the	DET
admet-2455	277	5	disruption	disruption	NOUN
admet-2455	277	6	of	of	ADP
admet-2455	277	7	vital	vital	ADJ
admet-2455	277	8	metabolic	metabolic	NOUN
admet-2455	277	9	pathways	pathway	NOUN
admet-2455	277	10	in	in	ADP
admet-2455	277	11	cancer	cancer	NOUN
admet-2455	277	12	cells	cell	NOUN
admet-2455	277	13	,	,	PUNCT
admet-2455	277	14	leading	lead	VERB
admet-2455	277	15	to	to	ADP
admet-2455	277	16	cellular	cellular	ADJ
admet-2455	277	17	stress	stress	NOUN
admet-2455	277	18	and	and	CCONJ
admet-2455	277	19	compromised	compromised	ADJ
admet-2455	277	20	survival	survival	NOUN
admet-2455	277	21	.	.	PUNCT
admet-2455	278	1	moreover	moreover	ADV
admet-2455	278	2	,	,	PUNCT
admet-2455	278	3	the	the	DET
admet-2455	278	4	combination	combination	NOUN
admet-2455	278	5	therapy	therapy	NOUN
admet-2455	278	6	exhibited	exhibit	VERB
admet-2455	278	7	a	a	DET
admet-2455	278	8	dual	dual	ADJ
admet-2455	278	9	impact	impact	NOUN
admet-2455	278	10	on	on	ADP
admet-2455	278	11	cancer	cancer	NOUN
admet-2455	278	12	cell	cell	NOUN
admet-2455	278	13	behaviour	behaviour	NOUN
admet-2455	278	14	by	by	ADP
admet-2455	278	15	lowering	lower	VERB
admet-2455	278	16	lactate	lactate	NOUN
admet-2455	278	17	secretion	secretion	NOUN
admet-2455	278	18	and	and	CCONJ
admet-2455	278	19	suppressing	suppress	VERB
admet-2455	278	20	colony	colony	NOUN
admet-2455	278	21	-	-	PUNCT
admet-2455	278	22	forming	form	VERB
admet-2455	278	23	ability	ability	NOUN
admet-2455	278	24	.	.	PUNCT
admet-2455	279	1	in	in	ADP
admet-2455	279	2	particular	particular	ADJ
admet-2455	279	3	,	,	PUNCT
admet-2455	279	4	we	we	PRON
admet-2455	279	5	found	find	VERB
admet-2455	279	6	that	that	SCONJ
admet-2455	279	7	the	the	DET
admet-2455	279	8	combination	combination	NOUN
admet-2455	279	9	of	of	ADP
admet-2455	279	10	tcs	tcs	PROPN
admet-2455	279	11	and	and	CCONJ
admet-2455	279	12	benz	benz	PROPN
admet-2455	279	13	induced	induce	VERB
admet-2455	279	14	cell	cell	NOUN
admet-2455	279	15	cycle	cycle	NOUN
admet-2455	279	16	arrested	arrest	VERB
admet-2455	279	17	at	at	ADP
admet-2455	279	18	the	the	DET
admet-2455	279	19	g0	g0	PROPN
admet-2455	279	20	/	/	SYM
admet-2455	279	21	g1	g1	PROPN
admet-2455	279	22	phase	phase	NOUN
admet-2455	279	23	and	and	CCONJ
admet-2455	279	24	blocked	block	VERB
admet-2455	279	25	the	the	DET
admet-2455	279	26	transition	transition	NOUN
admet-2455	279	27	into	into	ADP
admet-2455	279	28	the	the	DET
admet-2455	279	29	g2	g2	PROPN
admet-2455	279	30	/	/	SYM
admet-2455	279	31	m	m	PROPN
admet-2455	279	32	phase	phase	NOUN
admet-2455	279	33	in	in	ADP
admet-2455	279	34	both	both	CCONJ
admet-2455	279	35	hela	hela	PROPN
admet-2455	279	36	and	and	CCONJ
admet-2455	279	37	scc25	scc25	PROPN
admet-2455	279	38	cells	cell	NOUN
admet-2455	279	39	,	,	PUNCT
admet-2455	279	40	which	which	PRON
admet-2455	279	41	further	far	ADV
admet-2455	279	42	substantiated	substantiate	VERB
admet-2455	279	43	its	its	PRON
admet-2455	279	44	inhibitory	inhibitory	ADJ
admet-2455	279	45	effects	effect	NOUN
admet-2455	279	46	on	on	ADP
admet-2455	279	47	cancer	cancer	NOUN
admet-2455	279	48	cell	cell	NOUN
admet-2455	279	49	growth	growth	NOUN
admet-2455	279	50	and	and	CCONJ
admet-2455	279	51	proliferation	proliferation	NOUN
admet-2455	279	52	[	[	X
admet-2455	279	53	42	42	NUM
admet-2455	279	54	]	]	PUNCT
admet-2455	279	55	.	.	PUNCT
admet-2455	280	1	in	in	ADP
admet-2455	280	2	addition	addition	NOUN
admet-2455	280	3	to	to	ADP
admet-2455	280	4	its	its	PRON
admet-2455	280	5	effects	effect	NOUN
admet-2455	280	6	on	on	ADP
admet-2455	280	7	cellular	cellular	ADJ
admet-2455	280	8	metabolism	metabolism	NOUN
admet-2455	280	9	and	and	CCONJ
admet-2455	280	10	cell	cell	NOUN
admet-2455	280	11	cycle	cycle	NOUN
admet-2455	280	12	regulation	regulation	NOUN
admet-2455	280	13	,	,	PUNCT
admet-2455	280	14	the	the	DET
admet-2455	280	15	combination	combination	NOUN
admet-2455	280	16	of	of	ADP
admet-2455	280	17	tcs	tcs	NOUN
admet-2455	280	18	and	and	CCONJ
admet-2455	280	19	benz	benz	PROPN
admet-2455	280	20	exhibited	exhibit	VERB
admet-2455	280	21	profound	profound	ADJ
admet-2455	280	22	impacts	impact	NOUN
admet-2455	280	23	on	on	ADP
admet-2455	280	24	cellular	cellular	ADJ
admet-2455	280	25	apoptosis	apoptosis	NOUN
admet-2455	280	26	.	.	PUNCT
admet-2455	281	1	the	the	DET
admet-2455	281	2	treatment	treatment	NOUN
admet-2455	281	3	increased	increase	VERB
admet-2455	281	4	cellular	cellular	ADJ
admet-2455	281	5	ros	ros	PROPN
admet-2455	281	6	accumulation	accumulation	NOUN
admet-2455	281	7	and	and	CCONJ
admet-2455	281	8	triggered	trigger	VERB
admet-2455	281	9	mitochondria	mitochondria	NOUN
admet-2455	281	10	-	-	PUNCT
admet-2455	281	11	associated	associate	VERB
admet-2455	281	12	cell	cell	NOUN
admet-2455	281	13	apoptosis	apoptosis	NOUN
admet-2455	281	14	.	.	PUNCT
admet-2455	282	1	these	these	DET
admet-2455	282	2	observations	observation	NOUN
admet-2455	282	3	suggest	suggest	VERB
admet-2455	282	4	that	that	SCONJ
admet-2455	282	5	the	the	DET
admet-2455	282	6	combination	combination	NOUN
admet-2455	282	7	therapy	therapy	NOUN
admet-2455	282	8	exerts	exert	VERB
admet-2455	282	9	its	its	PRON
admet-2455	282	10	potent	potent	ADJ
admet-2455	282	11	anticancer	anticancer	NOUN
admet-2455	282	12	effects	effect	NOUN
admet-2455	282	13	by	by	ADP
admet-2455	282	14	inducing	induce	VERB
admet-2455	282	15	oxidative	oxidative	ADJ
admet-2455	282	16	stress	stress	NOUN
admet-2455	282	17	and	and	CCONJ
admet-2455	282	18	promoting	promote	VERB
admet-2455	282	19	programmed	program	VERB
admet-2455	282	20	cell	cell	NOUN
admet-2455	282	21	death	death	NOUN
admet-2455	282	22	.	.	PUNCT
admet-2455	283	1	tcs	tcs	NOUN
admet-2455	283	2	treatment	treatment	NOUN
admet-2455	283	3	alone	alone	ADV
admet-2455	283	4	activated	activate	VERB
admet-2455	283	5	the	the	DET
admet-2455	283	6	nf	nf	NOUN
admet-2455	283	7	-	-	PUNCT
admet-2455	283	8	κb	κb	ADJ
admet-2455	283	9	/	/	SYM
admet-2455	283	10	erk	erk	PROPN
admet-2455	283	11	signalling	signal	VERB
admet-2455	283	12	pathway	pathway	NOUN
admet-2455	283	13	,	,	PUNCT
admet-2455	283	14	which	which	PRON
admet-2455	283	15	can	can	AUX
admet-2455	283	16	be	be	AUX
admet-2455	283	17	rationalized	rationalize	VERB
admet-2455	283	18	as	as	ADP
admet-2455	283	19	a	a	DET
admet-2455	283	20	survival	survival	NOUN
admet-2455	283	21	mechanism	mechanism	NOUN
admet-2455	283	22	of	of	ADP
admet-2455	283	23	the	the	DET
admet-2455	283	24	cancer	cancer	NOUN
admet-2455	283	25	cells	cell	NOUN
admet-2455	283	26	in	in	ADP
admet-2455	283	27	order	order	NOUN
admet-2455	283	28	to	to	PART
admet-2455	283	29	overcome	overcome	VERB
admet-2455	283	30	the	the	DET
admet-2455	283	31	external	external	ADJ
admet-2455	283	32	assault	assault	NOUN
admet-2455	283	33	induced	induce	VERB
admet-2455	283	34	by	by	ADP
admet-2455	283	35	tcs	tcs	PROPN
admet-2455	284	1	[	[	X
admet-2455	284	2	43,44	43,44	X
admet-2455	284	3	]	]	X
admet-2455	284	4	.	.	PUNCT
admet-2455	285	1	previous	previous	ADJ
admet-2455	285	2	study	study	NOUN
admet-2455	285	3	suggested	suggest	VERB
admet-2455	285	4	that	that	SCONJ
admet-2455	285	5	tcs	tcs	NOUN
admet-2455	285	6	-	-	PUNCT
admet-2455	285	7	induced	induce	VERB
admet-2455	285	8	autophagic	autophagic	ADJ
admet-2455	285	9	death	death	NOUN
admet-2455	285	10	of	of	ADP
admet-2455	285	11	cancer	cancer	NOUN
admet-2455	285	12	cells	cell	NOUN
admet-2455	285	13	might	might	AUX
admet-2455	285	14	be	be	AUX
admet-2455	285	15	related	relate	VERB
admet-2455	285	16	to	to	ADP
admet-2455	285	17	the	the	DET
admet-2455	285	18	activation	activation	NOUN
admet-2455	285	19	of	of	ADP
admet-2455	285	20	nfκb	nfκb	ADJ
admet-2455	285	21	pathway	pathway	NOUN
admet-2455	286	1	[	[	X
admet-2455	286	2	45	45	NUM
admet-2455	286	3	]	]	PUNCT
admet-2455	286	4	.	.	PUNCT
admet-2455	287	1	despite	despite	SCONJ
admet-2455	287	2	the	the	DET
admet-2455	287	3	interplays	interplay	NOUN
admet-2455	287	4	between	between	ADP
admet-2455	287	5	autophagy	autophagy	NOUN
admet-2455	287	6	,	,	PUNCT
admet-2455	287	7	cell	cell	NOUN
admet-2455	287	8	death	death	NOUN
admet-2455	287	9	and	and	CCONJ
admet-2455	287	10	nf	nf	NOUN
admet-2455	287	11	-	-	PUNCT
admet-2455	287	12	κb	κb	NOUN
admet-2455	287	13	pathway	pathway	NOUN
admet-2455	287	14	are	be	AUX
admet-2455	287	15	not	not	PART
admet-2455	287	16	fully	fully	ADV
admet-2455	287	17	understood	understand	VERB
admet-2455	287	18	,	,	PUNCT
admet-2455	287	19	the	the	DET
admet-2455	287	20	activation	activation	NOUN
admet-2455	287	21	of	of	ADP
admet-2455	287	22	nf	nf	ADJ
admet-2455	287	23	-	-	PUNCT
admet-2455	287	24	κb	κb	NOUN
admet-2455	287	25	pathway	pathway	NOUN
admet-2455	287	26	appears	appear	VERB
admet-2455	287	27	to	to	PART
admet-2455	287	28	play	play	VERB
admet-2455	287	29	an	an	DET
admet-2455	287	30	irreplaceable	irreplaceable	ADJ
admet-2455	287	31	role	role	NOUN
admet-2455	287	32	in	in	ADP
admet-2455	287	33	promoting	promote	VERB
admet-2455	287	34	cancer	cancer	NOUN
admet-2455	287	35	cell	cell	NOUN
admet-2455	287	36	proliferation	proliferation	NOUN
admet-2455	287	37	[	[	X
admet-2455	287	38	46	46	NUM
admet-2455	287	39	]	]	PUNCT
admet-2455	287	40	.	.	PUNCT
admet-2455	288	1	we	we	PRON
admet-2455	288	2	found	find	VERB
admet-2455	288	3	that	that	SCONJ
admet-2455	288	4	combined	combine	VERB
admet-2455	288	5	use	use	NOUN
admet-2455	288	6	of	of	ADP
admet-2455	288	7	tcs	tcs	NOUN
admet-2455	288	8	and	and	CCONJ
admet-2455	288	9	benz	benz	PROPN
admet-2455	288	10	effectively	effectively	ADV
admet-2455	288	11	inhibited	inhibit	VERB
admet-2455	288	12	the	the	DET
admet-2455	288	13	nf	nf	NOUN
admet-2455	288	14	-	-	PUNCT
admet-2455	288	15	κb	κb	ADJ
admet-2455	288	16	/	/	SYM
admet-2455	288	17	erk	erk	PROPN
admet-2455	288	18	axis	axis	NOUN
admet-2455	288	19	,	,	PUNCT
admet-2455	288	20	thereby	thereby	ADV
admet-2455	288	21	counteracting	counteract	VERB
admet-2455	288	22	the	the	DET
admet-2455	288	23	pro	pro	ADJ
admet-2455	288	24	-	-	ADJ
admet-2455	288	25	survival	survival	ADJ
admet-2455	288	26	signalling	signal	VERB
admet-2455	288	27	pathways	pathway	NOUN
admet-2455	288	28	activated	activate	VERB
admet-2455	288	29	by	by	ADP
admet-2455	288	30	tcs	tcs	NOUN
admet-2455	288	31	alone	alone	ADV
admet-2455	288	32	.	.	PUNCT
admet-2455	289	1	the	the	DET
admet-2455	289	2	decrease	decrease	NOUN
admet-2455	289	3	in	in	ADP
admet-2455	289	4	nuclear	nuclear	ADJ
admet-2455	289	5	nf	nf	ADJ
admet-2455	289	6	-	-	PUNCT
admet-2455	289	7	κb	κb	ADJ
admet-2455	289	8	protein	protein	NOUN
admet-2455	289	9	levels	level	NOUN
admet-2455	289	10	,	,	PUNCT
admet-2455	289	11	as	as	SCONJ
admet-2455	289	12	observed	observe	VERB
admet-2455	289	13	through	through	ADP
admet-2455	289	14	western	western	ADJ
admet-2455	289	15	blotting	blotting	ADJ
admet-2455	289	16	analysis	analysis	NOUN
admet-2455	289	17	,	,	PUNCT
admet-2455	289	18	indicated	indicate	VERB
admet-2455	289	19	that	that	SCONJ
admet-2455	289	20	the	the	DET
admet-2455	289	21	combination	combination	NOUN
admet-2455	289	22	treatment	treatment	NOUN
admet-2455	289	23	inhibited	inhibit	VERB
admet-2455	289	24	the	the	DET
admet-2455	289	25	nuclear	nuclear	ADJ
admet-2455	289	26	translocation	translocation	NOUN
admet-2455	289	27	of	of	ADP
admet-2455	289	28	nf	nf	NOUN
admet-2455	289	29	-	-	PUNCT
admet-2455	289	30	κb	κb	NOUN
admet-2455	289	31	,	,	PUNCT
admet-2455	289	32	effectively	effectively	ADV
admet-2455	289	33	contributing	contribute	VERB
admet-2455	289	34	to	to	ADP
admet-2455	289	35	the	the	DET
admet-2455	289	36	anticancer	anticancer	NOUN
admet-2455	289	37	effects	effect	NOUN
admet-2455	289	38	.	.	PUNCT
admet-2455	290	1	based	base	VERB
admet-2455	290	2	on	on	ADP
admet-2455	290	3	prior	prior	ADV
admet-2455	290	4	in	in	ADP
admet-2455	290	5	vivo	vivo	NOUN
admet-2455	290	6	study	study	NOUN
admet-2455	290	7	,	,	PUNCT
admet-2455	290	8	benz	benz	PROPN
admet-2455	290	9	was	be	AUX
admet-2455	290	10	shown	show	VERB
admet-2455	290	11	to	to	PART
admet-2455	290	12	be	be	AUX
admet-2455	290	13	a	a	DET
admet-2455	290	14	safe	safe	ADJ
admet-2455	290	15	agent	agent	NOUN
admet-2455	290	16	as	as	ADP
admet-2455	290	17	no	no	DET
admet-2455	290	18	significant	significant	ADJ
admet-2455	290	19	weight	weight	NOUN
admet-2455	290	20	loss	loss	NOUN
admet-2455	290	21	or	or	CCONJ
admet-2455	290	22	changes	change	NOUN
admet-2455	290	23	in	in	ADP
admet-2455	290	24	tissue	tissue	NOUN
admet-2455	290	25	morphology	morphology	NOUN
admet-2455	290	26	were	be	AUX
admet-2455	290	27	observed	observe	VERB
admet-2455	290	28	in	in	ADP
admet-2455	290	29	mice	mouse	NOUN
admet-2455	290	30	with	with	ADP
admet-2455	290	31	daily	daily	PROPN
admet-2455	290	32	i.p	i.p	PROPN
admet-2455	290	33	.	.	PROPN
admet-2455	290	34	injections	injection	NOUN
admet-2455	290	35	of	of	ADP
admet-2455	290	36	up	up	ADP
admet-2455	290	37	to	to	PART
admet-2455	290	38	600	600	NUM
admet-2455	290	39	mg	mg	NUM
admet-2455	290	40	/	/	SYM
admet-2455	290	41	kg	kg	NOUN
admet-2455	290	42	body	body	NOUN
admet-2455	290	43	weight	weight	NOUN
admet-2455	290	44	of	of	ADP
admet-2455	290	45	benz	benz	PROPN
admet-2455	290	46	for	for	ADP
admet-2455	290	47	16	16	NUM
admet-2455	290	48	days	day	NOUN
admet-2455	291	1	[	[	X
admet-2455	291	2	25	25	NUM
admet-2455	291	3	]	]	PUNCT
admet-2455	291	4	.	.	PUNCT
admet-2455	292	1	recent	recent	ADJ
admet-2455	292	2	studies	study	NOUN
admet-2455	292	3	suggested	suggest	VERB
admet-2455	292	4	that	that	SCONJ
admet-2455	292	5	high	high	ADJ
admet-2455	292	6	doses	dose	NOUN
admet-2455	292	7	of	of	ADP
admet-2455	292	8	tcs	tcs	PROPN
admet-2455	292	9	administration	administration	NOUN
admet-2455	292	10	alone	alone	ADV
admet-2455	292	11	can	can	AUX
admet-2455	292	12	be	be	AUX
admet-2455	292	13	toxic	toxic	ADJ
admet-2455	293	1	[	[	X
admet-2455	293	2	47,48	47,48	NOUN
admet-2455	293	3	]	]	X
admet-2455	293	4	.	.	PUNCT
admet-2455	294	1	minimal	minimal	ADJ
admet-2455	294	2	side	side	NOUN
admet-2455	294	3	effects	effect	NOUN
admet-2455	294	4	were	be	AUX
admet-2455	294	5	shown	show	VERB
admet-2455	294	6	by	by	ADP
admet-2455	294	7	i.p	i.p	PROPN
admet-2455	294	8	.	.	PROPN
admet-2455	294	9	administration	administration	PROPN
admet-2455	294	10	of	of	ADP
admet-2455	294	11	low	low	PROPN
admet-2455	294	12	dose	dose	PROPN
admet-2455	294	13	of	of	ADP
admet-2455	294	14	0.5	0.5	NUM
admet-2455	294	15	-	-	SYM
admet-2455	294	16	1.0	1.0	NUM
admet-2455	294	17	mg	mg	NUM
admet-2455	294	18	/	/	SYM
admet-2455	294	19	kg	kg	PROPN
admet-2455	294	20	tcs	tcs	NOUN
admet-2455	294	21	for	for	ADP
admet-2455	294	22	19	19	NUM
admet-2455	294	23	days	day	NOUN
admet-2455	294	24	,	,	PUNCT
admet-2455	294	25	but	but	CCONJ
admet-2455	294	26	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	ADP
admet-2455	294	27	y.	y.	NOUN
admet-2455	294	28	zhou	zhou	PROPN
admet-2455	294	29	et	et	PROPN
admet-2455	294	30	al	al	PROPN
admet-2455	294	31	.	.	PROPN
admet-2455	294	32	admet	admet	PROPN
admet-2455	294	33	&	&	CCONJ
admet-2455	294	34	dmpk	dmpk	PROPN
admet-2455	294	35	12(6	12(6	NUM
admet-2455	294	36	)	)	PUNCT
admet-2455	294	37	(	(	PUNCT
admet-2455	294	38	2024	2024	NUM
admet-2455	294	39	)	)	PUNCT
admet-2455	294	40	821	821	NUM
admet-2455	294	41	-	-	SYM
admet-2455	294	42	841	841	NUM
admet-2455	294	43	838	838	NUM
admet-2455	294	44	there	there	PRON
admet-2455	294	45	was	be	VERB
admet-2455	294	46	a	a	DET
admet-2455	294	47	tendency	tendency	NOUN
admet-2455	294	48	for	for	SCONJ
admet-2455	294	49	mice	mouse	NOUN
admet-2455	294	50	to	to	PART
admet-2455	294	51	lose	lose	VERB
admet-2455	294	52	weight	weight	NOUN
admet-2455	294	53	at	at	ADP
admet-2455	294	54	tcs	tcs	PROPN
admet-2455	294	55	doses	dose	NOUN
admet-2455	294	56	up	up	ADV
admet-2455	294	57	to	to	ADP
admet-2455	294	58	2.0	2.0	NUM
admet-2455	294	59	mg	mg	NOUN
admet-2455	294	60	/	/	SYM
admet-2455	294	61	kg	kg	PROPN
admet-2455	295	1	[	[	X
admet-2455	295	2	18	18	NUM
admet-2455	295	3	,	,	PUNCT
admet-2455	295	4	23	23	NUM
admet-2455	295	5	]	]	PUNCT
admet-2455	295	6	.	.	PUNCT
admet-2455	296	1	importantly	importantly	ADV
admet-2455	296	2	,	,	PUNCT
admet-2455	296	3	our	our	PRON
admet-2455	296	4	in	in	ADP
admet-2455	296	5	vivo	vivo	ADJ
admet-2455	296	6	experiments	experiment	NOUN
admet-2455	296	7	using	use	VERB
admet-2455	296	8	a	a	DET
admet-2455	296	9	scc25	scc25	ADJ
admet-2455	296	10	cell	cell	NOUN
admet-2455	296	11	xenograft	xenograft	PROPN
admet-2455	296	12	mouse	mouse	PROPN
admet-2455	296	13	model	model	NOUN
admet-2455	296	14	clearly	clearly	ADV
admet-2455	296	15	demonstrated	demonstrate	VERB
admet-2455	296	16	that	that	SCONJ
admet-2455	296	17	the	the	DET
admet-2455	296	18	combined	combined	ADJ
admet-2455	296	19	use	use	NOUN
admet-2455	296	20	of	of	ADP
admet-2455	296	21	tcs	tcs	NOUN
admet-2455	296	22	and	and	CCONJ
admet-2455	296	23	benz	benz	PROPN
admet-2455	296	24	effectively	effectively	ADV
admet-2455	296	25	inhibited	inhibit	VERB
admet-2455	296	26	tumour	tumour	ADJ
admet-2455	296	27	growth	growth	NOUN
admet-2455	296	28	at	at	ADP
admet-2455	296	29	a	a	DET
admet-2455	296	30	low	low	ADJ
admet-2455	296	31	dose	dose	NOUN
admet-2455	296	32	(	(	PUNCT
admet-2455	296	33	1.0	1.0	NUM
admet-2455	296	34	mg	mg	PROPN
admet-2455	296	35	/	/	SYM
admet-2455	296	36	kg	kg	PROPN
admet-2455	296	37	tcs	tcs	NOUN
admet-2455	296	38	500	500	NUM
admet-2455	296	39	mg	mg	PROPN
admet-2455	296	40	/	/	SYM
admet-2455	296	41	kg	kg	PROPN
admet-2455	296	42	benz	benz	PROPN
admet-2455	296	43	)	)	PUNCT
admet-2455	296	44	,	,	PUNCT
admet-2455	296	45	leading	lead	VERB
admet-2455	296	46	to	to	ADP
admet-2455	296	47	tumour	tumour	NOUN
admet-2455	296	48	regression	regression	NOUN
admet-2455	296	49	without	without	ADP
admet-2455	296	50	any	any	DET
admet-2455	296	51	observable	observable	ADJ
admet-2455	296	52	side	side	NOUN
admet-2455	296	53	effects	effect	NOUN
admet-2455	296	54	.	.	PUNCT
admet-2455	297	1	these	these	DET
admet-2455	297	2	results	result	NOUN
admet-2455	297	3	clearly	clearly	ADV
admet-2455	297	4	supported	support	VERB
admet-2455	297	5	the	the	DET
admet-2455	297	6	translational	translational	ADJ
admet-2455	297	7	potential	potential	NOUN
admet-2455	297	8	of	of	ADP
admet-2455	297	9	the	the	DET
admet-2455	297	10	tcs	tcs	PROPN
admet-2455	297	11	-	-	PUNCT
admet-2455	297	12	benz	benz	PROPN
admet-2455	297	13	combo	combo	NOUN
admet-2455	297	14	in	in	ADP
admet-2455	297	15	anticancer	anticancer	NOUN
admet-2455	297	16	treatment	treatment	NOUN
admet-2455	297	17	.	.	PUNCT
admet-2455	298	1	conclusions	conclusion	NOUN
admet-2455	298	2	our	our	PRON
admet-2455	298	3	findings	finding	NOUN
admet-2455	298	4	highlighted	highlight	VERB
admet-2455	298	5	the	the	DET
admet-2455	298	6	strong	strong	ADJ
admet-2455	298	7	synergistic	synergistic	ADJ
admet-2455	298	8	anticancer	anticancer	NOUN
admet-2455	298	9	effects	effect	NOUN
admet-2455	298	10	by	by	ADP
admet-2455	298	11	combining	combine	VERB
admet-2455	298	12	tcs	tcs	NOUN
admet-2455	298	13	with	with	ADP
admet-2455	298	14	benz	benz	PROPN
admet-2455	298	15	in	in	ADP
admet-2455	298	16	hela	hela	PROPN
admet-2455	298	17	and	and	CCONJ
admet-2455	298	18	scc25	scc25	PROPN
admet-2455	298	19	cancer	cancer	NOUN
admet-2455	298	20	cell	cell	NOUN
admet-2455	298	21	models	model	NOUN
admet-2455	298	22	.	.	PUNCT
admet-2455	299	1	the	the	DET
admet-2455	299	2	combination	combination	NOUN
admet-2455	299	3	of	of	ADP
admet-2455	299	4	tcs	tcs	PROPN
admet-2455	299	5	and	and	CCONJ
admet-2455	299	6	benz	benz	PROPN
admet-2455	299	7	demonstrated	demonstrate	VERB
admet-2455	299	8	great	great	ADJ
admet-2455	299	9	potential	potential	NOUN
admet-2455	299	10	for	for	ADP
admet-2455	299	11	interfering	interfere	VERB
admet-2455	299	12	with	with	ADP
admet-2455	299	13	pro	pro	ADJ
admet-2455	299	14	-	-	ADJ
admet-2455	299	15	survival	survival	ADJ
admet-2455	299	16	signalling	signal	VERB
admet-2455	299	17	pathways	pathway	NOUN
admet-2455	299	18	,	,	PUNCT
admet-2455	299	19	namely	namely	ADV
admet-2455	299	20	,	,	PUNCT
admet-2455	299	21	nf	nf	ADJ
admet-2455	299	22	-	-	PUNCT
admet-2455	299	23	κb	κb	NOUN
admet-2455	299	24	and	and	CCONJ
admet-2455	299	25	mapk	mapk	PROPN
admet-2455	299	26	/	/	SYM
admet-2455	299	27	erk	erk	PROPN
admet-2455	299	28	,	,	PUNCT
admet-2455	299	29	to	to	PART
admet-2455	299	30	facilitate	facilitate	VERB
admet-2455	299	31	cancer	cancer	NOUN
admet-2455	299	32	cell	cell	NOUN
admet-2455	299	33	killing	killing	NOUN
admet-2455	299	34	.	.	PUNCT
admet-2455	300	1	moreover	moreover	ADV
admet-2455	300	2	,	,	PUNCT
admet-2455	300	3	the	the	DET
admet-2455	300	4	observed	observe	VERB
admet-2455	300	5	effects	effect	NOUN
admet-2455	300	6	on	on	ADP
admet-2455	300	7	glycolysis	glycolysis	NOUN
admet-2455	300	8	,	,	PUNCT
admet-2455	300	9	ros	ros	PROPN
admet-2455	300	10	accumulation	accumulation	NOUN
admet-2455	300	11	,	,	PUNCT
admet-2455	300	12	cell	cell	NOUN
admet-2455	300	13	cycle	cycle	NOUN
admet-2455	300	14	regulation	regulation	NOUN
admet-2455	300	15	,	,	PUNCT
admet-2455	300	16	and	and	CCONJ
admet-2455	300	17	apoptosis	apoptosis	NOUN
admet-2455	300	18	induction	induction	NOUN
admet-2455	300	19	collectively	collectively	ADV
admet-2455	300	20	contributed	contribute	VERB
admet-2455	300	21	to	to	ADP
admet-2455	300	22	the	the	DET
admet-2455	300	23	multifaceted	multifaceted	ADJ
admet-2455	300	24	mechanisms	mechanism	NOUN
admet-2455	300	25	through	through	ADP
admet-2455	300	26	which	which	PRON
admet-2455	300	27	the	the	DET
admet-2455	300	28	tcs	tcs	PROPN
admet-2455	300	29	-	-	PUNCT
admet-2455	300	30	benz	benz	PROPN
admet-2455	300	31	combo	combo	PROPN
admet-2455	300	32	exerted	exert	VERB
admet-2455	300	33	its	its	PRON
admet-2455	300	34	potent	potent	ADJ
admet-2455	300	35	anticancer	anticancer	NOUN
admet-2455	300	36	effects	effect	NOUN
admet-2455	300	37	.	.	PUNCT
admet-2455	301	1	this	this	DET
admet-2455	301	2	study	study	NOUN
admet-2455	301	3	provides	provide	VERB
admet-2455	301	4	valuable	valuable	ADJ
admet-2455	301	5	insights	insight	NOUN
admet-2455	301	6	for	for	ADP
admet-2455	301	7	potential	potential	ADJ
admet-2455	301	8	therapeutic	therapeutic	ADJ
admet-2455	301	9	strategies	strategy	NOUN
admet-2455	301	10	that	that	PRON
admet-2455	301	11	can	can	AUX
admet-2455	301	12	enhance	enhance	VERB
admet-2455	301	13	the	the	DET
admet-2455	301	14	anticancer	anticancer	NOUN
admet-2455	301	15	efficacy	efficacy	NOUN
admet-2455	301	16	of	of	ADP
admet-2455	301	17	tcs	tcs	NOUN
admet-2455	301	18	by	by	ADP
admet-2455	301	19	targeting	target	VERB
admet-2455	301	20	hk2	hk2	PROPN
admet-2455	301	21	,	,	PUNCT
admet-2455	301	22	suggesting	suggest	VERB
admet-2455	301	23	that	that	SCONJ
admet-2455	301	24	modulating	modulate	VERB
admet-2455	301	25	aberrant	aberrant	ADJ
admet-2455	301	26	glycolysis	glycolysis	NOUN
admet-2455	301	27	holds	hold	VERB
admet-2455	301	28	a	a	DET
admet-2455	301	29	promise	promise	NOUN
admet-2455	301	30	to	to	PART
admet-2455	301	31	enhance	enhance	VERB
admet-2455	301	32	the	the	DET
admet-2455	301	33	sensitivity	sensitivity	NOUN
admet-2455	301	34	of	of	ADP
admet-2455	301	35	cancer	cancer	NOUN
admet-2455	301	36	cell	cell	NOUN
admet-2455	301	37	to	to	ADP
admet-2455	301	38	tcs	tcs	NOUN
admet-2455	301	39	-	-	PUNCT
admet-2455	301	40	based	base	VERB
admet-2455	301	41	therapeutic	therapeutic	ADJ
admet-2455	301	42	strategy	strategy	NOUN
admet-2455	301	43	.	.	PUNCT
admet-2455	302	1	acknowledgements	acknowledgement	NOUN
admet-2455	302	2	:	:	PUNCT
admet-2455	303	1	we	we	PRON
admet-2455	303	2	thank	thank	VERB
admet-2455	303	3	prof	prof	PROPN
admet-2455	303	4	.	.	PUNCT
admet-2455	304	1	guokai	guokai	PROPN
admet-2455	304	2	chen	chen	PROPN
admet-2455	304	3	(	(	PUNCT
admet-2455	304	4	fhs	fhs	PROPN
admet-2455	304	5	,	,	PUNCT
admet-2455	304	6	university	university	PROPN
admet-2455	304	7	of	of	ADP
admet-2455	304	8	macau	macau	PROPN
admet-2455	304	9	)	)	PUNCT
admet-2455	304	10	for	for	ADP
admet-2455	304	11	sample	sample	NOUN
admet-2455	304	12	of	of	ADP
admet-2455	304	13	human	human	ADJ
admet-2455	304	14	fibroblast	fibroblast	ADJ
admet-2455	304	15	cell	cell	NOUN
admet-2455	304	16	line	line	NOUN
admet-2455	304	17	,	,	PUNCT
admet-2455	304	18	and	and	CCONJ
admet-2455	304	19	the	the	DET
admet-2455	304	20	technical	technical	ADJ
admet-2455	304	21	support	support	NOUN
admet-2455	304	22	from	from	ADP
admet-2455	304	23	animal	animal	NOUN
admet-2455	304	24	research	research	NOUN
admet-2455	304	25	core	core	NOUN
admet-2455	304	26	and	and	CCONJ
admet-2455	304	27	biological	biological	ADJ
admet-2455	304	28	imaging	imaging	NOUN
admet-2455	304	29	&	&	CCONJ
admet-2455	304	30	stem	stem	NOUN
admet-2455	304	31	cell	cell	NOUN
admet-2455	304	32	core	core	NOUN
admet-2455	304	33	at	at	ADP
admet-2455	304	34	faculty	faculty	NOUN
admet-2455	304	35	of	of	ADP
admet-2455	304	36	heath	heath	PROPN
admet-2455	304	37	sciences	sciences	PROPN
admet-2455	304	38	,	,	PUNCT
admet-2455	304	39	university	university	NOUN
admet-2455	304	40	of	of	ADP
admet-2455	304	41	macau	macau	PROPN
admet-2455	304	42	.	.	PUNCT
admet-2455	305	1	this	this	DET
admet-2455	305	2	work	work	NOUN
admet-2455	305	3	was	be	AUX
admet-2455	305	4	financially	financially	ADV
admet-2455	305	5	supported	support	VERB
admet-2455	305	6	by	by	ADP
admet-2455	305	7	the	the	DET
admet-2455	305	8	science	science	NOUN
admet-2455	305	9	and	and	CCONJ
admet-2455	305	10	technology	technology	NOUN
admet-2455	305	11	development	development	NOUN
admet-2455	305	12	fund	fund	PROPN
admet-2455	305	13	,	,	PUNCT
admet-2455	305	14	macau	macau	PROPN
admet-2455	305	15	sar	sar	PROPN
admet-2455	305	16	(	(	PUNCT
admet-2455	305	17	file	file	VERB
admet-2455	305	18	no	no	INTJ
admet-2455	305	19	.	.	PUNCT
admet-2455	305	20	0138/2022	0138/2022	NUM
admet-2455	305	21	/	/	SYM
admet-2455	305	22	a	a	NOUN
admet-2455	305	23	)	)	PUNCT
admet-2455	305	24	to	to	ADP
admet-2455	305	25	k.y	k.y	PROPN
admet-2455	305	26	.	.	PROPN
admet-2455	305	27	tam	tam	PROPN
admet-2455	305	28	,	,	PUNCT
admet-2455	305	29	the	the	DET
admet-2455	305	30	national	national	PROPN
admet-2455	305	31	science	science	PROPN
admet-2455	305	32	foundation	foundation	PROPN
admet-2455	305	33	of	of	ADP
admet-2455	305	34	china	china	PROPN
admet-2455	305	35	(	(	PUNCT
admet-2455	305	36	81773939	81773939	NUM
admet-2455	305	37	)	)	PUNCT
admet-2455	305	38	and	and	CCONJ
admet-2455	305	39	technology	technology	NOUN
admet-2455	305	40	foundation	foundation	PROPN
admet-2455	305	41	of	of	ADP
admet-2455	305	42	shenzhen	shenzhen	PROPN
admet-2455	305	43	city	city	PROPN
admet-2455	305	44	(	(	PUNCT
admet-2455	305	45	jcyj20210324094005015	jcyj20210324094005015	PROPN
admet-2455	305	46	)	)	PUNCT
admet-2455	305	47	to	to	ADP
admet-2455	305	48	o.	o.	PROPN
admet-2455	305	49	sha	sha	PROPN
admet-2455	305	50	.	.	PUNCT
admet-2455	306	1	conflict	conflict	NOUN
admet-2455	306	2	of	of	ADP
admet-2455	306	3	interest	interest	NOUN
admet-2455	306	4	:	:	PUNCT
admet-2455	306	5	the	the	DET
admet-2455	306	6	authors	author	NOUN
admet-2455	306	7	declare	declare	VERB
admet-2455	306	8	no	no	DET
admet-2455	306	9	conflict	conflict	NOUN
admet-2455	306	10	of	of	ADP
admet-2455	306	11	interest	interest	NOUN
admet-2455	306	12	for	for	ADP
admet-2455	306	13	this	this	DET
admet-2455	306	14	article	article	NOUN
admet-2455	306	15	.	.	PUNCT
admet-2455	307	1	references	reference	NOUN
admet-2455	307	2	[	[	X
admet-2455	307	3	1	1	X
admet-2455	307	4	]	]	PUNCT
admet-2455	307	5	j.	j.	PROPN
admet-2455	307	6	luo	luo	PROPN
admet-2455	307	7	,	,	PUNCT
admet-2455	307	8	n.l	n.l	PROPN
admet-2455	307	9	.	.	PROPN
admet-2455	307	10	solimini	solimini	PROPN
admet-2455	307	11	,	,	PUNCT
admet-2455	307	12	s.j	s.j	PROPN
admet-2455	307	13	.	.	PROPN
admet-2455	307	14	elledge	elledge	PROPN
admet-2455	307	15	.	.	PUNCT
admet-2455	308	1	principles	principle	NOUN
admet-2455	308	2	of	of	ADP
admet-2455	308	3	cancer	cancer	NOUN
admet-2455	308	4	therapy	therapy	NOUN
admet-2455	308	5	:	:	PUNCT
admet-2455	308	6	oncogene	oncogene	NOUN
admet-2455	308	7	and	and	CCONJ
admet-2455	308	8	non	non	ADJ
admet-2455	308	9	-	-	ADJ
admet-2455	308	10	oncogene	oncogene	ADJ
admet-2455	308	11	addiction	addiction	NOUN
admet-2455	308	12	.	.	PUNCT
admet-2455	309	1	cell	cell	NOUN
admet-2455	309	2	136	136	NUM
admet-2455	309	3	(	(	PUNCT
admet-2455	309	4	2009	2009	NUM
admet-2455	309	5	)	)	PUNCT
admet-2455	309	6	823	823	NUM
admet-2455	309	7	-	-	SYM
admet-2455	309	8	837	837	NUM
admet-2455	309	9	.	.	PUNCT
admet-2455	310	1	https://doi.org/10.1016/j.cell.2009.02.024	https://doi.org/10.1016/j.cell.2009.02.024	VERB
admet-2455	310	2	.	.	PUNCT
admet-2455	311	1	[	[	X
admet-2455	311	2	2	2	NUM
admet-2455	311	3	]	]	PUNCT
admet-2455	311	4	i.	i.	PROPN
admet-2455	311	5	martinez	martinez	PROPN
admet-2455	311	6	-	-	PUNCT
admet-2455	311	7	reyes	reyes	PROPN
admet-2455	311	8	,	,	PUNCT
admet-2455	311	9	n.s	n.s	PROPN
admet-2455	311	10	.	.	PROPN
admet-2455	311	11	chandel	chandel	PROPN
admet-2455	311	12	.	.	PUNCT
admet-2455	312	1	cancer	cancer	NOUN
admet-2455	312	2	metabolism	metabolism	NOUN
admet-2455	312	3	:	:	PUNCT
admet-2455	312	4	looking	look	VERB
admet-2455	312	5	forward	forward	ADV
admet-2455	312	6	.	.	PUNCT
admet-2455	313	1	nature	nature	NOUN
admet-2455	313	2	reviews	review	VERB
admet-2455	313	3	cancer	cancer	NOUN
admet-2455	313	4	21	21	NUM
admet-2455	313	5	(	(	PUNCT
admet-2455	313	6	2021	2021	NUM
admet-2455	313	7	)	)	PUNCT
admet-2455	313	8	669	669	NUM
admet-2455	313	9	-	-	SYM
admet-2455	313	10	680	680	NUM
admet-2455	313	11	.	.	PUNCT
admet-2455	314	1	https://doi.org/10.1038/s41568-021-00378-6	https://doi.org/10.1038/s41568-021-00378-6	NUM
admet-2455	314	2	.	.	PUNCT
admet-2455	315	1	[	[	X
admet-2455	315	2	3	3	X
admet-2455	315	3	]	]	X
admet-2455	315	4	n.n	n.n	PROPN
admet-2455	315	5	.	.	PROPN
admet-2455	315	6	pavlova	pavlova	PROPN
admet-2455	315	7	,	,	PUNCT
admet-2455	315	8	j.	j.	PROPN
admet-2455	315	9	zhu	zhu	PROPN
admet-2455	315	10	,	,	PUNCT
admet-2455	315	11	c.b	c.b	PROPN
admet-2455	315	12	.	.	PROPN
admet-2455	315	13	thompson	thompson	PROPN
admet-2455	315	14	.	.	PUNCT
admet-2455	316	1	the	the	DET
admet-2455	316	2	hallmarks	hallmark	NOUN
admet-2455	316	3	of	of	ADP
admet-2455	316	4	cancer	cancer	NOUN
admet-2455	316	5	metabolism	metabolism	NOUN
admet-2455	316	6	:	:	PUNCT
admet-2455	316	7	still	still	ADV
admet-2455	316	8	emerging	emerge	VERB
admet-2455	316	9	.	.	PUNCT
admet-2455	317	1	cell	cell	NOUN
admet-2455	317	2	metab	metab	NOUN
admet-2455	317	3	34	34	NUM
admet-2455	317	4	(	(	PUNCT
admet-2455	317	5	2022	2022	NUM
admet-2455	317	6	)	)	PUNCT
admet-2455	317	7	355	355	NUM
admet-2455	317	8	-	-	SYM
admet-2455	317	9	377	377	NUM
admet-2455	317	10	.	.	PUNCT
admet-2455	318	1	https://doi.org/10.1016/j.cmet.2022.01.007	https://doi.org/10.1016/j.cmet.2022.01.007	NOUN
admet-2455	318	2	.	.	PUNCT
admet-2455	319	1	[	[	X
admet-2455	319	2	4	4	X
admet-2455	319	3	]	]	X
admet-2455	319	4	y.	y.	PROPN
admet-2455	319	5	zhou	zhou	PROPN
admet-2455	319	6	,	,	PUNCT
admet-2455	319	7	y.	y.	PROPN
admet-2455	319	8	guo	guo	PROPN
admet-2455	319	9	,	,	PUNCT
admet-2455	319	10	k.y	k.y	PROPN
admet-2455	319	11	.	.	PROPN
admet-2455	319	12	tam	tam	PROPN
admet-2455	319	13	.	.	PUNCT
admet-2455	319	14	targeting	target	VERB
admet-2455	319	15	glucose	glucose	NOUN
admet-2455	319	16	metabolism	metabolism	NOUN
admet-2455	319	17	to	to	PART
admet-2455	319	18	develop	develop	VERB
admet-2455	319	19	anticancer	anticancer	NOUN
admet-2455	319	20	treatments	treatment	NOUN
admet-2455	319	21	and	and	CCONJ
admet-2455	319	22	therapeutic	therapeutic	ADJ
admet-2455	319	23	patents	patent	NOUN
admet-2455	319	24	.	.	PUNCT
admet-2455	320	1	expert	expert	NOUN
admet-2455	320	2	opin	opin	NOUN
admet-2455	320	3	ther	ther	ADV
admet-2455	320	4	pat	pat	PROPN
admet-2455	320	5	32	32	NUM
admet-2455	320	6	(	(	PUNCT
admet-2455	320	7	2022	2022	NUM
admet-2455	320	8	)	)	PUNCT
admet-2455	320	9	441	441	NUM
admet-2455	320	10	-	-	SYM
admet-2455	320	11	453	453	NUM
admet-2455	320	12	.	.	PUNCT
admet-2455	321	1	https://doi.org/10.1080/13543776.2022.2027912	https://doi.org/10.1080/13543776.2022.2027912	PROPN
admet-2455	321	2	.	.	PUNCT
admet-2455	322	1	[	[	X
admet-2455	322	2	5	5	X
admet-2455	322	3	]	]	PUNCT
admet-2455	322	4	e.	e.	PROPN
admet-2455	322	5	bobrovnikova	bobrovnikova	PROPN
admet-2455	322	6	-	-	PUNCT
admet-2455	322	7	marjon	marjon	NOUN
admet-2455	322	8	,	,	PUNCT
admet-2455	322	9	j.b	j.b	PROPN
admet-2455	322	10	.	.	PUNCT
admet-2455	323	1	hurov	hurov	PROPN
admet-2455	323	2	.	.	PUNCT
admet-2455	324	1	targeting	target	VERB
admet-2455	324	2	metabolic	metabolic	NOUN
admet-2455	324	3	changes	change	NOUN
admet-2455	324	4	in	in	ADP
admet-2455	324	5	cancer	cancer	NOUN
admet-2455	324	6	:	:	PUNCT
admet-2455	324	7	novel	novel	ADJ
admet-2455	324	8	therapeutic	therapeutic	ADJ
admet-2455	324	9	approaches	approach	NOUN
admet-2455	324	10	.	.	PUNCT
admet-2455	325	1	annu	annu	NOUN
admet-2455	325	2	rev	rev	VERB
admet-2455	325	3	med	med	PROPN
admet-2455	325	4	65	65	NUM
admet-2455	325	5	(	(	PUNCT
admet-2455	325	6	2014	2014	NUM
admet-2455	325	7	)	)	PUNCT
admet-2455	325	8	157	157	NUM
admet-2455	325	9	-	-	SYM
admet-2455	325	10	170	170	NUM
admet-2455	325	11	.	.	PUNCT
admet-2455	325	12	https://doi.org/10.1146/annurev-med-092012112344	https://doi.org/10.1146/annurev-med-092012112344	NOUN
admet-2455	325	13	.	.	PUNCT
admet-2455	326	1	[	[	X
admet-2455	326	2	6	6	NUM
admet-2455	326	3	]	]	PUNCT
admet-2455	326	4	r.	r.	PROPN
admet-2455	326	5	li	li	PROPN
admet-2455	326	6	,	,	PUNCT
admet-2455	326	7	s.	s.	PROPN
admet-2455	326	8	mei	mei	PROPN
admet-2455	326	9	,	,	PUNCT
admet-2455	326	10	q.	q.	PROPN
admet-2455	326	11	ding	ding	PROPN
admet-2455	326	12	,	,	PUNCT
admet-2455	326	13	q.	q.	PROPN
admet-2455	326	14	wang	wang	PROPN
admet-2455	326	15	,	,	PUNCT
admet-2455	326	16	l.	l.	PROPN
admet-2455	326	17	yu	yu	PROPN
admet-2455	326	18	,	,	PUNCT
admet-2455	326	19	f.	f.	PROPN
admet-2455	326	20	zi	zi	PROPN
admet-2455	326	21	.	.	PUNCT
admet-2455	327	1	a	a	DET
admet-2455	327	2	pan	pan	ADJ
admet-2455	327	3	-	-	ADJ
admet-2455	327	4	cancer	cancer	NOUN
admet-2455	327	5	analysis	analysis	NOUN
admet-2455	327	6	of	of	ADP
admet-2455	327	7	the	the	DET
admet-2455	327	8	role	role	NOUN
admet-2455	327	9	of	of	ADP
admet-2455	327	10	hexokinase	hexokinase	NOUN
admet-2455	327	11	ii	ii	PROPN
admet-2455	327	12	(	(	PUNCT
admet-2455	327	13	hk2	hk2	PROPN
admet-2455	327	14	)	)	PUNCT
admet-2455	327	15	in	in	ADP
admet-2455	327	16	human	human	ADJ
admet-2455	327	17	tumour	tumour	NOUN
admet-2455	327	18	s.	s.	PROPN
admet-2455	327	19	sci	sci	PROPN
admet-2455	327	20	rep	rep	PROPN
admet-2455	327	21	12	12	NUM
admet-2455	327	22	(	(	PUNCT
admet-2455	327	23	2022	2022	NUM
admet-2455	327	24	)	)	PUNCT
admet-2455	327	25	18807	18807	NUM
admet-2455	327	26	.	.	PUNCT
admet-2455	328	1	https://doi.org/10.1038/s41598-022-23598-8	https://doi.org/10.1038/s41598-022-23598-8	NUM
admet-2455	328	2	.	.	PUNCT
admet-2455	329	1	[	[	X
admet-2455	329	2	7	7	NUM
admet-2455	329	3	]	]	X
admet-2455	329	4	i.	i.	PROPN
admet-2455	329	5	elia	elia	PROPN
admet-2455	329	6	,	,	PUNCT
admet-2455	329	7	m.c	m.c	PROPN
admet-2455	329	8	.	.	PROPN
admet-2455	329	9	haigis	haigis	PROPN
admet-2455	329	10	.	.	PUNCT
admet-2455	330	1	metabolites	metabolite	NOUN
admet-2455	330	2	and	and	CCONJ
admet-2455	330	3	the	the	DET
admet-2455	330	4	tumour	tumour	NOUN
admet-2455	330	5	microenvironment	microenvironment	NOUN
admet-2455	330	6	:	:	PUNCT
admet-2455	330	7	from	from	ADP
admet-2455	330	8	cellular	cellular	ADJ
admet-2455	330	9	mechanisms	mechanism	NOUN
admet-2455	330	10	to	to	ADP
admet-2455	330	11	systemic	systemic	ADJ
admet-2455	330	12	metabolism	metabolism	NOUN
admet-2455	330	13	.	.	PUNCT
admet-2455	331	1	nat	nat	PROPN
admet-2455	331	2	metab	metab	PROPN
admet-2455	331	3	3	3	NUM
admet-2455	331	4	(	(	PUNCT
admet-2455	331	5	2021	2021	NUM
admet-2455	331	6	)	)	PUNCT
admet-2455	331	7	21	21	NUM
admet-2455	331	8	-	-	SYM
admet-2455	331	9	32	32	NUM
admet-2455	331	10	.	.	PUNCT
admet-2455	332	1	https://doi.org/10.1038/s42255-020-00317-z	https://doi.org/10.1038/s42255-020-00317-z	PROPN
admet-2455	332	2	.	.	PUNCT
admet-2455	333	1	[	[	X
admet-2455	333	2	8	8	X
admet-2455	333	3	]	]	PUNCT
admet-2455	333	4	k.	k.	PROPN
admet-2455	333	5	honigova	honigova	PROPN
admet-2455	333	6	,	,	PUNCT
admet-2455	333	7	j.	j.	PROPN
admet-2455	333	8	navratil	navratil	PROPN
admet-2455	333	9	,	,	PUNCT
admet-2455	333	10	b.	b.	PROPN
admet-2455	333	11	peltanova	peltanova	PROPN
admet-2455	333	12	,	,	PUNCT
admet-2455	333	13	h.h	h.h	PROPN
admet-2455	333	14	.	.	PROPN
admet-2455	333	15	polanska	polanska	PROPN
admet-2455	333	16	,	,	PUNCT
admet-2455	333	17	m.	m.	NOUN
admet-2455	333	18	raudenska	raudenska	PROPN
admet-2455	333	19	,	,	PUNCT
admet-2455	333	20	m.	m.	NOUN
admet-2455	333	21	masarik	masarik	PROPN
admet-2455	333	22	.	.	PUNCT
admet-2455	334	1	metabolic	metabolic	NOUN
admet-2455	334	2	tricks	trick	NOUN
admet-2455	334	3	of	of	ADP
admet-2455	334	4	cancer	cancer	NOUN
admet-2455	334	5	cells	cell	NOUN
admet-2455	334	6	.	.	PUNCT
admet-2455	335	1	biochim	biochim	PROPN
admet-2455	335	2	biophys	biophys	PROPN
admet-2455	335	3	acta	acta	PROPN
admet-2455	335	4	rev	rev	VERB
admet-2455	335	5	cancer	cancer	PROPN
admet-2455	335	6	1877	1877	PROPN
admet-2455	335	7	(	(	PUNCT
admet-2455	335	8	2022	2022	NUM
admet-2455	335	9	)	)	PUNCT
admet-2455	335	10	188705	188705	NUM
admet-2455	335	11	.	.	PUNCT
admet-2455	336	1	https://doi.org/10.1016/j.bbcan.2022.188705	https://doi.org/10.1016/j.bbcan.2022.188705	NOUN
admet-2455	336	2	.	.	PUNCT
admet-2455	337	1	[	[	X
admet-2455	337	2	9	9	NUM
admet-2455	337	3	]	]	X
admet-2455	337	4	w.	w.	PROPN
admet-2455	337	5	shan	shan	PROPN
admet-2455	337	6	,	,	PUNCT
admet-2455	337	7	y.	y.	PROPN
admet-2455	337	8	zhou	zhou	PROPN
admet-2455	337	9	,	,	PUNCT
admet-2455	337	10	k.y	k.y	PROPN
admet-2455	337	11	.	.	PROPN
admet-2455	337	12	tam	tam	PROPN
admet-2455	337	13	.	.	PUNCT
admet-2455	338	1	the	the	DET
admet-2455	338	2	development	development	NOUN
admet-2455	338	3	of	of	ADP
admet-2455	338	4	small	small	ADJ
admet-2455	338	5	-	-	PUNCT
admet-2455	338	6	molecule	molecule	NOUN
admet-2455	338	7	inhibitors	inhibitor	NOUN
admet-2455	338	8	targeting	target	VERB
admet-2455	338	9	hexokinase	hexokinase	NOUN
admet-2455	338	10	2	2	NUM
admet-2455	338	11	.	.	PUNCT
admet-2455	338	12	drug	drug	NOUN
admet-2455	338	13	discov	discov	PROPN
admet-2455	338	14	today	today	NOUN
admet-2455	338	15	27	27	NUM
admet-2455	338	16	(	(	PUNCT
admet-2455	338	17	2022	2022	NUM
admet-2455	338	18	)	)	PUNCT
admet-2455	338	19	2574	2574	NUM
admet-2455	338	20	-	-	SYM
admet-2455	338	21	2585	2585	NUM
admet-2455	338	22	.	.	PUNCT
admet-2455	339	1	https://doi.org/10.1016/j.drudis.2022.05.017	https://doi.org/10.1016/j.drudis.2022.05.017	NOUN
admet-2455	339	2	.	.	X
admet-2455	340	1	https://doi.org/10.1016/j.cell.2009.02.024	https://doi.org/10.1016/j.cell.2009.02.024	VERB
admet-2455	340	2	https://doi.org/10.1038/s41568-021-00378-6	https://doi.org/10.1038/s41568-021-00378-6	NUM
admet-2455	340	3	https://doi.org/10.1016/j.cmet.2022.01.007	https://doi.org/10.1016/j.cmet.2022.01.007	PROPN
admet-2455	340	4	https://doi.org/10.1080/13543776.2022.2027912	https://doi.org/10.1080/13543776.2022.2027912	PUNCT
admet-2455	340	5	https://doi.org/10.1146/annurev-med-092012-112344	https://doi.org/10.1146/annurev-med-092012-112344	NOUN
admet-2455	340	6	https://doi.org/10.1146/annurev-med-092012-112344	https://doi.org/10.1146/annurev-med-092012-112344	VERB
admet-2455	340	7	https://doi.org/10.1038/s41598-022-23598-8	https://doi.org/10.1038/s41598-022-23598-8	NUM
admet-2455	340	8	https://doi.org/10.1038/s42255-020-00317-z	https://doi.org/10.1038/s42255-020-00317-z	PROPN
admet-2455	340	9	https://doi.org/10.1016/j.bbcan.2022.188705	https://doi.org/10.1016/j.bbcan.2022.188705	VERB
admet-2455	340	10	https://doi.org/10.1016/j.drudis.2022.05.017	https://doi.org/10.1016/j.drudis.2022.05.017	PROPN
admet-2455	340	11	admet	admet	PROPN
admet-2455	340	12	&	&	CCONJ
admet-2455	340	13	dmpk	dmpk	PROPN
admet-2455	340	14	12(6	12(6	NUM
admet-2455	340	15	)	)	PUNCT
admet-2455	340	16	(	(	PUNCT
admet-2455	340	17	2024	2024	NUM
admet-2455	340	18	)	)	PUNCT
admet-2455	340	19	821	821	NUM
admet-2455	340	20	-	-	SYM
admet-2455	340	21	841	841	NUM
admet-2455	340	22	targeting	targeting	NOUN
admet-2455	340	23	hexokinase	hexokinase	NOUN
admet-2455	340	24	2	2	NUM
admet-2455	340	25	to	to	PART
admet-2455	340	26	enhance	enhance	VERB
admet-2455	340	27	anticancer	anticancer	NOUN
admet-2455	340	28	efficacy	efficacy	NOUN
admet-2455	340	29	of	of	ADP
admet-2455	340	30	trichosanthin	trichosanthin	PROPN
admet-2455	340	31	doi	doi	PROPN
admet-2455	340	32	:	:	PUNCT
admet-2455	340	33	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PRON
admet-2455	340	34	839	839	NUM
admet-2455	340	35	[	[	SYM
admet-2455	340	36	10	10	NUM
admet-2455	340	37	]	]	X
admet-2455	340	38	z.e	z.e	PROPN
admet-2455	340	39	.	.	PROPN
admet-2455	340	40	stine	stine	PROPN
admet-2455	340	41	,	,	PUNCT
admet-2455	340	42	z.t	z.t	PROPN
admet-2455	340	43	.	.	PROPN
admet-2455	340	44	schug	schug	PROPN
admet-2455	340	45	,	,	PUNCT
admet-2455	340	46	j.m	j.m	PROPN
admet-2455	340	47	.	.	PROPN
admet-2455	340	48	salvino	salvino	PROPN
admet-2455	340	49	,	,	PUNCT
admet-2455	340	50	c.v	c.v	PROPN
admet-2455	340	51	.	.	PROPN
admet-2455	340	52	dang	dang	PROPN
admet-2455	340	53	.	.	PUNCT
admet-2455	341	1	targeting	target	VERB
admet-2455	341	2	cancer	cancer	NOUN
admet-2455	341	3	metabolism	metabolism	NOUN
admet-2455	341	4	in	in	ADP
admet-2455	341	5	the	the	DET
admet-2455	341	6	era	era	NOUN
admet-2455	341	7	of	of	ADP
admet-2455	341	8	precision	precision	NOUN
admet-2455	341	9	oncology	oncology	NOUN
admet-2455	341	10	.	.	PUNCT
admet-2455	342	1	nat	nat	PROPN
admet-2455	342	2	rev	rev	PROPN
admet-2455	342	3	drug	drug	PROPN
admet-2455	342	4	discov	discov	PROPN
admet-2455	342	5	21	21	NUM
admet-2455	342	6	(	(	PUNCT
admet-2455	342	7	2022	2022	NUM
admet-2455	342	8	)	)	PUNCT
admet-2455	342	9	141	141	NUM
admet-2455	342	10	-	-	SYM
admet-2455	342	11	162	162	NUM
admet-2455	342	12	.	.	PUNCT
admet-2455	342	13	https://doi.org/10.1038/s41573-021-00339-6	https://doi.org/10.1038/s41573-021-00339-6	NUM
admet-2455	342	14	.	.	PUNCT
admet-2455	343	1	[	[	X
admet-2455	343	2	11	11	NUM
admet-2455	343	3	]	]	X
admet-2455	343	4	s.r	s.r	PROPN
admet-2455	343	5	.	.	PROPN
admet-2455	343	6	lin	lin	PROPN
admet-2455	343	7	,	,	PUNCT
admet-2455	343	8	c.h	c.h	PROPN
admet-2455	343	9	.	.	PROPN
admet-2455	343	10	chang	chang	PROPN
admet-2455	343	11	,	,	PUNCT
admet-2455	343	12	c.f	c.f	PROPN
admet-2455	343	13	.	.	PROPN
admet-2455	343	14	hsu	hsu	PROPN
admet-2455	343	15	,	,	PUNCT
admet-2455	343	16	m.j	m.j	PROPN
admet-2455	343	17	.	.	PROPN
admet-2455	343	18	tsai	tsai	PROPN
admet-2455	343	19	,	,	PUNCT
admet-2455	343	20	h.	h.	PROPN
admet-2455	343	21	cheng	cheng	PROPN
admet-2455	343	22	,	,	PUNCT
admet-2455	343	23	m.k	m.k	PROPN
admet-2455	343	24	.	.	PUNCT
admet-2455	343	25	leong	leong	PROPN
admet-2455	343	26	,	,	PUNCT
admet-2455	343	27	p.j	p.j	PROPN
admet-2455	343	28	.	.	PROPN
admet-2455	343	29	sung	sung	PROPN
admet-2455	343	30	,	,	PUNCT
admet-2455	343	31	j.c	j.c	PROPN
admet-2455	343	32	.	.	PROPN
admet-2455	343	33	chen	chen	PROPN
admet-2455	343	34	,	,	PUNCT
admet-2455	343	35	c.f	c.f	PROPN
admet-2455	343	36	.	.	PROPN
admet-2455	343	37	weng	weng	PROPN
admet-2455	343	38	.	.	PUNCT
admet-2455	344	1	natural	natural	ADJ
admet-2455	344	2	compounds	compound	NOUN
admet-2455	344	3	as	as	ADP
admet-2455	344	4	potential	potential	ADJ
admet-2455	344	5	adjuvants	adjuvant	NOUN
admet-2455	344	6	to	to	ADP
admet-2455	344	7	cancer	cancer	NOUN
admet-2455	344	8	therapy	therapy	NOUN
admet-2455	344	9	:	:	PUNCT
admet-2455	344	10	preclinical	preclinical	ADJ
admet-2455	344	11	evidence	evidence	NOUN
admet-2455	344	12	.	.	PUNCT
admet-2455	345	1	br	br	X
admet-2455	346	1	j	j	PROPN
admet-2455	346	2	pharmacol	pharmacol	PROPN
admet-2455	346	3	177	177	NUM
admet-2455	346	4	(	(	PUNCT
admet-2455	346	5	2020	2020	NUM
admet-2455	346	6	)	)	PUNCT
admet-2455	346	7	1409	1409	NUM
admet-2455	346	8	-	-	SYM
admet-2455	346	9	1423	1423	NUM
admet-2455	346	10	.	.	PUNCT
admet-2455	347	1	https://doi.org/10.1111/bph.14816	https://doi.org/10.1111/bph.14816	PROPN
admet-2455	347	2	.	.	PUNCT
admet-2455	348	1	[	[	X
admet-2455	348	2	12	12	NUM
admet-2455	348	3	]	]	PUNCT
admet-2455	348	4	m.	m.	PROPN
admet-2455	348	5	huang	huang	PROPN
admet-2455	348	6	,	,	PUNCT
admet-2455	348	7	j.j	j.j	PROPN
admet-2455	348	8	.	.	PROPN
admet-2455	348	9	lu	lu	PROPN
admet-2455	348	10	,	,	PUNCT
admet-2455	348	11	j.	j.	PROPN
admet-2455	348	12	ding	ding	PROPN
admet-2455	348	13	.	.	PUNCT
admet-2455	348	14	natural	natural	ADJ
admet-2455	348	15	products	product	NOUN
admet-2455	348	16	in	in	ADP
admet-2455	348	17	cancer	cancer	NOUN
admet-2455	348	18	therapy	therapy	NOUN
admet-2455	348	19	:	:	PUNCT
admet-2455	348	20	past	past	ADJ
admet-2455	348	21	,	,	PUNCT
admet-2455	348	22	present	present	ADJ
admet-2455	348	23	and	and	CCONJ
admet-2455	348	24	future	future	NOUN
admet-2455	348	25	.	.	PUNCT
admet-2455	349	1	nat	nat	PROPN
admet-2455	349	2	prod	prod	PROPN
admet-2455	349	3	bioprospect	bioprospect	NOUN
admet-2455	349	4	11	11	NUM
admet-2455	349	5	(	(	PUNCT
admet-2455	349	6	2021	2021	NUM
admet-2455	349	7	)	)	PUNCT
admet-2455	349	8	5	5	NUM
admet-2455	349	9	-	-	SYM
admet-2455	349	10	13	13	NUM
admet-2455	349	11	.	.	PUNCT
admet-2455	350	1	https://doi.org/10.1007/s13659-020-00293-7	https://doi.org/10.1007/s13659-020-00293-7	PRON
admet-2455	350	2	.	.	PUNCT
admet-2455	351	1	[	[	X
admet-2455	351	2	13	13	NUM
admet-2455	351	3	]	]	X
admet-2455	351	4	p.c	p.c	PROPN
admet-2455	351	5	.	.	PROPN
admet-2455	351	6	shaw	shaw	PROPN
admet-2455	351	7	,	,	PUNCT
admet-2455	351	8	w.l	w.l	PROPN
admet-2455	351	9	.	.	PROPN
admet-2455	351	10	chan	chan	PROPN
admet-2455	351	11	,	,	PUNCT
admet-2455	351	12	h.w	h.w	PROPN
admet-2455	351	13	.	.	PROPN
admet-2455	351	14	yeung	yeung	PROPN
admet-2455	351	15	,	,	PUNCT
admet-2455	351	16	t.b	t.b	PROPN
admet-2455	351	17	.	.	PROPN
admet-2455	351	18	ng	ng	PROPN
admet-2455	351	19	.	.	PROPN
admet-2455	351	20	minireview	minireview	PROPN
admet-2455	351	21	:	:	PUNCT
admet-2455	351	22	trichosanthin	trichosanthin	PROPN
admet-2455	351	23	--	--	PUNCT
admet-2455	351	24	a	a	DET
admet-2455	351	25	protein	protein	NOUN
admet-2455	351	26	with	with	ADP
admet-2455	351	27	multiple	multiple	ADJ
admet-2455	351	28	pharmacological	pharmacological	ADJ
admet-2455	351	29	properties	property	NOUN
admet-2455	351	30	.	.	PUNCT
admet-2455	352	1	life	life	NOUN
admet-2455	352	2	sci	sci	PROPN
admet-2455	352	3	55	55	NUM
admet-2455	352	4	(	(	PUNCT
admet-2455	352	5	1994	1994	NUM
admet-2455	352	6	)	)	PUNCT
admet-2455	352	7	253	253	NUM
admet-2455	352	8	-	-	SYM
admet-2455	352	9	262	262	NUM
admet-2455	352	10	.	.	PUNCT
admet-2455	353	1	https://doi.org/10.1016/00243205(94)00727-6	https://doi.org/10.1016/00243205(94)00727-6	PROPN
admet-2455	353	2	.	.	PUNCT
admet-2455	354	1	[	[	X
admet-2455	354	2	14	14	NUM
admet-2455	354	3	]	]	X
admet-2455	354	4	o.	o.	PROPN
admet-2455	354	5	sha	sha	PROPN
admet-2455	354	6	,	,	PUNCT
admet-2455	354	7	j.	j.	PROPN
admet-2455	354	8	niu	niu	PROPN
admet-2455	354	9	,	,	PUNCT
admet-2455	354	10	t.b	t.b	PROPN
admet-2455	354	11	.	.	PROPN
admet-2455	354	12	ng	ng	PROPN
admet-2455	354	13	,	,	PUNCT
admet-2455	354	14	e.y	e.y	PROPN
admet-2455	354	15	.	.	PROPN
admet-2455	354	16	cho	cho	PROPN
admet-2455	354	17	,	,	PUNCT
admet-2455	354	18	x.	x.	PROPN
admet-2455	354	19	fu	fu	PROPN
admet-2455	354	20	,	,	PUNCT
admet-2455	354	21	w.	w.	PROPN
admet-2455	354	22	jiang	jiang	PROPN
admet-2455	354	23	.	.	PUNCT
admet-2455	355	1	antitumour	antitumour	PROPN
admet-2455	355	2	action	action	NOUN
admet-2455	355	3	of	of	ADP
admet-2455	355	4	trichosanthin	trichosanthin	PROPN
admet-2455	355	5	,	,	PUNCT
admet-2455	355	6	a	a	DET
admet-2455	355	7	type	type	NOUN
admet-2455	355	8	1	1	NUM
admet-2455	355	9	ribosome	ribosome	NOUN
admet-2455	355	10	-	-	PUNCT
admet-2455	355	11	inactivating	inactivate	VERB
admet-2455	355	12	protein	protein	NOUN
admet-2455	355	13	,	,	PUNCT
admet-2455	355	14	employed	employ	VERB
admet-2455	355	15	in	in	ADP
admet-2455	355	16	traditional	traditional	ADJ
admet-2455	355	17	chinese	chinese	ADJ
admet-2455	355	18	medicine	medicine	NOUN
admet-2455	355	19	:	:	PUNCT
admet-2455	355	20	a	a	DET
admet-2455	355	21	mini	mini	ADJ
admet-2455	355	22	review	review	NOUN
admet-2455	355	23	.	.	PUNCT
admet-2455	356	1	cancer	cancer	NOUN
admet-2455	356	2	chemother	chemother	PROPN
admet-2455	356	3	pharmacol	pharmacol	PROPN
admet-2455	356	4	71	71	NUM
admet-2455	356	5	(	(	PUNCT
admet-2455	356	6	2013	2013	NUM
admet-2455	356	7	)	)	PUNCT
admet-2455	356	8	1387	1387	NUM
admet-2455	356	9	-	-	SYM
admet-2455	356	10	1393	1393	NUM
admet-2455	356	11	.	.	PUNCT
admet-2455	357	1	https://doi.org/10.1007/s00280-013-2096-y	https://doi.org/10.1007/s00280-013-2096-y	NOUN
admet-2455	357	2	.	.	PUNCT
admet-2455	358	1	[	[	X
admet-2455	358	2	15	15	NUM
admet-2455	358	3	]	]	X
admet-2455	358	4	w.w	w.w	PROPN
admet-2455	358	5	.	.	PROPN
admet-2455	358	6	shi	shi	PROPN
admet-2455	358	7	,	,	PUNCT
admet-2455	358	8	k.b	k.b	PROPN
admet-2455	358	9	.	.	PROPN
admet-2455	358	10	wong	wong	PROPN
admet-2455	358	11	,	,	PUNCT
admet-2455	358	12	p.c	p.c	PROPN
admet-2455	358	13	.	.	PROPN
admet-2455	358	14	shaw	shaw	PROPN
admet-2455	358	15	.	.	PROPN
admet-2455	359	1	structural	structural	ADJ
admet-2455	359	2	and	and	CCONJ
admet-2455	359	3	functional	functional	ADJ
admet-2455	359	4	investigation	investigation	NOUN
admet-2455	359	5	and	and	CCONJ
admet-2455	359	6	pharmacological	pharmacological	ADJ
admet-2455	359	7	mechanism	mechanism	NOUN
admet-2455	359	8	of	of	ADP
admet-2455	359	9	trichosanthin	trichosanthin	PROPN
admet-2455	359	10	,	,	PUNCT
admet-2455	359	11	a	a	DET
admet-2455	359	12	type	type	NOUN
admet-2455	359	13	1	1	NUM
admet-2455	359	14	ribosome	ribosome	NOUN
admet-2455	359	15	-	-	PUNCT
admet-2455	359	16	inactivating	inactivate	VERB
admet-2455	359	17	protein	protein	NOUN
admet-2455	359	18	.	.	PUNCT
admet-2455	360	1	toxins	toxin	NOUN
admet-2455	360	2	(	(	PUNCT
admet-2455	360	3	basel	basel	PROPN
admet-2455	360	4	)	)	PUNCT
admet-2455	360	5	10	10	NUM
admet-2455	360	6	(	(	PUNCT
admet-2455	360	7	2018	2018	NUM
admet-2455	360	8	)	)	PUNCT
admet-2455	360	9	335	335	NUM
admet-2455	360	10	.	.	PUNCT
admet-2455	360	11	https://doi.org/10.3390/toxins10080335	https://doi.org/10.3390/toxins10080335	NOUN
admet-2455	360	12	.	.	PUNCT
admet-2455	361	1	[	[	X
admet-2455	361	2	16	16	NUM
admet-2455	361	3	]	]	X
admet-2455	361	4	y.	y.	PROPN
admet-2455	361	5	tan	tan	PROPN
admet-2455	361	6	,	,	PUNCT
admet-2455	361	7	j.	j.	PROPN
admet-2455	361	8	xiang	xiang	PROPN
admet-2455	361	9	,	,	PUNCT
admet-2455	361	10	z.	z.	PROPN
admet-2455	361	11	huang	huang	PROPN
admet-2455	361	12	,	,	PUNCT
admet-2455	361	13	l.	l.	PROPN
admet-2455	361	14	wang	wang	PROPN
admet-2455	361	15	,	,	PUNCT
admet-2455	361	16	y.	y.	PROPN
admet-2455	361	17	huang	huang	PROPN
admet-2455	361	18	.	.	PROPN
admet-2455	362	1	trichosanthin	trichosanthin	PROPN
admet-2455	362	2	inhibits	inhibit	VERB
admet-2455	362	3	cell	cell	NOUN
admet-2455	362	4	growth	growth	NOUN
admet-2455	362	5	and	and	CCONJ
admet-2455	362	6	metastasis	metastasis	NOUN
admet-2455	362	7	by	by	ADP
admet-2455	362	8	promoting	promote	VERB
admet-2455	362	9	pyroptosis	pyroptosis	NOUN
admet-2455	362	10	in	in	ADP
admet-2455	362	11	non	non	ADJ
admet-2455	362	12	-	-	ADJ
admet-2455	362	13	small	small	ADJ
admet-2455	362	14	cell	cell	NOUN
admet-2455	362	15	lung	lung	NOUN
admet-2455	362	16	cancer	cancer	NOUN
admet-2455	362	17	.	.	PUNCT
admet-2455	363	1	j	j	PROPN
admet-2455	363	2	thorac	thorac	PROPN
admet-2455	363	3	dis	dis	PROPN
admet-2455	363	4	14	14	NUM
admet-2455	363	5	(	(	PUNCT
admet-2455	363	6	2022	2022	NUM
admet-2455	363	7	)	)	PUNCT
admet-2455	363	8	1193	1193	NUM
admet-2455	363	9	-	-	SYM
admet-2455	363	10	1202	1202	NUM
admet-2455	363	11	.	.	PUNCT
admet-2455	364	1	https://doi.org/10.21037/jtd-22-282	https://doi.org/10.21037/jtd-22-282	PROPN
admet-2455	364	2	.	.	PUNCT
admet-2455	365	1	[	[	X
admet-2455	365	2	17	17	NUM
admet-2455	365	3	]	]	X
admet-2455	365	4	e.f	e.f	PROPN
admet-2455	365	5	.	.	PROPN
admet-2455	365	6	fang	fang	PROPN
admet-2455	365	7	,	,	PUNCT
admet-2455	365	8	c.z	c.z	PROPN
admet-2455	365	9	.	.	PROPN
admet-2455	365	10	zhang	zhang	PROPN
admet-2455	365	11	,	,	PUNCT
admet-2455	365	12	l.	l.	PROPN
admet-2455	365	13	zhang	zhang	PROPN
admet-2455	365	14	,	,	PUNCT
admet-2455	365	15	j.h	j.h	PROPN
admet-2455	365	16	.	.	PROPN
admet-2455	365	17	wong	wong	PROPN
admet-2455	365	18	,	,	PUNCT
admet-2455	365	19	y.s	y.s	PROPN
admet-2455	365	20	.	.	PROPN
admet-2455	365	21	chan	chan	PROPN
admet-2455	365	22	,	,	PUNCT
admet-2455	365	23	w.l	w.l	PROPN
admet-2455	365	24	.	.	PROPN
admet-2455	365	25	pan	pan	PROPN
admet-2455	365	26	,	,	PUNCT
admet-2455	365	27	x.l	x.l	PROPN
admet-2455	365	28	.	.	PROPN
admet-2455	365	29	dan	dan	PROPN
admet-2455	365	30	,	,	PUNCT
admet-2455	365	31	c.m	c.m	PROPN
admet-2455	365	32	.	.	PROPN
admet-2455	365	33	yin	yin	PROPN
admet-2455	365	34	,	,	PUNCT
admet-2455	365	35	c.h	c.h	PROPN
admet-2455	365	36	.	.	PROPN
admet-2455	365	37	cho	cho	PROPN
admet-2455	365	38	,	,	PUNCT
admet-2455	365	39	t.b	t.b	PROPN
admet-2455	365	40	.	.	PROPN
admet-2455	365	41	ng	ng	PROPN
admet-2455	365	42	.	.	PROPN
admet-2455	365	43	trichosanthin	trichosanthin	PROPN
admet-2455	365	44	inhibits	inhibit	VERB
admet-2455	365	45	breast	breast	NOUN
admet-2455	365	46	cancer	cancer	NOUN
admet-2455	365	47	cell	cell	NOUN
admet-2455	365	48	proliferation	proliferation	NOUN
admet-2455	365	49	in	in	ADP
admet-2455	365	50	both	both	DET
admet-2455	365	51	cell	cell	NOUN
admet-2455	365	52	lines	line	NOUN
admet-2455	365	53	and	and	CCONJ
admet-2455	365	54	nude	nude	ADJ
admet-2455	365	55	mice	mice	NOUN
admet-2455	365	56	by	by	ADP
admet-2455	365	57	promotion	promotion	NOUN
admet-2455	365	58	of	of	ADP
admet-2455	365	59	apoptosis	apoptosis	NOUN
admet-2455	365	60	.	.	PUNCT
admet-2455	366	1	plos	plos	PROPN
admet-2455	366	2	one	one	NUM
admet-2455	366	3	7	7	NUM
admet-2455	366	4	(	(	PUNCT
admet-2455	366	5	2012	2012	NUM
admet-2455	366	6	)	)	PUNCT
admet-2455	366	7	e41592	e41592	PROPN
admet-2455	366	8	.	.	PUNCT
admet-2455	367	1	https://doi.org/10.1371/journal.pone.0041592	https://doi.org/10.1371/journal.pone.0041592	PROPN
admet-2455	367	2	.	.	PUNCT
admet-2455	368	1	[	[	X
admet-2455	368	2	18	18	NUM
admet-2455	368	3	]	]	PUNCT
admet-2455	368	4	k.	k.	PROPN
admet-2455	368	5	wang	wang	PROPN
admet-2455	368	6	,	,	PUNCT
admet-2455	368	7	x.	x.	PROPN
admet-2455	368	8	wang	wang	PROPN
admet-2455	368	9	,	,	PUNCT
admet-2455	368	10	m.	m.	PROPN
admet-2455	368	11	zhang	zhang	PROPN
admet-2455	368	12	,	,	PUNCT
admet-2455	368	13	z.	z.	PROPN
admet-2455	368	14	ying	ying	PROPN
admet-2455	368	15	,	,	PUNCT
admet-2455	368	16	z.	z.	PROPN
admet-2455	368	17	zhu	zhu	PROPN
admet-2455	368	18	,	,	PUNCT
admet-2455	368	19	k.y	k.y	PROPN
admet-2455	368	20	.	.	PROPN
admet-2455	368	21	tam	tam	PROPN
admet-2455	368	22	,	,	PUNCT
admet-2455	368	23	c.	c.	PROPN
admet-2455	368	24	li	li	PROPN
admet-2455	368	25	,	,	PUNCT
admet-2455	368	26	g.	g.	PROPN
admet-2455	368	27	zhou	zhou	PROPN
admet-2455	368	28	,	,	PUNCT
admet-2455	368	29	f.	f.	PROPN
admet-2455	368	30	gao	gao	PROPN
admet-2455	368	31	,	,	PUNCT
admet-2455	368	32	m.	m.	PROPN
admet-2455	368	33	zeng	zeng	PROPN
admet-2455	368	34	,	,	PUNCT
admet-2455	368	35	s.c.w	s.c.w	PROPN
admet-2455	368	36	.	.	PUNCT
admet-2455	369	1	sze	sze	PROPN
admet-2455	369	2	,	,	PUNCT
admet-2455	369	3	x.	x.	PROPN
admet-2455	369	4	wang	wang	PROPN
admet-2455	369	5	,	,	PUNCT
admet-2455	369	6	o.	o.	PROPN
admet-2455	369	7	sha	sha	PROPN
admet-2455	369	8	.	.	PUNCT
admet-2455	370	1	trichosanthin	trichosanthin	PROPN
admet-2455	370	2	promotes	promote	VERB
admet-2455	370	3	antitumour	antitumour	NOUN
admet-2455	370	4	immunity	immunity	NOUN
admet-2455	370	5	through	through	ADP
admet-2455	370	6	mediating	mediate	VERB
admet-2455	370	7	chemokines	chemokine	NOUN
admet-2455	370	8	and	and	CCONJ
admet-2455	370	9	granzyme	granzyme	NOUN
admet-2455	370	10	b	b	PROPN
admet-2455	370	11	secretion	secretion	NOUN
admet-2455	370	12	in	in	ADP
admet-2455	370	13	hepatocellular	hepatocellular	ADJ
admet-2455	370	14	carcinoma	carcinoma	NOUN
admet-2455	370	15	.	.	PUNCT
admet-2455	371	1	int	int	PROPN
admet-2455	371	2	j	j	PROPN
admet-2455	371	3	mol	mol	ADP
admet-2455	371	4	sci	sci	PROPN
admet-2455	371	5	24	24	NUM
admet-2455	371	6	(	(	PUNCT
admet-2455	371	7	2023	2023	NUM
admet-2455	371	8	)	)	PUNCT
admet-2455	371	9	1416	1416	NUM
admet-2455	371	10	.	.	PUNCT
admet-2455	372	1	https://doi.org/10.3390/ijms24021416	https://doi.org/10.3390/ijms24021416	PROPN
admet-2455	372	2	.	.	PUNCT
admet-2455	373	1	[	[	X
admet-2455	373	2	19	19	NUM
admet-2455	373	3	]	]	X
admet-2455	373	4	f.	f.	PROPN
admet-2455	373	5	li	li	PROPN
admet-2455	373	6	,	,	PUNCT
admet-2455	373	7	y.	y.	PROPN
admet-2455	373	8	mei	mei	PROPN
admet-2455	373	9	,	,	PUNCT
admet-2455	373	10	y.	y.	PROPN
admet-2455	373	11	wang	wang	PROPN
admet-2455	373	12	,	,	PUNCT
admet-2455	373	13	c.	c.	PROPN
admet-2455	373	14	chen	chen	PROPN
admet-2455	373	15	,	,	PUNCT
admet-2455	373	16	j.	j.	PROPN
admet-2455	373	17	tu	tu	PROPN
admet-2455	373	18	,	,	PUNCT
admet-2455	373	19	b.	b.	PROPN
admet-2455	373	20	xiao	xiao	PROPN
admet-2455	373	21	,	,	PUNCT
admet-2455	373	22	l.	l.	PROPN
admet-2455	373	23	xu	xu	PROPN
admet-2455	373	24	.	.	PUNCT
admet-2455	374	1	trichosanthin	trichosanthin	PROPN
admet-2455	374	2	inhibits	inhibit	VERB
admet-2455	374	3	antigen	antigen	ADV
admet-2455	374	4	-	-	PUNCT
admet-2455	374	5	specific	specific	ADJ
admet-2455	374	6	t	t	NOUN
admet-2455	374	7	cell	cell	NOUN
admet-2455	374	8	expansion	expansion	NOUN
admet-2455	374	9	through	through	ADP
admet-2455	374	10	nitric	nitric	ADJ
admet-2455	374	11	oxide	oxide	NOUN
admet-2455	374	12	-	-	PUNCT
admet-2455	374	13	mediated	mediate	VERB
admet-2455	374	14	apoptosis	apoptosis	NOUN
admet-2455	374	15	pathway	pathway	NOUN
admet-2455	374	16	.	.	PUNCT
admet-2455	375	1	cell	cell	NOUN
admet-2455	375	2	immunol	immunol	NOUN
admet-2455	375	3	234	234	NUM
admet-2455	375	4	(	(	PUNCT
admet-2455	375	5	2005	2005	NUM
admet-2455	375	6	)	)	PUNCT
admet-2455	375	7	23	23	NUM
admet-2455	375	8	-	-	SYM
admet-2455	375	9	30	30	NUM
admet-2455	375	10	.	.	PUNCT
admet-2455	376	1	https://doi.org/10.1016/j.cellimm.2005.04.015	https://doi.org/10.1016/j.cellimm.2005.04.015	X
admet-2455	376	2	.	.	PUNCT
admet-2455	377	1	[	[	X
admet-2455	377	2	20	20	NUM
admet-2455	377	3	]	]	X
admet-2455	377	4	j.q	j.q	PROPN
admet-2455	377	5	.	.	PROPN
admet-2455	377	6	lu	lu	PROPN
admet-2455	377	7	,	,	PUNCT
admet-2455	377	8	k.b	k.b	PROPN
admet-2455	377	9	.	.	PROPN
admet-2455	377	10	wong	wong	PROPN
admet-2455	377	11	,	,	PUNCT
admet-2455	377	12	p.c	p.c	PROPN
admet-2455	377	13	.	.	PROPN
admet-2455	377	14	shaw	shaw	PROPN
admet-2455	377	15	.	.	PUNCT
admet-2455	378	1	a	a	DET
admet-2455	378	2	sixty	sixty	NUM
admet-2455	378	3	-	-	PUNCT
admet-2455	378	4	year	year	NOUN
admet-2455	378	5	research	research	NOUN
admet-2455	378	6	and	and	CCONJ
admet-2455	378	7	development	development	NOUN
admet-2455	378	8	of	of	ADP
admet-2455	378	9	trichosanthin	trichosanthin	PROPN
admet-2455	378	10	,	,	PUNCT
admet-2455	378	11	a	a	DET
admet-2455	378	12	ribosome	ribosome	NOUN
admet-2455	378	13	-	-	PUNCT
admet-2455	378	14	inactivating	inactivate	VERB
admet-2455	378	15	protein	protein	NOUN
admet-2455	378	16	.	.	PUNCT
admet-2455	379	1	toxins	toxin	NOUN
admet-2455	379	2	14	14	NUM
admet-2455	379	3	(	(	PUNCT
admet-2455	379	4	2022	2022	NUM
admet-2455	379	5	)	)	PUNCT
admet-2455	379	6	1416	1416	NUM
admet-2455	379	7	.	.	PUNCT
admet-2455	380	1	https://doi.org/10.3390/toxins14030178	https://doi.org/10.3390/toxins14030178	PROPN
admet-2455	380	2	.	.	PUNCT
admet-2455	381	1	[	[	X
admet-2455	381	2	21	21	NUM
admet-2455	381	3	]	]	X
admet-2455	381	4	y.	y.	PROPN
admet-2455	381	5	chen	chen	PROPN
admet-2455	381	6	,	,	PUNCT
admet-2455	381	7	m.	m.	PROPN
admet-2455	381	8	zhang	zhang	PROPN
admet-2455	381	9	,	,	PUNCT
admet-2455	381	10	h.	h.	PROPN
admet-2455	381	11	jin	jin	PROPN
admet-2455	381	12	,	,	PUNCT
admet-2455	381	13	y.	y.	PROPN
admet-2455	381	14	tang	tang	PROPN
admet-2455	381	15	,	,	PUNCT
admet-2455	381	16	h.	h.	PROPN
admet-2455	381	17	wang	wang	PROPN
admet-2455	381	18	,	,	PUNCT
admet-2455	381	19	q.	q.	PROPN
admet-2455	381	20	xu	xu	PROPN
admet-2455	381	21	,	,	PUNCT
admet-2455	381	22	y.	y.	PROPN
admet-2455	381	23	li	li	PROPN
admet-2455	381	24	,	,	PUNCT
admet-2455	381	25	f.	f.	PROPN
admet-2455	381	26	li	li	PROPN
admet-2455	381	27	,	,	PUNCT
admet-2455	381	28	y.	y.	PROPN
admet-2455	381	29	huang	huang	PROPN
admet-2455	381	30	.	.	PUNCT
admet-2455	381	31	intein	intein	ADV
admet-2455	381	32	-	-	PUNCT
admet-2455	381	33	mediated	mediate	VERB
admet-2455	381	34	site	site	NOUN
admet-2455	381	35	-	-	PUNCT
admet-2455	381	36	specific	specific	ADJ
admet-2455	381	37	synthesis	synthesis	NOUN
admet-2455	381	38	of	of	ADP
admet-2455	381	39	tumour	tumour	NOUN
admet-2455	381	40	-targeting	-targete	VERB
admet-2455	381	41	protein	protein	NOUN
admet-2455	381	42	delivery	delivery	NOUN
admet-2455	381	43	system	system	NOUN
admet-2455	381	44	:	:	PUNCT
admet-2455	381	45	turning	turn	VERB
admet-2455	381	46	peg	peg	NOUN
admet-2455	381	47	dilemma	dilemma	NOUN
admet-2455	381	48	into	into	ADP
admet-2455	381	49	prodrug	prodrug	NOUN
admet-2455	381	50	-	-	PUNCT
admet-2455	381	51	like	like	ADJ
admet-2455	381	52	feature	feature	NOUN
admet-2455	381	53	.	.	PUNCT
admet-2455	382	1	biomaterials	biomaterial	NOUN
admet-2455	382	2	116	116	NUM
admet-2455	382	3	(	(	PUNCT
admet-2455	382	4	2017	2017	NUM
admet-2455	382	5	)	)	PUNCT
admet-2455	382	6	57	57	NUM
admet-2455	382	7	-	-	SYM
admet-2455	382	8	68	68	NUM
admet-2455	382	9	.	.	PUNCT
admet-2455	383	1	https://doi.org/10.1016/j.biomaterials.2016.11.033	https://doi.org/10.1016/j.biomaterials.2016.11.033	NOUN
admet-2455	383	2	.	.	PUNCT
admet-2455	384	1	[	[	X
admet-2455	384	2	22	22	NUM
admet-2455	384	3	]	]	X
admet-2455	384	4	c.	c.	NOUN
admet-2455	384	5	you	you	PRON
admet-2455	384	6	,	,	PUNCT
admet-2455	384	7	y.	y.	PROPN
admet-2455	384	8	sun	sun	PROPN
admet-2455	384	9	,	,	PUNCT
admet-2455	384	10	s.	s.	PROPN
admet-2455	384	11	zhang	zhang	PROPN
admet-2455	384	12	,	,	PUNCT
admet-2455	384	13	g.	g.	PROPN
admet-2455	384	14	tang	tang	PROPN
admet-2455	384	15	,	,	PUNCT
admet-2455	384	16	n.	n.	PROPN
admet-2455	384	17	zhang	zhang	PROPN
admet-2455	384	18	,	,	PUNCT
admet-2455	384	19	c.	c.	PROPN
admet-2455	384	20	li	li	PROPN
admet-2455	384	21	,	,	PUNCT
admet-2455	384	22	x.	x.	PROPN
admet-2455	384	23	tian	tian	PROPN
admet-2455	384	24	,	,	PUNCT
admet-2455	384	25	s.	s.	PROPN
admet-2455	384	26	ma	ma	PROPN
admet-2455	384	27	,	,	PUNCT
admet-2455	384	28	y.	y.	PROPN
admet-2455	384	29	luo	luo	PROPN
admet-2455	384	30	,	,	PUNCT
admet-2455	384	31	w.	w.	PROPN
admet-2455	384	32	sun	sun	PROPN
admet-2455	384	33	,	,	PUNCT
admet-2455	384	34	f.	f.	PROPN
admet-2455	384	35	wang	wang	PROPN
admet-2455	384	36	,	,	PUNCT
admet-2455	384	37	x.	x.	PROPN
admet-2455	384	38	liu	liu	PROPN
admet-2455	384	39	,	,	PUNCT
admet-2455	384	40	y.	y.	PROPN
admet-2455	384	41	xiao	xiao	PROPN
admet-2455	384	42	,	,	PUNCT
admet-2455	384	43	y.	y.	PROPN
admet-2455	384	44	gong	gong	PROPN
admet-2455	384	45	,	,	PUNCT
admet-2455	384	46	j.	j.	PROPN
admet-2455	384	47	zhang	zhang	PROPN
admet-2455	384	48	,	,	PUNCT
admet-2455	384	49	c.	c.	PROPN
admet-2455	384	50	xie	xie	PROPN
admet-2455	384	51	.	.	PUNCT
admet-2455	385	1	trichosanthin	trichosanthin	PROPN
admet-2455	385	2	enhances	enhance	VERB
admet-2455	385	3	sensitivity	sensitivity	NOUN
admet-2455	385	4	of	of	ADP
admet-2455	385	5	non	non	ADJ
admet-2455	385	6	-	-	ADJ
admet-2455	385	7	small	small	ADJ
admet-2455	385	8	cell	cell	NOUN
admet-2455	385	9	lung	lung	NOUN
admet-2455	385	10	cancer	cancer	NOUN
admet-2455	385	11	(	(	PUNCT
admet-2455	385	12	nsclc	nsclc	NOUN
admet-2455	385	13	)	)	PUNCT
admet-2455	385	14	trail	trail	NOUN
admet-2455	385	15	-	-	PUNCT
admet-2455	385	16	resistance	resistance	NOUN
admet-2455	385	17	cells	cell	NOUN
admet-2455	385	18	.	.	PUNCT
admet-2455	386	1	int	int	NOUN
admet-2455	386	2	j	j	PROPN
admet-2455	386	3	biol	biol	PROPN
admet-2455	386	4	sci	sci	PROPN
admet-2455	386	5	14	14	NUM
admet-2455	386	6	(	(	PUNCT
admet-2455	386	7	2018	2018	NUM
admet-2455	386	8	)	)	PUNCT
admet-2455	386	9	217	217	NUM
admet-2455	386	10	-	-	SYM
admet-2455	386	11	227	227	NUM
admet-2455	386	12	.	.	PUNCT
admet-2455	386	13	https://doi.org/10.7150/ijbs.22811	https://doi.org/10.7150/ijbs.22811	PROPN
admet-2455	386	14	.	.	PUNCT
admet-2455	387	1	[	[	X
admet-2455	387	2	23	23	NUM
admet-2455	387	3	]	]	PUNCT
admet-2455	387	4	z.	z.	PROPN
admet-2455	387	5	zhu	zhu	PROPN
admet-2455	387	6	,	,	PUNCT
admet-2455	387	7	z.	z.	PROPN
admet-2455	387	8	ying	ying	PROPN
admet-2455	387	9	,	,	PUNCT
admet-2455	387	10	m.	m.	PROPN
admet-2455	387	11	zeng	zeng	PROPN
admet-2455	387	12	,	,	PUNCT
admet-2455	387	13	q.	q.	PROPN
admet-2455	387	14	zhang	zhang	PROPN
admet-2455	387	15	,	,	PUNCT
admet-2455	387	16	g.	g.	PROPN
admet-2455	387	17	liao	liao	PROPN
admet-2455	387	18	,	,	PUNCT
admet-2455	387	19	y.	y.	PROPN
admet-2455	387	20	liang	liang	PROPN
admet-2455	387	21	,	,	PUNCT
admet-2455	387	22	c.	c.	PROPN
admet-2455	387	23	li	li	PROPN
admet-2455	387	24	,	,	PUNCT
admet-2455	387	25	c.	c.	PROPN
admet-2455	387	26	zhang	zhang	PROPN
admet-2455	387	27	,	,	PUNCT
admet-2455	387	28	x.	x.	PROPN
admet-2455	387	29	wang	wang	PROPN
admet-2455	387	30	,	,	PUNCT
admet-2455	387	31	w.	w.	PROPN
admet-2455	387	32	jiang	jiang	PROPN
admet-2455	387	33	,	,	PUNCT
admet-2455	387	34	p.	p.	PROPN
admet-2455	387	35	luan	luan	PROPN
admet-2455	387	36	,	,	PUNCT
admet-2455	387	37	o.	o.	PROPN
admet-2455	387	38	sha	sha	PROPN
admet-2455	387	39	.	.	PUNCT
admet-2455	388	1	trichosanthin	trichosanthin	PROPN
admet-2455	388	2	cooperates	cooperate	VERB
admet-2455	388	3	with	with	ADP
admet-2455	388	4	granzyme	granzyme	NOUN
admet-2455	388	5	b	b	NOUN
admet-2455	388	6	to	to	PART
admet-2455	388	7	restrain	restrain	VERB
admet-2455	388	8	tumour	tumour	ADJ
admet-2455	388	9	formation	formation	NOUN
admet-2455	388	10	in	in	ADP
admet-2455	388	11	tongue	tongue	NOUN
admet-2455	388	12	squamous	squamous	ADJ
admet-2455	388	13	cell	cell	NOUN
admet-2455	388	14	carcinoma	carcinoma	NOUN
admet-2455	388	15	.	.	PUNCT
admet-2455	389	1	bmc	bmc	PROPN
admet-2455	389	2	complement	complement	PROPN
admet-2455	389	3	med	me	VERB
admet-2455	389	4	ther	ther	ADV
admet-2455	389	5	21	21	NUM
admet-2455	389	6	(	(	PUNCT
admet-2455	389	7	2021	2021	NUM
admet-2455	389	8	)	)	PUNCT
admet-2455	389	9	88	88	NUM
admet-2455	389	10	.	.	PUNCT
admet-2455	390	1	https://doi.org/10.1186/s12906-02103266-6	https://doi.org/10.1186/s12906-02103266-6	NOUN
admet-2455	390	2	.	.	PUNCT
admet-2455	391	1	[	[	X
admet-2455	391	2	24	24	NUM
admet-2455	391	3	]	]	PUNCT
admet-2455	391	4	k.	k.	PROPN
admet-2455	391	5	zhang	zhang	PROPN
admet-2455	391	6	,	,	PUNCT
admet-2455	391	7	j.	j.	PROPN
admet-2455	391	8	xu	xu	PROPN
admet-2455	391	9	,	,	PUNCT
admet-2455	391	10	x.	x.	PROPN
admet-2455	391	11	huang	huang	PROPN
admet-2455	391	12	,	,	PUNCT
admet-2455	391	13	l.	l.	PROPN
admet-2455	391	14	wu	wu	PROPN
admet-2455	391	15	,	,	PUNCT
admet-2455	391	16	c.	c.	PROPN
admet-2455	391	17	wen	wen	PROPN
admet-2455	391	18	,	,	PUNCT
admet-2455	391	19	y.	y.	PROPN
admet-2455	391	20	hu	hu	PROPN
admet-2455	391	21	,	,	PUNCT
admet-2455	391	22	y.	y.	PROPN
admet-2455	391	23	su	su	PROPN
admet-2455	391	24	,	,	PUNCT
admet-2455	391	25	y.	y.	PROPN
admet-2455	391	26	chen	chen	PROPN
admet-2455	391	27	,	,	PUNCT
admet-2455	391	28	z.	z.	PROPN
admet-2455	391	29	zhang	zhang	PROPN
admet-2455	391	30	.	.	PROPN
admet-2455	392	1	trichosanthin	trichosanthin	PROPN
admet-2455	392	2	downregulated	downregulate	VERB
admet-2455	392	3	p210bcr	p210bcr	PROPN
admet-2455	392	4	-	-	PUNCT
admet-2455	392	5	abl	abl	PROPN
admet-2455	392	6	and	and	CCONJ
admet-2455	392	7	enhanced	enhance	VERB
admet-2455	392	8	imatinib	imatinib	NOUN
admet-2455	392	9	-	-	PUNCT
admet-2455	392	10	induced	induce	VERB
admet-2455	392	11	growth	growth	NOUN
admet-2455	392	12	arrest	arrest	NOUN
admet-2455	392	13	in	in	ADP
admet-2455	392	14	chronic	chronic	ADJ
admet-2455	392	15	myelogenous	myelogenous	ADJ
admet-2455	392	16	leukemia	leukemia	NOUN
admet-2455	392	17	cell	cell	NOUN
admet-2455	392	18	line	line	NOUN
admet-2455	392	19	k562	k562	PROPN
admet-2455	392	20	.	.	PUNCT
admet-2455	393	1	cancer	cancer	NOUN
admet-2455	393	2	chemother	chemother	PROPN
admet-2455	393	3	pharmacol	pharmacol	PROPN
admet-2455	393	4	60	60	NUM
admet-2455	393	5	(	(	PUNCT
admet-2455	393	6	2007	2007	NUM
admet-2455	393	7	)	)	PUNCT
admet-2455	393	8	581	581	NUM
admet-2455	393	9	-	-	SYM
admet-2455	393	10	587	587	NUM
admet-2455	393	11	.	.	PUNCT
admet-2455	393	12	https://doi.org/10.1007/s00280-007-0457-0	https://doi.org/10.1007/s00280-007-0457-0	NUM
admet-2455	393	13	.	.	PUNCT
admet-2455	394	1	[	[	X
admet-2455	394	2	25	25	NUM
admet-2455	394	3	]	]	X
admet-2455	394	4	w.	w.	PROPN
admet-2455	394	5	li	li	PROPN
admet-2455	394	6	,	,	PUNCT
admet-2455	394	7	m.	m.	PROPN
admet-2455	394	8	zheng	zheng	PROPN
admet-2455	394	9	,	,	PUNCT
admet-2455	394	10	s.	s.	PROPN
admet-2455	394	11	wu	wu	PROPN
admet-2455	394	12	,	,	PUNCT
admet-2455	394	13	s.	s.	PROPN
admet-2455	394	14	gao	gao	PROPN
admet-2455	394	15	,	,	PUNCT
admet-2455	394	16	m.	m.	PROPN
admet-2455	394	17	yang	yang	PROPN
admet-2455	394	18	,	,	PUNCT
admet-2455	394	19	z.	z.	PROPN
admet-2455	394	20	li	li	PROPN
admet-2455	394	21	,	,	PUNCT
admet-2455	394	22	q.	q.	PROPN
admet-2455	394	23	min	min	PROPN
admet-2455	394	24	,	,	PUNCT
admet-2455	394	25	w.	w.	PROPN
admet-2455	394	26	sun	sun	PROPN
admet-2455	394	27	,	,	PUNCT
admet-2455	394	28	l.	l.	PROPN
admet-2455	394	29	chen	chen	PROPN
admet-2455	394	30	,	,	PUNCT
admet-2455	394	31	g.	g.	PROPN
admet-2455	394	32	xiang	xiang	PROPN
admet-2455	394	33	,	,	PUNCT
admet-2455	394	34	h.	h.	PROPN
admet-2455	394	35	li	li	PROPN
admet-2455	394	36	.	.	PROPN
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admet-2455	394	38	,	,	PUNCT
admet-2455	394	39	a	a	DET
admet-2455	394	40	dopadecarboxylase	dopadecarboxylase	NOUN
admet-2455	394	41	inhibitor	inhibitor	NOUN
admet-2455	394	42	,	,	PUNCT
admet-2455	394	43	suppresses	suppress	VERB
admet-2455	394	44	tumour	tumour	NOUN
admet-2455	394	45	growth	growth	NOUN
admet-2455	394	46	by	by	ADP
admet-2455	394	47	targeting	target	VERB
admet-2455	394	48	hexokinase	hexokinase	NOUN
admet-2455	394	49	2	2	NUM
admet-2455	394	50	.	.	PUNCT
admet-2455	395	1	j	j	PROPN
admet-2455	395	2	exp	exp	PROPN
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admet-2455	395	6	36	36	NUM
admet-2455	395	7	(	(	PUNCT
admet-2455	395	8	2017	2017	NUM
admet-2455	395	9	)	)	PUNCT
admet-2455	395	10	58	58	NUM
admet-2455	395	11	.	.	PUNCT
admet-2455	396	1	https://doi.org/10.1186/s13046-017-0530-4	https://doi.org/10.1186/s13046-017-0530-4	PROPN
admet-2455	396	2	.	.	PUNCT
admet-2455	397	1	[	[	X
admet-2455	397	2	26	26	NUM
admet-2455	397	3	]	]	PUNCT
admet-2455	397	4	e.g.	e.g.	ADV
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admet-2455	397	6	v.	v.	PROPN
admet-2455	397	7	bijnsdorp	bijnsdorp	PROPN
admet-2455	397	8	,	,	PUNCT
admet-2455	397	9	godefridus	godefridus	PROPN
admet-2455	397	10	j.	j.	PROPN
admet-2455	397	11	peters	peters	PROPN
admet-2455	397	12	,	,	PUNCT
admet-2455	397	13	analysis	analysis	NOUN
admet-2455	397	14	of	of	ADP
admet-2455	397	15	drug	drug	NOUN
admet-2455	397	16	interactions	interaction	NOUN
admet-2455	397	17	,	,	PUNCT
admet-2455	397	18	in	in	ADP
admet-2455	397	19	cancer	cancer	NOUN
admet-2455	397	20	cell	cell	NOUN
admet-2455	397	21	culture	culture	NOUN
admet-2455	397	22	,	,	PUNCT
admet-2455	397	23	i.a	i.a	PROPN
admet-2455	397	24	.	.	PROPN
admet-2455	397	25	cree	cree	PROPN
admet-2455	397	26	(	(	PUNCT
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admet-2455	397	28	.	.	PUNCT
admet-2455	397	29	)	)	PUNCT
admet-2455	397	30	,	,	PUNCT
admet-2455	397	31	humana	humana	PROPN
admet-2455	397	32	press	press	PROPN
admet-2455	397	33	,	,	PUNCT
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admet-2455	397	36	,	,	PUNCT
admet-2455	397	37	2011	2011	NUM
admet-2455	397	38	.	.	PUNCT
admet-2455	398	1	https://doi.org/10.1007/978-1-61779-080-5	https://doi.org/10.1007/978-1-61779-080-5	PROPN
admet-2455	399	1	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	X
admet-2455	399	2	https://doi.org/10.1038/s41573-021-00339-6	https://doi.org/10.1038/s41573-021-00339-6	NUM
admet-2455	399	3	https://doi.org/10.1111/bph.14816	https://doi.org/10.1111/bph.14816	PROPN
admet-2455	399	4	https://doi.org/10.1007/s13659-020-00293-7	https://doi.org/10.1007/s13659-020-00293-7	NUM
admet-2455	399	5	https://doi.org/10.1016/0024-3205(94)00727-6	https://doi.org/10.1016/0024-3205(94)00727-6	PROPN
admet-2455	399	6	https://doi.org/10.1016/0024-3205(94)00727-6	https://doi.org/10.1016/0024-3205(94)00727-6	PROPN
admet-2455	399	7	https://doi.org/10.1007/s00280-013-2096-y	https://doi.org/10.1007/s00280-013-2096-y	PROPN
admet-2455	399	8	https://doi.org/10.3390/toxins10080335	https://doi.org/10.3390/toxins10080335	NOUN
admet-2455	399	9	https://doi.org/10.21037/jtd-22-282	https://doi.org/10.21037/jtd-22-282	PROPN
admet-2455	400	1	https://doi.org/10.1371/journal.pone.0041592	https://doi.org/10.1371/journal.pone.0041592	PROPN
admet-2455	400	2	https://doi.org/10.3390/ijms24021416	https://doi.org/10.3390/ijms24021416	PROPN
admet-2455	401	1	https://doi.org/10.1016/j.cellimm.2005.04.015	https://doi.org/10.1016/j.cellimm.2005.04.015	NUM
admet-2455	401	2	https://doi.org/10.3390/toxins14030178	https://doi.org/10.3390/toxins14030178	PROPN
admet-2455	402	1	https://doi.org/10.1016/j.biomaterials.2016.11.033	https://doi.org/10.1016/j.biomaterials.2016.11.033	NUM
admet-2455	402	2	https://doi.org/10.7150/ijbs.22811	https://doi.org/10.7150/ijbs.22811	NOUN
admet-2455	402	3	https://doi.org/10.1186/s12906-021-03266-6	https://doi.org/10.1186/s12906-021-03266-6	PROPN
admet-2455	402	4	https://doi.org/10.1186/s12906-021-03266-6	https://doi.org/10.1186/s12906-021-03266-6	NUM
admet-2455	402	5	https://doi.org/10.1007/s00280-007-0457-0	https://doi.org/10.1007/s00280-007-0457-0	NUM
admet-2455	403	1	https://doi.org/10.1186/s13046-017-0530-4	https://doi.org/10.1186/s13046-017-0530-4	NUM
admet-2455	403	2	https://doi.org/10.1007/978-1-61779-080-5	https://doi.org/10.1007/978-1-61779-080-5	PROPN
admet-2455	403	3	y.	y.	PROPN
admet-2455	403	4	zhou	zhou	PROPN
admet-2455	403	5	et	et	PROPN
admet-2455	403	6	al	al	PROPN
admet-2455	403	7	.	.	PROPN
admet-2455	403	8	admet	admet	PROPN
admet-2455	403	9	&	&	CCONJ
admet-2455	403	10	dmpk	dmpk	PROPN
admet-2455	403	11	12(6	12(6	NUM
admet-2455	403	12	)	)	PUNCT
admet-2455	403	13	(	(	PUNCT
admet-2455	403	14	2024	2024	NUM
admet-2455	403	15	)	)	PUNCT
admet-2455	403	16	821	821	NUM
admet-2455	403	17	-	-	SYM
admet-2455	403	18	841	841	NUM
admet-2455	403	19	840	840	NUM
admet-2455	404	1	[	[	SYM
admet-2455	404	2	27	27	NUM
admet-2455	404	3	]	]	X
admet-2455	404	4	t.c	t.c	PROPN
admet-2455	404	5	.	.	PROPN
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admet-2455	404	9	combination	combination	NOUN
admet-2455	404	10	studies	study	NOUN
admet-2455	404	11	and	and	CCONJ
admet-2455	404	12	their	their	PRON
admet-2455	404	13	synergy	synergy	NOUN
admet-2455	404	14	quantification	quantification	NOUN
admet-2455	404	15	using	use	VERB
admet-2455	404	16	the	the	DET
admet-2455	404	17	chou	chou	NOUN
admet-2455	404	18	-	-	PUNCT
admet-2455	404	19	talalay	talalay	NOUN
admet-2455	404	20	method	method	NOUN
admet-2455	404	21	.	.	PUNCT
admet-2455	405	1	cancer	cancer	NOUN
admet-2455	405	2	res	re	NOUN
admet-2455	405	3	70	70	NUM
admet-2455	405	4	(	(	PUNCT
admet-2455	405	5	2010	2010	NUM
admet-2455	405	6	)	)	PUNCT
admet-2455	405	7	440	440	NUM
admet-2455	405	8	-	-	SYM
admet-2455	405	9	446	446	NUM
admet-2455	405	10	.	.	PUNCT
admet-2455	406	1	https://doi.org/10.1158/0008-5472.can-09-1947	https://doi.org/10.1158/0008-5472.can-09-1947	X
admet-2455	406	2	.	.	PUNCT
admet-2455	407	1	[	[	X
admet-2455	407	2	28	28	NUM
admet-2455	407	3	]	]	X
admet-2455	407	4	b.	b.	PROPN
admet-2455	407	5	el	el	PROPN
admet-2455	407	6	hassouni	hassouni	PROPN
admet-2455	407	7	,	,	PUNCT
admet-2455	407	8	g.	g.	PROPN
admet-2455	407	9	mantini	mantini	PROPN
admet-2455	407	10	,	,	PUNCT
admet-2455	407	11	g.	g.	PROPN
admet-2455	407	12	li	li	PROPN
admet-2455	407	13	petri	petri	PROPN
admet-2455	407	14	,	,	PUNCT
admet-2455	407	15	m.	m.	NOUN
admet-2455	407	16	capula	capula	PROPN
admet-2455	407	17	,	,	PUNCT
admet-2455	407	18	l.	l.	PROPN
admet-2455	407	19	boyd	boyd	PROPN
admet-2455	407	20	,	,	PUNCT
admet-2455	407	21	h.n.w	h.n.w	PROPN
admet-2455	407	22	.	.	PUNCT
admet-2455	407	23	weinstein	weinstein	PROPN
admet-2455	407	24	,	,	PUNCT
admet-2455	407	25	a.	a.	PROPN
admet-2455	407	26	valles	valles	PROPN
admet-2455	407	27	-	-	PUNCT
admet-2455	407	28	marti	marti	PROPN
admet-2455	407	29	,	,	PUNCT
admet-2455	407	30	m.c.m	m.c.m	X
admet-2455	407	31	.	.	PUNCT
admet-2455	407	32	kouwenhoven	kouwenhoven	PROPN
admet-2455	407	33	,	,	PUNCT
admet-2455	407	34	e.	e.	PROPN
admet-2455	407	35	giovannetti	giovannetti	PROPN
admet-2455	407	36	,	,	PUNCT
admet-2455	407	37	b.a	b.a	PROPN
admet-2455	407	38	.	.	PROPN
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admet-2455	407	40	,	,	PUNCT
admet-2455	407	41	g.j	g.j	PROPN
admet-2455	407	42	.	.	PROPN
admet-2455	407	43	peters	peters	PROPN
admet-2455	407	44	,	,	PUNCT
admet-2455	407	45	e.p	e.p	PROPN
admet-2455	407	46	.	.	PROPN
admet-2455	407	47	group	group	NOUN
admet-2455	407	48	.	.	PUNCT
admet-2455	408	1	to	to	PART
admet-2455	408	2	combine	combine	VERB
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admet-2455	408	5	combine	combine	VERB
admet-2455	408	6	:	:	PUNCT
admet-2455	408	7	drug	drug	NOUN
admet-2455	408	8	interactions	interaction	NOUN
admet-2455	408	9	and	and	CCONJ
admet-2455	408	10	tools	tool	NOUN
admet-2455	408	11	for	for	ADP
admet-2455	408	12	their	their	PRON
admet-2455	408	13	analysis	analysis	NOUN
admet-2455	408	14	.	.	PUNCT
admet-2455	409	1	reflections	reflection	NOUN
admet-2455	409	2	from	from	ADP
admet-2455	409	3	the	the	DET
admet-2455	409	4	eortc	eortc	ADJ
admet-2455	409	5	-	-	PUNCT
admet-2455	409	6	pamm	pamm	NOUN
admet-2455	409	7	course	course	NOUN
admet-2455	409	8	on	on	ADP
admet-2455	409	9	preclinical	preclinical	ADJ
admet-2455	409	10	and	and	CCONJ
admet-2455	409	11	early	early	ADJ
admet-2455	409	12	-	-	PUNCT
admet-2455	409	13	phase	phase	NOUN
admet-2455	409	14	clinical	clinical	ADJ
admet-2455	409	15	pharmacology	pharmacology	NOUN
admet-2455	409	16	.	.	PUNCT
admet-2455	410	1	anticancer	anticancer	NOUN
admet-2455	410	2	res	re	VERB
admet-2455	410	3	39	39	NUM
admet-2455	410	4	(	(	PUNCT
admet-2455	410	5	2019	2019	NUM
admet-2455	410	6	)	)	PUNCT
admet-2455	410	7	3303	3303	NUM
admet-2455	410	8	-	-	SYM
admet-2455	410	9	3309	3309	NUM
admet-2455	410	10	.	.	PUNCT
admet-2455	411	1	https://doi.org/10.21873/anticanres.13472	https://doi.org/10.21873/anticanres.13472	X
admet-2455	411	2	.	.	PUNCT
admet-2455	412	1	[	[	X
admet-2455	412	2	29	29	NUM
admet-2455	412	3	]	]	PUNCT
admet-2455	412	4	a.	a.	NOUN
admet-2455	412	5	nabbi	nabbi	PROPN
admet-2455	412	6	,	,	PUNCT
admet-2455	412	7	k.	k.	PROPN
admet-2455	412	8	riabowol	riabowol	PROPN
admet-2455	412	9	.	.	PUNCT
admet-2455	413	1	rapid	rapid	ADJ
admet-2455	413	2	isolation	isolation	NOUN
admet-2455	413	3	of	of	ADP
admet-2455	413	4	nuclei	nucleus	NOUN
admet-2455	413	5	from	from	ADP
admet-2455	413	6	cells	cell	NOUN
admet-2455	413	7	in	in	ADP
admet-2455	413	8	vitro	vitro	X
admet-2455	413	9	.	.	PUNCT
admet-2455	414	1	cold	cold	ADJ
admet-2455	414	2	spring	spring	NOUN
admet-2455	414	3	harb	harb	PROPN
admet-2455	414	4	protoc	protoc	VERB
admet-2455	414	5	2015	2015	NUM
admet-2455	414	6	(	(	PUNCT
admet-2455	414	7	2015	2015	NUM
admet-2455	414	8	)	)	PUNCT
admet-2455	414	9	769	769	NUM
admet-2455	414	10	-	-	SYM
admet-2455	414	11	772	772	NUM
admet-2455	414	12	.	.	PUNCT
admet-2455	415	1	https://doi.org/10.1101/pdb.prot083733	https://doi.org/10.1101/pdb.prot083733	ADJ
admet-2455	415	2	.	.	PUNCT
admet-2455	416	1	[	[	X
admet-2455	416	2	30	30	NUM
admet-2455	416	3	]	]	X
admet-2455	416	4	c.	c.	PROPN
admet-2455	416	5	liu	liu	PROPN
admet-2455	416	6	,	,	PUNCT
admet-2455	416	7	x.	x.	PROPN
admet-2455	416	8	wang	wang	PROPN
admet-2455	416	9	,	,	PUNCT
admet-2455	416	10	y.	y.	PROPN
admet-2455	416	11	zhang	zhang	PROPN
admet-2455	416	12	.	.	PUNCT
admet-2455	417	1	the	the	DET
admet-2455	417	2	roles	role	NOUN
admet-2455	417	3	of	of	ADP
admet-2455	417	4	hk2	hk2	PROPN
admet-2455	417	5	on	on	ADP
admet-2455	417	6	tumour	tumour	ADJ
admet-2455	417	7	igenesis	igenesis	NOUN
admet-2455	417	8	of	of	ADP
admet-2455	417	9	cervical	cervical	ADJ
admet-2455	417	10	cancer	cancer	NOUN
admet-2455	417	11	.	.	PUNCT
admet-2455	418	1	technol	technol	NOUN
admet-2455	418	2	cancer	cancer	NOUN
admet-2455	418	3	res	re	NOUN
admet-2455	418	4	treat	treat	VERB
admet-2455	418	5	18	18	NUM
admet-2455	418	6	(	(	PUNCT
admet-2455	418	7	2019	2019	NUM
admet-2455	418	8	)	)	PUNCT
admet-2455	418	9	1533033819871306	1533033819871306	NUM
admet-2455	418	10	.	.	PUNCT
admet-2455	419	1	https://doi.org/10.1177/1533033819871306	https://doi.org/10.1177/1533033819871306	ADJ
admet-2455	419	2	.	.	PUNCT
admet-2455	420	1	[	[	X
admet-2455	420	2	31	31	NUM
admet-2455	420	3	]	]	PUNCT
admet-2455	420	4	c.	c.	PROPN
admet-2455	420	5	liu	liu	PROPN
admet-2455	420	6	,	,	PUNCT
admet-2455	420	7	h.	h.	PROPN
admet-2455	420	8	li	li	PROPN
admet-2455	420	9	,	,	PUNCT
admet-2455	420	10	h.	h.	PROPN
admet-2455	420	11	huang	huang	PROPN
admet-2455	420	12	,	,	PUNCT
admet-2455	420	13	p.	p.	PROPN
admet-2455	420	14	zheng	zheng	PROPN
admet-2455	420	15	,	,	PUNCT
admet-2455	420	16	z.	z.	PROPN
admet-2455	420	17	li	li	PROPN
admet-2455	420	18	.	.	PUNCT
admet-2455	421	1	the	the	DET
admet-2455	421	2	correlation	correlation	NOUN
admet-2455	421	3	of	of	ADP
admet-2455	421	4	hk2	hk2	NOUN
admet-2455	421	5	gene	gene	NOUN
admet-2455	421	6	expression	expression	NOUN
admet-2455	421	7	with	with	ADP
admet-2455	421	8	the	the	DET
admet-2455	421	9	occurrence	occurrence	NOUN
admet-2455	421	10	,	,	PUNCT
admet-2455	421	11	immune	immune	ADJ
admet-2455	421	12	cell	cell	NOUN
admet-2455	421	13	infiltration	infiltration	NOUN
admet-2455	421	14	,	,	PUNCT
admet-2455	421	15	and	and	CCONJ
admet-2455	421	16	prognosis	prognosis	NOUN
admet-2455	421	17	of	of	ADP
admet-2455	421	18	renal	renal	ADJ
admet-2455	421	19	cell	cell	NOUN
admet-2455	421	20	carcinoma	carcinoma	NOUN
admet-2455	421	21	.	.	PUNCT
admet-2455	422	1	dis	dis	PROPN
admet-2455	422	2	markers	marker	VERB
admet-2455	422	3	2022	2022	NUM
admet-2455	422	4	(	(	PUNCT
admet-2455	422	5	2022	2022	NUM
admet-2455	422	6	)	)	PUNCT
admet-2455	422	7	1452861	1452861	NUM
admet-2455	422	8	.	.	PUNCT
admet-2455	423	1	https://doi.org/10.1155/2022/1452861	https://doi.org/10.1155/2022/1452861	PROPN
admet-2455	423	2	.	.	PUNCT
admet-2455	424	1	[	[	X
admet-2455	424	2	32	32	NUM
admet-2455	424	3	]	]	X
admet-2455	424	4	k.c	k.c	PROPN
admet-2455	424	5	.	.	PROPN
admet-2455	424	6	patra	patra	PROPN
admet-2455	424	7	,	,	PUNCT
admet-2455	424	8	q.	q.	PROPN
admet-2455	424	9	wang	wang	PROPN
admet-2455	424	10	,	,	PUNCT
admet-2455	424	11	p.t	p.t	PROPN
admet-2455	424	12	.	.	PROPN
admet-2455	424	13	bhaskar	bhaskar	PROPN
admet-2455	424	14	,	,	PUNCT
admet-2455	424	15	l.	l.	PROPN
admet-2455	424	16	miller	miller	PROPN
admet-2455	424	17	,	,	PUNCT
admet-2455	424	18	z.	z.	PROPN
admet-2455	424	19	wang	wang	PROPN
admet-2455	424	20	,	,	PUNCT
admet-2455	424	21	w.	w.	PROPN
admet-2455	424	22	wheaton	wheaton	PROPN
admet-2455	424	23	,	,	PUNCT
admet-2455	424	24	n.	n.	PROPN
admet-2455	424	25	chandel	chandel	PROPN
admet-2455	424	26	,	,	PUNCT
admet-2455	424	27	m.	m.	NOUN
admet-2455	424	28	laakso	laakso	PROPN
admet-2455	424	29	,	,	PUNCT
admet-2455	424	30	w.j	w.j	PROPN
admet-2455	424	31	.	.	PROPN
admet-2455	424	32	muller	muller	PROPN
admet-2455	424	33	,	,	PUNCT
admet-2455	424	34	e.l	e.l	PROPN
admet-2455	424	35	.	.	PROPN
admet-2455	424	36	allen	allen	PROPN
admet-2455	424	37	,	,	PUNCT
admet-2455	424	38	a.k	a.k	PROPN
admet-2455	424	39	.	.	PROPN
admet-2455	424	40	jha	jha	PROPN
admet-2455	424	41	,	,	PUNCT
admet-2455	424	42	g.a	g.a	PROPN
admet-2455	424	43	.	.	PROPN
admet-2455	424	44	smolen	smolen	PROPN
admet-2455	424	45	,	,	PUNCT
admet-2455	424	46	m.f	m.f	PROPN
admet-2455	424	47	.	.	PROPN
admet-2455	424	48	clasquin	clasquin	PROPN
admet-2455	424	49	,	,	PUNCT
admet-2455	424	50	b.	b.	PROPN
admet-2455	424	51	robey	robey	PROPN
admet-2455	424	52	,	,	PUNCT
admet-2455	424	53	n.	n.	PROPN
admet-2455	424	54	hay	hay	PROPN
admet-2455	424	55	.	.	PUNCT
admet-2455	425	1	hexokinase	hexokinase	PROPN
admet-2455	425	2	2	2	NUM
admet-2455	425	3	is	be	AUX
admet-2455	425	4	required	require	VERB
admet-2455	425	5	for	for	ADP
admet-2455	425	6	tumour	tumour	NOUN
admet-2455	425	7	initiation	initiation	NOUN
admet-2455	425	8	and	and	CCONJ
admet-2455	425	9	maintenance	maintenance	NOUN
admet-2455	425	10	and	and	CCONJ
admet-2455	425	11	its	its	PRON
admet-2455	425	12	systemic	systemic	ADJ
admet-2455	425	13	deletion	deletion	NOUN
admet-2455	425	14	is	be	AUX
admet-2455	425	15	therapeutic	therapeutic	ADJ
admet-2455	425	16	in	in	ADP
admet-2455	425	17	mouse	mouse	NOUN
admet-2455	425	18	models	model	NOUN
admet-2455	425	19	of	of	ADP
admet-2455	425	20	cancer	cancer	NOUN
admet-2455	425	21	.	.	PUNCT
admet-2455	426	1	cancer	cancer	NOUN
admet-2455	426	2	cell	cell	NOUN
admet-2455	426	3	24	24	NUM
admet-2455	426	4	(	(	PUNCT
admet-2455	426	5	2013	2013	NUM
admet-2455	426	6	)	)	PUNCT
admet-2455	426	7	213	213	NUM
admet-2455	426	8	-	-	SYM
admet-2455	426	9	228	228	NUM
admet-2455	426	10	.	.	PUNCT
admet-2455	427	1	https://doi.org/10.1016/j.ccr.2013.06.014	https://doi.org/10.1016/j.ccr.2013.06.014	AUX
admet-2455	427	2	.	.	PUNCT
admet-2455	428	1	[	[	X
admet-2455	428	2	33	33	NUM
admet-2455	428	3	]	]	X
admet-2455	428	4	s.n	s.n	PROPN
admet-2455	428	5	.	.	PROPN
admet-2455	428	6	garcia	garcia	PROPN
admet-2455	428	7	,	,	PUNCT
admet-2455	428	8	r.c	r.c	PROPN
admet-2455	428	9	.	.	PROPN
admet-2455	428	10	guedes	guedes	PROPN
admet-2455	428	11	,	,	PUNCT
admet-2455	428	12	m.m	m.m	PROPN
admet-2455	428	13	.	.	PROPN
admet-2455	428	14	marques	marques	PROPN
admet-2455	428	15	.	.	PUNCT
admet-2455	428	16	unlocking	unlock	VERB
admet-2455	428	17	the	the	DET
admet-2455	428	18	potential	potential	NOUN
admet-2455	428	19	of	of	ADP
admet-2455	428	20	hk2	hk2	PROPN
admet-2455	428	21	in	in	ADP
admet-2455	428	22	cancer	cancer	NOUN
admet-2455	428	23	metabolism	metabolism	NOUN
admet-2455	428	24	and	and	CCONJ
admet-2455	428	25	therapeutics	therapeutic	NOUN
admet-2455	428	26	.	.	PUNCT
admet-2455	429	1	curr	curr	PROPN
admet-2455	429	2	med	med	PROPN
admet-2455	429	3	chem	chem	NOUN
admet-2455	429	4	26	26	NUM
admet-2455	429	5	(	(	PUNCT
admet-2455	429	6	2019	2019	NUM
admet-2455	429	7	)	)	PUNCT
admet-2455	429	8	7285	7285	NUM
admet-2455	429	9	-	-	SYM
admet-2455	429	10	7322	7322	NUM
admet-2455	429	11	.	.	PUNCT
admet-2455	430	1	https://doi.org/10.2174/0929867326666181213092652	https://doi.org/10.2174/0929867326666181213092652	PROPN
admet-2455	430	2	.	.	PUNCT
admet-2455	431	1	[	[	X
admet-2455	431	2	34	34	NUM
admet-2455	431	3	]	]	X
admet-2455	431	4	c.r	c.r	PROPN
admet-2455	431	5	.	.	PROPN
admet-2455	431	6	reczek	reczek	PROPN
admet-2455	431	7	,	,	PUNCT
admet-2455	431	8	n.s	n.s	PROPN
admet-2455	431	9	.	.	PROPN
admet-2455	431	10	chandel	chandel	PROPN
admet-2455	431	11	.	.	PUNCT
admet-2455	432	1	the	the	DET
admet-2455	432	2	two	two	NUM
admet-2455	432	3	faces	face	NOUN
admet-2455	432	4	of	of	ADP
admet-2455	432	5	reactive	reactive	ADJ
admet-2455	432	6	oxygen	oxygen	NOUN
admet-2455	432	7	species	specie	NOUN
admet-2455	432	8	in	in	ADP
admet-2455	432	9	cancer	cancer	NOUN
admet-2455	432	10	.	.	PUNCT
admet-2455	433	1	annual	annual	ADJ
admet-2455	433	2	review	review	NOUN
admet-2455	433	3	of	of	ADP
admet-2455	433	4	cancer	cancer	NOUN
admet-2455	433	5	biology	biology	NOUN
admet-2455	433	6	1	1	NUM
admet-2455	433	7	(	(	PUNCT
admet-2455	433	8	2017	2017	NUM
admet-2455	433	9	)	)	PUNCT
admet-2455	433	10	79	79	NUM
admet-2455	433	11	-	-	SYM
admet-2455	433	12	98	98	NUM
admet-2455	433	13	.	.	PUNCT
admet-2455	434	1	https://doi.org/10.1146/annurev-cancerbio-041916-065808	https://doi.org/10.1146/annurev-cancerbio-041916-065808	NOUN
admet-2455	434	2	.	.	PUNCT
admet-2455	435	1	[	[	X
admet-2455	435	2	35	35	NUM
admet-2455	435	3	]	]	X
admet-2455	435	4	s.	s.	PROPN
admet-2455	435	5	rodic	rodic	PROPN
admet-2455	435	6	,	,	PUNCT
admet-2455	435	7	m.d	m.d	PROPN
admet-2455	435	8	.	.	PROPN
admet-2455	435	9	vincent	vincent	PROPN
admet-2455	435	10	.	.	PUNCT
admet-2455	436	1	reactive	reactive	ADJ
admet-2455	436	2	oxygen	oxygen	NOUN
admet-2455	436	3	species	specie	NOUN
admet-2455	436	4	(	(	PUNCT
admet-2455	436	5	ros	ros	PROPN
admet-2455	436	6	)	)	PUNCT
admet-2455	436	7	are	be	AUX
admet-2455	436	8	a	a	DET
admet-2455	436	9	key	key	ADJ
admet-2455	436	10	determinant	determinant	NOUN
admet-2455	436	11	of	of	ADP
admet-2455	436	12	cancer	cancer	NOUN
admet-2455	436	13	's	's	PART
admet-2455	436	14	metabolic	metabolic	NOUN
admet-2455	436	15	phenotype	phenotype	NOUN
admet-2455	436	16	.	.	PUNCT
admet-2455	437	1	int	int	PROPN
admet-2455	437	2	j	j	PROPN
admet-2455	437	3	cancer	cancer	NOUN
admet-2455	437	4	142	142	NUM
admet-2455	437	5	(	(	PUNCT
admet-2455	437	6	2018	2018	NUM
admet-2455	437	7	)	)	PUNCT
admet-2455	437	8	440	440	NUM
admet-2455	437	9	-	-	SYM
admet-2455	437	10	448	448	NUM
admet-2455	437	11	.	.	PUNCT
admet-2455	437	12	https://doi.org/10.1002/ijc.31069	https://doi.org/10.1002/ijc.31069	NOUN
admet-2455	437	13	.	.	PUNCT
admet-2455	438	1	[	[	X
admet-2455	438	2	36	36	NUM
admet-2455	438	3	]	]	X
admet-2455	438	4	m.	m.	PROPN
admet-2455	438	5	lee	lee	PROPN
admet-2455	438	6	,	,	PUNCT
admet-2455	438	7	j.h	j.h	PROPN
admet-2455	438	8	.	.	PROPN
admet-2455	438	9	yoon	yoon	PROPN
admet-2455	438	10	.	.	PUNCT
admet-2455	439	1	metabolic	metabolic	NOUN
admet-2455	439	2	interplay	interplay	NOUN
admet-2455	439	3	between	between	ADP
admet-2455	439	4	glycolysis	glycolysis	NOUN
admet-2455	439	5	and	and	CCONJ
admet-2455	439	6	mitochondrial	mitochondrial	ADJ
admet-2455	439	7	oxidation	oxidation	NOUN
admet-2455	439	8	:	:	PUNCT
admet-2455	439	9	the	the	DET
admet-2455	439	10	reverse	reverse	ADJ
admet-2455	439	11	warburg	warburg	NOUN
admet-2455	439	12	effect	effect	NOUN
admet-2455	439	13	and	and	CCONJ
admet-2455	439	14	its	its	PRON
admet-2455	439	15	therapeutic	therapeutic	ADJ
admet-2455	439	16	implication	implication	NOUN
admet-2455	439	17	.	.	PUNCT
admet-2455	440	1	world	world	PROPN
admet-2455	440	2	j	j	PROPN
admet-2455	440	3	biol	biol	PROPN
admet-2455	440	4	chem	chem	NOUN
admet-2455	440	5	6	6	NUM
admet-2455	440	6	(	(	PUNCT
admet-2455	440	7	2015	2015	NUM
admet-2455	440	8	)	)	PUNCT
admet-2455	440	9	148	148	NUM
admet-2455	440	10	-	-	SYM
admet-2455	440	11	161	161	NUM
admet-2455	440	12	.	.	PUNCT
admet-2455	441	1	https://doi.org/10.4331/wjbc.v6.i3.148	https://doi.org/10.4331/wjbc.v6.i3.148	NOUN
admet-2455	441	2	.	.	PUNCT
admet-2455	442	1	[	[	X
admet-2455	442	2	37	37	NUM
admet-2455	442	3	]	]	X
admet-2455	442	4	c.	c.	PROPN
admet-2455	442	5	zhu	zhu	PROPN
admet-2455	442	6	,	,	PUNCT
admet-2455	442	7	c.	c.	PROPN
admet-2455	442	8	zhang	zhang	PROPN
admet-2455	442	9	,	,	PUNCT
admet-2455	442	10	x.	x.	PROPN
admet-2455	442	11	cui	cui	PROPN
admet-2455	442	12	,	,	PUNCT
admet-2455	442	13	j.	j.	PROPN
admet-2455	442	14	wu	wu	PROPN
admet-2455	442	15	,	,	PUNCT
admet-2455	442	16	z.	z.	PROPN
admet-2455	442	17	cui	cui	PROPN
admet-2455	442	18	,	,	PUNCT
admet-2455	442	19	x.	x.	PROPN
admet-2455	442	20	shen	shen	PROPN
admet-2455	442	21	.	.	PUNCT
admet-2455	443	1	trichosanthin	trichosanthin	PROPN
admet-2455	443	2	inhibits	inhibit	VERB
admet-2455	443	3	cervical	cervical	ADJ
admet-2455	443	4	cancer	cancer	NOUN
admet-2455	443	5	by	by	ADP
admet-2455	443	6	regulating	regulate	VERB
admet-2455	443	7	oxidative	oxidative	ADJ
admet-2455	443	8	stress	stress	NOUN
admet-2455	443	9	-	-	PUNCT
admet-2455	443	10	induced	induce	VERB
admet-2455	443	11	apoptosis	apoptosis	NOUN
admet-2455	443	12	.	.	PUNCT
admet-2455	444	1	bioengineered	bioengineere	VERB
admet-2455	444	2	12	12	NUM
admet-2455	444	3	(	(	PUNCT
admet-2455	444	4	2021	2021	NUM
admet-2455	444	5	)	)	PUNCT
admet-2455	444	6	2779	2779	NUM
admet-2455	444	7	-	-	SYM
admet-2455	444	8	2790	2790	NUM
admet-2455	444	9	.	.	PUNCT
admet-2455	445	1	https://doi.org/10.1080/21655979.2021.1930335	https://doi.org/10.1080/21655979.2021.1930335	NOUN
admet-2455	445	2	.	.	PUNCT
admet-2455	446	1	[	[	X
admet-2455	446	2	38	38	NUM
admet-2455	446	3	]	]	PUNCT
admet-2455	446	4	b.	b.	PROPN
admet-2455	446	5	wei	wei	PROPN
admet-2455	446	6	,	,	PUNCT
admet-2455	446	7	q.	q.	PROPN
admet-2455	446	8	huang	huang	PROPN
admet-2455	446	9	,	,	PUNCT
admet-2455	446	10	s.	s.	PROPN
admet-2455	446	11	huang	huang	PROPN
admet-2455	446	12	,	,	PUNCT
admet-2455	446	13	w.	w.	PROPN
admet-2455	446	14	mai	mai	PROPN
admet-2455	446	15	,	,	PUNCT
admet-2455	446	16	x.	x.	PROPN
admet-2455	446	17	zhong	zhong	PROPN
admet-2455	446	18	.	.	PROPN
admet-2455	446	19	trichosanthin	trichosanthin	PROPN
admet-2455	446	20	-	-	PUNCT
admet-2455	446	21	induced	induce	VERB
admet-2455	446	22	autophagy	autophagy	NOUN
admet-2455	446	23	in	in	ADP
admet-2455	446	24	gastric	gastric	ADJ
admet-2455	446	25	cancer	cancer	NOUN
admet-2455	446	26	cell	cell	NOUN
admet-2455	446	27	mkn-45	mkn-45	CCONJ
admet-2455	446	28	is	be	AUX
admet-2455	446	29	dependent	dependent	ADJ
admet-2455	446	30	on	on	ADP
admet-2455	446	31	reactive	reactive	ADJ
admet-2455	446	32	oxygen	oxygen	NOUN
admet-2455	446	33	species	specie	NOUN
admet-2455	446	34	(	(	PUNCT
admet-2455	446	35	ros	ros	PROPN
admet-2455	446	36	)	)	PUNCT
admet-2455	446	37	and	and	CCONJ
admet-2455	446	38	nf	nf	ADJ
admet-2455	446	39	-	-	PUNCT
admet-2455	446	40	kappab	kappab	NOUN
admet-2455	446	41	/	/	SYM
admet-2455	446	42	p53	p53	NOUN
admet-2455	446	43	pathway	pathway	NOUN
admet-2455	446	44	.	.	PUNCT
admet-2455	447	1	j	j	PROPN
admet-2455	447	2	pharmacol	pharmacol	PROPN
admet-2455	447	3	sci	sci	PROPN
admet-2455	447	4	131	131	NUM
admet-2455	447	5	(	(	PUNCT
admet-2455	447	6	2016	2016	NUM
admet-2455	447	7	)	)	PUNCT
admet-2455	447	8	77	77	NUM
admet-2455	447	9	-	-	SYM
admet-2455	447	10	83	83	NUM
admet-2455	447	11	.	.	PUNCT
admet-2455	448	1	https://doi.org/10.1016/j.jphs.2016.03.001	https://doi.org/10.1016/j.jphs.2016.03.001	VERB
admet-2455	448	2	.	.	PUNCT
admet-2455	449	1	[	[	X
admet-2455	449	2	39	39	NUM
admet-2455	449	3	]	]	PUNCT
admet-2455	449	4	l.	l.	PROPN
admet-2455	449	5	dong	dong	PROPN
admet-2455	449	6	,	,	PUNCT
admet-2455	449	7	j.	j.	PROPN
admet-2455	449	8	he	he	PROPN
admet-2455	449	9	,	,	PUNCT
admet-2455	449	10	l.	l.	PROPN
admet-2455	449	11	luo	luo	PROPN
admet-2455	449	12	,	,	PUNCT
admet-2455	449	13	k.	k.	PROPN
admet-2455	449	14	wang	wang	PROPN
admet-2455	449	15	.	.	PUNCT
admet-2455	450	1	targeting	target	VERB
admet-2455	450	2	the	the	DET
admet-2455	450	3	interplay	interplay	NOUN
admet-2455	450	4	of	of	ADP
admet-2455	450	5	autophagy	autophagy	NOUN
admet-2455	450	6	and	and	CCONJ
admet-2455	450	7	ros	ros	PROPN
admet-2455	450	8	for	for	ADP
admet-2455	450	9	cancer	cancer	NOUN
admet-2455	450	10	therapy	therapy	NOUN
admet-2455	450	11	:	:	PUNCT
admet-2455	450	12	an	an	DET
admet-2455	450	13	updated	update	VERB
admet-2455	450	14	overview	overview	NOUN
admet-2455	450	15	on	on	ADP
admet-2455	450	16	phytochemicals	phytochemical	NOUN
admet-2455	450	17	.	.	PUNCT
admet-2455	451	1	pharmaceuticals	pharmaceutical	NOUN
admet-2455	451	2	(	(	PUNCT
admet-2455	451	3	basel	basel	PROPN
admet-2455	451	4	)	)	PUNCT
admet-2455	451	5	16	16	NUM
admet-2455	451	6	(	(	PUNCT
admet-2455	451	7	2023	2023	NUM
admet-2455	451	8	)	)	PUNCT
admet-2455	451	9	92	92	NUM
admet-2455	451	10	.	.	PUNCT
admet-2455	452	1	https://doi.org/10.3390/ph16010092	https://doi.org/10.3390/ph16010092	X
admet-2455	452	2	.	.	PUNCT
admet-2455	453	1	[	[	X
admet-2455	453	2	40	40	NUM
admet-2455	453	3	]	]	X
admet-2455	453	4	s.k	s.k	PROPN
admet-2455	453	5	.	.	PROPN
admet-2455	453	6	parks	parks	PROPN
admet-2455	453	7	,	,	PUNCT
admet-2455	453	8	w.	w.	PROPN
admet-2455	453	9	mueller	mueller	PROPN
admet-2455	453	10	-	-	PUNCT
admet-2455	453	11	klieser	klieser	PROPN
admet-2455	453	12	,	,	PUNCT
admet-2455	453	13	j.	j.	PROPN
admet-2455	453	14	pouyssegur	pouyssegur	PROPN
admet-2455	453	15	.	.	PUNCT
admet-2455	454	1	lactate	lactate	PROPN
admet-2455	454	2	and	and	CCONJ
admet-2455	454	3	acidity	acidity	NOUN
admet-2455	454	4	in	in	ADP
admet-2455	454	5	the	the	DET
admet-2455	454	6	cancer	cancer	NOUN
admet-2455	454	7	microenvironment	microenvironment	NOUN
admet-2455	454	8	.	.	PUNCT
admet-2455	455	1	annual	annual	ADJ
admet-2455	455	2	review	review	NOUN
admet-2455	455	3	of	of	ADP
admet-2455	455	4	cancer	cancer	NOUN
admet-2455	455	5	biology	biology	NOUN
admet-2455	455	6	,	,	PUNCT
admet-2455	455	7	vol	vol	NOUN
admet-2455	455	8	4	4	NUM
admet-2455	455	9	4	4	NUM
admet-2455	455	10	(	(	PUNCT
admet-2455	455	11	2020	2020	NUM
admet-2455	455	12	)	)	PUNCT
admet-2455	455	13	141	141	NUM
admet-2455	455	14	-	-	SYM
admet-2455	455	15	158	158	NUM
admet-2455	455	16	.	.	PUNCT
admet-2455	456	1	https://doi.org/10.1146/annurevcancerbio-030419-033556	https://doi.org/10.1146/annurevcancerbio-030419-033556	X
admet-2455	456	2	.	.	PUNCT
admet-2455	457	1	[	[	X
admet-2455	457	2	41	41	NUM
admet-2455	457	3	]	]	PUNCT
admet-2455	457	4	p.	p.	PROPN
admet-2455	457	5	wu	wu	PROPN
admet-2455	457	6	,	,	PUNCT
admet-2455	457	7	y.	y.	PROPN
admet-2455	457	8	zhou	zhou	PROPN
admet-2455	457	9	,	,	PUNCT
admet-2455	457	10	y.	y.	PROPN
admet-2455	457	11	guo	guo	PROPN
admet-2455	457	12	,	,	PUNCT
admet-2455	457	13	s.l	s.l	PROPN
admet-2455	457	14	.	.	PROPN
admet-2455	457	15	zhang	zhang	PROPN
admet-2455	457	16	,	,	PUNCT
admet-2455	457	17	k.y	k.y	PROPN
admet-2455	457	18	.	.	PROPN
admet-2455	457	19	tam	tam	PROPN
admet-2455	457	20	.	.	PUNCT
admet-2455	458	1	recent	recent	ADJ
admet-2455	458	2	developments	development	NOUN
admet-2455	458	3	of	of	ADP
admet-2455	458	4	human	human	ADJ
admet-2455	458	5	monocarboxylate	monocarboxylate	ADJ
admet-2455	458	6	transporter	transporter	NOUN
admet-2455	458	7	(	(	PUNCT
admet-2455	458	8	hmct	hmct	NOUN
admet-2455	458	9	)	)	PUNCT
admet-2455	458	10	inhibitors	inhibitor	NOUN
admet-2455	458	11	as	as	ADP
admet-2455	458	12	anticancer	anticancer	NOUN
admet-2455	458	13	agents	agent	NOUN
admet-2455	458	14	.	.	PUNCT
admet-2455	459	1	drug	drug	NOUN
admet-2455	459	2	discov	discov	PROPN
admet-2455	459	3	today	today	NOUN
admet-2455	459	4	26	26	NUM
admet-2455	459	5	(	(	PUNCT
admet-2455	459	6	2021	2021	NUM
admet-2455	459	7	)	)	PUNCT
admet-2455	459	8	836	836	NUM
admet-2455	459	9	-	-	SYM
admet-2455	459	10	844	844	NUM
admet-2455	459	11	.	.	PUNCT
admet-2455	459	12	https://doi.org/10.1016/j.drudis.2021.01.003	https://doi.org/10.1016/j.drudis.2021.01.003	NUM
admet-2455	459	13	.	.	PUNCT
admet-2455	460	1	[	[	X
admet-2455	460	2	42	42	NUM
admet-2455	460	3	]	]	X
admet-2455	460	4	h.k	h.k	PROPN
admet-2455	460	5	.	.	PROPN
admet-2455	460	6	matthews	matthews	PROPN
admet-2455	460	7	,	,	PUNCT
admet-2455	460	8	c.	c.	PROPN
admet-2455	460	9	bertoli	bertoli	PROPN
admet-2455	460	10	,	,	PUNCT
admet-2455	460	11	r.a.m	r.a.m	ADJ
admet-2455	460	12	.	.	PUNCT
admet-2455	460	13	de	de	X
admet-2455	460	14	bruin	bruin	NOUN
admet-2455	460	15	.	.	PUNCT
admet-2455	461	1	cell	cell	NOUN
admet-2455	461	2	cycle	cycle	NOUN
admet-2455	461	3	control	control	NOUN
admet-2455	461	4	in	in	ADP
admet-2455	461	5	cancer	cancer	NOUN
admet-2455	461	6	.	.	PUNCT
admet-2455	462	1	nat	nat	PROPN
admet-2455	462	2	rev	rev	VERB
admet-2455	462	3	mol	mol	ADP
admet-2455	462	4	cell	cell	NOUN
admet-2455	462	5	biol	biol	NOUN
admet-2455	462	6	23	23	NUM
admet-2455	462	7	(	(	PUNCT
admet-2455	462	8	2022	2022	NUM
admet-2455	462	9	)	)	PUNCT
admet-2455	462	10	74	74	NUM
admet-2455	462	11	-	-	SYM
admet-2455	462	12	88	88	NUM
admet-2455	462	13	.	.	PUNCT
admet-2455	463	1	https://doi.org/10.1038/s41580-021-00404-3	https://doi.org/10.1038/s41580-021-00404-3	PRON
admet-2455	463	2	.	.	PUNCT
admet-2455	464	1	[	[	X
admet-2455	464	2	43	43	NUM
admet-2455	464	3	]	]	X
admet-2455	464	4	s.	s.	PROPN
admet-2455	464	5	khan	khan	PROPN
admet-2455	464	6	,	,	PUNCT
admet-2455	464	7	z.	z.	PROPN
admet-2455	464	8	lopez	lopez	PROPN
admet-2455	464	9	-	-	PUNCT
admet-2455	464	10	dee	dee	PROPN
admet-2455	464	11	,	,	PUNCT
admet-2455	464	12	r.	r.	PROPN
admet-2455	464	13	kumar	kumar	PROPN
admet-2455	464	14	,	,	PUNCT
admet-2455	464	15	j.	j.	PROPN
admet-2455	464	16	ling	ling	PROPN
admet-2455	464	17	.	.	PUNCT
admet-2455	465	1	activation	activation	NOUN
admet-2455	465	2	of	of	ADP
admet-2455	465	3	nfkb	nfkb	PROPN
admet-2455	465	4	is	be	AUX
admet-2455	465	5	a	a	DET
admet-2455	465	6	novel	novel	ADJ
admet-2455	465	7	mechanism	mechanism	NOUN
admet-2455	465	8	of	of	ADP
admet-2455	465	9	pro	pro	ADJ
admet-2455	465	10	-	-	ADJ
admet-2455	465	11	survival	survival	ADJ
admet-2455	465	12	activity	activity	NOUN
admet-2455	465	13	of	of	ADP
admet-2455	465	14	glucocorticoids	glucocorticoid	NOUN
admet-2455	465	15	in	in	ADP
admet-2455	465	16	breast	breast	NOUN
admet-2455	465	17	cancer	cancer	NOUN
admet-2455	465	18	cells	cell	NOUN
admet-2455	465	19	.	.	PUNCT
admet-2455	466	1	cancer	cancer	NOUN
admet-2455	466	2	lett	lett	PROPN
admet-2455	466	3	337	337	NUM
admet-2455	466	4	(	(	PUNCT
admet-2455	466	5	2013	2013	NUM
admet-2455	466	6	)	)	PUNCT
admet-2455	466	7	90	90	NUM
admet-2455	466	8	-	-	SYM
admet-2455	466	9	95	95	NUM
admet-2455	466	10	.	.	PUNCT
admet-2455	467	1	https://doi.org/10.1016/j.canlet.2013.05.020	https://doi.org/10.1016/j.canlet.2013.05.020	NOUN
admet-2455	467	2	.	.	PUNCT
admet-2455	468	1	[	[	X
admet-2455	468	2	44	44	NUM
admet-2455	468	3	]	]	PUNCT
admet-2455	468	4	k.	k.	PROPN
admet-2455	468	5	taniguchi	taniguchi	PROPN
admet-2455	468	6	,	,	PUNCT
admet-2455	468	7	m.	m.	PROPN
admet-2455	468	8	karin	karin	PROPN
admet-2455	468	9	.	.	PUNCT
admet-2455	469	1	nf	nf	PROPN
admet-2455	469	2	-	-	PUNCT
admet-2455	469	3	kappab	kappab	NOUN
admet-2455	469	4	,	,	PUNCT
admet-2455	469	5	inflammation	inflammation	NOUN
admet-2455	469	6	,	,	PUNCT
admet-2455	469	7	immunity	immunity	NOUN
admet-2455	469	8	and	and	CCONJ
admet-2455	469	9	cancer	cancer	NOUN
admet-2455	469	10	:	:	PUNCT
admet-2455	469	11	coming	come	VERB
admet-2455	469	12	of	of	ADP
admet-2455	469	13	age	age	NOUN
admet-2455	469	14	.	.	PUNCT
admet-2455	470	1	nat	nat	PROPN
admet-2455	470	2	rev	rev	VERB
admet-2455	470	3	immunol	immunol	NOUN
admet-2455	470	4	18	18	NUM
admet-2455	470	5	(	(	PUNCT
admet-2455	470	6	2018	2018	NUM
admet-2455	470	7	)	)	PUNCT
admet-2455	470	8	309	309	NUM
admet-2455	470	9	-	-	SYM
admet-2455	470	10	324	324	NUM
admet-2455	470	11	.	.	PUNCT
admet-2455	471	1	https://doi.org/10.1038/nri.2017.142	https://doi.org/10.1038/nri.2017.142	PROPN
admet-2455	471	2	.	.	PUNCT
admet-2455	472	1	https://doi.org/10.1158/0008-5472.can-09-1947	https://doi.org/10.1158/0008-5472.can-09-1947	X
admet-2455	473	1	https://doi.org/10.21873/anticanres.13472	https://doi.org/10.21873/anticanres.13472	X
admet-2455	474	1	https://doi.org/10.1101/pdb.prot083733	https://doi.org/10.1101/pdb.prot083733	X
admet-2455	474	2	https://doi.org/10.1177/1533033819871306	https://doi.org/10.1177/1533033819871306	VERB
admet-2455	474	3	https://doi.org/10.1155/2022/1452861	https://doi.org/10.1155/2022/1452861	PROPN
admet-2455	474	4	https://doi.org/10.1016/j.ccr.2013.06.014	https://doi.org/10.1016/j.ccr.2013.06.014	VERB
admet-2455	474	5	https://doi.org/10.2174/0929867326666181213092652	https://doi.org/10.2174/0929867326666181213092652	PROPN
admet-2455	474	6	https://doi.org/10.1146/annurev-cancerbio-041916-065808	https://doi.org/10.1146/annurev-cancerbio-041916-065808	PROPN
admet-2455	474	7	https://doi.org/10.1002/ijc.31069	https://doi.org/10.1002/ijc.31069	PROPN
admet-2455	474	8	https://doi.org/10.4331/wjbc.v6.i3.148	https://doi.org/10.4331/wjbc.v6.i3.148	NOUN
admet-2455	474	9	https://doi.org/10.1080/21655979.2021.1930335	https://doi.org/10.1080/21655979.2021.1930335	NOUN
admet-2455	475	1	https://doi.org/10.1016/j.jphs.2016.03.001	https://doi.org/10.1016/j.jphs.2016.03.001	NOUN
admet-2455	475	2	https://doi.org/10.3390/ph16010092	https://doi.org/10.3390/ph16010092	X
admet-2455	475	3	https://doi.org/10.1146/annurev-cancerbio-030419-033556	https://doi.org/10.1146/annurev-cancerbio-030419-033556	PROPN
admet-2455	475	4	https://doi.org/10.1146/annurev-cancerbio-030419-033556	https://doi.org/10.1146/annurev-cancerbio-030419-033556	PROPN
admet-2455	475	5	https://doi.org/10.1016/j.drudis.2021.01.003	https://doi.org/10.1016/j.drudis.2021.01.003	PROPN
admet-2455	475	6	https://doi.org/10.1038/s41580-021-00404-3	https://doi.org/10.1038/s41580-021-00404-3	NOUN
admet-2455	475	7	https://doi.org/10.1016/j.canlet.2013.05.020	https://doi.org/10.1016/j.canlet.2013.05.020	NOUN
admet-2455	475	8	https://doi.org/10.1038/nri.2017.142	https://doi.org/10.1038/nri.2017.142	PROPN
admet-2455	475	9	admet	admet	PROPN
admet-2455	475	10	&	&	CCONJ
admet-2455	475	11	dmpk	dmpk	PROPN
admet-2455	475	12	12(6	12(6	NUM
admet-2455	475	13	)	)	PUNCT
admet-2455	475	14	(	(	PUNCT
admet-2455	475	15	2024	2024	NUM
admet-2455	475	16	)	)	PUNCT
admet-2455	475	17	821	821	NUM
admet-2455	475	18	-	-	SYM
admet-2455	475	19	841	841	NUM
admet-2455	475	20	targeting	targeting	NOUN
admet-2455	475	21	hexokinase	hexokinase	NOUN
admet-2455	475	22	2	2	NUM
admet-2455	475	23	to	to	PART
admet-2455	475	24	enhance	enhance	VERB
admet-2455	475	25	anticancer	anticancer	NOUN
admet-2455	475	26	efficacy	efficacy	NOUN
admet-2455	475	27	of	of	ADP
admet-2455	475	28	trichosanthin	trichosanthin	PROPN
admet-2455	475	29	doi	doi	PROPN
admet-2455	475	30	:	:	PUNCT
admet-2455	475	31	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	X
admet-2455	475	32	841	841	NUM
admet-2455	476	1	[	[	SYM
admet-2455	476	2	45	45	NUM
admet-2455	476	3	]	]	PUNCT
admet-2455	476	4	b.	b.	PROPN
admet-2455	476	5	wei	wei	PROPN
admet-2455	476	6	,	,	PUNCT
admet-2455	476	7	q.	q.	PROPN
admet-2455	476	8	huang	huang	PROPN
admet-2455	476	9	,	,	PUNCT
admet-2455	476	10	s.	s.	PROPN
admet-2455	476	11	huang	huang	PROPN
admet-2455	476	12	,	,	PUNCT
admet-2455	476	13	w.	w.	PROPN
admet-2455	476	14	mai	mai	PROPN
admet-2455	476	15	,	,	PUNCT
admet-2455	476	16	x.	x.	PROPN
admet-2455	476	17	zhong	zhong	PROPN
admet-2455	476	18	.	.	PROPN
admet-2455	476	19	trichosanthin	trichosanthin	PROPN
admet-2455	476	20	-	-	PUNCT
admet-2455	476	21	induced	induce	VERB
admet-2455	476	22	autophagy	autophagy	NOUN
admet-2455	476	23	in	in	ADP
admet-2455	476	24	gastric	gastric	ADJ
admet-2455	476	25	cancer	cancer	NOUN
admet-2455	476	26	cell	cell	NOUN
admet-2455	476	27	mkn-45	mkn-45	CCONJ
admet-2455	476	28	is	be	AUX
admet-2455	476	29	dependent	dependent	ADJ
admet-2455	476	30	on	on	ADP
admet-2455	476	31	reactive	reactive	ADJ
admet-2455	476	32	oxygen	oxygen	NOUN
admet-2455	476	33	species	specie	NOUN
admet-2455	476	34	(	(	PUNCT
admet-2455	476	35	ros	ros	PROPN
admet-2455	476	36	)	)	PUNCT
admet-2455	476	37	and	and	CCONJ
admet-2455	476	38	nf	nf	NOUN
admet-2455	476	39	-	-	PUNCT
admet-2455	476	40	κb	κb	NOUN
admet-2455	476	41	/	/	SYM
admet-2455	476	42	p53	p53	NOUN
admet-2455	476	43	pathway	pathway	NOUN
admet-2455	476	44	.	.	PUNCT
admet-2455	477	1	j	j	PROPN
admet-2455	477	2	pharmacol	pharmacol	PROPN
admet-2455	477	3	sci	sci	PROPN
admet-2455	477	4	131	131	NUM
admet-2455	477	5	(	(	PUNCT
admet-2455	477	6	2016	2016	NUM
admet-2455	477	7	)	)	PUNCT
admet-2455	477	8	77	77	NUM
admet-2455	477	9	-	-	SYM
admet-2455	477	10	83	83	NUM
admet-2455	477	11	.	.	PUNCT
admet-2455	478	1	https://doi.org/10.1016/j.jphs.2016.03.001	https://doi.org/10.1016/j.jphs.2016.03.001	VERB
admet-2455	478	2	.	.	PUNCT
admet-2455	479	1	[	[	X
admet-2455	479	2	46	46	NUM
admet-2455	479	3	]	]	X
admet-2455	479	4	d.	d.	PROPN
admet-2455	479	5	verzella	verzella	PROPN
admet-2455	479	6	,	,	PUNCT
admet-2455	479	7	a.	a.	NOUN
admet-2455	479	8	pescatore	pescatore	PROPN
admet-2455	479	9	,	,	PUNCT
admet-2455	479	10	d.	d.	PROPN
admet-2455	479	11	capece	capece	PROPN
admet-2455	479	12	,	,	PUNCT
admet-2455	479	13	d.	d.	PROPN
admet-2455	479	14	vecchiotti	vecchiotti	PROPN
admet-2455	479	15	,	,	PUNCT
admet-2455	479	16	m.v	m.v	PROPN
admet-2455	479	17	.	.	PROPN
admet-2455	479	18	ursini	ursini	PROPN
admet-2455	479	19	,	,	PUNCT
admet-2455	479	20	g.	g.	PROPN
admet-2455	479	21	franzoso	franzoso	NOUN
admet-2455	479	22	,	,	PUNCT
admet-2455	479	23	e.	e.	PROPN
admet-2455	479	24	alesse	alesse	PROPN
admet-2455	479	25	,	,	PUNCT
admet-2455	479	26	f.	f.	PROPN
admet-2455	479	27	zazzeroni	zazzeroni	PROPN
admet-2455	479	28	.	.	PUNCT
admet-2455	480	1	life	life	NOUN
admet-2455	480	2	,	,	PUNCT
admet-2455	480	3	death	death	NOUN
admet-2455	480	4	,	,	PUNCT
admet-2455	480	5	and	and	CCONJ
admet-2455	480	6	autophagy	autophagy	VERB
admet-2455	480	7	in	in	ADP
admet-2455	480	8	cancer	cancer	NOUN
admet-2455	480	9	:	:	PUNCT
admet-2455	480	10	nf	nf	ADJ
admet-2455	480	11	-	-	PUNCT
admet-2455	480	12	κb	κb	NOUN
admet-2455	480	13	turns	turn	VERB
admet-2455	480	14	up	up	ADV
admet-2455	480	15	everywhere	everywhere	ADV
admet-2455	480	16	.	.	PUNCT
admet-2455	481	1	cell	cell	NOUN
admet-2455	481	2	death	death	NOUN
admet-2455	481	3	dis	dis	PROPN
admet-2455	481	4	11	11	NUM
admet-2455	481	5	(	(	PUNCT
admet-2455	481	6	2020	2020	NUM
admet-2455	481	7	)	)	PUNCT
admet-2455	481	8	210	210	NUM
admet-2455	481	9	.	.	PUNCT
admet-2455	482	1	https://doi.org/10.1038/s41419-020-2399-y	https://doi.org/10.1038/s41419-020-2399-y	INTJ
admet-2455	482	2	.	.	PUNCT
admet-2455	483	1	[	[	X
admet-2455	483	2	47	47	NUM
admet-2455	483	3	]	]	X
admet-2455	483	4	y.	y.	PROPN
admet-2455	483	5	chang	chang	PROPN
admet-2455	483	6	,	,	PUNCT
admet-2455	483	7	w.	w.	PROPN
admet-2455	483	8	xiong	xiong	PROPN
admet-2455	483	9	,	,	PUNCT
admet-2455	483	10	c.	c.	PROPN
admet-2455	483	11	zou	zou	PROPN
admet-2455	483	12	,	,	PUNCT
admet-2455	483	13	p.	p.	PROPN
admet-2455	483	14	zeng	zeng	PROPN
admet-2455	483	15	,	,	PUNCT
admet-2455	483	16	j.	j.	PROPN
admet-2455	483	17	hou	hou	PROPN
admet-2455	483	18	,	,	PUNCT
admet-2455	483	19	b.	b.	PROPN
admet-2455	483	20	muhitdinov	muhitdinov	PROPN
admet-2455	483	21	,	,	PUNCT
admet-2455	483	22	y.	y.	PROPN
admet-2455	483	23	shen	shen	PROPN
admet-2455	483	24	,	,	PUNCT
admet-2455	483	25	y.	y.	PROPN
admet-2455	483	26	huang	huang	PROPN
admet-2455	483	27	,	,	PUNCT
admet-2455	483	28	s.	s.	PROPN
admet-2455	483	29	guo	guo	PROPN
admet-2455	483	30	.	.	PUNCT
admet-2455	483	31	mitigation	mitigation	NOUN
admet-2455	483	32	of	of	ADP
admet-2455	483	33	anti	anti	ADJ
admet-2455	483	34	-	-	ADJ
admet-2455	483	35	drug	drug	ADJ
admet-2455	483	36	antibody	antibody	NOUN
admet-2455	483	37	production	production	NOUN
admet-2455	483	38	for	for	ADP
admet-2455	483	39	augmenting	augment	VERB
admet-2455	483	40	anticancer	anticancer	NOUN
admet-2455	483	41	efficacy	efficacy	NOUN
admet-2455	483	42	of	of	ADP
admet-2455	483	43	therapeutic	therapeutic	ADJ
admet-2455	483	44	protein	protein	NOUN
admet-2455	483	45	via	via	ADP
admet-2455	483	46	coinjection	coinjection	NOUN
admet-2455	483	47	of	of	ADP
admet-2455	483	48	nano	nano	NOUN
admet-2455	483	49	-	-	PUNCT
admet-2455	483	50	rapamycin	rapamycin	NOUN
admet-2455	483	51	.	.	PUNCT
admet-2455	484	1	small	small	ADJ
admet-2455	484	2	(	(	PUNCT
admet-2455	484	3	2023	2023	NUM
admet-2455	484	4	)	)	PUNCT
admet-2455	484	5	e2303916	e2303916	PROPN
admet-2455	484	6	.	.	PUNCT
admet-2455	485	1	https://doi.org/10.1002/smll.202303916	https://doi.org/10.1002/smll.202303916	PROPN
admet-2455	485	2	.	.	PUNCT
admet-2455	486	1	[	[	X
admet-2455	486	2	48	48	NUM
admet-2455	486	3	]	]	PUNCT
admet-2455	486	4	z.	z.	PROPN
admet-2455	486	5	setayesh	setayesh	PROPN
admet-2455	486	6	-	-	PUNCT
admet-2455	486	7	mehr	mehr	NOUN
admet-2455	486	8	,	,	PUNCT
admet-2455	486	9	m.	m.	NOUN
admet-2455	486	10	poorsargol	poorsargol	NOUN
admet-2455	486	11	.	.	PUNCT
admet-2455	487	1	toxic	toxic	ADJ
admet-2455	487	2	proteins	protein	NOUN
admet-2455	487	3	application	application	NOUN
admet-2455	487	4	in	in	ADP
admet-2455	487	5	cancer	cancer	NOUN
admet-2455	487	6	therapy	therapy	NOUN
admet-2455	487	7	.	.	PUNCT
admet-2455	488	1	mol	mol	ADP
admet-2455	488	2	biol	biol	PROPN
admet-2455	488	3	rep	rep	PROPN
admet-2455	488	4	48	48	NUM
admet-2455	488	5	(	(	PUNCT
admet-2455	488	6	2021	2021	NUM
admet-2455	488	7	)	)	PUNCT
admet-2455	488	8	3827	3827	NUM
admet-2455	488	9	-	-	SYM
admet-2455	488	10	3840	3840	NUM
admet-2455	488	11	.	.	PUNCT
admet-2455	489	1	https://doi.org/10.1007/s11033-021-06363-4	https://doi.org/10.1007/s11033-021-06363-4	PROPN
admet-2455	489	2	.	.	PUNCT
admet-2455	490	1	©	©	ADP
admet-2455	490	2	2024	2024	NUM
admet-2455	490	3	by	by	ADP
admet-2455	490	4	the	the	DET
admet-2455	490	5	authors	author	NOUN
admet-2455	490	6	;	;	PUNCT
admet-2455	490	7	licensee	licensee	PROPN
admet-2455	490	8	iapc	iapc	PROPN
admet-2455	490	9	,	,	PUNCT
admet-2455	490	10	zagreb	zagreb	PROPN
admet-2455	490	11	,	,	PUNCT
admet-2455	490	12	croatia	croatia	PROPN
admet-2455	490	13	.	.	PUNCT
admet-2455	491	1	this	this	DET
admet-2455	491	2	article	article	NOUN
admet-2455	491	3	is	be	AUX
admet-2455	491	4	an	an	DET
admet-2455	491	5	open	open	ADJ
admet-2455	491	6	-	-	PUNCT
admet-2455	491	7	access	access	NOUN
admet-2455	491	8	article	article	NOUN
admet-2455	491	9	distributed	distribute	VERB
admet-2455	491	10	under	under	ADP
admet-2455	491	11	the	the	DET
admet-2455	491	12	terms	term	NOUN
admet-2455	491	13	and	and	CCONJ
admet-2455	491	14	conditions	condition	NOUN
admet-2455	491	15	of	of	ADP
admet-2455	491	16	the	the	DET
admet-2455	491	17	creative	creative	ADJ
admet-2455	491	18	commons	common	NOUN
admet-2455	491	19	attribution	attribution	NOUN
admet-2455	491	20	license	license	NOUN
admet-2455	491	21	(	(	PUNCT
admet-2455	491	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2455	491	23	)	)	PUNCT
admet-2455	491	24	https://doi.org/10.5599/admet.2455	https://doi.org/10.5599/admet.2455	PRON
admet-2455	491	25	https://doi.org/10.1016/j.jphs.2016.03.001	https://doi.org/10.1016/j.jphs.2016.03.001	VERB
admet-2455	491	26	https://doi.org/10.1038/s41419-020-2399-y	https://doi.org/10.1038/s41419-020-2399-y	PROPN
admet-2455	491	27	https://doi.org/10.1002/smll.202303916	https://doi.org/10.1002/smll.202303916	ADJ
admet-2455	491	28	https://doi.org/10.1007/s11033-021-06363-4	https://doi.org/10.1007/s11033-021-06363-4	NUM
admet-2455	492	1	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN