id	sid	tid	token	lemma	pos
admet-247	1	1	manuscript	manuscript	PROPN
admet-247	1	2	doi	doi	PROPN
admet-247	1	3	:	:	PUNCT
admet-247	1	4	10.5599	10.5599	NUM
admet-247	1	5	/	/	SYM
admet-247	1	6	admet.3.4.247	admet.3.4.247	PROPN
admet-247	1	7	345	345	NUM
admet-247	1	8	admet	admet	X
admet-247	1	9	&	&	CCONJ
admet-247	1	10	dmpk	dmpk	PROPN
admet-247	1	11	3(4	3(4	NUM
admet-247	1	12	)	)	PUNCT
admet-247	1	13	(	(	PUNCT
admet-247	1	14	2015	2015	NUM
admet-247	1	15	)	)	PUNCT
admet-247	1	16	345	345	NUM
admet-247	1	17	-	-	SYM
admet-247	1	18	351	351	NUM
admet-247	1	19	;	;	PUNCT
admet-247	1	20	doi	doi	NOUN
admet-247	1	21	:	:	PUNCT
admet-247	1	22	10.5599	10.5599	NUM
admet-247	1	23	/	/	SYM
admet-247	1	24	admet.3.4.247	admet.3.4.247	NOUN
admet-247	1	25	open	open	ADJ
admet-247	1	26	access	access	NOUN
admet-247	1	27	:	:	PUNCT
admet-247	1	28	issn	issn	PROPN
admet-247	1	29	:	:	PUNCT
admet-247	1	30	1848	1848	NUM
admet-247	1	31	-	-	SYM
admet-247	1	32	7718	7718	NUM
admet-247	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-247	1	34	original	original	ADJ
admet-247	1	35	scientific	scientific	ADJ
admet-247	1	36	paper	paper	NOUN
admet-247	1	37	permeation	permeation	NOUN
admet-247	1	38	of	of	ADP
admet-247	1	39	indomethacin	indomethacin	NOUN
admet-247	1	40	through	through	ADP
admet-247	1	41	skin	skin	NOUN
admet-247	1	42	using	use	VERB
admet-247	1	43	nanonized	nanonize	VERB
admet-247	1	44	alaptide	alaptide	PROPN
admet-247	1	45	aneta	aneta	PROPN
admet-247	1	46	cernikova	cernikova	PROPN
admet-247	1	47	,	,	PUNCT
admet-247	1	48	jiri	jiri	PROPN
admet-247	1	49	dohnal	dohnal	PROPN
admet-247	1	50	and	and	CCONJ
admet-247	1	51	josef	josef	PROPN
admet-247	1	52	jampilek	jampilek	PROPN
admet-247	1	53	*	*	PROPN
admet-247	1	54	department	department	PROPN
admet-247	1	55	of	of	ADP
admet-247	1	56	chemical	chemical	NOUN
admet-247	1	57	drugs	drug	NOUN
admet-247	1	58	,	,	PUNCT
admet-247	1	59	faculty	faculty	NOUN
admet-247	1	60	of	of	ADP
admet-247	1	61	pharmacy	pharmacy	NOUN
admet-247	1	62	,	,	PUNCT
admet-247	1	63	university	university	NOUN
admet-247	1	64	of	of	ADP
admet-247	1	65	veterinary	veterinary	ADJ
admet-247	1	66	and	and	CCONJ
admet-247	1	67	pharmaceutical	pharmaceutical	NOUN
admet-247	1	68	sciences	science	NOUN
admet-247	1	69	brno	brno	NOUN
admet-247	1	70	,	,	PUNCT
admet-247	1	71	palackeho	palackeho	VERB
admet-247	1	72	1/3	1/3	NUM
admet-247	1	73	,	,	PUNCT
admet-247	1	74	61242	61242	NUM
admet-247	1	75	brno	brno	NOUN
admet-247	1	76	,	,	PUNCT
admet-247	1	77	czech	czech	PROPN
admet-247	1	78	republic	republic	NOUN
admet-247	1	79	*	*	PUNCT
admet-247	1	80	corresponding	correspond	VERB
admet-247	1	81	author	author	NOUN
admet-247	1	82	:	:	PUNCT
admet-247	1	83	e	e	NOUN
admet-247	1	84	-	-	NOUN
admet-247	1	85	mail	mail	NOUN
admet-247	1	86	:	:	PUNCT
admet-247	1	87	josef.jampilek@gmail.com	josef.jampilek@gmail.com	X
admet-247	1	88	;	;	PUNCT
admet-247	1	89	tel	tel	PROPN
admet-247	1	90	.	.	PROPN
admet-247	1	91	:	:	PUNCT
admet-247	2	1	+420	+420	NUM
admet-247	2	2	-	-	SYM
admet-247	2	3	541	541	NUM
admet-247	2	4	-	-	PUNCT
admet-247	2	5	562	562	NUM
admet-247	2	6	-	-	PUNCT
admet-247	2	7	926	926	NUM
admet-247	2	8	received	receive	VERB
admet-247	2	9	:	:	PUNCT
admet-247	2	10	october	october	PROPN
admet-247	2	11	28	28	NUM
admet-247	2	12	,	,	PUNCT
admet-247	2	13	2015	2015	NUM
admet-247	2	14	;	;	PUNCT
admet-247	2	15	revised	revise	VERB
admet-247	2	16	:	:	PUNCT
admet-247	2	17	november	november	PROPN
admet-247	2	18	22	22	NUM
admet-247	2	19	,	,	PUNCT
admet-247	2	20	2015	2015	NUM
admet-247	2	21	;	;	PUNCT
admet-247	2	22	published	publish	VERB
admet-247	2	23	:	:	PUNCT
admet-247	2	24	december	december	PROPN
admet-247	2	25	30	30	NUM
admet-247	2	26	,	,	PUNCT
admet-247	2	27	2015	2015	NUM
admet-247	2	28	abstract	abstract	ADJ
admet-247	2	29	alaptide	alaptide	NOUN
admet-247	2	30	,	,	PUNCT
admet-247	2	31	(	(	PUNCT
admet-247	2	32	s)-8	s)-8	NOUN
admet-247	2	33	-	-	PUNCT
admet-247	2	34	methyl-6,9	methyl-6,9	NUM
admet-247	2	35	-	-	PUNCT
admet-247	2	36	diazaspiro[4.5]decan-7,10	diazaspiro[4.5]decan-7,10	NOUN
admet-247	2	37	-	-	PUNCT
admet-247	2	38	dione	dione	NOUN
admet-247	2	39	,	,	PUNCT
admet-247	2	40	is	be	AUX
admet-247	2	41	an	an	DET
admet-247	2	42	original	original	ADJ
admet-247	2	43	czech	czech	NOUN
admet-247	2	44	compound	compound	NOUN
admet-247	2	45	;	;	PUNCT
admet-247	2	46	in	in	ADP
admet-247	2	47	this	this	DET
admet-247	2	48	paper	paper	NOUN
admet-247	2	49	it	it	PRON
admet-247	2	50	is	be	AUX
admet-247	2	51	used	use	VERB
admet-247	2	52	as	as	ADP
admet-247	2	53	an	an	DET
admet-247	2	54	excipient	excipient	NOUN
admet-247	2	55	.	.	PUNCT
admet-247	3	1	the	the	DET
admet-247	3	2	investigation	investigation	NOUN
admet-247	3	3	deals	deal	VERB
admet-247	3	4	with	with	ADP
admet-247	3	5	the	the	DET
admet-247	3	6	affection	affection	NOUN
admet-247	3	7	of	of	ADP
admet-247	3	8	the	the	DET
admet-247	3	9	permeation	permeation	NOUN
admet-247	3	10	of	of	ADP
admet-247	3	11	indomethacin	indomethacin	NOUN
admet-247	3	12	through	through	ADP
admet-247	3	13	full	full	ADJ
admet-247	3	14	-	-	PUNCT
admet-247	3	15	thickness	thickness	NOUN
admet-247	3	16	pig	pig	NOUN
admet-247	3	17	ear	ear	VERB
admet-247	3	18	skin	skin	NOUN
admet-247	3	19	using	use	VERB
admet-247	3	20	a	a	DET
admet-247	3	21	franz	franz	NOUN
admet-247	3	22	diffusion	diffusion	NOUN
admet-247	3	23	cell	cell	NOUN
admet-247	3	24	from	from	ADP
admet-247	3	25	the	the	DET
admet-247	3	26	donor	donor	NOUN
admet-247	3	27	vehicle	vehicle	NOUN
admet-247	3	28	of	of	ADP
admet-247	3	29	propylene	propylene	NOUN
admet-247	3	30	glycol	glycol	NOUN
admet-247	3	31	/	/	SYM
admet-247	3	32	water	water	NOUN
admet-247	3	33	(	(	PUNCT
admet-247	3	34	1:1	1:1	NUM
admet-247	3	35	)	)	PUNCT
admet-247	3	36	using	use	VERB
admet-247	3	37	nanonized	nanonized	ADJ
admet-247	3	38	alaptide	alaptide	NOUN
admet-247	3	39	as	as	ADP
admet-247	3	40	a	a	DET
admet-247	3	41	potential	potential	ADJ
admet-247	3	42	transdermal	transdermal	ADJ
admet-247	3	43	permeation	permeation	NOUN
admet-247	3	44	enhancer	enhancer	NOUN
admet-247	3	45	.	.	PUNCT
admet-247	4	1	alaptide	alaptide	PROPN
admet-247	4	2	was	be	AUX
admet-247	4	3	applied	apply	VERB
admet-247	4	4	in	in	ADP
admet-247	4	5	ratio	ratio	NOUN
admet-247	4	6	1:10	1:10	NUM
admet-247	4	7	(	(	PUNCT
admet-247	4	8	w	w	PROPN
admet-247	4	9	/	/	SYM
admet-247	4	10	w	w	NOUN
admet-247	4	11	)	)	PUNCT
admet-247	4	12	related	relate	VERB
admet-247	4	13	to	to	ADP
admet-247	4	14	the	the	DET
admet-247	4	15	amount	amount	NOUN
admet-247	4	16	of	of	ADP
admet-247	4	17	indomethacin	indomethacin	PROPN
admet-247	4	18	.	.	PUNCT
admet-247	5	1	nanonized	nanonize	VERB
admet-247	5	2	alaptide	alaptide	NOUN
admet-247	5	3	showed	show	VERB
admet-247	5	4	an	an	DET
admet-247	5	5	excellent	excellent	ADJ
admet-247	5	6	rapid	rapid	ADJ
admet-247	5	7	onset	onset	NOUN
admet-247	5	8	of	of	ADP
admet-247	5	9	enhancement	enhancement	NOUN
admet-247	5	10	effect	effect	NOUN
admet-247	5	11	,	,	PUNCT
admet-247	5	12	already	already	ADV
admet-247	5	13	at	at	ADP
admet-247	5	14	the	the	DET
admet-247	5	15	30	30	NUM
admet-247	5	16	th	th	NOUN
admet-247	5	17	minute	minute	NOUN
admet-247	5	18	after	after	ADP
admet-247	5	19	application	application	NOUN
admet-247	5	20	,	,	PUNCT
admet-247	5	21	when	when	SCONJ
admet-247	5	22	the	the	DET
admet-247	5	23	permeated	permeate	VERB
admet-247	5	24	amount	amount	NOUN
admet-247	5	25	of	of	ADP
admet-247	5	26	indomethacin	indomethacin	NOUN
admet-247	5	27	was	be	AUX
admet-247	5	28	5	5	NUM
admet-247	5	29	-	-	NOUN
admet-247	5	30	fold	fold	VERB
admet-247	5	31	more	more	ADV
admet-247	5	32	than	than	ADP
admet-247	5	33	in	in	ADP
admet-247	5	34	the	the	DET
admet-247	5	35	formulation	formulation	NOUN
admet-247	5	36	without	without	ADP
admet-247	5	37	alaptide	alaptide	NOUN
admet-247	5	38	.	.	PUNCT
admet-247	6	1	the	the	DET
admet-247	6	2	enhancement	enhancement	NOUN
admet-247	6	3	ratio	ratio	NOUN
admet-247	6	4	of	of	ADP
admet-247	6	5	nanonized	nanonized	ADJ
admet-247	6	6	alaptide	alaptide	NOUN
admet-247	6	7	was	be	AUX
admet-247	6	8	5.6	5.6	NUM
admet-247	6	9	,	,	PUNCT
admet-247	6	10	which	which	PRON
admet-247	6	11	indicates	indicate	VERB
admet-247	6	12	that	that	SCONJ
admet-247	6	13	alaptide	alaptide	NOUN
admet-247	6	14	modifies	modify	VERB
admet-247	6	15	skin	skin	NOUN
admet-247	6	16	structure	structure	NOUN
admet-247	6	17	,	,	PUNCT
admet-247	6	18	which	which	PRON
admet-247	6	19	results	result	VERB
admet-247	6	20	in	in	ADP
admet-247	6	21	significantly	significantly	ADV
admet-247	6	22	enhanced	enhance	VERB
admet-247	6	23	permeation	permeation	NOUN
admet-247	6	24	at	at	ADP
admet-247	6	25	long	long	ADJ
admet-247	6	26	-	-	PUNCT
admet-247	6	27	term	term	NOUN
admet-247	6	28	application	application	NOUN
admet-247	6	29	.	.	PUNCT
admet-247	7	1	keywords	keyword	NOUN
admet-247	7	2	alaptide	alaptide	ADV
admet-247	7	3	;	;	PUNCT
admet-247	7	4	indomethacin	indomethacin	NOUN
admet-247	7	5	;	;	PUNCT
admet-247	7	6	nanoparticles	nanoparticle	NOUN
admet-247	7	7	;	;	PUNCT
admet-247	7	8	permeation	permeation	NOUN
admet-247	7	9	;	;	PUNCT
admet-247	7	10	skin	skin	NOUN
admet-247	7	11	.	.	PUNCT
admet-247	8	1	introduction	introduction	NOUN
admet-247	8	2	transdermal	transdermal	ADJ
admet-247	8	3	administration	administration	NOUN
admet-247	8	4	of	of	ADP
admet-247	8	5	drugs	drug	NOUN
admet-247	8	6	can	can	AUX
admet-247	8	7	be	be	AUX
admet-247	8	8	considered	consider	VERB
admet-247	8	9	as	as	ADP
admet-247	8	10	an	an	DET
admet-247	8	11	alternative	alternative	NOUN
admet-247	8	12	to	to	ADP
admet-247	8	13	conventional	conventional	ADJ
admet-247	8	14	pharmaceutical	pharmaceutical	ADJ
admet-247	8	15	dosage	dosage	NOUN
admet-247	8	16	forms	form	NOUN
admet-247	8	17	.	.	PUNCT
admet-247	9	1	nevertheless	nevertheless	ADV
admet-247	9	2	,	,	PUNCT
admet-247	9	3	a	a	DET
admet-247	9	4	frequent	frequent	ADJ
admet-247	9	5	problem	problem	NOUN
admet-247	9	6	of	of	ADP
admet-247	9	7	transdermal	transdermal	ADJ
admet-247	9	8	drug	drug	NOUN
admet-247	9	9	delivery	delivery	NOUN
admet-247	9	10	is	be	AUX
admet-247	9	11	insufficient	insufficient	ADJ
admet-247	9	12	or	or	CCONJ
admet-247	9	13	no	no	DET
admet-247	9	14	penetration	penetration	NOUN
admet-247	9	15	of	of	ADP
admet-247	9	16	active	active	ADJ
admet-247	9	17	pharmaceutical	pharmaceutical	ADJ
admet-247	9	18	substances	substance	NOUN
admet-247	9	19	through	through	ADP
admet-247	9	20	the	the	DET
admet-247	9	21	skin	skin	NOUN
admet-247	9	22	,	,	PUNCT
admet-247	9	23	and	and	CCONJ
admet-247	9	24	thus	thus	ADV
admet-247	9	25	various	various	ADJ
admet-247	9	26	approaches	approach	NOUN
admet-247	9	27	to	to	ADP
admet-247	9	28	overcoming	overcome	VERB
admet-247	9	29	the	the	DET
admet-247	9	30	skin	skin	NOUN
admet-247	9	31	barrier	barrier	NOUN
admet-247	9	32	was	be	AUX
admet-247	9	33	to	to	PART
admet-247	9	34	be	be	AUX
admet-247	9	35	developed	develop	VERB
admet-247	9	36	.	.	PUNCT
admet-247	10	1	these	these	DET
admet-247	10	2	approaches	approach	NOUN
admet-247	10	3	can	can	AUX
admet-247	10	4	be	be	AUX
admet-247	10	5	based	base	VERB
admet-247	10	6	on	on	ADP
admet-247	10	7	an	an	DET
admet-247	10	8	optimization	optimization	NOUN
admet-247	10	9	of	of	ADP
admet-247	10	10	a	a	DET
admet-247	10	11	drug	drug	NOUN
admet-247	10	12	/	/	SYM
admet-247	10	13	vehicle	vehicle	NOUN
admet-247	10	14	system	system	NOUN
admet-247	10	15	or	or	CCONJ
admet-247	10	16	modification	modification	NOUN
admet-247	10	17	of	of	ADP
admet-247	10	18	stratum	stratum	NOUN
admet-247	10	19	corneum	corneum	NOUN
admet-247	10	20	(	(	PUNCT
admet-247	10	21	which	which	PRON
admet-247	10	22	is	be	AUX
admet-247	10	23	the	the	DET
admet-247	10	24	outermost	outermost	ADJ
admet-247	10	25	layer	layer	NOUN
admet-247	10	26	of	of	ADP
admet-247	10	27	the	the	DET
admet-247	10	28	skin	skin	NOUN
admet-247	10	29	responsible	responsible	ADJ
admet-247	10	30	for	for	ADP
admet-247	10	31	barrier	barrier	NOUN
admet-247	10	32	function	function	NOUN
admet-247	10	33	and	and	CCONJ
admet-247	10	34	formed	form	VERB
admet-247	10	35	by	by	ADP
admet-247	10	36	corneocytes	corneocyte	NOUN
admet-247	10	37	and	and	CCONJ
admet-247	10	38	an	an	DET
admet-247	10	39	intercellular	intercellular	ADJ
admet-247	10	40	lipid	lipid	NOUN
admet-247	10	41	matrix	matrix	NOUN
admet-247	10	42	)	)	PUNCT
admet-247	10	43	.	.	PUNCT
admet-247	11	1	modification	modification	NOUN
admet-247	11	2	(	(	PUNCT
admet-247	11	3	i.e.	i.e.	X
admet-247	11	4	hydration	hydration	NOUN
admet-247	11	5	,	,	PUNCT
admet-247	11	6	lipid	lipid	NOUN
admet-247	11	7	fluidization	fluidization	NOUN
admet-247	11	8	and/or	and/or	CCONJ
admet-247	11	9	disruption	disruption	NOUN
admet-247	11	10	)	)	PUNCT
admet-247	11	11	of	of	ADP
admet-247	11	12	stratum	stratum	NOUN
admet-247	11	13	corneum	corneum	NOUN
admet-247	11	14	is	be	AUX
admet-247	11	15	possible	possible	ADJ
admet-247	11	16	through	through	ADP
admet-247	11	17	:	:	PUNCT
admet-247	11	18	(	(	PUNCT
admet-247	11	19	i	i	NOUN
admet-247	11	20	)	)	PUNCT
admet-247	11	21	application	application	NOUN
admet-247	11	22	of	of	ADP
admet-247	11	23	transdermal	transdermal	ADJ
admet-247	11	24	chemical	chemical	ADJ
admet-247	11	25	permeation	permeation	NOUN
admet-247	11	26	enhancers	enhancer	NOUN
admet-247	11	27	(	(	PUNCT
admet-247	11	28	cpes	cpes	PROPN
admet-247	11	29	)	)	PUNCT
admet-247	11	30	;	;	PUNCT
admet-247	11	31	(	(	PUNCT
admet-247	11	32	ii	ii	NOUN
admet-247	11	33	)	)	PUNCT
admet-247	11	34	overall	overall	ADJ
admet-247	11	35	optimization	optimization	NOUN
admet-247	11	36	of	of	ADP
admet-247	11	37	formulation	formulation	NOUN
admet-247	11	38	using	use	VERB
admet-247	11	39	nonhydrophobic	nonhydrophobic	ADJ
admet-247	11	40	excipients	excipient	NOUN
admet-247	11	41	;	;	PUNCT
admet-247	11	42	(	(	PUNCT
admet-247	11	43	iii	iii	X
admet-247	11	44	)	)	PUNCT
admet-247	11	45	application	application	NOUN
admet-247	11	46	of	of	ADP
admet-247	11	47	physical	physical	ADJ
admet-247	11	48	enhancement	enhancement	NOUN
admet-247	11	49	techniques	technique	NOUN
admet-247	11	50	(	(	PUNCT
admet-247	11	51	electrically	electrically	ADV
admet-247	11	52	assisted	assist	VERB
admet-247	11	53	methods	method	NOUN
admet-247	11	54	)	)	PUNCT
admet-247	11	55	,	,	PUNCT
admet-247	11	56	such	such	ADJ
admet-247	11	57	as	as	ADP
admet-247	11	58	iontophoresis	iontophoresis	NOUN
admet-247	11	59	,	,	PUNCT
admet-247	11	60	electroporation	electroporation	NOUN
admet-247	11	61	,	,	PUNCT
admet-247	11	62	acoustic	acoustic	ADJ
admet-247	11	63	methods	method	NOUN
admet-247	11	64	,	,	PUNCT
admet-247	11	65	microneedles	microneedle	NOUN
admet-247	11	66	,	,	PUNCT
admet-247	11	67	etc	etc	X
admet-247	11	68	.	.	X
admet-247	11	69	)	)	PUNCT
admet-247	12	1	[	[	X
admet-247	12	2	1−3	1−3	NUM
admet-247	12	3	and	and	CCONJ
admet-247	12	4	refs	ref	NOUN
admet-247	12	5	.	.	PUNCT
admet-247	13	1	therein	therein	ADV
admet-247	13	2	]	]	PUNCT
admet-247	13	3	.	.	PUNCT
admet-247	14	1	cpes	cpes	PROPN
admet-247	14	2	can	can	AUX
admet-247	14	3	be	be	AUX
admet-247	14	4	considered	consider	VERB
admet-247	14	5	as	as	ADP
admet-247	14	6	excipients	excipient	NOUN
admet-247	14	7	specifically	specifically	ADV
admet-247	14	8	affecting	affect	VERB
admet-247	14	9	intercellular	intercellular	ADJ
admet-247	14	10	space	space	NOUN
admet-247	14	11	between	between	ADP
admet-247	14	12	corneocytes	corneocyte	NOUN
admet-247	14	13	or	or	CCONJ
admet-247	14	14	modifying	modify	VERB
admet-247	14	15	corneocytes	corneocyte	NOUN
admet-247	14	16	by	by	ADP
admet-247	14	17	hydration	hydration	NOUN
admet-247	14	18	or	or	CCONJ
admet-247	14	19	denaturation	denaturation	NOUN
admet-247	14	20	of	of	ADP
admet-247	14	21	keratin	keratin	NOUN
admet-247	14	22	.	.	PUNCT
admet-247	15	1	the	the	DET
admet-247	15	2	heterogeneity	heterogeneity	NOUN
admet-247	15	3	of	of	ADP
admet-247	15	4	molecular	molecular	ADJ
admet-247	15	5	structures	structure	NOUN
admet-247	15	6	of	of	ADP
admet-247	15	7	cpes	cpes	PROPN
admet-247	15	8	limits	limit	VERB
admet-247	15	9	simple	simple	ADJ
admet-247	15	10	explanation	explanation	NOUN
admet-247	15	11	of	of	ADP
admet-247	15	12	their	their	PRON
admet-247	15	13	action	action	NOUN
admet-247	15	14	.	.	PUNCT
admet-247	16	1	several	several	ADJ
admet-247	16	2	possible	possible	ADJ
admet-247	16	3	mechanisms	mechanism	NOUN
admet-247	16	4	of	of	ADP
admet-247	16	5	action	action	NOUN
admet-247	16	6	were	be	AUX
admet-247	16	7	hypothesized	hypothesize	VERB
admet-247	16	8	,	,	PUNCT
admet-247	16	9	but	but	CCONJ
admet-247	16	10	exact	exact	ADJ
admet-247	16	11	mechanisms	mechanism	NOUN
admet-247	16	12	have	have	AUX
admet-247	16	13	not	not	PART
admet-247	16	14	been	be	AUX
admet-247	16	15	elucidated	elucidate	VERB
admet-247	16	16	.	.	PUNCT
admet-247	17	1	it	it	PRON
admet-247	17	2	is	be	AUX
admet-247	17	3	almost	almost	ADV
admet-247	17	4	certain	certain	ADJ
admet-247	17	5	that	that	SCONJ
admet-247	17	6	cpes	cpe	NOUN
admet-247	17	7	exhibit	exhibit	VERB
admet-247	17	8	multiple	multiple	ADJ
admet-247	17	9	effects	effect	NOUN
admet-247	17	10	:	:	PUNCT
admet-247	17	11	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-247	17	12	mailto:josef.jampilek@gmail.com	mailto:josef.jampilek@gmail.com	PROPN
admet-247	17	13	cernikova	cernikova	VERB
admet-247	17	14	et	et	PROPN
admet-247	17	15	al	al	PROPN
admet-247	17	16	.	.	PROPN
admet-247	17	17	admet	admet	PROPN
admet-247	17	18	&	&	CCONJ
admet-247	17	19	dmpk	dmpk	PROPN
admet-247	17	20	3(4	3(4	NUM
admet-247	17	21	)	)	PUNCT
admet-247	17	22	(	(	PUNCT
admet-247	17	23	2015	2015	NUM
admet-247	17	24	)	)	PUNCT
admet-247	17	25	345	345	NUM
admet-247	17	26	-	-	SYM
admet-247	17	27	351	351	NUM
admet-247	17	28	346	346	NUM
admet-247	17	29	(	(	PUNCT
admet-247	17	30	i	i	NOUN
admet-247	17	31	)	)	PUNCT
admet-247	17	32	interact	interact	VERB
admet-247	17	33	with	with	ADP
admet-247	17	34	the	the	DET
admet-247	17	35	intercellular	intercellular	ADJ
admet-247	17	36	lipid	lipid	NOUN
admet-247	17	37	matrix	matrix	NOUN
admet-247	17	38	;	;	PUNCT
admet-247	17	39	(	(	PUNCT
admet-247	17	40	ii	ii	NOUN
admet-247	17	41	)	)	PUNCT
admet-247	17	42	interact	interact	VERB
admet-247	17	43	with	with	ADP
admet-247	17	44	proteins	protein	NOUN
admet-247	17	45	(	(	PUNCT
admet-247	17	46	influencing	influence	VERB
admet-247	17	47	the	the	DET
admet-247	17	48	conformation	conformation	NOUN
admet-247	17	49	of	of	ADP
admet-247	17	50	keratin	keratin	NOUN
admet-247	17	51	in	in	ADP
admet-247	17	52	corneocytes	corneocyte	NOUN
admet-247	17	53	or	or	CCONJ
admet-247	17	54	proteins	protein	NOUN
admet-247	17	55	in	in	ADP
admet-247	17	56	desmosomes	desmosome	NOUN
admet-247	17	57	)	)	PUNCT
admet-247	17	58	;	;	PUNCT
admet-247	17	59	(	(	PUNCT
admet-247	17	60	iii	iii	X
admet-247	17	61	)	)	PUNCT
admet-247	17	62	promote	promote	NOUN
admet-247	17	63	partitioning	partitioning	NOUN
admet-247	17	64	(	(	PUNCT
admet-247	17	65	influencing	influence	VERB
admet-247	17	66	the	the	DET
admet-247	17	67	stratum	stratum	NOUN
admet-247	17	68	corneum	corneum	NOUN
admet-247	17	69	nature	nature	NOUN
admet-247	17	70	leads	lead	VERB
admet-247	17	71	to	to	ADP
admet-247	17	72	raising	raise	VERB
admet-247	17	73	the	the	DET
admet-247	17	74	penetrant	penetrant	NOUN
admet-247	17	75	concentration	concentration	NOUN
admet-247	17	76	gradient	gradient	NOUN
admet-247	17	77	and	and	CCONJ
admet-247	17	78	thus	thus	ADV
admet-247	17	79	increasing	increase	VERB
admet-247	17	80	the	the	DET
admet-247	17	81	flux	flux	NOUN
admet-247	17	82	,	,	PUNCT
admet-247	17	83	i.e.	i.e.	X
admet-247	17	84	increasing	increase	VERB
admet-247	17	85	the	the	DET
admet-247	17	86	concentration	concentration	NOUN
admet-247	17	87	of	of	ADP
admet-247	17	88	the	the	DET
admet-247	17	89	drug	drug	NOUN
admet-247	17	90	in	in	ADP
admet-247	17	91	the	the	DET
admet-247	17	92	skin	skin	NOUN
admet-247	17	93	)	)	PUNCT
admet-247	18	1	[	[	X
admet-247	18	2	1−3	1−3	NUM
admet-247	18	3	and	and	CCONJ
admet-247	18	4	refs	ref	NOUN
admet-247	18	5	.	.	PUNCT
admet-247	19	1	therein	therein	ADV
admet-247	19	2	]	]	PUNCT
admet-247	19	3	.	.	PUNCT
admet-247	20	1	alaptide	alaptide	PROPN
admet-247	20	2	,	,	PUNCT
admet-247	20	3	(	(	PUNCT
admet-247	20	4	s)-8	s)-8	NOUN
admet-247	20	5	-	-	PUNCT
admet-247	20	6	methyl-6,9	methyl-6,9	NUM
admet-247	20	7	-	-	PUNCT
admet-247	20	8	diazaspiro[4.5]decan-7,10	diazaspiro[4.5]decan-7,10	NOUN
admet-247	20	9	-	-	PUNCT
admet-247	20	10	dione	dione	NOUN
admet-247	20	11	,	,	PUNCT
admet-247	20	12	(	(	PUNCT
admet-247	20	13	figure	figure	NOUN
admet-247	20	14	1	1	NUM
admet-247	20	15	)	)	PUNCT
admet-247	20	16	is	be	AUX
admet-247	20	17	an	an	DET
admet-247	20	18	original	original	ADJ
admet-247	20	19	czech	czech	NOUN
admet-247	20	20	compound	compound	NOUN
admet-247	20	21	prepared	prepare	VERB
admet-247	20	22	by	by	ADP
admet-247	20	23	kasafirek	kasafirek	PROPN
admet-247	20	24	et	et	PROPN
admet-247	20	25	al	al	PROPN
admet-247	20	26	.	.	PROPN
admet-247	21	1	in	in	ADP
admet-247	21	2	the	the	DET
admet-247	21	3	80s	80	NOUN
admet-247	21	4	of	of	ADP
admet-247	21	5	the	the	DET
admet-247	21	6	20th	20th	ADJ
admet-247	21	7	century	century	NOUN
admet-247	21	8	[	[	X
admet-247	21	9	4	4	NUM
admet-247	21	10	]	]	PUNCT
admet-247	21	11	.	.	PUNCT
admet-247	22	1	a	a	DET
admet-247	22	2	class	class	NOUN
admet-247	22	3	of	of	ADP
admet-247	22	4	similar	similar	ADJ
admet-247	22	5	compounds	compound	NOUN
admet-247	22	6	was	be	AUX
admet-247	22	7	designed	design	VERB
admet-247	22	8	as	as	ADP
admet-247	22	9	analogues	analogue	NOUN
admet-247	22	10	of	of	ADP
admet-247	22	11	melanocyte	melanocyte	NOUN
admet-247	22	12	-	-	PUNCT
admet-247	22	13	stimulating	stimulate	VERB
admet-247	22	14	hormone	hormone	NOUN
admet-247	22	15	release	release	NOUN
admet-247	22	16	-	-	PUNCT
admet-247	22	17	inhibiting	inhibit	VERB
admet-247	22	18	factor	factor	NOUN
admet-247	22	19	(	(	PUNCT
admet-247	22	20	mif-1	mif-1	NUM
admet-247	22	21	)	)	PUNCT
admet-247	23	1	[	[	X
admet-247	23	2	5	5	NUM
admet-247	23	3	]	]	PUNCT
admet-247	23	4	,	,	PUNCT
admet-247	23	5	i.e.	i.e.	X
admet-247	23	6	they	they	PRON
admet-247	23	7	negatively	negatively	ADV
admet-247	23	8	affect	affect	VERB
admet-247	23	9	the	the	DET
admet-247	23	10	inhibition	inhibition	NOUN
admet-247	23	11	of	of	ADP
admet-247	23	12	the	the	DET
admet-247	23	13	release	release	NOUN
admet-247	23	14	of	of	ADP
admet-247	23	15	melanocyte	melanocyte	NOUN
admet-247	23	16	-	-	PUNCT
admet-247	23	17	stimulating	stimulate	VERB
admet-247	23	18	hormone	hormone	NOUN
admet-247	23	19	,	,	PUNCT
admet-247	23	20	and	and	CCONJ
admet-247	23	21	thus	thus	ADV
admet-247	23	22	increase	increase	VERB
admet-247	23	23	the	the	DET
admet-247	23	24	concentration	concentration	NOUN
admet-247	23	25	of	of	ADP
admet-247	23	26	melanocytes	melanocyte	NOUN
admet-247	23	27	in	in	ADP
admet-247	23	28	epidermis	epidermis	NOUN
admet-247	23	29	.	.	PUNCT
admet-247	24	1	in	in	ADP
admet-247	24	2	relation	relation	NOUN
admet-247	24	3	to	to	ADP
admet-247	24	4	the	the	DET
admet-247	24	5	effect	effect	NOUN
admet-247	24	6	of	of	ADP
admet-247	24	7	alaptide	alaptide	NOUN
admet-247	24	8	as	as	ADP
admet-247	24	9	a	a	DET
admet-247	24	10	potential	potential	ADJ
admet-247	24	11	cpe	cpe	NOUN
admet-247	24	12	it	it	PRON
admet-247	24	13	is	be	AUX
admet-247	24	14	important	important	ADJ
admet-247	24	15	to	to	PART
admet-247	24	16	note	note	VERB
admet-247	24	17	that	that	SCONJ
admet-247	24	18	melanocytes	melanocyte	NOUN
admet-247	24	19	significantly	significantly	ADV
admet-247	24	20	influence	influence	VERB
admet-247	24	21	the	the	DET
admet-247	24	22	creation	creation	NOUN
admet-247	24	23	and	and	CCONJ
admet-247	24	24	function	function	NOUN
admet-247	24	25	of	of	ADP
admet-247	24	26	keratinocytes	keratinocyte	NOUN
admet-247	24	27	by	by	ADP
admet-247	24	28	means	mean	NOUN
admet-247	24	29	of	of	ADP
admet-247	24	30	melanosomes	melanosome	NOUN
admet-247	24	31	[	[	X
admet-247	24	32	6−8	6−8	NUM
admet-247	24	33	]	]	PUNCT
admet-247	24	34	.	.	PUNCT
admet-247	25	1	during	during	ADP
admet-247	25	2	biological	biological	ADJ
admet-247	25	3	assays	assay	NOUN
admet-247	25	4	it	it	PRON
admet-247	25	5	was	be	AUX
admet-247	25	6	found	find	VERB
admet-247	25	7	that	that	SCONJ
admet-247	25	8	alaptide	alaptide	NOUN
admet-247	25	9	showed	show	VERB
admet-247	25	10	significant	significant	ADJ
admet-247	25	11	curative	curative	ADJ
admet-247	25	12	effect	effect	NOUN
admet-247	25	13	in	in	ADP
admet-247	25	14	different	different	ADJ
admet-247	25	15	therapeutic	therapeutic	ADJ
admet-247	25	16	areas	area	NOUN
admet-247	25	17	[	[	X
admet-247	25	18	5	5	NUM
admet-247	25	19	]	]	PUNCT
admet-247	25	20	,	,	PUNCT
admet-247	25	21	for	for	ADP
admet-247	25	22	example	example	NOUN
admet-247	25	23	,	,	PUNCT
admet-247	25	24	it	it	PRON
admet-247	25	25	reduced	reduce	VERB
admet-247	25	26	the	the	DET
admet-247	25	27	number	number	NOUN
admet-247	25	28	and	and	CCONJ
admet-247	25	29	the	the	DET
admet-247	25	30	extent	extent	NOUN
admet-247	25	31	of	of	ADP
admet-247	25	32	gastric	gastric	ADJ
admet-247	25	33	ulcers	ulcer	NOUN
admet-247	25	34	[	[	X
admet-247	25	35	9,10	9,10	NUM
admet-247	25	36	]	]	PUNCT
admet-247	25	37	,	,	PUNCT
admet-247	25	38	increased	increase	VERB
admet-247	25	39	cell	cell	NOUN
admet-247	25	40	proliferation	proliferation	NOUN
admet-247	25	41	and	and	CCONJ
admet-247	25	42	epidermal	epidermal	ADJ
admet-247	25	43	regeneration	regeneration	NOUN
admet-247	25	44	and	and	CCONJ
admet-247	25	45	significantly	significantly	ADV
admet-247	25	46	accelerated	accelerate	VERB
admet-247	25	47	regeneration	regeneration	NOUN
admet-247	25	48	(	(	PUNCT
admet-247	25	49	curing	curing	NOUN
admet-247	25	50	)	)	PUNCT
admet-247	25	51	of	of	ADP
admet-247	25	52	skin	skin	NOUN
admet-247	25	53	injuries	injury	NOUN
admet-247	25	54	[	[	X
admet-247	25	55	5,11	5,11	NOUN
admet-247	25	56	]	]	X
admet-247	25	57	.	.	PUNCT
admet-247	26	1	although	although	SCONJ
admet-247	26	2	bulk	bulk	ADJ
admet-247	26	3	alaptide	alaptide	NOUN
admet-247	26	4	is	be	AUX
admet-247	26	5	absorbed	absorb	VERB
admet-247	26	6	from	from	ADP
admet-247	26	7	the	the	DET
admet-247	26	8	gastrointestinal	gastrointestinal	ADJ
admet-247	26	9	tract	tract	NOUN
admet-247	26	10	or	or	CCONJ
admet-247	26	11	permeates	permeate	VERB
admet-247	26	12	through	through	ADP
admet-247	26	13	the	the	DET
admet-247	26	14	skin	skin	NOUN
admet-247	26	15	[	[	X
admet-247	26	16	5,12	5,12	NUM
admet-247	26	17	]	]	PUNCT
admet-247	26	18	,	,	PUNCT
admet-247	26	19	nanonized	nanonize	VERB
admet-247	26	20	alaptide	alaptide	NOUN
admet-247	26	21	(	(	PUNCT
admet-247	26	22	nala	nala	NOUN
admet-247	26	23	)	)	PUNCT
admet-247	26	24	permeates	permeate	VERB
admet-247	26	25	through	through	ADP
admet-247	26	26	the	the	DET
admet-247	26	27	skin	skin	NOUN
admet-247	26	28	insignificantly	insignificantly	ADV
admet-247	26	29	[	[	X
admet-247	26	30	12	12	NUM
admet-247	26	31	]	]	PUNCT
admet-247	26	32	.	.	PUNCT
admet-247	27	1	alaptide	alaptide	NOUN
admet-247	27	2	is	be	AUX
admet-247	27	3	not	not	PART
admet-247	27	4	metabolized	metabolize	VERB
admet-247	27	5	and	and	CCONJ
admet-247	27	6	is	be	AUX
admet-247	27	7	excreted	excrete	VERB
admet-247	27	8	mostly	mostly	ADV
admet-247	27	9	via	via	ADP
admet-247	27	10	urine	urine	NOUN
admet-247	27	11	[	[	X
admet-247	27	12	13	13	NUM
admet-247	27	13	]	]	PUNCT
admet-247	27	14	.	.	PUNCT
admet-247	28	1	alaptide	alaptide	PROPN
admet-247	28	2	demonstrated	demonstrate	VERB
admet-247	28	3	very	very	ADV
admet-247	28	4	low	low	ADJ
admet-247	28	5	acute	acute	ADJ
admet-247	28	6	toxicity	toxicity	NOUN
admet-247	28	7	;	;	PUNCT
admet-247	28	8	no	no	DET
admet-247	28	9	subchronic	subchronic	ADJ
admet-247	28	10	and	and	CCONJ
admet-247	28	11	chronic	chronic	ADJ
admet-247	28	12	toxicity	toxicity	NOUN
admet-247	28	13	,	,	PUNCT
admet-247	28	14	genotoxic	genotoxic	NOUN
admet-247	28	15	,	,	PUNCT
admet-247	28	16	teratogenic	teratogenic	ADJ
admet-247	28	17	and	and	CCONJ
admet-247	28	18	embryotoxic	embryotoxic	ADJ
admet-247	28	19	effects	effect	NOUN
admet-247	28	20	were	be	AUX
admet-247	28	21	observed	observe	VERB
admet-247	28	22	[	[	X
admet-247	28	23	5,14,15	5,14,15	NUM
admet-247	28	24	]	]	PUNCT
admet-247	28	25	.	.	PUNCT
admet-247	29	1	alaptide	alaptide	ADJ
admet-247	29	2	enantiomers	enantiomer	NOUN
admet-247	29	3	do	do	AUX
admet-247	29	4	not	not	PART
admet-247	29	5	induce	induce	VERB
admet-247	29	6	cytochrome	cytochrome	NOUN
admet-247	29	7	p450	p450	PROPN
admet-247	29	8	(	(	PUNCT
admet-247	29	9	1a1	1a1	NUM
admet-247	29	10	,	,	PUNCT
admet-247	29	11	1a2	1a2	NUM
admet-247	29	12	,	,	PUNCT
admet-247	29	13	1b1	1b1	NUM
admet-247	29	14	)	)	PUNCT
admet-247	30	1	[	[	X
admet-247	30	2	16	16	NUM
admet-247	30	3	]	]	PUNCT
admet-247	30	4	.	.	PUNCT
admet-247	31	1	indomethacin	indomethacin	PROPN
admet-247	31	2	,	,	PUNCT
admet-247	31	3	[	[	X
admet-247	31	4	1-(4	1-(4	NUM
admet-247	31	5	-	-	PUNCT
admet-247	31	6	chlorobenzoyl)-5	chlorobenzoyl)-5	PROPN
admet-247	31	7	-	-	PUNCT
admet-247	31	8	methoxy-2	methoxy-2	NUM
admet-247	31	9	-	-	PUNCT
admet-247	31	10	methyl-1h	methyl-1h	NOUN
admet-247	31	11	-	-	PUNCT
admet-247	31	12	indol-3	indol-3	NUM
admet-247	31	13	-	-	PUNCT
admet-247	31	14	yl]acetic	yl]acetic	ADJ
admet-247	31	15	acid	acid	NOUN
admet-247	31	16	,	,	PUNCT
admet-247	31	17	(	(	PUNCT
admet-247	31	18	figure	figure	NOUN
admet-247	31	19	1	1	NUM
admet-247	31	20	)	)	PUNCT
admet-247	31	21	is	be	AUX
admet-247	31	22	a	a	DET
admet-247	31	23	nonsteroidal	nonsteroidal	NOUN
admet-247	31	24	anti	anti	ADJ
admet-247	31	25	-	-	ADJ
admet-247	31	26	inflammatory	inflammatory	ADJ
admet-247	31	27	drug	drug	NOUN
admet-247	31	28	(	(	PUNCT
admet-247	31	29	nsaid	nsaid	PROPN
admet-247	31	30	)	)	PUNCT
admet-247	31	31	with	with	ADP
admet-247	31	32	anti	anti	ADJ
admet-247	31	33	-	-	ADJ
admet-247	31	34	inflammatory	inflammatory	ADJ
admet-247	31	35	,	,	PUNCT
admet-247	31	36	analgesic	analgesic	ADJ
admet-247	31	37	and	and	CCONJ
admet-247	31	38	antipyretic	antipyretic	ADJ
admet-247	31	39	activity	activity	NOUN
admet-247	31	40	.	.	PUNCT
admet-247	32	1	its	its	PRON
admet-247	32	2	pharmacological	pharmacological	ADJ
admet-247	32	3	effect	effect	NOUN
admet-247	32	4	is	be	AUX
admet-247	32	5	mediated	mediate	VERB
admet-247	32	6	through	through	ADP
admet-247	32	7	inhibition	inhibition	NOUN
admet-247	32	8	of	of	ADP
admet-247	32	9	cyclooxygenase	cyclooxygenase	NOUN
admet-247	32	10	(	(	PUNCT
admet-247	32	11	cox	cox	PROPN
admet-247	32	12	)	)	PUNCT
admet-247	32	13	,	,	PUNCT
admet-247	32	14	the	the	DET
admet-247	32	15	enzyme	enzyme	NOUN
admet-247	32	16	responsible	responsible	ADJ
admet-247	32	17	for	for	ADP
admet-247	32	18	catalysing	catalyse	VERB
admet-247	32	19	the	the	DET
admet-247	32	20	rate	rate	NOUN
admet-247	32	21	-	-	PUNCT
admet-247	32	22	limiting	limit	VERB
admet-247	32	23	step	step	NOUN
admet-247	32	24	in	in	ADP
admet-247	32	25	prostaglandin	prostaglandin	ADJ
admet-247	32	26	synthesis	synthesis	NOUN
admet-247	32	27	via	via	ADP
admet-247	32	28	the	the	DET
admet-247	32	29	arachidonic	arachidonic	ADJ
admet-247	32	30	acid	acid	NOUN
admet-247	32	31	pathway	pathway	NOUN
admet-247	32	32	.	.	PUNCT
admet-247	33	1	indomethacin	indomethacin	PROPN
admet-247	33	2	inhibits	inhibit	VERB
admet-247	33	3	both	both	DET
admet-247	33	4	isoforms	isoform	NOUN
admet-247	33	5	cox-1	cox-1	PUNCT
admet-247	33	6	and	and	CCONJ
admet-247	33	7	cox-2	cox-2	NOUN
admet-247	33	8	,	,	PUNCT
admet-247	33	9	with	with	ADP
admet-247	33	10	greater	great	ADJ
admet-247	33	11	selectivity	selectivity	NOUN
admet-247	33	12	for	for	ADP
admet-247	33	13	cox-1	cox-1	X
admet-247	33	14	,	,	PUNCT
admet-247	33	15	which	which	PRON
admet-247	33	16	accounts	account	VERB
admet-247	33	17	for	for	ADP
admet-247	33	18	its	its	PRON
admet-247	33	19	increased	increase	VERB
admet-247	33	20	adverse	adverse	ADJ
admet-247	33	21	gastric	gastric	ADJ
admet-247	33	22	effects	effect	NOUN
admet-247	33	23	relative	relative	ADJ
admet-247	33	24	to	to	ADP
admet-247	33	25	other	other	ADJ
admet-247	33	26	nsaids	nsaid	NOUN
admet-247	33	27	.	.	PUNCT
admet-247	33	28	cox-1	cox-1	PUNCT
admet-247	33	29	is	be	AUX
admet-247	33	30	required	require	VERB
admet-247	33	31	for	for	ADP
admet-247	33	32	maintaining	maintain	VERB
admet-247	33	33	the	the	DET
admet-247	33	34	protective	protective	ADJ
admet-247	33	35	gastric	gastric	ADJ
admet-247	33	36	mucosal	mucosal	NOUN
admet-247	33	37	layer	layer	NOUN
admet-247	33	38	.	.	PUNCT
admet-247	34	1	the	the	DET
admet-247	34	2	analgesic	analgesic	ADJ
admet-247	34	3	,	,	PUNCT
admet-247	34	4	antipyretic	antipyretic	ADJ
admet-247	34	5	and	and	CCONJ
admet-247	34	6	anti	anti	ADJ
admet-247	34	7	-	-	ADJ
admet-247	34	8	inflammatory	inflammatory	ADJ
admet-247	34	9	effects	effect	NOUN
admet-247	34	10	of	of	ADP
admet-247	34	11	indomethacin	indomethacin	NOUN
admet-247	34	12	occur	occur	VERB
admet-247	34	13	as	as	ADP
admet-247	34	14	a	a	DET
admet-247	34	15	result	result	NOUN
admet-247	34	16	of	of	ADP
admet-247	34	17	decreased	decrease	VERB
admet-247	34	18	prostaglandin	prostaglandin	NOUN
admet-247	34	19	synthesis	synthesis	NOUN
admet-247	34	20	.	.	PUNCT
admet-247	35	1	its	its	PRON
admet-247	35	2	antipyretic	antipyretic	ADJ
admet-247	35	3	effects	effect	NOUN
admet-247	35	4	may	may	AUX
admet-247	35	5	be	be	AUX
admet-247	35	6	due	due	ADJ
admet-247	35	7	to	to	ADP
admet-247	35	8	the	the	DET
admet-247	35	9	action	action	NOUN
admet-247	35	10	on	on	ADP
admet-247	35	11	the	the	DET
admet-247	35	12	hypothalamus	hypothalamus	PROPN
admet-247	35	13	,	,	PUNCT
admet-247	35	14	resulting	result	VERB
admet-247	35	15	in	in	ADP
admet-247	35	16	an	an	DET
admet-247	35	17	increased	increase	VERB
admet-247	35	18	peripheral	peripheral	ADJ
admet-247	35	19	blood	blood	NOUN
admet-247	35	20	flow	flow	NOUN
admet-247	35	21	,	,	PUNCT
admet-247	35	22	vasodilation	vasodilation	NOUN
admet-247	35	23	and	and	CCONJ
admet-247	35	24	subsequent	subsequent	ADJ
admet-247	35	25	heat	heat	NOUN
admet-247	35	26	dissipation	dissipation	NOUN
admet-247	35	27	.	.	PUNCT
admet-247	36	1	indomethacin	indomethacin	PROPN
admet-247	36	2	is	be	AUX
admet-247	36	3	commonly	commonly	ADV
admet-247	36	4	commercially	commercially	ADV
admet-247	36	5	available	available	ADJ
admet-247	36	6	in	in	ADP
admet-247	36	7	oral	oral	ADJ
admet-247	36	8	,	,	PUNCT
admet-247	36	9	rectal	rectal	ADJ
admet-247	36	10	and	and	CCONJ
admet-247	36	11	topical	topical	ADJ
admet-247	36	12	formulations	formulation	NOUN
admet-247	36	13	[	[	X
admet-247	36	14	17	17	NUM
admet-247	36	15	]	]	PUNCT
admet-247	36	16	.	.	PUNCT
admet-247	37	1	this	this	DET
admet-247	37	2	follow	follow	NOUN
admet-247	37	3	-	-	PUNCT
admet-247	37	4	up	up	ADP
admet-247	37	5	paper	paper	NOUN
admet-247	37	6	to	to	ADP
admet-247	37	7	the	the	DET
admet-247	37	8	previous	previous	ADJ
admet-247	37	9	contributions	contribution	NOUN
admet-247	37	10	[	[	X
admet-247	37	11	18−22	18−22	X
admet-247	37	12	]	]	PUNCT
admet-247	37	13	is	be	AUX
admet-247	37	14	aimed	aim	VERB
admet-247	37	15	at	at	ADP
admet-247	37	16	the	the	DET
admet-247	37	17	investigation	investigation	NOUN
admet-247	37	18	of	of	ADP
admet-247	37	19	the	the	DET
admet-247	37	20	effect	effect	NOUN
admet-247	37	21	of	of	ADP
admet-247	37	22	nanonized	nanonized	ADJ
admet-247	37	23	alaptide	alaptide	NOUN
admet-247	37	24	as	as	ADP
admet-247	37	25	a	a	DET
admet-247	37	26	potential	potential	ADJ
admet-247	37	27	cpe	cpe	NOUN
admet-247	37	28	on	on	ADP
admet-247	37	29	the	the	DET
admet-247	37	30	permeation	permeation	NOUN
admet-247	37	31	of	of	ADP
admet-247	37	32	indomethacin	indomethacin	ADJ
admet-247	37	33	substance	substance	NOUN
admet-247	37	34	through	through	ADP
admet-247	37	35	the	the	DET
admet-247	37	36	skin	skin	NOUN
admet-247	37	37	.	.	PUNCT
admet-247	38	1	figure	figure	NOUN
admet-247	38	2	1	1	NUM
admet-247	38	3	.	.	PUNCT
admet-247	38	4	structures	structure	NOUN
admet-247	38	5	of	of	ADP
admet-247	38	6	(	(	PUNCT
admet-247	38	7	s)-alaptide	s)-alaptide	PUNCT
admet-247	38	8	and	and	CCONJ
admet-247	38	9	indomethacin	indomethacin	NOUN
admet-247	38	10	.	.	PUNCT
admet-247	39	1	experimental	experimental	ADJ
admet-247	39	2	preparation	preparation	NOUN
admet-247	39	3	of	of	ADP
admet-247	39	4	nanonized	nanonized	ADJ
admet-247	39	5	alaptide	alaptide	ADJ
admet-247	39	6	alaptide	alaptide	NOUN
admet-247	39	7	was	be	AUX
admet-247	39	8	synthesized	synthesize	VERB
admet-247	39	9	by	by	ADP
admet-247	39	10	the	the	DET
admet-247	39	11	standard	standard	ADJ
admet-247	39	12	process	process	NOUN
admet-247	39	13	[	[	X
admet-247	39	14	23	23	NUM
admet-247	39	15	]	]	PUNCT
admet-247	39	16	.	.	PUNCT
admet-247	40	1	all	all	DET
admet-247	40	2	reagents	reagent	NOUN
admet-247	40	3	were	be	AUX
admet-247	40	4	purchased	purchase	VERB
admet-247	40	5	from	from	ADP
admet-247	40	6	aldrich	aldrich	PROPN
admet-247	40	7	and	and	CCONJ
admet-247	40	8	merck	merck	PROPN
admet-247	40	9	.	.	PUNCT
admet-247	41	1	the	the	DET
admet-247	41	2	suspension	suspension	NOUN
admet-247	41	3	of	of	ADP
admet-247	41	4	alaptide	alaptide	NOUN
admet-247	41	5	(	(	PUNCT
admet-247	41	6	30	30	NUM
admet-247	41	7	g	g	NOUN
admet-247	41	8	)	)	PUNCT
admet-247	41	9	,	,	PUNCT
admet-247	41	10	polyvinylpyrrolidone	polyvinylpyrrolidone	NOUN
admet-247	41	11	(	(	PUNCT
admet-247	41	12	30	30	NUM
admet-247	41	13	g	g	NOUN
admet-247	41	14	)	)	PUNCT
admet-247	41	15	and	and	CCONJ
admet-247	41	16	purified	purified	ADJ
admet-247	41	17	water	water	NOUN
admet-247	41	18	(	(	PUNCT
admet-247	41	19	240	240	NUM
admet-247	41	20	ml	ml	NOUN
admet-247	41	21	,	,	PUNCT
admet-247	41	22	during	during	ADP
admet-247	41	23	admet	admet	PROPN
admet-247	41	24	&	&	CCONJ
admet-247	41	25	dmpk	dmpk	PROPN
admet-247	41	26	3(4	3(4	NUM
admet-247	41	27	)	)	PUNCT
admet-247	41	28	(	(	PUNCT
admet-247	41	29	2015	2015	NUM
admet-247	41	30	)	)	PUNCT
admet-247	41	31	345	345	NUM
admet-247	41	32	-	-	SYM
admet-247	41	33	351	351	NUM
admet-247	41	34	skin	skin	NOUN
admet-247	41	35	permeation	permeation	NOUN
admet-247	41	36	of	of	ADP
admet-247	41	37	indomethacin	indomethacin	PROPN
admet-247	41	38	doi	doi	NOUN
admet-247	41	39	:	:	PUNCT
admet-247	41	40	10.5599	10.5599	NUM
admet-247	41	41	/	/	SYM
admet-247	41	42	admet.3.4.247	admet.3.4.247	NOUN
admet-247	41	43	347	347	NUM
admet-247	41	44	milling	milling	NOUN
admet-247	41	45	was	be	AUX
admet-247	41	46	diluted	dilute	VERB
admet-247	41	47	by	by	ADP
admet-247	41	48	addition	addition	NOUN
admet-247	41	49	of	of	ADP
admet-247	41	50	additional	additional	ADJ
admet-247	41	51	150	150	NUM
admet-247	41	52	ml	ml	NOUN
admet-247	41	53	)	)	PUNCT
admet-247	41	54	was	be	AUX
admet-247	41	55	initially	initially	ADV
admet-247	41	56	mixed	mix	VERB
admet-247	41	57	for	for	ADP
admet-247	41	58	12	12	NUM
admet-247	41	59	h	h	NOUN
admet-247	41	60	at	at	ADP
admet-247	41	61	ambient	ambient	ADJ
admet-247	41	62	temperature	temperature	NOUN
admet-247	41	63	and	and	CCONJ
admet-247	41	64	then	then	ADV
admet-247	41	65	filtered	filter	VERB
admet-247	41	66	through	through	ADP
admet-247	41	67	a	a	DET
admet-247	41	68	mill	mill	NOUN
admet-247	41	69	sieve	sieve	NOUN
admet-247	41	70	.	.	PUNCT
admet-247	42	1	the	the	DET
admet-247	42	2	milling	milling	NOUN
admet-247	42	3	procedure	procedure	NOUN
admet-247	42	4	was	be	AUX
admet-247	42	5	performed	perform	VERB
admet-247	42	6	using	use	VERB
admet-247	42	7	a	a	DET
admet-247	42	8	nanomill	nanomill	NOUN
admet-247	42	9	netzsch	netzsch	PROPN
admet-247	42	10	(	(	PUNCT
admet-247	42	11	germany	germany	PROPN
admet-247	42	12	)	)	PUNCT
admet-247	42	13	with	with	ADP
admet-247	42	14	glass	glass	NOUN
admet-247	42	15	beads	bead	NOUN
admet-247	42	16	(	(	PUNCT
admet-247	42	17	0.3	0.3	NUM
admet-247	42	18	mm	mm	NOUN
admet-247	42	19	)	)	PUNCT
admet-247	42	20	;	;	PUNCT
admet-247	42	21	the	the	DET
admet-247	42	22	rotor	rotor	NOUN
admet-247	42	23	speed	speed	NOUN
admet-247	42	24	was	be	AUX
admet-247	42	25	986	986	NUM
admet-247	42	26	rpm	rpm	NOUN
admet-247	42	27	;	;	PUNCT
admet-247	42	28	the	the	DET
admet-247	42	29	pump	pump	NOUN
admet-247	42	30	speed	speed	NOUN
admet-247	42	31	was	be	AUX
admet-247	42	32	30	30	NUM
admet-247	42	33	rpm	rpm	NOUN
admet-247	42	34	;	;	PUNCT
admet-247	42	35	the	the	DET
admet-247	42	36	temperature	temperature	NOUN
admet-247	42	37	in	in	ADP
admet-247	42	38	the	the	DET
admet-247	42	39	grinding	grind	VERB
admet-247	42	40	chamber	chamber	NOUN
admet-247	42	41	was	be	AUX
admet-247	42	42	within	within	ADP
admet-247	42	43	17–20	17–20	NUM
admet-247	42	44	°	°	NOUN
admet-247	42	45	c	c	NOUN
admet-247	42	46	.	.	PUNCT
admet-247	43	1	the	the	DET
admet-247	43	2	rotor	rotor	NOUN
admet-247	43	3	speed	speed	NOUN
admet-247	43	4	was	be	AUX
admet-247	43	5	increased	increase	VERB
admet-247	43	6	to	to	ADP
admet-247	43	7	1500	1500	NUM
admet-247	43	8	rpm	rpm	NOUN
admet-247	43	9	after	after	ADP
admet-247	43	10	6	6	NUM
admet-247	43	11	h	h	NOUN
admet-247	43	12	of	of	ADP
admet-247	43	13	milling	milling	NOUN
admet-247	43	14	.	.	PUNCT
admet-247	44	1	the	the	DET
admet-247	44	2	total	total	ADJ
admet-247	44	3	time	time	NOUN
admet-247	44	4	of	of	ADP
admet-247	44	5	milling	milling	NOUN
admet-247	44	6	was	be	AUX
admet-247	44	7	57.5	57.5	NUM
admet-247	44	8	h.	h.	NOUN
admet-247	44	9	the	the	DET
admet-247	44	10	content	content	NOUN
admet-247	44	11	of	of	ADP
admet-247	44	12	alaptide	alaptide	NOUN
admet-247	44	13	in	in	ADP
admet-247	44	14	the	the	DET
admet-247	44	15	suspension	suspension	NOUN
admet-247	44	16	was	be	AUX
admet-247	44	17	38.76	38.76	NUM
admet-247	44	18	g	g	NOUN
admet-247	44	19	/	/	SYM
admet-247	44	20	l	l	NOUN
admet-247	44	21	(	(	PUNCT
admet-247	44	22	determined	determine	VERB
admet-247	44	23	by	by	ADP
admet-247	44	24	rp	rp	NOUN
admet-247	44	25	-	-	PUNCT
admet-247	44	26	hplc	hplc	NOUN
admet-247	44	27	[	[	X
admet-247	44	28	24	24	NUM
admet-247	44	29	]	]	PUNCT
admet-247	44	30	)	)	PUNCT
admet-247	44	31	.	.	PUNCT
admet-247	45	1	the	the	DET
admet-247	45	2	particle	particle	NOUN
admet-247	45	3	size	size	NOUN
admet-247	45	4	x90	x90	PROPN
admet-247	45	5	of	of	ADP
admet-247	45	6	the	the	DET
admet-247	45	7	prepared	prepare	VERB
admet-247	45	8	nanonized	nanonize	VERB
admet-247	45	9	alaptide	alaptide	NOUN
admet-247	45	10	measured	measure	VERB
admet-247	45	11	by	by	ADP
admet-247	45	12	sympatec	sympatec	NOUN
admet-247	45	13	nanophox	nanophox	ADP
admet-247	45	14	0138	0138	PROPN
admet-247	45	15	p	p	PROPN
admet-247	45	16	(	(	PUNCT
admet-247	45	17	germany	germany	PROPN
admet-247	45	18	)	)	PUNCT
admet-247	45	19	was	be	AUX
admet-247	45	20	770	770	NUM
admet-247	45	21	nm	nm	NOUN
admet-247	45	22	.	.	PUNCT
admet-247	46	1	in	in	ADP
admet-247	46	2	vitro	vitro	X
admet-247	46	3	transdermal	transdermal	ADJ
admet-247	46	4	permeation	permeation	NOUN
admet-247	46	5	experiments	experiment	NOUN
admet-247	46	6	skin	skin	NOUN
admet-247	46	7	samples	sample	NOUN
admet-247	46	8	were	be	AUX
admet-247	46	9	obtained	obtain	VERB
admet-247	46	10	from	from	ADP
admet-247	46	11	porcine	porcine	NOUN
admet-247	46	12	ear	ear	NOUN
admet-247	46	13	.	.	PUNCT
admet-247	47	1	full	full	ADJ
admet-247	47	2	-	-	PUNCT
admet-247	47	3	thickness	thickness	NOUN
admet-247	47	4	pig	pig	NOUN
admet-247	47	5	ear	ear	NOUN
admet-247	47	6	skin	skin	NOUN
admet-247	47	7	was	be	AUX
admet-247	47	8	cut	cut	VERB
admet-247	47	9	in	in	ADP
admet-247	47	10	fragments	fragment	NOUN
admet-247	47	11	and	and	CCONJ
admet-247	47	12	stored	store	VERB
admet-247	47	13	at	at	ADP
admet-247	47	14	−20	−20	NOUN
admet-247	47	15	°	°	ADP
admet-247	47	16	c	c	NOUN
admet-247	47	17	until	until	ADP
admet-247	47	18	utilized	utilize	VERB
admet-247	47	19	.	.	PUNCT
admet-247	48	1	skin	skin	NOUN
admet-247	48	2	samples	sample	NOUN
admet-247	48	3	were	be	AUX
admet-247	48	4	slowly	slowly	ADV
admet-247	48	5	thawed	thaw	VERB
admet-247	48	6	(	(	PUNCT
admet-247	48	7	at	at	ADP
admet-247	48	8	4	4	NUM
admet-247	48	9	°	°	NOUN
admet-247	48	10	c	c	NOUN
admet-247	48	11	overnight	overnight	ADV
admet-247	48	12	and	and	CCONJ
admet-247	48	13	then	then	ADV
admet-247	48	14	at	at	ADP
admet-247	48	15	ambient	ambient	ADJ
admet-247	48	16	temperature	temperature	NOUN
admet-247	48	17	)	)	PUNCT
admet-247	48	18	before	before	ADP
admet-247	48	19	each	each	DET
admet-247	48	20	experiment	experiment	NOUN
admet-247	48	21	[	[	X
admet-247	48	22	25,26	25,26	NUM
admet-247	48	23	]	]	X
admet-247	48	24	.	.	PUNCT
admet-247	49	1	the	the	DET
admet-247	49	2	penetration	penetration	NOUN
admet-247	49	3	enhancing	enhance	VERB
admet-247	49	4	effect	effect	NOUN
admet-247	49	5	of	of	ADP
admet-247	49	6	nala	nala	NOUN
admet-247	49	7	was	be	AUX
admet-247	49	8	evaluated	evaluate	VERB
admet-247	49	9	in	in	ADP
admet-247	49	10	vitro	vitro	NOUN
admet-247	49	11	,	,	PUNCT
admet-247	49	12	using	use	VERB
admet-247	49	13	a	a	DET
admet-247	49	14	vertical	vertical	ADJ
admet-247	49	15	franz	franz	NOUN
admet-247	49	16	diffusion	diffusion	NOUN
admet-247	49	17	cell	cell	NOUN
admet-247	49	18	(	(	PUNCT
admet-247	49	19	ses	ses	INTJ
admet-247	49	20	–	–	PUNCT
admet-247	49	21	analytical	analytical	ADJ
admet-247	49	22	systems	system	NOUN
admet-247	49	23	,	,	PUNCT
admet-247	49	24	germany	germany	PROPN
admet-247	49	25	)	)	PUNCT
admet-247	49	26	with	with	ADP
admet-247	49	27	a	a	DET
admet-247	49	28	donor	donor	NOUN
admet-247	49	29	surface	surface	NOUN
admet-247	49	30	area	area	NOUN
admet-247	49	31	of	of	ADP
admet-247	49	32	0.6359	0.6359	NUM
admet-247	49	33	cm2	cm2	NOUN
admet-247	49	34	and	and	CCONJ
admet-247	49	35	a	a	DET
admet-247	49	36	receptor	receptor	NOUN
admet-247	49	37	volume	volume	NOUN
admet-247	49	38	of	of	ADP
admet-247	49	39	5.2	5.2	NUM
admet-247	49	40	ml	ml	NOUN
admet-247	49	41	.	.	PUNCT
admet-247	50	1	the	the	DET
admet-247	50	2	skin	skin	NOUN
admet-247	50	3	was	be	AUX
admet-247	50	4	mounted	mount	VERB
admet-247	50	5	between	between	ADP
admet-247	50	6	the	the	DET
admet-247	50	7	donor	donor	NOUN
admet-247	50	8	and	and	CCONJ
admet-247	50	9	receptor	receptor	NOUN
admet-247	50	10	compartments	compartment	NOUN
admet-247	50	11	of	of	ADP
admet-247	50	12	the	the	DET
admet-247	50	13	franz	franz	NOUN
admet-247	50	14	diffusion	diffusion	NOUN
admet-247	50	15	cell	cell	NOUN
admet-247	50	16	with	with	ADP
admet-247	50	17	the	the	DET
admet-247	50	18	epidermal	epidermal	ADJ
admet-247	50	19	side	side	NOUN
admet-247	50	20	up	up	ADP
admet-247	50	21	.	.	PUNCT
admet-247	51	1	the	the	DET
admet-247	51	2	receptor	receptor	NOUN
admet-247	51	3	compartment	compartment	NOUN
admet-247	51	4	was	be	AUX
admet-247	51	5	filled	fill	VERB
admet-247	51	6	with	with	ADP
admet-247	51	7	phosphate	phosphate	ADJ
admet-247	51	8	buffered	buffer	VERB
admet-247	51	9	saline	saline	NOUN
admet-247	51	10	(	(	PUNCT
admet-247	51	11	ph	ph	NOUN
admet-247	51	12	7.4	7.4	NUM
admet-247	51	13	)	)	PUNCT
admet-247	51	14	and	and	CCONJ
admet-247	51	15	maintained	maintain	VERB
admet-247	51	16	at	at	ADP
admet-247	51	17	34±0.5	34±0.5	NUM
admet-247	51	18	°	°	SYM
admet-247	51	19	c	c	NOUN
admet-247	51	20	[	[	X
admet-247	51	21	25,27	25,27	NUM
admet-247	51	22	]	]	PUNCT
admet-247	51	23	,	,	PUNCT
admet-247	51	24	using	use	VERB
admet-247	51	25	a	a	DET
admet-247	51	26	circulating	circulate	VERB
admet-247	51	27	water	water	NOUN
admet-247	51	28	bath	bath	NOUN
admet-247	51	29	.	.	PUNCT
admet-247	52	1	the	the	DET
admet-247	52	2	receptor	receptor	NOUN
admet-247	52	3	compartment	compartment	NOUN
admet-247	52	4	content	content	NOUN
admet-247	52	5	was	be	AUX
admet-247	52	6	continuously	continuously	ADV
admet-247	52	7	stirred	stir	VERB
admet-247	52	8	using	use	VERB
admet-247	52	9	a	a	DET
admet-247	52	10	magnetic	magnetic	ADJ
admet-247	52	11	stirring	stirring	NOUN
admet-247	52	12	bar	bar	NOUN
admet-247	52	13	.	.	PUNCT
admet-247	53	1	the	the	DET
admet-247	53	2	skin	skin	NOUN
admet-247	53	3	was	be	AUX
admet-247	53	4	kept	keep	VERB
admet-247	53	5	in	in	ADP
admet-247	53	6	contact	contact	NOUN
admet-247	53	7	with	with	ADP
admet-247	53	8	the	the	DET
admet-247	53	9	receptor	receptor	NOUN
admet-247	53	10	phase	phase	NOUN
admet-247	53	11	for	for	ADP
admet-247	53	12	0.5	0.5	NUM
admet-247	53	13	h	h	NOUN
admet-247	53	14	prior	prior	ADV
admet-247	53	15	to	to	ADP
admet-247	53	16	the	the	DET
admet-247	53	17	experiment	experiment	NOUN
admet-247	53	18	.	.	PUNCT
admet-247	54	1	indomethacin	indomethacin	PROPN
admet-247	54	2	was	be	AUX
admet-247	54	3	purchased	purchase	VERB
admet-247	54	4	from	from	ADP
admet-247	54	5	sigma	sigma	NOUN
admet-247	54	6	;	;	PUNCT
admet-247	54	7	all	all	DET
admet-247	54	8	other	other	ADJ
admet-247	54	9	reagents	reagent	NOUN
admet-247	54	10	were	be	AUX
admet-247	54	11	purchased	purchase	VERB
admet-247	54	12	from	from	ADP
admet-247	54	13	merck	merck	PROPN
admet-247	54	14	.	.	PUNCT
admet-247	55	1	the	the	DET
admet-247	55	2	donor	donor	NOUN
admet-247	55	3	samples	sample	NOUN
admet-247	55	4	were	be	AUX
admet-247	55	5	prepared	prepare	VERB
admet-247	55	6	by	by	ADP
admet-247	55	7	dissolving	dissolve	VERB
admet-247	55	8	indomethacin	indomethacin	NOUN
admet-247	55	9	(	(	PUNCT
admet-247	55	10	10	10	NUM
admet-247	55	11	mg	mg	NUM
admet-247	55	12	)	)	PUNCT
admet-247	55	13	and	and	CCONJ
admet-247	55	14	nala	nala	NOUN
admet-247	55	15	(	(	PUNCT
admet-247	55	16	1	1	NUM
admet-247	55	17	mg	mg	ADP
admet-247	55	18	of	of	ADP
admet-247	55	19	alaptide	alaptide	ADJ
admet-247	55	20	,	,	PUNCT
admet-247	55	21	i.e.	i.e.	X
admet-247	55	22	26	26	NUM
admet-247	55	23	µl	µl	NOUN
admet-247	55	24	of	of	ADP
admet-247	55	25	suspension	suspension	NOUN
admet-247	55	26	)	)	PUNCT
admet-247	55	27	in	in	ADP
admet-247	55	28	propylene	propylene	NOUN
admet-247	55	29	glycol	glycol	NOUN
admet-247	55	30	(	(	PUNCT
admet-247	55	31	0.5	0.5	NUM
admet-247	55	32	ml	ml	NOUN
admet-247	55	33	)	)	PUNCT
admet-247	55	34	.	.	PUNCT
admet-247	56	1	0.5	0.5	NUM
admet-247	56	2	ml	ml	NOUN
admet-247	56	3	of	of	ADP
admet-247	56	4	water	water	NOUN
admet-247	56	5	was	be	AUX
admet-247	56	6	added	add	VERB
admet-247	56	7	to	to	ADP
admet-247	56	8	the	the	DET
admet-247	56	9	mixture	mixture	NOUN
admet-247	56	10	.	.	PUNCT
admet-247	57	1	this	this	DET
admet-247	57	2	mixture	mixture	NOUN
admet-247	57	3	was	be	AUX
admet-247	57	4	shaken	shake	VERB
admet-247	57	5	vigorously	vigorously	ADV
admet-247	57	6	and	and	CCONJ
admet-247	57	7	then	then	ADV
admet-247	57	8	sonicated	sonicate	VERB
admet-247	57	9	for	for	ADP
admet-247	57	10	10	10	NUM
admet-247	57	11	minutes	minute	NOUN
admet-247	57	12	at	at	ADP
admet-247	57	13	40	40	NUM
admet-247	57	14	°	°	NOUN
admet-247	57	15	c	c	NOUN
admet-247	57	16	,	,	PUNCT
admet-247	57	17	then	then	ADV
admet-247	57	18	this	this	DET
admet-247	57	19	stable	stable	ADJ
admet-247	57	20	system	system	NOUN
admet-247	57	21	(	(	PUNCT
admet-247	57	22	dissolved	dissolve	VERB
admet-247	57	23	indomethacin	indomethacin	NOUN
admet-247	57	24	in	in	ADP
admet-247	57	25	enhancer	enhancer	NOUN
admet-247	57	26	emulsion	emulsion	NOUN
admet-247	57	27	)	)	PUNCT
admet-247	57	28	was	be	AUX
admet-247	57	29	applied	apply	VERB
admet-247	57	30	to	to	ADP
admet-247	57	31	the	the	DET
admet-247	57	32	skin	skin	NOUN
admet-247	57	33	surface	surface	NOUN
admet-247	57	34	and	and	CCONJ
admet-247	57	35	the	the	DET
admet-247	57	36	donor	donor	NOUN
admet-247	57	37	compartment	compartment	NOUN
admet-247	57	38	of	of	ADP
admet-247	57	39	the	the	DET
admet-247	57	40	cell	cell	NOUN
admet-247	57	41	was	be	AUX
admet-247	57	42	covered	cover	VERB
admet-247	57	43	by	by	ADP
admet-247	57	44	parafilm	parafilm	NOUN
admet-247	57	45	®	®	PROPN
admet-247	57	46	.	.	PUNCT
admet-247	58	1	the	the	DET
admet-247	58	2	control	control	NOUN
admet-247	58	3	samples	sample	NOUN
admet-247	58	4	were	be	AUX
admet-247	58	5	prepared	prepare	VERB
admet-247	58	6	in	in	ADP
admet-247	58	7	the	the	DET
admet-247	58	8	same	same	ADJ
admet-247	58	9	manner	manner	NOUN
admet-247	58	10	without	without	ADP
admet-247	58	11	nala	nala	NOUN
admet-247	58	12	.	.	PUNCT
admet-247	59	1	samples	sample	NOUN
admet-247	59	2	(	(	PUNCT
admet-247	59	3	0.5	0.5	NUM
admet-247	59	4	ml	ml	NOUN
admet-247	59	5	)	)	PUNCT
admet-247	59	6	of	of	ADP
admet-247	59	7	the	the	DET
admet-247	59	8	receptor	receptor	NOUN
admet-247	59	9	phase	phase	NOUN
admet-247	59	10	were	be	AUX
admet-247	59	11	withdrawn	withdraw	VERB
admet-247	59	12	at	at	ADP
admet-247	59	13	pre	pre	ADJ
admet-247	59	14	-	-	ADJ
admet-247	59	15	determined	determined	ADJ
admet-247	59	16	time	time	NOUN
admet-247	59	17	intervals	interval	NOUN
admet-247	59	18	(	(	PUNCT
admet-247	59	19	30	30	NUM
admet-247	59	20	,	,	PUNCT
admet-247	59	21	60	60	NUM
admet-247	59	22	,	,	PUNCT
admet-247	59	23	90	90	NUM
admet-247	59	24	,	,	PUNCT
admet-247	59	25	120	120	NUM
admet-247	59	26	,	,	PUNCT
admet-247	59	27	240	240	NUM
admet-247	59	28	,	,	PUNCT
admet-247	59	29	360	360	NUM
admet-247	59	30	,	,	PUNCT
admet-247	59	31	480	480	NUM
admet-247	59	32	,	,	PUNCT
admet-247	59	33	720	720	NUM
admet-247	59	34	and	and	CCONJ
admet-247	59	35	1440	1440	NUM
admet-247	59	36	min	min	NOUN
admet-247	59	37	)	)	PUNCT
admet-247	59	38	,	,	PUNCT
admet-247	59	39	and	and	CCONJ
admet-247	59	40	the	the	DET
admet-247	59	41	cell	cell	NOUN
admet-247	59	42	was	be	AUX
admet-247	59	43	refilled	refill	VERB
admet-247	59	44	with	with	ADP
admet-247	59	45	an	an	DET
admet-247	59	46	equivalent	equivalent	ADJ
admet-247	59	47	amount	amount	NOUN
admet-247	59	48	of	of	ADP
admet-247	59	49	fresh	fresh	ADJ
admet-247	59	50	buffer	buffer	NOUN
admet-247	59	51	solution	solution	NOUN
admet-247	59	52	.	.	PUNCT
admet-247	60	1	a	a	DET
admet-247	60	2	minimum	minimum	NOUN
admet-247	60	3	of	of	ADP
admet-247	60	4	five	five	NUM
admet-247	60	5	determinations	determination	NOUN
admet-247	60	6	was	be	AUX
admet-247	60	7	performed	perform	VERB
admet-247	60	8	using	use	VERB
admet-247	60	9	skin	skin	NOUN
admet-247	60	10	fragments	fragment	NOUN
admet-247	60	11	from	from	ADP
admet-247	60	12	a	a	DET
admet-247	60	13	minimum	minimum	NOUN
admet-247	60	14	of	of	ADP
admet-247	60	15	2	2	NUM
admet-247	60	16	animals	animal	NOUN
admet-247	60	17	for	for	ADP
admet-247	60	18	each	each	DET
admet-247	60	19	composition	composition	NOUN
admet-247	60	20	,	,	PUNCT
admet-247	60	21	and	and	CCONJ
admet-247	60	22	the	the	DET
admet-247	60	23	data	datum	NOUN
admet-247	60	24	was	be	AUX
admet-247	60	25	expressed	express	VERB
admet-247	60	26	as	as	SCONJ
admet-247	60	27	means	mean	VERB
admet-247	60	28	±	±	NUM
admet-247	60	29	sd	sd	NOUN
admet-247	60	30	.	.	PUNCT
admet-247	61	1	the	the	DET
admet-247	61	2	samples	sample	NOUN
admet-247	61	3	were	be	AUX
admet-247	61	4	immediately	immediately	ADV
admet-247	61	5	analysed	analyse	VERB
admet-247	61	6	by	by	ADP
admet-247	61	7	hplc	hplc	NOUN
admet-247	61	8	.	.	PUNCT
admet-247	62	1	analysis	analysis	NOUN
admet-247	62	2	of	of	ADP
admet-247	62	3	samples	sample	NOUN
admet-247	62	4	was	be	AUX
admet-247	62	5	performed	perform	VERB
admet-247	62	6	using	use	VERB
admet-247	62	7	an	an	DET
admet-247	62	8	agilent	agilent	PROPN
admet-247	62	9	1200	1200	NUM
admet-247	62	10	series	series	PROPN
admet-247	62	11	hplc	hplc	NOUN
admet-247	62	12	system	system	NOUN
admet-247	62	13	,	,	PUNCT
admet-247	62	14	equipped	equip	VERB
admet-247	62	15	with	with	ADP
admet-247	62	16	a	a	DET
admet-247	62	17	diode	diode	NOUN
admet-247	62	18	array	array	NOUN
admet-247	62	19	detection	detection	NOUN
admet-247	62	20	(	(	PUNCT
admet-247	62	21	dad	dad	NOUN
admet-247	62	22	)	)	PUNCT
admet-247	62	23	system	system	NOUN
admet-247	62	24	,	,	PUNCT
admet-247	62	25	a	a	DET
admet-247	62	26	quaternary	quaternary	ADJ
admet-247	62	27	model	model	NOUN
admet-247	62	28	pump	pump	NOUN
admet-247	62	29	and	and	CCONJ
admet-247	62	30	an	an	DET
admet-247	62	31	automatic	automatic	ADJ
admet-247	62	32	injector	injector	NOUN
admet-247	62	33	(	(	PUNCT
admet-247	62	34	agilent	agilent	PROPN
admet-247	62	35	technologies	technologies	PROPN
admet-247	62	36	,	,	PUNCT
admet-247	62	37	germany	germany	PROPN
admet-247	62	38	)	)	PUNCT
admet-247	62	39	.	.	PUNCT
admet-247	63	1	data	datum	NOUN
admet-247	63	2	acquisition	acquisition	NOUN
admet-247	63	3	was	be	AUX
admet-247	63	4	performed	perform	VERB
admet-247	63	5	using	use	VERB
admet-247	63	6	chemstation	chemstation	NOUN
admet-247	63	7	chromatography	chromatography	NOUN
admet-247	63	8	software	software	NOUN
admet-247	63	9	.	.	PUNCT
admet-247	64	1	a	a	DET
admet-247	64	2	gemini	gemini	NOUN
admet-247	64	3	c6	c6	NOUN
admet-247	64	4	-	-	PUNCT
admet-247	64	5	phenyl	phenyl	NOUN
admet-247	64	6	110a	110a	NOUN
admet-247	64	7	5	5	NUM
admet-247	64	8	μm	μm	NOUN
admet-247	64	9	,	,	PUNCT
admet-247	64	10	250×4.6	250×4.6	NUM
admet-247	64	11	mm	mm	NOUN
admet-247	64	12	(	(	PUNCT
admet-247	64	13	phenomenex	phenomenex	ADV
admet-247	64	14	®	®	PROPN
admet-247	64	15	,	,	PUNCT
admet-247	64	16	usa	usa	PROPN
admet-247	64	17	)	)	PUNCT
admet-247	64	18	chromatographic	chromatographic	ADJ
admet-247	64	19	column	column	NOUN
admet-247	64	20	was	be	AUX
admet-247	64	21	used	use	VERB
admet-247	64	22	.	.	PUNCT
admet-247	65	1	the	the	DET
admet-247	65	2	total	total	ADJ
admet-247	65	3	flow	flow	NOUN
admet-247	65	4	of	of	ADP
admet-247	65	5	the	the	DET
admet-247	65	6	column	column	NOUN
admet-247	65	7	was	be	AUX
admet-247	65	8	1.0	1.0	NUM
admet-247	65	9	ml	ml	NOUN
admet-247	65	10	/	/	SYM
admet-247	65	11	min	min	NOUN
admet-247	65	12	;	;	PUNCT
admet-247	65	13	injection	injection	NOUN
admet-247	65	14	was	be	AUX
admet-247	65	15	10	10	NUM
admet-247	65	16	μl	μl	ADJ
admet-247	65	17	;	;	PUNCT
admet-247	65	18	column	column	NOUN
admet-247	65	19	temperature	temperature	NOUN
admet-247	65	20	was	be	AUX
admet-247	65	21	40	40	NUM
admet-247	65	22	°	°	NOUN
admet-247	65	23	c	c	NOUN
admet-247	65	24	;	;	PUNCT
admet-247	65	25	and	and	CCONJ
admet-247	65	26	sample	sample	NOUN
admet-247	65	27	temperature	temperature	NOUN
admet-247	65	28	was	be	AUX
admet-247	65	29	20	20	NUM
admet-247	65	30	°	°	NOUN
admet-247	65	31	c	c	NOUN
admet-247	65	32	.	.	PUNCT
admet-247	66	1	the	the	DET
admet-247	66	2	detection	detection	NOUN
admet-247	66	3	wavelength	wavelength	NOUN
admet-247	66	4	of	of	ADP
admet-247	66	5	260	260	NUM
admet-247	66	6	nm	nm	NOUN
admet-247	66	7	was	be	AUX
admet-247	66	8	chosen	choose	VERB
admet-247	66	9	,	,	PUNCT
admet-247	66	10	the	the	DET
admet-247	66	11	time	time	NOUN
admet-247	66	12	of	of	ADP
admet-247	66	13	analysis	analysis	NOUN
admet-247	66	14	was	be	AUX
admet-247	66	15	5	5	NUM
admet-247	66	16	min	min	NOUN
admet-247	66	17	.	.	PUNCT
admet-247	67	1	a	a	DET
admet-247	67	2	mixture	mixture	NOUN
admet-247	67	3	of	of	ADP
admet-247	67	4	meoh	meoh	PROPN
admet-247	67	5	(	(	PUNCT
admet-247	67	6	hplc	hplc	NOUN
admet-247	67	7	grade	grade	NOUN
admet-247	67	8	,	,	PUNCT
admet-247	67	9	49.0	49.0	NUM
admet-247	67	10	%	%	NOUN
admet-247	67	11	)	)	PUNCT
admet-247	67	12	with	with	ADP
admet-247	67	13	formic	formic	PROPN
admet-247	67	14	acid	acid	PROPN
admet-247	67	15	p.a	p.a	PROPN
admet-247	67	16	.	.	PUNCT
admet-247	68	1	(	(	PUNCT
admet-247	68	2	0.2	0.2	NUM
admet-247	68	3	%	%	NOUN
admet-247	68	4	)	)	PUNCT
admet-247	68	5	,	,	PUNCT
admet-247	68	6	acetonitrile	acetonitrile	NOUN
admet-247	68	7	(	(	PUNCT
admet-247	68	8	hplc	hplc	NOUN
admet-247	68	9	grade	grade	NOUN
admet-247	68	10	,	,	PUNCT
admet-247	68	11	50.0	50.0	NUM
admet-247	68	12	%	%	NOUN
admet-247	68	13	)	)	PUNCT
admet-247	68	14	and	and	CCONJ
admet-247	68	15	h2o	h2o	PROPN
admet-247	68	16	(	(	PUNCT
admet-247	68	17	hplc	hplc	NOUN
admet-247	68	18	–	–	PUNCT
admet-247	68	19	mili	mili	NOUN
admet-247	68	20	-	-	PUNCT
admet-247	68	21	q	q	NOUN
admet-247	68	22	grade	grade	NOUN
admet-247	68	23	,	,	PUNCT
admet-247	68	24	1.0	1.0	NUM
admet-247	68	25	%	%	NOUN
admet-247	68	26	)	)	PUNCT
admet-247	68	27	was	be	AUX
admet-247	68	28	used	use	VERB
admet-247	68	29	as	as	ADP
admet-247	68	30	a	a	DET
admet-247	68	31	mobile	mobile	ADJ
admet-247	68	32	phase	phase	NOUN
admet-247	68	33	.	.	PUNCT
admet-247	69	1	the	the	DET
admet-247	69	2	retention	retention	NOUN
admet-247	69	3	time	time	NOUN
admet-247	69	4	(	(	PUNCT
admet-247	69	5	tr	tr	VERB
admet-247	69	6	)	)	PUNCT
admet-247	69	7	of	of	ADP
admet-247	69	8	indomethacin	indomethacin	NOUN
admet-247	69	9	was	be	AUX
admet-247	69	10	3.1±0.05	3.1±0.05	NUM
admet-247	69	11	min	min	NOUN
admet-247	69	12	;	;	PUNCT
admet-247	69	13	the	the	DET
admet-247	69	14	limit	limit	NOUN
admet-247	69	15	of	of	ADP
admet-247	69	16	detection	detection	NOUN
admet-247	69	17	(	(	PUNCT
admet-247	69	18	lod	lod	PROPN
admet-247	69	19	)	)	PUNCT
admet-247	69	20	was	be	AUX
admet-247	69	21	0.059	0.059	NUM
admet-247	69	22	µg	µg	NOUN
admet-247	69	23	/	/	SYM
admet-247	69	24	ml	ml	NOUN
admet-247	69	25	;	;	PUNCT
admet-247	69	26	and	and	CCONJ
admet-247	69	27	the	the	DET
admet-247	69	28	limit	limit	NOUN
admet-247	69	29	of	of	ADP
admet-247	69	30	quantification	quantification	NOUN
admet-247	69	31	(	(	PUNCT
admet-247	69	32	loq	loq	PROPN
admet-247	69	33	)	)	PUNCT
admet-247	69	34	was	be	AUX
admet-247	69	35	0.197	0.197	NUM
admet-247	69	36	µg	µg	NOUN
admet-247	69	37	/	/	SYM
admet-247	69	38	ml	ml	NOUN
admet-247	69	39	.	.	PUNCT
admet-247	70	1	as	as	ADP
admet-247	70	2	a	a	DET
admet-247	70	3	result	result	NOUN
admet-247	70	4	of	of	ADP
admet-247	70	5	the	the	DET
admet-247	70	6	sampling	sampling	NOUN
admet-247	70	7	,	,	PUNCT
admet-247	70	8	the	the	DET
admet-247	70	9	receptor	receptor	NOUN
admet-247	70	10	compartment	compartment	NOUN
admet-247	70	11	concentration	concentration	NOUN
admet-247	70	12	of	of	ADP
admet-247	70	13	alaptide	alaptide	NOUN
admet-247	70	14	was	be	AUX
admet-247	70	15	corrected	correct	VERB
admet-247	70	16	for	for	ADP
admet-247	70	17	sample	sample	NOUN
admet-247	70	18	removal	removal	NOUN
admet-247	70	19	and	and	CCONJ
admet-247	70	20	replenishment	replenishment	NOUN
admet-247	70	21	using	use	VERB
admet-247	70	22	equation	equation	NOUN
admet-247	70	23	:	:	PUNCT
admet-247	70	24	c'n	c'n	PROPN
admet-247	70	25	=	=	SYM
admet-247	70	26	cn	cn	PROPN
admet-247	70	27	(	(	PUNCT
admet-247	70	28	vt	vt	PROPN
admet-247	70	29	/	/	SYM
admet-247	70	30	vt	vt	PROPN
admet-247	70	31	-	-	PUNCT
admet-247	70	32	vs	vs	NOUN
admet-247	70	33	)	)	PUNCT
admet-247	70	34	(	(	PUNCT
admet-247	70	35	c'n-1	c'n-1	X
admet-247	70	36	/	/	SYM
admet-247	70	37	cn-1	cn-1	NUM
admet-247	70	38	)	)	PUNCT
admet-247	70	39	;	;	PUNCT
admet-247	70	40	where	where	SCONJ
admet-247	70	41	c'n	c'n	NOUN
admet-247	70	42	=	=	SYM
admet-247	70	43	corrected	correct	VERB
admet-247	70	44	drug	drug	NOUN
admet-247	70	45	concentration	concentration	NOUN
admet-247	70	46	in	in	ADP
admet-247	70	47	the	the	DET
admet-247	70	48	nth	nth	NOUN
admet-247	70	49	sample	sample	NOUN
admet-247	70	50	,	,	PUNCT
admet-247	70	51	cn	cn	PROPN
admet-247	70	52	=	=	PROPN
admet-247	70	53	measured	measure	VERB
admet-247	70	54	drug	drug	NOUN
admet-247	70	55	concentration	concentration	NOUN
admet-247	70	56	in	in	ADP
admet-247	70	57	the	the	DET
admet-247	70	58	nth	nth	NOUN
admet-247	70	59	sample	sample	NOUN
admet-247	70	60	,	,	PUNCT
admet-247	70	61	c'n-1	c'n-1	X
admet-247	70	62	=	=	PUNCT
admet-247	70	63	corrected	correct	VERB
admet-247	70	64	drug	drug	NOUN
admet-247	70	65	concentration	concentration	NOUN
admet-247	70	66	in	in	ADP
admet-247	70	67	the	the	DET
admet-247	70	68	(	(	PUNCT
admet-247	70	69	n-1)th	n-1)th	PROPN
admet-247	70	70	sample	sample	NOUN
admet-247	70	71	,	,	PUNCT
admet-247	70	72	cn-1	cn-1	PUNCT
admet-247	70	73	=	=	SYM
admet-247	70	74	measured	measure	VERB
admet-247	70	75	drug	drug	NOUN
admet-247	70	76	concentration	concentration	NOUN
admet-247	70	77	in	in	ADP
admet-247	70	78	the	the	DET
admet-247	70	79	(	(	PUNCT
admet-247	70	80	n-1)th	n-1)th	PROPN
admet-247	70	81	sample	sample	NOUN
admet-247	70	82	,	,	PUNCT
admet-247	70	83	vt	vt	NOUN
admet-247	70	84	=	=	PUNCT
admet-247	70	85	total	total	ADJ
admet-247	70	86	volume	volume	NOUN
admet-247	70	87	of	of	ADP
admet-247	70	88	receptor	receptor	NOUN
admet-247	70	89	solution	solution	NOUN
admet-247	70	90	,	,	PUNCT
admet-247	70	91	vs	vs	ADP
admet-247	70	92	=	=	NOUN
admet-247	70	93	volume	volume	NOUN
admet-247	70	94	of	of	ADP
admet-247	70	95	the	the	DET
admet-247	70	96	sample	sample	NOUN
admet-247	70	97	,	,	PUNCT
admet-247	70	98	and	and	CCONJ
admet-247	70	99	c'1	c'1	PROPN
admet-247	70	100	=	=	PROPN
admet-247	70	101	c1	c1	PROPN
admet-247	71	1	[	[	X
admet-247	71	2	28	28	NUM
admet-247	71	3	]	]	PUNCT
admet-247	71	4	.	.	PUNCT
admet-247	72	1	the	the	DET
admet-247	72	2	corrected	correct	VERB
admet-247	72	3	data	datum	NOUN
admet-247	72	4	were	be	AUX
admet-247	72	5	expressed	express	VERB
admet-247	72	6	as	as	ADP
admet-247	72	7	the	the	DET
admet-247	72	8	cumulative	cumulative	ADJ
admet-247	72	9	drug	drug	NOUN
admet-247	72	10	permeation	permeation	NOUN
admet-247	72	11	(	(	PUNCT
admet-247	72	12	qt	qt	NOUN
admet-247	72	13	)	)	PUNCT
admet-247	72	14	per	per	ADP
admet-247	72	15	unit	unit	NOUN
admet-247	72	16	of	of	ADP
admet-247	72	17	skin	skin	NOUN
admet-247	72	18	surface	surface	NOUN
admet-247	72	19	area	area	NOUN
admet-247	72	20	using	use	VERB
admet-247	72	21	equation	equation	NOUN
admet-247	72	22	:	:	PUNCT
admet-247	72	23	qt	qt	NOUN
admet-247	72	24	=	=	SYM
admet-247	72	25	c'n	c'n	PROPN
admet-247	72	26	/	/	SYM
admet-247	72	27	a	a	NOUN
admet-247	72	28	;	;	PUNCT
admet-247	72	29	cernikova	cernikova	PROPN
admet-247	72	30	et	et	PROPN
admet-247	72	31	al	al	PROPN
admet-247	72	32	.	.	PROPN
admet-247	72	33	admet	admet	PROPN
admet-247	72	34	&	&	CCONJ
admet-247	72	35	dmpk	dmpk	PROPN
admet-247	72	36	3(4	3(4	NUM
admet-247	72	37	)	)	PUNCT
admet-247	72	38	(	(	PUNCT
admet-247	72	39	2015	2015	NUM
admet-247	72	40	)	)	PUNCT
admet-247	72	41	345	345	NUM
admet-247	72	42	-	-	SYM
admet-247	72	43	351	351	NUM
admet-247	72	44	348	348	NUM
admet-247	72	45	where	where	SCONJ
admet-247	72	46	a	a	DET
admet-247	72	47	=	=	SYM
admet-247	72	48	0.6359	0.6359	NUM
admet-247	72	49	cm2	cm2	NOUN
admet-247	72	50	in	in	ADP
admet-247	72	51	our	our	PRON
admet-247	72	52	experiment	experiment	NOUN
admet-247	72	53	.	.	PUNCT
admet-247	73	1	from	from	ADP
admet-247	73	2	the	the	DET
admet-247	73	3	slope	slope	NOUN
admet-247	73	4	of	of	ADP
admet-247	73	5	the	the	DET
admet-247	73	6	linear	linear	ADJ
admet-247	73	7	portion	portion	NOUN
admet-247	73	8	of	of	ADP
admet-247	73	9	the	the	DET
admet-247	73	10	curve	curve	NOUN
admet-247	73	11	[	[	X
admet-247	73	12	29	29	NUM
admet-247	73	13	]	]	PUNCT
admet-247	73	14	of	of	ADP
admet-247	73	15	the	the	DET
admet-247	73	16	dependence	dependence	NOUN
admet-247	73	17	the	the	DET
admet-247	73	18	cumulative	cumulative	ADJ
admet-247	73	19	amount	amount	NOUN
admet-247	73	20	of	of	ADP
admet-247	73	21	drug	drug	NOUN
admet-247	73	22	per	per	ADP
admet-247	73	23	unit	unit	NOUN
admet-247	73	24	area	area	NOUN
admet-247	73	25	(	(	PUNCT
admet-247	73	26	qt	qt	X
admet-247	73	27	[	[	X
admet-247	73	28	μg	μg	X
admet-247	73	29	]	]	PUNCT
admet-247	73	30	)	)	PUNCT
admet-247	73	31	on	on	ADP
admet-247	73	32	time	time	NOUN
admet-247	73	33	(	(	PUNCT
admet-247	73	34	t	t	X
admet-247	74	1	[	[	X
admet-247	74	2	h	h	X
admet-247	74	3	]	]	X
admet-247	74	4	)	)	PUNCT
admet-247	74	5	,	,	PUNCT
admet-247	74	6	steady	steady	ADJ
admet-247	74	7	-	-	PUNCT
admet-247	74	8	state	state	NOUN
admet-247	74	9	permeation	permeation	NOUN
admet-247	74	10	flux	flux	NOUN
admet-247	74	11	(	(	PUNCT
admet-247	74	12	j	j	PROPN
admet-247	74	13	[	[	X
admet-247	74	14	μg	μg	PROPN
admet-247	74	15	/	/	SYM
admet-247	74	16	h	h	PROPN
admet-247	74	17	/	/	SYM
admet-247	74	18	cm2	cm2	NOUN
admet-247	74	19	]	]	PUNCT
admet-247	74	20	)	)	PUNCT
admet-247	74	21	was	be	AUX
admet-247	74	22	determined	determine	VERB
admet-247	74	23	.	.	PUNCT
admet-247	75	1	similarly	similarly	ADV
admet-247	75	2	,	,	PUNCT
admet-247	75	3	the	the	DET
admet-247	75	4	lag	lag	NOUN
admet-247	75	5	time	time	NOUN
admet-247	75	6	(	(	PUNCT
admet-247	75	7	tlag	tlag	NOUN
admet-247	76	1	[	[	X
admet-247	76	2	h	h	X
admet-247	76	3	]	]	X
admet-247	76	4	)	)	PUNCT
admet-247	76	5	was	be	AUX
admet-247	76	6	determined	determine	VERB
admet-247	76	7	by	by	ADP
admet-247	76	8	extrapolating	extrapolate	VERB
admet-247	76	9	the	the	DET
admet-247	76	10	linear	linear	ADJ
admet-247	76	11	portion	portion	NOUN
admet-247	76	12	of	of	ADP
admet-247	76	13	cumulative	cumulative	ADJ
admet-247	76	14	amount	amount	NOUN
admet-247	76	15	of	of	ADP
admet-247	76	16	permeation	permeation	NOUN
admet-247	76	17	per	per	ADP
admet-247	76	18	unit	unit	NOUN
admet-247	76	19	area	area	NOUN
admet-247	76	20	(	(	PUNCT
admet-247	76	21	qt	qt	NOUN
admet-247	76	22	)	)	PUNCT
admet-247	76	23	versus	versus	ADP
admet-247	76	24	time	time	NOUN
admet-247	76	25	(	(	PUNCT
admet-247	76	26	t	t	X
admet-247	76	27	[	[	X
admet-247	76	28	h	h	X
admet-247	76	29	]	]	X
admet-247	76	30	)	)	PUNCT
admet-247	76	31	curve	curve	NOUN
admet-247	76	32	to	to	ADP
admet-247	76	33	the	the	DET
admet-247	76	34	abscissa	abscissa	NOUN
admet-247	77	1	[	[	X
admet-247	77	2	30	30	NUM
admet-247	77	3	]	]	PUNCT
admet-247	77	4	.	.	PUNCT
admet-247	78	1	the	the	DET
admet-247	78	2	permeability	permeability	NOUN
admet-247	78	3	coefficient	coefficient	NOUN
admet-247	78	4	(	(	PUNCT
admet-247	78	5	kp	kp	PROPN
admet-247	78	6	[	[	X
admet-247	78	7	cm	cm	NOUN
admet-247	78	8	/	/	SYM
admet-247	78	9	h	h	NOUN
admet-247	78	10	]	]	X
admet-247	78	11	)	)	PUNCT
admet-247	78	12	can	can	AUX
admet-247	78	13	be	be	AUX
admet-247	78	14	calculated	calculate	VERB
admet-247	78	15	according	accord	VERB
admet-247	78	16	to	to	ADP
admet-247	78	17	kp	kp	PROPN
admet-247	78	18	=	=	SYM
admet-247	78	19	j	j	PROPN
admet-247	78	20	/	/	SYM
admet-247	78	21	cd	cd	PROPN
admet-247	78	22	;	;	PUNCT
admet-247	78	23	where	where	SCONJ
admet-247	78	24	cd	cd	PROPN
admet-247	78	25	=	=	PUNCT
admet-247	78	26	drug	drug	NOUN
admet-247	78	27	concentration	concentration	NOUN
admet-247	78	28	in	in	ADP
admet-247	78	29	the	the	DET
admet-247	78	30	donor	donor	NOUN
admet-247	78	31	compartment	compartment	NOUN
admet-247	78	32	.	.	PUNCT
admet-247	79	1	it	it	PRON
admet-247	79	2	is	be	AUX
admet-247	79	3	assumed	assume	VERB
admet-247	79	4	that	that	SCONJ
admet-247	79	5	under	under	ADP
admet-247	79	6	sink	sink	NOUN
admet-247	79	7	conditions	condition	NOUN
admet-247	79	8	,	,	PUNCT
admet-247	79	9	drug	drug	NOUN
admet-247	79	10	concentration	concentration	NOUN
admet-247	79	11	in	in	ADP
admet-247	79	12	the	the	DET
admet-247	79	13	receptor	receptor	NOUN
admet-247	79	14	compartment	compartment	NOUN
admet-247	79	15	is	be	AUX
admet-247	79	16	negligible	negligible	ADJ
admet-247	79	17	compared	compare	VERB
admet-247	79	18	to	to	ADP
admet-247	79	19	that	that	PRON
admet-247	79	20	in	in	ADP
admet-247	79	21	the	the	DET
admet-247	79	22	donor	donor	NOUN
admet-247	79	23	compartment	compartment	NOUN
admet-247	79	24	[	[	X
admet-247	79	25	31,32	31,32	NUM
admet-247	79	26	]	]	X
admet-247	79	27	.	.	PUNCT
admet-247	80	1	the	the	DET
admet-247	80	2	enhancement	enhancement	NOUN
admet-247	80	3	effect	effect	NOUN
admet-247	80	4	was	be	AUX
admet-247	80	5	expressed	express	VERB
admet-247	80	6	as	as	ADP
admet-247	80	7	an	an	DET
admet-247	80	8	enhancement	enhancement	NOUN
admet-247	80	9	ratio	ratio	NOUN
admet-247	80	10	(	(	PUNCT
admet-247	80	11	er	er	INTJ
admet-247	80	12	)	)	PUNCT
admet-247	80	13	that	that	PRON
admet-247	80	14	was	be	AUX
admet-247	80	15	calculated	calculate	VERB
admet-247	80	16	by	by	ADP
admet-247	80	17	the	the	DET
admet-247	80	18	formula	formula	NOUN
admet-247	80	19	er	er	INTJ
admet-247	80	20	=	=	SYM
admet-247	80	21	jss	jss	PROPN
admet-247	80	22	-	-	PUNCT
admet-247	80	23	x	x	PROPN
admet-247	80	24	/	/	SYM
admet-247	80	25	jss	jss	PROPN
admet-247	80	26	-	-	PUNCT
admet-247	80	27	k	k	PROPN
admet-247	80	28	;	;	PUNCT
admet-247	80	29	where	where	SCONJ
admet-247	80	30	jss	jss	NOUN
admet-247	80	31	-	-	PUNCT
admet-247	80	32	x	x	PROPN
admet-247	80	33	=	=	SYM
admet-247	80	34	steady	steady	ADJ
admet-247	80	35	-	-	PUNCT
admet-247	80	36	state	state	NOUN
admet-247	80	37	permeation	permeation	NOUN
admet-247	80	38	flux	flux	NOUN
admet-247	80	39	with	with	ADP
admet-247	80	40	cpe	cpe	PROPN
admet-247	80	41	,	,	PUNCT
admet-247	80	42	jss	jss	PROPN
admet-247	80	43	-	-	PUNCT
admet-247	80	44	k	k	NOUN
admet-247	80	45	=	=	PUNCT
admet-247	80	46	steady	steady	ADJ
admet-247	80	47	-	-	PUNCT
admet-247	80	48	state	state	NOUN
admet-247	80	49	permeation	permeation	NOUN
admet-247	80	50	flux	flux	NOUN
admet-247	80	51	without	without	ADP
admet-247	80	52	cpe	cpe	PROPN
admet-247	80	53	[	[	X
admet-247	80	54	33	33	NUM
admet-247	80	55	]	]	PUNCT
admet-247	80	56	.	.	PUNCT
admet-247	81	1	all	all	DET
admet-247	81	2	the	the	DET
admet-247	81	3	calculated	calculate	VERB
admet-247	81	4	data	datum	NOUN
admet-247	81	5	are	be	AUX
admet-247	81	6	listed	list	VERB
admet-247	81	7	in	in	ADP
admet-247	81	8	tables	table	NOUN
admet-247	81	9	1	1	NUM
admet-247	81	10	and	and	CCONJ
admet-247	81	11	2	2	NUM
admet-247	81	12	and	and	CCONJ
admet-247	81	13	illustrated	illustrate	VERB
admet-247	81	14	in	in	ADP
admet-247	81	15	figure	figure	NOUN
admet-247	81	16	2	2	NUM
admet-247	81	17	.	.	NOUN
admet-247	81	18	results	result	NOUN
admet-247	81	19	and	and	CCONJ
admet-247	81	20	discussion	discussion	VERB
admet-247	81	21	the	the	DET
admet-247	81	22	high	high	ADJ
admet-247	81	23	toxicity	toxicity	NOUN
admet-247	81	24	and	and	CCONJ
admet-247	81	25	the	the	DET
admet-247	81	26	frequent	frequent	ADJ
admet-247	81	27	occurrence	occurrence	NOUN
admet-247	81	28	of	of	ADP
admet-247	81	29	undesirable	undesirable	ADJ
admet-247	81	30	/	/	SYM
admet-247	81	31	side	side	NOUN
admet-247	81	32	effects	effect	NOUN
admet-247	81	33	of	of	ADP
admet-247	81	34	indomethacin	indomethacin	NOUN
admet-247	81	35	,	,	PUNCT
admet-247	81	36	on	on	ADP
admet-247	81	37	the	the	DET
admet-247	81	38	one	one	NUM
admet-247	81	39	hand	hand	NOUN
admet-247	81	40	,	,	PUNCT
admet-247	81	41	and	and	CCONJ
admet-247	81	42	significant	significant	ADJ
admet-247	81	43	curative	curative	ADJ
admet-247	81	44	action	action	NOUN
admet-247	81	45	,	,	PUNCT
admet-247	81	46	on	on	ADP
admet-247	81	47	the	the	DET
admet-247	81	48	other	other	ADJ
admet-247	81	49	hand	hand	NOUN
admet-247	81	50	,	,	PUNCT
admet-247	81	51	brought	bring	VERB
admet-247	81	52	us	we	PRON
admet-247	81	53	to	to	ADP
admet-247	81	54	an	an	DET
admet-247	81	55	idea	idea	NOUN
admet-247	81	56	to	to	PART
admet-247	81	57	formulate	formulate	VERB
admet-247	81	58	this	this	DET
admet-247	81	59	substance	substance	NOUN
admet-247	81	60	with	with	ADP
admet-247	81	61	alaptide	alaptide	NOUN
admet-247	81	62	for	for	ADP
admet-247	81	63	its	its	PRON
admet-247	81	64	skin	skin	NOUN
admet-247	81	65	permeation	permeation	NOUN
admet-247	81	66	enhancement	enhancement	NOUN
admet-247	81	67	and	and	CCONJ
admet-247	81	68	thus	thus	ADV
admet-247	81	69	prepare	prepare	VERB
admet-247	81	70	less	less	ADV
admet-247	81	71	irritable	irritable	ADJ
admet-247	81	72	therapeutic	therapeutic	ADJ
admet-247	81	73	system	system	NOUN
admet-247	81	74	.	.	PUNCT
admet-247	82	1	in	in	ADP
admet-247	82	2	vitro	vitro	X
admet-247	82	3	skin	skin	NOUN
admet-247	82	4	permeation	permeation	NOUN
admet-247	82	5	experiments	experiment	NOUN
admet-247	82	6	were	be	AUX
admet-247	82	7	performed	perform	VERB
admet-247	82	8	using	use	VERB
admet-247	82	9	static	static	ADJ
admet-247	82	10	franz	franz	NOUN
admet-247	82	11	diffusion	diffusion	NOUN
admet-247	82	12	cells	cell	NOUN
admet-247	82	13	[	[	X
admet-247	82	14	27	27	NUM
admet-247	82	15	]	]	PUNCT
admet-247	82	16	within	within	ADP
admet-247	82	17	24	24	NUM
admet-247	82	18	hours	hour	NOUN
admet-247	82	19	.	.	PUNCT
admet-247	83	1	full	full	ADJ
admet-247	83	2	-	-	PUNCT
admet-247	83	3	thickness	thickness	NOUN
admet-247	83	4	pig	pig	NOUN
admet-247	83	5	ear	ear	NOUN
admet-247	83	6	skin	skin	NOUN
admet-247	83	7	was	be	AUX
admet-247	83	8	selected	select	VERB
admet-247	83	9	for	for	ADP
admet-247	83	10	in	in	ADP
admet-247	83	11	vitro	vitro	X
admet-247	83	12	evaluation	evaluation	NOUN
admet-247	83	13	of	of	ADP
admet-247	83	14	permeation	permeation	NOUN
admet-247	83	15	.	.	PUNCT
admet-247	84	1	this	this	DET
admet-247	84	2	tissue	tissue	NOUN
admet-247	84	3	is	be	AUX
admet-247	84	4	a	a	DET
admet-247	84	5	suitable	suitable	ADJ
admet-247	84	6	in	in	ADP
admet-247	84	7	vitro	vitro	X
admet-247	84	8	model	model	NOUN
admet-247	84	9	of	of	ADP
admet-247	84	10	human	human	ADJ
admet-247	84	11	skin	skin	NOUN
admet-247	84	12	[	[	X
admet-247	84	13	34,35	34,35	NOUN
admet-247	84	14	]	]	PUNCT
admet-247	84	15	,	,	PUNCT
admet-247	84	16	because	because	SCONJ
admet-247	84	17	porcine	porcine	NOUN
admet-247	84	18	skin	skin	NOUN
admet-247	84	19	has	have	AUX
admet-247	84	20	shown	show	VERB
admet-247	84	21	to	to	PART
admet-247	84	22	be	be	AUX
admet-247	84	23	histologically	histologically	ADV
admet-247	84	24	and	and	CCONJ
admet-247	84	25	biochemically	biochemically	ADV
admet-247	84	26	similar	similar	ADJ
admet-247	84	27	to	to	ADP
admet-247	84	28	human	human	ADJ
admet-247	84	29	skin	skin	NOUN
admet-247	84	30	[	[	X
admet-247	84	31	36	36	NUM
admet-247	84	32	]	]	PUNCT
admet-247	84	33	.	.	PUNCT
admet-247	85	1	the	the	DET
admet-247	85	2	permeation	permeation	NOUN
admet-247	85	3	of	of	ADP
admet-247	85	4	indomethacin	indomethacin	NOUN
admet-247	85	5	through	through	ADP
admet-247	85	6	the	the	DET
admet-247	85	7	skin	skin	NOUN
admet-247	85	8	without	without	ADP
admet-247	85	9	and	and	CCONJ
admet-247	85	10	with	with	ADP
admet-247	85	11	nala	nala	PROPN
admet-247	85	12	was	be	AUX
admet-247	85	13	tested	test	VERB
admet-247	85	14	from	from	ADP
admet-247	85	15	the	the	DET
admet-247	85	16	donor	donor	NOUN
admet-247	85	17	vehicle	vehicle	NOUN
admet-247	85	18	of	of	ADP
admet-247	85	19	propylene	propylene	NOUN
admet-247	85	20	glycol	glycol	NOUN
admet-247	85	21	/	/	SYM
admet-247	85	22	water	water	NOUN
admet-247	85	23	(	(	PUNCT
admet-247	85	24	1:1	1:1	NUM
admet-247	85	25	)	)	PUNCT
admet-247	85	26	.	.	PUNCT
admet-247	86	1	previous	previous	ADJ
admet-247	86	2	studies	study	NOUN
admet-247	86	3	have	have	AUX
admet-247	86	4	indicated	indicate	VERB
admet-247	86	5	that	that	SCONJ
admet-247	86	6	propylene	propylene	NOUN
admet-247	86	7	glycol	glycol	NOUN
admet-247	86	8	by	by	ADP
admet-247	86	9	itself	itself	PRON
admet-247	86	10	(	(	PUNCT
admet-247	86	11	or	or	CCONJ
admet-247	86	12	a	a	DET
admet-247	86	13	propylene	propylene	NOUN
admet-247	86	14	glycol	glycol	NOUN
admet-247	86	15	/	/	SYM
admet-247	86	16	water	water	NOUN
admet-247	86	17	system	system	NOUN
admet-247	86	18	)	)	PUNCT
admet-247	86	19	does	do	AUX
admet-247	86	20	not	not	PART
admet-247	86	21	interfere	interfere	VERB
admet-247	86	22	with	with	ADP
admet-247	86	23	membranes	membrane	NOUN
admet-247	86	24	[	[	X
admet-247	86	25	37,38	37,38	NOUN
admet-247	86	26	]	]	PUNCT
admet-247	86	27	.	.	PUNCT
admet-247	87	1	table	table	NOUN
admet-247	87	2	1	1	NUM
admet-247	87	3	.	.	PUNCT
admet-247	87	4	cumulative	cumulative	ADJ
admet-247	87	5	permeated	permeate	VERB
admet-247	87	6	amounts	amount	NOUN
admet-247	87	7	qt	qt	NOUN
admet-247	87	8	per	per	ADP
admet-247	87	9	unit	unit	NOUN
admet-247	87	10	area	area	NOUN
admet-247	88	1	[	[	X
admet-247	88	2	μg	μg	PROPN
admet-247	88	3	/	/	SYM
admet-247	88	4	cm	cm	PROPN
admet-247	88	5	2	2	NUM
admet-247	88	6	]	]	PUNCT
admet-247	88	7	of	of	ADP
admet-247	88	8	indomethacin	indomethacin	PROPN
admet-247	88	9	(	(	PUNCT
admet-247	88	10	idm	idm	NOUN
admet-247	88	11	)	)	PUNCT
admet-247	88	12	from	from	ADP
admet-247	88	13	propylene	propylene	NOUN
admet-247	88	14	glycol	glycol	NOUN
admet-247	88	15	:	:	PUNCT
admet-247	88	16	water	water	NOUN
admet-247	88	17	(	(	PUNCT
admet-247	88	18	1:1	1:1	NUM
admet-247	88	19	)	)	PUNCT
admet-247	88	20	without	without	ADP
admet-247	88	21	and	and	CCONJ
admet-247	88	22	with	with	ADP
admet-247	88	23	nanonized	nanonized	ADJ
admet-247	88	24	alaptide	alaptide	NOUN
admet-247	88	25	(	(	PUNCT
admet-247	88	26	nala	nala	NOUN
admet-247	88	27	)	)	PUNCT
admet-247	88	28	as	as	SCONJ
admet-247	88	29	potential	potential	ADJ
admet-247	88	30	cpe	cpe	NOUN
admet-247	88	31	achieved	achieve	VERB
admet-247	88	32	in	in	ADP
admet-247	88	33	in	in	ADP
admet-247	88	34	vitro	vitro	X
admet-247	88	35	transdermal	transdermal	ADJ
admet-247	88	36	permeation	permeation	NOUN
admet-247	88	37	experiments	experiment	NOUN
admet-247	88	38	using	use	VERB
admet-247	88	39	franz	franz	NOUN
admet-247	88	40	diffusion	diffusion	NOUN
admet-247	88	41	cell	cell	NOUN
admet-247	88	42	.	.	PUNCT
admet-247	89	1	qt	qt	NOUN
admet-247	89	2	values	value	NOUN
admet-247	89	3	are	be	AUX
admet-247	89	4	expressed	express	VERB
admet-247	89	5	as	as	ADP
admet-247	89	6	mean	mean	NOUN
admet-247	89	7	±	±	NUM
admet-247	89	8	sd	sd	NOUN
admet-247	89	9	(	(	PUNCT
admet-247	89	10	n	n	NOUN
admet-247	89	11	=	=	SYM
admet-247	89	12	5	5	NUM
admet-247	89	13	experiments	experiment	NOUN
admet-247	89	14	)	)	PUNCT
admet-247	89	15	.	.	PUNCT
admet-247	90	1	time	time	NOUN
admet-247	91	1	[	[	X
admet-247	91	2	h	h	X
admet-247	91	3	]	]	X
admet-247	91	4	cumulative	cumulative	ADJ
admet-247	91	5	permeated	permeate	VERB
admet-247	91	6	amounts	amount	NOUN
admet-247	91	7	qt	qt	NOUN
admet-247	91	8	per	per	ADP
admet-247	91	9	unit	unit	NOUN
admet-247	91	10	area[µg	area[µg	PROPN
admet-247	91	11	/	/	SYM
admet-247	91	12	cm2	cm2	PROPN
admet-247	91	13	]	]	X
admet-247	91	14	idm	idm	NOUN
admet-247	91	15	idm+nala	idm+nala	PROPN
admet-247	91	16	0.5	0.5	NUM
admet-247	91	17	0.9±0.2	0.9±0.2	NOUN
admet-247	92	1	4.6±0.6	4.6±0.6	NUM
admet-247	92	2	1.0	1.0	NUM
admet-247	92	3	1.7±0.3	1.7±0.3	NUM
admet-247	92	4	6.2±0.5	6.2±0.5	NUM
admet-247	92	5	1.5	1.5	NUM
admet-247	92	6	2.8±1.0	2.8±1.0	NUM
admet-247	92	7	7.5±0.3	7.5±0.3	NUM
admet-247	92	8	2.0	2.0	NUM
admet-247	92	9	5.1±2.0	5.1±2.0	NUM
admet-247	92	10	9.3±0.8	9.3±0.8	NUM
admet-247	92	11	3.0	3.0	NUM
admet-247	92	12	7.6±2.2	7.6±2.2	NUM
admet-247	92	13	13.1±2.5	13.1±2.5	NUM
admet-247	92	14	4.0	4.0	NUM
admet-247	92	15	10.5±2.5	10.5±2.5	NUM
admet-247	92	16	17.0±2.9	17.0±2.9	NUM
admet-247	92	17	6.0	6.0	NUM
admet-247	92	18	15.1±3.3	15.1±3.3	NUM
admet-247	92	19	32.8±3.4	32.8±3.4	NUM
admet-247	92	20	8.0	8.0	NUM
admet-247	92	21	18.9±4.6	18.9±4.6	NUM
admet-247	92	22	65.2±3.6	65.2±3.6	NUM
admet-247	92	23	12.0	12.0	NUM
admet-247	92	24	32.0±6.2	32.0±6.2	NUM
admet-247	92	25	128.9±6.3	128.9±6.3	NOUN
admet-247	92	26	24.0	24.0	NUM
admet-247	92	27	83.2±6.5	83.2±6.5	NUM
admet-247	92	28	384.1±5.2	384.1±5.2	NUM
admet-247	92	29	the	the	DET
admet-247	92	30	values	value	NOUN
admet-247	92	31	obtained	obtain	VERB
admet-247	92	32	from	from	ADP
admet-247	92	33	the	the	DET
admet-247	92	34	permeation	permeation	NOUN
admet-247	92	35	experiments	experiment	NOUN
admet-247	92	36	were	be	AUX
admet-247	92	37	expressed	express	VERB
admet-247	92	38	as	as	ADP
admet-247	92	39	the	the	DET
admet-247	92	40	cumulative	cumulative	ADJ
admet-247	92	41	permeated	permeate	VERB
admet-247	92	42	amount	amount	NOUN
admet-247	92	43	of	of	ADP
admet-247	92	44	the	the	DET
admet-247	92	45	drug	drug	NOUN
admet-247	92	46	(	(	PUNCT
admet-247	92	47	qt	qt	X
admet-247	92	48	[	[	X
admet-247	92	49	μg	μg	X
admet-247	92	50	]	]	PUNCT
admet-247	92	51	)	)	PUNCT
admet-247	92	52	per	per	ADP
admet-247	92	53	unit	unit	NOUN
admet-247	92	54	of	of	ADP
admet-247	92	55	skin	skin	NOUN
admet-247	92	56	surface	surface	NOUN
admet-247	92	57	area	area	NOUN
admet-247	92	58	,	,	PUNCT
admet-247	92	59	see	see	VERB
admet-247	92	60	table	table	NOUN
admet-247	92	61	1	1	NUM
admet-247	92	62	.	.	PUNCT
admet-247	93	1	other	other	ADJ
admet-247	93	2	permeation	permeation	NOUN
admet-247	93	3	parameters	parameter	NOUN
admet-247	93	4	of	of	ADP
admet-247	93	5	indomethacin	indomethacin	NOUN
admet-247	93	6	without	without	ADP
admet-247	93	7	and	and	CCONJ
admet-247	93	8	with	with	ADP
admet-247	93	9	nala	nala	NOUN
admet-247	93	10	from	from	ADP
admet-247	93	11	propylene	propylene	NOUN
admet-247	93	12	glycol	glycol	NOUN
admet-247	93	13	:	:	PUNCT
admet-247	93	14	water	water	NOUN
admet-247	93	15	(	(	PUNCT
admet-247	93	16	1:1	1:1	NUM
admet-247	93	17	)	)	PUNCT
admet-247	93	18	,	,	PUNCT
admet-247	93	19	steady	steady	ADJ
admet-247	93	20	-	-	PUNCT
admet-247	93	21	state	state	NOUN
admet-247	93	22	permeation	permeation	NOUN
admet-247	93	23	fluxes	flux	NOUN
admet-247	93	24	admet	admet	PROPN
admet-247	93	25	&	&	CCONJ
admet-247	93	26	dmpk	dmpk	PROPN
admet-247	93	27	3(4	3(4	NUM
admet-247	93	28	)	)	PUNCT
admet-247	93	29	(	(	PUNCT
admet-247	93	30	2015	2015	NUM
admet-247	93	31	)	)	PUNCT
admet-247	93	32	345	345	NUM
admet-247	93	33	-	-	SYM
admet-247	93	34	351	351	NUM
admet-247	93	35	skin	skin	NOUN
admet-247	93	36	permeation	permeation	NOUN
admet-247	93	37	of	of	ADP
admet-247	93	38	indomethacin	indomethacin	PROPN
admet-247	93	39	doi	doi	NOUN
admet-247	93	40	:	:	PUNCT
admet-247	93	41	10.5599	10.5599	NUM
admet-247	93	42	/	/	SYM
admet-247	93	43	admet.3.4.247	admet.3.4.247	NOUN
admet-247	93	44	349	349	NUM
admet-247	93	45	(	(	PUNCT
admet-247	93	46	j	j	PROPN
admet-247	93	47	[	[	X
admet-247	93	48	μg	μg	PROPN
admet-247	93	49	/	/	SYM
admet-247	93	50	h	h	PROPN
admet-247	93	51	/	/	SYM
admet-247	93	52	cm2	cm2	NOUN
admet-247	93	53	]	]	X
admet-247	93	54	)	)	PUNCT
admet-247	93	55	,	,	PUNCT
admet-247	93	56	lag	lag	NOUN
admet-247	93	57	times	time	NOUN
admet-247	93	58	(	(	PUNCT
admet-247	93	59	tlag	tlag	NOUN
admet-247	94	1	[	[	X
admet-247	94	2	h	h	X
admet-247	94	3	]	]	X
admet-247	94	4	)	)	PUNCT
admet-247	94	5	,	,	PUNCT
admet-247	94	6	permeability	permeability	NOUN
admet-247	94	7	coefficients	coefficient	NOUN
admet-247	94	8	(	(	PUNCT
admet-247	94	9	kp	kp	PROPN
admet-247	95	1	[	[	X
admet-247	95	2	cm	cm	NOUN
admet-247	95	3	/	/	SYM
admet-247	95	4	h	h	NOUN
admet-247	95	5	]	]	PUNCT
admet-247	95	6	)	)	PUNCT
admet-247	96	1	and	and	CCONJ
admet-247	96	2	enhancement	enhancement	NOUN
admet-247	96	3	ratio	ratio	NOUN
admet-247	96	4	(	(	PUNCT
admet-247	96	5	er	er	INTJ
admet-247	96	6	)	)	PUNCT
admet-247	96	7	are	be	AUX
admet-247	96	8	mentioned	mention	VERB
admet-247	96	9	in	in	ADP
admet-247	96	10	table	table	NOUN
admet-247	96	11	2	2	NUM
admet-247	96	12	.	.	PUNCT
admet-247	97	1	the	the	DET
admet-247	97	2	dependences	dependence	NOUN
admet-247	97	3	of	of	ADP
admet-247	97	4	the	the	DET
admet-247	97	5	cumulative	cumulative	ADJ
admet-247	97	6	permeated	permeate	VERB
admet-247	97	7	amount	amount	NOUN
admet-247	97	8	of	of	ADP
admet-247	97	9	the	the	DET
admet-247	97	10	drug	drug	NOUN
admet-247	97	11	per	per	ADP
admet-247	97	12	unit	unit	NOUN
admet-247	97	13	of	of	ADP
admet-247	97	14	skin	skin	NOUN
admet-247	97	15	surface	surface	NOUN
admet-247	97	16	area	area	NOUN
admet-247	97	17	in	in	ADP
admet-247	97	18	time	time	NOUN
admet-247	97	19	are	be	AUX
admet-247	97	20	illustrated	illustrate	VERB
admet-247	97	21	in	in	ADP
admet-247	97	22	figure	figure	NOUN
admet-247	97	23	2	2	NUM
admet-247	97	24	that	that	PRON
admet-247	97	25	is	be	AUX
admet-247	97	26	divided	divide	VERB
admet-247	97	27	into	into	ADP
admet-247	97	28	parts	part	NOUN
admet-247	97	29	a	a	PRON
admet-247	97	30	and	and	CCONJ
admet-247	97	31	b	b	NOUN
admet-247	97	32	for	for	ADP
admet-247	97	33	better	well	ADJ
admet-247	97	34	lucidity	lucidity	NOUN
admet-247	97	35	.	.	PUNCT
admet-247	98	1	table	table	NOUN
admet-247	98	2	2	2	NUM
admet-247	98	3	.	.	PUNCT
admet-247	98	4	permeation	permeation	NOUN
admet-247	98	5	parameters	parameter	NOUN
admet-247	98	6	of	of	ADP
admet-247	98	7	indomethacin	indomethacin	PROPN
admet-247	98	8	(	(	PUNCT
admet-247	98	9	idm	idm	NOUN
admet-247	98	10	)	)	PUNCT
admet-247	98	11	without	without	ADP
admet-247	98	12	and	and	CCONJ
admet-247	98	13	with	with	ADP
admet-247	98	14	nanonized	nanonized	ADJ
admet-247	98	15	alaptide	alaptide	NOUN
admet-247	98	16	(	(	PUNCT
admet-247	98	17	nala	nala	NOUN
admet-247	98	18	)	)	PUNCT
admet-247	98	19	from	from	ADP
admet-247	98	20	propylene	propylene	NOUN
admet-247	98	21	glycol	glycol	NOUN
admet-247	98	22	:	:	PUNCT
admet-247	98	23	water	water	NOUN
admet-247	98	24	(	(	PUNCT
admet-247	98	25	1:1	1:1	NUM
admet-247	98	26	):	):	PUNCT
admet-247	98	27	steady	steady	ADJ
admet-247	98	28	-	-	PUNCT
admet-247	98	29	state	state	NOUN
admet-247	98	30	permeation	permeation	NOUN
admet-247	98	31	fluxes	flux	NOUN
admet-247	98	32	(	(	PUNCT
admet-247	98	33	j	j	NOUN
admet-247	98	34	)	)	PUNCT
admet-247	98	35	,	,	PUNCT
admet-247	98	36	corresponding	correspond	VERB
admet-247	98	37	lag	lag	PROPN
admet-247	98	38	times	time	NOUN
admet-247	98	39	(	(	PUNCT
admet-247	98	40	tlag	tlag	NOUN
admet-247	98	41	)	)	PUNCT
admet-247	98	42	,	,	PUNCT
admet-247	98	43	permeability	permeability	NOUN
admet-247	98	44	coefficients	coefficient	NOUN
admet-247	98	45	(	(	PUNCT
admet-247	98	46	kp	kp	INTJ
admet-247	98	47	)	)	PUNCT
admet-247	98	48	and	and	CCONJ
admet-247	98	49	enhancement	enhancement	NOUN
admet-247	98	50	ratio	ratio	NOUN
admet-247	98	51	(	(	PUNCT
admet-247	98	52	er	er	INTJ
admet-247	98	53	)	)	PUNCT
admet-247	98	54	.	.	PUNCT
admet-247	99	1	all	all	DET
admet-247	99	2	values	value	NOUN
admet-247	99	3	are	be	AUX
admet-247	99	4	expressed	express	VERB
admet-247	99	5	as	as	ADP
admet-247	99	6	mean	mean	NOUN
admet-247	99	7	±	±	NUM
admet-247	99	8	sd	sd	NOUN
admet-247	99	9	(	(	PUNCT
admet-247	99	10	n	n	NOUN
admet-247	99	11	=	=	SYM
admet-247	99	12	5	5	NUM
admet-247	99	13	experiments	experiment	NOUN
admet-247	99	14	)	)	PUNCT
admet-247	99	15	.	.	PUNCT
admet-247	100	1	sample	sample	PROPN
admet-247	100	2	j	j	PROPN
admet-247	101	1	[	[	X
admet-247	101	2	μg	μg	PROPN
admet-247	101	3	/	/	SYM
admet-247	101	4	cm2	cm2	NOUN
admet-247	101	5	/	/	SYM
admet-247	101	6	h	h	NOUN
admet-247	101	7	]	]	X
admet-247	101	8	tlag	tlag	NOUN
admet-247	102	1	[	[	X
admet-247	102	2	h	h	X
admet-247	102	3	]	]	X
admet-247	102	4	kp×10	kp×10	PROPN
admet-247	102	5	-	-	SYM
admet-247	102	6	3	3	NUM
admet-247	102	7	[	[	X
admet-247	102	8	cm	cm	NOUN
admet-247	102	9	/	/	SYM
admet-247	102	10	h	h	NOUN
admet-247	102	11	]	]	X
admet-247	102	12	er	er	INTJ
admet-247	102	13	idm	idm	NOUN
admet-247	102	14	2.9±0.4	2.9±0.4	NUM
admet-247	102	15	1.0±0.6	1.0±0.6	NUM
admet-247	102	16	0.3±0.05	0.3±0.05	NUM
admet-247	102	17	–	–	PUNCT
admet-247	102	18	idm+nala	idm+nala	PROPN
admet-247	102	19	16.1±1.2	16.1±1.2	NUM
admet-247	102	20	3.9±0.2	3.9±0.2	NUM
admet-247	102	21	1.6±0.1	1.6±0.1	NUM
admet-247	102	22	5.6±0.4	5.6±0.4	NUM
admet-247	102	23	figure	figure	NOUN
admet-247	102	24	2	2	NUM
admet-247	102	25	.	.	PUNCT
admet-247	103	1	in	in	ADP
admet-247	103	2	vitro	vitro	X
admet-247	103	3	profile	profile	NOUN
admet-247	103	4	of	of	ADP
admet-247	103	5	cumulative	cumulative	ADJ
admet-247	103	6	permeated	permeate	VERB
admet-247	103	7	amounts	amount	NOUN
admet-247	103	8	qt	qt	NOUN
admet-247	103	9	per	per	ADP
admet-247	103	10	unit	unit	NOUN
admet-247	103	11	area	area	NOUN
admet-247	104	1	[	[	X
admet-247	104	2	μg	μg	PROPN
admet-247	104	3	/	/	SYM
admet-247	104	4	cm	cm	PROPN
admet-247	104	5	2	2	NUM
admet-247	104	6	]	]	PUNCT
admet-247	104	7	in	in	ADP
admet-247	104	8	time	time	NOUN
admet-247	104	9	of	of	ADP
admet-247	104	10	indomethacin	indomethacin	NOUN
admet-247	104	11	(	(	PUNCT
admet-247	104	12	idm	idm	NOUN
admet-247	104	13	)	)	PUNCT
admet-247	104	14	alone	alone	ADV
admet-247	104	15	and	and	CCONJ
admet-247	104	16	after	after	ADP
admet-247	104	17	addition	addition	NOUN
admet-247	104	18	of	of	ADP
admet-247	104	19	nanonized	nanonized	ADJ
admet-247	104	20	alaptide	alaptide	NOUN
admet-247	104	21	(	(	PUNCT
admet-247	104	22	nala	nala	NOUN
admet-247	104	23	)	)	PUNCT
admet-247	104	24	in	in	ADP
admet-247	104	25	ratio	ratio	NOUN
admet-247	104	26	10:1	10:1	NUM
admet-247	104	27	(	(	PUNCT
admet-247	104	28	idm	idm	NOUN
admet-247	104	29	:	:	PUNCT
admet-247	104	30	nala	nala	PROPN
admet-247	104	31	)	)	PUNCT
admet-247	104	32	from	from	ADP
admet-247	104	33	propylene	propylene	NOUN
admet-247	104	34	glycol	glycol	NOUN
admet-247	104	35	/	/	SYM
admet-247	104	36	water	water	NOUN
admet-247	104	37	(	(	PUNCT
admet-247	104	38	1:1	1:1	NUM
admet-247	104	39	)	)	PUNCT
admet-247	104	40	system	system	NOUN
admet-247	104	41	through	through	ADP
admet-247	104	42	skin	skin	NOUN
admet-247	104	43	.	.	PUNCT
admet-247	105	1	qt	qt	NOUN
admet-247	105	2	values	value	NOUN
admet-247	105	3	are	be	AUX
admet-247	105	4	expressed	express	VERB
admet-247	105	5	as	as	ADP
admet-247	105	6	mean	mean	NOUN
admet-247	105	7	±	±	NUM
admet-247	105	8	sd	sd	NOUN
admet-247	105	9	(	(	PUNCT
admet-247	105	10	n	n	NOUN
admet-247	105	11	=	=	SYM
admet-247	105	12	5	5	NUM
admet-247	105	13	experiments	experiment	NOUN
admet-247	105	14	)	)	PUNCT
admet-247	105	15	.	.	PUNCT
admet-247	106	1	the	the	DET
admet-247	106	2	permeated	permeate	VERB
admet-247	106	3	amount	amount	NOUN
admet-247	106	4	of	of	ADP
admet-247	106	5	indomethacin	indomethacin	NOUN
admet-247	106	6	with	with	ADP
admet-247	106	7	nala	nala	PROPN
admet-247	106	8	increased	increase	VERB
admet-247	106	9	rapidly	rapidly	ADV
admet-247	106	10	already	already	ADV
admet-247	106	11	at	at	ADP
admet-247	106	12	the	the	DET
admet-247	106	13	30th	30th	ADJ
admet-247	106	14	minute	minute	NOUN
admet-247	106	15	,	,	PUNCT
admet-247	106	16	when	when	SCONJ
admet-247	106	17	it	it	PRON
admet-247	106	18	reached	reach	VERB
admet-247	106	19	approx	approx	NOUN
admet-247	106	20	.	.	PUNCT
admet-247	107	1	5	5	X
admet-247	107	2	-	-	ADJ
admet-247	107	3	fold	fold	VERB
admet-247	107	4	higher	high	ADJ
admet-247	107	5	values	value	NOUN
admet-247	107	6	than	than	ADP
admet-247	107	7	formulation	formulation	NOUN
admet-247	107	8	without	without	ADP
admet-247	107	9	nala	nala	NOUN
admet-247	107	10	,	,	PUNCT
admet-247	107	11	see	see	VERB
admet-247	107	12	table	table	NOUN
admet-247	107	13	1	1	NUM
admet-247	107	14	.	.	PUNCT
admet-247	107	15	similarly	similarly	ADV
admet-247	107	16	sharp	sharp	ADJ
admet-247	107	17	enhancement	enhancement	NOUN
admet-247	107	18	of	of	ADP
admet-247	107	19	transdermal	transdermal	ADJ
admet-247	107	20	permeation	permeation	NOUN
admet-247	107	21	was	be	AUX
admet-247	107	22	found	find	VERB
admet-247	107	23	,	,	PUNCT
admet-247	107	24	e.g.	e.g.	ADV
admet-247	107	25	,	,	PUNCT
admet-247	107	26	for	for	ADP
admet-247	107	27	permeation	permeation	NOUN
admet-247	107	28	of	of	ADP
admet-247	107	29	other	other	ADJ
admet-247	107	30	nsaids	nsaid	NOUN
admet-247	107	31	or	or	CCONJ
admet-247	107	32	antipyretics	antipyretic	NOUN
admet-247	107	33	,	,	PUNCT
admet-247	107	34	such	such	ADJ
admet-247	107	35	as	as	ADP
admet-247	107	36	ibuprofen	ibuprofen	NOUN
admet-247	107	37	,	,	PUNCT
admet-247	107	38	nimesulide	nimesulide	NOUN
admet-247	107	39	,	,	PUNCT
admet-247	107	40	acetylsalicylic	acetylsalicylic	NOUN
admet-247	107	41	acid	acid	NOUN
admet-247	107	42	or	or	CCONJ
admet-247	107	43	paracetamol	paracetamol	NOUN
admet-247	107	44	[	[	X
admet-247	107	45	18,19,21	18,19,21	NUM
admet-247	107	46	]	]	X
admet-247	107	47	.	.	PUNCT
admet-247	108	1	it	it	PRON
admet-247	108	2	can	can	AUX
admet-247	108	3	be	be	AUX
admet-247	108	4	stated	state	VERB
admet-247	108	5	that	that	SCONJ
admet-247	108	6	indomethacin	indomethacin	VERB
admet-247	108	7	without	without	ADP
admet-247	108	8	nala	nala	PROPN
admet-247	108	9	permeated	permeate	VERB
admet-247	108	10	moderately	moderately	ADV
admet-247	108	11	in	in	ADP
admet-247	108	12	comparison	comparison	NOUN
admet-247	108	13	with	with	ADP
admet-247	108	14	indomethacin	indomethacin	NOUN
admet-247	108	15	with	with	ADP
admet-247	108	16	added	add	VERB
admet-247	108	17	nala	nala	NOUN
admet-247	108	18	;	;	PUNCT
admet-247	108	19	in	in	ADP
admet-247	108	20	the	the	DET
admet-247	108	21	whole	whole	ADJ
admet-247	108	22	investigated	investigate	VERB
admet-247	108	23	time	time	NOUN
admet-247	108	24	range	range	NOUN
admet-247	108	25	in	in	ADP
admet-247	108	26	every	every	DET
admet-247	108	27	time	time	NOUN
admet-247	108	28	the	the	DET
admet-247	108	29	corresponding	correspond	VERB
admet-247	108	30	qt	qt	NOUN
admet-247	108	31	values	value	NOUN
admet-247	108	32	related	relate	VERB
admet-247	108	33	to	to	ADP
admet-247	108	34	the	the	DET
admet-247	108	35	system	system	NOUN
admet-247	108	36	without	without	ADP
admet-247	108	37	and	and	CCONJ
admet-247	108	38	with	with	ADP
admet-247	108	39	nala	nala	NOUN
admet-247	108	40	were	be	AUX
admet-247	108	41	statistically	statistically	ADV
admet-247	108	42	different	different	ADJ
admet-247	108	43	from	from	ADP
admet-247	108	44	each	each	DET
admet-247	108	45	other	other	ADJ
admet-247	108	46	,	,	PUNCT
admet-247	108	47	see	see	VERB
admet-247	108	48	figures	figure	NOUN
admet-247	108	49	2a	2a	NUM
admet-247	108	50	and	and	CCONJ
admet-247	108	51	2b	2b	NOUN
admet-247	108	52	.	.	PUNCT
admet-247	109	1	the	the	DET
admet-247	109	2	effectivity	effectivity	NOUN
admet-247	109	3	of	of	ADP
admet-247	109	4	alaptide	alaptide	NOUN
admet-247	109	5	as	as	ADP
admet-247	109	6	a	a	DET
admet-247	109	7	potential	potential	ADJ
admet-247	109	8	cpe	cpe	NOUN
admet-247	109	9	can	can	AUX
admet-247	109	10	also	also	ADV
admet-247	109	11	be	be	AUX
admet-247	109	12	confirmed	confirm	VERB
admet-247	109	13	by	by	ADP
admet-247	109	14	parameters	parameter	NOUN
admet-247	109	15	mentioned	mention	VERB
admet-247	109	16	in	in	ADP
admet-247	109	17	table	table	NOUN
admet-247	109	18	2	2	NUM
admet-247	109	19	,	,	PUNCT
admet-247	109	20	since	since	SCONJ
admet-247	109	21	significant	significant	ADJ
admet-247	109	22	increases	increase	NOUN
admet-247	109	23	of	of	ADP
admet-247	109	24	steady	steady	ADJ
admet-247	109	25	-	-	PUNCT
admet-247	109	26	state	state	NOUN
admet-247	109	27	permeation	permeation	NOUN
admet-247	109	28	flux	flux	NOUN
admet-247	109	29	and	and	CCONJ
admet-247	109	30	permeability	permeability	NOUN
admet-247	109	31	coefficient	coefficient	NOUN
admet-247	109	32	(	(	PUNCT
admet-247	109	33	approx	approx	PROPN
admet-247	109	34	.	.	PUNCT
admet-247	110	1	about	about	ADV
admet-247	110	2	5.3	5.3	NUM
admet-247	110	3	)	)	PUNCT
admet-247	110	4	were	be	AUX
admet-247	110	5	observed	observe	VERB
admet-247	110	6	.	.	PUNCT
admet-247	111	1	enhancement	enhancement	NOUN
admet-247	111	2	ratio	ratio	NOUN
admet-247	111	3	calculated	calculate	VERB
admet-247	111	4	from	from	ADP
admet-247	111	5	steady	steady	ADJ
admet-247	111	6	-	-	PUNCT
admet-247	111	7	state	state	NOUN
admet-247	111	8	permeation	permeation	NOUN
admet-247	111	9	fluxes	flux	NOUN
admet-247	111	10	is	be	AUX
admet-247	111	11	5.6	5.6	NUM
admet-247	111	12	,	,	PUNCT
admet-247	111	13	which	which	PRON
admet-247	111	14	indicates	indicate	VERB
admet-247	111	15	that	that	SCONJ
admet-247	111	16	nanonized	nanonized	ADJ
admet-247	111	17	alaptide	alaptide	ADJ
admet-247	111	18	enhanced	enhance	VERB
admet-247	111	19	permeation	permeation	NOUN
admet-247	111	20	of	of	ADP
admet-247	111	21	compounds	compound	NOUN
admet-247	111	22	through	through	ADP
admet-247	111	23	the	the	DET
admet-247	111	24	skin	skin	NOUN
admet-247	111	25	.	.	PUNCT
admet-247	112	1	on	on	ADP
admet-247	112	2	the	the	DET
admet-247	112	3	other	other	ADJ
admet-247	112	4	hand	hand	NOUN
admet-247	112	5	,	,	PUNCT
admet-247	112	6	an	an	DET
admet-247	112	7	absolutely	absolutely	ADV
admet-247	112	8	different	different	ADJ
admet-247	112	9	effect	effect	NOUN
admet-247	112	10	was	be	AUX
admet-247	112	11	observed	observe	VERB
admet-247	112	12	for	for	ADP
admet-247	112	13	the	the	DET
admet-247	112	14	combination	combination	NOUN
admet-247	112	15	of	of	ADP
admet-247	112	16	bactroban	bactroban	NOUN
admet-247	112	17	®	®	NOUN
admet-247	112	18	leciva	leciva	NOUN
admet-247	112	19	with	with	ADP
admet-247	112	20	nala	nala	NOUN
admet-247	112	21	when	when	SCONJ
admet-247	112	22	a	a	DET
admet-247	112	23	significant	significant	ADJ
admet-247	112	24	decrease	decrease	NOUN
admet-247	112	25	of	of	ADP
admet-247	112	26	permeation	permeation	NOUN
admet-247	112	27	(	(	PUNCT
admet-247	112	28	in	in	ADP
admet-247	112	29	fact	fact	NOUN
admet-247	112	30	,	,	PUNCT
admet-247	112	31	blockade	blockade	NOUN
admet-247	112	32	of	of	ADP
admet-247	112	33	permeation	permeation	NOUN
admet-247	112	34	)	)	PUNCT
admet-247	112	35	of	of	ADP
admet-247	112	36	mupirocin	mupirocin	NOUN
admet-247	112	37	from	from	ADP
admet-247	112	38	ointment	ointment	NOUN
admet-247	112	39	through	through	ADP
admet-247	112	40	the	the	DET
admet-247	112	41	skin	skin	NOUN
admet-247	112	42	occurred	occur	VERB
admet-247	112	43	during	during	ADP
admet-247	112	44	the	the	DET
admet-247	112	45	experiment	experiment	NOUN
admet-247	112	46	,	,	PUNCT
admet-247	112	47	indicating	indicate	VERB
admet-247	112	48	that	that	SCONJ
admet-247	112	49	mupirocin	mupirocin	PROPN
admet-247	112	50	can	can	AUX
admet-247	112	51	act	act	VERB
admet-247	112	52	curatively	curatively	ADV
admet-247	112	53	only	only	ADV
admet-247	112	54	on	on	ADP
admet-247	112	55	the	the	DET
admet-247	112	56	surface	surface	NOUN
admet-247	112	57	of	of	ADP
admet-247	112	58	the	the	DET
admet-247	112	59	skin	skin	NOUN
admet-247	112	60	[	[	X
admet-247	112	61	20	20	NUM
admet-247	112	62	]	]	PUNCT
admet-247	112	63	.	.	PUNCT
admet-247	113	1	based	base	VERB
admet-247	113	2	on	on	ADP
admet-247	113	3	the	the	DET
admet-247	113	4	presented	present	VERB
admet-247	113	5	results	result	NOUN
admet-247	113	6	,	,	PUNCT
admet-247	113	7	it	it	PRON
admet-247	113	8	can	can	AUX
admet-247	113	9	be	be	AUX
admet-247	113	10	assumed	assume	VERB
admet-247	113	11	that	that	SCONJ
admet-247	113	12	the	the	DET
admet-247	113	13	contribution	contribution	NOUN
admet-247	113	14	of	of	ADP
admet-247	113	15	nala	nala	NOUN
admet-247	113	16	to	to	ADP
admet-247	113	17	the	the	DET
admet-247	113	18	enhanced	enhanced	ADJ
admet-247	113	19	permeation	permeation	NOUN
admet-247	113	20	of	of	ADP
admet-247	113	21	indomethacin	indomethacin	NOUN
admet-247	113	22	through	through	ADP
admet-247	113	23	the	the	DET
admet-247	113	24	skin	skin	NOUN
admet-247	113	25	is	be	AUX
admet-247	113	26	significant	significant	ADJ
admet-247	113	27	not	not	PART
admet-247	113	28	only	only	ADV
admet-247	113	29	immediately	immediately	ADV
admet-247	113	30	after	after	ADP
admet-247	113	31	application	application	NOUN
admet-247	113	32	but	but	CCONJ
admet-247	113	33	also	also	ADV
admet-247	113	34	for	for	ADP
admet-247	113	35	long	long	ADJ
admet-247	113	36	-	-	PUNCT
admet-247	113	37	term	term	NOUN
admet-247	113	38	application	application	NOUN
admet-247	113	39	.	.	PUNCT
admet-247	114	1	the	the	DET
admet-247	114	2	structure	structure	NOUN
admet-247	114	3	of	of	ADP
admet-247	114	4	alaptide	alaptide	NOUN
admet-247	114	5	can	can	AUX
admet-247	114	6	be	be	AUX
admet-247	114	7	classified	classify	VERB
admet-247	114	8	as	as	ADP
admet-247	114	9	a	a	DET
admet-247	114	10	hybrid	hybrid	NOUN
admet-247	114	11	between	between	ADP
admet-247	114	12	the	the	DET
admet-247	114	13	derivatives	derivative	NOUN
admet-247	114	14	of	of	ADP
admet-247	114	15	0	0	NUM
admet-247	114	16	5	5	NUM
admet-247	114	17	10	10	NUM
admet-247	114	18	15	15	NUM
admet-247	114	19	20	20	NUM
admet-247	114	20	25	25	NUM
admet-247	114	21	30	30	NUM
admet-247	114	22	35	35	NUM
admet-247	114	23	40	40	NUM
admet-247	114	24	0.0	0.0	NUM
admet-247	114	25	1.0	1.0	NUM
admet-247	114	26	2.0	2.0	NUM
admet-247	114	27	3.0	3.0	NUM
admet-247	114	28	4.0	4.0	NUM
admet-247	114	29	5.0	5.0	NUM
admet-247	114	30	6.0	6.0	NUM
admet-247	114	31	7.0	7.0	NUM
admet-247	114	32	q	q	NOUN
admet-247	114	33	t	t	PROPN
admet-247	114	34	[	[	X
admet-247	114	35			NOUN
admet-247	114	36	g	g	NOUN
admet-247	114	37	/c	/c	PUNCT
admet-247	115	1	m	m	VERB
admet-247	115	2	2	2	NUM
admet-247	115	3	]	]	PUNCT
admet-247	115	4	time	time	NOUN
admet-247	116	1	[	[	X
admet-247	116	2	h	h	X
admet-247	116	3	]	]	X
admet-247	116	4	idm	idm	NOUN
admet-247	116	5	idm+nala	idm+nala	PROPN
admet-247	116	6	a	a	DET
admet-247	116	7	0	0	NUM
admet-247	116	8	50	50	NUM
admet-247	116	9	100	100	NUM
admet-247	116	10	150	150	NUM
admet-247	116	11	200	200	NUM
admet-247	116	12	250	250	NUM
admet-247	116	13	300	300	NUM
admet-247	116	14	350	350	NUM
admet-247	116	15	400	400	NUM
admet-247	116	16	5.0	5.0	NUM
admet-247	116	17	10.0	10.0	NUM
admet-247	116	18	15.0	15.0	NUM
admet-247	116	19	20.0	20.0	NUM
admet-247	116	20	25.0	25.0	NUM
admet-247	116	21	q	q	NOUN
admet-247	116	22	t	t	NOUN
admet-247	117	1	[	[	X
admet-247	117	2			NOUN
admet-247	117	3	g	g	NOUN
admet-247	117	4	/c	/c	PUNCT
admet-247	117	5	m	m	VERB
admet-247	117	6	2	2	NUM
admet-247	117	7	]	]	PUNCT
admet-247	117	8	time	time	NOUN
admet-247	118	1	[	[	X
admet-247	118	2	h	h	X
admet-247	118	3	]	]	X
admet-247	118	4	idm	idm	NOUN
admet-247	118	5	idm+nala	idm+nala	PROPN
admet-247	118	6	b	b	PROPN
admet-247	118	7	cernikova	cernikova	SCONJ
admet-247	118	8	et	et	PROPN
admet-247	118	9	al	al	PROPN
admet-247	118	10	.	.	PROPN
admet-247	118	11	admet	admet	PROPN
admet-247	118	12	&	&	CCONJ
admet-247	118	13	dmpk	dmpk	PROPN
admet-247	118	14	3(4	3(4	NUM
admet-247	118	15	)	)	PUNCT
admet-247	118	16	(	(	PUNCT
admet-247	118	17	2015	2015	NUM
admet-247	118	18	)	)	PUNCT
admet-247	118	19	345	345	NUM
admet-247	118	20	-	-	SYM
admet-247	118	21	351	351	NUM
admet-247	118	22	350	350	NUM
admet-247	118	23	urea	urea	NOUN
admet-247	118	24	and	and	CCONJ
admet-247	118	25	2	2	NUM
admet-247	118	26	-	-	PUNCT
admet-247	118	27	pyrrolidone	pyrrolidone	NOUN
admet-247	118	28	,	,	PUNCT
admet-247	118	29	therefore	therefore	ADV
admet-247	118	30	the	the	DET
admet-247	118	31	supposed	suppose	VERB
admet-247	118	32	mechanism	mechanism	NOUN
admet-247	118	33	of	of	ADP
admet-247	118	34	enhancement	enhancement	NOUN
admet-247	118	35	action	action	NOUN
admet-247	118	36	can	can	AUX
admet-247	118	37	be	be	AUX
admet-247	118	38	as	as	SCONJ
admet-247	118	39	follows	follow	VERB
admet-247	118	40	.	.	PUNCT
admet-247	119	1	as	as	ADP
admet-247	119	2	an	an	DET
admet-247	119	3	urea	urea	NOUN
admet-247	119	4	-	-	PUNCT
admet-247	119	5	like	like	ADJ
admet-247	119	6	derivative	derivative	NOUN
admet-247	119	7	it	it	PRON
admet-247	119	8	can	can	AUX
admet-247	119	9	demonstrate	demonstrate	VERB
admet-247	119	10	moisturizing	moisturizing	NOUN
admet-247	119	11	effect	effect	NOUN
admet-247	119	12	on	on	ADP
admet-247	119	13	the	the	DET
admet-247	119	14	stratum	stratum	NOUN
admet-247	119	15	corneum	corneum	NOUN
admet-247	120	1	[	[	X
admet-247	120	2	38−40	38−40	X
admet-247	120	3	]	]	X
admet-247	120	4	,	,	PUNCT
admet-247	120	5	and	and	CCONJ
admet-247	120	6	,	,	PUNCT
admet-247	120	7	as	as	ADP
admet-247	120	8	a	a	DET
admet-247	120	9	2	2	NUM
admet-247	120	10	-	-	PUNCT
admet-247	120	11	pyrrolidone	pyrrolidone	VERB
admet-247	120	12	-	-	PUNCT
admet-247	120	13	like	like	ADJ
admet-247	120	14	derivative	derivative	NOUN
admet-247	120	15	it	it	PRON
admet-247	120	16	can	can	AUX
admet-247	120	17	exhibit	exhibit	VERB
admet-247	120	18	interactions	interaction	NOUN
admet-247	120	19	preferentially	preferentially	ADV
admet-247	120	20	in	in	ADP
admet-247	120	21	the	the	DET
admet-247	120	22	keratin	keratin	NOUN
admet-247	120	23	region	region	NOUN
admet-247	121	1	[	[	X
admet-247	121	2	39,41	39,41	NUM
admet-247	121	3	]	]	PUNCT
admet-247	121	4	.	.	PUNCT
admet-247	122	1	nevertheless	nevertheless	ADV
admet-247	122	2	,	,	PUNCT
admet-247	122	3	the	the	DET
admet-247	122	4	exact	exact	ADJ
admet-247	122	5	mechanism	mechanism	NOUN
admet-247	122	6	of	of	ADP
admet-247	122	7	action	action	NOUN
admet-247	122	8	of	of	ADP
admet-247	122	9	alaptide	alaptide	NOUN
admet-247	122	10	and	and	CCONJ
admet-247	122	11	effects	effect	NOUN
admet-247	122	12	of	of	ADP
admet-247	122	13	mutual	mutual	ADJ
admet-247	122	14	interactions	interaction	NOUN
admet-247	122	15	of	of	ADP
admet-247	122	16	indomethacin	indomethacin	NOUN
admet-247	122	17	,	,	PUNCT
admet-247	122	18	alaptide	alaptide	NOUN
admet-247	122	19	and	and	CCONJ
admet-247	122	20	skin	skin	NOUN
admet-247	122	21	are	be	AUX
admet-247	122	22	under	under	ADP
admet-247	122	23	investigation	investigation	NOUN
admet-247	122	24	,	,	PUNCT
admet-247	122	25	for	for	ADP
admet-247	122	26	example	example	NOUN
admet-247	122	27	,	,	PUNCT
admet-247	122	28	using	use	VERB
admet-247	122	29	raman	raman	NOUN
admet-247	122	30	or	or	CCONJ
admet-247	122	31	infrared	infrared	ADJ
admet-247	122	32	spectroscopy	spectroscopy	NOUN
admet-247	122	33	for	for	ADP
admet-247	122	34	evaluation	evaluation	NOUN
admet-247	122	35	of	of	ADP
admet-247	122	36	interactions	interaction	NOUN
admet-247	122	37	of	of	ADP
admet-247	122	38	the	the	DET
admet-247	122	39	formulation	formulation	NOUN
admet-247	122	40	and	and	CCONJ
admet-247	122	41	alaptide	alaptide	NOUN
admet-247	122	42	with	with	ADP
admet-247	122	43	the	the	DET
admet-247	122	44	skin	skin	NOUN
admet-247	122	45	structure	structure	NOUN
admet-247	122	46	and	and	CCONJ
admet-247	122	47	using	use	VERB
admet-247	122	48	thermal	thermal	ADJ
admet-247	122	49	methods	method	NOUN
admet-247	122	50	for	for	ADP
admet-247	122	51	understanding	understanding	NOUN
admet-247	122	52	of	of	ADP
admet-247	122	53	interactions	interaction	NOUN
admet-247	122	54	between	between	ADP
admet-247	122	55	indomethacin	indomethacin	NOUN
admet-247	122	56	and	and	CCONJ
admet-247	122	57	alaptide	alaptide	ADJ
admet-247	122	58	.	.	PUNCT
admet-247	123	1	conclusions	conclusion	NOUN
admet-247	123	2	modification	modification	NOUN
admet-247	123	3	of	of	ADP
admet-247	123	4	the	the	DET
admet-247	123	5	permeation	permeation	NOUN
admet-247	123	6	of	of	ADP
admet-247	123	7	indomethacin	indomethacin	NOUN
admet-247	123	8	through	through	ADP
admet-247	123	9	the	the	DET
admet-247	123	10	full	full	ADJ
admet-247	123	11	-	-	PUNCT
admet-247	123	12	thickness	thickness	NOUN
admet-247	123	13	pig	pig	NOUN
admet-247	123	14	ear	ear	VERB
admet-247	123	15	skin	skin	NOUN
admet-247	123	16	by	by	ADP
admet-247	123	17	nanonized	nanonized	ADJ
admet-247	123	18	alaptide	alaptide	NOUN
admet-247	123	19	was	be	AUX
admet-247	123	20	investigated	investigate	VERB
admet-247	123	21	by	by	ADP
admet-247	123	22	in	in	ADP
admet-247	123	23	vitro	vitro	X
admet-247	123	24	screening	screen	VERB
admet-247	123	25	using	use	VERB
admet-247	123	26	the	the	DET
admet-247	123	27	franz	franz	NOUN
admet-247	123	28	diffusion	diffusion	NOUN
admet-247	123	29	cell	cell	NOUN
admet-247	123	30	.	.	PUNCT
admet-247	124	1	nanonized	nanonize	VERB
admet-247	124	2	alaptide	alaptide	NOUN
admet-247	124	3	applied	apply	VERB
admet-247	124	4	in	in	ADP
admet-247	124	5	ratio	ratio	NOUN
admet-247	124	6	1:10	1:10	NUM
admet-247	124	7	related	relate	VERB
admet-247	124	8	to	to	ADP
admet-247	124	9	the	the	DET
admet-247	124	10	amount	amount	NOUN
admet-247	124	11	of	of	ADP
admet-247	124	12	indomethacin	indomethacin	NOUN
admet-247	124	13	significantly	significantly	ADV
admet-247	124	14	enhanced	enhance	VERB
admet-247	124	15	the	the	DET
admet-247	124	16	permeation	permeation	NOUN
admet-247	124	17	of	of	ADP
admet-247	124	18	the	the	DET
admet-247	124	19	drug	drug	NOUN
admet-247	124	20	substance	substance	NOUN
admet-247	124	21	from	from	ADP
admet-247	124	22	the	the	DET
admet-247	124	23	donor	donor	NOUN
admet-247	124	24	vehicle	vehicle	NOUN
admet-247	124	25	of	of	ADP
admet-247	124	26	propylene	propylene	NOUN
admet-247	124	27	glycol	glycol	NOUN
admet-247	124	28	/	/	SYM
admet-247	124	29	water	water	NOUN
admet-247	124	30	(	(	PUNCT
admet-247	124	31	1:1	1:1	NUM
admet-247	124	32	)	)	PUNCT
admet-247	124	33	through	through	ADP
admet-247	124	34	the	the	DET
admet-247	124	35	skin	skin	NOUN
admet-247	124	36	.	.	PUNCT
admet-247	125	1	the	the	DET
admet-247	125	2	calculated	calculated	ADJ
admet-247	125	3	parameters	parameter	NOUN
admet-247	125	4	,	,	PUNCT
admet-247	125	5	such	such	ADJ
admet-247	125	6	as	as	ADP
admet-247	125	7	steady	steady	ADJ
admet-247	125	8	-	-	PUNCT
admet-247	125	9	state	state	NOUN
admet-247	125	10	permeation	permeation	NOUN
admet-247	125	11	flux	flux	NOUN
admet-247	125	12	and	and	CCONJ
admet-247	125	13	permeability	permeability	NOUN
admet-247	125	14	coefficient	coefficient	NOUN
admet-247	125	15	,	,	PUNCT
admet-247	125	16	confirmed	confirm	VERB
admet-247	125	17	the	the	DET
admet-247	125	18	enhancement	enhancement	NOUN
admet-247	125	19	effect	effect	NOUN
admet-247	125	20	of	of	ADP
admet-247	125	21	nanonized	nanonized	ADJ
admet-247	125	22	alaptide	alaptide	NOUN
admet-247	125	23	.	.	PUNCT
admet-247	126	1	overall	overall	ADJ
admet-247	126	2	enhancement	enhancement	NOUN
admet-247	126	3	ratio	ratio	NOUN
admet-247	126	4	er	er	INTJ
admet-247	126	5	is	be	AUX
admet-247	126	6	5.6	5.6	NUM
admet-247	126	7	.	.	PUNCT
admet-247	127	1	the	the	DET
admet-247	127	2	permeated	permeate	VERB
admet-247	127	3	amount	amount	NOUN
admet-247	127	4	of	of	ADP
admet-247	127	5	indomethacin	indomethacin	NOUN
admet-247	127	6	with	with	ADP
admet-247	127	7	nala	nala	PROPN
admet-247	127	8	increased	increase	VERB
admet-247	127	9	rapidly	rapidly	ADV
admet-247	127	10	already	already	ADV
admet-247	127	11	at	at	ADP
admet-247	127	12	the	the	DET
admet-247	127	13	30th	30th	ADJ
admet-247	127	14	minute	minute	NOUN
admet-247	127	15	,	,	PUNCT
admet-247	127	16	when	when	SCONJ
admet-247	127	17	it	it	PRON
admet-247	127	18	reached	reach	VERB
admet-247	127	19	more	more	ADJ
admet-247	127	20	than	than	ADP
admet-247	127	21	5	5	NUM
admet-247	127	22	-	-	ADJ
admet-247	127	23	fold	fold	VERB
admet-247	127	24	higher	high	ADJ
admet-247	127	25	values	value	NOUN
admet-247	127	26	than	than	ADP
admet-247	127	27	indomethacin	indomethacin	NOUN
admet-247	127	28	without	without	ADP
admet-247	127	29	nala	nala	NOUN
admet-247	127	30	.	.	PUNCT
admet-247	128	1	thus	thus	ADV
admet-247	128	2	,	,	PUNCT
admet-247	128	3	it	it	PRON
admet-247	128	4	can	can	AUX
admet-247	128	5	be	be	AUX
admet-247	128	6	summarized	summarize	VERB
admet-247	128	7	that	that	SCONJ
admet-247	128	8	nanonized	nanonize	VERB
admet-247	128	9	alaptide	alaptide	NOUN
admet-247	128	10	can	can	AUX
admet-247	128	11	be	be	AUX
admet-247	128	12	successfully	successfully	ADV
admet-247	128	13	applied	apply	VERB
admet-247	128	14	as	as	ADP
admet-247	128	15	a	a	DET
admet-247	128	16	cpe	cpe	NOUN
admet-247	128	17	,	,	PUNCT
admet-247	128	18	because	because	SCONJ
admet-247	128	19	it	it	PRON
admet-247	128	20	provided	provide	VERB
admet-247	128	21	excellent	excellent	ADJ
admet-247	128	22	rapid	rapid	ADJ
admet-247	128	23	onset	onset	NOUN
admet-247	128	24	of	of	ADP
admet-247	128	25	enhancement	enhancement	NOUN
admet-247	128	26	effect	effect	NOUN
admet-247	128	27	,	,	PUNCT
admet-247	128	28	which	which	PRON
admet-247	128	29	is	be	AUX
admet-247	128	30	an	an	DET
admet-247	128	31	important	important	ADJ
admet-247	128	32	requirement	requirement	NOUN
admet-247	128	33	for	for	ADP
admet-247	128	34	chemical	chemical	ADJ
admet-247	128	35	permeation	permeation	NOUN
admet-247	128	36	enhancers	enhancer	NOUN
admet-247	128	37	.	.	PUNCT
admet-247	129	1	it	it	PRON
admet-247	129	2	is	be	AUX
admet-247	129	3	evident	evident	ADJ
admet-247	129	4	that	that	SCONJ
admet-247	129	5	alaptide	alaptide	NOUN
admet-247	129	6	modifies	modify	VERB
admet-247	129	7	skin	skin	NOUN
admet-247	129	8	structure	structure	NOUN
admet-247	129	9	,	,	PUNCT
admet-247	129	10	which	which	PRON
admet-247	129	11	results	result	VERB
admet-247	129	12	in	in	ADP
admet-247	129	13	significantly	significantly	ADV
admet-247	129	14	enhanced	enhance	VERB
admet-247	129	15	permeation	permeation	NOUN
admet-247	129	16	at	at	ADP
admet-247	129	17	long	long	ADJ
admet-247	129	18	-	-	PUNCT
admet-247	129	19	term	term	NOUN
admet-247	129	20	application	application	NOUN
admet-247	129	21	.	.	PUNCT
admet-247	130	1	acknowledgements	acknowledgement	NOUN
admet-247	130	2	:	:	PUNCT
admet-247	130	3	this	this	DET
admet-247	130	4	study	study	NOUN
admet-247	130	5	was	be	AUX
admet-247	130	6	supported	support	VERB
admet-247	130	7	by	by	ADP
admet-247	130	8	iga	iga	PROPN
admet-247	130	9	vfu	vfu	PROPN
admet-247	130	10	brno	brno	NOUN
admet-247	130	11	302/2015	302/2015	NUM
admet-247	130	12	/	/	SYM
admet-247	130	13	faf	faf	NOUN
admet-247	130	14	and	and	CCONJ
admet-247	130	15	by	by	ADP
admet-247	130	16	the	the	DET
admet-247	130	17	technology	technology	NOUN
admet-247	130	18	agency	agency	NOUN
admet-247	130	19	of	of	ADP
admet-247	130	20	the	the	DET
admet-247	130	21	czech	czech	PROPN
admet-247	130	22	republic	republic	NOUN
admet-247	130	23	ta04010065	ta04010065	PROPN
admet-247	130	24	.	.	PUNCT
admet-247	131	1	references	reference	NOUN
admet-247	131	2	[	[	X
admet-247	131	3	1	1	X
admet-247	131	4	]	]	PUNCT
admet-247	131	5	j.	j.	PROPN
admet-247	131	6	jampilek	jampilek	PROPN
admet-247	131	7	,	,	PUNCT
admet-247	131	8	k.	k.	PROPN
admet-247	131	9	brychtova	brychtova	PROPN
admet-247	131	10	.	.	PUNCT
admet-247	132	1	medicinal	medicinal	ADJ
admet-247	132	2	research	research	NOUN
admet-247	132	3	reviews	review	NOUN
admet-247	132	4	32	32	NUM
admet-247	132	5	(	(	PUNCT
admet-247	132	6	2012	2012	NUM
admet-247	132	7	)	)	PUNCT
admet-247	133	1	907–947	907–947	NUM
admet-247	133	2	.	.	PUNCT
admet-247	134	1	[	[	X
admet-247	134	2	2	2	X
admet-247	134	3	]	]	PUNCT
admet-247	134	4	j.	j.	PROPN
admet-247	134	5	jampilek	jampilek	PROPN
admet-247	134	6	.	.	PUNCT
admet-247	134	7	journal	journal	PROPN
admet-247	134	8	of	of	ADP
admet-247	134	9	bioequivalence	bioequivalence	NOUN
admet-247	134	10	&	&	CCONJ
admet-247	134	11	bioavailability	bioavailability	NOUN
admet-247	134	12	5	5	NUM
admet-247	134	13	(	(	PUNCT
admet-247	134	14	2013	2013	NUM
admet-247	134	15	)	)	PUNCT
admet-247	134	16	233–235	233–235	NUM
admet-247	134	17	.	.	PUNCT
admet-247	135	1	[	[	X
admet-247	135	2	3	3	X
admet-247	135	3	]	]	X
admet-247	135	4	d.	d.	PROPN
admet-247	135	5	kaushik	kaushik	PROPN
admet-247	135	6	,	,	PUNCT
admet-247	135	7	p.	p.	PROPN
admet-247	135	8	batheja	batheja	PROPN
admet-247	135	9	,	,	PUNCT
admet-247	135	10	b.	b.	PROPN
admet-247	135	11	kilfoyle	kilfoyle	PROPN
admet-247	135	12	,	,	PUNCT
admet-247	135	13	v.	v.	PROPN
admet-247	135	14	rai	rai	PROPN
admet-247	135	15	,	,	PUNCT
admet-247	135	16	b.	b.	PROPN
admet-247	135	17	michniak	michniak	PROPN
admet-247	135	18	-	-	PUNCT
admet-247	135	19	kohn	kohn	PROPN
admet-247	135	20	.	.	PUNCT
admet-247	136	1	expert	expert	ADJ
admet-247	136	2	opinion	opinion	NOUN
admet-247	136	3	on	on	ADP
admet-247	136	4	drug	drug	NOUN
admet-247	136	5	delivery	delivery	NOUN
admet-247	136	6	5	5	NUM
admet-247	136	7	(	(	PUNCT
admet-247	136	8	2008	2008	NUM
admet-247	136	9	)	)	PUNCT
admet-247	137	1	517–529	517–529	NUM
admet-247	137	2	.	.	PUNCT
admet-247	138	1	[	[	X
admet-247	138	2	4	4	X
admet-247	138	3	]	]	X
admet-247	138	4	e.	e.	PROPN
admet-247	138	5	kasafirek	kasafirek	PROPN
admet-247	138	6	,	,	PUNCT
admet-247	138	7	j.	j.	PROPN
admet-247	138	8	vanzura	vanzura	PROPN
admet-247	138	9	,	,	PUNCT
admet-247	138	10	i.	i.	PROPN
admet-247	138	11	krejci	krejci	PROPN
admet-247	138	12	,	,	PUNCT
admet-247	138	13	j.	j.	PROPN
admet-247	138	14	krepelka	krepelka	PROPN
admet-247	138	15	,	,	PUNCT
admet-247	138	16	a.	a.	NOUN
admet-247	138	17	dlabac	dlabac	NOUN
admet-247	138	18	,	,	PUNCT
admet-247	138	19	m.	m.	NOUN
admet-247	138	20	valchar	valchar	PROPN
admet-247	138	21	.	.	PUNCT
admet-247	139	1	(	(	PUNCT
admet-247	139	2	united	united	PROPN
admet-247	139	3	pharmaceutical	pharmaceutical	PROPN
admet-247	139	4	works	works	PROPN
admet-247	139	5	&	&	CCONJ
admet-247	139	6	research	research	PROPN
admet-247	139	7	institute	institute	PROPN
admet-247	139	8	for	for	ADP
admet-247	139	9	pharmacy	pharmacy	NOUN
admet-247	139	10	and	and	CCONJ
admet-247	139	11	biochemistry	biochemistry	NOUN
admet-247	139	12	)	)	PUNCT
admet-247	139	13	,	,	PUNCT
admet-247	139	14	belg	belg	PROPN
admet-247	139	15	.	.	PUNCT
admet-247	140	1	897843	897843	NUM
admet-247	140	2	(	(	PUNCT
admet-247	140	3	1984	1984	NUM
admet-247	140	4	)	)	PUNCT
admet-247	140	5	&	&	CCONJ
admet-247	140	6	cs	cs	PROPN
admet-247	140	7	231227	231227	NUM
admet-247	140	8	(	(	PUNCT
admet-247	140	9	1986	1986	NUM
admet-247	140	10	)	)	PUNCT
admet-247	140	11	.	.	PUNCT
admet-247	141	1	[	[	X
admet-247	141	2	5	5	X
admet-247	141	3	]	]	PUNCT
admet-247	141	4	s.	s.	PROPN
admet-247	141	5	radl	radl	PROPN
admet-247	141	6	,	,	PUNCT
admet-247	141	7	e.	e.	PROPN
admet-247	141	8	kasafirek	kasafirek	PROPN
admet-247	141	9	,	,	PUNCT
admet-247	141	10	i.	i.	PROPN
admet-247	141	11	krejci	krejci	PROPN
admet-247	141	12	.	.	PUNCT
admet-247	142	1	drugs	drug	NOUN
admet-247	142	2	of	of	ADP
admet-247	142	3	the	the	DET
admet-247	142	4	future	future	ADJ
admet-247	142	5	15	15	NUM
admet-247	142	6	(	(	PUNCT
admet-247	142	7	1990	1990	NUM
admet-247	142	8	)	)	PUNCT
admet-247	142	9	445–447	445–447	NUM
admet-247	142	10	.	.	PUNCT
admet-247	143	1	[	[	X
admet-247	143	2	6	6	NUM
admet-247	143	3	]	]	X
admet-247	143	4	j.a	j.a	PROPN
admet-247	143	5	.	.	PROPN
admet-247	143	6	mcgrath	mcgrath	PROPN
admet-247	143	7	,	,	PUNCT
admet-247	143	8	r.a	r.a	PROPN
admet-247	143	9	.	.	PROPN
admet-247	143	10	eady	eady	PROPN
admet-247	143	11	,	,	PUNCT
admet-247	143	12	f.m	f.m	PROPN
admet-247	143	13	.	.	PROPN
admet-247	143	14	pope	pope	PROPN
admet-247	143	15	.	.	PUNCT
admet-247	144	1	rook	rook	NOUN
admet-247	144	2	's	's	PART
admet-247	144	3	textbook	textbook	NOUN
admet-247	144	4	of	of	ADP
admet-247	144	5	dermatology	dermatology	NOUN
admet-247	144	6	,	,	PUNCT
admet-247	144	7	7th	7th	ADJ
admet-247	144	8	ed	ed	NOUN
admet-247	144	9	.	.	PUNCT
admet-247	145	1	t.	t.	NOUN
admet-247	145	2	burns	burn	NOUN
admet-247	145	3	,	,	PUNCT
admet-247	145	4	s.	s.	PROPN
admet-247	145	5	breathnach	breathnach	PROPN
admet-247	145	6	,	,	PUNCT
admet-247	145	7	n.	n.	PROPN
admet-247	145	8	cox	cox	PROPN
admet-247	145	9	,	,	PUNCT
admet-247	145	10	c.	c.	PROPN
admet-247	145	11	griffiths	griffiths	PROPN
admet-247	145	12	,	,	PUNCT
admet-247	145	13	(	(	PUNCT
admet-247	145	14	eds	ed	NOUN
admet-247	145	15	)	)	PUNCT
admet-247	145	16	.	.	PUNCT
admet-247	145	17	,	,	PUNCT
admet-247	145	18	blackwell	blackwell	PROPN
admet-247	145	19	publishing	publishing	NOUN
admet-247	145	20	,	,	PUNCT
admet-247	145	21	oxford	oxford	PROPN
admet-247	145	22	,	,	PUNCT
admet-247	145	23	2004	2004	NUM
admet-247	145	24	,	,	PUNCT
admet-247	145	25	pp	pp	ADJ
admet-247	145	26	.	.	PUNCT
admet-247	146	1	3–7	3–7	NUM
admet-247	146	2	.	.	PUNCT
admet-247	147	1	[	[	X
admet-247	147	2	7	7	X
admet-247	147	3	]	]	X
admet-247	147	4	w.	w.	PROPN
admet-247	147	5	james	james	PROPN
admet-247	147	6	,	,	PUNCT
admet-247	147	7	t.	t.	PROPN
admet-247	147	8	berger	berger	PROPN
admet-247	147	9	,	,	PUNCT
admet-247	147	10	d.	d.	PROPN
admet-247	147	11	elston	elston	PROPN
admet-247	147	12	.	.	PUNCT
admet-247	147	13	andrews	andrews	PROPN
admet-247	147	14	'	'	PART
admet-247	147	15	diseases	disease	NOUN
admet-247	147	16	of	of	ADP
admet-247	147	17	the	the	DET
admet-247	147	18	skin	skin	NOUN
admet-247	147	19	:	:	PUNCT
admet-247	147	20	clinical	clinical	ADJ
admet-247	147	21	dermatology	dermatology	NOUN
admet-247	147	22	,	,	PUNCT
admet-247	147	23	10th	10th	ADJ
admet-247	147	24	ed	ed	NOUN
admet-247	147	25	.	.	PROPN
admet-247	147	26	,	,	PUNCT
admet-247	147	27	saunders	saunders	PROPN
admet-247	147	28	-	-	PUNCT
admet-247	147	29	elsevier	elsevier	PROPN
admet-247	147	30	,	,	PUNCT
admet-247	147	31	philadelphia	philadelphia	PROPN
admet-247	147	32	,	,	PUNCT
admet-247	147	33	2006	2006	NUM
admet-247	147	34	,	,	PUNCT
admet-247	147	35	pp	pp	ADV
admet-247	147	36	.	.	PUNCT
admet-247	148	1	5–6	5–6	VERB
admet-247	148	2	.	.	PUNCT
admet-247	149	1	[	[	X
admet-247	149	2	8	8	NUM
admet-247	149	3	]	]	X
admet-247	149	4	f.m	f.m	PROPN
admet-247	149	5	.	.	PROPN
admet-247	149	6	watt	watt	NOUN
admet-247	149	7	.	.	PUNCT
admet-247	150	1	bioessays	bioessay	NOUN
admet-247	150	2	8	8	NUM
admet-247	150	3	(	(	PUNCT
admet-247	150	4	1988	1988	NUM
admet-247	150	5	)	)	PUNCT
admet-247	150	6	163–167	163–167	NUM
admet-247	150	7	.	.	PUNCT
admet-247	151	1	[	[	X
admet-247	151	2	9	9	NUM
admet-247	151	3	]	]	PUNCT
admet-247	151	4	l.	l.	PROPN
admet-247	151	5	korbova	korbova	PROPN
admet-247	151	6	,	,	PUNCT
admet-247	151	7	j.	j.	PROPN
admet-247	151	8	cizkova	cizkova	PROPN
admet-247	151	9	,	,	PUNCT
admet-247	151	10	j.	j.	PROPN
admet-247	151	11	kohout	kohout	PROPN
admet-247	151	12	,	,	PUNCT
admet-247	151	13	e.	e.	PROPN
admet-247	151	14	kasafirek	kasafirek	PROPN
admet-247	151	15	,	,	PUNCT
admet-247	151	16	i.	i.	PROPN
admet-247	151	17	krejci	krejci	PROPN
admet-247	151	18	,	,	PUNCT
admet-247	151	19	j.	j.	PROPN
admet-247	151	20	vanzura	vanzura	PROPN
admet-247	151	21	.	.	PUNCT
admet-247	152	1	journal	journal	PROPN
admet-247	152	2	of	of	ADP
admet-247	152	3	czech	czech	PROPN
admet-247	152	4	physicians	physician	NOUN
admet-247	152	5	127	127	NUM
admet-247	152	6	(	(	PUNCT
admet-247	152	7	1988	1988	NUM
admet-247	152	8	)	)	PUNCT
admet-247	152	9	1574	1574	NUM
admet-247	152	10	-	-	SYM
admet-247	152	11	1577	1577	NUM
admet-247	152	12	.	.	PUNCT
admet-247	153	1	[	[	X
admet-247	153	2	10	10	NUM
admet-247	153	3	]	]	PUNCT
admet-247	153	4	l.	l.	PROPN
admet-247	153	5	korbova	korbova	PROPN
admet-247	153	6	,	,	PUNCT
admet-247	153	7	j.	j.	PROPN
admet-247	153	8	kohout	kohout	PROPN
admet-247	153	9	,	,	PUNCT
admet-247	153	10	e.	e.	PROPN
admet-247	153	11	kasafirek	kasafirek	PROPN
admet-247	153	12	.	.	PUNCT
admet-247	154	1	gastroenterology	gastroenterology	NOUN
admet-247	154	2	and	and	CCONJ
admet-247	154	3	hepatology	hepatology	NOUN
admet-247	154	4	48	48	NUM
admet-247	154	5	(	(	PUNCT
admet-247	154	6	1994	1994	NUM
admet-247	154	7	)	)	PUNCT
admet-247	154	8	170	170	NUM
admet-247	154	9	-	-	SYM
admet-247	154	10	182	182	NUM
admet-247	154	11	.	.	PUNCT
admet-247	155	1	[	[	X
admet-247	155	2	11	11	NUM
admet-247	155	3	]	]	X
admet-247	155	4	e.	e.	PROPN
admet-247	155	5	kasafirek	kasafirek	PROPN
admet-247	155	6	,	,	PUNCT
admet-247	155	7	l.	l.	PROPN
admet-247	155	8	korbova	korbova	PROPN
admet-247	155	9	,	,	PUNCT
admet-247	155	10	j.	j.	PROPN
admet-247	155	11	kohout	kohout	PROPN
admet-247	155	12	,	,	PUNCT
admet-247	155	13	m.	m.	PROPN
admet-247	155	14	jiraskova	jiraskova	PROPN
admet-247	155	15	,	,	PUNCT
admet-247	155	16	i.	i.	PROPN
admet-247	155	17	krejci	krejci	PROPN
admet-247	155	18	,	,	PUNCT
admet-247	155	19	a.	a.	NOUN
admet-247	155	20	galatik	galatik	NOUN
admet-247	155	21	.	.	PUNCT
admet-247	156	1	(	(	PUNCT
admet-247	156	2	united	united	PROPN
admet-247	156	3	pharmaceutical	pharmaceutical	PROPN
admet-247	156	4	works	works	PROPN
admet-247	156	5	&	&	CCONJ
admet-247	156	6	research	research	PROPN
admet-247	156	7	institute	institute	PROPN
admet-247	156	8	for	for	ADP
admet-247	156	9	pharmacy	pharmacy	NOUN
admet-247	156	10	and	and	CCONJ
admet-247	156	11	biochemistry	biochemistry	NOUN
admet-247	156	12	)	)	PUNCT
admet-247	156	13	,	,	PUNCT
admet-247	156	14	cs	cs	PROPN
admet-247	156	15	276270	276270	NUM
admet-247	156	16	(	(	PUNCT
admet-247	156	17	1992	1992	NUM
admet-247	156	18	)	)	PUNCT
admet-247	156	19	.	.	PUNCT
admet-247	157	1	[	[	X
admet-247	157	2	12	12	NUM
admet-247	157	3	]	]	PUNCT
admet-247	157	4	r.	r.	PROPN
admet-247	157	5	opatrilova	opatrilova	PROPN
admet-247	157	6	,	,	PUNCT
admet-247	157	7	a.	a.	PROPN
admet-247	157	8	cernikova	cernikova	PROPN
admet-247	157	9	,	,	PUNCT
admet-247	157	10	l.	l.	PROPN
admet-247	157	11	coufalova	coufalova	PROPN
admet-247	157	12	,	,	PUNCT
admet-247	157	13	j.	j.	PROPN
admet-247	157	14	dohnal	dohnal	PROPN
admet-247	157	15	,	,	PUNCT
admet-247	157	16	j.	j.	PROPN
admet-247	157	17	jampilek	jampilek	PROPN
admet-247	157	18	.	.	PUNCT
admet-247	158	1	the	the	DET
admet-247	158	2	scientific	scientific	ADJ
admet-247	158	3	world	world	NOUN
admet-247	158	4	journal	journal	PROPN
admet-247	158	5	2013	2013	NUM
admet-247	158	6	(	(	PUNCT
admet-247	158	7	2013	2013	NUM
admet-247	158	8	)	)	PUNCT
admet-247	158	9	,	,	PUNCT
admet-247	158	10	article	article	NOUN
admet-247	158	11	i	i	PROPN
admet-247	158	12	d	d	PROPN
admet-247	158	13	787283	787283	NUM
admet-247	158	14	(	(	PUNCT
admet-247	158	15	8	8	NUM
admet-247	158	16	pages	page	NOUN
admet-247	158	17	)	)	PUNCT
admet-247	158	18	,	,	PUNCT
admet-247	158	19	http://www.hindawi.com/journals/tswj/2013/787283/.	http://www.hindawi.com/journals/tswj/2013/787283/.	PROPN
admet-247	158	20	[	[	X
admet-247	158	21	13	13	NUM
admet-247	158	22	]	]	PUNCT
admet-247	158	23	r.	r.	PROPN
admet-247	158	24	lapka	lapka	PROPN
admet-247	158	25	.	.	PUNCT
admet-247	159	1	journal	journal	PROPN
admet-247	159	2	of	of	ADP
admet-247	159	3	pharmacy	pharmacy	NOUN
admet-247	159	4	and	and	CCONJ
admet-247	159	5	pharmacology	pharmacology	NOUN
admet-247	159	6	43	43	NUM
admet-247	159	7	(	(	PUNCT
admet-247	159	8	1991	1991	NUM
admet-247	159	9	)	)	PUNCT
admet-247	159	10	874	874	NUM
admet-247	159	11	-	-	SYM
admet-247	159	12	876	876	NUM
admet-247	159	13	.	.	PUNCT
admet-247	160	1	[	[	X
admet-247	160	2	14	14	NUM
admet-247	160	3	]	]	PUNCT
admet-247	160	4	j.	j.	PROPN
admet-247	160	5	vanzura	vanzura	PROPN
admet-247	160	6	,	,	PUNCT
admet-247	160	7	k.	k.	PROPN
admet-247	160	8	kosar	kosar	PROPN
admet-247	160	9	,	,	PUNCT
admet-247	160	10	e.	e.	PROPN
admet-247	160	11	kasafirek	kasafirek	PROPN
admet-247	160	12	.	.	PUNCT
admet-247	161	1	toxicology	toxicology	NOUN
admet-247	161	2	letters	letter	NOUN
admet-247	161	3	31	31	NUM
admet-247	161	4	(	(	PUNCT
admet-247	161	5	1986	1986	NUM
admet-247	161	6	)	)	PUNCT
admet-247	161	7	189	189	NUM
admet-247	161	8	-	-	SYM
admet-247	161	9	193	193	NUM
admet-247	161	10	.	.	PUNCT
admet-247	162	1	[	[	X
admet-247	162	2	15	15	NUM
admet-247	162	3	]	]	PUNCT
admet-247	162	4	k.	k.	PROPN
admet-247	162	5	kosar	kosar	PROPN
admet-247	162	6	,	,	PUNCT
admet-247	162	7	j.	j.	PROPN
admet-247	162	8	vanzura	vanzura	PROPN
admet-247	162	9	.	.	PUNCT
admet-247	163	1	pharmazie	pharmazie	PROPN
admet-247	163	2	43	43	NUM
admet-247	163	3	(	(	PUNCT
admet-247	163	4	1988	1988	NUM
admet-247	163	5	)	)	PUNCT
admet-247	163	6	715	715	NUM
admet-247	163	7	-	-	SYM
admet-247	163	8	716	716	NUM
admet-247	163	9	.	.	PUNCT
admet-247	164	1	http://www.hindawi.com/journals/tswj/2013/787283/	http://www.hindawi.com/journals/tswj/2013/787283/	ADV
admet-247	164	2	admet	admet	PROPN
admet-247	164	3	&	&	CCONJ
admet-247	164	4	dmpk	dmpk	PROPN
admet-247	164	5	3(4	3(4	NUM
admet-247	164	6	)	)	PUNCT
admet-247	164	7	(	(	PUNCT
admet-247	164	8	2015	2015	NUM
admet-247	164	9	)	)	PUNCT
admet-247	164	10	345	345	NUM
admet-247	164	11	-	-	SYM
admet-247	164	12	351	351	NUM
admet-247	164	13	skin	skin	NOUN
admet-247	164	14	permeation	permeation	NOUN
admet-247	164	15	of	of	ADP
admet-247	164	16	indomethacin	indomethacin	PROPN
admet-247	164	17	doi	doi	NOUN
admet-247	164	18	:	:	PUNCT
admet-247	164	19	10.5599	10.5599	NUM
admet-247	164	20	/	/	SYM
admet-247	164	21	admet.3.4.247	admet.3.4.247	NOUN
admet-247	164	22	351	351	NUM
admet-247	164	23	[	[	X
admet-247	164	24	16	16	NUM
admet-247	164	25	]	]	X
admet-247	164	26	j.	j.	PROPN
admet-247	164	27	jampilek	jampilek	PROPN
admet-247	164	28	,	,	PUNCT
admet-247	164	29	r.	r.	PROPN
admet-247	164	30	opatrilova	opatrilova	PROPN
admet-247	164	31	,	,	PUNCT
admet-247	164	32	a.	a.	NOUN
admet-247	164	33	rezacova	rezacova	PROPN
admet-247	164	34	,	,	PUNCT
admet-247	164	35	z	z	NOUN
admet-247	164	36	oktabec	oktabec	NOUN
admet-247	164	37	,	,	PUNCT
admet-247	164	38	j.	j.	PROPN
admet-247	164	39	dohnal	dohnal	PROPN
admet-247	164	40	.	.	PUNCT
admet-247	165	1	(	(	PUNCT
admet-247	165	2	faculty	faculty	NOUN
admet-247	165	3	of	of	ADP
admet-247	165	4	pharmacy	pharmacy	NOUN
admet-247	165	5	,	,	PUNCT
admet-247	165	6	university	university	NOUN
admet-247	165	7	of	of	ADP
admet-247	165	8	veterinary	veterinary	ADJ
admet-247	165	9	and	and	CCONJ
admet-247	165	10	pharmaceutical	pharmaceutical	NOUN
admet-247	165	11	sciences	science	NOUN
admet-247	165	12	brno	brno	NOUN
admet-247	165	13	)	)	PUNCT
admet-247	165	14	,	,	PUNCT
admet-247	165	15	wo/2014/019556	wo/2014/019556	PROPN
admet-247	165	16	a1	a1	NOUN
admet-247	165	17	(	(	PUNCT
admet-247	165	18	2014	2014	NUM
admet-247	165	19	)	)	PUNCT
admet-247	165	20	.	.	PUNCT
admet-247	166	1	[	[	X
admet-247	166	2	17	17	NUM
admet-247	166	3	]	]	PUNCT
admet-247	166	4	drug	drug	NOUN
admet-247	166	5	bank	bank	NOUN
admet-247	166	6	–	–	PUNCT
admet-247	166	7	indomethacin	indomethacin	PROPN
admet-247	166	8	,	,	PUNCT
admet-247	166	9	http://www.drugbank.ca/drugs/db00328	http://www.drugbank.ca/drugs/db00328	PROPN
admet-247	166	10	(	(	PUNCT
admet-247	166	11	october	october	PROPN
admet-247	166	12	28	28	NUM
admet-247	166	13	,	,	PUNCT
admet-247	166	14	2015	2015	NUM
admet-247	166	15	)	)	PUNCT
admet-247	166	16	.	.	PUNCT
admet-247	167	1	[	[	X
admet-247	167	2	18	18	NUM
admet-247	167	3	]	]	PUNCT
admet-247	167	4	j.	j.	PROPN
admet-247	167	5	jampilek	jampilek	PROPN
admet-247	167	6	,	,	PUNCT
admet-247	167	7	r.	r.	PROPN
admet-247	167	8	opatrilova	opatrilova	PROPN
admet-247	167	9	,	,	PUNCT
admet-247	167	10	l.	l.	PROPN
admet-247	167	11	coufalova	coufalova	PROPN
admet-247	167	12	,	,	PUNCT
admet-247	167	13	a.	a.	PROPN
admet-247	167	14	cernikova	cernikova	PROPN
admet-247	167	15	,	,	PUNCT
admet-247	167	16	j.	j.	PROPN
admet-247	167	17	dohnal	dohnal	PROPN
admet-247	167	18	.	.	PUNCT
admet-247	168	1	(	(	PUNCT
admet-247	168	2	faculty	faculty	NOUN
admet-247	168	3	of	of	ADP
admet-247	168	4	pharmacy	pharmacy	NOUN
admet-247	168	5	,	,	PUNCT
admet-247	168	6	university	university	NOUN
admet-247	168	7	of	of	ADP
admet-247	168	8	veterinary	veterinary	ADJ
admet-247	168	9	and	and	CCONJ
admet-247	168	10	pharmaceutical	pharmaceutical	NOUN
admet-247	168	11	sciences	science	NOUN
admet-247	168	12	brno	brno	NOUN
admet-247	168	13	)	)	PUNCT
admet-247	168	14	,	,	PUNCT
admet-247	168	15	wo/2013/020527	wo/2013/020527	PROPN
admet-247	168	16	a1	a1	NOUN
admet-247	168	17	(	(	PUNCT
admet-247	168	18	2013	2013	NUM
admet-247	168	19	)	)	PUNCT
admet-247	168	20	.	.	PUNCT
admet-247	169	1	[	[	X
admet-247	169	2	19	19	NUM
admet-247	169	3	]	]	X
admet-247	169	4	j.	j.	PROPN
admet-247	169	5	jampilek	jampilek	PROPN
admet-247	169	6	,	,	PUNCT
admet-247	169	7	r.	r.	PROPN
admet-247	169	8	opatrilova	opatrilova	PROPN
admet-247	169	9	,	,	PUNCT
admet-247	169	10	l.	l.	PROPN
admet-247	169	11	dvorakova	dvorakova	PROPN
admet-247	169	12	,	,	PUNCT
admet-247	169	13	k.	k.	PROPN
admet-247	169	14	brychtova	brychtova	PROPN
admet-247	169	15	,	,	PUNCT
admet-247	169	16	j.	j.	PROPN
admet-247	169	17	dohnal	dohnal	PROPN
admet-247	169	18	.	.	PUNCT
admet-247	170	1	(	(	PUNCT
admet-247	170	2	faculty	faculty	NOUN
admet-247	170	3	of	of	ADP
admet-247	170	4	pharmacy	pharmacy	NOUN
admet-247	170	5	,	,	PUNCT
admet-247	170	6	university	university	NOUN
admet-247	170	7	of	of	ADP
admet-247	170	8	veterinary	veterinary	ADJ
admet-247	170	9	and	and	CCONJ
admet-247	170	10	pharmaceutical	pharmaceutical	NOUN
admet-247	170	11	sciences	science	NOUN
admet-247	170	12	brno	brno	NOUN
admet-247	170	13	)	)	PUNCT
admet-247	170	14	,	,	PUNCT
admet-247	170	15	cz	cz	NOUN
admet-247	170	16	304915	304915	NUM
admet-247	170	17	b6	b6	NOUN
admet-247	170	18	(	(	PUNCT
admet-247	170	19	2014	2014	NUM
admet-247	170	20	)	)	PUNCT
admet-247	170	21	.	.	PUNCT
admet-247	171	1	[	[	X
admet-247	171	2	20	20	NUM
admet-247	171	3	]	]	PUNCT
admet-247	171	4	r.	r.	PROPN
admet-247	171	5	opatrilova	opatrilova	PROPN
admet-247	171	6	,	,	PUNCT
admet-247	171	7	j.	j.	PROPN
admet-247	171	8	jampilek	jampilek	PROPN
admet-247	171	9	.	.	PUNCT
admet-247	172	1	admet	admet	PROPN
admet-247	172	2	&	&	CCONJ
admet-247	172	3	dmpk	dmpk	PROPN
admet-247	172	4	2	2	NUM
admet-247	172	5	(	(	PUNCT
admet-247	172	6	2014	2014	NUM
admet-247	172	7	)	)	PUNCT
admet-247	172	8	,	,	PUNCT
admet-247	172	9	56–62	56–62	NUM
admet-247	172	10	.	.	PUNCT
admet-247	173	1	[	[	X
admet-247	173	2	21	21	NUM
admet-247	173	3	]	]	PUNCT
admet-247	173	4	a.	a.	NOUN
admet-247	173	5	cernikova	cernikova	PROPN
admet-247	173	6	,	,	PUNCT
admet-247	173	7	r.	r.	PROPN
admet-247	173	8	opatrilova	opatrilova	PROPN
admet-247	173	9	,	,	PUNCT
admet-247	173	10	j.	j.	PROPN
admet-247	173	11	jampilek	jampilek	PROPN
admet-247	173	12	.	.	PUNCT
admet-247	174	1	military	military	ADJ
admet-247	174	2	medical	medical	ADJ
admet-247	174	3	science	science	NOUN
admet-247	174	4	letters	letter	NOUN
admet-247	174	5	83	83	NUM
admet-247	174	6	(	(	PUNCT
admet-247	174	7	2014	2014	NUM
admet-247	174	8	)	)	PUNCT
admet-247	174	9	34–39	34–39	NUM
admet-247	174	10	,	,	PUNCT
admet-247	174	11	http://mmsl.cz/vicms/soubory/pdf/mmsl_2014_1_6__www.pdf	http://mmsl.cz/vicms/soubory/pdf/mmsl_2014_1_6__www.pdf	X
admet-247	174	12	.	.	PUNCT
admet-247	175	1	[	[	X
admet-247	175	2	22	22	NUM
admet-247	175	3	]	]	PUNCT
admet-247	175	4	a.	a.	NOUN
admet-247	175	5	cernikova	cernikova	PROPN
admet-247	175	6	,	,	PUNCT
admet-247	175	7	r.	r.	PROPN
admet-247	175	8	opatrilova	opatrilova	PROPN
admet-247	175	9	,	,	PUNCT
admet-247	175	10	p.	p.	PROPN
admet-247	175	11	bobal	bobal	PROPN
admet-247	175	12	,	,	PUNCT
admet-247	175	13	j.	j.	PROPN
admet-247	175	14	jampilek	jampilek	PROPN
admet-247	175	15	.	.	PUNCT
admet-247	176	1	admet	admet	PROPN
admet-247	176	2	&	&	CCONJ
admet-247	176	3	dmpk	dmpk	PROPN
admet-247	176	4	2	2	NUM
admet-247	176	5	(	(	PUNCT
admet-247	176	6	2014	2014	NUM
admet-247	176	7	)	)	PUNCT
admet-247	176	8	248	248	NUM
admet-247	176	9	-	-	SYM
admet-247	176	10	253	253	NUM
admet-247	176	11	.	.	PUNCT
admet-247	177	1	[	[	X
admet-247	177	2	23	23	NUM
admet-247	177	3	]	]	X
admet-247	177	4	e.	e.	PROPN
admet-247	177	5	kasafirek	kasafirek	PROPN
admet-247	177	6	,	,	PUNCT
admet-247	177	7	m.	m.	NOUN
admet-247	177	8	rybak	rybak	PROPN
admet-247	177	9	,	,	PUNCT
admet-247	177	10	i.	i.	PROPN
admet-247	177	11	krejci	krejci	PROPN
admet-247	177	12	,	,	PUNCT
admet-247	177	13	a.	a.	PROPN
admet-247	177	14	sturs	sturs	PROPN
admet-247	177	15	,	,	PUNCT
admet-247	177	16	e.	e.	PROPN
admet-247	177	17	krepela	krepela	PROPN
admet-247	177	18	,	,	PUNCT
admet-247	177	19	a.	a.	PROPN
admet-247	177	20	sedo	sedo	PROPN
admet-247	177	21	.	.	PUNCT
admet-247	178	1	life	life	NOUN
admet-247	178	2	science	science	NOUN
admet-247	178	3	50	50	NUM
admet-247	178	4	(	(	PUNCT
admet-247	178	5	1992	1992	NUM
admet-247	178	6	)	)	PUNCT
admet-247	178	7	187–193	187–193	NUM
admet-247	178	8	.	.	PUNCT
admet-247	179	1	[	[	X
admet-247	179	2	24	24	NUM
admet-247	179	3	]	]	PUNCT
admet-247	179	4	m.	m.	NOUN
admet-247	179	5	dousa	dousa	NOUN
admet-247	179	6	,	,	PUNCT
admet-247	179	7	k.	k.	PROPN
admet-247	179	8	lemr	lemr	PROPN
admet-247	179	9	.	.	PUNCT
admet-247	180	1	journal	journal	NOUN
admet-247	180	2	of	of	ADP
admet-247	180	3	separation	separation	NOUN
admet-247	180	4	science	science	NOUN
admet-247	180	5	34	34	NUM
admet-247	180	6	(	(	PUNCT
admet-247	180	7	2011	2011	NUM
admet-247	180	8	)	)	PUNCT
admet-247	180	9	,	,	PUNCT
admet-247	180	10	1402–1406	1402–1406	NUM
admet-247	180	11	.	.	PUNCT
admet-247	181	1	[	[	X
admet-247	181	2	25	25	NUM
admet-247	181	3	]	]	PUNCT
admet-247	181	4	oecd	oecd	PROPN
admet-247	181	5	guidelines	guideline	NOUN
admet-247	181	6	for	for	ADP
admet-247	181	7	the	the	DET
admet-247	181	8	testing	testing	NOUN
admet-247	181	9	of	of	ADP
admet-247	181	10	chemicals	chemical	NOUN
admet-247	181	11	,	,	PUNCT
admet-247	181	12	section	section	NOUN
admet-247	181	13	4	4	NUM
admet-247	181	14	,	,	PUNCT
admet-247	181	15	test	test	NOUN
admet-247	181	16	no	no	NOUN
admet-247	181	17	.	.	PUNCT
admet-247	182	1	428	428	NUM
admet-247	182	2	:	:	PUNCT
admet-247	182	3	skin	skin	NOUN
admet-247	182	4	absorption	absorption	NOUN
admet-247	182	5	:	:	PUNCT
admet-247	182	6	in	in	ADP
admet-247	182	7	vitro	vitro	X
admet-247	182	8	method	method	NOUN
admet-247	182	9	,	,	PUNCT
admet-247	182	10	oecd	oecd	PROPN
admet-247	182	11	publishing	publishing	NOUN
admet-247	182	12	,	,	PUNCT
admet-247	182	13	paris	paris	PROPN
admet-247	182	14	,	,	PUNCT
admet-247	182	15	2004	2004	NUM
admet-247	182	16	,	,	PUNCT
admet-247	182	17	http://dx.doi.org/10.1787/9789264071087-en	http://dx.doi.org/10.1787/9789264071087-en	PROPN
admet-247	182	18	.	.	PUNCT
admet-247	183	1	[	[	X
admet-247	183	2	26	26	NUM
admet-247	183	3	]	]	PUNCT
admet-247	183	4	who	who	PRON
admet-247	183	5	.	.	PUNCT
admet-247	184	1	environmental	environmental	ADJ
admet-247	184	2	health	health	NOUN
admet-247	184	3	criteria	criterion	NOUN
admet-247	184	4	(	(	PUNCT
admet-247	184	5	ehc	ehc	PROPN
admet-247	184	6	235	235	NUM
admet-247	184	7	)	)	PUNCT
admet-247	184	8	–	–	PUNCT
admet-247	184	9	dermal	dermal	ADJ
admet-247	184	10	absorption	absorption	NOUN
admet-247	184	11	.	.	PUNCT
admet-247	185	1	who	who	PRON
admet-247	185	2	press	press	VERB
admet-247	185	3	,	,	PUNCT
admet-247	185	4	geneva	geneva	PROPN
admet-247	185	5	,	,	PUNCT
admet-247	185	6	switzerland	switzerland	PROPN
admet-247	185	7	,	,	PUNCT
admet-247	185	8	2006	2006	NUM
admet-247	185	9	,	,	PUNCT
admet-247	185	10	http://www.who.int/ipcs/features/2006/ehc235/en/.	http://www.who.int/ipcs/features/2006/ehc235/en/.	PROPN
admet-247	185	11	[	[	X
admet-247	185	12	27	27	NUM
admet-247	185	13	]	]	X
admet-247	185	14	t.j	t.j	PROPN
admet-247	185	15	.	.	PROPN
admet-247	185	16	franz	franz	PROPN
admet-247	185	17	.	.	PUNCT
admet-247	186	1	journal	journal	NOUN
admet-247	186	2	of	of	ADP
admet-247	186	3	investigative	investigative	ADJ
admet-247	186	4	dermatology	dermatology	NOUN
admet-247	186	5	64	64	NUM
admet-247	186	6	(	(	PUNCT
admet-247	186	7	1975	1975	NUM
admet-247	186	8	)	)	PUNCT
admet-247	186	9	190–195	190–195	NUM
admet-247	186	10	.	.	PUNCT
admet-247	187	1	[	[	X
admet-247	187	2	28	28	NUM
admet-247	187	3	]	]	X
admet-247	187	4	h.	h.	PROPN
admet-247	187	5	wu	wu	PROPN
admet-247	187	6	,	,	PUNCT
admet-247	187	7	c.	c.	PROPN
admet-247	187	8	ramachandran	ramachandran	PROPN
admet-247	187	9	,	,	PUNCT
admet-247	187	10	n.d	n.d	PROPN
admet-247	187	11	.	.	PROPN
admet-247	187	12	weiner	weiner	NOUN
admet-247	187	13	,	,	PUNCT
admet-247	187	14	b.j	b.j	PROPN
admet-247	187	15	.	.	PROPN
admet-247	187	16	roessler	roessler	PROPN
admet-247	187	17	.	.	PUNCT
admet-247	188	1	international	international	ADJ
admet-247	188	2	journal	journal	PROPN
admet-247	188	3	of	of	ADP
admet-247	188	4	pharmaceutics	pharmaceutic	NOUN
admet-247	188	5	220	220	NUM
admet-247	188	6	(	(	PUNCT
admet-247	188	7	2001	2001	NUM
admet-247	188	8	)	)	PUNCT
admet-247	188	9	63–75	63–75	NUM
admet-247	188	10	.	.	PUNCT
admet-247	189	1	[	[	X
admet-247	189	2	29	29	NUM
admet-247	189	3	]	]	X
admet-247	189	4	n.	n.	NOUN
admet-247	189	5	akhtar	akhtar	PROPN
admet-247	189	6	,	,	PUNCT
admet-247	189	7	m.u	m.u	PROPN
admet-247	189	8	.	.	PROPN
admet-247	189	9	rehman	rehman	PROPN
admet-247	189	10	,	,	PUNCT
admet-247	189	11	h.m.s	h.m.	NOUN
admet-247	189	12	.	.	PUNCT
admet-247	190	1	khan	khan	PROPN
admet-247	190	2	,	,	PUNCT
admet-247	190	3	f.	f.	PROPN
admet-247	190	4	rasool	rasool	PROPN
admet-247	190	5	,	,	PUNCT
admet-247	190	6	t.	t.	PROPN
admet-247	190	7	saeed	saeed	PROPN
admet-247	190	8	,	,	PUNCT
admet-247	190	9	g.	g.	PROPN
admet-247	190	10	murtaza	murtaza	PROPN
admet-247	190	11	.	.	PUNCT
admet-247	191	1	tropical	tropical	ADJ
admet-247	191	2	journal	journal	PROPN
admet-247	191	3	of	of	ADP
admet-247	191	4	pharmaceutical	pharmaceutical	ADJ
admet-247	191	5	research	research	NOUN
admet-247	191	6	10	10	NUM
admet-247	191	7	(	(	PUNCT
admet-247	191	8	2011	2011	NUM
admet-247	191	9	)	)	PUNCT
admet-247	191	10	281–288	281–288	NUM
admet-247	191	11	.	.	PUNCT
admet-247	192	1	[	[	X
admet-247	192	2	30	30	NUM
admet-247	192	3	]	]	X
admet-247	192	4	l.	l.	PROPN
admet-247	192	5	panigrahi	panigrahi	PROPN
admet-247	192	6	,	,	PUNCT
admet-247	192	7	s.	s.	PROPN
admet-247	192	8	pattnaik	pattnaik	PROPN
admet-247	192	9	,	,	PUNCT
admet-247	192	10	s.k	s.k	PROPN
admet-247	192	11	.	.	PROPN
admet-247	192	12	ghosal	ghosal	PROPN
admet-247	192	13	.	.	PUNCT
admet-247	193	1	aaps	aap	NOUN
admet-247	193	2	pharmscitech	pharmscitech	VERB
admet-247	193	3	6	6	NUM
admet-247	193	4	(	(	PUNCT
admet-247	193	5	2005	2005	NUM
admet-247	193	6	)	)	PUNCT
admet-247	193	7	,	,	PUNCT
admet-247	193	8	article	article	NOUN
admet-247	193	9	25	25	NUM
admet-247	193	10	,	,	PUNCT
admet-247	193	11	e167	e167	NUM
admet-247	193	12	–	–	PUNCT
admet-247	193	13	e173	e173	NUM
admet-247	193	14	.	.	PUNCT
admet-247	194	1	[	[	X
admet-247	194	2	31	31	NUM
admet-247	194	3	]	]	X
admet-247	194	4	c.t	c.t	PROPN
admet-247	194	5	.	.	PROPN
admet-247	194	6	huang	huang	PROPN
admet-247	194	7	,	,	PUNCT
admet-247	194	8	m.j	m.j	PROPN
admet-247	194	9	.	.	PROPN
admet-247	194	10	tsai	tsai	PROPN
admet-247	194	11	,	,	PUNCT
admet-247	194	12	y.h	y.h	PROPN
admet-247	194	13	.	.	PROPN
admet-247	194	14	lin	lin	PROPN
admet-247	194	15	,	,	PUNCT
admet-247	194	16	y.s	y.s	PROPN
admet-247	194	17	.	.	PROPN
admet-247	194	18	fu	fu	PROPN
admet-247	194	19	,	,	PUNCT
admet-247	194	20	y.b	y.b	PROPN
admet-247	194	21	.	.	PROPN
admet-247	194	22	huang	huang	PROPN
admet-247	194	23	,	,	PUNCT
admet-247	194	24	y.h	y.h	PROPN
admet-247	194	25	.	.	PROPN
admet-247	194	26	tsai	tsai	PROPN
admet-247	194	27	,	,	PUNCT
admet-247	194	28	p.c	p.c	PROPN
admet-247	194	29	.	.	PROPN
admet-247	194	30	wu	wu	PROPN
admet-247	194	31	.	.	PUNCT
admet-247	195	1	international	international	ADJ
admet-247	195	2	journal	journal	PROPN
admet-247	195	3	of	of	ADP
admet-247	195	4	nanomedicine	nanomedicine	PROPN
admet-247	195	5	2013	2013	NUM
admet-247	195	6	(	(	PUNCT
admet-247	195	7	2013	2013	NUM
admet-247	195	8	)	)	PUNCT
admet-247	195	9	2295–2304	2295–2304	NUM
admet-247	195	10	.	.	PUNCT
admet-247	196	1	[	[	X
admet-247	196	2	32	32	NUM
admet-247	196	3	]	]	X
admet-247	196	4	y.s	y.s	PROPN
admet-247	196	5	.	.	PROPN
admet-247	196	6	rhee	rhee	PROPN
admet-247	196	7	,	,	PUNCT
admet-247	196	8	j.g	j.g	PROPN
admet-247	196	9	.	.	PROPN
admet-247	196	10	choi	choi	PROPN
admet-247	196	11	,	,	PUNCT
admet-247	196	12	e.s	e.s	PROPN
admet-247	196	13	.	.	PROPN
admet-247	196	14	park	park	PROPN
admet-247	196	15	,	,	PUNCT
admet-247	196	16	s.c	s.c	PROPN
admet-247	196	17	.	.	PROPN
admet-247	196	18	chi	chi	PROPN
admet-247	196	19	.	.	PUNCT
admet-247	197	1	international	international	ADJ
admet-247	197	2	journal	journal	PROPN
admet-247	197	3	of	of	ADP
admet-247	197	4	pharmaceutics	pharmaceutic	NOUN
admet-247	197	5	228	228	NUM
admet-247	197	6	(	(	PUNCT
admet-247	197	7	2001	2001	NUM
admet-247	197	8	)	)	PUNCT
admet-247	197	9	161–170	161–170	NUM
admet-247	197	10	.	.	PUNCT
admet-247	198	1	[	[	X
admet-247	198	2	33	33	NUM
admet-247	198	3	]	]	X
admet-247	198	4	s.a	s.a	PROPN
admet-247	198	5	.	.	PROPN
admet-247	198	6	ibrahim	ibrahim	PROPN
admet-247	198	7	,	,	PUNCT
admet-247	198	8	s.k	s.k	PROPN
admet-247	198	9	.	.	PROPN
admet-247	198	10	li	li	PROPN
admet-247	198	11	.	.	PROPN
admet-247	198	12	journal	journal	PROPN
admet-247	198	13	of	of	ADP
admet-247	198	14	controlled	control	VERB
admet-247	198	15	release	release	NOUN
admet-247	198	16	136	136	NUM
admet-247	198	17	(	(	PUNCT
admet-247	198	18	2009	2009	NUM
admet-247	198	19	)	)	PUNCT
admet-247	198	20	117–124	117–124	NUM
admet-247	198	21	.	.	PUNCT
admet-247	199	1	[	[	X
admet-247	199	2	34	34	NUM
admet-247	199	3	]	]	X
admet-247	199	4	u.	u.	PROPN
admet-247	199	5	jacobi	jacobi	PROPN
admet-247	199	6	,	,	PUNCT
admet-247	199	7	m.	m.	PROPN
admet-247	199	8	kaiser	kaiser	PROPN
admet-247	199	9	,	,	PUNCT
admet-247	199	10	r.	r.	PROPN
admet-247	199	11	toll	toll	PROPN
admet-247	199	12	,	,	PUNCT
admet-247	199	13	s.	s.	PROPN
admet-247	199	14	mangelsdorf	mangelsdorf	PROPN
admet-247	199	15	,	,	PUNCT
admet-247	199	16	h.	h.	PROPN
admet-247	199	17	audring	audring	PROPN
admet-247	199	18	,	,	PUNCT
admet-247	199	19	n.	n.	PROPN
admet-247	199	20	otberg	otberg	PROPN
admet-247	199	21	,	,	PUNCT
admet-247	199	22	w.	w.	PROPN
admet-247	199	23	sterry	sterry	PROPN
admet-247	199	24	,	,	PUNCT
admet-247	199	25	j.	j.	PROPN
admet-247	199	26	lademann	lademann	PROPN
admet-247	199	27	.	.	PUNCT
admet-247	200	1	skin	skin	NOUN
admet-247	200	2	research	research	NOUN
admet-247	200	3	and	and	CCONJ
admet-247	200	4	technology	technology	NOUN
admet-247	200	5	13	13	NUM
admet-247	200	6	(	(	PUNCT
admet-247	200	7	2007	2007	NUM
admet-247	200	8	)	)	PUNCT
admet-247	200	9	19–24	19–24	NUM
admet-247	200	10	.	.	PUNCT
admet-247	201	1	[	[	X
admet-247	201	2	35	35	NUM
admet-247	201	3	]	]	X
admet-247	201	4	c.	c.	PROPN
admet-247	201	5	herkenne	herkenne	PROPN
admet-247	201	6	,	,	PUNCT
admet-247	201	7	a.	a.	PROPN
admet-247	201	8	naik	naik	PROPN
admet-247	201	9	,	,	PUNCT
admet-247	201	10	y.n	y.n	PROPN
admet-247	201	11	.	.	PROPN
admet-247	201	12	kalia	kalia	PROPN
admet-247	201	13	,	,	PUNCT
admet-247	201	14	j.	j.	PROPN
admet-247	201	15	hadgraft	hadgraft	PROPN
admet-247	201	16	,	,	PUNCT
admet-247	201	17	r.h	r.h	PROPN
admet-247	201	18	.	.	PROPN
admet-247	201	19	guy	guy	NOUN
admet-247	201	20	.	.	PUNCT
admet-247	201	21	pharmaceutical	pharmaceutical	PROPN
admet-247	201	22	research	research	NOUN
admet-247	201	23	23	23	NUM
admet-247	201	24	(	(	PUNCT
admet-247	201	25	2006	2006	NUM
admet-247	201	26	)	)	PUNCT
admet-247	201	27	1850	1850	NUM
admet-247	201	28	-	-	SYM
admet-247	201	29	1856	1856	NUM
admet-247	201	30	.	.	PUNCT
admet-247	202	1	[	[	X
admet-247	202	2	36	36	NUM
admet-247	202	3	]	]	X
admet-247	202	4	w.	w.	PROPN
admet-247	202	5	meyer	meyer	PROPN
admet-247	202	6	,	,	PUNCT
admet-247	202	7	k.	k.	PROPN
admet-247	202	8	schwarz	schwarz	PROPN
admet-247	202	9	,	,	PUNCT
admet-247	202	10	k.t	k.t	PROPN
admet-247	202	11	.	.	PROPN
admet-247	202	12	neurand	neurand	PROPN
admet-247	202	13	.	.	PUNCT
admet-247	203	1	current	current	ADJ
admet-247	203	2	problems	problem	NOUN
admet-247	203	3	in	in	ADP
admet-247	203	4	dermatology	dermatology	NOUN
admet-247	203	5	7	7	NUM
admet-247	203	6	(	(	PUNCT
admet-247	203	7	1978	1978	NUM
admet-247	203	8	)	)	PUNCT
admet-247	203	9	39–52	39–52	NUM
admet-247	203	10	.	.	PUNCT
admet-247	204	1	[	[	X
admet-247	204	2	37	37	NUM
admet-247	204	3	]	]	X
admet-247	204	4	m.a	m.a	PROPN
admet-247	204	5	.	.	PROPN
admet-247	204	6	yamane	yamane	PROPN
admet-247	204	7	,	,	PUNCT
admet-247	204	8	a.c	a.c	PROPN
admet-247	204	9	.	.	PROPN
admet-247	204	10	williams	williams	PROPN
admet-247	204	11	,	,	PUNCT
admet-247	204	12	b.w	b.w	PROPN
admet-247	204	13	.	.	PROPN
admet-247	204	14	barry	barry	PROPN
admet-247	204	15	.	.	PUNCT
admet-247	205	1	journal	journal	PROPN
admet-247	205	2	of	of	ADP
admet-247	205	3	pharmacy	pharmacy	NOUN
admet-247	205	4	and	and	CCONJ
admet-247	205	5	pharmacology	pharmacology	NOUN
admet-247	205	6	47	47	NUM
admet-247	205	7	(	(	PUNCT
admet-247	205	8	1995	1995	NUM
admet-247	205	9	)	)	PUNCT
admet-247	205	10	978–989	978–989	NUM
admet-247	205	11	.	.	PUNCT
admet-247	206	1	[	[	X
admet-247	206	2	38	38	NUM
admet-247	206	3	]	]	X
admet-247	206	4	a.c	a.c	PROPN
admet-247	206	5	.	.	PROPN
admet-247	206	6	williams	williams	PROPN
admet-247	206	7	,	,	PUNCT
admet-247	206	8	b.w	b.w	PROPN
admet-247	206	9	.	.	PROPN
admet-247	206	10	barry	barry	PROPN
admet-247	206	11	.	.	PUNCT
admet-247	207	1	international	international	ADJ
admet-247	207	2	journal	journal	PROPN
admet-247	207	3	of	of	ADP
admet-247	207	4	pharmaceutics	pharmaceutic	NOUN
admet-247	207	5	56	56	NUM
admet-247	207	6	(	(	PUNCT
admet-247	207	7	1989	1989	NUM
admet-247	207	8	)	)	PUNCT
admet-247	207	9	43–50	43–50	NOUN
admet-247	207	10	.	.	PUNCT
admet-247	208	1	[	[	X
admet-247	208	2	39	39	NUM
admet-247	208	3	]	]	PUNCT
admet-247	208	4	a.c	a.c	PROPN
admet-247	208	5	.	.	PROPN
admet-247	208	6	williams	williams	PROPN
admet-247	208	7	,	,	PUNCT
admet-247	208	8	b.w	b.w	PROPN
admet-247	208	9	.	.	PROPN
admet-247	208	10	barry	barry	PROPN
admet-247	208	11	.	.	PUNCT
admet-247	209	1	advanced	advanced	ADJ
admet-247	209	2	drug	drug	NOUN
admet-247	209	3	delivery	delivery	NOUN
admet-247	209	4	reviews	review	VERB
admet-247	209	5	56	56	NUM
admet-247	209	6	(	(	PUNCT
admet-247	209	7	2004	2004	NUM
admet-247	209	8	)	)	PUNCT
admet-247	210	1	603–618	603–618	NUM
admet-247	210	2	.	.	PUNCT
admet-247	211	1	[	[	X
admet-247	211	2	40	40	NUM
admet-247	211	3	]	]	X
admet-247	211	4	h.	h.	PROPN
admet-247	211	5	trommer	trommer	PROPN
admet-247	211	6	,	,	PUNCT
admet-247	211	7	r.h.h	r.h.h	NOUN
admet-247	211	8	.	.	PUNCT
admet-247	212	1	neubert	neubert	PROPN
admet-247	212	2	.	.	PUNCT
admet-247	213	1	skin	skin	NOUN
admet-247	213	2	pharmacology	pharmacology	NOUN
admet-247	213	3	and	and	CCONJ
admet-247	213	4	physiology	physiology	NOUN
admet-247	213	5	19	19	NUM
admet-247	213	6	(	(	PUNCT
admet-247	213	7	2006	2006	NUM
admet-247	213	8	)	)	PUNCT
admet-247	213	9	106–121	106–121	NUM
admet-247	213	10	.	.	PUNCT
admet-247	214	1	[	[	X
admet-247	214	2	41	41	NUM
admet-247	214	3	]	]	X
admet-247	214	4	b.w	b.w	PROPN
admet-247	214	5	.	.	PROPN
admet-247	214	6	barry	barry	PROPN
admet-247	214	7	.	.	PUNCT
admet-247	215	1	journal	journal	PROPN
admet-247	215	2	of	of	ADP
admet-247	215	3	control	control	NOUN
admet-247	215	4	release	release	NOUN
admet-247	215	5	6	6	NUM
admet-247	215	6	(	(	PUNCT
admet-247	215	7	1987	1987	NUM
admet-247	215	8	)	)	PUNCT
admet-247	215	9	85–97	85–97	NOUN
admet-247	215	10	.	.	PUNCT
admet-247	216	1	©	©	PROPN
admet-247	216	2	2015	2015	NUM
admet-247	216	3	by	by	ADP
admet-247	216	4	the	the	DET
admet-247	216	5	authors	author	NOUN
admet-247	216	6	;	;	PUNCT
admet-247	216	7	licensee	licensee	PROPN
admet-247	216	8	iapc	iapc	PROPN
admet-247	216	9	,	,	PUNCT
admet-247	216	10	zagreb	zagreb	PROPN
admet-247	216	11	,	,	PUNCT
admet-247	216	12	croatia	croatia	PROPN
admet-247	216	13	.	.	PUNCT
admet-247	217	1	this	this	DET
admet-247	217	2	article	article	NOUN
admet-247	217	3	is	be	AUX
admet-247	217	4	an	an	DET
admet-247	217	5	open	open	ADJ
admet-247	217	6	-	-	PUNCT
admet-247	217	7	access	access	NOUN
admet-247	217	8	article	article	NOUN
admet-247	217	9	distributed	distribute	VERB
admet-247	217	10	under	under	ADP
admet-247	217	11	the	the	DET
admet-247	217	12	terms	term	NOUN
admet-247	217	13	and	and	CCONJ
admet-247	217	14	conditions	condition	NOUN
admet-247	217	15	of	of	ADP
admet-247	217	16	the	the	DET
admet-247	217	17	creative	creative	ADJ
admet-247	217	18	commons	common	NOUN
admet-247	217	19	attribution	attribution	NOUN
admet-247	217	20	license	license	NOUN
admet-247	217	21	(	(	PUNCT
admet-247	217	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-247	217	23	)	)	PUNCT
admet-247	217	24	http://www.drugbank.ca/drugs/db00328	http://www.drugbank.ca/drugs/db00328	PROPN
admet-247	217	25	http://mmsl.cz/vicms/soubory/pdf/mmsl_2014_1_6__www.pdf	http://mmsl.cz/vicms/soubory/pdf/mmsl_2014_1_6__www.pdf	PROPN
admet-247	217	26	http://dx.doi.org/10.1787/9789264071087-en	http://dx.doi.org/10.1787/9789264071087-en	PROPN
admet-247	217	27	http://www.who.int/ipcs/features/2006/ehc235/en/	http://www.who.int/ipcs/features/2006/ehc235/en/	NOUN
admet-247	217	28	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN