id	sid	tid	token	lemma	pos
admet-257	1	1	manuscript	manuscript	PROPN
admet-257	1	2	doi	doi	PROPN
admet-257	1	3	:	:	PUNCT
admet-257	1	4	10.5599	10.5599	NUM
admet-257	1	5	/	/	SYM
admet-257	1	6	admet.3.4.257	admet.3.4.257	NUM
admet-257	1	7	363	363	NUM
admet-257	1	8	admet	admet	X
admet-257	1	9	&	&	CCONJ
admet-257	1	10	dmpk	dmpk	PROPN
admet-257	1	11	3(4	3(4	NUM
admet-257	1	12	)	)	PUNCT
admet-257	1	13	(	(	PUNCT
admet-257	1	14	2015	2015	NUM
admet-257	1	15	)	)	PUNCT
admet-257	1	16	363	363	NUM
admet-257	1	17	-	-	SYM
admet-257	1	18	365	365	NUM
admet-257	1	19	;	;	PUNCT
admet-257	1	20	doi	doi	NOUN
admet-257	1	21	:	:	PUNCT
admet-257	1	22	10.5599	10.5599	NUM
admet-257	1	23	/	/	SYM
admet-257	1	24	admet.3.4.257	admet.3.4.257	VERB
admet-257	1	25	open	open	ADJ
admet-257	1	26	access	access	NOUN
admet-257	1	27	:	:	PUNCT
admet-257	1	28	issn	issn	PROPN
admet-257	1	29	:	:	PUNCT
admet-257	1	30	1848	1848	NUM
admet-257	1	31	-	-	SYM
admet-257	1	32	7718	7718	NUM
admet-257	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-257	1	34	opinion	opinion	NOUN
admet-257	1	35	ethical	ethical	ADJ
admet-257	1	36	considerations	consideration	NOUN
admet-257	1	37	of	of	ADP
admet-257	1	38	preclinical	preclinical	ADJ
admet-257	1	39	testing	testing	NOUN
admet-257	1	40	allen	allen	PROPN
admet-257	1	41	goldenthal	goldenthal	PROPN
admet-257	1	42	*	*	PROPN
admet-257	1	43	faculty	faculty	NOUN
admet-257	1	44	of	of	ADP
admet-257	1	45	health	health	NOUN
admet-257	1	46	sciences	sciences	PROPN
admet-257	1	47	,	,	PUNCT
admet-257	1	48	university	university	NOUN
admet-257	1	49	of	of	ADP
admet-257	1	50	macau	macau	PROPN
admet-257	1	51	,	,	PUNCT
admet-257	1	52	taipa	taipa	PROPN
admet-257	1	53	,	,	PUNCT
admet-257	1	54	macau	macau	NOUN
admet-257	1	55	*	*	PUNCT
admet-257	1	56	corresponding	correspond	VERB
admet-257	1	57	author	author	NOUN
admet-257	1	58	:	:	PUNCT
admet-257	1	59	e	e	NOUN
admet-257	1	60	-	-	NOUN
admet-257	1	61	mail	mail	NOUN
admet-257	1	62	:	:	PUNCT
admet-257	1	63	aegoldenthal@umac.mo	aegoldenthal@umac.mo	PROPN
admet-257	1	64	;	;	PUNCT
admet-257	1	65	tel	tel	PROPN
admet-257	1	66	.	.	PUNCT
admet-257	1	67	:	:	PUNCT
admet-257	2	1	+853	+853	NUM
admet-257	2	2	-	-	PUNCT
admet-257	2	3	623	623	NUM
admet-257	2	4	-	-	PUNCT
admet-257	2	5	75280	75280	NUM
admet-257	2	6	received	receive	VERB
admet-257	2	7	:	:	PUNCT
admet-257	2	8	november	november	PROPN
admet-257	2	9	17	17	NUM
admet-257	2	10	,	,	PUNCT
admet-257	2	11	2015	2015	NUM
admet-257	2	12	;	;	PUNCT
admet-257	2	13	revised	revise	VERB
admet-257	2	14	:	:	PUNCT
admet-257	2	15	december	december	PROPN
admet-257	2	16	02	02	NUM
admet-257	2	17	,	,	PUNCT
admet-257	2	18	2015	2015	NUM
admet-257	2	19	;	;	PUNCT
admet-257	2	20	published	publish	VERB
admet-257	2	21	:	:	PUNCT
admet-257	2	22	december	december	PROPN
admet-257	2	23	30	30	NUM
admet-257	2	24	,	,	PUNCT
admet-257	2	25	2015	2015	NUM
admet-257	2	26	abstract	abstract	NOUN
admet-257	2	27	the	the	DET
admet-257	2	28	numbers	number	NOUN
admet-257	2	29	of	of	ADP
admet-257	2	30	animal	animal	NOUN
admet-257	2	31	tests	test	NOUN
admet-257	2	32	being	be	AUX
admet-257	2	33	conducted	conduct	VERB
admet-257	2	34	are	be	AUX
admet-257	2	35	on	on	ADP
admet-257	2	36	a	a	DET
admet-257	2	37	sharp	sharp	ADJ
admet-257	2	38	incline	incline	NOUN
admet-257	2	39	.	.	PUNCT
admet-257	3	1	much	much	ADJ
admet-257	3	2	of	of	ADP
admet-257	3	3	this	this	DET
admet-257	3	4	increase	increase	NOUN
admet-257	3	5	is	be	AUX
admet-257	3	6	directly	directly	ADV
admet-257	3	7	due	due	ADJ
admet-257	3	8	to	to	ADP
admet-257	3	9	our	our	PRON
admet-257	3	10	ability	ability	NOUN
admet-257	3	11	to	to	PART
admet-257	3	12	generate	generate	VERB
admet-257	3	13	transgenic	transgenic	NOUN
admet-257	3	14	models	model	NOUN
admet-257	3	15	and	and	CCONJ
admet-257	3	16	knock	knock	NOUN
admet-257	3	17	-	-	PUNCT
admet-257	3	18	outs	out	NOUN
admet-257	3	19	,	,	PUNCT
admet-257	3	20	thereby	thereby	ADV
admet-257	3	21	increasing	increase	VERB
admet-257	3	22	the	the	DET
admet-257	3	23	validity	validity	NOUN
admet-257	3	24	of	of	ADP
admet-257	3	25	the	the	DET
admet-257	3	26	animal	animal	NOUN
admet-257	3	27	model	model	NOUN
admet-257	3	28	but	but	CCONJ
admet-257	3	29	not	not	PART
admet-257	3	30	necessarily	necessarily	ADV
admet-257	3	31	correlating	correlate	VERB
admet-257	3	32	directly	directly	ADV
admet-257	3	33	with	with	ADP
admet-257	3	34	any	any	DET
admet-257	3	35	translational	translational	ADJ
admet-257	3	36	medical	medical	ADJ
admet-257	3	37	benefits	benefit	NOUN
admet-257	3	38	to	to	ADP
admet-257	3	39	the	the	DET
admet-257	3	40	human	human	ADJ
admet-257	3	41	counterpart	counterpart	NOUN
admet-257	3	42	.	.	PUNCT
admet-257	4	1	in	in	ADP
admet-257	4	2	spite	spite	NOUN
admet-257	4	3	of	of	ADP
admet-257	4	4	our	our	PRON
admet-257	4	5	best	good	ADJ
admet-257	4	6	efforts	effort	NOUN
admet-257	4	7	,	,	PUNCT
admet-257	4	8	there	there	PRON
admet-257	4	9	still	still	ADV
admet-257	4	10	exist	exist	VERB
admet-257	4	11	species	specie	NOUN
admet-257	4	12	differences	difference	NOUN
admet-257	4	13	that	that	PRON
admet-257	4	14	prevent	prevent	VERB
admet-257	4	15	the	the	DET
admet-257	4	16	application	application	NOUN
admet-257	4	17	directly	directly	ADV
admet-257	4	18	from	from	ADP
admet-257	4	19	animal	animal	NOUN
admet-257	4	20	to	to	ADP
admet-257	4	21	human	human	NOUN
admet-257	4	22	,	,	PUNCT
admet-257	4	23	and	and	CCONJ
admet-257	4	24	in	in	ADP
admet-257	4	25	some	some	DET
admet-257	4	26	examples	example	NOUN
admet-257	4	27	having	have	VERB
admet-257	4	28	a	a	DET
admet-257	4	29	completely	completely	ADV
admet-257	4	30	different	different	ADJ
admet-257	4	31	and	and	CCONJ
admet-257	4	32	adverse	adverse	ADJ
admet-257	4	33	effect	effect	NOUN
admet-257	4	34	from	from	ADP
admet-257	4	35	that	that	PRON
admet-257	4	36	seen	see	VERB
admet-257	4	37	in	in	ADP
admet-257	4	38	the	the	DET
admet-257	4	39	animal	animal	NOUN
admet-257	4	40	model	model	NOUN
admet-257	4	41	.	.	PUNCT
admet-257	5	1	there	there	PRON
admet-257	5	2	are	be	VERB
admet-257	5	3	several	several	ADJ
admet-257	5	4	ways	way	NOUN
admet-257	5	5	in	in	ADP
admet-257	5	6	which	which	PRON
admet-257	5	7	we	we	PRON
admet-257	5	8	can	can	AUX
admet-257	5	9	improve	improve	VERB
admet-257	5	10	the	the	DET
admet-257	5	11	opportunity	opportunity	NOUN
admet-257	5	12	for	for	ADP
admet-257	5	13	a	a	DET
admet-257	5	14	positive	positive	ADJ
admet-257	5	15	test	test	NOUN
admet-257	5	16	outcome	outcome	NOUN
admet-257	5	17	and	and	CCONJ
admet-257	5	18	at	at	ADP
admet-257	5	19	the	the	DET
admet-257	5	20	same	same	ADJ
admet-257	5	21	time	time	NOUN
admet-257	5	22	reduce	reduce	VERB
admet-257	5	23	the	the	DET
admet-257	5	24	animal	animal	NOUN
admet-257	5	25	usage	usage	NOUN
admet-257	5	26	which	which	PRON
admet-257	5	27	is	be	AUX
admet-257	5	28	associated	associate	VERB
admet-257	5	29	with	with	ADP
admet-257	5	30	our	our	PRON
admet-257	5	31	current	current	ADJ
admet-257	5	32	animal	animal	NOUN
admet-257	5	33	testing	testing	NOUN
admet-257	5	34	practices	practice	NOUN
admet-257	5	35	.	.	PUNCT
admet-257	6	1	the	the	DET
admet-257	6	2	benefit	benefit	NOUN
admet-257	6	3	of	of	ADP
admet-257	6	4	the	the	DET
admet-257	6	5	3r	3r	NOUN
admet-257	6	6	’s	’s	PART
admet-257	6	7	is	be	AUX
admet-257	6	8	that	that	SCONJ
admet-257	6	9	they	they	PRON
admet-257	6	10	encourage	encourage	VERB
admet-257	6	11	us	we	PRON
admet-257	6	12	not	not	PART
admet-257	6	13	only	only	ADV
admet-257	6	14	to	to	PART
admet-257	6	15	avoid	avoid	VERB
admet-257	6	16	wastage	wastage	NOUN
admet-257	6	17	of	of	ADP
admet-257	6	18	life	life	NOUN
admet-257	6	19	but	but	CCONJ
admet-257	6	20	that	that	SCONJ
admet-257	6	21	they	they	PRON
admet-257	6	22	require	require	VERB
admet-257	6	23	us	we	PRON
admet-257	6	24	to	to	PART
admet-257	6	25	provide	provide	VERB
admet-257	6	26	considerable	considerable	ADJ
admet-257	6	27	foresight	foresight	NOUN
admet-257	6	28	and	and	CCONJ
admet-257	6	29	extrapolated	extrapolate	VERB
admet-257	6	30	thought	think	VERB
admet-257	6	31	before	before	ADP
admet-257	6	32	directly	directly	ADV
admet-257	6	33	engaging	engage	VERB
admet-257	6	34	in	in	ADP
admet-257	6	35	the	the	DET
admet-257	6	36	preclinical	preclinical	ADJ
admet-257	6	37	testing	testing	NOUN
admet-257	6	38	phase	phase	NOUN
admet-257	6	39	.	.	PUNCT
admet-257	7	1	keywords	keyword	VERB
admet-257	7	2	animal	animal	NOUN
admet-257	7	3	models	model	NOUN
admet-257	7	4	;	;	PUNCT
admet-257	7	5	in	in	ADP
admet-257	7	6	vivo	vivo	NOUN
admet-257	7	7	;	;	PUNCT
admet-257	7	8	regulatory	regulatory	ADJ
admet-257	7	9	;	;	PUNCT
admet-257	7	10	pharmaceuticals	pharmaceutical	NOUN
admet-257	7	11	;	;	PUNCT
admet-257	7	12	ethics	ethic	NOUN
admet-257	7	13	introduction	introduction	NOUN
admet-257	7	14	it	it	PRON
admet-257	7	15	has	have	AUX
admet-257	7	16	been	be	AUX
admet-257	7	17	estimated	estimate	VERB
admet-257	7	18	that	that	SCONJ
admet-257	7	19	of	of	ADP
admet-257	7	20	every	every	DET
admet-257	7	21	5000	5000	NUM
admet-257	7	22	new	new	ADJ
admet-257	7	23	drug	drug	NOUN
admet-257	7	24	development	development	NOUN
admet-257	7	25	projects	project	NOUN
admet-257	7	26	that	that	PRON
admet-257	7	27	make	make	VERB
admet-257	7	28	it	it	PRON
admet-257	7	29	through	through	ADP
admet-257	7	30	initial	initial	ADJ
admet-257	7	31	computer	computer	NOUN
admet-257	7	32	modelling	modelling	NOUN
admet-257	7	33	and	and	CCONJ
admet-257	7	34	in	in	ADP
admet-257	7	35	-	-	PUNCT
admet-257	7	36	vitro	vitro	X
admet-257	7	37	testing	testing	NOUN
admet-257	7	38	,	,	PUNCT
admet-257	7	39	only	only	ADV
admet-257	7	40	5	5	NUM
admet-257	7	41	will	will	AUX
admet-257	7	42	ever	ever	ADV
admet-257	7	43	successfully	successfully	ADV
admet-257	7	44	pass	pass	VERB
admet-257	7	45	preclinical	preclinical	ADJ
admet-257	7	46	tests	test	NOUN
admet-257	7	47	which	which	PRON
admet-257	7	48	are	be	AUX
admet-257	7	49	mandatory	mandatory	ADJ
admet-257	7	50	before	before	ADP
admet-257	7	51	clinical	clinical	ADJ
admet-257	7	52	testing	testing	NOUN
admet-257	7	53	in	in	ADP
admet-257	7	54	humans	human	NOUN
admet-257	7	55	.	.	PUNCT
admet-257	8	1	moreover	moreover	ADV
admet-257	8	2	,	,	PUNCT
admet-257	8	3	of	of	ADP
admet-257	8	4	those	those	DET
admet-257	8	5	drug	drug	NOUN
admet-257	8	6	developments	development	NOUN
admet-257	8	7	that	that	PRON
admet-257	8	8	successfully	successfully	ADV
admet-257	8	9	pass	pass	VERB
admet-257	8	10	the	the	DET
admet-257	8	11	preclinical	preclinical	ADJ
admet-257	8	12	testing	testing	NOUN
admet-257	8	13	phase	phase	NOUN
admet-257	8	14	,	,	PUNCT
admet-257	8	15	only	only	ADV
admet-257	8	16	5	5	NUM
admet-257	8	17	%	%	NOUN
admet-257	8	18	ever	ever	ADV
admet-257	8	19	make	make	VERB
admet-257	8	20	it	it	PRON
admet-257	8	21	to	to	ADP
admet-257	8	22	the	the	DET
admet-257	8	23	market	market	NOUN
admet-257	8	24	as	as	ADP
admet-257	8	25	a	a	DET
admet-257	8	26	licensed	licensed	ADJ
admet-257	8	27	treatment	treatment	NOUN
admet-257	8	28	for	for	ADP
admet-257	8	29	humans	human	NOUN
admet-257	8	30	.	.	PUNCT
admet-257	9	1	essentially	essentially	ADV
admet-257	9	2	,	,	PUNCT
admet-257	9	3	that	that	PRON
admet-257	9	4	suggests	suggest	VERB
admet-257	9	5	that	that	SCONJ
admet-257	9	6	there	there	PRON
admet-257	9	7	is	be	VERB
admet-257	9	8	less	less	ADJ
admet-257	9	9	than	than	ADP
admet-257	9	10	a	a	DET
admet-257	9	11	0.1	0.1	NUM
admet-257	9	12	%	%	NOUN
admet-257	9	13	chance	chance	NOUN
admet-257	9	14	of	of	ADP
admet-257	9	15	a	a	DET
admet-257	9	16	successful	successful	ADJ
admet-257	9	17	drug	drug	NOUN
admet-257	9	18	product	product	NOUN
admet-257	9	19	being	be	AUX
admet-257	9	20	developed	develop	VERB
admet-257	9	21	from	from	ADP
admet-257	9	22	inception	inception	NOUN
admet-257	9	23	to	to	ADP
admet-257	9	24	market	market	NOUN
admet-257	9	25	.	.	PUNCT
admet-257	10	1	although	although	SCONJ
admet-257	10	2	these	these	DET
admet-257	10	3	statistics	statistic	NOUN
admet-257	10	4	justify	justify	VERB
admet-257	10	5	why	why	SCONJ
admet-257	10	6	drug	drug	NOUN
admet-257	10	7	companies	company	NOUN
admet-257	10	8	must	must	AUX
admet-257	10	9	charge	charge	VERB
admet-257	10	10	accordingly	accordingly	ADV
admet-257	10	11	to	to	PART
admet-257	10	12	recover	recover	VERB
admet-257	10	13	their	their	PRON
admet-257	10	14	cost	cost	NOUN
admet-257	10	15	outputs	output	NOUN
admet-257	10	16	which	which	PRON
admet-257	10	17	includes	include	VERB
admet-257	10	18	all	all	DET
admet-257	10	19	the	the	DET
admet-257	10	20	costs	cost	NOUN
admet-257	10	21	of	of	ADP
admet-257	10	22	the	the	DET
admet-257	10	23	majority	majority	NOUN
admet-257	10	24	of	of	ADP
admet-257	10	25	failed	fail	VERB
admet-257	10	26	projects	project	NOUN
admet-257	10	27	,	,	PUNCT
admet-257	10	28	it	it	PRON
admet-257	10	29	can	can	AUX
admet-257	10	30	not	not	PART
admet-257	10	31	ethically	ethically	ADV
admet-257	10	32	justify	justify	VERB
admet-257	10	33	the	the	DET
admet-257	10	34	number	number	NOUN
admet-257	10	35	of	of	ADP
admet-257	10	36	animals	animal	NOUN
admet-257	10	37	that	that	PRON
admet-257	10	38	are	be	AUX
admet-257	10	39	sacrificed	sacrifice	VERB
admet-257	10	40	in	in	ADP
admet-257	10	41	order	order	NOUN
admet-257	10	42	to	to	PART
admet-257	10	43	achieve	achieve	VERB
admet-257	10	44	this	this	DET
admet-257	10	45	high	high	ADJ
admet-257	10	46	failure	failure	NOUN
admet-257	10	47	rate	rate	NOUN
admet-257	10	48	.	.	PUNCT
admet-257	11	1	there	there	PRON
admet-257	11	2	is	be	VERB
admet-257	11	3	this	this	DET
admet-257	11	4	vast	vast	ADJ
admet-257	11	5	chasm	chasm	NOUN
admet-257	11	6	between	between	ADP
admet-257	11	7	preclinical	preclinical	ADJ
admet-257	11	8	testing	testing	NOUN
admet-257	11	9	in	in	ADP
admet-257	11	10	animals	animal	NOUN
admet-257	11	11	and	and	CCONJ
admet-257	11	12	the	the	DET
admet-257	11	13	eventual	eventual	ADJ
admet-257	11	14	successful	successful	ADJ
admet-257	11	15	outcome	outcome	NOUN
admet-257	11	16	of	of	ADP
admet-257	11	17	clinical	clinical	ADJ
admet-257	11	18	trials	trial	NOUN
admet-257	11	19	in	in	ADP
admet-257	11	20	humans	human	NOUN
admet-257	11	21	into	into	ADP
admet-257	11	22	which	which	PRON
admet-257	11	23	the	the	DET
admet-257	11	24	majority	majority	NOUN
admet-257	11	25	of	of	ADP
admet-257	11	26	these	these	DET
admet-257	11	27	drug	drug	NOUN
admet-257	11	28	trials	trial	NOUN
admet-257	11	29	disappear	disappear	VERB
admet-257	11	30	.	.	PUNCT
admet-257	12	1	in	in	ADP
admet-257	12	2	order	order	NOUN
admet-257	12	3	to	to	PART
admet-257	12	4	compensate	compensate	VERB
admet-257	12	5	or	or	CCONJ
admet-257	12	6	reduce	reduce	VERB
admet-257	12	7	this	this	DET
admet-257	12	8	failure	failure	NOUN
admet-257	12	9	rate	rate	NOUN
admet-257	12	10	,	,	PUNCT
admet-257	12	11	additional	additional	ADJ
admet-257	12	12	safeguards	safeguard	NOUN
admet-257	12	13	must	must	AUX
admet-257	12	14	be	be	AUX
admet-257	12	15	placed	place	VERB
admet-257	12	16	on	on	ADP
admet-257	12	17	which	which	PRON
admet-257	12	18	drugs	drug	NOUN
admet-257	12	19	do	do	AUX
admet-257	12	20	make	make	VERB
admet-257	12	21	it	it	PRON
admet-257	12	22	to	to	ADP
admet-257	12	23	the	the	DET
admet-257	12	24	animal	animal	NOUN
admet-257	12	25	testing	testing	NOUN
admet-257	12	26	phase	phase	NOUN
admet-257	12	27	to	to	PART
admet-257	12	28	at	at	ADV
admet-257	12	29	least	least	ADJ
admet-257	12	30	ensure	ensure	VERB
admet-257	12	31	that	that	SCONJ
admet-257	12	32	the	the	DET
admet-257	12	33	percentage	percentage	NOUN
admet-257	12	34	of	of	ADP
admet-257	12	35	drugs	drug	NOUN
admet-257	12	36	successfully	successfully	ADV
admet-257	12	37	passing	pass	VERB
admet-257	12	38	preclinical	preclinical	ADJ
admet-257	12	39	trials	trial	NOUN
admet-257	12	40	is	be	AUX
admet-257	12	41	much	much	ADV
admet-257	12	42	higher	high	ADJ
admet-257	12	43	than	than	ADP
admet-257	12	44	the	the	DET
admet-257	12	45	current	current	ADJ
admet-257	12	46	0.1	0.1	NUM
admet-257	12	47	%	%	NOUN
admet-257	12	48	.	.	PUNCT
admet-257	13	1	we	we	PRON
admet-257	13	2	can	can	AUX
admet-257	13	3	not	not	PART
admet-257	13	4	do	do	VERB
admet-257	13	5	much	much	ADJ
admet-257	13	6	at	at	ADP
admet-257	13	7	our	our	PRON
admet-257	13	8	current	current	ADJ
admet-257	13	9	level	level	NOUN
admet-257	13	10	of	of	ADP
admet-257	13	11	testing	testing	NOUN
admet-257	13	12	and	and	CCONJ
admet-257	13	13	knowledge	knowledge	NOUN
admet-257	13	14	to	to	PART
admet-257	13	15	increase	increase	VERB
admet-257	13	16	the	the	DET
admet-257	13	17	translational	translational	ADJ
admet-257	13	18	level	level	NOUN
admet-257	13	19	of	of	ADP
admet-257	13	20	success	success	NOUN
admet-257	13	21	between	between	ADP
admet-257	13	22	animals	animal	NOUN
admet-257	13	23	and	and	CCONJ
admet-257	13	24	humans	human	NOUN
admet-257	13	25	,	,	PUNCT
admet-257	13	26	since	since	SCONJ
admet-257	13	27	that	that	PRON
admet-257	13	28	is	be	AUX
admet-257	13	29	still	still	ADV
admet-257	13	30	not	not	PART
admet-257	13	31	fully	fully	ADV
admet-257	13	32	understood	understand	VERB
admet-257	13	33	why	why	SCONJ
admet-257	13	34	a	a	DET
admet-257	13	35	drug	drug	NOUN
admet-257	13	36	is	be	AUX
admet-257	13	37	successful	successful	ADJ
admet-257	13	38	in	in	ADP
admet-257	13	39	one	one	NUM
admet-257	13	40	species	specie	NOUN
admet-257	13	41	and	and	CCONJ
admet-257	13	42	not	not	PART
admet-257	13	43	another	another	PRON
admet-257	13	44	,	,	PUNCT
admet-257	13	45	but	but	CCONJ
admet-257	13	46	we	we	PRON
admet-257	13	47	certainly	certainly	ADV
admet-257	13	48	can	can	AUX
admet-257	13	49	narrow	narrow	VERB
admet-257	13	50	the	the	DET
admet-257	13	51	gap	gap	NOUN
admet-257	13	52	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-257	13	53	mailto:aegoldenthal@umac.mo	mailto:aegoldenthal@umac.mo	PROPN
admet-257	13	54	allen	allen	PROPN
admet-257	13	55	goldenthtal	goldenthtal	PROPN
admet-257	13	56	admet	admet	PROPN
admet-257	13	57	&	&	CCONJ
admet-257	13	58	dmpk	dmpk	PROPN
admet-257	13	59	3(4	3(4	NUM
admet-257	13	60	)	)	PUNCT
admet-257	13	61	(	(	PUNCT
admet-257	13	62	2015	2015	NUM
admet-257	13	63	)	)	PUNCT
admet-257	13	64	363	363	NUM
admet-257	13	65	-	-	SYM
admet-257	13	66	365	365	NUM
admet-257	13	67	364	364	NUM
admet-257	13	68	between	between	ADP
admet-257	13	69	drugs	drug	NOUN
admet-257	13	70	that	that	PRON
admet-257	13	71	appear	appear	VERB
admet-257	13	72	to	to	PART
admet-257	13	73	have	have	VERB
admet-257	13	74	great	great	ADJ
admet-257	13	75	potential	potential	NOUN
admet-257	13	76	in	in	ADP
admet-257	13	77	the	the	DET
admet-257	13	78	computer	computer	NOUN
admet-257	13	79	modelling	modelling	NOUN
admet-257	13	80	and	and	CCONJ
admet-257	13	81	in	in	ADP
admet-257	13	82	-	-	PUNCT
admet-257	13	83	vitro	vitro	X
admet-257	13	84	stage	stage	NOUN
admet-257	13	85	,	,	PUNCT
admet-257	13	86	only	only	ADV
admet-257	13	87	to	to	PART
admet-257	13	88	fail	fail	VERB
admet-257	13	89	when	when	SCONJ
admet-257	13	90	they	they	PRON
admet-257	13	91	are	be	AUX
admet-257	13	92	introduced	introduce	VERB
admet-257	13	93	into	into	ADP
admet-257	13	94	animals	animal	NOUN
admet-257	13	95	.	.	PUNCT
admet-257	14	1	major	major	ADJ
admet-257	14	2	challenges	challenge	VERB
admet-257	14	3	the	the	DET
admet-257	14	4	issue	issue	NOUN
admet-257	14	5	with	with	ADP
admet-257	14	6	safety	safety	NOUN
admet-257	14	7	and	and	CCONJ
admet-257	14	8	toxicity	toxicity	NOUN
admet-257	14	9	testing	testing	NOUN
admet-257	14	10	in	in	ADP
admet-257	14	11	a	a	DET
admet-257	14	12	preclinical	preclinical	ADJ
admet-257	14	13	trial	trial	NOUN
admet-257	14	14	centres	centre	NOUN
admet-257	14	15	on	on	ADP
admet-257	14	16	dosage	dosage	NOUN
admet-257	14	17	.	.	PUNCT
admet-257	15	1	when	when	SCONJ
admet-257	15	2	examining	examine	VERB
admet-257	15	3	the	the	DET
admet-257	15	4	weight	weight	NOUN
admet-257	15	5	ratio	ratio	NOUN
admet-257	15	6	of	of	ADP
admet-257	15	7	a	a	DET
admet-257	15	8	mouse	mouse	NOUN
admet-257	15	9	at	at	ADP
admet-257	15	10	25	25	NUM
admet-257	15	11	g	g	NOUN
admet-257	15	12	versus	versus	ADP
admet-257	15	13	the	the	DET
admet-257	15	14	average	average	ADJ
admet-257	15	15	human	human	NOUN
admet-257	15	16	at	at	ADP
admet-257	15	17	60	60	NUM
admet-257	15	18	kg	kg	NOUN
admet-257	15	19	,	,	PUNCT
admet-257	15	20	then	then	ADV
admet-257	15	21	the	the	DET
admet-257	15	22	ratio	ratio	NOUN
admet-257	15	23	of	of	ADP
admet-257	15	24	1:2400	1:2400	NUM
admet-257	15	25	would	would	AUX
admet-257	15	26	suggest	suggest	VERB
admet-257	15	27	that	that	SCONJ
admet-257	15	28	we	we	PRON
admet-257	15	29	must	must	AUX
admet-257	15	30	administer	administer	VERB
admet-257	15	31	to	to	ADP
admet-257	15	32	the	the	DET
admet-257	15	33	mouse	mouse	PROPN
admet-257	15	34	1/2400	1/2400	NUM
admet-257	15	35	of	of	ADP
admet-257	15	36	the	the	DET
admet-257	15	37	anticipated	anticipate	VERB
admet-257	15	38	human	human	ADJ
admet-257	15	39	dose	dose	NOUN
admet-257	15	40	on	on	ADP
admet-257	15	41	a	a	DET
admet-257	15	42	dose	dose	NOUN
admet-257	15	43	/	/	SYM
admet-257	15	44	kg	kg	PROPN
admet-257	15	45	basis	basis	NOUN
admet-257	15	46	.	.	PUNCT
admet-257	16	1	this	this	PRON
admet-257	16	2	would	would	AUX
admet-257	16	3	require	require	VERB
admet-257	16	4	working	work	VERB
admet-257	16	5	with	with	ADP
admet-257	16	6	extremely	extremely	ADV
admet-257	16	7	small	small	ADJ
admet-257	16	8	quantities	quantity	NOUN
admet-257	16	9	which	which	PRON
admet-257	16	10	may	may	AUX
admet-257	16	11	in	in	ADP
admet-257	16	12	turn	turn	NOUN
admet-257	16	13	be	be	AUX
admet-257	16	14	so	so	ADV
admet-257	16	15	small	small	ADJ
admet-257	16	16	that	that	SCONJ
admet-257	16	17	they	they	PRON
admet-257	16	18	are	be	AUX
admet-257	16	19	ineffective	ineffective	ADJ
admet-257	16	20	even	even	ADV
admet-257	16	21	on	on	ADP
admet-257	16	22	an	an	DET
admet-257	16	23	animal	animal	NOUN
admet-257	16	24	of	of	ADP
admet-257	16	25	such	such	ADJ
admet-257	16	26	small	small	ADJ
admet-257	16	27	size	size	NOUN
admet-257	16	28	.	.	PUNCT
admet-257	17	1	that	that	SCONJ
admet-257	17	2	certain	certain	ADJ
admet-257	17	3	drugs	drug	NOUN
admet-257	17	4	may	may	AUX
admet-257	17	5	have	have	AUX
admet-257	17	6	a	a	DET
admet-257	17	7	threshold	threshold	NOUN
admet-257	17	8	level	level	NOUN
admet-257	17	9	before	before	SCONJ
admet-257	17	10	they	they	PRON
admet-257	17	11	have	have	VERB
admet-257	17	12	any	any	DET
admet-257	17	13	efficacy	efficacy	NOUN
admet-257	17	14	is	be	AUX
admet-257	17	15	a	a	DET
admet-257	17	16	commonly	commonly	ADV
admet-257	17	17	found	find	VERB
admet-257	17	18	factor	factor	NOUN
admet-257	17	19	,	,	PUNCT
admet-257	17	20	but	but	CCONJ
admet-257	17	21	in	in	ADP
admet-257	17	22	terms	term	NOUN
admet-257	17	23	of	of	ADP
admet-257	17	24	trying	try	VERB
admet-257	17	25	to	to	PART
admet-257	17	26	identify	identify	VERB
admet-257	17	27	what	what	PRON
admet-257	17	28	that	that	DET
admet-257	17	29	threshold	threshold	NOUN
admet-257	17	30	might	might	AUX
admet-257	17	31	be	be	AUX
admet-257	17	32	,	,	PUNCT
admet-257	17	33	often	often	ADV
admet-257	17	34	numerous	numerous	ADJ
admet-257	17	35	pilot	pilot	NOUN
admet-257	17	36	studies	study	NOUN
admet-257	17	37	are	be	AUX
admet-257	17	38	required	require	VERB
admet-257	17	39	which	which	PRON
admet-257	17	40	not	not	PART
admet-257	17	41	only	only	ADV
admet-257	17	42	involve	involve	VERB
admet-257	17	43	time	time	NOUN
admet-257	17	44	and	and	CCONJ
admet-257	17	45	expense	expense	NOUN
admet-257	17	46	on	on	ADP
admet-257	17	47	behalf	behalf	NOUN
admet-257	17	48	of	of	ADP
admet-257	17	49	the	the	DET
admet-257	17	50	principal	principal	ADJ
admet-257	17	51	investigator	investigator	NOUN
admet-257	17	52	but	but	CCONJ
admet-257	17	53	may	may	AUX
admet-257	17	54	be	be	AUX
admet-257	17	55	exorbitant	exorbitant	ADJ
admet-257	17	56	in	in	ADP
admet-257	17	57	the	the	DET
admet-257	17	58	number	number	NOUN
admet-257	17	59	of	of	ADP
admet-257	17	60	animals	animal	NOUN
admet-257	17	61	sacrificed	sacrifice	VERB
admet-257	17	62	in	in	ADP
admet-257	17	63	order	order	NOUN
admet-257	17	64	to	to	PART
admet-257	17	65	find	find	VERB
admet-257	17	66	that	that	DET
admet-257	17	67	level	level	NOUN
admet-257	17	68	.	.	PUNCT
admet-257	18	1	even	even	ADV
admet-257	18	2	so	so	ADV
admet-257	18	3	,	,	PUNCT
admet-257	18	4	once	once	ADV
admet-257	18	5	established	establish	VERB
admet-257	18	6	,	,	PUNCT
admet-257	18	7	will	will	AUX
admet-257	18	8	this	this	DET
admet-257	18	9	threshold	threshold	NOUN
admet-257	18	10	really	really	ADV
admet-257	18	11	correlate	correlate	VERB
admet-257	18	12	to	to	ADP
admet-257	18	13	the	the	DET
admet-257	18	14	quantity	quantity	NOUN
admet-257	18	15	that	that	PRON
admet-257	18	16	must	must	AUX
admet-257	18	17	be	be	AUX
admet-257	18	18	administered	administer	VERB
admet-257	18	19	to	to	ADP
admet-257	18	20	humans	human	NOUN
admet-257	18	21	?	?	PUNCT
admet-257	19	1	the	the	DET
admet-257	19	2	dosages	dosage	NOUN
admet-257	19	3	may	may	AUX
admet-257	19	4	be	be	AUX
admet-257	19	5	so	so	ADV
admet-257	19	6	high	high	ADJ
admet-257	19	7	,	,	PUNCT
admet-257	19	8	that	that	SCONJ
admet-257	19	9	the	the	DET
admet-257	19	10	equivalent	equivalent	ADJ
admet-257	19	11	dosage	dosage	NOUN
admet-257	19	12	on	on	ADP
admet-257	19	13	a	a	DET
admet-257	19	14	dose	dose	NOUN
admet-257	19	15	/	/	SYM
admet-257	19	16	kg	kg	PROPN
admet-257	19	17	basis	basis	NOUN
admet-257	19	18	may	may	AUX
admet-257	19	19	far	far	ADV
admet-257	19	20	exceed	exceed	VERB
admet-257	19	21	the	the	DET
admet-257	19	22	safe	safe	ADJ
admet-257	19	23	levels	level	NOUN
admet-257	19	24	for	for	ADP
admet-257	19	25	human	human	ADJ
admet-257	19	26	administration	administration	NOUN
admet-257	19	27	.	.	PUNCT
admet-257	20	1	sensitivity	sensitivity	NOUN
admet-257	20	2	to	to	ADP
admet-257	20	3	particular	particular	ADJ
admet-257	20	4	drugs	drug	NOUN
admet-257	20	5	and	and	CCONJ
admet-257	20	6	treatments	treatment	NOUN
admet-257	20	7	will	will	AUX
admet-257	20	8	vary	vary	VERB
admet-257	20	9	between	between	ADP
admet-257	20	10	species	specie	NOUN
admet-257	20	11	,	,	PUNCT
admet-257	20	12	simply	simply	ADV
admet-257	20	13	because	because	SCONJ
admet-257	20	14	we	we	PRON
admet-257	20	15	are	be	AUX
admet-257	20	16	different	different	ADJ
admet-257	20	17	as	as	SCONJ
admet-257	20	18	even	even	ADV
admet-257	20	19	the	the	DET
admet-257	20	20	best	well	ADV
admet-257	20	21	humanized	humanize	VERB
admet-257	20	22	models	model	NOUN
admet-257	20	23	can	can	AUX
admet-257	20	24	confirm	confirm	VERB
admet-257	20	25	.	.	PUNCT
admet-257	21	1	but	but	CCONJ
admet-257	21	2	the	the	DET
admet-257	21	3	danger	danger	NOUN
admet-257	21	4	in	in	ADP
admet-257	21	5	relying	rely	VERB
admet-257	21	6	on	on	ADP
admet-257	21	7	the	the	DET
admet-257	21	8	dose	dose	NOUN
admet-257	21	9	established	establish	VERB
admet-257	21	10	in	in	ADP
admet-257	21	11	the	the	DET
admet-257	21	12	animal	animal	NOUN
admet-257	21	13	model	model	NOUN
admet-257	21	14	as	as	ADP
admet-257	21	15	a	a	DET
admet-257	21	16	guideline	guideline	NOUN
admet-257	21	17	for	for	ADP
admet-257	21	18	even	even	ADV
admet-257	21	19	administering	administer	VERB
admet-257	21	20	a	a	DET
admet-257	21	21	much	much	ADV
admet-257	21	22	lower	low	ADJ
admet-257	21	23	dose	dose	NOUN
admet-257	21	24	in	in	ADP
admet-257	21	25	humans	human	NOUN
admet-257	21	26	is	be	AUX
admet-257	21	27	a	a	DET
admet-257	21	28	minefield	minefield	NOUN
admet-257	21	29	as	as	SCONJ
admet-257	21	30	was	be	AUX
admet-257	21	31	clearly	clearly	ADV
admet-257	21	32	evident	evident	ADJ
admet-257	21	33	in	in	ADP
admet-257	21	34	the	the	DET
admet-257	21	35	limited	limited	ADJ
admet-257	21	36	clinical	clinical	ADJ
admet-257	21	37	trial	trial	NOUN
admet-257	21	38	of	of	ADP
admet-257	21	39	tgn	tgn	NOUN
admet-257	21	40	1412	1412	NUM
admet-257	21	41	,	,	PUNCT
admet-257	21	42	using	use	VERB
admet-257	21	43	a	a	DET
admet-257	21	44	mousehuman	mousehuman	NOUN
admet-257	21	45	hybrid	hybrid	ADJ
admet-257	21	46	antibody	antibody	NOUN
admet-257	21	47	that	that	PRON
admet-257	21	48	resulted	result	VERB
admet-257	21	49	in	in	ADP
admet-257	21	50	a	a	DET
admet-257	21	51	cytokine	cytokine	ADJ
admet-257	21	52	storm	storm	NOUN
admet-257	21	53	event	event	NOUN
admet-257	21	54	[	[	X
admet-257	21	55	1	1	NUM
admet-257	21	56	]	]	PUNCT
admet-257	21	57	.	.	PUNCT
admet-257	22	1	what	what	PRON
admet-257	22	2	that	that	DET
admet-257	22	3	particular	particular	ADJ
admet-257	22	4	case	case	NOUN
admet-257	22	5	brings	bring	VERB
admet-257	22	6	to	to	ADP
admet-257	22	7	mind	mind	NOUN
admet-257	22	8	is	be	AUX
admet-257	22	9	that	that	SCONJ
admet-257	22	10	the	the	DET
admet-257	22	11	animal	animal	NOUN
admet-257	22	12	model	model	NOUN
admet-257	22	13	itself	itself	PRON
admet-257	22	14	was	be	AUX
admet-257	22	15	incapable	incapable	ADJ
admet-257	22	16	of	of	ADP
admet-257	22	17	manifesting	manifest	VERB
admet-257	22	18	the	the	DET
admet-257	22	19	adverse	adverse	ADJ
admet-257	22	20	response	response	NOUN
admet-257	22	21	evident	evident	ADJ
admet-257	22	22	in	in	ADP
admet-257	22	23	humans	human	NOUN
admet-257	22	24	and	and	CCONJ
admet-257	22	25	therefore	therefore	ADV
admet-257	22	26	left	leave	VERB
admet-257	22	27	a	a	DET
admet-257	22	28	huge	huge	ADJ
admet-257	22	29	gap	gap	NOUN
admet-257	22	30	of	of	ADP
admet-257	22	31	possible	possible	ADJ
admet-257	22	32	or	or	CCONJ
admet-257	22	33	unknown	unknown	ADJ
admet-257	22	34	consequences	consequence	NOUN
admet-257	22	35	that	that	PRON
admet-257	22	36	only	only	ADV
admet-257	22	37	became	become	VERB
admet-257	22	38	clear	clear	ADJ
admet-257	22	39	when	when	SCONJ
admet-257	22	40	administered	administer	VERB
admet-257	22	41	into	into	ADP
admet-257	22	42	human	human	ADJ
admet-257	22	43	subjects	subject	NOUN
admet-257	22	44	.	.	PUNCT
admet-257	23	1	we	we	PRON
admet-257	23	2	can	can	AUX
admet-257	23	3	extrapolate	extrapolate	VERB
admet-257	23	4	this	this	DET
admet-257	23	5	same	same	ADJ
admet-257	23	6	concept	concept	NOUN
admet-257	23	7	into	into	ADP
admet-257	23	8	animal	animal	NOUN
admet-257	23	9	models	model	NOUN
admet-257	23	10	of	of	ADP
admet-257	23	11	disease	disease	NOUN
admet-257	23	12	such	such	ADJ
admet-257	23	13	as	as	ADP
admet-257	23	14	diabetes	diabetes	NOUN
admet-257	23	15	both	both	DET
admet-257	23	16	type	type	VERB
admet-257	23	17	i	i	PRON
admet-257	23	18	and	and	CCONJ
admet-257	23	19	type	type	PROPN
admet-257	23	20	ii	ii	PROPN
admet-257	23	21	,	,	PUNCT
admet-257	23	22	which	which	PRON
admet-257	23	23	although	although	SCONJ
admet-257	23	24	similar	similar	ADJ
admet-257	23	25	to	to	ADP
admet-257	23	26	their	their	PRON
admet-257	23	27	counterparts	counterpart	NOUN
admet-257	23	28	in	in	ADP
admet-257	23	29	humans	human	NOUN
admet-257	23	30	,	,	PUNCT
admet-257	23	31	are	be	AUX
admet-257	23	32	not	not	PART
admet-257	23	33	identical	identical	ADJ
admet-257	23	34	,	,	PUNCT
admet-257	23	35	and	and	CCONJ
admet-257	23	36	as	as	SCONJ
admet-257	23	37	we	we	PRON
admet-257	23	38	have	have	AUX
admet-257	23	39	come	come	VERB
admet-257	23	40	to	to	PART
admet-257	23	41	appreciate	appreciate	VERB
admet-257	23	42	,	,	PUNCT
admet-257	23	43	will	will	AUX
admet-257	23	44	not	not	PART
admet-257	23	45	respond	respond	VERB
admet-257	23	46	in	in	ADP
admet-257	23	47	the	the	DET
admet-257	23	48	same	same	ADJ
admet-257	23	49	manner	manner	NOUN
admet-257	23	50	in	in	ADP
admet-257	23	51	both	both	DET
admet-257	23	52	species	specie	NOUN
admet-257	23	53	to	to	ADP
admet-257	23	54	the	the	DET
admet-257	23	55	same	same	ADJ
admet-257	23	56	drug	drug	NOUN
admet-257	23	57	.	.	PUNCT
admet-257	24	1	as	as	SCONJ
admet-257	24	2	can	can	AUX
admet-257	24	3	be	be	AUX
admet-257	24	4	heard	hear	VERB
admet-257	24	5	in	in	ADP
admet-257	24	6	many	many	ADJ
admet-257	24	7	institutions	institution	NOUN
admet-257	24	8	,	,	PUNCT
admet-257	24	9	“	"	PUNCT
admet-257	24	10	we	we	PRON
admet-257	24	11	have	have	VERB
admet-257	24	12	some	some	DET
admet-257	24	13	excellent	excellent	ADJ
admet-257	24	14	cures	cure	NOUN
admet-257	24	15	for	for	ADP
admet-257	24	16	diabetes	diabetes	NOUN
admet-257	24	17	in	in	ADP
admet-257	24	18	mice	mouse	NOUN
admet-257	24	19	but	but	CCONJ
admet-257	24	20	unfortunately	unfortunately	ADV
admet-257	24	21	they	they	PRON
admet-257	24	22	have	have	AUX
admet-257	24	23	proven	prove	VERB
admet-257	24	24	of	of	ADP
admet-257	24	25	little	little	ADJ
admet-257	24	26	value	value	NOUN
admet-257	24	27	in	in	ADP
admet-257	24	28	humans	human	NOUN
admet-257	24	29	.	.	PUNCT
admet-257	24	30	”	"	PUNCT
admet-257	25	1	as	as	SCONJ
admet-257	25	2	some	some	PRON
admet-257	25	3	of	of	ADP
admet-257	25	4	these	these	DET
admet-257	25	5	models	model	NOUN
admet-257	25	6	are	be	AUX
admet-257	25	7	induced	induce	VERB
admet-257	25	8	,	,	PUNCT
admet-257	25	9	rather	rather	ADV
admet-257	25	10	than	than	ADP
admet-257	25	11	having	have	VERB
admet-257	25	12	an	an	DET
admet-257	25	13	identical	identical	ADJ
admet-257	25	14	genetic	genetic	ADJ
admet-257	25	15	predisposition	predisposition	NOUN
admet-257	25	16	or	or	CCONJ
admet-257	25	17	aetiology	aetiology	NOUN
admet-257	25	18	as	as	ADP
admet-257	25	19	in	in	ADP
admet-257	25	20	the	the	DET
admet-257	25	21	human	human	ADJ
admet-257	25	22	subject	subject	NOUN
admet-257	25	23	,	,	PUNCT
admet-257	25	24	even	even	ADV
admet-257	25	25	though	though	SCONJ
admet-257	25	26	we	we	PRON
admet-257	25	27	will	will	AUX
admet-257	25	28	classify	classify	VERB
admet-257	25	29	them	they	PRON
admet-257	25	30	as	as	ADP
admet-257	25	31	type	type	NOUN
admet-257	25	32	i	i	PRON
admet-257	25	33	or	or	CCONJ
admet-257	25	34	type	type	NOUN
admet-257	25	35	ii	ii	NOUN
admet-257	25	36	diabetes	diabetes	NOUN
admet-257	25	37	they	they	PRON
admet-257	25	38	are	be	AUX
admet-257	25	39	in	in	ADP
admet-257	25	40	fact	fact	NOUN
admet-257	25	41	mimics	mimic	NOUN
admet-257	25	42	of	of	ADP
admet-257	25	43	the	the	DET
admet-257	25	44	disease	disease	NOUN
admet-257	25	45	but	but	CCONJ
admet-257	25	46	not	not	PART
admet-257	25	47	the	the	DET
admet-257	25	48	identical	identical	ADJ
admet-257	25	49	human	human	ADJ
admet-257	25	50	disease	disease	NOUN
admet-257	25	51	.	.	PUNCT
admet-257	26	1	pre	pre	ADJ
admet-257	26	2	-	-	ADJ
admet-257	26	3	test	test	ADJ
admet-257	26	4	requirements	requirement	NOUN
admet-257	26	5	and	and	CCONJ
admet-257	26	6	resolutions	resolution	NOUN
admet-257	26	7	as	as	ADP
admet-257	26	8	such	such	ADJ
admet-257	26	9	,	,	PUNCT
admet-257	26	10	it	it	PRON
admet-257	26	11	is	be	AUX
admet-257	26	12	important	important	ADJ
admet-257	26	13	that	that	SCONJ
admet-257	26	14	prior	prior	ADV
admet-257	26	15	to	to	ADP
admet-257	26	16	conducting	conduct	VERB
admet-257	26	17	a	a	DET
admet-257	26	18	preclinical	preclinical	ADJ
admet-257	26	19	test	test	NOUN
admet-257	26	20	for	for	ADP
admet-257	26	21	a	a	DET
admet-257	26	22	drug	drug	NOUN
admet-257	26	23	,	,	PUNCT
admet-257	26	24	we	we	PRON
admet-257	26	25	must	must	AUX
admet-257	26	26	first	first	ADV
admet-257	26	27	demonstrate	demonstrate	VERB
admet-257	26	28	that	that	SCONJ
admet-257	26	29	the	the	DET
admet-257	26	30	model	model	NOUN
admet-257	26	31	we	we	PRON
admet-257	26	32	will	will	AUX
admet-257	26	33	use	use	VERB
admet-257	26	34	has	have	AUX
admet-257	26	35	been	be	AUX
admet-257	26	36	proven	prove	VERB
admet-257	26	37	or	or	CCONJ
admet-257	26	38	shown	show	VERB
admet-257	26	39	to	to	PART
admet-257	26	40	be	be	AUX
admet-257	26	41	a	a	DET
admet-257	26	42	reflection	reflection	NOUN
admet-257	26	43	of	of	ADP
admet-257	26	44	the	the	DET
admet-257	26	45	human	human	ADJ
admet-257	26	46	counterpart	counterpart	NOUN
admet-257	26	47	and	and	CCONJ
admet-257	26	48	therefore	therefore	ADV
admet-257	26	49	there	there	PRON
admet-257	26	50	is	be	VERB
admet-257	26	51	a	a	DET
admet-257	26	52	higher	high	ADJ
admet-257	26	53	value	value	NOUN
admet-257	26	54	to	to	ADP
admet-257	26	55	any	any	DET
admet-257	26	56	data	datum	NOUN
admet-257	26	57	generated	generate	VERB
admet-257	26	58	from	from	ADP
admet-257	26	59	the	the	DET
admet-257	26	60	study	study	NOUN
admet-257	26	61	.	.	PUNCT
admet-257	27	1	this	this	PRON
admet-257	27	2	requires	require	VERB
admet-257	27	3	that	that	SCONJ
admet-257	27	4	we	we	PRON
admet-257	27	5	have	have	VERB
admet-257	27	6	both	both	CCONJ
admet-257	27	7	invitro	invitro	ADJ
admet-257	27	8	and	and	CCONJ
admet-257	27	9	computational	computational	ADJ
admet-257	27	10	studies	study	NOUN
admet-257	27	11	to	to	PART
admet-257	27	12	verify	verify	VERB
admet-257	27	13	the	the	DET
admet-257	27	14	evidence	evidence	NOUN
admet-257	27	15	and	and	CCONJ
admet-257	27	16	increase	increase	VERB
admet-257	27	17	the	the	DET
admet-257	27	18	probability	probability	NOUN
admet-257	27	19	of	of	ADP
admet-257	27	20	a	a	DET
admet-257	27	21	successful	successful	ADJ
admet-257	27	22	outcome	outcome	NOUN
admet-257	27	23	.	.	PUNCT
admet-257	28	1	without	without	ADP
admet-257	28	2	this	this	DET
admet-257	28	3	initial	initial	ADJ
admet-257	28	4	testing	testing	NOUN
admet-257	28	5	,	,	PUNCT
admet-257	28	6	moving	move	VERB
admet-257	28	7	forward	forward	ADV
admet-257	28	8	into	into	ADP
admet-257	28	9	animal	animal	NOUN
admet-257	28	10	testing	testing	NOUN
admet-257	28	11	should	should	AUX
admet-257	28	12	not	not	PART
admet-257	28	13	be	be	AUX
admet-257	28	14	considered	consider	VERB
admet-257	28	15	.	.	PUNCT
admet-257	29	1	secondly	secondly	ADV
admet-257	29	2	,	,	PUNCT
admet-257	29	3	we	we	PRON
admet-257	29	4	must	must	AUX
admet-257	29	5	have	have	VERB
admet-257	29	6	all	all	DET
admet-257	29	7	the	the	DET
admet-257	29	8	information	information	NOUN
admet-257	29	9	at	at	ADP
admet-257	29	10	hand	hand	NOUN
admet-257	29	11	concerning	concern	VERB
admet-257	29	12	the	the	DET
admet-257	29	13	drug	drug	NOUN
admet-257	29	14	being	be	AUX
admet-257	29	15	tested	test	VERB
admet-257	29	16	,	,	PUNCT
admet-257	29	17	or	or	CCONJ
admet-257	29	18	a	a	DET
admet-257	29	19	similar	similar	ADJ
admet-257	29	20	drug	drug	NOUN
admet-257	29	21	from	from	ADP
admet-257	29	22	the	the	DET
admet-257	29	23	same	same	ADJ
admet-257	29	24	family	family	NOUN
admet-257	29	25	of	of	ADP
admet-257	29	26	compounds	compound	NOUN
admet-257	29	27	,	,	PUNCT
admet-257	29	28	especially	especially	ADV
admet-257	29	29	where	where	SCONJ
admet-257	29	30	it	it	PRON
admet-257	29	31	concerns	concern	VERB
admet-257	29	32	previous	previous	ADJ
admet-257	29	33	animal	animal	NOUN
admet-257	29	34	models	model	NOUN
admet-257	29	35	tested	test	VERB
admet-257	29	36	.	.	PUNCT
admet-257	30	1	if	if	SCONJ
admet-257	30	2	similar	similar	ADJ
admet-257	30	3	or	or	CCONJ
admet-257	30	4	related	related	ADJ
admet-257	30	5	class	class	NOUN
admet-257	30	6	of	of	ADP
admet-257	30	7	drugs	drug	NOUN
admet-257	30	8	were	be	AUX
admet-257	30	9	reported	report	VERB
admet-257	30	10	in	in	ADP
admet-257	30	11	preclinical	preclinical	ADJ
admet-257	30	12	trials	trial	NOUN
admet-257	30	13	,	,	PUNCT
admet-257	30	14	having	having	AUX
admet-257	30	15	failed	fail	VERB
admet-257	30	16	to	to	PART
admet-257	30	17	move	move	VERB
admet-257	30	18	forward	forward	ADV
admet-257	30	19	into	into	ADP
admet-257	30	20	human	human	ADJ
admet-257	30	21	trials	trial	NOUN
admet-257	30	22	,	,	PUNCT
admet-257	30	23	or	or	CCONJ
admet-257	30	24	in	in	ADP
admet-257	30	25	fact	fact	NOUN
admet-257	30	26	failing	fail	VERB
admet-257	30	27	in	in	ADP
admet-257	30	28	human	human	ADJ
admet-257	30	29	trials	trial	NOUN
admet-257	30	30	,	,	PUNCT
admet-257	30	31	then	then	ADV
admet-257	30	32	it	it	PRON
admet-257	30	33	is	be	AUX
admet-257	30	34	ethically	ethically	ADV
admet-257	30	35	important	important	ADJ
admet-257	30	36	to	to	PART
admet-257	30	37	make	make	VERB
admet-257	30	38	the	the	DET
admet-257	30	39	argument	argument	NOUN
admet-257	30	40	as	as	ADP
admet-257	30	41	to	to	ADP
admet-257	30	42	why	why	SCONJ
admet-257	30	43	the	the	DET
admet-257	30	44	particular	particular	ADJ
admet-257	30	45	drug	drug	NOUN
admet-257	30	46	now	now	ADV
admet-257	30	47	being	be	AUX
admet-257	30	48	tested	test	VERB
admet-257	30	49	will	will	AUX
admet-257	30	50	have	have	VERB
admet-257	30	51	a	a	DET
admet-257	30	52	greater	great	ADJ
admet-257	30	53	chance	chance	NOUN
admet-257	30	54	to	to	PART
admet-257	30	55	succeed	succeed	VERB
admet-257	30	56	than	than	SCONJ
admet-257	30	57	it	it	PRON
admet-257	30	58	did	do	VERB
admet-257	30	59	in	in	ADP
admet-257	30	60	the	the	DET
admet-257	30	61	prior	prior	ADJ
admet-257	30	62	tests	test	NOUN
admet-257	30	63	.	.	PUNCT
admet-257	31	1	if	if	SCONJ
admet-257	31	2	such	such	DET
admet-257	31	3	an	an	DET
admet-257	31	4	argument	argument	NOUN
admet-257	31	5	can	can	AUX
admet-257	31	6	not	not	PART
admet-257	31	7	be	be	AUX
admet-257	31	8	made	make	VERB
admet-257	31	9	and	and	CCONJ
admet-257	31	10	subsequently	subsequently	ADV
admet-257	31	11	approved	approve	VERB
admet-257	31	12	,	,	PUNCT
admet-257	31	13	then	then	ADV
admet-257	31	14	once	once	ADV
admet-257	31	15	again	again	ADV
admet-257	31	16	animal	animal	NOUN
admet-257	31	17	testing	testing	NOUN
admet-257	31	18	should	should	AUX
admet-257	31	19	not	not	PART
admet-257	31	20	be	be	AUX
admet-257	31	21	considered	consider	VERB
admet-257	31	22	.	.	PUNCT
admet-257	32	1	admet	admet	PROPN
admet-257	32	2	&	&	CCONJ
admet-257	32	3	dmpk	dmpk	PROPN
admet-257	32	4	3(4	3(4	NUM
admet-257	32	5	)	)	PUNCT
admet-257	32	6	(	(	PUNCT
admet-257	32	7	2015	2015	NUM
admet-257	32	8	)	)	PUNCT
admet-257	32	9	363	363	NUM
admet-257	32	10	-	-	SYM
admet-257	32	11	365	365	NUM
admet-257	32	12	ethical	ethical	ADJ
admet-257	32	13	considerations	consideration	NOUN
admet-257	32	14	of	of	ADP
admet-257	32	15	preclinical	preclinical	ADJ
admet-257	32	16	testing	testing	NOUN
admet-257	32	17	doi	doi	NOUN
admet-257	32	18	:	:	PUNCT
admet-257	32	19	10.5599	10.5599	NUM
admet-257	32	20	/	/	SYM
admet-257	32	21	admet.3.4.257	admet.3.4.257	NUM
admet-257	32	22	365	365	NUM
admet-257	32	23	in	in	ADP
admet-257	32	24	this	this	DET
admet-257	32	25	vein	vein	NOUN
admet-257	32	26	,	,	PUNCT
admet-257	32	27	a	a	DET
admet-257	32	28	third	third	ADJ
admet-257	32	29	issue	issue	NOUN
admet-257	32	30	is	be	AUX
admet-257	32	31	that	that	SCONJ
admet-257	32	32	much	much	ADJ
admet-257	32	33	of	of	ADP
admet-257	32	34	preclinical	preclinical	ADJ
admet-257	32	35	research	research	NOUN
admet-257	32	36	outcomes	outcome	NOUN
admet-257	32	37	are	be	AUX
admet-257	32	38	never	never	ADV
admet-257	32	39	published	publish	VERB
admet-257	32	40	and	and	CCONJ
admet-257	32	41	that	that	PRON
admet-257	32	42	distorts	distort	VERB
admet-257	32	43	the	the	DET
admet-257	32	44	evidence	evidence	NOUN
admet-257	32	45	base	base	NOUN
admet-257	32	46	on	on	ADP
admet-257	32	47	which	which	PRON
admet-257	32	48	to	to	PART
admet-257	32	49	make	make	VERB
admet-257	32	50	decisions	decision	NOUN
admet-257	32	51	.	.	PUNCT
admet-257	33	1	when	when	SCONJ
admet-257	33	2	we	we	PRON
admet-257	33	3	say	say	VERB
admet-257	33	4	that	that	SCONJ
admet-257	33	5	researchers	researcher	NOUN
admet-257	33	6	should	should	AUX
admet-257	33	7	be	be	AUX
admet-257	33	8	interpreting	interpret	VERB
admet-257	33	9	preclinical	preclinical	ADJ
admet-257	33	10	outcomes	outcome	NOUN
admet-257	33	11	in	in	ADP
admet-257	33	12	light	light	NOUN
admet-257	33	13	of	of	ADP
admet-257	33	14	how	how	SCONJ
admet-257	33	15	similar	similar	ADJ
admet-257	33	16	drugs	drug	NOUN
admet-257	33	17	have	have	AUX
admet-257	33	18	performed	perform	VERB
admet-257	33	19	in	in	ADP
admet-257	33	20	the	the	DET
admet-257	33	21	past	past	NOUN
admet-257	33	22	,	,	PUNCT
admet-257	33	23	it	it	PRON
admet-257	33	24	is	be	AUX
admet-257	33	25	very	very	ADV
admet-257	33	26	difficult	difficult	ADJ
admet-257	33	27	to	to	PART
admet-257	33	28	do	do	VERB
admet-257	33	29	that	that	SCONJ
admet-257	33	30	if	if	SCONJ
admet-257	33	31	one	one	PRON
admet-257	33	32	simply	simply	ADV
admet-257	33	33	can	can	AUX
admet-257	33	34	not	not	PART
admet-257	33	35	consult	consult	VERB
admet-257	33	36	the	the	DET
admet-257	33	37	record	record	NOUN
admet-257	33	38	of	of	ADP
admet-257	33	39	prior	prior	ADJ
admet-257	33	40	drugs	drug	NOUN
admet-257	33	41	because	because	SCONJ
admet-257	33	42	the	the	DET
admet-257	33	43	results	result	NOUN
admet-257	33	44	were	be	AUX
admet-257	33	45	not	not	PART
admet-257	33	46	published	publish	VERB
admet-257	33	47	as	as	ADP
admet-257	33	48	a	a	DET
admet-257	33	49	corporate	corporate	ADJ
admet-257	33	50	or	or	CCONJ
admet-257	33	51	institutional	institutional	ADJ
admet-257	33	52	decision	decision	NOUN
admet-257	33	53	.	.	PUNCT
admet-257	34	1	we	we	PRON
admet-257	34	2	would	would	AUX
admet-257	34	3	want	want	VERB
admet-257	34	4	to	to	PART
admet-257	34	5	see	see	VERB
admet-257	34	6	measures	measure	NOUN
admet-257	34	7	going	go	VERB
admet-257	34	8	forward	forward	ADV
admet-257	34	9	that	that	PRON
admet-257	34	10	encourage	encourage	VERB
admet-257	34	11	and	and	CCONJ
admet-257	34	12	incentivize	incentivize	VERB
admet-257	34	13	publication	publication	NOUN
admet-257	34	14	of	of	ADP
admet-257	34	15	all	all	DET
admet-257	34	16	preclinical	preclinical	ADJ
admet-257	34	17	results	result	NOUN
admet-257	34	18	,	,	PUNCT
admet-257	34	19	even	even	ADV
admet-257	34	20	if	if	SCONJ
admet-257	34	21	those	those	DET
admet-257	34	22	results	result	NOUN
admet-257	34	23	were	be	AUX
admet-257	34	24	negative	negative	ADJ
admet-257	34	25	,	,	PUNCT
admet-257	34	26	as	as	SCONJ
admet-257	34	27	this	this	PRON
admet-257	34	28	is	be	AUX
admet-257	34	29	vitally	vitally	ADV
admet-257	34	30	important	important	ADJ
admet-257	34	31	to	to	PART
admet-257	34	32	reduce	reduce	VERB
admet-257	34	33	redundancy	redundancy	NOUN
admet-257	34	34	of	of	ADP
admet-257	34	35	experiments	experiment	NOUN
admet-257	34	36	with	with	ADP
admet-257	34	37	no	no	DET
admet-257	34	38	chance	chance	NOUN
admet-257	34	39	of	of	ADP
admet-257	34	40	success	success	NOUN
admet-257	34	41	,	,	PUNCT
admet-257	34	42	a	a	DET
admet-257	34	43	situation	situation	NOUN
admet-257	34	44	which	which	PRON
admet-257	34	45	is	be	AUX
admet-257	34	46	frequently	frequently	ADV
admet-257	34	47	happening	happen	VERB
admet-257	34	48	within	within	ADP
admet-257	34	49	our	our	PRON
admet-257	34	50	current	current	ADJ
admet-257	34	51	framework	framework	NOUN
admet-257	34	52	.	.	PUNCT
admet-257	35	1	fourthly	fourthly	ADV
admet-257	35	2	,	,	PUNCT
admet-257	35	3	we	we	PRON
admet-257	35	4	should	should	AUX
admet-257	35	5	perform	perform	VERB
admet-257	35	6	an	an	DET
admet-257	35	7	up	up	ADP
admet-257	35	8	-	-	PUNCT
admet-257	35	9	down	down	ADP
admet-257	35	10	study	study	NOUN
admet-257	35	11	using	use	VERB
admet-257	35	12	a	a	DET
admet-257	35	13	minimum	minimum	ADJ
admet-257	35	14	amount	amount	NOUN
admet-257	35	15	of	of	ADP
admet-257	35	16	animals	animal	NOUN
admet-257	35	17	in	in	ADP
admet-257	35	18	order	order	NOUN
admet-257	35	19	to	to	PART
admet-257	35	20	establish	establish	VERB
admet-257	35	21	what	what	PRON
admet-257	35	22	we	we	PRON
admet-257	35	23	believe	believe	VERB
admet-257	35	24	to	to	PART
admet-257	35	25	be	be	AUX
admet-257	35	26	the	the	DET
admet-257	35	27	noel	noel	NOUN
admet-257	35	28	(	(	PUNCT
admet-257	35	29	no	no	DET
admet-257	35	30	observable	observable	ADJ
admet-257	35	31	effects	effect	NOUN
admet-257	35	32	level	level	NOUN
admet-257	35	33	)	)	PUNCT
admet-257	35	34	,	,	PUNCT
admet-257	35	35	loel	loel	PROPN
admet-257	35	36	(	(	PUNCT
admet-257	35	37	lowest	low	ADJ
admet-257	35	38	observable	observable	ADJ
admet-257	35	39	effects	effect	NOUN
admet-257	35	40	level	level	NOUN
admet-257	35	41	)	)	PUNCT
admet-257	35	42	and	and	CCONJ
admet-257	35	43	mtd	mtd	PROPN
admet-257	35	44	(	(	PUNCT
admet-257	35	45	maximum	maximum	ADJ
admet-257	35	46	tolerated	tolerate	VERB
admet-257	35	47	dose	dose	NOUN
admet-257	35	48	)	)	PUNCT
admet-257	35	49	.	.	PUNCT
admet-257	36	1	by	by	ADP
admet-257	36	2	pairing	pair	VERB
admet-257	36	3	animals	animal	NOUN
admet-257	36	4	at	at	ADP
admet-257	36	5	a	a	DET
admet-257	36	6	particular	particular	ADJ
admet-257	36	7	dose	dose	NOUN
admet-257	36	8	then	then	ADV
admet-257	36	9	observing	observe	VERB
admet-257	36	10	for	for	ADP
admet-257	36	11	effects	effect	NOUN
admet-257	36	12	and	and	CCONJ
admet-257	36	13	based	base	VERB
admet-257	36	14	on	on	ADP
admet-257	36	15	those	those	DET
admet-257	36	16	results	result	NOUN
admet-257	36	17	determining	determine	VERB
admet-257	36	18	if	if	SCONJ
admet-257	36	19	the	the	DET
admet-257	36	20	next	next	ADJ
admet-257	36	21	pair	pair	NOUN
admet-257	36	22	of	of	ADP
admet-257	36	23	animals	animal	NOUN
admet-257	36	24	receive	receive	VERB
admet-257	36	25	a	a	DET
admet-257	36	26	higher	high	ADJ
admet-257	36	27	or	or	CCONJ
admet-257	36	28	lower	low	ADJ
admet-257	36	29	administrated	administrate	VERB
admet-257	36	30	dosage	dosage	NOUN
admet-257	36	31	,	,	PUNCT
admet-257	36	32	then	then	ADV
admet-257	36	33	we	we	PRON
admet-257	36	34	can	can	AUX
admet-257	36	35	establish	establish	VERB
admet-257	36	36	more	more	ADV
admet-257	36	37	effectively	effectively	ADV
admet-257	36	38	the	the	DET
admet-257	36	39	groupings	grouping	NOUN
admet-257	36	40	to	to	PART
admet-257	36	41	be	be	AUX
admet-257	36	42	used	use	VERB
admet-257	36	43	for	for	ADP
admet-257	36	44	any	any	DET
admet-257	36	45	preclinical	preclinical	ADJ
admet-257	36	46	study	study	NOUN
admet-257	36	47	.	.	PUNCT
admet-257	37	1	finally	finally	ADV
admet-257	37	2	,	,	PUNCT
admet-257	37	3	we	we	PRON
admet-257	37	4	must	must	AUX
admet-257	37	5	give	give	VERB
admet-257	37	6	consideration	consideration	NOUN
admet-257	37	7	to	to	ADP
admet-257	37	8	intercession	intercession	NOUN
admet-257	37	9	time	time	NOUN
admet-257	37	10	points	point	NOUN
admet-257	37	11	when	when	SCONJ
admet-257	37	12	establishing	establish	VERB
admet-257	37	13	the	the	DET
admet-257	37	14	protocol	protocol	NOUN
admet-257	37	15	or	or	CCONJ
admet-257	37	16	any	any	DET
admet-257	37	17	preclinical	preclinical	ADJ
admet-257	37	18	studies	study	NOUN
admet-257	37	19	.	.	PUNCT
admet-257	38	1	this	this	DET
admet-257	38	2	practice	practice	NOUN
admet-257	38	3	will	will	AUX
admet-257	38	4	identify	identify	VERB
admet-257	38	5	key	key	ADJ
admet-257	38	6	critical	critical	ADJ
admet-257	38	7	decision	decision	NOUN
admet-257	38	8	points	point	NOUN
admet-257	38	9	where	where	SCONJ
admet-257	38	10	the	the	DET
admet-257	38	11	study	study	NOUN
admet-257	38	12	should	should	AUX
admet-257	38	13	be	be	AUX
admet-257	38	14	terminated	terminate	VERB
admet-257	38	15	for	for	ADP
admet-257	38	16	reasons	reason	NOUN
admet-257	38	17	of	of	ADP
admet-257	38	18	either	either	CCONJ
admet-257	38	19	severe	severe	ADJ
admet-257	38	20	adverse	adverse	ADJ
admet-257	38	21	effects	effect	NOUN
admet-257	38	22	or	or	CCONJ
admet-257	38	23	no	no	DET
admet-257	38	24	indication	indication	NOUN
admet-257	38	25	of	of	ADP
admet-257	38	26	any	any	DET
admet-257	38	27	desired	desire	VERB
admet-257	38	28	effects	effect	NOUN
admet-257	38	29	.	.	PUNCT
admet-257	39	1	these	these	PRON
admet-257	39	2	require	require	VERB
admet-257	39	3	that	that	SCONJ
admet-257	39	4	a	a	DET
admet-257	39	5	scale	scale	NOUN
admet-257	39	6	be	be	AUX
admet-257	39	7	predetermined	predetermine	VERB
admet-257	39	8	of	of	ADP
admet-257	39	9	various	various	ADJ
admet-257	39	10	levels	level	NOUN
admet-257	39	11	of	of	ADP
admet-257	39	12	adverse	adverse	ADJ
admet-257	39	13	effects	effect	NOUN
admet-257	39	14	,	,	PUNCT
admet-257	39	15	as	as	ADV
admet-257	39	16	well	well	ADV
admet-257	39	17	as	as	ADP
admet-257	39	18	one	one	NUM
admet-257	39	19	on	on	ADP
admet-257	39	20	determining	determine	VERB
admet-257	39	21	data	datum	NOUN
admet-257	39	22	to	to	PART
admet-257	39	23	quantify	quantify	VERB
admet-257	39	24	that	that	SCONJ
admet-257	39	25	there	there	PRON
admet-257	39	26	is	be	VERB
admet-257	39	27	absolutely	absolutely	ADV
admet-257	39	28	no	no	DET
admet-257	39	29	beneficial	beneficial	ADJ
admet-257	39	30	outcome	outcome	NOUN
admet-257	39	31	before	before	ADP
admet-257	39	32	the	the	DET
admet-257	39	33	preclinical	preclinical	ADJ
admet-257	39	34	study	study	NOUN
admet-257	39	35	commences	commence	NOUN
admet-257	39	36	.	.	PUNCT
admet-257	40	1	conclusions	conclusion	NOUN
admet-257	40	2	it	it	PRON
admet-257	40	3	must	must	AUX
admet-257	40	4	be	be	AUX
admet-257	40	5	remembered	remember	VERB
admet-257	40	6	that	that	SCONJ
admet-257	40	7	preclinical	preclinical	ADJ
admet-257	40	8	studies	study	NOUN
admet-257	40	9	are	be	AUX
admet-257	40	10	all	all	PRON
admet-257	40	11	operated	operate	VERB
admet-257	40	12	under	under	ADP
admet-257	40	13	the	the	DET
admet-257	40	14	umbrella	umbrella	NOUN
admet-257	40	15	of	of	ADP
admet-257	40	16	good	good	ADJ
admet-257	40	17	laboratory	laboratory	NOUN
admet-257	40	18	practices	practice	NOUN
admet-257	40	19	(	(	PUNCT
admet-257	40	20	glp	glp	NOUN
admet-257	40	21	)	)	PUNCT
admet-257	40	22	and	and	CCONJ
admet-257	40	23	therefore	therefore	ADV
admet-257	40	24	any	any	DET
admet-257	40	25	principal	principal	ADJ
admet-257	40	26	investigator	investigator	NOUN
admet-257	40	27	conducting	conduct	VERB
admet-257	40	28	such	such	ADJ
admet-257	40	29	studies	study	NOUN
admet-257	40	30	must	must	AUX
admet-257	40	31	be	be	AUX
admet-257	40	32	familiar	familiar	ADJ
admet-257	40	33	with	with	ADP
admet-257	40	34	the	the	DET
admet-257	40	35	glp	glp	NOUN
admet-257	40	36	and	and	CCONJ
admet-257	40	37	that	that	SCONJ
admet-257	40	38	their	their	PRON
admet-257	40	39	assistants	assistant	NOUN
admet-257	40	40	are	be	AUX
admet-257	40	41	also	also	ADV
admet-257	40	42	equally	equally	ADV
admet-257	40	43	aware	aware	ADJ
admet-257	40	44	of	of	ADP
admet-257	40	45	the	the	DET
admet-257	40	46	regulatory	regulatory	ADJ
admet-257	40	47	requirements	requirement	NOUN
admet-257	40	48	for	for	ADP
admet-257	40	49	conducting	conduct	VERB
admet-257	40	50	a	a	DET
admet-257	40	51	preclinical	preclinical	ADJ
admet-257	40	52	study	study	NOUN
admet-257	40	53	before	before	SCONJ
admet-257	40	54	they	they	PRON
admet-257	40	55	participate	participate	VERB
admet-257	40	56	in	in	ADP
admet-257	40	57	the	the	DET
admet-257	40	58	trial	trial	NOUN
admet-257	40	59	.	.	PUNCT
admet-257	41	1	straying	stray	VERB
admet-257	41	2	from	from	ADP
admet-257	41	3	the	the	DET
admet-257	41	4	glp	glp	NOUN
admet-257	41	5	not	not	PART
admet-257	41	6	only	only	ADV
admet-257	41	7	places	place	VERB
admet-257	41	8	the	the	DET
admet-257	41	9	study	study	NOUN
admet-257	41	10	at	at	ADP
admet-257	41	11	risk	risk	NOUN
admet-257	41	12	but	but	CCONJ
admet-257	41	13	also	also	ADV
admet-257	41	14	any	any	DET
admet-257	41	15	data	datum	NOUN
admet-257	41	16	generated	generate	VERB
admet-257	41	17	from	from	ADP
admet-257	41	18	such	such	DET
admet-257	41	19	a	a	DET
admet-257	41	20	study	study	NOUN
admet-257	41	21	since	since	SCONJ
admet-257	41	22	it	it	PRON
admet-257	41	23	may	may	AUX
admet-257	41	24	not	not	PART
admet-257	41	25	accurately	accurately	ADV
admet-257	41	26	reflect	reflect	VERB
admet-257	41	27	the	the	DET
admet-257	41	28	actual	actual	ADJ
admet-257	41	29	effects	effect	NOUN
admet-257	41	30	of	of	ADP
admet-257	41	31	the	the	DET
admet-257	41	32	drug	drug	NOUN
admet-257	41	33	but	but	CCONJ
admet-257	41	34	may	may	AUX
admet-257	41	35	be	be	AUX
admet-257	41	36	unduly	unduly	ADV
admet-257	41	37	influenced	influence	VERB
admet-257	41	38	and	and	CCONJ
admet-257	41	39	adversely	adversely	ADV
admet-257	41	40	affected	affect	VERB
admet-257	41	41	by	by	ADP
admet-257	41	42	both	both	DET
admet-257	41	43	poor	poor	ADJ
admet-257	41	44	husbandry	husbandry	NOUN
admet-257	41	45	and	and	CCONJ
admet-257	41	46	animal	animal	NOUN
admet-257	41	47	management	management	NOUN
admet-257	41	48	.	.	PUNCT
admet-257	42	1	the	the	DET
admet-257	42	2	obtained	obtain	VERB
admet-257	42	3	results	result	NOUN
admet-257	42	4	from	from	ADP
admet-257	42	5	animal	animal	NOUN
admet-257	42	6	testing	testing	NOUN
admet-257	42	7	must	must	AUX
admet-257	42	8	undergo	undergo	VERB
admet-257	42	9	several	several	ADJ
admet-257	42	10	checks	check	NOUN
admet-257	42	11	for	for	ADP
admet-257	42	12	reliability	reliability	NOUN
admet-257	42	13	before	before	ADP
admet-257	42	14	presuming	presume	VERB
admet-257	42	15	there	there	PRON
admet-257	42	16	will	will	AUX
admet-257	42	17	be	be	AUX
admet-257	42	18	a	a	DET
admet-257	42	19	correlating	correlate	VERB
admet-257	42	20	beneficial	beneficial	ADJ
admet-257	42	21	effect	effect	NOUN
admet-257	42	22	in	in	ADP
admet-257	42	23	humans	human	NOUN
admet-257	42	24	.	.	PUNCT
admet-257	43	1	certain	certain	ADJ
admet-257	43	2	adverse	adverse	ADJ
admet-257	43	3	effects	effect	NOUN
admet-257	43	4	of	of	ADP
admet-257	43	5	the	the	DET
admet-257	43	6	therapy	therapy	NOUN
admet-257	43	7	may	may	AUX
admet-257	43	8	go	go	VERB
admet-257	43	9	completely	completely	ADV
admet-257	43	10	undetected	undetected	ADJ
admet-257	43	11	because	because	SCONJ
admet-257	43	12	we	we	PRON
admet-257	43	13	do	do	AUX
admet-257	43	14	not	not	PART
admet-257	43	15	have	have	VERB
admet-257	43	16	the	the	DET
admet-257	43	17	ability	ability	NOUN
admet-257	43	18	to	to	PART
admet-257	43	19	recognize	recognize	VERB
admet-257	43	20	subclinical	subclinical	ADJ
admet-257	43	21	or	or	CCONJ
admet-257	43	22	monitor	monitor	VERB
admet-257	43	23	low	low	ADJ
admet-257	43	24	incidence	incidence	NOUN
admet-257	43	25	effects	effect	NOUN
admet-257	43	26	in	in	ADP
admet-257	43	27	animals	animal	NOUN
admet-257	43	28	such	such	ADJ
admet-257	43	29	as	as	ADP
admet-257	43	30	muscle	muscle	NOUN
admet-257	43	31	aches	ache	NOUN
admet-257	43	32	,	,	PUNCT
admet-257	43	33	low	low	ADJ
admet-257	43	34	grade	grade	NOUN
admet-257	43	35	fever	fever	NOUN
admet-257	43	36	,	,	PUNCT
admet-257	43	37	and	and	CCONJ
admet-257	43	38	even	even	ADV
admet-257	43	39	psychological	psychological	ADJ
admet-257	43	40	manifestations	manifestation	NOUN
admet-257	43	41	that	that	PRON
admet-257	43	42	might	might	AUX
admet-257	43	43	be	be	AUX
admet-257	43	44	occurring	occur	VERB
admet-257	43	45	within	within	ADP
admet-257	43	46	the	the	DET
admet-257	43	47	animal	animal	NOUN
admet-257	43	48	even	even	ADV
admet-257	43	49	when	when	SCONJ
admet-257	43	50	being	be	AUX
admet-257	43	51	observed	observe	VERB
admet-257	43	52	[	[	X
admet-257	43	53	2	2	NUM
admet-257	43	54	]	]	PUNCT
admet-257	43	55	.	.	PUNCT
admet-257	44	1	hence	hence	ADV
admet-257	44	2	,	,	PUNCT
admet-257	44	3	it	it	PRON
admet-257	44	4	is	be	AUX
admet-257	44	5	imperative	imperative	ADJ
admet-257	44	6	that	that	SCONJ
admet-257	44	7	we	we	PRON
admet-257	44	8	improve	improve	VERB
admet-257	44	9	our	our	PRON
admet-257	44	10	skills	skill	NOUN
admet-257	44	11	in	in	ADP
admet-257	44	12	animal	animal	NOUN
admet-257	44	13	modelling	modelling	NOUN
admet-257	44	14	,	,	PUNCT
admet-257	44	15	test	test	NOUN
admet-257	44	16	design	design	NOUN
admet-257	44	17	,	,	PUNCT
admet-257	44	18	and	and	CCONJ
admet-257	44	19	effect	effect	NOUN
admet-257	44	20	recognition	recognition	NOUN
admet-257	44	21	,	,	PUNCT
admet-257	44	22	if	if	SCONJ
admet-257	44	23	we	we	PRON
admet-257	44	24	are	be	AUX
admet-257	44	25	to	to	PART
admet-257	44	26	attain	attain	VERB
admet-257	44	27	the	the	DET
admet-257	44	28	benefits	benefit	NOUN
admet-257	44	29	that	that	PRON
admet-257	44	30	animal	animal	NOUN
admet-257	44	31	testing	testing	NOUN
admet-257	44	32	can	can	AUX
admet-257	44	33	provide	provide	VERB
admet-257	44	34	.	.	PUNCT
admet-257	45	1	references	reference	NOUN
admet-257	45	2	[	[	X
admet-257	45	3	1	1	NUM
admet-257	45	4	]	]	PUNCT
admet-257	45	5	h.	h.	NOUN
admet-257	45	6	attarwala	attarwala	PROPN
admet-257	45	7	.	.	PUNCT
admet-257	46	1	j.	j.	PROPN
admet-257	46	2	young	young	PROPN
admet-257	46	3	pharm	pharm	PROPN
admet-257	46	4	.	.	PUNCT
admet-257	47	1	2(3	2(3	NUM
admet-257	47	2	)	)	PUNCT
admet-257	47	3	(	(	PUNCT
admet-257	47	4	2010	2010	NUM
admet-257	47	5	)	)	PUNCT
admet-257	47	6	332	332	NUM
admet-257	47	7	-	-	SYM
admet-257	47	8	336	336	NUM
admet-257	47	9	.	.	PUNCT
admet-257	48	1	[	[	X
admet-257	48	2	2	2	X
admet-257	48	3	]	]	X
admet-257	48	4	v.	v.	ADP
admet-257	48	5	baumans	bauman	NOUN
admet-257	48	6	.	.	PUNCT
admet-257	49	1	gene	gene	NOUN
admet-257	49	2	therapy	therapy	NOUN
admet-257	49	3	11	11	NUM
admet-257	49	4	(	(	PUNCT
admet-257	49	5	2004	2004	NUM
admet-257	49	6	)	)	PUNCT
admet-257	49	7	s64	s64	NOUN
admet-257	49	8	-	-	PUNCT
admet-257	49	9	s66	s66	NOUN
admet-257	49	10	.	.	PUNCT
admet-257	50	1	©	©	X
admet-257	50	2	2015	2015	NUM
admet-257	50	3	by	by	ADP
admet-257	50	4	the	the	DET
admet-257	50	5	authors	author	NOUN
admet-257	50	6	;	;	PUNCT
admet-257	50	7	licensee	licensee	PROPN
admet-257	50	8	iapc	iapc	PROPN
admet-257	50	9	,	,	PUNCT
admet-257	50	10	zagreb	zagreb	PROPN
admet-257	50	11	,	,	PUNCT
admet-257	50	12	croatia	croatia	PROPN
admet-257	50	13	.	.	PUNCT
admet-257	51	1	this	this	DET
admet-257	51	2	article	article	NOUN
admet-257	51	3	is	be	AUX
admet-257	51	4	an	an	DET
admet-257	51	5	open	open	ADJ
admet-257	51	6	-	-	PUNCT
admet-257	51	7	access	access	NOUN
admet-257	51	8	article	article	NOUN
admet-257	51	9	distributed	distribute	VERB
admet-257	51	10	under	under	ADP
admet-257	51	11	the	the	DET
admet-257	51	12	terms	term	NOUN
admet-257	51	13	and	and	CCONJ
admet-257	51	14	conditions	condition	NOUN
admet-257	51	15	of	of	ADP
admet-257	51	16	the	the	DET
admet-257	51	17	creative	creative	ADJ
admet-257	51	18	commons	common	NOUN
admet-257	51	19	attribution	attribution	NOUN
admet-257	51	20	license	license	NOUN
admet-257	51	21	(	(	PUNCT
admet-257	51	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-257	51	23	)	)	PUNCT
admet-257	51	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN