id	sid	tid	token	lemma	pos
admet-258	1	1	manuscript	manuscript	PROPN
admet-258	1	2	doi	doi	PROPN
admet-258	1	3	:	:	PUNCT
admet-258	1	4	10.5599	10.5599	NUM
admet-258	1	5	/	/	SYM
admet-258	1	6	admet.4.1.258	admet.4.1.258	PROPN
admet-258	1	7	35	35	NUM
admet-258	1	8	admet	admet	X
admet-258	1	9	&	&	CCONJ
admet-258	1	10	dmpk	dmpk	PROPN
admet-258	1	11	4(1	4(1	NOUN
admet-258	1	12	)	)	PUNCT
admet-258	1	13	(	(	PUNCT
admet-258	1	14	2016	2016	NUM
admet-258	1	15	)	)	PUNCT
admet-258	1	16	35	35	NUM
admet-258	1	17	-	-	SYM
admet-258	1	18	53	53	NUM
admet-258	1	19	;	;	PUNCT
admet-258	1	20	doi	doi	NOUN
admet-258	1	21	:	:	PUNCT
admet-258	1	22	10.5599	10.5599	NUM
admet-258	1	23	/	/	SYM
admet-258	1	24	admet.4.1.258	admet.4.1.258	NOUN
admet-258	1	25	open	open	ADJ
admet-258	1	26	access	access	NOUN
admet-258	1	27	:	:	PUNCT
admet-258	1	28	issn	issn	PROPN
admet-258	1	29	:	:	PUNCT
admet-258	1	30	1848	1848	NUM
admet-258	1	31	-	-	SYM
admet-258	1	32	7718	7718	NUM
admet-258	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-258	1	34	original	original	ADJ
admet-258	1	35	scientific	scientific	ADJ
admet-258	1	36	paper	paper	NOUN
admet-258	1	37	simulated	simulate	VERB
admet-258	1	38	rat	rat	NOUN
admet-258	1	39	intestinal	intestinal	ADJ
admet-258	1	40	fluid	fluid	NOUN
admet-258	1	41	improves	improve	VERB
admet-258	1	42	oral	oral	ADJ
admet-258	1	43	exposure	exposure	NOUN
admet-258	1	44	prediction	prediction	NOUN
admet-258	1	45	for	for	ADP
admet-258	1	46	poorly	poorly	ADV
admet-258	1	47	soluble	soluble	ADJ
admet-258	1	48	compounds	compound	NOUN
admet-258	1	49	over	over	ADP
admet-258	1	50	a	a	DET
admet-258	1	51	wide	wide	ADJ
admet-258	1	52	dose	dose	NOUN
admet-258	1	53	range	range	NOUN
admet-258	1	54	jörg	jörg	PROPN
admet-258	1	55	berghausen1	berghausen1	PROPN
admet-258	1	56	,	,	PUNCT
admet-258	1	57	*	*	PROPN
admet-258	1	58	,	,	PUNCT
admet-258	1	59	frank	frank	PROPN
admet-258	1	60	h.	h.	PROPN
admet-258	1	61	seiler2	seiler2	PROPN
admet-258	1	62	,	,	PUNCT
admet-258	1	63	nathalie	nathalie	PROPN
admet-258	1	64	gobeau1,3	gobeau1,3	PROPN
admet-258	1	65	and	and	CCONJ
admet-258	1	66	bernard	bernard	PROPN
admet-258	1	67	faller1	faller1	PROPN
admet-258	1	68	1	1	NUM
admet-258	1	69	novartis	novartis	NOUN
admet-258	1	70	institutes	institute	NOUN
admet-258	1	71	for	for	ADP
admet-258	1	72	biomedical	biomedical	ADJ
admet-258	1	73	research	research	NOUN
admet-258	1	74	,	,	PUNCT
admet-258	1	75	novartis	novartis	PROPN
admet-258	1	76	campus	campus	NOUN
admet-258	1	77	,	,	PUNCT
admet-258	1	78	ch-4002	ch-4002	NOUN
admet-258	1	79	basel	basel	PROPN
admet-258	1	80	2	2	NUM
admet-258	1	81	chemical	chemical	NOUN
admet-258	1	82	and	and	CCONJ
admet-258	1	83	pharmaceutical	pharmaceutical	NOUN
admet-258	1	84	profiling	profiling	NOUN
admet-258	1	85	,	,	PUNCT
admet-258	1	86	novartis	novartis	PROPN
admet-258	1	87	pharma	pharma	PROPN
admet-258	1	88	ag	ag	PROPN
admet-258	1	89	,	,	PUNCT
admet-258	1	90	novartis	novartis	PROPN
admet-258	1	91	campus	campus	NOUN
admet-258	1	92	,	,	PUNCT
admet-258	1	93	ch-4002	ch-4002	NOUN
admet-258	1	94	basel	basel	PROPN
admet-258	1	95	3	3	NUM
admet-258	1	96	current	current	ADJ
admet-258	1	97	address	address	NOUN
admet-258	1	98	:	:	PUNCT
admet-258	1	99	medicines	medicine	NOUN
admet-258	1	100	for	for	ADP
admet-258	1	101	malaria	malaria	NOUN
admet-258	1	102	venture	venture	NOUN
admet-258	1	103	,	,	PUNCT
admet-258	1	104	20	20	NUM
admet-258	1	105	,	,	PUNCT
admet-258	1	106	route	route	NOUN
admet-258	1	107	de	de	X
admet-258	1	108	pré	pré	PROPN
admet-258	1	109	-	-	NOUN
admet-258	1	110	bois	bois	NOUN
admet-258	1	111	,	,	PUNCT
admet-258	1	112	1215	1215	NUM
admet-258	1	113	geneva	geneva	PROPN
admet-258	1	114	15	15	NUM
admet-258	1	115	*	*	PUNCT
admet-258	1	116	corresponding	correspond	VERB
admet-258	1	117	author	author	NOUN
admet-258	1	118	:	:	PUNCT
admet-258	1	119	e	e	NOUN
admet-258	1	120	-	-	NOUN
admet-258	1	121	mail	mail	NOUN
admet-258	1	122	:	:	PUNCT
admet-258	1	123	joerg.berghausen@novartis.com	joerg.berghausen@novartis.com	X
admet-258	1	124	;	;	PUNCT
admet-258	1	125	tel	tel	PROPN
admet-258	1	126	.	.	PUNCT
admet-258	1	127	:	:	PUNCT
admet-258	2	1	+41	+41	NOUN
admet-258	2	2	61	61	NUM
admet-258	2	3	69	69	NUM
admet-258	2	4	62335	62335	NUM
admet-258	2	5	received	receive	VERB
admet-258	2	6	:	:	PUNCT
admet-258	2	7	november	november	PROPN
admet-258	2	8	18	18	NUM
admet-258	2	9	,	,	PUNCT
admet-258	2	10	2015	2015	NUM
admet-258	2	11	;	;	PUNCT
admet-258	2	12	revised	revise	VERB
admet-258	2	13	:	:	PUNCT
admet-258	2	14	march	march	PROPN
admet-258	2	15	12	12	NUM
admet-258	2	16	,	,	PUNCT
admet-258	2	17	2016	2016	NUM
admet-258	2	18	;	;	PUNCT
admet-258	2	19	published	publish	VERB
admet-258	2	20	:	:	PUNCT
admet-258	2	21	march	march	PROPN
admet-258	2	22	31	31	NUM
admet-258	2	23	,	,	PUNCT
admet-258	2	24	2016	2016	NUM
admet-258	2	25	abstract	abstract	ADJ
admet-258	2	26	solubility	solubility	NOUN
admet-258	2	27	can	can	AUX
admet-258	2	28	be	be	AUX
admet-258	2	29	the	the	DET
admet-258	2	30	absorption	absorption	NOUN
admet-258	2	31	limiting	limit	VERB
admet-258	2	32	factor	factor	NOUN
admet-258	2	33	for	for	ADP
admet-258	2	34	drug	drug	NOUN
admet-258	2	35	candidates	candidate	NOUN
admet-258	2	36	and	and	CCONJ
admet-258	2	37	is	be	AUX
admet-258	2	38	therefore	therefore	ADV
admet-258	2	39	a	a	DET
admet-258	2	40	very	very	ADV
admet-258	2	41	important	important	ADJ
admet-258	2	42	input	input	NOUN
admet-258	2	43	parameter	parameter	NOUN
admet-258	2	44	for	for	ADP
admet-258	2	45	oral	oral	ADJ
admet-258	2	46	exposure	exposure	NOUN
admet-258	2	47	prediction	prediction	NOUN
admet-258	2	48	of	of	ADP
admet-258	2	49	compounds	compound	NOUN
admet-258	2	50	with	with	ADP
admet-258	2	51	limited	limited	ADJ
admet-258	2	52	solubility	solubility	NOUN
admet-258	2	53	.	.	PUNCT
admet-258	3	1	biorelevant	biorelevant	ADJ
admet-258	3	2	media	medium	NOUN
admet-258	3	3	of	of	ADP
admet-258	3	4	the	the	DET
admet-258	3	5	fasted	fast	VERB
admet-258	3	6	and	and	CCONJ
admet-258	3	7	fed	fed	PROPN
admet-258	3	8	state	state	NOUN
admet-258	3	9	have	have	AUX
admet-258	3	10	been	be	AUX
admet-258	3	11	published	publish	VERB
admet-258	3	12	for	for	ADP
admet-258	3	13	humans	human	NOUN
admet-258	3	14	,	,	PUNCT
admet-258	3	15	as	as	ADV
admet-258	3	16	well	well	ADV
admet-258	3	17	as	as	ADP
admet-258	3	18	for	for	ADP
admet-258	3	19	dogs	dog	NOUN
admet-258	3	20	in	in	ADP
admet-258	3	21	the	the	DET
admet-258	3	22	fasted	fasted	ADJ
admet-258	3	23	state	state	NOUN
admet-258	3	24	.	.	PUNCT
admet-258	4	1	in	in	ADP
admet-258	4	2	a	a	DET
admet-258	4	3	drug	drug	NOUN
admet-258	4	4	discovery	discovery	NOUN
admet-258	4	5	environment	environment	NOUN
admet-258	4	6	,	,	PUNCT
admet-258	4	7	rodents	rodent	NOUN
admet-258	4	8	are	be	AUX
admet-258	4	9	the	the	DET
admet-258	4	10	most	most	ADV
admet-258	4	11	common	common	ADJ
admet-258	4	12	animal	animal	NOUN
admet-258	4	13	model	model	NOUN
admet-258	4	14	to	to	PART
admet-258	4	15	assess	assess	VERB
admet-258	4	16	the	the	DET
admet-258	4	17	oral	oral	ADJ
admet-258	4	18	exposure	exposure	NOUN
admet-258	4	19	of	of	ADP
admet-258	4	20	drug	drug	NOUN
admet-258	4	21	candidates	candidate	NOUN
admet-258	4	22	.	.	PUNCT
admet-258	5	1	in	in	ADP
admet-258	5	2	this	this	DET
admet-258	5	3	study	study	NOUN
admet-258	5	4	a	a	DET
admet-258	5	5	rat	rat	NOUN
admet-258	5	6	simulated	simulate	VERB
admet-258	5	7	intestinal	intestinal	ADJ
admet-258	5	8	fluid	fluid	NOUN
admet-258	5	9	(	(	PUNCT
admet-258	5	10	rsif	rsif	NOUN
admet-258	5	11	)	)	PUNCT
admet-258	5	12	is	be	AUX
admet-258	5	13	proposed	propose	VERB
admet-258	5	14	as	as	ADP
admet-258	5	15	a	a	DET
admet-258	5	16	more	more	ADV
admet-258	5	17	physiologically	physiologically	ADV
admet-258	5	18	relevant	relevant	ADJ
admet-258	5	19	media	medium	NOUN
admet-258	5	20	to	to	PART
admet-258	5	21	describe	describe	VERB
admet-258	5	22	drug	drug	NOUN
admet-258	5	23	solubility	solubility	NOUN
admet-258	5	24	in	in	ADP
admet-258	5	25	rats	rat	NOUN
admet-258	5	26	.	.	PUNCT
admet-258	6	1	equilibrium	equilibrium	NOUN
admet-258	6	2	solubility	solubility	NOUN
admet-258	6	3	in	in	ADP
admet-258	6	4	this	this	DET
admet-258	6	5	medium	medium	NOUN
admet-258	6	6	was	be	AUX
admet-258	6	7	tested	test	VERB
admet-258	6	8	as	as	ADP
admet-258	6	9	input	input	NOUN
admet-258	6	10	parameter	parameter	NOUN
admet-258	6	11	for	for	ADP
admet-258	6	12	physiologically	physiologically	ADV
admet-258	6	13	-	-	PUNCT
admet-258	6	14	based	base	VERB
admet-258	6	15	pharmacokinetics	pharmacokinetic	NOUN
admet-258	6	16	(	(	PUNCT
admet-258	6	17	pbpk	pbpk	NOUN
admet-258	6	18	)	)	PUNCT
admet-258	6	19	simulations	simulation	NOUN
admet-258	6	20	of	of	ADP
admet-258	6	21	oral	oral	ADJ
admet-258	6	22	pharmacokinetics	pharmacokinetic	NOUN
admet-258	6	23	in	in	ADP
admet-258	6	24	the	the	DET
admet-258	6	25	rat	rat	NOUN
admet-258	6	26	.	.	PUNCT
admet-258	6	27	simulations	simulation	NOUN
admet-258	6	28	were	be	AUX
admet-258	6	29	compared	compare	VERB
admet-258	6	30	to	to	ADP
admet-258	6	31	those	those	PRON
admet-258	6	32	obtained	obtain	VERB
admet-258	6	33	using	use	VERB
admet-258	6	34	other	other	ADJ
admet-258	6	35	solubility	solubility	NOUN
admet-258	6	36	values	value	NOUN
admet-258	6	37	as	as	ADP
admet-258	6	38	input	input	NOUN
admet-258	6	39	parameters	parameter	NOUN
admet-258	6	40	,	,	PUNCT
admet-258	6	41	like	like	ADP
admet-258	6	42	buffer	buffer	NOUN
admet-258	6	43	at	at	ADP
admet-258	6	44	ph	ph	ADJ
admet-258	6	45	6.8	6.8	NUM
admet-258	6	46	,	,	PUNCT
admet-258	6	47	human	human	ADJ
admet-258	6	48	simulated	simulate	VERB
admet-258	6	49	intestinal	intestinal	ADJ
admet-258	6	50	fluid	fluid	NOUN
admet-258	6	51	and	and	CCONJ
admet-258	6	52	a	a	DET
admet-258	6	53	comprehensive	comprehensive	ADJ
admet-258	6	54	dissolution	dissolution	NOUN
admet-258	6	55	assay	assay	NOUN
admet-258	6	56	based	base	VERB
admet-258	6	57	on	on	ADP
admet-258	6	58	rsif	rsif	NOUN
admet-258	6	59	.	.	PUNCT
admet-258	7	1	our	our	PRON
admet-258	7	2	study	study	NOUN
admet-258	7	3	on	on	ADP
admet-258	7	4	nine	nine	NUM
admet-258	7	5	different	different	ADJ
admet-258	7	6	compounds	compound	NOUN
admet-258	7	7	demonstrates	demonstrate	VERB
admet-258	7	8	that	that	SCONJ
admet-258	7	9	the	the	DET
admet-258	7	10	incorporation	incorporation	NOUN
admet-258	7	11	of	of	ADP
admet-258	7	12	rsif	rsif	PROPN
admet-258	7	13	equilibrium	equilibrium	NOUN
admet-258	7	14	solubility	solubility	NOUN
admet-258	7	15	values	value	NOUN
admet-258	7	16	into	into	ADP
admet-258	7	17	pbpk	pbpk	NOUN
admet-258	7	18	models	model	NOUN
admet-258	7	19	of	of	ADP
admet-258	7	20	oral	oral	ADJ
admet-258	7	21	drug	drug	NOUN
admet-258	7	22	exposure	exposure	NOUN
admet-258	7	23	can	can	AUX
admet-258	7	24	significantly	significantly	ADV
admet-258	7	25	improve	improve	VERB
admet-258	7	26	the	the	DET
admet-258	7	27	reliability	reliability	NOUN
admet-258	7	28	of	of	ADP
admet-258	7	29	simulations	simulation	NOUN
admet-258	7	30	in	in	ADP
admet-258	7	31	rats	rat	NOUN
admet-258	7	32	for	for	ADP
admet-258	7	33	doses	dose	NOUN
admet-258	7	34	up	up	ADP
admet-258	7	35	to	to	ADP
admet-258	7	36	300	300	NUM
admet-258	7	37	mg	mg	NOUN
admet-258	7	38	/	/	SYM
admet-258	7	39	kg	kg	PROPN
admet-258	7	40	compared	compare	VERB
admet-258	7	41	to	to	ADP
admet-258	7	42	other	other	ADJ
admet-258	7	43	media	medium	NOUN
admet-258	7	44	.	.	PUNCT
admet-258	8	1	the	the	DET
admet-258	8	2	comprehensive	comprehensive	ADJ
admet-258	8	3	dissolution	dissolution	NOUN
admet-258	8	4	assay	assay	NOUN
admet-258	8	5	may	may	AUX
admet-258	8	6	help	help	VERB
admet-258	8	7	to	to	PART
admet-258	8	8	improve	improve	VERB
admet-258	8	9	further	further	ADJ
admet-258	8	10	simulation	simulation	NOUN
admet-258	8	11	outcome	outcome	NOUN
admet-258	8	12	,	,	PUNCT
admet-258	8	13	but	but	CCONJ
admet-258	8	14	the	the	DET
admet-258	8	15	greater	great	ADJ
admet-258	8	16	experimental	experimental	ADJ
admet-258	8	17	effort	effort	NOUN
admet-258	8	18	as	as	SCONJ
admet-258	8	19	compared	compare	VERB
admet-258	8	20	to	to	ADP
admet-258	8	21	equilibrium	equilibrium	NOUN
admet-258	8	22	solubility	solubility	NOUN
admet-258	8	23	may	may	AUX
admet-258	8	24	limit	limit	VERB
admet-258	8	25	its	its	PRON
admet-258	8	26	use	use	NOUN
admet-258	8	27	in	in	ADP
admet-258	8	28	a	a	DET
admet-258	8	29	drug	drug	NOUN
admet-258	8	30	discovery	discovery	NOUN
admet-258	8	31	environment	environment	NOUN
admet-258	8	32	.	.	PUNCT
admet-258	9	1	overall	overall	ADV
admet-258	9	2	,	,	PUNCT
admet-258	9	3	pbpk	pbpk	ADJ
admet-258	9	4	simulations	simulation	NOUN
admet-258	9	5	based	base	VERB
admet-258	9	6	on	on	ADP
admet-258	9	7	solubility	solubility	NOUN
admet-258	9	8	in	in	ADP
admet-258	9	9	the	the	DET
admet-258	9	10	proposed	propose	VERB
admet-258	9	11	rsif	rsif	NOUN
admet-258	9	12	medium	medium	NOUN
admet-258	9	13	can	can	AUX
admet-258	9	14	improve	improve	VERB
admet-258	9	15	prioritizing	prioritize	VERB
admet-258	9	16	compounds	compound	NOUN
admet-258	9	17	in	in	ADP
admet-258	9	18	drug	drug	NOUN
admet-258	9	19	discovery	discovery	NOUN
admet-258	9	20	as	as	ADV
admet-258	9	21	well	well	ADV
admet-258	9	22	as	as	ADP
admet-258	9	23	planning	plan	VERB
admet-258	9	24	dose	dose	NOUN
admet-258	9	25	escalation	escalation	NOUN
admet-258	9	26	studies	study	NOUN
admet-258	9	27	,	,	PUNCT
admet-258	9	28	e.g.	e.g.	ADV
admet-258	9	29	during	during	ADP
admet-258	9	30	toxicological	toxicological	ADJ
admet-258	9	31	investigations	investigation	NOUN
admet-258	9	32	.	.	PUNCT
admet-258	10	1	keywords	keyword	VERB
admet-258	10	2	computational	computational	ADJ
admet-258	10	3	adme	adme	NOUN
admet-258	10	4	;	;	PUNCT
admet-258	10	5	preclinical	preclinical	ADJ
admet-258	10	6	pharmacokinetics	pharmacokinetic	NOUN
admet-258	10	7	;	;	PUNCT
admet-258	10	8	pbpk	pbpk	NOUN
admet-258	10	9	;	;	PUNCT
admet-258	10	10	modelling	modelling	NOUN
admet-258	10	11	;	;	PUNCT
admet-258	10	12	solubility	solubility	NOUN
admet-258	10	13	introduction	introduction	NOUN
admet-258	10	14	the	the	DET
admet-258	10	15	use	use	NOUN
admet-258	10	16	of	of	ADP
admet-258	10	17	physiologically	physiologically	ADV
admet-258	10	18	-	-	PUNCT
admet-258	10	19	based	base	VERB
admet-258	10	20	pharmacokinetic	pharmacokinetic	ADJ
admet-258	10	21	(	(	PUNCT
admet-258	10	22	pbpk	pbpk	NOUN
admet-258	10	23	)	)	PUNCT
admet-258	10	24	modeling	modeling	NOUN
admet-258	10	25	in	in	ADP
admet-258	10	26	drug	drug	NOUN
admet-258	10	27	development	development	NOUN
admet-258	10	28	has	have	AUX
admet-258	10	29	matured	mature	VERB
admet-258	10	30	and	and	CCONJ
admet-258	10	31	aims	aim	VERB
admet-258	10	32	at	at	ADP
admet-258	10	33	prediction	prediction	NOUN
admet-258	10	34	of	of	ADP
admet-258	10	35	plasma	plasma	NOUN
admet-258	10	36	-	-	PUNCT
admet-258	10	37	concentration	concentration	NOUN
admet-258	10	38	time	time	NOUN
admet-258	10	39	profiles	profile	NOUN
admet-258	10	40	based	base	VERB
admet-258	10	41	on	on	ADP
admet-258	10	42	both	both	PRON
admet-258	10	43	in	in	ADP
admet-258	10	44	silico	silico	NOUN
admet-258	10	45	and	and	CCONJ
admet-258	10	46	in	in	ADP
admet-258	10	47	vitro	vitro	X
admet-258	10	48	parameters	parameter	NOUN
admet-258	10	49	.	.	PUNCT
admet-258	11	1	regardless	regardless	ADV
admet-258	11	2	of	of	ADP
admet-258	11	3	the	the	DET
admet-258	11	4	advancement	advancement	NOUN
admet-258	11	5	of	of	ADP
admet-258	11	6	the	the	DET
admet-258	11	7	modeling	modeling	NOUN
admet-258	11	8	software	software	NOUN
admet-258	11	9	itself	itself	PRON
admet-258	11	10	,	,	PUNCT
admet-258	11	11	the	the	DET
admet-258	11	12	success	success	NOUN
admet-258	11	13	of	of	ADP
admet-258	11	14	pbpk	pbpk	NOUN
admet-258	11	15	approaches	approach	NOUN
admet-258	11	16	to	to	PART
admet-258	11	17	support	support	VERB
admet-258	11	18	decision	decision	NOUN
admet-258	11	19	making	making	NOUN
admet-258	11	20	will	will	AUX
admet-258	11	21	strongly	strongly	ADV
admet-258	11	22	depend	depend	VERB
admet-258	11	23	on	on	ADP
admet-258	11	24	the	the	DET
admet-258	11	25	use	use	NOUN
admet-258	11	26	of	of	ADP
admet-258	11	27	appropriate	appropriate	ADJ
admet-258	11	28	input	input	NOUN
admet-258	11	29	parameters	parameter	NOUN
admet-258	11	30	.	.	PUNCT
admet-258	12	1	this	this	PRON
admet-258	12	2	is	be	AUX
admet-258	12	3	particularly	particularly	ADV
admet-258	12	4	true	true	ADJ
admet-258	12	5	in	in	ADP
admet-258	12	6	drug	drug	NOUN
admet-258	12	7	discovery	discovery	NOUN
admet-258	12	8	,	,	PUNCT
admet-258	12	9	when	when	SCONJ
admet-258	12	10	the	the	DET
admet-258	12	11	robustness	robustness	NOUN
admet-258	12	12	of	of	ADP
admet-258	12	13	input	input	NOUN
admet-258	12	14	parameters	parameter	NOUN
admet-258	12	15	is	be	AUX
admet-258	12	16	naturally	naturally	ADV
admet-258	12	17	lower	low	ADJ
admet-258	12	18	compared	compare	VERB
admet-258	12	19	to	to	ADP
admet-258	12	20	data	datum	NOUN
admet-258	12	21	generated	generate	VERB
admet-258	12	22	in	in	ADP
admet-258	12	23	later	later	ADJ
admet-258	12	24	stage	stage	NOUN
admet-258	12	25	development	development	NOUN
admet-258	12	26	.	.	PUNCT
admet-258	13	1	a	a	DET
admet-258	13	2	recent	recent	ADJ
admet-258	13	3	overview	overview	NOUN
admet-258	13	4	on	on	ADP
admet-258	13	5	the	the	DET
admet-258	13	6	use	use	NOUN
admet-258	13	7	of	of	ADP
admet-258	13	8	pbpk	pbpk	NOUN
admet-258	13	9	models	model	NOUN
admet-258	13	10	for	for	ADP
admet-258	13	11	oral	oral	ADJ
admet-258	13	12	dosage	dosage	NOUN
admet-258	13	13	forms	form	NOUN
admet-258	13	14	is	be	AUX
admet-258	13	15	given	give	VERB
admet-258	13	16	by	by	ADP
admet-258	13	17	kostewicz	kostewicz	PROPN
admet-258	13	18	et	et	PROPN
admet-258	13	19	al	al	PROPN
admet-258	13	20	.	.	PUNCT
admet-258	14	1	[	[	X
admet-258	14	2	1	1	NUM
admet-258	14	3	]	]	PUNCT
admet-258	14	4	.	.	PUNCT
admet-258	15	1	many	many	ADJ
admet-258	15	2	reports	report	NOUN
admet-258	15	3	about	about	ADP
admet-258	15	4	its	its	PRON
admet-258	15	5	use	use	NOUN
admet-258	15	6	and	and	CCONJ
admet-258	15	7	years	year	NOUN
admet-258	15	8	of	of	ADP
admet-258	15	9	application	application	NOUN
admet-258	15	10	at	at	ADP
admet-258	15	11	various	various	ADJ
admet-258	15	12	stages	stage	NOUN
admet-258	15	13	of	of	ADP
admet-258	15	14	drug	drug	NOUN
admet-258	15	15	development	development	NOUN
admet-258	15	16	have	have	AUX
admet-258	15	17	generated	generate	VERB
admet-258	15	18	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-258	15	19	berghausen	berghausen	VERB
admet-258	15	20	et	et	PROPN
admet-258	15	21	al	al	PROPN
admet-258	15	22	.	.	PROPN
admet-258	15	23	admet	admet	PROPN
admet-258	15	24	&	&	CCONJ
admet-258	15	25	dmpk	dmpk	PROPN
admet-258	15	26	4(1	4(1	NOUN
admet-258	15	27	)	)	PUNCT
admet-258	15	28	(	(	PUNCT
admet-258	15	29	2016	2016	NUM
admet-258	15	30	)	)	PUNCT
admet-258	15	31	35	35	NUM
admet-258	15	32	-	-	SYM
admet-258	15	33	53	53	NUM
admet-258	15	34	36	36	NUM
admet-258	15	35	two	two	NUM
admet-258	15	36	main	main	ADJ
admet-258	15	37	strategies	strategy	NOUN
admet-258	15	38	for	for	ADP
admet-258	15	39	implementation	implementation	NOUN
admet-258	15	40	of	of	ADP
admet-258	15	41	pbpk	pbpk	NOUN
admet-258	15	42	in	in	ADP
admet-258	15	43	early	early	ADJ
admet-258	15	44	drug	drug	NOUN
admet-258	15	45	discovery	discovery	NOUN
admet-258	15	46	.	.	PUNCT
admet-258	16	1	on	on	ADP
admet-258	16	2	the	the	DET
admet-258	16	3	one	one	NUM
admet-258	16	4	hand	hand	NOUN
admet-258	16	5	simulation	simulation	NOUN
admet-258	16	6	approaches	approach	NOUN
admet-258	16	7	can	can	AUX
admet-258	16	8	be	be	AUX
admet-258	16	9	compared	compare	VERB
admet-258	16	10	to	to	ADP
admet-258	16	11	observed	observe	VERB
admet-258	16	12	data	datum	NOUN
admet-258	16	13	as	as	ADP
admet-258	16	14	a	a	DET
admet-258	16	15	strategy	strategy	NOUN
admet-258	16	16	to	to	PART
admet-258	16	17	build	build	VERB
admet-258	16	18	hypothesis	hypothesis	NOUN
admet-258	16	19	regarding	regard	VERB
admet-258	16	20	differences	difference	NOUN
admet-258	16	21	and	and	CCONJ
admet-258	16	22	sensitivity	sensitivity	NOUN
admet-258	16	23	of	of	ADP
admet-258	16	24	input	input	NOUN
admet-258	16	25	parameters	parameter	NOUN
admet-258	16	26	.	.	PUNCT
admet-258	17	1	to	to	PART
admet-258	17	2	prove	prove	VERB
admet-258	17	3	or	or	CCONJ
admet-258	17	4	disprove	disprove	VERB
admet-258	17	5	such	such	DET
admet-258	17	6	a	a	DET
admet-258	17	7	hypothesis	hypothesis	NOUN
admet-258	17	8	,	,	PUNCT
admet-258	17	9	results	result	NOUN
admet-258	17	10	may	may	AUX
admet-258	17	11	be	be	AUX
admet-258	17	12	used	use	VERB
admet-258	17	13	to	to	PART
admet-258	17	14	initiate	initiate	VERB
admet-258	17	15	further	further	ADJ
admet-258	17	16	studies	study	NOUN
admet-258	17	17	in	in	ADP
admet-258	17	18	order	order	NOUN
admet-258	17	19	to	to	PART
admet-258	17	20	identify	identify	VERB
admet-258	17	21	the	the	DET
admet-258	17	22	underlying	underlying	ADJ
admet-258	17	23	reason	reason	NOUN
admet-258	17	24	for	for	ADP
admet-258	17	25	discrepancies	discrepancy	NOUN
admet-258	17	26	between	between	ADP
admet-258	17	27	simulated	simulate	VERB
admet-258	17	28	and	and	CCONJ
admet-258	17	29	observed	observed	ADJ
admet-258	17	30	results	result	NOUN
admet-258	17	31	.	.	PUNCT
admet-258	18	1	another	another	DET
admet-258	18	2	strategy	strategy	NOUN
admet-258	18	3	is	be	AUX
admet-258	18	4	to	to	PART
admet-258	18	5	use	use	VERB
admet-258	18	6	pbpk	pbpk	ADJ
admet-258	18	7	approaches	approach	NOUN
admet-258	18	8	to	to	PART
admet-258	18	9	perform	perform	VERB
admet-258	18	10	pharmacokinetic	pharmacokinetic	ADJ
admet-258	18	11	prediction	prediction	NOUN
admet-258	18	12	across	across	ADP
admet-258	18	13	species	specie	NOUN
admet-258	18	14	,	,	PUNCT
admet-258	18	15	contributing	contribute	VERB
admet-258	18	16	to	to	ADP
admet-258	18	17	increased	increase	VERB
admet-258	18	18	confidence	confidence	NOUN
admet-258	18	19	in	in	ADP
admet-258	18	20	the	the	DET
admet-258	18	21	design	design	NOUN
admet-258	18	22	of	of	ADP
admet-258	18	23	preclinical	preclinical	ADJ
admet-258	18	24	toxicology	toxicology	NOUN
admet-258	18	25	studies	study	NOUN
admet-258	18	26	and	and	CCONJ
admet-258	18	27	ultimately	ultimately	ADV
admet-258	18	28	reliable	reliable	ADJ
admet-258	18	29	prediction	prediction	NOUN
admet-258	18	30	of	of	ADP
admet-258	18	31	human	human	ADJ
admet-258	18	32	pharmacokinetics	pharmacokinetic	NOUN
admet-258	18	33	.	.	PUNCT
admet-258	19	1	in	in	ADP
admet-258	19	2	order	order	NOUN
admet-258	19	3	for	for	ADP
admet-258	19	4	pbpk	pbpk	NOUN
admet-258	19	5	approaches	approach	NOUN
admet-258	19	6	to	to	PART
admet-258	19	7	have	have	VERB
admet-258	19	8	impact	impact	NOUN
admet-258	19	9	in	in	ADP
admet-258	19	10	a	a	DET
admet-258	19	11	drug	drug	NOUN
admet-258	19	12	discovery	discovery	NOUN
admet-258	19	13	setting	set	VERB
admet-258	19	14	we	we	PRON
admet-258	19	15	need	need	VERB
admet-258	19	16	to	to	PART
admet-258	19	17	be	be	AUX
admet-258	19	18	confident	confident	ADJ
admet-258	19	19	of	of	ADP
admet-258	19	20	performance	performance	NOUN
admet-258	19	21	reliability	reliability	NOUN
admet-258	19	22	.	.	PUNCT
admet-258	20	1	the	the	DET
admet-258	20	2	quality	quality	NOUN
admet-258	20	3	of	of	ADP
admet-258	20	4	pbpk	pbpk	NOUN
admet-258	20	5	simulations	simulation	NOUN
admet-258	20	6	during	during	ADP
admet-258	20	7	this	this	DET
admet-258	20	8	early	early	ADJ
admet-258	20	9	phase	phase	NOUN
admet-258	20	10	is	be	AUX
admet-258	20	11	often	often	ADV
admet-258	20	12	compromised	compromise	VERB
admet-258	20	13	by	by	ADP
admet-258	20	14	the	the	DET
admet-258	20	15	lack	lack	NOUN
admet-258	20	16	of	of	ADP
admet-258	20	17	validated	validated	ADJ
admet-258	20	18	input	input	NOUN
admet-258	20	19	data	datum	NOUN
admet-258	20	20	.	.	PUNCT
admet-258	21	1	there	there	PRON
admet-258	21	2	is	be	VERB
admet-258	21	3	greater	great	ADJ
admet-258	21	4	confidence	confidence	NOUN
admet-258	21	5	with	with	ADP
admet-258	21	6	human	human	ADJ
admet-258	21	7	pbpk	pbpk	NOUN
admet-258	21	8	prediction	prediction	NOUN
admet-258	21	9	based	base	VERB
admet-258	21	10	on	on	ADP
admet-258	21	11	the	the	DET
admet-258	21	12	fact	fact	NOUN
admet-258	21	13	that	that	SCONJ
admet-258	21	14	at	at	ADP
admet-258	21	15	this	this	DET
admet-258	21	16	stage	stage	NOUN
admet-258	21	17	of	of	ADP
admet-258	21	18	drug	drug	NOUN
admet-258	21	19	development	development	NOUN
admet-258	21	20	,	,	PUNCT
admet-258	21	21	a	a	DET
admet-258	21	22	broad	broad	ADJ
admet-258	21	23	set	set	NOUN
admet-258	21	24	of	of	ADP
admet-258	21	25	robust	robust	ADJ
admet-258	21	26	input	input	NOUN
admet-258	21	27	data	datum	NOUN
admet-258	21	28	is	be	AUX
admet-258	21	29	available	available	ADJ
admet-258	21	30	.	.	PUNCT
admet-258	22	1	in	in	ADP
admet-258	22	2	addition	addition	NOUN
admet-258	22	3	,	,	PUNCT
admet-258	22	4	many	many	ADJ
admet-258	22	5	aspects	aspect	NOUN
admet-258	22	6	of	of	ADP
admet-258	22	7	human	human	ADJ
admet-258	22	8	physiology	physiology	NOUN
admet-258	22	9	have	have	AUX
admet-258	22	10	been	be	AUX
admet-258	22	11	studied	study	VERB
admet-258	22	12	in	in	ADP
admet-258	22	13	much	much	ADV
admet-258	22	14	greater	great	ADJ
admet-258	22	15	detail	detail	NOUN
admet-258	22	16	compared	compare	VERB
admet-258	22	17	to	to	ADP
admet-258	22	18	preclinical	preclinical	ADJ
admet-258	22	19	species	specie	NOUN
admet-258	22	20	.	.	PUNCT
admet-258	23	1	although	although	SCONJ
admet-258	23	2	rodents	rodent	NOUN
admet-258	23	3	,	,	PUNCT
admet-258	23	4	especially	especially	ADV
admet-258	23	5	rats	rat	NOUN
admet-258	23	6	,	,	PUNCT
admet-258	23	7	are	be	AUX
admet-258	23	8	still	still	ADV
admet-258	23	9	the	the	DET
admet-258	23	10	most	most	ADV
admet-258	23	11	relevant	relevant	ADJ
admet-258	23	12	screening	screening	NOUN
admet-258	23	13	model	model	NOUN
admet-258	23	14	in	in	ADP
admet-258	23	15	drug	drug	NOUN
admet-258	23	16	discovery	discovery	NOUN
admet-258	23	17	,	,	PUNCT
admet-258	23	18	many	many	ADJ
admet-258	23	19	parameters	parameter	NOUN
admet-258	23	20	relevant	relevant	ADJ
admet-258	23	21	for	for	ADP
admet-258	23	22	drug	drug	NOUN
admet-258	23	23	adme	adme	NOUN
admet-258	23	24	properties	property	NOUN
admet-258	23	25	are	be	AUX
admet-258	23	26	not	not	PART
admet-258	23	27	known	know	VERB
admet-258	23	28	in	in	ADP
admet-258	23	29	detail	detail	NOUN
admet-258	23	30	or	or	CCONJ
admet-258	23	31	show	show	VERB
admet-258	23	32	a	a	DET
admet-258	23	33	high	high	ADJ
admet-258	23	34	variability	variability	NOUN
admet-258	23	35	.	.	PUNCT
admet-258	24	1	even	even	ADV
admet-258	24	2	within	within	ADP
admet-258	24	3	one	one	NUM
admet-258	24	4	defined	define	VERB
admet-258	24	5	rat	rat	NOUN
admet-258	24	6	strain	strain	NOUN
admet-258	24	7	,	,	PUNCT
admet-258	24	8	a	a	DET
admet-258	24	9	broad	broad	ADJ
admet-258	24	10	range	range	NOUN
admet-258	24	11	of	of	ADP
admet-258	24	12	values	value	NOUN
admet-258	24	13	is	be	AUX
admet-258	24	14	typically	typically	ADV
admet-258	24	15	reported	report	VERB
admet-258	24	16	in	in	ADP
admet-258	24	17	the	the	DET
admet-258	24	18	literature	literature	NOUN
admet-258	24	19	[	[	X
admet-258	24	20	2,3	2,3	NUM
admet-258	24	21	]	]	PUNCT
admet-258	24	22	.	.	PUNCT
admet-258	25	1	it	it	PRON
admet-258	25	2	is	be	AUX
admet-258	25	3	clear	clear	ADJ
admet-258	25	4	that	that	SCONJ
admet-258	25	5	solubility	solubility	NOUN
admet-258	25	6	can	can	AUX
admet-258	25	7	play	play	VERB
admet-258	25	8	a	a	DET
admet-258	25	9	major	major	ADJ
admet-258	25	10	role	role	NOUN
admet-258	25	11	in	in	ADP
admet-258	25	12	the	the	DET
admet-258	25	13	drug	drug	NOUN
admet-258	25	14	absorption	absorption	NOUN
admet-258	25	15	process	process	NOUN
admet-258	25	16	,	,	PUNCT
admet-258	25	17	particularly	particularly	ADV
admet-258	25	18	when	when	SCONJ
admet-258	25	19	dealing	deal	VERB
admet-258	25	20	with	with	ADP
admet-258	25	21	poorly	poorly	ADV
admet-258	25	22	soluble	soluble	ADJ
admet-258	25	23	compounds	compound	NOUN
admet-258	25	24	.	.	PUNCT
admet-258	26	1	as	as	SCONJ
admet-258	26	2	the	the	DET
admet-258	26	3	majority	majority	NOUN
admet-258	26	4	of	of	ADP
admet-258	26	5	compounds	compound	NOUN
admet-258	26	6	in	in	ADP
admet-258	26	7	current	current	ADJ
admet-258	26	8	research	research	NOUN
admet-258	26	9	pipelines	pipeline	NOUN
admet-258	26	10	of	of	ADP
admet-258	26	11	pharmaceutical	pharmaceutical	NOUN
admet-258	26	12	industry	industry	NOUN
admet-258	26	13	are	be	AUX
admet-258	26	14	classified	classify	VERB
admet-258	26	15	into	into	ADP
admet-258	26	16	the	the	DET
admet-258	26	17	bcs	bcs	NOUN
admet-258	26	18	class	class	NOUN
admet-258	26	19	ii	ii	PROPN
admet-258	26	20	category	category	NOUN
admet-258	26	21	[	[	X
admet-258	26	22	4	4	NUM
admet-258	26	23	]	]	PUNCT
admet-258	26	24	,	,	PUNCT
admet-258	26	25	i.e.	i.e.	X
admet-258	26	26	drug	drug	NOUN
admet-258	26	27	absorption	absorption	NOUN
admet-258	26	28	is	be	AUX
admet-258	26	29	limited	limit	VERB
admet-258	26	30	by	by	ADP
admet-258	26	31	solubility	solubility	NOUN
admet-258	26	32	,	,	PUNCT
admet-258	26	33	it	it	PRON
admet-258	26	34	is	be	AUX
admet-258	26	35	very	very	ADV
admet-258	26	36	important	important	ADJ
admet-258	26	37	to	to	PART
admet-258	26	38	assess	assess	VERB
admet-258	26	39	the	the	DET
admet-258	26	40	development	development	NOUN
admet-258	26	41	risk	risk	NOUN
admet-258	26	42	of	of	ADP
admet-258	26	43	such	such	ADJ
admet-258	26	44	drug	drug	NOUN
admet-258	26	45	candidates	candidate	NOUN
admet-258	26	46	at	at	ADP
admet-258	26	47	a	a	DET
admet-258	26	48	very	very	ADV
admet-258	26	49	early	early	ADJ
admet-258	26	50	stage	stage	NOUN
admet-258	26	51	of	of	ADP
admet-258	26	52	the	the	DET
admet-258	26	53	process	process	NOUN
admet-258	26	54	when	when	SCONJ
admet-258	26	55	choices	choice	NOUN
admet-258	26	56	among	among	ADP
admet-258	26	57	different	different	ADJ
admet-258	26	58	chemical	chemical	NOUN
admet-258	26	59	structures	structure	NOUN
admet-258	26	60	are	be	AUX
admet-258	26	61	still	still	ADV
admet-258	26	62	possible	possible	ADJ
admet-258	26	63	.	.	PUNCT
admet-258	27	1	in	in	ADP
admet-258	27	2	order	order	NOUN
admet-258	27	3	to	to	PART
admet-258	27	4	provide	provide	VERB
admet-258	27	5	pbpk	pbpk	PROPN
admet-258	27	6	simulation	simulation	NOUN
admet-258	27	7	software	software	NOUN
admet-258	27	8	with	with	ADP
admet-258	27	9	better	well	ADJ
admet-258	27	10	solubility	solubility	NOUN
admet-258	27	11	input	input	NOUN
admet-258	27	12	parameters	parameter	NOUN
admet-258	27	13	,	,	PUNCT
admet-258	27	14	the	the	DET
admet-258	27	15	use	use	NOUN
admet-258	27	16	of	of	ADP
admet-258	27	17	solubility	solubility	NOUN
admet-258	27	18	values	value	NOUN
admet-258	27	19	in	in	ADP
admet-258	27	20	human	human	ADJ
admet-258	27	21	fassif	fassif	NOUN
admet-258	27	22	(	(	PUNCT
admet-258	27	23	fasted	fast	VERB
admet-258	27	24	-	-	PUNCT
admet-258	27	25	state	state	NOUN
admet-258	27	26	simulated	simulate	VERB
admet-258	27	27	intestinal	intestinal	ADJ
admet-258	27	28	fluid	fluid	NOUN
admet-258	27	29	)	)	PUNCT
admet-258	27	30	has	have	AUX
admet-258	27	31	been	be	AUX
admet-258	27	32	proposed	propose	VERB
admet-258	27	33	before	before	ADV
admet-258	27	34	.	.	PUNCT
admet-258	28	1	many	many	ADJ
admet-258	28	2	publications	publication	NOUN
admet-258	28	3	refer	refer	VERB
admet-258	28	4	to	to	ADP
admet-258	28	5	human	human	ADJ
admet-258	28	6	pk	pk	NOUN
admet-258	28	7	prediction	prediction	NOUN
admet-258	28	8	[	[	X
admet-258	28	9	5	5	NUM
admet-258	28	10	]	]	PUNCT
admet-258	28	11	,	,	PUNCT
admet-258	28	12	but	but	CCONJ
admet-258	28	13	fassif	fassif	NOUN
admet-258	28	14	has	have	AUX
admet-258	28	15	been	be	AUX
admet-258	28	16	proposed	propose	VERB
admet-258	28	17	as	as	ADP
admet-258	28	18	input	input	NOUN
admet-258	28	19	parameters	parameter	NOUN
admet-258	28	20	for	for	ADP
admet-258	28	21	rats	rat	NOUN
admet-258	28	22	,	,	PUNCT
admet-258	28	23	too	too	ADV
admet-258	29	1	[	[	X
admet-258	29	2	6	6	NUM
admet-258	29	3	]	]	PUNCT
admet-258	29	4	.	.	PUNCT
admet-258	30	1	as	as	SCONJ
admet-258	30	2	rats	rat	NOUN
admet-258	30	3	are	be	AUX
admet-258	30	4	lacking	lack	VERB
admet-258	30	5	a	a	DET
admet-258	30	6	gall	gall	NOUN
admet-258	30	7	bladder	bladder	NOUN
admet-258	30	8	,	,	PUNCT
admet-258	30	9	their	their	PRON
admet-258	30	10	gi	gi	NOUN
admet-258	30	11	tract	tract	NOUN
admet-258	30	12	is	be	AUX
admet-258	30	13	exposed	expose	VERB
admet-258	30	14	to	to	ADP
admet-258	30	15	a	a	DET
admet-258	30	16	constant	constant	ADJ
admet-258	30	17	bile	bile	NOUN
admet-258	30	18	flow	flow	NOUN
admet-258	30	19	at	at	ADP
admet-258	30	20	concentrations	concentration	NOUN
admet-258	30	21	higher	high	ADJ
admet-258	30	22	than	than	ADP
admet-258	30	23	in	in	ADP
admet-258	30	24	any	any	DET
admet-258	30	25	other	other	ADJ
admet-258	30	26	typical	typical	ADJ
admet-258	30	27	preclinical	preclinical	ADJ
admet-258	30	28	species	specie	NOUN
admet-258	30	29	.	.	PUNCT
admet-258	31	1	reported	report	VERB
admet-258	31	2	bile	bile	NOUN
admet-258	31	3	salt	salt	NOUN
admet-258	31	4	concentrations	concentration	NOUN
admet-258	31	5	in	in	ADP
admet-258	31	6	rats	rat	NOUN
admet-258	31	7	are	be	AUX
admet-258	31	8	in	in	ADP
admet-258	31	9	the	the	DET
admet-258	31	10	range	range	NOUN
admet-258	31	11	of	of	ADP
admet-258	31	12	12	12	NUM
admet-258	31	13	-	-	SYM
admet-258	31	14	51	51	NUM
admet-258	31	15	mm	mm	NOUN
admet-258	32	1	[	[	X
admet-258	32	2	7	7	NUM
admet-258	32	3	-	-	SYM
admet-258	32	4	9	9	NUM
admet-258	32	5	]	]	PUNCT
admet-258	32	6	.	.	PUNCT
admet-258	33	1	human	human	PROPN
admet-258	33	2	bio	bio	PROPN
admet-258	33	3	-	-	ADJ
admet-258	33	4	relevant	relevant	ADJ
admet-258	33	5	fluids	fluid	NOUN
admet-258	33	6	are	be	AUX
admet-258	33	7	undoubtedly	undoubtedly	ADV
admet-258	33	8	relevant	relevant	ADJ
admet-258	33	9	dissolution	dissolution	NOUN
admet-258	33	10	media	medium	NOUN
admet-258	33	11	in	in	ADP
admet-258	33	12	order	order	NOUN
admet-258	33	13	to	to	PART
admet-258	33	14	assess	assess	VERB
admet-258	33	15	the	the	DET
admet-258	33	16	performance	performance	NOUN
admet-258	33	17	of	of	ADP
admet-258	33	18	drug	drug	NOUN
admet-258	33	19	candidates	candidate	NOUN
admet-258	33	20	in	in	ADP
admet-258	33	21	a	a	DET
admet-258	33	22	clinical	clinical	ADJ
admet-258	33	23	research	research	NOUN
admet-258	33	24	and	and	CCONJ
admet-258	33	25	development	development	NOUN
admet-258	33	26	environment	environment	NOUN
admet-258	33	27	.	.	PUNCT
admet-258	34	1	however	however	ADV
admet-258	34	2	,	,	PUNCT
admet-258	34	3	the	the	DET
admet-258	34	4	decision	decision	NOUN
admet-258	34	5	to	to	PART
admet-258	34	6	move	move	VERB
admet-258	34	7	a	a	DET
admet-258	34	8	potential	potential	ADJ
admet-258	34	9	drug	drug	NOUN
admet-258	34	10	candidate	candidate	NOUN
admet-258	34	11	forward	forward	ADV
admet-258	34	12	is	be	AUX
admet-258	34	13	taken	take	VERB
admet-258	34	14	during	during	ADP
admet-258	34	15	the	the	DET
admet-258	34	16	pre	pre	ADJ
admet-258	34	17	-	-	ADJ
admet-258	34	18	clinical	clinical	ADJ
admet-258	34	19	phase	phase	NOUN
admet-258	34	20	.	.	PUNCT
admet-258	35	1	up	up	ADP
admet-258	35	2	to	to	ADP
admet-258	35	3	the	the	DET
admet-258	35	4	point	point	NOUN
admet-258	35	5	of	of	ADP
admet-258	35	6	compound	compound	NOUN
admet-258	35	7	selection	selection	NOUN
admet-258	35	8	for	for	ADP
admet-258	35	9	clinical	clinical	ADJ
admet-258	35	10	development	development	NOUN
admet-258	35	11	,	,	PUNCT
admet-258	35	12	these	these	DET
admet-258	35	13	compounds	compound	NOUN
admet-258	35	14	have	have	AUX
admet-258	35	15	only	only	ADV
admet-258	35	16	been	be	AUX
admet-258	35	17	tested	test	VERB
admet-258	35	18	in	in	ADP
admet-258	35	19	typical	typical	ADJ
admet-258	35	20	preclinical	preclinical	ADJ
admet-258	35	21	species	specie	NOUN
admet-258	35	22	,	,	PUNCT
admet-258	35	23	like	like	ADP
admet-258	35	24	rats	rat	NOUN
admet-258	35	25	,	,	PUNCT
admet-258	35	26	dogs	dog	NOUN
admet-258	35	27	,	,	PUNCT
admet-258	35	28	monkeys	monkey	NOUN
admet-258	35	29	or	or	CCONJ
admet-258	35	30	minipigs	minipig	NOUN
admet-258	35	31	.	.	PUNCT
admet-258	36	1	the	the	DET
admet-258	36	2	role	role	NOUN
admet-258	36	3	of	of	ADP
admet-258	36	4	solubility	solubility	NOUN
admet-258	36	5	in	in	ADP
admet-258	36	6	the	the	DET
admet-258	36	7	gastrointestinal	gastrointestinal	ADJ
admet-258	36	8	tract	tract	NOUN
admet-258	36	9	of	of	ADP
admet-258	36	10	a	a	DET
admet-258	36	11	particular	particular	ADJ
admet-258	36	12	species	specie	NOUN
admet-258	36	13	becomes	become	VERB
admet-258	36	14	evident	evident	ADJ
admet-258	36	15	,	,	PUNCT
admet-258	36	16	as	as	ADV
admet-258	36	17	soon	soon	ADV
admet-258	36	18	as	as	SCONJ
admet-258	36	19	a	a	DET
admet-258	36	20	compound	compound	NOUN
admet-258	36	21	of	of	ADP
admet-258	36	22	low	low	ADJ
admet-258	36	23	solubility	solubility	NOUN
admet-258	36	24	has	have	AUX
admet-258	36	25	shown	show	VERB
admet-258	36	26	reasonable	reasonable	ADJ
admet-258	36	27	pk	pk	NOUN
admet-258	36	28	parameters	parameter	NOUN
admet-258	36	29	in	in	ADP
admet-258	36	30	rodents	rodent	NOUN
admet-258	36	31	and	and	CCONJ
admet-258	36	32	is	be	AUX
admet-258	36	33	selected	select	VERB
admet-258	36	34	for	for	ADP
admet-258	36	35	testing	testing	NOUN
admet-258	36	36	of	of	ADP
admet-258	36	37	pk	pk	NOUN
admet-258	36	38	properties	property	NOUN
admet-258	36	39	in	in	ADP
admet-258	36	40	a	a	DET
admet-258	36	41	non	non	ADJ
admet-258	36	42	-	-	ADJ
admet-258	36	43	rodent	rodent	ADJ
admet-258	36	44	species	specie	NOUN
admet-258	36	45	.	.	PUNCT
admet-258	37	1	potentially	potentially	ADV
admet-258	37	2	,	,	PUNCT
admet-258	37	3	solubility	solubility	NOUN
admet-258	37	4	may	may	AUX
admet-258	37	5	be	be	AUX
admet-258	37	6	one	one	NUM
admet-258	37	7	of	of	ADP
admet-258	37	8	the	the	DET
admet-258	37	9	main	main	ADJ
admet-258	37	10	factors	factor	NOUN
admet-258	37	11	that	that	PRON
admet-258	37	12	limit	limit	VERB
admet-258	37	13	human	human	ADJ
admet-258	37	14	bioavailability	bioavailability	NOUN
admet-258	37	15	prediction	prediction	NOUN
admet-258	37	16	based	base	VERB
admet-258	37	17	on	on	ADP
admet-258	37	18	animal	animal	NOUN
admet-258	37	19	studies	study	NOUN
admet-258	37	20	[	[	X
admet-258	37	21	10	10	NUM
admet-258	37	22	]	]	PUNCT
admet-258	37	23	,	,	PUNCT
admet-258	37	24	in	in	SCONJ
admet-258	37	25	case	case	NOUN
admet-258	37	26	solubility	solubility	NOUN
admet-258	37	27	in	in	ADP
admet-258	37	28	human	human	ADJ
admet-258	37	29	gi	gi	NOUN
admet-258	37	30	fluids	fluid	NOUN
admet-258	37	31	is	be	AUX
admet-258	37	32	significantly	significantly	ADV
admet-258	37	33	lower	low	ADJ
admet-258	37	34	than	than	ADP
admet-258	37	35	in	in	ADP
admet-258	37	36	gi	gi	NOUN
admet-258	37	37	fluids	fluid	NOUN
admet-258	37	38	of	of	ADP
admet-258	37	39	preclinical	preclinical	ADJ
admet-258	37	40	species	specie	NOUN
admet-258	37	41	.	.	PUNCT
admet-258	38	1	solubilization	solubilization	NOUN
admet-258	38	2	of	of	ADP
admet-258	38	3	compounds	compound	NOUN
admet-258	38	4	in	in	ADP
admet-258	38	5	the	the	DET
admet-258	38	6	gi	gi	NOUN
admet-258	38	7	fluids	fluid	NOUN
admet-258	38	8	is	be	AUX
admet-258	38	9	mainly	mainly	ADV
admet-258	38	10	driven	drive	VERB
admet-258	38	11	by	by	ADP
admet-258	38	12	bile	bile	NOUN
admet-258	38	13	salt	salt	NOUN
admet-258	38	14	and	and	CCONJ
admet-258	38	15	phospholipid	phospholipid	NOUN
admet-258	38	16	contents	content	NOUN
admet-258	38	17	.	.	PUNCT
admet-258	39	1	to	to	ADP
admet-258	39	2	what	what	DET
admet-258	39	3	extent	extent	NOUN
admet-258	39	4	differences	difference	NOUN
admet-258	39	5	in	in	ADP
admet-258	39	6	fluid	fluid	ADJ
admet-258	39	7	composition	composition	NOUN
admet-258	39	8	influence	influence	NOUN
admet-258	39	9	solubility	solubility	NOUN
admet-258	39	10	across	across	ADP
admet-258	39	11	species	specie	NOUN
admet-258	39	12	has	have	AUX
admet-258	39	13	been	be	AUX
admet-258	39	14	demonstrated	demonstrate	VERB
admet-258	39	15	in	in	ADP
admet-258	39	16	a	a	DET
admet-258	39	17	comparison	comparison	NOUN
admet-258	39	18	of	of	ADP
admet-258	39	19	solubility	solubility	NOUN
admet-258	39	20	of	of	ADP
admet-258	39	21	drug	drug	NOUN
admet-258	39	22	molecules	molecule	NOUN
admet-258	39	23	in	in	ADP
admet-258	39	24	human	human	ADJ
admet-258	39	25	and	and	CCONJ
admet-258	39	26	dog	dog	NOUN
admet-258	39	27	gi	gi	NOUN
admet-258	39	28	fluids	fluid	NOUN
admet-258	39	29	[	[	X
admet-258	39	30	11	11	NUM
admet-258	39	31	]	]	PUNCT
admet-258	39	32	.	.	PUNCT
admet-258	40	1	for	for	ADP
admet-258	40	2	this	this	DET
admet-258	40	3	reason	reason	NOUN
admet-258	40	4	,	,	PUNCT
admet-258	40	5	the	the	DET
admet-258	40	6	impact	impact	NOUN
admet-258	40	7	of	of	ADP
admet-258	40	8	solubility	solubility	NOUN
admet-258	40	9	on	on	ADP
admet-258	40	10	pbpk	pbpk	PROPN
admet-258	40	11	simulation	simulation	NOUN
admet-258	40	12	results	result	NOUN
admet-258	40	13	has	have	AUX
admet-258	40	14	been	be	AUX
admet-258	40	15	widely	widely	ADV
admet-258	40	16	studied	study	VERB
admet-258	40	17	,	,	PUNCT
admet-258	40	18	especially	especially	ADV
admet-258	40	19	the	the	DET
admet-258	40	20	use	use	NOUN
admet-258	40	21	of	of	ADP
admet-258	40	22	high	high	ADJ
admet-258	40	23	-	-	PUNCT
admet-258	40	24	throughput	throughput	NOUN
admet-258	40	25	vs.	vs.	ADP
admet-258	40	26	thermodynamic	thermodynamic	ADJ
admet-258	40	27	equilibrium	equilibrium	NOUN
admet-258	40	28	solubility	solubility	NOUN
admet-258	40	29	data	datum	NOUN
admet-258	40	30	.	.	PUNCT
admet-258	41	1	gao	gao	PROPN
admet-258	41	2	et	et	PROPN
admet-258	41	3	al	al	PROPN
admet-258	41	4	.	.	PUNCT
admet-258	42	1	[	[	X
admet-258	42	2	6	6	NUM
admet-258	42	3	]	]	PUNCT
admet-258	42	4	have	have	AUX
admet-258	42	5	described	describe	VERB
admet-258	42	6	a	a	DET
admet-258	42	7	way	way	NOUN
admet-258	42	8	to	to	PART
admet-258	42	9	generate	generate	VERB
admet-258	42	10	solubility	solubility	NOUN
admet-258	42	11	input	input	NOUN
admet-258	42	12	parameters	parameter	NOUN
admet-258	42	13	for	for	ADP
admet-258	42	14	pbpk	pbpk	NOUN
admet-258	42	15	simulations	simulation	NOUN
admet-258	42	16	of	of	ADP
admet-258	42	17	rats	rat	NOUN
admet-258	42	18	by	by	ADP
admet-258	42	19	applying	apply	VERB
admet-258	42	20	a	a	DET
admet-258	42	21	full	full	ADJ
admet-258	42	22	gi	gi	NOUN
admet-258	42	23	dissolution	dissolution	NOUN
admet-258	42	24	profile	profile	NOUN
admet-258	42	25	that	that	PRON
admet-258	42	26	takes	take	VERB
admet-258	42	27	into	into	ADP
admet-258	42	28	consideration	consideration	NOUN
admet-258	42	29	the	the	DET
admet-258	42	30	constant	constant	ADJ
admet-258	42	31	dilution	dilution	NOUN
admet-258	42	32	by	by	ADP
admet-258	42	33	fluid	fluid	ADJ
admet-258	42	34	secretion	secretion	NOUN
admet-258	42	35	along	along	ADP
admet-258	42	36	the	the	DET
admet-258	42	37	gi	gi	NOUN
admet-258	42	38	transit	transit	NOUN
admet-258	42	39	,	,	PUNCT
admet-258	42	40	as	as	ADV
admet-258	42	41	well	well	ADV
admet-258	42	42	as	as	ADP
admet-258	42	43	formulation	formulation	NOUN
admet-258	42	44	options	option	NOUN
admet-258	42	45	admet	admet	X
admet-258	42	46	&	&	CCONJ
admet-258	42	47	dmpk	dmpk	PROPN
admet-258	42	48	4(1	4(1	NOUN
admet-258	42	49	)	)	PUNCT
admet-258	42	50	(	(	PUNCT
admet-258	42	51	2016	2016	NUM
admet-258	42	52	)	)	PUNCT
admet-258	42	53	35	35	NUM
admet-258	42	54	-	-	SYM
admet-258	42	55	53	53	NUM
admet-258	42	56	simulated	simulate	VERB
admet-258	42	57	rat	rat	NOUN
admet-258	42	58	intestinal	intestinal	ADJ
admet-258	42	59	fluid	fluid	ADJ
admet-258	42	60	doi	doi	NOUN
admet-258	42	61	:	:	PUNCT
admet-258	42	62	10.5599	10.5599	NUM
admet-258	42	63	/	/	SYM
admet-258	42	64	admet.4.1.258	admet.4.1.258	PROPN
admet-258	42	65	37	37	NUM
admet-258	42	66	that	that	PRON
admet-258	42	67	could	could	AUX
admet-258	42	68	lead	lead	VERB
admet-258	42	69	to	to	ADP
admet-258	42	70	differences	difference	NOUN
admet-258	42	71	in	in	ADP
admet-258	42	72	supersaturation	supersaturation	NOUN
admet-258	42	73	and	and	CCONJ
admet-258	42	74	re	re	NOUN
admet-258	42	75	-	-	NOUN
admet-258	42	76	precipitation	precipitation	ADJ
admet-258	42	77	behavior	behavior	NOUN
admet-258	42	78	.	.	PUNCT
admet-258	43	1	however	however	ADV
admet-258	43	2	,	,	PUNCT
admet-258	43	3	their	their	PRON
admet-258	43	4	model	model	NOUN
admet-258	43	5	is	be	AUX
admet-258	43	6	based	base	VERB
admet-258	43	7	on	on	ADP
admet-258	43	8	human	human	ADJ
admet-258	43	9	fassif	fassif	NOUN
admet-258	43	10	to	to	PART
admet-258	43	11	mimic	mimic	VERB
admet-258	43	12	the	the	DET
admet-258	43	13	dilution	dilution	NOUN
admet-258	43	14	in	in	ADP
admet-258	43	15	the	the	DET
admet-258	43	16	rat	rat	NOUN
admet-258	43	17	gi	gi	NOUN
admet-258	43	18	fluid	fluid	NOUN
admet-258	43	19	.	.	PUNCT
admet-258	44	1	due	due	ADP
admet-258	44	2	to	to	ADP
admet-258	44	3	the	the	DET
admet-258	44	4	sensitivity	sensitivity	NOUN
admet-258	44	5	of	of	ADP
admet-258	44	6	solubility	solubility	NOUN
admet-258	44	7	to	to	ADP
admet-258	44	8	bile	bile	NOUN
admet-258	44	9	salts	salt	NOUN
admet-258	44	10	,	,	PUNCT
admet-258	44	11	which	which	PRON
admet-258	44	12	is	be	AUX
admet-258	44	13	expected	expect	VERB
admet-258	44	14	for	for	ADP
admet-258	44	15	many	many	ADJ
admet-258	44	16	compounds	compound	NOUN
admet-258	44	17	in	in	ADP
admet-258	44	18	drug	drug	NOUN
admet-258	44	19	discovery	discovery	NOUN
admet-258	44	20	,	,	PUNCT
admet-258	44	21	solubility	solubility	NOUN
admet-258	44	22	tested	test	VERB
admet-258	44	23	in	in	ADP
admet-258	44	24	the	the	DET
admet-258	44	25	proposed	propose	VERB
admet-258	44	26	simulated	simulate	VERB
admet-258	44	27	rat	rat	NOUN
admet-258	44	28	fluid	fluid	NOUN
admet-258	44	29	should	should	AUX
admet-258	44	30	improve	improve	VERB
admet-258	44	31	the	the	DET
admet-258	44	32	prediction	prediction	NOUN
admet-258	44	33	power	power	NOUN
admet-258	44	34	of	of	ADP
admet-258	44	35	pbpk	pbpk	ADJ
admet-258	44	36	simulations	simulation	NOUN
admet-258	44	37	when	when	SCONJ
admet-258	44	38	rodents	rodent	NOUN
admet-258	44	39	are	be	AUX
admet-258	44	40	the	the	DET
admet-258	44	41	species	specie	NOUN
admet-258	44	42	of	of	ADP
admet-258	44	43	interest	interest	NOUN
admet-258	44	44	.	.	PUNCT
admet-258	45	1	in	in	ADP
admet-258	45	2	this	this	DET
admet-258	45	3	publication	publication	NOUN
admet-258	45	4	,	,	PUNCT
admet-258	45	5	we	we	PRON
admet-258	45	6	describe	describe	VERB
admet-258	45	7	a	a	DET
admet-258	45	8	way	way	NOUN
admet-258	45	9	to	to	PART
admet-258	45	10	generate	generate	VERB
admet-258	45	11	a	a	DET
admet-258	45	12	simulated	simulated	ADJ
admet-258	45	13	rat	rat	NOUN
admet-258	45	14	intestinal	intestinal	ADJ
admet-258	45	15	fluid	fluid	NOUN
admet-258	45	16	(	(	PUNCT
admet-258	45	17	rsif	rsif	NOUN
admet-258	45	18	)	)	PUNCT
admet-258	45	19	and	and	CCONJ
admet-258	45	20	study	study	VERB
admet-258	45	21	its	its	PRON
admet-258	45	22	impact	impact	NOUN
admet-258	45	23	on	on	ADP
admet-258	45	24	pbpk	pbpk	ADJ
admet-258	45	25	simulation	simulation	NOUN
admet-258	45	26	for	for	ADP
admet-258	45	27	rats	rat	NOUN
admet-258	45	28	.	.	PUNCT
admet-258	46	1	the	the	DET
admet-258	46	2	results	result	NOUN
admet-258	46	3	are	be	AUX
admet-258	46	4	compared	compare	VERB
admet-258	46	5	to	to	ADP
admet-258	46	6	simulations	simulation	NOUN
admet-258	46	7	which	which	PRON
admet-258	46	8	use	use	VERB
admet-258	46	9	other	other	ADJ
admet-258	46	10	solubility	solubility	NOUN
admet-258	46	11	input	input	NOUN
admet-258	46	12	values	value	NOUN
admet-258	46	13	,	,	PUNCT
admet-258	46	14	like	like	SCONJ
admet-258	46	15	solubility	solubility	NOUN
admet-258	46	16	in	in	ADP
admet-258	46	17	buffer	buffer	NOUN
admet-258	46	18	ph	ph	VERB
admet-258	46	19	6.8	6.8	NUM
admet-258	46	20	,	,	PUNCT
admet-258	46	21	fassif	fassif	NOUN
admet-258	46	22	and	and	CCONJ
admet-258	46	23	the	the	DET
admet-258	46	24	dissolution	dissolution	NOUN
admet-258	46	25	curve	curve	NOUN
admet-258	46	26	generated	generate	VERB
admet-258	46	27	by	by	ADP
admet-258	46	28	an	an	DET
admet-258	46	29	in	in	X
admet-258	46	30	vitro	vitro	X
admet-258	46	31	gi	gi	X
admet-258	46	32	dissolution	dissolution	PROPN
admet-258	46	33	assay	assay	PROPN
admet-258	47	1	[	[	X
admet-258	47	2	6	6	NUM
admet-258	47	3	]	]	PUNCT
admet-258	47	4	.	.	PUNCT
admet-258	48	1	in	in	ADP
admet-258	48	2	addition	addition	NOUN
admet-258	48	3	,	,	PUNCT
admet-258	48	4	bile	bile	NOUN
admet-258	48	5	salt	salt	NOUN
admet-258	48	6	dependent	dependent	ADJ
admet-258	48	7	solubility	solubility	NOUN
admet-258	48	8	estimated	estimate	VERB
admet-258	48	9	based	base	VERB
admet-258	48	10	on	on	ADP
admet-258	48	11	log	log	PROPN
admet-258	48	12	p	p	NOUN
admet-258	48	13	is	be	AUX
admet-258	48	14	included	include	VERB
admet-258	48	15	in	in	ADP
admet-258	48	16	this	this	DET
admet-258	48	17	comparison	comparison	NOUN
admet-258	48	18	[	[	X
admet-258	48	19	12	12	NUM
admet-258	48	20	]	]	PUNCT
admet-258	48	21	.	.	PUNCT
admet-258	49	1	materials	material	NOUN
admet-258	49	2	and	and	CCONJ
admet-258	49	3	methods	method	NOUN
admet-258	49	4	physico	physico	NOUN
admet-258	49	5	-	-	PUNCT
admet-258	49	6	chemical	chemical	NOUN
admet-258	49	7	measurements	measurement	NOUN
admet-258	49	8	passive	passive	ADJ
admet-258	49	9	permeability	permeability	NOUN
admet-258	49	10	of	of	ADP
admet-258	49	11	the	the	DET
admet-258	49	12	compounds	compound	NOUN
admet-258	49	13	was	be	AUX
admet-258	49	14	investigated	investigate	VERB
admet-258	49	15	using	use	VERB
admet-258	49	16	the	the	DET
admet-258	49	17	pampa	pampa	NOUN
admet-258	49	18	assay	assay	VERB
admet-258	50	1	[	[	X
admet-258	50	2	13	13	NUM
admet-258	50	3	]	]	PUNCT
admet-258	50	4	.	.	PUNCT
admet-258	51	1	in	in	ADP
admet-258	51	2	the	the	DET
admet-258	51	3	current	current	ADJ
admet-258	51	4	work	work	NOUN
admet-258	51	5	,	,	PUNCT
admet-258	51	6	the	the	DET
admet-258	51	7	log	log	NOUN
admet-258	51	8	pampa	pampa	NOUN
admet-258	51	9	value	value	NOUN
admet-258	51	10	has	have	AUX
admet-258	51	11	been	be	AUX
admet-258	51	12	used	use	VERB
admet-258	51	13	,	,	PUNCT
admet-258	51	14	which	which	PRON
admet-258	51	15	represents	represent	VERB
admet-258	51	16	the	the	DET
admet-258	51	17	highest	high	ADJ
admet-258	51	18	value	value	NOUN
admet-258	51	19	of	of	ADP
admet-258	51	20	effective	effective	ADJ
admet-258	51	21	permeability	permeability	NOUN
admet-258	51	22	from	from	ADP
admet-258	51	23	three	three	NUM
admet-258	51	24	measured	measured	ADJ
admet-258	51	25	values	value	NOUN
admet-258	51	26	at	at	ADP
admet-258	51	27	ph	ph	PROPN
admet-258	51	28	4	4	NUM
admet-258	51	29	,	,	PUNCT
admet-258	51	30	ph	ph	X
admet-258	51	31	6.8	6.8	NUM
admet-258	51	32	and	and	CCONJ
admet-258	51	33	ph	ph	ADJ
admet-258	51	34	8	8	NUM
admet-258	51	35	.	.	PUNCT
admet-258	52	1	equilibrium	equilibrium	NOUN
admet-258	52	2	solubility	solubility	NOUN
admet-258	52	3	was	be	AUX
admet-258	52	4	determined	determine	VERB
admet-258	52	5	using	use	VERB
admet-258	52	6	the	the	DET
admet-258	52	7	shake	shake	NOUN
admet-258	52	8	-	-	PUNCT
admet-258	52	9	flask	flask	NOUN
admet-258	52	10	method	method	NOUN
admet-258	52	11	using	use	VERB
admet-258	52	12	about	about	ADP
admet-258	52	13	1.5	1.5	NUM
admet-258	52	14	mg	mg	NOUN
admet-258	52	15	of	of	ADP
admet-258	52	16	compound	compound	NOUN
admet-258	52	17	.	.	PUNCT
admet-258	53	1	the	the	DET
admet-258	53	2	mixture	mixture	NOUN
admet-258	53	3	was	be	AUX
admet-258	53	4	shaken	shake	VERB
admet-258	53	5	for	for	ADP
admet-258	53	6	20	20	NUM
admet-258	53	7	to	to	PART
admet-258	53	8	24	24	NUM
admet-258	53	9	hours	hour	NOUN
admet-258	53	10	and	and	CCONJ
admet-258	53	11	the	the	DET
admet-258	53	12	solid	solid	ADJ
admet-258	53	13	phase	phase	NOUN
admet-258	53	14	was	be	AUX
admet-258	53	15	separated	separate	VERB
admet-258	53	16	by	by	ADP
admet-258	53	17	centrifugation	centrifugation	NOUN
admet-258	53	18	for	for	ADP
admet-258	53	19	15	15	NUM
admet-258	53	20	min	min	NOUN
admet-258	53	21	at	at	ADP
admet-258	53	22	2000	2000	NUM
admet-258	53	23	g.	g.	NOUN
admet-258	53	24	concentration	concentration	NOUN
admet-258	53	25	of	of	ADP
admet-258	53	26	the	the	DET
admet-258	53	27	compound	compound	NOUN
admet-258	53	28	in	in	ADP
admet-258	53	29	the	the	DET
admet-258	53	30	supernatant	supernatant	NOUN
admet-258	53	31	was	be	AUX
admet-258	53	32	determined	determine	VERB
admet-258	53	33	by	by	ADP
admet-258	53	34	hplc	hplc	PROPN
admet-258	53	35	-	-	PUNCT
admet-258	53	36	uv	uv	PROPN
admet-258	53	37	(	(	PUNCT
admet-258	53	38	agilent	agilent	PROPN
admet-258	53	39	1200	1200	NUM
admet-258	53	40	)	)	PUNCT
admet-258	53	41	based	base	VERB
admet-258	53	42	on	on	ADP
admet-258	53	43	an	an	DET
admet-258	53	44	external	external	ADJ
admet-258	53	45	calibration	calibration	NOUN
admet-258	53	46	curve	curve	NOUN
admet-258	53	47	.	.	PUNCT
admet-258	54	1	the	the	DET
admet-258	54	2	partition	partition	NOUN
admet-258	54	3	coefficient	coefficient	NOUN
admet-258	54	4	log	log	NOUN
admet-258	54	5	p	p	NOUN
admet-258	54	6	was	be	AUX
admet-258	54	7	determined	determine	VERB
admet-258	54	8	for	for	ADP
admet-258	54	9	ionizable	ionizable	ADJ
admet-258	54	10	compounds	compound	NOUN
admet-258	54	11	by	by	ADP
admet-258	54	12	potentiometric	potentiometric	ADJ
admet-258	54	13	titration	titration	NOUN
admet-258	54	14	(	(	PUNCT
admet-258	54	15	sirius	sirius	PROPN
admet-258	54	16	t3	t3	PROPN
admet-258	54	17	,	,	PUNCT
admet-258	54	18	sirius	sirius	PROPN
admet-258	54	19	instruments	instruments	PROPN
admet-258	54	20	ltd	ltd	PROPN
admet-258	54	21	.	.	PROPN
admet-258	54	22	)	)	PUNCT
admet-258	54	23	.	.	PUNCT
admet-258	55	1	non	non	ADJ
admet-258	55	2	-	-	ADJ
admet-258	55	3	ionizable	ionizable	ADJ
admet-258	55	4	compounds	compound	NOUN
admet-258	55	5	were	be	AUX
admet-258	55	6	analyzed	analyze	VERB
admet-258	55	7	by	by	ADP
admet-258	55	8	reverse	reverse	NOUN
admet-258	55	9	-	-	PUNCT
admet-258	55	10	phase	phase	NOUN
admet-258	55	11	hplc	hplc	NOUN
admet-258	55	12	.	.	PUNCT
admet-258	56	1	determination	determination	NOUN
admet-258	56	2	of	of	ADP
admet-258	56	3	the	the	DET
admet-258	56	4	acid	acid	PROPN
admet-258	56	5	dissociation	dissociation	NOUN
admet-258	56	6	constant	constant	ADJ
admet-258	56	7	(	(	PUNCT
admet-258	56	8	pka	pka	NOUN
admet-258	56	9	)	)	PUNCT
admet-258	56	10	was	be	AUX
admet-258	56	11	done	do	VERB
admet-258	56	12	by	by	ADP
admet-258	56	13	potentiometric	potentiometric	ADJ
admet-258	56	14	titration	titration	NOUN
admet-258	56	15	(	(	PUNCT
admet-258	56	16	sirius	sirius	PROPN
admet-258	56	17	t3	t3	PROPN
admet-258	56	18	,	,	PUNCT
admet-258	56	19	sirius	sirius	PROPN
admet-258	56	20	instruments	instruments	PROPN
admet-258	56	21	ltd	ltd	PROPN
admet-258	56	22	.	.	PUNCT
admet-258	56	23	)	)	PUNCT
admet-258	56	24	.	.	PUNCT
admet-258	57	1	preparation	preparation	NOUN
admet-258	57	2	of	of	ADP
admet-258	57	3	test	test	NOUN
admet-258	57	4	media	medium	NOUN
admet-258	57	5	buffer	buffer	NOUN
admet-258	57	6	solution	solution	NOUN
admet-258	57	7	from	from	ADP
admet-258	57	8	merck	merck	PROPN
admet-258	57	9	kgaa	kgaa	PROPN
admet-258	57	10	;	;	PUNCT
admet-258	57	11	ph	ph	NOUN
admet-258	57	12	6.8	6.8	NUM
admet-258	57	13	;	;	PUNCT
admet-258	57	14	0.1	0.1	NUM
admet-258	57	15	m	m	NOUN
admet-258	57	16	di	di	NOUN
admet-258	57	17	-	-	PUNCT
admet-258	57	18	sodium	sodium	NOUN
admet-258	57	19	hydrogen	hydrogen	NOUN
admet-258	57	20	phosphate	phosphate	NOUN
admet-258	57	21	/	/	SYM
admet-258	57	22	potassium	potassium	NOUN
admet-258	57	23	hydrogen	hydrogen	NOUN
admet-258	57	24	phosphate	phosphate	NOUN
admet-258	57	25	was	be	AUX
admet-258	57	26	used	use	VERB
admet-258	57	27	.	.	PUNCT
admet-258	58	1	preparation	preparation	NOUN
admet-258	58	2	of	of	ADP
admet-258	58	3	human	human	ADJ
admet-258	58	4	fassif	fassif	NOUN
admet-258	58	5	-	-	PUNCT
admet-258	58	6	v2	v2	PROPN
admet-258	58	7	was	be	AUX
admet-258	58	8	done	do	VERB
admet-258	58	9	based	base	VERB
admet-258	58	10	on	on	ADP
admet-258	58	11	the	the	DET
admet-258	58	12	suggestion	suggestion	NOUN
admet-258	58	13	by	by	ADP
admet-258	58	14	jantratid	jantratid	PROPN
admet-258	58	15	et	et	PROPN
admet-258	58	16	al	al	PROPN
admet-258	58	17	.	.	PUNCT
admet-258	59	1	[	[	X
admet-258	59	2	14	14	NUM
admet-258	59	3	]	]	PUNCT
admet-258	59	4	.	.	PUNCT
admet-258	60	1	to	to	PART
admet-258	60	2	obtain	obtain	VERB
admet-258	60	3	one	one	NUM
admet-258	60	4	liter	liter	NOUN
admet-258	60	5	of	of	ADP
admet-258	60	6	clear	clear	ADJ
admet-258	60	7	fassif	fassif	NOUN
admet-258	60	8	-	-	PUNCT
admet-258	60	9	v2	v2	NOUN
admet-258	60	10	,	,	PUNCT
admet-258	60	11	sodium	sodium	NOUN
admet-258	60	12	taurocholate	taurocholate	NOUN
admet-258	60	13	and	and	CCONJ
admet-258	60	14	sodium	sodium	NOUN
admet-258	60	15	chloride	chloride	NOUN
admet-258	60	16	were	be	AUX
admet-258	60	17	first	first	ADV
admet-258	60	18	dissolved	dissolve	VERB
admet-258	60	19	in	in	ADP
admet-258	60	20	400	400	NUM
admet-258	60	21	ml	ml	NOUN
admet-258	60	22	of	of	ADP
admet-258	60	23	purified	purified	ADJ
admet-258	60	24	water	water	NOUN
admet-258	60	25	,	,	PUNCT
admet-258	60	26	followed	follow	VERB
admet-258	60	27	by	by	ADP
admet-258	60	28	the	the	DET
admet-258	60	29	addition	addition	NOUN
admet-258	60	30	of	of	ADP
admet-258	60	31	1	1	NUM
admet-258	60	32	ml	ml	NOUN
admet-258	60	33	of	of	ADP
admet-258	60	34	1	1	NUM
admet-258	60	35	m	m	NOUN
admet-258	60	36	hcl	hcl	PROPN
admet-258	60	37	.	.	PUNCT
admet-258	61	1	after	after	ADP
admet-258	61	2	stirring	stir	VERB
admet-258	61	3	for	for	ADP
admet-258	61	4	30	30	NUM
admet-258	61	5	min	min	NOUN
admet-258	61	6	,	,	PUNCT
admet-258	61	7	lecithin	lecithin	NOUN
admet-258	61	8	was	be	AUX
admet-258	61	9	added	add	VERB
admet-258	61	10	and	and	CCONJ
admet-258	61	11	the	the	DET
admet-258	61	12	mixture	mixture	NOUN
admet-258	61	13	was	be	AUX
admet-258	61	14	sonicated	sonicate	VERB
admet-258	61	15	until	until	ADP
admet-258	61	16	complete	complete	ADJ
admet-258	61	17	dissolution	dissolution	NOUN
admet-258	61	18	and	and	CCONJ
admet-258	61	19	stirred	stir	VERB
admet-258	61	20	for	for	ADP
admet-258	61	21	another	another	DET
admet-258	61	22	two	two	NUM
admet-258	61	23	hours	hour	NOUN
admet-258	61	24	.	.	PUNCT
admet-258	62	1	then	then	ADV
admet-258	62	2	,	,	PUNCT
admet-258	62	3	maleic	maleic	ADJ
admet-258	62	4	acid	acid	NOUN
admet-258	62	5	and	and	CCONJ
admet-258	62	6	500	500	NUM
admet-258	62	7	ml	ml	NOUN
admet-258	62	8	of	of	ADP
admet-258	62	9	water	water	NOUN
admet-258	62	10	were	be	AUX
admet-258	62	11	added	add	VERB
admet-258	62	12	.	.	PUNCT
admet-258	63	1	after	after	ADP
admet-258	63	2	overnight	overnight	ADJ
admet-258	63	3	stirring	stirring	NOUN
admet-258	63	4	,	,	PUNCT
admet-258	63	5	the	the	DET
admet-258	63	6	ph	ph	NOUN
admet-258	63	7	was	be	AUX
admet-258	63	8	adjusted	adjust	VERB
admet-258	63	9	to	to	ADP
admet-258	63	10	6.5	6.5	NUM
admet-258	63	11	by	by	ADP
admet-258	63	12	addition	addition	NOUN
admet-258	63	13	of	of	ADP
admet-258	63	14	1	1	NUM
admet-258	63	15	m	m	NOUN
admet-258	63	16	naoh	naoh	NOUN
admet-258	63	17	and	and	CCONJ
admet-258	63	18	the	the	DET
admet-258	63	19	total	total	ADJ
admet-258	63	20	volume	volume	NOUN
admet-258	63	21	was	be	AUX
admet-258	63	22	adjusted	adjust	VERB
admet-258	63	23	to	to	ADP
admet-258	63	24	1	1	NUM
admet-258	63	25	l.	l.	NOUN
admet-258	63	26	simulated	simulate	VERB
admet-258	63	27	rat	rat	NOUN
admet-258	63	28	intestinal	intestinal	ADJ
admet-258	63	29	fluid	fluid	NOUN
admet-258	63	30	a	a	DET
admet-258	63	31	rat	rat	NOUN
admet-258	63	32	simulating	simulate	VERB
admet-258	63	33	intestinal	intestinal	ADJ
admet-258	63	34	fluid	fluid	NOUN
admet-258	63	35	(	(	PUNCT
admet-258	63	36	rsif	rsif	NOUN
admet-258	63	37	)	)	PUNCT
admet-258	63	38	was	be	AUX
admet-258	63	39	developed	develop	VERB
admet-258	63	40	as	as	ADP
admet-258	63	41	surrogate	surrogate	ADJ
admet-258	63	42	to	to	PART
admet-258	63	43	mimic	mimic	VERB
admet-258	63	44	intestinal	intestinal	ADJ
admet-258	63	45	conditions	condition	NOUN
admet-258	63	46	in	in	ADP
admet-258	63	47	vivo	vivo	NOUN
admet-258	63	48	with	with	ADP
admet-258	63	49	regard	regard	NOUN
admet-258	63	50	to	to	ADP
admet-258	63	51	bile	bile	NOUN
admet-258	63	52	salt	salt	NOUN
admet-258	63	53	and	and	CCONJ
admet-258	63	54	phospholipid	phospholipid	NOUN
admet-258	63	55	concentrations	concentration	NOUN
admet-258	63	56	,	,	PUNCT
admet-258	64	1	surface	surface	NOUN
admet-258	64	2	tension	tension	NOUN
admet-258	64	3	,	,	PUNCT
admet-258	64	4	ph	ph	ADJ
admet-258	64	5	,	,	PUNCT
admet-258	64	6	buffer	buffer	NOUN
admet-258	64	7	capacity	capacity	NOUN
admet-258	64	8	and	and	CCONJ
admet-258	64	9	osmolarity	osmolarity	NOUN
admet-258	64	10	[	[	X
admet-258	64	11	15	15	NUM
admet-258	64	12	]	]	PUNCT
admet-258	64	13	.	.	PUNCT
admet-258	65	1	this	this	PRON
admet-258	65	2	was	be	AUX
admet-258	65	3	done	do	VERB
admet-258	65	4	to	to	PART
admet-258	65	5	supplement	supplement	VERB
admet-258	65	6	previously	previously	ADV
admet-258	65	7	published	publish	VERB
admet-258	65	8	human	human	NOUN
admet-258	65	9	[	[	X
admet-258	65	10	14	14	NUM
admet-258	65	11	]	]	PUNCT
admet-258	65	12	and	and	CCONJ
admet-258	65	13	canine	canine	VERB
admet-258	66	1	[	[	X
admet-258	66	2	11	11	NUM
admet-258	66	3	]	]	PUNCT
admet-258	66	4	media	medium	NOUN
admet-258	66	5	.	.	PUNCT
admet-258	67	1	due	due	ADP
admet-258	67	2	to	to	ADP
admet-258	67	3	unavailability	unavailability	NOUN
admet-258	67	4	of	of	ADP
admet-258	67	5	sufficient	sufficient	ADJ
admet-258	67	6	ex	ex	PRON
admet-258	67	7	vivo	vivo	NOUN
admet-258	67	8	samples	sample	NOUN
admet-258	67	9	,	,	PUNCT
admet-258	67	10	published	publish	VERB
admet-258	67	11	information	information	NOUN
admet-258	67	12	was	be	AUX
admet-258	67	13	used	use	VERB
admet-258	67	14	to	to	PART
admet-258	67	15	define	define	VERB
admet-258	67	16	the	the	DET
admet-258	67	17	target	target	NOUN
admet-258	67	18	properties	property	NOUN
admet-258	67	19	of	of	ADP
admet-258	67	20	rsif	rsif	NOUN
admet-258	67	21	.	.	PUNCT
admet-258	68	1	table	table	NOUN
admet-258	68	2	1	1	NUM
admet-258	68	3	compares	compare	VERB
admet-258	68	4	the	the	DET
admet-258	68	5	main	main	ADJ
admet-258	68	6	properties	property	NOUN
admet-258	68	7	of	of	ADP
admet-258	68	8	rsif	rsif	NOUN
admet-258	68	9	with	with	ADP
admet-258	68	10	human	human	ADJ
admet-258	68	11	fassif	fassif	NOUN
admet-258	68	12	-	-	PUNCT
admet-258	68	13	v2	v2	NOUN
admet-258	68	14	.	.	PUNCT
admet-258	69	1	berghausen	berghausen	PROPN
admet-258	69	2	et	et	PROPN
admet-258	69	3	al	al	PROPN
admet-258	69	4	.	.	PROPN
admet-258	69	5	admet	admet	PROPN
admet-258	69	6	&	&	CCONJ
admet-258	69	7	dmpk	dmpk	PROPN
admet-258	69	8	4(1	4(1	NOUN
admet-258	69	9	)	)	PUNCT
admet-258	69	10	(	(	PUNCT
admet-258	69	11	2016	2016	NUM
admet-258	69	12	)	)	PUNCT
admet-258	69	13	35	35	NUM
admet-258	69	14	-	-	SYM
admet-258	69	15	53	53	NUM
admet-258	69	16	38	38	NUM
admet-258	69	17	table	table	NOUN
admet-258	69	18	1	1	NUM
admet-258	69	19	.	.	PUNCT
admet-258	69	20	main	main	ADJ
admet-258	69	21	properties	property	NOUN
admet-258	69	22	of	of	ADP
admet-258	69	23	rat	rat	NOUN
admet-258	69	24	simulated	simulate	VERB
admet-258	69	25	intestinal	intestinal	ADJ
admet-258	69	26	fluid	fluid	NOUN
admet-258	69	27	(	(	PUNCT
admet-258	69	28	rsif	rsif	NOUN
admet-258	69	29	)	)	PUNCT
admet-258	69	30	in	in	ADP
admet-258	69	31	comparison	comparison	NOUN
admet-258	69	32	to	to	ADP
admet-258	69	33	human	human	ADJ
admet-258	69	34	fassif	fassif	NOUN
admet-258	69	35	-	-	PUNCT
admet-258	69	36	v2	v2	NOUN
admet-258	69	37	rsif	rsif	NOUN
admet-258	69	38	fassif	fassif	NOUN
admet-258	69	39	-	-	PUNCT
admet-258	69	40	v2	v2	NOUN
admet-258	69	41	ph	ph	ADJ
admet-258	69	42	6.0	6.0	NUM
admet-258	69	43	6.5	6.5	NUM
admet-258	69	44	buffer	buffer	NOUN
admet-258	69	45	capacity	capacity	NOUN
admet-258	69	46	[	[	X
admet-258	69	47	mmol	mmol	NOUN
admet-258	69	48	/	/	SYM
admet-258	69	49	l	l	NOUN
admet-258	69	50	/	/	SYM
admet-258	69	51	ph	ph	ADJ
admet-258	69	52	]	]	X
admet-258	69	53	15.2	15.2	NUM
admet-258	69	54	10	10	NUM
admet-258	69	55	surface	surface	NOUN
admet-258	69	56	tension	tension	NOUN
admet-258	69	57	[	[	X
admet-258	69	58	mn	mn	PROPN
admet-258	69	59	/	/	SYM
admet-258	69	60	m	m	PROPN
admet-258	69	61	]	]	X
admet-258	69	62	42	42	NUM
admet-258	69	63	54.3	54.3	NUM
admet-258	69	64	osmolality	osmolality	NOUN
admet-258	69	65	[	[	X
admet-258	69	66	mosmol	mosmol	PROPN
admet-258	69	67	/	/	SYM
admet-258	69	68	kg	kg	X
admet-258	69	69	]	]	X
admet-258	69	70	480	480	NUM
admet-258	69	71	180	180	NUM
admet-258	69	72	bile	bile	NOUN
admet-258	69	73	salt	salt	NOUN
admet-258	69	74	concentration	concentration	NOUN
admet-258	69	75	[	[	X
admet-258	69	76	mm	mm	X
admet-258	69	77	]	]	X
admet-258	69	78	25	25	NUM
admet-258	69	79	3	3	NUM
admet-258	69	80	phospholipid	phospholipid	NOUN
admet-258	69	81	concentration	concentration	NOUN
admet-258	70	1	[	[	X
admet-258	70	2	mm	mm	X
admet-258	70	3	]	]	X
admet-258	70	4	5.16	5.16	NUM
admet-258	70	5	0.2	0.2	NUM
admet-258	70	6	due	due	ADP
admet-258	70	7	to	to	ADP
admet-258	70	8	the	the	DET
admet-258	70	9	constant	constant	ADJ
admet-258	70	10	bile	bile	NOUN
admet-258	70	11	flow	flow	NOUN
admet-258	70	12	in	in	ADP
admet-258	70	13	rats	rat	NOUN
admet-258	70	14	due	due	ADP
admet-258	70	15	to	to	ADP
admet-258	70	16	a	a	DET
admet-258	70	17	lack	lack	NOUN
admet-258	70	18	of	of	ADP
admet-258	70	19	a	a	DET
admet-258	70	20	gall	gall	NOUN
admet-258	70	21	bladder	bladder	NOUN
admet-258	70	22	and	and	CCONJ
admet-258	70	23	most	most	ADV
admet-258	70	24	typical	typical	ADJ
admet-258	70	25	housing	housing	NOUN
admet-258	70	26	conditions	condition	NOUN
admet-258	70	27	with	with	ADP
admet-258	70	28	constant	constant	ADJ
admet-258	70	29	access	access	NOUN
admet-258	70	30	to	to	ADP
admet-258	70	31	food	food	NOUN
admet-258	70	32	,	,	PUNCT
admet-258	70	33	a	a	DET
admet-258	70	34	homostatic	homostatic	ADJ
admet-258	70	35	condition	condition	NOUN
admet-258	70	36	was	be	AUX
admet-258	70	37	assumed	assume	VERB
admet-258	70	38	for	for	ADP
admet-258	70	39	rats	rat	NOUN
admet-258	70	40	.	.	PUNCT
admet-258	71	1	in	in	ADP
admet-258	71	2	consequence	consequence	NOUN
admet-258	71	3	,	,	PUNCT
admet-258	71	4	fasted	fast	VERB
admet-258	71	5	and	and	CCONJ
admet-258	71	6	fed	fed	PROPN
admet-258	71	7	states	state	NOUN
admet-258	71	8	were	be	AUX
admet-258	71	9	not	not	PART
admet-258	71	10	distinguished	distinguish	VERB
admet-258	71	11	for	for	ADP
admet-258	71	12	the	the	DET
admet-258	71	13	rat	rat	NOUN
admet-258	71	14	medium	medium	NOUN
admet-258	71	15	.	.	PUNCT
admet-258	72	1	rat	rat	NOUN
admet-258	72	2	intestinal	intestinal	ADJ
admet-258	72	3	ph	ph	NOUN
admet-258	72	4	was	be	AUX
admet-258	72	5	averaged	average	VERB
admet-258	72	6	to	to	ADP
admet-258	72	7	6.0	6.0	NUM
admet-258	72	8	based	base	VERB
admet-258	72	9	on	on	ADP
admet-258	72	10	values	value	NOUN
admet-258	72	11	reported	report	VERB
admet-258	72	12	elsewhere	elsewhere	ADV
admet-258	72	13	[	[	X
admet-258	72	14	2,16,17	2,16,17	NUM
admet-258	72	15	]	]	PUNCT
admet-258	72	16	.	.	PUNCT
admet-258	73	1	an	an	DET
admet-258	73	2	average	average	NOUN
admet-258	73	3	was	be	AUX
admet-258	73	4	selected	select	VERB
admet-258	73	5	to	to	PART
admet-258	73	6	reflect	reflect	VERB
admet-258	73	7	the	the	DET
admet-258	73	8	main	main	ADJ
admet-258	73	9	areas	area	NOUN
admet-258	73	10	of	of	ADP
admet-258	73	11	absorption	absorption	NOUN
admet-258	73	12	within	within	ADP
admet-258	73	13	the	the	DET
admet-258	73	14	proximal	proximal	ADJ
admet-258	73	15	intestine	intestine	NOUN
admet-258	73	16	with	with	ADP
admet-258	73	17	reported	report	VERB
admet-258	73	18	ph	ph	ADJ
admet-258	73	19	values	value	NOUN
admet-258	73	20	between	between	ADP
admet-258	73	21	5.0	5.0	NUM
admet-258	73	22	and	and	CCONJ
admet-258	73	23	7.1	7.1	NUM
admet-258	73	24	.	.	PUNCT
admet-258	74	1	to	to	PART
admet-258	74	2	allow	allow	VERB
admet-258	74	3	higher	high	ADJ
admet-258	74	4	throughput	throughput	NOUN
admet-258	74	5	,	,	PUNCT
admet-258	74	6	use	use	NOUN
admet-258	74	7	of	of	ADP
admet-258	74	8	multiple	multiple	ADJ
admet-258	74	9	ph	ph	ADJ
admet-258	74	10	media	medium	NOUN
admet-258	74	11	was	be	AUX
admet-258	74	12	neglected	neglect	VERB
admet-258	74	13	.	.	PUNCT
admet-258	75	1	adjustment	adjustment	NOUN
admet-258	75	2	of	of	ADP
admet-258	75	3	surface	surface	NOUN
admet-258	75	4	tension	tension	NOUN
admet-258	75	5	had	have	VERB
admet-258	75	6	to	to	PART
admet-258	75	7	be	be	AUX
admet-258	75	8	balanced	balance	VERB
admet-258	75	9	with	with	ADP
admet-258	75	10	bile	bile	NOUN
admet-258	75	11	salt	salt	NOUN
admet-258	75	12	and	and	CCONJ
admet-258	75	13	phospholipid	phospholipid	NOUN
admet-258	75	14	concentrations	concentration	NOUN
admet-258	75	15	.	.	PUNCT
admet-258	76	1	addition	addition	NOUN
admet-258	76	2	of	of	ADP
admet-258	76	3	cholic	cholic	ADJ
admet-258	76	4	acid	acid	NOUN
admet-258	76	5	and	and	CCONJ
admet-258	76	6	chenodeoxycholic	chenodeoxycholic	ADJ
admet-258	76	7	acid	acid	NOUN
admet-258	76	8	sodium	sodium	NOUN
admet-258	76	9	was	be	AUX
admet-258	76	10	required	require	VERB
admet-258	76	11	to	to	PART
admet-258	76	12	achieve	achieve	VERB
admet-258	76	13	targeted	target	VERB
admet-258	76	14	surface	surface	NOUN
admet-258	76	15	tension	tension	NOUN
admet-258	76	16	values	value	NOUN
admet-258	76	17	.	.	PUNCT
admet-258	77	1	it	it	PRON
admet-258	77	2	was	be	AUX
admet-258	77	3	found	find	VERB
admet-258	77	4	that	that	SCONJ
admet-258	77	5	combination	combination	NOUN
admet-258	77	6	of	of	ADP
admet-258	77	7	bile	bile	NOUN
admet-258	77	8	salts	salt	NOUN
admet-258	77	9	provided	provide	VERB
admet-258	77	10	a	a	DET
admet-258	77	11	synergistic	synergistic	ADJ
admet-258	77	12	effect	effect	NOUN
admet-258	77	13	and	and	CCONJ
admet-258	77	14	provided	provide	VERB
admet-258	77	15	best	good	ADJ
admet-258	77	16	reduction	reduction	NOUN
admet-258	77	17	of	of	ADP
admet-258	77	18	surface	surface	NOUN
admet-258	77	19	tension	tension	NOUN
admet-258	77	20	.	.	PUNCT
admet-258	78	1	both	both	DET
admet-258	78	2	substances	substance	NOUN
admet-258	78	3	are	be	AUX
admet-258	78	4	reported	report	VERB
admet-258	78	5	to	to	PART
admet-258	78	6	be	be	AUX
admet-258	78	7	present	present	ADJ
admet-258	78	8	in	in	ADP
admet-258	78	9	rat	rat	NOUN
admet-258	78	10	bile	bile	NOUN
admet-258	78	11	fluids	fluid	NOUN
admet-258	78	12	and	and	CCONJ
admet-258	78	13	thus	thus	ADV
admet-258	78	14	have	have	VERB
admet-258	78	15	physiological	physiological	ADJ
admet-258	78	16	relevance	relevance	NOUN
admet-258	79	1	[	[	X
admet-258	79	2	18	18	NUM
admet-258	79	3	]	]	PUNCT
admet-258	79	4	.	.	PUNCT
admet-258	80	1	surface	surface	NOUN
admet-258	80	2	tension	tension	NOUN
admet-258	80	3	values	value	NOUN
admet-258	80	4	obtained	obtain	VERB
admet-258	80	5	for	for	ADP
admet-258	80	6	rsif	rsif	NOUN
admet-258	80	7	are	be	AUX
admet-258	80	8	in	in	ADP
admet-258	80	9	line	line	NOUN
admet-258	80	10	with	with	ADP
admet-258	80	11	recent	recent	ADJ
admet-258	80	12	data	datum	NOUN
admet-258	80	13	[	[	X
admet-258	80	14	19	19	NUM
admet-258	80	15	]	]	PUNCT
admet-258	80	16	.	.	PUNCT
admet-258	81	1	bile	bile	NOUN
admet-258	81	2	salt	salt	NOUN
admet-258	81	3	and	and	CCONJ
admet-258	81	4	phospholipid	phospholipid	NOUN
admet-258	81	5	concentrations	concentration	NOUN
admet-258	81	6	are	be	AUX
admet-258	81	7	slightly	slightly	ADV
admet-258	81	8	above	above	ADP
admet-258	81	9	values	value	NOUN
admet-258	81	10	referenced	reference	VERB
admet-258	81	11	and	and	CCONJ
admet-258	81	12	used	use	VERB
admet-258	81	13	for	for	ADP
admet-258	81	14	example	example	NOUN
admet-258	81	15	in	in	ADP
admet-258	81	16	gastroplus	gastroplus	ADJ
admet-258	81	17	models	model	NOUN
admet-258	81	18	and	and	CCONJ
admet-258	81	19	other	other	ADJ
admet-258	81	20	references	reference	NOUN
admet-258	81	21	[	[	X
admet-258	81	22	17	17	NUM
admet-258	81	23	]	]	PUNCT
admet-258	81	24	.	.	PUNCT
admet-258	82	1	the	the	DET
admet-258	82	2	values	value	NOUN
admet-258	82	3	for	for	ADP
admet-258	82	4	buffer	buffer	NOUN
admet-258	82	5	capacity	capacity	NOUN
admet-258	82	6	were	be	AUX
admet-258	82	7	estimated	estimate	VERB
admet-258	82	8	taking	take	VERB
admet-258	82	9	into	into	ADP
admet-258	82	10	account	account	NOUN
admet-258	82	11	human	human	ADJ
admet-258	82	12	fassif	fassif	NOUN
admet-258	82	13	-	-	PUNCT
admet-258	82	14	v2	v2	NOUN
admet-258	82	15	and	and	CCONJ
admet-258	82	16	the	the	DET
admet-258	82	17	constant	constant	ADJ
admet-258	82	18	bile	bile	NOUN
admet-258	82	19	flow	flow	NOUN
admet-258	82	20	,	,	PUNCT
admet-258	82	21	as	as	SCONJ
admet-258	82	22	there	there	PRON
admet-258	82	23	was	be	VERB
admet-258	82	24	no	no	DET
admet-258	82	25	reference	reference	NOUN
admet-258	82	26	available	available	ADJ
admet-258	82	27	at	at	ADP
admet-258	82	28	the	the	DET
admet-258	82	29	time	time	NOUN
admet-258	82	30	of	of	ADP
admet-258	82	31	rsif	rsif	NOUN
admet-258	82	32	development	development	NOUN
admet-258	82	33	.	.	PUNCT
admet-258	83	1	recent	recent	ADJ
admet-258	83	2	data	datum	NOUN
admet-258	83	3	from	from	ADP
admet-258	83	4	merchant	merchant	NOUN
admet-258	83	5	[	[	X
admet-258	83	6	19	19	NUM
admet-258	83	7	]	]	PUNCT
admet-258	83	8	indicate	indicate	VERB
admet-258	83	9	that	that	SCONJ
admet-258	83	10	this	this	DET
admet-258	83	11	value	value	NOUN
admet-258	83	12	appears	appear	VERB
admet-258	83	13	to	to	PART
admet-258	83	14	be	be	AUX
admet-258	83	15	too	too	ADV
admet-258	83	16	low	low	ADJ
admet-258	83	17	.	.	PUNCT
admet-258	84	1	depending	depend	VERB
admet-258	84	2	on	on	ADP
admet-258	84	3	new	new	ADJ
admet-258	84	4	insights	insight	NOUN
admet-258	84	5	rsif	rsif	NOUN
admet-258	84	6	may	may	AUX
admet-258	84	7	be	be	AUX
admet-258	84	8	further	far	ADV
admet-258	84	9	refined	refine	VERB
admet-258	84	10	with	with	ADP
admet-258	84	11	regard	regard	NOUN
admet-258	84	12	to	to	ADP
admet-258	84	13	bile	bile	NOUN
admet-258	84	14	salt	salt	NOUN
admet-258	84	15	concentration	concentration	NOUN
admet-258	84	16	,	,	PUNCT
admet-258	84	17	buffer	buffer	VERB
admet-258	84	18	capacity	capacity	NOUN
admet-258	84	19	and	and	CCONJ
admet-258	84	20	osmolality	osmolality	NOUN
admet-258	84	21	.	.	PUNCT
admet-258	85	1	further	further	ADJ
admet-258	85	2	refinement	refinement	NOUN
admet-258	85	3	of	of	ADP
admet-258	85	4	media	medium	NOUN
admet-258	85	5	could	could	AUX
admet-258	85	6	also	also	ADV
admet-258	85	7	reflect	reflect	VERB
admet-258	85	8	more	more	ADJ
admet-258	85	9	section	section	NOUN
admet-258	85	10	specific	specific	ADJ
admet-258	85	11	ph	ph	ADJ
admet-258	85	12	and	and	CCONJ
admet-258	85	13	bile	bile	NOUN
admet-258	85	14	concentrations	concentration	NOUN
admet-258	85	15	in	in	ADP
admet-258	85	16	analogy	analogy	NOUN
admet-258	85	17	to	to	ADP
admet-258	85	18	human	human	ADJ
admet-258	85	19	media	medium	NOUN
admet-258	85	20	published	publish	VERB
admet-258	85	21	[	[	X
admet-258	85	22	14	14	NUM
admet-258	85	23	]	]	PUNCT
admet-258	85	24	.	.	PUNCT
admet-258	86	1	table	table	NOUN
admet-258	86	2	2	2	NUM
admet-258	86	3	.	.	PUNCT
admet-258	86	4	composition	composition	NOUN
admet-258	86	5	of	of	ADP
admet-258	86	6	rsif	rsif	NOUN
admet-258	86	7	;	;	PUNCT
admet-258	86	8	100	100	NUM
admet-258	86	9	ml	ml	NOUN
admet-258	86	10	target	target	NOUN
admet-258	86	11	volume	volume	NOUN
admet-258	86	12	conc	conc	NOUN
admet-258	86	13	.	.	PUNCT
admet-258	87	1	(	(	PUNCT
admet-258	87	2	mm	mm	X
admet-258	87	3	)	)	PUNCT
admet-258	87	4	molecular	molecular	ADJ
admet-258	87	5	weight	weight	NOUN
admet-258	87	6	(	(	PUNCT
admet-258	87	7	g	g	NOUN
admet-258	87	8	/	/	SYM
admet-258	87	9	mol	mol	NOUN
admet-258	87	10	)	)	PUNCT
admet-258	87	11	weighted	weight	VERB
admet-258	87	12	sample	sample	NOUN
admet-258	87	13	(	(	PUNCT
admet-258	87	14	mg	mg	NOUN
admet-258	87	15	)	)	PUNCT
admet-258	87	16	sodium	sodium	NOUN
admet-258	87	17	taurocholate	taurocholate	NOUN
admet-258	87	18	5.00	5.00	NUM
admet-258	87	19	537.7	537.7	NUM
admet-258	87	20	269	269	NUM
admet-258	87	21	nacl	nacl	NOUN
admet-258	87	22	18.70	18.70	NUM
admet-258	87	23	58.0	58.0	NUM
admet-258	87	24	108	108	NUM
admet-258	87	25	lecithin	lecithin	NOUN
admet-258	87	26	5.16	5.16	NUM
admet-258	87	27	775.0	775.0	NUM
admet-258	87	28	400	400	NUM
admet-258	87	29	maleic	maleic	VERB
admet-258	87	30	acid	acid	NOUN
admet-258	87	31	29.86	29.86	NUM
admet-258	87	32	116.1	116.1	NUM
admet-258	87	33	347	347	NUM
admet-258	87	34	purified	purify	VERB
admet-258	87	35	water	water	PROPN
admet-258	87	36	q.s	q.s	PROPN
admet-258	87	37	.	.	PUNCT
admet-258	88	1	naoh	naoh	PROPN
admet-258	88	2	1	1	PROPN
admet-258	88	3	n	n	PROPN
admet-258	88	4	q.s	q.s	PROPN
admet-258	88	5	.	.	PROPN
admet-258	88	6	sodium	sodium	PROPN
admet-258	88	7	oleate	oleate	ADJ
admet-258	89	1	0.26	0.26	NUM
admet-258	89	2	304.4	304.4	NUM
admet-258	89	3	8	8	NUM
admet-258	89	4	sodium	sodium	NOUN
admet-258	89	5	cholate	cholate	NOUN
admet-258	89	6	hydrate	hydrate	NOUN
admet-258	89	7	12.50	12.50	NUM
admet-258	89	8	430.6	430.6	NUM
admet-258	89	9	538	538	NUM
admet-258	89	10	sodium	sodium	NOUN
admet-258	89	11	chenodeoxycholic	chenodeoxycholic	ADJ
admet-258	89	12	acid	acid	NOUN
admet-258	89	13	7.50	7.50	NUM
admet-258	89	14	414.6	414.6	NUM
admet-258	89	15	311	311	NUM
admet-258	89	16	glyceryl	glyceryl	NOUN
admet-258	89	17	monooleate	monooleate	VERB
admet-258	89	18	1.67	1.67	NUM
admet-258	89	19	356.5	356.5	NUM
admet-258	89	20	60	60	NUM
admet-258	89	21	admet	admet	PROPN
admet-258	89	22	&	&	CCONJ
admet-258	89	23	dmpk	dmpk	PROPN
admet-258	89	24	4(1	4(1	NOUN
admet-258	89	25	)	)	PUNCT
admet-258	89	26	(	(	PUNCT
admet-258	89	27	2016	2016	NUM
admet-258	89	28	)	)	PUNCT
admet-258	89	29	35	35	NUM
admet-258	89	30	-	-	SYM
admet-258	89	31	53	53	NUM
admet-258	89	32	simulated	simulate	VERB
admet-258	89	33	rat	rat	NOUN
admet-258	89	34	intestinal	intestinal	ADJ
admet-258	89	35	fluid	fluid	ADJ
admet-258	89	36	doi	doi	NOUN
admet-258	89	37	:	:	PUNCT
admet-258	89	38	10.5599	10.5599	NUM
admet-258	89	39	/	/	SYM
admet-258	89	40	admet.4.1.258	admet.4.1.258	NOUN
admet-258	89	41	39	39	NUM
admet-258	89	42	preparation	preparation	NOUN
admet-258	89	43	of	of	ADP
admet-258	89	44	rsif	rsif	NOUN
admet-258	89	45	in	in	ADP
admet-258	89	46	order	order	NOUN
admet-258	89	47	to	to	PART
admet-258	89	48	prepare	prepare	VERB
admet-258	89	49	100	100	NUM
admet-258	89	50	ml	ml	NOUN
admet-258	89	51	of	of	ADP
admet-258	89	52	rsif	rsif	NOUN
admet-258	89	53	,	,	PUNCT
admet-258	89	54	a	a	DET
admet-258	89	55	composition	composition	NOUN
admet-258	89	56	according	accord	VERB
admet-258	89	57	to	to	ADP
admet-258	89	58	table	table	NOUN
admet-258	89	59	2	2	NUM
admet-258	89	60	was	be	AUX
admet-258	89	61	used	use	VERB
admet-258	89	62	.	.	PUNCT
admet-258	90	1	sodium	sodium	NOUN
admet-258	90	2	taurocholate	taurocholate	NOUN
admet-258	90	3	,	,	PUNCT
admet-258	90	4	sodium	sodium	NOUN
admet-258	90	5	cholate	cholate	VERB
admet-258	90	6	hydrate	hydrate	NOUN
admet-258	90	7	,	,	PUNCT
admet-258	90	8	sodium	sodium	NOUN
admet-258	90	9	chenodeoxycholic	chenodeoxycholic	ADJ
admet-258	90	10	acid	acid	NOUN
admet-258	90	11	and	and	CCONJ
admet-258	90	12	nacl	nacl	NOUN
admet-258	90	13	were	be	AUX
admet-258	90	14	dissolved	dissolve	VERB
admet-258	90	15	in	in	ADP
admet-258	90	16	50	50	NUM
admet-258	90	17	ml	ml	NOUN
admet-258	90	18	of	of	ADP
admet-258	90	19	purified	purified	ADJ
admet-258	90	20	water	water	NOUN
admet-258	90	21	.	.	PUNCT
admet-258	91	1	after	after	ADP
admet-258	91	2	stirring	stir	VERB
admet-258	91	3	for	for	ADP
admet-258	91	4	30	30	NUM
admet-258	91	5	min	min	NOUN
admet-258	91	6	,	,	PUNCT
admet-258	91	7	lecithin	lecithin	NOUN
admet-258	91	8	,	,	PUNCT
admet-258	91	9	sodium	sodium	NOUN
admet-258	91	10	oleate	oleate	NOUN
admet-258	91	11	and	and	CCONJ
admet-258	91	12	glyceryl	glyceryl	NOUN
admet-258	91	13	monooleate	monooleate	NOUN
admet-258	91	14	were	be	AUX
admet-258	91	15	added	add	VERB
admet-258	91	16	.	.	PUNCT
admet-258	92	1	subsequently	subsequently	ADV
admet-258	92	2	,	,	PUNCT
admet-258	92	3	the	the	DET
admet-258	92	4	mixture	mixture	NOUN
admet-258	92	5	was	be	AUX
admet-258	92	6	sonicated	sonicate	VERB
admet-258	92	7	for	for	ADP
admet-258	92	8	about	about	ADV
admet-258	92	9	5	5	NUM
admet-258	92	10	-	-	SYM
admet-258	92	11	10	10	NUM
admet-258	92	12	min	min	NOUN
admet-258	92	13	and	and	CCONJ
admet-258	92	14	stirred	stir	VERB
admet-258	92	15	overnight	overnight	ADV
admet-258	92	16	.	.	PUNCT
admet-258	93	1	a	a	DET
admet-258	93	2	clear	clear	ADJ
admet-258	93	3	solution	solution	NOUN
admet-258	93	4	was	be	AUX
admet-258	93	5	obtained	obtain	VERB
admet-258	93	6	.	.	PUNCT
admet-258	94	1	maleic	maleic	VERB
admet-258	94	2	acid	acid	NOUN
admet-258	94	3	and	and	CCONJ
admet-258	94	4	40	40	NUM
admet-258	94	5	ml	ml	NOUN
admet-258	94	6	of	of	ADP
admet-258	94	7	purified	purified	ADJ
admet-258	94	8	water	water	NOUN
admet-258	94	9	were	be	AUX
admet-258	94	10	added	add	VERB
admet-258	94	11	,	,	PUNCT
admet-258	94	12	resulting	result	VERB
admet-258	94	13	in	in	ADP
admet-258	94	14	a	a	DET
admet-258	94	15	suspension	suspension	NOUN
admet-258	94	16	of	of	ADP
admet-258	94	17	ph	ph	NOUN
admet-258	94	18	around	around	ADP
admet-258	94	19	2.2	2.2	NUM
admet-258	94	20	.	.	PUNCT
admet-258	95	1	the	the	DET
admet-258	95	2	ph	ph	NOUN
admet-258	95	3	was	be	AUX
admet-258	95	4	adjusted	adjust	VERB
admet-258	95	5	to	to	ADP
admet-258	95	6	6.0	6.0	NUM
admet-258	95	7	by	by	ADP
admet-258	95	8	1	1	NUM
admet-258	95	9	m	m	NOUN
admet-258	95	10	naoh	naoh	NOUN
admet-258	95	11	.	.	PUNCT
admet-258	96	1	the	the	DET
admet-258	96	2	mixture	mixture	NOUN
admet-258	96	3	was	be	AUX
admet-258	96	4	stirred	stir	VERB
admet-258	96	5	until	until	SCONJ
admet-258	96	6	a	a	DET
admet-258	96	7	clear	clear	ADJ
admet-258	96	8	solution	solution	NOUN
admet-258	96	9	was	be	AUX
admet-258	96	10	obtained	obtain	VERB
admet-258	96	11	.	.	PUNCT
admet-258	97	1	if	if	SCONJ
admet-258	97	2	needed	need	VERB
admet-258	97	3	,	,	PUNCT
admet-258	97	4	the	the	DET
admet-258	97	5	ph	ph	NOUN
admet-258	97	6	was	be	AUX
admet-258	97	7	adjusted	adjust	VERB
admet-258	97	8	,	,	PUNCT
admet-258	97	9	again	again	ADV
admet-258	97	10	.	.	PUNCT
admet-258	98	1	finally	finally	ADV
admet-258	98	2	,	,	PUNCT
admet-258	98	3	the	the	DET
admet-258	98	4	volume	volume	NOUN
admet-258	98	5	was	be	AUX
admet-258	98	6	filled	fill	VERB
admet-258	98	7	up	up	ADP
admet-258	98	8	to	to	PART
admet-258	98	9	100	100	NUM
admet-258	98	10	ml	ml	NOUN
admet-258	98	11	by	by	ADP
admet-258	98	12	addition	addition	NOUN
admet-258	98	13	of	of	ADP
admet-258	98	14	purified	purified	ADJ
admet-258	98	15	water	water	NOUN
admet-258	98	16	.	.	PUNCT
admet-258	99	1	the	the	DET
admet-258	99	2	surface	surface	NOUN
admet-258	99	3	tension	tension	NOUN
admet-258	99	4	was	be	AUX
admet-258	99	5	determined	determine	VERB
admet-258	99	6	in	in	ADP
admet-258	99	7	triplicates	triplicate	NOUN
admet-258	99	8	using	use	VERB
admet-258	99	9	a	a	DET
admet-258	99	10	kibron	kibron	NOUN
admet-258	99	11	delta-8	delta-8	NUM
admet-258	99	12	tensiometer	tensiometer	NOUN
admet-258	99	13	(	(	PUNCT
admet-258	99	14	kibron	kibron	PROPN
admet-258	99	15	inc	inc	PROPN
admet-258	99	16	.	.	PROPN
admet-258	99	17	,	,	PUNCT
admet-258	99	18	helsinki	helsinki	PROPN
admet-258	99	19	)	)	PUNCT
admet-258	99	20	.	.	PUNCT
admet-258	100	1	an	an	DET
admet-258	100	2	average	average	ADJ
admet-258	100	3	value	value	NOUN
admet-258	100	4	of	of	ADP
admet-258	100	5	42.8	42.8	NUM
admet-258	100	6	mn	mn	NOUN
admet-258	100	7	/	/	SYM
admet-258	100	8	m	m	PROPN
admet-258	100	9	was	be	AUX
admet-258	100	10	obtained	obtain	VERB
admet-258	100	11	.	.	PUNCT
admet-258	101	1	pbpk	pbpk	PROPN
admet-258	101	2	simulations	simulation	VERB
admet-258	101	3	pbpk	pbpk	NOUN
admet-258	101	4	simulations	simulation	NOUN
admet-258	101	5	were	be	AUX
admet-258	101	6	performed	perform	VERB
admet-258	101	7	using	use	VERB
admet-258	101	8	the	the	DET
admet-258	101	9	acat	acat	ADJ
admet-258	101	10	model	model	NOUN
admet-258	101	11	of	of	ADP
admet-258	101	12	the	the	DET
admet-258	101	13	gastroplus	gastroplus	ADJ
admet-258	101	14	software	software	NOUN
admet-258	101	15	(	(	PUNCT
admet-258	101	16	simulations	simulation	NOUN
admet-258	101	17	plus	plus	CCONJ
admet-258	101	18	inc	inc	PROPN
admet-258	101	19	.	.	PROPN
admet-258	101	20	,	,	PUNCT
admet-258	101	21	lancaster	lancaster	PROPN
admet-258	101	22	)	)	PUNCT
admet-258	101	23	version	version	NOUN
admet-258	101	24	8.6	8.6	NUM
admet-258	101	25	.	.	PUNCT
admet-258	102	1	the	the	DET
admet-258	102	2	distribution	distribution	NOUN
admet-258	102	3	and	and	CCONJ
admet-258	102	4	elimination	elimination	NOUN
admet-258	102	5	were	be	AUX
admet-258	102	6	described	describe	VERB
admet-258	102	7	by	by	ADP
admet-258	102	8	a	a	DET
admet-258	102	9	compartmental	compartmental	ADJ
admet-258	102	10	pk	pk	NOUN
admet-258	102	11	model	model	NOUN
admet-258	102	12	.	.	PUNCT
admet-258	103	1	the	the	DET
admet-258	103	2	number	number	NOUN
admet-258	103	3	of	of	ADP
admet-258	103	4	compartments	compartment	NOUN
admet-258	103	5	and	and	CCONJ
admet-258	103	6	parameters	parameter	NOUN
admet-258	103	7	of	of	ADP
admet-258	103	8	the	the	DET
admet-258	103	9	model	model	NOUN
admet-258	103	10	were	be	AUX
admet-258	103	11	obtained	obtain	VERB
admet-258	103	12	by	by	ADP
admet-258	103	13	fitting	fit	VERB
admet-258	103	14	the	the	PRON
admet-258	103	15	in	in	ADP
admet-258	103	16	vivo	vivo	ADJ
admet-258	103	17	i.v	i.v	PROPN
admet-258	103	18	.	.	PUNCT
admet-258	104	1	time	time	NOUN
admet-258	104	2	-	-	PUNCT
admet-258	104	3	concentration	concentration	NOUN
admet-258	104	4	profiles	profile	NOUN
admet-258	104	5	in	in	ADP
admet-258	104	6	the	the	DET
admet-258	104	7	pkplus	pkplus	ADJ
admet-258	104	8	module	module	NOUN
admet-258	104	9	of	of	ADP
admet-258	104	10	gastroplus	gastroplus	NOUN
admet-258	104	11	.	.	PUNCT
admet-258	105	1	the	the	DET
admet-258	105	2	absorption	absorption	NOUN
admet-258	105	3	was	be	AUX
admet-258	105	4	predicted	predict	VERB
admet-258	105	5	by	by	ADP
admet-258	105	6	the	the	DET
admet-258	105	7	acat	acat	PROPN
admet-258	105	8	model	model	NOUN
admet-258	105	9	in	in	ADP
admet-258	105	10	gastroplus	gastroplus	NOUN
admet-258	105	11	using	use	VERB
admet-258	105	12	the	the	DET
admet-258	105	13	“	"	PUNCT
admet-258	105	14	rat	rat	NOUN
admet-258	105	15	physiological	physiological	NOUN
admet-258	105	16	fasted	fast	VERB
admet-258	105	17	”	"	PUNCT
admet-258	105	18	gi	gi	NOUN
admet-258	105	19	tract	tract	NOUN
admet-258	105	20	and	and	CCONJ
admet-258	105	21	based	base	VERB
admet-258	105	22	on	on	ADP
admet-258	105	23	the	the	DET
admet-258	105	24	physico	physico	NOUN
admet-258	105	25	-	-	PUNCT
admet-258	105	26	chemical	chemical	NOUN
admet-258	105	27	and	and	CCONJ
admet-258	105	28	in	in	ADP
admet-258	105	29	vitro	vitro	X
admet-258	105	30	adme	adme	NOUN
admet-258	105	31	properties	property	NOUN
admet-258	105	32	of	of	ADP
admet-258	105	33	the	the	DET
admet-258	105	34	compounds	compound	NOUN
admet-258	105	35	.	.	PUNCT
admet-258	106	1	the	the	DET
admet-258	106	2	permeability	permeability	NOUN
admet-258	106	3	of	of	ADP
admet-258	106	4	the	the	DET
admet-258	106	5	compound	compound	NOUN
admet-258	106	6	was	be	AUX
admet-258	106	7	characterized	characterize	VERB
admet-258	106	8	by	by	ADP
admet-258	106	9	measurement	measurement	NOUN
admet-258	106	10	in	in	ADP
admet-258	106	11	pampa	pampa	PROPN
admet-258	106	12	.	.	PUNCT
admet-258	107	1	first	first	ADV
admet-258	107	2	,	,	PUNCT
admet-258	107	3	a	a	DET
admet-258	107	4	calibration	calibration	NOUN
admet-258	107	5	of	of	ADP
admet-258	107	6	the	the	DET
admet-258	107	7	pampa	pampa	NOUN
admet-258	107	8	assay	assay	VERB
admet-258	107	9	to	to	ADP
admet-258	107	10	the	the	DET
admet-258	107	11	gastroplus	gastroplus	ADJ
admet-258	107	12	permeability	permeability	NOUN
admet-258	107	13	peff	peff	PROPN
admet-258	107	14	input	input	NOUN
admet-258	107	15	parameter	parameter	NOUN
admet-258	107	16	was	be	AUX
admet-258	107	17	carried	carry	VERB
admet-258	107	18	out	out	ADP
admet-258	107	19	.	.	PUNCT
admet-258	108	1	it	it	PRON
admet-258	108	2	was	be	AUX
admet-258	108	3	based	base	VERB
admet-258	108	4	on	on	ADP
admet-258	108	5	the	the	DET
admet-258	108	6	curve	curve	NOUN
admet-258	108	7	of	of	ADP
admet-258	108	8	pampa	pampa	PROPN
admet-258	108	9	versus	versus	ADP
admet-258	108	10	human	human	ADJ
admet-258	108	11	fraction	fraction	NOUN
admet-258	108	12	absorbed	absorb	VERB
admet-258	108	13	for	for	ADP
admet-258	108	14	83	83	NUM
admet-258	108	15	marketed	market	VERB
admet-258	108	16	compounds	compound	NOUN
admet-258	108	17	.	.	PUNCT
admet-258	109	1	the	the	DET
admet-258	109	2	curve	curve	NOUN
admet-258	109	3	of	of	ADP
admet-258	109	4	the	the	DET
admet-258	109	5	gastroplus	gastroplus	ADJ
admet-258	109	6	intrinsic	intrinsic	ADJ
admet-258	109	7	permeability	permeability	NOUN
admet-258	109	8	peff	peff	PROPN
admet-258	109	9	versus	versus	ADP
admet-258	109	10	human	human	ADJ
admet-258	109	11	fraction	fraction	NOUN
admet-258	109	12	absorbed	absorb	VERB
admet-258	109	13	was	be	AUX
admet-258	109	14	obtained	obtain	VERB
admet-258	109	15	by	by	ADP
admet-258	109	16	varying	vary	VERB
admet-258	109	17	the	the	DET
admet-258	109	18	peff	peff	NOUN
admet-258	109	19	value	value	NOUN
admet-258	109	20	,	,	PUNCT
admet-258	109	21	see	see	VERB
admet-258	109	22	figure	figure	NOUN
admet-258	109	23	1	1	NUM
admet-258	109	24	.	.	PUNCT
admet-258	110	1	the	the	DET
admet-258	110	2	correlation	correlation	NOUN
admet-258	110	3	between	between	ADP
admet-258	110	4	pampa	pampa	PROPN
admet-258	110	5	and	and	CCONJ
admet-258	110	6	peff	peff	PROPN
admet-258	110	7	was	be	AUX
admet-258	110	8	obtained	obtain	VERB
admet-258	110	9	by	by	ADP
admet-258	110	10	matching	match	VERB
admet-258	110	11	the	the	DET
admet-258	110	12	two	two	NUM
admet-258	110	13	curves	curve	NOUN
admet-258	110	14	.	.	PUNCT
admet-258	111	1	to	to	PART
admet-258	111	2	be	be	AUX
admet-258	111	3	consistent	consistent	ADJ
admet-258	111	4	with	with	ADP
admet-258	111	5	other	other	ADJ
admet-258	111	6	data	datum	NOUN
admet-258	111	7	of	of	ADP
admet-258	111	8	internal	internal	ADJ
admet-258	111	9	databases	database	NOUN
admet-258	111	10	an	an	DET
admet-258	111	11	animal	animal	NOUN
admet-258	111	12	weight	weight	NOUN
admet-258	111	13	of	of	ADP
admet-258	111	14	250	250	NUM
admet-258	111	15	g	g	NOUN
admet-258	111	16	was	be	AUX
admet-258	111	17	used	use	VERB
admet-258	111	18	.	.	PUNCT
admet-258	112	1	this	this	PRON
admet-258	112	2	is	be	AUX
admet-258	112	3	slightly	slightly	ADV
admet-258	112	4	below	below	ADP
admet-258	112	5	the	the	DET
admet-258	112	6	actual	actual	ADJ
admet-258	112	7	weight	weight	NOUN
admet-258	112	8	of	of	ADP
admet-258	112	9	animals	animal	NOUN
admet-258	112	10	in	in	ADP
admet-258	112	11	the	the	DET
admet-258	112	12	current	current	ADJ
admet-258	112	13	study	study	NOUN
admet-258	112	14	.	.	PUNCT
admet-258	113	1	the	the	DET
admet-258	113	2	difference	difference	NOUN
admet-258	113	3	in	in	ADP
admet-258	113	4	simulation	simulation	NOUN
admet-258	113	5	outcome	outcome	NOUN
admet-258	113	6	has	have	AUX
admet-258	113	7	been	be	AUX
admet-258	113	8	tested	test	VERB
admet-258	113	9	for	for	ADP
admet-258	113	10	selected	select	VERB
admet-258	113	11	cases	case	NOUN
admet-258	113	12	(	(	PUNCT
admet-258	113	13	data	datum	NOUN
admet-258	113	14	not	not	PART
admet-258	113	15	shown	show	VERB
admet-258	113	16	)	)	PUNCT
admet-258	113	17	and	and	CCONJ
admet-258	113	18	is	be	AUX
admet-258	113	19	rather	rather	ADV
admet-258	113	20	small	small	ADJ
admet-258	113	21	.	.	PUNCT
admet-258	114	1	no	no	DET
admet-258	114	2	effect	effect	NOUN
admet-258	114	3	on	on	ADP
admet-258	114	4	the	the	DET
admet-258	114	5	ranking	ranking	NOUN
admet-258	114	6	of	of	ADP
admet-258	114	7	the	the	DET
admet-258	114	8	simulation	simulation	NOUN
admet-258	114	9	results	result	NOUN
admet-258	114	10	has	have	AUX
admet-258	114	11	been	be	AUX
admet-258	114	12	observed	observe	VERB
admet-258	114	13	.	.	PUNCT
admet-258	115	1	the	the	DET
admet-258	115	2	animals	animal	NOUN
admet-258	115	3	had	have	VERB
admet-258	115	4	free	free	ADJ
admet-258	115	5	access	access	NOUN
admet-258	115	6	to	to	ADP
admet-258	115	7	food	food	NOUN
admet-258	115	8	,	,	PUNCT
admet-258	115	9	thus	thus	ADV
admet-258	115	10	the	the	DET
admet-258	115	11	feeding	feed	VERB
admet-258	115	12	state	state	NOUN
admet-258	115	13	was	be	AUX
admet-258	115	14	uncontrolled	uncontrolle	VERB
admet-258	115	15	,	,	PUNCT
admet-258	115	16	neither	neither	CCONJ
admet-258	115	17	fasted	fast	VERB
admet-258	115	18	nor	nor	CCONJ
admet-258	115	19	fed	feed	VERB
admet-258	115	20	.	.	PUNCT
admet-258	116	1	due	due	ADP
admet-258	116	2	to	to	ADP
admet-258	116	3	the	the	DET
admet-258	116	4	lack	lack	NOUN
admet-258	116	5	of	of	ADP
admet-258	116	6	the	the	DET
admet-258	116	7	gall	gall	NOUN
admet-258	116	8	bladder	bladder	NOUN
admet-258	116	9	,	,	PUNCT
admet-258	116	10	the	the	DET
admet-258	116	11	difference	difference	NOUN
admet-258	116	12	between	between	ADP
admet-258	116	13	fasted	fast	VERB
admet-258	116	14	and	and	CCONJ
admet-258	116	15	fed	feed	VERB
admet-258	116	16	state	state	NOUN
admet-258	116	17	for	for	ADP
admet-258	116	18	rats	rat	NOUN
admet-258	116	19	is	be	AUX
admet-258	116	20	regarded	regard	VERB
admet-258	116	21	as	as	SCONJ
admet-258	116	22	to	to	PART
admet-258	116	23	be	be	AUX
admet-258	116	24	small	small	ADJ
admet-258	116	25	.	.	PUNCT
admet-258	117	1	as	as	SCONJ
admet-258	117	2	tested	test	VERB
admet-258	117	3	(	(	PUNCT
admet-258	117	4	data	datum	NOUN
admet-258	117	5	not	not	PART
admet-258	117	6	shown	show	VERB
admet-258	117	7	)	)	PUNCT
admet-258	117	8	,	,	PUNCT
admet-258	117	9	the	the	DET
admet-258	117	10	impact	impact	NOUN
admet-258	117	11	of	of	ADP
admet-258	117	12	physiology	physiology	NOUN
admet-258	117	13	of	of	ADP
admet-258	117	14	the	the	DET
admet-258	117	15	simulation	simulation	NOUN
admet-258	117	16	model	model	NOUN
admet-258	117	17	is	be	AUX
admet-258	117	18	marginal	marginal	ADJ
admet-258	117	19	in	in	ADP
admet-258	117	20	comparison	comparison	NOUN
admet-258	117	21	to	to	ADP
admet-258	117	22	the	the	DET
admet-258	117	23	solubility	solubility	NOUN
admet-258	117	24	impact	impact	NOUN
admet-258	117	25	.	.	PUNCT
admet-258	118	1	thus	thus	ADV
admet-258	118	2	,	,	PUNCT
admet-258	118	3	the	the	DET
admet-258	118	4	fasted	fast	VERB
admet-258	118	5	rat	rat	NOUN
admet-258	118	6	physiology	physiology	NOUN
admet-258	118	7	was	be	AUX
admet-258	118	8	used	use	VERB
admet-258	118	9	.	.	PUNCT
admet-258	119	1	the	the	DET
admet-258	119	2	absorption	absorption	NOUN
admet-258	119	3	scaling	scale	VERB
admet-258	119	4	factor	factor	NOUN
admet-258	119	5	model	model	NOUN
admet-258	119	6	,	,	PUNCT
admet-258	119	7	designed	design	VERB
admet-258	119	8	to	to	PART
admet-258	119	9	take	take	VERB
admet-258	119	10	into	into	ADP
admet-258	119	11	account	account	NOUN
admet-258	119	12	the	the	DET
admet-258	119	13	regional	regional	ADJ
admet-258	119	14	changes	change	NOUN
admet-258	119	15	in	in	ADP
admet-258	119	16	permeability	permeability	NOUN
admet-258	119	17	,	,	PUNCT
admet-258	119	18	was	be	AUX
admet-258	119	19	the	the	DET
admet-258	119	20	“	"	PUNCT
admet-258	119	21	opt	opt	ADJ
admet-258	119	22	logd	logd	NOUN
admet-258	119	23	model	model	NOUN
admet-258	119	24	sa	sa	PROPN
admet-258	119	25	/	/	SYM
admet-258	119	26	v	v	NOUN
admet-258	119	27	6.1	6.1	NUM
admet-258	119	28	”	"	PUNCT
admet-258	119	29	.	.	PUNCT
admet-258	120	1	the	the	DET
admet-258	120	2	scaling	scaling	ADJ
admet-258	120	3	coefficient	coefficient	NOUN
admet-258	120	4	c4	c4	NOUN
admet-258	120	5	in	in	ADP
admet-258	120	6	the	the	DET
admet-258	120	7	colon	colon	NOUN
admet-258	120	8	was	be	AUX
admet-258	120	9	set	set	VERB
admet-258	120	10	to	to	ADP
admet-258	120	11	zero	zero	NUM
admet-258	120	12	in	in	ADP
admet-258	120	13	order	order	NOUN
admet-258	120	14	to	to	PART
admet-258	120	15	avoid	avoid	VERB
admet-258	120	16	overestimation	overestimation	NOUN
admet-258	120	17	of	of	ADP
admet-258	120	18	colonic	colonic	ADJ
admet-258	120	19	absorption	absorption	NOUN
admet-258	120	20	as	as	SCONJ
admet-258	120	21	outlined	outline	VERB
admet-258	120	22	in	in	ADP
admet-258	120	23	equation	equation	NOUN
admet-258	120	24	(	(	PUNCT
admet-258	120	25	1	1	NUM
admet-258	120	26	):	):	PUNCT
admet-258	120	27	c	c	PROPN
admet-258	120	28	dasf	dasf	PROPN
admet-258	120	29	c	c	PROPN
admet-258	120	30	4log3	4log3	NOUN
admet-258	120	31	10	10	NUM
admet-258	120	32			NUM
admet-258	121	1	(	(	PUNCT
admet-258	121	2	1	1	NUM
admet-258	121	3	)	)	PUNCT
admet-258	121	4	berghausen	berghausen	NOUN
admet-258	121	5	et	et	PROPN
admet-258	121	6	al	al	PROPN
admet-258	121	7	.	.	PROPN
admet-258	121	8	admet	admet	PROPN
admet-258	121	9	&	&	CCONJ
admet-258	121	10	dmpk	dmpk	PROPN
admet-258	121	11	4(1	4(1	NOUN
admet-258	121	12	)	)	PUNCT
admet-258	121	13	(	(	PUNCT
admet-258	121	14	2016	2016	NUM
admet-258	121	15	)	)	PUNCT
admet-258	121	16	35	35	NUM
admet-258	121	17	-	-	SYM
admet-258	121	18	53	53	NUM
admet-258	121	19	40	40	NUM
admet-258	121	20	figure	figure	NOUN
admet-258	121	21	1	1	NUM
admet-258	121	22	:	:	PUNCT
admet-258	121	23	peff	peff	PROPN
admet-258	121	24	conversion	conversion	NOUN
admet-258	121	25	based	base	VERB
admet-258	121	26	on	on	ADP
admet-258	121	27	log	log	PROPN
admet-258	121	28	pampa	pampa	NOUN
admet-258	121	29	measurements	measurement	NOUN
admet-258	121	30	as	as	ADP
admet-258	121	31	a	a	DET
admet-258	121	32	consequence	consequence	NOUN
admet-258	121	33	,	,	PUNCT
admet-258	121	34	the	the	DET
admet-258	121	35	original	original	ADJ
admet-258	121	36	model	model	NOUN
admet-258	121	37	led	lead	VERB
admet-258	121	38	to	to	ADP
admet-258	121	39	high	high	ADJ
admet-258	121	40	absorption	absorption	NOUN
admet-258	121	41	for	for	ADP
admet-258	121	42	all	all	DET
admet-258	121	43	lipophilic	lipophilic	ADJ
admet-258	121	44	drugs	drug	NOUN
admet-258	121	45	regardless	regardless	ADV
admet-258	121	46	of	of	ADP
admet-258	121	47	their	their	PRON
admet-258	121	48	pampa	pampa	NOUN
admet-258	121	49	(	(	PUNCT
admet-258	121	50	or	or	CCONJ
admet-258	121	51	caco-2	caco-2	NUM
admet-258	121	52	)	)	PUNCT
admet-258	121	53	permeability	permeability	NOUN
admet-258	121	54	,	,	PUNCT
admet-258	121	55	which	which	PRON
admet-258	121	56	did	do	AUX
admet-258	121	57	not	not	PART
admet-258	121	58	match	match	VERB
admet-258	121	59	our	our	PRON
admet-258	121	60	observations	observation	NOUN
admet-258	121	61	.	.	PUNCT
admet-258	122	1	the	the	DET
admet-258	122	2	property	property	NOUN
admet-258	122	3	space	space	NOUN
admet-258	122	4	of	of	ADP
admet-258	122	5	the	the	DET
admet-258	122	6	training	training	NOUN
admet-258	122	7	set	set	NOUN
admet-258	122	8	used	use	VERB
admet-258	122	9	in	in	ADP
admet-258	122	10	the	the	DET
admet-258	122	11	gastroplus	gastroplus	ADJ
admet-258	122	12	software	software	NOUN
admet-258	122	13	where	where	SCONJ
admet-258	122	14	poorly	poorly	ADV
admet-258	122	15	permeable	permeable	ADJ
admet-258	122	16	compounds	compound	NOUN
admet-258	122	17	are	be	AUX
admet-258	122	18	typically	typically	ADV
admet-258	122	19	hydrophilic	hydrophilic	ADJ
admet-258	122	20	molecules	molecule	NOUN
admet-258	122	21	does	do	AUX
admet-258	122	22	not	not	PART
admet-258	122	23	match	match	VERB
admet-258	122	24	the	the	DET
admet-258	122	25	property	property	NOUN
admet-258	122	26	space	space	NOUN
admet-258	122	27	of	of	ADP
admet-258	122	28	our	our	PRON
admet-258	122	29	discovery	discovery	NOUN
admet-258	122	30	molecules	molecule	NOUN
admet-258	122	31	that	that	PRON
admet-258	122	32	are	be	AUX
admet-258	122	33	characterized	characterize	VERB
admet-258	122	34	by	by	ADP
admet-258	122	35	a	a	DET
admet-258	122	36	higher	high	ADJ
admet-258	122	37	average	average	ADJ
admet-258	122	38	molecular	molecular	ADJ
admet-258	122	39	weight	weight	NOUN
admet-258	122	40	and	and	CCONJ
admet-258	122	41	for	for	ADP
admet-258	122	42	which	which	PRON
admet-258	122	43	poor	poor	ADJ
admet-258	122	44	permeability	permeability	NOUN
admet-258	122	45	is	be	AUX
admet-258	122	46	not	not	PART
admet-258	122	47	exclusively	exclusively	ADV
admet-258	122	48	driven	drive	VERB
admet-258	122	49	by	by	ADP
admet-258	122	50	low	low	ADJ
admet-258	122	51	lipophilicity	lipophilicity	NOUN
admet-258	122	52	.	.	PUNCT
admet-258	123	1	the	the	DET
admet-258	123	2	liver	liver	NOUN
admet-258	123	3	first	first	ADJ
admet-258	123	4	-	-	PUNCT
admet-258	123	5	pass	pass	NOUN
admet-258	123	6	extraction	extraction	NOUN
admet-258	123	7	was	be	AUX
admet-258	123	8	estimated	estimate	VERB
admet-258	123	9	with	with	ADP
admet-258	123	10	the	the	DET
admet-258	123	11	well	well	ADV
admet-258	123	12	-	-	PUNCT
admet-258	123	13	stirred	stir	VERB
admet-258	123	14	model	model	NOUN
admet-258	123	15	based	base	VERB
admet-258	123	16	on	on	ADP
admet-258	123	17	in	in	ADP
admet-258	123	18	vitro	vitro	X
admet-258	123	19	microsomal	microsomal	ADJ
admet-258	123	20	clearance	clearance	NOUN
admet-258	123	21	without	without	ADP
admet-258	123	22	taking	take	VERB
admet-258	123	23	into	into	ADP
admet-258	123	24	account	account	NOUN
admet-258	123	25	plasma	plasma	NOUN
admet-258	123	26	protein	protein	NOUN
admet-258	123	27	binding	bind	VERB
admet-258	123	28	or	or	CCONJ
admet-258	123	29	microsomal	microsomal	ADJ
admet-258	123	30	binding	binding	NOUN
admet-258	123	31	.	.	PUNCT
admet-258	124	1	this	this	DET
admet-258	124	2	approach	approach	NOUN
admet-258	124	3	was	be	AUX
admet-258	124	4	found	find	VERB
admet-258	124	5	to	to	PART
admet-258	124	6	be	be	AUX
admet-258	124	7	reasonable	reasonable	ADJ
admet-258	124	8	by	by	ADP
admet-258	124	9	parrot	parrot	NOUN
admet-258	124	10	et	et	NOUN
admet-258	124	11	al	al	PROPN
admet-258	125	1	[	[	X
admet-258	125	2	12	12	NUM
admet-258	125	3	]	]	PUNCT
admet-258	125	4	,	,	PUNCT
admet-258	125	5	germani	germani	PROPN
admet-258	125	6	et	et	PROPN
admet-258	125	7	al	al	PROPN
admet-258	126	1	[	[	X
admet-258	126	2	21	21	NUM
admet-258	126	3	]	]	PUNCT
admet-258	126	4	and	and	CCONJ
admet-258	126	5	jones	jones	PROPN
admet-258	126	6	et	et	PROPN
admet-258	126	7	al	al	PROPN
admet-258	127	1	[	[	X
admet-258	127	2	22	22	NUM
admet-258	127	3	]	]	PUNCT
admet-258	127	4	.	.	PUNCT
admet-258	128	1	it	it	PRON
admet-258	128	2	was	be	AUX
admet-258	128	3	compared	compare	VERB
admet-258	128	4	with	with	ADP
admet-258	128	5	the	the	DET
admet-258	128	6	estimation	estimation	NOUN
admet-258	128	7	based	base	VERB
admet-258	128	8	on	on	ADP
admet-258	128	9	the	the	DET
admet-258	128	10	in	in	ADP
admet-258	128	11	vivo	vivo	ADJ
admet-258	128	12	clearance	clearance	NOUN
admet-258	128	13	and	and	CCONJ
admet-258	128	14	provided	provide	VERB
admet-258	128	15	better	well	ADJ
admet-258	128	16	predictions	prediction	NOUN
admet-258	128	17	(	(	PUNCT
admet-258	128	18	see	see	VERB
admet-258	128	19	figure	figure	NOUN
admet-258	128	20	2	2	NUM
admet-258	128	21	)	)	PUNCT
admet-258	128	22	.	.	PUNCT
admet-258	129	1	admet	admet	PROPN
admet-258	129	2	&	&	CCONJ
admet-258	129	3	dmpk	dmpk	PROPN
admet-258	129	4	4(1	4(1	NOUN
admet-258	129	5	)	)	PUNCT
admet-258	129	6	(	(	PUNCT
admet-258	129	7	2016	2016	NUM
admet-258	129	8	)	)	PUNCT
admet-258	129	9	35	35	NUM
admet-258	129	10	-	-	SYM
admet-258	129	11	53	53	NUM
admet-258	129	12	simulated	simulate	VERB
admet-258	129	13	rat	rat	NOUN
admet-258	129	14	intestinal	intestinal	ADJ
admet-258	129	15	fluid	fluid	ADJ
admet-258	129	16	doi	doi	NOUN
admet-258	129	17	:	:	PUNCT
admet-258	129	18	10.5599	10.5599	NUM
admet-258	129	19	/	/	SYM
admet-258	129	20	admet.4.1.258	admet.4.1.258	PROPN
admet-258	129	21	41	41	NUM
admet-258	129	22	a	a	NOUN
admet-258	129	23	)	)	PUNCT
admet-258	129	24	liver	liver	NOUN
admet-258	129	25	first	first	ADJ
admet-258	129	26	pass	pass	NOUN
admet-258	129	27	based	base	VERB
admet-258	129	28	on	on	ADP
admet-258	129	29	in	in	ADP
admet-258	129	30	vivo	vivo	ADJ
admet-258	129	31	clearance	clearance	NOUN
admet-258	129	32	b	b	NOUN
admet-258	129	33	)	)	PUNCT
admet-258	129	34	liver	liver	NOUN
admet-258	129	35	first	first	ADJ
admet-258	129	36	pass	pass	NOUN
admet-258	129	37	based	base	VERB
admet-258	129	38	on	on	ADP
admet-258	129	39	microsomal	microsomal	ADJ
admet-258	129	40	clearance	clearance	NOUN
admet-258	129	41	figure	figure	NOUN
admet-258	129	42	2	2	NUM
admet-258	129	43	:	:	PUNCT
admet-258	129	44	comparison	comparison	NOUN
admet-258	129	45	of	of	ADP
admet-258	129	46	the	the	DET
admet-258	129	47	performance	performance	NOUN
admet-258	129	48	of	of	ADP
admet-258	129	49	the	the	DET
admet-258	129	50	model	model	NOUN
admet-258	129	51	between	between	ADP
admet-258	129	52	the	the	DET
admet-258	129	53	estimation	estimation	NOUN
admet-258	129	54	of	of	ADP
admet-258	129	55	the	the	DET
admet-258	129	56	liver	liver	NOUN
admet-258	129	57	first	first	ADV
admet-258	129	58	pass	pass	NOUN
admet-258	129	59	with	with	ADP
admet-258	129	60	the	the	DET
admet-258	129	61	in	in	ADP
admet-258	129	62	vivo	vivo	ADJ
admet-258	129	63	clearance	clearance	NOUN
admet-258	129	64	(	(	PUNCT
admet-258	129	65	a	a	NOUN
admet-258	129	66	)	)	PUNCT
admet-258	129	67	and	and	CCONJ
admet-258	129	68	microsomal	microsomal	ADJ
admet-258	129	69	clearance	clearance	NOUN
admet-258	129	70	(	(	PUNCT
admet-258	129	71	b	b	NOUN
admet-258	129	72	)	)	PUNCT
admet-258	129	73	for	for	ADP
admet-258	129	74	61	61	NUM
admet-258	129	75	proprietary	proprietary	ADJ
admet-258	129	76	compounds	compound	NOUN
admet-258	129	77	administered	administer	VERB
admet-258	129	78	to	to	ADP
admet-258	129	79	rats	rat	NOUN
admet-258	129	80	.	.	PUNCT
admet-258	130	1	the	the	DET
admet-258	130	2	octanol	octanol	NOUN
admet-258	130	3	-	-	PUNCT
admet-258	130	4	water	water	NOUN
admet-258	130	5	partition	partition	NOUN
admet-258	130	6	coefficient	coefficient	NOUN
admet-258	130	7	log	log	NOUN
admet-258	130	8	p	p	NOUN
admet-258	130	9	is	be	AUX
admet-258	130	10	based	base	VERB
admet-258	130	11	on	on	ADP
admet-258	130	12	measured	measured	ADJ
admet-258	130	13	values	value	NOUN
admet-258	130	14	.	.	PUNCT
admet-258	131	1	for	for	ADP
admet-258	131	2	all	all	DET
admet-258	131	3	suspensions	suspension	NOUN
admet-258	131	4	,	,	PUNCT
admet-258	131	5	a	a	DET
admet-258	131	6	particle	particle	NOUN
admet-258	131	7	radius	radius	NOUN
admet-258	131	8	of	of	ADP
admet-258	131	9	7	7	NUM
admet-258	131	10	m	m	PROPN
admet-258	131	11	was	be	AUX
admet-258	131	12	assumed	assume	VERB
admet-258	131	13	,	,	PUNCT
admet-258	131	14	which	which	PRON
admet-258	131	15	is	be	AUX
admet-258	131	16	a	a	DET
admet-258	131	17	typical	typical	ADJ
admet-258	131	18	number	number	NOUN
admet-258	131	19	based	base	VERB
admet-258	131	20	on	on	ADP
admet-258	131	21	our	our	PRON
admet-258	131	22	experience	experience	NOUN
admet-258	131	23	with	with	ADP
admet-258	131	24	compounds	compound	NOUN
admet-258	131	25	in	in	ADP
admet-258	131	26	the	the	DET
admet-258	131	27	lead	lead	ADJ
admet-258	131	28	optimization	optimization	NOUN
admet-258	131	29	phase	phase	NOUN
admet-258	131	30	.	.	PUNCT
admet-258	132	1	typically	typically	ADV
admet-258	132	2	,	,	PUNCT
admet-258	132	3	the	the	DET
admet-258	132	4	unknown	unknown	ADJ
admet-258	132	5	solid	solid	ADJ
admet-258	132	6	state	state	NOUN
admet-258	132	7	and	and	CCONJ
admet-258	132	8	the	the	DET
admet-258	132	9	impact	impact	NOUN
admet-258	132	10	of	of	ADP
admet-258	132	11	the	the	DET
admet-258	132	12	amorphous	amorphous	ADJ
admet-258	132	13	form	form	NOUN
admet-258	132	14	are	be	AUX
admet-258	132	15	supposed	suppose	VERB
admet-258	132	16	to	to	PART
admet-258	132	17	play	play	VERB
admet-258	132	18	a	a	DET
admet-258	132	19	major	major	ADJ
admet-258	132	20	role	role	NOUN
admet-258	132	21	for	for	ADP
admet-258	132	22	particle	particle	NOUN
admet-258	132	23	dissolution	dissolution	NOUN
admet-258	132	24	,	,	PUNCT
admet-258	132	25	which	which	PRON
admet-258	132	26	may	may	AUX
admet-258	132	27	overrule	overrule	VERB
admet-258	132	28	the	the	DET
admet-258	132	29	particle	particle	NOUN
admet-258	132	30	size	size	NOUN
admet-258	132	31	effect	effect	NOUN
admet-258	132	32	.	.	PUNCT
admet-258	133	1	information	information	NOUN
admet-258	133	2	about	about	ADP
admet-258	133	3	dose	dose	NOUN
admet-258	133	4	dependence	dependence	NOUN
admet-258	133	5	of	of	ADP
admet-258	133	6	systemic	systemic	ADJ
admet-258	133	7	clearance	clearance	NOUN
admet-258	133	8	is	be	AUX
admet-258	133	9	typically	typically	ADV
admet-258	133	10	not	not	PART
admet-258	133	11	available	available	ADJ
admet-258	133	12	in	in	ADP
admet-258	133	13	the	the	DET
admet-258	133	14	lead	lead	ADJ
admet-258	133	15	optimization	optimization	NOUN
admet-258	133	16	stage	stage	NOUN
admet-258	133	17	and	and	CCONJ
admet-258	133	18	the	the	DET
admet-258	133	19	assumption	assumption	NOUN
admet-258	133	20	made	make	VERB
admet-258	133	21	in	in	ADP
admet-258	133	22	this	this	DET
admet-258	133	23	study	study	NOUN
admet-258	133	24	is	be	AUX
admet-258	133	25	that	that	SCONJ
admet-258	133	26	clearance	clearance	NOUN
admet-258	133	27	does	do	AUX
admet-258	133	28	not	not	PART
admet-258	133	29	significantly	significantly	ADV
admet-258	133	30	change	change	VERB
admet-258	133	31	with	with	ADP
admet-258	133	32	the	the	DET
admet-258	133	33	dose	dose	NOUN
admet-258	133	34	.	.	PUNCT
admet-258	134	1	pharmacokinetic	pharmacokinetic	ADJ
admet-258	134	2	studies	study	NOUN
admet-258	134	3	pharmacokinetic	pharmacokinetic	ADJ
admet-258	134	4	studies	study	NOUN
admet-258	134	5	have	have	AUX
admet-258	134	6	been	be	AUX
admet-258	134	7	performed	perform	VERB
admet-258	134	8	in	in	ADP
admet-258	134	9	male	male	ADJ
admet-258	134	10	sprague	sprague	NOUN
admet-258	134	11	-	-	PUNCT
admet-258	134	12	dawley	dawley	NOUN
admet-258	134	13	rats	rat	NOUN
admet-258	134	14	,	,	PUNCT
admet-258	134	15	originating	originate	VERB
admet-258	134	16	from	from	ADP
admet-258	134	17	charles	charles	PROPN
admet-258	134	18	river	river	PROPN
admet-258	134	19	wiga	wiga	NOUN
admet-258	134	20	(	(	PUNCT
admet-258	134	21	germany	germany	PROPN
admet-258	134	22	)	)	PUNCT
admet-258	134	23	.	.	PUNCT
admet-258	135	1	the	the	DET
admet-258	135	2	experiment	experiment	NOUN
admet-258	135	3	was	be	AUX
admet-258	135	4	performed	perform	VERB
admet-258	135	5	according	accord	VERB
admet-258	135	6	to	to	ADP
admet-258	135	7	the	the	DET
admet-258	135	8	regulations	regulation	NOUN
admet-258	135	9	effective	effective	ADJ
admet-258	135	10	in	in	ADP
admet-258	135	11	the	the	DET
admet-258	135	12	canton	canton	PROPN
admet-258	135	13	basel	basel	PROPN
admet-258	135	14	-	-	PUNCT
admet-258	135	15	city	city	PROPN
admet-258	135	16	,	,	PUNCT
admet-258	135	17	switzerland	switzerland	PROPN
admet-258	135	18	.	.	PROPN
admet-258	136	1	six	six	NUM
admet-258	136	2	to	to	PART
admet-258	136	3	four	four	NUM
admet-258	136	4	days	day	NOUN
admet-258	136	5	before	before	ADP
admet-258	136	6	first	first	ADJ
admet-258	136	7	drug	drug	PROPN
admet-258	136	8	administration	administration	NOUN
admet-258	136	9	,	,	PUNCT
admet-258	136	10	the	the	DET
admet-258	136	11	rats	rat	NOUN
admet-258	136	12	(	(	PUNCT
admet-258	136	13	body	body	NOUN
admet-258	136	14	weight	weight	NOUN
admet-258	136	15	approx	approx	NOUN
admet-258	136	16	.	.	PUNCT
admet-258	137	1	270	270	NUM
admet-258	137	2	-	-	SYM
admet-258	137	3	330	330	NUM
admet-258	137	4	g	g	NOUN
admet-258	137	5	)	)	PUNCT
admet-258	137	6	were	be	AUX
admet-258	137	7	anesthetized	anesthetize	VERB
admet-258	137	8	and	and	CCONJ
admet-258	137	9	catheters	catheter	NOUN
admet-258	137	10	were	be	AUX
admet-258	137	11	surgically	surgically	ADV
admet-258	137	12	implanted	implant	VERB
admet-258	137	13	into	into	ADP
admet-258	137	14	the	the	DET
admet-258	137	15	femoral	femoral	ADJ
admet-258	137	16	artery	artery	NOUN
admet-258	137	17	(	(	PUNCT
admet-258	137	18	for	for	ADP
admet-258	137	19	blood	blood	NOUN
admet-258	137	20	collection	collection	NOUN
admet-258	137	21	)	)	PUNCT
admet-258	137	22	and	and	CCONJ
admet-258	137	23	femoral	femoral	ADJ
admet-258	137	24	vein	vein	NOUN
admet-258	137	25	(	(	PUNCT
admet-258	137	26	for	for	ADP
admet-258	137	27	intravenous	intravenous	ADJ
admet-258	137	28	injection	injection	NOUN
admet-258	137	29	)	)	PUNCT
admet-258	137	30	.	.	PUNCT
admet-258	138	1	the	the	DET
admet-258	138	2	catheters	catheter	NOUN
admet-258	138	3	were	be	AUX
admet-258	138	4	exteriorized	exteriorize	VERB
admet-258	138	5	at	at	ADP
admet-258	138	6	the	the	DET
admet-258	138	7	neck	neck	NOUN
admet-258	138	8	where	where	SCONJ
admet-258	138	9	they	they	PRON
admet-258	138	10	were	be	AUX
admet-258	138	11	fixed	fix	VERB
admet-258	138	12	via	via	ADP
admet-258	138	13	the	the	DET
admet-258	138	14	tether	tether	NOUN
admet-258	138	15	and	and	CCONJ
admet-258	138	16	a	a	DET
admet-258	138	17	flexible	flexible	ADJ
admet-258	138	18	spring	spring	NOUN
admet-258	138	19	to	to	ADP
admet-258	138	20	a	a	DET
admet-258	138	21	harvard	harvard	NOUN
admet-258	138	22	swivel	swivel	NOUN
admet-258	138	23	system	system	NOUN
admet-258	138	24	,	,	PUNCT
admet-258	138	25	which	which	PRON
admet-258	138	26	allowed	allow	VERB
admet-258	138	27	blood	blood	NOUN
admet-258	138	28	sampling	sampling	NOUN
admet-258	138	29	and	and	CCONJ
admet-258	138	30	intravenous	intravenous	ADJ
admet-258	138	31	injections	injection	NOUN
admet-258	138	32	without	without	ADP
admet-258	138	33	disturbing	disturb	VERB
admet-258	138	34	the	the	DET
admet-258	138	35	freely	freely	ADV
admet-258	138	36	-	-	PUNCT
admet-258	138	37	moving	move	VERB
admet-258	138	38	animal	animal	NOUN
admet-258	138	39	.	.	PUNCT
admet-258	139	1	for	for	ADP
admet-258	139	2	analgesic	analgesic	ADJ
admet-258	139	3	treatment	treatment	NOUN
admet-258	139	4	,	,	PUNCT
admet-258	139	5	animals	animal	NOUN
admet-258	139	6	received	receive	VERB
admet-258	139	7	temgesic	temgesic	ADP
admet-258	139	8	(	(	PUNCT
admet-258	139	9	10	10	NUM
admet-258	139	10	µg	µg	ADV
admet-258	139	11	kg-1	kg-1	X
admet-258	139	12	s.c	s.c	PROPN
admet-258	139	13	.	.	PROPN
admet-258	139	14	)	)	PUNCT
admet-258	139	15	before	before	ADP
admet-258	139	16	surgery	surgery	NOUN
admet-258	139	17	and	and	CCONJ
admet-258	139	18	subsequently	subsequently	ADV
admet-258	139	19	twice	twice	ADV
admet-258	139	20	at	at	ADP
admet-258	139	21	appropriate	appropriate	ADJ
admet-258	139	22	times	time	NOUN
admet-258	139	23	after	after	ADP
admet-258	139	24	surgery	surgery	NOUN
admet-258	139	25	.	.	PUNCT
admet-258	140	1	animals	animal	NOUN
admet-258	140	2	were	be	AUX
admet-258	140	3	kept	keep	VERB
admet-258	140	4	individually	individually	ADV
admet-258	140	5	in	in	ADP
admet-258	140	6	macrolon	macrolon	NOUN
admet-258	140	7	cages	cage	NOUN
admet-258	140	8	,	,	PUNCT
admet-258	140	9	with	with	ADP
admet-258	140	10	free	free	ADJ
admet-258	140	11	access	access	NOUN
admet-258	140	12	to	to	ADP
admet-258	140	13	food	food	NOUN
admet-258	140	14	and	and	CCONJ
admet-258	140	15	water	water	NOUN
admet-258	140	16	throughout	throughout	ADP
admet-258	140	17	the	the	DET
admet-258	140	18	experiment	experiment	NOUN
admet-258	140	19	.	.	PUNCT
admet-258	141	1	dosing	dose	VERB
admet-258	141	2	i.v	i.v	PROPN
admet-258	141	3	.	.	PUNCT
admet-258	142	1	and	and	CCONJ
admet-258	142	2	p.o	p.o	PROPN
admet-258	142	3	.	.	PROPN
admet-258	142	4	was	be	AUX
admet-258	142	5	performed	perform	VERB
admet-258	142	6	in	in	ADP
admet-258	142	7	two	two	NUM
admet-258	142	8	different	different	ADJ
admet-258	142	9	animal	animal	NOUN
admet-258	142	10	groups	group	NOUN
admet-258	142	11	.	.	PUNCT
admet-258	143	1	for	for	ADP
admet-258	143	2	per	per	ADP
admet-258	143	3	oral	oral	ADJ
admet-258	143	4	administration	administration	NOUN
admet-258	143	5	,	,	PUNCT
admet-258	143	6	the	the	DET
admet-258	143	7	compounds	compound	NOUN
admet-258	143	8	were	be	AUX
admet-258	143	9	formulated	formulate	VERB
admet-258	143	10	as	as	ADP
admet-258	143	11	a	a	DET
admet-258	143	12	suspension	suspension	NOUN
admet-258	143	13	in	in	ADP
admet-258	143	14	methyl	methyl	NOUN
admet-258	143	15	cellulose	cellulose	NOUN
admet-258	143	16	.	.	PUNCT
admet-258	144	1	for	for	ADP
admet-258	144	2	intravenous	intravenous	ADJ
admet-258	144	3	administration	administration	NOUN
admet-258	144	4	,	,	PUNCT
admet-258	144	5	the	the	DET
admet-258	144	6	compounds	compound	NOUN
admet-258	144	7	were	be	AUX
admet-258	144	8	dissolved	dissolve	VERB
admet-258	144	9	in	in	ADP
admet-258	144	10	an	an	DET
admet-258	144	11	appropriate	appropriate	ADJ
admet-258	144	12	mixture	mixture	NOUN
admet-258	144	13	of	of	ADP
admet-258	144	14	n	n	CCONJ
admet-258	144	15	-	-	PUNCT
admet-258	144	16	methyl	methyl	NOUN
admet-258	144	17	pyrrolidone	pyrrolidone	NOUN
admet-258	144	18	(	(	PUNCT
admet-258	144	19	nmp	nmp	PROPN
admet-258	144	20	)	)	PUNCT
admet-258	144	21	and	and	CCONJ
admet-258	144	22	poly(ethylene	poly(ethylene	ADJ
admet-258	144	23	glycol	glycol	NOUN
admet-258	144	24	)	)	PUNCT
admet-258	144	25	200	200	NUM
admet-258	144	26	(	(	PUNCT
admet-258	144	27	peg	peg	NOUN
admet-258	144	28	)	)	PUNCT
admet-258	144	29	.	.	PUNCT
admet-258	145	1	for	for	ADP
admet-258	145	2	sample	sample	NOUN
admet-258	145	3	analysis	analysis	NOUN
admet-258	145	4	,	,	PUNCT
admet-258	145	5	approximately	approximately	ADV
admet-258	145	6	50	50	NUM
admet-258	145	7	µl	µl	NOUN
admet-258	145	8	of	of	ADP
admet-258	145	9	blood	blood	NOUN
admet-258	145	10	was	be	AUX
admet-258	145	11	taken	take	VERB
admet-258	145	12	.	.	PUNCT
admet-258	146	1	30	30	NUM
admet-258	146	2	µl	µl	NOUN
admet-258	146	3	of	of	ADP
admet-258	146	4	blood	blood	NOUN
admet-258	146	5	was	be	AUX
admet-258	146	6	mixed	mix	VERB
admet-258	146	7	with	with	ADP
admet-258	146	8	200	200	NUM
admet-258	146	9	µl	µl	NOUN
admet-258	146	10	of	of	ADP
admet-258	146	11	acetonitrile	acetonitrile	NOUN
admet-258	146	12	and	and	CCONJ
admet-258	146	13	centrifuged	centrifuge	VERB
admet-258	146	14	at	at	ADP
admet-258	146	15	4	4	NUM
admet-258	146	16	°	°	NOUN
admet-258	146	17	c	c	NOUN
admet-258	146	18	.	.	PUNCT
admet-258	147	1	approx	approx	PROPN
admet-258	147	2	.	.	PUNCT
admet-258	148	1	200	200	NUM
admet-258	148	2	µl	µl	NOUN
admet-258	148	3	of	of	ADP
admet-258	148	4	supernatant	supernatant	NOUN
admet-258	148	5	was	be	AUX
admet-258	148	6	transferred	transfer	VERB
admet-258	148	7	into	into	ADP
admet-258	148	8	a	a	DET
admet-258	148	9	microtiter	microtiter	ADJ
admet-258	148	10	plate	plate	NOUN
admet-258	148	11	and	and	CCONJ
admet-258	148	12	mixed	mix	VERB
admet-258	148	13	with	with	ADP
admet-258	148	14	200	200	NUM
admet-258	148	15	µl	µl	PART
admet-258	148	16	0.1	0.1	NUM
admet-258	148	17	%	%	NOUN
admet-258	148	18	formic	formic	ADJ
admet-258	148	19	acid	acid	NOUN
admet-258	148	20	.	.	PUNCT
admet-258	149	1	an	an	DET
admet-258	149	2	aliquot	aliquot	NOUN
admet-258	149	3	of	of	ADP
admet-258	149	4	each	each	DET
admet-258	149	5	sample	sample	NOUN
admet-258	149	6	was	be	AUX
admet-258	149	7	injected	inject	VERB
admet-258	149	8	into	into	ADP
admet-258	149	9	the	the	DET
admet-258	149	10	berghausen	berghausen	NOUN
admet-258	149	11	et	et	PROPN
admet-258	149	12	al	al	PROPN
admet-258	149	13	.	.	PROPN
admet-258	149	14	admet	admet	PROPN
admet-258	149	15	&	&	CCONJ
admet-258	149	16	dmpk	dmpk	PROPN
admet-258	149	17	4(1	4(1	NOUN
admet-258	149	18	)	)	PUNCT
admet-258	149	19	(	(	PUNCT
admet-258	149	20	2016	2016	NUM
admet-258	149	21	)	)	PUNCT
admet-258	149	22	35	35	NUM
admet-258	149	23	-	-	SYM
admet-258	149	24	53	53	NUM
admet-258	149	25	42	42	NUM
admet-258	149	26	lc	lc	PROPN
admet-258	149	27	-	-	PUNCT
admet-258	149	28	ms	ms	PROPN
admet-258	149	29	/	/	SYM
admet-258	149	30	ms	ms	NOUN
admet-258	149	31	system	system	NOUN
admet-258	149	32	for	for	ADP
admet-258	149	33	analysis	analysis	NOUN
admet-258	149	34	.	.	PUNCT
admet-258	150	1	gi	gi	NOUN
admet-258	150	2	dissolution	dissolution	PROPN
admet-258	150	3	assay	assay	PROPN
admet-258	150	4	full	full	ADJ
admet-258	150	5	gi	gi	NOUN
admet-258	150	6	dissolution	dissolution	NOUN
admet-258	150	7	was	be	AUX
admet-258	150	8	performed	perform	VERB
admet-258	150	9	by	by	ADP
admet-258	150	10	a	a	DET
admet-258	150	11	modified	modify	VERB
admet-258	150	12	setup	setup	NOUN
admet-258	150	13	based	base	VERB
admet-258	150	14	on	on	ADP
admet-258	150	15	the	the	DET
admet-258	150	16	proposal	proposal	NOUN
admet-258	150	17	of	of	ADP
admet-258	150	18	gao	gao	PROPN
admet-258	150	19	et	et	PROPN
admet-258	150	20	al	al	PROPN
admet-258	150	21	.	.	PUNCT
admet-258	151	1	[	[	X
admet-258	151	2	6	6	NUM
admet-258	151	3	]	]	PUNCT
admet-258	151	4	.	.	PUNCT
admet-258	152	1	their	their	PRON
admet-258	152	2	gi	gi	PROPN
admet-258	152	3	dissolution	dissolution	PROPN
admet-258	152	4	model	model	NOUN
admet-258	152	5	takes	take	VERB
admet-258	152	6	into	into	ADP
admet-258	152	7	consideration	consideration	NOUN
admet-258	152	8	the	the	DET
admet-258	152	9	transit	transit	NOUN
admet-258	152	10	times	time	NOUN
admet-258	152	11	in	in	ADP
admet-258	152	12	the	the	DET
admet-258	152	13	stomach	stomach	NOUN
admet-258	152	14	and	and	CCONJ
admet-258	152	15	four	four	NUM
admet-258	152	16	additional	additional	ADJ
admet-258	152	17	segments	segment	NOUN
admet-258	152	18	in	in	ADP
admet-258	152	19	the	the	DET
admet-258	152	20	intestine	intestine	NOUN
admet-258	152	21	.	.	PUNCT
admet-258	153	1	gao	gao	PROPN
admet-258	153	2	et	et	PROPN
admet-258	153	3	al	al	PROPN
admet-258	153	4	.	.	PROPN
admet-258	153	5	included	include	VERB
admet-258	153	6	the	the	DET
admet-258	153	7	dilution	dilution	NOUN
admet-258	153	8	that	that	PRON
admet-258	153	9	is	be	AUX
admet-258	153	10	supposed	suppose	VERB
admet-258	153	11	to	to	PART
admet-258	153	12	happen	happen	VERB
admet-258	153	13	during	during	ADP
admet-258	153	14	the	the	DET
admet-258	153	15	transit	transit	NOUN
admet-258	153	16	through	through	ADP
admet-258	153	17	the	the	DET
admet-258	153	18	gastrointestinal	gastrointestinal	ADJ
admet-258	153	19	tract	tract	NOUN
admet-258	153	20	.	.	PUNCT
admet-258	154	1	in	in	ADP
admet-258	154	2	particular	particular	ADJ
admet-258	154	3	,	,	PUNCT
admet-258	154	4	dilution	dilution	NOUN
admet-258	154	5	was	be	AUX
admet-258	154	6	based	base	VERB
admet-258	154	7	on	on	ADP
admet-258	154	8	basal	basal	ADJ
admet-258	154	9	acid	acid	NOUN
admet-258	154	10	output	output	NOUN
admet-258	154	11	,	,	PUNCT
admet-258	154	12	the	the	DET
admet-258	154	13	pancreatic	pancreatic	ADJ
admet-258	154	14	juice	juice	NOUN
admet-258	154	15	secretion	secretion	NOUN
admet-258	154	16	rate	rate	NOUN
admet-258	154	17	and	and	CCONJ
admet-258	154	18	the	the	DET
admet-258	154	19	bile	bile	NOUN
admet-258	154	20	flow	flow	NOUN
admet-258	154	21	.	.	PUNCT
admet-258	155	1	gao	gao	PROPN
admet-258	155	2	et	et	PROPN
admet-258	155	3	al	al	PROPN
admet-258	155	4	.	.	PROPN
admet-258	155	5	proposed	propose	VERB
admet-258	155	6	a	a	DET
admet-258	155	7	basal	basal	ADJ
admet-258	155	8	acid	acid	NOUN
admet-258	155	9	output	output	NOUN
admet-258	155	10	of	of	ADP
admet-258	155	11	0.8657	0.8657	NUM
admet-258	155	12	ml/4	ml/4	NOUN
admet-258	155	13	h/100	h/100	AUX
admet-258	155	14	g.	g.	PROPN
admet-258	155	15	in	in	ADP
admet-258	155	16	order	order	NOUN
admet-258	155	17	to	to	PART
admet-258	155	18	calculate	calculate	VERB
admet-258	155	19	the	the	DET
admet-258	155	20	dilution	dilution	NOUN
admet-258	155	21	in	in	ADP
admet-258	155	22	the	the	DET
admet-258	155	23	small	small	ADJ
admet-258	155	24	intestine	intestine	NOUN
admet-258	155	25	,	,	PUNCT
admet-258	155	26	a	a	DET
admet-258	155	27	pancreatic	pancreatic	ADJ
admet-258	155	28	juice	juice	NOUN
admet-258	155	29	secretion	secretion	NOUN
admet-258	155	30	rate	rate	NOUN
admet-258	155	31	of	of	ADP
admet-258	155	32	0.033	0.033	NUM
admet-258	155	33	ml	ml	NOUN
admet-258	155	34	/	/	SYM
admet-258	155	35	min	min	NOUN
admet-258	155	36	/	/	SYM
admet-258	155	37	kg	kg	PROPN
admet-258	155	38	is	be	AUX
admet-258	155	39	suggested	suggest	VERB
admet-258	155	40	;	;	PUNCT
admet-258	155	41	bile	bile	NOUN
admet-258	155	42	flow	flow	NOUN
admet-258	155	43	is	be	AUX
admet-258	155	44	set	set	VERB
admet-258	155	45	to	to	ADP
admet-258	155	46	70	70	NUM
admet-258	155	47	ml	ml	NOUN
admet-258	155	48	/	/	SYM
admet-258	155	49	day	day	NOUN
admet-258	155	50	/	/	SYM
admet-258	155	51	kg	kg	NOUN
admet-258	155	52	in	in	ADP
admet-258	155	53	their	their	PRON
admet-258	155	54	setup	setup	NOUN
admet-258	155	55	.	.	PUNCT
admet-258	156	1	the	the	DET
admet-258	156	2	corresponding	correspond	VERB
admet-258	156	3	transit	transit	NOUN
admet-258	156	4	times	time	NOUN
admet-258	156	5	are	be	AUX
admet-258	156	6	0.25	0.25	NUM
admet-258	156	7	h	h	NOUN
admet-258	156	8	in	in	ADP
admet-258	156	9	the	the	DET
admet-258	156	10	stomach	stomach	NOUN
admet-258	156	11	and	and	CCONJ
admet-258	156	12	0.2	0.2	NUM
admet-258	156	13	,	,	PUNCT
admet-258	156	14	2.0	2.0	NUM
admet-258	156	15	,	,	PUNCT
admet-258	156	16	4.5	4.5	NUM
admet-258	156	17	and	and	CCONJ
admet-258	156	18	8	8	NUM
admet-258	156	19	h	h	NOUN
admet-258	156	20	for	for	ADP
admet-258	156	21	duodenum	duodenum	ADJ
admet-258	156	22	,	,	PUNCT
admet-258	156	23	jejunum	jejunum	ADJ
admet-258	156	24	/	/	SYM
admet-258	156	25	ileum	ileum	NOUN
admet-258	156	26	,	,	PUNCT
admet-258	156	27	cecum	cecum	NOUN
admet-258	156	28	and	and	CCONJ
admet-258	156	29	colon	colon	NOUN
admet-258	156	30	,	,	PUNCT
admet-258	156	31	respectively	respectively	ADV
admet-258	156	32	.	.	PUNCT
admet-258	157	1	dilution	dilution	NOUN
admet-258	157	2	in	in	ADP
admet-258	157	3	the	the	DET
admet-258	157	4	stomach	stomach	NOUN
admet-258	157	5	is	be	AUX
admet-258	157	6	supposed	suppose	VERB
admet-258	157	7	to	to	PART
admet-258	157	8	be	be	AUX
admet-258	157	9	caused	cause	VERB
admet-258	157	10	by	by	ADP
admet-258	157	11	basal	basal	ADJ
admet-258	157	12	acid	acid	NOUN
admet-258	157	13	output	output	NOUN
admet-258	157	14	only	only	ADV
admet-258	157	15	.	.	PUNCT
admet-258	158	1	in	in	ADP
admet-258	158	2	the	the	DET
admet-258	158	3	small	small	ADJ
admet-258	158	4	intestine	intestine	NOUN
admet-258	158	5	,	,	PUNCT
admet-258	158	6	the	the	DET
admet-258	158	7	basal	basal	ADJ
admet-258	158	8	acid	acid	NOUN
admet-258	158	9	output	output	NOUN
admet-258	158	10	adds	add	VERB
admet-258	158	11	to	to	ADP
admet-258	158	12	the	the	DET
admet-258	158	13	secretion	secretion	NOUN
admet-258	158	14	of	of	ADP
admet-258	158	15	pancreatic	pancreatic	ADJ
admet-258	158	16	juice	juice	NOUN
admet-258	158	17	and	and	CCONJ
admet-258	158	18	bile	bile	NOUN
admet-258	158	19	.	.	PUNCT
admet-258	159	1	based	base	VERB
admet-258	159	2	on	on	ADP
admet-258	159	3	these	these	DET
admet-258	159	4	assumptions	assumption	NOUN
admet-258	159	5	,	,	PUNCT
admet-258	159	6	dilution	dilution	NOUN
admet-258	159	7	factors	factor	NOUN
admet-258	159	8	of	of	ADP
admet-258	159	9	1.5	1.5	NUM
admet-258	159	10	for	for	ADP
admet-258	159	11	the	the	DET
admet-258	159	12	stomach	stomach	NOUN
admet-258	159	13	,	,	PUNCT
admet-258	159	14	1.9	1.9	NUM
admet-258	159	15	for	for	ADP
admet-258	159	16	the	the	DET
admet-258	159	17	duodenum	duodenum	NOUN
admet-258	159	18	,	,	PUNCT
admet-258	159	19	5.8	5.8	NUM
admet-258	159	20	for	for	ADP
admet-258	159	21	jejunum	jejunum	NOUN
admet-258	159	22	/	/	SYM
admet-258	159	23	ileum	ileum	NOUN
admet-258	159	24	and	and	CCONJ
admet-258	159	25	2.9	2.9	NUM
admet-258	159	26	for	for	ADP
admet-258	159	27	the	the	DET
admet-258	159	28	cecum	cecum	NOUN
admet-258	159	29	were	be	AUX
admet-258	159	30	proposed	propose	VERB
admet-258	159	31	.	.	PUNCT
admet-258	160	1	no	no	DET
admet-258	160	2	further	further	ADJ
admet-258	160	3	dilution	dilution	NOUN
admet-258	160	4	was	be	AUX
admet-258	160	5	considered	consider	VERB
admet-258	160	6	in	in	ADP
admet-258	160	7	the	the	DET
admet-258	160	8	colon	colon	NOUN
admet-258	160	9	,	,	PUNCT
admet-258	160	10	since	since	SCONJ
admet-258	160	11	most	most	ADJ
admet-258	160	12	fluid	fluid	NOUN
admet-258	160	13	had	have	AUX
admet-258	160	14	been	be	AUX
admet-258	160	15	absorbed	absorb	VERB
admet-258	160	16	.	.	PUNCT
admet-258	161	1	for	for	ADP
admet-258	161	2	improved	improved	ADJ
admet-258	161	3	differentiation	differentiation	NOUN
admet-258	161	4	of	of	ADP
admet-258	161	5	weakly	weakly	ADJ
admet-258	161	6	basic	basic	ADJ
admet-258	161	7	compounds	compound	NOUN
admet-258	161	8	in	in	ADP
admet-258	161	9	our	our	PRON
admet-258	161	10	setup	setup	NOUN
admet-258	161	11	,	,	PUNCT
admet-258	161	12	the	the	DET
admet-258	161	13	ph	ph	NOUN
admet-258	161	14	of	of	ADP
admet-258	161	15	the	the	DET
admet-258	161	16	stomach	stomach	NOUN
admet-258	161	17	compartment	compartment	NOUN
admet-258	161	18	was	be	AUX
admet-258	161	19	lowered	lower	VERB
admet-258	161	20	to	to	ADP
admet-258	161	21	ph	ph	NOUN
admet-258	161	22	3	3	NUM
admet-258	161	23	.	.	PUNCT
admet-258	162	1	as	as	ADP
admet-258	162	2	dilution	dilution	NOUN
admet-258	162	3	medium	medium	NOUN
admet-258	162	4	the	the	DET
admet-258	162	5	rsif	rsif	NOUN
admet-258	162	6	as	as	SCONJ
admet-258	162	7	proposed	propose	VERB
admet-258	162	8	in	in	ADP
admet-258	162	9	table	table	NOUN
admet-258	162	10	2	2	NUM
admet-258	162	11	was	be	AUX
admet-258	162	12	used	use	VERB
admet-258	162	13	instead	instead	ADV
admet-258	162	14	of	of	ADP
admet-258	162	15	fassif	fassif	NOUN
admet-258	162	16	-	-	PUNCT
admet-258	162	17	v2	v2	NOUN
admet-258	162	18	.	.	PUNCT
admet-258	163	1	results	result	NOUN
admet-258	163	2	and	and	CCONJ
admet-258	163	3	discussion	discussion	NOUN
admet-258	163	4	in	in	ADP
admet-258	163	5	vitro	vitro	X
admet-258	163	6	solubility	solubility	NOUN
admet-258	163	7	studies	study	NOUN
admet-258	163	8	in	in	ADP
admet-258	163	9	order	order	NOUN
admet-258	163	10	to	to	PART
admet-258	163	11	study	study	VERB
admet-258	163	12	the	the	DET
admet-258	163	13	difference	difference	NOUN
admet-258	163	14	of	of	ADP
admet-258	163	15	equilibrium	equilibrium	NOUN
admet-258	163	16	solubility	solubility	NOUN
admet-258	163	17	in	in	ADP
admet-258	163	18	the	the	DET
admet-258	163	19	proposed	propose	VERB
admet-258	163	20	rat	rat	NOUN
admet-258	163	21	fluid	fluid	NOUN
admet-258	163	22	(	(	PUNCT
admet-258	163	23	rsif	rsif	NOUN
admet-258	163	24	)	)	PUNCT
admet-258	163	25	in	in	ADP
admet-258	163	26	comparison	comparison	NOUN
admet-258	163	27	to	to	PART
admet-258	163	28	buffer	buffer	VERB
admet-258	163	29	solubility	solubility	NOUN
admet-258	163	30	and	and	CCONJ
admet-258	163	31	human	human	ADJ
admet-258	163	32	fassif	fassif	NOUN
admet-258	163	33	-	-	PUNCT
admet-258	163	34	v2	v2	NOUN
admet-258	163	35	,	,	PUNCT
admet-258	163	36	a	a	DET
admet-258	163	37	set	set	NOUN
admet-258	163	38	of	of	ADP
admet-258	163	39	proprietary	proprietary	ADJ
admet-258	163	40	compounds	compound	NOUN
admet-258	163	41	has	have	AUX
admet-258	163	42	been	be	AUX
admet-258	163	43	investigated	investigate	VERB
admet-258	163	44	by	by	ADP
admet-258	163	45	the	the	DET
admet-258	163	46	shakeflask	shakeflask	NOUN
admet-258	163	47	method	method	NOUN
admet-258	163	48	.	.	PUNCT
admet-258	164	1	the	the	DET
admet-258	164	2	compounds	compound	NOUN
admet-258	164	3	have	have	AUX
admet-258	164	4	been	be	AUX
admet-258	164	5	selected	select	VERB
admet-258	164	6	based	base	VERB
admet-258	164	7	on	on	ADP
admet-258	164	8	availability	availability	NOUN
admet-258	164	9	of	of	ADP
admet-258	164	10	in	in	ADP
admet-258	164	11	vivo	vivo	ADJ
admet-258	164	12	data	datum	NOUN
admet-258	164	13	,	,	PUNCT
admet-258	164	14	and	and	CCONJ
admet-258	164	15	sufficient	sufficient	ADJ
admet-258	164	16	compound	compound	NOUN
admet-258	164	17	amount	amount	NOUN
admet-258	164	18	for	for	ADP
admet-258	164	19	running	run	VERB
admet-258	164	20	solubility	solubility	NOUN
admet-258	164	21	and	and	CCONJ
admet-258	164	22	gi	gi	VERB
admet-258	164	23	dissolution	dissolution	PROPN
admet-258	164	24	studies	study	NOUN
admet-258	164	25	.	.	PUNCT
admet-258	165	1	also	also	ADV
admet-258	165	2	,	,	PUNCT
admet-258	165	3	only	only	ADV
admet-258	165	4	compounds	compound	NOUN
admet-258	165	5	exhibiting	exhibit	VERB
admet-258	165	6	high	high	ADV
admet-258	165	7	in	in	ADP
admet-258	165	8	vitro	vitro	X
admet-258	165	9	permeability	permeability	NOUN
admet-258	165	10	have	have	AUX
admet-258	165	11	been	be	AUX
admet-258	165	12	chosen	choose	VERB
admet-258	165	13	,	,	PUNCT
admet-258	165	14	thus	thus	ADV
admet-258	165	15	keeping	keep	VERB
admet-258	165	16	the	the	DET
admet-258	165	17	impact	impact	NOUN
admet-258	165	18	of	of	ADP
admet-258	165	19	permeability	permeability	NOUN
admet-258	165	20	on	on	ADP
admet-258	165	21	drug	drug	NOUN
admet-258	165	22	absorption	absorption	NOUN
admet-258	165	23	low	low	ADJ
admet-258	165	24	.	.	PUNCT
admet-258	166	1	solubility	solubility	NOUN
admet-258	166	2	results	result	VERB
admet-258	166	3	in	in	ADP
admet-258	166	4	buffer	buffer	NOUN
admet-258	166	5	ph	ph	VERB
admet-258	166	6	6.8	6.8	NUM
admet-258	166	7	,	,	PUNCT
admet-258	166	8	human	human	ADJ
admet-258	166	9	fassif	fassif	NOUN
admet-258	166	10	-	-	PUNCT
admet-258	166	11	v2	v2	PROPN
admet-258	166	12	and	and	CCONJ
admet-258	166	13	rsif	rsif	NOUN
admet-258	166	14	media	medium	NOUN
admet-258	166	15	for	for	ADP
admet-258	166	16	the	the	DET
admet-258	166	17	selected	select	VERB
admet-258	166	18	compounds	compound	NOUN
admet-258	166	19	are	be	AUX
admet-258	166	20	summarized	summarize	VERB
admet-258	166	21	in	in	ADP
admet-258	166	22	table	table	NOUN
admet-258	166	23	3	3	NUM
admet-258	166	24	.	.	PUNCT
admet-258	166	25	table	table	NOUN
admet-258	166	26	3	3	NUM
admet-258	166	27	.	.	X
admet-258	167	1	solubility	solubility	NOUN
admet-258	167	2	(	(	PUNCT
admet-258	167	3	g	g	NOUN
admet-258	167	4	/	/	SYM
admet-258	167	5	l	l	NOUN
admet-258	167	6	)	)	PUNCT
admet-258	167	7	of	of	ADP
admet-258	167	8	selected	select	VERB
admet-258	167	9	compounds	compound	NOUN
admet-258	167	10	in	in	ADP
admet-258	167	11	buffer	buffer	NOUN
admet-258	167	12	ph	ph	VERB
admet-258	167	13	6.8	6.8	NUM
admet-258	167	14	,	,	PUNCT
admet-258	167	15	fassif	fassif	NOUN
admet-258	167	16	-	-	PUNCT
admet-258	167	17	v2	v2	NOUN
admet-258	167	18	in	in	ADP
admet-258	167	19	comparison	comparison	NOUN
admet-258	167	20	to	to	ADP
admet-258	167	21	rsif	rsif	NOUN
admet-258	167	22	buffer	buffer	NOUN
admet-258	167	23	ph	ph	NOUN
admet-258	167	24	6.8	6.8	NUM
admet-258	167	25	fassif	fassif	NOUN
admet-258	167	26	-	-	PUNCT
admet-258	167	27	v2	v2	NOUN
admet-258	167	28	rsif	rsif	NOUN
admet-258	167	29	compound	compound	VERB
admet-258	167	30	a	a	DET
admet-258	167	31	0.001	0.001	NUM
admet-258	167	32	0.0041	0.0041	NUM
admet-258	167	33	0.105	0.105	NUM
admet-258	167	34	compound	compound	NOUN
admet-258	167	35	b	b	NOUN
admet-258	167	36	0.004	0.004	NUM
admet-258	167	37	0.0001	0.0001	NUM
admet-258	167	38	0.448	0.448	NUM
admet-258	167	39	compound	compound	NOUN
admet-258	167	40	c	c	NOUN
admet-258	168	1	0.031	0.031	NUM
admet-258	168	2	0.043	0.043	NUM
admet-258	168	3	0.711	0.711	NUM
admet-258	168	4	compound	compound	NOUN
admet-258	168	5	d	d	NOUN
admet-258	168	6	0.005	0.005	NUM
admet-258	168	7	0.003	0.003	NUM
admet-258	168	8	0.023	0.023	NUM
admet-258	168	9	compound	compound	NOUN
admet-258	168	10	e	e	NOUN
admet-258	168	11	<	<	X
admet-258	168	12	0.0005	0.0005	NUM
admet-258	168	13	0.0009	0.0009	NUM
admet-258	168	14	0.046	0.046	NUM
admet-258	168	15	compound	compound	NOUN
admet-258	168	16	f	f	PROPN
admet-258	168	17	0.05	0.05	NUM
admet-258	168	18	0.14	0.14	NUM
admet-258	168	19	0.881	0.881	NUM
admet-258	168	20	compound	compound	NOUN
admet-258	168	21	g	g	ADP
admet-258	168	22	0.003	0.003	NUM
admet-258	168	23	0.013	0.013	NUM
admet-258	168	24	0.193	0.193	NUM
admet-258	168	25	compound	compound	NOUN
admet-258	168	26	h	h	NOUN
admet-258	168	27	0.0002	0.0002	NUM
admet-258	168	28	0.0005	0.0005	NUM
admet-258	168	29	0.01	0.01	NUM
admet-258	168	30	compound	compound	NOUN
admet-258	168	31	i	i	PRON
admet-258	168	32	0.0025	0.0025	NUM
admet-258	168	33	0.002	0.002	NUM
admet-258	168	34	0.015	0.015	NUM
admet-258	168	35	mostly	mostly	ADV
admet-258	168	36	compounds	compound	NOUN
admet-258	168	37	exhibiting	exhibit	VERB
admet-258	168	38	low	low	ADJ
admet-258	168	39	solubility	solubility	NOUN
admet-258	168	40	in	in	ADP
admet-258	168	41	both	both	DET
admet-258	168	42	buffer	buffer	NOUN
admet-258	168	43	ph	ph	NOUN
admet-258	168	44	6.8	6.8	NUM
admet-258	168	45	and	and	CCONJ
admet-258	168	46	fassif	fassif	NOUN
admet-258	168	47	-	-	PUNCT
admet-258	168	48	v2	v2	NOUN
admet-258	168	49	have	have	AUX
admet-258	168	50	been	be	AUX
admet-258	168	51	selected	select	VERB
admet-258	168	52	.	.	PUNCT
admet-258	169	1	solubility	solubility	NOUN
admet-258	169	2	in	in	ADP
admet-258	169	3	rsif	rsif	NOUN
admet-258	169	4	can	can	AUX
admet-258	169	5	differ	differ	VERB
admet-258	169	6	vastly	vastly	ADV
admet-258	169	7	from	from	ADP
admet-258	169	8	the	the	DET
admet-258	169	9	other	other	ADJ
admet-258	169	10	two	two	NUM
admet-258	169	11	media	medium	NOUN
admet-258	169	12	investigated	investigate	VERB
admet-258	169	13	,	,	PUNCT
admet-258	169	14	thus	thus	ADV
admet-258	169	15	leading	lead	VERB
admet-258	169	16	to	to	ADP
admet-258	169	17	the	the	DET
admet-258	169	18	assumption	assumption	NOUN
admet-258	169	19	admet	admet	PROPN
admet-258	169	20	&	&	CCONJ
admet-258	169	21	dmpk	dmpk	PROPN
admet-258	169	22	4(1	4(1	NOUN
admet-258	169	23	)	)	PUNCT
admet-258	169	24	(	(	PUNCT
admet-258	169	25	2016	2016	NUM
admet-258	169	26	)	)	PUNCT
admet-258	169	27	35	35	NUM
admet-258	169	28	-	-	SYM
admet-258	169	29	53	53	NUM
admet-258	169	30	simulated	simulate	VERB
admet-258	169	31	rat	rat	NOUN
admet-258	169	32	intestinal	intestinal	ADJ
admet-258	169	33	fluid	fluid	ADJ
admet-258	169	34	doi	doi	NOUN
admet-258	169	35	:	:	PUNCT
admet-258	169	36	10.5599	10.5599	NUM
admet-258	169	37	/	/	SYM
admet-258	169	38	admet.4.1.258	admet.4.1.258	NOUN
admet-258	169	39	43	43	NUM
admet-258	169	40	that	that	PRON
admet-258	169	41	fassif	fassif	VERB
admet-258	169	42	-	-	PUNCT
admet-258	169	43	v2	v2	NOUN
admet-258	169	44	solubility	solubility	NOUN
admet-258	169	45	is	be	AUX
admet-258	169	46	not	not	PART
admet-258	169	47	able	able	ADJ
admet-258	169	48	to	to	PART
admet-258	169	49	provide	provide	VERB
admet-258	169	50	a	a	DET
admet-258	169	51	realistic	realistic	ADJ
admet-258	169	52	input	input	NOUN
admet-258	169	53	parameter	parameter	NOUN
admet-258	169	54	for	for	ADP
admet-258	169	55	pbpk	pbpk	ADJ
admet-258	169	56	simulations	simulation	NOUN
admet-258	169	57	in	in	ADP
admet-258	169	58	the	the	DET
admet-258	169	59	rat	rat	NOUN
admet-258	169	60	.	.	PUNCT
admet-258	169	61	compound	compound	PROPN
admet-258	169	62	f	f	PROPN
admet-258	169	63	has	have	AUX
admet-258	169	64	been	be	AUX
admet-258	169	65	selected	select	VERB
admet-258	169	66	as	as	ADP
admet-258	169	67	an	an	DET
admet-258	169	68	example	example	NOUN
admet-258	169	69	of	of	ADP
admet-258	169	70	acceptable	acceptable	ADJ
admet-258	169	71	solubility	solubility	NOUN
admet-258	169	72	in	in	ADP
admet-258	169	73	fassif	fassif	NOUN
admet-258	169	74	-	-	PUNCT
admet-258	169	75	v2	v2	NOUN
admet-258	169	76	,	,	PUNCT
admet-258	169	77	but	but	CCONJ
admet-258	169	78	rsif	rsif	NOUN
admet-258	169	79	still	still	ADV
admet-258	169	80	showing	show	VERB
admet-258	169	81	a	a	DET
admet-258	169	82	7	7	NUM
admet-258	169	83	-	-	ADJ
admet-258	169	84	fold	fold	ADJ
admet-258	169	85	higher	high	ADJ
admet-258	169	86	equilibrium	equilibrium	NOUN
admet-258	169	87	value	value	NOUN
admet-258	169	88	.	.	PUNCT
admet-258	170	1	this	this	DET
admet-258	170	2	result	result	NOUN
admet-258	170	3	will	will	AUX
admet-258	170	4	be	be	AUX
admet-258	170	5	used	use	VERB
admet-258	170	6	as	as	ADP
admet-258	170	7	a	a	DET
admet-258	170	8	test	test	NOUN
admet-258	170	9	case	case	NOUN
admet-258	170	10	whether	whether	SCONJ
admet-258	170	11	solubility	solubility	NOUN
admet-258	170	12	in	in	ADP
admet-258	170	13	rsif	rsif	NOUN
admet-258	170	14	would	would	AUX
admet-258	170	15	lead	lead	VERB
admet-258	170	16	to	to	ADP
admet-258	170	17	over	over	ADP
admet-258	170	18	-	-	PUNCT
admet-258	170	19	prediction	prediction	NOUN
admet-258	170	20	in	in	ADP
admet-258	170	21	pbpk	pbpk	ADJ
admet-258	170	22	simulations	simulation	NOUN
admet-258	170	23	.	.	PUNCT
admet-258	171	1	bile	bile	NOUN
admet-258	171	2	salt	salt	NOUN
admet-258	171	3	dependent	dependent	ADJ
admet-258	171	4	solubility	solubility	NOUN
admet-258	171	5	there	there	PRON
admet-258	171	6	is	be	VERB
admet-258	171	7	little	little	ADJ
admet-258	171	8	doubt	doubt	NOUN
admet-258	171	9	that	that	SCONJ
admet-258	171	10	the	the	DET
admet-258	171	11	use	use	NOUN
admet-258	171	12	of	of	ADP
admet-258	171	13	thermodynamic	thermodynamic	ADJ
admet-258	171	14	solubility	solubility	NOUN
admet-258	171	15	values	value	NOUN
admet-258	171	16	in	in	ADP
admet-258	171	17	buffers	buffer	NOUN
admet-258	171	18	in	in	ADP
admet-258	171	19	many	many	ADJ
admet-258	171	20	cases	case	NOUN
admet-258	171	21	will	will	AUX
admet-258	171	22	not	not	PART
admet-258	171	23	be	be	AUX
admet-258	171	24	very	very	ADV
admet-258	171	25	useful	useful	ADJ
admet-258	171	26	to	to	PART
admet-258	171	27	predict	predict	VERB
admet-258	171	28	in	in	ADP
admet-258	171	29	vivo	vivo	ADJ
admet-258	171	30	concentration	concentration	NOUN
admet-258	171	31	-	-	PUNCT
admet-258	171	32	time	time	NOUN
admet-258	171	33	profiles	profile	NOUN
admet-258	171	34	.	.	PUNCT
admet-258	172	1	with	with	ADP
admet-258	172	2	the	the	DET
admet-258	172	3	exception	exception	NOUN
admet-258	172	4	of	of	ADP
admet-258	172	5	well	well	ADV
admet-258	172	6	soluble	soluble	ADJ
admet-258	172	7	compounds	compound	NOUN
admet-258	172	8	with	with	ADP
admet-258	172	9	good	good	ADJ
admet-258	172	10	wetting	wetting	NOUN
admet-258	172	11	properties	property	NOUN
admet-258	172	12	,	,	PUNCT
admet-258	172	13	buffer	buffer	VERB
admet-258	172	14	solubility	solubility	NOUN
admet-258	172	15	values	value	NOUN
admet-258	172	16	will	will	AUX
admet-258	172	17	most	most	ADV
admet-258	172	18	likely	likely	ADV
admet-258	172	19	underestimate	underestimate	VERB
admet-258	172	20	the	the	DET
admet-258	172	21	in	in	ADP
admet-258	172	22	vivo	vivo	ADJ
admet-258	172	23	solubilization	solubilization	NOUN
admet-258	172	24	of	of	ADP
admet-258	172	25	most	most	ADJ
admet-258	172	26	molecules	molecule	NOUN
admet-258	172	27	.	.	PUNCT
admet-258	173	1	since	since	SCONJ
admet-258	173	2	the	the	DET
admet-258	173	3	introduction	introduction	NOUN
admet-258	173	4	of	of	ADP
admet-258	173	5	the	the	DET
admet-258	173	6	human	human	ADJ
admet-258	173	7	fassif	fassif	NOUN
admet-258	173	8	and	and	CCONJ
admet-258	173	9	fessif	fessif	VERB
admet-258	173	10	media	medium	NOUN
admet-258	173	11	,	,	PUNCT
admet-258	173	12	there	there	PRON
admet-258	173	13	is	be	VERB
admet-258	173	14	an	an	DET
admet-258	173	15	option	option	NOUN
admet-258	173	16	to	to	PART
admet-258	173	17	obtain	obtain	VERB
admet-258	173	18	solubility	solubility	NOUN
admet-258	173	19	values	value	NOUN
admet-258	173	20	which	which	PRON
admet-258	173	21	are	be	AUX
admet-258	173	22	more	more	ADV
admet-258	173	23	appropriate	appropriate	ADJ
admet-258	173	24	as	as	ADP
admet-258	173	25	input	input	NOUN
admet-258	173	26	parameters	parameter	NOUN
admet-258	173	27	for	for	ADP
admet-258	173	28	pbpk	pbpk	NOUN
admet-258	173	29	simulations	simulation	NOUN
admet-258	173	30	and	and	CCONJ
admet-258	173	31	fassif	fassif	VERB
admet-258	173	32	solubility	solubility	NOUN
admet-258	173	33	maybe	maybe	ADV
admet-258	173	34	one	one	NUM
admet-258	173	35	of	of	ADP
admet-258	173	36	the	the	DET
admet-258	173	37	physico	physico	NOUN
admet-258	173	38	-	-	PUNCT
admet-258	173	39	chemical	chemical	NOUN
admet-258	173	40	parameters	parameter	NOUN
admet-258	173	41	that	that	PRON
admet-258	173	42	is	be	AUX
admet-258	173	43	determined	determine	VERB
admet-258	173	44	as	as	ADP
admet-258	173	45	one	one	NUM
admet-258	173	46	of	of	ADP
admet-258	173	47	the	the	DET
admet-258	173	48	first	first	ADJ
admet-258	173	49	after	after	SCONJ
admet-258	173	50	a	a	DET
admet-258	173	51	compound	compound	NOUN
admet-258	173	52	is	be	AUX
admet-258	173	53	sent	send	VERB
admet-258	173	54	out	out	ADP
admet-258	173	55	for	for	ADP
admet-258	173	56	characterization	characterization	NOUN
admet-258	173	57	.	.	PUNCT
admet-258	174	1	however	however	ADV
admet-258	174	2	,	,	PUNCT
admet-258	174	3	to	to	PART
admet-258	174	4	properly	properly	ADV
admet-258	174	5	assess	assess	VERB
admet-258	174	6	the	the	DET
admet-258	174	7	risk	risk	NOUN
admet-258	174	8	for	for	ADP
admet-258	174	9	clinical	clinical	ADJ
admet-258	174	10	development	development	NOUN
admet-258	174	11	it	it	PRON
admet-258	174	12	is	be	AUX
admet-258	174	13	necessary	necessary	ADJ
admet-258	174	14	to	to	PART
admet-258	174	15	understand	understand	VERB
admet-258	174	16	the	the	DET
admet-258	174	17	impact	impact	NOUN
admet-258	174	18	of	of	ADP
admet-258	174	19	solubility	solubility	NOUN
admet-258	174	20	on	on	ADP
admet-258	174	21	in	in	ADP
admet-258	174	22	vivo	vivo	ADJ
admet-258	174	23	absorption	absorption	NOUN
admet-258	174	24	during	during	ADP
admet-258	174	25	lead	lead	ADJ
admet-258	174	26	optimization	optimization	NOUN
admet-258	174	27	and	and	CCONJ
admet-258	174	28	thus	thus	ADV
admet-258	174	29	in	in	ADP
admet-258	174	30	preclinical	preclinical	ADJ
admet-258	174	31	species	specie	NOUN
admet-258	174	32	.	.	PUNCT
admet-258	175	1	although	although	SCONJ
admet-258	175	2	the	the	DET
admet-258	175	3	fassif	fassif	NOUN
admet-258	175	4	and	and	CCONJ
admet-258	175	5	fessif	fessif	VERB
admet-258	175	6	media	medium	NOUN
admet-258	175	7	allow	allow	VERB
admet-258	175	8	studying	study	VERB
admet-258	175	9	the	the	DET
admet-258	175	10	potential	potential	ADJ
admet-258	175	11	solubility	solubility	NOUN
admet-258	175	12	limitation	limitation	NOUN
admet-258	175	13	for	for	ADP
admet-258	175	14	absorption	absorption	NOUN
admet-258	175	15	in	in	ADP
admet-258	175	16	humans	human	NOUN
admet-258	175	17	,	,	PUNCT
admet-258	175	18	they	they	PRON
admet-258	175	19	may	may	AUX
admet-258	175	20	not	not	PART
admet-258	175	21	be	be	AUX
admet-258	175	22	appropriate	appropriate	ADJ
admet-258	175	23	input	input	NOUN
admet-258	175	24	parameters	parameter	NOUN
admet-258	175	25	in	in	ADP
admet-258	175	26	preclinical	preclinical	ADJ
admet-258	175	27	species	specie	NOUN
admet-258	175	28	.	.	PUNCT
admet-258	176	1	the	the	DET
admet-258	176	2	bile	bile	NOUN
admet-258	176	3	salt	salt	NOUN
admet-258	176	4	concentration	concentration	NOUN
admet-258	176	5	in	in	ADP
admet-258	176	6	gastrointestinal	gastrointestinal	ADJ
admet-258	176	7	fluids	fluid	NOUN
admet-258	176	8	in	in	ADP
admet-258	176	9	the	the	DET
admet-258	176	10	fasted	fast	VERB
admet-258	176	11	dog	dog	NOUN
admet-258	176	12	is	be	AUX
admet-258	176	13	known	know	VERB
admet-258	176	14	to	to	PART
admet-258	176	15	be	be	AUX
admet-258	176	16	at	at	ADP
admet-258	176	17	the	the	DET
admet-258	176	18	level	level	NOUN
admet-258	176	19	of	of	ADP
admet-258	176	20	human	human	ADJ
admet-258	176	21	fessif	fessif	NOUN
admet-258	176	22	rather	rather	ADV
admet-258	176	23	than	than	ADP
admet-258	176	24	fassif	fassif	NOUN
admet-258	176	25	[	[	X
admet-258	176	26	11	11	NUM
admet-258	176	27	]	]	PUNCT
admet-258	176	28	,	,	PUNCT
admet-258	176	29	and	and	CCONJ
admet-258	176	30	the	the	DET
admet-258	176	31	situation	situation	NOUN
admet-258	176	32	in	in	ADP
admet-258	176	33	rats	rat	NOUN
admet-258	176	34	is	be	AUX
admet-258	176	35	substantially	substantially	ADV
admet-258	176	36	different	different	ADJ
admet-258	176	37	.	.	PUNCT
admet-258	177	1	due	due	ADP
admet-258	177	2	to	to	ADP
admet-258	177	3	the	the	DET
admet-258	177	4	absence	absence	NOUN
admet-258	177	5	of	of	ADP
admet-258	177	6	a	a	DET
admet-258	177	7	gall	gall	NOUN
admet-258	177	8	bladder	bladder	NOUN
admet-258	177	9	and	and	CCONJ
admet-258	177	10	thus	thus	ADV
admet-258	177	11	a	a	DET
admet-258	177	12	constant	constant	ADJ
admet-258	177	13	bile	bile	NOUN
admet-258	177	14	flow	flow	NOUN
admet-258	177	15	,	,	PUNCT
admet-258	177	16	factors	factor	NOUN
admet-258	177	17	limiting	limit	VERB
admet-258	177	18	absorption	absorption	NOUN
admet-258	177	19	in	in	ADP
admet-258	177	20	a	a	DET
admet-258	177	21	rat	rat	NOUN
admet-258	177	22	may	may	AUX
admet-258	177	23	be	be	AUX
admet-258	177	24	rather	rather	ADV
admet-258	177	25	different	different	ADJ
admet-258	177	26	as	as	SCONJ
admet-258	177	27	compared	compare	VERB
admet-258	177	28	to	to	ADP
admet-258	177	29	the	the	DET
admet-258	177	30	situation	situation	NOUN
admet-258	177	31	in	in	ADP
admet-258	177	32	humans	human	NOUN
admet-258	177	33	.	.	PUNCT
admet-258	178	1	as	as	SCONJ
admet-258	178	2	bile	bile	NOUN
admet-258	178	3	salt	salt	NOUN
admet-258	178	4	concentrations	concentration	NOUN
admet-258	178	5	in	in	ADP
admet-258	178	6	rat	rat	NOUN
admet-258	178	7	gi	gi	NOUN
admet-258	178	8	fluids	fluid	NOUN
admet-258	178	9	are	be	AUX
admet-258	178	10	reported	report	VERB
admet-258	178	11	up	up	ADP
admet-258	178	12	to	to	ADP
admet-258	178	13	a	a	DET
admet-258	178	14	level	level	NOUN
admet-258	178	15	of	of	ADP
admet-258	178	16	51	51	NUM
admet-258	178	17	mm	mm	NOUN
admet-258	178	18	[	[	X
admet-258	178	19	9	9	NUM
admet-258	178	20	]	]	PUNCT
admet-258	178	21	the	the	DET
admet-258	178	22	rat	rat	NOUN
admet-258	178	23	is	be	AUX
admet-258	178	24	likely	likely	ADJ
admet-258	178	25	to	to	PART
admet-258	178	26	be	be	AUX
admet-258	178	27	a	a	DET
admet-258	178	28	better	well	ADJ
admet-258	178	29	solubilizer	solubilizer	NOUN
admet-258	178	30	for	for	ADP
admet-258	178	31	lipophilic	lipophilic	ADJ
admet-258	178	32	compounds	compound	NOUN
admet-258	178	33	which	which	PRON
admet-258	178	34	might	might	AUX
admet-258	178	35	be	be	AUX
admet-258	178	36	better	well	ADV
admet-258	178	37	absorbed	absorb	VERB
admet-258	178	38	than	than	ADP
admet-258	178	39	in	in	ADP
admet-258	178	40	higher	high	ADJ
admet-258	178	41	species	specie	NOUN
admet-258	178	42	.	.	PUNCT
admet-258	179	1	the	the	DET
admet-258	179	2	gastroplus	gastroplus	ADJ
admet-258	179	3	software	software	NOUN
admet-258	179	4	includes	include	VERB
admet-258	179	5	an	an	DET
admet-258	179	6	estimation	estimation	NOUN
admet-258	179	7	of	of	ADP
admet-258	179	8	bile	bile	NOUN
admet-258	179	9	salt	salt	NOUN
admet-258	179	10	dependent	dependent	ADJ
admet-258	179	11	solubility	solubility	NOUN
admet-258	179	12	based	base	VERB
admet-258	179	13	on	on	ADP
admet-258	179	14	log	log	PROPN
admet-258	179	15	p	p	NOUN
admet-258	179	16	according	accord	VERB
admet-258	179	17	to	to	ADP
admet-258	179	18	the	the	DET
admet-258	179	19	equation	equation	NOUN
admet-258	179	20	of	of	ADP
admet-258	179	21	mithani	mithani	PROPN
admet-258	179	22	et	et	PROPN
admet-258	179	23	al	al	PROPN
admet-258	179	24	.	.	PUNCT
admet-258	180	1	[	[	X
admet-258	180	2	20	20	NUM
admet-258	180	3	]	]	PUNCT
admet-258	180	4	:	:	PUNCT
admet-258	180	5	bs	bs	PROPN
admet-258	180	6	aq	aq	PROPN
admet-258	180	7	sc	sc	PROPN
admet-258	180	8	sr	sr	PROPN
admet-258	180	9	sc	sc	PROPN
admet-258	180	10			PROPN
admet-258	180	11	(	(	PUNCT
admet-258	180	12	2	2	NUM
admet-258	180	13	)	)	PUNCT
admet-258	180	14	where	where	SCONJ
admet-258	180	15	scbs	scbs	PROPN
admet-258	180	16	is	be	AUX
admet-258	180	17	defined	define	VERB
admet-258	180	18	as	as	ADP
admet-258	180	19	the	the	DET
admet-258	180	20	solubilization	solubilization	NOUN
admet-258	180	21	capacity	capacity	NOUN
admet-258	180	22	of	of	ADP
admet-258	180	23	bile	bile	NOUN
admet-258	180	24	salt	salt	NOUN
admet-258	180	25	(	(	PUNCT
admet-258	180	26	moles	mole	NOUN
admet-258	180	27	drug	drug	NOUN
admet-258	180	28	/	/	SYM
admet-258	180	29	mole	mole	NOUN
admet-258	180	30	bile	bile	NOUN
admet-258	180	31	salt	salt	NOUN
admet-258	180	32	)	)	PUNCT
admet-258	180	33	and	and	CCONJ
admet-258	180	34	scaq	scaq	NOUN
admet-258	180	35	is	be	AUX
admet-258	180	36	defined	define	VERB
admet-258	180	37	as	as	ADP
admet-258	180	38	the	the	DET
admet-258	180	39	solubilization	solubilization	NOUN
admet-258	180	40	capacity	capacity	NOUN
admet-258	180	41	of	of	ADP
admet-258	180	42	water	water	NOUN
admet-258	180	43	(	(	PUNCT
admet-258	180	44	moles	mole	NOUN
admet-258	180	45	drug	drug	NOUN
admet-258	180	46	/	/	SYM
admet-258	180	47	mole	mole	NOUN
admet-258	180	48	water	water	NOUN
admet-258	180	49	)	)	PUNCT
admet-258	180	50	.	.	PUNCT
admet-258	181	1	for	for	ADP
admet-258	181	2	their	their	PRON
admet-258	181	3	set	set	NOUN
admet-258	181	4	of	of	ADP
admet-258	181	5	compounds	compound	NOUN
admet-258	181	6	,	,	PUNCT
admet-258	181	7	they	they	PRON
admet-258	181	8	found	find	VERB
admet-258	181	9	:	:	PUNCT
admet-258	181	10	sr	sr	PROPN
admet-258	181	11	plog	plog	VERB
admet-258	181	12	2.23	2.23	NUM
admet-258	181	13	0.61log	0.61log	NUM
admet-258	181	14			PUNCT
admet-258	181	15	(	(	PUNCT
admet-258	181	16	3	3	X
admet-258	181	17	)	)	PUNCT
admet-258	181	18	this	this	DET
admet-258	181	19	approach	approach	NOUN
admet-258	181	20	was	be	AUX
admet-258	181	21	evaluated	evaluate	VERB
admet-258	181	22	based	base	VERB
admet-258	181	23	on	on	ADP
admet-258	181	24	a	a	DET
admet-258	181	25	dataset	dataset	NOUN
admet-258	181	26	of	of	ADP
admet-258	181	27	proprietary	proprietary	ADJ
admet-258	181	28	compounds	compound	NOUN
admet-258	181	29	.	.	PUNCT
admet-258	182	1	for	for	ADP
admet-258	182	2	these	these	DET
admet-258	182	3	compounds	compound	NOUN
admet-258	182	4	,	,	PUNCT
admet-258	182	5	buffer	buffer	VERB
admet-258	182	6	solubility	solubility	NOUN
admet-258	182	7	and	and	CCONJ
admet-258	182	8	the	the	DET
admet-258	182	9	solubility	solubility	NOUN
admet-258	182	10	in	in	ADP
admet-258	182	11	buffer	buffer	NOUN
admet-258	182	12	containing	contain	VERB
admet-258	182	13	various	various	ADJ
admet-258	182	14	amount	amount	NOUN
admet-258	182	15	of	of	ADP
admet-258	182	16	sodium	sodium	NOUN
admet-258	182	17	taurocholate	taurocholate	NOUN
admet-258	182	18	was	be	AUX
admet-258	182	19	determined	determine	VERB
admet-258	182	20	,	,	PUNCT
admet-258	182	21	see	see	VERB
admet-258	182	22	table	table	NOUN
admet-258	182	23	4	4	NUM
admet-258	182	24	.	.	PUNCT
admet-258	182	25	to	to	PART
admet-258	182	26	calculate	calculate	VERB
admet-258	182	27	scbs	scbs	PROPN
admet-258	182	28	,	,	PUNCT
admet-258	182	29	the	the	DET
admet-258	182	30	molar	molar	ADJ
admet-258	182	31	solubility	solubility	NOUN
admet-258	182	32	at	at	ADP
admet-258	182	33	a	a	DET
admet-258	182	34	defined	define	VERB
admet-258	182	35	bile	bile	NOUN
admet-258	182	36	salt	salt	NOUN
admet-258	182	37	concentration	concentration	NOUN
admet-258	182	38	was	be	AUX
admet-258	182	39	divided	divide	VERB
admet-258	182	40	by	by	ADP
admet-258	182	41	the	the	DET
admet-258	182	42	actual	actual	ADJ
admet-258	182	43	bile	bile	NOUN
admet-258	182	44	salt	salt	NOUN
admet-258	182	45	concentration	concentration	NOUN
admet-258	182	46	,	,	PUNCT
admet-258	182	47	i.e.	i.e.	X
admet-258	182	48	10	10	NUM
admet-258	182	49	,	,	PUNCT
admet-258	182	50	50	50	NUM
admet-258	182	51	or	or	CCONJ
admet-258	182	52	100	100	NUM
admet-258	182	53	mm	mm	NOUN
admet-258	182	54	in	in	ADP
admet-258	182	55	our	our	PRON
admet-258	182	56	data	datum	NOUN
admet-258	182	57	set	set	VERB
admet-258	182	58	.	.	PUNCT
admet-258	183	1	scaq	scaq	PROPN
admet-258	183	2	,	,	PUNCT
admet-258	183	3	correspondingly	correspondingly	ADV
admet-258	183	4	,	,	PUNCT
admet-258	183	5	is	be	AUX
admet-258	183	6	obtained	obtain	VERB
admet-258	183	7	by	by	ADP
admet-258	183	8	dividing	divide	VERB
admet-258	183	9	the	the	DET
admet-258	183	10	molar	molar	ADJ
admet-258	183	11	solubility	solubility	NOUN
admet-258	183	12	in	in	ADP
admet-258	183	13	buffer	buffer	NOUN
admet-258	183	14	ph	ph	X
admet-258	183	15	6.8	6.8	NUM
admet-258	183	16	by	by	ADP
admet-258	183	17	55.5	55.5	NUM
admet-258	183	18	mol	mol	NOUN
admet-258	183	19	/	/	SYM
admet-258	183	20	liter	liter	NOUN
admet-258	183	21	.	.	PUNCT
admet-258	184	1	calculation	calculation	NOUN
admet-258	184	2	of	of	ADP
admet-258	184	3	the	the	DET
admet-258	184	4	log	log	NOUN
admet-258	184	5	p	p	NOUN
admet-258	184	6	dependence	dependence	NOUN
admet-258	184	7	of	of	ADP
admet-258	184	8	the	the	DET
admet-258	184	9	solubility	solubility	NOUN
admet-258	184	10	ratio	ratio	NOUN
admet-258	184	11	(	(	PUNCT
admet-258	184	12	sr	sr	PROPN
admet-258	184	13	)	)	PUNCT
admet-258	184	14	as	as	SCONJ
admet-258	184	15	defined	define	VERB
admet-258	184	16	by	by	ADP
admet-258	184	17	mithani	mithani	PROPN
admet-258	184	18	et	et	PROPN
admet-258	184	19	al	al	PROPN
admet-258	184	20	.	.	PROPN
admet-258	184	21	led	lead	VERB
admet-258	184	22	to	to	ADP
admet-258	184	23	a	a	DET
admet-258	184	24	linear	linear	ADJ
admet-258	184	25	regression	regression	NOUN
admet-258	184	26	similarly	similarly	ADV
admet-258	184	27	to	to	ADP
admet-258	184	28	the	the	DET
admet-258	184	29	equation	equation	NOUN
admet-258	184	30	as	as	SCONJ
admet-258	184	31	proposed	propose	VERB
admet-258	184	32	by	by	ADP
admet-258	184	33	mithani	mithani	NOUN
admet-258	184	34	,	,	PUNCT
admet-258	184	35	see	see	VERB
admet-258	184	36	figure	figure	NOUN
admet-258	184	37	3	3	NUM
admet-258	184	38	.	.	PUNCT
admet-258	185	1	while	while	SCONJ
admet-258	185	2	this	this	DET
admet-258	185	3	data	datum	NOUN
admet-258	185	4	principally	principally	ADV
admet-258	185	5	berghausen	berghausen	VERB
admet-258	185	6	et	et	PROPN
admet-258	185	7	al	al	PROPN
admet-258	185	8	.	.	PROPN
admet-258	185	9	admet	admet	PROPN
admet-258	185	10	&	&	CCONJ
admet-258	185	11	dmpk	dmpk	PROPN
admet-258	185	12	4(1	4(1	NOUN
admet-258	185	13	)	)	PUNCT
admet-258	185	14	(	(	PUNCT
admet-258	185	15	2016	2016	NUM
admet-258	185	16	)	)	PUNCT
admet-258	185	17	35	35	NUM
admet-258	185	18	-	-	SYM
admet-258	185	19	53	53	NUM
admet-258	185	20	44	44	NUM
admet-258	185	21	supports	support	VERB
admet-258	185	22	the	the	DET
admet-258	185	23	linear	linear	ADJ
admet-258	185	24	dependency	dependency	NOUN
admet-258	185	25	of	of	ADP
admet-258	185	26	sr	sr	PROPN
admet-258	185	27	on	on	ADP
admet-258	185	28	log	log	NOUN
admet-258	185	29	p	p	X
admet-258	185	30	,	,	PUNCT
admet-258	185	31	this	this	DET
admet-258	185	32	equation	equation	NOUN
admet-258	185	33	is	be	AUX
admet-258	185	34	based	base	VERB
admet-258	185	35	on	on	ADP
admet-258	185	36	a	a	DET
admet-258	185	37	fit	fit	NOUN
admet-258	185	38	through	through	ADP
admet-258	185	39	several	several	ADJ
admet-258	185	40	orders	order	NOUN
admet-258	185	41	of	of	ADP
admet-258	185	42	magnitude	magnitude	NOUN
admet-258	185	43	for	for	ADP
admet-258	185	44	both	both	PRON
admet-258	185	45	log	log	VERB
admet-258	185	46	p	p	NOUN
admet-258	185	47	and	and	CCONJ
admet-258	185	48	log	log	VERB
admet-258	185	49	sr	sr	PROPN
admet-258	185	50	,	,	PUNCT
admet-258	185	51	which	which	PRON
admet-258	185	52	will	will	AUX
admet-258	185	53	compromise	compromise	VERB
admet-258	185	54	the	the	DET
admet-258	185	55	ability	ability	NOUN
admet-258	185	56	to	to	PART
admet-258	185	57	predict	predict	VERB
admet-258	185	58	individual	individual	ADJ
admet-258	185	59	solubility	solubility	NOUN
admet-258	185	60	values	value	NOUN
admet-258	185	61	with	with	ADP
admet-258	185	62	the	the	DET
admet-258	185	63	accuracy	accuracy	NOUN
admet-258	185	64	required	require	VERB
admet-258	185	65	for	for	ADP
admet-258	185	66	pbpk	pbpk	NOUN
admet-258	185	67	modeling	modeling	NOUN
admet-258	185	68	.	.	PUNCT
admet-258	186	1	in	in	ADP
admet-258	186	2	order	order	NOUN
admet-258	186	3	to	to	PART
admet-258	186	4	estimate	estimate	VERB
admet-258	186	5	the	the	DET
admet-258	186	6	predictive	predictive	ADJ
admet-258	186	7	power	power	NOUN
admet-258	186	8	of	of	ADP
admet-258	186	9	the	the	DET
admet-258	186	10	mithani	mithani	NOUN
admet-258	186	11	equation	equation	NOUN
admet-258	186	12	,	,	PUNCT
admet-258	186	13	the	the	DET
admet-258	186	14	calculated	calculated	ADJ
admet-258	186	15	values	value	NOUN
admet-258	186	16	and	and	CCONJ
admet-258	186	17	the	the	DET
admet-258	186	18	measured	measured	ADJ
admet-258	186	19	solubility	solubility	NOUN
admet-258	186	20	at	at	ADP
admet-258	186	21	different	different	ADJ
admet-258	186	22	bile	bile	NOUN
admet-258	186	23	salt	salt	NOUN
admet-258	186	24	concentrations	concentration	NOUN
admet-258	186	25	are	be	AUX
admet-258	186	26	displayed	display	VERB
admet-258	186	27	in	in	ADP
admet-258	186	28	figure	figure	NOUN
admet-258	186	29	3	3	NUM
admet-258	186	30	.	.	PUNCT
admet-258	187	1	for	for	ADP
admet-258	187	2	some	some	PRON
admet-258	187	3	of	of	ADP
admet-258	187	4	the	the	DET
admet-258	187	5	compounds	compound	NOUN
admet-258	187	6	of	of	ADP
admet-258	187	7	the	the	DET
admet-258	187	8	test	test	NOUN
admet-258	187	9	set	set	NOUN
admet-258	187	10	(	(	PUNCT
admet-258	187	11	see	see	VERB
admet-258	187	12	table	table	NOUN
admet-258	187	13	4	4	NUM
admet-258	187	14	)	)	PUNCT
admet-258	187	15	the	the	DET
admet-258	187	16	variation	variation	NOUN
admet-258	187	17	in	in	ADP
admet-258	187	18	sr	sr	PROPN
admet-258	187	19	can	can	AUX
admet-258	187	20	be	be	AUX
admet-258	187	21	more	more	ADJ
admet-258	187	22	than	than	ADP
admet-258	187	23	one	one	NUM
admet-258	187	24	order	order	NOUN
admet-258	187	25	of	of	ADP
admet-258	187	26	magnitude	magnitude	NOUN
admet-258	187	27	within	within	ADP
admet-258	187	28	the	the	DET
admet-258	187	29	different	different	ADJ
admet-258	187	30	concentration	concentration	NOUN
admet-258	187	31	of	of	ADP
admet-258	187	32	bile	bile	NOUN
admet-258	187	33	salts	salt	NOUN
admet-258	187	34	used	use	VERB
admet-258	187	35	to	to	PART
admet-258	187	36	determine	determine	VERB
admet-258	187	37	the	the	DET
admet-258	187	38	solubility	solubility	NOUN
admet-258	187	39	,	,	PUNCT
admet-258	187	40	i.e.	i.e.	X
admet-258	187	41	10	10	NUM
admet-258	187	42	,	,	PUNCT
admet-258	187	43	50	50	NUM
admet-258	187	44	or	or	CCONJ
admet-258	187	45	100	100	NUM
admet-258	187	46	mm	mm	NOUN
admet-258	187	47	.	.	PUNCT
admet-258	188	1	the	the	DET
admet-258	188	2	maximum	maximum	ADJ
admet-258	188	3	difference	difference	NOUN
admet-258	188	4	to	to	ADP
admet-258	188	5	the	the	DET
admet-258	188	6	linear	linear	ADJ
admet-258	188	7	fit	fit	NOUN
admet-258	188	8	is	be	AUX
admet-258	188	9	found	find	VERB
admet-258	188	10	to	to	PART
admet-258	188	11	be	be	AUX
admet-258	188	12	about	about	ADV
admet-258	188	13	2	2	NUM
admet-258	188	14	log	log	NOUN
admet-258	188	15	units	unit	NOUN
admet-258	188	16	of	of	ADP
admet-258	188	17	sr	sr	PROPN
admet-258	188	18	.	.	PUNCT
admet-258	189	1	importantly	importantly	ADV
admet-258	189	2	,	,	PUNCT
admet-258	189	3	the	the	DET
admet-258	189	4	differences	difference	NOUN
admet-258	189	5	to	to	ADP
admet-258	189	6	the	the	DET
admet-258	189	7	linear	linear	ADJ
admet-258	189	8	fit	fit	NOUN
admet-258	189	9	do	do	AUX
admet-258	189	10	not	not	PART
admet-258	189	11	appear	appear	VERB
admet-258	189	12	to	to	PART
admet-258	189	13	be	be	AUX
admet-258	189	14	markedly	markedly	ADV
admet-258	189	15	log	log	VERB
admet-258	189	16	p	p	NOUN
admet-258	189	17	dependent	dependent	ADV
admet-258	189	18	.	.	PUNCT
admet-258	190	1	also	also	ADV
admet-258	190	2	,	,	PUNCT
admet-258	190	3	the	the	DET
admet-258	190	4	increase	increase	NOUN
admet-258	190	5	in	in	ADP
admet-258	190	6	solubility	solubility	NOUN
admet-258	190	7	with	with	ADP
admet-258	190	8	increasing	increase	VERB
admet-258	190	9	bile	bile	NOUN
admet-258	190	10	salt	salt	NOUN
admet-258	190	11	concentration	concentration	NOUN
admet-258	190	12	for	for	ADP
admet-258	190	13	many	many	ADJ
admet-258	190	14	compounds	compound	NOUN
admet-258	190	15	is	be	AUX
admet-258	190	16	not	not	PART
admet-258	190	17	a	a	DET
admet-258	190	18	linear	linear	ADJ
admet-258	190	19	dependency	dependency	NOUN
admet-258	190	20	,	,	PUNCT
admet-258	190	21	see	see	VERB
admet-258	190	22	table	table	NOUN
admet-258	190	23	4	4	NUM
admet-258	190	24	.	.	PUNCT
admet-258	190	25	table	table	NOUN
admet-258	190	26	4	4	NUM
admet-258	190	27	.	.	X
admet-258	190	28	solubility	solubility	NOUN
admet-258	190	29	test	test	NOUN
admet-258	190	30	set	set	VERB
admet-258	190	31	for	for	ADP
admet-258	190	32	taurocholate	taurocholate	NOUN
admet-258	190	33	concentrations	concentration	NOUN
admet-258	190	34	of	of	ADP
admet-258	190	35	10	10	NUM
admet-258	190	36	,	,	PUNCT
admet-258	190	37	50	50	NUM
admet-258	190	38	and	and	CCONJ
admet-258	190	39	100	100	NUM
admet-258	190	40	mm	mm	NOUN
admet-258	190	41	.	.	PUNCT
admet-258	191	1	s	s	PART
admet-258	191	2	indicates	indicate	VERB
admet-258	191	3	solubility	solubility	NOUN
admet-258	191	4	in	in	ADP
admet-258	191	5	buffer	buffer	NOUN
admet-258	191	6	at	at	ADP
admet-258	191	7	ph	ph	PROPN
admet-258	191	8	6.8	6.8	NUM
admet-258	191	9	.	.	PUNCT
admet-258	192	1	calculated	calculate	VERB
admet-258	192	2	solubility	solubility	NOUN
admet-258	192	3	ratio	ratio	NOUN
admet-258	192	4	according	accord	VERB
admet-258	192	5	to	to	ADP
admet-258	192	6	taurocholate	taurocholate	NOUN
admet-258	192	7	concentrations	concentration	NOUN
admet-258	192	8	(	(	PUNCT
admet-258	192	9	log	log	PROPN
admet-258	192	10	sr10	sr10	PROPN
admet-258	192	11	,	,	PUNCT
admet-258	192	12	log	log	PROPN
admet-258	192	13	sr50	sr50	PROPN
admet-258	192	14	,	,	PUNCT
admet-258	192	15	log	log	NOUN
admet-258	192	16	sr100	sr100	PROPN
admet-258	192	17	)	)	PUNCT
admet-258	192	18	,	,	PUNCT
admet-258	192	19	based	base	VERB
admet-258	192	20	on	on	ADP
admet-258	192	21	the	the	DET
admet-258	192	22	mithani	mithani	ADJ
admet-258	192	23	equation	equation	NOUN
admet-258	192	24	(	(	PUNCT
admet-258	192	25	1	1	NUM
admet-258	192	26	)	)	PUNCT
admet-258	192	27	.	.	PUNCT
admet-258	193	1	mw	mw	VERB
admet-258	193	2	log	log	PROPN
admet-258	193	3	p	p	PROPN
admet-258	193	4	pka	pka	NOUN
admet-258	193	5	acid	acid	NOUN
admet-258	193	6	/	/	SYM
admet-258	193	7	base	base	NOUN
admet-258	193	8	s	s	PART
admet-258	193	9	/	/	SYM
admet-258	193	10	mm	mm	PROPN
admet-258	193	11	10	10	NUM
admet-258	193	12	mm	mm	NOUN
admet-258	193	13	50	50	NUM
admet-258	193	14	mm	mm	NOUN
admet-258	193	15	100	100	NUM
admet-258	193	16	mm	mm	NOUN
admet-258	193	17	log	log	NOUN
admet-258	193	18	sr10	sr10	PROPN
admet-258	193	19	log	log	NOUN
admet-258	193	20	sr50	sr50	PROPN
admet-258	193	21	log	log	NOUN
admet-258	193	22	sr100	sr100	PROPN
admet-258	193	23	cpd	cpd	NOUN
admet-258	193	24	1	1	NUM
admet-258	193	25	529.5	529.5	NUM
admet-258	193	26	5.2	5.2	NUM
admet-258	193	27	5.4b	5.4b	NOUN
admet-258	193	28	;	;	PUNCT
admet-258	193	29	3.9b	3.9b	NUM
admet-258	193	30	0.0019	0.0019	NUM
admet-258	193	31	17.78	17.78	NUM
admet-258	193	32	483.2	483.2	NUM
admet-258	193	33	666.9	666.9	NUM
admet-258	193	34	7.718	7.718	NUM
admet-258	193	35	8.453	8.453	NUM
admet-258	193	36	8.292	8.292	NUM
admet-258	193	37	cpd	cpd	NOUN
admet-258	193	38	2	2	NUM
admet-258	193	39	379.4	379.4	NUM
admet-258	193	40	3.2	3.2	NUM
admet-258	193	41	3.4b	3.4b	NUM
admet-258	193	42	0.022	0.022	NUM
admet-258	193	43	0.04	0.04	NUM
admet-258	193	44	0.26	0.26	NUM
admet-258	193	45	0.34	0.34	NUM
admet-258	193	46	4.004	4.004	NUM
admet-258	193	47	4.118	4.118	NUM
admet-258	193	48	3.933	3.933	NUM
admet-258	193	49	cpd	cpd	NOUN
admet-258	193	50	3	3	NUM
admet-258	193	51	560.5	560.5	NUM
admet-258	193	52	4.1	4.1	NUM
admet-258	193	53	8.2b	8.2b	NUM
admet-258	193	54	;	;	PUNCT
admet-258	193	55	3.7b	3.7b	NUM
admet-258	193	56	0.0054	0.0054	NUM
admet-258	193	57	0.42	0.42	NUM
admet-258	193	58	3.95	3.95	NUM
admet-258	193	59	5.49	5.49	NUM
admet-258	193	60	5.639	5.639	NUM
admet-258	193	61	5.913	5.913	NUM
admet-258	193	62	5.755	5.755	NUM
admet-258	193	63	cpd	cpd	NOUN
admet-258	193	64	4	4	NUM
admet-258	193	65	558.2	558.2	NUM
admet-258	193	66	4.6	4.6	NUM
admet-258	193	67	9.1b	9.1b	NUM
admet-258	193	68	;	;	PUNCT
admet-258	193	69	4.1b	4.1b	NUM
admet-258	193	70	0.001	0.001	NUM
admet-258	193	71	0.7	0.7	NUM
admet-258	193	72	4.12	4.12	NUM
admet-258	193	73	4.07	4.07	NUM
admet-258	193	74	6.589	6.589	NUM
admet-258	193	75	6.660	6.660	NUM
admet-258	193	76	6.354	6.354	NUM
admet-258	193	77	cpd	cpd	NOUN
admet-258	193	78	5	5	NUM
admet-258	193	79	577.8	577.8	NUM
admet-258	193	80	4.9	4.9	NUM
admet-258	193	81	9.1b	9.1b	NUM
admet-258	193	82	;	;	PUNCT
admet-258	193	83	3.9b	3.9b	NUM
admet-258	193	84	0.3202	0.3202	NUM
admet-258	193	85	10.8	10.8	NUM
admet-258	193	86	11.02	11.02	NUM
admet-258	193	87	11.23	11.23	NUM
admet-258	193	88	5.272	5.272	NUM
admet-258	193	89	4.582	4.582	NUM
admet-258	193	90	4.289	4.289	NUM
admet-258	193	91	cpd	cpd	NOUN
admet-258	193	92	6	6	NUM
admet-258	193	93	410.4	410.4	NUM
admet-258	193	94	2.6	2.6	NUM
admet-258	193	95	5.1b	5.1b	NUM
admet-258	193	96	0.0975	0.0975	NUM
admet-258	193	97	2.27	2.27	NUM
admet-258	193	98	4.35	4.35	NUM
admet-258	193	99	9.86	9.86	NUM
admet-258	193	100	5.111	5.111	NUM
admet-258	193	101	4.695	4.695	NUM
admet-258	193	102	4.749	4.749	NUM
admet-258	193	103	cpd	cpd	NOUN
admet-258	193	104	7	7	NUM
admet-258	193	105	485.5	485.5	NUM
admet-258	193	106	4.3	4.3	NUM
admet-258	193	107	4.2b	4.2b	NOUN
admet-258	193	108	0.001	0.001	NUM
admet-258	193	109	<	<	X
admet-258	193	110	0.001	0.001	NUM
admet-258	193	111	0.15	0.15	NUM
admet-258	193	112	0.34	0.34	NUM
admet-258	193	113	4.907	4.907	NUM
admet-258	193	114	4.962	4.962	NUM
admet-258	193	115	cpd	cpd	NOUN
admet-258	193	116	8	8	NUM
admet-258	193	117	453.6	453.6	NUM
admet-258	193	118	3.1	3.1	NUM
admet-258	193	119	3.7b	3.7b	NUM
admet-258	193	120	0.0066	0.0066	NUM
admet-258	193	121	0.01	0.01	NUM
admet-258	193	122	0.01	0.01	NUM
admet-258	193	123	0.01	0.01	NUM
admet-258	193	124	3.924	3.924	NUM
admet-258	193	125	3.225	3.225	NUM
admet-258	193	126	2.924	2.924	NUM
admet-258	193	127	cpd	cpd	NOUN
admet-258	193	128	9	9	NUM
admet-258	193	129	710.7	710.7	NUM
admet-258	193	130	7.1	7.1	NUM
admet-258	193	131	5.11a	5.11a	NUM
admet-258	193	132	;	;	PUNCT
admet-258	193	133	3.8b	3.8b	NUM
admet-258	193	134	0.0014	0.0014	NUM
admet-258	193	135	0.03	0.03	NUM
admet-258	193	136	1.27	1.27	NUM
admet-258	193	137	1.9	1.9	NUM
admet-258	193	138	5.073	5.073	NUM
admet-258	193	139	6.001	6.001	NUM
admet-258	193	140	5.875	5.875	NUM
admet-258	193	141	cpd	cpd	NOUN
admet-258	193	142	10	10	NUM
admet-258	193	143	313.4	313.4	NUM
admet-258	193	144	3.7	3.7	NUM
admet-258	193	145	n.d	n.d	PROPN
admet-258	193	146	.	.	PROPN
admet-258	193	147	0.16	0.16	NUM
admet-258	193	148	0.14	0.14	NUM
admet-258	193	149	1.6	1.6	NUM
admet-258	193	150	3.686	3.686	NUM
admet-258	193	151	4.045	4.045	NUM
admet-258	193	152	cpd	cpd	ADJ
admet-258	193	153	11	11	NUM
admet-258	193	154	361.3	361.3	NUM
admet-258	193	155	3.9	3.9	NUM
admet-258	193	156	11.7a	11.7a	NUM
admet-258	193	157	0.14	0.14	NUM
admet-258	193	158	0.46	0.46	NUM
admet-258	193	159	0.51	0.51	NUM
admet-258	193	160	0.63	0.63	NUM
admet-258	193	161	4.261	4.261	NUM
admet-258	193	162	3.607	3.607	NUM
admet-258	193	163	3.398	3.398	NUM
admet-258	193	164	y	y	NOUN
admet-258	193	165	=	=	SYM
admet-258	193	166	0.672x	0.672x	PROPN
admet-258	193	167	+	+	CCONJ
admet-258	194	1	2.1634	2.1634	NUM
admet-258	194	2	2	2	NUM
admet-258	194	3	3	3	NUM
admet-258	194	4	4	4	NUM
admet-258	194	5	5	5	NUM
admet-258	194	6	6	6	NUM
admet-258	194	7	7	7	NUM
admet-258	194	8	8	8	NUM
admet-258	194	9	9	9	NUM
admet-258	194	10	2	2	NUM
admet-258	194	11	3	3	NUM
admet-258	194	12	4	4	NUM
admet-258	194	13	5	5	NUM
admet-258	194	14	6	6	NUM
admet-258	194	15	7	7	NUM
admet-258	194	16	lo	lo	NOUN
admet-258	194	17	g	g	NOUN
admet-258	194	18	s	s	PROPN
admet-258	194	19	r	r	NOUN
admet-258	194	20	logp	logp	NOUN
admet-258	194	21	logsr10	logsr10	PROPN
admet-258	194	22	logsr50	logsr50	PROPN
admet-258	195	1	logsr100	logsr100	PROPN
admet-258	195	2	mithani	mithani	PROPN
admet-258	195	3	prediction	prediction	NOUN
admet-258	195	4	linear	linear	PROPN
admet-258	195	5	(	(	PUNCT
admet-258	195	6	logsr100	logsr100	PROPN
admet-258	195	7	)	)	PUNCT
admet-258	195	8	figure	figure	NOUN
admet-258	195	9	3	3	NUM
admet-258	195	10	.	.	PUNCT
admet-258	196	1	log	log	VERB
admet-258	196	2	p	p	NOUN
admet-258	196	3	dependence	dependence	NOUN
admet-258	196	4	of	of	ADP
admet-258	196	5	solubility	solubility	NOUN
admet-258	196	6	ratio	ratio	NOUN
admet-258	196	7	at	at	ADP
admet-258	196	8	10	10	NUM
admet-258	196	9	mm	mm	NOUN
admet-258	196	10	(	(	PUNCT
admet-258	196	11	log	log	PROPN
admet-258	196	12	sr10	sr10	PROPN
admet-258	196	13	)	)	PUNCT
admet-258	196	14	,	,	PUNCT
admet-258	196	15	50	50	NUM
admet-258	196	16	mm	mm	NOUN
admet-258	196	17	(	(	PUNCT
admet-258	196	18	log	log	PROPN
admet-258	196	19	sr50	sr50	PROPN
admet-258	196	20	)	)	PUNCT
admet-258	196	21	and	and	CCONJ
admet-258	196	22	100	100	NUM
admet-258	196	23	mm	mm	NOUN
admet-258	196	24	(	(	PUNCT
admet-258	196	25	logsr	logsr	ADJ
admet-258	196	26	100	100	NUM
admet-258	196	27	)	)	PUNCT
admet-258	196	28	taurocholate	taurocholate	NOUN
admet-258	196	29	concentration	concentration	NOUN
admet-258	196	30	.	.	PUNCT
admet-258	197	1	the	the	DET
admet-258	197	2	linear	linear	ADJ
admet-258	197	3	fit	fit	NOUN
admet-258	197	4	is	be	AUX
admet-258	197	5	based	base	VERB
admet-258	197	6	on	on	ADP
admet-258	197	7	log	log	PROPN
admet-258	197	8	sr100	sr100	PROPN
admet-258	197	9	,	,	PUNCT
admet-258	197	10	the	the	DET
admet-258	197	11	crosses	crosse	NOUN
admet-258	197	12	represent	represent	VERB
admet-258	197	13	the	the	DET
admet-258	197	14	prediction	prediction	NOUN
admet-258	197	15	according	accord	VERB
admet-258	197	16	to	to	ADP
admet-258	197	17	equation	equation	NOUN
admet-258	197	18	(	(	PUNCT
admet-258	197	19	2	2	NUM
admet-258	197	20	)	)	PUNCT
admet-258	197	21	.	.	PUNCT
admet-258	198	1	as	as	ADP
admet-258	198	2	a	a	DET
admet-258	198	3	consequence	consequence	NOUN
admet-258	198	4	,	,	PUNCT
admet-258	198	5	due	due	ADP
admet-258	198	6	to	to	ADP
admet-258	198	7	the	the	DET
admet-258	198	8	significant	significant	ADJ
admet-258	198	9	deviations	deviation	NOUN
admet-258	198	10	from	from	ADP
admet-258	198	11	the	the	DET
admet-258	198	12	linear	linear	ADJ
admet-258	198	13	fit	fit	NOUN
admet-258	198	14	for	for	ADP
admet-258	198	15	many	many	ADJ
admet-258	198	16	compounds	compound	NOUN
admet-258	198	17	,	,	PUNCT
admet-258	198	18	the	the	DET
admet-258	198	19	estimation	estimation	NOUN
admet-258	198	20	of	of	ADP
admet-258	198	21	bile	bile	NOUN
admet-258	198	22	salt	salt	NOUN
admet-258	198	23	solubility	solubility	NOUN
admet-258	198	24	for	for	ADP
admet-258	198	25	individual	individual	ADJ
admet-258	198	26	compounds	compound	NOUN
admet-258	198	27	is	be	AUX
admet-258	198	28	regarded	regard	VERB
admet-258	198	29	as	as	ADP
admet-258	198	30	not	not	PART
admet-258	198	31	sufficient	sufficient	ADJ
admet-258	198	32	to	to	PART
admet-258	198	33	support	support	VERB
admet-258	198	34	studying	study	VERB
admet-258	198	35	admet	admet	PROPN
admet-258	198	36	&	&	CCONJ
admet-258	198	37	dmpk	dmpk	PROPN
admet-258	198	38	4(1	4(1	NOUN
admet-258	198	39	)	)	PUNCT
admet-258	198	40	(	(	PUNCT
admet-258	198	41	2016	2016	NUM
admet-258	198	42	)	)	PUNCT
admet-258	198	43	35	35	NUM
admet-258	198	44	-	-	SYM
admet-258	198	45	53	53	NUM
admet-258	198	46	simulated	simulate	VERB
admet-258	198	47	rat	rat	NOUN
admet-258	198	48	intestinal	intestinal	ADJ
admet-258	198	49	fluid	fluid	ADJ
admet-258	198	50	doi	doi	NOUN
admet-258	198	51	:	:	PUNCT
admet-258	198	52	10.5599	10.5599	NUM
admet-258	198	53	/	/	SYM
admet-258	198	54	admet.4.1.258	admet.4.1.258	PROPN
admet-258	198	55	45	45	NUM
admet-258	198	56	the	the	DET
admet-258	198	57	impact	impact	NOUN
admet-258	198	58	of	of	ADP
admet-258	198	59	solubility	solubility	NOUN
admet-258	198	60	in	in	ADP
admet-258	198	61	pbpk	pbpk	ADJ
admet-258	198	62	simulations	simulation	NOUN
admet-258	198	63	.	.	PUNCT
admet-258	199	1	the	the	DET
admet-258	199	2	estimation	estimation	NOUN
admet-258	199	3	of	of	ADP
admet-258	199	4	log	log	NOUN
admet-258	199	5	p	p	NOUN
admet-258	199	6	dependent	dependent	ADJ
admet-258	199	7	solubilization	solubilization	NOUN
admet-258	199	8	ratio	ratio	NOUN
admet-258	199	9	might	might	AUX
admet-258	199	10	be	be	AUX
admet-258	199	11	justified	justify	VERB
admet-258	199	12	in	in	ADP
admet-258	199	13	cases	case	NOUN
admet-258	199	14	where	where	SCONJ
admet-258	199	15	no	no	DET
admet-258	199	16	bile	bile	NOUN
admet-258	199	17	salt	salt	NOUN
admet-258	199	18	dependent	dependent	ADJ
admet-258	199	19	solubility	solubility	NOUN
admet-258	199	20	can	can	AUX
admet-258	199	21	be	be	AUX
admet-258	199	22	determined	determine	VERB
admet-258	199	23	,	,	PUNCT
admet-258	199	24	however	however	ADV
admet-258	199	25	,	,	PUNCT
admet-258	199	26	there	there	PRON
admet-258	199	27	remains	remain	VERB
admet-258	199	28	a	a	DET
admet-258	199	29	risk	risk	NOUN
admet-258	199	30	of	of	ADP
admet-258	199	31	being	be	AUX
admet-258	199	32	misled	mislead	VERB
admet-258	199	33	.	.	PUNCT
admet-258	200	1	this	this	PRON
admet-258	200	2	is	be	AUX
admet-258	200	3	especially	especially	ADV
admet-258	200	4	true	true	ADJ
admet-258	200	5	for	for	ADP
admet-258	200	6	low	low	ADJ
admet-258	200	7	soluble	soluble	ADJ
admet-258	200	8	compounds	compound	NOUN
admet-258	200	9	,	,	PUNCT
admet-258	200	10	as	as	SCONJ
admet-258	200	11	changes	change	NOUN
admet-258	200	12	of	of	ADP
admet-258	200	13	solubility	solubility	NOUN
admet-258	200	14	by	by	ADP
admet-258	200	15	only	only	ADV
admet-258	200	16	a	a	DET
admet-258	200	17	factor	factor	NOUN
admet-258	200	18	2	2	NUM
admet-258	200	19	to	to	PART
admet-258	200	20	4	4	NUM
admet-258	200	21	might	might	AUX
admet-258	200	22	strongly	strongly	ADV
admet-258	200	23	impact	impact	VERB
admet-258	200	24	the	the	DET
admet-258	200	25	absorption	absorption	NOUN
admet-258	200	26	profile	profile	NOUN
admet-258	200	27	of	of	ADP
admet-258	200	28	a	a	DET
admet-258	200	29	compound	compound	NOUN
admet-258	200	30	.	.	PUNCT
admet-258	201	1	thus	thus	ADV
admet-258	201	2	,	,	PUNCT
admet-258	201	3	fassif	fassif	VERB
admet-258	201	4	solubility	solubility	NOUN
admet-258	201	5	will	will	AUX
admet-258	201	6	not	not	PART
admet-258	201	7	provide	provide	VERB
admet-258	201	8	accurate	accurate	ADJ
admet-258	201	9	enough	enough	ADJ
admet-258	201	10	information	information	NOUN
admet-258	201	11	to	to	PART
admet-258	201	12	further	far	ADV
admet-258	201	13	extrapolate	extrapolate	VERB
admet-258	201	14	the	the	DET
admet-258	201	15	contribution	contribution	NOUN
admet-258	201	16	of	of	ADP
admet-258	201	17	bile	bile	NOUN
admet-258	201	18	salt	salt	NOUN
admet-258	201	19	solubilization	solubilization	NOUN
admet-258	201	20	at	at	ADP
admet-258	201	21	concentrations	concentration	NOUN
admet-258	201	22	that	that	PRON
admet-258	201	23	are	be	AUX
admet-258	201	24	assumed	assume	VERB
admet-258	201	25	to	to	PART
admet-258	201	26	mimic	mimic	VERB
admet-258	201	27	the	the	DET
admet-258	201	28	in	in	ADP
admet-258	201	29	vivo	vivo	ADJ
admet-258	201	30	situation	situation	NOUN
admet-258	201	31	in	in	ADP
admet-258	201	32	rats	rat	NOUN
admet-258	201	33	.	.	PUNCT
admet-258	202	1	pbpk	pbpk	NOUN
admet-258	202	2	simulations	simulation	VERB
admet-258	202	3	the	the	DET
admet-258	202	4	importance	importance	NOUN
admet-258	202	5	of	of	ADP
admet-258	202	6	solubility	solubility	NOUN
admet-258	202	7	input	input	NOUN
admet-258	202	8	parameters	parameter	NOUN
admet-258	202	9	for	for	ADP
admet-258	202	10	pbpk	pbpk	NOUN
admet-258	202	11	simulations	simulation	NOUN
admet-258	202	12	of	of	ADP
admet-258	202	13	low	low	ADJ
admet-258	202	14	soluble	soluble	ADJ
admet-258	202	15	compounds	compound	NOUN
admet-258	202	16	is	be	AUX
admet-258	202	17	indisputable	indisputable	ADJ
admet-258	202	18	.	.	PUNCT
admet-258	203	1	at	at	ADP
admet-258	203	2	low	low	ADJ
admet-258	203	3	dose	dose	PROPN
admet-258	203	4	,	,	PUNCT
admet-258	203	5	a	a	DET
admet-258	203	6	significant	significant	ADJ
admet-258	203	7	portion	portion	NOUN
admet-258	203	8	of	of	ADP
admet-258	203	9	a	a	DET
admet-258	203	10	compound	compound	NOUN
admet-258	203	11	administered	administer	VERB
admet-258	203	12	might	might	AUX
admet-258	203	13	be	be	AUX
admet-258	203	14	dissolved	dissolve	VERB
admet-258	203	15	in	in	ADP
admet-258	203	16	the	the	DET
admet-258	203	17	stomach	stomach	NOUN
admet-258	203	18	and	and	CCONJ
admet-258	203	19	subsequently	subsequently	ADV
admet-258	203	20	be	be	AUX
admet-258	203	21	absorbed	absorb	VERB
admet-258	203	22	.	.	PUNCT
admet-258	204	1	however	however	ADV
admet-258	204	2	,	,	PUNCT
admet-258	204	3	at	at	ADP
admet-258	204	4	a	a	DET
admet-258	204	5	higher	high	ADJ
admet-258	204	6	dose	dose	NOUN
admet-258	204	7	,	,	PUNCT
admet-258	204	8	there	there	PRON
admet-258	204	9	is	be	VERB
admet-258	204	10	a	a	DET
admet-258	204	11	larger	large	ADJ
admet-258	204	12	portion	portion	NOUN
admet-258	204	13	remaining	remain	VERB
admet-258	204	14	undissolved	undissolve	VERB
admet-258	204	15	.	.	PUNCT
admet-258	205	1	thus	thus	ADV
admet-258	205	2	,	,	PUNCT
admet-258	205	3	the	the	DET
admet-258	205	4	solubilization	solubilization	NOUN
admet-258	205	5	power	power	NOUN
admet-258	205	6	of	of	ADP
admet-258	205	7	the	the	DET
admet-258	205	8	intestinal	intestinal	ADJ
admet-258	205	9	fluid	fluid	NOUN
admet-258	205	10	is	be	AUX
admet-258	205	11	more	more	ADV
admet-258	205	12	relevant	relevant	ADJ
admet-258	205	13	for	for	ADP
admet-258	205	14	the	the	DET
admet-258	205	15	absorption	absorption	NOUN
admet-258	205	16	of	of	ADP
admet-258	205	17	higher	high	ADJ
admet-258	205	18	doses	dose	NOUN
admet-258	205	19	.	.	PUNCT
admet-258	206	1	as	as	ADP
admet-258	206	2	a	a	DET
admet-258	206	3	consequence	consequence	NOUN
admet-258	206	4	,	,	PUNCT
admet-258	206	5	gi	gi	NOUN
admet-258	206	6	dissolution	dissolution	NOUN
admet-258	206	7	profiles	profile	NOUN
admet-258	206	8	adapted	adapt	VERB
admet-258	206	9	to	to	ADP
admet-258	206	10	the	the	DET
admet-258	206	11	relevant	relevant	ADJ
admet-258	206	12	species	specie	NOUN
admet-258	206	13	should	should	AUX
admet-258	206	14	positively	positively	ADV
admet-258	206	15	impact	impact	VERB
admet-258	206	16	the	the	DET
admet-258	206	17	prediction	prediction	NOUN
admet-258	206	18	results	result	NOUN
admet-258	206	19	,	,	PUNCT
admet-258	206	20	especially	especially	ADV
admet-258	206	21	for	for	ADP
admet-258	206	22	cmax	cmax	NOUN
admet-258	206	23	.	.	PUNCT
admet-258	207	1	to	to	PART
admet-258	207	2	test	test	VERB
admet-258	207	3	this	this	DET
admet-258	207	4	hypothesis	hypothesis	NOUN
admet-258	207	5	,	,	PUNCT
admet-258	207	6	gastroplus	gastroplus	ADJ
admet-258	207	7	simulations	simulation	NOUN
admet-258	207	8	have	have	AUX
admet-258	207	9	been	be	AUX
admet-258	207	10	performed	perform	VERB
admet-258	207	11	at	at	ADP
admet-258	207	12	different	different	ADJ
admet-258	207	13	dose	dose	NOUN
admet-258	207	14	levels	level	NOUN
admet-258	207	15	and	and	CCONJ
admet-258	207	16	simulation	simulation	NOUN
admet-258	207	17	results	result	NOUN
admet-258	207	18	are	be	AUX
admet-258	207	19	compared	compare	VERB
admet-258	207	20	to	to	ADP
admet-258	207	21	in	in	ADP
admet-258	207	22	vivo	vivo	ADJ
admet-258	207	23	results	result	NOUN
admet-258	207	24	.	.	PUNCT
admet-258	208	1	compounds	compound	NOUN
admet-258	208	2	with	with	ADP
admet-258	208	3	no	no	DET
admet-258	208	4	expected	expect	VERB
admet-258	208	5	permeability	permeability	NOUN
admet-258	208	6	limitation	limitation	NOUN
admet-258	208	7	according	accord	VERB
admet-258	208	8	to	to	ADP
admet-258	208	9	in	in	ADP
admet-258	208	10	vitro	vitro	X
admet-258	208	11	data	datum	NOUN
admet-258	208	12	(	(	PUNCT
admet-258	208	13	pampa	pampa	PROPN
admet-258	208	14	)	)	PUNCT
admet-258	208	15	and	and	CCONJ
admet-258	208	16	low	low	ADJ
admet-258	208	17	to	to	AUX
admet-258	208	18	moderate	moderate	ADJ
admet-258	208	19	total	total	ADJ
admet-258	208	20	blood	blood	NOUN
admet-258	208	21	clearance	clearance	NOUN
admet-258	208	22	have	have	AUX
admet-258	208	23	been	be	AUX
admet-258	208	24	selected	select	VERB
admet-258	208	25	to	to	PART
admet-258	208	26	investigate	investigate	VERB
admet-258	208	27	the	the	DET
admet-258	208	28	impact	impact	NOUN
admet-258	208	29	of	of	ADP
admet-258	208	30	solubility	solubility	NOUN
admet-258	208	31	parameters	parameter	NOUN
admet-258	208	32	on	on	ADP
admet-258	208	33	pbpk	pbpk	ADJ
admet-258	208	34	simulations	simulation	NOUN
admet-258	208	35	,	,	PUNCT
admet-258	208	36	see	see	VERB
admet-258	208	37	table	table	NOUN
admet-258	208	38	5	5	NUM
admet-258	208	39	.	.	PUNCT
admet-258	209	1	a	a	DET
admet-258	209	2	systematic	systematic	ADJ
admet-258	209	3	approach	approach	NOUN
admet-258	209	4	was	be	AUX
admet-258	209	5	chosen	choose	VERB
admet-258	209	6	to	to	PART
admet-258	209	7	compare	compare	VERB
admet-258	209	8	the	the	DET
admet-258	209	9	impact	impact	NOUN
admet-258	209	10	of	of	ADP
admet-258	209	11	solubility	solubility	NOUN
admet-258	209	12	on	on	ADP
admet-258	209	13	the	the	DET
admet-258	209	14	simulation	simulation	NOUN
admet-258	209	15	results	result	VERB
admet-258	209	16	for	for	ADP
admet-258	209	17	the	the	DET
admet-258	209	18	selected	select	VERB
admet-258	209	19	compounds	compound	NOUN
admet-258	209	20	.	.	PUNCT
admet-258	210	1	five	five	NUM
admet-258	210	2	different	different	ADJ
admet-258	210	3	solubility	solubility	NOUN
admet-258	210	4	input	input	NOUN
admet-258	210	5	parameters	parameter	NOUN
admet-258	210	6	have	have	AUX
admet-258	210	7	been	be	AUX
admet-258	210	8	chosen	choose	VERB
admet-258	210	9	.	.	PUNCT
admet-258	211	1	first	first	ADV
admet-258	211	2	,	,	PUNCT
admet-258	211	3	the	the	DET
admet-258	211	4	thermodynamic	thermodynamic	ADJ
admet-258	211	5	equilibrium	equilibrium	NOUN
admet-258	211	6	solubility	solubility	NOUN
admet-258	211	7	in	in	ADP
admet-258	211	8	buffer	buffer	NOUN
admet-258	211	9	was	be	AUX
admet-258	211	10	used	use	VERB
admet-258	211	11	,	,	PUNCT
admet-258	211	12	without	without	ADP
admet-258	211	13	correction	correction	NOUN
admet-258	211	14	for	for	ADP
admet-258	211	15	bile	bile	NOUN
admet-258	211	16	salt	salt	NOUN
admet-258	211	17	solubilization	solubilization	NOUN
admet-258	211	18	.	.	PUNCT
admet-258	212	1	in	in	ADP
admet-258	212	2	a	a	DET
admet-258	212	3	next	next	ADJ
admet-258	212	4	step	step	NOUN
admet-258	212	5	,	,	PUNCT
admet-258	212	6	the	the	DET
admet-258	212	7	fassif	fassif	PROPN
admet-258	212	8	solubilty	solubilty	NOUN
admet-258	212	9	value	value	NOUN
admet-258	212	10	was	be	AUX
admet-258	212	11	used	use	VERB
admet-258	212	12	to	to	PART
admet-258	212	13	calculate	calculate	VERB
admet-258	212	14	the	the	DET
admet-258	212	15	solubilization	solubilization	NOUN
admet-258	212	16	ratio	ratio	NOUN
admet-258	212	17	(	(	PUNCT
admet-258	212	18	sr	sr	PROPN
admet-258	212	19	)	)	PUNCT
admet-258	212	20	.	.	PUNCT
admet-258	213	1	based	base	VERB
admet-258	213	2	on	on	ADP
admet-258	213	3	the	the	DET
admet-258	213	4	data	datum	NOUN
admet-258	213	5	in	in	ADP
admet-258	213	6	table	table	NOUN
admet-258	213	7	4	4	NUM
admet-258	213	8	,	,	PUNCT
admet-258	213	9	the	the	DET
admet-258	213	10	theoretical	theoretical	ADJ
admet-258	213	11	sr	sr	PROPN
admet-258	213	12	calculation	calculation	NOUN
admet-258	213	13	as	as	SCONJ
admet-258	213	14	provided	provide	VERB
admet-258	213	15	by	by	ADP
admet-258	213	16	the	the	DET
admet-258	213	17	gastroplus	gastroplus	ADJ
admet-258	213	18	software	software	NOUN
admet-258	213	19	was	be	AUX
admet-258	213	20	tested	test	VERB
admet-258	213	21	in	in	ADP
admet-258	213	22	another	another	DET
admet-258	213	23	approach	approach	NOUN
admet-258	213	24	.	.	PUNCT
admet-258	214	1	the	the	DET
admet-258	214	2	rat	rat	NOUN
admet-258	214	3	sif	sif	PROPN
admet-258	214	4	fluid	fluid	NOUN
admet-258	214	5	solubility	solubility	NOUN
admet-258	214	6	was	be	AUX
admet-258	214	7	used	use	VERB
admet-258	214	8	without	without	ADP
admet-258	214	9	any	any	DET
admet-258	214	10	correction	correction	NOUN
admet-258	214	11	for	for	ADP
admet-258	214	12	bile	bile	NOUN
admet-258	214	13	salt	salt	NOUN
admet-258	214	14	content	content	NOUN
admet-258	214	15	,	,	PUNCT
admet-258	214	16	similar	similar	ADJ
admet-258	214	17	to	to	ADP
admet-258	214	18	the	the	DET
admet-258	214	19	thermodynamic	thermodynamic	ADJ
admet-258	214	20	solubility	solubility	NOUN
admet-258	214	21	value	value	NOUN
admet-258	214	22	.	.	PUNCT
admet-258	215	1	according	accord	VERB
admet-258	215	2	to	to	ADP
admet-258	215	3	the	the	DET
admet-258	215	4	authors	author	NOUN
admet-258	215	5	’	’	PART
admet-258	215	6	experience	experience	NOUN
admet-258	215	7	,	,	PUNCT
admet-258	215	8	correction	correction	NOUN
admet-258	215	9	of	of	ADP
admet-258	215	10	bile	bile	NOUN
admet-258	215	11	salt	salt	NOUN
admet-258	215	12	dependent	dependent	ADJ
admet-258	215	13	solubility	solubility	NOUN
admet-258	215	14	using	use	VERB
admet-258	215	15	the	the	DET
admet-258	215	16	built	build	VERB
admet-258	215	17	-	-	PUNCT
admet-258	215	18	in	in	NOUN
admet-258	215	19	in	in	ADP
admet-258	215	20	vitro	vitro	X
admet-258	215	21	sr	sr	PROPN
admet-258	215	22	calculation	calculation	NOUN
admet-258	215	23	compromises	compromise	VERB
admet-258	215	24	the	the	DET
admet-258	215	25	value	value	NOUN
admet-258	215	26	of	of	ADP
admet-258	215	27	the	the	DET
admet-258	215	28	solubility	solubility	NOUN
admet-258	215	29	in	in	ADP
admet-258	215	30	the	the	DET
admet-258	215	31	proposed	propose	VERB
admet-258	215	32	rat	rat	NOUN
admet-258	215	33	sif	sif	PROPN
admet-258	215	34	medium	medium	NOUN
admet-258	215	35	.	.	PUNCT
admet-258	216	1	finally	finally	ADV
admet-258	216	2	,	,	PUNCT
admet-258	216	3	if	if	SCONJ
admet-258	216	4	not	not	PART
admet-258	216	5	limited	limit	VERB
admet-258	216	6	by	by	ADP
admet-258	216	7	compound	compound	NOUN
admet-258	216	8	availability	availability	NOUN
admet-258	216	9	,	,	PUNCT
admet-258	216	10	the	the	DET
admet-258	216	11	full	full	ADJ
admet-258	216	12	dissolution	dissolution	NOUN
admet-258	216	13	curve	curve	NOUN
admet-258	216	14	was	be	AUX
admet-258	216	15	recorded	record	VERB
admet-258	216	16	to	to	PART
admet-258	216	17	mimic	mimic	VERB
admet-258	216	18	the	the	DET
admet-258	216	19	dissolution	dissolution	NOUN
admet-258	216	20	properties	property	NOUN
admet-258	216	21	of	of	ADP
admet-258	216	22	the	the	DET
admet-258	216	23	compound	compound	NOUN
admet-258	216	24	during	during	ADP
admet-258	216	25	its	its	PRON
admet-258	216	26	transit	transit	NOUN
admet-258	216	27	through	through	ADP
admet-258	216	28	the	the	DET
admet-258	216	29	rat	rat	NOUN
admet-258	216	30	gastrointestinal	gastrointestinal	ADJ
admet-258	216	31	tract	tract	NOUN
admet-258	216	32	,	,	PUNCT
admet-258	216	33	based	base	VERB
admet-258	216	34	on	on	ADP
admet-258	216	35	the	the	DET
admet-258	216	36	modified	modify	VERB
admet-258	216	37	procedure	procedure	NOUN
admet-258	216	38	of	of	ADP
admet-258	216	39	gao	gao	PROPN
admet-258	216	40	et	et	PROPN
admet-258	216	41	al.[6	al.[6	PROPN
admet-258	216	42	]	]	PUNCT
admet-258	216	43	.	.	PUNCT
admet-258	217	1	table	table	NOUN
admet-258	217	2	5	5	NUM
admet-258	217	3	.	.	PUNCT
admet-258	218	1	summary	summary	NOUN
admet-258	218	2	of	of	ADP
admet-258	218	3	input	input	NOUN
admet-258	218	4	parameters	parameter	NOUN
admet-258	218	5	for	for	ADP
admet-258	218	6	pbpk	pbpk	NOUN
admet-258	218	7	simulations	simulation	NOUN
admet-258	218	8	.	.	PUNCT
admet-258	219	1	first	first	ADV
admet-258	219	2	pass	pass	VERB
admet-258	219	3	extraction	extraction	NOUN
admet-258	219	4	ratio	ratio	NOUN
admet-258	219	5	(	(	PUNCT
admet-258	219	6	er%	er%	NUM
admet-258	219	7	)	)	PUNCT
admet-258	219	8	based	base	VERB
admet-258	219	9	on	on	ADP
admet-258	219	10	rat	rat	NOUN
admet-258	219	11	liver	liver	NOUN
admet-258	219	12	microsomes	microsome	NOUN
admet-258	219	13	.	.	PUNCT
admet-258	220	1	clearance	clearance	NOUN
admet-258	220	2	as	as	ADP
admet-258	220	3	a	a	DET
admet-258	220	4	result	result	NOUN
admet-258	220	5	of	of	ADP
admet-258	220	6	fit	fit	ADJ
admet-258	220	7	to	to	PART
admet-258	220	8	in	in	ADP
admet-258	220	9	vivo	vivo	ADJ
admet-258	220	10	data	datum	NOUN
admet-258	220	11	by	by	ADP
admet-258	220	12	the	the	DET
admet-258	220	13	pkplus	pkplus	NOUN
admet-258	220	14	module	module	NOUN
admet-258	220	15	.	.	PUNCT
admet-258	221	1	the	the	DET
admet-258	221	2	volume	volume	NOUN
admet-258	221	3	of	of	ADP
admet-258	221	4	distribution	distribution	NOUN
admet-258	221	5	into	into	ADP
admet-258	221	6	the	the	DET
admet-258	221	7	respective	respective	ADJ
admet-258	221	8	distribution	distribution	NOUN
admet-258	221	9	model	model	NOUN
admet-258	221	10	is	be	AUX
admet-258	221	11	given	give	VERB
admet-258	221	12	by	by	ADP
admet-258	221	13	vc	vc	PROPN
admet-258	221	14	,	,	PUNCT
admet-258	221	15	v2	v2	PROPN
admet-258	221	16	and	and	CCONJ
admet-258	221	17	v3	v3	PROPN
admet-258	221	18	.	.	PUNCT
admet-258	222	1	in	in	ADP
admet-258	222	2	case	case	NOUN
admet-258	222	3	only	only	ADV
admet-258	222	4	two	two	NUM
admet-258	222	5	numbers	number	NOUN
admet-258	222	6	are	be	AUX
admet-258	222	7	given	give	VERB
admet-258	222	8	,	,	PUNCT
admet-258	222	9	they	they	PRON
admet-258	222	10	refer	refer	VERB
admet-258	222	11	to	to	ADP
admet-258	222	12	vc	vc	PROPN
admet-258	222	13	and	and	CCONJ
admet-258	222	14	v2	v2	PROPN
admet-258	222	15	,	,	PUNCT
admet-258	222	16	respectively	respectively	ADV
admet-258	222	17	.	.	PUNCT
admet-258	223	1	first	first	ADV
admet-258	223	2	pass	pass	VERB
admet-258	223	3	er%	er%	NUM
admet-258	223	4	pka	pka	PROPN
admet-258	223	5	log	log	NOUN
admet-258	223	6	pampa	pampa	PROPN
admet-258	223	7	/	/	SYM
admet-258	223	8	cm	cm	NOUN
admet-258	223	9	/	/	SYM
admet-258	223	10	s	s	PART
admet-258	223	11	log	log	NOUN
admet-258	223	12	p	p	NOUN
admet-258	223	13	clearance	clearance	NOUN
admet-258	223	14	,	,	PUNCT
admet-258	223	15	l	l	NOUN
admet-258	223	16	/	/	SYM
admet-258	223	17	h	h	NOUN
admet-258	223	18	/	/	SYM
admet-258	223	19	kg	kg	PROPN
admet-258	223	20	vc	vc	PROPN
admet-258	223	21	,	,	PUNCT
admet-258	223	22	v2	v2	PROPN
admet-258	223	23	,	,	PUNCT
admet-258	223	24	v3	v3	PROPN
admet-258	223	25	compound	compound	VERB
admet-258	223	26	a	a	DET
admet-258	223	27	77	77	NUM
admet-258	223	28	3.8	3.8	NUM
admet-258	223	29	base	base	NOUN
admet-258	223	30	-3.9	-3.9	PROPN
admet-258	223	31	1.7	1.7	NUM
admet-258	223	32	0.42	0.42	NUM
admet-258	223	33	0.38	0.38	NUM
admet-258	223	34	,	,	PUNCT
admet-258	223	35	0.15	0.15	NUM
admet-258	223	36	,	,	PUNCT
admet-258	223	37	1.67	1.67	NUM
admet-258	223	38	compound	compound	NOUN
admet-258	223	39	b	b	PROPN
admet-258	223	40	28	28	NUM
admet-258	223	41	5.4	5.4	NUM
admet-258	223	42	acid	acid	NOUN
admet-258	223	43	-4.0	-4.0	PROPN
admet-258	223	44	3.7	3.7	NUM
admet-258	223	45	1.10	1.10	NUM
admet-258	223	46	3.28	3.28	NUM
admet-258	223	47	,	,	PUNCT
admet-258	223	48	4.58	4.58	NUM
admet-258	223	49	compound	compound	NOUN
admet-258	224	1	c	c	NOUN
admet-258	224	2	92	92	NUM
admet-258	225	1	<3	<3	NOUN
admet-258	225	2	base	base	NOUN
admet-258	225	3	-3.6	-3.6	PROPN
admet-258	225	4	3.6	3.6	NUM
admet-258	225	5	3.48	3.48	NUM
admet-258	225	6	2.77	2.77	NUM
admet-258	225	7	,	,	PUNCT
admet-258	225	8	0.95	0.95	NUM
admet-258	225	9	,	,	PUNCT
admet-258	225	10	1.74	1.74	NUM
admet-258	225	11	compound	compound	NOUN
admet-258	225	12	d	d	NOUN
admet-258	225	13	25	25	NUM
admet-258	225	14	4.7	4.7	NUM
admet-258	225	15	base	base	NOUN
admet-258	225	16	-3.6	-3.6	PROPN
admet-258	225	17	3.5	3.5	NUM
admet-258	225	18	0.98	0.98	NUM
admet-258	225	19	4.32	4.32	NUM
admet-258	225	20	,	,	PUNCT
admet-258	225	21	3.50	3.50	NUM
admet-258	225	22	,	,	PUNCT
admet-258	225	23	17.62	17.62	NUM
admet-258	225	24	compound	compound	NOUN
admet-258	225	25	e	e	NOUN
admet-258	225	26	56	56	NUM
admet-258	225	27	2.7	2.7	NUM
admet-258	225	28	base	base	NOUN
admet-258	225	29	-3.5	-3.5	PROPN
admet-258	225	30	4.2	4.2	NUM
admet-258	225	31	0.42	0.42	NUM
admet-258	225	32	0.88	0.88	NUM
admet-258	225	33	,	,	PUNCT
admet-258	225	34	2.19	2.19	NUM
admet-258	225	35	compound	compound	NOUN
admet-258	225	36	f	f	NOUN
admet-258	225	37	67	67	NUM
admet-258	225	38	3.2	3.2	NUM
admet-258	225	39	base	base	NOUN
admet-258	225	40	-3.4	-3.4	NOUN
admet-258	225	41	3.1	3.1	NUM
admet-258	225	42	0.42	0.42	NUM
admet-258	225	43	0.46	0.46	NUM
admet-258	225	44	,	,	PUNCT
admet-258	225	45	0.47	0.47	NUM
admet-258	225	46	compound	compound	NOUN
admet-258	225	47	g	g	ADP
admet-258	225	48	55	55	NUM
admet-258	225	49	3.4	3.4	NUM
admet-258	225	50	base	base	NOUN
admet-258	225	51	-4.6	-4.6	NOUN
admet-258	225	52	3.9	3.9	NUM
admet-258	225	53	3.36	3.36	NUM
admet-258	225	54	4.50	4.50	NUM
admet-258	225	55	,	,	PUNCT
admet-258	225	56	0.80	0.80	NUM
admet-258	225	57	compound	compound	NOUN
admet-258	225	58	h	h	NOUN
admet-258	225	59	38	38	NUM
admet-258	225	60	3.5	3.5	NUM
admet-258	225	61	base	base	NOUN
admet-258	225	62	-4.5	-4.5	VERB
admet-258	225	63	5.3	5.3	NUM
admet-258	225	64	1.34	1.34	NUM
admet-258	225	65	3.74	3.74	NUM
admet-258	225	66	,	,	PUNCT
admet-258	225	67	7.19	7.19	NUM
admet-258	225	68	compound	compound	NOUN
admet-258	225	69	i	i	PRON
admet-258	225	70	37	37	NUM
admet-258	225	71	1.7	1.7	NUM
admet-258	225	72	base	base	NOUN
admet-258	225	73	-4.2	-4.2	NOUN
admet-258	225	74	2.8	2.8	NUM
admet-258	225	75	5.19	5.19	NUM
admet-258	225	76	2.57	2.57	NUM
admet-258	225	77	,	,	PUNCT
admet-258	225	78	0.55	0.55	NUM
admet-258	225	79	berghausen	berghausen	VERB
admet-258	225	80	et	et	PROPN
admet-258	225	81	al	al	PROPN
admet-258	225	82	.	.	PROPN
admet-258	225	83	admet	admet	PROPN
admet-258	225	84	&	&	CCONJ
admet-258	225	85	dmpk	dmpk	PROPN
admet-258	225	86	4(1	4(1	NOUN
admet-258	225	87	)	)	PUNCT
admet-258	225	88	(	(	PUNCT
admet-258	225	89	2016	2016	NUM
admet-258	225	90	)	)	PUNCT
admet-258	225	91	35	35	NUM
admet-258	225	92	-	-	SYM
admet-258	225	93	53	53	NUM
admet-258	225	94	46	46	NUM
admet-258	225	95	the	the	DET
admet-258	225	96	pbpk	pbpk	PROPN
admet-258	225	97	simulation	simulation	NOUN
admet-258	225	98	results	result	NOUN
admet-258	225	99	based	base	VERB
admet-258	225	100	on	on	ADP
admet-258	225	101	the	the	DET
admet-258	225	102	acat	acat	PROPN
admet-258	225	103	model	model	NOUN
admet-258	225	104	have	have	AUX
admet-258	225	105	been	be	AUX
admet-258	225	106	split	split	VERB
admet-258	225	107	into	into	ADP
admet-258	225	108	lower	low	ADJ
admet-258	225	109	and	and	CCONJ
admet-258	225	110	higher	high	ADJ
admet-258	225	111	dose	dose	NOUN
admet-258	225	112	studies	study	NOUN
admet-258	225	113	and	and	CCONJ
admet-258	225	114	are	be	AUX
admet-258	225	115	summarized	summarize	VERB
admet-258	225	116	in	in	ADP
admet-258	225	117	tables	table	NOUN
admet-258	225	118	6	6	NUM
admet-258	225	119	to	to	PART
admet-258	225	120	9	9	NUM
admet-258	225	121	.	.	PUNCT
admet-258	226	1	simulation	simulation	NOUN
admet-258	226	2	results	result	NOUN
admet-258	226	3	are	be	AUX
admet-258	226	4	compared	compare	VERB
admet-258	226	5	to	to	ADP
admet-258	226	6	in	in	ADP
admet-258	226	7	vivo	vivo	ADJ
admet-258	226	8	data	datum	NOUN
admet-258	226	9	from	from	ADP
admet-258	226	10	compounds	compound	NOUN
admet-258	226	11	dosed	dose	VERB
admet-258	226	12	orally	orally	ADV
admet-258	226	13	as	as	ADP
admet-258	226	14	suspension	suspension	NOUN
admet-258	226	15	.	.	PUNCT
admet-258	227	1	pbpk	pbpk	PROPN
admet-258	227	2	results	result	VERB
admet-258	227	3	lower	low	ADJ
admet-258	227	4	range	range	NOUN
admet-258	227	5	of	of	ADP
admet-258	227	6	p.o	p.o	PROPN
admet-258	227	7	.	.	PROPN
admet-258	227	8	doses	dose	VERB
admet-258	227	9	the	the	DET
admet-258	227	10	impact	impact	NOUN
admet-258	227	11	of	of	ADP
admet-258	227	12	various	various	ADJ
admet-258	227	13	solubility	solubility	NOUN
admet-258	227	14	input	input	NOUN
admet-258	227	15	parameters	parameter	NOUN
admet-258	227	16	on	on	ADP
admet-258	227	17	pbpk	pbpk	PROPN
admet-258	227	18	simulation	simulation	NOUN
admet-258	227	19	results	result	NOUN
admet-258	227	20	has	have	AUX
admet-258	227	21	been	be	AUX
admet-258	227	22	tested	test	VERB
admet-258	227	23	.	.	PUNCT
admet-258	228	1	as	as	SCONJ
admet-258	228	2	evaluation	evaluation	NOUN
admet-258	228	3	criteria	criterion	NOUN
admet-258	228	4	for	for	ADP
admet-258	228	5	the	the	DET
admet-258	228	6	success	success	NOUN
admet-258	228	7	of	of	ADP
admet-258	228	8	pbpk	pbpk	ADJ
admet-258	228	9	simulations	simulation	NOUN
admet-258	228	10	versus	versus	ADP
admet-258	228	11	the	the	DET
admet-258	228	12	in	in	ADP
admet-258	228	13	vivo	vivo	ADJ
admet-258	228	14	pk	pk	NOUN
admet-258	228	15	results	result	NOUN
admet-258	228	16	,	,	PUNCT
admet-258	228	17	cmax	cmax	NOUN
admet-258	228	18	and	and	CCONJ
admet-258	228	19	auc	auc	NOUN
admet-258	228	20	were	be	AUX
admet-258	228	21	chosen	choose	VERB
admet-258	228	22	,	,	PUNCT
admet-258	228	23	see	see	VERB
admet-258	228	24	table	table	NOUN
admet-258	228	25	6	6	NUM
admet-258	228	26	and	and	CCONJ
admet-258	228	27	table	table	NOUN
admet-258	228	28	7	7	NUM
admet-258	228	29	.	.	PUNCT
admet-258	229	1	different	different	ADJ
admet-258	229	2	solubility	solubility	NOUN
admet-258	229	3	input	input	NOUN
admet-258	229	4	parameters	parameter	NOUN
admet-258	229	5	have	have	AUX
admet-258	229	6	been	be	AUX
admet-258	229	7	tested	test	VERB
admet-258	229	8	,	,	PUNCT
admet-258	229	9	as	as	SCONJ
admet-258	229	10	described	describe	VERB
admet-258	229	11	above	above	ADV
admet-258	229	12	(	(	PUNCT
admet-258	229	13	see	see	VERB
admet-258	229	14	table	table	NOUN
admet-258	229	15	3	3	NUM
admet-258	229	16	)	)	PUNCT
admet-258	229	17	.	.	PUNCT
admet-258	230	1	in	in	ADP
admet-258	230	2	addition	addition	NOUN
admet-258	230	3	,	,	PUNCT
admet-258	230	4	the	the	DET
admet-258	230	5	full	full	ADJ
admet-258	230	6	gi	gi	NOUN
admet-258	230	7	dissolution	dissolution	NOUN
admet-258	230	8	profile	profile	NOUN
admet-258	230	9	at	at	ADP
admet-258	230	10	the	the	DET
admet-258	230	11	respective	respective	ADJ
admet-258	230	12	dose	dose	NOUN
admet-258	230	13	has	have	AUX
admet-258	230	14	been	be	AUX
admet-258	230	15	measured	measure	VERB
admet-258	230	16	and	and	CCONJ
admet-258	230	17	the	the	DET
admet-258	230	18	solubility	solubility	NOUN
admet-258	230	19	values	value	NOUN
admet-258	230	20	for	for	ADP
admet-258	230	21	each	each	DET
admet-258	230	22	compartment	compartment	NOUN
admet-258	230	23	have	have	AUX
admet-258	230	24	been	be	AUX
admet-258	230	25	entered	enter	VERB
admet-258	230	26	according	accord	VERB
admet-258	230	27	to	to	ADP
admet-258	230	28	the	the	DET
admet-258	230	29	method	method	NOUN
admet-258	230	30	section	section	NOUN
admet-258	230	31	.	.	PUNCT
admet-258	231	1	table	table	NOUN
admet-258	231	2	6	6	NUM
admet-258	231	3	.	.	PUNCT
admet-258	232	1	pbpk	pbpk	PROPN
admet-258	232	2	results	result	NOUN
admet-258	232	3	of	of	ADP
admet-258	232	4	cmax	cmax	NOUN
admet-258	232	5	in	in	ADP
admet-258	232	6	g	g	PROPN
admet-258	232	7	/	/	SYM
admet-258	232	8	ml	ml	X
admet-258	232	9	for	for	ADP
admet-258	232	10	lower	low	ADJ
admet-258	232	11	dose	dose	NOUN
admet-258	232	12	range	range	NOUN
admet-258	232	13	based	base	VERB
admet-258	232	14	on	on	ADP
admet-258	232	15	various	various	ADJ
admet-258	232	16	solubility	solubility	NOUN
admet-258	232	17	input	input	NOUN
admet-258	232	18	.	.	PUNCT
admet-258	233	1	cmax	cmax	NOUN
admet-258	233	2	buffer	buffer	NOUN
admet-258	233	3	,	,	PUNCT
admet-258	233	4	fassif	fassif	VERB
admet-258	233	5	,	,	PUNCT
admet-258	233	6	fassif	fassif	VERB
admet-258	233	7	with	with	ADP
admet-258	233	8	theoretical	theoretical	ADJ
admet-258	233	9	bile	bile	NOUN
admet-258	233	10	salt	salt	NOUN
admet-258	233	11	correction	correction	NOUN
admet-258	233	12	(	(	PUNCT
admet-258	233	13	cmax	cmax	NOUN
admet-258	233	14	fassif	fassif	VERB
admet-258	233	15	bile	bile	NOUN
admet-258	233	16	)	)	PUNCT
admet-258	233	17	and	and	CCONJ
admet-258	233	18	rsif	rsif	NOUN
admet-258	233	19	refer	refer	VERB
admet-258	233	20	to	to	ADP
admet-258	233	21	equilibrium	equilibrium	NOUN
admet-258	233	22	values	value	NOUN
admet-258	233	23	,	,	PUNCT
admet-258	233	24	whereas	whereas	SCONJ
admet-258	233	25	gi	gi	NOUN
admet-258	233	26	disso	disso	PROPN
admet-258	233	27	comprises	comprise	VERB
admet-258	233	28	the	the	DET
admet-258	233	29	input	input	NOUN
admet-258	233	30	of	of	ADP
admet-258	233	31	the	the	DET
admet-258	233	32	full	full	ADJ
admet-258	233	33	gi	gi	NOUN
admet-258	233	34	dissolution	dissolution	NOUN
admet-258	233	35	profile	profile	NOUN
admet-258	233	36	.	.	PUNCT
admet-258	234	1	pred	pre	VERB
admet-258	234	2	.	.	PUNCT
admet-258	235	1	vs.	vs.	X
admet-258	235	2	obs	obs	PROPN
admet-258	235	3	.	.	PUNCT
admet-258	236	1	denotes	denote	VERB
admet-258	236	2	the	the	DET
admet-258	236	3	ratio	ratio	NOUN
admet-258	236	4	of	of	ADP
admet-258	236	5	the	the	DET
admet-258	236	6	predicted	predict	VERB
admet-258	236	7	values	value	NOUN
admet-258	236	8	vs.	vs.	ADP
admet-258	236	9	the	the	DET
admet-258	236	10	observed	observed	ADJ
admet-258	236	11	cmax	cmax	NOUN
admet-258	236	12	.	.	PUNCT
admet-258	237	1	dose	dose	VERB
admet-258	237	2	mg	mg	PROPN
admet-258	237	3	/	/	SYM
admet-258	237	4	kg	kg	PROPN
admet-258	237	5	cmax	cmax	NOUN
admet-258	237	6	obs	obs	PROPN
admet-258	237	7	cmax	cmax	NOUN
admet-258	237	8	buffer	buffer	NOUN
admet-258	237	9	cmax	cmax	NOUN
admet-258	237	10	fassif	fassif	NOUN
admet-258	237	11	cmax	cmax	NOUN
admet-258	237	12	fassif	fassif	VERB
admet-258	237	13	bile	bile	NOUN
admet-258	237	14	cmax	cmax	NOUN
admet-258	237	15	rsif	rsif	NOUN
admet-258	237	16	cmax	cmax	AUX
admet-258	237	17	gi	gi	X
admet-258	237	18	disso	disso	PROPN
admet-258	237	19	compound	compound	VERB
admet-258	237	20	a	a	DET
admet-258	237	21	10	10	NUM
admet-258	237	22	5.041	5.041	NUM
admet-258	237	23	0.035	0.035	NUM
admet-258	237	24	0.273	0.273	NUM
admet-258	237	25	0.089	0.089	NUM
admet-258	237	26	2.185	2.185	NUM
admet-258	237	27	pred	pre	VERB
admet-258	237	28	.	.	PUNCT
admet-258	238	1	vs.	vs.	X
admet-258	238	2	obs	obs	PROPN
admet-258	238	3	.	.	PUNCT
admet-258	239	1	0.0069	0.0069	NUM
admet-258	239	2	0.0542	0.0542	NUM
admet-258	239	3	0.0175	0.0175	NUM
admet-258	239	4	0.4333	0.4333	NUM
admet-258	239	5	compound	compound	NOUN
admet-258	239	6	b	b	NOUN
admet-258	239	7	3	3	NUM
admet-258	239	8	0.138	0.138	NUM
admet-258	239	9	0.012	0.012	NUM
admet-258	239	10	0.012	0.012	NUM
admet-258	239	11	0.040	0.040	NUM
admet-258	239	12	0.238	0.238	NUM
admet-258	239	13	pred	pre	VERB
admet-258	239	14	.	.	PUNCT
admet-258	240	1	vs.	vs.	X
admet-258	240	2	obs	obs	PROPN
admet-258	240	3	.	.	PUNCT
admet-258	241	1	0.0869	0.0869	NUM
admet-258	241	2	0.0869	0.0869	NUM
admet-258	241	3	0.2896	0.2896	NUM
admet-258	241	4	1.7246	1.7246	NUM
admet-258	241	5	compound	compound	NOUN
admet-258	241	6	c	c	NOUN
admet-258	241	7	3	3	NUM
admet-258	241	8	0.134	0.134	NUM
admet-258	241	9	0.028	0.028	NUM
admet-258	241	10	0.043	0.043	NUM
admet-258	241	11	0.046	0.046	NUM
admet-258	241	12	0.045	0.045	NUM
admet-258	241	13	pred	pre	VERB
admet-258	241	14	.	.	PUNCT
admet-258	242	1	vs.	vs.	X
admet-258	242	2	obs	obs	PROPN
admet-258	242	3	.	.	PUNCT
admet-258	243	1	0.2089	0.2089	NUM
admet-258	243	2	0.3208	0.3208	NUM
admet-258	243	3	0.3432	0.3432	NUM
admet-258	243	4	0.3358	0.3358	NUM
admet-258	243	5	compound	compound	NOUN
admet-258	243	6	d	d	NOUN
admet-258	243	7	3	3	NUM
admet-258	243	8	0.213	0.213	NUM
admet-258	243	9	0.053	0.053	NUM
admet-258	243	10	0.057	0.057	NUM
admet-258	243	11	0.124	0.124	NUM
admet-258	243	12	0.167	0.167	NUM
admet-258	243	13	0.204	0.204	NUM
admet-258	243	14	pred	pre	VERB
admet-258	243	15	.	.	PUNCT
admet-258	244	1	vs.	vs.	X
admet-258	244	2	obs	obs	PROPN
admet-258	244	3	0.2488	0.2488	NUM
admet-258	244	4	0.2676	0.2676	NUM
admet-258	244	5	0.5822	0.5822	NUM
admet-258	244	6	0.7840	0.7840	NUM
admet-258	244	7	0.9577	0.9577	NUM
admet-258	244	8	compound	compound	NOUN
admet-258	244	9	e	e	NOUN
admet-258	244	10	10	10	NUM
admet-258	244	11	2.211	2.211	NUM
admet-258	244	12	0.069	0.069	NUM
admet-258	244	13	0.071	0.071	NUM
admet-258	244	14	0.609	0.609	NUM
admet-258	244	15	1.502	1.502	NUM
admet-258	244	16	1.517	1.517	NUM
admet-258	244	17	pred	pre	VERB
admet-258	244	18	.	.	PUNCT
admet-258	245	1	vs.	vs.	X
admet-258	245	2	obs	obs	PROPN
admet-258	245	3	0.0312	0.0312	NUM
admet-258	245	4	0.0321	0.0321	NUM
admet-258	245	5	0.2754	0.2754	NUM
admet-258	245	6	0.6793	0.6793	NUM
admet-258	245	7	0.6861	0.6861	NUM
admet-258	245	8	compound	compound	NOUN
admet-258	245	9	f	f	NOUN
admet-258	245	10	10	10	NUM
admet-258	245	11	3.753	3.753	NUM
admet-258	245	12	2.743	2.743	NUM
admet-258	245	13	2.743	2.743	NUM
admet-258	245	14	2.742	2.742	NUM
admet-258	245	15	2.743	2.743	NUM
admet-258	245	16	2.308	2.308	NUM
admet-258	245	17	pred	pre	VERB
admet-258	245	18	.	.	PUNCT
admet-258	246	1	vs.	vs.	X
admet-258	246	2	obs	obs	PROPN
admet-258	246	3	0.7309	0.7309	NUM
admet-258	246	4	0.7309	0.7309	NUM
admet-258	246	5	0.7306	0.7306	NUM
admet-258	246	6	0.7309	0.7309	NUM
admet-258	246	7	0.6150	0.6150	NUM
admet-258	246	8	compound	compound	NOUN
admet-258	246	9	g	g	NOUN
admet-258	246	10	3	3	NUM
admet-258	246	11	0.020	0.020	NUM
admet-258	246	12	0.004	0.004	NUM
admet-258	246	13	0.030	0.030	NUM
admet-258	246	14	0.022	0.022	NUM
admet-258	246	15	0.074	0.074	NUM
admet-258	246	16	0.073	0.073	NUM
admet-258	246	17	pred	pre	VERB
admet-258	246	18	.	.	PUNCT
admet-258	247	1	vs.	vs.	X
admet-258	247	2	obs	obs	PROPN
admet-258	247	3	0.2000	0.2000	NUM
admet-258	247	4	1.500	1.500	NUM
admet-258	247	5	1.100	1.100	NUM
admet-258	247	6	3.700	3.700	NUM
admet-258	247	7	3.650	3.650	NUM
admet-258	247	8	compound	compound	NOUN
admet-258	247	9	h	h	NOUN
admet-258	247	10	3	3	NUM
admet-258	247	11	0.082	0.082	NUM
admet-258	247	12	0.0007	0.0007	NUM
admet-258	247	13	0.0007	0.0007	NUM
admet-258	247	14	0.031	0.031	NUM
admet-258	247	15	0.037	0.037	NUM
admet-258	247	16	0.071	0.071	NUM
admet-258	247	17	pred	pre	VERB
admet-258	247	18	.	.	PUNCT
admet-258	248	1	vs.	vs.	X
admet-258	248	2	obs	obs	PROPN
admet-258	248	3	0.0085	0.0085	NUM
admet-258	248	4	0.0085	0.0085	NUM
admet-258	248	5	0.3780	0.3780	NUM
admet-258	248	6	0.4512	0.4512	NUM
admet-258	248	7	0.8659	0.8659	NUM
admet-258	248	8	compound	compound	NOUN
admet-258	248	9	i	i	VERB
admet-258	248	10	3	3	NUM
admet-258	248	11	0.056	0.056	NUM
admet-258	248	12	0.011	0.011	NUM
admet-258	248	13	0.008	0.008	NUM
admet-258	248	14	0.020	0.020	NUM
admet-258	248	15	0.062	0.062	NUM
admet-258	248	16	pred	pre	VERB
admet-258	248	17	.	.	PUNCT
admet-258	249	1	vs.	vs.	ADP
admet-258	249	2	obs	obs	PROPN
admet-258	249	3	0.1964	0.1964	NUM
admet-258	249	4	0.1429	0.1429	NUM
admet-258	249	5	0.3571	0.3571	NUM
admet-258	249	6	1.107	1.107	NUM
admet-258	249	7	results	result	NOUN
admet-258	249	8	for	for	ADP
admet-258	249	9	the	the	DET
admet-258	249	10	lower	low	ADJ
admet-258	249	11	dose	dose	NOUN
admet-258	249	12	range	range	NOUN
admet-258	249	13	(	(	PUNCT
admet-258	249	14	see	see	VERB
admet-258	249	15	table	table	NOUN
admet-258	249	16	6	6	NUM
admet-258	249	17	,	,	PUNCT
admet-258	249	18	table	table	NOUN
admet-258	249	19	7	7	NUM
admet-258	249	20	and	and	CCONJ
admet-258	249	21	figure	figure	VERB
admet-258	249	22	4	4	NUM
admet-258	249	23	)	)	PUNCT
admet-258	249	24	support	support	VERB
admet-258	249	25	the	the	DET
admet-258	249	26	assumption	assumption	NOUN
admet-258	249	27	that	that	SCONJ
admet-258	249	28	the	the	DET
admet-258	249	29	buffer	buffer	NOUN
admet-258	249	30	solubility	solubility	NOUN
admet-258	249	31	typically	typically	ADV
admet-258	249	32	leads	lead	VERB
admet-258	249	33	to	to	ADP
admet-258	249	34	an	an	DET
admet-258	249	35	underprediction	underprediction	NOUN
admet-258	249	36	of	of	ADP
admet-258	249	37	both	both	DET
admet-258	249	38	cmax	cmax	NOUN
admet-258	249	39	and	and	CCONJ
admet-258	249	40	auc	auc	NOUN
admet-258	249	41	.	.	PUNCT
admet-258	250	1	the	the	DET
admet-258	250	2	only	only	ADJ
admet-258	250	3	exception	exception	NOUN
admet-258	250	4	is	be	AUX
admet-258	250	5	compound	compound	NOUN
admet-258	250	6	f	f	PROPN
admet-258	250	7	,	,	PUNCT
admet-258	250	8	despite	despite	SCONJ
admet-258	250	9	the	the	DET
admet-258	250	10	fact	fact	NOUN
admet-258	250	11	that	that	SCONJ
admet-258	250	12	its	its	PRON
admet-258	250	13	solubility	solubility	NOUN
admet-258	250	14	in	in	ADP
admet-258	250	15	rsif	rsif	NOUN
admet-258	250	16	is	be	AUX
admet-258	250	17	much	much	ADV
admet-258	250	18	higher	high	ADJ
admet-258	250	19	than	than	ADP
admet-258	250	20	in	in	ADP
admet-258	250	21	buffer	buffer	NOUN
admet-258	250	22	and	and	CCONJ
admet-258	250	23	fassif	fassif	NOUN
admet-258	250	24	-	-	PUNCT
admet-258	250	25	v2	v2	NOUN
admet-258	250	26	media	medium	NOUN
admet-258	250	27	.	.	PUNCT
admet-258	251	1	apparently	apparently	ADV
admet-258	251	2	,	,	PUNCT
admet-258	251	3	its	its	PRON
admet-258	251	4	rather	rather	ADV
admet-258	251	5	high	high	ADJ
admet-258	251	6	permeability	permeability	NOUN
admet-258	251	7	and	and	CCONJ
admet-258	251	8	sufficient	sufficient	ADJ
admet-258	251	9	solubility	solubility	NOUN
admet-258	251	10	lead	lead	VERB
admet-258	251	11	to	to	ADP
admet-258	251	12	nearly	nearly	ADV
admet-258	251	13	complete	complete	ADJ
admet-258	251	14	absorption	absorption	NOUN
admet-258	251	15	,	,	PUNCT
admet-258	251	16	yet	yet	CCONJ
admet-258	251	17	if	if	SCONJ
admet-258	251	18	the	the	DET
admet-258	251	19	lowest	low	ADJ
admet-258	251	20	measured	measure	VERB
admet-258	251	21	solubility	solubility	NOUN
admet-258	251	22	value	value	NOUN
admet-258	251	23	is	be	AUX
admet-258	251	24	used	use	VERB
admet-258	251	25	.	.	PUNCT
admet-258	252	1	even	even	ADV
admet-258	252	2	a	a	DET
admet-258	252	3	ten	ten	NUM
admet-258	252	4	times	time	NOUN
admet-258	252	5	higher	high	ADJ
admet-258	252	6	solubility	solubility	NOUN
admet-258	252	7	value	value	NOUN
admet-258	252	8	,	,	PUNCT
admet-258	252	9	according	accord	VERB
admet-258	252	10	to	to	ADP
admet-258	252	11	rsif	rsif	NOUN
admet-258	252	12	in	in	ADP
admet-258	252	13	vitro	vitro	X
admet-258	252	14	results	result	NOUN
admet-258	252	15	,	,	PUNCT
admet-258	252	16	does	do	AUX
admet-258	252	17	not	not	PART
admet-258	252	18	change	change	VERB
admet-258	252	19	the	the	DET
admet-258	252	20	predicted	predict	VERB
admet-258	252	21	concentration	concentration	NOUN
admet-258	252	22	-	-	PUNCT
admet-258	252	23	time	time	NOUN
admet-258	252	24	profile	profile	NOUN
admet-258	252	25	for	for	ADP
admet-258	252	26	this	this	DET
admet-258	252	27	compound	compound	NOUN
admet-258	252	28	for	for	ADP
admet-258	252	29	the	the	DET
admet-258	252	30	10	10	NUM
admet-258	252	31	mg	mg	PROPN
admet-258	252	32	/	/	SYM
admet-258	252	33	kg	kg	PROPN
admet-258	252	34	dose	dose	PROPN
admet-258	252	35	.	.	PUNCT
admet-258	253	1	admet	admet	PROPN
admet-258	253	2	&	&	CCONJ
admet-258	253	3	dmpk	dmpk	PROPN
admet-258	253	4	4(1	4(1	NOUN
admet-258	253	5	)	)	PUNCT
admet-258	253	6	(	(	PUNCT
admet-258	253	7	2016	2016	NUM
admet-258	253	8	)	)	PUNCT
admet-258	253	9	35	35	NUM
admet-258	253	10	-	-	SYM
admet-258	253	11	53	53	NUM
admet-258	253	12	simulated	simulate	VERB
admet-258	253	13	rat	rat	NOUN
admet-258	253	14	intestinal	intestinal	ADJ
admet-258	253	15	fluid	fluid	ADJ
admet-258	253	16	doi	doi	NOUN
admet-258	253	17	:	:	PUNCT
admet-258	253	18	10.5599	10.5599	NUM
admet-258	253	19	/	/	SYM
admet-258	253	20	admet.4.1.258	admet.4.1.258	PROPN
admet-258	253	21	47	47	NUM
admet-258	253	22	table	table	NOUN
admet-258	253	23	7	7	NUM
admet-258	253	24	.	.	PUNCT
admet-258	253	25	pbpk	pbpk	PROPN
admet-258	253	26	results	result	NOUN
admet-258	253	27	of	of	ADP
admet-258	253	28	auc	auc	NOUN
admet-258	253	29	(	(	PUNCT
admet-258	253	30	0	0	NUM
admet-258	253	31	-	-	PUNCT
admet-258	253	32	t	t	NOUN
admet-258	253	33	)	)	PUNCT
admet-258	253	34	in	in	ADP
admet-258	253	35	g	g	PROPN
admet-258	253	36	h	h	NOUN
admet-258	253	37	/	/	SYM
admet-258	253	38	ml	ml	X
admet-258	253	39	for	for	ADP
admet-258	253	40	lower	low	ADJ
admet-258	253	41	dose	dose	NOUN
admet-258	253	42	range	range	NOUN
admet-258	253	43	based	base	VERB
admet-258	253	44	on	on	ADP
admet-258	253	45	various	various	ADJ
admet-258	253	46	solubility	solubility	NOUN
admet-258	253	47	input	input	NOUN
admet-258	253	48	.	.	PUNCT
admet-258	254	1	auc	auc	NOUN
admet-258	254	2	buffer	buffer	NOUN
admet-258	254	3	,	,	PUNCT
admet-258	254	4	fassif	fassif	VERB
admet-258	254	5	,	,	PUNCT
admet-258	254	6	fassif	fassif	VERB
admet-258	254	7	with	with	ADP
admet-258	254	8	theoretical	theoretical	ADJ
admet-258	254	9	bile	bile	NOUN
admet-258	254	10	salt	salt	NOUN
admet-258	254	11	correction	correction	NOUN
admet-258	254	12	(	(	PUNCT
admet-258	254	13	auc	auc	X
admet-258	254	14	fassif	fassif	NOUN
admet-258	254	15	bile	bile	NOUN
admet-258	254	16	)	)	PUNCT
admet-258	254	17	and	and	CCONJ
admet-258	254	18	rsif	rsif	NOUN
admet-258	254	19	refer	refer	VERB
admet-258	254	20	to	to	ADP
admet-258	254	21	equilibrium	equilibrium	NOUN
admet-258	254	22	values	value	NOUN
admet-258	254	23	,	,	PUNCT
admet-258	254	24	whereas	whereas	SCONJ
admet-258	254	25	gi	gi	NOUN
admet-258	254	26	disso	disso	PROPN
admet-258	254	27	comprises	comprise	VERB
admet-258	254	28	the	the	DET
admet-258	254	29	input	input	NOUN
admet-258	254	30	of	of	ADP
admet-258	254	31	the	the	DET
admet-258	254	32	full	full	ADJ
admet-258	254	33	gi	gi	NOUN
admet-258	254	34	dissolution	dissolution	NOUN
admet-258	254	35	profile	profile	NOUN
admet-258	254	36	.	.	PUNCT
admet-258	255	1	pred	pre	VERB
admet-258	255	2	.	.	PUNCT
admet-258	256	1	vs.	vs.	X
admet-258	256	2	obs	obs	PROPN
admet-258	256	3	.	.	PUNCT
admet-258	257	1	denotes	denote	VERB
admet-258	257	2	the	the	DET
admet-258	257	3	ratio	ratio	NOUN
admet-258	257	4	of	of	ADP
admet-258	257	5	the	the	DET
admet-258	257	6	predicted	predict	VERB
admet-258	257	7	values	value	NOUN
admet-258	257	8	vs.	vs.	ADP
admet-258	257	9	the	the	DET
admet-258	257	10	observed	observe	VERB
admet-258	257	11	auc	auc	NOUN
admet-258	257	12	.	.	PUNCT
admet-258	258	1	dose	dose	NOUN
admet-258	258	2	,	,	PUNCT
admet-258	258	3	mg	mg	PROPN
admet-258	258	4	/	/	SYM
admet-258	258	5	kg	kg	PROPN
admet-258	258	6	auc	auc	X
admet-258	258	7	obs	obs	NOUN
admet-258	258	8	auc	auc	NOUN
admet-258	258	9	buffer	buffer	NOUN
admet-258	258	10	auc	auc	NOUN
admet-258	258	11	fassif	fassif	NOUN
admet-258	258	12	auc	auc	X
admet-258	258	13	fassif	fassif	NOUN
admet-258	258	14	bile	bile	NOUN
admet-258	258	15	auc	auc	NOUN
admet-258	258	16	rsif	rsif	NOUN
admet-258	258	17	auc	auc	X
admet-258	258	18	gi	gi	X
admet-258	258	19	disso	disso	PROPN
admet-258	258	20	compound	compound	VERB
admet-258	258	21	a	a	PRON
admet-258	258	22	10	10	NUM
admet-258	258	23	16.51	16.51	NUM
admet-258	258	24	0.186	0.186	NUM
admet-258	258	25	1.08	1.08	NUM
admet-258	258	26	0.407	0.407	NUM
admet-258	258	27	5.05	5.05	NUM
admet-258	258	28	pred	pre	VERB
admet-258	258	29	.	.	PUNCT
admet-258	259	1	vs.	vs.	X
admet-258	259	2	obs	obs	PROPN
admet-258	259	3	0.0113	0.0113	NUM
admet-258	259	4	0.0654	0.0654	NUM
admet-258	259	5	0.0247	0.0247	NUM
admet-258	259	6	0.3059	0.3059	NUM
admet-258	259	7	compound	compound	NOUN
admet-258	259	8	b	b	NOUN
admet-258	259	9	3	3	NUM
admet-258	259	10	1.928	1.928	NUM
admet-258	259	11	0.146	0.146	NUM
admet-258	259	12	0.146	0.146	NUM
admet-258	259	13	0.414	0.414	NUM
admet-258	259	14	1.867	1.867	NUM
admet-258	259	15	pred	pre	VERB
admet-258	259	16	.	.	PUNCT
admet-258	260	1	vs.	vs.	ADP
admet-258	260	2	obs	obs	PROPN
admet-258	261	1	0.0757	0.0757	NUM
admet-258	261	2	0.0757	0.0757	NUM
admet-258	261	3	0.2147	0.2147	NUM
admet-258	261	4	0.9684	0.9684	NUM
admet-258	261	5	compound	compound	NOUN
admet-258	261	6	c	c	NOUN
admet-258	261	7	3	3	NUM
admet-258	261	8	0.232	0.232	NUM
admet-258	261	9	0.064	0.064	NUM
admet-258	261	10	0.069	0.069	NUM
admet-258	261	11	0.070	0.070	NUM
admet-258	261	12	0.071	0.071	NUM
admet-258	261	13	pred	pre	VERB
admet-258	261	14	.	.	PUNCT
admet-258	262	1	vs.	vs.	ADP
admet-258	262	2	obs	obs	PROPN
admet-258	263	1	0.2759	0.2759	NUM
admet-258	263	2	0.2974	0.2974	NUM
admet-258	263	3	0.3017	0.3017	NUM
admet-258	263	4	0.3060	0.3060	NUM
admet-258	263	5	compound	compound	NOUN
admet-258	263	6	d	d	NOUN
admet-258	263	7	3	3	NUM
admet-258	263	8	2.631	2.631	NUM
admet-258	263	9	0.570	0.570	NUM
admet-258	263	10	0.607	0.607	NUM
admet-258	263	11	1.154	1.154	NUM
admet-258	263	12	1.570	1.570	NUM
admet-258	263	13	1.802	1.802	NUM
admet-258	263	14	pred	pre	VERB
admet-258	263	15	.	.	PUNCT
admet-258	264	1	vs.	vs.	X
admet-258	264	2	obs	obs	PROPN
admet-258	264	3	0.2166	0.2166	NUM
admet-258	264	4	0.2307	0.2307	NUM
admet-258	264	5	0.4386	0.4386	NUM
admet-258	264	6	0.5967	0.5967	NUM
admet-258	264	7	0.6849	0.6849	NUM
admet-258	264	8	compound	compound	NOUN
admet-258	264	9	e	e	NOUN
admet-258	264	10	10	10	NUM
admet-258	264	11	26.4	26.4	NUM
admet-258	264	12	0.758	0.758	NUM
admet-258	264	13	0.795	0.795	NUM
admet-258	264	14	4.803	4.803	NUM
admet-258	264	15	9.351	9.351	NUM
admet-258	264	16	9.335	9.335	NUM
admet-258	264	17	pred	pre	VERB
admet-258	264	18	.	.	PUNCT
admet-258	265	1	vs.	vs.	X
admet-258	265	2	obs	obs	PROPN
admet-258	265	3	0.0287	0.0287	NUM
admet-258	266	1	0.0301	0.0301	NUM
admet-258	266	2	0.1819	0.1819	NUM
admet-258	266	3	0.3542	0.3542	NUM
admet-258	266	4	0.3536	0.3536	NUM
admet-258	266	5	compound	compound	NOUN
admet-258	266	6	f	f	NOUN
admet-258	266	7	10	10	NUM
admet-258	266	8	13.4	13.4	NUM
admet-258	266	9	7.812	7.812	NUM
admet-258	266	10	7.812	7.812	NUM
admet-258	266	11	7.823	7.823	NUM
admet-258	266	12	7.812	7.812	NUM
admet-258	266	13	7.734	7.734	NUM
admet-258	266	14	pred	pre	VERB
admet-258	266	15	.	.	PUNCT
admet-258	267	1	vs.	vs.	X
admet-258	267	2	obs	obs	PROPN
admet-258	268	1	0.5830	0.5830	NUM
admet-258	268	2	0.5830	0.5830	NUM
admet-258	268	3	0.5838	0.5838	NUM
admet-258	268	4	0.5830	0.5830	NUM
admet-258	268	5	0.5772	0.5772	NUM
admet-258	268	6	compound	compound	NOUN
admet-258	268	7	g	g	NOUN
admet-258	268	8	3	3	NUM
admet-258	268	9	0.131	0.131	NUM
admet-258	268	10	0.020	0.020	NUM
admet-258	268	11	0.116	0.116	NUM
admet-258	268	12	0.090	0.090	NUM
admet-258	268	13	0.285	0.285	NUM
admet-258	268	14	0.260	0.260	NUM
admet-258	268	15	pred	pre	VERB
admet-258	268	16	.	.	PUNCT
admet-258	269	1	vs.	vs.	ADP
admet-258	269	2	obs	obs	PROPN
admet-258	269	3	0.1527	0.1527	NUM
admet-258	269	4	0.8855	0.8855	NUM
admet-258	269	5	0.6870	0.6870	NUM
admet-258	269	6	2.176	2.176	NUM
admet-258	269	7	1.985	1.985	NUM
admet-258	269	8	compound	compound	NOUN
admet-258	269	9	h	h	NOUN
admet-258	269	10	3	3	NUM
admet-258	269	11	1.06	1.06	NUM
admet-258	269	12	0.007	0.007	NUM
admet-258	269	13	0.007	0.007	NUM
admet-258	269	14	0.228	0.228	NUM
admet-258	269	15	0.312	0.312	NUM
admet-258	269	16	0.546	0.546	NUM
admet-258	269	17	pred	pre	VERB
admet-258	269	18	.	.	PUNCT
admet-258	270	1	vs.	vs.	X
admet-258	270	2	obs	obs	PROPN
admet-258	270	3	0.0066	0.0066	NUM
admet-258	270	4	0.0066	0.0066	NUM
admet-258	270	5	0.2151	0.2151	NUM
admet-258	270	6	0.2943	0.2943	NUM
admet-258	270	7	0.5151	0.5151	NUM
admet-258	270	8	compound	compound	NOUN
admet-258	270	9	i	i	VERB
admet-258	270	10	3	3	NUM
admet-258	270	11	0.571	0.571	NUM
admet-258	270	12	0.038	0.038	NUM
admet-258	270	13	0.033	0.033	NUM
admet-258	270	14	0.062	0.062	NUM
admet-258	270	15	0.19	0.19	NUM
admet-258	270	16	pred	pre	VERB
admet-258	270	17	.	.	PUNCT
admet-258	271	1	vs.	vs.	X
admet-258	271	2	obs	obs	PROPN
admet-258	271	3	0.0665	0.0665	NUM
admet-258	271	4	0.0578	0.0578	NUM
admet-258	271	5	0.1086	0.1086	NUM
admet-258	271	6	0.3327	0.3327	NUM
admet-258	271	7	when	when	SCONJ
admet-258	271	8	the	the	DET
admet-258	271	9	in	in	ADP
admet-258	271	10	vitro	vitro	X
admet-258	271	11	equilibrium	equilibrium	NOUN
admet-258	271	12	solubility	solubility	NOUN
admet-258	271	13	in	in	ADP
admet-258	271	14	fassif	fassif	NOUN
admet-258	271	15	is	be	AUX
admet-258	271	16	used	use	VERB
admet-258	271	17	to	to	PART
admet-258	271	18	correct	correct	VERB
admet-258	271	19	the	the	DET
admet-258	271	20	bile	bile	NOUN
admet-258	271	21	salt	salt	NOUN
admet-258	271	22	dependent	dependent	ADJ
admet-258	271	23	solubility	solubility	NOUN
admet-258	271	24	,	,	PUNCT
admet-258	271	25	an	an	DET
admet-258	271	26	improved	improved	ADJ
admet-258	271	27	prediction	prediction	NOUN
admet-258	271	28	is	be	AUX
admet-258	271	29	found	find	VERB
admet-258	271	30	in	in	ADP
admet-258	271	31	a	a	DET
admet-258	271	32	number	number	NOUN
admet-258	271	33	of	of	ADP
admet-258	271	34	cases	case	NOUN
admet-258	271	35	.	.	PUNCT
admet-258	272	1	in	in	ADP
admet-258	272	2	order	order	NOUN
admet-258	272	3	to	to	PART
admet-258	272	4	allow	allow	VERB
admet-258	272	5	for	for	ADP
admet-258	272	6	an	an	DET
admet-258	272	7	estimate	estimate	NOUN
admet-258	272	8	of	of	ADP
admet-258	272	9	bile	bile	NOUN
admet-258	272	10	salt	salt	NOUN
admet-258	272	11	dependent	dependent	ADJ
admet-258	272	12	solubility	solubility	NOUN
admet-258	272	13	in	in	ADP
admet-258	272	14	case	case	NOUN
admet-258	272	15	fassif	fassif	VERB
admet-258	272	16	solubility	solubility	NOUN
admet-258	272	17	data	datum	NOUN
admet-258	272	18	is	be	AUX
admet-258	272	19	not	not	PART
admet-258	272	20	available	available	ADJ
admet-258	272	21	,	,	PUNCT
admet-258	272	22	the	the	DET
admet-258	272	23	use	use	NOUN
admet-258	272	24	of	of	ADP
admet-258	272	25	the	the	DET
admet-258	272	26	theoretical	theoretical	ADJ
admet-258	272	27	bile	bile	NOUN
admet-258	272	28	solubilization	solubilization	NOUN
admet-258	272	29	ratio	ratio	NOUN
admet-258	272	30	may	may	AUX
admet-258	272	31	be	be	AUX
admet-258	272	32	an	an	DET
admet-258	272	33	option	option	NOUN
admet-258	272	34	.	.	PUNCT
admet-258	273	1	as	as	SCONJ
admet-258	273	2	shown	show	VERB
admet-258	273	3	in	in	ADP
admet-258	273	4	table	table	NOUN
admet-258	273	5	4	4	NUM
admet-258	273	6	the	the	DET
admet-258	273	7	results	result	NOUN
admet-258	273	8	of	of	ADP
admet-258	273	9	this	this	DET
admet-258	273	10	method	method	NOUN
admet-258	273	11	might	might	AUX
admet-258	273	12	significantly	significantly	ADV
admet-258	273	13	deviate	deviate	VERB
admet-258	273	14	from	from	ADP
admet-258	273	15	the	the	DET
admet-258	273	16	measured	measure	VERB
admet-258	273	17	values	value	NOUN
admet-258	273	18	.	.	PUNCT
admet-258	274	1	as	as	SCONJ
admet-258	274	2	the	the	DET
admet-258	274	3	results	result	NOUN
admet-258	274	4	in	in	ADP
admet-258	274	5	table	table	NOUN
admet-258	274	6	6	6	NUM
admet-258	274	7	and	and	CCONJ
admet-258	274	8	table	table	NOUN
admet-258	274	9	7	7	NUM
admet-258	274	10	suggest	suggest	VERB
admet-258	274	11	,	,	PUNCT
admet-258	274	12	for	for	ADP
admet-258	274	13	most	most	ADJ
admet-258	274	14	of	of	ADP
admet-258	274	15	the	the	DET
admet-258	274	16	investigated	investigate	VERB
admet-258	274	17	compounds	compound	NOUN
admet-258	274	18	the	the	DET
admet-258	274	19	use	use	NOUN
admet-258	274	20	of	of	ADP
admet-258	274	21	the	the	DET
admet-258	274	22	theoretical	theoretical	ADJ
admet-258	274	23	bile	bile	NOUN
admet-258	274	24	salt	salt	NOUN
admet-258	274	25	ratio	ratio	NOUN
admet-258	274	26	leads	lead	VERB
admet-258	274	27	to	to	ADP
admet-258	274	28	an	an	DET
admet-258	274	29	improved	improved	ADJ
admet-258	274	30	prediction	prediction	NOUN
admet-258	274	31	,	,	PUNCT
admet-258	274	32	but	but	CCONJ
admet-258	274	33	underprediction	underprediction	NOUN
admet-258	274	34	for	for	ADP
admet-258	274	35	low	low	ADJ
admet-258	274	36	solubility	solubility	NOUN
admet-258	274	37	compounds	compound	NOUN
admet-258	274	38	can	can	AUX
admet-258	274	39	still	still	ADV
admet-258	274	40	be	be	AUX
admet-258	274	41	significant	significant	ADJ
admet-258	274	42	.	.	PUNCT
admet-258	275	1	when	when	SCONJ
admet-258	275	2	comparing	compare	VERB
admet-258	275	3	the	the	DET
admet-258	275	4	simulation	simulation	NOUN
admet-258	275	5	results	result	NOUN
admet-258	275	6	that	that	PRON
admet-258	275	7	were	be	AUX
admet-258	275	8	generated	generate	VERB
admet-258	275	9	using	use	VERB
admet-258	275	10	the	the	DET
admet-258	275	11	in	in	ADV
admet-258	275	12	vitro	vitro	X
admet-258	275	13	rat	rat	X
admet-258	275	14	sif	sif	PROPN
admet-258	275	15	solubility	solubility	PROPN
admet-258	275	16	,	,	PUNCT
admet-258	275	17	for	for	ADP
admet-258	275	18	nearly	nearly	ADV
admet-258	275	19	all	all	PRON
admet-258	275	20	compounds	compound	NOUN
admet-258	275	21	of	of	ADP
admet-258	275	22	the	the	DET
admet-258	275	23	current	current	ADJ
admet-258	275	24	test	test	NOUN
admet-258	275	25	set	set	VERB
admet-258	275	26	an	an	DET
admet-258	275	27	improved	improved	ADJ
admet-258	275	28	prediction	prediction	NOUN
admet-258	275	29	result	result	NOUN
admet-258	275	30	is	be	AUX
admet-258	275	31	achieved	achieve	VERB
admet-258	275	32	.	.	PUNCT
admet-258	276	1	this	this	PRON
admet-258	276	2	is	be	AUX
admet-258	276	3	reflected	reflect	VERB
admet-258	276	4	in	in	ADP
admet-258	276	5	a	a	DET
admet-258	276	6	maximum	maximum	ADJ
admet-258	276	7	deviation	deviation	NOUN
admet-258	276	8	of	of	ADP
admet-258	276	9	the	the	DET
admet-258	276	10	predicted	predict	VERB
admet-258	276	11	value	value	NOUN
admet-258	276	12	vs	vs	ADP
admet-258	276	13	the	the	DET
admet-258	276	14	observed	observe	VERB
admet-258	276	15	value	value	NOUN
admet-258	276	16	by	by	ADP
admet-258	276	17	a	a	DET
admet-258	276	18	factor	factor	NOUN
admet-258	276	19	of	of	ADP
admet-258	276	20	at	at	ADV
admet-258	276	21	least	least	ADJ
admet-258	276	22	3	3	NUM
admet-258	276	23	.	.	X
admet-258	277	1	for	for	ADP
admet-258	277	2	some	some	DET
admet-258	277	3	compounds	compound	NOUN
admet-258	277	4	even	even	ADV
admet-258	277	5	the	the	DET
admet-258	277	6	range	range	NOUN
admet-258	277	7	of	of	ADP
admet-258	277	8	2	2	NUM
admet-258	277	9	-	-	ADJ
admet-258	277	10	fold	fold	ADJ
admet-258	277	11	variation	variation	NOUN
admet-258	277	12	is	be	AUX
admet-258	277	13	reached	reach	VERB
admet-258	277	14	.	.	PUNCT
admet-258	278	1	overprediction	overprediction	NOUN
admet-258	278	2	was	be	AUX
admet-258	278	3	observed	observe	VERB
admet-258	278	4	only	only	ADV
admet-258	278	5	in	in	ADP
admet-258	278	6	one	one	NUM
admet-258	278	7	case	case	NOUN
admet-258	278	8	(	(	PUNCT
admet-258	278	9	compound	compound	NOUN
admet-258	278	10	g	g	NOUN
admet-258	278	11	)	)	PUNCT
admet-258	278	12	,	,	PUNCT
admet-258	278	13	for	for	ADP
admet-258	278	14	which	which	PRON
admet-258	278	15	even	even	ADV
admet-258	278	16	fassif	fassif	NOUN
admet-258	278	17	-	-	PUNCT
admet-258	278	18	v2	v2	NOUN
admet-258	278	19	solubility	solubility	NOUN
admet-258	278	20	resulted	result	VERB
admet-258	278	21	in	in	ADP
admet-258	278	22	a	a	DET
admet-258	278	23	too	too	ADV
admet-258	278	24	high	high	ADJ
admet-258	278	25	value	value	NOUN
admet-258	278	26	of	of	ADP
admet-258	278	27	cmax	cmax	NOUN
admet-258	278	28	.	.	PUNCT
admet-258	279	1	in	in	ADP
admet-258	279	2	case	case	NOUN
admet-258	279	3	of	of	ADP
admet-258	279	4	compound	compound	NOUN
admet-258	279	5	d	d	PROPN
admet-258	279	6	and	and	CCONJ
admet-258	279	7	h	h	NOUN
admet-258	279	8	,	,	PUNCT
admet-258	279	9	the	the	DET
admet-258	279	10	full	full	ADJ
admet-258	279	11	gi	gi	NOUN
admet-258	279	12	dissolution	dissolution	NOUN
admet-258	279	13	further	far	ADV
admet-258	279	14	improves	improve	VERB
admet-258	279	15	the	the	DET
admet-258	279	16	simulation	simulation	NOUN
admet-258	279	17	outcome	outcome	NOUN
admet-258	279	18	.	.	PUNCT
admet-258	280	1	however	however	ADV
admet-258	280	2	,	,	PUNCT
admet-258	280	3	taking	take	VERB
admet-258	280	4	into	into	ADP
admet-258	280	5	account	account	NOUN
admet-258	280	6	the	the	DET
admet-258	280	7	time	time	NOUN
admet-258	280	8	and	and	CCONJ
admet-258	280	9	effort	effort	NOUN
admet-258	280	10	to	to	PART
admet-258	280	11	record	record	VERB
admet-258	280	12	the	the	DET
admet-258	280	13	dissolution	dissolution	NOUN
admet-258	280	14	profile	profile	NOUN
admet-258	280	15	,	,	PUNCT
admet-258	280	16	it	it	PRON
admet-258	280	17	appears	appear	VERB
admet-258	280	18	justified	justified	ADJ
admet-258	280	19	to	to	PART
admet-258	280	20	use	use	VERB
admet-258	280	21	rsif	rsif	NOUN
admet-258	280	22	equilibrium	equilibrium	NOUN
admet-258	280	23	solubility	solubility	NOUN
admet-258	280	24	instead	instead	ADV
admet-258	280	25	.	.	PUNCT
admet-258	281	1	berghausen	berghausen	PROPN
admet-258	281	2	et	et	PROPN
admet-258	281	3	al	al	PROPN
admet-258	281	4	.	.	PROPN
admet-258	281	5	admet	admet	PROPN
admet-258	281	6	&	&	CCONJ
admet-258	281	7	dmpk	dmpk	PROPN
admet-258	281	8	4(1	4(1	NOUN
admet-258	281	9	)	)	PUNCT
admet-258	281	10	(	(	PUNCT
admet-258	281	11	2016	2016	NUM
admet-258	281	12	)	)	PUNCT
admet-258	281	13	35	35	NUM
admet-258	281	14	-	-	SYM
admet-258	281	15	53	53	NUM
admet-258	281	16	48	48	NUM
admet-258	281	17	-2.5	-2.5	NOUN
admet-258	282	1	-2	-2	NOUN
admet-258	283	1	-1.5	-1.5	NUM
admet-258	283	2	-1	-1	PROPN
admet-258	283	3	-0.5	-0.5	X
admet-258	283	4	0	0	NUM
admet-258	283	5	0.5	0.5	NUM
admet-258	283	6	1	1	NUM
admet-258	283	7	lo	lo	NOUN
admet-258	283	8	g	g	NOUN
admet-258	283	9	(	(	PUNCT
admet-258	283	10	p	p	X
admet-258	283	11	re	re	PROPN
admet-258	283	12	d	d	NOUN
admet-258	283	13	ic	ic	X
admet-258	283	14	te	te	PROPN
admet-258	283	15	d	d	PROPN
admet-258	283	16	v	v	PROPN
admet-258	283	17	s	s	NOUN
admet-258	283	18	.	.	PUNCT
admet-258	284	1	o	o	X
admet-258	284	2	b	b	X
admet-258	284	3	s	s	PROPN
admet-258	284	4	e	e	X
admet-258	284	5	rv	rv	X
admet-258	284	6	e	e	PROPN
admet-258	284	7	d	d	PROPN
admet-258	284	8	)	)	PUNCT
admet-258	284	9	cmax	cmax	NOUN
admet-258	284	10	buffer	buffer	NOUN
admet-258	284	11	cmax	cmax	NOUN
admet-258	284	12	fassif	fassif	NOUN
admet-258	284	13	cmax	cmax	NOUN
admet-258	284	14	fassif	fassif	VERB
admet-258	284	15	bile	bile	NOUN
admet-258	284	16	cmax	cmax	NOUN
admet-258	284	17	rat	rat	NOUN
admet-258	284	18	fluid	fluid	ADJ
admet-258	284	19	cmax	cmax	NOUN
admet-258	284	20	gi	gi	X
admet-258	284	21	disso	disso	PROPN
admet-258	284	22	cpd	cpd	PROPN
admet-258	284	23	a	a	DET
admet-258	284	24	cpd	cpd	PROPN
admet-258	284	25	b	b	PROPN
admet-258	284	26	cpd	cpd	PROPN
admet-258	284	27	c	c	PROPN
admet-258	284	28	cpd	cpd	PROPN
admet-258	284	29	d	d	PROPN
admet-258	284	30	cpd	cpd	PROPN
admet-258	284	31	e	e	PROPN
admet-258	284	32	cpd	cpd	PROPN
admet-258	284	33	f	f	PROPN
admet-258	284	34	cpd	cpd	PROPN
admet-258	284	35	g	g	PROPN
admet-258	284	36	cpd	cpd	PROPN
admet-258	284	37	h	h	PROPN
admet-258	284	38	cpd	cpd	PROPN
admet-258	285	1	i	i	PRON
admet-258	285	2	-2.5	-2.5	VERB
admet-258	285	3	-2	-2	INTJ
admet-258	285	4	-1.5	-1.5	NUM
admet-258	285	5	-1	-1	PROPN
admet-258	285	6	-0.5	-0.5	X
admet-258	285	7	0	0	NUM
admet-258	285	8	0.5	0.5	NUM
admet-258	285	9	lo	lo	PROPN
admet-258	285	10	g	g	PROPN
admet-258	285	11	(	(	PUNCT
admet-258	285	12	p	p	X
admet-258	285	13	re	re	PROPN
admet-258	285	14	d	d	NOUN
admet-258	285	15	ic	ic	X
admet-258	285	16	te	te	PROPN
admet-258	285	17	d	d	PROPN
admet-258	285	18	v	v	PROPN
admet-258	285	19	s	s	NOUN
admet-258	285	20	.	.	PUNCT
admet-258	286	1	o	o	X
admet-258	287	1	b	b	X
admet-258	287	2	s	s	PROPN
admet-258	287	3	e	e	X
admet-258	287	4	rv	rv	X
admet-258	287	5	e	e	PROPN
admet-258	287	6	d	d	PROPN
admet-258	287	7	)	)	PUNCT
admet-258	287	8	auc	auc	NOUN
admet-258	287	9	buffer	buffer	NOUN
admet-258	287	10	auc	auc	NOUN
admet-258	287	11	fassif	fassif	NOUN
admet-258	287	12	auc	auc	X
admet-258	287	13	fassif	fassif	NOUN
admet-258	287	14	bile	bile	NOUN
admet-258	287	15	auc	auc	NOUN
admet-258	287	16	rat	rat	NOUN
admet-258	287	17	fluid	fluid	ADJ
admet-258	287	18	auc	auc	NOUN
admet-258	287	19	gi	gi	X
admet-258	287	20	disso	disso	PROPN
admet-258	287	21	cpd	cpd	PROPN
admet-258	287	22	a	a	DET
admet-258	287	23	cpd	cpd	PROPN
admet-258	287	24	b	b	PROPN
admet-258	287	25	cpd	cpd	PROPN
admet-258	287	26	c	c	PROPN
admet-258	287	27	cpd	cpd	PROPN
admet-258	287	28	d	d	PROPN
admet-258	287	29	cpd	cpd	PROPN
admet-258	287	30	e	e	PROPN
admet-258	287	31	cpd	cpd	PROPN
admet-258	287	32	f	f	PROPN
admet-258	287	33	cpd	cpd	PROPN
admet-258	287	34	g	g	PROPN
admet-258	287	35	cpd	cpd	PROPN
admet-258	287	36	h	h	PROPN
admet-258	287	37	cpd	cpd	PROPN
admet-258	288	1	i	i	PRON
admet-258	288	2	figure	figure	VERB
admet-258	288	3	4	4	NUM
admet-258	288	4	.	.	PUNCT
admet-258	288	5	a	a	DET
admet-258	288	6	)	)	PUNCT
admet-258	288	7	cmax	cmax	NOUN
admet-258	288	8	and	and	CCONJ
admet-258	288	9	b	b	X
admet-258	288	10	)	)	PUNCT
admet-258	288	11	auc	auc	NOUN
admet-258	288	12	from	from	ADP
admet-258	288	13	simulations	simulation	NOUN
admet-258	288	14	performed	perform	VERB
admet-258	288	15	on	on	ADP
admet-258	288	16	studies	study	NOUN
admet-258	288	17	comprising	comprise	VERB
admet-258	288	18	doses	dose	NOUN
admet-258	288	19	from	from	ADP
admet-258	288	20	a	a	DET
admet-258	288	21	3	3	NUM
admet-258	288	22	to	to	PART
admet-258	288	23	10	10	NUM
admet-258	288	24	mg	mg	NUM
admet-258	288	25	/	/	SYM
admet-258	288	26	kg	kg	PROPN
admet-258	288	27	dose	dose	NOUN
admet-258	288	28	observations	observation	NOUN
admet-258	288	29	at	at	ADP
admet-258	288	30	higher	high	ADJ
admet-258	288	31	p.o	p.o	PROPN
admet-258	288	32	.	.	PROPN
admet-258	288	33	doses	dose	NOUN
admet-258	288	34	compared	compare	VERB
admet-258	288	35	to	to	ADP
admet-258	288	36	low	low	PROPN
admet-258	288	37	p.o	p.o	PROPN
admet-258	288	38	.	.	PROPN
admet-258	288	39	doses	dose	NOUN
admet-258	288	40	,	,	PUNCT
admet-258	288	41	the	the	DET
admet-258	288	42	solubility	solubility	NOUN
admet-258	288	43	and	and	CCONJ
admet-258	288	44	dissolution	dissolution	NOUN
admet-258	288	45	properties	property	NOUN
admet-258	288	46	of	of	ADP
admet-258	288	47	a	a	DET
admet-258	288	48	compound	compound	NOUN
admet-258	288	49	are	be	AUX
admet-258	288	50	assumed	assume	VERB
admet-258	288	51	to	to	PART
admet-258	288	52	impact	impact	VERB
admet-258	288	53	the	the	DET
admet-258	288	54	overall	overall	ADJ
admet-258	288	55	pk	pk	NOUN
admet-258	288	56	profile	profile	NOUN
admet-258	288	57	in	in	ADP
admet-258	288	58	an	an	DET
admet-258	288	59	even	even	ADV
admet-258	288	60	stronger	strong	ADJ
admet-258	288	61	way	way	NOUN
admet-258	288	62	when	when	SCONJ
admet-258	288	63	higher	high	ADJ
admet-258	288	64	doses	dose	NOUN
admet-258	288	65	area	area	NOUN
admet-258	288	66	applied	apply	VERB
admet-258	288	67	.	.	PUNCT
admet-258	289	1	pbpk	pbpk	NOUN
admet-258	289	2	results	result	NOUN
admet-258	289	3	for	for	ADP
admet-258	289	4	doses	dose	NOUN
admet-258	289	5	from	from	ADP
admet-258	289	6	30	30	NUM
admet-258	289	7	to	to	PART
admet-258	289	8	300	300	NUM
admet-258	289	9	mg	mg	NOUN
admet-258	289	10	/	/	SYM
admet-258	289	11	kg	kg	PROPN
admet-258	289	12	are	be	AUX
admet-258	289	13	summarized	summarize	VERB
admet-258	289	14	in	in	ADP
admet-258	289	15	table	table	NOUN
admet-258	289	16	8	8	NUM
admet-258	289	17	and	and	CCONJ
admet-258	289	18	table	table	NOUN
admet-258	289	19	9	9	NUM
admet-258	289	20	.	.	PUNCT
admet-258	290	1	figure	figure	NOUN
admet-258	290	2	5	5	NUM
admet-258	290	3	displays	display	VERB
admet-258	290	4	the	the	DET
admet-258	290	5	results	result	NOUN
admet-258	290	6	as	as	ADP
admet-258	290	7	ratio	ratio	NOUN
admet-258	290	8	of	of	ADP
admet-258	290	9	predicted	predict	VERB
admet-258	290	10	vs.	vs.	ADP
admet-258	290	11	observed	observe	VERB
admet-258	290	12	for	for	ADP
admet-258	290	13	both	both	DET
admet-258	290	14	cmax	cmax	NOUN
admet-258	290	15	and	and	CCONJ
admet-258	290	16	auc	auc	NOUN
admet-258	290	17	.	.	PUNCT
admet-258	291	1	based	base	VERB
admet-258	291	2	on	on	ADP
admet-258	291	3	rsif	rsif	NOUN
admet-258	291	4	solubility	solubility	PROPN
admet-258	291	5	,	,	PUNCT
admet-258	291	6	predicted	predict	VERB
admet-258	291	7	cmax	cmax	NOUN
admet-258	291	8	a	a	DET
admet-258	291	9	)	)	PUNCT
admet-258	291	10	b	b	NOUN
admet-258	291	11	)	)	PUNCT
admet-258	291	12	admet	admet	PROPN
admet-258	291	13	&	&	CCONJ
admet-258	291	14	dmpk	dmpk	PROPN
admet-258	291	15	4(1	4(1	NOUN
admet-258	291	16	)	)	PUNCT
admet-258	291	17	(	(	PUNCT
admet-258	291	18	2016	2016	NUM
admet-258	291	19	)	)	PUNCT
admet-258	291	20	35	35	NUM
admet-258	291	21	-	-	SYM
admet-258	291	22	53	53	NUM
admet-258	291	23	simulated	simulate	VERB
admet-258	291	24	rat	rat	NOUN
admet-258	291	25	intestinal	intestinal	ADJ
admet-258	291	26	fluid	fluid	ADJ
admet-258	291	27	doi	doi	NOUN
admet-258	291	28	:	:	PUNCT
admet-258	291	29	10.5599	10.5599	NUM
admet-258	291	30	/	/	SYM
admet-258	291	31	admet.4.1.258	admet.4.1.258	NOUN
admet-258	291	32	49	49	NUM
admet-258	291	33	of	of	ADP
admet-258	291	34	all	all	DET
admet-258	291	35	compounds	compound	NOUN
admet-258	291	36	tested	test	VERB
admet-258	291	37	is	be	AUX
admet-258	291	38	found	find	VERB
admet-258	291	39	within	within	ADP
admet-258	291	40	a	a	DET
admet-258	291	41	3	3	NUM
admet-258	291	42	-	-	ADJ
admet-258	291	43	fold	fold	ADJ
admet-258	291	44	range	range	NOUN
admet-258	291	45	as	as	SCONJ
admet-258	291	46	compared	compare	VERB
admet-258	291	47	to	to	ADP
admet-258	291	48	observed	observed	ADJ
admet-258	291	49	values	value	NOUN
admet-258	291	50	,	,	PUNCT
admet-258	291	51	most	most	ADJ
admet-258	291	52	of	of	ADP
admet-258	291	53	them	they	PRON
admet-258	291	54	even	even	ADV
admet-258	291	55	within	within	ADP
admet-258	291	56	2	2	NUM
admet-258	291	57	-	-	NOUN
admet-258	291	58	fold	fold	ADJ
admet-258	291	59	.	.	PUNCT
admet-258	292	1	the	the	DET
admet-258	292	2	difference	difference	NOUN
admet-258	292	3	to	to	ADP
admet-258	292	4	all	all	DET
admet-258	292	5	other	other	ADJ
admet-258	292	6	equilibrium	equilibrium	NOUN
admet-258	292	7	solubility	solubility	NOUN
admet-258	292	8	values	value	NOUN
admet-258	292	9	investigated	investigate	VERB
admet-258	292	10	is	be	AUX
admet-258	292	11	even	even	ADV
admet-258	292	12	more	more	ADV
admet-258	292	13	pronounced	pronounced	ADJ
admet-258	292	14	and	and	CCONJ
admet-258	292	15	full	full	ADJ
admet-258	292	16	gi	gi	NOUN
admet-258	292	17	dissolution	dissolution	NOUN
admet-258	292	18	does	do	AUX
admet-258	292	19	not	not	PART
admet-258	292	20	necessarily	necessarily	ADV
admet-258	292	21	help	help	VERB
admet-258	292	22	improving	improve	VERB
admet-258	292	23	the	the	DET
admet-258	292	24	quality	quality	NOUN
admet-258	292	25	of	of	ADP
admet-258	292	26	pbpk	pbpk	ADJ
admet-258	292	27	prediction	prediction	NOUN
admet-258	292	28	.	.	PUNCT
admet-258	293	1	the	the	DET
admet-258	293	2	example	example	NOUN
admet-258	293	3	of	of	ADP
admet-258	293	4	compound	compound	NOUN
admet-258	293	5	f	f	PROPN
admet-258	293	6	reveals	reveal	VERB
admet-258	293	7	,	,	PUNCT
admet-258	293	8	again	again	ADV
admet-258	293	9	,	,	PUNCT
admet-258	293	10	that	that	SCONJ
admet-258	293	11	there	there	PRON
admet-258	293	12	is	be	VERB
admet-258	293	13	no	no	DET
admet-258	293	14	influence	influence	NOUN
admet-258	293	15	of	of	ADP
admet-258	293	16	solubility	solubility	NOUN
admet-258	293	17	for	for	ADP
admet-258	293	18	this	this	DET
admet-258	293	19	compound	compound	NOUN
admet-258	293	20	,	,	PUNCT
admet-258	293	21	as	as	SCONJ
admet-258	293	22	already	already	ADV
admet-258	293	23	pointed	point	VERB
admet-258	293	24	out	out	ADP
admet-258	293	25	for	for	ADP
admet-258	293	26	the	the	DET
admet-258	293	27	lower	low	ADJ
admet-258	293	28	dose	dose	NOUN
admet-258	293	29	studies	study	NOUN
admet-258	293	30	.	.	PUNCT
admet-258	294	1	table	table	NOUN
admet-258	294	2	8	8	NUM
admet-258	294	3	.	.	PUNCT
admet-258	295	1	pbpk	pbpk	PROPN
admet-258	295	2	results	result	NOUN
admet-258	295	3	of	of	ADP
admet-258	295	4	cmax	cmax	NOUN
admet-258	295	5	in	in	ADP
admet-258	295	6	g	g	PROPN
admet-258	295	7	/	/	SYM
admet-258	295	8	ml	ml	X
admet-258	295	9	for	for	ADP
admet-258	295	10	higher	high	ADJ
admet-258	295	11	dose	dose	NOUN
admet-258	295	12	range	range	NOUN
admet-258	295	13	based	base	VERB
admet-258	295	14	on	on	ADP
admet-258	295	15	various	various	ADJ
admet-258	295	16	solubility	solubility	NOUN
admet-258	295	17	input	input	NOUN
admet-258	295	18	.	.	PUNCT
admet-258	296	1	cmax	cmax	NOUN
admet-258	296	2	buffer	buffer	NOUN
admet-258	296	3	,	,	PUNCT
admet-258	296	4	fassif	fassif	VERB
admet-258	296	5	,	,	PUNCT
admet-258	296	6	fassif	fassif	VERB
admet-258	296	7	with	with	ADP
admet-258	296	8	theoretical	theoretical	ADJ
admet-258	296	9	bile	bile	NOUN
admet-258	296	10	salt	salt	NOUN
admet-258	296	11	correction	correction	NOUN
admet-258	296	12	(	(	PUNCT
admet-258	296	13	cmax	cmax	NOUN
admet-258	296	14	fassif	fassif	VERB
admet-258	296	15	bile	bile	NOUN
admet-258	296	16	)	)	PUNCT
admet-258	296	17	and	and	CCONJ
admet-258	296	18	rsif	rsif	NOUN
admet-258	296	19	refer	refer	VERB
admet-258	296	20	to	to	ADP
admet-258	296	21	equilibrium	equilibrium	NOUN
admet-258	296	22	values	value	NOUN
admet-258	296	23	,	,	PUNCT
admet-258	296	24	whereas	whereas	SCONJ
admet-258	296	25	gi	gi	NOUN
admet-258	296	26	disso	disso	PROPN
admet-258	296	27	comprises	comprise	VERB
admet-258	296	28	the	the	DET
admet-258	296	29	input	input	NOUN
admet-258	296	30	of	of	ADP
admet-258	296	31	the	the	DET
admet-258	296	32	full	full	ADJ
admet-258	296	33	gi	gi	NOUN
admet-258	296	34	dissolution	dissolution	NOUN
admet-258	296	35	profile	profile	NOUN
admet-258	296	36	.	.	PUNCT
admet-258	297	1	pred	pre	VERB
admet-258	297	2	.	.	PUNCT
admet-258	298	1	vs.	vs.	X
admet-258	298	2	obs	obs	PROPN
admet-258	298	3	.	.	PUNCT
admet-258	299	1	denotes	denote	VERB
admet-258	299	2	the	the	DET
admet-258	299	3	ratio	ratio	NOUN
admet-258	299	4	of	of	ADP
admet-258	299	5	the	the	DET
admet-258	299	6	predicted	predict	VERB
admet-258	299	7	values	value	NOUN
admet-258	299	8	vs.	vs.	ADP
admet-258	299	9	the	the	DET
admet-258	299	10	observed	observed	ADJ
admet-258	299	11	cmax	cmax	NOUN
admet-258	299	12	.	.	PUNCT
admet-258	300	1	dose	dose	NOUN
admet-258	300	2	,	,	PUNCT
admet-258	300	3	mg	mg	PROPN
admet-258	300	4	/	/	SYM
admet-258	300	5	kg	kg	PROPN
admet-258	300	6	cmax	cmax	NOUN
admet-258	300	7	obs	obs	PROPN
admet-258	300	8	cmax	cmax	NOUN
admet-258	300	9	buffer	buffer	NOUN
admet-258	300	10	cmax	cmax	NOUN
admet-258	300	11	fassif	fassif	NOUN
admet-258	300	12	cmax	cmax	NOUN
admet-258	300	13	fassif	fassif	VERB
admet-258	300	14	bile	bile	NOUN
admet-258	300	15	cmax	cmax	NOUN
admet-258	300	16	rat	rat	NOUN
admet-258	300	17	fluid	fluid	ADJ
admet-258	300	18	cmax	cmax	NOUN
admet-258	300	19	gi	gi	X
admet-258	300	20	disso	disso	PROPN
admet-258	300	21	compound	compound	VERB
admet-258	300	22	a	a	DET
admet-258	300	23	30	30	NUM
admet-258	300	24	8.581	8.581	NUM
admet-258	300	25	0.047	0.047	NUM
admet-258	300	26	0.401	0.401	NUM
admet-258	300	27	0.121	0.121	NUM
admet-258	300	28	4.139	4.139	NUM
admet-258	300	29	pred	pre	VERB
admet-258	300	30	.	.	PUNCT
admet-258	301	1	vs.	vs.	X
admet-258	301	2	obs	obs	PROPN
admet-258	301	3	0.0055	0.0055	NUM
admet-258	301	4	0.0467	0.0467	NUM
admet-258	301	5	0.0141	0.0141	NUM
admet-258	301	6	0.4823	0.4823	NUM
admet-258	301	7	compound	compound	NOUN
admet-258	301	8	a	a	DET
admet-258	301	9	100	100	NUM
admet-258	301	10	18.3	18.3	NUM
admet-258	301	11	0.042	0.042	NUM
admet-258	301	12	0.468	0.468	NUM
admet-258	301	13	0.127	0.127	NUM
admet-258	301	14	4.02	4.02	NUM
admet-258	301	15	pred	pre	VERB
admet-258	301	16	.	.	PUNCT
admet-258	302	1	vs.	vs.	X
admet-258	302	2	obs	obs	PROPN
admet-258	302	3	0.0023	0.0023	NUM
admet-258	302	4	0.0256	0.0256	NUM
admet-258	302	5	0.0069	0.0069	NUM
admet-258	302	6	0.2197	0.2197	NUM
admet-258	302	7	compound	compound	NOUN
admet-258	302	8	b	b	NOUN
admet-258	302	9	30	30	NUM
admet-258	302	10	0.784	0.784	NUM
admet-258	302	11	0.022	0.022	NUM
admet-258	302	12	0.023	0.023	NUM
admet-258	302	13	0.119	0.119	NUM
admet-258	302	14	1.531	1.531	NUM
admet-258	302	15	pred	pre	VERB
admet-258	302	16	.	.	PUNCT
admet-258	303	1	vs.	vs.	X
admet-258	303	2	obs	obs	PROPN
admet-258	303	3	0.0280	0.0280	NUM
admet-258	303	4	0.0293	0.0293	NUM
admet-258	303	5	0.1518	0.1518	NUM
admet-258	303	6	1.953	1.953	NUM
admet-258	303	7	compound	compound	NOUN
admet-258	303	8	c	c	NOUN
admet-258	303	9	30	30	NUM
admet-258	303	10	0.546	0.546	NUM
admet-258	303	11	0.041	0.041	NUM
admet-258	303	12	0.101	0.101	NUM
admet-258	303	13	0.236	0.236	NUM
admet-258	303	14	0.447	0.447	NUM
admet-258	303	15	0.491	0.491	NUM
admet-258	303	16	pred	pre	VERB
admet-258	303	17	.	.	PUNCT
admet-258	304	1	vs.	vs.	X
admet-258	304	2	obs	obs	PROPN
admet-258	304	3	0.0751	0.0751	NUM
admet-258	304	4	0.1850	0.1850	NUM
admet-258	304	5	0.4322	0.4322	NUM
admet-258	304	6	0.8187	0.8187	NUM
admet-258	304	7	0.8993	0.8993	NUM
admet-258	304	8	compound	compound	NOUN
admet-258	304	9	d	d	NOUN
admet-258	304	10	30	30	NUM
admet-258	304	11	0.908	0.908	NUM
admet-258	304	12	0.095	0.095	NUM
admet-258	304	13	0.058	0.058	NUM
admet-258	304	14	0.271	0.271	NUM
admet-258	304	15	0.380	0.380	NUM
admet-258	304	16	2.04	2.04	NUM
admet-258	304	17	pred	pre	VERB
admet-258	304	18	.	.	PUNCT
admet-258	305	1	vs.	vs.	X
admet-258	305	2	obs	obs	PROPN
admet-258	305	3	0.1046	0.1046	NUM
admet-258	306	1	0.0639	0.0639	NUM
admet-258	306	2	0.2985	0.2985	NUM
admet-258	306	3	0.4185	0.4185	NUM
admet-258	306	4	2.2467	2.2467	NUM
admet-258	306	5	compound	compound	NOUN
admet-258	306	6	e	e	NOUN
admet-258	306	7	100	100	NUM
admet-258	306	8	3.592	3.592	NUM
admet-258	306	9	0.094	0.094	NUM
admet-258	306	10	0.220	0.220	NUM
admet-258	306	11	1.227	1.227	NUM
admet-258	306	12	3.869	3.869	NUM
admet-258	306	13	4.74	4.74	NUM
admet-258	306	14	pred	pre	VERB
admet-258	306	15	.	.	PUNCT
admet-258	307	1	vs.	vs.	X
admet-258	307	2	obs	obs	PROPN
admet-258	307	3	0.0262	0.0262	NUM
admet-258	307	4	0.0612	0.0612	NUM
admet-258	307	5	0.3416	0.3416	NUM
admet-258	307	6	1.077	1.077	NUM
admet-258	307	7	1.320	1.320	NUM
admet-258	307	8	compound	compound	NOUN
admet-258	307	9	f	f	NOUN
admet-258	307	10	100	100	NUM
admet-258	307	11	17.0	17.0	NUM
admet-258	307	12	26.3	26.3	NUM
admet-258	307	13	27.3	27.3	NUM
admet-258	307	14	25.9	25.9	NUM
admet-258	307	15	27.4	27.4	NUM
admet-258	307	16	27.4	27.4	NUM
admet-258	307	17	pred	pre	VERB
admet-258	307	18	.	.	PUNCT
admet-258	308	1	vs.	vs.	X
admet-258	308	2	obs	obs	PROPN
admet-258	308	3	1.547	1.547	NUM
admet-258	308	4	1.610	1.610	NUM
admet-258	308	5	1.524	1.524	NUM
admet-258	308	6	1.612	1.612	NUM
admet-258	308	7	1.612	1.612	NUM
admet-258	308	8	compound	compound	NOUN
admet-258	308	9	g	g	NOUN
admet-258	308	10	30	30	NUM
admet-258	308	11	0.813	0.813	NUM
admet-258	308	12	0.005	0.005	NUM
admet-258	308	13	0.055	0.055	NUM
admet-258	308	14	0.038	0.038	NUM
admet-258	308	15	0.274	0.274	NUM
admet-258	308	16	0.263	0.263	NUM
admet-258	308	17	pred	pre	VERB
admet-258	308	18	.	.	PUNCT
admet-258	309	1	vs.	vs.	X
admet-258	309	2	obs	obs	PROPN
admet-258	309	3	0.0062	0.0062	NUM
admet-258	309	4	0.0677	0.0677	NUM
admet-258	309	5	0.0467	0.0467	NUM
admet-258	309	6	0.3370	0.3370	NUM
admet-258	309	7	0.3235	0.3235	NUM
admet-258	309	8	prediction	prediction	NOUN
admet-258	309	9	of	of	ADP
admet-258	309	10	auc	auc	NOUN
admet-258	309	11	in	in	ADP
admet-258	309	12	the	the	DET
admet-258	309	13	dose	dose	NOUN
admet-258	309	14	range	range	NOUN
admet-258	309	15	30	30	NUM
admet-258	309	16	to	to	PART
admet-258	309	17	300	300	NUM
admet-258	309	18	mg	mg	NOUN
admet-258	309	19	/	/	SYM
admet-258	309	20	kg	kg	PROPN
admet-258	309	21	follows	follow	VERB
admet-258	309	22	the	the	DET
admet-258	309	23	same	same	ADJ
admet-258	309	24	trend	trend	NOUN
admet-258	309	25	as	as	ADP
admet-258	309	26	for	for	ADP
admet-258	309	27	cmax	cmax	NOUN
admet-258	309	28	.	.	PUNCT
admet-258	310	1	rsif	rsif	NOUN
admet-258	310	2	solubility	solubility	PROPN
admet-258	310	3	,	,	PUNCT
admet-258	310	4	besides	besides	SCONJ
admet-258	310	5	the	the	DET
admet-258	310	6	gi	gi	PROPN
admet-258	310	7	dissolution	dissolution	PROPN
admet-258	310	8	assay	assay	PROPN
admet-258	310	9	,	,	PUNCT
admet-258	310	10	provides	provide	VERB
admet-258	310	11	best	good	ADJ
admet-258	310	12	matches	match	NOUN
admet-258	310	13	of	of	ADP
admet-258	310	14	pbpk	pbpk	NOUN
admet-258	310	15	results	result	NOUN
admet-258	310	16	without	without	ADP
admet-258	310	17	a	a	DET
admet-258	310	18	tendency	tendency	NOUN
admet-258	310	19	to	to	PART
admet-258	310	20	overpredict	overpredict	VERB
admet-258	310	21	.	.	PUNCT
admet-258	311	1	for	for	ADP
admet-258	311	2	instance	instance	NOUN
admet-258	311	3	,	,	PUNCT
admet-258	311	4	for	for	ADP
admet-258	311	5	compound	compound	NOUN
admet-258	311	6	b	b	NOUN
admet-258	311	7	at	at	ADP
admet-258	311	8	a	a	DET
admet-258	311	9	dose	dose	NOUN
admet-258	311	10	of	of	ADP
admet-258	311	11	3	3	NUM
admet-258	311	12	mg	mg	PROPN
admet-258	311	13	/	/	SYM
admet-258	311	14	kg	kg	PROPN
admet-258	311	15	,	,	PUNCT
admet-258	311	16	without	without	ADP
admet-258	311	17	using	use	VERB
admet-258	311	18	the	the	DET
admet-258	311	19	rsif	rsif	NOUN
admet-258	311	20	solubility	solubility	NOUN
admet-258	311	21	but	but	CCONJ
admet-258	311	22	the	the	DET
admet-258	311	23	calculated	calculate	VERB
admet-258	311	24	solubilization	solubilization	NOUN
admet-258	311	25	ratio	ratio	NOUN
admet-258	311	26	an	an	DET
admet-258	311	27	under	under	NOUN
admet-258	311	28	-	-	PUNCT
admet-258	311	29	prediction	prediction	NOUN
admet-258	311	30	of	of	ADP
admet-258	311	31	auc	auc	NOUN
admet-258	311	32	by	by	ADP
admet-258	311	33	a	a	DET
admet-258	311	34	factor	factor	NOUN
admet-258	311	35	of	of	ADP
admet-258	311	36	5	5	NUM
admet-258	311	37	was	be	AUX
admet-258	311	38	found	find	VERB
admet-258	311	39	.	.	PUNCT
admet-258	312	1	at	at	ADP
admet-258	312	2	the	the	DET
admet-258	312	3	dose	dose	NOUN
admet-258	312	4	of	of	ADP
admet-258	312	5	30	30	NUM
admet-258	312	6	mg	mg	PROPN
admet-258	312	7	/	/	SYM
admet-258	312	8	kg	kg	PROPN
admet-258	312	9	,	,	PUNCT
admet-258	312	10	the	the	DET
admet-258	312	11	under	under	NOUN
admet-258	312	12	-	-	PUNCT
admet-258	312	13	prediction	prediction	NOUN
admet-258	312	14	was	be	AUX
admet-258	312	15	nearly	nearly	ADV
admet-258	312	16	10	10	NUM
admet-258	312	17	-	-	NUM
admet-258	312	18	fold	fold	ADJ
admet-258	312	19	,	,	PUNCT
admet-258	312	20	whereas	whereas	SCONJ
admet-258	312	21	the	the	DET
admet-258	312	22	simulation	simulation	NOUN
admet-258	312	23	based	base	VERB
admet-258	312	24	on	on	ADP
admet-258	312	25	rat	rat	NOUN
admet-258	312	26	sif	sif	PROPN
admet-258	312	27	fluid	fluid	NOUN
admet-258	312	28	led	lead	VERB
admet-258	312	29	to	to	ADP
admet-258	312	30	an	an	DET
admet-258	312	31	excellent	excellent	ADJ
admet-258	312	32	match	match	NOUN
admet-258	312	33	for	for	ADP
admet-258	312	34	auc	auc	NOUN
admet-258	312	35	with	with	ADP
admet-258	312	36	a	a	DET
admet-258	312	37	factor	factor	NOUN
admet-258	312	38	of	of	ADP
admet-258	312	39	1.3	1.3	NUM
admet-258	312	40	-	-	NUM
admet-258	312	41	fold	fold	ADV
admet-258	312	42	.	.	PUNCT
admet-258	313	1	there	there	PRON
admet-258	313	2	are	be	VERB
admet-258	313	3	still	still	ADV
admet-258	313	4	results	result	NOUN
admet-258	313	5	where	where	SCONJ
admet-258	313	6	auc	auc	NOUN
admet-258	313	7	is	be	AUX
admet-258	313	8	underpredicted	underpredicte	VERB
admet-258	313	9	by	by	ADP
admet-258	313	10	a	a	DET
admet-258	313	11	factor	factor	NOUN
admet-258	313	12	of	of	ADP
admet-258	313	13	more	more	ADJ
admet-258	313	14	than	than	ADP
admet-258	313	15	five	five	NUM
admet-258	313	16	.	.	PUNCT
admet-258	314	1	one	one	PRON
admet-258	314	2	may	may	AUX
admet-258	314	3	hypothesize	hypothesize	VERB
admet-258	314	4	that	that	SCONJ
admet-258	314	5	for	for	ADP
admet-258	314	6	these	these	DET
admet-258	314	7	cases	case	NOUN
admet-258	314	8	,	,	PUNCT
admet-258	314	9	the	the	DET
admet-258	314	10	impact	impact	NOUN
admet-258	314	11	of	of	ADP
admet-258	314	12	other	other	ADJ
admet-258	314	13	parameters	parameter	NOUN
admet-258	314	14	than	than	ADP
admet-258	314	15	solubility	solubility	NOUN
admet-258	314	16	,	,	PUNCT
admet-258	314	17	like	like	ADP
admet-258	314	18	first	first	ADJ
admet-258	314	19	pass	pass	NOUN
admet-258	314	20	extraction	extraction	NOUN
admet-258	314	21	,	,	PUNCT
admet-258	314	22	might	might	AUX
admet-258	314	23	be	be	AUX
admet-258	314	24	more	more	ADV
admet-258	314	25	important	important	ADJ
admet-258	314	26	in	in	ADP
admet-258	314	27	limiting	limit	VERB
admet-258	314	28	exposure	exposure	NOUN
admet-258	314	29	.	.	PUNCT
admet-258	315	1	our	our	PRON
admet-258	315	2	results	result	NOUN
admet-258	315	3	obtained	obtain	VERB
admet-258	315	4	with	with	ADP
admet-258	315	5	nine	nine	NUM
admet-258	315	6	compounds	compound	NOUN
admet-258	315	7	and	and	CCONJ
admet-258	315	8	across	across	ADP
admet-258	315	9	different	different	ADJ
admet-258	315	10	dose	dose	NOUN
admet-258	315	11	ranges	range	NOUN
admet-258	315	12	show	show	VERB
admet-258	315	13	that	that	SCONJ
admet-258	315	14	the	the	DET
admet-258	315	15	rsif	rsif	NOUN
admet-258	315	16	solubility	solubility	NOUN
admet-258	315	17	can	can	AUX
admet-258	315	18	be	be	AUX
admet-258	315	19	regarded	regard	VERB
admet-258	315	20	as	as	ADP
admet-258	315	21	a	a	DET
admet-258	315	22	very	very	ADV
admet-258	315	23	useful	useful	ADJ
admet-258	315	24	biorelevant	biorelevant	NOUN
admet-258	315	25	solubility	solubility	NOUN
admet-258	315	26	parameter	parameter	NOUN
admet-258	315	27	when	when	SCONJ
admet-258	315	28	performing	perform	VERB
admet-258	315	29	pbpk	pbpk	ADJ
admet-258	315	30	simulations	simulation	NOUN
admet-258	315	31	for	for	ADP
admet-258	315	32	rats	rat	NOUN
admet-258	315	33	.	.	PUNCT
admet-258	316	1	berghausen	berghausen	VERB
admet-258	316	2	et	et	PROPN
admet-258	316	3	al	al	PROPN
admet-258	316	4	.	.	PROPN
admet-258	316	5	admet	admet	PROPN
admet-258	316	6	&	&	CCONJ
admet-258	316	7	dmpk	dmpk	PROPN
admet-258	316	8	4(1	4(1	NOUN
admet-258	316	9	)	)	PUNCT
admet-258	316	10	(	(	PUNCT
admet-258	316	11	2016	2016	NUM
admet-258	316	12	)	)	PUNCT
admet-258	316	13	35	35	NUM
admet-258	316	14	-	-	SYM
admet-258	316	15	53	53	NUM
admet-258	316	16	50	50	NUM
admet-258	316	17	table	table	NOUN
admet-258	316	18	9	9	NUM
admet-258	316	19	.	.	PUNCT
admet-258	317	1	pbpk	pbpk	PROPN
admet-258	317	2	results	result	NOUN
admet-258	317	3	of	of	ADP
admet-258	317	4	auc	auc	NOUN
admet-258	317	5	(	(	PUNCT
admet-258	317	6	0	0	NUM
admet-258	317	7	-	-	PUNCT
admet-258	317	8	t	t	NOUN
admet-258	317	9	)	)	PUNCT
admet-258	317	10	in	in	ADP
admet-258	317	11	g	g	PROPN
admet-258	317	12	h	h	NOUN
admet-258	317	13	/	/	SYM
admet-258	317	14	ml	ml	X
admet-258	317	15	for	for	ADP
admet-258	317	16	higher	high	ADJ
admet-258	317	17	dose	dose	NOUN
admet-258	317	18	range	range	NOUN
admet-258	317	19	based	base	VERB
admet-258	317	20	on	on	ADP
admet-258	317	21	various	various	ADJ
admet-258	317	22	solubility	solubility	NOUN
admet-258	317	23	input	input	NOUN
admet-258	317	24	.	.	PUNCT
admet-258	318	1	auc	auc	NOUN
admet-258	318	2	buffer	buffer	NOUN
admet-258	318	3	,	,	PUNCT
admet-258	318	4	fassif	fassif	VERB
admet-258	318	5	,	,	PUNCT
admet-258	318	6	fassif	fassif	VERB
admet-258	318	7	with	with	ADP
admet-258	318	8	theoretical	theoretical	ADJ
admet-258	318	9	bile	bile	NOUN
admet-258	318	10	salt	salt	NOUN
admet-258	318	11	correction	correction	NOUN
admet-258	318	12	(	(	PUNCT
admet-258	318	13	auc	auc	X
admet-258	318	14	fassif	fassif	NOUN
admet-258	318	15	bile	bile	NOUN
admet-258	318	16	)	)	PUNCT
admet-258	318	17	and	and	CCONJ
admet-258	318	18	rsif	rsif	NOUN
admet-258	318	19	refer	refer	VERB
admet-258	318	20	to	to	ADP
admet-258	318	21	equilibrium	equilibrium	NOUN
admet-258	318	22	values	value	NOUN
admet-258	318	23	,	,	PUNCT
admet-258	318	24	whereas	whereas	SCONJ
admet-258	318	25	gi	gi	NOUN
admet-258	318	26	disso	disso	PROPN
admet-258	318	27	comprises	comprise	VERB
admet-258	318	28	the	the	DET
admet-258	318	29	input	input	NOUN
admet-258	318	30	of	of	ADP
admet-258	318	31	the	the	DET
admet-258	318	32	full	full	ADJ
admet-258	318	33	gi	gi	NOUN
admet-258	318	34	dissolution	dissolution	NOUN
admet-258	318	35	profile	profile	NOUN
admet-258	318	36	.	.	PUNCT
admet-258	319	1	pred	pre	VERB
admet-258	319	2	.	.	PUNCT
admet-258	320	1	vs.	vs.	X
admet-258	320	2	obs	obs	PROPN
admet-258	320	3	.	.	PUNCT
admet-258	321	1	denotes	denote	VERB
admet-258	321	2	the	the	DET
admet-258	321	3	ratio	ratio	NOUN
admet-258	321	4	of	of	ADP
admet-258	321	5	the	the	DET
admet-258	321	6	predicted	predict	VERB
admet-258	321	7	values	value	NOUN
admet-258	321	8	vs.	vs.	ADP
admet-258	321	9	the	the	DET
admet-258	321	10	observed	observe	VERB
admet-258	321	11	auc	auc	NOUN
admet-258	321	12	.	.	PUNCT
admet-258	322	1	dose	dose	NOUN
admet-258	322	2	,	,	PUNCT
admet-258	322	3	mg	mg	PROPN
admet-258	322	4	/	/	SYM
admet-258	322	5	kg	kg	PROPN
admet-258	322	6	auc	auc	X
admet-258	322	7	obs	obs	NOUN
admet-258	322	8	auc	auc	NOUN
admet-258	322	9	buffer	buffer	NOUN
admet-258	322	10	auc	auc	NOUN
admet-258	322	11	fassif	fassif	NOUN
admet-258	322	12	auc	auc	X
admet-258	322	13	fassif	fassif	NOUN
admet-258	322	14	bile	bile	NOUN
admet-258	322	15	auc	auc	NOUN
admet-258	322	16	rat	rat	NOUN
admet-258	322	17	fluid	fluid	NOUN
admet-258	322	18	auc	auc	NOUN
admet-258	322	19	gi	gi	X
admet-258	322	20	disso	disso	PROPN
admet-258	322	21	compound	compound	VERB
admet-258	322	22	a	a	DET
admet-258	322	23	30	30	NUM
admet-258	322	24	41.3	41.3	NUM
admet-258	322	25	0.514	0.514	NUM
admet-258	322	26	2.057	2.057	NUM
admet-258	322	27	0.861	0.861	NUM
admet-258	322	28	15.2	15.2	NUM
admet-258	322	29	pred	pre	VERB
admet-258	322	30	.	.	PUNCT
admet-258	323	1	vs.	vs.	X
admet-258	323	2	obs	obs	PROPN
admet-258	324	1	0.0124	0.0124	NUM
admet-258	324	2	0.0498	0.0498	NUM
admet-258	324	3	0.0209	0.0209	NUM
admet-258	324	4	0.3680	0.3680	NUM
admet-258	324	5	compound	compound	VERB
admet-258	324	6	a	a	DET
admet-258	324	7	100	100	NUM
admet-258	324	8	97.5	97.5	NUM
admet-258	324	9	0.297	0.297	NUM
admet-258	324	10	2.48	2.48	NUM
admet-258	324	11	0.766	0.766	NUM
admet-258	324	12	19.2	19.2	NUM
admet-258	324	13	pred	pre	VERB
admet-258	324	14	.	.	PUNCT
admet-258	325	1	vs.	vs.	X
admet-258	325	2	obs	obs	PROPN
admet-258	325	3	0.0030	0.0030	NUM
admet-258	325	4	0.0254	0.0254	NUM
admet-258	325	5	0.0079	0.0079	NUM
admet-258	325	6	0.1969	0.1969	NUM
admet-258	325	7	compound	compound	NOUN
admet-258	325	8	b	b	PROPN
admet-258	325	9	30	30	NUM
admet-258	325	10	11.4	11.4	NUM
admet-258	325	11	0.274	0.274	NUM
admet-258	325	12	0.274	0.274	NUM
admet-258	325	13	1.274	1.274	NUM
admet-258	325	14	14.75	14.75	NUM
admet-258	325	15	pred	pre	VERB
admet-258	325	16	.	.	PUNCT
admet-258	326	1	vs.	vs.	X
admet-258	326	2	obs	obs	PROPN
admet-258	326	3	0.0240	0.0240	NUM
admet-258	326	4	0.0240	0.0240	NUM
admet-258	326	5	0.1118	0.1118	NUM
admet-258	326	6	1.2939	1.2939	NUM
admet-258	326	7	compound	compound	NOUN
admet-258	326	8	c	c	NOUN
admet-258	326	9	30	30	NUM
admet-258	326	10	6.99	6.99	NUM
admet-258	326	11	0.175	0.175	NUM
admet-258	326	12	0.317	0.317	NUM
admet-258	326	13	0.521	0.521	NUM
admet-258	326	14	0.706	0.706	NUM
admet-258	326	15	0.874	0.874	NUM
admet-258	326	16	pred	pre	VERB
admet-258	326	17	.	.	PUNCT
admet-258	327	1	vs.	vs.	X
admet-258	327	2	obs	obs	PROPN
admet-258	327	3	0.0250	0.0250	NUM
admet-258	327	4	0.0454	0.0454	NUM
admet-258	327	5	0.0745	0.0745	NUM
admet-258	327	6	0.1010	0.1010	NUM
admet-258	327	7	0.1250	0.1250	NUM
admet-258	327	8	compound	compound	NOUN
admet-258	327	9	d	d	NOUN
admet-258	327	10	30	30	NUM
admet-258	327	11	14.83	14.83	NUM
admet-258	327	12	1.139	1.139	NUM
admet-258	327	13	0.707	0.707	NUM
admet-258	327	14	2.900	2.900	NUM
admet-258	327	15	4.27	4.27	NUM
admet-258	327	16	18.02	18.02	NUM
admet-258	327	17	pred	pre	VERB
admet-258	327	18	.	.	PUNCT
admet-258	328	1	vs.	vs.	X
admet-258	328	2	obs	obs	PROPN
admet-258	328	3	0.0768	0.0768	NUM
admet-258	329	1	0.0477	0.0477	NUM
admet-258	329	2	0.1955	0.1955	NUM
admet-258	329	3	0.2879	0.2879	NUM
admet-258	329	4	1.215	1.215	NUM
admet-258	329	5	compound	compound	NOUN
admet-258	329	6	e	e	NOUN
admet-258	329	7	100	100	NUM
admet-258	329	8	56.9	56.9	NUM
admet-258	329	9	1.14	1.14	NUM
admet-258	329	10	4.80	4.80	NUM
admet-258	329	11	15.1	15.1	NUM
admet-258	329	12	35.8	35.8	NUM
admet-258	329	13	44.0	44.0	NUM
admet-258	329	14	pred	pre	VERB
admet-258	329	15	.	.	PUNCT
admet-258	330	1	vs.	vs.	X
admet-258	330	2	obs	obs	PROPN
admet-258	330	3	0.0200	0.0200	NUM
admet-258	330	4	0.0844	0.0844	NUM
admet-258	330	5	0.2654	0.2654	NUM
admet-258	330	6	0.6292	0.6292	NUM
admet-258	330	7	0.7733	0.7733	NUM
admet-258	330	8	compound	compound	NOUN
admet-258	330	9	f	f	PROPN
admet-258	330	10	100	100	NUM
admet-258	330	11	268	268	NUM
admet-258	330	12	78.0	78.0	NUM
admet-258	330	13	78.1	78.1	NUM
admet-258	330	14	78.2	78.2	NUM
admet-258	330	15	78.1	78.1	NUM
admet-258	330	16	78.1	78.1	NUM
admet-258	330	17	pred	pre	VERB
admet-258	330	18	.	.	PUNCT
admet-258	331	1	vs.	vs.	ADP
admet-258	331	2	obs	obs	PROPN
admet-258	331	3	0.2910	0.2910	NUM
admet-258	331	4	0.2914	0.2914	NUM
admet-258	331	5	0.2918	0.2918	NUM
admet-258	331	6	0.2914	0.2914	NUM
admet-258	331	7	0.2914	0.2914	NUM
admet-258	331	8	compound	compound	NOUN
admet-258	331	9	g	g	NOUN
admet-258	331	10	30	30	NUM
admet-258	331	11	6.25	6.25	NUM
admet-258	331	12	0.033	0.033	NUM
admet-258	331	13	0.279	0.279	NUM
admet-258	331	14	0.202	0.202	NUM
admet-258	331	15	1.249	1.249	NUM
admet-258	331	16	1.225	1.225	NUM
admet-258	331	17	pred	pre	VERB
admet-258	331	18	.	.	PUNCT
admet-258	332	1	vs.	vs.	X
admet-258	332	2	obs	obs	PROPN
admet-258	332	3	0.0052	0.0052	NUM
admet-258	332	4	0.0446	0.0446	NUM
admet-258	332	5	0.0323	0.0323	NUM
admet-258	332	6	0.1998	0.1998	NUM
admet-258	332	7	0.1960	0.1960	NUM
admet-258	332	8	admet	admet	PROPN
admet-258	332	9	&	&	CCONJ
admet-258	332	10	dmpk	dmpk	PROPN
admet-258	332	11	4(1	4(1	NOUN
admet-258	332	12	)	)	PUNCT
admet-258	332	13	(	(	PUNCT
admet-258	332	14	2016	2016	NUM
admet-258	332	15	)	)	PUNCT
admet-258	332	16	35	35	NUM
admet-258	332	17	-	-	SYM
admet-258	332	18	53	53	NUM
admet-258	332	19	simulated	simulate	VERB
admet-258	332	20	rat	rat	NOUN
admet-258	332	21	intestinal	intestinal	ADJ
admet-258	332	22	fluid	fluid	ADJ
admet-258	332	23	doi	doi	NOUN
admet-258	332	24	:	:	PUNCT
admet-258	332	25	10.5599	10.5599	NUM
admet-258	332	26	/	/	SYM
admet-258	332	27	admet.4.1.258	admet.4.1.258	PROPN
admet-258	332	28	51	51	NUM
admet-258	332	29	-2.5	-2.5	NOUN
admet-258	332	30	-2	-2	INTJ
admet-258	332	31	-1.5	-1.5	NUM
admet-258	332	32	-1	-1	PROPN
admet-258	332	33	-0.5	-0.5	X
admet-258	332	34	0	0	NUM
admet-258	332	35	0.5	0.5	NUM
admet-258	332	36	lo	lo	PROPN
admet-258	332	37	g	g	PROPN
admet-258	332	38	(	(	PUNCT
admet-258	332	39	p	p	X
admet-258	332	40	re	re	PROPN
admet-258	332	41	d	d	NOUN
admet-258	332	42	ic	ic	X
admet-258	332	43	te	te	PROPN
admet-258	332	44	d	d	PROPN
admet-258	332	45	v	v	PROPN
admet-258	332	46	s	s	NOUN
admet-258	332	47	.	.	PUNCT
admet-258	333	1	o	o	X
admet-258	333	2	b	b	X
admet-258	333	3	s	s	PROPN
admet-258	333	4	e	e	X
admet-258	333	5	rv	rv	X
admet-258	333	6	e	e	PROPN
admet-258	333	7	d	d	PROPN
admet-258	333	8	)	)	PUNCT
admet-258	333	9	cmax	cmax	NOUN
admet-258	333	10	buffer	buffer	NOUN
admet-258	333	11	cmax	cmax	NOUN
admet-258	333	12	fassif	fassif	NOUN
admet-258	333	13	cmax	cmax	NOUN
admet-258	333	14	fassif	fassif	VERB
admet-258	333	15	bile	bile	NOUN
admet-258	333	16	cmax	cmax	NOUN
admet-258	333	17	rat	rat	NOUN
admet-258	333	18	fluid	fluid	ADJ
admet-258	333	19	cmax	cmax	NOUN
admet-258	333	20	gi	gi	X
admet-258	333	21	disso	disso	PROPN
admet-258	333	22	cpd	cpd	PROPN
admet-258	333	23	a	a	DET
admet-258	333	24	cpd	cpd	PROPN
admet-258	333	25	b	b	PROPN
admet-258	333	26	cpd	cpd	PROPN
admet-258	333	27	c	c	PROPN
admet-258	333	28	cpd	cpd	PROPN
admet-258	333	29	d	d	PROPN
admet-258	333	30	cpd	cpd	PROPN
admet-258	333	31	e	e	PROPN
admet-258	333	32	cpd	cpd	PROPN
admet-258	333	33	f	f	PROPN
admet-258	333	34	cpd	cpd	PROPN
admet-258	333	35	g	g	PROPN
admet-258	333	36	-2.5	-2.5	PROPN
admet-258	333	37	-2	-2	INTJ
admet-258	334	1	-1.5	-1.5	NUM
admet-258	334	2	-1	-1	PROPN
admet-258	334	3	-0.5	-0.5	X
admet-258	334	4	0	0	NUM
admet-258	334	5	0.5	0.5	NUM
admet-258	334	6	lo	lo	PROPN
admet-258	334	7	g	g	PROPN
admet-258	334	8	(	(	PUNCT
admet-258	334	9	p	p	X
admet-258	334	10	re	re	PROPN
admet-258	334	11	d	d	NOUN
admet-258	334	12	ic	ic	X
admet-258	334	13	te	te	PROPN
admet-258	334	14	d	d	PROPN
admet-258	334	15	v	v	PROPN
admet-258	334	16	s	s	NOUN
admet-258	334	17	.	.	PUNCT
admet-258	335	1	o	o	X
admet-258	336	1	b	b	X
admet-258	336	2	s	s	PROPN
admet-258	336	3	e	e	X
admet-258	336	4	rv	rv	X
admet-258	336	5	e	e	PROPN
admet-258	336	6	d	d	PROPN
admet-258	336	7	)	)	PUNCT
admet-258	336	8	auc	auc	NOUN
admet-258	336	9	buffer	buffer	NOUN
admet-258	336	10	auc	auc	NOUN
admet-258	336	11	fassif	fassif	NOUN
admet-258	336	12	auc	auc	X
admet-258	336	13	fassif	fassif	NOUN
admet-258	336	14	bile	bile	NOUN
admet-258	336	15	auc	auc	NOUN
admet-258	336	16	rat	rat	NOUN
admet-258	336	17	fluid	fluid	ADJ
admet-258	336	18	auc	auc	NOUN
admet-258	336	19	gi	gi	X
admet-258	336	20	disso	disso	PROPN
admet-258	336	21	cpd	cpd	PROPN
admet-258	336	22	a	a	DET
admet-258	336	23	cpd	cpd	PROPN
admet-258	336	24	b	b	PROPN
admet-258	336	25	cpd	cpd	PROPN
admet-258	336	26	c	c	PROPN
admet-258	336	27	cpd	cpd	PROPN
admet-258	336	28	d	d	PROPN
admet-258	336	29	cpd	cpd	PROPN
admet-258	336	30	e	e	PROPN
admet-258	336	31	cpd	cpd	PROPN
admet-258	336	32	f	f	PROPN
admet-258	336	33	cpd	cpd	PROPN
admet-258	336	34	g	g	PROPN
admet-258	336	35	figure	figure	NOUN
admet-258	336	36	5	5	NUM
admet-258	336	37	.	.	PUNCT
admet-258	337	1	observed	observe	VERB
admet-258	337	2	a	a	DET
admet-258	337	3	)	)	PUNCT
admet-258	337	4	cmax	cmax	NOUN
admet-258	337	5	and	and	CCONJ
admet-258	337	6	b	b	X
admet-258	337	7	)	)	PUNCT
admet-258	337	8	auc	auc	NOUN
admet-258	337	9	results	result	NOUN
admet-258	337	10	from	from	ADP
admet-258	337	11	simulations	simulation	NOUN
admet-258	337	12	performed	perform	VERB
admet-258	337	13	on	on	ADP
admet-258	337	14	studies	study	NOUN
admet-258	337	15	comprising	comprise	VERB
admet-258	337	16	doses	dose	NOUN
admet-258	337	17	from	from	ADP
admet-258	337	18	a	a	DET
admet-258	337	19	30	30	NUM
admet-258	337	20	to	to	PART
admet-258	337	21	300	300	NUM
admet-258	337	22	mg	mg	NOUN
admet-258	337	23	/	/	SYM
admet-258	337	24	kg	kg	PROPN
admet-258	337	25	dose	dose	VERB
admet-258	337	26	conclusions	conclusion	NOUN
admet-258	337	27	biorelevant	biorelevant	PROPN
admet-258	337	28	solubility	solubility	NOUN
admet-258	337	29	parameters	parameter	NOUN
admet-258	337	30	can	can	AUX
admet-258	337	31	be	be	AUX
admet-258	337	32	markedly	markedly	ADV
admet-258	337	33	different	different	ADJ
admet-258	337	34	across	across	ADP
admet-258	337	35	species	specie	NOUN
admet-258	337	36	.	.	PUNCT
admet-258	338	1	for	for	ADP
admet-258	338	2	proper	proper	ADJ
admet-258	338	3	prediction	prediction	NOUN
admet-258	338	4	of	of	ADP
admet-258	338	5	solubility	solubility	NOUN
admet-258	338	6	mediated	mediate	VERB
admet-258	338	7	exposure	exposure	NOUN
admet-258	338	8	limitation	limitation	NOUN
admet-258	338	9	in	in	ADP
admet-258	338	10	human	human	NOUN
admet-258	338	11	,	,	PUNCT
admet-258	338	12	one	one	PRON
admet-258	338	13	needs	need	VERB
admet-258	338	14	to	to	PART
admet-258	338	15	understand	understand	VERB
admet-258	338	16	the	the	DET
admet-258	338	17	solubility	solubility	NOUN
admet-258	338	18	limitation	limitation	NOUN
admet-258	338	19	across	across	ADP
admet-258	338	20	in	in	ADP
admet-258	338	21	vivo	vivo	ADJ
admet-258	338	22	species	specie	NOUN
admet-258	338	23	.	.	PUNCT
admet-258	339	1	a	a	DET
admet-258	339	2	good	good	ADJ
admet-258	339	3	exposure	exposure	NOUN
admet-258	339	4	in	in	ADP
admet-258	339	5	rats	rat	NOUN
admet-258	339	6	will	will	AUX
admet-258	339	7	not	not	PART
admet-258	339	8	necessarily	necessarily	ADV
admet-258	339	9	translate	translate	VERB
admet-258	339	10	into	into	ADP
admet-258	339	11	acceptable	acceptable	ADJ
admet-258	339	12	human	human	ADJ
admet-258	339	13	drug	drug	NOUN
admet-258	339	14	absorption	absorption	NOUN
admet-258	339	15	,	,	PUNCT
admet-258	339	16	if	if	SCONJ
admet-258	339	17	solubility	solubility	NOUN
admet-258	339	18	is	be	AUX
admet-258	339	19	mainly	mainly	ADV
admet-258	339	20	driven	drive	VERB
admet-258	339	21	by	by	ADP
admet-258	339	22	bile	bile	NOUN
admet-258	339	23	salt	salt	NOUN
admet-258	339	24	solubilization	solubilization	NOUN
admet-258	339	25	,	,	PUNCT
admet-258	339	26	or	or	CCONJ
admet-258	339	27	may	may	AUX
admet-258	339	28	lead	lead	VERB
admet-258	339	29	to	to	ADP
admet-258	339	30	an	an	DET
admet-258	339	31	undesired	undesired	ADJ
admet-258	339	32	absorption	absorption	NOUN
admet-258	339	33	profile	profile	NOUN
admet-258	339	34	,	,	PUNCT
admet-258	339	35	like	like	ADP
admet-258	339	36	a	a	DET
admet-258	339	37	strong	strong	ADJ
admet-258	339	38	food	food	NOUN
admet-258	339	39	effect	effect	NOUN
admet-258	339	40	.	.	PUNCT
admet-258	340	1	even	even	ADV
admet-258	340	2	good	good	ADJ
admet-258	340	3	exposure	exposure	NOUN
admet-258	340	4	in	in	ADP
admet-258	340	5	a	a	DET
admet-258	340	6	non	non	ADJ
admet-258	340	7	-	-	ADJ
admet-258	340	8	rodent	rodent	ADJ
admet-258	340	9	species	specie	NOUN
admet-258	340	10	,	,	PUNCT
admet-258	340	11	like	like	ADP
admet-258	340	12	dog	dog	NOUN
admet-258	340	13	,	,	PUNCT
admet-258	340	14	might	might	AUX
admet-258	340	15	not	not	PART
admet-258	340	16	be	be	AUX
admet-258	340	17	indicative	indicative	ADJ
admet-258	340	18	of	of	ADP
admet-258	340	19	the	the	DET
admet-258	340	20	situation	situation	NOUN
admet-258	340	21	in	in	ADP
admet-258	340	22	humans	human	NOUN
admet-258	340	23	,	,	PUNCT
admet-258	340	24	as	as	SCONJ
admet-258	340	25	the	the	DET
admet-258	340	26	dog	dog	NOUN
admet-258	340	27	intestinal	intestinal	ADJ
admet-258	340	28	fluid	fluid	NOUN
admet-258	340	29	still	still	ADV
admet-258	340	30	contains	contain	VERB
admet-258	340	31	bile	bile	NOUN
admet-258	340	32	salts	salt	NOUN
admet-258	340	33	at	at	ADP
admet-258	340	34	a	a	DET
admet-258	340	35	level	level	NOUN
admet-258	340	36	that	that	PRON
admet-258	340	37	is	be	AUX
admet-258	340	38	close	close	ADJ
admet-258	340	39	to	to	ADP
admet-258	340	40	the	the	DET
admet-258	340	41	post	post	ADJ
admet-258	340	42	-	-	ADJ
admet-258	340	43	prandial	prandial	ADJ
admet-258	340	44	situation	situation	NOUN
admet-258	340	45	in	in	ADP
admet-258	340	46	humans	human	NOUN
admet-258	340	47	.	.	PUNCT
admet-258	341	1	a	a	DET
admet-258	341	2	)	)	PUNCT
admet-258	341	3	b	b	NOUN
admet-258	341	4	)	)	PUNCT
admet-258	341	5	berghausen	berghausen	NOUN
admet-258	341	6	et	et	PROPN
admet-258	341	7	al	al	PROPN
admet-258	341	8	.	.	PROPN
admet-258	341	9	admet	admet	PROPN
admet-258	341	10	&	&	CCONJ
admet-258	341	11	dmpk	dmpk	PROPN
admet-258	341	12	4(1	4(1	NOUN
admet-258	341	13	)	)	PUNCT
admet-258	341	14	(	(	PUNCT
admet-258	341	15	2016	2016	NUM
admet-258	341	16	)	)	PUNCT
admet-258	341	17	35	35	NUM
admet-258	341	18	-	-	SYM
admet-258	341	19	53	53	NUM
admet-258	341	20	52	52	NUM
admet-258	341	21	a	a	DET
admet-258	341	22	better	well	ADJ
admet-258	341	23	understanding	understanding	NOUN
admet-258	341	24	of	of	ADP
admet-258	341	25	the	the	DET
admet-258	341	26	impact	impact	NOUN
admet-258	341	27	of	of	ADP
admet-258	341	28	solubility	solubility	NOUN
admet-258	341	29	when	when	SCONJ
admet-258	341	30	drug	drug	NOUN
admet-258	341	31	absorption	absorption	NOUN
admet-258	341	32	is	be	AUX
admet-258	341	33	studied	study	VERB
admet-258	341	34	in	in	ADP
admet-258	341	35	various	various	ADJ
admet-258	341	36	species	specie	NOUN
admet-258	341	37	helps	help	VERB
admet-258	341	38	to	to	PART
admet-258	341	39	lower	lower	VERB
admet-258	341	40	the	the	DET
admet-258	341	41	risk	risk	NOUN
admet-258	341	42	of	of	ADP
admet-258	341	43	failure	failure	NOUN
admet-258	341	44	in	in	ADP
admet-258	341	45	clinical	clinical	ADJ
admet-258	341	46	studies	study	NOUN
admet-258	341	47	.	.	PUNCT
admet-258	342	1	for	for	ADP
admet-258	342	2	this	this	PRON
admet-258	342	3	,	,	PUNCT
admet-258	342	4	a	a	DET
admet-258	342	5	rat	rat	NOUN
admet-258	342	6	simulated	simulate	VERB
admet-258	342	7	intestinal	intestinal	ADJ
admet-258	342	8	fluid	fluid	NOUN
admet-258	342	9	(	(	PUNCT
admet-258	342	10	rsif	rsif	NOUN
admet-258	342	11	)	)	PUNCT
admet-258	342	12	is	be	AUX
admet-258	342	13	proposed	propose	VERB
admet-258	342	14	to	to	PART
admet-258	342	15	support	support	VERB
admet-258	342	16	understanding	understand	VERB
admet-258	342	17	the	the	DET
admet-258	342	18	role	role	NOUN
admet-258	342	19	that	that	PRON
admet-258	342	20	solubility	solubility	NOUN
admet-258	342	21	plays	play	VERB
admet-258	342	22	for	for	ADP
admet-258	342	23	absorption	absorption	NOUN
admet-258	342	24	of	of	ADP
admet-258	342	25	a	a	DET
admet-258	342	26	particular	particular	ADJ
admet-258	342	27	drug	drug	NOUN
admet-258	342	28	candidate	candidate	NOUN
admet-258	342	29	.	.	PUNCT
admet-258	343	1	the	the	DET
admet-258	343	2	proposed	propose	VERB
admet-258	343	3	rat	rat	NOUN
admet-258	343	4	sif	sif	NOUN
admet-258	343	5	greatly	greatly	ADV
admet-258	343	6	improves	improve	VERB
admet-258	343	7	the	the	DET
admet-258	343	8	quality	quality	NOUN
admet-258	343	9	of	of	ADP
admet-258	343	10	pbpk	pbpk	ADJ
admet-258	343	11	predictions	prediction	NOUN
admet-258	343	12	in	in	ADP
admet-258	343	13	rats	rat	NOUN
admet-258	343	14	.	.	PUNCT
admet-258	344	1	it	it	PRON
admet-258	344	2	explains	explain	VERB
admet-258	344	3	why	why	SCONJ
admet-258	344	4	some	some	DET
admet-258	344	5	compounds	compound	NOUN
admet-258	344	6	that	that	PRON
admet-258	344	7	are	be	AUX
admet-258	344	8	low	low	ADV
admet-258	344	9	soluble	soluble	ADJ
admet-258	344	10	in	in	ADP
admet-258	344	11	aqueous	aqueous	ADJ
admet-258	344	12	media	medium	NOUN
admet-258	344	13	nevertheless	nevertheless	ADV
admet-258	344	14	show	show	VERB
admet-258	344	15	good	good	ADJ
admet-258	344	16	p.o	p.o	PROPN
admet-258	344	17	.	.	PROPN
admet-258	344	18	exposure	exposure	NOUN
admet-258	344	19	in	in	ADP
admet-258	344	20	rats	rat	NOUN
admet-258	344	21	and	and	CCONJ
admet-258	344	22	why	why	SCONJ
admet-258	344	23	this	this	PRON
admet-258	344	24	might	might	AUX
admet-258	344	25	not	not	PART
admet-258	344	26	always	always	ADV
admet-258	344	27	translate	translate	VERB
admet-258	344	28	to	to	ADP
admet-258	344	29	higher	high	ADJ
admet-258	344	30	species	specie	NOUN
admet-258	344	31	.	.	PUNCT
admet-258	345	1	the	the	DET
admet-258	345	2	results	result	NOUN
admet-258	345	3	presented	present	VERB
admet-258	345	4	in	in	ADP
admet-258	345	5	this	this	DET
admet-258	345	6	study	study	NOUN
admet-258	345	7	allow	allow	VERB
admet-258	345	8	for	for	ADP
admet-258	345	9	a	a	DET
admet-258	345	10	better	well	ADJ
admet-258	345	11	prediction	prediction	NOUN
admet-258	345	12	of	of	ADP
admet-258	345	13	exposure	exposure	NOUN
admet-258	345	14	in	in	ADP
admet-258	345	15	rats	rat	NOUN
admet-258	345	16	across	across	ADP
admet-258	345	17	the	the	DET
admet-258	345	18	dose	dose	ADJ
admet-258	345	19	range	range	NOUN
admet-258	345	20	of	of	ADP
admet-258	345	21	interest	interest	NOUN
admet-258	345	22	.	.	PUNCT
admet-258	346	1	in	in	ADP
admet-258	346	2	addition	addition	NOUN
admet-258	346	3	,	,	PUNCT
admet-258	346	4	a	a	DET
admet-258	346	5	better	well	ADJ
admet-258	346	6	understanding	understanding	NOUN
admet-258	346	7	of	of	ADP
admet-258	346	8	solubility	solubility	NOUN
admet-258	346	9	mediated	mediate	VERB
admet-258	346	10	exposure	exposure	NOUN
admet-258	346	11	in	in	ADP
admet-258	346	12	rats	rat	NOUN
admet-258	346	13	will	will	AUX
admet-258	346	14	help	help	VERB
admet-258	346	15	to	to	PART
admet-258	346	16	better	well	ADV
admet-258	346	17	anticipate	anticipate	VERB
admet-258	346	18	the	the	DET
admet-258	346	19	risk	risk	NOUN
admet-258	346	20	of	of	ADP
admet-258	346	21	solubility	solubility	NOUN
admet-258	346	22	limited	limit	VERB
admet-258	346	23	exposure	exposure	NOUN
admet-258	346	24	in	in	ADP
admet-258	346	25	higher	high	ADJ
admet-258	346	26	species	specie	NOUN
admet-258	346	27	and	and	CCONJ
admet-258	346	28	ultimately	ultimately	ADV
admet-258	346	29	in	in	ADP
admet-258	346	30	humans	human	NOUN
admet-258	346	31	.	.	PUNCT
admet-258	347	1	acknowledgements	acknowledgement	NOUN
admet-258	347	2	the	the	DET
admet-258	347	3	authors	author	NOUN
admet-258	347	4	gratefully	gratefully	ADV
admet-258	347	5	thank	thank	VERB
admet-258	347	6	daniel	daniel	PROPN
admet-258	347	7	gosling	gosling	PROPN
admet-258	347	8	and	and	CCONJ
admet-258	347	9	philippe	philippe	PROPN
admet-258	347	10	monbaron	monbaron	NOUN
admet-258	347	11	for	for	ADP
admet-258	347	12	performing	perform	VERB
admet-258	347	13	the	the	DET
admet-258	347	14	solubility	solubility	NOUN
admet-258	347	15	and	and	CCONJ
admet-258	347	16	dissolution	dissolution	ADJ
admet-258	347	17	experiments	experiment	NOUN
admet-258	347	18	.	.	PUNCT
admet-258	348	1	further	far	ADV
admet-258	348	2	we	we	PRON
admet-258	348	3	greatly	greatly	ADV
admet-258	348	4	acknowledge	acknowledge	VERB
admet-258	348	5	the	the	DET
admet-258	348	6	contribution	contribution	NOUN
admet-258	348	7	of	of	ADP
admet-258	348	8	angus	angus	ADJ
admet-258	348	9	hibbins	hibbin	NOUN
admet-258	348	10	to	to	ADP
admet-258	348	11	the	the	DET
admet-258	348	12	development	development	NOUN
admet-258	348	13	of	of	ADP
admet-258	348	14	rsif	rsif	PROPN
admet-258	348	15	.	.	PUNCT
admet-258	349	1	references	reference	NOUN
admet-258	349	2	[	[	X
admet-258	349	3	1	1	NUM
admet-258	349	4	]	]	X
admet-258	349	5	e.s	e.s	PROPN
admet-258	349	6	.	.	PROPN
admet-258	349	7	kostewicz	kostewicz	PROPN
admet-258	349	8	,	,	PUNCT
admet-258	349	9	l.	l.	PROPN
admet-258	349	10	aarons	aarons	PROPN
admet-258	349	11	,	,	PUNCT
admet-258	349	12	m.	m.	NOUN
admet-258	349	13	bergstrand	bergstrand	PROPN
admet-258	349	14	,	,	PUNCT
admet-258	349	15	m.b	m.b	PROPN
admet-258	349	16	.	.	PROPN
admet-258	349	17	bolger	bolger	PROPN
admet-258	349	18	,	,	PUNCT
admet-258	349	19	a.	a.	NOUN
admet-258	349	20	galetin	galetin	PROPN
admet-258	349	21	,	,	PUNCT
admet-258	349	22	o.	o.	PROPN
admet-258	349	23	hatley	hatley	PROPN
admet-258	349	24	,	,	PUNCT
admet-258	349	25	m.	m.	NOUN
admet-258	349	26	jamei	jamei	PROPN
admet-258	349	27	,	,	PUNCT
admet-258	349	28	r.	r.	PROPN
admet-258	349	29	lloyd	lloyd	PROPN
admet-258	349	30	,	,	PUNCT
admet-258	349	31	x.	x.	PROPN
admet-258	349	32	pepin	pepin	PROPN
admet-258	349	33	,	,	PUNCT
admet-258	349	34	a.	a.	PROPN
admet-258	349	35	rostami	rostami	PROPN
admet-258	349	36	-	-	PUNCT
admet-258	349	37	hodjegan	hodjegan	PROPN
admet-258	349	38	,	,	PUNCT
admet-258	349	39	e.	e.	PROPN
admet-258	349	40	sjögren	sjögren	PROPN
admet-258	349	41	,	,	PUNCT
admet-258	349	42	c.	c.	PROPN
admet-258	349	43	tannergren	tannergren	PROPN
admet-258	349	44	,	,	PUNCT
admet-258	349	45	d.b	d.b	PROPN
admet-258	349	46	.	.	PROPN
admet-258	349	47	turner	turner	PROPN
admet-258	349	48	,	,	PUNCT
admet-258	349	49	c.	c.	PROPN
admet-258	349	50	wagner	wagner	PROPN
admet-258	349	51	,	,	PUNCT
admet-258	349	52	w.	w.	PROPN
admet-258	349	53	weitschies	weitschies	PROPN
admet-258	349	54	,	,	PUNCT
admet-258	349	55	j.	j.	PROPN
admet-258	349	56	dressman	dressman	PROPN
admet-258	349	57	,	,	PUNCT
admet-258	349	58	european	european	PROPN
admet-258	349	59	journal	journal	PROPN
admet-258	349	60	of	of	ADP
admet-258	349	61	pharmaceutical	pharmaceutical	PROPN
admet-258	349	62	sciences	science	NOUN
admet-258	349	63	57	57	NUM
admet-258	349	64	(	(	PUNCT
admet-258	349	65	2014	2014	NUM
admet-258	349	66	)	)	PUNCT
admet-258	349	67	300	300	NUM
admet-258	349	68	-	-	NUM
admet-258	349	69	321	321	NUM
admet-258	349	70	.	.	PUNCT
admet-258	350	1	[	[	X
admet-258	350	2	2	2	X
admet-258	350	3	]	]	X
admet-258	350	4	e.l	e.l	PROPN
admet-258	350	5	.	.	PROPN
admet-258	350	6	mcconnel	mcconnel	PROPN
admet-258	350	7	,	,	PUNCT
admet-258	350	8	a.w	a.w	PROPN
admet-258	350	9	basit	basit	PROPN
admet-258	350	10	,	,	PUNCT
admet-258	350	11	s.	s.	PROPN
admet-258	350	12	murdan	murdan	PROPN
admet-258	350	13	,	,	PUNCT
admet-258	350	14	the	the	DET
admet-258	350	15	journal	journal	NOUN
admet-258	350	16	of	of	ADP
admet-258	350	17	pharmacy	pharmacy	NOUN
admet-258	350	18	and	and	CCONJ
admet-258	350	19	pharmacology	pharmacology	NOUN
admet-258	350	20	60(1	60(1	NUM
admet-258	350	21	)	)	PUNCT
admet-258	350	22	(	(	PUNCT
admet-258	350	23	2008	2008	NUM
admet-258	350	24	)	)	PUNCT
admet-258	350	25	6370	6370	NUM
admet-258	350	26	.	.	PUNCT
admet-258	351	1	[	[	X
admet-258	351	2	3	3	X
admet-258	351	3	]	]	X
admet-258	351	4	r.	r.	PROPN
admet-258	351	5	holm	holm	PROPN
admet-258	351	6	,	,	PUNCT
admet-258	351	7	a.	a.	NOUN
admet-258	351	8	mullertz	mullertz	NOUN
admet-258	351	9	,	,	PUNCT
admet-258	351	10	h.	h.	PROPN
admet-258	351	11	mu	mu	PROPN
admet-258	351	12	,	,	PUNCT
admet-258	351	13	international	international	ADJ
admet-258	351	14	journal	journal	NOUN
admet-258	351	15	of	of	ADP
admet-258	351	16	pharmaceutics	pharmaceutic	NOUN
admet-258	351	17	453(1	453(1	NUM
admet-258	351	18	)	)	PUNCT
admet-258	351	19	(	(	PUNCT
admet-258	351	20	2013	2013	NUM
admet-258	351	21	)	)	PUNCT
admet-258	351	22	44	44	NUM
admet-258	351	23	-	-	SYM
admet-258	351	24	55	55	NUM
admet-258	351	25	.	.	PUNCT
admet-258	352	1	[	[	X
admet-258	352	2	4	4	X
admet-258	352	3	]	]	X
admet-258	352	4	g.	g.	PROPN
admet-258	352	5	amidon	amidon	PROPN
admet-258	352	6	,	,	PUNCT
admet-258	352	7	h.	h.	PROPN
admet-258	352	8	lennernäs	lennernäs	PROPN
admet-258	352	9	,	,	PUNCT
admet-258	352	10	v.	v.	CCONJ
admet-258	352	11	shah	shah	PROPN
admet-258	352	12	,	,	PUNCT
admet-258	352	13	j.	j.	PROPN
admet-258	352	14	crison	crison	PROPN
admet-258	352	15	,	,	PUNCT
admet-258	352	16	pharmaceutical	pharmaceutical	ADJ
admet-258	352	17	research	research	NOUN
admet-258	352	18	12(3	12(3	PROPN
admet-258	352	19	)	)	PUNCT
admet-258	352	20	(	(	PUNCT
admet-258	352	21	1995	1995	NUM
admet-258	352	22	)	)	PUNCT
admet-258	352	23	413	413	NUM
admet-258	352	24	-	-	SYM
admet-258	352	25	420	420	NUM
admet-258	352	26	.	.	PUNCT
admet-258	353	1	[	[	X
admet-258	353	2	5	5	X
admet-258	353	3	]	]	PUNCT
admet-258	353	4	h.	h.	PROPN
admet-258	353	5	jones	jones	PROPN
admet-258	353	6	,	,	PUNCT
admet-258	353	7	n.	n.	PROPN
admet-258	353	8	parrott	parrott	PROPN
admet-258	353	9	,	,	PUNCT
admet-258	353	10	g.	g.	PROPN
admet-258	353	11	ohlenbusch	ohlenbusch	PROPN
admet-258	353	12	,	,	PUNCT
admet-258	353	13	t.	t.	PROPN
admet-258	353	14	lavé	lavé	NOUN
admet-258	353	15	,	,	PUNCT
admet-258	353	16	clinical	clinical	ADJ
admet-258	353	17	pharmacokinetics	pharmacokinetic	NOUN
admet-258	353	18	45(12	45(12	NUM
admet-258	353	19	)	)	PUNCT
admet-258	353	20	(	(	PUNCT
admet-258	353	21	2006	2006	NUM
admet-258	353	22	)	)	PUNCT
admet-258	353	23	1213	1213	NUM
admet-258	353	24	-	-	SYM
admet-258	353	25	1226	1226	NUM
admet-258	353	26	.	.	PUNCT
admet-258	354	1	[	[	X
admet-258	354	2	6	6	NUM
admet-258	354	3	]	]	X
admet-258	354	4	y.	y.	PROPN
admet-258	354	5	gao	gao	PROPN
admet-258	354	6	,	,	PUNCT
admet-258	354	7	r.a	r.a	PROPN
admet-258	354	8	.	.	PROPN
admet-258	354	9	carr	carr	PROPN
admet-258	354	10	,	,	PUNCT
admet-258	354	11	j.k	j.k	PROPN
admet-258	354	12	.	.	PROPN
admet-258	354	13	spence	spence	PROPN
admet-258	354	14	,	,	PUNCT
admet-258	354	15	w.w	w.w	PROPN
admet-258	354	16	.	.	PROPN
admet-258	354	17	wang	wang	PROPN
admet-258	354	18	,	,	PUNCT
admet-258	354	19	t.m	t.m	PROPN
admet-258	354	20	.	.	PROPN
admet-258	354	21	turner	turner	PROPN
admet-258	354	22	,	,	PUNCT
admet-258	354	23	j.m	j.m	PROPN
admet-258	354	24	.	.	PROPN
admet-258	354	25	lipari	lipari	PROPN
admet-258	354	26	,	,	PUNCT
admet-258	354	27	j.m	j.m	PROPN
admet-258	354	28	.	.	PROPN
admet-258	354	29	miller	miller	PROPN
admet-258	354	30	,	,	PUNCT
admet-258	354	31	molecular	molecular	ADJ
admet-258	354	32	pharmaceutics	pharmaceutic	NOUN
admet-258	354	33	7(5	7(5	NUM
admet-258	354	34	)	)	PUNCT
admet-258	354	35	(	(	PUNCT
admet-258	354	36	2010	2010	NUM
admet-258	354	37	)	)	PUNCT
admet-258	354	38	1516	1516	NUM
admet-258	354	39	-	-	SYM
admet-258	354	40	1526	1526	NUM
admet-258	354	41	.	.	PUNCT
admet-258	355	1	[	[	X
admet-258	355	2	7	7	X
admet-258	355	3	]	]	PUNCT
admet-258	355	4	m.	m.	NOUN
admet-258	355	5	hagio	hagio	NOUN
admet-258	355	6	,	,	PUNCT
admet-258	355	7	m.	m.	NOUN
admet-258	355	8	matsumoto	matsumoto	PROPN
admet-258	355	9	,	,	PUNCT
admet-258	355	10	m.	m.	NOUN
admet-258	355	11	fukushima	fukushima	PROPN
admet-258	355	12	,	,	PUNCT
admet-258	355	13	h.	h.	PROPN
admet-258	355	14	hara	hara	PROPN
admet-258	355	15	,	,	PUNCT
admet-258	355	16	s.	s.	PROPN
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admet-258	355	18	,	,	PUNCT
admet-258	355	19	journal	journal	NOUN
admet-258	355	20	of	of	ADP
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admet-258	355	22	research	research	PROPN
admet-258	355	23	50(1	50(1	PROPN
admet-258	355	24	)	)	PUNCT
admet-258	355	25	(	(	PUNCT
admet-258	355	26	2009	2009	NUM
admet-258	355	27	)	)	PUNCT
admet-258	355	28	173	173	NUM
admet-258	355	29	-	-	SYM
admet-258	355	30	180	180	NUM
admet-258	355	31	.	.	PUNCT
admet-258	356	1	[	[	X
admet-258	356	2	8	8	X
admet-258	356	3	]	]	X
admet-258	356	4	j.	j.	PROPN
admet-258	356	5	m.	m.	PROPN
admet-258	356	6	dietschy	dietschy	PROPN
admet-258	356	7	,	,	PUNCT
admet-258	356	8	journal	journal	NOUN
admet-258	356	9	of	of	ADP
admet-258	356	10	lipid	lipid	PROPN
admet-258	356	11	research	research	PROPN
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admet-258	356	13	)	)	PUNCT
admet-258	356	14	(	(	PUNCT
admet-258	356	15	1968	1968	NUM
admet-258	356	16	)	)	PUNCT
admet-258	356	17	297	297	NUM
admet-258	356	18	-	-	SYM
admet-258	356	19	309	309	NUM
admet-258	356	20	.	.	PUNCT
admet-258	357	1	[	[	X
admet-258	357	2	9	9	NUM
admet-258	357	3	]	]	X
admet-258	357	4	y.	y.	PROPN
admet-258	357	5	tanaka	tanaka	PROPN
admet-258	357	6	,	,	PUNCT
admet-258	357	7	t.	t.	PROPN
admet-258	357	8	hara	hara	PROPN
admet-258	357	9	,	,	PUNCT
admet-258	357	10	w.	w.	PROPN
admet-258	357	11	ryoichi	ryoichi	PROPN
admet-258	357	12	,	,	PUNCT
admet-258	357	13	n.	n.	PROPN
admet-258	357	14	shunji	shunji	PROPN
admet-258	357	15	,	,	PUNCT
admet-258	357	16	journal	journal	NOUN
admet-258	357	17	of	of	ADP
admet-258	357	18	pharmacy	pharmacy	PROPN
admet-258	357	19	&	&	CCONJ
admet-258	357	20	pharmaceutical	pharmaceutical	NOUN
admet-258	357	21	sciences	science	NOUN
admet-258	357	22	15(4	15(4	NOUN
admet-258	357	23	)	)	PUNCT
admet-258	357	24	(	(	PUNCT
admet-258	357	25	2012	2012	NUM
admet-258	357	26	)	)	PUNCT
admet-258	357	27	,	,	PUNCT
admet-258	357	28	510	510	NUM
admet-258	357	29	-	-	SYM
admet-258	357	30	518	518	NUM
admet-258	357	31	.	.	PUNCT
admet-258	358	1	[	[	X
admet-258	358	2	10	10	NUM
admet-258	358	3	]	]	X
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admet-258	358	5	musther	musther	PROPN
admet-258	358	6	,	,	PUNCT
admet-258	358	7	a.	a.	PROPN
admet-258	358	8	olivares	olivare	NOUN
admet-258	358	9	-	-	PUNCT
admet-258	358	10	morales	morale	NOUN
admet-258	358	11	,	,	PUNCT
admet-258	358	12	o.j	o.j	PROPN
admet-258	358	13	.	.	PROPN
admet-258	358	14	hatley	hatley	PROPN
admet-258	358	15	,	,	PUNCT
admet-258	358	16	b.	b.	PROPN
admet-258	358	17	liu	liu	PROPN
admet-258	358	18	,	,	PUNCT
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admet-258	358	21	hodjegan	hodjegan	PROPN
admet-258	358	22	,	,	PUNCT
admet-258	358	23	european	european	PROPN
admet-258	358	24	journal	journal	PROPN
admet-258	358	25	of	of	ADP
admet-258	358	26	pharmaceutical	pharmaceutical	PROPN
admet-258	358	27	sciences	science	NOUN
admet-258	358	28	57	57	NUM
admet-258	358	29	(	(	PUNCT
admet-258	358	30	2014	2014	NUM
admet-258	358	31	)	)	PUNCT
admet-258	358	32	280	280	NUM
admet-258	358	33	-	-	SYM
admet-258	358	34	291	291	NUM
admet-258	358	35	.	.	PUNCT
admet-258	359	1	[	[	X
admet-258	359	2	11	11	NUM
admet-258	359	3	]	]	PUNCT
admet-258	359	4	m.	m.	NOUN
admet-258	359	5	arndt	arndt	PROPN
admet-258	359	6	,	,	PUNCT
admet-258	359	7	h.	h.	PROPN
admet-258	359	8	chokshi	chokshi	PROPN
admet-258	359	9	,	,	PUNCT
admet-258	359	10	k.	k.	PROPN
admet-258	359	11	tang	tang	PROPN
admet-258	359	12	,	,	PUNCT
admet-258	359	13	n.j	n.j	PROPN
admet-258	359	14	.	.	PROPN
admet-258	359	15	parrott	parrott	PROPN
admet-258	359	16	,	,	PUNCT
admet-258	359	17	c.	c.	PROPN
admet-258	359	18	reppas	reppas	PROPN
admet-258	359	19	,	,	PUNCT
admet-258	360	1	j.b	j.b	PROPN
admet-258	360	2	.	.	PROPN
admet-258	360	3	dressman	dressman	PROPN
admet-258	360	4	,	,	PUNCT
admet-258	360	5	european	european	PROPN
admet-258	360	6	journal	journal	PROPN
admet-258	360	7	of	of	ADP
admet-258	360	8	pharmaceutics	pharmaceutic	NOUN
admet-258	360	9	and	and	CCONJ
admet-258	360	10	biopharmaceutics	biopharmaceutic	NOUN
admet-258	360	11	84(3	84(3	NUM
admet-258	360	12	)	)	PUNCT
admet-258	360	13	(	(	PUNCT
admet-258	360	14	2013	2013	NUM
admet-258	360	15	)	)	PUNCT
admet-258	360	16	633	633	NUM
admet-258	360	17	-	-	SYM
admet-258	360	18	641	641	NUM
admet-258	360	19	.	.	PUNCT
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admet-258	361	2	12	12	NUM
admet-258	361	3	]	]	X
admet-258	361	4	n.	n.	PROPN
admet-258	361	5	parrott	parrott	PROPN
admet-258	361	6	,	,	PUNCT
admet-258	361	7	n.	n.	PROPN
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admet-258	361	9	,	,	PUNCT
admet-258	361	10	p.	p.	NOUN
admet-258	361	11	coassolo	coassolo	PROPN
admet-258	361	12	,	,	PUNCT
admet-258	361	13	t.	t.	PROPN
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admet-258	361	18	pharmaceutical	pharmaceutical	ADJ
admet-258	361	19	sciences	science	NOUN
admet-258	361	20	94(10	94(10	NUM
admet-258	361	21	)	)	PUNCT
admet-258	361	22	(	(	PUNCT
admet-258	361	23	2005	2005	NUM
admet-258	361	24	)	)	PUNCT
admet-258	361	25	2327	2327	NUM
admet-258	361	26	-	-	SYM
admet-258	361	27	2343	2343	NUM
admet-258	361	28	.	.	PUNCT
admet-258	362	1	[	[	X
admet-258	362	2	13	13	NUM
admet-258	362	3	]	]	X
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admet-258	362	6	,	,	PUNCT
admet-258	362	7	b.	b.	PROPN
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admet-258	362	9	,	,	PUNCT
admet-258	362	10	journal	journal	NOUN
admet-258	362	11	of	of	ADP
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admet-258	362	13	chemistry	chemistry	NOUN
admet-258	362	14	44(6	44(6	NOUN
admet-258	362	15	)	)	PUNCT
admet-258	362	16	(	(	PUNCT
admet-258	362	17	2001	2001	NUM
admet-258	362	18	)	)	PUNCT
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admet-258	362	20	-	-	SYM
admet-258	362	21	930	930	NUM
admet-258	362	22	.	.	PUNCT
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admet-258	363	2	14	14	NUM
admet-258	363	3	]	]	X
admet-258	363	4	e.	e.	PROPN
admet-258	363	5	jantratid	jantratid	PROPN
admet-258	363	6	,	,	PUNCT
admet-258	363	7	n.	n.	PROPN
admet-258	363	8	janssen	janssen	PROPN
admet-258	363	9	,	,	PUNCT
admet-258	363	10	c.	c.	PROPN
admet-258	363	11	reppas	reppas	PROPN
admet-258	363	12	,	,	PUNCT
admet-258	363	13	j.b	j.b	PROPN
admet-258	363	14	.	.	PROPN
admet-258	363	15	dressman	dressman	PROPN
admet-258	363	16	,	,	PUNCT
admet-258	363	17	pharmaceutical	pharmaceutical	ADJ
admet-258	363	18	research	research	NOUN
admet-258	363	19	25(7	25(7	NUM
admet-258	363	20	)	)	PUNCT
admet-258	363	21	(	(	PUNCT
admet-258	363	22	2008	2008	NUM
admet-258	363	23	)	)	PUNCT
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admet-258	363	25	-	-	SYM
admet-258	363	26	1676	1676	NUM
admet-258	363	27	.	.	PUNCT
admet-258	364	1	[	[	X
admet-258	364	2	15	15	NUM
admet-258	364	3	]	]	X
admet-258	364	4	k.	k.	NOUN
admet-258	364	5	magwedere	magwedere	PROPN
admet-258	364	6	,	,	PUNCT
admet-258	364	7	s.	s.	PROPN
admet-258	364	8	mukaratirwa	mukaratirwa	PROPN
admet-258	364	9	,	,	PUNCT
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admet-258	364	11	journal	journal	NOUN
admet-258	364	12	of	of	ADP
admet-258	364	13	applied	apply	VERB
admet-258	364	14	research	research	NOUN
admet-258	364	15	in	in	ADP
admet-258	364	16	veterinary	veterinary	ADJ
admet-258	364	17	medicine	medicine	NOUN
admet-258	364	18	6(3	6(3	NUM
admet-258	364	19	)	)	PUNCT
admet-258	364	20	(	(	PUNCT
admet-258	364	21	2008	2008	NUM
admet-258	364	22	)	)	PUNCT
admet-258	364	23	166	166	NUM
admet-258	364	24	-	-	SYM
admet-258	364	25	174	174	NUM
admet-258	364	26	.	.	PUNCT
admet-258	365	1	[	[	X
admet-258	365	2	16	16	NUM
admet-258	365	3	]	]	X
admet-258	365	4	j.m	j.m	PROPN
admet-258	365	5	.	.	PROPN
admet-258	365	6	desesso	desesso	PROPN
admet-258	365	7	,	,	PUNCT
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admet-258	365	9	.	.	PROPN
admet-258	365	10	williams	williams	PROPN
admet-258	365	11	,	,	PUNCT
admet-258	365	12	annual	annual	ADJ
admet-258	365	13	reports	report	NOUN
admet-258	365	14	in	in	ADP
admet-258	365	15	medicinal	medicinal	ADJ
admet-258	365	16	chemistry	chemistry	NOUN
admet-258	365	17	43	43	NUM
admet-258	365	18	(	(	PUNCT
admet-258	365	19	2008	2008	NUM
admet-258	365	20	)	)	PUNCT
admet-258	365	21	353	353	NUM
admet-258	365	22	-	-	SYM
admet-258	365	23	371	371	NUM
admet-258	365	24	.	.	PUNCT
admet-258	366	1	[	[	X
admet-258	366	2	17	17	NUM
admet-258	366	3	]	]	X
admet-258	366	4	t.t	t.t	PROPN
admet-258	366	5	.	.	PROPN
admet-258	366	6	kararli	kararli	PROPN
admet-258	366	7	,	,	PUNCT
admet-258	366	8	biopharmaceutics	biopharmaceutics	PROPN
admet-258	366	9	&	&	CCONJ
admet-258	366	10	drug	drug	PROPN
admet-258	366	11	disposition	disposition	NOUN
admet-258	366	12	16	16	NUM
admet-258	366	13	(	(	PUNCT
admet-258	366	14	1995	1995	NUM
admet-258	366	15	)	)	PUNCT
admet-258	366	16	351	351	NUM
admet-258	366	17	-	-	SYM
admet-258	366	18	380	380	NUM
admet-258	366	19	.	.	PUNCT
admet-258	367	1	[	[	X
admet-258	367	2	18	18	NUM
admet-258	367	3	]	]	X
admet-258	367	4	d.m	d.m	PROPN
admet-258	367	5	.	.	PROPN
admet-258	367	6	heuman	heuman	PROPN
admet-258	367	7	,	,	PUNCT
admet-258	367	8	z.r	z.r	PROPN
admet-258	367	9	.	.	PROPN
admet-258	367	10	vlahcevic	vlahcevic	PROPN
admet-258	367	11	,	,	PUNCT
admet-258	367	12	m.l	m.l	PROPN
admet-258	367	13	.	.	PROPN
admet-258	367	14	bailey	bailey	PROPN
admet-258	367	15	,	,	PUNCT
admet-258	367	16	p.b	p.b	PROPN
admet-258	367	17	.	.	PROPN
admet-258	367	18	hylemon	hylemon	PROPN
admet-258	367	19	,	,	PUNCT
admet-258	367	20	hepatology	hepatology	NOUN
admet-258	367	21	8(4	8(4	NOUN
admet-258	367	22	)	)	PUNCT
admet-258	367	23	(	(	PUNCT
admet-258	367	24	1988	1988	NUM
admet-258	367	25	)	)	PUNCT
admet-258	367	26	892	892	NUM
admet-258	367	27	-	-	SYM
admet-258	367	28	897	897	NUM
admet-258	367	29	.	.	PUNCT
admet-258	367	30	admet	admet	PROPN
admet-258	367	31	&	&	CCONJ
admet-258	367	32	dmpk	dmpk	PROPN
admet-258	367	33	4(1	4(1	NOUN
admet-258	367	34	)	)	PUNCT
admet-258	367	35	(	(	PUNCT
admet-258	367	36	2016	2016	NUM
admet-258	367	37	)	)	PUNCT
admet-258	367	38	35	35	NUM
admet-258	367	39	-	-	SYM
admet-258	367	40	53	53	NUM
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admet-258	367	42	rat	rat	NOUN
admet-258	367	43	intestinal	intestinal	ADJ
admet-258	367	44	fluid	fluid	ADJ
admet-258	367	45	doi	doi	NOUN
admet-258	367	46	:	:	PUNCT
admet-258	367	47	10.5599	10.5599	NUM
admet-258	367	48	/	/	SYM
admet-258	367	49	admet.4.1.258	admet.4.1.258	PROPN
admet-258	367	50	53	53	NUM
admet-258	367	51	[	[	X
admet-258	367	52	19	19	NUM
admet-258	367	53	]	]	X
admet-258	367	54	h.a	h.a	PROPN
admet-258	367	55	.	.	PROPN
admet-258	367	56	merchant	merchant	PROPN
admet-258	367	57	,	,	PUNCT
admet-258	367	58	s.c	s.c	PROPN
admet-258	367	59	.	.	PROPN
admet-258	367	60	rabbie	rabbie	PROPN
admet-258	367	61	,	,	PUNCT
admet-258	367	62	f.j.o	f.j.o	PROPN
admet-258	367	63	.	.	PUNCT
admet-258	368	1	varum	varum	PROPN
admet-258	368	2	,	,	PUNCT
admet-258	368	3	f.	f.	PROPN
admet-258	368	4	afonso	afonso	PROPN
admet-258	368	5	-	-	PUNCT
admet-258	368	6	pereira	pereira	PROPN
admet-258	368	7	,	,	PUNCT
admet-258	368	8	a.w	a.w	PROPN
admet-258	368	9	.	.	PROPN
admet-258	368	10	basit	basit	PROPN
admet-258	368	11	,	,	PUNCT
admet-258	368	12	european	european	PROPN
admet-258	368	13	journal	journal	PROPN
admet-258	368	14	of	of	ADP
admet-258	368	15	pharmaceutical	pharmaceutical	PROPN
admet-258	368	16	sciences	science	NOUN
admet-258	368	17	62	62	NUM
admet-258	368	18	(	(	PUNCT
admet-258	368	19	2014	2014	NUM
admet-258	368	20	)	)	PUNCT
admet-258	368	21	76	76	NUM
admet-258	368	22	-	-	SYM
admet-258	368	23	85	85	NUM
admet-258	368	24	.	.	PUNCT
admet-258	369	1	[	[	X
admet-258	369	2	20	20	NUM
admet-258	369	3	]	]	X
admet-258	369	4	s.d	s.d	PROPN
admet-258	369	5	mithani	mithani	NOUN
admet-258	369	6	,	,	PUNCT
admet-258	369	7	v.	v.	ADP
admet-258	369	8	bakatselou	bakatselou	PROPN
admet-258	369	9	,	,	PUNCT
admet-258	369	10	c.n	c.n	PROPN
admet-258	369	11	.	.	PROPN
admet-258	369	12	tenhoor	tenhoor	PROPN
admet-258	369	13	,	,	PUNCT
admet-258	369	14	j.	j.	PROPN
admet-258	369	15	b.	b.	PROPN
admet-258	369	16	dressman	dressman	PROPN
admet-258	369	17	,	,	PUNCT
admet-258	369	18	pharmaceutical	pharmaceutical	ADJ
admet-258	369	19	research	research	NOUN
admet-258	369	20	13(1	13(1	NUM
admet-258	369	21	)	)	PUNCT
admet-258	369	22	(	(	PUNCT
admet-258	369	23	1996	1996	NUM
admet-258	369	24	)	)	PUNCT
admet-258	369	25	163167	163167	NUM
admet-258	369	26	.	.	PUNCT
admet-258	370	1	[	[	X
admet-258	370	2	21	21	NUM
admet-258	370	3	]	]	X
admet-258	370	4	m.	m.	NOUN
admet-258	370	5	germani	germani	PROPN
admet-258	370	6	,	,	PUNCT
admet-258	370	7	p.	p.	PROPN
admet-258	370	8	crivori	crivori	PROPN
admet-258	370	9	,	,	PUNCT
admet-258	370	10	m.	m.	NOUN
admet-258	370	11	rocchetti	rocchetti	PROPN
admet-258	370	12	,	,	PUNCT
admet-258	370	13	p.s	p.s	PROPN
admet-258	370	14	.	.	PROPN
admet-258	370	15	burton	burton	PROPN
admet-258	370	16	,	,	PUNCT
admet-258	370	17	a.g	a.g	PROPN
admet-258	370	18	.	.	PROPN
admet-258	370	19	wilson	wilson	PROPN
admet-258	370	20	,	,	PUNCT
admet-258	370	21	m.e	m.e	PROPN
admet-258	370	22	.	.	PROPN
admet-258	370	23	smith	smith	PROPN
admet-258	370	24	,	,	PUNCT
admet-258	370	25	i.	i.	PROPN
admet-258	370	26	pogessi	pogessi	PROPN
admet-258	370	27	,	,	PUNCT
admet-258	370	28	european	european	PROPN
admet-258	370	29	journal	journal	PROPN
admet-258	370	30	of	of	ADP
admet-258	370	31	pharmaceutical	pharmaceutical	PROPN
admet-258	370	32	sciences	science	NOUN
admet-258	370	33	31	31	NUM
admet-258	370	34	(	(	PUNCT
admet-258	370	35	2007	2007	NUM
admet-258	370	36	)	)	PUNCT
admet-258	370	37	190	190	NUM
admet-258	370	38	-	-	PUNCT
admet-258	370	39	201	201	NUM
admet-258	370	40	.	.	PUNCT
admet-258	371	1	[	[	X
admet-258	371	2	22	22	NUM
admet-258	371	3	]	]	X
admet-258	371	4	h.	h.	PROPN
admet-258	371	5	m.	m.	PROPN
admet-258	371	6	jones	jones	PROPN
admet-258	371	7	,	,	PUNCT
admet-258	371	8	i.	i.	PROPN
admet-258	371	9	b.	b.	PROPN
admet-258	371	10	gardner	gardner	PROPN
admet-258	371	11	,	,	PUNCT
admet-258	371	12	k.	k.	PROPN
admet-258	371	13	j.	j.	PROPN
admet-258	371	14	watson	watson	PROPN
admet-258	371	15	,	,	PUNCT
admet-258	371	16	the	the	DET
admet-258	371	17	aaps	aap	NOUN
admet-258	371	18	journal	journal	PROPN
admet-258	371	19	11(1	11(1	NUM
admet-258	371	20	)	)	PUNCT
admet-258	371	21	(	(	PUNCT
admet-258	371	22	2009	2009	NUM
admet-258	371	23	)	)	PUNCT
admet-258	371	24	155	155	NUM
admet-258	371	25	-	-	SYM
admet-258	371	26	166	166	NUM
admet-258	371	27	.	.	PUNCT
admet-258	372	1	©	©	PROPN
admet-258	372	2	2016	2016	NUM
admet-258	372	3	by	by	ADP
admet-258	372	4	the	the	DET
admet-258	372	5	authors	author	NOUN
admet-258	372	6	;	;	PUNCT
admet-258	372	7	licensee	licensee	PROPN
admet-258	372	8	iapc	iapc	PROPN
admet-258	372	9	,	,	PUNCT
admet-258	372	10	zagreb	zagreb	PROPN
admet-258	372	11	,	,	PUNCT
admet-258	372	12	croatia	croatia	PROPN
admet-258	372	13	.	.	PUNCT
admet-258	373	1	this	this	DET
admet-258	373	2	article	article	NOUN
admet-258	373	3	is	be	AUX
admet-258	373	4	an	an	DET
admet-258	373	5	open	open	ADJ
admet-258	373	6	-	-	PUNCT
admet-258	373	7	access	access	NOUN
admet-258	373	8	article	article	NOUN
admet-258	373	9	distributed	distribute	VERB
admet-258	373	10	under	under	ADP
admet-258	373	11	the	the	DET
admet-258	373	12	terms	term	NOUN
admet-258	373	13	and	and	CCONJ
admet-258	373	14	conditions	condition	NOUN
admet-258	373	15	of	of	ADP
admet-258	373	16	the	the	DET
admet-258	373	17	creative	creative	ADJ
admet-258	373	18	commons	common	NOUN
admet-258	373	19	attribution	attribution	NOUN
admet-258	373	20	license	license	NOUN
admet-258	373	21	(	(	PUNCT
admet-258	373	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-258	373	23	)	)	PUNCT
admet-258	373	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN