id	sid	tid	token	lemma	pos
admet-2582	1	1	preclinical	preclinical	ADJ
admet-2582	1	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	1	3	,	,	PUNCT
admet-2582	1	4	distribution	distribution	NOUN
admet-2582	1	5	,	,	PUNCT
admet-2582	1	6	metabolism	metabolism	NOUN
admet-2582	1	7	and	and	CCONJ
admet-2582	1	8	excretion	excretion	NOUN
admet-2582	1	9	of	of	ADP
admet-2582	1	10	disitamab	disitamab	NOUN
admet-2582	1	11	vedotin	vedotin	ADJ
admet-2582	1	12	doi	doi	NOUN
admet-2582	1	13	:	:	PUNCT
admet-2582	1	14	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	1	15	1	1	NUM
admet-2582	1	16	admet	admet	X
admet-2582	1	17	&	&	CCONJ
admet-2582	1	18	dmpk	dmpk	PROPN
admet-2582	1	19	13(2	13(2	PROPN
admet-2582	1	20	)	)	PUNCT
admet-2582	1	21	(	(	PUNCT
admet-2582	1	22	2025	2025	NUM
admet-2582	1	23	)	)	PUNCT
admet-2582	1	24	2582	2582	NUM
admet-2582	1	25	;	;	PUNCT
admet-2582	1	26	doi	doi	NOUN
admet-2582	1	27	:	:	PUNCT
admet-2582	1	28	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	1	29	open	open	ADJ
admet-2582	1	30	access	access	NOUN
admet-2582	1	31	:	:	PUNCT
admet-2582	1	32	issn	issn	PROPN
admet-2582	1	33	:	:	PUNCT
admet-2582	1	34	1848	1848	NUM
admet-2582	1	35	-	-	SYM
admet-2582	1	36	7718	7718	NUM
admet-2582	1	37	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2582	1	38	original	original	ADJ
admet-2582	1	39	scientific	scientific	ADJ
admet-2582	1	40	paper	paper	NOUN
admet-2582	1	41	preclinical	preclinical	ADJ
admet-2582	1	42	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	1	43	,	,	PUNCT
admet-2582	1	44	distribution	distribution	NOUN
admet-2582	1	45	,	,	PUNCT
admet-2582	1	46	metabolism	metabolism	NOUN
admet-2582	1	47	and	and	CCONJ
admet-2582	1	48	excretion	excretion	NOUN
admet-2582	1	49	of	of	ADP
admet-2582	1	50	disitamab	disitamab	NOUN
admet-2582	1	51	vedotin	vedotin	PROPN
admet-2582	1	52	ling	ling	PROPN
admet-2582	1	53	wang1,2	wang1,2	PROPN
admet-2582	1	54	,	,	PUNCT
admet-2582	1	55	limeng	limeng	PROPN
admet-2582	1	56	zhu1,2	zhu1,2	PROPN
admet-2582	1	57	,	,	PUNCT
admet-2582	1	58	fengzhu	fengzhu	PROPN
admet-2582	1	59	wang3	wang3	PROPN
admet-2582	1	60	,	,	PUNCT
admet-2582	1	61	lihou	lihou	PROPN
admet-2582	1	62	dong4	dong4	PROPN
admet-2582	1	63	,	,	PUNCT
admet-2582	1	64	zhihao	zhihao	PROPN
admet-2582	1	65	liu1,3	liu1,3	PROPN
admet-2582	1	66	,	,	PUNCT
admet-2582	1	67	fang	fang	X
admet-2582	1	68	chen4	chen4	NOUN
admet-2582	1	69	and	and	CCONJ
admet-2582	1	70	jing	je	VERB
admet-2582	1	71	jiang2,5	jiang2,5	PROPN
admet-2582	1	72	,	,	PUNCT
admet-2582	1	73	*	*	PROPN
admet-2582	1	74	1remegen	1remegen	NUM
admet-2582	1	75	co.	co.	PROPN
admet-2582	1	76	,	,	PUNCT
admet-2582	1	77	ltd	ltd	PROPN
admet-2582	1	78	,	,	PUNCT
admet-2582	1	79	yantai	yantai	PROPN
admet-2582	1	80	264000	264000	NUM
admet-2582	1	81	,	,	PUNCT
admet-2582	1	82	shandong	shandong	PROPN
admet-2582	1	83	,	,	PUNCT
admet-2582	1	84	china	china	PROPN
admet-2582	1	85	2rongchang	2rongchang	PROPN
admet-2582	1	86	industry	industry	NOUN
admet-2582	1	87	college	college	NOUN
admet-2582	1	88	,	,	PUNCT
admet-2582	1	89	264003	264003	NUM
admet-2582	1	90	,	,	PUNCT
admet-2582	1	91	shandong	shandong	PROPN
admet-2582	1	92	,	,	PUNCT
admet-2582	1	93	china	china	PROPN
admet-2582	1	94	3new	3new	PROPN
admet-2582	1	95	york	york	PROPN
admet-2582	1	96	university	university	PROPN
admet-2582	1	97	,	,	PUNCT
admet-2582	1	98	grossman	grossman	PROPN
admet-2582	1	99	school	school	NOUN
admet-2582	1	100	of	of	ADP
admet-2582	1	101	medicine	medicine	NOUN
admet-2582	1	102	,	,	PUNCT
admet-2582	1	103	new	new	PROPN
admet-2582	1	104	york	york	PROPN
admet-2582	1	105	,	,	PUNCT
admet-2582	1	106	ny	ny	PROPN
admet-2582	1	107	,	,	PUNCT
admet-2582	1	108	usa	usa	PROPN
admet-2582	1	109	4united	4united	PROPN
admet-2582	1	110	-	-	PUNCT
admet-2582	1	111	power	power	NOUN
admet-2582	1	112	pharma	pharma	PROPN
admet-2582	1	113	tech	tech	PROPN
admet-2582	1	114	co.	co.	PROPN
admet-2582	1	115	ltd	ltd	PROPN
admet-2582	1	116	,	,	PUNCT
admet-2582	1	117	beijing	beijing	PROPN
admet-2582	1	118	102206	102206	NUM
admet-2582	1	119	,	,	PUNCT
admet-2582	1	120	china	china	PROPN
admet-2582	1	121	5department	5department	NUM
admet-2582	1	122	of	of	ADP
admet-2582	1	123	pharmacology	pharmacology	NOUN
admet-2582	1	124	,	,	PUNCT
admet-2582	1	125	binzhou	binzhou	PROPN
admet-2582	1	126	medical	medical	ADJ
admet-2582	1	127	university	university	PROPN
admet-2582	1	128	,	,	PUNCT
admet-2582	1	129	yantai	yantai	PROPN
admet-2582	1	130	264003	264003	NUM
admet-2582	1	131	,	,	PUNCT
admet-2582	1	132	shandong	shandong	PROPN
admet-2582	1	133	,	,	PUNCT
admet-2582	1	134	china	china	PROPN
admet-2582	1	135	*	*	PUNCT
admet-2582	1	136	corresponding	correspond	VERB
admet-2582	1	137	author	author	NOUN
admet-2582	1	138	:	:	PUNCT
admet-2582	1	139	e	e	NOUN
admet-2582	1	140	-	-	NOUN
admet-2582	1	141	mail	mail	NOUN
admet-2582	1	142	:	:	PUNCT
admet-2582	1	143	jing_jiang1974@sina.com	jing_jiang1974@sina.com	PROPN
admet-2582	1	144	;	;	PUNCT
admet-2582	1	145	jjiang@bzmc.edu.cn	jjiang@bzmc.edu.cn	PROPN
admet-2582	1	146	received	receive	VERB
admet-2582	1	147	:	:	PUNCT
admet-2582	1	148	november	november	PROPN
admet-2582	1	149	10	10	NUM
admet-2582	1	150	,	,	PUNCT
admet-2582	1	151	2024	2024	NUM
admet-2582	1	152	;	;	PUNCT
admet-2582	1	153	revised	revise	VERB
admet-2582	1	154	:	:	PUNCT
admet-2582	1	155	february	february	PROPN
admet-2582	1	156	22	22	NUM
admet-2582	1	157	,	,	PUNCT
admet-2582	1	158	2025	2025	NUM
admet-2582	1	159	;	;	PUNCT
admet-2582	1	160	published	publish	VERB
admet-2582	1	161	:	:	PUNCT
admet-2582	1	162	march	march	PROPN
admet-2582	1	163	14	14	NUM
admet-2582	1	164	,	,	PUNCT
admet-2582	1	165	2025	2025	NUM
admet-2582	1	166	abstract	abstract	ADJ
admet-2582	1	167	background	background	NOUN
admet-2582	1	168	and	and	CCONJ
admet-2582	1	169	purpose	purpose	NOUN
admet-2582	1	170	:	:	PUNCT
admet-2582	1	171	disitamab	disitamab	NOUN
admet-2582	1	172	vedotin	vedotin	NOUN
admet-2582	1	173	is	be	AUX
admet-2582	1	174	an	an	DET
admet-2582	1	175	antibody	antibody	NOUN
admet-2582	1	176	-	-	PUNCT
admet-2582	1	177	drug	drug	NOUN
admet-2582	1	178	conjugate	conjugate	NOUN
admet-2582	1	179	(	(	PUNCT
admet-2582	1	180	adc	adc	PROPN
admet-2582	1	181	)	)	PUNCT
admet-2582	1	182	composed	compose	VERB
admet-2582	1	183	of	of	ADP
admet-2582	1	184	a	a	DET
admet-2582	1	185	humanized	humanize	VERB
admet-2582	1	186	igg1	igg1	NOUN
admet-2582	1	187	monoclonal	monoclonal	NOUN
admet-2582	1	188	antibody	antibody	NOUN
admet-2582	1	189	(	(	PUNCT
admet-2582	1	190	mab	mab	PROPN
admet-2582	1	191	)	)	PUNCT
admet-2582	1	192	targeting	target	VERB
admet-2582	1	193	her2	her2	NOUN
admet-2582	1	194	conjugated	conjugate	VERB
admet-2582	1	195	to	to	ADP
admet-2582	1	196	monomethyl	monomethyl	PROPN
admet-2582	1	197	auristatin	auristatin	PROPN
admet-2582	1	198	e(mmae	e(mmae	NOUN
admet-2582	1	199	)	)	PUNCT
admet-2582	1	200	via	via	ADP
admet-2582	1	201	a	a	DET
admet-2582	1	202	cleavable	cleavable	ADJ
admet-2582	1	203	dipeptide	dipeptide	NOUN
admet-2582	1	204	linker	linker	NOUN
admet-2582	1	205	.	.	PUNCT
admet-2582	2	1	experimental	experimental	ADJ
admet-2582	2	2	approach	approach	NOUN
admet-2582	2	3	:	:	PUNCT
admet-2582	2	4	the	the	DET
admet-2582	2	5	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	2	6	,	,	PUNCT
admet-2582	2	7	distribution	distribution	NOUN
admet-2582	2	8	,	,	PUNCT
admet-2582	2	9	catabolism	catabolism	NOUN
admet-2582	2	10	/	/	SYM
admet-2582	2	11	metabolism	metabolism	NOUN
admet-2582	2	12	and	and	CCONJ
admet-2582	2	13	elimination	elimination	NOUN
admet-2582	2	14	properties	property	NOUN
admet-2582	2	15	of	of	ADP
admet-2582	2	16	disitamab	disitamab	NOUN
admet-2582	2	17	vedotin	vedotin	ADJ
admet-2582	2	18	and	and	CCONJ
admet-2582	2	19	its	its	PRON
admet-2582	2	20	payload	payload	NOUN
admet-2582	2	21	mmae	mmae	NOUN
admet-2582	2	22	were	be	AUX
admet-2582	2	23	characterized	characterize	VERB
admet-2582	2	24	in	in	ADP
admet-2582	2	25	rats	rat	NOUN
admet-2582	2	26	and	and	CCONJ
admet-2582	2	27	tumour	tumour	NOUN
admet-2582	2	28	-	-	PUNCT
admet-2582	2	29	bearing	bear	VERB
admet-2582	2	30	mice	mouse	NOUN
admet-2582	2	31	.	.	PUNCT
admet-2582	3	1	key	key	ADJ
admet-2582	3	2	results	result	NOUN
admet-2582	3	3	:	:	PUNCT
admet-2582	3	4	the	the	DET
admet-2582	3	5	configured	configure	VERB
admet-2582	3	6	mab	mab	NOUN
admet-2582	3	7	and	and	CCONJ
admet-2582	3	8	total	total	ADJ
admet-2582	3	9	antibody	antibody	NOUN
admet-2582	3	10	showed	show	VERB
admet-2582	3	11	linear	linear	ADJ
admet-2582	3	12	dynamic	dynamic	ADJ
admet-2582	3	13	characteristics	characteristic	NOUN
admet-2582	3	14	.	.	PUNCT
admet-2582	4	1	moreover	moreover	ADV
admet-2582	4	2	,	,	PUNCT
admet-2582	4	3	the	the	DET
admet-2582	4	4	molecular	molecular	ADJ
admet-2582	4	5	structure	structure	NOUN
admet-2582	4	6	of	of	ADP
admet-2582	4	7	disitamab	disitamab	NOUN
admet-2582	4	8	vedotin	vedotin	PROPN
admet-2582	4	9	effectively	effectively	ADV
admet-2582	4	10	reduces	reduce	VERB
admet-2582	4	11	the	the	DET
admet-2582	4	12	exposure	exposure	NOUN
admet-2582	4	13	of	of	ADP
admet-2582	4	14	mmae	mmae	NOUN
admet-2582	4	15	,	,	PUNCT
admet-2582	4	16	which	which	PRON
admet-2582	4	17	has	have	VERB
admet-2582	4	18	a	a	DET
admet-2582	4	19	fast	fast	ADJ
admet-2582	4	20	clearance	clearance	NOUN
admet-2582	4	21	.	.	PUNCT
admet-2582	5	1	two	two	NUM
admet-2582	5	2	radiolabeled	radiolabele	VERB
admet-2582	5	3	probes	probe	NOUN
admet-2582	5	4	were	be	AUX
admet-2582	5	5	developed	develop	VERB
admet-2582	5	6	to	to	PART
admet-2582	5	7	track	track	VERB
admet-2582	5	8	the	the	DET
admet-2582	5	9	fate	fate	NOUN
admet-2582	5	10	of	of	ADP
admet-2582	5	11	different	different	ADJ
admet-2582	5	12	components	component	NOUN
admet-2582	5	13	of	of	ADP
admet-2582	5	14	the	the	DET
admet-2582	5	15	disitamab	disitamab	NOUN
admet-2582	5	16	vedotin	vedotin	NOUN
admet-2582	5	17	,	,	PUNCT
admet-2582	5	18	including	include	VERB
admet-2582	5	19	125i	125i	NOUN
admet-2582	5	20	labelled	label	VERB
admet-2582	5	21	antibody	antibody	NOUN
admet-2582	5	22	and	and	CCONJ
admet-2582	5	23	3h	3h	NUM
admet-2582	5	24	labelled	label	VERB
admet-2582	5	25	mmae	mmae	NOUN
admet-2582	5	26	payload	payload	NOUN
admet-2582	5	27	of	of	ADP
admet-2582	5	28	the	the	DET
admet-2582	5	29	adc	adc	PROPN
admet-2582	5	30	.	.	PUNCT
admet-2582	6	1	following	follow	VERB
admet-2582	6	2	a	a	DET
admet-2582	6	3	single	single	ADJ
admet-2582	6	4	intravenous	intravenous	ADJ
admet-2582	6	5	administration	administration	NOUN
admet-2582	6	6	of	of	ADP
admet-2582	6	7	the	the	DET
admet-2582	6	8	radiolabeled	radiolabele	VERB
admet-2582	6	9	probes	probe	NOUN
admet-2582	6	10	to	to	ADP
admet-2582	6	11	the	the	DET
admet-2582	6	12	tumour	tumour	NOUN
admet-2582	6	13	-	-	PUNCT
admet-2582	6	14	bearing	bear	VERB
admet-2582	6	15	mice	mouse	NOUN
admet-2582	6	16	and	and	CCONJ
admet-2582	6	17	rats	rat	NOUN
admet-2582	6	18	,	,	PUNCT
admet-2582	6	19	blood	blood	NOUN
admet-2582	6	20	,	,	PUNCT
admet-2582	6	21	various	various	ADJ
admet-2582	6	22	tissues	tissue	NOUN
admet-2582	6	23	,	,	PUNCT
admet-2582	6	24	and	and	CCONJ
admet-2582	6	25	excreta	excreta	NOUN
admet-2582	6	26	samples	sample	NOUN
admet-2582	6	27	were	be	AUX
admet-2582	6	28	collected	collect	VERB
admet-2582	6	29	and	and	CCONJ
admet-2582	6	30	analyzed	analyze	VERB
admet-2582	6	31	for	for	ADP
admet-2582	6	32	radioactivity	radioactivity	NOUN
admet-2582	6	33	and	and	CCONJ
admet-2582	6	34	to	to	PART
admet-2582	6	35	characterize	characterize	VERB
admet-2582	6	36	the	the	DET
admet-2582	6	37	metabolites	metabolite	NOUN
admet-2582	6	38	/	/	SYM
admet-2582	6	39	catabolites	catabolite	NOUN
admet-2582	6	40	.	.	PUNCT
admet-2582	7	1	disitamab	disitamab	NOUN
admet-2582	7	2	vedotin	vedotin	ADJ
admet-2582	7	3	and	and	CCONJ
admet-2582	7	4	free	free	ADJ
admet-2582	7	5	mmae	mmae	NOUN
admet-2582	7	6	(	(	PUNCT
admet-2582	7	7	fm	fm	NOUN
admet-2582	7	8	)	)	PUNCT
admet-2582	7	9	were	be	AUX
admet-2582	7	10	majorly	majorly	ADV
admet-2582	7	11	distributed	distribute	VERB
admet-2582	7	12	in	in	ADP
admet-2582	7	13	tissues	tissue	NOUN
admet-2582	7	14	and	and	CCONJ
admet-2582	7	15	organs	organ	NOUN
admet-2582	7	16	with	with	ADP
admet-2582	7	17	rich	rich	ADJ
admet-2582	7	18	blood	blood	NOUN
admet-2582	7	19	flow	flow	NOUN
admet-2582	7	20	.	.	PUNCT
admet-2582	8	1	moreover	moreover	ADV
admet-2582	8	2	,	,	PUNCT
admet-2582	8	3	both	both	PRON
admet-2582	8	4	disitamab	disitamab	VERB
admet-2582	8	5	vedotin	vedotin	ADV
admet-2582	8	6	and	and	CCONJ
admet-2582	8	7	mmae	mmae	NOUN
admet-2582	8	8	have	have	VERB
admet-2582	8	9	higher	high	ADJ
admet-2582	8	10	and	and	CCONJ
admet-2582	8	11	longer	long	ADJ
admet-2582	8	12	exposure	exposure	NOUN
admet-2582	8	13	in	in	ADP
admet-2582	8	14	tumour	tumour	ADJ
admet-2582	8	15	tissue	tissue	NOUN
admet-2582	8	16	.	.	PUNCT
admet-2582	9	1	disitamab	disitamab	NOUN
admet-2582	9	2	vedotin	vedotin	PROPN
admet-2582	9	3	was	be	AUX
admet-2582	9	4	mainly	mainly	ADV
admet-2582	9	5	eliminated	eliminate	VERB
admet-2582	9	6	through	through	ADP
admet-2582	9	7	renal	renal	ADJ
admet-2582	9	8	excretion	excretion	NOUN
admet-2582	9	9	,	,	PUNCT
admet-2582	9	10	while	while	SCONJ
admet-2582	9	11	the	the	DET
admet-2582	9	12	fm	fm	NOUN
admet-2582	9	13	was	be	AUX
admet-2582	9	14	mainly	mainly	ADV
admet-2582	9	15	eliminated	eliminate	VERB
admet-2582	9	16	through	through	ADP
admet-2582	9	17	the	the	DET
admet-2582	9	18	biliary	biliary	ADJ
admet-2582	9	19	faecal	faecal	ADJ
admet-2582	9	20	route	route	NOUN
admet-2582	9	21	(	(	PUNCT
admet-2582	9	22	>	>	X
admet-2582	9	23	70	70	NUM
admet-2582	9	24	%	%	NOUN
admet-2582	9	25	)	)	PUNCT
admet-2582	9	26	and	and	CCONJ
admet-2582	9	27	a	a	DET
admet-2582	9	28	small	small	ADJ
admet-2582	9	29	fraction	fraction	NOUN
admet-2582	9	30	(	(	PUNCT
admet-2582	9	31	<	<	X
admet-2582	9	32	10	10	NUM
admet-2582	9	33	%	%	NOUN
admet-2582	9	34	)	)	PUNCT
admet-2582	9	35	was	be	AUX
admet-2582	9	36	eliminated	eliminate	VERB
admet-2582	9	37	through	through	ADP
admet-2582	9	38	renal	renal	ADJ
admet-2582	9	39	excretion	excretion	NOUN
admet-2582	9	40	in	in	ADP
admet-2582	9	41	the	the	DET
admet-2582	9	42	form	form	NOUN
admet-2582	9	43	of	of	ADP
admet-2582	9	44	catabolites	catabolite	NOUN
admet-2582	9	45	/	/	SYM
admet-2582	9	46	metabolites	metabolite	NOUN
admet-2582	9	47	,	,	PUNCT
admet-2582	9	48	among	among	ADP
admet-2582	9	49	which	which	PRON
admet-2582	9	50	,	,	PUNCT
admet-2582	9	51	mmae	mmae	PROPN
admet-2582	9	52	was	be	AUX
admet-2582	9	53	identified	identify	VERB
admet-2582	9	54	as	as	ADP
admet-2582	9	55	the	the	DET
admet-2582	9	56	major	major	ADJ
admet-2582	9	57	species	specie	NOUN
admet-2582	9	58	,	,	PUNCT
admet-2582	9	59	along	along	ADP
admet-2582	9	60	with	with	ADP
admet-2582	9	61	10	10	NUM
admet-2582	9	62	other	other	ADJ
admet-2582	9	63	minor	minor	ADJ
admet-2582	9	64	species	specie	NOUN
admet-2582	9	65	.	.	PUNCT
admet-2582	10	1	conclusion	conclusion	NOUN
admet-2582	10	2	:	:	PUNCT
admet-2582	10	3	these	these	DET
admet-2582	10	4	studies	study	NOUN
admet-2582	10	5	provided	provide	VERB
admet-2582	10	6	significant	significant	ADJ
admet-2582	10	7	insight	insight	NOUN
admet-2582	10	8	into	into	ADP
admet-2582	10	9	disitamab	disitamab	NOUN
admet-2582	10	10	vedotin	vedotin	NOUN
admet-2582	10	11	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	10	12	,	,	PUNCT
admet-2582	10	13	distribution	distribution	NOUN
admet-2582	10	14	,	,	PUNCT
admet-2582	10	15	metabolism	metabolism	NOUN
admet-2582	10	16	and	and	CCONJ
admet-2582	10	17	elimination	elimination	NOUN
admet-2582	10	18	properties	property	NOUN
admet-2582	10	19	,	,	PUNCT
admet-2582	10	20	which	which	PRON
admet-2582	10	21	supports	support	VERB
admet-2582	10	22	the	the	DET
admet-2582	10	23	clinical	clinical	ADJ
admet-2582	10	24	development	development	NOUN
admet-2582	10	25	of	of	ADP
admet-2582	10	26	disitamab	disitamab	NOUN
admet-2582	10	27	vedotin	vedotin	ADJ
admet-2582	10	28	.	.	PUNCT
admet-2582	11	1	©	©	PROPN
admet-2582	11	2	2025	2025	NUM
admet-2582	11	3	by	by	ADP
admet-2582	11	4	the	the	DET
admet-2582	11	5	authors	author	NOUN
admet-2582	11	6	.	.	PUNCT
admet-2582	12	1	this	this	DET
admet-2582	12	2	article	article	NOUN
admet-2582	12	3	is	be	AUX
admet-2582	12	4	an	an	DET
admet-2582	12	5	open	open	ADJ
admet-2582	12	6	-	-	PUNCT
admet-2582	12	7	access	access	NOUN
admet-2582	12	8	article	article	NOUN
admet-2582	12	9	distributed	distribute	VERB
admet-2582	12	10	under	under	ADP
admet-2582	12	11	the	the	DET
admet-2582	12	12	terms	term	NOUN
admet-2582	12	13	and	and	CCONJ
admet-2582	12	14	conditions	condition	NOUN
admet-2582	12	15	of	of	ADP
admet-2582	12	16	the	the	DET
admet-2582	12	17	creative	creative	ADJ
admet-2582	12	18	commons	common	NOUN
admet-2582	12	19	attribution	attribution	NOUN
admet-2582	12	20	license	license	NOUN
admet-2582	12	21	(	(	PUNCT
admet-2582	12	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2582	12	23	)	)	PUNCT
admet-2582	12	24	.	.	PUNCT
admet-2582	13	1	keywords	keyword	VERB
admet-2582	13	2	antibody	antibody	NOUN
admet-2582	13	3	-	-	PUNCT
admet-2582	13	4	drug	drug	NOUN
admet-2582	13	5	conjugate	conjugate	NOUN
admet-2582	13	6	;	;	PUNCT
admet-2582	13	7	physiological	physiological	ADJ
admet-2582	13	8	disposition	disposition	NOUN
admet-2582	13	9	;	;	PUNCT
admet-2582	13	10	monomethyl	monomethyl	PROPN
admet-2582	13	11	auristatin	auristatin	PROPN
admet-2582	13	12	e	e	PROPN
admet-2582	13	13	(	(	PUNCT
admet-2582	13	14	mmae	mmae	PROPN
admet-2582	13	15	)	)	PUNCT
admet-2582	13	16	;	;	PUNCT
admet-2582	13	17	mass	mass	NOUN
admet-2582	13	18	balance	balance	NOUN
admet-2582	13	19	introduction	introduction	NOUN
admet-2582	13	20	antibody	antibody	NOUN
admet-2582	13	21	-	-	PUNCT
admet-2582	13	22	conjugated	conjugate	VERB
admet-2582	13	23	drugs	drug	NOUN
admet-2582	13	24	(	(	PUNCT
admet-2582	13	25	adc	adc	PROPN
admet-2582	13	26	)	)	PUNCT
admet-2582	13	27	are	be	AUX
admet-2582	13	28	effective	effective	ADJ
admet-2582	13	29	antitumor	antitumor	NOUN
admet-2582	13	30	drugs	drug	NOUN
admet-2582	13	31	conjugated	conjugate	VERB
admet-2582	13	32	by	by	ADP
admet-2582	13	33	monoclonal	monoclonal	NOUN
admet-2582	13	34	antibodies	antibody	NOUN
admet-2582	13	35	and	and	CCONJ
admet-2582	13	36	small	small	ADJ
admet-2582	13	37	molecule	molecule	NOUN
admet-2582	13	38	cytotoxic	cytotoxic	ADJ
admet-2582	13	39	loads	load	NOUN
admet-2582	13	40	through	through	ADP
admet-2582	13	41	a	a	DET
admet-2582	13	42	linker	linker	NOUN
admet-2582	13	43	.	.	PUNCT
admet-2582	14	1	adcs	adcs	PROPN
admet-2582	14	2	are	be	AUX
admet-2582	14	3	altering	alter	VERB
admet-2582	14	4	the	the	DET
admet-2582	14	5	modern	modern	ADJ
admet-2582	14	6	oncology	oncology	NOUN
admet-2582	14	7	landscape	landscape	NOUN
admet-2582	14	8	,	,	PUNCT
admet-2582	14	9	possessing	possess	VERB
admet-2582	14	10	both	both	CCONJ
admet-2582	14	11	the	the	DET
admet-2582	14	12	high	high	ADJ
admet-2582	14	13	targeting	targeting	NOUN
admet-2582	14	14	performance	performance	NOUN
admet-2582	14	15	of	of	ADP
admet-2582	14	16	monoclonal	monoclonal	NOUN
admet-2582	14	17	antibodies	antibody	NOUN
admet-2582	14	18	and	and	CCONJ
admet-2582	14	19	the	the	DET
admet-2582	14	20	powerful	powerful	ADJ
admet-2582	14	21	killing	killing	NOUN
admet-2582	14	22	effect	effect	NOUN
admet-2582	14	23	of	of	ADP
admet-2582	14	24	small	small	ADJ
admet-2582	14	25	molecule	molecule	NOUN
admet-2582	14	26	cytotoxic	cytotoxic	ADJ
admet-2582	14	27	drugs	drug	NOUN
admet-2582	14	28	[	[	X
admet-2582	14	29	1	1	NUM
admet-2582	14	30	]	]	PUNCT
admet-2582	14	31	.	.	PUNCT
admet-2582	15	1	meanwhile	meanwhile	ADV
admet-2582	15	2	,	,	PUNCT
admet-2582	15	3	the	the	DET
admet-2582	15	4	global	global	ADJ
admet-2582	15	5	sales	sale	NOUN
admet-2582	15	6	of	of	ADP
admet-2582	15	7	currently	currently	ADV
admet-2582	15	8	marketed	market	VERB
admet-2582	15	9	adcs	adc	NOUN
admet-2582	15	10	are	be	AUX
admet-2582	15	11	forecast	forecast	VERB
admet-2582	15	12	to	to	PART
admet-2582	15	13	exceed	exceed	VERB
admet-2582	15	14	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	15	15	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	15	16	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2582	15	17	mailto:jing_jiang1974@sina.com	mailto:jing_jiang1974@sina.com	X
admet-2582	15	18	mailto:jjiang@bzmc.edu.cn	mailto:jjiang@bzmc.edu.cn	PROPN
admet-2582	15	19	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2582	15	20	m.	m.	NOUN
admet-2582	15	21	das	das	PROPN
admet-2582	16	1	et	et	PROPN
admet-2582	16	2	al	al	PROPN
admet-2582	16	3	.	.	PROPN
admet-2582	16	4	admet	admet	PROPN
admet-2582	16	5	&	&	CCONJ
admet-2582	16	6	dmpk	dmpk	PROPN
admet-2582	16	7	13(2	13(2	PROPN
admet-2582	16	8	)	)	PUNCT
admet-2582	16	9	(	(	PUNCT
admet-2582	16	10	2025	2025	NUM
admet-2582	16	11	)	)	PUNCT
admet-2582	16	12	2582	2582	NUM
admet-2582	16	13	2	2	NUM
admet-2582	16	14	$	$	SYM
admet-2582	16	15	16.4	16.4	NUM
admet-2582	16	16	billion	billion	NUM
admet-2582	16	17	in	in	ADP
admet-2582	16	18	2026	2026	NUM
admet-2582	16	19	[	[	X
admet-2582	16	20	2	2	NUM
admet-2582	16	21	]	]	PUNCT
admet-2582	16	22	.	.	PUNCT
admet-2582	17	1	therefore	therefore	ADV
admet-2582	17	2	,	,	PUNCT
admet-2582	17	3	researchers	researcher	NOUN
admet-2582	17	4	have	have	AUX
admet-2582	17	5	continuously	continuously	ADV
admet-2582	17	6	increased	increase	VERB
admet-2582	17	7	their	their	PRON
admet-2582	17	8	enthusiasm	enthusiasm	NOUN
admet-2582	17	9	for	for	ADP
admet-2582	17	10	adc	adc	PROPN
admet-2582	17	11	in	in	ADP
admet-2582	17	12	recent	recent	ADJ
admet-2582	17	13	years	year	NOUN
admet-2582	17	14	.	.	PUNCT
admet-2582	18	1	as	as	ADP
admet-2582	18	2	of	of	ADP
admet-2582	18	3	february	february	PROPN
admet-2582	18	4	2024	2024	NUM
admet-2582	18	5	,	,	PUNCT
admet-2582	18	6	fifteen	fifteen	NUM
admet-2582	18	7	adcs	adc	NOUN
admet-2582	18	8	have	have	AUX
admet-2582	18	9	been	be	AUX
admet-2582	18	10	approved	approve	VERB
admet-2582	18	11	for	for	ADP
admet-2582	18	12	marketing	marketing	NOUN
admet-2582	18	13	worldwide	worldwide	ADV
admet-2582	18	14	,	,	PUNCT
admet-2582	18	15	and	and	CCONJ
admet-2582	18	16	about	about	ADV
admet-2582	18	17	260	260	NUM
admet-2582	18	18	are	be	AUX
admet-2582	18	19	in	in	ADP
admet-2582	18	20	clinical	clinical	ADJ
admet-2582	18	21	studies	study	NOUN
admet-2582	18	22	.	.	PUNCT
admet-2582	19	1	disitamab	disitamab	NOUN
admet-2582	19	2	vedotin	vedotin	ADJ
admet-2582	19	3	(	(	PUNCT
admet-2582	19	4	dv	dv	PROPN
admet-2582	19	5	)	)	PUNCT
admet-2582	19	6	,	,	PUNCT
admet-2582	19	7	developed	develop	VERB
admet-2582	19	8	by	by	ADP
admet-2582	19	9	remegen	remegen	NOUN
admet-2582	19	10	.	.	PUNCT
admet-2582	19	11	co.	co.	PROPN
admet-2582	19	12	,	,	PUNCT
admet-2582	19	13	ltd	ltd	PROPN
admet-2582	19	14	,	,	PUNCT
admet-2582	19	15	was	be	AUX
admet-2582	19	16	approved	approve	VERB
admet-2582	19	17	by	by	ADP
admet-2582	19	18	the	the	DET
admet-2582	19	19	national	national	PROPN
admet-2582	19	20	medical	medical	PROPN
admet-2582	19	21	products	product	NOUN
admet-2582	19	22	administration	administration	PROPN
admet-2582	19	23	(	(	PUNCT
admet-2582	19	24	nmpa	nmpa	PROPN
admet-2582	19	25	)	)	PUNCT
admet-2582	19	26	for	for	ADP
admet-2582	19	27	the	the	DET
admet-2582	19	28	treatment	treatment	NOUN
admet-2582	19	29	of	of	ADP
admet-2582	19	30	advanced	advanced	ADJ
admet-2582	19	31	gastric	gastric	ADJ
admet-2582	19	32	cancer	cancer	NOUN
admet-2582	19	33	in	in	ADP
admet-2582	19	34	2021	2021	NUM
admet-2582	19	35	.	.	PUNCT
admet-2582	20	1	dv	dv	PROPN
admet-2582	20	2	also	also	ADV
admet-2582	20	3	received	receive	VERB
admet-2582	20	4	food	food	NOUN
admet-2582	20	5	and	and	CCONJ
admet-2582	20	6	drug	drug	NOUN
admet-2582	20	7	administration	administration	NOUN
admet-2582	20	8	investigational	investigational	ADJ
admet-2582	20	9	new	new	ADJ
admet-2582	20	10	drug	drug	NOUN
admet-2582	20	11	(	(	PUNCT
admet-2582	20	12	fda	fda	PROPN
admet-2582	20	13	ind	ind	PROPN
admet-2582	20	14	)	)	PUNCT
admet-2582	20	15	approval	approval	NOUN
admet-2582	20	16	for	for	ADP
admet-2582	20	17	gastric	gastric	ADJ
admet-2582	20	18	cancer	cancer	NOUN
admet-2582	20	19	or	or	CCONJ
admet-2582	20	20	gastroesophageal	gastroesophageal	VERB
admet-2582	20	21	junction	junction	NOUN
admet-2582	20	22	cancer	cancer	NOUN
admet-2582	20	23	in	in	ADP
admet-2582	20	24	2020	2020	NUM
admet-2582	20	25	and	and	CCONJ
admet-2582	20	26	was	be	AUX
admet-2582	20	27	awarded	award	VERB
admet-2582	20	28	breakthrough	breakthrough	NOUN
admet-2582	20	29	therapy	therapy	NOUN
admet-2582	20	30	designation	designation	NOUN
admet-2582	20	31	for	for	ADP
admet-2582	20	32	urothelial	urothelial	ADJ
admet-2582	20	33	cancer	cancer	NOUN
admet-2582	20	34	by	by	ADP
admet-2582	20	35	the	the	DET
admet-2582	20	36	fda	fda	PROPN
admet-2582	20	37	in	in	ADP
admet-2582	20	38	the	the	DET
admet-2582	20	39	same	same	ADJ
admet-2582	20	40	year	year	NOUN
admet-2582	20	41	[	[	X
admet-2582	20	42	3	3	NUM
admet-2582	20	43	]	]	PUNCT
admet-2582	20	44	.	.	PUNCT
admet-2582	21	1	dv	dv	PROPN
admet-2582	21	2	,	,	PUNCT
admet-2582	21	3	an	an	DET
admet-2582	21	4	adc	adc	NOUN
admet-2582	21	5	composed	compose	VERB
admet-2582	21	6	of	of	ADP
admet-2582	21	7	a	a	DET
admet-2582	21	8	humanized	humanize	VERB
admet-2582	21	9	igg1	igg1	NOUN
admet-2582	21	10	mab	mab	NOUN
admet-2582	21	11	(	(	PUNCT
admet-2582	21	12	hertuzumab	hertuzumab	NOUN
admet-2582	21	13	)	)	PUNCT
admet-2582	21	14	targeting	target	VERB
admet-2582	21	15	her2	her2	NOUN
admet-2582	21	16	conjugated	conjugate	VERB
admet-2582	21	17	to	to	ADP
admet-2582	21	18	a	a	DET
admet-2582	21	19	microtubule	microtubule	NOUN
admet-2582	21	20	-	-	PUNCT
admet-2582	21	21	disrupting	disrupt	VERB
admet-2582	21	22	drug	drug	NOUN
admet-2582	21	23	mmae	mmae	NOUN
admet-2582	21	24	via	via	ADP
admet-2582	21	25	a	a	DET
admet-2582	21	26	cleavable	cleavable	ADJ
admet-2582	21	27	dipeptide	dipeptide	NOUN
admet-2582	21	28	linker	linker	NOUN
admet-2582	21	29	.	.	PUNCT
admet-2582	22	1	dv	dv	PROPN
admet-2582	22	2	showed	show	VERB
admet-2582	22	3	superior	superior	ADJ
admet-2582	22	4	antitumor	antitumor	NOUN
admet-2582	22	5	activity	activity	NOUN
admet-2582	22	6	than	than	ADP
admet-2582	22	7	t	t	NOUN
admet-2582	22	8	-	-	PUNCT
admet-2582	22	9	dm1	dm1	NOUN
admet-2582	22	10	in	in	ADP
admet-2582	22	11	trastuzumaband	trastuzumaband	NOUN
admet-2582	22	12	lapatinib	lapatinib	VERB
admet-2582	22	13	-	-	PUNCT
admet-2582	22	14	resistant	resistant	ADJ
admet-2582	22	15	xenograft	xenograft	NOUN
admet-2582	22	16	tumour	tumour	NOUN
admet-2582	22	17	models	model	NOUN
admet-2582	22	18	,	,	PUNCT
admet-2582	22	19	suggesting	suggest	VERB
admet-2582	22	20	its	its	PRON
admet-2582	22	21	potential	potential	NOUN
admet-2582	22	22	as	as	ADP
admet-2582	22	23	an	an	DET
admet-2582	22	24	improved	improved	ADJ
admet-2582	22	25	therapy	therapy	NOUN
admet-2582	22	26	for	for	ADP
admet-2582	22	27	her2	her2	PROPN
admet-2582	22	28	-	-	PUNCT
admet-2582	22	29	positive	positive	ADJ
admet-2582	22	30	breast	breast	NOUN
admet-2582	22	31	cancers	cancer	NOUN
admet-2582	22	32	[	[	X
admet-2582	22	33	7	7	NUM
admet-2582	22	34	-	-	SYM
admet-2582	22	35	8	8	NUM
admet-2582	22	36	]	]	PUNCT
admet-2582	22	37	.	.	PUNCT
admet-2582	23	1	the	the	DET
admet-2582	23	2	absorption	absorption	NOUN
admet-2582	23	3	,	,	PUNCT
admet-2582	23	4	distribution	distribution	NOUN
admet-2582	23	5	,	,	PUNCT
admet-2582	23	6	metabolism	metabolism	NOUN
admet-2582	23	7	,	,	PUNCT
admet-2582	23	8	and	and	CCONJ
admet-2582	23	9	excretion	excretion	NOUN
admet-2582	23	10	(	(	PUNCT
admet-2582	23	11	adme	adme	NOUN
admet-2582	23	12	)	)	PUNCT
admet-2582	23	13	studies	study	NOUN
admet-2582	23	14	for	for	ADP
admet-2582	23	15	therapeutic	therapeutic	ADJ
admet-2582	23	16	biologics	biologic	NOUN
admet-2582	23	17	could	could	AUX
admet-2582	23	18	be	be	AUX
admet-2582	23	19	a	a	DET
admet-2582	23	20	challenging	challenging	ADJ
admet-2582	23	21	task	task	NOUN
admet-2582	23	22	due	due	ADP
admet-2582	23	23	to	to	ADP
admet-2582	23	24	the	the	DET
admet-2582	23	25	complex	complex	ADJ
admet-2582	23	26	natures	nature	NOUN
admet-2582	23	27	(	(	PUNCT
admet-2582	23	28	e.g.	e.g.	ADV
admet-2582	23	29	adc	adc	PROPN
admet-2582	23	30	conjugate	conjugate	NOUN
admet-2582	23	31	,	,	PUNCT
admet-2582	23	32	ta	ta	ADP
admet-2582	23	33	,	,	PUNCT
admet-2582	23	34	and	and	CCONJ
admet-2582	23	35	unconjugated	unconjugate	VERB
admet-2582	23	36	cytotoxic	cytotoxic	ADJ
admet-2582	23	37	drug	drug	NOUN
admet-2582	23	38	)	)	PUNCT
admet-2582	23	39	of	of	ADP
admet-2582	23	40	these	these	DET
admet-2582	23	41	novel	novel	ADJ
admet-2582	23	42	molecules	molecule	NOUN
admet-2582	23	43	and	and	CCONJ
admet-2582	23	44	limited	limited	ADJ
admet-2582	23	45	bioanalytical	bioanalytical	ADJ
admet-2582	23	46	methods	method	NOUN
admet-2582	23	47	[	[	X
admet-2582	23	48	9	9	NUM
admet-2582	23	49	]	]	PUNCT
admet-2582	23	50	.	.	PUNCT
admet-2582	24	1	nevertheless	nevertheless	ADV
admet-2582	24	2	,	,	PUNCT
admet-2582	24	3	knowledge	knowledge	NOUN
admet-2582	24	4	gained	gain	VERB
admet-2582	24	5	from	from	ADP
admet-2582	24	6	indepth	indepth	ADJ
admet-2582	24	7	studies	study	NOUN
admet-2582	24	8	of	of	ADP
admet-2582	24	9	nonclinical	nonclinical	ADJ
admet-2582	24	10	and	and	CCONJ
admet-2582	24	11	clinical	clinical	ADJ
admet-2582	24	12	adme	adme	NOUN
admet-2582	24	13	mechanistics	mechanistic	NOUN
admet-2582	24	14	will	will	AUX
admet-2582	24	15	advance	advance	VERB
admet-2582	24	16	our	our	PRON
admet-2582	24	17	understanding	understanding	NOUN
admet-2582	24	18	of	of	ADP
admet-2582	24	19	the	the	DET
admet-2582	24	20	in	in	ADP
admet-2582	24	21	vivo	vivo	ADJ
admet-2582	24	22	disposition	disposition	NOUN
admet-2582	24	23	of	of	ADP
admet-2582	24	24	various	various	ADJ
admet-2582	24	25	therapeutic	therapeutic	ADJ
admet-2582	24	26	biologics	biologic	NOUN
admet-2582	24	27	.	.	PUNCT
admet-2582	25	1	in	in	ADP
admet-2582	25	2	addition	addition	NOUN
admet-2582	25	3	,	,	PUNCT
admet-2582	25	4	adme	adme	NOUN
admet-2582	25	5	knowledge	knowledge	NOUN
admet-2582	25	6	contributes	contribute	VERB
admet-2582	25	7	to	to	ADP
admet-2582	25	8	understanding	understand	VERB
admet-2582	25	9	clinical	clinical	ADJ
admet-2582	25	10	toxicity	toxicity	NOUN
admet-2582	25	11	,	,	PUNCT
admet-2582	25	12	optimizing	optimize	VERB
admet-2582	25	13	dispositional	dispositional	ADJ
admet-2582	25	14	properties	property	NOUN
admet-2582	25	15	,	,	PUNCT
admet-2582	25	16	improving	improve	VERB
admet-2582	25	17	human	human	ADJ
admet-2582	25	18	efficacy	efficacy	NOUN
admet-2582	25	19	,	,	PUNCT
admet-2582	25	20	and	and	CCONJ
admet-2582	25	21	the	the	DET
admet-2582	25	22	safety	safety	NOUN
admet-2582	25	23	of	of	ADP
admet-2582	25	24	new	new	ADJ
admet-2582	25	25	therapeutic	therapeutic	ADJ
admet-2582	25	26	biologics	biologic	NOUN
admet-2582	25	27	[	[	X
admet-2582	25	28	10	10	NUM
admet-2582	25	29	]	]	PUNCT
admet-2582	25	30	.	.	PUNCT
admet-2582	26	1	as	as	ADP
admet-2582	26	2	a	a	DET
admet-2582	26	3	result	result	NOUN
admet-2582	26	4	,	,	PUNCT
admet-2582	26	5	a	a	DET
admet-2582	26	6	deep	deep	ADJ
admet-2582	26	7	and	and	CCONJ
admet-2582	26	8	thorough	thorough	ADJ
admet-2582	26	9	understanding	understanding	NOUN
admet-2582	26	10	of	of	ADP
admet-2582	26	11	the	the	DET
admet-2582	26	12	preclinical	preclinical	ADJ
admet-2582	26	13	adme	adme	NOUN
admet-2582	26	14	properties	property	NOUN
admet-2582	26	15	of	of	ADP
admet-2582	26	16	adc	adc	PROPN
admet-2582	26	17	drugs	drug	NOUN
admet-2582	26	18	is	be	AUX
admet-2582	26	19	full	full	ADJ
admet-2582	26	20	of	of	ADP
admet-2582	26	21	challenges	challenge	NOUN
admet-2582	26	22	but	but	CCONJ
admet-2582	26	23	very	very	ADV
admet-2582	26	24	meaningful	meaningful	ADJ
admet-2582	26	25	.	.	PUNCT
admet-2582	27	1	preclinical	preclinical	ADJ
admet-2582	27	2	adme	adme	NOUN
admet-2582	27	3	is	be	AUX
admet-2582	27	4	usually	usually	ADV
admet-2582	27	5	performed	perform	VERB
admet-2582	27	6	in	in	ADP
admet-2582	27	7	rodents	rodent	NOUN
admet-2582	27	8	,	,	PUNCT
admet-2582	27	9	and	and	CCONJ
admet-2582	27	10	radio	radio	NOUN
admet-2582	27	11	labelling	labelling	NOUN
admet-2582	27	12	techniques	technique	NOUN
admet-2582	27	13	are	be	AUX
admet-2582	27	14	used	use	VERB
admet-2582	27	15	in	in	ADP
admet-2582	27	16	tissue	tissue	NOUN
admet-2582	27	17	distribution	distribution	NOUN
admet-2582	27	18	,	,	PUNCT
admet-2582	27	19	metabolism	metabolism	NOUN
admet-2582	27	20	and	and	CCONJ
admet-2582	27	21	excretion	excretion	NOUN
admet-2582	27	22	experiments	experiment	NOUN
admet-2582	27	23	[	[	X
admet-2582	27	24	14	14	NUM
admet-2582	27	25	]	]	PUNCT
admet-2582	27	26	.	.	PUNCT
admet-2582	28	1	in	in	ADP
admet-2582	28	2	this	this	DET
admet-2582	28	3	paper	paper	NOUN
admet-2582	28	4	,	,	PUNCT
admet-2582	28	5	we	we	PRON
admet-2582	28	6	carried	carry	VERB
admet-2582	28	7	out	out	ADP
admet-2582	28	8	the	the	DET
admet-2582	28	9	pk	pk	NOUN
admet-2582	28	10	,	,	PUNCT
admet-2582	28	11	distribution	distribution	NOUN
admet-2582	28	12	,	,	PUNCT
admet-2582	28	13	excretion	excretion	NOUN
admet-2582	28	14	(	(	PUNCT
admet-2582	28	15	125i/3h	125i/3h	NUM
admet-2582	28	16	labelled	label	VERB
admet-2582	28	17	)	)	PUNCT
admet-2582	28	18	,	,	PUNCT
admet-2582	28	19	and	and	CCONJ
admet-2582	28	20	metabolism	metabolism	NOUN
admet-2582	28	21	preclinical	preclinical	ADJ
admet-2582	28	22	study	study	NOUN
admet-2582	28	23	in	in	ADP
admet-2582	28	24	rodents	rodent	NOUN
admet-2582	28	25	to	to	PART
admet-2582	28	26	illustrate	illustrate	VERB
admet-2582	28	27	the	the	DET
admet-2582	28	28	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	28	29	,	,	PUNCT
admet-2582	28	30	metabolite	metabolite	NOUN
admet-2582	28	31	,	,	PUNCT
admet-2582	28	32	and	and	CCONJ
admet-2582	28	33	disposition	disposition	NOUN
admet-2582	28	34	characteristic	characteristic	NOUN
admet-2582	28	35	of	of	ADP
admet-2582	28	36	dv	dv	PROPN
admet-2582	28	37	.	.	PUNCT
admet-2582	28	38	to	to	PART
admet-2582	28	39	provide	provide	VERB
admet-2582	28	40	more	more	ADJ
admet-2582	28	41	theoretical	theoretical	ADJ
admet-2582	28	42	basis	basis	NOUN
admet-2582	28	43	and	and	CCONJ
admet-2582	28	44	data	datum	NOUN
admet-2582	28	45	support	support	NOUN
admet-2582	28	46	for	for	ADP
admet-2582	28	47	clinical	clinical	NOUN
admet-2582	28	48	.	.	PUNCT
admet-2582	29	1	the	the	DET
admet-2582	29	2	adme	adme	NOUN
admet-2582	29	3	studies	study	NOUN
admet-2582	29	4	have	have	AUX
admet-2582	29	5	provided	provide	VERB
admet-2582	29	6	more	more	ADJ
admet-2582	29	7	theoretical	theoretical	ADJ
admet-2582	29	8	basis	basis	NOUN
admet-2582	29	9	and	and	CCONJ
admet-2582	29	10	data	datum	NOUN
admet-2582	29	11	support	support	NOUN
admet-2582	29	12	for	for	ADP
admet-2582	29	13	clinical	clinical	ADJ
admet-2582	29	14	and	and	CCONJ
admet-2582	29	15	will	will	AUX
admet-2582	29	16	provide	provide	VERB
admet-2582	29	17	references	reference	NOUN
admet-2582	29	18	for	for	ADP
admet-2582	29	19	future	future	ADJ
admet-2582	29	20	adc	adc	PROPN
admet-2582	29	21	development	development	NOUN
admet-2582	29	22	.	.	PUNCT
admet-2582	30	1	materials	material	NOUN
admet-2582	30	2	and	and	CCONJ
admet-2582	30	3	methods	method	NOUN
admet-2582	30	4	antibodies	antibodie	VERB
admet-2582	30	5	and	and	CCONJ
admet-2582	30	6	antibody	antibody	NOUN
admet-2582	30	7	-	-	PUNCT
admet-2582	30	8	conjugated	conjugate	VERB
admet-2582	30	9	drugs	drug	NOUN
admet-2582	30	10	disitamab	disitamab	VERB
admet-2582	30	11	vedotin	vedotin	ADJ
admet-2582	30	12	(	(	PUNCT
admet-2582	30	13	dv	dv	PROPN
admet-2582	30	14	)	)	PUNCT
admet-2582	30	15	was	be	AUX
admet-2582	30	16	generated	generate	VERB
admet-2582	30	17	by	by	ADP
admet-2582	30	18	remegen	remegen	PROPN
admet-2582	30	19	co.	co.	PROPN
admet-2582	30	20	,	,	PUNCT
admet-2582	30	21	ltd	ltd	PROPN
admet-2582	30	22	.	.	PROPN
admet-2582	30	23	,	,	PUNCT
admet-2582	30	24	as	as	SCONJ
admet-2582	30	25	described	describe	VERB
admet-2582	30	26	previously	previously	ADV
admet-2582	30	27	[	[	X
admet-2582	30	28	3	3	NUM
admet-2582	30	29	]	]	PUNCT
admet-2582	30	30	.	.	PUNCT
admet-2582	31	1	the	the	DET
admet-2582	31	2	average	average	ADJ
admet-2582	31	3	drug	drug	NOUN
admet-2582	31	4	-	-	PUNCT
admet-2582	31	5	antibody	antibody	NOUN
admet-2582	31	6	ratio	ratio	NOUN
admet-2582	31	7	(	(	PUNCT
admet-2582	31	8	dar	dar	NOUN
admet-2582	31	9	)	)	PUNCT
admet-2582	31	10	was	be	AUX
admet-2582	31	11	3.5	3.5	NUM
admet-2582	31	12	-	-	SYM
admet-2582	31	13	4.5	4.5	NUM
admet-2582	31	14	mmae	mmae	NOUN
admet-2582	31	15	per	per	ADP
admet-2582	31	16	mab	mab	NOUN
admet-2582	31	17	.	.	PUNCT
admet-2582	32	1	radiochemistry	radiochemistry	NOUN
admet-2582	32	2	for	for	ADP
admet-2582	32	3	[	[	X
admet-2582	32	4	125i	125i	NOUN
admet-2582	32	5	]	]	X
admet-2582	32	6	radiolabeling	radiolabeling	NOUN
admet-2582	32	7	,	,	PUNCT
admet-2582	32	8	iodogen	iodogen	PROPN
admet-2582	32	9	(	(	PUNCT
admet-2582	32	10	sigma	sigma	PROPN
admet-2582	32	11	-	-	PUNCT
admet-2582	32	12	aldrich	aldrich	PROPN
admet-2582	32	13	,	,	PUNCT
admet-2582	32	14	st	st	PROPN
admet-2582	32	15	.	.	PROPN
admet-2582	32	16	louis	louis	PROPN
admet-2582	32	17	,	,	PUNCT
admet-2582	32	18	mo	mo	PROPN
admet-2582	32	19	,	,	PUNCT
admet-2582	32	20	usa	usa	PROPN
admet-2582	32	21	)	)	PUNCT
admet-2582	32	22	was	be	AUX
admet-2582	32	23	added	add	VERB
admet-2582	32	24	to	to	ADP
admet-2582	32	25	the	the	DET
admet-2582	32	26	test	test	NOUN
admet-2582	32	27	tube	tube	NOUN
admet-2582	32	28	and	and	CCONJ
admet-2582	32	29	,	,	PUNCT
admet-2582	32	30	subsequently	subsequently	ADV
admet-2582	32	31	,	,	PUNCT
admet-2582	32	32	conjugated	conjugate	VERB
admet-2582	32	33	to	to	ADP
admet-2582	32	34	the	the	DET
admet-2582	32	35	dv	dv	PROPN
admet-2582	32	36	(	(	PUNCT
admet-2582	32	37	remegen	remegen	PROPN
admet-2582	32	38	,	,	PUNCT
admet-2582	32	39	yantai	yantai	PROPN
admet-2582	32	40	,	,	PUNCT
admet-2582	32	41	cn	cn	PROPN
admet-2582	32	42	)	)	PUNCT
admet-2582	32	43	.	.	PUNCT
admet-2582	33	1	then	then	ADV
admet-2582	33	2	,	,	PUNCT
admet-2582	33	3	to	to	PART
admet-2582	33	4	remove	remove	VERB
admet-2582	33	5	the	the	DET
admet-2582	33	6	excess	excess	ADJ
admet-2582	33	7	unconjugated	unconjugated	ADJ
admet-2582	33	8	[	[	X
admet-2582	33	9	125i	125i	NOUN
admet-2582	33	10	]	]	PUNCT
admet-2582	33	11	,	,	PUNCT
admet-2582	33	12	the	the	DET
admet-2582	33	13	solution	solution	NOUN
admet-2582	33	14	was	be	AUX
admet-2582	33	15	passed	pass	VERB
admet-2582	33	16	through	through	ADP
admet-2582	33	17	a	a	DET
admet-2582	33	18	150	150	PROPN
admet-2582	33	19	cm	cm	PROPN
admet-2582	33	20	sephadex	sephadex	PROPN
admet-2582	33	21	g10	g10	PROPN
admet-2582	33	22	column	column	PROPN
admet-2582	33	23	(	(	PUNCT
admet-2582	33	24	pharmacia	pharmacia	PROPN
admet-2582	33	25	,	,	PUNCT
admet-2582	33	26	new	new	PROPN
admet-2582	33	27	york	york	PROPN
admet-2582	33	28	,	,	PUNCT
admet-2582	33	29	usa	usa	PROPN
admet-2582	33	30	)	)	PUNCT
admet-2582	33	31	.	.	PUNCT
admet-2582	34	1	the	the	DET
admet-2582	34	2	radiolabeling	radiolabele	VERB
admet-2582	34	3	dv	dv	PROPN
admet-2582	34	4	was	be	AUX
admet-2582	34	5	characterized	characterize	VERB
admet-2582	34	6	by	by	ADP
admet-2582	34	7	radiochemical	radiochemical	ADJ
admet-2582	34	8	purity	purity	NOUN
admet-2582	34	9	,	,	PUNCT
admet-2582	34	10	protein	protein	NOUN
admet-2582	34	11	content	content	NOUN
admet-2582	34	12	,	,	PUNCT
admet-2582	34	13	and	and	CCONJ
admet-2582	34	14	bioactivity	bioactivity	NOUN
admet-2582	34	15	.	.	PUNCT
admet-2582	35	1	the	the	DET
admet-2582	35	2	[	[	X
admet-2582	35	3	3h	3h	NUM
admet-2582	35	4	]	]	PUNCT
admet-2582	35	5	mmae	mmae	NOUN
admet-2582	35	6	(	(	PUNCT
admet-2582	35	7	lot	lot	NOUN
admet-2582	35	8	:	:	PUNCT
admet-2582	35	9	k0903	k0903	PROPN
admet-2582	35	10	)	)	PUNCT
admet-2582	35	11	and	and	CCONJ
admet-2582	35	12	mc	mc	PROPN
admet-2582	35	13	-	-	PUNCT
admet-2582	35	14	val	val	PROPN
admet-2582	35	15	-	-	PUNCT
admet-2582	35	16	cit	cit	ADJ
admet-2582	35	17	-	-	PUNCT
admet-2582	35	18	pab	pab	NOUN
admet-2582	35	19	-	-	PUNCT
admet-2582	35	20	c-[3h	c-[3h	NOUN
admet-2582	35	21	]	]	PUNCT
admet-2582	35	22	mmae	mmae	NOUN
admet-2582	35	23	(	(	PUNCT
admet-2582	35	24	lot	lot	NOUN
admet-2582	35	25	:	:	PUNCT
admet-2582	35	26	k0904	k0904	NOUN
admet-2582	35	27	)	)	PUNCT
admet-2582	35	28	were	be	AUX
admet-2582	35	29	obtained	obtain	VERB
admet-2582	35	30	from	from	ADP
admet-2582	35	31	curachem	curachem	PROPN
admet-2582	35	32	inc	inc	PROPN
admet-2582	35	33	.	.	PROPN
admet-2582	35	34	(	(	PUNCT
admet-2582	35	35	chungcheongbuk	chungcheongbuk	NOUN
admet-2582	35	36	-	-	PUNCT
admet-2582	35	37	do	do	PROPN
admet-2582	35	38	,	,	PUNCT
admet-2582	35	39	south	south	PROPN
admet-2582	35	40	korea	korea	PROPN
admet-2582	35	41	)	)	PUNCT
admet-2582	35	42	,	,	PUNCT
admet-2582	35	43	with	with	ADP
admet-2582	35	44	a	a	DET
admet-2582	35	45	specific	specific	ADJ
admet-2582	35	46	activity	activity	NOUN
admet-2582	35	47	of	of	ADP
admet-2582	35	48	17.57	17.57	NUM
admet-2582	35	49	ci	ci	NOUN
admet-2582	35	50	/	/	SYM
admet-2582	35	51	mmol	mmol	NOUN
admet-2582	35	52	.	.	PUNCT
admet-2582	36	1	mc	mc	PROPN
admet-2582	36	2	-	-	PUNCT
admet-2582	36	3	val	val	PROPN
admet-2582	36	4	-	-	PUNCT
admet-2582	36	5	cit	cit	ADJ
admet-2582	36	6	-	-	PUNCT
admet-2582	36	7	pab	pab	NOUN
admet-2582	36	8	-	-	PUNCT
admet-2582	36	9	c-[3h	c-[3h	NOUN
admet-2582	36	10	]	]	PUNCT
admet-2582	36	11	mmae	mmae	NOUN
admet-2582	36	12	with	with	ADP
admet-2582	36	13	the	the	DET
admet-2582	36	14	specific	specific	ADJ
admet-2582	36	15	activity	activity	NOUN
admet-2582	36	16	of	of	ADP
admet-2582	36	17	17.57	17.57	NUM
admet-2582	36	18	ci	ci	NOUN
admet-2582	36	19	/	/	SYM
admet-2582	36	20	mmol	mmol	PROPN
admet-2582	36	21	(	(	PUNCT
admet-2582	36	22	curachem	curachem	PROPN
admet-2582	36	23	inc	inc	PROPN
admet-2582	36	24	.	.	PROPN
admet-2582	36	25	,	,	PUNCT
admet-2582	36	26	chungcheongbuk	chungcheongbuk	NOUN
admet-2582	36	27	-	-	PUNCT
admet-2582	36	28	do	do	VERB
admet-2582	36	29	,	,	PUNCT
admet-2582	36	30	south	south	PROPN
admet-2582	36	31	korea	korea	PROPN
admet-2582	36	32	)	)	PUNCT
admet-2582	36	33	was	be	AUX
admet-2582	36	34	conjugating	conjugate	VERB
admet-2582	36	35	to	to	ADP
admet-2582	36	36	rc48	rc48	PROPN
admet-2582	36	37	-	-	PUNCT
admet-2582	36	38	adc	adc	PROPN
admet-2582	36	39	mab	mab	NOUN
admet-2582	36	40	,	,	PUNCT
admet-2582	36	41	as	as	SCONJ
admet-2582	36	42	described	describe	VERB
admet-2582	36	43	in	in	ADP
admet-2582	36	44	the	the	DET
admet-2582	36	45	above	above	ADJ
admet-2582	36	46	previously	previously	ADV
admet-2582	36	47	error	error	NOUN
admet-2582	36	48	!	!	PUNCT
admet-2582	37	1	reference	reference	NOUN
admet-2582	37	2	source	source	NOUN
admet-2582	37	3	not	not	PART
admet-2582	37	4	found	find	VERB
admet-2582	37	5	..	..	PUNCT
admet-2582	38	1	the	the	DET
admet-2582	38	2	r	r	NOUN
admet-2582	38	3	esulting	esulte	VERB
admet-2582	38	4	[	[	PUNCT
admet-2582	38	5	3h	3h	NUM
admet-2582	38	6	-	-	PUNCT
admet-2582	38	7	mmae]-rc48	mmae]-rc48	NOUN
admet-2582	38	8	-	-	PUNCT
admet-2582	38	9	adc	adc	NOUN
admet-2582	38	10	had	have	VERB
admet-2582	38	11	a	a	DET
admet-2582	38	12	specific	specific	ADJ
admet-2582	38	13	activity	activity	NOUN
admet-2582	38	14	of	of	ADP
admet-2582	38	15	254	254	NUM
admet-2582	38	16	µci	µci	ADJ
admet-2582	38	17	/	/	SYM
admet-2582	38	18	ml	ml	PROPN
admet-2582	38	19	and	and	CCONJ
admet-2582	38	20	a	a	DET
admet-2582	38	21	dar	dar	NOUN
admet-2582	38	22	of	of	ADP
admet-2582	38	23	3.96	3.96	NUM
admet-2582	38	24	.	.	PUNCT
admet-2582	39	1	the	the	DET
admet-2582	39	2	structure	structure	NOUN
admet-2582	39	3	of	of	ADP
admet-2582	39	4	[	[	X
admet-2582	39	5	3h	3h	NUM
admet-2582	39	6	]	]	PUNCT
admet-2582	39	7	mmae	mmae	NOUN
admet-2582	39	8	and	and	CCONJ
admet-2582	39	9	mc	mc	PROPN
admet-2582	39	10	-	-	PUNCT
admet-2582	39	11	val	val	PROPN
admet-2582	39	12	-	-	PUNCT
admet-2582	39	13	cit	cit	ADJ
admet-2582	39	14	-	-	PUNCT
admet-2582	39	15	pab	pab	NOUN
admet-2582	39	16	-	-	PUNCT
admet-2582	39	17	c-[3h	c-[3h	NOUN
admet-2582	39	18	]	]	PUNCT
admet-2582	39	19	mmae	mmae	NOUN
admet-2582	39	20	are	be	AUX
admet-2582	39	21	shown	show	VERB
admet-2582	39	22	in	in	ADP
admet-2582	39	23	figure	figure	NOUN
admet-2582	39	24	1a	1a	NOUN
admet-2582	39	25	and	and	CCONJ
admet-2582	39	26	figure	figure	VERB
admet-2582	39	27	1b	1b	NUM
admet-2582	39	28	,	,	PUNCT
admet-2582	39	29	respectively	respectively	ADV
admet-2582	39	30	.	.	PUNCT
admet-2582	40	1	admet	admet	PROPN
admet-2582	40	2	&	&	CCONJ
admet-2582	40	3	dmpk	dmpk	PROPN
admet-2582	40	4	13(2	13(2	PROPN
admet-2582	40	5	)	)	PUNCT
admet-2582	40	6	(	(	PUNCT
admet-2582	40	7	2025	2025	NUM
admet-2582	40	8	)	)	PUNCT
admet-2582	40	9	2582	2582	NUM
admet-2582	40	10	disitamab	disitamab	VERB
admet-2582	40	11	vedotin	vedotin	ADJ
admet-2582	40	12	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	40	13	,	,	PUNCT
admet-2582	40	14	distribution	distribution	NOUN
admet-2582	40	15	and	and	CCONJ
admet-2582	40	16	metabolism	metabolism	NOUN
admet-2582	40	17	doi	doi	NOUN
admet-2582	40	18	:	:	PUNCT
admet-2582	40	19	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	40	20	3	3	NUM
admet-2582	40	21	a	a	PRON
admet-2582	40	22	b	b	NUM
admet-2582	40	23	figure	figure	NOUN
admet-2582	40	24	1	1	NUM
admet-2582	40	25	.	.	PUNCT
admet-2582	40	26	structure	structure	NOUN
admet-2582	40	27	of	of	ADP
admet-2582	40	28	[	[	X
admet-2582	40	29	3h	3h	NUM
admet-2582	40	30	]	]	PUNCT
admet-2582	40	31	mmae	mmae	NOUN
admet-2582	40	32	(	(	PUNCT
admet-2582	40	33	a	a	NOUN
admet-2582	40	34	)	)	PUNCT
admet-2582	40	35	and	and	CCONJ
admet-2582	40	36	mc	mc	PROPN
admet-2582	40	37	-	-	PUNCT
admet-2582	40	38	val	val	PROPN
admet-2582	40	39	-	-	PUNCT
admet-2582	40	40	cit	cit	ADJ
admet-2582	40	41	-	-	PUNCT
admet-2582	40	42	pab	pab	NOUN
admet-2582	40	43	-	-	PUNCT
admet-2582	40	44	c-[3h	c-[3h	NOUN
admet-2582	40	45	]	]	SYM
admet-2582	40	46	mmae(b	mmae(b	ADJ
admet-2582	40	47	)	)	PUNCT
admet-2582	40	48	animal	animal	NOUN
admet-2582	40	49	housing	housing	NOUN
admet-2582	40	50	and	and	CCONJ
admet-2582	40	51	procedure	procedure	NOUN
admet-2582	40	52	all	all	DET
admet-2582	40	53	animals	animal	NOUN
admet-2582	40	54	in	in	ADP
admet-2582	40	55	the	the	DET
admet-2582	40	56	study	study	NOUN
admet-2582	40	57	were	be	AUX
admet-2582	40	58	purchased	purchase	VERB
admet-2582	40	59	from	from	ADP
admet-2582	40	60	qualified	qualified	ADJ
admet-2582	40	61	laboratory	laboratory	NOUN
admet-2582	40	62	animal	animal	NOUN
admet-2582	40	63	technology	technology	PROPN
admet-2582	40	64	co.	co.	PROPN
admet-2582	40	65	,	,	PUNCT
admet-2582	40	66	ltd	ltd	PROPN
admet-2582	40	67	(	(	PUNCT
admet-2582	40	68	production	production	NOUN
admet-2582	40	69	license	license	NOUN
admet-2582	40	70	number	number	NOUN
admet-2582	40	71	:	:	PUNCT
admet-2582	40	72	2018	2018	NUM
admet-2582	40	73	-	-	SYM
admet-2582	40	74	0001	0001	NUM
admet-2582	40	75	,	,	PUNCT
admet-2582	40	76	2016	2016	NUM
admet-2582	40	77	-	-	SYM
admet-2582	40	78	0011	0011	NUM
admet-2582	40	79	,	,	PUNCT
admet-2582	40	80	2012	2012	NUM
admet-2582	40	81	-	-	SYM
admet-2582	40	82	002	002	NUM
admet-2582	40	83	,	,	PUNCT
admet-2582	40	84	2012	2012	NUM
admet-2582	40	85	-	-	SYM
admet-2582	40	86	0004	0004	NUM
admet-2582	40	87	)	)	PUNCT
admet-2582	40	88	and	and	CCONJ
admet-2582	40	89	housed	house	VERB
admet-2582	40	90	in	in	ADP
admet-2582	40	91	an	an	DET
admet-2582	40	92	spf	spf	ADJ
admet-2582	40	93	environment	environment	NOUN
admet-2582	40	94	.	.	PUNCT
admet-2582	41	1	bile	bile	NOUN
admet-2582	41	2	-	-	PUNCT
admet-2582	41	3	ductcannulated	ductcannulate	VERB
admet-2582	41	4	(	(	PUNCT
admet-2582	41	5	bdc	bdc	NOUN
admet-2582	41	6	)	)	PUNCT
admet-2582	41	7	rats	rat	NOUN
admet-2582	41	8	were	be	AUX
admet-2582	41	9	obtained	obtain	VERB
admet-2582	41	10	from	from	ADP
admet-2582	41	11	charles	charles	PROPN
admet-2582	41	12	river	river	PROPN
admet-2582	41	13	laboratories	laboratory	NOUN
admet-2582	41	14	(	(	PUNCT
admet-2582	41	15	beijing	beijing	PROPN
admet-2582	41	16	,	,	PUNCT
admet-2582	41	17	cn	cn	PROPN
admet-2582	41	18	)	)	PUNCT
admet-2582	41	19	after	after	ADP
admet-2582	41	20	surgery	surgery	NOUN
admet-2582	41	21	and	and	CCONJ
admet-2582	41	22	recovery	recovery	NOUN
admet-2582	41	23	.	.	PUNCT
admet-2582	42	1	the	the	DET
admet-2582	42	2	mice	mouse	NOUN
admet-2582	42	3	were	be	AUX
admet-2582	42	4	subcutaneously	subcutaneously	ADV
admet-2582	42	5	inoculated	inoculate	VERB
admet-2582	42	6	with	with	ADP
admet-2582	42	7	human	human	ADJ
admet-2582	42	8	gastric	gastric	PROPN
admet-2582	42	9	cancer	cancer	NOUN
admet-2582	42	10	nci	nci	PROPN
admet-2582	42	11	-	-	PUNCT
admet-2582	42	12	n87	n87	NOUN
admet-2582	42	13	cells	cell	NOUN
admet-2582	42	14	.	.	PUNCT
admet-2582	43	1	follow	follow	VERB
admet-2582	43	2	-	-	PUNCT
admet-2582	43	3	up	up	ADP
admet-2582	43	4	experiments	experiment	NOUN
admet-2582	43	5	were	be	AUX
admet-2582	43	6	carried	carry	VERB
admet-2582	43	7	out	out	ADP
admet-2582	43	8	after	after	SCONJ
admet-2582	43	9	the	the	DET
admet-2582	43	10	tumours	tumour	NOUN
admet-2582	43	11	had	have	AUX
admet-2582	43	12	grown	grow	VERB
admet-2582	43	13	to	to	ADP
admet-2582	43	14	300	300	NUM
admet-2582	43	15	to	to	PART
admet-2582	43	16	400	400	NUM
admet-2582	43	17	mm3	mm3	NOUN
admet-2582	43	18	.	.	PUNCT
admet-2582	44	1	all	all	DET
admet-2582	44	2	animal	animal	NOUN
admet-2582	44	3	studies	study	NOUN
admet-2582	44	4	were	be	AUX
admet-2582	44	5	carried	carry	VERB
admet-2582	44	6	out	out	ADP
admet-2582	44	7	in	in	ADP
admet-2582	44	8	accordance	accordance	NOUN
admet-2582	44	9	with	with	ADP
admet-2582	44	10	the	the	DET
admet-2582	44	11	requirements	requirement	NOUN
admet-2582	44	12	of	of	ADP
admet-2582	44	13	the	the	DET
admet-2582	44	14	association	association	NOUN
admet-2582	44	15	for	for	ADP
admet-2582	44	16	assessment	assessment	NOUN
admet-2582	44	17	and	and	CCONJ
admet-2582	44	18	accreditation	accreditation	NOUN
admet-2582	44	19	of	of	ADP
admet-2582	44	20	laboratory	laboratory	NOUN
admet-2582	44	21	animal	animal	NOUN
admet-2582	44	22	care	care	NOUN
admet-2582	44	23	international	international	ADJ
admet-2582	44	24	.	.	PUNCT
admet-2582	45	1	all	all	DET
admet-2582	45	2	the	the	DET
admet-2582	45	3	experimental	experimental	ADJ
admet-2582	45	4	protocols	protocol	NOUN
admet-2582	45	5	have	have	AUX
admet-2582	45	6	been	be	AUX
admet-2582	45	7	reviewed	review	VERB
admet-2582	45	8	and	and	CCONJ
admet-2582	45	9	approved	approve	VERB
admet-2582	45	10	by	by	ADP
admet-2582	45	11	the	the	DET
admet-2582	45	12	institutional	institutional	ADJ
admet-2582	45	13	animal	animal	NOUN
admet-2582	45	14	care	care	NOUN
admet-2582	45	15	and	and	CCONJ
admet-2582	45	16	use	use	VERB
admet-2582	45	17	committee	committee	NOUN
admet-2582	45	18	(	(	PUNCT
admet-2582	45	19	iacuc	iacuc	NOUN
admet-2582	45	20	)	)	PUNCT
admet-2582	45	21	before	before	ADP
admet-2582	45	22	implementation	implementation	NOUN
admet-2582	45	23	.	.	PUNCT
admet-2582	46	1	pk	pk	NOUN
admet-2582	46	2	profile	profile	NOUN
admet-2582	46	3	of	of	ADP
admet-2582	46	4	rc48	rc48	PROPN
admet-2582	46	5	-	-	PUNCT
admet-2582	46	6	adc	adc	PROPN
admet-2582	46	7	and	and	CCONJ
admet-2582	46	8	mmae	mmae	NOUN
admet-2582	46	9	in	in	ADP
admet-2582	46	10	rats	rat	NOUN
admet-2582	46	11	twenty	twenty	NUM
admet-2582	46	12	-	-	PUNCT
admet-2582	46	13	four	four	NUM
admet-2582	46	14	50/50	50/50	NUM
admet-2582	46	15	male	male	ADJ
admet-2582	46	16	and	and	CCONJ
admet-2582	46	17	female	female	ADJ
admet-2582	46	18	rats	rat	NOUN
admet-2582	46	19	,	,	PUNCT
admet-2582	46	20	8	8	NUM
admet-2582	46	21	to	to	PART
admet-2582	46	22	12	12	NUM
admet-2582	46	23	weeks	week	NOUN
admet-2582	46	24	old	old	ADJ
admet-2582	46	25	,	,	PUNCT
admet-2582	46	26	weighing	weigh	VERB
admet-2582	46	27	approximately	approximately	ADV
admet-2582	46	28	200	200	NUM
admet-2582	46	29	g	g	NOUN
admet-2582	46	30	,	,	PUNCT
admet-2582	46	31	were	be	AUX
admet-2582	46	32	administered	administer	VERB
admet-2582	46	33	rc48	rc48	PROPN
admet-2582	46	34	(	(	PUNCT
admet-2582	46	35	4	4	NUM
admet-2582	46	36	,	,	PUNCT
admet-2582	46	37	8	8	NUM
admet-2582	46	38	,	,	PUNCT
admet-2582	46	39	16	16	NUM
admet-2582	46	40	mg	mg	PROPN
admet-2582	46	41	/	/	SYM
admet-2582	46	42	kg	kg	NOUN
admet-2582	46	43	)	)	PUNCT
admet-2582	46	44	or	or	CCONJ
admet-2582	46	45	rc48	rc48	PROPN
admet-2582	46	46	bare	bare	PROPN
admet-2582	46	47	ab	ab	PROPN
admet-2582	46	48	in	in	ADP
admet-2582	46	49	combination	combination	NOUN
admet-2582	46	50	with	with	ADP
admet-2582	46	51	mmae	mmae	NOUN
admet-2582	46	52	(	(	PUNCT
admet-2582	46	53	8	8	NUM
admet-2582	46	54	mg	mg	NUM
admet-2582	46	55	/	/	SYM
admet-2582	46	56	kg	kg	NOUN
admet-2582	46	57	rc48	rc48	PROPN
admet-2582	46	58	ab	ab	PROPN
admet-2582	46	59	and	and	CCONJ
admet-2582	46	60	0.16	0.16	NUM
admet-2582	46	61	mg	mg	PROPN
admet-2582	46	62	/	/	SYM
admet-2582	46	63	kg	kg	PROPN
admet-2582	46	64	mmae	mmae	NOUN
admet-2582	46	65	)	)	PUNCT
admet-2582	46	66	in	in	ADP
admet-2582	46	67	a	a	DET
admet-2582	46	68	single	single	ADJ
admet-2582	46	69	i.v	i.v	PROPN
admet-2582	46	70	.	.	PUNCT
admet-2582	46	71	dose	dose	PROPN
admet-2582	46	72	.	.	PUNCT
admet-2582	47	1	blood	blood	NOUN
admet-2582	47	2	samples	sample	NOUN
admet-2582	47	3	were	be	AUX
admet-2582	47	4	collected	collect	VERB
admet-2582	47	5	at	at	ADP
admet-2582	47	6	0min	0min	PROPN
admet-2582	47	7	(	(	PUNCT
admet-2582	47	8	predose	predose	NOUN
admet-2582	47	9	)	)	PUNCT
admet-2582	47	10	,	,	PUNCT
admet-2582	47	11	1	1	NUM
admet-2582	47	12	,	,	PUNCT
admet-2582	47	13	10	10	NUM
admet-2582	47	14	and	and	CCONJ
admet-2582	47	15	30	30	NUM
admet-2582	47	16	min	min	NOUN
admet-2582	47	17	,	,	PUNCT
admet-2582	47	18	2	2	NUM
admet-2582	47	19	and	and	CCONJ
admet-2582	47	20	8	8	NUM
admet-2582	47	21	h	h	NOUN
admet-2582	47	22	,	,	PUNCT
admet-2582	47	23	then	then	ADV
admet-2582	47	24	1	1	NUM
admet-2582	47	25	,	,	PUNCT
admet-2582	47	26	2	2	NUM
admet-2582	47	27	,	,	PUNCT
admet-2582	47	28	3	3	NUM
admet-2582	47	29	,	,	PUNCT
admet-2582	47	30	6	6	NUM
admet-2582	47	31	,	,	PUNCT
admet-2582	47	32	8	8	NUM
admet-2582	47	33	,	,	PUNCT
admet-2582	47	34	10	10	NUM
admet-2582	47	35	,	,	PUNCT
admet-2582	47	36	12	12	NUM
admet-2582	47	37	,	,	PUNCT
admet-2582	47	38	14	14	NUM
admet-2582	47	39	,	,	PUNCT
admet-2582	47	40	17	17	NUM
admet-2582	47	41	,	,	PUNCT
admet-2582	47	42	21	21	NUM
admet-2582	47	43	,	,	PUNCT
admet-2582	47	44	24	24	NUM
admet-2582	47	45	and	and	CCONJ
admet-2582	47	46	28	28	NUM
admet-2582	47	47	days	day	NOUN
admet-2582	47	48	after	after	ADP
admet-2582	47	49	administration	administration	NOUN
admet-2582	47	50	,	,	PUNCT
admet-2582	47	51	followed	follow	VERB
admet-2582	47	52	by	by	ADP
admet-2582	47	53	centrifugation	centrifugation	NOUN
admet-2582	47	54	(	(	PUNCT
admet-2582	47	55	4	4	NUM
admet-2582	47	56	°	°	NOUN
admet-2582	47	57	c	c	NOUN
admet-2582	47	58	,	,	PUNCT
admet-2582	47	59	1000	1000	NUM
admet-2582	47	60	to	to	ADP
admet-2582	47	61	2000	2000	NUM
admet-2582	47	62	g	g	NOUN
admet-2582	47	63	,	,	PUNCT
admet-2582	47	64	10	10	NUM
admet-2582	47	65	min	min	NOUN
admet-2582	47	66	)	)	PUNCT
admet-2582	47	67	to	to	PART
admet-2582	47	68	separate	separate	VERB
admet-2582	47	69	plasma	plasma	NOUN
admet-2582	47	70	.	.	PUNCT
admet-2582	48	1	the	the	DET
admet-2582	48	2	upper	upper	ADJ
admet-2582	48	3	serum	serum	NOUN
admet-2582	48	4	was	be	AUX
admet-2582	48	5	divided	divide	VERB
admet-2582	48	6	into	into	ADP
admet-2582	48	7	three	three	NUM
admet-2582	48	8	fractions	fraction	NOUN
admet-2582	48	9	and	and	CCONJ
admet-2582	48	10	analysed	analyse	VERB
admet-2582	48	11	after	after	ADP
admet-2582	48	12	freezing	freeze	VERB
admet-2582	48	13	at	at	ADP
admet-2582	48	14	-80	-80	NOUN
admet-2582	48	15	°	°	NOUN
admet-2582	48	16	c	c	NOUN
admet-2582	48	17	.	.	PUNCT
admet-2582	49	1	concentrations	concentration	NOUN
admet-2582	49	2	of	of	ADP
admet-2582	49	3	coupled	couple	VERB
admet-2582	49	4	antibodies	antibody	NOUN
admet-2582	49	5	(	(	PUNCT
admet-2582	49	6	adc	adc	PROPN
admet-2582	49	7	)	)	PUNCT
admet-2582	49	8	,	,	PUNCT
admet-2582	49	9	total	total	ADJ
admet-2582	49	10	or	or	CCONJ
admet-2582	49	11	naked	naked	ADJ
admet-2582	49	12	antibodies	antibody	NOUN
admet-2582	49	13	,	,	PUNCT
admet-2582	49	14	and	and	CCONJ
admet-2582	49	15	free	free	ADJ
admet-2582	49	16	mmae	mmae	NOUN
admet-2582	49	17	were	be	AUX
admet-2582	49	18	determined	determine	VERB
admet-2582	49	19	for	for	ADP
admet-2582	49	20	each	each	PRON
admet-2582	49	21	of	of	ADP
admet-2582	49	22	the	the	DET
admet-2582	49	23	three	three	NUM
admet-2582	49	24	fractions	fraction	NOUN
admet-2582	49	25	of	of	ADP
admet-2582	49	26	serum	serum	NOUN
admet-2582	49	27	samples	sample	NOUN
admet-2582	49	28	.	.	PUNCT
admet-2582	50	1	tissue	tissue	NOUN
admet-2582	50	2	distribution	distribution	NOUN
admet-2582	50	3	study	study	NOUN
admet-2582	50	4	with	with	ADP
admet-2582	50	5	125i	125i	PROPN
admet-2582	50	6	-	-	PUNCT
admet-2582	50	7	rc48	rc48	PROPN
admet-2582	50	8	-	-	PUNCT
admet-2582	50	9	adc	adc	NOUN
admet-2582	50	10	the	the	DET
admet-2582	50	11	tumour	tumour	NOUN
admet-2582	50	12	-	-	PUNCT
admet-2582	50	13	bearing	bear	VERB
admet-2582	50	14	nude	nude	ADJ
admet-2582	50	15	mice	mouse	NOUN
admet-2582	50	16	were	be	AUX
admet-2582	50	17	killed	kill	VERB
admet-2582	50	18	by	by	ADP
admet-2582	50	19	femoral	femoral	ADJ
admet-2582	50	20	artery	artery	NOUN
admet-2582	50	21	bleeding	bleed	VERB
admet-2582	50	22	at	at	ADP
admet-2582	50	23	4	4	NUM
admet-2582	50	24	,	,	PUNCT
admet-2582	50	25	24	24	NUM
admet-2582	50	26	,	,	PUNCT
admet-2582	50	27	72	72	NUM
admet-2582	50	28	and	and	CCONJ
admet-2582	50	29	168	168	NUM
admet-2582	50	30	h	h	NOUN
admet-2582	50	31	after	after	ADP
admet-2582	50	32	i.v	i.v	PROPN
admet-2582	50	33	.	.	PUNCT
admet-2582	51	1	injection	injection	NOUN
admet-2582	51	2	of	of	ADP
admet-2582	51	3	12	12	NUM
admet-2582	51	4	mg	mg	NUM
admet-2582	51	5	/	/	SYM
admet-2582	51	6	kg	kg	NOUN
admet-2582	51	7	125i	125i	PROPN
admet-2582	51	8	-	-	PUNCT
admet-2582	51	9	rc48	rc48	PROPN
admet-2582	51	10	-	-	PUNCT
admet-2582	51	11	adc	adc	PROPN
admet-2582	51	12	.	.	PUNCT
admet-2582	52	1	samples	sample	NOUN
admet-2582	52	2	from	from	ADP
admet-2582	52	3	the	the	DET
admet-2582	52	4	following	follow	VERB
admet-2582	52	5	23	23	NUM
admet-2582	52	6	tissues	tissue	NOUN
admet-2582	52	7	/	/	SYM
admet-2582	52	8	body	body	NOUN
admet-2582	52	9	fluids	fluid	NOUN
admet-2582	52	10	were	be	AUX
admet-2582	52	11	collected	collect	VERB
admet-2582	52	12	,	,	PUNCT
admet-2582	52	13	including	include	VERB
admet-2582	52	14	urine	urine	NOUN
admet-2582	52	15	,	,	PUNCT
admet-2582	52	16	serum	serum	NOUN
admet-2582	52	17	,	,	PUNCT
admet-2582	52	18	brain	brain	NOUN
admet-2582	52	19	,	,	PUNCT
admet-2582	52	20	tumour	tumour	NOUN
admet-2582	52	21	tissue	tissue	NOUN
admet-2582	52	22	,	,	PUNCT
admet-2582	52	23	and	and	CCONJ
admet-2582	52	24	so	so	ADV
admet-2582	52	25	on	on	ADV
admet-2582	52	26	.	.	PUNCT
admet-2582	53	1	the	the	DET
admet-2582	53	2	total	total	ADJ
admet-2582	53	3	gamma	gamma	NOUN
admet-2582	53	4	radioactivity	radioactivity	NOUN
admet-2582	53	5	was	be	AUX
admet-2582	53	6	measured	measure	VERB
admet-2582	53	7	in	in	ADP
admet-2582	53	8	each	each	DET
admet-2582	53	9	tissue	tissue	NOUN
admet-2582	53	10	.	.	PUNCT
admet-2582	54	1	an	an	DET
admet-2582	54	2	equal	equal	ADJ
admet-2582	54	3	volume	volume	NOUN
admet-2582	54	4	of	of	ADP
admet-2582	54	5	20	20	NUM
admet-2582	54	6	%	%	NOUN
admet-2582	54	7	trichloroacetic	trichloroacetic	ADJ
admet-2582	54	8	acid	acid	NOUN
admet-2582	54	9	(	(	PUNCT
admet-2582	54	10	tca	tca	PROPN
admet-2582	54	11	)	)	PUNCT
admet-2582	54	12	was	be	AUX
admet-2582	54	13	added	add	VERB
admet-2582	54	14	to	to	PART
admet-2582	54	15	precipitate	precipitate	VERB
admet-2582	54	16	the	the	DET
admet-2582	54	17	proteins	protein	NOUN
admet-2582	54	18	(	(	PUNCT
admet-2582	54	19	final	final	ADJ
admet-2582	54	20	concentration	concentration	NOUN
admet-2582	54	21	=	=	SYM
admet-2582	54	22	10	10	NUM
admet-2582	54	23	%	%	NOUN
admet-2582	54	24	)	)	PUNCT
admet-2582	54	25	.	.	PUNCT
admet-2582	55	1	the	the	DET
admet-2582	55	2	gamma	gamma	PROPN
admet-2582	55	3	radioactivity	radioactivity	NOUN
admet-2582	55	4	in	in	ADP
admet-2582	55	5	the	the	DET
admet-2582	55	6	tca	tca	PROPN
admet-2582	55	7	precipitate	precipitate	NOUN
admet-2582	55	8	of	of	ADP
admet-2582	55	9	each	each	DET
admet-2582	55	10	tissue	tissue	NOUN
admet-2582	55	11	was	be	AUX
admet-2582	55	12	measured	measure	VERB
admet-2582	55	13	after	after	SCONJ
admet-2582	55	14	the	the	DET
admet-2582	55	15	samples	sample	NOUN
admet-2582	55	16	were	be	AUX
admet-2582	55	17	centrifuged	centrifuge	VERB
admet-2582	55	18	and	and	CCONJ
admet-2582	55	19	the	the	DET
admet-2582	55	20	supernatant	supernatant	NOUN
admet-2582	55	21	was	be	AUX
admet-2582	55	22	removed	remove	VERB
admet-2582	55	23	.	.	PUNCT
admet-2582	56	1	the	the	DET
admet-2582	56	2	radioactive	radioactive	ADJ
admet-2582	56	3	concentration	concentration	NOUN
admet-2582	56	4	in	in	ADP
admet-2582	56	5	tissue	tissue	NOUN
admet-2582	56	6	/	/	SYM
admet-2582	56	7	body	body	NOUN
admet-2582	56	8	fluid	fluid	NOUN
admet-2582	56	9	was	be	AUX
admet-2582	56	10	expressed	express	VERB
admet-2582	56	11	as	as	ADP
admet-2582	56	12	µg	µg	ADP
admet-2582	56	13	equivalents	equivalent	NOUN
admet-2582	56	14	per	per	ADP
admet-2582	56	15	gram	gram	NOUN
admet-2582	56	16	of	of	ADP
admet-2582	56	17	fresh	fresh	ADJ
admet-2582	56	18	wet	wet	ADJ
admet-2582	56	19	weight	weight	NOUN
admet-2582	56	20	(	(	PUNCT
admet-2582	56	21	μg·eqv·g-1	μg·eqv·g-1	NOUN
admet-2582	56	22	)	)	PUNCT
admet-2582	56	23	for	for	ADP
admet-2582	56	24	tissues	tissue	NOUN
admet-2582	56	25	or	or	CCONJ
admet-2582	56	26	per	per	ADP
admet-2582	56	27	ml	ml	NOUN
admet-2582	56	28	for	for	ADP
admet-2582	56	29	body	body	NOUN
admet-2582	56	30	fluids	fluid	NOUN
admet-2582	56	31	(	(	PUNCT
admet-2582	56	32	μg·eqv·ml-1	μg·eqv·ml-1	NOUN
admet-2582	56	33	)	)	PUNCT
admet-2582	56	34	.	.	PUNCT
admet-2582	57	1	radioactivity	radioactivity	NOUN
admet-2582	57	2	was	be	AUX
admet-2582	57	3	investigated	investigate	VERB
admet-2582	57	4	using	use	VERB
admet-2582	57	5	the	the	DET
admet-2582	57	6	size	size	NOUN
admet-2582	57	7	-	-	PUNCT
admet-2582	57	8	exclusion	exclusion	NOUN
admet-2582	57	9	high	high	ADJ
admet-2582	57	10	-	-	PUNCT
admet-2582	57	11	performance	performance	NOUN
admet-2582	57	12	liquid	liquid	ADJ
admet-2582	57	13	chromatography	chromatography	NOUN
admet-2582	57	14	(	(	PUNCT
admet-2582	57	15	shplc	shplc	PROPN
admet-2582	57	16	)	)	PUNCT
admet-2582	57	17	and	and	CCONJ
admet-2582	57	18	radioactive	radioactive	ADJ
admet-2582	57	19	analysis	analysis	NOUN
admet-2582	57	20	.	.	PUNCT
admet-2582	58	1	the	the	DET
admet-2582	58	2	radiomatictm	radiomatictm	ADJ
admet-2582	58	3	610tr	610tr	NOUN
admet-2582	58	4	flow	flow	NOUN
admet-2582	58	5	scintillation	scintillation	NOUN
admet-2582	58	6	analyzer	analyzer	NOUN
admet-2582	58	7	(	(	PUNCT
admet-2582	58	8	packard	packard	PROPN
admet-2582	58	9	instrument	instrument	PROPN
admet-2582	58	10	co.	co.	PROPN
admet-2582	58	11	)	)	PUNCT
admet-2582	58	12	was	be	AUX
admet-2582	58	13	used	use	VERB
admet-2582	58	14	to	to	PART
admet-2582	58	15	scan	scan	VERB
admet-2582	58	16	the	the	DET
admet-2582	58	17	gamma	gamma	NOUN
admet-2582	58	18	radioactive	radioactive	ADJ
admet-2582	58	19	chromatograms	chromatogram	NOUN
admet-2582	58	20	.	.	PUNCT
admet-2582	59	1	the	the	DET
admet-2582	59	2	peaks	peak	NOUN
admet-2582	59	3	were	be	AUX
admet-2582	59	4	directly	directly	ADV
admet-2582	59	5	analysed	analyse	VERB
admet-2582	59	6	by	by	ADP
admet-2582	59	7	the	the	DET
admet-2582	59	8	flo	flo	PROPN
admet-2582	59	9	-	-	ADJ
admet-2582	59	10	one	one	NUM
admet-2582	59	11	software	software	NOUN
admet-2582	59	12	for	for	ADP
admet-2582	59	13	windows	window	NOUN
admet-2582	59	14	from	from	ADP
admet-2582	59	15	the	the	DET
admet-2582	59	16	same	same	ADJ
admet-2582	59	17	company	company	NOUN
admet-2582	59	18	.	.	PUNCT
admet-2582	60	1	tissue	tissue	NOUN
admet-2582	60	2	distribution	distribution	NOUN
admet-2582	60	3	study	study	NOUN
admet-2582	60	4	with	with	ADP
admet-2582	60	5	[	[	PUNCT
admet-2582	60	6	3h	3h	NUM
admet-2582	60	7	-	-	PUNCT
admet-2582	60	8	mmae]-rc48	mmae]-rc48	NOUN
admet-2582	60	9	-	-	PUNCT
admet-2582	60	10	adc	adc	NOUN
admet-2582	60	11	the	the	DET
admet-2582	60	12	nci	nci	PROPN
admet-2582	60	13	-	-	PUNCT
admet-2582	60	14	n87	n87	NOUN
admet-2582	60	15	tumour	tumour	NOUN
admet-2582	60	16	-	-	PUNCT
admet-2582	60	17	bearing	bear	VERB
admet-2582	60	18	nude	nude	ADJ
admet-2582	60	19	mice	mouse	NOUN
admet-2582	60	20	were	be	AUX
admet-2582	60	21	killed	kill	VERB
admet-2582	60	22	by	by	ADP
admet-2582	60	23	femoral	femoral	ADJ
admet-2582	60	24	artery	artery	NOUN
admet-2582	60	25	bleeding	bleeding	NOUN
admet-2582	60	26	and	and	CCONJ
admet-2582	60	27	twenty	twenty	NUM
admet-2582	60	28	-	-	PUNCT
admet-2582	60	29	five	five	NUM
admet-2582	60	30	tissues	tissue	NOUN
admet-2582	60	31	/	/	SYM
admet-2582	60	32	body	body	NOUN
admet-2582	60	33	fluids	fluid	NOUN
admet-2582	60	34	were	be	AUX
admet-2582	60	35	collected	collect	VERB
admet-2582	60	36	at	at	ADP
admet-2582	60	37	4	4	NUM
admet-2582	60	38	,	,	PUNCT
admet-2582	60	39	24	24	NUM
admet-2582	60	40	,	,	PUNCT
admet-2582	60	41	72	72	NUM
admet-2582	60	42	,	,	PUNCT
admet-2582	60	43	168	168	NUM
admet-2582	60	44	and	and	CCONJ
admet-2582	60	45	336	336	NUM
admet-2582	60	46	h	h	NOUN
admet-2582	60	47	after	after	ADP
admet-2582	60	48	i.v	i.v	PROPN
admet-2582	60	49	.	.	PUNCT
admet-2582	61	1	injection	injection	NOUN
admet-2582	61	2	of	of	ADP
admet-2582	61	3	12	12	NUM
admet-2582	61	4	mg	mg	NOUN
admet-2582	61	5	/	/	SYM
admet-2582	61	6	kg	kg	X
admet-2582	62	1	[	[	X
admet-2582	62	2	3h	3h	NUM
admet-2582	62	3	-	-	PUNCT
admet-2582	62	4	mmae	mmae	NOUN
admet-2582	62	5	]	]	PUNCT
admet-2582	62	6	-rc48	-rc48	PROPN
admet-2582	62	7	-	-	PUNCT
admet-2582	62	8	adc	adc	PROPN
admet-2582	62	9	.	.	PUNCT
admet-2582	63	1	all	all	DET
admet-2582	63	2	these	these	DET
admet-2582	63	3	tissues	tissue	NOUN
admet-2582	63	4	/	/	SYM
admet-2582	63	5	body	body	NOUN
admet-2582	63	6	fluids	fluid	NOUN
admet-2582	63	7	included	include	VERB
admet-2582	63	8	plasma	plasma	NOUN
admet-2582	63	9	,	,	PUNCT
admet-2582	63	10	tumour	tumour	NOUN
admet-2582	63	11	,	,	PUNCT
admet-2582	63	12	heart	heart	NOUN
admet-2582	63	13	,	,	PUNCT
admet-2582	63	14	spleen	spleen	NOUN
admet-2582	63	15	,	,	PUNCT
admet-2582	63	16	lung	lung	NOUN
admet-2582	63	17	,	,	PUNCT
admet-2582	63	18	kidney	kidney	NOUN
admet-2582	63	19	and	and	CCONJ
admet-2582	63	20	liver	liver	NOUN
admet-2582	63	21	homogenates	homogenate	NOUN
admet-2582	63	22	,	,	PUNCT
admet-2582	63	23	extracted	extract	VERB
admet-2582	63	24	with	with	ADP
admet-2582	63	25	6	6	NUM
admet-2582	63	26	times	time	NOUN
admet-2582	63	27	the	the	DET
admet-2582	63	28	volume	volume	NOUN
admet-2582	63	29	of	of	ADP
admet-2582	63	30	acetonitrile	acetonitrile	PROPN
admet-2582	63	31	(	(	PUNCT
admet-2582	63	32	acn	acn	PROPN
admet-2582	63	33	)	)	PUNCT
admet-2582	63	34	and	and	CCONJ
admet-2582	63	35	centrifuged	centrifuge	VERB
admet-2582	63	36	at	at	ADP
admet-2582	63	37	10,000	10,000	NUM
admet-2582	63	38	g	g	NOUN
admet-2582	63	39	for	for	ADP
admet-2582	63	40	10	10	NUM
admet-2582	63	41	min	min	NOUN
admet-2582	63	42	.	.	PROPN
admet-2582	63	43	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	PROPN
admet-2582	63	44	m.	m.	NOUN
admet-2582	63	45	das	das	PROPN
admet-2582	63	46	et	et	PROPN
admet-2582	63	47	al	al	PROPN
admet-2582	63	48	.	.	PROPN
admet-2582	63	49	admet	admet	PROPN
admet-2582	63	50	&	&	CCONJ
admet-2582	63	51	dmpk	dmpk	PROPN
admet-2582	63	52	13(2	13(2	PROPN
admet-2582	63	53	)	)	PUNCT
admet-2582	63	54	(	(	PUNCT
admet-2582	63	55	2025	2025	NUM
admet-2582	63	56	)	)	PUNCT
admet-2582	63	57	2582	2582	NUM
admet-2582	63	58	4	4	NUM
admet-2582	63	59	the	the	DET
admet-2582	63	60	concentration	concentration	NOUN
admet-2582	63	61	of	of	ADP
admet-2582	63	62	free	free	ADJ
admet-2582	63	63	mmae	mmae	NOUN
admet-2582	63	64	was	be	AUX
admet-2582	63	65	obtained	obtain	VERB
admet-2582	63	66	by	by	ADP
admet-2582	63	67	direct	direct	ADJ
admet-2582	63	68	measurement	measurement	NOUN
admet-2582	63	69	of	of	ADP
admet-2582	63	70	all	all	DET
admet-2582	63	71	acetonitrile	acetonitrile	ADJ
admet-2582	63	72	extracts	extract	NOUN
admet-2582	63	73	.	.	PUNCT
admet-2582	64	1	after	after	ADP
admet-2582	64	2	centrifugal	centrifugal	ADJ
admet-2582	64	3	precipitation	precipitation	NOUN
admet-2582	64	4	,	,	PUNCT
admet-2582	64	5	whole	whole	ADJ
admet-2582	64	6	blood	blood	NOUN
admet-2582	64	7	and	and	CCONJ
admet-2582	64	8	remaining	remain	VERB
admet-2582	64	9	tissue	tissue	NOUN
admet-2582	64	10	specimens	specimen	NOUN
admet-2582	64	11	were	be	AUX
admet-2582	64	12	dissolved	dissolve	VERB
admet-2582	64	13	by	by	ADP
admet-2582	64	14	heating	heat	VERB
admet-2582	64	15	in	in	ADP
admet-2582	64	16	a	a	DET
admet-2582	64	17	1	1	NUM
admet-2582	64	18	m	m	NOUN
admet-2582	64	19	koh	koh	NOUN
admet-2582	64	20	solution	solution	NOUN
admet-2582	64	21	at	at	ADP
admet-2582	64	22	90	90	NUM
admet-2582	64	23	°	°	NOUN
admet-2582	64	24	c	c	NOUN
admet-2582	64	25	and	and	CCONJ
admet-2582	64	26	the	the	DET
admet-2582	64	27	radioactivity	radioactivity	NOUN
admet-2582	64	28	content	content	NOUN
admet-2582	64	29	was	be	AUX
admet-2582	64	30	determined	determine	VERB
admet-2582	64	31	by	by	ADP
admet-2582	64	32	liquid	liquid	ADJ
admet-2582	64	33	scintillation	scintillation	NOUN
admet-2582	64	34	counting	counting	NOUN
admet-2582	64	35	.	.	PUNCT
admet-2582	65	1	radioactivity	radioactivity	NOUN
admet-2582	65	2	concentrations	concentration	NOUN
admet-2582	65	3	in	in	ADP
admet-2582	65	4	tissues	tissue	NOUN
admet-2582	65	5	/	/	SYM
admet-2582	65	6	body	body	NOUN
admet-2582	65	7	fluids	fluid	NOUN
admet-2582	65	8	were	be	AUX
admet-2582	65	9	expressed	express	VERB
admet-2582	65	10	as	as	ADP
admet-2582	65	11	microgram	microgram	ADJ
admet-2582	65	12	equivalents	equivalent	NOUN
admet-2582	65	13	per	per	ADP
admet-2582	65	14	gram	gram	NOUN
admet-2582	65	15	of	of	ADP
admet-2582	65	16	fresh	fresh	ADJ
admet-2582	65	17	wet	wet	ADJ
admet-2582	65	18	weight	weight	NOUN
admet-2582	65	19	(	(	PUNCT
admet-2582	65	20	μg·eqv·g-1	μg·eqv·g-1	NOUN
admet-2582	65	21	)	)	PUNCT
admet-2582	65	22	or	or	CCONJ
admet-2582	65	23	per	per	ADP
admet-2582	65	24	millilitre	millilitre	NOUN
admet-2582	65	25	of	of	ADP
admet-2582	65	26	body	body	NOUN
admet-2582	65	27	fluid	fluid	NOUN
admet-2582	65	28	(	(	PUNCT
admet-2582	65	29	μg·eqv·ml-1	μg·eqv·ml-1	NOUN
admet-2582	65	30	)	)	PUNCT
admet-2582	65	31	.	.	PUNCT
admet-2582	66	1	total	total	ADJ
admet-2582	66	2	radioactivity	radioactivity	NOUN
admet-2582	66	3	and	and	CCONJ
admet-2582	66	4	acn	acn	PROPN
admet-2582	66	5	extract	extract	VERB
admet-2582	66	6	radioactivity	radioactivity	NOUN
admet-2582	66	7	(	(	PUNCT
admet-2582	66	8	3h	3h	NUM
admet-2582	66	9	-	-	PUNCT
admet-2582	66	10	labelled	label	VERB
admet-2582	66	11	mmae	mmae	NOUN
admet-2582	66	12	)	)	PUNCT
admet-2582	66	13	were	be	AUX
admet-2582	66	14	determined	determine	VERB
admet-2582	66	15	using	use	VERB
admet-2582	66	16	radioactive	radioactive	ADJ
admet-2582	66	17	liquid	liquid	ADJ
admet-2582	66	18	scintillation	scintillation	NOUN
admet-2582	66	19	analyzer	analyzer	NOUN
admet-2582	66	20	.	.	PUNCT
admet-2582	67	1	125i	125i	PROPN
admet-2582	67	2	-	-	PUNCT
admet-2582	67	3	rc48	rc48	PROPN
admet-2582	67	4	-	-	PUNCT
admet-2582	67	5	adc	adc	PROPN
admet-2582	67	6	and	and	CCONJ
admet-2582	67	7	[	[	X
admet-2582	67	8	3h	3h	NUM
admet-2582	67	9	-	-	PUNCT
admet-2582	67	10	mmae]-rc48	mmae]-rc48	NOUN
admet-2582	67	11	-	-	PUNCT
admet-2582	67	12	adc	adc	NOUN
admet-2582	67	13	excretion	excretion	NOUN
admet-2582	67	14	study	study	NOUN
admet-2582	67	15	urine	urine	NOUN
admet-2582	67	16	and	and	CCONJ
admet-2582	67	17	faecal	faecal	ADJ
admet-2582	67	18	samples	sample	NOUN
admet-2582	67	19	were	be	AUX
admet-2582	67	20	collected	collect	VERB
admet-2582	67	21	from	from	ADP
admet-2582	67	22	0	0	NUM
admet-2582	67	23	to	to	ADP
admet-2582	67	24	24	24	NUM
admet-2582	67	25	h	h	NOUN
admet-2582	67	26	,	,	PUNCT
admet-2582	67	27	24	24	NUM
admet-2582	67	28	to	to	ADP
admet-2582	67	29	48	48	NUM
admet-2582	67	30	h	h	NOUN
admet-2582	67	31	,	,	PUNCT
admet-2582	67	32	...	...	PUNCT
admet-2582	67	33	,	,	PUNCT
admet-2582	67	34	to	to	ADP
admet-2582	67	35	288	288	NUM
admet-2582	67	36	to	to	PART
admet-2582	67	37	336	336	NUM
admet-2582	67	38	h	h	NOUN
admet-2582	67	39	after	after	ADP
admet-2582	67	40	intravenous	intravenous	ADJ
admet-2582	67	41	injection	injection	NOUN
admet-2582	67	42	of	of	ADP
admet-2582	67	43	12	12	NUM
admet-2582	67	44	mg	mg	NOUN
admet-2582	67	45	/kg	/kg	PUNCT
admet-2582	67	46	125i	125i	PROPN
admet-2582	67	47	-	-	PUNCT
admet-2582	67	48	rc48	rc48	PROPN
admet-2582	67	49	-	-	PUNCT
admet-2582	67	50	adc	adc	PROPN
admet-2582	67	51	in	in	ADP
admet-2582	67	52	twelve	twelve	NUM
admet-2582	67	53	male	male	ADJ
admet-2582	67	54	and	and	CCONJ
admet-2582	67	55	female	female	ADJ
admet-2582	67	56	tumour	tumour	NOUN
admet-2582	67	57	-	-	PUNCT
admet-2582	67	58	bearing	bear	VERB
admet-2582	67	59	nude	nude	ADJ
admet-2582	67	60	mice	mouse	NOUN
admet-2582	67	61	.	.	PUNCT
admet-2582	68	1	urine	urine	NOUN
admet-2582	68	2	and	and	CCONJ
admet-2582	68	3	faecal	faecal	ADJ
admet-2582	68	4	samples	sample	NOUN
admet-2582	68	5	also	also	ADV
admet-2582	68	6	were	be	AUX
admet-2582	68	7	collected	collect	VERB
admet-2582	68	8	at	at	ADP
admet-2582	68	9	0	0	NUM
admet-2582	68	10	to	to	PART
admet-2582	68	11	8	8	NUM
admet-2582	68	12	h	h	NOUN
admet-2582	68	13	,	,	PUNCT
admet-2582	68	14	8	8	NUM
admet-2582	68	15	to	to	PART
admet-2582	68	16	24	24	NUM
admet-2582	68	17	h	h	NOUN
admet-2582	68	18	,	,	PUNCT
admet-2582	68	19	…	…	PUNCT
admet-2582	68	20	,	,	PUNCT
admet-2582	68	21	until	until	ADP
admet-2582	68	22	336	336	NUM
admet-2582	68	23	to	to	PART
admet-2582	68	24	504	504	NUM
admet-2582	68	25	h	h	NOUN
admet-2582	68	26	after	after	ADP
admet-2582	68	27	intravenous	intravenous	ADJ
admet-2582	68	28	administration	administration	NOUN
admet-2582	68	29	of	of	ADP
admet-2582	68	30	8	8	NUM
admet-2582	68	31	mg	mg	NUM
admet-2582	68	32	/	/	SYM
admet-2582	68	33	kg	kg	X
admet-2582	69	1	[	[	X
admet-2582	69	2	3h	3h	NUM
admet-2582	69	3	-	-	PUNCT
admet-2582	69	4	mmae]-rc48	mmae]-rc48	NOUN
admet-2582	69	5	-	-	PUNCT
admet-2582	69	6	adc	adc	NOUN
admet-2582	69	7	to	to	ADP
admet-2582	69	8	six	six	NUM
admet-2582	69	9	intact	intact	ADJ
admet-2582	69	10	rats	rat	NOUN
admet-2582	69	11	of	of	ADP
admet-2582	69	12	both	both	DET
admet-2582	69	13	sexes	sex	NOUN
admet-2582	69	14	.	.	PUNCT
admet-2582	70	1	the	the	DET
admet-2582	70	2	gamma	gamma	PROPN
admet-2582	70	3	radioactivity	radioactivity	NOUN
admet-2582	70	4	per	per	ADP
admet-2582	70	5	unit	unit	NOUN
admet-2582	70	6	volume	volume	NOUN
admet-2582	70	7	was	be	AUX
admet-2582	70	8	measured	measure	VERB
admet-2582	70	9	.	.	PUNCT
admet-2582	71	1	the	the	DET
admet-2582	71	2	amount	amount	NOUN
admet-2582	71	3	of	of	ADP
admet-2582	71	4	the	the	DET
admet-2582	71	5	radioactivity	radioactivity	NOUN
admet-2582	71	6	excreted	excrete	VERB
admet-2582	71	7	as	as	ADP
admet-2582	71	8	a	a	DET
admet-2582	71	9	percentage	percentage	NOUN
admet-2582	71	10	of	of	ADP
admet-2582	71	11	the	the	DET
admet-2582	71	12	administered	administer	VERB
admet-2582	71	13	radioactivity	radioactivity	NOUN
admet-2582	71	14	was	be	AUX
admet-2582	71	15	calculated	calculate	VERB
admet-2582	71	16	.	.	PUNCT
admet-2582	72	1	the	the	DET
admet-2582	72	2	abdominal	abdominal	ADJ
admet-2582	72	3	wall	wall	NOUN
admet-2582	72	4	of	of	ADP
admet-2582	72	5	rats	rat	NOUN
admet-2582	72	6	was	be	AUX
admet-2582	72	7	dissected	dissect	VERB
admet-2582	72	8	under	under	ADP
admet-2582	72	9	anaesthesia	anaesthesia	NOUN
admet-2582	72	10	and	and	CCONJ
admet-2582	72	11	sodium	sodium	NOUN
admet-2582	72	12	pentobarbital	pentobarbital	NOUN
admet-2582	72	13	-	-	PUNCT
admet-2582	72	14	assisted	assist	VERB
admet-2582	72	15	anaesthesia	anaesthesia	NOUN
admet-2582	72	16	,	,	PUNCT
admet-2582	72	17	and	and	CCONJ
admet-2582	72	18	the	the	DET
admet-2582	72	19	common	common	ADJ
admet-2582	72	20	bile	bile	NOUN
admet-2582	72	21	duct	duct	NOUN
admet-2582	72	22	was	be	AUX
admet-2582	72	23	isolated	isolate	VERB
admet-2582	72	24	.	.	PUNCT
admet-2582	73	1	the	the	DET
admet-2582	73	2	distal	distal	ADJ
admet-2582	73	3	end	end	NOUN
admet-2582	73	4	of	of	ADP
admet-2582	73	5	the	the	DET
admet-2582	73	6	bile	bile	NOUN
admet-2582	73	7	duct	duct	NOUN
admet-2582	73	8	was	be	AUX
admet-2582	73	9	ligated	ligate	VERB
admet-2582	73	10	,	,	PUNCT
admet-2582	73	11	and	and	CCONJ
admet-2582	73	12	a	a	DET
admet-2582	73	13	drain	drain	NOUN
admet-2582	73	14	was	be	AUX
admet-2582	73	15	inserted	insert	VERB
admet-2582	73	16	at	at	ADP
admet-2582	73	17	the	the	DET
admet-2582	73	18	proximal	proximal	ADJ
admet-2582	73	19	end	end	NOUN
admet-2582	73	20	to	to	PART
admet-2582	73	21	drain	drain	VERB
admet-2582	73	22	the	the	DET
admet-2582	73	23	bile	bile	NOUN
admet-2582	73	24	.	.	PUNCT
admet-2582	74	1	each	each	DET
admet-2582	74	2	rat	rat	NOUN
admet-2582	74	3	received	receive	VERB
admet-2582	74	4	a	a	DET
admet-2582	74	5	dose	dose	NOUN
admet-2582	74	6	of	of	ADP
admet-2582	74	7	8	8	NUM
admet-2582	74	8	mg	mg	NUM
admet-2582	74	9	/	/	SYM
admet-2582	74	10	kg	kg	NOUN
admet-2582	74	11	125i	125i	PROPN
admet-2582	74	12	-	-	PUNCT
admet-2582	74	13	rc48	rc48	PROPN
admet-2582	74	14	-	-	PUNCT
admet-2582	74	15	adc	adc	PROPN
admet-2582	74	16	or	or	CCONJ
admet-2582	74	17	[	[	PUNCT
admet-2582	74	18	3h	3h	NUM
admet-2582	74	19	-	-	PUNCT
admet-2582	74	20	mmae]-rc48	mmae]-rc48	NOUN
admet-2582	74	21	-	-	PUNCT
admet-2582	74	22	adc	adc	NOUN
admet-2582	74	23	via	via	ADP
admet-2582	74	24	intravenous	intravenous	ADJ
admet-2582	74	25	injection	injection	NOUN
admet-2582	74	26	on	on	ADP
admet-2582	74	27	the	the	DET
admet-2582	74	28	tail	tail	NOUN
admet-2582	74	29	.	.	PUNCT
admet-2582	75	1	bile	bile	NOUN
admet-2582	75	2	samples	sample	NOUN
admet-2582	75	3	were	be	AUX
admet-2582	75	4	collected	collect	VERB
admet-2582	75	5	at	at	ADP
admet-2582	75	6	1	1	NUM
admet-2582	75	7	,	,	PUNCT
admet-2582	75	8	2	2	NUM
admet-2582	75	9	,	,	PUNCT
admet-2582	75	10	3	3	NUM
admet-2582	75	11	,	,	PUNCT
admet-2582	75	12	5	5	NUM
admet-2582	75	13	,	,	PUNCT
admet-2582	75	14	8	8	NUM
admet-2582	75	15	,	,	PUNCT
admet-2582	75	16	12	12	NUM
admet-2582	75	17	and	and	CCONJ
admet-2582	75	18	24	24	NUM
admet-2582	75	19	h	h	NOUN
admet-2582	75	20	or	or	CCONJ
admet-2582	75	21	4	4	NUM
admet-2582	75	22	,	,	PUNCT
admet-2582	75	23	8	8	NUM
admet-2582	75	24	,	,	PUNCT
admet-2582	75	25	24	24	NUM
admet-2582	75	26	,	,	PUNCT
admet-2582	75	27	48	48	NUM
admet-2582	75	28	and	and	CCONJ
admet-2582	75	29	72	72	NUM
admet-2582	75	30	h	h	NOUN
admet-2582	75	31	after	after	ADP
admet-2582	75	32	the	the	DET
admet-2582	75	33	dose	dose	NOUN
admet-2582	75	34	.	.	PUNCT
admet-2582	76	1	the	the	DET
admet-2582	76	2	gamma	gamma	PROPN
admet-2582	76	3	radioactivity	radioactivity	NOUN
admet-2582	76	4	per	per	ADP
admet-2582	76	5	hour	hour	NOUN
admet-2582	76	6	in	in	ADP
admet-2582	76	7	the	the	DET
admet-2582	76	8	bile	bile	NOUN
admet-2582	76	9	was	be	AUX
admet-2582	76	10	measured	measure	VERB
admet-2582	76	11	.	.	PUNCT
admet-2582	77	1	the	the	DET
admet-2582	77	2	24	24	NUM
admet-2582	77	3	-	-	PUNCT
admet-2582	77	4	hour	hour	NOUN
admet-2582	77	5	cumulative	cumulative	ADJ
admet-2582	77	6	excreted	excrete	VERB
admet-2582	77	7	radioactivity	radioactivity	NOUN
admet-2582	77	8	was	be	AUX
admet-2582	77	9	calculated	calculate	VERB
admet-2582	77	10	as	as	ADP
admet-2582	77	11	a	a	DET
admet-2582	77	12	percentage	percentage	NOUN
admet-2582	77	13	of	of	ADP
admet-2582	77	14	the	the	DET
admet-2582	77	15	total	total	ADJ
admet-2582	77	16	administered	administer	VERB
admet-2582	77	17	radioactivity	radioactivity	NOUN
admet-2582	77	18	and	and	CCONJ
admet-2582	77	19	the	the	DET
admet-2582	77	20	changes	change	NOUN
admet-2582	77	21	over	over	ADP
admet-2582	77	22	time	time	NOUN
admet-2582	77	23	were	be	AUX
admet-2582	77	24	examined	examine	VERB
admet-2582	77	25	.	.	PUNCT
admet-2582	78	1	catabolite	catabolite	ADJ
admet-2582	78	2	profiling	profiling	NOUN
admet-2582	78	3	and	and	CCONJ
admet-2582	78	4	identification	identification	NOUN
admet-2582	78	5	with	with	ADP
admet-2582	78	6	[	[	X
admet-2582	78	7	3h]-mmae	3h]-mmae	NUM
admet-2582	78	8	disitamab	disitamab	NOUN
admet-2582	78	9	vedotin	vedotin	NOUN
admet-2582	78	10	in	in	ADP
admet-2582	78	11	rats	rat	NOUN
admet-2582	78	12	the	the	DET
admet-2582	78	13	bile	bile	NOUN
admet-2582	78	14	urine	urine	NOUN
admet-2582	78	15	and	and	CCONJ
admet-2582	78	16	faecal	faecal	ADJ
admet-2582	78	17	homogenate	homogenate	NOUN
admet-2582	78	18	samples	sample	NOUN
admet-2582	78	19	used	use	VERB
admet-2582	78	20	for	for	ADP
admet-2582	78	21	metabolic	metabolic	NOUN
admet-2582	78	22	research	research	NOUN
admet-2582	78	23	in	in	ADP
admet-2582	78	24	this	this	DET
admet-2582	78	25	study	study	NOUN
admet-2582	78	26	were	be	AUX
admet-2582	78	27	all	all	ADV
admet-2582	78	28	from	from	ADP
admet-2582	78	29	the	the	DET
admet-2582	78	30	excretion	excretion	NOUN
admet-2582	78	31	studies	study	NOUN
admet-2582	78	32	of	of	ADP
admet-2582	78	33	rats	rat	NOUN
admet-2582	78	34	after	after	ADP
admet-2582	78	35	a	a	DET
admet-2582	78	36	single	single	ADJ
admet-2582	78	37	intravenous	intravenous	ADJ
admet-2582	78	38	administration	administration	NOUN
admet-2582	78	39	of	of	ADP
admet-2582	78	40	8	8	NUM
admet-2582	78	41	mg/200	mg/200	PROPN
admet-2582	78	42	ci	ci	PROPN
admet-2582	78	43	/	/	SYM
admet-2582	78	44	kg	kg	X
admet-2582	79	1	[	[	X
admet-2582	79	2	3h	3h	NUM
admet-2582	79	3	-	-	PUNCT
admet-2582	79	4	mmae	mmae	NOUN
admet-2582	79	5	]	]	PUNCT
admet-2582	79	6	rc48	rc48	PROPN
admet-2582	79	7	-	-	PUNCT
admet-2582	79	8	adc	adc	PROPN
admet-2582	79	9	,	,	PUNCT
admet-2582	79	10	and	and	CCONJ
admet-2582	79	11	the	the	DET
admet-2582	79	12	plasma	plasma	NOUN
admet-2582	79	13	and	and	CCONJ
admet-2582	79	14	tumour	tumour	NOUN
admet-2582	79	15	tissue	tissue	NOUN
admet-2582	79	16	homogenate	homogenate	NOUN
admet-2582	79	17	samples	sample	NOUN
admet-2582	79	18	were	be	AUX
admet-2582	79	19	from	from	ADP
admet-2582	79	20	a	a	DET
admet-2582	79	21	single	single	ADJ
admet-2582	79	22	intravenous	intravenous	ADJ
admet-2582	79	23	administration	administration	NOUN
admet-2582	79	24	of	of	ADP
admet-2582	79	25	12	12	NUM
admet-2582	79	26	mg/200	mg/200	NOUN
admet-2582	79	27	of	of	ADP
admet-2582	79	28	tumour	tumour	NOUN
admet-2582	79	29	-	-	PUNCT
admet-2582	79	30	bearing	bear	VERB
admet-2582	79	31	mice	mice	NOUN
admet-2582	79	32	tissue	tissue	NOUN
admet-2582	79	33	distribution	distribution	NOUN
admet-2582	79	34	after	after	ADP
admet-2582	79	35	[	[	PUNCT
admet-2582	79	36	3h	3h	NUM
admet-2582	79	37	-	-	PUNCT
admet-2582	79	38	mmae]rc48	mmae]rc48	PRON
admet-2582	79	39	-	-	PUNCT
admet-2582	79	40	adc	adc	NOUN
admet-2582	79	41	of	of	ADP
admet-2582	79	42	ci	ci	PROPN
admet-2582	79	43	/	/	SYM
admet-2582	79	44	kg	kg	PROPN
admet-2582	79	45	.	.	PUNCT
admet-2582	80	1	to	to	PART
admet-2582	80	2	characterize	characterize	VERB
admet-2582	80	3	the	the	DET
admet-2582	80	4	catabolic	catabolic	ADJ
admet-2582	80	5	profile	profile	NOUN
admet-2582	80	6	of	of	ADP
admet-2582	80	7	[	[	X
admet-2582	80	8	3h]-mmae	3h]-mmae	NUM
admet-2582	80	9	dv	dv	PROPN
admet-2582	80	10	conjugated	conjugate	VERB
admet-2582	80	11	with	with	ADP
admet-2582	80	12	plasma	plasma	NOUN
admet-2582	80	13	,	,	PUNCT
admet-2582	80	14	bile	bile	NOUN
admet-2582	80	15	,	,	PUNCT
admet-2582	80	16	urine	urine	NOUN
admet-2582	80	17	,	,	PUNCT
admet-2582	80	18	faeces	faece	NOUN
admet-2582	80	19	,	,	PUNCT
admet-2582	80	20	and	and	CCONJ
admet-2582	80	21	tumour	tumour	NOUN
admet-2582	80	22	tissue	tissue	NOUN
admet-2582	80	23	,	,	PUNCT
admet-2582	80	24	samples	sample	NOUN
admet-2582	80	25	were	be	AUX
admet-2582	80	26	investigated	investigate	VERB
admet-2582	80	27	using	use	VERB
admet-2582	80	28	a	a	DET
admet-2582	80	29	shimadzu	shimadzu	ADJ
admet-2582	80	30	lc-2030c	lc-2030c	NOUN
admet-2582	80	31	3d	3d	NOUN
admet-2582	80	32	(	(	PUNCT
admet-2582	80	33	shimadzu	shimadzu	ADJ
admet-2582	80	34	company	company	NOUN
admet-2582	80	35	,	,	PUNCT
admet-2582	80	36	jp	jp	NOUN
admet-2582	80	37	)	)	PUNCT
admet-2582	80	38	coupled	couple	VERB
admet-2582	80	39	with	with	ADP
admet-2582	80	40	an	an	DET
admet-2582	80	41	ltq	ltq	ADJ
admet-2582	80	42	orbitrap	orbitrap	NOUN
admet-2582	80	43	xl	xl	PROPN
admet-2582	80	44	system	system	NOUN
admet-2582	80	45	(	(	PUNCT
admet-2582	80	46	thermo	thermo	NOUN
admet-2582	80	47	scientific	scientific	NOUN
admet-2582	80	48	,	,	PUNCT
admet-2582	80	49	usa	usa	PROPN
admet-2582	80	50	)	)	PUNCT
admet-2582	80	51	and	and	CCONJ
admet-2582	80	52	an	an	DET
admet-2582	80	53	online	online	ADJ
admet-2582	80	54	-	-	PUNCT
admet-2582	80	55	model	model	NOUN
admet-2582	80	56	3	3	NUM
admet-2582	80	57	radio	radio	NOUN
admet-2582	80	58	detector	detector	NOUN
admet-2582	80	59	(	(	PUNCT
admet-2582	80	60	america	america	PROPN
admet-2582	80	61	in	in	ADP
admet-2582	80	62	motion	motion	NOUN
admet-2582	80	63	,	,	PUNCT
admet-2582	80	64	usa	usa	PROPN
admet-2582	80	65	)	)	PUNCT
admet-2582	80	66	for	for	ADP
admet-2582	80	67	radio	radio	NOUN
admet-2582	80	68	profiling	profiling	NOUN
admet-2582	80	69	.	.	PUNCT
admet-2582	81	1	the	the	DET
admet-2582	81	2	significant	significant	ADJ
admet-2582	81	3	radioactive	radioactive	ADJ
admet-2582	81	4	metabolites	metabolite	NOUN
admet-2582	81	5	and	and	CCONJ
admet-2582	81	6	structure	structure	NOUN
admet-2582	81	7	of	of	ADP
admet-2582	81	8	metabolites	metabolite	NOUN
admet-2582	81	9	were	be	AUX
admet-2582	81	10	identified	identify	VERB
admet-2582	81	11	and	and	CCONJ
admet-2582	81	12	analysed	analyse	VERB
admet-2582	81	13	by	by	ADP
admet-2582	81	14	lc	lc	PROPN
admet-2582	81	15	/	/	SYM
admet-2582	81	16	ram	ram	NOUN
admet-2582	81	17	/	/	SYM
admet-2582	81	18	ms	ms	NOUN
admet-2582	81	19	method	method	NOUN
admet-2582	81	20	.	.	PUNCT
admet-2582	82	1	the	the	DET
admet-2582	82	2	structural	structural	ADJ
admet-2582	82	3	analysis	analysis	NOUN
admet-2582	82	4	of	of	ADP
admet-2582	82	5	all	all	DET
admet-2582	82	6	metabolites	metabolite	NOUN
admet-2582	82	7	was	be	AUX
admet-2582	82	8	based	base	VERB
admet-2582	82	9	on	on	ADP
admet-2582	82	10	the	the	DET
admet-2582	82	11	metabolic	metabolic	NOUN
admet-2582	82	12	pathway	pathway	NOUN
admet-2582	82	13	and	and	CCONJ
admet-2582	82	14	relative	relative	ADJ
admet-2582	82	15	retention	retention	NOUN
admet-2582	82	16	time	time	NOUN
admet-2582	82	17	of	of	ADP
admet-2582	82	18	hplc	hplc	NOUN
admet-2582	82	19	.	.	PUNCT
admet-2582	83	1	chromatographic	chromatographic	ADJ
admet-2582	83	2	separation	separation	NOUN
admet-2582	83	3	was	be	AUX
admet-2582	83	4	performed	perform	VERB
admet-2582	83	5	on	on	ADP
admet-2582	83	6	a	a	DET
admet-2582	83	7	c18	c18	NOUN
admet-2582	83	8	column	column	NOUN
admet-2582	83	9	(	(	PUNCT
admet-2582	83	10	150×4.6	150×4.6	NOUN
admet-2582	83	11	mm	mm	PROPN
admet-2582	83	12	,	,	PUNCT
admet-2582	83	13	3.0	3.0	NUM
admet-2582	83	14	μm	μm	NOUN
admet-2582	83	15	particle	particle	NOUN
admet-2582	83	16	size	size	NOUN
admet-2582	83	17	,	,	PUNCT
admet-2582	83	18	ace	ace	NOUN
admet-2582	83	19	,	,	PUNCT
admet-2582	83	20	uk	uk	PROPN
admet-2582	83	21	)	)	PUNCT
admet-2582	83	22	with	with	ADP
admet-2582	83	23	mobile	mobile	ADJ
admet-2582	83	24	phases	phase	NOUN
admet-2582	83	25	a	a	DET
admet-2582	83	26	(	(	PUNCT
admet-2582	83	27	0.4	0.4	NUM
admet-2582	83	28	%	%	NOUN
admet-2582	83	29	formic	formic	NOUN
admet-2582	83	30	acid	acid	NOUN
admet-2582	83	31	in	in	ADP
admet-2582	83	32	the	the	DET
admet-2582	83	33	water	water	NOUN
admet-2582	83	34	was	be	AUX
admet-2582	83	35	adjusted	adjust	VERB
admet-2582	83	36	to	to	ADP
admet-2582	83	37	ph	ph	PROPN
admet-2582	83	38	3.2	3.2	NUM
admet-2582	83	39	with	with	ADP
admet-2582	83	40	nh4oh	nh4oh	NUM
admet-2582	83	41	)	)	PUNCT
admet-2582	83	42	and	and	CCONJ
admet-2582	83	43	b	b	X
admet-2582	83	44	(	(	PUNCT
admet-2582	83	45	acetonitrile	acetonitrile	NOUN
admet-2582	83	46	)	)	PUNCT
admet-2582	83	47	at	at	ADP
admet-2582	83	48	a	a	DET
admet-2582	83	49	constant	constant	ADJ
admet-2582	83	50	flow	flow	NOUN
admet-2582	83	51	rate	rate	NOUN
admet-2582	83	52	of	of	ADP
admet-2582	83	53	0.7	0.7	NUM
admet-2582	83	54	ml	ml	NOUN
admet-2582	83	55	/	/	SYM
admet-2582	83	56	min	min	NOUN
admet-2582	83	57	.	.	PUNCT
admet-2582	84	1	the	the	DET
admet-2582	84	2	gradient	gradient	NOUN
admet-2582	84	3	was	be	AUX
admet-2582	84	4	as	as	SCONJ
admet-2582	84	5	follows	follow	VERB
admet-2582	84	6	:	:	PUNCT
admet-2582	84	7	initial	initial	ADJ
admet-2582	84	8	holding	holding	NOUN
admet-2582	84	9	at	at	ADP
admet-2582	84	10	0	0	NUM
admet-2582	84	11	%	%	NOUN
admet-2582	84	12	b	b	NOUN
admet-2582	84	13	for	for	ADP
admet-2582	84	14	3	3	NUM
admet-2582	84	15	min	min	NOUN
admet-2582	84	16	,	,	PUNCT
admet-2582	84	17	increased	increase	VERB
admet-2582	84	18	to	to	ADP
admet-2582	84	19	35	35	NUM
admet-2582	84	20	%	%	NOUN
admet-2582	84	21	b	b	NOUN
admet-2582	84	22	at	at	ADP
admet-2582	84	23	30	30	NUM
admet-2582	84	24	min	min	NOUN
admet-2582	84	25	,	,	PUNCT
admet-2582	84	26	holding	hold	VERB
admet-2582	84	27	at	at	ADP
admet-2582	84	28	35	35	NUM
admet-2582	84	29	%	%	NOUN
admet-2582	84	30	b	b	NOUN
admet-2582	84	31	until	until	ADP
admet-2582	84	32	45	45	NUM
admet-2582	84	33	min	min	NOUN
admet-2582	84	34	,	,	PUNCT
admet-2582	84	35	100	100	NUM
admet-2582	84	36	%	%	NOUN
admet-2582	84	37	b	b	NOUN
admet-2582	84	38	at	at	ADP
admet-2582	84	39	55	55	NUM
admet-2582	84	40	min	min	NOUN
admet-2582	84	41	,	,	PUNCT
admet-2582	84	42	holding	hold	VERB
admet-2582	84	43	at	at	ADP
admet-2582	84	44	100	100	NUM
admet-2582	84	45	%	%	NOUN
admet-2582	84	46	b	b	PROPN
admet-2582	84	47	until	until	ADP
admet-2582	84	48	58	58	NUM
admet-2582	84	49	min	min	NOUN
admet-2582	84	50	,	,	PUNCT
admet-2582	84	51	decreasing	decrease	VERB
admet-2582	84	52	to	to	ADP
admet-2582	84	53	0	0	NUM
admet-2582	84	54	%	%	NOUN
admet-2582	84	55	b	b	NOUN
admet-2582	84	56	at	at	ADP
admet-2582	84	57	60	60	NUM
admet-2582	84	58	min	min	NOUN
admet-2582	84	59	,	,	PUNCT
admet-2582	84	60	and	and	CCONJ
admet-2582	84	61	then	then	ADV
admet-2582	84	62	column	column	NOUN
admet-2582	84	63	re	re	NOUN
admet-2582	84	64	-	-	NOUN
admet-2582	84	65	equilibration	equilibration	NOUN
admet-2582	84	66	until	until	ADP
admet-2582	84	67	72	72	NUM
admet-2582	84	68	min	min	NOUN
admet-2582	84	69	.	.	PUNCT
admet-2582	85	1	the	the	DET
admet-2582	85	2	flow	flow	NOUN
admet-2582	85	3	was	be	AUX
admet-2582	85	4	split	split	VERB
admet-2582	85	5	4:1	4:1	NUM
admet-2582	85	6	postcolumn	postcolumn	NOUN
admet-2582	85	7	for	for	ADP
admet-2582	85	8	the	the	DET
admet-2582	85	9	radio	radio	NOUN
admet-2582	85	10	measurements	measurement	NOUN
admet-2582	85	11	and	and	CCONJ
admet-2582	85	12	mass	mass	ADJ
admet-2582	85	13	spectrometry	spectrometry	NOUN
admet-2582	85	14	.	.	PUNCT
admet-2582	86	1	results	result	NOUN
admet-2582	86	2	and	and	CCONJ
admet-2582	86	3	discussion	discussion	NOUN
admet-2582	86	4	pharmacokinetic	pharmacokinetic	ADJ
admet-2582	86	5	profile	profile	NOUN
admet-2582	86	6	of	of	ADP
admet-2582	86	7	rc48	rc48	PROPN
admet-2582	86	8	-	-	PUNCT
admet-2582	86	9	adc	adc	PROPN
admet-2582	86	10	and	and	CCONJ
admet-2582	86	11	mmae	mmae	NOUN
admet-2582	86	12	in	in	ADP
admet-2582	86	13	rats	rat	NOUN
admet-2582	86	14	the	the	DET
admet-2582	86	15	mean	mean	ADJ
admet-2582	86	16	serum	serum	NOUN
admet-2582	86	17	concentration	concentration	NOUN
admet-2582	86	18	-	-	PUNCT
admet-2582	86	19	time	time	NOUN
admet-2582	86	20	curves	curve	NOUN
admet-2582	86	21	of	of	ADP
admet-2582	86	22	total	total	ADJ
admet-2582	86	23	antibody	antibody	NOUN
admet-2582	86	24	(	(	PUNCT
admet-2582	86	25	ta	ta	NOUN
admet-2582	86	26	)	)	PUNCT
admet-2582	86	27	,	,	PUNCT
admet-2582	86	28	conjugated	conjugate	VERB
admet-2582	86	29	antibody	antibody	NOUN
admet-2582	86	30	(	(	PUNCT
admet-2582	86	31	ca	ca	NOUN
admet-2582	86	32	)	)	PUNCT
admet-2582	86	33	,	,	PUNCT
admet-2582	86	34	free	free	ADJ
admet-2582	86	35	mmae	mmae	NOUN
admet-2582	86	36	(	(	PUNCT
admet-2582	86	37	fm	fm	NOUN
admet-2582	86	38	)	)	PUNCT
admet-2582	86	39	in	in	ADP
admet-2582	86	40	rats	rat	NOUN
admet-2582	86	41	in	in	ADP
admet-2582	86	42	different	different	ADJ
admet-2582	86	43	administration	administration	NOUN
admet-2582	86	44	groups	group	NOUN
admet-2582	86	45	are	be	AUX
admet-2582	86	46	shown	show	VERB
admet-2582	86	47	in	in	ADP
admet-2582	86	48	figure	figure	NOUN
admet-2582	86	49	2	2	NUM
admet-2582	86	50	.	.	PUNCT
admet-2582	87	1	the	the	DET
admet-2582	87	2	corresponding	correspond	VERB
admet-2582	87	3	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	87	4	(	(	PUNCT
admet-2582	87	5	pk	pk	NOUN
admet-2582	87	6	)	)	PUNCT
admet-2582	87	7	parameters	parameter	NOUN
admet-2582	87	8	of	of	ADP
admet-2582	87	9	ta	ta	PROPN
admet-2582	87	10	,	,	PUNCT
admet-2582	87	11	ca	ca	PRON
admet-2582	87	12	and	and	CCONJ
admet-2582	87	13	fm	fm	PROPN
admet-2582	87	14	are	be	AUX
admet-2582	87	15	presented	present	VERB
admet-2582	87	16	in	in	ADP
admet-2582	87	17	table	table	NOUN
admet-2582	87	18	1	1	NUM
admet-2582	87	19	.	.	PUNCT
admet-2582	88	1	after	after	SCONJ
admet-2582	88	2	a	a	DET
admet-2582	88	3	single	single	ADJ
admet-2582	88	4	iv	iv	NUM
admet-2582	88	5	administration	administration	NOUN
admet-2582	88	6	of	of	ADP
admet-2582	88	7	rc48	rc48	PROPN
admet-2582	88	8	-	-	PUNCT
admet-2582	88	9	adc	adc	PROPN
admet-2582	88	10	at	at	ADP
admet-2582	88	11	4	4	NUM
admet-2582	88	12	to	to	PART
admet-2582	88	13	admet	admet	PROPN
admet-2582	88	14	&	&	CCONJ
admet-2582	88	15	dmpk	dmpk	PROPN
admet-2582	88	16	13(2	13(2	PROPN
admet-2582	88	17	)	)	PUNCT
admet-2582	88	18	(	(	PUNCT
admet-2582	88	19	2025	2025	NUM
admet-2582	88	20	)	)	PUNCT
admet-2582	88	21	2582	2582	NUM
admet-2582	88	22	disitamab	disitamab	VERB
admet-2582	88	23	vedotin	vedotin	ADJ
admet-2582	88	24	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	88	25	,	,	PUNCT
admet-2582	88	26	distribution	distribution	NOUN
admet-2582	88	27	and	and	CCONJ
admet-2582	88	28	metabolism	metabolism	NOUN
admet-2582	88	29	doi	doi	NOUN
admet-2582	88	30	:	:	PUNCT
admet-2582	88	31	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	88	32	5	5	NUM
admet-2582	88	33	16	16	NUM
admet-2582	88	34	mg	mg	NUM
admet-2582	88	35	/	/	SYM
admet-2582	88	36	kg	kg	PROPN
admet-2582	88	37	in	in	ADP
admet-2582	88	38	rats	rat	NOUN
admet-2582	88	39	,	,	PUNCT
admet-2582	88	40	the	the	DET
admet-2582	88	41	exposure	exposure	NOUN
admet-2582	88	42	levels	level	NOUN
admet-2582	88	43	of	of	ADP
admet-2582	88	44	ca	ca	NOUN
admet-2582	88	45	were	be	AUX
admet-2582	88	46	positively	positively	ADV
admet-2582	88	47	correlated	correlate	VERB
admet-2582	88	48	with	with	ADP
admet-2582	88	49	the	the	DET
admet-2582	88	50	dose	dose	NOUN
admet-2582	88	51	(	(	PUNCT
admet-2582	88	52	figure	figure	NOUN
admet-2582	88	53	2	2	NUM
admet-2582	88	54	and	and	CCONJ
admet-2582	88	55	table	table	NOUN
admet-2582	88	56	1	1	NUM
admet-2582	88	57	)	)	PUNCT
admet-2582	88	58	,	,	PUNCT
admet-2582	88	59	and	and	CCONJ
admet-2582	88	60	the	the	DET
admet-2582	88	61	half	half	ADJ
admet-2582	88	62	-	-	PUNCT
admet-2582	88	63	life	life	NOUN
admet-2582	88	64	(	(	PUNCT
admet-2582	88	65	t1/2	t1/2	VERB
admet-2582	88	66	time	time	NOUN
admet-2582	88	67	required	require	VERB
admet-2582	88	68	for	for	ADP
admet-2582	88	69	the	the	DET
admet-2582	88	70	concentration	concentration	NOUN
admet-2582	88	71	of	of	ADP
admet-2582	88	72	a	a	DET
admet-2582	88	73	drug	drug	NOUN
admet-2582	88	74	or	or	CCONJ
admet-2582	88	75	a	a	DET
admet-2582	88	76	substance	substance	NOUN
admet-2582	88	77	in	in	ADP
admet-2582	88	78	the	the	DET
admet-2582	88	79	body	body	NOUN
admet-2582	88	80	to	to	PART
admet-2582	88	81	decrease	decrease	VERB
admet-2582	88	82	by	by	ADP
admet-2582	88	83	half	half	NOUN
admet-2582	88	84	.	.	PUNCT
admet-2582	88	85	)	)	PUNCT
admet-2582	88	86	,	,	PUNCT
admet-2582	88	87	clearance	clearance	NOUN
admet-2582	88	88	(	(	PUNCT
admet-2582	88	89	cl	cl	NOUN
admet-2582	88	90	volume	volume	NOUN
admet-2582	88	91	of	of	ADP
admet-2582	88	92	blood	blood	NOUN
admet-2582	88	93	or	or	CCONJ
admet-2582	88	94	plasma	plasma	NOUN
admet-2582	88	95	that	that	PRON
admet-2582	88	96	is	be	AUX
admet-2582	88	97	cleared	clear	VERB
admet-2582	88	98	of	of	ADP
admet-2582	88	99	a	a	DET
admet-2582	88	100	drug	drug	NOUN
admet-2582	88	101	per	per	ADP
admet-2582	88	102	unit	unit	NOUN
admet-2582	88	103	time	time	NOUN
admet-2582	88	104	)	)	PUNCT
admet-2582	88	105	and	and	CCONJ
admet-2582	88	106	mean	mean	VERB
admet-2582	88	107	residence	residence	NOUN
admet-2582	88	108	time	time	NOUN
admet-2582	88	109	to	to	PART
admet-2582	88	110	infinity	infinity	NOUN
admet-2582	88	111	(	(	PUNCT
admet-2582	88	112	mrtinf	mrtinf	ADJ
admet-2582	88	113	average	average	ADJ
admet-2582	88	114	time	time	NOUN
admet-2582	88	115	that	that	PRON
admet-2582	88	116	a	a	DET
admet-2582	88	117	drug	drug	NOUN
admet-2582	88	118	molecule	molecule	NOUN
admet-2582	88	119	spends	spend	NOUN
admet-2582	88	120	in	in	ADP
admet-2582	88	121	the	the	DET
admet-2582	88	122	body	body	NOUN
admet-2582	88	123	from	from	ADP
admet-2582	88	124	the	the	DET
admet-2582	88	125	time	time	NOUN
admet-2582	88	126	of	of	ADP
admet-2582	88	127	administration	administration	NOUN
admet-2582	88	128	until	until	SCONJ
admet-2582	88	129	it	it	PRON
admet-2582	88	130	is	be	AUX
admet-2582	88	131	completely	completely	ADV
admet-2582	88	132	eliminated	eliminate	VERB
admet-2582	88	133	)	)	PUNCT
admet-2582	88	134	were	be	AUX
admet-2582	88	135	consistent	consistent	ADJ
admet-2582	88	136	,	,	PUNCT
admet-2582	88	137	showing	show	VERB
admet-2582	88	138	linear	linear	ADJ
admet-2582	88	139	dynamic	dynamic	ADJ
admet-2582	88	140	characteristics	characteristic	NOUN
admet-2582	88	141	.	.	PUNCT
admet-2582	89	1	t	t	NOUN
admet-2582	89	2	-	-	PUNCT
admet-2582	89	3	test	test	NOUN
admet-2582	89	4	results	result	NOUN
admet-2582	89	5	illustrated	illustrate	VERB
admet-2582	89	6	no	no	DET
admet-2582	89	7	significant	significant	ADJ
admet-2582	89	8	differences	difference	NOUN
admet-2582	89	9	in	in	ADP
admet-2582	89	10	t1/2	t1/2	NOUN
admet-2582	89	11	,	,	PUNCT
admet-2582	89	12	time	time	NOUN
admet-2582	89	13	to	to	ADP
admet-2582	89	14	maximum	maximum	ADJ
admet-2582	89	15	concentration	concentration	NOUN
admet-2582	89	16	(	(	PUNCT
admet-2582	89	17	tmax	tmax	DET
admet-2582	89	18	time	time	NOUN
admet-2582	89	19	it	it	PRON
admet-2582	89	20	takes	take	VERB
admet-2582	89	21	for	for	SCONJ
admet-2582	89	22	a	a	DET
admet-2582	89	23	drug	drug	NOUN
admet-2582	89	24	to	to	PART
admet-2582	89	25	reach	reach	VERB
admet-2582	89	26	its	its	PRON
admet-2582	89	27	maximum	maximum	ADJ
admet-2582	89	28	concentration	concentration	NOUN
admet-2582	89	29	in	in	ADP
admet-2582	89	30	the	the	DET
admet-2582	89	31	bloodstream	bloodstream	NOUN
admet-2582	89	32	or	or	CCONJ
admet-2582	89	33	a	a	DET
admet-2582	89	34	specific	specific	ADJ
admet-2582	89	35	tissue	tissue	NOUN
admet-2582	89	36	after	after	ADP
admet-2582	89	37	administration	administration	NOUN
admet-2582	89	38	)	)	PUNCT
admet-2582	89	39	,	,	PUNCT
admet-2582	89	40	cl	cl	NOUN
admet-2582	89	41	and	and	CCONJ
admet-2582	89	42	mrtinf	mrtinf	NOUN
admet-2582	89	43	of	of	ADP
admet-2582	89	44	ca	ca	NOUN
admet-2582	89	45	between	between	ADP
admet-2582	89	46	the	the	DET
admet-2582	89	47	different	different	ADJ
admet-2582	89	48	dose	dose	NOUN
admet-2582	89	49	groups	group	NOUN
admet-2582	89	50	(	(	PUNCT
admet-2582	89	51	p>0.05	p>0.05	PROPN
admet-2582	89	52	)	)	PUNCT
admet-2582	89	53	,	,	PUNCT
admet-2582	89	54	showing	show	VERB
admet-2582	89	55	linear	linear	NOUN
admet-2582	89	56	dynamics	dynamic	NOUN
admet-2582	89	57	characteristics	characteristic	NOUN
admet-2582	89	58	.	.	PUNCT
admet-2582	90	1	at	at	ADP
admet-2582	90	2	the	the	DET
admet-2582	90	3	same	same	ADJ
admet-2582	90	4	administration	administration	NOUN
admet-2582	90	5	dose	dose	PROPN
admet-2582	90	6	,	,	PUNCT
admet-2582	90	7	the	the	DET
admet-2582	90	8	auc	auc	NOUN
admet-2582	90	9	of	of	ADP
admet-2582	90	10	ca	ca	NOUN
admet-2582	90	11	was	be	AUX
admet-2582	90	12	significantly	significantly	ADV
admet-2582	90	13	lower	low	ADJ
admet-2582	90	14	than	than	ADP
admet-2582	90	15	that	that	PRON
admet-2582	90	16	of	of	ADP
admet-2582	90	17	ta	ta	PROPN
admet-2582	90	18	(	(	PUNCT
admet-2582	90	19	p<0.05	p<0.05	PROPN
admet-2582	90	20	)	)	PUNCT
admet-2582	90	21	,	,	PUNCT
admet-2582	90	22	and	and	CCONJ
admet-2582	90	23	the	the	DET
admet-2582	90	24	system	system	NOUN
admet-2582	90	25	clearance	clearance	NOUN
admet-2582	90	26	rate	rate	NOUN
admet-2582	90	27	of	of	ADP
admet-2582	90	28	cl	cl	NOUN
admet-2582	90	29	was	be	AUX
admet-2582	90	30	significantly	significantly	ADV
admet-2582	90	31	higher	high	ADJ
admet-2582	90	32	than	than	ADP
admet-2582	90	33	that	that	PRON
admet-2582	90	34	of	of	ADP
admet-2582	90	35	ta	ta	PROPN
admet-2582	90	36	(	(	PUNCT
admet-2582	90	37	p<0.05	p<0.05	PROPN
admet-2582	90	38	)	)	PUNCT
admet-2582	90	39	,	,	PUNCT
admet-2582	90	40	indicating	indicate	VERB
admet-2582	90	41	that	that	SCONJ
admet-2582	90	42	the	the	DET
admet-2582	90	43	clearance	clearance	NOUN
admet-2582	90	44	of	of	ADP
admet-2582	90	45	ca	ca	NOUN
admet-2582	90	46	in	in	ADP
admet-2582	90	47	vivo	vivo	NOUN
admet-2582	90	48	was	be	AUX
admet-2582	90	49	greater	great	ADJ
admet-2582	90	50	than	than	ADP
admet-2582	90	51	that	that	PRON
admet-2582	90	52	of	of	ADP
admet-2582	90	53	tab	tab	NOUN
admet-2582	90	54	(	(	PUNCT
admet-2582	90	55	table	table	NOUN
admet-2582	90	56	1	1	NUM
admet-2582	90	57	)	)	PUNCT
admet-2582	90	58	.	.	PUNCT
admet-2582	91	1	as	as	ADP
admet-2582	91	2	a	a	DET
admet-2582	91	3	result	result	NOUN
admet-2582	91	4	,	,	PUNCT
admet-2582	91	5	they	they	PRON
admet-2582	91	6	exhibited	exhibit	VERB
admet-2582	91	7	approximately	approximately	ADV
admet-2582	91	8	the	the	DET
admet-2582	91	9	same	same	ADJ
admet-2582	91	10	half	half	ADJ
admet-2582	91	11	-	-	PUNCT
admet-2582	91	12	lives	life	NOUN
admet-2582	91	13	,	,	PUNCT
admet-2582	91	14	while	while	SCONJ
admet-2582	91	15	the	the	DET
admet-2582	91	16	generally	generally	ADV
admet-2582	91	17	shorter	short	ADJ
admet-2582	91	18	clearance	clearance	NOUN
admet-2582	91	19	was	be	AUX
admet-2582	91	20	observed	observe	VERB
admet-2582	91	21	for	for	ADP
admet-2582	91	22	tab	tab	NOUN
admet-2582	91	23	(	(	PUNCT
admet-2582	91	24	table	table	NOUN
admet-2582	91	25	1	1	NUM
admet-2582	91	26	)	)	PUNCT
admet-2582	91	27	.	.	PUNCT
admet-2582	92	1	in	in	ADP
admet-2582	92	2	addition	addition	NOUN
admet-2582	92	3	,	,	PUNCT
admet-2582	92	4	the	the	DET
admet-2582	92	5	corresponding	corresponding	ADJ
admet-2582	92	6	systemic	systemic	ADJ
admet-2582	92	7	exposures	exposure	NOUN
admet-2582	92	8	showed	show	VERB
admet-2582	92	9	a	a	DET
admet-2582	92	10	positive	positive	ADJ
admet-2582	92	11	correlation	correlation	NOUN
admet-2582	92	12	with	with	ADP
admet-2582	92	13	the	the	DET
admet-2582	92	14	dose	dose	NOUN
admet-2582	92	15	escalation	escalation	NOUN
admet-2582	92	16	from	from	ADP
admet-2582	92	17	4	4	NUM
admet-2582	92	18	to	to	PART
admet-2582	92	19	16	16	NUM
admet-2582	92	20	mg	mg	PROPN
admet-2582	92	21	/	/	SYM
admet-2582	92	22	kg	kg	PROPN
admet-2582	92	23	(	(	PUNCT
admet-2582	92	24	table	table	NOUN
admet-2582	92	25	1	1	NUM
admet-2582	92	26	)	)	PUNCT
admet-2582	92	27	.	.	PUNCT
admet-2582	93	1	time	time	NOUN
admet-2582	93	2	,	,	PUNCT
admet-2582	93	3	h	h	NOUN
admet-2582	93	4	figure	figure	NOUN
admet-2582	93	5	2	2	NUM
admet-2582	93	6	.	.	X
admet-2582	93	7	serum	serum	NOUN
admet-2582	93	8	concentration−time	concentration−time	NOUN
admet-2582	93	9	profiles	profile	NOUN
admet-2582	93	10	of	of	ADP
admet-2582	93	11	rc48	rc48	PROPN
admet-2582	93	12	-	-	PUNCT
admet-2582	93	13	adc	adc	PROPN
admet-2582	93	14	,	,	PUNCT
admet-2582	93	15	total	total	PROPN
admet-2582	93	16	ab	ab	PROPN
admet-2582	93	17	,	,	PUNCT
admet-2582	93	18	and	and	CCONJ
admet-2582	93	19	mmae	mmae	NOUN
admet-2582	93	20	in	in	ADP
admet-2582	93	21	rats	rat	NOUN
admet-2582	93	22	after	after	SCONJ
admet-2582	93	23	iv	iv	NUM
admet-2582	93	24	administration	administration	NOUN
admet-2582	93	25	of	of	ADP
admet-2582	93	26	rc48	rc48	PROPN
admet-2582	93	27	-	-	PUNCT
admet-2582	93	28	adc(4	adc(4	PROPN
admet-2582	93	29	to	to	ADP
admet-2582	93	30	16	16	NUM
admet-2582	93	31	mg	mg	PROPN
admet-2582	93	32	/	/	SYM
admet-2582	93	33	kg	kg	NOUN
admet-2582	93	34	)	)	PUNCT
admet-2582	93	35	or	or	CCONJ
admet-2582	93	36	rc48	rc48	PROPN
admet-2582	93	37	-	-	PUNCT
admet-2582	93	38	adc	adc	PROPN
admet-2582	93	39	ab	ab	PROPN
admet-2582	93	40	combination	combination	NOUN
admet-2582	93	41	with	with	ADP
admet-2582	93	42	mmae	mmae	NOUN
admet-2582	93	43	(	(	PUNCT
admet-2582	93	44	8	8	NUM
admet-2582	93	45	+	+	NOUN
admet-2582	93	46	0.16	0.16	NUM
admet-2582	93	47	mg	mg	PROPN
admet-2582	93	48	/	/	SYM
admet-2582	93	49	kg	kg	NOUN
admet-2582	93	50	)	)	PUNCT
admet-2582	93	51	(	(	PUNCT
admet-2582	93	52	mean	mean	PROPN
admet-2582	93	53	±	±	NUM
admet-2582	93	54	sd	sd	NOUN
admet-2582	93	55	,	,	PUNCT
admet-2582	93	56	n	n	NOUN
admet-2582	93	57	=	=	NUM
admet-2582	93	58	6	6	NUM
admet-2582	93	59	per	per	ADP
admet-2582	93	60	time	time	NOUN
admet-2582	93	61	point	point	NOUN
admet-2582	93	62	)	)	PUNCT
admet-2582	94	1	fm	fm	PROPN
admet-2582	94	2	showed	show	VERB
admet-2582	94	3	linear	linear	ADJ
admet-2582	94	4	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	94	5	in	in	ADP
admet-2582	94	6	the	the	DET
admet-2582	94	7	dose	dose	ADJ
admet-2582	94	8	range	range	NOUN
admet-2582	94	9	of	of	ADP
admet-2582	94	10	4	4	NUM
admet-2582	94	11	-	-	SYM
admet-2582	94	12	8	8	NUM
admet-2582	94	13	mg	mg	NUM
admet-2582	94	14	/	/	SYM
admet-2582	94	15	kg	kg	NOUN
admet-2582	94	16	and	and	CCONJ
admet-2582	94	17	nonlinear	nonlinear	ADJ
admet-2582	94	18	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	94	19	when	when	SCONJ
admet-2582	94	20	the	the	DET
admet-2582	94	21	dose	dose	NOUN
admet-2582	94	22	was	be	AUX
admet-2582	94	23	increased	increase	VERB
admet-2582	94	24	to	to	ADP
admet-2582	94	25	16	16	NUM
admet-2582	94	26	mg	mg	PROPN
admet-2582	94	27	/	/	SYM
admet-2582	94	28	kg	kg	PROPN
admet-2582	94	29	(	(	PUNCT
admet-2582	94	30	figure	figure	NOUN
admet-2582	94	31	2	2	NUM
admet-2582	94	32	and	and	CCONJ
admet-2582	94	33	table	table	NOUN
admet-2582	94	34	1	1	NUM
admet-2582	94	35	)	)	PUNCT
admet-2582	94	36	.	.	PUNCT
admet-2582	95	1	compared	compare	VERB
admet-2582	95	2	with	with	ADP
admet-2582	95	3	the	the	DET
admet-2582	95	4	same	same	ADJ
admet-2582	95	5	dose	dose	NOUN
admet-2582	95	6	of	of	ADP
admet-2582	95	7	the	the	DET
admet-2582	95	8	rc48	rc48	PROPN
admet-2582	95	9	-	-	PUNCT
admet-2582	95	10	adc	adc	PROPN
admet-2582	95	11	group	group	NOUN
admet-2582	95	12	(	(	PUNCT
admet-2582	95	13	8	8	NUM
admet-2582	95	14	mg	mg	NUM
admet-2582	95	15	/	/	SYM
admet-2582	95	16	kg	kg	PROPN
admet-2582	95	17	)	)	PUNCT
admet-2582	95	18	,	,	PUNCT
admet-2582	95	19	the	the	DET
admet-2582	95	20	tab	tab	NOUN
admet-2582	95	21	concentration	concentration	NOUN
admet-2582	95	22	of	of	ADP
admet-2582	95	23	the	the	DET
admet-2582	95	24	combined	combine	VERB
admet-2582	95	25	group	group	NOUN
admet-2582	95	26	was	be	AUX
admet-2582	95	27	similar	similar	ADJ
admet-2582	95	28	to	to	ADP
admet-2582	95	29	that	that	PRON
admet-2582	95	30	of	of	ADP
admet-2582	95	31	the	the	DET
admet-2582	95	32	rc48	rc48	PROPN
admet-2582	95	33	-	-	PUNCT
admet-2582	95	34	adc	adc	PROPN
admet-2582	95	35	group	group	NOUN
admet-2582	95	36	(	(	PUNCT
admet-2582	95	37	figure	figure	NOUN
admet-2582	95	38	2	2	NUM
admet-2582	95	39	and	and	CCONJ
admet-2582	95	40	table	table	NOUN
admet-2582	95	41	1	1	NUM
admet-2582	95	42	)	)	PUNCT
admet-2582	95	43	.	.	PUNCT
admet-2582	96	1	meanwhile	meanwhile	ADV
admet-2582	96	2	,	,	PUNCT
admet-2582	96	3	the	the	DET
admet-2582	96	4	plasma	plasma	NOUN
admet-2582	96	5	peak	peak	NOUN
admet-2582	96	6	concentration	concentration	NOUN
admet-2582	96	7	and	and	CCONJ
admet-2582	96	8	exposure	exposure	NOUN
admet-2582	96	9	levels	level	NOUN
admet-2582	96	10	of	of	ADP
admet-2582	96	11	fm	fm	PROPN
admet-2582	96	12	in	in	ADP
admet-2582	96	13	the	the	DET
admet-2582	96	14	rc48adc	rc48adc	PROPN
admet-2582	96	15	group	group	NOUN
admet-2582	96	16	(	(	PUNCT
admet-2582	96	17	8	8	NUM
admet-2582	96	18	mg	mg	NUM
admet-2582	96	19	/	/	SYM
admet-2582	96	20	kg	kg	PROPN
admet-2582	96	21	)	)	PUNCT
admet-2582	96	22	were	be	AUX
admet-2582	96	23	approximately	approximately	ADV
admet-2582	96	24	0.09	0.09	NUM
admet-2582	96	25	and	and	CCONJ
admet-2582	96	26	5.56	5.56	NUM
admet-2582	96	27	%	%	NOUN
admet-2582	96	28	of	of	ADP
admet-2582	96	29	the	the	DET
admet-2582	96	30	equivalent	equivalent	NOUN
admet-2582	96	31	directly	directly	ADV
admet-2582	96	32	injected	inject	VERB
admet-2582	96	33	combined	combined	ADJ
admet-2582	96	34	group	group	NOUN
admet-2582	96	35	,	,	PUNCT
admet-2582	96	36	respectively	respectively	ADV
admet-2582	96	37	(	(	PUNCT
admet-2582	96	38	table	table	NOUN
admet-2582	96	39	1	1	NUM
admet-2582	96	40	)	)	PUNCT
admet-2582	96	41	.	.	PUNCT
admet-2582	97	1	the	the	DET
admet-2582	97	2	concentration	concentration	NOUN
admet-2582	97	3	-	-	PUNCT
admet-2582	97	4	time	time	NOUN
admet-2582	97	5	curve	curve	NOUN
admet-2582	97	6	of	of	ADP
admet-2582	97	7	fm	fm	PROPN
admet-2582	97	8	in	in	ADP
admet-2582	97	9	the	the	DET
admet-2582	97	10	rc48	rc48	PROPN
admet-2582	97	11	-	-	PUNCT
admet-2582	97	12	adc	adc	PROPN
admet-2582	97	13	group	group	NOUN
admet-2582	97	14	of	of	ADP
admet-2582	97	15	rats	rat	NOUN
admet-2582	97	16	showed	show	VERB
admet-2582	97	17	a	a	DET
admet-2582	97	18	bimodal	bimodal	NOUN
admet-2582	97	19	phenomenon	phenomenon	NOUN
admet-2582	97	20	(	(	PUNCT
admet-2582	97	21	figure	figure	NOUN
admet-2582	97	22	2	2	NUM
admet-2582	97	23	)	)	PUNCT
admet-2582	97	24	.	.	PUNCT
admet-2582	98	1	these	these	PRON
admet-2582	98	2	in	in	ADP
admet-2582	98	3	vivo	vivo	ADJ
admet-2582	98	4	results	result	NOUN
admet-2582	98	5	were	be	AUX
admet-2582	98	6	strongly	strongly	ADV
admet-2582	98	7	supported	support	VERB
admet-2582	98	8	by	by	ADP
admet-2582	98	9	our	our	PRON
admet-2582	98	10	previous	previous	ADJ
admet-2582	98	11	finding	finding	NOUN
admet-2582	98	12	that	that	SCONJ
admet-2582	98	13	only	only	ADV
admet-2582	98	14	a	a	DET
admet-2582	98	15	small	small	ADJ
admet-2582	98	16	percentage	percentage	NOUN
admet-2582	98	17	of	of	ADP
admet-2582	98	18	mmae	mmae	NOUN
admet-2582	98	19	is	be	AUX
admet-2582	98	20	released	release	VERB
admet-2582	98	21	after	after	ADP
admet-2582	98	22	the	the	DET
admet-2582	98	23	in	in	X
admet-2582	98	24	vitro	vitro	X
admet-2582	98	25	incubation	incubation	NOUN
admet-2582	98	26	of	of	ADP
admet-2582	98	27	rc48	rc48	PROPN
admet-2582	98	28	-	-	PUNCT
admet-2582	98	29	adc	adc	PROPN
admet-2582	98	30	with	with	ADP
admet-2582	98	31	the	the	DET
admet-2582	98	32	serum	serum	NOUN
admet-2582	98	33	of	of	ADP
admet-2582	98	34	rats	rat	NOUN
admet-2582	98	35	.	.	PUNCT
admet-2582	99	1	according	accord	VERB
admet-2582	99	2	to	to	ADP
admet-2582	99	3	these	these	PRON
admet-2582	99	4	in	in	ADP
admet-2582	99	5	vitro	vitro	X
admet-2582	99	6	and	and	CCONJ
admet-2582	99	7	in	in	ADP
admet-2582	99	8	vivo	vivo	NOUN
admet-2582	99	9	results	result	NOUN
admet-2582	99	10	,	,	PUNCT
admet-2582	99	11	the	the	DET
admet-2582	99	12	linker	linker	NOUN
admet-2582	99	13	of	of	ADP
admet-2582	99	14	rc48	rc48	PROPN
admet-2582	99	15	-	-	PUNCT
admet-2582	99	16	adc	adc	PROPN
admet-2582	99	17	is	be	AUX
admet-2582	99	18	expected	expect	VERB
admet-2582	99	19	to	to	PART
admet-2582	99	20	be	be	AUX
admet-2582	99	21	stable	stable	ADJ
admet-2582	99	22	in	in	ADP
admet-2582	99	23	the	the	DET
admet-2582	99	24	human	human	ADJ
admet-2582	99	25	systemic	systemic	ADJ
admet-2582	99	26	circulation	circulation	NOUN
admet-2582	99	27	.	.	PUNCT
admet-2582	100	1	compared	compare	VERB
admet-2582	100	2	with	with	ADP
admet-2582	100	3	the	the	DET
admet-2582	100	4	same	same	ADJ
admet-2582	100	5	dose	dose	NOUN
admet-2582	100	6	of	of	ADP
admet-2582	100	7	the	the	DET
admet-2582	100	8	rc48	rc48	PROPN
admet-2582	100	9	-	-	PUNCT
admet-2582	100	10	adc	adc	PROPN
admet-2582	100	11	group	group	NOUN
admet-2582	100	12	,	,	PUNCT
admet-2582	100	13	the	the	DET
admet-2582	100	14	plasma	plasma	NOUN
admet-2582	100	15	peak	peak	NOUN
admet-2582	100	16	concentration	concentration	NOUN
admet-2582	100	17	and	and	CCONJ
admet-2582	100	18	exposure	exposure	NOUN
admet-2582	100	19	levels	level	NOUN
admet-2582	100	20	of	of	ADP
admet-2582	100	21	fm	fm	PROPN
admet-2582	100	22	in	in	ADP
admet-2582	100	23	the	the	DET
admet-2582	100	24	equal	equal	ADJ
admet-2582	100	25	-	-	PUNCT
admet-2582	100	26	quality	quality	NOUN
admet-2582	100	27	combined	combine	VERB
admet-2582	100	28	group	group	NOUN
admet-2582	100	29	increased	increase	VERB
admet-2582	100	30	tremendously	tremendously	ADV
admet-2582	100	31	,	,	PUNCT
admet-2582	100	32	which	which	PRON
admet-2582	100	33	indicates	indicate	VERB
admet-2582	100	34	that	that	SCONJ
admet-2582	100	35	the	the	DET
admet-2582	100	36	molecular	molecular	ADJ
admet-2582	100	37	structure	structure	NOUN
admet-2582	100	38	of	of	ADP
admet-2582	100	39	rc48	rc48	PROPN
admet-2582	100	40	-	-	PUNCT
admet-2582	100	41	adc	adc	PROPN
admet-2582	100	42	effectively	effectively	ADV
admet-2582	100	43	reduces	reduce	VERB
admet-2582	100	44	the	the	DET
admet-2582	100	45	exposure	exposure	NOUN
admet-2582	100	46	of	of	ADP
admet-2582	100	47	small	small	ADJ
admet-2582	100	48	molecules	molecule	NOUN
admet-2582	100	49	in	in	ADP
admet-2582	100	50	the	the	DET
admet-2582	100	51	body	body	NOUN
admet-2582	100	52	.	.	PUNCT
admet-2582	101	1	this	this	DET
admet-2582	101	2	part	part	NOUN
admet-2582	101	3	of	of	ADP
admet-2582	101	4	the	the	DET
admet-2582	101	5	experiment	experiment	NOUN
admet-2582	101	6	not	not	PART
admet-2582	101	7	only	only	ADV
admet-2582	101	8	elucidates	elucidate	VERB
admet-2582	101	9	the	the	DET
admet-2582	101	10	pharmacokinetic	pharmacokinetic	ADJ
admet-2582	101	11	characteristics	characteristic	NOUN
admet-2582	101	12	of	of	ADP
admet-2582	101	13	rc48	rc48	PROPN
admet-2582	101	14	-	-	PUNCT
admet-2582	101	15	adc	adc	PROPN
admet-2582	101	16	in	in	ADP
admet-2582	101	17	rats	rat	NOUN
admet-2582	101	18	but	but	CCONJ
admet-2582	101	19	also	also	ADV
admet-2582	101	20	provides	provide	VERB
admet-2582	101	21	data	datum	NOUN
admet-2582	101	22	support	support	NOUN
admet-2582	101	23	for	for	ADP
admet-2582	101	24	the	the	DET
admet-2582	101	25	prediction	prediction	NOUN
admet-2582	101	26	of	of	ADP
admet-2582	101	27	human	human	ADJ
admet-2582	101	28	pk	pk	NOUN
admet-2582	101	29	by	by	ADP
admet-2582	101	30	the	the	DET
admet-2582	101	31	allometric	allometric	ADJ
admet-2582	101	32	scaling	scaling	NOUN
admet-2582	101	33	method	method	NOUN
admet-2582	101	34	[	[	X
admet-2582	101	35	13	13	NUM
admet-2582	101	36	]	]	PUNCT
admet-2582	101	37	.	.	PUNCT
admet-2582	102	1	c	c	NOUN
admet-2582	102	2	/	/	SYM
admet-2582	102	3			NOUN
admet-2582	102	4	g	g	PROPN
admet-2582	102	5	m	m	PROPN
admet-2582	102	6	l-1	l-1	PROPN
admet-2582	102	7	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	PROPN
admet-2582	102	8	m.	m.	NOUN
admet-2582	102	9	das	das	PROPN
admet-2582	102	10	et	et	PROPN
admet-2582	102	11	al	al	PROPN
admet-2582	102	12	.	.	PROPN
admet-2582	102	13	admet	admet	PROPN
admet-2582	102	14	&	&	CCONJ
admet-2582	102	15	dmpk	dmpk	PROPN
admet-2582	102	16	13(2	13(2	PROPN
admet-2582	102	17	)	)	PUNCT
admet-2582	102	18	(	(	PUNCT
admet-2582	102	19	2025	2025	NUM
admet-2582	102	20	)	)	PUNCT
admet-2582	102	21	2582	2582	NUM
admet-2582	102	22	6	6	NUM
admet-2582	102	23	table	table	NOUN
admet-2582	102	24	1	1	NUM
admet-2582	102	25	.	.	X
admet-2582	102	26	pk	pk	NOUN
admet-2582	102	27	parameters	parameter	NOUN
admet-2582	102	28	of	of	ADP
admet-2582	102	29	rc48	rc48	PROPN
admet-2582	102	30	-	-	PUNCT
admet-2582	102	31	adc	adc	PROPN
admet-2582	102	32	,	,	PUNCT
admet-2582	102	33	total	total	ADJ
admet-2582	102	34	ab	ab	PROPN
admet-2582	102	35	and	and	CCONJ
admet-2582	102	36	mmae	mmae	PROPN
admet-2582	102	37	following	follow	VERB
admet-2582	102	38	iv	iv	NUM
admet-2582	102	39	administration	administration	NOUN
admet-2582	102	40	of	of	ADP
admet-2582	102	41	rc48	rc48	PROPN
admet-2582	102	42	-	-	PUNCT
admet-2582	102	43	adc	adc	PROPN
admet-2582	102	44	(	(	PUNCT
admet-2582	102	45	4	4	NUM
admet-2582	102	46	to16	to16	PROPN
admet-2582	102	47	mg	mg	PROPN
admet-2582	102	48	/	/	SYM
admet-2582	102	49	kg	kg	PROPN
admet-2582	102	50	)	)	PUNCT
admet-2582	102	51	or	or	CCONJ
admet-2582	102	52	rc48	rc48	PROPN
admet-2582	102	53	-	-	PUNCT
admet-2582	102	54	adc	adc	PROPN
admet-2582	102	55	ab	ab	PROPN
admet-2582	102	56	combination	combination	NOUN
admet-2582	102	57	with	with	ADP
admet-2582	102	58	mmae	mmae	NOUN
admet-2582	102	59	(	(	PUNCT
admet-2582	102	60	8	8	NUM
admet-2582	102	61	+	+	NUM
admet-2582	102	62	0.16	0.16	NUM
admet-2582	102	63	mg	mg	PROPN
admet-2582	102	64	/	/	SYM
admet-2582	102	65	kg	kg	NOUN
admet-2582	102	66	)	)	PUNCT
admet-2582	102	67	to	to	ADP
admet-2582	102	68	rats	rat	NOUN
admet-2582	102	69	.	.	PUNCT
admet-2582	103	1	parameter	parameter	PROPN
admet-2582	103	2	t1/2	t1/2	NOUN
admet-2582	103	3	/	/	SYM
admet-2582	103	4	h	h	NOUN
admet-2582	103	5	tmax	tmax	ADV
admet-2582	103	6	/	/	SYM
admet-2582	103	7	h	h	NOUN
admet-2582	103	8	cmax	cmax	VERB
admet-2582	103	9	a	a	DET
admet-2582	103	10	/	/	SYM
admet-2582	103	11	µg	µg	ADV
admet-2582	103	12	ml-1	ml-1	PRON
admet-2582	103	13	auc(0	auc(0	NOUN
admet-2582	103	14	-	-	PUNCT
admet-2582	103	15	t	t	PROPN
admet-2582	103	16	)	)	PUNCT
admet-2582	103	17	b	b	NOUN
admet-2582	103	18	,	,	PUNCT
admet-2582	103	19	h	h	NOUN
admet-2582	103	20	µg	µg	VERB
admet-2582	103	21	ml-1	ml-1	DET
admet-2582	103	22	auc(0	auc(0	ADV
admet-2582	103	23	-	-	PUNCT
admet-2582	103	24	inf	inf	ADJ
admet-2582	103	25	)	)	PUNCT
admet-2582	103	26	b	b	NOUN
admet-2582	103	27	,	,	PUNCT
admet-2582	103	28	h	h	NOUN
admet-2582	103	29	µg	µg	VERB
admet-2582	103	30	ml-1	ml-1	ADV
admet-2582	103	31	auc(t	auc(t	PROPN
admet-2582	103	32	-	-	PUNCT
admet-2582	103	33	inf	inf	NOUN
admet-2582	103	34	)	)	PUNCT
admet-2582	103	35	,	,	PUNCT
admet-2582	103	36	%	%	INTJ
admet-2582	103	37	vd	vd	NOUN
admet-2582	103	38	/	/	SYM
admet-2582	103	39	ml	ml	INTJ
admet-2582	103	40	kg-1	kg-1	PRON
admet-2582	103	41	cl	cl	NOUN
admet-2582	103	42	,	,	PUNCT
admet-2582	103	43	(	(	PUNCT
admet-2582	103	44	ml	ml	PROPN
admet-2582	103	45	h-1	h-1	NUM
admet-2582	103	46	)	)	PUNCT
admet-2582	103	47	kg-1	kg-1	X
admet-2582	103	48	mrtinf	mrtinf	PROPN
admet-2582	103	49	,	,	PUNCT
admet-2582	103	50	h	h	PROPN
admet-2582	103	51	rc48	rc48	PROPN
admet-2582	103	52	-	-	PUNCT
admet-2582	103	53	adc	adc	PROPN
admet-2582	103	54	4	4	NUM
admet-2582	103	55	mg	mg	PROPN
admet-2582	103	56	kg-1	kg-1	NOUN
admet-2582	104	1	total	total	PROPN
admet-2582	105	1	ab	ab	PROPN
admet-2582	106	1	206.94±	206.94±	NUM
admet-2582	106	2	83.34	83.34	NUM
admet-2582	106	3	0.02±0.00	0.02±0.00	NOUN
admet-2582	106	4	63.18±8.23	63.18±8.23	NUM
admet-2582	107	1	1974.28±	1974.28±	NUM
admet-2582	108	1	463.83	463.83	NUM
admet-2582	108	2	2229.21±	2229.21±	NUM
admet-2582	108	3	613.9	613.9	NUM
admet-2582	108	4	10.64±	10.64±	NUM
admet-2582	108	5	5.62	5.62	NUM
admet-2582	108	6	534.62±	534.62±	NUM
admet-2582	108	7	165.47	165.47	NUM
admet-2582	108	8	1.90±	1.90±	NUM
admet-2582	108	9	0.47	0.47	NUM
admet-2582	108	10	240.13±	240.13±	NUM
admet-2582	108	11	79.75	79.75	NUM
admet-2582	108	12	rc48	rc48	PROPN
admet-2582	108	13	-	-	PUNCT
admet-2582	108	14	adc	adc	PROPN
admet-2582	108	15	180.28±	180.28±	NUM
admet-2582	108	16	82.44	82.44	NUM
admet-2582	108	17	0.02±0.00	0.02±0.00	NUM
admet-2582	108	18	59.07±12.22	59.07±12.22	NUM
admet-2582	108	19	1096.53±	1096.53±	NUM
admet-2582	108	20	115.05	115.05	NUM
admet-2582	108	21	1150.01±	1150.01±	NUM
admet-2582	108	22	134.65	134.65	NUM
admet-2582	108	23	4.51±	4.51±	NUM
admet-2582	109	1	2.91	2.91	NUM
admet-2582	109	2	894.72±	894.72±	NUM
admet-2582	109	3	347.88	347.88	NUM
admet-2582	109	4	3.52±	3.52±	NUM
admet-2582	109	5	0.41	0.41	NUM
admet-2582	109	6	133.88±	133.88±	NUM
admet-2582	109	7	45.07	45.07	NUM
admet-2582	109	8	mmae	mmae	NOUN
admet-2582	109	9	12.34±11.66	12.34±11.66	NUM
admet-2582	109	10	0.137±0.029	0.137±0.029	NOUN
admet-2582	109	11	4.15±1.05	4.15±1.05	PROPN
admet-2582	109	12	rc48	rc48	PROPN
admet-2582	109	13	-	-	PUNCT
admet-2582	109	14	adc	adc	PROPN
admet-2582	109	15	8	8	NUM
admet-2582	109	16	mg	mg	PROPN
admet-2582	109	17	kg-1	kg-1	NOUN
admet-2582	109	18	total	total	PROPN
admet-2582	109	19	ab	ab	PROPN
admet-2582	110	1	184.21±	184.21±	NUM
admet-2582	110	2	48.56	48.56	NUM
admet-2582	110	3	0.04±0.06	0.04±0.06	NUM
admet-2582	110	4	120.88±30.79	120.88±30.79	NUM
admet-2582	110	5	4561.78±	4561.78±	NUM
admet-2582	110	6	375.70	375.70	NUM
admet-2582	110	7	4891.05±	4891.05±	NUM
admet-2582	110	8	410.53	410.53	NUM
admet-2582	110	9	6.70±	6.70±	NOUN
admet-2582	110	10	1.86	1.86	NUM
admet-2582	110	11	434.91±	434.91±	NUM
admet-2582	110	12	119.47	119.47	NUM
admet-2582	110	13	1.65±	1.65±	NUM
admet-2582	110	14	0.14	0.14	NUM
admet-2582	110	15	208.51±	208.51±	PROPN
admet-2582	110	16	44.18	44.18	NUM
admet-2582	110	17	rc48	rc48	PROPN
admet-2582	110	18	-	-	PUNCT
admet-2582	110	19	adc	adc	PROPN
admet-2582	110	20	174.08±	174.08±	NUM
admet-2582	110	21	52.23	52.23	NUM
admet-2582	110	22	0.04±0.06	0.04±0.06	NOUN
admet-2582	110	23	96.67±19.42	96.67±19.42	NUM
admet-2582	110	24	2541.41±	2541.41±	NUM
admet-2582	110	25	195.97	195.97	NUM
admet-2582	110	26	2634.57±	2634.57±	NUM
admet-2582	110	27	208.01	208.01	NUM
admet-2582	110	28	3.52±	3.52±	NUM
admet-2582	110	29	1.47	1.47	NUM
admet-2582	110	30	768.59±	768.59±	NUM
admet-2582	110	31	249.79	249.79	NUM
admet-2582	110	32	3.05±	3.05±	NUM
admet-2582	110	33	0.25	0.25	NUM
admet-2582	110	34	127.32±	127.32±	NUM
admet-2582	110	35	26.48	26.48	NUM
admet-2582	110	36	mmae	mmae	NOUN
admet-2582	110	37	17.34±14.66	17.34±14.66	NUM
admet-2582	110	38	0.22±0.039	0.22±0.039	PROPN
admet-2582	110	39	8.87±1.15	8.87±1.15	PROPN
admet-2582	110	40	rc48	rc48	PROPN
admet-2582	110	41	-	-	PUNCT
admet-2582	110	42	adc	adc	PROPN
admet-2582	110	43	16	16	NUM
admet-2582	110	44	mg	mg	PROPN
admet-2582	110	45	kg-1	kg-1	NOUN
admet-2582	110	46	total	total	PROPN
admet-2582	110	47	ab	ab	PROPN
admet-2582	111	1	156.86±	156.86±	NUM
admet-2582	111	2	114.43	114.43	NUM
admet-2582	111	3	0.10±0.20	0.10±0.20	NOUN
admet-2582	111	4	214.4±19.86	214.4±19.86	NUM
admet-2582	111	5	6793.91±	6793.91±	NUM
admet-2582	111	6	2389.51	2389.51	NUM
admet-2582	111	7	7547.62±	7547.62±	NOUN
admet-2582	111	8	2840.88	2840.88	NUM
admet-2582	111	9	9.07±	9.07±	NOUN
admet-2582	111	10	6.62	6.62	NUM
admet-2582	111	11	443.65±	443.65±	NUM
admet-2582	111	12	248.72	248.72	NUM
admet-2582	111	13	2.42±	2.42±	NOUN
admet-2582	111	14	1.00	1.00	NUM
admet-2582	111	15	220.43±	220.43±	NUM
admet-2582	111	16	107.77	107.77	NUM
admet-2582	111	17	rc48	rc48	PROPN
admet-2582	111	18	-	-	PUNCT
admet-2582	111	19	adc	adc	PROPN
admet-2582	112	1	117.17±	117.17±	NUM
admet-2582	112	2	73.81	73.81	NUM
admet-2582	112	3	0.02±0.00	0.02±0.00	NUM
admet-2582	112	4	344.5±395.5	344.5±395.5	NUM
admet-2582	112	5	4440.9±	4440.9±	NUM
admet-2582	112	6	974.01	974.01	NUM
admet-2582	112	7	4557.54±	4557.54±	NOUN
admet-2582	112	8	1061.94	1061.94	NUM
admet-2582	112	9	2.26±	2.26±	NUM
admet-2582	112	10	2.27	2.27	NUM
admet-2582	112	11	566.5±	566.5±	NUM
admet-2582	112	12	308.65	308.65	NUM
admet-2582	112	13	3.69±	3.69±	NUM
admet-2582	112	14	0.94	0.94	NUM
admet-2582	112	15	105.79±	105.79±	NUM
admet-2582	112	16	54.59	54.59	NUM
admet-2582	112	17	mmae	mmae	NOUN
admet-2582	112	18	20.03±6.62	20.03±6.62	NUM
admet-2582	112	19	0.52±0.108	0.52±0.108	PROPN
admet-2582	112	20	26.90±5.22	26.90±5.22	PROPN
admet-2582	112	21	rc48	rc48	PROPN
admet-2582	112	22	-	-	PUNCT
admet-2582	112	23	adc	adc	PROPN
admet-2582	113	1	ab	ab	PROPN
admet-2582	113	2	8	8	NUM
admet-2582	113	3	mg	mg	PROPN
admet-2582	113	4	kg-1	kg-1	PUNCT
admet-2582	113	5	rc48	rc48	PROPN
admet-2582	113	6	-	-	PUNCT
admet-2582	113	7	adc	adc	PROPN
admet-2582	113	8	ab	ab	PROPN
admet-2582	113	9	185.93±	185.93±	NUM
admet-2582	113	10	56.33	56.33	NUM
admet-2582	113	11	0.02±0.00	0.02±0.00	NOUN
admet-2582	113	12	100.55±12.81	100.55±12.81	NUM
admet-2582	113	13	4603.37±	4603.37±	NUM
admet-2582	113	14	654.59	654.59	NUM
admet-2582	113	15	5170.36±	5170.36±	NUM
admet-2582	113	16	896.82	896.82	NUM
admet-2582	113	17	10.45±	10.45±	NUM
admet-2582	113	18	6.12	6.12	NUM
admet-2582	113	19	428.95±	428.95±	NUM
admet-2582	113	20	176.88	176.88	NUM
admet-2582	113	21	1.59±	1.59±	NUM
admet-2582	113	22	0.29	0.29	NUM
admet-2582	113	23	276.85±	276.85±	NUM
admet-2582	113	24	54.99	54.99	NUM
admet-2582	113	25	mmae	mmae	NOUN
admet-2582	113	26	0.16	0.16	NUM
admet-2582	113	27	mg	mg	PROPN
admet-2582	113	28	kg-1	kg-1	PROPN
admet-2582	113	29	mmae	mmae	VERB
admet-2582	113	30	0.017±0.00	0.017±0.00	NUM
admet-2582	113	31	227.67±103.11	227.67±103.11	NUM
admet-2582	113	32	158.06±	158.06±	NUM
admet-2582	113	33	56.74	56.74	NUM
admet-2582	113	34	note	note	NOUN
admet-2582	113	35	:	:	PUNCT
admet-2582	113	36	aparameter	aparameter	NOUN
admet-2582	113	37	unit	unit	NOUN
admet-2582	113	38	of	of	ADP
admet-2582	113	39	mmae	mmae	PROPN
admet-2582	113	40	was	be	AUX
admet-2582	113	41	ng	ng	PROPN
admet-2582	113	42	ml-1	ml-1	PART
admet-2582	113	43	;	;	PUNCT
admet-2582	113	44	bparameter	bparameter	NOUN
admet-2582	113	45	unit	unit	NOUN
admet-2582	113	46	of	of	ADP
admet-2582	113	47	mmae	mmae	PROPN
admet-2582	113	48	was	be	AUX
admet-2582	113	49	h·ng	h·ng	NUM
admet-2582	113	50	ml-1	ml-1	X
admet-2582	113	51	.	.	PUNCT
admet-2582	114	1	cmax	cmax	VERB
admet-2582	114	2	maximum	maximum	ADJ
admet-2582	114	3	concentration	concentration	NOUN
admet-2582	114	4	,	,	PUNCT
admet-2582	114	5	the	the	DET
admet-2582	114	6	highest	high	ADJ
admet-2582	114	7	concentration	concentration	NOUN
admet-2582	114	8	of	of	ADP
admet-2582	114	9	a	a	DET
admet-2582	114	10	drug	drug	NOUN
admet-2582	114	11	achieved	achieve	VERB
admet-2582	114	12	in	in	ADP
admet-2582	114	13	the	the	DET
admet-2582	114	14	bloodstream	bloodstream	NOUN
admet-2582	114	15	or	or	CCONJ
admet-2582	114	16	a	a	DET
admet-2582	114	17	specific	specific	ADJ
admet-2582	114	18	tissue	tissue	NOUN
admet-2582	114	19	after	after	ADP
admet-2582	114	20	administration	administration	NOUN
admet-2582	114	21	.	.	PUNCT
admet-2582	115	1	auc(0	auc(0	PROPN
admet-2582	115	2	t	t	PROPN
admet-2582	115	3	)	)	PUNCT
admet-2582	115	4	area	area	NOUN
admet-2582	115	5	under	under	ADP
admet-2582	115	6	the	the	DET
admet-2582	115	7	concentration	concentration	NOUN
admet-2582	115	8	-	-	PUNCT
admet-2582	115	9	time	time	NOUN
admet-2582	115	10	curve	curve	NOUN
admet-2582	115	11	from	from	ADP
admet-2582	115	12	time	time	NOUN
admet-2582	115	13	0	0	NUM
admet-2582	115	14	to	to	ADP
admet-2582	115	15	time	time	NOUN
admet-2582	115	16	t	t	NOUN
admet-2582	115	17	;	;	PUNCT
admet-2582	115	18	auc(0	auc(0	ADJ
admet-2582	115	19	-	-	PUNCT
admet-2582	115	20	inf	inf	ADJ
admet-2582	115	21	)	)	PUNCT
admet-2582	115	22	area	area	NOUN
admet-2582	115	23	under	under	ADP
admet-2582	115	24	the	the	DET
admet-2582	115	25	concentration	concentration	NOUN
admet-2582	115	26	-	-	PUNCT
admet-2582	115	27	time	time	NOUN
admet-2582	115	28	curve	curve	NOUN
admet-2582	115	29	from	from	ADP
admet-2582	115	30	time	time	NOUN
admet-2582	115	31	0	0	NUM
admet-2582	115	32	to	to	ADP
admet-2582	115	33	infinity	infinity	NOUN
admet-2582	115	34	)	)	PUNCT
admet-2582	115	35	;	;	PUNCT
admet-2582	115	36	vd	vd	NOUN
admet-2582	115	37	volume	volume	NOUN
admet-2582	115	38	of	of	ADP
admet-2582	115	39	distribution	distribution	NOUN
admet-2582	115	40	,	,	PUNCT
admet-2582	115	41	a	a	DET
admet-2582	115	42	theoretical	theoretical	ADJ
admet-2582	115	43	volume	volume	NOUN
admet-2582	115	44	that	that	PRON
admet-2582	115	45	relates	relate	VERB
admet-2582	115	46	the	the	DET
admet-2582	115	47	amount	amount	NOUN
admet-2582	115	48	of	of	ADP
admet-2582	115	49	drug	drug	NOUN
admet-2582	115	50	in	in	ADP
admet-2582	115	51	the	the	DET
admet-2582	115	52	body	body	NOUN
admet-2582	115	53	to	to	ADP
admet-2582	115	54	the	the	DET
admet-2582	115	55	concentration	concentration	NOUN
admet-2582	115	56	of	of	ADP
admet-2582	115	57	the	the	DET
admet-2582	115	58	drug	drug	NOUN
admet-2582	115	59	in	in	ADP
admet-2582	115	60	the	the	DET
admet-2582	115	61	bloodstream	bloodstream	NOUN
admet-2582	115	62	.	.	PUNCT
admet-2582	116	1	distribution	distribution	NOUN
admet-2582	116	2	overall	overall	NOUN
admet-2582	116	3	,	,	PUNCT
admet-2582	116	4	the	the	DET
admet-2582	116	5	distribution	distribution	NOUN
admet-2582	116	6	of	of	ADP
admet-2582	116	7	the	the	DET
admet-2582	116	8	total	total	ADJ
admet-2582	116	9	radioactivity	radioactivity	NOUN
admet-2582	116	10	was	be	AUX
admet-2582	116	11	similar	similar	ADJ
admet-2582	116	12	to	to	ADP
admet-2582	116	13	that	that	PRON
admet-2582	116	14	of	of	ADP
admet-2582	116	15	the	the	DET
admet-2582	116	16	tca	tca	NOUN
admet-2582	116	17	-	-	PUNCT
admet-2582	116	18	precipitable	precipitable	ADJ
admet-2582	116	19	radioactivity	radioactivity	NOUN
admet-2582	116	20	with	with	ADP
admet-2582	116	21	the	the	DET
admet-2582	116	22	exception	exception	NOUN
admet-2582	116	23	of	of	ADP
admet-2582	116	24	a	a	DET
admet-2582	116	25	few	few	ADJ
admet-2582	116	26	tissues	tissue	NOUN
admet-2582	116	27	/	/	SYM
admet-2582	116	28	body	body	NOUN
admet-2582	116	29	fluids	fluid	NOUN
admet-2582	116	30	(	(	PUNCT
admet-2582	116	31	adrenal	adrenal	ADJ
admet-2582	116	32	gland	gland	NOUN
admet-2582	116	33	,	,	PUNCT
admet-2582	116	34	urinary	urinary	ADJ
admet-2582	116	35	bladder	bladder	NOUN
admet-2582	116	36	)	)	PUNCT
admet-2582	116	37	(	(	PUNCT
admet-2582	116	38	figure	figure	NOUN
admet-2582	116	39	3a	3a	NUM
admet-2582	116	40	,	,	PUNCT
admet-2582	116	41	b	b	NOUN
admet-2582	116	42	)	)	PUNCT
admet-2582	116	43	.	.	PUNCT
admet-2582	117	1	the	the	DET
admet-2582	117	2	exposure	exposure	NOUN
admet-2582	117	3	levels	level	NOUN
admet-2582	117	4	(	(	PUNCT
admet-2582	117	5	aucs	aucs	NOUN
admet-2582	117	6	)	)	PUNCT
admet-2582	117	7	of	of	ADP
admet-2582	117	8	the	the	DET
admet-2582	117	9	tca	tca	PROPN
admet-2582	117	10	-	-	PUNCT
admet-2582	117	11	precipitable	precipitable	ADJ
admet-2582	117	12	radioactivity	radioactivity	NOUN
admet-2582	117	13	in	in	ADP
admet-2582	117	14	the	the	DET
admet-2582	117	15	tissues	tissue	NOUN
admet-2582	117	16	can	can	AUX
admet-2582	117	17	be	be	AUX
admet-2582	117	18	ranked	rank	VERB
admet-2582	117	19	from	from	ADP
admet-2582	117	20	high	high	ADJ
admet-2582	117	21	to	to	PART
admet-2582	117	22	low	low	VERB
admet-2582	117	23	in	in	ADP
admet-2582	117	24	the	the	DET
admet-2582	117	25	following	follow	VERB
admet-2582	117	26	order	order	NOUN
admet-2582	117	27	:	:	PUNCT
admet-2582	117	28	serum	serum	NOUN
admet-2582	117	29	,	,	PUNCT
admet-2582	117	30	tumour	tumour	NOUN
admet-2582	117	31	,	,	PUNCT
admet-2582	117	32	liver	liver	NOUN
admet-2582	117	33	,	,	PUNCT
admet-2582	117	34	adrenal	adrenal	ADJ
admet-2582	117	35	glands	gland	NOUN
admet-2582	117	36	,	,	PUNCT
admet-2582	117	37	kidneys	kidney	NOUN
admet-2582	117	38	,	,	PUNCT
admet-2582	117	39	lungs	lung	NOUN
admet-2582	117	40	,	,	PUNCT
admet-2582	117	41	urine	urine	NOUN
admet-2582	117	42	,	,	PUNCT
admet-2582	117	43	submandibular	submandibular	ADJ
admet-2582	117	44	gland	gland	NOUN
admet-2582	117	45	,	,	PUNCT
admet-2582	117	46	gonads	gonad	NOUN
admet-2582	117	47	,	,	PUNCT
admet-2582	117	48	lymph	lymph	NOUN
admet-2582	117	49	nodes	node	NOUN
admet-2582	117	50	,	,	PUNCT
admet-2582	117	51	spleen	spleen	NOUN
admet-2582	117	52	,	,	PUNCT
admet-2582	117	53	heart	heart	NOUN
admet-2582	117	54	,	,	PUNCT
admet-2582	117	55	bladder	bladder	NOUN
admet-2582	117	56	,	,	PUNCT
admet-2582	117	57	small	small	ADJ
admet-2582	117	58	intestine	intestine	NOUN
admet-2582	117	59	,	,	PUNCT
admet-2582	117	60	adipose	adipose	ADJ
admet-2582	117	61	tissue	tissue	NOUN
admet-2582	117	62	,	,	PUNCT
admet-2582	117	63	muscle	muscle	NOUN
admet-2582	117	64	,	,	PUNCT
admet-2582	117	65	pancreas	pancrea	NOUN
admet-2582	117	66	,	,	PUNCT
admet-2582	117	67	eyeballs	eyeball	NOUN
admet-2582	117	68	,	,	PUNCT
admet-2582	117	69	intestinal	intestinal	ADJ
admet-2582	117	70	faeces	faece	NOUN
admet-2582	117	71	,	,	PUNCT
admet-2582	117	72	intestinal	intestinal	ADJ
admet-2582	117	73	contents	content	NOUN
admet-2582	117	74	,	,	PUNCT
admet-2582	117	75	brain	brain	NOUN
admet-2582	117	76	and	and	CCONJ
admet-2582	117	77	bone	bone	NOUN
admet-2582	117	78	marrow	marrow	NOUN
admet-2582	117	79	(	(	PUNCT
admet-2582	117	80	figure	figure	VERB
admet-2582	117	81	3c	3c	NUM
admet-2582	117	82	)	)	PUNCT
admet-2582	117	83	.	.	PUNCT
admet-2582	118	1	conversely	conversely	ADV
admet-2582	118	2	,	,	PUNCT
admet-2582	118	3	the	the	DET
admet-2582	118	4	tca	tca	NOUN
admet-2582	118	5	-	-	PUNCT
admet-2582	118	6	precipitable	precipitable	ADJ
admet-2582	118	7	radioactivity	radioactivity	NOUN
admet-2582	118	8	in	in	ADP
admet-2582	118	9	the	the	DET
admet-2582	118	10	blood	blood	NOUN
admet-2582	118	11	accounted	account	VERB
admet-2582	118	12	for	for	ADP
admet-2582	118	13	approximately	approximately	ADV
admet-2582	118	14	90	90	NUM
admet-2582	118	15	%	%	NOUN
admet-2582	118	16	of	of	ADP
admet-2582	118	17	the	the	DET
admet-2582	118	18	total	total	ADJ
admet-2582	118	19	radioactivity	radioactivity	NOUN
admet-2582	118	20	.	.	PUNCT
admet-2582	119	1	the	the	DET
admet-2582	119	2	shplc	shplc	PROPN
admet-2582	119	3	analysis	analysis	NOUN
admet-2582	119	4	also	also	ADV
admet-2582	119	5	showed	show	VERB
admet-2582	119	6	that	that	SCONJ
admet-2582	119	7	125i	125i	NOUN
admet-2582	119	8	–	–	PUNCT
admet-2582	119	9	rc48	rc48	PROPN
admet-2582	119	10	-	-	PUNCT
admet-2582	119	11	adc	adc	PROPN
admet-2582	119	12	is	be	AUX
admet-2582	119	13	the	the	DET
admet-2582	119	14	main	main	ADJ
admet-2582	119	15	form	form	NOUN
admet-2582	119	16	that	that	PRON
admet-2582	119	17	exists	exist	VERB
admet-2582	119	18	in	in	ADP
admet-2582	119	19	the	the	DET
admet-2582	119	20	serum	serum	NOUN
admet-2582	119	21	and	and	CCONJ
admet-2582	119	22	no	no	DET
admet-2582	119	23	125i	125i	NOUN
admet-2582	119	24	–	–	PUNCT
admet-2582	119	25	rc48	rc48	PROPN
admet-2582	119	26	-	-	PUNCT
admet-2582	119	27	adc	adc	PROPN
admet-2582	119	28	and	and	CCONJ
admet-2582	119	29	plasma	plasma	NOUN
admet-2582	119	30	protein	protein	NOUN
admet-2582	119	31	conjugate	conjugate	ADJ
admet-2582	119	32	or	or	CCONJ
admet-2582	119	33	other	other	ADJ
admet-2582	119	34	metabolite	metabolite	NOUN
admet-2582	119	35	was	be	AUX
admet-2582	119	36	detected	detect	VERB
admet-2582	119	37	,	,	PUNCT
admet-2582	119	38	which	which	PRON
admet-2582	119	39	indicates	indicate	VERB
admet-2582	119	40	that	that	SCONJ
admet-2582	119	41	the	the	DET
admet-2582	119	42	drug	drug	NOUN
admet-2582	119	43	exists	exist	VERB
admet-2582	119	44	mainly	mainly	ADV
admet-2582	119	45	in	in	ADP
admet-2582	119	46	its	its	PRON
admet-2582	119	47	original	original	ADJ
admet-2582	119	48	form	form	NOUN
admet-2582	119	49	in	in	ADP
admet-2582	119	50	the	the	DET
admet-2582	119	51	blood	blood	NOUN
admet-2582	119	52	.	.	PUNCT
admet-2582	120	1	moreover	moreover	ADV
admet-2582	120	2	,	,	PUNCT
admet-2582	120	3	the	the	DET
admet-2582	120	4	tissues	tissue	NOUN
admet-2582	120	5	and	and	CCONJ
admet-2582	120	6	organs	organ	NOUN
admet-2582	120	7	rich	rich	ADJ
admet-2582	120	8	in	in	ADP
admet-2582	120	9	blood	blood	NOUN
admet-2582	120	10	flow	flow	NOUN
admet-2582	120	11	(	(	PUNCT
admet-2582	120	12	such	such	ADJ
admet-2582	120	13	as	as	ADP
admet-2582	120	14	the	the	DET
admet-2582	120	15	adrenal	adrenal	ADJ
admet-2582	120	16	gland	gland	NOUN
admet-2582	120	17	,	,	PUNCT
admet-2582	120	18	liver	liver	NOUN
admet-2582	120	19	,	,	PUNCT
admet-2582	120	20	kidneys	kidney	NOUN
admet-2582	120	21	,	,	PUNCT
admet-2582	120	22	and	and	CCONJ
admet-2582	120	23	lungs	lung	NOUN
admet-2582	120	24	)	)	PUNCT
admet-2582	120	25	had	have	VERB
admet-2582	120	26	higher	high	ADJ
admet-2582	120	27	radioactivity	radioactivity	NOUN
admet-2582	120	28	(	(	PUNCT
admet-2582	120	29	figure	figure	NOUN
admet-2582	120	30	3c	3c	NUM
admet-2582	120	31	)	)	PUNCT
admet-2582	120	32	.	.	PUNCT
admet-2582	121	1	the	the	DET
admet-2582	121	2	radioactivity	radioactivity	NOUN
admet-2582	121	3	distribution	distribution	NOUN
admet-2582	121	4	was	be	AUX
admet-2582	121	5	less	less	ADJ
admet-2582	121	6	in	in	ADP
admet-2582	121	7	tissues	tissue	NOUN
admet-2582	121	8	and	and	CCONJ
admet-2582	121	9	organs	organ	NOUN
admet-2582	121	10	with	with	ADP
admet-2582	121	11	poorer	poor	ADJ
admet-2582	121	12	perfusion	perfusion	NOUN
admet-2582	121	13	(	(	PUNCT
admet-2582	121	14	such	such	ADJ
admet-2582	121	15	as	as	ADP
admet-2582	121	16	muscle	muscle	NOUN
admet-2582	121	17	and	and	CCONJ
admet-2582	121	18	adipose	adipose	ADJ
admet-2582	121	19	tissue	tissue	NOUN
admet-2582	121	20	)	)	PUNCT
admet-2582	121	21	.	.	PUNCT
admet-2582	122	1	the	the	DET
admet-2582	122	2	relatively	relatively	ADV
admet-2582	122	3	low	low	ADJ
admet-2582	122	4	radioactive	radioactive	ADJ
admet-2582	122	5	concentration	concentration	NOUN
admet-2582	122	6	of	of	ADP
admet-2582	122	7	the	the	DET
admet-2582	122	8	test	test	NOUN
admet-2582	122	9	article	article	NOUN
admet-2582	122	10	in	in	ADP
admet-2582	122	11	the	the	DET
admet-2582	122	12	brain	brain	NOUN
admet-2582	122	13	suggests	suggest	VERB
admet-2582	122	14	that	that	SCONJ
admet-2582	122	15	it	it	PRON
admet-2582	122	16	does	do	AUX
admet-2582	122	17	not	not	PART
admet-2582	122	18	pass	pass	VERB
admet-2582	122	19	the	the	DET
admet-2582	122	20	blood	blood	NOUN
admet-2582	122	21	-	-	PUNCT
admet-2582	122	22	brain	brain	NOUN
admet-2582	122	23	barrier	barrier	NOUN
admet-2582	122	24	easily	easily	ADV
admet-2582	122	25	.	.	PUNCT
admet-2582	123	1	it	it	PRON
admet-2582	123	2	is	be	AUX
admet-2582	123	3	worth	worth	ADJ
admet-2582	123	4	noting	note	VERB
admet-2582	123	5	that	that	SCONJ
admet-2582	123	6	the	the	DET
admet-2582	123	7	radioactive	radioactive	ADJ
admet-2582	123	8	concentration	concentration	NOUN
admet-2582	123	9	at	at	ADP
admet-2582	123	10	the	the	DET
admet-2582	123	11	tumour	tumour	NOUN
admet-2582	123	12	site	site	NOUN
admet-2582	123	13	was	be	AUX
admet-2582	123	14	relatively	relatively	ADV
admet-2582	123	15	high	high	ADJ
admet-2582	123	16	,	,	PUNCT
admet-2582	123	17	suggesting	suggest	VERB
admet-2582	123	18	that	that	SCONJ
admet-2582	123	19	rc48	rc48	PROPN
admet-2582	123	20	-	-	PUNCT
admet-2582	123	21	adc	adc	PROPN
admet-2582	123	22	may	may	AUX
admet-2582	123	23	possess	possess	VERB
admet-2582	123	24	excellent	excellent	ADJ
admet-2582	123	25	targeting	targeting	NOUN
admet-2582	123	26	.	.	PUNCT
admet-2582	124	1	considering	consider	VERB
admet-2582	124	2	that	that	SCONJ
admet-2582	124	3	the	the	DET
admet-2582	124	4	study	study	NOUN
admet-2582	124	5	on	on	ADP
admet-2582	124	6	tissue	tissue	NOUN
admet-2582	124	7	distribution	distribution	NOUN
admet-2582	124	8	in	in	ADP
admet-2582	124	9	tumour	tumour	NOUN
admet-2582	124	10	-	-	PUNCT
admet-2582	124	11	bearing	bear	VERB
admet-2582	124	12	mice	mouse	NOUN
admet-2582	124	13	can	can	AUX
admet-2582	124	14	better	well	ADV
admet-2582	124	15	reflect	reflect	VERB
admet-2582	124	16	the	the	DET
admet-2582	124	17	distribution	distribution	NOUN
admet-2582	124	18	of	of	ADP
admet-2582	124	19	rc48	rc48	PROPN
admet-2582	124	20	-	-	PUNCT
admet-2582	124	21	adc	adc	PROPN
admet-2582	124	22	in	in	ADP
admet-2582	124	23	vivo	vivo	NOUN
admet-2582	124	24	and	and	CCONJ
admet-2582	124	25	tumour	tumour	NOUN
admet-2582	124	26	targeting	target	VERB
admet-2582	124	27	in	in	ADP
admet-2582	124	28	the	the	DET
admet-2582	124	29	presence	presence	NOUN
admet-2582	124	30	of	of	ADP
admet-2582	124	31	tumour	tumour	NOUN
admet-2582	124	32	,	,	PUNCT
admet-2582	124	33	the	the	DET
admet-2582	124	34	tissue	tissue	NOUN
admet-2582	124	35	distribution	distribution	NOUN
admet-2582	124	36	experiments	experiment	NOUN
admet-2582	124	37	in	in	ADP
admet-2582	124	38	this	this	DET
admet-2582	124	39	study	study	NOUN
admet-2582	124	40	were	be	AUX
admet-2582	124	41	carried	carry	VERB
admet-2582	124	42	out	out	ADP
admet-2582	124	43	in	in	ADP
admet-2582	124	44	tumour	tumour	NOUN
admet-2582	124	45	-	-	PUNCT
admet-2582	124	46	bearing	bear	VERB
admet-2582	124	47	mice	mouse	NOUN
admet-2582	124	48	.	.	PUNCT
admet-2582	125	1	from	from	ADP
admet-2582	125	2	the	the	DET
admet-2582	125	3	tissue	tissue	NOUN
admet-2582	125	4	distribution	distribution	NOUN
admet-2582	125	5	study	study	NOUN
admet-2582	125	6	of	of	ADP
admet-2582	125	7	125i	125i	PROPN
admet-2582	125	8	-	-	PUNCT
admet-2582	125	9	rc48	rc48	PROPN
admet-2582	125	10	-	-	PUNCT
admet-2582	125	11	adc	adc	PROPN
admet-2582	125	12	,	,	PUNCT
admet-2582	125	13	we	we	PRON
admet-2582	125	14	found	find	VERB
admet-2582	125	15	that	that	SCONJ
admet-2582	125	16	rc48	rc48	PROPN
admet-2582	125	17	-	-	PUNCT
admet-2582	125	18	adc	adc	PROPN
admet-2582	125	19	was	be	AUX
admet-2582	125	20	present	present	ADJ
admet-2582	125	21	in	in	ADP
admet-2582	125	22	the	the	DET
admet-2582	125	23	blood	blood	NOUN
admet-2582	125	24	mainly	mainly	ADV
admet-2582	125	25	in	in	ADP
admet-2582	125	26	the	the	DET
admet-2582	125	27	form	form	NOUN
admet-2582	125	28	of	of	ADP
admet-2582	125	29	a	a	DET
admet-2582	125	30	prototype	prototype	NOUN
admet-2582	125	31	drug	drug	NOUN
admet-2582	125	32	,	,	PUNCT
admet-2582	125	33	and	and	CCONJ
admet-2582	125	34	it	it	PRON
admet-2582	125	35	's	be	AUX
admet-2582	125	36	easier	easy	ADJ
admet-2582	125	37	to	to	PART
admet-2582	125	38	distribute	distribute	VERB
admet-2582	125	39	to	to	ADP
admet-2582	125	40	the	the	DET
admet-2582	125	41	tissues	tissue	NOUN
admet-2582	125	42	and	and	CCONJ
admet-2582	125	43	organs	organ	NOUN
admet-2582	125	44	that	that	PRON
admet-2582	125	45	are	be	AUX
admet-2582	125	46	rich	rich	ADJ
admet-2582	125	47	in	in	ADP
admet-2582	125	48	blood	blood	NOUN
admet-2582	125	49	flow	flow	NOUN
admet-2582	125	50	and	and	CCONJ
admet-2582	125	51	it	it	PRON
admet-2582	125	52	's	be	AUX
admet-2582	125	53	harder	hard	ADJ
admet-2582	125	54	to	to	PART
admet-2582	125	55	cross	cross	VERB
admet-2582	125	56	the	the	DET
admet-2582	125	57	blood	blood	NOUN
admet-2582	125	58	-	-	PUNCT
admet-2582	125	59	brain	brain	NOUN
admet-2582	125	60	barrier	barrier	NOUN
admet-2582	125	61	.	.	PUNCT
admet-2582	126	1	the	the	DET
admet-2582	126	2	total	total	ADJ
admet-2582	126	3	radioactivity	radioactivity	NOUN
admet-2582	126	4	was	be	AUX
admet-2582	126	5	very	very	ADV
admet-2582	126	6	high	high	ADJ
admet-2582	126	7	,	,	PUNCT
admet-2582	126	8	but	but	CCONJ
admet-2582	126	9	the	the	DET
admet-2582	126	10	tca	tca	PROPN
admet-2582	126	11	-	-	PUNCT
admet-2582	126	12	precipitable	precipitable	ADJ
admet-2582	126	13	radioactivity	radioactivity	NOUN
admet-2582	126	14	was	be	AUX
admet-2582	126	15	low	low	ADJ
admet-2582	126	16	in	in	ADP
admet-2582	126	17	the	the	DET
admet-2582	126	18	urinary	urinary	ADJ
admet-2582	126	19	bladder	bladder	NOUN
admet-2582	126	20	,	,	PUNCT
admet-2582	126	21	suggesting	suggest	VERB
admet-2582	126	22	that	that	SCONJ
admet-2582	126	23	a	a	DET
admet-2582	126	24	large	large	ADJ
admet-2582	126	25	amount	amount	NOUN
admet-2582	126	26	of	of	ADP
admet-2582	126	27	125i	125i	PROPN
admet-2582	126	28	rc48	rc48	PROPN
admet-2582	126	29	-	-	PUNCT
admet-2582	126	30	adc	adc	PROPN
admet-2582	126	31	was	be	AUX
admet-2582	126	32	degraded	degrade	VERB
admet-2582	126	33	in	in	ADP
admet-2582	126	34	the	the	DET
admet-2582	126	35	adrenal	adrenal	ADJ
admet-2582	126	36	gland	gland	NOUN
admet-2582	126	37	.	.	PUNCT
admet-2582	127	1	the	the	DET
admet-2582	127	2	acid	acid	NOUN
admet-2582	127	3	-	-	PUNCT
admet-2582	127	4	precipitable	precipitable	ADJ
admet-2582	127	5	radioactivity	radioactivity	NOUN
admet-2582	127	6	of	of	ADP
admet-2582	127	7	125i	125i	PROPN
admet-2582	127	8	-	-	PUNCT
admet-2582	127	9	rc48	rc48	PROPN
admet-2582	127	10	-	-	PUNCT
admet-2582	127	11	adc	adc	PROPN
admet-2582	127	12	in	in	ADP
admet-2582	127	13	the	the	DET
admet-2582	127	14	bladder	bladder	NOUN
admet-2582	127	15	and	and	CCONJ
admet-2582	127	16	kidneys	kidney	NOUN
admet-2582	127	17	was	be	AUX
admet-2582	127	18	high	high	ADJ
admet-2582	127	19	,	,	PUNCT
admet-2582	127	20	whereas	whereas	SCONJ
admet-2582	127	21	it	it	PRON
admet-2582	127	22	was	be	AUX
admet-2582	127	23	very	very	ADV
admet-2582	127	24	low	low	ADJ
admet-2582	127	25	in	in	ADP
admet-2582	127	26	the	the	DET
admet-2582	127	27	small	small	ADJ
admet-2582	127	28	intestinal	intestinal	ADJ
admet-2582	127	29	and	and	CCONJ
admet-2582	127	30	intestinal	intestinal	ADJ
admet-2582	127	31	contents	content	NOUN
admet-2582	127	32	,	,	PUNCT
admet-2582	127	33	which	which	PRON
admet-2582	127	34	means	mean	VERB
admet-2582	127	35	that	that	SCONJ
admet-2582	127	36	metabolites	metabolite	NOUN
admet-2582	127	37	of	of	ADP
admet-2582	127	38	125i	125i	NOUN
admet-2582	127	39	-	-	PUNCT
admet-2582	127	40	rc48	rc48	PROPN
admet-2582	127	41	-	-	PUNCT
admet-2582	127	42	adc	adc	PROPN
admet-2582	127	43	may	may	AUX
admet-2582	127	44	be	be	AUX
admet-2582	127	45	present	present	ADJ
admet-2582	127	46	in	in	ADP
admet-2582	127	47	urine	urine	NOUN
admet-2582	127	48	.	.	PUNCT
admet-2582	128	1	this	this	PRON
admet-2582	128	2	was	be	AUX
admet-2582	128	3	also	also	ADV
admet-2582	128	4	confirmed	confirm	VERB
admet-2582	128	5	in	in	ADP
admet-2582	128	6	admet	admet	PROPN
admet-2582	128	7	&	&	CCONJ
admet-2582	128	8	dmpk	dmpk	PROPN
admet-2582	128	9	13(2	13(2	PROPN
admet-2582	128	10	)	)	PUNCT
admet-2582	128	11	(	(	PUNCT
admet-2582	128	12	2025	2025	NUM
admet-2582	128	13	)	)	PUNCT
admet-2582	128	14	2582	2582	NUM
admet-2582	128	15	disitamab	disitamab	VERB
admet-2582	128	16	vedotin	vedotin	ADJ
admet-2582	128	17	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	128	18	,	,	PUNCT
admet-2582	128	19	distribution	distribution	NOUN
admet-2582	128	20	and	and	CCONJ
admet-2582	128	21	metabolism	metabolism	NOUN
admet-2582	128	22	doi	doi	NOUN
admet-2582	128	23	:	:	PUNCT
admet-2582	128	24	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	128	25	7	7	NUM
admet-2582	128	26	the	the	DET
admet-2582	128	27	excretion	excretion	NOUN
admet-2582	128	28	experiment	experiment	NOUN
admet-2582	128	29	.	.	PUNCT
admet-2582	129	1	last	last	ADJ
admet-2582	129	2	but	but	CCONJ
admet-2582	129	3	not	not	PART
admet-2582	129	4	least	least	ADJ
admet-2582	129	5	,	,	PUNCT
admet-2582	129	6	rc48	rc48	PROPN
admet-2582	129	7	-	-	PUNCT
admet-2582	129	8	adc	adc	PROPN
admet-2582	129	9	shows	show	VERB
admet-2582	129	10	excellent	excellent	ADJ
admet-2582	129	11	targeting	targeting	NOUN
admet-2582	129	12	capability	capability	NOUN
admet-2582	129	13	with	with	ADP
admet-2582	129	14	a	a	DET
admet-2582	129	15	very	very	ADV
admet-2582	129	16	high	high	ADJ
admet-2582	129	17	radioactive	radioactive	ADJ
admet-2582	129	18	concentration	concentration	NOUN
admet-2582	129	19	of	of	ADP
admet-2582	129	20	125i	125i	PROPN
admet-2582	129	21	-	-	PUNCT
admet-2582	129	22	rc48	rc48	PROPN
admet-2582	129	23	-	-	PUNCT
admet-2582	129	24	adc	adc	PROPN
admet-2582	129	25	at	at	ADP
admet-2582	129	26	the	the	DET
admet-2582	129	27	tumour	tumour	NOUN
admet-2582	129	28	site	site	NOUN
admet-2582	129	29	,	,	PUNCT
admet-2582	129	30	either	either	CCONJ
admet-2582	129	31	the	the	DET
admet-2582	129	32	total	total	ADJ
admet-2582	129	33	or	or	CCONJ
admet-2582	129	34	tca	tca	ADJ
admet-2582	129	35	-	-	PUNCT
admet-2582	129	36	precipitable	precipitable	ADJ
admet-2582	129	37	radioactivity	radioactivity	NOUN
admet-2582	129	38	.	.	PUNCT
admet-2582	130	1	a	a	DET
admet-2582	130	2	b	b	NOUN
admet-2582	130	3	c	c	NOUN
admet-2582	130	4	auc0	auc0	PROPN
admet-2582	130	5	-	-	PUNCT
admet-2582	130	6	t	t	PROPN
admet-2582	130	7	,	,	PUNCT
admet-2582	130	8	g	g	PROPN
admet-2582	130	9	h	h	PROPN
admet-2582	130	10	g-1	g-1	NOUN
admet-2582	130	11	or	or	CCONJ
admet-2582	130	12	g	g	PROPN
admet-2582	130	13	h	h	NOUN
admet-2582	130	14	ml-1	ml-1	NOUN
admet-2582	130	15	figure	figure	VERB
admet-2582	130	16	3	3	NUM
admet-2582	130	17	.	.	PUNCT
admet-2582	130	18	tissue	tissue	NOUN
admet-2582	130	19	distribution	distribution	NOUN
admet-2582	130	20	of	of	ADP
admet-2582	130	21	[	[	X
admet-2582	130	22	125i]–rc48	125i]–rc48	NUM
admet-2582	130	23	-	-	PUNCT
admet-2582	130	24	adc	adc	NOUN
admet-2582	130	25	following	follow	VERB
admet-2582	130	26	a	a	DET
admet-2582	130	27	single	single	ADJ
admet-2582	130	28	i.v	i.v	PROPN
admet-2582	130	29	.	.	PROPN
admet-2582	130	30	bolus	bolus	PROPN
admet-2582	130	31	administration	administration	NOUN
admet-2582	130	32	of	of	ADP
admet-2582	130	33	12	12	NUM
admet-2582	130	34	mg	mg	PROPN
admet-2582	130	35	/	/	SYM
admet-2582	130	36	kg	kg	PROPN
admet-2582	130	37	(	(	PUNCT
admet-2582	130	38	mean	mean	PROPN
admet-2582	130	39	±	±	NUM
admet-2582	130	40	sd	sd	NOUN
admet-2582	130	41	,	,	PUNCT
admet-2582	130	42	n	n	NOUN
admet-2582	130	43	=	=	SYM
admet-2582	130	44	5	5	NUM
admet-2582	130	45	per	per	ADP
admet-2582	130	46	time	time	NOUN
admet-2582	130	47	point	point	NOUN
admet-2582	130	48	per	per	ADP
admet-2582	130	49	group	group	NOUN
admet-2582	130	50	)	)	PUNCT
admet-2582	130	51	.	.	PUNCT
admet-2582	131	1	(	(	PUNCT
admet-2582	131	2	a	a	X
admet-2582	131	3	)	)	PUNCT
admet-2582	131	4	tissue	tissue	NOUN
admet-2582	131	5	concentrations	concentration	NOUN
admet-2582	131	6	of	of	ADP
admet-2582	131	7	radioactivity	radioactivity	NOUN
admet-2582	131	8	by	by	ADP
admet-2582	131	9	total	total	ADJ
admet-2582	131	10	radioactivity	radioactivity	NOUN
admet-2582	131	11	method	method	NOUN
admet-2582	131	12	;	;	PUNCT
admet-2582	131	13	(	(	PUNCT
admet-2582	131	14	b	b	X
admet-2582	131	15	)	)	PUNCT
admet-2582	131	16	tissue	tissue	NOUN
admet-2582	131	17	concentrations	concentration	NOUN
admet-2582	131	18	of	of	ADP
admet-2582	131	19	radioactivity	radioactivity	NOUN
admet-2582	131	20	by	by	ADP
admet-2582	131	21	tca	tca	PROPN
admet-2582	131	22	-	-	PUNCT
admet-2582	131	23	precipitable	precipitable	ADJ
admet-2582	131	24	radioactivity	radioactivity	NOUN
admet-2582	131	25	method	method	NOUN
admet-2582	131	26	;	;	PUNCT
admet-2582	131	27	(	(	PUNCT
admet-2582	131	28	c	c	X
admet-2582	131	29	)	)	PUNCT
admet-2582	131	30	tissue	tissue	NOUN
admet-2582	131	31	exposure	exposure	NOUN
admet-2582	131	32	(	(	PUNCT
admet-2582	131	33	auc0	auc0	PROPN
admet-2582	131	34	-	-	PUNCT
admet-2582	131	35	t	t	PROPN
admet-2582	131	36	)	)	PUNCT
admet-2582	131	37	blood	blood	NOUN
admet-2582	131	38	bra	bra	NOUN
admet-2582	131	39	in	in	ADP
admet-2582	131	40	tumor	tumor	NOUN
admet-2582	131	41	fat	fat	PROPN
admet-2582	131	42	skeleta	skeleta	PROPN
admet-2582	131	43	l	l	PROPN
admet-2582	131	44	m	m	VERB
admet-2582	131	45	usc	usc	PROPN
admet-2582	131	46	le	le	X
admet-2582	131	47	repro	repro	ADJ
admet-2582	131	48	ducti	ducti	NOUN
admet-2582	131	49	ve	ve	PROPN
admet-2582	131	50	org	org	X
admet-2582	131	51	ans	ans	PROPN
admet-2582	131	52	adre	adre	PROPN
admet-2582	131	53	nal	nal	PROPN
admet-2582	131	54	g	g	PROPN
admet-2582	131	55	land	land	NOUN
admet-2582	131	56	ly	ly	ADP
admet-2582	131	57	mph	mph	NOUN
admet-2582	131	58	nodes	node	NOUN
admet-2582	131	59	inte	inte	VERB
admet-2582	131	60	sti	sti	PROPN
admet-2582	131	61	nal	nal	PROPN
admet-2582	131	62	c	c	PROPN
admet-2582	131	63	onte	onte	NOUN
admet-2582	131	64	nt	not	PART
admet-2582	131	65	small	small	ADJ
admet-2582	132	1	i	i	PROPN
admet-2582	132	2	nte	nte	PROPN
admet-2582	132	3	sti	sti	PROPN
admet-2582	132	4	ne	ne	PROPN
admet-2582	132	5	speen	speen	PROPN
admet-2582	132	6	pancre	pancre	PROPN
admet-2582	132	7	as	as	SCONJ
admet-2582	132	8	liv	liv	PROPN
admet-2582	132	9	ers	er	VERB
admet-2582	132	10	kidneys	kidney	NOUN
admet-2582	132	11	urin	urin	PROPN
admet-2582	132	12	ary	ary	ADJ
admet-2582	132	13	bladder	bladder	NOUN
admet-2582	132	14	submandibular	submandibular	NOUN
admet-2582	132	15	g	g	PROPN
admet-2582	132	16	land	land	NOUN
admet-2582	132	17	eyes	eye	NOUN
admet-2582	132	18	lu	lu	PROPN
admet-2582	132	19	ngs	ng	VERB
admet-2582	132	20	heart	heart	NOUN
admet-2582	132	21	bone	bone	NOUN
admet-2582	132	22	m	m	NOUN
admet-2582	132	23	arro	arro	VERB
admet-2582	132	24	w	w	ADP
admet-2582	132	25	0	0	NUM
admet-2582	132	26	3	3	NUM
admet-2582	132	27	6	6	NUM
admet-2582	132	28	9	9	NUM
admet-2582	132	29	12	12	NUM
admet-2582	132	30	tc	tc	NOUN
admet-2582	132	31	a	a	DET
admet-2582	132	32	ra	ra	NOUN
admet-2582	132	33	di	di	NOUN
admet-2582	133	1	oa	oa	INTJ
admet-2582	133	2	ct	ct	PROPN
admet-2582	133	3	iv	iv	NUM
admet-2582	133	4	ity	ity	PROPN
admet-2582	133	5	μ	μ	PROPN
admet-2582	133	6	g﹒	g﹒	PROPN
admet-2582	133	7	eq	eq	NOUN
admet-2582	133	8	v/	v/	PROPN
admet-2582	133	9	g	g	PROPN
admet-2582	133	10	or	or	CCONJ
admet-2582	133	11	μ	μ	NUM
admet-2582	133	12	g﹒	g﹒	PROPN
admet-2582	133	13	eq	eq	NOUN
admet-2582	134	1	v/	v/	PROPN
admet-2582	134	2	m	m	PROPN
admet-2582	134	3	l	l	NOUN
admet-2582	134	4	4	4	NUM
admet-2582	134	5	hr	hr	NOUN
admet-2582	134	6	24	24	NUM
admet-2582	134	7	hr	hr	NOUN
admet-2582	134	8	72	72	NUM
admet-2582	134	9	hr	hr	NOUN
admet-2582	134	10	168	168	NUM
admet-2582	134	11	hr	hr	NOUN
admet-2582	134	12	blood	blood	NOUN
admet-2582	134	13	bra	bra	NOUN
admet-2582	134	14	in	in	ADP
admet-2582	134	15	tumor	tumor	NOUN
admet-2582	134	16	fat	fat	PROPN
admet-2582	134	17	skeleta	skeleta	PROPN
admet-2582	134	18	l	l	PROPN
admet-2582	134	19	m	m	VERB
admet-2582	134	20	usc	usc	PROPN
admet-2582	134	21	le	le	X
admet-2582	134	22	repro	repro	ADJ
admet-2582	134	23	ducti	ducti	NOUN
admet-2582	134	24	ve	ve	PROPN
admet-2582	134	25	org	org	X
admet-2582	134	26	ans	ans	PROPN
admet-2582	134	27	adre	adre	PROPN
admet-2582	134	28	nal	nal	PROPN
admet-2582	134	29	g	g	PROPN
admet-2582	134	30	land	land	NOUN
admet-2582	134	31	ly	ly	ADP
admet-2582	134	32	mph	mph	NOUN
admet-2582	134	33	nodes	node	NOUN
admet-2582	134	34	inte	inte	VERB
admet-2582	134	35	sti	sti	PROPN
admet-2582	134	36	nal	nal	PROPN
admet-2582	134	37	c	c	PROPN
admet-2582	134	38	onte	onte	NOUN
admet-2582	134	39	nt	not	PART
admet-2582	134	40	small	small	ADJ
admet-2582	135	1	i	i	PROPN
admet-2582	135	2	nte	nte	PROPN
admet-2582	135	3	sti	sti	PROPN
admet-2582	135	4	ne	ne	PROPN
admet-2582	135	5	speen	speen	PROPN
admet-2582	135	6	pancre	pancre	PROPN
admet-2582	135	7	as	as	SCONJ
admet-2582	135	8	liv	liv	PROPN
admet-2582	135	9	ers	er	VERB
admet-2582	135	10	kidneys	kidney	NOUN
admet-2582	135	11	urin	urin	PROPN
admet-2582	135	12	ary	ary	ADJ
admet-2582	135	13	bladder	bladder	NOUN
admet-2582	135	14	submandibular	submandibular	NOUN
admet-2582	135	15	g	g	PROPN
admet-2582	135	16	land	land	NOUN
admet-2582	135	17	eyes	eye	NOUN
admet-2582	135	18	lu	lu	PROPN
admet-2582	135	19	ngs	ng	VERB
admet-2582	135	20	heart	heart	NOUN
admet-2582	135	21	bone	bone	NOUN
admet-2582	135	22	m	m	NOUN
admet-2582	135	23	arro	arro	VERB
admet-2582	135	24	w	w	ADP
admet-2582	135	25	0	0	NUM
admet-2582	135	26	3	3	NUM
admet-2582	135	27	6	6	NUM
admet-2582	135	28	9	9	NUM
admet-2582	135	29	12	12	NUM
admet-2582	135	30	to	to	ADP
admet-2582	135	31	ta	ta	ADP
admet-2582	135	32	l	l	NOUN
admet-2582	135	33	r	r	NOUN
admet-2582	135	34	ad	ad	NOUN
admet-2582	135	35	io	io	X
admet-2582	135	36	ac	ac	PROPN
admet-2582	136	1	tiv	tiv	PROPN
admet-2582	136	2	ity	ity	PROPN
admet-2582	136	3	μ	μ	PROPN
admet-2582	136	4	g﹒	g﹒	PROPN
admet-2582	136	5	eq	eq	NOUN
admet-2582	136	6	v/	v/	PROPN
admet-2582	136	7	g	g	PROPN
admet-2582	136	8	or	or	CCONJ
admet-2582	136	9	μ	μ	NUM
admet-2582	136	10	g﹒	g﹒	PROPN
admet-2582	136	11	eq	eq	NOUN
admet-2582	136	12	v/	v/	PROPN
admet-2582	136	13	m	m	PROPN
admet-2582	136	14	l	l	NOUN
admet-2582	136	15	4	4	NUM
admet-2582	136	16	hr	hr	NOUN
admet-2582	136	17	24	24	NUM
admet-2582	136	18	hr	hr	NOUN
admet-2582	136	19	72	72	NUM
admet-2582	136	20	hr	hr	NOUN
admet-2582	136	21	168	168	NUM
admet-2582	136	22	hr	hr	NOUN
admet-2582	136	23	bone	bone	NOUN
admet-2582	136	24	marrow	marrow	NOUN
admet-2582	136	25	brain	brain	NOUN
admet-2582	136	26	intestinal	intestinal	ADJ
admet-2582	136	27	content	content	NOUN
admet-2582	136	28	skeletal	skeletal	ADJ
admet-2582	136	29	muscle	muscle	NOUN
admet-2582	136	30	fat	fat	ADJ
admet-2582	136	31	eyes	eye	NOUN
admet-2582	136	32	pancreas	pancreas	VERB
admet-2582	136	33	small	small	ADJ
admet-2582	136	34	intestine	intestine	NOUN
admet-2582	136	35	lymph	lymph	NOUN
admet-2582	136	36	nodes	node	NOUN
admet-2582	136	37	speen	speen	VERB
admet-2582	136	38	heart	heart	NOUN
admet-2582	136	39	reproductive	reproductive	ADJ
admet-2582	136	40	organs	organ	NOUN
admet-2582	136	41	submandibular	submandibular	ADJ
admet-2582	136	42	gland	gland	NOUN
admet-2582	136	43	lungs	lung	VERB
admet-2582	136	44	urinary	urinary	ADJ
admet-2582	136	45	bladder	bladder	NOUN
admet-2582	136	46	kidneys	kidney	NOUN
admet-2582	136	47	livers	liver	NOUN
admet-2582	136	48	blood	blood	NOUN
admet-2582	136	49	tumor	tumor	NOUN
admet-2582	136	50	adrenal	adrenal	ADJ
admet-2582	136	51	gland	gland	NOUN
admet-2582	136	52	0	0	NUM
admet-2582	137	1	100	100	NUM
admet-2582	137	2	200	200	NUM
admet-2582	137	3	300	300	NUM
admet-2582	137	4	400	400	NUM
admet-2582	137	5	500	500	NUM
admet-2582	137	6	600	600	NUM
admet-2582	137	7	700	700	NUM
admet-2582	137	8	auc	auc	NOUN
admet-2582	137	9	0	0	NUM
admet-2582	137	10	-	-	PUNCT
admet-2582	137	11	t	t	NOUN
admet-2582	137	12	(	(	PUNCT
admet-2582	137	13	μg﹒hr	μg﹒hr	PROPN
admet-2582	137	14	/	/	SYM
admet-2582	137	15	g	g	PROPN
admet-2582	137	16	or	or	CCONJ
admet-2582	137	17	μg﹒hr	μg﹒hr	NUM
admet-2582	137	18	/	/	SYM
admet-2582	137	19	ml	ml	NOUN
admet-2582	137	20	)	)	PUNCT
admet-2582	137	21	tca	tca	ADJ
admet-2582	137	22	-	-	PUNCT
admet-2582	137	23	precipitable	precipitable	ADJ
admet-2582	137	24	radioactivity	radioactivity	NOUN
admet-2582	137	25	total	total	NOUN
admet-2582	137	26	radioactivity	radioactivity	NOUN
admet-2582	137	27	tc	tc	ADP
admet-2582	137	28	a	a	DET
admet-2582	137	29	r	r	NOUN
admet-2582	137	30	ad	ad	NOUN
admet-2582	137	31	io	io	X
admet-2582	137	32	ak	ak	PROPN
admet-2582	137	33	ti	ti	PROPN
admet-2582	137	34	vi	vi	PROPN
admet-2582	137	35	ty	ty	INTJ
admet-2582	137	36	,	,	PUNCT
admet-2582	137	37			NOUN
admet-2582	137	38	g	g	NOUN
admet-2582	137	39	eq	eq	NOUN
admet-2582	137	40	v/	v/	PROPN
admet-2582	137	41	g	g	NOUN
admet-2582	137	42	o	o	NOUN
admet-2582	137	43	r	r	NOUN
admet-2582	137	44			NOUN
admet-2582	137	45	g	g	NOUN
admet-2582	137	46	e	e	NOUN
admet-2582	137	47	q	q	PROPN
admet-2582	137	48	v/	v/	PROPN
admet-2582	137	49	m	m	NOUN
admet-2582	137	50	l	l	NOUN
admet-2582	137	51	tc	tc	NOUN
admet-2582	137	52	a	a	DET
admet-2582	137	53	r	r	NOUN
admet-2582	137	54	ad	ad	NOUN
admet-2582	137	55	io	io	X
admet-2582	137	56	ak	ak	PROPN
admet-2582	137	57	ti	ti	PROPN
admet-2582	137	58	vi	vi	PROPN
admet-2582	137	59	ty	ty	INTJ
admet-2582	137	60	,	,	PUNCT
admet-2582	137	61			NOUN
admet-2582	137	62	g	g	NOUN
admet-2582	137	63	eq	eq	NOUN
admet-2582	137	64	v/	v/	PROPN
admet-2582	137	65	g	g	NOUN
admet-2582	137	66	o	o	NOUN
admet-2582	137	67	r	r	NOUN
admet-2582	137	68			NOUN
admet-2582	137	69	g	g	NOUN
admet-2582	137	70	e	e	NOUN
admet-2582	137	71	q	q	PROPN
admet-2582	137	72	v/	v/	PROPN
admet-2582	137	73	m	m	PROPN
admet-2582	137	74	l	l	NOUN
admet-2582	137	75	4	4	NUM
admet-2582	137	76	h	h	NOUN
admet-2582	137	77	24	24	NUM
admet-2582	137	78	72	72	NUM
admet-2582	137	79	h	h	NOUN
admet-2582	137	80	168	168	NUM
admet-2582	137	81	h	h	NOUN
admet-2582	137	82	4	4	NUM
admet-2582	137	83	h	h	NOUN
admet-2582	137	84	24	24	NUM
admet-2582	137	85	72	72	NUM
admet-2582	137	86	h	h	NOUN
admet-2582	137	87	168	168	NUM
admet-2582	137	88	h	h	NOUN
admet-2582	137	89	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	137	90	m.	m.	NOUN
admet-2582	137	91	das	das	PROPN
admet-2582	137	92	et	et	PROPN
admet-2582	137	93	al	al	PROPN
admet-2582	137	94	.	.	PROPN
admet-2582	137	95	admet	admet	PROPN
admet-2582	137	96	&	&	CCONJ
admet-2582	137	97	dmpk	dmpk	PROPN
admet-2582	137	98	13(2	13(2	PROPN
admet-2582	137	99	)	)	PUNCT
admet-2582	137	100	(	(	PUNCT
admet-2582	137	101	2025	2025	NUM
admet-2582	137	102	)	)	PUNCT
admet-2582	137	103	2582	2582	NUM
admet-2582	137	104	8	8	NUM
admet-2582	138	1	the	the	DET
admet-2582	138	2	total	total	NOUN
admet-2582	138	3	and	and	CCONJ
admet-2582	138	4	acn	acn	PROPN
admet-2582	138	5	-	-	PUNCT
admet-2582	138	6	extract	extract	NOUN
admet-2582	138	7	fraction	fraction	NOUN
admet-2582	138	8	radioactivity	radioactivity	NOUN
admet-2582	138	9	results	result	NOUN
admet-2582	138	10	of	of	ADP
admet-2582	138	11	radioactive	radioactive	ADJ
admet-2582	138	12	concentrations	concentration	NOUN
admet-2582	138	13	at	at	ADP
admet-2582	138	14	various	various	ADJ
admet-2582	138	15	time	time	NOUN
admet-2582	138	16	points	point	NOUN
admet-2582	138	17	(	(	PUNCT
admet-2582	138	18	figure	figure	NOUN
admet-2582	138	19	4a	4a	NUM
admet-2582	138	20	,	,	PUNCT
admet-2582	138	21	b	b	X
admet-2582	138	22	)	)	PUNCT
admet-2582	138	23	showed	show	VERB
admet-2582	138	24	that	that	SCONJ
admet-2582	138	25	with	with	ADP
admet-2582	138	26	time	time	NOUN
admet-2582	138	27	,	,	PUNCT
admet-2582	138	28	the	the	DET
admet-2582	138	29	fm	fm	PROPN
admet-2582	138	30	in	in	ADP
admet-2582	138	31	plasma	plasma	NOUN
admet-2582	138	32	decreased	decrease	VERB
admet-2582	138	33	,	,	PUNCT
admet-2582	138	34	while	while	SCONJ
admet-2582	138	35	it	it	PRON
admet-2582	138	36	in	in	ADP
admet-2582	138	37	tissues	tissue	NOUN
admet-2582	138	38	and	and	CCONJ
admet-2582	138	39	tumours	tumour	NOUN
admet-2582	138	40	increased	increase	VERB
admet-2582	138	41	significantly	significantly	ADV
admet-2582	138	42	,	,	PUNCT
admet-2582	138	43	the	the	DET
admet-2582	138	44	fm	fm	NOUN
admet-2582	138	45	in	in	ADP
admet-2582	138	46	the	the	DET
admet-2582	138	47	spleen	spleen	NOUN
admet-2582	138	48	,	,	PUNCT
admet-2582	138	49	kidney	kidney	NOUN
admet-2582	138	50	,	,	PUNCT
admet-2582	138	51	lung	lung	NOUN
admet-2582	138	52	,	,	PUNCT
admet-2582	138	53	and	and	CCONJ
admet-2582	138	54	heart	heart	NOUN
admet-2582	138	55	peaked	peak	VERB
admet-2582	138	56	at	at	ADP
admet-2582	138	57	24	24	NUM
admet-2582	138	58	hours	hour	NOUN
admet-2582	138	59	,	,	PUNCT
admet-2582	138	60	and	and	CCONJ
admet-2582	138	61	the	the	DET
admet-2582	138	62	fm	fm	NOUN
admet-2582	138	63	in	in	ADP
admet-2582	138	64	tumours	tumour	NOUN
admet-2582	138	65	peaked	peak	VERB
admet-2582	138	66	at	at	ADP
admet-2582	138	67	72	72	NUM
admet-2582	138	68	hours	hour	NOUN
admet-2582	138	69	.	.	PUNCT
admet-2582	139	1	in	in	ADP
admet-2582	139	2	other	other	ADJ
admet-2582	139	3	tissues	tissue	NOUN
admet-2582	139	4	and	and	CCONJ
admet-2582	139	5	tumours	tumour	NOUN
admet-2582	139	6	,	,	PUNCT
admet-2582	139	7	it	it	PRON
admet-2582	139	8	peaked	peak	VERB
admet-2582	139	9	at	at	ADP
admet-2582	139	10	4	4	NUM
admet-2582	139	11	hours	hour	NOUN
admet-2582	139	12	and	and	CCONJ
admet-2582	139	13	24	24	NUM
admet-2582	139	14	hours	hour	NOUN
admet-2582	139	15	,	,	PUNCT
admet-2582	139	16	respectively	respectively	ADV
admet-2582	139	17	,	,	PUNCT
admet-2582	139	18	which	which	PRON
admet-2582	139	19	were	be	AUX
admet-2582	139	20	lower	low	ADJ
admet-2582	139	21	than	than	ADP
admet-2582	139	22	the	the	DET
admet-2582	139	23	same	same	ADJ
admet-2582	139	24	time	time	NOUN
admet-2582	139	25	point	point	NOUN
admet-2582	139	26	in	in	ADP
admet-2582	139	27	plasma	plasma	NOUN
admet-2582	139	28	,	,	PUNCT
admet-2582	139	29	and	and	CCONJ
admet-2582	139	30	the	the	DET
admet-2582	139	31	peak	peak	NOUN
admet-2582	139	32	concentration	concentration	NOUN
admet-2582	139	33	of	of	ADP
admet-2582	139	34	radioactivity	radioactivity	NOUN
admet-2582	139	35	in	in	ADP
admet-2582	139	36	the	the	DET
admet-2582	139	37	tumour	tumour	NOUN
admet-2582	139	38	was	be	AUX
admet-2582	139	39	about	about	ADV
admet-2582	139	40	52.67	52.67	NUM
admet-2582	139	41	%	%	NOUN
admet-2582	139	42	of	of	ADP
admet-2582	139	43	the	the	DET
admet-2582	139	44	same	same	ADJ
admet-2582	139	45	time	time	NOUN
admet-2582	139	46	point	point	NOUN
admet-2582	139	47	in	in	ADP
admet-2582	139	48	plasma	plasma	NOUN
admet-2582	139	49	.	.	PUNCT
admet-2582	140	1	in	in	ADP
admet-2582	140	2	addition	addition	NOUN
admet-2582	140	3	,	,	PUNCT
admet-2582	140	4	the	the	DET
admet-2582	140	5	tumour	tumour	NOUN
admet-2582	140	6	radiation	radiation	NOUN
admet-2582	140	7	concentration	concentration	NOUN
admet-2582	140	8	at	at	ADP
admet-2582	140	9	the	the	DET
admet-2582	140	10	last	last	ADJ
admet-2582	140	11	collection	collection	NOUN
admet-2582	140	12	point	point	NOUN
admet-2582	140	13	(	(	PUNCT
admet-2582	140	14	336	336	NUM
admet-2582	140	15	h	h	NOUN
admet-2582	140	16	)	)	PUNCT
admet-2582	140	17	was	be	AUX
admet-2582	140	18	the	the	DET
admet-2582	140	19	highest	high	ADJ
admet-2582	140	20	,	,	PUNCT
admet-2582	140	21	about	about	ADV
admet-2582	140	22	1.93	1.93	NUM
admet-2582	140	23	times	time	NOUN
admet-2582	140	24	the	the	DET
admet-2582	140	25	plasma	plasma	NOUN
admet-2582	140	26	concentration	concentration	NOUN
admet-2582	140	27	at	at	ADP
admet-2582	140	28	the	the	DET
admet-2582	140	29	same	same	ADJ
admet-2582	140	30	time	time	NOUN
admet-2582	140	31	point	point	NOUN
admet-2582	140	32	.	.	PUNCT
admet-2582	141	1	a	a	DET
admet-2582	141	2	b	b	NOUN
admet-2582	141	3	c	c	NOUN
admet-2582	141	4	auc0	auc0	PROPN
admet-2582	141	5	-	-	PUNCT
admet-2582	141	6	t	t	PROPN
admet-2582	141	7	,	,	PUNCT
admet-2582	141	8	g	g	PROPN
admet-2582	141	9	h	h	PROPN
admet-2582	141	10	g-1	g-1	NOUN
admet-2582	141	11	or	or	CCONJ
admet-2582	141	12	g	g	PROPN
admet-2582	141	13	h	h	NOUN
admet-2582	141	14	ml-1	ml-1	ADV
admet-2582	141	15	auc0	auc0	PROPN
admet-2582	141	16	-	-	PUNCT
admet-2582	141	17	t	t	PROPN
admet-2582	141	18	,	,	PUNCT
admet-2582	141	19	g	g	PROPN
admet-2582	141	20	h	h	PROPN
admet-2582	141	21	g-1	g-1	NOUN
admet-2582	141	22	or	or	CCONJ
admet-2582	141	23	g	g	PROPN
admet-2582	142	1	h	h	NOUN
admet-2582	142	2	ml-1	ml-1	NOUN
admet-2582	142	3	figure	figure	VERB
admet-2582	142	4	4	4	NUM
admet-2582	142	5	.	.	PUNCT
admet-2582	142	6	tissue	tissue	NOUN
admet-2582	142	7	distribution	distribution	NOUN
admet-2582	142	8	of	of	ADP
admet-2582	142	9	[	[	PUNCT
admet-2582	142	10	3h	3h	NUM
admet-2582	142	11	-	-	PUNCT
admet-2582	142	12	mmae]-rc48	mmae]-rc48	NOUN
admet-2582	142	13	-	-	PUNCT
admet-2582	142	14	adc	adc	NOUN
admet-2582	142	15	following	follow	VERB
admet-2582	142	16	a	a	DET
admet-2582	142	17	single	single	ADJ
admet-2582	142	18	i.v	i.v	PROPN
admet-2582	142	19	.	.	PUNCT
admet-2582	142	20	dose	dose	PROPN
admet-2582	142	21	of	of	ADP
admet-2582	142	22	12	12	NUM
admet-2582	142	23	mg	mg	PROPN
admet-2582	142	24	/	/	SYM
admet-2582	142	25	kg	kg	PROPN
admet-2582	142	26	(	(	PUNCT
admet-2582	142	27	mean	mean	PROPN
admet-2582	142	28	±	±	NUM
admet-2582	142	29	sd	sd	NOUN
admet-2582	142	30	,	,	PUNCT
admet-2582	142	31	n	n	PROPN
admet-2582	142	32	=	=	NUM
admet-2582	142	33	6	6	NUM
admet-2582	142	34	per	per	ADP
admet-2582	142	35	time	time	NOUN
admet-2582	142	36	point	point	NOUN
admet-2582	142	37	per	per	ADP
admet-2582	142	38	group	group	NOUN
admet-2582	142	39	)	)	PUNCT
admet-2582	142	40	.	.	PUNCT
admet-2582	143	1	(	(	PUNCT
admet-2582	143	2	a	a	X
admet-2582	143	3	)	)	PUNCT
admet-2582	143	4	tissue	tissue	NOUN
admet-2582	143	5	concentrations	concentration	NOUN
admet-2582	143	6	of	of	ADP
admet-2582	143	7	radioactivity	radioactivity	NOUN
admet-2582	143	8	by	by	ADP
admet-2582	143	9	total	total	ADJ
admet-2582	143	10	radioactivity	radioactivity	NOUN
admet-2582	143	11	method	method	NOUN
admet-2582	143	12	;	;	PUNCT
admet-2582	143	13	(	(	PUNCT
admet-2582	143	14	b	b	X
admet-2582	143	15	)	)	PUNCT
admet-2582	143	16	tissue	tissue	NOUN
admet-2582	143	17	concentrations	concentration	NOUN
admet-2582	143	18	of	of	ADP
admet-2582	143	19	radioactivity	radioactivity	NOUN
admet-2582	143	20	by	by	ADP
admet-2582	143	21	acn	acn	PROPN
admet-2582	143	22	-	-	PUNCT
admet-2582	143	23	extract	extract	NOUN
admet-2582	143	24	radioactivity	radioactivity	NOUN
admet-2582	143	25	method	method	NOUN
admet-2582	143	26	;	;	PUNCT
admet-2582	143	27	(	(	PUNCT
admet-2582	143	28	c	c	X
admet-2582	143	29	)	)	PUNCT
admet-2582	143	30	tissue	tissue	NOUN
admet-2582	143	31	exposure	exposure	NOUN
admet-2582	143	32	(	(	PUNCT
admet-2582	143	33	auc0	auc0	PROPN
admet-2582	143	34	-	-	PUNCT
admet-2582	143	35	t	t	PROPN
admet-2582	143	36	)	)	PUNCT
admet-2582	143	37	blo	blo	NOUN
admet-2582	143	38	od	od	PROPN
admet-2582	143	39	adre	adre	PROPN
admet-2582	143	40	nal	nal	PROPN
admet-2582	143	41	g	g	PROPN
admet-2582	143	42	la	la	PROPN
admet-2582	143	43	nd	nd	NOUN
admet-2582	143	44	lu	lu	PROPN
admet-2582	143	45	ngs	ng	NOUN
admet-2582	143	46	bone	bone	NOUN
admet-2582	143	47	m	m	PROPN
admet-2582	143	48	ar	ar	PROPN
admet-2582	143	49	ro	ro	PROPN
admet-2582	143	50	w	w	PROPN
admet-2582	143	51	tu	tu	PROPN
admet-2582	143	52	m	m	PROPN
admet-2582	143	53	or	or	CCONJ
admet-2582	143	54	liv	liv	PROPN
admet-2582	143	55	er	er	INTJ
admet-2582	143	56	ova	ova	X
admet-2582	144	1	ry	ry	NOUN
admet-2582	144	2	kid	kid	PROPN
admet-2582	144	3	ney	ney	PROPN
admet-2582	144	4	s	s	PROPN
admet-2582	144	5	ute	ute	PROPN
admet-2582	144	6	ru	ru	PROPN
admet-2582	144	7	s	s	PROPN
admet-2582	144	8	ly	ly	ADP
admet-2582	144	9	m	m	VERB
admet-2582	144	10	ph	ph	NOUN
admet-2582	144	11	n	n	PRON
admet-2582	144	12	odes	ode	VERB
admet-2582	144	13	in	in	ADP
admet-2582	144	14	te	te	PROPN
admet-2582	144	15	st	st	PROPN
admet-2582	144	16	in	in	ADP
admet-2582	144	17	al	al	PROPN
admet-2582	144	18	w	w	PROPN
admet-2582	144	19	al	al	PROPN
admet-2582	144	20	l	l	PROPN
admet-2582	144	21	hea	hea	PROPN
admet-2582	144	22	rt	rt	PROPN
admet-2582	144	23	sp	sp	ADP
admet-2582	144	24	le	le	X
admet-2582	144	25	ensk	ensk	PROPN
admet-2582	144	26	in	in	ADP
admet-2582	144	27	sa	sa	PROPN
admet-2582	144	28	liv	liv	PROPN
admet-2582	144	29	ar	ar	PROPN
admet-2582	144	30	y	y	PROPN
admet-2582	144	31	g	g	PROPN
admet-2582	144	32	la	la	PROPN
admet-2582	144	33	nd	nd	PROPN
admet-2582	144	34	st	st	PROPN
admet-2582	144	35	om	om	PROPN
admet-2582	144	36	ac	ac	PROPN
admet-2582	144	37	h	h	PROPN
admet-2582	144	38	w	w	PROPN
admet-2582	144	39	al	al	PROPN
admet-2582	144	40	l	l	PROPN
admet-2582	145	1	te	te	PROPN
admet-2582	145	2	st	st	PROPN
admet-2582	145	3	is	be	AUX
admet-2582	145	4	bone	bone	NOUN
admet-2582	145	5	pan	pan	NOUN
admet-2582	145	6	cr	cr	PROPN
admet-2582	145	7	ea	ea	PROPN
admet-2582	145	8	s	s	PROPN
admet-2582	145	9	urin	urin	PROPN
admet-2582	145	10	ar	ar	PROPN
admet-2582	145	11	y	y	PROPN
admet-2582	145	12	b	b	PROPN
admet-2582	145	13	la	la	PROPN
admet-2582	145	14	dder	dder	PROPN
admet-2582	145	15	ep	ep	PROPN
admet-2582	146	1	i	i	PROPN
admet-2582	146	2	d	d	PROPN
admet-2582	147	1	i	i	PROPN
admet-2582	148	1	d	d	NOUN
admet-2582	149	1	ym	ym	PROPN
admet-2582	150	1	is	be	AUX
admet-2582	150	2	fa	fa	INTJ
admet-2582	150	3	t	t	NOUN
admet-2582	150	4	ey	ey	INTJ
admet-2582	150	5	es	es	X
admet-2582	150	6	sk	sk	INTJ
admet-2582	150	7	el	el	PROPN
admet-2582	150	8	et	et	PROPN
admet-2582	150	9	al	al	PROPN
admet-2582	150	10	m	m	PROPN
admet-2582	150	11	usc	usc	PROPN
admet-2582	150	12	le	le	X
admet-2582	150	13	bra	bra	NOUN
admet-2582	150	14	in	in	ADP
admet-2582	150	15	0	0	NUM
admet-2582	151	1	10	10	NUM
admet-2582	151	2	20	20	NUM
admet-2582	151	3	30	30	NUM
admet-2582	151	4	40	40	NUM
admet-2582	151	5	50	50	NUM
admet-2582	151	6	120	120	NUM
admet-2582	151	7	t	t	NOUN
admet-2582	151	8	o	o	X
admet-2582	151	9	ta	ta	X
admet-2582	151	10	l	l	NOUN
admet-2582	151	11	r	r	NOUN
admet-2582	152	1	a	a	PROPN
admet-2582	152	2	d	d	X
admet-2582	152	3	io	io	PROPN
admet-2582	152	4	a	a	DET
admet-2582	152	5	ct	ct	NOUN
admet-2582	152	6	iv	iv	NUM
admet-2582	152	7	it	it	PRON
admet-2582	153	1	y	y	PROPN
admet-2582	153	2	μ	μ	NUM
admet-2582	153	3	g	g	NOUN
admet-2582	153	4	﹒	﹒	X
admet-2582	153	5	e	e	NOUN
admet-2582	153	6	q	q	PROPN
admet-2582	153	7	v/	v/	NOUN
admet-2582	154	1	g	g	NOUN
admet-2582	154	2	o	o	NOUN
admet-2582	154	3	r	r	NOUN
admet-2582	154	4	μ	μ	PROPN
admet-2582	154	5	g	g	NOUN
admet-2582	154	6	﹒	﹒	X
admet-2582	154	7	e	e	NOUN
admet-2582	154	8	q	q	PROPN
admet-2582	154	9	v/	v/	PROPN
admet-2582	154	10	m	m	VERB
admet-2582	154	11	l	l	NOUN
admet-2582	154	12	4	4	NUM
admet-2582	154	13	hr	hr	NOUN
admet-2582	154	14	24	24	NUM
admet-2582	154	15	hr	hr	NOUN
admet-2582	154	16	72	72	NUM
admet-2582	154	17	hr	hr	NOUN
admet-2582	154	18	168	168	NUM
admet-2582	154	19	hr	hr	NOUN
admet-2582	154	20	336	336	NUM
admet-2582	154	21	hr	hr	NOUN
admet-2582	154	22	tu	tu	PROPN
admet-2582	154	23	m	m	PROPN
admet-2582	154	24	or	or	CCONJ
admet-2582	154	25	liv	liv	PROPN
admet-2582	154	26	er	er	INTJ
admet-2582	154	27	s	s	X
admet-2582	154	28	sp	sp	ADP
admet-2582	154	29	le	le	X
admet-2582	154	30	en	en	X
admet-2582	154	31	blo	blo	PROPN
admet-2582	154	32	od	od	ADP
admet-2582	154	33	kid	kid	NOUN
admet-2582	154	34	ney	ney	NOUN
admet-2582	154	35	s	s	PART
admet-2582	154	36	lu	lu	PROPN
admet-2582	154	37	ngs	ng	VERB
admet-2582	154	38	hea	hea	PROPN
admet-2582	154	39	rt	rt	PROPN
admet-2582	154	40	0	0	NUM
admet-2582	154	41	2	2	NUM
admet-2582	154	42	4	4	NUM
admet-2582	154	43	6	6	NUM
admet-2582	154	44	8	8	NUM
admet-2582	154	45	10	10	NUM
admet-2582	154	46	12	12	NUM
admet-2582	154	47	14	14	NUM
admet-2582	154	48	16	16	NUM
admet-2582	154	49	18	18	NUM
admet-2582	154	50	a	a	DET
admet-2582	154	51	c	c	NOUN
admet-2582	155	1	n	n	ADP
admet-2582	155	2	r	r	NOUN
admet-2582	155	3	a	a	PROPN
admet-2582	155	4	d	d	X
admet-2582	155	5	io	io	PROPN
admet-2582	156	1	a	a	PRON
admet-2582	157	1	ct	ct	NOUN
admet-2582	158	1	iv	iv	NUM
admet-2582	159	1	it	it	PRON
admet-2582	160	1	y	y	PROPN
admet-2582	160	2	μ	μ	NUM
admet-2582	160	3	g	g	NOUN
admet-2582	160	4	﹒	﹒	X
admet-2582	160	5	e	e	NOUN
admet-2582	160	6	q	q	PROPN
admet-2582	160	7	v/	v/	NOUN
admet-2582	161	1	g	g	NOUN
admet-2582	161	2	o	o	NOUN
admet-2582	161	3	r	r	NOUN
admet-2582	161	4	μ	μ	PROPN
admet-2582	161	5	g	g	NOUN
admet-2582	161	6	﹒	﹒	X
admet-2582	161	7	e	e	NOUN
admet-2582	161	8	q	q	PROPN
admet-2582	161	9	v/	v/	PROPN
admet-2582	161	10	m	m	VERB
admet-2582	161	11	l	l	NOUN
admet-2582	161	12	4	4	NUM
admet-2582	161	13	hr	hr	NOUN
admet-2582	161	14	24	24	NUM
admet-2582	161	15	hr	hr	NOUN
admet-2582	161	16	72	72	NUM
admet-2582	161	17	hr	hr	NOUN
admet-2582	161	18	168	168	NUM
admet-2582	161	19	hr	hr	NOUN
admet-2582	161	20	336	336	NUM
admet-2582	161	21	hr	hr	NOUN
admet-2582	161	22	brain	brain	NOUN
admet-2582	161	23	skeletal	skeletal	ADJ
admet-2582	161	24	muscle	muscle	NOUN
admet-2582	161	25	eyes	eye	NOUN
admet-2582	161	26	bone	bone	NOUN
admet-2582	161	27	fat	fat	ADJ
admet-2582	161	28	stomach	stomach	NOUN
admet-2582	161	29	wall	wall	PROPN
admet-2582	161	30	pancreas	pancreas	PROPN
admet-2582	161	31	heart	heart	NOUN
admet-2582	161	32	epididymis	epididymis	PROPN
admet-2582	161	33	intestinal	intestinal	PROPN
admet-2582	161	34	wall	wall	PROPN
admet-2582	161	35	lymph	lymph	NOUN
admet-2582	161	36	nodes	nod	VERB
admet-2582	161	37	testis	testis	NOUN
admet-2582	161	38	spleen	spleen	NOUN
admet-2582	161	39	salivary	salivary	ADJ
admet-2582	161	40	gland	gland	NOUN
admet-2582	161	41	urinary	urinary	ADJ
admet-2582	161	42	bladder	bladder	NOUN
admet-2582	161	43	skin	skin	NOUN
admet-2582	161	44	kidneys	kidney	NOUN
admet-2582	161	45	bone	bone	NOUN
admet-2582	161	46	marrow	marrow	NOUN
admet-2582	161	47	ovary	ovary	ADJ
admet-2582	161	48	adrenal	adrenal	ADJ
admet-2582	161	49	gland	gland	NOUN
admet-2582	161	50	uterus	uterus	NOUN
admet-2582	161	51	lungs	lung	NOUN
admet-2582	161	52	liver	liver	NOUN
admet-2582	161	53	tumor	tumor	NOUN
admet-2582	161	54	blood	blood	NOUN
admet-2582	161	55	0	0	NUM
admet-2582	161	56	1000	1000	NUM
admet-2582	161	57	2000	2000	NUM
admet-2582	161	58	3000	3000	NUM
admet-2582	161	59	4000	4000	NUM
admet-2582	161	60	5000	5000	NUM
admet-2582	161	61	total	total	NOUN
admet-2582	161	62	radioactivity	radioactivity	NOUN
admet-2582	161	63	auc	auc	NOUN
admet-2582	161	64	0	0	NUM
admet-2582	161	65	-	-	PUNCT
admet-2582	161	66	t	t	NOUN
admet-2582	161	67	(	(	PUNCT
admet-2582	161	68	μg﹒hr	μg﹒hr	PROPN
admet-2582	161	69	/	/	SYM
admet-2582	161	70	g	g	PROPN
admet-2582	161	71	or	or	CCONJ
admet-2582	161	72	μg﹒hr	μg﹒hr	NUM
admet-2582	161	73	/	/	SYM
admet-2582	161	74	ml	ml	NOUN
admet-2582	161	75	)	)	PUNCT
admet-2582	161	76	heart	heart	NOUN
admet-2582	161	77	spleen	spleen	NOUN
admet-2582	161	78	kidneys	kidney	NOUN
admet-2582	161	79	lungs	lung	VERB
admet-2582	161	80	liver	liver	NOUN
admet-2582	161	81	tumor	tumor	NOUN
admet-2582	161	82	blood	blood	NOUN
admet-2582	161	83	0	0	NUM
admet-2582	161	84	500	500	NUM
admet-2582	161	85	1000	1000	NUM
admet-2582	161	86	1500	1500	NUM
admet-2582	161	87	2000	2000	NUM
admet-2582	161	88	2500	2500	NUM
admet-2582	161	89	auc	auc	NOUN
admet-2582	161	90	0	0	NUM
admet-2582	161	91	-	-	PUNCT
admet-2582	161	92	t	t	NOUN
admet-2582	161	93	(	(	PUNCT
admet-2582	161	94	μg﹒hr	μg﹒hr	PROPN
admet-2582	161	95	/	/	SYM
admet-2582	161	96	g	g	PROPN
admet-2582	161	97	or	or	CCONJ
admet-2582	161	98	μg﹒hr	μg﹒hr	NUM
admet-2582	161	99	/	/	SYM
admet-2582	161	100	ml	ml	NOUN
admet-2582	161	101	)	)	PUNCT
admet-2582	161	102	acn	acn	PROPN
admet-2582	161	103	radioactivity	radioactivity	NOUN
admet-2582	161	104	to	to	ADP
admet-2582	161	105	ta	ta	ADP
admet-2582	161	106	l	l	NOUN
admet-2582	161	107	r	r	NOUN
admet-2582	161	108	ad	ad	NOUN
admet-2582	161	109	io	io	X
admet-2582	161	110	ak	ak	PROPN
admet-2582	161	111	ti	ti	PROPN
admet-2582	161	112	vi	vi	PROPN
admet-2582	161	113	ty	ty	INTJ
admet-2582	161	114	,	,	PUNCT
admet-2582	161	115			NOUN
admet-2582	161	116	g	g	NOUN
admet-2582	161	117	eq	eq	NOUN
admet-2582	161	118	v/	v/	PROPN
admet-2582	162	1	g	g	NOUN
admet-2582	162	2	o	o	NOUN
admet-2582	162	3	r	r	NOUN
admet-2582	162	4			NOUN
admet-2582	162	5	g	g	NOUN
admet-2582	162	6	eq	eq	PROPN
admet-2582	162	7	v/	v/	PROPN
admet-2582	162	8	m	m	PROPN
admet-2582	162	9	l	l	NOUN
admet-2582	162	10	a	a	DET
admet-2582	162	11	c	c	NOUN
admet-2582	162	12	n	n	NOUN
admet-2582	162	13	r	r	NOUN
admet-2582	162	14	ad	ad	NOUN
admet-2582	162	15	io	io	X
admet-2582	162	16	ak	ak	PROPN
admet-2582	162	17	ti	ti	PROPN
admet-2582	162	18	vi	vi	PROPN
admet-2582	162	19	ty	ty	INTJ
admet-2582	162	20	,	,	PUNCT
admet-2582	162	21			NOUN
admet-2582	162	22	g	g	NOUN
admet-2582	162	23	eq	eq	NOUN
admet-2582	162	24	v/	v/	PROPN
admet-2582	163	1	g	g	NOUN
admet-2582	163	2	o	o	NOUN
admet-2582	163	3	r	r	NOUN
admet-2582	163	4			NOUN
admet-2582	163	5	g	g	NOUN
admet-2582	163	6	eq	eq	PROPN
admet-2582	163	7	v/	v/	PROPN
admet-2582	163	8	m	m	PROPN
admet-2582	163	9	l	l	NOUN
admet-2582	163	10	4	4	NUM
admet-2582	163	11	h	h	NOUN
admet-2582	163	12	24	24	NUM
admet-2582	163	13	72	72	NUM
admet-2582	163	14	h	h	NOUN
admet-2582	163	15	168	168	NUM
admet-2582	163	16	h	h	NOUN
admet-2582	163	17	336	336	NUM
admet-2582	163	18	h	h	NOUN
admet-2582	163	19	4	4	NUM
admet-2582	163	20	h	h	NOUN
admet-2582	163	21	24	24	NUM
admet-2582	163	22	72	72	NUM
admet-2582	163	23	h	h	NOUN
admet-2582	163	24	168	168	NUM
admet-2582	163	25	h	h	NOUN
admet-2582	163	26	336	336	NUM
admet-2582	163	27	h	h	NOUN
admet-2582	163	28	admet	admet	PROPN
admet-2582	163	29	&	&	CCONJ
admet-2582	163	30	dmpk	dmpk	PROPN
admet-2582	163	31	13(2	13(2	PROPN
admet-2582	163	32	)	)	PUNCT
admet-2582	163	33	(	(	PUNCT
admet-2582	163	34	2025	2025	NUM
admet-2582	163	35	)	)	PUNCT
admet-2582	163	36	2582	2582	NUM
admet-2582	163	37	disitamab	disitamab	VERB
admet-2582	163	38	vedotin	vedotin	ADJ
admet-2582	163	39	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	163	40	,	,	PUNCT
admet-2582	163	41	distribution	distribution	NOUN
admet-2582	163	42	and	and	CCONJ
admet-2582	163	43	metabolism	metabolism	NOUN
admet-2582	163	44	doi	doi	NOUN
admet-2582	163	45	:	:	PUNCT
admet-2582	163	46	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	163	47	9	9	NUM
admet-2582	163	48	meanwhile	meanwhile	ADV
admet-2582	163	49	,	,	PUNCT
admet-2582	163	50	according	accord	VERB
admet-2582	163	51	to	to	ADP
admet-2582	163	52	the	the	DET
admet-2582	163	53	total	total	ADJ
admet-2582	163	54	radioactivity	radioactivity	NOUN
admet-2582	163	55	auc0	auc0	PROPN
admet-2582	163	56	-	-	PUNCT
admet-2582	163	57	t	t	PROPN
admet-2582	163	58	from	from	ADP
admet-2582	163	59	high	high	ADJ
admet-2582	163	60	to	to	ADP
admet-2582	163	61	low	low	ADJ
admet-2582	163	62	tissues	tissue	NOUN
admet-2582	163	63	/	/	SYM
admet-2582	163	64	fluids	fluid	NOUN
admet-2582	163	65	were	be	AUX
admet-2582	163	66	the	the	DET
admet-2582	163	67	tumours	tumour	NOUN
admet-2582	163	68	,	,	PUNCT
admet-2582	163	69	whole	whole	ADJ
admet-2582	163	70	blood	blood	NOUN
admet-2582	163	71	,	,	PUNCT
admet-2582	163	72	liver	liver	NOUN
admet-2582	163	73	,	,	PUNCT
admet-2582	163	74	lung	lung	NOUN
admet-2582	163	75	,	,	PUNCT
admet-2582	163	76	uterus	uterus	NOUN
admet-2582	163	77	,	,	PUNCT
admet-2582	163	78	adrenal	adrenal	ADJ
admet-2582	163	79	gland	gland	NOUN
admet-2582	163	80	,	,	PUNCT
admet-2582	163	81	ovary	ovary	ADJ
admet-2582	163	82	,	,	PUNCT
admet-2582	163	83	bone	bone	NOUN
admet-2582	163	84	marrow	marrow	NOUN
admet-2582	163	85	,	,	PUNCT
admet-2582	163	86	kidney	kidney	NOUN
admet-2582	163	87	,	,	PUNCT
admet-2582	163	88	skin	skin	NOUN
admet-2582	163	89	,	,	PUNCT
admet-2582	163	90	bladder	bladder	NOUN
admet-2582	163	91	,	,	PUNCT
admet-2582	163	92	submandibular	submandibular	ADJ
admet-2582	163	93	gland	gland	NOUN
admet-2582	163	94	,	,	PUNCT
admet-2582	163	95	spleen	spleen	NOUN
admet-2582	163	96	,	,	PUNCT
admet-2582	163	97	testis	testis	NOUN
admet-2582	163	98	,	,	PUNCT
admet-2582	163	99	lymph	lymph	NOUN
admet-2582	163	100	nodes	node	NOUN
admet-2582	163	101	,	,	PUNCT
admet-2582	163	102	intestinal	intestinal	ADJ
admet-2582	163	103	wall	wall	NOUN
admet-2582	163	104	,	,	PUNCT
admet-2582	163	105	epididymis	epididymis	NOUN
admet-2582	163	106	,	,	PUNCT
admet-2582	163	107	heart	heart	NOUN
admet-2582	163	108	,	,	PUNCT
admet-2582	163	109	pancreas	pancrea	NOUN
admet-2582	163	110	,	,	PUNCT
admet-2582	163	111	gastric	gastric	ADJ
admet-2582	163	112	wall	wall	NOUN
admet-2582	163	113	,	,	PUNCT
admet-2582	163	114	body	body	NOUN
admet-2582	163	115	fat	fat	NOUN
admet-2582	163	116	,	,	PUNCT
admet-2582	163	117	bone	bone	NOUN
admet-2582	163	118	,	,	PUNCT
admet-2582	163	119	eye	eye	NOUN
admet-2582	163	120	,	,	PUNCT
admet-2582	163	121	skeletal	skeletal	ADJ
admet-2582	163	122	muscle	muscle	NOUN
admet-2582	163	123	,	,	PUNCT
admet-2582	163	124	and	and	CCONJ
admet-2582	163	125	brain	brain	NOUN
admet-2582	163	126	(	(	PUNCT
admet-2582	163	127	figure	figure	NOUN
admet-2582	163	128	4c	4c	NOUN
admet-2582	163	129	)	)	PUNCT
admet-2582	163	130	.	.	PUNCT
admet-2582	164	1	the	the	DET
admet-2582	164	2	acn	acn	PROPN
admet-2582	164	3	-	-	PUNCT
admet-2582	164	4	extract	extract	NOUN
admet-2582	164	5	fraction	fraction	NOUN
admet-2582	164	6	radioactivity	radioactivity	NOUN
admet-2582	164	7	auc0	auc0	PROPN
admet-2582	164	8	-	-	PUNCT
admet-2582	164	9	t	t	PROPN
admet-2582	164	10	from	from	ADP
admet-2582	164	11	high	high	ADJ
admet-2582	164	12	to	to	ADP
admet-2582	164	13	low	low	ADJ
admet-2582	164	14	tissues	tissue	NOUN
admet-2582	164	15	/	/	SYM
admet-2582	164	16	fluids	fluid	NOUN
admet-2582	164	17	were	be	AUX
admet-2582	164	18	blood	blood	NOUN
admet-2582	164	19	,	,	PUNCT
admet-2582	164	20	the	the	DET
admet-2582	164	21	tumours	tumour	NOUN
admet-2582	164	22	,	,	PUNCT
admet-2582	164	23	liver	liver	NOUN
admet-2582	164	24	,	,	PUNCT
admet-2582	164	25	lung	lung	NOUN
admet-2582	164	26	,	,	PUNCT
admet-2582	164	27	uterus	uterus	NOUN
admet-2582	164	28	,	,	PUNCT
admet-2582	164	29	adrenal	adrenal	ADJ
admet-2582	164	30	gland	gland	NOUN
admet-2582	164	31	,	,	PUNCT
admet-2582	164	32	ovary	ovary	ADJ
admet-2582	164	33	,	,	PUNCT
admet-2582	164	34	bone	bone	NOUN
admet-2582	164	35	marrow	marrow	NOUN
admet-2582	164	36	,	,	PUNCT
admet-2582	164	37	kidney	kidney	NOUN
admet-2582	164	38	,	,	PUNCT
admet-2582	164	39	skin	skin	NOUN
admet-2582	164	40	,	,	PUNCT
admet-2582	164	41	bladder	bladder	NOUN
admet-2582	164	42	,	,	PUNCT
admet-2582	164	43	submandibular	submandibular	ADJ
admet-2582	164	44	gland	gland	NOUN
admet-2582	164	45	,	,	PUNCT
admet-2582	164	46	spleen	spleen	NOUN
admet-2582	164	47	,	,	PUNCT
admet-2582	164	48	testis	testis	NOUN
admet-2582	164	49	,	,	PUNCT
admet-2582	164	50	lymph	lymph	NOUN
admet-2582	164	51	nodes	node	NOUN
admet-2582	164	52	,	,	PUNCT
admet-2582	164	53	intestinal	intestinal	ADJ
admet-2582	164	54	wall	wall	NOUN
admet-2582	164	55	,	,	PUNCT
admet-2582	164	56	epididymis	epididymis	NOUN
admet-2582	164	57	,	,	PUNCT
admet-2582	164	58	heart	heart	NOUN
admet-2582	164	59	,	,	PUNCT
admet-2582	164	60	pancreas	pancrea	NOUN
admet-2582	164	61	,	,	PUNCT
admet-2582	164	62	gastric	gastric	ADJ
admet-2582	164	63	wall	wall	NOUN
admet-2582	164	64	,	,	PUNCT
admet-2582	164	65	body	body	NOUN
admet-2582	164	66	fat	fat	NOUN
admet-2582	164	67	,	,	PUNCT
admet-2582	164	68	bone	bone	NOUN
admet-2582	164	69	,	,	PUNCT
admet-2582	164	70	eye	eye	NOUN
admet-2582	164	71	,	,	PUNCT
admet-2582	164	72	skeletal	skeletal	ADJ
admet-2582	164	73	muscle	muscle	NOUN
admet-2582	164	74	,	,	PUNCT
admet-2582	164	75	and	and	CCONJ
admet-2582	164	76	brain	brain	NOUN
admet-2582	164	77	(	(	PUNCT
admet-2582	164	78	figure	figure	NOUN
admet-2582	164	79	4c	4c	NOUN
admet-2582	164	80	)	)	PUNCT
admet-2582	164	81	.	.	PUNCT
admet-2582	165	1	the	the	DET
admet-2582	165	2	acn	acn	PROPN
admet-2582	165	3	-	-	PUNCT
admet-2582	165	4	extract	extract	NOUN
admet-2582	165	5	fraction	fraction	NOUN
admet-2582	165	6	auc0	auc0	PROPN
admet-2582	165	7	-	-	PUNCT
admet-2582	165	8	t	t	PROPN
admet-2582	165	9	results	result	NOUN
admet-2582	165	10	showed	show	VERB
admet-2582	165	11	the	the	DET
admet-2582	165	12	auc0	auc0	NOUN
admet-2582	165	13	-	-	PUNCT
admet-2582	165	14	t	t	NOUN
admet-2582	165	15	ratio	ratio	NOUN
admet-2582	165	16	of	of	ADP
admet-2582	165	17	tissues	tissue	NOUN
admet-2582	165	18	and	and	CCONJ
admet-2582	165	19	plasma	plasma	NOUN
admet-2582	165	20	extractable	extractable	ADJ
admet-2582	165	21	fraction	fraction	NOUN
admet-2582	165	22	in	in	ADP
admet-2582	165	23	tumour	tumour	NOUN
admet-2582	165	24	,	,	PUNCT
admet-2582	165	25	spleen	spleen	NOUN
admet-2582	165	26	,	,	PUNCT
admet-2582	165	27	liver	liver	NOUN
admet-2582	165	28	,	,	PUNCT
admet-2582	165	29	and	and	CCONJ
admet-2582	165	30	kidney	kidney	NOUN
admet-2582	165	31	from	from	ADP
admet-2582	165	32	high	high	ADJ
admet-2582	165	33	to	to	ADP
admet-2582	165	34	low	low	ADJ
admet-2582	165	35	,	,	PUNCT
admet-2582	165	36	which	which	PRON
admet-2582	165	37	were	be	AUX
admet-2582	165	38	18.57	18.57	NUM
admet-2582	165	39	,	,	PUNCT
admet-2582	165	40	2.04	2.04	NUM
admet-2582	165	41	,	,	PUNCT
admet-2582	165	42	1.81	1.81	NUM
admet-2582	165	43	,	,	PUNCT
admet-2582	165	44	and	and	CCONJ
admet-2582	165	45	1.11	1.11	NUM
admet-2582	165	46	times	time	NOUN
admet-2582	165	47	plasma	plasma	NOUN
admet-2582	165	48	,	,	PUNCT
admet-2582	165	49	respectively	respectively	ADV
admet-2582	165	50	(	(	PUNCT
admet-2582	165	51	figure	figure	NOUN
admet-2582	165	52	4c	4c	NOUN
admet-2582	165	53	)	)	PUNCT
admet-2582	165	54	.	.	PUNCT
admet-2582	166	1	the	the	DET
admet-2582	166	2	results	result	NOUN
admet-2582	166	3	suggested	suggest	VERB
admet-2582	166	4	that	that	SCONJ
admet-2582	166	5	mmae	mmae	NOUN
admet-2582	166	6	and	and	CCONJ
admet-2582	166	7	its	its	PRON
admet-2582	166	8	metabolites	metabolite	NOUN
admet-2582	166	9	were	be	AUX
admet-2582	166	10	mainly	mainly	ADV
admet-2582	166	11	distributed	distribute	VERB
admet-2582	166	12	in	in	ADP
admet-2582	166	13	tumours	tumours	PROPN
admet-2582	166	14	,	,	PUNCT
admet-2582	166	15	spleen	spleen	NOUN
admet-2582	166	16	,	,	PUNCT
admet-2582	166	17	liver	liver	NOUN
admet-2582	166	18	,	,	PUNCT
admet-2582	166	19	and	and	CCONJ
admet-2582	166	20	kidney	kidney	NOUN
admet-2582	166	21	.	.	PUNCT
admet-2582	167	1	judged	judge	VERB
admet-2582	167	2	from	from	ADP
admet-2582	167	3	the	the	DET
admet-2582	167	4	tissue	tissue	NOUN
admet-2582	167	5	distribution	distribution	NOUN
admet-2582	167	6	study	study	NOUN
admet-2582	167	7	of	of	ADP
admet-2582	167	8	[	[	PUNCT
admet-2582	167	9	3h	3h	NUM
admet-2582	167	10	-	-	PUNCT
admet-2582	167	11	mmae]-rc48	mmae]-rc48	NOUN
admet-2582	167	12	-	-	PUNCT
admet-2582	167	13	adc	adc	NOUN
admet-2582	167	14	,	,	PUNCT
admet-2582	167	15	the	the	DET
admet-2582	167	16	exposure	exposure	NOUN
admet-2582	167	17	of	of	ADP
admet-2582	167	18	3h	3h	NUM
admet-2582	167	19	-	-	PUNCT
admet-2582	167	20	mmae	mmae	NOUN
admet-2582	167	21	in	in	ADP
admet-2582	167	22	the	the	DET
admet-2582	167	23	tumour	tumour	NOUN
admet-2582	167	24	was	be	AUX
admet-2582	167	25	the	the	DET
admet-2582	167	26	highest	high	ADJ
admet-2582	167	27	and	and	CCONJ
admet-2582	167	28	much	much	ADV
admet-2582	167	29	higher	high	ADJ
admet-2582	167	30	than	than	ADP
admet-2582	167	31	the	the	DET
admet-2582	167	32	plasma	plasma	NOUN
admet-2582	167	33	and	and	CCONJ
admet-2582	167	34	several	several	ADJ
admet-2582	167	35	other	other	ADJ
admet-2582	167	36	tissues	tissue	NOUN
admet-2582	167	37	and	and	CCONJ
admet-2582	167	38	exposure	exposure	NOUN
admet-2582	167	39	was	be	AUX
admet-2582	167	40	more	more	ADV
admet-2582	167	41	persistent	persistent	ADJ
admet-2582	167	42	.	.	PUNCT
admet-2582	168	1	the	the	DET
admet-2582	168	2	results	result	NOUN
admet-2582	168	3	suggested	suggest	VERB
admet-2582	168	4	that	that	SCONJ
admet-2582	168	5	although	although	SCONJ
admet-2582	168	6	rc48	rc48	PROPN
admet-2582	168	7	-	-	PUNCT
admet-2582	168	8	adc	adc	PROPN
admet-2582	168	9	is	be	AUX
admet-2582	168	10	highly	highly	ADV
admet-2582	168	11	exposed	expose	VERB
admet-2582	168	12	in	in	ADP
admet-2582	168	13	plasma	plasma	NOUN
admet-2582	168	14	,	,	PUNCT
admet-2582	168	15	most	most	ADJ
admet-2582	168	16	of	of	ADP
admet-2582	168	17	the	the	DET
admet-2582	168	18	time	time	NOUN
admet-2582	168	19	,	,	PUNCT
admet-2582	168	20	it	it	PRON
admet-2582	168	21	exists	exist	VERB
admet-2582	168	22	in	in	ADP
admet-2582	168	23	the	the	DET
admet-2582	168	24	form	form	NOUN
admet-2582	168	25	of	of	ADP
admet-2582	168	26	rc48	rc48	PROPN
admet-2582	168	27	-	-	PUNCT
admet-2582	168	28	adc	adc	PROPN
admet-2582	168	29	,	,	PUNCT
admet-2582	168	30	while	while	SCONJ
admet-2582	168	31	small	small	ADJ
admet-2582	168	32	molecular	molecular	ADJ
admet-2582	168	33	payloads	payload	NOUN
admet-2582	168	34	are	be	AUX
admet-2582	168	35	rarely	rarely	ADV
admet-2582	168	36	released	release	VERB
admet-2582	168	37	in	in	ADP
admet-2582	168	38	plasma	plasma	NOUN
admet-2582	168	39	,	,	PUNCT
admet-2582	168	40	the	the	DET
admet-2582	168	41	vast	vast	ADJ
admet-2582	168	42	majority	majority	NOUN
admet-2582	168	43	of	of	ADP
admet-2582	168	44	3h	3h	NUM
admet-2582	168	45	-	-	PUNCT
admet-2582	168	46	mmae	mmae	NOUN
admet-2582	168	47	was	be	AUX
admet-2582	168	48	released	release	VERB
admet-2582	168	49	by	by	ADP
admet-2582	168	50	rc48	rc48	PROPN
admet-2582	168	51	-	-	PUNCT
admet-2582	168	52	adc	adc	PROPN
admet-2582	168	53	in	in	ADP
admet-2582	168	54	the	the	DET
admet-2582	168	55	tumour	tumour	NOUN
admet-2582	168	56	location	location	NOUN
admet-2582	168	57	.	.	PUNCT
admet-2582	169	1	these	these	PRON
admet-2582	169	2	above	above	ADP
admet-2582	169	3	outcomes	outcome	NOUN
admet-2582	169	4	indicated	indicate	VERB
admet-2582	169	5	that	that	SCONJ
admet-2582	169	6	mmae	mmae	NOUN
admet-2582	169	7	and	and	CCONJ
admet-2582	169	8	its	its	PRON
admet-2582	169	9	metabolites	metabolite	NOUN
admet-2582	169	10	were	be	AUX
admet-2582	169	11	mainly	mainly	ADV
admet-2582	169	12	distributed	distribute	VERB
admet-2582	169	13	in	in	ADP
admet-2582	169	14	tumours	tumours	PROPN
admet-2582	169	15	,	,	PUNCT
admet-2582	169	16	spleen	spleen	NOUN
admet-2582	169	17	,	,	PUNCT
admet-2582	169	18	liver	liver	NOUN
admet-2582	169	19	,	,	PUNCT
admet-2582	169	20	and	and	CCONJ
admet-2582	169	21	kidney	kidney	NOUN
admet-2582	169	22	,	,	PUNCT
admet-2582	169	23	and	and	CCONJ
admet-2582	169	24	rc48	rc48	PROPN
admet-2582	169	25	-	-	PUNCT
admet-2582	169	26	adc	adc	PROPN
admet-2582	169	27	showed	show	VERB
admet-2582	169	28	excellent	excellent	ADJ
admet-2582	169	29	performance	performance	NOUN
admet-2582	169	30	of	of	ADP
admet-2582	169	31	tumour	tumour	NOUN
admet-2582	169	32	targeting	targeting	NOUN
admet-2582	169	33	,	,	PUNCT
admet-2582	169	34	but	but	CCONJ
admet-2582	169	35	the	the	DET
admet-2582	169	36	toxicity	toxicity	NOUN
admet-2582	169	37	of	of	ADP
admet-2582	169	38	the	the	DET
admet-2582	169	39	spleen	spleen	NOUN
admet-2582	169	40	,	,	PUNCT
admet-2582	169	41	liver	liver	NOUN
admet-2582	169	42	,	,	PUNCT
admet-2582	169	43	and	and	CCONJ
admet-2582	169	44	kidney	kidney	NOUN
admet-2582	169	45	also	also	ADV
admet-2582	169	46	should	should	AUX
admet-2582	169	47	be	be	AUX
admet-2582	169	48	paid	pay	VERB
admet-2582	169	49	attention	attention	NOUN
admet-2582	169	50	to	to	ADP
admet-2582	169	51	.	.	PUNCT
admet-2582	170	1	excretion	excretion	VERB
admet-2582	170	2	the	the	DET
admet-2582	170	3	excretion	excretion	NOUN
admet-2582	170	4	of	of	ADP
admet-2582	170	5	the	the	DET
admet-2582	170	6	rc48	rc48	PROPN
admet-2582	170	7	-	-	PUNCT
admet-2582	170	8	adc	adc	PROPN
admet-2582	170	9	was	be	AUX
admet-2582	170	10	relatively	relatively	ADV
admet-2582	170	11	slow	slow	ADJ
admet-2582	170	12	and	and	CCONJ
admet-2582	170	13	primarily	primarily	ADV
admet-2582	170	14	in	in	ADP
admet-2582	170	15	the	the	DET
admet-2582	170	16	urine	urine	NOUN
admet-2582	170	17	(	(	PUNCT
admet-2582	170	18	figure	figure	NOUN
admet-2582	170	19	5a	5a	NUM
admet-2582	170	20	)	)	PUNCT
admet-2582	170	21	.	.	PUNCT
admet-2582	171	1	a	a	DET
admet-2582	171	2	b	b	NOUN
admet-2582	171	3	time	time	NOUN
admet-2582	171	4	,	,	PUNCT
admet-2582	171	5	h	h	NOUN
admet-2582	171	6	time	time	NOUN
admet-2582	171	7	,	,	PUNCT
admet-2582	171	8	h	h	NOUN
admet-2582	171	9	c	c	NOUN
admet-2582	171	10	d	d	PROPN
admet-2582	171	11	time	time	NOUN
admet-2582	171	12	,	,	PUNCT
admet-2582	171	13	h	h	NOUN
admet-2582	171	14	time	time	NOUN
admet-2582	171	15	,	,	PUNCT
admet-2582	171	16	h	h	NOUN
admet-2582	171	17	figure	figure	NOUN
admet-2582	171	18	5	5	NUM
admet-2582	171	19	.	.	PUNCT
admet-2582	172	1	excretion	excretion	NOUN
admet-2582	172	2	of	of	ADP
admet-2582	172	3	[	[	X
admet-2582	172	4	125i]–rc48	125i]–rc48	NUM
admet-2582	172	5	-	-	PUNCT
admet-2582	172	6	adc	adc	NOUN
admet-2582	172	7	and	and	CCONJ
admet-2582	172	8	[	[	X
admet-2582	172	9	3h	3h	NUM
admet-2582	172	10	-	-	PUNCT
admet-2582	172	11	mmae	mmae	NOUN
admet-2582	172	12	]	]	PUNCT
admet-2582	172	13	-rc48	-rc48	PROPN
admet-2582	172	14	-	-	PUNCT
admet-2582	172	15	adc	adc	PROPN
admet-2582	172	16	in	in	ADP
admet-2582	172	17	urine	urine	NOUN
admet-2582	172	18	,	,	PUNCT
admet-2582	172	19	faeces	faece	NOUN
admet-2582	172	20	,	,	PUNCT
admet-2582	172	21	and	and	CCONJ
admet-2582	172	22	bile	bile	NOUN
admet-2582	172	23	.	.	PUNCT
admet-2582	173	1	(	(	PUNCT
admet-2582	173	2	a	a	X
admet-2582	173	3	)	)	PUNCT
admet-2582	173	4	urine	urine	NOUN
admet-2582	173	5	and	and	CCONJ
admet-2582	173	6	faeces	faece	NOUN
admet-2582	173	7	excretion	excretion	NOUN
admet-2582	173	8	of	of	ADP
admet-2582	173	9	[	[	X
admet-2582	173	10	125i]–rc48	125i]–rc48	NUM
admet-2582	173	11	-	-	PUNCT
admet-2582	173	12	adc	adc	NOUN
admet-2582	173	13	in	in	ADP
admet-2582	173	14	tumour	tumour	NOUN
admet-2582	173	15	-	-	PUNCT
admet-2582	173	16	bearing	bear	VERB
admet-2582	173	17	nude	nude	ADJ
admet-2582	173	18	mice	mouse	NOUN
admet-2582	173	19	following	follow	VERB
admet-2582	173	20	a	a	DET
admet-2582	173	21	single	single	ADJ
admet-2582	173	22	bolus	bolus	ADJ
admet-2582	173	23	i.v	i.v	PROPN
admet-2582	173	24	.	.	PUNCT
admet-2582	173	25	administration	administration	NOUN
admet-2582	173	26	of	of	ADP
admet-2582	173	27	12	12	NUM
admet-2582	173	28	mg	mg	PROPN
admet-2582	173	29	/	/	SYM
admet-2582	173	30	kg	kg	PROPN
admet-2582	173	31	(	(	PUNCT
admet-2582	173	32	mean	mean	PROPN
admet-2582	173	33	±	±	NUM
admet-2582	173	34	sd	sd	NOUN
admet-2582	173	35	,	,	PUNCT
admet-2582	173	36	n	n	NOUN
admet-2582	173	37	=	=	NUM
admet-2582	173	38	12	12	NUM
admet-2582	173	39	per	per	ADP
admet-2582	173	40	time	time	NOUN
admet-2582	173	41	point	point	NOUN
admet-2582	173	42	per	per	ADP
admet-2582	173	43	group	group	NOUN
admet-2582	173	44	)	)	PUNCT
admet-2582	173	45	;	;	PUNCT
admet-2582	173	46	(	(	PUNCT
admet-2582	173	47	b	b	X
admet-2582	173	48	)	)	PUNCT
admet-2582	173	49	bile	bile	NOUN
admet-2582	173	50	excretion	excretion	NOUN
admet-2582	173	51	of	of	ADP
admet-2582	173	52	[	[	X
admet-2582	173	53	125i]–rc48	125i]–rc48	NUM
admet-2582	173	54	-	-	PUNCT
admet-2582	173	55	adc	adc	NOUN
admet-2582	173	56	in	in	ADP
admet-2582	173	57	the	the	DET
admet-2582	173	58	rats	rat	NOUN
admet-2582	173	59	following	follow	VERB
admet-2582	173	60	a	a	DET
admet-2582	173	61	single	single	ADJ
admet-2582	173	62	bolus	bolus	ADJ
admet-2582	173	63	i.v	i.v	PROPN
admet-2582	173	64	.	.	PUNCT
admet-2582	173	65	administration	administration	NOUN
admet-2582	173	66	of	of	ADP
admet-2582	173	67	8	8	NUM
admet-2582	173	68	mg	mg	NUM
admet-2582	173	69	/	/	SYM
admet-2582	173	70	kg	kg	PROPN
admet-2582	173	71	(	(	PUNCT
admet-2582	173	72	mean	mean	PROPN
admet-2582	173	73	±	±	NUM
admet-2582	173	74	sd	sd	NOUN
admet-2582	173	75	,	,	PUNCT
admet-2582	173	76	n	n	NOUN
admet-2582	173	77	=	=	NUM
admet-2582	173	78	6	6	NUM
admet-2582	173	79	per	per	ADP
admet-2582	173	80	time	time	NOUN
admet-2582	173	81	point	point	NOUN
admet-2582	173	82	per	per	ADP
admet-2582	173	83	group	group	NOUN
admet-2582	173	84	)	)	PUNCT
admet-2582	173	85	;	;	PUNCT
admet-2582	173	86	(	(	PUNCT
admet-2582	173	87	c	c	X
admet-2582	173	88	)	)	PUNCT
admet-2582	173	89	urine	urine	NOUN
admet-2582	173	90	and	and	CCONJ
admet-2582	173	91	faeces	faece	NOUN
admet-2582	173	92	excretion	excretion	NOUN
admet-2582	173	93	of	of	ADP
admet-2582	173	94	[	[	PUNCT
admet-2582	173	95	3h	3h	NUM
admet-2582	173	96	-	-	PUNCT
admet-2582	173	97	mmae	mmae	NOUN
admet-2582	173	98	]	]	PUNCT
admet-2582	173	99	-rc48	-rc48	PROPN
admet-2582	173	100	-	-	PUNCT
admet-2582	173	101	adc	adc	PROPN
admet-2582	173	102	in	in	ADP
admet-2582	173	103	the	the	DET
admet-2582	173	104	sd	sd	NOUN
admet-2582	173	105	rats	rat	NOUN
admet-2582	173	106	following	follow	VERB
admet-2582	173	107	a	a	DET
admet-2582	173	108	single	single	ADJ
admet-2582	173	109	bolus	bolus	ADJ
admet-2582	173	110	i.v	i.v	PROPN
admet-2582	173	111	.	.	PUNCT
admet-2582	173	112	administration	administration	NOUN
admet-2582	173	113	of	of	ADP
admet-2582	173	114	8	8	NUM
admet-2582	173	115	mg	mg	NUM
admet-2582	173	116	/	/	SYM
admet-2582	173	117	kg	kg	PROPN
admet-2582	173	118	(	(	PUNCT
admet-2582	173	119	mean	mean	PROPN
admet-2582	173	120	±	±	NUM
admet-2582	173	121	sd	sd	NOUN
admet-2582	173	122	,	,	PUNCT
admet-2582	173	123	n	n	NOUN
admet-2582	173	124	=	=	NUM
admet-2582	173	125	6	6	NUM
admet-2582	173	126	per	per	ADP
admet-2582	173	127	time	time	NOUN
admet-2582	173	128	point	point	NOUN
admet-2582	173	129	per	per	ADP
admet-2582	173	130	group	group	NOUN
admet-2582	173	131	,	,	PUNCT
admet-2582	173	132	)	)	PUNCT
admet-2582	173	133	;	;	PUNCT
admet-2582	173	134	(	(	PUNCT
admet-2582	173	135	d	d	X
admet-2582	173	136	)	)	PUNCT
admet-2582	173	137	bile	bile	NOUN
admet-2582	173	138	excretion	excretion	NOUN
admet-2582	173	139	of	of	ADP
admet-2582	173	140	[	[	PUNCT
admet-2582	173	141	3h	3h	NUM
admet-2582	173	142	-	-	PUNCT
admet-2582	173	143	mmae	mmae	NOUN
admet-2582	173	144	]	]	PUNCT
admet-2582	173	145	-rc48	-rc48	PROPN
admet-2582	173	146	-	-	PUNCT
admet-2582	173	147	adc	adc	PROPN
admet-2582	173	148	in	in	ADP
admet-2582	173	149	the	the	DET
admet-2582	173	150	sd	sd	NOUN
admet-2582	173	151	rats	rat	NOUN
admet-2582	173	152	following	follow	VERB
admet-2582	173	153	a	a	DET
admet-2582	173	154	single	single	ADJ
admet-2582	173	155	bolus	bolus	ADJ
admet-2582	173	156	i.v	i.v	PROPN
admet-2582	173	157	.	.	PUNCT
admet-2582	173	158	administration	administration	NOUN
admet-2582	173	159	of	of	ADP
admet-2582	173	160	8	8	NUM
admet-2582	173	161	mg	mg	NUM
admet-2582	173	162	/	/	SYM
admet-2582	173	163	kg	kg	PROPN
admet-2582	173	164	(	(	PUNCT
admet-2582	173	165	mean	mean	PROPN
admet-2582	173	166	±	±	NUM
admet-2582	173	167	sd	sd	NOUN
admet-2582	173	168	,	,	PUNCT
admet-2582	173	169	n	n	NOUN
admet-2582	173	170	=	=	NUM
admet-2582	173	171	6	6	NUM
admet-2582	173	172	per	per	ADP
admet-2582	173	173	time	time	NOUN
admet-2582	173	174	point	point	NOUN
admet-2582	173	175	per	per	ADP
admet-2582	173	176	group	group	NOUN
admet-2582	173	177	)	)	PUNCT
admet-2582	174	1	c	c	PROPN
admet-2582	174	2	u	u	NOUN
admet-2582	174	3	m	m	VERB
admet-2582	174	4	u	u	VERB
admet-2582	174	5	la	la	X
admet-2582	174	6	ti	ti	X
admet-2582	174	7	ve	ve	PROPN
admet-2582	174	8	e	e	NOUN
admet-2582	174	9	xt	xt	PROPN
admet-2582	175	1	ra	ra	PROPN
admet-2582	176	1	ct	ct	PROPN
admet-2582	176	2	io	io	PROPN
admet-2582	176	3	n	n	PROPN
admet-2582	176	4	,	,	PUNCT
admet-2582	176	5	%	%	INTJ
admet-2582	176	6	c	c	X
admet-2582	176	7	u	u	VERB
admet-2582	176	8	m	m	VERB
admet-2582	176	9	u	u	VERB
admet-2582	176	10	la	la	X
admet-2582	176	11	ti	ti	X
admet-2582	176	12	ve	ve	PROPN
admet-2582	176	13	e	e	NOUN
admet-2582	176	14	xt	xt	PROPN
admet-2582	176	15	ra	ra	PROPN
admet-2582	176	16	ct	ct	PROPN
admet-2582	176	17	io	io	PROPN
admet-2582	176	18	n	n	PROPN
admet-2582	176	19	,	,	PUNCT
admet-2582	176	20	%	%	INTJ
admet-2582	176	21	c	c	X
admet-2582	176	22	u	u	VERB
admet-2582	176	23	m	m	VERB
admet-2582	176	24	u	u	VERB
admet-2582	176	25	la	la	X
admet-2582	176	26	ti	ti	X
admet-2582	176	27	ve	ve	PROPN
admet-2582	176	28	e	e	NOUN
admet-2582	176	29	xt	xt	PROPN
admet-2582	176	30	ra	ra	PROPN
admet-2582	176	31	ct	ct	PROPN
admet-2582	176	32	io	io	PROPN
admet-2582	176	33	n	n	PROPN
admet-2582	176	34	,	,	PUNCT
admet-2582	176	35	%	%	INTJ
admet-2582	176	36	c	c	X
admet-2582	176	37	u	u	VERB
admet-2582	176	38	m	m	VERB
admet-2582	176	39	u	u	VERB
admet-2582	176	40	la	la	X
admet-2582	176	41	ti	ti	X
admet-2582	176	42	ve	ve	PROPN
admet-2582	176	43	e	e	NOUN
admet-2582	176	44	xt	xt	PROPN
admet-2582	176	45	ra	ra	PROPN
admet-2582	176	46	ct	ct	PROPN
admet-2582	176	47	io	io	PROPN
admet-2582	177	1	n	n	PROPN
admet-2582	177	2	,	,	PUNCT
admet-2582	177	3	%	%	INTJ
admet-2582	177	4	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	177	5	m.	m.	NOUN
admet-2582	177	6	das	das	PROPN
admet-2582	178	1	et	et	PROPN
admet-2582	178	2	al	al	PROPN
admet-2582	178	3	.	.	PROPN
admet-2582	178	4	admet	admet	PROPN
admet-2582	178	5	&	&	CCONJ
admet-2582	178	6	dmpk	dmpk	PROPN
admet-2582	178	7	13(2	13(2	PROPN
admet-2582	178	8	)	)	PUNCT
admet-2582	178	9	(	(	PUNCT
admet-2582	178	10	2025	2025	NUM
admet-2582	178	11	)	)	PUNCT
admet-2582	178	12	2582	2582	NUM
admet-2582	178	13	10	10	NUM
admet-2582	178	14	after	after	ADP
admet-2582	178	15	336	336	NUM
admet-2582	178	16	h	h	NOUN
admet-2582	178	17	,	,	PUNCT
admet-2582	178	18	the	the	DET
admet-2582	178	19	excretion	excretion	NOUN
admet-2582	178	20	in	in	ADP
admet-2582	178	21	the	the	DET
admet-2582	178	22	urine	urine	NOUN
admet-2582	178	23	and	and	CCONJ
admet-2582	178	24	the	the	DET
admet-2582	178	25	faeces	faece	NOUN
admet-2582	178	26	accounted	account	VERB
admet-2582	178	27	for	for	ADP
admet-2582	178	28	75.64±2.80	75.64±2.80	NUM
admet-2582	178	29	and	and	CCONJ
admet-2582	178	30	0.90±0.13	0.90±0.13	NUM
admet-2582	178	31	%	%	NOUN
admet-2582	178	32	of	of	ADP
admet-2582	178	33	the	the	DET
admet-2582	178	34	administered	administer	VERB
admet-2582	178	35	radioactivity	radioactivity	NOUN
admet-2582	178	36	,	,	PUNCT
admet-2582	178	37	respectively	respectively	ADV
admet-2582	178	38	.	.	PUNCT
admet-2582	179	1	the	the	DET
admet-2582	179	2	shplc	shplc	PROPN
admet-2582	179	3	analysis	analysis	NOUN
admet-2582	179	4	showed	show	VERB
admet-2582	179	5	that	that	SCONJ
admet-2582	179	6	only	only	ADV
admet-2582	179	7	small	small	ADJ
admet-2582	179	8	-	-	PUNCT
admet-2582	179	9	molecule	molecule	NOUN
admet-2582	179	10	degradation	degradation	NOUN
admet-2582	179	11	products	product	NOUN
admet-2582	179	12	were	be	AUX
admet-2582	179	13	present	present	ADJ
admet-2582	179	14	in	in	ADP
admet-2582	179	15	the	the	DET
admet-2582	179	16	urine	urine	NOUN
admet-2582	179	17	,	,	PUNCT
admet-2582	179	18	not	not	PART
admet-2582	179	19	the	the	DET
admet-2582	179	20	original	original	ADJ
admet-2582	179	21	form	form	NOUN
admet-2582	179	22	of	of	ADP
admet-2582	179	23	the	the	DET
admet-2582	179	24	test	test	NOUN
admet-2582	179	25	article	article	NOUN
admet-2582	179	26	.	.	PUNCT
admet-2582	180	1	the	the	DET
admet-2582	180	2	24	24	NUM
admet-2582	180	3	-	-	PUNCT
admet-2582	180	4	hour	hour	NOUN
admet-2582	180	5	cumulative	cumulative	ADJ
admet-2582	180	6	excretion	excretion	NOUN
admet-2582	180	7	in	in	ADP
admet-2582	180	8	the	the	DET
admet-2582	180	9	bile	bile	NOUN
admet-2582	180	10	accounted	account	VERB
admet-2582	180	11	for	for	ADP
admet-2582	180	12	0.17±0.06	0.17±0.06	PROPN
admet-2582	180	13	%	%	NOUN
admet-2582	180	14	of	of	ADP
admet-2582	180	15	the	the	DET
admet-2582	180	16	administered	administer	VERB
admet-2582	180	17	radioactivity	radioactivity	NOUN
admet-2582	180	18	(	(	PUNCT
admet-2582	180	19	figure	figure	NOUN
admet-2582	180	20	5b	5b	NUM
admet-2582	180	21	)	)	PUNCT
admet-2582	180	22	.	.	PUNCT
admet-2582	181	1	the	the	DET
admet-2582	181	2	excretion	excretion	NOUN
admet-2582	181	3	of	of	ADP
admet-2582	181	4	rc48adc	rc48adc	PROPN
admet-2582	181	5	radioactivity	radioactivity	NOUN
admet-2582	181	6	was	be	AUX
admet-2582	181	7	relatively	relatively	ADV
admet-2582	181	8	slow	slow	ADJ
admet-2582	181	9	and	and	CCONJ
admet-2582	181	10	primarily	primarily	ADV
admet-2582	181	11	in	in	ADP
admet-2582	181	12	the	the	DET
admet-2582	181	13	urine	urine	NOUN
admet-2582	181	14	,	,	PUNCT
admet-2582	181	15	meanwhile	meanwhile	ADV
admet-2582	181	16	,	,	PUNCT
admet-2582	181	17	the	the	DET
admet-2582	181	18	faeces	faece	NOUN
admet-2582	181	19	and	and	CCONJ
admet-2582	181	20	bile	bile	NOUN
admet-2582	181	21	were	be	AUX
admet-2582	181	22	bare	bare	ADJ
admet-2582	181	23	of	of	ADP
admet-2582	181	24	rc48	rc48	PROPN
admet-2582	181	25	-	-	PUNCT
admet-2582	181	26	adc	adc	PROPN
admet-2582	181	27	radioactivity	radioactivity	NOUN
admet-2582	181	28	.	.	PUNCT
admet-2582	182	1	these	these	DET
admet-2582	182	2	results	result	NOUN
admet-2582	182	3	are	be	AUX
admet-2582	182	4	consistent	consistent	ADJ
admet-2582	182	5	with	with	ADP
admet-2582	182	6	the	the	DET
admet-2582	182	7	findings	finding	NOUN
admet-2582	182	8	in	in	ADP
admet-2582	182	9	the	the	DET
admet-2582	182	10	tissue	tissue	NOUN
admet-2582	182	11	distribution	distribution	NOUN
admet-2582	182	12	study	study	NOUN
admet-2582	182	13	that	that	SCONJ
admet-2582	182	14	the	the	DET
admet-2582	182	15	radioactive	radioactive	ADJ
admet-2582	182	16	concentration	concentration	NOUN
admet-2582	182	17	of	of	ADP
admet-2582	182	18	rc48	rc48	PROPN
admet-2582	182	19	-	-	PUNCT
admet-2582	182	20	adc	adc	PROPN
admet-2582	182	21	in	in	ADP
admet-2582	182	22	the	the	DET
admet-2582	182	23	bladder	bladder	NOUN
admet-2582	182	24	and	and	CCONJ
admet-2582	182	25	kidneys	kidney	NOUN
admet-2582	182	26	is	be	AUX
admet-2582	182	27	much	much	ADV
admet-2582	182	28	higher	high	ADJ
admet-2582	182	29	than	than	ADP
admet-2582	182	30	in	in	ADP
admet-2582	182	31	the	the	DET
admet-2582	182	32	small	small	ADJ
admet-2582	182	33	intestine	intestine	NOUN
admet-2582	182	34	and	and	CCONJ
admet-2582	182	35	intestinal	intestinal	ADJ
admet-2582	182	36	contents	content	NOUN
admet-2582	182	37	.	.	PUNCT
admet-2582	183	1	furthermore	furthermore	ADV
admet-2582	183	2	,	,	PUNCT
admet-2582	183	3	the	the	DET
admet-2582	183	4	urine	urine	NOUN
admet-2582	183	5	and	and	CCONJ
admet-2582	183	6	faeces	faece	NOUN
admet-2582	183	7	excretion	excretion	NOUN
admet-2582	183	8	of	of	ADP
admet-2582	183	9	[	[	PUNCT
admet-2582	183	10	3h	3h	NUM
admet-2582	183	11	-	-	PUNCT
admet-2582	183	12	mmae]-rc48	mmae]-rc48	NOUN
admet-2582	183	13	-	-	PUNCT
admet-2582	183	14	adc	adc	NOUN
admet-2582	183	15	in	in	ADP
admet-2582	183	16	rats	rat	NOUN
admet-2582	183	17	was	be	AUX
admet-2582	183	18	shown	show	VERB
admet-2582	183	19	in	in	ADP
admet-2582	183	20	figure	figure	NOUN
admet-2582	183	21	5c	5c	NOUN
admet-2582	183	22	.	.	PUNCT
admet-2582	184	1	the	the	DET
admet-2582	184	2	total	total	ADJ
admet-2582	184	3	urine	urine	NOUN
admet-2582	184	4	and	and	CCONJ
admet-2582	184	5	faeces	faece	NOUN
admet-2582	184	6	excretion	excretion	NOUN
admet-2582	184	7	of	of	ADP
admet-2582	184	8	mmae	mmae	NOUN
admet-2582	184	9	accounted	account	VERB
admet-2582	184	10	for	for	ADP
admet-2582	184	11	9.17	9.17	NUM
admet-2582	184	12	and	and	CCONJ
admet-2582	184	13	74.69	74.69	NUM
admet-2582	184	14	%	%	NOUN
admet-2582	184	15	of	of	ADP
admet-2582	184	16	the	the	DET
admet-2582	184	17	total	total	ADJ
admet-2582	184	18	dosage	dosage	NOUN
admet-2582	184	19	,	,	PUNCT
admet-2582	184	20	respectively	respectively	ADV
admet-2582	184	21	.	.	PUNCT
admet-2582	185	1	excretion	excretion	NOUN
admet-2582	185	2	of	of	ADP
admet-2582	185	3	mmae	mmae	NOUN
admet-2582	185	4	mainly	mainly	ADV
admet-2582	185	5	occurred	occur	VERB
admet-2582	185	6	in	in	ADP
admet-2582	185	7	the	the	DET
admet-2582	185	8	first	first	ADJ
admet-2582	185	9	week	week	NOUN
admet-2582	185	10	,	,	PUNCT
admet-2582	185	11	accounting	account	VERB
admet-2582	185	12	for	for	ADP
admet-2582	185	13	77.11	77.11	NUM
admet-2582	185	14	%	%	NOUN
admet-2582	185	15	of	of	ADP
admet-2582	185	16	the	the	DET
admet-2582	185	17	drug	drug	NOUN
admet-2582	185	18	dosage	dosage	NOUN
admet-2582	185	19	.	.	PUNCT
admet-2582	186	1	the	the	DET
admet-2582	186	2	bile	bile	NOUN
admet-2582	186	3	secretion	secretion	NOUN
admet-2582	186	4	of	of	ADP
admet-2582	186	5	mmae	mmae	NOUN
admet-2582	186	6	in	in	ADP
admet-2582	186	7	bile	bile	NOUN
admet-2582	186	8	-	-	PUNCT
admet-2582	186	9	duct	duct	NOUN
admet-2582	186	10	-	-	PUNCT
admet-2582	186	11	cannulated	cannulated	ADJ
admet-2582	186	12	(	(	PUNCT
admet-2582	186	13	bdc	bdc	NOUN
admet-2582	186	14	)	)	PUNCT
admet-2582	186	15	rats	rat	NOUN
admet-2582	186	16	accounted	account	VERB
admet-2582	186	17	for	for	ADP
admet-2582	186	18	78.44	78.44	NUM
admet-2582	186	19	%	%	NOUN
admet-2582	186	20	of	of	ADP
admet-2582	186	21	the	the	DET
admet-2582	186	22	total	total	ADJ
admet-2582	186	23	0	0	NUM
admet-2582	186	24	-	-	SYM
admet-2582	186	25	72	72	NUM
admet-2582	186	26	h	h	NOUN
admet-2582	186	27	excretion	excretion	NOUN
admet-2582	186	28	,	,	PUNCT
admet-2582	186	29	suggesting	suggest	VERB
admet-2582	186	30	that	that	SCONJ
admet-2582	186	31	biliary	biliary	ADJ
admet-2582	186	32	faecal	faecal	ADJ
admet-2582	186	33	route	route	NOUN
admet-2582	186	34	excretion	excretion	NOUN
admet-2582	186	35	was	be	AUX
admet-2582	186	36	the	the	DET
admet-2582	186	37	main	main	ADJ
admet-2582	186	38	excretion	excretion	NOUN
admet-2582	186	39	route	route	NOUN
admet-2582	186	40	of	of	ADP
admet-2582	186	41	mmae	mmae	NOUN
admet-2582	186	42	(	(	PUNCT
admet-2582	186	43	figure	figure	NOUN
admet-2582	186	44	5c	5c	NOUN
admet-2582	186	45	,	,	PUNCT
admet-2582	186	46	d	d	NOUN
admet-2582	186	47	)	)	PUNCT
admet-2582	186	48	.	.	PUNCT
admet-2582	187	1	metabolite	metabolite	NOUN
admet-2582	187	2	because	because	SCONJ
admet-2582	187	3	large	large	ADJ
admet-2582	187	4	molecular	molecular	ADJ
admet-2582	187	5	proteins	protein	NOUN
admet-2582	187	6	could	could	AUX
admet-2582	187	7	not	not	PART
admet-2582	187	8	be	be	AUX
admet-2582	187	9	extracted	extract	VERB
admet-2582	187	10	by	by	ADP
admet-2582	187	11	organic	organic	ADJ
admet-2582	187	12	solvent	solvent	NOUN
admet-2582	187	13	and	and	CCONJ
admet-2582	187	14	remained	remain	VERB
admet-2582	187	15	in	in	ADP
admet-2582	187	16	the	the	DET
admet-2582	187	17	extraction	extraction	NOUN
admet-2582	187	18	residue	residue	NOUN
admet-2582	187	19	,	,	PUNCT
admet-2582	187	20	only	only	ADV
admet-2582	187	21	the	the	DET
admet-2582	187	22	payload	payload	NOUN
admet-2582	187	23	(	(	PUNCT
admet-2582	187	24	mmae	mmae	NOUN
admet-2582	187	25	)	)	PUNCT
admet-2582	187	26	of	of	ADP
admet-2582	187	27	rc48	rc48	PROPN
admet-2582	187	28	-	-	PUNCT
admet-2582	187	29	adc	adc	PROPN
admet-2582	187	30	and	and	CCONJ
admet-2582	187	31	its	its	PRON
admet-2582	187	32	metabolites	metabolite	NOUN
admet-2582	187	33	were	be	AUX
admet-2582	187	34	analysed	analyse	VERB
admet-2582	187	35	in	in	ADP
admet-2582	187	36	this	this	DET
admet-2582	187	37	study	study	NOUN
admet-2582	187	38	.	.	PUNCT
admet-2582	188	1	as	as	SCONJ
admet-2582	188	2	shown	show	VERB
admet-2582	188	3	in	in	ADP
admet-2582	188	4	table	table	NOUN
admet-2582	188	5	2	2	NUM
admet-2582	188	6	,	,	PUNCT
admet-2582	188	7	11	11	NUM
admet-2582	188	8	catabolites	catabolite	NOUN
admet-2582	188	9	were	be	AUX
admet-2582	188	10	identified	identify	VERB
admet-2582	188	11	,	,	PUNCT
admet-2582	188	12	including	include	VERB
admet-2582	188	13	mmae(m717	mmae(m717	PROPN
admet-2582	188	14	)	)	PUNCT
admet-2582	188	15	,	,	PUNCT
admet-2582	188	16	demethylation	demethylation	NOUN
admet-2582	188	17	,	,	PUNCT
admet-2582	188	18	and	and	CCONJ
admet-2582	188	19	mono	mono	NOUN
admet-2582	188	20	-	-	PUNCT
admet-2582	188	21	oxidation	oxidation	NOUN
admet-2582	188	22	metabolites	metabolite	NOUN
admet-2582	188	23	(	(	PUNCT
admet-2582	188	24	m719	m719	NUM
admet-2582	188	25	-	-	SYM
admet-2582	188	26	1	1	NUM
admet-2582	188	27	,	,	PUNCT
admet-2582	188	28	m719	m719	PROPN
admet-2582	188	29	-	-	SYM
admet-2582	188	30	2	2	NUM
admet-2582	188	31	,	,	PUNCT
admet-2582	188	32	m719	m719	PROPN
admet-2582	188	33	-	-	SYM
admet-2582	188	34	3	3	NUM
admet-2582	188	35	,	,	PUNCT
admet-2582	188	36	m719	m719	PROPN
admet-2582	188	37	-	-	SYM
admet-2582	188	38	4	4	NUM
admet-2582	188	39	,	,	PUNCT
admet-2582	188	40	and	and	CCONJ
admet-2582	188	41	m719	m719	NUM
admet-2582	188	42	-	-	SYM
admet-2582	188	43	5	5	NUM
admet-2582	188	44	)	)	PUNCT
admet-2582	188	45	,	,	PUNCT
admet-2582	188	46	mono	mono	NOUN
admet-2582	188	47	-	-	PUNCT
admet-2582	188	48	oxidation	oxidation	NOUN
admet-2582	188	49	metabolites	metabolite	NOUN
admet-2582	188	50	(	(	PUNCT
admet-2582	188	51	m733	m733	NUM
admet-2582	188	52	-	-	SYM
admet-2582	188	53	1	1	NUM
admet-2582	188	54	,	,	PUNCT
admet-2582	188	55	m733	m733	PROPN
admet-2582	188	56	-	-	SYM
admet-2582	188	57	2	2	NUM
admet-2582	188	58	,	,	PUNCT
admet-2582	188	59	and	and	CCONJ
admet-2582	188	60	m733	m733	NUM
admet-2582	188	61	-	-	SYM
admet-2582	188	62	4	4	NUM
admet-2582	188	63	)	)	PUNCT
admet-2582	188	64	,	,	PUNCT
admet-2582	188	65	demethylation	demethylation	NOUN
admet-2582	188	66	metabolite	metabolite	NOUN
admet-2582	188	67	(	(	PUNCT
admet-2582	188	68	m703	m703	NUM
admet-2582	188	69	-	-	SYM
admet-2582	188	70	1	1	NUM
admet-2582	188	71	)	)	PUNCT
admet-2582	188	72	,	,	PUNCT
admet-2582	188	73	oxidative	oxidative	ADJ
admet-2582	188	74	dehydrogenation	dehydrogenation	NOUN
admet-2582	188	75	metabolite	metabolite	NOUN
admet-2582	188	76	(	(	PUNCT
admet-2582	188	77	m731	m731	PROPN
admet-2582	188	78	-	-	PUNCT
admet-2582	188	79	2	2	NUM
admet-2582	188	80	)	)	PUNCT
admet-2582	188	81	.	.	PUNCT
admet-2582	189	1	mmae	mmae	PROPN
admet-2582	189	2	prototype	prototype	PROPN
admet-2582	189	3	was	be	AUX
admet-2582	189	4	detected	detect	VERB
admet-2582	189	5	in	in	ADP
admet-2582	189	6	bile	bile	NOUN
admet-2582	189	7	,	,	PUNCT
admet-2582	189	8	urine	urine	NOUN
admet-2582	189	9	,	,	PUNCT
admet-2582	189	10	fences	fence	NOUN
admet-2582	189	11	,	,	PUNCT
admet-2582	189	12	plasma	plasma	NOUN
admet-2582	189	13	,	,	PUNCT
admet-2582	189	14	and	and	CCONJ
admet-2582	189	15	tumour	tumour	NOUN
admet-2582	189	16	tissue	tissue	NOUN
admet-2582	189	17	,	,	PUNCT
admet-2582	189	18	all	all	DET
admet-2582	189	19	10	10	NUM
admet-2582	189	20	metabolites	metabolite	NOUN
admet-2582	189	21	of	of	ADP
admet-2582	189	22	mmae	mmae	NOUN
admet-2582	189	23	were	be	AUX
admet-2582	189	24	detected	detect	VERB
admet-2582	189	25	in	in	ADP
admet-2582	189	26	bile	bile	NOUN
admet-2582	189	27	,	,	PUNCT
admet-2582	189	28	and	and	CCONJ
admet-2582	189	29	m719	m719	NUM
admet-2582	189	30	-	-	SYM
admet-2582	189	31	5	5	NUM
admet-2582	189	32	,	,	PUNCT
admet-2582	189	33	m733	m733	PROPN
admet-2582	189	34	-	-	SYM
admet-2582	189	35	2	2	NUM
admet-2582	189	36	,	,	PUNCT
admet-2582	189	37	and	and	CCONJ
admet-2582	189	38	m703	m703	NUM
admet-2582	189	39	-	-	SYM
admet-2582	189	40	1	1	NUM
admet-2582	189	41	were	be	AUX
admet-2582	189	42	also	also	ADV
admet-2582	189	43	detected	detect	VERB
admet-2582	189	44	in	in	ADP
admet-2582	189	45	faeces	faece	NOUN
admet-2582	189	46	.	.	PUNCT
admet-2582	190	1	the	the	DET
admet-2582	190	2	main	main	ADJ
admet-2582	190	3	metabolic	metabolic	NOUN
admet-2582	190	4	pathways	pathway	NOUN
admet-2582	190	5	and	and	CCONJ
admet-2582	190	6	metabolites	metabolite	NOUN
admet-2582	190	7	of	of	ADP
admet-2582	190	8	[	[	PUNCT
admet-2582	190	9	3h	3h	NUM
admet-2582	190	10	-	-	PUNCT
admet-2582	190	11	mmae]rc48	mmae]rc48	NOUN
admet-2582	190	12	-	-	PUNCT
admet-2582	190	13	adc	adc	NOUN
admet-2582	190	14	in	in	ADP
admet-2582	190	15	rats	rat	NOUN
admet-2582	190	16	and	and	CCONJ
admet-2582	190	17	tumour	tumour	NOUN
admet-2582	190	18	-	-	PUNCT
admet-2582	190	19	bearing	bear	VERB
admet-2582	190	20	mice	mouse	NOUN
admet-2582	190	21	are	be	AUX
admet-2582	190	22	shown	show	VERB
admet-2582	190	23	in	in	ADP
admet-2582	190	24	figure	figure	NOUN
admet-2582	190	25	6	6	NUM
admet-2582	190	26	.	.	PUNCT
admet-2582	190	27	table	table	NOUN
admet-2582	190	28	2	2	NUM
admet-2582	190	29	.	.	PUNCT
admet-2582	190	30	metabolite	metabolite	NOUN
admet-2582	190	31	assignments	assignment	NOUN
admet-2582	190	32	and	and	CCONJ
admet-2582	190	33	proposed	propose	VERB
admet-2582	190	34	metabolic	metabolic	NOUN
admet-2582	190	35	transformation	transformation	NOUN
admet-2582	190	36	and	and	CCONJ
admet-2582	190	37	structure	structure	NOUN
admet-2582	190	38	for	for	ADP
admet-2582	190	39	11	11	NUM
admet-2582	190	40	metabolites	metabolite	NOUN
admet-2582	190	41	observed	observe	VERB
admet-2582	190	42	in	in	ADP
admet-2582	190	43	the	the	DET
admet-2582	190	44	excretion	excretion	NOUN
admet-2582	190	45	study	study	NOUN
admet-2582	190	46	.	.	PUNCT
admet-2582	191	1	no	no	INTJ
admet-2582	191	2	.	.	PUNCT
admet-2582	192	1	catabolites	catabolite	NOUN
admet-2582	192	2	protonated	protonate	VERB
admet-2582	192	3	molecular	molecular	ADJ
admet-2582	192	4	formula	formula	NOUN
admet-2582	192	5	m	m	PROPN
admet-2582	192	6	/	/	SYM
admet-2582	192	7	z	z	NOUN
admet-2582	192	8	for	for	ADP
admet-2582	192	9	[	[	X
admet-2582	192	10	m+h]+	m+h]+	PROPN
admet-2582	192	11	mass	mass	PROPN
admet-2582	192	12	accuracy	accuracy	NOUN
admet-2582	192	13	,	,	PUNCT
admet-2582	192	14	ppm	ppm	ADJ
admet-2582	192	15	origin	origin	NOUN
admet-2582	192	16	theoretical	theoretical	NOUN
admet-2582	192	17	measured	measure	VERB
admet-2582	192	18	1	1	NUM
admet-2582	192	19	m717	m717	PROPN
admet-2582	192	20	(	(	PUNCT
admet-2582	192	21	mmae	mmae	PROPN
admet-2582	192	22	)	)	PUNCT
admet-2582	192	23	c39h68n5o7	c39h68n5o7	PROPN
admet-2582	193	1	+	+	PROPN
admet-2582	193	2	718.5113	718.5113	NUM
admet-2582	193	3	718.5100	718.5100	NUM
admet-2582	193	4	-1.30	-1.30	ADJ
admet-2582	193	5	plasma	plasma	NOUN
admet-2582	193	6	/	/	SYM
admet-2582	193	7	bile	bile	NOUN
admet-2582	193	8	/	/	SYM
admet-2582	193	9	urine/	urine/	NUM
admet-2582	193	10	/faeces	/faece	NOUN
admet-2582	193	11	/	/	SYM
admet-2582	193	12	tumour	tumour	ADJ
admet-2582	193	13	tissue	tissue	NOUN
admet-2582	193	14	2	2	NUM
admet-2582	193	15	m719	m719	NUM
admet-2582	193	16	-	-	SYM
admet-2582	193	17	1	1	NUM
admet-2582	193	18	c38h66n5o8	c38h66n5o8	NOUN
admet-2582	193	19	+	+	NOUN
admet-2582	193	20	720.4906	720.4906	NUM
admet-2582	193	21	720.4895	720.4895	NUM
admet-2582	193	22	-1.10	-1.10	NOUN
admet-2582	193	23	bile	bile	NOUN
admet-2582	193	24	3	3	NUM
admet-2582	193	25	m719	m719	NUM
admet-2582	193	26	-	-	SYM
admet-2582	193	27	2	2	NUM
admet-2582	193	28	c38h66n5o8	c38h66n5o8	NOUN
admet-2582	193	29	+	+	CCONJ
admet-2582	193	30	720.4906	720.4906	NUM
admet-2582	193	31	720.4900	720.4900	NUM
admet-2582	193	32	-0.60	-0.60	NUM
admet-2582	193	33	bile	bile	NOUN
admet-2582	193	34	4	4	NUM
admet-2582	193	35	m719	m719	NUM
admet-2582	193	36	-	-	SYM
admet-2582	193	37	3	3	NUM
admet-2582	193	38	c38h66n5o8	c38h66n5o8	PROPN
admet-2582	193	39	+	+	CCONJ
admet-2582	193	40	720.4906	720.4906	NUM
admet-2582	193	41	720.4891	720.4891	NUM
admet-2582	193	42	-1.50	-1.50	NUM
admet-2582	193	43	bile	bile	NOUN
admet-2582	193	44	5	5	NUM
admet-2582	193	45	m719	m719	NUM
admet-2582	193	46	-	-	SYM
admet-2582	193	47	4	4	NUM
admet-2582	193	48	c38h66n5o8	c38h66n5o8	NOUN
admet-2582	193	49	+	+	NOUN
admet-2582	193	50	720.4906	720.4906	NUM
admet-2582	193	51	720.4896	720.4896	NUM
admet-2582	193	52	-1.00	-1.00	NUM
admet-2582	193	53	bile	bile	NOUN
admet-2582	193	54	6	6	NUM
admet-2582	193	55	m719	m719	NUM
admet-2582	193	56	-	-	SYM
admet-2582	193	57	5	5	NUM
admet-2582	193	58	c38h66n5o8	c38h66n5o8	NOUN
admet-2582	193	59	+	+	CCONJ
admet-2582	193	60	720.4906	720.4906	NUM
admet-2582	193	61	720.4895	720.4895	NUM
admet-2582	193	62	-1.10	-1.10	NOUN
admet-2582	193	63	bile	bile	NOUN
admet-2582	193	64	/	/	SYM
admet-2582	193	65	faeces	faece	NOUN
admet-2582	193	66	7	7	NUM
admet-2582	193	67	m733	m733	NUM
admet-2582	193	68	-	-	SYM
admet-2582	193	69	1	1	NUM
admet-2582	193	70	c38h68n5o8	c38h68n5o8	PROPN
admet-2582	193	71	+	+	CCONJ
admet-2582	193	72	734.5062	734.5062	NUM
admet-2582	193	73	734.5051	734.5051	NUM
admet-2582	193	74	-1.10	-1.10	NOUN
admet-2582	193	75	bile	bile	NOUN
admet-2582	193	76	8	8	NUM
admet-2582	193	77	m733	m733	NUM
admet-2582	193	78	-	-	SYM
admet-2582	193	79	2	2	NUM
admet-2582	193	80	c38h68n5o8	c38h68n5o8	NOUN
admet-2582	193	81	+	+	CCONJ
admet-2582	193	82	734.5062	734.5062	NUM
admet-2582	193	83	734.5048	734.5048	NUM
admet-2582	193	84	-1.40	-1.40	NUM
admet-2582	193	85	bile	bile	NOUN
admet-2582	193	86	/	/	SYM
admet-2582	193	87	faeces	faece	NOUN
admet-2582	193	88	9	9	NUM
admet-2582	193	89	m733	m733	NUM
admet-2582	193	90	-	-	SYM
admet-2582	193	91	4	4	NUM
admet-2582	193	92	c38h68n5o8	c38h68n5o8	NOUN
admet-2582	193	93	+	+	CCONJ
admet-2582	193	94	734.5062	734.5062	NUM
admet-2582	193	95	734.5053	734.5053	NUM
admet-2582	193	96	-0.90	-0.90	NUM
admet-2582	193	97	bile	bile	NOUN
admet-2582	193	98	10	10	NUM
admet-2582	193	99	m703	m703	NUM
admet-2582	193	100	-	-	SYM
admet-2582	193	101	1	1	NUM
admet-2582	193	102	c38h66n5o7	c38h66n5o7	NOUN
admet-2582	193	103	+	+	NOUN
admet-2582	193	104	704.4957	704.4957	NOUN
admet-2582	193	105	704.4943	704.4943	NUM
admet-2582	193	106	-1.40	-1.40	NUM
admet-2582	193	107	bile	bile	NOUN
admet-2582	193	108	/	/	SYM
admet-2582	193	109	faeces	faece	NOUN
admet-2582	193	110	11	11	NUM
admet-2582	193	111	m731	m731	PROPN
admet-2582	193	112	-	-	SYM
admet-2582	193	113	2	2	NUM
admet-2582	193	114	c39h66n5o8	c39h66n5o8	NOUN
admet-2582	193	115	+	+	NOUN
admet-2582	193	116	732.4906	732.4906	NUM
admet-2582	193	117	732.4887	732.4887	NUM
admet-2582	193	118	-1.90	-1.90	NUM
admet-2582	193	119	bile	bile	NOUN
admet-2582	193	120	in	in	ADP
admet-2582	193	121	the	the	DET
admet-2582	193	122	collected	collected	ADJ
admet-2582	193	123	bile	bile	NOUN
admet-2582	193	124	and	and	CCONJ
admet-2582	193	125	urine	urine	NOUN
admet-2582	193	126	samples	sample	NOUN
admet-2582	193	127	,	,	PUNCT
admet-2582	193	128	eight	eight	NUM
admet-2582	193	129	catabolites	catabolite	NOUN
admet-2582	193	130	,	,	PUNCT
admet-2582	193	131	including	include	VERB
admet-2582	193	132	mmae	mmae	NOUN
admet-2582	193	133	of	of	ADP
admet-2582	193	134	the	the	DET
admet-2582	193	135	polatuzumab	polatuzumab	NOUN
admet-2582	193	136	vedotin	vedotin	ADJ
admet-2582	193	137	(	(	PUNCT
admet-2582	193	138	polivy	polivy	PROPN
admet-2582	193	139	®	®	PROPN
admet-2582	193	140	)	)	PUNCT
admet-2582	193	141	,	,	PUNCT
admet-2582	193	142	were	be	AUX
admet-2582	193	143	observed	observe	VERB
admet-2582	193	144	[	[	X
admet-2582	193	145	14	14	NUM
admet-2582	193	146	]	]	PUNCT
admet-2582	193	147	.	.	PUNCT
admet-2582	194	1	for	for	ADP
admet-2582	194	2	brentuximab	brentuximab	NOUN
admet-2582	194	3	vedotin	vedotin	NOUN
admet-2582	194	4	,	,	PUNCT
admet-2582	194	5	twelve	twelve	NUM
admet-2582	194	6	metabolites	metabolite	NOUN
admet-2582	194	7	were	be	AUX
admet-2582	194	8	identified	identify	VERB
admet-2582	194	9	in	in	ADP
admet-2582	194	10	vitro	vitro	X
admet-2582	194	11	in	in	ADP
admet-2582	194	12	different	different	ADJ
admet-2582	194	13	species	specie	NOUN
admet-2582	194	14	of	of	ADP
admet-2582	194	15	hepatocyte	hepatocyte	NOUN
admet-2582	194	16	metabolites	metabolite	NOUN
admet-2582	194	17	identification	identification	NOUN
admet-2582	194	18	experiments[13	experiments[13	NOUN
admet-2582	194	19	]	]	PUNCT
admet-2582	194	20	.	.	PUNCT
admet-2582	195	1	according	accord	VERB
admet-2582	195	2	to	to	ADP
admet-2582	195	3	the	the	DET
admet-2582	195	4	results	result	NOUN
admet-2582	195	5	of	of	ADP
admet-2582	195	6	the	the	DET
admet-2582	195	7	metabolites	metabolite	NOUN
admet-2582	195	8	study	study	NOUN
admet-2582	195	9	,	,	PUNCT
admet-2582	195	10	a	a	DET
admet-2582	195	11	total	total	NOUN
admet-2582	195	12	of	of	ADP
admet-2582	195	13	11	11	NUM
admet-2582	195	14	metabolites	metabolite	NOUN
admet-2582	195	15	were	be	AUX
admet-2582	195	16	identified	identify	VERB
admet-2582	195	17	,	,	PUNCT
admet-2582	195	18	and	and	CCONJ
admet-2582	195	19	the	the	DET
admet-2582	195	20	mmae	mmae	NOUN
admet-2582	195	21	prototype	prototype	NOUN
admet-2582	195	22	was	be	AUX
admet-2582	195	23	detected	detect	VERB
admet-2582	195	24	in	in	ADP
admet-2582	195	25	bile	bile	NOUN
admet-2582	195	26	,	,	PUNCT
admet-2582	195	27	urine	urine	NOUN
admet-2582	195	28	,	,	PUNCT
admet-2582	195	29	faeces	faece	NOUN
admet-2582	195	30	,	,	PUNCT
admet-2582	195	31	plasma	plasma	NOUN
admet-2582	195	32	,	,	PUNCT
admet-2582	195	33	and	and	CCONJ
admet-2582	195	34	tumour	tumour	NOUN
admet-2582	195	35	tissue	tissue	NOUN
admet-2582	195	36	.	.	PUNCT
admet-2582	196	1	all	all	DET
admet-2582	196	2	10	10	NUM
admet-2582	196	3	metabolites	metabolite	NOUN
admet-2582	196	4	of	of	ADP
admet-2582	196	5	mmae	mmae	NOUN
admet-2582	196	6	were	be	AUX
admet-2582	196	7	detected	detect	VERB
admet-2582	196	8	in	in	ADP
admet-2582	196	9	bile	bile	NOUN
admet-2582	196	10	,	,	PUNCT
admet-2582	196	11	and	and	CCONJ
admet-2582	196	12	m719	m719	NUM
admet-2582	196	13	-	-	SYM
admet-2582	196	14	5	5	NUM
admet-2582	196	15	,	,	PUNCT
admet-2582	196	16	m733	m733	PROPN
admet-2582	196	17	-	-	SYM
admet-2582	196	18	2	2	NUM
admet-2582	196	19	and	and	CCONJ
admet-2582	196	20	m703	m703	NUM
admet-2582	196	21	-	-	SYM
admet-2582	196	22	1	1	NUM
admet-2582	196	23	were	be	AUX
admet-2582	196	24	also	also	ADV
admet-2582	196	25	detected	detect	VERB
admet-2582	196	26	in	in	ADP
admet-2582	196	27	faeces	faece	NOUN
admet-2582	196	28	.	.	PUNCT
admet-2582	197	1	this	this	PRON
admet-2582	197	2	is	be	AUX
admet-2582	197	3	further	further	ADJ
admet-2582	197	4	evidence	evidence	NOUN
admet-2582	197	5	that	that	SCONJ
admet-2582	197	6	rc48	rc48	PROPN
admet-2582	197	7	-	-	PUNCT
admet-2582	197	8	adc	adc	PROPN
admet-2582	197	9	was	be	AUX
admet-2582	197	10	mainly	mainly	ADV
admet-2582	197	11	eliminated	eliminate	VERB
admet-2582	197	12	through	through	ADP
admet-2582	197	13	renal	renal	ADJ
admet-2582	197	14	excretion	excretion	NOUN
admet-2582	197	15	.	.	PUNCT
admet-2582	198	1	the	the	DET
admet-2582	198	2	elimination	elimination	NOUN
admet-2582	198	3	of	of	ADP
admet-2582	198	4	[	[	X
admet-2582	198	5	3h]-mmae	3h]-mmae	NUM
admet-2582	198	6	-	-	PUNCT
admet-2582	198	7	rc48	rc48	PROPN
admet-2582	198	8	-	-	PUNCT
admet-2582	198	9	adc	adc	PROPN
admet-2582	198	10	was	be	AUX
admet-2582	198	11	mainly	mainly	ADV
admet-2582	198	12	through	through	ADP
admet-2582	198	13	biliary	biliary	NOUN
admet-2582	198	14	admet	admet	PROPN
admet-2582	198	15	&	&	CCONJ
admet-2582	198	16	dmpk	dmpk	PROPN
admet-2582	198	17	13(2	13(2	PROPN
admet-2582	198	18	)	)	PUNCT
admet-2582	198	19	(	(	PUNCT
admet-2582	198	20	2025	2025	NUM
admet-2582	198	21	)	)	PUNCT
admet-2582	198	22	2582	2582	NUM
admet-2582	198	23	disitamab	disitamab	VERB
admet-2582	198	24	vedotin	vedotin	ADJ
admet-2582	198	25	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	198	26	,	,	PUNCT
admet-2582	198	27	distribution	distribution	NOUN
admet-2582	198	28	and	and	CCONJ
admet-2582	198	29	metabolism	metabolism	NOUN
admet-2582	198	30	doi	doi	NOUN
admet-2582	198	31	:	:	PUNCT
admet-2582	198	32	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	198	33	11	11	NUM
admet-2582	198	34	faecal	faecal	ADJ
admet-2582	198	35	secretion	secretion	NOUN
admet-2582	198	36	,	,	PUNCT
admet-2582	198	37	and	and	CCONJ
admet-2582	198	38	this	this	DET
admet-2582	198	39	claim	claim	NOUN
admet-2582	198	40	was	be	AUX
admet-2582	198	41	also	also	ADV
admet-2582	198	42	approved	approve	VERB
admet-2582	198	43	when	when	SCONJ
admet-2582	198	44	we	we	PRON
admet-2582	198	45	characterized	characterize	VERB
admet-2582	198	46	the	the	DET
admet-2582	198	47	catabolites	catabolite	NOUN
admet-2582	198	48	found	find	VERB
admet-2582	198	49	in	in	ADP
admet-2582	198	50	urine	urine	NOUN
admet-2582	198	51	and	and	CCONJ
admet-2582	198	52	bile	bile	NOUN
admet-2582	198	53	.	.	PUNCT
admet-2582	199	1	yip	yip	PROPN
admet-2582	199	2	,	,	PUNCT
admet-2582	199	3	victor	victor	PROPN
admet-2582	199	4	et	et	PROPN
admet-2582	199	5	al	al	PROPN
admet-2582	199	6	.	.	PUNCT
admet-2582	200	1	[	[	X
admet-2582	200	2	14	14	NUM
admet-2582	200	3	]	]	PUNCT
admet-2582	200	4	have	have	AUX
admet-2582	200	5	reported	report	VERB
admet-2582	200	6	that	that	SCONJ
admet-2582	200	7	the	the	DET
admet-2582	200	8	elimination	elimination	NOUN
admet-2582	200	9	of	of	ADP
admet-2582	200	10	[	[	X
admet-2582	200	11	3h]-mmae	3h]-mmae	NUM
admet-2582	200	12	-	-	PUNCT
admet-2582	200	13	polatuzumab	polatuzumab	NOUN
admet-2582	200	14	vedotin	vedotin	NOUN
admet-2582	200	15	in	in	ADP
admet-2582	200	16	rats	rat	NOUN
admet-2582	200	17	was	be	AUX
admet-2582	200	18	mainly	mainly	ADV
admet-2582	200	19	through	through	ADP
admet-2582	200	20	a	a	DET
admet-2582	200	21	faecal	faecal	ADJ
admet-2582	200	22	–	–	PUNCT
admet-2582	200	23	biliary	biliary	ADJ
admet-2582	200	24	path	path	NOUN
admet-2582	200	25	.	.	PUNCT
admet-2582	201	1	meanwhile	meanwhile	ADV
admet-2582	201	2	,	,	PUNCT
admet-2582	201	3	han	han	PROPN
admet-2582	201	4	et	et	PROPN
admet-2582	201	5	al	al	PROPN
admet-2582	201	6	.	.	PUNCT
admet-2582	202	1	[	[	X
admet-2582	202	2	15	15	NUM
admet-2582	202	3	]	]	PUNCT
admet-2582	202	4	also	also	ADV
admet-2582	202	5	found	find	VERB
admet-2582	202	6	that	that	SCONJ
admet-2582	202	7	patients	patient	NOUN
admet-2582	202	8	with	with	ADP
admet-2582	202	9	cd30	cd30	PROPN
admet-2582	202	10	-	-	PUNCT
admet-2582	202	11	positive	positive	ADJ
admet-2582	202	12	hematologic	hematologic	NOUN
admet-2582	202	13	malignancies	malignancy	NOUN
admet-2582	202	14	were	be	AUX
admet-2582	202	15	given	give	VERB
admet-2582	202	16	brentuximab	brentuximab	NOUN
admet-2582	202	17	vedotin	vedotin	NOUN
admet-2582	202	18	,	,	PUNCT
admet-2582	202	19	the	the	DET
admet-2582	202	20	primary	primary	ADJ
admet-2582	202	21	excretion	excretion	NOUN
admet-2582	202	22	route	route	NOUN
admet-2582	202	23	of	of	ADP
admet-2582	202	24	mmae	mmae	NOUN
admet-2582	202	25	is	be	AUX
admet-2582	202	26	via	via	ADP
admet-2582	202	27	faeces	faece	NOUN
admet-2582	202	28	and	and	CCONJ
admet-2582	202	29	most	most	ADJ
admet-2582	202	30	in	in	ADP
admet-2582	202	31	prototype	prototype	NOUN
admet-2582	202	32	form	form	NOUN
admet-2582	202	33	,	,	PUNCT
admet-2582	202	34	which	which	PRON
admet-2582	202	35	corroborated	corroborate	VERB
admet-2582	202	36	with	with	ADP
admet-2582	202	37	our	our	PRON
admet-2582	202	38	result	result	NOUN
admet-2582	202	39	as	as	ADP
admet-2582	202	40	polatuzumab	polatuzumab	NOUN
admet-2582	202	41	vedotin	vedotin	ADV
admet-2582	202	42	and	and	CCONJ
admet-2582	202	43	brentuximab	brentuximab	VERB
admet-2582	202	44	vedotin	vedotin	ADV
admet-2582	202	45	utilized	utilize	VERB
admet-2582	202	46	the	the	DET
admet-2582	202	47	same	same	ADJ
admet-2582	202	48	linker	linker	NOUN
admet-2582	202	49	and	and	CCONJ
admet-2582	202	50	payload	payload	ADJ
admet-2582	202	51	asrc48	asrc48	NOUN
admet-2582	202	52	-	-	PUNCT
admet-2582	202	53	adc	adc	PROPN
admet-2582	202	54	.	.	PUNCT
admet-2582	203	1	moreover	moreover	ADV
admet-2582	203	2	,	,	PUNCT
admet-2582	203	3	we	we	PRON
admet-2582	203	4	also	also	ADV
admet-2582	203	5	found	find	VERB
admet-2582	203	6	that	that	SCONJ
admet-2582	203	7	the	the	DET
admet-2582	203	8	average	average	ADJ
admet-2582	203	9	total	total	ADJ
admet-2582	203	10	radiation	radiation	NOUN
admet-2582	203	11	recovery	recovery	NOUN
admet-2582	203	12	rate	rate	NOUN
admet-2582	203	13	(	(	PUNCT
admet-2582	203	14	64.46	64.46	NUM
admet-2582	203	15	%	%	NOUN
admet-2582	203	16	)	)	PUNCT
admet-2582	203	17	of	of	ADP
admet-2582	203	18	biliary	biliary	NOUN
admet-2582	203	19	duct	duct	NOUN
admet-2582	203	20	intubation	intubation	NOUN
admet-2582	203	21	rats	rat	NOUN
admet-2582	203	22	was	be	AUX
admet-2582	203	23	higher	high	ADJ
admet-2582	203	24	than	than	ADP
admet-2582	203	25	that	that	PRON
admet-2582	203	26	of	of	ADP
admet-2582	203	27	normal	normal	ADJ
admet-2582	203	28	rats	rat	NOUN
admet-2582	203	29	(	(	PUNCT
admet-2582	203	30	54.33	54.33	NUM
admet-2582	203	31	%	%	NOUN
admet-2582	203	32	)	)	PUNCT
admet-2582	203	33	at	at	ADP
admet-2582	203	34	the	the	DET
admet-2582	203	35	same	same	ADJ
admet-2582	203	36	time	time	NOUN
admet-2582	203	37	,	,	PUNCT
admet-2582	203	38	suggesting	suggest	VERB
admet-2582	203	39	the	the	DET
admet-2582	203	40	possibility	possibility	NOUN
admet-2582	203	41	of	of	ADP
admet-2582	203	42	hepatoenteral	hepatoenteral	ADJ
admet-2582	203	43	circulation	circulation	NOUN
admet-2582	203	44	.	.	PUNCT
admet-2582	204	1	figure	figure	NOUN
admet-2582	204	2	6	6	NUM
admet-2582	204	3	.	.	PUNCT
admet-2582	205	1	major	major	ADJ
admet-2582	205	2	metabolic	metabolic	NOUN
admet-2582	205	3	pathways	pathway	NOUN
admet-2582	205	4	of	of	ADP
admet-2582	205	5	[	[	X
admet-2582	205	6	3h]-labelled	3h]-labelled	NUM
admet-2582	205	7	disitamab	disitamab	NOUN
admet-2582	205	8	vedotin	vedotin	NOUN
admet-2582	205	9	in	in	ADP
admet-2582	205	10	rats	rat	NOUN
admet-2582	205	11	/	/	SYM
admet-2582	205	12	mice	mouse	NOUN
admet-2582	205	13	.	.	PUNCT
admet-2582	206	1	p	p	X
admet-2582	206	2	:	:	PUNCT
admet-2582	206	3	plasma	plasma	NOUN
admet-2582	206	4	,	,	PUNCT
admet-2582	206	5	represented	represent	VERB
admet-2582	206	6	by	by	ADP
admet-2582	206	7	rate	rate	NOUN
admet-2582	206	8	,	,	PUNCT
admet-2582	206	9	%	%	NOUN
admet-2582	206	10	in	in	ADP
admet-2582	206	11	b	b	NOUN
admet-2582	206	12	:	:	PUNCT
admet-2582	206	13	bile	bile	NOUN
admet-2582	206	14	,	,	PUNCT
admet-2582	206	15	u	u	NOUN
admet-2582	206	16	:	:	PUNCT
admet-2582	206	17	urine	urine	NOUN
admet-2582	206	18	,	,	PUNCT
admet-2582	206	19	f	f	X
admet-2582	206	20	:	:	PUNCT
admet-2582	206	21	faeces	faece	NOUN
admet-2582	206	22	,	,	PUNCT
admet-2582	206	23	representing	represent	VERB
admet-2582	206	24	and	and	CCONJ
admet-2582	206	25	stool	stool	NOUN
admet-2582	206	26	,	,	PUNCT
admet-2582	206	27	respectively	respectively	ADV
admet-2582	206	28	,	,	PUNCT
admet-2582	206	29	represented	represent	VERB
admet-2582	206	30	by	by	ADP
admet-2582	206	31	dose	dose	PROPN
admet-2582	206	32	,	,	PUNCT
admet-2582	206	33	%	%	INTJ
admet-2582	206	34	;	;	PUNCT
admet-2582	206	35	t	t	X
admet-2582	206	36	:	:	PUNCT
admet-2582	206	37	tumour	tumour	ADJ
admet-2582	206	38	tissue	tissue	NOUN
admet-2582	206	39	,	,	PUNCT
admet-2582	206	40	represented	represent	VERB
admet-2582	206	41	by	by	ADP
admet-2582	206	42	rate	rate	NOUN
admet-2582	206	43	,	,	PUNCT
admet-2582	206	44	%	%	NOUN
admet-2582	206	45	of	of	ADP
admet-2582	206	46	f	f	NOUN
admet-2582	206	47	:	:	PUNCT
admet-2582	206	48	female	female	ADJ
admet-2582	206	49	and	and	CCONJ
admet-2582	206	50	m	m	ADJ
admet-2582	206	51	:	:	PUNCT
admet-2582	206	52	male	male	ADJ
admet-2582	206	53	rats	rat	NOUN
admet-2582	206	54	with	with	ADP
admet-2582	206	55	tumour	tumour	NOUN
admet-2582	206	56	tissue	tissue	NOUN
admet-2582	206	57	conclusion	conclusion	NOUN
admet-2582	206	58	in	in	ADP
admet-2582	206	59	summary	summary	NOUN
admet-2582	206	60	,	,	PUNCT
admet-2582	206	61	the	the	DET
admet-2582	206	62	results	result	NOUN
admet-2582	206	63	showed	show	VERB
admet-2582	206	64	good	good	ADJ
admet-2582	206	65	plasma	plasma	NOUN
admet-2582	206	66	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	206	67	and	and	CCONJ
admet-2582	206	68	excellent	excellent	ADJ
admet-2582	206	69	targeting	targeting	NOUN
admet-2582	206	70	to	to	ADP
admet-2582	206	71	tumours	tumour	NOUN
admet-2582	206	72	for	for	ADP
admet-2582	206	73	disitamab	disitamab	NOUN
admet-2582	206	74	edotin	edotin	NOUN
admet-2582	206	75	and	and	CCONJ
admet-2582	206	76	effective	effective	ADJ
admet-2582	206	77	detoxification	detoxification	NOUN
admet-2582	206	78	during	during	ADP
admet-2582	206	79	hepatobiliary	hepatobiliary	ADJ
admet-2582	206	80	/	/	SYM
admet-2582	206	81	bile	bile	NOUN
admet-2582	206	82	elimination	elimination	NOUN
admet-2582	206	83	for	for	ADP
admet-2582	206	84	disitamab	disitamab	NOUN
admet-2582	206	85	vedotin	vedotin	NOUN
admet-2582	206	86	is	be	AUX
admet-2582	206	87	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	206	88	m.	m.	NOUN
admet-2582	207	1	das	das	PROPN
admet-2582	207	2	et	et	PROPN
admet-2582	207	3	al	al	PROPN
admet-2582	207	4	.	.	PROPN
admet-2582	207	5	admet	admet	PROPN
admet-2582	207	6	&	&	CCONJ
admet-2582	207	7	dmpk	dmpk	PROPN
admet-2582	207	8	13(2	13(2	PROPN
admet-2582	207	9	)	)	PUNCT
admet-2582	207	10	(	(	PUNCT
admet-2582	207	11	2025	2025	NUM
admet-2582	207	12	)	)	PUNCT
admet-2582	207	13	2582	2582	NUM
admet-2582	207	14	12	12	NUM
admet-2582	207	15	consistent	consistent	ADJ
admet-2582	207	16	with	with	ADP
admet-2582	207	17	its	its	PRON
admet-2582	207	18	favourable	favourable	ADJ
admet-2582	207	19	safety	safety	NOUN
admet-2582	207	20	profiles	profile	NOUN
admet-2582	207	21	.	.	PUNCT
admet-2582	208	1	continued	continue	VERB
admet-2582	208	2	understanding	understanding	NOUN
admet-2582	208	3	of	of	ADP
admet-2582	208	4	the	the	DET
admet-2582	208	5	adme	adme	NOUN
admet-2582	208	6	properties	property	NOUN
admet-2582	208	7	of	of	ADP
admet-2582	208	8	disitamab	disitamab	NOUN
admet-2582	208	9	vedotin	vedotin	ADV
admet-2582	208	10	should	should	AUX
admet-2582	208	11	provide	provide	VERB
admet-2582	208	12	more	more	ADJ
admet-2582	208	13	theoretical	theoretical	ADJ
admet-2582	208	14	basis	basis	NOUN
admet-2582	208	15	and	and	CCONJ
admet-2582	208	16	data	datum	NOUN
admet-2582	208	17	support	support	NOUN
admet-2582	208	18	for	for	ADP
admet-2582	208	19	clinical	clinical	ADJ
admet-2582	208	20	and	and	CCONJ
admet-2582	208	21	additional	additional	ADJ
admet-2582	208	22	insight	insight	NOUN
admet-2582	208	23	into	into	ADP
admet-2582	208	24	what	what	PRON
admet-2582	208	25	attributes	attribute	NOUN
admet-2582	208	26	may	may	AUX
admet-2582	208	27	be	be	AUX
admet-2582	208	28	necessary	necessary	ADJ
admet-2582	208	29	for	for	ADP
admet-2582	208	30	better	well	ADJ
admet-2582	208	31	clinical	clinical	ADJ
admet-2582	208	32	application	application	NOUN
admet-2582	208	33	.	.	PUNCT
admet-2582	209	1	to	to	PART
admet-2582	209	2	better	well	ADV
admet-2582	209	3	understand	understand	VERB
admet-2582	209	4	or	or	CCONJ
admet-2582	209	5	predict	predict	VERB
admet-2582	209	6	the	the	DET
admet-2582	209	7	characteristics	characteristic	NOUN
admet-2582	209	8	of	of	ADP
admet-2582	209	9	adme	adme	NOUN
admet-2582	209	10	in	in	ADP
admet-2582	209	11	vivo	vivo	NOUN
admet-2582	209	12	of	of	ADP
admet-2582	209	13	rc48	rc48	PROPN
admet-2582	209	14	-	-	PUNCT
admet-2582	209	15	adc	adc	PROPN
admet-2582	209	16	,	,	PUNCT
admet-2582	209	17	the	the	DET
admet-2582	209	18	best	good	ADJ
admet-2582	209	19	efficacy	efficacy	NOUN
admet-2582	209	20	and	and	CCONJ
admet-2582	209	21	safety	safety	NOUN
admet-2582	209	22	when	when	SCONJ
admet-2582	209	23	applied	apply	VERB
admet-2582	209	24	to	to	ADP
admet-2582	209	25	clinical	clinical	ADJ
admet-2582	209	26	patients	patient	NOUN
admet-2582	209	27	must	must	AUX
admet-2582	209	28	be	be	AUX
admet-2582	209	29	achieved	achieve	VERB
admet-2582	209	30	.	.	PUNCT
admet-2582	210	1	hot	hot	ADJ
admet-2582	210	2	and	and	CCONJ
admet-2582	210	3	emerging	emerge	VERB
admet-2582	210	4	applications	application	NOUN
admet-2582	210	5	such	such	ADJ
admet-2582	210	6	as	as	ADP
admet-2582	210	7	drug	drug	NOUN
admet-2582	210	8	-	-	PUNCT
admet-2582	210	9	drug	drug	NOUN
admet-2582	210	10	interaction	interaction	NOUN
admet-2582	210	11	(	(	PUNCT
admet-2582	210	12	ddi	ddi	PROPN
admet-2582	210	13	)	)	PUNCT
admet-2582	210	14	(	(	PUNCT
admet-2582	210	15	predicting	predict	VERB
admet-2582	210	16	the	the	DET
admet-2582	210	17	safety	safety	NOUN
admet-2582	210	18	of	of	ADP
admet-2582	210	19	combination	combination	NOUN
admet-2582	210	20	with	with	ADP
admet-2582	210	21	small	small	ADJ
admet-2582	210	22	molecules	molecule	NOUN
admet-2582	210	23	or	or	CCONJ
admet-2582	210	24	biomacromolecules	biomacromolecule	NOUN
admet-2582	210	25	)	)	PUNCT
admet-2582	210	26	and	and	CCONJ
admet-2582	210	27	pk	pk	PROPN
admet-2582	210	28	/	/	SYM
admet-2582	210	29	pd	pd	NOUN
admet-2582	210	30	modelling	modelling	NOUN
admet-2582	210	31	(	(	PUNCT
admet-2582	210	32	predicting	predict	VERB
admet-2582	210	33	/	/	SYM
admet-2582	210	34	optimizing	optimize	VERB
admet-2582	210	35	clinical	clinical	ADJ
admet-2582	210	36	dose	dose	NOUN
admet-2582	210	37	scheme	scheme	NOUN
admet-2582	210	38	design	design	NOUN
admet-2582	210	39	)	)	PUNCT
admet-2582	210	40	deserve	deserve	VERB
admet-2582	210	41	more	more	ADJ
admet-2582	210	42	attention	attention	NOUN
admet-2582	210	43	and	and	CCONJ
admet-2582	210	44	application	application	NOUN
admet-2582	210	45	.	.	PUNCT
admet-2582	211	1	funding	funding	NOUN
admet-2582	211	2	source	source	NOUN
admet-2582	211	3	:	:	PUNCT
admet-2582	211	4	united	unite	VERB
admet-2582	211	5	-	-	PUNCT
admet-2582	211	6	power	power	PROPN
admet-2582	211	7	pharmatech	pharmatech	PROPN
admet-2582	211	8	co.	co.	PROPN
admet-2582	211	9	ltd	ltd	PROPN
admet-2582	211	10	.	.	PUNCT
admet-2582	212	1	ethics	ethic	NOUN
admet-2582	212	2	approval	approval	NOUN
admet-2582	212	3	:	:	PUNCT
admet-2582	212	4	all	all	DET
admet-2582	212	5	animal	animal	NOUN
admet-2582	212	6	study	study	NOUN
admet-2582	212	7	protocols	protocol	NOUN
admet-2582	212	8	were	be	AUX
admet-2582	212	9	approved	approve	VERB
admet-2582	212	10	by	by	ADP
admet-2582	212	11	the	the	DET
admet-2582	212	12	animal	animal	NOUN
admet-2582	212	13	management	management	NOUN
admet-2582	212	14	and	and	CCONJ
admet-2582	212	15	use	use	VERB
admet-2582	212	16	committee	committee	NOUN
admet-2582	212	17	before	before	ADP
admet-2582	212	18	implementation	implementation	NOUN
admet-2582	212	19	.	.	PUNCT
admet-2582	213	1	conflict	conflict	NOUN
admet-2582	213	2	of	of	ADP
admet-2582	213	3	interest	interest	NOUN
admet-2582	213	4	:	:	PUNCT
admet-2582	213	5	none	none	NOUN
admet-2582	213	6	references	reference	VERB
admet-2582	213	7	[	[	X
admet-2582	213	8	1	1	NUM
admet-2582	213	9	]	]	X
admet-2582	213	10	u.	u.	PROPN
admet-2582	213	11	hafeez	hafeez	PROPN
admet-2582	213	12	,	,	PUNCT
admet-2582	213	13	s.	s.	PROPN
admet-2582	213	14	parakh	parakh	PROPN
admet-2582	213	15	,	,	PUNCT
admet-2582	213	16	h.k	h.k	PROPN
admet-2582	213	17	.	.	PROPN
admet-2582	213	18	gan	gan	PROPN
admet-2582	213	19	,	,	PUNCT
admet-2582	213	20	a.m.	a.m.	PROPN
admet-2582	213	21	scott	scott	PROPN
admet-2582	213	22	.	.	PUNCT
admet-2582	214	1	antibody	antibody	NOUN
admet-2582	214	2	-	-	PUNCT
admet-2582	214	3	drug	drug	NOUN
admet-2582	214	4	conjugates	conjugate	NOUN
admet-2582	214	5	for	for	ADP
admet-2582	214	6	cancer	cancer	NOUN
admet-2582	214	7	therapy	therapy	NOUN
admet-2582	214	8	.	.	PUNCT
admet-2582	215	1	molecules	molecule	NOUN
admet-2582	215	2	25	25	NUM
admet-2582	215	3	(	(	PUNCT
admet-2582	215	4	2020	2020	NUM
admet-2582	215	5	)	)	PUNCT
admet-2582	215	6	4764	4764	NUM
admet-2582	215	7	.	.	PUNCT
admet-2582	216	1	https://doi.org/10.3390/molecules25204764	https://doi.org/10.3390/molecules25204764	NOUN
admet-2582	217	1	[	[	X
admet-2582	217	2	2	2	NUM
admet-2582	217	3	]	]	X
admet-2582	217	4	c.	c.	NOUN
admet-2582	217	5	do	do	AUX
admet-2582	217	6	pazo	pazo	NOUN
admet-2582	217	7	,	,	PUNCT
admet-2582	217	8	k.	k.	PROPN
admet-2582	217	9	nawaz	nawaz	PROPN
admet-2582	217	10	,	,	PUNCT
admet-2582	217	11	r.m	r.m	PROPN
admet-2582	217	12	.	.	PROPN
admet-2582	217	13	webster	webster	PROPN
admet-2582	217	14	.	.	PUNCT
admet-2582	218	1	the	the	DET
admet-2582	218	2	oncology	oncology	NOUN
admet-2582	218	3	market	market	NOUN
admet-2582	218	4	for	for	ADP
admet-2582	218	5	antibody	antibody	NOUN
admet-2582	218	6	-	-	PUNCT
admet-2582	218	7	drug	drug	NOUN
admet-2582	218	8	conjugates	conjugate	NOUN
admet-2582	218	9	.	.	PUNCT
admet-2582	219	1	nat	nat	PROPN
admet-2582	219	2	.	.	PUNCT
admet-2582	220	1	rev	rev	PROPN
admet-2582	220	2	.	.	PROPN
admet-2582	220	3	drug	drug	NOUN
admet-2582	220	4	discovery	discovery	PROPN
admet-2582	220	5	20	20	NUM
admet-2582	220	6	(	(	PUNCT
admet-2582	220	7	2021	2021	NUM
admet-2582	220	8	)	)	PUNCT
admet-2582	220	9	583	583	NUM
admet-2582	220	10	-	-	SYM
admet-2582	220	11	584	584	NUM
admet-2582	220	12	.	.	PUNCT
admet-2582	221	1	https://doi.org/10.1038/d41573-021-00054-2	https://doi.org/10.1038/d41573-021-00054-2	NOUN
admet-2582	222	1	[	[	X
admet-2582	222	2	3	3	X
admet-2582	222	3	]	]	PUNCT
admet-2582	222	4	j.	j.	PROPN
admet-2582	222	5	jiang	jiang	PROPN
admet-2582	222	6	,	,	PUNCT
admet-2582	222	7	l.	l.	PROPN
admet-2582	222	8	dong	dong	PROPN
admet-2582	222	9	,	,	PUNCT
admet-2582	222	10	l.	l.	PROPN
admet-2582	222	11	wang	wang	PROPN
admet-2582	222	12	,	,	PUNCT
admet-2582	222	13	l.	l.	PROPN
admet-2582	222	14	wang	wang	PROPN
admet-2582	222	15	,	,	PUNCT
admet-2582	222	16	j.	j.	PROPN
admet-2582	222	17	zhang	zhang	PROPN
admet-2582	222	18	,	,	PUNCT
admet-2582	222	19	f.	f.	PROPN
admet-2582	222	20	chen	chen	PROPN
admet-2582	222	21	,	,	PUNCT
admet-2582	222	22	x.	x.	PROPN
admet-2582	222	23	zhang	zhang	PROPN
admet-2582	222	24	,	,	PUNCT
admet-2582	222	25	m.	m.	PROPN
admet-2582	222	26	huang	huang	PROPN
admet-2582	222	27	,	,	PUNCT
admet-2582	222	28	s.	s.	PROPN
admet-2582	222	29	li	li	PROPN
admet-2582	222	30	,	,	PUNCT
admet-2582	222	31	w.	w.	PROPN
admet-2582	222	32	ma	ma	PROPN
admet-2582	222	33	,	,	PUNCT
admet-2582	222	34	q.	q.	PROPN
admet-2582	222	35	xu	xu	PROPN
admet-2582	222	36	,	,	PUNCT
admet-2582	222	37	c.	c.	PROPN
admet-2582	222	38	huang	huang	PROPN
admet-2582	222	39	,	,	PUNCT
admet-2582	222	40	j.	j.	PROPN
admet-2582	222	41	fang	fang	PROPN
admet-2582	222	42	,	,	PUNCT
admet-2582	222	43	c.	c.	PROPN
admet-2582	222	44	wang	wang	PROPN
admet-2582	222	45	.	.	PUNCT
admet-2582	223	1	her2	her2	PROPN
admet-2582	223	2	-	-	PUNCT
admet-2582	223	3	targeted	target	VERB
admet-2582	223	4	antibody	antibody	NOUN
admet-2582	223	5	drug	drug	NOUN
admet-2582	223	6	conjugates	conjugate	NOUN
admet-2582	223	7	for	for	ADP
admet-2582	223	8	ovarian	ovarian	ADJ
admet-2582	223	9	cancer	cancer	NOUN
admet-2582	223	10	therapy	therapy	NOUN
admet-2582	223	11	.	.	PUNCT
admet-2582	224	1	european	european	PROPN
admet-2582	224	2	journal	journal	PROPN
admet-2582	224	3	of	of	ADP
admet-2582	224	4	pharmaceutical	pharmaceutical	PROPN
admet-2582	224	5	sciences	science	NOUN
admet-2582	224	6	93	93	NUM
admet-2582	224	7	(	(	PUNCT
admet-2582	224	8	2016	2016	NUM
admet-2582	224	9	)	)	PUNCT
admet-2582	224	10	274	274	NUM
admet-2582	224	11	-	-	SYM
admet-2582	224	12	286	286	NUM
admet-2582	224	13	.	.	PUNCT
admet-2582	225	1	https://doi.org/10.1016/j.ejps.2016.08.015	https://doi.org/10.1016/j.ejps.2016.08.015	NOUN
admet-2582	225	2	[	[	X
admet-2582	225	3	4	4	NUM
admet-2582	225	4	]	]	PUNCT
admet-2582	225	5	x.	x.	NOUN
admet-2582	225	6	sheng	sheng	PROPN
admet-2582	225	7	,	,	PUNCT
admet-2582	225	8	x.	x.	PROPN
admet-2582	225	9	yan	yan	PROPN
admet-2582	225	10	,	,	PUNCT
admet-2582	225	11	l.	l.	PROPN
admet-2582	225	12	wang	wang	PROPN
admet-2582	225	13	,	,	PUNCT
admet-2582	225	14	y.	y.	PROPN
admet-2582	225	15	shi	shi	PROPN
admet-2582	225	16	,	,	PUNCT
admet-2582	225	17	x.	x.	PROPN
admet-2582	225	18	yao	yao	PROPN
admet-2582	225	19	,	,	PUNCT
admet-2582	225	20	h.	h.	PROPN
admet-2582	225	21	luo	luo	PROPN
admet-2582	225	22	,	,	PUNCT
admet-2582	225	23	b.	b.	PROPN
admet-2582	225	24	shi	shi	PROPN
admet-2582	225	25	,	,	PUNCT
admet-2582	225	26	j.	j.	PROPN
admet-2582	225	27	liu	liu	PROPN
admet-2582	225	28	,	,	PUNCT
admet-2582	225	29	z.	z.	PROPN
admet-2582	226	1	he	he	PRON
admet-2582	226	2	,	,	PUNCT
admet-2582	226	3	g.	g.	PROPN
admet-2582	226	4	yu	yu	PROPN
admet-2582	226	5	,	,	PUNCT
admet-2582	226	6	j.	j.	PROPN
admet-2582	226	7	ying	ying	PROPN
admet-2582	226	8	,	,	PUNCT
admet-2582	226	9	w.	w.	PROPN
admet-2582	226	10	han	han	PROPN
admet-2582	226	11	,	,	PUNCT
admet-2582	226	12	c.	c.	PROPN
admet-2582	226	13	hu	hu	PROPN
admet-2582	226	14	,	,	PUNCT
admet-2582	226	15	y.	y.	PROPN
admet-2582	226	16	ling	ling	PROPN
admet-2582	226	17	,	,	PUNCT
admet-2582	226	18	z.	z.	PROPN
admet-2582	226	19	chi	chi	PROPN
admet-2582	226	20	,	,	PUNCT
admet-2582	226	21	c.	c.	PROPN
admet-2582	226	22	cui	cui	PROPN
admet-2582	226	23	,	,	PUNCT
admet-2582	226	24	l.	l.	PROPN
admet-2582	226	25	si	si	PROPN
admet-2582	226	26	,	,	PUNCT
admet-2582	226	27	j.	j.	PROPN
admet-2582	226	28	fang	fang	PROPN
admet-2582	226	29	,	,	PUNCT
admet-2582	226	30	a.	a.	NOUN
admet-2582	226	31	zhou	zhou	PROPN
admet-2582	226	32	,	,	PUNCT
admet-2582	226	33	j.	j.	PROPN
admet-2582	226	34	guo	guo	PROPN
admet-2582	226	35	.	.	PUNCT
admet-2582	227	1	open	open	ADJ
admet-2582	227	2	-	-	PUNCT
admet-2582	227	3	label	label	NOUN
admet-2582	227	4	,	,	PUNCT
admet-2582	227	5	multicenter	multicenter	NOUN
admet-2582	227	6	,	,	PUNCT
admet-2582	227	7	phase	phase	NOUN
admet-2582	227	8	ii	ii	PROPN
admet-2582	227	9	study	study	NOUN
admet-2582	227	10	of	of	ADP
admet-2582	227	11	rc48	rc48	PROPN
admet-2582	227	12	-	-	PUNCT
admet-2582	227	13	adc	adc	PROPN
admet-2582	227	14	,	,	PUNCT
admet-2582	227	15	a	a	DET
admet-2582	227	16	her2	her2	NOUN
admet-2582	227	17	-	-	PUNCT
admet-2582	227	18	targeting	target	VERB
admet-2582	227	19	antibody	antibody	NOUN
admet-2582	227	20	-	-	PUNCT
admet-2582	227	21	drug	drug	NOUN
admet-2582	227	22	conjugate	conjugate	NOUN
admet-2582	227	23	,	,	PUNCT
admet-2582	227	24	in	in	ADP
admet-2582	227	25	patients	patient	NOUN
admet-2582	227	26	with	with	ADP
admet-2582	227	27	locally	locally	ADV
admet-2582	227	28	advanced	advanced	ADJ
admet-2582	227	29	or	or	CCONJ
admet-2582	227	30	metastatic	metastatic	ADJ
admet-2582	227	31	urothelial	urothelial	ADJ
admet-2582	227	32	carcinoma	carcinoma	NOUN
admet-2582	227	33	.	.	PUNCT
admet-2582	228	1	clinical	clinical	ADJ
admet-2582	228	2	cancer	cancer	NOUN
admet-2582	228	3	research	research	NOUN
admet-2582	228	4	27	27	NUM
admet-2582	228	5	(	(	PUNCT
admet-2582	228	6	2021	2021	NUM
admet-2582	228	7	)	)	PUNCT
admet-2582	228	8	43	43	NUM
admet-2582	228	9	-	-	SYM
admet-2582	228	10	51	51	NUM
admet-2582	228	11	.	.	PUNCT
admet-2582	229	1	https://doi.org/10.1158/10780432.ccr-20-2488	https://doi.org/10.1158/10780432.ccr-20-2488	NOUN
admet-2582	230	1	[	[	X
admet-2582	230	2	5	5	NUM
admet-2582	230	3	]	]	PUNCT
admet-2582	230	4	z.	z.	PROPN
admet-2582	230	5	peng	peng	PROPN
admet-2582	230	6	,	,	PUNCT
admet-2582	230	7	t.	t.	PROPN
admet-2582	230	8	liu	liu	PROPN
admet-2582	230	9	,	,	PUNCT
admet-2582	230	10	j.	j.	PROPN
admet-2582	230	11	wei	wei	PROPN
admet-2582	230	12	,	,	PUNCT
admet-2582	230	13	a.	a.	PROPN
admet-2582	230	14	wang	wang	PROPN
admet-2582	230	15	,	,	PUNCT
admet-2582	230	16	y.	y.	PROPN
admet-2582	230	17	he	he	PRON
admet-2582	230	18	,	,	PUNCT
admet-2582	230	19	l.	l.	PROPN
admet-2582	230	20	yang	yang	PROPN
admet-2582	230	21	,	,	PUNCT
admet-2582	230	22	x.	x.	PROPN
admet-2582	230	23	zhang	zhang	PROPN
admet-2582	230	24	,	,	PUNCT
admet-2582	230	25	n.	n.	PROPN
admet-2582	230	26	fan	fan	PROPN
admet-2582	230	27	,	,	PUNCT
admet-2582	230	28	s.	s.	PROPN
admet-2582	230	29	luo	luo	PROPN
admet-2582	230	30	,	,	PUNCT
admet-2582	230	31	z.	z.	PROPN
admet-2582	230	32	li	li	PROPN
admet-2582	230	33	,	,	PUNCT
admet-2582	230	34	k.	k.	PROPN
admet-2582	230	35	gu	gu	PROPN
admet-2582	230	36	,	,	PUNCT
admet-2582	230	37	j.	j.	PROPN
admet-2582	230	38	lu	lu	PROPN
admet-2582	230	39	,	,	PUNCT
admet-2582	230	40	j.	j.	PROPN
admet-2582	230	41	xu	xu	PROPN
admet-2582	230	42	,	,	PUNCT
admet-2582	230	43	q.	q.	PROPN
admet-2582	230	44	fan	fan	PROPN
admet-2582	230	45	,	,	PUNCT
admet-2582	230	46	r.	r.	PROPN
admet-2582	230	47	xu	xu	PROPN
admet-2582	230	48	,	,	PUNCT
admet-2582	230	49	l.	l.	PROPN
admet-2582	230	50	zhang	zhang	PROPN
admet-2582	230	51	,	,	PUNCT
admet-2582	230	52	e.	e.	PROPN
admet-2582	230	53	li	li	PROPN
admet-2582	230	54	,	,	PUNCT
admet-2582	230	55	y.	y.	PROPN
admet-2582	230	56	sun	sun	PROPN
admet-2582	230	57	,	,	PUNCT
admet-2582	230	58	g.	g.	PROPN
admet-2582	230	59	yu	yu	PROPN
admet-2582	230	60	,	,	PUNCT
admet-2582	230	61	c.	c.	PROPN
admet-2582	230	62	bai	bai	PROPN
admet-2582	230	63	,	,	PUNCT
admet-2582	230	64	y.	y.	PROPN
admet-2582	230	65	liu	liu	PROPN
admet-2582	230	66	,	,	PUNCT
admet-2582	230	67	j.	j.	PROPN
admet-2582	230	68	zeng	zeng	PROPN
admet-2582	230	69	,	,	PUNCT
admet-2582	230	70	j.	j.	PROPN
admet-2582	230	71	ying	ying	PROPN
admet-2582	230	72	,	,	PUNCT
admet-2582	230	73	x.	x.	PROPN
admet-2582	230	74	liang	liang	PROPN
admet-2582	230	75	,	,	PUNCT
admet-2582	230	76	n.	n.	PROPN
admet-2582	230	77	xu	xu	PROPN
admet-2582	230	78	,	,	PUNCT
admet-2582	230	79	c.	c.	PROPN
admet-2582	230	80	gao	gao	PROPN
admet-2582	230	81	,	,	PUNCT
admet-2582	230	82	y.	y.	PROPN
admet-2582	230	83	shu	shu	PROPN
admet-2582	230	84	,	,	PUNCT
admet-2582	230	85	d.	d.	PROPN
admet-2582	230	86	ma	ma	PROPN
admet-2582	230	87	,	,	PUNCT
admet-2582	230	88	g.	g.	PROPN
admet-2582	230	89	dai	dai	PROPN
admet-2582	230	90	,	,	PUNCT
admet-2582	230	91	s.	s.	PROPN
admet-2582	230	92	li	li	PROPN
admet-2582	230	93	,	,	PUNCT
admet-2582	230	94	t.	t.	PROPN
admet-2582	230	95	deng	deng	PROPN
admet-2582	230	96	,	,	PUNCT
admet-2582	230	97	y.	y.	PROPN
admet-2582	230	98	cui	cui	PROPN
admet-2582	230	99	,	,	PUNCT
admet-2582	230	100	j.	j.	PROPN
admet-2582	230	101	fang	fang	PROPN
admet-2582	230	102	,	,	PUNCT
admet-2582	230	103	y.	y.	PROPN
admet-2582	230	104	ba	ba	PROPN
admet-2582	230	105	,	,	PUNCT
admet-2582	230	106	l.	l.	PROPN
admet-2582	230	107	shen	shen	PROPN
admet-2582	230	108	.	.	PUNCT
admet-2582	231	1	efficacy	efficacy	NOUN
admet-2582	231	2	and	and	CCONJ
admet-2582	231	3	safety	safety	NOUN
admet-2582	231	4	of	of	ADP
admet-2582	231	5	a	a	DET
admet-2582	231	6	novel	novel	ADJ
admet-2582	231	7	anti	anti	ADJ
admet-2582	231	8	-	-	ADJ
admet-2582	231	9	her2	her2	ADJ
admet-2582	231	10	therapeutic	therapeutic	ADJ
admet-2582	231	11	antibody	antibody	NOUN
admet-2582	231	12	rc48	rc48	PROPN
admet-2582	231	13	in	in	ADP
admet-2582	231	14	patients	patient	NOUN
admet-2582	231	15	with	with	ADP
admet-2582	231	16	her2	her2	PROPN
admet-2582	231	17	-	-	PUNCT
admet-2582	231	18	overexpressing	overexpresse	VERB
admet-2582	231	19	,	,	PUNCT
admet-2582	231	20	locally	locally	ADV
admet-2582	231	21	advanced	advanced	ADJ
admet-2582	231	22	or	or	CCONJ
admet-2582	231	23	metastatic	metastatic	ADJ
admet-2582	231	24	gastric	gastric	NOUN
admet-2582	231	25	or	or	CCONJ
admet-2582	231	26	gastroesophageal	gastroesophageal	VERB
admet-2582	231	27	junction	junction	NOUN
admet-2582	231	28	cancer	cancer	NOUN
admet-2582	231	29	:	:	PUNCT
admet-2582	231	30	a	a	DET
admet-2582	231	31	single	single	ADJ
admet-2582	231	32	-	-	PUNCT
admet-2582	231	33	arm	arm	NOUN
admet-2582	231	34	phase	phase	NOUN
admet-2582	231	35	ii	ii	PROPN
admet-2582	231	36	study	study	NOUN
admet-2582	231	37	.	.	PUNCT
admet-2582	232	1	cancer	cancer	NOUN
admet-2582	232	2	communications	communication	NOUN
admet-2582	232	3	41	41	NUM
admet-2582	232	4	(	(	PUNCT
admet-2582	232	5	2021	2021	NUM
admet-2582	232	6	)	)	PUNCT
admet-2582	232	7	1173	1173	NUM
admet-2582	232	8	-	-	SYM
admet-2582	232	9	1182	1182	NUM
admet-2582	232	10	.	.	PUNCT
admet-2582	233	1	https://doi.org/10.1002/cac2.12214	https://doi.org/10.1002/cac2.12214	NOUN
admet-2582	233	2	[	[	X
admet-2582	233	3	6	6	NUM
admet-2582	233	4	]	]	X
admet-2582	233	5	y.	y.	PROPN
admet-2582	233	6	xu	xu	PROPN
admet-2582	233	7	,	,	PUNCT
admet-2582	233	8	y.	y.	PROPN
admet-2582	233	9	wang	wang	PROPN
admet-2582	233	10	,	,	PUNCT
admet-2582	233	11	j.	j.	PROPN
admet-2582	233	12	gong	gong	PROPN
admet-2582	233	13	,	,	PUNCT
admet-2582	233	14	x.	x.	PROPN
admet-2582	233	15	zhang	zhang	PROPN
admet-2582	233	16	,	,	PUNCT
admet-2582	233	17	z.	z.	PROPN
admet-2582	233	18	peng	peng	PROPN
admet-2582	233	19	,	,	PUNCT
admet-2582	233	20	x.	x.	PROPN
admet-2582	233	21	sheng	sheng	PROPN
admet-2582	233	22	,	,	PUNCT
admet-2582	233	23	c.	c.	PROPN
admet-2582	233	24	mao	mao	PROPN
admet-2582	233	25	,	,	PUNCT
admet-2582	233	26	q.	q.	PROPN
admet-2582	233	27	fan	fan	PROPN
admet-2582	233	28	,	,	PUNCT
admet-2582	233	29	y.	y.	PROPN
admet-2582	233	30	bai	bai	PROPN
admet-2582	233	31	,	,	PUNCT
admet-2582	233	32	y.	y.	PROPN
admet-2582	233	33	ba	ba	PROPN
admet-2582	233	34	,	,	PUNCT
admet-2582	233	35	d.	d.	PROPN
admet-2582	233	36	jiang	jiang	PROPN
admet-2582	233	37	,	,	PUNCT
admet-2582	233	38	f.	f.	PROPN
admet-2582	233	39	yang	yang	PROPN
admet-2582	233	40	,	,	PUNCT
admet-2582	233	41	c.	c.	PROPN
admet-2582	233	42	qi	qi	PROPN
admet-2582	233	43	,	,	PUNCT
admet-2582	233	44	j.	j.	PROPN
admet-2582	233	45	li	li	PROPN
admet-2582	233	46	,	,	PUNCT
admet-2582	233	47	x.	x.	PROPN
admet-2582	233	48	wang	wang	PROPN
admet-2582	233	49	,	,	PUNCT
admet-2582	233	50	j.	j.	PROPN
admet-2582	233	51	zhou	zhou	PROPN
admet-2582	233	52	,	,	PUNCT
admet-2582	233	53	m.	m.	NOUN
admet-2582	233	54	lu	lu	PROPN
admet-2582	233	55	,	,	PUNCT
admet-2582	233	56	y.	y.	PROPN
admet-2582	233	57	cao	cao	PROPN
admet-2582	233	58	,	,	PUNCT
admet-2582	233	59	j.	j.	PROPN
admet-2582	233	60	yuan	yuan	PROPN
admet-2582	233	61	,	,	PUNCT
admet-2582	233	62	d.	d.	PROPN
admet-2582	233	63	liu	liu	PROPN
admet-2582	233	64	,	,	PUNCT
admet-2582	233	65	z.	z.	PROPN
admet-2582	233	66	wang	wang	PROPN
admet-2582	233	67	,	,	PUNCT
admet-2582	233	68	j.	j.	PROPN
admet-2582	233	69	fang	fang	PROPN
admet-2582	233	70	,	,	PUNCT
admet-2582	233	71	l.	l.	PROPN
admet-2582	233	72	shen	shen	PROPN
admet-2582	233	73	.	.	PUNCT
admet-2582	234	1	phase	phase	NOUN
admet-2582	234	2	i	i	PRON
admet-2582	234	3	study	study	VERB
admet-2582	234	4	of	of	ADP
admet-2582	234	5	the	the	DET
admet-2582	234	6	recombinant	recombinant	ADJ
admet-2582	234	7	humanized	humanize	VERB
admet-2582	234	8	anti	anti	ADJ
admet-2582	234	9	-	-	ADJ
admet-2582	234	10	her2	her2	ADJ
admet-2582	234	11	monoclonal	monoclonal	NOUN
admet-2582	234	12	antibody	antibody	NOUN
admet-2582	234	13	-	-	PUNCT
admet-2582	234	14	mmae	mmae	NOUN
admet-2582	234	15	conjugate	conjugate	ADJ
admet-2582	234	16	rc48	rc48	PROPN
admet-2582	234	17	-	-	PUNCT
admet-2582	234	18	adc	adc	PROPN
admet-2582	234	19	in	in	ADP
admet-2582	234	20	patients	patient	NOUN
admet-2582	234	21	with	with	ADP
admet-2582	234	22	her2	her2	PROPN
admet-2582	234	23	-	-	PUNCT
admet-2582	234	24	positive	positive	ADJ
admet-2582	234	25	advanced	advanced	ADJ
admet-2582	234	26	solid	solid	ADJ
admet-2582	234	27	tumors	tumor	NOUN
admet-2582	234	28	.	.	PUNCT
admet-2582	235	1	gastric	gastric	ADJ
admet-2582	235	2	cancer	cancer	NOUN
admet-2582	235	3	24	24	NUM
admet-2582	235	4	(	(	PUNCT
admet-2582	235	5	2021	2021	NUM
admet-2582	235	6	)	)	PUNCT
admet-2582	235	7	913	913	NUM
admet-2582	235	8	-	-	SYM
admet-2582	235	9	925	925	NUM
admet-2582	235	10	.	.	PUNCT
admet-2582	235	11	https://doi.org/10.1007/s10120-021-01168-7	https://doi.org/10.1007/s10120-021-01168-7	PUNCT
admet-2582	236	1	[	[	X
admet-2582	236	2	7	7	X
admet-2582	236	3	]	]	X
admet-2582	236	4	j.	j.	PROPN
admet-2582	236	5	kalmuk	kalmuk	PROPN
admet-2582	236	6	,	,	PUNCT
admet-2582	236	7	d.	d.	PROPN
admet-2582	236	8	rinder	rinder	PROPN
admet-2582	236	9	,	,	PUNCT
admet-2582	236	10	c.	c.	PROPN
admet-2582	236	11	heltzel	heltzel	PROPN
admet-2582	236	12	,	,	PUNCT
admet-2582	236	13	a.c	a.c	PROPN
admet-2582	236	14	.	.	PROPN
admet-2582	236	15	lockhart	lockhart	PROPN
admet-2582	236	16	.	.	PUNCT
admet-2582	237	1	an	an	DET
admet-2582	237	2	overview	overview	NOUN
admet-2582	237	3	of	of	ADP
admet-2582	237	4	the	the	DET
admet-2582	237	5	preclinical	preclinical	ADJ
admet-2582	237	6	discovery	discovery	NOUN
admet-2582	237	7	and	and	CCONJ
admet-2582	237	8	development	development	NOUN
admet-2582	237	9	of	of	ADP
admet-2582	237	10	trastuzumab	trastuzumab	NOUN
admet-2582	237	11	deruxtecan	deruxtecan	ADJ
admet-2582	237	12	:	:	PUNCT
admet-2582	237	13	a	a	DET
admet-2582	237	14	novel	novel	ADJ
admet-2582	237	15	gastric	gastric	ADJ
admet-2582	237	16	cancer	cancer	NOUN
admet-2582	237	17	therapeutic	therapeutic	ADJ
admet-2582	237	18	.	.	PUNCT
admet-2582	238	1	expert	expert	ADJ
admet-2582	238	2	opinion	opinion	NOUN
admet-2582	238	3	on	on	ADP
admet-2582	238	4	drug	drug	NOUN
admet-2582	238	5	discovery	discovery	NOUN
admet-2582	238	6	17	17	NUM
admet-2582	238	7	(	(	PUNCT
admet-2582	238	8	2022	2022	NUM
admet-2582	238	9	)	)	PUNCT
admet-2582	238	10	427	427	NUM
admet-2582	238	11	-	-	SYM
admet-2582	238	12	436	436	NUM
admet-2582	238	13	.	.	PUNCT
admet-2582	238	14	https://doi.org/10.1080/17460441.2022.2050692	https://doi.org/10.1080/17460441.2022.2050692	PROPN
admet-2582	239	1	[	[	X
admet-2582	239	2	8	8	NUM
admet-2582	239	3	]	]	X
admet-2582	239	4	c.	c.	PROPN
admet-2582	239	5	li	li	PROPN
admet-2582	239	6	,	,	PUNCT
admet-2582	239	7	c.	c.	PROPN
admet-2582	239	8	zhang	zhang	PROPN
admet-2582	239	9	,	,	PUNCT
admet-2582	239	10	r.	r.	PROPN
admet-2582	239	11	deng	deng	PROPN
admet-2582	239	12	,	,	PUNCT
admet-2582	239	13	d.	d.	PROPN
admet-2582	239	14	leipold	leipold	PROPN
admet-2582	239	15	,	,	PUNCT
admet-2582	239	16	d.	d.	PROPN
admet-2582	239	17	li	li	PROPN
admet-2582	239	18	,	,	PUNCT
admet-2582	239	19	b.	b.	PROPN
admet-2582	239	20	latifi	latifi	PROPN
admet-2582	239	21	,	,	PUNCT
admet-2582	239	22	y.	y.	PROPN
admet-2582	239	23	gao	gao	PROPN
admet-2582	239	24	,	,	PUNCT
admet-2582	239	25	c.	c.	PROPN
admet-2582	239	26	zhang	zhang	PROPN
admet-2582	239	27	,	,	PUNCT
admet-2582	239	28	z.	z.	PROPN
admet-2582	239	29	li	li	PROPN
admet-2582	239	30	,	,	PUNCT
admet-2582	239	31	d.	d.	PROPN
admet-2582	239	32	miles	miles	PROPN
admet-2582	239	33	,	,	PUNCT
admet-2582	239	34	s.c	s.c	PROPN
admet-2582	239	35	.	.	PROPN
admet-2582	239	36	chen	chen	PROPN
admet-2582	239	37	,	,	PUNCT
admet-2582	239	38	d.	d.	PROPN
admet-2582	239	39	samineni	samineni	PROPN
admet-2582	239	40	,	,	PUNCT
admet-2582	239	41	b.	b.	PROPN
admet-2582	239	42	wang	wang	PROPN
admet-2582	239	43	,	,	PUNCT
admet-2582	239	44	p.	p.	PROPN
admet-2582	239	45	agarwal	agarwal	PROPN
admet-2582	239	46	,	,	PUNCT
admet-2582	239	47	d.	d.	PROPN
admet-2582	239	48	lu	lu	PROPN
admet-2582	239	49	,	,	PUNCT
admet-2582	239	50	s.	s.	PROPN
admet-2582	239	51	prabhu	prabhu	PROPN
admet-2582	239	52	,	,	PUNCT
admet-2582	239	53	s.	s.	PROPN
admet-2582	239	54	girish	girish	PROPN
admet-2582	239	55	,	,	PUNCT
admet-2582	239	56	a.v	a.v	PROPN
admet-2582	239	57	.	.	PROPN
admet-2582	239	58	kamath	kamath	PROPN
admet-2582	239	59	.	.	PUNCT
admet-2582	239	60	prediction	prediction	NOUN
admet-2582	239	61	of	of	ADP
admet-2582	239	62	human	human	ADJ
admet-2582	239	63	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	239	64	of	of	ADP
admet-2582	239	65	antibody	antibody	NOUN
admet-2582	239	66	-	-	PUNCT
admet-2582	239	67	drug	drug	NOUN
admet-2582	239	68	conjugates	conjugate	NOUN
admet-2582	239	69	from	from	ADP
admet-2582	239	70	nonclinical	nonclinical	ADJ
admet-2582	239	71	data	datum	NOUN
admet-2582	239	72	.	.	PUNCT
admet-2582	240	1	clinical	clinical	ADJ
admet-2582	240	2	and	and	CCONJ
admet-2582	240	3	translational	translational	ADJ
admet-2582	240	4	science	science	NOUN
admet-2582	240	5	12	12	NUM
admet-2582	240	6	(	(	PUNCT
admet-2582	240	7	2019	2019	NUM
admet-2582	240	8	)	)	PUNCT
admet-2582	240	9	534	534	NUM
admet-2582	240	10	-	-	SYM
admet-2582	240	11	544	544	NUM
admet-2582	240	12	.	.	PUNCT
admet-2582	241	1	https://doi.org/10.1111/cts.12649	https://doi.org/10.1111/cts.12649	NOUN
admet-2582	241	2	[	[	X
admet-2582	241	3	9	9	NUM
admet-2582	241	4	]	]	SYM
admet-2582	241	5	s.n	s.n	PROPN
admet-2582	241	6	.	.	PROPN
admet-2582	241	7	liu	liu	PROPN
admet-2582	241	8	,	,	PUNCT
admet-2582	241	9	c.	c.	PROPN
admet-2582	241	10	li	li	PROPN
admet-2582	241	11	.	.	PROPN
admet-2582	242	1	clinical	clinical	ADJ
admet-2582	242	2	pharmacology	pharmacology	NOUN
admet-2582	242	3	strategies	strategy	NOUN
admet-2582	242	4	in	in	ADP
admet-2582	242	5	supporting	support	VERB
admet-2582	242	6	drug	drug	NOUN
admet-2582	242	7	development	development	NOUN
admet-2582	242	8	and	and	CCONJ
admet-2582	242	9	approval	approval	NOUN
admet-2582	242	10	of	of	ADP
admet-2582	242	11	antibody	antibody	NOUN
admet-2582	242	12	-	-	PUNCT
admet-2582	242	13	drug	drug	NOUN
admet-2582	242	14	conjugates	conjugate	NOUN
admet-2582	242	15	in	in	ADP
admet-2582	242	16	oncology	oncology	NOUN
admet-2582	242	17	.	.	PUNCT
admet-2582	243	1	cancer	cancer	NOUN
admet-2582	243	2	chemotherapy	chemotherapy	NOUN
admet-2582	243	3	and	and	CCONJ
admet-2582	243	4	pharmacology	pharmacology	NOUN
admet-2582	243	5	87	87	NUM
admet-2582	243	6	(	(	PUNCT
admet-2582	243	7	2021	2021	NUM
admet-2582	243	8	)	)	PUNCT
admet-2582	243	9	743	743	NUM
admet-2582	243	10	-	-	SYM
admet-2582	243	11	765	765	NUM
admet-2582	243	12	.	.	PUNCT
admet-2582	244	1	https://doi.org/10.1007/s00280-021-04250-0	https://doi.org/10.1007/s00280-021-04250-0	NUM
admet-2582	244	2	https://doi.org/10.3390/molecules25204764	https://doi.org/10.3390/molecules25204764	NOUN
admet-2582	244	3	https://doi.org/10.1038/d41573-021-00054-2	https://doi.org/10.1038/d41573-021-00054-2	PROPN
admet-2582	245	1	https://doi.org/10.1016/j.ejps.2016.08.015	https://doi.org/10.1016/j.ejps.2016.08.015	NOUN
admet-2582	245	2	https://doi.org/10.1158/1078-0432.ccr-20-2488	https://doi.org/10.1158/1078-0432.ccr-20-2488	NUM
admet-2582	245	3	https://doi.org/10.1158/1078-0432.ccr-20-2488	https://doi.org/10.1158/1078-0432.ccr-20-2488	NUM
admet-2582	245	4	https://doi.org/10.1002/cac2.12214	https://doi.org/10.1002/cac2.12214	NOUN
admet-2582	245	5	https://doi.org/10.1007/s10120-021-01168-7	https://doi.org/10.1007/s10120-021-01168-7	NUM
admet-2582	245	6	https://doi.org/10.1080/17460441.2022.2050692	https://doi.org/10.1080/17460441.2022.2050692	PROPN
admet-2582	245	7	https://doi.org/10.1111/cts.12649	https://doi.org/10.1111/cts.12649	PROPN
admet-2582	245	8	https://doi.org/10.1007/s00280-021-04250-0	https://doi.org/10.1007/s00280-021-04250-0	NUM
admet-2582	245	9	admet	admet	PROPN
admet-2582	245	10	&	&	CCONJ
admet-2582	245	11	dmpk	dmpk	PROPN
admet-2582	245	12	13(2	13(2	PROPN
admet-2582	245	13	)	)	PUNCT
admet-2582	245	14	(	(	PUNCT
admet-2582	245	15	2025	2025	NUM
admet-2582	245	16	)	)	PUNCT
admet-2582	245	17	2582	2582	NUM
admet-2582	245	18	disitamab	disitamab	VERB
admet-2582	245	19	vedotin	vedotin	ADJ
admet-2582	245	20	pharmacokinetics	pharmacokinetic	NOUN
admet-2582	245	21	,	,	PUNCT
admet-2582	245	22	distribution	distribution	NOUN
admet-2582	245	23	and	and	CCONJ
admet-2582	245	24	metabolism	metabolism	NOUN
admet-2582	245	25	doi	doi	NOUN
admet-2582	245	26	:	:	PUNCT
admet-2582	245	27	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	245	28	13	13	NUM
admet-2582	245	29	[	[	SYM
admet-2582	245	30	10	10	NUM
admet-2582	245	31	]	]	PUNCT
admet-2582	245	32	`	`	PUNCT
admet-2582	245	33	p.m.	p.m.	NOUN
admet-2582	245	34	drake	drake	PROPN
admet-2582	245	35	,	,	PUNCT
admet-2582	245	36	d.	d.	PROPN
admet-2582	245	37	rabuka	rabuka	PROPN
admet-2582	245	38	.	.	PUNCT
admet-2582	246	1	recent	recent	ADJ
admet-2582	246	2	developments	development	NOUN
admet-2582	246	3	in	in	ADP
admet-2582	246	4	adc	adc	PROPN
admet-2582	246	5	technology	technology	NOUN
admet-2582	246	6	:	:	PUNCT
admet-2582	246	7	preclinical	preclinical	ADJ
admet-2582	246	8	studies	study	NOUN
admet-2582	246	9	signal	signal	VERB
admet-2582	246	10	future	future	ADJ
admet-2582	246	11	clinical	clinical	ADJ
admet-2582	246	12	trends	trend	NOUN
admet-2582	246	13	.	.	PUNCT
admet-2582	247	1	biodrugs	biodrug	NOUN
admet-2582	247	2	31	31	NUM
admet-2582	247	3	(	(	PUNCT
admet-2582	247	4	2017	2017	NUM
admet-2582	247	5	)	)	PUNCT
admet-2582	247	6	521	521	NUM
admet-2582	247	7	-	-	SYM
admet-2582	247	8	531	531	NUM
admet-2582	247	9	.	.	PUNCT
admet-2582	248	1	https://doi.org/10.1007/s40259-017-0254-1	https://doi.org/10.1007/s40259-017-0254-1	NUM
admet-2582	249	1	[	[	X
admet-2582	249	2	11	11	NUM
admet-2582	249	3	]	]	X
admet-2582	249	4	a.v	a.v	PROPN
admet-2582	249	5	.	.	PROPN
admet-2582	249	6	kamath	kamath	PROPN
admet-2582	249	7	,	,	PUNCT
admet-2582	249	8	s.	s.	PROPN
admet-2582	249	9	iyer	iyer	PROPN
admet-2582	249	10	.	.	PUNCT
admet-2582	250	1	challenges	challenge	NOUN
admet-2582	250	2	and	and	CCONJ
admet-2582	250	3	advances	advance	NOUN
admet-2582	250	4	in	in	ADP
admet-2582	250	5	the	the	DET
admet-2582	250	6	assessment	assessment	NOUN
admet-2582	250	7	of	of	ADP
admet-2582	250	8	the	the	DET
admet-2582	250	9	disposition	disposition	NOUN
admet-2582	250	10	of	of	ADP
admet-2582	250	11	antibody	antibody	NOUN
admet-2582	250	12	-	-	PUNCT
admet-2582	250	13	drug	drug	NOUN
admet-2582	250	14	conjugates	conjugate	NOUN
admet-2582	250	15	.	.	PUNCT
admet-2582	251	1	biopharm	biopharm	NOUN
admet-2582	251	2	.	.	PUNCT
admet-2582	252	1	drug	drug	PROPN
admet-2582	252	2	dispos	dispos	PROPN
admet-2582	252	3	.	.	PUNCT
admet-2582	253	1	37	37	NUM
admet-2582	253	2	(	(	PUNCT
admet-2582	253	3	2016	2016	NUM
admet-2582	253	4	)	)	PUNCT
admet-2582	253	5	66	66	NUM
admet-2582	253	6	-	-	SYM
admet-2582	253	7	74	74	NUM
admet-2582	253	8	.	.	PUNCT
admet-2582	254	1	https://doi.org/10.1002/bdd.1957	https://doi.org/10.1002/bdd.1957	NOUN
admet-2582	254	2	[	[	X
admet-2582	254	3	12	12	NUM
admet-2582	254	4	]	]	X
admet-2582	254	5	j.	j.	PROPN
admet-2582	254	6	bolleddula	bolleddula	PROPN
admet-2582	254	7	,	,	PUNCT
admet-2582	254	8	k.	k.	PROPN
admet-2582	254	9	brady	brady	PROPN
admet-2582	254	10	,	,	PUNCT
admet-2582	254	11	g.	g.	PROPN
admet-2582	254	12	bruin	bruin	PROPN
admet-2582	254	13	,	,	PUNCT
admet-2582	254	14	a.	a.	PROPN
admet-2582	254	15	lee	lee	PROPN
admet-2582	254	16	,	,	PUNCT
admet-2582	254	17	j.a	j.a	PROPN
admet-2582	254	18	.	.	PROPN
admet-2582	254	19	martin	martin	PROPN
admet-2582	254	20	,	,	PUNCT
admet-2582	254	21	m.	m.	NOUN
admet-2582	254	22	walles	walles	PROPN
admet-2582	254	23	,	,	PUNCT
admet-2582	254	24	k.	k.	PROPN
admet-2582	254	25	xu	xu	PROPN
admet-2582	254	26	,	,	PUNCT
admet-2582	254	27	t.y	t.y	PROPN
admet-2582	254	28	.	.	PROPN
admet-2582	254	29	yang	yang	PROPN
admet-2582	254	30	,	,	PUNCT
admet-2582	254	31	x.	x.	PROPN
admet-2582	254	32	zhu	zhu	PROPN
admet-2582	254	33	,	,	PUNCT
admet-2582	254	34	h.	h.	PROPN
admet-2582	254	35	yu	yu	PROPN
admet-2582	254	36	.	.	PUNCT
admet-2582	255	1	absorption	absorption	NOUN
admet-2582	255	2	,	,	PUNCT
admet-2582	255	3	distribution	distribution	NOUN
admet-2582	255	4	,	,	PUNCT
admet-2582	255	5	metabolism	metabolism	NOUN
admet-2582	255	6	,	,	PUNCT
admet-2582	255	7	and	and	CCONJ
admet-2582	255	8	excretion	excretion	NOUN
admet-2582	255	9	of	of	ADP
admet-2582	255	10	therapeutic	therapeutic	ADJ
admet-2582	255	11	proteins	protein	NOUN
admet-2582	255	12	:	:	PUNCT
admet-2582	255	13	current	current	ADJ
admet-2582	255	14	industry	industry	NOUN
admet-2582	255	15	practices	practice	NOUN
admet-2582	255	16	and	and	CCONJ
admet-2582	255	17	future	future	ADJ
admet-2582	255	18	perspectives	perspective	NOUN
admet-2582	255	19	.	.	PUNCT
admet-2582	256	1	drug	drug	NOUN
admet-2582	256	2	metabolism	metabolism	NOUN
admet-2582	256	3	and	and	CCONJ
admet-2582	256	4	disposition	disposition	NOUN
admet-2582	256	5	50	50	NUM
admet-2582	256	6	(	(	PUNCT
admet-2582	256	7	2022	2022	NUM
admet-2582	256	8	)	)	PUNCT
admet-2582	256	9	837	837	NUM
admet-2582	256	10	-	-	SYM
admet-2582	256	11	845	845	NUM
admet-2582	256	12	.	.	PUNCT
admet-2582	257	1	https://doi.org/10.1124/dmd.121.000461	https://doi.org/10.1124/dmd.121.000461	PROPN
admet-2582	257	2	[	[	X
admet-2582	257	3	13	13	NUM
admet-2582	257	4	]	]	PUNCT
admet-2582	257	5	the	the	DET
admet-2582	257	6	u.s	u.s	PROPN
admet-2582	257	7	.	.	PROPN
admet-2582	257	8	food	food	PROPN
admet-2582	257	9	and	and	CCONJ
admet-2582	257	10	drug	drug	NOUN
admet-2582	257	11	administration	administration	NOUN
admet-2582	257	12	.	.	PUNCT
admet-2582	258	1	https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/125388orig1s000pharmr.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/125388orig1s000pharmr.pdf	PUNCT
admet-2582	259	1	[	[	X
admet-2582	259	2	14	14	NUM
admet-2582	259	3	]	]	X
admet-2582	259	4	v.	v.	PROPN
admet-2582	259	5	yip	yip	PROPN
admet-2582	259	6	,	,	PUNCT
admet-2582	259	7	m.v	m.v	PROPN
admet-2582	259	8	.	.	PROPN
admet-2582	259	9	lee	lee	PROPN
admet-2582	259	10	,	,	PUNCT
admet-2582	259	11	o.m	o.m	PROPN
admet-2582	259	12	.	.	PROPN
admet-2582	259	13	saad	saad	PROPN
admet-2582	259	14	,	,	PUNCT
admet-2582	259	15	s.	s.	PROPN
admet-2582	259	16	ma	ma	PROPN
admet-2582	259	17	,	,	PUNCT
admet-2582	259	18	s.c	s.c	PROPN
admet-2582	259	19	.	.	PROPN
admet-2582	259	20	khojasteh	khojasteh	PROPN
admet-2582	259	21	,	,	PUNCT
admet-2582	259	22	b.q	b.q	PROPN
admet-2582	259	23	.	.	PROPN
admet-2582	259	24	shen	shen	PROPN
admet-2582	259	25	.	.	PUNCT
admet-2582	260	1	preclinical	preclinical	ADJ
admet-2582	260	2	characterization	characterization	NOUN
admet-2582	260	3	of	of	ADP
admet-2582	260	4	the	the	DET
admet-2582	260	5	distribution	distribution	NOUN
admet-2582	260	6	,	,	PUNCT
admet-2582	260	7	catabolism	catabolism	NOUN
admet-2582	260	8	,	,	PUNCT
admet-2582	260	9	and	and	CCONJ
admet-2582	260	10	elimination	elimination	NOUN
admet-2582	260	11	of	of	ADP
admet-2582	260	12	a	a	DET
admet-2582	260	13	polatuzumab	polatuzumab	NOUN
admet-2582	260	14	vedotin	vedotin	NOUN
admet-2582	260	15	-	-	PUNCT
admet-2582	260	16	piiq	piiq	NOUN
admet-2582	260	17	(	(	PUNCT
admet-2582	260	18	polivy	polivy	NOUN
admet-2582	260	19	®	®	NOUN
admet-2582	260	20	)	)	PUNCT
admet-2582	260	21	antibody	antibody	NOUN
admet-2582	260	22	-	-	PUNCT
admet-2582	260	23	drug	drug	NOUN
admet-2582	260	24	conjugate	conjugate	NOUN
admet-2582	260	25	in	in	ADP
admet-2582	260	26	sprague	sprague	NOUN
admet-2582	260	27	dawley	dawley	NOUN
admet-2582	260	28	rats	rat	NOUN
admet-2582	260	29	.	.	PUNCT
admet-2582	261	1	journal	journal	NOUN
admet-2582	261	2	of	of	ADP
admet-2582	261	3	clinical	clinical	ADJ
admet-2582	261	4	medicine	medicine	NOUN
admet-2582	261	5	10	10	NUM
admet-2582	261	6	(	(	PUNCT
admet-2582	261	7	2021	2021	NUM
admet-2582	261	8	)	)	PUNCT
admet-2582	261	9	1323	1323	NUM
admet-2582	261	10	.	.	PUNCT
admet-2582	262	1	https://doi.org/10.3390/jcm10061323	https://doi.org/10.3390/jcm10061323	PRON
admet-2582	263	1	[	[	X
admet-2582	263	2	15	15	NUM
admet-2582	263	3	]	]	X
admet-2582	263	4	t.h	t.h	PROPN
admet-2582	263	5	.	.	PROPN
admet-2582	263	6	han	han	PROPN
admet-2582	263	7	,	,	PUNCT
admet-2582	263	8	a.k	a.k	PROPN
admet-2582	263	9	.	.	PROPN
admet-2582	263	10	gopal	gopal	PROPN
admet-2582	263	11	,	,	PUNCT
admet-2582	263	12	r.	r.	PROPN
admet-2582	263	13	ramchandren	ramchandren	PROPN
admet-2582	263	14	,	,	PUNCT
admet-2582	263	15	a.	a.	NOUN
admet-2582	263	16	goy	goy	PROPN
admet-2582	263	17	,	,	PUNCT
admet-2582	263	18	r.	r.	PROPN
admet-2582	263	19	chen	chen	PROPN
admet-2582	263	20	,	,	PUNCT
admet-2582	263	21	j.v	j.v	PROPN
admet-2582	263	22	.	.	PROPN
admet-2582	263	23	matous	matous	PROPN
admet-2582	263	24	,	,	PUNCT
admet-2582	263	25	m.	m.	PROPN
admet-2582	263	26	cooper	cooper	PROPN
admet-2582	263	27	,	,	PUNCT
admet-2582	263	28	l.e	l.e	PROPN
admet-2582	263	29	.	.	PROPN
admet-2582	263	30	grove	grove	PROPN
admet-2582	263	31	,	,	PUNCT
admet-2582	263	32	s.c	s.c	PROPN
admet-2582	263	33	.	.	PROPN
admet-2582	263	34	alley	alley	PROPN
admet-2582	263	35	,	,	PUNCT
admet-2582	263	36	c.m	c.m	PROPN
admet-2582	263	37	.	.	PROPN
admet-2582	263	38	lynch	lynch	PROPN
admet-2582	263	39	,	,	PUNCT
admet-2582	263	40	o.a	o.a	PROPN
admet-2582	263	41	.	.	PROPN
admet-2582	263	42	o'connor	o'connor	PROPN
admet-2582	263	43	.	.	PUNCT
admet-2582	264	1	cyp3a	cyp3a	NOUN
admet-2582	264	2	-	-	PUNCT
admet-2582	264	3	mediated	mediate	VERB
admet-2582	264	4	drug	drug	NOUN
admet-2582	264	5	-	-	PUNCT
admet-2582	264	6	drug	drug	NOUN
admet-2582	264	7	interaction	interaction	NOUN
admet-2582	264	8	potential	potential	NOUN
admet-2582	264	9	and	and	CCONJ
admet-2582	264	10	excretion	excretion	NOUN
admet-2582	264	11	of	of	ADP
admet-2582	264	12	brentuximab	brentuximab	NOUN
admet-2582	264	13	vedotin	vedotin	NOUN
admet-2582	264	14	,	,	PUNCT
admet-2582	264	15	an	an	DET
admet-2582	264	16	antibody	antibody	NOUN
admet-2582	264	17	-	-	PUNCT
admet-2582	264	18	drug	drug	NOUN
admet-2582	264	19	conjugate	conjugate	NOUN
admet-2582	264	20	,	,	PUNCT
admet-2582	264	21	in	in	ADP
admet-2582	264	22	patients	patient	NOUN
admet-2582	264	23	with	with	ADP
admet-2582	264	24	cd30	cd30	PROPN
admet-2582	264	25	-	-	PUNCT
admet-2582	264	26	positive	positive	ADJ
admet-2582	264	27	hematologic	hematologic	NOUN
admet-2582	264	28	malignancies	malignancy	NOUN
admet-2582	264	29	.	.	PUNCT
admet-2582	265	1	the	the	DET
admet-2582	265	2	journal	journal	NOUN
admet-2582	265	3	of	of	ADP
admet-2582	265	4	clinical	clinical	ADJ
admet-2582	265	5	pharmacology	pharmacology	NOUN
admet-2582	265	6	53	53	NUM
admet-2582	265	7	(	(	PUNCT
admet-2582	265	8	2013	2013	NUM
admet-2582	265	9	)	)	PUNCT
admet-2582	265	10	866	866	NUM
admet-2582	265	11	-	-	SYM
admet-2582	265	12	877	877	NUM
admet-2582	265	13	.	.	PUNCT
admet-2582	266	1	https://doi.org/10.1002/jcph.116	https://doi.org/10.1002/jcph.116	PROPN
admet-2582	267	1	©	©	ADJ
admet-2582	267	2	2025	2025	NUM
admet-2582	267	3	by	by	ADP
admet-2582	267	4	the	the	DET
admet-2582	267	5	authors	author	NOUN
admet-2582	267	6	;	;	PUNCT
admet-2582	267	7	licensee	licensee	PROPN
admet-2582	267	8	iapc	iapc	PROPN
admet-2582	267	9	,	,	PUNCT
admet-2582	267	10	zagreb	zagreb	PROPN
admet-2582	267	11	,	,	PUNCT
admet-2582	267	12	croatia	croatia	PROPN
admet-2582	267	13	.	.	PUNCT
admet-2582	268	1	this	this	DET
admet-2582	268	2	article	article	NOUN
admet-2582	268	3	is	be	AUX
admet-2582	268	4	an	an	DET
admet-2582	268	5	open	open	ADJ
admet-2582	268	6	-	-	PUNCT
admet-2582	268	7	access	access	NOUN
admet-2582	268	8	article	article	NOUN
admet-2582	268	9	distributed	distribute	VERB
admet-2582	268	10	under	under	ADP
admet-2582	268	11	the	the	DET
admet-2582	268	12	terms	term	NOUN
admet-2582	268	13	and	and	CCONJ
admet-2582	268	14	conditions	condition	NOUN
admet-2582	268	15	of	of	ADP
admet-2582	268	16	the	the	DET
admet-2582	268	17	creative	creative	ADJ
admet-2582	268	18	commons	common	NOUN
admet-2582	268	19	attribution	attribution	NOUN
admet-2582	268	20	license	license	NOUN
admet-2582	268	21	(	(	PUNCT
admet-2582	268	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2582	268	23	)	)	PUNCT
admet-2582	268	24	https://doi.org/10.5599/admet.2582	https://doi.org/10.5599/admet.2582	NOUN
admet-2582	268	25	https://doi.org/10.1007/s40259-017-0254-1	https://doi.org/10.1007/s40259-017-0254-1	NUM
admet-2582	268	26	https://doi.org/10.1002/bdd.1957	https://doi.org/10.1002/bdd.1957	NOUN
admet-2582	268	27	https://doi.org/10.1124/dmd.121.000461	https://doi.org/10.1124/dmd.121.000461	PRON
admet-2582	268	28	https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/125388orig1s000pharmr.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/125388orig1s000pharmr.pdf	PROPN
admet-2582	268	29	https://doi.org/10.3390/jcm10061323	https://doi.org/10.3390/jcm10061323	PROPN
admet-2582	268	30	https://doi.org/10.1002/jcph.116	https://doi.org/10.1002/jcph.116	PROPN
admet-2582	268	31	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN